LOCUS 033_IIG_Bs27_014_SNP 3569742 bp DNA circular UNA 12-JAN-2021 DEFINITION Bacillus subtilis strain Delta6 (hybrid trycycler assembly). ACCESSION urn.local...1ed-cvskbtk VERSION urn.local...1ed-cvskbtk KEYWORDS . SOURCE ORGANISM . FEATURES Location/Qualifiers S_feature complement(3569632..658) /Source="Nicolas_S_feature" /locus_tag="new_299_1067_c" /HighExp="S4, LoTm, S3, C30, S5, S7, S6, T5.0H, S8, M9-stat" /AntisenseName="dnaA" /AntisenseCor="-0.57810076860528403" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S4" CDS 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2167836, 2846289, 12682299, 16120674, 1779750, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2167836, 2846289, 12682299, 16120674, 1779750, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosomal replication initiator informational ATPase" /protein_id="NP_387882.1" /db_xref="EnsemblGenomes-Gn:BSU00010" /db_xref="EnsemblGenomes-Tr:CAB11777" /db_xref="GOA:P05648" /db_xref="InterPro:IPR001957" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013159" /db_xref="InterPro:IPR013317" /db_xref="InterPro:IPR018312" /db_xref="InterPro:IPR020591" /db_xref="InterPro:IPR024633" /db_xref="InterPro:IPR027417" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG10065" /db_xref="UniProtKB/Swiss-Prot:P05648" /translation="MENILDLWNQALAQIEKKLSKPSFETWMKSTKAHSLQGDTLTIT APNEFARDWLESRYLHLIADTIYELTGEELSIKFVIPQNQDVEDFMPKPQVKKAVKED TSDFPQNMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL MHAIGHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQF LAGKEQTQEEFFHTFNTLHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPP DLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDIN ADLAAEALKDIIPSSKPKVITIKEIQRVVGQQFNIKLEDFKAKKRTKSVAFPRQIAMY LSREMTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLADDEQLQQHVKEIKEQLK*" /label="dnaA CDS" gene 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /label="dnaA gene" promotor_-10 complement(631..649) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657) /Source="Nicolas_upshifts" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(665..670) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1342..1529 /Source="Nicolas_S_feature" /locus_tag="new_1751_1938" /HighExp="G150, Heat, G180, G135, Paraq, Oxctl, dia0, LBGstat, S1, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S5" CDS 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2846289, 11395445, 12682299, 20453097, 23228104, 28878042" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846289, 11395445, 12682299, 20453097, 23228104, 28878042; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (beta subunit)" /protein_id="NP_387883.1" /db_xref="EnsemblGenomes-Gn:BSU00020" /db_xref="EnsemblGenomes-Tr:CAB11778" /db_xref="GOA:P05649" /db_xref="InterPro:IPR001001" /db_xref="InterPro:IPR022634" /db_xref="InterPro:IPR022635" /db_xref="InterPro:IPR022637" /db_xref="PDB:4TR6" /db_xref="SubtiList:BG10066" /db_xref="UniProtKB/Swiss-Prot:P05649" /translation="MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDGVSF TGSDSDISIESFIPKEEGDKEIVTIEQPGSIVLQARFFSEIVKKLPMATVEIEVQNQY LTIIRSGKAEFNLNGLDADEYPHLPQIEEHHAIQIPTDLLKNLIRQTVFAVSTSETRP ILTGVNWKVEQSELLCTATDSHRLALRKAKLDIPEDRSYNVVIPGKSLTELSKILDDN QELVDIVITETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAID RASLLAREGRNNVVKLSAKPAESIEISSNSPEIGKVVEAIVADQIEGEELNISFSPKY MLDALKVLEGAEIRVSFTGAMRPFLIRTPNDETIVQLILPVRTY*" /label="dnaN CDS" gene 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /label="dnaN gene" downshifts 2650 /Source="Nicolas_upshifts" /id="D1" /incds=0 /nref=29 /ntot=161 /MaxReadThrough="5.22584" /MaxDrop="4.17087" /score="21.887269" /energy="-14.2" /TU="U1" /idTUdmin="U1" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" promotor_-35 2731..2735 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2752..2771 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2760 /Source="Nicolas_upshifts" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24637032, 24939895" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24637032, 24939895; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA binding protein involved in ribosome maturation" /protein_id="NP_387884.1" /db_xref="EnsemblGenomes-Gn:BSU00030" /db_xref="EnsemblGenomes-Tr:CAB11779" /db_xref="GOA:P05650" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014330" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10067" /db_xref="UniProtKB/Swiss-Prot:P05650" /translation="MANPISIDTEMITLGQFLKLADVIQSGGMAKWFLSEHEVLVNDE PDNRRGRKLYVGDVVEIEGFGSFQVVN*" /label="rlbA CDS" gene 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /label="rlbA gene" CDS 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 16061691, 16385024, 22342069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 16061691, 16385024, 22342069; Product type f: factor" /codon_start=1 /transl_table=11 /product="RecA filament-DNA complex stabilisation, ssDNA and dsDNA binding, ATP binding" /protein_id="NP_387885.1" /db_xref="EnsemblGenomes-Gn:BSU00040" /db_xref="EnsemblGenomes-Tr:CAB11780" /db_xref="GOA:P05651" /db_xref="InterPro:IPR001238" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR018078" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10068" /db_xref="UniProtKB/Swiss-Prot:P05651" /translation="MYIQNLELTSYRNYDHAELQFENKVNVIIGENAQGKTNLMEAIY VLSMAKSHRTSNDKELIRWDKDYAKIEGRVMKQNGAIPMQLVISKKGKKGKVNHIEQQ KLSQYVGALNTIMFAPEDLNLVKGSPQVRRRFLDMEIGQVSPVYLHDLSLYQKILSQR NHFLKQLQTRKQTDRTMLDVLTDQLVEVAAKVVVKRLQFTAQLEKWAQPIHAGISRGL EELTLKYHTALDVSDPLDLSKIGDSYQEAFSKLREKEIERGVTLSGPHRDDVLFYVNG RDVQTYGSQGQQRTTALSLKLAEIDLIHEEIGEYPILLLDDVLSELDDYRQSHLLHTI QGRVQTFVTTTSVDGIDHETLRQAGMFRVQNGALVK*" /label="recF CDS" gene 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /label="recF gene" misc_feature 3226..3245 /Source="Nicolas_upshift_promotors" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3244 /Source="Nicolas_upshifts" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of extracellular matrix formation" /protein_id="NP_387886.2" /db_xref="EnsemblGenomes-Gn:BSU00050" /db_xref="EnsemblGenomes-Tr:CAB11781" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG10069" /db_xref="UniProtKB/Swiss-Prot:P37525" /translation="MYIHLGDDFVVSTRDIVGIFDFKANMSPIVEEFLKKQKHKVVPS VNGTPKSIVVTVQNIYYSPLSSSTLKKRAQFMFEIDS*" /label="remB CDS" gene 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /label="remB gene" CDS 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit B)" /protein_id="NP_387887.1" /db_xref="EnsemblGenomes-Gn:BSU00060" /db_xref="EnsemblGenomes-Tr:CAB11782" /db_xref="GOA:P05652" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR011557" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR034160" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10070" /db_xref="UniProtKB/Swiss-Prot:P05652" /translation="MEQQQNSYDENQIQVLEGLEAVRKRPGMYIGSTNSKGLHHLVWE IVDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHA GGKFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRGVPVTDLEIIG ETDHTGTTTHFVPDPEIFSETTEYDYDLLANRVRELAFLTKGVNITIEDKREGQERKN EYHYEGGIKSYVEYLNRSKEVVHEEPIYIEGEKDGITVEVALQYNDSYTSNIYSFTNN INTYEGGTHEAGFKTGLTRVINDYARKKGLIKENDPNLSGDDVREGLTAIISIKHPDP QFEGQTKTKLGNSEARTITDTLFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKA RELTRRKSALEISNLPGKLADCSSKDPSISELYIVEGDSAGGSAKQGRDRHFQAILPL RGKILNVEKARLDKILSNNEVRSMITALGTGIGEDFNLEKARYHKVVIMTDADVDGAH IRTLLLTFFYRYMRQIIENGYVYIAQPPLYKVQQGKRVEYAYNDKELEELLKTLPQTP KPGLQRYKGLGEMNATQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRN FIEANARYVKNLDI*" /label="gyrB CDS" gene 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /label="gyrB gene" promotor_-10 complement(6003..6021) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(6005) /Source="Nicolas_upshifts" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(6037..6042) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 6375..6584 /Source="Nicolas_S_feature" /locus_tag="new_6784_6993" /HighExp="Cold, H2O2, G180, Oxctl, G135, G150, Sw, dia15, LBGexp, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S6" CDS 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /EC_number="5.99.1.3" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901, 27557712" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901, 27557712; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit A)" /protein_id="NP_387888.1" /db_xref="EnsemblGenomes-Gn:BSU00070" /db_xref="EnsemblGenomes-Tr:CAB11783" /db_xref="GOA:P05653" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005743" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="PDB:4DDQ" /db_xref="SubtiList:BG10071" /db_xref="UniProtKB/Swiss-Prot:P05653" /translation="MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKP VHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYM LVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVM PSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDF PTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEK IADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL LALVDGQPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDA VISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKL IAELKDILANEYKVLEIIREELTEIKERFNDERRTEIVTSGLETIEDEDLIERENIVV TLTHNGYVKRLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKV YRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKR TSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMG RTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKT AKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEE HVATVALVEKNEEDENEEEQEEV*" /label="gyrA CDS" gene 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /label="gyrA gene" promotor_-35 8964..8967 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 8965 /Source="Nicolas_upshifts" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 8984..9001 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 9031 /Source="Nicolas_upshifts" /id="D2" /incds=0 /nref=251 /ntot=261 /MaxReadThrough="3.73971" /MaxDrop="8.1288" /score="33.5021066" /energy="-14.1" /TU="NA" /idTUdmin="U4" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 9095..9101 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 9115..9134 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 9120..9205 /Source="Nicolas_S_feature" /locus_tag="new_9529_9614" /HighExp="LBGstat, H2O2, Paraq, Oxctl, UNK1, LBGexp, LPhT, MG-0.2, MG 25, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S7" upshifts 9120 /Source="Nicolas_upshifts" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 9191..9198 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9207 /Source="Nicolas_upshifts" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 9213..9232 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" rRNA 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-16S rRNA" gene 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /label="rrnO-16S gene" tRNA 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ile tRNA" gene 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /label="trnO-Ile gene" tRNA 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ala tRNA" gene 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /label="trnO-Ala gene" rRNA 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-23S rRNA" gene 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /label="rrnO-23S gene" rRNA 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-5S rRNA" gene 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /label="rrnO-5S gene" S_feature 14402..15459 /Source="Nicolas_S_feature" /locus_tag="new_14811_15868" /HighExp="G180, T0.0H, T0.30H, G135, T-0.40H, LBGstat, Cold, Paraq, C30, Oxctl" /AntisenseName="yaaC" /AntisenseCor="-4.5985764709218099E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S8" CDS complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387889.1" /db_xref="EnsemblGenomes-Gn:BSU00080" /db_xref="EnsemblGenomes-Tr:CAB11784" /db_xref="InterPro:IPR026988" /db_xref="SubtiList:BG10072" /db_xref="UniProtKB/Swiss-Prot:P37526" /translation="MTYHEWKDLALFYSVESTQKFLEKVYILNGINDAKKNSFKNSER FIYFLKHAESFYKQAAYSPLEIKPILLFYGMAQLIKACLITRDPHYPSHTSVLAHGVT TRKRKKQNYCFSDDEVKIQRNGLCVHFMKHLFGQSDIVDERYTMKKLLMAIPELSDIF YFQQKERFMTKVEKDKNEIFVPEEVVINYKMSDSRFAEYMSHHYQWSFTKKNEHGLLF EISPQDKEPWTSTSLLFDMEKNQYYIPSQREQFLRLPEMTIHYLILYNVGMIARYETE WWYELLTQHISDDYVLIQQFLLVSEKKFPKYASQFLLHF*" /label="yaaC CDS" gene complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /label="yaaC gene" promotor_-35 15438..15445 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 15460..15479 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 15461 /Source="Nicolas_upshifts" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(15466) /Source="Nicolas_upshifts" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(15475..15486) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(15500..15506) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /EC_number="1.1.1.205" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1722815, 17611193, 1979163, 3125411, 8917437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1722815, 17611193, 1979163, 3125411, 8917437; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inosine-monophosphate dehydrogenase" /protein_id="NP_387890.1" /db_xref="EnsemblGenomes-Gn:BSU00090" /db_xref="EnsemblGenomes-Tr:CAB11785" /db_xref="GOA:P21879" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005990" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG10073" /db_xref="UniProtKB/Swiss-Prot:P21879" /translation="MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNI PVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFL TPDHQVFDAEHLMGKYRISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKE ELVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIH GRLIVGAAVGVTGDTMTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNI IAGNVATAEATRALIEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKH GKTIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMG SVAAMEKGSKDRYFQEENKKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKD LRALREEAQFIRMTGAGLRESHPHDVQITKESPNYTIS*" /label="guaB CDS" gene 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /label="guaB gene" downshifts complement(15510) /Source="Nicolas_upshifts" /id="D3" /incds=0 /nref=33 /ntot=102 /MaxReadThrough="1.81989" /MaxDrop="4.44626" /score="-6.76739893" /energy="-12.2" /TU="NA" /idTUdmin="U12" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(15536..15636) /Source="Nicolas_upshift_promotors" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(15576) /Source="Nicolas_upshifts" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(16829..17424) /Source="Nicolas_S_feature" /locus_tag="new_17238_17833_c" /HighExp="Etha, Gly, C30, Salt, S8, S6, HiTm, S7, Sw, C90" /AntisenseName="dacA" /AntisenseCor="-0.39306815699287101" /AntisenseRegPval="-10.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S9" downshifts 16960 /Source="Nicolas_upshifts" /id="D4" /incds=0 /nref=243 /ntot=277 /MaxReadThrough="3.34899" /MaxDrop="7.78161" /score="26.7620012" /energy="-10.6" /TU="NA" /idTUdmin="U10" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 17018..17022 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 17038..17057 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 17044..17124 /Source="Nicolas_S_feature" /locus_tag="new_17453_17533" /HighExp="C30, LBGstat, G180, G150, LBGexp, G135, Lbexp, Oxctl, dia0, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S10" upshifts 17044 /Source="Nicolas_upshifts" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /EC_number="3.4.16.4" /experiment="publication(s) with functional evidences, PMID:8370539, 9864321, 10383963, 21378199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8370539, 9864321, 10383963, 21378199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5)" /protein_id="NP_387891.1" /db_xref="EnsemblGenomes-Gn:BSU00100" /db_xref="EnsemblGenomes-Tr:CAB11786" /db_xref="GOA:P08750" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10074" /db_xref="UniProtKB/Swiss-Prot:P08750" /translation="MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAI MIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEIS QDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKE LGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETS SIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERN GMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGK EKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKD YGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF*" /label="dacA CDS" gene 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /label="dacA gene" promotor_-10 complement(17413..17431) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(17424) /Source="Nicolas_upshifts" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(17446..17452) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 18338 /Source="Nicolas_upshifts" /id="D5" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="6.76335" /MaxDrop="2.1925" /score="26.7620012" /energy="-10.6" /TU="U13" /idTUdmin="U10" /TUdmin=1364 /isTUend="FALSE" /label="downshifts" S_feature 18457..18565 /Source="Nicolas_S_feature" /locus_tag="new_18866_18974" /HighExp="C30, MG 15, MG 10, MG-0.1, MG 25, BMM, ferm, Cold, MG 60, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S11" promotor_-35 18535..18538 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 18553..18572 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 18567..18652 /Source="Nicolas_S_feature" /locus_tag="new_18976_19061" /HighExp="BMM, MG 25, SMM, MG 15, UNK1, MG 10, GM 150, MG-0.1, MG 150, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S12" upshifts 18567 /Source="Nicolas_upshifts" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /EC_number="4.3.3.6" /EC_number="4.-.-.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14762015, 15771487, 15911615, 16157873, 17144654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762015, 15771487, 15911615, 16157873, 17144654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, synthase subunit" /protein_id="NP_387892.1" /db_xref="EnsemblGenomes-Gn:BSU00110" /db_xref="EnsemblGenomes-Tr:CAB11787" /db_xref="GOA:P37527" /db_xref="InterPro:IPR001852" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033755" /db_xref="PDB:2NV1" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10075" /db_xref="UniProtKB/Swiss-Prot:P37527" /translation="MAQTGTERVKRGMAEMQKGGVIMDVINAEQAKIAEEAGAVAVMA LERVPADIRAAGGVARMADPTIVEEVMNAVSIPVMAKARIGHIVEARVLEAMGVDYID ESEVLTPADEEFHLNKNEYTVPFVCGCRDLGEATRRIAEGASMLRTKGEPGTGNIVEA VRHMRKVNAQVRKVVAMSEDELMTEAKNLGAPYELLLQIKKDGKLPVVNFAAGGVATP ADAALMMQLGADGVFVGSGIFKSDNPAKFAKAIVEATTHFTDYKLIAELSKELGTAMK GIEISNLLPEQRMQERGW*" /label="pdxS CDS" gene 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /label="pdxS gene" S_feature complement(18785..19514) /Source="Nicolas_S_feature" /locus_tag="new_19194_19923_c" /HighExp="S6, S8, S7, S5, S4, C30, S3, BT, C90, Gly" /AntisenseName="pdxS" /AntisenseCor="-0.65390240445415004" /AntisenseRegPval="-33.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S13" promotor_-10 complement(19502..19520) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(19514) /Source="Nicolas_upshifts" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(19536..19541) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-35" CDS 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 14762015, 15771487, 17144654, 18271580, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 14762015, 15771487, 17144654, 18271580, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, glutamine amidotransferase subunit PdxT" /protein_id="NP_387893.1" /db_xref="EnsemblGenomes-Gn:BSU00120" /db_xref="EnsemblGenomes-Tr:CAB11788" /db_xref="GOA:P37528" /db_xref="InterPro:IPR002161" /db_xref="InterPro:IPR021196" /db_xref="InterPro:IPR029062" /db_xref="PDB:1R9G" /db_xref="PDB:2NV0" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10076" /db_xref="UniProtKB/Swiss-Prot:P37528" /translation="MLTIGVLGLQGAVREHIHAIEACGAAGLVVKRPEQLNEVDGLIL PGGESTTMRRLIDTYQFMEPLREFAAQGKPMFGTCAGLIILAKEIAGSDNPHLGLLNV VVERNSFGRQVDSFEADLTIKGLDEPFTGVFIRAPHILEAGENVEVLSEHNGRIVAAK QGQFLGCSFHPELTEDHRVTQLFVEMVEEYKQKALV*" /label="pdxT CDS" gene 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /label="pdxT gene" misc_RNA 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /product="T-box riboswitch specific of serine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboS RNA" gene 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /label="tboS gene" downshifts 20379 /Source="Nicolas_upshifts" /id="D6" /incds=0 /nref=9 /ntot=80 /MaxReadThrough="7.14793" /MaxDrop="4.37654" /score="41.1243331" /energy="-23.3" /TU="U13,U15" /idTUdmin="U13" /TUdmin="-1347" /isTUend="FALSE" /label="downshifts" CDS 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /EC_number="6.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10546897, 12682299, 14732487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10546897, 12682299, 14732487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="seryl-tRNA synthetase" /protein_id="NP_387894.1" /db_xref="EnsemblGenomes-Gn:BSU00130" /db_xref="EnsemblGenomes-Tr:CAB11789" /db_xref="GOA:P37464" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002317" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR015866" /db_xref="InterPro:IPR033729" /db_xref="SubtiList:BG10077" /db_xref="UniProtKB/Swiss-Prot:P37464" /translation="MLDTKMLRANFQEIKAKLVHKGEDLTDFDKFEALDDRRRELIGK VEELKGKRNEVSQQVAVLKREKKDADHIIKEMREVGEEIKKLDEELRTVEAELDTILL SIPNIPHESVPVGETEDDNVEVRKWGEKPSFAYEPKPHWDIADELGILDFERAAKVTG SRFVFYKGLGARLERALYNFMLDLHVDEYNYTEVIPPYMVNRASMTGTGQLPKFEEDA FKIREEDYFLIPTAEVPITNMHRDEILSGDSLPINYAAFSACFRSEAGSAGRDTRGLI RQHQFNKVELVKFVKPEDSYEELEKLTNQAERVLQLLELPYRVMSMCTGDLGFTAAKK YDIEVWIPSQDTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRT VAAILENYQQEDGSVVIPKVLRPYMGNREVMKP*" /label="serS CDS" gene 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /label="serS gene" downshifts 21726 /Source="Nicolas_upshifts" /id="D7" /incds=0 /nref=234 /ntot=255 /MaxReadThrough="0.83411" /MaxDrop="7.38039" /score="17.6549558" /energy="-13.3" /TU="NA" /idTUdmin="U13" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 21837..21844 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 21859..21878 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 21859 /Source="Nicolas_upshifts" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="upshifts" tRNA 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(UGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Ser1 tRNA" gene 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /label="trnSL-Ser1 gene" downshifts 21998 /Source="Nicolas_upshifts" /id="D8" /incds=0 /nref=168 /ntot=196 /MaxReadThrough="5.02201" /MaxDrop="8.36635" /score="29.7083093" /energy="-12.4" /TU="U17" /idTUdmin="U13" /TUdmin=272 /isTUend="FALSE" /label="downshifts" S_feature 22043..22120 /Source="Nicolas_S_feature" /locus_tag="new_22452_22529" /HighExp="Cold, H2O2, G180, Paraq, Oxctl, C30, G150, G135, BMM, Heat" /AntisenseName="dck" /AntisenseCor="0.61769771609764101" /AntisenseRegPval="-29" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S14" CDS complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /EC_number="2.7.1.76" /EC_number="2.7.1.74" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6251049, 11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6251049, 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyadenosine/deoxycytidine kinase" /protein_id="NP_387895.1" /db_xref="EnsemblGenomes-Gn:BSU00140" /db_xref="EnsemblGenomes-Tr:CAB11790" /db_xref="GOA:P37529" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10078" /db_xref="UniProtKB/Swiss-Prot:P37529" /translation="MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDH NPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEAGGGFVQDRSIYEDTGIFAKMHA DKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTS RSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK* " /label="dck CDS" gene complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /label="dck gene" promotor_-35 22106..22112 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(22111) /Source="Nicolas_upshifts" /id="D9" /incds=0 /nref=88 /ntot=213 /MaxReadThrough="1.96668" /MaxDrop="4.49235" /score="14.5948578" /energy="-11" /TU="NA" /idTUdmin="U19" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 22122..22758 /Source="Nicolas_S_feature" /locus_tag="new_22531_23167" /HighExp="G180, G135, Cold, C30, Paraq, H2O2, Oxctl, G150, S5, S6" /AntisenseName="dck" /AntisenseCor="0.15155468296621499" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S15" upshifts 22122 /Source="Nicolas_upshifts" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 22126..22137 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /EC_number="2.7.1.113" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyguanosine kinase" /protein_id="NP_387896.1" /db_xref="EnsemblGenomes-Gn:BSU00150" /db_xref="EnsemblGenomes-Tr:CAB11791" /db_xref="GOA:P37530" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10079" /db_xref="UniProtKB/Swiss-Prot:P37530" /translation="MNTAPFIAIEGPIGAGKTTLATMLSQKFGFPMINEIVEDNPYLD KFYDNIKEWSFQLEMFFLCHRYKQLEDTSDHFLKKGQPVIADYHIYKNVIFAERTLSP HQLEKYKKIYHLLTDDLPKPNFIIYIKASLPTLLHRIEKRGRPFEKKIETSYLEQLIS DYEVAIKQLQEADPELTVLTVDGDSKDFVLNKSDFERIAAHVKELIV*" /label="dgk CDS" gene complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /label="dgk gene" promotor_-10 complement(23401..23420) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(23419) /Source="Nicolas_upshifts" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(23436..23440) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /EC_number="3.2.1.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11011148, 11737650, 12177332, 10419957, 18456807, 18835992, 19933362, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore peptidoglycan N-acetylglucosaminidase" /protein_id="NP_387897.1" /db_xref="EnsemblGenomes-Gn:BSU00160" /db_xref="EnsemblGenomes-Tr:CAB11792" /db_xref="GOA:P37531" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10080" /db_xref="UniProtKB/Swiss-Prot:P37531" /translation="MVKQGDTLSAIASQYRTTTNDITETNEIPNPDSLVVGQTIVIPI AGQFYDVKRGDTLTSIARQFNTTAAELARVNRIQLNTVLQIGFRLYIPPAPKRDIESN AYLEPRGNQVSENLQQAAREASPYLTYLGAFSFQAQRNGTLVAPPLTNLRSITESQNT TLMMIITNLENQAFSDELGRILLNDETVKRRLLNEIVENARRYGFRDIHFDFEYLRPQ DREAYNQFLREARDLFHREGLEISTALAPKTSATQQGRWYEAHDYRAHGEIVDFVVLM TYEWGYSGGPPQAVSPIGPVRDVIEYALTEMPANKIVMGQNLYGYDWTLPYTAGGTPA RAVSPQQAIVIADQNNASIQYDQTAQAPFFRYTDAENRRHEVWFEDARSIQAKFNLIK ELNLRGISYWKLGLSFPQNWLLLSDQFNVVKKTFR*" /label="sleL CDS" gene complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /label="sleL gene" downshifts complement(23496) /Source="Nicolas_upshifts" /id="D10" /incds=0 /nref=40 /ntot=61 /MaxReadThrough="1.17442" /MaxDrop="6.30997" /score="3.66560192" /energy="-8.4" /TU="NA" /idTUdmin="U20" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(24773..24791) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(24794) /Source="Nicolas_upshifts" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(24807..24812) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2521622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidase (isochorismatase family)" /protein_id="NP_387898.1" /db_xref="EnsemblGenomes-Gn:BSU00170" /db_xref="EnsemblGenomes-Tr:CAB11793" /db_xref="GOA:P37532" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG10081" /db_xref="UniProtKB/Swiss-Prot:P37532" /translation="MSKADKALLIVDMINNFEFDMGETLAKKTEKIVPHILSLKEHAR QNEWPIIYINDHYGLWQADIKNIQQECTNERSKDIITKIAPVDADYFLIKPKHSAFYE TALHTLLTELQVRHIIITGIAGNICVLFTANDAYMREYSITIPKDCIASNSDEDNEFA LTMMENVLFAEITTEEQIIEK*" /label="yaaI CDS" gene complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /label="yaaI gene" promotor_-35 25223..25227 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25242..25261 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" S_feature 25246..25442 /Source="Nicolas_S_feature" /locus_tag="new_25655_25851" /HighExp="Diami, dia5, H2O2, dia15, T0.30H, T-0.40H, HiOs, T-1.10H, Salt, T0.0H" /AntisenseName="yaaI" /AntisenseCor="9.6546810160837798E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S16" upshifts 25248 /Source="Nicolas_upshifts" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" promotor_-10 complement(25382..25400) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25401) /Source="Nicolas_upshifts" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(25415..25421) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /EC_number="3.5.4.33" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15677468, 16014871, 16415880, 16700551, 23658230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA specific adenosine A34 deaminase" /protein_id="NP_387899.1" /db_xref="EnsemblGenomes-Gn:BSU00180" /db_xref="EnsemblGenomes-Tr:CAB11794" /db_xref="GOA:P21335" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR028883" /db_xref="SubtiList:BG10082" /db_xref="UniProtKB/Swiss-Prot:P21335" /translation="MTQDELYMKEAIKEAKKAEEKGEVPIGAVLVINGEIIARAHNLR ETEQRSIAHAEMLVIDEACKALGTWRLEGATLYVTLEPCPMCAGAVVLSRVEKVVFGA FDPKGGCSGTLMNLLQEERFNHQAEVVSGVLEEECGGMLSAFFRELRKKKKAARKNLS E*" /label="tadA CDS" gene 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /label="tadA gene" promotor_-35 25932..25938 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25952..25971 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" misc_RNA 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /product="small cytoplasmic RNA (scRNA, 4.5S RNA), signal recognition particle-like (SRP) component" /experiment="publication(s) with functional evidences, PMID:1372600, 1689715" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1372600, 1689715" /label="scr RNA" gene 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /label="scr gene" S_feature 25974..26123 /Source="Nicolas_S_feature" /locus_tag="new_26383_26532" /HighExp="T1.0H, T5.0H, T1.30H, T3.30H, T3.0H, T2.30H, T4.0H, S8, T-1.10H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S17" upshifts 25974 /Source="Nicolas_upshifts" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" S_feature 26227..26322 /Source="Nicolas_S_feature" /locus_tag="new_26636_26731" /HighExp="S8, Sw, B60, B36, T2.30H, T3.30H, T1.0H, BC, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S18" downshifts 26279 /Source="Nicolas_upshifts" /id="D11" /incds=0 /nref=273 /ntot=278 /MaxReadThrough="4.46774" /MaxDrop="8.31255" /score="23.257527" /energy="-10.3" /TU="U21,U23" /idTUdmin="U21" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 26343..26346 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 26361..26380 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 26370 /Source="Nicolas_upshifts" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III subunit tau subunit" /protein_id="NP_387900.2" /db_xref="EnsemblGenomes-Gn:BSU00190" /db_xref="EnsemblGenomes-Tr:CAB11795" /db_xref="GOA:P09122" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR012763" /db_xref="InterPro:IPR022754" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10083" /db_xref="UniProtKB/Swiss-Prot:P09122" /translation="MSYQALYRVFRPQRFEDVVGQEHITKTLQNALLQKKFSHAYLFS GPRGTGKTSAAKIFAKAVNCEHAPVDEPCNECAACKGITNGSISDVIEIDAASNNGVD EIRDIRDKVKFAPSAVTYKVYIIDEVHMLSIGAFNALLKTLEEPPEHCIFILATTEPH KIPLTIISRCQRFDFKRITSQAIVGRMNKIVDAEQLQVEEGSLEIIASAADGGMRDAL SLLDQAISFSGDILKVEDALLITGAVSQLYIGKLAKSLHDKNVSDALETLNELLQQGK DPAKLIEDMIFYFRDMLLYKTAPGLEGVLEKVKVDETFRELSEQIPAQALYEMIDILN KSHQEMKWTNHPRIFFEVAVVKICQTSHQSAADLPEVDMLMKKIQQLEQEVERLKTTG IKAAAESPKKEAPRVPKGGKSNYKAPVGRIHEILKEATRPDLDLLRNSWGKLLAHLKQ QNKVSHAALLNDSEPVAAGSAAFVLKFKYEIHCKMVAEDNNGVRTNLEQILESMLGKR MDLIGVPEAQWGKIREEFLEDHQQENEGSNEPAEEDPLIAEAKKLVGADLIEIKD*" /label="dnaX CDS" gene 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /label="dnaX gene" promotor_-35 27937..27944 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 27959..27978 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 27974 /Source="Nicolas_upshifts" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16740939, 19208644, 19594923, 20639362, 22333191, 22544270; Product type f : factor" /codon_start=1 /transl_table=11 /product="nucleoid associated protein" /protein_id="NP_387901.1" /db_xref="EnsemblGenomes-Gn:BSU00200" /db_xref="EnsemblGenomes-Tr:CAB11796" /db_xref="GOA:P24281" /db_xref="InterPro:IPR004401" /db_xref="InterPro:IPR036894" /db_xref="SubtiList:BG10084" /db_xref="UniProtKB/Swiss-Prot:P24281" /translation="MRGGMGNMQKMMKQMQKMQKDMAKAQEELAEKVVEGTAGGGMVT VKANGQKEILDVIIKEEVVDPEDIDMLQDLVLAATNEALKKVDEITNETMGQFTKGMN MPGLF*" /label="ebfC CDS" gene 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /label="ebfC gene" CDS 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12065426, 24285298, 24891441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065426, 24285298, 24891441; Product type f: factor" /codon_start=1 /transl_table=11 /product="recA filament-DNA complex stabilisation factor" /protein_id="NP_387902.1" /db_xref="EnsemblGenomes-Gn:BSU00210" /db_xref="EnsemblGenomes-Tr:CAB11797" /db_xref="GOA:P24277" /db_xref="InterPro:IPR000093" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR015967" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR023627" /db_xref="InterPro:IPR023628" /db_xref="InterPro:IPR034137" /db_xref="SubtiList:BG10085" /db_xref="UniProtKB/Swiss-Prot:P24277" /translation="MQYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLGMKEDVVLDFA KALVNAKRNLTYCSVCGHITDQDPCYICEDTRRDKSVICVVQDPKDVIAMEKMKEYNG QYHVLHGAISPMDGIGPEDIKIPELLKRLQDDQVTEVILATNPNIEGEATAMYISRLL KPSGIKLSRIAHGLPVGGDLEYADEVTLSKALEGRREL*" /label="recR CDS" gene 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /label="recR gene" CDS 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387903.1" /db_xref="EnsemblGenomes-Gn:BSU00220" /db_xref="EnsemblGenomes-Tr:CAB11798" /db_xref="InterPro:IPR019644" /db_xref="SubtiList:BG10086" /db_xref="UniProtKB/Swiss-Prot:P37533" /translation="MGFLRKKTLRREFDEKLTEQLFKQKEEWNRQKKLVEKSLEPSAE VLYELKVAEAKYFFYLREAKQRNLKISRWK*" /label="yaaL CDS" gene 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /label="yaaL gene" promotor_-35 29299..29304 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-35" upshifts 29316 /Source="Nicolas_upshifts" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="upshifts" promotor_-10 29320..29338 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-10" CDS 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15087499, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15087499, 17557826; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the pro-sigma(K) processing machinery" /protein_id="NP_387904.2" /db_xref="EnsemblGenomes-Gn:BSU00230" /db_xref="EnsemblGenomes-Tr:CAB11799" /db_xref="GOA:P24282" /db_xref="InterPro:IPR010001" /db_xref="SubtiList:BG10087" /db_xref="UniProtKB/Swiss-Prot:P24282" /translation="MEPIFIIGIILGLVILLFLSGSAAKPLKWIGITAVKFVAGALLL VCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFII*" /label="bofA CDS" gene 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /label="bofA gene" promotor_-35 29639..29646 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 29660..29679 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 29667..29869 /Source="Nicolas_S_feature" /locus_tag="new_30076_30278" /HighExp="LBGstat, Diami, C30, H2O2, Oxctl, HPh, BMM, GM 120, Paraq, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.899, 0.99" /label="S19" upshifts 29667 /Source="Nicolas_upshifts" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-16S" gene 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /label="rrnA-16S gene" tRNA 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ile(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ile" gene 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /label="trnA-Ile gene" tRNA 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ala" gene 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /label="trnA-Ala gene" rRNA 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-23S" gene 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /label="rrnA-23S gene" S_feature 34695..34827 /Source="Nicolas_S_feature" /locus_tag="new_35104_35236" /HighExp="LBGstat, G135, Oxctl, C30, HPh, Paraq, G180, LPh, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S20" rRNA 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-5S" gene 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /label="rrnA-5S gene" S_feature 34947..35049 /Source="Nicolas_S_feature" /locus_tag="new_35356_35458" /HighExp="Oxctl, Paraq, H2O2, LBGstat, C30, G180, Cold, G135, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S21" promotor_-35 35010..35018 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-35" promotor_-10 35032..35051 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-10" upshifts 35051 /Source="Nicolas_upshifts" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="upshifts" CDS 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8759874, 15044948, 21935351, 26929302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759874, 15044948, 21935351, 26929302; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="forespore-specific anti-sigma factor" /protein_id="NP_387905.1" /db_xref="EnsemblGenomes-Gn:BSU00240" /db_xref="EnsemblGenomes-Tr:CAB11800" /db_xref="GOA:P37534" /db_xref="InterPro:IPR019700" /db_xref="SubtiList:BG10088" /db_xref="UniProtKB/Swiss-Prot:P37534" /translation="MDETVKLNHTCVICDQEKNRGIHLYTKFICLDCERKVISTSTSD PDYAFYVKKLKSIHTPPLYS*" /label="csfB CDS" gene 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /label="csfB gene" downshifts 35300 /Source="Nicolas_upshifts" /id="D12" /incds=0 /nref=79 /ntot=215 /MaxReadThrough="5.37774" /MaxDrop="4.42494" /score="22.3916007" /energy="-6.7" /TU="U28" /idTUdmin="U27" /TUdmin=3938 /isTUend="FALSE" /label="downshifts" promotor_-35 35361..35370 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 35382..35397 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 35388 /Source="Nicolas_upshifts" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23155385; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatase" /protein_id="NP_387906.1" /db_xref="EnsemblGenomes-Gn:BSU00250" /db_xref="EnsemblGenomes-Tr:CAB11801" /db_xref="GOA:P37467" /db_xref="InterPro:IPR018770" /db_xref="SubtiList:BG10089" /db_xref="UniProtKB/Swiss-Prot:P37467" /translation="MQRFFHFLVWSLTSSATFVFIGILSFFGLNQSIFLSIVYGLASG AAVYIAGIWNARRLFLKKHELTGREYAYIKKNLEEARQKMVRLRKALFQAKSIQMFKQ NAEMLRIVRRIYLLTKKEPKRFYQAERFFYQTLDSVVELTEKYAFLSSHPKKSKELSM SLSETRITLTELTKRLEEDLTQAMGDEIDELQFELDAAKHSLKK*" /label="xpaC CDS" gene 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /label="xpaC gene" CDS 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12533473, 20713661" /codon_start=1 /transl_table=11 /product="putative toxic compound resistance protein" /protein_id="NP_387907.1" /db_xref="EnsemblGenomes-Gn:BSU00260" /db_xref="EnsemblGenomes-Tr:CAB11802" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG10090" /db_xref="UniProtKB/Swiss-Prot:P37535" /translation="MNRDQSDLHIDELLADPFGGNIEIPGSEAVKAEKEQVRLVDVLP EENKEKAIQLAGQIDHKNMQSIVLYGSQAQSKLLNFSHDMINHVQKKDVGEIGEILGE LMKKLEQVNPDDLQSKKKGFLARMFGRVSSSLQEVLSKYQKTSVQIDRISLKLEHSKN ALISDNKLLEQLYEKNKEYFAALNVYIAAGELKLEELKTKTIPELKQQAESSDHNQMA VQEVNDLIQFADRLDKRVHDLLLSRQITIQSAPQIRLIQNTNQALAEKIQSSIVTAIP LWKNQVAIALTLLRQRNAVDAQQKVSDTTNELLLKNAELLKTNTIETARANERGLVDI DTLKKVQESLISTLEETLTIQEEGRIKRRQAEEELMMMEGDLKQKLITIKER*" /label="yaaN CDS" gene 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /label="yaaN gene" S_feature 37230..37310 /Source="Nicolas_S_feature" /locus_tag="new_37639_37719" /HighExp="T0.0H, T-0.40H, T0.30H, T-1.10H, T-1.40H, Salt, T1.0H, G150, Diami, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="0.984, 0.715" /TUlongSig="NA" /TUlongPSig="NA" /label="S22" CDS 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9723923, 20876533, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative decarboxylase" /protein_id="NP_387908.1" /db_xref="EnsemblGenomes-Gn:BSU00270" /db_xref="EnsemblGenomes-Tr:CAB11803" /db_xref="GOA:P37536" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10091" /db_xref="UniProtKB/Swiss-Prot:P37536" /translation="MNTPLYKALIQHARRNSHSFHVPGHHNGDVFFDDAKSIFDPLLT IDVTELAGLDDLHHPSGVIKEAQELASQLYGSAESFFLVNGTTVGNLAMILSVCEPGD TILVQRNCHKSVFHAVDLSGAEPVYLAPDVDSAMHVPTHVPLGTIKEALEAYPDAKGL VLTNPTYYGHSADLTEIITEAHHYGIPVLVDEAHGAHFILGEPFPVSALKMGADIVVQ SAHKTLPAMTMGSYLHLNSSCRINRDRVAEYLNRLQSSSPSYPIMASLDIARAYVQHI IEEQKLSDILQRIETLKQTFDSLTNAEAVNPANPLIITDPLKLTIRSKRGHSGYTLQS ILERANIFTELADENQVLLVLPLGGKRRINAEIIRSIDEEIEKTPPDQTFVSAEWGVQ PVTVLPYPKKVLHSFKKEYVSFEEAAGRLNAEDIIPYPPGIPMIMAGERITKESVQKL SRLISMKTHVQGNMKIKEKQLLVYIEEEKS*" /label="yaaO CDS" gene 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /label="yaaO gene" promotor_-35 38673..38679 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-35" promotor_-10 38694..38712 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-10" upshifts 38703 /Source="Nicolas_upshifts" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="upshifts" CDS 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /EC_number="2.7.4.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696781, 12682299, 18523102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696781, 12682299, 18523102; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate kinase" /protein_id="NP_387909.2" /db_xref="EnsemblGenomes-Gn:BSU00280" /db_xref="EnsemblGenomes-Tr:CAB11804" /db_xref="GOA:P37537" /db_xref="InterPro:IPR018094" /db_xref="InterPro:IPR018095" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10092" /db_xref="UniProtKB/Swiss-Prot:P37537" /translation="MSGLFITFEGPEGAGKTTVLQEIKNILTAEGLQVMATREPGGID IAEQIREVILNENNILMDPKTEALLYAAARRQHLVEKVKPALEQGFIVLCDRFIDSSL AYQGYARGLGIDEVLSINEFAIGDMMPHVTVYFSIDPEEGLKRIYANGSREKNRLDLE KLDFHTKVQEGYQELMKRFPERFHSVDAGQSKDLVVQDVLKVIDEALKKIQL*" /label="tmk CDS" gene 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /label="tmk gene" promotor_-35 39383..39390 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 39403..39422 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 39414 /Source="Nicolas_upshifts" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /experiment="publication(s) with functional evidences, PMID:10913081, 25433025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 25433025; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal transduction receptor, cyclic di-AMP binding" /protein_id="NP_387910.1" /db_xref="EnsemblGenomes-Gn:BSU00290" /db_xref="EnsemblGenomes-Tr:CAB11805" /db_xref="InterPro:IPR010375" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="PDB:4RLE" /db_xref="SubtiList:BG10093" /db_xref="UniProtKB/Swiss-Prot:P37538" /translation="MKLIVAVVQDQDSNRLLKTLTDHNFRVTKLATTGGFLKSGNTTF MIGVEDIRVNKALSLIKENGQKRDQMIAPVSPMGGNADSYVPYPVEVEVGGATVFVLP VDEFHQF*" /label="darA CDS" gene 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /label="darA gene" CDS 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387911.1" /db_xref="EnsemblGenomes-Gn:BSU00300" /db_xref="EnsemblGenomes-Tr:CAB11806" /db_xref="InterPro:IPR005585" /db_xref="InterPro:IPR024042" /db_xref="SubtiList:BG10094" /db_xref="UniProtKB/Swiss-Prot:P37539" /translation="MKINKDIRTFIDNKQIPSVKTSEITASFKTSMENQSSKMKLDQL TRLLSDIEAFGKRLTKSRNFKDLARFKGLVKRFVKEAVDSGLSHETSKSFDLYGNSRT LGLVKEIDDKLIQLTEEMMDQEKPAIDLLERIGEIKGLLINLYT*" /label="yaaR CDS" gene 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /label="yaaR gene" CDS 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8509334, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509334, 12060778, 12682299, 22333191, 23525462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III clamp loader delta' subunit" /protein_id="NP_387912.1" /db_xref="EnsemblGenomes-Gn:BSU00310" /db_xref="EnsemblGenomes-Tr:CAB11807" /db_xref="GOA:P37540" /db_xref="InterPro:IPR004622" /db_xref="InterPro:IPR015199" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10095" /db_xref="UniProtKB/Swiss-Prot:P37540" /translation="MAISWKEMNELQPRVMKLLYNSIEKDRLSHAYLFEGKKGTGKLD AALLLAKSFFCLEGGAEPCESCRNCKRIESGNHPDLHLVQPDGLSIKKAQIQALQEEF SKTGLESHKKLYIISHADQMTANAANSLLKFLEEPNKDTMAVLITEQPQRLLDTIISR CQTLPFQPLQPKAIEDRLIEQDVSPHMARLLANMTNNVAEAVELSRNDEFAESRAKVI KLYEVLHQRKGHAFFFIQDQWMPFFKEKTHQEMGLDMLLLIYRDVLSIQIGNEDKLIY QDLFQSIKQHALQSTQQSVTNQILAVLEAKKRLHSNVNVQGLMEHLVLMLQEG*" /label="holB CDS" gene 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /label="holB gene" CDS 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12270811, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12270811, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex of RNaseY (RicAFT complex /FAD / two [4Fe-4S]2+)" /protein_id="NP_387913.1" /db_xref="EnsemblGenomes-Gn:BSU00320" /db_xref="EnsemblGenomes-Tr:CAB11808" /db_xref="GOA:P37541" /db_xref="InterPro:IPR007557" /db_xref="SubtiList:BG10096" /db_xref="UniProtKB/Swiss-Prot:P37541" /translation="MYNVIGVRFKKAGKIYYFDPNGFHIEHDSCVIVETVRGVEYGQV VIANKQVDEHDVVLPLRKVIRVADDRDLLIVEENKQEALSAFDICQKKVIEHGLDMKL VDVEFTFDRNKVIFYFTADGRVDFRELVKDLASIFKTRIELRQIGVRDEAKMLGGIGP CGRMLCCSTFLGDFEPVSIKMAKDQNLSLNPTKISGLCGRLMCCLKYENDEYETAKEQ LPDIGEMITTANGPAKVVGLNILERVLQVELINREKVIEYTWEELLEEGVVSAQTTD* " /label="ricT CDS" gene 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /label="ricT gene" CDS 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15927750, 16461910, 19737352, 21895792, 23909787, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15927750, 16461910, 19737352, 21895792, 23909787, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="subunit of the DNA replication complex" /protein_id="NP_387914.1" /db_xref="EnsemblGenomes-Gn:BSU00330" /db_xref="EnsemblGenomes-Tr:CAB11809" /db_xref="GOA:P37542" /db_xref="InterPro:IPR010377" /db_xref="PDB:5DOL" /db_xref="SubtiList:BG10097" /db_xref="UniProtKB/Swiss-Prot:P37542" /translation="MDKKELFDTVINLEEQIGSLYRQLGDLKQHIGEMIEENHHLQLE NKHLRKRLDDTTQQIEKFKADKKESKTQKTEQTDIGEGYDNLARLYQEGFHICNVHYG SVRKEDCLFCLSFLNKK*" /label="dnaH CDS" gene 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /label="dnaH gene" CDS 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /EC_number="2.1.1.223" /function="10.3: tRNA and rRNA base modification" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22905870, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase" /protein_id="NP_387915.1" /db_xref="EnsemblGenomes-Gn:BSU00340" /db_xref="EnsemblGenomes-Tr:CAB11810" /db_xref="GOA:P37543" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10098" /db_xref="UniProtKB/Swiss-Prot:P37543" /translation="MVSLHDDERLDYLLAEDMKIIQSPTVFAFSLDAVLLSKFAYVPI QKGKIVDLCTGNGIVPLLLSTRSKADILGVEIQERLHDMAVRSVEYNKLDDQIQIIHD DLKNMPEKLGHNRYDVVTCNPPYFKTPKQTEQNMNEHLRIARHEIHCTLEDVISVSSK LLKQGGKAALVHRPGRLLEIFELMKAYQIEPKRVQFVYPKQGKEANTILVEGIKGGRP DLKILPPLFVYDEQNEYTKEIRTILYGDK*" /label="trmNF CDS" gene 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /label="trmNF gene" CDS 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11483577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UvrC-Intron-type (URI) endonuclease" /protein_id="NP_387916.1" /db_xref="EnsemblGenomes-Gn:BSU00350" /db_xref="EnsemblGenomes-Tr:CAB11811" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG12700" /db_xref="UniProtKB/Swiss-Prot:O31414" /translation="METNNHFFYVVKCKDNSWYAGYTNDLHKRVKTHNDGKGAKYTKV RRPVELIFAESFSTKREAMQAEYYFKKLTRKKKELYIEEKRNSKEAVYVKAPNEL*" /label="yazA CDS" gene 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /label="yazA gene" CDS 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /EC_number="2.1.1.198" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 19965768, 25893373; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA 2'-O-ribose C1402 methyltransferase" /protein_id="NP_387917.1" /db_xref="EnsemblGenomes-Gn:BSU00360" /db_xref="EnsemblGenomes-Tr:CAB11812" /db_xref="GOA:P37544" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR008189" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR018063" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10099" /db_xref="UniProtKB/Swiss-Prot:P37544" /translation="MLRRQMSFNGKSDMGILYLVPTPIGNLEDMTFRAIDTLKSVDAI AAEDTRQTKKLCHVYEIETPLVSYHEHNKESSGHKIIEWLKSGKNIALVSDAGLPTIS DPGAEIVKDFTDIGGYVVPLPGANAALTALIASGIVPQPFFFYGFLNRQKKEKKKELE ALKKRQETIIFYEAPHRLKETLSAMAEILGDREIAVTRELTKKYEEFIRGTISEVIGW ANEDQIRGEFCLVVEGSNNEEVDEEEQWWETLTAKEHVEHYISKGATSKEAIKKAAVD RNVPKREVYDAYHIKQ*" /label="rsmI CDS" gene 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /label="rsmI gene" downshifts 44363 /Source="Nicolas_upshifts" /id="D13" /incds=0 /nref=23 /ntot=177 /MaxReadThrough="3.33195" /MaxDrop="3.72723" /score="5.97354542" /energy="-10.2" /TU="U29,U31" /idTUdmin="U29" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for transition state genes (AbrB-SurF)" /protein_id="NP_387918.1" /db_xref="EnsemblGenomes-Gn:BSU00370" /db_xref="EnsemblGenomes-Tr:CAB11813" /db_xref="GOA:P08874" /db_xref="InterPro:IPR007159" /db_xref="PDB:1YFB" /db_xref="PDB:1YSF" /db_xref="PDB:1Z0R" /db_xref="PDB:2K1N" /db_xref="PDB:2MJG" /db_xref="PDB:2RO4" /db_xref="SubtiList:BG10100" /db_xref="UniProtKB/Swiss-Prot:P08874" /translation="MFMKSTGIVRKVDELGRVVIPIELRRTLGIAEKDALEIYVDDEK IILKKYKPNMTCQVTGEVSDDNLKLAGGKLVLSKEGAEQIISEIQNQLQNLK*" /label="abrB CDS" gene complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /label="abrB gene" downshifts complement(44441) /Source="Nicolas_upshifts" /id="D14" /incds=0 /nref=216 /ntot=263 /MaxReadThrough="2.17237" /MaxDrop="7.75729" /score="20.9582436" /energy="-10.2" /TU="U32" /idTUdmin="U32" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 44760 /Source="Nicolas_upshifts" /id="D15" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="2.53543" /MaxDrop="4.31699" /score="13.7153159" /energy="-14.4" /TU="NA" /idTUdmin="U29" /TUdmin=374 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(44796..44815) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(44813) /Source="Nicolas_upshifts" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(44815..44990) /Source="Nicolas_S_feature" /locus_tag="new_45224_45399_c" /HighExp="C30, H2O2, G180, Etha, S0, GM 25, Gly, G135, MG 25, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S23" promotor_-35 complement(44829..44836) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(44986..45005) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-10" upshifts complement(44990) /Source="Nicolas_upshifts" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="upshifts" promotor_-35 complement(45019..45026) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-35" promotor_-35 45090..45094 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-35" promotor_-10 45109..45128 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-10" S_feature 45115..45223 /Source="Nicolas_S_feature" /locus_tag="new_45524_45632" /HighExp="LBGtran, Heat, dia5, dia15, LBGexp, Lbexp, dia0, H2O2, Diami, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S24" upshifts 45115 /Source="Nicolas_upshifts" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="upshifts" CDS 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /EC_number="6.1.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11233169, 12682299, 12792655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA synthetase" /protein_id="NP_387919.1" /db_xref="EnsemblGenomes-Gn:BSU00380" /db_xref="EnsemblGenomes-Tr:CAB11814" /db_xref="GOA:P37465" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004495" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014758" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR023457" /db_xref="InterPro:IPR033911" /db_xref="SubtiList:BG10101" /db_xref="UniProtKB/Swiss-Prot:P37465" /translation="MPQENNTFYITTPIYYPSGKLHIGHAYTTVAGDAMARYKRLKGF DVRYLTGTDEHGQKIQQKAEQENITPQEYVDRAAADIQKLWKQLEISNDDFIRTTEKR HKVVIEKVFQKLLDNGDIYLDEYEGWYSIPDETFYTETQLVDIERNEKGEVIGGKSPD SGHPVELIKEESYFFRMGKYADRLLKYYEENPTFIQPESRKNEMINNFIKPGLEDLAV SRTTFDWGVKVPENPKHVVYVWIDALFNYLTALGYDTENDELYQKYWPADVHLVGKEI VRFHTIYWPIMLMALDLPLPKQVFAHGWLLMKDGKMSKSKGNVVDPVTLIERYGLDEL RYYLLREVPFGSDGVFTPEGFVERINYDLANDLGNLLNRTVAMINKYFDGQIGSYKGA VTEFDHTLTSVAEETVKAYEKAMENMEFSVALSTLWQLISRTNKYIDETAPWVLAKDP AKEEELRSVMYHLAESLRISAVLLQPFLTKTPEKMFEQLGITDESLKAWDSITAFGQL KDTKVQKGEPLFPRLEAEEEIAYIKGKMQGSAPAKEETKEEEPQEVDRLPEITIDQFM DVELRVAEVIEAEPVKKADRLLKLQLDLGFEKRQVVSGIAKHYTPEELVGKKLVCVTN LKPVKLRGELSQGMILAGEADGVLKVVSIDQSLPKGTRIK*" /label="metS CDS" gene 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /label="metS gene" promotor_-10 complement(45972..45991) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(45980) /Source="Nicolas_upshifts" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(46007..46011) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 47202 /Source="Nicolas_upshifts" /id="D16" /incds=0 /nref=18 /ntot=206 /MaxReadThrough="4.8491" /MaxDrop="2.9167" /score="13.7153159" /energy="-14.4" /TU="U34" /idTUdmin="U34" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" S_feature complement(47264..49610) /Source="Nicolas_S_feature" /locus_tag="new_47673_50019_c" /HighExp="T0.30H, T1.0H, T1.30H, Salt, C30, T2.0H, T-0.40H, T0.0H, T2.30H, T-1.10H" /AntisenseName="yabE" /AntisenseCor="-0.28154713646185298" /AntisenseRegPval="-5.6" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S25" CDS 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10747959, 16014871, 16461678, 19332551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acyl-tRNA deacylase" /protein_id="NP_387920.1" /db_xref="EnsemblGenomes-Gn:BSU00390" /db_xref="EnsemblGenomes-Tr:CAB11815" /db_xref="GOA:P37545" /db_xref="InterPro:IPR001130" /db_xref="InterPro:IPR015991" /db_xref="InterPro:IPR018228" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10102" /db_xref="UniProtKB/Swiss-Prot:P37545" /translation="MLFDTHAHLNAEQYDTDLEEVIERAKAEKVERIVVVGFDRPTIT RAMEMIEEYDFIYAAIGWHPVDAIDMTEEDLAWIKELSAHEKVVAIGEMGLDYHWDKS PKDIQKEVFRNQIALAKEVNLPIIIHNRDATEDVVTILKEEGAEAVGGIMHCFTGSAE VARECMKMNFYLSFGGPVTFKNAKKPKEVVKEIPNDRLLIETDCPFLTPHPFRGKRNE PSYVKYVAEQIAELKEMTFEEIASITTENAKRLFRIN*" /label="dayD CDS" gene 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /label="dayD gene" S_feature 48065..48145 /Source="Nicolas_S_feature" /locus_tag="new_48474_48554" /HighExp="Heat, C30, LBGtran, LBGstat, C90, Etha, M40t45, LPhT, MG 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S26" promotor_-35 48122..48127 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 48143..48161 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 48147 /Source="Nicolas_upshifts" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 48172..48175 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-35" promotor_-10 48190..48209 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-10" upshifts 48207 /Source="Nicolas_upshifts" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="upshifts" CDS 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15774001, 19047346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall shaping enzyme" /protein_id="NP_387921.1" /db_xref="EnsemblGenomes-Gn:BSU00400" /db_xref="EnsemblGenomes-Tr:CAB11816" /db_xref="GOA:P37546" /db_xref="InterPro:IPR007137" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR011098" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG10103" /db_xref="UniProtKB/Swiss-Prot:P37546" /translation="MGEREGRVDSLLDTLYNLSEEKEAFFITQKMKKLFSVKLSKSKV ILVAACLLLAGSGTAYAAHELTKQSVSVSINGKKKHIRTHANTVGDLLETLDIKTRDE DKITPAKQTKITADMDVVYEAAKPVKLTINGEEKTLWSTAKTVGALLDEQDVDVKEQD QIDPAIDTDISKDMKINIEPAFQVTVNDAGKQKKIWTTSTTVADFLKQQKMNIKDEDK IKPALDAKLTKGKADITITRIEKVTDVVEEKIAFDVKKQEDASLEKGKEKVVQKGKEG KLKKHFEVVKENGKEVSRELVKEETAEQSKDKVIAVGTKQSSPKFETVSASGDSKTVV SRSNESTGKVMTVSSTAYTASCSGCSGHTATGVNLKNNPNAKVIAVDPNVIPLGSKVH VEGYGYAIAADTGSAIKGNKIDVFFPEKSSAYRWGNKTVKIKILN*" /label="yabE CDS" gene 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /label="yabE gene" promotor_-35 48240..48247 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 48258 /Source="Nicolas_upshifts" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 48262..48281 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 49494 /Source="Nicolas_upshifts" /id="D17" /incds=0 /nref=87 /ntot=220 /MaxReadThrough="5.02755" /MaxDrop="4.87493" /score="27.529638" /energy="-11.3" /TU="U36,U37,U38" /idTUdmin="U34" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-35 49556..49560 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 49576..49595 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 49578..49677 /Source="Nicolas_S_feature" /locus_tag="new_49987_50086" /HighExp="LoTm, H2O2, G180, G135, G150, Paraq, Oxctl, C30, dia15, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.843, 0.943" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S27" upshifts 49578 /Source="Nicolas_upshifts" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(49602..49617) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(49618) /Source="Nicolas_upshifts" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(49629..49638) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 49674..49690 /Source="Nicolas_upshift_promotors" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /EC_number="3.1.26.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11233981, 11976317, 12794188, 16077031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11233981, 11976317, 12794188, 16077031; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease M5" /protein_id="NP_387922.1" /db_xref="EnsemblGenomes-Gn:BSU00410" /db_xref="EnsemblGenomes-Tr:CAB11817" /db_xref="GOA:P37547" /db_xref="InterPro:IPR004466" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR025156" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG10104" /db_xref="UniProtKB/Swiss-Prot:P37547" /translation="MKIKEIIVVEGRDDTARIKLAVDADTIETNGSAIDDHVIDQIRL AQKTRGVIILTDPDFPGEKIRKTISEAVPGCKHAFLPKHLAKPKNKRGIGVEHASVES IRACLENVHEEMEAQPSDISAEDLIHAGLIGGPAAKCRRERLGDLLKIGYTNGKQLQK RLQMFQIKKSDFMSALDTVMREEQNE*" /label="rnmV CDS" gene 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /label="rnmV gene" upshifts 49688 /Source="Nicolas_upshifts" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" CDS 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 99430, 6801425, 11327780, 1690648, 22391551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dimethyladenosine 16S ribosomal RNA transferase" /protein_id="NP_387923.1" /db_xref="EnsemblGenomes-Gn:BSU00420" /db_xref="EnsemblGenomes-Tr:CAB11818" /db_xref="GOA:P37468" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR011530" /db_xref="InterPro:IPR020596" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023165" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10105" /db_xref="UniProtKB/Swiss-Prot:P37468" /translation="MNKDIATPIRTKEILKKYGFSFKKSLGQNFLIDTNILNRIVDHA EVTEKTGVIEIGPGIGALTEQLAKRAKKVVAFEIDQRLLPILKDTLSPYENVTVIHQD VLKADVKSVIEEQFQDCDEIMVVANLPYYVTTPIIMKLLEEHLPLKGIVVMLQKEVAE RMAADPSSKEYGSLSIAVQFYTEAKTVMIVPKTVFVPQPNVDSAVIRLILRDGPAVDV ENESFFFQLIKASFAQRRKTLLNNLVNNLPEGKAQKSTIEQVLEETNIDGKRRGESLS IEEFAALSNGLYKALF*" /label="rsmA CDS" gene 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /label="rsmA gene" downshifts 51074 /Source="Nicolas_upshifts" /id="D18" /incds=0 /nref=152 /ntot=229 /MaxReadThrough="3.0815" /MaxDrop="4.58632" /score="20.4155562" /energy="-9.4" /TU="NA" /idTUdmin="U36" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 51124..51133 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 51147..51166 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 51149..51270 /Source="Nicolas_S_feature" /locus_tag="new_51558_51679" /HighExp="S7, S6, S8, BT, S5, B36, G/S, Pyr, B60, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S28" upshifts 51149 /Source="Nicolas_upshifts" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="upshifts" CDS 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 11040425, 16751597, 19060142, 19833771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 11040425, 16751597, 19060142, 19833771; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protease" /protein_id="NP_387924.1" /db_xref="EnsemblGenomes-Gn:BSU00430" /db_xref="EnsemblGenomes-Tr:CAB11819" /db_xref="GOA:P37548" /db_xref="InterPro:IPR008764" /db_xref="SubtiList:BG10106" /db_xref="UniProtKB/Swiss-Prot:P37548" /translation="MQFQIGDMVARKSYQMDVLFRIIGIEQTSKGNSIAILHGDEVRL IADSDFSDLVAVKKDEQMMRKKKDESRMNESLELLRQDYKLLREKQEYYATSQYQHQE HYFHMPGKVLHLDGDEAYLKKCLNVYKKIGVPVYGIHCHEKKMSASIEVLLDKYRPDI LVITGHDAYSKQKGGIDDLNAYRHSKHFVETVQTARKKIPHLDQLVIFAGACQSHFES LIRAGANFASSPSRVNIHALDPVYIVAKISFTPFMERINVWEVLRNTLTREKGLGGIE TRGVLRIGMPYKSN*" /label="prtG CDS" gene 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /label="prtG gene" downshifts 52130 /Source="Nicolas_upshifts" /id="D19" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.30424" /MaxDrop="7.1507" /score="26.6672651" /energy="-11.5" /TU="NA" /idTUdmin="U42" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 52240..52310 /Source="Nicolas_S_feature" /locus_tag="new_52649_52719" /HighExp="S8, S5, S7, S6, S4, BT, LoTm, G/S, nit, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S29" promotor_-35 52301..52308 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 52312 /Source="Nicolas_upshifts" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 52322..52341 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(52331..52345) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(52338) /Source="Nicolas_upshifts" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(52354..52358) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12761295, 22720735, 23378512; Producttype ph: phenotype" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387925.1" /db_xref="EnsemblGenomes-Gn:BSU00440" /db_xref="EnsemblGenomes-Tr:CAB11820" /db_xref="GOA:P37466" /db_xref="InterPro:IPR009366" /db_xref="SubtiList:BG10107" /db_xref="UniProtKB/Swiss-Prot:P37466" /translation="MAKTLSDIKRSLDGNLGKRLTLKANGGRRKTIERSGILAETYPS VFVIQLDQDENSFERVSYSYADILTETVELTFNDDAASSVAF*" /label="veg CDS" gene 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /label="veg gene" downshifts 52526 /Source="Nicolas_upshifts" /id="D20" /incds=1 /nref=4 /ntot=158 /MaxReadThrough="8.09861" /MaxDrop="2.7867" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U42" /TUdmin=396 /isTUend="FALSE" /label="downshifts" downshifts 52613 /Source="Nicolas_upshifts" /id="D21" /incds=0 /nref=191 /ntot=264 /MaxReadThrough="5.88511" /MaxDrop="6.03144" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U43" /TUdmin="-331" /isTUend="FALSE" /label="downshifts" promotor_-35 52679..52685 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 52699..52710 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 52702..52773 /Source="Nicolas_S_feature" /locus_tag="new_53111_53182" /HighExp="S8, Cold, S6, S7, ferm, S5, nit, Etha, G135, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S30" upshifts 52702 /Source="Nicolas_upshifts" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="upshifts" CDS 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7959056, 8982008, 11092849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7959056, 8982008, 11092849; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_387926.1" /db_xref="EnsemblGenomes-Gn:BSU00450" /db_xref="EnsemblGenomes-Tr:CAB11821" /db_xref="GOA:P37549" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10108" /db_xref="UniProtKB/Swiss-Prot:P37549" /translation="MGRRRGVMSDEFKYELAKDLGFYDTVKNGGWGEIRARDAGNMVK RAIEIAEQQMAQNQNNR*" /label="sspF CDS" gene 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /label="sspF gene" downshifts 52944 /Source="Nicolas_upshifts" /id="D22" /incds=0 /nref=54 /ntot=153 /MaxReadThrough="2.67408" /MaxDrop="6.21058" /score="38.1065567" /energy="-12.6" /TU="NA" /idTUdmin="U43" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(52954..55308) /Source="Nicolas_S_feature" /locus_tag="new_53363_55717_c" /HighExp="S5, S4, S6, T5.0H, S3, S8, S7, T4.0H, T3.30H, C30" /AntisenseName="ispE" /AntisenseCor="-0.66604185700913698" /AntisenseRegPval="-35.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S31" promotor_-35 53037..53041 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-35" promotor_-10 53057..53076 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-10" upshifts 53060 /Source="Nicolas_upshifts" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="upshifts" CDS 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /EC_number="2.7.1.148" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11361082, 12682299, 12771135, 17458547, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase" /protein_id="NP_387927.1" /db_xref="EnsemblGenomes-Gn:BSU00460" /db_xref="EnsemblGenomes-Tr:CAB11822" /db_xref="GOA:P37550" /db_xref="InterPro:IPR004424" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10109" /db_xref="UniProtKB/Swiss-Prot:P37550" /translation="MRILEKAPAKINLSLDVTRKRPDGYHEVEMIMTTIDLADRIELT ELAEDEVRVSSHNRFVPDDQRNLAYQAAKLIKDRYNVKKGVSIMITKVIPVAAGLAGG SSDAAATLRGLNRLWNLNLSAETLAELGAEIGSDVSFCVYGGTALATGRGEKIKHIST PPHCWVILAKPTIGVSTAEVYRALKLDGIEHPDVQGMIEAIEEKSFQKMCSRLGNVLE SVTLDMHPEVAMIKNQMKRFGADAVLMSGSGPTVFGLVQYESKVQRIYNGLRGFCDQV YAVRMIGEQNALD*" /label="ispE CDS" gene 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /label="ispE gene" CDS 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11591660, 12837783, 12837784, 15629952, 16163456, 27329548" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12837783, 12837784, 15629952, 16163456, 27329548; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine biosynthesis operon (PurR-pRpp)" /protein_id="NP_387928.1" /db_xref="EnsemblGenomes-Gn:BSU00470" /db_xref="EnsemblGenomes-Tr:CAB11823" /db_xref="GOA:P37551" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010078" /db_xref="InterPro:IPR015265" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1O57" /db_xref="PDB:1P4A" /db_xref="SubtiList:BG10110" /db_xref="UniProtKB/Swiss-Prot:P37551" /translation="MKFRRSGRLVDLTNYLLTHPHELIPLTFFSERYESAKSSISEDL TIIKQTFEQQGIGTLLTVPGAAGGVKYIPKMKQAEAEEFVQTLGQSLANPERILPGGY VYLTDILGKPSVLSKVGKLFASVFAEREIDVVMTVATKGIPLAYAAASYLNVPVVIVR KDNKVTEGSTVSINYVSGSSNRIQTMSLAKRSMKTGSNVLIIDDFMKAGGTINGMINL LDEFNANVAGIGVLVEAEGVDERLVDEYMSLLTLSTINMKEKSIEIQNGNFLRFFKDN LLKNGETES*" /label="purR CDS" gene 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /label="purR gene" CDS 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /EC_number="3.5.99.10" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2113912, 12515541, 14729707, 10557275, 10919400, 10368157, 20562306, 23815688; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminoacrylate/iminopropionate hydrolase/deaminase" /protein_id="NP_387929.1" /db_xref="EnsemblGenomes-Gn:BSU00480" /db_xref="EnsemblGenomes-Tr:CAB11824" /db_xref="GOA:P37552" /db_xref="InterPro:IPR006056" /db_xref="InterPro:IPR006175" /db_xref="InterPro:IPR019897" /db_xref="InterPro:IPR035959" /db_xref="PDB:1QD9" /db_xref="SubtiList:BG10111" /db_xref="UniProtKB/Swiss-Prot:P37552" /translation="MTKAVHTKHAPAAIGPYSQGIIVNNMFYSSGQIPLTPSGEMVNG DIKEQTHQVFSNLKAVLEEAGASFETVVKATVFIADMEQFAEVNEVYGQYFDTHKPAR SCVEVARLPKDALVEIEVIALVK*" /label="ridA CDS" gene 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /label="ridA gene" downshifts 55253 /Source="Nicolas_upshifts" /id="D23" /incds=0 /nref=172 /ntot=226 /MaxReadThrough="3.8891" /MaxDrop="4.63425" /score="22.9159767" /energy="-12.3" /TU="U46" /idTUdmin="U46" /TUdmin="-155" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(55297..55315) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 55298..55406 /Source="Nicolas_S_feature" /locus_tag="new_55707_55815" /HighExp="S8, S7, Etha, B36, LoTm, C30, Sw, B60, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S32" upshifts complement(55309) /Source="Nicolas_upshifts" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(55331..55336) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 55386..55394 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-35" promotor_-10 55405..55423 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-10" upshifts 55408 /Source="Nicolas_upshifts" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="upshifts" CDS 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733708, 10348850, 10648512, 16428420, 27048798" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733708, 10348850, 10648512, 16428420, 27048798; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for spore cortex synthesis (stage V sporulation)" /protein_id="NP_387930.1" /db_xref="EnsemblGenomes-Gn:BSU00490" /db_xref="EnsemblGenomes-Tr:CAB11825" /db_xref="GOA:P28015" /db_xref="InterPro:IPR007170" /db_xref="InterPro:IPR036751" /db_xref="PDB:2IA9" /db_xref="SubtiList:BG10112" /db_xref="UniProtKB/Swiss-Prot:P28015" /translation="MEVTDVRLRRVNTDGRMRAIASITLDHEFVVHDIRVIDGNNGLF VAMPSKRTPDGEFRDITHPINSSTRGKIQDAVLNEYHRLGDTEALEFEEAGAS*" /label="spoVG CDS" gene 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /label="spoVG gene" downshifts 55739 /Source="Nicolas_upshifts" /id="D24" /incds=0 /nref=263 /ntot=285 /MaxReadThrough="5.11673" /MaxDrop="7.2673" /score="19.392304" /energy="-22.3" /TU="U48" /idTUdmin="U46" /TUdmin=331 /isTUend="FALSE" /label="downshifts" S_feature 55784..55895 /Source="Nicolas_S_feature" /locus_tag="new_56193_56304" /HighExp="B60, B36, M9-stat, S2, BT, LoTm, Etha, Lbstat, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S33" promotor_-35 55877..55881 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 55897..55916 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 55897 /Source="Nicolas_upshifts" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /EC_number="2.3.1.157" /EC_number="2.7.7.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine pyrophosphorylase" /protein_id="NP_387931.1" /db_xref="EnsemblGenomes-Gn:BSU00500" /db_xref="EnsemblGenomes-Tr:CAB11826" /db_xref="GOA:P14192" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005882" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10113" /db_xref="UniProtKB/Swiss-Prot:P14192" /translation="MDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEALKL SLSKLVTIVGHGAEEVKKQLGDKSEYALQAKQLGTAHAVKQAQPFLADEKGVTIVICG DTPLLTAETMEQMLKEHTQREAKATILTAVAEDPTGYGRIIRSENGAVQKIVEHKDAS EEERLVTEINTGTYCFDNEALFRAIDQVSNDNAQGEYYLPDVIEILKNEGETVAAYQT GNFQETLGVNDRVALSQAEQFMKERINKRHMQNGVTLIDPMNTYISPDAVIGSDTVIY PGTVIKGEVQIGEDTIIGPHTEIMNSAIGSRTVIKQSVVNHSKVGNDVNIGPFAHIRP DSVIGNEVKIGNFVEIKKTQFGDRSKASHLSYVGDAEVGTDVNLGCGSITVNYDGKNK YLTKIEDGAFIGCNSNLVAPVTVGEGAYVAAGSTVTEDVPGKALAIARARQVNKDDYV KNIHKK*" /label="glmU CDS" gene 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /label="glmU gene" downshifts complement(57288) /Source="Nicolas_upshifts" /id="D25" /incds=0 /nref=5 /ntot=84 /MaxReadThrough="2.39379" /MaxDrop="3.65636" /score="-7.65702938" /energy="-13.8" /TU="NA" /idTUdmin="U47" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" CDS 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /EC_number="2.7.6.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2169413, 3038693, 8522540, 22083279, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2169413, 3038693, 8522540, 22083279, 25890046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylpyrophosphate synthetase" /protein_id="NP_387932.1" /db_xref="EnsemblGenomes-Gn:BSU00510" /db_xref="EnsemblGenomes-Tr:CAB11827" /db_xref="GOA:P14193" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR000842" /db_xref="InterPro:IPR005946" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR029099" /db_xref="PDB:1DKR" /db_xref="PDB:1DKU" /db_xref="PDB:1IBS" /db_xref="SubtiList:BG10114" /db_xref="UniProtKB/Swiss-Prot:P14193" /translation="MSNQYGDKNLKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDG EVQINIEESIRGCDCYIIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPYYGYAR QDRKARSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPILGEY FEGKNLEDIVIVSPDHGGVTRARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEGK TAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNSTIKELVVT NSIKLPEEKKIERFKQLSVGPLLAEAIIRVHEQQSVSYLFS*" /label="prs CDS" gene 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /label="prs gene" promotor_-35 58302..58308 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 58321 /Source="Nicolas_upshifts" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 58323..58341 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8522540, 9669336, 10369900, 12432960, 17198710" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8522540, 9669336, 10369900, 12432960, 17198710; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein BL25 (Ctc), binding 5S RNA" /protein_id="NP_387933.1" /db_xref="EnsemblGenomes-Gn:BSU00520" /db_xref="EnsemblGenomes-Tr:CAB11828" /db_xref="GOA:P14194" /db_xref="InterPro:IPR001021" /db_xref="InterPro:IPR011035" /db_xref="InterPro:IPR020056" /db_xref="InterPro:IPR020057" /db_xref="InterPro:IPR029751" /db_xref="InterPro:IPR037121" /db_xref="SubtiList:BG10115" /db_xref="UniProtKB/Swiss-Prot:P14194" /translation="MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDS VELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKNEITHADFQVVNMSEDIEVE VPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPA GGDYSFNHESDEVVASILPPQQQEAAEVDEEESADAQPEGENEQ*" /label="ctc CDS" gene 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /label="ctc gene" downshifts 58972 /Source="Nicolas_upshifts" /id="D26" /incds=0 /nref=120 /ntot=249 /MaxReadThrough="8.65206" /MaxDrop="5.4784" /score="1.94770319" /energy="-11.2" /TU="U49,U50" /idTUdmin="U48" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /EC_number="3.1.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8635758, 12100553, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8635758, 12100553, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-tRNA hydrolase" /protein_id="NP_387934.1" /db_xref="EnsemblGenomes-Gn:BSU00530" /db_xref="EnsemblGenomes-Tr:CAB11829" /db_xref="GOA:P37470" /db_xref="InterPro:IPR001328" /db_xref="InterPro:IPR018171" /db_xref="InterPro:IPR036416" /db_xref="SubtiList:BG10116" /db_xref="UniProtKB/Swiss-Prot:P37470" /translation="MLVIAGLGNPGKNYENTRHNVGFMVIDQLAKEWNIELNQNKFNG LYGTGFVSGKKVLLVKPLTYMNLSGECLRPLMDYYDVDNEDLTVIYDDLDLPTGKIRL RTKGSAGGHNGIKSLIQHLGTSEFDRIRIGIGRPVNGMKVVDYVLGSFTKEEAPEIEE AVDKSVKACEASLSKPFLEVMNEFNAKV*" /label="pth CDS" gene 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /label="pth gene" misc_feature 59274..59277 /Source="Nicolas_upshift_promotors" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 59280 /Source="Nicolas_upshifts" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /experiment="publication(s) with functional evidences, PMID:21037003, 28598017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21037003, 28598017; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein required for the switch from F to G during sporulation (anti sigma F)" /protein_id="NP_387935.1" /db_xref="EnsemblGenomes-Gn:BSU00540" /db_xref="EnsemblGenomes-Tr:CAB11830" /db_xref="GOA:P37553" /db_xref="InterPro:IPR020115" /db_xref="PDB:5MSL" /db_xref="SubtiList:BG10117" /db_xref="UniProtKB/Swiss-Prot:P37553" /translation="MALHYYCRHCGVKVGSLESSMVSTDSLGFQHLTNEERNDMISYK ENGDVHVLTICEDCQEALDRNPHYHEYHTFIQ*" /label="fin CDS" gene 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /label="fin gene" S_feature 59952..60020 /Source="Nicolas_S_feature" /locus_tag="new_60361_60429" /HighExp="Etha, S5, S4, S7, S8, S6, S3, H2O2, Diami, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigB, SigA" /TUshortPSig="0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S34" CDS 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription-repair coupling factor" /protein_id="NP_387936.1" /db_xref="EnsemblGenomes-Gn:BSU00550" /db_xref="EnsemblGenomes-Tr:CAB11831" /db_xref="GOA:P37474" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR004576" /db_xref="InterPro:IPR005118" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG10118" /db_xref="UniProtKB/Swiss-Prot:P37474" /translation="MDNIQTFIKESDDFKSIINGLHEGLKEQLLAGLSGSARSVFTSA LANETNKPIFLITHNLYQAQKVTDDLTSLLEDRSVLLYPVNELISSEIAVASPELRAQ RLDVINRLTNGEAPIVVAPVAAIRRMLPPVEVWKSSQMLIQVGHDIEPDQLASRLVEV GYERSDMVSAPGEFSIRGGIIDIYPLTSENPVRIELFDTEVDSIRSFNSDDQRSIETL TSINIGPAKELIIRPEEKARAMEKIDSGLAASLKKLKADKQKEILHANISHDKERLSE GQTDQELVKYLSYFYEKPASLLDYTPDNTLLILDEVSRIHEMEEQLQKEEAEFITNLL EEGKILHDIRLSFSFQKIVAEQKRPLLYYSLFLRHVHHTSPQNIVNVSGRQMQSFHGQ MNVLAGEMERFKKSNFTVVFLGANKERTQKLSSVLADYDIEAAMTDSKKALVQGQVYI MEGELQSGFELPLMKLAVITEEELFKNRVKKKPRKQKLTNAERIKSYSELQIGDYVVH INHGIGKYLGIETLEINGIHKDYLNIHYQGSDKLYVPVEQIDQVQKYVGSEGKEPKLY KLGGSEWKRVKKKVETSVQDIADDLIKLYAEREASKGYAFSPDHEMQREFESAFPYQE TEDQLRSIHEIKKDMERERPMDRLLCGDVGYGKTEVAIRAAFKAIGDGKQVALLVPTT ILAQQHYETIKERFQDYPINIGLLSRFRTRKEANETIKGLKNGTVDIVIGTHRLLSKD VVYKDLGLLIIDEEQRFGVTHKEKIKQIKANVDVLTLTATPIPRTLHMSMLGVRDLSV IETPPENRFPVQTYVVEYNGALVREAIERELARGGQVYFLYNRVEDIERKADEISMLV PDAKVAYAHGKMTENELETVMLSFLEGESDVLVSTTIIETGVDIPNVNTLIVFDADKM GLSQLYQLRGRVGRSNRVAYAYFTYRRDKVLTEVAEKRLQAIKEFTELGSGFKIAMRD LTIRGAGNLLGAQQHGFIDSVGFDLYSQMLKEAIEERKGDTAKTEQFETEIDVELDAY IPETYIQDGKQKIDMYKRFRSVATIEEKNELQDEMIDRFGNYPKEVEYLFTVAEMKVY ARQERVELIKQDKDAVRLTISEEASAEIDGQKLFELGNQYGRQIGLGMEGKKLKISIQ TKGRSADEWLDTVLGMLKGLKDVKKQTISST*" /label="mfd CDS" gene 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /label="mfd gene" promotor_-35 63572..63578 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 63592..63689 /Source="Nicolas_S_feature" /locus_tag="new_64001_64098" /HighExp="S5, S7, S8, S6, S4, Etha, S3, H2O2, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, Sig-, SigB, SigA" /TUshortPSig="1, 0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S35" promotor_-10 63592..63603 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 63592 /Source="Nicolas_upshifts" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of sporulation / germination" /protein_id="NP_387937.1" /db_xref="EnsemblGenomes-Gn:BSU00560" /db_xref="EnsemblGenomes-Tr:CAB11832" /db_xref="GOA:P37554" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR014213" /db_xref="PDB:2RO5" /db_xref="PDB:2W1R" /db_xref="PDB:2W1T" /db_xref="SubtiList:BG10119" /db_xref="UniProtKB/Swiss-Prot:P37554" /translation="MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEV ILKKYSPISELGDFAKEYADALYDSLGHSVLICDRDVYIAVSGSSKKDYLNKSISEML ERTMDQRSSVLESDAKSVQLVNGIDEDMNSYTVGPIVANGDPIGAVVIFSKDQTMGEV EHKAVETAAGFLARQMEQ*" /label="spoVT CDS" gene 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /label="spoVT gene" downshifts 64230 /Source="Nicolas_upshifts" /id="D27" /incds=0 /nref=236 /ntot=260 /MaxReadThrough="1.92082" /MaxDrop="6.20706" /score="-2.69593259" /energy="-11.6" /TU="NA" /idTUdmin="U49" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 64326..64345 /Source="Nicolas_upshift_promotors" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 64337 /Source="Nicolas_upshifts" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_387938.1" /db_xref="EnsemblGenomes-Gn:BSU00570" /db_xref="EnsemblGenomes-Tr:CAB11833" /db_xref="GOA:P37555" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10120" /db_xref="UniProtKB/Swiss-Prot:P37555" /translation="MDDSIGVKRHWIWQGAFVLILAGVITKILSAVYRVPFQNIVGDV GFYIYQQVYPFLGIAVMLSTSGFPVIISKLMNDYSEKNHHTILKISALFLSLIGILLF LCLYLGAVPIALFMGDSHLAVLIQVAAYAFLLFPFVALLRGGFQGRHEMLPSALSQMT EQFLRVAVLLGLSFWLVKKGASLYTAGAAAASGSLAGSLVALIILGFFWFKTKRDNQT DRQNENVITTKELTKKLLLYSVTICVSSLLLLFIQLVDALNLYALLSGGEASEEAKCL KGIYDRGQPLLQLGSVFAVSIATSLVPYISMAVKNKELKIMKEKITSSLKLCLVLGTG ASAGLICILKPVNIMLFQNGEGTGALQVFSCSILFASLAVTAAAVLQGAGYTVFPAIA VGAGVAVKWVLNTLLVPRYGIEGASLATAASFAAVAGLNLYQLRQKEWLDKLRGVLIP IIGSALLMSAVLLAYTRLWTFLFPATGRGAAVIESLSAVAIGGAVFIYCMMRLGIFTD EELNSVPFGSKLSKFMRRREQNGG*" /label="yabM CDS" gene 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /label="yabM gene" promotor_-35 65877..65884 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-35" promotor_-10 65899..65918 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-10" upshifts 65913 /Source="Nicolas_upshifts" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="upshifts" CDS 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11178267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fusion methylase and nucleotide pyrophosphohydrolase" /protein_id="NP_387939.1" /db_xref="EnsemblGenomes-Gn:BSU00580" /db_xref="EnsemblGenomes-Tr:CAB11834" /db_xref="GOA:P37556" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011551" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR024180" /db_xref="InterPro:IPR035013" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10121" /db_xref="UniProtKB/Swiss-Prot:P37556" /translation="MAGKITVVGLGAGDMDQLTIGIHKLLTKADTLYVRTKDHPLIEE LEKETKNIRFFDDIYEKHDQFEAVYEEIADILFEAARREDVVYAVPGHPFVAEKTVQL LTERQEKENVQVKVAGGQSFLDATFNVLQIDPIEGFQFVDAGTLSADELELRHHLIIC QVYDQMTASEVKLTLMEKLPDDYEVVIVTAAGSRGEEIRTVPLFELDRNVALNNLTSV YIPPIKEEKLLYHEFSTFRSIIRELRGPNGCPWDKKQTHQSLKQYMIEECYELLEAID EEDTDHMIEELGDVLLQVLLHAQIGEDEGYFTIDDVIKGISEKMVRRHPHVFKDVKVQ DENDVLANWEDIKKAEKNTSESSLLDSVPKTLPALSKAAKLQKKAAKVGFDWEDVSDI WEKVSEEMKEFSSEVSEAPHEHNLKAEFGDILFALVNVARFYKIEPEEALTMTNDKFR RRFSYIEETAKEEGVELADMSLEDMDKLWNEAKETERRS*" /label="yabN CDS" gene 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /label="yabN gene" promotor_-35 66637..66644 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-35" promotor_-10 66658..66676 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-10" upshifts 66672 /Source="Nicolas_upshifts" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="upshifts" promotor_no_box complement(67060..67160) /Source="Nicolas_upshift_promotors" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(67100) /Source="Nicolas_upshifts" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10675343, 10675344, 19013177; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal RNA binding protein involved in 50S recycling; heat shock protein" /protein_id="NP_387940.1" /db_xref="EnsemblGenomes-Gn:BSU00590" /db_xref="EnsemblGenomes-Tr:CAB11835" /db_xref="GOA:P37557" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR025490" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10122" /db_xref="UniProtKB/Swiss-Prot:P37557" /translation="MRLDKFLKVSRLIKRRTLAKEVADQGRISINGNQAKASSDVKPG DELTVRFGQKLVTVQVNELKDTTKKEEAANMYTILKEEKLGE*" /label="hslR CDS" gene 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /label="hslR gene" promotor_-35 67733..67738 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 67754..67772 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 67772 /Source="Nicolas_upshifts" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(67804) /Source="Nicolas_upshifts" /id="D28" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="1.93659" /MaxDrop="3.17193" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=3014 /isTUend="FALSE" /label="downshifts" CDS 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15231775, 21904870, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15231775, 21904870, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore protein involved in the shaping of the spore coat" /protein_id="NP_387941.1" /db_xref="EnsemblGenomes-Gn:BSU00600" /db_xref="EnsemblGenomes-Tr:CAB11836" /db_xref="GOA:P37558" /db_xref="InterPro:IPR012504" /db_xref="InterPro:IPR022476" /db_xref="SubtiList:BG10123" /db_xref="UniProtKB/Swiss-Prot:P37558" /translation="MNSYYDQKGSSSVPEQHDVTMKGRKHLDISGVKHVESFDNEEFL LETVMGMLSVRGQNLQMKNLDVEKGIVSIKGRVFDLVYLDEQQGDKAKGFFSKLFK*" /label="spcP CDS" gene 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /label="spcP gene" CDS 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein of the forespore" /protein_id="NP_387942.1" /db_xref="EnsemblGenomes-Gn:BSU00610" /db_xref="EnsemblGenomes-Tr:CAB11837" /db_xref="GOA:P37559" /db_xref="InterPro:IPR014242" /db_xref="InterPro:IPR019074" /db_xref="SubtiList:BG10124" /db_xref="UniProtKB/Swiss-Prot:P37559" /translation="MTLTTQFYTMLAMSGMGLWLGASLDTYRLFVIRAKTARWLLFIH DILFWIMQGLLFFYVLLHVNEGEFRIYIFLAVLLGVATYQSLCKRIYIKILKFVIYLV VSVYQFFKKLIQHVLFRPIVWTCGAIIWLAAFLFKKTYSLIGFLLLCLYKIVMVLCFP IRFIAKQCLKLLPVKMRLTFRRYFEKGAGFLKKKKKLLITIRTTITRFLKR*" /label="spcQ CDS" gene 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /label="spcQ gene" promotor_-35 68611..68620 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68633..68648 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68635 /Source="Nicolas_upshifts" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 68667..68675 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68686..68704 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68696 /Source="Nicolas_upshifts" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_387943.1" /db_xref="EnsemblGenomes-Gn:BSU00620" /db_xref="EnsemblGenomes-Tr:CAB11838" /db_xref="GOA:P37471" /db_xref="InterPro:IPR007060" /db_xref="SubtiList:BG10125" /db_xref="UniProtKB/Swiss-Prot:P37471" /translation="MNFSRERTITEIQNDYKEQVERQNQLKKRRRKGLYRRLTVFGAL VFLTAIVLASSVWSQTSSLSAKEEKKEQLEKELKSLKTKQTDLKEEISKLKDEDYVTE LARRDLFMSGDGEIIFNVEKKSK*" /label="divIC CDS" gene 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /label="divIC gene" CDS 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 15066026, 16014871, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; polyribonucleotide nucleotidyltransferase or phosphorylase" /protein_id="NP_387944.1" /db_xref="EnsemblGenomes-Gn:BSU00630" /db_xref="EnsemblGenomes-Tr:CAB11839" /db_xref="GOA:P37560" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG10126" /db_xref="UniProtKB/Swiss-Prot:P37560" /translation="MSIEVGSKLQGKITGITNFGAFVELPGGSTGLVHISEVADNYVK DINDHLKVGDQVEVKVINVEKDGKIGLSIKKAKDRPQARPRNDFRPKESFEQKMNKFL KDSEDRLSSLKRNTESKRGGRGARRG*" /label="yabR CDS" gene 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /label="yabR gene" downshifts 69597 /Source="Nicolas_upshifts" /id="D29" /incds=0 /nref=247 /ntot=274 /MaxReadThrough="3.67278" /MaxDrop="8.3221" /score="23.2738869" /energy="-12.5" /TU="U58" /idTUdmin="U53" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 69711..69718 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69732..69751 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69747 /Source="Nicolas_upshifts" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="upshifts" tRNA 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="methionine transfer RNA (CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Met1 tRNA" gene 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /label="trnSL-Met1 gene" tRNA 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="glutamate transfer RNA (UUC); Evidence 2a: Functionfrom experimental evidences in other organisms; Producttype n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu1 tRNA" gene 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /label="trnSL-Glu1 gene" downshifts 69928 /Source="Nicolas_upshifts" /id="D30" /incds=0 /nref=2 /ntot=58 /MaxReadThrough="4.83761" /MaxDrop="5.55326" /score="25.2769629" /energy="-10.8" /TU="U58,U60" /idTUdmin="U58" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 69973..70084 /Source="Nicolas_S_feature" /locus_tag="new_70382_70493" /HighExp="Cold, G180, C30, G135, G150, Oxctl, Paraq, H2O2, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S36" misc_feature 70080..70099 /Source="Nicolas_upshift_promotors" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 70086 /Source="Nicolas_upshifts" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="upshifts" CDS 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /EC_number="3.1.3.16" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10747015, 12180929, 15126482, 15866939, 15978076, 28358838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10747015, 12180929, 15126482, 15866939, 15978076, 28358838; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="SpoIIAA-phosphate serine phosphatase" /protein_id="NP_387945.1" /db_xref="EnsemblGenomes-Gn:BSU00640" /db_xref="EnsemblGenomes-Tr:CAB11840" /db_xref="GOA:P37475" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014221" /db_xref="InterPro:IPR036457" /db_xref="PDB:3T91" /db_xref="PDB:3T9Q" /db_xref="PDB:5UCG" /db_xref="SubtiList:BG10127" /db_xref="UniProtKB/Swiss-Prot:P37475" /translation="MEKAERRVNGPMAGQALEKLQSFFNRGTKLVTHHLHSLFFYKGF IYVVIGFLLGRAFILSEVLPFALPFFGAMLLIRRDKAFYAVLAVLAGALTISPKHSLL ILAALLAFFVFSKVAAFITDDRVKALPIVVFFSMAAARAGFVYAQNGVFTTYDYVMAI VEAGLSFILTLIFLQSLPIFTVKKVKQSLKIEEIICFMILIASVLTGLAGLSYQGMQA EHILARYVVLSFSFIGGASIGCTVGVVTGLILGLANIGNLYQMSLLAFSGLLGGLLKE GKKAGAAIGLIVGSLLISLYGEGSAGLMTTLYESLIAVCLFLLTPQSITRKVARYIPG TVEHLQEQQQYARKIRDVTAQKVDQFSNVFHALSESFATFYQASDEQTDDSEVDLFLS KITEHSCQTCYKKNRCWVQNFDKTYDLMKQVMLETEEKEYASNRRLKKEFQQYCSKSK QVEELIEDELAHHHAHLTLKKKVQDSRRLVAEQLLGVSEVMADFSREIKREREQHFLQ EEQIIEALQHFGIEIQHVEIYSLEQGNIDIEMTIPFSGHGESEKIIAPMLSDILEEQI LVKAEQHSPHPNGYSHVAFGSTKSYRVSTGAAHAAKGGGLVSGDSYSMMELGARKYAA AISDGMGNGARAHFESNETIKLLEKILESGIDEKIAIKTINSILSLRTTDEIYSTLDL SIIDLQDASCKFLKVGSTPSFIKRGDQVMKVQASNLPIGIINEFDVEVVSEQLKAGDL LIMMSDGIFEGPKHVENHDLWMKRKMKGLKTNDPQEIADLLMEEVIRTRSGQIEDDMT VVVVRIDHNTPKWASIPVPAIFQNKQEIS*" /label="spoIIE CDS" gene 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /label="spoIIE gene" downshifts 70170 /Source="Nicolas_upshifts" /id="D31" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="5.5737" /MaxDrop="3.93473" /score="25.2769629" /energy="-10.8" /TU="U60,U61" /idTUdmin="U58" /TUdmin=44 /isTUend="FALSE" /label="downshifts" S_feature complement(70781..71390) /Source="Nicolas_S_feature" /locus_tag="new_71190_71799_c" /HighExp="S8, S6, S4, S5, S3, S7, M9-stat, T5.0H, LoTm, Pyr" /AntisenseName="spoIIE" /AntisenseCor="0.685558251745638" /AntisenseRegPval="-38" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S37" downshifts complement(70807) /Source="Nicolas_upshifts" /id="D32" /incds=1 /nref=2 /ntot=11 /MaxReadThrough="2.2425" /MaxDrop="4.29972" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(71363..71381) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(71389) /Source="Nicolas_upshifts" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(71397..71402) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 71594..71600 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 71615..71633 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 71622 /Source="Nicolas_upshifts" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 72632..72635 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 72653..72670 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 72656 /Source="Nicolas_upshifts" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="upshifts" CDS 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387946.1" /db_xref="EnsemblGenomes-Gn:BSU00650" /db_xref="EnsemblGenomes-Tr:CAB11841" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG10128" /db_xref="UniProtKB/Swiss-Prot:P37561" /translation="MNNGHLNQILLITDGCSNHGEDPLAMAAFAKEQGITVNVIGIME ENQIDPEAMKEVEGIALAGGGVHQVVYASQLSQTVQMVTKKAMTQTLQGVVNQELKQI LGKNVEMEELSPEKRGEVMEVVDELGETVHLQVLVLVDTSASMAPKLPTVKEALIDLS VSLNSRIGNNEFAMCIFPGKKQEVELVLNWTPKLQSLSTLFAKLSTGGITPTGPAIRE ATLQFEKIRSRRGMLADDERRFDEFGM*" /label="yabS CDS" gene 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /label="yabS gene" CDS 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23634894, 24731262, 25278935" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23634894, 24731262, 25278935; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine-protein kinase" /protein_id="NP_387947.2" /db_xref="EnsemblGenomes-Gn:BSU00660" /db_xref="EnsemblGenomes-Tr:CAB11842" /db_xref="GOA:P37562" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG10129" /db_xref="UniProtKB/Swiss-Prot:P37562" /translation="MMNDALTSLACSLKPGTTIKGKWNGNTYTLRKQLGKGANGIVYL AETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSF YAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPP ARIRCIDVGGTTKEGRAIKEYTEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKE FKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNGDYQSADEMKKDMLDAGQKAAQRKQ PIKASPQPATRQRQQKPRQGKITKTRYTPKQKPAKSGGLFETTLIVISVLALYFAYII FFLI*" /label="prkT CDS" gene 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /label="prkT gene" promotor_-35 73948..73954 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-35" promotor_-10 73970..73988 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-10" upshifts 73976 /Source="Nicolas_upshifts" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="upshifts" promotor_-35 74446..74453 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 74467..74486 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 74477 /Source="Nicolas_upshifts" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /EC_number="6.3.4.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14527414, 16039592, 17005971, 22720735, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14527414, 16039592, 17005971, 22720735, 24001521; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(ile2) lysidine synthetase" /protein_id="NP_387948.1" /db_xref="EnsemblGenomes-Gn:BSU00670" /db_xref="EnsemblGenomes-Tr:CAB11843" /db_xref="GOA:P37563" /db_xref="InterPro:IPR011063" /db_xref="InterPro:IPR012094" /db_xref="InterPro:IPR012795" /db_xref="InterPro:IPR012796" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015262" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG10130" /db_xref="UniProtKB/Swiss-Prot:P37563" /translation="MKSVKDFLNKHNLTLKGATIIVGVSGGPDSMALLHALHTLCGRS ANVIAAHVDHRFRGAESEEDMRFVQAYCKAEQLVCETAQINVTAYAQEKGLNKQAAAR DCRYQFFEEIMSKHQADYLALAHHGDDQVETMLMKLAKGTLGTGLAGMQPVRRFGTGR IIRPFLTITKEEILHYCHENGLSYRTDESNAKDDYTRNRFRKTVLPFLKQESPDVHKR FQKVSEALTEDEQFLQSLTKDEMNKVITSQSNTSVEINSSQLLALPMPLQRRGVQLIL NYLYENVPSSFSAHHIQQFLDWAENGGPSGVLDFPKGLKVVKSYQTCLFTFEQWQCKN VPFEYQISGAADETAVLPNGYLIEARHYADSPEEHGNAVFITSEKKVRFPLTIRTRKA GDRIKLKGMNGSKKVKDIFIDKKLPLQERDNWPIVTDASGEIIWIPGLKKSIFEDLVI PNSDRIVLQYRQHEKCRGQAKS*" /label="tilS CDS" gene 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /label="tilS gene" promotor_-35 75315..75322 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 75337..75356 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 75340 /Source="Nicolas_upshifts" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" downshifts complement(75933) /Source="Nicolas_upshifts" /id="D33" /incds=0 /nref=2 /ntot=142 /MaxReadThrough="2.51342" /MaxDrop="2.96272" /score="12.3455896" /energy="-9.1" /TU="NA" /idTUdmin="U68" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /EC_number="2.4.2.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3110131, 6408059, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 6408059, 24001521; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hypoxanthine-guanine phosphoribosyltransferase" /protein_id="NP_387949.1" /db_xref="EnsemblGenomes-Gn:BSU00680" /db_xref="EnsemblGenomes-Tr:CAB11844" /db_xref="GOA:P37472" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005904" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10131" /db_xref="UniProtKB/Swiss-Prot:P37472" /translation="MMKHDIEKVLISEEEIQKKVKELGAELTSEYQDTFPLAIGVLKG ALPFMADLIKHIDTYLEMDFMDVSSYGNSTVSSGEVKIIKDLDTSVEGRDILIIEDII DSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADFVGFEVPDAFVVGYGLDY AERYRNLPYIGVLKPAVYES*" /label="hprT CDS" gene 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /label="hprT gene" upshifts complement(76340) /Source="Nicolas_upshifts" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(76342..76346) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(76364..76367) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 76478..76574 /Source="Nicolas_S_feature" /locus_tag="new_76887_76983" /HighExp="Diami, H2O2, dia5, G135, dia15, G150, Paraq, C90, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.999, 1, 0.842" /TUlongSig="SigB, SigA" /TUlongPSig="1, 0.99" /label="S38" CDS 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /EC_number="3.4.24.-" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent cytoplasmic membrane protease" /protein_id="NP_387950.1" /db_xref="EnsemblGenomes-Gn:BSU00690" /db_xref="EnsemblGenomes-Tr:CAB11845" /db_xref="GOA:P37476" /db_xref="InterPro:IPR000642" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR003960" /db_xref="InterPro:IPR005936" /db_xref="InterPro:IPR011546" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR037219" /db_xref="SubtiList:BG10132" /db_xref="UniProtKB/Swiss-Prot:P37476" /translation="MNRVFRNTIFYLLILLVVIGVVSYFQTSNPKTENMSYSTFIKNL DDGKVDSVSVQPVRGVYEVKGQLKNYDKDQYFLTHVPEGKGADQIFNALKKTDVKVEP AQETSGWVTFLTTIIPFVIIFILFFFLLNQAQGGGSRVMNFGKSKAKLYTEEKKRVKF KDVAGADEEKQELVEVVEFLKDPRKFAELGARIPKGVLLVGPPGTGKTLLAKACAGEA GVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCLIFIDEIDAVGRQRGAGLGGG HDEREQTLNQLLVEMDGFSANEGIIIIAATNRADILDPALLRPGRFDRQITVDRPDVI GREAVLKVHARNKPLDETVNLKSIAMRTPGFSGADLENLLNEAALVAARQNKKKIDAR DIDEATDRVIAGPAKKSRVISKKERNIVAYHEGGHTVIGLVLDEADMVHKVTIVPRGQ AGGYAVMLPREDRYFQTKPELLDKIVGLLGGRVAEEIIFGEVSTGAHNDFQRATNIAR RMVTEFGMSEKLGPLQFGQSQGGQVFLGRDFNNEQNYSDQIAYEIDQEIQRIIKECYE RAKQILTENRDKLELIAQTLLKVETLDAEQIKHLIDHGTLPERNFSDDEKNDDVKVNI LTKTEEKKDDTKE*" /label="ftsH CDS" gene 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /label="ftsH gene" downshifts 78486 /Source="Nicolas_upshifts" /id="D34" /incds=0 /nref=187 /ntot=269 /MaxReadThrough="5.00908" /MaxDrop="8.91482" /score="38.4132386" /energy="-12.9" /TU="U66,U67" /idTUdmin="U64" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(78525..78529) /Source="Nicolas_upshift_promotors" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 78531..78616 /Source="Nicolas_S_feature" /locus_tag="new_78940_79025" /HighExp="H2O2, G180, G135, dia15, Paraq, G150, Oxctl, Diami, Cold, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S39" upshifts complement(78533) /Source="Nicolas_upshifts" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 78593..78600 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 78614..78633 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" S_feature 78618..78682 /Source="Nicolas_S_feature" /locus_tag="new_79027_79091" /HighExp="dia5, H2O2, dia15, Paraq, Diami, G180, LBGexp, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S40" upshifts 78618 /Source="Nicolas_upshifts" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15795230, 16905099, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15795230, 16905099, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase type III" /protein_id="NP_387951.2" /db_xref="EnsemblGenomes-Gn:BSU00700" /db_xref="EnsemblGenomes-Tr:CAB11846" /db_xref="GOA:P37564" /db_xref="InterPro:IPR004619" /db_xref="SubtiList:BG10133" /db_xref="UniProtKB/Swiss-Prot:P37564" /translation="MLLVIDVGNTNTVLGVYHDGKLEYHWRIETSRHKTEDEFGMILR SLFDHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFHIEPQIVGPGMKTGLNIKYDN PKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEA LYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVI ATGGLAPLIANESDCIDIVDPFLTLKGLELIYERNRVGSV*" /label="coaX CDS" gene 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /label="coaX gene" CDS 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11323724, 15023991; Product type f: factor" /codon_start=1 /transl_table=11 /product="disulfide bond chaperone (heat shock protein HSP33)" /protein_id="NP_387952.1" /db_xref="EnsemblGenomes-Gn:BSU00710" /db_xref="EnsemblGenomes-Tr:CAB11847" /db_xref="GOA:P37565" /db_xref="InterPro:IPR000397" /db_xref="InterPro:IPR016153" /db_xref="InterPro:IPR016154" /db_xref="PDB:1VZY" /db_xref="SubtiList:BG10134" /db_xref="UniProtKB/Swiss-Prot:P37565" /translation="MDYLVKALAYDGKVRAYAARTTDMVNEGQRRHGTWPTASAALGR TMTASLMLGAMLKGDDKLTVKIEGGGPIGAIVADANAKGEVRAYVSNPQVHFDLNEQG KLDVRRAVGTNGTLSVVKDLGLREFFTGQVEIVSGELGDDFTYYLVSSEQVPSSVGVG VLVNPDNTILAAGGFIIQLMPGTDDETITKIEQRLSQVEPISKLIQKGLTPEEILEEV LGEKPEILETMPVRFHCPCSKERFETAILGLGKKEIQDMIEEDGQAEAVCHFCNEKYL FTKEELEGLRDQTTR*" /label="hslO CDS" gene 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /label="hslO gene" CDS 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 15856219; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein chaperone accessory lipoproteinfactor" /protein_id="NP_387953.1" /db_xref="EnsemblGenomes-Gn:BSU00720" /db_xref="EnsemblGenomes-Tr:CAB11848" /db_xref="GOA:P37566" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR027304" /db_xref="SubtiList:BG10135" /db_xref="UniProtKB/Swiss-Prot:P37566" /translation="MKSRTIWTIILGALLVCCIAVAYTLTKSQAGASSSGESIATIGG KSVTREEWLKEMEDQYGKSTLEDMINVRVVEQLAKKNKLKISKSEVDREFLLIKAVNN SFYEDEHTTEKEWKDQIRYNILLEDLLTRDIDISNKELESFYNKNKELYQFDDSYRIR HIVVKDEEEAREVLKELKGGSSFEAVAAERSTDRYTSPYGGDLGFVTEASDNIPSAYI EEAKTLKEDEWSQEPIKVSNGYAIIQLKEKLKARTFSFDEVKDQIRRQIAMDQLGDKA TVKTLWKEADVSWFYGEKSTK*" /label="yacD CDS" gene 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /label="yacD gene" promotor_-35 81016..81021 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 81038..81056 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 81039 /Source="Nicolas_upshifts" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 81285..81292 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 81307..81326 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 81314 /Source="Nicolas_upshifts" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /EC_number="2.5.1.47" /EC_number="4.4.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 15760717, 16267287, 16513748, 17056751, 18974048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15760717, 16267287, 16513748, 17056751, 18974048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cysteine synthase" /protein_id="NP_387954.1" /db_xref="EnsemblGenomes-Gn:BSU00730" /db_xref="EnsemblGenomes-Tr:CAB11849" /db_xref="GOA:P37887" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10136" /db_xref="UniProtKB/Swiss-Prot:P37887" /translation="MVRVANSITELIGNTPIVKLNRLADENSADVYLKLEYMNPGSSV KDRIGLAMIEAAEKEGKLKAGNTIIEPTSGNTGIGLAMVAAAKGLKAILVMPDTMSME RRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHGYFVPQQFNNPSNPEIHRQTTGK EIVEQFGDDQLDAFVAGIGTGGTITGAGEVLKEAYPSIKIYAVEPSDSPVLSGGKPGP HKIQGIGAGFVPDILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISSGAAIYAAL QVAKKLGKGKKVLAIIPSNGERYLSTPLYQFD*" /label="cysK CDS" gene 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /label="cysK gene" downshifts 82281 /Source="Nicolas_upshifts" /id="D35" /incds=0 /nref=156 /ntot=259 /MaxReadThrough="5.90023" /MaxDrop="5.38596" /score="41.7897705" /energy="-11.4" /TU="U72" /idTUdmin="U70" /TUdmin=10 /isTUend="TRUE" /label="downshifts" promotor_-35 82335..82343 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 82357..82365 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 82359 /Source="Nicolas_upshifts" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 82387..82390 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 82405..82424 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 82415 /Source="Nicolas_upshifts" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /EC_number="2.6.1.85" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 9084182, 16605270, 17114263, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase (para-aminobenzoate synthase)" /protein_id="NP_387955.1" /db_xref="EnsemblGenomes-Gn:BSU00740" /db_xref="EnsemblGenomes-Tr:CAB11850" /db_xref="GOA:P28820" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10137" /db_xref="UniProtKB/Swiss-Prot:P28820" /translation="MAQRRPAGKKIPFQKDSFLQQFEKLAQSRKHHVLLESARGGRYS IAGLDPIATVKGKDGITTIKHGDEMLFKEGDPLRAFHSWFKTLETETNHEFPDFQGGA IGFLSYDYARYIENFKMLSLDDLETPDIYFLVFDDIAVYDHQEESLWLITHVNGSDQE TADVKLSELEQMWLTELPAVTSREMKPETAGSFAAPFTEDGFSQAVEKIKQYIASGDV FQVNLSIRQSQSLSVHPYQIYKTLREVNPSPYMAYLETPDFQIICGSPELLVSKKGKL LETRPIAGTRSRGKTNEEDEALANELIHNEKERAEHVMLVDLERNDLGRVSRYGSVRV NEFMAIEKYSHVMHIVSNVQGELQDGYDAVDIIHAVFPGGTITGAPKVRTMEIIEELE PTRRGLYTGSIGWFGYNHDLQFNIVIRTIYATGGQAFMQSGAGVVIDSVPKHEYKESF KKAFAMQRALELSEEETKIR*" /label="pabB CDS" gene 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /label="pabB gene" promotor_-35 83257..83259 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 83277..83295 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 83283 /Source="Nicolas_upshifts" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 83624..83631 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 83644..83663 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 83657 /Source="Nicolas_upshifts" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /EC_number="2.6.1.85" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098056, 16605270, 17114263, 24847778; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase; anthranilatesynthase (subunit II)" /protein_id="NP_387956.1" /db_xref="EnsemblGenomes-Gn:BSU00750" /db_xref="EnsemblGenomes-Tr:CAB11851" /db_xref="GOA:P28819" /db_xref="InterPro:IPR006221" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10138" /db_xref="UniProtKB/Swiss-Prot:P28819" /translation="MILMIDNYDSFTYNLVQYLGELGEELVVKRNDSITIDEIEELSP DFLMISPGPCSPDEAGISLEAIKHFAGKIPIFGVCLGHQSIAQVFGGDVVRAERLMHG KTSDIEHDGKTIFEGLKNPLVATRYHSLIVKPETLPSCFTVTAQTKEGEIMAIRHNDL PIEGVQFHPESIMTSFGKEMLRNFIETYRKEVIA*" /label="pabA CDS" gene 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /label="pabA gene" CDS 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /EC_number="4.1.3.38" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10876155, 1644759, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate pyruvate-lyase" /protein_id="NP_387957.1" /db_xref="EnsemblGenomes-Gn:BSU00760" /db_xref="EnsemblGenomes-Tr:CAB11852" /db_xref="GOA:P28821" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR017824" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10139" /db_xref="UniProtKB/Swiss-Prot:P28821" /translation="MIYVNGRYMEEKDAVLSPFDHGFLYGIGVFETFRLYEGCPFLLD WHIERLERALKDLQIEYTVSKHEILEMLDKLLKLNDIKDGNARVRLNISAGISDKGFV AQTYDKPTVLCFVNQLKPESLPLQKEGKVLSIRRNTPEGSFRLKSHHYLNNMYAKREI GNDPRVEGIFLTEDGAVAEGIISNVFWRKGRCIYTPSLDTGILDGVTRRFIIENAKDI GLELKTGRYELEALLTADEAWMTNSVLEIIPFTKIEEVNYGSQSGEATSALQLLYKKE IKNMIHEKGGRAWRSTQ*" /label="pabC CDS" gene 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /label="pabC gene" CDS 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /EC_number="2.5.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 11007651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydropteroate synthase" /protein_id="NP_387958.1" /db_xref="EnsemblGenomes-Gn:BSU00770" /db_xref="EnsemblGenomes-Tr:CAB11853" /db_xref="GOA:P28822" /db_xref="InterPro:IPR000489" /db_xref="InterPro:IPR006390" /db_xref="InterPro:IPR011005" /db_xref="SubtiList:BG10140" /db_xref="UniProtKB/Swiss-Prot:P28822" /translation="MAQHTIDQTQVIHTKPSALSYKEKTLVMGILNVTPDSFSDGGKY DSLDKALLHAKEMIDDGAHIIDIGGESTRPGAECVSEDEEMSRVIPVIERITKELGVP ISVDTYKASVADEAVKAGASIINDIWGAKHDPKMASVAAEHNVPIVLMHNRPERNYND LLPDMLSDLMESVKIAVEAGVDEKNIILDPGIGFAKTYHDNLAVMNKLEIFSGLGYPV LLATSRKRFIGRVLDLPPEERAEGTGATVCLGIQKGCDIVRVHDVKQIARMAKMMDAM LNKGGVHHG*" /label="folP CDS" gene 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /label="folP gene" CDS 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /EC_number="4.1.2.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16188473, 17176045, 17388809; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroneopterin aldolase" /protein_id="NP_387959.1" /db_xref="EnsemblGenomes-Gn:BSU00780" /db_xref="EnsemblGenomes-Tr:CAB11854" /db_xref="GOA:P28823" /db_xref="InterPro:IPR006156" /db_xref="InterPro:IPR006157" /db_xref="SubtiList:BG10141" /db_xref="UniProtKB/Swiss-Prot:P28823" /translation="MDKVYVEGMEFYGYHGVFTEENKLGQRFKVDLTAELDLSKAGQT DDLEQTINYAELYHVCKDIVEGEPVKLVETLAERIAGTVLGKFQPVQQCTVKVIKPDP PIPGHYKSVAIEITRKKS*" /label="folB CDS" gene 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /label="folB gene" CDS 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /EC_number="2.7.6.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17029412; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase" /protein_id="NP_387960.1" /db_xref="EnsemblGenomes-Gn:BSU00790" /db_xref="EnsemblGenomes-Tr:CAB11855" /db_xref="GOA:P29252" /db_xref="InterPro:IPR000550" /db_xref="InterPro:IPR035907" /db_xref="SubtiList:BG10142" /db_xref="UniProtKB/Swiss-Prot:P29252" /translation="MNNIAYIALGSNIGDRETYLRQAVALLHQHAAVTVTKVSSIYET DPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGRTREVRWGPRTADLDILLF NRENIETEQLIVPHPRMYERLFVLAPLAEICQQVEKEATSAETDQEGVRVWKQKSGVD EFVHSES*" /label="folK CDS" gene 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /label="folK gene" CDS 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_387961.1" /db_xref="EnsemblGenomes-Gn:BSU00800" /db_xref="EnsemblGenomes-Tr:CAB11856" /db_xref="GOA:O31417" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG12701" /db_xref="UniProtKB/Swiss-Prot:O31417" /translation="MEAEIWGRRIRAFRKLKGYTQEGFAKALGISVSILGEIERGNRL PSAAIIQDAADVLNISADELAPPEK*" /label="yazB CDS" gene 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /label="yazB gene" CDS 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 15698474, 26112661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase B" /protein_id="NP_387962.1" /db_xref="EnsemblGenomes-Gn:BSU00810" /db_xref="EnsemblGenomes-Tr:CAB11857" /db_xref="GOA:P37567" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR004652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG10143" /db_xref="UniProtKB/Swiss-Prot:P37567" /translation="MFKIGDIQLKNRVVLAPMAGVCNSAFRLTVKEFGAGLVCAEMVS DKAILYNNARTMGMLYIDEREKPLSLQIFGGKKETLVEAAKFVDQNTTADIIDINMGC PVPKITKCDAGAKWLLDPDKIYEMVSAVVDAVNKPVTVKMRMGWDEDHIFAVKNAQAV ERAGGKAVALHGRTRVQMYEGTANWDIIKEVKQSVSIPVIGNGDVKTPQDAKRMLDET GVDGVMIGRAALGNPWMIYRTVQYLETGKLKEEPQVREKMAVCKLHLDRLIDLKGENV AVREMRKHAAWYLKGVKGNANVRNEINHCETREEFVQLLDAFTVEVEAKELQNAKVG* " /label="dusB CDS" gene 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /label="dusB gene" S_feature complement(87641..89157) /Source="Nicolas_S_feature" /locus_tag="new_88050_89566_c" /HighExp="LoTm, C30, S6, S8, S5, S7, S3, S4, C90, G135" /AntisenseName="dusB" /AntisenseCor="-0.60218706634778196" /AntisenseRegPval="-27.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S41" S_feature 88227..88317 /Source="Nicolas_S_feature" /locus_tag="new_88636_88726" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, Diami, C30, LBGexp, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="SigA, SigI, SigA, SigEF, SigA, SigA, SigA" /TUlongPSig="0.621, 0.787, 1, 0.995, 1, 0.999, 1" /label="S42" CDS 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /EC_number="6.1.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14623972, 20649968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14623972, 20649968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lysyl-tRNA synthetase" /protein_id="NP_387963.1" /db_xref="EnsemblGenomes-Gn:BSU00820" /db_xref="EnsemblGenomes-Tr:CAB11858" /db_xref="GOA:P37477" /db_xref="InterPro:IPR002313" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018149" /db_xref="InterPro:IPR034762" /db_xref="SubtiList:BG10144" /db_xref="UniProtKB/Swiss-Prot:P37477" /translation="MSQEEHNHEELNDQLQVRRDKMNQLRDNGIDPFGARFERTHQSQ EVISAYQDLTKEELEEKAIEVTIAGRMMTKRGKGKAGFAHLQDLEGQIQIYVRKDSVG DDQYEIFKSSDLGDLIGVTGKVFKTNVGELSVKATSFELLTKALRPLPDKYHGLKDVE QRYRQRYLDLIVNPDSKHTFITRSKIIQAMRRYLDDHGYLEVETPTMHSIPGGASARP FITHHNALDIPLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIEL YEAYADYKDIMSLTENLVAHIAQEVLGTTTIQYGEEQIDLKPEWKRIHMVDAVKEATG VDFWEEVTVEQAREYAKEHEVEIKDSMTVGHIINEFFEQKIEETLIQPTFIYGHPVEI SPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQRERFEAQLKEREAGNDEAH LMDEDFVEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPQMRQR*" /label="lysS CDS" gene 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /label="lysS gene" promotor_-10 complement(89141..89159) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(89157) /Source="Nicolas_upshifts" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(89175..89180) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 89798 /Source="Nicolas_upshifts" /id="D36" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="4.49559" /MaxDrop="4.89484" /score="4.33485487" /energy="-18.1" /TU="U76" /idTUdmin="U74" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 89893..89900 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 89909..90126 /Source="Nicolas_S_feature" /locus_tag="new_90318_90535" /HighExp="LBGstat, H2O2, Oxctl, Diami, dia15, Paraq, MG 25, Heat, MG 15, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 0.998, 1, 1, 0.999, 1" /label="S43" upshifts 89909 /Source="Nicolas_upshifts" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 89914..89933 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(89959) /Source="Nicolas_upshifts" /id="D37" /incds=0 /nref=3 /ntot=51 /MaxReadThrough="3.16217" /MaxDrop="5.0092" /score="18.6635354" /energy="-16.9" /TU="NA" /idTUdmin="U77" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" rRNA 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-16S rRNA" gene 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /label="rrnJ-16S gene" rRNA 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-23S rRNA" gene 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /label="rrnJ-23S gene" rRNA 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-5S rRNA" gene 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /label="rrnJ-5S gene" tRNA 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Val tRNA" gene 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /label="trnJ-Val gene" tRNA 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Thr tRNA" gene 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /label="trnJ-Thr gene" tRNA 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Lys tRNA" gene 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /label="trnJ-Lys gene" tRNA 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu1 tRNA" gene 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /label="trnJ-Leu1 gene" tRNA 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Gly tRNA" gene 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /label="trnJ-Gly gene" tRNA 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu2 tRNA" gene 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /label="trnJ-Leu2 gene" tRNA 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA(ACG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Arg tRNA" gene 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /label="trnJ-Arg gene" tRNA 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Pro(UGG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Pro tRNA" gene 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /label="trnJ-Pro gene" tRNA 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Ala tRNA" gene 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /label="trnJ-Ala gene" rRNA 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-16S rRNA" gene 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /label="rrnW-16S gene" rRNA 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-23S rRNA" gene 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /label="rrnW-23S gene" rRNA 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-5S rRNA" gene 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /label="rrnW-5S gene" S_feature 100803..100880 /Source="Nicolas_S_feature" /locus_tag="new_101212_101289" /HighExp="G135, G180, G150, Cold, Paraq, Oxctl, H2O2, C30, BMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S44" promotor_-35 100850..100853 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100869..100888 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100882 /Source="Nicolas_upshifts" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-35 100916..100922 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-35" promotor_-10 100936..100955 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-10" upshifts 100947 /Source="Nicolas_upshifts" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="upshifts" promotor_-35 100962..100969 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100983..101002 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100995 /Source="Nicolas_upshifts" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of class III stress genes" /protein_id="NP_387964.1" /db_xref="EnsemblGenomes-Gn:BSU00830" /db_xref="EnsemblGenomes-Tr:CAB11859" /db_xref="GOA:P37568" /db_xref="InterPro:IPR008463" /db_xref="SubtiList:BG10145" /db_xref="UniProtKB/Swiss-Prot:P37568" /translation="MGHNISDIIEQYLKRVLDQNGKEILEIKRSEIADKFQCVPSQIN YVINTRFTSERGYIVESKRGGGGYIRIIKIKMNNEVVLINNIISQINTHLSQAASDDI ILRLLEDKVISEREAKMMVSVMDRSVLHIDLPERDELRARMMKAMLTSLKLK*" /label="ctsR CDS" gene 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /label="ctsR gene" misc_feature complement(101151..101155) /Source="Nicolas_upshift_promotors" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(101157) /Source="Nicolas_upshifts" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 19189946, 24947607" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 19189946, 24947607; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of protein kinase McsB" /protein_id="NP_387965.1" /db_xref="EnsemblGenomes-Gn:BSU00840" /db_xref="EnsemblGenomes-Tr:CAB11860" /db_xref="GOA:P37569" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR025542" /db_xref="InterPro:IPR029037" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10146" /db_xref="UniProtKB/Swiss-Prot:P37569" /translation="MICQECHERPATFHFTKVVNGEKIEVHICEQCAKENSDSYGISA NQGFSIHNLLSGLLNMDSSFQNAGTQMFSHSEQISACPKCGMTFQQFRKIGRFGCSEC YKTFHSNITPILRKVHSGNTVHAGKIPKRIGGNLHVRRQIDMLKKELESLIHQEEFEN AAHVRDQIRLLEQSLKSTDSEEEQE*" /label="mcsA CDS" gene 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /label="mcsA gene" CDS 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /EC_number="2.7.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 17380125, 19189946, 21622759, 25610436, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 17380125, 19189946, 21622759, 25610436, 27749819; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein arginine kinase" /protein_id="NP_387966.1" /db_xref="EnsemblGenomes-Gn:BSU00850" /db_xref="EnsemblGenomes-Tr:CAB11861" /db_xref="GOA:P37570" /db_xref="InterPro:IPR000749" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR022414" /db_xref="InterPro:IPR022415" /db_xref="InterPro:IPR023660" /db_xref="SubtiList:BG10147" /db_xref="UniProtKB/Swiss-Prot:P37570" /translation="MSLKHFIQDALSSWMKQKGPESDIVLSSRIRLARNFEHIRFPTR YSNEEASSIIQQFEDQFSEQEIPGIGKFVLIRMNDAQPLEKRVLVEKHLISPNLTESP FGGCLLSENEEVSVMLNEEDHIRIQCLFPGFQLLEAMKAANQVDDWIEEKVDYAFNEQ RGYLTSCPTNVGTGLRASVMMHLPALVLTRQINRIIPAINQLGLVVRGIYGEGSEAVG NIFQISNQITLGKSEQDIVEDLNSVAAQLIEQERSAREAIYQTSKIELEDRVYRSYGV LSNCRMIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALRP NERDIRRAALIRERLHLEMNGKRQEDESI*" /label="mcsB CDS" gene 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /label="mcsB gene" CDS 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354604, 15529410, 16525504, 26735940, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354604, 15529410, 16525504, 26735940, 27749819; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III stress response-related ATPase, AAA+ superfamily" /protein_id="NP_387967.1" /db_xref="EnsemblGenomes-Gn:BSU00860" /db_xref="EnsemblGenomes-Tr:CAB11862" /db_xref="GOA:P37571" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004176" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="InterPro:IPR036628" /db_xref="PDB:2K77" /db_xref="PDB:2Y1Q" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="PDB:5HBN" /db_xref="SubtiList:BG10148" /db_xref="UniProtKB/Swiss-Prot:P37571" /translation="MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEG IAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHYTPRAKKVIELSMDEARKLGHSY VGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIA EGLAQQIINNEVPEILRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIIL FIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRF QPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAI DLIDEAGSKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLR EQVEDTKKSWKEKQGQENSEVTVDDIAMVVSSWTGVPVSKIAQTETDKLLNMENILHS RVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESIFGDE ESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHP DVFNILLQVLEDGRLTDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNH KDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLTEIVSLMSDQLTKRLKEQDLS IELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVED GEFVVKTTAKTN*" /label="clpC CDS" gene 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /label="clpC gene" downshifts 105590 /Source="Nicolas_upshifts" /id="D38" /incds=0 /nref=57 /ntot=245 /MaxReadThrough="6.69446" /MaxDrop="4.4703" /score="-8.32149463" /energy="-11.7" /TU="U80,U81" /idTUdmin="U79" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /EC_number="2.1.1.63" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931349, 11810266, 15317759, 25616256; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair protein; 6-O-methylguanine-DNA methyltransferase" /protein_id="NP_387968.1" /db_xref="EnsemblGenomes-Gn:BSU00870" /db_xref="EnsemblGenomes-Tr:CAB11863" /db_xref="GOA:P37572" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004504" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10149" /db_xref="UniProtKB/Swiss-Prot:P37572" /translation="MAKTKSKFICQSCGYESPKWMGKCPGCGAWNTMVEEMIKKAPAN RRAAFSHSVQTVQKPSPITSIETSEEPRVKTQLGEFNRVLGGGVVKGSLVLIGGDPGI GKSTLLLQVSAQLSGSSNSVLYISGEESVKQTKLRADRLGINNPSLHVLSETDMEYIS SAIQEMNPSFVVVDSIQTVYQSDITSAPGSVSQVRECTAELMKIAKTKGIPIFIVGHV TKEGSIAGPRLLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEMGIFEMREEGLTE VLNPSEIFLEERSAGSAGSSITASMEGTRPILVEIQALISPTSFGNPRRMATGIDHNR VSLLMAVLEKRVGLLLQNQDAYLKVAGGVKLDEPAIDLAIVISIASSFRDTPPNPADC FIGEVGLTGEVRRVSRIEQRVKEAAKLGFKRMIIPAANLDGWTKPKGIEVIGVANVAE ALRTSLGG*" /label="radA CDS" gene 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /label="radA gene" promotor_-35 106142..106151 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 106164..106179 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 106167 /Source="Nicolas_upshifts" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase; DNA integrity scanning protein; cell cycle checkpoint DNA scanning protein" /protein_id="NP_387969.1" /db_xref="EnsemblGenomes-Gn:BSU00880" /db_xref="EnsemblGenomes-Tr:CAB11864" /db_xref="GOA:P37573" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR018906" /db_xref="InterPro:IPR023763" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG10150" /db_xref="UniProtKB/Swiss-Prot:P37573" /translation="MEKEKKGAKHELDLSSILQFVAPGTPLRAGMENVLRANTGGLIV VGYNDKVKEVVDGGFHINTAFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPDATI SSSETGMRHRTAERVAKQTGCLVIAISERRNVITLYQENMKYTLKDIGFILTKANQAI QTLEKYKTILDKTINALNALEFEELVTFSDVLSVMHRYEMVLRIKNEINMYIKELGTE GHLIKLQVIELITDMEEEAALFIKDYVKEKIKDPFVLLKELQDMSSYDLLDDSIVYKL LGYPASTNLDDYVLPRGYRLLNKIPRLPMPIVENVVEAFGVLPRIIEASAEELDEVEG IGEVRAQKIKKGLKRLQEKHYLDRQL*" /label="disA CDS" gene 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /label="disA gene" S_feature 108150..108264 /Source="Nicolas_S_feature" /locus_tag="new_108559_108673" /HighExp="Etha, Salt, Heat, dia15, Diami, M9-stat, B60, T-0.40H, T-1.10H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.947" /label="S45" CDS 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26999498; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein possibly involved in RNA binding" /protein_id="NP_387970.1" /db_xref="EnsemblGenomes-Gn:BSU00890" /db_xref="EnsemblGenomes-Tr:CAB11865" /db_xref="GOA:Q06754" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG10151" /db_xref="UniProtKB/Swiss-Prot:Q06754" /translation="MLKRIVQAFFIIFGGVVGIFLIPELFVLLNIQDIPLITNAYTSA AIGAIIFFLISIWGTEYVVNWVKWIEDSLLKAPVPDLLFGSLGLVFGLIIAYLIVNVI PLDNIPYRIFSTIIPVFLAFFLGYLGFQVGFKKKDELISLFSISARMQKKKGTADEEH EVQDKKLKILDTSVIIDGRIADICQTGFLEGVIVIPQFVLEELQHIADSSDVLKRNRG RRGLDILNRIQKELDIEVEIYEGDFEDIQEVDSKLVKLAKLTSGVVVTNDFNLNKVCE LQKVAVLNINDLANAVKPVVLPGEEMNVQVIKDGKEHNQGVAYLDDGTMIVVEEGRNY IGKHIDVLVTSVLQTAAGRMIFAKPKLLEKAL*" /label="yacL CDS" gene 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /label="yacL gene" downshifts complement(109187) /Source="Nicolas_upshifts" /id="D39" /incds=1 /nref=1 /ntot=103 /MaxReadThrough="0.39171" /MaxDrop="2.87304" /score="-9.71423487" /energy="-11.8" /TU="NA" /idTUdmin="U82" /TUdmin="-8228" /isTUend="FALSE" /label="downshifts" CDS 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /EC_number="2.7.7.60" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, nonmevalonate isoprenoid pathway" /protein_id="NP_387971.1" /db_xref="EnsemblGenomes-Gn:BSU00900" /db_xref="EnsemblGenomes-Tr:CAB11866" /db_xref="GOA:Q06755" /db_xref="InterPro:IPR001228" /db_xref="InterPro:IPR018294" /db_xref="InterPro:IPR029044" /db_xref="InterPro:IPR034683" /db_xref="PDB:5DDT" /db_xref="PDB:5DDV" /db_xref="PDB:5HS2" /db_xref="SubtiList:BG10152" /db_xref="UniProtKB/Swiss-Prot:Q06755" /translation="MSYDVVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHR QCDKIILVINEQEREHFQQLLSDYPFQTSIELVAGGDERQHSVYKGLKAVKQEKIVLV HDGARPFIKHEQIDELIAEAEQTGAAILAVPVKDTIKRVQDLQVSETIERSSLWAVQT PQAFRLSLLMKAHAEAERKGFLGTDDASLVEQMEGGSVRVVEGSYTNIKLTTPDDLTS AEAIMESESGNKHV*" /label="ispD CDS" gene 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /label="ispD gene" CDS 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /EC_number="4.6.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9622350, 11997478, 12270818, 12682299, 17458547, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 11997478, 12270818, 12682299, 17458547, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase" /protein_id="NP_387972.1" /db_xref="EnsemblGenomes-Gn:BSU00910" /db_xref="EnsemblGenomes-Tr:CAB11867" /db_xref="GOA:Q06756" /db_xref="InterPro:IPR003526" /db_xref="InterPro:IPR020555" /db_xref="InterPro:IPR036571" /db_xref="PDB:5IWX" /db_xref="PDB:5IWY" /db_xref="SubtiList:BG10153" /db_xref="UniProtKB/Swiss-Prot:Q06756" /translation="MFRIGQGFDVHQLVEGRPLIIGGIEIPYEKGLLGHSDADVLLHT VADACLGAVGEGDIGKHFPDTDPEFKDADSFKLLQHVWGIVKQKGYVLGNIDCTIIAQ KPKMLPYIEDMRKRIAEGLEADVSQVNVKATTTEKLGFTGRAEGIAAQATVLIQKG*" /label="ispF CDS" gene 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /label="ispF gene" promotor_-35 110551..110558 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 110572..110591 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 110585 /Source="Nicolas_upshifts" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /EC_number="6.1.1.24" /EC_number="6.1.1.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA synthetase" /protein_id="NP_387973.1" /db_xref="EnsemblGenomes-Gn:BSU00920" /db_xref="EnsemblGenomes-Tr:CAB11868" /db_xref="GOA:P22250" /db_xref="InterPro:IPR000924" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR004527" /db_xref="InterPro:IPR008925" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020058" /db_xref="InterPro:IPR020061" /db_xref="InterPro:IPR020751" /db_xref="InterPro:IPR020752" /db_xref="InterPro:IPR033910" /db_xref="SubtiList:BG10154" /db_xref="UniProtKB/Swiss-Prot:P22250" /translation="MGNEVRVRYAPSPTGHLHIGNARTALFNYLFARNQGGKFIIRVE DTDKKRNIEGGEQSQLNYLKWLGIDWDESVDVGGEYGPYRQSERNDIYKVYYEELLEK GLAYKCYCTEEELEKEREEQIARGEMPRYSGKHRDLTQEEQEKFIAEGRKPSIRFRVP EGKVIAFNDIVKGEISFESDGIGDFVIVKKDGTPTYNFAVAIDDYLMKMTHVLRGEDH ISNTPKQIMIYQAFGWDIPQFGHMTLIVNESRKKLSKRDESIIQFIEQYKELGYLPEA LFNFIGLLGWSPVGEEELFTKEQFIEIFDVNRLSKSPALFDMHKLKWVNNQYVKKLDL DQVVELTLPHLQKAGKVGTELSAEEQEWVRKLISLYHEQLSYGAEIVELTDLFFTDEI EYNQEAKAVLEEEQVPEVLSTFAAKLEELEEFTPDNIKASIKAVQKETGHKGKKLFMP IRVAVTGQTHGPELPQSIELIGKETAIQRLKNI*" /label="gltX CDS" gene 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /label="gltX gene" promotor_-35 111567..111576 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-35" promotor_-10 111590..111609 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-10" upshifts 111590 /Source="Nicolas_upshifts" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="upshifts" S_feature 112090..112390 /Source="Nicolas_S_feature" /locus_tag="new_112499_112799" /HighExp="S6, S8, S7, Diami, C90, LBGexp, G135, H2O2, dia5, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17844199999999999" /TUshortSig="SigK, SigA, SigWXY" /TUshortPSig="1, 0.999, 1" /TUlongSig="SigA, SigB, SigA" /TUlongPSig="1, 1, 0.947" /label="S46" CDS 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /EC_number="2.3.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7510287, 10737181, 10939241, 17056751, 18974048, 25731080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7510287, 10737181, 10939241, 17056751, 18974048, 25731080; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine O-acetyltransferase" /protein_id="NP_387974.1" /db_xref="EnsemblGenomes-Gn:BSU00930" /db_xref="EnsemblGenomes-Tr:CAB11869" /db_xref="GOA:Q06750" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005881" /db_xref="InterPro:IPR010493" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="SubtiList:BG10155" /db_xref="UniProtKB/Swiss-Prot:Q06750" /translation="MFFRMLKEDIDTVFDQDPAARSYFEVILTYSGLHAIWAHRIAHA LYKRKFYFLARLISQVSRFFTGIEIHPGATIGRRFFIDHGMGVVIGETCEIGNNVTVF QGVTLGGTGKEKGKRHPTIKDDALIATGAKVLGSITVGEGSKIGAGSVVLHDVPDFST VVGIPGRVVVQNGKKVRRDLNHQDLPDPVADRFKSLEQQILELKAELEDRKERINQK* " /label="cysE CDS" gene 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /label="cysE gene" CDS 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /EC_number="6.1.1.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10024179, 10546897, 10931887, 12682299, 29079736" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024179, 10546897, 10931887, 12682299, 29079736; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual cysteinyl-tRNA synthetase; cysteine persulfide synthase" /protein_id="NP_387975.1" /db_xref="EnsemblGenomes-Gn:BSU00940" /db_xref="EnsemblGenomes-Tr:CAB11870" /db_xref="GOA:Q06752" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015273" /db_xref="InterPro:IPR015803" /db_xref="InterPro:IPR024909" /db_xref="InterPro:IPR032678" /db_xref="SubtiList:BG10156" /db_xref="UniProtKB/Swiss-Prot:Q06752" /translation="MTITLYNTLTRQKETFVPLEEGKVKMYVCGPTVYNYIHIGNARP AIVYDTVRNYLEYKGYDVQYVSNFTDVDDKLIKAANELGEDVPTISERFIKAYFEDVG ALGCRKADLHPRVMENMDAIIEFVDQLVKKGYAYESEGDVYFKTRAFEGYGKLSQQSI DELRSGARIRVGEKKEDALDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMVKKYLG DQIDIHAGGQDLTFPHHENEIAQSEALTGKTFAKYWLHNGYINIDNEKMSKSLGNFVL VHDIIKQHDPQLLRFFMLSVHYRHPINYSEELLENTKSAFSRLKTAYSNLQHRLNSST NLTEDDDQWLEKVEEHRKAFEEEMDDDFNTANAISVLFDLAKHANYYLQKDHTADHVI TAFIEMFDRIVSVLGFSLGEQELLDQEIEDLIEKRNEARRNRDFALSDQIRDQLKSMN IILEDTAQGTRWKRGE*" /label="cysS CDS" gene 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /label="cysS gene" CDS 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 25634891, 27924926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 25634891, 27924926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease for 23S RNA maturation, mini-RNase III" /protein_id="NP_387976.1" /db_xref="EnsemblGenomes-Gn:BSU00950" /db_xref="EnsemblGenomes-Tr:CAB11871" /db_xref="GOA:O31418" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR008226" /db_xref="InterPro:IPR036389" /db_xref="PDB:4OUN" /db_xref="SubtiList:BG12702" /db_xref="UniProtKB/Swiss-Prot:O31418" /translation="MLEFDTIKDSKQLNGLALAYIGDAIFEVYVRHHLLKQGFTKPND LHKKSSRIVSAKSQAEILFFLQNQSFFTEEEEAVLKRGRNAKSGTTPKNTDVQTYRYS TAFEALLGYLFLEKKEERLSQLVAEAIQFGTSGRKTNESAT*" /label="mrnC CDS" gene 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /label="mrnC gene" CDS 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /EC_number="2.1.1.185" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11698387, 12377117, 16014871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (Gm2251)-methyltransferase" /protein_id="NP_387977.1" /db_xref="EnsemblGenomes-Gn:BSU00960" /db_xref="EnsemblGenomes-Tr:CAB11872" /db_xref="GOA:Q06753" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR004441" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG10157" /db_xref="UniProtKB/Swiss-Prot:Q06753" /translation="MSQQHDYVIGKNAVIETLKSDRKLYKLWMAENTVKGQAQQVIEL AKKQGITIQYVPRKKLDQMVTGQHQGVVAQVAAYEYAELDDLYKAAEEKNEQPFFLIL DELEDPHNLGSIMRTADAVGAHGIVIPKRRAVGLTTTVAKASTGAIEHIPVARVTNLA RTLEEMKERGIWVVGTDASAREDFRNMDGNMPLALVIGSEGKGMGRLVKEKCDFLIKL PMAGKVTSLNASVAAGLLMYEVYRKRNPVGE*" /label="rlmB CDS" gene 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /label="rlmB gene" CDS 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17114934, 23355615, 28363943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17114934, 23355615, 28363943; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-dependent mRNA endonuclease" /protein_id="NP_387978.1" /db_xref="EnsemblGenomes-Gn:BSU00970" /db_xref="EnsemblGenomes-Tr:CAB11873" /db_xref="InterPro:IPR010298" /db_xref="PDB:5MQ8" /db_xref="PDB:5MQ9" /db_xref="SubtiList:BG10158" /db_xref="UniProtKB/Swiss-Prot:P37574" /translation="MDILLVDGYNMIGAWPQLKDLKANSFEEARDVLIQKMAEYQSYT GNRVIVVFDAHLVKGLEKKQTNHRVEVIFTKENETADERIEKLAQALNNIATQIHVAT SDYTEQWAIFGQGALRKSARELLREVETIERRIERRVRKITSEKPAGKIALSEEVLKT FEKWRRGDLD*" /label="raeA CDS" gene 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /label="raeA gene" promotor_-35 116127..116134 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 116149..116168 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 116151 /Source="Nicolas_upshifts" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169614, 16339734, 25288929, 26712348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169614, 16339734, 25288929, 26712348; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-30 factor (sigma(H))" /protein_id="NP_387979.1" /db_xref="EnsemblGenomes-Gn:BSU00980" /db_xref="EnsemblGenomes-Tr:CAB11874" /db_xref="GOA:P17869" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014218" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR016371" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10159" /db_xref="UniProtKB/Swiss-Prot:P17869" /translation="MNLQNNKGKFNKEQFCQLEDEQVIEKVHVGDSDALDYLITKYRN FVRAKARSYFLIGADREDIVQEGMIGLYKSIRDFKEDKLTSFKAFAELCITRQIITAI KTATRQKHIPLNSYASLDKPIFDEESDRTLLDVISGAKTLNPEEMIINQEEFDDIEMK MGELLSDLERKVLVLYLDGRSYQEISDELNRHVKSIDNALQRVKRKLEKYLEIREISL *" /label="sigH CDS" gene 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /label="sigH gene" downshifts complement(116645) /Source="Nicolas_upshifts" /id="D40" /incds=1 /nref=1 /ntot=107 /MaxReadThrough="2.38622" /MaxDrop="2.50464" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=836 /isTUend="FALSE" /label="downshifts" S_feature 116848..116939 /Source="Nicolas_S_feature" /locus_tag="new_117257_117348" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, S1, S2, T5.0H, HiOs, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S47" CDS 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586115, 19648245, 23002217, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586115, 19648245, 23002217, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_387980.1" /db_xref="EnsemblGenomes-Gn:BSU00990" /db_xref="EnsemblGenomes-Tr:CAB11875" /db_xref="GOA:Q06798" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="SubtiList:BG10160" /db_xref="UniProtKB/Swiss-Prot:Q06798" /translation="MRKKITLACKTCGNRNYTTMKSSASAAERLEVKKYCSTCNSHTA HLETK*" /label="rpmGB CDS" gene 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /label="rpmGB gene" CDS 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11976315, 12682299, 16242710, 22304380, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11976315, 12682299, 16242710, 22304380, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_387981.1" /db_xref="EnsemblGenomes-Gn:BSU01000" /db_xref="EnsemblGenomes-Tr:CAB11876" /db_xref="GOA:Q06799" /db_xref="InterPro:IPR001901" /db_xref="InterPro:IPR005807" /db_xref="InterPro:IPR022943" /db_xref="SubtiList:BG10161" /db_xref="UniProtKB/Swiss-Prot:Q06799" /translation="MRIMKFFKDVGKEMKKVSWPKGKELTRYTITVISTVIFFVIFFA LLDTGISQLIRLIVE*" /label="secE CDS" gene 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /label="secE gene" S_feature 117303..117480 /Source="Nicolas_S_feature" /locus_tag="new_117712_117889" /HighExp="Cold, G180, G150, H2O2, LoTm, Oxctl, G135, Paraq, LBGexp, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S48" downshifts complement(117474) /Source="Nicolas_upshifts" /id="D41" /incds=0 /nref=37 /ntot=175 /MaxReadThrough="1.57397" /MaxDrop="4.03552" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11101662, 16014871, 16707701, 18852477, 26742846, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101662, 16014871, 16707701, 18852477, 26742846, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase elongation pause factor" /protein_id="NP_387982.1" /db_xref="EnsemblGenomes-Gn:BSU01010" /db_xref="EnsemblGenomes-Tr:CAB11877" /db_xref="GOA:Q06795" /db_xref="InterPro:IPR001062" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR006645" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015869" /db_xref="InterPro:IPR036735" /db_xref="SubtiList:BG10162" /db_xref="UniProtKB/Swiss-Prot:Q06795" /translation="MEKNWYVVHTYSGYENKVKANLEKRVESMGMQDKIFRVVVPEEE ETDIKNGKKKVVKKKVFPGYVLVEIVMTDDSWYVVRNTPGVTGFVGSAGSGSKPTPLL PGEAETILKRMGMDERKTDIDFELKETVKVIDGPFANFTGSIEEIDYDKSKVKVFVNM FGRETPVELEFTQIDKL*" /label="nusG CDS" gene 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /label="nusG gene" upshifts complement(117569) /Source="Nicolas_upshifts" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(117572..117576) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(117591..117596) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 118025..118032 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 118043..118181 /Source="Nicolas_S_feature" /locus_tag="new_118452_118590" /HighExp="T-1.40H, ferm, T-3.40H, T-5.40H, BI, B36, LoTm, SMM, T-2.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S49" upshifts 118043 /Source="Nicolas_upshifts" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 118046..118065 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11244072, 19653700, 20441189" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244072, 19653700, 20441189; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 (BL11)" /protein_id="NP_387983.2" /db_xref="EnsemblGenomes-Gn:BSU01020" /db_xref="EnsemblGenomes-Tr:CAB11878" /db_xref="GOA:Q06796" /db_xref="InterPro:IPR000911" /db_xref="InterPro:IPR006519" /db_xref="InterPro:IPR020783" /db_xref="InterPro:IPR020784" /db_xref="InterPro:IPR020785" /db_xref="InterPro:IPR036769" /db_xref="InterPro:IPR036796" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG10163" /db_xref="UniProtKB/Swiss-Prot:Q06796" /translation="MAKKVVKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNA RTADQAGLIIPVEISVYEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATVKR DKVREIAETKMPDLNAADVEAAMRMVEGTARSMGIVIED*" /label="rplK CDS" gene 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /label="rplK gene" S_feature 118608..118701 /Source="Nicolas_S_feature" /locus_tag="new_119017_119110" /HighExp="HPh, LPh, Lbexp, G180, LBGexp, G150, Heat, Cold, Fru, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S50" CDS 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16352840, 17981968, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L1 (BL1)" /protein_id="NP_387984.2" /db_xref="EnsemblGenomes-Gn:BSU01030" /db_xref="EnsemblGenomes-Tr:CAB11879" /db_xref="GOA:Q06797" /db_xref="InterPro:IPR002143" /db_xref="InterPro:IPR005878" /db_xref="InterPro:IPR016095" /db_xref="InterPro:IPR023673" /db_xref="InterPro:IPR023674" /db_xref="InterPro:IPR028364" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="SubtiList:BG10164" /db_xref="UniProtKB/Swiss-Prot:Q06797" /translation="MAKKGKKYVEAAKLVDRSKAYDVSEAVALVKKTNTAKFDATVEV AFRLGVDPRKNDQQIRGAVVLPNGTGKTQRVLVFAKGEKAKEAEAAGADFVGDTDYIN KIQQGWFDFDVIVATPDMMGEVGKIGRVLGPKGLMPNPKTGTVTFEVEKAIGEIKAGK VEYRVDKAGNIHVPIGKVSFEDEKLVENFTTMYDTILKAKPAAAKGVYVKNVAVTSTM GPGVKVDSSTFNVK*" /label="rplA CDS" gene 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /label="rplA gene" downshifts complement(119374) /Source="Nicolas_upshifts" /id="D42" /incds=0 /nref=3 /ntot=95 /MaxReadThrough="3.54108" /MaxDrop="3.36566" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U89" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /product="L10_leader" /experiment="publication(s) with functional evidences, PMID:26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26101249; Product type n: RNA" /label="ldlJ RNA" gene 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /label="ldlJ gene" upshifts complement(119462) /Source="Nicolas_upshifts" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(119465..119469) /Source="Nicolas_upshift_promotors" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 119518 /Source="Nicolas_upshifts" /id="D43" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="9.14839" /MaxDrop="2.9211" /score="20.0562348" /energy="-13.2" /TU="U88" /idTUdmin="U84" /TUdmin=1497 /isTUend="FALSE" /label="downshifts" CDS 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9810686, 11341315, 12682299, 18247578, 26101249, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9810686, 11341315, 12682299, 18247578, 26101249, 22720735; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L10 (BL5)" /protein_id="NP_387985.2" /db_xref="EnsemblGenomes-Gn:BSU01040" /db_xref="EnsemblGenomes-Tr:CAB11880" /db_xref="GOA:P42923" /db_xref="InterPro:IPR001790" /db_xref="InterPro:IPR002363" /db_xref="InterPro:IPR022973" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11220" /db_xref="UniProtKB/Swiss-Prot:P42923" /translation="MSSAIETKKVVVEEIASKLKESKSTIIVDYRGLNVSEVTELRKQ LREANVEFKVYKNTMTRRAVEQAELNGLNDFLTGPNAIAFSTEDVVAPAKVLNDFAKN HEALEIKAGVIEGKVSTVEEVKALAELPSREGLLSMLLSVLQAPVRNLALAAKAVAEQ KEEQGA*" /label="rplJ CDS" gene 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /label="rplJ gene" CDS 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 6771249, 8755892, 26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 6771249, 8755892, 26101249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L12 (BL9)" /protein_id="NP_387986.1" /db_xref="EnsemblGenomes-Gn:BSU01050" /db_xref="EnsemblGenomes-Tr:CAB11881" /db_xref="GOA:P02394" /db_xref="InterPro:IPR000206" /db_xref="InterPro:IPR008932" /db_xref="InterPro:IPR013823" /db_xref="InterPro:IPR014719" /db_xref="InterPro:IPR036235" /db_xref="SubtiList:BG10726" /db_xref="UniProtKB/Swiss-Prot:P02394" /translation="MALNIEEIIASVKEATVLELNDLVKAIEEEFGVTAAAPVAVAGG AAAGGAAEEQSEFDLILAGAGSQKIKVIKVVREITGLGLKEAKELVDNTPKPLKEGIA KEEAEELKAKLEEVGASVEVK*" /label="rplL CDS" gene 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /label="rplL gene" downshifts 120485 /Source="Nicolas_upshifts" /id="D44" /incds=1 /nref=5 /ntot=149 /MaxReadThrough="8.89506" /MaxDrop="4.0945" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2464 /isTUend="FALSE" /label="downshifts" downshifts 120558 /Source="Nicolas_upshifts" /id="D45" /incds=0 /nref=25 /ntot=157 /MaxReadThrough="7.44654" /MaxDrop="4.0033" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2537 /isTUend="FALSE" /label="downshifts" CDS 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /EC_number="2.1.1.174" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17010380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2G1835 methyltransferase" /protein_id="NP_387987.1" /db_xref="EnsemblGenomes-Gn:BSU01060" /db_xref="EnsemblGenomes-Tr:CAB11882" /db_xref="GOA:P37872" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10727" /db_xref="UniProtKB/Swiss-Prot:P37872" /translation="MSEHYYSEKPSVKSNKQTWSFRLRNKDFTFTSDSGVFSKKEVDF GSRLLIDSFEEPEVEGGILDVGCGYGPIGLSLASDFKDRTIHMIDVNERAVELSNENA EQNGITNVKIYQSDLFSNVDSAQTFASILTNPPIRAGKKVVHAIFEKSAEHLKASGEL WIVIQKKQGAPSAIEKLEELFDEVSVVQKKKGYYIIKAKKV*" /label="rlmG CDS" gene 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /label="rlmG gene" promotor_-35 121259..121263 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 121277..121509 /Source="Nicolas_S_feature" /locus_tag="new_121686_121918" /HighExp="G180, G150, H2O2, G135, Cold, T-5.40H, LoTm, T-3.40H, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S51" upshifts 121277 /Source="Nicolas_upshifts" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 121279..121298 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10049799, 10744988, 12455702, 12682299, 15060052, 28163698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10049799, 10744988, 12455702, 12682299, 15060052, 28163698; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta subunit)" /protein_id="NP_387988.2" /db_xref="EnsemblGenomes-Gn:BSU01070" /db_xref="EnsemblGenomes-Tr:CAB11883" /db_xref="GOA:P37870" /db_xref="InterPro:IPR007120" /db_xref="InterPro:IPR007121" /db_xref="InterPro:IPR007641" /db_xref="InterPro:IPR007642" /db_xref="InterPro:IPR007644" /db_xref="InterPro:IPR007645" /db_xref="InterPro:IPR010243" /db_xref="InterPro:IPR015712" /db_xref="InterPro:IPR019462" /db_xref="PDB:2LY7" /db_xref="SubtiList:BG10728" /db_xref="UniProtKB/Swiss-Prot:P37870" /translation="MTGQLVQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEG LREMFQDISPIEDFTGNLSLEFIDYSLGEPKYPVEESKERDVTYSAPLRVKVRLINKE TGEVKDQDVFMGDFPIMTDTGTFIINGAERVIVSQLVRSPSVYFSGKVDKNGKKGFTA TVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFGSDQEILDLIGENEYLR NTLDKDNTENSDKALLEIYERLRPGEPPTVENAKSLLDSRFFDPKRYDLANVGRYKIN KKLHIKNRLFNQRLAETLVDPETGEILAEKGQILDRRTLDKVLPYLENGIGFRKLYPN GGVVEDEVTLQSIKIFAPTDQEGEQVINVIGNAYIEEEIKNITPADIISSISYFFNLL HGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTNTITPQQLIN IRPVIASIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGMEVRDVHY SHYGRMCPIETPEGPNIGLINSLSSYAKVNRFGFIETPYRRVDPETGKVTGRIDYLTA DEEDNYVVAQANARLDDEGAFIDDSIVARFRGENTVVSRNRVDYMDVSPKQVVSAATA CIPFLENDDSNRALMGANMQRQAVPLMQPEAPFVGTGMEYVSGKDSGAAVICKHPGIV ERVEAKNVWVRRYEEVDGQKVKGNLDKYSLLKFVRSNQGTCYNQRPIVSVGDEVVKGE ILADGPSMELGELALGRNVMVGFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEYESE ARDTKLGPEEITRDIPNVGEDALRNLDDRGIIRIGAEVKDGDLLVGKVTPKGVTELTA EERLLHAIFGEKAREVRDTSLRVPHGGGGIIHDVKVFNREDGDELPPGVNQLVRVYIV QKRKISEGDKMAGRHGNKGVISKILPEEDMPYLPDGTPIDIMLNPLGVPSRMNIGQVL ELHMGMAARYLGIHIASPVFDGAREEDVWETLEEAGMSRDAKTVLYDGRTGEPFDNRV SVGIMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGA AYTLQEILTVKSDDVVGRVKTYEAIVKGDNVPEPGVPESFKVLIKELQSLGMDVKILS GDEEEIEMRDLEDEEDAKQADGLALSGDEEPEETASADVERDVVTKE*" /label="rpoB CDS" gene 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /label="rpoB gene" promotor_-10 complement(123095..123114) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123098) /Source="Nicolas_upshifts" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123128..123137) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(123966..123970) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123971) /Source="Nicolas_upshifts" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123985..123991) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta' subunit)" /protein_id="NP_387989.2" /db_xref="EnsemblGenomes-Gn:BSU01080" /db_xref="EnsemblGenomes-Tr:CAB11884" /db_xref="GOA:P37871" /db_xref="InterPro:IPR000722" /db_xref="InterPro:IPR006592" /db_xref="InterPro:IPR007066" /db_xref="InterPro:IPR007080" /db_xref="InterPro:IPR007081" /db_xref="InterPro:IPR007083" /db_xref="InterPro:IPR012754" /db_xref="SubtiList:BG10729" /db_xref="UniProtKB/Swiss-Prot:P37871" /translation="MLDVNNFEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKD GLFCERIFGPTKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPVS HIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLSEKEYRAYLD KYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQRRTRAIKRLEVLEAFRN SGNKPSWMILDVLPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGA PSIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGK RVDYSGRSVIVVGPHLKMYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIER VQPEVWDVLESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADF DGDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERAG AVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLKNVTFTEEQRSKLLITTVGKLV FNEILPESFPYMNEPTKSNIEEKTPDRFFLEKGADVKAVIAQQPINAPFKKGILGKII AEIFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQEILEEAQSKVDN VMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLDELNPIYMMSDSGARGNASN FTQLAGMRGLMANPAGRIIELPIKSSFREGLTVLEYFISTHGARKGLADTALKTADSG YLTRRLVDVAQDVIIRETDCGTDRGILAKPLKEGTETIERLEERLIGRFARKQVKHPE TGEVLVNENELIDEDKALEIVEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVE VGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRIQELFEARNPKGQATIT EIDGTVVEINEVRDKQQEIVVQGAVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSID PKELLKVTDLTTVQEYLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVIDAGDTDV LPGTLLDIHQFTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETTRVL TDAAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKPVSNVQPTDDMVPVE*" /label="rpoC CDS" gene 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /label="rpoC gene" downshifts complement(128217) /Source="Nicolas_upshifts" /id="D46" /incds=1 /nref=1 /ntot=76 /MaxReadThrough="3.40002" /MaxDrop="2.38911" /score="-2.05539956" /energy="-7.5" /TU="U93" /idTUdmin="U93" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" upshifts complement(128371) /Source="Nicolas_upshifts" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(128389..128390) /Source="Nicolas_upshift_promotors" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(128701) /Source="Nicolas_upshifts" /id="D47" /incds=0 /nref=98 /ntot=210 /MaxReadThrough="1.61828" /MaxDrop="4.90549" /score="-2.05539956" /energy="-7.5" /TU="NA" /idTUdmin="U95" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 128753..128874 /Source="Nicolas_S_feature" /locus_tag="new_129162_129283" /HighExp="LoTm, HiOs, S3, SMMPr, Heat, S1, BC, Glu, S4, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S52" promotor_-35 128856..128863 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" upshifts 128876 /Source="Nicolas_upshifts" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 128877..128896 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" misc_feature complement(128894..128898) /Source="Nicolas_upshift_promotors" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(128897) /Source="Nicolas_upshifts" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein; alternative ribosomal protein L7A" /protein_id="NP_387990.1" /db_xref="EnsemblGenomes-Gn:BSU01090" /db_xref="EnsemblGenomes-Tr:CAB11885" /db_xref="GOA:P46350" /db_xref="InterPro:IPR000948" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR023460" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7E" /db_xref="PDB:4LCK" /db_xref="PDB:4TZP" /db_xref="PDB:4TZV" /db_xref="PDB:4TZW" /db_xref="PDB:4TZZ" /db_xref="SubtiList:BG11365" /db_xref="UniProtKB/Swiss-Prot:P46350" /translation="MSYDKVSQAKSIIIGTKQTVKALKRGSVKEVVVAKDADPILTSS VVSLAEDQGISVSMVESMKKLGKACGIEVGAAAVAIIL*" /label="rulS CDS" gene 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /label="rulS gene" S_feature 129180..129292 /Source="Nicolas_S_feature" /locus_tag="new_129589_129701" /HighExp="T-3.40H, M/G, T-1.40H, T-5.40H, Salt, Mal, T-0.40H, G/S, M9-exp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S53" CDS 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11489846, 12682299, 16484214, 18252828, 19383706, 20007320" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489846, 12682299, 16484214, 18252828, 19383706, 20007320; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S12 (BS12)" /protein_id="NP_387991.2" /db_xref="EnsemblGenomes-Gn:BSU01100" /db_xref="EnsemblGenomes-Tr:CAB11886" /db_xref="GOA:P21472" /db_xref="InterPro:IPR005679" /db_xref="InterPro:IPR006032" /db_xref="InterPro:IPR012340" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19009" /db_xref="UniProtKB/Swiss-Prot:P21472" /translation="MPTINQLIRKGRVSKVENSKSPALNKGYNSFKKEHTNVSSPQKR GVCTRVGTMTPKKPNSALRKYARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKD LPGVRYHIVRGALDTAGVENRAQGRSKYGTKKPKAK*" /label="rpsL CDS" gene 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /label="rpsL gene" CDS 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 19653700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 19653700; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S7 (BS7)" /protein_id="NP_387992.2" /db_xref="EnsemblGenomes-Gn:BSU01110" /db_xref="EnsemblGenomes-Tr:CAB11887" /db_xref="GOA:P21469" /db_xref="InterPro:IPR000235" /db_xref="InterPro:IPR005717" /db_xref="InterPro:IPR020606" /db_xref="InterPro:IPR023798" /db_xref="InterPro:IPR036823" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19006" /db_xref="UniProtKB/Swiss-Prot:P21469" /translation="MPRKGPVAKRDVLPDPIYNSKLVSRLINKMMIDGKKGKSQTILY KSFDIIKERTGNDAMEVFEQALKNIMPVLEVKARRVGGANYQVPVEVRPERRTTLGLR WLVNYARLRGEKTMEERLANEILDAANNTGAAVKKREDTHKMAEANKAFAHYRW*" /label="rpsG CDS" gene 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /label="rpsG gene" CDS 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:815236, 815243, 1556067, 4629789, 19366171, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 815236, 815243, 1556067, 4629789, 19366171, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="elongation factor G" /protein_id="NP_387993.2" /db_xref="EnsemblGenomes-Gn:BSU01120" /db_xref="EnsemblGenomes-Tr:CAB11888" /db_xref="GOA:P80868" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004540" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005517" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009022" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035649" /db_xref="PDB:5VH6" /db_xref="SubtiList:BG11939" /db_xref="UniProtKB/Swiss-Prot:P80868" /translation="MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETH EGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGA VAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTLRDRLQANAH AIQLPIGAEDNFEGIIDLVENVAYFYEDDLGTRSDAKEIPEEYKEQAEELRNSLIEAV CELDEELMDKYLEGEEITIDELKAGIRKGTLNVEFYPVLVGSAFKNKGVQLVLDAVLD YLPAPTDVAAIKGTRPDTNEEIERHSSDEEPFSALAFKVMTDPYVGKLTFFRVYSGTL DSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEK DLVILESMEFPEPVIDVAIEPKSKADQDKMGIALAKLAEEDPTFRTQTNPETGQTIIS GMGELHLDIIVDRMKREFKVEANVGAPQVAYRETFRTGAKVEGKFVRQSGGRGQFGHV WIEFEPNEEGAGFEFENAIVGGVVPREYIPAVQAGLEDALENGVLAGFPLIDIKAKLF DGSYHDVDSNEMAFKVAASMALKNAVSKCNPVLLEPIMKVEVVIPEEYMGDIMGDITS RRGRVEGMEARGNAQVVRAMVPLAEMFGYATALRSNTQGRGTFTMHMDHYEEVPKSVA EEIIKKNKGE*" /label="fusA CDS" gene 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /label="fusA gene" S_feature 132354..132472 /Source="Nicolas_S_feature" /locus_tag="new_132763_132881" /HighExp="T-5.40H, T-4.40H, UNK1, SMM, HiTm, T-3.40H, T-2.40H, SMMPr, MG 90, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S54" CDS 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10774755, 12682299, 7706132, 20133608, 22938038, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10774755, 12682299, 7706132, 20133608, 22938038, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="elongation factor Tu" /protein_id="NP_387994.1" /db_xref="EnsemblGenomes-Gn:BSU01130" /db_xref="EnsemblGenomes-Tr:CAB11889" /db_xref="GOA:P33166" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004160" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004541" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR033720" /db_xref="SubtiList:BG11056" /db_xref="UniProtKB/Swiss-Prot:P33166" /translation="MAKEKFDRSKSHANIGTIGHVDHGKTTLTAAITTVLHKKSGKGT AMAYDQIDGAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDG AILVVSAADGPMPQTREHILLSKNVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLS EYDFPGDDVPVVKGSALKALEGDAEWEAKIFELMDAVDEYIPTPERDTEKPFMMPVED VFSITGRGTVATGRVERGQVKVGDEVEIIGLQEENKKTTVTGVEMFRKLLDYAEAGDN IGALLRGVSREEIQRGQVLAKPGTITPHSKFKAEVYVLSKEEGGRHTPFFSNYRPQFY FRTTDVTGIIHLPEGVEMVMPGDNTEMNVELISTIAIEEGTRFSIREGGRTVGSGVVS TITE*" /label="tufA CDS" gene 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /label="tufA gene" downshifts 133658 /Source="Nicolas_upshifts" /id="D48" /incds=0 /nref=258 /ntot=269 /MaxReadThrough="4.84568" /MaxDrop="8.56168" /score="39.3984056" /energy="-12.9" /TU="U88,U90,U94" /idTUdmin="U88" /TUdmin="-1081" /isTUend="FALSE" /label="downshifts" misc_feature complement(133689..133692) /Source="Nicolas_upshift_promotors" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(133693) /Source="Nicolas_upshifts" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 133719..133738 /Source="Nicolas_upshift_promotors" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 133727 /Source="Nicolas_upshifts" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /EC_number="3.4.11.5" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proline iminopeptidase" /protein_id="NP_387995.2" /db_xref="EnsemblGenomes-Gn:BSU01140" /db_xref="EnsemblGenomes-Tr:CAB11890" /db_xref="GOA:P70981" /db_xref="InterPro:IPR002410" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11988" /db_xref="UniProtKB/Swiss-Prot:P70981" /translation="MIPEKKSIAIMKELSIGNTKQMLMINGVDVKNPLLLFLHGGPGT PQIGYVRHYQKELEQYFTVVHWDQRGSGLSYSKRISHHSMTINHFIKDTIQVTQWLLA HFSKSKLYLAGHSWGSILALHVLQQRPDLFYTYYGISQVVNPQDEESTAYQHIREISE SKKASILSFLTRFIGAPPWKQDIQHLIYRFCVELTRGGFTHRHRQSLAVLFQMLTGNE YGVRNMHSFLNGLRFSKKHLTDELYRFNAFTSVPSIKVPCVFISGKHDLIVPAEISKQ YYQELEAPEKRWFQFENSAHTPHIEEPSLFANTLSRHARHHL*" /label="ybaC CDS" gene 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /label="ybaC gene" promotor_-35 134725..134732 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 134746..134765 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 134761..134954 /Source="Nicolas_S_feature" /locus_tag="new_135170_135363" /HighExp="T-1.40H, T-2.40H, T-1.10H, SMM, T-3.40H, T-4.40H, BI, BMM, H2O2, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S55" upshifts 134761 /Source="Nicolas_upshifts" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 27964882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 27964882; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S10 (BS13); transcription antitermination factor" /protein_id="NP_387996.1" /db_xref="EnsemblGenomes-Gn:BSU01150" /db_xref="EnsemblGenomes-Tr:CAB11891" /db_xref="GOA:P21471" /db_xref="InterPro:IPR001848" /db_xref="InterPro:IPR018268" /db_xref="InterPro:IPR027486" /db_xref="InterPro:IPR036838" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19008" /db_xref="UniProtKB/Swiss-Prot:P21471" /translation="MAKQKIRIRLKAYDHRILDQSAEKIVETAKRSGASVSGPIPLPT EKSVYTILRAVHKYKDSREQFEMRTHKRLIDIVNPTPQTVDALMRLDLPSGVDIEIKL *" /label="rpsJ CDS" gene 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /label="rpsJ gene" CDS 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 19154332, 23759864" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 19154332, 23759864; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L3 (BL3)" /protein_id="NP_387997.1" /db_xref="EnsemblGenomes-Gn:BSU01160" /db_xref="EnsemblGenomes-Tr:CAB11892" /db_xref="GOA:P42920" /db_xref="InterPro:IPR000597" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR019926" /db_xref="InterPro:IPR019927" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11218" /db_xref="UniProtKB/Swiss-Prot:P42920" /translation="MTKGILGRKIGMTQVFAENGDLIPVTVIEAAPNVVLQKKTAEND GYEAIQLGFDDKREKLSNKPEKGHVAKAETAPKRFVKELRGVEMDAYEVGQEVKVEIF SAGEIVDVTGVSKGKGFQGAIKRHGQSRGPMSHGSRYHRRPGSMGPVDPNRVFKGKLL PGRMGGEQITVQNLEIVKVDAERNLLLIKGNVPGAKKSLITVKSAVKSK*" /label="rplC CDS" gene 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /label="rplC gene" CDS 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10898684, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L4" /protein_id="NP_387998.1" /db_xref="EnsemblGenomes-Gn:BSU01170" /db_xref="EnsemblGenomes-Tr:CAB11893" /db_xref="GOA:P42921" /db_xref="InterPro:IPR002136" /db_xref="InterPro:IPR013005" /db_xref="InterPro:IPR023574" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11219" /db_xref="UniProtKB/Swiss-Prot:P42921" /translation="MPKVALYNQNGSTAGDIELNASVFGIEPNESVVFDAILMQRASL RQGTHKVKNRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYSYKLP KKVRRLAIKSVLSSKVIDNNIIVLEDLTLDTAKTKEMAAILKGLSVEKKALIVTADAN EAVALSARNIPGVTVVEANGINVLDVVNHEKLLITKAAVEKVEEVLA*" /label="rplD CDS" gene 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /label="rplD gene" CDS 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L23" /protein_id="NP_387999.2" /db_xref="EnsemblGenomes-Gn:BSU01180" /db_xref="EnsemblGenomes-Tr:CAB11894" /db_xref="GOA:P42924" /db_xref="InterPro:IPR001014" /db_xref="InterPro:IPR012678" /db_xref="InterPro:IPR013025" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11221" /db_xref="UniProtKB/Swiss-Prot:P42924" /translation="MKDPRDVLKRPVITERSADLMTEKKYTFEVDVRANKTEVKDAVE SIFGVKVDKVNIMNYKGKSKRVGRYTGMTSRRRKAIVKLTADSKEIEIFEA*" /label="rplW CDS" gene 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /label="rplW gene" CDS 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23249812, 24637032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23249812, 24637032; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L2 (BL2)" /protein_id="NP_388000.2" /db_xref="EnsemblGenomes-Gn:BSU01190" /db_xref="EnsemblGenomes-Tr:CAB11895" /db_xref="GOA:P42919" /db_xref="InterPro:IPR002171" /db_xref="InterPro:IPR005880" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR014726" /db_xref="InterPro:IPR022666" /db_xref="InterPro:IPR022669" /db_xref="InterPro:IPR022671" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11217" /db_xref="UniProtKB/Swiss-Prot:P42919" /translation="MAIKKYKPTSNGRRGMTTSDFAEITTDKPEKSLLAPLHKKGGRN NQGKLTVRHQGGGHKRQYRVIDFKRDKDGIPGRVATVEYDPNRSANIALINYADGEKR YILAPKGIQVGTEIMSGPEADIKVGNALPLINIPVGTVVHNIELKPGKGGQLVRSAGT SAQVLGKEGKYVLVRLNSGEVRMILSACRASIGQVGNEQHELINIGKAGRSRWKGIRP TVRGSVMNPNDHPHGGGEGRAPIGRKSPMSPWGKPTLGFKTRKKKNKSDKFIVRRRKN K*" /label="rplB CDS" gene 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /label="rplB gene" downshifts complement(137038) /Source="Nicolas_upshifts" /id="D49" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="3.39972" /MaxDrop="4.09052" /score="-4.16840603" /energy="-12.8" /TU="NA" /idTUdmin="U99" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" CDS 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S19 (BS19)" /protein_id="NP_388001.1" /db_xref="EnsemblGenomes-Gn:BSU01200" /db_xref="EnsemblGenomes-Tr:CAB11896" /db_xref="GOA:P21476" /db_xref="InterPro:IPR002222" /db_xref="InterPro:IPR005732" /db_xref="InterPro:IPR020934" /db_xref="InterPro:IPR023575" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19011" /db_xref="UniProtKB/Swiss-Prot:P21476" /translation="MARSLKKGPFVDGHLMTKIEKLNETDKKQVVKTWSRRSTIFPQF IGHTIAVYDGRKHVPVFISEDMVGHKLGEFAPTRTYKGHASDDKKTRR*" /label="rpsS CDS" gene 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /label="rpsS gene" CDS 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7928988, 12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7928988, 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L22 (BL17)" /protein_id="NP_388002.1" /db_xref="EnsemblGenomes-Gn:BSU01210" /db_xref="EnsemblGenomes-Tr:CAB11897" /db_xref="GOA:P42060" /db_xref="InterPro:IPR001063" /db_xref="InterPro:IPR005727" /db_xref="InterPro:IPR018260" /db_xref="InterPro:IPR036394" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11078" /db_xref="UniProtKB/Swiss-Prot:P42060" /translation="MQAKAVARTVRIAPRKARLVMDLIRGKQVGEAVSILNLTPRAAS PIIEKVLKSAIANAEHNYEMDANNLVISQAFVDEGPTLKRFRPRAMGRASQINKRTSH ITIVVSEKKEG*" /label="rplV CDS" gene 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /label="rplV gene" CDS 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S3 (BS3)" /protein_id="NP_388003.2" /db_xref="EnsemblGenomes-Gn:BSU01220" /db_xref="EnsemblGenomes-Tr:CAB11898" /db_xref="GOA:P21465" /db_xref="InterPro:IPR001351" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR005704" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR018280" /db_xref="InterPro:IPR036419" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19005" /db_xref="UniProtKB/Swiss-Prot:P21465" /translation="MGQKVNPVGLRIGVIRDWESKWYAGKDYADFLHEDLKIREYISK RLSDASVSKVEIERAANRVNITIHTAKPGMVIGKGGSEVEALRKALNSLTGKRVHINI LEIKRADLDAQLVADNIARQLENRVSFRRAQKQQIQRTMRAGAQGVKTMVSGRLGGAD IARSEYYSEGTVPLHTLRADIDYATSEADTTYGKLGVKVWIYRGEVLPTKKKNEEGGK *" /label="rpsC CDS" gene 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /label="rpsC gene" downshifts complement(138446) /Source="Nicolas_upshifts" /id="D50" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="3.68388" /MaxDrop="2.1922" /score="-4.16840603" /energy="-12.8" /TU="U99" /idTUdmin="U99" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(138527..138531) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(138534) /Source="Nicolas_upshifts" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(138548..138550) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L16" /protein_id="NP_388004.1" /db_xref="EnsemblGenomes-Gn:BSU01230" /db_xref="EnsemblGenomes-Tr:CAB11899" /db_xref="GOA:P14577" /db_xref="InterPro:IPR000114" /db_xref="InterPro:IPR016180" /db_xref="InterPro:IPR020798" /db_xref="InterPro:IPR036920" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10755" /db_xref="UniProtKB/Swiss-Prot:P14577" /translation="MLLPKRVKYRREHRGKMRGRAKGGTEVHFGEFGIQALEASWITN RQIEAARIAMTRYMKRGGKVWIKIFPSKPYTAKPLEVRMGSGKGAPEGWVAVVKPGKV LFEISGVSEEVAREALRLASHKLPIKTKFVKREEIGGESNES*" /label="rplP CDS" gene 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /label="rplP gene" CDS 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L29" /protein_id="NP_388005.1" /db_xref="EnsemblGenomes-Gn:BSU01240" /db_xref="EnsemblGenomes-Tr:CAB11900" /db_xref="GOA:P12873" /db_xref="InterPro:IPR001854" /db_xref="InterPro:IPR018254" /db_xref="InterPro:IPR036049" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10756" /db_xref="UniProtKB/Swiss-Prot:P12873" /translation="MKANEIRDLTTAEIEQKVKSLKEELFNLRFQLATGQLENTARIR EVRKAIARMKTVIREREIAANK*" /label="rpmC CDS" gene 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /label="rpmC gene" CDS 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S17 (BS16)" /protein_id="NP_388006.1" /db_xref="EnsemblGenomes-Gn:BSU01250" /db_xref="EnsemblGenomes-Tr:CAB11901" /db_xref="GOA:P12874" /db_xref="InterPro:IPR000266" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019979" /db_xref="InterPro:IPR019984" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10757" /db_xref="UniProtKB/Swiss-Prot:P12874" /translation="MSERNQRKVYQGRVVSDKMDKTITVVVETYKKHTLYGKRVKYSK KFKAHDENNQAKIGDIVKIMETRPLSATKRFRLVEVVEEAVII*" /label="rpsQ CDS" gene 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /label="rpsQ gene" CDS 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 8805509, 12682299, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 8805509, 12682299, 22829778; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L14" /protein_id="NP_388007.1" /db_xref="EnsemblGenomes-Gn:BSU01260" /db_xref="EnsemblGenomes-Tr:CAB11902" /db_xref="GOA:P12875" /db_xref="InterPro:IPR000218" /db_xref="InterPro:IPR005745" /db_xref="InterPro:IPR019972" /db_xref="InterPro:IPR036853" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10758" /db_xref="UniProtKB/Swiss-Prot:P12875" /translation="MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVK QATPGGVVKKGEVVKAVIVRTKSGARRSDGSYISFDENACVIIRDDKSPRGTRIFGPV ARELRENNFMKIVSLAPEVI*" /label="rplNA CDS" gene 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /label="rplNA gene" CDS 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11278078, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11278078, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L24 (BL23)" /protein_id="NP_388008.1" /db_xref="EnsemblGenomes-Gn:BSU01270" /db_xref="EnsemblGenomes-Tr:CAB11903" /db_xref="GOA:P0CI78" /db_xref="InterPro:IPR003256" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR005825" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10759" /db_xref="UniProtKB/Swiss-Prot:P0CI78" /translation="MHVKKGDKVMVISGKDKGKQGTILAAFPKKDRVLVEGVNMVKKH SKPTQANPQGGISNQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLD K*" /label="rplX CDS" gene 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /label="rplX gene" CDS 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L5 (BL6)" /protein_id="NP_388009.1" /db_xref="EnsemblGenomes-Gn:BSU01280" /db_xref="EnsemblGenomes-Tr:CAB11904" /db_xref="GOA:P12877" /db_xref="InterPro:IPR002132" /db_xref="InterPro:IPR020929" /db_xref="InterPro:IPR020930" /db_xref="InterPro:IPR022803" /db_xref="InterPro:IPR031309" /db_xref="InterPro:IPR031310" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10760" /db_xref="UniProtKB/Swiss-Prot:P12877" /translation="MNRLKEKYNKEIAPALMTKFNYDSVMQVPKIEKIVINMGVGDAV QNAKAIDSAVEELTFIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGERMYDFLDK LISVSLPRVRDFRGVSKKSFDGRGNYTLGIKEQLIFPEIDYDKVTKVRGMDIVIVTTA NTDEEARELLTQVGMPFQK*" /label="rplE CDS" gene 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /label="rplE gene" CDS 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17163968, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17163968, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S14" /protein_id="NP_388010.1" /db_xref="EnsemblGenomes-Gn:BSU01290" /db_xref="EnsemblGenomes-Tr:CAB11905" /db_xref="GOA:P12878" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023053" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10761" /db_xref="UniProtKB/Swiss-Prot:P12878" /translation="MAKKSMIAKQQRTPKFKVQEYTRCERCGRPHSVIRKFKLCRICF RELAYKGQIPGVKKASW*" /label="rpsNA CDS" gene 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /label="rpsNA gene" CDS 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S8 (BS8)" /protein_id="NP_388011.2" /db_xref="EnsemblGenomes-Gn:BSU01300" /db_xref="EnsemblGenomes-Tr:CAB11906" /db_xref="GOA:P12879" /db_xref="InterPro:IPR000630" /db_xref="InterPro:IPR035987" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10762" /db_xref="UniProtKB/Swiss-Prot:P12879" /translation="MVMTDPIADMLTRIRNANMVRHEKLEIPASKLKREIAEILKREG FIRDVEFVEDSKQGIIRVFLKYGQNNERVITGLKRISKPGLRVYAKSNEVPRVLNGLG IAIISTSQGVLTDKEARAKQAGGEVLAYVW*" /label="rpsH CDS" gene 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /label="rpsH gene" downshifts complement(141966) /Source="Nicolas_upshifts" /id="D51" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="2.68318" /MaxDrop="2.55712" /score="5.40276403" /energy="-15.9" /TU="NA" /idTUdmin="U99" /TUdmin="-3586" /isTUend="FALSE" /label="downshifts" CDS 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 25330043; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L6 (BL8)" /protein_id="NP_388012.1" /db_xref="EnsemblGenomes-Gn:BSU01310" /db_xref="EnsemblGenomes-Tr:CAB11907" /db_xref="GOA:P46898" /db_xref="InterPro:IPR000702" /db_xref="InterPro:IPR002358" /db_xref="InterPro:IPR019906" /db_xref="InterPro:IPR020040" /db_xref="InterPro:IPR036789" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11408" /db_xref="UniProtKB/Swiss-Prot:P46898" /translation="MSRVGKKLLEIPSDVTVTLNDNNTVAVKGPKGELTRTFHPDMEI KVEDNVLTVARPSDQKEHRALHGTTRSLLGNMVEGVSKGFERGLELVGVGYRASKSGN KLVLNVGYSHPVEIVPEEGIEIEVPSQTKVVVKGTDKERVGAIAANIRAVRSPEPYKG KGIRYEGEVVRRKEGKSAK*" /label="rplF CDS" gene 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /label="rplF gene" CDS 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L18" /protein_id="NP_388013.2" /db_xref="EnsemblGenomes-Gn:BSU01320" /db_xref="EnsemblGenomes-Tr:CAB11908" /db_xref="GOA:P46899" /db_xref="InterPro:IPR004389" /db_xref="InterPro:IPR005484" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11409" /db_xref="UniProtKB/Swiss-Prot:P46899" /translation="MITKTSKNAARLKRHARVRAKLSGTAERPRLNVFRSNKHIYAQI IDDVNGVTLASASTLDKDLNVESTGDTSAATKVGELVAKRAAEKGISDVVFDRGGYLY HGRVKALADAAREAGLKF*" /label="rplR CDS" gene 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /label="rplR gene" CDS 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6211592, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6211592, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S5" /protein_id="NP_388014.1" /db_xref="EnsemblGenomes-Gn:BSU01330" /db_xref="EnsemblGenomes-Tr:CAB11909" /db_xref="GOA:P21467" /db_xref="InterPro:IPR000851" /db_xref="InterPro:IPR005324" /db_xref="InterPro:IPR005712" /db_xref="InterPro:IPR013810" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018192" /db_xref="InterPro:IPR020568" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10442" /db_xref="UniProtKB/Swiss-Prot:P21467" /translation="MRRIDPSKLELEERLVTVNRVAKVVKGGRRFRFAALVVVGDKNG HVGFGTGKAQEVPEAIRKAVEDAKKNLIEVPMVGTTIPHEIIGRFGAGNILLKPASEG TGVIAGGPVRAVLELAGVADILSKSLGSNTPINMIRATLQGLSELKRAEDVAKLRGKS VEELLG*" /label="rpsE CDS" gene 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /label="rpsE gene" CDS 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L30 (BL27)" /protein_id="NP_388015.1" /db_xref="EnsemblGenomes-Gn:BSU01340" /db_xref="EnsemblGenomes-Tr:CAB11910" /db_xref="GOA:P19947" /db_xref="InterPro:IPR005996" /db_xref="InterPro:IPR016082" /db_xref="InterPro:IPR018038" /db_xref="InterPro:IPR036919" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10443" /db_xref="UniProtKB/Swiss-Prot:P19947" /translation="MAKLEITLKRSVIGRPEDQRVTVRTLGLKKTNQTVVHEDNAAIR GMINKVSHLVSVKEQ*" /label="rpmD CDS" gene 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /label="rpmD gene" CDS 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15855514, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15855514, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L15" /protein_id="NP_388016.1" /db_xref="EnsemblGenomes-Gn:BSU01350" /db_xref="EnsemblGenomes-Tr:CAB11911" /db_xref="GOA:P19946" /db_xref="InterPro:IPR001196" /db_xref="InterPro:IPR005749" /db_xref="InterPro:IPR021131" /db_xref="InterPro:IPR030878" /db_xref="InterPro:IPR036227" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10444" /db_xref="UniProtKB/Swiss-Prot:P19946" /translation="MKLHELKPSEGSRKTRNRVGRGIGSGNGKTAGKGHKGQNARSGG GVRPGFEGGQMPLFQRLPKRGFTNINRKEYAVVNLDKLNGFAEGTEVTPELLLETGVI SKLNAGVKILGNGKLEKKLTVKANKFSASAKEAVEAAGGTAEVI*" /label="rplO CDS" gene 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /label="rplO gene" CDS 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478; Product type t: transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_388017.1" /db_xref="EnsemblGenomes-Gn:BSU01360" /db_xref="EnsemblGenomes-Tr:CAB11912" /db_xref="GOA:P16336" /db_xref="InterPro:IPR002208" /db_xref="InterPro:IPR023201" /db_xref="InterPro:IPR026593" /db_xref="InterPro:IPR030659" /db_xref="SubtiList:BG10445" /db_xref="UniProtKB/Swiss-Prot:P16336" /translation="MFKTISNFMRVSDIRNKIIFTLLMLIVFRIGAFIPVPYVNAEAL QAQSQMGVFDLLNTFGGGALYQFSIFAMGITPYITASIIIQLLQMDVVPKFTEWSKQG EVGRRKLAQFTRYFTIVLGFIQALGMSYGFNNLANGMLIEKSGVSTYLIIALVLTGGT AFLMWLGEQITSHGVGNGISIIIFAGIVSSIPKTIGQIYETQFVGSNDQLFIHIVKVA LLVIAILAVIVGVIFIQQAVRKIAIQYAKGTGRSPAGGGQSTHLPLKVNPAGVIPVIF AVAFLITPRTIASFFGTNDVTKWIQNNFDNTHPVGMAIYVALIIAFTYFYAFVQVNPE QMADNLKKQGGYIPGVRPGKMTQDRITSILYRLTFVGSIFLAVISILPIFFIQFAGLP QSAQIGGTSLLIVVGVALETMKQLESQLVKRNYRGFMKN*" /label="secY CDS" gene 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /label="secY gene" CDS 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /EC_number="2.7.4.3" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8061005, 8288548, 9056261, 9715904, 11106368, 16452168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8061005, 8288548, 9056261, 9715904, 11106368, 16452168; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate kinase" /protein_id="NP_388018.1" /db_xref="EnsemblGenomes-Gn:BSU01370" /db_xref="EnsemblGenomes-Tr:CAB11913" /db_xref="GOA:P16304" /db_xref="InterPro:IPR000850" /db_xref="InterPro:IPR006259" /db_xref="InterPro:IPR007862" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033690" /db_xref="PDB:1P3J" /db_xref="PDB:2EU8" /db_xref="PDB:2OO7" /db_xref="PDB:2ORI" /db_xref="PDB:2OSB" /db_xref="PDB:2P3S" /db_xref="PDB:2QAJ" /db_xref="PDB:3DKV" /db_xref="PDB:3DL0" /db_xref="PDB:4MKF" /db_xref="PDB:4MKG" /db_xref="PDB:4MKH" /db_xref="PDB:4QBF" /db_xref="PDB:4QBG" /db_xref="PDB:4TYP" /db_xref="PDB:4TYQ" /db_xref="SubtiList:BG10446" /db_xref="UniProtKB/Swiss-Prot:P16304" /translation="MNLVLMGLPGAGKGTQGERIVEDYGIPHISTGDMFRAAMKEETP LGLEAKSYIDKGELVPDEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEE YGKPIDYVINIEVDKDVLMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQR ADDNEETVSKRLEVNMKQTQPLLDFYSEKGYLANVNGQQDIQDVYADVKDLLGGLKK* " /label="adk CDS" gene 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /label="adk gene" CDS 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16207374, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase" /protein_id="NP_388019.1" /db_xref="EnsemblGenomes-Gn:BSU01380" /db_xref="EnsemblGenomes-Tr:CAB11914" /db_xref="GOA:P19994" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG10447" /db_xref="UniProtKB/Swiss-Prot:P19994" /translation="MIICKTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIA ERFIKKQGAIPSFKGYNGFRGSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGY HGDSAWTYPVGNISDDDKKLLEVTEESLYKGLQEAKPGERLSNISHAIQTYVENEQFS VVREYVGHGVGQDLHEDPQIPHYGPPNKGPRLKPGMVLAIEPMVNAGSRYVKTLADNW TVVTVDGKKCAHFEHTIAITETGFDILTRV*" /label="mapA CDS" gene 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /label="mapA gene" CDS 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17157877; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative ribosome binding protein" /protein_id="YP_003097669.1" /db_xref="EnsemblGenomes-Gn:BSU01389" /db_xref="EnsemblGenomes-Tr:CAX52539" /db_xref="UniProtKB/Swiss-Prot:C0H3S8" /translation="MIGQKAWVNIGKTEFILLLVVGILTIINVLTADGEKRTFHSPKK KNINHLTLYDCVSPEVQNSINETGRVTNFF*" /label="ybzG CDS" gene 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /label="ybzG gene" CDS 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9868784, 20477873, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-I" /protein_id="NP_388020.1" /db_xref="EnsemblGenomes-Gn:BSU01390" /db_xref="EnsemblGenomes-Tr:CAB11915" /db_xref="GOA:P20458" /db_xref="InterPro:IPR004368" /db_xref="InterPro:IPR006196" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11043" /db_xref="UniProtKB/Swiss-Prot:P20458" /translation="MAKDDVIEVEGTIVETLPNAMFKVELENGHTVLAHVSGKIRMHF IRILPGDKVTVELSPYDLTRGRITYRYK*" /label="infA CDS" gene 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /label="infA gene" CDS 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1783905, 23002217, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1783905, 23002217, 24335279; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L36 (ribosomal protein B)" /protein_id="NP_388021.1" /db_xref="EnsemblGenomes-Gn:BSU01400" /db_xref="EnsemblGenomes-Tr:CAB11916" /db_xref="GOA:P20278" /db_xref="InterPro:IPR000473" /db_xref="InterPro:IPR035977" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11042" /db_xref="UniProtKB/Swiss-Prot:P20278" /translation="MKVRPSVKPICEKCKVIRRKGKVMVICENPKHKQKQG*" /label="rpmJ CDS" gene 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /label="rpmJ gene" CDS 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S13" /protein_id="NP_388022.2" /db_xref="EnsemblGenomes-Gn:BSU01410" /db_xref="EnsemblGenomes-Tr:CAB11917" /db_xref="GOA:P20282" /db_xref="InterPro:IPR001892" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR018269" /db_xref="InterPro:IPR019980" /db_xref="InterPro:IPR027437" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10730" /db_xref="UniProtKB/Swiss-Prot:P20282" /translation="MARIAGVDIPRDKRVVISLTYIFGIGRTTAQQVLKEAGVSEDTR VRDLTEEELGKIRDIIDKLKVEGDLRREVSLNIKRLIEIGSYRGIRHRRGLPVRGQNS KNNARTRKGPRRTVANKKK*" /label="rpsM CDS" gene 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /label="rpsM gene" CDS 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217780, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217780, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S11 (BS11)" /protein_id="NP_388023.1" /db_xref="EnsemblGenomes-Gn:BSU01420" /db_xref="EnsemblGenomes-Tr:CAB11918" /db_xref="GOA:P04969" /db_xref="InterPro:IPR001971" /db_xref="InterPro:IPR018102" /db_xref="InterPro:IPR019981" /db_xref="InterPro:IPR036967" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10731" /db_xref="UniProtKB/Swiss-Prot:P04969" /translation="MAAARKSNTRKRRVKKNIESGIAHIRSTFNNTIVTITDTHGNAI SWSSAGALGFRGSRKSTPFAAQMAAETAAKGSIEHGLKTLEVTVKGPGSGREAAIRAL QAAGLEVTAIRDVTPVPHNGCRPPKRRRV*" /label="rpsK CDS" gene 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /label="rpsK gene" S_feature 148346..148521 /Source="Nicolas_S_feature" /locus_tag="new_148755_148930" /HighExp="G135, dia5, Lbexp, S0, aero, dia0, T-4.40H, G150, Paraq, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S56" CDS 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1484484, 6811591, 9594570, 10972808, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1484484, 6811591, 9594570, 10972808, 12682299, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (alpha subunit)" /protein_id="NP_388024.1" /db_xref="EnsemblGenomes-Gn:BSU01430" /db_xref="EnsemblGenomes-Tr:CAB11919" /db_xref="GOA:P20429" /db_xref="InterPro:IPR011260" /db_xref="InterPro:IPR011262" /db_xref="InterPro:IPR011263" /db_xref="InterPro:IPR011773" /db_xref="InterPro:IPR036603" /db_xref="InterPro:IPR036643" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG10732" /db_xref="UniProtKB/Swiss-Prot:P20429" /translation="MIEIEKPKIETVEISDDAKFGKFVVEPLERGYGTTLGNSLRRIL LSSLPGAAVTSIQIDGVLHEFSTIEGVVEDVTTIILHIKKLALKIYSDEEKTLEIDVQ GEGTVTAADITHDSDVEILNPDLHIATLGENASFRVRLTAQRGRGYTPADANKRDDQP IGVIPIDSIYTPVSRVSYQVENTRVGQVANYDKLTLDVWTDGSTGPKEAIALGSKILT EHLNIFVGLTDEAQHAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQE LANKTEEDMMKVRNLGRKSLEEVKAKLEELGLGLRKDD*" /label="rpoA CDS" gene 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /label="rpoA gene" CDS 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6801428, 10717392, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6801428, 10717392, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L17 (BL15)" /protein_id="NP_388025.1" /db_xref="EnsemblGenomes-Gn:BSU01440" /db_xref="EnsemblGenomes-Tr:CAB11920" /db_xref="GOA:P20277" /db_xref="InterPro:IPR000456" /db_xref="InterPro:IPR036373" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11041" /db_xref="UniProtKB/Swiss-Prot:P20277" /translation="MSYRKLGRTSAQRKAMLRDLTTDLIINERIETTETRAKELRSVV EKMITLGKRGDLHARRQAAAYIRNEVANEENNQDALQKLFSDIATRYEERQGGYTRIM KLGPRRGDGAPMAIIELV*" /label="rplQ CDS" gene 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /label="rplQ gene" downshifts 149908 /Source="Nicolas_upshifts" /id="D52" /incds=0 /nref=171 /ntot=259 /MaxReadThrough="7.50771" /MaxDrop="5.4374" /score="2.32634618" /energy="-10.5" /TU="U98" /idTUdmin="U98" /TUdmin="-5577" /isTUend="FALSE" /label="downshifts" S_feature 149953..150033 /Source="Nicolas_S_feature" /locus_tag="new_150362_150442" /HighExp="Cold, G180, G135, G150, H2O2, S0, C30, Oxctl, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S57" CDS 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388026.2" /db_xref="EnsemblGenomes-Gn:BSU01450" /db_xref="EnsemblGenomes-Tr:CAB11921" /db_xref="GOA:P40735" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030947" /db_xref="SubtiList:BG11067" /db_xref="UniProtKB/Swiss-Prot:P40735" /translation="MNQNQLISVEDIVFRYRKDAERRALDGVSLQVYEGEWLAIVGHN GSGKSTLARALNGLILPESGDIEVAGIQLTEESVWEVRKKIGMVFQNPDNQFVGTTVR DDVAFGLENNGVPREEMIERVDWAVKQVNMQDFLDQEPHHLSGGQKQRVAIAGVIAAR PDIIILDEATSMLDPIGREEVLETVRHLKEQGMATVISITHDLNEAAKADRIIVMNGG KKYAEGPPEEIFKLNKELVRIGLDLPFSFQLSQLLRENGLALEENHLTQEGLVKELWT LQSKM*" /label="ecfA CDS" gene 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /label="ecfA gene" CDS 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12110480, 21135102, 26052893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388027.1" /db_xref="EnsemblGenomes-Gn:BSU01460" /db_xref="EnsemblGenomes-Tr:CAB11922" /db_xref="GOA:P70970" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030946" /db_xref="SubtiList:BG11989" /db_xref="UniProtKB/Swiss-Prot:P70970" /translation="MKTPFERLALYDINASIKEGSYVAVIGHTGSGKSTLLQHLNGLL KPTKGQISLGSTVIQAGKKNKDLKKLRKKVGIVFQFPEHQLFEETVLKDISFGPMNFG VKKEDAEQKAREMLQLVGLSEELLDRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPT AGLDPRGRKEIMDMFYELHQRGNLTTILVTHSMEDAAAYADEMIVMHKGTIQASGSPR DLFLKGEEMAGWGLDLPETIKFQRHLEAALGVRFNEPMLTIEDAAAEIRALFQGEKTL *" /label="ecfAB CDS" gene 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /label="ecfAB gene" CDS 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18931129, 21135102, 26052893; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the influx ECF transporters" /protein_id="NP_388028.2" /db_xref="EnsemblGenomes-Gn:BSU01470" /db_xref="EnsemblGenomes-Tr:CAB11923" /db_xref="GOA:P70972" /db_xref="InterPro:IPR003339" /db_xref="InterPro:IPR024919" /db_xref="SubtiList:BG11990" /db_xref="UniProtKB/Swiss-Prot:P70972" /translation="MMDSMIIGKYVPGTSLVHRLDPRTKLITIFLFVCIVFLANNVQT YALLGLFTIGVVSLTRVPFSFLMKGLKPIIWIVLFTFLLHILMTHEGPIIFQIGFFKV YEGGLVQGIFISLRFVYLILITTLLTLTTTPIEITDGMEQLLNPLKKLKLPVHELALM MSISLRFIPTLMEETDKIMKAQMARGVDFTSGPVKERVKAIVPLLVPLFVSAFKRAEE LAVAMEARGYQGGEGRTKYRKLVWTGKDTSVIVSLIVLAALLFFLRA*" /label="ecfT CDS" gene 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /label="ecfT gene" CDS 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /EC_number="5.4.99.12" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10529181, 15353568, 17114947, 17466622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine (38-40) synthase" /protein_id="NP_388029.2" /db_xref="EnsemblGenomes-Gn:BSU01480" /db_xref="EnsemblGenomes-Tr:CAB11924" /db_xref="GOA:P70973" /db_xref="InterPro:IPR001406" /db_xref="InterPro:IPR020095" /db_xref="InterPro:IPR020097" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG11992" /db_xref="UniProtKB/Swiss-Prot:P70973" /translation="MRLKCTISYDGHLFNGYQVQPGKRTVQDELEKALAVLHKSKDRI PVVSSGRTDSGVHAAGQVIHFDTPLSIPAERWPYALNALLPDDIAVKQAEIADDGFHA RFSAVKKEYRYFVYTEKHPDVFKRHYAYHFSYRLNVQDMREAAKHLIGTHDFTSFCAA KTEVQDKVRTIYELDWTETADGLQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVK SMLEAKDREAAGRTAPGHGLYLWNVYYDN*" /label="truA CDS" gene 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /label="truA gene" S_feature complement(152630..153098) /Source="Nicolas_S_feature" /locus_tag="new_153039_153507_c" /HighExp="S6, S8, S7, C30, G135, BT, S5, C90, M/G, Pyr" /AntisenseName="truA" /AntisenseCor="-0.30232258010971202" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S58" promotor_-35 152763..152768 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 152783..152800 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 152802 /Source="Nicolas_upshifts" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(153098..153117) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(153120) /Source="Nicolas_upshifts" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(153130..153139) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 153291..153297 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153312..153331 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153316 /Source="Nicolas_upshifts" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /product="putative L13_leader" /note="Evidence 3: Putative function from multiple computational evidences; Product type n: RNA" /label="ldlM RNA" gene 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /label="ldlM gene" CDS 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 23504016, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 23504016, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L13" /protein_id="NP_388030.2" /db_xref="EnsemblGenomes-Gn:BSU01490" /db_xref="EnsemblGenomes-Tr:CAB11925" /db_xref="GOA:P70974" /db_xref="InterPro:IPR005822" /db_xref="InterPro:IPR005823" /db_xref="InterPro:IPR023563" /db_xref="InterPro:IPR036899" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11970" /db_xref="UniProtKB/Swiss-Prot:P70974" /translation="MRTTPMANASTIERKWLVVDAAGKTLGRLSSEVAAILRGKHKPT YTPHVDTGDHVIIINAEKIELTGKKLTDKIYYRHTQHPGGLKSRTALEMRTNYPEKML ELAIKGMLPKGSLGRQMFKKLNVYRGSEHPHEAQKPEVYELRG*" /label="rplM CDS" gene 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /label="rplM gene" CDS 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 19653700, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S9" /protein_id="NP_388031.1" /db_xref="EnsemblGenomes-Gn:BSU01500" /db_xref="EnsemblGenomes-Tr:CAB11926" /db_xref="GOA:P21470" /db_xref="InterPro:IPR000754" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020574" /db_xref="InterPro:IPR023035" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19007" /db_xref="UniProtKB/Swiss-Prot:P21470" /translation="MAQVQYYGTGRRKSSVARVRLVPGEGRIVVNNREISEHIPSAAL IEDIKQPLTLTETAGTYDVLVNVHGGGLSGQAGAIRHGIARALLEADPEYRTTLKRAG LLTRDARMKERKKYGLKGARRAPQFSKR*" /label="rpsI CDS" gene 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /label="rpsI gene" downshifts 154258 /Source="Nicolas_upshifts" /id="D53" /incds=0 /nref=262 /ntot=282 /MaxReadThrough="4.65387" /MaxDrop="8.11906" /score="30.5093496" /energy="-13.3" /TU="U98,U100,U102" /idTUdmin="U98" /TUdmin="-1227" /isTUend="FALSE" /label="downshifts" promotor_-35 154400..154407 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 154421..154440 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 154429..154710 /Source="Nicolas_S_feature" /locus_tag="new_154838_155119" /HighExp="H2O2, G180, G135, Paraq, Diami, dia15, Oxctl, Cold, Heat, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.479, 1" /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S59" upshifts 154429 /Source="Nicolas_upshifts" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature 154709..154728 /Source="Nicolas_upshift_promotors" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 154712 /Source="Nicolas_upshifts" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26582911; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388032.2" /db_xref="EnsemblGenomes-Gn:BSU01510" /db_xref="EnsemblGenomes-Tr:CAB11927" /db_xref="GOA:P70976" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11994" /db_xref="UniProtKB/Swiss-Prot:P70976" /translation="MNALVAHNSKAWDKKVETGNEWTVAVEQQVIEQAKKGNWDIRVT PMKDVPKDWFPPIKGLKVLCLASGGGQQGPVLAAAGADVTVLDNSEKQLNQDRMIAER DGLTIHTVKGSMDDLSVFNDESFDVIVHPVANVFVENVLPVWKEAYRVLKRNGILISG FVNPVVFLFDTELEQQGVLKVKHSIPYADPEDLPKHKVKKLIENNEALEFGHSLEDQI KGQIDAGFIVTGFYEDKGGFVLDQYIHTYSATRSVKV*" /label="ybaJ CDS" gene 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /label="ybaJ gene" downshifts 155505 /Source="Nicolas_upshifts" /id="D54" /incds=0 /nref=215 /ntot=251 /MaxReadThrough="2.69346" /MaxDrop="6.09641" /score="4.42269359" /energy="-10.3" /TU="NA" /idTUdmin="U100" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 155644..155650 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 155665..155676 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 155672 /Source="Nicolas_upshifts" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679227, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388033.1" /db_xref="EnsemblGenomes-Gn:BSU01520" /db_xref="EnsemblGenomes-Tr:CAB11928" /db_xref="GOA:P50862" /db_xref="InterPro:IPR019667" /db_xref="SubtiList:BG11503" /db_xref="UniProtKB/Swiss-Prot:P50862" /translation="MAEVLSFMDVKRQKDFELEKNLLKELSLRQIIQSVKDCLEPLFP FLHDERDIITEGCIDFAIEAYLLGGRFGIFGYYGESMQSISARSAREEEELRMEFFDY LYNWIHEQYATFDKNTVYEAARKFIKDWWTAGFVQREKQCKLRMR*" /label="ybaK CDS" gene 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /label="ybaK gene" promotor_-35 156143..156148 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156164..156182 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156165 /Source="Nicolas_upshifts" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /EC_number="3.5.1.28" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_388034.1" /db_xref="EnsemblGenomes-Gn:BSU01530" /db_xref="EnsemblGenomes-Tr:CAB11929" /db_xref="GOA:P50864" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR014234" /db_xref="SubtiList:BG11514" /db_xref="UniProtKB/Swiss-Prot:P50864" /translation="MRKKLKWLSFLLGFIILLFLFKYQFSNNDSWKPWSLPLSGKIIY LDPGHGGPDGGAVGGKLLEKDVTLEVAFRVRDYLQEQGALVIMTRESDTDLAPEGTKG YSRRKAEDLRQRVKLINHSEAELYISIHLNAIPSQKWSGAQSFYYGKYAENEKVAKYI QDELRRNLENTTRKAKRIHGIYLMQNVTKPGALIEVGFLSNPSEATLLGKPKYQDKVA SSIYKGILRYFTEKGDPPE*" /label="cwlD CDS" gene 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /label="cwlD gene" upshifts 156961 /Source="Nicolas_upshifts" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="upshifts" misc_feature 156964..156983 /Source="Nicolas_upshift_promotors" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11790741, 15126467, 26094643" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11790741, 15126467, 26094643; Product type r: regulator" /codon_start=1 /transl_table=11 /product="phosphorylation-dependent (Y327) transcriptionalregulator" /protein_id="NP_388035.1" /db_xref="EnsemblGenomes-Gn:BSU01540" /db_xref="EnsemblGenomes-Tr:CAB11930" /db_xref="GOA:P50863" /db_xref="InterPro:IPR000808" /db_xref="InterPro:IPR019591" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG11494" /db_xref="UniProtKB/Swiss-Prot:P50863" /translation="MIREDEVRKLVGEMREPFLQRPLGELDAVKEIKIKPEKRHISVK VALAKTGTAEQMQIQQEIVNVLKGAGAETVGLRFEELPEETVAKFRAPSAEKKTLLNM DNPPVFLAVASGKGGVGKSTVSVNLAISLARLGKKVGLIDADIYGFSVPDMMGITVRP TIEGEKLLPVERFGVKVMSMGFFVEENAPVVWRGPMLGKMLNNFFHEVEWGEVDYIVL DLPPGTGDVALDVHTMLPSCKEIIVSTPHPTAAFVAARAGSMAIKTDHEVVGVIENMA YYESAKTGEREYVFGKGGGDKLAEELNVPLLGRIPLKQPDWDKDQFAPSVYDENHPIG EIYQDIAKKIDAKMSVQV*" /label="salA CDS" gene 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /label="salA gene" S_feature complement(157641..158105) /Source="Nicolas_S_feature" /locus_tag="new_158050_158514_c" /HighExp="S8, S7, S6, S5, C30, S4, C90, nit, ferm, Gly" /AntisenseName="salA" /AntisenseCor="-0.104183954485248" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S60" downshifts 158056 /Source="Nicolas_upshifts" /id="D55" /incds=0 /nref=29 /ntot=155 /MaxReadThrough="5.44939" /MaxDrop="4.18382" /score="-4.46878413" /energy="-9.1" /TU="U107" /idTUdmin="U106" /TUdmin=1185 /isTUend="FALSE" /label="downshifts" S_feature 158101..158772 /Source="Nicolas_S_feature" /locus_tag="new_158510_159181" /HighExp="Lbtran, H2O2, Cold, Lbstat, dia5, M40t45, M0t90, M40t90, T0.30H, S1" /AntisenseName="gerD" /AntisenseCor="-0.24235509346425901" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S61" CDS complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17122337, 10618233, 10376819, 24530795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17122337, 10618233, 10376819, 24530795; Product type f: factor" /codon_start=1 /transl_table=11 /product="lipoprotein factor mediating clustering of germination proteins" /protein_id="NP_388036.1" /db_xref="EnsemblGenomes-Gn:BSU01550" /db_xref="EnsemblGenomes-Tr:CAB11931" /db_xref="GOA:P16450" /db_xref="SubtiList:BG10644" /db_xref="UniProtKB/Swiss-Prot:P16450" /translation="MSKAKTLLMSCFLLLSVTACAPKDQAADMDYDQTKKMVVDILKT DDGKKAIKELLNDDAMNEALVIDQDAIKGTIEKTLTSKKGEEFWKNIFEDTDFAEGFA KTLQTEHEKVIKKLMKDPDYQKMLMSVMQDPGMDKKYSQLAKSQEFRSYLEEVINETL SSPLYKKQFEDELKKAAKDTAKESE*" /label="gerD CDS" gene complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /label="gerD gene" promotor_-10 complement(158695..158706) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(158707) /Source="Nicolas_upshifts" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(158720..158726) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(158740..159369) /Source="Nicolas_S_feature" /locus_tag="new_159149_159778_c" /HighExp="S3, T5.0H, S4, S8, M9-stat, T4.0H, T3.30H, S7, T3.0H, S6" /AntisenseName="kbaA" /AntisenseCor="7.9344921760152495E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S62" CDS 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8576055, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576055, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inner membrane protein involved in activation ofthe KinB signaling pathway to sporulation" /protein_id="NP_388037.1" /db_xref="EnsemblGenomes-Gn:BSU01560" /db_xref="EnsemblGenomes-Tr:CAB11932" /db_xref="GOA:P16449" /db_xref="InterPro:IPR024164" /db_xref="SubtiList:BG10643" /db_xref="UniProtKB/Swiss-Prot:P16449" /translation="MKSRGLVRFFFSILAVGALITSIVGFALKWGEYRGLFLTFEAGQ IFSVLFWFIGVGMIFSVISQMGFFVFLTVHRFALEILRSSSLWNLLQLFFILFVAFDL MYVRFLFFGESGESLAGYAWLPVFLLIFGVITAYIKQKQSSKKTFVSSLFLMVVITAL EWFPALRVNDEDWLYLMLFPLMACNAFQLLMLPKFAAK*" /label="kbaA CDS" gene 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /label="kbaA gene" S_feature 159370..160264 /Source="Nicolas_S_feature" /locus_tag="new_159779_160673" /HighExp="Lbstat, Lbtran, M0t90, M40t90, H2O2, BC, Glucon, S7, M40t45, S1" /AntisenseName="ybaN" /AntisenseCor="-2.6735901031407501E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S63" CDS complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 15598884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 15598884; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="polysaccharide deacetylase involved in sporulation" /protein_id="NP_388038.1" /db_xref="EnsemblGenomes-Gn:BSU01570" /db_xref="EnsemblGenomes-Tr:CAB11933" /db_xref="GOA:P50865" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014132" /db_xref="SubtiList:BG11416" /db_xref="UniProtKB/Swiss-Prot:P50865" /translation="MNHFYVWHIKRVKQLIIILIAAFAAASFFYIQRAVPLPVFSTDT GPKAIYKGETDSKDISLTFDISWGDERAEPILNTLKANGIKNATFFLSASWAERHPDT VARIVKDGHQIGSMGYAYKNYANLESSEIKKDMNRAQTAFEKLGVKDIQLLRPPTGQF NKNVLKVAKQYNYTVVHYSVNSQDWTNPGVEKIIDNVTKQVSGGDIILLHASDSAKQT EEALPDIIHQLKEKGLKNVTVGDLIANSDAKSAEVK*" /label="pdaB CDS" gene complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /label="pdaB gene" promotor_-10 complement(160165..160183) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(160185) /Source="Nicolas_upshifts" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(160199..160204) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 160242..160249 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 160264..160283 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 160266..160483 /Source="Nicolas_S_feature" /locus_tag="new_160675_160892" /HighExp="Diami, LBGstat, UNK1, H2O2, MG 15, Oxctl, MG-0.1, BMM, T-1.10H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S64" upshifts 160266 /Source="Nicolas_upshifts" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-16S rRNA" gene 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /modified_by="User" /label="rrnI-16S gene" Polymorphism join(160830,160832) /Source="geneious" /ID="SNP_BsDelta6_161240_161239" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=45 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value="4.2e-57" /Variant_Raw_Frequency=41 /comment="rrnI-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-23S rRNA" gene 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /label="rrnI-23S gene" rRNA 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /product="ribosomal RNA-5S" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-5S rRNA" gene 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /label="rrnI-5S gene" Polymorphism join(165341,165342) /Source="geneious" /ID="SNP_BsDelta6_165748_165749" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="-TC" /Codon_Change /Coverage="172 -> 174" /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TC" /Variant_Nucleotides /Variant_P_Value="1.5e-307" /Variant_Raw_Frequency=152 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(165342,165344) /Source="geneious" /ID="SNP_BsDelta6_165751_165751" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="C -> T" /Codon_Change /Coverage=172 /locus_tag /Protein_Effect /Reference_Frequency="1.2%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=168 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Asn tRNA" gene 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /label="trnI-Asn gene" Polymorphism join(165417,165419) /Source="geneious" /ID="SNP_BsDelta6_165826_165825" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=163 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=160 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(GGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Thr tRNA" gene 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /label="trnI-Thr gene" tRNA 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Gly tRNA" gene 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /label="trnI-Gly gene" Polymorphism join(165630,165632) /Source="geneious" /ID="SNP_BsDelta6_166038_166037" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="T" /Codon_Change /Coverage=154 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=148 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg(AGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Arg tRNA" gene 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /label="trnI-Arg gene" tRNA 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Pro tRNA" gene 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /label="trnI-Pro gene" tRNA 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Ala tRNA" gene 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /label="trnI-Ala gene" Polymorphism join(165937,165938) /Source="geneious" /ID="SNP_BsDelta6_166344_166344" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-G" /Codon_Change /Coverage=132 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides /Variant_P_Value="4.9e-75" /Variant_Raw_Frequency=130 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-16S rRNA" gene 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /label="rrnH-16S gene" rRNA 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-23S rRNA" gene 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /label="rrnH-23S gene" rRNA 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-5S rRNA" gene 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /label="rrnH-5S gene" rRNA 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-16S rRNA" gene 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /label="rrnG-16S gene" rRNA 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-23S rRNA" gene 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /label="rrnG-23S gene" rRNA 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-5S rRNA" gene 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /label="rrnG-5S gene" S_feature 175915..176523 /Source="Nicolas_S_feature" /locus_tag="new_176316_176924" /HighExp="G180, G135, C30, Oxctl, Paraq, Cold, G150, H2O2, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S65" promotor_-35 176491..176495 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 176511..176530 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 176525..176681 /Source="Nicolas_S_feature" /locus_tag="new_176926_177082" /HighExp="LBGstat, G180, G135, dia15, C30, Oxctl, LPhT, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S66" upshifts 176525 /Source="Nicolas_upshifts" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="upshifts" CDS 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388039.1" /db_xref="EnsemblGenomes-Gn:BSU01580" /db_xref="EnsemblGenomes-Tr:CAB11934" /db_xref="GOA:P55189" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR018045" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11562" /db_xref="UniProtKB/Swiss-Prot:P55189" /translation="MNNSFTLKQQWFGNIRKDILAGILVALALIPEAIGFSIIAGVDP MVGLYASFCIAIIISIFGGRPGMISAATGSMAVVMVSLVADHGLQYLFAATILTGIIQ VILGISKIARLMKFIPRSVMIGFVNALAILIFSAQLPQFEGASWSMYAMLAGSLVIIY VLPRFTTAVPSPLVAIIVMTIIAVTFHVDVRTVGDMGNISSSLPHFLIPDVPFTFETL QIIFPYSIALAFVGLLESLLTAQIIDEMTDTDSDKNKESRGQGIANIVTGFFGGMAGC AMIGQSVINTKAGGRGRLSAFVAGAFLMFLIAVLSHVVVKIPMAALVAVMVMVSVGTF DWSSLKGLKKAPLTDSIVMVVTVVTVVVTDDLSKGVFVGVLLSAVFFVAKISKLKIVS HAEDQKLRTYQVKGQIFFASVTDLTNAFIYQEDIERVVIDLTEAHVWDDSGAAALDKI VAKFKEQGIEAELKGLNKASKSLMKQMA*" /label="ybaR CDS" gene 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /label="ybaR gene" downshifts 178107 /Source="Nicolas_upshifts" /id="D56" /incds=0 /nref=144 /ntot=228 /MaxReadThrough="2.81758" /MaxDrop="4.71162" /score="18.4600501" /energy="-12" /TU="NA" /idTUdmin="U111" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 178161..178166 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 178179..178198 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 178197 /Source="Nicolas_upshifts" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="upshifts" CDS 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium dependent transporter" /protein_id="NP_388040.2" /db_xref="EnsemblGenomes-Gn:BSU01590" /db_xref="EnsemblGenomes-Tr:CAB11935" /db_xref="GOA:P55190" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG11563" /db_xref="UniProtKB/Swiss-Prot:P55190" /translation="MPLLTPTSVVLGVLLSQFLNGYEWAVPWIFAFITFAGSLSANFQ SLRHALSHPLPMILALFVLHIFMPLFAWGSGHLIFKGDPLTITGLTLAVVIPTGITSL IWAAMYKGNVGLTLSIILVDTVLSPLIVPLSLSLLAGAQVHMDVWGMMKGLIVMVVIP SFLGMLFNQMSSPERTAFVSSALSPFSKLCLMAVIAINSSAIAPYFKSIDLRFAGIAV TVFFIALTGYAAAWLIGKMMKRRQEEIVSLIFTGGMRNISAGAVLAVTFFPSQVAVPV VIGMLFQQILAALFGYMLNRFELKPMLQKA*" /label="ybaS CDS" gene 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /label="ybaS gene" downshifts 179165 /Source="Nicolas_upshifts" /id="D57" /incds=0 /nref=33 /ntot=224 /MaxReadThrough="1.3063" /MaxDrop="3.58628" /score="13.3102824" /energy="-10.5" /TU="NA" /idTUdmin="U112" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 2974033, 17725565, 22210890, 28283524" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 2974033, 17725565, 22210890, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-chelator (enterobactin family) esterase" /protein_id="NP_388041.2" /db_xref="EnsemblGenomes-Gn:BSU01600" /db_xref="EnsemblGenomes-Tr:CAB11936" /db_xref="GOA:P55192" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11565" /db_xref="UniProtKB/Swiss-Prot:P55192" /translation="MKGSLSEHKAGNRRFTLYLPPSYSTDSGGFPAVYVQDGSSLFQN QIELLESAFQQQRLPELVLIGIEPENRLDEYTPWPAASLSDRFTDFGGMGYHYLSDIT NQFIPLIEENWNVTREPQSRGMIGASLGGLISMFAILKYPSMFGKIGSISGSYWYENA AETIHISSLKPGTARVFMSIGSEEGREKQSIQRHMLKKTKQVHQSLKEKGFTEDQLCL SIEKGAVHHHKYFCKQFINALEWLYGKNRSTL*" /label="eesA CDS" gene complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /label="eesA gene" downshifts complement(179218) /Source="Nicolas_upshifts" /id="D58" /incds=0 /nref=15 /ntot=115 /MaxReadThrough="0.3819" /MaxDrop="4.57603" /score="25.9728338" /energy="-10.5" /TU="NA" /idTUdmin="U114" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2651410, 15849754, 16850406, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-uptake protein" /protein_id="NP_388042.2" /db_xref="EnsemblGenomes-Gn:BSU01610" /db_xref="EnsemblGenomes-Tr:CAB11937" /db_xref="GOA:P40411" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10837" /db_xref="UniProtKB/Swiss-Prot:P40411" /translation="MAKKYALFIALILVVSYFSLTSGSFSVRPAELLSTLFQIDPNPQ YEILLFDLRLPRVVMAAIIGLGLGIAGAVIQAITRNGLADPGILGINAGAGAGIVAFM LLFQGQKEVTSIAAAMGMPLFGLIGGLIAAILIYIFAWHRGNLDSGRIILVGIAINSG FSALSLFLSLKMDPQDYQMAMVWKNGSIWSANWTYITAVLPWMLLFIPILIGKSRLLD TIRFDEDTVRSLGISSNKEKTILLVACVAIISACVSVAGSMAFVGLIAPHISRRLAGV EHRYILPLSGLIGMLLVISADFAGKLFFQPAEVPAGIILAILGVPYFLYLLFKQKKGE NA*" /label="feuC CDS" gene complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /label="feuC gene" CDS complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2651410, 15849754, 16850406, 17725565; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin permease" /protein_id="NP_388043.1" /db_xref="EnsemblGenomes-Gn:BSU01620" /db_xref="EnsemblGenomes-Tr:CAB11938" /db_xref="GOA:P40410" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10836" /db_xref="UniProtKB/Swiss-Prot:P40410" /translation="MYSKQWTRIILITSPFAIALSLLLSILYGAKHLSTDIVFTSLIH FDPGNTDHQIIWHSRIPRAAGALLIGAALAVSGALMQGITRNYLASPSIMGVSDGSAF IITLCMVLLPQSSSIEMMIYSFIGSALGAVLVFGLAAMMPNGFTPVQLAIIGTVTSML LSSLSAAMSIYFQISQDLSFWYSARLHQMSPDFLKLAAPFFLIGIIMAISLSKKVTAV SLGDDISKSLGQKKKTIKIMAMLSVIILTGSAVALAGKIAFVGLVVPHITRFLVGSDY SRLIPCSCILGGIFLTLCDLASRFINYPFETPIEVVTSIIGVPFFLYLIKRKGGEQNG *" /label="feuB CDS" gene complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /label="feuB gene" CDS complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8388528, 16889643, 17725565, 21802011, 22303020, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8388528, 16889643, 17725565, 21802011, 22303020, 25355936; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin-binding lipoprotein" /protein_id="NP_388044.1" /db_xref="EnsemblGenomes-Gn:BSU01630" /db_xref="EnsemblGenomes-Tr:CAB11939" /db_xref="GOA:P40409" /db_xref="InterPro:IPR002491" /db_xref="PDB:2PHZ" /db_xref="PDB:2WHY" /db_xref="PDB:2WI8" /db_xref="PDB:2XUZ" /db_xref="PDB:2XV1" /db_xref="SubtiList:BG10835" /db_xref="UniProtKB/Swiss-Prot:P40409" /translation="MKKISLTLLILLLALTAAACGSKNESTASKASGTASEKKKIEYL DKTYEVTVPTDKIAITGSVESMEDAKLLDVHPQGAISFSGKFPDMFKDITDKAEPTGE KMEPNIEKILEMKPDVILASTKFPEKTLQKISTAGTTIPVSHISSNWKENMMLLAQLT GKEKKAKKIIADYEQDLKEIKTKINDKAKDSKALVIRIRQGNIYIYPEQVYFNSTLYG DLGLKAPNEVKAAKAQELSSLEKLSEMNPDHIFVQFSDDENADKPDALKDLEKNPIWK SLKAVKEDHVYVNSVDPLAQGGTAWSKVRFLKAAAEKLTQN*" /label="feuA CDS" gene complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /label="feuA gene" promotor_-35 182282..182288 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 182303..182321 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 182312 /Source="Nicolas_upshifts" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(182953..182972) /Source="Nicolas_upshift_promotors" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(182960) /Source="Nicolas_upshifts" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16889643, 17725565, 17962296, 22210890" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16889643, 17725565, 17962296, 22210890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AraC/XylS family) of synthesis and uptake of the siderophore bacillibactin" /protein_id="NP_388045.1" /db_xref="EnsemblGenomes-Gn:BSU01640" /db_xref="EnsemblGenomes-Tr:CAB11940" /db_xref="GOA:P40408" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG10834" /db_xref="UniProtKB/Swiss-Prot:P40408" /translation="MQNAVIYQPVQIEYLKKTSDLFSEQQLADSFVLIFHLKGNGYIS IGTNTNPLQKKTLYVCPPNETFGFTPAADGHIDACIIRLLSYIKETGQDIFTPCTESE LAKLKLMNVSHIENLAVRLQELAALWNESSQLSQLKCVIEVQSLIYDLFTASLSDQTD THSAIEKTKHYIETHADTKITLAQLSQMAGISAKHYSESFKKWTGQSVTEFITKTRIT KAKRLMAKSNCKLKEIAHQTGYQDEFYFSRIFKKYTGCSPTSYMKKRRKKIAAYGRGT MGHLIPLHHIPFAAALHPKWTSYYYQHYSTDIPVQLSAYRFNEKWEENLYTLSQAEPD VIVSMDSISPEEQDRLNRIAEVMYLPSEESWRTHFLQTASFLKEESEAEKWLADYDQQ TTAAKKTLQHVQGLRFLFLRLHKQNFYLAHNRSVREVFFGDLGFSSATTADTPSEQAI SLENIANYQADCMMLFLFKEPETIAYYQQLQQTEAWQNLSAVRDNRVYLLSLDPWNEY SACGHERIVQQTVSLLSGDCP*" /label="btr CDS" gene complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /label="btr gene" promotor_-10 complement(184643..184662) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(184655) /Source="Nicolas_upshifts" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(184677..184684) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(184764) /Source="Nicolas_upshifts" /id="D59" /incds=0 /nref=19 /ntot=58 /MaxReadThrough="1.28464" /MaxDrop="7.13916" /score="9.64466628" /energy="-10.1" /TU="NA" /idTUdmin="U116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388046.1" /db_xref="EnsemblGenomes-Gn:BSU01650" /db_xref="EnsemblGenomes-Tr:CAB11941" /db_xref="InterPro:IPR008302" /db_xref="SubtiList:BG10833" /db_xref="UniProtKB/Swiss-Prot:P40407" /translation="MRKTIFAFLTGLMMFGTITAASASPDSKNQTAKKPKVQTGIDTL LPDYKKQLKGKRIGLITNPAGVNTSLKSSVDILYENPDIKLTALFGPEHGVRGDAQAG DEVGSYIDEKTGVPVYSLYGKTKKPTPEMLKNVDILMFDIQDVGTRFYTYIYTMAYAM EAAKENGIPFMVLDRPNPQGGNHIEGPILEPEYASFVGLYPIPLKHGMTIGELASLFN KEFSIDADLTVVKMKHWKRKMDFDDTRLPFVLPSPNMPTVESTFVYPATGLIEGTNIS EGRGTTKPFELIGAPFIKSTELEETLNSLHLPGVTFRAASFTPTFSKHQGTLCHGVQL YVTDRDKFEAVKTGLSVIKTIHDLYPEDFEFLSTGSFDKLAGNGWIRTKIENGTSVEN IINSYEKTLQQFSKTRKKYLIY*" /label="ybbC CDS" gene complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /label="ybbC gene" downshifts complement(184814) /Source="Nicolas_upshifts" /id="D60" /incds=0 /nref=11 /ntot=122 /MaxReadThrough="7.66074" /MaxDrop="4.10379" /score="9.64466628" /energy="-10.1" /TU="U116" /idTUdmin="U116" /TUdmin="-50" /isTUend="FALSE" /label="downshifts" CDS complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /EC_number="3.2.1.52" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8063094, 20400549, 20826810, 23177201, 26963691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8063094, 20400549, 20826810, 23177201, 26963691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosaminidase lipoprotein" /protein_id="NP_388047.1" /db_xref="EnsemblGenomes-Gn:BSU01660" /db_xref="EnsemblGenomes-Tr:CAB11942" /db_xref="GOA:P40406" /db_xref="InterPro:IPR001764" /db_xref="InterPro:IPR002772" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR019800" /db_xref="InterPro:IPR036881" /db_xref="InterPro:IPR036962" /db_xref="PDB:3BMX" /db_xref="PDB:3LK6" /db_xref="PDB:3NVD" /db_xref="PDB:4GYJ" /db_xref="PDB:4GYK" /db_xref="SubtiList:BG10832" /db_xref="UniProtKB/Swiss-Prot:P40406" /translation="MRPVFPLILSAVLFLSCFFGARQTEASASKRAIDANQIVNRMSL DEKLGQMLMPDFRNWQKEGESSPQALTKMNDEVASLVKKYQFGGIILFAENVKTTKQT VQLTDDYQKASPKIPLMLSIDQEGGIVTRLGEGTNFPGNMALGAARSRINAYQTGSII GKELSALGINTDFSPVVDINNNPDNPVIGVRSFSSNRELTSRLGLYTMKGLQRQDIAS ALKHFPGHGDTDVDSHYGLPLVSHGQERLREVELYPFQKAIDAGADMVMTAHVQFPAF DDTTYKSKLDGSDILVPATLSKKVMTGLLRQEMGFNGVIVTDALNMKAIADHFGQEEA VVMAVKAGVDIALMPASVTSLKEEQKFARVIQALKEAVKNGDIPEQQINNSVERIISL KIKRGMYPARNSDSTKEKIAKAKKIVGSKQHLKAEKKLAEKAVTVLKNEQHTLPFKPK KGSRILIVAPYEEQTASIEQTIHDLIKRKKIKPVSLSKMNFASQVFKTEHEKQVKEAD YIITGSYVVKNDPVVNDGVIDDTISDSSKWATVFPRAVMKAALQHNKPFVLMSLRNPY DAANFEEAKALIAVYGFKGYANGRYLQPNIPAGVMAIFGQAKPKGTLPVDIPSVTKPG NTLYPLGYGLNIKTGRPL*" /label="nagZ CDS" gene complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /label="nagZ gene" CDS complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16452451, 20400549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16452451, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidase hydrolyzing N-acetylmuramyl-L-Ala bond of MurNAc peptides" /protein_id="NP_388048.2" /db_xref="EnsemblGenomes-Gn:BSU01670" /db_xref="EnsemblGenomes-Tr:CAB11943" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR022849" /db_xref="SubtiList:BG11566" /db_xref="UniProtKB/Swiss-Prot:O05213" /translation="MKTKTLFIFSAILTLSIFAPNETFAQTAGNLIEPKIINAETAQF STKKLRKVDQMIERDIAAGFPGAVLVVVKDGRIIKKAAYGYSKKYEGSELLRRPAKMK TRTMFDLASNTKMYATNFALQRLVSQGKLDVYEKVSAYLPGFKDQPGDLIKGKDKIRV IDVLQHQSGLPSSFYFYTPEKAGKYYSQERDKTIEYLTKIPLDYQTGTKHVYSDIGYM LLGCIVEKLTGKPLDVYTEQELYKPLRLKHTLYNPLQKGFKPKQFAATERMGNTRDGV IQFPNIRTNTLQGEVHDEKAFYSMDGVSGHAGLFSNADDMAILLQVMLNKGSYRNISL FDQKTADLFTAPSATDPTFALGWRRNGSKSMEWMFGPHASENAYGHTGWTGTVTIIDP AYNLGIALLTNKKHTPVIDPEENPNVFEGDQFPTGSYGSVITAIYEAME*" /label="amiE CDS" gene complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /label="amiE gene" CDS complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /EC_number="2.7.1.192" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060041, 15849754, 16850406, 10627040, 20400549, 22960854; Product type t : transporter" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid PTS permease-MurP subunit" /protein_id="NP_388049.3" /db_xref="EnsemblGenomes-Gn:BSU01680" /db_xref="EnsemblGenomes-Tr:CAB11944" /db_xref="GOA:Q797S1" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11567" /db_xref="UniProtKB/Swiss-Prot:Q797S1" /translation="MSKENNYHHLAQKILELCGGKSNISSYTHCMTRLRITPYDESKA DAQALRKLDGVLGVVEAETLQIILGTGVVNHVTAAFSKLVSAEEGADVKEAAAKKKAD INRKNATPFKLFLRKIASIFIPLIPALVASGLITGITKAIIQAGWLSADSQIAIILTV IGSGLFTYLGILVGINASKEFGGTPALGALAGILIINPEIAKISLFGEELLPGRGGLI GVLFAAIFIAYTEQFIRRFIPQSLDIIVTPTVSLLITGIVTYVVFMPLGGFISDAITS GLLSILDIGGIAAGFILGATFLPLVVTGLHQGLTPVHMELINSIGNDPLLPILAMGGA GQVGAAFAVFVKTKKTTLRKAIAGGLPSGLLGIGEPLIFGVTLPLGRPFLTACLGAGI GGAFQAYFQVATIAIGVSGLPLSFLVLPSQIILYIVGLFISYAAGFLLTYAFGYKDEM ASQFD*" /label="murP CDS" gene complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /label="murP gene" CDS complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20400549; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator MurR-N-acetylmuramic acid" /protein_id="NP_388050.1" /db_xref="EnsemblGenomes-Gn:BSU01690" /db_xref="EnsemblGenomes-Tr:CAB11945" /db_xref="GOA:Q45581" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="PDB:2O3F" /db_xref="SubtiList:BG11569" /db_xref="UniProtKB/Swiss-Prot:Q45581" /translation="MATGGLAIIQSMKHKLPPSERKLADYILAHPHKAIESTVNEISA LANSSDAAVIRLCKSLGLKGFQDLKMRVAGDLAKPTFQGYRDIVPHEPLPSISEKTAG NAIQAIQDTSDLMDYKELERAVSLLLKAHTVHFIGLGASGIVAKDAQQKWLRIHKQAT AFTDTHLVASLIANADKDDIVFAISFSGETQEIVELFAMAKEKGITTISLTQFSQTSV SALADVPLYTAHSNEALIRSAATSSRLAQLFIIDVLFLGMAAEQYETTTGYIDKTRAA IQSMRIK*" /label="murR CDS" gene complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /label="murR gene" CDS complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /EC_number="4.2.1.126" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15983044, 20400549, 16452451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lactyl ether N-acetylmuramic-6-phosphate acid etherase" /protein_id="NP_388051.1" /db_xref="EnsemblGenomes-Gn:BSU01700" /db_xref="EnsemblGenomes-Tr:CAB11946" /db_xref="GOA:Q45582" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005486" /db_xref="InterPro:IPR005488" /db_xref="SubtiList:BG11570" /db_xref="UniProtKB/Swiss-Prot:Q45582" /translation="MSEPLNLHRLTTESRNSQTVEIHKANTLGILKMINNEDMKVAAA VQEVLPDIKTAVDCAYESFQNGGRLIYTGAGTSGRLGVMDAVECPPTYSVSPDQVIGI MAGGPEAFLQAAEGIEDSEEAGAEDLRNIQLTSNDTVIAIAASGRTPYAAGALRYARK VGAHTIALTCNENSAISKDADHSIEVVVGPEAITGSTRMKAATAHKMILNMISTAVMV KIGKVYENLMVDVNVSNKKLKERAISIIQSLTNASYDTARYTLEQADHHVKTAIVMLK TSTDQKQAQTLLDEANGFIDKAIEHYHP*" /label="murQ CDS" gene complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /label="murQ gene" promotor_-10 complement(192595..192613) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(192608) /Source="Nicolas_upshifts" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(192629..192636) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_388052.2" /db_xref="EnsemblGenomes-Gn:BSU01710" /db_xref="EnsemblGenomes-Tr:CAB11947" /db_xref="GOA:Q45583" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11571" /db_xref="UniProtKB/Swiss-Prot:Q45583" /translation="MTQDISLSFYKPEHLPELQSFTLTNDDKRFTSLPKEVLSQALGI QDRYPVVILKDDLPVGFFILHASKETLASYSNNPFALLLSSLSLTAVHHGKGYAKKAM LLLPAFVSGYFPWCDEIILAVNHLNIRAKHLYMKSGFLDKGRRRIGPLGEQLILHHFL *" /label="ybbJ CDS" gene complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /label="ybbJ gene" CDS complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388053.2" /db_xref="EnsemblGenomes-Gn:BSU01720" /db_xref="EnsemblGenomes-Tr:CAB11948" /db_xref="InterPro:IPR007553" /db_xref="SubtiList:BG11572" /db_xref="UniProtKB/Swiss-Prot:Q45584" /translation="MILVSSCLGGIECRYNGSHAASEKIRKLVDEKKAVMACPELLGG FSTPREPAEIIGGTGEDVLNGTAKIVTASGEDVTELYMEGAAKTLAYAKEINASAVIL KENSPSCGSGFIYNGTFSGKKITGSGVTAALLKQAGYRVISENELNDIL*" /label="ybbK CDS" gene complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /label="ybbK gene" promotor_-10 complement(193650..193669) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(193671) /Source="Nicolas_upshifts" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(193684..193685) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 193744..193751 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" promotor_-10 193766..193785 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" upshifts 193777 /Source="Nicolas_upshifts" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" tRNA 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu2 tRNA" gene 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /label="trnSL-Glu2 gene" tRNA 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val1 tRNA" gene 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /label="trnSL-Val1 gene" tRNA 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Thr1 tRNA" gene 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /label="trnSL-Thr1 gene" tRNA 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Tyr1 tRNA" gene 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /label="trnSL-Tyr1 gene" tRNA 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gln2 tRNA" gene 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /label="trnSL-Gln2 gene" downshifts 194223 /Source="Nicolas_upshifts" /id="D61" /incds=0 /nref=10 /ntot=91 /MaxReadThrough="4.25215" /MaxDrop="3.84626" /score="25.5087424" /energy="-11.4" /TU="U118" /idTUdmin="U118" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" S_feature 194268..194385 /Source="Nicolas_S_feature" /locus_tag="new_194669_194786" /HighExp="Paraq, BMM, H2O2, Heat, G180, G135, Oxctl, G150, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S67" promotor_-35 194386..194395 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" upshifts 194387 /Source="Nicolas_upshifts" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" promotor_-10 194407..194422 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" CDS 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11866510, 15130127, 16629676, 21542858, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11866510, 15130127, 16629676, 21542858, 28319136, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor W" /protein_id="NP_388054.1" /db_xref="EnsemblGenomes-Gn:BSU01730" /db_xref="EnsemblGenomes-Tr:CAB11949" /db_xref="GOA:Q45585" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014294" /db_xref="InterPro:IPR036388" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11573" /db_xref="UniProtKB/Swiss-Prot:Q45585" /translation="MEMMIKKRIKQVKKGDQDAFADIVDIYKDKIYQLCYRMLGNVHE AEDIAQEAFIRAYVNIDSFDINRKFSTWLYRIATNLTIDRIRKKKPDYYLDAEVAGTE GLTMYSQIVADGVLPEDAVVSLELSNTIQQKILKLPDKYRTVIVLKYIDELSLIEIGE ILNIPVGTVKTRIHRGREALRKQLRDL*" /label="sigW CDS" gene 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /label="sigW gene" CDS 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15130127, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 28319136, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(W) factor" /protein_id="NP_388055.1" /db_xref="EnsemblGenomes-Gn:BSU01740" /db_xref="EnsemblGenomes-Tr:CAB11950" /db_xref="GOA:Q45588" /db_xref="InterPro:IPR027383" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11574" /db_xref="UniProtKB/Swiss-Prot:Q45588" /translation="MSCPEQIVQLMHMHLDGDILPKDEHVLNEHLETCEKCRKHFYEM EKSIALVRSTSHVEAPADFTANVMAKLPKEKKRASVKRWFRTHPVIAAAAVFIILMGG GFFNSWHNDHNFSVSKQPNLVVHNHTVTVPEGETVKGDVTVKNGKLIIKGKIDGDVTV VNGEKYMASAGQVTGQIEEINQLFDWTWYKMKSAGKSVLDAFNPNGEE*" /label="rsiW CDS" gene 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /label="rsiW gene" downshifts complement(195443) /Source="Nicolas_upshifts" /id="D62" /incds=1 /nref=2 /ntot=181 /MaxReadThrough="1.52124" /MaxDrop="3.24828" /score="0.305471631" /energy="-6.9" /TU="NA" /idTUdmin="U120" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(195601..195701) /Source="Nicolas_upshift_promotors" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts 195631 /Source="Nicolas_upshifts" /id="D63" /incds=0 /nref=251 /ntot=269 /MaxReadThrough="4.26924" /MaxDrop="8.34597" /score="7.39786279" /energy="-10.8" /TU="U119" /idTUdmin="U119" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" upshifts complement(195641) /Source="Nicolas_upshifts" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 195700..195707 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-35" promotor_-10 195722..195741 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-10" S_feature 195731..195811 /Source="Nicolas_S_feature" /locus_tag="new_196132_196212" /HighExp="dia5, Diami, H2O2, dia15, G135, Cold, G180, Paraq, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA" /TUlongPSig="1, 1" /label="S68" upshifts 195731 /Source="Nicolas_upshifts" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="upshifts" CDS 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /EC_number="2.7.7.85" /function="16.13: Shape" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase" /protein_id="NP_388056.2" /db_xref="EnsemblGenomes-Gn:BSU01750" /db_xref="EnsemblGenomes-Tr:CAB11951" /db_xref="GOA:Q45589" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR034701" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG11577" /db_xref="UniProtKB/Swiss-Prot:Q45589" /translation="MAFEDIPFLQYLGNAVDILLVWYVIYKLIMVIRGTKAVQLLKGI VVIVLVRMASQYLGLSTLQWLMDQAITWGFLAIIIIFQPELRRALEQLGRGRFFSRSG TPVEEAQQKTIEAITKAINYMAKRRIGALLTIERDTGMGDYIETGIPLNAKVSSELLI NIFIPNTPLHDGAVIMKNNEIAAAACYLPLSESPFISKELGTRHRAAVGISEVTDSLT IIVSEETGGVSVAKNGDLHRELTEEALKEMLEAEFKKNTRDTSSNRWYWRGKKNG*" /label="cdaA CDS" gene 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /label="cdaA gene" CDS 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /experiment="publication(s) with functional evidences, PMID:16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of diadenylate cyclase activity" /protein_id="NP_388057.2" /db_xref="EnsemblGenomes-Gn:BSU01760" /db_xref="EnsemblGenomes-Tr:CAB11952" /db_xref="GOA:O34659" /db_xref="InterPro:IPR012505" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12703" /db_xref="UniProtKB/Swiss-Prot:O34659" /translation="MDKFLNNRWAVKIIALLFALLLYVAVNSNQAPTPKKPGESFFPT STTDEATLTDIPVKAYYDDENYVVTGVPQTVNVTIKGSTSAVKKARQTKNFEIYADME HLKTGTHKVELKAKNVSDGLTISINPSVTTVTIQERTTKSFPVEVEYYNKSKMKKGYS PEQPIVSPKNVQITGSKNVIDNISLVKASVNLENADETIEKEAKVTVYDKDGNALPVD VEPSVIKITVPVTSPSKKVPFKIERTGSLPDGVSIANIESSPSEVTVYGSQDVLDSLE FIDGVSLDLSKINKDSDIEADIPLPDGVKKISPSKVTLHIEVDSEADQKFENVPIKTV GLSSSQNIEFLDPESQAIDVTAKGSPTNINKLKKSDIELYVNVSDLEDGEHSVKLEVN GPQNVTWSLGRKNAKIKLTSKKSNTSTNDNSSNTSGNQDTDKQTNDQKNNQQEDTKNT DKNNNDQNQDGNKDQNQDQDEDESTANSQSSSE*" /label="cdaR CDS" gene 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /label="cdaR gene" CDS 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /EC_number="5.4.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10671448, 10913078, 12089032, 21154411, 26240071, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671448, 10913078, 12089032, 21154411, 26240071, 27074767; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoglucosamine mutase" /protein_id="NP_388058.1" /db_xref="EnsemblGenomes-Gn:BSU01770" /db_xref="EnsemblGenomes-Tr:CAB11953" /db_xref="GOA:O34824" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR006352" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG12704" /db_xref="UniProtKB/Swiss-Prot:O34824" /translation="MGKYFGTDGVRGVANSELTPELAFKVGRFGGYVLTKDKQRPKVL IGRDTRISGHMLEGALVAGLLSIGAEVMRLGVISTPGVSYLTKAMDAEAGVMISASHN PVQDNGIKFFGGDGFKLSDEQEAEIERLMDEPEDKLPRPVGADLGLVNDYFEGGQKYL QFLKQTADEDFTGIHVALDCANGATSSLATHLFADLDADVSTMGTSPNGLNINDGVGS THPEALSAFVKEKNADLGLAFDGDGDRLIAVDEKGNIVDGDQIMYICSKHLKSEGRLK DDTVVSTVMSNLGFYKALEKEGIKSVQTAVGDRYVVEAMKKDGYNVGGEQSGHLIFLD YNTTGDGLLSAIMLMNTLKATGKPLSELAAEMQKFPQLLVNVRVTDKYKVEENEKVKA VISEVEKEMNGDGRILVRPSGTEPLVRVMAEAKTKELCDEYVNRIVEVVRSEMGLE*" /label="glmM CDS" gene 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /label="glmM gene" downshifts 199437 /Source="Nicolas_upshifts" /id="D64" /incds=0 /nref=126 /ntot=216 /MaxReadThrough="5.32721" /MaxDrop="5.02497" /score="13.5044076" /energy="-17.5" /TU="U121" /idTUdmin="U121" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 199461..199469 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 199477 /Source="Nicolas_upshifts" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 199483..199502 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 199529..199534 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 199550..199569 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 199556 /Source="Nicolas_upshifts" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_feature 199600..199616 /Source="Nicolas_upshift_promotors" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 199613 /Source="Nicolas_upshifts" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /product="riboswitch and ribozyme (GlmS-glucosamine-6-P)" /experiment="publication(s) with functional evidences, PMID:16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261; Product type n: RNA" /label="glmSA RNA" gene 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /label="glmSA gene" S_feature 199787..199875 /Source="Nicolas_S_feature" /locus_tag="new_200188_200276" /HighExp="M40t90, M0t90, M9-stat, Lbstat, T2.30H, T2.0H, T3.0H, T1.30H, T1.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.498, 0.999, 0.754" /TUlongSig="SigA, SigWXY, SigA" /TUlongPSig="1, 1, 1" /label="S69" CDS 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /EC_number="2.6.1.16" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15029187, 17114942, 17283212, 17322533, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine-D-fructose-6-phosphate amidotransferase" /protein_id="NP_388059.1" /db_xref="EnsemblGenomes-Gn:BSU01780" /db_xref="EnsemblGenomes-Tr:CAB11954" /db_xref="GOA:P0CI73" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005855" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR035466" /db_xref="InterPro:IPR035490" /db_xref="SubtiList:BG10948" /db_xref="UniProtKB/Swiss-Prot:P0CI73" /translation="MCGIVGYIGQLDAKEILLKGLEKLEYRGYDSAGIAVANEQGIHV FKEKGRIADLREVVDANVEAKAGIGHTRWATHGEPSYLNAHPHQSALGRFTLVHNGVI ENYVQLKQEYLQDVELKSDTDTEVVVQVIEQFVNGGLETEEAFRKTLTLLKGSYAIAL FDNDNRETIFVAKNKSPLLVGLGDTFNVVASDAMAMLQVTNEYVELMDKEMVIVTDDQ VVIKNLDGDVITRASYIAELDASDIEKGTYPHYMLKETDEQPVVMRKIIQTYQDENGK LSVPGDIAAAVAEADRIYIIGCGTSYHAGLVGKQYIEMWANVPVEVHVASEFSYNMPL LSKKPLFIFLSQSGETADSRAVLVQVKALGHKALTITNVPGSTLSREADYTLLLHAGP EIAVASTKAYTAQIAVLAVLASVAADKNGINIGFDLVKELGIAANAMEALCDQKDEME MIAREYLTVSRNAFFIGRGLDYFVCVEGALKLKEISYIQAEGFAGGELKHGTIALIEQ GTPVFALATQEHVNLSIRGNVKEVAARGANTCIISLKGLDDADDRFVLPEVNPALAPL VSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE*" /label="glmS CDS" gene 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /label="glmS gene" S_feature complement(201401..>201681) /Source="Nicolas_S_feature" /locus_tag="new_201802_202546_c" /HighExp="S8, S7, S6, S5, S4, BC, S3, Sw, C30, LoTm" /AntisenseName="glmS" /AntisenseCor="4.5056549205256403E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S70" downshifts 201664 /Source="Nicolas_upshifts" /id="D65" /incds=0 /nref=260 /ntot=277 /MaxReadThrough="3.18134" /MaxDrop="7.61794" /score="13.5044076" /energy="-17.5" /TU="NA" /idTUdmin="U122" /TUdmin=2 /isTUend="TRUE" /label="downshifts" SCAR join(201681,201727) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta4" N_region 201682..201726 /note="insertion of 45 bases of unknown origin" /modified_by="User" /label="Delta4" S_feature <201727..201845 /Source="Nicolas_S_feature" /locus_tag="new_220105_220278" /HighExp="LoTm, T5.0H, T4.0H, T3.30H, Pyr, T-2.40H, T3.0H, T-5.40H, S2, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S79" CDS 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase/transferase" /protein_id="NP_388081.2" /db_xref="EnsemblGenomes-Gn:BSU01990" /db_xref="EnsemblGenomes-Tr:CAB11993" /db_xref="GOA:O31431" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12722" /db_xref="UniProtKB/Swiss-Prot:O31431" /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGK GTVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAG YGYSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKA IIAMDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDE EKEIYKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKY AIQNRKDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR*" /label="ybdG CDS" gene 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /label="ybdG gene" CDS 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component system response regulator [YbdK]" /protein_id="NP_388082.1" /db_xref="EnsemblGenomes-Gn:BSU02000" /db_xref="EnsemblGenomes-Tr:CAB11994" /db_xref="GOA:O31432" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12723" /db_xref="UniProtKB/Swiss-Prot:O31432" /translation="MKGYRILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQ KVDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKP FDPRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYL YENRDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLN TVVKK*" /label="ybdJ CDS" gene 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /label="ybdJ gene" promotor_-35 203390..203396 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 203410..203429 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 203428 /Source="Nicolas_upshifts" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component system sensor histidine kinase [YbdJ]" /protein_id="NP_388083.1" /db_xref="EnsemblGenomes-Gn:BSU02010" /db_xref="EnsemblGenomes-Tr:CAB11995" /db_xref="GOA:O31433" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12724" /db_xref="UniProtKB/Swiss-Prot:O31433" /translation="MLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMPFHRSFAY PAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVKRADEIG ELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLEDQCHG QAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDYLYSM SGIELHYKPADQDVIWMSNTLWMERLFDNIFQNTLRHSKAKKMEVTIEHGDVFIRDDG IGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTGFLFSKE*" /label="ybdK CDS" gene 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /label="ybdK gene" promotor_-35 204491..204493 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 204509..204528 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 204512 /Source="Nicolas_upshifts" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097672.1" /db_xref="EnsemblGenomes-Gn:BSU02019" /db_xref="EnsemblGenomes-Tr:CAX52542" /db_xref="UniProtKB/Swiss-Prot:C0H3T1" /translation="MNIICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAAV RAKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD*" /label="ybzI CDS" gene 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /label="ybzI gene" downshifts 204742 /Source="Nicolas_upshifts" /id="D73" /incds=0 /nref=120 /ntot=235 /MaxReadThrough="2.82444" /MaxDrop="4.652" /score="22.3698707" /energy="-12.1" /TU="U135" /idTUdmin="U136" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /EC_number="2.7.11.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21304896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein kinase" /protein_id="NP_388085.1" /db_xref="EnsemblGenomes-Gn:BSU02030" /db_xref="EnsemblGenomes-Tr:CAB11997" /db_xref="GOA:O31435" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG12726" /db_xref="UniProtKB/Swiss-Prot:O31435" /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTD ILAQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKNIHHPQIPGFIDEFIIDGQAYYVM QFIEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDG RLCLIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEEL TLTKEVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT*" /label="ybdM CDS" gene complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /label="ybdM gene" CDS complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16794953; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388086.1" /db_xref="EnsemblGenomes-Gn:BSU02040" /db_xref="EnsemblGenomes-Tr:CAB11998" /db_xref="SubtiList:BG12727" /db_xref="UniProtKB/Swiss-Prot:O31436" /translation="MVKKWLIQFAVMLSVLSTFTYSASAVGVTAITGNNSFDTAMPIG YWKYKNIDTTILEAGQDEAYFTFTANKGEKVYMRSTYQSAYTGMKIEIYDKNRIPVSQ GTEVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQ FSGVAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHL IMTSENNEWSRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKID YEYDVTKQF*" /label="ybdN CDS" gene complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /label="ybdN gene" downshifts complement(205664) /Source="Nicolas_upshifts" /id="D74" /incds=0 /nref=95 /ntot=184 /MaxReadThrough="1.56932" /MaxDrop="4.95806" /score="36.4950689" /energy="-11.9" /TU="NA" /idTUdmin="U137" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(205713..205732) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(205746..205755) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(205748) /Source="Nicolas_upshifts" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(206512..206531) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(206537) /Source="Nicolas_upshifts" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(206546..206553) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 206567..206574 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-35" promotor_-10 206588..206606 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-10" upshifts 206590 /Source="Nicolas_upshifts" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="upshifts" CDS 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388087.1" /db_xref="EnsemblGenomes-Gn:BSU02050" /db_xref="EnsemblGenomes-Tr:CAB11999" /db_xref="InterPro:IPR032617" /db_xref="SubtiList:BG12728" /db_xref="UniProtKB/Swiss-Prot:O31437" /translation="MRLNRQFIRTQLIAQNILSKNAPAKRENATENPAAVLEKAYSRL KSQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESD IRIKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEW LFKGKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTE LTFTITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEA YKKYQAAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMDVYKEELEKDPVQKQTASYAI SYYRSELSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGV NY*" /label="ybdO CDS" gene 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /label="ybdO gene" downshifts 207801 /Source="Nicolas_upshifts" /id="D75" /incds=0 /nref=107 /ntot=207 /MaxReadThrough="2.98334" /MaxDrop="4.9582" /score="-3.87053033" /energy="-8.3" /TU="U139" /idTUdmin="U139" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" promotor_-35 207969..207975 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 207989..208008 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 208003..208132 /Source="Nicolas_S_feature" /locus_tag="new_226436_226565" /HighExp="Glu, LoTm, M9-stat, G135, GM-0.2, T-0.40H, Fru, UNK1, MG 120, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD" /TUlongPSig=1 /label="S80" upshifts 208003 /Source="Nicolas_upshifts" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="upshifts" CDS 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388088.1" /db_xref="EnsemblGenomes-Gn:BSU02060" /db_xref="EnsemblGenomes-Tr:CAB12000" /db_xref="GOA:P54425" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11505" /db_xref="UniProtKB/Swiss-Prot:P54425" /translation="MANKELKRGLGARHIQMIALGGTIGVGLFMGSASTISWTGPSVL LAYAICGIFIFFIMRAMGEMLYVEPSTGSFATFGHQYIHPMAGYITAWSNWFQWIIVG MSEIIAVGSYTKYWFPDLPAWIPGIVAMVILGAANLISVKSFGEFEFWFAMIKIVTII LMIIAGIGIIFFGFGNGGDAIGLSNLWSHGGFFAGGFSGFFFALSLVIAAYQGVELIG ITAGEAKDPQNTLRNAIQSIIWRILIFYIGAIFVIVTVYPWDELNSLGSPFVSTFSKI GITAAAGIINFVVITAAMSGCNSGIFSAGRMLYTLGVNGQAPKFFKKISRNGVPLYGT IAVLIGLAVGVVLNYIAPPKIFVYVYSASVLPGMIPWFIILISHIGFRKAKGAALDKH PFKMPFAPFTNYLTIAFLLMVLVGMWFNDDTRISLIVGVIFLALVVISYYVFGIGKRT QANLTKSEQAAE*" /label="ybxG CDS" gene 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /label="ybxG gene" downshifts 209529 /Source="Nicolas_upshifts" /id="D76" /incds=0 /nref=121 /ntot=219 /MaxReadThrough="2.32902" /MaxDrop="5.72049" /score="28.6554212" /energy="-8.5" /TU="NA" /idTUdmin="U140" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" promotor_-35 209567..209573 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 209587..209598 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 209588 /Source="Nicolas_upshifts" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="upshifts" CDS 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9016963" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9016963; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific SASP protein" /protein_id="NP_388089.1" /db_xref="EnsemblGenomes-Gn:BSU02070" /db_xref="EnsemblGenomes-Tr:CAB12001" /db_xref="GOA:P54379" /db_xref="InterPro:IPR020255" /db_xref="SubtiList:BG11504" /db_xref="UniProtKB/Swiss-Prot:P54379" /translation="MDVTLGYLRESLSNHLENEVCQRICKKMLAKRYANEEEFVKDLD DNEMSFLNHVLEKEIKYAQNEQDQKRAKELNEVYELLL*" /label="csgA CDS" gene 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /label="csgA gene" CDS 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388090.1" /db_xref="EnsemblGenomes-Gn:BSU02080" /db_xref="EnsemblGenomes-Tr:CAB12002" /db_xref="InterPro:IPR035314" /db_xref="SubtiList:BG11506" /db_xref="UniProtKB/Swiss-Prot:P54426" /translation="MGAIERSGYTFQPEFSVVRQNGAIHVYHQGEFVEEIEFEFNGEY PDHDLIEELVNHYCFEHEI*" /label="ybxH CDS" gene 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /label="ybxH gene" downshifts 210071 /Source="Nicolas_upshifts" /id="D77" /incds=0 /nref=17 /ntot=40 /MaxReadThrough="0.194030000000001" /MaxDrop="4.779" /score="29.4617878" /energy="-15.6" /TU="NA" /idTUdmin="U141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /EC_number="3.5.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14742199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14742199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported beta-lactamase" /protein_id="NP_388091.1" /db_xref="EnsemblGenomes-Gn:BSU02090" /db_xref="EnsemblGenomes-Tr:CAB12003" /db_xref="GOA:P54427" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR002137" /db_xref="InterPro:IPR012338" /db_xref="PDB:5E2F" /db_xref="SubtiList:BG11507" /db_xref="UniProtKB/Swiss-Prot:P54427" /translation="MKKWIYVVLVLSIAGIGGFSVHAASSAHEKHLNVSKMNVDDEFK DTDGTFILHDLQKDQTFVYNRKRANQRQTPQSTFKVVNALIGLQVKAVRDEYDVKRWD GVKREFESWNRDHTLGSAMRESAIWYYQALARDIGEERMKTWLHTLSYGNEDISGGID QFWLQSSLTISPLEQETFLEKLAKEELPFDKPVMKIVKRMMIQEEGDHYTLYGKTGTR LTDMGLGWFVGFIKTEHGSYVFVTNVDDSGTKAKNITVDILKKYGLITS*" /label="ybxI CDS" gene complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /label="ybxI gene" promotor_-10 complement(210941..210959) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(210949) /Source="Nicolas_upshifts" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(210970..210978) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 211033..211039 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 211054..211072 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 211060 /Source="Nicolas_upshifts" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="upshifts" CDS 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /EC_number="1.11.2.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10529095, 12519760, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10529095, 12519760, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid beta-hydroxylating cytochrome P450" /protein_id="NP_388092.1" /db_xref="EnsemblGenomes-Gn:BSU02100" /db_xref="EnsemblGenomes-Tr:CAB12004" /db_xref="GOA:O31440" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002401" /db_xref="InterPro:IPR036396" /db_xref="PDB:1IZO" /db_xref="PDB:2ZQJ" /db_xref="PDB:2ZQX" /db_xref="SubtiList:BG12729" /db_xref="UniProtKB/Swiss-Prot:O31440" /translation="MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGK NFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSL MTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVK ERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMA FHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSRER EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEF RPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQS LHYSLARMPSLPESGFVMSGIRRKS*" /label="cypC CDS" gene 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /label="cypC gene" misc_feature 211404..211411 /Source="Nicolas_upshift_promotors" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 211414 /Source="Nicolas_upshifts" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 212338 /Source="Nicolas_upshifts" /id="D78" /incds=0 /nref=5 /ntot=36 /MaxReadThrough="2.65245" /MaxDrop="6.12325" /score="-7.42298703" /energy="-14.7" /TU="NA" /idTUdmin="U143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388093.1" /db_xref="EnsemblGenomes-Gn:BSU02110" /db_xref="EnsemblGenomes-Tr:CAB12005" /db_xref="SubtiList:BG12754" /db_xref="UniProtKB/Swiss-Prot:O31441" /translation="MKQKLLLSGLAVSTVGITSYLLKDPSNRQKAREFIHSMKMKITK QPDMETFPVDKAGHPDPQDIEDNKMVSEGSMYPVQYYDEKKK*" /label="ybyB CDS" gene complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /label="ybyB gene" downshifts complement(212405) /Source="Nicolas_upshifts" /id="D79" /incds=0 /nref=155 /ntot=247 /MaxReadThrough="3.63752" /MaxDrop="7.83539" /score="8.86703843" /energy="-12.4" /TU="U145" /idTUdmin="U145" /TUdmin="-387" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(212676..212694) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(212685) /Source="Nicolas_upshifts" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(212708..212714) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 212838..212845 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 212855 /Source="Nicolas_upshifts" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 212861..212880 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/amino acid transporter" /protein_id="NP_388094.2" /db_xref="EnsemblGenomes-Gn:BSU02120" /db_xref="EnsemblGenomes-Tr:CAB12006" /db_xref="GOA:Q45577" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12730" /db_xref="UniProtKB/Swiss-Prot:Q45577" /translation="MNQLHRRMGTFSLMMVGLGSMIGSGWLFGAWRAAQIAGPAAIIS WVIGMVVILFIALSYSELGSMFPEAGGMVKYTQYSHGSFIGFIAGWANWIAIVSVIPV EAVASVQYMSSWPWEWAKWTSGLVKNGTLTGEGLAFASVLLLIYFLLNYWTVNLFSKA NSLITIFKIIIPGLTIGALLFVGFHGENFTGGQSIAPNGWASVLTAVATSGIVFAFNG FQSPINMAGEAKNPGKSIPIAVVGSLFVATVIYVLLQIAFIGAVNPSDIAHGWSHLNF NSPFADLAIALNINWLVIVLYADAFVSPSGTGITYTATTSRMIYGMEKNKYMPSIFGK LHPIYGVPRQAMFFNLIVSFIFLFLFRGWGVLAEIISVATLISYITGPITVMTLRRTG KDLYRPLRLKGLNVIAPLGFIFASLVLYWARWPLTGQVLFIILIGLPIYFYYQAKAKW KGFGRNFKAGVWMVFYLLAMMVISYLGSDKFGGLNVIHYGWDMVLIAMVSLVFYVWAL KSGYQTEYLKDAKEINSQLLNGQSEAAAGKE*" /label="ybeC CDS" gene 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /label="ybeC gene" downshifts 214517 /Source="Nicolas_upshifts" /id="D80" /incds=0 /nref=183 /ntot=273 /MaxReadThrough="0.8051" /MaxDrop="6.79949" /score="24.7668372" /energy="-12.2" /TU="NA" /idTUdmin="U146" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10913081, 21966272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 21966272; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted glycerophosphoryl diester phosphodiesterase" /protein_id="NP_388095.1" /db_xref="EnsemblGenomes-Gn:BSU02130" /db_xref="EnsemblGenomes-Tr:CAB12007" /db_xref="GOA:P37965" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="PDB:5T91" /db_xref="PDB:5T9B" /db_xref="PDB:5T9C" /db_xref="SubtiList:BG10646" /db_xref="UniProtKB/Swiss-Prot:P37965" /translation="MRKNRILALFVLSLGLLSFMVTPVSAASKGNLLSPDRILTVAHR GASGYVPEHTILSYETAQKMKADFIELDLQMTKDGKLIVMHDEKLDRTTNGMGWVKDH TLADIKKLDAGSWFNEAYPEKAKPQYVGLKVPTLEEVLDRFGKHANYYIETKSPDTYP GMEEKLIASLQKHKLLGKHSKPGQVIIQSFSKESLVKVHQLQPNLPTVQLLEAKQMAS MTDAALEEIKTYAVGAGPDYKALNQENVRMIRSHGLLLHPYTVNNEADMHRLLDWGVT GVFTNYPDLFHKVKKGY*" /label="glpQA CDS" gene complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /label="glpQA gene" downshifts complement(214592) /Source="Nicolas_upshifts" /id="D81" /incds=0 /nref=61 /ntot=107 /MaxReadThrough="2.31368" /MaxDrop="7.76277" /score="9.56390732" /energy="-11.4" /TU="NA" /idTUdmin="U147" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(215505) /Source="Nicolas_upshifts" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(215514..215530) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(215539..215545) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8012593, 11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012593, 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate permease" /protein_id="NP_388096.1" /db_xref="EnsemblGenomes-Gn:BSU02140" /db_xref="EnsemblGenomes-Tr:CAB12008" /db_xref="GOA:P37948" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR005267" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR021159" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10645" /db_xref="UniProtKB/Swiss-Prot:P37948" /translation="MLNIFKPAPHIERLDDSKMDAAYKRLRLQVFIGIFIGYAGYYLL RKNFAFAIPYLQEQGFSKTELGLVLAAVSIAYGFSKFIMGMVSDRCNPRYFLATGLFL SAIVNILFVSMPWVTSSVTIMFIFMFINGWFQGMGWPPCGRTMAHWFSISERGTKMSI WNVAHNIGGGILAPLVTLGIAMFVTWKSVFFFPAIIAIIISFLIVLLVRDTPQSCGLP PIEEYRNDYPKHAFKNQEKELTTKEILFQYVLNNKFLWYIAFANVFVYFVRYGVVDWA PTYLTEAKGFSPEDSRWSYFLYEYAGIPGTILCGWISDRFFKSRRAPAGVLFMAGVFI AVLVYWLNPAGNPLVDNIALISIGFLIYGPVMLIGLQAIDLAPKKAAGTAAGLTGFFG YIGGSAFANAIMGFVVDRFNWNGGFIMLISSCILAIVFLALTWNTGKRAEHV*" /label="glpT CDS" gene complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /label="glpT gene" promotor_-35 216543..216552 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 216565..217191 /Source="Nicolas_S_feature" /locus_tag="new_234998_235624" /HighExp="S6, S8, S7, S5, BT, B36, G/S, C30, Pyr, B60" /AntisenseName="glpT" /AntisenseCor="-5.0958691169636701E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S81" promotor_-10 216565..216584 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 216565 /Source="Nicolas_upshifts" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216896..216968) /Source="Nicolas_S_feature" /locus_tag="new_235329_235401_c" /HighExp="G150, Oxctl, Paraq, S0, Diami, H2O2, Lbexp, dia5, dia0, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.042, 0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S82" promotor_no_box complement(216928..217028) /Source="Nicolas_upshift_promotors" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(216968) /Source="Nicolas_upshifts" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216970..217056) /Source="Nicolas_S_feature" /locus_tag="new_235403_235489_c" /HighExp="G150, Oxctl, S0, Diami, Lbexp, dia5, Paraq, dia0, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S83" promotor_-10 complement(217046..217065) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(217060) /Source="Nicolas_upshifts" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(217078..217085) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388097.1" /db_xref="EnsemblGenomes-Gn:BSU02150" /db_xref="EnsemblGenomes-Tr:CAB12009" /db_xref="GOA:O31442" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG12731" /db_xref="UniProtKB/Swiss-Prot:O31442" /translation="MDELDIAFFILPLGIMLLSIVGTCICKNPYLMPMLSLVISLVLT FTIFNQSFLGWAVVYSLVSLALSYITLIVVRKRKESGN*" /label="ybeF CDS" gene 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /label="ybeF gene" promotor_-35 217464..217471 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 217471 /Source="Nicolas_upshifts" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 217487..217506 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator with acetyltransferase domain" /protein_id="NP_388098.1" /db_xref="EnsemblGenomes-Gn:BSU02160" /db_xref="EnsemblGenomes-Tr:CAB12010" /db_xref="GOA:O31443" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12732" /db_xref="UniProtKB/Swiss-Prot:O31443" /translation="MKTRESSVGLKFRKFNRFYTNVLGFLNEHIYDSPFSLTETRILF EIYNTPNCTAKALQDKLGLDRGYVSRIVKQFEKEDLIYKQRSKDDARHHYIFVTETGK TIYKKLEEKANEQVELMLKVINQKEQHKLAEAMAEIEAILSQSLSARASEISIRDYFL SEDLQLLIEKQRQFYAEAHGWDDTFLAYLQETFDADIEKIWIAESGGKFAGSVGLVKH DEKTVQLRWFLVDADFRGRGLGTQLLEHLVAYCQDMKFDRIFLWTVSTMAEARPLYKK FGFRISEVKQEAPLWGQQLTEERWDLELS*" /label="ybfA CDS" gene 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /label="ybfA gene" CDS 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carboxylate transporter" /protein_id="NP_388099.1" /db_xref="EnsemblGenomes-Gn:BSU02170" /db_xref="EnsemblGenomes-Tr:CAB12011" /db_xref="GOA:O31444" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12733" /db_xref="UniProtKB/Swiss-Prot:O31444" /translation="MKRLHYAWIIVSVTFLILLAVQGVRLSFGAFVEPWERQFSIDRS TISLISTVSFIVYGISQPVIGRLVDKWGARAVLAWSALLTGVSIFLTYLVTSPWQLFL LYGLGVSLGVGGASNVAASVLVVNWFSKKRGLAFGIMEAGFGAGQMLLVPGSLMLIHW FSWKLTVVVLGLLLIVIVFPAALLMLRNNPSEKNTEPIGGLAASEKETAPKTTALSVA GMFRMRQFWFLIFPFLICGFTTVGLMDTHLIPFSHDHGFSTTVTSAAVSLLAGFNIAG ILLSGIVADRWSSRKILCILYAVRALSIVILIYSHEPYLLLAFAILFGLVDFATVAPT QMLATQYFQNYSIGLMIGWLSLAHQIGSALGAYVPGVIYTVTGEYTLAFYLSIGMLVL ASVMNVMLREPAAVTRDSAAVVDK*" /label="ybfB CDS" gene 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /label="ybfB gene" downshifts 219686 /Source="Nicolas_upshifts" /id="D82" /incds=0 /nref=57 /ntot=187 /MaxReadThrough="1.17226" /MaxDrop="5.55429" /score="12.1347284" /energy="-9.5" /TU="NA" /idTUdmin="U151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminal end)" /db_xref="EnsemblGenomes-Gn:BSU02180" /db_xref="EnsemblGenomes-Tr:CAB12012" /db_xref="GOA:O31445" /db_xref="PSEUDO:CAB12012.2" /db_xref="SubtiList:BG12734" /db_xref="UniProtKB/Swiss-Prot:O31445" /translation="MNHCLHSNTLAKIVCTVTLITLYFYFFSTRFNELIELAVQMFFA LIGLFWVFIVSPFSRKVQISERFKQKSENARIVGMIDFVLEQKYKKSISE*" /label="ybfEc CDS" gene complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /pseudo /label="ybfEc gene" downshifts complement(219784) /Source="Nicolas_upshifts" /id="D83" /incds=0 /nref=4 /ntot=189 /MaxReadThrough="2.49989" /MaxDrop="3.7302" /score="13.7144473" /energy="-12.6" /TU="U153" /idTUdmin="U153" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function YbfE (N-terminal fragment)" /db_xref="PSEUDO:SOX90538.1" /translation="MLNQLKVFFSEPLLTFKHTCQNRMYCDINNVILLFFQHSF*" /label="ybfEn CDS" gene complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /pseudo /label="ybfEn gene" S_feature complement(220016..220136) /Source="Nicolas_S_feature" /locus_tag="new_238449_238569_c" /HighExp="Lbexp, dia0, LBGexp, G150, Mt0, H2O2, dia5, M0t45, G135, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-" /TUshortPSig="0.899, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S84" promotor_-10 complement(220121..220139) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(220136) /Source="Nicolas_upshifts" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(220138..220210) /Source="Nicolas_S_feature" /locus_tag="new_238571_238643_c" /HighExp="Lbexp, dia0, LBGexp, HPh, G150, H2O2, dia5, Mt0, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S85" promotor_-35 complement(220156..220161) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388101.1" /db_xref="EnsemblGenomes-Gn:BSU02190" /db_xref="EnsemblGenomes-Tr:CAB12013" /db_xref="GOA:O31446" /db_xref="SubtiList:BG12735" /db_xref="UniProtKB/Swiss-Prot:O31446" /translation="MKNDQIVFEKTKNIAHDINQMQNQQEIIDYLFRQDSLTLNQLKH YYSEPSLPLQFLVKVAVLCMFISMTLASFLFIQAKEVFTNTILSDISPAVFSIFTVIC IFMTYTKIIKKGNKNKGKASLNQRSEFYEKNKLINTILYKKYKMDQQNIQANKHTASD NEDSMNFSAVLNHVLTISKNDKELLGYLDTRDNAMLSQLKAYFSTRPFSLPHYMSLMF CGSIIVVYATSLFSGQINYIDIPHIFIFLLLIIFLKILIDLIKLLNISRKGQLHTVLH FAQRAEYLRMRGVIDFILTERYNKKIM*" /label="ybfF CDS" gene complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /label="ybfF gene" S_feature complement(221123..221210) /Source="Nicolas_S_feature" /locus_tag="new_239556_239643_c" /HighExp="LBGexp, Lbexp, G150, dia5, dia0, G135, Oxctl, H2O2, Mt0, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S86" CDS complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pepdidoglycan binding protein" /protein_id="NP_388102.1" /db_xref="EnsemblGenomes-Gn:BSU02200" /db_xref="EnsemblGenomes-Tr:CAB12014" /db_xref="GOA:O31447" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG12736" /db_xref="UniProtKB/Swiss-Prot:O31447" /translation="MVDEMVLITQQWLNDTYSGKHGYNPVEESGKTGWDTIYGLTRAL QIELGISEPADNFGPTTQRLFKPLKRQAPDSKPSNMNFILQGALWCKGFNPGGFTGVF YEKTENAVKEFQKAAGLTTQDGIVTTLIMKALLDMSAFKLVSGGDSRIRQIQQNLNRD YNDYIGLMPCDGLYGRDTNKALIYALQKEEGMSTSVANGFFGNGTTSLCPTLTPGDSR TGFVLIVQYALYCNGKSFDPGEFDGKYGVGVVSAVKAFQEFMCLPQTGYADMPTIKAL LSSSGDTTRTASACDTATIITAEKAQTLRNNGYKTVGRYLTGNVRTSSGLTSKALTSK ELAVILDAGLKVFPIYQDGGYESSYFVKDQGTRDAYSAASAARRLGFPSGTTIYFAVD FDAYDYEVTDKIIPYFQEIKSAFTKMQTFSTAPKYEIGVYGPRNICIRTSEAGLTKYS FVANMSTGFSGNLGYPMPNNWAFDQFYEGTIGSGSGSIGIDKDGYSGRDSGASNVNPP SDPVYDARLRTLTDILSTIPALENLTSLANAMFEFDTTETIFTSPELDIILSTSLLAT IPSEGSPNTITITNGKPGAYITGLLGDTQTSLTASQIDSYQNLLNSLSLSVRNGYLEV YVNPTAESLNIQIKIYTPDIPVGDNVTTGLTTTITFKIKTYKGVPVTSPESELALDWP SYDQYLFPVVGVAALLLIGNMGSDLTNNKGVKVATALSAMLLAIFAYYTS*" /label="ybfG CDS" gene complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /label="ybfG gene" misc_feature complement(223444..223462) /Source="Nicolas_upshift_promotors" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(223456) /Source="Nicolas_upshifts" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388103.1" /db_xref="EnsemblGenomes-Gn:BSU02210" /db_xref="EnsemblGenomes-Tr:CAB12015" /db_xref="GOA:O31448" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12737" /db_xref="UniProtKB/Swiss-Prot:O31448" /translation="MNIQRETSGHIAAIVTILIWGTTFISTKVLLADFSPMEILFYRF LMGFIALILVRPNMIPFRNWRQELLFAGAGLFGVTLYFLLENIALTYTYASNVGMIVS IIPMITAVLAHFLLEGEKLRLTFLIGFISALIGLLLITFNGNVVLRLNPLGDIMAAGA ALVFGGYSIFMKKLSAYEYHIIELTQRVFLYGLLFMVPALFLFDFHFDLSRFSSASNI LNMLFLGIGASALCFATWNYSVGVLGAVKSSAYIYMVPVITIAASVLILHENMTWIAL LGGALTLLGLYISELKPKAKLLENGCKMDA*" /label="ybfH CDS" gene complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /label="ybfH gene" CDS complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family, cupin family)" /protein_id="NP_388104.1" /db_xref="EnsemblGenomes-Gn:BSU02220" /db_xref="EnsemblGenomes-Tr:CAB12016" /db_xref="GOA:O31449" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12738" /db_xref="UniProtKB/Swiss-Prot:O31449" /translation="MQNETRTLQLDPHLHIEAYRFKGIMQKFPNHFHDYYVIGFIEKG QRYLACQDQEYIINPGDLLLFNPRDTHSCEQIDGRTLDYRCINVMPDIMEKAVKEITG SGHLPYFSQHVLFRHELTASLQELHILISEEKQALRKEELFLHLLEELIRHYSDVTFL SSVPEPSDEVKMVCEFLEEHYAENVTLNDLSELTGWSKYHLLRSFTKQKGITPNSYME TIRINQAKKLLEQGVRPIDAAFQTGFSDQSHMTKFFKRQVGLTPKQYMKIFEKELHR* " /label="ybfI CDS" gene complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /label="ybfI gene" misc_feature complement(225255..225274) /Source="Nicolas_upshift_promotors" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(225262) /Source="Nicolas_upshifts" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 225402..225405 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 225420..225439 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 225425 /Source="Nicolas_upshifts" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="upshifts" CDS 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /EC_number="2.1.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496533; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase 2" /protein_id="NP_388105.1" /db_xref="EnsemblGenomes-Gn:BSU02230" /db_xref="EnsemblGenomes-Tr:CAB12017" /db_xref="GOA:P39771" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005862" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10924" /db_xref="UniProtKB/Swiss-Prot:P39771" /translation="MYQSKKVLLLGSGELGKEVVIEAQRLGVQTVAVDSYEHAPAMQV AHNSYVVDMLDPEQIRTIIEKENPDLIVPEVEAIATDELLKLEEEGFHVIPNARAAKL TMDREGIRRLAAETLGLATAGYEFANTYDEFIQAAAQIGFPCVVKPLMSSSGKGQSVC RSEADLESCWETAMEGGRVKNGRVIVEEFIPFESEITLLTVRAVNGTAFCEPIGHVQK DGDYIESWQPHDMTEQQIEEAKHIAKTITDELGGYGLFGVELFLAKDRVYFSEVSPRP HDTGLVTLVTQNLSEFALHVRAILGFPITEITQLSPGASRPLKAPEELADYTVEGLEN ALAVPKTQVRVFGKPITKAGRRMAVALSAADSVETARENAKKALDQLILK*" /label="purT CDS" gene 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /label="purT gene" downshifts 226594 /Source="Nicolas_upshifts" /id="D84" /incds=0 /nref=100 /ntot=189 /MaxReadThrough="2.6996" /MaxDrop="5.22319" /score="39.2561117" /energy="-15.1" /TU="NA" /idTUdmin="U155" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 226674..226679 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-35" upshifts 226688 /Source="Nicolas_upshifts" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="upshifts" promotor_-10 226694..226712 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-10" promotor_-35 226728..226735 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 226750..226769 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 226750 /Source="Nicolas_upshifts" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 226757..227698 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15205417, 15375126, 21819557, 25666135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular glutamyl-endopeptidase" /protein_id="NP_388106.1" /db_xref="EnsemblGenomes-Gn:BSU02240" /db_xref="EnsemblGenomes-Tr:CAB12018" /db_xref="GOA:P39790" /db_xref="InterPro:IPR000126" /db_xref="InterPro:IPR001254" /db_xref="InterPro:IPR008256" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR018114" /db_xref="InterPro:IPR028301" /db_xref="SubtiList:BG10690" /db_xref="UniProtKB/Swiss-Prot:P39790" /translation="MKLVPRFRKQWFAYLTVLCLALAAAVSFGVPAKAAENPQTSVSN TGKEADATKNQTSKADQVSAPYEGTGKTSKSLYGGQTELEKNIQTLQPSSIIGTDERT RISSTTSFPYRATVQLSIKYPNTSSTYGCTGFLVNPNTVVTAGHCVYSQDHGWASTIT AAPGRNGSSYPYGTYSGTMFYSVKGWTESKDTNYDYGAIKLNGSPGNTVGWYGYRTTN SSSPVGLSSSVTGFPCDKTFGTMWSDTKPIRSAETYKLTYTTDTYGCQSGSPVYRNYS DTGQTAIAIHTNGGSSYNLGTRVTNDVFNNIQYWANQ*" /label="mpr CDS" gene 226757..227698 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /label="mpr gene" CDS 227661..228059 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388107.1" /db_xref="EnsemblGenomes-Gn:BSU02250" /db_xref="EnsemblGenomes-Tr:CAB12019" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR019730" /db_xref="SubtiList:BG12739" /db_xref="UniProtKB/Swiss-Prot:O31451" /translation="MYSTIFNIGQINKYSKLAIFMSILFLCGCSSQTHSSQKETTIPV TLHVEDAKGLPVEGVQVTIVKAPSSDEEPSTEIGEILGKTDKNGDIKWDTGRKGDYSV ALTKGETSVTHHISLTEDKKDHAIPLVFKE*" /label="ybfJ CDS" gene 227661..228059 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /label="ybfJ gene" promotor_-10 complement(227753..227767) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(227763) /Source="Nicolas_upshifts" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(227783..227788) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 228046 /Source="Nicolas_upshifts" /id="D85" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.50775" /MaxDrop="5.06025" /score="29.4582027" /energy="-15.4" /TU="U156" /idTUdmin="U157" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 228115..228122 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 228137..228156 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 228150..228224 /Source="Nicolas_S_feature" /locus_tag="new_246583_246657" /HighExp="Cold, LoTm, S0, aero, ferm, T-4.40H, nit, T-5.40H, T-0.40H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S87" upshifts 228150 /Source="Nicolas_upshifts" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" CDS 228225..229115 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11389736, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11389736, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enantioselective carboxylesterase" /protein_id="NP_388108.1" /db_xref="EnsemblGenomes-Gn:BSU02260" /db_xref="EnsemblGenomes-Tr:CAB12020" /db_xref="GOA:O31452" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:4CCY" /db_xref="SubtiList:BG12740" /db_xref="UniProtKB/Swiss-Prot:O31452" /translation="MIQDSMQFAAVESGLRFYQAYDQSLSLWPIESEAFYVSTRFGKT HIIASGPKDAPSLILLHGGLFSSAMWYPNIAAWSSQFRTYAVDIIGDKNKSIPSAAME TRADFAEWMKDVFDSLGLETAHLAGLSLGGSHIVNFLLRAPERVERAVVISPAEAFIS FHPDVYKYAAELTGARGAESYIKWITGDSYDLHPLLQRQIVAGVEWQDEQRSLKPTEN GFPYVFTDQELKSIQVPVLLMFGEHEAMYHQQMAFERASVLVPGIQAEIVKNAGHLLS LEQPEYVNQRVLSFLCGGIK*" /label="cesB CDS" gene 228225..229115 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /label="cesB gene" promotor_-35 228459..228466 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 228475 /Source="Nicolas_upshifts" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 228480..228498 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 229116..229310 /Source="Nicolas_S_feature" /locus_tag="new_247549_247743" /HighExp="Cold, LBGstat, Paraq, Oxctl, H2O2, dia15, G135, Diami, Lbexp, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.867, 1" /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S88" CDS 229311..229844 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /EC_number="2.7.8.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 15743965, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 15743965, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine synthase" /protein_id="NP_388109.1" /db_xref="EnsemblGenomes-Gn:BSU02270" /db_xref="EnsemblGenomes-Tr:CAB12021" /db_xref="GOA:P39823" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004533" /db_xref="SubtiList:BG11012" /db_xref="UniProtKB/Swiss-Prot:P39823" /translation="MNYIPCMITIGNFICGLLAIHSLLYHNIHSAVLFIFTGMFLDFF DGMAARKLNAVSDMGRELDSFADLVTFGVAPSMLAYSVALYTLPFIGILCALTYSICG MLRLSKFNIEQSKLPTFIGMPIPFAGMCLVILSFTYNPILLAIGTCGLSYLMVSKIKF PHFKKHAAENLESGRWN*" /label="pssA CDS" gene 229311..229844 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /label="pssA gene" CDS 229835..230323 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 14762009, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane phosphatase" /protein_id="NP_388110.1" /db_xref="EnsemblGenomes-Gn:BSU02280" /db_xref="EnsemblGenomes-Tr:CAB12022" /db_xref="GOA:O31453" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG12741" /db_xref="UniProtKB/Swiss-Prot:O31453" /translation="MELVQQLIADYGYLAIFLMLVLGIVGLPIPDEVMMTVVGYFTHT DVLNYELSILISFVGALLGMLISYMIGRKAGRPFIDKYGKWVGLKEKRMMKVEKWMKK YGPYSLILGYFIPGVRHVTCYFSGIGKMDLKTYVAFAAIGAFLWCFVFITIGRVIGII HV*" /label="ybfM CDS" gene 229835..230323 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /label="ybfM gene" CDS 230316..231107 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /EC_number="4.1.1.65" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 9422599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 9422599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine decarboxylase; 32 kDa precursor processed into a 29 kDa protein" /protein_id="NP_388111.1" /db_xref="EnsemblGenomes-Gn:BSU02290" /db_xref="EnsemblGenomes-Tr:CAB12023" /db_xref="GOA:P39822" /db_xref="InterPro:IPR003817" /db_xref="InterPro:IPR033177" /db_xref="InterPro:IPR033178" /db_xref="SubtiList:BG11013" /db_xref="UniProtKB/Swiss-Prot:P39822" /translation="MFNTAVKILYRSLIELTNHRLSSYLIKGFCESKISKPVIPLFSK HFRLNWDDVDGTAADYGSLSELFIRQINLERRPVSKEAHAVVSPVDGVVQTVGIINPN QTFTVKGKDYSFAELTGCKSADHQYNGGYFVVLYLSPRHYHRFHSPISCRYQKLAELG NRSYPVNQLGLKYGKDVLSKNYRFVYELNSGSRNVLMIPVGAMNINSIVQTNTRTELE IGEELGYFSFGSTVILVFEKDAFQPSAHLAEGQEVQVGELIGYEE*" /label="psd CDS" gene 230316..231107 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /label="psd gene" downshifts 231082 /Source="Nicolas_upshifts" /id="D86" /incds=0 /nref=101 /ntot=236 /MaxReadThrough="3.18138" /MaxDrop="4.25536" /score="-2.98360164" /energy="-8" /TU="U159" /idTUdmin="U160" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 231162..231440 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388112.1" /db_xref="EnsemblGenomes-Gn:BSU02300" /db_xref="EnsemblGenomes-Tr:CAB12024" /db_xref="SubtiList:BG12742" /db_xref="UniProtKB/Swiss-Prot:O31454" /translation="MEKQIISWITDYQNTGDEAVLRQVREVCWPIVEAVLQEKVMDDE QANNLREKGIERFPFIISKYQADVQLPVETFLQNTYRFYFHQVMRESS*" /label="ybfN CDS" gene 231162..231440 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /label="ybfN gene" promotor_-35 231483..231492 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 231501 /Source="Nicolas_upshifts" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 231505..231520 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 231546..232886 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_388113.1" /db_xref="EnsemblGenomes-Gn:BSU02310" /db_xref="EnsemblGenomes-Tr:CAB12025" /db_xref="GOA:O31455" /db_xref="InterPro:IPR007815" /db_xref="SubtiList:BG12743" /db_xref="UniProtKB/Swiss-Prot:O31455" /translation="MKRMIVRMTLPLLIVCLAFSSFSASARAASEEKYWDHWIERHAQ PLDASNASNKDLRFLKKVLKGKRIVQLGETTHGAGEINATKVRMIKYLHEELGYDVLA FESGFPDTNASYLNMDQLTPKSTMKNSIYAVWHTEDVVELFDYMKEQKEKGDPLILTG FDIQSMKNSFNVAATQWVKAVDPEKAELLSQSENDFSTLVTDSNTFDEFSQKKEKLVK NYQKLIKFTKTHASELKENLPKEPKAYEMFMHSLQLRIDVMETYMLEEMKEKLEEYPE NIEDFSFFMRDRMMAEQFQWVADTLYPKKKIIVWGHNYHLRKQNTKMIKDWVQLNGPN MGDYLPERLKKQTYTIGIYAYSGASLDSSDNKTVKPVTSPPPSGSLEALLKAADRPAV FVDFLHTKNKKGTSWMYTPRTALYWGYMEEQMILKEQYDGVIWLEHITPSVIIK*" /label="ybfO CDS" gene 231546..232886 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /label="ybfO gene" downshifts 232886 /Source="Nicolas_upshifts" /id="D87" /incds=0 /nref=12 /ntot=60 /MaxReadThrough="3.64301" /MaxDrop="6.34998" /score="14.4442651" /energy="-13.3" /TU="U161" /idTUdmin="U162" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" upshifts 232952 /Source="Nicolas_upshifts" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="upshifts" misc_feature 232955..232974 /Source="Nicolas_upshift_promotors" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 232994..233881 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388114.1" /db_xref="EnsemblGenomes-Gn:BSU02320" /db_xref="EnsemblGenomes-Tr:CAB12026" /db_xref="GOA:O31456" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12744" /db_xref="UniProtKB/Swiss-Prot:O31456" /translation="MYYEKAVQKTINWIESHLHEQISNEDIVNVSSFSKFHFHRIFQK EVGMSVASYIRLRRLANAAAALLYTDHRIIDIALYYQFESQEAFTRTFKKMYHMPPGA YRTFMKRFTSKKEESYMEKKMKGWVLSGSHPFQFEMGIDRENVHQGKASGYLKSTMVQ DIGEFATMMQQFKADRYLGKRLRLSSFIKTKGVQHFASLWMRVDSAADDVLQFDNMSN RPITGTTNWNHYAIVLDVPENSAVISFGVQLSGPGQVWMDHVVFEEVDESVPSTNLEM PGELLDEPVNLSFEEELQK*" /label="ybfP CDS" gene 232994..233881 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /label="ybfP gene" S_feature 233882..234025 /Source="Nicolas_S_feature" /locus_tag="new_252315_252458" /HighExp="T0.30H, T-1.40H, T0.0H, T-1.10H, Salt, aero, ferm, T-0.40H, T-2.40H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.838, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S89" promotor_-35 233997..234004 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 234018..234037 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 234027 /Source="Nicolas_upshifts" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 234081..235049 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with rhodanese domain" /protein_id="NP_388115.1" /db_xref="EnsemblGenomes-Gn:BSU02330" /db_xref="EnsemblGenomes-Tr:CAB12027" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR020936" /db_xref="InterPro:IPR022111" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG12745" /db_xref="UniProtKB/Swiss-Prot:O31457" /translation="MEKQYRVLLYYKYVPIEDPEAFREQHLAFCKELGLLGRILVSSE GINGTVSGTVEQTEKYMETMKADPRFADMVFKIDEAEGHAFKKIFVRHKKELVTLRLE DDVDPNETTGQHLKPAEFYEKMQDPNTIVIDARNDYEYDLGHFRGAVRPDIEAFRELP EWIEEHKDMLEGKKILTYCTGGVRCEKFSGWLVKQGFEDVAQLDGGIVTYGKDPEVQG KLWDGQCYVFDERISVPVNRVEHVIVGKDYFTGEPCERYVNCANPSCNKKMICTPENE YKYMRSCSHECRTNPRNLYVKEHNMTEEEVNARLAAIETEDHAAAE*" /label="ybfQ CDS" gene 234081..235049 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /label="ybfQ gene" promotor_-10 complement(234903..234921) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(234920) /Source="Nicolas_upshifts" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(234937..234942) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 235046 /Source="Nicolas_upshifts" /id="D88" /incds=0 /nref=238 /ntot=271 /MaxReadThrough="2.06825" /MaxDrop="7.49655" /score="4.11635522" /energy="-7.8" /TU="U163" /idTUdmin="U161" /TUdmin=4 /isTUend="TRUE" /label="downshifts" downshifts complement(235085) /Source="Nicolas_upshifts" /id="D89" /incds=0 /nref=59 /ntot=147 /MaxReadThrough="0.54212" /MaxDrop="6.33244" /score="2.56774646" /energy="-7.5" /TU="NA" /idTUdmin="U165" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(235085..236329) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7751298, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7751298, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/glutamate symport protein" /protein_id="NP_388116.1" /db_xref="EnsemblGenomes-Gn:BSU02340" /db_xref="EnsemblGenomes-Tr:CAB12028" /db_xref="GOA:P39817" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11015" /db_xref="UniProtKB/Swiss-Prot:P39817" /translation="MKKLIAFQILIALAVGAVIGHFFPDFGMALRPVGDGFIRLIKMI VVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVITTLVLGLGLLLANVLKPGVGLD LSHLAKKDIHELSGYTDKVVDFKQMILDIIPTNIIDVMARNDLLAVIFFAILFGVAAA GIGKASEPVMKFFESTAQIMFKLTQIVMVTAPIGVLALMAASVGQYGIELLLPMFKLV GTVFLGLFLILFVLFPLVGLIFQIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRME KYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFQVDMTLSQQLLMMLVLVMT SKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAIACIVV SKWEKAFRQKEWVSANSQTESI*" /label="gltP CDS" gene complement(235085..236329) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /label="gltP gene" promotor_-10 complement(236363..236381) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236372) /Source="Nicolas_upshifts" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(236392..236400) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(236400..236418) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236416) /Source="Nicolas_upshifts" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(236434..236439) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(236474..238369) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /EC_number="2.7.1.193" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10627040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucosamine-specific enzyme IICBA component" /protein_id="NP_388117.1" /db_xref="EnsemblGenomes-Gn:BSU02350" /db_xref="EnsemblGenomes-Tr:CAB12029" /db_xref="GOA:P39816" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11014" /db_xref="UniProtKB/Swiss-Prot:P39816" /translation="MFKKAFQILQQLGRALMTPVAVLPAAGLLLRFGDKDLLNIPIIK DAGGVVFDNLPLIFAVGVAIGLAGGEGVAGLAAVIGYLILTVTLDNMGKLLGLQPPYE GAEHLIDMGVFGGIIIGLLAAYLYKRFSSIELHPVLGFFSGKRFVPIITSVSSLVIGV IFSFVWPLIQNGINAASSLIADSTVGLFFYATIYRLLIPFGLHHIFYTPFYFMMGEYT DPSTGNTVTGDLTRFFAGDPTAGRFMMGDFPYMIFCLPAVALAIIHTARPEKKKMISG VMISAALTSMLTGITEPVEFSFLFVAPVLYLINSILAGVIFVVCDLFHVRHGYTFSGG GIDYVLNYGLSTNGWVVIPVGIVFAFIYYYLFRFAILKWNLKTPGRETDEDGQNEEKA PVAKDQLAFHVLQALGGQQNIANLDACITRLRVTVHQPSQVCKDELKRLGAVGVLEVN NNFQAIFGTKSDALKDDIKTIMAGGVPATAAALDTVTDKPLKPDSDETFIYPIKGETV SLGDVPDQVFSEKMMGEGFAIIPSEGKVVAPADGEIVSIFPTKHAIGFMSAGGTEILI HVGIDTVKLNGEGFEAHVTSGQAVKQGELLLTFDLNYIKQHAASAITPVIFTNTSEED LKHIQMK*" /label="gamP CDS" gene complement(236474..238369) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /label="gamP gene" downshifts complement(236490) /Source="Nicolas_upshifts" /id="D90" /incds=0 /nref=56 /ntot=192 /MaxReadThrough="1.9947" /MaxDrop="6.51864" /score="5.87664177" /energy="-12.1" /TU="NA" /idTUdmin="U168" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" misc_feature 238235..238254 /Source="Nicolas_upshift_promotors" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 238252 /Source="Nicolas_upshifts" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(238390..239139) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /EC_number="3.5.99.6" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:23667565, 27002132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 27002132; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate deaminase" /protein_id="NP_388118.1" /db_xref="EnsemblGenomes-Gn:BSU02360" /db_xref="EnsemblGenomes-Tr:CAB12030" /db_xref="GOA:O31458" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="SubtiList:BG12746" /db_xref="UniProtKB/Swiss-Prot:O31458" /translation="MKILIAEHYEELCKLSAAIIKEQIQAKKDAVLGLATGSTPVGLY KQLISDYQAGEIDFSKVTTFNLDEYAGLSPSHPQSYNHFMHEHLFQHINMQPDHIHIP QGDNPQLEAACKVYEDLIRQAGGIDVQILGIGANGHIGFNEPGSDFEDRTRVVKLSES TIQANARFFGGDPVLVPRLAISMGIKTIMEFSKHIVLLASGEEKADAIQKMAEGPVTT DVPASILQKHNHVTVIADYKAAQKLKSASFS*" /label="gamA CDS" gene complement(238390..239139) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /label="gamA gene" S_feature 239112..239293 /Source="Nicolas_S_feature" /locus_tag="new_257545_257726" /HighExp="H2O2, T1.30H, G135, dia15, G150, G180, LBGstat, T2.0H, T0.30H, M9-stat" /AntisenseName="nagBB" /AntisenseCor="0.458837556034909" /AntisenseRegPval="-14.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S90" S_feature complement(239140..239210) /Source="Nicolas_S_feature" /locus_tag="new_257573_257643_c" /HighExp="S1, Diami, MG 5, MG t5, dia5, MG 15, MG 10, LPhT, Paraq, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S91" promotor_-10 complement(239199..239218) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(239214) /Source="Nicolas_upshifts" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(239234..239241) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 239280..239287 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 239295 /Source="Nicolas_upshifts" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 239300..239319 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 239358..240065 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23667565, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator-GlcN6P (GntR family)" /protein_id="NP_388119.1" /db_xref="EnsemblGenomes-Gn:BSU02370" /db_xref="EnsemblGenomes-Tr:CAB12031" /db_xref="GOA:O31459" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12747" /db_xref="UniProtKB/Swiss-Prot:O31459" /translation="MTALYSVIKFKIIELIKSGKYQANDQLPTESEFCEQYDVSRTTV RLALQQLELEGYIKRIQGKGTFVSAAKIQTPIPHKITSFAEQMRGLRSESKVLELVVI PADHSIAELLKMKENEPVNKLVRVRYAEGEPLQYHTSYIPWKAAPGLAQEECTGSLFE LLRTKYNIEISRGTESIEPILTDETISGHLLTNVGAPAFLSESLTYDKNEEVVEYAQI ITRGDRTKFTVEQSYHS*" /label="gamR CDS" gene 239358..240065 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /label="gamR gene" promotor_-35 240031..240032 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240048..240062 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240058 /Source="Nicolas_upshifts" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="upshifts" CDS 240099..240374 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12897008, 23667565" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (B. subtilis-specific)" /protein_id="NP_388120.1" /db_xref="EnsemblGenomes-Gn:BSU02380" /db_xref="EnsemblGenomes-Tr:CAB12032" /db_xref="GOA:O31460" /db_xref="InterPro:IPR012867" /db_xref="SubtiList:BG12748" /db_xref="UniProtKB/Swiss-Prot:O31460" /translation="MFLFTNGKVLWGAVIAAFILSIVFYPFLPTQMPIHYDVANSPDL TVNKLAGTVMLPVLMVVFAWARKINWQFVFAVYILLICHIVVLCLAL*" /label="ybgB CDS" gene 240099..240374 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /label="ybgB gene" promotor_-10 complement(240157..240175) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(240163) /Source="Nicolas_upshifts" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(240190..240196) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 240366 /Source="Nicolas_upshifts" /id="D91" /incds=0 /nref=20 /ntot=130 /MaxReadThrough="2.42422" /MaxDrop="3.75723" /score="4.58454735" /energy="-9.4" /TU="NA" /idTUdmin="U169" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 240417..240421 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240437..240456 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240443 /Source="Nicolas_upshifts" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="upshifts" S_feature 240454..240582 /Source="Nicolas_S_feature" /locus_tag="new_258887_259015" /HighExp="T2.30H, S5, T2.0H, T1.30H, M9-stat, T3.0H, T3.30H, S4, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S92" CDS 240583..241653 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15060025, 15102328, 20332210, 23429746" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15060025, 15102328, 20332210, 23429746; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucine-valine aminotransferase / aromatic amino acid aminotransferase" /protein_id="NP_388121.1" /db_xref="EnsemblGenomes-Gn:BSU02390" /db_xref="EnsemblGenomes-Tr:CAB12033" /db_xref="GOA:O31461" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG12749" /db_xref="UniProtKB/Swiss-Prot:O31461" /translation="MNKLIEREKTVYYKEKPDPSSLGFGQYFTDYMFVMDYEEGIGWH HPRIAPYAPLTLDPSSSVFHYGQAVFEGLKAYRTDDGRVLLFRPDQNIKRLNRSCERM SMPPLDEELVLEALTQLVELEKDWVPKEKGTSLYIRPFVIATEPSLGVKASRSYTFMI VLSPVGSYYGDDQLKPVRIYVEDEYVRAVNGGVGFAKTAGNYAASLQAQRKANELGYD QVLWLDAIEKKYVEEVGSMNIFFVINGEAVTPALSGSILSGVTRASAIELIRSWGIPV REERISIDEVYAASARGELTEVFGTGTAAVVTPVGELNIHGKTVIVGDGQIGDLSKKL YETITDIQLGKVKGPFNWTVEV*" /label="ilvE CDS" gene 240583..241653 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /label="ilvE gene" downshifts 241642 /Source="Nicolas_upshifts" /id="D92" /incds=0 /nref=124 /ntot=245 /MaxReadThrough="1.34575" /MaxDrop="6.88046" /score="13.1364544" /energy="-9.4" /TU="NA" /idTUdmin="U172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(241690..243102) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid permease" /protein_id="NP_388122.1" /db_xref="EnsemblGenomes-Gn:BSU02400" /db_xref="EnsemblGenomes-Tr:CAB12034" /db_xref="GOA:O31462" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12750" /db_xref="UniProtKB/Swiss-Prot:O31462" /translation="MNSAHNKNETTFQRSMKSRHLFMLSLGGVIGTGLFLSSGYTIQQ AGPAGTILAYLVGAGIVYLVMLCLGELSVAMPVTGAFHTYAAKYIGPGTGFTVAWLYW LTWTVALGSEFTAAGLLMQRWFPHTSVWMWSAVFALFIFLLNAFSVKFFAESEFWFSS IKVLAIVLFILLGGSAMFGIIPIKGGEAAPMLSNFTAEGGLFPNGFVPILMTMLSVNF AFSGTELIGIAAGESVDPDKTIPKAIKTTVWRLSLFFVGTIFVLSGLIPIQDAGVIKS PFVAVFDRVGVPYAADIMNFVILTAILSAANSGLYASSRMLWSLSKEKTLHPTFAKLT SKGTPFNALVFSMIGGILSLLSSVFAPDTVYVVLVSISGFAVVVVWMGIAASQFMFRK RYIEAGNKVTDLKYRTPLYPFVPIAAFLLCLASVVGIAFDPNQRIALYCGVPFMAICY AIYYVKNRKSQPAADMTHSK*" /label="ybgF CDS" gene complement(241690..243102) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /label="ybgF gene" downshifts complement(241707) /Source="Nicolas_upshifts" /id="D93" /incds=0 /nref=43 /ntot=166 /MaxReadThrough="0.37503" /MaxDrop="5.92001" /score="6.94246417" /energy="-9.4" /TU="NA" /idTUdmin="U173" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(243103..243214) /Source="Nicolas_S_feature" /locus_tag="new_261536_261647_c" /HighExp="BMM, S1, MG 45, MG 60, UNK1, MG t5, MG 10, MG 90, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S93" promotor_-10 complement(243187..243206) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(243214) /Source="Nicolas_upshifts" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(243221..243228) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(243223..244170) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11267663, 15995196, 17264075; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homocysteine methylase using (R,S)AdoMet" /protein_id="NP_388123.1" /db_xref="EnsemblGenomes-Gn:BSU02410" /db_xref="EnsemblGenomes-Tr:CAB12035" /db_xref="GOA:O31463" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR017226" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG12751" /db_xref="UniProtKB/Swiss-Prot:O31463" /translation="MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEE PELIKQVHTDYFAAGADCAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDE FWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEA GADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDE HRQIAALGINCTPLQHIPSLIEELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESY GASARTWHEKGARLIGGCCRTKPENIQEIAAWARSLKTT*" /label="ybgG CDS" gene complement(243223..244170) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /label="ybgG gene" promotor_-10 complement(244208..244227) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-10" upshifts complement(244225) /Source="Nicolas_upshifts" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="upshifts" promotor_-35 complement(244242..244249) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-35" CDS complement(244299..245735) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 15995196, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine transporter" /protein_id="NP_388124.2" /db_xref="EnsemblGenomes-Gn:BSU02420" /db_xref="EnsemblGenomes-Tr:CAB12036" /db_xref="GOA:O31464" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12752" /db_xref="UniProtKB/Swiss-Prot:O31464" /translation="MQQILEHIVGIANDLLWSKLLIVLLLSFGIYFTFRLKFLQVRML KEMVRVLREGAASRSKNSISPFQAFCISMAARVGTGNITGIAIAIALGGPGAIFWMWI IAIIGSASSFVESTLAQIYKVKDVNGFRGGPAYYMEKGLNKRWMGALFAVLITLSFGI VFNSVQSNTVSLAFENAFGTNRLTLGLILIAVFGTIIFGGVKRIAKLAESIVVVLAVL YIGVAFFVIFSNITQLPGVLALIVKNAFGFDQAAGGALGAALMQGVRRGIFSNEAGMG SAPNAAATATTSHPVKQGLIQAFGVLTDTLVICTSTAFIILFSDAYHTPGLSGIALTQ ASLSSHVGSWASGFLAILILLFGFCALIGNYYYGETNIGFLNKSKKLIFVYRIGVLAM IVFGCVAKVQLVWDLADLFMGLMVIVNLIAIFLLSKVVFTALKDYTRQKKAGKDPVFY KDVLKNHNGIECWPVSDTKTDTHNKQIS*" /label="glnT CDS" gene complement(244299..245735) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /label="glnT gene" downshifts complement(244314) /Source="Nicolas_upshifts" /id="D94" /incds=0 /nref=3 /ntot=3 /MaxReadThrough="0.598370000000001" /MaxDrop="4.3935" /score="-7.90227391" /energy="-11.4" /TU="NA" /idTUdmin="U174" /TUdmin="-1078" /isTUend="FALSE" /label="downshifts" CDS complement(245758..246741) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15995196, 18459799, 20050917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995196, 18459799, 20050917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutaminase" /protein_id="NP_388125.1" /db_xref="EnsemblGenomes-Gn:BSU02430" /db_xref="EnsemblGenomes-Tr:CAB12037" /db_xref="GOA:O31465" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="PDB:1MKI" /db_xref="PDB:2OSU" /db_xref="PDB:3AGF" /db_xref="PDB:3BRM" /db_xref="SubtiList:BG12753" /db_xref="UniProtKB/Swiss-Prot:O31465" /translation="MKELIKEHQKDINPALQLHDWVEYYRPFAANGQSANYIPALGKV NDSQLGICVLEPDGTMIHAGDWNVSFTMQSISKVISFIAACMSRGIPYVLDRVDVEPT GDAFNSIIRLEINKPGKPFNPMINAGALTIASILPGESAYEKLEFLYSVMETLIGKRP RIHEEVFRSEWETAHRNRALAYYLKETNFLEAEVEETLEVYLKQCAMESTTEDIALIG LILAHDGYHPIRHEQVIPKDVAKLAKALMLTCGMYNASGKYAAFVGVPAKSGVSGGIM ALVPPSARREQPFQSGCGIGIYGPAIDEYGNSLTGGMLLKHMAQEWELSIF*" /label="glsA CDS" gene complement(245758..246741) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /label="glsA gene" promotor_-10 complement(246835..246852) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 246840..246859 /Source="Nicolas_upshift_promotors" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(246842) /Source="Nicolas_upshifts" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 246846 /Source="Nicolas_upshifts" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(246868..246875) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 247043..248275 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196, 17001076, 21435182, 23461034, 25691471; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [GlnL] forglutamine degradation" /protein_id="NP_388126.2" /db_xref="EnsemblGenomes-Gn:BSU02440" /db_xref="EnsemblGenomes-Tr:CAB12038" /db_xref="GOA:P40758" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10871" /db_xref="UniProtKB/Swiss-Prot:P40758" /translation="MLITVPLAGELKFYPLNEEFRVSFGAPVFFFFLSLLRHVPAVLP GFLTGAAVFIFRVFLELWGGGHNGLTPILYDQASGFFFYMTYACLFSILKANRFRERP IMLGFIGFMIEVVSDCVELTVQFLIFHTVVTPEKITDIAVIAISHTFIVMSFYSVLKL YETQSREKQTRQQHEHMLMIVSNLYEETVHLKKTLKTTEKVTNDSYQLYREMKGKDVQ LSGRILRLAGEIHEVKKDNQRIFAGLSKLISNESLRDYMRASDLLQLVIRMNEKYAEA LGKQIDFYCSIEGEHDEYHVFIVLSIINNLTANAVEAMDEEGMVSLRLRKPNESMVEF QVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQ RGVVFAIRLPVRHLIQKG*" /label="glnJ CDS" gene 247043..248275 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /label="glnJ gene" CDS 248286..249230 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [GlnJ] for glutamine utilisation" /protein_id="NP_388127.1" /db_xref="EnsemblGenomes-Gn:BSU02450" /db_xref="EnsemblGenomes-Tr:CAB12039" /db_xref="GOA:P40759" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013972" /db_xref="SubtiList:BG10872" /db_xref="UniProtKB/Swiss-Prot:P40759" /translation="MRFFIADDDRAVRSILRQIIEDEDLGEAAGEADDGSQVEGHMLQ FKQIDILLIDLLMPGRDGIETIRQIQNTYSGKIVMISQVEAKEMVGEAYSLGIEYFIH KPINRIEIVTVLQKVKERIELEHSIGAIQHSLSRLVNRTERKARPQQKSDSGLKEAGT FLLSELGMMGEGGAHDLMAVLQYLAEHEQSEPHEKQSPSLKQIFTQVAVRKLGTGASQ TEVNREMKASEQRIRRAIIHSLHHFASLGTTDFSNPKFETYASKFFDFPVVSQKMKEL QSKDAKPLAPARINMKKFIHVFFLEAKLLHETMKQRRI*" /label="glnL CDS" gene 248286..249230 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /label="glnL gene" downshifts 249207 /Source="Nicolas_upshifts" /id="D95" /incds=0 /nref=45 /ntot=191 /MaxReadThrough="1.43757" /MaxDrop="3.64091" /score="2.73020459" /energy="-6.2" /TU="NA" /idTUdmin="U177" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" promotor_-35 249327..249334 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 249339..249456 /Source="Nicolas_S_feature" /locus_tag="new_267772_267889" /HighExp="Sw, BC, M40t90, Etha, MG-0.2, HiTm, HiOs, G135, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S94" upshifts 249339 /Source="Nicolas_upshifts" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 249348..249367 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 249457..250383 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /EC_number="4.2.1.41" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5-dehydro-4-deoxyglucarate dehydratase" /protein_id="NP_388128.2" /db_xref="EnsemblGenomes-Gn:BSU02460" /db_xref="EnsemblGenomes-Tr:CAB12040" /db_xref="GOA:P42235" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017655" /db_xref="SubtiList:BG11158" /db_xref="UniProtKB/Swiss-Prot:P42235" /translation="MSRIRKAPAGILGFPVAPFNTQGKLEEEALFQNIEFLLNEGLEA IFIACGSGEFQSLSQKEYEQMVEVAVSAAGGKVPVYTGVGGNLSTALDWAQLSEKKGA DGYLILPPYLVHGEQEGLYQYAKTIIESTDLNAILYQRDNAVLSVEQIKRLTECEQLV GVKDGVGNMDLNINLVYTIGDRLGWLNGMPMAEVTMPAYLPIGFHSYSSAISNYIPHI SRMFYDALKNGNDELVKELYRHVILPINDIRKQRKGYAVSLIKAGMEIMGLNVRNTAR PPVGPVEKDHYQQLEAILKQAADRFPKKAATV*" /label="kdgD CDS" gene 249457..250383 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /label="kdgD gene" CDS 250413..251879 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /EC_number="1.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674, 17202142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,5-dioxovalerate dehydrogenase (alpha-ketoglutaric semialdehyde dehydrogenase)" /protein_id="NP_388129.1" /db_xref="EnsemblGenomes-Gn:BSU02470" /db_xref="EnsemblGenomes-Tr:CAB12041" /db_xref="GOA:P42236" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11159" /db_xref="UniProtKB/Swiss-Prot:P42236" /translation="MSVITEQNTYLNFINGEWVKSQSGDMVKVENPADVNDIVGYVQN STAEDVERAVTAANEAKTAWRKLTGAERGQYLYKTADIMEQRLEEIAACATREMGKTL PEAKGETARGIAILRYYAGEGMRKTGDVIPSTDKDALMFTTRVPLGVVGVISPWNFPV AIPIWKMAPALVYGNTVVIKPATETAVTCAKIIACFEEAGLPAGVINLVTGPGSVVGQ GLAEHDGVNAVTFTGSNQVGKIIGQAALARGAKYQLEMGGKNPVIVADDADLEAAAEA VITGAFRSTGQKCTATSRVIVQSGIYERFKEKLLQRTKDITIGDSLKEDVWMGPIASK NQLDNCLSYIEKGKQEGASLLIGGEKLENGKYQNGYYVQPAIFDNVTSEMTIAQEEIF GPVIALIKVDSIEEALNIANDVKFGLSASIFTENIGRMLSFIDEIDAGLVRINAESAG VELQAPFGGMKQSSSHSREQGEAAKDFFTAIKTVFVKP*" /label="gucD CDS" gene 250413..251879 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /label="gucD gene" CDS 251963..253330 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12044674, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucarate transporter" /protein_id="NP_388130.2" /db_xref="EnsemblGenomes-Gn:BSU02480" /db_xref="EnsemblGenomes-Tr:CAB12042" /db_xref="GOA:P42237" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11160" /db_xref="UniProtKB/Swiss-Prot:P42237" /translation="MKKDFASVTPAGKKTSVRWFIVFMLFLVTSINYADRATLSITGD SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQ GAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY FAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYI EQGGGLISMDDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVY LVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLL SCSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGN IASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLLVGPIKRVVLKKQEQDPD QSLPV*" /label="gudP CDS" gene 251963..253330 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /label="gudP gene" CDS 253367..254734 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /EC_number="4.2.1.40" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772161, 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucarate dehydratase" /protein_id="NP_388131.2" /db_xref="EnsemblGenomes-Gn:BSU02490" /db_xref="EnsemblGenomes-Tr:CAB12043" /db_xref="GOA:P42238" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR017653" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR034598" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11161" /db_xref="UniProtKB/Swiss-Prot:P42238" /translation="MSSPIQEQVQKEKRSNIPSISEMKVIPVAGHDSMLLNLSGAHSP FFTRNIVILTDSSGNQGVGEVPGGEHIRRTLELSEPLVVGKSIGAYQAILQTVRKQFG DQDRGGRGNQTFDLRTTVHAVTALEAALLDLLGKFLQEPVAALLGEGKQRDEVKMLGY LFYIGDRNRTTLPYQSDEQSDCAWFRLRHEEALTPEAIVRLAESAQERYGFQDFKLKG GVLRGEEEIEAVTALSKRFPEARITLDPNGAWSLEEAIALCKGKQDVLAYAEDPCGDE NGYSAREVMAEFRRATGLPTATNMIATDWREMGHAIQLHAVDIPLADPHFWTMQGSVR VAQMCHDWGLTWGSHSNNHFDISLAMFTHVAAAAPGRITAIDTHWIWQDGQRLTKQPF EISSGCVKVPDKPGLGVDIDMEQVEKAHEIYRKMNLGARNDAIPMQFLISNWEFDRKR PCLVR*" /label="gudD CDS" gene 253367..254734 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /label="gudD gene" promotor_-35 254748..254755 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-35" promotor_-10 254770..254787 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-10" upshifts 254773 /Source="Nicolas_upshifts" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="upshifts" CDS 254804..255505 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12044674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388132.2" /db_xref="EnsemblGenomes-Gn:BSU02500" /db_xref="EnsemblGenomes-Tr:CAB12044" /db_xref="GOA:P42239" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11162" /db_xref="UniProtKB/Swiss-Prot:P42239" /translation="MYEGLEDLKVDTVNRKTLAKQVIERIVHLLSSGQLRAGDKLPTE MELMDILHVSRPVLREALSSLETLGVITRKTRGGTYFNDKIGMQPFSVMLALATDNLP AIIEARMALELGLVTIAAEKINEEELQRLQKTIDDIANSTDNHYGEADKEFHRIIALS ANNPVVEGMIQSLLITHAKIDSQIPYRERDVTVEYHKKIYDALAKRDPYKAHYHMYEH LKFVRDKILKGMDEK*" /label="garR CDS" gene 254804..255505 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /label="garR gene" downshifts 255455 /Source="Nicolas_upshifts" /id="D96" /incds=0 /nref=1 /ntot=35 /MaxReadThrough="3.59234" /MaxDrop="2.3923" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" downshifts 255499 /Source="Nicolas_upshifts" /id="D97" /incds=0 /nref=1 /ntot=82 /MaxReadThrough="3.21794" /MaxDrop="2.49226" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS 255596..257128 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /EC_number="4.2.1.42" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772162; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-galactarate dehydratase" /protein_id="NP_388133.2" /db_xref="EnsemblGenomes-Gn:BSU02510" /db_xref="EnsemblGenomes-Tr:CAB12045" /db_xref="GOA:P42240" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR017654" /db_xref="SubtiList:BG11163" /db_xref="UniProtKB/Swiss-Prot:P42240" /translation="MAMNLRKNQAPLYIKVHEIDNTAIIVNDGGLPKGTVFSCGLVLE EDVPQGHKVALTDLNQGDEIVRYGEVIGFADETIKRGSWIREALVRMPAPPALDDLPL ANRVPQPRPPLEGYTFEGYRNADGSAGTKNILGITTSVQCVVGVLDYAVKRIKEELLP KYPNVDDVVPLHHQYGCGVAINAPDAVIPIRTIQNLAKHPNFGGEVMVIGLGCEKLLP ERIASENDDDILSLQDHRGFAAMIQSILEMAEERLIRLNSRTRVSCPVSDLVIGLQCG GSDAFSGVTANPAVGYAADLLVRAGATVLFSEVTEVRDAIHLLTPRAVSEEVGQSLIK EMKWYDSYLRRGDADRSANPSPGNKKGGLSNVVEKALGSVAKSGTSPISGVLGPGERA KQKGLLFAATPASDFVCGTLQLAAGMNLQVFTTGRGTPYGLAAAPVLKVSTRHSLSEH WADLIDINAGRIATGEASIEDVGWEIFRTILDVASGRKQTWADRWGLHNDLCLFNPAP VT*" /label="garD CDS" gene 255596..257128 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /label="garD gene" promotor_-35 257140..257143 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 257158..257177 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 257170..257404 /Source="Nicolas_S_feature" /locus_tag="new_275603_275837" /HighExp="LoTm, Sw, BC, BI, B60, B36, T3.30H, T5.0H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.50265400000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S95" upshifts 257170 /Source="Nicolas_upshifts" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 257405..258325 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_388134.1" /db_xref="EnsemblGenomes-Gn:BSU02520" /db_xref="EnsemblGenomes-Tr:CAB12046" /db_xref="GOA:P42242" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG11165" /db_xref="UniProtKB/Swiss-Prot:P42242" /translation="MTNLNEKQLITEIVGLARSQGLTVHSENAQLNETGMDFQVVFAK DDTGMPWVLRKPRRSDVVERASAEGITLAFLRANLTADVPDWRIHTPELIAYPMLKGT PAAGIDLEQKQYVWNMDHQPPSDDFVRTLADILAELHGTDQISAGQSGIEVIRPEDFR QMTADSMVDVKNKLGVSTTLWERWQKWVDDDAYWPGFSSLIHGDLHPPHILIDQNGRV TGLLDWTEAKVADPAKDFVLYQTIFGEKETARLLEYYDQAGGRIWAKMQEHISEMQAA YPVEIAKLALQTQQEEHINMALEALGVTSD*" /label="ycbJ CDS" gene 257405..258325 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /label="ycbJ gene" promotor_-35 258327..258334 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 258349..258368 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 258359 /Source="Nicolas_upshifts" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 258382..258629 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /product="T-box riboswitch specific of tryptophan tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 10706627, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 10706627, 12165569, 12547201; Product type n: RNA" /label="tboW RNA" gene 258382..258629 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /label="tboW gene" downshifts 258598 /Source="Nicolas_upshifts" /id="D98" /incds=0 /nref=225 /ntot=264 /MaxReadThrough="2.36361" /MaxDrop="6.52913" /score="36.5571172" /energy="-16.6" /TU="NA" /idTUdmin="U179" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS 258727..258888 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-TRAP regulator" /protein_id="NP_388135.1" /db_xref="EnsemblGenomes-Gn:BSU02530" /db_xref="EnsemblGenomes-Tr:CAB12047" /db_xref="GOA:O31466" /db_xref="InterPro:IPR031538" /db_xref="InterPro:IPR036410" /db_xref="PDB:2BX9" /db_xref="PDB:2KO8" /db_xref="PDB:2ZP8" /db_xref="PDB:2ZP9" /db_xref="SubtiList:BG12776" /db_xref="UniProtKB/Swiss-Prot:O31466" /translation="MVIATDDLEVACPKCERAGEIEGTPCPACSGKGVILTAQGYTLL DFIQKHLNK*" /label="rtpA CDS" gene 258727..258888 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /label="rtpA gene" promotor_no_box 258805..258905 /Source="Nicolas_upshift_promotors" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 258865 /Source="Nicolas_upshifts" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 258909..259847 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10706627, 15063849, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative tryptophan or indole exporter" /protein_id="NP_388136.1" /db_xref="EnsemblGenomes-Gn:BSU02540" /db_xref="EnsemblGenomes-Tr:CAB12048" /db_xref="GOA:P42243" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG11166" /db_xref="UniProtKB/Swiss-Prot:P42243" /translation="MRAEEQSKIREAAAGTIFLLIGTVCFASKSIWIKWAYQMGAEPD AVLLYRQLLAVPLFWLIFLIYRPPMPDGKKKGDLWKACGAGVFCFFLSPLLDFIGLNH VSAMVERILLMSYPLFVFGFTACRDRKMSSIQDLFAVLAVMFGLFLALGGWNAELFQA NMIGAVFILLSSAVYAGYLVLSGHLVHQIGGIRLNAYGMTAAGAAMMLYTGIKSAAGM NTPMAAYPLSMYGLFAVIAVVTTVIPFVLMLEGIKRIGAQRAAAISMAGPILTIFYGA LFLGERLGLIQVIGCGGVFFVITGMEYRKLKTGKKE*" /label="ycbK CDS" gene 258909..259847 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /label="ycbK gene" downshifts 258953 /Source="Nicolas_upshifts" /id="D99" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="3.05417" /MaxDrop="3.72787" /score="0.773303272" /energy="-9" /TU="NA" /idTUdmin="U181" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 259870..259889 /Source="Nicolas_upshift_promotors" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 259875..259943 /Source="Nicolas_S_feature" /locus_tag="new_278308_278376" /HighExp="C90, dia5, Lbtran, Lbexp, LBGexp, SMM, dia0, dia15, BMM, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S96" upshifts 259875 /Source="Nicolas_upshifts" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="upshifts" CDS 259944..260624 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YcbM]" /protein_id="NP_388137.2" /db_xref="EnsemblGenomes-Gn:BSU02550" /db_xref="EnsemblGenomes-Tr:CAB12049" /db_xref="GOA:P42244" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11167" /db_xref="UniProtKB/Swiss-Prot:P42244" /translation="MLVEDDHSISEMVDHYLTKEGFGIVHAFDGEEGIRLFQQGSYDL VLLDIMLPKLNGMDFLKIIREKSNIPVLMISAKDGDVDKALGLGFGADDYIAKPFSMI ELTARVKAAIRRATQYSAEEPAVNKVIRIHQLAIDIDNVSVLKNGEPLQLTSTEWQLL CLFASNPKKVFTKEQIYRSVWNEEYFDDQNIINVHMRRLREKIEDDPSSPQYIKTLWG IGYKLGEF*" /label="ycbL CDS" gene 259944..260624 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /label="ycbL gene" CDS 260626..261561 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YcbL]" /protein_id="NP_388138.2" /db_xref="EnsemblGenomes-Gn:BSU02560" /db_xref="EnsemblGenomes-Tr:CAB12050" /db_xref="GOA:P42245" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11168" /db_xref="UniProtKB/Swiss-Prot:P42245" /translation="MTVLWVAAVIALACLNVIQFIMKKKRDGNLAYTADQLSYMLSRD SAGQILLPTDDHALKDLLVNINLIVENRQQISAQFAKTEQSMKRMLTNMSHDLKTPLT VILGYIEAIQSDPNMPDEERERLLGKLRQKTNELIQMINSFFDLAKLESEDKEIPITK VHMNDICKRNILHYYDAVQSKGFQAAIDIPDTPVYAQANEEALDRILQNLLSNAIQYG AAGKLIGLTLSYDERNIAITVWDRGKGISETDQQRVFERLYTLEESRNKAFQGSGLGL TITKRLTEKMGGIISVQSKPYERTAFTITLKRMTY*" /label="ycbM CDS" gene 260626..261561 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /label="ycbM gene" CDS 261653..262576 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388139.2" /db_xref="EnsemblGenomes-Gn:BSU02570" /db_xref="EnsemblGenomes-Tr:CAB12051" /db_xref="GOA:P42246" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11169" /db_xref="UniProtKB/Swiss-Prot:P42246" /translation="MTYIVQTNGLTKTYQGKEVVSNVSMHIKKGEIYGFLGPNGAGKT TIMKMLTSLVKPTSGEIIILGNKFTHTSYEVLGNIGSMIEYPIFYENLTAEENLDLHC EYMGYHNKKAIQEVLDMVNLKQIDKKPVKTFSLGMKQRLGIARAILTKPDLLILDEPV NGLDPLGIKKIRQLFQVLSKEYGMTLLISSHLLGEIEQIADTIGVIRDGRLLEEVSME DVRGQNTEYIELVTPNQTRACFVLEKELQLTNFKILNEKTIRIYEAEASQAAISKALI LNDVDIESMNKKYTSLEDYFIKLINGNSISA*" /label="ycbN CDS" gene 261653..262576 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /label="ycbN gene" S_feature complement(262123..263307) /Source="Nicolas_S_feature" /locus_tag="new_280556_281740_c" /HighExp="Etha, Sw, Gly, B36, LoTm, B60, GM 150, Salt, C30, ferm" /AntisenseName="ycbO" /AntisenseCor="-0.38911425676406203" /AntisenseRegPval="-10.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S97" CDS 262595..263281 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven exporter" /protein_id="NP_388140.3" /db_xref="EnsemblGenomes-Gn:BSU02580" /db_xref="EnsemblGenomes-Tr:CAB12052" /db_xref="GOA:P42247" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11170" /db_xref="UniProtKB/Swiss-Prot:P42247" /translation="MNLIRIELRKMKMGWYIRGALIANVIIMGFMWLISYSEKADGGV SFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVISEYKNKTILVMFTYPISRKKLLTAK LMIAGGLTFITILLSNILIAAGFFWLNSICHFIPGELTSEIISQQAVKMAVFAFGAAG TSLVPIFFGMRRHSVPATIISSVVIVMLISSTSPGFSISSVVYIPLSLAAFGLFFSYM AIRNADKQDA*" /label="ycbO CDS" gene 262595..263281 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /label="ycbO gene" CDS complement(263242..263376) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513940.1" /translation="MARSIILKQEQTHNGKAGADSIGLLYILGAFVYASCLSAFLIAM *" /label="hypothetical protein CDS" gene complement(263242..263376) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /label="gene" downshifts 263276 /Source="Nicolas_upshifts" /id="D100" /incds=0 /nref=8 /ntot=120 /MaxReadThrough="1.13131" /MaxDrop="3.44039" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" CDS complement(263336..263722) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22582280; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative inner integral membrane protein" /protein_id="NP_388141.1" /db_xref="EnsemblGenomes-Gn:BSU02590" /db_xref="EnsemblGenomes-Tr:CAB12053" /db_xref="GOA:P42248" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG11171" /db_xref="UniProtKB/Swiss-Prot:P42248" /translation="MTHVKALAIKGIMTIIVLYLVLGLGFGFTFGDTLLMTIVLGVIS YLLGDLYVLPKWNNMIATLADFGLAFLVIWLMGMPLSMGMTGGEVALAALFGAIVMAI GEYCFHFYMMSKEIGKKHYLETRTDS*" /label="ycbP CDS" gene complement(263336..263722) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /label="ycbP gene" downshifts complement(263352) /Source="Nicolas_upshifts" /id="D101" /incds=0 /nref=148 /ntot=217 /MaxReadThrough="6.64196" /MaxDrop="7.40353" /score="13.8182557" /energy="-15.6" /TU="U183" /idTUdmin="U185" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(263748..263766) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(263767) /Source="Nicolas_upshifts" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(263780..263786) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(263800..264798) /Source="Nicolas_S_feature" /locus_tag="new_282233_283231_c" /HighExp="GM 150, T0.30H, C30, T1.30H, T1.0H, T-0.40H, T-3.40H, T2.0H, T2.30H, T-4.40H" /AntisenseName="cwlJ" /AntisenseCor="0.11463160303596701" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S98" downshifts complement(263843) /Source="Nicolas_upshifts" /id="D102" /incds=0 /nref=3 /ntot=10 /MaxReadThrough="5.23914" /MaxDrop="3.14515" /score="13.8182557" /energy="-15.6" /TU="U185,U187" /idTUdmin="U185" /TUdmin="-491" /isTUend="FALSE" /label="downshifts" promotor_-35 263979..263984 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 263998 /Source="Nicolas_upshifts" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 264000..264018 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264012) /Source="Nicolas_upshifts" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(264014..264028) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(264034) /Source="Nicolas_upshifts" /id="D103" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="5.64474" /MaxDrop="3.76775" /score="13.8182557" /energy="-15.6" /TU="U187" /idTUdmin="U185" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 complement(264036..264040) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 264036..264464 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore cortex cell wall hydrolase" /protein_id="NP_388142.2" /db_xref="EnsemblGenomes-Gn:BSU02600" /db_xref="EnsemblGenomes-Tr:CAB12054" /db_xref="GOA:P42249" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG11172" /db_xref="UniProtKB/Swiss-Prot:P42249" /translation="MAVVRATSADVDLMARLLRAEAEGEGKQGMLLVGNVGINRLRAN CSDFKGLRTIRQMIYQPHAFEAVTHGYFYQRARDSERALARRSINGERRWPAKFSLWY FRPQGDCPAQWYNQPFVARFKSHCFYQPTAETCENVYNTF*" /label="cwlJ CDS" gene 264036..264464 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /label="cwlJ gene" downshifts 264443 /Source="Nicolas_upshifts" /id="D104" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.30044" /MaxDrop="5.89045" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 264509..264515 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 264528..264547 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 264530 /Source="Nicolas_upshifts" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="upshifts" CDS 264570..265301 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388143.2" /db_xref="EnsemblGenomes-Gn:BSU02610" /db_xref="EnsemblGenomes-Tr:CAB12055" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR019303" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG11173" /db_xref="UniProtKB/Swiss-Prot:P42250" /translation="MATIDLQKKSVKIVLEKKQLTKVTARVGLVLDITGSMRPLYKNG TVQNVVERILAVADQFDDNGLLDVWVYDNEFSRLKPVSEKDFSGYVDREILNNDRLHK FGRNDEPPVMKDVLRKYVTEEPSSYPAFIVFINDGGCKKSIKPIIEASSDKPVFWQFV GIGNGNFDFLNKLDTLEGRVIDNTNFLHIEEIDRISDDELYDALLAEFPFWLKEAKEK GIVREQEPPAEKPKKKGFFSRLFSK*" /label="ycbR CDS" gene 264570..265301 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /label="ycbR gene" promotor_-10 complement(264772..264791) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264798) /Source="Nicolas_upshifts" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(264805..264812) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 265219 /Source="Nicolas_upshifts" /id="D105" /incds=1 /nref=9 /ntot=148 /MaxReadThrough="1.70712" /MaxDrop="3.61288" /score="25.6672471" /energy="-14.1" /TU="NA" /idTUdmin="U186" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 265383..265559 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097673.1" /db_xref="EnsemblGenomes-Gn:BSU02619" /db_xref="EnsemblGenomes-Tr:CAX52543" /db_xref="UniProtKB/Swiss-Prot:C0H3T2" /translation="MGGLQTTGYAENASFSQLSACFSSRLVREDLFLMFSAYNQFTLL HSRLTMISYNGDDQ*" /label="yczK CDS" gene 265383..265559 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /label="yczK gene" promotor_-35 265511..265517 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 265524..265541 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 265535 /Source="Nicolas_upshifts" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="upshifts" CDS 265578..267329 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted phosphodiesterase (endo-hydrolysis at non-specific sites throughout the cell wall teichoic acid polymer)" /protein_id="NP_388144.2" /db_xref="EnsemblGenomes-Gn:BSU02620" /db_xref="EnsemblGenomes-Tr:CAB12056" /db_xref="GOA:P42251" /db_xref="InterPro:IPR008963" /db_xref="InterPro:IPR018946" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR032093" /db_xref="PDB:2YEQ" /db_xref="SubtiList:BG11174" /db_xref="UniProtKB/Swiss-Prot:P42251" /translation="MAYDSRFDEWVQKLKEESFQNNTFDRRKFIQGAGKIAGLSLGLT IAQSVGAFEVNAAPNFSSYPFTLGVASGDPLSDSVVLWTRLAPDPLNGGGMPKQAVPV KWEVAKDEHFRKIVRKGTEMAKPSLAHSVHVEADGLEPNKVYYYRFKTGHELSPVGKT KTLPAPGANVPQMTFAFASCQQYEHGYYTAYKHMAKEKLDLVFHLGDYIYEYGPNEYV SKTGNVRTHNSAEIITLQDYRNRHAQYRSDANLKAAHAAFPWVVTWDDHEVENNYANK IPEKGQSVEAFVLRRAAAYQAYYEHMPLRISSLPNGPDMQLYRHFTYGNLASFNVLDT RQYRDDQANNDGNKPPSDESRNPNRTLLGKEQEQWLFNNLGSSTAHWNVLAQQIFFAK WNFGTSASPIYSMDSWDGYPAQRERVINFIKSKNLNNVVVLTGDVHASWASNLHVDFE KTSSKIFGAEFVGTSITSGGNGADKRADTDQILKENPHIQFFNDYRGYVRCTVTPHQW KADYRVMPFVTEPGAAISTRASFVYQKDQTGLRKVSSTTIQGGVKQSDEVEEDRFFSH NKAHEKQMIKKRAKITN*" /label="phoD CDS" gene 265578..267329 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /label="phoD gene" promotor_-10 complement(265632..265647) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(265638) /Source="Nicolas_upshifts" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(265660..265669) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 267342..267554 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867413, 15554971, 16678787, 19049517, 21479530, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867413, 15554971, 16678787, 19049517, 21479530, 27984091; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388145.2" /db_xref="EnsemblGenomes-Gn:BSU02630" /db_xref="EnsemblGenomes-Tr:CAB12057" /db_xref="GOA:O31467" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR003998" /db_xref="InterPro:IPR006312" /db_xref="PDB:2L16" /db_xref="SubtiList:BG12777" /db_xref="UniProtKB/Swiss-Prot:O31467" /translation="MFSNIGIPGLILIFVIALIIFGPSKLPEIGRAAGRTLLEFKSAT KSLVSGDEKEEKSAELTAVKQDKNAG*" /label="tatAD CDS" gene 267342..267554 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /label="tatAD gene" S_feature 267555..267614 /Source="Nicolas_S_feature" /locus_tag="new_285988_286047" /HighExp="LPhT, BI, Paraq, C90, H2O2, M40t90, C30, M0t90, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0569" /TUlongSig="NA" /TUlongPSig="NA" /label="S99" CDS 267615..268343 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16698798, 19049517, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16698798, 19049517, 27984091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388146.2" /db_xref="EnsemblGenomes-Gn:BSU02640" /db_xref="EnsemblGenomes-Tr:CAB12058" /db_xref="GOA:P42252" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG11175" /db_xref="UniProtKB/Swiss-Prot:P42252" /translation="MDKKETHLIGHLEELRRRIIVTLAAFFLFLITAFLFVQDIYDWL IRDLDGKLAVLGPSEILWVYMMLSGICAIAASIPVAAYQLWRFVAPALTKTERKVTLM YIPGLFALFLAGISFGYFVLFPIVLSFLTHLSSGHFETMFTADRYFRFMVNLSLPFGF LFEMPLVVMFLTRLGILNPYRLAKARKLSYFLLIVVSILITPPDFISDFLVMIPLLVL FEVSVTLSAFVYKKRMREETAAAA*" /label="tatCD CDS" gene 267615..268343 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /label="tatCD gene" downshifts complement(267623) /Source="Nicolas_upshifts" /id="D106" /incds=0 /nref=4 /ntot=146 /MaxReadThrough="1.2763" /MaxDrop="3.13944" /score="-9.00478071" /energy="-8.5" /TU="NA" /idTUdmin="U190" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(268340..268987) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /EC_number="3.4.19.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1362573, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1362573, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrrolidone-carboxylate (pyroglutamate) peptidase" /protein_id="NP_388147.1" /db_xref="EnsemblGenomes-Gn:BSU02650" /db_xref="EnsemblGenomes-Tr:CAB12059" /db_xref="GOA:P28618" /db_xref="InterPro:IPR000816" /db_xref="InterPro:IPR016125" /db_xref="InterPro:IPR029762" /db_xref="InterPro:IPR033693" /db_xref="InterPro:IPR033694" /db_xref="InterPro:IPR036440" /db_xref="SubtiList:BG10873" /db_xref="UniProtKB/Swiss-Prot:P28618" /translation="MRKKVLITGFDPFDKETVNPSWEAAKRLNGFETEEAIITAEQIP TVFRSALDTLRQAIQKHQPDIVICVGQAGGRMQITPERVAINLADARIPDNEGHQPID EEISPDGPAAYWTRLPVKRMTAKMKEHGIPAAVSYTAGTFVCNYLFYGLMDHISRTSP HIRGGFIHIPYIPQQTIDKTAPSLSLDTIVRALRIAAVTAAQYDEDVKSPGGTLH*" /label="pcp CDS" gene complement(268340..268987) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /label="pcp gene" promotor_-10 complement(269002..269021) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 269015..269021 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(269016) /Source="Nicolas_upshifts" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(269036..269040) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 269036..269055 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 269038 /Source="Nicolas_upshifts" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="upshifts" CDS 269066..270178 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase (PLP-dependent)" /protein_id="NP_388148.2" /db_xref="EnsemblGenomes-Gn:BSU02660" /db_xref="EnsemblGenomes-Tr:CAB12060" /db_xref="GOA:P42253" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG11176" /db_xref="UniProtKB/Swiss-Prot:P42253" /translation="MEHLPEQYRQLFPTLQTHTMLASCSQSALAEPVSRAIQDYYDSL LYKGTNWKEAIEKTEFARNEFAKLIGAEPDEVAIVPSVSDALVSVASSLTAFGKKHVV YTDMDFPAVPHVWQAHSDYTVSVIPSIDGVLPLEQYETHISDETVLTCVPHVHYRDGY VQDIKAIAEISQRKGSLLFVDAYQSAGHIPIDVKEWGVDMLAAGTRKYLLGIPGVAFL YVRKELADALKPKASAWFGRESGFDGAYAKVARRFQTGTPAFISVYAAAAALSLLNHI GVSHIRDHVKTICADAVQYAAEKGLQLAAAQGGIQPGMVAIRDERASETAGLLKKKKV ICAPRENVIRLAPHFYNTKEEMRHAIDEIAAKTIHK*" /label="ycbU CDS" gene 269066..270178 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /label="ycbU gene" upshifts complement(269412) /Source="Nicolas_upshifts" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(269415..269434) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(269450..269454) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 270172 /Source="Nicolas_upshifts" /id="D107" /incds=0 /nref=45 /ntot=226 /MaxReadThrough="1.10091" /MaxDrop="4.52742" /score="6.75687898" /energy="-14" /TU="NA" /idTUdmin="U191" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(270220..271659) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 17483215; Product type t: transporter" /codon_start=1 /transl_table=11 /product="flavonoid efflux transporter; drug-export protein" /protein_id="NP_388149.1" /db_xref="EnsemblGenomes-Gn:BSU02670" /db_xref="EnsemblGenomes-Tr:CAB12061" /db_xref="GOA:O35018" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12613" /db_xref="UniProtKB/Swiss-Prot:O35018" /translation="MILETTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLM KELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALA PSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTF SGLVLEHLNWHWIFWISLPFLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGI VFGFSNAGEGSGGWSSPTVIVSLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILG VIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKY GPKWLVIPGFVIVTVVLWFFSNVTTTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQL PREFYPDGTAIMNTLQQMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQALTAG VQHAFVFAMIVAIIGLIGAFFMKRVKVDH*" /label="lmrB CDS" gene complement(270220..271659) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /label="lmrB gene" downshifts complement(270227) /Source="Nicolas_upshifts" /id="D108" /incds=0 /nref=162 /ntot=245 /MaxReadThrough="0.65833" /MaxDrop="6.75228" /score="18.3484535" /energy="-14" /TU="U193" /idTUdmin="U193" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(271699..272265) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12718394, 15317768, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12718394, 15317768, 17483215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of lmrAB and yxaGH operons (flavonoid and antibiotic resistance)" /protein_id="NP_388150.1" /db_xref="EnsemblGenomes-Gn:BSU02680" /db_xref="EnsemblGenomes-Tr:CAB12062" /db_xref="GOA:O34619" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12612" /db_xref="UniProtKB/Swiss-Prot:O34619" /translation="MSYGDSREKILSAATRLFQLQGYYGTGLNQIIKESGAPKGSLYY HFPGGKEQLAIEAVNEMKEYIRQKIADCMEACTDPAEGIQAFLKELSCQFSCTEDIEG LPVGLLAAETSLKSEPLREACHEAYKEWASVYEEKLRQTGCSESRAKEASTVVNAMIE GGILLSLTAKNSTPLLHISSCIPDLLKR*" /label="lmrA CDS" gene complement(271699..272265) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /label="lmrA gene" promotor_-10 complement(272303..272322) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(272317) /Source="Nicolas_upshifts" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(272337..272344) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 272419..272425 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 272441..272458 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 272447 /Source="Nicolas_upshifts" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="upshifts" CDS 272482..273609 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /EC_number="3.5.1.1" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914346, 17686772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346, 17686772; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-asparaginase 2 (putative lipoprotein)" /protein_id="NP_388151.1" /db_xref="EnsemblGenomes-Gn:BSU02690" /db_xref="EnsemblGenomes-Tr:CAB12063" /db_xref="GOA:O34482" /db_xref="InterPro:IPR004550" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG12755" /db_xref="UniProtKB/Swiss-Prot:O34482" /translation="MKKQRMLVLFTALLFVFTGCSHSPETKESPKEKAQTQKVSSASA SEKKDLPNIRILATGGTIAGADQSKTSTTEYKAGVVGVESLIEAVPEMKDIANVSGEQ IVNVGSTNIDNKILLKLAKRINHLLASDDVDGIVVTHGTDTLEETAYFLNLTVKSDKP VVIVGSMRPSTAISADGPSNLYNAVKVAGAPEAKGKGTLVVLNDRIASARYVTKTNTT TTDTFKSEEMGFVGTIADDIYFNNEITRKHTKDTDFSVSNLDELPQVDIIYGYQNDGS YLFDAAVKAGAKGIVFAGSGNGSLSDAAEKGADSAVKKGVTVVRSTRTGNGVVTPNQD YAEKDLLASNSLNPQKARMLLMLALTKTNDPQKIQAYFNEY*" /label="ansZ CDS" gene 272482..273609 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /label="ansZ gene" downshifts 273582 /Source="Nicolas_upshifts" /id="D109" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="1.70459" /MaxDrop="4.27333" /score="23.2201078" /energy="-7.6" /TU="NA" /idTUdmin="U194" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 273706..273712 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 273726..273745 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 273726 /Source="Nicolas_upshifts" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 273772..274410 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8396026, 15812018, 18053819, 11029590, 24827611, 28963005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8396026, 15812018, 18053819, 11029590, 24827611, 28963005; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="secreted alkaliphilic lipase" /protein_id="NP_388152.1" /db_xref="EnsemblGenomes-Gn:BSU02700" /db_xref="EnsemblGenomes-Tr:CAB12064" /db_xref="GOA:P37957" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="PDB:1I6W" /db_xref="PDB:1ISP" /db_xref="PDB:1R4Z" /db_xref="PDB:1R50" /db_xref="PDB:1T2N" /db_xref="PDB:1T4M" /db_xref="PDB:2QXT" /db_xref="PDB:2QXU" /db_xref="PDB:3D2A" /db_xref="PDB:3D2B" /db_xref="PDB:3D2C" /db_xref="PDB:3QMM" /db_xref="PDB:3QZU" /db_xref="PDB:5CRI" /db_xref="PDB:5CT4" /db_xref="PDB:5CT5" /db_xref="PDB:5CT6" /db_xref="PDB:5CT8" /db_xref="PDB:5CT9" /db_xref="PDB:5CTA" /db_xref="PDB:5CUR" /db_xref="SubtiList:BG10679" /db_xref="UniProtKB/Swiss-Prot:P37957" /translation="MKFVKRRIIALVTILMLSVTSLFALQPSAKAAEHNPVVMVHGIG GASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGAKKV DIVAHSMGGANTLYYIKNLDGGNKVANVVTLGGANRLTTGKALPGTDPNQKILYTSIY SSADMIVMNYLSRLDGARNVQIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN*" /label="estA CDS" gene 273772..274410 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /label="estA gene" downshifts 274396 /Source="Nicolas_upshifts" /id="D110" /incds=0 /nref=15 /ntot=117 /MaxReadThrough="4.54554" /MaxDrop="4.10395" /score="23.2201078" /energy="-7.6" /TU="U195" /idTUdmin="U194" /TUdmin=814 /isTUend="FALSE" /label="downshifts" S_feature 274441..275031 /Source="Nicolas_S_feature" /locus_tag="new_292874_293464" /HighExp="M9-tran, GM 150, LoTm, MG 150, GM 120, aero, T-1.40H, M/G, S2, GM 90" /AntisenseName="yczC" /AntisenseCor="3.5651747957185502E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S100" CDS complement(274448..274831) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_388153.1" /db_xref="EnsemblGenomes-Gn:BSU02710" /db_xref="EnsemblGenomes-Tr:CAB12065" /db_xref="GOA:O31469" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG12778" /db_xref="UniProtKB/Swiss-Prot:O31469" /translation="MELAGFMLRACALLLDVIIAAAVILAAGFTFGDGSAGVIIVAIL MLIVYPLLMPLTNWKGTLGKKIIGLQIVRDETYKKISFPQAIVRYLIAWVHVFSRLIY LTAAFTKKKQTVHDMAAKTIVLKAE*" /label="yczC CDS" gene complement(274448..274831) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /label="yczC gene" downshifts complement(274472) /Source="Nicolas_upshifts" /id="D111" /incds=0 /nref=4 /ntot=94 /MaxReadThrough="0.85389" /MaxDrop="2.7858" /score="15.0330092" /energy="-12.1" /TU="NA" /idTUdmin="U196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" Polymorphism join(274645,274647) /Source="geneious" /ID="SNP_BsDelta6_293079_293079" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=186 /Change="C -> T" /Codon_Change="CTG -> CTA" /Coverage=154 /locus_tag="BSU_02710" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" promotor_-10 complement(274861..274880) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(274868) /Source="Nicolas_upshifts" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(274894..274901) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 275003..275006 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 275022..275041 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 275033 /Source="Nicolas_upshifts" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 275066..276142 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388154.1" /db_xref="EnsemblGenomes-Gn:BSU02720" /db_xref="EnsemblGenomes-Tr:CAB12066" /db_xref="GOA:O34478" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR007889" /db_xref="InterPro:IPR036915" /db_xref="SubtiList:BG12756" /db_xref="UniProtKB/Swiss-Prot:O34478" /translation="MGKVKRNAPCPCGSGKKYKKCCGSKVVDFPAELAAKEAKQIQED LVEYAFTVHRESISGFINQHDFLSAMDRQTKDISVFNLGIWGIFFHPLAGEKTIFEEY LQKKGDSITRPKTREIVESWQSMTPALLLLKDLKEGIIHFEDVITAKQFEVEMDASNQ DLPPVGSLILGYPIHEAEKAEFFMQFTIFPVKRTEALISKVKKYADAAVKDGKTPEDF MKQEFNNVLFALLAEKDEEPQAEKAEVSTVEWANDLEKETAAAIEEGMSGEEYPTELI PAVIDIWKTFCEKKSPVIRKPEAFAAAVEYYVNAISLNGASVSQAKLAKKYGVSASTI SSRYKEIESTLQDEADRFAQALSS*" /label="yccF CDS" gene 275066..276142 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /label="yccF gene" downshifts 276136 /Source="Nicolas_upshifts" /id="D112" /incds=0 /nref=60 /ntot=248 /MaxReadThrough="1.55048" /MaxDrop="5.18328" /score="33.0000484" /energy="-12.9" /TU="NA" /idTUdmin="U197" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(276182..277138) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [NatR]" /protein_id="NP_388155.1" /db_xref="EnsemblGenomes-Gn:BSU02730" /db_xref="EnsemblGenomes-Tr:CAB12067" /db_xref="GOA:P70954" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR032834" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11997" /db_xref="UniProtKB/Swiss-Prot:P70954" /translation="MITLFQCLYLILFSFICYQGAAAFSHSTAASWLAAALGAAAAGL YIWNTKRVWKHCSSGLCAWIAVIQVMSVGVVLIGTDIMPVLCVIAIFAGCEGLRIGQS ALQARLSDQIDKLTQAEQHANQMLIDVRSRNHDTMKHITAIKSAQPKADTQAYIQNWA DQYSQYDRFLKGENAYVAGVLYDFLEKARASNVSVSLHMHTPLSSLPFSPADQVSLVG NILENALDSAAEAREKAEIKLETSLRSGLYVLTCENSTPGMDPKVLDTIYQSFGRSTK NGAHEGMGTYIIQKLVKGAFGRLDFTYRHPIFRLEIKIPFQK*" /label="natK CDS" gene complement(276182..277138) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /label="natK gene" downshifts complement(276210) /Source="Nicolas_upshifts" /id="D113" /incds=0 /nref=1 /ntot=129 /MaxReadThrough="0.86926" /MaxDrop="2.67125" /score="14.02819" /energy="-12.9" /TU="NA" /idTUdmin="U198" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(277151..277852) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [NatK]" /protein_id="NP_388156.1" /db_xref="EnsemblGenomes-Gn:BSU02740" /db_xref="EnsemblGenomes-Tr:CAB12068" /db_xref="GOA:P70955" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11998" /db_xref="UniProtKB/Swiss-Prot:P70955" /translation="MVKVGLVDDYRVDLEKLEAIVSRMQDVEIVFSTDSAKEAYRRVK NGDIDLLLADIEMPHMSGYELADLIKSHSLDVDVIFVTGHGGYAVHAFDLNVHDYIMK PYYADRLAASFDRYLKKKTETSLNGRILIKQKSEMHVLQKKDIIFAERTGRSTTIVTT AEEVQTYQTLNDIKGDLPEKDFLRSHRSFIINIHYIKHFSAYTKHSFTVSFEGTSKKA MITKQQLDYFQNYYF*" /label="natR CDS" gene complement(277151..277852) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /label="natR gene" promotor_-10 complement(277876..277895) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(277882) /Source="Nicolas_upshifts" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(277911..277914) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 277932..277935 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 277951..277970 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 277961 /Source="Nicolas_upshifts" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 277996..278736 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10356997, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388157.1" /db_xref="EnsemblGenomes-Gn:BSU02750" /db_xref="EnsemblGenomes-Tr:CAB12069" /db_xref="GOA:P46903" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11338" /db_xref="UniProtKB/Swiss-Prot:P46903" /translation="MITLTDCSRRFQDKKKVVKAVRDVSLTIEKGEVVGILGENGAGK TTMLRMIASLLEPSQGVITVDGFDTVKQPAEVKQRIGVLFGGETGLYDRMTAKENLQY FGRLYGLNRHEIKARIEDLSKRFGMRDYMNRRVGGFSKGMRQKVAIARALIHDPDIIL FDEPTTGLDITSSNIFREFIQQLKREQKTILFSSHIMEEVQALCDSVIMIHSGEVIYR GALESLYESERSEDLNYIFMSKLVRGIS*" /label="natA CDS" gene 277996..278736 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /label="natA gene" CDS 278737..279897 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10356997, 15849754, 16850406, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 15849754, 16850406, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (permease)" /protein_id="NP_388158.1" /db_xref="EnsemblGenomes-Gn:BSU02760" /db_xref="EnsemblGenomes-Tr:CAB12070" /db_xref="GOA:P46904" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11339" /db_xref="UniProtKB/Swiss-Prot:P46904" /translation="MLSHIYKKEMIDALRDRKTILLTILVPMIMMLGLVFFYESMLSD KGEQYTLAVGHSLPPALESKLNEIDEISVKTFAKPEEAVDEGKADAYLNVPKEFDSYV NSMTPFKVDVYGNSIDQGSSNAMQLVQSALDQYKNEIVQQRLTNKHIDQSVIQPFTIQ QKEADEEKGTSAIMLSAILPMLILTSIVSGAMPIALDIMAGEKDRKSIEALLLTPVSR NKVLVGKWLAVSTFGVASGVFALVFLILSTVLFTENLKTAFQLGDHMWSVIGASALII VLSALLISAMELFISIMSSSVKEAQSYMSLVVFLPVFPMFFIFSKAPNQFDLSYFLIP FLNLHALFKQLLFGMVDPATILSTSGTIAVLIAIFFLLARACFLKDKWVLPK*" /label="natB CDS" gene 278737..279897 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /label="natB gene" promotor_-35 279948..279956 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 279968..279986 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 279968 /Source="Nicolas_upshifts" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 280033..280965 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /EC_number="1.-.-.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322186, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ion channel associated aldo-keto reductase" /protein_id="NP_388159.1" /db_xref="EnsemblGenomes-Gn:BSU02770" /db_xref="EnsemblGenomes-Tr:CAB12071" /db_xref="GOA:P46905" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11340" /db_xref="UniProtKB/Swiss-Prot:P46905" /translation="MDQTRTLGKTKLKVKRIGFGANAVGGHNLFPNLNDETGKDLVRT ALDGGVNFIDTAFIYGLGRSEELIGEVVQERGVRNELIIATKGAHKEVDGSIELDNSR EFLRSEVEKSLKRLKTDYIDLYYVHFPDGKTPLAEVAGTLKELKDEGKIKAIGASNLD YQQLQDFNADGYLEVFQAEYSLIQRDAEKELLPYCEKQGISFIPYFPLASGLLTGKFT QDTVFDDFRKDKPQFQGETFIHNLKKVDKLKAVAEEKQADTAHVALAWLLTRPAIDAI IPGAKRPEQLQDNLKTLNIELTEDEVNFISDIFK*" /label="yccK CDS" gene 280033..280965 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /label="yccK gene" CDS complement(281005..282069) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 22496484; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in swarming behaviour" /protein_id="NP_388160.1" /db_xref="EnsemblGenomes-Gn:BSU02780" /db_xref="EnsemblGenomes-Tr:CAB12072" /db_xref="GOA:O34538" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="InterPro:IPR031343" /db_xref="PDB:4R4G" /db_xref="SubtiList:BG12757" /db_xref="UniProtKB/Swiss-Prot:O34538" /translation="MFQKKTYAVFLILLLMMFTAACSGSKTSAEKKESETEKSSDIAQ VKIKDVSYTLPSKYDKSTSDDQLVLKVNVAVKNTGKDPLNVDSMDFTLYQGDTKMSDT DPEDYSEKLQGSTINADKSVEGNLFFVVDKGKQYELNYTPESYGDKKPKSVTFKIDGK DKKILATADKLQDSAKALSAYVDVLLFGKDNADFEKITGANKNEIVNDFNESAKDGYL SASGLSSTYADSKALDNIVNGIKEGLSKNSSIQAKTTSISKDEAIVEATVKPVDASSL SDRIEDKVKDYYSKNSSASYEEAVKYALQVYPEEFKKLGPASSEKTVEVKMKKNDIDQ WQLDMDDYRAAELVEAFIKE*" /label="ycdA CDS" gene complement(281005..282069) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /label="ycdA gene" downshifts complement(281006) /Source="Nicolas_upshifts" /id="D114" /incds=0 /nref=198 /ntot=222 /MaxReadThrough="0.57029" /MaxDrop="8.85093" /score="27.0612397" /energy="-13.7" /TU="NA" /idTUdmin="U201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(282070..282260) /Source="Nicolas_S_feature" /locus_tag="new_300503_300693_c" /HighExp="S5, S4, MG 45, MG 15, MG-0.2, MG 25, MG-0.1, MG 10, S3, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S101" CDS complement(282092..282223) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513941.1" /translation="MTKEGGVSRKSGENREKRTDFFGYMMLIHSKRSISQRQKTPLS* " /label="hypothetical protein CDS" gene complement(282092..282223) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /label="gene" promotor_-10 complement(282245..282264) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(282265) /Source="Nicolas_upshifts" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(282279..282286) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 282397..283815 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388161.1" /db_xref="EnsemblGenomes-Gn:BSU02790" /db_xref="EnsemblGenomes-Tr:CAB12073" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12758" /db_xref="UniProtKB/Swiss-Prot:O34621" /translation="MKGAAFVKKEGLKQKALEIGRVPTHLKLEIEDYGGDDKRAHFCW ADPQDENTGIIVELGPDGELESLSRDIEPESGERLSEEKLEDIMRQFVETHHPGALSA FVREENDRAYGDKVRFSYVQMEAGLPLPMSGFMADVSLSGEIVYFRYYGEAGSIIKPK RVADVEEALAFIKKDVEFDLLFEVLHRSVYKNGDDQPHLVYEPEGRAITVPADLVQEE QAVDDDDDYREPESFPLPLFEGIREKADPDSMIGIENGFVKEREADLGDGRIGIVWRN PDDPVYQPADKSMDSWFKGRTHQVLKTIYNKETGKLEGVMSFMEKKGPLTVTLAECEK IALRFLFALFPNADQYFRIRYDEKDEEENAVAGFTFEAHCHGVPLRFGQIRICVSRQT GYITVYMGPDIDPNKLATIDPVPAISVEQAKSIFWQHFKVELGWEREYGDDEEHSYRL VYKPVYPHFIDAHTGEPVFSIW*" /label="ycdB CDS" gene 282397..283815 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /label="ycdB gene" promotor_-10 complement(283858..283876) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(283866) /Source="Nicolas_upshifts" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(283890..283897) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 283922..284001 /Source="Nicolas_S_feature" /locus_tag="new_302355_302434" /HighExp="ferm, M40t45, M0t45, Lbstat, S0, nit, LBGtran, Lbtran, G135, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S102" upshifts 283922 /Source="Nicolas_upshifts" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="upshifts" promotor_-35 283924..283930 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-35" promotor_-10 283945..283962 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-10" CDS 284002..285363 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388162.1" /db_xref="EnsemblGenomes-Gn:BSU02800" /db_xref="EnsemblGenomes-Tr:CAB12074" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12759" /db_xref="UniProtKB/Swiss-Prot:O34772" /translation="MVNKQLKKKAQEIGNVPTHYELEIEDYDQKQKKYGQAYFIWKDP KDPEKHITVELRNDGALLTFSTTVHSETDKKLPDAELKLTALQFAAANHPGTFMNFHF QGKEERGQHIRFVYTKMELGLPIPNSGFLIDMTRSGQIVHFLYYGEGHKAEVPTEFVA KEKVVSHYLNTMSFELMYDVIDGEQEPRLVYEPILPGYSYPADVDEIVPDQHIADERI ENTAPLPPLQNKEEVDIFALLGFTSDMQKVSERDFGEQIGSTWRRGAAPERKDLSIGS YFETRNKNTIKMKTDKRTGKLKAALSFMDWRNNLQCSTEECQEIALQFLYALYPRAAE FFRVNPVRIDERGRVRNHFSVWYKGVPLRFGAARIIVNPETGLIDAFMAPDIEPEQLE AINHRPDVSAEEAKEAFLAAFDVKLEWQPDFTAGSDQHCKLVYKPVYPSYIDAHIRKK KRL*" /label="ycdC CDS" gene 284002..285363 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /label="ycdC gene" S_feature 285364..285944 /Source="Nicolas_S_feature" /locus_tag="new_303797_304377" /HighExp="ferm, M0t45, G135, G180, H2O2, M40t45, G150, Paraq, S0, nit" /AntisenseName="cwlK" /AntisenseCor="0.27553388443794402" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S103" CDS complement(285371..285874) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17588176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17588176; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="murein L,D:-endopeptidase" /protein_id="NP_388163.1" /db_xref="EnsemblGenomes-Gn:BSU02810" /db_xref="EnsemblGenomes-Tr:CAB12075" /db_xref="GOA:O34360" /db_xref="InterPro:IPR009045" /db_xref="SubtiList:BG12760" /db_xref="UniProtKB/Swiss-Prot:O34360" /translation="MNLPAKTFVILCILFLLDLCFSYIRHEWHSQNALQDMPVPSDLH PIVKQNADALKAAAANKGIDVVITEGFRSFKEQDELYKQGRTKKGNIVTYARGGESYH NYGLAIDFALQKKDGSIIWDMEYDGNQNGKSDWLEVVEIAKTLGFEWGGDWKRFKDYP HLEMIPN*" /label="cwlK CDS" gene complement(285371..285874) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /label="cwlK gene" S_feature complement(285875..285956) /Source="Nicolas_S_feature" /locus_tag="new_304308_304389_c" /HighExp="Cold, T0.30H, LBGstat, C30, T-0.40H, T1.0H, T1.30H, H2O2, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S104" upshifts 285946 /Source="Nicolas_upshifts" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="upshifts" promotor_-10 complement(285948..285967) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 285949..285968 /Source="Nicolas_upshift_promotors" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(285957) /Source="Nicolas_upshifts" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="upshifts" CDS 285997..287118 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388164.1" /db_xref="EnsemblGenomes-Gn:BSU02820" /db_xref="EnsemblGenomes-Tr:CAB12076" /db_xref="GOA:O34327" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4GYO" /db_xref="SubtiList:BG12663" /db_xref="UniProtKB/Swiss-Prot:O34327" /translation="MRAKIPSEEVAVKLNEWYKLIRAFEADQAEALKQEIEYDLEDME ENQDLLLYFSLMEFRHRIMLDKLMPVKDSDTKPPFSDMLNEIESNQQKLTGLLEYYFY YFRGMYEFKQKNFILAIDHYKHAEEKLEYVEDEIEKAEFLFKVAEVYYHIKQTYFSMN YASQALDIYTKYELYGRRRVQCEFIIAGNLTDVYHHEKALTHLCSALEHARQLEEAYM IAAAYYNVGHCKYSLGDYKEAEGYFKTAAAIFEEHNFQQAVQAVFSLTHIYCKEGKYD KAVEAYDRGIKSAAEWEDDMYLTKFRLIHELYLGSGDLNVLTECFDLLESRQLLADAE DLLHDTAERFNQLEHYESAAFFYRRLMNIKKKLAEQRFQ*" /label="rapJ CDS" gene 285997..287118 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /label="rapJ gene" downshifts 287112 /Source="Nicolas_upshifts" /id="D115" /incds=0 /nref=88 /ntot=228 /MaxReadThrough="3.8438" /MaxDrop="5.06867" /score="32.2653577" /energy="-13.2" /TU="U204" /idTUdmin="U204" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 287159..287165 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 287180..287198 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 287183 /Source="Nicolas_upshifts" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 287225..288001 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388165.1" /db_xref="EnsemblGenomes-Gn:BSU02830" /db_xref="EnsemblGenomes-Tr:CAB12077" /db_xref="GOA:P80869" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12761" /db_xref="UniProtKB/Swiss-Prot:P80869" /translation="MYKDLTGKTAIVTGSSKGIGKAIAERFGKEKMNVVVNYHSDPSG ADETLEIIKQNGGKAVSVEADVSKEEGIQALLDTALEHFGTLDVMVNNSGFNGVEAMP HEMSLEDWQRVIDVNVTGTFLGAKAALNHMMKNNIKGNVLNISSVHQQIPRPVNVQYS TSKGGIKMMTETLALNYADKGIRVNAIAPGTIATESNVDTKKEESRQKQLKKIPMKAF GKPEEVAAAAAWLVSEEASYVTGATLFVDGGMTLYPSQLE*" /label="ycdF CDS" gene 287225..288001 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /label="ycdF gene" downshifts complement(287232) /Source="Nicolas_upshifts" /id="D116" /incds=0 /nref=10 /ntot=23 /MaxReadThrough="0.31912" /MaxDrop="4.8095" /score="0.506500496" /energy="-5.8" /TU="NA" /idTUdmin="U205" /TUdmin="-1914" /isTUend="FALSE" /label="downshifts" CDS 288026..289711 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-carbohydrate hydrolase" /protein_id="NP_388166.1" /db_xref="EnsemblGenomes-Gn:BSU02840" /db_xref="EnsemblGenomes-Tr:CAB12078" /db_xref="GOA:O34364" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12762" /db_xref="UniProtKB/Swiss-Prot:O34364" /translation="MKTDWWKDAVVYQIYPRSFQDSNGDGIGDLRGIISRLDYIKELG ADVIWICPIYPSPNVDYGYDVTNHKAIMDSYGTMDDFHELLDQVHQRGLKLVMDFVLN HTSVEHPWFKEAELDKNSKYRSYYYWRPGTKNGPPTDWLSNYGCPVWQYEEHTGEYYL HMNAVKQADLNWENPEVRQAVYDMMKFWLDKGVDGLRIDQLHLISKKEYLPSYEDYIN QQAEPKPFQPNGERIHDYLKEITDEVFSHYDVMSVGEVGSVTPEEGLKYTGTDKHELN MIFHFQHMELDQQPGKEHWDLKPLELSDLKSVLTKWQKKLEHQGWNTLFWCNHDQPRI VSRFGDDGEYRKASAKMLAAVIYFMKGTPYIYQGEEIGMTNAPFTRIEDYKDIQTINM YHKRVFEKGYDPNDVMRSILAKSRDHARTPMQWNSGKNAGFTDGTPWLKVNPNFTAIN VEEAQGDPDSVLNYYKKLISLRKQYADLMKGSFDLLLPDDPQLFVYMRENSKQQLLSV NNFSKEQAVFQWPKNCGKAQASLLLSNYNNDDLDDEMVFRPYESRVYLLDKTN*" /label="ycdG CDS" gene 288026..289711 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /label="ycdG gene" promotor_no_box 288966..289066 /Source="Nicolas_upshift_promotors" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 289026 /Source="Nicolas_upshifts" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 289092 /Source="Nicolas_upshifts" /id="D117" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.77365" /MaxDrop="2.18547" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=1914 /isTUend="FALSE" /label="downshifts" downshifts 289708 /Source="Nicolas_upshifts" /id="D118" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="5.8252" /MaxDrop="5.18702" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" promotor_-35 289802..289809 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 289825..289844 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 289831 /Source="Nicolas_upshifts" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 289899..290858 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9379902, 12426338, 14730579, 21813502; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="Zn(II)-binding lipoprotein" /protein_id="NP_388167.1" /db_xref="EnsemblGenomes-Gn:BSU02850" /db_xref="EnsemblGenomes-Tr:CAB12079" /db_xref="GOA:O34966" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="PDB:2O1E" /db_xref="SubtiList:BG12763" /db_xref="UniProtKB/Swiss-Prot:O34966" /translation="MFKKWSGLFVIAACFLLVAACGNSSTKGSADSKGDKLHVVTTFY PMYEFTKQIVKDKGDVDLLIPSSVEPHDWEPTPKDIANIQDADLFVYNSEYMETWVPS AEKSMGQGHAVFVNASKGIDLMEGSEEEHEEHDHGEHEHSHAMDPHVWLSPVLAQKEV KNITAQIVKQDPDNKEYYEKNSKEYIAKLQDLDKLYRTTAKKAEKKEFITQHTAFGYL AKEYGLKQVPIAGLSPDQEPSAASLAKLKTYAKEHNVKVIYFEEIASSKVADTLASEI GAKTEVLNTLEGLSKEEQDKGLGYIDIMKQNLDALKDSLLVKS*" /label="znuA CDS" gene 289899..290858 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /label="znuA gene" promotor_-35 290454..290460 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 290474..290493 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 290478 /Source="Nicolas_upshifts" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" downshifts 290830 /Source="Nicolas_upshifts" /id="D119" /incds=0 /nref=140 /ntot=250 /MaxReadThrough="6.07181" /MaxDrop="5.15011" /score="8.99106569" /energy="-15.9" /TU="U206,U208,U209" /idTUdmin="U206" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS 290914..291609 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Zn(II) transporter (ATP-binding protein)" /protein_id="NP_388168.1" /db_xref="EnsemblGenomes-Gn:BSU02860" /db_xref="EnsemblGenomes-Tr:CAB12080" /db_xref="GOA:O34946" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12764" /db_xref="UniProtKB/Swiss-Prot:O34946" /translation="MNLVSLKDIVFGYSHTPVLDKVSLDIESGEFVGITGPNGASKST LIKVMLGMLKPWEGTVTISKRNTEGKRLTIGYVPQQISSFNAGFPSTVLELVQSGRYT KGKWFKRLNEEDHLEVEKALKMVEMWDLRHRKIGDLSGGQKQKICIARMLASNPDLLM LDEPTTAVDYDSRKGFYEFMHHLVKNHNRTVVMVTHEQNEVQQFLDKVIRLERGEKGG WKCLTWNSCDELF*" /label="znuC CDS" gene 290914..291609 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /label="znuC gene" CDS 291567..292409 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity Zn(II) ABC transporter (permease)" /protein_id="NP_388169.1" /db_xref="EnsemblGenomes-Gn:BSU02870" /db_xref="EnsemblGenomes-Tr:CAB12081" /db_xref="GOA:O34610" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12765" /db_xref="UniProtKB/Swiss-Prot:O34610" /translation="MEMFDLEFMRRAFLAGGMIAVMAPILGVYLVLRRQALMADTLSH ISLSGVAIGFFLSTNITAASIVVVTIGAIGIEYMRRAYRTYSEVSIAILMAAGLSFAM FLISLSKGTANMSIDQYLFGSLVTVNQQQVYIISIITLLILLYFIVLRRPLYLLTFDE ATAKTSGINTNVLSLSFSIVTGLAISVIIPIIGVLLVSALLVLPAAFAIRIAKGFNMV FITAILISLFSVFTGLTSSYQLGTPPGPSITLLLIVLLLIGFAVQGVWTFIKKEAQRK KRSR*" /label="znuB CDS" gene 291567..292409 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /label="znuB gene" downshifts 292396 /Source="Nicolas_upshifts" /id="D120" /incds=0 /nref=168 /ntot=266 /MaxReadThrough="2.4865" /MaxDrop="6.44929" /score="27.8218406" /energy="-13.6" /TU="NA" /idTUdmin="U206" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(292447..293442) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16428414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative luciferase-like monooxygenase" /protein_id="NP_388170.2" /db_xref="EnsemblGenomes-Gn:BSU02880" /db_xref="EnsemblGenomes-Tr:CAB12082" /db_xref="GOA:O34504" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12766" /db_xref="UniProtKB/Swiss-Prot:O34504" /translation="MIHLSILDQAPVSKGESPVTTLQHSVELAQLSEQWGYKRYWFAE HHSTKGLASTAPEIMIARIAAQTNTIRVGSGGVLLPQYSPFKVAETFRQLEALYPNRI DLGVGRSPGGTTKTRLALTDGVKKSLTEFNRQLQDVSYFLTDSLPPDHPYAGIKAAPL IGTAPELWVLGLGENSARRAAHQGIGYVFGHFINPERGENAFRIYRESFRPSAHFSNP SALFTIFVICAKTDEEAEELALSQDLWLLRVGKGLDSRVPSIEEAKAHPYTASDKKLI EENRKRMVIGSPTTVKQQLLDLTGCYETNEIMVLCNVFDFEAKKESYERLAELFL*" /label="yceB CDS" gene complement(292447..293442) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /label="yceB gene" promotor_-35 293398..293405 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-35" promotor_-10 293420..293439 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-10" S_feature 293426..293628 /Source="Nicolas_S_feature" /locus_tag="new_311859_312061" /HighExp="Diami, Etha, dia5, Salt, H2O2, dia15, Paraq, T-0.40H, T0.30H, G135" /AntisenseName="yceB" /AntisenseCor="0.84300534435872998" /AntisenseRegPval="-73.099999999999994" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S105" upshifts 293426 /Source="Nicolas_upshifts" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="upshifts" promotor_-10 complement(293474..293493) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(293482) /Source="Nicolas_upshifts" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(293508..293515) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 293612..293621 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 293630..293725 /Source="Nicolas_S_feature" /locus_tag="new_312063_312158" /HighExp="T0.0H, T-0.40H, T-1.10H, T0.30H, Salt, T1.0H, Etha, T-1.40H, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S106" upshifts 293630 /Source="Nicolas_upshifts" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 293634..293649 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 293726..294325 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388171.1" /db_xref="EnsemblGenomes-Gn:BSU02890" /db_xref="EnsemblGenomes-Tr:CAB12083" /db_xref="GOA:P81100" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12767" /db_xref="UniProtKB/Swiss-Prot:P81100" /translation="MAISLEKGQRIDLTKGKAGLSKLMVGLGWDPVSSGGGFFSKLLG GGGPNIDCDASVLMLENGKFTDKKNLIYFGNLKSRCGGVQHTGDNLTGDGAGDDEQIM IDLDKVPGNIDKLVFVVNIYDCVRRKQDFGMIQNAFIRVVDQSNHEEMLKYNLRDNYA GRTSLITAEIYRSGSEWKFAAVGEGTNDTRLEDIISRYV*" /label="yceC CDS" gene 293726..294325 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /label="yceC gene" CDS 294347..294928 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388172.1" /db_xref="EnsemblGenomes-Gn:BSU02900" /db_xref="EnsemblGenomes-Tr:CAB12084" /db_xref="GOA:P80875" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12768" /db_xref="UniProtKB/Swiss-Prot:P80875" /translation="MTISLAKGQKVDLTKTNPGLSKVVVGLGWDTNKYDGGHDFDLDS SVFLLDAAGKCASPNDFIFYNQLEGGNGSVVHSGDNLTGAGEGDDENVKVNLSAVPAN IDKISFVITIHDAEARSQNFGQVSNAFVRIVNEETNEELIRYDLAEDFSIETAIIAGE LYRHNGEWKFSAIGSGYQGGLARIATDYGLQVG*" /label="yceD CDS" gene 294347..294928 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /label="yceD gene" CDS 294963..295541 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388173.1" /db_xref="EnsemblGenomes-Gn:BSU02910" /db_xref="EnsemblGenomes-Tr:CAB12085" /db_xref="GOA:O34384" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12769" /db_xref="UniProtKB/Swiss-Prot:O34384" /translation="MAIQLSKGQRIDLTKTNPGLTKAVIGLGWDTNKYSGGHDFDLDA SAFLVDAHDNCVNDLDFVFYNNLEHPSGGVIHTGDNRTGEGDGDDEQIIVDFSKIPAH IEKIGITVTIHDAEARSQNFGQVSNAFVRVVDEETQNELLRFDLGEDFSIETAVVVCE LYRHGGEWKFNAIGSGFSGGLAALCRNYGLQV*" /label="yceE CDS" gene 294963..295541 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /label="yceE gene" CDS 295592..296365 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 24366250; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative stress adaptation transporter (tellurite resistance)" /protein_id="NP_388174.1" /db_xref="EnsemblGenomes-Gn:BSU02920" /db_xref="EnsemblGenomes-Tr:CAB12086" /db_xref="GOA:O34447" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="SubtiList:BG12770" /db_xref="UniProtKB/Swiss-Prot:O34447" /translation="MDFLHHILSTYASFFDWKMWGEVLTDPVSWGLIGSLVVLEGLLS ADNALVLAVMVKHLPEKQRKKALTYGLFGAYIFRFIFIGLGMLLIKFWWIKVLGALYL AWLVIKHFWIGEKEEEADGMKKNSWMVRTFGIFWATVISVELMDLAFSVDSILAAFAV SEKVWVLLIGGMLGILMMRTVAKVFLVLIDKIPELENTAFVLIGIIALKMAGSAFHYE MPHSVFFIIIIAAFAVTLIIHYINKQKQVREQTAASKEE*" /label="yceF CDS" gene 295592..296365 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /label="yceF gene" downshifts 296352 /Source="Nicolas_upshifts" /id="D121" /incds=0 /nref=46 /ntot=239 /MaxReadThrough="6.82513" /MaxDrop="4.0674" /score="4.0495978" /energy="-8.2" /TU="U212" /idTUdmin="U210" /TUdmin=2728 /isTUend="FALSE" /label="downshifts" CDS 296450..298063 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxic compound adaptation protein (tellurite resistance)" /protein_id="NP_388175.1" /db_xref="EnsemblGenomes-Gn:BSU02930" /db_xref="EnsemblGenomes-Tr:CAB12087" /db_xref="InterPro:IPR025647" /db_xref="SubtiList:BG12771" /db_xref="UniProtKB/Swiss-Prot:O34809" /translation="MRQEELTIHKALPADGDWKSLLFQPLPERDHYETAQGLSFSRLA GQILGTPIDETDYYNELYELSVNDRITILSETLDKTIEPETFQKLQHIHSINQKEKGL SVSRFVAFLDGEKLIAKHSNPLMHRHLRKALMTLLHTFADSHEKGLNHPDFRRVLLDV SKFSLNHLNPWLEKTDIEREMPKVVWYGDATKSQLYFLYYLMLVGCDVLLFHPAGTDQ LALVDPKQELGFTEKLPDVSELQPFPKEKPDRKSTVAYRSTKEIEHVLNHEESMLYKP WQFRDHTPVSVTLKTTYDELFLITKERAFIRPNFKADKHSIEIPNVFAKIMGVSKDNK EYWNRLHTLADYQETEMVRSFPFTEEIKSNYQFHYSHALDQEGNIDPDKLMASNVWQY KQLPAGVQTAIAKTISRMCRYPRLKALHQEQVKDVQIYLFKQTTNLPANLLKLIQMFD YAQTVPKLVLYHTEMSGGLTRSDAAALLFLNEIGIDIIIYNPPGHQDIEQFIEEDQYD IHWLDDMVFQQDYKEPSLVKRLFRTITQK*" /label="yceG CDS" gene 296450..298063 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /label="yceG gene" CDS 298079..299170 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative reactive oxygen species resistance protein" /protein_id="NP_388176.1" /db_xref="EnsemblGenomes-Gn:BSU02940" /db_xref="EnsemblGenomes-Tr:CAB12088" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG12772" /db_xref="UniProtKB/Swiss-Prot:O34833" /translation="MTTENQNPLVLDKNEEISQQKADDIRLQLRQEPEVKRLAQQIDV KNQMELLEYGKEPAVEISKFSDRILGMMKTTSVTDSGTMLTQLGKIMDRFDKNDFDEP KGLMAKIFKRGGSMIEKIFKKYQTLGGEIEKIHVEISKYKDEMTKTNYTLDEMYENNI KYYMELEKYVVAGQMKLEEMQSILPSYEEKAASGNQLAQMQLDTLRNGIQALEERVYD LDMARMVALQTAPQIRLLQRGNAKLIGKINSAFIITIPIFKNGIIQAVTVKRQKLVAD SMSELDRRTNEMLKRNAENISSQSVEIARMAGRPSIDIETIESSWNTIVSGMQETKQI EEENKRLREDGARRIAQLQDNIKKAALQQ*" /label="yceH CDS" gene 298079..299170 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /label="yceH gene" downshifts 299144 /Source="Nicolas_upshifts" /id="D122" /incds=0 /nref=85 /ntot=228 /MaxReadThrough="4.46836" /MaxDrop="4.05585" /score="-6.59172775" /energy="-17.5" /TU="U212" /idTUdmin="U212" /TUdmin="-1322" /isTUend="FALSE" /label="downshifts" promotor_-35 299224..299231 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 299246..299265 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 299254 /Source="Nicolas_upshifts" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="upshifts" CDS 299292..300494 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18276644, 21953179" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18276644, 21953179; Product type t: transporter" /codon_start=1 /transl_table=11 /product="niacin permease" /protein_id="NP_388177.1" /db_xref="EnsemblGenomes-Gn:BSU02950" /db_xref="EnsemblGenomes-Tr:CAB12089" /db_xref="GOA:O34691" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12773" /db_xref="UniProtKB/Swiss-Prot:O34691" /translation="MGKQQPISQRKLLGVAGLGWLFDAMDVGILSFIIAALHVEWNLS PEEMKWIGSVNSIGMAAGAFLFGLLADRIGRKKVFIITLLCFSIGSGISAFVTSLSAF LILRFVIGMGLGGELPVASTLVSEAVVPEKRGRVIVLLESFWAVGWLAAALISYFVIP SFGWQAALLLTALTAFYALYLRTSLPDSPKYESLSAKKRSMWENVKSVWARQYIRPTV MLSIVWFCVVFSYYGMFLWLPSVMLLKGFSMIQSFEYVLLMTLAQLPGYFSAAWLIEK AGRKWILVVYLIGTAGSAYFFGTADSLSLLLTAGVLLSFFNLGAWGVLYAYTPEQYPT AIRATGSGTTAAFGRIGGIFGPLLVGTLAARHISFSVIFSIFCIAILLAVACILIMGK ETKQTELE*" /label="niaP CDS" gene 299292..300494 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /label="niaP gene" downshifts 300474 /Source="Nicolas_upshifts" /id="D123" /incds=0 /nref=8 /ntot=184 /MaxReadThrough="4.1968" /MaxDrop="3.48367" /score="13.0427769" /energy="-10.6" /TU="U213" /idTUdmin="U212" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(300747..301919) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate transporter (possibly exporter)" /protein_id="NP_388178.1" /db_xref="EnsemblGenomes-Gn:BSU02960" /db_xref="EnsemblGenomes-Tr:CAB12090" /db_xref="GOA:O34724" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12774" /db_xref="UniProtKB/Swiss-Prot:O34724" /translation="MNRIWLFFSVMFVIGTDTFLLSPLLPLLQDQFHVSTDLSGWMVS AYALGYALFAFIAGPISDRLNRKTVMLWGLAGFIVSTFLCGIAPSFAAMCLFRFAAGV SAAFVTPQIWASIPVIVQPSQIIKGMGIATAGLAASQMLGLPIGGFLASFTWHTPFFV LSACSLILLLILAAVMPGIRPSEPLARPSIVNPYRELFSLPKTSVILLAYFLFQTGNF ASFSFLGTWLSADYHLTVSQIGAAMLVLGLGNMLGSLIGSRVSEKLGMFKTLISGMLL MGALYFALPFFPNLFLVEAGFFLTFFTAGIIFPLMMGVFQSIAPNARGTIASLSNAAM YAGTTVGTSIAGFLYQSTQHFGAVTGFTAILFILSMTLYQTISKTGKRQSTARAQL*" /label="yceJ CDS" gene complement(300747..301919) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /label="yceJ gene" downshifts complement(300762) /Source="Nicolas_upshifts" /id="D124" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="2.6211" /MaxDrop="2.7452" /score="9.21991741" /energy="-12.6" /TU="NA" /idTUdmin="U214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(301988..302290) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388179.1" /db_xref="EnsemblGenomes-Gn:BSU02970" /db_xref="EnsemblGenomes-Tr:CAB12091" /db_xref="GOA:O34464" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12775" /db_xref="UniProtKB/Swiss-Prot:O34464" /translation="MYYSFMTMKQSDDQIRAQIFKALSDESRLAIIRTLYVSGKELSC GEVGEKCNIVKTTASYHFKTLREAGLTATRKDSRTKYVSLREDTFQTYLPGFLETL*" /label="yceK CDS" gene complement(301988..302290) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /label="yceK gene" downshifts complement(302016) /Source="Nicolas_upshifts" /id="D125" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="5.67096" /MaxDrop="6.89889" /score="2.01231069" /energy="-4.8" /TU="U214" /idTUdmin="U214" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(302273..302292) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(302292) /Source="Nicolas_upshifts" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(302306..302312) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 302539..302558 /Source="Nicolas_upshift_promotors" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 302539 /Source="Nicolas_upshifts" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="upshifts" CDS 302580..303836 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(ATP-binding protein)" /protein_id="NP_388180.2" /db_xref="EnsemblGenomes-Gn:BSU02980" /db_xref="EnsemblGenomes-Tr:CAB12092" /db_xref="GOA:P46920" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11370" /db_xref="UniProtKB/Swiss-Prot:P46920" /translation="MSVDEKPIKIKVEKVSKIFGKQTKKAVQMLANGKTKKEILKATG STVGVNQADFEVYDGEIFVIMGLSGSGKSTLVRMLNRLIEPTAGNIYIDGDMITNMSK DQLREVRRKKISMVFQKFALFPHRTILENTEYGLELQGVDKQERQQKALESLKLVGLE GFEHQYPDQLSGGMQQRVGLARALTNDPDILLMDEAFSALDPLIRKDMQDELLDLHDN VGKTIIFITHDLDEALRIGDRIVLMKDGNIVQIGTPEEILMNPSNEYVEKFVEDVDLS KVLTAGHIMKRAETVRIDKGPRVALTLMKNLGISSIYAVDKQKKLLGVIYASDAKKAA ESDLSLQDILNTEFTTVPENTYLTEIFDVVSDANIPIAVVDEKQRMKGIVVRGALIGA LAGNNEYINAEGTNEQTQDPSAQEVK*" /label="opuAA CDS" gene 302580..303836 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /label="opuAA gene" downshifts complement(302588) /Source="Nicolas_upshifts" /id="D126" /incds=0 /nref=108 /ntot=175 /MaxReadThrough="2.83797" /MaxDrop="5.18503" /score="2.01231069" /energy="-4.8" /TU="NA" /idTUdmin="U214" /TUdmin="-1826" /isTUend="FALSE" /label="downshifts" CDS 303838..304686 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752321, 15849754, 16225868, 16645306, 16850406, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752321, 15849754, 16225868, 16645306, 16850406, 25012968; Product type t : transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(permease)" /protein_id="NP_388181.1" /db_xref="EnsemblGenomes-Gn:BSU02990" /db_xref="EnsemblGenomes-Tr:CAB12093" /db_xref="GOA:P46921" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11371" /db_xref="UniProtKB/Swiss-Prot:P46921" /translation="MDRLPRIPLADIIDRFVDWITMTFGGFFDGIANGLAAFVNGIVT GLGFIPSILLTIIFAALAWWISTRGIALFTLIGFLLIDYLGYWDPMLQTLALVLTSVI ISIVVGVPIGIWASQKETVRRIVTPILDLMQTMPAFVYLLPAIFFFNIGVVPGVVASV IFAMPPTIRMTVLGIKQVPADLIEATEAFGSTTAQRLFKVQLPLATKTILAGINQSIM LALSMVVIAAMVGAPGLGSEVYSAVTQLKTGVGVEAGIAIVIVAITLDRITQNIKVKK KSRGNA*" /label="opuAB CDS" gene 303838..304686 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /label="opuAB gene" CDS 304686..305567 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporterABC transporter (glycine betaine-binding lipoprotein)" /protein_id="NP_388182.1" /db_xref="EnsemblGenomes-Gn:BSU03000" /db_xref="EnsemblGenomes-Tr:CAB12094" /db_xref="GOA:P46922" /db_xref="InterPro:IPR007210" /db_xref="PDB:2B4L" /db_xref="PDB:2B4M" /db_xref="PDB:3CHG" /db_xref="SubtiList:BG11372" /db_xref="UniProtKB/Swiss-Prot:P46922" /translation="MLKKIIGIGVSAMLALSLAACGSENDENASAAEQVNKTIIGIDP GSGIMSLTDKAMKDYDLNDWTLISASSAAMTATLKKSYDRKKPIIITGWTPHWMFSRY KLKYLDDPKQSYGSAEEIHTITRKGFSKEQPNAAKLLSQFKWTQDEMGEIMIKVEEGE KPAKVAAEYVNKHKDQIAEWTKGVQKVKGDKINLAYVAWDSEIASTNVIGKVLEDLGY EVTLTQVEAGPMWTAIATGSADASLSAWLPNTHKAYAAKYKGKYDDIGTSMTGVKMGL VVPQYMKNVNSIEDLKK*" /label="opuAC CDS" gene 304686..305567 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /label="opuAC gene" downshifts 305548 /Source="Nicolas_upshifts" /id="D127" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="0.74967" /MaxDrop="8.21394" /score="33.6263027" /energy="-12.2" /TU="NA" /idTUdmin="U215" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(305580) /Source="Nicolas_upshifts" /id="D128" /incds=0 /nref=2 /ntot=62 /MaxReadThrough="4.29566" /MaxDrop="3.9514" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(305605..306756) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8768514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388183.2" /db_xref="EnsemblGenomes-Gn:BSU03010" /db_xref="EnsemblGenomes-Tr:CAB12095" /db_xref="GOA:P54983" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11789" /db_xref="UniProtKB/Swiss-Prot:P54983" /translation="MQKLSEEMKQTIMDIFEHLHANPEVSWKEYETTSFLKQKLEDLG CRTRTFSDCTGVVGEIGSGSPVVAVRADIDALWQEVNGTFRANHSCGHDSHMTMALGT LMLLKKQPELPKGTIRFIFQPAEEKGGGALKMIEEGVLDDIDYLYGVHVRPIQETQNG RCAPSILHGSSQHIEGTIIGEEAHGARPHLGKNSIEIAAFLVHKLGLIHIDPQIPHTV KMTKLQAGGESSNIIPGKASFSLDLRAQTNEAMEALIAETERACEAAAAAFGAKIELH KEHSLPAATQNKEAEAIMAEAITEIIGAERLDDPLVTTGGEDFHFYAVKVPNLKTTML GLGCGLQPGLHHPHMTFDRNAMFTGIHILANAVLKTFQKAESLAAANAS*" /label="amhX CDS" gene complement(305605..306756) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /label="amhX gene" downshifts complement(305624) /Source="Nicolas_upshifts" /id="D129" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="4.33606" /MaxDrop="3.5225" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" S_feature complement(306757..306844) /Source="Nicolas_S_feature" /locus_tag="new_325190_325277_c" /HighExp="Etha, T1.30H, M9-stat, T2.30H, S1, T3.30H, T5.0H, T4.0H, Sw, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S107" promotor_-35 306812..306819 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-35" promotor_-10 complement(306831..306850) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 306834..306853 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-10" upshifts complement(306844) /Source="Nicolas_upshifts" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="upshifts" upshifts 306847 /Source="Nicolas_upshifts" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="upshifts" promotor_-35 complement(306863..306869) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 306906..308339 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21747963, 21764931; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative branched chain amino acid permease" /protein_id="NP_388184.2" /db_xref="EnsemblGenomes-Gn:BSU03020" /db_xref="EnsemblGenomes-Tr:CAB12096" /db_xref="GOA:P55908" /db_xref="InterPro:IPR018385" /db_xref="SubtiList:BG11999" /db_xref="UniProtKB/Swiss-Prot:P55908" /translation="MSMPAAETQPKKKRMTFKMPDAYVLLFMIAFICAIASYIVPAGE FDRVTKGDVTTAVPGSYHSIEQSPVRLISFFTSLQDGMVGSAPIIFLILFTGGTIAIL EKTGAINGLIYNVISKFRTKQLLFICIVGALFSILGTTGIVVNSVIGFIPIGLIVARS LKWDAVAGAAVIYIGCYAGFNSTILSPSPLGLSQSIAELPLFSGIGLRVVIYICFLLS SIIYIYLYTRKLKKSKDASVLGTDWFPAAGMGEAGKEEDQSVPFTVRHKLILAVAGLS LVGFLYGALKLGWSDSQMAATFIFISVLAGLIGGLAANDIAKTFITGCQSLVYGALIV GMARSISVILENGKLLDTVVNALASLLDGFSPIAGAIGMYIASALLHFLISSGSGEAV VFIPILAPLADLMGITRQVAVEAVMLGEGVVNCVNPTSGVLMAVLAASGIPYVKWLRF MVPLALIWFLIGLVFIVIGVMINWGPF*" /label="ycgA CDS" gene 306906..308339 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /label="ycgA gene" promotor_-35 307644..307652 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 307664..307682 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 307683 /Source="Nicolas_upshifts" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 308321 /Source="Nicolas_upshifts" /id="D130" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="3.53497" /MaxDrop="3.31444" /score="12.0135493" /energy="-15.6" /TU="U217" /idTUdmin="U218" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 308382..308389 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 308404..308423 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 308413 /Source="Nicolas_upshifts" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 308455..309036 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406, 22720735; Producttype m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_388185.2" /db_xref="EnsemblGenomes-Gn:BSU03030" /db_xref="EnsemblGenomes-Tr:CAB12097" /db_xref="SubtiList:BG12000" /db_xref="UniProtKB/Swiss-Prot:P55909" /translation="MNNLRNRLSGVNGKNKRVKEKEQKIWSEIGMIAGAFALLDVIIR GIMFEFPFKEWAASLVFLFIIILYYCIRAAASGMLMPRIDTKEELQKRVKQQRIESIA VAFAVVVLTMYDRGIPHTFFAWLKMILLFIVCGGVLFLLRYVIVKLAYRRAVKEEIKK KSSFLFGKRGKRSQFRAAFFIGTLICIHSAKLF*" /label="ycgB CDS" gene 308455..309036 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /label="ycgB gene" upshifts 308849 /Source="Nicolas_upshifts" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" misc_feature 308853..308857 /Source="Nicolas_upshift_promotors" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 309012..309019 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 309034..309053 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 309047..309184 /Source="Nicolas_S_feature" /locus_tag="new_327480_327617" /HighExp="BC, M0t90, M40t90, S2, M9-stat, T4.0H, Sw, T3.30H, Lbtran, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.999, 0.242, 0.999" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S108" upshifts 309047 /Source="Nicolas_upshifts" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 309185..311164 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /EC_number="3.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3117969, 9353930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3117969, 9353930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-amylase" /protein_id="NP_388186.2" /db_xref="EnsemblGenomes-Gn:BSU03040" /db_xref="EnsemblGenomes-Tr:CAB12098" /db_xref="GOA:P00691" /db_xref="InterPro:IPR006046" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR031319" /db_xref="InterPro:IPR031965" /db_xref="PDB:1BAG" /db_xref="PDB:1UA7" /db_xref="SubtiList:BG10473" /db_xref="UniProtKB/Swiss-Prot:P00691" /translation="MFAKRFKTSLLPLFAGFLLLFHLVLAGPAAASAETANKSNELTA PSIKSGTILHAWNWSFNTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWL YQPTSYQIGNRYLGTEQEFKEMCAAAEEYGIKVIVDAVINHTTSDYAAISNEVKSIPN WTHGNTQIKNWSDRWDVTQNSLLGLYDWNTQNTQVQSYLKRFLDRALNDGADGFRFDA AKHIELPDDGSYGSQFWPNITNTSAEFQYGEILQDSASRDAAYANYMDVTASNYGHSI RSALKNRNLGVSNISHYASDVSADKLVTWVESHDTYANDDEESTWMSDDDIRLGWAVI ASRSGSTPLFFSRPEGGGNGVRFPGKSQIGDRGSALFEDQAITAVNRFHNVMAGQPEE LSNPNGNNQIFMNQRGSHGVVLANAGSSSVSINTATKLPDGRYDNKAGAGSFQVNDGK LTGTINARSVAVLYPDDIAKAPHVFLENYKTGVTHSFNDQLTITLRADANTTKAVYQI NNGPETAFKDGDQFTIGKGDPFGKTYTIMLKGTNSDGVTRTEKYSFVKRDPASAKTIG YQNPNHWSQVNAYIYKHDGSRVIELTGSWPGKPMTKNADGIYTLTLPADTDTTNAKVI FNNGSAQVPGQNQPGFDYVLNGLYNDSGLSGSLPH*" /label="amyE CDS" gene 309185..311164 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /label="amyE gene" downshifts 311178 /Source="Nicolas_upshifts" /id="D131" /incds=0 /nref=57 /ntot=131 /MaxReadThrough="1.64783" /MaxDrop="6.55823" /score="-8.82332571" /energy="-3.4" /TU="U221" /idTUdmin="U219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 311244..311251 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 311261 /Source="Nicolas_upshifts" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 311265..311284 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 311341..312306 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /EC_number="1.1.1.27" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10809684, 16207915, 19383131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 16207915, 19383131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lactate dehydrogenase" /protein_id="NP_388187.2" /db_xref="EnsemblGenomes-Gn:BSU03050" /db_xref="EnsemblGenomes-Tr:CAB12099" /db_xref="GOA:P13714" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011304" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR018177" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="PDB:3PQD" /db_xref="PDB:3PQE" /db_xref="PDB:3PQF" /db_xref="SubtiList:BG19003" /db_xref="UniProtKB/Swiss-Prot:P13714" /translation="MMNKHVNKVALIGAGFVGSSYAFALINQGITDELVVIDVNKEKA MGDVMDLNHGKAFAPQPVKTSYGTYEDCKDADIVCICAGANQKPGETRLELVEKNLKI FKGIVSEVMASGFDGIFLVATNPVDILTYATWKFSGLPKERVIGSGTTLDSARFRFML SEYFGAAPQNVHAHIIGEHGDTELPVWSHANVGGVPVSELVEKNDAYKQEELDQIVDD VKNAAYHIIEKKGATYYGVAMSLARITKAILHNENSILTVSTYLDGQYGADDVYIGVP AVVNRGGIAGITELNLNEKEKEQFLHSAGVLKNILKPHFAEQKVN*" /label="lctE CDS" gene 311341..312306 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /label="lctE gene" CDS 312338..313963 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10809684, 15849754, 16428414, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 15849754, 16428414, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_388188.2" /db_xref="EnsemblGenomes-Gn:BSU03060" /db_xref="EnsemblGenomes-Tr:CAB12100" /db_xref="GOA:P55910" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG12001" /db_xref="UniProtKB/Swiss-Prot:P55910" /translation="MWEQLYDPFGNEYVSALVALTPILFFLLALTVLKMKGILAAFLT LAVSFFVSVWAFHMPVEKAISSVLLGIGSGLWPIGYIVLMAVWLYKIAVKTGKFTIIR SSIAGISPDQRLQLLLIGFCFNAFLEGAAGFGVPIAISAALLVELGFKPLKAAALCLI ANAASGAFGAIGIPVITGAQIGDLSALELSRTLMWTLPMISFLIPFLLVFLLDRMKGI KQTWPALLVVSGGYTAVQTLTMAVLGPELANILAALFSMGGLALFLRKWQPKEIYREE GAGDAGEKKAYRAADIAKAWSPFYILTAAITIWSLPAFKALFQEGGLLYQSTLLFKMP FLHQQIMKMPPIAPSAMPLDAVFKVDLLSATGTAILAAVIVTGLFSKKFSSRDAFASL KETGKELWVPIMTICFVMGFANLANFAGLSSSIGLALAKTGDLFPFVSPVLGWIGVFI TGSVVSNNALFGHLQVVTGAQIGAGSDLLLAANTAGGVMAKLVSPQSIAIAAAAVGQT GKESKLFKRTVAYSLILLLIICIWTFILARLGV*" /label="lctP CDS" gene 312338..313963 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /label="lctP gene" downshifts 312344 /Source="Nicolas_upshifts" /id="D132" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="8.56142" /MaxDrop="2.8862" /score="-8.82332571" /energy="-3.4" /TU="U222" /idTUdmin="U221" /TUdmin=1144 /isTUend="FALSE" /label="downshifts" downshifts 313950 /Source="Nicolas_upshifts" /id="D133" /incds=0 /nref=51 /ntot=118 /MaxReadThrough="2.31168" /MaxDrop="7.73065" /score="39.575264" /energy="-15.6" /TU="NA" /idTUdmin="U222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(314008..315546) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9023234, 15489457, 15849754, 16850406, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023234, 15489457, 15849754, 16850406, 21690368; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_388189.2" /db_xref="EnsemblGenomes-Gn:BSU03070" /db_xref="EnsemblGenomes-Tr:CAB12101" /db_xref="GOA:P96712" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12002" /db_xref="UniProtKB/Swiss-Prot:P96712" /translation="MDTTTAKQASTKFVVLGLLLGILMSAMDNTIVATAMGNIVADLG SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLIFFLIGSALCGIAQTMNQ LIIFRAIQGIGGGALLPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGAIIT DSISWHWVFYINVPIGALSLFFIIRYYKESLEHRKQKIDWGGAITLVVSIVCLMFALE LGGKTYDWNSIQIIGLFIVFAVFFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFL YGGTFIILAVFIPIFVQAVYGSSATSAGFILTPMMIGSVIGSMIGGIFQTKASFRNLM LISVIAFFIGMLLLSNMTPDTARVWLTVFMMISGFGVGFNFSLLPAASMNDLEPRFRG TANSTNSFLRSFGMTLGVTIFGTVQTNVFTNKLNDAFSGMKGSAGSGAAQNIGDPQEI FQAGTRSQIPDAILNRIIDAMSSSITYVFLLALIPIVLAAVTILFMGKARVKTTAEMT KKAN*" /label="mdr CDS" gene complement(314008..315546) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /label="mdr gene" downshifts complement(314026) /Source="Nicolas_upshifts" /id="D134" /incds=0 /nref=70 /ntot=182 /MaxReadThrough="1.04964" /MaxDrop="4.53635" /score="30.8374042" /energy="-15.6" /TU="NA" /idTUdmin="U225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(314600..314700) /Source="Nicolas_upshift_promotors" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(314640) /Source="Nicolas_upshifts" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 315560..315564 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 315580..315599 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 315594 /Source="Nicolas_upshifts" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(315626..315645) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(315629) /Source="Nicolas_upshifts" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="upshifts" CDS 315659..316123 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388190.2" /db_xref="EnsemblGenomes-Gn:BSU03080" /db_xref="EnsemblGenomes-Tr:CAB12102" /db_xref="GOA:O31472" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12003" /db_xref="UniProtKB/Swiss-Prot:O31472" /translation="MSTRNSRSELEKTAVQLFRKLGTRTVLFHQAAAQALGLFPTDLK SADILNEAGPMTAGELGKKTGLSTGSVTALVDRLEKAGYVAREKDPNDRRRVVIVPLT ASKKHIKDLFRPLSESTMDLCREYTEEELELIFSFVGKAADIMEEELERLKQ*" /label="ycgE CDS" gene 315659..316123 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /label="ycgE gene" promotor_-35 complement(315660..315666) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 316133..316138 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316154..316172 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316164 /Source="Nicolas_upshifts" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 316197..316826 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid export permease" /protein_id="NP_388191.1" /db_xref="EnsemblGenomes-Gn:BSU03090" /db_xref="EnsemblGenomes-Tr:CAB12103" /db_xref="GOA:P94381" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG12004" /db_xref="UniProtKB/Swiss-Prot:P94381" /translation="MNIFLSYIVLGLSLSAPVGPVNAAQIDKGIKNGFWHAWIFGLGA MTADGLYMLFIYFGLSQFLTAPFVKTFLWLFGFFVLTYTGIETLKNVREPMDVRSSRG KPSYRKTFASGFLISLSNPLSILFWLGIYGSILAKTAEAYNMNQLLIYSSGIMIGILI WDFCMAITASTFRNLLHEKLLRGLTGIAGVSLLVFGFYFGYQGIKQLLG*" /label="ycgF CDS" gene 316197..316826 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /label="ycgF gene" promotor_-35 316837..316846 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316860..316879 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316868 /Source="Nicolas_upshifts" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 316896..317657 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (similar to phage protein)" /protein_id="NP_388192.2" /db_xref="EnsemblGenomes-Gn:BSU03100" /db_xref="EnsemblGenomes-Tr:CAB12104" /db_xref="InterPro:IPR014988" /db_xref="SubtiList:BG12005" /db_xref="UniProtKB/Swiss-Prot:P94382" /translation="MVNGIYTKSFLERIQEELPEWQRIAFELLAETLGDDADTFPCIP GRQAFLTDQLRIAFAGDPRENRTAEELAPLLAEYGKISRDTGKYASLVVLFDTPEDLA EHYSIEAYEELFWRFLNRLSHQDEKEWPEDIPADPEHYKWEFCFDGEPYFILCATPGH EARRSRSFPFFMVTFQPRWVFDDLNGSTAFGRNMSRLIRSRLEAYDQAPIHPQLGWYG GKDNREWKQYFLRDDEKQVSKCPFSYLKNMFNKMK*" /label="ycgG CDS" gene 316896..317657 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /label="ycgG gene" S_feature complement(317296..317658) /Source="Nicolas_S_feature" /locus_tag="new_335729_336091_c" /HighExp="S8, S7, S5, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="ycgG" /AntisenseCor="0.73875580854115197" /AntisenseRegPval="-46.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S109" downshifts 317654 /Source="Nicolas_upshifts" /id="D135" /incds=0 /nref=21 /ntot=174 /MaxReadThrough="1.53211" /MaxDrop="4.92685" /score="6.36985882" /energy="-8.6" /TU="NA" /idTUdmin="U227" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(317659..318999) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid transporter" /protein_id="NP_388193.2" /db_xref="EnsemblGenomes-Gn:BSU03110" /db_xref="EnsemblGenomes-Tr:CAB12105" /db_xref="GOA:P94383" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12006" /db_xref="UniProtKB/Swiss-Prot:P94383" /translation="MSQTKKDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGF SVLLSFLIAGIGTYFVFEQLAKLSAKQPEKGSFCAYARKAFGKWAGFSNGWVYWTSEM LITGSQLTAISLFTKHWFPQVPLWVFASIYAVLGLLIIFTGLSVFEKTENVLAVIKTA AIFMFIVIAILALCGILSGGNHGIHVPNKTSEFFPYGAMGLWTGLIYAFYAFGGIEVM GLMAVHLKKPEEASKSGKLMLATLAIIYIISIGLALLLVPLHTFTEQDSPFITSLKGY NLEIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFTLKEGKKICWPAL GLTFAGLVLSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSSKKLTDPEGMGKTQI YLAMVLIAAAVSGTLFEKSSRPGFFVSIGFLVIIAIVTMIYQKKQGHKDRPASP*" /label="ycgH CDS" gene complement(317659..318999) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /label="ycgH gene" promotor_-10 complement(319026..319037) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(319036) /Source="Nicolas_upshifts" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(319052..319058) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 319078..319084 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 319092 /Source="Nicolas_upshifts" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 319099..319110 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 319129..319725 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16433904, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388194.3" /db_xref="EnsemblGenomes-Gn:BSU03120" /db_xref="EnsemblGenomes-Tr:CAB12106" /db_xref="InterPro:IPR018959" /db_xref="SubtiList:BG12007" /db_xref="UniProtKB/Swiss-Prot:O31473" /translation="MTQQYIVEPKKGLGLKLKKGQILKVVDVEGQQVADFVAYHAKDF YEHLDQGATIDANHSIHVKVNDHLYSNLYKPMLTLIEDTVGKHDLLLPACRPDMNRLL YGKQKDEFQDTCYDNMNRALEQFGVPKPHMHYPFAIFMNTVLDEKGNLSVETPLSNAG DYVRLRAEMDLIVAFSSCPIEKGKCNGDSVTSIRVEVS*" /label="ycgI CDS" gene 319129..319725 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /label="ycgI gene" promotor_-35 319733..319740 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 319754..319854 /Source="Nicolas_S_feature" /locus_tag="new_338187_338287" /HighExp="dia15, LBGtran, dia5, Etha, dia0, LBGexp, M0t45, Lbexp, Diami, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S110" promotor_-10 319754..319773 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 319754 /Source="Nicolas_upshifts" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(319850) /Source="Nicolas_upshifts" /id="D136" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="1.2989" /MaxDrop="4.67402" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS 319855..320673 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /EC_number="6.3.1.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7890752, 9271869, 12682299, 19204287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7890752, 9271869, 12682299, 19204287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ammonium-dependent NAD+ synthetase" /protein_id="NP_388195.1" /db_xref="EnsemblGenomes-Gn:BSU03130" /db_xref="EnsemblGenomes-Tr:CAB12107" /db_xref="GOA:P08164" /db_xref="InterPro:IPR003694" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022926" /db_xref="PDB:1EE1" /db_xref="PDB:1FYD" /db_xref="PDB:1IFX" /db_xref="PDB:1IH8" /db_xref="PDB:1KQP" /db_xref="PDB:1NSY" /db_xref="PDB:2NSY" /db_xref="SubtiList:BG10694" /db_xref="UniProtKB/Swiss-Prot:P08164" /translation="MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVL GISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDK SWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDH AAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQ QSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK*" /label="nadE CDS" gene 319855..320673 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /label="nadE gene" downshifts 320655 /Source="Nicolas_upshifts" /id="D137" /incds=0 /nref=144 /ntot=271 /MaxReadThrough="2.68866" /MaxDrop="6.24927" /score="20.6612287" /energy="-14.1" /TU="U230" /idTUdmin="U230" /TUdmin="-65" /isTUend="FALSE" /label="downshifts" CDS complement(320723..321316) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1624425, 7766032, 15131133, 27315722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624425, 7766032, 15131133, 27315722; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATP-binding tunicamycin resistance protein" /protein_id="NP_388196.2" /db_xref="EnsemblGenomes-Gn:BSU03140" /db_xref="EnsemblGenomes-Tr:CAB12108" /db_xref="GOA:P12921" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10456" /db_xref="UniProtKB/Swiss-Prot:P12921" /translation="MIIWINGAFGSGKTQTAFELHRRLNPSYVYDPEKMGFALRSMVP QEIAKDDFQSYPLWRAFNYSLLASLTDTYRGILIVPMTIVHPEYFNEIIGRLRQEGRI VHHFTLMASKETLLKRLRTRAEGKNSWAAKQIDRCVEGLSSPIFEDHIQTDNLSIQDV AENIAARAELPLDPDTRGSLRRFADRLMVKLNHIRIK*" /label="tmrB CDS" gene complement(320723..321316) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /label="tmrB gene" downshifts complement(320730) /Source="Nicolas_upshifts" /id="D138" /incds=0 /nref=10 /ntot=143 /MaxReadThrough="0.60282" /MaxDrop="3.74815" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(321331..321350) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(321346) /Source="Nicolas_upshifts" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(321365..321368) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(321374..321522) /Source="Nicolas_S_feature" /locus_tag="new_339807_339955_c" /HighExp="S4, S3, S6, S5, S7, BT, S8, LoTm, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S111" promotor_-35 321424..321431 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 321444..321463 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 321446..321554 /Source="Nicolas_S_feature" /locus_tag="new_339879_339987" /HighExp="Diami, BMM, GM 15, GM 25, GM 120, GM 60, GM 10, G180, GM 45, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S112" upshifts 321448 /Source="Nicolas_upshifts" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(321516..321534) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 321522..321529 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(321532) /Source="Nicolas_upshifts" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 321544..321563 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(321550..321555) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 321556 /Source="Nicolas_upshifts" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="upshifts" CDS 321592..322152 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /EC_number="2.7.1.71" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 170268, 7612934, 27339308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate kinase" /protein_id="NP_388197.2" /db_xref="EnsemblGenomes-Gn:BSU03150" /db_xref="EnsemblGenomes-Tr:CAB12109" /db_xref="GOA:P37944" /db_xref="InterPro:IPR000623" /db_xref="InterPro:IPR023000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031322" /db_xref="SubtiList:BG10457" /db_xref="UniProtKB/Swiss-Prot:P37944" /translation="MNAKRAIPVRERNIVLIGFMGVGKTTIGQLVAKKLYRDFIDIDQ QIEKDFNMSIPEIFEKKGEDFFRKTEKEYILDICHHKRFKIVSLGGGSFKQEEIRNCC LENCLVLHLDLSWENWKQRADLLIESRPVLHNRSMDEMEQLFNERKVIYDKHNSKVAT DNLSPEEVADYIVETLKIGWDLYQPM*" /label="aroK CDS" gene 321592..322152 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /label="aroK gene" downshifts 322129 /Source="Nicolas_upshifts" /id="D139" /incds=0 /nref=21 /ntot=239 /MaxReadThrough="2.07607" /MaxDrop="4.67156" /score="44.9099474" /energy="-13.1" /TU="NA" /idTUdmin="U232" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(322180..322941) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388198.2" /db_xref="EnsemblGenomes-Gn:BSU03160" /db_xref="EnsemblGenomes-Tr:CAB12110" /db_xref="GOA:O31474" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XXL" /db_xref="PDB:2GLU" /db_xref="SubtiList:BG12008" /db_xref="UniProtKB/Swiss-Prot:O31474" /translation="MTNETPFSKNAEMYRDEKVFAEGEDLGLMIKTAECRAEHRVLDI GAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPFPDD SFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFVNHLNRLR DPSHVRESSLSEWQAMFSANQLAYQDIQKWNLPIQYDSWIKRGGTPADREKQIITHLN HASDEARDTFCITLNQNGQPISFCLKAILIQGIKR*" /label="ycgJ CDS" gene complement(322180..322941) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /label="ycgJ gene" downshifts complement(322204) /Source="Nicolas_upshifts" /id="D140" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.31391" /MaxDrop="3.85249" /score="18.9843263" /energy="-13.1" /TU="NA" /idTUdmin="U235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(322973..322992) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 322974..322981 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(322979) /Source="Nicolas_upshifts" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 322996..323015 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(323007..323012) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 323008 /Source="Nicolas_upshifts" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" CDS 323059..324033 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_388199.2" /db_xref="EnsemblGenomes-Gn:BSU03170" /db_xref="EnsemblGenomes-Tr:CAB12111" /db_xref="GOA:P94387" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12009" /db_xref="UniProtKB/Swiss-Prot:P94387" /translation="MDIKVMEYAAEIARRQSFTKAAEHLHIAQPSLSQQIKKLEAELG LTLFHRSHGSVTLTPHGRRFIEKAEDIIRSRDDLLREMQERSQGIGHKLSIGIPAVTG RYLFPPLLKQFLARYPHVEVQLVEKDPVSLEKMTAKGEVDLSVLSLPIEDERLSITPL LTEPVVLAVPKEKQRWMPPELVALIEKALEEDEGRQPCVPIDMVRNVPFILLKEGFGF RRTVLDLCAESGFKPNAAFKTSHIETAQSLVANGLGVTMAPNMVRRDKDPGVIYLSIQ SAPSRTLVFVFLKNRYVSLTAQAFMELSRESLKQTFDEGCLGNKDENI*" /label="ycgK CDS" gene 323059..324033 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /label="ycgK gene" S_feature 324034..324104 /Source="Nicolas_S_feature" /locus_tag="new_342467_342537" /HighExp="Diami, dia5, dia15, S1, dia0, C90, LBGexp, Heat, Lbexp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S113" CDS 324105..325061 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /EC_number="3.1.1.41" /EC_number="3.1.1.72" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12842474, 19837798, 21382014" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12842474, 19837798, 21382014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acetyl xylan esterase-cephalosporin C deacetylase" /protein_id="NP_388200.1" /db_xref="EnsemblGenomes-Gn:BSU03180" /db_xref="EnsemblGenomes-Tr:CAB12112" /db_xref="GOA:P94388" /db_xref="InterPro:IPR008391" /db_xref="InterPro:IPR029058" /db_xref="PDB:1L7A" /db_xref="PDB:1ODS" /db_xref="PDB:1ODT" /db_xref="SubtiList:BG11919" /db_xref="UniProtKB/Swiss-Prot:P94388" /translation="MQLFDLPLDQLQTYKPEKTAPKDFSEFWKLSLEELAKVQAEPDL QPVDYPADGVKVYRLTYKSFGNARITGWYAVPDKEGPHPAIVKYHGYNASYDGEIHEM VNWALHGYATFGMLVRGQQSSEDTSISPHGHALGWMTKGILDKDTYYYRGVYLDAVRA LEVISSFDEVDETRIGVTGGSQGGGLTIAAAALSDIPKAAVADYPYLSNFERAIDVAL EQPYLEINSFFRRNGSPETEVQAMKTLSYFDIMNLADRVKVPVLMSIGLIDKVTPPST VFAAYNHLETKKELKVYRYFGHEYIPAFQTEKLAFFKQHLKG*" /label="cah CDS" gene 324105..325061 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /label="cah gene" promotor_-35 324520..324526 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 324541..324552 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 324548 /Source="Nicolas_upshifts" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" S_feature 325062..325140 /Source="Nicolas_S_feature" /locus_tag="new_343495_343573" /HighExp="dia5, dia15, Diami, dia0, B36, S1, MG 10, BT, B60, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S114" promotor_-35 325115..325120 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 325137..325155 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 325142 /Source="Nicolas_upshifts" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" CDS 325145..325927 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388201.1" /db_xref="EnsemblGenomes-Gn:BSU03190" /db_xref="EnsemblGenomes-Tr:CAB12113" /db_xref="InterPro:IPR018775" /db_xref="SubtiList:BG12010" /db_xref="UniProtKB/Swiss-Prot:P94389" /translation="MKQRIIDELKRIEQSYGVKIVYAVESGSRAWGFPSQDSDYDVRF IYVPKKEWYFSIEQERDVIEEPIHDLLDISGWELRKTLRLFKKSNPPLLEWLSSDIVY YEAFTTAEQLRKLRTEAFKPEASVYHYINMARRNVKDYLQGQEVKIKKYFYVLRPILA CQWIEKHGTIPPMDFTVLMNELVAEPELKAEMETLLERKRRGEELDLEARIDVIHQFI ETEIERIMEAAKELKAEKKDMTSELNRLLLNTVEEVWKDGGS*" /label="ycgL CDS" gene 325145..325927 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /label="ycgL gene" downshifts 325892 /Source="Nicolas_upshifts" /id="D141" /incds=0 /nref=11 /ntot=63 /MaxReadThrough="3.94077" /MaxDrop="4.37398" /score="0.421649027" /energy="-5.9" /TU="U238" /idTUdmin="U236" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 325937..326064 /Source="Nicolas_S_feature" /locus_tag="new_344370_344497" /HighExp="S5, S6, S8, S4, S7, B36, B60, BT, S3, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S115" promotor_-35 326041..326045 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326060..326079 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326066 /Source="Nicolas_upshifts" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 326118..327029 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /EC_number="1.5.5.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17536821, 2118500, 21840319, 22139509, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17536821, 2118500, 21840319, 22139509, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline oxidase" /protein_id="NP_388202.1" /db_xref="EnsemblGenomes-Gn:BSU03200" /db_xref="EnsemblGenomes-Tr:CAB12114" /db_xref="GOA:P94390" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG12011" /db_xref="UniProtKB/Swiss-Prot:P94390" /translation="MITRDFFLFLSKSGFLNKMARNWGSRVAAGKIIGGNDFNSSIPT IRQLNSQGLSVTVDHLGEFVNSAEVARERTEECIQTIATIADQELNSHVSLKMTSLGL DIDMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKTLDIFKDFRKKYEHVSTVLQA YLYRTEKDIDDLDSLNPFLRLVKGAYKESEKVAFPEKSDVDENYKKIIRKQLLNGHYT AIATHDDKMIDFTKQLAKEHGIANDKFEFQMLYGMRSQTQLSLVKEGYNMRVYLPYGE DWYGYFMRRLAERPSNIAFAFKGMTKK*" /label="putB CDS" gene 326118..327029 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /label="putB gene" CDS 327046..328593 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 17183215, 21840319, 22139509, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 17183215, 21840319, 22139509, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-pyrroline-5-carboxylate dehydrogenase" /protein_id="NP_388203.2" /db_xref="EnsemblGenomes-Gn:BSU03210" /db_xref="EnsemblGenomes-Tr:CAB12115" /db_xref="GOA:P94391" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12012" /db_xref="UniProtKB/Swiss-Prot:P94391" /translation="MTTPYKHEPFTNFQDQNNVEAFKKALATVSEYLGKDYPLVINGE RVETEAKIVSINPADKEEVVGRVSKASQEHAEQAIQAAAKAFEEWRYTSPEERAAVLF RAAAKVRRRKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSR EGEKNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASATPVIAAKFV EVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSLITFTGSREVGTRIFERAAKVQPG QQHLKRVIAEMGGKDTVVVDEDADIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYD QVLERVIEITESKVTAKPDSADVYMGPVIDQGSYDKIMSYIEIGKQEGRLVSGGTGDD SKGYFIKPTIFADLDPKARLMQEEIFGPVVAFCKVSDFDEALEVANNTEYGLTGAVIT NNRKHIERAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQA KTISEMF*" /label="putC CDS" gene 327046..328593 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /label="putC gene" promotor_-35 328017..328023 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328037..328056 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328045 /Source="Nicolas_upshifts" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 328128..328134 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328147..328166 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328156 /Source="Nicolas_upshifts" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" misc_feature 328592..328596 /Source="Nicolas_upshift_promotors" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 328594..328716 /Source="Nicolas_S_feature" /locus_tag="new_347027_347149" /HighExp="S1, T2.0H, T2.30H, Lbstat, aero, HiOs, BC, Sw, LPh, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52312199999999998" /TUshortSig="Sig-, SigA, SigA, SigA, SigEF" /TUshortPSig="0.249, 1, 0.994, 0.922, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S116" upshifts 328596 /Source="Nicolas_upshifts" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 328717..330138 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline permease" /protein_id="NP_388204.2" /db_xref="EnsemblGenomes-Gn:BSU03220" /db_xref="EnsemblGenomes-Tr:CAB12116" /db_xref="GOA:P94392" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12013" /db_xref="UniProtKB/Swiss-Prot:P94392" /translation="MLLIGYFAYKRTSNLTDYMLGGRSLGPAVTALSAGAADMSGWLL MGLPGAMFSTGLSGAWIVIGLCLGAWANWLYVAPRLRTYTEKAGNSITIPGFLENRFG DQTKLLRLFSGIVILVFFTFYVSSGMVSGGVLFNSILGMDYHTGLWIVTGVVVAYTLF GGFLAVSWTDFVQGIIMFAALILVPIVTFFHTGGAGDTVAEIRSVDPDMFNIFKGTSV LGIISLFAWGLGYFGQPHIIVRFMAITSVKEIKRARRIGMGWMILSAVGAVLTGLGGI AYYHQRGMTLKDPETIFIQLGNILFHPIITGFLISAILAAIMSTISSQLLVTSSSLVE DLYKSMFRRSASDKELVFLGRLAVLAVSIVALVLAWEKNNTILGLVSYAWAGFGASFG PVVLLSLFWKRMTKWGALAGMIVGAATVIIWANAGLSDFLYEMIPGFAASLLSVFFVS ILTQAPSQAVTDQFNDYQDTMSQ*" /label="putP CDS" gene 328717..330138 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /label="putP gene" S_feature complement(329237..331092) /Source="Nicolas_S_feature" /locus_tag="new_347670_349525_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, C30, T4.0H, Lbstat" /AntisenseName="ycgP" /AntisenseCor="0.143781082577395" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.679" /TUlongSig="NA" /TUlongPSig="NA" /label="S117" downshifts 330118 /Source="Nicolas_upshifts" /id="D142" /incds=0 /nref=21 /ntot=160 /MaxReadThrough="5.09597" /MaxDrop="4.17771" /score="5.89792272" /energy="-15.9" /TU="U239,U240,U242" /idTUdmin="U238" /TUdmin=4 /isTUend="TRUE" /label="downshifts" S_feature 330163..330259 /Source="Nicolas_S_feature" /locus_tag="new_348596_348692" /HighExp="S1, LPh, T2.0H, HPh, aero, Lbstat, LoTm, T2.30H, Cold, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.249, 0.994, 0.922" /TUlongSig="NA" /TUlongPSig="NA" /label="S118" promotor_-35 330230..330237 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 330252..330271 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 330261 /Source="Nicolas_upshifts" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 330291..331526 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21840319, 21964733, 22139509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21840319, 21964733, 22139509; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of proline degradationoperon" /protein_id="NP_388205.2" /db_xref="EnsemblGenomes-Gn:BSU03230" /db_xref="EnsemblGenomes-Tr:CAB12117" /db_xref="GOA:P94393" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12014" /db_xref="UniProtKB/Swiss-Prot:P94393" /translation="MEELLERVFSFSDVDKLIDFISYELQKPVILESADFFLLAYNSY YINHFDSANQQTIFSKKCPVQIFERFLKDGIIEKLKTEPEPFRVNKIESIGLNQRVVV SAKHKGEVMGYIWIQELDQNLTDEELDFLYETSFHVGKIIYKTNKLKQEKEEKAEDLI KRAIYQQFTSEKELRREAERINTVLPSMFSVVILHAANGDGEAVEDLKENIRSYLNLR DKVSHVLTIESNIVIVVASFSQKSSVSSAASEFINKLLTHFHFQKIPTPIYIGIGNEY NHLLKLGKSYTEALEVIKAAEITGNQENIPYEYAKLGIYRYLESIEQKNEFLEYENKD LALLKAKDEESSTELLKTLEIYLLNNCKTKPAAEQLFIHQNTLNYRIKQITEMTSIDL SDFRTRCQLYLDLMLMKKK*" /label="putR CDS" gene 330291..331526 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /label="putR gene" promotor_-10 complement(331085..331103) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(331102) /Source="Nicolas_upshifts" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(331117..331124) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(331510) /Source="Nicolas_upshifts" /id="D143" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="0.0291099999999993" /MaxDrop="3.08474" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=66 /isTUend="FALSE" /label="downshifts" CDS complement(331563..332420) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388206.1" /db_xref="EnsemblGenomes-Gn:BSU03240" /db_xref="EnsemblGenomes-Tr:CAB12118" /db_xref="GOA:P94394" /db_xref="InterPro:IPR015402" /db_xref="SubtiList:BG12015" /db_xref="UniProtKB/Swiss-Prot:P94394" /translation="MFRLLVLMGFTFFFYHLHASGNLTKYINMKYAYLSFIAIFLLAI LTAVQAYLFIKSPEKSGHHHDHDCGCGHDHEHDHEQNKPFYQRYLIYVVFLFPLVSGI FFPIATLDSSIVKTKGFSFKAMESGDHYSQTQYLRPDASLYYAQDSYDKQMKQLFNKY SSKKEISLTDDDFLKGMETIYNYPGEFLGRTIEFHGFAYKGNAINKNQLFVLRFGIIH CIADSGVYGMLVEFPKDMDIKDDEWIHIKGTLASEYYQPFKSTLPVVKVTDWNTIKKP DDPYVYRGF*" /label="ycgQ CDS" gene complement(331563..332420) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /label="ycgQ gene" downshifts complement(331576) /Source="Nicolas_upshifts" /id="D144" /incds=0 /nref=48 /ntot=167 /MaxReadThrough="1.97725" /MaxDrop="4.53007" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(332425..333309) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388207.1" /db_xref="EnsemblGenomes-Gn:BSU03250" /db_xref="EnsemblGenomes-Tr:CAB12119" /db_xref="GOA:P94395" /db_xref="InterPro:IPR005524" /db_xref="SubtiList:BG12016" /db_xref="UniProtKB/Swiss-Prot:P94395" /translation="MTAQSSFLQLNSIFISILIEAIPFILIGVILSGIIQMFVSEEMI ARIMPKNRFLAVLFGALAGVLFPACECGIIPITRRLLLKGVPLHAGVAFMLTAPIINP IVLFSTYIAFGNRWSVVFYRGGLALAVSLIIGVILSYQFKDNQLLKPDEPGHHHHHHG TLLQKLGGTLRHAIDEFFSVGKYLIIGAFIAAAMQTYVKTSTLLAIGQNDVSSSLVMM GLAFVLSLCSEVDAFIASSFSSTFSLGSLIAFLVFGAMVDIKNLLMMLAAFKKRFVFL LITYIVVIVLAGSLLVKG*" /label="ycgR CDS" gene complement(332425..333309) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /label="ycgR gene" upshifts complement(333361) /Source="Nicolas_upshifts" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(333366..333379) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(333394..333402) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(333409..334263) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /EC_number="3.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic hydrocarbon hydrolase" /protein_id="NP_388208.1" /db_xref="EnsemblGenomes-Gn:BSU03260" /db_xref="EnsemblGenomes-Tr:CAB12120" /db_xref="GOA:P94396" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12017" /db_xref="UniProtKB/Swiss-Prot:P94396" /translation="MKRRVETITFDGGTLEYSVTGKGTPILVMHGGHSNCYEEFGYTA LIEQGYSIITPSRPGYGRTSKEIGKSLANACRFYVKLLDHLQIESVHVIAISAGGPSG ICFASHYPERVNTLTLQSAVTKEWLTPKDTEYKLGEILFRPPVEKWIWKLISSLNNAF PRLMFRAMSPQFSTLPFQRIKSLMNEKDIEAFRKMNSRQRSGEGFLIDLSQTAAVSLK DLQAIICPVLIMQSVYDGLVDLSHAHHAKEHIRGAVLCLLHSWGHLIWLGKEAAETGS ILLGFLES*" /label="ycgS CDS" gene complement(333409..334263) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /label="ycgS gene" promotor_-10 complement(334282..334301) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-10" upshifts complement(334302) /Source="Nicolas_upshifts" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="upshifts" promotor_-35 complement(334316..334319) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-35" misc_feature 334353..334372 /Source="Nicolas_upshift_promotors" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(334353..334371) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 334360..334424 /Source="Nicolas_S_feature" /locus_tag="new_352793_352857" /HighExp="B60, Lbexp, LBGexp, dia0, B36, HiOs, GM 15, GM 10, Salt, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S119" upshifts 334361 /Source="Nicolas_upshifts" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(334370) /Source="Nicolas_upshifts" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(334387..334392) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 334425..335435 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /EC_number="1.18.1.-" /EC_number="1.8.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16672620, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 25826316; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Fur-regulated NADPH:ferredoxin oxidoreductase" /protein_id="NP_388209.1" /db_xref="EnsemblGenomes-Gn:BSU03270" /db_xref="EnsemblGenomes-Tr:CAB12121" /db_xref="GOA:O31475" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12018" /db_xref="UniProtKB/Swiss-Prot:O31475" /translation="MAENQEVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGG KVSLFFPEKIIRDIGGIPGIAGKQLIEQLKEQAATFDPDIVLNQRVTGFERLDDGTIV LTGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVI SGGGDTAVDWANELEPIAASVTVVHRREEFGGMESSVTKMKQSSVRVLTPYRLEQLNG DEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPMMEWGLEIEEGRVKADRHMR TNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPKAENMAMYSTHHKKLV HK*" /label="ffoR CDS" gene 334425..335435 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /label="ffoR gene" S_feature 335436..337883 /Source="Nicolas_S_feature" /locus_tag="new_353869_356316" /HighExp="B60, Lbexp, GM 10, GM 25, HiOs, GM 15, dia0, GM 45, LBGexp, H2O2" /AntisenseName="nasF" /AntisenseCor="-0.30348565853404702" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S120" CDS complement(335467..336918) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /EC_number="2.1.1.107" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9765565, 10217486, 15028686" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765565, 10217486, 15028686; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrin-III C-methyltransferase" /protein_id="NP_388210.1" /db_xref="EnsemblGenomes-Gn:BSU03280" /db_xref="EnsemblGenomes-Tr:CAB12122" /db_xref="GOA:P42437" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR012409" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG11098" /db_xref="UniProtKB/Swiss-Prot:P42437" /translation="MIMKNGIVYFVGAGPGDPGLLTIKGKQALKEADVILYDRLANPK LLEFASPDCQFIYCGKLPNRHFMKQKEINALLVEKALNGLTVVRLKGGDPSVFGRVGE EADALHEHGIRYEMVPGITSGIAAPLYAGIPVTHRDFASSFAMITAHDKSLKGTPNLD WEGLARSVQTLVFYMGVKNLSYICQQLISYGKSPSVPVIVIQWGTWGRQRSVKGTLEN IQQKVQEHQITNPAIIVIGDIVNFQTHSWFESKPLIGRHLMVVTHGEDEDPLADKLRD SGADLIEWPKWRTENMPVNEEILRKIGTFEDVFFTSRRAVCEFFRALASQKIDIRQLT AKLSAASEQAKTELEKRGFLVTAIQPDSEKRLVVGSRHAVENMQKHESCSFYITHENV IDDRFTHMIQRTISESPLHMVICPNKLSVQQLINGGEQIGILPEPSASRPPIVCIGDD SAAGIYGFTAVQEQDELLAFIHNQHAEKKLLHT*" /label="nasF CDS" gene complement(335467..336918) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /label="nasF gene" downshifts complement(335471) /Source="Nicolas_upshifts" /id="D145" /incds=0 /nref=131 /ntot=230 /MaxReadThrough="1.40657" /MaxDrop="6.58881" /score="10.9556399" /energy="-11.7" /TU="NA" /idTUdmin="U250" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(336979..337299) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 15028686, 9765565, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 15028686, 9765565, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388211.1" /db_xref="EnsemblGenomes-Gn:BSU03290" /db_xref="EnsemblGenomes-Tr:CAB12123" /db_xref="GOA:P42436" /db_xref="InterPro:IPR012748" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11097" /db_xref="UniProtKB/Swiss-Prot:P42436" /translation="MVNKDVTKVCIGKIEELPEQLGKTVYIEDKELAVFKLSDGSIRA IENRCPHKGGVLAEGIVSGQYVFCPMHDWKISLEDGIVQEPDHGCVKTYETLIEGEHV YLVY*" /label="nasE CDS" gene complement(336979..337299) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /label="nasE gene" promotor_-35 337150..337155 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 337169..337173 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 337176 /Source="Nicolas_upshifts" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(337208) /Source="Nicolas_upshifts" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(337210..337229) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(337243..337250) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(337331..339748) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565, 16428414, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565, 16428414, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388212.1" /db_xref="EnsemblGenomes-Gn:BSU03300" /db_xref="EnsemblGenomes-Tr:CAB12124" /db_xref="GOA:P42435" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11096" /db_xref="UniProtKB/Swiss-Prot:P42435" /translation="MGKKQLVLVGNGMAGVRAIEEILSVAKDEFQITIFGAEPHPNYN RILLSKVLQGDTDIKDITLNDWDWYEENNIQLYTNETVIKVDTENKTVITDADRIQPY DELILATGSVPFILPIPGADKKGVTAFRDIKDTDTMLAASKQYKKAAVIGGGLLGLEA ARGLLNLGMDVSVIHLAPFLMERQLDATAGRLLQNELEKQGMTFLLEKQTEEIVGDDR VEGLRFKDGTSIEADLVVMAVGIRPNTTLGAESGIPVNRGIIVNDYMQTEIPHIYAVG ECAEHRGIAYGLVAPLYEQAKVLAKHMCGIETKPYEGSVLSTQLKVSGVEVFSAGDFN ESEEKKAIKVFDEQDGIYKKIVLRGNQIVGAVLFGDSSEGNRLFSMIQKEADISETSK ISILQPLSQEAGTSITAAMSDDEIICGCNGVSKGAIIQAIQEKGCSSTDEIKACTGAS RSCGGCKPLVEEILQHTLGSDFDASAQKEAICGCTTLSRDEVVEEIKAKGLSHTREVM NVLGWKTPEGCSKCRPALNYYLGMINPTKYEDDRTSRFVNERMHANIQKDGTYSVVPR MYGGVTNSTDLRKIADVVDKYEIPLVKMTGGQRIDLIGVKKEDLPKVWEDLDMPSGYA YGKTLRTVKTCVGEQFCRFGTQDSMALGIALEKKFEGLNTPHKVKMAVSACPRNCAES GIKDLGVVGIDGGWELYVGGNGGTHLRAGDLLMKVKTNEEVLEYAGAYLQYYRETANY LERTSAWLERVGLSHVQSVLNDPEKRQELNGRMNETLSVHKDPWKDFLEDKQTSKELF ENVVTTS*" /label="nasD CDS" gene complement(337331..339748) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /label="nasD gene" promotor_-10 complement(339773..339792) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(339787) /Source="Nicolas_upshifts" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(339804..339810) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(339870..342002) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /EC_number="1.7.99.4" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (catalytic subunit)" /protein_id="NP_388213.2" /db_xref="EnsemblGenomes-Gn:BSU03310" /db_xref="EnsemblGenomes-Tr:CAB12125" /db_xref="GOA:P42434" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="SubtiList:BG11095" /db_xref="UniProtKB/Swiss-Prot:P42434" /translation="MTERLLRYFRDKQQDVQSEKTYDTQCPFCSMQCKMQLVEQTIVT RKKYTAIGIDNPTTQGRLCIKGMNAHQHALNSSRITRPLLKKNGEFMPVSWEEALNHI KDQVTMIQTEHGHDAMAVYGSASITNEEAYLLGKFARVGLQTKYIDYNGRLCMSAAAT AANQTFGADRGLTNPLSDIPHTRVIILAGTNIAECQPTIMPYFEKAKENGAYFIAIDP RETATTKIADLHLKIKPGTDAALANGLVKIIIDEQLINEDFIQSRTNGFEELKQHTDS LDLNDIAEQTSVSLVDIRKAAVKFAKETSGMLFTARGIEQQTDGTAAVKGFLNMVLIT GKIGKPYSGYGAITGQGNGQGAREHGQKADQLPGYRSIENEEHRAHIAKVWGIHQDEL PRKGVSAYEMMEKINDGDIKGLFLMCSNPAVSSPNANLVKKALRRLTFFVAIDLFISE TAKYADVILPASSYLEDEGTMTNVEGRVTLREASRPCPGEAKHDWQIICDLASALGKG RYFSYTSAEDIFNELREASRGGIADYSGISYGRLRREGGIHWPCPESDHPGTGRLFTE SFAHPDQKAALSVIPNEPPVPKEKPTADYPLYLTTGRVMSHYLTGVQTRKSAALAARH FESFMEIHPQTAATYNIEDRVLVKIESPRGSITVRSKLSEQIRKDTVFVPIHWADAQN VNDLIGEALDPACKMPGFKVCAVRIIPI*" /label="nasC CDS" gene complement(339870..342002) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /label="nasC gene" CDS complement(342009..344324) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /EC_number="1.7.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (electron transfer subunit NasB)" /protein_id="NP_388214.2" /db_xref="EnsemblGenomes-Gn:BSU03320" /db_xref="EnsemblGenomes-Tr:CAB12126" /db_xref="GOA:P42433" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11094" /db_xref="UniProtKB/Swiss-Prot:P42433" /translation="MKKQRLVLAGNGMAGIRCIEEVLKLNRHMFEIVIFGSEPHPNYN RILLSSVLQGEASLDDITLNSKDWYDKHGITLYTGETVIQIDTDQQQVITDRKRTLSY DKLIVATGSSPHILPIPGADKKGVYGFRTIEDCQALMNMAQHFQKAAVIGAGLLGLEA AVGLQHLGMDVSVIHHSAGIMQKQLDQTAARLLQTELEQKGLTFLLEKDTVSISGATK ADRIHFKDGSSLKADLIVMAAGVKPNIELAVSAGIKVNRGIIVNDFMQTSEPNIYAVG ECAEHNGTVYGLVAPLYEQGKALASHICGVPCEEYQGSAPSAALKIAGIDVWSAGKIQ EDERTTSIKIYDEQAGVYKKALFVDDKLAGVILFGDTRDKQRLLDSLLKQRDISIAKK QIIEPETSGPLFESMPSSETICQCNTVTKGAIEDAVHTNSLTTVEEVKHCTKATGSCG GCKPLVEDLLRYMTNSEYTKPASTPSFCSCTDFTEDDIIAELQRRPFTNPAEVMNQLD WKTKNGCSTCVPAIQYYLEMLYPGFVQPEPATEETCILIPQMYGGRTNAEQLRTIANI IEAYSIPDVSITHGQRLKLSGIKPADLPNMKKDLKMPVYTNEHRHALQSIKACTCGQN RSIQQLAAQIERQLEMLPLPAPISISLSCETDCTEAALQDVGAIRTQAGWDIHIGGVR GTHARSGALFCVTENEDSTAGMIKGLIQYYRETAHYLEGVHQWIDRLGIVHIREVLFE EDLRAQLLESLQTDLSLIQNPTVETGAYKKG*" /label="nasB CDS" gene complement(342009..344324) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /label="nasB gene" promotor_no_box complement(344343..344443) /Source="Nicolas_upshift_promotors" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(344383) /Source="Nicolas_upshifts" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 344426..344433 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 344447..344466 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 344459 /Source="Nicolas_upshifts" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="upshifts" CDS 344504..345709 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7868621, 12823818, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative nitrate transporter" /protein_id="NP_388215.2" /db_xref="EnsemblGenomes-Gn:BSU03330" /db_xref="EnsemblGenomes-Tr:CAB12127" /db_xref="GOA:P42432" /db_xref="InterPro:IPR004737" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11093" /db_xref="UniProtKB/Swiss-Prot:P42432" /translation="MKLSELKTSGHPLTLLCSFLYFDVSFMIWVMLGALGVYISQDFG LSPFEKGLVVAVPILSGSVFRIILGILTDRIGPKKTAVIGMLVTMIPLLWGTFGGRSL TELYAIGILLGVAGASFAVALPMASRWYPPHLQGLAMGIAGAGNSGTLFATLFGPRLA EQFGWHIVMGIALIPLLIVFILFVSMAKDSPAQPSPQPLKSYLHVFGQKETWFFCLLY SVTFGGFVGLSSFLSIFFVDQYQLSKIHAGDFVTLCVAAGSFFRPVGGLISDRVGGTK VLSVLFVIVALCMAGVSSLPSLSMVIVLLFVGMMGLGMGNGAVFQLVPQRFRKEIGMV TGIVGAAGGIGGFFLPNILGSLKQMTGTYAIGFITFSCIALLAFALVLAAGYYWRKSW SAESSPADV*" /label="nasA CDS" gene 344504..345709 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /label="nasA gene" downshifts 345694 /Source="Nicolas_upshifts" /id="D146" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.02479" /MaxDrop="3.6823" /score="39.2612286" /energy="-11.9" /TU="NA" /idTUdmin="U253" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 345753..345759 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-35" promotor_-10 345774..345793 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-10" upshifts 345782 /Source="Nicolas_upshifts" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="upshifts" CDS 345826..346740 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12426338, 17032654, 19767425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12426338, 17032654, 19767425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_388216.2" /db_xref="EnsemblGenomes-Gn:BSU03340" /db_xref="EnsemblGenomes-Tr:CAB12128" /db_xref="GOA:P94398" /db_xref="InterPro:IPR003801" /db_xref="InterPro:IPR022838" /db_xref="SubtiList:BG12019" /db_xref="UniProtKB/Swiss-Prot:P94398" /translation="MNQHTLLPKKTERLQYFGSVSPIKGEKPVEKEKMKDLQNIRKDY FFDIQHVGVANVSHPVTITSAMMPAEQTTAANFTMTCNLPRNQKGINMSRLTELLQVY HQNGWILSFSSLQQFTKELAENMDTSSATVEVRFPWFFERKSPKLEKAGLMHADIFMS VTYRKDQPFKQRAGISAKVTTLCPCSKEISEYSAHNQRGTVSIWADIHPAASLPSDVK ADLLHAAESNASARLHPVLKRPDEKAVTETAYENPRFVEDLARLIAADLFELEWVSAF EIECRNEESIHLHDAYAKLCFSKEVDKI*" /label="folEB CDS" gene 345826..346740 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /label="folEB gene" CDS 346737..347321 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12426338, 20013255; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative Zn(2+)-dependent division lipoprotein (schizosome)" /protein_id="NP_388217.2" /db_xref="EnsemblGenomes-Gn:BSU03350" /db_xref="EnsemblGenomes-Tr:CAB12129" /db_xref="GOA:C0SP99" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG12020" /db_xref="UniProtKB/Swiss-Prot:C0SP99" /translation="MKLSLFIIAVLMPVILLSACSDHAEEHASINTKKTVENITDVRK TAKTSIDWTKPSGGEYPDIKQKHVWIDVNVKEQKAYIKEGSNTIYTMMISSGLDQTKD DATPKGTFYVEPERGEWFFSEGYQEGAEYWVSWKNHGEFLFHSVPMTKDQKVIKTEAE KLGTKASHGCIRLTIPDAKWVYENIPEHTKVVIS*" /label="yciB CDS" gene 346737..347321 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /label="yciB gene" promotor_-35 347332..347339 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 347353..347372 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 347363 /Source="Nicolas_upshifts" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="upshifts" CDS 347417..347602 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097674.1" /db_xref="EnsemblGenomes-Gn:BSU03359" /db_xref="EnsemblGenomes-Tr:CAX52544" /db_xref="UniProtKB/Swiss-Prot:C0H3U7" /translation="MKSGKASIKDLAVGKGKDLRWGKGLNAVGVFTDLEIGRQREMSA KSCSTPLYIRRSIQFKS*" /label="yczL CDS" gene 347417..347602 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /label="yczL gene" CDS 347630..348823 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249; Product type t: transporter" /codon_start=1 /transl_table=11 /product="zinc metallochaperone with NTPase activity" /protein_id="NP_388218.1" /db_xref="EnsemblGenomes-Gn:BSU03360" /db_xref="EnsemblGenomes-Tr:CAB12130" /db_xref="GOA:P94400" /db_xref="InterPro:IPR003495" /db_xref="InterPro:IPR011629" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036627" /db_xref="SubtiList:BG12021" /db_xref="UniProtKB/Swiss-Prot:P94400" /translation="MKKIPVTVLSGYLGAGKTTLLNSILQNREGLKIAVIVNDMSEVN IDAGLVKQEGGLSRTDEKLVEMSNGCICCTLREDLLIEVEKLAKDGRFDYIVIESTGI SEPIPVAQTFSYIDEEMGIDLTKFCQLDTMVTVVDANRFWHDYQSGESLLDRKEALGE KDEREIADLLIDQIEFCDVLILNKCDLVSEQELEQLENVLRKLQPRARFIRSVKGNVK PQEILHTGLFNFEEASGSAGWIQELTAGHAEHTPETEEYGISSFVYKRRLPFHSTRFY RWLDQMPKNVVRAKGIVWCASHNNLALLMSQAGPSVTIEPVSYWVAALPKLEQEQVKQ QEPEILEEWDPEFGDRLTQLVFIGTDLDEETITKELDQCLLTEYEFDSDWSLFEDPFK WKLNQ*" /label="zinU CDS" gene 347630..348823 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /label="zinU gene" downshifts 348815 /Source="Nicolas_upshifts" /id="D147" /incds=0 /nref=26 /ntot=45 /MaxReadThrough="5.12378" /MaxDrop="5.8275" /score="15.6427627" /energy="-9.2" /TU="U255" /idTUdmin="U255" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" S_feature 348860..350529 /Source="Nicolas_S_feature" /locus_tag="new_367293_368962" /HighExp="Etha, B60, Cold, Heat, B36, C30, BMM, S6, C90, S2" /AntisenseName="yckB" /AntisenseCor="-0.170121935628575" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S121" CDS complement(348872..349552) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aminoacid ABC transporter (permease subunit)" /protein_id="NP_388219.1" /db_xref="EnsemblGenomes-Gn:BSU03370" /db_xref="EnsemblGenomes-Tr:CAB12131" /db_xref="GOA:P42399" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11177" /db_xref="UniProtKB/Swiss-Prot:P42399" /translation="MINSIQWEYIFNTKLAIESFPYVIKGIGYTLLISFVSMFAGTVI GLFISLARMSKLALLRWPAKLYISFMRGVPILVILFILYFGFPYIGIEFSAVTAALIG FSLNSAAYIAEINRSAISSVEKGQWEAASSLGLSYWQTMRGIILPQSIRIALPPLANV LLDLIKASSLAAMITVPELLQHAKIIGGREFDYMTMYILTALIYWAICSIAAVFQNIL EKKYAHYV*" /label="yckA CDS" gene complement(348872..349552) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /label="yckA gene" downshifts complement(348878) /Source="Nicolas_upshifts" /id="D148" /incds=0 /nref=101 /ntot=231 /MaxReadThrough="0.41655" /MaxDrop="6.18136" /score="40.1548023" /energy="-12.6" /TU="NA" /idTUdmin="U256" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(349562..350425) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23038252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="amino acid ABC transporter (binding lipoprotein subunit)" /protein_id="NP_388220.1" /db_xref="EnsemblGenomes-Gn:BSU03380" /db_xref="EnsemblGenomes-Tr:CAB12132" /db_xref="GOA:P42400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="PDB:2IEE" /db_xref="SubtiList:BG11178" /db_xref="UniProtKB/Swiss-Prot:P42400" /translation="MKSFMHSKAVIFSFTMAFFLILAACSGKNEADSKDTGWEQIKDK GKIVVATSGTLYPTSYHDTDSGSDKLTGYEVEVVREAAKRLGLKVEFKEMGIDGMLTA VNSGQVDAAANDIDVTKDREEKFAFSTPYKYSYGTAIVRKDDLSGIKTLKDLKGKKAA GAATTVYMEVARKYGAKEVIYDNATNEQYLKDVANGRTDVILNDYYLQTLALAAFPDL NITIHPDIKYMPNKQALVMKKSNAALQKKMNEALKEMSKDGSLTKLSKQFFNKADVSK KIDADVQDVDL*" /label="yckB CDS" gene complement(349562..350425) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /label="yckB gene" promotor_-10 complement(350447..350466) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(350459) /Source="Nicolas_upshifts" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(350461..353295) /Source="Nicolas_S_feature" /locus_tag="new_368894_371728_c" /HighExp="GM 150, T-4.40H, G/S, Pyr, S2, C30, T-5.40H, C90, T-3.40H, T0.30H" /AntisenseName="bglC" /AntisenseCor="-0.37749573319969598" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, Sig-" /TUshortPSig="0.248, 0.994, 0.0879" /TUlongSig="SigD" /TUlongPSig=1 /label="S122" promotor_-35 complement(350481..350488) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 350498..350504 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350519..350537 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 350531..350753 /Source="Nicolas_S_feature" /locus_tag="new_368964_369186" /HighExp="Etha, Salt, B60, Sw, B36, Gly, Heat, S6, Cold, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99896700000000005" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S123" upshifts 350531 /Source="Nicolas_upshifts" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 350587..350784 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513942.1" /translation="MSKDECQTYQGNACESEGCSRPVTHLCQYRKKWSRGMKPIFRIN LSLADAPKAYDIFDEKENGNI*" /label="hypothetical protein CDS" gene 350587..350784 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /label="gene" promotor_-35 350722..350727 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350743..350761 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 350755 /Source="Nicolas_upshifts" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 350803..351258 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral membrane protein of unknown function" /protein_id="NP_388221.1" /db_xref="EnsemblGenomes-Gn:BSU03390" /db_xref="EnsemblGenomes-Tr:CAB12133" /db_xref="GOA:P42401" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11179" /db_xref="UniProtKB/Swiss-Prot:P42401" /translation="MNIYKPAGFWIRLGAALLDYIIVSVPLLLIYWLITGKDPNDSMF ISLVVLLYSILLPMFWRGYLIGKRICGIRIVKKDGSQVSLLTMFLRVIVAGLVYCITF GLGLIASLILIAVREDKRTLHDLIAGTYVTYATPGEEELNADEEIRKSE*" /label="yckC CDS" gene 350803..351258 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /label="yckC gene" downshifts 351233 /Source="Nicolas_upshifts" /id="D149" /incds=0 /nref=40 /ntot=193 /MaxReadThrough="1.14817" /MaxDrop="5.48303" /score="23.1539807" /energy="-9.8" /TU="NA" /idTUdmin="U257" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 351281..351287 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 351294 /Source="Nicolas_upshifts" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 351301..351312 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 351340..351672 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388222.1" /db_xref="EnsemblGenomes-Gn:BSU03400" /db_xref="EnsemblGenomes-Tr:CAB12134" /db_xref="InterPro:IPR024485" /db_xref="SubtiList:BG11180" /db_xref="UniProtKB/Swiss-Prot:P42402" /translation="MKRITINIITMFIAAAVISLTGTAEAAEKQQQSPANVTLTDQQK KEIEQLEAEILKKRKDVISKYVQYGILPKERGEHIKNHLDKHFEMMKQNGFVPKHHPH PHKFEKRH*" /label="yckD CDS" gene 351340..351672 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /label="yckD gene" downshifts 351653 /Source="Nicolas_upshifts" /id="D150" /incds=0 /nref=20 /ntot=44 /MaxReadThrough="2.48743" /MaxDrop="4.3022" /score="-1.40416926" /energy="-11.8" /TU="NA" /idTUdmin="U259" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 351758..351765 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 351781..351800 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 351785 /Source="Nicolas_upshifts" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="upshifts" CDS 351826..353259 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18069788" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18069788; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_388223.1" /db_xref="EnsemblGenomes-Gn:BSU03410" /db_xref="EnsemblGenomes-Tr:CAB12135" /db_xref="GOA:P42403" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11181" /db_xref="UniProtKB/Swiss-Prot:P42403" /translation="MIHQHPESFPKHFLWGSASAAYQIEGAWNEDGKGPSVWDVFTKI PGKTFKGTNGEIAVDHYHRFKEDVALMAEMGLKAYRFSVSWPRVFPKGKGEINEAGLA FYDSLIDELLSHHIEPVLTLYHWDLPQALMDEYGGFESRNIIEDFNHYCITLYKRFGD RVKYWVTLNEQNYNFNHGFITAMHPPGVKDRKRFYEANHIAFLANAKAIESFREYVPE GKIGPSFAYSPAYPLSSHPEDILAFENAEEFTNNWWLDMYCWGTYPQIPFRCLEKQGW APTIEAGDMDLLAKGKPDFVGVNYYQTITYERNPLDGVSEGKMNTTGQKGTNQETGIP GVFKTKKNPHLTTSNWDWTIDPIGLRIGLRRITSRYQLPVFITENGLGEFDKVEDGTV QDDYRIDYLRSHLEQCRQAISDGVDLIGYCSWSFTDLLSWLNGYQKRYGFVYVNRDEE STSDLKRLKKKSFYWYQDVIKTNGESL*" /label="bglC CDS" gene 351826..353259 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /label="bglC gene" downshifts 353237 /Source="Nicolas_upshifts" /id="D151" /incds=0 /nref=12 /ntot=61 /MaxReadThrough="1.51167" /MaxDrop="4.6748" /score="18.0928088" /energy="-15.9" /TU="NA" /idTUdmin="U260" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(353296..353694) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11359569, 11814663, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11359569, 11814663, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the DNA degrading activity of NucA (competence)" /protein_id="NP_388224.1" /db_xref="EnsemblGenomes-Gn:BSU03420" /db_xref="EnsemblGenomes-Tr:CAB12136" /db_xref="GOA:P12669" /db_xref="InterPro:IPR020354" /db_xref="PDB:4MQD" /db_xref="SubtiList:BG10839" /db_xref="UniProtKB/Swiss-Prot:P12669" /translation="MIKSWKPQELSISYHQFTVFQKDSTPPVMDWTDEAIEKGYAAAD GAISFEAQRNTKAFILFRLNSSETVNSYEKKVTVPFHVTENGIHIESIMSKRLSFDLP KGDYQLTCWTVPAEMSDLHADTYIIDAVSV*" /label="nin CDS" gene complement(353296..353694) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /label="nin gene" promotor_no_box complement(353691..353791) /Source="Nicolas_upshift_promotors" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="promotor_no_box" CDS complement(353721..354170) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2841296, 7746143, 11359569, 11814663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2841296, 7746143, 11359569, 11814663; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease" /protein_id="NP_388225.3" /db_xref="EnsemblGenomes-Gn:BSU03430" /db_xref="EnsemblGenomes-Tr:CAB12137" /db_xref="GOA:P12667" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG10838" /db_xref="UniProtKB/Swiss-Prot:P12667" /translation="MNITTDIIKTILLVIVIIAAAAVGLIKGDFFSADQKTSQTKEYD ETMAFPSDRYPETAKHIKDAINEGHSEVCTIDRDGAEERREQSLKDVPSKKGYDRDEW PMAMCKEGGEGASVEYISPADNRGAGSWVGHRLTDYPDGTKVLFTIQ*" /label="nucA CDS" gene complement(353721..354170) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /label="nucA gene" upshifts complement(353731) /Source="Nicolas_upshifts" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(354185..354204) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(354193) /Source="Nicolas_upshifts" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(354195..354337) /Source="Nicolas_S_feature" /locus_tag="new_372628_372770_c" /HighExp="C30, Diami, M40t45, Cold, Lbstat, T0.30H, M0t90, dia15, C90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD" /TUshortPSig="0.0879, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S124" promotor_-35 complement(354218..354225) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(354338..356059) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7704255, 7921238, 15187186, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704255, 7921238, 15187186, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (plant colonization)" /protein_id="NP_388226.2" /db_xref="EnsemblGenomes-Gn:BSU03440" /db_xref="EnsemblGenomes-Tr:CAB12138" /db_xref="GOA:P39209" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="SubtiList:BG10790" /db_xref="UniProtKB/Swiss-Prot:P39209" /translation="MLIKRFKMKLGTKILCLVFVVILLFSASVGTVMLKEITESMKQM ATEKAKGDLALSSTYIDDVMSGDWQVKNNKLYKGQTQINGNEDIVDLLGEKTGDTITI FQGDTRVATNVMKNGERAVGTQASSEVIAAVLKKGKRFYGQADVAGSSYQTAYMPLKD QNGNIIGMLYTGANQSILASLTQSLFTQFAIVLVIVIMVSVILVLVFTRKINKRLNAL KSAFESAGNGDMTIEVSDKTGDELSELSVYYNKMRMKLNDTIQTVQQSALQLASASQQ LSAGAEETNQASEKITEAVQQIANGAQDQITRIENSESSLKQASADIRDISANTAAIA DKGQLAQSKADIGQKEIANVQAQMDAIHQSIQKSGEIIHQLDGRSKQIEQILSVITQI ADQTNLLALNAAIEAARAGEQGKGFAVVADEVRKLAEESQQSAGQISKLIIEIQKDMN RSARSVEHVKTEAAEGVTMIQRTRDAFKEIAAATGEISAEISDLSASVTNISASAHQI NDSFAANTADIKESTKNTRQAAALTEEQFAAMEEITAASETLSQLAEELTGIISQFKM INQAENG*" /label="tlpC CDS" gene complement(354338..356059) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /label="tlpC gene" promotor_-35 354350..354357 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 354368..357511 /Source="Nicolas_S_feature" /locus_tag="new_372801_375944" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, T4.0H, T0.0H, T-0.40H" /AntisenseName="tlpC" /AntisenseCor="-0.40398083053643302" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S125" upshifts 354368 /Source="Nicolas_upshifts" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 354372..354391 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box complement(354373..354473) /Source="Nicolas_upshift_promotors" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="promotor_no_box" upshifts complement(354413) /Source="Nicolas_upshifts" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="upshifts" promotor_-10 complement(356083..356101) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-10" upshifts complement(356098) /Source="Nicolas_upshifts" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="upshifts" promotor_-35 complement(356115..356122) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-35" CDS complement(356170..356727) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /EC_number="5.3.1.27" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-3-hexuloisomerase (PHI)" /protein_id="NP_388227.1" /db_xref="EnsemblGenomes-Gn:BSU03450" /db_xref="EnsemblGenomes-Tr:CAB12139" /db_xref="GOA:P42404" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR017552" /db_xref="PDB:1M3S" /db_xref="PDB:1VIV" /db_xref="SubtiList:BG11182" /db_xref="UniProtKB/Swiss-Prot:P42404" /translation="MKTTEYVAEILNELHNSAAYISNEEADQLADHILSSHQIFTAGA GRSGLMAKSFAMRLMHMGFNAHIVGEILTPPLAEGDLVIIGSGSGETKSLIHTAAKAK SLHGIVAALTINPESSIGKQADLIIRMPGSPKDQSNGSYKTIQPMGSLFEQTLLLFYD AVILKLMEKKGLDSETMFTHHANLE*" /label="hxlB CDS" gene complement(356170..356727) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /label="hxlB gene" downshifts complement(356173) /Source="Nicolas_upshifts" /id="D152" /incds=0 /nref=51 /ntot=130 /MaxReadThrough="1.98332" /MaxDrop="6.56052" /score="42.3682356" /energy="-15.4" /TU="NA" /idTUdmin="U266" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(356733..357365) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /EC_number="4.1.2.43" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hexulose-6-phosphate synthase (HPS)" /protein_id="NP_388228.1" /db_xref="EnsemblGenomes-Gn:BSU03460" /db_xref="EnsemblGenomes-Tr:CAB12140" /db_xref="GOA:P42405" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017553" /db_xref="SubtiList:BG11183" /db_xref="UniProtKB/Swiss-Prot:P42405" /translation="MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAV KEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADIITVLGATDDATIKGAVEEAKKQ KKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNA KTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG*" /label="hxlA CDS" gene complement(356733..357365) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /label="hxlA gene" promotor_-10 complement(357391..357410) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(357406) /Source="Nicolas_upshifts" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(357425..357428) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 357489..357492 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 357507..357526 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 357513 /Source="Nicolas_upshifts" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="upshifts" CDS 357599..357961 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15978081, 26973631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15978081, 26973631; Product type r: regulator" /codon_start=1 /transl_table=11 /product="positive regulator of hxlAB expression (formaldehyde sensing)" /protein_id="NP_388229.2" /db_xref="EnsemblGenomes-Gn:BSU03470" /db_xref="EnsemblGenomes-Tr:CAB12141" /db_xref="GOA:P42406" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11184" /db_xref="UniProtKB/Swiss-Prot:P42406" /translation="MSRMDDKRFNCEKELTLAVIGGKWKMLILWHLGKEGTKRFNELK TLIPDITQKILVNQLRELEQDMIVHREVYPVVPPKVEYSLTPHGESLMPILEAMYEWG KGYMELIDIDKNVMKESL*" /label="hxlR CDS" gene 357599..357961 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /label="hxlR gene" downshifts 357945 /Source="Nicolas_upshifts" /id="D153" /incds=0 /nref=14 /ntot=154 /MaxReadThrough="3.13609" /MaxDrop="3.66949" /score="20.4643411" /energy="-9.6" /TU="U267" /idTUdmin="U263" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 358208..358211 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 358226..358245 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 358234..358534 /Source="Nicolas_S_feature" /locus_tag="new_376667_376967" /HighExp="HiOs, T-1.10H, T5.0H, T4.0H, T-1.40H, S2, M9-stat, T3.30H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.20585600000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S126" upshifts 358234 /Source="Nicolas_upshifts" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="upshifts" CDS 358535..369298 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388230.2" /db_xref="EnsemblGenomes-Gn:BSU03480" /db_xref="EnsemblGenomes-Tr:CAB12142" /db_xref="GOA:P27206" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10168" /db_xref="UniProtKB/Swiss-Prot:P27206" /translation="MEITFYPLTDAQKRIWYTEKFYPHTSISNLAGIGKLVSADAIDY VLVEQAIQEFIRRNDAMRLRLRLDENGEPVQYISEYRPVDIKHTDTTEDPNAIEFISQ WSREETKKPLPLYDCDLFRFSLFTIKENEVWFYANVHHVISDGISMNILGNAIMHIYL ELASGSETKEGISHSFIDHVLSEQEYAQSKRFEKDKAFWNKQFESVPELVSLKRNASA GGSLDAERFSKDVPEALHQQILSFCEANKVSVLSVFQSLLAAYLYRVSGQNDVVTGTF MGNRTNAKEKQMLGMFVSTVPLRTNIDGGQAFSEFVKDRMKDLMKTLRHQKYPYNLLI NDLRETKSSLTKLFTVSLEYQVMQWQKEEDLAFLTEPIFSGSGLNDVSIHVKDRWDTG KLTIDFDYRTDLFSREEINMICERMITMLENALTHPEHTIDELTLISDAEKEKLLARA GGKSVSYRKDMTIPELFQEKAELLSDHPAVVFEDRTLSYRTLHEQSARIANVLKQKGV GPDSPVAVLIERSERMITAIMGILKAGGAYVPIDPGFPAERIQYILEDCGADFILTES KVAAPEADAELIDLDQAIEEGAEESLNADVNARNLAYIIYTSGTTGRPKGVMIEHRQV HHLVESLQQTIYQSGSQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKKTVTNGA ALTAYYRKNSIEATDGTPAHLQMLAAAGDFEGLKLKHMLIGGEGLSSVVADKLLKLFK EAGTAPRLTNVYGPTETCVDASVHPVIPENAVQSAYVPIGKALGNNRLYILDQKGRLQ PEGVAGELYIAGDGVGRGYLHLPELTEEKFLQDPFVPGDRMYRTGDVVRWLPDGTIEY LGREDDQVKVRGYRIELGEIEAVIQQAPDVAKAVVLARPDEQGNLEVCAYVVQKPGSE FAPAGLREHAARQLPDYMVPAYFTEVTEIPLTPSGKVDRRKLFALEVKAVSGTAYTAP RNETEKAIAAIWQDVLNVEKAGIFDNFFETGGHSLKAMTLLTKIHKETGIEIPLQFLF EHPTITALAEEADHRESKAFAVIEPAEKQEHYPLSLAQQRTYIVSQFEDAGVGYNMPA AAILEGPLDIQKLERAFQGLIRRHESLRTSFVLENSTPRQKIHDSVDFNIEMIERGGR SDEAIMASFVRTFDLAKAPLFRIGLLGLEENRHMLLFDMHHLISDGVSIGIMLEELAR IYKGEQLPDLRLQYKDYAVWQSRQAAEGYKKDQAYWKEVFAGELPVLQLLSDYPRPPV QSFEGDRVSIKLDAGVKDRLNRLAEQNGATLYMVMLSAYYTLLSKYTGQDDIIVGTPS AGRNHSDTEGIIGMFVNTLAIRSEVKQNETFTQLISRVRKRVLDAFSHQDYPFEWLVE DLNIPRDVSRHPLFDTMFSLQNATEGIPAVGDLSLSVQETNFKIAKFDLTVQARETDE GIEIDVDYSTKLFKQSTADRLLTHFARLLEDAAADPEKPISEYKLLSEEEAASQIQQF NPGRTPYPKDKTIVQLFEEQAANTPDHTALQYEGESLTYRELNERANRLARGILSLGA GEGRTAAVLCERSMDMIVSILAVLKSGSAYVPIDPEHPIQRMQHFFRDSGAKVLLTQR KLKALAEEAEFKGVIVLADEEESYHADARNLALPLDSAAMANLTYTSGTTGTPKGNIV THANILRTVKETNYLSITEQDTILGLSNYVFDAFMFDMFGSLLNGAKLVLIPKETVLD MARLSRVIERENISILMITTALFHLLVDLNPACLSTLRKIMFGGERASVEHVRKALQT VGKGKLLHMYGPSESTVFATYHPVDELEEHTLSVPIGKPVSNTEVYILDRTGHVQPAG IAGELCVSGEGLVKGYYNRPELTEEKFVPHPFTSGERMYKTGDLARWLPNGDIEFIGR IDHQVKIRGQRIELGEIEHQLQTHDRVQESVVLAVDQGAGDKLLCAYYVGEGDISSQE MREHAAKDLPAYMVPAVFIQMDELPLTGNGKIDRRALPIPDANVSRGVSYVAPRNGTE QKVADIWAQVLQAEQVGAYDHFFDIGGHSLAGMKMLALVHQELGVELSLKDLFQSPTV EGLAQVIASAEKGTAASISPAEKQDTYPVSSPQKRMYVLQQLEDAQTSYNMPAVLRLT GELDVERLNSVMQQLMQRHEALRTTFEIKDGETVQRIWEEAECEIAYFEAPEEETERI VSEFIKPFKIDQLPLFRIGLIKHSDTEHVLLFDMHHIISDGASVGVLIEELSKLYDGE TLEPLRIQYKDYAVWQQQFIQSELYKKQEEHWLKELDGELPVLTLPTDYSRPAVQTFE GDRIAFSLEAGKADALRRLAKETDSTLYMVLLASYSAFLSKISGQDDIIVGSPVAGRS QADVSRVIGMFVNTLALRTYPKGEKTFADYLNEVKETALSAFDAQDYPLEDLIGNVQV QRDTSRNPLFDAVFSMQNANIKDLTMKGIQLEPHPFERKTAKFDLTLTADETDGGLTF VLEYNTALFKQETIERWKQYWMELLDAVTGNPNQPLSSLSLVTETEKQALLEAWKGKA LPVPTDKTVHQLFEETAQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDD RVGVLTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISV PDSYTGDVILLDGSRTILSLPLDENDEENPETAVTAENLAYMIYTSGTTGQPKGVMVE HHALVNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIEEAIRLD IVRLNDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNY GPTENTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLA RGYLNREDETAKRFVADPFVPGERMYRTGDLVKWTGGGIEYIGRIDQQVKVRGYRIEL SEIEVQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPESADIEALKSALKETLPDYMIP AFWVTLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEV GVTDNFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQ GPVEGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDAL RMVYREGQEDVIQYNRGLEAASAQLEVIQIEGQAADYEDRIEREAERLQSSIDLQEGG LLKAGLFQAEDGDHLLLAIHHLVVDGVSWRILLEDFAAVYTQLEQGNEPVLPQKTHSF AEYAERLQDFANSKAFLKEKEYWRQLEEQAVAAKLPKDRESGDQRMKHTKTIEFSLTA EETEQLTTKVHEAYHTEMNDILLTAFGLAMKEWTGQDRVSVHLEGHGREEIIEDLTIS RTVGWFTSMYPMVLDMKHADDLGYQLKQMKEDIRHVPNKGVGYGILRYLTAPEHKEDV AFSIQPDVSFNYLGQFDEMSDAGLFTRSELPSGQSLSPETEKPNALDVVGYIENGKLT MSLAYHSLEFHEKTVQTFSDSFKAHLLRIIEHCLSQDGTELTPSDLGDDDLTLDELDK LMEIF*" /label="srfAA CDS" gene 358535..369298 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /label="srfAA gene" CDS 369311..380062 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388231.2" /db_xref="EnsemblGenomes-Gn:BSU03490" /db_xref="EnsemblGenomes-Tr:CAB12143" /db_xref="GOA:Q04747" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10169" /db_xref="UniProtKB/Swiss-Prot:Q04747" /translation="MSKKSIQKVYALTPMQEGMLYHAMLDPHSSSYFTQLELGIHGAF DLEIFEKSVNELIRSYDILRTVFVHQQLQKPRQVVLAERKTKVHYEDISHADENRQKE HIERYKQDVQRQGFNLAKDILFKVAVFRLAADQLYLVWSNHHIMMDGWSMGVLMKSLF QNYEALRAGRTPANGQGKPYSDYIKWLGKQDNEEAESYWSERLAGFEQPSVLPGRLPV KKDEYVNKEYSFTWDETLVARIQQTANLHQVTGPNLFQAVWGIVLSKYNFTDDVIFGT VVSGRPSEINGIETMAGLFINTIPVRVKVERDAAFADIFTAVQQHAVEAERYDYVPLY EIQKRSALDGNLLNHLVAFENYPLDQELENGSMEDRLGFSIKVESAFEQTSFDFNLIV YPGKTWTVKIKYNGAAFDSAFIERTAEHLTRMMEAAVDQPAAFVREYGLVGDEEQRQI VEVFNSTKAELPEGMAVHQVFEEQAKRTPASTAVVYEGTKLTYRELNAAANRLARKLV EHGLQKGETAAIMNDRSVETVVGMLAVLKAGAAYVPLDPALPGDRLRFMAEDSSVRMV LIGNSYTGQAHQLQVPVLTLDIGFEESEAADNLNLPSAPSDLAYIMYTSGSTGKPKGV MIEHKSILRLVKNAGYVPVTEEDRMAQTGAVSFDAGTFEVFGALLNGAALYPVKKETL LDAKQFAAFLREQSITTMWLTSPLFNQLAAKDAGMFGTLRHLIIGGDALVPHIVSKVK QASPSLSLWNGYGPTENTTFSTSFLIDREYGGSIPIGKPIGNSTAYIMDEQQCLQPIG APGELCVGGIGVARGYVNLPELTEKQFLEDPFRPGERIYRTGDLARWLPDGNIEFLGR IDNQVKVRGFRIELGEIETKLNMAEHVTEAAVIIRKNKADENEICAYFTADREVAVSE LRKTLSQSLPDYMVPAHLIQMDSLPLTPNGKINKKELPAPQSEAVQPEYAAPKTESEK KLAEIWEGILGVKAGVTDNFFMIGGHSLKAMMMTAKIQEHFHKEVPIKVLFEKPTIQE LALYLEENESKEEQTFEPIRQASYQQHYPVSPAQRRMYILNQLGQANTSYNVPAVLLL EGEVDKDRLENAIQQLINRHEILRTSFDMIDGEVVQTVHKNISFQLEAAKGREEDAEE IIKAFVQPFELNRAPLVRSKLVQLEEKRHLLLIDMHHIITDGSSTGILIGDLAKIYQG ADLELPQIHYKDYAVWHKEQTNYQKDEEYWLDVFKGELPILDLPADFERPAERSFAGE RVMFGLDKQITAQIKSLMAETDTTMYMFLLAAFNVLLSKYASQDDIIVGSPTAGRTHP DLQGVPGMFVNTVALRTAPAGDKTFAQFLEEVKTASLQAFEHQSYPLEELIEKLPLTR DTSRSPLFSVMFNMQNMEIPSLRLGDLKISSYSMLHHVAKFDLSLEAVEREEDIGLSF DYATALFKDETIRRWSRHFVNIIKAAAANPNVRLSDVDLLSSAETAALLEERHMTQIT EATFAALFEKQAQQTPDHSAVKAGGNLLTYRELDEQANQLAHHLRAQGAGNEDIVAIV MDRSAEVMVSILGVMKAGAAFLPIDPDTPEERIRYSLEDSGAKFAVVNERNMTAIGQY EGIIVSLDDGKWRNESKERPSSISGSRNLAYVIYTSGTTGKPKGVQIEHRNLTNYVSW FSEEAGLTENDKTVLLSSYAFDLGYTSMFPVLLGGGELHIVQKETYTAPDEIAHYIKE HGITYIKLTPSLFHTIVNTASFAKDANFESLRLIVLGGEKIIPTDVIAFRKMYGHTEF INHYGPTEATIGAIAGRVDLYEPDAFAKRPTIGRPIANAGALVLNEALKLVPPGASGQ LYITGQGLARGYLNRPQLTAERFVENPYSPGSLMYKTGDVVRRLSDGTLAFIGRADDQ VKIRGYRIEPKEIETVMLSLSGIQEAVVLAVSEGGLQELCAYYTSDQDIEKAELRYQL SLTLPSHMIPAFFVQVDAIPLTANGKTDRNALPKPNAAQSGGKALAAPETALEESLCR IWQKTLGIEAIGIDDNFFDLGGHSLKGMMLIANIQAELEKSVPLKALFEQPTVRQLAA YMEASAVSGGHQVLKPADKQDMYPLSSAQKRMYVLNQLDRQTISYNMPSVLLMEGELD ISRLRDSLNQLVNRHESLRTSFMEANGEPVQRIIEKAEVDLHVFEAKEDEADQKIKEF IRPFDLNDAPLIRAALLRIEAKKHLLLLDMHHIIADGVSRGIFVKELALLYKGEQLPE PTLHYKDFAVWQNEAEQKERMKEHEAYWMSVLSGELPELDLPLDYARPPVQSFKGDTI RFRTGSETAKAVEKLLAETGTTLHMVLHAVFHVFLSKISGQRDIVIGSVTAGRTNADV QDMPGMFVNTLALRMEAKEQQTFAELLELAKQTNLSALEHQEYPFEDLVNQLDLPRDM SRNPLFNVMVTTENPDKEQLTLQNLSISPYEAHQGTSKFDLTLGGFTDENGIGLQLEY ATDLFAKETAEKWSEYVLRLLKAVADNPNQPLSSLLLVTETEKQALLEAWKGKALPVP TDKTVHQLFEETVQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDDRVGV LTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISVPDSY TGDVILLDGSRTILSLPLDENDEGNPETAVTAENLAYMIYTSGTTGQPKGVMVEHHAL VNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIDEAIRLDIVRL NDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNYGPTE NTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLARGYL NREDETAKRFVADPFVPGERMYRTGDLVKWVNGGIEYIGRIDQQVKVRGYRIELSEIE VQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPETADIEALKSTLKETLPDYMIPAFWV TLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEVGVTD NFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQGPVE GEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVY REENGDIVQVYKPIGESKVSFEIVDLYGSDEEMLRSQIKLLANKLQSSLDLRNGPLLK AEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDW AEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTAEDTK HLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVG WFTAQYPVVLDISDADASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEIS FNYLGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKE FERATVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGDIFDMLEENL K*" /label="srfAB CDS" gene 369311..380062 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /label="srfAB gene" CDS 372447..372587 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" /label="comS CDS" gene 372447..372587 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /label="comS gene" CDS 380099..383926 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388233.2" /db_xref="EnsemblGenomes-Gn:BSU03510" /db_xref="EnsemblGenomes-Tr:CAB12145" /db_xref="GOA:Q08787" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="PDB:1JMK" /db_xref="PDB:2VSQ" /db_xref="SubtiList:BG10170" /db_xref="UniProtKB/Swiss-Prot:Q08787" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVK GSLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSE QTAKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQ DLFKVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEGFEGQTTFAEQ RKKQKDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLA FGTVVSGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKRLQEQSLQSEPHQYV PLYDIQSQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMA SPGDEMLIKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFL LTGLNPPAQAHETKPLTYWFKEAVNANPDAPALTYSGQTLSYRELDEEANRIARRLQK HGAGKGSVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLL THQEMKEQAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKG NITTHANIQGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHT LLDTERLTDLILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKA LRIMGPGKLINCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQ PFGAVGELCISGMGVSKGYVNRADLTKEKFIENPFKPGETLYRTGDLARWLPDGTIEY AGRIDDQVKIRGHRIELEEIEKQLQEYPGVKDAVVVADRHESGDASINAYLVNRTQLS AEDVKAHLKKQLPAYMVPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNE MEETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAP TIAGISAYLKNGGSDGLQDVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCA FDFIEEEDRLDRYADLIQKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMV DSYKKQGVSDLDGRTVESDVEALMNVNRDNEALNSEAVKHGLKQKTHAFYSYYVNLIS TGQVKADIDLLTSGADFDMPEWLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAEI LLEFLNTQTVTVS*" /label="srfAC CDS" gene 380099..383926 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /label="srfAC gene" CDS 383955..384683 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388234.1" /db_xref="EnsemblGenomes-Gn:BSU03520" /db_xref="EnsemblGenomes-Tr:CAB12146" /db_xref="GOA:Q08788" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR012223" /db_xref="InterPro:IPR029058" /db_xref="PDB:2K2Q" /db_xref="PDB:2RON" /db_xref="SubtiList:BG10171" /db_xref="UniProtKB/Swiss-Prot:Q08788" /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLA AEPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLERE GIFPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSF RSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMF LLSQTEEVAERIFAILNQHPIIQP*" /label="srfAD CDS" gene 383955..384683 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /label="srfAD gene" downshifts 384665 /Source="Nicolas_upshifts" /id="D154" /incds=0 /nref=196 /ntot=261 /MaxReadThrough="4.65721" /MaxDrop="6.48992" /score="24.9581454" /energy="-11.1" /TU="U268" /idTUdmin="U268" /TUdmin="-1339" /isTUend="FALSE" /label="downshifts" promotor_-35 384721..384728 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 384731 /Source="Nicolas_upshifts" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 384740..384759 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 384784..386010 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15849754, 16850406, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter" /protein_id="NP_388235.2" /db_xref="EnsemblGenomes-Gn:BSU03530" /db_xref="EnsemblGenomes-Tr:CAB12147" /db_xref="GOA:Q08791" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10172" /db_xref="UniProtKB/Swiss-Prot:Q08791" /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADR SLISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFS AIYGVLGGIGYSCAVGVTTQYFISCWFDTHKGLALAILTNANSAGLLLLSPIWAAAPY HAGWQSTYTILGIVMAAVLLPLLVFGMKHPPHAQAETVKKSYDWRGFWNVMKQSRLIH ILYFGVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLG SRSVMLSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLTAASISE SYQTGLIGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIEL VPFLDKQKAKETHHSI*" /label="srfT CDS" gene 384784..386010 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /label="srfT gene" downshifts 386004 /Source="Nicolas_upshifts" /id="D155" /incds=0 /nref=15 /ntot=198 /MaxReadThrough="2.67601" /MaxDrop="4.06773" /score="7.33278866" /energy="-13.2" /TU="NA" /idTUdmin="U268" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(386025..386582) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 21965396" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388236.1" /db_xref="EnsemblGenomes-Gn:BSU03540" /db_xref="EnsemblGenomes-Tr:CAB12148" /db_xref="GOA:Q08793" /db_xref="InterPro:IPR025588" /db_xref="SubtiList:BG10173" /db_xref="UniProtKB/Swiss-Prot:Q08793" /translation="MIQYASESINLPGEITFKDVREIFFYQIAKISCFYFLLFCAIFA AVNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKS KRTYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKHFFHSEE EMNRFKEIILKNTETKKLKFKKDQH*" /label="ycxB CDS" gene complement(386025..386582) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /label="ycxB gene" promotor_no_box complement(386040..386140) /Source="Nicolas_upshift_promotors" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(386062) /Source="Nicolas_upshifts" /id="D156" /incds=0 /nref=46 /ntot=241 /MaxReadThrough="0.9216" /MaxDrop="4.25654" /score="8.42655219" /energy="-14.3" /TU="U270" /idTUdmin="U271" /TUdmin=18 /isTUend="TRUE" /label="downshifts" upshifts complement(386080) /Source="Nicolas_upshifts" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(386611..386630) /Source="Nicolas_upshift_promotors" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(386613) /Source="Nicolas_upshifts" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(386636..387574) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388237.2" /db_xref="EnsemblGenomes-Gn:BSU03550" /db_xref="EnsemblGenomes-Tr:CAB12149" /db_xref="GOA:Q08794" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10174" /db_xref="UniProtKB/Swiss-Prot:Q08794" /translation="MVKHQQTPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRF TIAFAAATVPILFGWVKLSIRVKDVIDILPLALLYPALFFSFQAFGLVYSSSSEAGII QAAIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLIL LSALSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPF REPGFVLAIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGFVILNES LAWYHLAGAVCIMIGVVGSNINLEKKTKRPGMPAKK*" /label="ycxC CDS" gene complement(386636..387574) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /label="ycxC gene" promotor_-10 complement(387613..387631) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(387620) /Source="Nicolas_upshifts" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(387647..387652) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 387698..389032 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 26585522; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388238.1" /db_xref="EnsemblGenomes-Gn:BSU03560" /db_xref="EnsemblGenomes-Tr:CAB12150" /db_xref="GOA:Q08792" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10175" /db_xref="UniProtKB/Swiss-Prot:Q08792" /translation="MEKYMSLLTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVI RALQELEKRHLIYSVPKSGYYIVKKSGKSKSGQPGPIDFATSAPDPDVFPYLDFQHCI NKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLATQQVFADERHIFITSGVQQALSLLCA MPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAKVERLFQTESIKFF YTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSS HVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGM YGRHKEKIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASR VIHRLEKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVKLLMSHL*" /label="ycxD CDS" gene 387698..389032 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /label="ycxD gene" CDS complement(389027..389194) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="C-terminal part of 4'-phosphopantetheinyl transferase (Surfactin synthetase-activating enzyme)" /db_xref="PSEUDO:CAX52545.1" /translation="MRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAVHPDFPE DITMVSYEELL*" /label="sfpAc CDS" gene complement(389027..389194) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /pseudo /label="sfpAc gene" CDS complement(389205..389702) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="N-terminal part of 4'-phosphopantetheinyl transferase (surfactin synthetase-activating enzyme)" /db_xref="GOA:P39135" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1QR0" /db_xref="PDB:2GE0" /db_xref="PDB:2GE1" /db_xref="PDB:4MRT" /db_xref="PSEUDO:CAB12151.2" /db_xref="SubtiList:BG10176" /db_xref="UniProtKB/Swiss-Prot:P39135" /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRT LLGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQ PIGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQGRQR LIASA*" /label="sfpAn CDS" gene complement(389205..389702) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /pseudo /label="sfpAn gene" misc_feature complement(389729..389748) /Source="Nicolas_upshift_promotors" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(389741) /Source="Nicolas_upshifts" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" CDS complement(389807..390454) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /function="15.11: Biosynthesis of natural products" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17827323, 14762003, 16707694, 17827323, 25288929; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein regulating antibiotic production" /protein_id="NP_388240.2" /db_xref="EnsemblGenomes-Gn:BSU03580" /db_xref="EnsemblGenomes-Tr:CAB12152" /db_xref="GOA:O34927" /db_xref="SubtiList:BG12779" /db_xref="UniProtKB/Swiss-Prot:O34927" /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSL FQHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPALST YTGSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMELTI LFAAWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH*" /label="yczE CDS" gene complement(389807..390454) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /label="yczE gene" promotor_-10 complement(390483..390502) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(390486) /Source="Nicolas_upshifts" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(390518..390522) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(390623..390774) /Source="Nicolas_S_feature" /locus_tag="new_409056_409207_c" /HighExp="G180, G135, dia15, H2O2, Diami, S8, Oxctl, G150, LPhT, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S127" CDS complement(390775..391518) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 16513748, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 16513748, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (ATP-binding protein)" /protein_id="NP_388241.2" /db_xref="EnsemblGenomes-Gn:BSU03590" /db_xref="EnsemblGenomes-Tr:CAB12153" /db_xref="GOA:P39456" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11185" /db_xref="UniProtKB/Swiss-Prot:P39456" /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLL RCLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENV MEGPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPE LMLFDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVI VEQGPPEQIFSAPKEERTQRFLNRILNPL*" /label="tcyC CDS" gene complement(390775..391518) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /label="tcyC gene" downshifts complement(390831) /Source="Nicolas_upshifts" /id="D157" /incds=0 /nref=72 /ntot=232 /MaxReadThrough="4.60958" /MaxDrop="4.44283" /score="1.62131565" /energy="-12.6" /TU="U275" /idTUdmin="U276" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(391532..392236) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 15849754, 16850406, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 15849754, 16850406, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (permease)" /protein_id="NP_388242.1" /db_xref="EnsemblGenomes-Gn:BSU03600" /db_xref="EnsemblGenomes-Tr:CAB12154" /db_xref="GOA:P42200" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11186" /db_xref="UniProtKB/Swiss-Prot:P42200" /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFI FGMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFP SAVIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIP PLSNTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLS LVQHVIERRLDRYVAK*" /label="tcyB CDS" gene complement(391532..392236) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /label="tcyB gene" CDS complement(392223..393029) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (substrate-binding lipoprotein)" /protein_id="NP_388243.2" /db_xref="EnsemblGenomes-Gn:BSU03610" /db_xref="EnsemblGenomes-Tr:CAB12155" /db_xref="GOA:P42199" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11187" /db_xref="UniProtKB/Swiss-Prot:P42199" /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKK GVLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLN SKRFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLT SNYNKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAF ETGEPQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK*" /label="tcyA CDS" gene complement(392223..393029) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /label="tcyA gene" promotor_-10 complement(393078..393097) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393090) /Source="Nicolas_upshifts" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(393111..393118) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(393145..394017) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17295427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17295427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="HTH-type transcriptional regulator BsdA (LysR family)" /protein_id="NP_388244.1" /db_xref="EnsemblGenomes-Gn:BSU03620" /db_xref="EnsemblGenomes-Tr:CAB12156" /db_xref="GOA:P94403" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12022" /db_xref="UniProtKB/Swiss-Prot:P94403" /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELG VVLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYC AALMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQL DDIPCVLVLSDEAGYPCGDTIKMVDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPR IVCECHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTD SYLPKPAQQFLDLF*" /label="bsdA CDS" gene complement(393145..394017) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /label="bsdA gene" promotor_-10 complement(393755..393773) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393762) /Source="Nicolas_upshifts" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(393788..393794) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 394071..394078 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(394086..394105) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-10" promotor_-10 394092..394111 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(394092) /Source="Nicolas_upshifts" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="upshifts" upshifts 394100 /Source="Nicolas_upshifts" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="upshifts" CDS 394107..394721 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10919793, 15979273, 17295427, 18388975, 26083743, 26658822, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase-flavin prenyltransferase subunit" /protein_id="NP_388245.1" /db_xref="EnsemblGenomes-Gn:BSU03630" /db_xref="EnsemblGenomes-Tr:CAB12157" /db_xref="GOA:P94404" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR004507" /db_xref="InterPro:IPR032901" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG12023" /db_xref="UniProtKB/Swiss-Prot:P94404" /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHL VVSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSL ASIRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMP AFYNRPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA*" /label="ubiX CDS" gene 394107..394721 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /label="ubiX gene" promotor_-35 complement(394119..394126) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-35" CDS 394724..396145 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /EC_number="4.1.1.61" /EC_number="4.1.1.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11029449, 15979273, 17295427, 18388975, 26658822, 26337367; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phenolic acid decarboxylase subunit;1,4-dihydroxy-2-naphtoate-heptaprenyl diphosphatedecarboxylase" /protein_id="NP_388246.1" /db_xref="EnsemblGenomes-Gn:BSU03640" /db_xref="EnsemblGenomes-Tr:CAB12158" /db_xref="GOA:P94405" /db_xref="InterPro:IPR002830" /db_xref="InterPro:IPR012349" /db_xref="InterPro:IPR032902" /db_xref="SubtiList:BG12024" /db_xref="UniProtKB/Swiss-Prot:P94405" /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGASARAASNLGD KSPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMP VKREETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQN VGIYRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPL LYDQSEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTG HYSGGRSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPN EIVAVNAMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFN LPQVMWALSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHY SQPLDSPLTTKEWEQKLMDLMNK*" /label="bsdC CDS" gene 394724..396145 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /label="bsdC gene" CDS 396162..396389 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /EC_number="4.1.1.91" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15979273, 17295427, 18388975, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase subunit" /protein_id="YP_003097675.1" /db_xref="EnsemblGenomes-Gn:BSU03651" /db_xref="EnsemblGenomes-Tr:CAX52546" /db_xref="GOA:C0H3U9" /db_xref="UniProtKB/Swiss-Prot:C0H3U9" /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESI TNPEKYNPAFKIDPKETETAIEVPAVPERKA*" /label="bsdD CDS" gene 396162..396389 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /label="bsdD gene" CDS 396386..396850 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15979273, 18388975; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN-binding enzyme subunit" /protein_id="NP_388247.2" /db_xref="EnsemblGenomes-Gn:BSU03652" /db_xref="EnsemblGenomes-Tr:CAB12159" /db_xref="GOA:C0SPB5" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12025" /db_xref="UniProtKB/Swiss-Prot:C0SPB5" /translation="MIRVNCMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMI SAGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKD AEYERDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLSRWKKTLEDLKR*" /label="yclD CDS" gene 396386..396850 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /label="yclD gene" downshifts 396831 /Source="Nicolas_upshifts" /id="D158" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="3.32586" /MaxDrop="3.88166" /score="45.8937489" /energy="-15.1" /TU="NA" /idTUdmin="U278" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 396857..396858 /Source="Nicolas_upshift_promotors" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 396858 /Source="Nicolas_upshifts" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 396917..397762 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388248.2" /db_xref="EnsemblGenomes-Gn:BSU03660" /db_xref="EnsemblGenomes-Tr:CAB12160" /db_xref="GOA:P94407" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12026" /db_xref="UniProtKB/Swiss-Prot:P94407" /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQ KYQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMAL EYARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIENLPQDID KDPERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLLQRLA DVRMPVYIGLGRYDYLVAPVSLWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFR KWLDQ*" /label="yclE CDS" gene 396917..397762 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /label="yclE gene" CDS complement(397802..399280) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8458848, 11717292, 15849754, 16204487, 16850406, 17496096, 23144141, 25966844; Product type t: transporter" /codon_start=1 /transl_table=11 /product="di-tripeptide-proton ABC symporter" /protein_id="NP_388249.2" /db_xref="EnsemblGenomes-Gn:BSU03670" /db_xref="EnsemblGenomes-Tr:CAB12175" /db_xref="GOA:P94408" /db_xref="InterPro:IPR000109" /db_xref="InterPro:IPR005279" /db_xref="InterPro:IPR018456" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12027" /db_xref="UniProtKB/Swiss-Prot:P94408" /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRA ILLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGG IFIMFGHIALAYPGSSIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSI FYMGINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNV PNPLSKKSAIGTGIGVIIVAIAVIISVQTGVLTIKRFIDLVSILGILIPVIYFIIMFT SKKADKTEKSRLAAYVPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWF QSLNPLFVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEAL VSPLWLVLSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQV AGLFDKIPETMYFGTIGLISIVLGGILLLLSPVIKRAMKGVL*" /label="dtpT CDS" gene complement(397802..399280) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /label="dtpT gene" downshifts complement(397810) /Source="Nicolas_upshifts" /id="D159" /incds=0 /nref=17 /ntot=90 /MaxReadThrough="1.40624" /MaxDrop="3.91827" /score="43.5753464" /energy="-21" /TU="NA" /idTUdmin="U281" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 399307..399309 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(399308..399327) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399318 /Source="Nicolas_upshifts" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 399326..399344 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399328) /Source="Nicolas_upshifts" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(399330..>399513) /Source="Nicolas_S_feature" /locus_tag="new_417763_418267_c" /HighExp="S3, S4, LoTm, S5, S6, T5.0H, T4.0H, M9-stat, S8, T3.30H" /AntisenseName="yclG" /AntisenseCor="0.33937447534762299" /AntisenseRegPval="-7.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S128" promotor_-35 complement(399342..399349) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 399498..399507 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 399513..399514 /note_="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_011" downshifts 399519 /Source="Nicolas_upshifts" /id="D172" /incds=0 /nref=173 /ntot=262 /MaxReadThrough="0.52252" /MaxDrop="5.32898" /score="20.7855667" /energy="-7.4" /TU="NA" /idTUdmin="U297" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(399529..400968) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /experiment="publication(s) with functional evidences, PMID:15223311, 24127574, 25388514, 27640111, 28348215, 28412355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223311, 24127574, 25388514, 27640111, 28348215, 28412355; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)" /protein_id="NP_388271.1" /db_xref="EnsemblGenomes-Gn:BSU03890" /db_xref="EnsemblGenomes-Tr:CAB12197" /db_xref="GOA:P94426" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4MGR" /db_xref="PDB:4N0B" /db_xref="PDB:4TV7" /db_xref="PDB:5T4J" /db_xref="PDB:5T4K" /db_xref="PDB:5X03" /db_xref="SubtiList:BG12042" /db_xref="UniProtKB/Swiss-Prot:P94426" /translation="MDITITLDRSEQADYIYQQIYQKLKKEILSRNLLPHSKVPSKRE LAENLKVSVNSVNSAYQQLLAEGYLYAIERKGFFVEELDMFSAEEHPPFALPDDLKEI HIDQSDWISFSHMSSDTDHFPIKSWFRCEQKAASRSYRTLGDMSHPQGIYEVRAAITR LISLTRGVKCRPEQMIIGAGTQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKNAGKQ VKTIMLDEKGMSIAEITRQQPDVLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYI IEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLRISYMVLPPELLRAYK QRGYDLQTCSSLTQLTLQEFIESGEYQKHIKKMKQHYKEKRERLITALEAEFSGEVTV KGANAGLHFVTEFDTRRTEQDILSHAAGLQLEIFGMSRFNLKENKRQTGRPALIIGFA RLKEEDIQEGVQRLFKAVYGHKKIPVTGD*" /label="gabR CDS" gene complement(399529..400968) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /label="gabR gene" promotor_-10 complement(399853..399864) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399859) /Source="Nicolas_upshifts" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(399878..399884) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(401011..401030) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 401012..401019 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(401018) /Source="Nicolas_upshifts" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 401033..401052 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 401037 /Source="Nicolas_upshifts" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(401041..401048) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 401075..402385 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /EC_number="2.6.1.19" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-aminobutyrate aminotransferase" /protein_id="NP_388272.1" /db_xref="EnsemblGenomes-Gn:BSU03900" /db_xref="EnsemblGenomes-Tr:CAB12198" /db_xref="GOA:P94427" /db_xref="InterPro:IPR004632" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12043" /db_xref="UniProtKB/Swiss-Prot:P94427" /translation="MSQTTASITTAQWQQKRDQFVSKGVSNGNRSLAVKGEGAELYDL DGRRFIDFAGAIGTLNVGHSHPKVVEAVKRQAEELIHPGFNVMMYPTYIELAEKLCGI APGSHEKKAIFLNSGAEAVENAVKIARKYTKRQGVVSFTRGFHGRTNMTMSMTSKVKP YKFGFGPFAPEVYQAPFPYYYQKPAGMSDESYDDMVIQAFNDFFIASVAPETVACVVM EPVQGEGGFIIPSKRFVQHVASFCKEHGIVFVADEIQTGFARTGTYFAIEHFDVVPDL ITVSKSLAAGLPLSGVIGRAEMLDAAAPGELGGTYAGSPLGCAAALAVLDIIEEEGLN ERSEEIGKIIEDKAYEWKQEFPFIGDIRRLGAMAAIEIVKDPDTREPDKTKAAAIAAY ANQNGLLLLTAGINGNIIRFLTPLVISDSLLNEGLSILEAGLRA*" /label="gabT CDS" gene 401075..402385 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /label="gabT gene" promotor_-35 402263..402269 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 402283..402301 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 402291 /Source="Nicolas_upshifts" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 402387..402394 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 402409..402428 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 402418 /Source="Nicolas_upshifts" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" CDS 402454..403842 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /EC_number="1.2.1.24" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate-semialdehyde dehydrogenase" /protein_id="NP_388273.1" /db_xref="EnsemblGenomes-Gn:BSU03910" /db_xref="EnsemblGenomes-Tr:CAB12199" /db_xref="GOA:P94428" /db_xref="InterPro:IPR010102" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="SubtiList:BG12044" /db_xref="UniProtKB/Swiss-Prot:P94428" /translation="MPDQLTVYNPATGEEIKTIPQQSATEVEEAIERSHQAFKTWSKT SANERTSLLKKWYELIVEHKEELADLITKENGKPYQEAVGEVLYGAGYIEWFAEEAKR VYGRTVPAPTTGKRIVVTRQPVGPVAAITPWNFPNAMITRKAAPALAAGCTFIIKPAP DTPLSAYELARLAYEAGIPKDVLQVVIGDGEEIGNVFTSSPKIRKITFTGSTPVGKIL MKNSADTVKHVSMELGGHAPLIVDEDADIDLAVEQAMASKYRNAGQTCVCANRLIVHE SIKDEFAAKLSEQVSKLKVGNGLEEGVNVGPIINKRGFEKIVSQIDDAVEKGAKVIAG GTYDRNDDKGCYFVNPTVLTDVDTSMNIMHEETFGPVAPIVTFSDIDEAIQLANDTPY GLAAYFFTENYRRGIYISENLEYGIIGWNDGGPSAVQAPFGGMKESGIGREGGSEGIE PYLETKYLSIGL*" /label="gabD CDS" gene 402454..403842 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /label="gabD gene" downshifts 403850 /Source="Nicolas_upshifts" /id="D173" /incds=0 /nref=107 /ntot=240 /MaxReadThrough="0.105510000000001" /MaxDrop="6.52053" /score="38.677658" /energy="-19.9" /TU="NA" /idTUdmin="U301" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 403900..403906 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 403920..403931 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 403921 /Source="Nicolas_upshifts" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="upshifts" CDS 403965..404828 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438764, 15849754, 16850406, 19054326, 21564334, 27329749; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose uptake protein" /protein_id="NP_388274.1" /db_xref="EnsemblGenomes-Gn:BSU03920" /db_xref="EnsemblGenomes-Tr:CAB12200" /db_xref="GOA:P40420" /db_xref="InterPro:IPR010651" /db_xref="SubtiList:BG11066" /db_xref="UniProtKB/Swiss-Prot:P40420" /translation="MDLLLALLPALFWGSIVLFNVKLGGGPYSQTLGTTIGALIVSIV IYFFVQPVLSLRIFIVGIVSGLFWSLGQANQLKSIQLMGVSKTMPISTGMQLVSTSLF GVIVFREWSTPIAITLGVLALIFIIVGIILTSLEDKNDKKEGEPSNLKKGILILLVST LGYLVYVVVARLFNVSGWSALLPQAIGMVVGGLVLTYRHKPFNKYAIRNILPGLIWAG GNMFLFISQPRVGVATSFSLSQMGIVISTLGGIFILREKKTKRQLIAIAIGIILIIAA AVFLGIAKTNS*" /label="glcU CDS" gene 403965..404828 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /label="glcU gene" CDS 404848..405633 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /EC_number="1.1.1.47" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2493633, 3141376, 6438057, 16912926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2493633, 3141376, 6438057, 16912926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="forespore glucose 1-dehydrogenase" /protein_id="NP_388275.1" /db_xref="EnsemblGenomes-Gn:BSU03930" /db_xref="EnsemblGenomes-Tr:CAB12201" /db_xref="GOA:P12310" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10545" /db_xref="UniProtKB/Swiss-Prot:P12310" /translation="MYPDLKGKVVAITGAASGLGKAMAIRFGKEQAKVVINYYSNKQD PNEVKEEVIKAGGEAVVVQGDVTKEEDVKNIVQTAIKEFGTLDIMINNAGLENPVPSH EMPLKDWDKVIGTNLTGAFLGSREAIKYFVENDIKGNVINMSSVHEVIPWPLFVHYAA SKGGIKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPKQKADVESMIPMGYI GEPEEIAAVAAWLASKEASYVTGITLFADGGMTQYPSFQAGRG*" /label="gdh CDS" gene 404848..405633 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /label="gdh gene" misc_feature 404953..404972 /Source="Nicolas_upshift_promotors" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 404953 /Source="Nicolas_upshifts" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 405041 /Source="Nicolas_upshifts" /id="D174" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.44884" /MaxDrop="2.47712" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U301" /TUdmin=1188 /isTUend="FALSE" /label="downshifts" downshifts 405635 /Source="Nicolas_upshifts" /id="D175" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="2.7861" /MaxDrop="4.2307" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U303" /TUdmin="-836" /isTUend="FALSE" /label="downshifts" CDS complement(405678..406292) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19168619, 22904286, 27010565, 26822828; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative membrane protein involved in copper intake" /protein_id="NP_388276.1" /db_xref="EnsemblGenomes-Gn:BSU03940" /db_xref="EnsemblGenomes-Tr:CAB12202" /db_xref="GOA:P94431" /db_xref="InterPro:IPR012533" /db_xref="SubtiList:BG12045" /db_xref="UniProtKB/Swiss-Prot:P94431" /translation="MLKKIALTLCPAIVGSLLFFTAPASAHVSVKPAESAAGSWETYT MKVPSEKNLPTTKVVLKMPKDVEFQQYEPIPGWKVSTQKHDDKSVSVTWEATDGGIQE GQFQQFTFVAKNPDKAEEAAWDAYQYYKDGSIVEWTGDEDADTPHSITNITSAKQVTD EHGATKTEDDSENSGSSALDITAMVLSAAAIILSVAALVKKKRA*" /label="cutI CDS" gene complement(405678..406292) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /label="cutI gene" downshifts complement(405689) /Source="Nicolas_upshifts" /id="D176" /incds=0 /nref=95 /ntot=219 /MaxReadThrough="0.879290000000001" /MaxDrop="6.67627" /score="21.5633403" /energy="-16" /TU="NA" /idTUdmin="U305" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(406305..407930) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15101989, 15849754, 16850406, 19168619, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 15849754, 16850406, 19168619, 22904286, 23012364; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper import permease subunit" /protein_id="NP_388277.2" /db_xref="EnsemblGenomes-Gn:BSU03950" /db_xref="EnsemblGenomes-Tr:CAB12203" /db_xref="GOA:C0SP95" /db_xref="InterPro:IPR007348" /db_xref="InterPro:IPR008457" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR032693" /db_xref="InterPro:IPR032694" /db_xref="SubtiList:BG12046" /db_xref="UniProtKB/Swiss-Prot:C0SP95" /translation="MKRNRWWIILLLFLVFLPKTSFAHAYIVKSSPGENSELKSAPAQ VEIEFNEPVEEGFHYIKVYNSNGDRVDTDKTEIKKDNHHIMTVKLKKNLPKDVYRAEW NAVSADGHPVSGVIPFSIGKADGGFSSQKAADSALNPGTAADRAILYTALSLFIGTVF FHLFWYKGKSEQLVKRTRRILTGSIAALGLALLLQLPIQTKANAGGGWGSAFQPGYIR ETLFETAGGSIWIIQAALFVLLALSVIPAIRKNRFSSFGYWTAPLIFFFGLLLAKAFT GHAAVVEEKTVGILMDFLHLTSASIWVGGIAALVLLLSKEWRQPDKTLAWETVRRFSP WALTAVGVILFSGLLNGFFIIRSMDSLFHTAYGQALLVKSGLFVFMLVLGAIHFLLTR KQRRTGISRTLKAEWAIGIAVLITAAVFTSLPSPPEPAPEPFYQTKAIENGQSVSLSI SPNQPGKNVFELRVTDHNGDPVKNIQQITLTVYKTGLSGSENKSTFTLKEKTKGVFQD QNLSINEKGNWKIKVHGLTGDFNEINIMFTKTN*" /label="cutJ CDS" gene complement(406305..407930) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /label="cutJ gene" CDS complement(407965..408537) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 22904286, 23012364; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of copper intake (CutR-Cu(+))" /protein_id="NP_388278.1" /db_xref="EnsemblGenomes-Gn:BSU03960" /db_xref="EnsemblGenomes-Tr:CAB12204" /db_xref="GOA:P94433" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR008719" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12047" /db_xref="UniProtKB/Swiss-Prot:P94433" /translation="MLPINRQQHILKWLKEEGSLRISDISARFGVSEMTVYRDVNQLV QSNQVIKTAGGITLPVRTPQTDHMCSYCLKPVNQAHSVQLITVNQDIEQLCCAHCAFL RYADKTEEVSHLICRDFLLQTTVSAGSAYFVVNAELNLHCCQPQAIPFATLDHAERFQ KGFGGAVCTFDQALEDMLQDRKKRCTCTKK*" /label="cutR CDS" gene complement(407965..408537) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /label="cutR gene" promotor_-10 complement(408559..408578) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(408574) /Source="Nicolas_upshifts" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(408592..408599) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 408659..408678 /Source="Nicolas_upshift_promotors" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 408671 /Source="Nicolas_upshifts" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="upshifts" CDS 408702..409055 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18307109, 27010565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative reductase or disulfide isomerase" /protein_id="NP_388279.1" /db_xref="EnsemblGenomes-Gn:BSU03970" /db_xref="EnsemblGenomes-Tr:CAB12205" /db_xref="GOA:P94434" /db_xref="SubtiList:BG12048" /db_xref="UniProtKB/Swiss-Prot:P94434" /translation="MKETPCPNCGKPLTGDMVRSSNVPCQFRCGHCRERLYEYKVSAP IMLVSLAAIVLLIYLLMLLRNAAGSVLPAVQHVPMAVFALVCAYPVFIVSERMIAKYV IQNGNIIYRGKRKGS*" /label="ycnL CDS" gene 408702..409055 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /label="ycnL gene" downshifts 409026 /Source="Nicolas_upshifts" /id="D177" /incds=0 /nref=136 /ntot=248 /MaxReadThrough="0.860829999999999" /MaxDrop="6.25982" /score="38.4886131" /energy="-13.4" /TU="NA" /idTUdmin="U306" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 409119..409126 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 409140..409159 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 409145 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="upshifts" S_feature 409155..409227 /Source="Nicolas_S_feature" /locus_tag="new_449651_449723" /HighExp="S0, dia5, Gly, G135, B60, T0.30H, BT, G180, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S132" CDS 409228..410664 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IICB component" /protein_id="NP_388280.2" /db_xref="EnsemblGenomes-Gn:BSU03981" /db_xref="EnsemblGenomes-Tr:CAB12206" /db_xref="GOA:P42956" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004718" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR029503" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11215" /db_xref="UniProtKB/Swiss-Prot:P42956" /translation="MQQQEQQQGGMKVKVQRFGSYLSGMIMPNIGAFIAWGIITALFI PAGWFPNEQLNTLVSPMITYLLPLLIAYTGGKMIYDHRGGVVGATAAIGVIVGSDIPM FLGAMIMGPLGGYLIKQTDKLFKDKVKQGFEMLINNFTAGIVGAALTILAFYAIGPVV LTLNKLLAAGVEVIVHANLLPVASVFVEPAKVLFLNNAINHGILSPIGIEQASQTGKS ILFLVEANPGPGLGILLAYMFFGKGSSKSTAPGAAIIHFFGGIHEIYFPYILMKPALI LAAIAGGASGLLTFTIFNAGLVAAASPGSIIALMAMTPRGGYFGVLAGVLVAAAVSFI VSAVILKSSKASEEDLAAATEKMQSMKGKKSQAAAALEAEQAKAEEASELSPESVNKI IFACDAGMGSSAMGASILRNKVKKAELDISVTNTAINNLPSDADIVITHKDLTDRAKA KLPNATHISVDNFLNSPKYDELIEKLKK*" /label="mtlA CDS" gene 409228..410664 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /label="mtlA gene" CDS 410689..411120 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IIA component" /protein_id="YP_003097678.1" /db_xref="EnsemblGenomes-Gn:BSU03982" /db_xref="EnsemblGenomes-Tr:CAX52549" /db_xref="GOA:C0H3V2" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR016152" /db_xref="UniProtKB/Swiss-Prot:C0H3V2" /translation="MQVLAKENIKLNQTVSSKEEAIKLAGQTLIDNGYVTEDYISKMF EREETSSTFMGNFIAIPHGTEEAKSEVLHSGISIIQIPEGVEYGEGNTAKVVFGIAGK NNEHLDILSNIAIICSEEENIERLISAKSEEDLIAIFNEVN*" /label="mtlF CDS" gene 410689..411120 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /label="mtlF gene" CDS 411122..412243 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /EC_number="1.1.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 22014119, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 22014119, 23279188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannitol-1-phosphate 5-dehydrogenase" /protein_id="NP_388281.2" /db_xref="EnsemblGenomes-Gn:BSU03990" /db_xref="EnsemblGenomes-Tr:CAB12207" /db_xref="GOA:P42957" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023027" /db_xref="InterPro:IPR023028" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11216" /db_xref="UniProtKB/Swiss-Prot:P42957" /translation="MIALHFGAGNIGRGFIGALLHHSGYDVVFADVNETMVSLLNEKK EYTVELAEEGRSSEIIGPVSAINSGSQTEELYRLMNEAALITTAVGPNVLKLIAPSIA EGLRRRNTANTLNIIACENMIGGSSFLKKEIYSHLTEAEQKSVSETVGFPNSAVDRIV PIQHHEDPLKVSVEPFFEWVIDESGFKGKTPVINGALFVDDLTPYIERKLFTVNTGHA VTAYVGYQRGLKTVKEAIDHPEIRRVVHSALLETGDYLVKSYGFKQTEHEQYIKKIIG RFENPFISDDVTRVARSPLRKLGENDRLVGPAKKIKEPNALAEGIAAALRFDFTGDPE AVELQALIEEKGYSGVLQEVCGIQSHEPLHAIILKKLNQ*" /label="mtlD CDS" gene 411122..412243 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /label="mtlD gene" downshifts 412226 /Source="Nicolas_upshifts" /id="D178" /incds=0 /nref=46 /ntot=156 /MaxReadThrough="5.56503" /MaxDrop="4.72154" /score="32.3837677" /energy="-13.4" /TU="U307" /idTUdmin="U308" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-35 412272..412275 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-35" promotor_-10 412291..412310 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-10" upshifts 412293 /Source="Nicolas_upshifts" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="upshifts" CDS 412334..413398 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /EC_number="1.1.1.93" /EC_number="1.1.1.83" /EC_number="4.1.1.73" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10568751, 12356321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tartrate dehydrogenase" /protein_id="NP_388282.3" /db_xref="EnsemblGenomes-Gn:BSU04000" /db_xref="EnsemblGenomes-Tr:CAB12208" /db_xref="GOA:P42958" /db_xref="InterPro:IPR011829" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG11222" /db_xref="UniProtKB/Swiss-Prot:P42958" /translation="MTMKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTA FPWSCDYYLEHGKMMPEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELE LSINMRPAKQMAGITSPLLHPNDFDFVVIRENSEGEYSEVGGRIHRGDDEIAIQNAVF TRKATERVMRFAFELAKKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQ HIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMF EPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKILDVMEQVTADGIKTRDI GGQSTTAEVTDEICSRLRKL*" /label="ycsA CDS" gene 412334..413398 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /label="ycsA gene" promotor_-35 412568..412576 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 412590..412609 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 412600 /Source="Nicolas_upshifts" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 413392 /Source="Nicolas_upshifts" /id="D179" /incds=0 /nref=7 /ntot=41 /MaxReadThrough="4.24123" /MaxDrop="4.42639" /score="9.70532694" /energy="-11.6" /TU="U307,U308" /idTUdmin="U308" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 413465..413472 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413485..413504 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 413498 /Source="Nicolas_upshifts" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 413533..414096 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11856304, 14568161" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11856304, 14568161; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388283.1" /db_xref="EnsemblGenomes-Gn:BSU04010" /db_xref="EnsemblGenomes-Tr:CAB12209" /db_xref="GOA:P42959" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11223" /db_xref="UniProtKB/Swiss-Prot:P42959" /translation="MNAKTITLKKKRKIKTIVVLSIIMIAALIFTIRLVFYKPFLIEG SSMAPTLKDSERILVDKAVKWTGGFHRGDIIVIHDKKSGRSFVKRLIGLPGDSIKMKN DQLYINDKKVEEPYLKEYKQEVKESGVTLTGDFEVEVPSGKYFVMGDNRLNSLDSRNG MGMPSEDDIIGTESLVFYPFGEMRQAK*" /label="sipU CDS" gene 413533..414096 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /label="sipU gene" S_feature 414097..414821 /Source="Nicolas_S_feature" /locus_tag="new_454593_455317" /HighExp="G150, Oxctl, Lbexp, G135, Paraq, dia0, LBGexp, Mt0, G180, dia15" /AntisenseName="yczH" /AntisenseCor="0.134432865921808" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S133" CDS complement(414156..414764) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388284.2" /db_xref="EnsemblGenomes-Gn:BSU04020" /db_xref="EnsemblGenomes-Tr:CAB12210" /db_xref="GOA:O31482" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12782" /db_xref="UniProtKB/Swiss-Prot:O31482" /translation="MFPKPLVILAHEIYGVNSHMKKMGRLIKMAGYDVLTPNLLGEDE VYTLKEEKTAYEQFTKHERLKTGETIIQNVIRQNAGRHIFVIGFSVGATIAWKCSSMP EVSGSVCYYGSRIRDSLHHMPACPVLLFFPNYEPSFDVALLIKKLREKQHTHLEIYQF DALHGFANPDSVYFNRALFFKTLSIIKNGAESRLRTVSSSFF*" /label="yczH CDS" gene complement(414156..414764) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /label="yczH gene" misc_feature complement(414782..414801) /Source="Nicolas_upshift_promotors" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 414798..414804 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(414805) /Source="Nicolas_upshifts" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 414817..414836 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 414823 /Source="Nicolas_upshifts" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 414850..415242 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16291680, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacyl-(acyl carrier protein) dehydratase" /protein_id="NP_388285.2" /db_xref="EnsemblGenomes-Gn:BSU04030" /db_xref="EnsemblGenomes-Tr:CAB12211" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11225" /db_xref="UniProtKB/Swiss-Prot:P42961" /translation="MNSLSLPHRYPFLFIDGVTDSEPGKHAAAYKLISENDWFITDTQ TEMPFSLVIEALAQTAAFTGITDENSLGLLSSVKKAEKLGEAVPGDRLDLTFEVTRNR RGFVFGHAKASVGEQPVAEAEIGIYIEK*" /label="ycsD CDS" gene 414850..415242 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /label="ycsD gene" downshifts 415219 /Source="Nicolas_upshifts" /id="D180" /incds=0 /nref=23 /ntot=189 /MaxReadThrough="1.8721" /MaxDrop="3.42324" /score="-5.4921522" /energy="-13.6" /TU="NA" /idTUdmin="U310" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(415275..415439) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097679.1" /db_xref="EnsemblGenomes-Gn:BSU04039" /db_xref="EnsemblGenomes-Tr:CAX52550" /db_xref="UniProtKB/Swiss-Prot:C0H3V3" /translation="MTEKKQQNKPNENPEHNDLTDPIPNEELKENMNDEKHKRQQRDN SQSERDYDTK*" /label="yczO CDS" gene complement(415275..415439) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /label="yczO gene" downshifts complement(415295) /Source="Nicolas_upshifts" /id="D181" /incds=0 /nref=101 /ntot=193 /MaxReadThrough="1.44096" /MaxDrop="6.55741" /score="22.582242" /energy="-10.6" /TU="NA" /idTUdmin="U313" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(415449..415467) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(415471) /Source="Nicolas_upshifts" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(415482..415488) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 415501..415508 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 415522..415541 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 415525 /Source="Nicolas_upshifts" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="upshifts" CDS 415572..416321 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208, 27435445, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase / 5' nucleotidase" /protein_id="NP_388286.2" /db_xref="EnsemblGenomes-Gn:BSU04040" /db_xref="EnsemblGenomes-Tr:CAB12212" /db_xref="GOA:P42962" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11226" /db_xref="UniProtKB/Swiss-Prot:P42962" /translation="MSVQREDVDIKLIAIDMDGTLLNDEQLISDENRKAIREAEDKGV YVVISTGRTLMTCRELAESLKLSSFLITANGSEIWDSNFNLVERKLLHTDHIQMMWDL RNKHNTNFWASTVNKVWRGEFPENITDHEWLKFGFDIEDDDIRNEVLEELRKNKELEI TNSSPTNIEVNALGINKAAALAKVTEKLGFTMENVMAMGDSLNDIAMIKEAGLGVAMG NAQDIVKETADYITDTNIEDGVAKAIRHWVL*" /label="ribZ CDS" gene 415572..416321 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /label="ribZ gene" downshifts 416298 /Source="Nicolas_upshifts" /id="D182" /incds=0 /nref=219 /ntot=253 /MaxReadThrough="3.23506" /MaxDrop="6.84998" /score="19.5535298" /energy="-11.7" /TU="NA" /idTUdmin="U314" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(416374) /Source="Nicolas_upshifts" /id="D183" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="0.52326" /MaxDrop="2.84763" /score="25.9755124" /energy="-11.7" /TU="NA" /idTUdmin="U313" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" promotor_-35 416404..416410 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 416424..416443 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 416430..416526 /Source="Nicolas_S_feature" /locus_tag="new_456926_457022" /HighExp="S1, Cold, S0, GM 5, BMM, MG 25, Lbtran, aero, GM 10, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S134" upshifts 416430 /Source="Nicolas_upshifts" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 416527..417300 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxoprolinase subunit A" /protein_id="NP_388287.3" /db_xref="EnsemblGenomes-Gn:BSU04050" /db_xref="EnsemblGenomes-Tr:CAB12213" /db_xref="GOA:P42963" /db_xref="InterPro:IPR005501" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG11227" /db_xref="UniProtKB/Swiss-Prot:P42963" /translation="MFQIDLNCDLGESFGAYKIGLDQDILEYVTSANIACGFHAGDPS VMRKTVALAAERGVKMGAHPGLPDLLGFGRRNMAISPEEAYDLVVYQIGALSGFLKAE GLHMQHVKPHGALYNMAAVDQKLSDAIAKAVYKVDPGLILFGLAESELVKAGERIGLQ TANEVFADRTYQSDGTLTPRSQPDALIESDDAAVTQVIKMVKEGAVKSQQGHDVSLKA DTVCIHGDGAHALTFAQKIRKQLKAAGIEVTAISEQRST*" /label="pxpA CDS" gene 416527..417300 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /label="pxpA gene" CDS 417315..418529 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9334321, 15849754, 16850406, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-oxoproline transporter" /protein_id="NP_388288.3" /db_xref="EnsemblGenomes-Gn:BSU04060" /db_xref="EnsemblGenomes-Tr:CAB12214" /db_xref="GOA:P42964" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG11228" /db_xref="UniProtKB/Swiss-Prot:P42964" /translation="MEQQKKTAGKKAGSWSLLMGAAFLMATSAIGPGFLTQTATFTNT LAASFGFVILISIILDIFAQTNVWRIIAVSGKRGQEIANMVLPGLGYFIAILVVLGGL AFNIGNIGGAGLGLQVLFGITPETGALISAVIAILIFVIKEAGKAMDRFTQIAGFVMI ILTVYVAATTAPPVGQAVANTFVPEHISIFAIVTLVGGTVGGYITFAGGHRLLDAGIK GKESIPQVTKSSVVGILITSVMRIALFLAVLGVVSKGLHIDESNPAASVFKLAAGNVG YKIFGLIMWSAAITSVIGAAYTSVSFFKTFSPKIEKNSRGIIIGFIVVSTLAFVTIGQ PAKILVLVGSLNGLILPIALGTLLVAAYKKNIVGDYKHPLWLTSTGALVVIVMAVMGI YTLCTQLPQLWS*" /label="pxpG CDS" gene 417315..418529 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /label="pxpG gene" CDS 418553..419326 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8186229, 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative D-5-oxoproline epimerase" /protein_id="NP_388289.3" /db_xref="EnsemblGenomes-Gn:BSU04070" /db_xref="EnsemblGenomes-Tr:CAB12215" /db_xref="GOA:P42966" /db_xref="InterPro:IPR009906" /db_xref="InterPro:IPR016938" /db_xref="SubtiList:BG11230" /db_xref="UniProtKB/Swiss-Prot:P42966" /translation="MAPKDVRALIREGKINGPTAGMSGGYAQANLVVLKKDLAFDFLL FCQRNQKPCPVLDVTEAGSPVPSLAAPDADIRTDFPKYRIYRHGILTEEVSDITPYWE DDFVGFLIGCSFSFEQALINNGIAVRHIDEGTNVSMYKTNIDCVPAGAFHGQMVVSMR PVPERLAVRAAQVTSRFPAVHGGPIHIGNPGAIGIRDLGKPDFGDAVSIRDGEVPVFW ACGVTPQAVAMNVKPEMVITHAPGHMLITDIRDESLAVL*" /label="pxpI CDS" gene 418553..419326 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /label="pxpI gene" CDS 419371..420093 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /EC_number="3.5.2.9" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit B" /protein_id="NP_388290.2" /db_xref="EnsemblGenomes-Gn:BSU04080" /db_xref="EnsemblGenomes-Tr:CAB12216" /db_xref="GOA:P60495" /db_xref="InterPro:IPR003833" /db_xref="InterPro:IPR010016" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR029000" /db_xref="PDB:2KWA" /db_xref="PDB:2ZP2" /db_xref="SubtiList:BG11231" /db_xref="UniProtKB/Swiss-Prot:P60495" /translation="MTVRYQIEQLGDSAMMIRFGEEINEQVNGIVHAAAAYIEEQPFP GFIECIPAFTSLTVFYDMYEVYKHLPQGISSPFESVKRDVEERLAEIAEDYEVNRRIV EIPVCYGGEFGPDLEEVAKINQLSPEEVIDIHTNGEYVVYMLGFAPGFPFLGGMSKRI AAPRKSSPRPSIPAGSVGIAGLQTGVYPISTPGGWQLIGKTPLALFRPQENPPTLLRA GDIVKFVRISEKDYHAYKEESN*" /label="pxpB CDS" gene 419371..420093 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /label="pxpB gene" CDS 420096..421103 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit C" /protein_id="YP_054571.2" /db_xref="EnsemblGenomes-Gn:BSU04090" /db_xref="EnsemblGenomes-Tr:CAE01447" /db_xref="GOA:Q7WY77" /db_xref="InterPro:IPR003778" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG14193" /db_xref="UniProtKB/Swiss-Prot:Q7WY77" /translation="MKVLKPGLLTTVQDIGRTGYQKYGVLASGAMDTVSLRIANLLIG NGENEAGLEITMMGPGPSFHFSKQTLIAVTGADFTLRINDEEAPLWKPVLIKENSTVS FGPCKLGSRAYLAAAGGIEVPAVMESKSTYVRGSIGGLHGRALQKEDELNIGEMSALS QTILSRLSSQLGKQGFAAPKWSVSRGRFLPLKKNPVIRVLEGKQFAFFTEESKTRFYE EAFRVTPQSDRMGYRLKGEPLELKAPLEMVSEAVSFGTVQVPPDGNPIILLADRQTTG GYPRIAHIISADLPIVSQIMPGEHVQFEPVSLQEAEALAVEREQHIKELKTRMKMEWL T*" /label="pxpC CDS" gene 420096..421103 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /label="pxpC gene" downshifts 420589 /Source="Nicolas_upshifts" /id="D184" /incds=1 /nref=6 /ntot=27 /MaxReadThrough="5.04721" /MaxDrop="4.5277" /score="-7.2426149" /energy="-12.4" /TU="U315" /idTUdmin="U315" /TUdmin="-1975" /isTUend="FALSE" /label="downshifts" promotor_no_box 420683..420783 /Source="Nicolas_upshift_promotors" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 420743 /Source="Nicolas_upshifts" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 421119..421871 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9334321; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the pxp operon (IclR family)" /protein_id="NP_388291.2" /db_xref="EnsemblGenomes-Gn:BSU04100" /db_xref="EnsemblGenomes-Tr:CAB12217" /db_xref="GOA:P42968" /db_xref="InterPro:IPR005471" /db_xref="InterPro:IPR014757" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11214" /db_xref="UniProtKB/Swiss-Prot:P42968" /translation="MQNKNKTVVKSMALLNLFLHKPSLTLSELVSLTGMPKTSVHRMV SSLEEMGFLSRDASGAYSLGLVFLEFGQLVADRLDIRKIAKPVMEELCREVDEAVQLI MRDGNEAIYVEKIEGTQTVRLYTAIGRRSPLYAGACARSILSFLPREEIEAYIKQTEL ISIGSGTITDPEKLLQEIDASVQNGYTVSYSELENYTAAIGAPIFNHERQVAAGISIA GFEARFTEDRLPYLTEKVKDAALQISRKIGYT*" /label="pxpR CDS" gene 421119..421871 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /label="pxpR gene" promotor_-35 421869..421878 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 421892..421911 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 421902 /Source="Nicolas_upshifts" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 421935..422576 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /EC_number="3.1.1.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 17220230, 20057119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 17220230, 20057119; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat phospholipase B" /protein_id="NP_388292.1" /db_xref="EnsemblGenomes-Gn:BSU04110" /db_xref="EnsemblGenomes-Tr:CAB12218" /db_xref="GOA:P42969" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11232" /db_xref="UniProtKB/Swiss-Prot:P42969" /translation="MVLRYTALGDSLTTGRGSGLFSPGFVQRFGDMMEADLKTRTAIN IFARSGLNTEEILGLLSYPYVQKCIRDADMITITGCGNDLIDSVLAYQTSKDETIFSR VSAHCHENFEKMIAKVAEIKGENPSPYAIRVFNLYNPFPEIDIAGKWITSFNSHLETL ASAPHVKIADAYSIFKGKEQEYLSFDGVHPNSKGYQAMAEAVHKLGYKELSVS*" /label="lipC CDS" gene 421935..422576 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /label="lipC gene" downshifts 422562 /Source="Nicolas_upshifts" /id="D185" /incds=0 /nref=106 /ntot=223 /MaxReadThrough="0.550230000000001" /MaxDrop="6.63515" /score="26.7371783" /energy="-11.8" /TU="NA" /idTUdmin="U315" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(422574..422999) /Source="Nicolas_S_feature" /locus_tag="new_463070_463495_c" /HighExp="S1, Sw, BC, S2, Lbtran, M0t90, LPhT, BI, M40t45, C90" /AntisenseName="yczI" /AntisenseCor="-0.57558682544748696" /AntisenseRegPval="-24.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S135" downshifts complement(422619) /Source="Nicolas_upshifts" /id="D186" /incds=0 /nref=171 /ntot=252 /MaxReadThrough="1.91715" /MaxDrop="5.13764" /score="6.4765859" /energy="-11.8" /TU="NA" /idTUdmin="U319" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 422652..422658 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 422672..422691 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 422673 /Source="Nicolas_upshifts" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="upshifts" CDS 422749..422994 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388293.1" /db_xref="EnsemblGenomes-Gn:BSU04120" /db_xref="EnsemblGenomes-Tr:CAB12219" /db_xref="GOA:P42970" /db_xref="InterPro:IPR025018" /db_xref="SubtiList:BG12783" /db_xref="UniProtKB/Swiss-Prot:P42970" /translation="MFRIFKMSFAVIIIILALIAFNYTEHTSVIQSVMLVFLGAVMFM QGLEERKKENDGSGAFNIYTAVFVWSVSLIGFTLHII*" /label="yczI CDS" gene 422749..422994 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /label="yczI gene" S_feature 422995..423405 /Source="Nicolas_S_feature" /locus_tag="new_463491_463901" /HighExp="T5.0H, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, M9-stat, T-4.40H, T-3.40H" /AntisenseName="yczJ" /AntisenseCor="-0.20847541933848601" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S136" CDS complement(423000..423287) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388294.1" /db_xref="EnsemblGenomes-Gn:BSU04130" /db_xref="EnsemblGenomes-Tr:CAB12220" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12784" /db_xref="UniProtKB/Swiss-Prot:O31484" /translation="MVREAAMLHIKEGLEQEFEDAFRQAAPIISGMKGYITHSLSKCM EETHKYLLLVEWETLEDHTEGFRGSSEYQEWKALLHRFYTPFPTVEHFQDV*" /label="yczJ CDS" gene complement(423000..423287) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /label="yczJ gene" misc_feature complement(423308..423327) /Source="Nicolas_upshift_promotors" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(423324) /Source="Nicolas_upshifts" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 423381..423385 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 423402..423421 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 423407 /Source="Nicolas_upshifts" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 423438..425444 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8830698, 10648534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830698, 10648534; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="penicillin-binding lipoprotein 3; transpeptidase" /protein_id="NP_388295.1" /db_xref="EnsemblGenomes-Gn:BSU04140" /db_xref="EnsemblGenomes-Tr:CAB12221" /db_xref="GOA:P42971" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR007887" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR032710" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11234" /db_xref="UniProtKB/Swiss-Prot:P42971" /translation="MLKKCILLVFLCVGLIGLIGCSKTDSPEDRMEAFVKQWNDQQFD DMYQSLTKDVKKEISKKDFVNRYKAIYEQAGVKNLKVTAGEVDKDDQDNKTMKHIPYK VSMNTNAGKVSFKNTAVLKLEKTDDEESWNIDWDPSFIFKQLADDKTVQIMSIEPKRG QIYDKNGKGLAVNTDVPEIGIVPGELGDKKEKVIKELAKKLDLTEDDIKKKLDQGWVK DDSFVPLKKVKPDQEKLVSEATSLQGVTRTNVSSRYYPYGEKTAHLTGYVRAITAEEL KKKKEGTYSDTSNIGIAGLENVYEDKLRGTTGWKIYVPQTGEVIAEKKAKDGEDLHLT IDIKTQMKLYDELKDDSGAAVALQPKTGETLALVSAPSYDPNGFIFGWSDKEWKKLNK DKNNPFSAKFNKTYAPGSTIKPIAAAIGIKNGTLKADEKKTIKGKEWQKDSSWGGYSV TRVSERLQQVDLENALITSDNIYFAQNALDMGADTFTKGLKTFGFSEDVPYEFPIQKS SIANDKLDSDILLADTGYGQGQMQMSPLHLATAYTPFVDNGDLVKPTLIKKDSQTADV WHKQVVTKEGAADITKGLKGVVEDERGSAYQPVVKGITVAGKTGTAELKTSKDDKDGT ENGWFVGYDYENKDLLVAMMIQNVQDRGGSHYVVEKAKKQFQSN*" /label="pbpC CDS" gene 423438..425444 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /label="pbpC gene" S_feature 425445..425545 /Source="Nicolas_S_feature" /locus_tag="new_465941_466041" /HighExp="LBGstat, T5.0H, M0t45, T3.30H, S0, LBGtran, Oxctl, T4.0H, C30, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.946, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S137" CDS 425546..426448 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388296.1" /db_xref="EnsemblGenomes-Gn:BSU04150" /db_xref="EnsemblGenomes-Tr:CAB12222" /db_xref="GOA:P42972" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11235" /db_xref="UniProtKB/Swiss-Prot:P42972" /translation="MQRIQLAEDLQFSRVIHGLWRLNEWNYSDAELLSLIEWCIDHGI TTFDHADIYGGYTCEKLFGNALALSPGLRENIELVTKCGIVLESPERPAHRSHHYNTS KSHILASVEQSLMNLRTDYIDMLLIHRPDPLMDPEGVAEAFQALKCSGKVRYFGVSNF KDHQYRMLESYLPEKLVTNQIELSAYELENMLDGTLNLCQEKRIPPMAWSPLAGGKVF TENTDKDRRVRTALESVQGEIGAASLDEVMYAWLYTHPAGIMPIVGSGKRERISAAIN ALSYKLDQDQWFRIFTAVQGYDIP*" /label="ycsN CDS" gene 425546..426448 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /label="ycsN gene" downshifts 426428 /Source="Nicolas_upshifts" /id="D187" /incds=0 /nref=48 /ntot=206 /MaxReadThrough="3.20352" /MaxDrop="4.57855" /score="1.36962171" /energy="-10.6" /TU="U320" /idTUdmin="U318" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 426521..426528 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 426542..426561 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 426546..426633 /Source="Nicolas_S_feature" /locus_tag="new_467042_467129" /HighExp="S0, Gly, BC, Lbstat, S2, M9-stat, G135, dia5, T0.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S138" upshifts 426546 /Source="Nicolas_upshifts" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 426634..428718 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188, 24196428, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188, 24196428, 26159071; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, PTS-dependent activator" /protein_id="NP_388297.1" /db_xref="EnsemblGenomes-Gn:BSU04160" /db_xref="EnsemblGenomes-Tr:CAB12223" /db_xref="GOA:P96574" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG12049" /db_xref="UniProtKB/Swiss-Prot:P96574" /translation="MYMTAREQKLLKHLLLQNRYITVTELAELMQVSTRTIHRELKSI KPLMETVGLTLDKQPGKGLKAVGSPEGKQKLLTDLSYEQHEYSADERKLLILCSLLES QEPVKLYTLAHDLQVTNATVSYDLDELEKWISPFGLTLIRKRGFGIQLIGPENAKRKI VGNLIVNRLDIQMFLEAVELNIKGKTDSSEKMFGVVSKGELLKMERILFQLKEKIAFS LSDSSYIALVVHLTYAIERIKLGETITMEQNELEELMNAKEYSSALEIAGELERAFGV TIPEAEVGYITIHLRSANRKYKTEYKAQEIELETALQTKRLIAFISDKIRMDLTKNYS LYEGLIAHLEPAVSRIKENIEIYNPMKEQIKRDYFLLYMAIEEGVEKYFPGMSFSDDE IAFIVLHFGSALEIKKEEAKVKALVVCSSGIGSSKMLASRLKKELPEIESFDMSSLIE LKGKDVQAYDMIVSTVPIPYENIDYIMVSPLLNEEDANQVKQYIKRKIPLILNKKRSS KEEAQQADVPDMLEAAESIGRYMEVIQDVLRHFTLAQLKTNPDHSMLLLELFQQLKKD GLIRDPEKAAVCLAEREKQGGLGIPGTNMALYHLKNDEIVLPFFKMFDLSTPYEVDGM DGNTLRMTRILVMMAPGSLSAEGSEILSAISSAIIESGESMAGFQEEGGQELYQRLNR IFFTWMKEKNIL*" /label="mtlR CDS" gene 426634..428718 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /label="mtlR gene" downshifts 428705 /Source="Nicolas_upshifts" /id="D188" /incds=0 /nref=107 /ntot=220 /MaxReadThrough="1.91059" /MaxDrop="5.63565" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U321" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 428747..428753 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 428767..428785 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 428779 /Source="Nicolas_upshifts" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="upshifts" S_feature 428790..428871 /Source="Nicolas_S_feature" /locus_tag="new_469286_469367" /HighExp="Etha, S5, S6, ferm, S8, nit, S7, BT, Salt, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S139" promotor_-35 428833..428840 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 428854..428873 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 428873 /Source="Nicolas_upshifts" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="upshifts" CDS 428930..430441 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA ligase" /protein_id="NP_388298.2" /db_xref="EnsemblGenomes-Gn:BSU04170" /db_xref="EnsemblGenomes-Tr:CAB12224" /db_xref="GOA:P96575" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG12050" /db_xref="UniProtKB/Swiss-Prot:P96575" /translation="METLQHLILHDMPNSEEIEAVKSGDHTLTYKGYRKRINQLANAM LQKGIQKGDRVALLCKNGHPASTVMFAALEIGAVVVPVSWQLKPYEMTGILKASEPKA MFYGAEFKEILDEVLPELSSLCVTMETGTAYETSAEFEALFAGPDHLPETEMVSPDDT ALLMFTSGTTGNPKRCMITHGGIYRYVKKSNSSIARMKGLRFLACHPIYHTSALICIM LGTFAETTFVFTKDQDPVHMLKVIEEEKIQTVMALPVFYTYLLEAWEKHQTDLSSLVI LMTGGTKVPSSLISRYLDIGIPLAHGYGSTEAWGISTWTPDMGMDKAASAGKPVAGVK VKVEDPLTGEELPQGEIGEIVVHTPFLFKGYEDNPEATAKVLQNGWFRTGDSGYVDED GFIFITGRYKDVIIYGGDNVYPDQVEEVIQQIPGILETAVVGIPDPLYGEKPKAFIVK NGGQRITEEDVIAFCKERLSAYKIPEVEFVNELPKNNLGKVKKDVLRNQAVHS*" /label="ydaB CDS" gene 428930..430441 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /label="ydaB gene" downshifts 430425 /Source="Nicolas_upshifts" /id="D189" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.57376" /MaxDrop="3.70168" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U323" /TUdmin=73 /isTUend="FALSE" /label="downshifts" CDS complement(430461..431006) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388299.1" /db_xref="EnsemblGenomes-Gn:BSU04180" /db_xref="EnsemblGenomes-Tr:CAB12225" /db_xref="GOA:P96576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12051" /db_xref="UniProtKB/Swiss-Prot:P96576" /translation="MIAGYIMAAENQTLNQWTINQLGITRGDSILEVGFGPGYCMQQM LKREKDVHLHGIDVSEAMLKLAARRVKPKGVRLIQGSIETFPLPASFYDKVISVNNYT IWNDQTKGIKQIYRALKPGGKAAITMQPREADASPEKTKSFGRQMIADFKAAGFEDID IQFKNIKPELSVCATAKKPAT*" /label="ydaC CDS" gene complement(430461..431006) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /label="ydaC gene" downshifts complement(430494) /Source="Nicolas_upshifts" /id="D190" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="1.44039" /MaxDrop="3.73662" /score="-9.35066962" /energy="-11.5" /TU="NA" /idTUdmin="U324" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(431073..431091) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(431087) /Source="Nicolas_upshifts" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(431106..431112) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 431148..431154 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-35" upshifts 431166 /Source="Nicolas_upshifts" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="upshifts" promotor_-10 431169..431187 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-10" CDS 431213..432073 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528, 21520290, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_388300.1" /db_xref="EnsemblGenomes-Gn:BSU04190" /db_xref="EnsemblGenomes-Tr:CAB12226" /db_xref="GOA:P80873" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12052" /db_xref="UniProtKB/Swiss-Prot:P80873" /translation="MANYPKELPAQTQSRQPGIESEMNPSPVYEYEDYKGADKLKGKV ALITGGDSGIGRAVSVAYAKEGADIAIVYKDEHEDAEETKKRVEQEGVKCLLIAGDVG EEEFCNEAVEKTVKELGGLDILVNNAGEQHPKESIKDITSEQLHRTFKTNFYSQFYLT KKAIDYLKPGSAIINTTSINPYVGNPTLIDYTATKGAINAFTRTMAQALVKDGIRVNA VAPGPIWTPLIPATFPEETVAQFGQDTPMGRPGQPVEHVGCYVLLASDESSYMTGQTL HVNGGNFVTT*" /label="ydaD CDS" gene 431213..432073 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /label="ydaD gene" CDS 432089..432592 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /EC_number="5.3.1.15" /experiment="publication(s) with functional evidences, PMID:10220166, 15805528, 21421786, 21520290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15805528, 21421786, 21520290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lyxose ketol isomerase" /protein_id="NP_388301.1" /db_xref="EnsemblGenomes-Gn:BSU04200" /db_xref="EnsemblGenomes-Tr:CAB12227" /db_xref="GOA:P96578" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:2Y0O" /db_xref="SubtiList:BG12053" /db_xref="UniProtKB/Swiss-Prot:P96578" /translation="MGITKEEVNSYYQKAGIVLTDEEVDQIQLMDYGLGKERKVGLQL FVYVNTDRYCSKELVLFPGQTCPEHRHPPVDGQEGKQETFRCRYGKVYLYVEGEKTPL PKVLPPQEDREHYTVWHEIELEPGGQYTIPPNTKHWFQAGEEGAVVTEMSSTSTDKHD IFTDPRI*" /label="lyxE CDS" gene 432089..432592 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /label="lyxE gene" downshifts 432573 /Source="Nicolas_upshifts" /id="D191" /incds=0 /nref=16 /ntot=26 /MaxReadThrough="4.81615" /MaxDrop="6.21035" /score="29.8440619" /energy="-15.5" /TU="U325" /idTUdmin="U325" /TUdmin="-683" /isTUend="FALSE" /label="downshifts" promotor_-35 432621..432628 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 432642..432661 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 432644 /Source="Nicolas_upshifts" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 432678..433229 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /EC_number="2.3.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15468321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal protein N-acetyltransferase" /protein_id="NP_388302.1" /db_xref="EnsemblGenomes-Gn:BSU04210" /db_xref="EnsemblGenomes-Tr:CAB12228" /db_xref="GOA:P96579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1NSL" /db_xref="SubtiList:BG12054" /db_xref="UniProtKB/Swiss-Prot:P96579" /translation="MFTCKVNEHITIRLLEPKDAERLAELIIQNQQRLGKWLFFAENP SSADTYRETIIPDWRRQYADLNGIEAGLLYDGSLCGMISLHNLDQVNRKAEIGYWIAK EFEGKGIITAACRKLITYAFEELELNRVAICAAVGNEKSRAVPERIGFLEEGKARDGL YVNGMHHDLVYYSLLKREWEGEK*" /label="ydaF CDS" gene 432678..433229 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /label="ydaF gene" promotor_-35 433244..433250 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 433265..433283 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 433278 /Source="Nicolas_upshifts" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 433307..433729 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_388303.1" /db_xref="EnsemblGenomes-Gn:BSU04220" /db_xref="EnsemblGenomes-Tr:CAB12229" /db_xref="GOA:P80238" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG19017" /db_xref="UniProtKB/Swiss-Prot:P80238" /translation="MNQQDIKQKVLDVLDHHKVGSLATVQKGKPHSRYMTFFHDGLTI YTPTSKETHKAEEIENNPNVHILLGYDCEGFGDAYVEVAGKAKINNSAELKDKIWSSK LERWFDGKDDPNLVILEIEPEDIRLMNAGEKTPVSLEL*" /label="ydaG CDS" gene 433307..433729 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /label="ydaG gene" promotor_-35 433734..433742 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 433753..433772 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 433772..434138 /Source="Nicolas_S_feature" /locus_tag="new_474268_474634" /HighExp="Etha, Salt, Cold, Sw, B60, Gly, M9-stat, LPhT, B36, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.999, 1" /TUlongSig="SigB" /TUlongPSig=1 /label="S140" upshifts 433772 /Source="Nicolas_upshifts" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(433798..433898) /Source="Nicolas_upshift_promotors" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" misc_RNA complement(433833..434101) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /product="small regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 23457461" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23457461; Product type n: RNA" /label="bsrC RNA" gene complement(433833..434101) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /label="bsrC gene" upshifts complement(433838) /Source="Nicolas_upshifts" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 434095 /Source="Nicolas_upshifts" /id="D192" /incds=0 /nref=124 /ntot=275 /MaxReadThrough="2.67264" /MaxDrop="7.35087" /score="29.9942993" /energy="-12" /TU="NA" /idTUdmin="U326" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 434175..434184 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 434197..434212 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 434202 /Source="Nicolas_upshifts" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 434235..435044 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_388304.1" /db_xref="EnsemblGenomes-Gn:BSU04230" /db_xref="EnsemblGenomes-Tr:CAB12230" /db_xref="GOA:P96581" /db_xref="InterPro:IPR021260" /db_xref="SubtiList:BG12055" /db_xref="UniProtKB/Swiss-Prot:P96581" /translation="MHVITTQVLFIFCFLLLIHSIETLAYATRLSGARVGFIASALSL FNVMVIVSRMSNMVQQPFTGHLIDDAGKNALAIVGEQFRFLIFGSTVGTILGIILLPS FVALFSRAIIHLAGGGGSVFQVFRKGFSKQGFKNALSYLRLPSISYVKGFHMRLIPKR LFVINMLITSIYTIGVLSALYAGLLAPERSTTAVMASGLINGIATMLLAIFVDPKVSV LADDVAKGKRSYIYLKWTSVTMVTSRVAGTLLAQLMFIPGAYYIAWLTKWF*" /label="amj CDS" gene 434235..435044 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /label="amj gene" downshifts 435025 /Source="Nicolas_upshifts" /id="D193" /incds=0 /nref=5 /ntot=103 /MaxReadThrough="2.92236" /MaxDrop="3.54247" /score="15.7032536" /energy="-14.9" /TU="U330" /idTUdmin="U327" /TUdmin=911 /isTUend="FALSE" /label="downshifts" CDS complement(435088..435378) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388305.1" /db_xref="EnsemblGenomes-Gn:BSU04240" /db_xref="EnsemblGenomes-Tr:CAB12231" /db_xref="GOA:O31485" /db_xref="InterPro:IPR023845" /db_xref="SubtiList:BG12807" /db_xref="UniProtKB/Swiss-Prot:O31485" /translation="MLHTPIGRLRTMGFIEGMSLLILLFIAMPLKYWAGLPLAVTIVG SVHGGLFILYLLVLAYATFSVKWPLKWSAAGFIAAFVPFGNFLYDRGLRNYK*" /label="ydzA CDS" gene complement(435088..435378) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /label="ydzA gene" downshifts complement(435092) /Source="Nicolas_upshifts" /id="D194" /incds=0 /nref=235 /ntot=260 /MaxReadThrough="1.23465" /MaxDrop="7.74945" /score="10.1798531" /energy="-14.9" /TU="NA" /idTUdmin="U332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(435406..435425) /Source="Nicolas_upshift_promotors" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 435406..435424 /Source="Nicolas_upshift_promotors" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 435412 /Source="Nicolas_upshifts" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(435422) /Source="Nicolas_upshifts" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 435500..435507 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 435521..435540 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 435525 /Source="Nicolas_upshifts" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 435563..435997 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9341680, 10606655, 10913073, 12458218, 16407330, 16528101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341680, 10606655, 10913073, 12458218, 16407330, 16528101; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388306.1" /db_xref="EnsemblGenomes-Gn:BSU04250" /db_xref="EnsemblGenomes-Tr:CAB12232" /db_xref="GOA:P96582" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2CFX" /db_xref="SubtiList:BG12056" /db_xref="UniProtKB/Swiss-Prot:P96582" /translation="MKLDQIDLNIIEELKKDSRLSMRELGRKIKLSPPSVTERVRQLE SFGIIKQYTLEVDQKKLGLPVSCIVEATVKNADYERFKSYIQTLPNIEFCYRIAGAAC YMLKINAESLEAVEDFINKTSPYAQTVTHVIFSEIDTKNGRG*" /label="lrpC CDS" gene 435563..435997 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /label="lrpC gene" promotor_-35 435994..435997 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 436006 /Source="Nicolas_upshifts" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 436014..436033 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 436062..438245 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /EC_number="5.99.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16192570, 16556226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase III" /protein_id="NP_388307.1" /db_xref="EnsemblGenomes-Gn:BSU04260" /db_xref="EnsemblGenomes-Tr:CAB12233" /db_xref="GOA:P96583" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005738" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR034144" /db_xref="SubtiList:BG11979" /db_xref="UniProtKB/Swiss-Prot:P96583" /translation="MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGH LVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVI ATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSA VARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIR AAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDL TELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGME VKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIA KRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQEDDRDQ TLPALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGE TGGLGTVATRADIIEKLFNSFLIEKKGQDIFITSKGKQLLQLVPEDLKSPALTAEWEQ KLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSSQTFRHDNITGTACPECGKMMLKVN GKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRMELRGQGEGQTFACVCGHREKLSV FEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQLKKLGLDK*" /label="topB CDS" gene 436062..438245 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /label="topB gene" downshifts 438228 /Source="Nicolas_upshifts" /id="D195" /incds=0 /nref=133 /ntot=245 /MaxReadThrough="3.22367" /MaxDrop="6.18597" /score="23.5229393" /energy="-10.4" /TU="U334" /idTUdmin="U333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 438294..438300 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 438315..438333 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 438316..438447 /Source="Nicolas_S_feature" /locus_tag="new_478812_478943" /HighExp="Etha, Salt, Heat, Cold, H2O2, G180, LPhT, Oxctl, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S141" upshifts 438316 /Source="Nicolas_upshifts" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="upshifts" CDS 438448..439536 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 26078454, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 26078454, 27897378; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="glycosyl hydrolase lipoprotein" /protein_id="NP_388308.1" /db_xref="EnsemblGenomes-Gn:BSU04270" /db_xref="EnsemblGenomes-Tr:CAB12234" /db_xref="GOA:O31486" /db_xref="InterPro:IPR008928" /db_xref="SubtiList:BG12057" /db_xref="UniProtKB/Swiss-Prot:O31486" /translation="MRHVLIAVILFFLSIGLSAGCAEAGNKTQNQSATEVNASPLQPA EYFIYHNLMNDKGLIKTDFSDQPSYLSESLGLWMEFLLSKNDAPHFQDQYQHLTDSFL MSNHLVTWKIQNGQASGTNALIDDMRIMLSLDQAAAKWGRSDYAQTARDIGTSLKTYN MNNGFFTDFYDSQAASKDVTLSYVMPDALAVLKKNGIIDEETEQRNANVLYSAPLKNG FLPKTYSSETKEYTYDSEINLIDQLYAAWHLPEGDEKASVLADWIKQEFQKNGKLYGR YSAYTKEPAVQYESPSVYALAVLFLTKQHENSSVIKAIYDRMNDFEIHDPVKSYYGGY MSGTQTHSFDNLLPLLAERKLFNENIIQ*" /label="epsJ CDS" gene 438448..439536 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /label="epsJ gene" CDS 439517..440368 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23893111, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111, 27897378; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic-di-GMP receptor" /protein_id="NP_388309.1" /db_xref="EnsemblGenomes-Gn:BSU04280" /db_xref="EnsemblGenomes-Tr:CAB12235" /db_xref="GOA:P96585" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG12058" /db_xref="UniProtKB/Swiss-Prot:P96585" /translation="MKISFSESQKLFAYFSGLIAALSLFIYYVSAQQSEGALILCITF GVIAAGIWFGPIYALAVTLIVLFVLGTLMMFFQTGQTSLFPAEEGLRMLVVWGIALLL FSFISGRIHDITAELRRSMTRLQSEIKSYVAVDRVTGFDNKQRMKLELSEEIKRAERY GNSFVFLLLHMHYFKEFKSLYGEKETDRLFQYVGQQIRTSVRETDKKFRPSDERIGIV LTHTPAEHMPAVLTKLKKQLDTYQLENGKYVSLTFHVCYLPYRNDIQTADQFLEELEN EMMMNEL*" /label="epsK CDS" gene 439517..440368 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /label="epsK gene" CDS 440379..442088 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27897378; Product type ph :phenotype" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388310.1" /db_xref="EnsemblGenomes-Gn:BSU04290" /db_xref="EnsemblGenomes-Tr:CAB12236" /db_xref="GOA:O31487" /db_xref="InterPro:IPR018763" /db_xref="SubtiList:BG12059" /db_xref="UniProtKB/Swiss-Prot:O31487" /translation="MLCVMMLLFSAIASFPVSAQAKDQDAGILIIYSTLDGKESSQVK MLDLLAGHFTSHVTVKKDSDVEASDFKGKDHVIYYGQTKRKLSQKLLSLISGVKKPVV AIGYNAGQISQFSGLSLARKENVFQVHSRSEKADVSLESGLNVLSVSGLKGTALYTFK ADEGTTHSFIWKTKKGNVYIGLTNLLNDNLIVAKQLREAFGEKAGTTLLYLRLEDISP MSDEKLLLQAGTYLHKRHIPFILAVIPVYLNPETGDKVYLSNQPKMVKVLKKLQSMGG SIIVHGYTHAYRYSETGEGFEFWDAKADQPITSGNAEDPPSILEKEQDFPNEQAYHSY LEPFREKEETYTKQKLTRAIEDLTSSGLYPLAFEAPHYTMSEYGYQIASQYFTSIFGQ VQLSSTTWKTSGAPPFVTAPSMLHGMTLYPETIGFVDTSKQNPLGEMEEHISQMIDFE GGVAGGFYHPYLGMKYLPELVDQMERIPDSEWLDLKKTKQTVKTDKVEIHTSGDGTIQ VKNGVSPIYEFFDHHRQTPLEKALWILSAVVLLFVIMFVSYTFYLRATLKKRIFKERR SLG*" /label="ydaL CDS" gene 440379..442088 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /label="ydaL gene" CDS 442081..443343 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /EC_number="2.4.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378, 28296273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase associated to biofilm formation" /protein_id="NP_388311.1" /db_xref="EnsemblGenomes-Gn:BSU04300" /db_xref="EnsemblGenomes-Tr:CAB12237" /db_xref="GOA:P96587" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12060" /db_xref="UniProtKB/Swiss-Prot:P96587" /translation="MGNTLFFISLSLIWVMLLYHMFLMQGGFRHYMTFERNIPKWREN MKELPKVSVLIPAHNEEVVIRQTLKAMVNLYYPKDRLEIIVVNDNSSDRTGDIVNEFS EKYDFIKMVITKPPNAGKGKSSALNSGFAESNGDVICVYDADNTPEKMAVYYLVLGLM NDEKAGAVVGKFRVINAAKTLLTRFINIETICFQWMAQGGRWKWFKIATIPGTNFAIR RSIIEKLGGWDDKALAEDTELTIRVYNLGYHIRFFPAAITWEQEPETWKVWWRQRTRW ARGNQYVVLKFLAQFFKLKRKRIIFDLFYFFFTYFLFFFGVIMSNAIFVVNLFYDLHL SVGFLAMILWILAFFLFMTEVMITLSIEKTEMNKQNFFIVFLMYFTYSQAWIVLVIYS LFVEIKHRLFKQEVKWYKTERYNQHKSG*" /label="ydaM CDS" gene 442081..443343 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /label="ydaM gene" CDS 443349..445460 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative regulator of exopolysaccharide synthesis" /protein_id="NP_388312.1" /db_xref="EnsemblGenomes-Gn:BSU04310" /db_xref="EnsemblGenomes-Tr:CAB12238" /db_xref="GOA:O31488" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR018513" /db_xref="SubtiList:BG12061" /db_xref="UniProtKB/Swiss-Prot:O31488" /translation="MKQIMIFLTSFMLLAMTGQTALAKDVQVSGSLLGKSSQEQAKQQ VLTSELITLYGSKDSAELTYQIPAGASSGNQQLVIEYEASNLLISPSSLTVVIDDEPV KTLKLDGDSKRKTVKLNLNKSQSAQGYHNVSLKFYGVMKEGVCVRQDTSGNWIKIYPD SRLTLADSSEAKGTSLDHYPYPFAQSGNTAEETAIVIPDNPSSAEIEAAVKTEGYLKT VDSSVSIAYVTESELKKIDKPTIVIGVDKHWNGKVKKLLKQAGLQAKGENLLLAERVL KAEGKQQPVLFAQAASEDALTKKISVMTDQTYTGQLSGDTLSISKLQQTEKKESDKLT LENFGAGDITIGADKTSSAHYFYPASAVLDENQSAKLSLKLKKSETIQASTAENESAS QAAELKVMINGQPHSVRLDELGKEDKNGFYHVTVKVDPKLLQKNRYIDIQFVTTGLKE NNPCNTTDEEKWVFIDKNSTLSYAIKGMSPSADFQEWPLPYAGNQDQTTLIVLPDTVS QSKLEELSLVTESFGNEAQHSYTVKKSSDVTANDAKGRNLIFIGGINQFSLLKEKSSD LLVPQEKNGSFDVSSFEMLNETTKQVVFTQASVWDSRYTMAVFAPSKGDGTAVTKEII SYLNSNDESATVLNETNSQQVFTNHQQLKSETNSSDAEQPTQDHSQKWMYIGVLALIM VVAAVFIWIAVRRKKRKTDTE*" /label="ydaN CDS" gene 443349..445460 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /label="ydaN gene" downshifts 445444 /Source="Nicolas_upshifts" /id="D196" /incds=0 /nref=18 /ntot=91 /MaxReadThrough="0.438479999999999" /MaxDrop="4.36576" /score="34.1370207" /energy="-9.9" /TU="NA" /idTUdmin="U336" /TUdmin="-4598" /isTUend="FALSE" /label="downshifts" promotor_-35 445557..445564 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 445579..445598 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 445586 /Source="Nicolas_upshifts" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 445596..445739 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /product="ATP-, cyclic di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 20511502, 23086297, 25086507, 25086509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 20511502, 23086297, 25086507, 25086509; Product type n: RNA" /function="16.3: Control" /label="swaO RNA" gene 445596..445739 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /label="swaO gene" downshifts 445737 /Source="Nicolas_upshifts" /id="D197" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="7.43698" /MaxDrop="5.83561" /score="30.4392599" /energy="-14.7" /TU="U336" /idTUdmin="U336" /TUdmin="-4305" /isTUend="FALSE" /label="downshifts" S_feature 445782..445935 /Source="Nicolas_S_feature" /locus_tag="new_486278_486431" /HighExp="LPhT, LBGstat, LPh, T-1.10H, T-0.40H, G135, G180, T-1.40H, G150, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S142" CDS 445936..447759 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cyclic di-AMP controlled transporter of potassium" /protein_id="NP_388313.1" /db_xref="EnsemblGenomes-Gn:BSU04320" /db_xref="EnsemblGenomes-Tr:CAB12239" /db_xref="GOA:P96589" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12062" /db_xref="UniProtKB/Swiss-Prot:P96589" /translation="MYHSIKRFLIGKPLKSQAAGEQKLTKLKALAMLSSDALSSVAYG TEQILIILATISAAAFWYSIPIAVGVLILLLALILSYRQIIYAYPQGGGAYIVSKENL GEKPGLIAGGSLLVDYILTVAVSISAGTDAITSAFPALHDYHVPIAIFLVLVIMILNL RGLSESASILAYPVYLFVVALLVLIAVGLFKLMTGQIDQPAHHTSLGTPVAGITLFLL LKAFSSGCSALTGVEAISNAIPAFKNPPARNAARTLAMMGILLAILFSGITVLAYGYG TAPKPDETVVSQIASETFGRNVFYYVIQGVTSLILVLAANTGFSAFPQLAFNLARDQY MPRMFTVRGDRLGFSNGIIFLGFASIVLIILFGGQTEHLIPLYAVGVFIPFTLSQTGM CMKWIKQKPKGWIGKMLINSCGALISFMVLSILFVTKFNVVWPVLIFMPIVVLLFFAI KNHYTAVGEQLRIVDKEPEEIKGTVVIVPVAGVTTVVQKSIHYAKSLSDQVIAVHVSF DREQEKKFEKRWEELNNGVRLVTLHSSYRSLVHPFDKFLETVEAKAKKEQFSVMVLFP QFITKKRWHTILHNQSAFLLRVRLFWKKDIMVATLPYHFKK*" /label="kimA CDS" gene 445936..447759 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /label="kimA gene" downshifts 447751 /Source="Nicolas_upshifts" /id="D198" /incds=0 /nref=50 /ntot=181 /MaxReadThrough="3.55206" /MaxDrop="4.7232" /score="6.00201196" /energy="-13.9" /TU="U336" /idTUdmin="U336" /TUdmin="-2291" /isTUend="FALSE" /label="downshifts" CDS 447818..448267 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /EC_number="3.6.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576788, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NTP pyrophosphohydrolase" /protein_id="NP_388314.1" /db_xref="EnsemblGenomes-Gn:BSU04330" /db_xref="EnsemblGenomes-Tr:CAB12240" /db_xref="GOA:P96590" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11956" /db_xref="UniProtKB/Swiss-Prot:P96590" /translation="MYTQGAFVIVLNESQQILLVKRKDVPLWDLPGGRVDPGESAEEA AVREILEETGYNAALSAKIGVYQRPKFQDEQHLFFGSITGGQAMADGTETAGLKWVSP GRLPLFMVPNRKRQINDFKNGAQDVNVTVKDSGLLAAIDLLKRRLGK*" /label="nudT CDS" gene 447818..448267 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /label="nudT gene" promotor_-35 448280..448286 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 448301..448319 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 448302 /Source="Nicolas_upshifts" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="upshifts" CDS 448334..450058 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /EC_number="1.2.3.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291680, 16513748, 10220166, 23611909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-phosphate generating pyruvate oxidase" /protein_id="NP_388315.1" /db_xref="EnsemblGenomes-Gn:BSU04340" /db_xref="EnsemblGenomes-Tr:CAB12241" /db_xref="GOA:P96591" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12063" /db_xref="UniProtKB/Swiss-Prot:P96591" /translation="MAHKTAGQAMTELLEQWGVDHVYGIPGDSINEFIEELRHERNQL KFIQTRHEEVAALAAAAEAKLTGKIGVCLSIAGPGAVHLLNGLYDAKADGAPVLAIAG QVSSGEVGRDYFQEIKLEQMFEDVAVFNREVHSAESLPDLLNQAIRTAYSKKGVAVLS VSDDLFAEKIKREPVYTSPVYIEGNLEPKKEQLVTCAQYINNAKKPIILAGQGMKKAK RELLEFADKAAAPIVVTLPAKGVVPDKHPHFLGNLGQIGTKPAYEAMEECDLLIMLGT SFPYRDYLPDDTPAIQLDSDPAKIGKRYPVTAGLVCDSALGLRELTEYIERKEDRRFL NACTEHMQHWWNEIEKDETEATTPLKPQQVVARLQEAAADDAVLSVDVGTVTVWMARH FKMNANQDFIVSSWLATMGCGLPGAIAASLSEPERQAIAVCGDGGFSMVMQDLPTAVK YKLPITVVILNNENLGMIEYEQQVKGNIDYVTKLQNVDYAAFAESCGAKGIKVTKAEE LAPAFHEALHSDQPVVVDVMIGNEPPLPGKITYGQAKGFSKYMLKNFFENQKFEMPSL KKSLKRLF*" /label="poxB CDS" gene 448334..450058 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /label="poxB gene" S_feature complement(449170..450029) /Source="Nicolas_S_feature" /locus_tag="new_489666_490525_c" /HighExp="H2O2, Paraq, G180, G150, Oxctl, Diami, dia15, G135, C30, dia5" /AntisenseName="ydaP" /AntisenseCor="-5.0529608261635599E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S143" S_feature complement(450031..450142) /Source="Nicolas_S_feature" /locus_tag="new_490527_490638_c" /HighExp="dia5, M0t45, S0, S2, S1, Paraq, GM 120, Lbstat, MG 5, UNK1" /AntisenseName="ydaP" /AntisenseCor="1.7026698118644101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S144" downshifts 450042 /Source="Nicolas_upshifts" /id="D199" /incds=0 /nref=50 /ntot=166 /MaxReadThrough="5.18566" /MaxDrop="6.66568" /score="7.55338633" /energy="-5.3" /TU="U337" /idTUdmin="U336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(450050..450253) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513943.1" /translation="MIRISMQGQMHLPLKQDAFVLLSVSSMAKSVPNTYTDHFMNSNM LKIHLFPKKKKKTRALRAPVFLK*" /label="hypothetical protein CDS" gene complement(450050..450253) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /label="gene" downshifts complement(450074) /Source="Nicolas_upshifts" /id="D200" /incds=0 /nref=5 /ntot=55 /MaxReadThrough="4.75809" /MaxDrop="8.06239" /score="11.2659249" /energy="-9.1" /TU="U338,U340,U341" /idTUdmin="U338" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(450102..450202) /Source="Nicolas_upshift_promotors" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 450111..450116 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 450133..450151 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(450142) /Source="Nicolas_upshifts" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature 450143..450358 /Source="Nicolas_S_feature" /locus_tag="new_490639_490854" /HighExp="Etha, S4, S8, S5, C30, S7, B60, S6, Salt, B36" /AntisenseName="ydzK" /AntisenseCor="3.8830946787094797E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigB" /TUshortPSig="0.914, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S145" upshifts 450143 /Source="Nicolas_upshifts" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(450209..450280) /Source="Nicolas_S_feature" /locus_tag="new_490705_490776_c" /HighExp="Sw, B60, dia15, dia5, BI, Etha, BC, M9-stat, C90, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S146" downshifts complement(450252) /Source="Nicolas_upshifts" /id="D201" /incds=0 /nref=21 /ntot=191 /MaxReadThrough="5.39949" /MaxDrop="5.81865" /score="3.34912028" /energy="-20.3" /TU="U340,U341" /idTUdmin="U343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(450281..450547) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_003097680.1" /db_xref="EnsemblGenomes-Gn:BSU04359" /db_xref="EnsemblGenomes-Tr:CAX52551" /db_xref="GOA:C0H3V4" /db_xref="UniProtKB/Swiss-Prot:C0H3V4" /translation="MSVFILFYLWIVPIVIGILCSVAAHKSKGKMRVAPGIAMIVLSI ISLITAFTAGHTNFHVFIGGMFLFGTFLVGSAFPFFFGLKKKEK*" /label="ydzK CDS" gene complement(450281..450547) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /label="ydzK gene" promotor_-10 complement(450563..450582) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(450581) /Source="Nicolas_upshifts" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(450594..450601) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(450651..451928) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton-coupled manganese transporter" /protein_id="NP_388317.1" /db_xref="EnsemblGenomes-Gn:BSU04360" /db_xref="EnsemblGenomes-Tr:CAB12243" /db_xref="GOA:P96593" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG12065" /db_xref="UniProtKB/Swiss-Prot:P96593" /translation="MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAY IDPGNFATNISAGSKYGYMLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFP KPVSIGLWIQGELVIIATDLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRR GYRSLEAGIAGMLFVVVIAFALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGA TVMPHAIYLHSALTQRRVVGKTDAERKKIFRFEFIDILIAMLIAGAINASMLIVAAAL FFKNGLFVEDLDVAFQQFGHLVSPMSAALFGIGLLVAGLSSSSVGTLSGDVIMQGFIN YRIPLYVRRFITIIPPILIIASGVNPTTALVLSQVVLSFGIAFALIPLIMFTSNKRIM GSLINAKWITVVSWLIAVLIVALNVFLIVDTFR*" /label="mntH CDS" gene complement(450651..451928) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /label="mntH gene" downshifts complement(450670) /Source="Nicolas_upshifts" /id="D202" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="5.8826" /MaxDrop="4.8109" /score="28.3182556" /energy="-9.6" /TU="U341,U343" /idTUdmin="U342" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(451990..452009) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(452002) /Source="Nicolas_upshifts" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(452004..452081) /Source="Nicolas_S_feature" /locus_tag="new_492500_492577_c" /HighExp="S6, S8, S7, Etha, S5, Salt, BT, Heat, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S147" promotor_-35 complement(452022..452029) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(452065..452084) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(452081) /Source="Nicolas_upshifts" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(452098..452107) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(452158..452415) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388318.1" /db_xref="EnsemblGenomes-Gn:BSU04370" /db_xref="EnsemblGenomes-Tr:CAB12244" /db_xref="GOA:P96594" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG12066" /db_xref="UniProtKB/Swiss-Prot:P96594" /translation="MLSFLVSLVVAIVIGLIGSAIVGNRLPGGIFGSMIAGLIGAWIG HGLLGTWGPSLAGFAIFPAIIGAAIFVFLLGLIFRGLRKEA*" /label="ydaS CDS" gene complement(452158..452415) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /label="ydaS gene" downshifts complement(452166) /Source="Nicolas_upshifts" /id="D203" /incds=0 /nref=7 /ntot=33 /MaxReadThrough="4.70076" /MaxDrop="4.7213" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" downshifts complement(452232) /Source="Nicolas_upshifts" /id="D204" /incds=1 /nref=2 /ntot=69 /MaxReadThrough="7.55545" /MaxDrop="2.8244" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS complement(452493..452945) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388319.1" /db_xref="EnsemblGenomes-Gn:BSU04380" /db_xref="EnsemblGenomes-Tr:CAB12245" /db_xref="InterPro:IPR018691" /db_xref="SubtiList:BG12067" /db_xref="UniProtKB/Swiss-Prot:P96595" /translation="MPWSMKDYPASLKNLEKPVRKKAIDIANAMIDEGYEEGRAIPIA TSKAKEWAENASTDEIDDFLTHDDETERDADPSSGSGPELMNKAEHVIKHKKGWAVKA EGAKRVSEIKDTKKEAIERAKEIAAHKGTEVIVHLADGSVQRKIKTGS*" /label="ydaT CDS" gene complement(452493..452945) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /label="ydaT gene" promotor_-10 complement(452964..452982) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(452981) /Source="Nicolas_upshifts" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(452996..453002) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 453014 /Source="Nicolas_upshifts" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 453022..453041 /Source="Nicolas_upshift_promotors" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 453063..453881 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388320.1" /db_xref="EnsemblGenomes-Gn:BSU04390" /db_xref="EnsemblGenomes-Tr:CAB12246" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG12068" /db_xref="UniProtKB/Swiss-Prot:P96596" /translation="MPTERKEDLHQQLKEIEKWEKDQQKVWFWEKLSRLPFQLLDKLT PEFIQKKIGKLLDEVGSFVQTGGQYLTSEKQIIRMFQKKLPEEIFESLEDIRKAPLPV MDEIAEGMGKNRTNAATVQGATTGVGGVFTLAADIPAVLGLSLKTLQDIAVAYGYDPK EKKERVFIVKCLQLTSADVVGKRSILQELKHYDQDRTYKNVASQIQGWREVVLGYRDT FGWKKLFQIVPVAGMVFGAAANRSTLNDITETGMMLYKKRRILERLKETEREME*" /label="ydbA CDS" gene 453063..453881 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /label="ydbA gene" downshifts 453872 /Source="Nicolas_upshifts" /id="D205" /incds=0 /nref=118 /ntot=223 /MaxReadThrough="0.66117" /MaxDrop="4.41502" /score="5.38936313" /energy="-9.2" /TU="NA" /idTUdmin="U344" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 453949..453955 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 453969..453987 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 453977 /Source="Nicolas_upshifts" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="upshifts" CDS 454010..454381 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651322, 9669336, 9763714, 12562800, 21421783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651322, 9669336, 9763714, 12562800, 21421783; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein glucose starvation induced" /protein_id="NP_388321.1" /db_xref="EnsemblGenomes-Gn:BSU04400" /db_xref="EnsemblGenomes-Tr:CAB12247" /db_xref="InterPro:IPR019626" /db_xref="SubtiList:BG10826" /db_xref="UniProtKB/Swiss-Prot:P26907" /translation="MADNNKMSREEAGRKGGETTSKNHDKEFYQEIGQKGGEATSKNH DKEFYQEIGEKGGEATSKNHDKEFYQEIGEKGGEATSENHDKEFYQEIGRKGGEATSK NHDKEFYQEIGSKGGNARNND*" /label="gsiB CDS" gene 454010..454381 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /label="gsiB gene" downshifts complement(454014) /Source="Nicolas_upshifts" /id="D206" /incds=0 /nref=1 /ntot=25 /MaxReadThrough="1.50212" /MaxDrop="4.6705" /score="-7.76438364" /energy="-14.2" /TU="NA" /idTUdmin="U346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 454398 /Source="Nicolas_upshifts" /id="D207" /incds=0 /nref=153 /ntot=219 /MaxReadThrough="3.75525" /MaxDrop="8.3301" /score="39.7307477" /energy="-16.6" /TU="U345" /idTUdmin="U345" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" upshifts complement(454432) /Source="Nicolas_upshifts" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(454435..454438) /Source="Nicolas_upshift_promotors" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 454460..454467 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 454479..454498 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 454486 /Source="Nicolas_upshifts" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="upshifts" CDS 454513..454854 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_388322.1" /db_xref="EnsemblGenomes-Gn:BSU04410" /db_xref="EnsemblGenomes-Tr:CAB12248" /db_xref="GOA:P96597" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR019780" /db_xref="SubtiList:BG12069" /db_xref="UniProtKB/Swiss-Prot:P96597" /translation="MSKMQNLLAIANEVKEKHANFSISEVNDHCVRLAVFTGEYDWHH HPDSDELFIVLEGELLIDFKDKETAVLKANDSLLIPKGTVHRTRSYVRTVNLCVEHKQ AETVIIEEQPC*" /label="ydbB CDS" gene 454513..454854 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /label="ydbB gene" CDS 454848..455207 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388323.1" /db_xref="EnsemblGenomes-Gn:BSU04420" /db_xref="EnsemblGenomes-Tr:CAB12249" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR032555" /db_xref="SubtiList:BG12070" /db_xref="UniProtKB/Swiss-Prot:P96598" /translation="MLIKKMICEVDAANAEAFAKAQSQWEALSHISGFIKQAGGWRKT IDEPLTAEIISVWENREAYDHFMENEHDSIYEENDQKAVILSIEVTVYEEDKPFVHDL LHNPDIRYEPNWTVLKA*" /label="ydbC CDS" gene 454848..455207 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /label="ydbC gene" S_feature complement(454910..455203) /Source="Nicolas_S_feature" /locus_tag="new_495406_495699_c" /HighExp="Etha, Salt, M9-stat, C30, Heat, Sw, B60, S8, C90, UNK1" /AntisenseName="ydbC" /AntisenseCor="0.16172626521480701" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S148" downshifts 455148 /Source="Nicolas_upshifts" /id="D208" /incds=0 /nref=2 /ntot=130 /MaxReadThrough="1.8663" /MaxDrop="2.67081" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 455192 /Source="Nicolas_upshifts" /id="D209" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="0.252220000000001" /MaxDrop="2.61185" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(455244..456065) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /EC_number="1.11.1.6" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15231799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative manganese-containing catalase" /protein_id="NP_388324.1" /db_xref="EnsemblGenomes-Gn:BSU04430" /db_xref="EnsemblGenomes-Tr:CAB12250" /db_xref="GOA:P80878" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR027407" /db_xref="SubtiList:BG12071" /db_xref="UniProtKB/Swiss-Prot:P80878" /translation="MFKHTKMLQHPAKPDRPDPLFAKKMQEILGGQFGEISVAMQYLF QGWNTRGNEKYKDLLMDTATEELGHVEMIATMIARLLEDAPLDQQEKAAEDPVIGSIL GGMNPHHAIVSGLGAMPESSTGVPWSGGYIVASGNLLADFRANLNAESQGRLQVARLF EMTDDKGVKDMLSFLLARDTMHQNQWLAAIKELEAQEGPVVPGTFPKALEKQEFSHQL INFSEGEVSAEQNWLNEKAPDGEAFEYVKEAKTFGEKPELKPAPPFVHNTLPGRE*" /label="ydbD CDS" gene complement(455244..456065) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /label="ydbD gene" downshifts complement(455248) /Source="Nicolas_upshifts" /id="D210" /incds=0 /nref=62 /ntot=214 /MaxReadThrough="4.23505" /MaxDrop="6.82771" /score="-6.55917314" /energy="-13.1" /TU="U348" /idTUdmin="U348" /TUdmin="-310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(456087..456105) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(456108) /Source="Nicolas_upshifts" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(456119..456125) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(456150..457202) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:1809844, 10708364, 11566984, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1809844, 10708364, 11566984, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane bound C4-dicarboxylate binding sensor protein" /protein_id="NP_388325.1" /db_xref="EnsemblGenomes-Gn:BSU04440" /db_xref="EnsemblGenomes-Tr:CAB12251" /db_xref="GOA:P96600" /db_xref="InterPro:IPR004682" /db_xref="InterPro:IPR018389" /db_xref="SubtiList:BG12072" /db_xref="UniProtKB/Swiss-Prot:P96600" /translation="MKSLLACLALMIAGIATALFIGFHDHTGNKKIVYDDDQEGLQDQ IVFKFSHVVAENTPKGLAANKFADLVNEKSGGKIKIEVFPNGSLYSDIEEIEALQNGD VQFIAPSTSKLGMLSPEWGVLDLPYAFTDYNAVKKGLNGSIGTQLFDSLKKNQLKGLA YWTNGFKQITTNQGPVKTPDDLKGQDLRIMQSDVIEDQFKLLGATPHQESFNSTFQLL ENNVVDGEENTISNIYSKKFYNVQDYLTISSHGYLGYAVMTDEHFWKAQTPETRRILT EAMKETTEWNETYAEQMNKEQLEEIKKNSAIHIYELSDKEKQEWMKRLDPVYRQYEPI FGRELIRELLELRKDS*" /label="dctB CDS" gene complement(456150..457202) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /label="dctB gene" promotor_-35 456462..456469 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 456484..457271 /Source="Nicolas_S_feature" /locus_tag="new_496980_497767" /HighExp="LBGstat, Diami, T-0.40H, T0.0H, T0.30H, Heat, UNK1, GM-0.1, MG 90, Fru" /AntisenseName="dctB" /AntisenseCor="0.64205060306327899" /AntisenseRegPval="-31.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S149" promotor_-10 456484..456503 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 456485 /Source="Nicolas_upshifts" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(457215..457234) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(457220) /Source="Nicolas_upshifts" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(457248..457255) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 457272..458879 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388326.1" /db_xref="EnsemblGenomes-Gn:BSU04450" /db_xref="EnsemblGenomes-Tr:CAB12252" /db_xref="GOA:P96601" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12073" /db_xref="UniProtKB/Swiss-Prot:P96601" /translation="MNKKKLSIRWKITILSYILVIFSFLIGGIVLIGNIQHTEERELK KRLMNTARTVSEMTEVKEALARKKQTEAVRHAVEEIRMINEADYIVVMDMNHIRYTHP VSTSIGKKSEGADEEAAFAEHIYFSEAKGEIGTAVRAFYPVKDQDLNQIGVVLVGKTL PGIADILLHLKRDIAFIVVLTLGFGLAGSFLLARHIKKQMFQLEPHEIVRMYEERTAT FHSMNEGVIAIDNRLVITIFNEKAKQIFEVQGDLIGKVIWEVLKDSRLPEIVERNKAV YNEEIRVSGKVIMSSRIPIVMKKKVIGAVAIFQDRTEAAKMAEELTGVRNFVEALRVQ NHEHMNKLHTIAGLIQLGKSEKALQLAFQASTEQENVTEFLHRSIQNDAAAGLLLSKI RRGRELGIAVHIDENSSLQQFPEHVDQHDIVVLLGNLIENAFGSFETVQSEDKRIDIS IEQTDDILAILIEDNGCGIEPTHMPRLYDKGFTVNKTGGTGYGLYLVKQIIDKGSGTI EVDSHAGQGTSFSIVFPMKGEEAQHGS*" /label="dctS CDS" gene 457272..458879 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /label="dctS gene" CDS 458869..459549 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388327.1" /db_xref="EnsemblGenomes-Gn:BSU04460" /db_xref="EnsemblGenomes-Tr:CAB12253" /db_xref="GOA:P96602" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12074" /db_xref="UniProtKB/Swiss-Prot:P96602" /translation="MARKEWKVLLIEDDPMVQEVNKDFITTVKGVTVCATAGNGEEGM KLIKEEQPDLVILDVYMPKKDGIKTLQEIRKQKLEVDVIVVSAAKDKETISLMLQNGA VDYILKPFKLERMRQALEKYKQYKQKIEANDTLSQEQLDAILNIPQQAVQDLPKGLNH FTMNEVTAFLKQQTASLSAEEVAKALGIARVTARRYLDYLEKTGIIKLDVQYGGVGRP VNRYVLKG*" /label="dctR CDS" gene 458869..459549 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /label="dctR gene" S_feature 459550..459624 /Source="Nicolas_S_feature" /locus_tag="new_500046_500120" /HighExp="Sw, Diami, Mt0, G150, BI, Lbstat, M40t45, Lbtran, Mal, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S150" promotor_-35 459591..459598 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 459613..459630 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 459626 /Source="Nicolas_upshifts" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="upshifts" CDS 459670..460935 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480; Product type t: transporter" /codon_start=1 /transl_table=11 /product="C4-dicarboxylate transport protein" /protein_id="NP_388328.1" /db_xref="EnsemblGenomes-Gn:BSU04470" /db_xref="EnsemblGenomes-Tr:CAB12254" /db_xref="GOA:P96603" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR023954" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12075" /db_xref="UniProtKB/Swiss-Prot:P96603" /translation="MKLFKNLTVQVITAVIIGVIVGLVWPDVGKEMKPLGDTFINAVK MVIAPIIFFTIVLGIAKMGDMKKVGKVGGKAFIYFEVVTTLALIIGLFVVNIMKPGAG LDYSKLEKGDVSQYTQNGGQGIDWIEFITHIVPSNMVDAFAKGDILQVLFFSILFGVG LAALGEKGKSVIDFFDKVSHVFFKIIGYIMRAAPIGAFGAMAYTIGHFGLDSIKPLAS LMMSVYITMFLFVFVALNIICKLYGFSLWNYLRFIKDELLIVLGTSSSESVLPRMMDK MERYGCSKSVVGLVIPTGYSFNLDGTSIYLSMATVFLAQVFGVDLSIGQQITIILVLM LTSKGAAGVTGSGFIVLASTLSALQVIPLEGLALLLGVDRFMSEGRAIVNLIGNGIAT IIVAKSENEFDEAKSIEAVEGMKKMKTAV*" /label="dctP CDS" gene 459670..460935 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /label="dctP gene" downshifts 460928 /Source="Nicolas_upshifts" /id="D211" /incds=0 /nref=175 /ntot=235 /MaxReadThrough="3.99042" /MaxDrop="7.04798" /score="45.0636559" /energy="-12.6" /TU="NA" /idTUdmin="U351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(460982) /Source="Nicolas_upshifts" /id="D212" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.588190000000001" /MaxDrop="3.06255" /score="19.3433396" /energy="-12.6" /TU="NA" /idTUdmin="U350" /TUdmin="-4818" /isTUend="FALSE" /label="downshifts" misc_feature 461019..461036 /Source="Nicolas_upshift_promotors" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 461021 /Source="Nicolas_upshifts" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 461083..462135 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388329.1" /db_xref="EnsemblGenomes-Gn:BSU04480" /db_xref="EnsemblGenomes-Tr:CAB12255" /db_xref="GOA:P96604" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG12076" /db_xref="UniProtKB/Swiss-Prot:P96604" /translation="MAALVKFFQHPGVRRFSIFVVLTGVLYLFKSMINLILLTFIFTF LMDRLELVVRQFVSQFFRVSQRVVITFLYMLLAVLLTVGGFVFYPVVAAQIQQLVKQI KHIAYHPDSIPFFDEITSVFGDINISSYVKEGFNVVYTYLADISTFGLQVVMALILSM FFLFEKKRLSEFMAKFKTSKLRVFYEEIAFFGSKFARTFGKVLEAQFIIALVNCILTF IALWIMHFPQLFGLSIMVFFLGLIPVAGVVISLIPLSIIAYSTGGGMYVLYIVLVIFA IHAIETYFLNPKLMSAKTELPIFFTFTVLIFSEHFFGIWGLIIGIPIFVFLLDILDVT NKEDRSKGPRENSDKK*" /label="ydbI CDS" gene 461083..462135 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /label="ydbI gene" S_feature 462136..462379 /Source="Nicolas_S_feature" /locus_tag="new_502632_502875" /HighExp="S8, S5, S6, LoTm, S7, S3, LBGstat, LBGexp, Paraq, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87223499999999998" /TUshortSig="Sig-" /TUshortPSig="0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S151" downshifts 462336 /Source="Nicolas_upshifts" /id="D213" /incds=0 /nref=6 /ntot=45 /MaxReadThrough="6.05001" /MaxDrop="3.52626" /score="17.6400305" /energy="-12.4" /TU="U352" /idTUdmin="U351" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" CDS 462412..463338 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding subunit)" /protein_id="NP_388330.1" /db_xref="EnsemblGenomes-Gn:BSU04490" /db_xref="EnsemblGenomes-Tr:CAB12256" /db_xref="GOA:P96605" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12077" /db_xref="UniProtKB/Swiss-Prot:P96605" /translation="MAEPILHIEGLDKKIGSKQILKQISMDVMEGEIIGLLGPNGSGK TTLIRIIVGLLKQNSGSVTISGFQHDTEFEKAMEAVGAIVENPEFYPYLTGWENLKHF ANMHKKIADERLDEVVERVGLTSAIHDKVKTYSLGMRQRLGIAQAILHRPKLLILDEP TNGLDPAGMKDFRDHIKELAEMEGTAVLFATHLLREVEDLCDRVIIIQKGEIKAEVSL QGTDQTTEKAIIEVQPQEKALNWLTGNQYQAESQDGTIVVEVAKENIPELNRSLVGQD LNVFSITPYTQSLEDEFIKATTAHQEEGEELV*" /label="ydbJ CDS" gene 462412..463338 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /label="ydbJ gene" CDS 463358..464098 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux ABC-transporter (permease subunit)" /protein_id="NP_388331.1" /db_xref="EnsemblGenomes-Gn:BSU04500" /db_xref="EnsemblGenomes-Tr:CAB12257" /db_xref="GOA:P96606" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12078" /db_xref="UniProtKB/Swiss-Prot:P96606" /translation="MKLFNRKVTLVSLILMAVFQFFMALIIKRIVISAGTDENFIGYL SYTPSLNILLQALTIVIAATIVSMEFDKKTIKFLLIRPVKRQKVFWSKLITVVMVSFY LYLAYYILALLFGLLFFGTSVTAESKTLLVNTLALIGSNWLEAVMMGLFGLLCSSLFR NSAVAVVVSFVVLYGASTLVQLMKLFENKWGSFLLFANTDFTQYRSGETALFSGMTPL FSIGILIIHAIFFIVVGWWCFCKRDVRV*" /label="ydbK CDS" gene 463358..464098 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /label="ydbK gene" misc_feature 464157..464176 /Source="Nicolas_upshift_promotors" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 464162 /Source="Nicolas_upshifts" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 464193..464528 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928292; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative glyco-prenyl flippase subunit" /protein_id="NP_388332.1" /db_xref="EnsemblGenomes-Gn:BSU04510" /db_xref="EnsemblGenomes-Tr:CAB12258" /db_xref="GOA:P96607" /db_xref="SubtiList:BG12079" /db_xref="UniProtKB/Swiss-Prot:P96607" /translation="MRNFITALPIVLLLGFSFVSFMFQFEHLVYFRLALGLFSLVGLY MIYKMKTGIRYFIIYLYASWIVLAAVTAFEEPIFSSFFFGGLVMTMGYLTYMLIYLGM KQDRDANPV*" /label="ydbL CDS" gene 464193..464528 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /label="ydbL gene" downshifts 464503 /Source="Nicolas_upshifts" /id="D214" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="5.33473" /MaxDrop="5.39081" /score="25.8152101" /energy="-18.4" /TU="U352,U353" /idTUdmin="U352" /TUdmin="-1177" /isTUend="FALSE" /label="downshifts" S_feature 464548..464617 /Source="Nicolas_S_feature" /locus_tag="new_505044_505113" /HighExp="ferm, nit, S2, S0, Gly, M0t45, M0t90, Lbstat, M/G, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.99, 0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S152" promotor_-35 464583..464590 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 464604..464623 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 464618 /Source="Nicolas_upshifts" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 464656..465801 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA dehydrogenase" /protein_id="NP_388333.1" /db_xref="EnsemblGenomes-Gn:BSU04520" /db_xref="EnsemblGenomes-Tr:CAB12259" /db_xref="GOA:P96608" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013107" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG12080" /db_xref="UniProtKB/Swiss-Prot:P96608" /translation="MSLFIQNDQQRQWMEKIGRIADEFQQTAAEDDEQGRFPAEKIQK LRDAGYTALTLPASHGGGGISVYDMLLFQERLARGDAPTALSIGWHLSVIGELGEGNS WDEDVFAFVAKEVQNGAVINRAATEAKTGSPTRGGRPGTHAVKKDGKWAVNGRKTFTT MSQALDYFLVTAWIEDKQTTGVFLIHKDDPGLSIEETWDMMAMRATGSHDLVLNEVML DENKLVELLQGPRGAKPNGWLLHIPAIYLGVAQAARDYAVQFASEYSPNSLNGPIKNV PAVQQRTGEMELELLNARHFLFHIAQLYDDPVRRPHLTSELGAAKHIVTNAALSVVDK AMRIVGAKSLERTNPLQRYYRDVRAGLHNPPMDDAVIHKLAAEAFES*" /label="ydbM CDS" gene 464656..465801 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /label="ydbM gene" downshifts 465783 /Source="Nicolas_upshifts" /id="D215" /incds=0 /nref=13 /ntot=123 /MaxReadThrough="2.90782" /MaxDrop="4.20573" /score="9.48525091" /energy="-7" /TU="NA" /idTUdmin="U353" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(465826..466005) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /experiment="publication(s) with functional evidences, PMID:12354229, 16428414, 18697947, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16428414, 18697947, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="NP_388334.1" /db_xref="EnsemblGenomes-Gn:BSU04530" /db_xref="EnsemblGenomes-Tr:CAB12260" /db_xref="GOA:P96609" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG12081" /db_xref="UniProtKB/Swiss-Prot:P96609" /translation="MNTNMSGGRRSMPKRKVKTYQQLIQENKEAIMGNPKLMNVIYDR IDRKHQKNLQEQNNT*" /label="fbpB CDS" gene complement(465826..466005) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /label="fbpB gene" downshifts complement(465844) /Source="Nicolas_upshifts" /id="D216" /incds=0 /nref=158 /ntot=207 /MaxReadThrough="2.35872" /MaxDrop="6.38199" /score="26.3317207" /energy="-7" /TU="NA" /idTUdmin="U355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(465959..466123) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513944.1" /db_xref="EnsemblGenomes-Gn:BSU04536" /db_xref="EnsemblGenomes-Tr:CCQ48594" /db_xref="InterPro:IPR025072" /db_xref="UniProtKB/TrEMBL:L8ECQ9" /translation="MTPQSAEIRKKQLIHLLIQNGIYKKSKRHLYELSLTELESEYKH VRRAPEHAEA*" /label="fbpA CDS" gene complement(465959..466123) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /label="fbpA gene" S_feature complement(466006..466174) /Source="Nicolas_S_feature" /locus_tag="new_506502_506670_c" /HighExp="B60, nit, B36, Lbexp, GM 15, GM 10, dia0, S2, GM 25, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99141199999999996" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S153" promotor_-10 complement(466166..466185) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(466176) /Source="Nicolas_upshifts" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(466200..466207) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 466315..466320 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 466336..466354 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 466340 /Source="Nicolas_upshifts" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="upshifts" CDS 466370..467242 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cation efflux system" /protein_id="NP_388335.1" /db_xref="EnsemblGenomes-Gn:BSU04540" /db_xref="EnsemblGenomes-Tr:CAB12261" /db_xref="GOA:P96610" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12082" /db_xref="UniProtKB/Swiss-Prot:P96610" /translation="MERTENLKKGEKGALLNIFAYVILAVVKLVIGILYHSEALRADG LNNGTDIVASVAVLIGLRISQRPADSDHPYGHYRAETISSLVASFIMMAVGIEVLIGG GKAIAGGTTETPNLIAAWTALGSAVFMYGIYLYNKRLAASIKSSALMAAAKDSRSDAF VSAGAFIGVFSSQLKLPWVDPVTAFIIGIIICKTAWDIFKDASHSLTDGFHLKDLEPY KQTVGRIENVHRLKDVKARYLGSTVHIEMVITVDPKLTVEEGHGVADEVEDKIKHEHD VTHVHVHVEPDDIK*" /label="ydbO CDS" gene 466370..467242 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /label="ydbO gene" promotor_-35 466606..466615 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 466628..466643 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 466631 /Source="Nicolas_upshifts" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(467187..467256) /Source="Nicolas_S_feature" /locus_tag="new_507683_507752_c" /HighExp="LPhT, dia15, dia5, Diami, Etha, Lbtran, LBGtran, LBGstat, Mt0, M0t45" /AntisenseName="ydbO" /AntisenseCor="0.18463882527998399" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S154" downshifts complement(467230) /Source="Nicolas_upshifts" /id="D217" /incds=0 /nref=145 /ntot=242 /MaxReadThrough="3.07579" /MaxDrop="6.00116" /score="9.69023537" /energy="-12.3" /TU="U359" /idTUdmin="U359" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 467243..467592 /Source="Nicolas_S_feature" /locus_tag="new_507739_508088" /HighExp="Salt, Paraq, G135, ferm, Oxctl, T-0.40H, G150, Lbexp, T3.0H, T2.30H" /AntisenseName="ydbP" /AntisenseCor="-0.27800721625230801" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S155" CDS complement(467257..467577) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388336.1" /db_xref="EnsemblGenomes-Gn:BSU04550" /db_xref="EnsemblGenomes-Tr:CAB12262" /db_xref="GOA:P96611" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12083" /db_xref="UniProtKB/Swiss-Prot:P96611" /translation="MKKITTNEQFNELIQSDKEIIVKFYADWCPDCTRMNMFIGDILE EYNQNDWYELNKDELPDLAEKYQVMGIPSLLIFKNGEKTAHLHSANAKTPEEVTEFLS EHIS*" /label="ydbP CDS" gene complement(467257..467577) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /label="ydbP gene" promotor_-35 467573..467577 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 467586..467600 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 467594..467751 /Source="Nicolas_S_feature" /locus_tag="new_508090_508247" /HighExp="Lbexp, dia0, LBGexp, H2O2, Paraq, Oxctl, G180, Salt, M0t45, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigWXY" /TUshortPSig="0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S156" upshifts 467594 /Source="Nicolas_upshifts" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(467598..467617) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(467613) /Source="Nicolas_upshifts" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(467631..467638) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-35" CDS 467752..468816 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /EC_number="6.3.2.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8662022, 12682299, 22407814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine ligase A" /protein_id="NP_388337.1" /db_xref="EnsemblGenomes-Gn:BSU04560" /db_xref="EnsemblGenomes-Tr:CAB12263" /db_xref="GOA:P96612" /db_xref="InterPro:IPR000291" /db_xref="InterPro:IPR005905" /db_xref="InterPro:IPR011095" /db_xref="InterPro:IPR011127" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11932" /db_xref="UniProtKB/Swiss-Prot:P96612" /translation="MYGGKSAEHNVSLQTALAVIKALNTEKFDIHPIYITEKGEWVRG ARLTEPVSNVKMLQFEQGGSAFSPAALNQEMFPQEASQQNEAIDVVFPLLHGPNGEDG TIQGMLELLNIPYVGNGVLASSAGMDKVVMKHLFAQVGLAQAKYAAFLKKDWTRSPKE SCEEVEQELGYPCFVKPANLGSSVGISKCRNREELQKAFELAFQYDRKVVVEEGINGR EIEIGVLGNDDPKCSVVGEIAPKTDFYDYKAKYEDGDTDLMIPAIVTDEEYATISDMA IKAFKAIDGSGLVRADFFLTADGEVLINEVNTMPGFTPFSMFPLLWKEAGVEYADLIE QLVELAKERHAEKQLIKHTF*" /label="ddlA CDS" gene 467752..468816 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /label="ddlA gene" downshifts 468804 /Source="Nicolas_upshifts" /id="D218" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="5.68418" /MaxDrop="2.53103" /score="3.92144467" /energy="-9.6" /TU="U357,U358" /idTUdmin="U356" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS 468888..470261 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /EC_number="6.3.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase" /protein_id="NP_388338.1" /db_xref="EnsemblGenomes-Gn:BSU04570" /db_xref="EnsemblGenomes-Tr:CAB12264" /db_xref="GOA:P96613" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005863" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG12084" /db_xref="UniProtKB/Swiss-Prot:P96613" /translation="MIKRTVKNIAEMVKGTLANPQYEQTVIHGVATDTRKLEQHQLFI PLKGERFDGHSFVEQAFEAGVAAVLWDRSVPNPPENHAVILVDDTLTALQQLAKAYLQ ELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEI AVLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKED GVLIYIGDEPLLQNAYSCQTKTYGTGTHNDYQLQDVSQSEEGTHFTIKGIENTFFIPI LGKHNVMNAMAAIAAGAYFGIAPEDAAKGLSGLKVTGMRLELIKTDSGLSIINDAYNA SPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYG KLGAFIAEGALKHFEKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKD LIESPLS*" /label="murF CDS" gene 468888..470261 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /label="murF gene" promotor_-35 470292..470298 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 470312..470323 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 470322 /Source="Nicolas_upshifts" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 470365..470384 /Source="Nicolas_upshift_promotors" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 470366..470540 /Source="Nicolas_S_feature" /locus_tag="new_510862_511036" /HighExp="Cold, ferm, nit, G135, S5, LBGexp, G150, S8, S7, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.76694499999999999" /TUshortSig="SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S157" upshifts 470366 /Source="Nicolas_upshifts" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 470508..470515 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 470530..470549 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 470542..470609 /Source="Nicolas_S_feature" /locus_tag="new_511038_511105" /HighExp="Cold, G150, T-3.40H, HPh, Salt, LPh, G180, G135, Oxctl, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S158" upshifts 470542 /Source="Nicolas_upshifts" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="upshifts" CDS 470661..472145 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16352840, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352840, 27965645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_388339.2" /db_xref="EnsemblGenomes-Gn:BSU04580" /db_xref="EnsemblGenomes-Tr:CAB12265" /db_xref="GOA:P96614" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030880" /db_xref="SubtiList:BG12085" /db_xref="UniProtKB/Swiss-Prot:P96614" /translation="MTITFQDFNLSSDLMKAINRMGFEEATPIQAQTIPLGLSNKDVI GQAQTGTGKTAAFGIPLVEKINPESPNIQAIVIAPTRELAIQVSEELYKIGQDKRAKV LPIYGGQDIGRQIRALKKNPNIIVGTPGRLLDHINRRTIRLNNVNTVVMDEADEMLNM GFIDDIESILSNVPSEHQTLLFSATMPAPIKRIAERFMTEPEHVKVKAKEMTVSNIQQ FYLEVQERKKFDTLTRLLDIQSPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLT QAKRMVALRKFKEGAIEVLVATDVAARGLDISGVTHVYNFDVPQDPESYVHRIGRTGR AGKTGMAMTFITPREKSMLRAIEQTTKRKMDRMKEPTLDEALEGQQQVTVERLRTTIS ENNLNFYMTAAAELLEDHDAVTVVAAAIKMATKEPDDTPVRLTDEAPMVSKRYKNQRS SKRRDGQGGGYRGGKGKSNNRSSYDKKRSNDRRSSGDRRQKKSY*" /label="cshA CDS" gene 470661..472145 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /label="cshA gene" downshifts 472138 /Source="Nicolas_upshifts" /id="D219" /incds=0 /nref=309 /ntot=313 /MaxReadThrough="1.91428" /MaxDrop="8.13079" /score="26.104757" /energy="-13.1" /TU="NA" /idTUdmin="U358" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" S_feature 472258..472317 /Source="Nicolas_S_feature" /locus_tag="new_512754_512813" /HighExp="Etha, LBGexp, G180, Cold, Lbtran, dia0, G150, BMM, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S159" promotor_-35 472258..472267 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 472260 /Source="Nicolas_upshifts" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 472279..472294 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 472318..472797 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388340.1" /db_xref="EnsemblGenomes-Gn:BSU04590" /db_xref="EnsemblGenomes-Tr:CAB12266" /db_xref="GOA:P96615" /db_xref="InterPro:IPR005182" /db_xref="SubtiList:BG12086" /db_xref="UniProtKB/Swiss-Prot:P96615" /translation="MREQPKNQISPDGLKVWRLQEIIISAVCLLIVIAVAVLSYYFHW PYWISGVLGAVWLLGSIVTVFIIPKVRHKVWRYEVHEHEIDIQSGIFVVTRVIVPMVR VQHVDTSQGPLLKKYNLATVKISTAATVHSIPALEMEEADRLRDSISRLARVTDDDV* " /label="ydbS CDS" gene 472318..472797 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /label="ydbS gene" CDS 472787..474268 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388341.1" /db_xref="EnsemblGenomes-Gn:BSU04600" /db_xref="EnsemblGenomes-Tr:CAB12267" /db_xref="GOA:P96616" /db_xref="InterPro:IPR005182" /db_xref="InterPro:IPR014529" /db_xref="SubtiList:BG12087" /db_xref="UniProtKB/Swiss-Prot:P96616" /translation="MMSEPKRLHPVAVILNLCHTIIQTIKNIILPFFFVYIVNSNHTV RFYGAIALGVLFIWLVAASIIKWRRFTYRIEDDEFRIEEGLFVTKKRYISIDRIQTMN TSAGLVQQIFKLVKLQIETAGGGKEAEAVLSAISVEEAERIKEAVFKKKAQRRENELD EERLEAEEELDPSVEVQEHYRMNAKELLMAASTSGGIGVIISAVFALISQLDEVLPMD WLFDKFSFLQHASIGIYAVLIFIGLFIAWIFSIAGMMFRYANFQIIKKEQELVISRGI IEKHQVTIPLRKIQAIKIKENIIRQLFGFVTVSIVSAGGGDREKEEGALTILFPMIHK KKLPHMLRTFTPEYTLEENCRRLPRRALKRYLFRSVIFSLFLIIPLCIFFQPWGYLSV ILLPIELLFGYLAYKEAAWTINGDRLQLTSRFIGRTTAIVLKKRMQVCKFSQSYFQKK GRLYTISTSVKSSSHMEELTVRDVGEEDAAFILKWYSYEKADG*" /label="ydbT CDS" gene 472787..474268 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /label="ydbT gene" downshifts 474238 /Source="Nicolas_upshifts" /id="D220" /incds=0 /nref=6 /ntot=162 /MaxReadThrough="4.90913" /MaxDrop="3.0931" /score="48.2239319" /energy="-17.1" /TU="U363" /idTUdmin="U364" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature 474283..474610 /Source="Nicolas_S_feature" /locus_tag="new_514779_515106" /HighExp="Salt, T0.30H, G135, T1.0H, T1.30H, G150, G180, Oxctl, T-0.40H, aero" /AntisenseName="ydcA" /AntisenseCor="-0.25636523135066602" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S160" downshifts complement(474292) /Source="Nicolas_upshifts" /id="D221" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="0.258529999999999" /MaxDrop="3.15455" /score="-3.74867023" /energy="-8.8" /TU="NA" /idTUdmin="U365" /TUdmin=220 /isTUend="FALSE" /label="downshifts" CDS complement(474520..475119) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /EC_number="3.4.21.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15616571, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhomboid protease" /protein_id="NP_388342.1" /db_xref="EnsemblGenomes-Gn:BSU04610" /db_xref="EnsemblGenomes-Tr:CAB12268" /db_xref="GOA:P96617" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG12088" /db_xref="UniProtKB/Swiss-Prot:P96617" /translation="MFIRTENFQTFIRLYPVVTFILALQAVLWLFFSLPAHSVVLWRD TVTGYNLGVANGEWWRLITPILLHAGFTHLLFNSMSIFLFAPALERMLGKARFLLVYA GSGIIGNIGTYVTEPLDYVHVGASGAIFGLFGVYLFMVLFRNELIGQEHSKMIITLLA FAVLMSFINSNINMMAHLFGLCGGFLLSFLCVQKKERRY*" /label="ydcA CDS" gene complement(474520..475119) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /label="ydcA gene" promotor_-35 474580..474585 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 474598..474617 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 474612..475213 /Source="Nicolas_S_feature" /locus_tag="new_515108_515709" /HighExp="Salt, G135, G150, T0.30H, G180, T1.0H, T1.30H, H2O2, Paraq, Oxctl" /AntisenseName="ydcA" /AntisenseCor="-0.11975373672841701" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S161" upshifts 474612 /Source="Nicolas_upshifts" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(475143..475162) /Source="Nicolas_upshift_promotors" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(475154) /Source="Nicolas_upshifts" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="upshifts" CDS 475214..475579 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /EC_number="2.7.8.7" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11489886, 11525165, 11867633, 12682299, 12926246, 15955059, 16597923; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="holo-acyl carrier protein synthase (phosphopantetheinyl transferase)" /protein_id="NP_388343.1" /db_xref="EnsemblGenomes-Gn:BSU04620" /db_xref="EnsemblGenomes-Tr:CAB12269" /db_xref="GOA:P96618" /db_xref="InterPro:IPR002582" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1F7L" /db_xref="PDB:1F7T" /db_xref="PDB:1F80" /db_xref="SubtiList:BG12089" /db_xref="UniProtKB/Swiss-Prot:P96618" /translation="MIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEK RKNEFLAGRFAAKEAFSKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSQAAVHVS ITHTKEYAAAQVVIERLSS*" /label="acpS CDS" gene 475214..475579 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /label="acpS gene" promotor_-35 475582..475587 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-35" S_feature 475603..475744 /Source="Nicolas_S_feature" /locus_tag="new_516099_516240" /HighExp="S3, S4, BT, LoTm, S5, T5.0H, M9-stat, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S162" promotor_-10 475603..475621 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-10" upshifts 475603 /Source="Nicolas_upshifts" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="upshifts" CDS 475745..476761 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388344.2" /db_xref="EnsemblGenomes-Gn:BSU04630" /db_xref="EnsemblGenomes-Tr:CAB12270" /db_xref="GOA:P96619" /db_xref="InterPro:IPR029046" /db_xref="SubtiList:BG12090" /db_xref="UniProtKB/Swiss-Prot:P96619" /translation="MKKVRKSFVLLLTGLLAVLILSACGQKTQQDIVAGLDEKAKEYT SYKAKAKMTIETGSEPQVYNVEIWHKKPSLYRVYLENPKKDQNQVILRNENGVFVLTP SLNKSFRFQSDWPNNSSQVYLFESLVKDVQNDSDAVFTAKEKKYVFETKTNYQHNKML PTQEITFNKKDMSPSSVKVMDTDRKVMVKVEFSSFEFNKQFDKESFDEKKNMTLSQMD VATSAKPSDTFAVKTPLELPLGVKLLEEKDISTEDGKRIIMTYGGEKSFTLIQEKAQI AKASSSVTLNGEPVNLGYTIGALSDASLSWTYDGVDYLLSSKDLSKEEMVTVAKSMQG QSSK*" /label="ydcC CDS" gene 475745..476761 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /label="ydcC gene" downshifts 476746 /Source="Nicolas_upshifts" /id="D222" /incds=0 /nref=193 /ntot=256 /MaxReadThrough="3.39815" /MaxDrop="6.13946" /score="22.0391647" /energy="-9.5" /TU="U366" /idTUdmin="U363" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 476806..476813 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476827..476846 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476834 /Source="Nicolas_upshifts" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 476876..478045 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /EC_number="5.1.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2835089, 12682299, 15043879, 18399999, 25227915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine racemase" /protein_id="NP_388345.1" /db_xref="EnsemblGenomes-Gn:BSU04640" /db_xref="EnsemblGenomes-Tr:CAB12271" /db_xref="GOA:P10725" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10950" /db_xref="UniProtKB/Swiss-Prot:P10725" /translation="MSTKPFYRDTWAEIDLSAIKENVSNMKKHIGEHVHLMAVVKANA YGHGDAETAKAALDAGASCLAVAILDEAISLRKKGLKAPILVLGAVPPEYVAIAAEYD VTLTGYSVEWLQEAARHTKKGSLHFHLKVDTGMNRLGVKTEEEVQNVMAILDRNPRLK CKGVFTHFATADEKERGYFLMQFERFKELIAPLPLKNLMVHCANSAAGLRLKKGFFNA VRFGIGMYGLRPSADMSDEIPFQLRPAFTLHSTLSHVKLIRKGESVSYGAEYTAEKDT WIGTVPVGYADGWLRKLKGTDILVKGKRLKIAGRICMDQFMVELDQEYPPGTKVTLIG RQGDEYISMDEIAGRLETINYEVACTISSRVPRMFLENGSIMEVRNPLLQVNISN*" /label="alrA CDS" gene 476876..478045 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /label="alrA gene" promotor_-35 477974..477979 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 477994..478012 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 478000 /Source="Nicolas_upshifts" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 478075..478078 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 478094..478113 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 478095 /Source="Nicolas_upshifts" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 478161..478442 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antitoxin EndoAI" /protein_id="NP_388346.1" /db_xref="EnsemblGenomes-Gn:BSU04650" /db_xref="EnsemblGenomes-Tr:CAB12272" /db_xref="GOA:P96621" /db_xref="InterPro:IPR002145" /db_xref="InterPro:IPR010985" /db_xref="InterPro:IPR013321" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12091" /db_xref="UniProtKB/Swiss-Prot:P96621" /translation="MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAY VSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAECEAETTVERLVSGG*" /label="ndoAI CDS" gene 478161..478442 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /label="ndoAI gene" CDS 478447..478797 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 21897862, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 21897862, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease toxin" /protein_id="NP_388347.1" /db_xref="EnsemblGenomes-Gn:BSU04660" /db_xref="EnsemblGenomes-Tr:CAB12273" /db_xref="GOA:P96622" /db_xref="InterPro:IPR003477" /db_xref="InterPro:IPR011067" /db_xref="PDB:1NE8" /db_xref="PDB:4MDX" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12092" /db_xref="UniProtKB/Swiss-Prot:P96622" /translation="MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIV AAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQIRTIDKQRLTDKITHLDDEMMDK VDEALQISLALIDF*" /label="ndoA CDS" gene 478447..478797 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /label="ndoA gene" S_feature complement(478587..479063) /Source="Nicolas_S_feature" /locus_tag="new_519083_519559_c" /HighExp="Etha, Gly, Sw, S8, C30, S6, LBGstat, T0.30H, S7, Salt" /AntisenseName="ndoA" /AntisenseCor="-0.36117231948253697" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigK" /TUshortPSig="1, 1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S163" downshifts complement(478630) /Source="Nicolas_upshifts" /id="D223" /incds=1 /nref=6 /ntot=171 /MaxReadThrough="3.51096" /MaxDrop="3.79912" /score="-8.86444162" /energy="-10.2" /TU="U372" /idTUdmin="U371" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts 478777 /Source="Nicolas_upshifts" /id="D224" /incds=0 /nref=143 /ntot=254 /MaxReadThrough="5.57908" /MaxDrop="5.74865" /score="29.7721113" /energy="-8.9" /TU="U367,U368,U369" /idTUdmin="U366" /TUdmin=799 /isTUend="FALSE" /label="downshifts" promotor_-35 478831..478838 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 478852..478871 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 478860 /Source="Nicolas_upshifts" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 478912..479736 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress" /protein_id="NP_388348.1" /db_xref="EnsemblGenomes-Gn:BSU04670" /db_xref="EnsemblGenomes-Tr:CAB12274" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR014792" /db_xref="InterPro:IPR036513" /db_xref="PDB:2BNL" /db_xref="SubtiList:BG11090" /db_xref="UniProtKB/Swiss-Prot:P42409" /translation="MMSNQTVYQFIAENQNELLQLWTDTLKELSEQESYQLTDQVYEN ISKEYIDILLLSVKDENAAESQISELALRAVQIGLSMKFLATALAEFWKRLYTKMNDK RLPDQESTELIWQIDRFFSPINTEIFNQYSISWEKTVSLQKIALQELSAPLIPVFENI TVMPLVGTIDTERAKRIMENLLNGVVKHRSQVVLIDITGVPVVDTMVAHHIIQASEAV RLVGAKCLLAGIRPEIAQTIVNLGIDLSQVITKNTLQKGIQTALEMTDRKIVSLGE*" /label="rsbRA CDS" gene 478912..479736 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /label="rsbRA gene" promotor_-10 complement(479046..479064) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(479063) /Source="Nicolas_upshifts" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(479065..479664) /Source="Nicolas_S_feature" /locus_tag="new_519561_520160_c" /HighExp="Etha, Sw, Gly, S6, S8, S7, B60, Salt, BT, M9-stat" /AntisenseName="rsbRA" /AntisenseCor="-0.53924606340364201" /AntisenseRegPval="-21" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S164" promotor_-35 complement(479078..479085) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(479653..479671) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(479664) /Source="Nicolas_upshifts" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(479666..480254) /Source="Nicolas_S_feature" /locus_tag="new_520162_520750_c" /HighExp="S6, S8, S7, BT, C30, S5, G135, C90, Gly, Fru" /AntisenseName="rsbS" /AntisenseCor="-0.57706416777859804" /AntisenseRegPval="-24.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S165" promotor_-35 complement(479685..479691) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 479741..480106 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 23320651, 28271471; Product type f : factor" /codon_start=1 /transl_table=11 /product="antagonist of RsbT" /protein_id="NP_388349.1" /db_xref="EnsemblGenomes-Gn:BSU04680" /db_xref="EnsemblGenomes-Tr:CAB12275" /db_xref="GOA:P42410" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11091" /db_xref="UniProtKB/Swiss-Prot:P42410" /translation="MRHPKIPILKLYNCLLVSIQWELDDQTALTFQEDLLNKIYETGA NGVVIDLTSVDMIDSFIAKVLGDVITMSKLMGAKVVLTGIQPAVAVTLIELGIALEEI ETALDLEQGLETLKRELGE*" /label="rsbS CDS" gene 479741..480106 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /label="rsbS gene" CDS 480110..480511 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine-threonine kinase; controlsthe activity of the anxiosome (stressosome)" /protein_id="NP_388350.1" /db_xref="EnsemblGenomes-Gn:BSU04690" /db_xref="EnsemblGenomes-Tr:CAB12276" /db_xref="GOA:P42411" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11092" /db_xref="UniProtKB/Swiss-Prot:P42411" /translation="MNDQSCVRIMTEWDIVAARQLGRNVAKELGFGTVDQARITTAIS ELARNIYLYAGKGQIGIEQVADRGKKGLKIIAEDQGPGIPDIRKVMEDGFSTSGGLGA GLPGVKRLMDEFSLNSVAGEGTEIQAIKWLR*" /label="rsbT CDS" gene 480110..480511 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /label="rsbT gene" promotor_-10 complement(480252..480271) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(480269) /Source="Nicolas_upshifts" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(480285..480294) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 480523..481530 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 17303566, 21979936, 28461450" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 17303566, 21979936, 28461450; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine phosphatase; controls the activity of the anxiosome (stressosome)" /protein_id="NP_388351.1" /db_xref="EnsemblGenomes-Gn:BSU04700" /db_xref="EnsemblGenomes-Tr:CAB12277" /db_xref="GOA:P40399" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014787" /db_xref="InterPro:IPR017944" /db_xref="InterPro:IPR036457" /db_xref="PDB:1W53" /db_xref="PDB:2J6Y" /db_xref="PDB:2J6Z" /db_xref="PDB:2J70" /db_xref="SubtiList:BG11057" /db_xref="UniProtKB/Swiss-Prot:P40399" /translation="MDFREVIEQRYHQLLSRYIAELTETSLYQAQKFSRKTIEHQIPP EEIISIHRKVLKELYPSLPEDVFHSLDFLIEVMIGYGMAYQEHQTLRGIQQEIKSEIE IAANVQQTLLGTKVPQEEALDIGAISVPAKQMSGDYYHFVKDKESINIAIADVIGKGI PAALCMSMIKYAMDSLPETGIHPSQVLKNLNRVVEQNVDASMFITMFYANYNMDKHQF TYASAGHEPGFYYSQKDNTFYDLEAKGLVLGISQDYDYKQFDQHLEKGDMIVLFSDGV TECRTENGFLERPDLQKLIEEHMCSSAQEMVKNIYDSLLKLQDFQLHDDFTLIVLRRK V*" /label="rsbU CDS" gene 480523..481530 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /label="rsbU gene" promotor_-35 481524..481530 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 481545..481563 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 481551 /Source="Nicolas_upshifts" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 481592..481921 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677; Product type f: factor" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of RsbW)" /protein_id="NP_388352.1" /db_xref="EnsemblGenomes-Gn:BSU04710" /db_xref="EnsemblGenomes-Tr:CAB12278" /db_xref="GOA:P17903" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG10733" /db_xref="UniProtKB/Swiss-Prot:P17903" /translation="MNINVDVKQNENDIQVNIAGEIDVYSAPVLREKLVPLAEQGADL RICLKDVSYMDSTGLGVFVGTFKMVKKQGGSLKLENLSERLIRLFDITGLKDIIDISA KSEGGVQ*" /label="rsbV CDS" gene 481592..481921 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /label="rsbV gene" CDS 481918..482400 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 21979936, 27977677; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine kinase and anti-sigma factor (inhibitory sigma-B binding protein)" /protein_id="NP_388353.1" /db_xref="EnsemblGenomes-Gn:BSU04720" /db_xref="EnsemblGenomes-Tr:CAB12279" /db_xref="GOA:P17904" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010193" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10734" /db_xref="UniProtKB/Swiss-Prot:P17904" /translation="MKNNADYIEMKVPAQPEYVGIIRLTLSGVASRMGYTYDEIEDLK IAVSEACTNAVQHAYKEDKNGEVSIRFGVFEDRLEVIVADEGDSFDFDQKQQDLGPYT PSHTVDQLSEGGLGLYLMETLMDEVRVQNHSGVTVAMTKYLNGERVDHDTTIKNYETN *" /label="rsbW CDS" gene 481918..482400 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /label="rsbW gene" CDS 482366..483154 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-37 factor (sigma(B))" /protein_id="NP_388354.2" /db_xref="EnsemblGenomes-Gn:BSU04730" /db_xref="EnsemblGenomes-Tr:CAB12280" /db_xref="GOA:P06574" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014288" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10735" /db_xref="UniProtKB/Swiss-Prot:P06574" /translation="MTQPSKTTKLTKDEVDRLISDYQTKQDEQAQETLVRVYTNLVDM LAKKYSKGKSFHEDLRQVGMIGLLGAIKRYDPVVGKSFEAFAIPTIIGEIKRFLRDKT WSVHVPRRIKELGPRIKMAVDQLTTETQRSPKVEEIAEFLDVSEEEVLETMEMGKSYQ ALSVDHSIEADSDGSTVTILDIVGSQEDGYERVNQQLMLQSVLHVLSDREKQIIDLTY IQNKSQKETGDILGISQMHVSRLQRKAVKKLREALIEDPSMELM*" /label="sigB CDS" gene 482366..483154 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /label="sigB gene" CDS 483154..483753 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine phosphatase" /protein_id="NP_388355.1" /db_xref="EnsemblGenomes-Gn:BSU04740" /db_xref="EnsemblGenomes-Tr:CAB12281" /db_xref="GOA:P17906" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR036457" /db_xref="PDB:3W40" /db_xref="PDB:3W41" /db_xref="PDB:3W42" /db_xref="PDB:3W43" /db_xref="PDB:3W44" /db_xref="PDB:3W45" /db_xref="SubtiList:BG10736" /db_xref="UniProtKB/Swiss-Prot:P17906" /translation="MIQVEENEHIQTLVYQLNKEGKSICGDSFFMKADDKELICAVAD GLGSGSLANESSAAIKDLVENYASEDVESIIERCNQAMKNKRGATASILKINFEQRQF TYCSVGNVRFILHSPSGESFYPLPISGYLSGKPQKYKTHTATYEKGSKFIIHTDGLNV PDIRSHLKKGQSVEEISNSLKMYTTSRKDDLTYILGQLS*" /label="rsbX CDS" gene 483154..483753 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /label="rsbX gene" downshifts 483739 /Source="Nicolas_upshifts" /id="D225" /incds=0 /nref=267 /ntot=278 /MaxReadThrough="2.46753" /MaxDrop="7.92167" /score="1.26147577" /energy="-6" /TU="NA" /idTUdmin="U369" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 483797..483803 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 483818..483837 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" Polymorphism join(483826,483828) /Source="geneious" /ID="SNP_BsDelta6_524323_524323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="A -> C" /Codon_Change /Coverage=183 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="BSU_04745_promoter_down_mutation" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 483830 /Source="Nicolas_upshifts" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 483864..483980 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513945.1" /translation="MWNYEYTAIADVDVGKPGTVIRKQKQWINGRRVLHQIL*" /label="hypothetical protein CDS" gene 483864..483980 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /label="gene" CDS 483996..484289 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388356.1" /db_xref="EnsemblGenomes-Gn:BSU04750" /db_xref="EnsemblGenomes-Tr:CAB12282" /db_xref="SubtiList:BG12093" /db_xref="UniProtKB/Swiss-Prot:P96623" /translation="MERKEHCFCKEKQFSYGLSMWRNIGRFLSWSTCPHSNVIMEFFH VLQKQKEDLCITYGIVLEGAEAKKWGEIIGTELSKDMPTAVSRLVHLYGGVIK*" /label="ydcF CDS" gene 483996..484289 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /label="ydcF gene" promotor_-35 484257..484265 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 484277..484296 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 484286..484726 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388357.1" /db_xref="EnsemblGenomes-Gn:BSU04760" /db_xref="EnsemblGenomes-Tr:CAB12283" /db_xref="InterPro:IPR002740" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR022996" /db_xref="SubtiList:BG12094" /db_xref="UniProtKB/Swiss-Prot:P96624" /translation="MNTNYWIGVVSEQHVLKGAAGGFAQLCHGKKAPLAKMKEGDWLI YYSPRDAYPDGKLLRSFTAIGKVKSGNIYPYQMAPNFIPYRLDIDYYPCHKIGFYDIK SKLEFVQETKHLGFLFRRGHFEISKKDFLTIAQAMGVNISGMAL*" /label="ydcG CDS" gene 484286..484726 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /label="ydcG gene" upshifts 484292 /Source="Nicolas_upshifts" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(484525..487580) /Source="Nicolas_S_feature" /locus_tag="new_525021_528076_c" /HighExp="S6, S8, S7, S5, B36, S4, B60, BT, Pyr, C30" /AntisenseName="ydcI" /AntisenseCor="-0.61304426345041496" /AntisenseRegPval="-28.4" /CDS_PredictionProba="0.40759499999999999" /TUshortSig="SigK" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S166" CDS 484710..485153 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12088660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388358.1" /db_xref="EnsemblGenomes-Gn:BSU04770" /db_xref="EnsemblGenomes-Tr:CAB12284" /db_xref="GOA:P96625" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12095" /db_xref="UniProtKB/Swiss-Prot:P96625" /translation="MEWHSKFSGPNTSPGFLLWQATQSWQRKVGKALAEFDLTHVQFV LLTSCKYMIAHGETVTQKKLASFSQTNIMMVSEVVRTLEKKGFIERSKNPQDKREVLL SLTEIGGEKVTAALPIVEKIDQAFFAAAMKKENFLSGLQELLKHE*" /label="ydcH CDS" gene 484710..485153 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /label="ydcH gene" downshifts 485128 /Source="Nicolas_upshifts" /id="D226" /incds=0 /nref=11 /ntot=147 /MaxReadThrough="2.17786" /MaxDrop="3.86856" /score="21.3746204" /energy="-6.8" /TU="NA" /idTUdmin="U376" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 485184..485185 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-35" promotor_-10 485201..485220 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-10" upshifts 485201 /Source="Nicolas_upshifts" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="upshifts" CDS 485247..487406 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755871, 12910271, 15383836, 16282592; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA helicase transcriptional accessory protein" /protein_id="NP_388359.2" /db_xref="EnsemblGenomes-Gn:BSU04780" /db_xref="EnsemblGenomes-Tr:CAB12285" /db_xref="GOA:O31489" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018974" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR023319" /db_xref="InterPro:IPR023323" /db_xref="InterPro:IPR032639" /db_xref="SubtiList:BG12096" /db_xref="UniProtKB/Swiss-Prot:O31489" /translation="METSALLKQQIAKEIGLSQKHVESVIRLLEDGNTVPFIARYRKE QTGSMDEVQIQTISERWQYIQNLNQRKEEVIRLIAEQDKLTDNLKRKIEQSVKLQEVE DLYRPYKQKRKTKATVAKSKGLEPLADYILTLPQDDHLAATADQYISEEKEVFTREEA IEGAKHIIAEQISDEPTFRKWIRQETFKRGTIKSAAGKSADTDEKNVYEMYYEYEEPI AKVVPHRVLAMNRGEKEDILKVAIEPPADHIKAYLEKQIIKNRSTSVREILQETIEDS YKRLIQPAIEREIRKELSEKADEQAIHIFSENLRKLLLQPPMKGKTVLGVDPAFRTGC KLAVSDETGKVLKIDVIYPHAPVNKTKEAHEKVKKILEQYQVEMVAIGNGTASRETEQ FIVNVLRDMPRKIYYVIVNEAGASVYSASELAREEFPDLKVEERSAVSIARRLQDPLA ELVKIDPKSVGVGQYQHDVSQKRLNESLRFVVETVVNQVGVNVNTASAALLQYVAGLS KSVAGNVVKKREEIGKFSNRKELKDIPRLGAKTYEQCIGFLRVQEGTEPLDRTGIHPE SYKETKALLKKLGLSTEHIGTAELKDKINQLALSETAKELGIGEITLKDICEQLTRPE RDPRDKVPKPLLKTDVLQLEDLKEGMELQGTVRNVVDFGAFVDIGVKQDGLVHISKLS NQFVKHPLDVVSVGDIVTVWVDGVDVQKGRVSLSMVK*" /label="tex CDS" gene 485247..487406 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /label="tex gene" misc_feature 487394..487413 /Source="Nicolas_upshift_promotors" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 487416..487632 /Source="Nicolas_S_feature" /locus_tag="new_527912_528128" /HighExp="Cold, Etha, LBGstat, dia5, LPhT, T4.0H, dia15, T3.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S167" upshifts 487416 /Source="Nicolas_upshifts" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="upshifts" CDS complement(487416..487529) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /function="16.3: Control" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:22463703, 26387458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22463703, 26387458; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor allowing degradation of SpoIVA by ClpXP" /protein_id="YP_009513946.1" /translation="MPNWLKKQMQKAFLEKDNYQIKLLNQCWYFYRKKHCS*" /label="cmpA CDS" gene complement(487416..487529) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /label="cmpA gene" promotor_-10 complement(487569..487588) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(487586) /Source="Nicolas_upshifts" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(487603..487611) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-35" CDS 487633..488085 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388360.1" /db_xref="EnsemblGenomes-Gn:BSU04790" /db_xref="EnsemblGenomes-Tr:CAB12286" /db_xref="GOA:P96628" /db_xref="InterPro:IPR006640" /db_xref="InterPro:IPR023524" /db_xref="InterPro:IPR035240" /db_xref="SubtiList:BG12098" /db_xref="UniProtKB/Swiss-Prot:P96628" /translation="MDNKELQKLTEDISETYFKKPFRHQALFNDRLKTTGGRYLLTSH NIELNRKYLIEHGREELIGIIKHELCHYHLHLEGKGYKHRDRDFRMLLQQVNAPRFCT PLKKKAENKKTYMYICTTCGQQYIKKRAMNPDRYRCGKCRGKIKRIFS*" /label="ydcK CDS" gene 487633..488085 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /label="ydcK gene" promotor_-35 488091..488097 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488112..488131 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 488120..488207 /Source="Nicolas_S_feature" /locus_tag="new_528616_528703" /HighExp="C30, LBGstat, Cold, UNK1, GM 25, GM 120, GM 15, Heat, T-3.40H, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S168" upshifts 488120 /Source="Nicolas_upshifts" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(488152) /Source="Nicolas_upshifts" /id="D227" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="2.50342" /MaxDrop="3.97305" /score="8.78044068" /energy="-9.2" /TU="NA" /idTUdmin="U381" /TUdmin=704 /isTUend="FALSE" /label="downshifts" tRNA 488208..488282 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Asn tRNA" gene 488208..488282 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /label="trnS-Asn gene" tRNA 488287..488377 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Ser tRNA" gene 488287..488377 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /label="trnS-Ser gene" tRNA 488407..488478 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Glu tRNA" gene 488407..488478 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /label="trnS-Glu gene" tRNA 488490..488564 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Gln tRNA" gene 488490..488564 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /label="trnS-Gln gene" tRNA 488591..488666 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Lys tRNA" gene 488591..488666 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /label="trnS-Lys gene" tRNA 488678..488759 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu1 tRNA" gene 488678..488759 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /label="trnS-Leu1 gene" downshifts 488824 /Source="Nicolas_upshifts" /id="D228" /incds=0 /nref=3 /ntot=136 /MaxReadThrough="6.94232" /MaxDrop="3.5424" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA 488840..>488925 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu (GAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu2 tRNA" gene 488840..>488925 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /modified_by="User" /label="trnS-Leu2 gene" SCAR 488925..488926 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="Delta6_2" S_feature complement(<488926..489232) /Source="Nicolas_S_feature" /locus_tag="new_549923_550239_c" /HighExp="Diami, dia15, dia5, HPh, Etha, H2O2, Cold, LPh, C90, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /modified_by="User" /label="S175" downshifts 488945 /Source="Nicolas_upshifts" /id="D238" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="0.144629999999999" /MaxDrop="3.58923" /score="4.45688042" /energy="-12.2" /TU="NA" /idTUdmin="U389" /TUdmin=84 /isTUend="FALSE" /label="downshifts" downshifts complement(488977) /Source="Nicolas_upshifts" /id="D239" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.31925" /MaxDrop="3.67068" /score="-2.66780619" /energy="-18.7" /TU="NA" /idTUdmin="U391" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(489233..490252) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /EC_number="1.14.14.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_388385.1" /db_xref="EnsemblGenomes-Gn:BSU05040" /db_xref="EnsemblGenomes-Tr:CAB12311" /db_xref="GOA:P96651" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12121" /db_xref="UniProtKB/Swiss-Prot:P96651" /translation="MKKFDISVLSVAPLRQGETMKQGIDSAVSLAKAVDNMGYKRIWF AEHHNHDAYASAATVSIVQHILANTKDIRVGSGGIMLPNHSPLIVAEQFGTLETLYPN RVDLALGRAPGTDQKTADVIRRSNHNGVFFFEREVNDILRFVGDKSVQGEVRAYPGIG THVPVFVLGSSTDSAEIAAKLGLPYAFGAQFSPHSMEEALSIYRENFQPSSYLQEPYV IACINVIAAESIDEASFISASHLQVYIDIYTNNLSKLIPPTENFLESLSQFELEILHS RLGYTIMGDRETIRRELIDFQQMYHADELIVLSNIYELSKEIQSYEILKQVVDELFKK RMEQL*" /label="yddN CDS" gene complement(489233..490252) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /label="yddN gene" promotor_-10 complement(489928..489947) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(489941) /Source="Nicolas_upshifts" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(489962..489969) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 490041..490045 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 490062..490081 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 490066 /Source="Nicolas_upshifts" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="upshifts" S_feature 490067..490511 /Source="Nicolas_S_feature" /locus_tag="new_551074_551518" /HighExp="dia15, dia5, H2O2, G180, G135, Paraq, HPh, LBGexp, Lbexp, G150" /AntisenseName="yddN" /AntisenseCor="0.70327972625798696" /AntisenseRegPval="-40.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S176" CDS 490512..490922 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388386.1" /db_xref="EnsemblGenomes-Gn:BSU05050" /db_xref="EnsemblGenomes-Tr:CAB12312" /db_xref="GOA:P96652" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12122" /db_xref="UniProtKB/Swiss-Prot:P96652" /translation="MIDEIDKKILDELSKNSRLTMKKLGEKVHLTAPATASRVVKLID NGIIKGCSIEVNQVKLGFSIHAFLNIYIEKIHHQPYLAFIETQDNYVINNYKVSGDGC YLLECKFPSNEVLDQFLNDLNKHANYKVSIVIGK*" /label="lrpA CDS" gene 490512..490922 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /label="lrpA gene" S_feature 490923..490992 /Source="Nicolas_S_feature" /locus_tag="new_551930_551999" /HighExp="dia15, dia5, H2O2, HPh, G180, G135, LBGtran, Paraq, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S177" downshifts 490949 /Source="Nicolas_upshifts" /id="D240" /incds=0 /nref=45 /ntot=194 /MaxReadThrough="2.99689" /MaxDrop="3.6808" /score="-1.98969146" /energy="-15.7" /TU="U392" /idTUdmin="U392" /TUdmin="-350" /isTUend="FALSE" /label="downshifts" CDS complement(491045..491494) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388387.1" /db_xref="EnsemblGenomes-Gn:BSU05060" /db_xref="EnsemblGenomes-Tr:CAB12313" /db_xref="GOA:P96653" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12123" /db_xref="UniProtKB/Swiss-Prot:P96653" /translation="MQIDSIDFQILQLLNKNARIQWKEIGEKIHMTGQAVGNRIKKME DNGIIKAYSIVVDELKMGFSFTAFVFFFMNAYMHDDLLKFIATRNEISEAHRVSGDAC YLLKVTVHSQEVLNHLLNDLLKYGNYQLYLSIKEVKKHYNTSLMSDE*" /label="lrpB CDS" gene complement(491045..491494) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /label="lrpB gene" CDS 491609..492151 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388388.1" /db_xref="EnsemblGenomes-Gn:BSU05070" /db_xref="EnsemblGenomes-Tr:CAB12314" /db_xref="GOA:P96654" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12124" /db_xref="UniProtKB/Swiss-Prot:P96654" /translation="MTTALLVIDIQNDYFPNGKMALTNPEKAAQNAAKLLSHFRNTGA PVFHVQHITEGNIAHFFHPNTEGVEIHESVRPLEKETVIVKHMPNSFFNTDLNGKLQE EGVKELVVCGMMSHMCIDATVRSAVEHGYVCQVVEDACATTTLQIEDKIVPAEHVHYA FMAALNGVYATVKTTEAFLK*" /label="yddQ CDS" gene 491609..492151 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /label="yddQ gene" promotor_-35 492624..492628 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492645..492664 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 492654 /Source="Nicolas_upshifts" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="upshifts" CDS 492704..493468 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388389.1" /db_xref="EnsemblGenomes-Gn:BSU05080" /db_xref="EnsemblGenomes-Tr:CAB12315" /db_xref="GOA:P96655" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12125" /db_xref="UniProtKB/Swiss-Prot:P96655" /translation="MNITQIRNATIVVKYANKKFLIDPMLAEKGTYATFPETIRQDLF NPLVSLPTSIDNILDGVDAVIVTHLHLDHFDDVAKNVLPKNIKMFVQNEADAKEVKAS GFKNVEVLHQDTVFEGIQLVKTKGEHGRGEELLNLMGDVCGLVFKHPSEKVLYVAGDT VWYDAIEDEIHTHQPEIIVVNGGDNQRLDLGSLIMGKEDIYEVHKAAPHAKIISVHME AVNHWTLSREELKNFSKEKGFSSNILVPEDGESYTF*" /label="yddR CDS" gene 492704..493468 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /label="yddR gene" CDS 493662..494972 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388390.1" /db_xref="EnsemblGenomes-Gn:BSU05090" /db_xref="EnsemblGenomes-Tr:CAB12316" /db_xref="GOA:P96656" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12126" /db_xref="UniProtKB/Swiss-Prot:P96656" /translation="MVMTKKDTNISTQQPLWLQGYIDSPEKQNQLYKKTLKILIFSQI FGGAGLGAGITVGALLAQDMIGSENVAGIPTALFTFGSAVAALLIGASSQRFGRRAGL AGGFLIGGLGAIGVIIAALINSVALLFVSLLIYGAGMASNLQVRYAGTDLANEKQRAT AASMALVSTTLGAVVGPNLVNTMGEFADSIGVPNLAGPFIMSGAAFIIAGIILLIFLR PDPLFVSTAIANAEKKDDKVQIGGSLKNPAIDKKGIMVGAVIMILAQLIMTAIMTMTP VHMGHHGHGLSEVGLVIGLHIAAMYLPSPLTGLLVDKFGRTTMAIASGATLLAAGLVA AIAPADSLSLLILALVLLGVGWNFGLLTGTALIIDSTHPSLRAKTQGTFDVLLALSGA AGGALSGMVVAHSSYTILSISGAVLSLLLIPVVIWYFRRIQEKA*" /label="yddS CDS" gene 493662..494972 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /label="yddS gene" S_feature 494995..495554 /Source="Nicolas_S_feature" /locus_tag="new_556002_556561" /HighExp="S8, C30, Cold, BMM, C90, GM 25, MG 15, M/G, LPh, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S178" CDS 495555..495731 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved phage protein of unknown function" /protein_id="YP_003097682.1" /db_xref="EnsemblGenomes-Gn:BSU05099" /db_xref="EnsemblGenomes-Tr:CAX52553" /db_xref="GOA:Q9K3A9" /db_xref="UniProtKB/Swiss-Prot:Q9K3A9" /translation="MNNKKNIFDIVMYIIFGVLSLFLVAKTDYGTGVLVFVAILYLAV IAYKIKQVFSNSDS*" /label="ydzM CDS" gene 495555..495731 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /label="ydzM gene" CDS 495756..496442 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported phage protein" /protein_id="NP_388391.1" /db_xref="EnsemblGenomes-Gn:BSU05100" /db_xref="EnsemblGenomes-Tr:CAB12317" /db_xref="SubtiList:BG12127" /db_xref="UniProtKB/Swiss-Prot:P96657" /translation="MRKKRVITCVMAASLTLGSLLPAGYASAKEDSKTTPSYEELALH YKMKSEKISSNGKLVEIEYVSGNETHKVQMNGNNHTVKVDGIEQKGLNFEYDENVAKR TNYENNNLKSNEFTTQAAKPKKGYHYVGTLSGHTKAAKNALSVTMSLVGIVPGLGWGS KAATILFSYWAKEQIPDAYYKYDLYEKGAMTDSWYQYATVQFFEDKAHKKKMGKPWTS TPAKVDLPNS*" /label="yddT CDS" gene 495756..496442 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /label="yddT gene" promotor_-35 496784..496788 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-35" promotor_-10 496803..496822 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-10" upshifts 496811 /Source="Nicolas_upshifts" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="upshifts" Polymorphism join(496858,496860) /Source="geneious" /ID="SNP_BsDelta6_557866_557865" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)5 -> (T)6" /Codon_Change /Coverage=35 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value="3.2e-123" /Variant_Raw_Frequency=35 /comment="ydzN_translation_signal_variant" /modified_by="User" / /label="Polymorphism_Delta6" CDS 496867..497052 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097683.1" /db_xref="EnsemblGenomes-Gn:BSU05109" /db_xref="EnsemblGenomes-Tr:CAX52554" /db_xref="GOA:C0H3V7" /db_xref="UniProtKB/Swiss-Prot:C0H3V7" /translation="MRWSKWFNVFCIVALGSIYGYKLFTNQEVSTTRLIIASVIVLWN IVGLFSKESVKQAQQAN*" /label="ydzN CDS" gene 496867..497052 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /label="ydzN gene" downshifts 497051 /Source="Nicolas_upshifts" /id="D241" /incds=0 /nref=9 /ntot=125 /MaxReadThrough="3.39785" /MaxDrop="3.7067" /score="-6.31330934" /energy="-12.8" /TU="U394" /idTUdmin="U394" /TUdmin="-1068" /isTUend="FALSE" /label="downshifts" CDS 497402..497995 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /experiment="publication(s) with functional evidences, PMID:24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase III homolog, deglycase" /protein_id="NP_388392.1" /db_xref="EnsemblGenomes-Gn:BSU05110" /db_xref="EnsemblGenomes-Tr:CAB12318" /db_xref="GOA:P96658" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="PDB:3F5D" /db_xref="SubtiList:BG12128" /db_xref="UniProtKB/Swiss-Prot:P96658" /translation="MKKALFLILDQYADWEGVYLASALNQREDWSVHTVSLDPIVSSI GGFKTSVDYIIGLEPANFNLLVMIGGDSWSNDNKKLLHFVKTAFQKNIPIAAICGAVD FLAKNGLLNNHSHTGNFVYLWKDYKQYKPISSFVEKQAVRDKNLVTANGTAPIEFTNL ILEMIDFDTPENIEKMMYMNRYGFYHFCDKYGNPFVD*" /label="sufLC CDS" gene 497402..497995 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /label="sufLC gene" promotor_-35 498108..498115 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 498129..498148 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 498140..498257 /Source="Nicolas_S_feature" /locus_tag="new_559146_559263" /HighExp="B60, LoTm, T5.0H, T3.30H, M9-stat, BI, BC, C90, T3.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S179" upshifts 498140 /Source="Nicolas_upshifts" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(498175) /Source="Nicolas_upshifts" /id="D242" /incds=0 /nref=10 /ntot=93 /MaxReadThrough="1.86628" /MaxDrop="4.19111" /score="25.1917407" /energy="-12.9" /TU="NA" /idTUdmin="U396" /TUdmin=328 /isTUend="FALSE" /label="downshifts" CDS 498258..498458 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9379903, 9914312, 9920884, 10517332, 11591689, 12427936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379903, 9914312, 9920884, 10517332, 11591689, 12427936; Product type f : factor" /codon_start=1 /transl_table=11 /product="cold-shock protein" /protein_id="NP_388393.1" /db_xref="EnsemblGenomes-Gn:BSU05120" /db_xref="EnsemblGenomes-Tr:CAB12319" /db_xref="GOA:P39158" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11024" /db_xref="UniProtKB/Swiss-Prot:P39158" /translation="MEQGTVKWFNAEKGFGFIERENGDDVFVHFSAIQSDGFKSLDEG QKVSFDVEQGARGAQAANVQKA*" /label="cspC CDS" gene 498258..498458 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /label="cspC gene" S_feature complement(498356..499144) /Source="Nicolas_S_feature" /locus_tag="new_559362_560150_c" /HighExp="LoTm, B60, Cold, M9-stat, LPhT, B36, Sw, BC, S8, Salt" /AntisenseName="cspC" /AntisenseCor="0.39074308987975698" /AntisenseRegPval="-10.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S180" downshifts 498361 /Source="Nicolas_upshifts" /id="D243" /incds=1 /nref=19 /ntot=179 /MaxReadThrough="8.05368" /MaxDrop="3.4464" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 498462 /Source="Nicolas_upshifts" /id="D244" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="5.78621" /MaxDrop="5.83905" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=343 /isTUend="FALSE" /label="downshifts" misc_RNA complement(498526..498604) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /product="putative small conserved untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sncZ RNA" gene complement(498526..498604) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /label="sncZ gene" CDS complement(499145..499606) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26849219; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for repair and outgrowth of heat damaged spores" /protein_id="NP_388394.1" /db_xref="EnsemblGenomes-Gn:BSU05130" /db_xref="EnsemblGenomes-Tr:CAB12320" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG12129" /db_xref="UniProtKB/Swiss-Prot:P96659" /translation="MFQIGDNIVYPMHGAGIIEAIEEKEFLEEKQQYYVIRMSISNMT VMIPTSKILSSNIRPVTDILALKHIMHIFQHGESDRLLPWKQRYKINTDKIKTGEIQE GAEVVRDLMRMKKEKALNASEKKMLDNAYEFLISELEVIKGITEKQIKSFG*" /label="cdnL CDS" gene complement(499145..499606) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /label="cdnL gene" S_feature 499615..500160 /Source="Nicolas_S_feature" /locus_tag="new_560621_561166" /HighExp="Cold, G135, S8, G180, LoTm, S7, G150, HPh, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S181" upshifts complement(499658) /Source="Nicolas_upshifts" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(499665..499684) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(499700..499707) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 500127 /Source="Nicolas_upshifts" /id="D245" /incds=0 /nref=7 /ntot=141 /MaxReadThrough="0.289110000000001" /MaxDrop="4.3701" /score="26.1823933" /energy="-9.5" /TU="NA" /idTUdmin="U395" /TUdmin=864 /isTUend="FALSE" /label="downshifts" CDS complement(500174..500410) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388395.1" /db_xref="EnsemblGenomes-Gn:BSU05140" /db_xref="EnsemblGenomes-Tr:CAB12321" /db_xref="GOA:O31493" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12808" /db_xref="UniProtKB/Swiss-Prot:O31493" /translation="MYLGIVSTACAFLLWNHGLQLLNASSGGLFFFFQPLVGTLLGWI LLGEQIGGTFWIGSFLILSGVLLVIKEKEKEVKS*" /label="ydzE CDS" gene complement(500174..500410) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /label="ydzE gene" CDS complement(500508..501383) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388396.1" /db_xref="EnsemblGenomes-Gn:BSU05150" /db_xref="EnsemblGenomes-Tr:CAB12322" /db_xref="GOA:P96660" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG12130" /db_xref="UniProtKB/Swiss-Prot:P96660" /translation="MKNFVIDQNLKELTEHRTVELPVACYKTTINQNINGYIPLHWHD EIQFVLILKGIALFQINEEKIEVHEGDGLFINSGYLHMAEEKEGSDCTYICLNVSPHF VLSQELYSSYVQPYMFSTNLPYLFLAGNQQWAKNILDAVKKINQLIQQKTSLYEIDIT MQLTLMWKNLVVNGFQLEYDQSEMIKSHRMKQMLNWIHLHYVEKITLEDIAKAGQLSR SECCRYFKRMLNKTPLRYVMDYRIQKSLLLLQHPESNVTEVSYQVGFNSTSYFISKFQ QAMNMTPLSYKKMNS*" /label="ydeC CDS" gene complement(500508..501383) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /label="ydeC gene" CDS 501496..502455 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388397.1" /db_xref="EnsemblGenomes-Gn:BSU05160" /db_xref="EnsemblGenomes-Tr:CAB12323" /db_xref="GOA:P96661" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12131" /db_xref="UniProtKB/Swiss-Prot:P96661" /translation="MNTSNRRMGLFYVITGATCWGIGGTVAKKLFQEYQIDVNWLVTT RLLTAGMLLLMLQLFRKDRSQVIEVWKHKASAGQLLIFGLLGMLAVQYTYMASIQHGN AAVATLLQYLSPVIVIIYTLLRKQTVLTKQDIITVVLALVGCFFLLTNGSMSQLSVPA AAVVWGVLSGFAAAFYTLYAVGLLNKFDSLVVVGWAMIIGGFALGFIHPPWQLDFQRL TAEAYAYILFVILFGTMIAFWFFIKSLESLSPKETSLLGSLEPLSAVVTTVVWLKAPF GSFQWIGAICIIGITLILALHKEPSMESEKSILKIRNHANRDI*" /label="ydeD CDS" gene 501496..502455 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /label="ydeD gene" upshifts complement(501517) /Source="Nicolas_upshifts" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(501521..501540) /Source="Nicolas_upshift_promotors" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(502608..503480) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388398.1" /db_xref="EnsemblGenomes-Gn:BSU05170" /db_xref="EnsemblGenomes-Tr:CAB12324" /db_xref="GOA:P96662" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12132" /db_xref="UniProtKB/Swiss-Prot:P96662" /translation="MDLLKSMNRALKYIEENLTNDIDFQEAAKLAFCSEYHFKRMFSF LAGISLSEYIRRRRLTLAAFELKDSNVKVIDIAIKYGYNSPDSFARAFQNLHGINPSK ARFNGHSLKAYPRMTFQLTIKGGNEMNYRIEEKEAFRIVGIKKRVPIIFKGINPEIAS MWESLDEKAINKLKELSNVAPSGLISASTNFSEGRTEENGELDHYIGAATTKRCPDNF SRLEVPASTWAVFESIGPFPDTLQEVWGRIYSEWFPSSNYEQIEGPEILWNEHKDVTS PSFKSEIWIPITKK*" /label="ydeE CDS" gene complement(502608..503480) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /label="ydeE gene" promotor_-10 complement(503573..503578) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(503580..503581) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(503585) /Source="Nicolas_upshifts" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 503654..503660 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 503668 /Source="Nicolas_upshifts" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 503674..503693 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 503707..505095 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388399.2" /db_xref="EnsemblGenomes-Gn:BSU05180" /db_xref="EnsemblGenomes-Tr:CAB12325" /db_xref="GOA:P96663" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12133" /db_xref="UniProtKB/Swiss-Prot:P96663" /translation="MPINSFENYPMSWKPSIDKAEKPIYKALAGQLEQDILNGVLLPG TKLPPQRELADYLDLNVSTISKAFKVCELKGLLSATVGSGTFVSYDALSNAYLLEDTK PTHLIEMGAILPDHASYEPLLYQLKNMVHEEDYEKWFSYGRAGESLWQKDAAVKLIQR GGFETSVDHILFANGGQNAIAATLASLCKPGDRIGVDHHTYPGLKTVASLLSVQIVPI KSENDEMSPESLEYACKNENIKGLYLIPDYHNPTTSFMSVENRRMVADIVKKYNLFVI EDASYHLLNKNPLPALASFAPQQVIHIASLSKSLAPGLRLAYVAVPRQYKEPISKALY NLNITVSPLLAELTARTIVSNQFEVLIESHREQTIRRNQLVNRYVAGYTCLGVETGIF RWLLLPGKMSGAEFEELAARLGVQVYAAERFVVGNSCPERAVRVSVCAPKTLEELEQG LMILRRLLDDLT*" /label="ydeF CDS" gene 503707..505095 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /label="ydeF gene" downshifts 505071 /Source="Nicolas_upshifts" /id="D246" /incds=0 /nref=2 /ntot=61 /MaxReadThrough="0.91547" /MaxDrop="3.65963" /score="12.298375" /energy="-12.2" /TU="NA" /idTUdmin="U399" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS 505205..506497 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388400.1" /db_xref="EnsemblGenomes-Gn:BSU05190" /db_xref="EnsemblGenomes-Tr:CAB12326" /db_xref="GOA:P96664" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12134" /db_xref="UniProtKB/Swiss-Prot:P96664" /translation="MMLDKDSVKAIDVQTASLQSYISSPEKQKSLYKRTLFVVSISQI FGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGL SAGFMIGGLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANHKQRAT AVSITMVFTTFGAVAGPSLVNVMGDFALSIGVPSLAGPFILAAAAYMLAGVVLFIMLR PDPLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPV HMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAA FAPGESMILLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAA GGALSGMIVAGSSYLALSLIGGILSLLLIPVVVWSRGR*" /label="ydeG CDS" gene 505205..506497 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /label="ydeG gene" promotor_-35 506506..506512 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 506527..506546 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 506534 /Source="Nicolas_upshifts" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="upshifts" S_feature 506545..506655 /Source="Nicolas_S_feature" /locus_tag="new_567551_567661" /HighExp="LoTm, T4.0H, T3.30H, T2.30H, T3.0H, T2.0H, T1.30H, T5.0H, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S182" CDS 506656..507102 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388401.1" /db_xref="EnsemblGenomes-Gn:BSU05200" /db_xref="EnsemblGenomes-Tr:CAB12327" /db_xref="GOA:P96665" /db_xref="SubtiList:BG12135" /db_xref="UniProtKB/Swiss-Prot:P96665" /translation="MNHIKWLSDLKKAGLLALGKGVITLLKRFSLVIVTLMMSIVVVL AAAKESPGDHVISFDEPIILMISIGIVVFLLIPPLVMSFFGNLVVRIISGVYQCFIVF TFLGLIPIGFLIPNGFLTILVSIAGTLVSIASVAVTLCIGKNKKDI*" /label="ydeH CDS" gene 506656..507102 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /label="ydeH gene" downshifts 507131 /Source="Nicolas_upshifts" /id="D247" /incds=0 /nref=200 /ntot=251 /MaxReadThrough="2.56495" /MaxDrop="6.50538" /score="-1.7193297" /energy="-4.5" /TU="NA" /idTUdmin="U400" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 507182..507189 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 507204..507223 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 507205 /Source="Nicolas_upshifts" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="upshifts" CDS 507339..507932 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16390439" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388402.1" /db_xref="EnsemblGenomes-Gn:BSU05210" /db_xref="EnsemblGenomes-Tr:CAB12328" /db_xref="InterPro:IPR014922" /db_xref="InterPro:IPR016786" /db_xref="SubtiList:BG12136" /db_xref="UniProtKB/Swiss-Prot:P96666" /translation="MTNSRTNPKVDEFLSKAKKWKEEFEKLRTIILDCELTEDFKWMH PCYTYHNKNIVLIHGFKEYCALLFHKGVLLQDTDGILIQQTENVQAARQIRFTNVQEI NELENILKAYIHEAIEVEKAGLKVDVNKNIELNIPEELQNKFDEIPALKIAFEALTPG RQRAYTLYFSQAKQSKTRESRVEKYVQKILDGKGLKD*" /label="ydeI CDS" gene 507339..507932 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /label="ydeI gene" downshifts 507975 /Source="Nicolas_upshifts" /id="D248" /incds=0 /nref=2 /ntot=40 /MaxReadThrough="1.63432" /MaxDrop="2.96785" /score="2.93671425" /energy="-6.9" /TU="NA" /idTUdmin="U401" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(508051) /Source="Nicolas_upshifts" /id="D249" /incds=0 /nref=1 /ntot=64 /MaxReadThrough="2.19009" /MaxDrop="2.9369" /score="-1.28013562" /energy="-6.9" /TU="NA" /idTUdmin="U403" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 508064..508071 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 508085 /Source="Nicolas_upshifts" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 508086..508105 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(508284..508943) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388403.1" /db_xref="EnsemblGenomes-Gn:BSU05220" /db_xref="EnsemblGenomes-Tr:CAB12329" /db_xref="GOA:P96667" /db_xref="SubtiList:BG12137" /db_xref="UniProtKB/Swiss-Prot:P96667" /translation="MKKRRKICYCNTALLLMILLAGCTDSKDGEAQQPSNQASAVQTD EKHTEPEESTKIRKDEAEPITESEESATKAANDTSSAEEKSKEDNVLAAYSSEKIEYA RVWLQLGPNQEIDELNVRHIAAGEPINPNDDTSASYPENVTQLAGSRLVDGSVTYHGN GDGTIHVYNVPLRWDSADDIEKGVMREVTESIIKNRKTVYVDTGDDEKIKRLIDIMMI H*" /label="ydeJ CDS" gene complement(508284..508943) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /label="ydeJ gene" promotor_-10 complement(508992..509011) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(508999) /Source="Nicolas_upshifts" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(509023..509028) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(509365..510228) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388404.1" /db_xref="EnsemblGenomes-Gn:BSU05230" /db_xref="EnsemblGenomes-Tr:CAB12330" /db_xref="GOA:P96668" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12138" /db_xref="UniProtKB/Swiss-Prot:P96668" /translation="MNKTTNGWINGFIGVLIFSGSLPATRLAVSDFDPLFLTVCRAAI AGVLAGGLLLIFRQQHPAKRDLISLLVVAFGVVIGFPLLTALALQHVTSAHAIVFIGL LPLATAVFGVLRGGERPRPVFWIFSAAGSLLVAGFALIQGGGSSPLGDAYMLASIVVC GLGYAEGAKLSRRLGNWQVISWALVLSLPLMLPLSFFFTPDSWSAIGVPALLSLAYVS LFSMLIGFVFWYRGLAQGGIAAVGQLQLLQPFFGLLLASVILHEKVGWALVAVNIAVI MCVAAARRFAK*" /label="ydeK CDS" gene complement(509365..510228) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /label="ydeK gene" promotor_-35 510271..510277 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 510292..510311 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(510293..510312) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 510307 /Source="Nicolas_upshifts" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(510317) /Source="Nicolas_upshifts" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(510327..510334) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 510383..511774 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /function="16.3: Control" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388405.1" /db_xref="EnsemblGenomes-Gn:BSU05240" /db_xref="EnsemblGenomes-Tr:CAB12331" /db_xref="GOA:P96669" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12139" /db_xref="UniProtKB/Swiss-Prot:P96669" /translation="MDITPFLNRTLDIPLYQQLYRYFKENMHRGRIQKGMKLPSKRLL ANQLSISQTTVERAYEQLAAEGYIVSKPRSGWFADYHDSDFAYDRMPSTTPIQQEAEE NKQWIDFHYGNVDSSYFPFSAWRKSMVNSLDQYGHELYRPGHVLGEFELRTLIAEYLY QSRGVHCGPEQVIIGAGNPILLQILCQVFEPNISIGYEDPGYPRARKIFEANRMNIVP IPVDDEGICIQKIKEQQPNLVYVTPSHQFTLGTIMTINRRIQLLKWAAENQSFIIEDD YDGEFRYTGQPVPSLQGLDQHNRVIYMGTFSKSLLPSLRISYMILPSPLLKKGHEITS LYKQTVSCHSQLTLAEFIKNGEWQKHINRMRKLYRKKRAIVLEAVQRELGEHVRIRGE NSGLRILLDVYLPFGEKELIEKAKKHGVKIYPVSLSYQHHPPTKTVSLGFAGVSESDI REGIKKLKAAWKI*" /label="ydeL CDS" gene 510383..511774 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /label="ydeL gene" promotor_-35 511902..511909 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-35" promotor_-10 511920..511939 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-10" upshifts 511934 /Source="Nicolas_upshifts" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="upshifts" CDS 511968..512393 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1556068, 26349822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase" /protein_id="NP_388406.1" /db_xref="EnsemblGenomes-Gn:BSU05250" /db_xref="EnsemblGenomes-Tr:CAB12332" /db_xref="InterPro:IPR002539" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12140" /db_xref="UniProtKB/Swiss-Prot:P96670" /translation="MKLDEFTIGQVFKTKSLKVSKDDIMRFAGEFDPQYMHVDEEKAS KGRFNGIIASGIQTLAISFKLWIEEGFYGDDIIAGTEMNHMTFIKPVYPDDELFTIVE VLDKQPKRNELGILTVLLSTYNQKEVKVFEGELSVLIKR*" /label="ydeM CDS" gene 511968..512393 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /label="ydeM gene" S_feature 512394..513648 /Source="Nicolas_S_feature" /locus_tag="new_573400_574654" /HighExp="G135, H2O2, G150, HiOs, G180, Cold, Paraq, UNK1, MG 15, LBGexp" /AntisenseName="ydeN" /AntisenseCor="0.40423774227585801" /AntisenseRegPval="-11.3" /CDS_PredictionProba="0.127641" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S183" CDS complement(512446..513018) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15159570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alpha/beta hydrolase" /protein_id="NP_388407.1" /db_xref="EnsemblGenomes-Gn:BSU05260" /db_xref="EnsemblGenomes-Tr:CAB12333" /db_xref="GOA:P96671" /db_xref="InterPro:IPR010662" /db_xref="InterPro:IPR029058" /db_xref="PDB:1UXO" /db_xref="SubtiList:BG12141" /db_xref="UniProtKB/Swiss-Prot:P96671" /translation="MTKQVYIIHGYRASSTNHWFPWLKKRLLADGVQADILNMPNPLQ PRLEDWLDTLSLYQHTLHENTYLVAHSLGCPAILRFLEHLQLRKQLGGIILVSGFAKS LPTLQMLDEFTQGSFDHQKIIESAKHRAVIASKDDQIVPFSFSKDLAQQIDAALYEVQ HGGHFLEDEGFTSLPIVYDVLTSYFSKETR*" /label="ydeN CDS" gene complement(512446..513018) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /label="ydeN gene" downshifts complement(512451) /Source="Nicolas_upshifts" /id="D250" /incds=0 /nref=16 /ntot=160 /MaxReadThrough="1.96868" /MaxDrop="3.80195" /score="2.50673989" /energy="-11.3" /TU="NA" /idTUdmin="U407" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(513019..513099) /Source="Nicolas_S_feature" /locus_tag="new_574025_574105_c" /HighExp="dia15, dia5, Diami, Etha, LPhT, Lbtran, Heat, H2O2, Sw, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S184" CDS complement(513100..513429) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388408.1" /db_xref="EnsemblGenomes-Gn:BSU05270" /db_xref="EnsemblGenomes-Tr:CAB12334" /db_xref="GOA:O31494" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12809" /db_xref="UniProtKB/Swiss-Prot:O31494" /translation="MNSLCRSKQAPFEYTLSLIGGKWKMRILYELGCEKTMRYGELKR AMPFITHKMLSAQLKELQTDGLIHRSEVSHTPLKVEYSLSDRGRSLYPLIDEMCKWGM AQGGPHM*" /label="ydzF CDS" gene complement(513100..513429) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /label="ydzF gene" misc_feature complement(513446..513465) /Source="Nicolas_upshift_promotors" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(513463) /Source="Nicolas_upshifts" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="upshifts" misc_feature 513637..513656 /Source="Nicolas_upshift_promotors" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 513650 /Source="Nicolas_upshifts" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="upshifts" CDS 513684..514556 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388409.1" /db_xref="EnsemblGenomes-Gn:BSU05280" /db_xref="EnsemblGenomes-Tr:CAB12335" /db_xref="GOA:P96672" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12142" /db_xref="UniProtKB/Swiss-Prot:P96672" /translation="MNTPKKHKKFKAKMILQIIMVIIGGIIAAYGLETVLIPNSVSDG GVTGLSIVGSQLFNLPLGILIAVINIPFVWLGYKQIGKSFALLSIIGIVSLAAGTSFF HHTPAIIEGDTLLITVVGGIILGFGMGLALRNGGALDGIDMLAVLLSRKLPFGTSDLI LFLNLFVFIFVSTVFGLQGALLSVIAYYIASKVIHVVEEGLSGSKTFQIITTQPELMV ETIRDQLGRSATYKEAYGGFSHEKFKEITCVINRLEETKLKEIINDIDKTAFVTVYDV AEVKGSNFRNLNHH*" /label="ydeO CDS" gene 513684..514556 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /label="ydeO gene" downshifts 514443 /Source="Nicolas_upshifts" /id="D251" /incds=1 /nref=7 /ntot=181 /MaxReadThrough="3.84278" /MaxDrop="2.68681" /score="15.0132064" /energy="-12.2" /TU="U408" /idTUdmin="U408" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 514641 /Source="Nicolas_upshifts" /id="D252" /incds=0 /nref=54 /ntot=208 /MaxReadThrough="1.19842" /MaxDrop="3.77294" /score="15.0132064" /energy="-12.2" /TU="NA" /idTUdmin="U408" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(514706..515092) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388410.1" /db_xref="EnsemblGenomes-Gn:BSU05290" /db_xref="EnsemblGenomes-Tr:CAB12336" /db_xref="GOA:P96673" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12143" /db_xref="UniProtKB/Swiss-Prot:P96673" /translation="MRNRKLGIDYSSDDFEGCPVETTLDIIGGKWKGILLYHLIDGKK RFNEFRKLYPKITQRMLTLQLRELERDGVIHREVYKQVPPKVEYSLTEFGRTLEPVIL HMKDWGEKYKDRIDKLEAARKAEDKI*" /label="ydeP CDS" gene complement(514706..515092) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /label="ydeP gene" downshifts complement(514718) /Source="Nicolas_upshifts" /id="D253" /incds=0 /nref=29 /ntot=191 /MaxReadThrough="0.85093" /MaxDrop="4.4837" /score="-9.3516261" /energy="-12.9" /TU="NA" /idTUdmin="U409" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(515093..515157) /Source="Nicolas_S_feature" /locus_tag="new_576099_576163_c" /HighExp="Diami, dia5, Salt, dia15, Etha, Heat, G180, HiOs, LBGexp, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S185" promotor_-35 515145..515152 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(515146..515165) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(515159) /Source="Nicolas_upshifts" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 515166..515185 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 515169 /Source="Nicolas_upshifts" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(515180..515187) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 515203..515796 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /EC_number="1.6.99.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase involved in regulating potassium efflux" /protein_id="NP_388411.1" /db_xref="EnsemblGenomes-Gn:BSU05300" /db_xref="EnsemblGenomes-Tr:CAB12337" /db_xref="GOA:P96674" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12144" /db_xref="UniProtKB/Swiss-Prot:P96674" /translation="MDHMKTLVLVVHPNIESSRINKKWKEAVLSEPDVTVHDLYEKYR DQPIDVEFEQQQLLAHDRIVFQFPLYWYSSPPLLKQWFDEVFTFGWAHGPGGNKLKGK EWVTAMSIGSPEHSYQAGGYNLFSISELTKPFQASAHLVGMTYLPSFAEYRANTISDQ EIAESANRYVKHITNIELNPKVRLQRYLKQLESVDLT*" /label="ydeQ CDS" gene 515203..515796 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /label="ydeQ gene" CDS complement(515940..517127) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388412.1" /db_xref="EnsemblGenomes-Gn:BSU05310" /db_xref="EnsemblGenomes-Tr:CAB12338" /db_xref="GOA:P96675" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12145" /db_xref="UniProtKB/Swiss-Prot:P96675" /translation="MANGNKQAGQRISPSLTLLLATACGIIVANLYYAQPLVGLISKA IGLSPSGAGLIVTLTQIGYVAGLLFLVPLGDIIENKKLIVVSLLLSAAALTLTAFVKH GTLFLAAAFFVGLGSIAAQVLVPFASYLASDAARGRVVGNVMSGLLLGIMLSRPISSL VADIWGWNAIFALSAVVSVILAIVLSKVLPARKPTANTNYTALLGSMWKLLRTTPVLR RRAIYHAFVFGAFSLFWTTVPLLLSGPDFHFSQKAIALYALVGIAGAVTAPIGGRLAD RGLTRLATGIALGVVVVSLLLPLMIQSSSPVGITVLVAAAILLDMGVSANLVLSQRAI FSLAPEIRSRLNGLFMAIFFLGGAIGSSIGGWAYASGGWSTALWIGIAFPVIALLYFI TEK*" /label="ydeR CDS" gene complement(515940..517127) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /label="ydeR gene" promotor_-35 517263..517267 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 517281 /Source="Nicolas_upshifts" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 517282..517301 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 517331..517927 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15944459; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388413.1" /db_xref="EnsemblGenomes-Gn:BSU05320" /db_xref="EnsemblGenomes-Tr:CAB12339" /db_xref="GOA:P96676" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011075" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12146" /db_xref="UniProtKB/Swiss-Prot:P96676" /translation="MQSKRGRPRDEGTHKAILSAAYDLLLEKGFDAVTVDKIAERAKV SKATIYKWWSNKAAVIMDSFLSTATDRLPVPDTGSSVQDIVTHATNLARFLTSREGTV IKELIGAGQLDEKLAEEYRTRFFQPRRLQAKGLLEKGIQKGELRENLDIEVSIDLIYG PIFYRLLITGDEVNDSYVRDLVMNAFKGVQATSATESM*" /label="ydeS CDS" gene 517331..517927 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /label="ydeS gene" CDS 518041..518226 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097684.1" /db_xref="EnsemblGenomes-Gn:BSU05329" /db_xref="EnsemblGenomes-Tr:CAX52555" /db_xref="UniProtKB/Swiss-Prot:C0H3V9" /translation="MSKKKSFNREYITSYYYIPFHRLEQGFYTSMEYRKVGVFKQQGK IDGHYVGVMAMEKILAM*" /label="ydzO CDS" gene 518041..518226 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /label="ydzO gene" downshifts 518205 /Source="Nicolas_upshifts" /id="D254" /incds=0 /nref=5 /ntot=123 /MaxReadThrough="1.06987" /MaxDrop="2.89833" /score="-5.04743481" /energy="-6.3" /TU="NA" /idTUdmin="U411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 518338..518341 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 518348..518534 /Source="Nicolas_S_feature" /locus_tag="new_579354_579540" /HighExp="LBGstat, G180, LBGexp, G135, Paraq, G150, Oxctl, dia0, Diami, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S186" upshifts 518348 /Source="Nicolas_upshifts" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 518356..518375 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 518535..518870 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15948947, 16430705" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16430705; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (metals sensing ArsR-SmtB repressors family)" /protein_id="NP_388414.1" /db_xref="EnsemblGenomes-Gn:BSU05330" /db_xref="EnsemblGenomes-Tr:CAB12340" /db_xref="GOA:P96677" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12147" /db_xref="UniProtKB/Swiss-Prot:P96677" /translation="MTIDVAAMTRCLKTLSDQTRLIMMRLFLEQEYCVCQLVDMFEMS QPAISQHLRKLKNAGFVNEDRRGQWRYYSINGSCPEFDTLQLILHQIDQEDELLNHIK QKKTQACCQ*" /label="aseR CDS" gene 518535..518870 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /label="aseR gene" CDS 518883..520190 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12950922, 14970228, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite/antimonite/H+ antiporter" /protein_id="NP_388415.1" /db_xref="EnsemblGenomes-Gn:BSU05340" /db_xref="EnsemblGenomes-Tr:CAB12341" /db_xref="GOA:P96678" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12148" /db_xref="UniProtKB/Swiss-Prot:P96678" /translation="MTSMILAVFIFLLTLVLVIWQPKNLSIGWSACGGAVLALIAGVV NFHDVLTVTGIVWNATLAFVAIILISLILDNIGFFEWAALHMAKAAKGYGVRMFVYVS LLGAIVAALFANDGAALILTPIVLAMVRALHFNEKLVFPFIIASGFIADTTSLPFVVS NLVNIVSADYFHITFIDYASRMVVPYLFSLLASIIVLYLFFRKSIPKRYDLTEVKKPV EAIKDQNMFRLSWYILGLLLIGYFASEFFSIPVSVVAGSIAIIFLIAAQKSPAVHTKK VVKEAPWAIVFFSIGMYVVVYGVRNAGLTDVLSDVIQAAADQGLFAGTIGMGFIAAIL SSIMNNLPTVMIDALAIAGTDTHGMMREALIYANVIGSDLGPKITPIGSLATLLWLHV LSHKGMKISWGTYFKTGIILTIPTLLITLVGLYIWLLIIHSCF*" /label="arsF CDS" gene 518883..520190 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /label="arsF gene" CDS 520222..520326 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of ydzS" /translation="CTGNSCRSQMAEGWGRKYLGAKWNVYSAGIEAQG*" /label="ydzSn CDS" gene 520222..520326 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /pseudo /label="ydzSn gene" CDS 520335..520448 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of ydzS" /translation="AVKAMKEAGIDISNQTSEKFDDPAKAHGTEEVFPKGP*" /label="ydzSc CDS" gene 520335..520448 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /pseudo /label="ydzSc gene" promotor_-35 520634..520642 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 520653..520671 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 520670 /Source="Nicolas_upshifts" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 520688..521473 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388416.1" /db_xref="EnsemblGenomes-Gn:BSU05350" /db_xref="EnsemblGenomes-Tr:CAB12342" /db_xref="GOA:P96679" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027365" /db_xref="SubtiList:BG12149" /db_xref="UniProtKB/Swiss-Prot:P96679" /translation="MSVLQELTKKKYSSLKTMFDDKYCPTFVYSILDQTIPGAVYADD QTFPKSFFIGTESGIYFIAGDQGNRDFHDFIAGYYEEQVKSSKRFTLFSSSDTWDSVL KPILKDDLNQMRRAAFSYQPKSFKKTLQLPKGLVLKRIDEDIISHSTAFNSAYYEEYW NSVSQFASKGFGFAVLHGNHVVSECTSIFLGHNRAEMDIYTLEEYRGLGLAYCVANRF IAFCMENGIVPSWDCDICNNSSIALAAKLGFKTVTEYTIYYSG*" /label="ydfB CDS" gene 520688..521473 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /label="ydfB gene" downshifts 520735 /Source="Nicolas_upshifts" /id="D255" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="2.67554" /MaxDrop="5.08398" /score="39.1565399" /energy="-19.2" /TU="NA" /idTUdmin="U413" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 521483 /Source="Nicolas_upshifts" /id="D256" /incds=0 /nref=2 /ntot=90 /MaxReadThrough="0.161840000000001" /MaxDrop="3.51451" /score="-0.169292431" /energy="-13.6" /TU="NA" /idTUdmin="U413" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS complement(521530..522450) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid exporter" /protein_id="NP_388417.1" /db_xref="EnsemblGenomes-Gn:BSU05360" /db_xref="EnsemblGenomes-Tr:CAB12343" /db_xref="GOA:P96680" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12150" /db_xref="UniProtKB/Swiss-Prot:P96680" /translation="MRKKTVQIMISHSLMIGLWASAFPGIRAGLEGYTPEHLALFRLL IGSMALLLFAVLTQMRLPDLKDIPAIFLLGFLGFAFYHILLNIGEKTVSAGVASLLVT TAPIFSAMLSRLFYKEHFGFTKWLGSMISLLGVLLIAFGAGDFTYSMSGILVILLAAF SESIYFVFQARYIKKYGFIPFVTFTIWGGTIPMLVFLPGLGEEMMNASISATLSIVYL GLLPTVIPYFALAYVTSFVGASEATLSLYVTPALALIISWLWIGEIPTLLSLLGGVVT VGGVCFTYLKVNKMNKIFITHFSAKRVKKL*" /label="ydfC CDS" gene complement(521530..522450) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /label="ydfC gene" CDS 522583..524031 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388418.1" /db_xref="EnsemblGenomes-Gn:BSU05370" /db_xref="EnsemblGenomes-Tr:CAB12344" /db_xref="GOA:P96681" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12151" /db_xref="UniProtKB/Swiss-Prot:P96681" /translation="MSFPEEKKMKKLPKYRQIVHFIKEKIGNGEWPIGSKIPSQRTLA KDFQVNRSTVITALEELMADGLIEGTMGKGTVVINNTWTLMAKNSAPDWDQYVTSGIQ MPSRKIVQEINQSESNTDLIQLSKGELSAEIFPLAVMKEMMGKVSQHMEAFGYEEPKG YLPLREALSNYLKTIGINVSSSSILIVSGALQALQLISMGLLQRGSTVYLDQPSYLYS LHVFQSAGMKLTGLPMDNEGLLPENVHLTRGERGRAILYTNPCFHNPTGILMSKKRRE EILAVSENTQLPIIEDDIYRELWIDEIPPYPIKTIDKNGHVLYIGSLSKTLSPGLRIG WIVGPEPVIERLSDIKMQTDYGSSSLSQRVAAEWFTSGHYQQHVEKVRQQLKVRRELA LSALETHLKEVATWNIPKGGFFVWIKILPSISMKLLYTKALSKGILINLGSIYAQEKG NYIRLSYAYASLEDLQKGIYELGLMIKELASR*" /label="ydfD CDS" gene 522583..524031 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /label="ydfD gene" CDS complement(524149..524772) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavoprotein" /protein_id="NP_388419.1" /db_xref="EnsemblGenomes-Gn:BSU05380" /db_xref="EnsemblGenomes-Tr:CAB12345" /db_xref="GOA:P96682" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12152" /db_xref="UniProtKB/Swiss-Prot:P96682" /translation="MDIKKQDTRRFKEIKPKIMYYGTSTFLLTTLNEDGTTNISPMSS SWALGHYIILGVGLGGKAIDNLERHKECVINLPGPDLWENVERISSYSGKKSIPPLKK QIGFTYKKEKYEAAGLTPLQSKTVSPTRIKECPIQIEAEVKHIRLPEYESSFAIVETQ ALHFHAEESIILDENHINPSKWSPLIYNFRHYFGLGREVGKTFRSET*" /label="ydfE CDS" gene complement(524149..524772) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /label="ydfE gene" promotor_-10 complement(524796..524815) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 524804..524811 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(524815) /Source="Nicolas_upshifts" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 524826..524845 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 524828 /Source="Nicolas_upshifts" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(524830..524836) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 524862..525542 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388420.1" /db_xref="EnsemblGenomes-Gn:BSU05390" /db_xref="EnsemblGenomes-Tr:CAB12346" /db_xref="GOA:P96683" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12153" /db_xref="UniProtKB/Swiss-Prot:P96683" /translation="MNPNIAKISSLLSDPSRSSILLSLMDGRIHPAGELAYLANIKPQ TASFHLNKLLEAKLISVEKHGRHRYYRLADSDAANVIEQLLHIAPKAKVKSLKESKEK KDLHFARTCYDHLAGYVGVQMAHSLVEQGMLKKVDLNFEVTSEGALFFSKLGINEEQQ RNKRRAFARCCLDWSERQHHIAGALGNALLVRMLEEEWIVRMPKTRAIRITQSGKIAF EKHLNVKI*" /label="ydfF CDS" gene 524862..525542 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /label="ydfF gene" downshifts 525575 /Source="Nicolas_upshifts" /id="D257" /incds=0 /nref=113 /ntot=245 /MaxReadThrough="0.50202" /MaxDrop="4.24716" /score="-7.74889591" /energy="-4.5" /TU="U415" /idTUdmin="U415" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(525622..526065) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388421.1" /db_xref="EnsemblGenomes-Gn:BSU05400" /db_xref="EnsemblGenomes-Tr:CAB12347" /db_xref="GOA:P96684" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR004675" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG12154" /db_xref="UniProtKB/Swiss-Prot:P96684" /translation="MSQRVSYYEIAPEGMKIMMDMEKYTKQSSINRTTRELIKIRVSQ MNGCAFCIDMHTSDARKMGETEQRIYCLHAWNECDFYSPEEKAALELSEHITLIPSKR VPDELYHRVREHYDEEQYVDLVLIINQINSWNRISIAMGNRAASK*" /label="ydfG CDS" gene complement(525622..526065) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /label="ydfG gene" downshifts complement(525627) /Source="Nicolas_upshifts" /id="D258" /incds=0 /nref=10 /ntot=187 /MaxReadThrough="1.76648" /MaxDrop="3.73786" /score="0.225628164" /energy="-10.8" /TU="NA" /idTUdmin="U416" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(526088..526107) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(526112) /Source="Nicolas_upshifts" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(526121..526128) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(526151..526330) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097685.1" /db_xref="EnsemblGenomes-Gn:BSU05408" /db_xref="EnsemblGenomes-Tr:CAX52558" /db_xref="GOA:C0H3W0" /db_xref="UniProtKB/Swiss-Prot:C0H3W0" /translation="MNMYWFLGALLYFLIGTYIFIRVTRDSQSGSWILLALAAPLIIA GYPYFYSKKLLSKRR*" /label="ydzP CDS" gene complement(526151..526330) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /label="ydzP gene" CDS complement(526327..526470) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097686.1" /db_xref="EnsemblGenomes-Gn:BSU05409" /db_xref="EnsemblGenomes-Tr:CAX52559" /db_xref="UniProtKB/Swiss-Prot:C0H3W1" /translation="MKSIDLTILSLKRKGIRTEKVLKNQNPDRLSHMTDKNAQPKSKE KEE*" /label="ydzQ CDS" gene complement(526327..526470) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /label="ydzQ gene" promotor_-35 526421..526423 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 526439..526458 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 526455 /Source="Nicolas_upshifts" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 526738..527961 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YdfI]" /protein_id="NP_388422.1" /db_xref="EnsemblGenomes-Gn:BSU05410" /db_xref="EnsemblGenomes-Tr:CAB12348" /db_xref="GOA:P96685" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12155" /db_xref="UniProtKB/Swiss-Prot:P96685" /translation="MLIRNPFKDKYYSHDRRALNMLALRVPGLAFILMIYIASIVLQF VSGGWSILLLYAFTILIAIFALLHWHSYRWVKKRVILYFAVQGLITFALANLMTGFFI LVIIGLYAFLIGQIIGMADRRRTFLILYLLLLLVINSAYHLHKGEVLHFIVIAAPIMI VIITYAATFFAQVDEKIKAQLTLERLELAHQQVEQLTLQNERQRMARDLHDTLAQGLV SLNMQLDAIHVHLAKGNTERAKEIIQQSMKRVKSTIADARSAIDDLRSKSEEIGVLKE RITSLMDHFIESTGMACLLDYRLHQVLDVRTAENCYYIIGECMTNAAKHAEAKTIWIS IWDDEKGRLHLTVKDNGKGFDVEKGKKKRGHYGLLGIQERVRAINGQFNIKSTKLKGT QIEITVPIQGEMQDE*" /label="ydfH CDS" gene 526738..527961 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /label="ydfH gene" CDS 527954..528595 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YdfH]" /protein_id="NP_388423.1" /db_xref="EnsemblGenomes-Gn:BSU05420" /db_xref="EnsemblGenomes-Tr:CAB12349" /db_xref="GOA:P96686" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12156" /db_xref="UniProtKB/Swiss-Prot:P96686" /translation="MNKVLIVDDHLVVREGLKLLIETNDQYTIIGEAENGKVAVRLAD ELEPDIILMDLYMPEMSGLEAIKQIKEKHDTPIIILTTYNEDHLMIEGIELGAKGYLL KDTSSETLFHTMDAAIRGNVLLQPDILKRLQEIQFERMKKQRNETQLTEKEVIVLKAI AKGLKSKAIAFDLGVSERTVKSRLTSIYNKLGANSRTEAVTIAMQKGILTIDN*" /label="ydfI CDS" gene 527954..528595 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /label="ydfI gene" downshifts 528589 /Source="Nicolas_upshifts" /id="D259" /incds=0 /nref=5 /ntot=147 /MaxReadThrough="1.15378" /MaxDrop="2.65603" /score="8.33575703" /energy="-6.4" /TU="NA" /idTUdmin="U419" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(528622..528641) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(528643) /Source="Nicolas_upshifts" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(528655..528662) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 528703..528708 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 528711..530885 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative proton metabolite efflux transporter" /protein_id="NP_388424.1" /db_xref="EnsemblGenomes-Gn:BSU05430" /db_xref="EnsemblGenomes-Tr:CAB12350" /db_xref="GOA:P96687" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12157" /db_xref="UniProtKB/Swiss-Prot:P96687" /translation="MSKMLYTLGGWVARNRIKAICAWIVVLVAAIGLAVTLKPSFSED MSIPDTPSEKAMDVIQKEFPHGPDKGSIRVIFGAGDGEKLTGKPAKKAIEDTFKEISK DDSVDSIASPFVTGTIAKDGTVAYADIQYKSSADDIKDYSIKHLKDSLKMADDEGLQT ELSGDVPGAEMEIGGVSEIVGIILAFVVLAITFGSLLIAGLPILTALIGLGVSIGLVL IGTQVFDIASVSLSLAGMIGLAVGIDYALFIFTKHRQFLGEGIQKNESIARAVGTAGS AVVFAGLTVIVALCGLTVVNIPFMSAMGLTAGLSVLMAVLASITLVPAVLSIAGKRMI PKSNKKIEKQSTETNVWGRFVTKNPIMLSVCSILILIVISIPSMHLELGLPDAGMKAK DNPDRRAYDLLAEGFGEGFNGQLTIVADATNATENKAEAFADAVKEIKGLDHVASVTP AMPNKEGNFAIITVVPETGPNDVTTKDLVHDVRSLSDKNGVDLLVTGSTAVNIDISDR LNDAIPVFAVLIVGFAFVLLTIVFRSLLVPLVAVAGFMLTMTATLGICVFVLQDGNLI DFFKIPEKGPILAFLPILSIGILFGLAMDYQVFLVSRMREEYVKTNNPVQAIQAGLKH SGPVVTAAGLIMIFVFAGFIFAGEASIKANGLALSFGVLFDAFIVRMTLIPSVMKLMG NAAWYLPKWLDKIIPNVDIEGHQLTKEIQPEIDHEQKKQISV*" /label="ydfJ CDS" gene 528711..530885 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /label="ydfJ gene" upshifts 528721 /Source="Nicolas_upshifts" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 528723..528741 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(529787..529805) /Source="Nicolas_upshift_promotors" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(529787) /Source="Nicolas_upshifts" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(530889..531296) /Source="Nicolas_S_feature" /locus_tag="new_591895_592302_c" /HighExp="Paraq, H2O2, Oxctl, aero, LBGexp, dia15, GM 150, M/G, ferm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S187" promotor_-35 530906..530910 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 530920 /Source="Nicolas_upshifts" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 530923..530942 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(530934) /Source="Nicolas_upshifts" /id="D260" /incds=0 /nref=22 /ntot=134 /MaxReadThrough="-0.100210000000001" /MaxDrop="3.637" /score="4.29161871" /energy="-8.8" /TU="NA" /idTUdmin="U422" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(531297..532199) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7765103, 22248594, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7765103, 22248594, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase NP" /protein_id="NP_388425.1" /db_xref="EnsemblGenomes-Gn:BSU05440" /db_xref="EnsemblGenomes-Tr:CAB12351" /db_xref="GOA:P96688" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:2R11" /db_xref="SubtiList:BG11957" /db_xref="UniProtKB/Swiss-Prot:P96688" /translation="MSNHSSSIPELSDNGIRYYQTYNESLSLWPVRCKSFYISTRFGQ THVIASGPEDAPPLVLLHGALFSSTMWYPNIADWSSKYRTYAVDIIGDKNKSIPENVS GTRTDYANWLLDVFDNLGIEKSHMIGLSLGGLHTMNFLLRMPERVKSAAILSPAETFL PFHHDFYKYALGLTASNGVETFLNWMMNDQNVLHPIFVKQFKAGVMWQDGSRNPNPNA DGFPYVFTDEELRSARVPILLLLGEHEVIYDPHSALHRASSFVPDIEAEVIKNAGHVL SMEQPTYVNERVMRFFNAETGISR*" /label="cesA CDS" gene complement(531297..532199) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /label="cesA gene" S_feature complement(532200..532295) /Source="Nicolas_S_feature" /locus_tag="new_593206_593301_c" /HighExp="nit, ferm, aero, LoTm, M/G, GM 150, Diami, Paraq, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S188" promotor_-10 complement(532275..532294) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(532295) /Source="Nicolas_upshifts" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(532308..532315) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(532401..533090) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10200972, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388426.1" /db_xref="EnsemblGenomes-Gn:BSU05450" /db_xref="EnsemblGenomes-Tr:CAB12352" /db_xref="GOA:P96689" /db_xref="InterPro:IPR007563" /db_xref="SubtiList:BG12158" /db_xref="UniProtKB/Swiss-Prot:P96689" /translation="MFGTIFNTVMIIAGSIIGGIFKKGIKDEYQDILMQAMGFAAVAL GINAITQHLPDSKYPILFIVSLAIGGLLGQIINLELRFNKLVNKFSKSNLAEGLSTAV LLFCIGSLSILGPVEAALHGDYTYLLTNGMLDGITSIVLASTFGFGIAAAALVLFSWQ GSIYLFAQVMESAINTDLINEITIVGGILILSSGLSILGIKKFKTLNLLPSLLIPPVV IFVIHAFGLRF*" /label="ydfK CDS" gene complement(532401..533090) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /label="ydfK gene" CDS complement(533180..533992) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of efflux transporter" /protein_id="NP_388427.1" /db_xref="EnsemblGenomes-Gn:BSU05460" /db_xref="EnsemblGenomes-Tr:CAB12353" /db_xref="GOA:P96690" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12159" /db_xref="UniProtKB/Swiss-Prot:P96690" /translation="MKEFFSIGEVSKLFNVKISALRYYDEIGLLKPEYKDEQTNYRYY STQQFERLDTIKYLRALGLPINKLLDFYNSQNTNTLLHLLKSQQVEIDRKKKELERIE RKISRRITHIEDAVNMPLHQISKIKLPAMRVAYLQHEYVLGHDIEHSLAELRTHLNVN EDIFIGKIGLSISAANVKAKQFDKYSSIFMILEDENEKTSSEIIFPSREYLQIRFKGS HPEAEPYYKKLLAYMKEHHYEVAGDSIEITLIDYGITNNLDNYVTEILLPIK*" /label="ydfL CDS" gene complement(533180..533992) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /label="ydfL gene" promotor_-10 complement(534021..534040) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(534034) /Source="Nicolas_upshifts" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(534056..534063) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(534103..534996) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="primary Mn(II) efflux pump" /protein_id="NP_388428.2" /db_xref="EnsemblGenomes-Gn:BSU05470" /db_xref="EnsemblGenomes-Tr:CAB12354" /db_xref="GOA:C0SP78" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12160" /db_xref="UniProtKB/Swiss-Prot:C0SP78" /translation="MASEREQISRKVALIALIANLILMAGKVFFGLVGDSEAVFADGI HSAADVVASIAVLAVIGISNKPPDQDHPFGHGKAEVISEAIVGIILVIVSVYILIEAI LSFVKGPSVPQYSALFAALISYVAKEILYRYSIKQGKKWNSKAIIAIAYDHKGDIVAS LAAFIGVLLAIIGNSRGWSYLLYADAIASAIVAYLIFKISMELIRPSVDVLMEKSVDP ELIEEYKAVIFQCDQVKRIDRIRAREHGHYKLLDVRLSLDHDLTIKQGHDIAREIRNE IKRQFSDVEEVLIHVNPYFEE*" /label="mneP CDS" gene complement(534103..534996) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /label="mneP gene" downshifts complement(534123) /Source="Nicolas_upshifts" /id="D261" /incds=0 /nref=23 /ntot=121 /MaxReadThrough="1.07979" /MaxDrop="4.0938" /score="12.079524" /energy="-6.2" /TU="NA" /idTUdmin="U424" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(534997..535089) /Source="Nicolas_S_feature" /locus_tag="new_596003_596095_c" /HighExp="LPh, HPh, LPhT, UNK1, MG t5, MG 5, MG 15, BMM, GM 120, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S189" promotor_-10 complement(535070..535089) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(535087) /Source="Nicolas_upshifts" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(535105..535112) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 535278..535285 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 535300..535319 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 535306 /Source="Nicolas_upshifts" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 535472..536092 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388429.1" /db_xref="EnsemblGenomes-Gn:BSU05480" /db_xref="EnsemblGenomes-Tr:CAB12355" /db_xref="GOA:P96692" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="PDB:3BEM" /db_xref="SubtiList:BG12161" /db_xref="UniProtKB/Swiss-Prot:P96692" /translation="MAEFTHLVNERRSASNFLSGHPITKEDLNEMFELVALAPSAFNL QHTKYVTVLDQDVKEKLKQAANGQYKVVSSSAVLLVLGDKQAYQQAADIYEGLKVLGI LNKQEYDHMVQDTVSFYENRGEQFKRDEAIRNASLSAMMFMLSAKEKGWDTCPMIGFD AEAVKRILNIDDQFEVVMMITIGKEKTESRRPRGYRKPVNEFVEYM*" /label="ydfN CDS" gene 535472..536092 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /label="ydfN gene" promotor_-35 535816..535822 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 535827 /Source="Nicolas_upshifts" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 535836..535854 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 536108..537046 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /EC_number="1.13.11.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dioxygenase" /protein_id="NP_388430.1" /db_xref="EnsemblGenomes-Gn:BSU05490" /db_xref="EnsemblGenomes-Tr:CAB12356" /db_xref="GOA:P96693" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:3OAJ" /db_xref="SubtiList:BG12162" /db_xref="UniProtKB/Swiss-Prot:P96693" /translation="MAKKTMGIHHITAIVGHPQENTDFYAGVLGLRLVKQTVNFDDPG TYHLYFGNEGGKPGTIITFFPWAGARQGVIGDGQVGVTSYVVPKGAMAFWEKRLEKFN VPYTKIERFGEQYVEFDDPHGLHLEIVEREEGEANTWTFGEVTPDVAIKGFGGATLLS EQPDKTADLLENIMGLERVGKEGDFVRYRSAGDIGNVIDLKLTPIGRGQMGAGTVHHI AWRANDDEDQLDWQRYIASHGYGVTPVRDRNYFNAIYFREHGEILFEIATDPPGFAHD ETQETMGEKLMLPVQYEPHRTQIEQGLLPFEVRELD*" /label="ydfO CDS" gene 536108..537046 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /label="ydfO gene" promotor_-35 537034..537037 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 537052..537071 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 537059..537147 /Source="Nicolas_S_feature" /locus_tag="new_598065_598153" /HighExp="Etha, BT, S6, S7, S8, G/S, GM 10, Gly, GM 15, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB, SigA" /TUshortPSig="0.658, 0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S190" upshifts 537059 /Source="Nicolas_upshifts" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 537148..537537 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15306018, 15849754, 16850406, 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound oxidoreductase" /protein_id="NP_388431.1" /db_xref="EnsemblGenomes-Gn:BSU05500" /db_xref="EnsemblGenomes-Tr:CAB12357" /db_xref="GOA:P96694" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12163" /db_xref="UniProtKB/Swiss-Prot:P96694" /translation="MEDAGLLLIRIMIGVVFLFYGTQKLFGWFGGYGIKGTGQWFESI GVKPGNVAAALSGLGELVSGILFILGVFLPLGAAIITIIMLGAIVKVHGAKGFANGAG GFEYNLVLIAVSIGVALIGSGAYALHF*" /label="ydfP CDS" gene 537148..537537 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /label="ydfP gene" downshifts 537528 /Source="Nicolas_upshifts" /id="D262" /incds=0 /nref=3 /ntot=91 /MaxReadThrough="1.0642" /MaxDrop="3.85597" /score="-8.69038499" /energy="-9.3" /TU="NA" /idTUdmin="U427" /TUdmin=29 /isTUend="FALSE" /label="downshifts" misc_feature 537651..537670 /Source="Nicolas_upshift_promotors" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 537653..537722 /Source="Nicolas_S_feature" /locus_tag="new_598659_598728" /HighExp="Diami, dia5, H2O2, dia15, Etha, S8, Paraq, Salt, LPhT, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S191" upshifts 537653 /Source="Nicolas_upshifts" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 537723..538061 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388432.1" /db_xref="EnsemblGenomes-Gn:BSU05510" /db_xref="EnsemblGenomes-Tr:CAB12358" /db_xref="GOA:P96695" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12164" /db_xref="UniProtKB/Swiss-Prot:P96695" /translation="MKEMTGLHSLVSIENFIKQHKFSFIYISRPGCTVCHAVLPQLRI VLDQFPNIKLGHINADDVAEVAGRFSVFTVPVLLLFIDGTEFLREARFVHFEQLEQKL KRVYRLYEGE*" /label="ydfQ CDS" gene 537723..538061 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /label="ydfQ gene" downshifts 538049 /Source="Nicolas_upshifts" /id="D263" /incds=0 /nref=9 /ntot=28 /MaxReadThrough="1.76745" /MaxDrop="4.78737" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(538101..538337) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="NP_388433.1" /db_xref="EnsemblGenomes-Gn:BSU05520" /db_xref="EnsemblGenomes-Tr:CAB12359" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12810" /db_xref="UniProtKB/Swiss-Prot:O31496" /translation="MRSQINISNLTINGMTQNANTDIGQNLQNSHTANSKNYGVNFTL GDYSPSHSIIISASCDNDTSDQGQVDNPSSPSEE*" /label="ydzH CDS" gene complement(538101..538337) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /label="ydzH gene" downshifts complement(538125) /Source="Nicolas_upshifts" /id="D264" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.87679" /MaxDrop="2.5881" /score="9.38580075" /energy="-6" /TU="NA" /idTUdmin="U430" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 538149..538155 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 538170..538181 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 538181 /Source="Nicolas_upshifts" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(538338..538499) /Source="Nicolas_S_feature" /locus_tag="new_599344_599505_c" /HighExp="BT, B36, S8, S7, G135, S5, S6, G180, Pyr, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S192" S_feature complement(538503..538868) /Source="Nicolas_S_feature" /locus_tag="new_599509_599874_c" /HighExp="BT, B36, S8, S7, S6, G/S, S5, Pyr, B60, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigGF, SigK" /TUshortPSig="0.994, 0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S193" downshifts complement(538543) /Source="Nicolas_upshifts" /id="D265" /incds=0 /nref=26 /ntot=52 /MaxReadThrough="2.64253" /MaxDrop="4.6761" /score="8.29803249" /energy="-12.4" /TU="NA" /idTUdmin="U430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(538869..539099) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="YP_003097687.1" /db_xref="EnsemblGenomes-Gn:BSU05529" /db_xref="EnsemblGenomes-Tr:CAX52560" /db_xref="InterPro:IPR019618" /db_xref="UniProtKB/Swiss-Prot:C0H3W2" /translation="MMKFPVYIHSISGNSVFNNGFAVSISPFSVSKTTEGSGGSNTGL VFESNALSQTSSANQAQNVTYAIQELLSKLLA*" /label="ydzR CDS" gene complement(538869..539099) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /label="ydzR gene" downshifts 539083 /Source="Nicolas_upshifts" /id="D266" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.08051" /MaxDrop="3.36374" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(539120..539139) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(539137) /Source="Nicolas_upshifts" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(539139..539222) /Source="Nicolas_S_feature" /locus_tag="new_600145_600228_c" /HighExp="S8, S5, S7, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK" /TUshortPSig="0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S194" promotor_-35 complement(539153..539162) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(539223..539900) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_388434.1" /db_xref="EnsemblGenomes-Gn:BSU05530" /db_xref="EnsemblGenomes-Tr:CAB12360" /db_xref="GOA:P96696" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12165" /db_xref="UniProtKB/Swiss-Prot:P96696" /translation="MNRLPFGYIKLRLAGRKANPMTNLIHHWSGGSMNFTWESLVLIV AGVILLRISGRKSIAQMTSTQTVVMISIGTIIVQPIIEYSLFKTLIAAAIFTSTLIVM EWIQMKSNTIEKMLTGKAKIVIENGQLHIENLKKMRLTADQLEMQLRLHGVTAIQDVK IATLEANGQLGIELTDDAKPLTVRDLKKLIHPDFINKDGQAQSGNQNIFDEVGKKNKK NVPKKLH*" /label="ydfR CDS" gene complement(539223..539900) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /label="ydfR gene" promotor_-10 complement(539871..539882) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(539885) /Source="Nicolas_upshifts" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(539897..539903) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(539901..540734) /Source="Nicolas_S_feature" /locus_tag="new_600907_601740_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, nit, B60" /AntisenseName="ydfS" /AntisenseCor="0.65823831974361602" /AntisenseRegPval="-34.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S195" promotor_-35 539916..539921 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 539936..539947 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 539941 /Source="Nicolas_upshifts" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="upshifts" CDS 540013..540720 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388435.1" /db_xref="EnsemblGenomes-Gn:BSU05540" /db_xref="EnsemblGenomes-Tr:CAB12361" /db_xref="GOA:P96697" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12166" /db_xref="UniProtKB/Swiss-Prot:P96697" /translation="MIELEVVIRTVASFGLLLIAERILGKQTISQMTIFDFIAAITLG AIAAGLAYNTSIKPHNMAISFSIFVLTIFLISFLSIKNRKLRKFFAGDPTVLIQNGKI LESNMRKMRYTLDYLNQQLREKEIFNIEEVLFAILETNGQLTVLRKPQFRHVTKQDLM IAVNQEQRLPIELIMDGEIIENNLKQNRLTESWLLEELRKRDIKVKETVYAVLLGNGD IYVDQYKDHISVPMDKE*" /label="ydfS CDS" gene 540013..540720 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /label="ydfS gene" CDS complement(540735..541166) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11150673; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_388436.1" /db_xref="EnsemblGenomes-Gn:BSU05550" /db_xref="EnsemblGenomes-Tr:CAB12362" /db_xref="GOA:P96698" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG12167" /db_xref="UniProtKB/Swiss-Prot:P96698" /translation="MDFEKIRKWLEITNEYKQSDFWTNVLKYKAPEHFFDSEASTFVY DFYQDEEYNFIIVEMPGVYEEELTIRLLSKTQLLIKGTITPVFPAEMEVLRERYYGEI ERIIQLPEAAETHLLQIQLLNGLLHISYPRQVETVAFNKGL*" /label="cotP CDS" gene complement(540735..541166) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /label="cotP gene" CDS complement(541179..541421) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388437.1" /db_xref="EnsemblGenomes-Gn:BSU05560" /db_xref="EnsemblGenomes-Tr:CAB12363" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12168" /db_xref="UniProtKB/Swiss-Prot:P96699" /translation="MPYQINIANIKINGVTQNGNIDVGPTVHNSHTANSKYFGANFSL GDLSPTSSLLNTGNIDSDVSDQDQIGNPSAPISNQI*" /label="ydgA CDS" gene complement(541179..541421) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /label="ydgA gene" CDS complement(541435..541707) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388438.1" /db_xref="EnsemblGenomes-Gn:BSU05570" /db_xref="EnsemblGenomes-Tr:CAB12364" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12169" /db_xref="UniProtKB/Swiss-Prot:P96700" /translation="MPSTVINLYYLKINSISGNGSITIGEAAYNSPTNNQKSQGTNSS FGDTSPTESVMENFLNDPDVNDQTSIGNSDTSNVNAPPIAPPPILD*" /label="ydgB CDS" gene complement(541435..541707) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /label="ydgB gene" promotor_-10 complement(541729..541748) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(541733) /Source="Nicolas_upshifts" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(541762..541771) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 541926..541933 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 541949..541968 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 541957 /Source="Nicolas_upshifts" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="upshifts" CDS 542006..542593 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388439.1" /db_xref="EnsemblGenomes-Gn:BSU05580" /db_xref="EnsemblGenomes-Tr:CAB12365" /db_xref="GOA:P96701" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12170" /db_xref="UniProtKB/Swiss-Prot:P96701" /translation="MKSKGVESRKRLLKAAANEFSVRGFHDAKVSEIVKKAGFTQPSF YLYFQSKEAIFAELITDFHSRVRKLTESLLLENGLNTEDVSKRVLLAVETVFQFLDED KDLTKIGFFLNPEAKQMKKDLAMVLKENLEAEQRLGYFHSELDMETVAECLVGMIEHL TESFLLTGIKDPASLAAEVVNLLIYGMLPKGNDVR*" /label="ydgC CDS" gene 542006..542593 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /label="ydgC gene" CDS 542590..542934 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388440.1" /db_xref="EnsemblGenomes-Gn:BSU05590" /db_xref="EnsemblGenomes-Tr:CAB12366" /db_xref="GOA:P96702" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12171" /db_xref="UniProtKB/Swiss-Prot:P96702" /translation="MISIMMKVSLAVFMLAGGIIKVSRVPFQVEHWRHYQYPLWFLTV TGILEIAGALAMTAGIWNRYAAIGAGVLFVVLMAGAIHAHMFRARQSVIMAIQAMICL IVSIMIIMGSYT*" /label="ydgD CDS" gene 542590..542934 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /label="ydgD gene" S_feature 542935..543096 /Source="Nicolas_S_feature" /locus_tag="new_603941_604102" /HighExp="Salt, Diami, dia15, dia5, aero, H2O2, SMMPr, Etha, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S196" CDS 543097..543570 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388441.1" /db_xref="EnsemblGenomes-Gn:BSU05600" /db_xref="EnsemblGenomes-Tr:CAB12367" /db_xref="GOA:P96703" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12172" /db_xref="UniProtKB/Swiss-Prot:P96703" /translation="MAFTLEDMTEEEFEAFRGMSVQNFAKQNITSGTWTEKEAFEKSE QAYENMIPNGRDSSNHYFWNITNDQGERMGWLWLYADPLHPQKEAFIYSFGLYEAFRG KGLAQLALQTLDERARELGAERLALHVFAHNETAVYLYQKMGYAMTNIRMRKQLC*" /label="ydgE CDS" gene 543097..543570 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /label="ydgE gene" S_feature 543571..544263 /Source="Nicolas_S_feature" /locus_tag="new_604577_605269" /HighExp="Salt, H2O2, dia15, aero, T-2.40H, Diami, T-3.40H, T-1.40H, T-4.40H, T-0.40H" /AntisenseName="vmlR" /AntisenseCor="-7.1224465259194999E-2" /AntisenseRegPval="-0.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S197" downshifts complement(543713) /Source="Nicolas_upshifts" /id="D267" /incds=0 /nref=4 /ntot=88 /MaxReadThrough="0.39199" /MaxDrop="3.39645" /score="18.2783449" /energy="-8.8" /TU="NA" /idTUdmin="U436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(543730..545373) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16109936, 22226636, 24687494, 25891423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16109936, 22226636, 24687494, 25891423; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding cassette efflux transporter" /protein_id="NP_388442.1" /db_xref="EnsemblGenomes-Gn:BSU05610" /db_xref="EnsemblGenomes-Tr:CAB12368" /db_xref="GOA:P39115" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG10767" /db_xref="UniProtKB/Swiss-Prot:P39115" /translation="MKEIVTLTNVSYEVKDQTVFKHVNASVQQGDIIGIIGKNGAGKS TLLHLIHNDLAPAQGQILRKDIKLALVEQETAAYSFADQTPAEKKLLEKWHVPLRDFH QLSGGEKLKARLAKGLSEDADLLLLDEPTNHLDEKSLQFLIQQLKHYNGTVILVSHDR YFLDEAATKIWSLEDQTLIEFKGNYSGYMKFREKKRLTQQREYEKQQKMVERIEAQMN GLASWSEKAHAQSTKKEGFKEYHRVKAKRTDAQIKSKQKRLEKELEKAKAEPVTPEYT VRFSIDTTHKTGKRFLEVQNVTKAFGERTLFKNANFTIQHGEKVAIIGPNGSGKTTLL NIILGQETAEGSVWVSPSANIGYLTQEVFDLPLEQTPEELFENETFKARGHVQNLMRH LGFTAAQWTEPIKHMSMGERVKIKLMAYILEEKDVLILDEPTNHLDLPSREQLEETLS QYSGTLLAVSHDRYFLEKTTNSKLVISNNGIEKQLNDVPSERNEREELRLKLETERQE VLGKLSFMTPNDKGYKELDQAFNELTKRIKELDHQDKKD*" /label="vmlR CDS" gene complement(543730..545373) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /label="vmlR gene" S_feature complement(545408..545605) /Source="Nicolas_S_feature" /locus_tag="new_606414_606611_c" /HighExp="BC, Sw, B60, B36, LoTm, S7, HiOs, S4, BI, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S198" promotor_-35 545422..545424 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 545441..545459 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 545445 /Source="Nicolas_upshifts" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(545451) /Source="Nicolas_upshifts" /id="D268" /incds=0 /nref=210 /ntot=265 /MaxReadThrough="3.59768" /MaxDrop="6.27457" /score="29.5863709" /energy="-11.8" /TU="U436" /idTUdmin="U437" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 545571 /Source="Nicolas_upshifts" /id="D269" /incds=0 /nref=35 /ntot=150 /MaxReadThrough="1.71902" /MaxDrop="4.95368" /score="-7.23582918" /energy="-13.3" /TU="NA" /idTUdmin="U435" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(545597..545616) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(545609) /Source="Nicolas_upshifts" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(545629..545636) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(545692) /Source="Nicolas_upshifts" /id="D270" /incds=0 /nref=92 /ntot=203 /MaxReadThrough="2.22553" /MaxDrop="5.71399" /score="18.9878298" /energy="-13.3" /TU="NA" /idTUdmin="U437" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(545693..547069) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16109936, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388443.1" /db_xref="EnsemblGenomes-Gn:BSU05620" /db_xref="EnsemblGenomes-Tr:CAB12369" /db_xref="GOA:P96704" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12173" /db_xref="UniProtKB/Swiss-Prot:P96704" /translation="MTDDMTKDNINQQTLQRGLKNRHIQLIAIGGAIGTGLFLGSGKS IHFAGPSILFAYMITGIICFLIMRSLGELLLSNLNYHSFVDFVQDYLGDMAAFITGWT YWFCWISIAMADLTAVGLYTQYWLPGVPQWVPGLIALIILLIMNLATVKLFGELEFWF ALIKVIAILALIVIGLVMIFKGFSTSSGVSSFTNLWSHGGLFPNGMHGFILSFQMVVF AFVGIELVGLTAGETENPEKVIPKAINNIPVRVLLFYIGALLVIMSIYPWDIINPSES PFVQVFVAVGIVGAASIINFVVLTSAASACNSAVFSTSRMVYSLAKDHNAPESMAKLT QRKVPRNALFFSAIVILIGVTLNYIMPEGVFTLITSISTVCFIYIWGITVICHMKYRK TRPELAKTNKFKLPLYPFTNYLILAFLAFVLVVLALAQDTRVSLFVTPVWFILLIVIY KVRKAKHQ*" /label="ydgF CDS" gene complement(545693..547069) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /label="ydgF gene" misc_feature complement(547119..547138) /Source="Nicolas_upshift_promotors" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(547134) /Source="Nicolas_upshifts" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="upshifts" Polymorphism join(547208,547210) /Source="geneious" /ID="SNP_BsDelta6_608215_608214" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)5 -> (A)6" /Codon_Change /Coverage=41 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="8.2e-115" /Variant_Raw_Frequency=39 /comment="dinB_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" terminator 547209..547242 /created_by="User" /comment="dinB_terminator_improvement" /modified_by="User" /label="Delta6_dinB_Terminator" CDS complement(547241..547759) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1847907, 3110138, 12644484, 16267290, 22059487; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nuclease inhibitor" /protein_id="NP_388444.1" /db_xref="EnsemblGenomes-Gn:BSU05630" /db_xref="EnsemblGenomes-Tr:CAB12370" /db_xref="GOA:Q02886" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG10539" /db_xref="UniProtKB/Swiss-Prot:Q02886" /translation="MSDFAFKLYEYNVWANQQIFNRLKELPKEIYHQEIQSVFPSISH VLSHVYLSDLGWIEVFSGKTLSDALALAEQLKEQTEAKEIEEMEDLFLRLSERYILFL QQKEQLNKPLQIQNPSSGIMKTTVSELLPHVVNHGTYHRGNITAMLRQAGYASAPTDY GLYLFMTKTEKA*" /label="dinB CDS" gene complement(547241..547759) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /label="dinB gene" downshifts complement(547255) /Source="Nicolas_upshifts" /id="D271" /incds=0 /nref=35 /ntot=176 /MaxReadThrough="2.77148" /MaxDrop="6.32316" /score="16.2748201" /energy="-15" /TU="NA" /idTUdmin="U438" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(547785..547804) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(547804) /Source="Nicolas_upshifts" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(547820..547823) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 547841..547848 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 547863..547882 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 547881 /Source="Nicolas_upshifts" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="upshifts" CDS complement(547893..548294) /gene="ydhUc" /locus_tag="PG10_BSU_05890_3'_ext" /locus_tag="BSU_05890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; C-terminal part of YhdU" /db_xref="SubtiList:BG12198" /modified_by="User" /translation="FFQSSNFRGKQKQYRDLLRGIFLEEIAHVELVQNTINALLDESG GEGVGSQGTDQAPLDEAVKHANPHHYIIGAQSSLPVDAGGNPWNGSWVYNHGNLITDL LDNLLLESTGVLQKTRIYEMSSNQTHYSLPR*" /label="PG10_BSU_05890_3'_ext" CDS complement(547893..548021) /locus_tag="PG10_rand_002" /created_by="User" /transl_table=11 /pseudo /translation="MYNHGNLITDLLDNLLLESTGVLQKTRIYEMSSNQTHYSLPR*" /label="PG10_rand_002" gene complement(547893..548294) /gene="ydhUc" /locus_tag="PG10_BSU_05890_3'_ext" /old_locus_tag="BSU_05890" /pseudo /modified_by="User" /label="PG10_BSU_05890_3'_ext" gene complement(547893..548021) /locus_tag="PG10_rand_002" /created_by="User" /label="PG10_rand_002" CDS 547911..548003 /locus_tag="PG10_rand_001" /created_by="User" /transl_table=11 /pseudo /translation="MRLIRAHFINSCFLQHTCRLKKQVIQQVSN*" /label="PG10_rand_001" gene 547911..548003 /locus_tag="PG10_rand_001" /created_by="User" /modified_by="User" /label="PG10_rand_001" SCAR 547913..547914 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs22" CDS complement(548225..548419) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; N-terminal part of YhdU" /translation="MYYYKEELINIIKPDKPDPAAAKVLQEILGGHYGEMRTMMQFFS KALISEESRNSTAICFAAFF*" /label="ydhUn CDS" gene complement(548225..548419) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /pseudo /label="ydhUn gene" promotor_-10 complement(548452..548463) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(548460) /Source="Nicolas_upshifts" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(548477..548483) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 548538..548545 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 548559..548578 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box 548561..548661 /Source="Nicolas_upshift_promotors" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 548563 /Source="Nicolas_upshifts" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(548609) /Source="Nicolas_upshifts" /id="D286" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="2.24619" /MaxDrop="4.20389" /score="11.9939391" /energy="-9" /TU="NA" /idTUdmin="U456" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" upshifts 548621 /Source="Nicolas_upshifts" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 548629..548636 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 548650..548669 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 548665..548752 /Source="Nicolas_S_feature" /locus_tag="new_635022_635109" /HighExp="LBGstat, C30, Cold, Heat, Oxctl, T-1.10H, T-0.40H, T-1.40H, UNK1, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.96, 0.0919, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S204" upshifts 548665 /Source="Nicolas_upshifts" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" tRNA 548753..548829 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Arg tRNA" gene 548753..548829 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /label="trnE-Arg gene" tRNA 548843..548916 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(UCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Gly tRNA" gene 548843..548916 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /label="trnE-Gly gene" rRNA 549076..550630 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-16S rRNA" gene 549076..550630 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /label="rrnE-16S gene" rRNA 550798..553725 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-23S rRNA" gene 550798..553725 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /label="rrnE-23S gene" rRNA 553781..553897 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-5S rRNA" gene 553781..553897 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /label="rrnE-5S gene" tRNA 553911..553987 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Met tRNA" gene 553911..553987 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /label="trnE-Met gene" tRNA 554048..554124 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Asp tRNA" gene 554048..554124 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /label="trnE-Asp gene" downshifts 554121 /Source="Nicolas_upshifts" /id="D287" /incds=0 /nref=38 /ntot=211 /MaxReadThrough="6.00554" /MaxDrop="5.14761" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U460" /TUdmin="-3784" /isTUend="FALSE" /label="downshifts" promotor_-35 554225..554229 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 554245..554264 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 554249 /Source="Nicolas_upshifts" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="upshifts" CDS 554305..555282 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /EC_number="2.7.4.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-monophosphate kinase" /protein_id="NP_388471.1" /db_xref="EnsemblGenomes-Gn:BSU05900" /db_xref="EnsemblGenomes-Tr:CAB12409" /db_xref="GOA:O05514" /db_xref="InterPro:IPR006283" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10693" /db_xref="UniProtKB/Swiss-Prot:O05514" /translation="MDEFDLIHSITPRTIHHSSVDVGIGDDAALYTAKHGVQEIVCVD TMVEDVHFKLHYSSPEDIGYKALAVNISDIAAMGGIPKFYLVSLAVPSKWTESEIKAM YEGMNELAKLYHMDLIGGDTVSTADKLVVTVTVIGEIEKGQACLRSLAKPNDIVFVTG EIGSSAAGLSLLLEETNPQNSSVETDYFIHRHKRPEPRVSVGRLCSIFKRAALNDVSD GLASELNEIAEASCVSIEIVESMLPIHSDLPKLHPNWKEWALFGGEDFELTGTVSNEE WEVLKQECAALHLPITKIGYVREKTKSKVILKTDQTSMILEKKGYNHFK*" /label="thiL CDS" gene 554305..555282 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /label="thiL gene" CDS 555297..555773 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; ADP binding protein" /protein_id="NP_388472.1" /db_xref="EnsemblGenomes-Gn:BSU05910" /db_xref="EnsemblGenomes-Tr:CAB12410" /db_xref="GOA:O05515" /db_xref="InterPro:IPR003442" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12199" /db_xref="UniProtKB/Swiss-Prot:O05515" /translation="MKQLKWRTVNPEETKAIAKLTAAFAKPGDVLTLEGDLGAGKTTF TKGFAEGLGITRIVNSPTFTIIKEYNDGVLPLYHMDVYRMEDESEDLGLDEYFHGQGV CLVEWAHLIEEQLPQERLQIVIKRAGDDEREITFTAVGNRYEMLCEELSRHDNISN*" /label="tsaE CDS" gene 555297..555773 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /label="tsaE gene" CDS 555754..556443 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; protease involved in TsaD function" /protein_id="NP_388473.1" /db_xref="EnsemblGenomes-Gn:BSU05920" /db_xref="EnsemblGenomes-Tr:CAB12411" /db_xref="GOA:O05516" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR022496" /db_xref="SubtiList:BG12200" /db_xref="UniProtKB/Swiss-Prot:O05516" /translation="MTILAIDTSNYTLGIALLREDTVIAEYITYLKKNHSVRAMPAVH SLLNDCDMAPQDLSKIVVAKGPGSYTGVRIGVTLAKTLAWSLDIPISAVSSLETLAAN GRHFDGLISPIFDARRGQVYTGLYQYKNGLLEQVVPDQNVMLADWLEMLKEKDRPVLF LGHDTSLHKQMIEDVLGTKGFIGTAAQHNPRPSELAFLGKEKEAADVHGLVPDYLRLA EAEAKWIESQK*" /label="tsaB CDS" gene 555754..556443 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /label="tsaB gene" CDS 556453..556908 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /EC_number="2.3.1.267" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2828880; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein S18 alanine N-acetyltransferase" /protein_id="NP_388474.1" /db_xref="EnsemblGenomes-Gn:BSU05930" /db_xref="EnsemblGenomes-Tr:CAB12412" /db_xref="GOA:O05517" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR006464" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12201" /db_xref="UniProtKB/Swiss-Prot:O05517" /translation="MKTKAAVRNMRLEDIDHVYEIEASSFTSPWTKDSFYHELLENPY AHYLVIEKDGHLAGYCGIWIVMDDAQITNIAIKPEYRGQSLGETLFRSAVELCKEKDA RRLSLEVRVSNHPAQGLYKKFGMQPGGIRKNYYTDNGEDALIMWVTINE*" /label="rimI CDS" gene 556453..556908 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /label="rimI gene" CDS 556901..557941 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11073929, 12682299, 9743119, 20824107, 21625506, 21873492, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; glycation binding protein" /protein_id="NP_388475.1" /db_xref="EnsemblGenomes-Gn:BSU05940" /db_xref="EnsemblGenomes-Tr:CAB12413" /db_xref="GOA:O05518" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR017860" /db_xref="InterPro:IPR017861" /db_xref="InterPro:IPR022450" /db_xref="SubtiList:BG12202" /db_xref="UniProtKB/Swiss-Prot:O05518" /translation="MSEQKDMYVLGIETSCDETAAAIVKNGKEIISNVVASQIESHKR FGGVVPEIASRHHVEQITLVIEEAFRKAGMTYSDIDAIAVTEGPGLVGALLIGVNAAK ALSFAYNIPLVGVHHIAGHIYANRLVEDIVFPALALVVSGGHTELVYMKEHGSFEVIG ETLDDAAGEAYDKVARTMGLPYPGGPQIDKLAEKGNDNIPLPRAWLEEGSYNFSFSGL KSAVINTLHNASQKGQEIAPEDLSASFQNSVIDVLVTKTARAAKEYDVKQVLLAGGVA ANRGLRAALEKEFAQHEGITLVIPPLALCTDNAAMIAAAGTIAFEKGIRGAYDMNGQP GLELTSYQSLTR*" /label="tsaD CDS" gene 556901..557941 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /label="tsaD gene" downshifts 557905 /Source="Nicolas_upshifts" /id="D288" /incds=0 /nref=39 /ntot=222 /MaxReadThrough="3.15518" /MaxDrop="4.65228" /score="3.97936019" /energy="-10.1" /TU="NA" /idTUdmin="U460" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(558171..560099) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11916677, 16109936, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388476.2" /db_xref="EnsemblGenomes-Gn:BSU05950" /db_xref="EnsemblGenomes-Tr:CAB12414" /db_xref="GOA:O05519" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12203" /db_xref="UniProtKB/Swiss-Prot:O05519" /translation="MMILQVNQLSKSFGADTILNNIKLEVRNRDRIAIVGRNGAGKST LLKIIAGQLSYEKGEIIKPKDITMGYLAQHTGLDSKLTIKEELLTVFDHLKAMEKEMR AMEEKMAAADPGELESIMKTYDRLQQEFKDKGGYQYEADVRSVLHGLGFSHFDDSTQV QSLSGGQKTRLALGKLLLTQPDLLILDEPTNHLDIDTLTWLEHYLQGYSGAILIVSHD RYFLDKVVNQVYEVSRAESKKYHGNYSAYLDQKAAQYEKDLKMYEKQQDEIAKLQDFV DRNLARASTTKRAQSRRKQLERMDVMSKPLGDEKSANFHFDITKQSGNEVLRVQDLTI SYENQPPLLTEVSFMLTRGESAALVGPNGIGKSTLLKTLIDTLKPDQGTISYGSNVSV GYYDQEQAELTSSKRVLDELWDEYPGLPEKEIRTCLGNFLFSGDDVLKPVHSLSGGEK ARLALAKLMLQKANFLILDEPTNHLDLDSKEVLENALIDYPGTLLFVSHDRYFINRIA TRVLELSSSHIEEYLGDYDYYTEKKTEQLELEKMNQQEETDKTPATVKSDSKRSYEEE KEWKKKERQRLRRIEEIETTVQTIEENISRNDELLCDPEVYQDHEKVQAIHADNEKLN QELESLLSEWEELSTEED*" /label="ydiF CDS" gene complement(558171..560099) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /label="ydiF gene" downshifts complement(558188) /Source="Nicolas_upshifts" /id="D289" /incds=0 /nref=170 /ntot=266 /MaxReadThrough="1.32926" /MaxDrop="5.81869" /score="16.702581" /energy="-12.6" /TU="NA" /idTUdmin="U463" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" misc_feature 559851..559870 /Source="Nicolas_upshift_promotors" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 559861 /Source="Nicolas_upshifts" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" S_feature 559863..560052 /Source="Nicolas_S_feature" /locus_tag="new_646220_646409" /HighExp="Diami, H2O2, dia5, Paraq, G135, G180, G150, Cold, dia15, BC" /AntisenseName="ydiF" /AntisenseCor="0.47406689574609401" /AntisenseRegPval="-15.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S205" promotor_-35 560017..560024 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 560038..560057 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 560054..560224 /Source="Nicolas_S_feature" /locus_tag="new_646411_646581" /HighExp="Diami, dia5, dia15, H2O2, Etha, G180, G150, Oxctl, Mt0, Paraq" /AntisenseName="ydiF" /AntisenseCor="0.63697451027099605" /AntisenseRegPval="-31.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S206" upshifts 560054 /Source="Nicolas_upshifts" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(560119..560138) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(560131) /Source="Nicolas_upshifts" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(560152..560159) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 560225..560737 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /EC_number="4.6.1.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10903949, 16632608, 18607082, 20606263, 25941396, 26575208; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdenum cofactor biosynthesis protein C" /protein_id="NP_388477.1" /db_xref="EnsemblGenomes-Gn:BSU05960" /db_xref="EnsemblGenomes-Tr:CAB12415" /db_xref="GOA:O05520" /db_xref="InterPro:IPR002820" /db_xref="InterPro:IPR023045" /db_xref="InterPro:IPR036522" /db_xref="SubtiList:BG12204" /db_xref="UniProtKB/Swiss-Prot:O05520" /translation="MNGFSHFNEQGRAQMVDISEKSSTVRTAAAVSSVHMKNEVYEKI QSHDIGKGDVLAVAQVAGIMAAKQTSNIIPMCHPLSLSGVDISFDWKIKEAEVILHIK AQVKTKGSTGVEMEALTSASVCALTVYDMCKALDKGMVIGPTFLLEKTGGKNGDFKRE LSEYNLEDQK*" /label="moaC CDS" gene 560225..560737 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /label="moaC gene" CDS 560734..561381 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription repressor of cydABCD and yjlC-ndh expression" /protein_id="NP_388478.1" /db_xref="EnsemblGenomes-Gn:BSU05970" /db_xref="EnsemblGenomes-Tr:CAB12416" /db_xref="GOA:O05521" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR009718" /db_xref="InterPro:IPR022876" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2VT2" /db_xref="PDB:2VT3" /db_xref="SubtiList:BG12205" /db_xref="UniProtKB/Swiss-Prot:O05521" /translation="MNKDQSKIPQATAKRLPLYYRFLKNLHASGKQRVSSAELSDAVK VDSATIRRDFSYFGALGKKGYGYNVDYLLSFFRKTLDQDEMTDVILIGVGNLGTAFLH YNFTKNNNTKISMAFDINESKIGTEVGGVPVYNLDDLEQHVKDESVAILTVPAVAAQS ITDRLVALGIKGILNFTPARLNVPEHIRIHHIDLAVELQSLVYFLKHYSVLEEIE*" /label="rex CDS" gene 560734..561381 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /label="rex gene" promotor_no_box 561211..561311 /Source="Nicolas_upshift_promotors" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 561271 /Source="Nicolas_upshifts" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" CDS 561403..561576 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388479.1" /db_xref="EnsemblGenomes-Gn:BSU05980" /db_xref="EnsemblGenomes-Tr:CAB12417" /db_xref="GOA:O05522" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG12206" /db_xref="UniProtKB/Swiss-Prot:O05522" /translation="MPIGPGSLAVIAIVALIIFGPKKLPELGKAAGDTLREFKNATKG LTSDEEEKKKEDQ*" /label="tatAY CDS" gene 561403..561576 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /label="tatAY gene" CDS 561583..562347 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11007775, 15187182, 15849754, 16850406, 19049517, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007775, 15187182, 15849754, 16850406, 19049517, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388480.1" /db_xref="EnsemblGenomes-Gn:BSU05990" /db_xref="EnsemblGenomes-Tr:CAB12418" /db_xref="GOA:O05523" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG12207" /db_xref="UniProtKB/Swiss-Prot:O05523" /translation="MTRMKVNQMSLLEHIAELRKRLLIVALAFVVFFIAGFFLAKPII VYLQETDEAKQLTLNAFNLTDPLYVFMQFAFIIGIVLTSPVILYQLWAFVSPGLYEKE RKVTLSYIPVSILLFLAGLSFSYYILFPFVVDFMKRISQDLNVNQVIGINEYFHFLLQ LTIPFGLLFQMPVILMFLTRLGIVTPMFLAKIRKYAYFTLLVIAALITPPELLSHMMV TVPLLILYEISILISKAAYRKAQKSSAADRDVSSGQ*" /label="tatCY CDS" gene 561583..562347 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /label="tatCY gene" downshifts 562327 /Source="Nicolas_upshifts" /id="D290" /incds=0 /nref=151 /ntot=251 /MaxReadThrough="4.01237" /MaxDrop="6.80817" /score="19.4098216" /energy="-12.7" /TU="NA" /idTUdmin="U461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(562385..562576) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388481.1" /db_xref="EnsemblGenomes-Gn:BSU06000" /db_xref="EnsemblGenomes-Tr:CAB12419" /db_xref="GOA:O05524" /db_xref="InterPro:IPR025426" /db_xref="SubtiList:BG12208" /db_xref="UniProtKB/Swiss-Prot:O05524" /translation="MRNPVVWGMIYFAVGCIFTYLAASSPGSMWSFYSILLMVFAAYN ISISFKMFAFSFKIKKNQK*" /label="ydiK CDS" gene complement(562385..562576) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /label="ydiK gene" downshifts complement(562402) /Source="Nicolas_upshifts" /id="D291" /incds=0 /nref=211 /ntot=258 /MaxReadThrough="0.81338" /MaxDrop="6.43897" /score="25.5376889" /energy="-12.7" /TU="NA" /idTUdmin="U467" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(562573..563307) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /EC_number="3.4.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_388482.1" /db_xref="EnsemblGenomes-Gn:BSU06010" /db_xref="EnsemblGenomes-Tr:CAB12420" /db_xref="GOA:O05525" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG12209" /db_xref="UniProtKB/Swiss-Prot:O05525" /translation="MRKQYWFIILTYIIMQFSALIAIPLLFKFGYAGGQPTDENMLHA QGLWSVISFIACLVVVLLILRTVPKETLRNGQKDSIGLSILWAIAGFFIALFSQGIAG SIEYYVFGIGRESENTQAILDVIQAVPLMIIVSSIVGPILEEIIFRKIIFGALYEKTN FFFAGLISSVIFGIVHADLKHLLLYTAMGFTFAFLYARTKRIWVPIFAHLMMNTFVVI MQLEPVRNYLEQQSTQMQLIIGGLFL*" /label="ydiL CDS" gene complement(562573..563307) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /label="ydiL gene" promotor_-35 562965..562970 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 562985..563003 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 562987 /Source="Nicolas_upshifts" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 563306..563307 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-35" promotor_-10 563317..563331 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-10" upshifts 563339 /Source="Nicolas_upshifts" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="upshifts" promotor_-10 complement(563344..563363) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 563361..563469 /Source="Nicolas_S_feature" /locus_tag="new_649718_649826" /HighExp="S4, S5, H2O2, S3, S8, S6, Diami, Oxctl, G180, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.238" /TUlongSig="NA" /TUlongPSig="NA" /label="S207" upshifts complement(563364) /Source="Nicolas_upshifts" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(563377..563382) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 563443..563449 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 563463..563482 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 563471..563545 /Source="Nicolas_S_feature" /locus_tag="new_649828_649902" /HighExp="HiTm, Etha, dia15, Heat, C90, dia5, LoTm, Lbexp, H2O2, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S208" upshifts 563471 /Source="Nicolas_upshifts" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="upshifts" CDS 563546..563830 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11407116, 17031040, 9303302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11407116, 17031040, 9303302; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin small subunit" /protein_id="NP_388483.2" /db_xref="EnsemblGenomes-Gn:BSU06020" /db_xref="EnsemblGenomes-Tr:CAB12421" /db_xref="GOA:P28599" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR018369" /db_xref="InterPro:IPR020818" /db_xref="InterPro:IPR037124" /db_xref="SubtiList:BG10422" /db_xref="UniProtKB/Swiss-Prot:P28599" /translation="MLKPLGDRVVIELVESEEKTASGIVLPDSAKEKPQEGKIVAAGS GRVLESGERVALEVKEGDRIIFSKYAGTEVKYEGTEYLILRESDILAVIG*" /label="groES CDS" gene 563546..563830 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /label="groES gene" CDS 563877..565511 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9303302, 11407116, 17031040, 17420574, 22268681" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 11407116, 17031040, 17420574, 22268681; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin large subunit" /protein_id="NP_388484.1" /db_xref="EnsemblGenomes-Gn:BSU06030" /db_xref="EnsemblGenomes-Tr:CAB12422" /db_xref="GOA:P28598" /db_xref="InterPro:IPR001844" /db_xref="InterPro:IPR002423" /db_xref="InterPro:IPR018370" /db_xref="InterPro:IPR027409" /db_xref="InterPro:IPR027410" /db_xref="InterPro:IPR027413" /db_xref="SubtiList:BG10423" /db_xref="UniProtKB/Swiss-Prot:P28598" /translation="MAKEIKFSEEARRAMLRGVDALADAVKVTLGPKGRNVVLEKKFG SPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREG LKNVTAGANPVGVRKGMEQAVAVAIENLKEISKPIEGKESIAQVAAISAADEEVGSLI AEAMERVGNDGVITIEESKGFTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLDNPYI LITDKKITNIQEILPVLEQVVQQGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKA PGFGDRRKAMLEDIAVLTGGEVITEDLGLDLKSTQIAQLGRASKVVVTKENTTIVEGA GETDKISARVTQIRAQVEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKL RIEDALNSTRAAVEEGIVSGGGTALVNVYNKVAAVEAEGDAQTGINIVLRALEEPIRQ IAHNAGLEGSVIVERLKNEEIGVGFNAATGEWVNMIEKGIVDPTKVTRSALQNAASVA AMFLTTEAVVADKPEENGGGAGMPDMGGMGGMGGMM*" /label="groEL CDS" gene 563877..565511 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /label="groEL gene" S_feature 565512..565604 /Source="Nicolas_S_feature" /locus_tag="new_651869_651961" /HighExp="HiTm, Etha, dia15, Heat, Diami, dia5, C90, S1, S2, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S209" downshifts 565561 /Source="Nicolas_upshifts" /id="D292" /incds=0 /nref=228 /ntot=267 /MaxReadThrough="6.24882" /MaxDrop="5.77437" /score="-6.71161833" /energy="-16.3" /TU="U468" /idTUdmin="U466" /TUdmin=2112 /isTUend="FALSE" /label="downshifts" CDS complement(565599..565727) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); C-terminal part of YdzT; defective prophage 3" /translation="EAGVGIKEIQQQFGHSDINTTMDIYAHMTANMEKRSPNSLVN*" /label="ydzTc CDS" gene complement(565599..565727) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /pseudo /label="ydzTc gene" S_feature 565606..>566832 /Source="Nicolas_S_feature" /locus_tag="new_651963_653431" /HighExp="H2O2, Heat, dia15, Diami, S1, G135, G150, S2, G180, dia5" /AntisenseName="ydzT" /AntisenseCor="-2.9485116084752801E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="0.23100000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S210" CDS complement(565730..565888) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52563.1" /translation="MIYQDSSFIFEREDGHPQLRKVIETRLKRLLKKAGIKRMSPPTL LGIPIPPY*" /label="ydzT CDS" gene complement(565730..565888) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /pseudo /label="ydzT gene" CDS complement(565933..566061) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52564.1" /translation="MISQVTKTLYTPNNQIEKYQLLTPKTTGSVDIVRIDETMSIY*" /label="ydzT CDS" gene complement(565933..566061) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /pseudo /label="ydzT gene" CDS complement(566154..566363) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52565.1" /translation="MYEDRTLELNEQYSHNCLGGIHACGRMIFRKAKTQGIIKMNPTG DFQLPKKQQSIGKRGADTFSKARSI*" /label="ydzT CDS" gene complement(566154..566363) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /pseudo /label="ydzT gene" CDS complement(566356..566661) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); N-terminal part of YdzT; defective prophage 3" /db_xref="PSEUDO:CAX52566.1" /translation="MELSYLLGIDPLTKKRLEISKGRFKTKKEAPVAARHVELQNDNG TFIKESDMPFKTFAKGWLKIYNRSGVKISSVRASEKKMMHFIAVLGQYPISKTQKNV* " /label="ydzTn CDS" gene complement(566356..566661) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /pseudo /label="ydzTn gene" SCAR join(566832,566839) /created_by="AR/SM" /note="deletion occured in betwen marked nucleotides" /label="Delta6_1" N_region 566833..566838 /note="KpnI site (GGTACC)" /created_by="User" /label="Delta6_1" CDS complement(566937..569426) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11118449, 11390381, 12897001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11118449, 11390381, 12897001; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the glucitol operon" /protein_id="NP_388495.1" /db_xref="EnsemblGenomes-Gn:BSU06140" /db_xref="EnsemblGenomes-Tr:CAB12433" /db_xref="GOA:P39143" /db_xref="InterPro:IPR002182" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR024123" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10178" /db_xref="UniProtKB/Swiss-Prot:P39143" /translation="MAELENRKQFAQMLAPGVKTLKLHPDYKVRRKKNEKTGQSYIDK IALQLGVSPNTIKSWIGQMGANYIPGRIDDGKLFGMIWIILEKTDLDIEWLTDLLEAT TIPVIKPALPVWAASCLKKAKILRKDGLFGAPSEGEIENVVKRLFHDRPGQETNALTE QPITHNLPSRWSGRFIGRSFDMEAIRQWMLSPSPVCLITGWAGMGKTTIALEAAYSCV DDTSVWPAFNSIIWVSADWKGLSFSDFLNTIAYQLGRKEQIDKSINVKRFVVRNALAN YTREKPILLIVDSIDTAERDIHEFITSLPQGVKVLLTARENVKQTYRESFGEMTAIQL SGLDQTDAHEFFQQEVHHCLQTCNLPRKREKLEQLLHLSSDLKNEFISATAGNPKAMA LSIAYMSDDDIPAQQLIHELGKAGYSLLELFEFLFGRTWDRCNEDTRKLWQTLCFFSK PPDEKSLAAAAGLDARRFHYAMEQMRSYALIQPERSQGRTQYLAHQTVVAYGEQHLSE QHEYEKEARNRWAHYYIDYAETHLKREQPNSIYWSYLLGRNLDQMKQEWPNILKVIQW ASETEQKEILIELITRISHFLSRINLPLRIEYGRKAADAAHHLGQHTREAYFRIDTSG WALMEVNDLDGALQQIEAGLKILEQSDAHDAYDLKVWGHALKARLFLKDGQQEKAETI LNEIENQPISPTIQHRVLLVRGDLSFARGYHVEAIQLYEAANEISSTYGGEKTIEAYF NLGVAYVKCDQFEKAEEAFEQMLYDKHNANQVELIYYHYGMAQLLYRKGEKTKAVESN QKAIRLIDSWEPAIGIRGEVERLARATKENE*" /label="gutR CDS" gene complement(566937..569426) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /label="gutR gene" downshifts complement(566959) /Source="Nicolas_upshifts" /id="D298" /incds=0 /nref=56 /ntot=209 /MaxReadThrough="0.69715" /MaxDrop="4.256" /score="0.285109352" /energy="-13.9" /TU="NA" /idTUdmin="U474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(569440..569459) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(569466) /Source="Nicolas_upshifts" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(569473..569480) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 569529..569530 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 569545..569627 /Source="Nicolas_S_feature" /locus_tag="new_667383_667465" /HighExp="Lbstat, BI, M40t90, Mt0, M0t90, dia5, dia0, Lbexp, Lbtran, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.848" /TUlongSig="NA" /TUlongPSig="NA" /label="S220" upshifts 569545 /Source="Nicolas_upshifts" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 569546..569565 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 569628..570689 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /EC_number="1.1.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1460002, 8195086, 8195087, 12897001, 19784641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1460002, 8195086, 8195087, 12897001, 19784641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucitol (sorbitol) dehydrogenase" /protein_id="NP_388496.1" /db_xref="EnsemblGenomes-Gn:BSU06150" /db_xref="EnsemblGenomes-Tr:CAB12434" /db_xref="GOA:Q06004" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10177" /db_xref="UniProtKB/Swiss-Prot:Q06004" /translation="MTHTVPQNMKAAVMHNTREIKIETLPVPDINHDEVLIKVMAVGI CGSDLHYYTNGRIGNYVVEKPFILGHECAGEIAAVGSSVDQFKVGDRVAVEPGVTCGR CEACKEGRYNLCPDVQFLATPPVDGAFVQYIKMRQDFVFLIPDSLSYEEAALIEPFSV GIHAAARTKLQPGSTIAIMGMGPVGLMAVAAAKAFGAGTIIVTDLEPLRLEAAKKMGA THIINIREQDALEEIKTITNDRGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPSQ NEIPLNVPFIADNEIDIYGIFRYANTYPKGIEFLASGIVDTKHLVTDQYSLEQTQDAM ERALQFKNECLKVMVYPNR*" /label="gutB CDS" gene 569628..570689 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /label="gutB gene" CDS 570763..572154 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897001, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+-glucitol symporter; prophage region 3" /protein_id="NP_388497.1" /db_xref="EnsemblGenomes-Gn:BSU06160" /db_xref="EnsemblGenomes-Tr:CAB12435" /db_xref="GOA:O34368" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12795" /db_xref="UniProtKB/Swiss-Prot:O34368" /translation="MIGTEKVTALKAKHQSKSSTGLSWFERIGYGFGDMSYNIIFQFV NAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWV AFPFALFTFLCFTTPHFGETGNMVYAYVTYILLGMSFSMQTIPVNSLTGRMTNSVEER TVLTTTRMILVYIGILLSISCATPLATAIGGEDQAFGFQMTALIYAAVSIVLNLFSFF TVRERIQPKKRKKQGIKKTLSVLFKNKPLLMLISSFLAFAIGFNIKLSTMVYYFTYNV NHKEFVFMGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAALSLISYAGLHFTPYSS IPLIFIWLFASGFFTTPLNTLAWGMVADCVDYAEWKTGIRADGVVISSMSFINKLGVA LAGSFSAIYLGIAGYVANTDQTVASLNAIKNMNALIPGFFILLSIILIAFYPLTEKRY KHIISELEQRSAR*" /label="gutP CDS" gene 570763..572154 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /label="gutP gene" promotor_-35 572181..572188 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 572202..572221 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 572207 /Source="Nicolas_upshifts" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="upshifts" CDS 572249..573211 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26483775, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar kinase (ribokinase family); prophage region 3" /protein_id="NP_388498.1" /db_xref="EnsemblGenomes-Gn:BSU06170" /db_xref="EnsemblGenomes-Tr:CAB12436" /db_xref="GOA:O34768" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12796" /db_xref="UniProtKB/Swiss-Prot:O34768" /translation="MRSHSVVCIGELLIDFFCTDVDVDLMEGRQFLKSAGGAPANVSA AIAKLGGDAAFSGKVGKDPFGYFLKRTLDAVHVDTSMLVMDEKAPTTLAFVSLKQNGE RDFVFNRGADALFTLEDIDQEKLNEAKILHFGSATALLSDPFCSAYLRLMSIAKDNGQ FISFDPNYREDLWRGRVSEFVSVAKKAIAVSDFVKVSDEELEIISGVKDHEKGVAILH EIGANIVAVTLGKSGTLLSNGKDREIIPSIPVTSIDSTGAGDAFVGAALYQLANTDQI QSVDADFVKLREIVAFANKVGALVCTKIGAIDALPSLDEIGVSL*" /label="ydjE CDS" gene 572249..573211 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /label="ydjE gene" downshifts 573196 /Source="Nicolas_upshifts" /id="D299" /incds=0 /nref=86 /ntot=213 /MaxReadThrough="2.99546" /MaxDrop="4.52045" /score="16.4550614" /energy="-14" /TU="NA" /idTUdmin="U475" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 573336..573345 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 573352 /Source="Nicolas_upshifts" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 573358..573373 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 573407..574090 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11454200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11454200; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage shock protein A homolog regulator; prophage region 3" /protein_id="NP_388499.1" /db_xref="EnsemblGenomes-Gn:BSU06180" /db_xref="EnsemblGenomes-Tr:CAB12437" /db_xref="GOA:P54617" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG12797" /db_xref="UniProtKB/Swiss-Prot:P54617" /translation="MSIIGRFKDIMSANINALLDKAENPEKMVDQYLRNMNSDLAKVK AETAAVMAEEQRAKREYHECQADMEKMESYAMKALQAGNESDARKFLERKTSLESKLS ELQAANQIAATNAAQMRKMHDKLVSDIGELEARKNMIKAKWAVAKTQERMNKLGASVS STSQSMSAFGRMEDKVNKALDQANAMAELNSAPQDDMADLSAKYDTGGSSQVDDELAA LKAKMMLDK*" /label="pspA CDS" gene 573407..574090 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /label="pspA gene" S_feature 574091..574155 /Source="Nicolas_S_feature" /locus_tag="new_671929_671993" /HighExp="Salt, S0, aero, T-0.40H, T-1.40H, SMMPr, T-1.10H, T0.0H, Cold, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S221" CDS 574156..575181 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /function="16.5: Explore" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage replication protein; prophage region 3" /protein_id="NP_388500.1" /db_xref="EnsemblGenomes-Gn:BSU06190" /db_xref="EnsemblGenomes-Tr:CAB12438" /db_xref="GOA:O34434" /db_xref="InterPro:IPR013137" /db_xref="SubtiList:BG12798" /db_xref="UniProtKB/Swiss-Prot:O34434" /translation="MIISYKCPNCGSDMAFDSETGSLSCSSCGRQDNIESLPKENIAA RFSDDEAKEYQCKNCGAVLITEAETTATTCSFCGGAAILADRLSGHLAPAKVIPFTIS KQEAEQAFRKWCKKGLLTPRGFMSADRIKSITGMYIPFWMFDLNSEVQVRANCTRVHQ YEEGDYICTETEHFEAFRDINLDYLKIPVDASEKMKDELMDKLEPYSYEELKDFQTAY LAGYIAEKYNYTDEELFPRAKEKISSYIDSYIHSTFSGYTSVNVRDKHIHTKNVNSFY VLLPVWMVSYDYERAEHIFAMNGQTGKVVGKPPISRGKVAAWFSGIAGGTFLALKLVS LMMGGGF*" /label="ydjG CDS" gene 574156..575181 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /label="ydjG gene" CDS 575181..575945 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388501.1" /db_xref="EnsemblGenomes-Gn:BSU06200" /db_xref="EnsemblGenomes-Tr:CAB12439" /db_xref="GOA:O35004" /db_xref="InterPro:IPR007621" /db_xref="SubtiList:BG12799" /db_xref="UniProtKB/Swiss-Prot:O35004" /translation="MRGFFGKAIFVVLAVFIMMPLLGIEAVRASELQQHVYDRAHLLS KAEIGKLESLSAKLGAKRDTDFIIITTKSTNGEDIADYTGDFYDRYGKGSTAILTIDM TNREVFIAGFKKAEQYLDNSRLNSIRNTISSDLSNENYFEAFETYIQLSYKDMGIKPG VNPDNIFFTWWFQLIAAIAVGGIAVSIMLYHAGGKVTVNGSTYMDQRTSDVIDQYDTY IRTTVTRERKPSDKDSGSDGGVTKGGTSYSGSRGSF*" /label="ydjH CDS" gene 575181..575945 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /label="ydjH gene" CDS 575976..576947 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388502.1" /db_xref="EnsemblGenomes-Gn:BSU06210" /db_xref="EnsemblGenomes-Tr:CAB12440" /db_xref="InterPro:IPR033880" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG12800" /db_xref="UniProtKB/Swiss-Prot:O34789" /translation="MSFFRNQLANVVEWEEFRDDMIFYKWNNREIKKGSRLIIRPGQD AVFLNNGRVEGVFQDDGDYDIESEIIPFLSTLKGFKFGFNSGMRAEVLFVNTKEFTVR WGTKQAINIPAAGMPGGMPIRANGTFNFKVQDYISLIDKIAGVKDQYFVEDIKTRIIS ILDQLLMKWITREGKDMFNLQANAFDIAKGIQEDLDMQLISDGMTVTGFQIMSFNYPQ EVQDMITKNASYGMVGDVNRYQQISMTDGMASGKMSGSGAASDMAGMMMGMNMANQMM NQMNQNQQAQSSGPQSTGSGSKPNFCPNCGTKTGEANFCPNCGQKLV*" /label="ydjI CDS" gene 575976..576947 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /label="ydjI gene" downshifts 576937 /Source="Nicolas_upshifts" /id="D300" /incds=0 /nref=180 /ntot=247 /MaxReadThrough="2.71622" /MaxDrop="5.81579" /score="16.72046" /energy="-11.1" /TU="U477" /idTUdmin="U477" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 576981 /Source="Nicolas_upshifts" /id="D301" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="2.13813" /MaxDrop="3.25329" /score="16.72046" /energy="-11.1" /TU="NA" /idTUdmin="U477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(576994..578019) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane associated potassium channel; prophage region 3" /protein_id="NP_388503.1" /db_xref="EnsemblGenomes-Gn:BSU06220" /db_xref="EnsemblGenomes-Tr:CAB12441" /db_xref="GOA:O34733" /db_xref="InterPro:IPR013099" /db_xref="SubtiList:BG12801" /db_xref="UniProtKB/Swiss-Prot:O34733" /translation="MNEGYIIAGLLLLTAGMIDFLWTTLWLESGAGPITRCLSAWLWK GCRKISGDHAKVLSMAGPLLLCLTLVIWISLFWSGWVLIYSSDPHSLMETQSKEPASW SDRIYFSGYVMFTLGNGDLAPNGGLWKLVTIIETAQGLLTITFSVTYLISVLSAVNQK RSFAQSVLSLGHDGTEIVHNAWNGKDFHDIDFLLVAASSELGKLTAQHNAFPILHFYH STQHQESSIIAVAVLDEALTIFKYGIPEQYQPNQLHIKEARSSIKNYLDTVHTAYIHP AEQAPPEPDISKLQQSGIPALSKQTFQIAVNSIKERRQLLLGIIQAGARKWPVQEQAI GNAYSPK*" /label="ydjJ CDS" gene complement(576994..578019) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /label="ydjJ gene" promotor_-10 complement(578051..578070) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(578069) /Source="Nicolas_upshifts" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(578084..578090) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 578279..578286 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 578299 /Source="Nicolas_upshifts" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="upshifts" S_feature 578301..578603 /Source="Nicolas_S_feature" /locus_tag="new_676139_676441" /HighExp="M0t90, M40t90, Lbtran, T0.30H, BI, T1.0H, M9-stat, S1, T1.30H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.28450700000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S222" promotor_-10 578301..578320 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 578604..580025 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="myo-inositol transporter" /protein_id="NP_388504.1" /db_xref="EnsemblGenomes-Gn:BSU06230" /db_xref="EnsemblGenomes-Tr:CAB12442" /db_xref="GOA:O34718" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12802" /db_xref="UniProtKB/Swiss-Prot:O34718" /translation="MNKQGNQMSFLRTIILVSTFGGLLFGYDTGVLNGALPYMGEPDQ LNLNAFTEGLVTSSLLFGAALGAVFGGRMSDFNGRRKNILFLAVIFFISTIGCTFAPN VTVMIISRFVLGIAVGGASVTVPAYLAEMSPVESRGRMVTQNELMIVSGQLLAFVFNA ILGTTMGDNSHVWRFMLVIASLPALFLFFGMIRMPESPRWLVSKGRKEDALRVLKKIR DEKRAAAELQEIEFAFKKEDQLEKATFKDLSVPWVRRIVFIGLGIAIVQQITGVNSIM YYGTEILRNSGFQTEAALIGNIANGVISVLATFVGIWLLGRVGRRPMLMTGLIGTTTA LLLIGIFSLVLEGSPALPYVVLSLTVTFLAFQQGAISPVTWLMLSEIFPLRLRGLGMG VTVFCLWMVNFAVSFTFPILLAAIGLSTTFFIFVGLGICSVLFVKRFLPETKGLSLEQ LEENFRAYDHSGAKKDSGAEVIG*" /label="iolT CDS" gene 578604..580025 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /label="iolT gene" downshifts 580017 /Source="Nicolas_upshifts" /id="D302" /incds=0 /nref=11 /ntot=24 /MaxReadThrough="2.82455" /MaxDrop="8.02371" /score="11.3880907" /energy="-11.2" /TU="NA" /idTUdmin="U479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(580073) /Source="Nicolas_upshifts" /id="D303" /incds=0 /nref=242 /ntot=272 /MaxReadThrough="1.00274" /MaxDrop="9.32541" /score="13.6781112" /energy="-11.2" /TU="NA" /idTUdmin="U482" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(580073..581113) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /EC_number="1.1.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12469342, 18820069, 24525333, 26428232, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12469342, 18820069, 24525333, 26428232, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin reductase/2,3-butanediol dehydrogenase" /protein_id="NP_388505.1" /db_xref="EnsemblGenomes-Gn:BSU06240" /db_xref="EnsemblGenomes-Tr:CAB12443" /db_xref="GOA:O34788" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12803" /db_xref="UniProtKB/Swiss-Prot:O34788" /translation="MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEY LGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATHG HQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYA VRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVD PSKTDDVVAEIAERTGGGVDVAFEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIH PNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIVLDDLIEEGFGALIK EKSQVKILVRPN*" /label="bdhA CDS" gene complement(580073..581113) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /label="bdhA gene" promotor_-35 580653..580662 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 580676..580695 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 580677..581212 /Source="Nicolas_S_feature" /locus_tag="new_678515_679050" /HighExp="C30, Gly, S6, C90, S8, BT, S7, Sw, Fru, Lbstat" /AntisenseName="bdhA" /AntisenseCor="-0.174163895138467" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S223" upshifts 580677 /Source="Nicolas_upshifts" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(581114..581408) /Source="Nicolas_S_feature" /locus_tag="new_678952_679246_c" /HighExp="Lbtran, BI, T1.0H, M40t90, LBGstat, LoTm, T0.30H, LPhT, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S224" misc_feature 581213..581232 /Source="Nicolas_upshift_promotors" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 581214..581511 /Source="Nicolas_S_feature" /locus_tag="new_679052_679349" /HighExp="G180, Paraq, Oxctl, H2O2, G135, G150, MG 5, C30, UNK1, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S225" upshifts 581214 /Source="Nicolas_upshifts" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="upshifts" misc_feature complement(581403..581417) /Source="Nicolas_upshift_promotors" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(581408) /Source="Nicolas_upshifts" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 581510..581529 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 581513 /Source="Nicolas_upshifts" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="upshifts" CDS 581552..581923 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /experiment="publication(s) with functional evidences, PMID:17581128, 20487291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17581128, 20487291; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein involved in cell wall metabolism" /protein_id="NP_388506.1" /db_xref="EnsemblGenomes-Gn:BSU06250" /db_xref="EnsemblGenomes-Tr:CAB12444" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG11036" /db_xref="UniProtKB/Swiss-Prot:P40775" /translation="MLKKVILAAFILVGSTLGAFSFSSDASAKHVNGNITWYNGVGKK GSSGKKLGHWDCATKIGFDVPRNGTKIRAYAKAKPKKVITVYKNDVGRMPNAVLDVSP KAFKALGYPLSKGKVAGHYSY*" /label="walM CDS" gene 581552..581923 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /label="walM gene" downshifts 581909 /Source="Nicolas_upshifts" /id="D304" /incds=0 /nref=5 /ntot=52 /MaxReadThrough="5.74148" /MaxDrop="2.8439" /score="-1.55787542" /energy="-7.4" /TU="U483" /idTUdmin="U481" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS 581989..583035 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388507.1" /db_xref="EnsemblGenomes-Gn:BSU06260" /db_xref="EnsemblGenomes-Tr:CAB12445" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12804" /db_xref="UniProtKB/Swiss-Prot:O34353" /translation="MKKRIILLLAVIIAAAAAGVAFYVAKDKGHEKAADVSVNTESGD ELLVSITDTDLLTKYYENDKVIHEEKLTSYPAFALDQKQQVLYYTGNNEQNEMRLFKL DLKSHKKTMLYKGAESADSLFLSKDRSTIYFRLGKADESNFRIAAFDLKTKKYKNLYP AANDQDDTVSSFFYNQKNDSFALLHYSVEEDYKKTDEANEKGIDPEPTTIHFAEGRQN KFNELKSLNQFISDIAVSDDDKRILFTSYTQKGTEQTASIQMLNADTKKYESIISNQK SFKLLIDAQPQFSKDGKNIYFLAEAKGAKKLKDETGREAKVRTIYSYSLENKTFKKVW ENPNGIINSFFVIN*" /label="ydjN CDS" gene 581989..583035 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /label="ydjN gene" downshifts 583009 /Source="Nicolas_upshifts" /id="D305" /incds=0 /nref=41 /ntot=177 /MaxReadThrough="1.73572" /MaxDrop="4.49184" /score="21.8200083" /energy="-13.9" /TU="NA" /idTUdmin="U483" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(583069..583227) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097689.1" /db_xref="EnsemblGenomes-Gn:BSU06269" /db_xref="EnsemblGenomes-Tr:CAX52576" /db_xref="GOA:O24817" /db_xref="UniProtKB/Swiss-Prot:O24817" /translation="MISNQQQKDLKKRAAFKKLNVAMNSYVELLFLSVPLIHIFKWLG SLALHLIH*" /label="ydzJ CDS" gene complement(583069..583227) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /label="ydzJ gene" downshifts complement(583085) /Source="Nicolas_upshifts" /id="D306" /incds=0 /nref=23 /ntot=155 /MaxReadThrough="0.7906" /MaxDrop="3.61386" /score="9.10659473" /energy="-10.1" /TU="NA" /idTUdmin="U487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(583284..583416) /Source="Nicolas_S_feature" /locus_tag="new_681122_681254_c" /HighExp="LoTm, S8, S5, S6, S4, B36, S7, Cold, B60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigWXY" /TUshortPSig="0.994, 1, 1" /TUlongSig="SigK" /TUlongPSig="0.994" /label="S226" downshifts complement(583327) /Source="Nicolas_upshifts" /id="D307" /incds=0 /nref=57 /ntot=272 /MaxReadThrough="3.03092" /MaxDrop="6.46708" /score="5.41743429" /energy="-8.4" /TU="U484,U486,U487" /idTUdmin="U484" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(583417..583626) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28197687" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388508.1" /db_xref="EnsemblGenomes-Gn:BSU06270" /db_xref="EnsemblGenomes-Tr:CAB12446" /db_xref="InterPro:IPR025916" /db_xref="SubtiList:BG12805" /db_xref="UniProtKB/Swiss-Prot:O34759" /translation="MSYYNKRNQEPLPKEDVSTWECTKEDCNGWTRKNFASSDTPLCP LCGSKMVDGIRSLVNLQNNSQTKTS*" /label="ydjO CDS" gene complement(583417..583626) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /label="ydjO gene" promotor_-10 complement(583659..583678) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(583670) /Source="Nicolas_upshifts" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" CDS complement(583709..584524) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9987136; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacrylate hydrolase" /protein_id="NP_388509.1" /db_xref="EnsemblGenomes-Gn:BSU06280" /db_xref="EnsemblGenomes-Tr:CAB12447" /db_xref="GOA:O34592" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12806" /db_xref="UniProtKB/Swiss-Prot:O34592" /translation="MPYIILEDQTRLYYETHGSGTPILFIHGVLMSGQFFHKQFSVLS ANYQCIRLDLRGHGESDKVLHGHTISQYARDIREFLNAMELDHVVLAGWSMGAFVVWD YLNQFGNDNIQAAVIIDQSASDYQWEGWEHGPFDFDGLKTAMHAIQTDPLPFYESFIQ NMFAEPPAETETEWMLAEILKQPAAISSTILFNQTAADYRGTLQNINVPALLCFGEDK KFFSTAAGEHLRSNIPNATLVTFPKSSHCPFLEEPDAFNSTLLSFLDGVIGKS*" /label="ydjP CDS" gene complement(583709..584524) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /label="ydjP gene" promotor_-35 584351..584360 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 584373..584392 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 584373 /Source="Nicolas_upshifts" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(584537..585526) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388510.1" /db_xref="EnsemblGenomes-Gn:BSU06290" /db_xref="EnsemblGenomes-Tr:CAB12448" /db_xref="InterPro:IPR025062" /db_xref="SubtiList:BG12210" /db_xref="UniProtKB/Swiss-Prot:O34803" /translation="MLTHDLHEKTKHYISIYAELKTKLKWKVSHDQILMLISSAYIVN KREFDFQRFYDLSSYIKSNIGSFSTLNSHHRFTVASILDIHFQHEAKQTFQTFIDVYN EMVKLGYKRDMFTYLSALILLTGKSETTNQKEQMNMGLAVYQQMKKNHYFLTSTQNVP LAVLLGENGKGLQALQKAETCYQLLAANGFKKGQYLHQVSHILALQSEKEPEMLVSAC KQIYQSITESVKKTKDYHYPDLALLTFLEEPDIKTVLCITDELNQEKAFKWQKEMNFK IAVSLYLSEHMEKNLLMESGLYTAIETVIQAQQAAATAAIISSTAASHTHDGN*" /label="yeaA CDS" gene complement(584537..585526) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /label="yeaA gene" promotor_-10 complement(585391..585409) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(585399) /Source="Nicolas_upshifts" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(585425..585430) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(585548..585563) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(585569) /Source="Nicolas_upshifts" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(585575..585584) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(585624..587165) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /EC_number="1.3.3.5" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="outer spore coat copper-dependent promiscuous laccase" /protein_id="NP_388511.1" /db_xref="EnsemblGenomes-Gn:BSU06300" /db_xref="EnsemblGenomes-Tr:CAB12449" /db_xref="GOA:P07788" /db_xref="InterPro:IPR001117" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011706" /db_xref="InterPro:IPR011707" /db_xref="PDB:1GSK" /db_xref="PDB:1OF0" /db_xref="PDB:1W6L" /db_xref="PDB:1W6W" /db_xref="PDB:1W8E" /db_xref="PDB:2BHF" /db_xref="PDB:2WSD" /db_xref="PDB:2X87" /db_xref="PDB:2X88" /db_xref="PDB:3ZDW" /db_xref="PDB:4A66" /db_xref="PDB:4A67" /db_xref="PDB:4A68" /db_xref="PDB:4AKO" /db_xref="PDB:4AKP" /db_xref="PDB:4AKQ" /db_xref="PDB:4Q89" /db_xref="PDB:4Q8B" /db_xref="PDB:4YVN" /db_xref="PDB:4YVU" /db_xref="SubtiList:BG10490" /db_xref="UniProtKB/Swiss-Prot:P07788" /translation="MTLEKFVDALPIPDTLKPVQQSKEKTYYEVTMEECTHQLHRDLP PTRLWGYNGLFPGPTIEVKRNENVYVKWMNNLPSTHFLPIDHTIHHSDSQHEEPEVKT VVHLHGGVTPDDSDGYPEAWFSKDFEQTGPYFKREVYHYPNQQRGAILWYHDHAMALT RLNVYAGLVGAYIIHDPKEKRLKLPSDEYDVPLLITDRTINEDGSLFYPSAPENPSPS LPNPSIVPAFCGETILVNGKVWPYLEVEPRKYRFRVINASNTRTYNLSLDNGGDFIQI GSDGGLLPRSVKLNSFSLAPAERYDIIIDFTAYEGESIILANSAGCGGDVNPETDANI MQFRVTKPLAQKDESRKPKYLASYPSVQHERIQNIRTLKLAGTQDEYGRPVLLLNNKR WHDPVTETPKVGTTEIWSIINPTRGTHPIHLHLVSFRVLDRRPFDIARYQESGELSYT GPAVPPPPSEKGWKDTIQAHAGEVLRIAATFGPYSGRYVWHCHILEHEDYDMMRPMDI TDPHK*" /label="cotA CDS" gene complement(585624..587165) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /label="cotA gene" downshifts complement(585637) /Source="Nicolas_upshifts" /id="D308" /incds=0 /nref=46 /ntot=93 /MaxReadThrough="2.97674" /MaxDrop="5.60726" /score="22.3755425" /energy="-9.1" /TU="U488" /idTUdmin="U488" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(587196..587215) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-10" upshifts complement(587210) /Source="Nicolas_upshifts" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="upshifts" promotor_-35 complement(587229..587238) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-35" CDS complement(587317..588726) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16547045, 16850406, 8951816, 9677314, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16547045, 16850406, 8951816, 9677314, 24142252; Product type t : transporter" /codon_start=1 /transl_table=11 /product="gamma-aminobutyrate (GABA) permease; proline permease" /protein_id="NP_388512.2" /db_xref="EnsemblGenomes-Gn:BSU06310" /db_xref="EnsemblGenomes-Tr:CAB12450" /db_xref="GOA:P46349" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="InterPro:IPR011265" /db_xref="SubtiList:BG11328" /db_xref="UniProtKB/Swiss-Prot:P46349" /translation="MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPG AVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYAHDAIGPWAGFTIGWLYWFFWVI VIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVT IIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIV AIAAGETSNPIESVTKATRSVVWRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEH IGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRRFMKLSKKGVPVQA IVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPE ALKIKMWLFPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRK VSEKAAANPVTQQQPDILP*" /label="gabP CDS" gene complement(587317..588726) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /label="gabP gene" downshifts complement(587331) /Source="Nicolas_upshifts" /id="D309" /incds=0 /nref=124 /ntot=216 /MaxReadThrough="3.22899" /MaxDrop="5.0359" /score="18.985683" /energy="-13.5" /TU="U489" /idTUdmin="U489" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(588764..589051) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097690.1" /db_xref="EnsemblGenomes-Gn:BSU06319" /db_xref="EnsemblGenomes-Tr:CAX52577" /db_xref="UniProtKB/Swiss-Prot:C0H3X2" /translation="MIHPPQKNSDEGTLFLSSNLFAPPKIPSNPRTPVLLAFYRIVNI TQNHTANKKRNIFSTHSLKAQTKHYKFEISWYIFLHEFSTNCIFMIEFQLS*" /label="ydzX CDS" gene complement(588764..589051) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /label="ydzX gene" misc_feature complement(588767..588786) /Source="Nicolas_upshift_promotors" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(588781) /Source="Nicolas_upshifts" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="upshifts" promotor_-35 589057..589064 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 589080..589099 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 589081 /Source="Nicolas_upshifts" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="upshifts" CDS 589124..589996 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="secondary Mn(II) exporter, promiscuous" /protein_id="NP_388513.1" /db_xref="EnsemblGenomes-Gn:BSU06320" /db_xref="EnsemblGenomes-Tr:CAB12451" /db_xref="GOA:P46348" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11329" /db_xref="UniProtKB/Swiss-Prot:P46348" /translation="MERYDELKKGESGALVSIAAYLVLSAIKLIIGYLFHSEALTADG LNNTTDIIASVAVLIGLRISQKPPDEDHPYGHFRAETIASLIASFIMMVVGLQVLFSA GESIFSAKQETPDMIAAWTAAGGAVLMLIVYRYNKRLAKKVKSQALLAAAADNKSDAF VSIGTFIGIVAAQFHLAWIDTVTAFVIGLLICKTAWDIFKESSHSLTDGFDIKDISAY KQTIEKISGVSRLKDIKARYLGSTVHVDVVVEVSADLNITESHDIANEIERRMKEEHA IDYSHVHMEPLEQK*" /label="mneS CDS" gene 589124..589996 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /label="mneS gene" downshifts 589961 /Source="Nicolas_upshifts" /id="D310" /incds=0 /nref=2 /ntot=88 /MaxReadThrough="1.72291" /MaxDrop="2.86431" /score="24.8167732" /energy="-10.2" /TU="U490" /idTUdmin="U490" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(590236) /Source="Nicolas_upshifts" /id="D311" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="0.65827" /MaxDrop="3.33542" /score="-0.424989042" /energy="-12.9" /TU="NA" /idTUdmin="U489" /TUdmin="-3015" /isTUend="FALSE" /label="downshifts" misc_feature 590290..590309 /Source="Nicolas_upshift_promotors" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 590300 /Source="Nicolas_upshifts" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="upshifts" CDS 590346..591308 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21907250, 26933057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative MoxR-like ATPase" /protein_id="NP_388514.2" /db_xref="EnsemblGenomes-Gn:BSU06330" /db_xref="EnsemblGenomes-Tr:CAB12452" /db_xref="GOA:P94474" /db_xref="InterPro:IPR011703" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12211" /db_xref="UniProtKB/Swiss-Prot:P94474" /translation="MAYQEDLHPLLGKAVEHINRVMVGKRDIAILSLAALLAKGHVLL EDVPGVGKTMMVRALAKSIGADFKRIQFTPDLLPSDVTGVSIYNAKTMEFEYRPGPIM GNIVLADEINRTSPKTQSALLEAMEEGSVTVDGHTMQLADPFFVMATQNPVEYEGTYP LPEAQLDRFLFKLRMGYPSFNEELDVLSLQEKSHPIETLEPVIAKEDFIFLQREVQNV RADDSIKEYIVEIVQKTRQHPSVQLGVSPRGSIALMKAAQAYALLHHRDYVIPDDIQY LAPFTLPHRMMLHPEAKFEGIQAEAIVREIMSAVKVPVQRSAVR*" /label="yeaC CDS" gene 590346..591308 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /label="yeaC gene" CDS 591308..592504 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388515.2" /db_xref="EnsemblGenomes-Gn:BSU06340" /db_xref="EnsemblGenomes-Tr:CAB12453" /db_xref="InterPro:IPR002881" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12212" /db_xref="UniProtKB/Swiss-Prot:P94475" /translation="MNKKWQWLVYGWKLIILTLLTAAVFSYAMFQGGFVSWFLFYAFL PFVLYAGLLALYPLRSFQASRQMDKTQLHAGDRLGVTVTLRRKLPFPLMYMVIEDCLP EGIESLNRDGAAAKRLVFPWFKRSMTMSYELARVPRGEHHFHSVRVRTGDVLGLIEKT AFFELDDTLFVYPFYQRFSYQVNERHQEDGVSGSSPIHQHHSSVAASVRNYQPGDRFA ALDWKTSARRSQLMTKEFEPSRSKNLFLLMDRFSSDAFEEVVSVTASILHSVLKNGAG AGLASIGKEKNIFPIQEGDQHFKHMLRHLAIAHCDAADPISRYAREELGKPSVRQADQ VVVTGQLTEDMLHLAEIGGGRVTVILAKEKDAELSQAENVMIERMMKRQIRVRIMRGG RVSRVV*" /label="yeaD CDS" gene 591308..592504 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /label="yeaD gene" CDS 592526..594739 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388516.2" /db_xref="EnsemblGenomes-Gn:BSU06350" /db_xref="EnsemblGenomes-Tr:CAB12454" /db_xref="GOA:P94476" /db_xref="InterPro:IPR002931" /db_xref="InterPro:IPR025403" /db_xref="InterPro:IPR036985" /db_xref="SubtiList:BG12213" /db_xref="UniProtKB/Swiss-Prot:P94476" /translation="MPHDDHKGSRLSLLLFYFLAFLLLWEWLRPLDSFTETKHTGFFS VFIGLTFLLTFFRMRWFVTVPFCVIFTLISIHILFYQGSIFDLSWVSSFLQDVYLNIT LIQSGQWNDMIPSFRTLLFFVLLWLLVYLLHYWVIYQRRILFFFLMTVAYITILDTFT PYDATFAVIRIVLIGFFMLGLLYLERIKLMERITLPKTSVLKWFLPLSVLVLAATGFG LAAPKSEPAWPDPVPFLKKITHQDRVSAGESKIGYGNHDESLGGPFQQDATPVFTWQG KERTYFRVETKDTYTGKGWIETDTGMSYQLSNGKVENLWFDHKVATERRTVRVKVDKH YGYNHLMYPIGAETIQPKQAVSLEMNGNTEQISPISEQAGEIRNMGNYTVTYNSPVYK LDELRKVKVRKNSEEYTFSDRYMQLPDSLPERVRTLAIKLTQDHDNMFDKVKAVEDYL GSNAFTYETENVTIPKNDEDYVDQFLFETKMGYCDNFSSAMVVLLRSAGIPARWVKGY TSGEYKEAGNKNGSIYEVTNNNAHSWVEVYFPEQGWVTFEPTKGFTNPAQFTSSDTKD SGSDSSSSPKKAKEKQKEEKKQPQKEEKQKEKREPAVSKKPSASHTNAGAGLYAALAV LAVLLVAAVLLYVFRSLWIPVFAVRKLKRRSDQHAFFEAYGALLKQLKRKGLPKRDSE TLRDYAKRIDEKYDIEDMSKLTLSYERALYRNEDSSALWNDSRELWENLIKRRWS*" /label="yebA CDS" gene 592526..594739 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /label="yebA gene" promotor_-35 594734..594741 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 594756..594775 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 594772..594901 /Source="Nicolas_S_feature" /locus_tag="new_692610_692739" /HighExp="G180, Oxctl, G135, LBGexp, G150, Paraq, C30, LPh, MG 25, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63292099999999996" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S227" upshifts 594772 /Source="Nicolas_upshifts" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="upshifts" CDS 594902..596443 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /EC_number="6.3.5.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1312531, 21856856; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP synthetase" /protein_id="NP_388517.2" /db_xref="EnsemblGenomes-Gn:BSU06360" /db_xref="EnsemblGenomes-Tr:CAB12455" /db_xref="GOA:P29727" /db_xref="InterPro:IPR001674" /db_xref="InterPro:IPR004739" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022955" /db_xref="InterPro:IPR025777" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10647" /db_xref="UniProtKB/Swiss-Prot:P29727" /translation="MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEE IKKMNPKGIILSGGPNSVYDENSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEAA SQREYGKANIRIEGTPDLFRDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMS KADKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECEGEWSMENFIEIEMQKIRETVGD KQVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNV IKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGIDYLAQGTLYTDIIE SGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFP GPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPDIRSVGVMGD ARTYDYTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPA TIEWE*" /label="guaA CDS" gene 594902..596443 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /label="guaA gene" downshifts 596429 /Source="Nicolas_upshifts" /id="D312" /incds=0 /nref=247 /ntot=268 /MaxReadThrough="2.12151" /MaxDrop="7.3702" /score="22.5795134" /energy="-18.5" /TU="NA" /idTUdmin="U492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 596550..596554 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-35" promotor_-10 596570..596589 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-10" upshifts 596580 /Source="Nicolas_upshifts" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="upshifts" misc_RNA 596587..596689 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswC RNA" gene 596587..596689 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /label="gswC gene" downshifts 596715 /Source="Nicolas_upshifts" /id="D313" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="8.01916" /MaxDrop="4.7859" /score="24.3821572" /energy="-11.3" /TU="U493" /idTUdmin="U492" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 596824..598146 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3110131, 11591660, 12923093, 15849754, 16850406, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 11591660, 12923093, 15849754, 16850406, 19446032; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_388518.1" /db_xref="EnsemblGenomes-Gn:BSU06370" /db_xref="EnsemblGenomes-Tr:CAB12456" /db_xref="GOA:O34987" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG12811" /db_xref="UniProtKB/Swiss-Prot:O34987" /translation="MKTFFQFDELGTSYRNEIIGGLTTFLSMAYILFVNPITLALESV KDFPEALRIDQGAVFTATALASAAGCILMGLIARYPIAIAPGMGLNAFFAFSVVLGMG ISWQAALSGVFISGLIFVALSLTGFREKIINAIPPELKLAVGAGIGLFITFVGLQGSG IITANPSTLVTIGNIHSGPVLLTIFGVIVTVILMVLRVNAGVFIGMLLTAVAGMIFGL VPVPTQIIGSVPSLAPTFGQAWIHLPDIFSVQMLIVILTFLFVGFFDTAGTLVAVATQ AGLMKENKLPRAGRALLADSSSIVIGAVLGTSTTTSYVESSSGVAAGARSGFAAIVTG ILFLLATFFSPLLSVVTSNVTAPALIIVGALMVAPLGKIAWDKFEVAVPAFLTMIMMP LTYSIATGIAIGFIFYPITMVCKGKAKEVHPIMYGLFVVFILYFIFLK*" /label="pbuG CDS" gene 596824..598146 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /label="pbuG gene" downshifts 598124 /Source="Nicolas_upshifts" /id="D314" /incds=0 /nref=47 /ntot=153 /MaxReadThrough="4.18958" /MaxDrop="4.86237" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 598167 /Source="Nicolas_upshifts" /id="D315" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="3.09696" /MaxDrop="3.87785" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-43" /isTUend="FALSE" /label="downshifts" promotor_-35 598196..598205 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 598216..598356 /Source="Nicolas_S_feature" /locus_tag="new_696054_696194" /HighExp="T1.30H, T1.0H, T2.0H, T0.30H, B60, T2.30H, T-0.40H, T0.0H, T3.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S228" upshifts 598216 /Source="Nicolas_upshifts" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 598218..598233 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 598357..599160 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388519.2" /db_xref="EnsemblGenomes-Gn:BSU06380" /db_xref="EnsemblGenomes-Tr:CAB12457" /db_xref="GOA:O34341" /db_xref="SubtiList:BG12812" /db_xref="UniProtKB/Swiss-Prot:O34341" /translation="MTEERKETFEEEINQSERIDADEEPLSRMSRKASRQSKQKQKQK QKPRQERGESTVKDKLASVWAAINRYCGFAFSILKSPAKTVVTDGFSHYKYGLISMLI FSIIFSIGNWFQLKASWNRPLGFGERHHAFYDGFLVVLVYLLIFFAVMVFAIWAVSRY MMKQKVTFREAAAVLGSLLVPVIAVSILWLIFAIVNIPMLTVLFTVLILFSIFFIIAL YVQRVYQAAQDAPIDYIYCVFAVVAIALLFTAVTWPFISEYITASLIPL*" /label="yebC CDS" gene 598357..599160 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /label="yebC gene" downshifts 599145 /Source="Nicolas_upshifts" /id="D316" /incds=0 /nref=218 /ntot=263 /MaxReadThrough="1.47691" /MaxDrop="7.03926" /score="33.0377004" /energy="-10.7" /TU="NA" /idTUdmin="U494" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 599228..599235 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 599249..599268 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 599255..599318 /Source="Nicolas_S_feature" /locus_tag="new_697093_697156" /HighExp="B60, S2, S7, S8, Lbstat, nit, S4, BC, BT, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S229" upshifts 599255 /Source="Nicolas_upshifts" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="upshifts" CDS 599319..599486 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388520.3" /db_xref="EnsemblGenomes-Gn:BSU06390" /db_xref="EnsemblGenomes-Tr:CAB12458" /db_xref="InterPro:IPR025072" /db_xref="SubtiList:BG12813" /db_xref="UniProtKB/Swiss-Prot:O34904" /translation="MADVLRRAINQKKQFLKTKLLLSEFYQGRGEQLADYTLSELEKE YKSLQKMKKEI*" /label="yebD CDS" gene 599319..599486 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /label="yebD gene" downshifts 599493 /Source="Nicolas_upshifts" /id="D317" /incds=0 /nref=64 /ntot=163 /MaxReadThrough="2.85884" /MaxDrop="5.66286" /score="29.2645456" /energy="-9" /TU="NA" /idTUdmin="U495" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 599537..599543 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 599558..599576 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 599561..599647 /Source="Nicolas_S_feature" /locus_tag="new_697399_697485" /HighExp="Etha, Gly, M9-stat, Sw, B60, S4, S6, LPhT, S3, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S230" upshifts 599561 /Source="Nicolas_upshifts" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 599626..599633 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 599647..599666 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 599649 /Source="Nicolas_upshifts" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="upshifts" CDS 599700..600254 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388521.2" /db_xref="EnsemblGenomes-Gn:BSU06400" /db_xref="EnsemblGenomes-Tr:CAB12459" /db_xref="GOA:O34624" /db_xref="InterPro:IPR019264" /db_xref="InterPro:IPR022930" /db_xref="SubtiList:BG12814" /db_xref="UniProtKB/Swiss-Prot:O34624" /translation="MMQTILSNGIAMVLIILIINIVYVSFFTIRMILTLKGQRYLAAG ISTIEILVYVTGLSLVLDNLDQIQNVIAYALGYGLGVIVGMKIEEKLALGYIMVNVIT KELDLDLPKQLREKGYGVTNWVAGGLEGDRTALQILTPRRYELQLYDTIKTLDSKAFI IAYEPKTIHGGFWVKAVKKRRIKE*" /label="yebE CDS" gene 599700..600254 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /label="yebE gene" CDS 600254..600451 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388523.1" /db_xref="EnsemblGenomes-Gn:BSU06410" /db_xref="EnsemblGenomes-Tr:CAB12461" /db_xref="InterPro:IPR025930" /db_xref="SubtiList:BG12816" /db_xref="UniProtKB/Swiss-Prot:O34700" /translation="MAKPKKKKFEVTEQQTIDAVLQQMKEEGYLPVRRMEEPIFMEKK ENGSIQIVPCGKKIVFEGKLI*" /label="yebG CDS" gene 600254..600451 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /label="yebG gene" downshifts 600441 /Source="Nicolas_upshifts" /id="D318" /incds=0 /nref=2 /ntot=91 /MaxReadThrough="2.80904" /MaxDrop="2.65424" /score="17.462689" /energy="-17.6" /TU="U496" /idTUdmin="U497" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 600497..600504 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 600519..600538 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 600521 /Source="Nicolas_upshifts" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 600531..600633 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswD RNA" gene 600531..600633 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /label="gswD gene" S_feature 600634..600773 /Source="Nicolas_S_feature" /locus_tag="new_698472_698611" /HighExp="MG 10, MG 15, MG t5, BMM, MG 25, MG 5, HPh, GM 45, GM 90, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S231" CDS 600774..601262 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /EC_number="5.4.99.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12787499, 16138311, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide mutase" /protein_id="NP_388524.1" /db_xref="EnsemblGenomes-Gn:BSU06420" /db_xref="EnsemblGenomes-Tr:CAB12462" /db_xref="GOA:P12044" /db_xref="InterPro:IPR000031" /db_xref="InterPro:IPR024694" /db_xref="InterPro:IPR033747" /db_xref="InterPro:IPR035893" /db_xref="SubtiList:BG10700" /db_xref="UniProtKB/Swiss-Prot:P12044" /translation="MQPLVGIIMGSTSDWETMKHACDILDELNVPYEKKVVSAHRTPD FMFEYAETARERGIKVIIAGAGGAAHLPGMTAAKTTLPVIGVPVQSKALNGMDSLLSI VQMPGGVPVATTSIGKAGAVNAGLLAAQILSAFDEDLARKLDERRENTKQTVLESSDQ LV*" /label="purE CDS" gene 600774..601262 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /label="purE gene" CDS 601255..602397 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /EC_number="6.3.4.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8998996, 9683488, 21931218, 25372694; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide synthase" /protein_id="NP_388525.2" /db_xref="EnsemblGenomes-Gn:BSU06430" /db_xref="EnsemblGenomes-Tr:CAB12463" /db_xref="GOA:P12045" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005875" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10701" /db_xref="UniProtKB/Swiss-Prot:P12045" /translation="MSKQIIYPGAVIGIIGGGQLGKMMAVSAKQMGYKVAVVDPVKDS PCGQVADVEITAHYNDREAIRKLAEISDIITYEFENIDYDALHWLKDHAYLPQGSELL LITQNRETEKKAIQSAGCEVAPYSIVKTKNELKQAVQELRLPAVLKTCRGGYDGKGQF VIKEEAQMEQAAALLEHGTCILESWVSFKMELSVIVVRSVNGEISTFPTAENIHHNNI LFQSIVPARVEKGIQQKAADLAVKLADELNLVGPLAVEMFLTEDGELLVNELAPRPHN SGHYTLDLCETSQFEQHIRAVCGLPLGKTDLLKPGMMVNLLGDEVKLVEEDPELLKEA KLYIYGKHEIKKGRKMGHITFMKQPEDEWIQEITNKWMNRDGGQAE*" /label="purK CDS" gene 601255..602397 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /label="purK gene" CDS 602394..603689 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /EC_number="4.3.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9622500, 9683488, 9890879, 11063569, 12787499; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate lyase" /protein_id="NP_388526.1" /db_xref="EnsemblGenomes-Gn:BSU06440" /db_xref="EnsemblGenomes-Tr:CAB12464" /db_xref="GOA:P12047" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004769" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR019468" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="PDB:1F1O" /db_xref="SubtiList:BG10702" /db_xref="UniProtKB/Swiss-Prot:P12047" /translation="MIERYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGVIPKED VKVMRENASFDINRILEIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTAL SYLLKQANDILLKDLERFVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEE MKRNLERFKQAKAGIEVGKISGAVGTYANIDPFVEQYVCEKLGLKAAPISTQTLQRDR HADYMATLALIATSIEKFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSEN MTGMARVIRGYMMTAYENVPLWHERDISHSSAERIILPDATIALNYMLNRFSNIVKNL TVFPENMKRNMDRTLGLIYSQRVLLALIDTGLTREEAYDTVQPKAMEAWEKQVPFREL VEAEEKITSRLSPEKIADCFDYNYHLKNVDLIFERLGLA*" /label="purB CDS" gene 602394..603689 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /label="purB gene" promotor_-10 complement(602699..602718) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(602720) /Source="Nicolas_upshifts" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(602733..602740) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 603763..604488 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /EC_number="6.3.2.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2495272, 9683488, 10784038, 12787499, 26118696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole succinocarboxamide synthetase" /protein_id="NP_388527.1" /db_xref="EnsemblGenomes-Gn:BSU06450" /db_xref="EnsemblGenomes-Tr:CAB12465" /db_xref="GOA:P12046" /db_xref="InterPro:IPR001636" /db_xref="InterPro:IPR018236" /db_xref="InterPro:IPR028923" /db_xref="InterPro:IPR033934" /db_xref="SubtiList:BG10703" /db_xref="UniProtKB/Swiss-Prot:P12046" /translation="MNIVKNELLYEGKAKKIYKTDDENTLYVVYKDSATAFNGEKKAE ISGKGRLNNEISSLIFKHLHAKGINNHFIERISETEQLIKKVTIVPLEVVVRNVVAGS MSKRLGIPEGTELEQPIIEFYYKDDALGDPLITEDHIWLLKAATPEQVETIKSITTIV NEELQSIFDDCHVRLIDFKLEFGLDAEGQVLLADEISPDTCRLWDKETNEKLDKDLFR RNLGSLTDAYEEIFNRLGGIHHV*" /label="purC CDS" gene 603763..604488 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /label="purC gene" CDS 604481..604735 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10784038, 12787499" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10784038, 12787499; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for phosphoribosylformylglycinamidine synthetase activity" /protein_id="NP_388528.1" /db_xref="EnsemblGenomes-Gn:BSU06460" /db_xref="EnsemblGenomes-Tr:CAB12466" /db_xref="GOA:P12049" /db_xref="InterPro:IPR003850" /db_xref="InterPro:IPR036604" /db_xref="PDB:1T4A" /db_xref="PDB:1TWJ" /db_xref="SubtiList:BG10704" /db_xref="UniProtKB/Swiss-Prot:P12049" /translation="MYKVKVYVSLKESVLDPQGSAVQHALHSMTYNEVQDVRIGKYME LTIEKSDRDLDVLVKEMCEKLLANTVIEDYRYEVEEVVAQ*" /label="purS CDS" gene 604481..604735 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /label="purS gene" CDS 604732..605415 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301530, 15301532, 10784038, 9683488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301530, 15301532, 10784038, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit I" /protein_id="NP_388529.1" /db_xref="EnsemblGenomes-Gn:BSU06470" /db_xref="EnsemblGenomes-Tr:CAB12467" /db_xref="GOA:P12041" /db_xref="InterPro:IPR010075" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10706" /db_xref="UniProtKB/Swiss-Prot:P12041" /translation="MKFAVIVLPGSNCDIDMYHAVKDELGHEVEYVWHEETSLDGFDG VLIPGGFSYGDYLRCGAIARFANIMPAVKQAAAEGKPVLGVCNGFQILQELGLLPGAM RRNKDLKFICRPVELIVQNDETLFTASYEKGESITIPVAHGEGNFYCDDETLATLKEN NQIAFTYGSNINGSVSDIAGVVNEKGNVLGMMPHPERAVDELLGSADGLKLFQSIVKN WRETHVTTA*" /label="purQ CDS" gene 604732..605415 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /label="purQ gene" CDS 605399..607627 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301532, 10784038, 9683488, 21671997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301532, 10784038, 9683488, 21671997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit II" /protein_id="NP_388530.2" /db_xref="EnsemblGenomes-Gn:BSU06480" /db_xref="EnsemblGenomes-Tr:CAB12468" /db_xref="GOA:P12042" /db_xref="InterPro:IPR010074" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10705" /db_xref="UniProtKB/Swiss-Prot:P12042" /translation="MSLLLEPSKEQIKEEKLYQQMGVSDDEFALIESILGRLPNYTEI GIFSVMWSEHCSYKNSKPILRKFPTSGERVLQGPGEGAGIVDIGDNQAVVFKIESHNH PSALEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAG YGNCIGIPTVGGEVQFDSSYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKT GRDGIHGATFASEEMSDSSEEKRSAVQVGDPFMEKLLLEACLEVIQCDALVGIQDMGA AGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTAYEMMLSESQERMLLVIERGREQEI IDIFDKYDLEAVSVGHVTDDKMLRLTHKGEVVCELPVDALAEEAPVYHKPSQEPAYYR EFLETDVPAPQIEDANEMLKALLQQPTIASKEWVYDQYDYMVRTNTVVAPGSDAGVLR IRGTKKALAMTTDCNARYLYLDPEVGGKIAVAEAARNIICSGAEPLAVTDNLNFGNPE KPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGTAIYPTPVIGMVGLIEDTA HITTQHFKQAGDLVYVIGETKPEFAGSELQKMTEGRIYGKAPQIDLDVELSRQKALLD AIKKGFVQSAHDVSEGGLGVAIAESVMTTENLGANVTVEGEAALLFSESQSRFVVSVK KEHQAAFEATVKDAVHIGEVTADGILAIQNQDGQQMIHAQTKELERVWKGAIPCLLKS KA*" /label="purL CDS" gene 605399..607627 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /label="purL gene" downshifts complement(605647) /Source="Nicolas_upshifts" /id="D319" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="0.69202" /MaxDrop="3.99287" /score="-6.56256716" /energy="-16.7" /TU="NA" /idTUdmin="U499" /TUdmin="-3147" /isTUend="FALSE" /label="downshifts" CDS 607603..609033 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /EC_number="2.4.2.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 10049369, 12787499, 16321950, 17981983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 10049369, 12787499, 16321950, 17981983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine phosphoribosylpyrophosphate amidotransferase" /protein_id="NP_388531.2" /db_xref="EnsemblGenomes-Gn:BSU06490" /db_xref="EnsemblGenomes-Tr:CAB12469" /db_xref="GOA:P00497" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005854" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR035584" /db_xref="PDB:1AO0" /db_xref="PDB:1GPH" /db_xref="SubtiList:BG10707" /db_xref="UniProtKB/Swiss-Prot:P00497" /translation="MLAEIKGLNEECGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGI VATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFRS QNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKN SLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLR EVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKM LAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQ GVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHP CFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLA CFTGKYPTEIYQDTVLPHVKEAVLTK*" /label="purF CDS" gene 607603..609033 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /label="purF gene" S_feature 609034..609134 /Source="Nicolas_S_feature" /locus_tag="new_706872_706972" /HighExp="MG 15, MG 25, MG 10, MG 5, aero, S0, MG t5, Gly, LPh, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S232" CDS 609135..610175 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /EC_number="6.3.3.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10508786, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole synthetase" /protein_id="NP_388532.2" /db_xref="EnsemblGenomes-Gn:BSU06500" /db_xref="EnsemblGenomes-Tr:CAB12470" /db_xref="GOA:P12043" /db_xref="InterPro:IPR004733" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10708" /db_xref="UniProtKB/Swiss-Prot:P12043" /translation="MSEAYKNAGVDIEAGYEAVKRMKKHVERTKRLGVMGSLGGFGGM FDLSELSYQKPVLISGTDGVGTKLKLAFSMDKHDTIGVDAVAMCVNDVLAQGAEPLFF LDYLAVGKADPVKIEQIVQGVAEGCEQSGSALVGGETAEMPGLYTADEYDIAGFSVGV AEKDEIVTGEKIEEGHLLIGLSSSGLHSNGFSLVRKVLLDDAELDLDTTYEPFERPLG EELLEPTRIYVKPVLAAVKSGKIDGMAHVTGGGFIENIPRMLPEGLSAEIDHGSWPIP PIFSFLQEYGKLKEEDMFNVFNMGIGFVLAVKEEHLTDVIGTLESHGEKAYLIGRVKK GEGVTFGGAALS*" /label="purM CDS" gene 609135..610175 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /label="purM gene" CDS 610172..610759 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /EC_number="2.1.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10569930, 12787499, 19574646; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase" /protein_id="NP_388533.2" /db_xref="EnsemblGenomes-Gn:BSU06510" /db_xref="EnsemblGenomes-Tr:CAB12471" /db_xref="GOA:P12040" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR004607" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG10709" /db_xref="UniProtKB/Swiss-Prot:P12040" /translation="MKKFAVFASGNGSNFEAIVTRLKEENWDASAALLVCDKPQAKVI ERAEAFHIPSFAFEPKSYENKAAFEQAIIEQLRLHEVELIALAGYMRLIGDTLLQAYG GKIINIHPSLLPAFPGIDAVGQAFRAGVKVAGITVHYVDEGMDTGPIIAQKAIEIDEH DTLETIEQRIHKLEHKWYPSVIKQLLGLNNRGEKA*" /label="purN CDS" gene 610172..610759 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /label="purN gene" misc_feature 610182..610196 /Source="Nicolas_upshift_promotors" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 610191 /Source="Nicolas_upshifts" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(610458..610476) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(610465) /Source="Nicolas_upshifts" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(610492..610497) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 610756..612294 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /EC_number="2.1.2.3" /EC_number="3.5.4.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787499, 1937050, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase" /protein_id="NP_388534.2" /db_xref="EnsemblGenomes-Gn:BSU06520" /db_xref="EnsemblGenomes-Tr:CAB12472" /db_xref="GOA:P12048" /db_xref="InterPro:IPR002695" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024051" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10710" /db_xref="UniProtKB/Swiss-Prot:P12048" /translation="MTIKRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQENG VDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVN LYPFKETISKEDVTYEEAIENIDIGGPGMLRAASKNHQDVTVIVDPADYSPVLNQIKE EGSVSLQKKRELAAKVFRHTAAYDALIADYLTNVVGEKEPEQFTVTFEKKQSLRYGEN PHQEATFYQTALPVKGSIAQAEQLHGKELSYNNIKDADAAVQIVREFTEPAAVAVKHM NPCGVGTGKTIAEAFDRAFEADKTSIFGGIIALNREVDKATAEALHNIFLEIIIAPSF SQEALDVLTAKKNLRLLTLDVSAAVQKEKQLTSVQGGLLIQDLDMHGFDDAEISIPTK REPNEQEWEDLKLAWKVVKHVKSNAIVLAKDNMTVGVGAGQMNRVGSAKIAIEQAGEK AKGSALGSDAYFPMPDTVEEAAKAGVTAIIQPGGSIRDEDSIKKADEYGIAMVFTGIR HFKH*" /label="purH CDS" gene 610756..612294 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /label="purH gene" CDS 612310..613578 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /EC_number="6.3.4.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 12787499, 16321950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide synthetase" /protein_id="NP_388535.1" /db_xref="EnsemblGenomes-Gn:BSU06530" /db_xref="EnsemblGenomes-Tr:CAB12473" /db_xref="GOA:P12039" /db_xref="InterPro:IPR000115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR020559" /db_xref="InterPro:IPR020560" /db_xref="InterPro:IPR020561" /db_xref="InterPro:IPR020562" /db_xref="InterPro:IPR037123" /db_xref="PDB:2XCL" /db_xref="PDB:2XD4" /db_xref="SubtiList:BG10711" /db_xref="UniProtKB/Swiss-Prot:P12039" /translation="MNVLIIGKGGREHTLAWKAAQSSLVENVFAAPGNDGMAASAQLV NIEESDHAGLVSFAKQNQVGLTIVGPEVPLIEGLVDEFEKAGLHVFGPSKAAAIIEGS KQFAKDLMKKYDIPTAEYETFTSFDEAKAYVQEKGAPIVIKADGLAAGKGVTVAMTEE EAIACLHDFLEDEKFGDASASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFD GDKGPNTGGMGAYSPVPQISEETVRHAVETIVKPAAKAMVQEGRSFTGVLYAGLMLTE NGSKVIEFNARFGDPETQVVLPRMESDLVQVLLDLLDDKEVDLRWKDTAAVSVVLASE GYPESYAKGTPIGSLAAETEQVVVFHAGTKAEGGEFVTNGGRVANVTAFDETFEAARD RVYKAVDEIFKPGLFFRKDIGARALKAAQK*" /label="purD CDS" gene 612310..613578 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /label="purD gene" downshifts 613563 /Source="Nicolas_upshifts" /id="D320" /incds=0 /nref=140 /ntot=249 /MaxReadThrough="2.77191" /MaxDrop="5.90939" /score="30.0999687" /energy="-11.4" /TU="NA" /idTUdmin="U500" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(613618..614037) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388536.2" /db_xref="EnsemblGenomes-Gn:BSU06540" /db_xref="EnsemblGenomes-Tr:CAB12474" /db_xref="GOA:O31497" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12874" /db_xref="UniProtKB/Swiss-Prot:O31497" /translation="MDDTDLQILSHLQRNGRLTMVELGKLVGLSSPSAAERVRKLEDK GVITGYSANICYEKLNKHVTAFILMEPKSCKHYAAFATSHPDVAENHRITGMYSYVTK VVTESVHTLEDFIDTSMAHGKPTTLVVLSSSSCHPAF*" /label="yezC CDS" gene complement(613618..614037) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /label="yezC gene" misc_feature complement(614107..614126) /Source="Nicolas_upshift_promotors" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(614116) /Source="Nicolas_upshifts" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="upshifts" CDS 614181..615455 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26319875, 27723097, 24678831; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_388537.2" /db_xref="EnsemblGenomes-Gn:BSU06550" /db_xref="EnsemblGenomes-Tr:CAB12475" /db_xref="GOA:O34560" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12817" /db_xref="UniProtKB/Swiss-Prot:O34560" /translation="MLPELQRSITWIQGTALTIGAVLGCGILILPSVTADTAGPASLF VWVFMSFLSFFLVGTLARLVKIAPSAGGITAYVQLAFQKKAGAILGWIMLGSVPIGVP IIALTGAHYVSYITEAADWQITLIAGCMLAISILLHMRGIQLSANISTLVICVIVFLL VTSIAVSLPHVTIAEFKPFLPHGWSAAGSVSVMIFFSFVGWEMITPLAEEFHRPEKDV PLSLFLAASCVAGLYIMLSFVTVGTHSYGENGEIASLAMLISKGAGESGVYVTVCLAL FITFATIHANIAGFSRMVYALAREGHIPVFFGKLSATKRTPIRVLTAMAAVFGLVLAA HGLFQIDLTTLLKGPSAAFIASYICTMAAALKLLGRRDIGWWMALGAFVACAVIYSFS GWALLYPAVLAAAGYFYMKTKGGHKKKLDHVL*" /label="yecA CDS" gene 614181..615455 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /label="yecA gene" downshifts 615404 /Source="Nicolas_upshifts" /id="D321" /incds=0 /nref=4 /ntot=64 /MaxReadThrough="0.796809999999999" /MaxDrop="2.92696" /score="1.68718502" /energy="-14.2" /TU="NA" /idTUdmin="U498" /TUdmin=1825 /isTUend="FALSE" /label="downshifts" CDS complement(615470..615697) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097691.1" /db_xref="EnsemblGenomes-Gn:BSU06559" /db_xref="EnsemblGenomes-Tr:CAX52578" /db_xref="GOA:C0H3X3" /db_xref="InterPro:IPR021309" /db_xref="UniProtKB/Swiss-Prot:C0H3X3" /translation="MKPNISLINAVFRIACGLTIMSAASAKFTKKPWCRMHLFYIFMG AMKAGSGILRFCPVTYMFQHSDSGNNEHQNG*" /label="yezF CDS" gene complement(615470..615697) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /label="yezF gene" downshifts complement(615481) /Source="Nicolas_upshifts" /id="D322" /incds=0 /nref=29 /ntot=46 /MaxReadThrough="0.14199" /MaxDrop="6.82335" /score="34.1397958" /energy="-13.9" /TU="NA" /idTUdmin="U504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(615698..616118) /Source="Nicolas_S_feature" /locus_tag="new_713536_713956_c" /HighExp="S8, S7, S5, S6, S4, ferm, nit, BT, Pyr, T5.0H" /AntisenseName="yerA" /AntisenseCor="0.38264258041500998" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S233" promotor_-35 615765..615770 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 615781 /Source="Nicolas_upshifts" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 615784..615803 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 615826..617568 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23109554; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenine deaminase YerA" /protein_id="NP_388538.1" /db_xref="EnsemblGenomes-Gn:BSU06560" /db_xref="EnsemblGenomes-Tr:CAB12476" /db_xref="GOA:O34909" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG12829" /db_xref="UniProtKB/Swiss-Prot:O34909" /translation="MSERTFNWKNKDIRAQVDVVDSKLLPTLLLRNALVLNPYVKQWL KKNIWIYQDRIVYVGHELPNRAEEIHTIDCEGKYIVPGYIEPHAHPFQIYNPQTLAEY VSQYGTTTFVNDNLFLLLQSGKKKALTILNELKKQPVQYFWWSRYDLQTEVLNEDHVL PFDVRKQWIEHPDVIQGGEMTGWPRLVDGDDLMLHCMQATKKQRKRIEGHFPGASDKT LTKMKLFGADCDHEAMTGDEVMRRLELGYYVSLRNSSIRPDVRKILQELHEKGFRYYD HFFYTTDGATPNFYKGGMTNELIRIALEEGVPAIDAYNMASFNIAKYYQMDDYLGVVG PGRLASLNILEDPLNPNPVTVLSKGTILRENGCDLKAFTKTDWHKGGLVPLELSYDMT MDDLQFSMPMGVKMRNAVIMEPYMIEIDNSMEQLSFDHDESYLTMLDRHGKWRVNTMI KGFASSVQGFVSSFTTTGDIVAIGKNKADMLLAFARMKEIGGGIVLAENGNILHEIPL ALCGCASSEAYEDVLEKEQKLRDLLTERGYEFCDPIYTLLFLQSTHLPYIRITPRGIF DVMKKTVLFPSIMR*" /label="yerA CDS" gene 615826..617568 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /label="yerA gene" promotor_-10 complement(616103..616114) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(616118) /Source="Nicolas_upshifts" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(616128..616134) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 616149 /Source="Nicolas_upshifts" /id="D323" /incds=1 /nref=13 /ntot=109 /MaxReadThrough="7.92321" /MaxDrop="3.44855" /score="1.68718502" /energy="-14.2" /TU="U503" /idTUdmin="U498" /TUdmin=2570 /isTUend="FALSE" /label="downshifts" promotor_-35 617542..617548 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 617560 /Source="Nicolas_upshifts" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 617561..617580 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 617595..618590 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12073041; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388539.1" /db_xref="EnsemblGenomes-Gn:BSU06570" /db_xref="EnsemblGenomes-Tr:CAB12477" /db_xref="GOA:O34968" /db_xref="InterPro:IPR021416" /db_xref="InterPro:IPR023158" /db_xref="InterPro:IPR035328" /db_xref="PDB:2PSB" /db_xref="SubtiList:BG12830" /db_xref="UniProtKB/Swiss-Prot:O34968" /translation="MKKWMTVCALCFVFFLLVSCQQKDAVPDTAKKLKAPLTGLKTEQ KVTERRPVAVVVNNHPKARPQSGLSKADIVIEALAEGQITRFLAIFQSQMPETVGPVR SAREYFVTLSNGFDSIFVHHGWSPGAKKQLESGAADYMNGLDFDGSLFWRADFSKPPH NSYTSYDYIKKAAEQKGYKLKQETNPLLFQTSDAKPANESYNVRVDYGTNNVTNLVEY NYDKKAEFYTRSSDGVITTDRETGKPVAMQNIFIVEASHHIIDQDGRRDIDLESGGKG LLFQHGNVIETDWKQVNGRIVPVKDGKWLPFVPGKTWINIVPDLDAASISKGEGV*" /label="yerB CDS" gene 617595..618590 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /label="yerB gene" CDS 618593..618907 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor-histidine operons" /protein_id="NP_388540.1" /db_xref="EnsemblGenomes-Gn:BSU06580" /db_xref="EnsemblGenomes-Tr:CAB12478" /db_xref="GOA:Q7BVT7" /db_xref="InterPro:IPR000831" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013368" /db_xref="SubtiList:BG12831" /db_xref="UniProtKB/Swiss-Prot:Q7BVT7" /translation="MQIDKLRGKELDQLFNSILSLKDLEECYRFFDDLCTINEIQSLA QRLEVARMLREGNTYHKIETETGASTATISRVKRCLNYGNDAYEMALDRVKETETESS SK*" /label="yerC CDS" gene 618593..618907 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /label="yerC gene" downshifts 618770 /Source="Nicolas_upshifts" /id="D324" /incds=1 /nref=1 /ntot=25 /MaxReadThrough="7.1005" /MaxDrop="2.3494" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" downshifts 618912 /Source="Nicolas_upshifts" /id="D325" /incds=0 /nref=78 /ntot=262 /MaxReadThrough="3.58776" /MaxDrop="5.59364" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-232" /isTUend="FALSE" /label="downshifts" CDS complement(618942..620519) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /EC_number="1.4.1.13" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15805528, 17114254, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative osmotic shock glutamate synthase subunit (flavoprotein subunit, ferredoxin-dependent)" /protein_id="NP_388541.1" /db_xref="EnsemblGenomes-Gn:BSU06590" /db_xref="EnsemblGenomes-Tr:CAB12479" /db_xref="GOA:O34849" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024188" /db_xref="InterPro:IPR027283" /db_xref="SubtiList:BG12832" /db_xref="UniProtKB/Swiss-Prot:O34849" /translation="METIIIALIAFIIGIIAIPIVLFAWIYIKDEKQQEHSILRNYPV IGRFRYILEKIGPELRQYLYSNDNEEQPFSRKEYEQTVISGKYKSRMMGFGSVRDFDK PGYYIRNAMFPKQREEMHVNQTPKIETQIYKMDADNLFKRKEHAEHIKADPYFLHPDD VQVIGEHTCEKPFYVKGLVGQSAMSYGSLGERAVTALSKGLHLAGGTWMNTGEGGLSE YHLKGGADIICQIGPGLFGVRKRNGEFSWEEFKRKSRIDQIKAFELKLAQGAKTRGGH VDGAKVSEEVADIRNVEPGKSIDSPNRFYEFSNPPEMLDFIEKLRDVGQKPVGIKLVA GHPEELHELFSHMQKSGKHPDFITIDGSEGGTGASFYELADTVGLPIMTALPIVDTLL KQYGLRSQLKIFASGKLLTPDKIAVALALGADFVNIARGMMFSVGCIRALVCHTNTCP AGVATTDPKLQKALSVEEKQHRVCNYVISLREGLFNLAAAAGINSPIHFSKEHVVYRK EDGSIINIDNLIHQFVS*" /label="yerD CDS" gene complement(618942..620519) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /label="yerD gene" downshifts complement(618956) /Source="Nicolas_upshifts" /id="D326" /incds=0 /nref=7 /ntot=24 /MaxReadThrough="2.99325" /MaxDrop="5.6389" /score="34.8793815" /energy="-15.8" /TU="U506" /idTUdmin="U506" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(620533..620552) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(620552) /Source="Nicolas_upshifts" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(620567..620573) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 620716..620719 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 620733 /Source="Nicolas_upshifts" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 620736..620755 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 620784..621470 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16377641, 21761520, 21214173, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16377641, 21761520, 21214173, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heptaprenylglyceryl-phosphate synthase" /protein_id="NP_388542.1" /db_xref="EnsemblGenomes-Gn:BSU06600" /db_xref="EnsemblGenomes-Tr:CAB12480" /db_xref="GOA:O34790" /db_xref="InterPro:IPR008205" /db_xref="PDB:1VIZ" /db_xref="PDB:3VZX" /db_xref="PDB:3VZY" /db_xref="PDB:3VZZ" /db_xref="PDB:3W00" /db_xref="SubtiList:BG12833" /db_xref="UniProtKB/Swiss-Prot:O34790" /translation="MYDVTEWKHVFKLDPNKDLPDEQLEILCESGTDAVIIGGSDGVT EDNVLRMMSKVRRFLVPCVLEVSAIEAIVPGFDLYFIPSVLNSKNADWIVGMHQKAMK EYGELMSMEEIVAEGYCIANPDCKAAALTEADADLNMDDIVAYARVSELLQLPIFYLE YSGVLGDIEAVKKTKAVLETSTLFYGGGIKDAETAKQYAEHADVIVVGNAVYEDFDRA LKTVAAVKGE*" /label="pcrB CDS" gene 620784..621470 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /label="pcrB gene" CDS 621532..623751 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 12682299, 14594837, 16267290, 26070154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_388543.1" /db_xref="EnsemblGenomes-Gn:BSU06610" /db_xref="EnsemblGenomes-Tr:CAB12481" /db_xref="GOA:O34580" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR005751" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG12834" /db_xref="UniProtKB/Swiss-Prot:O34580" /translation="MNYISNQLLSGLNPVQQEAVKTTDGPLLLMAGAGSGKTRVLTHR IAYLMAEKHVAPWNILAITFTNKAAREMKERVESILGPGADDIWISTFHSMCVRILRR DIDRIGINRNFSILDTADQLSVIKGILKERNLDPKKFDPRSILGTISSAKNELTEPEE FSKVAGGYYDQVVSDVYADYQKKLLKNQSLDFDDLIMTTIKLFDRVPEVLEFYQRKFQ YIHVDEYQDTNRAQYMLVKQLAERFQNLCVVGDSDQSIYRWRGADITNILSFEKDYPN ASVILLEQNYRSTKRILRAANEVIKNNSNRKPKNLWTENDEGIKISYYRGDNEFGEGQ FVAGKIHQLHSTGKRKLSDIAILYRTNAQSRVIEETLLKAGLNYNIVGGTKFYDRKEI KDILAYLRLVSNPDDDISFTRIVNVPKRGVGATSLEKIASYAAINGLSFFQAIQQVDF IGVSAKAANALDSFRQMIENLTNMQDYLSITELTEEILDKTEYREMLKAEKSIEAQSR LENIDEFLSVTKNFEQKSEDKTLVAFLTDLALIADIDQLDQKEEESGGKDAITLMTLH AAKGLEFPVVFLMGLEEGVFPHSRSLMEEAEMEEERRLAYVGITRAEQELYLTNAKMR TLFGRTNMNPESRFIAEIPDDLLENLNEKKETRATSARKMQPRRGPVSRPVSYASKTG GDTLNWAVGDKAGHKKWGTGTVVSVKGEGEGTELDIAFPSPVGVKRLLAAFAPIEKQ* " /label="pcrA CDS" gene 621532..623751 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /label="pcrA gene" CDS 623775..625781 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /EC_number="6.5.1.2" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:164915, 11095673, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 164915, 11095673, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ligase (NAD-dependent)" /protein_id="NP_388544.1" /db_xref="EnsemblGenomes-Gn:BSU06620" /db_xref="EnsemblGenomes-Tr:CAB12482" /db_xref="GOA:O31498" /db_xref="InterPro:IPR001357" /db_xref="InterPro:IPR001679" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004149" /db_xref="InterPro:IPR004150" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013839" /db_xref="InterPro:IPR013840" /db_xref="InterPro:IPR018239" /db_xref="InterPro:IPR033136" /db_xref="InterPro:IPR036420" /db_xref="SubtiList:BG12835" /db_xref="UniProtKB/Swiss-Prot:O31498" /translation="MDKETAKQRAEELRRTINKYSYEYYTLDEPSVPDAEYDRLMQEL IAIEEEHPDLRTPDSPTQRVGGAVLEAFQKVTHGTPMLSLGNAFNADDLRDFDRRVRQ SVGDDVAYNVELKIDGLAVSLRYEDGYFVRGATRGDGTTGEDITENLKTIRNIPLKMN RELSIEVRGEAYMPKRSFEALNEERIKNEEEPFANPRNAAAGSLRQLDPKIAAKRNLD IFVYSIAELDEMGVETQSQGLDFLDELGFKTNQERKKCGSIEEVITLIDELQAKRADL PYEIDGIVIKVDSLDQQEELGFTAKSPRWAIAYKFPAEEVVTKLLDIELNVGRTGVIT PTAILEPVKVAGTTVSRASLHNEDLIKEKDIRILDKVVVKKAGDIIPEVVNVLVDQRT GEEKEFSMPTECPECGSELVRIEGEVALRCINPECPAQIREGLIHFVSRNAMNIDGLG ERVITQLFEENLVRNVADLYKLTKERVIQLERMGEKSTENLISSIQKSKENSLERLLF GLGIRFIGSKAAKTLAMHFESLENLKKASKEELLAVDEIGEKMADAVITYFHKEEMLE LLNELQELGVNTLYKGPKKVKAEDSDSYFAGKTIVLTGKLEELSRNEAKAQIEALGGK LTGSVSKNTDLVIAGEAAGSKLTKAQELNIEVWNEEQLMGELKK*" /label="ligA CDS" gene 623775..625781 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /label="ligA gene" CDS 625797..626987 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388545.1" /db_xref="EnsemblGenomes-Gn:BSU06630" /db_xref="EnsemblGenomes-Tr:CAB12483" /db_xref="GOA:O34629" /db_xref="InterPro:IPR011426" /db_xref="SubtiList:BG12836" /db_xref="UniProtKB/Swiss-Prot:O34629" /translation="MKKTLALAATAAVLMLSACSSGFGGEKEEEITQKTAKSSEKAIV PKYNISDSYYKMVLPFKAGKARGLTTEQLNTRLDIDEFETGLMRLAQDSFSTDDYLFQ EGQYLDEDTVLSWLARKKTGSDLKKAEKEDKNFKNEGLNPALPSSGSTEEKNESSPIY LASMLEHDYLVRKDKNSIQLGGVMIGLALNSVYYYREKTGDPQKEVEIKDSTLRQQGE KIAQEVINRLRKKDNLKNVPITVALYKQASKTSIVPGNFIAKTEVKAGSTDISNWDDI NEKYVFYPADTTTAEKYPDDTEVFKRFKNSIEEYFPNYTGVVGTALYENDEMKKMKID IPMQFYGKSEVVAFTQFLTGEVMDYYSKSSVDVEVNITSSDGQEAVIIRNAGDKEPTV HIYD*" /label="yerH CDS" gene 625797..626987 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /label="yerH gene" misc_feature complement(625992..625996) /Source="Nicolas_upshift_promotors" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(625996) /Source="Nicolas_upshifts" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 627024..627043 /Source="Nicolas_upshift_promotors" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 627032..627148 /Source="Nicolas_S_feature" /locus_tag="new_724870_724986" /HighExp="LoTm, B60, Lbstat, B36, BI, M9-stat, T1.30H, ferm, T3.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S234" upshifts 627032 /Source="Nicolas_upshifts" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(627096) /Source="Nicolas_upshifts" /id="D327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="1.21197" /MaxDrop="3.77048" /score="18.5253059" /energy="-17.7" /TU="NA" /idTUdmin="U511" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" CDS 627149..628159 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase" /protein_id="NP_388546.1" /db_xref="EnsemblGenomes-Gn:BSU06640" /db_xref="EnsemblGenomes-Tr:CAB12484" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG12837" /db_xref="UniProtKB/Swiss-Prot:O34640" /translation="MLDVHKDIKKIFHEEQVLAEAAARYGFSKDQVRFLADAENYVYE CMKDNQPYILKITHTIRRSSDYMMGEMEWLRHLAIGGISVAKPLPSLNGKDVEAVPDG NGGSFLLRVYEKAPGQKVDESDWNETLFYELGRYTGSMHSLTKSYKLSNPAFKRQEWD EEEQLKLRKYVPEDQIKVFQQADSLMNELRRLPKSQDNYGLVHADLHHGNFNWDHGKI TAFDFDDIGYNWFVNDISILLYNVLWYPVVPYDDKAAFTEEFMTHFMKGYWEENELDP AWLMIIPDFLRLRHMLIYGLLHQMFDLNTIGEEEKEMLAGFRRDIENGTPITAFDFSA LV*" /label="yerI CDS" gene 627149..628159 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /label="yerI gene" promotor_no_box complement(627166..627266) /Source="Nicolas_upshift_promotors" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(627206) /Source="Nicolas_upshifts" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 628142 /Source="Nicolas_upshifts" /id="D328" /incds=0 /nref=137 /ntot=253 /MaxReadThrough="3.07041" /MaxDrop="5.10987" /score="12.7441524" /energy="-17" /TU="NA" /idTUdmin="U507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 628186..628990 /Source="Nicolas_S_feature" /locus_tag="new_726024_726828" /HighExp="B60, B36, LoTm, M9-stat, Cold, T1.30H, T0.30H, ferm, Lbstat, LBGstat" /AntisenseName="sapB" /AntisenseCor="-0.57665624439942198" /AntisenseRegPval="-24.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S235" CDS complement(628197..628895) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 410907, 9043134, 14708580, 27350030, 28181542; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative magnesium transporter" /protein_id="NP_388547.1" /db_xref="EnsemblGenomes-Gn:BSU06650" /db_xref="EnsemblGenomes-Tr:CAB12485" /db_xref="GOA:Q45514" /db_xref="InterPro:IPR003416" /db_xref="SubtiList:BG11845" /db_xref="UniProtKB/Swiss-Prot:Q45514" /translation="MLLSWYIDPDILLKLGIATLIGMVIGLERELKNKPLGLKTCIVI AVSSCMLTIVSINAAYHFPKYYRIMMDPLRLPAQIISGVGFIGAGVILRKSNDVISGL TTSAMIWGAAGLGLATGAGFYKEAFASLLFILISVEFLPWVVRKIGPDRLQEKDIRIR MSLSDKDKMTEILKEMKRRDIKAHSVRIDDLGEKDFPIMEVKVRVHKNRYTTDVYYDI KAIEGVVGVKCDTL*" /label="sapB CDS" gene complement(628197..628895) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /label="sapB gene" downshifts complement(628218) /Source="Nicolas_upshifts" /id="D329" /incds=0 /nref=26 /ntot=129 /MaxReadThrough="2.5379" /MaxDrop="3.83708" /score="20.8493264" /energy="-16.2" /TU="NA" /idTUdmin="U511" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(628915..628933) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(628936) /Source="Nicolas_upshifts" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(628949..628954) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(629002..630480) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline transporter" /protein_id="NP_388548.1" /db_xref="EnsemblGenomes-Gn:BSU06660" /db_xref="EnsemblGenomes-Tr:CAB12486" /db_xref="GOA:O06493" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12641" /db_xref="UniProtKB/Swiss-Prot:O06493" /translation="MSIEIIISLGIYFIAMLLIGWYAFKKTTDINDYMLGGRGLGPFV TALSAGAADMSGWMLMGVPGAMFATGLSTLWLALGLTIGAYSNYLLLAPRLRAYTEAA DDAITIPDFFDKRFQHSSSLLKIVSALIIMIFFTLYTSSGMVSGGRLFESAFGADYKL GLFLTTAVVVLYTLFGGFLAVSLTDFVQGAIMFAALVLVPIVAFTHVGGVAPTFHEID AVNPHLLDIFKGASVISIISYLAWGLGYYGQPHIIVRFMAIKDIKDLKPARRIGMSWM IITVLGSVLTGLIGVAYAHKFGVAVKDPEMIFIIFSKILFHPLITGFLLSAILAAIMS SISSQLLVTASAVTEDLYRSFFRRKASDKELVMIGRLSVLVIAVIAVLLSLNPNSTIL DLVGYAWAGFGSAFGPAILLSLYWKRMNEWGALAAMIVGAATVLIWITTGLAKSTGVY EIIPGFILSMIAGIIVSMITKRPAKASYRLFGVMEKLLKRKK*" /label="opuE CDS" gene complement(629002..630480) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /label="opuE gene" downshifts complement(629016) /Source="Nicolas_upshifts" /id="D330" /incds=0 /nref=43 /ntot=142 /MaxReadThrough="5.35634" /MaxDrop="4.34381" /score="9.43100511" /energy="-13.8" /TU="U512,U513" /idTUdmin="U511" /TUdmin="-798" /isTUend="FALSE" /label="downshifts" upshifts complement(629868) /Source="Nicolas_upshifts" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(629871..629884) /Source="Nicolas_upshift_promotors" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(630481..630611) /Source="Nicolas_S_feature" /locus_tag="new_728319_728449_c" /HighExp="Salt, HiOs, Etha, Gly, MG 25, MG 45, M9-exp, MG t5, MG 15, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.954" /TUlongSig="NA" /TUlongPSig="NA" /label="S236" promotor_-10 complement(630602..630620) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(630611) /Source="Nicolas_upshifts" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(630635..630641) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 630742..630745 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 630760..630893 /Source="Nicolas_S_feature" /locus_tag="new_728598_728731" /HighExp="G180, G150, LBGexp, Oxctl, Paraq, dia0, G135, Lbexp, H2O2, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S237" upshifts 630760 /Source="Nicolas_upshifts" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 630762..630781 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 630894..631184 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9342321, 11445070, 12682299, 25005615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9342321, 11445070, 12682299, 25005615; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit C)" /protein_id="NP_388549.1" /db_xref="EnsemblGenomes-Gn:BSU06670" /db_xref="EnsemblGenomes-Tr:CAB12487" /db_xref="GOA:O06492" /db_xref="InterPro:IPR003837" /db_xref="InterPro:IPR036113" /db_xref="SubtiList:BG12838" /db_xref="UniProtKB/Swiss-Prot:O06492" /translation="MSRISIEEVKHVAHLARLAITEEEAKMFTEQLDSIISFAEELNE VNTDNVEPTTHVLKMKNVMREDEAGKGLPVEDVMKNAPDHKDGYIRVPSILD*" /label="gatC CDS" gene 630894..631184 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /label="gatC gene" CDS 631200..632657 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit A)" /protein_id="NP_388550.1" /db_xref="EnsemblGenomes-Gn:BSU06680" /db_xref="EnsemblGenomes-Tr:CAB12488" /db_xref="GOA:O06491" /db_xref="InterPro:IPR000120" /db_xref="InterPro:IPR004412" /db_xref="InterPro:IPR020556" /db_xref="InterPro:IPR023631" /db_xref="InterPro:IPR036928" /db_xref="SubtiList:BG12839" /db_xref="UniProtKB/Swiss-Prot:O06491" /translation="MSLFDHKITELKQLIHKKEIKISDLVDESYKRIQAVDDKVQAFL ALDEERARAYAKELDEAVDGRSEHGLLFGMPIGVKDNIVTKGLRTTCSSKILENFDPI YDATVVQRLQDAEAVTIGKLNMDEFAMGSSTENSAYKLTKNPWNLDTVPGGSSGGSAA AVAAGEVPFSLGSDTGGSIRQPASFCGVVGLKPTYGRVSRYGLVAFASSLDQIGPITR TVEDNAFLLQAISGVDKMDSTSANVDVPDFLSSLTGDIKGLKIAVPKEYLGEGVGKEA RESVLAALKVLEGLGATWEEVSLPHSKYALATYYLLSSSEASANLARFDGIRYGYRTD NADNLIDLYKQTRAEGFGNEVKRRIMLGTFALSSGYYDAYYKKAQKVRTLIKKDFEDV FEKYDVIVGPTTPTPAFKIGENTKDPLTMYANDILTIPVNLAGVPGISVPCGLADGLP LGLQIIGKHFDESTVYRVAHAFEQATDHHKAKPEL*" /label="gatA CDS" gene 631200..632657 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /label="gatA gene" CDS 632671..634101 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit B)" /protein_id="NP_388551.2" /db_xref="EnsemblGenomes-Gn:BSU06690" /db_xref="EnsemblGenomes-Tr:CAB12489" /db_xref="GOA:O30509" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR004413" /db_xref="InterPro:IPR006075" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR017958" /db_xref="InterPro:IPR017959" /db_xref="InterPro:IPR018027" /db_xref="InterPro:IPR023168" /db_xref="SubtiList:BG12840" /db_xref="UniProtKB/Swiss-Prot:O30509" /translation="MNFETVIGLEVHVELKTKSKIFSSSPTPFGAEANTQTSVIDLGY PGVLPVLNKEAVEFAMKAAMALNCEIATDTKFDRKNYFYPDNPKAYQISQFDKPIGEN GWIEIEVGGKTKRIGITRLHLEEDAGKLTHTGDGYSLVDFNRQGTPLVEIVSEPDIRT PEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPIGQEEFGTKTELKNLNSF AFVQKGLEHEEKRQEQVLLSGGVIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDL VELYIDDEWKERVKASIPELPDERRKRYIEELGLPAYDAMVLTLTKEMADFFEETVQK GAEAKQASNWLMGEVSAYLNAEQKELADVALTPEGLAGMIKLIEKGTISSKIAKKVFK ELIEKGGDAEKIVKEKGLVQISDEGVLLKLVTEALDNNPQSIEDFKNGKDRAIGFLVG QIMKASKGQANPPMVNKILLEEIKKR*" /label="gatB CDS" gene 632671..634101 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /label="gatB gene" downshifts 634082 /Source="Nicolas_upshifts" /id="D331" /incds=0 /nref=257 /ntot=266 /MaxReadThrough="1.62334" /MaxDrop="8.77378" /score="26.1218607" /energy="-9.6" /TU="NA" /idTUdmin="U514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(634116..634985) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388552.1" /db_xref="EnsemblGenomes-Gn:BSU06700" /db_xref="EnsemblGenomes-Tr:CAB12490" /db_xref="GOA:O31500" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG12841" /db_xref="UniProtKB/Swiss-Prot:O31500" /translation="MNEKKERIIKTSIRLFAKKGFAATTIQEIASECGISKGAFYLHF KSKEALLLSACEYYIGMSMNKMKNIEEDLAGKPPKEVLKKQIGAQFEDFRDHKDFIVL LLTENIIPENQEIKQYFYKVTMETDKLYRNALLVSYGEGIERYVADLSIMARGIVHSY MNVMVFNGELNIDAEEISAFIIERLDDLVQGLSRSALNPIVSKDIFNPMPAGKDQLLE DIQKVKENSTLPEDITVSLDVIEEELTQDKPRKPIIKGMLSNLAGTNDKEVERLRALI LSLSQFDHKKSSL*" /label="yerO CDS" gene complement(634116..634985) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /label="yerO gene" downshifts complement(634158) /Source="Nicolas_upshifts" /id="D332" /incds=0 /nref=122 /ntot=211 /MaxReadThrough="2.21801" /MaxDrop="4.89305" /score="32.2694333" /energy="-11.4" /TU="NA" /idTUdmin="U517" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 634775..634780 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-35" promotor_-10 634796..634814 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-10" upshifts 634808 /Source="Nicolas_upshifts" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="upshifts" S_feature complement(634986..635060) /Source="Nicolas_S_feature" /locus_tag="new_732824_732898_c" /HighExp="C30, S1, T3.0H, T4.0H, Salt, T5.0H, T2.0H, T3.30H, MG 150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S238" promotor_-35 635038..635045 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(635054..635073) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 635060 /Source="Nicolas_upshifts" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 635061..635080 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(635067) /Source="Nicolas_upshifts" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(635088..635095) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-35" CDS 635117..638275 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11709341, 15066026, 15941986, 25366377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11709341, 15066026, 15941986, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter involved in surfactin self-resistance" /protein_id="NP_388553.2" /db_xref="EnsemblGenomes-Gn:BSU06710" /db_xref="EnsemblGenomes-Tr:CAB12491" /db_xref="GOA:O31501" /db_xref="InterPro:IPR001036" /db_xref="InterPro:IPR027463" /db_xref="SubtiList:BG12842" /db_xref="UniProtKB/Swiss-Prot:O31501" /translation="MNHVINFVLKNKFAVWLMTIIVTAAGLYAGMNMKQESIPDVNMP YLTISTTYPGATPSQVADEVTKPVEQAVQNLDGVSVVTSTSYENASSVMIEYDYEKDM DKAKTEAAEALENVNLPDDAKDPEISRYSLNSFPILTLSVSSDKDNLQELTKQVEDSL VSKLEGIEGVASVQVSGQQVEEVEFSFKEDKLKEYGLDEDTVKQVIQGSDVTTPLGLY TFGNEEKSVVVSGDIETIKDLKNMRIPTASASSAGSSAASQAGAQSAQAAQSAQAAAQ VQQSASTAVPTVKLSDIATIKDVKKAESVSRTNGKDSIGINIVKANDANTVEVADDVK AELKKFKEDHKGFNYSATLDMAEPITQSVDTMLSKAIFGAIFAIVIILLFLRDIKSTL ISVVSIPLSLLIALLVLQQLDITLNIMTLGAMTVAIGRVVDDSIVVIENIYRRMRLKD EPLRGKALVREATKEMFKPIMSSTIVTIAVFLPLALVGGQIGELFIPFALTIVFALAA SLVISITLVPMLAHSLFKKSLTGAPIKAKEHKPGRLANIYKKVLNWALSHKWITSIIA VLMLLGSLFLVPLIGASYLPSEEEKTMQLTYSPEPGETKKEAENEAEKAEKILLDRKH VDTVQYSLGSGSPLAGGDSNGALFYIKYESDTPDFDKEKDNVLKEIQKQSDRGEWKSQ DFSSSGNNNELTYYVYGDSENDIKDTVKDIEKIMKDEKDLKNVNSGLSSTYDEYTFVA DQEKLSKLGLTASQISQALMSQTSQEPLTTVKKDGKELDVNIKTEKDEYKSVKDLENK KITSATGQEVKIGDVAKVKEGSTSDTVSKRDGKVYADVTGEVTSDNVTAVSAAIQKKI DKLDHPDNVSIDTGGVSADIADSFTKLGLAMLAAIAIVYLVLVITFGGALAPFAILFS LPFTVIGALVGLYVSGETISLNAMIGMLMLIGIVVTNAIVLIDRVIHKEAEGLSTREA LLEAGSTRLRPILMTAIATIGALIPLALGFEGGSQVISKGLGVTVIGGLISSTLLTLL IVPIVYEVLAKFRKKKPGTEEE*" /label="srfP CDS" gene 635117..638275 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /label="srfP gene" downshifts 638262 /Source="Nicolas_upshifts" /id="D333" /incds=0 /nref=76 /ntot=243 /MaxReadThrough="3.70478" /MaxDrop="4.6624" /score="-3.65521193" /energy="-12.7" /TU="U516" /idTUdmin="U516" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 638514..638517 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 638532..638551 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 638540 /Source="Nicolas_upshifts" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="upshifts" CDS 638598..639509 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /EC_number="2.7.1.107" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12682299, 17535816, 22224599, 24700682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12682299, 17535816, 22224599, 24700682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diacylglycerol kinase" /protein_id="NP_388554.1" /db_xref="EnsemblGenomes-Gn:BSU06720" /db_xref="EnsemblGenomes-Tr:CAB12492" /db_xref="GOA:O31502" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG12843" /db_xref="UniProtKB/Swiss-Prot:O31502" /translation="MKRARIIYNPTSGREIFKKHLAQVLQKFEQAGYETSTHATTCAG DATHAAKEAALREFDLIIAAGGDGTINEVVNGLAPLDNRPTLGVIPVGTTNDFARALG IPREDILKAADTVINGVARPIDIGQVNGQYFINIAGGGRLTELTYDVPSKLKTMLGQL AYYLKGMEMLPSLRPTEVEIEYDGKLFQGEIMLFLVTLTNSVGGFEKLAPDSSLNDGM FDLMILKKANLAEFIRVATMALRGEHINDQHIIYTKANRVKVNVSEKMQLNLDGEYGG MLPGEFVNLYRHIHVVMPKEKAEQLDD*" /label="dagK CDS" gene 638598..639509 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /label="dagK gene" S_feature 639510..639764 /Source="Nicolas_S_feature" /locus_tag="new_737348_737602" /HighExp="H2O2, Oxctl, Paraq, G180, Cold, C30, G150, G135, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S239" CDS 639765..641144 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /EC_number="2.1.1.189" /EC_number="2.1.1.190" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21824914" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21824914; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyltransferase of m5U747 and m5U1939 in 23S RNA" /protein_id="NP_388555.1" /db_xref="EnsemblGenomes-Gn:BSU06730" /db_xref="EnsemblGenomes-Tr:CAB12493" /db_xref="GOA:O31503" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12826" /db_xref="UniProtKB/Swiss-Prot:O31503" /translation="MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEE KAQIKVTRVKKGFAFGRLIELKEESPHRTDAPCPIYKQCGGCQLQHMTYEGQLLFKQK QVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAGFYQQRSHDI IDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIV FITRTSDFPHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLI GDVKFAISARSFYQVNPEQTKVLYDKALEYAELQGEETVIDAYCGIGTISLFLAKQAK KVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWYEEGITADTLVVDPPRK GCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVE CCVLIKLKE*" /label="rlmCD CDS" gene 639765..641144 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /label="rlmCD gene" S_feature 641145..641737 /Source="Nicolas_S_feature" /locus_tag="new_738983_739575" /HighExp="Cold, H2O2, G135, G150, Oxctl, G180, C30, Paraq, LPh, HPh" /AntisenseName="yefB" /AntisenseCor="0.24913678485492899" /AntisenseRegPval="-4.4000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S240" CDS complement(641157..642059) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1779754, 1762151; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase / invertase; HGT island" /protein_id="NP_388556.1" /db_xref="EnsemblGenomes-Gn:BSU06740" /db_xref="EnsemblGenomes-Tr:CAB12494" /db_xref="GOA:O34574" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="SubtiList:BG12827" /db_xref="UniProtKB/Swiss-Prot:O34574" /translation="MYNEGVTSPSQLARKKNATDKWHGSSIRKILENPHYTGTLQQCR EYRPSVTSKRRRSVNLENQIIIEKSHEPIIPLEDFLIVQEILITRKRRRPQAEVHLFT NTAVCKDCRRSMHFKKNRKGYVCGSYNKHGLKACSDHYVSEIDLTDKVITNLNKIYLK FSKENYFKELSEKALKYKEKIESKIIEINEKLNDKKRDKSNLVISLANGVISKEDYQL AINITNEDISNFETTLHQLSKDLEFQKIEKEIIDFKKSLDKFMKEGTLTPEMLHLLVD EIEVHANGTIEINYRFREPTVPSA*" /label="yefB CDS" gene complement(641157..642059) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /label="yefB gene" downshifts 641694 /Source="Nicolas_upshifts" /id="D334" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="4.70474" /MaxDrop="2.82299" /score="-8.81916201" /energy="-8.8" /TU="U518" /idTUdmin="U516" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 641739..642039 /Source="Nicolas_S_feature" /locus_tag="new_739577_739877" /HighExp="H2O2, Cold, G180, G135, G150, Paraq, Oxctl, C30, LPh, LBGexp" /AntisenseName="yefB" /AntisenseCor="0.202214664414261" /AntisenseRegPval="-3.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S241" CDS 642040..642375 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative resolvase; HGT island" /protein_id="NP_388557.2" /db_xref="EnsemblGenomes-Gn:BSU06750" /db_xref="EnsemblGenomes-Tr:CAB12495" /db_xref="GOA:O35034" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG12828" /db_xref="UniProtKB/Swiss-Prot:O35034" /translation="MTPSLYNPLAIASKPFPAIYSEKILIFTIFSAFAEFERDMIVER TQEGKMLAKQNPDFREGRPKKFTKQQINHALTLLENHSYKQVEDMTGISVSTLVRAKK KKAAEAING*" /label="yefC CDS" gene 642040..642375 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /label="yefC gene" S_feature 642376..642449 /Source="Nicolas_S_feature" /locus_tag="new_740214_740287" /HighExp="G180, H2O2, G150, Cold, G135, Paraq, Oxctl, C30, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S242" CDS 642450..645089 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative restriction type II methylase; HGT island" /protein_id="NP_388558.1" /db_xref="EnsemblGenomes-Gn:BSU06760" /db_xref="EnsemblGenomes-Tr:CAB12496" /db_xref="GOA:O31504" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12818" /db_xref="UniProtKB/Swiss-Prot:O31504" /translation="MALIDLEDKIAEIVNREDHSDFLYELLGVYDVPRATITRLKKGN QNLTKRVGEVHLKNKVWFKEAKKGKLFDALIDIEQQVEYLSAKPRYLLVTDYDGVLAK DTKTLEALDVKFEELPQYFDFFLAWKGIEKVEFEKENPADIKAAERFARIYDVLRKEN NIIETNRGLDLFLIRLLFCFFAEDTDIFKRNSFTNLIKTLTEEDGSNLNKLFADLFIV LDKNERDDVPSYLKEFPYVNGQLFTEPHTELEFSAKSRKLIIECGELLNWAKINPDIF GSMIQAVASEESRSYLGMHYTSVPNIMKVIKPLFLDKLNQSFLDAYDDYTKLENLLTR IGKIKFFDPACGSGNFLIITYKELRRMEINIIKRLQELLGEYLYVPSVTLSQFYGIEI EDFAHDVAKLSLWIAEHQMNEELKNEVHNAVRPTLPLHTAGDIRCANAIRVEWTEVCP AQGSEEVYVFGNPPYLGSKKQNKEHKSDMLSIFGKVKNGKMLDYISAWFYFGAKYAST TNAKVAFVSTNSVTQGEQVSILWNELFKFGIQINFAYKSFKWANNAKNNAAVIVVIVG FGPLDTKVNKYLFVDETKKLVSNISPYLTDGENILVSSRTKPISDLPKLHFGNMPNDG GGLLFTITEYTDAINKYPELVPYFKKFIGSVEFINGGLRYCLWLNEAKYEKIKSNPLI QERISISKNHREKSTDKGTNKLALTPWKFRDTHETTNYSIVVPSVSSENRFYIPMGLA GADTILSNLIYVIYDAEIYLLGILMSRMHMTWVKAVAGRLKTDYRYSAGLCYNTFPIP ELSTRRKNEIEEAILEILDLREEQGGTLAELYNPSTMPIELKVAHEKLDGIVERAYRQ KQFESDEERLEVLLKLYQEMTER*" /label="yeeA CDS" gene 642450..645089 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /label="yeeA gene" CDS 645101..646900 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA helicase / endonuclease; HGT island" /protein_id="NP_388559.2" /db_xref="EnsemblGenomes-Gn:BSU06770" /db_xref="EnsemblGenomes-Tr:CAB12497" /db_xref="GOA:O34469" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12819" /db_xref="UniProtKB/Swiss-Prot:O34469" /translation="MENIIEINYNQTGKSKKTNEYGMREMQARAFEKRNSQYLLVKAP PASGKSRALMFIGLDKLINQGLRKVIVAVPERSIGSSFKNTDLKSYGFFENWKVDPRN NLTVGGDNSKVKSFVRFMESDDQVLICTHSTLRFAFEKIDDKAFDNCLLAIDEFHHVS ADVNSRLGELLRSIIHNSSAHIVAMTGSYFRGDSVPILLPEDEELFDKVTYSYYEQLD GYEYLKGFGIGYHFYQGQYTSAINEVLDTNKKTIVHIPNVNSGESTKDKYDEVGKILD MIGEVEYQDDDTGIIYVKRHSDGKTLKIADLVDDQVGRENVVAYLRNIEALDDLDIII ALGMAKEGFDWPFCEHTLTVGYRGSLTEIVQIIGRCTRDSYNKTYAQFTNLIAMPDAK DEVVTYTVNTMLKAISASLLMEQVLTPDFKFKRRRNESEKSSTTGELFVKGLKEPSTE NVKKIIENDINDLKAKIMQDSQVQKTFSGEVDPKVLNKVLIPKVIQKVYPNLSDEEIE EVRQHVVLDTVMKGAKSEVVGSKEFIRMADKFINIEDLDINLIDSINPFQKAFEVLSK ELNSPVLKLIQETIDAKRINFDEDELVFIWPKV*" /label="yeeB CDS" gene 645101..646900 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /label="yeeB gene" promotor_-10 complement(645341..645356) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(645356) /Source="Nicolas_upshifts" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(645368..645377) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 646901..647012 /Source="Nicolas_S_feature" /locus_tag="new_744739_744850" /HighExp="Cold, G180, G135, G150, H2O2, Paraq, HPh, LPh, Oxctl, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S243" CDS 647013..648161 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388560.2" /db_xref="EnsemblGenomes-Gn:BSU06780" /db_xref="EnsemblGenomes-Tr:CAB12498" /db_xref="InterPro:IPR018306" /db_xref="SubtiList:BG12820" /db_xref="UniProtKB/Swiss-Prot:O34352" /translation="MASNRYHSINEIMESQLFYQITTPPKKTQKAQYDPEVEKFLEII EFVKENGREPQKVPTDLTERSLASRLIGIRKDPDRMEYLKEYDEIGLLEVRSKELTIP KISSIDDILKSGLSALLGDNLNNDITRSIFDTSSLQKVTTMPEYVAKRKKIKDFGKFE ELFKKCHKEITEGKRKILTFKNEQDIQSNSFYILKGVLLYVEDVGERKKAKGKTNARL RCIFENGTESDMLLRSLSAELYKHGRRVTDNEDTLLDNVREDDVSTGFIYVLKSLSTD PQISSIKNLYKIGFTTGSVENRIRNAENQSTYLYAPVEIVTTYQVFNMNASKFETAIH HALANNNLDVSILGANGKMLVPKEWFVVTLEDLQAVIDEIVMMVHLYD*" /label="yeeC CDS" gene 647013..648161 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /label="yeeC gene" S_feature 648162..649351 /Source="Nicolas_S_feature" /locus_tag="new_746000_747189" /HighExp="Cold, G135, H2O2, G180, G150, LPh, C30, HPh, BMM, Paraq" /AntisenseName="yeeD" /AntisenseCor="-0.41772847620445203" /AntisenseRegPval="-12.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S244" CDS complement(648423..648728) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388561.1" /db_xref="EnsemblGenomes-Gn:BSU06790" /db_xref="EnsemblGenomes-Tr:CAB12499" /db_xref="SubtiList:BG12821" /db_xref="UniProtKB/Swiss-Prot:O34950" /translation="MTVRKELIKQINLTITVIKTINQKNPTPMVKNILKRYEEAKEFI LQSSDGKFEEDLSKVRNKLDTLTRAYLESANDYMNPMLKEMHKTEKLLKEYDETTQS* " /label="yeeD CDS" gene complement(648423..648728) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /label="yeeD gene" CDS complement(648795..649001) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="hypothetical protein; HGT island" /protein_id="NP_388562.1" /db_xref="EnsemblGenomes-Gn:BSU06800" /db_xref="EnsemblGenomes-Tr:CAB12500" /db_xref="GOA:O31505" /db_xref="InterPro:IPR000290" /db_xref="InterPro:IPR035900" /db_xref="SubtiList:BG12872" /db_xref="UniProtKB/Swiss-Prot:O31505" /translation="MDKLTKEELIFLVKELMNPTLDDEKVSEYLDLLEKNVPYPAPSD LIFWSNEDYTAEQVVKIALNYKDE*" /label="yezA CDS" gene complement(648795..649001) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /label="yezA gene" CDS complement(649241..649696) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="YP_003097692.1" /db_xref="EnsemblGenomes-Gn:BSU06811" /db_xref="EnsemblGenomes-Tr:CAX52579" /db_xref="InterPro:IPR006728" /db_xref="InterPro:IPR036170" /db_xref="UniProtKB/Swiss-Prot:C0H3X4" /translation="MQDLYQLIGEKLNDIIPGEWTKIYLYAEVLDDSTMVLFHFRTPE NNQIIYSQDIPSHYNVSKDIFKTLLRELRELFEELRTEHRNNNDDVWTNLTLTLDRSG EFQLDYNYDDILASELDGYERIAIWEYKNLGILPEDEDDKEFVISYLGL*" /label="yezG CDS" gene complement(649241..649696) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /label="yezG gene" downshifts complement(649254) /Source="Nicolas_upshifts" /id="D335" /incds=0 /nref=41 /ntot=213 /MaxReadThrough="4.42275" /MaxDrop="5.23695" /score="10.2582155" /energy="-11.7" /TU="U520,U521" /idTUdmin="U520" /TUdmin="-529" /isTUend="FALSE" /label="downshifts" CDS complement(649716..651725) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein; HGT island" /protein_id="NP_388563.2" /db_xref="EnsemblGenomes-Gn:BSU06812" /db_xref="EnsemblGenomes-Tr:CAB12501" /db_xref="GOA:O31506" /db_xref="InterPro:IPR006829" /db_xref="SubtiList:BG12822" /db_xref="UniProtKB/Swiss-Prot:O31506" /translation="MKVFEAKTLLSEATDRAKEYKELRTQMVNLRKALKGVADLSDSE FSGKGASNIKAFYHDHVGVADQWIDYIDMKIAFFNSIAGAAEDKGLSDAYIEESFLEH ELANANKKSKSIMSEQKKAMKDILNDIDDILPLDLFSTETFKDELADANDKRKKTLEK LDALDEDLKTEYALSEPNEQFIKSDFQKLQEATGKGKNATPIHYNAKAYRESDIHKKK GDIEKRTEAYLKIKKEEAKEREIEKLKERLKNYDYADADEFYEMAKTIGYENLTAEQQ RYFTQIENTRELEAGFKGVAVGLYDSGKDAVVGLWDMVTDPGGTVEAITGAMAHPIKT YEAISAAIEESYQKDMVNGDTYSRARWVSYAVGTVVTSIVGTKGVGAVSKTGTAAKVT TKVKTAASKSATAQKAITVSKQTVDHIKQKVNTGIEVSKKHVKTKLNQIGDLTLADIL PYHPRHDLVPAGVPYNAVNGVTLKEGLQKFAKVILPKPYGTSSSGRRTPAPHVPPVTV KYGEHFARWSRKKVLKPNIIYKTKEGYTYTTDNYGRITSVKADLQLGEAKRNQYAQTN AGKPQDRKPDDDGGHLIATQFKGSGQFDNIVPMNSQINRSGGKWYEMEQEWAKALSKK PPKKVAVQIEPVYSGDSLRPSYFDVTYKIGSRKEISVSIKNQPGG*" /label="yeeF CDS" gene complement(649716..651725) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /label="yeeF gene" promotor_-10 complement(650083..650102) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(650090) /Source="Nicolas_upshifts" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(650115..650120) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(651752..651771) /Source="Nicolas_upshift_promotors" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(651762) /Source="Nicolas_upshifts" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="upshifts" CDS 651937..652959 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage receptor protein" /protein_id="NP_388564.2" /db_xref="EnsemblGenomes-Gn:BSU06820" /db_xref="EnsemblGenomes-Tr:CAB12502" /db_xref="GOA:O31507" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12823" /db_xref="UniProtKB/Swiss-Prot:O31507" /translation="MTKKRITFGLLVLMVCVILFVLYVQLRNKDSIPVQSSAIHPEED RIFFIYSNPFIKESVLLSTSTGERFNRRTFKVADVPYIQTKSYASTDLVLLAEHEPFY YTLEKDVIKEHPLSDPFAFWYEGKDVTIEAYNVDTTGNEIHINDRKTKKEYTLTLPPL VTMGASDENFIYIIQSMSIYVIDRKTEEMIETLSLASYADQFADSEEFIVASSDHKLT VIEKGTWKTTYIAYPEDLEYADTVYYDKESGSFYVAYEDKEGGANLLEYGEDFSIHTY SLKFPYMEAKFKGNLLYIVAQEEHKKGIGGYVGVFDIHSKEMLYQFDLPEEQVKVQDF VVVDNK*" /label="yeeG CDS" gene 651937..652959 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /label="yeeG gene" promotor_-35 653059..653066 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-35" promotor_-10 653080..653099 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-10" upshifts 653081 /Source="Nicolas_upshifts" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="upshifts" CDS 653121..654251 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388565.2" /db_xref="EnsemblGenomes-Gn:BSU06830" /db_xref="EnsemblGenomes-Tr:CAB12503" /db_xref="GOA:Q59HN8" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG11031" /db_xref="UniProtKB/Swiss-Prot:Q59HN8" /translation="MSQAIPSSRVGVKINEWYKMIRQFSVPDAEILKAEVEQDIQQME EDQDLLIYYSLMCFRHQLMLDYLEPGKTYGNRPTVTELLETIETPQKKLTGLLKYYSL FFRGMYEFDQKEYVEAIGYYREAEKELPFVSDDIEKAEFHFKVAEAYYHMKQTHVSMY HILQALDIYQNHPLYSIRTIQSLFVIAGNYDDFKHYDKALPHLEAALELAMDIQNDRF IAISLLNIANSYDRSGDDQMAVEHFQKAAKVSREKVPDLLPKVLFGLSWTLCKAGQTQ KAFQFIEEGLDHITARSHKFYKELFLFLQAVYKETVDERKIHDLLSYFEKKNLHAYIE ACARSAAAVFESSCHFEQAAAFYRKVLKAQEDILKGECLYAY*" /label="rapH CDS" gene 653121..654251 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /label="rapH gene" CDS 654241..654414 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type r: regulator" /codon_start=1 /transl_table=11 /product="hexapeptide (TDRNTT) inhibitor of regulatory cascade" /protein_id="YP_003097693.1" /db_xref="EnsemblGenomes-Gn:BSU06839" /db_xref="EnsemblGenomes-Tr:CAX52580" /db_xref="GOA:Q59HN7" /db_xref="UniProtKB/Swiss-Prot:Q59HN7" /translation="MPIKKKVMMCLAVTLVFGSMSFPTLTNSGGFKESTDRNTTYIDH SPYKLSDQKKALS*" /label="phrH CDS" gene 654241..654414 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /label="phrH gene" downshifts 654369 /Source="Nicolas_upshifts" /id="D336" /incds=0 /nref=3 /ntot=66 /MaxReadThrough="5.5891" /MaxDrop="2.9063" /score="14.5772672" /energy="-7.6" /TU="U522" /idTUdmin="U522" /TUdmin="-901" /isTUend="FALSE" /label="downshifts" S_feature 654415..654519 /Source="Nicolas_S_feature" /locus_tag="new_752253_752357" /HighExp="S2, G/S, T2.30H, GM 150, T3.0H, T2.0H, S1, T-4.40H, T-2.40H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S245" promotor_-35 654486..654493 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 654508..654527 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 654521 /Source="Nicolas_upshifts" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="upshifts" CDS 654574..655293 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA integrase or transcriptional regulator" /protein_id="NP_388566.3" /db_xref="EnsemblGenomes-Gn:BSU06840" /db_xref="EnsemblGenomes-Tr:CAB12504" /db_xref="GOA:O31509" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026562" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG12824" /db_xref="UniProtKB/Swiss-Prot:O31509" /translation="MGRKWNNIKEKKASKDANTSRIYAKFGREIYVAAKQGEPDPESN QALKVVLERAKTYSVPKNIIERAIEKAKGGAEENYDELRYEGFGPNGSMIIVDALTNN VNRTAPEVRAAFGKNGGNMGVSGSVAYMFDATAVIGVEGKTADEALEILMEADVDVRD ILEEDDSAIVYAEPDQFHAVQEAFKNAGVEEFTVAELTMLAQSEVTLPDDAKEQFEKL IDALEDLEDVQQVYHNVDLGE*" /label="yeeI CDS" gene 654574..655293 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /label="yeeI gene" downshifts complement(654576) /Source="Nicolas_upshifts" /id="D337" /incds=0 /nref=3 /ntot=70 /MaxReadThrough="1.42969" /MaxDrop="3.99424" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-5851" /isTUend="FALSE" /label="downshifts" promotor_-35 655151..655158 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 655172..655191 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 655182 /Source="Nicolas_upshifts" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" downshifts 655275 /Source="Nicolas_upshifts" /id="D338" /incds=0 /nref=223 /ntot=271 /MaxReadThrough="4.94236" /MaxDrop="5.19148" /score="31.0415099" /energy="-11.4" /TU="U523,U524" /idTUdmin="U522" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 655362..655371 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 655385..655404 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 655388 /Source="Nicolas_upshifts" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(655392..655410) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(655412) /Source="Nicolas_upshifts" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(655426..655431) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 655427..655864 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 19060142, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 19060142, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore inner coat protein" /protein_id="NP_388567.2" /db_xref="EnsemblGenomes-Gn:BSU06850" /db_xref="EnsemblGenomes-Tr:CAB12505" /db_xref="GOA:O31510" /db_xref="SubtiList:BG12825" /db_xref="UniProtKB/Swiss-Prot:O31510" /translation="MTDTRHMYGGPGFGHYQGFGIGHPGYGMQSTGYPGYGMYGGHPG YGMQGYPDHGIHGGVGGYPGYGGYGGYPSGGYGGSPGTGSYPSMHHENDGHHHYYHHH HDGKDNLHHHHHHVGKDNHHHHHDGHYGHHHHHMGHWGKDGYK*" /label="cotK CDS" gene 655427..655864 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /label="cotK gene" downshifts complement(655434) /Source="Nicolas_upshifts" /id="D339" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.62645" /MaxDrop="3.26146" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-6709" /isTUend="FALSE" /label="downshifts" downshifts 655864 /Source="Nicolas_upshifts" /id="D340" /incds=0 /nref=82 /ntot=208 /MaxReadThrough="2.37564" /MaxDrop="8.21113" /score="17.7046271" /energy="-9" /TU="U525" /idTUdmin="U523" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 655924..655931 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 655947..655966 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 655952 /Source="Nicolas_upshifts" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="upshifts" CDS 655979..656563 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR family)" /protein_id="YP_054572.1" /db_xref="EnsemblGenomes-Gn:BSU06860" /db_xref="EnsemblGenomes-Tr:CAE01448" /db_xref="GOA:Q7WY76" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14194" /db_xref="UniProtKB/Swiss-Prot:Q7WY76" /translation="MGRNKEFDTALVLHRAIEVFGEYGYEGTSLQDLLSHLGIARQSL YDTYGTKRDLFLSAVKSYLEGKNAAVMERLEAPGSVKEAIRDIFQEGVNALRDPERAK ACYIINSAIEQIPHDPELARYFERQSKQLEDAFYHGLLRAKDQGELNGEDTDISALAR YLNQSRLSLTFIAKVTADMDRLQDHVDVSLSVLD*" /label="yezE CDS" gene 655979..656563 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /label="yezE gene" downshifts 656544 /Source="Nicolas_upshifts" /id="D341" /incds=0 /nref=26 /ntot=216 /MaxReadThrough="2.43615" /MaxDrop="3.31193" /score="17.7046271" /energy="-9" /TU="NA" /idTUdmin="U527" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 656642..657085 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388568.1" /db_xref="EnsemblGenomes-Gn:BSU06870" /db_xref="EnsemblGenomes-Tr:CAB12506" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:1S5A" /db_xref="SubtiList:BG12844" /db_xref="UniProtKB/Swiss-Prot:O31511" /translation="MLMNEFEKACETLRKFMAYMLEKDMKSWTELWDENAVFEFPYAP EGSPKRIEGKAAIYDYIKDYPKQIHLSSFTAPTVYRSADSNTVIAEFQCDGHVIETGL PYRQSYISVIETRDGRIVRYRDYWNPLVVKEAFGGSFLQTEESGK*" /label="yesE CDS" gene 656642..657085 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /label="yesE gene" CDS 657082..657942 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21494745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388569.1" /db_xref="EnsemblGenomes-Gn:BSU06880" /db_xref="EnsemblGenomes-Tr:CAB12507" /db_xref="GOA:O31512" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR008030" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11808" /db_xref="UniProtKB/Swiss-Prot:O31512" /translation="MMKQNPILITGGTGTVGSRIASRLIKLGYRVRIASRKKGALADA EYVYFNWKYASSFTPALEQVKQIYLVAPVGVFDPAPYVLPFLKEAKRLGAKRVVMQSA SVVSENGPVFGALHQAVREFPEWTVLRPSYFMQNFINVQHRMSIQTEGRITTASGEGK LGFIDADDIAETAVRALIDDVPHQTHHILTGPEALSYAEAAEIIGAAAGRRVEHVSIS RSELQHKMEAGGLPADYAHFMAKLDEAISHGAEHRVTDTVKRVTGKEPRSLSEFAAAH AAYWTSFWTE*" /label="yesF CDS" gene 657082..657942 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /label="yesF gene" promotor_-35 658004..658009 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 658025..658043 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 658025 /Source="Nicolas_upshifts" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(658047..658061) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(658052) /Source="Nicolas_upshifts" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(658069..658073) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 658069..658317 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388570.1" /db_xref="EnsemblGenomes-Gn:BSU06890" /db_xref="EnsemblGenomes-Tr:CAB12508" /db_xref="InterPro:IPR020256" /db_xref="SubtiList:BG11799" /db_xref="UniProtKB/Swiss-Prot:Q45536" /translation="MKDMQPFTPVKSYTPFHSRFDPCPPIGKKYYRTPPNLYMTFQPE HMEQFSPMEALRKGTLWKDLYDFYENPYRGGDAHGKKG*" /label="cotJA CDS" gene 658069..658317 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /label="cotJA gene" CDS 658301..658564 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388571.2" /db_xref="EnsemblGenomes-Gn:BSU06900" /db_xref="EnsemblGenomes-Tr:CAB12509" /db_xref="InterPro:IPR016571" /db_xref="InterPro:IPR024207" /db_xref="SubtiList:BG11800" /db_xref="UniProtKB/Swiss-Prot:Q45537" /translation="MAKKVDAEYYRQLEQIQAADFVLVELSLYLNTHPHDEDALKQFN QYSGYSRHLKRQFESSYGPLLQFGNSPAGKDWDWGKGPWPWQV*" /label="cotJB CDS" gene 658301..658564 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /label="cotJB gene" CDS 658579..659148 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /EC_number="1.11.1.6" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7768848, 9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7768848, 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="enzyme component of the inner spore coat" /protein_id="NP_388572.1" /db_xref="EnsemblGenomes-Gn:BSU06910" /db_xref="EnsemblGenomes-Tr:CAB12510" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG11801" /db_xref="UniProtKB/Swiss-Prot:Q45538" /translation="MWVYEKKLQYPVKVSTCNPTLAKYLIEQYGGADGELAAALRYLN QRYTIPDKVIGLLTDIGTEEFAHLEMIATMVYKLTKDATPEQLREAGLGDHYVNHDSA LFYHNAAGVPFTASYIQAKGDPIADLYEDIAAEEKARATYQWLIDISDDPDLNDSLRF LREREIVHSMRFREAVEILKEERDKKKIF*" /label="cotJC CDS" gene 658579..659148 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /label="cotJC gene" S_feature 659149..659227 /Source="Nicolas_S_feature" /locus_tag="new_756987_757065" /HighExp="S4, S5, S3, S7, S6, B36, LoTm, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S246" promotor_-35 659200..659205 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 659220..659239 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 659229 /Source="Nicolas_upshifts" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="upshifts" CDS 659273..659815 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388573.1" /db_xref="EnsemblGenomes-Gn:BSU06920" /db_xref="EnsemblGenomes-Tr:CAB12511" /db_xref="GOA:O31513" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11809" /db_xref="UniProtKB/Swiss-Prot:O31513" /translation="MTAFKIENETIADGFYACPAVYEDAESITGLLVRTAEWLRDRGS NQWSGLLKGQDIHDITGSIEKGHVFVFKKDEELAAVVMLLPAPSEWDRTLWGDDGHEE SIYLHRLAVSRRFAGQGLGARVLQWAETGIHFPEKTRIRLDCVADSDALHSFYRRMGY EFMGADASGYHLFEKEITAE*" /label="yesJ CDS" gene 659273..659815 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /label="yesJ gene" downshifts 659782 /Source="Nicolas_upshifts" /id="D342" /incds=0 /nref=104 /ntot=251 /MaxReadThrough="3.04389" /MaxDrop="4.5316" /score="8.56782582" /energy="-5.8" /TU="U528" /idTUdmin="U530" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS 659838..660140 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388574.2" /db_xref="EnsemblGenomes-Gn:BSU06930" /db_xref="EnsemblGenomes-Tr:CAB12512" /db_xref="GOA:O31514" /db_xref="InterPro:IPR025434" /db_xref="SubtiList:BG12845" /db_xref="UniProtKB/Swiss-Prot:O31514" /translation="MSFSKREAGDVWSILFVTGIVTACLFAGVSVLMRMRFPDKSRPE WMLAGLIVLGVFAIWYSLVYVRGWEGAALGMLGFNVIFGAIAGYLIDKAIRRYRKR*" /label="yesK CDS" gene 659838..660140 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /label="yesK gene" promotor_-35 660183..660191 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 660202..660220 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 660208 /Source="Nicolas_upshifts" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="upshifts" CDS 660255..660884 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25441682; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease or sensor of a three componentsystem for pectin and rhamnogalacturonan transport anddegradation" /protein_id="NP_388575.1" /db_xref="EnsemblGenomes-Gn:BSU06940" /db_xref="EnsemblGenomes-Tr:CAB12513" /db_xref="GOA:O31515" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12846" /db_xref="UniProtKB/Swiss-Prot:O31515" /translation="MLMIHSVANGLNHFCTWVMRLAYLNVLWILFSLAGLVVFGLMPA TAAMFTVAREWAKGNTDAPVFSVFFRTFKKEWRASQILGLIVVTAALFLFADMRIAAQ MDQPVLVNVFVSISLIFAFVVLYVFPVFSHFDVKIREVLSISFFIAFSRPAVTLLMAA GAVGVLCLVLFHVTFLLFFSGSLLSLILTKLSFKAFRSMDQRQEKEKAA*" /label="yesL CDS" gene 660255..660884 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /label="yesL gene" CDS 660881..662614 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 23436677, 25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 23436677, 25441682; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YesN]" /protein_id="NP_388576.1" /db_xref="EnsemblGenomes-Gn:BSU06950" /db_xref="EnsemblGenomes-Tr:CAB12514" /db_xref="GOA:O31516" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12847" /db_xref="UniProtKB/Swiss-Prot:O31516" /translation="MKKRVAGWYRRMKIKDKLFVFLSLIMAVSFLFVYSGVQYAFHVY DEQIYRKSSEVLRMSSERIEDELKKIEDVSYEIITDEQIQRILSMQNRDDTYDQYQMK QELWDQLAGYASDEKYIDSIHVIDARGSEYSAGSSSSDLLQQEQEEVFKRAKAKSGRN LWMTLGGSDPVLISARQIRSYHQLSLNGLGMVLIQVNVKQMIRDVPKDWGDSVGDIMI ADQGGNLVYTAHASAHVPEAAKETLKHPGYDLIKKNGKRYFISYLQSSYQNWSYYNVI PFDQMFAKISFMKTVIGTCFLLFFCVVLLFGRKIANSITEPIEQLVTAMKSVQHSGIE AGVSLSLPEHTQDEAGMLNRHFTVMMKRINELMEENVEKQLIIKETELKALQAQINPH FLYNTLESINWLAKANQQKQISKMVESLGFLLRNSIHMKKDIVTIQEEADIVRHYMTI QRFRFEERLKFTLDIDDEVKHCLIPKLTLQPLAENAIQYALEPFTRPCAIRIQAKKAK GCVCITVEDNGPGMDGRILESTGGRGIGLWNIRERISLTFGEPYGLRIHSEHEKGTRI VITIPCRNEVV*" /label="yesM CDS" gene 660881..662614 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /label="yesM gene" CDS 662614..663720 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25441682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YesM]" /protein_id="NP_388577.1" /db_xref="EnsemblGenomes-Gn:BSU06960" /db_xref="EnsemblGenomes-Tr:CAB12515" /db_xref="GOA:O31517" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12848" /db_xref="UniProtKB/Swiss-Prot:O31517" /translation="MYKILLADDERIILDGMAGIIEWESLGASLIGKAQNGHEAYEKI VHKQPHIVITDVKMPGMDGLELIKKVSAVSPSVQFIVLSGFGEFEYAKEAMKYGVKHY LLKPCNEQQIISSLEEIIAELKRQDVHKKKTAHLKHELDHIRSFAADQYLEGLIAGVA QLSPPPSLAGKKIRLLILKGEQSIDAAAREALGSALTAVCSSGEWTVLAVEENAAEKV AEVFADRKMAISQAGELRHAGQLFRDTAEASGDLHGSAVISKMIRLIADELGNPNLSL KWAAKDMLFMNPDYLGKLFKQETGEKFSQYVTRVRLEHAMKQMKIRRDVSVSEIAEEI GFGDNPKYFSLVFKKYTGLTPSEFRRKQGGASAG*" /label="yesN CDS" gene 662614..663720 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /label="yesN gene" downshifts 663674 /Source="Nicolas_upshifts" /id="D343" /incds=0 /nref=4 /ntot=43 /MaxReadThrough="0.271749999999999" /MaxDrop="3.41261" /score="3.12085441" /energy="-10.3" /TU="NA" /idTUdmin="U531" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" promotor_-35 663759..663762 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 663777..663796 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 663784 /Source="Nicolas_upshifts" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 663824..665107 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 25658435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 25658435; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="pectin degradation byproducts (rhamnose oligosaccharides)-binding lipoprotein" /protein_id="NP_388578.2" /db_xref="EnsemblGenomes-Gn:BSU06970" /db_xref="EnsemblGenomes-Tr:CAB12516" /db_xref="PDB:4R6K" /db_xref="SubtiList:BG12849" /db_xref="UniProtKB/Swiss-Prot:O31518" /translation="MKKICYVLLSLVCVFLFSGCSAGEEASGKKEDVTLRIAWWGGQP RHDYTTKVIELYEKKNPHVHIEAEFANWDDYWKKLAPMSAAGQLPDVIQMDTAYLAQY GKKNQLEDLTPYTKDGTIDVSSIDENMLSGGKIDNKLYGFTLGVNVLSVIANEDLLKK AGVSINQENWTWEDYEKLAYDLQEKAGVYGSNGMHPPDIFFPYYLRTKGERFYKEDGT GLAYQDDQLFVDYFERQLRLVKAKTSPTPDESAQIKGMEDDFIVKGKSAITWNYSNQY LGFARLTDSPLSLYLPPEQMQEKALTLKPSMLFSIPKSSEHKKEAAKFINFFVNNEEA NQLIKGERGVPVSDKVADAIKPKLNEEETNIVEYVETASKNISKADPPEPVGSAEVIK LLKDTSDQILYQKVSPEKAAKTFRKKANEILERNN*" /label="yesO CDS" gene 663824..665107 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /label="yesO gene" CDS 665104..666033 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388579.1" /db_xref="EnsemblGenomes-Gn:BSU06980" /db_xref="EnsemblGenomes-Tr:CAB12517" /db_xref="GOA:O31519" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12850" /db_xref="UniProtKB/Swiss-Prot:O31519" /translation="MTGNGADAMKKSRSIRKDNLAGYAFISPFIIGFLCFTVIPMGAS LFLSFTSYDLFTAPKWIGLDNFKEMFTGDEKYWQSLKVTFTYVLAGVPLRLGFALFIA VILNNAAKGTAIYRTLFYLPSIIGGSVAVAIMWRNIFGNDGVINALLFFVGIDQKILW YQNPTSALWTLILLSVWQFGSSMLIFLAGLKNIPSSYLEAASVDGANRVQRFFKITLP ILTPIIFFNLVMQTISAFMTFTPAYIISKGEGGPLDGTLLYSLYLFQRAFNYFQMGYA SAMAWVMLVIVGLITLILFKTSSYWVHYESKEE*" /label="rhgP CDS" gene 665104..666033 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /label="rhgP gene" CDS 666037..666927 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388580.1" /db_xref="EnsemblGenomes-Gn:BSU06990" /db_xref="EnsemblGenomes-Tr:CAB12518" /db_xref="GOA:O31520" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12851" /db_xref="UniProtKB/Swiss-Prot:O31520" /translation="MEPVNQPVREAPVFERKKAGRVSPKRILFHVFTATLAVLLLYPV IWLFVSSFKESASIFTTSHSLIPDPFILSNYAEGWKGIAGQPFLTFIKNSAIIVGLST IGAVMSSAVIAYGFARIPFKGKKFWFACMMGTLMLPHEVLMIPQYIMFAKLDWLNSFK PIVVPQFFGHAFFIFLMIQFIRTIPEELDEAARIDGCGRFACFWRIILPLIAPALATS AIFSFYWKWEELIQPLLYLNKPELYPVSLALKLFLDTESASNWGAMFAMSAVSLLPVI LVFFLFQKYIVQGISTTGLK*" /label="rhgQ CDS" gene 666037..666927 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /label="rhgQ gene" CDS 666943..667977 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /EC_number="3.2.1.172" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan hydrolase" /protein_id="NP_388581.1" /db_xref="EnsemblGenomes-Gn:BSU07000" /db_xref="EnsemblGenomes-Tr:CAB12519" /db_xref="GOA:O31521" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="SubtiList:BG12852" /db_xref="UniProtKB/Swiss-Prot:O31521" /translation="MAQLIFDEEKVTSVIDRIVKRTFQMDFAWDWPGGVAFYGVAEAY EATENEEYINLLKTWVDEQLEDGLPPLSINGVSIGHTLLFLHKVTGDDVYLETAAEMA EYVLHKAPRFGEGILQHTVNAAEYVFPEQAWADTLMMAGLFMLRIGRVMEREDYFEDG LRQFHGHEDVLQDPVTNLYYHAWDNKAQNHLSGIYWGRANGWAALTMAKALPLIEVTH PSFMIIDGSLRDQLSALVRLQDESGLWHTILDDPDSYLEVSASAGIASALMSSGKLYT KYVQKSLAAILDAVEEDGRVSRVSAGTAVMKNAEGYKQVPYKRIQGWGQGLALTFLAD VLKTKKRLYQ*" /label="rhgH CDS" gene 666943..667977 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /label="rhgH gene" CDS 668000..670285 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19651770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19651770; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AraC/XylS family)" /protein_id="NP_388582.1" /db_xref="EnsemblGenomes-Gn:BSU07010" /db_xref="EnsemblGenomes-Tr:CAB12520" /db_xref="GOA:O31522" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG12853" /db_xref="UniProtKB/Swiss-Prot:O31522" /translation="MKKQPQQKERVSRWKGTYFKRNFVFILLIACIPGLLTGGAIYFL SIDKVEKELQRSHETQVAREVSRMDEKLGVLELALTQMAYDSSLMNGLAERDLEKDFT FSYQLTKKLFLLRDQQPLIEQASIFLNSPRPLVLSPEYSALTEQEALRKYRSLLASDH SIYWKRSGNQAMLIQLIPGAAEKPFGAIMLAVDPKEMESILQSLSPYPDGSALLLDQN REVLFHEGEKDFEKTLLHEIKKQPAENGHFQMEWKGKVYSVSFGEMNRMHQQWTFVSA APLSAITAPMVFLSKVIIVMLVICIGLAVCMTWYASKKIYRPIQHLLGLFTGGEKKTW QASGQDEFKWIEKRWQDLSLESRKLQQQLLRQTPHMKKSFLQHLLQSDFYYDNEESLR FRMEEAGWNIGGNVFHVLDLQVTGLRCEKSIFREGDEQLAVFTLTNIAEELAAKRVFQ LSILDIGRLSVTVLVMKTNSSDLKAYITELARQFGDVTGLCLTSTLSSKTERVTEIPS LFQDVKCGKSRRKFANRDQVIDLQADFPRDEQFAPYYPFELEKQIVQTIRLERKQEAK ELIDGCMKELSEKAAIDRHVHSALIQLFSRIQEDILHSGLNPSELFQHRNPFLDISEL REPNEAAAWLMDVVVTPYLSKLEGRKNRQQKQLAERVIAMIHEQYMADISLESCADAL GMNSYTLSKAFKQVTGINFIDYVTQIRIEKAKELLVNTNKKIHDVSEEVGYRHNYFNR IFKKQVGMPPGVFRQMYQETP*" /label="rhgR CDS" gene 668000..670285 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /label="rhgR gene" CDS 670299..670997 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 17957779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 17957779; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388583.1" /db_xref="EnsemblGenomes-Gn:BSU07020" /db_xref="EnsemblGenomes-Tr:CAB12521" /db_xref="GOA:O31523" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12854" /db_xref="UniProtKB/Swiss-Prot:O31523" /translation="MMKKPIQVFLAGDSTVSDCPPHEAPMAGWGQVFGQLFSEGVLVR NHAKGGASTNSFVEEGRLQAIAEHITQGDYLLIQFGHNDQKPRGTKPYSTFQQFLTLF ADTAREKGAHPVFVTSVQRRRFDENGRIEHTLGEYPDAMKALAKELDVPVIDLLAKTK VLYEAYGPEESKRLFVWFQPNEHPNYPDGIEDNTHFSEKGAMEVAKLVAEGIEELGLP LKDHLVSREGKEHV*" /label="rhgT CDS" gene 670299..670997 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /label="rhgT gene" CDS 670990..671652 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388584.1" /db_xref="EnsemblGenomes-Gn:BSU07030" /db_xref="EnsemblGenomes-Tr:CAB12522" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR015305" /db_xref="PDB:1OQ1" /db_xref="SubtiList:BG12855" /db_xref="UniProtKB/Swiss-Prot:O31524" /translation="MYKEGACLYRNPLRSKSDVKDWRMEGGGQISFDDHSLHLSHVQD EAHFVFWCPETFPDGIIVTWDFSPIEQPGLCMLFFAAAGIRGEDLFDPSLRKRTGTYP EYHSGDINALHLSYFRRKYAEERAFRTCNLRKSRGFHLAAMGADPLPSPDDADSPYRM KLIKDKGYVHFSINGLPILEWMDDGSTYGPVLTKGKIGFRQMAPMKAVYRDFAVHQAV RR*" /label="yesU CDS" gene 670990..671652 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /label="yesU gene" CDS 671649..672275 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane component" /protein_id="NP_388585.1" /db_xref="EnsemblGenomes-Gn:BSU07040" /db_xref="EnsemblGenomes-Tr:CAB12523" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12856" /db_xref="UniProtKB/Swiss-Prot:O31525" /translation="MKTTVTDALYAGCEAVVKIAWLNGLWLLFTLLGGVLFGWAPSTA AMCAVIRKWLMGQKDVPIFSLFLDTYKKEFLKVNAIGLAFSALLLILSANYHYFSAST NWLSFAVTSCTLLAGLLYIIALMYVFPLYVHYQLPLRKYIPQALLFGAMRPLTTGCML IGCGFVLYLLYTLPGLIPFYGPCLFGLVLMFFALRGFQKTEAQHHQAG*" /label="yesV CDS" gene 671649..672275 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /label="yesV gene" CDS 672396..674258 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /EC_number="4.2.2.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan endolyase" /protein_id="NP_388586.1" /db_xref="EnsemblGenomes-Gn:BSU07050" /db_xref="EnsemblGenomes-Tr:CAB12524" /db_xref="GOA:O31526" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2Z8R" /db_xref="PDB:2Z8S" /db_xref="PDB:2ZUX" /db_xref="SubtiList:BG12857" /db_xref="UniProtKB/Swiss-Prot:O31526" /translation="MRRSCLMIRRRKRMFTAVTLLVLLVMGTSVCPVKAEGAARQMEA LNRGLVAVKTDGGIFVSWRFLGTENASVLFNVYRDGQKLNAAPVKTTNYVDKNGSAGS TYTVRAVVNGTEQPASEKASVWAQPYHSVPLDKPAGGTTPKGESYTYSANDASVGDVD GDGQYELILKWDPSNSKDNSQDGYTGDVLIDAYKLDGTKLWRINLGKNIRAGAHYTQF MVYDLDGDGKAEVAMKTADGTKDGTGKVIGNANADYRNEQGRVLSGPEYLTVFQGSTG KELVTANFEPARGNVSDWGDSYGNRVDRFLAGIAYLDGQRPSLIMTRGYYAKTMLVAY NFRDGKLSKLWTLDSSKSGNEAFAGQGNHNLSIADVDGDGKDEIIFGSMAVDHDGKGM YSTGLGHGDALHTGDLDPGRPGLEVFQVHEDKNAKYGLSFRDAATGKILWGVYAGKDV GRGMAADIDPRYPGQEVWANGSLYSAKGVKIGSGVPSSTNFGIWWDGDLLREQLDSNR IDKWDYQNGVSKNMLTASGAAANNGTKATPTLQADLLGDWREEVVWRTEDSSALRIYT TTIPTEHRLYTLMHDPVYRLGIAWQNIAYNQPPHTSFFLGDGMAEQPKPNMYTP*" /label="rhgW CDS" gene 672396..674258 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /label="rhgW gene" promotor_no_box 672436..672536 /Source="Nicolas_upshift_promotors" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 672496 /Source="Nicolas_upshifts" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(673034) /Source="Nicolas_upshifts" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(673035..673054) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(673067..673076) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 674304..676142 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /EC_number="4.2.2.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan exolyase" /protein_id="NP_388587.1" /db_xref="EnsemblGenomes-Gn:BSU07060" /db_xref="EnsemblGenomes-Tr:CAB12525" /db_xref="GOA:O31527" /db_xref="InterPro:IPR013517" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2ZUY" /db_xref="SubtiList:BG12858" /db_xref="UniProtKB/Swiss-Prot:O31527" /translation="MKPKKRQMEYLTRGLIAVQTEQGVFVSWRFLGTDHETTAFHLYR DGKRITRDPIAESTNFLDQNGTADSVYQVAAVNKGREEKLSKKARVWQENVLEVPLAK PEGGVTPDGKPYTYSANDASVGDIDGDGEYEMILKWDPSNSKDNAHDGYTGEVLIDAY KLDGTFLWRINLGRNIRAGAHYTQFMVYDLDGDGKAEIAMKTADGTTDGKGHIIGDEQ ADFRNEQGRILSGPEYLTVFKGETGEALTTVEYEPPRGKLEDWGDGYGNRMDRFLAGT AYLDGERPSLVMARGYYTRTVLVAYDFRNGRLKKRWVFDSNQPGHEAYAGQGNHSLSV ADVDGDGKDEIIYGAMAVDHDGTGLYSTGLGHGDAMHVGDLDPSRKGLEVFQVHEDAT KPYGLSLRDAGTGEILWGVHAGTDVGRGMAAHIDPSYKGSLVWGIDPPGNDGMSYGLF TSKGEKISDKAPSSANFAIWWDGDLVRELLDHDWDGTIGRPKIEKWDAENGCLKTIFQ PAGVLSNNGTKGNPVLQANLFGDWREEVIWRTEDSSALRIYTTTHLTRHCFYTLMHDP VYRLGIAWQNTAYNQPPHTSFYLGTGMKKPPKPALYIAGSKAEAPL*" /label="rhgX CDS" gene 674304..676142 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /label="rhgX gene" CDS 676300..676953 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388588.1" /db_xref="EnsemblGenomes-Gn:BSU07070" /db_xref="EnsemblGenomes-Tr:CAB12526" /db_xref="GOA:O31528" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12859" /db_xref="UniProtKB/Swiss-Prot:O31528" /translation="MANHIYLAGDSTVQTYGDSTNQGGWGQFLGSHLPEHIQVINRAI GGRSSKTFVEEGRLQAILDVIEPDDWLFVQMGHNDASKNKPERYTEPYTTYKQYLKQY IAGAREKGAHPLLITPVARFHYENGVFLNDFPDYCIAMKQTAAEENVQLIDLMEKSLA FFTEKGEEKVYTYFMISEGINDYTHFTKKGANEMAKLVAKGIKELGLPLTESIIKER* " /label="yesY CDS" gene 676300..676953 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /label="yesY gene" CDS 676961..678952 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17056685, 17449691, 17485082" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17056685, 17449691, 17485082; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-galacturonidase" /protein_id="NP_388589.1" /db_xref="EnsemblGenomes-Gn:BSU07080" /db_xref="EnsemblGenomes-Tr:CAB12527" /db_xref="GOA:O31529" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12860" /db_xref="UniProtKB/Swiss-Prot:O31529" /translation="MRKLYHGACYYPELWDEETIQQDIDIMREVGVNVVRIGEFAWSV MEPEEGKIDVGFFKEIIARLYDSGIETIMCTPTPTPPIWFSHGRPERMHANEKREIMG HGSRQHACTNNPYFRKKAAIITTAIAKELGRLPGLIGWQLDNEFKCHVAECMCETCLR LWHDWLKNRYGVIERLNEAWGTDVWSETYQTFEQVPQPGPAPFLHHASLRTMYQLFSM EMIASFADEQAKIIRCYSDAPITHNGSVMFSVDNERMFQNLDFASYDTYASQENASAF LLNCDLWRNLKQGRPFWILETSPSYAASLESSAYPHADGYLQAEAVSSYALGSQGFCY WLWRQQRSGSEISHGSVLSAWGEPTIGYQNVLAVERARKEIEPIILSTEPVQAEAAMT YSDRAKAFIKTEPHRGLRHRSLVTHFYERILNTGIHRDLIPEGAPLDGYRLLFTPFVP YLSSEFIKKASAFAEAGGIWITGPLTGGRTCEHTIHTDCGLGELEKTSGIKTLFTFPM NENVNTGKAFGITAPLGLWSAVFDTESGNTLGTVEAGPGAGHAFLTERNYGEGKIVML GSLPSGKEGDAMLEALVRHYAEEAVISSRSDVTPGTIVAPRIGENGLVWIVVNMDGKG GSVTLPESGTDLLTHRLEKAGRLAVGPHEYRVIQFDNHS*" /label="rhgZ CDS" gene 676961..678952 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /label="rhgZ gene" CDS 678996..681569 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388590.2" /db_xref="EnsemblGenomes-Gn:BSU07090" /db_xref="EnsemblGenomes-Tr:CAB12528" /db_xref="SubtiList:BG12861" /db_xref="UniProtKB/Swiss-Prot:O31530" /translation="MKKIKWLSGQPKVTSGVTWGMPWKKGELKKGDRLALMNENAETR YVQSEPSAYWPDGSIKWTKHAAVFGGQENQSFTVHKREVPQPTESLSILETEHDIQVD TGALVCTIHKTGSDFIQSLQINGKPIAAGGRLVAIRETRKESAAKMVLLHERSVSFIK RAAIEQSGPVKAVVKIEGVHVLHKTYEEWLPFVIRLTFYAGLSEIGLVHTQLIDRSGK LEFVKGLGIEFDLFLEGEPYNRHFRFAGEKGMYKEPAQLFGTRKFNERYPLYEKQING EMLSPDEEHKEWFAHGTQNAVWDDVKIVQDSSDHYSLSKRTGKDYAWVGMLHGSRAKG LCYAGGKNGGVALGLRYFFEKYPSALEITGLAGSRPKMTIWLWPPDGEAMDLRHYTGN THVASAYEGFDEMRSDPTGIANTNEISLACFSHMPSDEVLNALADKWQAPPLIVCEPD VYYESKALGVWSIIDTSHPLKKELEEQLDAAFLFYKKEVEQRRWYGFWHYGDVMHTYD PIRHMWRYDLGGYAWQNNELVPTLWLWQAFFRSGREDIFRMAEAMTRHTSETDSFHLG EYAGLGSRHNVVHWGCGCKEARISMAGLHKFYYYLTGDDRTGDLLTEVKDADYALVKT DPMRAFYEKGKHPTHARTGPDWAAFCSNWLAEWERTENSEYLKKIETGINCLKRLPLR LLSGPTFEYDPATSMLHHMGDGIAGGYHMIIAFGAPQVWMELAELLDDWEWEDMLSEF GEFYTLSDEEKRKKSGGALHDGHFHWPMFAAGMTAYAARKKQDPHLAAKAWNLLLEDK LSHTPLPIKPERIETWTQLEELPWVTTNTVSQWCLNVIAALELIGDSLPAKKETSGKK G*" /label="yetA CDS" gene 678996..681569 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /label="yetA gene" promotor_-10 complement(680318..680336) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(680331) /Source="Nicolas_upshifts" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(680352..680357) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 681691..683199 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921237; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein transporter binding protein for alpha-galacturonides" /protein_id="NP_388591.1" /db_xref="EnsemblGenomes-Gn:BSU07100" /db_xref="EnsemblGenomes-Tr:CAB12529" /db_xref="GOA:P37966" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG10434" /db_xref="UniProtKB/Swiss-Prot:P37966" /translation="MKIRMRKKWMALPLAAMMIAGCSHSETSNSASGSKDTIKIMAPL LSPESPSDKSPSLKALEKYTGKEIKVTWVPDSSYNDKFNIVMASGEMPHAIVIKDKSA GFIKSVKAGAFWELSPYLKDYKNLSQADEKILKNSSVNGEVYGIYRTRDLIRACMIIR TDWLKNVGLDMPETLDDFYEVLKAFKEKDPDGNGKDDTYGMVVPKWMGLGNGSPWDVL QIWFGAPNRYGVENGKLIPDFTTKEYMDALTFFKKLYDEGLINKDFAVMDSAKWNDPV VKGKAGVIVDTGSRASQIQSAMEEADESNKDIIDIVGSLEGPNGKRTFPTSGYSGMIT IPKSSVKTEKELKEVLSFLDKMNDKEAQILTNNGVKGRNYELKDGVFTSLEKNNKSLL YEHEGLAQFSMSIPKSEYYIEDQKTKLFQHRKDIITEGEKIAVFNPAESLVSDVYTQK GAQLDNIILDARTQFIIGEIDEKGFDDAVELWKKSGGNELMKDLNKLYQSSK*" /label="lplA CDS" gene 681691..683199 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /label="lplA gene" CDS 683254..684210 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388592.1" /db_xref="EnsemblGenomes-Gn:BSU07110" /db_xref="EnsemblGenomes-Tr:CAB12530" /db_xref="GOA:P39128" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10435" /db_xref="UniProtKB/Swiss-Prot:P39128" /translation="METVPKKRDAPVLTAGKGISWMAALKRDKWLYLLLIPGLLYFLI FKYLPMWGVLIAFKDYSPYLGFWKSEWVGFDYFKDFFMNPDFFRLLRNTLMLASLDLL FAFPAPLILALLLNEVRKAVYKRCIQTFIYVPHFVSWTIVVSITFVFFTVDTGVINKL IMSLTGEQISFLSDADWFRPMIVMQSIWKETGWGTILFLAALATVDQEQYEAAIMDGA GRFRRMWHITLPAIRSTIIVLLILRIGSFLNLGFEQVYLMTNSLNRSVADIFDTYVYM MGITQGAYSYSTAVGLFKSVVGIILIFGANYIAKKFDQEGLF*" /label="lplB CDS" gene 683254..684210 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /label="lplB gene" downshifts complement(683528) /Source="Nicolas_upshifts" /id="D344" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="1.59638" /MaxDrop="4.19822" /score="13.9744253" /energy="-20.3" /TU="NA" /idTUdmin="U538" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(683554..683654) /Source="Nicolas_upshift_promotors" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(683594) /Source="Nicolas_upshifts" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 684224..685111 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388593.1" /db_xref="EnsemblGenomes-Gn:BSU07120" /db_xref="EnsemblGenomes-Tr:CAB12531" /db_xref="GOA:P39129" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10857" /db_xref="UniProtKB/Swiss-Prot:P39129" /translation="MAEIHTMHNTKAGRVFDVCNILFLGGVGAITILPFLYIIAGSFA TEAELAQRSFFIFPKTFTLDAYKYVFSTPTFLRSMGVSIFITVVGTAVQLFFTFTMAY PLAKRHVKGRNLLLNLVIFSMLFSGGMIPTYLVVKSLGLLDTYWALILPMAINPFNLI IIKNFFQQLPRELEESAKIDGCSEIGVFWRIALPLSKPVIATFALFYAVGIWNDFFHA LLYINDSAKWPLQMVLRQVTILSDLTATNGDTMQNAVPPEQGIKLAVIVIATLPILAV YPFLQKHFAKGMLIGSVKG*" /label="lplC CDS" gene 684224..685111 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /label="lplC gene" promotor_-35 684858..684863 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 684879..684897 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 684882 /Source="Nicolas_upshifts" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="upshifts" CDS 685120..686460 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23416295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23416295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-galacturonidase" /protein_id="NP_388594.1" /db_xref="EnsemblGenomes-Gn:BSU07130" /db_xref="EnsemblGenomes-Tr:CAB12532" /db_xref="GOA:P39130" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:3FEF" /db_xref="SubtiList:BG10858" /db_xref="UniProtKB/Swiss-Prot:P39130" /translation="MFHISTLDQIKIAYIGGGSQGWARSLMSDLSIDERMSGTVALYD LDFEAAQKNEVIGNHSGNGRWRYEAVSTLKKALSAADIVIISILPGSLDDMEVDVHLP ERCGIYQSVGDTVGPGGIIRGLRAVPIFAEIARAIRDYAPESWVINYTNPMSVCTRVL YKVFPGIKAIGCCHEVFGTQKLLAEMVTERLGIEVPRREDIRVNVLGINHFTWITKAS YRHIDLLPIFREFSAHYGESGYELEGECWRDSVFCSAHRVAFDLFETYGAIPAAGDRH LAEFLPGPYLKQPEVWKFHLTPISFRKQDRAEKRQETERLIVQQRGVAEKASGEEGVN IIAALLGLGELVTNVNMPNQGQVLNLPIQAIVETNAFITRNRVQPILSGALPKGVEML AARHISNQEAVADAGLTKDTGLAFQAFLNDPLVQIDRSDAEQLFNDMLQCIMQS*" /label="lplD CDS" gene 685120..686460 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /label="lplD gene" S_feature complement(685554..687245) /Source="Nicolas_S_feature" /locus_tag="new_783392_785083_c" /HighExp="H2O2, dia15, Paraq, Lbexp, LBGexp, Salt, LPhT, GM 25, G150, dia0" /AntisenseName="yetF" /AntisenseCor="-0.25986434675098202" /AntisenseRegPval="-4.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S247" S_feature 686461..686542 /Source="Nicolas_S_feature" /locus_tag="new_784299_784380" /HighExp="S5, S4, S6, S3, S7, S8, BT, LoTm, B36, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S248" CDS 686543..687238 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388595.1" /db_xref="EnsemblGenomes-Gn:BSU07140" /db_xref="EnsemblGenomes-Tr:CAB12533" /db_xref="GOA:O31533" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="PDB:3C6F" /db_xref="SubtiList:BG12862" /db_xref="UniProtKB/Swiss-Prot:O31533" /translation="MGNYLSVAVELVCGLGILFIILKLLGKTQFSQITPFDFISALIL GELVGNAVYDHEIKIKEIIFASLLWGVLIYIIEFITQKMKSSRKFLEGEPNIVIRKGE LQYKVMKKNKIDINQLQSLLRQAGSFSIQEVEYAILETNGMVSVLPKSDFDKPTNKDL QIPSKSVSLPITLIIDGEIVRDNLKEAGVDEQWLKQELKKKNIDKTEDVLFAEWHKNK PLYTVTYEQSRST*" /label="yetF CDS" gene 686543..687238 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /label="yetF gene" downshifts 687236 /Source="Nicolas_upshifts" /id="D345" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.32891" /MaxDrop="3.45213" /score="-0.176154378" /energy="-7.1" /TU="NA" /idTUdmin="U537" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(687275..687601) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /EC_number="1.14.14.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20180905, 21764939, 21873409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20180905, 21764939, 21873409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388596.2" /db_xref="EnsemblGenomes-Gn:BSU07150" /db_xref="EnsemblGenomes-Tr:CAB12534" /db_xref="GOA:O31534" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12863" /db_xref="UniProtKB/Swiss-Prot:O31534" /translation="MFVQLRKMTVKEGFADKVIERFSAEGIIEKQEGLIDVTVLEKNV RRGDEEVVVMIRWESEDHWKQWEKSDAHIAGHKANKGKPKPDYLISTEVSMYHVRAVK QGTYNQ*" /label="hmoA CDS" gene complement(687275..687601) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /label="hmoA gene" downshifts complement(687290) /Source="Nicolas_upshifts" /id="D346" /incds=0 /nref=194 /ntot=248 /MaxReadThrough="4.01189" /MaxDrop="6.29183" /score="9.23596913" /energy="-9.1" /TU="U538" /idTUdmin="U539" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 687588 /Source="Nicolas_upshifts" /id="D347" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.96802" /MaxDrop="3.46057" /score="-7.34187128" /energy="-5" /TU="NA" /idTUdmin="U537" /TUdmin=352 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(687624..687643) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(687642) /Source="Nicolas_upshifts" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(687658..687665) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(687705..688067) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase/dioxygenase" /protein_id="NP_388597.1" /db_xref="EnsemblGenomes-Gn:BSU07160" /db_xref="EnsemblGenomes-Tr:CAB12535" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12864" /db_xref="UniProtKB/Swiss-Prot:O31535" /translation="MIKQIGTVAVYVEDQQKAKQFWTEKVGFDIAADHPMGPEASWLE VAPKGAETRLVIYPKAMMKGSEQMKASIVFECEDIFGTYEKMKTNGVEFLGEPNQMEW GTFVQFKDEDGNVFLLKE*" /label="yetH CDS" gene complement(687705..688067) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /label="yetH gene" promotor_-10 complement(688090..688109) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-10" upshifts complement(688104) /Source="Nicolas_upshifts" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="upshifts" promotor_-35 complement(688122..688128) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-35" S_feature complement(688138..688698) /Source="Nicolas_S_feature" /locus_tag="new_785976_786536_c" /HighExp="S8, S6, S7, S5, BT, B36, G/S, B60, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S249" downshifts complement(688170) /Source="Nicolas_upshifts" /id="D348" /incds=0 /nref=38 /ntot=47 /MaxReadThrough="0.395850000000001" /MaxDrop="8.2984" /score="45.4672528" /energy="-13.7" /TU="NA" /idTUdmin="U540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(688681..688700) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(688698) /Source="Nicolas_upshifts" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(688714..688723) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 688786..688793 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 688802 /Source="Nicolas_upshifts" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 688806..688825 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 688851..689432 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; N-terminal part of YetI" /db_xref="SubtiList:BG12865" /translation="MNIDQLLYQYIIDNTADITEKWFSLRCQLKGELYSASHLSEETK TLLTEQHTFTNITIASAFLEDQTDFQENMTKWAQNVAKNRVEQDVQVHEVVEAISNSR ISFWDAVATFIKENQEIVTNEDADRWNRIVNQSFDKLIIEFSEQYQKFMLMRLTSQQE LISELGCPVISIADGIGILPLIGSIDTKRHRSF*" /label="yetI CDS" gene 688851..689432 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /pseudo /label="yetI gene" CDS 689426..689722 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; C-terminal part of YetI" /db_xref="GOA:O31537" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="PSEUDO:CAB12537.2" /db_xref="SubtiList:BG12873" /db_xref="UniProtKB/Swiss-Prot:O31537" /translation="MLETVPVRCVERKITSLVVDLSGVPIVDTMVAQQLYNLSKTLFL LGVKAVFSGIRPDVAQTSIQLGLDFSEYETYGTLKQALENMGVRCIVEELEENK*" /label="yetI CDS" gene 689426..689722 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /pseudo /label="yetI gene" downshifts 689714 /Source="Nicolas_upshifts" /id="D349" /incds=0 /nref=114 /ntot=215 /MaxReadThrough="1.06939" /MaxDrop="4.8053" /score="16.356572" /energy="-21.2" /TU="NA" /idTUdmin="U541" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 689793..689800 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 689814..689833 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 689822 /Source="Nicolas_upshifts" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 689877..690044 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388600.1" /db_xref="EnsemblGenomes-Gn:BSU07190" /db_xref="EnsemblGenomes-Tr:CAB12538" /db_xref="InterPro:IPR018743" /db_xref="SubtiList:BG12875" /db_xref="UniProtKB/Swiss-Prot:O31538" /translation="MVSKSTIDPEVIEKIISSLETLDFGTVQITVHDSQITQIEKIEK HRFSLKRKESK*" /label="yezD CDS" gene 689877..690044 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /label="yezD gene" promotor_-35 690086..690093 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 690109..690128 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 690110 /Source="Nicolas_upshifts" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 690154..690798 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /function="7.4: Cations and iron carrying compounds" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 16086852, 24904158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 16086852, 24904158; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pH-sensitive calcium-leak permease (di-aspartyl pH sensor)" /protein_id="NP_388601.1" /db_xref="EnsemblGenomes-Gn:BSU07200" /db_xref="EnsemblGenomes-Tr:CAB12539" /db_xref="GOA:O31539" /db_xref="InterPro:IPR006214" /db_xref="PDB:4PGR" /db_xref="PDB:4PGS" /db_xref="PDB:4PGU" /db_xref="PDB:4PGV" /db_xref="PDB:4PGW" /db_xref="PDB:4TKQ" /db_xref="SubtiList:BG12866" /db_xref="UniProtKB/Swiss-Prot:O31539" /translation="MQATVHESKQSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLP LSILEVAMIILAFWMRRRKAVGYAFVYTFAFVSGITLFPIVSHYASIAGAYVVLEAFG STFVIFAVLGTIGAKMKKDLSFLWSFLLVAVLALAVVGIFNIFSPLNSAAMMAYSVIG TIVFSLYILYDLNQIKHRHITEDLIPVMALSLYLDFINLFINLLRFFGILSSDD*" /label="calJ CDS" gene 690154..690798 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /label="calJ gene" downshifts 690734 /Source="Nicolas_upshifts" /id="D350" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="6.69003" /MaxDrop="2.5446" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U541" /TUdmin=1012 /isTUend="FALSE" /label="downshifts" downshifts 690778 /Source="Nicolas_upshifts" /id="D351" /incds=0 /nref=7 /ntot=127 /MaxReadThrough="5.33515" /MaxDrop="3.71552" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" CDS 690798..691790 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388602.1" /db_xref="EnsemblGenomes-Gn:BSU07210" /db_xref="EnsemblGenomes-Tr:CAB12540" /db_xref="GOA:O31540" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12867" /db_xref="UniProtKB/Swiss-Prot:O31540" /translation="MKKRLSLDRRFLPYIKKAGGVLVKKQMGAYVSLAAAMAIVGSSV VVGKLMVERIPVFLSSGLRFLIASVVLLMLLFCIEKGFPALTKKDVFVLLVQSFTGVF LFSICLLYGVQYTTGTESGILTSTTPMLIGILSFFLLREKIEKKTLIGILLAVCGVMA INLFGAGSQDGTPHALFGNMLIIAAVIGEALFTLMAKLLSPHISALAISTFVSLFGFL FFLPFALFEASSFDYSVPTVLDWSYVLYYALFVTVLAFYLWYSGVTKVPAGVSGIFTS VLPVSAVILSGVILKEPFEFVHFIGIACVIGGIFVTVIKKKQPDAYPAAEEKTL*" /label="yetK CDS" gene 690798..691790 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /label="yetK gene" downshifts 691724 /Source="Nicolas_upshifts" /id="D352" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="4.14475" /MaxDrop="2.73453" /score="21.8095329" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 691768 /Source="Nicolas_upshifts" /id="D353" /incds=0 /nref=94 /ntot=214 /MaxReadThrough="0.120229999999999" /MaxDrop="4.45909" /score="21.8095329" /energy="-10.7" /TU="NA" /idTUdmin="U542" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(691814..692317) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19329649, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19329649, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (FlvL-flavonoids)" /protein_id="NP_388603.1" /db_xref="EnsemblGenomes-Gn:BSU07220" /db_xref="EnsemblGenomes-Tr:CAB12541" /db_xref="GOA:O31541" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12868" /db_xref="UniProtKB/Swiss-Prot:O31541" /translation="MELKHLPKYKHITEHAETYANIDAGSLELFLSLFDISKKMNHVM EHYFAGRGLSEGKFKILMLLFDAKDHRLSPTELAKRSNVTKATITGLLDGLARDGFVS RRHHTEDKRKISIELTTEGKARLEQFLPGHFSKISAVMENYSDEEKDMFVKMLGDLFE RLSVFKD*" /label="flvL CDS" gene complement(691814..692317) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /label="flvL gene" promotor_-10 complement(692342..692361) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(692350) /Source="Nicolas_upshifts" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(692375..692382) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 692480..693589 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25209494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-dependent hydroxylase/monooxygenase acting on salicylate derivatives" /protein_id="NP_388604.1" /db_xref="EnsemblGenomes-Gn:BSU07230" /db_xref="EnsemblGenomes-Tr:CAB12542" /db_xref="GOA:O06489" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12869" /db_xref="UniProtKB/Swiss-Prot:O06489" /translation="MKHMLIAGGGIGGLSAAISLRKAGFSVTLCEAASENRKTGAGIL QPQNALAVLKELGVFEDCCKHGFQTEWFKTFDEQGNLLFQVSESFLDDSLPGRNNILR KTLNDILMKHAEAVGVDIKWGKKVVAYEETAESVTALCEDGEKMQADILAGFDGIHSV VRDKMLQKETEKEHLGMGAWRFYIELPDYTFEDATFMYRSGDTQIGVVPLAQHAGYVF VLQPCTSDYWDEEDTRFDRVKEILSGFRGLDFVTKHMSKQHPVIFNKLEQVAVQEPWH KGRVIIGGDAAHAGAPTLAQGAAMAIEDAIVLAEELQNHADHETALQAYYKRRAPRAL KVQNLSSEIVRRRLKGEPGAEELIGECYAVLREGY*" /label="flvM CDS" gene 692480..693589 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /label="flvM gene" downshifts 693572 /Source="Nicolas_upshifts" /id="D354" /incds=0 /nref=7 /ntot=67 /MaxReadThrough="0.0953400000000002" /MaxDrop="5.1482" /score="13.261567" /energy="-12.6" /TU="NA" /idTUdmin="U542" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS complement(693624..694694) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388605.1" /db_xref="EnsemblGenomes-Gn:BSU07240" /db_xref="EnsemblGenomes-Tr:CAB12543" /db_xref="InterPro:IPR025006" /db_xref="InterPro:IPR025012" /db_xref="SubtiList:BG12870" /db_xref="UniProtKB/Swiss-Prot:O06490" /translation="MDFEIRFLSFYVIQVEGKDEQANKQFKHFQTLDTGEFEESELKD FLDGELKKIVKRKADRHPQSEQVPTKIGHFIVEPGHELDSNPNYNMFNRARLAETKED FNELSEQFVRTYLDTSAVRGGVFLVASAVPRKYFDESFVFIMKCDFEPKVARISDASS LIKKVEMAITTKNMKSIQYPYMPEEGMVEEGELKIHQASHARYFEDFLKFVEYGESMP EIMKNQVMNMVQEHVYETFEDNSEELKQFEHDIEIWEASEKREIQERLDTHQVIEASA QIIEHTPEAQLKMKVGETEIKGLLADFGDSIHLAKVNGRYVALIEAETISFEKGSSPV EFYKPEGLHEVIERIRNKTEQD*" /label="yetN CDS" gene complement(693624..694694) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /label="yetN gene" downshifts complement(693648) /Source="Nicolas_upshifts" /id="D355" /incds=0 /nref=45 /ntot=180 /MaxReadThrough="0.83729" /MaxDrop="4.28938" /score="0.323038441" /energy="-11.6" /TU="NA" /idTUdmin="U545" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(694725..694744) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(694751) /Source="Nicolas_upshifts" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(694759..694766) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 694774..694780 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 694795..694813 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 694804 /Source="Nicolas_upshifts" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="upshifts" CDS 694844..698029 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /EC_number="1.6.2.4" /EC_number="1.14.14.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11574077, 2544578, 21048857, 26452461; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional P-450/NADPH-P450 reductase 1" /protein_id="NP_388606.1" /db_xref="EnsemblGenomes-Gn:BSU07250" /db_xref="EnsemblGenomes-Tr:CAB12544" /db_xref="GOA:O08394" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12871" /db_xref="UniProtKB/Swiss-Prot:O08394" /translation="MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQI HTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAH NILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGF NYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLV DSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLL SFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAF SLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHA YKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHIS VQSRHQEAIHADVQAAEKAAPDEQKEKTEAKGASVIGLNNRPLLVLYGSDTGTAEGVA RELADTASLHGVRTKTAPLNDRIGKLPKEGAVVIVTSSYNGKPPSNAGQFVQWLQEIK PGELEGVHYAVFGCGDHNWASTYQYVPRFIDEQLAEKGATRFSARGEGDVSGDFEGQL DEWKKSMWADAIKAFGLELNENADKERSTLSLQFVRGLGESPLARSYEASHASIAENR ELQSADSDRSTRHIEIALPPDVEYQEGDHLGVLPKNSQTNVSRILHRFGLKGTDQVTL SASGRSAGHLPLGRPVSLHDLLSYSVEVQEAATRAQIRELASFTVCPPHRRELEELSA EGVYQEQILKKRISMLDLLEKYEACDMPFERFLELLRPLKPRYYSISSSPRVNPRQAS ITVGVVRGPAWSGRGEYRGVASNDLAERQAGDDVVMFIRTPESRFQLPKDPETPIIMV GPGTGVAPFRGFLQARDVLKREGKTLGEAHLYFGCRNDRDFIYRDELERFEKDGIVTV HTAFSRKEGMPKTYVQHLMADQADTLISILDRGGRLYVCGDGSKMAPDVEAALQKAYQ AVHGTGEQEAQNWLRHLQDTGMYAKDVWAGI*" /label="cypD CDS" gene 694844..698029 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /label="cypD gene" downshifts 698016 /Source="Nicolas_upshifts" /id="D356" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.31156" /MaxDrop="2.91666" /score="9.17315362" /energy="-9.8" /TU="NA" /idTUdmin="U546" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 698079..698084 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 698100..698118 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 698121 /Source="Nicolas_upshifts" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 698149..698152 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 698169..698188 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 698170..698475 /Source="Nicolas_S_feature" /locus_tag="new_796008_796313" /HighExp="H2O2, Paraq, Oxctl, Cold, Heat, LBGexp, G180, G150, HPh, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.841" /TUlongSig="NA" /TUlongPSig="NA" /label="S250" upshifts 698170 /Source="Nicolas_upshifts" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" CDS 698476..700395 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11544192, 15187182, 17434969, 17483484, 21255105, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="exported glycerol phosphate lipoteichoic acid synthetase and anion-binding protein" /protein_id="NP_388607.2" /db_xref="EnsemblGenomes-Gn:BSU07260" /db_xref="EnsemblGenomes-Tr:CAB12545" /db_xref="GOA:Q797B3" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG12980" /db_xref="UniProtKB/Swiss-Prot:Q797B3" /translation="MKKLFSYKLSFFVLAVILFWAKTYLSYKTEFNLGVKGTTQEILL IFNPFSSAVFFLGLALLAKGRKSAIIMLIIDFLMTFVLYANILFYRFFDDFLTFPNIK QSGNVGNMGDGIFSIMAGHDIFYFLDIIILIAVLIWRPELKEYKMKKRFASLVILSGI ALFFINLHYAEKDRPQLLTRTFDRNYIVKYLGLYNYTIYDGVQTAQTETQRAYASSDD LTSVENYTTSHYAKPNAEYFGSAKGKNIIKIHLESFQSFLIDYKLNGEEVTPFLNKLA HGGEDVTYFDNFFHQTGQGKTSDAELTMDNSIFGLPEGSAFVTKGENTYQSLPAILDQ KEGYTSAVLHGDYKSFWNRDQIYKHIGYDKFFDASTYDMSDENVINMGLKDKPFFTES IPKLESLKQPFYAHLITLTNHYPFNLDEKDASLKKATTGDNTVDSYFQTARYLDEALE QFFKELKEAGLYDNSVIMIYGDHNGISENHNRAMKEILGKEITDYQNAQNQRVPLMIR VPGKKGGVNHTYGGEIDVMPTLLHLEGIDSQKYINFGTDLFSKDHDDTVAFRNGDFVT PKYTSVDNIIYDTKTGEKLKANEETKNLKTRVNQQLSLSDSVLYKDLLRFHKLNDFKA VDPSDYHYGKEKEIK*" /label="ltaSA CDS" gene 698476..700395 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /label="ltaSA gene" downshifts 700394 /Source="Nicolas_upshifts" /id="D357" /incds=0 /nref=103 /ntot=261 /MaxReadThrough="1.69168" /MaxDrop="7.8227" /score="37.7648461" /energy="-24" /TU="NA" /idTUdmin="U547" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 700483..700492 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 700502..700630 /Source="Nicolas_S_feature" /locus_tag="new_798340_798468" /HighExp="BT, B36, S8, S7, G/S, Pyr, B60, S6, Glucon, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S251" upshifts 700502 /Source="Nicolas_upshifts" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 700506..700525 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(700556) /Source="Nicolas_upshifts" /id="D358" /incds=0 /nref=2 /ntot=6 /MaxReadThrough="1.80969" /MaxDrop="4.63324" /score="20.6569889" /energy="-23.4" /TU="NA" /idTUdmin="U552" /TUdmin=4928 /isTUend="FALSE" /label="downshifts" CDS 700631..701395 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /EC_number="2.7.7.33" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15634670, 16357223, 26577401" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15634670, 16357223, 26577401; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate cytidylyltransferase (sporulation)" /protein_id="NP_388608.1" /db_xref="EnsemblGenomes-Gn:BSU07270" /db_xref="EnsemblGenomes-Tr:CAB12546" /db_xref="GOA:O06486" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR013446" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12979" /db_xref="UniProtKB/Swiss-Prot:O06486" /translation="MKAVILCGGKGTRMSEVTNDIPKPLAMIGGKPILWHIMKIYQYY GVNEFILLLGYKGEKIKEYFLDYEWKHNSLTLDSSTGEVQMLGQPETWKITFLETGVD TLTAGRILQAKDYIGDETFLLTYGDGLANINLFHLISYHQTKGAAATVTGIDKVSQFG TLTVEDGMAKTFSEKTSSDGIINGGFFVLSPKVFDYLPKDGNTMFEDEPLKNLAKDGE LAVYRHYGFWTAIDTYKNLLEVNKMWNQGQQVWKVW*" /label="spmH CDS" gene 700631..701395 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /label="spmH gene" CDS 701402..702370 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CDP-sugar-dehydratase/epimerase" /protein_id="NP_388609.2" /db_xref="EnsemblGenomes-Gn:BSU07280" /db_xref="EnsemblGenomes-Tr:CAB12547" /db_xref="GOA:O06485" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12978" /db_xref="UniProtKB/Swiss-Prot:O06485" /translation="MSFWKNKNVFVTGCTGLLGSYLVKELIEQGANVTGLVRDHVPQS NLYQGEHIKKMNIVRGSLEDLAVIERALGEYEIDTVFHLAAQAIVGVANRNPISTFEA NILGTWNILEACRKHPLIKRVIVASSDKAYGDQENLPYDENMPLQGKHPYDVSKSCAD LISHTYFHTYGLPVCITRCGNLYGGGDLNFNRIIPQTIQLVLNGEAPEIRSDGTFVRD YFYIEDAVQAYLLLAEKMEENNLAGEAFNFSNEIQLTVLELVEKILKKMNSNLKPKVL NQGSNEIKHQYLSAEKARKLLNWTPAYTIDEGLEKTIEWYTEFFKK*" /label="spmG CDS" gene 701402..702370 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /label="spmG gene" CDS 702394..703305 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388610.1" /db_xref="EnsemblGenomes-Gn:BSU07290" /db_xref="EnsemblGenomes-Tr:CAB12548" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12977" /db_xref="UniProtKB/Swiss-Prot:O06484" /translation="MTSAYCTVLSKGRLYQAVALFKSLEQVDQDSPIFILCMDEDTHR VLQKLKMKQLNLVPVAALENELLLKLKETRDQSEYCWTMKPIFLQAVLNSNPELERVT YIDGDLFFYADPSPIFENQPDCSVLLSRGDIVIPSFEKEQIDMLQRLLGRYNSGFISF KHDDAGTDCLEWWKERCLEECKNAPGEGKFGDQGYLDYMSELFPNVCDITTPGVNIGH WNYGQHTFSWKDGRIVLEDGSPLIFYHFSGYRIVSINEIKQIHETTRTDLPFVHELYQ ETLPHIIQHMQTLDPEFNGFASKDDNK*" /label="yfnF CDS" gene 702394..703305 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /label="yfnF gene" promotor_-35 703183..703192 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 703205..703224 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 703208 /Source="Nicolas_upshifts" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" CDS 703334..704512 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388611.1" /db_xref="EnsemblGenomes-Gn:BSU07300" /db_xref="EnsemblGenomes-Tr:CAB12549" /db_xref="GOA:O06483" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12976" /db_xref="UniProtKB/Swiss-Prot:O06483" /translation="MKASVIIPAYNSKERLYNSLLSLNQQECDEEFEVIVADNGSEDG TLSMLESFQADFPLIFTRIKENRGIAYGRNQALRNARGDILIFHDSDMLAAKDLVAKH IKAHENEENLVVCGLFWKRIYSFYYERFEEEHKEQLAKLTGEMPKKDKQKLLEEADIK NGSFLDKSFDLDTDFIDVLKKILDEYGDDLKGYHMPWRFFITNNSSVKRKHVVDLGLF DEGIVRYGFEDYDLGIRLHQAGLTFRLRRDIVSVHQEHPSNCKSVDDIRANIAYMCDK YNNIRSLDVHLAFNGPFPPDMTNRIMADIQKLLESQKYDMLLNLFLELLHVVKERNID PDWRKKSPRVTAKSFDLQTVRKLLPKAKKKLGVNDFANALYALVNDLLHVDLRSLDVV *" /label="yfnE CDS" gene 703334..704512 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /label="yfnE gene" promotor_-35 704053..704059 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 704074..704093 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 704088 /Source="Nicolas_upshifts" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 704513..705448 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388612.1" /db_xref="EnsemblGenomes-Gn:BSU07310" /db_xref="EnsemblGenomes-Tr:CAB12550" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12975" /db_xref="UniProtKB/Swiss-Prot:O31542" /translation="MSTFHFSTIVSRTHIFKLMPMIHSLHEHCDDFHLYVLCVDQKAY ELLQHVPWEHVTFVQLHEMEDPELLKAKSNRTFHEYCWTLKPAFLFHVMSKWDDAEYF AHMDTDLFFFSDPARIFAENPTASLYLTDHRNSPRFMSYYDRTGRFNTGFVGAGNTKE AYEAVWQWRQDCIEFCTVEMDTERKTYGDQRYVEKWPEQFKGVHVVKSIGANTALWNI ENYKVGQKDGRVYIDETPLIFYHFSGFTLVTEKEFNLCWYYRIEDEATIKMIYMPYIL NLKRWIDEIQSAFPDFADGFIPKHAVPDTHFIQLD*" /label="yfnD CDS" gene 704513..705448 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /label="yfnD gene" downshifts 705320 /Source="Nicolas_upshifts" /id="D359" /incds=1 /nref=1 /ntot=52 /MaxReadThrough="5.41459" /MaxDrop="2.6465" /score="34.8532284" /energy="-15.2" /TU="U549,U550" /idTUdmin="U549" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 705430 /Source="Nicolas_upshifts" /id="D360" /incds=0 /nref=2 /ntot=30 /MaxReadThrough="2.32849" /MaxDrop="5.65066" /score="34.8532284" /energy="-15.2" /TU="NA" /idTUdmin="U549" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(705471) /Source="Nicolas_upshifts" /id="D361" /incds=0 /nref=158 /ntot=249 /MaxReadThrough="1.15199" /MaxDrop="4.97014" /score="32.9697757" /energy="-15.2" /TU="NA" /idTUdmin="U552" /TUdmin=13 /isTUend="TRUE" /label="downshifts" CDS complement(705479..706708) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388613.1" /db_xref="EnsemblGenomes-Gn:BSU07320" /db_xref="EnsemblGenomes-Tr:CAB12551" /db_xref="GOA:O06481" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12974" /db_xref="UniProtKB/Swiss-Prot:O06481" /translation="MAIAAPLKEKTVQKPGTTVYPILIIIGICHMLNDSLQAVIPAMF PILERSMSLTFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPVGLTASMLGILG LAFAPSFITILCCVFFIGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMA PLITALILVPLGQFGAVWFTLVAALAVMFLMYIAKWYASRLGSLAQKSGKQKKTAENT AITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGA IGTFLGGPLADRFGKRFVILGSLLCSAPLAIVLPFAGPVLAYGVLALIGLVLMSSFSV TVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDAAGLTPTMIAIAFLPVLG ILAFLLPSDQKLREWHS*" /label="yfnC CDS" gene complement(705479..706708) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /label="yfnC gene" promotor_-10 complement(706737..706756) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(706755) /Source="Nicolas_upshifts" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(706772..706779) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(706819..707526) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine nucleotide phosphatase (promiscuous)" /protein_id="NP_388614.1" /db_xref="EnsemblGenomes-Gn:BSU07330" /db_xref="EnsemblGenomes-Tr:CAB12552" /db_xref="GOA:O06480" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR011951" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3ED5" /db_xref="PDB:3I76" /db_xref="SubtiList:BG12973" /db_xref="UniProtKB/Swiss-Prot:O06480" /translation="MKRYRTLLFDVDDTILDFQAAEALALRLLFEDQNIPLTNDMKAQ YKTINQGLWRAFEEGKMTRDEVVNTRFSALLKEYGYEADGALLEQKYRRFLEEGHQLI DGAFDLISNLQQQFDLYIVTNGVSHTQYKRLRDSGLFPFFKDIFVSEDTGFQKPMKEY FNYVFERIPQFSAEHTLIIGDSLTADIKGGQLAGLDTCWMNPDMKPNVPEIIPTYEIR KLEELYHILNIENTVSC*" /label="pynN CDS" gene complement(706819..707526) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /label="pynN gene" downshifts complement(706848) /Source="Nicolas_upshifts" /id="D362" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="2.75071" /MaxDrop="4.28644" /score="1.09492978" /energy="-15.7" /TU="NA" /idTUdmin="U553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(707549..707568) /Source="Nicolas_upshift_promotors" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(707572) /Source="Nicolas_upshifts" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(707618..709003) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12022921, 15849754, 16850406, 17114254, 18632116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 15849754, 16850406, 17114254, 18632116; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methylthioribose permease" /protein_id="NP_388615.1" /db_xref="EnsemblGenomes-Gn:BSU07340" /db_xref="EnsemblGenomes-Tr:CAB12553" /db_xref="GOA:Q797A7" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12972" /db_xref="UniProtKB/Swiss-Prot:Q797A7" /translation="MSSLFRKKPLETLSAQSKSKSLARTLSAFDLTLLGIGCVIGTGI FVITGTVAATGAGPALIISFILAGLACALAAFCYAEFSSSIPISGSVYSYSYVTLGEL LAFLIGWDLMLEYVIALSAVATGWSSYFQSLLAGFNLHIPAALTGAPGSMAGAVFNLP AAVIILLITAIVSRGVKESTRFNNVIVLMKIAIILLFIIVGIGYVKPDNWSPFMPFGM KGVILSAATVFFAYLGFDAVSNASEEVKNPQKNMPVGIISALAVCTVLYIAVSLVLTG MMPYAKLNVGDPVSFALKFVGQDAVAGIISVGAIIGITTVMLALLYAQVRLTFAMSRD GLLPGLFAKVHPSFKTPFRNTWLTGIVAAGIAGFINLGTLAHLVNMGTLAAFTVISIA VIVLRKKHPEIKASFRVPFVPVVPIISAGICLWFMYSLPGVTWLSFVIWIAVGTLVYF LYSRKHSLLNK*" /label="mtrA CDS" gene complement(707618..709003) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /label="mtrA gene" downshifts complement(707640) /Source="Nicolas_upshifts" /id="D363" /incds=0 /nref=8 /ntot=91 /MaxReadThrough="3.68565" /MaxDrop="4.73728" /score="31.1617384" /energy="-15.4" /TU="U554" /idTUdmin="U554" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(709052..709071) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(709069) /Source="Nicolas_upshifts" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(709086..709093) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 709171..709178 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 709186 /Source="Nicolas_upshifts" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 709192..709210 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 709253..710710 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /EC_number="1.2.1.67" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15033535, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vanillin dehydrogenase" /protein_id="NP_388616.1" /db_xref="EnsemblGenomes-Gn:BSU07350" /db_xref="EnsemblGenomes-Tr:CAB12554" /db_xref="GOA:O06478" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12971" /db_xref="UniProtKB/Swiss-Prot:O06478" /translation="MFQYEELNKQFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATA DDVDEAYRAAALAKKKWDAVNPFEKRTILEKAVTYIEENEEAIIYLIMEELGGTRLKA AFEIGLVKNIIKEAATFPIRMEGKILPSTIDGKENRLYRVPAGVVGVISPFNFPFFLS MKSVAPALGAGNGVVLKPHEETPICGGTLIAKIFENAGIPAGLLNVVVTDIAEIGDSF VEHPVPRIISFTGSTKVGSYIGQLAMKHFKKPLLELGGNSAFIVLEDADIEYAVNAAV FSRFTHQGQICMSANRVLVHSSIYDKFLELYQAKVESLKVGDPMDPDTIIGPLINSRQ TDGLMKTVEQAIEEGAVPVKLGGFNGTIVEPTILKDVKPFMSIAKEELFGPVVSFMKF DSEDEAVDIANETPFGLSGAVHTSNLERGVAFAKRIETGMIHVNDTTINDEPNVAFGG EKQSGLGRLNGEWSLEEFTTLKWISVQHEKRSFPY*" /label="vdhT CDS" gene 709253..710710 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /label="vdhT gene" promotor_-10 complement(710046..710065) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(710060) /Source="Nicolas_upshifts" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(710078..710087) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 710724..711584 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotaxis sensory transducer (sensed target unknown)" /protein_id="NP_388617.1" /db_xref="EnsemblGenomes-Gn:BSU07360" /db_xref="EnsemblGenomes-Tr:CAB12555" /db_xref="GOA:O06477" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="SubtiList:BG12970" /db_xref="UniProtKB/Swiss-Prot:O06477" /translation="MELTINTEKETADILDAFIKVAPYLNSLVQDDITIGIYDTEKLL VNIPAKTFSLNVKAGDPLQEGDIITDAIRSNQKKTSMVPKELFGFPLIARAIPLHDEN GRVIGGVGLGTSLEESSKLHDVAESLSAVVEQTAAAISDISESINGFSTQMSGISSQA KKVSESAGEIADISVTVKGISDQSNLLGLNAAIEAARAGESGKGFSVVADEIRKLATH SKENVGQIDQITKKIHSLLKGLEESIESINQHTDGQAAAVEQISATMQEISGSAQHLA KMAEKALEEE*" /label="yfmS CDS" gene 710724..711584 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /label="yfmS gene" downshifts 711568 /Source="Nicolas_upshifts" /id="D364" /incds=0 /nref=208 /ntot=237 /MaxReadThrough="2.9987" /MaxDrop="6.02377" /score="31.9989755" /energy="-16.7" /TU="U555" /idTUdmin="U555" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 711652..711659 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 711673..711692 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 711678 /Source="Nicolas_upshifts" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="upshifts" CDS 711719..713608 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /EC_number="3.6.3.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10715006, 16109936, 18848624, 19948254, 24389465, 24389466; Product type r : regulator" /codon_start=1 /transl_table=11 /product="putative energy-dependent translational throttleA" /protein_id="NP_388618.1" /db_xref="EnsemblGenomes-Gn:BSU07370" /db_xref="EnsemblGenomes-Tr:CAB12556" /db_xref="GOA:O06476" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12969" /db_xref="UniProtKB/Swiss-Prot:O06476" /translation="MSILKAENLYKTYGDKTLFDHISFHIEENERIGLIGPNGTGKST LLKVIAGLESIEEGEITKSGSVQVEFLHQDPELPAGQTVLEHIYSGESAVMKTLREYE KALYELGKDPENEQRQKHLLAAQAKMDANNAWDANTLAKTVLSKLGVNDVTKPVNELS GGQKKRVAIAKNLIQPADLLILDEPTNHLDNETIEWLEGYLSQYPGAVMLVTHDRYFL NRVTNRIYELERGSLYTYKGNYEVFLEKRAEREAQAEQKETKRQNLLRRELAWLRRGA KARSTKQKARIDRVETLKEQTGPQSSGSLDFAIGSHRLGKQVIEAENVMIAYDGRMLV DRFNELVIPGERIGIIGPNGIGKTTLLNALAGRHTPDGGDITIGQTVRIGYYTQDHSE MNGELKVIDYIKETAEVVKTADGDMITAEQMLERFLFPRSMQQTYIRKLSGGEKRRLY LLQVLMQEPNVLFLDEPTNDLDTETLSVLEDYIDQFPGVVITVSHDRYFLDRVVDRLI VFEGNGVISRFQGSYSDYMEESKAKKAAPKPAAEEKTAEAEPKKKRKKLSYKDQLEWD GIEDKIAQLEEKHEQLEADIAAAGSDFGKIQELMAEQAKTAEELEAAMDRWTELSLMI EELES*" /label="ettA CDS" gene 711719..713608 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /label="ettA gene" downshifts 713592 /Source="Nicolas_upshifts" /id="D365" /incds=0 /nref=2 /ntot=134 /MaxReadThrough="2.98669" /MaxDrop="2.72484" /score="30.3267801" /energy="-13.8" /TU="U557" /idTUdmin="U557" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" misc_feature 713672..713691 /Source="Nicolas_upshift_promotors" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 713680 /Source="Nicolas_upshifts" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="upshifts" CDS 713731..714177 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26483775" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388619.1" /db_xref="EnsemblGenomes-Gn:BSU07380" /db_xref="EnsemblGenomes-Tr:CAB12557" /db_xref="GOA:O06475" /db_xref="InterPro:IPR019723" /db_xref="SubtiList:BG12968" /db_xref="UniProtKB/Swiss-Prot:O06475" /translation="MTWAIVMLILMSLVKIVLTCLPTGVIEWLLGKFEVHAKLSDENA SLSLDGKRLEGAEKQKVIDQFNEAIFLEKYYIYPGDEERYLHPENGGTPLVIDTKKGK KDVKLFVYRYDDHIDVVKQYKKKVIAYRVLSESLQKESLSVAGSLA*" /label="yfmQ CDS" gene 713731..714177 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /label="yfmQ gene" downshifts complement(713733) /Source="Nicolas_upshifts" /id="D366" /incds=0 /nref=48 /ntot=154 /MaxReadThrough="1.16717" /MaxDrop="4.57866" /score="0.689181271" /energy="-10.2" /TU="NA" /idTUdmin="U559" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(713817..713820) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(713822) /Source="Nicolas_upshifts" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(713838..713839) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 714164 /Source="Nicolas_upshifts" /id="D367" /incds=0 /nref=254 /ntot=267 /MaxReadThrough="3.12706" /MaxDrop="7.87026" /score="13.6774886" /energy="-8" /TU="U558" /idTUdmin="U557" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 714240..714247 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 714261..714280 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 714273 /Source="Nicolas_upshifts" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="upshifts" CDS 714302..714724 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family) of metal(copper) efflux transporter expression" /protein_id="NP_388620.1" /db_xref="EnsemblGenomes-Gn:BSU07390" /db_xref="EnsemblGenomes-Tr:CAB12558" /db_xref="GOA:O06474" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG12967" /db_xref="UniProtKB/Swiss-Prot:O06474" /translation="MEWMKIDQVAKRSGLTKRTIRFYEEIGLIPAPKRTDGGVRLYSE DDMEELEKVISTKEVLGFSLQELQHFMETSRQLELNKEGYLLSLDPKERKEKLEEIQE TLNHQLDLIDEKIRTFQSFKERLQGMKGKAERAIQSIE*" /label="copP CDS" gene 714302..714724 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /label="copP gene" downshifts 714560 /Source="Nicolas_upshifts" /id="D368" /incds=1 /nref=2 /ntot=135 /MaxReadThrough="4.24358" /MaxDrop="2.69696" /score="13.6774886" /energy="-8" /TU="U560" /idTUdmin="U558" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS 714790..715980 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14663075, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="metal (copper) efflux transporter" /protein_id="NP_388621.1" /db_xref="EnsemblGenomes-Gn:BSU07400" /db_xref="EnsemblGenomes-Tr:CAB12559" /db_xref="GOA:O06473" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12966" /db_xref="UniProtKB/Swiss-Prot:O06473" /translation="MDKTTQVNQKTGLLSQPKAVWAVAFACVISFMGIGLVDPILPAI AAQLHASPSEVSLLFTSYLLVTGFMMFFSGAISSRIGAKWTLILGLIFIIVFAGLGGS SSSIAQLVGYRGGWGLGNALFISTALAVIVGVSVGGSAQAIILYEAALGLGISVGPLA GGELGSISWRAPFFGVSVLMFIALIAISFMLPKLPKPAKRVGVFDAMKALKYKGLLTM AVSAFLYNFGFFILLAYSPFVLDLDEHGLGYVFFGWGLLLAITSVFTAPLVHKALGTV RSLVVLFIAFAAILVIMGIWTDHQTLIITCIVVAGAVLGMVNTIMTTAVMGSAPVERS IASSAYSSVRFIGGALAPWIAGMLSEHFTASTPYTVGGIVVFVGMLVLLMGRKHLAGI KAGH*" /label="copO CDS" gene 714790..715980 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /label="copO gene" downshifts complement(716044) /Source="Nicolas_upshifts" /id="D369" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="-0.0437700000000003" /MaxDrop="2.92105" /score="-8.93016606" /energy="-11.6" /TU="NA" /idTUdmin="U562" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS 716271..716426 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388622.1" /db_xref="EnsemblGenomes-Gn:BSU07410" /db_xref="EnsemblGenomes-Tr:CAB12560" /db_xref="SubtiList:BG12965" /db_xref="UniProtKB/Swiss-Prot:O06472" /translation="MDKAKPDEYDQKCLETLYQYIHSVMKNSFSRSSGLPLGKMRRIL SCLPKES*" /label="yfmN CDS" gene 716271..716426 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /label="yfmN gene" CDS complement(716546..718102) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /EC_number="3.6.3.-" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 16109936, 16684363, 22333191, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388623.2" /db_xref="EnsemblGenomes-Gn:BSU07420" /db_xref="EnsemblGenomes-Tr:CAB12571" /db_xref="GOA:O34512" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12964" /db_xref="UniProtKB/Swiss-Prot:O34512" /translation="MSILSVKDLSHGFGDRAIFNNVSFRLLKGEHVGLIGANGEGKST FMNIITGKLEPDEGKVEWSKNVRVGYLDQHTVLEKGKSIRDVLKDAFHYLFAMEEEMN EIYNKMGEADPDELEKLLEEVGVIQDALTNNDFYVIDSKVEEIARGLGLSDIGLERDV TDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLKRYLQEYENAFILISHD IPFLNSVINLIYHVENQELTRYVGDYHQFMEVYEVKKQQLEAAYKKQQQEVAELKDFV ARNKARVSTRNMAMSRQKKLDKMDMIELAAEKPKPEFHFKPARTSGKLIFETKDLVIG YDSPLSRPLNLRMERGQKIALYGANGIGKTTLLKSLLGEIQPLEGSVERGEHIYTGYF EQEVKETNNNTCIEEVWSEFPSYTQYEIRAALAKCGLTTKHIESRVSVLSGGEKAKVR LCKLINSETNLLVLDEPTNHLDADAKEELKRALKEYKGSILLISHEPDFYMDIATETW NCESWTTKVL*" /label="ettM CDS" gene complement(716546..718102) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /label="ettM gene" downshifts complement(716570) /Source="Nicolas_upshifts" /id="D370" /incds=0 /nref=173 /ntot=264 /MaxReadThrough="0.35675" /MaxDrop="5.82627" /score="21.7805812" /energy="-12" /TU="NA" /idTUdmin="U562" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 717932..717938 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 717953..717964 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 717970 /Source="Nicolas_upshifts" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(718152..718171) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(718156) /Source="Nicolas_upshifts" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(718187..718191) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 718212..718215 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 718231..718250 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 718234 /Source="Nicolas_upshifts" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" CDS 718275..719405 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11976317; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_388624.1" /db_xref="EnsemblGenomes-Gn:BSU07430" /db_xref="EnsemblGenomes-Tr:CAB12572" /db_xref="GOA:O34750" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12963" /db_xref="UniProtKB/Swiss-Prot:O34750" /translation="MTQTWPFLHNAQSFIQENWNASGFQKPTPVQEQAAQLIMDGKDV IAESPTGTGKTLAYALPVLERIKPEQKHPQAVILAPSRELVMQIFQVIQDWKAGSELR AASLIGGANVKKQVEKLKKHPHIIVGTPGRVFELIKAKKLKMHEVKTIVLDETDQLVL PEHRETMKQIIKTTLRDRQLLCFSATLKKETEDVLRELAQEPEVLKVQRSKAEAGKVK HQYLICDQRDKVKLLQKLSRLEGMQALVFVRDIGNLSVYAEKLAYHHVELGVLHSEAK KMERAKIIATFEDGEFPLLLATDIAARGLDIENLPYVIHADIPDEDGYVHRSGRTGRA GKEGNVLSLVTKLEESKLKKMAKKLGVELSEAVYAGGKLKTK*" /label="yfmL CDS" gene 718275..719405 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /label="yfmL gene" downshifts 719388 /Source="Nicolas_upshifts" /id="D371" /incds=0 /nref=43 /ntot=133 /MaxReadThrough="2.93747" /MaxDrop="4.41385" /score="23.4253604" /energy="-5.9" /TU="NA" /idTUdmin="U563" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS 719473..719919 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388625.1" /db_xref="EnsemblGenomes-Gn:BSU07440" /db_xref="EnsemblGenomes-Tr:CAB12573" /db_xref="GOA:O34536" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12962" /db_xref="UniProtKB/Swiss-Prot:O34536" /translation="MASIDRFQVMQEPELKILEHWFENEDTRRRMDGMLLLDEWYARV NKDKHDTVIMAYDGQLPAGMVVIEFGEERTYIGLIVNPLYRLKGYGKQILQKLMTEPD FTSVREWVACIEEDNRISLACFQAAGFTLEDTEPDEDGFLTLILRN*" /label="yfmK CDS" gene 719473..719919 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /label="yfmK gene" CDS complement(719972..720991) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388626.1" /db_xref="EnsemblGenomes-Gn:BSU07450" /db_xref="EnsemblGenomes-Tr:CAB12574" /db_xref="GOA:O34812" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12961" /db_xref="UniProtKB/Swiss-Prot:O34812" /translation="MTASQQQIQLARRPQGIPVHEDFRFETIPVPEPKQGEVLVKTLY VSVDPYMRGRMQDTKSYVEPFALDKALSGGVIAEVVSDGNHLKKGDIVIGNLSWQEFS AVSESALRKIDTSLAPASAYLGILGMTGLTAYFGLLDIGRPKEGETVVVSGAAGAVGS TVGQIAKIKGARVVGIAGSDEKIDYLKQELQFDEAINYKTADDIQKALQNACPDGVDV YFDNVGGPISDAVMNLLNEFARIPVCGAISSYNAESEADDMGPRVQSKLIKTKSLMQG FIVSDYSDRFSEGAKQLAEWLKAGKLHYEETITEGFENIPDAFLGLFKGENKGKQLIK VSDPS*" /label="yfmJ CDS" gene complement(719972..720991) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /label="yfmJ gene" downshifts complement(719982) /Source="Nicolas_upshifts" /id="D372" /incds=0 /nref=183 /ntot=252 /MaxReadThrough="2.26899" /MaxDrop="5.73395" /score="20.8047206" /energy="-12.8" /TU="NA" /idTUdmin="U564" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(721012..721031) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(721016) /Source="Nicolas_upshifts" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(721018..721472) /Source="Nicolas_S_feature" /locus_tag="new_818856_819310_c" /HighExp="S2, S1, Pyr, T4.0H, T0.0H, T-2.40H, T3.30H, T-1.40H, T-0.40H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S252" promotor_-35 complement(721044..721051) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 721110..721117 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 721131..721150 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 721138..722235 /Source="Nicolas_S_feature" /locus_tag="new_818976_820073" /HighExp="Etha, dia5, Diami, C30, dia15, T5.0H, S8, T3.0H, M0t90, LPhT" /AntisenseName="yfmI" /AntisenseCor="0.135213889213362" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S253" upshifts 721138 /Source="Nicolas_upshifts" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="upshifts" CDS complement(721473..722693) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388627.1" /db_xref="EnsemblGenomes-Gn:BSU07460" /db_xref="EnsemblGenomes-Tr:CAB12575" /db_xref="GOA:O34440" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12960" /db_xref="UniProtKB/Swiss-Prot:O34440" /translation="MSKGYYSILFSQTTTNLGFSLYTMVVISFLFKMTNSTTIASMVT LISIIFRIFGSAILPLITIRLKLPLTIIISQLIQMLLLICLFYALLRTYSNQTLILVF IIISCISFFNGWFSPLKSAIIGEIISPDRRVKANGLLSTVDQTFQFVGWSLGGLIIAF LGEGYTIILTIFLLFTSLLSLLFCLPHGHANSVIREKNSPNKSIVSGWRYLFSQKKLR TIIIMDLIESWAGMIWIGSVSLAFVNEVLHKGESWWGFINGAYYLGSMIGGFIIYKLS ERFQNKLINFMLIGAVSYGSLTLIYGFISNSYLALILVLFMGPAYILRDLTQETLIQN ITTEQTRINIMSARSSLVQFIFMFSILAIGAISDFLGVRLVYVSAGILLLVSAIYGFS QLQFKKKVNKHISF*" /label="yfmI CDS" gene complement(721473..722693) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /label="yfmI gene" promotor_-10 complement(722730..722749) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(722737) /Source="Nicolas_upshifts" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(722765..722772) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 722791..722798 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 722810..722985 /Source="Nicolas_S_feature" /locus_tag="new_820648_820823" /HighExp="LoTm, T-1.10H, T-0.40H, S3, M9-stat, T0.0H, T-1.40H, BC, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.98260400000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S254" upshifts 722810 /Source="Nicolas_upshifts" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 722813..722832 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 722942 /Source="Nicolas_upshifts" /id="D373" /incds=0 /nref=34 /ntot=117 /MaxReadThrough="8.67835" /MaxDrop="8.45742" /score="4.02328636" /energy="-13.7" /TU="U567" /idTUdmin="U565" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 723029..724492 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388629.1" /db_xref="EnsemblGenomes-Gn:BSU07480" /db_xref="EnsemblGenomes-Tr:CAB12577" /db_xref="InterPro:IPR005532" /db_xref="InterPro:IPR016187" /db_xref="SubtiList:BG12958" /db_xref="UniProtKB/Swiss-Prot:O34722" /translation="MTLLMQDHKSIYNKDIEILIEVEELITSVPENKKNDFKSLIDNR IMTLLNKIQHPVAAENVFGMCIAYPNTYIRYRLIDFVEKWVPYFSAVETIINLTQDPD DLVSFKAMDVCANHKIEESVAYLSSIIDDVRESISYPKKPVGLGAQKVLSTLLDIFGV EKHEELVMLKNYFDQNGILPNNFDFEEKIPQSLIEEFEKTEEDGMILIPGGFFEFGLN ENEIPDKTFNWKDAVPRQKVWLPPFFIDKYPVTNKDYDIFTEFIEENGHIFCHPNEPQ NKQHRRNTYWDDRYLDNHPVTGIDFYDAFAYARYKGKELPTEFQWEKAARGEKGNVWP WGDKFDPAKVQYAGSLYNEPITSLKSWRENLLKAHADKELNHLTSDIFEQNGESPYGV CGMIGGTWEWTRSELKTKRAFHPIFENVPFNSVNSFAVLKGGSFFSHPGLMFPSFRAK DIPFCRHNEMGIRCVKNIPVYKIRESINGPITNKAIY*" /label="yfmG CDS" gene 723029..724492 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /label="yfmG gene" S_feature complement(723394..725064) /Source="Nicolas_S_feature" /locus_tag="new_821232_822902_c" /HighExp="H2O2, C30, Salt, Lbstat, dia15, LPhT, dia5, Paraq, HiOs, Diami" /AntisenseName="yfmG" /AntisenseCor="-0.58045119682782798" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S255" S_feature 724493..724986 /Source="Nicolas_S_feature" /locus_tag="new_822331_822824" /HighExp="LoTm, T0.0H, T-1.40H, T-0.40H, T-2.40H, T-1.10H, Pyr, T-3.40H, SMMPr, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S256" promotor_-35 724974..724979 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 724988..728253 /Source="Nicolas_S_feature" /locus_tag="new_822826_826091" /HighExp="LoTm, Pyr, B36, T3.30H, T2.0H, T-0.40H, T2.30H, B60, T4.0H, T3.0H" /AntisenseName="yfmE" /AntisenseCor="-0.61640022790163695" /AntisenseRegPval="-28.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S257" upshifts 724988 /Source="Nicolas_upshifts" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 724995..725013 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(725065..725865) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16672620, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (ATP-binding protein)" /protein_id="NP_388630.1" /db_xref="EnsemblGenomes-Gn:BSU07490" /db_xref="EnsemblGenomes-Tr:CAB12578" /db_xref="GOA:O34510" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12957" /db_xref="UniProtKB/Swiss-Prot:O34510" /translation="MGKLAADQLTLSYDSTVIIDGVDLKIEEGKITALIGANGCGKST ILKSLARLMAPKSGTVLLEGKDIHRQPSKEVAKKLAILPQSPQAPEGLTVEELCYFGR HPHKKLLSKHTQEDHDMVEWALEATGMIELKDRTLDALSGGQRQRAWISMALAQGTDL LLLDEPTTYLDISHQIEVLELLKKLNRDHGRTVVMVLHDLNQAAQYADYLISVLDGKI YNAGTPEDVFTQPFFREVFGLECCIMRSPIDQKPMCLPTGLCPKLRAK*" /label="fecF CDS" gene complement(725065..725865) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /label="fecF gene" CDS complement(725878..726879) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16672620, 16850406, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388631.1" /db_xref="EnsemblGenomes-Gn:BSU07500" /db_xref="EnsemblGenomes-Tr:CAB12579" /db_xref="GOA:O34832" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12956" /db_xref="UniProtKB/Swiss-Prot:O34832" /translation="MKKTTRKQKRPLLAILILAVILIVLSVISIGIGALYISPDAVVT NLLGLDHSFEFIIQQYRLPRIILAILAGAGLAAAGAILQGVIRNPLASPDVVGISKGS GLAAMAVILIFPESPVYVLPFSAFAGAAIIAVLLLMIARKKSIQPSSLALSGIALGAV CHAGMQYMMVKFPGDVNAALIWLTGSLWGRNWEEVKLLAPWLLILFPIVCILIPKLDL MSLGDELAQGLGENANRLRFILIFTAVALAGSCVAVVGSIGFIGLLAPHIARRLTGEK AKYLLPASALIGAIILLIADTLGRGIMPPVEIPAGILTAVIGAPYFLYLLKFEARKQ* " /label="fecE CDS" gene complement(725878..726879) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /label="fecE gene" promotor_-10 complement(726465..726484) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(726477) /Source="Nicolas_upshifts" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(726499..726506) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(726876..727877) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388632.1" /db_xref="EnsemblGenomes-Gn:BSU07510" /db_xref="EnsemblGenomes-Tr:CAB12580" /db_xref="GOA:O34933" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12955" /db_xref="UniProtKB/Swiss-Prot:O34933" /translation="MYHSAKRRSSSRLMMFIIALIIFIFGLGLNLSVGASDISIIDSL KYLFVWDGSKEQLIISTLRLPRTLIGVFVGASLAVAGALMQAMTRNPLASPQIFGVNA GASLFVVASLVILPASPYSSVIFAFAGAAAGGAIVYMIASSGGMTPVKLALSGMAVHL FLSSMTQAIIILNESGEDVLYWMTGAIDGSNWQDVITIAPFSVIGIGLALVFSGSVSV LGLGDETAKGLGQNMNGIRILISLIILILSGASVAVAGPIGFVGLLVPHIVRKLIGEH YQYVLPFSALFGAILLVYADVLARWIAFPYESPVGIVTAIIGTPFFLYLARKGRNLK* " /label="fecD CDS" gene complement(726876..727877) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /label="fecD gene" misc_feature complement(727947..727966) /Source="Nicolas_upshift_promotors" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(727949..728896) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (binding lipoprotein)" /protein_id="NP_388633.1" /db_xref="EnsemblGenomes-Gn:BSU07520" /db_xref="EnsemblGenomes-Tr:CAB12581" /db_xref="GOA:O34348" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12954" /db_xref="UniProtKB/Swiss-Prot:O34348" /translation="MRTYSNKLIAIMSVLLLACLIVSGCSSSQNNNGSGKSESKDSRV IHDEEGKTTVSGTPKRVVVLELSFLDAVHNLGITPVGIADDNKKDMIKKLVGSSIDYT SVGTRSEPNLEVISSLKPDLIIADAERHKNIYKQLKKIAPTIELKSREATYDETIDSF TTIAKALNKEDEGKEKLAEHKKVINDLKAELPKDENRNIVLGVARADSFQLHTSSSYD GEIFKMLGFTHAVKSDNAYQEVSLEQLSKIDPDILFISANEGKTIVDEWKTNPLWKNL KAVKNGQVYDADRDTWTRFRGIKSSETSAKDVLKKVYNK*" /label="fecC CDS" gene complement(727949..728896) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /label="fecC gene" downshifts complement(727968) /Source="Nicolas_upshifts" /id="D374" /incds=0 /nref=41 /ntot=211 /MaxReadThrough="4.92983" /MaxDrop="4.53674" /score="-3.64310934" /energy="-13.9" /TU="U570,U573,U574" /idTUdmin="U570" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" upshifts complement(727968) /Source="Nicolas_upshifts" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 728223..728228 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 728244..728262 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 728255..728880 /Source="Nicolas_S_feature" /locus_tag="new_826093_826718" /HighExp="LoTm, B36, S5, S6, S4, S7, S8, S3, BT, B60" /AntisenseName="yfmC" /AntisenseCor="-0.52042999587715499" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S258" upshifts 728255 /Source="Nicolas_upshifts" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="upshifts" misc_feature 728876..728895 /Source="Nicolas_upshift_promotors" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 728882..729413 /Source="Nicolas_S_feature" /locus_tag="new_826720_827251" /HighExp="LoTm, B36, S5, S4, S7, S6, S8, B60, S3, BT" /AntisenseName="yfmB" /AntisenseCor="-6.4915194654100006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.997, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S259" upshifts 728882 /Source="Nicolas_upshifts" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(728938..728957) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(728945) /Source="Nicolas_upshifts" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(728971..728978) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(729005..729373) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25651892" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388634.1" /db_xref="EnsemblGenomes-Gn:BSU07530" /db_xref="EnsemblGenomes-Tr:CAB12582" /db_xref="InterPro:IPR021579" /db_xref="PDB:2EUC" /db_xref="SubtiList:BG12953" /db_xref="UniProtKB/Swiss-Prot:O34626" /translation="MQYFSPEQQYNAWIVSDLVKQIFHKRAGCSPGIHELAVFAEEHF HIDIDFVFSIIMNIGDIEFALTDEIEKKLSGYLSTLLPYVTADMFETSKANAHAFLSR RHGNAAYHLFVSDDAFMRKQ*" /label="yfmB CDS" gene complement(729005..729373) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /label="yfmB gene" S_feature complement(729374..729486) /Source="Nicolas_S_feature" /locus_tag="new_827212_827324_c" /HighExp="Etha, BC, Sw, M9-stat, T3.30H, T1.30H, T3.0H, T5.0H, T2.30H, T2.0H" /AntisenseName="yfmA" /AntisenseCor="5.8024036419347599E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S260" promotor_-10 complement(729475..729494) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-10" upshifts complement(729486) /Source="Nicolas_upshifts" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="upshifts" promotor_-35 complement(729506..729513) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-35" promotor_-35 729554..729560 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 729574..729592 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 729574 /Source="Nicolas_upshifts" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 729617..729964 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12089032; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heat stress induced protein" /protein_id="NP_388636.1" /db_xref="EnsemblGenomes-Gn:BSU07550" /db_xref="EnsemblGenomes-Tr:CAB12584" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG19020" /db_xref="UniProtKB/Swiss-Prot:P80241" /translation="MKPVVKEYTNDEQLMKDVEELQKMGVAKEDVYVLAHDDDRTERL ADNTNANTIGAKETGFKHAVGNIFNKKGDELRNKIHEIGFSEDEAAQFEKRLDEGKVL LFVTDNEKVKAWA*" /label="yflT CDS" gene 729617..729964 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /label="yflT gene" downshifts complement(729618) /Source="Nicolas_upshifts" /id="D375" /incds=0 /nref=6 /ntot=28 /MaxReadThrough="1.00082" /MaxDrop="4.87687" /score="-3.31058364" /energy="-3.6" /TU="NA" /idTUdmin="U570" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" downshifts 729960 /Source="Nicolas_upshifts" /id="D376" /incds=0 /nref=56 /ntot=197 /MaxReadThrough="6.41566" /MaxDrop="7.61596" /score="-1.88723414" /energy="-5.6" /TU="U575" /idTUdmin="U567" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 730005..730085 /Source="Nicolas_S_feature" /locus_tag="new_827843_827923" /HighExp="Etha, Salt, B36, LoTm, Heat, B60, M9-stat, S8, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S261" misc_feature 730086..730105 /Source="Nicolas_upshift_promotors" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 730087 /Source="Nicolas_upshifts" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="upshifts" CDS 730155..731417 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8262178, 12823818, 27447541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8262178, 12823818, 27447541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pectate lyase" /protein_id="NP_388637.1" /db_xref="EnsemblGenomes-Gn:BSU07560" /db_xref="EnsemblGenomes-Tr:CAB12585" /db_xref="GOA:P39116" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="PDB:1BN8" /db_xref="PDB:2BSP" /db_xref="PDB:2NZM" /db_xref="PDB:2O04" /db_xref="PDB:2O0V" /db_xref="PDB:2O0W" /db_xref="PDB:2O17" /db_xref="PDB:2O1D" /db_xref="PDB:3KRG" /db_xref="PDB:5AMV" /db_xref="SubtiList:BG10840" /db_xref="UniProtKB/Swiss-Prot:P39116" /translation="MKKVMLATALFLGLTPAGANAADLGHQTLGSNDGWGAYSTGTTG GSKASSSNVYTVSNRNQLVSALGKETNTTPKIIYIKGTIDMNVDDNLKPLGLNDYKDP EYDLDKYLKAYDPSTWGKKEPSGTQEEARARSQKNQKARVMVDIPANTTIVGSGTNAK VVGGNFQIKSDNVIIRNIEFQDAYDYFPQWDPTDGSSGNWNSQYDNITINGGTHIWID HCTFNDGSRPDSTSPKYYGRKYQHHDGQTDASNGANYITMSYNYYHDHDKSSIFGSSD SKTSDDGKLKITLHHNRYKNIVQRAPRVRFGQVHVYNNYYEGSTSSSSYPFSYAWGIG KSSKIYAQNNVIDVPGLSAAKTISVFSGGTALYDSGTLLNGTQINASAANGLSSSVGW TPSLHGSIDASANVKSNVINQAGAGKLN*" /label="pelA CDS" gene 730155..731417 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /label="pelA gene" downshifts 731412 /Source="Nicolas_upshifts" /id="D377" /incds=0 /nref=139 /ntot=203 /MaxReadThrough="3.61256" /MaxDrop="5.92635" /score="1.82127533" /energy="-8.2" /TU="U575,U576" /idTUdmin="U576" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-35 731470..731473 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 731488..731507 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 731496 /Source="Nicolas_upshifts" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 731544..732980 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12949159, 15849754, 16850406, 25651892, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949159, 15849754, 16850406, 25651892, 28436820; Product type t : transporter" /codon_start=1 /transl_table=11 /product="malate (2-oxoglutarate) transporter" /protein_id="NP_388638.1" /db_xref="EnsemblGenomes-Gn:BSU07570" /db_xref="EnsemblGenomes-Tr:CAB12586" /db_xref="GOA:O34726" /db_xref="InterPro:IPR001898" /db_xref="InterPro:IPR030676" /db_xref="SubtiList:BG12951" /db_xref="UniProtKB/Swiss-Prot:O34726" /translation="MASEKDAGKQSAVKLVPLLITVAVGLIIWFIPAPSGLEPKAWHL FAIFVATIIGFISKPLPMGAIAIFALAVTALTGTLSIEDTLSGFGNKTIWLIVIAFFI SRGFIKTGLGARISYVFVQKFGKKTLGLSYSLLFSDLILSPAIPSNTARAGGIIFPII RSLSETFGSSPANGTERKIGAFLLKTGFQGNLITSAMFLTAMAANPLIAKLAHDVAGV DLTWTSWAIAAIVPGLVSLIITPLVIYKLYPPEIKETPDAAKIATEKLKEMGPFKKSE LSMVIVFLLVLVLWIFGGSFNIDATTTALIGLAVLLLSQVLTWDDIKKEQGAWDTLTW FAALVMLANFLNELGMVSWFSNAMKSSVSGFSWIVAFIILIVVYYYSHYFFASATAHI SAMYSAFLAVVVAAGAPPLLAALSLAFISNLFGSTTHYGSGAAPVFFGAGYIPQGKWW SIGFILSIVHIIVWLVIGGLWWKVLGIW*" /label="maeS CDS" gene 731544..732980 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /label="maeS gene" downshifts 732972 /Source="Nicolas_upshifts" /id="D378" /incds=0 /nref=56 /ntot=132 /MaxReadThrough="2.39993" /MaxDrop="5.36125" /score="40.3051497" /energy="-9.7" /TU="NA" /idTUdmin="U577" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature 733071..733090 /Source="Nicolas_upshift_promotors" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 733082 /Source="Nicolas_upshifts" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="upshifts" CDS 733107..734735 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388639.1" /db_xref="EnsemblGenomes-Gn:BSU07580" /db_xref="EnsemblGenomes-Tr:CAB12587" /db_xref="GOA:O34427" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12576" /db_xref="UniProtKB/Swiss-Prot:O34427" /translation="MVKKRFHFSLQTKIMGLIAALLVFVIGVLTITLAVQHTQGERRQ AEQLAVQTARTISYMPPVKELIERKDGHAAQTQEVIEQMKEQTGAFAIYVLNEKGDIR SASGKSGLKKLERSREILFGGSHVSETKADGRRVIRGSAPIIKEQKGYSQVIGSVSVD FLQTETEQSIKKHLRNLSVIAVLVLLLGFIGAAVLAKSIRKDTLGLEPHEIAALYRER NAMLFAIREGIIATNREGVVTMMNVSAAEMLKLPEPVIHLPIDDVMPGAGLMSVLEKG EMLPNQEVSVNDQVFIINTKVMNQGGQAYGIVVSFREKTELKKLIDTLTEVRKYSEDL RAQTHEFSNKLYAILGLLELGEYDEAIDLIKEEYAIQNEQHDLLFHNIHSQQVQAILL GKISKASEKKVKLVIDENSSLAPLPAHIGLSHLITIIGNLIDNAFEAVAEQSVKEVLF FITDMGHDIVIEVSDTGPGVPPEKIEAVFERGYSSKGMRRGYGLANVKDSVRELGGWI ELANQKTGGAVFTVFIPKEKQRGNPFDSHRDCGG*" /label="citS CDS" gene 733107..734735 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /label="citS gene" CDS 734707..735387 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388640.1" /db_xref="EnsemblGenomes-Gn:BSU07590" /db_xref="EnsemblGenomes-Tr:CAB12588" /db_xref="GOA:O34534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR028141" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12577" /db_xref="UniProtKB/Swiss-Prot:O34534" /translation="MIHIAIAEDDFRVAQIHERLIKQLDGFKIIGKAANAKETLALLK EHKADLLLLDIYMPDELGTALIPDIRSRFPEVDIMIITAATETRHLQEALRAGIAHYL IKPVTADKFRQVLLQYKEKRKLLMSQPEVSQSMIDHIFGNGVKTALPAEDLPTGINSI TLRKIKEALQTASEGLTAEELGEKMGASRTTARRYAEYLVSKEEARAELEYGIIGRPE RKYYLAAD*" /label="citT CDS" gene 734707..735387 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /label="citT gene" CDS 735390..736349 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11029430; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative tricarboxylate transporter component" /protein_id="NP_388641.2" /db_xref="EnsemblGenomes-Gn:BSU07600" /db_xref="EnsemblGenomes-Tr:CAB12589" /db_xref="GOA:O34439" /db_xref="InterPro:IPR005064" /db_xref="SubtiList:BG12950" /db_xref="UniProtKB/Swiss-Prot:O34439" /translation="MKKSIILLNILLIFMQGDIRQAAAPRLPDGPIEIVVPAEPSGGW DVTAQAIQSVLRQKQIVKDDVHIVYKSGGGGEKGWKYVNKSSKQTISMTSSLILSNDL LGQSKLKMSDFTPLAILSKEWQTVALPKGSALTNGKDVLNEINMHPGKVRIGFAPGFG NDDQLSFVRAADMYGIDPFDIQFSQYDSSEQLIQALIRHEIEAASMTLSEAKPYERNG DITLAAVTSDKRLPGFPNVPTWKEQGIPFVFSHWRGILGPKNMSEEEISYWDQALKKV TSSPEWKRKINEQDWESFYLNSRETKRFLEEQSAFYQSIMTGN*" /label="yflP CDS" gene 735390..736349 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /label="yflP gene" downshifts 736318 /Source="Nicolas_upshifts" /id="D379" /incds=0 /nref=76 /ntot=211 /MaxReadThrough="1.1681" /MaxDrop="6.31244" /score="10.4510496" /energy="-6.5" /TU="NA" /idTUdmin="U578" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 736441..736448 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 736461..736480 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 736472..736544 /Source="Nicolas_S_feature" /locus_tag="new_834310_834382" /HighExp="M9-stat, SMMPr, SMM, T0.0H, LoTm, T1.0H, Pyr, T1.30H, Cold, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S262" upshifts 736472 /Source="Nicolas_upshifts" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="upshifts" CDS 736545..737846 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="transporter of divalent metal ions/citrate complexes" /protein_id="NP_388642.1" /db_xref="EnsemblGenomes-Gn:BSU07610" /db_xref="EnsemblGenomes-Tr:CAB12590" /db_xref="GOA:P55069" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11832" /db_xref="UniProtKB/Swiss-Prot:P55069" /translation="MLAILGFLMMLVFMALIMTKRLSVLTALVLTPIVFALIAGFGFT EVGDMMISGIQQVAPTAVMIMFAILYFGIMIDTGLFDPMVGKILSMVKGDPLKIVVGT AVLTMLVALDGDGSTTYMITTSAMLPLYLLLGIRPIILAGIAGVGMGIMNTIPWGGAT PRAASALGVDPAELTGPMIPVIASGMLCMVAVAYVLGKAERKRLGVIELKQPANANEP AAAVEDEWKRPKLWWFNLLLTLSLIGCLVSGKVSLTVLFVIAFCIALIVNYPNLEHQR QRIAAHSSNVLAIGSMIFAAGVFTGILTGTKMVDEMAISLVSMIPEQMGGLIPAIVAL TSGIFTFLMPNDAYFYGVLPILSETAVAYGVDKVEIARASIIGQPIHMLSPLVPSTHL LVGLVGVSIDDHQKFALKWAVLAVIVMTAIALLIGAISISV*" /label="citM CDS" gene 736545..737846 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /label="citM gene" promotor_-35 737843..737849 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 737863..737874 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 737864 /Source="Nicolas_upshifts" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="upshifts" CDS 737902..738696 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10972810, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388643.1" /db_xref="EnsemblGenomes-Gn:BSU07620" /db_xref="EnsemblGenomes-Tr:CAB12591" /db_xref="GOA:O34409" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12949" /db_xref="UniProtKB/Swiss-Prot:O34409" /translation="MSDPYMPLTSVRSGAGFEAAKGVHGLTVQIANVYFIQLPSEPHS FVLIDAGMPQSAGVIVNEAKQRFGEGFQLKAIILTHGHFDHIGAIEEILEHWDVPVYI HSREMPYVTGKEDYPPARPDSKSGLVAKLSPLFPRHSIDISSHVQALPEDGSVPFLDE WMWIATPGHTPGHISLFRDDGRVLVAGDAVITVEQEKMADVLIQKQELHGPPAYFTPD TETAAESILKLAGLEPEALLTGHGIPMTGKNFRSDLTELANRLSSI*" /label="yflN CDS" gene 737902..738696 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /label="yflN gene" downshifts 738672 /Source="Nicolas_upshifts" /id="D380" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="0.0114999999999998" /MaxDrop="3.05232" /score="38.3109333" /energy="-11.8" /TU="NA" /idTUdmin="U580" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-35 738751..738754 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 738769..738788 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 738782 /Source="Nicolas_upshifts" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="upshifts" CDS 738815..739906 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /EC_number="1.14.13.39" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11856757, 12220171, 16172391, 25643072, 25826316, 26062720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11856757, 12220171, 16172391, 25643072, 25826316, 26062720; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitric-oxide synthase" /protein_id="NP_388644.2" /db_xref="EnsemblGenomes-Gn:BSU07630" /db_xref="EnsemblGenomes-Tr:CAB12592" /db_xref="GOA:O34453" /db_xref="InterPro:IPR004030" /db_xref="InterPro:IPR017142" /db_xref="InterPro:IPR036119" /db_xref="PDB:1M7V" /db_xref="PDB:1M7Z" /db_xref="PDB:2AMO" /db_xref="PDB:2AN0" /db_xref="PDB:2AN2" /db_xref="PDB:2FBZ" /db_xref="PDB:2FC1" /db_xref="PDB:2FC2" /db_xref="PDB:4D3I" /db_xref="PDB:4D3J" /db_xref="PDB:4D3K" /db_xref="PDB:4D3M" /db_xref="PDB:4D3N" /db_xref="PDB:4D3O" /db_xref="PDB:4D3T" /db_xref="PDB:4D3U" /db_xref="PDB:4D3V" /db_xref="PDB:4D7H" /db_xref="PDB:4D7I" /db_xref="PDB:4D7J" /db_xref="PDB:4LWA" /db_xref="PDB:4LWB" /db_xref="PDB:4UG5" /db_xref="PDB:4UG6" /db_xref="PDB:4UG7" /db_xref="PDB:4UG8" /db_xref="PDB:4UG9" /db_xref="PDB:4UGA" /db_xref="PDB:4UGB" /db_xref="PDB:4UGC" /db_xref="PDB:4UGD" /db_xref="PDB:4UGE" /db_xref="PDB:4UGF" /db_xref="PDB:4UGG" /db_xref="PDB:4UGH" /db_xref="PDB:4UGI" /db_xref="PDB:4UGJ" /db_xref="PDB:4UGK" /db_xref="PDB:4UGL" /db_xref="PDB:4UGM" /db_xref="PDB:4UGN" /db_xref="PDB:4UGO" /db_xref="PDB:4UGP" /db_xref="PDB:4UGQ" /db_xref="PDB:4UGR" /db_xref="PDB:4UGS" /db_xref="PDB:4UGT" /db_xref="PDB:4UGU" /db_xref="PDB:4UGV" /db_xref="PDB:4UGW" /db_xref="PDB:4UGX" /db_xref="PDB:4UGY" /db_xref="PDB:4UQR" /db_xref="PDB:4UQS" /db_xref="PDB:5G65" /db_xref="PDB:5G66" /db_xref="PDB:5G67" /db_xref="PDB:5G68" /db_xref="PDB:5G69" /db_xref="PDB:5G6A" /db_xref="PDB:5G6B" /db_xref="PDB:5G6C" /db_xref="PDB:5G6D" /db_xref="PDB:5G6E" /db_xref="PDB:5G6F" /db_xref="PDB:5G6G" /db_xref="PDB:5G6H" /db_xref="PDB:5G6I" /db_xref="PDB:5G6J" /db_xref="PDB:5G6K" /db_xref="PDB:5G6L" /db_xref="PDB:5G6M" /db_xref="PDB:5G6N" /db_xref="PDB:5G6O" /db_xref="PDB:5G6P" /db_xref="PDB:5G6Q" /db_xref="SubtiList:BG12948" /db_xref="UniProtKB/Swiss-Prot:O34453" /translation="MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGS YVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATN NGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGW RGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPII SDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLW KDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPI SPAATHIFHRSYDNSIVKPNYFYQDKPYE*" /label="nosA CDS" gene 738815..739906 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /label="nosA gene" CDS complement(739897..740172) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /EC_number="3.6.1.7" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:20447399" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20447399; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphatase" /protein_id="NP_388645.1" /db_xref="EnsemblGenomes-Gn:BSU07640" /db_xref="EnsemblGenomes-Tr:CAB12593" /db_xref="GOA:O35031" /db_xref="InterPro:IPR001792" /db_xref="InterPro:IPR017968" /db_xref="InterPro:IPR020456" /db_xref="InterPro:IPR036046" /db_xref="PDB:2FHM" /db_xref="PDB:2HLT" /db_xref="PDB:2HLU" /db_xref="PDB:3BR8" /db_xref="SubtiList:BG12947" /db_xref="UniProtKB/Swiss-Prot:O35031" /translation="MLQYRIIVDGRVQGVGFRYFVQMEADKRKLAGWVKNRDDGRVEI LAEGPENALQSFVEAVKNGSPFSKVTDISVTESRSLEGHHRFSIVYS*" /label="acyP CDS" gene complement(739897..740172) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /label="acyP gene" S_feature 739907..740238 /Source="Nicolas_S_feature" /locus_tag="new_837745_838076" /HighExp="C90, BI, Paraq, LBGexp, Oxctl, M0t45, G150, M40t45, G135, H2O2" /AntisenseName="yflL" /AntisenseCor="0.38657275217332299" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S263" promotor_-10 complement(740186..740205) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(740200) /Source="Nicolas_upshifts" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(740220..740227) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 740239..740904 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11886751; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur carrier" /protein_id="NP_388646.1" /db_xref="EnsemblGenomes-Gn:BSU07650" /db_xref="EnsemblGenomes-Tr:CAB12594" /db_xref="GOA:O34542" /db_xref="InterPro:IPR005163" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="SubtiList:BG12946" /db_xref="UniProtKB/Swiss-Prot:O34542" /translation="MKQERYSVLSLNLGKPQTLEYDGKKIETGIMKRPAKSAVMLYRE NFEGDGQADLVNHGGPDKAVCVYPAEHYPFWEEFLSRPLSNAAFGENLTVAGLTEENV CIGDVFRLDEAVVQVSQPRQPCVKLAKKFGVKEMVLKVQQTGYTGFYFRVLEEGRVSP GANLELLSRGEKGISVQFANRINYHDAKNLTAIERILSEAALSESWRASFMKKKDRLL PVE*" /label="yflK CDS" gene 740239..740904 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /label="yflK gene" CDS complement(740945..741082) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388647.1" /db_xref="EnsemblGenomes-Gn:BSU07660" /db_xref="EnsemblGenomes-Tr:CAB12595" /db_xref="InterPro:IPR022580" /db_xref="SubtiList:BG12945" /db_xref="UniProtKB/Swiss-Prot:O34345" /translation="MHYGSKGWYVAELKKQGITHHEGRKLQSYKTYFLANLLESKKKQ S*" /label="yflJ CDS" gene complement(740945..741082) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /label="yflJ gene" downshifts complement(740959) /Source="Nicolas_upshifts" /id="D381" /incds=0 /nref=136 /ntot=260 /MaxReadThrough="0.0927600000000002" /MaxDrop="8.10929" /score="29.8336543" /energy="-14.8" /TU="NA" /idTUdmin="U583" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(741083..741213) /Source="Nicolas_S_feature" /locus_tag="new_838921_839051_c" /HighExp="S4, S7, S8, S6, S5, S3, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.967, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S264" promotor_-10 complement(741199..741217) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 741209..741214 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(741213) /Source="Nicolas_upshifts" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 741224..742288 /Source="Nicolas_S_feature" /locus_tag="new_839062_840126" /HighExp="S8, S6, S5, S7, S4, S3, BT, B36, C90, T5.0H" /AntisenseName="mapB" /AntisenseCor="-0.26446079057314398" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S265" upshifts 741225 /Source="Nicolas_upshifts" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 741230..741248 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(741233..741238) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(741239..741394) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388648.1" /db_xref="EnsemblGenomes-Gn:BSU07670" /db_xref="EnsemblGenomes-Tr:CAB12596" /db_xref="GOA:O34905" /db_xref="SubtiList:BG12944" /db_xref="UniProtKB/Swiss-Prot:O34905" /translation="MWFIIFGIIFFIEGIIMTVYGVKKKNGMLTYIGIVFAIMTFGVV MIKLTGH*" /label="yflI CDS" gene complement(741239..741394) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /label="yflI gene" S_feature complement(741395..741500) /Source="Nicolas_S_feature" /locus_tag="new_839233_839338_c" /HighExp="Etha, Salt, Diami, dia15, H2O2, Cold, G135, Paraq, LPhT, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S266" CDS complement(741501..741815) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1070366, 1266368; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388649.1" /db_xref="EnsemblGenomes-Gn:BSU07680" /db_xref="EnsemblGenomes-Tr:CAB12597" /db_xref="InterPro:IPR021637" /db_xref="PDB:3D0W" /db_xref="SubtiList:BG12943" /db_xref="UniProtKB/Swiss-Prot:O34306" /translation="MNRDQEKIQIENEMNAMHGTIKEDILKDFEEFKGYLKKQVNRGK KLGLDDGKLVKSAAILGDYLAKHEEPQNGEEMLLQELWSVADEDEKEHLAQLLVKLVD KQ*" /label="yflH CDS" gene complement(741501..741815) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /label="yflH gene" S_feature complement(741816..741896) /Source="Nicolas_S_feature" /locus_tag="new_839654_839734_c" /HighExp="dia5, dia15, Diami, LBGtran, LPhT, H2O2, Etha, Lbtran, M40t45, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S267" CDS complement(741897..742646) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase B" /protein_id="NP_388650.1" /db_xref="EnsemblGenomes-Gn:BSU07690" /db_xref="EnsemblGenomes-Tr:CAB12598" /db_xref="GOA:O34484" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG12942" /db_xref="UniProtKB/Swiss-Prot:O34484" /translation="MIVTNDQELEGLKKIGRIVALAREEMKRKAEPGMSTKDLDLIGK AVLDEHGAVSAPEKEYDFPGVTCISVNDEVAHGIPSTSKILKAGDLVNIDISAEFGGF YSDTGISFVLGEGEERLHKLCQCAENAFQKGLQQAKAGKRQNQIGRAVYHEARSQGFT VIKTLTGHGIGRSLHEAPNHIMNYYDPFDNALFKNGTVIALEPFISTKAETIVEAGDG WTFKTPDKSMVAQVEHTIVITKDEPIILTKL*" /label="mapB CDS" gene complement(741897..742646) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /label="mapB gene" promotor_-10 complement(742675..742694) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(742688) /Source="Nicolas_upshifts" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(742690..743826) /Source="Nicolas_S_feature" /locus_tag="new_840528_841664_c" /HighExp="S6, S8, S7, S5, BT, C30, Paraq, B36, G180, Pyr" /AntisenseName="nagP" /AntisenseCor="0.180776000778922" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S268" promotor_-35 complement(742706..742714) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 742757..742758 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 742778..742797 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 742781 /Source="Nicolas_upshifts" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="upshifts" CDS 742818..744176 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 8246840; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) N-acetylglucosamine-specific enzyme IICB component" /protein_id="NP_388651.1" /db_xref="EnsemblGenomes-Gn:BSU07700" /db_xref="EnsemblGenomes-Tr:CAB12599" /db_xref="GOA:O34521" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010974" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG12941" /db_xref="UniProtKB/Swiss-Prot:O34521" /translation="MLSFLQKLGKSFMLPIAVLPAVGIILALGREDVFNIPFVYQAGT AVFDHLPLIFAIGIAIGISKDSNGAAGLSGAISYLMLDAATKTIDKTNNMAVFGGIIA GLIAGYTYNRFKDTKLPEYLGFFSGRRLVPILTAIITIILAGIFGVVWPPIQSCINSF GEWMLGLGGIGAGIFGLFNRLLIPLGLHHVLNNIFWFQFGEYNGVTGDLARFFAKDPT AGTYMTGFFPIMMFGLPAACLAMVVTAKPSKRKATAGMMIGFALTAFITGITEPIEFA FMFLSPLLYAVHAVLTGLSLFIVNWLGIRSGFSFSAGAIDYVLSYGIAEKPLLLLLVG ICYAAVYFIVFYVLIKALNLKTPGREDDDVDEVLDENTVQDVNENIMLKGLGGKENLQ TIDHCATRLRLTVKDTALVDEALLKKAGAKGVVKSGGQSVQVIIGPNVEFAAEELRAA VK*" /label="nagP CDS" gene 742818..744176 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /label="nagP gene" promotor_-10 complement(743812..743831) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(743826) /Source="Nicolas_upshifts" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(743845..743854) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 744062 /Source="Nicolas_upshifts" /id="D382" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="3.67421" /MaxDrop="3.12268" /score="44.7832762" /energy="-16.9" /TU="U586" /idTUdmin="U586" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 744172 /Source="Nicolas_upshifts" /id="D383" /incds=0 /nref=2 /ntot=87 /MaxReadThrough="2.54331" /MaxDrop="3.17508" /score="44.7832762" /energy="-16.9" /TU="NA" /idTUdmin="U586" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(744209..746158) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10658653, 21255105" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658653, 21255105; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_388652.1" /db_xref="EnsemblGenomes-Gn:BSU07710" /db_xref="EnsemblGenomes-Tr:CAB12600" /db_xref="GOA:O34952" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="PDB:2W8D" /db_xref="SubtiList:BG12940" /db_xref="UniProtKB/Swiss-Prot:O34952" /translation="MKTFIKERGLAFFLIAVVLLWIKTYVGYVLNFNLGIDNTIQKIL LFVNPLSSSLFFLGFGLLFKKKLQQTAIIVIHFLMSFLLYANIVYYRFFNDFITIPVI MQAKTNGGQLGDSAFSLMRPTDAFYFIDTIILIILAIKVNKPAETSSKKSFRIIFASS ILVFLINLAVAESDRPELLTRSFDRNYLVKYLGTYNFTIYDAVQNIKSNSQRALADSS DVTEVENYMKANYDVPNNVYFGKAEGKNVIYVSLESLQSFIIDYKIDGKEVTPFLNKL AHDNETFYFDNFFHQTGQGKTSDAEFMMENSLYPLAQGSVFVNKAQNTLQSVPAILKS KNYTSATFHGNTQTFWNRNEMYKAEGIDKFFDSAYYDMNEENTKNYGMKDKPFFKESM PLLESLPQPFYTKFITLSNHFPFGMDEGDTDFPAGDFGDSVVDNYFQSAHYLDQSIEQ FFNDLKKDGLYDKSIIVMYGDHYGISENHNKAMAKVLGKDEITDYDNAQLQRVPLFIH AAGVKGEKVHKYAGDVDVAPTILHLLGVDTKDYLMSGSDILSKEHREVIPFRNGDFIS PKYTKISGKYYDTKTGKELDESEVDKSEDSLVKKELEMSDKIINGDLLRFYEPKGFKK VNPSDYDYTKHDEDSSETSKDNEDK*" /label="ltaSB CDS" gene complement(744209..746158) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /label="ltaSB gene" downshifts complement(744226) /Source="Nicolas_upshifts" /id="D384" /incds=0 /nref=219 /ntot=250 /MaxReadThrough="1.71031" /MaxDrop="6.08461" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U589" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 745268..745274 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 745290..745308 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 745294..746258 /Source="Nicolas_S_feature" /locus_tag="new_843132_844096" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, S8, B60, BC, S7" /AntisenseName="yflE" /AntisenseCor="-0.385555454026206" /AntisenseRegPval="-10.199999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S269" upshifts 745294 /Source="Nicolas_upshifts" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(746159..746233) /Source="Nicolas_S_feature" /locus_tag="new_843997_844071_c" /HighExp="Paraq, H2O2, LBGexp, G150, G135, G180, Lbexp, C30, LPhT, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S270" promotor_-10 complement(746210..746229) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(746233) /Source="Nicolas_upshifts" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(746235..746757) /Source="Nicolas_S_feature" /locus_tag="new_844073_844595_c" /HighExp="S3, LoTm, S7, S4, S5, S8, S6, M9-stat, C30, Pyr" /AntisenseName="yflD" /AntisenseCor="0.24383322556613099" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S271" promotor_-35 complement(746245..746249) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 746259..746396 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388653.1" /db_xref="EnsemblGenomes-Gn:BSU07720" /db_xref="EnsemblGenomes-Tr:CAB12601" /db_xref="SubtiList:BG12939" /db_xref="UniProtKB/Swiss-Prot:O34489" /translation="MREKVAKNAVESTFRFDITKCKTRYLSRNKGIKWYIENCMIKYK V*" /label="yflD CDS" gene 746259..746396 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /label="yflD gene" upshifts 746374 /Source="Nicolas_upshifts" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="upshifts" misc_feature 746375..746394 /Source="Nicolas_upshift_promotors" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 746415..746807 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388655.2" /db_xref="EnsemblGenomes-Gn:BSU07735" /db_xref="EnsemblGenomes-Tr:CAB12603" /db_xref="InterPro:IPR018961" /db_xref="SubtiList:BG12937" /db_xref="UniProtKB/Swiss-Prot:O34887" /translation="MDFSHIVSEDKIKRAIKDGDFQNLPGMGKPLPKDDAAHLPESLR MGYRILKNAGMAEDEGALKKELMTIDHLIEKCYDEKEREQLIRKKSEKQLLLDKLVDK KGMFSKPASAFYKNKVYDRLGRNRPSSS*" /label="yflB CDS" gene 746415..746807 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /label="yflB gene" promotor_-10 complement(746755..746773) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(746770) /Source="Nicolas_upshifts" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(746789..746794) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 746876..746882 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 746897..746915 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 746897 /Source="Nicolas_upshifts" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="upshifts" CDS 746932..748347 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid transporter" /protein_id="NP_388656.1" /db_xref="EnsemblGenomes-Gn:BSU07750" /db_xref="EnsemblGenomes-Tr:CAB12604" /db_xref="GOA:O34708" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12936" /db_xref="UniProtKB/Swiss-Prot:O34708" /translation="MERLLVWIEHISDWLWGPPLIILLTGTGLYFTILLKGFQFRYPL YIFKQTIGSVGKKPKGEGTVTPLQALTSALSSTIGAANIVGVPAAIMFGGPGAVFWMW LIALFAMAIKFSESVLAVHYREKNEQGEYVGGPMYYITKGLRMKWLGVFFSVALIVEL IPSIMVQGNSVSVSLAETFSFNKIYAGIGIAFLIGLVVIGGVKRIGKVTEFVVPLMAG AYAGAGLLIVLMNLSSVPAFFSLVFSNAFTSSSAVGGFAGAALAETVRWGFARGLYSN EAGMGTAPIAHAAAMTDHPVRQGFWSVIGIVIDTLIICTTTAFIVLASGVWTGKNASN DPAALTTAAFQHYFGSGGGYFVSVSLVFFVVSTIMVVIFYGVKQAEFLFGRLAGHVIK FVYLAAIIIGAAGGAKAIWGVLDLALVFIVVPNVIALLLLSRKVKALYTEFFTSEQYY LKDIRKTKQKPVYPTKEAKNS*" /label="yflA CDS" gene 746932..748347 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /label="yflA gene" downshifts complement(746933) /Source="Nicolas_upshifts" /id="D385" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="0.76492" /MaxDrop="4.20973" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U593" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(746959..747059) /Source="Nicolas_upshift_promotors" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(746999) /Source="Nicolas_upshifts" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(748344..749420) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406, 23625846; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane transporter" /protein_id="NP_388657.1" /db_xref="EnsemblGenomes-Gn:BSU07760" /db_xref="EnsemblGenomes-Tr:CAB12605" /db_xref="GOA:O34573" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG12935" /db_xref="UniProtKB/Swiss-Prot:O34573" /translation="MDKTSAYQGLFFGALYTLAVGLKHAPILMIESAKQNAWHSYILG VVIVIPALWLMHRLMKKHQDKNIYELLSDSSPIAGRIIILLFSLYFLLINAHDIRFFI NLINILFLPRTPMAVLGGVIIFVAICIAREGKETLTRMAQIFLFPFGILVLFLPFTLA TQIELQNLTPVFEGLIPYLQSGYYAFGTMGELIILPLLFSNRSVPLKYTIFAILLGAL LLAVMLFSSISVFGPNLTSTFFDPAYMVIRQIRITDFLDRSDLIIAAFWIPVIMVKIA GSLYIVVYGLSFLHSKIDPKAMYTPTGMFSVVCGFWFFLNTNQLIDFNRIKPIINVVI SLLLPLLIYLIIKSKALFGAKAKH*" /label="yfkT CDS" gene complement(748344..749420) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /label="yfkT gene" S_feature 748348..751714 /Source="Nicolas_S_feature" /locus_tag="new_846186_849552" /HighExp="Salt, Sw, Etha, LoTm, B36, Heat, LPhT, BC, T0.30H, H2O2" /AntisenseName="yfkR" /AntisenseCor="-1.3937740774571999E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.952" /label="S272" CDS complement(749444..749644) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative spore germination D protein" /protein_id="NP_388658.1" /db_xref="EnsemblGenomes-Gn:BSU07770" /db_xref="EnsemblGenomes-Tr:CAB12606" /db_xref="GOA:O35036" /db_xref="SubtiList:BG12934" /db_xref="UniProtKB/Swiss-Prot:O35036" /translation="MISYIVQTLIVCIAIYAYEWKNFRSANNLTKWAFSLLIAGSAFL WIYMRVNPLLPRLGHLFKYIPF*" /label="yfkS CDS" gene complement(749444..749644) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /label="yfkS gene" CDS complement(749660..750814) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388659.1" /db_xref="EnsemblGenomes-Gn:BSU07780" /db_xref="EnsemblGenomes-Tr:CAB12607" /db_xref="GOA:O35028" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG12933" /db_xref="UniProtKB/Swiss-Prot:O35028" /translation="MKKTIYKCVLPLLICILLTGCWDRTEINDIAFVVSSAIDKKKDQ YRVAMQIPLVGQLGGQTGGGGGTAGSKTWYVDSASGTTIREANNKLQTSLSRTINTSH RRTVIIGEDMARDGVAPVFDILTRNPQNRLTALILVSRGEARDILNTDVQLEQFPAEM IRELAIIATSRPVFLSRFMSDLVEIGSDPYAPVISASKTKPGGKGKSNLKIDGLAIFK KDRLMDIFKDEHMTAALMLLNQARQPEFIVDLPNQMGQASIQLQKSNASFHAAEKNGK LSMTIEIRAKGIIMENQSTYETRENDQYYIIQKALNRTIKKDVISTVHRLQKLKADPA GFQDRTIRSTATTKNLLKKEWEEVYKDMEVHVVPIVTIEQGGVLYKTISH*" /label="yfkR CDS" gene complement(749660..750814) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /label="yfkR gene" CDS complement(750795..752336) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388660.1" /db_xref="EnsemblGenomes-Gn:BSU07790" /db_xref="EnsemblGenomes-Tr:CAB12608" /db_xref="GOA:O34486" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG12932" /db_xref="UniProtKB/Swiss-Prot:O34486" /translation="MNKRDKALQLIKELEDNQDRPISPNLKENLENLTLLTEGCSDIV FRQFDFGNGLCGFIVYIEGIVKSEHIQDHALRPFLMHLTDQIDEHEEALQNTLSISSV ALETSMSKVAASIIEGNAVLFADGHSKGLILNIKGGQRRSIEEPITESTIRGSREGFT ESLRVNTALVRFRVKTFQLKMISFKIGTKTKTDVVLAYIDGLADPKVIDKAKKRIKKI KIDAVLESGYIEEFIEDDTYSPFPQLQYTERPDTVAAQLLEGRFAIFTDNTPFVLTGP ITFWQLMQASEDYYERYLMSNLIRWLRYMFLFVALYLPAIYVAVITYHQDLMPTNLMF SVASAREPIPFPAIIEALIMEISFEALREAGVRLPKTIGQTVSILGALVIGTAAVEAG IVSAPMVIIVSLTGIASFTIPRFNLAISIRMLRFPLMFLASIFGIFGIMLGTIILVLH LCKLQSFGIPYLSGISPFKRDEVKDIFVRAPWWTMTRRPGTYSRGNGQKGAKREDPKD EENNI*" /label="yfkQ CDS" gene complement(750795..752336) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /label="yfkQ gene" promotor_-10 complement(752386..752397) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(752389) /Source="Nicolas_upshifts" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(752411..752417) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 752446..752453 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 752468..752487 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 752475 /Source="Nicolas_upshifts" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(752521) /Source="Nicolas_upshifts" /id="D386" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="1.35091" /MaxDrop="3.57201" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U596" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 752529..753941 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /EC_number="2.7.1.201" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 8755887, 8917076, 8969503, 18977770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 8755887, 8917076, 8969503, 18977770; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) trehalose-specific enzyme IIBC component" /protein_id="NP_388661.1" /db_xref="EnsemblGenomes-Gn:BSU07800" /db_xref="EnsemblGenomes-Tr:CAB12609" /db_xref="GOA:P39794" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011296" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11009" /db_xref="UniProtKB/Swiss-Prot:P39794" /translation="MGELNKSARQIVEAVGGAENIAAATHCVTRLRFALIDESKVDQE MLDQIDVVKGSFSTNGQFQVVIGQGTVNKVYAELVKETGIGESTKDEVKKASEKNMNP LQRAVKTLADIFIPILPAIVTAGLLMGINNILTAEGIFFSTKSIVQVYPQWADLANMI NLIAGTAFTFLPALIGWSAVKRFGGNPLLGIVLGVMLVHPDLLNAWGYGAAEQSGEIP VWNLFGLEVQKVGYQGQVLPILLASYMLAKIEVFLTKRTPEGIQLLVVAPITLLLTGF ASFIIIGPITFAIGNVLTSGLISVFGSFAALGGLLYGGFYSALVITGMHHTFLAVDLQ LIGSKLGGTFLWPMLALSNIAQGSAALAMMFIVKDEKQKGLSLTSGISAYLGITEPAI FGVNLRYRFPFIIAMVSSGLAGMYISSQGVLASSVGVGGVPGIFSIMSQYWGAFAIGM AIVLIVPFAGTYAYARFKHK*" /label="treP CDS" gene 752529..753941 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /label="treP gene" promotor_no_box complement(752547..752647) /Source="Nicolas_upshift_promotors" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(752587) /Source="Nicolas_upshifts" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 754012..755697 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /EC_number="3.2.1.93" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651129, 7751281, 8755887, 8917076, 9701821, 26894535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651129, 7751281, 8755887, 8917076, 9701821, 26894535; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="trehalose-6-phosphate hydrolase" /protein_id="NP_388662.1" /db_xref="EnsemblGenomes-Gn:BSU07810" /db_xref="EnsemblGenomes-Tr:CAB12610" /db_xref="GOA:P39795" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR012769" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG11010" /db_xref="UniProtKB/Swiss-Prot:P39795" /translation="MKTEQTPWWKKAVVYQIYPKSFNDTTGNGVGDLNGIIEKLDYLK TLQVDVLWLTPIYDSPQHDNGYDIRDYYSIYPEYGTMEDFERLVSEAHKRDLKVVMDL VVNHTSTEHKWFREAISSIDSPYRDFYIWKKPQENGSVPTNWESKFGGSAWELDEASG QYYLHLFDVTQADLNWENEEVRKHVYDMMHFWFEKGIDGFRLDVINLISKDQRFPNAE EGDGRSFYTDGPRVHEFLHEMNEKVFSHYDSMTVGEMSSTTVDHCIRYTNPDNKELDM TFSFHHLKVDYPNGEKWALAPFDFLKLKEILSDWQTGMHAGGGWNALFWCNHDQPRVV SRYGDDGAYRVKSAKMLATAIHMMQGTPYIYQGEELGMTNPKFTDISSYRDVESLNMY HAFKEKGMADQDITAILQAKSRDNSRTPVQWDATENGGFTTGTPWIPVAGNYREINAE AALRDQNSVFYHYQKLIQIRKMYDIVTEGTYEIIAKDDPNIFAYLRHGSNEKLLVINN FYGTEAAFTLPDSLAPDEWKAEVLLTNDEAREGLQNMTLRPYESIVYRLTKPC*" /label="treA CDS" gene 754012..755697 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /label="treA gene" promotor_-10 complement(754318..754333) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(754325) /Source="Nicolas_upshifts" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(754346..754355) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 755670..755674 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 755690..755709 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 755693 /Source="Nicolas_upshifts" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 755718..756434 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755887, 9829827, 17705272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755887, 9829827, 17705272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TreR-trehalose)" /protein_id="NP_388663.1" /db_xref="EnsemblGenomes-Gn:BSU07820" /db_xref="EnsemblGenomes-Tr:CAB12611" /db_xref="GOA:P39796" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR012770" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OGG" /db_xref="SubtiList:BG11011" /db_xref="UniProtKB/Swiss-Prot:P39796" /translation="MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRET VRKALHMLAQNGYIQKIRGKGSVVLNREKMQFPVSGLVSFKELAQTLGKETKTTVHKF GLEPPSELIQKQLRANLDDDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENS IYEYIEGELGLSISYAQKEIVAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQY TESRHRLDKFRFVDFARRGK*" /label="treR CDS" gene 755718..756434 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /label="treR gene" downshifts 756427 /Source="Nicolas_upshifts" /id="D387" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="6.58905" /MaxDrop="4.05981" /score="24.6748216" /energy="-11.1" /TU="U595,U598" /idTUdmin="U595" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" promotor_-35 756509..756512 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 756528..756547 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 756537 /Source="Nicolas_upshifts" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 756574..757239 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /EC_number="1.5.1.39" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15252706, 20727918, 20862523, 22238377, 26415543" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 20727918, 20862523, 22238377, 26415543; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H-flavin oxidoreductase (nitroreductase)" /protein_id="NP_388664.1" /db_xref="EnsemblGenomes-Gn:BSU07830" /db_xref="EnsemblGenomes-Tr:CAB12612" /db_xref="GOA:O34475" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="InterPro:IPR033878" /db_xref="SubtiList:BG12931" /db_xref="UniProtKB/Swiss-Prot:O34475" /translation="MADLKTQILDAYNFRHATKEFDPNKKVSDSDFEFILETGRLSPS SLGLEPWKFVVVQNPEFREKLREYTWGAQKQLPTASHFVLILARTAKDIKYNADYIKR HLKEVKQMPQDVYEGYLSKTEEFQKNDLHLLESDRTLFDWASKQTYIALGNMMTAAAQ IGVDSCPIEGFQYDHIHRILEEEGLLENGSFDISVMVAFGYRVRDPRPKTRSAVEDVV KWV*" /label="hypO CDS" gene 756574..757239 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /label="hypO gene" downshifts 757220 /Source="Nicolas_upshifts" /id="D388" /incds=0 /nref=180 /ntot=269 /MaxReadThrough="0.70079" /MaxDrop="6.77615" /score="34.5750428" /energy="-16.9" /TU="NA" /idTUdmin="U595" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(757276..761664) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /EC_number="3.1.4.16" /EC_number="3.1.3.5" /EC_number="3.1.3.6" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14688230, 16291680, 21800427, 21906378, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported 2',3'-cyclic-nucleotide 2'-phosphodiesterase, 2' (or 3') nucleotidase and 5' nucleotidase" /protein_id="NP_388665.1" /db_xref="EnsemblGenomes-Gn:BSU07840" /db_xref="EnsemblGenomes-Tr:CAB12613" /db_xref="GOA:O34313" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="PDB:3GVE" /db_xref="SubtiList:BG12930" /db_xref="UniProtKB/Swiss-Prot:O34313" /translation="MRIQKRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQVH LSILATTDIHANMMDYDYYSDKETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGN PLGEYAVKYQKDDIISGTKTHPIISVMNALKYDAGTLGNHEFNYGLDFLDGTIKGADF PIVNANVKTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLEG QVQVQDIVESANETIPKMKAEGADVIIALAHTGIEKQAQSSGAENAVFDLATKTKGID AIISGHQHGLFPSAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKLEKADGSW KVADSKGSIESIAGNVTSRNETVTNTIQQTHQNTLEYVRKPVGKTEADINSFFAQVKD DPSIQIVTDAQKWYAEKEMKDTEYKNLPILSAGAPFKAGGRNGANYYTNIPAGDLAIK NVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNENFRSYNFDV IDGVTYQVDVTKPAKYNENGKVINADSSRIINLSYEGKPISPSQEFLVVTNNYRASGG GGFPHLTSDKIVHGSAVENRQVLMDYIIEQKTVNPKADNNWSIAPVSGTNLTFESSLL AKPFADKADDVAYVGKSANEGYGVYKLQFDDDSNPDPPKDGLWDLTVMHTNDTHAHLD DAARRMTKINEVRSETNHNILLDAGDVFSGDLYFTKWNGLADLKMMNMMGYDAMTFGN HEFDKGPTVLSDFLSGNSATVDPANRYHFEAPEFPIVSANVDVSNEPKLKSFVKKPQT FTAGEKKEAGIHPYILLDVDGEKVAVFGLTTEDTATTSSPGKSIVFNDAFETAQNTVK AIQEEEKVNKIIALTHIGHNRDLELAKKVKGIDLIIGGHTHTLVDKMEVVNNEEPTIV AQAKEYGQFLGRVDVAFDEKGVVQTDKSNLSVLPIDEHTEENPEAKQELDQFKNELED VKNEKVGYTDVALDGQREHVRTKETNLGNFIADGMLAKAKEAAGARIAITNGGGIRAG IDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGLSNVENGGGAFPQVAGIEYT FTLNNKPGHRVLEVKIESPNGDKVAINTDDTYRVATNNFVGAGGDGYSVFTEASHGED LGYVDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDKFAIYAKNANT PFVYYGIHEGSQEKPINLKVKKDQVKLLKERESDPSLTMFNYWYSMKMPMANLKTADT AIGIKSTGELDVSLSDVYDFTVKQKGKEIKSFKEPVQLSLRMFDIEEAHNPAIYHVDR KKKAFTKTGHGSVDDDMVTGYTNHFSEYTILNSGSNNKPPAFPSDQPTGGDDGNHGGG SDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPDTATSMYSILL AGFLISALGTAMYLHQRRKQNRANQA*" /label="yfkN CDS" gene complement(757276..761664) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /label="yfkN gene" downshifts complement(757295) /Source="Nicolas_upshifts" /id="D389" /incds=0 /nref=155 /ntot=229 /MaxReadThrough="1.00159" /MaxDrop="7.08591" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(761697..761716) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(761714) /Source="Nicolas_upshifts" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(761731..761734) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 761841..761847 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 761861..761879 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 761864 /Source="Nicolas_upshifts" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 761907..762425 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="general stress protein 18; deglycase" /protein_id="NP_388666.1" /db_xref="EnsemblGenomes-Gn:BSU07850" /db_xref="EnsemblGenomes-Tr:CAB12614" /db_xref="GOA:P80876" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12929" /db_xref="UniProtKB/Swiss-Prot:P80876" /translation="MGKKIAVVLTYYFEDSEYTEPAKAFKEAGHELTVIEKEKGKTVK GKQGTAEVTVDASIDDVNSSDFDALLIPGGFSPDQLRADDRFVQFTKAFMTDKKPVFA ICHGPQLLINAKALDGRKATGYTSIRVDMENAGADVVDKEVVVCQDQLVTSRTPDDIP AFNRESLALLEK*" /label="sufLB CDS" gene 761907..762425 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /label="sufLB gene" downshifts 762411 /Source="Nicolas_upshifts" /id="D390" /incds=0 /nref=35 /ntot=153 /MaxReadThrough="8.02255" /MaxDrop="6.97573" /score="42.2080398" /energy="-12.9" /TU="U601" /idTUdmin="U601" /TUdmin="-3542" /isTUend="FALSE" /label="downshifts" downshifts complement(762455) /Source="Nicolas_upshifts" /id="D391" /incds=0 /nref=22 /ntot=199 /MaxReadThrough="1.59285" /MaxDrop="3.61098" /score="31.1923457" /energy="-11.1" /TU="NA" /idTUdmin="U602" /TUdmin=10 /isTUend="TRUE" /label="downshifts" S_feature 762456..764106 /Source="Nicolas_S_feature" /locus_tag="new_860294_861944" /HighExp="Etha, S6, S8, S5, S7, Gly, Salt, LoTm, S4, Diami" /AntisenseName="yfkL" /AntisenseCor="-0.52109661167911703" /AntisenseRegPval="-19.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S273" CDS complement(762465..763655) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16828913, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter" /protein_id="NP_388667.1" /db_xref="EnsemblGenomes-Gn:BSU07860" /db_xref="EnsemblGenomes-Tr:CAB12615" /db_xref="GOA:O34597" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12928" /db_xref="UniProtKB/Swiss-Prot:O34597" /translation="MQTTSIKTASGMYINYFFLGMVNIILASNMSSLTKQWNTDPTGI SYVIAAIGFGKLLTYGISGVLSDKIGRKPLVVASAGIMAVFLVGIPLSPSYELAFVFA LLAGVANSAMDAGTYPALTELFPSASGSANVLVKAFMSVGAALLPLLITFLADHSMFY GFAFYLPAAVYLLNIIYLSTLSFPKKHKKPTNSGQQESPVFLSEPVFQKEGTALIIIG FTSTALFTVSQIWLPSYAQKAAGLAESASVQLLSYYSIGSLASVLLLAVLLNRWVKPV FITLLYPIITLCTLAVMLTVHIPVVLDITAFFLGFSTAGVFQITITLMTELFWKRKGT VTGIVATASSLASILLPIATGLIAKAGGIAHIFIFDFGIAVIGTAAAAFLYYRYKKLT GAQA*" /label="yfkL CDS" gene complement(762465..763655) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /label="yfkL gene" S_feature complement(763656..763747) /Source="Nicolas_S_feature" /locus_tag="new_861494_861585_c" /HighExp="C90, MG 10, BMM, MG-0.2, MG t5, MG 5, MG-0.1, UNK1, HPh, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S274" CDS complement(763748..763963) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388668.1" /db_xref="EnsemblGenomes-Gn:BSU07870" /db_xref="EnsemblGenomes-Tr:CAB12616" /db_xref="InterPro:IPR009507" /db_xref="SubtiList:BG12927" /db_xref="UniProtKB/Swiss-Prot:O35019" /translation="MSSPNTETLTQMIEEISQKLNMLNVGVIKAEDFSDEKIEDLTYL HRMVMKKESFSPSEMQAIAQELASLRK*" /label="yfkK CDS" gene complement(763748..763963) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /label="yfkK gene" downshifts complement(763807) /Source="Nicolas_upshifts" /id="D392" /incds=0 /nref=1 /ntot=131 /MaxReadThrough="3.65318" /MaxDrop="2.45155" /score="16.183887" /energy="-11.6" /TU="U602" /idTUdmin="U602" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(763995..764014) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(764009) /Source="Nicolas_upshifts" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(764029..764030) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 764076..764083 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 764098..764117 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 764108 /Source="Nicolas_upshifts" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 764166..764636 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /EC_number="3.1.3.48" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-tyrosine-phosphatase" /protein_id="NP_388669.1" /db_xref="EnsemblGenomes-Gn:BSU07880" /db_xref="EnsemblGenomes-Tr:CAB12617" /db_xref="GOA:O35016" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:4ETM" /db_xref="SubtiList:BG12926" /db_xref="UniProtKB/Swiss-Prot:O35016" /translation="MISVLFVCLGNICRSPMAEAIFRDLAAKKGLEGKIKADSAGIGG WHIGNPPHEGTQEILRREGISFDGMLARQVSEQDLDDFDYIIAMDAENIGSLRSMAGF KNTSHIKRLLDYVEDSDLADVPDPYYTGNFEEVCQLIKTGCEQLLASIQKEKQL*" /label="yfkJ CDS" gene 764166..764636 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /label="yfkJ gene" CDS 764654..764974 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388670.1" /db_xref="EnsemblGenomes-Gn:BSU07890" /db_xref="EnsemblGenomes-Tr:CAB12618" /db_xref="SubtiList:BG12925" /db_xref="UniProtKB/Swiss-Prot:O34418" /translation="MNNERLMLKGIFLGAAAGAALSLLHKPTRQACGMRWLTCKHKLS LYKSNPELLKNTVITKVDEAKKLARTLSKEVDFVNQQVKELKKTTPQVMELVQETKEH FSKK*" /label="yfkI CDS" gene 764654..764974 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /label="yfkI gene" CDS 764998..765825 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222749, 12794188, 15849754, 16850406, 15764599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease BN" /protein_id="NP_388671.1" /db_xref="EnsemblGenomes-Gn:BSU07900" /db_xref="EnsemblGenomes-Tr:CAB12619" /db_xref="GOA:O34437" /db_xref="InterPro:IPR017039" /db_xref="SubtiList:BG12924" /db_xref="UniProtKB/Swiss-Prot:O34437" /translation="MSFLKELFSRYTLHEGQSKSAELAYFFLLSLFPFLIFMLTLTAY LPLSTDDVLGVIEQYAPASAMSLVESITHQTLNNRNGGLLSFGIIAALWSASNGMNAI VRSLNHAYDVEENRSFIIVRLTSIFLTIAMVFTILVALLLPVFGREIGRLASDFVGAS DLFLSVWAAIRWGVSPLVLLIVFSALYVIAPNKKLSLRFVMPGAVFATIGWIIVSTLF SFYVSTFANYSATYGSIGGIIVLMIWFYLSGILIILGGEINALLHKRKKLPDENPYH* " /label="rbn CDS" gene 764998..765825 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /label="rbn gene" promotor_-35 765804..765810 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 765825..765836 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 765843..765999 /Source="Nicolas_S_feature" /locus_tag="new_863681_863837" /HighExp="S8, Etha, S6, Salt, S7, S5, ferm, nit, BT, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99976299999999996" /TUshortSig="SigGF, SigA, SigB" /TUshortPSig="0.974, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S275" upshifts 765843 /Source="Nicolas_upshifts" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(765875) /Source="Nicolas_upshifts" /id="D393" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.22239" /MaxDrop="3.61507" /score="-5.45682213" /energy="-3" /TU="NA" /idTUdmin="U606" /TUdmin=440 /isTUend="FALSE" /label="downshifts" downshifts 765974 /Source="Nicolas_upshifts" /id="D394" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="1.4253" /MaxDrop="6.85849" /score="25.8200126" /energy="-17.9" /TU="NA" /idTUdmin="U603" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(766024..767199) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388672.1" /db_xref="EnsemblGenomes-Gn:BSU07910" /db_xref="EnsemblGenomes-Tr:CAB12620" /db_xref="GOA:O34929" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12923" /db_xref="UniProtKB/Swiss-Prot:O34929" /translation="MSRFHFFILVLLVSISGFSQGMLLPVISIIFETNGESAAINGLH ATGLYIGVLLASPFMEAPLRKLGFKPLIVMGGSIVILSLFGFIWLQSVWVWFLLRLFI GIGDHMLHFSTQTWVTSMSSKQNRGRNLSIYGLSFGLGFAAGPFMVPLVKLSPSLPFI VSGCISLFAWLFVFFLQNAYPETSPHETKSDNSFRRFYQAMLFGWVAFMPTFGYGFLE TALNGSFPVYALRLGISVDAVAIILPAFAIGSIIFQFPLGILSDKYGRRNVLLVILLT GALCFFIAGVFPSPYVIGGCFFIAGMAVGSTFTLGISYMTDLLPPHLLPAGNLLCGIT FSLGSILGPVAGGWYMQTFESANLFYFITLTLSSVWLALVLGKPKSWSPAETYSSSS* " /label="yfkF CDS" gene complement(766024..767199) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /label="yfkF gene" downshifts complement(766029) /Source="Nicolas_upshifts" /id="D395" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="0.37084" /MaxDrop="3.28031" /score="3.2266059" /energy="-14.1" /TU="NA" /idTUdmin="U606" /TUdmin=286 /isTUend="FALSE" /label="downshifts" promotor_-35 766636..766642 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 766658..766676 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 766662..767315 /Source="Nicolas_S_feature" /locus_tag="new_864500_865153" /HighExp="Etha, M9-stat, Salt, Sw, Gly, B60, Heat, LPhT, HiTm, T0.30H" /AntisenseName="yfkF" /AntisenseCor="-0.18505347560608301" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S276" upshifts 766662 /Source="Nicolas_upshifts" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(767224..767243) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(767239) /Source="Nicolas_upshifts" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(767257..767264) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 767305..767310 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 767317 /Source="Nicolas_upshifts" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 767325..767343 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 767367..768422 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19543710, 23798403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19543710, 23798403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+/Ca2+ antiporter" /protein_id="NP_388673.1" /db_xref="EnsemblGenomes-Gn:BSU07920" /db_xref="EnsemblGenomes-Tr:CAB12621" /db_xref="GOA:O34840" /db_xref="InterPro:IPR004713" /db_xref="InterPro:IPR004798" /db_xref="InterPro:IPR004837" /db_xref="PDB:4KJR" /db_xref="PDB:4KJS" /db_xref="SubtiList:BG12922" /db_xref="UniProtKB/Swiss-Prot:O34840" /translation="MNRIFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYM GRATESLSIIAGPRIGGLLNATFGNAVELIISLFALKEGLTGIVLASLTGSVLGNLLL VAGLSFFVGGLKYKRQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSI GISIIMILLYVAALYFKLVTHRGVYQPNNAAQTEEEEEPEWSGKVATIVLFAATIVVA YISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAV GSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEG ATLLAAYVIMAIGFFLL*" /label="chaA CDS" gene 767367..768422 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /label="chaA gene" promotor_-35 768436..768442 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 768457..768468 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 768461 /Source="Nicolas_upshifts" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="upshifts" CDS 768493..769287 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19543710" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388674.1" /db_xref="EnsemblGenomes-Gn:BSU07930" /db_xref="EnsemblGenomes-Tr:CAB12622" /db_xref="InterPro:IPR025548" /db_xref="SubtiList:BG12921" /db_xref="UniProtKB/Swiss-Prot:O34579" /translation="MMKKLFHSTLIVLLFFSFFGVQPIHAKKQFKVPNSVASISKENT YPNASQDQPMLQPSKLAKELLDHSEVKIENPHLIKMLNESNISGTPLAVGYRATIFLG KWALGYESNETVANWEYKKINTNRADNRGGKETAEMHYAQEQQYRVKGGLTAKVPNAE DVKSMMMQKAMKKTNLPLAFETVIGAGTKRDQIYKVAPKKIGYLHAYAPAVNEKGKVT YGEVYLVLKGNKRKLVVKNVTSQGIGAWIPVQDHVTFGFQLSSLPR*" /label="yfkD CDS" gene 768493..769287 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /label="yfkD gene" downshifts 769275 /Source="Nicolas_upshifts" /id="D396" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="0.82657" /MaxDrop="5.7252" /score="28.7014976" /energy="-9.5" /TU="NA" /idTUdmin="U605" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(769326..770168) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17665170, 18310427, 19252899; Product type t: transporter" /codon_start=1 /transl_table=11 /product="mechanosensitive ion channel" /protein_id="NP_388675.1" /db_xref="EnsemblGenomes-Gn:BSU07940" /db_xref="EnsemblGenomes-Tr:CAB12623" /db_xref="GOA:O35043" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="SubtiList:BG12920" /db_xref="UniProtKB/Swiss-Prot:O35043" /translation="MRMKETLTEIFQNKIVDILLVAVILWIGVFIINRLVQLFFKRTD FIEEKKEKTIESLVRSVTQYTATIGFIFYVISLFVHDFGKILAGAGVAGIVIGFGAQS LIKDVLAGVFLIYERQLHKGDYVTVNNLFNGTVEEIGLRSLQIREWSGKLLTISNGEV RQIENYNIDFMRITESFLISFKEDPDRVYSVLEEACDMLNEELRDSLKRDEFGNPTEP FQIHGITALNKINRGVEFTVKGMVKDDDYFSASLAVRRVLVRQLYQNNVQMLEEAVRI ERTQ*" /label="mscC CDS" gene complement(769326..770168) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /label="mscC gene" downshifts complement(769328) /Source="Nicolas_upshifts" /id="D397" /incds=0 /nref=58 /ntot=230 /MaxReadThrough="1.96922" /MaxDrop="4.8789" /score="23.5281308" /energy="-9.8" /TU="NA" /idTUdmin="U609" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(770169..771290) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative Fe-S oxidoreductase, radical SAM superfamily" /protein_id="NP_388677.2" /db_xref="EnsemblGenomes-Gn:BSU07955" /db_xref="EnsemblGenomes-Tr:CAB12625" /db_xref="GOA:O34400" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014866" /db_xref="InterPro:IPR031004" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG12918" /db_xref="UniProtKB/Swiss-Prot:O34400" /translation="MTQNTKLRPITPEFDPWEAYMDVDQYGDMQLTNVEFTTTTLCNM RCEHCAVGYTLQPKDPNALPIDLLLKRLEEIPRLRSISITGGEPMLSLKSVKEYVVPL LKYAHERGVRTQINSNLTLDIERYEWIIPYLDVLHISHNWGTVEDFAEIGFAMMDRKP TFEQRARYFEKMIENSRTLVDAGVMVSAETMLNKRTLPHIEHIHRQITEDMKCQRHEV HPMYPSDFASALESLSLKEMRQAIHRLLDIRDENTWMLFGTLPFYACSPDEDDQKLLR RLRAAKNVTVRNDPDGRSRLNVNIFDGNIIVTDFGDTPPLGNIQTDSLPSAYEKWRET KLAKELSCHCPNVRCLGPNVLVKNSYYQDTDFTKRQARS*" /label="yfkA CDS" gene complement(770169..771290) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /label="yfkA gene" promotor_-10 complement(771331..771350) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(771349) /Source="Nicolas_upshifts" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(771366..771370) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 771378..771385 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 771399..771418 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 771409 /Source="Nicolas_upshifts" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="upshifts" CDS 771435..771620 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388678.1" /db_xref="EnsemblGenomes-Gn:BSU07970" /db_xref="EnsemblGenomes-Tr:CAB12626" /db_xref="SubtiList:BG12916" /db_xref="UniProtKB/Swiss-Prot:O35041" /translation="MGNAVNNKDQQIDYLKNRLDMFMNVIDSLDPEATDVEDIDRLIS MLDDLEAKYERFKKDWE*" /label="yfjT CDS" gene 771435..771620 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /label="yfjT gene" downshifts 771599 /Source="Nicolas_upshifts" /id="D398" /incds=0 /nref=15 /ntot=177 /MaxReadThrough="3.03457" /MaxDrop="3.24661" /score="14.1645187" /energy="-6.4" /TU="U610" /idTUdmin="U610" /TUdmin="-559" /isTUend="FALSE" /label="downshifts" promotor_-35 771663..771669 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 771675 /Source="Nicolas_upshifts" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 771684..771695 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 771721..772512 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported peptidoglycan N-acetylmuramic acid deacetylase" /protein_id="NP_388679.1" /db_xref="EnsemblGenomes-Gn:BSU07980" /db_xref="EnsemblGenomes-Tr:CAB12627" /db_xref="GOA:O34928" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014235" /db_xref="PDB:1NY1" /db_xref="PDB:1W17" /db_xref="PDB:1W1A" /db_xref="PDB:1W1B" /db_xref="SubtiList:BG12915" /db_xref="UniProtKB/Swiss-Prot:O34928" /translation="MKWMCSICCAAVLLAGGAAQAEAVPNEPINWGFKRSVNHQPPDA GKQLNSLIEKYDAFYLGNTKEKTIYLTFDNGYENGYTPKVLDVLKKHRVTGTFFVTGH FVKDQPQLIKRMSDEGHIIGNHSFHHPDLTTKTADQIQDELDSVNEEVYKITGKQDNL YLRPPRGVFSEYVLKETKRLGYQTVFWSVAFVDWKINNQKGKKYAYDHMIKQAHPGAI YLLHTVSRDNAEALDDAITDLKKQGYTFKSIDDLMFEKEMRLPSL*" /label="pdaA CDS" gene 771721..772512 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /label="pdaA gene" downshifts 772510 /Source="Nicolas_upshifts" /id="D399" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.12067" /MaxDrop="3.4013" /score="14.4741934" /energy="-10.2" /TU="NA" /idTUdmin="U611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(772550..773410) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative beta-hydroxyacid dehydrogenase" /protein_id="NP_388680.2" /db_xref="EnsemblGenomes-Gn:BSU07990" /db_xref="EnsemblGenomes-Tr:CAB12628" /db_xref="GOA:O34969" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12914" /db_xref="UniProtKB/Swiss-Prot:O34969" /translation="MKIAVIGLGNMGQPIARNVLQAGYELTVYNRTKQKTEDLVTEGA QAADTPRLAAKSADIVITMLADDDSVSTVTFGEDGLLEGLAENGIHISMSTISVEFSE KLAAAHAEKGQFFLAAPVLGRPDAAAKAALRIITAGPAEAKQAAKPLLDSLSQQIFDV GEESKTANAAKISINFLLVSMLEALSESFLMMEKYGLEQKQFLEIASALFGSPVYQNY GTIMAEQKFEPAGFKMSLGLKDTNLALAAAKRVSANLPLAELAKSHFESGIEKGFGDL DWAALIKCIK*" /label="yfjR CDS" gene complement(772550..773410) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /label="yfjR gene" downshifts complement(772564) /Source="Nicolas_upshifts" /id="D400" /incds=0 /nref=15 /ntot=193 /MaxReadThrough="2.61589" /MaxDrop="3.98341" /score="-1.3382901" /energy="-12.1" /TU="NA" /idTUdmin="U612" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(773430..773449) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(773444) /Source="Nicolas_upshifts" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(773465..773468) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(773509..774468) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563871, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="divalent cation (octahedral coordination) transporter" /protein_id="NP_388681.1" /db_xref="EnsemblGenomes-Gn:BSU08000" /db_xref="EnsemblGenomes-Tr:CAB12629" /db_xref="GOA:O31543" /db_xref="InterPro:IPR002523" /db_xref="InterPro:IPR004488" /db_xref="SubtiList:BG12913" /db_xref="UniProtKB/Swiss-Prot:O31543" /translation="MINITAITTEHQLLKNIPIERVEQPDIAWYWVDFYGPEDTETAL LRDFFHFHPLAIEDCFQHMQRPKLDHYDGYRFYVIHALNKETLETEEVDIFQGEKFVV TFHLHETPGIAKVRERLYASPDILKKGPGHISYMIMDQLVDEYFPLVYKIEDRLNEIE ESRPHKTYGTLMNEVFDLRTDLLHLRRTIIPMRDLLYRILSLDHVKEQRETKAYFSDI YDHLLKLSEIVESNRDMTSDLRDSYVTLNSNRMNAIMMTLTIVSTIFIPLTFIAGVYG MNFDFMPELHWKYGYFAVLGLMAALVIGMLIWFVHKGWFNIFK*" /label="yfjQ CDS" gene complement(773509..774468) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /label="yfjQ gene" downshifts complement(773532) /Source="Nicolas_upshifts" /id="D401" /incds=0 /nref=137 /ntot=224 /MaxReadThrough="2.29296" /MaxDrop="4.2496" /score="10.2736001" /energy="-7.5" /TU="NA" /idTUdmin="U613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(774479..774498) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(774482) /Source="Nicolas_upshifts" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(774514..774517) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 774529..774533 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 774547..774566 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 774556 /Source="Nicolas_upshifts" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="upshifts" CDS 774587..775450 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /EC_number="3.2.2.21" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA-3-methyladenine glycosylase" /protein_id="NP_388682.1" /db_xref="EnsemblGenomes-Gn:BSU08010" /db_xref="EnsemblGenomes-Tr:CAB12630" /db_xref="GOA:O31544" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG12912" /db_xref="UniProtKB/Swiss-Prot:O31544" /translation="MWKEKVSVTPPYHFDRVLDRLSLDPLNAVDREAREVRVPIRNQA GDVCIVKVQALGHAGEPEFLVSGETDQGEMMKEIKRIFQWENHLQHVLDHFSKTSLSA IFEEHAGTPLVLDYSVYNCMMKCIIHQQLNLSFAYTLTERFVHAFGEQKDGVWCYPKP ETIAELDYQDLRDLQFSMRKAEYTIDTSRMIAEGTLSLSELPHMADEDIMKKLIKIRG IGPWTVQNVLMFGLGRPNLFPLADIGLQNAIKRHFQLDDKPAKDVMLAMSKEWEPYLS YASLYLWRSIE*" /label="yfjP CDS" gene 774587..775450 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /label="yfjP gene" S_feature 775451..775563 /Source="Nicolas_S_feature" /locus_tag="new_873289_873401" /HighExp="BC, M40t90, LBGtran, C90, M9-stat, M0t90, Lbtran, Sw, M40t45, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S277" CDS 775564..776964 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methyltransferase" /protein_id="NP_388683.1" /db_xref="EnsemblGenomes-Gn:BSU08020" /db_xref="EnsemblGenomes-Tr:CAB12631" /db_xref="GOA:O31545" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12911" /db_xref="UniProtKB/Swiss-Prot:O31545" /translation="MNQQKKQAPVELKVGQTFPLTIKRLGINGEGVGYFKKKVVFVPG ALPGEEVVVQATKVQPKFSEGRIKKIRKASEHRVAPPCPVYEQCGGCQLQHLAYSQQL REKRDIVIQSLERHTKFKVENMEIKETIGMDNPWNYRNKSQFQIGRSQSGSIIAGLYG LDSHDIVPIKDCIVQHPATNKTTGIVRRILEDFNVSVYNERKRKGDVRTIVTRVGFET GEVQVVLVTAKETLPHKEEIVKAIQKRLPEVKSIIQNVNGAKTSVIFGEKTKQLAGKT VIQEVLGDVSFELSARAFFQLNPEQTVKLYDEVKKAAQLTGKEKVVDAYCGVGTIGMW VADGAKEVRGMDVIKESIDDAKKNAKKHGMANATYVTGTAEHWLPKWTKEGFRPDVVI VDPPRTGCDSTFLDTIKKVKPKRFVYVSCNPSTLAKDLQTLSKDYRVDYIQPVDMFPQ TAHVEAVARLVLKSSN*" /label="yfjO CDS" gene 775564..776964 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /label="yfjO gene" downshifts 776976 /Source="Nicolas_upshifts" /id="D402" /incds=0 /nref=198 /ntot=251 /MaxReadThrough="1.18186" /MaxDrop="5.19313" /score="11.8630961" /energy="-12.6" /TU="NA" /idTUdmin="U614" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 777270..777277 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 777293..777312 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 777299 /Source="Nicolas_upshifts" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="upshifts" S_feature 777306..777589 /Source="Nicolas_S_feature" /locus_tag="new_875144_875427" /HighExp="M9-stat, T1.30H, T0.30H, T2.0H, LoTm, T3.0H, T3.30H, T1.0H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69102300000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S278" CDS 777590..777856 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097694.1" /db_xref="EnsemblGenomes-Gn:BSU08029" /db_xref="EnsemblGenomes-Tr:CAX52581" /db_xref="GOA:C0H3X6" /db_xref="InterPro:IPR025627" /db_xref="UniProtKB/Swiss-Prot:C0H3X6" /translation="MDKVYKRSWFQTFLAFLVSQLYFNFVELTGWGPKYREMNGFPAN IVELDFFQTYLSFYDNPWFNIITVFLGVFTIIQIITGITKDIRN*" /label="yfzA CDS" gene 777590..777856 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /label="yfzA gene" promotor_-10 complement(777804..777823) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(777822) /Source="Nicolas_upshifts" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(777838..777841) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 777857..778338 /Source="Nicolas_S_feature" /locus_tag="new_875695_876176" /HighExp="G180, Paraq, H2O2, G135, Oxctl, G150, C30, LoTm, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S279" promotor_-35 778309..778312 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 778329..778348 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 778340..778587 /Source="Nicolas_S_feature" /locus_tag="new_876178_876425" /HighExp="H2O2, G180, Paraq, G150, G135, Oxctl, dia15, LBGstat, LBGexp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S280" upshifts 778340 /Source="Nicolas_upshifts" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 778588..779565 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /EC_number="1.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 25902496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase 2" /protein_id="NP_388684.1" /db_xref="EnsemblGenomes-Gn:BSU08030" /db_xref="EnsemblGenomes-Tr:CAB12632" /db_xref="GOA:O31546" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG12910" /db_xref="UniProtKB/Swiss-Prot:O31546" /translation="MTENFWRELPRPFFVLAPMEDVTDVVFRHVVSEAGRPDVFFTEF TNSESYCHPDGKDSVRGRLTFTEDEQPIVAHIWGDKPENFRKMSIGMAELGFKGLDIN MGCPVPNVAGNGKGSGLICRPAVAAELIQAAKAGGLPVSVKTRLGYTDVDEWREWLTH ILKQDIANLSIHLRTRAEMSKVDAHWELIPEIKKLRDEVAPDTLLTINGDIPDRQTGL KLAEQYGVDGIMIGRGIFTNPFAFEKEPKEHSSKELLDLLRLHLDLHDEYSKEEARPY KPLPRFFKIYLRGFRGASELRNQCMNTKSTDEVRALLDDFERKYLDGIE*" /label="dusC CDS" gene 778588..779565 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /label="dusC gene" S_feature 779566..779658 /Source="Nicolas_S_feature" /locus_tag="new_877404_877496" /HighExp="G135, G180, Paraq, G150, H2O2, LBGexp, aero, dia0, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S281" downshifts 779615 /Source="Nicolas_upshifts" /id="D403" /incds=0 /nref=86 /ntot=218 /MaxReadThrough="3.30163" /MaxDrop="4.0519" /score="11.8630961" /energy="-12.6" /TU="U617" /idTUdmin="U618" /TUdmin="-1211" /isTUend="FALSE" /label="downshifts" promotor_-35 779699..779705 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 779717..779736 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 779726 /Source="Nicolas_upshifts" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 779761..780213 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388685.1" /db_xref="EnsemblGenomes-Gn:BSU08040" /db_xref="EnsemblGenomes-Tr:CAB12633" /db_xref="SubtiList:BG12909" /db_xref="UniProtKB/Swiss-Prot:O31547" /translation="MKRLCIIPCGKKKIWDVQPDAGPVRAEDAYLSPFHQACERYAKT FFDEWVILSAKHGFLRPDDLVSGNYDVTFGTGHPEIMTADELRRQFHEKGFSDIEELV MLGGKKYRSVLNAVIGEHQHISWPLSSYKGIGYMLQALNRAVEEKHEL*" /label="yfjM CDS" gene 779761..780213 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /label="yfjM gene" CDS 780243..780932 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388686.1" /db_xref="EnsemblGenomes-Gn:BSU08050" /db_xref="EnsemblGenomes-Tr:CAB12634" /db_xref="InterPro:IPR020523" /db_xref="SubtiList:BG11034" /db_xref="UniProtKB/Swiss-Prot:P40773" /translation="MKKLVFGLLAIVLFGCGLYIYHVWFGDPFSKNAAEQKLVSYVKQ TYPKKEIKITNGVYNAKTSEYVFEATSQSHRYPMCTKGFLHPKVTCDGIEEAYTESVA KHVNEEATKAIEADLKKAVPRFIKADAALSIENGQFTLDTKWNKKLAEKAPMSMTIQL DASGLSKTDAAKMAETVRKTLNEKGYTYSNGTIDCMQKDGDGGIGYVKYSIDFLSKAA IQSNDAEELGS*" /label="yfjL CDS" gene 780243..780932 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /label="yfjL gene" downshifts 780937 /Source="Nicolas_upshifts" /id="D404" /incds=0 /nref=31 /ntot=205 /MaxReadThrough="0.02745" /MaxDrop="3.61164" /score="23.9796437" /energy="-9" /TU="NA" /idTUdmin="U617" /TUdmin=1 /isTUend="TRUE" /label="downshifts" misc_feature 781109..781127 /Source="Nicolas_upshift_promotors" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 781116 /Source="Nicolas_upshifts" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 781164..782165 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109, 22714279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109, 22714279; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent alpha subunit)" /protein_id="NP_388687.1" /db_xref="EnsemblGenomes-Gn:BSU08060" /db_xref="EnsemblGenomes-Tr:CAB12635" /db_xref="GOA:O31404" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12558" /db_xref="UniProtKB/Swiss-Prot:O31404" /translation="MKLLKREGLSLTEEKALWMYQKMLEIRGFEDKVHELFAQGVLPG FVHLYAGEEAVAVGVCAHLHDGDSITSTHRGHGHCIAKGCDLDGMMAEIFGKATGLCK GKGGSMHIADLDKGMLGANGIVGGGFTLACGSALTAKYKQTKNVSVCFFGDGANNQGT FHEGLNLAAVWNLPVVFVAENNGYGEATPFEYASACDSIADRAAAYNMPGVTVDGKDI LAVYQAAEEAIERARNGGGPSLIECMTYRNYGHFEGDAQTYKTKDERVEHLEEKDAIQ GFKNYLLKETDANKLSDIEQRVSESIEKAVSFSEDSPYPKDSELLTDVYVSYEKGGM* " /label="acoA CDS" gene 781164..782165 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /label="acoA gene" CDS 782169..783197 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 10368162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 10368162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent beta subunit)" /protein_id="NP_388688.1" /db_xref="EnsemblGenomes-Gn:BSU08070" /db_xref="EnsemblGenomes-Tr:CAB12636" /db_xref="GOA:O34591" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG12559" /db_xref="UniProtKB/Swiss-Prot:O34591" /translation="MARVISMSDAINEAMKLAMRKDENVLLIGEDVAGGAAVDHLQDD EAWGGVLGVTKGLVQEFGRTRVLDTPISEAGYMGAAMAAASTGLRPIAELMFNDFIGT CFDQVINQGAKFRYMFGGKAQVPITVRTTYGAGFRAAAQHSQSLYGLFTSIPGLKTVV PSNPYDAKGLLLAAIEDNDPVFFFEDKTSYNMKGEVPEDYYTIPLGKADIKREGNDVT LFAVGKQVNTALEAAAQLSERGIEAEVLDPRSLSPLDEDAIFTSLEKTNRLIIIDEAN PRCSIATDIAALVADKGFDLLDAPIKRITAPHTPVPFSPVLEDQYLPTPDKIVSVTLE LLGEPALN*" /label="acoB CDS" gene 782169..783197 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /label="acoB gene" CDS 783211..784407 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /EC_number="2.3.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase)" /protein_id="NP_388689.1" /db_xref="EnsemblGenomes-Gn:BSU08080" /db_xref="EnsemblGenomes-Tr:CAB12637" /db_xref="GOA:O31550" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG12560" /db_xref="UniProtKB/Swiss-Prot:O31550" /translation="MAVKVVMPKLGMAMKQGEVSIWNKKVGDPVEKGESIASIQSEKI EMEIEAPEKGTLIDIKVKEGEEVPPGTAICYIGDANESVQEEAGAPVAEDNMPQAVQP VKQENKPAASKKDRMKISPVARKIAEKAGLDLKQLKGTGPGGRIVKDDVTKALAEQKK DQAKPVSEQKAQEIPVTGMRKVIAARMQESLANSAQLTITMKADITKLATLQKQLSPT AEERYGTKLTITHFVSRAAVLALQAHPVLNSFYQNERIITHPHVHLGMAVALENGLVV PVIRHAEKLSLIELAQSISENAKKAREGRAGSEELQGSTFSITNLGAFGVEHFTPILN PPETGILGIGASYDTPVYQGEEIVRSTILPLSLTFDHRACDGAPAAAFLKAMKTYLEE PAALIL*" /label="acoC CDS" gene 783211..784407 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /label="acoC gene" downshifts complement(783212) /Source="Nicolas_upshifts" /id="D405" /incds=0 /nref=8 /ntot=46 /MaxReadThrough="0.481579999999999" /MaxDrop="4.16582" /score="-0.0231058321" /energy="-9.9" /TU="NA" /idTUdmin="U623" /TUdmin=4796 /isTUend="FALSE" /label="downshifts" CDS 784428..785804 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /EC_number="1.8.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase)" /protein_id="NP_388690.1" /db_xref="EnsemblGenomes-Gn:BSU08090" /db_xref="EnsemblGenomes-Tr:CAB12638" /db_xref="GOA:O34324" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12561" /db_xref="UniProtKB/Swiss-Prot:O34324" /translation="MTLAIIGGGPAGYAAAVSAAQQGRNVLLIDKGKLGGTCLNEGCI PTKSLLESANVLDKIKHADSFGIELPAGAISVDWSKMQSRKQQVVSQLVQGVQYLMKK NQIQVVKGTASFLSERKLLIEGENGKEIREADQVLIASGSEPIELPFAPFDGEWILDS KDALSLSEIPSSLVIVGGGVIGCEYAGLFARLGSQVTIIETADRLIPAEDEDIARLFQ EKLEEDGVEVHTSSRLGRVDQTAKTAIWKSGQREFKTKADYVLVAIGRKPRLDGLQLE QAGVDFSPKGIPVNGHMQTNVPHIYACGDAIGGIQLAHAAFHEGIIAASHASGRDVKI NEKHVPRCIYTSPEIACIGMTERQARSIYGDVKIGEFSFSANGKALIKQQAEGKVKIM AEPEFGEIVGVSMIGPDVTELIGQAAAIMNGEMTADMAEHFIAAHPTLSETLHEALLS TIGLAVHA*" /label="acoL CDS" gene 784428..785804 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /label="acoL gene" downshifts 785798 /Source="Nicolas_upshifts" /id="D406" /incds=0 /nref=27 /ntot=56 /MaxReadThrough="5.75671" /MaxDrop="5.6153" /score="27.0133719" /energy="-14.7" /TU="U619" /idTUdmin="U619" /TUdmin="-2156" /isTUend="FALSE" /label="downshifts" promotor_-35 785851..785858 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 785871..785890 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 785879 /Source="Nicolas_upshifts" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 785920..787737 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /experiment="publication(s) with functional evidences, PMID:11274109, 16944132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 16944132; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AcoR-acetoin)" /protein_id="NP_388691.1" /db_xref="EnsemblGenomes-Gn:BSU08100" /db_xref="EnsemblGenomes-Tr:CAB12639" /db_xref="GOA:O31551" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG11790" /db_xref="UniProtKB/Swiss-Prot:O31551" /translation="MNSVPNDLQTWKRFVKDGVLDEARLRKRIAESWHRCKKAEVNPY LEKGPKVLQQTELDQQSKKHSFFLTTAKPYLEKLLPAIKEMEMMALLIDSDGVVLALD GHPRALYEAKRINFVEGACWTETAVGTNAIGTALHISEPVAIQGSEHYSIASHLWNCS AAPIHHEDGSLAGVIDISCPAAGAHPHMLGIATAIAYAAERELAAKSREKELELISRF GERAASSVPMVLCNTKQHIISASMPIRTSMPDWQGRHLYELKERGYSIENAVTIGDGG TCFYLSEQKKKKAFRFNGVIGQSGRSQAMLMHLERAAATDASVCLSGETGTGKEVAAR ALHENSERRHGPFVAVNCGAIPSDLIESELFGYAEGAFTGAKRNGYKGAFQKANQGTL FLDEIGEISHSMQVALLRVLQERKITPIGGTKEIPVDIRVIAATHCDLRELAENGKIR EDLFYRLHVYPIELPPLRDRTEDIPDLFEYYKQKNHWPGDLPSDFCNVLKQWKWPGNI RELFNVFERLSIRFPDGRLRDESLPALLEAAGLPASSAEKKPAAAGVLTFREQIQKDM MIKALESAKGNVSQAAKISGIPRSTFYKRLKKFNLSAES*" /label="acoR CDS" gene 785920..787737 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /label="acoR gene" promotor_-35 787738..787744 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 787756 /Source="Nicolas_upshifts" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 787759..787770 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 787791..787970 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_388692.1" /db_xref="EnsemblGenomes-Gn:BSU08110" /db_xref="EnsemblGenomes-Tr:CAB12640" /db_xref="GOA:O31552" /db_xref="InterPro:IPR012610" /db_xref="SubtiList:BG12917" /db_xref="UniProtKB/Swiss-Prot:O31552" /translation="MNIQRAKEIVESPDMKKVTYNGVPIYIQHVNEETGTARIYPLDE PQEEHEVQLNSLKED*" /label="sspH CDS" gene 787791..787970 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /label="sspH gene" downshifts 787954 /Source="Nicolas_upshifts" /id="D407" /incds=0 /nref=96 /ntot=181 /MaxReadThrough="1.9176" /MaxDrop="6.06509" /score="5.08326573" /energy="-12" /TU="NA" /idTUdmin="U619" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(788006..788335) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388693.1" /db_xref="EnsemblGenomes-Gn:BSU08120" /db_xref="EnsemblGenomes-Tr:CAB12641" /db_xref="GOA:O31553" /db_xref="InterPro:IPR003844" /db_xref="SubtiList:BG12908" /db_xref="UniProtKB/Swiss-Prot:O31553" /translation="MMLITILLFLAAGLAEIGGGYLVWLWLREAKPAGYGIAGALILI VYGILPTFQSFPSFGRVYAAYGGVFIVLAVLWGWLVDRKTPDLYDWIGAFICLIGVCV ILFAPRG*" /label="yfjF CDS" gene complement(788006..788335) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /label="yfjF gene" downshifts complement(788020) /Source="Nicolas_upshifts" /id="D408" /incds=0 /nref=96 /ntot=245 /MaxReadThrough="2.05328" /MaxDrop="6.2642" /score="34.1179702" /energy="-15.8" /TU="NA" /idTUdmin="U623" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(788385..788843) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388694.1" /db_xref="EnsemblGenomes-Gn:BSU08130" /db_xref="EnsemblGenomes-Tr:CAB12642" /db_xref="GOA:O31554" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12907" /db_xref="UniProtKB/Swiss-Prot:O31554" /translation="MSEALTFESKYALLYLGGGLLAMIYGLITFFMAFPAFTSRGNVI FTIKTGPSGEIFLRKRSVLFSEVKRLYMGRHQYSLKGIFFEDIIIEKTDGKIVRIPTW NIITNPLFFEAVERYILPHLNEEAQNNWISQFTEVQRKAYLKEFENHPKL*" /label="yfjE CDS" gene complement(788385..788843) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /label="yfjE gene" S_feature complement(788844..788936) /Source="Nicolas_S_feature" /locus_tag="new_886682_886774_c" /HighExp="BI, BC, S2, Sw, HiOs, HiTm, S5, ferm, S4, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S282" CDS complement(788937..789494) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388695.1" /db_xref="EnsemblGenomes-Gn:BSU08140" /db_xref="EnsemblGenomes-Tr:CAB12643" /db_xref="GOA:O31555" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12906" /db_xref="UniProtKB/Swiss-Prot:O31555" /translation="MKNQEIIEVKSKMFLRIWAFVGSAGMGLACLWLFYMGITFQTKY YLLAIPAGFLFTLFCLYLFIIFFPAFTPRGNTIFRIKTGKNGEVFTDKVSVTFTDIKK IEMSRHKFSLKGIFQEDILIQTVDQKTIRIPTWNIIPNPLFFEAVERYILPHLNEEAK SNWIGQFTDIQRSAYLKEFENHPKL*" /label="yfjD CDS" gene complement(788937..789494) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /label="yfjD gene" promotor_-35 789360..789365 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 789373 /Source="Nicolas_upshifts" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 789380..789398 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 789384..789971 /Source="Nicolas_S_feature" /locus_tag="new_887222_887809" /HighExp="S4, S5, S6, S3, S8, S7, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="yfjC" /AntisenseCor="9.3643586039105595E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S283" CDS complement(789526..790293) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388696.1" /db_xref="EnsemblGenomes-Gn:BSU08150" /db_xref="EnsemblGenomes-Tr:CAB12644" /db_xref="SubtiList:BG12905" /db_xref="UniProtKB/Swiss-Prot:O31556" /translation="MKQFTISIEELLFCFYSEGFFEQGMALKQAYFPEIEDEQLGALF EAACRSLLAKDAAEYRNHQYRLKDEYCPFIHVLNDADYTVKLSKFNGQGAEQNVSCHV SKFGTYSHELLFDEQVHRITKMESSEGLLAKTDEFLHIIDTEDKRESIVTLTSNEFEK LLEGASDNPSYLKEFLEKHDHQEDVTRFANDLALRKGKMDTLMRLAYGKDNTPEVADM AFVLPGAHHTWLVTGITQNEFSILPAHKDVVNQIISK*" /label="yfjC CDS" gene complement(789526..790293) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /label="yfjC gene" CDS complement(790305..791528) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388697.1" /db_xref="EnsemblGenomes-Gn:BSU08160" /db_xref="EnsemblGenomes-Tr:CAB12645" /db_xref="SubtiList:BG12904" /db_xref="UniProtKB/Swiss-Prot:O31557" /translation="MSGNIAVDPDKLEQLANDVVTELTDMENKYKDLHVELGQMILQC DPRYSSCFSGVGDAWSSGKALVTKLSDNEIFIRKTGDKFVEQDDILRKLYNAYDKYGT MTSLTALMLTQGKYYGLGLTKFVKQPSGLHTAQHSKLLLDISRAVDSSRYQKAARVLL NPKYLLKKTNRPFSDLVHKKFTKYFPQDTVDFSNSVRSYTKGFLNEAGVRSTLKDVGK TGLRFAKGNAITATLITGATETFGAGVKIAENYAKYQDKPEVLKRENAKAVGNAVNNT IFVAGGATAGAVIGGAIGSFAGPVGTVLLGAAGSYIGGVVGEQIAKYTAGFAEKAALK LKEPIHAVVDTAKKGLESAGKVVKSVNDGIDAANKSIHKGIDSAKKGMEKAKKTADSL IHGATHFLKGKFSFG*" /label="yfjB CDS" gene complement(790305..791528) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /label="yfjB gene" CDS complement(791534..791848) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388698.1" /db_xref="EnsemblGenomes-Gn:BSU08170" /db_xref="EnsemblGenomes-Tr:CAB12646" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12903" /db_xref="UniProtKB/Swiss-Prot:O31558" /translation="MDSYKVIELANKYSAAAEEVRSSKMLLESRLSALGDAWQGKARD SFDQDFEETKAAYDQFEQELLETSQELKAAAVKIEERKAEIARMEELERKAREERHKL GR*" /label="yfjA CDS" gene complement(791534..791848) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /label="yfjA gene" promotor_-10 complement(791896..791915) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(791909) /Source="Nicolas_upshifts" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(791930..791933) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 792140..792159 /Source="Nicolas_upshift_promotors" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 792143 /Source="Nicolas_upshifts" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="upshifts" CDS 792184..793533 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /EC_number="3.2.1.122" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-alpha-glucosidase" /protein_id="NP_388699.1" /db_xref="EnsemblGenomes-Gn:BSU08180" /db_xref="EnsemblGenomes-Tr:CAB12647" /db_xref="GOA:P54716" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:1U8X" /db_xref="SubtiList:BG11839" /db_xref="UniProtKB/Swiss-Prot:P54716" /translation="MKKKSFSIVIAGGGSTFTPGIVLMLLDHLEEFPIRKLKLYDNDK ERQDRIAGACDVFIREKAPDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIP LKYGVVGQETCGPGGIAYGMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRR LRPNSKILNICDMPVGIEDRMAQILGLSSRKEMKVRYYGLNHFGWWTSIQDQEGNDLM PKLKEHVSQYGYIPKTEAEAVEASWNDTFAKARDVQAADPDTLPNTYLQYYLFPDDMV KKSNPNHTRANEVMEGREAFIFSQCDMITREQSSENSEIKIDDHASYIVDLARAIAYN TGERMLLIVENNGAIANFDPTAMVEVPCIVGSNGPEPITVGTIPQFQKGLMEQQVSVE KLTVEAWAEKSFQKLWQALILSKTVPNARVARLILEDLVEANKDFWPELDQSPTRIS* " /label="malA CDS" gene 792184..793533 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /label="malA gene" misc_feature 793562..793581 /Source="Nicolas_upshift_promotors" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 793564 /Source="Nicolas_upshifts" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="upshifts" CDS 793598..794362 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489864, 16707683, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489864, 16707683, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the Mal operon" /protein_id="NP_388700.1" /db_xref="EnsemblGenomes-Gn:BSU08190" /db_xref="EnsemblGenomes-Tr:CAB12648" /db_xref="GOA:P54717" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11847" /db_xref="UniProtKB/Swiss-Prot:P54717" /translation="MQLEELINQHYSKLNDNDFHILKYILNHKHTCYHLGIDALAKAC SVSRSSILRLAQKLGFSGYSEFRVFLKWEDQPEEGESMSFEKLLDDIEANLKFLRTKD MTDMCQLIDAADRIFVYGSGNAQKICARDLQRMFIPRHRYLILIEDTNEFNLMRDDFK VNDLFIIISLSGETPELIPQARMLSAKGIPFISITNLKNNVLAQLTPHNLYATSKPVT LSDRTEIVAFAPFFLVGEALFRAYVDYKEAEKNDNE*" /label="malR CDS" gene 793598..794362 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /label="malR gene" promotor_-10 complement(793742..793756) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(793772..793778) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(793772) /Source="Nicolas_upshifts" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 794377..795960 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) maltose-specificenzyme IICB component" /protein_id="NP_388701.1" /db_xref="EnsemblGenomes-Gn:BSU08200" /db_xref="EnsemblGenomes-Tr:CAB12649" /db_xref="GOA:P54715" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010975" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11848" /db_xref="UniProtKB/Swiss-Prot:P54715" /translation="MMQKIQRFGSAMFVPVLLFAFAGIIVGISTLFKNKTLMGPLADP DGFWYQCWYIIEQGGWTVFNQMPLLFAIGIPVALAKKAQARACLEALTVYLTFNYFVS AILTVWGGAFGVDMNQEVGGTSGLTMIAGIKTLDTNIIGAIFISSIVVFLHNRYFDKK LPDFLGIFQGSTYIVMISFFIMIPIALAVSYIWPMVQSGIGSLQSFLVASGAVGVWIY TFLERILIPTGLHHFIYTPFIYGPAVAEGGIVTYWAQHLGEYSQSAKPLKELFPQGGF ALHGNSKIFGIPGIALAFYVTAKKEKKKLVAGLLIPVTLTAIVAGITEPIEFTFLFIS PFLFAVHAVLAATMSTVMYMAGVVGNMGGGLIEAVTLNWIPLFGSHGMTYVYQILIGL SFTAIYFFVFRFLILKFNIATPGREKDEQQETKLYSKKEYRERKNKDETASAAETADD TAFLYIEALGGKDNITEVTNCATRLRVSVKDETKVEPDSVFRALGAHGVVRNGKAFQV IIGLSVPQMRERVEKILNQ*" /label="malP CDS" gene 794377..795960 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /label="malP gene" downshifts 795940 /Source="Nicolas_upshifts" /id="D409" /incds=0 /nref=23 /ntot=46 /MaxReadThrough="3.26652" /MaxDrop="4.69656" /score="8.65399085" /energy="-10.9" /TU="U624" /idTUdmin="U625" /TUdmin=836 /isTUend="FALSE" /label="downshifts" promotor_-35 795989..795996 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 796011..796030 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 796019 /Source="Nicolas_upshifts" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="upshifts" CDS 796066..797787 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative xenobiotic ABC transporter subunit (ATP-binding protein)" /protein_id="NP_388702.1" /db_xref="EnsemblGenomes-Gn:BSU08210" /db_xref="EnsemblGenomes-Tr:CAB12650" /db_xref="GOA:P54718" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11849" /db_xref="UniProtKB/Swiss-Prot:P54718" /translation="MQKALSFLKPYSLLAGIALILMLTELAVELMQPLLIAKIIDDGI LKQDLRHVWIWGTVMIGLTVLSFAAGMLNSFYAAHVSQSFSYDTRKGLFQKIQSFSYS TFGQFSSSSYITRLTNDVTQVQNMIFMSLRFMLRAPLMIAGGIVLSLAVNVKLGFFLL VTIPILILFLLWVLRKGGALFRSVQKRLDQVNTIMQENLIAIKLIKALLRGSHEVKRF IKANTRLMEKTVSAFQLVEFTMPVLMLLMNLCILLILWAGSYSITSGSTQVGDVVAII NYATRITGALSMFPFLIMIFTRAKASGDRIGEVLETEGDEREEGTISDRLSGRIEFQH VSFRYPEMDREALRNVSFSAKPRETIAILGATGSGKSTLFQLIPRLYQPDSGRIYIDE KPVQDIPAEGLRRQIGYVPQEVLLFSGTIKENIAWGKENASLDEIMDAAKLAQIHETI LKLPNGYDTVLGQRGVNLSGGQKQRISIARALIRKPAILLLDDSTSALDLQTEAKLLE AISTYHCTTLIITQKITTAMKADQILLLEDGELIEKGTHSELLSESQLYKRIYESQFG REGSESC*" /label="yfiB CDS" gene 796066..797787 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /label="yfiB gene" CDS 797781..799595 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388703.1" /db_xref="EnsemblGenomes-Gn:BSU08220" /db_xref="EnsemblGenomes-Tr:CAB12651" /db_xref="GOA:P54719" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11850" /db_xref="UniProtKB/Swiss-Prot:P54719" /translation="MLKDIRKPFQYPKLPIDKKEGAKKRAKAKDTKGTLRRIWSYLAE RKGLLILVMLMVVISAIFGLLGPFVIGKAIDHFIVGKTVSGLIPVLLLLLAIYIIQSL SLWFQNYWMITISQGTVFRMRSELFTHLHELPIPFFDKQRHGELMSRVTNDIENVSST LNTSVIQILSSVITFVGTIAVMLYMSPLLTLITLTIIPVMAASLKWITNRTGKLFKEQ QKNLGDLNGYIEESVSGAKVIKAYSREKQITAEFLEKNAALKTSGFWAQTISGFIPKV MNSLNNLSFTMIAAIGGLFALKGWISIGSIVVFAEYSRQFTRPLNDLANQFNTMLSAI AGAERVFDVLDEKEEREDEKNAVHQPIQTGSIEFRDVSFGYDKGQQTLKHLQFTVPAG QSIAFVGPTGAGKTTVTNLLARFYEPNDGKILIDGTDIKTLTRASLRKNMGFVLQDSF LFQGTIRENIRYGRLDASDQEVEAAAKTANAHSFIERLPKGYDTVLTQNGSGISQGQK QLISIARAVLADPVLLILDEATSNIDTVTEVNIQEALARLMEGRTSVIIAHRLNTIQR ADQIVVLKNGEMIEKGSHDELIRQKGFYSDLYESQFEK*" /label="yfiC CDS" gene 797781..799595 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /label="yfiC gene" downshifts 799570 /Source="Nicolas_upshifts" /id="D410" /incds=0 /nref=103 /ntot=190 /MaxReadThrough="2.4559" /MaxDrop="5.61906" /score="24.4395842" /energy="-11" /TU="NA" /idTUdmin="U627" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 799677..799684 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 799698..799717 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 799702 /Source="Nicolas_upshifts" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="upshifts" CDS 799750..800154 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16872404, 16850406, 17407181, 20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16872404, 16850406, 17407181, 20639328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase membrane subunit" /protein_id="NP_388704.1" /db_xref="EnsemblGenomes-Gn:BSU08230" /db_xref="EnsemblGenomes-Tr:CAB12652" /db_xref="GOA:P54720" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG11851" /db_xref="UniProtKB/Swiss-Prot:P54720" /translation="MNKSFEIGTLLLRVITGIIFFVHGLSKFQGMEGTIQFFGSIGLP SFMAYVIAAIELIGGVLVFFGLATRIVGVLFALTLIGAIITVKLKAPFMGNAEFDYLL LLTSIHLALTGSRFLALDPFVFKGKKNGNVSA*" /label="catD CDS" gene 799750..800154 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /label="catD gene" CDS 800172..801029 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17407181, 16872404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 16872404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase subunit" /protein_id="NP_388705.2" /db_xref="EnsemblGenomes-Gn:BSU08240" /db_xref="EnsemblGenomes-Tr:CAB12653" /db_xref="GOA:P54721" /db_xref="InterPro:IPR000486" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11852" /db_xref="UniProtKB/Swiss-Prot:P54721" /translation="MTSIHEDTHIGYAKLTIRSLERSLQFYCNVIGFQVLKKTDRQAE LTADGKRVLLILEENPSAVVLPERSVTGLYHFAILLPDRKELGIALARLIEHGIAIGH GDHAVSEALYLSDPDGNGIEMYADRPRSTWQRDREGNYVMTTTAVDIEGLLEEAGDER KTSLPNDTIIGHIHLHVSDLKEAKAFYTDVLGFDIVGNYAGMSALFVSAGGYHHHIGL NIWAGRNAPPKPTNASGLDYYTVVLPHQEELDLVANRVKHAGYSIEETENSFRVKDPV SGAYITFVI*" /label="catE CDS" gene 800172..801029 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /label="catE gene" downshifts 801016 /Source="Nicolas_upshifts" /id="D411" /incds=0 /nref=4 /ntot=21 /MaxReadThrough="0.66359" /MaxDrop="3.74886" /score="50.8573531" /energy="-19.7" /TU="NA" /idTUdmin="U628" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS 801123..802067 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family; cupin family)" /protein_id="NP_388706.1" /db_xref="EnsemblGenomes-Gn:BSU08250" /db_xref="EnsemblGenomes-Tr:CAB12654" /db_xref="GOA:P54722" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11853" /db_xref="UniProtKB/Swiss-Prot:P54722" /translation="MELNHLVTGKIALNQYVHRLEQKDVSFYVHYWGAMTNHYNTLLH KHSFYEICYVVRGEGYYLEGDRTYPLREQTIFLSKPEHLHQIKSETGLFLFYVAFELS EDQSSAEWIKVMEEVKQSPFITMQLKDGEPPGLLWKTLMLQAAQPVNAFDKEILSHLS HALILSLIQTFLPYAQRPKQKQPIHTSSALLTEVKLHIKDNLSQPLKLTDVASHFHIS GRHLSRLFAAELGVSYSEFVQNEKINKAAELLKSTNLSIKEIAEEIGFSVHYFTRVFS AKIGSSPGLFRSLYKDSKMTAFQINKPFQKIEQAKPHE*" /label="yfiF CDS" gene 801123..802067 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /label="yfiF gene" downshifts complement(801934) /Source="Nicolas_upshifts" /id="D412" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="-0.20031" /MaxDrop="3.51831" /score="-4.19869956" /energy="-9.5" /TU="NA" /idTUdmin="U632" /TUdmin=9372 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(801982..802082) /Source="Nicolas_upshift_promotors" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(802022) /Source="Nicolas_upshifts" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 802242..803690 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar/proton transporter" /protein_id="NP_388707.1" /db_xref="EnsemblGenomes-Gn:BSU08260" /db_xref="EnsemblGenomes-Tr:CAB12655" /db_xref="GOA:P54723" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11854" /db_xref="UniProtKB/Swiss-Prot:P54723" /translation="MSTKKKEAVIGKESLAHKGLLRTITLVSTFGGLLFGYDTGVING ALPFMATAGQLNLTPVTEGLVASSLLLGAAFGAMFGGRLSDRHGRRKTILYLALLFIA ATLGCTFSPNASVMIAFRFLLGLAVGCASVTVPTFLAEISPAERRGRIVTQNELMIVI GQLLAYTFNAIIGSTMGESANVWRYMLVIATLPAVVLWFGMLIVPESPRWLAAKGRMG DALRVLRQIREDSQAQQEIKEIKHAIEGTAKKAGFHDFQEPWIRRILFIGIGIAIVQQ ITGVNSIMYYGTEILREAGFQTEAALIGNIANGVISVIAVIFGIWLLGKVRRRPMLII GQIGTMTALLLIGILSIVLEGTPALPYVVLSLTILFLAFQQTAISTVTWLMLSEIFPM HVRGLGMGISTFCLWTANFLIGFTFPILLNHIGMSATFFIFVAMNILAILFVKKYVPE TKGRSLEQLEHSFRQYGRRADQEIQNQTTHLS*" /label="yfiG CDS" gene 802242..803690 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /label="yfiG gene" CDS 803717..804658 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_388708.1" /db_xref="EnsemblGenomes-Gn:BSU08270" /db_xref="EnsemblGenomes-Tr:CAB12656" /db_xref="InterPro:IPR011418" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11855" /db_xref="UniProtKB/Swiss-Prot:P54724" /translation="MKLSYVTDSLGHLPFEDMLNFAAKLGIDTLEMTTGGWSPAPHLN LDELLQSSEKRKEFSQALEKRNMTLCALNCSGNPLDPGELGKSHRDITDKTMELAGLL GVKKVIMMSGLPAGGPDDKVPNWITYTVSWPPVLKDILNYQWEDVAIPYWKKLVKKAE ACGVGKIALENFSSQLVYNPETLFRLRNAVGPMVGLNLDPSHLLWMGADPIIAARELG SAIHHVHGKDVRIERYLSAVNGLLETKEVTDPANRAWNYVAVGCGQDLQWWKEFFSVV KMMGYEGEVSLEMEDLTMSPEAGIRTSVEALKQTISQ*" /label="yfiH CDS" gene 803717..804658 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /label="yfiH gene" CDS 804668..805849 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26438878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388709.1" /db_xref="EnsemblGenomes-Gn:BSU08280" /db_xref="EnsemblGenomes-Tr:CAB12657" /db_xref="GOA:P94437" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12214" /db_xref="UniProtKB/Swiss-Prot:P94437" /translation="MMLNGERIISKPLRWAMVGGGRLSQVGYKHRIGALRDNTAFQLT AGAFDIDAERGKDFGVNLGVDAERCYPNYQTMFAEEAKRQDGIEVVSIATPNGTHYEI CKAALEAGVHVICEKPLFFTSAEGQEIKALAEKKGKIVGVTYGFSGNQMLLQMRAMIE QGMIGDIRVVDLQYTHGFCATDEGEKISAAQKWRVDPAIAGPSFVLGDLSTHTYYMSQ LIMPKMKIKELLCDRQSFVGSRAPLEDNAHVLMHYENGAVGTMWTSSINAGCMDGHRI RIVGSKASIEWWDSKPNELTYEVQGEPGQTLVRGMPYLDDVCNADERLGALHSEGLSE AWANIYLKFAIAIDAKNREDEEILNNLVYPDIDAGIEGIRWIENCVRSANQGSVWVEF K*" /label="yfiI CDS" gene 804668..805849 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /label="yfiI gene" downshifts 805839 /Source="Nicolas_upshifts" /id="D413" /incds=0 /nref=40 /ntot=113 /MaxReadThrough="0.88387" /MaxDrop="5.80704" /score="14.819468" /energy="-13" /TU="NA" /idTUdmin="U630" /TUdmin="-2003" /isTUend="FALSE" /label="downshifts" promotor_-35 805909..805915 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 805930..805949 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 805948 /Source="Nicolas_upshifts" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="upshifts" CDS 805973..807175 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /function="16.12: Sense" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LinK] (linearmycin resistance, biofilm formation)" /protein_id="NP_388710.1" /db_xref="EnsemblGenomes-Gn:BSU08290" /db_xref="EnsemblGenomes-Tr:CAB12658" /db_xref="GOA:P94438" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12215" /db_xref="UniProtKB/Swiss-Prot:P94438" /translation="MKALFFTRMFTLMVSCLMYLSIVKEDNWFGYVFIAAGAAMYAAN HVLLTKETNAIWFCLIDIAIGFSFGFIFPGTGLFIIMLCPVAVAFFLRGFPKRTAWSV LCLSSILFLTVLIRTYAMFGNEFVIDHLTSMTFVVFCGVVGKLIRKLLDAQDTAKQQF QELTESHLALSAAHQELHLYAKQVEELTAIYERNRMAREIHDTVGHKMTALLVQLQLL REWQKRDSQKADETVGVCETLAREALDDVRLSVRTLQTENDPSLIESLKQLTEDFCKN AGVTTEFAVSGDPAIIPLSLHPTLIRTVQEALTNAKRHGGAAACSIQLACTTDSISLV IKDDGKGNPEAALGFGLLNMKKRAAEHGGMIRFESERDQGFTVNAEFSLANKKWSFGP VQQKESLS*" /label="linJ CDS" gene 805973..807175 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /label="linJ gene" CDS 807172..807834 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LinJ] (linearmycin resistance, biofilm formation)" /protein_id="NP_388711.1" /db_xref="EnsemblGenomes-Gn:BSU08300" /db_xref="EnsemblGenomes-Tr:CAB12659" /db_xref="GOA:P94439" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12216" /db_xref="UniProtKB/Swiss-Prot:P94439" /translation="MIKIIITDDQDIVREGLASLLQLREELDVIATARNGQEAFEKAK ELEPDIVLMDIRMPVSNGVEGTKLITSSLPSVKVLMLTTFKDSALIAEALEEGASGYL LKDMSADTIVKAVMTVHSGGMVLPPELTAQMLNEWKREKQLKGINEIEKPNELLDLTE REIEVLAELGYGLNNKEIAEKLYITEGTVKNHVSNIISKLAVRDRTQAAIYSVRYGVS VF*" /label="linK CDS" gene 807172..807834 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /label="linK gene" downshifts 807842 /Source="Nicolas_upshifts" /id="D414" /incds=0 /nref=114 /ntot=229 /MaxReadThrough="-0.0105699999999995" /MaxDrop="4.23231" /score="20.4785449" /energy="-7.6" /TU="NA" /idTUdmin="U630" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 807978..808913 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) biofilm formation" /protein_id="NP_388712.2" /db_xref="EnsemblGenomes-Gn:BSU08310" /db_xref="EnsemblGenomes-Tr:CAB12660" /db_xref="GOA:P94440" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12217" /db_xref="UniProtKB/Swiss-Prot:P94440" /translation="MLQAENIKKAYGKKTIVKGISFSLKKGESFGLLGPNGAGKSTTI SMISGLVPHDSGNITVGGYVIGKETAKAKQKIGIVPQEIALYPTLTAHENLMFWGKMY GLTHGEAKKRAAEVLEYVGLTERAKDKIETFSGGMKRRINIGAALMHKPELLIMDEPT VGIDPQSRNHILETVKQLNETGMTVIYTSHYMEEVEFLCDRIGIIDQGEMIAIGTKTD LCSRLGGDTIIQLTVSGINEAFLVAIRSLAHVNDVTVHELELKIDISAAHHEKVVTSL LAEATAHHINLLSLQVQEPNLERLFLNLTGRTLRD*" /label="bifL CDS" gene 807978..808913 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /label="bifL gene" CDS 808926..810116 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388713.1" /db_xref="EnsemblGenomes-Gn:BSU08320" /db_xref="EnsemblGenomes-Tr:CAB12661" /db_xref="GOA:P94441" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12218" /db_xref="UniProtKB/Swiss-Prot:P94441" /translation="MKKSIWIAWKDVKIRITDRKGFMMLILMPLILTCILGAALGSVV DGGSRIDDIKVGYIQSDQSDTANMFTKDVLKKMKSIKVTKVGSKDKMKKLIDEKKIDV GIVIPNHWEAGKTSAVVNAAPDQTLKSSIIETAASSFIEQYKAVKEAASGSMDYISKT EAVKQGKLDPAQFAEKLAKTLEKETGDKLTIAEKSVGSKAVTSFQYYSAAMLCMFMLF HITVGAKSFLQEKDTETLARMLMTPAQKSVILFGKWLGTYLFAIIQFFIFLIVTINVF GVDWGGNLLLVSVLGLSYAAAVSGISMLLASCISDMKTADAIGGFGIQLLAVLGGSML PLYQFPDVLQSVSKAVPNRWALDGFLSLMEGGGWADLQKPVLLFAAIGFCSLVIGIRR LHTR*" /label="bifM CDS" gene 808926..810116 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /label="bifM gene" CDS 810130..811287 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388714.1" /db_xref="EnsemblGenomes-Gn:BSU08330" /db_xref="EnsemblGenomes-Tr:CAB12662" /db_xref="GOA:P94442" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12219" /db_xref="UniProtKB/Swiss-Prot:P94442" /translation="MKKILAICGIELSLIFKKPQNYLIMFAAPLLLTFVFGSMLSGND DKVRLAIVDQDDTILSQHYIRQLKAHDDMYVFENMSESKASEKLKQKKIAGIIVISRS FQTQLEKGKHPELIFRHGPELSEAPMVKQYAESALATLNIQVTAAKTASQTAGENWKA AYKTVFAKKHEDIVPAVTRQTLSDKKEGAEASDTASRAAGFSILFVMLTMMGAAGTIL EARKNGVWSRLLTASVSRAEIGAGYVLSFFVIGWIQFGILLLSTHWLFGINWGNPAAV IVLVSLFLLTVVGIGLMIAANVRTPEQQLAFGNLFVIATCMVSGMYWPIDIEPKFMQS IAEFLPQKWAMSGLTEIIANGARVTDILGICGILLAFAAITFAAGLKALRA*" /label="bifN CDS" gene 810130..811287 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /label="bifN gene" promotor_-35 810241..810246 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 810261..810279 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 810262 /Source="Nicolas_upshifts" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(811285..811359) /Source="Nicolas_S_feature" /locus_tag="new_909123_909197_c" /HighExp="LoTm, Sw, C90, HiOs, BC, MG 45, UNK1, Fru, S1, BI" /AntisenseName="yfiN" /AntisenseCor="-6.3486715356968801E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S284" downshifts complement(811328) /Source="Nicolas_upshifts" /id="D415" /incds=0 /nref=90 /ntot=257 /MaxReadThrough="1.41433" /MaxDrop="6.01369" /score="13.7314837" /energy="-11.5" /TU="U632" /idTUdmin="U632" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(811360..811908) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of phenolic acid decarboxylase" /protein_id="NP_388715.1" /db_xref="EnsemblGenomes-Gn:BSU08340" /db_xref="EnsemblGenomes-Tr:CAB12663" /db_xref="GOA:P94443" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR018309" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12220" /db_xref="UniProtKB/Swiss-Prot:P94443" /translation="MRVLKYAILGLLRKGELSGYDITSYFKEELGQFWSAKHSQIYPE LKKLTDEGFITFRTTIQGTKLEKKMYTLTDSGKQELHDWLIRHQPIPETVKDEFMLKA YFISCLSRQEASDLFKDQLQKRQAKLSDLQGSYEKLMASAEPMSFSSPDFGHYLVLTK ALEREKNYVSWLESILAMIDKD*" /label="padR CDS" gene complement(811360..811908) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /label="padR gene" S_feature complement(811909..811988) /Source="Nicolas_S_feature" /locus_tag="new_909747_909826_c" /HighExp="LoTm, Cold, G180, GM-0.2, Oxctl, T5.0H, GM 25, T3.30H, MG 60, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S285" promotor_-10 complement(811977..811996) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(811988) /Source="Nicolas_upshifts" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(812010..812015) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 812111..812114 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 812130..812149 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 812137 /Source="Nicolas_upshifts" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="upshifts" CDS 812181..812813 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11029590, 10913700, 21574267" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11029590, 10913700, 21574267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted esterase / acylglycerol lipase" /protein_id="NP_388716.1" /db_xref="EnsemblGenomes-Gn:BSU08350" /db_xref="EnsemblGenomes-Tr:CAB12664" /db_xref="GOA:Q79F14" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11951" /db_xref="UniProtKB/Swiss-Prot:Q79F14" /translation="MKKVLMAFIICLSLILSVLAAPPSGAKAESVHNPVVLVHGISGA SYNFFAIKNYLISQGWQSNKLYAIDFYDKTGNNLNNGPQLASYVDRVLKETGAKKVDI VAHSMGGANTLYYIKYLGGGNKIQNVVTLGGANGLVSSTALPGTDPNQKILYTSIYSL NDQIVINSLSRLQGARNIQLYGIGHIGLLSNSQVNGYIKEGLNGGGLNTN*" /label="estB CDS" gene 812181..812813 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /label="estB gene" downshifts 812792 /Source="Nicolas_upshifts" /id="D416" /incds=0 /nref=7 /ntot=100 /MaxReadThrough="0.87881" /MaxDrop="2.6151" /score="0.223019698" /energy="-8.5" /TU="NA" /idTUdmin="U633" /TUdmin=88 /isTUend="FALSE" /label="downshifts" promotor_-35 812928..812933 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 812947..812966 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 812957 /Source="Nicolas_upshifts" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="upshifts" CDS 813002..814090 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 24776724, 25935415, 27303652; Product type t : transporter" /codon_start=1 /transl_table=11 /product="acetyl-glucosamine metabolite exporter componentinvolved in biofilm formation" /protein_id="NP_388717.1" /db_xref="EnsemblGenomes-Gn:BSU08360" /db_xref="EnsemblGenomes-Tr:CAB12665" /db_xref="GOA:O31559" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG12893" /db_xref="UniProtKB/Swiss-Prot:O31559" /translation="MQIKEIFMIRCISCLSVVLLHIISMVLMLQAEALADISHTVDSF RTLLMFSTPAFIFISEFLLARSYPDGVPDGFLKKRGKVIFVPFLFIAAIDALLMTSAM GGEVTFLAFVQKYLANVFLGNFIGYFILVIFQFYMLHMMFHEYLKKASPKWVLSISFV VTAAYLGYFSAASPAPASEEGGAFPFFWVPFAGWLFYFCLAYYCGKEYKRFLALLNQY RWVVYGAAIASGALVVTVSYVGEIGMISSKRPDIMLYSTSMIFLCFHLFSKMKHVPKI MMFISNYSFSIYLLHAYFMIIGYVLLLNMPEIPAVPAVLLLFAVCTAGPIMTSWALNK FKYGYLFVGKIYQPKQKKVTVEVRDHAG*" /label="icaC CDS" gene 813002..814090 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /label="icaC gene" S_feature complement(813492..813880) /Source="Nicolas_S_feature" /locus_tag="new_911330_911718_c" /HighExp="S6, S8, S7, S5, LBGstat, H2O2, Mt0, Cold, G180, LPhT" /AntisenseName="yfiQ" /AntisenseCor="0.36913176163336098" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S286" upshifts complement(813880) /Source="Nicolas_upshifts" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(813882..813901) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(813914..813922) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(814126..814743) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16862575" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16862575; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388718.1" /db_xref="EnsemblGenomes-Gn:BSU08370" /db_xref="EnsemblGenomes-Tr:CAB12666" /db_xref="GOA:O31560" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1RKT" /db_xref="SubtiList:BG12894" /db_xref="UniProtKB/Swiss-Prot:O31560" /translation="MSPKVTKEHKDKRQAEILEAAKTVFKRKGFELTTMKDVVEESGF SRGGVYLYFSSTEEMFRRIIETGLDEGLRKLDKSAEHQSVWASISSYLDELTEGLRDV ADTLAPVQFEYLVTAWRNEERRQYLEKRYDLFVERFSRLLQKGIDQGEFQPVQPLATI AKFFLNMNDGIIQNALYFDEEKADVSGLAESAKLYLKTVLQADEK*" /label="yfiR CDS" gene complement(814126..814743) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /label="yfiR gene" downshifts complement(814144) /Source="Nicolas_upshifts" /id="D417" /incds=0 /nref=29 /ntot=209 /MaxReadThrough="2.44114" /MaxDrop="4.07715" /score="22.1532141" /energy="-17.1" /TU="NA" /idTUdmin="U636" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(814709..815962) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811639, 15849754, 16850406, 16862575; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388719.1" /db_xref="EnsemblGenomes-Gn:BSU08380" /db_xref="EnsemblGenomes-Tr:CAB12667" /db_xref="GOA:O31561" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12895" /db_xref="UniProtKB/Swiss-Prot:O31561" /translation="MEKPLFRNQKGLMTLLASQTISSLGDWLHILAVLTLAAFQLHAS PLDMSLLMMSFALPVIVLGPVSGLLADRFDRKTIMFLSEIGRALTVISCVYVSELWQL YVLLSVQSCFSSLFLPAKNGKLKELAPEAHIQQAVSVSSIIDNSSKIFGPALGGTLIA AFSIHSVFYINAGAFFLSAVILFFLPRDAFLQKANTPQEKTAALTSIKEGLQFLKRMP LLLTGLLTACVVLFVLQIGDSQAIILIRSFSGAPPELAGWCMAVSGAGMLLTAAITGR RRITSYLLYFSAGTLLLGLATGGAPFLSGMGIAGITLFIFAFFIMGAAFGLVHIPFQI LVQTTVPVDYSGRVFGAIQSATTLASILGMAGGGVLAEWIGVSLAFLVCGCLLIMIGL ITLIGKKIAESRRYLVTKSNKGAQG*" /label="yfiS CDS" gene complement(814709..815962) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /label="yfiS gene" promotor_-10 complement(814770..814789) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(814782) /Source="Nicolas_upshifts" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(814803..814810) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(815996..816015) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(816014) /Source="Nicolas_upshifts" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(816030..816037) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 816041..816060 /Source="Nicolas_upshift_promotors" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 816046 /Source="Nicolas_upshifts" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="upshifts" CDS 816086..816622 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15581359, 22059487, 24821014, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15581359, 22059487, 24821014, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol S-transferase" /protein_id="NP_388720.1" /db_xref="EnsemblGenomes-Gn:BSU08390" /db_xref="EnsemblGenomes-Tr:CAB12668" /db_xref="GOA:O31562" /db_xref="InterPro:IPR023774" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="PDB:1RXQ" /db_xref="SubtiList:BG12896" /db_xref="UniProtKB/Swiss-Prot:O31562" /translation="MTSVNLSYPIGEYKPRESISKEQKDKWIQVLEEVPAKLKQAVEV MTDSQLDTPYRDGGWTVRQVVHHLADSHMNSYIRFKLSLTEETPAIRPYDEKAWSELK DSKTADPSGSLALLQELHGRWTALLRTLTDQQFKRGFYHPDTKEIITLENALGLYVWH SHHHIAHITELSRRMGWS*" /label="bstA CDS" gene 816086..816622 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /label="bstA gene" CDS complement(816619..818175) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388721.1" /db_xref="EnsemblGenomes-Gn:BSU08400" /db_xref="EnsemblGenomes-Tr:CAB12669" /db_xref="GOA:O31563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12897" /db_xref="UniProtKB/Swiss-Prot:O31563" /translation="MSEALTEQKSQKWAISLFTIGVFMAALDNGIISAALTTINESFS VSPSWGSWGITLYTLGLSVSVPIVGKLSDRYGRKKLFLIEVCLFGLGSLLVALSQSFP LFLISRLIQALGGGGIFIIGSSHILATLPKEKQGKALGLLGAMNGMAAVLGPNIGSFL LDWTGSWHWLFLINLPIAVLLVVFGACFIAETKAPEAKRLDAAGIFLLSLSILAVMYG MTNLDGANLLHSLGNPEVYGCIIFGILCFAALISYEKRVEMRGGDPILAYSLLRNHMF QRTLIIGLLSGGLLAAVIFIPSYVEQYLGVPAAKAGYWMTPLALASGIGAWLGGALTD KKGPVKTVILSGIISCAGFALFPLWVTEKWEFVIASVAAGIGFGFLLGAPLNVLVSEA AKTNKGTALGTLSLVRQIGLTLAPTLYAGFITAGFDQIGDEINSRLSDSGYSEKAMQM IPEIDSSEVSSLQEQIERIPVPEVKTAISDAIHASVASGYDHLYAAAAVVSLLVIAAI SIPAFRRQKR*" /label="yfiU CDS" gene complement(816619..818175) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /label="yfiU gene" promotor_-10 complement(818197..818215) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(818214) /Source="Nicolas_upshifts" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(818231..818234) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(818286..818768) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18990441; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388722.1" /db_xref="EnsemblGenomes-Gn:BSU08410" /db_xref="EnsemblGenomes-Tr:CAB12670" /db_xref="GOA:O31564" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12898" /db_xref="UniProtKB/Swiss-Prot:O31564" /translation="MEYNLHDTTVLNENILSSEEREIWVLYMKVLTSAGLGDVSEWMK LDMSMPQMKVLMLLNNHGTLKVSDIAEKMGASLSNTTGLLDRLEKSGFVKRSHSEEDR RSVVVQLTENAKKIFRGLYEKGHLKLKRSLELLSPEEKQAVYEGLSILSRALENAKKE *" /label="yfiV CDS" gene complement(818286..818768) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /label="yfiV gene" downshifts complement(818302) /Source="Nicolas_upshifts" /id="D418" /incds=0 /nref=58 /ntot=177 /MaxReadThrough="1.47849" /MaxDrop="4.15907" /score="27.2704527" /energy="-14.2" /TU="NA" /idTUdmin="U640" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(818793..818812) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(818809) /Source="Nicolas_upshifts" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(818827..818833) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 818854..818861 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 818875..818894 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 818883 /Source="Nicolas_upshifts" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="upshifts" CDS 818940..821510 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /EC_number="2.3.2.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol lysyltransferase involved in tRNA-dependent lysinylation of phospholipids" /protein_id="YP_003097695.1" /db_xref="EnsemblGenomes-Gn:BSU08425" /db_xref="EnsemblGenomes-Tr:CAX52582" /db_xref="GOA:C0H3X7" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022791" /db_xref="InterPro:IPR024320" /db_xref="UniProtKB/Swiss-Prot:C0H3X7" /translation="MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVIN GLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFG GLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEK PWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTV IYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAI VTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAV LVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLI LPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQ ASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAII IVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDG NALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYH DFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEE LKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEIS VDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAA VIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV *" /label="mprF CDS" gene 818940..821510 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /label="mprF gene" downshifts 821481 /Source="Nicolas_upshifts" /id="D419" /incds=0 /nref=121 /ntot=252 /MaxReadThrough="1.79352" /MaxDrop="5.78159" /score="49.2396824" /energy="-16.1" /TU="NA" /idTUdmin="U641" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(821528..822505) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 19254027, 24606332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter binding lipoprotein" /protein_id="NP_388725.1" /db_xref="EnsemblGenomes-Gn:BSU08440" /db_xref="EnsemblGenomes-Tr:CAB12673" /db_xref="GOA:O31567" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12901" /db_xref="UniProtKB/Swiss-Prot:O31567" /translation="MKKHISMLFVFLMAVMVLSACNSSESSSNSEVSSSKTRTVKHAM GTSDNIPANPKRIVVLTNEGTEALLALGIKPVGAVKSWKGDPWYDYLKDDMKGVKNVG LETEPNVEAIAELKPDLIIGNKVRQEKIYDQLNAIAPTVFAESLAGNWKDNLTLYANA VNKADKGKEVIADFDKRVSDLKNKLGDQTNKTVSVVRFLSGESRIYYTDSFPGIILDQ LGFKRPEKQVELFKKQKDQFTFSTDSKESIPDMDADVLFYFTYKADNAKENEKWANQW TSSSLWKNLKAVKSGNAHEVDDVVWTTAGGIKAANYLLDDIETYFLKTK*" /label="sxzY CDS" gene complement(821528..822505) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /label="sxzY gene" downshifts complement(821539) /Source="Nicolas_upshifts" /id="D420" /incds=0 /nref=165 /ntot=248 /MaxReadThrough="1.28876" /MaxDrop="7.70135" /score="35.2605181" /energy="-16.1" /TU="NA" /idTUdmin="U643" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 822520..822527 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(822532..822551) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 822542..822561 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 822544..822635 /Source="Nicolas_S_feature" /locus_tag="new_920382_920473" /HighExp="dia0, Lbexp, LBGexp, H2O2, G150, GM 10, Oxctl, dia15, Paraq, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S287" upshifts 822544 /Source="Nicolas_upshifts" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(822549) /Source="Nicolas_upshifts" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(822566..822573) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-35" CDS 822636..823637 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388726.1" /db_xref="EnsemblGenomes-Gn:BSU08450" /db_xref="EnsemblGenomes-Tr:CAB12674" /db_xref="GOA:O31568" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12902" /db_xref="UniProtKB/Swiss-Prot:O31568" /translation="MICKKASSKWIVLVCLIFILLTAVCASVVYGYTGTSWRQVYQAF TSFNGTNEHVIIKDVRLPRALVATVVGASLAAAGALMQALTKNPLASPGIFGINAGAG FFIVAGSFFLHIQSPQALVWSSFLGAAFTAAIVYAAGSLGREGLTPIKLTLAGAAMAA MFSSLTQGLLSVNELELAQVLFWLTGSVQGRSLDLLMTMFPYAAAALVICFFLGQKIN LLVMGEDVAKGLGQKTGLLKFVMALCVVMLAGSAVAIAGPISFIGIIIPHFARFVVGN DYRWVLPFSAVLGAILLVCADIGARYIIMPQEVPVGVMTAIIGMPVFVYIARRGAKL* " /label="sxzZ CDS" gene 822636..823637 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /label="sxzZ gene" CDS 823634..824665 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388727.1" /db_xref="EnsemblGenomes-Gn:BSU08460" /db_xref="EnsemblGenomes-Tr:CAB12675" /db_xref="GOA:O31569" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12876" /db_xref="UniProtKB/Swiss-Prot:O31569" /translation="MKLRFGVTAAEKKAWIVFLVLLGLTAAVLIISAGLGQRFIPPWD VAKTFFGAGSKLDELMIMSFRMPRILTALCAGVCLAAAGAILQGLVRNPLASPDIIGI TGGAAVAVVLLMMFFSDRSSSLTISLSWLPAAAFIGASAVGLIVYLLAYKNGASTFRL VLIGIGFSMSAQAMTTLLMIKGPIYRASQANVYITGSVYGSNWQHVKIAIILSVILLF ICFVALKNMNIQVLGEDIAAGAGSAVQRNRFFLLLLSTALTGCAVSVAGTIGFVGLMA PHIARRLVGSSYGALLPASALIGALLVLTADIVGRTLFAPVEVPAGVFTAAIGAPYFI YLLYKTRNS*" /label="sxzA CDS" gene 823634..824665 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /label="sxzA gene" downshifts 824646 /Source="Nicolas_upshifts" /id="D421" /incds=0 /nref=24 /ntot=154 /MaxReadThrough="3.26686" /MaxDrop="4.27732" /score="19.6751667" /energy="-12.8" /TU="NA" /idTUdmin="U642" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 824716..824718 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 824734..824753 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 824737 /Source="Nicolas_upshifts" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 824780..825661 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /EC_number="5.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative isomerase" /protein_id="NP_388728.1" /db_xref="EnsemblGenomes-Gn:BSU08470" /db_xref="EnsemblGenomes-Tr:CAB12676" /db_xref="GOA:O31570" /db_xref="InterPro:IPR003719" /db_xref="SubtiList:BG12877" /db_xref="UniProtKB/Swiss-Prot:O31570" /translation="MKEAEVLKYEAFTSSPGKGNPAGVVLQGDDYTEDEMQIIAERAG YSETSFIRKSESADLELRYFTPGHEMNLCGHATVASLYALCEKGMLESGKTYSIQTKA GILPVKISEKDGRIHITLEQASPQFKPFTGDRKKLADALGITDEDFHEDLPIVFGSTG IWTAIVPLKSLEASKKMVPDNKQFPEVLVDLPKASVHPFTFETVHPDSDLHGRHFSSP YSGTIEDPVTGTASGVMGAYMKHYGNAEQHKFIIEQGQEIGKDGKVEIEMNEAGGHVK VNMTGTAVYSETRILKI*" /label="yfhB CDS" gene 824780..825661 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /label="yfhB gene" promotor_-35 825672..825679 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 825695..825714 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 825704 /Source="Nicolas_upshifts" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 825749..826333 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 22287527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (nitroreductase family)" /protein_id="NP_388729.1" /db_xref="EnsemblGenomes-Gn:BSU08480" /db_xref="EnsemblGenomes-Tr:CAB12677" /db_xref="GOA:O31571" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR026021" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12878" /db_xref="UniProtKB/Swiss-Prot:O31571" /translation="MPQTEQIHQHSVLRDIIRSRRSIRKFKQEPVPSAVILDMLETAK YAPNHRVTEPWRFIYVSSETGKANLINTFAAFSKKSKPDMTEEKLQNFKNTLGRVPGF LLVVFQEDENERARDDDFAATSSLIQNLQLLAWEKGIGMVWKSGKILYDKEVHQAFGL QDNERFAAIIQTGYPDEAPEVKKRTPIRDRFTEM*" /label="yfhC CDS" gene 825749..826333 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /label="yfhC gene" downshifts 826320 /Source="Nicolas_upshifts" /id="D422" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="3.27483" /MaxDrop="6.40857" /score="21.7703837" /energy="-18.2" /TU="U645" /idTUdmin="U644" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(826372..826563) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388730.1" /db_xref="EnsemblGenomes-Gn:BSU08490" /db_xref="EnsemblGenomes-Tr:CAB12678" /db_xref="InterPro:IPR025435" /db_xref="SubtiList:BG12879" /db_xref="UniProtKB/Swiss-Prot:O31572" /translation="MGRNHIHKNRDKNKQKLPQVPDALKRETDGVYEEYSTELADADD REAQERAKAADNRAKKKSR*" /label="yfhD CDS" gene complement(826372..826563) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /label="yfhD gene" downshifts complement(826390) /Source="Nicolas_upshifts" /id="D423" /incds=0 /nref=65 /ntot=197 /MaxReadThrough="0.436919999999999" /MaxDrop="8.51174" /score="30.1998663" /energy="-18.2" /TU="NA" /idTUdmin="U649" /TUdmin=7 /isTUend="TRUE" /label="downshifts" upshifts complement(826595) /Source="Nicolas_upshifts" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(826598..826609) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(826624..826630) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(826630..826740) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388731.1" /db_xref="EnsemblGenomes-Gn:BSU08500" /db_xref="EnsemblGenomes-Tr:CAB12679" /db_xref="InterPro:IPR025437" /db_xref="SubtiList:BG12880" /db_xref="UniProtKB/Swiss-Prot:O31573" /translation="MEKKREKHQQGANLKKMQEVLYSGEFKKAEKAAKRK*" /label="yfhE CDS" gene complement(826630..826740) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /label="yfhE gene" promotor_-10 complement(826769..826780) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(826771) /Source="Nicolas_upshifts" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(826795..826801) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(826795..827706) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotide-or NAD-binding protein" /protein_id="NP_388732.1" /db_xref="EnsemblGenomes-Gn:BSU08510" /db_xref="EnsemblGenomes-Tr:CAB12680" /db_xref="GOA:O31574" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR010099" /db_xref="InterPro:IPR013549" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12881" /db_xref="UniProtKB/Swiss-Prot:O31574" /translation="MNIAMTGGTGFLGQHLTGVLTRQGHHVYILSRNARETEQKNMTY VQWLSEGAAPEQELPHIDVWINLAGKSIFGRWTEKTKQHILSSRINATREVQRLIQKQ KEKPKTLIQASAVGIYGTSLEKTFTEDSATSDEDFLSHTAHLWEKEGQHIEAMGIRTV YARFGVMLGEKGALPLMILPYKFLAGGTIGTGRQWLSWIHVEDAAQMIRYAVENAGIS GPMNVTAPNPVDMKQFGKTIARVKHRPHWLPVPEFFLSKALGEMSLLIVKGQRALPKK AITSGFRFTYSDLEFALSQLIADRKTV*" /label="yfhF CDS" gene complement(826795..827706) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /label="yfhF gene" promotor_-35 827592..827595 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 827612..827631 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 827622..827794 /Source="Nicolas_S_feature" /locus_tag="new_925460_925632" /HighExp="LBGstat, Lbtran, T1.30H, T2.0H, T2.30H, M9-stat, T1.0H, T3.0H, Sw, G180" /AntisenseName="yfhF" /AntisenseCor="-5.3501479327985699E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S288" upshifts 827622 /Source="Nicolas_upshifts" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(827728..827746) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(827742) /Source="Nicolas_upshifts" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(827760..827766) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 827795..828589 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /function="16.3: Control" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8946165, 10869079, 12547390, 23284295, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8946165, 10869079, 12547390, 23284295, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulatory protein RecX" /protein_id="NP_388733.1" /db_xref="EnsemblGenomes-Gn:BSU08520" /db_xref="EnsemblGenomes-Tr:CAB12681" /db_xref="GOA:O31575" /db_xref="InterPro:IPR003783" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12882" /db_xref="UniProtKB/Swiss-Prot:O31575" /translation="MPFITKISTQKKNTERFNIFLDDKYAFSVDADVLVKFELKKGKE LDDLDIIEIQYGDEVKKGFNRALDFLSYRMRSTKEVEDHLKKKETSPPVIAEVIHRLN DYKYLNDQEFAAAYVSTHKKTNGKGPDVLFRELRAKGIDDDTIKEALSSFSFEDQTRE AVKHVEKLLKKDKKLSTKELKQRAQLQLQRKGFSFDVISAAMDQIEYENDEDTEKEAL RLHAEKAFRKYRYDGSYESAMKVKQFLFRKGFSLDLIEQLLQEEEY*" /label="recX CDS" gene 827795..828589 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /label="recX gene" CDS 828591..828905 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388734.1" /db_xref="EnsemblGenomes-Gn:BSU08530" /db_xref="EnsemblGenomes-Tr:CAB12682" /db_xref="InterPro:IPR014938" /db_xref="InterPro:IPR036289" /db_xref="PDB:1SF9" /db_xref="SubtiList:BG12883" /db_xref="UniProtKB/Swiss-Prot:O31576" /translation="MEKRYSQMTPHELNTEIALLSEKARKAEQHGIINELAVLERKIT MAKAYLLNPEDYSPGETYRVENTEDEFTISYLNGVFAWGYRTSSPQQEEALPISVLQE KE*" /label="yfhH CDS" gene 828591..828905 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /label="yfhH gene" S_feature complement(828813..829081) /Source="Nicolas_S_feature" /locus_tag="new_926651_926919_c" /HighExp="S8, S6, S5, S7, C30, S4, nit, ferm, BT, G135" /AntisenseName="yfhH" /AntisenseCor="-0.53569713251514905" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S289" downshifts 828895 /Source="Nicolas_upshifts" /id="D424" /incds=0 /nref=71 /ntot=206 /MaxReadThrough="2.93348" /MaxDrop="5.2859" /score="24.7235138" /energy="-11.6" /TU="NA" /idTUdmin="U648" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 828979..828984 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 829000..829019 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 829005 /Source="Nicolas_upshifts" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" CDS 829048..830241 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388735.1" /db_xref="EnsemblGenomes-Gn:BSU08540" /db_xref="EnsemblGenomes-Tr:CAB12683" /db_xref="GOA:O31577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12884" /db_xref="UniProtKB/Swiss-Prot:O31577" /translation="MSIKNPSVKFIIFVLMICTFSIGYTEYAVMGILTSIANDFHIQV SSAGLLVTAYAASVCLTGPLVTIISVKLPRKPVLLGLMAIFILSNLMSALAPNFAVLA ISRILSASIHGAFFAIAMVFASEMVPPEKRAAAAASMNGGLTVALMLGVPFGSYLGDV LNWRAVFSIITALGVIGFLGLMAAVPNRKPKVIPMLMNEWGVFKHKQVLFSFAITILG YSGVFIAYTFIEPILRHSAGFSTVGITGALFAYGLGGVAGNFFAGKVPLPLLTRTMIG VMIGLIGVLAVFPYIAIYPAAAIVATFLFGACAFGTPPLLQTKVISSSEGGTTIAAAV SVSAFNLANALGAWIGGMILNGTGSYSWLFAGGALMTACGLVLSTFAHLSEKKSVYEY QVNKG*" /label="yfhI CDS" gene 829048..830241 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /label="yfhI gene" S_feature 830242..830476 /Source="Nicolas_S_feature" /locus_tag="new_928080_928314" /HighExp="G180, Paraq, C30, Oxctl, H2O2, G135, G150, S8, Heat, LBGstat" /AntisenseName="sspK" /AntisenseCor="1.9886505145521101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S290" CDS complement(830274..830426) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054573.1" /db_xref="EnsemblGenomes-Gn:BSU08550" /db_xref="EnsemblGenomes-Tr:CAE01449" /db_xref="GOA:Q7WY75" /db_xref="InterPro:IPR012611" /db_xref="SubtiList:BG14175" /db_xref="UniProtKB/Swiss-Prot:Q7WY75" /translation="MVRNKEKGFPYENENKFQGEPRAKDDYASKRADGSINQHPQERM RASGKR*" /label="sspK CDS" gene complement(830274..830426) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /label="sspK gene" downshifts complement(830291) /Source="Nicolas_upshifts" /id="D425" /incds=0 /nref=24 /ntot=45 /MaxReadThrough="2.36419" /MaxDrop="4.9889" /score="20.2715496" /energy="-12.3" /TU="NA" /idTUdmin="U652" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 830455..830462 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 830476..830495 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 830478..830550 /Source="Nicolas_S_feature" /locus_tag="new_928316_928388" /HighExp="dia5, LPhT, Diami, dia15, Etha, T0.30H, H2O2, LBGstat, BC, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S291" upshifts 830478 /Source="Nicolas_upshifts" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(830485..830496) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(830495) /Source="Nicolas_upshifts" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(830511..830517) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 830551..830820 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388736.1" /db_xref="EnsemblGenomes-Gn:BSU08560" /db_xref="EnsemblGenomes-Tr:CAB12684" /db_xref="InterPro:IPR026952" /db_xref="SubtiList:BG12885" /db_xref="UniProtKB/Swiss-Prot:O31578" /translation="MNMYIEKLTNLLLEKNEMISYIQAKTWVELLWSDFEATYAKAGH AYQGEKMTEKIVTQWIENYGGQLHLFQSSRNDVNDYLNQSRGLLH*" /label="yfhJ CDS" gene 830551..830820 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /label="yfhJ gene" downshifts 830809 /Source="Nicolas_upshifts" /id="D426" /incds=0 /nref=62 /ntot=233 /MaxReadThrough="2.9538" /MaxDrop="5.3621" /score="19.3423239" /energy="-10.6" /TU="NA" /idTUdmin="U650" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 830898..830904 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 830919 /Source="Nicolas_upshifts" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 830920..830938 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 830965..831483 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388737.1" /db_xref="EnsemblGenomes-Gn:BSU08570" /db_xref="EnsemblGenomes-Tr:CAB12685" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12886" /db_xref="UniProtKB/Swiss-Prot:O31579" /translation="MKKKQVMLALTAAAGLGLTALHSAPAAKAAPLHDISVSMPSSDT YIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDRFVNADWAQIHFKGKKAYISTHFLM KTASQAKTTKQTAFYTPTPENGKAKQLSSGTEVTILGWGFSENGGFDFTWAFVDYGGV KGYIHTKDLQMR*" /label="yfhK CDS" gene 830965..831483 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /label="yfhK gene" S_feature 831484..831551 /Source="Nicolas_S_feature" /locus_tag="new_929322_929389" /HighExp="Etha, Sw, Salt, M9-stat, B60, B36, Gly, LoTm, BC, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S292" promotor_-35 831519..831528 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-35" promotor_-10 831540..831555 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-10" upshifts 831553 /Source="Nicolas_upshifts" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="upshifts" CDS 831568..831900 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor for peptide SdpC immunity" /protein_id="NP_388738.1" /db_xref="EnsemblGenomes-Gn:BSU08580" /db_xref="EnsemblGenomes-Tr:CAB12686" /db_xref="GOA:O31580" /db_xref="InterPro:IPR025962" /db_xref="SubtiList:BG12887" /db_xref="UniProtKB/Swiss-Prot:O31580" /translation="MTGLVGGGLMIIAGILIKLFPPKSINSVYGYRTRRSMSDQRLWN EANRYSASLMILSGLVIAGMGLLLGSNLFILQLILLIAACVITFMLTEKRLKIMTHSQ GGDRSGRS*" /label="spdL CDS" gene 831568..831900 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /label="spdL gene" CDS 831887..832747 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /EC_number="3.3.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16597997, 20941576" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16597997, 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stress induced epoxide hydrolase" /protein_id="NP_388739.1" /db_xref="EnsemblGenomes-Gn:BSU08590" /db_xref="EnsemblGenomes-Tr:CAB12687" /db_xref="GOA:O31581" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12888" /db_xref="UniProtKB/Swiss-Prot:O31581" /translation="MDGVKCQFVNTNGITLHVAAAGREDGPLIVLLHGFPEFWYGWKN QIKPLVDAGYRVIAPDQRGYNLSDKPEGIDSYRIDTLRDDIIGLITQFTDEKAIVIGH DWGGAVAWHLASTRPEYLEKLIAINIPHPHVMKTVTPLYPPQWLKSSYIAYFQLPDIP EASLRENDYDTLDKAIGLSDRPALFTSEDVSRYKEAWKQPGALTAMLNWYRALRKGSL AEKPSYETVPYRMIWGMEDRFLSRKLAKETERHCPNGHLIFVDEASHWINHEKPAIVN QLILEYLKNQ*" /label="ephM CDS" gene 831887..832747 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /label="ephM gene" downshifts 832745 /Source="Nicolas_upshifts" /id="D427" /incds=0 /nref=27 /ntot=191 /MaxReadThrough="5.0793" /MaxDrop="4.1326" /score="3.7712168" /energy="-8.4" /TU="U653,U654" /idTUdmin="U654" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 832805..832811 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 832825..832836 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 832833..832897 /Source="Nicolas_S_feature" /locus_tag="new_930671_930735" /HighExp="Etha, S5, M9-stat, T0.30H, Sw, T-0.40H, B60, S8, B36, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S293" upshifts 832833 /Source="Nicolas_upshifts" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(832855..832874) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(832864) /Source="Nicolas_upshifts" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 832880..832886 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(832888..832889) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 832899..832979 /Source="Nicolas_S_feature" /locus_tag="new_930737_930817" /HighExp="M9-stat, LBGexp, Lbexp, T0.30H, dia0, T1.30H, T1.0H, LBGtran, Paraq, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF, SigB" /TUshortPSig="1, 0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S294" upshifts 832899 /Source="Nicolas_upshifts" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 832901..832919 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 832980..833969 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /EC_number="2.4.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8921856, 9636707, 23632331; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bactoprenol glycosyl transferase, phageorigin" /protein_id="NP_388740.1" /db_xref="EnsemblGenomes-Gn:BSU08600" /db_xref="EnsemblGenomes-Tr:CAB12688" /db_xref="GOA:Q45539" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11834" /db_xref="UniProtKB/Swiss-Prot:Q45539" /translation="MKQGLISIIIPSYNEGYNVKLIHESLKKEFKNIHYDYEIFFIND GSVDDTLQQIKDLAATCSRVKYISFSRNFGKEAAILAGFEHVQGEAVIVMDADLQHPT YLLKEFIKGYEEGYDQVIAQRNRKGDSFVRSLLSSMYYKFINKAVEVDLRDGVGDFRL LSRQAVNALLKLSEGNRFSKGLFCWIGFDQKIVFYENVERKNGTSKWSFSSLFNYGMD GVVSFNHKPLRLCFYTGIFILLLSIIYIIATFVKILTNGISVPGYFTIISAVLFLGGV QLLSLGIIGEYIGRIYYETKKRPHYLIKEANIPNKDLPETNELKSMRRLTKMH*" /label="csbB CDS" gene 832980..833969 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /label="csbB gene" upshifts complement(833129) /Source="Nicolas_upshifts" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(833134..833138) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(833155..833159) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 833970..834040 /Source="Nicolas_S_feature" /locus_tag="new_931808_931878" /HighExp="LPhT, Heat, Etha, LBGexp, M9-stat, LBGtran, Lbexp, Sw, dia0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigB" /TUshortPSig="1, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S295" CDS 834041..836626 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23632331; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388741.2" /db_xref="EnsemblGenomes-Gn:BSU08610" /db_xref="EnsemblGenomes-Tr:CAB12689" /db_xref="GOA:O31582" /db_xref="InterPro:IPR018580" /db_xref="SubtiList:BG12889" /db_xref="UniProtKB/Swiss-Prot:O31582" /translation="MKRKHIMIYAASLLVSVLAHAFFVKEWAEGRYMTGPGDGLAQMI VFKKLLFDQYTHGNFFYNYSFGLGGGTFSQLGYYFSASFLFLAVSAAVWLLQAVQLIG ETDTLFWAESAVFISIFKLSLIIFTSASVFHYLLKHRAASFTGAVLYGVSIIYFRHEA YWEFFTDTMVWLPLLVLGAEKIIRERRPAWFIVACSLTLINNFYFAYINLIFIGIYVL FRWLIRLEPHEEKRWIQIRLFLVSGFISFGISAAAFVPVVYGFLNNLRPPYSQKIEWL NFDDNILFSSRIIIVPAAFLLFLFIISFYKNRVFRLFAGLSLLFILFHFSPYAASVFN GFSAPQNRFEYVLAFTIAGAAAAGLSQLSELKRKELLPAAAVVLLLYLYHIQRYKLDI WKPANESILLLLLMTIAALFAAAFAKKRAKMAVYGIIILSSLFVANSYQKYALSEGGD LDSVTKEYLTSEEYRGRESSELIRRLQKEDDDPLMRIDWMNGVRNNTPIIYGFNGFSA YSSILNKDLLAFYWNDLSIDMGRESVSRYASLGDRANLYSLLYGKYYMTEKTNEASVP YGFKKHLETEHYAVYENQYMLPFVKTADAIYSESELDRLPALAKEQAMLKGIILKDPS GKTEQTPKPSNLITKSDITAKQAQYQNGLLTVTGENGGELIITPKQPSSAPGDYYVSF YLKSKAKDKGFTLKVNDYVTTRKSNKSIYKTGVNNITVRVPKSGHISINLPKGTYELR NIALYEENYQTLKNAVMQNKTEKADKLNWNKNRLTFSYHLSKDQYIMLPIPYEKGWEL KINGKTQKIEKADYAFIGFKAQKGDNHIELTYYPPYFKISAIISLVSLLLAVFYIRRK KPGSI*" /label="yfhO CDS" gene 834041..836626 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /label="yfhO gene" downshifts 836595 /Source="Nicolas_upshifts" /id="D428" /incds=0 /nref=63 /ntot=217 /MaxReadThrough="2.13267" /MaxDrop="4.17784" /score="2.41489488" /energy="-13.3" /TU="NA" /idTUdmin="U657" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(836619..837602) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10463184, 10524235, 15849754, 16850406, 24237659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_388742.1" /db_xref="EnsemblGenomes-Gn:BSU08620" /db_xref="EnsemblGenomes-Tr:CAB12690" /db_xref="GOA:O31583" /db_xref="InterPro:IPR007404" /db_xref="SubtiList:BG12890" /db_xref="UniProtKB/Swiss-Prot:O31583" /translation="MDTGTHVVMGIALGGIATLDPVVGSDPAMAHAVMIATLAGSQAP DIDTVLKLKNNAVYIRNHRGFTHSIPAVLFWSVIIPAILYLFYPQADFLHLWLWTLLA VVLHVFVDIFNAYGTQAIRPFSKKWVALGLINTFDPFIFISHLAAIAIWYAGGSPGIT FLSLYIILVGYYLVRLIMQLRIKRKLHEMIHDEIESIIISPTMKFRQWRIAVTTAHAF YVGRSMEGHVVILDTFNRVPVPETDVMHAAKQDDNIAAFLSFSPVYRWEVDTFKDHYE VRFIDLRYRSKGHYPFVAIVHIGHDLTIRSSYTGWIFSEEKLQKKLKLGSI*" /label="yfhP CDS" gene complement(836619..837602) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /label="yfhP gene" downshifts complement(836653) /Source="Nicolas_upshifts" /id="D429" /incds=0 /nref=28 /ntot=200 /MaxReadThrough="2.65266" /MaxDrop="4.43244" /score="25.5564412" /energy="-17.5" /TU="NA" /idTUdmin="U661" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 837076..837085 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 837098..837117 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 837102 /Source="Nicolas_upshifts" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(837603..837750) /Source="Nicolas_S_feature" /locus_tag="new_935441_935588_c" /HighExp="Diami, dia15, M9-stat, dia5, Etha, H2O2, S6, Salt, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S296" promotor_-35 837707..837711 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 837727..837746 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 837734 /Source="Nicolas_upshifts" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 837740..837817 /Source="Nicolas_S_feature" /locus_tag="new_935578_935655" /HighExp="H2O2, G150, G180, LBGstat, dia15, Diami, Oxctl, Paraq, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S297" promotor_-10 complement(837748..837767) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(837750) /Source="Nicolas_upshifts" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(837782..837789) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 837818..838927 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /EC_number="3.2.2.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10463184, 20971907, 21954439, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10463184, 20971907, 21954439, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="A/G-specific adenine glycosylase or DNA-(apurinic or apyrimidinic site) lyase" /protein_id="NP_388743.1" /db_xref="EnsemblGenomes-Gn:BSU08630" /db_xref="EnsemblGenomes-Tr:CAB12691" /db_xref="GOA:O31584" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR005760" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR029119" /db_xref="SubtiList:BG12891" /db_xref="UniProtKB/Swiss-Prot:O31584" /translation="MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWV SEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAV KEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSI WDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCS AFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLET QKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSK LKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP*" /label="mutY CDS" gene 837818..838927 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /label="mutY gene" promotor_-35 838764..838768 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 838784..838803 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 838796 /Source="Nicolas_upshifts" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 838928..839240 /Source="Nicolas_S_feature" /locus_tag="new_936766_937078" /HighExp="H2O2, G150, dia15, G135, G180, Oxctl, Paraq, dia0, LBGexp, Lbexp" /AntisenseName="yfhS" /AntisenseCor="-0.72611377663365595" /AntisenseRegPval="-44.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S298" CDS complement(838935..839159) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10463184" /codon_start=1 /transl_table=11 /product="conserved protein related to sporulation" /protein_id="NP_388744.1" /db_xref="EnsemblGenomes-Gn:BSU08640" /db_xref="EnsemblGenomes-Tr:CAB12692" /db_xref="SubtiList:BG12892" /db_xref="UniProtKB/Swiss-Prot:O31585" /translation="MYVGRDMSELNMVSKKDWKNSELAYFHHAFQQIMPYLNEEGQSK YRELTQEIEARGGMKRNEADYSHGTRVSYD*" /label="yfhS CDS" gene complement(838935..839159) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /label="yfhS gene" promotor_-10 complement(839189..839200) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(839191) /Source="Nicolas_upshifts" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(839214..839220) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 839241..839993 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /EC_number="1.3.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 12440970, 17329825, 21185310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 12440970, 17329825, 21185310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase III" /protein_id="NP_388745.1" /db_xref="EnsemblGenomes-Gn:BSU08650" /db_xref="EnsemblGenomes-Tr:CAB12693" /db_xref="GOA:P71079" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIC" /db_xref="PDB:3OID" /db_xref="SubtiList:BG12221" /db_xref="UniProtKB/Swiss-Prot:P71079" /translation="MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALE TAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELE ETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAA LEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIK DMVDTVEFLVSSKADMIRGQTIIVDGGRSLLV*" /label="fabL CDS" gene 839241..839993 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /label="fabL gene" promotor_-35 840010..840016 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 840031..840042 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 840032 /Source="Nicolas_upshifts" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(840039..840053) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(840060) /Source="Nicolas_upshifts" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(840062..840066) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 840062..840316 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1744043, 7592342, 9540829, 19542328, 23314362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744043, 7592342, 9540829, 19542328, 23314362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (gamma-type SASP)" /protein_id="NP_388746.1" /db_xref="EnsemblGenomes-Gn:BSU08660" /db_xref="EnsemblGenomes-Tr:CAB12694" /db_xref="GOA:P07784" /db_xref="InterPro:IPR006341" /db_xref="SubtiList:BG10789" /db_xref="UniProtKB/Swiss-Prot:P07784" /translation="MANSNNFSKTNAQQVRKQNQQSAAGQGQFGTEFASETNAQQVRK QNQQSAGQQGQFGTEFASETDAQQVRQQNQSAEQNKQQNS*" /label="sspE CDS" gene 840062..840316 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /label="sspE gene" downshifts 840314 /Source="Nicolas_upshifts" /id="D430" /incds=0 /nref=261 /ntot=269 /MaxReadThrough="1.59207" /MaxDrop="8.74804" /score="9.25353719" /energy="-9.5" /TU="NA" /idTUdmin="U660" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(840339) /Source="Nicolas_upshifts" /id="D431" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.21036" /MaxDrop="5.14076" /score="-9.78320441" /energy="-7.1" /TU="NA" /idTUdmin="U663" /TUdmin="-1687" /isTUend="FALSE" /label="downshifts" CDS 840405..840749 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388747.1" /db_xref="EnsemblGenomes-Gn:BSU08670" /db_xref="EnsemblGenomes-Tr:CAB12695" /db_xref="InterPro:IPR025572" /db_xref="SubtiList:BG12222" /db_xref="UniProtKB/Swiss-Prot:P71080" /translation="MSQRVCFMEIEMIKGGNVYTFIRLKEEPMTEFEKLVSEQMKTMD KLLDLQSELDRCKQIEAELRHLERDARLRGIQAEIAVKRKHLADIQDMFQKQTEQVIR SYRSSEKPSSFV*" /label="ygaB CDS" gene 840405..840749 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /label="ygaB gene" promotor_-35 840412..840420 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 840431..840449 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 840433 /Source="Nicolas_upshifts" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="upshifts" downshifts 840732 /Source="Nicolas_upshifts" /id="D432" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.84572" /MaxDrop="3.29993" /score="13.9694142" /energy="-11.5" /TU="U666" /idTUdmin="U660" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 840788..840795 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 840809..840828 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 840818..840892 /Source="Nicolas_S_feature" /locus_tag="new_938656_938730" /HighExp="Etha, dia15, dia5, Diami, Salt, H2O2, BC, T5.0H, Cold, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S299" upshifts 840818 /Source="Nicolas_upshifts" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="upshifts" CDS 840893..841423 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19383706, 22333191; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding factor" /protein_id="NP_388748.3" /db_xref="EnsemblGenomes-Gn:BSU08680" /db_xref="EnsemblGenomes-Tr:CAB12696" /db_xref="InterPro:IPR007295" /db_xref="InterPro:IPR016882" /db_xref="InterPro:IPR035930" /db_xref="SubtiList:BG12223" /db_xref="UniProtKB/Swiss-Prot:Q796Z1" /translation="MGYPKEGETIQIHSYKHNGLIHRIWNETTILKSTEMCVIGANDR TMVTESDGRTWITREPAICYFHARQWFNVIGMLREDGVHYYCNISSPFAYDGEAIKYI DYDLDVKVFPDMTYNILDEDEYDDHRKAMNYPKEIDSILRDYLNTLLHWIHQRQGPFA PEFVDMWYERYLRYTK*" /label="ygaC CDS" gene 840893..841423 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /label="ygaC gene" downshifts 841414 /Source="Nicolas_upshifts" /id="D433" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="6.10669" /MaxDrop="3.97335" /score="-5.22328881" /energy="-7" /TU="U667" /idTUdmin="U666" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 841511..843253 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388749.2" /db_xref="EnsemblGenomes-Gn:BSU08690" /db_xref="EnsemblGenomes-Tr:CAB12697" /db_xref="GOA:P71082" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12224" /db_xref="UniProtKB/Swiss-Prot:P71082" /translation="MGVMKRYMQFVKPYKKQIFVTVLIGIVKFSIPLALPLLLKYVVD DIIQGGGTASDKTTSLFTIMAIMFALFLILRPPVEYYRQYFAQWTASKVLYDIRAKLF DHIQKLSLRFYANTRTGEVISRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTL DVKLTLISIVLFPLYGISVKYFYGRLRKLTRERSQALAQVQGHLHERIQGMPVIRSFA IEDHEQAQFNEKNGHFLDKAIRHTNWNAKTFAVVNTITDLAPLIVIACAGYFVINGPL TVGTMVAFVGYIDRMYNPVRRLINSSTTLTQSIASMDRVFEFIDEPYELTDKPNAIKA DQIRGGVEFQNVSFQYEKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFY DVTSGRLLIDGTDIRDYEARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATLEEIIE AAKAANAHEFIMSFPEGYETRVGERGVKLSGGQKQRISIARVFLKNPPLLILDEATSA LDLESEHYIQEAMDKLAKDRTTFVVAHRLSTITHADKIVVMENGTIIEIGTHDELMDY ESQYKHLFTIQNLN*" /label="ygaD CDS" gene 841511..843253 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /label="ygaD gene" downshifts 843240 /Source="Nicolas_upshifts" /id="D434" /incds=0 /nref=87 /ntot=233 /MaxReadThrough="2.54676" /MaxDrop="5.20475" /score="22.3853226" /energy="-14.1" /TU="NA" /idTUdmin="U667" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(843330..844391) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388750.1" /db_xref="EnsemblGenomes-Gn:BSU08700" /db_xref="EnsemblGenomes-Tr:CAB12698" /db_xref="GOA:P71083" /db_xref="InterPro:IPR010343" /db_xref="SubtiList:BG12225" /db_xref="UniProtKB/Swiss-Prot:P71083" /translation="MKLGARIFKTGIAITLALYLASWIGLPAPIFAGIAAIFAIQPSI YRSFLIIIDQVQANIIGAVIATVFGLIFGPSPIMIGLTAVIVITIMLKLKIEHTISIA LVTVIAILESAGDDFLMFALIRTSTVILGVLSSFIVNLVFLPPKYETKLIHNTVENTE EIMKWIRLSMRQSTEHSILKEDIEKLKEKMIKLDQTYLLYKEERSYFKKTTYVKSRKL VLFRQAIITANRALDTLKKLHRLENEIYHMPEEFQETLTEELDYLLYWHERILMRFVG KIKPHDDAVEEGIRYKQLLTKSFLKNQQNTDEELIDYNMLNIMASAVEYREQLEHLET LITSFQTYHPKDCEIETEE*" /label="ygaE CDS" gene complement(843330..844391) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /label="ygaE gene" downshifts complement(843341) /Source="Nicolas_upshifts" /id="D435" /incds=0 /nref=181 /ntot=254 /MaxReadThrough="1.1413" /MaxDrop="7.13599" /score="26.0617552" /energy="-9.4" /TU="NA" /idTUdmin="U668" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature complement(844392..844482) /Source="Nicolas_S_feature" /locus_tag="new_942230_942320_c" /HighExp="G180, Oxctl, Paraq, C30, G150, LBGexp, LPhT, S4, G135, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S300" promotor_-10 complement(844480..844499) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(844489) /Source="Nicolas_upshifts" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(844514..844521) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(844611..845900) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231799, 19930658; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde aminotransferase, classIII aminotransferase" /protein_id="NP_388751.3" /db_xref="EnsemblGenomes-Gn:BSU08710" /db_xref="EnsemblGenomes-Tr:CAB12699" /db_xref="GOA:P71084" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11943" /db_xref="UniProtKB/Swiss-Prot:P71084" /translation="MHTKSIELHNEALQHIVGGVNSPSRSYKAVGGGSPVAMEKASGA YFWDVDGNKYIDYLAAYGPIITGHAHPHITEAIKKAAENGVLYGTPTKHEVTFAKMLK EAIPAMDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPS TLGTPDSAGVPKSIANEVITVPFNDIDSYKAALEKWGSEIAAVLVEPIVGNFGIVEPK EGFLEQVNELTHNAGALVIYDEVITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIG AYGGKQEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKEKGVYEKLDHLGAMLE EGILKHAETHGITITVNRLKGALTVYFSDEKVENYEQAERSDGETFSTFFKLMLERGI NLAPSKYEAWFITTAHTEQDIKDTLTAVEDAFKHLKN*" /label="gsaB CDS" gene complement(844611..845900) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /label="gsaB gene" downshifts complement(844614) /Source="Nicolas_upshifts" /id="D436" /incds=0 /nref=235 /ntot=258 /MaxReadThrough="2.54961" /MaxDrop="5.8522" /score="29.5551149" /energy="-11" /TU="NA" /idTUdmin="U669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(845928..845947) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(845947) /Source="Nicolas_upshifts" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(845949..846660) /Source="Nicolas_S_feature" /locus_tag="new_943787_944498_c" /HighExp="LoTm, M9-stat, B60, S8, C30, Cold, B36, T1.30H, Etha, T2.0H" /AntisenseName="ygaF" /AntisenseCor="-0.29702219161000198" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S301" promotor_-35 complement(845959..845964) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 845993..846000 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 846014..846033 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 846014 /Source="Nicolas_upshifts" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="upshifts" CDS 846053..846526 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /EC_number="1.11.1.15" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10644761, 11349039, 12950915, 21910476, 26723255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin with versatile activity" /protein_id="YP_054574.1" /db_xref="EnsemblGenomes-Gn:BSU08720" /db_xref="EnsemblGenomes-Tr:CAB12700" /db_xref="GOA:Q796Y8" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12226" /db_xref="UniProtKB/Swiss-Prot:Q796Y8" /translation="MTIEIGQKAPDLELKGDHGETVKLSDYKGKYIVLYFYPKDMTPG CTTEACDFRDSHESFAELDAVIIGVSPDSQEKHGKFKEKHNLPFLLLVDDEHKLAEAF DVWKLKKNFGKEYMGIERSTFLIDKEGRLIKEWRKVKVKDHVAEALQTLKDMSEK*" /label="bcp CDS" gene 846053..846526 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /label="bcp gene" promotor_-35 846563..846570 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 846585..846604 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 846591 /Source="Nicolas_upshifts" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="upshifts" CDS 846649..847086 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1580225, 16541078, 16925555, 22194458, 27935957, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1580225, 16541078, 16925555, 22194458, 27935957, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Fur family)" /protein_id="NP_388753.1" /db_xref="EnsemblGenomes-Gn:BSU08730" /db_xref="EnsemblGenomes-Tr:CAB12701" /db_xref="GOA:P71086" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FE3" /db_xref="PDB:2RGV" /db_xref="PDB:3F8N" /db_xref="SubtiList:BG12227" /db_xref="UniProtKB/Swiss-Prot:P71086" /translation="MAAHELKEALETLKETGVRITPQRHAILEYLVNSMAHPTADDIY KALEGKFPNMSVATVYNNLRVFRESGLVKELTYGDASSRFDFVTSDHYHAICENCGKI VDFHYPGLDEVEQLAAHVTGFKVSHHRLEIYGVCQECSKKENH*" /label="perR CDS" gene 846649..847086 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /label="perR gene" downshifts 847068 /Source="Nicolas_upshifts" /id="D437" /incds=0 /nref=149 /ntot=247 /MaxReadThrough="3.98479" /MaxDrop="7.52234" /score="1.62878623" /energy="-12.3" /TU="U670,U671" /idTUdmin="U670" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(847121..847474) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_054575.1" /db_xref="EnsemblGenomes-Gn:BSU08740" /db_xref="EnsemblGenomes-Tr:CAE01450" /db_xref="GOA:Q7WY74" /db_xref="InterPro:IPR020912" /db_xref="SubtiList:BG14192" /db_xref="UniProtKB/Swiss-Prot:Q7WY74" /translation="MAKYSSKINKIRTFALSLVFVGFIIMYIGIFFKESVLLSSLFMI LGLLSIGLSTVVYFWIGMLSTKAVRVICPGCDKETKVLGVVDMCMHCREPLTLDKGLE GKEFDESYNKKKMSK*" /label="ygzB CDS" gene complement(847121..847474) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /label="ygzB gene" downshifts 847134 /Source="Nicolas_upshifts" /id="D438" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="2.62283" /MaxDrop="4.13562" /score="-4.23596421" /energy="-12.5" /TU="NA" /idTUdmin="U670" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(847144) /Source="Nicolas_upshifts" /id="D439" /incds=0 /nref=182 /ntot=253 /MaxReadThrough="4.02571" /MaxDrop="6.23378" /score="9.51667757" /energy="-14.2" /TU="NA" /idTUdmin="U673" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 847470..847474 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-35" promotor_-10 847482..847496 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-10" misc_feature complement(847486..847505) /Source="Nicolas_upshift_promotors" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 847486..847577 /Source="Nicolas_S_feature" /locus_tag="new_945324_945415" /HighExp="Cold, C30, H2O2, Etha, dia15, G135, Paraq, C90, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S302" upshifts 847486 /Source="Nicolas_upshifts" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="upshifts" upshifts complement(847496) /Source="Nicolas_upshifts" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 847554..847557 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-35" promotor_-10 847572..847591 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-10" S_feature 847579..847681 /Source="Nicolas_S_feature" /locus_tag="new_945417_945519" /HighExp="BMM, Cold, LBGstat, C30, Oxctl, LBGexp, Paraq, G180, Lbexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.996, 0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S303" upshifts 847579 /Source="Nicolas_upshifts" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="upshifts" CDS 847682..848566 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388755.1" /db_xref="EnsemblGenomes-Gn:BSU08750" /db_xref="EnsemblGenomes-Tr:CAB12703" /db_xref="InterPro:IPR029348" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10951" /db_xref="UniProtKB/Swiss-Prot:Q04385" /translation="MENLLRPIYQERASHPNTLAVIMIERRNKTSSLTDNFDAALLVI VKDADEPVFIKHYEFDHQTASLHVVTDSQIQEWILLGTNRRIIDWIVNGRVLFDRNEY VVELIDRLNTFPFAERKLKIGLEYGKLIRRYVEGKAFFEANQFLDAYNAVVHALHHLA RIEVIDRGFHPETTVWSQVRQMEPQVYKLYSELIESHESLEKRLELLFLANDFLIHSK AEIGSAHLFEVMKEKDIWQFGELLQHHDLKHFTQDLGVMLDYLTEKGLINVCQIETKG QAVYHRGYSFKKGVDSDS*" /label="ygxA CDS" gene 847682..848566 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /label="ygxA gene" promotor_-35 848549..848556 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 848570..848589 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 848585..848857 /Source="Nicolas_S_feature" /locus_tag="new_946423_946695" /HighExp="LBGstat, Oxctl, C30, Paraq, GM 120, H2O2, HPh, G150, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.106881" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="Sig-" /TUlongPSig="0.0739" /label="S304" upshifts 848585 /Source="Nicolas_upshifts" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(848618) /Source="Nicolas_upshifts" /id="D440" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="2.70619" /MaxDrop="3.85046" /score="4.43428373" /energy="-7.8" /TU="NA" /idTUdmin="U673" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" rRNA 848858..850412 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-16S rRNA" gene 848858..850412 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /label="rrnD-16S gene" rRNA 850580..853507 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-23S rRNA" gene 850580..853507 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /label="rrnD-23S gene" S_feature 853508..853593 /Source="Nicolas_S_feature" /locus_tag="new_951346_951431" /HighExp="G135, C30, Oxctl, Paraq, LBGstat, dia0, HiTm, Fru, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S305" promotor_-35 853569..853576 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 853590..853609 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 853595 /Source="Nicolas_upshifts" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="upshifts" rRNA 853619..853734 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-5S rRNA" gene 853619..853734 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /label="rrnD-5S gene" tRNA 853744..853818 /gene="asnTA" /locus_tag="BSU_tRNA_29" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="asparagine transfer RNA (GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="asnTA tRNA" gene 853744..853818 /gene="asnTA" /locus_tag="BSU_tRNA_29" /label="asnTA gene" tRNA 853824..853915 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Ser tRNA" gene 853824..853915 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /label="trnD-Ser gene" downshifts 853911 /Source="Nicolas_upshifts" /id="D441" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="7.64297" /MaxDrop="4.37505" /score="-9.7424199" /energy="-11" /TU="U676" /idTUdmin="U677" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" tRNA 853950..854021 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Glu tRNA" gene 853950..854021 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /label="trnD-Glu gene" tRNA 854031..854106 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Val tRNA" gene 854031..854106 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /label="trnD-Val gene" tRNA 854116..854192 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Met tRNA" gene 854116..854192 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /label="trnD-Met gene" tRNA 854204..854280 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Asp tRNA" gene 854204..854280 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /label="trnD-Asp gene" tRNA 854293..854368 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Phe(GAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Phe tRNA" gene 854293..854368 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /label="trnD-Phe gene" tRNA 854374..854446 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Thr tRNA" gene 854374..854446 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /label="trnD-Thr gene" tRNA 854469..854553 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GUA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Tyr tRNA" gene 854469..854553 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /label="trnD-Tyr gene" tRNA 854559..854632 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /product="tRNA-Trp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Trp(CCA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Trp tRNA" gene 854559..854632 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /label="trnD-Trp gene" tRNA 854657..854732 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="transfer RNA-His(GUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-His tRNA" gene 854657..854732 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /label="trnD-His gene" tRNA 854742..854813 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Gln tRNA" gene 854742..854813 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /label="trnD-Gln gene" tRNA 854863..854937 /gene="glyTB" /locus_tag="BSU_tRNA_41" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="glycine transfer RNA (GCC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="glyTB tRNA" gene 854863..854937 /gene="glyTB" /locus_tag="BSU_tRNA_41" /label="glyTB gene" tRNA 854943..855013 /gene="cysTA" /locus_tag="BSU_tRNA_42" /product="tRNA-Cys" /inference="profile:tRNAscan:1.23" /note="cysteine tRNA (GCA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="cysTA tRNA" gene 854943..855013 /gene="cysTA" /locus_tag="BSU_tRNA_42" /label="cysTA gene" tRNA 855021..855109 /gene="leuTA" /locus_tag="BSU_tRNA_43" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine RNA (UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTA tRNA" gene 855021..855109 /gene="leuTA" /locus_tag="BSU_tRNA_43" /label="leuTA gene" S_feature 855110..855186 /Source="Nicolas_S_feature" /locus_tag="new_952948_953024" /HighExp="Paraq, C30, Oxctl, G180, G135, Heat, BMM, LBGexp, dia15, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S306" downshifts 855143 /Source="Nicolas_upshifts" /id="D442" /incds=0 /nref=18 /ntot=231 /MaxReadThrough="5.36857" /MaxDrop="5.05259" /score="16.6649124" /energy="-8.9" /TU="U676" /idTUdmin="U677" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature 855188..855356 /Source="Nicolas_S_feature" /locus_tag="new_953026_953194" /HighExp="Heat, Paraq, BMM, Oxctl, H2O2, Cold, G180, Pyr, C30, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S307" promotor_-35 855313..855320 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 855319 /Source="Nicolas_upshifts" /id="D443" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.84674" /MaxDrop="3.439" /score="35.1424037" /energy="-12.4" /TU="U676" /idTUdmin="U677" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 855334..855353 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 855358 /Source="Nicolas_upshifts" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="upshifts" tRNA 855375..855456 /gene="leuTB" /locus_tag="BSU_tRNA_44" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine tRNA(CAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTB tRNA" gene 855375..855456 /gene="leuTB" /locus_tag="BSU_tRNA_44" /label="leuTB gene" promotor_-10 complement(855392..855409) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(855395) /Source="Nicolas_upshifts" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(855430..855435) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(855465) /Source="Nicolas_upshifts" /id="D444" /incds=0 /nref=5 /ntot=151 /MaxReadThrough="1.64364" /MaxDrop="6.28675" /score="7.71223568" /energy="-12.4" /TU="NA" /idTUdmin="U679" /TUdmin=18 /isTUend="TRUE" /label="downshifts" CDS complement(855535..856311) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9795118, 22142536, 26625291, 28234965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9795118, 22142536, 26625291, 28234965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="protein involved in the control of the cell cycle as a function of the environment" /protein_id="NP_388756.2" /db_xref="EnsemblGenomes-Gn:BSU08760" /db_xref="EnsemblGenomes-Tr:CAB12704" /db_xref="GOA:P71088" /db_xref="InterPro:IPR009776" /db_xref="InterPro:IPR014756" /db_xref="PDB:5CL2" /db_xref="SubtiList:BG12229" /db_xref="UniProtKB/Swiss-Prot:P71088" /translation="MSFFKKLAASAGIGAAKVDTILEKDAYFPGEEVQGTVHVKGGKI AQDIRYIDLQLSTRYVIVKDDEEHRKYATIHSFRVTGSFTIQPGEEHQFPFTFTLPLD TPITVGKVEVAVVTDLDIQGGIDKSDHDRIFVEAHPWIENVLEAIENLGFRLNEADCE QAPYFQRRLPFVQEFEFVPTSGYYRQMLDELELIFLLDEDGLEIIFEVDRRARGLRGW LEEMYNDGEQLVRVRFSQSELEDTEELEEVLEEILDQYAE*" /label="spo0M CDS" gene complement(855535..856311) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /label="spo0M gene" downshifts complement(855549) /Source="Nicolas_upshifts" /id="D445" /incds=0 /nref=9 /ntot=131 /MaxReadThrough="6.06864" /MaxDrop="6.58787" /score="6.75662782" /energy="-7" /TU="U679" /idTUdmin="U679" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(856338..856353) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(856360) /Source="Nicolas_upshifts" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(856366..856375) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 856395..856401 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 856416..856427 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 856419 /Source="Nicolas_upshifts" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="upshifts" CDS 856453..856656 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388757.2" /db_xref="EnsemblGenomes-Gn:BSU08770" /db_xref="EnsemblGenomes-Tr:CAB12705" /db_xref="SubtiList:BG12981" /db_xref="UniProtKB/Swiss-Prot:O31586" /translation="MEVNKESLVADELHRMFLAGELQITVEEDINNISERLRNGDLSL DRLSGEDVFIKETVNEALRRVEQ*" /label="ygzA CDS" gene 856453..856656 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /label="ygzA gene" downshifts 856639 /Source="Nicolas_upshifts" /id="D446" /incds=0 /nref=22 /ntot=97 /MaxReadThrough="1.47004" /MaxDrop="5.47861" /score="15.4081475" /energy="-18.2" /TU="NA" /idTUdmin="U676" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(856715) /Source="Nicolas_upshifts" /id="D447" /incds=0 /nref=10 /ntot=35 /MaxReadThrough="1.31339" /MaxDrop="4.8918" /score="26.0684119" /energy="-18.2" /TU="NA" /idTUdmin="U681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(856741..857013) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="YP_003097696.1" /db_xref="EnsemblGenomes-Gn:BSU08779" /db_xref="EnsemblGenomes-Tr:CAX52583" /db_xref="GOA:C0H3X8" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="UniProtKB/Swiss-Prot:C0H3X8" /translation="MYRSKKQSQILSYQELLKKQRRWFPIEQSLCPKDILDLLTTIKT SINKYTVATTATENPHIRRALHDQLDTAVYLHDELSDLLLEKGWLG*" /label="ygzC CDS" gene complement(856741..857013) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /label="ygzC gene" promotor_-10 complement(856972..856990) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(856979) /Source="Nicolas_upshifts" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 856994..857001 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-35" promotor_-35 complement(857007..857012) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 857014..857033 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-10" upshifts 857022 /Source="Nicolas_upshifts" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="upshifts" CDS 857055..857747 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase" /protein_id="NP_388758.2" /db_xref="EnsemblGenomes-Gn:BSU08780" /db_xref="EnsemblGenomes-Tr:CAB12706" /db_xref="GOA:P71089" /db_xref="InterPro:IPR005320" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12230" /db_xref="UniProtKB/Swiss-Prot:P71089" /translation="MKQIIAMGGGGFSMEPDNLSLDQYILNQSKREQPRICFLPTASG DSQNYIQRFYHAFQTLDCVPSHLSLFKPPSSDLVSFVMEMDVIYVGGGNTRNLLVLWK EWGLDHILREAWKNGVVVAGISAGAICWFEEGVTDSAGPLTSLKSLGFLQGSFCPHYD GEKDRRPAYHQLISNKFLCSGYAADDGAALHFINDQLFQTVSSRSGAKAYRVMMAEHE IAEIPLPVKYLG*" /label="ygaJ CDS" gene 857055..857747 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /label="ygaJ gene" promotor_-35 857776..857780 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(857779..857798) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(857791) /Source="Nicolas_upshifts" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 857794..857813 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(857813..857820) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA 857817..857924 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswD RNA" gene 857817..857924 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /label="tswD gene" upshifts 857824 /Source="Nicolas_upshifts" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="upshifts" downshifts 857955 /Source="Nicolas_upshifts" /id="D448" /incds=0 /nref=13 /ntot=48 /MaxReadThrough="8.09735" /MaxDrop="5.74046" /score="17.5556194" /energy="-12.4" /TU="U684" /idTUdmin="U682" /TUdmin=152 /isTUend="FALSE" /label="downshifts" CDS 858057..859829 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /EC_number="4.1.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8432721, 9370266, 10382260, 16291685, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8432721, 9370266, 10382260, 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine synthase" /protein_id="NP_388759.2" /db_xref="EnsemblGenomes-Gn:BSU08790" /db_xref="EnsemblGenomes-Tr:CAB12707" /db_xref="GOA:P45740" /db_xref="InterPro:IPR002817" /db_xref="InterPro:IPR025747" /db_xref="SubtiList:BG11246" /db_xref="UniProtKB/Swiss-Prot:P45740" /translation="MQNNSVQQANISIMSSFSGSKKVYVEGSSSDIQVPMREIALSPT TGSFGEEENAPVRVYDTSGPYTDPEVTINIQEGLKPLRQKWITERGDVEEYEGRAIKP EDNGYKKAKPNVSYPGLKRKPLRAKAGQNVTQMHYAKKGIITPEMEFIAIREHVSPEF VRDEVASGRAIIPSNINHPESEPMIIGRNFHVKINANIGNSAVTSSIEEEVEKMTWAI RWGADTMMDLSTGKDIHTTREWIIRNCPVPVGTVPIYQALEKVNGVAEDLTWEIYRDT LIEQAEQGVDYFTIHAGVLLRYVPLTAKRTTGIVSRGGAIMAQWCLAHHQESFLYTHF EEICEIMKMYDIAFSLGDGLRPGSIADANDEAQFAELETLGELTQIAWKHDVQVMIEG PGHVPMHKIKENVDKQMDICKEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAM LCYVTPKEHLGLPNRDDVREGVITYKIAAHAADLAKGHPGAQIRDDALSKARFEFRWR DQFNLSLDPERALEYHDETLPAEGAKTAHFCSMCGPKFCSMRISQDIRDYAKKNDLSE AEAINKGLKEKAKEFVDTGSNLYQ*" /label="thiC CDS" gene 858057..859829 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /label="thiC gene" downshifts 859805 /Source="Nicolas_upshifts" /id="D449" /incds=0 /nref=166 /ntot=257 /MaxReadThrough="5.77069" /MaxDrop="5.3684" /score="25.2366359" /energy="-15.3" /TU="U684" /idTUdmin="U684" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature 859850..860775 /Source="Nicolas_S_feature" /locus_tag="new_957688_958613" /HighExp="HiOs, GM-0.1, GM 45, GM 60, GM-0.2, BMM, MG 90, T-5.40H, MG 15, MG 25" /AntisenseName="ygaK" /AntisenseCor="-9.7288827054566707E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="SigA" /TUlongPSig=1 /label="S308" CDS complement(859867..861222) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /EC_number="1.21.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8972604; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FAD-dependent oxido-reductase" /protein_id="NP_388760.2" /db_xref="EnsemblGenomes-Gn:BSU08800" /db_xref="EnsemblGenomes-Tr:CAB12708" /db_xref="GOA:Q796Y5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12231" /db_xref="UniProtKB/Swiss-Prot:Q796Y5" /translation="MEKTKLTGRIVTRDDPDYNEARTNINLSLERYPDIIVFCQNKQD ALNALKWARENRVPFRIRGGRHSYENFSLLNNGLVIDLSEMKKITVNQDKKLAYIEAG AELGEVYRTLWQYGLTLPAGTIANVGLTGLTLGGGIGLLTRAAGLTCDSLVQLEMIVA DEKEGADLITVSCSNHPDLFWASQGGGGGNFGIVTSMTFKAVPISQVSIFSITWGWDD FEEVYNTWQNWAPYTDDRLTSSIEFWPKEVNRIEALGQFVGPKTELKKLLKPLLKAGS PTSGMVKTTPFIEAVTFFNSPGGNQPQKMKRSGSFIEKPLSERAISTIKHFLEHAPNQ NASVWQQALGGAAGRVAPDQTAFYYRDAIIAQEYLTNWTSPGEKRQNVRWIEGLRTSL SKETMGDYVNWPDIEIRNWPRTYYGENVERLRRVKTTYDPENVFRFEQSIPPLRRSLF F*" /label="ygaK CDS" gene complement(859867..861222) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /label="ygaK gene" promotor_-10 complement(861250..861269) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(861267) /Source="Nicolas_upshifts" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(861283..861292) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 861340..861346 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 861361..861380 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 861389 /Source="Nicolas_upshifts" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="upshifts" CDS 861473..861670 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1479343, 2108127, 8323536, 16321961" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1479343, 2108127, 8323536, 16321961; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (repressor of ScoC)" /protein_id="NP_388761.2" /db_xref="EnsemblGenomes-Gn:BSU08810" /db_xref="EnsemblGenomes-Tr:CAB12709" /db_xref="GOA:P21344" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG10747" /db_xref="UniProtKB/Swiss-Prot:P21344" /translation="MGVKKEKGRKRFRKRKTYGNQILPLELLIEKNKREIINSAELME EIYMKIDEKHTQCVTKYKKTR*" /label="senS CDS" gene 861473..861670 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /label="senS gene" CDS complement(861697..863148) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /EC_number="1.11.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 12486061, 16535198, 22194458, 27935957" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12486061, 16535198, 22194458, 27935957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vegetative catalase 1" /protein_id="NP_388762.2" /db_xref="EnsemblGenomes-Gn:BSU08820" /db_xref="EnsemblGenomes-Tr:CAB12710" /db_xref="GOA:P26901" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG10849" /db_xref="UniProtKB/Swiss-Prot:P26901" /translation="MSSNKLTTSWGAPVGDNQNSMTAGSRGPTLIQDVHLLEKLAHFN RERVPERVVHAKGAGAHGYFEVTNDVTKYTKAAFLSEVGKRTPLFIRFSTVAGELGSA DTVRDPRGFAVKFYTEEGNYDIVGNNTPVFFIRDAIKFPDFIHTQKRDPKTHLKNPTA VWDFWSLSPESLHQVTILMSDRGIPATLRHMHGFGSHTFKWTNAEGEGVWIKYHFKTE QGVKNLDVNTAAKIAGENPDYHTEDLFNAIENGDYPAWKLYVQIMPLEDANTYRFDPF DVTKVWSQKDYPLIEVGRMVLDRNPENYFAEVEQATFSPGTLVPGIDVSPDKMLQGRL FAYHDAHRYRVGANHQALPINRARNKVNNYQRDGQMRFDDNGGGSVYYEPNSFGGPKE SPEDKQAAYPVQGIADSVSYDHYDHYTQAGDLYRLMSEDERTRLVENIVNAMKPVEKE EIKLRQIEHFYKADPEYGKRVAEGLGLPIKKDS*" /label="katA CDS" gene complement(861697..863148) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /label="katA gene" downshifts complement(861707) /Source="Nicolas_upshifts" /id="D450" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="1.32399" /MaxDrop="8.8938" /score="25.1548262" /energy="-8.3" /TU="NA" /idTUdmin="U688" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 863125..863131 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 863146..863165 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 863149 /Source="Nicolas_upshifts" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(863166..863185) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 863171..863500 /Source="Nicolas_S_feature" /locus_tag="new_961009_961338" /HighExp="S8, C30, S7, S6, BT, C90, B36, S4, S5, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.528" /TUlongSig="NA" /TUlongPSig="NA" /label="S309" upshifts complement(863185) /Source="Nicolas_upshifts" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(863199..863206) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(863244..863262) /Source="Nicolas_upshift_promotors" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(863269) /Source="Nicolas_upshifts" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" downshifts 863457 /Source="Nicolas_upshifts" /id="D451" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="5.89897" /MaxDrop="4.66837" /score="39.0049465" /energy="-19.7" /TU="U687" /idTUdmin="U686" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" CDS 863556..864323 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (ATP-bindingprotein)" /protein_id="NP_388763.3" /db_xref="EnsemblGenomes-Gn:BSU08830" /db_xref="EnsemblGenomes-Tr:CAB12711" /db_xref="GOA:P97027" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017875" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12232" /db_xref="UniProtKB/Swiss-Prot:P97027" /translation="MAVTISIKEKAFVQEGRKNTVLENIELSIAPGEFLTLIGPSGCG KSTLLKIIAGLDSEYDGSVEINGRSVTAPGIQQGFIFQEHRLFPWLTVEQNIAADLNL KDPKVKQKVDELIEIVRLKGSEKAYPRELSGGMSQRVAIARALLREPEVLLLDEPFGA LDAFTRKHLQDVLLDIWRKKKTTMILVTHDIDESVYLGNELAILKAKPGKIHKLMPIH LAYPRNRTTPDFQAIRQRVLSEFEKTEDLEYAEGSGI*" /label="ssuB CDS" gene 863556..864323 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /label="ssuB gene" CDS 864341..865339 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type f: factor" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (binding lipoprotein)" /protein_id="NP_388764.1" /db_xref="EnsemblGenomes-Gn:BSU08840" /db_xref="EnsemblGenomes-Tr:CAB12712" /db_xref="GOA:P40400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR010067" /db_xref="InterPro:IPR015168" /db_xref="SubtiList:BG10656" /db_xref="UniProtKB/Swiss-Prot:P40400" /translation="MKKGLIVLVAVIFLLAGCGANGASGDHKQLKEIRIGIQQSLSPL LIAKEKGWFEDAFEKEGIKVKWVEFQSGPPQFEGLAADKLDFSQVGNSPVIAGQAAGI DFKEIGLSQDGLKANGILVNQNSGIQDVKGLKGKKIAVAKGSSGFDFLYKALDQVGLS ANDVTIIQLQPDEAASAFENGSVDAWSIWEPYLSLETMKHGAKILVNGESTDLYSPGF TLVRTKFSEEHPDEVVRFLKVFNKAVVWQKEHLDEAADLYSDIKDLDKKVVENVLKNT EPLNEIISDDIVKAQQETADFQFRTKAIDKKIDVKDVVDNTFIKKALEEHSSGGDQ*" /label="ssuA CDS" gene 864341..865339 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /label="ssuA gene" CDS 865336..866166 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11390694, 15849754, 16513748, 16850406, 16885442, 9782504" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15849754, 16513748, 16850406, 16885442, 9782504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (permease)" /protein_id="NP_388765.1" /db_xref="EnsemblGenomes-Gn:BSU08850" /db_xref="EnsemblGenomes-Tr:CAB12713" /db_xref="GOA:P40401" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10657" /db_xref="UniProtKB/Swiss-Prot:P40401" /translation="MMKAEAAGSLPKTNAEAVRKKPGRKRYGWMKGLLLPAVIIAIWQ VIGGLGVVSATVLPTPVTIVLTFKELILSGELFGHLQISIYRAALGFLLGAGLGLMIG ILAGFSKRTELYLDPSLQMLRTVPHLAVTPLFILWFGFDEVSKILLIALGAFFPVYIN TFNGIRGVDAKLFEVARVLEFKWHQQISKVILPAALPNILLGIRLSLGIAWLGLVVAE LMGSSSGVGYMIMDARQFSQTNKVFAGIIIFAVVGKLTDSFVRLLERKLLKWRNSYEG *" /label="ssuC CDS" gene 865336..866166 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /label="ssuC gene" CDS 866189..867319 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /EC_number="1.14.14.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9782504, 11390694, 16513748, 16885442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMNH2-dependent aliphatic sulfonate monooxygenase" /protein_id="NP_388766.2" /db_xref="EnsemblGenomes-Gn:BSU08860" /db_xref="EnsemblGenomes-Tr:CAB12714" /db_xref="GOA:P40402" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019911" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10658" /db_xref="UniProtKB/Swiss-Prot:P40402" /translation="MEILWFIPTHGDARYLGSESDGRTADHLYFKQVAQAADRLGYTG VLLPTGRSCEDPWLTASALAGETKDLKFLVAVRPGLMQPSLAARMTSTLDRISDGRLL INVVAGGDPYELAGDGLFISHDERYEATDEFLTVWRRLLQGETVSYEGKHIKVENSNL LFPPQQEPHPPIYFGGSSQAGIEAAAKHTDVYLTWGEPPEQVKEKIERVKKQAAKEGR SVRFGIRLHVIARETEQEAWEAAERLISHLDDDTIAKAQAALSRYDSSGQQRMAVLHQ GDRTKLEISPNLWAGIGLVRGGAGTALVGDPQTIADRIAEYQALGIESFIFSGYPHLE EAYYFAELVFPLLPFENDRTRKLQNKRGEAVGNTYFVKEKNA*" /label="ssuD CDS" gene 866189..867319 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /label="ssuD gene" misc_feature 867346..867365 /Source="Nicolas_upshift_promotors" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 867352 /Source="Nicolas_upshifts" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="upshifts" CDS 867423..867959 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur-related oxidoreductase" /protein_id="NP_388767.1" /db_xref="EnsemblGenomes-Gn:BSU08870" /db_xref="EnsemblGenomes-Tr:CAB12715" /db_xref="SubtiList:BG12233" /db_xref="UniProtKB/Swiss-Prot:P97028" /translation="MLSACGHSKQMEIKAADISDLEKNRMDVAASQAFTAEAVNIGEG ISSADMYIEHYQKGKLVERFGPVRADYSEEKTDTIQFVYFENEEGEGKNKHTTIHFGI VDKQGTIAADSSVKRDDSTTQEMTQNISSPEPITFEKPALIGSSIRGTDETMHTSEHK KELIKHQDALLYYVELHH*" /label="ygaN CDS" gene 867423..867959 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /label="ygaN gene" S_feature 867960..868030 /Source="Nicolas_S_feature" /locus_tag="new_965798_965868" /HighExp="B36, BT, B60, Etha, S5, Heat, S2, BMM, S4, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25357200000000002" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S310" promotor_-35 868000..868007 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 868021..868040 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 868032 /Source="Nicolas_upshifts" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="upshifts" CDS 868071..868340 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 17163968, 19648245, 20208344, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="alternative ribosomal protein S14" /protein_id="NP_388768.1" /db_xref="EnsemblGenomes-Gn:BSU08880" /db_xref="EnsemblGenomes-Tr:CAB12716" /db_xref="GOA:O31587" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023036" /db_xref="SubtiList:BG13085" /db_xref="UniProtKB/Swiss-Prot:O31587" /translation="MAKKSKVAKELKRQQLVEQYAGIRRELKEKGDYEALSKLPRDSA PGRLHNRCMVTGRPRAYMRKFKMSRIAFRELAHKGQIPGVKKASW*" /label="rpsNB CDS" gene 868071..868340 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /label="rpsNB gene" promotor_-35 868143..868147 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 868170..868186 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 868186 /Source="Nicolas_upshifts" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 868327 /Source="Nicolas_upshifts" /id="D452" /incds=0 /nref=41 /ntot=70 /MaxReadThrough="3.14088" /MaxDrop="6.23701" /score="18.4402235" /energy="-10.1" /TU="U692" /idTUdmin="U691" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(868358..868831) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388769.1" /db_xref="EnsemblGenomes-Gn:BSU08890" /db_xref="EnsemblGenomes-Tr:CAB12717" /db_xref="GOA:P97029" /db_xref="SubtiList:BG12234" /db_xref="UniProtKB/Swiss-Prot:P97029" /translation="MSMKTKAAFHLVLFGLACWALISYFEASEGIASFFGTKSGGMVF DLNLTPFILFVAASAVYLYLQKKSRPARKQLLLPDEFEEQDEREQMMTAKACRASYIA VYFSLPAAAVLLIFYPLFQSRIPFFPIIIVFIIMIIQHLSYVISFKKNEKNSGAL*" /label="ygaO CDS" gene complement(868358..868831) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /label="ygaO gene" downshifts complement(868394) /Source="Nicolas_upshifts" /id="D453" /incds=0 /nref=105 /ntot=235 /MaxReadThrough="1.59724" /MaxDrop="4.17785" /score="7.33161195" /energy="-10.1" /TU="NA" /idTUdmin="U693" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(868833..869033) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative HTH-type transcriptional regulator" /protein_id="YP_003097697.1" /db_xref="EnsemblGenomes-Gn:BSU08899" /db_xref="EnsemblGenomes-Tr:CAX52584" /db_xref="GOA:C0H3X9" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="UniProtKB/Swiss-Prot:C0H3X9" /translation="MKNKVKELRARFGYSQEKLGETVGVTRQTVAAIEKGDYVPSLLL ALKICKAFSMKMEDVFWLEEEN*" /label="ygzD CDS" gene complement(868833..869033) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /label="ygzD gene" promotor_-10 complement(869062..869081) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(869076) /Source="Nicolas_upshifts" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(869094..869101) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 869157..869162 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 869176..869195 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 869176 /Source="Nicolas_upshifts" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="upshifts" tRNA 869227..869300 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(TCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gly1 tRNA" gene 869227..869300 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /label="trnSL-Gly1 gene" S_feature 869301..869483 /Source="Nicolas_S_feature" /locus_tag="new_967139_967321" /HighExp="G135, G180, Oxctl, G150, Paraq, H2O2, C30, HPh, LPh, LBGexp" /AntisenseName="yhzB" /AntisenseCor="0.42714037049296899" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S311" CDS complement(869391..870014) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388771.1" /db_xref="EnsemblGenomes-Gn:BSU08900" /db_xref="EnsemblGenomes-Tr:CAB12718" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG13086" /db_xref="UniProtKB/Swiss-Prot:O31588" /translation="MNIKLDSVITERAAGLHAAAVIYENIEVGSSPQMLKGRLRLFQE SLFFDYADGGISDESFVKEWQKLFKQLNPSFEGETTPMEDMLVPISKEQFMESKDSAH DTIDFFALKYSLPIMIYDAGKLHEPVRISLGEKENILLFSDENGIFGDFKNSVNHYPV SNETKNMLQIIFFPPSIEKSSAVNLLSSLTKMFEQIHGGTHTVHWLT*" /label="yhzB CDS" gene complement(869391..870014) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /label="yhzB gene" downshifts complement(869406) /Source="Nicolas_upshifts" /id="D454" /incds=0 /nref=25 /ntot=165 /MaxReadThrough="2.50849" /MaxDrop="4.62652" /score="-8.52782087" /energy="-7.9" /TU="NA" /idTUdmin="U695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 869440 /Source="Nicolas_upshifts" /id="D455" /incds=0 /nref=1 /ntot=88 /MaxReadThrough="4.14204" /MaxDrop="2.36986" /score="16.0836885" /energy="-15.5" /TU="U694" /idTUdmin="U692" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature 869485..870096 /Source="Nicolas_S_feature" /locus_tag="new_967323_967934" /HighExp="G180, G135, G150, Paraq, Oxctl, H2O2, LBGstat, Cold, LBGexp, S6" /AntisenseName="yhzB" /AntisenseCor="0.28959466335762701" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S312" promotor_-10 complement(870038..870057) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(870059) /Source="Nicolas_upshifts" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(870071..870078) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 870097..871257 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /EC_number="1.17.99.-" /function="10.3: tRNA and rRNA base modification" /experiment="publication(s) with functional evidences, PMID:8830270, 21502530, 26230193, 27638883, 28128549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830270, 21502530, 26230193, 27638883, 28128549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epoxyqueuosine reductase" /protein_id="NP_388772.2" /db_xref="EnsemblGenomes-Gn:BSU08910" /db_xref="EnsemblGenomes-Tr:CAB12719" /db_xref="GOA:P97030" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR004453" /db_xref="InterPro:IPR013542" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="PDB:5D08" /db_xref="PDB:5D0A" /db_xref="PDB:5D0B" /db_xref="PDB:5T8Y" /db_xref="SubtiList:BG12236" /db_xref="UniProtKB/Swiss-Prot:P97030" /translation="MNVYQLKEELIEYAKSIGVDKIGFTTADTFDSLKDRLILQESLG YLSGFEEPDIEKRVTPKLLLPKAKSIVAIALAYPSRMKDAPRSTRTERRGIFCRASWG KDYHDVLREKLDLLEDFLKSKHEDIRTKSMVDTGELSDRAVAERAGIGFSAKNCMITT PEYGSYVYLAEMITNIPFEPDVPIEDMCGSCTKCLDACPTGALVNPGQLNAQRCISFL TQTKGFLPDEFRTKIGNRLYGCDTCQTVCPLNKGKDFHLHPEMEPDPEIAKPLLKPLL AISNREFKEKFGHVSGSWRGKKPIQRNAILALAHFKDASALPELTELMHKDPRPVIRG TAAWAIGKIGDPAYAEELEKALEKEKDEEAKLEIEKGIELLKASGMTKQGLS*" /label="queG CDS" gene 870097..871257 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /label="queG gene" downshifts 871266 /Source="Nicolas_upshifts" /id="D456" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="5.29174" /MaxDrop="3.3561" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 871283..871295 /Source="Nicolas_upshift_promotors" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 871288 /Source="Nicolas_upshifts" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="upshifts" CDS 871324..872259 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388773.1" /db_xref="EnsemblGenomes-Gn:BSU08920" /db_xref="EnsemblGenomes-Tr:CAB12720" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG11811" /db_xref="UniProtKB/Swiss-Prot:O31589" /translation="MAGGVSLKYILEQLAEERLGFLVNGHAMRQESQVGDLKVMERKK KLLEKRKVDIIKAKAKAVINHVRVEDDGTTCLSYTIHYEYVCKEQDDSLYIEEHIEER MAFLYDHILISDQEIAKKPAGFHEGTSIIDYSEAEEEREAFGRAFQYDRLGAVQYAEK FWNKRNPAYKNFSDNCTNFISQCLHAGGAPMRGHPNRGSGWWMKQSSWSYSWTVAHSM KMYLSNSKAGLRAVRVKSAEELMPGDVICYDFEGDGRFNHTTIVVAKDKGNMPLVNAQ TYDSRMRYWSYEDSTAYTPSIRYAFFHIVDDTTKE*" /label="yhbB CDS" gene 871324..872259 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /label="yhbB gene" downshifts complement(871342) /Source="Nicolas_upshifts" /id="D457" /incds=0 /nref=2 /ntot=17 /MaxReadThrough="2.06584" /MaxDrop="3.33944" /score="-3.35852865" /energy="-6" /TU="NA" /idTUdmin="U695" /TUdmin="-1936" /isTUend="FALSE" /label="downshifts" promotor_-35 872243..872246 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 872261 /Source="Nicolas_upshifts" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 872262..872281 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 872297..872779 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /EC_number="2.1.1.207" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 20855540; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (cytidine(34)-2'-O)-methyltransferase" /protein_id="NP_388774.2" /db_xref="EnsemblGenomes-Gn:BSU08930" /db_xref="EnsemblGenomes-Tr:CAB12721" /db_xref="GOA:O31590" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR016914" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG11802" /db_xref="UniProtKB/Swiss-Prot:O31590" /translation="MNIVALHVVLYQPEIPANTGNIARTCAATNTTLHLIRPLGFSTD DKMLKRAGLDYWEFVNVVYHDSLEELFEAYKKGKFFFITKFGQQPHTSFDYTDLDEDY FFVFGRETSGLPKDLIQNNMDRCLRLPMTEHVRSLNLSNTAAILVYEALRQQNYRDLK *" /label="trmL CDS" gene 872297..872779 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /label="trmL gene" downshifts 872762 /Source="Nicolas_upshifts" /id="D458" /incds=0 /nref=203 /ntot=259 /MaxReadThrough="4.6846" /MaxDrop="7.03587" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U696" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 872829..873545 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="NP_388775.1" /db_xref="EnsemblGenomes-Gn:BSU08940" /db_xref="EnsemblGenomes-Tr:CAB12722" /db_xref="InterPro:IPR025063" /db_xref="SubtiList:BG12237" /db_xref="UniProtKB/Swiss-Prot:P97032" /translation="MLCFVFGLNNVTVLCYNVPIKGAGLMEEQLISKKELLERTSISY GQLYRWKRKNLIPEEWFIRKSTFTGQETFFPREEILKRISMIQKMKENLSLDEMREML SPKMKDVSMTADELLHKGLVSRPALEAYSEDGGSPVFSSSDLLSLFVLEGLLQSGNVS LAEAKMAAEVLKKHDTEEIEKQTELIVLRKLGVTTCFIAAAADSILFESSVKVVERVD LLKASEELKTTFMQEGHQWM*" /label="yhbD CDS" gene 872829..873545 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /label="yhbD gene" promotor_-35 872849..872856 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 872871..872890 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 872872 /Source="Nicolas_upshifts" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="upshifts" CDS 873536..874249 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388776.1" /db_xref="EnsemblGenomes-Gn:BSU08950" /db_xref="EnsemblGenomes-Tr:CAB12723" /db_xref="InterPro:IPR007607" /db_xref="SubtiList:BG10802" /db_xref="UniProtKB/Swiss-Prot:P39132" /translation="MDVVEKLVINGSGSSKGGTFQSVEINGSGTVAGDVECDTFSFNG NGKADGSVKAKAVTISGSGKIHGDVEAESIRMNGTGFIQGEVSAKQLKIAGSSTFGGT VKADGIDISGKAVMEADCETETFQSEGKCKISGLLNADQVIIKLSAGESYAREIGCRH LQVTCRKGMLTLLRLMPQPVLTAELIEGDVIELTNTKAKTVRGNKVIIGPDCQIETVE YSGDYTCDPSASVETSTKL*" /label="yhbE CDS" gene 873536..874249 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /label="yhbE gene" CDS 874261..874968 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388777.2" /db_xref="EnsemblGenomes-Gn:BSU08960" /db_xref="EnsemblGenomes-Tr:CAB12724" /db_xref="SubtiList:BG10803" /db_xref="UniProtKB/Swiss-Prot:P39133" /translation="METTKLGNLKLYGAGHAAGGAYHNVSIKGEGIVGEGLSAVGCRI YGTGLFLGKAETERLRVLGESECKGDLTAGKINIYGTMKVSGSLQFDRFNLKGQTEIG GNMTGESCDVKGKLSVIGDCETEMFHVTGCVDVSGLLNSGEIKLGLSHDISHVQEIGG TTITVKRRASFFSRKKGKLIADVIEGDRVYLENTEAAVVRGKEVIIGPGCSIGTIEYE YKCECDPHSQIKEKTKL*" /label="yhbF CDS" gene 874261..874968 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /label="yhbF gene" downshifts 874852 /Source="Nicolas_upshifts" /id="D459" /incds=1 /nref=1 /ntot=127 /MaxReadThrough="4.34704" /MaxDrop="2.64409" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 874896 /Source="Nicolas_upshifts" /id="D460" /incds=1 /nref=2 /ntot=35 /MaxReadThrough="4.02504" /MaxDrop="3.21894" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 874962 /Source="Nicolas_upshifts" /id="D461" /incds=0 /nref=2 /ntot=41 /MaxReadThrough="1.06365" /MaxDrop="3.74046" /score="45.497414" /energy="-15.3" /TU="NA" /idTUdmin="U698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(874995..875170) /Source="Nicolas_S_feature" /locus_tag="new_972833_973008_c" /HighExp="M9-stat, BC, S4, T0.30H, LoTm, Lbstat, S2, BT, HiOs, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99846699999999999" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S313" downshifts complement(875038) /Source="Nicolas_upshifts" /id="D462" /incds=0 /nref=63 /ntot=220 /MaxReadThrough="3.38525" /MaxDrop="4.33005" /score="18.2489321" /energy="-13.5" /TU="U699" /idTUdmin="U699" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(875162..875181) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(875170) /Source="Nicolas_upshifts" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(875196..875203) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 875235..875240 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 875256..875274 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 875256 /Source="Nicolas_upshifts" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 875318..877213 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8626065, 12662922, 25983726, 27806131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8626065, 12662922, 25983726, 27806131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine protein kinase (involved in sporulation)" /protein_id="NP_388778.1" /db_xref="EnsemblGenomes-Gn:BSU08970" /db_xref="EnsemblGenomes-Tr:CAB12725" /db_xref="GOA:P39134" /db_xref="InterPro:IPR010650" /db_xref="InterPro:IPR013153" /db_xref="InterPro:IPR016230" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10804" /db_xref="UniProtKB/Swiss-Prot:P39134" /translation="MDILKKIEKYREEEQRLKWEGTFADYLEIIKENPMVAQSAHSRV FNMIKDSGIEEIDGRKKYSFFDRELFGLEESLERLVEEYFHPAAKRLDVRKRILLLMG PVSGGKSTLVTMLKKGLEAYTLTDNGAVYAIKGCPMHEDPLHLIPHHLRDDFYREYGI RIEGSLSPLNVMRLEEEYGGRIEDVKVERIFFSEDKRTGIGTFSPSDPKSQDIADLTG SIDFSTIAEYGSESDPRAYRFDGELNKANRGMMEFQEMLKCDEKFLWHLLSLTQEGNF KAGRFALISADELIVAHTNETEYRSFISNKKNEALHSRIIVMPVPYNLKVSEEERIYE KMIAESDVADVHIAPHTLKVAAMFSILTRLKEPKRSDIDLVKKMRLYDGESVEGYNSV DVEDMKKEYNDEGMSGIDPRYVINRISSTIIRKNMESINSLDVLRSLKEGLDQHPSIS SEDRERYLNFISAARKEYDDIAKKEVQKAFVYSYEESAKTLMDNYLDNVEAYCNKNKL RDPLTGEEMNPDEKLMRSIEEQIGISENAKKAFREEILIRISAYARKGKRFDYNSHER LREAIQKKLFADLKDVVKITTSTKTPDEQQLKKVNEVVARLIDEHGYNSTSANELLKY VGSLLNR*" /label="prkA CDS" gene 875318..877213 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /label="prkA gene" promotor_no_box 875760..875860 /Source="Nicolas_upshift_promotors" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 875820 /Source="Nicolas_upshifts" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 875886 /Source="Nicolas_upshifts" /id="D463" /incds=1 /nref=5 /ntot=18 /MaxReadThrough="7.33384" /MaxDrop="5.65132" /score="45.497414" /energy="-15.3" /TU="U700" /idTUdmin="U701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 877206 /Source="Nicolas_upshifts" /id="D464" /incds=0 /nref=11 /ntot=57 /MaxReadThrough="6.19375" /MaxDrop="4.381" /score="-0.497429548" /energy="-10.6" /TU="U700" /idTUdmin="U703" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 877270..877275 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 877291..877309 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 877294..877392 /Source="Nicolas_S_feature" /locus_tag="new_975132_975230" /HighExp="S6, S7, S5, S8, S4, S3, BT, LoTm, B36, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.971, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S314" upshifts 877294 /Source="Nicolas_upshifts" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 877393..878571 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11988534, 12662922, 14523133, 25983726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 12662922, 14523133, 25983726; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination" /protein_id="NP_388779.1" /db_xref="EnsemblGenomes-Gn:BSU08980" /db_xref="EnsemblGenomes-Tr:CAB12726" /db_xref="InterPro:IPR006698" /db_xref="InterPro:IPR014230" /db_xref="SubtiList:BG11238" /db_xref="UniProtKB/Swiss-Prot:P45742" /translation="MSQNDSGHFLISEENWSLHRKGFDDQQRHQKKVQEAIKNNLPDL VTEESIIMSNGKDVVKIPIRSLDEYKIRYNYDKNKHVGQGDGESQVGDVVARDGSDKK QGPGKGQGAGDQAGEDYYEAEVSLMDLEEALFKELELPNLQQKERDNIIHTDIEFNDI RKTGLTGNIDKKRTMMSAFKRNAMSGKPSFYPIYPEDLKYKTWNDITKPESKAVVLAM MDTSGSMGVWEKYMARSFFFWMTRFLRTKYETVEIEFIAHHTEARVVSEEDFFSKGES GGTICSSVYRKSLELIDEKYNPARYNIYPFHFSDGDNLTSDNARCVKLVNDIMKKANL FCYGEVNQYNRHSTLMSAYKNVKDEKFKYYILKQKSDVFQALKNFFRNEESGVSHQFS *" /label="yhbH CDS" gene 877393..878571 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /label="yhbH gene" promotor_-35 877591..877594 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 877609..877628 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 877613 /Source="Nicolas_upshifts" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(877854) /Source="Nicolas_upshifts" /id="D465" /incds=1 /nref=1 /ntot=23 /MaxReadThrough="2.79078" /MaxDrop="2.94521" /score="-7.1109433" /energy="-11.2" /TU="NA" /idTUdmin="U699" /TUdmin="-3014" /isTUend="FALSE" /label="downshifts" downshifts 878550 /Source="Nicolas_upshifts" /id="D466" /incds=0 /nref=63 /ntot=180 /MaxReadThrough="1.86673" /MaxDrop="8.19565" /score="27.3980811" /energy="-5.6" /TU="NA" /idTUdmin="U702" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 878658..878665 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 878680..878699 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 878680 /Source="Nicolas_upshifts" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 878731..879195 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)induced by acid stress" /protein_id="NP_388780.1" /db_xref="EnsemblGenomes-Gn:BSU08990" /db_xref="EnsemblGenomes-Tr:CAB12727" /db_xref="GOA:O31592" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13003" /db_xref="UniProtKB/Swiss-Prot:O31592" /translation="MTESERALLTFEQLFDTSRAIYKKQKKILEIVLEPFDITVLQYL LMFKIHQSGSTPLSKLAMSLDLKPASVTRMTDILYKRQLMNRYDSPDDRRIVMIQLTE EGEELIEKAAVQYAKMGAGLYQKLDTSQLQYLRKLAGSLTKLAEGCSEKSGN*" /label="yhbI CDS" gene 878731..879195 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /label="yhbI gene" promotor_-35 879020..879026 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 879041..879059 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 879054 /Source="Nicolas_upshifts" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 879204..879210 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 879224..879235 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 879230 /Source="Nicolas_upshifts" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 879231..879896 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane fusion protein; putative exporter subunit (benzoate transcriptome)" /protein_id="NP_388781.1" /db_xref="EnsemblGenomes-Gn:BSU09000" /db_xref="EnsemblGenomes-Tr:CAB12728" /db_xref="GOA:O31593" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG13004" /db_xref="UniProtKB/Swiss-Prot:O31593" /translation="MIEDETKGENKMNRGRLILTNIIGLIVVLAIIAGGAYYYYQSTN YVKTDEAKVAGDMAAITAPAAGKVSDWDLDEGKTVKKGDTVAKIKGEQTVDVKSIMDG TIVKNEVKNGQTVQAGTTIAQTIDMDNLYITANIKETDIADIEVGNSVDVVVDGDPDT TFDGTVEEIGYATNSTFDMLPSTNSSGNYTKVTQKVPVKISIKNPSDKVLPGMNASVK ISE*" /label="yhbJ CDS" gene 879231..879896 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /label="yhbJ gene" CDS 879937..881535 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter (benzoate transcriptome)" /protein_id="NP_388782.1" /db_xref="EnsemblGenomes-Gn:BSU09010" /db_xref="EnsemblGenomes-Tr:CAB12729" /db_xref="GOA:P54585" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11579" /db_xref="UniProtKB/Swiss-Prot:P54585" /translation="MATGKEKNAKNPMSLLIVLMAGLFLAILNQTLLNVAMPHLMTEF GVSATTIQWLTTGYMLVNGVLIPLSAFLITRFGQRSLFLVAMFCFTLGTLVCGIAPNF STMLIGRLIQAVGGGILQPLVMTTILLIFPPESRGKGMGIFGLAMMFAPAVGPTLSGW IIEHYTWRIMFYGLVPIGAIVIIVAFFIFKNMVEPQKIKLDTLGAILSIVGFASLLYG VSEAGSDGWTDPIVLSTVIIGAIAIVAFVVQQLRHDDPMLDFRVFKYDIFSLSSVINI IITVALYTGMFLLPIYLQNLVGFTALQSGLLLLPGAIVMLIMSPISGILFDKFGPRPL AIIGLLVTVVTTYQYTQLTIDTPYTHIMLIYSIRAFGMSLLMMPVMTAGMNQLPARLN SHGTAMSNTLRQISGSIGTSLITTIYTNRTTFHYSQIADKTSTADPNFLHAFQNAVSN LMVNMNVSYDTAKTYVYSHIYKHASLDSNVMGINDAFMWATLFCVAGLILSIFLRDVR KDKLRKKKKEELSLLPAPKEAKES*" /label="yhcA CDS" gene 879937..881535 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /label="yhcA gene" CDS 881558..882088 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /EC_number="1.6.5.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15754243, 18041955, 17951395, 19665595, 20011599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:quinone oxidoreductase associated to benzoate stress" /protein_id="NP_388783.1" /db_xref="EnsemblGenomes-Gn:BSU09020" /db_xref="EnsemblGenomes-Tr:CAB12730" /db_xref="GOA:P54586" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11580" /db_xref="UniProtKB/Swiss-Prot:P54586" /translation="MKIYVVYDSEGEHTKVLAEAIAEGARENDAAEVFIDHVDQADIR KLKDMDAIIWGCPGHFGTISSGLKTWIDRLGYLWAEGELINKVGAVFCTTATTHGGLE MTMHNLITPMFHQGMIVVGLPGNVPENALYGSYYGAGVTCPVDSDELMSEEGIQLGRA LGRRVSQVTGNLTAGQ*" /label="yhcB CDS" gene 881558..882088 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /label="yhcB gene" CDS 882101..882475 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical membrane protein" /protein_id="NP_388784.1" /db_xref="EnsemblGenomes-Gn:BSU09030" /db_xref="EnsemblGenomes-Tr:CAB12731" /db_xref="GOA:P54587" /db_xref="SubtiList:BG11581" /db_xref="UniProtKB/Swiss-Prot:P54587" /translation="MAIIIAIIAAVIVIAALITFNVRNASPGPEKQEATDRIAPPEEE KNEAHYPAEARAAEHTPSVVKNDSPKEKRDTMGDDIYRQALQKFKHSDEVHAEEEVTE ESDKMQDRSYRDALLSMKNKKK*" /label="yhcC CDS" gene 882101..882475 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /label="yhcC gene" downshifts 882464 /Source="Nicolas_upshifts" /id="D467" /incds=0 /nref=32 /ntot=145 /MaxReadThrough="1.78742" /MaxDrop="5.9171" /score="13.777309" /energy="-14.4" /TU="NA" /idTUdmin="U704" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 882475..882630 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388785.1" /db_xref="EnsemblGenomes-Gn:BSU09040" /db_xref="EnsemblGenomes-Tr:CAB12732" /db_xref="SubtiList:BG11582" /db_xref="UniProtKB/Swiss-Prot:P54588" /translation="MKKANPFTHAGLPFLLFPSIMFLSNKSMEYVVFHLDLVYYVTHT PRIFSGR*" /label="yhcD CDS" gene 882475..882630 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /label="yhcD gene" promotor_-35 882565..882571 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 882586..882605 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 882596 /Source="Nicolas_upshifts" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="upshifts" CDS 882635..883396 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane orphan protein" /protein_id="NP_388786.1" /db_xref="EnsemblGenomes-Gn:BSU09050" /db_xref="EnsemblGenomes-Tr:CAB12733" /db_xref="GOA:P54589" /db_xref="SubtiList:BG11583" /db_xref="UniProtKB/Swiss-Prot:P54589" /translation="MNSFLGLLKKDIKLSRMWLLVWICGIIFLLGTGHIIASRTKEPL VIFGFFVAVAFFLLFLSPVFVFYHLRKEGKSQLWLYNPNGGLWLFSSKLAASLLYQFV IQLALTAYGIWMYHMLSVKNLLEHQVDITSTVALLNMYGLISSLDMSVTVIVFWTVFH SLRNWRGMRWAAMVLLVAMWLFFDEYIISPLVESQKHFWPVTVYCNFDFHFHNVWRLE LKPIHLSVLGFPIAIVITFLLLIMASKLLDRKVEV*" /label="yhcE CDS" gene 882635..883396 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /label="yhcE gene" promotor_-10 complement(882948..882966) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(882962) /Source="Nicolas_upshifts" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(882982..882987) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 883399..883764 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388787.1" /db_xref="EnsemblGenomes-Gn:BSU09060" /db_xref="EnsemblGenomes-Tr:CAB12734" /db_xref="GOA:P54590" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11584" /db_xref="UniProtKB/Swiss-Prot:P54590" /translation="MDNQFQSSKPIYLQIADQIFYRLVRKELLPGDKLPSVREMAIQT KVNPNTIQRTYSEMERLGIVETRRGQGTFIAEKAEIVDELKDKLTREVLEGFVKQMKE LGLTKEEMLEGIKTFTEGG*" /label="yhcF CDS" gene 883399..883764 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /label="yhcF gene" CDS 883766..884464 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter ATP-binding protein" /protein_id="NP_388788.1" /db_xref="EnsemblGenomes-Gn:BSU09070" /db_xref="EnsemblGenomes-Tr:CAB12735" /db_xref="GOA:P54591" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11585" /db_xref="UniProtKB/Swiss-Prot:P54591" /translation="MEIKLEHVSKKYGRHTAVNDVSITLSSGRIYGLIGPNGSGKSTT LKMMAGLLFPTSGFVKVDEEQVTREMVRQTAYLTELDMFYPHFTVKDMVNFYQSQFPD FHTEQVYKLLNEMQLNPEKKIKKLSKGNRGRLKIVLALARRADVILLDEPFSGLDPMV RDSIVNSLVSYIDFEQQIVVIATHEIDEIETLLDEVIILANGEKVAQREVEDIREQEG MSVLQWFKSKMEVC*" /label="yhcG CDS" gene 883766..884464 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /label="yhcG gene" CDS 884481..885398 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7476193, 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388789.1" /db_xref="EnsemblGenomes-Gn:BSU09080" /db_xref="EnsemblGenomes-Tr:CAB12736" /db_xref="GOA:P54592" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11586" /db_xref="UniProtKB/Swiss-Prot:P54592" /translation="MKTVLELKNVTKNIRGRTIIDDLSFTIREGEVFGFLGPNGAGKT TTIRMMVGLMKLSKGDVLICGQSITKEYAKAIKHIGAIVENPELYKFLSGYKNLQQFA RMVKGVTKEKIDEVVELVGLTDRIHDKVKTYSLGMRQRLGLAQCLLHDPKVLILDEPT NGLDPAGIREIRDHLKKLTRERGMAVIVSSHLLSEMELMCDRIAILQKGKLIDIQNVK DENIDENDTYFFQVEQPSEAATVLNQYDLLSKTNGVEIKLAKEEVPAVIELLVMQQIR IYEVKVITKSLEDRFLEMTGETKEEVQHA*" /label="yhcH CDS" gene 884481..885398 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /label="yhcH gene" CDS 885391..886332 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15870467, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_388790.1" /db_xref="EnsemblGenomes-Gn:BSU09090" /db_xref="EnsemblGenomes-Tr:CAB12737" /db_xref="GOA:P54593" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11587" /db_xref="UniProtKB/Swiss-Prot:P54593" /translation="MLNLIYNEWLKIFSRAGTWVMIGILGLTMVGFAFLANHFSAGES NSHWKQELQAQNAELKKEIKEDPSLKDGYKETITLNDYRIEHNIPSDTGYTVWSYVTD SANFTILTGLFTIIIAAGIVANEFNWGTIKLLMIRPLSRFQILMSKYITVLLFGLLLL LILFIGSTLLGLIFFGTGGETAANIHLIYKDGHVIEQNMMGHLATTYLSESVSALMVA TMAFMLSAVFRNSSLAVGFSIFLLVAGTTATAFIAAKFDWAKYILFANVDLTQYVDGT PLIKGMTMTFSLVMLAIYFIIFLLLAFGIFMKRDIAN*" /label="yhcI CDS" gene 885391..886332 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /label="yhcI gene" downshifts 886314 /Source="Nicolas_upshifts" /id="D468" /incds=0 /nref=43 /ntot=186 /MaxReadThrough="2.67567" /MaxDrop="4.46232" /score="20.0218504" /energy="-13.6" /TU="NA" /idTUdmin="U707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(886424..886627) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12493834, 16352840, 22128343, 25851716" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12493834, 16352840, 22128343, 25851716; Product type f: factor" /codon_start=1 /transl_table=11 /product="major cold-shock protein, RNA helicase co-factor, RNA co-chaperone" /protein_id="NP_388791.1" /db_xref="EnsemblGenomes-Gn:BSU09100" /db_xref="EnsemblGenomes-Tr:CAB12738" /db_xref="GOA:P32081" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="PDB:1CSP" /db_xref="PDB:1CSQ" /db_xref="PDB:1NMF" /db_xref="PDB:1NMG" /db_xref="PDB:2ES2" /db_xref="PDB:2F52" /db_xref="PDB:2I5L" /db_xref="PDB:2I5M" /db_xref="PDB:3PF4" /db_xref="PDB:3PF5" /db_xref="SubtiList:BG10824" /db_xref="UniProtKB/Swiss-Prot:P32081" /translation="MLEGKVKWFNSEKGFGFIEVEGQDDVFVHFSAIQGEGFKTLEEG QAVSFEIVEGNRGPQAANVTKEA*" /label="cspB CDS" gene complement(886424..886627) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /label="cspB gene" downshifts complement(886438) /Source="Nicolas_upshifts" /id="D469" /incds=0 /nref=169 /ntot=281 /MaxReadThrough="5.28215" /MaxDrop="9.14889" /score="33.2405587" /energy="-13.1" /TU="U710" /idTUdmin="U710" /TUdmin="-48" /isTUend="FALSE" /label="downshifts" S_feature complement(886628..886755) /Source="Nicolas_S_feature" /locus_tag="new_984466_984593_c" /HighExp="BC, C90, GM 15, BI, T-1.10H, UNK1, S1, Sw, nit, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S315" misc_feature 886715..886726 /Source="Nicolas_upshift_promotors" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 886732 /Source="Nicolas_upshifts" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(886744..886763) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(886755) /Source="Nicolas_upshifts" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(886757..887895) /Source="Nicolas_S_feature" /locus_tag="new_984595_985733_c" /HighExp="C30, G180, G150, Oxctl, G135, Paraq, HPh, LPh, dia0, Lbexp" /AntisenseName="yhcJ" /AntisenseCor="0.25433958616302499" /AntisenseRegPval="-4.5999999999999996" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S316" promotor_-35 complement(886777..886782) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 886922..886929 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 886944..886962 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 886951 /Source="Nicolas_upshifts" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 886952..887062 /Source="Nicolas_S_feature" /locus_tag="new_984790_984900" /HighExp="Diami, dia15, dia5, H2O2, Salt, C90, Paraq, UNK1, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S317" CDS 887063..887893 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_388792.2" /db_xref="EnsemblGenomes-Gn:BSU09110" /db_xref="EnsemblGenomes-Tr:CAB12739" /db_xref="GOA:P54594" /db_xref="InterPro:IPR004872" /db_xref="SubtiList:BG11588" /db_xref="UniProtKB/Swiss-Prot:P54594" /translation="MKKWLICSFVLVLLVSFTACSPSAEHESIKIGIAESDGAIWNYI AQKAEEAGLDIQLIPFSDYAESDIALANKEIDANAFQTISYFQSFTEKYKLNLAPLGT TYITPMGIYSKRYERIRDISRGAVVSVPDKAFDFGRALTVLQEAGLLTLKNGFNGTGS VDMIKDNPRHLKLKAVRQQDAVSGADVFVMKPSEAKKAGLNPKKHTLKSGGLMSEEEM NLIVVRAEDQDREALQTILELYQADDTAAFIEKEYQGDLVPAFLPLKRLSDWKNEFEH *" /label="yhcJ CDS" gene 887063..887893 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /label="yhcJ gene" downshifts 887852 /Source="Nicolas_upshifts" /id="D470" /incds=0 /nref=38 /ntot=203 /MaxReadThrough="2.83059" /MaxDrop="3.90173" /score="-4.94928928" /energy="-7.3" /TU="NA" /idTUdmin="U711" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(887896..888975) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_388793.1" /db_xref="EnsemblGenomes-Gn:BSU09120" /db_xref="EnsemblGenomes-Tr:CAB12740" /db_xref="GOA:P54595" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG11589" /db_xref="UniProtKB/Swiss-Prot:P54595" /translation="MLKELFVNLTILITFNYLFTHLFKERLVHKKDSISFQAVKGLAC GLLGVILMVFGFTYQHSIIDLRNIPIMIAALYGGWVSTATALAMITAGRLLITMNTSA LYSVIIICIAAIPSLIVSRRKKVQLKHAFYLLIITNSLISFSFYFLIDLHSYELHLYF WIISIAGGMLSLYIIDHETNAHLLFKQYKFQAHFDFLTGVYNRRKFEETTKALYQQAA DTPHFQFALIYMDIDHFKTINDQYGHHEGDQVLKELGLRLKQTIRNTDPAARIGGEEF AVLLPNCSLDKAARIAERIRSTVSDAPIVLTNGDELSVTISLGAAHYPNNTEQPGSLP ILADQMLYKAKETGRNRVCFSEKKE*" /label="dgcK CDS" gene complement(887896..888975) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /label="dgcK gene" promotor_-10 complement(888985..889004) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-10" upshifts complement(889006) /Source="Nicolas_upshifts" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="upshifts" promotor_-35 complement(889020..889024) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-35" promotor_-35 889082..889089 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 889103..889122 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 889109 /Source="Nicolas_upshifts" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="upshifts" CDS 889148..890539 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12193636, 15262924, 15849754, 16513748, 16850406, 19508281" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 15262924, 15849754, 16513748, 16850406, 19508281; Product type t : transporter" /codon_start=1 /transl_table=11 /product="(sodium)-cystine symporter" /protein_id="NP_388794.1" /db_xref="EnsemblGenomes-Gn:BSU09130" /db_xref="EnsemblGenomes-Tr:CAB12741" /db_xref="GOA:P54596" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11590" /db_xref="UniProtKB/Swiss-Prot:P54596" /translation="METLLVVLHVFILFLLILGLFVMQKKHVSFSKRVFTALGLGIVF GFALQLIYGPTSNIVIQTADWFNIAGGGYVKLLQMVVMPLVFISILGAFTKLKLTKNL GKISGLIIGILVATTAVAAAVGIASALSFDLQAIQVDQGSTELSRGQELQQKSEDMTA KTLPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGVAFLGVKHKQPEQAETFKKL VDAVYAIVMRVVTLILRLTPYGVLAIMTKTIATSDLDSILKLGMFVIASYAALITMFI IHLLLLTFSGLNPVIYLKKAVPVLVFAFTSRSSAGALPLNIKTQRSMGVPEGIANFAG SFGLSIGQNGCAGIYPAMLAMMIAPTVGQNPFDPVFIITVIAVVAISSFGVAGVGGGA TFAALLVLSSLNMPVALAGLLISIEPLIDMGRTALNVSGSMTSGLITSKVTKEIDQGA FHDQSRVIEAEEA*" /label="tcyP CDS" gene 889148..890539 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /label="tcyP gene" S_feature complement(890175..890578) /Source="Nicolas_S_feature" /locus_tag="new_988013_988416_c" /HighExp="S8, S6, Etha, S5, S7, S4, ferm, nit, Salt, S3" /AntisenseName="tcyP" /AntisenseCor="-0.40132140065468203" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S318" downshifts 890518 /Source="Nicolas_upshifts" /id="D471" /incds=0 /nref=58 /ntot=164 /MaxReadThrough="2.37899" /MaxDrop="5.34563" /score="19.9118074" /energy="-12.8" /TU="NA" /idTUdmin="U713" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(890579..891034) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21625606" /codon_start=1 /transl_table=11 /product="expressed protein of unknown function" /protein_id="NP_388795.1" /db_xref="EnsemblGenomes-Gn:BSU09140" /db_xref="EnsemblGenomes-Tr:CAB12742" /db_xref="SubtiList:BG11591" /db_xref="UniProtKB/Swiss-Prot:P54597" /translation="MLFNQRRGISPAALIIGSTMLITALSPQIRQRISGFITGQMNRR NSENNTFDASNVGNMVKQAFSGSSGSSGDNQDRSQHQSQRQNGRQHQHAGQQQPQHQH TQSQTRQTETAAKKRQPHYAEPIHFEQNAMNVMDDNTMMEMLEDLEPGR*" /label="yhcM CDS" gene complement(890579..891034) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /label="yhcM gene" promotor_-10 complement(891049..891067) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(891077) /Source="Nicolas_upshifts" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(891082..891088) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 891126..891132 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 891146..891157 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 891150 /Source="Nicolas_upshifts" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="upshifts" CDS 891184..891753 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9611260, 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_388796.2" /db_xref="EnsemblGenomes-Gn:BSU09150" /db_xref="EnsemblGenomes-Tr:CAB12743" /db_xref="GOA:P54598" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG11592" /db_xref="UniProtKB/Swiss-Prot:P54598" /translation="MFGKKQVLASVLLIPLLMTGCGVADQGEGRRDNNDVRNVNYRNP ANDDMRNVNNRDNVDNNVNDNVNNNRVNDDNNNDRKLEVADEAADKVTDLKEVKHADI IVAGNQAYVAVVLTNGNKGAVENNLKKKIAKKVRSTDKNIDNVYVSANPDFVERMQGY GKRIQNGDPIAGLFDEFTQTVQRVFPNAE*" /label="yhcN CDS" gene 891184..891753 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /label="yhcN gene" promotor_-35 891380..891386 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 891397 /Source="Nicolas_upshifts" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 891400..891411 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 891728 /Source="Nicolas_upshifts" /id="D472" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="1.84697" /MaxDrop="7.80159" /score="33.0647397" /energy="-12.9" /TU="NA" /idTUdmin="U715" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-35 891796..891805 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 891819..891838 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 891829 /Source="Nicolas_upshifts" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="upshifts" CDS 891874..892842 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein (sporulation germination island)" /protein_id="NP_388797.2" /db_xref="EnsemblGenomes-Gn:BSU09165" /db_xref="EnsemblGenomes-Tr:CAB12744" /db_xref="SubtiList:BG11593" /db_xref="UniProtKB/Swiss-Prot:P54599" /translation="MRDGIGKRAASALFLCGVLVMLAVSSAIVSSAMYILSFPGQASG ITKEQVTKHMKKESFKQADIYYTSKEKSLLPLTKETLEYAVSINQIMIGYSNQKPIDI IFFPNEKQMEAYSGLLDVVGFYSEREQLIGLLPEEKKKLLEGDEVAVYLYQRLLIHEY SHHAFHQKLKELETDPDEFPLWFHEGLSEWIANYELLIDPITFSVVPFDRLQTDRDWQ EARAEYDTDVYLQSFYMIDELTDKYGKDIISEMIKETAKKGDFEKGFKSATKESLDQF EKDFKKKFEKNSAALDSIYPMPLLLVKSLLTHSALCRRHLSLGRGE*" /label="yhcO CDS" gene 891874..892842 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /label="yhcO gene" downshifts 892718 /Source="Nicolas_upshifts" /id="D473" /incds=1 /nref=28 /ntot=62 /MaxReadThrough="1.51621" /MaxDrop="5.75619" /score="6.21571271" /energy="-16.1" /TU="NA" /idTUdmin="U717" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(892774..893427) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_388799.1" /db_xref="EnsemblGenomes-Gn:BSU09180" /db_xref="EnsemblGenomes-Tr:CAB12746" /db_xref="GOA:P54601" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG11595" /db_xref="UniProtKB/Swiss-Prot:P54601" /translation="MDQFNQQQQSQMNKGIPGKPHKNHGGHEMFDMHEVLSGTLTVLD QFMMLRQFCKDQELLNILDRQHQFITSQYNITAECFKTGSEPSQKTATYMMKEDNQTV YGMQPSQPKKPVQSMNDIDDSIISRQMLCAIKAQASMLTMASLEMTNPAVRRVLSAQI QEYVEMAFEIFLYQNKHGYYQVPQLDAQDMEQLRNSFAPAQGQMPPTQGGMGQQGLH* " /label="yhcQ CDS" gene complement(892774..893427) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /label="yhcQ gene" downshifts complement(892791) /Source="Nicolas_upshifts" /id="D474" /incds=0 /nref=15 /ntot=57 /MaxReadThrough="4.13099" /MaxDrop="4.95733" /score="8.67086892" /energy="-12.9" /TU="U718" /idTUdmin="U718" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(893458..893469) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(893460) /Source="Nicolas_upshifts" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(893484..893490) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 893499..893507 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 893510..897163 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15292138, 21800427, 22020651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292138, 21800427, 22020651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non specific extracellular Ca2+-dependent endonuclease cleaving RNA and DNA" /protein_id="NP_388800.1" /db_xref="EnsemblGenomes-Gn:BSU09190" /db_xref="EnsemblGenomes-Tr:CAB12747" /db_xref="GOA:P54602" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR019948" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR035437" /db_xref="InterPro:IPR035451" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG11596" /db_xref="UniProtKB/Swiss-Prot:P54602" /translation="MLSVEMISRQNRCHYVYKGGNMMRRILHIVLITALMFLNVMYTF EAVKAAEPQQPISIEKAIQQKEGQALVEGYAVGQAVSPQHYKLTSPFSNDYNVALADR KNKTSPEHILPVQIPSAFRSQFGLQTNPLLLGKKITVQGKLENYFNTTGLKNVQSMNV TDDTKTPPAEQQVTINEARGRLNEEVTIKGIITADQNAIGGGKLSTFLQDETGGINIY SPSPEQFPELKEGMDVTVTGKITSYQGLKEIVPNSSGIKINQSNQSLPAPKHLTINEL INGSLGDQYEGRLVKLTAFVSSIPSSPAGGGYNVTMIDDDHHAMTLRVMNETGVINEL DEGKWYEFTGVLSRYQTFQLLPRKSADLKLLEEQPAPPSAEGEYEGIVDRVVDGDTIH LKSPVLGTTKIRFVNVDAPETYHTPKNDADENQLRFGKKASDYLKTVLSPGDKITVKV GSEAKDSYGRLLGQVITESGSNVNLELVKNGYAPTYFIWPVDNEEDYQQFQAAVAAAK KDQKGIWNENDPLMEMPFEFRAREQGKGLTRYVGDSSNKTYVQPADWKKIAVENRIFF ASASEAESAGYKKRQTAPQEHVPLRILSMNDLHGKIDQQYELDLDGNGTVDGTFGRMD YAAAYLKEKKAEKKNSLIVHAGDMIGGSSPVSSLLQDEPTVELMEDIGFDVGTVGNHE FDEGTDELLRILNGGDHPKGTSGYDGQNFPLVCANCKMKSTGEPFLPAYDIINVEGVP VAFIGVVTQSAAGMVMPEGIKNIEFTDEATAVNKAAEELKKKGVKAIAVLAHMSAEQN GNAITGESADLANKTDSEIDVIFAAHNHQVVNGEVNGKLIVQAFEYGKAIGVVDVEID KTTKDIVKKSAEIVYVDQSKIEPDVSASAILKKYETIAEPIISEVVGEAAVDMEGGYS NDGDTPLGNLIADGMRAAMKTDFALMNGGGIREALKKGPITWGDLYNIQPFGNVLTKL EIKGKDLREIINAQISPVFGPDYSISGFTYTWDKETGKAVDMKMADGTEIQPDATYTL TVNNFMATATGAKYQPIGLLGKNPVTGPEDLEATVEYVKSFDEPIAYTKEGRIKLAEA SDIEDPVTEDPITEEPGDDPGTEDPIKEDPRPGEDLPDIKETPGTAPVHQLPPSAISR FNEIPINNTKTADTANSISTLPLQTETAESGSDHQLPDTSAGYYNFMVIGAAVTLSGT YLYVRRKRSASRT*" /label="mncR CDS" gene 893510..897163 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /label="mncR gene" promotor_-10 893518..893536 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 893533 /Source="Nicolas_upshifts" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="upshifts" CDS 897160..897756 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /EC_number="3.4.22.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12823805, 21800427, 22020651, 25038633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12823805, 21800427, 22020651, 25038633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sortase A" /protein_id="NP_388801.1" /db_xref="EnsemblGenomes-Gn:BSU09200" /db_xref="EnsemblGenomes-Tr:CAB12748" /db_xref="GOA:P54603" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG11597" /db_xref="UniProtKB/Swiss-Prot:P54603" /translation="MKKVIPLFIIAAGLVIAGYGGFKLIDTNTKTEQTLKEAKLAAKK PQEASGTKNSTDQAKNKASFKPETGQASGILEIPKINAELPIVEGTDADDLEKGVGHY KDSYYPDENGQIVLSGHRDTVFRRTGELEKGDQLRLLLSYGEFTYEIVKTKIVDKDDT SIITLQHEKEELILTTCYPFSYVGNAPKRYIIYGKRVT*" /label="srtA CDS" gene 897160..897756 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /label="srtA gene" downshifts 897735 /Source="Nicolas_upshifts" /id="D475" /incds=0 /nref=142 /ntot=248 /MaxReadThrough="0.9984" /MaxDrop="5.92245" /score="-4.06268332" /energy="-8.8" /TU="NA" /idTUdmin="U719" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(897786..898694) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /EC_number="5.4.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9814761, 15044829; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA pseudouridine synthase" /protein_id="NP_388802.2" /db_xref="EnsemblGenomes-Gn:BSU09210" /db_xref="EnsemblGenomes-Tr:CAB12749" /db_xref="GOA:P54604" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11598" /db_xref="UniProtKB/Swiss-Prot:P54604" /translation="MNQKGRGLEILINEKQDGQWLFSVLKTALKASKPVIQDWMSHQQ IKVNHESVLNNMIVKKGDRVFIDLQESEASSVIPEYGELDILFEDNHMLIINKPAGIA THPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTSGAIVFAKHRLAHAILDQQ LEKKTLKRTYTAIAEGKLRTKKGTINSPIGRDRSHPTRRRVSPGGQTAVTHFKVMASN AKERLSLVELELETGRTHQIRVHLASLGHPLTGDSLYGGGSKLLNRQALHANKVQAVH PITDELIVAEAPFPADMKNLCRTYFS*" /label="yhcT CDS" gene complement(897786..898694) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /label="yhcT gene" promotor_-35 898750..898758 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(898751..898762) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(898757) /Source="Nicolas_upshifts" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(898759..899245) /Source="Nicolas_S_feature" /locus_tag="new_996597_997083_c" /HighExp="S8, dia15, Diami, H2O2, G180, G150, dia5, Paraq, Oxctl, S7" /AntisenseName="yhcU" /AntisenseCor="0.69394173601478304" /AntisenseRegPval="-39.200000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S319" upshifts 898769 /Source="Nicolas_upshifts" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 898772..898791 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(898776..898782) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 898805..899200 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388803.2" /db_xref="EnsemblGenomes-Gn:BSU09220" /db_xref="EnsemblGenomes-Tr:CAB12750" /db_xref="InterPro:IPR020355" /db_xref="SubtiList:BG11599" /db_xref="UniProtKB/Swiss-Prot:P54605" /translation="MARKVIDVRIVNAATAEQESFIKELSMELIHDVFPLYFSELDIQ RFKKKGVLSLNNHYYQGTLKEAFQIMACLQMIHIILTKPSPHSDLSDQAIFEKNSKML NDFGIYFPFAFSDFQKKTNKAFFGQRRLI*" /label="yhcU CDS" gene 898805..899200 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /label="yhcU gene" misc_feature complement(899231..899250) /Source="Nicolas_upshift_promotors" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(899245) /Source="Nicolas_upshifts" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 899285..899291 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 899300 /Source="Nicolas_upshifts" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 899305..899316 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(899315..899329) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(899329) /Source="Nicolas_upshifts" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(899337..899341) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 899337..899759 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CBS containing enzyme (sporulation-/ germination-related)" /protein_id="NP_388804.1" /db_xref="EnsemblGenomes-Gn:BSU09230" /db_xref="EnsemblGenomes-Tr:CAB12751" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG11600" /db_xref="UniProtKB/Swiss-Prot:P54606" /translation="MSSVKDTMTTQVATVSPNQTIQEAASLMKQHNVGAIPVVEQGVL KGMLTDRDIALRTTAQGRDGQTPVSEVMSTELVSGNPNMSLEDASQLMAQHQIRRLPI VDQNNLVGIVALGDLAVNQMSNESAGSALTNISHQNIH*" /label="yhcV CDS" gene 899337..899759 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /label="yhcV gene" promotor_no_box complement(899663..899763) /Source="Nicolas_upshift_promotors" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(899703) /Source="Nicolas_upshifts" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 899737 /Source="Nicolas_upshifts" /id="D476" /incds=0 /nref=50 /ntot=61 /MaxReadThrough="2.62549" /MaxDrop="7.03747" /score="-2.59023198" /energy="-12.1" /TU="NA" /idTUdmin="U723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(899769) /Source="Nicolas_upshifts" /id="D477" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="0.0992700000000006" /MaxDrop="3.96142" /score="-9.32793172" /energy="-9.1" /TU="NA" /idTUdmin="U724" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" promotor_-35 899809..899816 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 899830..899849 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 899838 /Source="Nicolas_upshifts" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="upshifts" CDS 899886..900548 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /EC_number="3.1.3.18" /EC_number="3.1.3.68" /EC_number="3.1.3.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16990279, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphoglycolate phosphatase / glycerol-3-phosphate phosphatase / 2-deoxyglucose-6-phosphatase" /protein_id="NP_388805.1" /db_xref="EnsemblGenomes-Gn:BSU09240" /db_xref="EnsemblGenomes-Tr:CAB12752" /db_xref="GOA:P54607" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11601" /db_xref="UniProtKB/Swiss-Prot:P54607" /translation="MIKALIFDFDGLILDTETHEYEVLQEIFEEHGSVLPLSVWGKVI GTAAGFRPFEYLEEQIGKKLNHEELTQLRRERFAKRMESEKARPGVEAYLNAAKDLGL KIGLASSSDYKWVSGHLKQIGLFDDFEVIQTADDVEEVKPNPELYLLAAKNLGVSPAE CLAFEDSVNGSIAAKRAGMKCVIVPNKVTGTLMFEDYDHRLESMAEMELALLLDHLNS QN*" /label="glpW CDS" gene 899886..900548 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /label="glpW gene" CDS 900564..902105 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /EC_number="3.5.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26337367, 26808445, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388806.2" /db_xref="EnsemblGenomes-Gn:BSU09250" /db_xref="EnsemblGenomes-Tr:CAB12753" /db_xref="GOA:P54608" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR001110" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG11602" /db_xref="UniProtKB/Swiss-Prot:P54608" /translation="MSEKLDLTRFEKKMVIRNIEEKDIDKIIDLQKDCFPGMEPWKRE HLISHLEHFPEGQFCAEFEGEIIGSCSSLLINFDEYDDRHTWQDITDDGYITNHNPDG LNMYGIEVMVHPKYRRMKIGHRLYEARKDLARRLNLKSIIIGGRIPNYHKYAEEMTAR EYVEQVTRHQIYDPVLSFQLMNGFTLMRINPNYLPDDTASIKYATLMEWNNVDYLPQQ TKRYYKSAFPVRICVIQYEMKKIYSFEEFANQVEYYVDVASDARSDFAVFPEIFTTQL MSFLEERSPSLAVQRITEYTEDYISLFTDLAVKYNVNIIGGSHFVEEEGKIYNIAYLF RRDGTIEKQYKLHITPNERKWWGISAGDQVRVFDTDCGKIAIQICYDIEFPELARIAA DKGAKIIFTPFCTEDRQGYLRVRYCSQARAVENQIYTVISGTVGNLPQTENMDIQYAQ SGIFAPSDFEFARDGIVGETNPNIEMVVIGDVDLEILRRQRQNGTVRQLKDRRRDIYH IQYKK*" /label="yhcX CDS" gene 900564..902105 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /label="yhcX gene" downshifts 902088 /Source="Nicolas_upshifts" /id="D478" /incds=0 /nref=57 /ntot=238 /MaxReadThrough="4.24486" /MaxDrop="5.06754" /score="24.7413026" /energy="-10.5" /TU="U726" /idTUdmin="U726" /TUdmin="-224" /isTUend="FALSE" /label="downshifts" CDS 902189..902380 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52585.1" /translation="MYSGCALWSFCIFAISYIIQKTARLHIAIAMAVQVVSSATFIST MLSIVTLPVLLWKLHPLSS*" /label="yhzG CDS" gene 902189..902380 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /pseudo /label="yhzG gene" promotor_-35 902411..902418 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-35" promotor_-10 902433..902452 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-10" S_feature 902444..902525 /Source="Nicolas_S_feature" /locus_tag="new_1000282_1000363" /HighExp="M40t90, M0t90, T0.30H, LBGstat, BC, Lbstat, M9-stat, Lbtran, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S320" upshifts 902444 /Source="Nicolas_upshifts" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="upshifts" CDS 902526..903878 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11082195, 23610425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase" /protein_id="NP_388807.2" /db_xref="EnsemblGenomes-Gn:BSU09260" /db_xref="EnsemblGenomes-Tr:CAB12754" /db_xref="GOA:P33189" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10184" /db_xref="UniProtKB/Swiss-Prot:P33189" /translation="MEMMGMENIQQNQGLKQKDEQFVWHAMKGAHQADSLIAQKAEGA WVTDTDGRRYLDAMSGLWCVNIGYGRKELAEAAYEQLKELPYYPLTQSHAPAIQLAEK LNEWLGGDYVIFFSNSGSEANETAFKIARQYHLQNGDHSRYKFISRYRAYHGNTLGAL SATGQAQRKYKYEPLSQGFLHAAPPDIYRNPDDADTLESANEIDRIMTWELSETIAGV IMEPIITGGGILMPPDGYMKKVEDICRRHGALLICDEVICGFGRTGEPFGFMHYGVKP DIITMAKGITSAYLPLSATAVKRDIFEAYQGEAPYDRFRHVNTFGGSPAACALALKNL QIMEDEQLIQRSRDLGAKLLGELQALREHPAVGDVRGKGLLIGIELVKDKLTKEPADA AKVNQVVAACKEKGLIIGKNGDTVAGYNNVIQLAPPFCLTEEDLSFIVKTVKESFQTI *" /label="yhxA CDS" gene 902526..903878 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /label="yhxA gene" CDS 903906..904484 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11929549, 23610425, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 23610425, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate responding transcriptionantiterminator" /protein_id="NP_388808.1" /db_xref="EnsemblGenomes-Gn:BSU09270" /db_xref="EnsemblGenomes-Tr:CAB12755" /db_xref="GOA:P30300" /db_xref="InterPro:IPR006699" /db_xref="InterPro:IPR035928" /db_xref="SubtiList:BG10185" /db_xref="UniProtKB/Swiss-Prot:P30300" /translation="MMSFHNQPILPAIRNMKQFDEFLNSSFSYGVILDIHLGQLKGVI KEAQKHGKNMMVHVDLIQGIKHDEYGAEFICQDIKPAGIISTRSNVIAKAKQKKIYAI QRLFLLDTSAMEKSMEFIGKHKPDFIEVLPGIVPSLIQEIKEKTGIPIFAGGFIRTEE DVEQALKAGAVAVTTSNTKLWKKYENFLTESD*" /label="glpP CDS" gene 903906..904484 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /label="glpP gene" promotor_-35 904479..904486 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 904501..904520 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 904512 /Source="Nicolas_upshifts" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" downshifts 904527 /Source="Nicolas_upshifts" /id="D479" /incds=0 /nref=3 /ntot=39 /MaxReadThrough="8.20986" /MaxDrop="2.99328" /score="6.07464219" /energy="-10" /TU="U727,U728" /idTUdmin="U726" /TUdmin=2215 /isTUend="FALSE" /label="downshifts" S_feature 904572..904662 /Source="Nicolas_S_feature" /locus_tag="new_1002410_1002500" /HighExp="Diami, T0.30H, G150, Oxctl, Gly, Paraq, dia5, BC, B60, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S321" CDS 904663..905487 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycerol permease" /protein_id="NP_388809.1" /db_xref="EnsemblGenomes-Gn:BSU09280" /db_xref="EnsemblGenomes-Tr:CAB12756" /db_xref="GOA:P18156" /db_xref="InterPro:IPR000425" /db_xref="InterPro:IPR022357" /db_xref="InterPro:IPR023271" /db_xref="SubtiList:BG10186" /db_xref="UniProtKB/Swiss-Prot:P18156" /translation="MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFQSGWIVVVFGW GLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIIYL HYLPHWKSTDDPAAKLGVFSTGPSIPHTFANVLSEVIGTFVLVLGILAIGANQFTEGL NPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGKGSSNWKYAWVPVVG PILGGSFGGVFYNAAFKGHITSSFWIVSVILVVVLLGLYVYTKSHSAKTLSNSKYI*" /label="glpF CDS" gene 904663..905487 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /label="glpF gene" CDS 905506..906996 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /EC_number="2.7.1.30" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9972264, 10920256, 11929549, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol kinase (sn-glycerol-3-phosphate generating)" /protein_id="NP_388810.2" /db_xref="EnsemblGenomes-Gn:BSU09290" /db_xref="EnsemblGenomes-Tr:CAB12757" /db_xref="GOA:P18157" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005999" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10187" /db_xref="UniProtKB/Swiss-Prot:P18157" /translation="METYILSLDQGTTSSRAILFNKEGKIVHSAQKEFTQYFPHPGWV EHNANEIWGSVLAVIASVISESGISASQIAGIGITNQRETTVVWDKDTGSPVYNAIVW QSRQTSGICEELREKGYNDKFREKTGLLIDPYFSGTKVKWILDNVEGAREKAEKGELL FGTIDTWLIWKMSGGKAHVTDYSNASRTLMFNIYDLKWDDELLDILGVPKSMLPEVKP SSHVYAETVDYHFFGKNIPIAGAAGDQQSALFGQACFEEGMGKNTYGTGCFMLMNTGE KAIKSEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGLRMFQDSSLSESYAEK VDSTDGVYVVPAFVGLGTPYWDSDVRGSVFGLTRGTTKEHFIRATLESLAYQTKDVLD AMEADSNISLKTLRVDGGAVKNNFLMQFQGDLLNVPVERPEINETTALGAAYLAGIAV GFWKDRSEIANQWNLDKRFEPELEEEKRNELYKGWQKAVKAAMAFK*" /label="glpK CDS" gene 905506..906996 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /label="glpK gene" promotor_-35 906307..906313 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 906328..906347 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-10" upshifts 906338 /Source="Nicolas_upshifts" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="upshifts" S_feature 906997..907085 /Source="Nicolas_S_feature" /locus_tag="new_1004835_1004923" /HighExp="Sw, Etha, Salt, G150, Gly, Diami, T0.30H, B60, BC, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S322" downshifts 907042 /Source="Nicolas_upshifts" /id="D480" /incds=0 /nref=34 /ntot=91 /MaxReadThrough="7.63856" /MaxDrop="5.2045" /score="21.1943866" /energy="-28.7" /TU="U728,U729" /idTUdmin="U727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 907048..907148 /Source="Nicolas_upshift_promotors" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 907108 /Source="Nicolas_upshifts" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" CDS 907137..908804 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /EC_number="1.1.3.21" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2127799, 8825777, 9595668, 10633102, 18946204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2127799, 8825777, 9595668, 10633102, 18946204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate oxidase (FAD-dependent)" /protein_id="NP_388811.2" /db_xref="EnsemblGenomes-Gn:BSU09300" /db_xref="EnsemblGenomes-Tr:CAB12758" /db_xref="GOA:P18158" /db_xref="InterPro:IPR000447" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR031656" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10188" /db_xref="UniProtKB/Swiss-Prot:P18158" /translation="MMNHQFSSLERDRMLTDMTKKTYDLFIIGGGITGAGTALDAASR GMKVALSEMQDFAAGTSSRSTKLVHGGLRYLKQFEVKMVAEVGKERAIVYENGPHVTT PEWMLLPFHKGGTFGSFTTSIGLRVYDFLAGVKKSERRSMLSAKETLQKEPLVKKDGL KGGGYYVEYRTDDARLTIEVMKEAVKFGAEPVNYSKVKELLYEKGKAVGVLIEDVLTK KEYKVYAKKIVNATGPWVDQLREKDHSKNGKHLQHTKGIHLVFDQSVFPLKQAVYFDT PDGRMVFAIPREGKTYVGTTDTVYKEALEHPRMTTEDRDYVIKSINYMFPELNITAND IESSWAGLRPLIHEEGKDPSEISRKDEIWTSDSGLITIAGGKLTGYRKMAEHIVDLVR DRLKEEGEKDFGPCKTKNMPISGGHVGGSKNLMSFVTAKTKEGIAAGLSEKDAKQLAI RYGSNVDRVFDRVEALKDEAAKRNIPVHILAEAEYSIEEEMTATPADFFVRRTGRLFF DINWVRTYKDAVIDFMSERFQWDEQAKNKHTENLNKLLHDAVVPLEQ*" /label="glpD CDS" gene 907137..908804 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /label="glpD gene" promotor_-35 908566..908571 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 908586..908604 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-10" upshifts 908595 /Source="Nicolas_upshifts" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="upshifts" promotor_-35 908649..908655 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 908670 /Source="Nicolas_upshifts" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 908671..908689 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 908772 /Source="Nicolas_upshifts" /id="D481" /incds=0 /nref=13 /ntot=60 /MaxReadThrough="6.57605" /MaxDrop="4.31183" /score="11.5542287" /energy="-11.4" /TU="U728,U729,U730,U731,U732" /idTUdmin="U729" /TUdmin="-118" /isTUend="FALSE" /label="downshifts" S_feature 908817..908890 /Source="Nicolas_S_feature" /locus_tag="new_1006655_1006728" /HighExp="G150, Etha, Oxctl, H2O2, Gly, Diami, Paraq, Salt, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF, Sig-, SigB, SigA" /TUshortPSig="1, 0.995, 0.155, 1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S323" promotor_-35 908872..908879 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 908892 /Source="Nicolas_upshifts" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 908893..908912 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 908936..910681 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /EC_number="5.4.2.2" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15640167, 17662947, 24097947, 26735940, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15640167, 17662947, 24097947, 26735940, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-phosphoglucomutase" /protein_id="NP_388812.2" /db_xref="EnsemblGenomes-Gn:BSU09310" /db_xref="EnsemblGenomes-Tr:CAB12759" /db_xref="GOA:P18159" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG10189" /db_xref="UniProtKB/Swiss-Prot:P18159" /translation="MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEF GTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQGEEAKKRGVVIAYDSRHKSPEFA MEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGD DGGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSI SVHPELSEEVDVKVVFTPLHGTANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSP NPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKYTVLTGNQTGALLLH YLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEA SGQYTFQFGYEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNE YGFYREGLKSLTLKGKQGAEQIEAILASFRQNPPQKMAGKQVVTAEDYAVSKRTLLTE SKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKRLAVLSE DVMKTVDEIVESTAK*" /label="pgcA CDS" gene 908936..910681 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /label="pgcA gene" downshifts 910670 /Source="Nicolas_upshifts" /id="D482" /incds=0 /nref=227 /ntot=264 /MaxReadThrough="4.80136" /MaxDrop="5.89896" /score="26.7163878" /energy="-13" /TU="U732,U733" /idTUdmin="U728" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" S_feature 910715..910784 /Source="Nicolas_S_feature" /locus_tag="new_1008553_1008622" /HighExp="Etha, H2O2, B36, dia15, Paraq, G150, LoTm, S8, Oxctl, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S324" misc_feature 910786..910805 /Source="Nicolas_upshift_promotors" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 910786 /Source="Nicolas_upshifts" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" CDS 910830..911969 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YhcZ]" /protein_id="NP_388813.1" /db_xref="EnsemblGenomes-Gn:BSU09320" /db_xref="EnsemblGenomes-Tr:CAB12760" /db_xref="GOA:O07527" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13005" /db_xref="UniProtKB/Swiss-Prot:O07527" /translation="MSKTRMEKLKTLKTIAETLNQGHDIKATLDEVLKELLSLTNLQS GWIFLIEEDGSYTLAADAYLPPALSRKEKVLMCEGECYCLTKFNNGGLRKAANIMNCK RIESAENLHCFDTEGITHHATVPLEDGDRRFGLLNVAAAGKTMFDEEELHLLESVAFQ IGTAIQRMRLSEYQQKNALLMERNRLAQELHDSVNQMLFSVSLTAKAAKTLTKDENLQ QMIDFIQNLSQDALAEMKALIWQLRPGGLEKGLAEAIKSYGALIGLKIIFTQKGCPVL TDEQEHMLWRVVQEALNNCKKHAGTDTAYVSLTASLCHAELDIIDHGAGFRYEAHAGL PSLGIKGMKERAEKAGAKFWIESALGTGTKLSIRLPLKSRKGGAV*" /label="yhcY CDS" gene 910830..911969 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /label="yhcY gene" CDS 911966..912610 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YhcY]" /protein_id="NP_388814.1" /db_xref="EnsemblGenomes-Gn:BSU09330" /db_xref="EnsemblGenomes-Tr:CAB12761" /db_xref="GOA:O07528" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13006" /db_xref="UniProtKB/Swiss-Prot:O07528" /translation="MKIVIADDHHVVRKGLRFFFATQDDIEVVGEAATGLEALRVIEE TKPDLVLMDLSMPEMDGIQAIKKAIQQFPDTNIIVLTSYSDQEHVIPALQAGAKAYQL KDTEPEELVKTRQVHGGEYKLSTAIMPHVLTHMKNQHDPEKEKYYQLTRREKDVLTEI ANGKSNKEIAAALFISEKTVKTHVSNLLAKLEVADRTQAALFAVKYNLNGEISK*" /label="yhcZ CDS" gene 911966..912610 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /label="yhcZ gene" CDS 912607..913131 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /EC_number="1.7.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15184374, 16816187, 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidoreductase, NAD(P)H-FMN and ferric iron reductase (azoreductase)" /protein_id="NP_388815.1" /db_xref="EnsemblGenomes-Gn:BSU09340" /db_xref="EnsemblGenomes-Tr:CAB12762" /db_xref="GOA:O07529" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1NNI" /db_xref="PDB:2GSW" /db_xref="PDB:3GFQ" /db_xref="PDB:3GFR" /db_xref="PDB:3GFS" /db_xref="SubtiList:BG13007" /db_xref="UniProtKB/Swiss-Prot:O07529" /translation="MNMLVINGTPRKHGRTRIAASYIAALYHTDLIDLSEFVLPVFNG EAEQSELLKVQELKQRVTKADAIVLLSPEYHSGMSGALKNALDFLSSEQFKYKPVALL AVAGGGKGGINALNNMRTVMRGVYANVIPKQLVLDPVHIDVENATVAENIKESIKELV EELSMFAKAGNPGV*" /label="azr CDS" gene 912607..913131 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /label="azr gene" downshifts 913096 /Source="Nicolas_upshifts" /id="D483" /incds=0 /nref=72 /ntot=215 /MaxReadThrough="2.90096" /MaxDrop="4.78561" /score="27.1269177" /energy="-17.2" /TU="NA" /idTUdmin="U734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(913146..913388) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388816.1" /db_xref="EnsemblGenomes-Gn:BSU09350" /db_xref="EnsemblGenomes-Tr:CAB12763" /db_xref="InterPro:IPR025431" /db_xref="SubtiList:BG13008" /db_xref="UniProtKB/Swiss-Prot:O07530" /translation="MDYADYDKALYYTHRSQWDNLLILMVRTEDDLLSKRIEHFLHAY HFEQDYAVLEKMLYSLLRYIDHATELTYEDQIALLT*" /label="yhdB CDS" gene complement(913146..913388) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /label="yhdB gene" downshifts complement(913167) /Source="Nicolas_upshifts" /id="D484" /incds=0 /nref=39 /ntot=84 /MaxReadThrough="-0.0235599999999998" /MaxDrop="7.78706" /score="12.0066876" /energy="-17.2" /TU="NA" /idTUdmin="U735" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(913424..913435) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(913435) /Source="Nicolas_upshifts" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(913449..913456) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 913523..913529 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 913543..913554 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 913553 /Source="Nicolas_upshifts" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="upshifts" CDS 913589..913912 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388817.1" /db_xref="EnsemblGenomes-Gn:BSU09360" /db_xref="EnsemblGenomes-Tr:CAB12764" /db_xref="InterPro:IPR024987" /db_xref="SubtiList:BG13009" /db_xref="UniProtKB/Swiss-Prot:O07531" /translation="MKSLPYTIALLFCGLIIVSMAAKGHSTDTDESVQKWEQLAWSKI QDEYKGASFSDYAYMGRTEVNDQQTKDVFRVTVRQKDDTFSVRAEVYFHPVTNHMISI NVFRL*" /label="yhdC CDS" gene 913589..913912 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /label="yhdC gene" S_feature 913913..915779 /Source="Nicolas_S_feature" /locus_tag="new_1011751_1013617" /HighExp="S8, S5, S7, S6, S4, C30, Sw, ferm, S3, BC" /AntisenseName="lytF" /AntisenseCor="-0.65564579825076796" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S325" CDS complement(913954..915420) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10206711, 14594841, 18761694, 18761696, 23091053, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10206711, 14594841, 18761694, 18761696, 23091053, 25288647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamate-meso-diaminopimelate muropeptidase (major autolysin, vegetative)" /protein_id="NP_388818.2" /db_xref="EnsemblGenomes-Gn:BSU09370" /db_xref="EnsemblGenomes-Tr:CAB12776" /db_xref="GOA:O07532" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13010" /db_xref="UniProtKB/Swiss-Prot:O07532" /translation="MKKKLAAGLTASAIVGTTLVVTPAEAATIKVKSGDSLWKLAQTY NTSVAALTSANHLSTTVLSIGQTLTIPGSKSSTSSSTSSSTTKKSGSSVYTVKSGDSL WLIANEFKMTVQELKKLNGLSSDLIRAGQKLKVSGTVSSSSSSSKKSNSNKSSSSSSK SSSNKSSSSSSSTGTYKVQLGDSLWKIANKVNMSIAELKVLNNLKSDTIYVNQVLKTK SSGSDTSSKDNSSKSNQTSATTKYTVKSGDSLWKIANNYNLTVQQIRNINNLKSDVLY VGQVLKLTGKASSGSSSSSSSSSNASSGTTTTYTVKSGDSLWVIAQKFNVTAQQIREK NNLKTDVLQVGQKLVISGKASSSSSSGSSNTTSSTSAKINTMISAAKAQLGVPYRWGG TTPSGFDCSGFIYYVLNKVTSVSRLTAAGYWNTMKSVSQPAVGDFVFFSTYKAGPSHV GIYLGNGEFINANDSGVVISNMNNSYWKQRYLGAKRYF*" /label="lytF CDS" gene complement(913954..915420) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /label="lytF gene" downshifts complement(913966) /Source="Nicolas_upshifts" /id="D485" /incds=0 /nref=121 /ntot=216 /MaxReadThrough="2.34529" /MaxDrop="4.33563" /score="24.6732339" /energy="-14.2" /TU="NA" /idTUdmin="U737" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(914053) /Source="Nicolas_upshifts" /id="D486" /incds=1 /nref=1 /ntot=87 /MaxReadThrough="5.73069" /MaxDrop="2.6306" /score="24.6732339" /energy="-14.2" /TU="U737" /idTUdmin="U737" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(915460..915478) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(915472) /Source="Nicolas_upshifts" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(915492..915499) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(915573..916013) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033; Product type r: regulator" /codon_start=1 /transl_table=11 /product="NO-dependent activator of the ResDE regulon (Fe-S NO binding site)" /protein_id="NP_388819.1" /db_xref="EnsemblGenomes-Gn:BSU09380" /db_xref="EnsemblGenomes-Tr:CAB12777" /db_xref="GOA:O07573" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13011" /db_xref="UniProtKB/Swiss-Prot:O07573" /translation="MKLTNYTDYSLRVLIFLAAERPGELSNIKQIAETYSISKNHLMK VIYRLGQLGYVETIRGRGGGIRLGMDPEDINIGEVVRKTEDDFNIVECFDANKNLCVI SPVCGLKHVLNEALLAYLAVLDKYTLRDLVKNKEDIMKLLKMKE*" /label="nsrR CDS" gene complement(915573..916013) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /label="nsrR gene" downshifts complement(915603) /Source="Nicolas_upshifts" /id="D487" /incds=0 /nref=205 /ntot=265 /MaxReadThrough="3.11158" /MaxDrop="6.87147" /score="5.96186156" /energy="-7.8" /TU="U739" /idTUdmin="U740" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" promotor_-35 916001..916007 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 916021..916032 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 916023..916133 /Source="Nicolas_S_feature" /locus_tag="new_1013861_1013971" /HighExp="S8, S7, S4, Sw, S5, S6, BC, B60, nit, Pyr" /AntisenseName="ygxB" /AntisenseCor="-0.211236686077168" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.904" /TUlongSig="NA" /TUlongPSig="NA" /label="S326" upshifts 916023 /Source="Nicolas_upshifts" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(916035..916054) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(916051) /Source="Nicolas_upshifts" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(916066..916072) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 916092 /Source="Nicolas_upshifts" /id="D488" /incds=0 /nref=10 /ntot=68 /MaxReadThrough="1.05981" /MaxDrop="6.25571" /score="22.5171081" /energy="-11.6" /TU="NA" /idTUdmin="U738" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(916120..917778) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388820.1" /db_xref="EnsemblGenomes-Gn:BSU09390" /db_xref="EnsemblGenomes-Tr:CAB12778" /db_xref="GOA:P37874" /db_xref="InterPro:IPR008910" /db_xref="SubtiList:BG10181" /db_xref="UniProtKB/Swiss-Prot:P37874" /translation="MYEPARQKMIVSLGQEKIPPAHSSVCLLDKWVNTHHTTKKERYQ LNVADVFSSYLSKLPNVIIALLVLLIGWAIAKIIEKAVYKGLSKTKIDDKLFAGKKPS RYSSEKVISKVVYFIALIIVFILFFNILHLTTVASPFVSMLSAIAAAIPSVLKAGLIL LLGWAAASVLSFLVKKIGMKLNTSDKLRKWNLVSEGKDIHQAVNTASQIVFYLVLLVF LPGVLSSLKISGISGPFTNMMESVLAFLPKLFAAALIVLIGWLVARLVRDIITNFLAS IGTERFAARMGLSIYLKDTSLSAVIGTIAYVLIMIPVVISALDQLDVAGISKPAVSML NTILNMLPNIMIAIVLVLAGIWAGKWVKSMVSGLLHRAGFDSVLGKMGMEAGTPAKLS LSQVVGMIAQIIVILLFTAEALQIVRLHFLVEIATGIIAYLPNVLVAVFILGLGLYAG ELVRKVLASMIKGQEFKSLAPIAKYTIIALAFFMALDQLGVAATIVNSAFIIVLSGFA LAFGLSFGLGGKDFASRYLSTFERKMQNTEIEKNRKNQNPPNDM*" /label="ygxB CDS" gene complement(916120..917778) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /label="ygxB gene" downshifts complement(916125) /Source="Nicolas_upshifts" /id="D489" /incds=0 /nref=6 /ntot=40 /MaxReadThrough="8.34865" /MaxDrop="5.55332" /score="-5.46969987" /energy="-14.5" /TU="U740" /idTUdmin="U740" /TUdmin="-532" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(917669..917687) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(917689) /Source="Nicolas_upshifts" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(917701..917707) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 917750..917755 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 917771..917789 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 917784 /Source="Nicolas_upshifts" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="upshifts" CDS 917809..919215 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8144469, 14680823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8144469, 14680823; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation, conserved in non sporulating bacteria" /protein_id="NP_388821.1" /db_xref="EnsemblGenomes-Gn:BSU09400" /db_xref="EnsemblGenomes-Tr:CAB12779" /db_xref="GOA:P37875" /db_xref="InterPro:IPR007390" /db_xref="SubtiList:BG10182" /db_xref="UniProtKB/Swiss-Prot:P37875" /translation="MNAEEKKGLQRAIEEITEIAKGFGLDFYPMRYEICPAEIIYTFG AYGMPTRFSHWSFGKQFHKMKLHYDLGLSKIYELVINSDPCYAFLLDSNSLIQNKLIV AHVLAHCDFFKNNCRFQNTKRDMVESMAATAERIKHYEQVHGIKEVESFLDAILSIQE HIDPSLVRPKLQWSVDDEEEEIEEAATPYDDLWSLDEKKPKKQVKKSKKPFPPRPEKD ILLFIEEHSRELEPWQRDILTMMREEMLYFWPQLETKIMNEGWASYWHQRIIRELDLT SDEAIEFAKLNAGVVQPSKTGINPYYLGLKIFEDIEKRYNNPTEEMKKMGVQPDSGRE KMFEVREIESDISFIRNYLTKELVMREDLYLFQKQGRDYKIIDKQWKSVRDQLVSMRV NGGFPYLTVNDGDYMKNNELYIKHWYEGIELDLKYLEKVLPYLFQLWGRSVHIESVLE DKEVMFSYDGKGVHRRYL*" /label="spoVR CDS" gene 917809..919215 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /label="spoVR gene" downshifts 919195 /Source="Nicolas_upshifts" /id="D490" /incds=0 /nref=43 /ntot=84 /MaxReadThrough="1.30719" /MaxDrop="6.74388" /score="26.4488835" /energy="-11.5" /TU="NA" /idTUdmin="U741" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(919245..920630) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8830275, 10913081, 12897025, 16491025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830275, 10913081, 12897025, 16491025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase A" /protein_id="NP_388822.2" /db_xref="EnsemblGenomes-Gn:BSU09410" /db_xref="EnsemblGenomes-Tr:CAB12780" /db_xref="GOA:P19406" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10183" /db_xref="UniProtKB/Swiss-Prot:P19406" /translation="MKKMSLFQNMKSKLLPIAAVSVLTAGIFAGAELQQTEKASAKKQ DKAEIRNVIVMIGDGMGTPYIRAYRSMKNNGDTPNNPKLTEFDRNLTGMMMTHPDDPD YNITDSAAAGTALATGVKTYNNAIGVDKNGKKVKSVLEEAKQQGKSTGLVATSEINHA TPAAYGAHNESRKNMDQIANSYMDDKIKGKHKIDVLLGGGKSYFNRKDRNLTKEFKQA GYSYVTTKQALKKNKDQQVLGLFADGGLAKALDRDSKTPSLKDMTVSAIDRLNQNKKG FFLMVEGSQIDWAAHDNDTVGAMSEVKDFEQAYKAAIEFAKKDKHTLVIATADHTTGG FTIGANGEKNWHAEPILSAKKTPEFMAKKISEGKPVKDVLARYANLKVTSEEIKSVEA AAQADKSKGASKAIIKIFNTRSNSGWTSTDHTGEEVPVYAYGPGKEKFRGLINNTDQA NIIFKILKTGK*" /label="phoA CDS" gene complement(919245..920630) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /label="phoA gene" downshifts complement(919271) /Source="Nicolas_upshifts" /id="D491" /incds=0 /nref=51 /ntot=178 /MaxReadThrough="1.90638" /MaxDrop="5.795" /score="22.2126775" /energy="-13.2" /TU="NA" /idTUdmin="U742" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(920657) /Source="Nicolas_upshifts" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(920659..922190) /Source="Nicolas_S_feature" /locus_tag="new_1018497_1020028_c" /HighExp="Etha, Salt, B60, Heat, M9-stat, T5.0H, T0.30H, T4.0H, T3.30H, T2.30H" /AntisenseName="lytE" /AntisenseCor="-0.65081062481616203" /AntisenseRegPval="-33.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="0.966, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S327" misc_feature complement(920667..920678) /Source="Nicolas_upshift_promotors" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 920786..920793 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 920806..920825 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 920812..921099 /Source="Nicolas_S_feature" /locus_tag="new_1018650_1018937" /HighExp="T-5.40H, Cold, LoTm, T-4.40H, UNK1, T5.0H, GM-0.1, T3.30H, S1, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S328" upshifts 920812 /Source="Nicolas_upshifts" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 921062..921065 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 921080..921099 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 921101 /Source="Nicolas_upshifts" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="upshifts" CDS 921160..922164 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 16950129, 9457885, 21541672, 22139507, 27002131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 16950129, 9457885, 21541672, 22139507, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin)" /protein_id="NP_388823.2" /db_xref="EnsemblGenomes-Gn:BSU09420" /db_xref="EnsemblGenomes-Tr:CAB12781" /db_xref="GOA:P54421" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11406" /db_xref="UniProtKB/Swiss-Prot:P54421" /translation="MKKQIITATTAVVLGSTLFAGAASAQSIKVKKGDTLWDLSRKYD TTISKIKSENHLRSDIIYVGQTLSINGKSTSSKSSSSSSSSSTYKVKSGDSLWKISKK YGMTINELKKLNGLKSDLLRVGQVLKLKGSTSSSSSSSSKVSSSSTSTYKVKSGDSLS KIASKYGTTVSKLKSLNGLKSDVIYVNQVLKVKGTSTSSSKPASSSSSSSSKTSSTSL NVSKLVSDAKALVGTPYKWGGTTTSGFDCSGFIWYVLNKQTSVGRTSTAGYWSSMKSI ASPSVGDFVFFTTYKSGPSHMGIYIGNNSFIHAGSDGVQISSLNNSYWKPRYLGAKRF *" /label="lytE CDS" gene 921160..922164 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /label="lytE gene" downshifts 922026 /Source="Nicolas_upshifts" /id="D492" /incds=1 /nref=1 /ntot=117 /MaxReadThrough="6.89938" /MaxDrop="2.1687" /score="26.3320532" /energy="-9.8" /TU="U743,U744" /idTUdmin="U743" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 922156 /Source="Nicolas_upshifts" /id="D493" /incds=0 /nref=53 /ntot=190 /MaxReadThrough="3.64545" /MaxDrop="6.08377" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" upshifts complement(922190) /Source="Nicolas_upshifts" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(922197..922212) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 922202 /Source="Nicolas_upshifts" /id="D494" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="2.99" /MaxDrop="3.76174" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(922224..922233) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(922235..923110) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8045899, 10869065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045899, 10869065; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator CitR (LysR family)" /protein_id="NP_388824.2" /db_xref="EnsemblGenomes-Gn:BSU09430" /db_xref="EnsemblGenomes-Tr:CAB12782" /db_xref="GOA:P39127" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10853" /db_xref="UniProtKB/Swiss-Prot:P39127" /translation="MDFKWLHTFVTAAKYENFRKTAETLFLSQPTVTVHIKQLEKEIS CKLFERKGRQIQLTDEGRAYLPYALRLLDDYENSMAELHRVRQGYSQTLQLAVSPLIA DTVLPSVMKRYTAMNTETEMAVTIFESAEIASLIKAGEADIGLSCLKVQSSSLSCHCL YKDPVVLVAPPDKRFIEDNEIDAKEVLEQYLLLTHNHPDYWDDLLRQVRMTFPFVRTM KVTQTHITKRFIKEGLGVSFLPLSTVKRELAEKQMIRIPYQSVQLPYAGAYAIALYEN KKEKKFLDFLSHFHF*" /label="citR CDS" gene complement(922235..923110) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /label="citR gene" promotor_-35 923163..923164 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(923176..923195) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-10" promotor_-10 923181..923200 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(923182) /Source="Nicolas_upshifts" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="upshifts" upshifts 923191 /Source="Nicolas_upshifts" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(923210..923215) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-35" CDS 923219..924319 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:4211224, 8045898, 8045899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4211224, 8045898, 8045899; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase I" /protein_id="NP_388825.2" /db_xref="EnsemblGenomes-Gn:BSU09440" /db_xref="EnsemblGenomes-Tr:CAB12783" /db_xref="GOA:P39119" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR016143" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="PDB:2C6X" /db_xref="SubtiList:BG10854" /db_xref="UniProtKB/Swiss-Prot:P39119" /translation="MVHYGLKGITCVETSISHIDGEKGRLIYRGHHAKDIALNHSFEE AAYLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVLRTVVSALG ENTYTFHPKTEEAIRLIAITPSIIAYRKRWTRGEQAIAPSSQYGHVENYYYMLTGEQP SEAKKKALETYMILATEHGMNASTFSARVTLSTESDLVSAVTAALGTMKGPLHGGAPS AVTKMLEDIGEKEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAEALRQKAEEVAGND RDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDDELFTPTFSASRMV GWCAHVLEQAENNMIFRPSAQYTGAIPEEVLS*" /label="citA CDS" gene 923219..924319 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /label="citA gene" promotor_-35 924330..924336 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 924351..924369 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 924356 /Source="Nicolas_upshifts" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 924393..925262 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 18643936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)-dependent dehydrogenase" /protein_id="NP_388826.1" /db_xref="EnsemblGenomes-Gn:BSU09450" /db_xref="EnsemblGenomes-Tr:CAB12784" /db_xref="GOA:O07575" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13012" /db_xref="UniProtKB/Swiss-Prot:O07575" /translation="MNPMDRQTEGQEPQHQDRQPGIESKMNPLPLSEDEDYRGSGKLK GKVAIITGGDSGIGRAAAIAFAKEGADISILYLDEHSDAEETRKRIEKENVRCLLIPG DVGDENHCEQAVQQTVDHFGKLDILVNNAAEQHPQDSILNISTEQLEKTFRTNIFSMF HMTKKALPHLQEGCAIINTTSITAYEGDTALIDYSSTKGAIVSFTRSMAKSLADKGIR VNAVAPGPIWTPLIPATFPEEKVKQHGLDTPMGRPGQPVEHAGAYVLLASDESSYMTG QTIHVNGGRFIST*" /label="yhdF CDS" gene 924393..925262 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /label="yhdF gene" downshifts 925270 /Source="Nicolas_upshifts" /id="D495" /incds=0 /nref=27 /ntot=130 /MaxReadThrough="8.65426" /MaxDrop="6.48064" /score="18.1511963" /energy="-8.2" /TU="U748" /idTUdmin="U747" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 925347..925350 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 925362 /Source="Nicolas_upshifts" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 925365..925384 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 925410..925429 /Source="Nicolas_upshift_promotors" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 925415..925511 /Source="Nicolas_S_feature" /locus_tag="new_1023253_1023349" /HighExp="Etha, T2.30H, T-0.40H, T2.0H, T1.30H, S1, GM-0.2, T3.0H, T-1.40H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.27332800000000002" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.522, 0.998, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S329" upshifts 925415 /Source="Nicolas_upshifts" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" CDS 925512..926909 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16621821, 16850406, 21097623, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16621821, 16850406, 21097623, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid transporter or methylthioribose-degradation metabolite exporter" /protein_id="NP_388827.1" /db_xref="EnsemblGenomes-Gn:BSU09460" /db_xref="EnsemblGenomes-Tr:CAB12785" /db_xref="GOA:O07576" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004758" /db_xref="SubtiList:BG13013" /db_xref="UniProtKB/Swiss-Prot:O07576" /translation="MKGSVFRKKSIQDLIAATSGEKSLKRELGAFDLTLLGIGAIIGT GIFVLTGTGAVTAGPGLTISFVVAALACLFAALSYAEFASSVPVSGSVYTFTYATLGE LMAFIIGWDLILEYMLAVSAVSVGWSGYFQSFLSGLGIHLPVALTAAPGAVKGTFTLF NLPAFVIVMAITYLLYLGIKESKRVNNIMVILKILVVLLFIAVAAVYVKPHNWQPFMP MGFGGVFSAAALVFFAFIGFDAVSSAAEETKNPAKDLPKGIIFSLLVCTILYVTVSAI MTGVIPFAQFAGVDHPVSLVLQSAGQNWVAGIIDIGAVLGMTTVMLVMLYGQTRVMFA MSRDGLVPGSLSKVHPKHKTPYVATWFFGTMSALLGSLVPLDELAKLVNIGTLSAFVL ISVAVIVLRKKQPDLPRAFKCPGVPVIPGLAILFCLFLILNLGWVTIVRFLVWLLIGL VIYFLYSRKHSKLNQ*" /label="bcaP CDS" gene 925512..926909 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /label="bcaP gene" downshifts 926889 /Source="Nicolas_upshifts" /id="D496" /incds=0 /nref=116 /ntot=188 /MaxReadThrough="3.41176" /MaxDrop="5.29633" /score="5.08283681" /energy="-12.3" /TU="U748,U749" /idTUdmin="U750" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 926970..926974 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926990..927009 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926997 /Source="Nicolas_upshifts" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 927027..928382 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_388828.1" /db_xref="EnsemblGenomes-Gn:BSU09470" /db_xref="EnsemblGenomes-Tr:CAB12786" /db_xref="GOA:O07577" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13014" /db_xref="UniProtKB/Swiss-Prot:O07577" /translation="MSEQKPVQWASKIGFVMAAAGSAIGLGAIWKFPYVAGTNGGGAF FLIFVLFTILLGYPLLVGEFIFGRRNQTNAIDAYKKEAPRSAWFLTGWIGVAACFLVL SFYSVIGGWILLYIVKTASGSLSGLSQAQYGALFASIIQNPVQTLAAQLVFMALTVLV VARGVQKGIERVSAVMMPILFLLFILLVLRSLTLNGAMEGVKFLLVPHFGDLTPESIL FALGQAFFTLTLGVSVMVTYSSYLPKTQNIPRSAASIVLMNIIVTLLAGLAIFPAVFS FGFQPNEGPTLLFTVLPAVFEQLPFGTLFFIGFLVAFLFAALTSAFSMVEIIVATIGK GDEKKRKKLSWTSGLLIFLVGIPCCLSYGVLSDVHLFGKTFFDIADFTVSNVLMPSGA LLISLFIPLKISKSELLAEMRNGSNAGKAFFYTWFYLLRFIVPLAIIIVFLNLIGILS F*" /label="yhdH CDS" gene 927027..928382 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /label="yhdH gene" downshifts 928363 /Source="Nicolas_upshifts" /id="D497" /incds=0 /nref=184 /ntot=244 /MaxReadThrough="1.73756" /MaxDrop="6.09379" /score="40.1809389" /energy="-14.8" /TU="NA" /idTUdmin="U751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(928417..929826) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388829.1" /db_xref="EnsemblGenomes-Gn:BSU09480" /db_xref="EnsemblGenomes-Tr:CAB12787" /db_xref="GOA:O07578" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13015" /db_xref="UniProtKB/Swiss-Prot:O07578" /translation="MDITPFLDKKSKTPLYEQLYTFFKQEISHARITKGTRLPSKRRL SSLLDVSTATIERAYEQLTAEGYVKSKPKIGWFAAEVEPGFPTAPDHFQQSVQPGLHQ KNAPAIDFHQGSVDPTLFPFNAWRKSIVKSLDRYSGSFHTSGDPQGEYELRHMIARFV RLSRGVNCEPGQIIIGAGTTVLLQNLCLSLKPGTKIGFEEPGFHRSRRMFEANHMDVT PICSDAEGVLPDELYRQNPYLMYTTPSHQFPIGTIMTITRRQELLAWAAETNSFIIED DYDGEFRYSGHPIPSLQGLDPNGRVIYLGTFSKSLLPSLRLSFMIVPPELMEPIQNNV QLMKQTVSAHSQLALADFIETGEWQKHINRMRSLYRKKHAVLLEAIRSELGNTVEILG KNSGLHILLRLLFPASEEEAIQAAADHGVTLYPVSPSYIEQTPFTSVLIGYGGLSEED IRLGIQKLKTAWAPLISSY*" /label="yhdI CDS" gene complement(928417..929826) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /label="yhdI gene" promotor_-35 929875..929878 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 929893..929912 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 929895 /Source="Nicolas_upshifts" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(929897..929916) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(929909) /Source="Nicolas_upshifts" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(929932..929936) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 929936..930364 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388830.1" /db_xref="EnsemblGenomes-Gn:BSU09490" /db_xref="EnsemblGenomes-Tr:CAB12788" /db_xref="GOA:O07579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13016" /db_xref="UniProtKB/Swiss-Prot:O07579" /translation="MIHMKQLTSKEEWAESYPIMSELRTELDIETYLQRLEACVQKES YMLFALYENTAIRALCGALPRVSIHKGEHLWIADLVTTAPCRSKGYGKMLLDYASDWA RKAGLGFVSLSSGLQRKDAHRFYTDKMGFTIESYLFRKPV*" /label="yhdJ CDS" gene 929936..930364 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /label="yhdJ gene" downshifts 930343 /Source="Nicolas_upshifts" /id="D498" /incds=0 /nref=46 /ntot=213 /MaxReadThrough="1.42962" /MaxDrop="4.77191" /score="24.6412105" /energy="-12.1" /TU="NA" /idTUdmin="U752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(930395..930685) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388831.1" /db_xref="EnsemblGenomes-Gn:BSU09500" /db_xref="EnsemblGenomes-Tr:CAB12789" /db_xref="GOA:O07580" /db_xref="InterPro:IPR020496" /db_xref="SubtiList:BG13017" /db_xref="UniProtKB/Swiss-Prot:O07580" /translation="MELVRIFKEHNVFGWISVGTAVLSLLLLNLAIISNVTFYSYQML PFAMAAVPFGVVELFIKRGRTGPGLLGVILNLFVIICVYTIVSVDTNLQFGF*" /label="asiMB CDS" gene complement(930395..930685) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /label="asiMB gene" downshifts complement(930419) /Source="Nicolas_upshifts" /id="D499" /incds=0 /nref=44 /ntot=229 /MaxReadThrough="2.66153" /MaxDrop="4.72865" /score="26.7359231" /energy="-11.1" /TU="NA" /idTUdmin="U754" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(930673..931749) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388832.1" /db_xref="EnsemblGenomes-Gn:BSU09510" /db_xref="EnsemblGenomes-Tr:CAB12790" /db_xref="GOA:O07581" /db_xref="InterPro:IPR025672" /db_xref="InterPro:IPR029101" /db_xref="SubtiList:BG13018" /db_xref="UniProtKB/Swiss-Prot:O07581" /translation="MMNEEFKKRFDQYKNGEMSDQEMTAFEEELEKLEVYQELIDSEL EDDNDWDLSISPEKQKAILAYGKRKSYLRISVLAVISTLMILPLCTLGSYLYYGMGGK HSTGNEFMETAAVTVALTMPNVLVDTSGLKSQVKLFGMNTEFPLQKQIGTKTAAVGNE RVEMFYNKVKAPAVNYYDLEVNKTGHYFTHPSNKSEQTTAKAEKTLSTLPEGTVSEVY LSYDRAYPTKDVYNKFKGYDVSFLWNAIETEKNTNKTASTEPLGYPGKDSKFLAALNT KGKSNGDQFINALKFMSKHEKWAQVISKRKDLNVDNRLDYVEKNGVNVYGSVVTGPTK EIQRMLKNKSVKSANVGEVELWNW*" /label="asiMA CDS" gene complement(930673..931749) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /label="asiMA gene" CDS complement(931739..932230) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14651641, 14769884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14651641, 14769884; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M))" /protein_id="NP_388833.1" /db_xref="EnsemblGenomes-Gn:BSU09520" /db_xref="EnsemblGenomes-Tr:CAB12791" /db_xref="GOA:O07582" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13019" /db_xref="UniProtKB/Swiss-Prot:O07582" /translation="MTIDEIYQMYMNDVYRFLLSMTKDKHLAEDLLQETFMRAYIHIH SYDHSKVKPWLFQVARNAFIDYVRKHKKEVTISDDLIGSLFQNAVQSPAHQVEIKEVL TGYMSELPDNYREALTLYYLKELNYKEASHIMNISEANFKSVLFRARQRLKALYNRGV NDE*" /label="sigM CDS" gene complement(931739..932230) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /label="sigM gene" S_feature complement(932231..932333) /Source="Nicolas_S_feature" /locus_tag="new_1030069_1030171_c" /HighExp="Cold, LBGstat, H2O2, G180, Paraq, Oxctl, G135, HPh, dia15, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S330" promotor_-10 complement(932322..932341) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(932333) /Source="Nicolas_upshifts" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(932355..932358) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 932371..932377 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 932388 /Source="Nicolas_upshifts" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 932392..932410 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(932421) /Source="Nicolas_upshifts" /id="D500" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="2.13683" /MaxDrop="4.59517" /score="8.96845329" /energy="-10.2" /TU="NA" /idTUdmin="U757" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS 932427..933422 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10220166, 15019785, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15019785, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldo/keto reductase specific for NADPH; protectsagainst methylglyoxal" /protein_id="NP_388834.1" /db_xref="EnsemblGenomes-Gn:BSU09530" /db_xref="EnsemblGenomes-Tr:CAB12792" /db_xref="GOA:P80874" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PZ1" /db_xref="SubtiList:BG13020" /db_xref="UniProtKB/Swiss-Prot:P80874" /translation="MEYTSIADTGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAAL DQGITLIDTAPAYGFGQSEEIVGKAIKEYGKRDQVILATKTALDWKNNQLFRHANRAR IVEEVENSLKRLQTDYIDLYQVHWPDPLVPIEETAEVMKELYDAGKIRAIGVSNFSIE QMDTFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEE YTFEGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADI ALWGARKPGQLEALSEITGWTLNSEDQKDINTILENTISDPVGPEFMAPPTREEI*" /label="akrN CDS" gene 932427..933422 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /label="akrN gene" downshifts 933401 /Source="Nicolas_upshifts" /id="D501" /incds=0 /nref=59 /ntot=160 /MaxReadThrough="6.85446" /MaxDrop="4.90106" /score="10.4379759" /energy="-11.8" /TU="U755" /idTUdmin="U756" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 933484..933487 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 933502..933521 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 933507 /Source="Nicolas_upshifts" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="upshifts" CDS 933557..934156 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /EC_number="2.3.1.51" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1557036, 17557823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1557036, 17557823; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-acylglycerol-phosphate (1-acyl-G3P) acyltransferase" /protein_id="NP_388835.1" /db_xref="EnsemblGenomes-Gn:BSU09540" /db_xref="EnsemblGenomes-Tr:CAB12793" /db_xref="GOA:O07584" /db_xref="InterPro:IPR002123" /db_xref="InterPro:IPR004552" /db_xref="SubtiList:BG13021" /db_xref="UniProtKB/Swiss-Prot:O07584" /translation="MYKFCANALKVILSLRGGVKVYNKENLPADSGFVIACTHSGWVD VITLGVGILPYQIHYMAKKELFQNKWIGSFLKKIHAFPVDRENPGPSSIKTPIKLLKE GEIVGIFPSGTRTSEDVPLKRGAVTIAQMGKAPLVPAAYQGPSSGKELFKKGKMKLII GEPLHQADFAHLPSKERLAAMTEALNQRIKELENKLDQL*" /label="plsC CDS" gene 933557..934156 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /label="plsC gene" downshifts 934171 /Source="Nicolas_upshifts" /id="D502" /incds=0 /nref=189 /ntot=245 /MaxReadThrough="6.36101" /MaxDrop="7.07164" /score="-7.3088084" /energy="-6.1" /TU="U755" /idTUdmin="U756" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 934216..936170 /Source="Nicolas_S_feature" /locus_tag="new_1032054_1034008" /HighExp="Cold, C30, S8, T-4.40H, Sw, Fru, S0, S7, HPh, G135" /AntisenseName="yhdP" /AntisenseCor="-0.46228251493795502" /AntisenseRegPval="-14.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S331" CDS complement(934225..935559) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /function="16.1: Circulate" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 25182490; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative magnesium efflux pump" /protein_id="NP_388836.1" /db_xref="EnsemblGenomes-Gn:BSU09550" /db_xref="EnsemblGenomes-Tr:CAB12794" /db_xref="GOA:O07585" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13022" /db_xref="UniProtKB/Swiss-Prot:O07585" /translation="MDIVNLILVAVLIALTAFFVASEFAIIRIRGSRIDQLIAEGNKA AIAVKKVTTHLDEYLSACQLGITLTSIGLGVLGESTIERLLHPLFVQMNVPGSLSHVI SFIFAYAIITFLHVVVGELAPKTVAIQKAEAVSMLFAKPLIWFYRIAFPFIWLLNNSA RLLTKAFGLETVSENELAHSEEELRIILSESYKSGEINQSEFKYVNKIFEFDDRLAKE IMIPRTEIVSLPHDIKISEMMDIIQIEKYTRYPVEEGDKDNIIGVINIKEVLTACISG EVSVDSTISQFVNPIIHVIESAPIQDLLVKMQKERVHMAILSDEYGGTAGLVTVEDII EEIVGEIRDEFDIDEISEIRKIGEGHYILDGKVLIDQVNDLLGIHLENEEVDTIGGWF LTQKYDVEKDDSIIEEGCEFIINEIDGHHVAYIEVKKLQEEELLETANQQEA*" /label="yhdP CDS" gene complement(934225..935559) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /label="yhdP gene" downshifts complement(934244) /Source="Nicolas_upshifts" /id="D503" /incds=0 /nref=284 /ntot=315 /MaxReadThrough="1.96991" /MaxDrop="7.22379" /score="11.1466394" /energy="-9.1" /TU="NA" /idTUdmin="U757" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" CDS complement(935620..936051) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 18048925" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 18048925; Product type r: regulator" /codon_start=1 /transl_table=11 /product="indirect copper efflux transcriptional regulator" /protein_id="NP_388837.1" /db_xref="EnsemblGenomes-Gn:BSU09560" /db_xref="EnsemblGenomes-Tr:CAB12795" /db_xref="GOA:O07586" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13023" /db_xref="UniProtKB/Swiss-Prot:O07586" /translation="MVGRDIDGAETYRISELAALAGVTKRTVDYYTNLGLLTPARSCS NYRYYDENALKRLIFIVDCKKQRLALSDIKDRLENQFPSSAKLDDEIGNLALEIDHMN QNISGILHRFERLKPEDRDKLKSKLPPEKLAVFQSFMLLLS*" /label="cueR CDS" gene complement(935620..936051) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /label="cueR gene" promotor_-10 complement(936063..936082) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(936073) /Source="Nicolas_upshifts" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(936097..936103) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(936099..936199) /Source="Nicolas_upshift_promotors" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 936134..936141 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-35" upshifts complement(936139) /Source="Nicolas_upshifts" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 936155..936174 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-10" upshifts 936172 /Source="Nicolas_upshifts" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="upshifts" CDS 936208..937389 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965, 15103638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_388838.1" /db_xref="EnsemblGenomes-Gn:BSU09570" /db_xref="EnsemblGenomes-Tr:CAB12796" /db_xref="GOA:O07587" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13024" /db_xref="UniProtKB/Swiss-Prot:O07587" /translation="MKLAGLSREVEENLNKGSWIRKLFDEGARLKKEFGEDQVFDFSL GNPIVEPPEAFKRALIEEAEKGSHGYIQNQGLLAAREKVAQFLGSRFEADFSAERIVM TVGAGGALNVALKSIVNPGEEVIILAPYFAEYKLYIENYGGKAVSCPLTSRFEIDIEA VRQSITPQTKGLILNTPHNPTGTVLSQKNIDDLGALLKEIEEKSGQTIYVLFDEPYSQ LIYDEELANPFQSYHRVILASSFSKDLGIAGERLGYIGLDSRMPDADLLINAFVYCNR TLGFVNAPVMMQRAVARMDDLRVDASAYKERRDLMVDILKEAGFEFEMPKGGFFVFPK SPIEDEVAFCVHAAQKYKLLIVPSSGFGMSGHFRLSFSVPIEQIKNSRDIFISLYKDF A*" /label="yhdR CDS" gene 936208..937389 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /label="yhdR gene" downshifts 937374 /Source="Nicolas_upshifts" /id="D504" /incds=0 /nref=12 /ntot=180 /MaxReadThrough="2.81766" /MaxDrop="3.37889" /score="-5.8634451" /energy="-9.1" /TU="U759" /idTUdmin="U759" /TUdmin="-163" /isTUend="FALSE" /label="downshifts" S_feature 937419..937557 /Source="Nicolas_S_feature" /locus_tag="new_1035257_1035395" /HighExp="Etha, S1, BMM, S2, Cold, MG 45, MG 25, C90, T-5.40H, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S332" misc_feature 937553..937572 /Source="Nicolas_upshift_promotors" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 937559..937715 /Source="Nicolas_S_feature" /locus_tag="new_1035397_1035553" /HighExp="M9-stat, B60, T4.0H, T3.0H, LoTm, S5, T5.0H, S4, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S333" upshifts 937559 /Source="Nicolas_upshifts" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="upshifts" CDS 937716..939101 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388840.1" /db_xref="EnsemblGenomes-Gn:BSU09590" /db_xref="EnsemblGenomes-Tr:CAB12798" /db_xref="GOA:O07589" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13026" /db_xref="UniProtKB/Swiss-Prot:O07589" /translation="MDDIDSLILIGVLIALTAFFVASEFAIVRVRRSRIDQLITEGNK RAILARRVITDLDEYLSASQLGITLTSIGLGVLGEPAFERLLHPLFEPLGLPDSVSHA VSFAVAYGLITFLHVVVGELAPKTVAIQKAEQLTLLIAGPLRLFYLLLFPFIWILNGS ARLLCGMFGLKPASEHDGSHSEEELRMLLSESLKNGEINPSEYKYVNKIFEFDNRIAK EIMIPRKEMAAVSTEMTMAEMLEVMLKEKYTRWPVTDGDKDSVLGLVNTKHLFSDLLF MTEEERMKMTIHPYVRPVIEVIETIPVHDLLIKMQRERIHMAILSDEYGGTSGLVTTE DILEEIVGEIRDEFDEDEQPLIQKLGDGHYVMDGKVRIDQVNSLLGASIQEDVDTIGG LILKENIDIEAGESIRIGSYTIKVLKMDGRLIKQIDIKEEAGNTTGITAHHKLPLPEP VMLNSATLSEK*" /label="yhdT CDS" gene 937716..939101 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /label="yhdT gene" downshifts 938991 /Source="Nicolas_upshifts" /id="D505" /incds=1 /nref=120 /ntot=240 /MaxReadThrough="5.11037" /MaxDrop="3.79021" /score="19.6985636" /energy="-10.5" /TU="U760" /idTUdmin="U760" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 939077 /Source="Nicolas_upshifts" /id="D506" /incds=0 /nref=129 /ntot=245 /MaxReadThrough="1.68999" /MaxDrop="6.12682" /score="19.6985636" /energy="-10.5" /TU="NA" /idTUdmin="U760" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(939115..939471) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 17196979, 22194412, 27824896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fluoride efflux channel component A" /protein_id="NP_388841.1" /db_xref="EnsemblGenomes-Gn:BSU09600" /db_xref="EnsemblGenomes-Tr:CAB12799" /db_xref="GOA:O07590" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13027" /db_xref="UniProtKB/Swiss-Prot:O07590" /translation="MTLAGIFIGGGLGAMLRFWLGNVITAKTKGLSLPIGILTVNILG ALGLGIFTGLHVANASVSLIIGTGFFGAFTTFSTFSVETIQLLMAKRVKESILYIVLT LCGSLFAFWCGWTITI*" /label="crcBA CDS" gene complement(939115..939471) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /label="crcBA gene" CDS complement(939468..939863) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /function="16.1: Circulate" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 22194412, 27824896; Product type t : transporter" /codon_start=1 /transl_table=11 /product="subunit of fluoride efflux transporter" /protein_id="NP_388842.1" /db_xref="EnsemblGenomes-Gn:BSU09610" /db_xref="EnsemblGenomes-Tr:CAB12800" /db_xref="GOA:O07591" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13028" /db_xref="UniProtKB/Swiss-Prot:O07591" /translation="MKIYSAVFIGGALGACLRYGLNLWIHTGQFPAATWLENAAGSLL LGILTGFFMIGAKRPLLSAFLGTGFCGGFTTMSTFSKETVMLLQGQPSLALLYVAASL ISGIIFALIGVFVGRRIAGIQQRKGLQEK*" /label="crcBB CDS" gene complement(939468..939863) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /label="crcBB gene" CDS complement(939850..940581) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /EC_number="3.1.4.46" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8012593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycerophosphodiester phosphodiesterase" /protein_id="NP_388843.1" /db_xref="EnsemblGenomes-Gn:BSU09620" /db_xref="EnsemblGenomes-Tr:CAB12801" /db_xref="GOA:O07592" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG13029" /db_xref="UniProtKB/Swiss-Prot:O07592" /translation="MYIIAHRGASGYAPENTIAAFDLAVKMNADMIELDVQLTKDRQI VVIHDDRVDRTTNGSGFVKDFTLEELQKLDAGSWYGPAFQGERIPTLEAVLKRYHKKI GLLIELKGHPSQVGIEEEVGQLLGQFSFSINNIVQSFQFRSVQRFRELYPSIPTAVIT RPNFGMLSRNQMKAFRSFANYVNIKHTRLNRLMIGSINKNGLNIFAWTVNNQKTAAKL QAMGVDGIVTDYPDFIIKDGKHENI*" /label="yhdW CDS" gene complement(939850..940581) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /label="yhdW gene" misc_feature complement(940606..940625) /Source="Nicolas_upshift_promotors" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(940627) /Source="Nicolas_upshifts" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 940674..940682 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 940691 /Source="Nicolas_upshifts" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 940696..940711 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 940705..940778 /Source="Nicolas_S_feature" /locus_tag="new_1038543_1038616" /HighExp="S5, S4, S6, S7, S8, S3, B60, Pyr, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.563" /TUlongSig="NA" /TUlongPSig="NA" /label="S334" promotor_-35 940765..940766 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 940780 /Source="Nicolas_upshifts" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 940782..940801 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-10" CDS 940815..940922 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388844.1" /db_xref="EnsemblGenomes-Gn:BSU09630" /db_xref="EnsemblGenomes-Tr:CAB12802" /db_xref="InterPro:IPR035384" /db_xref="SubtiList:BG13030" /db_xref="UniProtKB/Swiss-Prot:O07593" /translation="MGKGRIRVEERIKAETDAEMQKATLLDQTQTKKGK*" /label="yhdX CDS" gene 940815..940922 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /label="yhdX gene" S_feature 940923..940976 /Source="Nicolas_S_feature" /locus_tag="new_1038761_1038814" /HighExp="Sw, BC, LPhT, HiOs, S4, HiTm, S5, B36, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S335" downshifts 940947 /Source="Nicolas_upshifts" /id="D507" /incds=0 /nref=177 /ntot=225 /MaxReadThrough="0.97838" /MaxDrop="7.47175" /score="21.9742676" /energy="-14.5" /TU="NA" /idTUdmin="U762" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 941027..941046 /Source="Nicolas_upshift_promotors" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 941033 /Source="Nicolas_upshifts" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 941071..942186 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /function="16.8: Protect" /function="16.12: Sense" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12077558, 15849754, 16850406, 17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12077558, 15849754, 16850406, 17665170, 18310427, 19252899; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small conductance mechano-sensitive channel" /protein_id="NP_388845.1" /db_xref="EnsemblGenomes-Gn:BSU09640" /db_xref="EnsemblGenomes-Tr:CAB12803" /db_xref="GOA:O07594" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR006686" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13031" /db_xref="UniProtKB/Swiss-Prot:O07594" /translation="MPDYLQQYFTLDNIIQIGISLAILLVFLILRKLFTRYFFNLLFN LTNRPKTEIFKQVVLAFDKPARWFFVALGLFLAIRYSPFLDEQMPVISKIYRSLIVAL LCWGLCNLTATSSFIFHKVNQRFELDMDDILAPFLSKLLRFVIIALSVSVIAQEFNYD VNGFVAGLGLGGLAFALAAKDTISNFFGGIIIITEKPFTIGDWVETSTVTGSVEDITF RSTRFRTAQGALVTVPNSTLSMEAITNWTRMTKRQITFSIHVSYATPIENLERSIHSL RTMLLEHEGVDNEIIMVNFDTFADSYYNLFFNFYTKTTVWAENLNIREDINYKIIEIL GAEGVQFAYPGQMVVVKQKHESDQFQVNLNKEEKERA*" /label="mscY CDS" gene 941071..942186 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /label="mscY gene" downshifts 942166 /Source="Nicolas_upshifts" /id="D508" /incds=0 /nref=5 /ntot=141 /MaxReadThrough="3.45709" /MaxDrop="3.93891" /score="2.31392404" /energy="-12.3" /TU="U764" /idTUdmin="U764" /TUdmin="-783" /isTUend="FALSE" /label="downshifts" misc_feature 942223..942242 /Source="Nicolas_upshift_promotors" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 942223 /Source="Nicolas_upshifts" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 942256..942999 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16768447, 19136592, 26708127, 27987242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16768447, 19136592, 26708127, 27987242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirtuin NAD-dependent deacetylase" /protein_id="NP_388846.1" /db_xref="EnsemblGenomes-Gn:BSU09650" /db_xref="EnsemblGenomes-Tr:CAB12804" /db_xref="GOA:O07595" /db_xref="InterPro:IPR003000" /db_xref="InterPro:IPR026590" /db_xref="InterPro:IPR028628" /db_xref="InterPro:IPR029035" /db_xref="SubtiList:BG13032" /db_xref="UniProtKB/Swiss-Prot:O07595" /translation="METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASR MEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNI DGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVL KTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIIN LEPTYCDSLFDMVIHQKIGEFARSLGMKK*" /label="srtN CDS" gene 942256..942999 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /label="srtN gene" downshifts 942971 /Source="Nicolas_upshifts" /id="D509" /incds=0 /nref=3 /ntot=82 /MaxReadThrough="1.93149" /MaxDrop="2.85561" /score="9.76884826" /energy="-9.2" /TU="NA" /idTUdmin="U765" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(943023..943871) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide deacetylase" /protein_id="NP_388847.1" /db_xref="EnsemblGenomes-Gn:BSU09660" /db_xref="EnsemblGenomes-Tr:CAB12805" /db_xref="GOA:O07596" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG13046" /db_xref="UniProtKB/Swiss-Prot:O07596" /translation="MRQTRGEASPSAVSLAFKFASLAVLCVLLLLMVILGYSNSSTKA KEVTVTTNGQLRDEKESLKLKNDSPDLLIKHLQTKQNMGDKTVYLTFDDGPSAVTTRL LDVLKSADVKATFFMLSPRMNEFKQAVKRAEKEGHALGLHGVTHNNRLFYQTPTSPLK EMQEARDTLQDITGYKTDLVRTPYGSKPSLTASQIRNLEKDGFVYWDWTIDSMDWKYR NSQYVTAVLQQLENMEHSSSSRPNVILMHDLPATVNALPVLINKLKEKGYSFGVLEDT MVPVHE*" /label="yheN CDS" gene complement(943023..943871) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /label="yheN gene" downshifts complement(943047) /Source="Nicolas_upshifts" /id="D510" /incds=0 /nref=126 /ntot=242 /MaxReadThrough="2.03966" /MaxDrop="4.72968" /score="-7.82934513" /energy="-9.2" /TU="NA" /idTUdmin="U767" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 943867..943872 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(943872..943971) /Source="Nicolas_S_feature" /locus_tag="new_1041710_1041809_c" /HighExp="Cold, T3.0H, T2.30H, T3.30H, T4.0H, T2.0H, HPh, C30, T1.30H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S336" promotor_-10 943888..943906 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 943890 /Source="Nicolas_upshifts" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="upshifts" S_feature 943895..944090 /Source="Nicolas_S_feature" /locus_tag="new_1041733_1041928" /HighExp="S5, S4, S6, S3, S7, S8, LoTm, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S337" promotor_-10 complement(943960..943979) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(943974) /Source="Nicolas_upshifts" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(943994..943997) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 944089..944108 /Source="Nicolas_upshift_promotors" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 944092..944155 /Source="Nicolas_S_feature" /locus_tag="new_1041930_1041993" /HighExp="BC, T2.30H, T3.0H, T3.30H, T4.0H, T5.0H, T2.0H, T1.30H, S4, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S338" upshifts 944092 /Source="Nicolas_upshifts" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="upshifts" CDS 944156..945004 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /EC_number="2.6.1.21" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9003455, 17005988; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine aminotransferase" /protein_id="NP_388848.1" /db_xref="EnsemblGenomes-Gn:BSU09670" /db_xref="EnsemblGenomes-Tr:CAB12806" /db_xref="GOA:O07597" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005784" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG13045" /db_xref="UniProtKB/Swiss-Prot:O07597" /translation="MKVLVNGRLIGRSEASIDLEDRGYQFGDGIYEVIRVYKGVLFGL REHAERFFRSAAEIGISLPFSIEDLEWDLQKLVQENAVSEGAVYIQTTRGVAPRKHQY EAGLEPQTTAYTFTVKKPEQEQAYGVAAITDEDLRWLRCDIKSLNLLYNVMTKQRAYE AGAFEAILLRDGVVTEGTSSNVYAVINGTVRTHPANRLILNGITRMNILGLIEKNGIK LDETPVSEEELKQAEEIFISSTTAEIIPVVTLDGQSIGSGKPGPVTKQLQAAFQESIQ QAASIS*" /label="dat CDS" gene 944156..945004 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /label="dat gene" downshifts 944995 /Source="Nicolas_upshifts" /id="D511" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="2.27201" /MaxDrop="6.88888" /score="21.6239924" /energy="-11.5" /TU="U768" /idTUdmin="U766" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(945047..946408) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735849, 11274110, 15849754, 16850406, 17937670" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 11274110, 15849754, 16850406, 17937670; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_388849.1" /db_xref="EnsemblGenomes-Gn:BSU09680" /db_xref="EnsemblGenomes-Tr:CAB12807" /db_xref="GOA:O07553" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG13044" /db_xref="UniProtKB/Swiss-Prot:O07553" /translation="MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVM LSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALS FIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGA CFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAA STDNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFV PYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLIMIAFALGGLMEKIG LISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQ RKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGF VKK*" /label="nhaC CDS" gene complement(945047..946408) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /label="nhaC gene" downshifts complement(945071) /Source="Nicolas_upshifts" /id="D512" /incds=0 /nref=7 /ntot=77 /MaxReadThrough="0.50034" /MaxDrop="3.60175" /score="1.04025421" /energy="-11.5" /TU="NA" /idTUdmin="U769" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(946409..946479) /Source="Nicolas_S_feature" /locus_tag="new_1044247_1044317_c" /HighExp="B60, G135, Etha, LBGexp, G150, Diami, Paraq, G180, H2O2, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S339" misc_feature complement(946452..946471) /Source="Nicolas_upshift_promotors" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(946479) /Source="Nicolas_upshifts" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(946535..947035) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /function="16.12: Sense" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 16159758, 27464829; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein, UspA family" /protein_id="NP_388850.2" /db_xref="EnsemblGenomes-Gn:BSU09690" /db_xref="EnsemblGenomes-Tr:CAB12808" /db_xref="GOA:O07552" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13043" /db_xref="UniProtKB/Swiss-Prot:O07552" /translation="MFHADRIIVAFDGSENSKKALLTAIDLAKTVNAAITVAHSHDMK DNQTVIDPPRPAAEASYISGGMTSVPDPLISDVTSPEPMIYEDRTEEVIAEARMMLNE QQADGDIDILEGDPAESIIEHANRISADMIVTGSRDQNRLKKLIFGSVSEKLSAKSDI PVLIVK*" /label="nhaX CDS" gene complement(946535..947035) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /label="nhaX gene" downshifts complement(946567) /Source="Nicolas_upshifts" /id="D513" /incds=0 /nref=10 /ntot=63 /MaxReadThrough="4.74071" /MaxDrop="5.69273" /score="4.44189378" /energy="-12.2" /TU="U770" /idTUdmin="U770" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(947057..947075) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(947077) /Source="Nicolas_upshifts" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(947090..947096) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 947114..947121 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 947129..947198 /Source="Nicolas_S_feature" /locus_tag="new_1044967_1045036" /HighExp="C90, M9-stat, BC, T1.30H, T3.30H, Sw, T5.0H, GM 15, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S340" upshifts 947130 /Source="Nicolas_upshifts" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 947136..947155 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 947199..947360 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /experiment="publication(s) with functional evidences, PMID:25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25217586; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator leader peptide" /protein_id="NP_388851.1" /db_xref="EnsemblGenomes-Gn:BSU09700" /db_xref="EnsemblGenomes-Tr:CAB12809" /db_xref="SubtiList:BG13042" /db_xref="UniProtKB/Swiss-Prot:O07551" /translation="MFIKQFHIGAANLLFCFRERFFRSDRALKSAVRNISVKKGMELT LHAFFIYKI*" /label="bmrB CDS" gene 947199..947360 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /label="bmrB gene" downshifts 947290 /Source="Nicolas_upshifts" /id="D514" /incds=1 /nref=29 /ntot=180 /MaxReadThrough="5.31538" /MaxDrop="4.59672" /score="25.6910195" /energy="-14.4" /TU="U771" /idTUdmin="U768" /TUdmin=2273 /isTUend="FALSE" /label="downshifts" S_feature 947361..947479 /Source="Nicolas_S_feature" /locus_tag="new_1045199_1045317" /HighExp="LPhT, S7, S6, T-1.10H, Sw, LBGstat, S5, T-0.40H, S8, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S341" CDS 947480..949237 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388852.1" /db_xref="EnsemblGenomes-Gn:BSU09710" /db_xref="EnsemblGenomes-Tr:CAB12810" /db_xref="GOA:O07550" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13041" /db_xref="UniProtKB/Swiss-Prot:O07550" /translation="MFSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAI DDMKAGAFTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHLL TMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFLTMGFLISWK LTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRVLESVSGVRVIRAYVQET NDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKLLVGASYLIGLGYGAFLVFRNELTLG ELVSFNVYLGMMIWPMFAIGELINVMQRGNASLDRVNETLSYETDVTDPKQPADLKEP GDIVFSHVSFTYPSSTSDNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGE GSITFSGVPIQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAE AHFEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDDSLSAVDAK TEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAERGTHQELLANNGWY REQYERQQLFTAEEGGAGA*" /label="bmrC CDS" gene 947480..949237 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /label="bmrC gene" CDS 949234..951255 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding subunit)" /protein_id="NP_388853.1" /db_xref="EnsemblGenomes-Gn:BSU09720" /db_xref="EnsemblGenomes-Tr:CAB12811" /db_xref="GOA:O07549" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13040" /db_xref="UniProtKB/Swiss-Prot:O07549" /translation="MKIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMID DHILGIEKTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVDQ AVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVLLICLYGGLL VFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYFDNLPAGKVVARITNDTE AIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVKLAFVCLAIVPIIWLWSVIYRRYASY YNQKIRSINSDINAKMNESIQGMTIIQAFRHQKETMREFEELNESHFYFQNRMLNLNS LMSHNLVNVIRNLAFVCLIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQ FSKLELARVSAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHIS FTAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQELRSHMGI VLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKKLPKGINEPVIEKGST LSSGERQLISFARALAFDPAILILDEATAHIDTETEAVIQKALDVVKQGRTTFVIAHR LSTIRNADQILVLDKGEIVERGNHEELMALEGQYYQMYELQKGQKHSIA*" /label="bmrD CDS" gene 949234..951255 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /label="bmrD gene" downshifts 951243 /Source="Nicolas_upshifts" /id="D515" /incds=0 /nref=69 /ntot=230 /MaxReadThrough="0.741399999999999" /MaxDrop="5.11492" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U771" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(951304..951924) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-flavin oxidoreductase" /protein_id="NP_388854.1" /db_xref="EnsemblGenomes-Gn:BSU09730" /db_xref="EnsemblGenomes-Tr:CAB12812" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13039" /db_xref="UniProtKB/Swiss-Prot:O07548" /translation="MKIALLGASGRVGQAFLTQAAADERFDIFALIRSQHADLPLSKD RTVMGNARRLEDVKKIMENAEIVISCLGTDGDDTLSTAMAHILSVMEEQHIKRLITIG TAGILDSRYEPGKYRFETNESKRKQTRAAKEHAKVYEMLKESSLDWTIICPTYLPDGT ATGVYRTERNVLPEGGTSISVGDTADFLYRELVTGEYVGNRVGLAY*" /label="yheG CDS" gene complement(951304..951924) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /label="yheG gene" downshifts complement(951319) /Source="Nicolas_upshifts" /id="D516" /incds=0 /nref=19 /ntot=169 /MaxReadThrough="1.82652" /MaxDrop="3.00293" /score="-0.293143554" /energy="-10.9" /TU="NA" /idTUdmin="U772" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 951909..952009 /Source="Nicolas_upshift_promotors" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(951938..951957) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(951953) /Source="Nicolas_upshifts" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="upshifts" CDS complement(951963..952088) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388855.1" /db_xref="EnsemblGenomes-Gn:BSU09740" /db_xref="EnsemblGenomes-Tr:CAB12813" /db_xref="SubtiList:BG13038" /db_xref="UniProtKB/Swiss-Prot:O07547" /translation="MSFITIVNWELVQFVSVSMIHEYVSHRSVYLYRYSFPRCSN*" /label="yheF CDS" gene complement(951963..952088) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /label="yheF gene" upshifts 951969 /Source="Nicolas_upshifts" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(951972..951975) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(952102..952121) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(952111) /Source="Nicolas_upshifts" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(952135..952144) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 952167 /Source="Nicolas_upshifts" /id="D517" /incds=0 /nref=6 /ntot=22 /MaxReadThrough="0.352760000000001" /MaxDrop="4.67633" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U773" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(952193..952396) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:3009398, 9572981, 16707666, 19659696, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009398, 9572981, 16707666, 19659696, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (beta-type SASP)" /protein_id="NP_388856.1" /db_xref="EnsemblGenomes-Gn:BSU09750" /db_xref="EnsemblGenomes-Tr:CAB12814" /db_xref="GOA:P04832" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10787" /db_xref="UniProtKB/Swiss-Prot:P04832" /translation="MANQNSSNDLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRANG SVGGEITKRLVSFAQQQMGGRVQ*" /label="sspB CDS" gene complement(952193..952396) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /label="sspB gene" downshifts complement(952198) /Source="Nicolas_upshifts" /id="D518" /incds=0 /nref=72 /ntot=93 /MaxReadThrough="1.27819" /MaxDrop="8.55895" /score="22.2113888" /energy="-16" /TU="NA" /idTUdmin="U776" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(952397..952507) /Source="Nicolas_S_feature" /locus_tag="new_1050235_1050345_c" /HighExp="S8, S5, S7, S6, S4, G/S, Pyr, ferm, BT, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S342" promotor_no_box 952437..952537 /Source="Nicolas_upshift_promotors" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 952497 /Source="Nicolas_upshifts" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(952513) /Source="Nicolas_upshifts" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(952517..952528) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(952543..952549) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(952605..952823) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation / germination island)" /protein_id="NP_388857.1" /db_xref="EnsemblGenomes-Gn:BSU09760" /db_xref="EnsemblGenomes-Tr:CAB12815" /db_xref="InterPro:IPR017263" /db_xref="SubtiList:BG13037" /db_xref="UniProtKB/Swiss-Prot:O07546" /translation="MAVMISHFSWKPLFPKEKLPGWKISFYYKGTHYEGIYHKSGEIE WGDLFPARADEPALTNEIHELMLFHIYD*" /label="yheE CDS" gene complement(952605..952823) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /label="yheE gene" downshifts complement(952639) /Source="Nicolas_upshifts" /id="D519" /incds=0 /nref=5 /ntot=83 /MaxReadThrough="0.43384" /MaxDrop="3.42951" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U777" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(952864..952883) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(952881) /Source="Nicolas_upshifts" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(952897..952904) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(952973..954334) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /function="16.5: Explore" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15231775, 25035995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 25035995; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat associated protein" /protein_id="NP_388858.2" /db_xref="EnsemblGenomes-Gn:BSU09770" /db_xref="EnsemblGenomes-Tr:CAB12816" /db_xref="GOA:O07545" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13036" /db_xref="UniProtKB/Swiss-Prot:O07545" /translation="MNPKRFLIGIDKTSENTLFLPSSLKQDGLLHAAFGTKVVRCHVA YRRHLEQTVLLSENLFHELLLPHRSRADILIHDHTVHIGPLVGIFTAGFTVSLERPFK DRSLFFSKLVTLHEQAGGYCFVFGAHQINWEEGTIEGLLYRENGWEKKIVPLPNVVYD RLPNRKIEDSLLLQHTKKRLIDEYQIPWFNKTFFNKWNVHQLLEKDPRTAPFLPRSEL TPSVELIDELCGAYKKVYIKPANGALGTGIYQLTRTDGGLTVKHTNDAKTFTSIDYSD AASFLAEFQKHHNPSDFLIQQGVDLIEFQGKPADFRVHTNKNRKGKWTVTAIAVKISG KNSITTHLSNGGTVKTLAEVYDDPAERVEVIKKLSAAALTASHVLHDHIEGFIGEIGF DFGIDQNGKVWMFEANSRPGRSIFSHPNLHHVDSLTKRRSFEYASYLSEKAITSPEAL WPS*" /label="spaD CDS" gene complement(952973..954334) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /label="spaD gene" downshifts complement(952991) /Source="Nicolas_upshifts" /id="D520" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.33323" /MaxDrop="3.7968" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(953035) /Source="Nicolas_upshifts" /id="D521" /incds=1 /nref=2 /ntot=45 /MaxReadThrough="5.29177" /MaxDrop="3.36501" /score="37.4339943" /energy="-11.8" /TU="U779" /idTUdmin="U779" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(954324..955415) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231775, 25035995; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat associated protein, subunit C" /protein_id="NP_388859.1" /db_xref="EnsemblGenomes-Gn:BSU09780" /db_xref="EnsemblGenomes-Tr:CAB12817" /db_xref="GOA:O07544" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13035" /db_xref="UniProtKB/Swiss-Prot:O07544" /translation="MITLGFMSLSRQHEADYSAELAKRAPEFGIRFIRFTPFDISPDT LRVKASVYHSASSTWNETEMAIPDYIYDRCFYGKDSHSQKAKPIVEWLKKYPKTEFIG RGLPDKWTVLHDLQQHSVINPYIPETIKVSRYEQIHSFLSKEKACILKPAFGAGGRGV ILLKLGKKNITATYHIGKDKQTKTFSNQTSFKTWCKKVLQHQYLLQPYLNIQDKEQYP CDIRLFMEKNEAGEWNTVGKAVRRGYKHGLLANLSGGSDALTFDSWFEDIPKKQQVVL LDDVFSITQSVPYYLDERYGPLFELGLDICLAKDGRIWILDINSKPGRKSILRVSPEQ KEQLYTCPLKRCQYLFSEQSQKGVLPRES*" /label="spaC CDS" gene complement(954324..955415) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /label="spaC gene" promotor_-10 complement(954739..954753) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(954751) /Source="Nicolas_upshifts" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(954767..954775) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(955416..955521) /Source="Nicolas_S_feature" /locus_tag="new_1053254_1053359_c" /HighExp="S4, B36, S5, S6, S7, S8, B60, S3, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S343" promotor_-10 complement(955505..955523) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(955525) /Source="Nicolas_upshifts" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(955539..955544) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 955587..955594 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 955609..955628 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 955620 /Source="Nicolas_upshifts" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="upshifts" CDS 955682..956815 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16684363" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388860.1" /db_xref="EnsemblGenomes-Gn:BSU09790" /db_xref="EnsemblGenomes-Tr:CAB12818" /db_xref="GOA:O07543" /db_xref="InterPro:IPR007383" /db_xref="InterPro:IPR016991" /db_xref="SubtiList:BG13034" /db_xref="UniProtKB/Swiss-Prot:O07543" /translation="MGIAGTFIFMIVIGAAIGAVTNHLAIQMLFRPYKAYYLFGKRVP FTPGLIPRRRDELAKQMGLMVVNHLLTPEGIKKRLVSDAAKTQALRVGEQLIQKLSLS EVTVKEALEKAGMKRPEKAADAWISSWTDDKLHELFRQYGDQSLKELVPIEVQEKLEE KIPMISGYILSRSVRYFESDEGKIRLGNMIDDFLKERGMLGSMVQLFLGNSSLADRVL PELLKFLRNEETNKLLSDLLKNEWGKLREYTFNEADEKWNAKALIFSLKRRVLQAFST APFFNNTIGTLTVRYESELTQQMLPALLDKLLEGISSNLESVLKRLRLEEIVKEQVDQ FPVERLEEMVLSISKKEFKMITYLGGLLGGIIGAIQALFVILF*" /label="yheB CDS" gene 955682..956815 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /label="yheB gene" S_feature 956816..956907 /Source="Nicolas_S_feature" /locus_tag="new_1054654_1054745" /HighExp="S4, S5, S6, BT, S3, S7, dia15, B36, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S344" CDS 956908..957261 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388861.1" /db_xref="EnsemblGenomes-Gn:BSU09800" /db_xref="EnsemblGenomes-Tr:CAB12819" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="PDB:2OEE" /db_xref="SubtiList:BG13033" /db_xref="UniProtKB/Swiss-Prot:O07542" /translation="MAVNFYDVAYDLENALRGSEEFTRLKNLYDEVNADESAKRMFEN FRDVQLRLQQKQMAGEEITQEEVTQAQKTVALVQQHEKISQLMEAEQRMSMLIGELNK IIMKPLEELYGSVEG*" /label="yheA CDS" gene 956908..957261 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /label="yheA gene" downshifts 957249 /Source="Nicolas_upshifts" /id="D522" /incds=0 /nref=159 /ntot=259 /MaxReadThrough="1.55668" /MaxDrop="5.9901" /score="24.5275597" /energy="-12.3" /TU="NA" /idTUdmin="U780" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(957305..958378) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290, 22933559" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388862.1" /db_xref="EnsemblGenomes-Gn:BSU09810" /db_xref="EnsemblGenomes-Tr:CAB12820" /db_xref="GOA:O07541" /db_xref="InterPro:IPR011989" /db_xref="InterPro:IPR014825" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR021133" /db_xref="SubtiList:BG13002" /db_xref="UniProtKB/Swiss-Prot:O07541" /translation="MADLKEIYNEELISQLIHHVRSSYPDFNKNRFLDTLRLEDWPEL TLKERMRRVTVSLYETLPKQYVEALTILRDTAPHFKGLSGILFPDYVEQYGLAHWEES IKALESFTQYSTSEFAVRPFLLLDQEKMIAQLLAWSEHKNEHVRRLASEGSRPRLPWG KSIPALKSDPSPVLPILEKLMQDESLYVRKSVANNLNDISKTHPHLLRKVADQWYGTH PHTDWIIKHAYRTLLKKGDKQALALFGYENADSIQLHDLTCQPKRIVIGESLEFSFYI HSDRDQKVRIEYAIDFVKARGQRHQKVFKITETNIRKNETKSYTRIQSFKDLTTRKHY KGIHTLSVIINGEVKDSLDFQVC*" /label="yhaZ CDS" gene complement(957305..958378) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /label="yhaZ gene" downshifts complement(957412) /Source="Nicolas_upshifts" /id="D523" /incds=1 /nref=16 /ntot=173 /MaxReadThrough="3.78071" /MaxDrop="3.586" /score="4.43596345" /energy="-12.3" /TU="U781" /idTUdmin="U781" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(958400..958419) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(958412) /Source="Nicolas_upshifts" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(958433..958440) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 958515..958522 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 958535 /Source="Nicolas_upshifts" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 958537..958556 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 958546..958699 /Source="Nicolas_S_feature" /locus_tag="new_1056384_1056537" /HighExp="M9-stat, BC, T0.30H, T1.30H, Lbstat, T1.0H, T3.30H, T2.0H, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S345" downshifts 958656 /Source="Nicolas_upshifts" /id="D524" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="7.40404" /MaxDrop="2.6506" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 958701..958784 /Source="Nicolas_S_feature" /locus_tag="new_1056539_1056622" /HighExp="M9-stat, B60, T2.0H, T1.30H, T0.30H, T2.30H, T3.0H, T1.0H, Lbtran, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S346" downshifts 958741 /Source="Nicolas_upshifts" /id="D525" /incds=0 /nref=70 /ntot=231 /MaxReadThrough="4.88371" /MaxDrop="4.4099" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-971" /isTUend="FALSE" /label="downshifts" promotor_-35 958797..958802 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 958818..958836 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 958827 /Source="Nicolas_upshifts" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 958864..959730 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388864.2" /db_xref="EnsemblGenomes-Gn:BSU09830" /db_xref="EnsemblGenomes-Tr:CAB12822" /db_xref="GOA:O07539" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR036412" /db_xref="PDB:3DNP" /db_xref="SubtiList:BG13000" /db_xref="UniProtKB/Swiss-Prot:O07539" /translation="MSKQLLALNIDGALLRSNGKIHQATKDAIEYVKKKGIYVTLVTN RHFRSAQKIAKSLKLDAKLITHSGAYIAEKIDAPFFEKRISDDHTFNIVQVLESYQCN IRLLHEKYSIGNKKKVNSNLLGKALIHPSDPIFYPVQFVESLSDLLMDEPVSAPVIEV YTEHDIQHDITETITKAFPAVDVIRVNDEKLNIVPKGVSKEAGLALVASELGLSMDDV VAIGHQYDDLPMIELAGLGVAMGNAVPEIKRKADWVTRSNDEQGVAYMMKEYFRMQQR KGFLDKFHMKRV*" /label="yhaX CDS" gene 958864..959730 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /label="yhaX gene" downshifts 959712 /Source="Nicolas_upshifts" /id="D526" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="3.99904" /MaxDrop="4.7771" /score="15.7706912" /energy="-16.6" /TU="U783" /idTUdmin="U782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 959775..959778 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 959793..959812 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 959801 /Source="Nicolas_upshifts" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 959842..961347 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /EC_number="1.3.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10498703, 21255303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498703, 21255303; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_388865.1" /db_xref="EnsemblGenomes-Gn:BSU09840" /db_xref="EnsemblGenomes-Tr:CAB12823" /db_xref="GOA:Q796V8" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023995" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG12999" /db_xref="UniProtKB/Swiss-Prot:Q796V8" /translation="MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISL ALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTG ITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAA VPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEW LKEHDVKVTTIYFGGGTPTSITAEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITE EKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLI IGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMM EDAVAWTKEHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCG AASKFIDRDTGKITHFANPKDPKSYNERFEHYTDEKIKYLEQIFEKTTKQH*" /label="hemZ CDS" gene 959842..961347 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /label="hemZ gene" downshifts 961317 /Source="Nicolas_upshifts" /id="D527" /incds=0 /nref=113 /ntot=234 /MaxReadThrough="0.523269999999999" /MaxDrop="5.05369" /score="38.1573779" /energy="-14.4" /TU="NA" /idTUdmin="U783" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(961365..962582) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7934942, 14987767, 15849754, 15919996, 16850406, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934942, 14987767, 15849754, 15919996, 16850406, 24330391; Product type t : transporter" /codon_start=1 /transl_table=11 /product="proton/potassium antiporter; methylglyoxal resistance" /protein_id="NP_388866.2" /db_xref="EnsemblGenomes-Gn:BSU09850" /db_xref="EnsemblGenomes-Tr:CAB12825" /db_xref="GOA:O07536" /db_xref="InterPro:IPR006153" /db_xref="SubtiList:BG12997" /db_xref="UniProtKB/Swiss-Prot:O07536" /translation="MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHA PKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILI NFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMF EDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIR SNEVFIIVIFAALFFIAGFSETIHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFF GAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGRRAGLSHKASSNIGL TIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVF KWKPEVQPAKKQG*" /label="khtU CDS" gene complement(961365..962582) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /label="khtU gene" downshifts complement(961371) /Source="Nicolas_upshifts" /id="D528" /incds=0 /nref=154 /ntot=249 /MaxReadThrough="1.74386" /MaxDrop="6.8685" /score="8.64654688" /energy="-14.4" /TU="NA" /idTUdmin="U785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(962589..963086) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388867.1" /db_xref="EnsemblGenomes-Gn:BSU09860" /db_xref="EnsemblGenomes-Tr:CAB12826" /db_xref="GOA:O07535" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG12996" /db_xref="UniProtKB/Swiss-Prot:O07535" /translation="MNIKENDLPGIGKKFEIETRSHEKMTIIIHDDGRREIYRFNDRD PDELLSNISLDDSEARQIAAILGGMVYKPQALESIEMAFSDLIIEWFKVEKGAKSIGR TLGELDVRQNYDVTVIAIIKHNQEKLLNPGADSIIEENDTLVLSGERKHLKKLIHDFL SGEGV*" /label="khtT CDS" gene complement(962589..963086) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /label="khtT gene" CDS complement(963150..963488) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388868.1" /db_xref="EnsemblGenomes-Gn:BSU09870" /db_xref="EnsemblGenomes-Tr:CAB12827" /db_xref="GOA:O07534" /db_xref="SubtiList:BG12995" /db_xref="UniProtKB/Swiss-Prot:O07534" /translation="MRREERNMDKLLISFLLSLFMVYFPPSDVVLPSQFEASTDSYVP MSSYPQETQSAKTPSPGSMHPAELIKEYSPLAQSVRQLSVKPLDEPLINRLEKALAVP VKYQSNYLRI*" /label="khtS CDS" gene complement(963150..963488) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /label="khtS gene" promotor_-10 complement(963500..963519) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(963524) /Source="Nicolas_upshifts" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(963533..963540) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 963560..963567 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 963582..963601 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 963592 /Source="Nicolas_upshifts" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="upshifts" CDS 963653..964420 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22961985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase / isomerase" /protein_id="NP_388869.3" /db_xref="EnsemblGenomes-Gn:BSU09880" /db_xref="EnsemblGenomes-Tr:CAB12828" /db_xref="GOA:O07533" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12994" /db_xref="UniProtKB/Swiss-Prot:O07533" /translation="MEFVQYACNGAVAEIILNRPDAHHALNEQMLSELKEAVEMAAAS EALIVLLRGSGKGFSAGGDIRMMTSEHDPDQFKRLMDTIEAVTLNLYQMKKVTIAAIH GAAAGLGLSLALCADIVLAEKNAVLAMNFIGIGLVPDGGGHYLLKKRIGEAKAKKLIW SGKKLSASEAADMGLLDGTFAGDPAEGARPIIETLLASPLLAMIETKGIFQSLQIEEL KKVLSLERSAQERMRRTKDHQEGIRAFLEKREPKFQA*" /label="yhaR CDS" gene 963653..964420 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /label="yhaR gene" downshifts 964421 /Source="Nicolas_upshifts" /id="D529" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="1.78111" /MaxDrop="4.66019" /score="-8.79921781" /energy="-7.5" /TU="NA" /idTUdmin="U786" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(964441..964626) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097698.1" /db_xref="EnsemblGenomes-Gn:BSU09889" /db_xref="EnsemblGenomes-Tr:CAX52586" /db_xref="InterPro:IPR025544" /db_xref="UniProtKB/Swiss-Prot:C0H3Y1" /translation="MADYFLTVFDPSGNTLVNEQFEAEHEEAAKTHGEALLKEKELHS HTHRLVNAAGKLILFHR*" /label="yhzD CDS" gene complement(964441..964626) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /label="yhzD gene" promotor_-10 complement(964662..964680) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(964673) /Source="Nicolas_upshifts" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(964691..964699) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 964700..964703 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 964718..964737 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 964728 /Source="Nicolas_upshifts" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="upshifts" CDS 964753..965649 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 12374817; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388870.2" /db_xref="EnsemblGenomes-Gn:BSU09890" /db_xref="EnsemblGenomes-Tr:CAB12829" /db_xref="GOA:C0SPB4" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12993" /db_xref="UniProtKB/Swiss-Prot:C0SPB4" /translation="MLTIDHVTKTFGDYKAVDGLDLDIPEQQMFGLLGANGAGKTTTF RMILGLLSITEGSISWKGRPVNYHISNKIGYLPEERGLYPKMKVRDQLVYLARLKGME KREAVKELGTWLERFNITDYENKKVEELSKGNQQKIQFISAVLHKPELLILDEPFSGL DPVNVELLKEAVISLKNSGVSILFSSHRMEHVEELCENLCILQKGKPVVQGKLKEIKR SFGKKNVTIHSDDDLRFLQSHEGILQWKETADGVKLQIANEDISQEIFAMLQGKGFIR KFELEEPSLHDIFIEKVGAVYE*" /label="yhaQ CDS" gene 964753..965649 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /label="yhaQ gene" CDS 965642..966901 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent exporter (ABC permease)" /protein_id="NP_388871.2" /db_xref="EnsemblGenomes-Gn:BSU09900" /db_xref="EnsemblGenomes-Tr:CAB12830" /db_xref="GOA:O07523" /db_xref="SubtiList:BG12992" /db_xref="UniProtKB/Swiss-Prot:O07523" /translation="MNKFWIMLSHTYKNKIMAKSFIISTVITVLLVLVVTNLESIISL FQGDDAKEKIAVVDETNELYPVFSKQLKAVDTDGDLDVKLSKQSEDEVTKQVKDESLD GMLIIKRDEKGTISGTYKALTISDESTYQTLQQALTQTKTAVGTAELGVSQETISSLY APVTVGQKALKEGAKSEEELGQTVGLVYIMLFVIYFSVIMYASMIAMEVATEKSSRVM EILISSMPPIQQMFAKLLGIGLVGITQLAIIIGAGSLSLKLNQKSETASSVGGFLNLT DVSATTVIYAVIFFLLGYFLYATLAAFLGSVVSRIEDVQQTITPMTLLVVAGFMIAMF GLNAPDAGFITVTSFIPFFTPMIMFLRVGMLDIPFWQAAVGIGITLLTIVILAVIGAR IYKGGVLIYGNSSAFKAIKQALRLAKN*" /label="yhaP CDS" gene 965642..966901 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /label="yhaP gene" downshifts 966885 /Source="Nicolas_upshifts" /id="D530" /incds=0 /nref=19 /ntot=187 /MaxReadThrough="2.50232" /MaxDrop="3.26822" /score="8.93460501" /energy="-12.8" /TU="NA" /idTUdmin="U788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 966949..966956 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 966968..966987 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 966973 /Source="Nicolas_upshifts" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 967008..968234 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA repair exonuclease" /protein_id="NP_388872.1" /db_xref="EnsemblGenomes-Gn:BSU09910" /db_xref="EnsemblGenomes-Tr:CAB12831" /db_xref="GOA:O07522" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR014576" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12991" /db_xref="UniProtKB/Swiss-Prot:O07522" /translation="MLTDLTFIHAADLHLDSPFYGISHLPEPIFARIKESTFASVRHM IDAAVREHVDFILLAGDLFDEANRSLKAQLFLKKQFERLRECGISVYVIFGNHDHLGG EWTPIEWPENVHIFSSAVPEEKSFFKEGRRIASIYGFSYQARALMENQAARYRRSTDA PFHIGMLHGTLSGSEGHDPYCPFTHDDLVKSGMDYWALGHIHKRQVLSAEHPAVIYPG NTQARHIKETGDKGYYLVHVTNGDISYEFQRAHDVLWEKAAVDVTEAKNMTALFQMVE DTFSKLRKKGSPVCVRLVLQGTAPEWLLEAPKGTLDEFLEALQEQEAEEERFVWPLRL DDETENEANLTNLDPFFGGLFEDIDRSDLSDVLEGLERHPVYRRHADRFSQEEVKEIK EQAQIILKRQLKVLDT*" /label="yhaO CDS" gene 967008..968234 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /label="yhaO gene" downshifts complement(967709) /Source="Nicolas_upshifts" /id="D531" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="0.0165100000000002" /MaxDrop="3.62411" /score="-5.83060322" /energy="-15.2" /TU="NA" /idTUdmin="U787" /TUdmin="-3300" /isTUend="FALSE" /label="downshifts" CDS 968239..971130 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16267290, 19906728, 21517913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267290, 19906728, 21517913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATPase involved in DNA double strand break repair and recombination" /protein_id="NP_388873.1" /db_xref="EnsemblGenomes-Gn:BSU09920" /db_xref="EnsemblGenomes-Tr:CAB12832" /db_xref="GOA:O08455" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12990" /db_xref="UniProtKB/Swiss-Prot:O08455" /translation="MTALRIISLHIYQYGKFSNRTFDFSASPVQVIYGLNEAGKTTMM SFIESMLFGFPKTKKYEPKTGGVYGGVLEAEHPEYGVLKIERTKGTAEKLSVYTEKGE VKQGDVLKQLFQGTDRSLYKAIYSFDVFGLQEIHAFNRDKIGEFLLFSSLFGAEAVSK LDSRLTKESERLYKPNGRNPQLNQELETLKQLAVKLKQAEAEEAGYHQLLEEKRTLEA RLAAAETELKETAGHIRMIEGAIERKPLLNEKATLEQVIAEFPEHAGQFPADGLHQLE KYESHLHPKSAQLEALRVKMAELDKQRQKLIPDKELLAKETLIQELSAAFHMYQSWGE QLAAIQAQLRQTSAQTAAGLEQLNKTDENELLNMNTSYDYEWQLQQAVQQYVQARDRK RQLDETFELARQELEDAEKAVRAASSAILENSQRKDKEAALRAYDETQGQHQEQAKLR EQLTFFERQQAKQKKTVIAAGMLFIVLFSLLQQWIPAISFGAALIVYWLVSGKSSSRN SRETRQPMTDISPAEAEMLREALWEDDRNKQHLLTQRAALQQKEAAYERVIQQFEQWE AEMAPSFTQVERFMNELGFKEDPSFLLDAYSLMKDVKKEVKKKHELTIEAGRLKKHRR TFEERVSMLLPVNQSQDISISDALHTLRKNIEREKEIEKQKKEIETDIHYTKEQMLEL EQEIQYFHAQIEQLFAAAAAKDRDAFFAIAAISRQLKDTENKLHHVNAQLQGGYPEEL ELADSNTLSELKDKQFVENERKERLTEEIEQLRSQIALLSVKQEQLEASGMVSDLKLQ TEMQKERVKETAKKWASIQMVKQVIRNKLERHKKIELPRLLETAGEFFRPLTDGNYQT IYFSETDDSIMVMHRDGTVYHAEELSQGTCEQLYTAIRFALAVTRQGESKLPFQLDDS FVHFDQERLKRVLHVLYDLSEGGRQILYFTCHEHVKDAFHSSQIIHLVS*" /label="sbcE CDS" gene 968239..971130 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /label="sbcE gene" promotor_-35 969520..969525 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 969541..969559 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 969547 /Source="Nicolas_upshifts" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 971138..971143 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 971158..971177 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 971173 /Source="Nicolas_upshifts" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 971204..972148 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 16267290, 19553197, 19880604" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 16267290, 19553197, 19880604; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3'-5' exonuclease" /protein_id="NP_388874.1" /db_xref="EnsemblGenomes-Gn:BSU09930" /db_xref="EnsemblGenomes-Tr:CAB12833" /db_xref="GOA:O07521" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020873" /db_xref="SubtiList:BG12989" /db_xref="UniProtKB/Swiss-Prot:O07521" /translation="MAKGIMLHEVGEQVDQYLLIKSSTKGIASNGKPFLTLMLQDQSG DIEAKLWDAKQSDEVTYAPQTIVKVVGDVHHYRGRTQLKLRNIRPVSEQENVNIDDFL ETAPIPKNEMMDTITQYIFEMKNPNIQRITRFLVKKHEAEFMDYPAATKNHHEFVSGL AYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGH ISIMVTELSKAAEELQIDSEEVLILQHLILSHHGKAEWGSPKPPMVKEAEILHYIDNL DAKMNMMDRALERVKPGEYTERVFALENRSFYKPTFHK*" /label="yhaM CDS" gene 971204..972148 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /label="yhaM gene" downshifts 972126 /Source="Nicolas_upshifts" /id="D532" /incds=0 /nref=183 /ntot=261 /MaxReadThrough="3.02818" /MaxDrop="5.88173" /score="6.06919899" /energy="-15.8" /TU="NA" /idTUdmin="U789" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 972207..972212 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 972228..972246 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 972231 /Source="Nicolas_upshifts" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="upshifts" CDS 972273..972485 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523133; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="sporulation factor" /protein_id="NP_388875.1" /db_xref="EnsemblGenomes-Gn:BSU09940" /db_xref="EnsemblGenomes-Tr:CAB12834" /db_xref="GOA:O07520" /db_xref="InterPro:IPR025428" /db_xref="SubtiList:BG12988" /db_xref="UniProtKB/Swiss-Prot:O07520" /translation="MLFFPWWVYLCIVGIIFSAYKLVAAAKEEEKVDQAFIEKEGQIY MERMEKERERRSSQQHEEENQNHSIA*" /label="yhaL CDS" gene 972273..972485 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /label="yhaL gene" downshifts 972478 /Source="Nicolas_upshifts" /id="D533" /incds=0 /nref=8 /ntot=158 /MaxReadThrough="2.03283" /MaxDrop="6.60832" /score="62.1892984" /energy="-22" /TU="NA" /idTUdmin="U792" /TUdmin=5 /isTUend="TRUE" /label="downshifts" downshifts complement(972516) /Source="Nicolas_upshifts" /id="D534" /incds=0 /nref=97 /ntot=260 /MaxReadThrough="0.90997" /MaxDrop="9.00938" /score="52.3375501" /energy="-22" /TU="NA" /idTUdmin="U793" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(972526..973404) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12634326, 12682299, 14976191, 16516208, 25525259, 26711778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12634326, 12682299, 14976191, 16516208, 25525259, 26711778; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molecular chaperone lipoprotein" /protein_id="NP_388876.1" /db_xref="EnsemblGenomes-Gn:BSU09950" /db_xref="EnsemblGenomes-Tr:CAB12835" /db_xref="GOA:P24327" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR023059" /db_xref="InterPro:IPR027304" /db_xref="PDB:1ZK6" /db_xref="PDB:4WO7" /db_xref="SubtiList:BG10464" /db_xref="UniProtKB/Swiss-Prot:P24327" /translation="MKKIAIAAITATSILALSACSSGDKEVIAKTDAGDVTKGELYTN MKKTAGASVLTQLVQEKVLDKKYKVSDKEIDNKLKEYKTQLGDQYTALEKQYGKDYLK EQVKYELLTQKAAKDNIKVTDADIKEYWEGLKGKIRASHILVADKKTAEEVEKKLKKG EKFEDLAKEYSTDSSASKGGDLGWFAKEGQMDETFSKAAFKLKTGEVSDPVKTQYGYH IIKKTEERGKYDDMKKELKSEVLEQKLNDNAAVQEAVQKVMKKADIEVKDKDLKDTFN TSSTSNSTSSSSSNSK*" /label="prsA CDS" gene complement(972526..973404) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /label="prsA gene" downshifts complement(972714) /Source="Nicolas_upshifts" /id="D535" /incds=1 /nref=10 /ntot=127 /MaxReadThrough="7.54458" /MaxDrop="3.5906" /score="52.3375501" /energy="-22" /TU="U793" /idTUdmin="U793" /TUdmin="-187" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(973442..973461) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(973466) /Source="Nicolas_upshifts" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(973475..973482) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 973502..973511 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 973523 /Source="Nicolas_upshifts" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 973524..973543 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(973560..973574) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(973561) /Source="Nicolas_upshifts" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 973564..973650 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:20156992, 21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20156992, 21670523; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="spore assembly and germination protein" /protein_id="YP_003097699.1" /db_xref="EnsemblGenomes-Gn:BSU09958" /db_xref="EnsemblGenomes-Tr:CAX52587" /db_xref="GOA:C0H3Y2" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y2" /translation="MSGGYSNGFALLVVLFILLIIVGAAYIY*" /label="sscA CDS" gene 973564..973650 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /label="sscA gene" promotor_-35 complement(973583..973587) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 973651..973902 /Source="Nicolas_S_feature" /locus_tag="new_1071489_1071740" /HighExp="S8, S7, S6, BT, G/S, B36, Pyr, S5, B60, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S347" CDS 973775..973861 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore and germination protein" /protein_id="YP_009513948.1" /db_xref="EnsemblGenomes-Gn:BSU09959" /db_xref="EnsemblGenomes-Tr:CCQ48595" /db_xref="GOA:L8EBJ6" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8EBJ6" /translation="MGEVFAGGFALLVVLFILLIIIGASWLY*" /label="sscB CDS" gene 973775..973861 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /label="sscB gene" downshifts 973859 /Source="Nicolas_upshifts" /id="D536" /incds=0 /nref=28 /ntot=50 /MaxReadThrough="4.67734" /MaxDrop="4.7906" /score="14.3797211" /energy="-17.6" /TU="U794" /idTUdmin="U794" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" S_feature complement(973871..974133) /Source="Nicolas_S_feature" /locus_tag="new_1071709_1071971_c" /HighExp="LBGtran, LBGstat, LPhT, LBGexp, HPh, dia15, T0.30H, dia0, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S348" S_feature 973904..974387 /Source="Nicolas_S_feature" /locus_tag="new_1071742_1072225" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, Glucon, G/S, C90" /AntisenseName="yhaJ" /AntisenseCor="-0.22462434208606599" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S349" downshifts complement(973914) /Source="Nicolas_upshifts" /id="D537" /incds=0 /nref=153 /ntot=265 /MaxReadThrough="1.32339" /MaxDrop="6.55635" /score="34.7913848" /energy="-17.6" /TU="NA" /idTUdmin="U796" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(974126..974145) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(974133) /Source="Nicolas_upshifts" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(974135..974203) /Source="Nicolas_S_feature" /locus_tag="new_1071973_1072041_c" /HighExp="Paraq, G180, C30, LBGexp, Oxctl, G135, Lbexp, Heat, G150, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29568499999999998" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S350" promotor_-35 complement(974159..974164) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(974204..974722) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009, 21670523, 25651892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme" /protein_id="NP_388878.2" /db_xref="EnsemblGenomes-Gn:BSU09965" /db_xref="EnsemblGenomes-Tr:CAB12837" /db_xref="GOA:O07518" /db_xref="InterPro:IPR021683" /db_xref="SubtiList:BG12986" /db_xref="UniProtKB/Swiss-Prot:O07518" /translation="MNCWKTINLMKDYGAVRIILTAVCFMILVFISTFLAFELLRPGT SLSDEYVSLFGGLLVVILFVHKVIHVLPIICKKRKIEKKFYILRMRTWKRIPKTTMLI SLVSPFLLITPVLFYAALAFPNHAHYFCMISGIHAGYCLPDFLLALKLIKAPKTAFID QEADGLDILVEK*" /label="yhaJ CDS" gene complement(974204..974722) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /label="yhaJ gene" promotor_-35 974509..974517 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 974529..974547 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 974542 /Source="Nicolas_upshifts" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(974753..974772) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(974771) /Source="Nicolas_upshifts" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(974788..974794) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 974871..974874 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 974889..974908 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 974894 /Source="Nicolas_upshifts" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="upshifts" CDS 974930..975271 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388879.1" /db_xref="EnsemblGenomes-Gn:BSU09980" /db_xref="EnsemblGenomes-Tr:CAB12838" /db_xref="InterPro:IPR015058" /db_xref="InterPro:IPR035945" /db_xref="PDB:1SED" /db_xref="SubtiList:BG12985" /db_xref="UniProtKB/Swiss-Prot:O07517" /translation="MDSMDHRIERLEYYIQLLVKTVDMDRYPFYALLIDKGLSKEEGE AVMRICDELSEELATQKAQGFVTFDKLLALFAGQLNEKLDVHETIFALYEQGLYQELM EVFIDIMKHFD*" /label="yhaI CDS" gene 974930..975271 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /label="yhaI gene" S_feature complement(975125..975267) /Source="Nicolas_S_feature" /locus_tag="new_1072963_1073105_c" /HighExp="BC, S1, Sw, S2, S3, S8, S5, S4, S6, S7" /AntisenseName="yhaI" /AntisenseCor="5.4889858269512502E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S351" downshifts complement(975168) /Source="Nicolas_upshifts" /id="D538" /incds=1 /nref=39 /ntot=209 /MaxReadThrough="2.89899" /MaxDrop="4.77791" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(975268..975879) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of extracellular protease production, sporulation and bacilysin production (MarR family)" /protein_id="NP_388880.1" /db_xref="EnsemblGenomes-Gn:BSU09990" /db_xref="EnsemblGenomes-Tr:CAB12839" /db_xref="GOA:P11065" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR023488" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FXA" /db_xref="SubtiList:BG10659" /db_xref="UniProtKB/Swiss-Prot:P11065" /translation="MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDL NINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNFSKKLEERGYLRFSKRLNDKRNT YVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDF MEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS*" /label="scoC CDS" gene complement(975268..975879) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /label="scoC gene" S_feature 975272..976037 /Source="Nicolas_S_feature" /locus_tag="new_1073110_1073875" /HighExp="Lbstat, Etha, T0.30H, Gly, M0t90, M40t90, M40t45, M0t45, H2O2, dia15" /AntisenseName="scoC" /AntisenseCor="-0.46322626361720198" /AntisenseRegPval="-15" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S352" downshifts complement(975344) /Source="Nicolas_upshifts" /id="D539" /incds=1 /nref=1 /ntot=81 /MaxReadThrough="5.81117" /MaxDrop="2.1632" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" promotor_-35 975875..975879 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 975887..975900 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 975899 /Source="Nicolas_upshifts" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(975904..975923) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-10" upshifts complement(975927) /Source="Nicolas_upshifts" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="upshifts" promotor_-35 complement(975938..975941) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-35" downshifts 975994 /Source="Nicolas_upshifts" /id="D540" /incds=0 /nref=1 /ntot=124 /MaxReadThrough="3.007" /MaxDrop="2.86547" /score="17.8486533" /energy="-7.1" /TU="U799,U800" /idTUdmin="U799" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(976057..976413) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11429463; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein; acid tolerance protein" /protein_id="NP_388881.1" /db_xref="EnsemblGenomes-Gn:BSU10000" /db_xref="EnsemblGenomes-Tr:CAB12840" /db_xref="GOA:O07516" /db_xref="InterPro:IPR024623" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12984" /db_xref="UniProtKB/Swiss-Prot:O07516" /translation="MASGRSLLTGLFVGGIIGGAAVLLTAPSSGKQLREKMKTNYDSF EETIKRLKSDGLALKDQLIKAAKESTDVIKDVGGELQTSIKKWQEEIKPHQQDLQKEI ADIEEKIRQLEKTLQN*" /label="yhaH CDS" gene complement(976057..976413) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /label="yhaH gene" downshifts complement(976061) /Source="Nicolas_upshifts" /id="D541" /incds=0 /nref=254 /ntot=287 /MaxReadThrough="1.65317" /MaxDrop="7.37381" /score="10.8990112" /energy="-7.9" /TU="NA" /idTUdmin="U804" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 976490..976495 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(976496..976515) /Source="Nicolas_upshift_promotors" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(976510) /Source="Nicolas_upshifts" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 976511..976529 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 976511 /Source="Nicolas_upshifts" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(976512..976775) /Source="Nicolas_S_feature" /locus_tag="new_1074350_1074613_c" /HighExp="Etha, Salt, HiTm, Heat, Diami, Sw, Gly, S1, MG 10, MG 60" /AntisenseName="yhzF" /AntisenseCor="-0.69425315975357205" /AntisenseRegPval="-39.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S353" CDS 976543..976734 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="membrane protein of unknown function" /protein_id="YP_003097700.1" /db_xref="EnsemblGenomes-Gn:BSU10009" /db_xref="EnsemblGenomes-Tr:CAX52588" /db_xref="GOA:C0H3Y3" /db_xref="UniProtKB/Swiss-Prot:C0H3Y3" /translation="MSVFLIVLSCITLAFASGAVYYIKLLSQAASYPPKRVIRQKALV CSTGTAFTLCLIFFTKLLA*" /label="yhzF CDS" gene 976543..976734 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /label="yhzF gene" S_feature 976735..978170 /Source="Nicolas_S_feature" /locus_tag="new_1074573_1076008" /HighExp="S3, S8, S4, S6, S7, T5.0H, C30, S5, T4.0H, T3.30H" /AntisenseName="trpP" /AntisenseCor="-0.20038256384636899" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S354" CDS complement(976808..977326) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735881, 14702295, 15849754, 16850406, 16879415, 17114263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735881, 14702295, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="tryptophan transporter or sensor" /protein_id="NP_388882.2" /db_xref="EnsemblGenomes-Gn:BSU10010" /db_xref="EnsemblGenomes-Tr:CAB12841" /db_xref="GOA:O07515" /db_xref="InterPro:IPR031360" /db_xref="SubtiList:BG12983" /db_xref="UniProtKB/Swiss-Prot:O07515" /translation="MKTKELVIMALFAAIGAALHSIIPPFLGGMKPDMMLIMMFMGIL LFPRVQNVLVIGIVTGIISALTTAFPAGQIPNIIDKPVSAFLFFSLFLLFRKSRKTGA AAVLTVIGTILSGIVFLSSALLIVGLPGGFAALFAAVVLPAAVLNTISMIIIYPIVQT ILRRSSFMEAAK*" /label="trpP CDS" gene complement(976808..977326) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /label="trpP gene" downshifts complement(976820) /Source="Nicolas_upshifts" /id="D542" /incds=0 /nref=105 /ntot=253 /MaxReadThrough="6.00956" /MaxDrop="4.62812" /score="24.5949542" /energy="-12.8" /TU="U804,U805,U806" /idTUdmin="U804" /TUdmin="-750" /isTUend="FALSE" /label="downshifts" S_feature complement(977327..977414) /Source="Nicolas_S_feature" /locus_tag="new_1075165_1075252_c" /HighExp="C90, B60, S1, GM 15, MG 45, MG-0.2, Etha, Lbtran, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S355" promotor_-10 complement(977406..977425) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(977414) /Source="Nicolas_upshifts" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(977439..977446) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(977451..978530) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /EC_number="2.6.1.52" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4337849, 16233211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4337849, 16233211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine aminotransferase" /protein_id="NP_388883.1" /db_xref="EnsemblGenomes-Gn:BSU10020" /db_xref="EnsemblGenomes-Tr:CAB12842" /db_xref="GOA:P80862" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR022278" /db_xref="SubtiList:BG12673" /db_xref="UniProtKB/Swiss-Prot:P80862" /translation="MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSK EYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQFSMLPMNFLTPEKTAHFVMTGAW SEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEF PNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANV PKILKYSTHVKADSLYNTPPTFAIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCI DESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMIGLGGHRSVGGCRAS IYNAVSLEDCEKLAAFMKKFQQENE*" /label="serC CDS" gene complement(977451..978530) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /label="serC gene" misc_feature complement(978569..978588) /Source="Nicolas_upshift_promotors" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(978580) /Source="Nicolas_upshifts" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(978582..978663) /Source="Nicolas_S_feature" /locus_tag="new_1076420_1076501_c" /HighExp="Etha, dia15, H2O2, LBGtran, G135, G180, dia5, G150, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S356" CDS complement(978677..979114) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /EC_number="3.6.1.29" /EC_number="3.6.1.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579061, 15703176, 16934294, 17217311, 26181368, 28516732; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous Hit-family phosphohydrolase, adenosine phosphoramidase" /protein_id="NP_388884.1" /db_xref="EnsemblGenomes-Gn:BSU10030" /db_xref="EnsemblGenomes-Tr:CAB12843" /db_xref="GOA:O07513" /db_xref="InterPro:IPR001310" /db_xref="InterPro:IPR011146" /db_xref="InterPro:IPR019808" /db_xref="InterPro:IPR036265" /db_xref="PDB:1Y23" /db_xref="SubtiList:BG12607" /db_xref="UniProtKB/Swiss-Prot:O07513" /translation="MHCAENCIFCKIIAGDIPSAKVYEDEHVLAFLDISQVTKGHTLV IPKTHIENVYEFTDELAKQYFHAVPKIARAIRDEFEPIGLNTLNNNGEKAGQSVFHYH MHIIPRYGKGDGFGAVWKTHADDYKPEDLQNISSSIAKRLASS*" /label="hinT CDS" gene complement(978677..979114) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /label="hinT gene" downshifts complement(978708) /Source="Nicolas_upshifts" /id="D543" /incds=0 /nref=187 /ntot=248 /MaxReadThrough="4.31506" /MaxDrop="5.61862" /score="-0.366845751" /energy="-8.6" /TU="U806" /idTUdmin="U807" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(979147..979166) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(979161) /Source="Nicolas_upshifts" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" downshifts 979164 /Source="Nicolas_upshifts" /id="D544" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.3752" /MaxDrop="3.02008" /score="-3.56654132" /energy="-13.3" /TU="NA" /idTUdmin="U803" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(979180..979187) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(979186..979482) /Source="Nicolas_S_feature" /locus_tag="new_1077024_1077320_c" /HighExp="S7, S8, S6, S5, BT, ferm, nit, G/S, S4, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S357" downshifts complement(979229) /Source="Nicolas_upshifts" /id="D545" /incds=0 /nref=40 /ntot=72 /MaxReadThrough="3.07347" /MaxDrop="7.69075" /score="9.88617558" /energy="-14.2" /TU="U807" /idTUdmin="U807" /TUdmin="-517" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(979480..979491) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(979486) /Source="Nicolas_upshifts" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(979506..979512) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 979542..979549 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 979563..979582 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 979572 /Source="Nicolas_upshifts" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="upshifts" CDS 979602..980345 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 11807061, 18599827, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 11807061, 18599827, 26735940; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein)" /protein_id="NP_388885.1" /db_xref="EnsemblGenomes-Gn:BSU10040" /db_xref="EnsemblGenomes-Tr:CAB12844" /db_xref="GOA:P55339" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11516" /db_xref="UniProtKB/Swiss-Prot:P55339" /translation="MSLLSVKDLTGGYTRNPVLKNVSFTLEPNQIVGLIGLNGAGKST TIRHIIGLMDPHKGSIELNGKTFAEDPEGYRSQFTYIPETPVLYEELTLMEHLELTAM AYGLSKETMEKRLPPLLKEFRMEKRLKWFPAHFSKGMKQKVMIMCAFLAEPALYIIDE PFLGLDPLAINALLERMNEAKKGGASVLMSTHILATAERYCDSFIILHNGEVRARGTL SELREQFGMKDAALDDLYLELTKEDAGHE*" /label="ecsA CDS" gene 979602..980345 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /label="ecsA gene" CDS 980338..981564 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease subunit)" /protein_id="NP_388886.1" /db_xref="EnsemblGenomes-Gn:BSU10050" /db_xref="EnsemblGenomes-Tr:CAB12845" /db_xref="GOA:P55340" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG11517" /db_xref="UniProtKB/Swiss-Prot:P55340" /translation="MNNMLDIWQSRLQEHIKETRTYMKYMLNDHLVIVLIFFLAGAAS WYSKWIRDIPAHFPSFWVMAVLFSLVLTSSYVRTLLKEADLVFLLPLEAKMEPYLKQA FVYSYVSQLFPLIALSIVAMPLYFAVTPGASLVSYAAVFVQLLLLKAWNQVMEWRTTF QNDRSMKRMDVIIRFAANTLVLYFVFQSVYMYALLVYVIMAVLYLYMSSAAKRKTFKW ESHIESELRRKQRFYRIANLFTDVPHLRKQAKRRAYLDFLLRLVPFEQRKTFAYMFTR AFLRSSDYLGILVRLTIVFALIIMYVSASPLIAAVLTVFAIFITGIQLLPLFGHFDHL ALQELYPVQKETKLKSYFSLLKTALSIQALLMSVASAYAAGLTGFLYALIGSAVLIFV VLPAYMTTRLKKHGKL*" /label="ecsB CDS" gene 980338..981564 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /label="ecsB gene" promotor_-10 complement(980897..980915) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(980912) /Source="Nicolas_upshifts" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(980931..980936) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 981584..982294 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8581172, 10027970; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388887.1" /db_xref="EnsemblGenomes-Gn:BSU10060" /db_xref="EnsemblGenomes-Tr:CAB12846" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG11518" /db_xref="UniProtKB/Swiss-Prot:P55341" /translation="MTDNQLLMQEALEWKMHFLRKDSMFERFSKRVQTKVNERIPEKI HTVVTESVKKMVEATMAGSNIITYKKDTSALSLSEKNELAKKTIVSYQKVAAAEGVGT GAGGIFLSIADFPLLLSIKMKCLFTLSSIYGFDVKDAQERIFLLLVFQLAFSSDDGRK SLFSVIENWETEKKSIDWRVFQQEYRDYIDVVKLFQLLPGVGAAVGGIANYKLLAQLG ETARHVFHLRILKETAGE*" /label="ecsC CDS" gene 981584..982294 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /label="ecsC gene" downshifts 982258 /Source="Nicolas_upshifts" /id="D546" /incds=0 /nref=78 /ntot=231 /MaxReadThrough="1.36097" /MaxDrop="4.78417" /score="28.5337351" /energy="-14.6" /TU="NA" /idTUdmin="U808" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(982312..983502) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /EC_number="3.5.1.-" /experiment="publication(s) with functional evidences, PMID:23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl amino acid acetylase, promiscuous activity" /protein_id="NP_388888.2" /db_xref="EnsemblGenomes-Gn:BSU10070" /db_xref="EnsemblGenomes-Tr:CAB12847" /db_xref="GOA:O07598" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12982" /db_xref="UniProtKB/Swiss-Prot:O07598" /translation="MSISTLQKEINKQLDGCFEEMVEIRRHFHMYPELSFQEEKTAAF IASYYESLGVPIRTNVGGRGVLANIEGSEPGPTVALRADFDALPIQDEKDVPYASKVP GVMHACGHDGHTAALLAVAKVLHQNRHELKGTFVMIHQHAEEYYPGGAKPMIDDGCLE NTDVIFGTHLWATEPLGTILCRPGAVMAAADRFTIKVFGKGGHGAHPHDTKDAVLIGS QIVSSLQHIVSRKVNPIQSAVISTGSFIADNPFNVIADQAVLIGTARSFDENVRDILE KEIEAVVKGICSMHGASYEYTYEQGYPAVVNHPAETNHLVSTAKNTEGVQQVIDGEPQ MGGEDFAYYLQNVKGTFFFTGAAPEQPERVYSHHHPKFDINEKAMLTAAKVLAGAAIT YHQL*" /label="sndC CDS" gene complement(982312..983502) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /label="sndC gene" downshifts complement(982322) /Source="Nicolas_upshifts" /id="D547" /incds=0 /nref=11 /ntot=162 /MaxReadThrough="3.12546" /MaxDrop="4.15559" /score="-4.78420642" /energy="-14.6" /TU="U810" /idTUdmin="U811" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(982387) /Source="Nicolas_upshifts" /id="D548" /incds=1 /nref=25 /ntot=206 /MaxReadThrough="4.92378" /MaxDrop="3.21645" /score="-4.78420642" /energy="-14.6" /TU="U810,U811" /idTUdmin="U811" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(983526..983545) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(983547) /Source="Nicolas_upshifts" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(983559..983564) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(983575..984966) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 12107147; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388889.1" /db_xref="EnsemblGenomes-Gn:BSU10080" /db_xref="EnsemblGenomes-Tr:CAB12848" /db_xref="GOA:O07599" /db_xref="SubtiList:BG13047" /db_xref="UniProtKB/Swiss-Prot:O07599" /translation="MMEVGILPVHVLYVFFIGAIILFMLLRKDTTFISLFGIFIISLW ASHSLSASVSSLFHSFIYAAGELLPTIFIICFIVSMSDLLTKTGINEAMISPFASLVR GPVTAYWLIGGLMFAISLFFWPSPGVALIGAVLLPAAARAGLTPLAAAMAMNLFGHGF ALSGDFVIQAAPKLTADAAGIPVGDVVSASIPLVLIMGVTTTTAAFIMIQRERKKQEH PTSFSPVLSGEQDNSLYLPKRLRSILAFLIPLAFLADIACMLLFNLQGNDATALIGGS AICILFTVHFFVYKHKGLEKITGYFIDGFKFGFKVFGPVIPIAAFFYLGDSGYESILG TSLPKGSHGIVNDLGIALSHMMPMSKELAATALTAAGAITGLDGSGFSGISLAGSIAK LFSSALHADPAILTALGQISAIWVGGGTLVPWALIPAAAICKVDPFELARKNFIPVAI GLLVTTLAAVMML*" /label="yhfA CDS" gene complement(983575..984966) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /label="yhfA gene" promotor_-10 complement(984977..984996) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(984982) /Source="Nicolas_upshifts" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(985009..985018) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(985032..985346) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388890.1" /db_xref="EnsemblGenomes-Gn:BSU10090" /db_xref="EnsemblGenomes-Tr:CAB12849" /db_xref="SubtiList:BG10426" /db_xref="UniProtKB/Swiss-Prot:P38048" /translation="MKHTCPVCGFKDWLNRHMIMKAIILMKSARAAVFSSDLMSTRCS TRITHIEPSESIIAYRKNWLAEGCVIFSPECFPKHLQKANRGLRHHLIEQLKQINVHL PS*" /label="yhgB CDS" gene complement(985032..985346) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /label="yhgB gene" CDS complement(985391..985891) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /EC_number="1.14.99.48" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21873409, 22531134, 24582752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21873409, 22531134, 24582752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388891.1" /db_xref="EnsemblGenomes-Gn:BSU10100" /db_xref="EnsemblGenomes-Tr:CAB12850" /db_xref="GOA:P38049" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:4OZ5" /db_xref="SubtiList:BG10427" /db_xref="UniProtKB/Swiss-Prot:P38049" /translation="MKVYITYGTADFLKTIVQKHPSENILLMQGQENAILIHETNGDT VFQAPHAYEVIDQVGEIKHPGFAVLNNIAVTQEGRPLFENRFKNRAGKVENEPGFEAI RVLRPLDSDTYVILTLWETESAFQDWQQSGSYKEAHKKRDTSAGIDTTSIFSRPSYVT TYFAVE*" /label="hmoB CDS" gene complement(985391..985891) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /label="hmoB gene" downshifts complement(985418) /Source="Nicolas_upshifts" /id="D549" /incds=0 /nref=145 /ntot=254 /MaxReadThrough="3.45185" /MaxDrop="5.6374" /score="15.5142908" /energy="-14.8" /TU="U812" /idTUdmin="U812" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(985904..985923) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 985906..985910 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(985925) /Source="Nicolas_upshifts" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 985926..985945 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 985927 /Source="Nicolas_upshifts" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(985940..985941) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 985958..985964 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 985979..985990 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 985984 /Source="Nicolas_upshifts" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="upshifts" CDS 986013..988157 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8335642, 11567005, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8335642, 11567005, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2C (1F class) required for spore germination" /protein_id="NP_388892.2" /db_xref="EnsemblGenomes-Gn:BSU10110" /db_xref="EnsemblGenomes-Tr:CAB12851" /db_xref="GOA:P38050" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10428" /db_xref="UniProtKB/Swiss-Prot:P38050" /translation="MFKIKKKKLFIPIIILVLTAFLALIGYISIIFLGHYVIDEKKLI LHASSKIVDQNGDEVASLYTENREPVSINEIPKQVREAFIAVEDKRFYEHHGIDAKSV GRAVYRDILAGGKVEGGSTITQQLAKNIFLTHDKTFLRKTKEVIIAINLERDYSKDKL LEMYLNQLYFGHGVYGIQAASHYYFNKEVKDLTVSEGAVLAAIPKAPSTYSPILHPDK NKERRDTILGMMNDQGYISAKEAVTAQGRTLGLHVKKQSETPWFDSYIDLVIKEAEDK YSISGEQLLQGGYTIKVPLDSKLQKTAYQVMKEGSYYPGTDQNAEGSAVFINNKTGGV EAAIGGRDYTSKGYNRVTAVRQPGSTFKPLAVYGPAMQEKKFKPYSLLKDELQSYGDY TPKNYDSRYEGEVTMSDAITYSKNAPAVWTLNEIGVETGKSYLKANGIDIPDEGLALA LGGLEKGVSPLQLAGAFHTFAANGTYTEPFFISSIIDEDGETIADHKEEGKRVFSKQT SWNMTRMLQQVVKKGTATSGTYHGDLAGKTGSTSYTGVSGATKDAWFAGYTPKITGAV WMGYDKTDQNHYLKAGSSYPTRLFKDILTQAGETGHVFTKPKNVKELESPIELKPVKT LTADYTFKAAGLFTIELKWDAQEDDRAVYRIYVNKDGEETLLDSVEGKGSYEIPYANL FSGASYKIVPYNTQTKREGEGTDYVQPKLFSS*" /label="pbpF CDS" gene 986013..988157 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /label="pbpF gene" promotor_-10 complement(986057..986068) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(986060) /Source="Nicolas_upshifts" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(986082..986088) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 988194..988200 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 988214..988233 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 988224 /Source="Nicolas_upshifts" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" CDS 988279..989340 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /EC_number="4.1.1.37" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 17122346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 17122346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III decarboxylase" /protein_id="NP_388893.1" /db_xref="EnsemblGenomes-Gn:BSU10120" /db_xref="EnsemblGenomes-Tr:CAB12852" /db_xref="GOA:P32395" /db_xref="InterPro:IPR000257" /db_xref="InterPro:IPR006361" /db_xref="PDB:2INF" /db_xref="SubtiList:BG10429" /db_xref="UniProtKB/Swiss-Prot:P32395" /translation="MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEK YGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPLPSIGVDVEIKNGIGPVIDQ PIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGP SKNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQAD YRTYIKPVMNRIFSELAKENVPLIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARS KGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNLGHGVFPDVSPEVLK KLTAFVHEYSQNKKMGQYS*" /label="hemE CDS" gene 988279..989340 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /label="hemE gene" CDS 989412..990344 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /EC_number="4.99.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferrochelatase" /protein_id="NP_388894.1" /db_xref="EnsemblGenomes-Gn:BSU10130" /db_xref="EnsemblGenomes-Tr:CAB12853" /db_xref="GOA:P32396" /db_xref="InterPro:IPR001015" /db_xref="InterPro:IPR019772" /db_xref="InterPro:IPR033644" /db_xref="InterPro:IPR033659" /db_xref="PDB:1AK1" /db_xref="PDB:1C1H" /db_xref="PDB:1C9E" /db_xref="PDB:1DOZ" /db_xref="PDB:1FJI" /db_xref="PDB:1LD3" /db_xref="PDB:1N0I" /db_xref="PDB:2AC2" /db_xref="PDB:2AC4" /db_xref="PDB:2H1V" /db_xref="PDB:2H1W" /db_xref="PDB:2HK6" /db_xref="PDB:2Q2N" /db_xref="PDB:2Q2O" /db_xref="PDB:2Q3J" /db_xref="PDB:3GOQ" /db_xref="PDB:3M4Z" /db_xref="SubtiList:BG10430" /db_xref="UniProtKB/Swiss-Prot:P32396" /translation="MSRKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPEMLQDLK DRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAEMHK DGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLTITSVESWYDEPKFVTYWVDR VKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAEGAGVSEYAV GWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYECKVV TDDIGASYYRPEMPNAKPEFIDALATVVLKKLGR*" /label="hemH CDS" gene 989412..990344 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /label="hemH gene" CDS 990359..991771 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /EC_number="1.3.3.4" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9217019, 9784236, 10498703, 20543190" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9217019, 9784236, 10498703, 20543190; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous protoporphyrinogen IX and coproporphyrinogen III oxidase" /protein_id="NP_388895.1" /db_xref="EnsemblGenomes-Gn:BSU10140" /db_xref="EnsemblGenomes-Tr:CAB12854" /db_xref="GOA:P32397" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR004572" /db_xref="InterPro:IPR036188" /db_xref="PDB:3I6D" /db_xref="SubtiList:BG10431" /db_xref="UniProtKB/Swiss-Prot:P32397" /translation="MSDGKKHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASP RVGGKIQTVKKDGYIIERGPDSFLERKKSAPQLVKDLGLEHLLVNNATGQSYVLVNRT LHPMPKGAVMGIPTKIAPFVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRV GDEVVENLIEPLLSGIYAGDIDKLSLMSTFPQFYQTEQKHRSLILGMKKTRPQGSGQQ LTAKKQGQFQTLSTGLQTLVEEIEKQLKLTKVYKGTKVTKLSHSGSCYSLELDNGVTL DADSVIVTAPHKAAAGMLSELPAISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVI SRNSDFAITACTWTNKKWPHAAPEGKTLLRAYVGKAGDESIVDLSDNDIINIVLEDLK KVMNINGEPEMTCVTRWHESMPQYHVGHKQRIKELREALASAYPGVYMTGASFEGVGI PDCIDQGKAAVSDALTYLFS*" /label="hemY CDS" gene 990359..991771 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /label="hemY gene" downshifts 990362 /Source="Nicolas_upshifts" /id="D550" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="7.68191" /MaxDrop="2.667" /score="28.7532434" /energy="-11.6" /TU="U813,U816" /idTUdmin="U814" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 991748 /Source="Nicolas_upshifts" /id="D551" /incds=0 /nref=195 /ntot=254 /MaxReadThrough="2.9859" /MaxDrop="6.7703" /score="28.7532434" /energy="-11.6" /TU="NA" /idTUdmin="U813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 991832..991839 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 991853..991872 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 991858 /Source="Nicolas_upshifts" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" CDS 991917..992492 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15944459, 23695570; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown target" /protein_id="NP_388896.1" /db_xref="EnsemblGenomes-Gn:BSU10150" /db_xref="EnsemblGenomes-Tr:CAB12855" /db_xref="GOA:P32398" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10432" /db_xref="UniProtKB/Swiss-Prot:P32398" /translation="MSIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTF FKNKEELFDEIFTTLLKEMKQKADEAMEPSLPFHENVHRALFAILEFRKTHQLTIKIF QENAEIGTMAVQEVIQKMERSILSYIKSKIEDGIKSGAIKPCDPELTAFVMLKLYIAL IFDWEKQHPPLDKETIAGLLELYVVKGLSAN*" /label="yhgD CDS" gene 991917..992492 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /label="yhgD gene" promotor_-35 992236..992239 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 992254 /Source="Nicolas_upshifts" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 992256..992275 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 992493..992562 /Source="Nicolas_S_feature" /locus_tag="new_1090331_1090400" /HighExp="G135, G150, G180, BI, Salt, Etha, Cold, Heat, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.731, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S358" CDS 992563..994890 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576783; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting protein" /protein_id="NP_388897.1" /db_xref="EnsemblGenomes-Gn:BSU10160" /db_xref="EnsemblGenomes-Tr:CAB12856" /db_xref="GOA:P32399" /db_xref="InterPro:IPR017500" /db_xref="InterPro:IPR017501" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR023908" /db_xref="SubtiList:BG10433" /db_xref="UniProtKB/Swiss-Prot:P32399" /translation="MNTIRSQWKDIVTSKKLLIPIIAILFVPLIYSGVFLKAYWDPYG TVDQLPVVVVNQDKGATYEGEKLQIGDDLVKELKDNNNFDWHFSNDLDQSLKDLLNQK YYLVVEIPEDFSKNASTVLDKNPKKLDLKYHTNAGSNYVGATIGEKAIDKLKASVSKE VTEQYTKVIFDNFKDIAKGLSDASSGAKKIDDGTKDAKNGSAQLKENLAKLKESTATI SDKTAQLADGAAQVTSGIQSLDSSLGKFQDSSNQIYDKSSQLAAGSGELTSKMNELLA GLQNVQKGTPNLTNGLDQLNSKVQEGSEKAAKAEKIINALDLTKLETAVNNLEKSETA MKEFKKQLTDFENSLKNRDQAFKNVINSSDFLTAEQKSQLINSVEKKLPQVDAPDFDQ ILSQLPTADQLPDIATIKSSLEDVKAQVAQVKAMPEATSKLYNGAKTIQDAIDRLTEG ADKIYNGSQKLTDGQTKLTAGIGEYNKQFAKAKAGSEQLVTGSSQVSGGLFKLLDGSK QVQSGSSKLADGSASLDTGLGKLLDGTGELSSKLKDAADQTGDIDADDQTYGMFADPV KTKDDAIHSVPNYGTGLTPYILSMGLYVGGIMLTVVFPLKEASGRPRNGFEWFFSKFN VMMLVGIIQSLIVATVLLLGIGLEVESTWRFYVFTIITSLAFLAIIQFLATTMGNPGR FIAVIILVLQLGASGGTFPLELLPNFYQVIHGALPMTYSINGFRAVISNGDFGYMWQM AGVLIGIALVMIALSITYFTMLSRKEETSEEQPAS*" /label="yhgE CDS" gene 992563..994890 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /label="yhgE gene" downshifts 994872 /Source="Nicolas_upshifts" /id="D552" /incds=0 /nref=65 /ntot=211 /MaxReadThrough="0.57274" /MaxDrop="5.58483" /score="-4.79013797" /energy="-7.3" /TU="NA" /idTUdmin="U817" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(994932..995909) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 21383089, 21542858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 21383089, 21542858; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 2" /protein_id="NP_388898.1" /db_xref="EnsemblGenomes-Gn:BSU10170" /db_xref="EnsemblGenomes-Tr:CAB12857" /db_xref="GOA:O07600" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13048" /db_xref="UniProtKB/Swiss-Prot:O07600" /translation="MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERR IADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWE STGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGD AAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREV YKWAARTVPGEFERLLHKAGLSSDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVE HYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLLIKWGM*" /label="fabHB CDS" gene complement(994932..995909) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /label="fabHB gene" downshifts complement(994945) /Source="Nicolas_upshifts" /id="D553" /incds=0 /nref=21 /ntot=217 /MaxReadThrough="1.99012" /MaxDrop="7.90433" /score="-9.17544275" /energy="-7.3" /TU="NA" /idTUdmin="U819" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(995923..995942) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(995941) /Source="Nicolas_upshifts" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(995956..995962) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 995968..995976 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 995987..996005 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 995994 /Source="Nicolas_upshifts" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 996036..996812 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388899.1" /db_xref="EnsemblGenomes-Gn:BSU10180" /db_xref="EnsemblGenomes-Tr:CAB12858" /db_xref="GOA:O07601" /db_xref="InterPro:IPR011397" /db_xref="SubtiList:BG13049" /db_xref="UniProtKB/Swiss-Prot:O07601" /translation="MVSQEAVVFLALSGAIAFLLPIGLIVWFKRKYGASLKVFFIGAL TFFVFAQLLEGGVHVYVLQVNEMTKEAMQHPLWYGIYGCLMAGIFEECGRYLMMRFFM KRHHTWADGLAFGAGHGGLEAILITGLSSISLIVYAFAINSGTFEQLLVNGDVKQALL PIQEQLLHTPSYEWMLGGIERISAIAVQIGLSLLVLYAVKNRRPLFLLYSILLHALFN VPAVLYQRGIIEHAAAVEIIVALIAALSVYWIVKAKRVFQ*" /label="yhfC CDS" gene 996036..996812 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /label="yhfC gene" S_feature complement(996528..997149) /Source="Nicolas_S_feature" /locus_tag="new_1094366_1094987_c" /HighExp="B36, BT, B60, Pyr, S8, G/S, G135, Mal, M/G, Glucon" /AntisenseName="yhfC" /AntisenseCor="-0.12937903461570099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="0.51248700000000003" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S359" S_feature 996813..997184 /Source="Nicolas_S_feature" /locus_tag="new_1094651_1095022" /HighExp="Lbstat, S2, M0t90, M40t90, HiOs, SMMPr, T-2.40H, Etha, Lbtran, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48518699999999998" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S360" promotor_-10 complement(997127..997146) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(997148) /Source="Nicolas_upshifts" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(997160..997169) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 997162..997169 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 997184..997203 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 997186 /Source="Nicolas_upshifts" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 997225..998265 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15713475, 15743956; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminopeptidase" /protein_id="NP_388901.1" /db_xref="EnsemblGenomes-Gn:BSU10200" /db_xref="EnsemblGenomes-Tr:CAB12860" /db_xref="GOA:O07603" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13051" /db_xref="UniProtKB/Swiss-Prot:O07603" /translation="MTSVRKTMELIKELVSIPSPTGNTYEVINYIESLLKEWKVETVR NHKGGLIATLPGRDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLIGGFRYNSIEGEY CQIETASGKMYTGTILMHQTSVHVYKDAGKAERNQENMEIRLDEPVHCRKDTEELGIG VGDFVSFDPRVEITSSGFIKSRHLDDKASVALLLRLIHEIQTEDIELPYTTHFLISNN EEIGYGGNSNIPPETVEYLAVDMGAIGDGQATDEYSVSICVKDASGPYHYQLRKHLVQ LAEKHHIDYKLDIYPYYGSDASAAIKSGHDIVHGLIGPGIDASHAFERTHKSSLRHTA KLLYYYVQSPMV*" /label="yhfE CDS" gene 997225..998265 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /label="yhfE gene" CDS 998278..998685 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11157739, 14517985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding PUA-containing enzyme" /protein_id="NP_388902.1" /db_xref="EnsemblGenomes-Gn:BSU10210" /db_xref="EnsemblGenomes-Tr:CAB12861" /db_xref="InterPro:IPR007374" /db_xref="InterPro:IPR009326" /db_xref="InterPro:IPR015947" /db_xref="SubtiList:BG13052" /db_xref="UniProtKB/Swiss-Prot:O07604" /translation="MKIYKLKSTFGWEGDDGLGEQLIQQILAGEKSATCAPKSLYSKD ELRDVYQTAGQLVTVYDKHDNPRCNIKVTDVFETTFGAPDMRLVKGEGNGDRIEEFQE DHRMAWAELIKSGELELNEDTVLITELFVLVKD*" /label="yhfF CDS" gene 998278..998685 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /label="yhfF gene" downshifts 998656 /Source="Nicolas_upshifts" /id="D554" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="0.87656" /MaxDrop="5.21108" /score="22.0862441" /energy="-20.3" /TU="U822" /idTUdmin="U822" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(998722..1000011) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/sodium-glutamate (aspartate) symport permease" /protein_id="NP_388903.1" /db_xref="EnsemblGenomes-Gn:BSU10220" /db_xref="EnsemblGenomes-Tr:CAB12862" /db_xref="GOA:O07605" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12595" /db_xref="UniProtKB/Swiss-Prot:O07605" /translation="MKRIKFGLATQIFVGLILGVIVGVIWYGNPALPTYLQPIGDLFL RLIKMIVIPIVVSSLIIGVAGAGNGKQVGKLGFRTILYFEIITTFAIILGLALANIFH PGTGVNIHEAQKSDISQYVETEKEQSNKSVAETFLHIVPTNFFQSLVEGDLLAIICFT VLFALGISAIGERGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLGS LISLGKLVGLVYVALAFFLIVIFGIVAKIAGISIFKFLAYMKDEILLAFSTSSSETVL PRIMEKMEKIGCPKGIVSFVIPIGYTFNLDGSVLYQSIAALFLAQVYGIDLTIWHQIT LVLVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTG NALAAVVMSKWEGMFNPAKAETVMSQSKTEQNATISG*" /label="gltT CDS" gene complement(998722..1000011) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /label="gltT gene" downshifts complement(998752) /Source="Nicolas_upshifts" /id="D555" /incds=0 /nref=226 /ntot=280 /MaxReadThrough="2.99263" /MaxDrop="7.79183" /score="48.7726082" /energy="-21.9" /TU="U823" /idTUdmin="U824" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(1000012..1000112) /Source="Nicolas_S_feature" /locus_tag="new_1097850_1097950_c" /HighExp="C90, LoTm, LBGexp, Cold, UNK1, BC, dia5, Lbexp, S1, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S361" promotor_-10 complement(1000111..1000130) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1000112) /Source="Nicolas_upshifts" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1000114..1000250) /Source="Nicolas_S_feature" /locus_tag="new_1097952_1098088_c" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, T2.30H, T5.0H, Cold, T2.0H, S0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S362" promotor_-35 complement(1000145..1000151) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1000282..1000422) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388904.1" /db_xref="EnsemblGenomes-Gn:BSU10230" /db_xref="EnsemblGenomes-Tr:CAB12863" /db_xref="InterPro:IPR025432" /db_xref="SubtiList:BG13053" /db_xref="UniProtKB/Swiss-Prot:O07606" /translation="MVMLGKITEFFRNLPSKKCAECGKKIEEQHECYGNICNDCIKVN DL*" /label="yhfH CDS" gene complement(1000282..1000422) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /label="yhfH gene" downshifts complement(1000295) /Source="Nicolas_upshifts" /id="D556" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.70702" /MaxDrop="4.73949" /score="28.7665297" /energy="-13.6" /TU="U824" /idTUdmin="U824" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1000441..1000460) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1000460) /Source="Nicolas_upshifts" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1000473..1000480) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1000504..1000510 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1000524..1000543 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1000527 /Source="Nicolas_upshifts" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="upshifts" CDS 1000574..1001308 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388905.1" /db_xref="EnsemblGenomes-Gn:BSU10240" /db_xref="EnsemblGenomes-Tr:CAB12864" /db_xref="GOA:O07607" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13054" /db_xref="UniProtKB/Swiss-Prot:O07607" /translation="MKVTVIGCYGGFPAANEATSGYLFQSGDYSLLVDCGSAVLSKLF GYVPAEKLDAVVLSHYHHDHIADIGPLQFAKQVGSFLGKGEHTLPIYGHDADIEQFQK LTYKTHTKGIAYQPDQPLTAGPFTITFLKTIHPVTCYAMRITDGSHTVVYTADSSYQD SFIPFSKDADLLISECNFYADQDGTSAGHMNSLEAGRIAKEAGAGELLLTHLPHFGVH DNLRKEAKTVFNGEVNIAKSGFVWEG*" /label="yhfI CDS" gene 1000574..1001308 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /label="yhfI gene" CDS 1001321..1002316 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /EC_number="6.3.1.20" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoate-protein ligase" /protein_id="NP_388906.1" /db_xref="EnsemblGenomes-Gn:BSU10250" /db_xref="EnsemblGenomes-Tr:CAB12865" /db_xref="GOA:O07608" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004562" /db_xref="InterPro:IPR019491" /db_xref="SubtiList:BG13055" /db_xref="UniProtKB/Swiss-Prot:O07608" /translation="MLFIDNQNINDPRINLAIEEYCVKHLDPEQQYLLFYVNQPSIII GKNQNTIEEINTKYVEENGIIVVRRLSGGGAVYHDLGNLNFSFITKDDGDSFHNFKKF TEPVIQALHQLGVEAELSGRNDIVVDGRKISGNAQFATKGRIFSHGTLMFDSAIDHVV SALKVKKDKIESKGIKSIRSRVANISEFLDDKMTTEEFRSHLLRHIFNTNDVGNVPEY KLTEKDWETIHQISKERYQNWDWNYGRSPKFNLNHSKRYPVGSIDLHLEVKKGKIEDC KIFGDFFGVGDVSEIENLLVGKQYERSVIADVLEGVNLKHYFGNITKEDFLDLIY*" /label="lplJ CDS" gene 1001321..1002316 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /label="lplJ gene" CDS 1002381..1003025 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11790741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-binding epimerase / hydratase" /protein_id="NP_388907.1" /db_xref="EnsemblGenomes-Gn:BSU10260" /db_xref="EnsemblGenomes-Tr:CAB12866" /db_xref="GOA:O07609" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13056" /db_xref="UniProtKB/Swiss-Prot:O07609" /translation="MKVFLIGANGQIGQRLVSLFQDNPDHSIRAMVRKEEQKASLEAA GAEAVLANLEGSPEEIAAAAKGCDAIIFTAGSGGSTGYDKTLLVDLDGAAKAIEAAAI AGIKRFIMVSALQAHNRENWNEALKPYYVAKHYADKILEASGLTYTIIRPGGLRNEPG TGTVSAAKDLERGFISRDDVAKTVIASLDEKNTENRAFDLTEGDTPIAEALKKL*" /label="yhfK CDS" gene 1002381..1003025 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /label="yhfK gene" downshifts 1003013 /Source="Nicolas_upshifts" /id="D557" /incds=0 /nref=239 /ntot=258 /MaxReadThrough="0.56809" /MaxDrop="6.84076" /score="18.2092404" /energy="-10" /TU="NA" /idTUdmin="U825" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1003053..1003056 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1003071..1003090 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1003078 /Source="Nicolas_upshifts" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="upshifts" CDS 1003142..1004683 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long-chain fatty-acid-CoA ligase (degradative)" /protein_id="NP_388908.2" /db_xref="EnsemblGenomes-Gn:BSU10270" /db_xref="EnsemblGenomes-Tr:CAB12867" /db_xref="GOA:O07610" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13057" /db_xref="UniProtKB/Swiss-Prot:O07610" /translation="MNLVSKLEETASEKPDSIACRFKDHMMTYQELNEYIQRFADGLQ EAGMEKGDHLALLLGNSPDFIIAFFGALKAGIVVVPINPLYTPTEIGYMLTNGDVKAI VGVSQLLPLYESMHESLPKVELVILCQTGEAEPEAADPEVRMKMTTFAKILRPTSAAK QNQEPVPDDTAVILYTSGTTGKPKGAMLTHQNLYSNANDVAGYLGMDERDNVVCALPM FHVFCLTVCMNAPLMSGATVLIEPQFSPASVFKLVKQQQATIFAGVPTMYNYLFQHEN GKKDDFSSIRLCISGGASMPVALLTAFEEKFGVTILEGYGLSEASPVTCFNPFDRGRK PGSIGTSILHVENKVVDPLGRELPAHQVGELIVKGPNVMKGYYKMPMETEHALKDGWL YTGDLARRDEDGYFYIVDRKKDMIIVGGYNVYPREVEEVLYSHPDVKEAVVIGVPDPQ SGEAVKGYVVPKRSGVTEEDIMQHCEKHLAKYKRPAAITFLDDIPKNATGKMLRRALR DILPQ*" /label="lcfB CDS" gene 1003142..1004683 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /label="lcfB gene" downshifts 1004663 /Source="Nicolas_upshifts" /id="D558" /incds=0 /nref=5 /ntot=108 /MaxReadThrough="2.74134" /MaxDrop="3.72638" /score="15.3712924" /energy="-10.4" /TU="NA" /idTUdmin="U826" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1004722..1005117) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388909.1" /db_xref="EnsemblGenomes-Gn:BSU10280" /db_xref="EnsemblGenomes-Tr:CAB12868" /db_xref="SubtiList:BG13058" /db_xref="UniProtKB/Swiss-Prot:O07611" /translation="MKKIVAAIVVIGLVFIAFFYLYSRSGDVYQSVDADLITLSSSGQ EDIEIEKRQHVKDMLDIMNQGKQVKTEKTSAPDYEGTIKFHKDRYDSFRLWIDGSQQA VFLKDGTYYKLSKNDTKALLNIIKKEAKD*" /label="yhfM CDS" gene complement(1004722..1005117) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /label="yhfM gene" downshifts complement(1004739) /Source="Nicolas_upshifts" /id="D559" /incds=0 /nref=46 /ntot=89 /MaxReadThrough="0.75539" /MaxDrop="6.88759" /score="17.4775611" /energy="-10.4" /TU="NA" /idTUdmin="U827" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1005137..1005148) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1005141) /Source="Nicolas_upshifts" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1005163..1005169) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1005202..1005205 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1005213 /Source="Nicolas_upshifts" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1005220..1005239 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1005266..1006546 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /EC_number="3.4.24.84" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9015299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane metalloprotease" /protein_id="NP_388910.1" /db_xref="EnsemblGenomes-Gn:BSU10290" /db_xref="EnsemblGenomes-Tr:CAB12869" /db_xref="GOA:P40769" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR027057" /db_xref="InterPro:IPR032456" /db_xref="SubtiList:BG11029" /db_xref="UniProtKB/Swiss-Prot:P40769" /translation="MRKWIAAAGLAYVLYGLFFYWYFFLSGDSAIPEAVKGTQADPAS FMKPSELAVAEQYSNVKNFLFFIGVPLDWFLFFVLLVSGVSKKIKKWIEAAVPFRFLQ TVGFVFVLSLITTLVTLPLDWIGYQVSLDYNISTQTTASWAKDQVISFWISFPIFTLC VLVFYWLIKRHEKKWWLYAWLLTVPFSLFLFFIQPVIIDPLYNDFYPLKNKELESKIL ELADEANIPADHVYEVNMSEKTNALNAYVTGIGANKRIVLWDTTLNKLDDSEILFIMG HEMGHYVMKHVYIGLAGYLLVSLAGFYVIDKLYKRTVRLTRSMFHLEGRHDLAALPLL LLLFSVLSFAVTPFSNAVSRYQENKADQYGIELTENREAAVKTFQDLAVTGLSQVDPP VLVKIFRGSHPSIMERIQHAEKEENAPEHQDADK*" /label="yhfN CDS" gene 1005266..1006546 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /label="yhfN gene" promotor_-10 complement(1005693..1005712) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1005707) /Source="Nicolas_upshifts" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1005728..1005733) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1006533 /Source="Nicolas_upshifts" /id="D560" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="3.82026" /MaxDrop="3.6342" /score="6.45541384" /energy="-12.7" /TU="U828" /idTUdmin="U828" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(1006583) /Source="Nicolas_upshifts" /id="D561" /incds=0 /nref=129 /ntot=219 /MaxReadThrough="-0.11848" /MaxDrop="9.02627" /score="-6.76069514" /energy="-7.8" /TU="NA" /idTUdmin="U830" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1006585..1007730) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /EC_number="3.4.21.62" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine alkaline protease (Ca(2+)-dependent subtilisin E)" /protein_id="NP_388911.2" /db_xref="EnsemblGenomes-Gn:BSU10300" /db_xref="EnsemblGenomes-Tr:CAB12870" /db_xref="GOA:P04189" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="PDB:1SCJ" /db_xref="PDB:3WHI" /db_xref="SubtiList:BG10190" /db_xref="UniProtKB/Swiss-Prot:P04189" /translation="MRSKKLWISLLFALTLIFTMAFSNMSAQAAGKSSTEKKYIVGFK QTMSAMSSAKKKDVISEKGGKVQKQFKYVNAAAATLDEKAVKELKKDPSVAYVEEDHI AHEYAQSVPYGISQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLNVRGGASFVPSE TNPYQDGSSHGTHVAGTIAALNNSIGVLGVAPSASLYAVKVLDSTGSGQYSWIINGIE WAISNNMDVINMSLGGPTGSTALKTVVDKAVSSGIVVAAAAGNEGSSGSTSTVGYPAK YPSTIAVGAVNSSNQRASFSSAGSELDVMAPGVSIQSTLPGGTYGAYNGTSMATPHVA GAAALILSKHPTWTNAQVRDRLESTATYLGNSFYYGKGLINVQAAAQ*" /label="aprE CDS" gene complement(1006585..1007730) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /label="aprE gene" S_feature complement(1007731..1007797) /Source="Nicolas_S_feature" /locus_tag="new_1105569_1105635_c" /HighExp="BC, T5.0H, LoTm, Sw, T4.0H, T3.30H, S1, T3.0H, S2, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S363" promotor_-10 complement(1007786..1007805) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1007803) /Source="Nicolas_upshifts" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1007821..1007825) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1008110..1008117 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-35" promotor_-10 1008132..1008151 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-10" upshifts 1008134 /Source="Nicolas_upshifts" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="upshifts" CDS 1008165..1008614 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /EC_number="2.3.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388912.1" /db_xref="EnsemblGenomes-Gn:BSU10310" /db_xref="EnsemblGenomes-Tr:CAB12871" /db_xref="GOA:O07614" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13059" /db_xref="UniProtKB/Swiss-Prot:O07614" /translation="MNIRQAKTSDAAAIAPLFNQYREFYRQASDLQGAEAFLKARLEN HESVILIAEENGEFIGFTQLYPTFSSVSMKRIYILNDLFVVPHARTKGAGGRLLSAAK DYAGQNGAKCLTLQTEHHNRKARSLYEQNGYEEDTGFVHYCLNVPAK*" /label="yhfO CDS" gene 1008165..1008614 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /label="yhfO gene" promotor_-35 1008630..1008637 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1008652..1008671 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1008659 /Source="Nicolas_upshifts" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1008686..1009678 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9643546, 12057962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388913.1" /db_xref="EnsemblGenomes-Gn:BSU10320" /db_xref="EnsemblGenomes-Tr:CAB12872" /db_xref="GOA:O07615" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014188" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="PDB:1TT7" /db_xref="PDB:1Y9E" /db_xref="SubtiList:BG13060" /db_xref="UniProtKB/Swiss-Prot:O07615" /translation="MSTLFQALQAEKNADDVSVHVKTISTEDLPKDGVLIKVAYSGIN YKDGLAGKAGGNIVREYPLILGIDAAGTVVSSNDPRFAEGDEVIATSYELGVSRDGGL SEYASVPGDWLVPLPQNLSLKEAMVYGTAGFTAALSVHRLEQNGLSPEKGSVLVTGAT GGVGGIAVSMLNKRGYDVVASTGNREAADYLKQLGASEVISREDVYDGTLKALSKQQW QGAVDPVGGKQLASLLSKIQYGGSVAVSGLTGGGEVPATVYPFILRGVSLLGIDSVYC PMDVRAAVWERMSSDLKPDQLLTIVDREVSLEETPGALKDILQNRIQGRVIVKL*" /label="yhfP CDS" gene 1008686..1009678 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /label="yhfP gene" downshifts 1009679 /Source="Nicolas_upshifts" /id="D562" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="4.4421" /MaxDrop="2.9095" /score="14.183693" /energy="-15.3" /TU="U831,U832" /idTUdmin="U831" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" S_feature 1009724..1009834 /Source="Nicolas_S_feature" /locus_tag="new_1107562_1107672" /HighExp="Etha, dia15, LoTm, Salt, H2O2, LBGexp, Diami, Paraq, dia5, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S364" promotor_-35 1009812..1009819 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1009835..1009854 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1009836 /Source="Nicolas_upshifts" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1009895..1010866 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16672620, 20147287; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III) siderophore-binding lipoprotein" /protein_id="NP_388914.2" /db_xref="EnsemblGenomes-Gn:BSU10330" /db_xref="EnsemblGenomes-Tr:CAB12873" /db_xref="GOA:C0SP94" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG13061" /db_xref="UniProtKB/Swiss-Prot:C0SP94" /translation="MKKTLIILTVLLLSVLTAACSSSSGNQNSKEHKVAVTHDLGKTN VPEHPKRVVVLELGFIDTLLDLGITPVGVADDNKAKQLINKDVLKKIDGYTSVGTRSQ PSMEKIASLKPDLIIADTTRHKKVYDQLKKIAPTIALNNLNADYQDTIDASLTIAKAV GKEKEMEKKLTAHEEKLSETKQKISANSQSVLLIGNTNDTIMARDENFFTSRLLTQVG YRYAISTSGNSDSSNGGDSVNMKMTLEQLLKTDPDVIILMTGKTDDLDADGKRPIEKN VLWKKLKAVKNGHVYHVDRAVWSLRRSVDGANAILDELQKEMPAAKK*" /label="yhfQ CDS" gene 1009895..1010866 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /label="yhfQ gene" downshifts 1010845 /Source="Nicolas_upshifts" /id="D563" /incds=0 /nref=172 /ntot=251 /MaxReadThrough="2.22013" /MaxDrop="5.6726" /score="27.9181244" /energy="-10.9" /TU="NA" /idTUdmin="U833" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1010898..1011479) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10869096, 11827481, 12870714, 17693564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869096, 11827481, 12870714, 17693564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase; putative (phosphoglycerate) mutase" /protein_id="NP_388915.1" /db_xref="EnsemblGenomes-Gn:BSU10340" /db_xref="EnsemblGenomes-Tr:CAB12874" /db_xref="GOA:O07617" /db_xref="InterPro:IPR001345" /db_xref="InterPro:IPR013078" /db_xref="InterPro:IPR029033" /db_xref="SubtiList:BG13062" /db_xref="UniProtKB/Swiss-Prot:O07617" /translation="MTAVCLVRHGETDWNLQQKCQGKTDIPLNATGERQARETGEYVK DFSWDIIVTSPLKRAKRTAEIINEYLHLPIVEMDDFKERDYGDAEGMPLEERTKRYPD NIYPNMETLEELTDRLMGGLAKVNQAYPNKKVLIVAHGAAIHALLTEISGGDPELQST RLVNACLSNIEFAEEKWRIKDYNINSHLSGFIK*" /label="phoE CDS" gene complement(1010898..1011479) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /label="phoE gene" downshifts complement(1010921) /Source="Nicolas_upshifts" /id="D564" /incds=0 /nref=218 /ntot=256 /MaxReadThrough="1.23197" /MaxDrop="6.359" /score="28.9228703" /energy="-10.9" /TU="NA" /idTUdmin="U834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1011503..1011522) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1011515) /Source="Nicolas_upshifts" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1011538..1011541) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1011550..1012644) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /EC_number="2.3.1.9" /experiment="publication(s) with functional evidences, PMID:12368242, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acetyltransferase" /protein_id="NP_388916.1" /db_xref="EnsemblGenomes-Gn:BSU10350" /db_xref="EnsemblGenomes-Tr:CAB12875" /db_xref="GOA:O07618" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG13063" /db_xref="UniProtKB/Swiss-Prot:O07618" /translation="MNAVIVDAKRTIFGNQNGLLKPFLPEDLAAPIIRCLSRKLEDQV DEVILGNATGRGGNLARLSALQAGLPLSVPGMTIDRQCGSGLEAVRYACSLIQAGAGT MYIAGGSESSSQSPFSERARFSPDAIGDPDMGIAAEYTAARYSISRSMQDEYALLSHQ RSRNAHDEGFYREEVVALGELETDEAFLKTRPIEAIIPRAKPVFDTSSGTVTAANSSG IADGAAALLVMEEEKAAALGLKPVLRFIGSAVSGIHPNFPPAAPVVAIRQLLHTHDVT PDDIDLFEINEAFAVKICVCSQELGIPFSKINVRGGALALGHPYGASGAALVTRLFYE AKRRPDCQYAVAAIGSGGGIGLALLFEVLA*" /label="yhfS CDS" gene complement(1011550..1012644) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /label="yhfS gene" CDS complement(1012641..1014080) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12368242, 28032445, 28414710; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative long-chain fatty-acid-CoA ligase (proofreading for biotin synthesis)" /protein_id="NP_388917.1" /db_xref="EnsemblGenomes-Gn:BSU10360" /db_xref="EnsemblGenomes-Tr:CAB12876" /db_xref="GOA:O07619" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13064" /db_xref="UniProtKB/Swiss-Prot:O07619" /translation="MTITHTYSSTAETSPGRVAIQTESEQITYHDWDRLVSQTANWLR SQPSMPNRVAILLPNSLAFLQLFAGAAAAGCTAIPIDTRWSPAECKERLSISNADLVV TLAFFKNKLTDSQTPVVLLDNCMADISEAAADPLPTIDPEHPFYMGFTSGSTGKPKAF TRSHRSWMESFTCTETDFSISSDDKVLIPGALMSSHFLYGAVSTLFLGGTVCLLKKFS PAKAKEWLCRESISVLYTVPTMTDALARIEGFPDSPVKIISSGADWPAESKKKLAAAW PHLKLYDFYGTSELSFVTFSSPEDSKRKPHSAGRPFHNVRIEIRNAGGERCQPGEIGK IFVKSPMRFSGYVNGSTPDEWMTVDDMGYVDEEGFLYISGRENGMIVYGGLNIFPEEI ERVLLACPEVESAAVVGIPDEYWGEIAVAVILGNANARTLKAWCKQKLASYKIPKKWV FADSLPETSSGKIARSRVKKWLEESVQYK*" /label="yhfT CDS" gene complement(1012641..1014080) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /label="yhfT gene" CDS complement(1014087..1014647) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12368242, 15849754, 16850406, 18931129, 23709504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="biotin transporter" /protein_id="NP_388918.1" /db_xref="EnsemblGenomes-Gn:BSU10370" /db_xref="EnsemblGenomes-Tr:CAB12877" /db_xref="GOA:O07620" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13065" /db_xref="UniProtKB/Swiss-Prot:O07620" /translation="MLKLIDMMHIAIFTALMAVLGFMPPLFLSFTPVPITLQTLGVML AGSILRPKSAFLSQLVFLLLVAFGAPLLPGGRGGFGVFFGPSAGFLIAYPLASWLISL AANRLRKVTVLRLFFTHIVFGIIFIYLLGIPVQAFIMHIDLSQAAFMSLAYVPGDLIK AAVSAFLAIKITQALSLSDTMFTKGG*" /label="bioY CDS" gene complement(1014087..1014647) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /label="bioY gene" misc_feature complement(1014097..1014116) /Source="Nicolas_upshift_promotors" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1014111) /Source="Nicolas_upshifts" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1014672..1014691) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1014686) /Source="Nicolas_upshifts" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1014706..1014713) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1014782..1016080) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="heme-based dioxygen sensor" /protein_id="NP_388919.1" /db_xref="EnsemblGenomes-Gn:BSU10380" /db_xref="EnsemblGenomes-Tr:CAB12878" /db_xref="GOA:O07621" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR009050" /db_xref="PDB:1OR4" /db_xref="PDB:1OR6" /db_xref="SubtiList:BG13066" /db_xref="UniProtKB/Swiss-Prot:O07621" /translation="MLFKKDRKQETAYFSDSNGQQKNRIQLTNKHADVKKQLKMVRLG DAELYVLEQLQPLIQENIVNIVDAFYKNLDHESSLMDIINDHSSVDRLKQTLKRHIQE MFAGVIDDEFIEKRNRIASIHLRIGLLPKWYMGAFQELLLSMIDIYEASITNQQELLK AIKATTKILNLEQQLVLEAFQSEYNQTRDEQEEKKNLLHQKIQETSGSIANLFSETSR SVQELVDKSEGISQASKAGTVTSSTVEEKSIGGKKELEVQQKQMNKIDTSLVQIEKEM VKLDEIAQQIEKIFGIVTGIAEQTNLLSLNASIESARAGEHGKGFAVVANEVRKLSED TKKTVSTVSELVNNTNTQINIVSKHIKDVNELVSESKEKMTQINRLFDEIVHSMKISK EQSGKIDVDLQAFLGGLQEVSRAVSHVAASVDSLVILTEE*" /label="hemAT CDS" gene complement(1014782..1016080) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /label="hemAT gene" downshifts complement(1014793) /Source="Nicolas_upshifts" /id="D565" /incds=0 /nref=209 /ntot=243 /MaxReadThrough="2.70691" /MaxDrop="6.97357" /score="5.86442746" /energy="-6.9" /TU="NA" /idTUdmin="U837" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1016134..1016152) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1016137) /Source="Nicolas_upshifts" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1016166..1016172) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1016219..1017748) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with Rieske [2Fe-2S] center" /protein_id="NP_388920.1" /db_xref="EnsemblGenomes-Gn:BSU10390" /db_xref="EnsemblGenomes-Tr:CAB12879" /db_xref="GOA:O07622" /db_xref="InterPro:IPR005805" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG13067" /db_xref="UniProtKB/Swiss-Prot:O07622" /translation="MANQHFAKEAPETYWKTSTDLPSFPALQEDTECDVTIIGGGITG ITTAYELTKRGFRVVLIEANQVLNGTTAHTTAKVTAQHDMIYDEFIRHFGLNHARLYY EANQNAIDYIKGIVDEHQIDCEWIEQDAYLYTANENAVQKIHTEHEAYTKLGIERDLI KDLPIPLGSKLALVMKNQAQFHPLQYLKALLEQIVQKGGRIYEETVALDIKKGERPEV VTKSRHAIKSRFIICCSHFPFYDGGGLYAARMYSDRSYVLAIKPKIEYPEGMYLSIDQ PSVALRYTVVNGEKLILFSGVSHKTGQGKAMSTHYETLRQLAESTIGIESIPYYWSTQ DLVTIDKIPFIGPMSENEDNILVATGFKKWGMTSSAVAATLLSDLVEKKENPYESIFT PSRFHLNPGLQKVISYNADVAKHLIKGKLEKPDVQFEDISPGEGKAVTINGRRAGAFR DETGCLHLVDTTCTHLGCEVEWNDSEHTWDCPCHGSRFKPSGEVVEGPAIKPLKQIDL D*" /label="yhfW CDS" gene complement(1016219..1017748) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /label="yhfW gene" promotor_-10 complement(1017775..1017793) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1017785) /Source="Nicolas_upshifts" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1017804..1017809 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1017808..1017813) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1017821 /Source="Nicolas_upshifts" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1017825..1017843 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1017860..1018717 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18643936, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388921.1" /db_xref="EnsemblGenomes-Gn:BSU10400" /db_xref="EnsemblGenomes-Tr:CAB12880" /db_xref="GOA:P40397" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11058" /db_xref="UniProtKB/Swiss-Prot:P40397" /translation="MANQKKKTLPPQHQNQQPGFEYLMDPRPVFDKPKKAKKLEGKTA IITGGDSGIGRAVSVLFAKEGANVVIVYLNEHQDAEETKQYVEKEGVKCLLIAGDVGD EAFCNDVVGQASQVFPSIDILVNNAAEQHVQPSIEKITSHQLIRTFQTNIFSMFYLTK AVLPHLKKGSSIINTASITAYKGNKTLIDYSATKGAIVTFTRSLSQSLVQQGIRVNAV APGPIWTPLIPASFAAKDVEVFGSDVPMERPGQPVEVAPSYLYLASDDSTYVTGQTIH VNGGTIVNG*" /label="yhxC CDS" gene 1017860..1018717 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /label="yhxC gene" downshifts 1018699 /Source="Nicolas_upshifts" /id="D566" /incds=0 /nref=10 /ntot=36 /MaxReadThrough="2.65833" /MaxDrop="4.80135" /score="-8.69335909" /energy="-4.5" /TU="NA" /idTUdmin="U839" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1018745..1018978) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388922.1" /db_xref="EnsemblGenomes-Gn:BSU10410" /db_xref="EnsemblGenomes-Tr:CAB12881" /db_xref="InterPro:IPR014957" /db_xref="SubtiList:BG13087" /db_xref="UniProtKB/Swiss-Prot:O31594" /translation="MKEKKSYTELMKSRNTQKTKEFDVTMTDIYIQMVLDESLYNRRL AMLTDQINKALDEKDKDAFLTLSKEYAALKQSE*" /label="yhzC CDS" gene complement(1018745..1018978) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /label="yhzC gene" downshifts complement(1018778) /Source="Nicolas_upshifts" /id="D567" /incds=0 /nref=191 /ntot=247 /MaxReadThrough="3.34616" /MaxDrop="7.00218" /score="21.4902337" /energy="-12.3" /TU="U841" /idTUdmin="U844" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1018995..1019014) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1018998..1018999 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1018998 /Source="Nicolas_upshifts" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1019002..1019017 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1019017) /Source="Nicolas_upshifts" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1019019..1019874) /Source="Nicolas_S_feature" /locus_tag="new_1116857_1117712_c" /HighExp="Salt, Etha, C30, Heat, S8, LPhT, Gly, C90, S7, UNK1" /AntisenseName="comK" /AntisenseCor="-5.68778941053006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S365" promotor_-35 complement(1019029..1019036) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1019201..1019208 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-35" promotor_-10 1019220..1019239 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-10" upshifts 1019226 /Source="Nicolas_upshifts" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="upshifts" CDS 1019271..1019849 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" /label="comK CDS" gene 1019271..1019849 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /label="comK gene" S_feature 1019850..1019995 /Source="Nicolas_S_feature" /locus_tag="new_1117688_1117833" /HighExp="GM 150, C30, T-4.40H, T-3.40H, GM 120, M9-tran, T-2.40H, C90, G/S, T-1.10H" /AntisenseName="yhxD" /AntisenseCor="-0.229484184862048" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S366" CDS complement(1019896..1020795) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388924.1" /db_xref="EnsemblGenomes-Gn:BSU10430" /db_xref="EnsemblGenomes-Tr:CAB12883" /db_xref="GOA:P40398" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11060" /db_xref="UniProtKB/Swiss-Prot:P40398" /translation="MSDSNLTNPIKAFFHDEFPEQYQEPPGLQKNMKPVPDCGEKSYK GSGKLTGRKALVTGGDSGIGRAAAIAYAREGADVAINYLPEEQPDAEEVKELIEAEGR KAVLIPGDLSDESFCQDLVKQSHHELGGLDVLALVAGKQQAVENIEDLPTEQIYKTFE VNVFSLYWVVKAALPYLPEGASIITTTSVEGYNPSPMLLDYAATKNAIIGFTVGLGKQ LASKGIRVNSVAPGPIWTPLQISGGQPTENIPKFGQGTPPAPLNRAGQPVELADVYVF LASENSSYVTSQVYGITGGIPTA*" /label="yhxD CDS" gene complement(1019896..1020795) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /label="yhxD gene" downshifts complement(1019919) /Source="Nicolas_upshifts" /id="D568" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="4.95535" /MaxDrop="4.1467" /score="-2.68458203" /energy="-14.6" /TU="U844" /idTUdmin="U844" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1019982..1019985 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1019997 /Source="Nicolas_upshifts" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1020003..1020007 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1020041 /Source="Nicolas_upshifts" /id="D569" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="5.45904" /MaxDrop="5.6543" /score="-8.69335909" /energy="-4.5" /TU="U842" /idTUdmin="U843" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1020086..1020952 /Source="Nicolas_S_feature" /locus_tag="new_1117924_1118790" /HighExp="GM 150, C30, T-4.40H, C90, T-3.40H, T-2.40H, G/S, T-5.40H, M9-tran, nit" /AntisenseName="yhxD" /AntisenseCor="-0.32746434250834699" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S367" promotor_-10 complement(1020822..1020840) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1020839) /Source="Nicolas_upshifts" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1020855..1020861) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1020929..1020936 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1020951..1020970 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1020954 /Source="Nicolas_upshifts" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1021012..1021281 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388925.1" /db_xref="EnsemblGenomes-Gn:BSU10440" /db_xref="EnsemblGenomes-Tr:CAB12884" /db_xref="InterPro:IPR008613" /db_xref="SubtiList:BG13068" /db_xref="UniProtKB/Swiss-Prot:O07555" /translation="MKKAAAVLLSLGLVFGFSYGAGHVAEAKTKVKVYKNCKELNKVY KGGVARTSKVKNKGGKTKYKPYVSKALYDANKNKDRDKDLIACER*" /label="yhjA CDS" gene 1021012..1021281 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /label="yhjA gene" downshifts 1021273 /Source="Nicolas_upshifts" /id="D570" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.67325" /MaxDrop="7.59695" /score="27.4895724" /energy="-11.2" /TU="NA" /idTUdmin="U845" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1021321) /Source="Nicolas_upshifts" /id="D571" /incds=0 /nref=11 /ntot=113 /MaxReadThrough="2.40747" /MaxDrop="4.60953" /score="20.2036192" /energy="-11.2" /TU="NA" /idTUdmin="U846" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1021324..1022793) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite cotransporter" /protein_id="NP_388926.1" /db_xref="EnsemblGenomes-Gn:BSU10450" /db_xref="EnsemblGenomes-Tr:CAB12885" /db_xref="GOA:O07556" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13069" /db_xref="UniProtKB/Swiss-Prot:O07556" /translation="MNAALIIIFGVLLLSIFLGIRAQKGKDMNLEQWTVGGRGFGTVF VFLLMAGEIYTTFTFLGGSGWAYGKGGPAFYIIAYGCLAYILSYWLLPAVWTYAKQHK LMSQSDFFTKKYNSPLLGILVSLVGIAALIPYLVLQLKGLGLIVSETSYGKITPTAAI WIGAVSITVYVMVSGIHGSAWISVVKDIMILVVVLFLGVYLPIHYYGGFQDMFQQIET AKPGFLTLPESGQSVAWFSSTVLLTALGFYMWPHTFSASYSAENPKVFRKNAIIMPLY QLVLLFVLFVGFAAILQVPDLNGADGDLSLLRLSLQAFDPWFVGIIGAAGLLTALVPG SMILMSASTLFAKNVYKVIAPRTTEQQVSALAKFLVPVIALISVYFTFKGGNTIVTLL LMGYSLVTQLFPALLFSLLKHNMVTKQGAFAGIIAGVGAVTYITMTETTIGTLFPALP QAAKDLNVGIVALLLNITVMMAVSLMTRKAKSAAADQAA*" /label="yhjB CDS" gene complement(1021324..1022793) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /label="yhjB gene" CDS complement(1022790..1022990) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388927.1" /db_xref="EnsemblGenomes-Gn:BSU10460" /db_xref="EnsemblGenomes-Tr:CAB12886" /db_xref="GOA:O07557" /db_xref="InterPro:IPR021741" /db_xref="SubtiList:BG13070" /db_xref="UniProtKB/Swiss-Prot:O07557" /translation="MKLIHVLAALPFIGILLGIPFANKVTPYVFGMPFILAYIVMWAL LTSALMAIVYVLDKENKKEEAE*" /label="yhjC CDS" gene complement(1022790..1022990) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /label="yhjC gene" S_feature complement(1022991..1023109) /Source="Nicolas_S_feature" /locus_tag="new_1120829_1120947_c" /HighExp="S1, Etha, HiOs, MG 120, LoTm, T-5.40H, S2, GM-0.1, GM-0.2, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S368" promotor_-10 complement(1023092..1023111) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1023109) /Source="Nicolas_upshifts" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1023124..1023131) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1023197) /Source="Nicolas_upshifts" /id="D572" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.99656" /MaxDrop="2.67326" /score="20.2036192" /energy="-11.2" /TU="U848" /idTUdmin="U848" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(1023198..1023560) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388928.1" /db_xref="EnsemblGenomes-Gn:BSU10470" /db_xref="EnsemblGenomes-Tr:CAB12887" /db_xref="GOA:O07558" /db_xref="SubtiList:BG13071" /db_xref="UniProtKB/Swiss-Prot:O07558" /translation="MPNLQEEIYDLIERALFLPMAITIFNRDLAGIEESTLKLKHPYK QLISESLKIAQKDLMEVRKELRKRKIAIRETERDEAFTLYTFVIDGYEENHRYFNPRI REQVSELLTYYLFAPDRL*" /label="yhjD CDS" gene complement(1023198..1023560) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /label="yhjD gene" promotor_-35 1023398..1023403 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1023419..1023437 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1023420 /Source="Nicolas_upshifts" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1023429..1023668 /Source="Nicolas_S_feature" /locus_tag="new_1121267_1121506" /HighExp="S6, S4, S8, S5, LoTm, B36, S3, S7, BT, B60" /AntisenseName="yhjD" /AntisenseCor="0.24202608585419999" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S369" promotor_-10 complement(1023590..1023609) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1023608) /Source="Nicolas_upshifts" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1023624..1023631) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1023650..1023657 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1023670 /Source="Nicolas_upshifts" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1023671..1023690 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1023712..1024335 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388929.1" /db_xref="EnsemblGenomes-Gn:BSU10480" /db_xref="EnsemblGenomes-Tr:CAB12888" /db_xref="GOA:O07559" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13072" /db_xref="UniProtKB/Swiss-Prot:O07559" /translation="MLEHFLSYLTQEHLTELFQSYRAFGPLIAVLLPLIEAFLPFLPL IVFVVANTNSFGLWEGFILSWAGSTAGSILVFLIVRQYGQRKLLGFIRSHPSVRKLML WVERHGFGPMFLLLCFPFTPSAAVNVVAGLSRIGTRPFILAAASGKLVMIFMISFIGY DLHALITQPIRTVIAVLVITVLWYVGKKVERYLHVRASQREHDGGRQ*" /label="yhjE CDS" gene 1023712..1024335 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /label="yhjE gene" CDS 1024337..1024843 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /EC_number="3.4.21.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9325333, 9694797, 11309398, 12897006, 14568161, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 9694797, 11309398, 12897006, 14568161, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388930.1" /db_xref="EnsemblGenomes-Gn:BSU10490" /db_xref="EnsemblGenomes-Tr:CAB12889" /db_xref="GOA:O07560" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG12674" /db_xref="UniProtKB/Swiss-Prot:O07560" /translation="MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNE LLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGLPGETIKYKDDQLYVNGKQVAEP FLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNI VGVISDAE*" /label="sipV CDS" gene 1024337..1024843 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /label="sipV gene" downshifts 1024836 /Source="Nicolas_upshifts" /id="D573" /incds=0 /nref=131 /ntot=250 /MaxReadThrough="0.63331" /MaxDrop="4.58282" /score="-7.37718733" /energy="-7.1" /TU="NA" /idTUdmin="U847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1024894..1024901 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1024915..1024934 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1024924..1025023 /Source="Nicolas_S_feature" /locus_tag="new_1122762_1122861" /HighExp="LBGstat, LBGexp, Lbtran, C90, dia0, Lbexp, HPh, dia5, aero, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S370" upshifts 1024924 /Source="Nicolas_upshifts" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="upshifts" CDS 1025024..1026523 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7678243, 15121720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic compound monooxygenase/hydroxylase" /protein_id="NP_388931.1" /db_xref="EnsemblGenomes-Gn:BSU10500" /db_xref="EnsemblGenomes-Tr:CAB12890" /db_xref="GOA:O07561" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13073" /db_xref="UniProtKB/Swiss-Prot:O07561" /translation="MMMKYEAVIIGGGPVGFMLASELAIAGVGTCVIERLEKPVPHSK ALTLHPRTLELLEMRGILERFVSKGSKIPTGHFSMLDTRLDFSGLDTSCPYTLLLPQS KTEKLLEDHARSLGTEVFRGAEALAVTQNGEAVQTIFKDRDGSVRTITSKFAVGADGA GSTVRKQAKIEFPGTDSTVTAALGDVVLLSPPPSGVLSLCTKEGGVMIVPLSPDRYRV VVISPYRTQTPKDVPVTEEELKADLLRICGTDFGLTDPSWMSRFGNAARQAKRYRDGR IFLAGDAAHIHFPAGGQGLNVGLQDAMNLGWKLAAAIKGSAPSWLLDSYHDERHPAAE GLLRNTEAQTKLIDFTQAGLHLRSMMSELLAFPDVNRYVAGQISALDVRYEADRTMPP NRLNGARLPDMKLILSDGNSERLYSFLQNGTFVLLSLRQEADDHIEVKGLRTVTASLA EPNEKLRNVHTILIRPDGHVAWAVDASAPDCSEVIQKGISRWFSVTSRV*" /label="yhjG CDS" gene 1025024..1026523 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /label="yhjG gene" promotor_-35 1026531..1026538 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1026550 /Source="Nicolas_upshifts" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1026552..1026571 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1026600..1027127 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388932.1" /db_xref="EnsemblGenomes-Gn:BSU10510" /db_xref="EnsemblGenomes-Tr:CAB12891" /db_xref="GOA:Q796S4" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13074" /db_xref="UniProtKB/Swiss-Prot:Q796S4" /translation="MNTDHTKRNLFELYAELIHQQEKWEGLIKAFLSDELRKLDVEHG SKSQLTMTEIHVLSCVGDNEPINVTSIAEKMNTTKATVSRISTKLLGAGFLHRTQLSD NKKEVYFRLTPAGKKLHSLHKYYHQKAEQRFLSFFDRYTEEEILFAERLFRDLVTKWY PSSEEIEGGLPSIFK*" /label="yhjH CDS" gene 1026600..1027127 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /label="yhjH gene" downshifts 1027089 /Source="Nicolas_upshifts" /id="D574" /incds=0 /nref=8 /ntot=128 /MaxReadThrough="1.1509" /MaxDrop="3.41655" /score="11.3050978" /energy="-9.9" /TU="NA" /idTUdmin="U851" /TUdmin=8 /isTUend="TRUE" /label="downshifts" S_feature complement(1027141..>1027161) /Source="Nicolas_S_feature" /locus_tag="new_1124979_1125122_c" /HighExp="B36, B60, T0.30H, LBGstat, T1.30H, T1.0H, LPhT, LBGtran, Diami, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S371" SCAR join(1027161,1027177) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_001" N_region 1027162..1027176 /note="inserted sequence possibly derived from two restrictions with NotI and SacI" /created_by="User" /modified_by="User" /label="IIG_Bs27_001" S_feature <1027177..1027463 /Source="Nicolas_S_feature" /locus_tag="new_1130705_1131082" /HighExp="T4.0H, T5.0H, T3.30H, T2.0H, HiOs, T2.30H, T3.0H, LoTm, T1.30H, Pyr" /AntisenseName="yhjN" /AntisenseCor="-5.0383887616073E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig="0.997" /label="S375" S_feature complement(<1027177..1027298) /Source="Nicolas_S_feature" /locus_tag="new_1130759_1130917_c" /HighExp="B60, Sw, Cold, B36, BI, GM 15, GM 10, C30, GM 25, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S376" downshifts complement(1027183) /Source="Nicolas_upshifts" /id="D577" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="3.07371" /MaxDrop="4.24831" /score="-1.9470655" /energy="-7.1" /TU="U856" /idTUdmin="U856" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1027299..1028453) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (recentHGT island)" /protein_id="NP_388938.1" /db_xref="EnsemblGenomes-Gn:BSU10570" /db_xref="EnsemblGenomes-Tr:CAB12897" /db_xref="GOA:O07568" /db_xref="InterPro:IPR007820" /db_xref="InterPro:IPR017516" /db_xref="SubtiList:BG13080" /db_xref="UniProtKB/Swiss-Prot:O07568" /translation="MKKDENLLKDLWFIAISAAGGFILSLTGISIGWMIGTLIVACCL AMIRPAWLMMAPDQKGINRRWLALGQMILGIELGQKLNLSVLSVLKDHWFSVGVMLIL SILLAMLSGYVLWRFSKTDMMTSFVGTAPGGLSAMPSIAQEVGANTAIVSLVQMMRVL LVVLSIPFLVILIYTKQDRTASAAAETISSATTDFRLAPVLWTVILILAAWGACKAAK FLKFPAPWLLGSMLGVAIVHVGGAAVTGHDMTAWWLSQANHVSQVFLGATIGSKMYKS MFAGVTRIIIVGFVSSVGLIAAMFLSAVIVSELTGISLITSVLAFAPGGIAEMATTSV TLHADSTFVVAVQVIRVILVIALLPPFYRLLHHLHGEKKDKKSSISGSSA*" /label="yhjN CDS" gene complement(1027299..1028453) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /label="yhjN gene" S_feature complement(1028454..1028525) /Source="Nicolas_S_feature" /locus_tag="new_1132073_1132144_c" /HighExp="Cold, GM 15, GM 10, dia15, BC, BI, Salt, B60, Sw, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S377" promotor_-10 complement(1028508..1028527) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1028524) /Source="Nicolas_upshifts" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1028541..1028546) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1028560..1029765) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease (recent HGT island)" /protein_id="NP_388939.1" /db_xref="EnsemblGenomes-Gn:BSU10580" /db_xref="EnsemblGenomes-Tr:CAB12898" /db_xref="GOA:O07569" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13081" /db_xref="UniProtKB/Swiss-Prot:O07569" /translation="MLTSFHSIKSRYTAPVRLRFFGELLTSLTGAMMGPFMVLYLHEQ LNGSIMMPMLIISLQPFADIFLTLAAGRVTDRLGRRTAILTALLLQSAAMTGFVFAEH AYVFAILYVMNGIGRSLYIPASRAQIAESTPESRRSEVFAVINAIYSTGLTAGPLVGM LLYNHNPVWIFALDAAALFIYFLIAALKLPETKPLHPAVTPKMSASFTIYRPVLLLLL LSLPISMLYAQTETTYRLFSKNMFSDYLSMLTIYSAAKALFSCVLQVPLVKGTEKLSM KTILFITYICYSLAAAGFACSTSLTMLLVTAAVMTVGESIGLTHIQTFISKLAPPHLL GRFYAVYGLHWDISRSIGPLAGGLILTSFGGEVIFYALAVCLLTAGLSLTYTIEKLEH KVIRKVNRL*" /label="yhjO CDS" gene complement(1028560..1029765) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /label="yhjO gene" misc_feature 1029786..1029805 /Source="Nicolas_upshift_promotors" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1029791 /Source="Nicolas_upshifts" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1029879..1031606 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcription factor" /protein_id="NP_388940.1" /db_xref="EnsemblGenomes-Gn:BSU10590" /db_xref="EnsemblGenomes-Tr:CAB12899" /db_xref="GOA:O07570" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR025370" /db_xref="InterPro:IPR030678" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13082" /db_xref="UniProtKB/Swiss-Prot:O07570" /translation="MKLIEHYVALVKTGCAEYGQMNEMTLTEIADCLFCTERNAKLIL HKLENSNWIIRESGAGRGRKSKIAFLRRPEELLLQTAKEYTMSGKLKKAKELLQQYQS AFPGLQNEYNMWLSEVFGFVTETGENGAKDVLRLFITPESVSSLDPCQIFLRSEGHFV KQIFDTLFTFDSDMQEPKPHLVHGWEEVGKKQWRFFLRKGVLFHNGQPLTSRDVAFTF QRFLELADNPYKWLLHGVKQVLEKGPYCVELILDKPNALLPYALCDERLSILPAEQGG GKNGTGPFQMNQQHSGMLVLEANERYFKGRPYLDRVEFVFSEQAGEMNGFTIQEKQTC PEQQTVFDERHVQYLSLNLKKKGPLQHRSFRKALRLLISSERLVREAGGHRRIPVTSF LHPSPFEWEGVSPSELLKKSGYEGETIVLYTFSETDHREDAEWIQNICAQHGIRLTLQ FCDAADLRRPEIVQMADIIHDSATFYQDSEFGFLHLLLSENSFLYQHLSEKLTQICSG MTERMFSMPDRCSRINILRDIDRQMIQELNAIPLYQNVLQVTSSKNVKGLVLDEEGWI DLYSVWLSK*" /label="yhjP CDS" gene 1029879..1031606 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /label="yhjP gene" promotor_-35 1031192..1031199 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1031214..1031233 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1031221 /Source="Nicolas_upshifts" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1031636..1031962) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12625841; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative metal-chelating cysteine-rich protein of unknown function" /protein_id="NP_388941.1" /db_xref="EnsemblGenomes-Gn:BSU10600" /db_xref="EnsemblGenomes-Tr:CAB12900" /db_xref="InterPro:IPR005560" /db_xref="PDB:5FIG" /db_xref="SubtiList:BG13083" /db_xref="UniProtKB/Swiss-Prot:O07571" /translation="MEQYSEACIEACIDCMKACNHCFTKCLEESVQHHLSGCIRLDRE CADICALAVKAMQTDSPFMKEICALCADICEACGTECGKHDHDHCQACAKACFTCAEQ CRSMAA*" /label="yhjQ CDS" gene complement(1031636..1031962) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /label="yhjQ gene" CDS complement(1032080..1032517) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22078549, 22882546; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative electron carrier protein (putative sporulation gene)" /protein_id="NP_388942.1" /db_xref="EnsemblGenomes-Gn:BSU10610" /db_xref="EnsemblGenomes-Tr:CAB12901" /db_xref="GOA:O07572" /db_xref="InterPro:IPR003251" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13084" /db_xref="UniProtKB/Swiss-Prot:O07572" /translation="MHYSYYPYPVPYREDPVLIRNLQKAINGEFSAIQCYRKLAELAH SDEVRKQIEEIRRDEIRHLREFSTLYGSITGKHIMPKQTEECPDNFTRGLDAAFKDEQ ETVDFYLRAAEETSNLKAKGVFTRAARDEQNHAVWFLYYLMER*" /label="yhjR CDS" gene complement(1032080..1032517) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /label="yhjR gene" downshifts complement(1032089) /Source="Nicolas_upshifts" /id="D578" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.72767" /MaxDrop="3.86885" /score="16.2430017" /energy="-11.5" /TU="U859" /idTUdmin="U859" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1032548..1032567) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1032568) /Source="Nicolas_upshifts" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1032580..1032589) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1032637..1032644 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1032658..1032677 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1032670 /Source="Nicolas_upshifts" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="upshifts" CDS 1032701..1036201 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit B)" /protein_id="NP_388943.2" /db_xref="EnsemblGenomes-Gn:BSU10620" /db_xref="EnsemblGenomes-Tr:CAB12902" /db_xref="GOA:P23477" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014140" /db_xref="InterPro:IPR027417" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10465" /db_xref="UniProtKB/Swiss-Prot:P23477" /translation="MGAEFLVGRSGSGKTKLIINSIQDELRRAPFGKPIIFLVPDQMT FLMEYELAKTPDMGGMIRAQVFSFSRLAWRVLQHTGGMSRPFLTSTGVQMLLRKLIEE HKQEFKVYQKASDKSGFTAQVERMLTEFKRYCLEPEDIRRMAESGTASEYRGERVLSE KLHDLSILYQQMEKSLADQYLHSEDYLTLLAEHIPLAEDIKGAHIYVDGFYQFTPQEF RVLEQLMVHAEHITFSLTADKPSYEREPHELELFRMTGKTYYRLHQKAKELNLDITYK ELSGTERHTKTPELAHLEAQYEARPAIPYAEKQEALTVMQAANRRAELEGIAREIHAL VREKGYRYKDVAILARQPEDYKDMVKEVFADYEIPYFIDGKASMLNHPLIEFIRSSLD VLKGNWRYEAVFRCVKTELLFPLNEPKAKVREQVDQLENYCIAYGIKGDRWTKGDRFQ YRRFVSLDDDFAQTDQEIEMENMLNDTRDWIVPPLFQLQKRMKKAKTVQEKAEALYRY LEETDVPLKLDQERQRAEDDGRIIEAQQHQQAWDAVIQLLEEFVEMMGDDEISLDLFQ QMIEAGAESLTFSLIPPALDQVFVGNMDLSRMYGTSCTFVLGANDGVLPARPDENGVL SDDDREWLKTIGVELSSGGRERLLDEHFLIYMAFSSPSDRLYVSYPIADAEGKTLLPS MIVKRLEELFPHHKERLLTNEPEQVSDEEQLMYVVNKSVAQSFTASQLRLWTREYDIS DVWWSTYNVLMSEQDRLQSKKLFSSLFFRNEVKQLERSVSRQLYGERIQGSVSRMETF NACPFSHFASHGLHLKERQFFKLEAPDIGQLFHSSLKLISDRLREQKLDWRDLTKEQC ELFSYDAVERLAPKLQKEILLSSNRHYYVKEKLQKIVTRVSGILSEHAKASGFVPIGL ELGFGGKGPLPPLTFQLKNGCTMELVGRIDRVDKAESSKGLLLRIVDYKSSDKGLDLA EVYYGLALQMLTYLDLSITHSADWLGMRATPAGVLYFHIHDPMIQSNLPLGLDEIEQE IFKKFKMKGLLLGDQEVVRLMDTTLQEGRSNIINAGLKKDGSLRSDSAAVGEKEFDLL TKHVRRTFQEAGEQITDGRVSIEPYKMKNKTPCTYCAFKSVCQFDESLEENEYRPLKA EKDKTILEWIKKEADGNEHS*" /label="addB CDS" gene 1032701..1036201 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /label="addB gene" CDS 1036188..1039886 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit A)" /protein_id="NP_388944.2" /db_xref="EnsemblGenomes-Gn:BSU10630" /db_xref="EnsemblGenomes-Tr:CAB12903" /db_xref="GOA:P23478" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR011335" /db_xref="InterPro:IPR011604" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014152" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10466" /db_xref="UniProtKB/Swiss-Prot:P23478" /translation="MNIPKPADSTWTDDQWNAIVSTGQDILVAAAAGSGKTAVLVERM IRKITAEENPIDVDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLN RASISTLHSFCLQVLKKYYYLIDLDPGFRIADQTEGELIGDEVLDELFEDEYAKGEKA FFELVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEELPF YQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSE LYKRVPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTDYFTRSPEQHLKS LAEMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAILTAENDKGEREPSE AARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAE PLLFLSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQ AELKLGAAYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSP FKVYDGKKKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTSGYFEAVEVA VALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRLENKKAPYYEAMKDYLAAGD RSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVGGMPGGKQRQANL RVLYDRARQYESTAFRGLFRFLRFIERMQERGDDLGTARALSEQEDVVRLMTIHSSKG LEFPVVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMR RELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQAR TYLDFIGPALARHRDLGDLAGVPAHADISGHPARFAVQMIHSYDLLDDDLEERMEEKS ERLEAIRRGEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTKQSVSEIKRKREYEDEYS GRAPVKPADGSILYRRPAFMMKKGLTAAEKGTAMHTVMQHIPLSHVPSIEEAEQTVHR LYEKELLTEEQKDAIDIEEIVQFFHTEIGGQLIGAKWKDREIPFSLALPAKEIYPDAH EADEPLLVQGIIDCLYETEDGLYLLDYKSDRIEGKFQHGFEGAAPILKKRYETQIQLY TKAVEQIAKTKVKGCALYFFDGGHILTL*" /label="addA CDS" gene 1036188..1039886 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /label="addA gene" S_feature 1039887..1039957 /Source="Nicolas_S_feature" /locus_tag="new_1143506_1143576" /HighExp="H2O2, C90, Heat, LBGtran, dia15, HiTm, Diami, C30, Lbtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S378" CDS 1039958..1041133 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7968921, 8493111, 16780573" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7968921, 8493111, 16780573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair exonuclease" /protein_id="NP_388945.3" /db_xref="EnsemblGenomes-Gn:BSU10640" /db_xref="EnsemblGenomes-Tr:CAB12904" /db_xref="GOA:P23479" /db_xref="InterPro:IPR004593" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR026843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG10467" /db_xref="UniProtKB/Swiss-Prot:P23479" /translation="MRILHTADWHLGKTLEGRSRLSEQADVLDELNTIVKDEQIDAIV MAGDAFDTVNPPALAEQLFYESLSALSDRGKRPIVVIAGNHDNPDRLSAASPLTHENG IHLIGYPTTEPIHIEVPSAGELLAVGALAYPSEARLNEVLSDTFDEKLLRDHYDVKIR QAFEHMTSRFRTDAVKIAASHIYVAGGNQTDSERPIEVGGAYTVAAESLPADAAYVAL GHLHRPQTIKRARTLARYSGSPLAYSFSEAGYAKSVTIVDAKPGEEATWQEVLLSSGK PLVKWKAANGLSEVYSWLDEGRDQNAWIDLEIRVADQLSLEEIHRLRKAHPGFIHIRP VFEEQNKDRERIEVKHVSIEDRFKKFYEKQTGGAVPDEEMVKLFLELASGVEEEDAK* " /label="sbcD CDS" gene 1039958..1041133 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /label="sbcD gene" CDS 1041130..1044522 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 19906728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 19906728; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ATP-dependent repair enzyme" /protein_id="NP_388946.2" /db_xref="EnsemblGenomes-Gn:BSU10650" /db_xref="EnsemblGenomes-Tr:CAB12905" /db_xref="GOA:O06714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13088" /db_xref="UniProtKB/Swiss-Prot:O06714" /translation="MKPIALSIKGLHSFREEQTIDFEGLSGAGVFGIFGPTGSGKSSI LDAMTLALYGKVERAANNTHGILNHAEDTLSVSFTFALQTNHQISYKVERVFKRTDEM KVKTALCRFIEIKDEHTVLADKASEVNKRVEELLGLTIDDFTRAVVLPQGKFAEFLSL KGAERRHMLQRLFNLEQYGDRLVKKLRRQAQEANARKNEMLAEQSGLGEASSEAVEQA EKVLEQAEARLEAMRKNRDQAKERFTEHQEIWNVQKEKSTYEEEEKRLAEEQPHIDSM QKRLLEAETAAALKPYADRYAEAIQHEEQAEKEQTLAQKDLADRTAFFQQKHEEYEAW RQHKSEKEPELLAKQEQLSRLQEIEIKLSEAKQEEERKKADLRQKEEALQSVMNELET VTDRLTRGQNRQTELKQQLKSLQVTSDERKSCQQAAEMALRIRQTEEQIKKEKKRSEE LNLVLQKMNEEKNTLVQKTEAEENNIIQAYEAVQTVYHLVCETERSLTRMTEEARKSQ HTLHLQREKARVALLTKELAQKLTAGKPCPVCGSTDHDPSASVHETYEADSHLEEDIK RTDVLLTEAAALSQEILSAKIMLEEQSARFIEQCPFLQTIQAQNLEAAASFEHQPVYE AFETAKFEWKRIKQDILSVKTRMAQMIGAYQESLKKAEQLNEKIGFEKREADRIESII SELQSSMDSSLNMFKEAFQNQSVDEAEKWQQAIEEKDRAAEECEKRIEKSIAFLAEHE AQKEKLRESGHRLEREKLELHYAAERIKSVIADYEHELGDYAKGDSIQIKLRSVQQDL KLLKEKEQSLYEELQSAQMKLNQAKSRASASELTLQEAKGRLEKAKAAWLEHTKNTSI TRTEEVEQSLIPADELEKMKTGIDQFMDKLKQNAANLKRVAEILAGRALSESEWNETV AALQEAEDAFGAAIEEKGAAAKALAVIRDHHKRFNEIEAELKKWQMHIDRLDKLQAVF KGNTFVEFLAEEQLESVARDASARLSMLTRQRYAIEVDSEGGFVMRDDANGGVRRPVS SLSGGETFLTSLSLALALSAQIQLRGEYPLQFFFLDEGFGTLDQDLLDTVVTALEKLQ SDNLAVGVISHVQELRARLPKKLIVHPAEPSGRGTRVSLELM*" /label="sbcC CDS" gene 1041130..1044522 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /label="sbcC gene" promotor_-35 1043777..1043783 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1043798..1043809 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1043805 /Source="Nicolas_upshifts" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1043874..1044847) /Source="Nicolas_S_feature" /locus_tag="new_1147493_1148466_c" /HighExp="S6, S8, S7, BT, C30, B36, S5, C90, Pyr, B60" /AntisenseName="yisB" /AntisenseCor="0.19649597897587401" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S379" CDS 1044536..1044838 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 22984257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 22984257; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="HNH nuclease-like essential for DNA repair" /protein_id="NP_388947.1" /db_xref="EnsemblGenomes-Gn:BSU10660" /db_xref="EnsemblGenomes-Tr:CAB12906" /db_xref="SubtiList:BG13089" /db_xref="UniProtKB/Swiss-Prot:O06715" /translation="MAKQIAGICELCGRSDVQLTEHHLTPKEEGGTFLPTAMLCIPCH KQIHALYTNQELAVRLNGMAELRSDPELARFVKWIRKQPPEKLIKTKKSNERKKKK*" /label="hlpB CDS" gene 1044536..1044838 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /label="hlpB gene" downshifts 1044818 /Source="Nicolas_upshifts" /id="D579" /incds=0 /nref=230 /ntot=269 /MaxReadThrough="1.42126" /MaxDrop="6.71114" /score="0.317490594" /energy="-14.3" /TU="NA" /idTUdmin="U861" /TUdmin=1 /isTUend="TRUE" /label="downshifts" downshifts complement(1044892) /Source="Nicolas_upshifts" /id="D580" /incds=0 /nref=40 /ntot=66 /MaxReadThrough="3.93344" /MaxDrop="5.39228" /score="13.5435041" /energy="-15.3" /TU="U863" /idTUdmin="U863" /TUdmin="-989" /isTUend="FALSE" /label="downshifts" SCAR 1044896..1044897 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs27_007" downshifts 1044916 /Source="Nicolas_upshifts" /id="D586" /incds=0 /nref=239 /ntot=267 /MaxReadThrough="1.55031" /MaxDrop="8.31576" /score="36.3638154" /energy="-12.3" /TU="NA" /idTUdmin="U868" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1044955..1045542) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388959.1" /db_xref="EnsemblGenomes-Gn:BSU10780" /db_xref="EnsemblGenomes-Tr:CAB12918" /db_xref="InterPro:IPR024488" /db_xref="SubtiList:BG12239" /db_xref="UniProtKB/Swiss-Prot:O06727" /translation="MKKKETAWMKRKQLLYTEERKWEYGTILIEDGICLIENGEGDIL LADSLQHSPIWIHHKGKWEQAGFQDKLVLACGAENISLSGGERIRYEKSVKRPLMALL DSLDDETFLAFLQHLHSFGLSVFDCVFSYNKGVFSNTSAGQGVSFYHFSNDTAQCAMQ HHYNYSSEGTGDRFEWTASNGKRSIMYTAVQRGRK*" /label="yisN CDS" gene complement(1044955..1045542) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /label="yisN gene" promotor_-10 complement(1045557..1045576) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1045576) /Source="Nicolas_upshifts" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1045592..1045594) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1045597..1045603 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1045615 /Source="Nicolas_upshifts" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1045618..1045636 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1045621..1045687 /Source="Nicolas_S_feature" /locus_tag="new_1157170_1157236" /HighExp="S6, S5, S7, S8, B36, S4, BT, G/S, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S387" CDS 1045688..1047532 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /EC_number="6.3.5.4" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (sporulation related)" /protein_id="NP_388960.2" /db_xref="EnsemblGenomes-Gn:BSU10790" /db_xref="EnsemblGenomes-Tr:CAB12919" /db_xref="GOA:O05272" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG12240" /db_xref="UniProtKB/Swiss-Prot:O05272" /translation="MCGITGWVDFKKQLVQEKQTMDRMTDTLSKRGPDDSNVWGEHHV LFGHKRLAVVDIEGGRQPMACTYKGDTYTIIYNGELYNTEDLRKELRARGHQFERTSD TEVLLHSYIEWQEDCVDHLNGIFAFAVWDEKRNLLFAARDRLGVKPFFYTKEGSSFLF GSEIKAILAHPDIKARVDRTGLSEIFGLGPSRTPGTGIFKGIKEIRPAHALTFSKDGL NIWRYWNVESEKHTDSFDDTVANVRSLFQDAVTRQLVSDVPVCTFLSGGLDSSAITAI AAGHFEKEGKAPLHTYSIDYEENDKYFQASAFQPNDDGPWIEKMTEAFGTTHHKCVIS QKDLVDHLEEAVLVKDLPGMADVDSSLLWFCREIKKDFVVSLSGECADEIFGGYPWFH TADVESGFPWMRSTEERIKLLSDSWQKKLNLKEYVNAKYEETLAETPLLDGETGVDKA RRQLFYLNMLWFMTNLLDRKDRMSMGASLEVRVPFADHRLVEYVWNIPWEMKMHDNRE KGILRKALEGILPDDILYRKKSPYPKTHHPEYTKGVSEWLKTIRSQKDSVLHTLLDRK QLDQLLETEGSSFKVPWFGQLMKGPQLIAHLAQIHTWFEAYRIDIDER*" /label="asnO CDS" gene 1045688..1047532 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /label="asnO gene" S_feature 1047533..1047600 /Source="Nicolas_S_feature" /locus_tag="new_1159082_1159149" /HighExp="S6, S5, S7, B36, BT, S8, S4, B60, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S388" downshifts 1047557 /Source="Nicolas_upshifts" /id="D587" /incds=0 /nref=12 /ntot=43 /MaxReadThrough="3.29969" /MaxDrop="4.67478" /score="3.55879494" /energy="-14.8" /TU="U870" /idTUdmin="U870" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1047662..1048141) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation related)" /protein_id="YP_054576.1" /db_xref="EnsemblGenomes-Gn:BSU10800" /db_xref="EnsemblGenomes-Tr:CAE01451" /db_xref="GOA:Q7WY73" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="PDB:2QE9" /db_xref="SubtiList:BG14187" /db_xref="UniProtKB/Swiss-Prot:Q7WY73" /translation="MMKFFEYNWQVRDQWFTWCHQLTTEELLKNRLGGVENILYTLFH IIDVEYSWIRAIQGKEDIAVQFADYQTLNKVKSLSNTFRTEIIDVLQTHSDQIKDELV SVPWETGVLYTRDEILHHIIAHEIHHIGQLSVWARELKLSPVSASFIGRTLKPIHSY* " /label="yizA CDS" gene complement(1047662..1048141) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /label="yizA gene" upshifts complement(1048161) /Source="Nicolas_upshifts" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1048165..1048183) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1048194..1048202) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1048333..1048337 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1048350 /Source="Nicolas_upshifts" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1048352..1048371 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1048373..1049197 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /EC_number="3.6.1.27" /experiment="publication(s) with functional evidences, PMID:23295493, 25308276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23295493, 25308276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate phosphatase" /protein_id="NP_388961.1" /db_xref="EnsemblGenomes-Gn:BSU10810" /db_xref="EnsemblGenomes-Tr:CAB12920" /db_xref="GOA:O06728" /db_xref="InterPro:IPR002060" /db_xref="InterPro:IPR008949" /db_xref="PDB:3WE9" /db_xref="SubtiList:BG12241" /db_xref="UniProtKB/Swiss-Prot:O06728" /translation="MIHRSEKMKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQAS WAVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGKQHLWKAFDHAYRTFTLESEPFR EFIAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQ LVRFLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEE CQDALPLFPQYSQKTVKAALHLHRAVLEKIRAKQHDVFQYHFALTETEVKQILSDI*" /label="farP CDS" gene 1048373..1049197 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /label="farP gene" promotor_-35 1048585..1048591 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1048606..1048624 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1048613 /Source="Nicolas_upshifts" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1049207..1050657 /Source="Nicolas_S_feature" /locus_tag="new_1160756_1162206" /HighExp="Salt, Etha, Sw, Cold, G150, G180, G135, LBGtran, Heat, Paraq" /AntisenseName="yisQ" /AntisenseCor="0.19511630802652" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S389" CDS complement(1049227..1050594) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na(+)-driven efflux transporter" /protein_id="NP_388962.1" /db_xref="EnsemblGenomes-Gn:BSU10820" /db_xref="EnsemblGenomes-Tr:CAB12921" /db_xref="GOA:O07940" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG12242" /db_xref="UniProtKB/Swiss-Prot:O07940" /translation="MKQAVFKSTALKKPADKTFSLFSLTWPIFIEVSLYMFMGNADTL MLSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTVIISQFLGSRQKKEAMEVAYVSI GANFFISLAISAVVFFAAVPLLHMMGLSDALMPDAKVFLQVVGGLSFIQALIMTFSAI LKSYGYTKDTMFVTIGMNILNIAGNFVVIFGLFGFPVLGVAGVAMSTSIARVIGLIAM IVIVNKRIQLKMSLKKVFHMHKEHLRKLLKIGIPSAGEQLSYNLSQMIVTYFIAIMGA QALTTKVYTQNITMFILLFGTAISQGTQILIGRYIGGKQFDAAYERCMKSLYWALGIA AATSVLMTIFSKDLIGLFTQSPDIIATASLLIAMTIILEPGRSFNVIIINSLRAAGDA KFPVYMAMISMWGIGLPLAYLFGIHLGFGLAGIWISFIADEWVRGILMYRRWRSRIWI QKGMA*" /label="yisQ CDS" gene complement(1049227..1050594) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /label="yisQ gene" promotor_-35 1050626..1050633 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1050647..1050666 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1050659 /Source="Nicolas_upshifts" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="upshifts" CDS 1050718..1051581 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388963.1" /db_xref="EnsemblGenomes-Gn:BSU10830" /db_xref="EnsemblGenomes-Tr:CAB12922" /db_xref="GOA:P40331" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11064" /db_xref="UniProtKB/Swiss-Prot:P40331" /translation="MPRILFTVPPFPVFIAAGEGVFKKGETHVKRVFSVFDLIYVKQG TLYITENETSFSVEGGEYILLSPGLEHYGTKGSDEATSYYWLHFDEHRYEFTAKGGSN WSELQQEKGSFEELARYGLALPRKGKVQRPQFMAQQFEKLIDYSAENSDLPLRKQILF EELMLHLQKEAFQIPSAKERVAWEAARYLQEHYKEKTTIKDLSLALHYHQDYVSRCMQ QVLGVTPAQYTNRVRMTEAKRLLSSTNDKMGVIAETVGMEDPTYFSKLFKQIEGISPI EYRKIVSRKVQ*" /label="yisR CDS" gene 1050718..1051581 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /label="yisR gene" CDS 1051599..1052612 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8407808, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8407808, 23504016, 28693424; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of iolX (LacI family)" /protein_id="NP_388964.1" /db_xref="EnsemblGenomes-Gn:BSU10840" /db_xref="EnsemblGenomes-Tr:CAB12923" /db_xref="GOA:P37947" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10847" /db_xref="UniProtKB/Swiss-Prot:P37947" /translation="MKTTIYDVAKAAGVSITTVSRVINNTGRISDKTRQKVMNVMNEM AYTPNVHAAALTGKRTNMIALVAPDISNPFYGELAKSIEERADELGFQMLICSTDYDP KKETKYFSVLKQKKVDGIIFATGIESHDSMSALEEIASEQIPIAMISQDKPLLPMDIV VIDDVRGGYEAAKHLLSLGHTNIACIIGDGSTTGEKNRIKGFRQAMEEAGVPIDESLI IQTRFSLESGKEEAGKLLDRNAPTAIFAFNDVLACAAIQAARIRGIKVPDDLSIIGFD NTILAEMAAPPLTTVAQPIKEMGRSVIELLAEAIEGKRKAKQKIVLPPELVVRHSTSP LNT*" /label="iolQ CDS" gene 1051599..1052612 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /label="iolQ gene" downshifts 1052595 /Source="Nicolas_upshifts" /id="D588" /incds=0 /nref=13 /ntot=204 /MaxReadThrough="0.51227" /MaxDrop="3.29173" /score="25.1260914" /energy="-9.6" /TU="NA" /idTUdmin="U874" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-35 1052664..1052671 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1052686..1052705 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1052705..1052820 /Source="Nicolas_S_feature" /locus_tag="new_1164254_1164369" /HighExp="Lbstat, M40t90, M0t90, BI, G150, dia0, Mt0, Lbexp, Lbtran, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S390" upshifts 1052705 /Source="Nicolas_upshifts" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="upshifts" CDS 1052821..1053849 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /EC_number="1.1.1.370" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11160890, 20133360, 23109554, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 20133360, 23109554, 23504016, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NAD(+))" /protein_id="NP_388965.1" /db_xref="EnsemblGenomes-Gn:BSU10850" /db_xref="EnsemblGenomes-Tr:CAB12924" /db_xref="GOA:P40332" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11065" /db_xref="UniProtKB/Swiss-Prot:P40332" /translation="MEHQVRCAVLGLGRLGYYHAKNLVTSVPGAKLVCVGDPLKGRAE QVARELGIEKWSEDPYEVLEDPGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTL SLEESKAASEKVKETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGA PPAEFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALT YIEFDSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDII PDFQTRFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRNGMPVQLD VKRAYTGM*" /label="iolX CDS" gene 1052821..1053849 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /label="iolX gene" downshifts 1053871 /Source="Nicolas_upshifts" /id="D589" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="0.33001" /MaxDrop="3.45406" /score="8.69111487" /energy="-13.4" /TU="NA" /idTUdmin="U875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1053900..1054409) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25651892; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative enzyme regulator of activity" /protein_id="NP_388966.2" /db_xref="EnsemblGenomes-Gn:BSU10860" /db_xref="EnsemblGenomes-Tr:CAB12925" /db_xref="GOA:O07939" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12243" /db_xref="UniProtKB/Swiss-Prot:O07939" /translation="MTDAKQFYDYHSWANKKIFTHIENLPEETAYQEVKSVFPSVSDV LLHMCRADYIWLNVLSGVAYQEIIDSAGKLQSAQGNMAAIKQHAAELESQYHDFFSRQ TDLEQTFTMQHPKLGTLESTYADTILHVVNHGTYHRGNVTAMLRQLDHSGVPTDYMYY LYEKRESKG*" /label="yisT CDS" gene complement(1053900..1054409) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /label="yisT gene" downshifts complement(1053919) /Source="Nicolas_upshifts" /id="D590" /incds=0 /nref=81 /ntot=251 /MaxReadThrough="-0.0416600000000003" /MaxDrop="7.15629" /score="27.2292301" /energy="-13.4" /TU="NA" /idTUdmin="U876" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1054422..1054440) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1054438) /Source="Nicolas_upshifts" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1054452..1054460) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1054459..1055121) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid related metabolite efflux transporter" /protein_id="NP_388967.1" /db_xref="EnsemblGenomes-Gn:BSU10870" /db_xref="EnsemblGenomes-Tr:CAB12926" /db_xref="GOA:O06730" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG13100" /db_xref="UniProtKB/Swiss-Prot:O06730" /translation="MTISLMIEKKCERSFFSMNAIIHGIVLAFGLILPLGVQNVFIFQ QGALQKHIWRALPAVISASVCDTLLIVLAVAGVSVIVQELPVFETVMMAGGFLFLLYM GWVTWNIRPNTSQNEKHTFTPKKQAAFAAAVSLLNPHAILDTIGVIGTSSLQYSGLEK WLFMAACIAVSWIWFISLAIAGRLFQTIDTSGRLMLIVNKCSAAVMWAAAGYFGVSLF CN*" /label="yisU CDS" gene complement(1054459..1055121) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /label="yisU gene" promotor_-35 1055140..1055146 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1055160..1055179 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1055169 /Source="Nicolas_upshifts" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="upshifts" CDS 1055188..1056642 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 19383706; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388968.2" /db_xref="EnsemblGenomes-Gn:BSU10880" /db_xref="EnsemblGenomes-Tr:CAB12927" /db_xref="GOA:Q796Q6" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13101" /db_xref="UniProtKB/Swiss-Prot:Q796Q6" /translation="MTLSQWQPSRKSDVPLHRQIEQYMKDKILHGEWAVGTKIPSQRT LADMFQVNRSTVTAAIDELTSQGLLEGRKGGGTKVVNSTWSVLTAEPPLDWSDYVRSG IHRANSSIIQAINQNEPRADIIRLGTGELSPDLVPADTIGRMFQQINPGVLSLGYEQP KGNRQLREAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYL QSLHVFQSAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQR RKEIISLSKKEQMPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGAFSKTVSPGLR IGWLAGPEPVIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRD AAVHFLERYAGDIATWRIPAGGFYIWVTFHKNLPVSRFFYELLKRQVLVNPGYIYDGE DRNSIRLSYSYASLGDLETGIKAAAETARRLMMS*" /label="yisV CDS" gene 1055188..1056642 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /label="yisV gene" S_feature complement(1056497..1056649) /Source="Nicolas_S_feature" /locus_tag="new_1168046_1168198_c" /HighExp="Diami, Sw, C90, LBGstat, dia15, Paraq, dia5, BC, M40t45, Oxctl" /AntisenseName="yisV" /AntisenseCor="0.69858995161852" /AntisenseRegPval="-40" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S391" downshifts complement(1056532) /Source="Nicolas_upshifts" /id="D591" /incds=1 /nref=2 /ntot=84 /MaxReadThrough="2.36735" /MaxDrop="2.81041" /score="-5.131548" /energy="-17.3" /TU="NA" /idTUdmin="U879" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1056650..1057288) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388970.1" /db_xref="EnsemblGenomes-Gn:BSU10890" /db_xref="EnsemblGenomes-Tr:CAB12929" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG13103" /db_xref="UniProtKB/Swiss-Prot:O06733" /translation="MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGED IERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVG MNVAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSDTVLQQTHFDGCEL EGASFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV*" /label="yisX CDS" gene complement(1056650..1057288) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /label="yisX gene" S_feature complement(1057289..1057423) /Source="Nicolas_S_feature" /locus_tag="new_1168838_1168972_c" /HighExp="Diami, dia15, dia5, C90, BC, Paraq, LBGstat, Lbtran, HiOs, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S392" promotor_-35 1057337..1057342 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1057358..1057376 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1057359 /Source="Nicolas_upshifts" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="upshifts" S_feature 1057369..1057493 /Source="Nicolas_S_feature" /locus_tag="new_1168918_1169042" /HighExp="S6, S5, S8, S7, S4, BT, B36, S3, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S393" promotor_-10 complement(1057409..1057428) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1057423) /Source="Nicolas_upshifts" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1057443..1057450) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1057494..1058300 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl hydrolase or peroxidase" /protein_id="NP_388971.1" /db_xref="EnsemblGenomes-Gn:BSU10900" /db_xref="EnsemblGenomes-Tr:CAB12930" /db_xref="GOA:O06734" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13104" /db_xref="UniProtKB/Swiss-Prot:O06734" /translation="MGHYIKTEEHVTLFVEDIGHGRPIIFLHGWPLNHKMFEYQMNEL PKRGFRFIGVDLRGYGQSDRPWEGYDYDTMADDVKAVIYTLQLENAILAGFSMGGAIA IRYMARHEGADVDKLILLSAAAPAFTKRPGYPYGMRKQDIDDMIELFKADRPKTLADL GKQFFEKKVSPELRQWFLNLMLEASSYGTIHSGIALRDEDLRKELAAIKVPTLILHGR KDRIAPFDFAKELKRGIKQSELVPFANSGHGAFYEEKEKINSLIAQFSNS*" /label="yisY CDS" gene 1057494..1058300 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /label="yisY gene" downshifts 1058293 /Source="Nicolas_upshifts" /id="D592" /incds=0 /nref=4 /ntot=24 /MaxReadThrough="2.64682" /MaxDrop="5.60718" /score="8.70914085" /energy="-6.5" /TU="NA" /idTUdmin="U878" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1058328..1058927) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /EC_number="2.7.1.25" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenylylsulfate kinase" /protein_id="NP_388972.1" /db_xref="EnsemblGenomes-Gn:BSU10910" /db_xref="EnsemblGenomes-Tr:CAB12931" /db_xref="GOA:O06735" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13105" /db_xref="UniProtKB/Swiss-Prot:O06735" /translation="MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLA NAVDEKLYRKGIQSYVLDGDNIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMI LTAFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKGLYKKARNGEIKHFTG IDSPYEAPLSPDFIIESDQTSISDGADLIINALQNRGII*" /label="yisZ CDS" gene complement(1058328..1058927) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /label="yisZ gene" downshifts complement(1058347) /Source="Nicolas_upshifts" /id="D593" /incds=0 /nref=35 /ntot=44 /MaxReadThrough="1.69999" /MaxDrop="6.8011" /score="17.1506785" /energy="-7.3" /TU="NA" /idTUdmin="U880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1058924..1060093) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /EC_number="2.7.7.4" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfate adenylyltransferase" /protein_id="NP_388973.2" /db_xref="EnsemblGenomes-Gn:BSU10920" /db_xref="EnsemblGenomes-Tr:CAB12932" /db_xref="GOA:O06736" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13106" /db_xref="UniProtKB/Swiss-Prot:O06736" /translation="MNGNEPHGGVLINRCDPACHFEGCACQAELDQLALSDLELIAIG GYSPLTGFLGEKDYHSVVKEMRLANGLPWSLPITLPVGEKTARQLSAGDHVKLVKDGV TYGMITVTDIYQPDKTQEALSVFKTNDPAHPGVKKLLARPDYYIGGPITVSSLPDKSF EQFYATPAETRAAFQKLGWKTIVGFQTRNPVHRAHEYIQKTALETVDGLLLHPLVGET KSDDIPSDIRMESYQALLNHYYPKDRVMLSVFPAAMRYAGPREAIFHALVRKNYGCTH FIVGRDHAGVGSYYGTYDAQNIFQSFTEEELGIKPLFFEHSFYCRKCGNMGTSKTCPH SPRDHIHLSGTKVRELLRQGKKPPKEFSRPEVAAVLIKGLHQQPVAIKQNSGELQ*" /label="yitA CDS" gene complement(1058924..1060093) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /label="yitA gene" S_feature complement(1060094..1060205) /Source="Nicolas_S_feature" /locus_tag="new_1171643_1171754_c" /HighExp="S6, S7, S8, BT, S5, B36, G/S, Pyr, SMMPr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S394" CDS complement(1060206..1060916) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospho-adenylylsulfate reductase" /protein_id="NP_388974.2" /db_xref="EnsemblGenomes-Gn:BSU10930" /db_xref="EnsemblGenomes-Tr:CAB12933" /db_xref="GOA:O06737" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13107" /db_xref="UniProtKB/Swiss-Prot:O06737" /translation="MNETITYDTWNDMLSKQITDQLIDELDVLKWAYRTYGEKIVYAC SFGAEGMVLLDLISKINKNAHIIFLDTGLHFQETYELIETVKERYPGFAIQMLEPELS LTEQGTKYGGELWKHNPNLCCQLRKIEPLKKHLSGMTAWISGLRRDQSPTRKHIQYVN LDQKFELIKICPLIHWTWDDVWTYIRLHNLPYNKLHDQHYPSIGCEMCTLPSPDPNDE RAGRWAGREKTECGLHQE*" /label="yitB CDS" gene complement(1060206..1060916) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /label="yitB gene" promotor_-10 complement(1060960..1060979) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1060982) /Source="Nicolas_upshifts" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1060992..1061001) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1061031..1061040 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1061054..1061073 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1061065 /Source="Nicolas_upshifts" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="upshifts" CDS 1061101..1061787 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /EC_number="3.1.3.71" /function="15.7: Sporulation and germination" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3346220, 11830598, 15383836, 16341843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho,3-sulfolactate phosphatase (sporulation related)" /protein_id="NP_388975.1" /db_xref="EnsemblGenomes-Gn:BSU10940" /db_xref="EnsemblGenomes-Tr:CAB12934" /db_xref="GOA:O06738" /db_xref="InterPro:IPR005238" /db_xref="InterPro:IPR036702" /db_xref="SubtiList:BG13108" /db_xref="UniProtKB/Swiss-Prot:O06738" /translation="MPIAIYQGHHHSLAPADINIVIDVIRAFTVAHYAFIGGAKEILL VRTADEAFALKDTYPDYVLTGEEKGVGISGFDLDNSPKRMAGQNMTDKSLIQKTTNGV TAALGALNAKHLFVTGFSNAKTTAQHVKKLVANDCVINIVASHPSGDDDMACAEYIKG IIEGTNVVTAAEAIERIKGSSVAEKFFDCRQPLFDSEDIVYCTKELTGDFVMKVKQDG EVPTIERVII*" /label="slpH CDS" gene 1061101..1061787 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /label="slpH gene" CDS 1061784..1062542 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /EC_number="4.4.1.19" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11830598, 15014443, 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho-3-sulfolactate synthase" /protein_id="NP_388976.1" /db_xref="EnsemblGenomes-Gn:BSU10950" /db_xref="EnsemblGenomes-Tr:CAB12935" /db_xref="GOA:O06739" /db_xref="InterPro:IPR003830" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036112" /db_xref="PDB:1U83" /db_xref="SubtiList:BG13109" /db_xref="UniProtKB/Swiss-Prot:O06739" /translation="MNDFSLELPVRTNKPRETGQSILIDNGYPLQFFKDAIAGASDYI DFVKFGWGTSLLTKDLEEKISTLKEHDITFFFGGTLFEKYVSQKKVNEFHRYCTYFGC EYIEISNGTLPMTNKEKAAYIADFSDEFLVLSEVGSKDAELASRQSSEEWLEYIVEDM EAGAEKVITEARESGTGGICSSSGDVRFQIVDDIISSDIDINRLIFEAPNKTLQQGFI QKIGPNVNLANIPFHDAIALETLRLGLRSDTFFL*" /label="slpS CDS" gene 1061784..1062542 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /label="slpS gene" downshifts 1062539 /Source="Nicolas_upshifts" /id="D594" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="2.37654" /MaxDrop="4.17689" /score="-1.32868938" /energy="-17.6" /TU="NA" /idTUdmin="U881" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1062587..1063216) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26335199; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388977.1" /db_xref="EnsemblGenomes-Gn:BSU10960" /db_xref="EnsemblGenomes-Tr:CAB12936" /db_xref="GOA:O06740" /db_xref="InterPro:IPR003740" /db_xref="SubtiList:BG13110" /db_xref="UniProtKB/Swiss-Prot:O06740" /translation="MAELLMKAKLTFMIVVGGVLQGLGMSLFLFPHDIPTGGAAGIAV LLHYLFQIPHGFSVWAVNVSMLFTALKWLEMRTFTGTLASITVTSVSVLIFDAVFPDI TSNLWLDLASGAVLLGLGIGLLYKYKISNGGFGALALMISIYRGGNPGTILLIMNCII FMVTASIIDWGIVIQALICQVISTRVIDFIYNIRLTSLPYLTPMYRHKK*" /label="yitE CDS" gene complement(1062587..1063216) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /label="yitE gene" promotor_-10 complement(1063250..1063268) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1063267) /Source="Nicolas_upshifts" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1063283..1063288) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1063312..1064427) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 11747447, 27994575; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enolase superfamily enzyme (isomerase /dehydratase)" /protein_id="NP_388978.1" /db_xref="EnsemblGenomes-Gn:BSU10970" /db_xref="EnsemblGenomes-Tr:CAB12937" /db_xref="GOA:O06741" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR036849" /db_xref="PDB:2GDQ" /db_xref="PDB:2GGE" /db_xref="SubtiList:BG13111" /db_xref="UniProtKB/Swiss-Prot:O06741" /translation="MKIVRIETFPLFHRLEKPYGDANGFKRYRTCYLIRIITESGIDG WGECVDWLPALHVGFTKRIIPFLLGKQAGSRLSLVRTIQKWHQRAASAVSMALTEIAA KAADCSVCELWGGRYREEIPVYASFQSYSDSPQWISRSVSNVEAQLKKGFEQIKVKIG GTSFKEDVRHINALQHTAGSSITMILDANQSYDAAAAFKWERYFSEWTNIGWLEEPLP FDQPQDYAMLRSRLSVPVAGGENMKGPAQYVPLLSQRCLDIIQPDVMHVNGIDEFRDC LQLARYFGVRASAHAYDGSLSRLYALFAQACLPPWSKMKNDHIEPIEWDVMENPFTDL VSLQPSKGMVHIPKGKGIGTEINMEIVNRYKWDGSAY*" /label="yitF CDS" gene complement(1063312..1064427) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /label="yitF gene" downshifts complement(1063341) /Source="Nicolas_upshifts" /id="D595" /incds=0 /nref=11 /ntot=42 /MaxReadThrough="1.81817" /MaxDrop="4.27426" /score="13.5713023" /energy="-14.5" /TU="NA" /idTUdmin="U883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1064436..1065704) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 14762009, 15109717, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388979.1" /db_xref="EnsemblGenomes-Gn:BSU10980" /db_xref="EnsemblGenomes-Tr:CAB12938" /db_xref="GOA:Q796Q1" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13112" /db_xref="UniProtKB/Swiss-Prot:Q796Q1" /translation="MESSKQNNGMTIVAIGSIPLILTLGNSMLIPILPKMKSELHLSQ FQVSLVITVFSLIAAFAIPIVGYLADRFSRKVIIIPCLILYGAGGLLAGFAAGFFDNA YPWVMAGRALQGIGAAGTGPIAMALTGDLFKGAQESKVLGLVEASNGMGKVLSPIIGS LIALLVWYGAFFAFPVFCIISIVLTWIFIKEKKKEKEPPPIGQYAKGLLSVFKHEGRW LFTAYLAGATCLFTLFGILFYLSDVLEKTYDTDGVKKGLILAIPLLVMCVTSYTTGSK IGQKQSLMKKLIVLGLAFMTVSYAALSFIENLVLFISVLVLSSIGSGLVLPCVNSFIT GAVGKERRGFVTSLYGSVRFLGVAIGPPIFGRLMQWSRPGMFLSIAGLTLVVGILVMM LIHVKQNNEETKEKEDPKMAGNRLQPAEER*" /label="yitG CDS" gene complement(1064436..1065704) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /label="yitG gene" promotor_-10 complement(1065730..1065741) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1065739) /Source="Nicolas_upshifts" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1065755..1065761) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1065816..1066664) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388980.1" /db_xref="EnsemblGenomes-Gn:BSU10990" /db_xref="EnsemblGenomes-Tr:CAB12939" /db_xref="GOA:O06743" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13113" /db_xref="UniProtKB/Swiss-Prot:O06743" /translation="MDVVDELIKLHEEHVSGLLRLCGQAGWPDYGEQELKLLVQQGRF FGYQNVSGDIISCIGLFLFGRLTSIGLVIVDKEYQRLGLGRRMVNACITQTDENTAIR LCATKEGLPLYEKAGFHTAGSVRKYSCHSFQPYTKKLDAELTSFREQDFHDLTAADLA AFGGDRSNLLQQLISASCECIIARNQDGQLIGYGLSVQTPANLKFGPIIAPSSDVAAQ IITRLAAGKQGPMRIDIPSEHTSLHDSLIEMGFHKDDEPPILFYQKKAPIQNGHLYAL ISQALG*" /label="yitH CDS" gene complement(1065816..1066664) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /label="yitH gene" downshifts complement(1065827) /Source="Nicolas_upshifts" /id="D596" /incds=0 /nref=34 /ntot=209 /MaxReadThrough="2.34135" /MaxDrop="3.51892" /score="14.8688564" /energy="-11.7" /TU="NA" /idTUdmin="U884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1066669..1067118) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388981.2" /db_xref="EnsemblGenomes-Gn:BSU11000" /db_xref="EnsemblGenomes-Tr:CAB12940" /db_xref="GOA:O06744" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13114" /db_xref="UniProtKB/Swiss-Prot:O06744" /translation="MLEVKTISVEDTYEIRHRILRPHQSIEQCKYKEDHAEGSFHLGV FYDGTLISIASFSPQSQPLLTEASAYRLRGMATLEGYRDQKAGSTLIKHAEHKLAESG VQAVWCNARHHVKGYYAKLGWKELGEPFDIPGIGNHIVMYKTLRTSR*" /label="yitI CDS" gene complement(1066669..1067118) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /label="yitI gene" promotor_-10 complement(1067139..1067158) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1067153) /Source="Nicolas_upshifts" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1067174..1067175) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1067208..1069046) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /EC_number="1.5.1.20" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 17264075, 20421295, 20951706, 26233166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional homocysteine S-methyltransferase using (R,S)AdoMet and methylenetetrahydrofolate reductase [NAD(P)H]" /protein_id="NP_388982.1" /db_xref="EnsemblGenomes-Gn:BSU11010" /db_xref="EnsemblGenomes-Tr:CAB12941" /db_xref="GOA:O06745" /db_xref="InterPro:IPR003171" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR029041" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG13115" /db_xref="UniProtKB/Swiss-Prot:O06745" /translation="MGLLEDLQRQVLIGDGAMGTLLYSYGIDRCFEELNISKPEEIQR IHKAYVEAGANIIQTNTYGANYIKLSRHGLEDDIKKMNQEAVKIARASAGDAYVLGTM GGIRTFNKNAYSLDEIKRSFREQLYLLLHEEPDGLLLETYYDLEEAREVLKIARKETD LPIMLNVSMHEQGVLQDGTPLSDALRSIADLGADIVGINCRLGPYHMIEALSEVPIFD DVFLSVYPNSSLPSLEEGRLVYETDDTYFQNSASEFRKQGARIIGGCCGTTPNHIRAM AEAVGGLAPITEKEVKTRAKEFISVHHERTEPGLDEIAAKKRSIIVELDPPKKLSFDK FLSAAAELKEAGIDALTLADNSLATPRISNVACGALVKQQLDMRSLVHITCRDRNIIG LQSHLMGLDTLGLNDVLAITGDPSKIGDFPGATSVYDLTSFDLIRLIKQFNEGLSLSG KPLGKKTNFSVAAAFNPNVRHLDKAVKRLEKKIDCGADYFVSQPVYSEQQLVDIHNET KHLKTPIYIGIMPLTSSRNAEFIHNEIPGIKLSDTIREKMAHAGEDKEKQKAEGLAIA RSLLDTACELFNGIYLITPFLRSDLTAELTSYIQQKDEQRQNIFLH*" /label="samT CDS" gene complement(1067208..1069046) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /label="samT gene" downshifts complement(1067235) /Source="Nicolas_upshifts" /id="D597" /incds=0 /nref=14 /ntot=91 /MaxReadThrough="3.04289" /MaxDrop="4.13744" /score="12.9586126" /energy="-16.2" /TU="U885" /idTUdmin="U885" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts complement(1069128) /Source="Nicolas_upshifts" /id="D598" /incds=0 /nref=47 /ntot=128 /MaxReadThrough="8.00128" /MaxDrop="5.61487" /score="22.3754155" /energy="-7.3" /TU="U885,U887" /idTUdmin="U887" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1069136..1069253) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswK RNA" gene complement(1069136..1069253) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /label="mswK gene" promotor_-10 complement(1069305..1069324) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" upshifts complement(1069319) /Source="Nicolas_upshifts" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1069339..1069346) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS complement(1069360..1069851) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12943362, 25329577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA or cyclic d-GMP binding protein" /protein_id="NP_388983.1" /db_xref="EnsemblGenomes-Gn:BSU11020" /db_xref="EnsemblGenomes-Tr:CAB12942" /db_xref="InterPro:IPR007551" /db_xref="InterPro:IPR035570" /db_xref="InterPro:IPR035571" /db_xref="InterPro:IPR036183" /db_xref="SubtiList:BG13116" /db_xref="UniProtKB/Swiss-Prot:O06746" /translation="MAKESSFDIVSKVELPEVQNAIQIALKEISTRYDFKGSKSDISL DKEELVLVSDDEFKLSQLKDVLVSKLIKRNVPTKNIDYGKVENASGGTVRQRAKLVQG IDKDNAKKINTIIKNSGLKVKSQVQDDQVRVTGKNKDDLQQIISAVRGADLPIDVQFI NFR*" /label="yitK CDS" gene complement(1069360..1069851) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /label="yitK gene" promotor_-35 1069869..1069872 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1069875..1069894) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" promotor_-10 1069887..1069906 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1069888 /Source="Nicolas_upshifts" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1069893) /Source="Nicolas_upshifts" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1069909..1069916) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS 1069950..1070846 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20399190; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA-binding protein" /protein_id="NP_388984.1" /db_xref="EnsemblGenomes-Gn:BSU11030" /db_xref="EnsemblGenomes-Tr:CAB12943" /db_xref="GOA:O06747" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014464" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13117" /db_xref="UniProtKB/Swiss-Prot:O06747" /translation="MLTKSAENKRNRKDDSMRPGQQLTLSIDHQTDFGYFLTDGEDTI LLHNSEMTEDIEDRDEVEVFIYVDQQERLAATMKIPIISADEYGWVEVVDKVEDMGVF VDVGLSKDALVATEHLPPYEDVWPQKGDKLYCMLKVTNRGRMFAKPAPEDIISELFTD ASEDLMNKELTGTVYRLIASGSFVITDDGIRCFIHPSERKEEPRLGSRVTGRVIQVKE DGSVNLSLLPRKQDAMSVDAECILTYMRMRNGAMPYSDKSQPDDIRERFNMSKAAFKR ALGHLMKNGKVYQENGWTYEKK*" /label="yitL CDS" gene 1069950..1070846 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /label="yitL gene" downshifts 1070833 /Source="Nicolas_upshifts" /id="D599" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="1.78082" /MaxDrop="6.73614" /score="40.361011" /energy="-21.5" /TU="NA" /idTUdmin="U886" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1070899..1071483) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388985.1" /db_xref="EnsemblGenomes-Gn:BSU11040" /db_xref="EnsemblGenomes-Tr:CAB12944" /db_xref="GOA:O06748" /db_xref="InterPro:IPR023888" /db_xref="SubtiList:BG13118" /db_xref="UniProtKB/Swiss-Prot:O06748" /translation="MKKAFLVFLSVVLVTTVFLVKQQESVAQAKQLEYSGEEIFKGFV FAQGEVGKQLPEVFNKAMTDKLNTKQAKAFANQVVADIKKEDADFFDNLKKAVYSKDA LKVDELLKKAGQIVEEKVEAAKEIAASKDDTSRVQAELVNTVDTANYFYYVSYVAAAG ALILIILAIDITPIAISDNVDREMAIRTLVDELN*" /label="yitM CDS" gene complement(1070899..1071483) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /label="yitM gene" downshifts complement(1070909) /Source="Nicolas_upshifts" /id="D600" /incds=0 /nref=68 /ntot=158 /MaxReadThrough="1.3386" /MaxDrop="7.40935" /score="10.143892" /energy="-21.5" /TU="NA" /idTUdmin="U888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1071480..1072409) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11557812, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with HTTM domain" /protein_id="NP_388987.2" /db_xref="EnsemblGenomes-Gn:BSU11055" /db_xref="EnsemblGenomes-Tr:CAB12946" /db_xref="GOA:O06750" /db_xref="InterPro:IPR011020" /db_xref="InterPro:IPR023894" /db_xref="SubtiList:BG13120" /db_xref="UniProtKB/Swiss-Prot:O06750" /translation="MLENIKQTITRWDERNPWTNVYGLARSIIALSSLLTLLINHPSL IMKPASGISSYPACKMNLSLFCLGENNYMMLNLFRWVCIAILVLVVIGWRPRITGVLH WYVSYSLQSSLIVIDGGEQAAAVMTFLLLPITLTDPRKWHWSTRPIEGKRTLGKITAF ISYFVIRIQVAVLYFHSTVAKLSQQEWVDGTAVYYFAQEKTIGFNGFFQALTKPIVTS PFVVIPTWGTLLVQIVIFAALFAPKKHWRLILIIAVFMHEIFAVMLGLISFSIIMAGI LILYLTPIDSTIQFTYIRRLLWNKKHKKGEVSV*" /label="yitO CDS" gene complement(1071480..1072409) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /label="yitO gene" upshifts complement(1071567) /Source="Nicolas_upshifts" /id="U888" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.232767232767233" /psig="0.63936063936064" /xcortree=2974 /SigmaFactorBS="agtcatgctgggcctcatcagtttttcgattatcatggccgg cattttgatattgtatctcaCtcctatcgattccacgattcaatttacatatattcgc a" /listShort="yitM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1072394..1072930) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 6289325, 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388988.1" /db_xref="EnsemblGenomes-Gn:BSU11070" /db_xref="EnsemblGenomes-Tr:CAB12947" /db_xref="GOA:O06751" /db_xref="InterPro:IPR023902" /db_xref="SubtiList:BG13121" /db_xref="UniProtKB/Swiss-Prot:O06751" /translation="MQKSISFFVIFSILWGSLFLFSIIGSLGTTPIPLTKDSKFLMSS ILPQGWGFFSKNPRDTAIGLYEAENASAKVRWPNMRADNLFGLYRYGRSQGVEMGVIY SQVGKEQWTACKEKDLGACKSKAKTVQLKTPAPRPLLCGSYYLTKEDIVPWSYSKYTP SSYQVKSIVKVVISCSKT*" /label="yitP CDS" gene complement(1072394..1072930) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /label="yitP gene" promotor_-10 complement(1072966..1072985) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1072980) /Source="Nicolas_upshifts" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1073000..1073003) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1073071..1073078 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1073093..1073112 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1073096 /Source="Nicolas_upshifts" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="upshifts" CDS 1073108..1073455 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097701.1" /db_xref="EnsemblGenomes-Gn:BSU11079" /db_xref="EnsemblGenomes-Tr:CAX52589" /db_xref="GOA:C0H3Y4" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Y4" /translation="MKTNQVNDRWIVQFRKGIFELAILSLLRSKPMYGYELTSSLKTT SALAISEGAIYPILKRMTEKGWIEFFWEDSLDGPKRKYYKMTQKGEEMLKERLEKYLE THQALLSLSGDLL*" /label="yizB CDS" gene 1073108..1073455 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /label="yizB gene" CDS 1073452..1074039 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23504016" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388989.2" /db_xref="EnsemblGenomes-Gn:BSU11080" /db_xref="EnsemblGenomes-Tr:CAB12948" /db_xref="GOA:O06752" /db_xref="SubtiList:BG13122" /db_xref="UniProtKB/Swiss-Prot:O06752" /translation="MNGQLIIDRYMEELNAELANMPDVERENAIDELKGHITAFVQDR IKAGLSEEELQEAVESEFSHPKELAELMMGDGGETKRRRSLLGKSWISVLLIVTIIAL PLLPSDFRHLPLAVYLMVLAGYVWKRKKLVMFAGVRKNKMRSQKEIVKISRVGAVYLL FLAVVLLLSPFLNALVVLLLIAVSCAAFFLFLNIK*" /label="yitQ CDS" gene 1073452..1074039 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /label="yitQ gene" CDS 1074059..1074352 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388990.1" /db_xref="EnsemblGenomes-Gn:BSU11090" /db_xref="EnsemblGenomes-Tr:CAB12949" /db_xref="GOA:O06753" /db_xref="InterPro:IPR017259" /db_xref="SubtiList:BG13123" /db_xref="UniProtKB/Swiss-Prot:O06753" /translation="MEISINYLLIVIALLFFVVAYFVGIKKQTWMLAGFNEARIRDKD RLARIAGYFFLNSGLFILLNSFISFQGQEQLIPPLILAYGAGVIIYVNKKLVE*" /label="yitR CDS" gene 1074059..1074352 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /label="yitR gene" downshifts 1074332 /Source="Nicolas_upshifts" /id="D601" /incds=0 /nref=119 /ntot=240 /MaxReadThrough="1.96008" /MaxDrop="5.72545" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1074376 /Source="Nicolas_upshifts" /id="D602" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="0.34732" /MaxDrop="3.0285" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS 1074488..1076104 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1917867, 16672610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1917867, 16672610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral protease B" /protein_id="NP_388991.1" /db_xref="EnsemblGenomes-Gn:BSU11100" /db_xref="EnsemblGenomes-Tr:CAB12950" /db_xref="GOA:P39899" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10691" /db_xref="UniProtKB/Swiss-Prot:P39899" /translation="MRNLTKTSLLLAGLCTAAQMVFVTHASAEESIEYDHTYQTPSYI IEKSPQKPVQNTTQKESLFSYLDKHQTQFKLKGNANSHFRVSKTIKDPKTKQTFFKLT EVYKGIPIYGFEQAVAMKENKQVKSFFGKVHPQIKDVSVTPSISEKKAIHTARRELEA SIGKIEYLDGEPKGELYIYPHDGEYDLAYLVRLSTSEPEPGYWHYFIDAKNGKVIESF NAIHEAAGTGIGVSGDEKSFDVTEQNGRFYLADETRGKGINTFDAKNLNETLFTLLSQ LIGYTGKEIVSGTSVFNEPAAVDAHANAQAVYDYYSKTFGRDSFDQNGARITSTVHVG KQWNNAAWNGVQMVYGDGDGSKFKPLSGSLDIVAHEITHAVTQYSAGLLYQGEPGALN ESISDIMGAMADRDDWEIGEDVYTPGIAGDSLRSLEDPSKQGNPDHYSNRYTGTEDYG GVHINSSIHNKAAYLLAEGGVHHGVQVEGIGREASEQIYYRALTYYVTASTDFSMMKQ AAIEAANDLYGEGSKQSASVEKAYEAVGIL*" /label="nprB CDS" gene 1074488..1076104 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /label="nprB gene" downshifts 1076092 /Source="Nicolas_upshifts" /id="D603" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="0.278770000000001" /MaxDrop="3.08544" /score="2.81939887" /energy="-8.6" /TU="NA" /idTUdmin="U890" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" CDS complement(1076151..1077002) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit B" /protein_id="NP_388992.1" /db_xref="EnsemblGenomes-Gn:BSU11110" /db_xref="EnsemblGenomes-Tr:CAB12951" /db_xref="GOA:P70945" /db_xref="InterPro:IPR003797" /db_xref="SubtiList:BG12244" /db_xref="UniProtKB/Swiss-Prot:P70945" /translation="MTVHLIADSATDLPRSYFEEKGIGFIPLRVSLGDKEFEDAVTIH ADQIFEAMQNGETPKTSQASPQTIKNVFLQYAETGDPALYIAFSSGLSGTYQTAVMIA NEVKEEFPDFDLRVIDSKCASLGYGLAVRHAADLCINGNTIQEIETSVKNFCSQLEHI FTVDDLTYLARGGRISKTSAFVGGLLNIKPLLQMEDGKLVPLEKIRGQKKLFKRIIEL MKERGDDWSNQTVGISYAANKEKATDMKHLIEEAFKPKEIIMHPISSAIGSHAGPGTL AIFFLRK*" /label="fakBB CDS" gene complement(1076151..1077002) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /label="fakBB gene" downshifts complement(1076168) /Source="Nicolas_upshifts" /id="D604" /incds=0 /nref=209 /ntot=263 /MaxReadThrough="0.727580000000001" /MaxDrop="6.86927" /score="-1.24586831" /energy="-7.7" /TU="NA" /idTUdmin="U892" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1076549..1076556 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1076571..1076590 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1076576..1077101 /Source="Nicolas_S_feature" /locus_tag="new_1188125_1188650" /HighExp="G180, Paraq, G135, G150, Oxctl, C30, H2O2, LBGstat, LBGexp, Lbexp" /AntisenseName="yitS" /AntisenseCor="-0.45830528686941202" /AntisenseRegPval="-14.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S395" upshifts 1076578 /Source="Nicolas_upshifts" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1077043..1077062) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1077066) /Source="Nicolas_upshifts" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1077080..1077085 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1077100..1077118 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1077103 /Source="Nicolas_upshifts" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" CDS 1077140..1077982 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23419162, 23824080; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388993.1" /db_xref="EnsemblGenomes-Gn:BSU11120" /db_xref="EnsemblGenomes-Tr:CAB12952" /db_xref="GOA:P39803" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG10850" /db_xref="UniProtKB/Swiss-Prot:P39803" /translation="MVLDQTKKLLIVIIGALLNAAGLNLFLIPADVYASGFTGVAQLL SSVVDQYAPFYISTGTLLFLLNIPVGILGWLKVGKSFTVYSILSVALTTLFMGILPET SLSHDILLNAVFGGVISAVGIGLTLKYGASTGGLDIVAMVLAKWKDKPVGTYFFILNG IIILTAGLLQGWEKALYTLVTLYVTTRVIDAIHTRHMKLTAMIVTKKADEIKEAIYGK MVRGITTVPAKGAFTNEQKEMMIIVITRYELYDLEKIVKEVDPKAFTNIVQTTGIFGF FRKD*" /label="yitT CDS" gene 1077140..1077982 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /label="yitT gene" promotor_-35 1077635..1077643 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1077654..1077672 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1077654 /Source="Nicolas_upshifts" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="upshifts" S_feature 1077983..1078096 /Source="Nicolas_S_feature" /locus_tag="new_1189532_1189645" /HighExp="Etha, S8, Sw, M9-stat, S7, BC, Gly, S6, Salt, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigB, SigA" /TUshortPSig="0.968, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S396" CDS 1078097..1078456 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8226659, 24555072" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226659, 24555072; Product type f: factor" /codon_start=1 /transl_table=11 /product="intracellular proteinase inhibitor BsuPI" /protein_id="NP_388994.1" /db_xref="EnsemblGenomes-Gn:BSU11130" /db_xref="EnsemblGenomes-Tr:CAB12953" /db_xref="GOA:P39804" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR020481" /db_xref="PDB:3ISY" /db_xref="SubtiList:BG10852" /db_xref="UniProtKB/Swiss-Prot:P39804" /translation="MENQEVVLSIDAIQEPEQIKFNMSLKNQSERAIEFQFSTGQKFE LVVYDSEHKERYRYSKEKMFTQAFQNLTLESGETYDFSDVWKEVPEPGTYEVKVTFKG RAENLKQVQAVQQFEVK*" /label="ipi CDS" gene 1078097..1078456 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /label="ipi gene" downshifts 1078445 /Source="Nicolas_upshifts" /id="D605" /incds=0 /nref=34 /ntot=224 /MaxReadThrough="1.36729" /MaxDrop="5.6855" /score="43.7575824" /energy="-15.6" /TU="NA" /idTUdmin="U893" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1078487..1078684) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; genus orphan" /protein_id="YP_003097702.1" /db_xref="EnsemblGenomes-Gn:BSU11139" /db_xref="EnsemblGenomes-Tr:CAX52590" /db_xref="InterPro:IPR024217" /db_xref="UniProtKB/Swiss-Prot:C0H3Y5" /translation="MRNELFQQAKSFVQQAVMVTNGFEEGDQEQAILRAKNAVSSAYA NSTDAERQQLHQFQNQLDKLQ*" /label="yizC CDS" gene complement(1078487..1078684) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /label="yizC gene" downshifts complement(1078500) /Source="Nicolas_upshifts" /id="D606" /incds=0 /nref=150 /ntot=257 /MaxReadThrough="1.42333" /MaxDrop="8.284" /score="2.35557074" /energy="-17.3" /TU="NA" /idTUdmin="U895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1078685..1078881) /Source="Nicolas_S_feature" /locus_tag="new_1190234_1190430_c" /HighExp="S8, S6, S5, S7, nit, ferm, BT, G/S, Pyr, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99834599999999996" /TUshortSig="SigGF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S397" upshifts complement(1078881) /Source="Nicolas_upshifts" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1078883..1078894) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1078909..1078915) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1078941..1079753) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25012491, 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous)" /protein_id="NP_388995.1" /db_xref="EnsemblGenomes-Gn:BSU11140" /db_xref="EnsemblGenomes-Tr:CAB12954" /db_xref="GOA:P70947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12245" /db_xref="UniProtKB/Swiss-Prot:P70947" /translation="METKPYLIALDLDGTLLKDDKTISENTLHTIQRLKDDGHYVCIS TGRPYRSSSMYYQQMELTTPIVNFNGAFVHHPQDDSWGRYHTSLPLDVVKQLVDISES YNVHNVLAEVIDDVYFHYHDEHLIDAFNMNTTNVTVGDLRENLGEDVTSVLIHAKEED VPAIRSYLSDVHAEVIDHRRWAAPWHVIEIIKSGMNKAVGLQKISDYYGVPRERIIAF GDEDNDLEMLEFAGCGVAMGNGIDAVKQIANRTTATNEEDGVARFLKEYFSL*" /label="ribZC CDS" gene complement(1078941..1079753) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /label="ribZC gene" promotor_-10 complement(1079791..1079810) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1079811..1079818 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1079811) /Source="Nicolas_upshifts" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1079824..1079831) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1079830..1079849 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1079832 /Source="Nicolas_upshifts" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1079874..1080641 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28293230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxylesterase" /protein_id="NP_388996.1" /db_xref="EnsemblGenomes-Gn:BSU11150" /db_xref="EnsemblGenomes-Tr:CAB12955" /db_xref="GOA:P70948" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12246" /db_xref="UniProtKB/Swiss-Prot:P70948" /translation="MIQIENQTVSGIPFLHIVKEENRHRAVPLVIFIHGFTSAKEHNL HIAYLLAEKGFRAVLPEALHHGERGEEMAVEELAGHFWDIVLNEIEEIGVLKNHFEKE GLIDGGRIGLAGTSMGGITTLGALTAYDWIKAGVSLMGSPNYVELFQQQIDHIQSQGI EIDVPEEKVQQLMKRLELRDLSLQPEKLQQRPLLFWHGAKDKVVPYAPTRKFYDTIKS HYSEQPERLQFIGDENADHKVPRAAVLKTIEWFETYL*" /label="yitV CDS" gene 1079874..1080641 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /label="yitV gene" promotor_-35 1080650..1080656 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1080670 /Source="Nicolas_upshifts" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1080671..1080690 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1080705..1081013 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9209063; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein involved in Fe-S cluster assembly, PaaD-like" /protein_id="NP_388997.1" /db_xref="EnsemblGenomes-Gn:BSU11160" /db_xref="EnsemblGenomes-Tr:CAB12956" /db_xref="InterPro:IPR002744" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG12247" /db_xref="UniProtKB/Swiss-Prot:P70949" /translation="MEEALKENIMGALEQVVDPELGVDIVNLGLVYDVDMDEDGLTHI TMTLTSMGCPLAPIIVDEVKKALADLPEVKDTEVHIVWNPPWTRDKMSRYAKIALGIQ *" /label="yitW CDS" gene 1080705..1081013 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /label="yitW gene" downshifts 1080998 /Source="Nicolas_upshifts" /id="D607" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="5.65659" /MaxDrop="4.5598" /score="14.9971829" /energy="-14.7" /TU="U897,U898" /idTUdmin="U897" /TUdmin="-2244" /isTUend="FALSE" /label="downshifts" S_feature 1081043..1081308 /Source="Nicolas_S_feature" /locus_tag="new_1192592_1192857" /HighExp="Etha, dia15, dia5, H2O2, LoTm, Salt, S6, Diami, S8, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S398" CDS 1081309..1082739 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16956367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN/FAD-binding oxidoreductase" /protein_id="NP_388999.3" /db_xref="EnsemblGenomes-Gn:BSU11170" /db_xref="EnsemblGenomes-Tr:CAB12958" /db_xref="GOA:Q796P5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12249" /db_xref="UniProtKB/Swiss-Prot:Q796P5" /translation="MKKKLLAFALCTGAYAALFAYSVNSEQKTATSEMTDVSRLMPVK IKQTVKGQEEEMLIDTVKEANRKNIKISIAGAQHSMGGHTYYEDGIVLDMTGYNKILS LDQEKKTIRVQSGATWNDIQKYVNPYGLAVKVMQSQNIFTIGGSLSANAHGRDIRYGS LIDTVKSFRLLKADGMIITVTPKDDLFTAVIGGYGLFGVILDVTLELTDDELYVMKTE KMNYSTYSDYFSKHVKGNPDVRMHLARISTAKKGFLKDMYVTNYVLANHQDQLSSYSE LKEDEYTGATKFALGLSRRYEWGRNWLWDTQQSYFLSQNGTEISRNNVMRSESKFLEY ENNDNTDVLQEYFVPVKEYGSYIDDLRQTLSDEDLNLLNITIRYVQKNEKADLSYAKD DMFSLVLLINEGFSKEDQADTARIIRRMTDVAIKHGGSYYLPYMTYQTKAQMRQAYPK SEAFFQKKRTYDPDERFMNYFYQRYK*" /label="yitY CDS" gene 1081309..1082739 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /label="yitY gene" CDS 1082784..1083278 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transport protein" /protein_id="NP_389000.1" /db_xref="EnsemblGenomes-Gn:BSU11180" /db_xref="EnsemblGenomes-Tr:CAB12959" /db_xref="GOA:P70952" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12250" /db_xref="UniProtKB/Swiss-Prot:P70952" /translation="MFFASSLIFPFYILFVKNIGSSYTQFGFSYGLFGLSGALIYPLL GRLSERFDSRYFLLLNSWGMAVLLLYVPHIGSVVQVYIVQVLLGLFGAMQKHGEKVLI ANFTDSGERGKKIGNYHFWTAVFSAAAIMLGGFLADFFTVQMIFYASSILYFLSGLMM MKTG*" /label="yitZ CDS" gene 1082784..1083278 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /label="yitZ gene" downshifts 1083242 /Source="Nicolas_upshifts" /id="D608" /incds=0 /nref=49 /ntot=208 /MaxReadThrough="1.74762" /MaxDrop="4.22077" /score="34.1294744" /energy="-13.2" /TU="NA" /idTUdmin="U897" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1083416..1083423 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1083422 /Source="Nicolas_upshifts" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1083437..1083456 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1083485..1084522 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /EC_number="1.2.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate gamma-semialdehyde dehydrogenase" /protein_id="NP_389001.2" /db_xref="EnsemblGenomes-Gn:BSU11190" /db_xref="EnsemblGenomes-Tr:CAB12960" /db_xref="GOA:P23715" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR000706" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR023013" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10191" /db_xref="UniProtKB/Swiss-Prot:P23715" /translation="MKIGIVGATGYGGTELVRILSHHPHAEECILYSSSGEGNVYSEG YPHLTGLADQQLKPIDMNTIKHEIDIMFLAAPPGVSSELTPKLADAGITVIDLSGDLR IKEPAEYEKWYKRTAAPKAVIQEAVYGLAELNQLQIQQAKLIANPGCFPTAVLLGLAP LAQKKLLDESFVIVDAKTGVSGAGRKASMGTHFSELNDNFKIYKVNEHQHTPEIEQAL NEWQPGLGPITFSAHLVPMTRGIMATMYTRLTCDLTADDLHDLYSEFYQDSYFVRVRP KGQYPQTKEVYGSNFCDIAVTLDERTNRVTIVSVIDNLMKGAAGQAVQNFNLMNGWNE ETGLTITPIYP*" /label="argC CDS" gene 1083485..1084522 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /label="argC gene" CDS 1084542..1085762 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /EC_number="2.3.1.1" /EC_number="2.3.1.35" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8025667, 10931207, 16409639, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8025667, 10931207, 16409639, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine acetyltransferase; amino-acid acetyltransferase" /protein_id="NP_389002.2" /db_xref="EnsemblGenomes-Gn:BSU11200" /db_xref="EnsemblGenomes-Tr:CAB12961" /db_xref="GOA:P36843" /db_xref="InterPro:IPR002813" /db_xref="InterPro:IPR016117" /db_xref="SubtiList:BG10192" /db_xref="UniProtKB/Swiss-Prot:P36843" /translation="MIQLSEDQIVKVTGDVSSPKGFQAKGVHCGLRYSKKDLGVIISE TPAVSAAVYTQSHFQAAPIKVTQDSLKHGPTLKAVIVNSAIANACTGEQGLKDAYTMR ESFASQLGIEPELVAVSSTGVIGEHLDMEKIHAGIELLKETPAGSGDFEEAILTTDTV IKQTCYELAIGGKTVTIGGAAKGSGMIHPNMATMLGFVTTDAAIEEKALQKALREITD VSFNQITVDGETSTNDMVLVMANGCAENECLTEDHPDWPVFKKALLLTCEDLAKEIAR DGEGATKLIEAQVQGAKNNLDANVIAKKIVGSNLVKTAVYGTDANWGRIIGAIGHSAA QVTAEEVEVYLGGQCLFKNNEPQPFSESIAKEYLEGDEITIVIKMAEGDGNGRAWGCD LTYDYIKINASYRT*" /label="argJ CDS" gene 1084542..1085762 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /label="argJ gene" CDS 1085777..1086553 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /EC_number="2.7.2.8" /experiment="publication(s) with functional evidences, PMID:3005232, 8473852" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3005232, 8473852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate 5-phosphotransferase (acetylglutamate kinase)" /protein_id="NP_389003.1" /db_xref="EnsemblGenomes-Gn:BSU11210" /db_xref="EnsemblGenomes-Tr:CAB12962" /db_xref="GOA:P68729" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR004662" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10193" /db_xref="UniProtKB/Swiss-Prot:P68729" /translation="MKKTIVFKCGGSVIRELSEEFYQNLKELRASGWKLAIVHGGGPE ITNMLKRLNIKTEFSGGQRKTTKPVLEVAEMVLSGSVNKFFVAELAKHGLRAAGISGK DGGLLEADYLDPETYGEVGEIKKVDASMVNALMENGIIPVIAPLSMTSDCKTLNVNAD LAASAVAGALEADKLMFVTDVDGIMKEKQRLDVLTPKEIQMLIKQEVITGGMIPKVNS ALSALSDQVSEVMIVNGKGSFFAEQTFQGTKIVKAKEAVS*" /label="argB CDS" gene 1085777..1086553 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /label="argB gene" CDS 1086550..1087707 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /EC_number="2.6.1.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17012789; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylornithine aminotransferase" /protein_id="NP_389004.2" /db_xref="EnsemblGenomes-Gn:BSU11220" /db_xref="EnsemblGenomes-Tr:CAB12963" /db_xref="GOA:P36839" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10194" /db_xref="UniProtKB/Swiss-Prot:P36839" /translation="MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLG HCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKLAAHSAGDLVFFCNSGAEANEGA IKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAF KALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTG KGFAYEHFGLSPDIITVAKGLGNGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAA VNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKGLMLGIECDGPVADI IAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ*" /label="argD CDS" gene 1086550..1087707 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /label="argD gene" CDS 1087778..1088833 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 230177, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 230177, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(small subunit)" /protein_id="NP_389005.2" /db_xref="EnsemblGenomes-Gn:BSU11230" /db_xref="EnsemblGenomes-Tr:CAB12964" /db_xref="GOA:P36838" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10195" /db_xref="UniProtKB/Swiss-Prot:P36838" /modified_by="User" /translation="MEGYLVLEDGTSFSGELDGHENCTGEAVFFTGMTGYQEVLTDPS YKGQIIVFTYPLIGNYGINEKDFESKKPQVKAAVVYEACDHFSHYEAVYSLKEYLQKW NIPLLTHVDTRAVVKKIRANGTMGATVTASKEGAEIALQPENVAEQASAQEISTFGDG NKHIALIDFGYKKSIASSLVKRGCKVTVVPYQQMEAVYNIKPDGLSNGPGDPKAIQPY LGKIKSIISRFPTLGICLGHQLIALAFGGNTFKLPFGHRGANHPVIDRKTKRVFMTSQ NHSYVVDEQSINEEELTIRFHHVNDTSVEGLAHKKLPVMSVQFHPEAHPGPAESEWIF DDYLKNVIPARREIAHA*" /label="Delta6_BSU_11230_SNPvariant" gene 1087778..1088833 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /modified_by="User" /label="Delta6_BSU_11230_SNPvariant" Polymorphism join(1088388,1088389) /Source="geneious" /ID="SNP_BsDelta6_1199938_1199943" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=6 /Amino_Acid_Change="GIV -> G" /CDS_Position=612 /Change="-AATTGT" /Codon_Change="GGA,ATT,GTG -> GGG" /Coverage="183 -> 185" /locus_tag="BSU_11230" /Protein_Effect="Deletion" /Reference_Frequency /Reference_Nucleotides="AATTGT" /Variant_Nucleotides /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="Delta6_BSU_11230_SNPvariant" / /modified_by="User" /label="Polymorphism_Delta6" misc_feature complement(1088667..1088686) /Source="Nicolas_upshift_promotors" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1088677) /Source="Nicolas_upshifts" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1088826..1091918 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(large subunit)" /protein_id="NP_389006.3" /db_xref="EnsemblGenomes-Gn:BSU11240" /db_xref="EnsemblGenomes-Tr:CAB12965" /db_xref="GOA:P18185" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR036897" /db_xref="SubtiList:BG10196" /db_xref="UniProtKB/Swiss-Prot:P18185" /translation="MPKDTSISSILVIGSGPIIIGQAAEFDYSGTQGCIALKEEGYRV ILVNSNPATIMTDEAFADEIYFEPLTAESLTAIIKKERPDGLLANLGGQTALNLAVEL EETGVLKEHGVKLLGTSVETIQKGEDREKFRSLMNELKQPVPESEIVDNEADALHFAE SIGFPVIIRPAYTLGGKGGGIAPDKEAFTAMIKQALLASPINQCLVEKSIAGFKEIEY EVMRDSNNTCITVCNMENIDPVGVHTGDSIVVAPSQTLTDEDYQMLRTASLTIISALD VVGGCNIQFALDPFSKQYYVIEVNPRVSRSSALASKATGYPIAKMAAKLAVGYTLDEL KNPLTGSTYASFEPALDYVIVKFPRWPFDKFKNADRKLGTKMKATGEVMAIERNLEAA IQKAAASLELKNIGTHLPELSGLSIDTLWDLAITPDDRRFFVVMELLSRSVSIDDIHE KTKIDPFFLHTFDNIIKLENRLMEAGSDLSFELLKKAKEKGFSDATIASLISKTEEEV RALRKEMGITPSFKIVDTCAAEFDAKTNYFYSTYFGETDGDISRKEKKRALIIGSGPI RIGQGVEFDYSAVHGVLTLQELGFETIMINNNPETVSTDYEIADRLYFEPMTTEHIVN VAEQENIDFAIVQFGGQTAINAAEALEKAGITLLGTSFQTLDVLEDRDQFYQLLDELG LKHAKGEIAYTKEEAASKASEIGYPVLIRPSYVIGGMGMIIVDSQAQLSQLLNDEDSM PYPILIDQYVSGKEVEIDLISDGEEVFIPTYTEHIERAGVHSGDSFAILPGPSITSGL QQGMKDAAQKIARKLSFKGIMNIQFVIDNGNILVLEVNPRASRTVPVVSKVMGVPMIP LATRLLAGASLKDLNPAVQNHHGVAVKFPVFSSHAIQDVDVKLGPEMKSTGEGMCVAY DSNSALKKIYTRVWSQKGSIYLQNVPEDVKELAENAGFTIHEGTFASWMEQEGNSLHI NLSGSEEARKERLEAMTHGIPVFTEEETVRAFLQSGSGHPQPVSLKDLYKKEVASCTQ *" /label="carB CDS" gene 1088826..1091918 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /label="carB gene" CDS 1091906..1092865 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /EC_number="2.1.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3099126, 6409881, 8025667, 9346304, 16585758, 26443366" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3099126, 6409881, 8025667, 9346304, 16585758, 26443366; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ornithine carbamoyltransferase" /protein_id="NP_389007.1" /db_xref="EnsemblGenomes-Gn:BSU11250" /db_xref="EnsemblGenomes-Tr:CAB12966" /db_xref="GOA:P18186" /db_xref="InterPro:IPR002292" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR024904" /db_xref="InterPro:IPR036901" /db_xref="SubtiList:BG10197" /db_xref="UniProtKB/Swiss-Prot:P18186" /translation="MHTVTQTSLYGKDLLTLKDLSEEDINALLAEAGELKQNKIQPIF HGKTLAMIFEKSSTRTRVSFEAGMAQLGGSALFLSQKDLQLGRGETVADTAKVLSGYV DAIMIRTFEHEKVEELAKEADIPVINGLTDKYHPCQALADLLTIKEIKGKLKGVKVAY IGDGNNVAHSLMIGCAKMGCDISIASPKGYEVLDEAAEAAKTYALQSGSSVTLTDDPI EAVKDADVIYSDVFTSMGQEAEEQERLAVFAPYQVNAALVSHAKPDYTFLHCLPAHRE EEVTAEIIDGPNSAVFQQAENRLHVQKALLKAILYKGESSKNC*" /label="argF CDS" gene 1091906..1092865 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /label="argF gene" downshifts 1092828 /Source="Nicolas_upshifts" /id="D609" /incds=0 /nref=141 /ntot=268 /MaxReadThrough="4.29547" /MaxDrop="7.69347" /score="22.2660758" /energy="-11.1" /TU="U899" /idTUdmin="U899" /TUdmin="-305" /isTUend="FALSE" /label="downshifts" S_feature complement(1092868..1093142) /Source="Nicolas_S_feature" /locus_tag="new_1204423_1204697_c" /HighExp="G135, G180, Cold, LBGexp, G150, B60, LoTm, Paraq, Oxctl, H2O2" /AntisenseName="yjzC" /AntisenseCor="-0.37122740772860502" /AntisenseRegPval="-9.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S399" promotor_-35 1092893..1092899 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1092901) /Source="Nicolas_upshifts" /id="D610" /incds=0 /nref=33 /ntot=166 /MaxReadThrough="1.19008" /MaxDrop="5.22155" /score="16.2777759" /energy="-11.2" /TU="NA" /idTUdmin="U902" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 1092914..1092925 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1092935 /Source="Nicolas_upshifts" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="upshifts" CDS 1092951..1093130 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25859258" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389008.1" /db_xref="EnsemblGenomes-Gn:BSU11260" /db_xref="EnsemblGenomes-Tr:CAB12967" /db_xref="InterPro:IPR025549" /db_xref="SubtiList:BG13223" /db_xref="UniProtKB/Swiss-Prot:O34585" /translation="MGQQHQFRPGQKAPNNGVYVEIGETGSMVKNPQKVHLSAGEMFP ETSNHNRLWTYKRKP*" /label="yjzC CDS" gene 1092951..1093130 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /label="yjzC gene" downshifts 1093140 /Source="Nicolas_upshifts" /id="D611" /incds=0 /nref=19 /ntot=53 /MaxReadThrough="0.25116" /MaxDrop="5.67653" /score="4.8153862" /energy="-10.9" /TU="NA" /idTUdmin="U899" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1093176..1093361) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19775244" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19775244; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore targeted protein" /protein_id="NP_389009.1" /db_xref="EnsemblGenomes-Gn:BSU11270" /db_xref="EnsemblGenomes-Tr:CAB12968" /db_xref="GOA:O34713" /db_xref="InterPro:IPR021324" /db_xref="SubtiList:BG13224" /db_xref="UniProtKB/Swiss-Prot:O34713" /translation="MRYIIAFIWTFLLSHMACYLVASMNSVTYNFKTSSVIAVVLYVL IMVLAEIMPMNKNASQH*" /label="yjzD CDS" gene complement(1093176..1093361) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /label="yjzD gene" downshifts complement(1093187) /Source="Nicolas_upshifts" /id="D612" /incds=0 /nref=215 /ntot=261 /MaxReadThrough="3.91391" /MaxDrop="6.26103" /score="9.62656276" /energy="-10.9" /TU="U902" /idTUdmin="U902" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1093390..1093409) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1093407) /Source="Nicolas_upshifts" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1093420..1093427) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1093462..1093468 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1093480..1093499 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1093485 /Source="Nicolas_upshifts" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1093542..1093551 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1093551 /Source="Nicolas_upshifts" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1093564..1093583 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1093610..1094344 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 18582593" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389010.1" /db_xref="EnsemblGenomes-Gn:BSU11280" /db_xref="EnsemblGenomes-Tr:CAB12969" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13124" /db_xref="UniProtKB/Swiss-Prot:O35001" /translation="MGITERYFQLGTEHNVIHLPYRPNGFGIFILGDRTHFVGHDSSF WQQHYGRNQLLSMLMNEGYTLFNSNLFGRHWGAEKAVTYAKQLIHSVLKQEILNPKIH ILAEGMGALVADELLRFSPDHIRSAAMLNPCLDLQAHYESEKENKFFYKQFLKEVSKS YGISEKEAEAIRYKTIQSYPSGVPVHIWQRMTGAPYPYSVHAEVFKEKQQKQGSPVDM TFHLFEHPSRIYASICKFFHSHEKEL*" /label="yjaU CDS" gene 1093610..1094344 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /label="yjaU gene" S_feature complement(1094103..1094705) /Source="Nicolas_S_feature" /locus_tag="new_1205658_1206260_c" /HighExp="S8, S6, S7, C30, BT, S4, S5, Pyr, S3, C90" /AntisenseName="yjaV" /AntisenseCor="0.66207512383157796" /AntisenseRegPval="-34.6" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.468" /TUlongSig="NA" /TUlongPSig="NA" /label="S400" promotor_-35 1094325..1094330 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1094343 /Source="Nicolas_upshifts" /id="D613" /incds=0 /nref=6 /ntot=47 /MaxReadThrough="5.56163" /MaxDrop="4.5381" /score="1.90624641" /energy="-10" /TU="U904,U905" /idTUdmin="U904" /TUdmin="-945" /isTUend="FALSE" /label="downshifts" upshifts 1094343 /Source="Nicolas_upshifts" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1094346..1094364 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1094426..1094983 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P) binding enzyme" /protein_id="NP_389011.2" /db_xref="EnsemblGenomes-Gn:BSU11290" /db_xref="EnsemblGenomes-Tr:CAB12970" /db_xref="SubtiList:BG13125" /db_xref="UniProtKB/Swiss-Prot:O34959" /translation="MESTLIVGADEFFGLSLCERMMDEGIHVDVVLAETEDKMRQMYL EERLMWLGRNELFRQLEHIGDQNYDTICIQFGSFLPLDQYDSPYILVYEEDRKEWDKR EKTGSEKTVILPKMYGPWKEETEEDGYYTNDVADELLRFLLEPSRHSKDQLFELQVTE KTSKEEAKTKIIEWKRQFSSIFDKY*" /label="yjaV CDS" gene 1094426..1094983 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /label="yjaV gene" promotor_-10 complement(1094685..1094704) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1094705) /Source="Nicolas_upshifts" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1094719..1094723) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1094990..1094997 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1095012..1095031 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1095024 /Source="Nicolas_upshifts" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1095074..1096027 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1203607, 21622736, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1203607, 21622736, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="positive regulator of comK" /protein_id="NP_389012.2" /db_xref="EnsemblGenomes-Gn:BSU11300" /db_xref="EnsemblGenomes-Tr:CAB12971" /db_xref="GOA:O32436" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13126" /db_xref="UniProtKB/Swiss-Prot:O32436" /translation="MITRLVMIFSVLLLLSGCGQTPFKGKIEKVGMLFPDTINDLVWG TKGYKGLLNIQSKYNVDVYYKEGVKTEEDIINAIEDFHKRGVNLLYGHGSEYAEVFNL VGEDYPDMEFVISNAKAKADNVTSVHFSGEAMGFFGGMTAAHMSKTNQVGVIASFTWQ PEVDGFIKGAKYENPDIEVNTKYTDHWDDDTTAVKLYQKMKNEGADVVYPAGDGYNVP VIQQIKKDGLYAIGYVTDQSDLGENTVLTSTVQNVDKAYEIIAEQFNKGTLEGGDHYY DLNTGVVEMGTFSPLVDQDFQQRIAKLIKTYNKTGELPKNE*" /label="med CDS" gene 1095074..1096027 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /label="med gene" promotor_-35 1095691..1095695 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1095711..1095730 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1095724 /Source="Nicolas_upshifts" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1096042..1096233 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10940045; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative late competence gene" /protein_id="NP_389013.1" /db_xref="EnsemblGenomes-Gn:BSU11310" /db_xref="EnsemblGenomes-Tr:CAB12972" /db_xref="GOA:O32437" /db_xref="InterPro:IPR024558" /db_xref="SubtiList:BG13221" /db_xref="UniProtKB/Swiss-Prot:O32437" /translation="MQHEKSLEFLQIAMKYLPEAKEQLEKSGIELSMEAIQPFMNLFT TVMAEAYELGKSDAKSETE*" /label="comZ CDS" gene 1096042..1096233 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /label="comZ gene" downshifts 1096212 /Source="Nicolas_upshifts" /id="D614" /incds=0 /nref=32 /ntot=192 /MaxReadThrough="4.56858" /MaxDrop="3.45953" /score="-7.49795364" /energy="-10.4" /TU="U907,U908" /idTUdmin="U905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1096257..1096597 /Source="Nicolas_S_feature" /locus_tag="new_1207812_1208152" /HighExp="H2O2, C30, G135, Paraq, G180, G150, Oxctl, Cold, dia15, LPh" /AntisenseName="yjzB" /AntisenseCor="-0.34349942363230701" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S401" CDS complement(1096263..1096502) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /experiment="publication(s) with functional evidences, PMID:16391061, 22171814, 27227299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16391061, 22171814, 27227299; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389014.1" /db_xref="EnsemblGenomes-Gn:BSU11320" /db_xref="EnsemblGenomes-Tr:CAB12973" /db_xref="SubtiList:BG13222" /db_xref="UniProtKB/Swiss-Prot:O34891" /translation="MQLDVFSRMMFGDAAKPTEEKEEEQQEEVSQVSQTNDEETINYM HIMDQIGSIMNSLDQIKPALKELAPMLSAIKKKIM*" /label="yjzB CDS" gene complement(1096263..1096502) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /label="yjzB gene" downshifts complement(1096279) /Source="Nicolas_upshifts" /id="D615" /incds=0 /nref=21 /ntot=48 /MaxReadThrough="1.43519" /MaxDrop="5.47891" /score="-7.75082002" /energy="-10.4" /TU="NA" /idTUdmin="U909" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1096515..1096534) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1096536) /Source="Nicolas_upshifts" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1096548..1096557) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1096563..1096570 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1096585..1096604 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1096599 /Source="Nicolas_upshifts" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="upshifts" CDS 1096667..1097605 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 11959561, 21542858, 25196128" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 11959561, 21542858, 25196128; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 1" /protein_id="NP_389015.1" /db_xref="EnsemblGenomes-Gn:BSU11330" /db_xref="EnsemblGenomes-Tr:CAB12974" /db_xref="GOA:O34746" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13127" /db_xref="UniProtKB/Swiss-Prot:O34746" /translation="MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRI AADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVATVTPDQSFPTVSCMIQEQLGAKK ACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDG AGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCV NVIEKAGLSKEDVDFLIPHQANIRIMEAARERLELPVEKMSKTVHKYGNTSAASIPIS LVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR*" /label="fabHA CDS" gene 1096667..1097605 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /label="fabHA gene" promotor_-35 1096744..1096753 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1096762 /Source="Nicolas_upshifts" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1096765..1096780 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1097628..1098869 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /EC_number="2.3.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11325930, 12682299, 16436705, 18384517, 21542858, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325930, 12682299, 16436705, 18384517, 21542858, 28196402; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase II (involved in pimelate synthesis)" /protein_id="NP_389016.1" /db_xref="EnsemblGenomes-Gn:BSU11340" /db_xref="EnsemblGenomes-Tr:CAB12975" /db_xref="GOA:O34340" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR017568" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020841" /db_xref="PDB:4LS5" /db_xref="PDB:4LS6" /db_xref="PDB:4LS7" /db_xref="PDB:4LS8" /db_xref="SubtiList:BG13128" /db_xref="UniProtKB/Swiss-Prot:O34340" /translation="MTKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAE EYPAKVAAELKDFNVEDYMDKKEARKMDRFTQYAVVAAKMAVEDADLNITDEIAPRVG VWVGSGIGGLETLESQFEIFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCT VTACATGTNSIGDAFKVIQRGDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTA SRPFDKNRDGFVMGEGAGIIVLEELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDG EGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSST KSMTGHLLGAAGGIEAIFSILAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYV LSNSLGFGGHNATLIFKKYQS*" /label="fabF CDS" gene 1097628..1098869 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /label="fabF gene" promotor_-10 complement(1097842..1097860) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1097850) /Source="Nicolas_upshifts" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1097876..1097881) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1098720 /Source="Nicolas_upshifts" /id="D616" /incds=1 /nref=1 /ntot=89 /MaxReadThrough="7.03006" /MaxDrop="2.1101" /score="54.6350161" /energy="-18.5" /TU="U910,U911" /idTUdmin="U911" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 1098853 /Source="Nicolas_upshifts" /id="D617" /incds=0 /nref=246 /ntot=274 /MaxReadThrough="0.58964" /MaxDrop="7.80446" /score="54.6350161" /energy="-18.5" /TU="NA" /idTUdmin="U911" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 1098894..1098903 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-35" promotor_-10 1098916..1098935 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-10" upshifts 1098918 /Source="Nicolas_upshifts" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="upshifts" promotor_-35 1098930..1098938 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1098945..1099730 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389017.1" /db_xref="EnsemblGenomes-Gn:BSU11350" /db_xref="EnsemblGenomes-Tr:CAB12992" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13129" /db_xref="UniProtKB/Swiss-Prot:O31596" /translation="MSVEQTYSWLRKAGSIDDLAHYIIPLFSGAEKKNWKGILGHLQH HGMFKNIKEGIQTVSKLKEKGFYGHIQKEEQYLKNKWQGPDVPIVTLPVDERNRRIRL EFGSKSGLAFQDKMFLFLSSDLDFGSVSALMTHEYHHVCRLGHLTKEEKDVTLLDTII MEGLAEYAVYERFGRSQTAEWTTWYTPEQLQALYEKKIAPHRDIKRDNRLFPQLLFGK GYQPKMLGYAVGFNIVKKYLTASKASTADGLSIPAETFLDAML*" /label="yjaZ CDS" gene 1098945..1099730 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /label="yjaZ gene" promotor_-10 1098950..1098968 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1098962 /Source="Nicolas_upshifts" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1099731..1099815 /Source="Nicolas_S_feature" /locus_tag="new_1211286_1211370" /HighExp="S6, S5, S8, S7, BT, S4, S3, B36, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S402" promotor_-10 complement(1099747..1099765) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1099764) /Source="Nicolas_upshifts" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1099780..1099785) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1099783..1099790 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1099805..1099824 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1099817..1099921 /Source="Nicolas_S_feature" /locus_tag="new_1211372_1211476" /HighExp="LoTm, T4.0H, T3.0H, T5.0H, T3.30H, T2.30H, M9-stat, S1, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S403" upshifts 1099817 /Source="Nicolas_upshifts" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1099922..1100908 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389018.1" /db_xref="EnsemblGenomes-Gn:BSU11360" /db_xref="EnsemblGenomes-Tr:CAB12993" /db_xref="GOA:P42064" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11085" /db_xref="UniProtKB/Swiss-Prot:P42064" /translation="MSTLLEVNNLKTYFFRKKEPIPAVDGVDFHISKGETVALVGESG SGKSITSLSIMGLVQSSGGKIMDGSIKLEDKDLTSFTENDYCKIRGNEVSMIFQEPMT SLNPVLTIGEQITEVLIYHKNMKKKEARQRAVELLQMVGFSRAEQIMKEYPHRLSGGM RQRVMIAIALSCNPKLLIADEPTTALDVTIQAQVLELMKDLCQKFNTSILLITHDLGV VSEAADRVIVMYCGQVVENATVDDLFLEPLHPYTEGLLTSIPVIDGEIDKLNAIKGSV PTPDNLPPGCRFAPRCPKAMDKCWTNQPSLLTHKSGRTVRCFLYEEEGAEQS*" /label="appD CDS" gene 1099922..1100908 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /label="appD gene" CDS 1100905..1101894 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389019.2" /db_xref="EnsemblGenomes-Gn:BSU11370" /db_xref="EnsemblGenomes-Tr:CAB12994" /db_xref="GOA:P42065" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11086" /db_xref="UniProtKB/Swiss-Prot:P42065" /translation="MTAANQETILELRDVKKYFPIRSGLFQRKVGDVKAVDGVSFSLK KGETLGIVGESGCGKSTAGRTMIRLYKPTEGQILFKGQDISNLSEEKLRKSVRKNIQM VFQDPFASLNPRKTLRSIIKEPFNTHNMYTMRERNEKVEELLARVGLHPSFAGRYPHE FSGGQRQRIGIARALTLNPELIIADEPVSALDVSIQAQVINLMEELQEEFNLTYLFIS HDLSVVRHISDRVGVMYLGKMMELTGKHELYDNPLHPYTQALLSSVPVTRKRGSVKRE RIVLKGELPSPANPPKGCVFHTRCPVAKPICKEQIPEFKEAAPSHFVACHLYS*" /label="appF CDS" gene 1100905..1101894 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /label="appF gene" misc_feature 1101900..1101906 /Source="Nicolas_upshift_promotors" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1101905..1101981 /Source="Nicolas_S_feature" /locus_tag="new_1213460_1213536" /HighExp="T2.0H, S1, M9-stat, T5.0H, T3.0H, T1.30H, S2, M0t90, T2.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="SigK" /TUlongPSig=1 /label="S404" upshifts 1101905 /Source="Nicolas_upshifts" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1101982..1102473 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15588833, 25355936; Product type rc: receptor" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); N-terminal part of AppA" /translation="MKRRKTALMMLSVLMVLAIFLSACSGSKSSNSSAKKSAGKPQQG GDLVVGSIGEPTLFNSLYSTDDASTDIENMLYSFLTKTDEKLNVKLSLAESIKELDGG LAYDVKIKKGVKFHDGKELTADDVVFTYSVPLSKDYKGERGSTYEMLKSVEKKAITKS CLS*" /label="appAn CDS" gene 1101982..1102473 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /pseudo /label="appAn gene" CDS 1102446..1103612 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7997159, 15588833, 26728191; Product type lp: lipoprotein" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); C-terminal part of AppA" /translation="GDYEVLFKLKYKDGNFYNNALDSTAILPKHILGNVPIADLEENE FNRKKPIGSGPFKFKEWKQGQYIKLEANDDYFEGRPYLDTVTYKVIPDANAAVAQLQA GDINFFNVPATDYKTAEKFNNLKIVTDLALSYVYIGWNEKNELFKDKKVRQALTTALD RESIVSQVLDGDGEVAYIPESPLSWNYPKDIDVPKFEYNEKKAKQMLAEAGWKDTNGD GILDKDGKKFSFTLKTNQGNKVREDIAVVVQEQLKKIGIEVKTQIVEWSALVEQMNPP NWDFDAMVMGWSLSTFPDQYDIFHSSQIKKGLNYVWYKNAEADKLMKDAKSISDRKQY SKEYEQIYQKIAEDQPYTFLYYPNNHMAMPENLEGYKYHPKRDLYNIEKWWLAK*" /label="appAc CDS" gene 1102446..1103612 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /pseudo /label="appAc gene" downshifts 1103603 /Source="Nicolas_upshifts" /id="D618" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="7.71397" /MaxDrop="3.11667" /score="-1.00317393" /energy="-13.3" /TU="U916,U917" /idTUdmin="U913" /TUdmin=1715 /isTUend="FALSE" /label="downshifts" CDS 1103688..1104638 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389021.2" /db_xref="EnsemblGenomes-Gn:BSU11390" /db_xref="EnsemblGenomes-Tr:CAB12996" /db_xref="GOA:P42062" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11088" /db_xref="UniProtKB/Swiss-Prot:P42062" /translation="MAAYIIRRTLMSIPILLGITILSFVIMKAAPGDPMTLMMDPKIS QADREQFIEKYGLNDPQYVQYLKWLGNMVQGDFGTSIVRKGTPVSELIMARLPNTLLL MLVSTILALMISIPFGVLSAKRPYSKIDYGITFTSFIGLAIPNFWFGLILIMVLSVNL GWFPTGGVETLNTEFNIFDRIHHLILPAFVLATADMAGLTRYTRSNMLDVLNQDYIRT ARAKGFKENRVLFKHGLRNALLPVITIFGLMIPSFIGGSVVVEQIFTWPGLGKLFVDS AFQRDYPVIMAMTVISAVLVVVGNLIADILYAIVDPRIEY*" /label="appB CDS" gene 1103688..1104638 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /label="appB gene" CDS 1104655..1105566 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389022.1" /db_xref="EnsemblGenomes-Gn:BSU11400" /db_xref="EnsemblGenomes-Tr:CAB12997" /db_xref="GOA:P42063" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11089" /db_xref="UniProtKB/Swiss-Prot:P42063" /translation="MSELQTTPSPEIRLKENISKKPETMTKIFWEKFSKNKLAILGAV ILFIIIMSAVFAPLIAPYPQEQQSLLDKYKAPGLEHLMGTDKFGRDIFSRILYGARVS LLVGFASVVGSILIGTVLGALAGYFRGIVDAVIMRVVDIVLSIPDIFLLITLVTIFKP GVDKLILIFCLTGWTTTARLVRGEFLSLRSREYVLAAKTIGTKTHKIIFSHILPNALG PIIVSATLKVGSVILAESALSYLGFGIQPPIASWGNMLQDAQNFTVMIQAWWYPLFPG LFILMTVLCFNFVGDGLRDALDPKNIK*" /label="appC CDS" gene 1104655..1105566 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /label="appC gene" downshifts 1105580 /Source="Nicolas_upshifts" /id="D619" /incds=0 /nref=62 /ntot=188 /MaxReadThrough="5.13927" /MaxDrop="5.50153" /score="22.0028545" /energy="-11.6" /TU="U916,U917" /idTUdmin="U916" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" S_feature 1105625..1105732 /Source="Nicolas_S_feature" /locus_tag="new_1217180_1217287" /HighExp="LoTm, S1, S2, BT, T3.30H, T4.0H, T5.0H, T3.0H, Glu, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S405" promotor_-35 1105705..1105710 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1105726..1105744 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1105734 /Source="Nicolas_upshifts" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1105771..1106523 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717292, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation nucleic acid binding protein" /protein_id="NP_389023.1" /db_xref="EnsemblGenomes-Gn:BSU11410" /db_xref="EnsemblGenomes-Tr:CAB12998" /db_xref="InterPro:IPR020909" /db_xref="SubtiList:BG13130" /db_xref="UniProtKB/Swiss-Prot:O31597" /translation="MLFLHDVWVNWFEGEENGYNVCHFHEWRKEDTVELLDQVPLLRV PSVLFHYIENDLSELPKGLLEDVHQKSYIRKNHERTKLEYCFVVTDGIGILAVDTIGY TIPVRKSRLIPRQEQLVYEMVKDVEPETYEFEPKKLESSKEYHILSLAPEHVRGLTRK ERQIKQLMFMALDQLKGLKNRAEIGYWYTEWNPHMYEQIKRMSFEEIWDMLYNETIEG WSDKHLAFCENLIKGQPFFEKLWEMENESKVN*" /label="yjbA CDS" gene 1105771..1106523 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /label="yjbA gene" downshifts 1106503 /Source="Nicolas_upshifts" /id="D620" /incds=0 /nref=32 /ntot=112 /MaxReadThrough="1.07428" /MaxDrop="6.2264" /score="22.0028545" /energy="-11.6" /TU="NA" /idTUdmin="U916" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1106558..1107550) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /EC_number="6.1.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8950174, 10706627, 12682299, 24572018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8950174, 10706627, 12682299, 24572018; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophanyl-tRNA synthetase" /protein_id="NP_389024.1" /db_xref="EnsemblGenomes-Gn:BSU11420" /db_xref="EnsemblGenomes-Tr:CAB12999" /db_xref="GOA:P21656" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002306" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024109" /db_xref="PDB:3PRH" /db_xref="SubtiList:BG10799" /db_xref="UniProtKB/Swiss-Prot:P21656" /translation="MKQTIFSGIQPSGSVTLGNYIGAMKQFVELQHDYNSYFCIVDQH AITVPQDRLELRKNIRNLAALYLAVGLDPEKATLFIQSEVPAHAQAGWMMQCVAYIGE LERMTQFKDKSKGNEAVVSGLLTYPPLMAADILLYGTDLVPVGEDQKQHLELTRNLAE RFNKKYNDIFTIPEVKIPKVGARIMSLNDPLKKMSKSDPNQKAYITLLDEPKQLEKKI KSAVTDSEGIVKFDKENKPGVSNLLTIYSILGNTTIEELEAKYEGKGYGEFKGDLAEV VVNALKPIQDRYYELIESEELDRILDEGAERANRTANKMLKKMENAMGLGRKRR*" /label="trpS CDS" gene complement(1106558..1107550) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /label="trpS gene" downshifts complement(1106579) /Source="Nicolas_upshifts" /id="D621" /incds=0 /nref=224 /ntot=255 /MaxReadThrough="1.77115" /MaxDrop="6.72647" /score="27.6275522" /energy="-11.6" /TU="U919" /idTUdmin="U919" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" misc_RNA complement(1107609..1107823) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /product="T-box riboswitch specific of tryptophan tRNA" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboWA RNA" gene complement(1107609..1107823) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /label="tboWA gene" downshifts complement(1107657) /Source="Nicolas_upshifts" /id="D622" /incds=0 /nref=37 /ntot=127 /MaxReadThrough="6.8472" /MaxDrop="5.13001" /score="25.1445248" /energy="-19" /TU="U919" /idTUdmin="U919" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" misc_feature complement(1107842..1107861) /Source="Nicolas_upshift_promotors" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1107855) /Source="Nicolas_upshifts" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1108110..1108117 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1108131..1108293 /Source="Nicolas_S_feature" /locus_tag="new_1219686_1219848" /HighExp="S1, T3.0H, T3.30H, T2.30H, T4.0H, T5.0H, LoTm, T2.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S406" promotor_-10 1108132..1108151 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1108132 /Source="Nicolas_upshifts" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1108294..1109931 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (binding lipoprotein)" /protein_id="NP_389025.1" /db_xref="EnsemblGenomes-Gn:BSU11430" /db_xref="EnsemblGenomes-Tr:CAB13000" /db_xref="GOA:P24141" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10771" /db_xref="UniProtKB/Swiss-Prot:P24141" /translation="MKKRWSIVTLMLIFTLVLSACGFGGSGSNGEGKKDSKGKTTLNI NIKTEPFSLHPGLANDSVSGGVIRQTFEGLTRINADGEPEEGMASKIETSKDGKTYTF TIRDGVKWSNGDPVTAQDFEYAWKWALDPNNESQYAYQLYYIKGAEAANTGKGSLDDV AVKAVNDKTLKVELNNPTPYFTELTAFYTYMPINKKIAEKNKKWNTNAGDDYVSNGPF KMTAWKHSGSITLEKNDQYWDKDKVKLKKIDMVMINNNNTELKKFQAGELDWAGMPLG QLPTESLPTLKKDGSLHVEPIAGVYWYKFNTEAKPLDNVNIRKALTYSLDRQSIVKNV TQGEQIPAMAAVPPTMKGFEDNKEGYFKDNDVKTAKEYLEKGLKEMGLSKASDLPKIK LSYNTDDAHAKIAQAVQEMWKKNLGVDVELDNSEWNVYIDKLHSQDYQIGRMGWLGDF NDPINFLELFRDKNGGNNDTGWENPEFKKLLNQSQTETDKTKRAELLKKAEGIFIDEM PVAPIYFYTDTWVQDENLKGVIMPGTGEVYFRNAYFK*" /label="oppA CDS" gene 1108294..1109931 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /label="oppA gene" downshifts 1109825 /Source="Nicolas_upshifts" /id="D623" /incds=1 /nref=8 /ntot=166 /MaxReadThrough="6.94127" /MaxDrop="3.3677" /score="-4.2761508" /energy="-15.6" /TU="U920" /idTUdmin="U916" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 1109932..1110038 /Source="Nicolas_S_feature" /locus_tag="new_1221487_1221593" /HighExp="S1, LoTm, T4.0H, BT, T3.30H, T3.0H, T5.0H, M0t90, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S407" CDS 1110039..1110974 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 17600541, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 17600541, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389026.1" /db_xref="EnsemblGenomes-Gn:BSU11440" /db_xref="EnsemblGenomes-Tr:CAB13001" /db_xref="GOA:P24138" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10772" /db_xref="UniProtKB/Swiss-Prot:P24138" /translation="MLKYIGRRLVYMIITLFVIVTVTFFLMQAAPGGPFSGEKKLPPE IEANLNAHYGLDKPLFVQYVSYLKSVAMWDFGPSFKYKGQSVNDLISSGFPVSFTLGA EAILLALALGVLFGVIAALYHNKWQDYTVAILTIFGISVPSFIMAAVLQYVFSMKLGL FPVAGWDSWAYTFLPSIALASMPMAFIARLSRSSMIEVLNSDYIRTAKAKGLSRPAVT VRHAIRNALLPVVTYMGPMAAQVLTGSFIIETIFGIPGLGAHFVNSITNRDYTVIMGV TVFFSVILLLCVLIVDVLYGIIDPRIKLSKAKKGA*" /label="oppB CDS" gene 1110039..1110974 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /label="oppB gene" promotor_-10 complement(1110082..1110101) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1110099) /Source="Nicolas_upshifts" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1110117..1110123) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1110978..1111895 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 26782429" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 26782429; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389027.1" /db_xref="EnsemblGenomes-Gn:BSU11450" /db_xref="EnsemblGenomes-Tr:CAB13002" /db_xref="GOA:P24139" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10773" /db_xref="UniProtKB/Swiss-Prot:P24139" /translation="MQNIPKNMFEPAAANAGDAEKISKKSLSLWKDAMLRFRSNKLAM VGLIIIVLIILMAIFAPMFSRYDYSTTNLLNADKPPSKDHWFGTDDLGRDIFVRTWVG ARISIFIGVAAAVLDLLIGVIWGSISGFRGGRTDEIMMRIADILWAVPSLLMVILLMV VLPKGLFTIIIAMTITGWINMARIVRGQVLQLKNQEYVLASQTLGAKTSRLLFKHIVP NAMGSILVTMTLTVPTAIFTEAFLSYLGLGVPAPLASWGTMASDGLPALTYYPWRLFF PAGFICITMFGFNVVGDGLRDALDPKLRK*" /label="oppC CDS" gene 1110978..1111895 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /label="oppC gene" CDS 1111900..1112976 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 19202088, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 19202088, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389028.1" /db_xref="EnsemblGenomes-Gn:BSU11460" /db_xref="EnsemblGenomes-Tr:CAB13003" /db_xref="GOA:P24136" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10774" /db_xref="UniProtKB/Swiss-Prot:P24136" /translation="MIRVTRLLEVKDLAISFKTYGGEVQAIRGVNFHLDKGETLAIVG ESGSGKSVTSQAIMKLIPMPPGYFKRGEILFEGKDLVPLSEKEMQNVRGKEIGMIFQD PMTSLNPTMKVGKQITEVLFKHEKISKEAAKKRAVELLELVGIPMPEKRVNQFPHEFS GGMRQRVVIAMALAANPKLLIADEPTTALDVTIQAQILELMKDLQKKIDTSIIFITHD LGVVANVADRVAVMYAGQIVETGTVDEIFYDPRHPYTWGLLASMPTLESSGEEELTAI PGTPPDLTNPPKGDAFALRSSYAMKIDFEQEPPMFKVSDTHYVKSWLLHPDAPKVEPP EAVKAKMRKLANTFEKPVLVREVE*" /label="oppD CDS" gene 1111900..1112976 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /label="oppD gene" CDS 1112978..1113895 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 7997159, 11401703, 23133654, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 7997159, 11401703, 23133654, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389029.1" /db_xref="EnsemblGenomes-Gn:BSU11470" /db_xref="EnsemblGenomes-Tr:CAB13004" /db_xref="GOA:P24137" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10775" /db_xref="UniProtKB/Swiss-Prot:P24137" /translation="MTEKLLEIKHLKQHFVTPRGTVKAVDDLSFDIYKGETLGLVGES GCGKSTTGRSIIRLYEATDGEVLFNGENVHGRKSRKKLLEFNRKMQMIFQDPYASLNP RMTVADIIAEGLDIHKLAKTKKERMQRVHELLETVGLNKEHANRYPHEFSGGQRQRIG IARALAVDPEFIIADEPISALDVSIQAQVVNLMKELQKEKGLTYLFIAHDLSMVKYIS DRIGVMYFGKLVELAPADELYENPLHPYTKSLLSAIPLPDPDYERNRVRQKYDPSVHQ LKDGETMEFREVKPGHFVMCTEAEFKAFS*" /label="oppF CDS" gene 1112978..1113895 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /label="oppF gene" downshifts 1113865 /Source="Nicolas_upshifts" /id="D624" /incds=0 /nref=21 /ntot=196 /MaxReadThrough="1.58906" /MaxDrop="5.17491" /score="28.2861081" /energy="-15.2" /TU="NA" /idTUdmin="U920" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 1113945..1113948 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1113961 /Source="Nicolas_upshifts" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1113963..1113982 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1114002..1115219 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563878, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_389030.2" /db_xref="EnsemblGenomes-Gn:BSU11480" /db_xref="EnsemblGenomes-Tr:CAB13005" /db_xref="GOA:O31600" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13131" /db_xref="UniProtKB/Swiss-Prot:O31600" /translation="MQFLHNKNVFALLLSQSFQSLAGVLVTIVLMVRIYQMTDSVFLA GLILSFMSFASIAASFCVSPVLRILGFKKVLAGANLLRAVFIILMAYSVTHHGQAFFW ITLLFVFCFSFAGAFFQPARFALLPIIVPKKQYVKANGVISLSNQLFLTAGWGLGGLL TYAVPFELVVGAAICLFVLSGASISVLHVNEEEAAGTAETASVRSIWKDLMIIPIVRD ITVMDMLEALAGSVWSSAILLAFTAAVLHETEVWWGMFNASYFIGAIVGSVIAIRFSS FFERNMGYAIMFSSLVMSALTLLFSFSPVPFLCALACAAMGPFYQVRDICQETMLQEV IPEQKRIGIMAAKNAILTPWSGVTYSIMGLVADAAGAKIAFIAAAALYIMTFLIALAQ PRLVHYRRENRVQ*" /label="yjbB CDS" gene 1114002..1115219 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /label="yjbB gene" promotor_-35 1115272..1115281 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-35" promotor_-10 1115294..1115309 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-10" S_feature 1115303..1115382 /Source="Nicolas_S_feature" /locus_tag="new_1226858_1226937" /HighExp="Etha, B60, M9-stat, T0.30H, Salt, T3.0H, T1.0H, T4.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S408" upshifts 1115303 /Source="Nicolas_upshifts" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="upshifts" CDS 1115383..1115961 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17158660, 17158663, 21815947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol oxidation management factor; putative acetyltransferase" /protein_id="NP_389031.2" /db_xref="EnsemblGenomes-Gn:BSU11490" /db_xref="EnsemblGenomes-Tr:CAB13006" /db_xref="GOA:O31601" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13132" /db_xref="UniProtKB/Swiss-Prot:O31601" /translation="MNWYEKLSEYFPIEEMKSKAHMEALLKERSDIYHKDEGKHHILM FAEFDSFIFVDYLYVSKDARGQGLGGKLIAKLKKKNKPILLEVEPVDEDDTDTEKRLR FYQREHFKHAQSIGYRRRSLATNEVNKMEILYWSPKTESEEEILEAMKQTYENIHTYK DEKWYGESYEKTDEVLEIIDEEKQKNIFDQLS*" /label="yjbC CDS" gene 1115383..1115961 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /label="yjbC gene" S_feature 1115962..1116076 /Source="Nicolas_S_feature" /locus_tag="new_1227517_1227631" /HighExp="B60, Etha, Salt, T0.30H, M9-stat, LoTm, Gly, T1.0H, B36, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S409" promotor_-10 complement(1116013..1116032) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1116017) /Source="Nicolas_upshifts" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1116046..1116053) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1116079..1116092 /Source="Nicolas_upshift_promotors" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1116079 /Source="Nicolas_upshifts" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="upshifts" CDS 1116142..1116537 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="redox-sensitive regulator" /protein_id="NP_389032.1" /db_xref="EnsemblGenomes-Gn:BSU11500" /db_xref="EnsemblGenomes-Tr:CAB13007" /db_xref="GOA:O31602" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR023731" /db_xref="InterPro:IPR036249" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG13133" /db_xref="UniProtKB/Swiss-Prot:O31602" /translation="MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQ ILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQ VGYNEDEIRRFLPRKVRSFQLREAQRLAN*" /label="spxA CDS" gene 1116142..1116537 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /label="spxA gene" promotor_no_box complement(1116373..1116473) /Source="Nicolas_upshift_promotors" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1116413) /Source="Nicolas_upshifts" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1116535 /Source="Nicolas_upshifts" /id="D625" /incds=0 /nref=263 /ntot=269 /MaxReadThrough="4.34531" /MaxDrop="8.0579" /score="7.42972561" /energy="-8.8" /TU="U923" /idTUdmin="U925" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1116580..1117369 /Source="Nicolas_S_feature" /locus_tag="new_1228135_1228924" /HighExp="B60, B36, Etha, M9-stat, Salt, H2O2, Paraq, Cold, G180, G135" /AntisenseName="yjbE" /AntisenseCor="-0.18634010398760401" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S410" CDS complement(1116580..1117236) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389033.1" /db_xref="EnsemblGenomes-Gn:BSU11510" /db_xref="EnsemblGenomes-Tr:CAB13008" /db_xref="GOA:O31603" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022301" /db_xref="SubtiList:BG13134" /db_xref="UniProtKB/Swiss-Prot:O31603" /translation="MEHDYLISLLVIVGIDLILGGDNAVVIAMASRHLPDKQRQQAII LGTFIAVAMRIGLTSAAVYLLNIPFLQCAGGIFLLYLGYQLLIEKKDTKHIKSSTSLW RAIRTIVLADLFMSLDNVIAVAGASHGEFSLVVIGLCVSVPVIIWGSKLIHIALEKIP LLIYAGSGLLAYTGGEMIVRDKKLSLFMAQHGTVETLLPILTVAFVILASIYYQQVEK *" /label="yjbE CDS" gene complement(1116580..1117236) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /label="yjbE gene" promotor_-10 complement(1117266..1117284) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1117281) /Source="Nicolas_upshifts" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1117299..1117304) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1117342..1117349 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1117363..1117382 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1117371..1117512 /Source="Nicolas_S_feature" /locus_tag="new_1228926_1229067" /HighExp="B60, Diami, Etha, dia5, LPhT, M9-stat, T5.0H, T3.0H, dia15, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S411" upshifts 1117371 /Source="Nicolas_upshifts" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="upshifts" CDS 1117406..1117546 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513949.1" /translation="MVKVKMWTEWVKCSKVQLIGSLDVPSTSYIEGKVGKWKLKELTS IQ*" /label="conserved hypothetical protein CDS" gene 1117406..1117546 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /label="gene" CDS 1117513..1118169 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10361283, 10447896, 16525504, 19801546, 21435029, 23595989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 10447896, 16525504, 19801546, 21435029, 23595989; Product type f : factor" /codon_start=1 /transl_table=11 /product="adaptor protein controlling oligomerization of the AAA+ protein ClpC" /protein_id="NP_389034.1" /db_xref="EnsemblGenomes-Gn:BSU11520" /db_xref="EnsemblGenomes-Tr:CAB13009" /db_xref="GOA:P37958" /db_xref="InterPro:IPR008681" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3JTP" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="SubtiList:BG10680" /db_xref="UniProtKB/Swiss-Prot:P37958" /translation="MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEV MDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASE DLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENR YYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS *" /label="mecA CDS" gene 1117513..1118169 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /label="mecA gene" downshifts 1118159 /Source="Nicolas_upshifts" /id="D626" /incds=0 /nref=120 /ntot=308 /MaxReadThrough="5.41786" /MaxDrop="7.67172" /score="32.2431225" /energy="-11.8" /TU="U928" /idTUdmin="U928" /TUdmin="-774" /isTUend="FALSE" /label="downshifts" CDS complement(1118164..1118286) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513950.1" /translation="MINSCSLYFLLVYMFLIFHISKMAFSCIKKTDFRKEIGLL*" /label="conserved hypothetical protein CDS" gene complement(1118164..1118286) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /label="gene" S_feature 1118204..1118293 /Source="Nicolas_S_feature" /locus_tag="new_1229759_1229848" /HighExp="Etha, M9-stat, B60, dia15, T0.30H, Diami, C30, H2O2, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S412" promotor_-35 1118272..1118280 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1118291..1118309 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1118295..1118359 /Source="Nicolas_S_feature" /locus_tag="new_1229850_1229914" /HighExp="Etha, G/S, GM 150, T-4.40H, S2, T-2.40H, Pyr, C90, M9-tran, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.876, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S413" upshifts 1118295 /Source="Nicolas_upshifts" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1118360..1119481 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10438773, 17630974, 23046409, 26880300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438773, 17630974, 23046409, 26880300; Product type s: structure" /codon_start=1 /transl_table=11 /product="protein involved in establishment of DNA transport in competence" /protein_id="NP_389035.1" /db_xref="EnsemblGenomes-Gn:BSU11530" /db_xref="EnsemblGenomes-Tr:CAB13010" /db_xref="GOA:O31604" /db_xref="InterPro:IPR010330" /db_xref="InterPro:IPR021176" /db_xref="SubtiList:BG13135" /db_xref="UniProtKB/Swiss-Prot:O31604" /translation="MFHLLGAQQNQKLKRRRFFCPVCGGELAVKLGLQKAPHFAHKQN KSCAIDIEPESAYHLEGKRQLYVWLKTQRASPILEPYIRTINQRPDVMARIKEHMLAV EYQCATIAPDVFQKRTEGFKQEGIIPQWIMGYSRLKRTASSFYQLSTFHWQFINASPY RELICYCPERRSFLRLSHIIPFYTNHSYSSVQTIPIHRAGAGDLFFTEPKPSIQYSGW TKAIHRFRHKPHRFNSKETNRLRLLFYEKRQTPFSFLPTEVFVPVRKGAVFKSPVFVW QGFLYLFMTDLGGKRAPIRFSAVLQQCKLHIHNKNIALRSECSEECLSEAVKQYIDFL CKKGFLRETQKEVYVLNQPAGGIHSMQDLIERDRSCFIE*" /label="coiA CDS" gene 1118360..1119481 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /label="coiA gene" promotor_-35 1119135..1119141 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" upshifts 1119153 /Source="Nicolas_upshifts" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-10 1119156..1119174 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" promotor_-35 1119367..1119375 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" promotor_-10 1119387..1119405 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" upshifts 1119394 /Source="Nicolas_upshifts" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-35 1119475..1119481 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1119496..1119507 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1119505 /Source="Nicolas_upshifts" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1119528..1121540 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11741842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11741842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoendopeptidase F" /protein_id="NP_389036.2" /db_xref="EnsemblGenomes-Gn:BSU11540" /db_xref="EnsemblGenomes-Tr:CAB13011" /db_xref="GOA:O31605" /db_xref="InterPro:IPR001567" /db_xref="InterPro:IPR004438" /db_xref="InterPro:IPR013647" /db_xref="SubtiList:BG13136" /db_xref="UniProtKB/Swiss-Prot:O31605" /translation="MKGTKGKVFRVFTAFLAFVLFITAYDLTKGSEKPEDIHNTSLLR NSCFFNWLESKKTRGITMAEEKKANQLPDRSEVKAEDTWRLEDIFPSDEAWNKEFQAV KELIPNLSKYKGKLADSADHLYEALTYQDKVMERLGRLYTYAHMRSDQDTGNSFYQGL NDKAGNLYTQAASATAYLVPEILSIEEDKLQQFILEKEELKLYSHAIEEITKERPHVL SEKEEALLAEASEVLGSSSNTFSVLNNADITFPSIKDEDGNEKQITHGNFINFLESEN REVRKNAFDAVYKTYGQYKNTMATTLSGTVKKDNFYARVKKYKSAREAALSNNSIPEE VYDNLVKTINKHLPLLHRYIALRKKVLELDEVHIYDLYTPLVKDAGMKVTYEEAKDYM LKGLAPLGEEYASILKEGLENRWVDVYENKGKRNGAYSSGAYGTNPYILMNWHNNVNN LFTLVHEFGHSVHSYYTRKHQPYPYGNYSIFVAEVASTTNEALLGEYLLNNLEDEKQR LYILNHMLEGFRGTVFRQTMFAEFEHLIHTKAQEGEPLTPELLTNVYYDLNKKYFGDG MVIDKEIGLEWSRIPHFYYNYYVYQYATGYSAAQALSSQILKEGKPAVDRYIDFLKAG SSQYPIDVLKKAGVDMTSPEPIEAACKMFEEKLDEMEELLMKVKQS*" /label="pepF CDS" gene 1119528..1121540 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /label="pepF gene" promotor_-35 1119603..1119610 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-35" promotor_-10 1119625..1119644 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-10" upshifts 1119637 /Source="Nicolas_upshifts" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="upshifts" downshifts 1121487 /Source="Nicolas_upshifts" /id="D627" /incds=0 /nref=98 /ntot=339 /MaxReadThrough="4.70576" /MaxDrop="5.74441" /score="19.0969124" /energy="-15.2" /TU="U933" /idTUdmin="U931" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 1121541..1121842 /Source="Nicolas_S_feature" /locus_tag="new_1233096_1233397" /HighExp="Etha, dia15, Diami, B60, M9-stat, S8, M0t90, dia5, B36, T0.30H" /AntisenseName="yizD" /AntisenseCor="-1.29003203536192E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="SigH, SigB" /TUlongPSig="0.999, 0.999" /label="S414" CDS complement(1121578..1121745) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097703.1" /db_xref="EnsemblGenomes-Gn:BSU11549" /db_xref="EnsemblGenomes-Tr:CAX52593" /db_xref="GOA:C0H3Y6" /db_xref="UniProtKB/Swiss-Prot:C0H3Y6" /translation="MMSTLISIVCIAVFFCLNILGMMHMLPLYITSPLLFLSILFTLY RLNHRKTFKGF*" /label="yizD CDS" gene complement(1121578..1121745) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /label="yizD gene" downshifts complement(1121591) /Source="Nicolas_upshifts" /id="D628" /incds=0 /nref=8 /ntot=61 /MaxReadThrough="1.527" /MaxDrop="5.54041" /score="-4.56163992" /energy="-15.2" /TU="NA" /idTUdmin="U934" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1121765..1121783) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1121781) /Source="Nicolas_upshifts" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1121799..1121804) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1121835..1121842 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1121844..1121969 /Source="Nicolas_S_feature" /locus_tag="new_1233399_1233524" /HighExp="B36, T-1.10H, nit, T-0.40H, M9-tran, LoTm, Pyr, Etha, Salt, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.883" /TUlongSig="SigA, SigH, SigB" /TUlongPSig="0.926, 0.999, 0.999" /label="S415" upshifts 1121844 /Source="Nicolas_upshifts" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1121850..1121988 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /product="small regulatory RNA (NO regulated)" /experiment="publication(s) with functional evidences, PMID:19682248, 19786493, 20511587, 20525796, 25643072, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682248, 19786493, 20511587, 20525796, 25643072, 28436820; Product type n : RNA" /label="roxS RNA" gene 1121850..1121988 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /label="roxS gene" promotor_-10 1121857..1121876 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1121926 /Source="Nicolas_upshifts" /id="D629" /incds=0 /nref=96 /ntot=135 /MaxReadThrough="3.50613" /MaxDrop="9.07209" /score="5.30186633" /energy="-11.6" /TU="U935" /idTUdmin="U933" /TUdmin=89 /isTUend="FALSE" /label="downshifts" CDS complement(1122059..1122958) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiol management effector of SpxA degradation" /protein_id="NP_389037.2" /db_xref="EnsemblGenomes-Gn:BSU11550" /db_xref="EnsemblGenomes-Tr:CAB13012" /db_xref="GOA:O31606" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13137" /db_xref="UniProtKB/Swiss-Prot:O31606" /translation="MTNYQHELYFAHCHGHPKKPLEIYMFVDPLCPECWSLEPVIKKL KIRYGRFFTLRIIASASLTALNKKRKKHLLAEAWEKIASRSGMSCDGNVWFEQDQPLS SPYMAALAFKAAELQGRKAGMQFLRNMQESLFVSKKNITDENVLLEIAENTSLDLEEF KKDLHSQSAVKALQCDMKIAAEMDVSVNPTLTFFNTQHEDEGLKVPGSYSYDVYEEIL FEMLGDEPKPSETPPLECFIEYFRFVASKEIALVYDLSLEEVEKEMKKLAFAKKVAKV EAKHGMFWKSLSTYSDEYQSCEK*" /label="spxH CDS" gene complement(1122059..1122958) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /label="spxH gene" downshifts complement(1122090) /Source="Nicolas_upshifts" /id="D630" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="3.70729" /MaxDrop="5.65601" /score="17.9327625" /energy="-13.3" /TU="U937" /idTUdmin="U937" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1122294..1122299 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1122306 /Source="Nicolas_upshifts" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1122315..1122333 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1122322..1124223 /Source="Nicolas_S_feature" /locus_tag="new_1233877_1235778" /HighExp="S6, S4, S5, S8, S3, S7, BT, B36, C30, T5.0H" /AntisenseName="yjbH" /AntisenseCor="-0.61019541931037402" /AntisenseRegPval="-28.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S416" CDS complement(1122955..1123353) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15866723, 17293416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol management oxidoreductase component" /protein_id="NP_389038.1" /db_xref="EnsemblGenomes-Gn:BSU11560" /db_xref="EnsemblGenomes-Tr:CAB13013" /db_xref="GOA:O31607" /db_xref="InterPro:IPR001486" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR019795" /db_xref="PDB:1UX8" /db_xref="SubtiList:BG13138" /db_xref="UniProtKB/Swiss-Prot:O31607" /translation="MGQSFNAPYEAIGEELLSQLVDTFYERVASHPLLKPIFPSDLTE TARKQKQFLTQYLGGPPLYTEEHGHPMLRARHLPFPITNERADAWLSCMKDAMDHVGL EGEIREFLFGRLELTARHMVNQTEAEDRSS*" /label="yjbI CDS" gene complement(1122955..1123353) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /label="yjbI gene" S_feature complement(1123354..1123533) /Source="Nicolas_S_feature" /locus_tag="new_1234909_1235088_c" /HighExp="Diami, dia5, dia15, Etha, H2O2, C90, LoTm, Heat, Salt, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.999" /label="S417" promotor_-10 complement(1123525..1123544) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1123533) /Source="Nicolas_upshifts" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1123556..1123563) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1123608..1124153) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /EC_number="3.2.1.-" /EC_number="3.2.1.17" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:20609359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20609359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional muramidase and murein lytic transglycosylase" /protein_id="NP_389039.1" /db_xref="EnsemblGenomes-Gn:BSU11570" /db_xref="EnsemblGenomes-Tr:CAB13014" /db_xref="GOA:O31608" /db_xref="InterPro:IPR000189" /db_xref="InterPro:IPR008258" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13139" /db_xref="UniProtKB/Swiss-Prot:O31608" /translation="MLNSANTTAPSLLSAYGLNSYTSSNSGSVTKAAESTETAVADSA SNKHEANQIRSGDFSIDSAIKKAADKYGVDEKLIRAVIKQESGFNAKAVSGAGAMGLM QLMPSTASSLGVSNPLDPQQNVEGGTKYLKQMLDKYDGNVSMALAAYNAGPGNVDRYG GIPPFQETQNYVKKITSVYYA*" /label="cwlQ CDS" gene complement(1123608..1124153) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /label="cwlQ gene" downshifts complement(1123632) /Source="Nicolas_upshifts" /id="D631" /incds=0 /nref=101 /ntot=222 /MaxReadThrough="4.1014" /MaxDrop="5.00847" /score="6.97790581" /energy="-9.1" /TU="U938,U939" /idTUdmin="U938" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" S_feature complement(1124154..1124356) /Source="Nicolas_S_feature" /locus_tag="new_1235709_1235911_c" /HighExp="T0.30H, Gly, C90, GM 10, GM 45, M0t90, Lbstat, C30, Lbtran, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S418" CDS complement(1124357..1124929) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9642185, 12456267, 16905149, 20509597, 26904951, 27881678; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative RNA/thiamine triphosphatase" /protein_id="NP_389040.1" /db_xref="EnsemblGenomes-Gn:BSU11580" /db_xref="EnsemblGenomes-Tr:CAB13015" /db_xref="GOA:O31609" /db_xref="InterPro:IPR009195" /db_xref="InterPro:IPR023577" /db_xref="InterPro:IPR033469" /db_xref="SubtiList:BG13140" /db_xref="UniProtKB/Swiss-Prot:O31609" /translation="MSQEIEIEFKNMLTKQEFKNIASALQLTEKDFTDQKNHYFDTDS FALKQKHAALRIRRKNGKYVLTLKEPADVGLLETHQQLSEVSDLAGFSVPEGPVKDQL HKLQIDTDAIQYFGSLATNRAEKETEKGLIVLDHSRYLNKEDYEIEFEAADWHEGRQA FEKLLQQFSIPQRETKNKILRFYEEKRKSI*" /label="yjbK CDS" gene complement(1124357..1124929) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /label="yjbK gene" promotor_-10 complement(1124502..1124520) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1124511) /Source="Nicolas_upshifts" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 complement(1124533..1124540) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" promotor_-10 complement(1124958..1124977) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1124975) /Source="Nicolas_upshifts" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 1124991..1124994 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1124992..1124999) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" upshifts 1125007 /Source="Nicolas_upshifts" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1125010..1125029 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1125054..1125422 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389041.1" /db_xref="EnsemblGenomes-Gn:BSU11590" /db_xref="EnsemblGenomes-Tr:CAB13016" /db_xref="InterPro:IPR020908" /db_xref="SubtiList:BG13141" /db_xref="UniProtKB/Swiss-Prot:O31610" /translation="MQNRIEILNATLSDDQLRLACQTEGNEAERKPSGQMLVDSDHFA FVYILELADSFEYVIIKEHVWPELKQAHAQKIPVVLEAGDQTIELAGLHEELEYLLEN IKDNANYGEEMEEKVKRVFL*" /label="yjbL CDS" gene 1125054..1125422 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /label="yjbL gene" CDS 1125451..1126086 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /EC_number="2.7.6.5" /function="16.1: Circulate" /function="16.14: Store" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 24163341, 25331430, 26825398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 24163341, 25331430, 26825398; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_389042.1" /db_xref="EnsemblGenomes-Gn:BSU11600" /db_xref="EnsemblGenomes-Tr:CAB13017" /db_xref="GOA:O31611" /db_xref="InterPro:IPR007685" /db_xref="PDB:5DEC" /db_xref="PDB:5DED" /db_xref="PDB:5F2V" /db_xref="SubtiList:BG13142" /db_xref="UniProtKB/Swiss-Prot:O31611" /translation="MDDKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVT GRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVV DQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYK YSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEAQAAFSRKKKGSEQQ*" /label="relP CDS" gene 1125451..1126086 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /label="relP gene" CDS 1126105..1126905 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /EC_number="2.7.1.23" /function="16.14: Store" /function="16.7: Manage energy" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12897004, 16233726, 16511117, 18720024, 24048943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12897004, 16233726, 16511117, 18720024, 24048943; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase (quinolate activated)" /protein_id="NP_389043.1" /db_xref="EnsemblGenomes-Gn:BSU11610" /db_xref="EnsemblGenomes-Tr:CAB13018" /db_xref="GOA:O31612" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13143" /db_xref="UniProtKB/Swiss-Prot:O31612" /translation="MKFAVSSKGDQVSDTLKSKIQAYLLDFDMELDENEPEIVISVGG DGTLLYAFHRYSDRLDKTAFVGVHTGHLGFYADWVPHEIEKLVLAIAKTPYHTVEYPL LEVIVTYHENEREERYLALNECTIKSIEGSLVADVEIKGQLFETFRGDGLCLSTPSGS TAYNKALGGAIIHPSIRAIQLAEMASINNRVFRTVGSPLLLPSHHDCMIKPRNEVDFQ VTIDHLTLLHKDVKSIRCQVASEKVRFARFRPFPFWKRVQDSFIGKGE*" /label="ppnKA CDS" gene 1126105..1126905 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /label="ppnKA gene" CDS 1126968..1127819 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /EC_number="5.4.99.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389044.1" /db_xref="EnsemblGenomes-Gn:BSU11620" /db_xref="EnsemblGenomes-Tr:CAB13019" /db_xref="GOA:O31613" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG13144" /db_xref="UniProtKB/Swiss-Prot:O31613" /translation="MTVKEYAGELGISKRLLTDIKFGGGDLQINGEHVTVKYVLKEGD LLIVKFPEEQVSETLLAEPVPLDILYEDEHVLVINKQPYVSSIPSREHPSGSIANGII DHYQTTGVRATVHLVTRLDRDTSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGR MAQMEGTVDAPIGRHPDSIIERTVTPDGQKAVTHFYVTCANDDMTSVALQLETGRTHQ IRVHMSYLGHPLCGDTLYGGTRQEIGRQALHSEHLSFIHPLTQENMRFHAPLPQDMSK LIKGENH*" /label="yjbO CDS" gene 1126968..1127819 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /label="yjbO gene" downshifts 1127778 /Source="Nicolas_upshifts" /id="D632" /incds=0 /nref=203 /ntot=256 /MaxReadThrough="0.25796" /MaxDrop="5.73002" /score="21.4914497" /energy="-12.8" /TU="NA" /idTUdmin="U940" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1127832..1128566) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /EC_number="3.6.1.17" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12059787, 16740944, 21092197, 23824080, 28516732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12059787, 16740944, 21092197, 23824080, 28516732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphorylated protein phosphatase E and diadenosine-polyphosphate hydrolase" /protein_id="NP_389045.1" /db_xref="EnsemblGenomes-Gn:BSU11630" /db_xref="EnsemblGenomes-Tr:CAB13020" /db_xref="GOA:O31614" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR023937" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13145" /db_xref="UniProtKB/Swiss-Prot:O31614" /translation="MAYDIISDIHGCYDEMTALIQKLGYTIKNGVPVHEEGRVLVFAG DLTDRGPKSIEVIRFVAGAYEKGAVRYVPGNHCNKLYRYLKGNPVKVMHGLETTAAEL EELSKDEKKSVSEQFMKLYETAPLYDILHNGELVVAHAGIRADDIGKYTRRVKDFVLY GDVTGETYPDGRPIRRDWAAAYNGKAWVVYGHTPVKEPRKVNRTINIDTGCVFGNQLT GFRFPEIETVSVPSSLPYDESRFRPI*" /label="prpE CDS" gene complement(1127832..1128566) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /label="prpE gene" downshifts complement(1127854) /Source="Nicolas_upshifts" /id="D633" /incds=0 /nref=22 /ntot=152 /MaxReadThrough="1.18091" /MaxDrop="3.57735" /score="3.24324561" /energy="-12.8" /TU="NA" /idTUdmin="U938" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" promotor_-35 1128688..1128692 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-35" promotor_-10 1128709..1128728 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-10" upshifts 1128723 /Source="Nicolas_upshifts" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="upshifts" S_feature 1128724..1128800 /Source="Nicolas_S_feature" /locus_tag="new_1240279_1240355" /HighExp="H2O2, Diami, dia15, Paraq, Oxctl, Heat, G180, Salt, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S419" CDS 1128801..1130645 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 21742892, 24330391; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gated K+/H+ antiporter" /protein_id="NP_389046.1" /db_xref="EnsemblGenomes-Gn:BSU11640" /db_xref="EnsemblGenomes-Tr:CAB13021" /db_xref="GOA:O31615" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13146" /db_xref="UniProtKB/Swiss-Prot:O31615" /translation="MAHTSVASLVVVLIVAFLTPILLHRFKLSIPVVVAEIIMGLIIG KSGLNLVVEGDTWLQTLSMLGFIFLMFLSGLEIDFSSFEKGKKKQFLPNGKEAPNTFA AASVIFVGIFILSLLLSYGFVLAGFIQNAFLMTLIISTISLGVVVPTLKEERIMNSNI GQIILLVAVIADLATMILLAVFSSLYGEDSGNMWLLMILFAAGVVLYFFGRVFKHRSF VQSMSKGTIQIGTRAIFTLIIVLVALSESLGAENILGAFLAGVLVSLLSPNKELVQQL DSFGYGFLIPIFFVMVGVKLDIWTLFQDKTILIMIPLLLLALLVSKIIPVMYLKKWYD NRTIFASGFLLTSTLSLVIAAATIGQQLHVISTNMSGALILVAVIASIFTPICFKKLY KREEQPEEKKTITFIGANQMTLPVTLELPEEEYDVRVVHVYQENAEEKLSESVFAVET ISDYEHETLESLGIFETDILVVATGNEDMNADIALLAKDKGTERVIASVGSPEHEAAL KEQGISIFSILLSTKTLLRALIEAPGVMKLLTNQESSLYQINMENSKYDGVILREFPL TGDVIFVRIFRGVDSIVPHGDTRLKLGDRLIVTGSRGYVTDLKKTLEG*" /label="kefQ CDS" gene 1128801..1130645 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /label="kefQ gene" misc_feature complement(1129128..1129147) /Source="Nicolas_upshift_promotors" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1129152) /Source="Nicolas_upshifts" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1130647..1130654 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-35" promotor_-10 1130668..1130687 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-10" upshifts 1130674 /Source="Nicolas_upshifts" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="upshifts" misc_RNA 1130707..1130815 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswA RNA" gene 1130707..1130815 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /label="tswA gene" downshifts 1130810 /Source="Nicolas_upshifts" /id="D634" /incds=0 /nref=20 /ntot=84 /MaxReadThrough="7.67021" /MaxDrop="5.27759" /score="34.8346124" /energy="-12.5" /TU="U943" /idTUdmin="U941" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS 1130894..1131604 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /EC_number="3.5.99.2" /function="4.11: Thiamine" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 17618314, 18054064, 24311574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 17618314, 18054064, 24311574; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiaminase II" /protein_id="NP_389047.1" /db_xref="EnsemblGenomes-Gn:BSU11650" /db_xref="EnsemblGenomes-Tr:CAB13022" /db_xref="GOA:P25052" /db_xref="InterPro:IPR004305" /db_xref="InterPro:IPR016084" /db_xref="InterPro:IPR027574" /db_xref="PDB:1TO9" /db_xref="PDB:1TYH" /db_xref="PDB:1YAF" /db_xref="PDB:1YAK" /db_xref="PDB:2QCX" /db_xref="SubtiList:BG10791" /db_xref="UniProtKB/Swiss-Prot:P25052" /translation="MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQD SYYLTHFAKVQSFGAAYAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKA FKPSPTAYSYTSHMYRSVLSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWI GTYGGDWFRQQVEEQINRFDELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGW SDSAIKEVEECGASRHNG*" /label="tenA CDS" gene 1130894..1131604 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /label="tenA gene" CDS 1131579..1132196 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /EC_number="5.3.99.10" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 21534620" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 21534620; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiazole tautomerase" /protein_id="NP_389048.1" /db_xref="EnsemblGenomes-Gn:BSU11660" /db_xref="EnsemblGenomes-Tr:CAB13023" /db_xref="GOA:P25053" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR036206" /db_xref="PDB:1YAD" /db_xref="PDB:3QH2" /db_xref="SubtiList:BG10792" /db_xref="UniProtKB/Swiss-Prot:P25053" /translation="MELHAITDDSKPVEELARIIITIQNEVDFIHIRERSKSAADILK LLDLIFEGGIDKRKLVMNGRVDIALFSTIHRVQLPSGSFSPKQIRARFPHLHIGRSVH SLEEAVQAEKEDADYVLFGHVFETDCKKGLEGRGVSLLSDIKQRISIPVIAIGGMTPD RLRDVKQAGADGIAVMSGIFSSAEPLEAARRYSRKLKEMRYEKAL*" /label="tenI CDS" gene 1131579..1132196 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /label="tenI gene" CDS 1132180..1133289 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /EC_number="1.4.3.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9827558, 11744710, 12627963, 15105420, 19751796, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9827558, 11744710, 12627963, 15105420, 19751796, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="FAD-dependent glycine oxidase" /protein_id="NP_389049.1" /db_xref="EnsemblGenomes-Gn:BSU11670" /db_xref="EnsemblGenomes-Tr:CAB13024" /db_xref="GOA:O31616" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR012727" /db_xref="InterPro:IPR036188" /db_xref="PDB:1NG3" /db_xref="PDB:1NG4" /db_xref="PDB:1RYI" /db_xref="PDB:3IF9" /db_xref="SubtiList:BG13147" /db_xref="UniProtKB/Swiss-Prot:O31616" /translation="MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTS AAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSE EDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKA AKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNA FLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLE SVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILL APATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI*" /label="thiO CDS" gene 1132180..1133289 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /label="thiO gene" CDS 1133289..1133489 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 14567704, 14757766, 15489164, 22616866, 26443755; Product type c : carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier for synthesis of hydroxyethylthiazole phosphate" /protein_id="NP_389050.1" /db_xref="EnsemblGenomes-Gn:BSU11680" /db_xref="EnsemblGenomes-Tr:CAB13025" /db_xref="GOA:O31617" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010035" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="PDB:1TYG" /db_xref="SubtiList:BG13148" /db_xref="UniProtKB/Swiss-Prot:O31617" /translation="MLQLNGKDVKWKKDTGTIQDLLASYQLENKIVIVERNKEIIGKE RYHEVELCDRDVIEIVHFVGGG*" /label="thiS CDS" gene 1133289..1133489 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /label="thiS gene" CDS 1133486..1134256 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /EC_number="2.8.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14567704, 14757766, 15489164, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14567704, 14757766, 15489164, 22938038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="hydroxyethylthiazole phosphate synthetase (thiamine biosynthesis)" /protein_id="NP_389051.1" /db_xref="EnsemblGenomes-Gn:BSU11690" /db_xref="EnsemblGenomes-Tr:CAB13026" /db_xref="GOA:O31618" /db_xref="InterPro:IPR008867" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033983" /db_xref="PDB:1TYG" /db_xref="PDB:1XM3" /db_xref="SubtiList:BG13149" /db_xref="UniProtKB/Swiss-Prot:O31618" /translation="MSMLTIGGKSFQSRLLLGTGKYPSFDIQKEAVAVSESDILTFAV RRMNIFEASQPNFLEQLDLSKYTLLPNTAGASTAEEAVRIARLAKASGLCDMIKVEVI GCSRSLLPDPVETLKASEQLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGS GQGILNPLNLSFIIEQAKVPVIVDAGIGSPKDAAYAMELGADGVLLNTAVSGADDPVK MARAMKLAVEAGRLSYEAGRIPLKQYGTASSPGEGLPV*" /label="thiG CDS" gene 1133486..1134256 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /label="thiG gene" CDS 1134253..1135263 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /EC_number="2.7.7.73" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14567704, 14757766, 15489164, 16388576, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14567704, 14757766, 15489164, 16388576, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate transferase and sulfur transferase (thiamine biosynthesis)" /protein_id="NP_389052.1" /db_xref="EnsemblGenomes-Gn:BSU11700" /db_xref="EnsemblGenomes-Tr:CAB13027" /db_xref="GOA:O31619" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13150" /db_xref="UniProtKB/Swiss-Prot:O31619" /translation="MTGRYSRQELFAPIGPSGQKKLKEARAVIIGAGALGTASAEMLV RAGVGSVKIADRDYVEWSNLQRQQLYTEDDVKKEMPKAAAAERRLRSINSDVDVTGLV MDVTAENIFELIRDASIIVDAADNFETRLIVNDAAVKEGIPFLYGACVGSYGLTFTVV PGSTPCLHCLLDALPIGGATCDTAGIISPAVLQVAVFQVTDALKLLTGEECEPVLRSF DLWKNERSEVRAASLKHDACPSCGTKDFPFLSYENQTKAAVLCGRNTVQIRSSITKEA DLEALAGQLRQAGLEVAANPYLISCRSDDMKMVLFRDGRALIHGTNDIARAKSIYHKW IG*" /label="thiF CDS" gene 1134253..1135263 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /label="thiF gene" CDS 1135282..1136097 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /EC_number="2.7.4.7" /EC_number="2.7.1.49" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14973012, 16952958, 17012797, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14973012, 16952958, 17012797, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase" /protein_id="NP_389053.1" /db_xref="EnsemblGenomes-Gn:BSU11710" /db_xref="EnsemblGenomes-Tr:CAB13028" /db_xref="GOA:O31620" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13151" /db_xref="UniProtKB/Swiss-Prot:O31620" /translation="MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQ NTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRV IVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKA AEQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAA LTAQTAKGDSIHQAFEVAANFVREAVENTLGIGSGHGPTNHFAFKRNSLNTSR*" /label="thiD CDS" gene 1135282..1136097 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /label="thiD gene" downshifts 1136071 /Source="Nicolas_upshifts" /id="D635" /incds=0 /nref=128 /ntot=172 /MaxReadThrough="3.33485" /MaxDrop="5.0154" /score="3.40314581" /energy="-14.8" /TU="U943" /idTUdmin="U943" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1136144..1136150 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1136163..1136182 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1136173 /Source="Nicolas_upshifts" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="upshifts" CDS 1136233..1137009 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /EC_number="1.3.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 15105103, 21185310, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 15105103, 21185310, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase" /protein_id="NP_389054.2" /db_xref="EnsemblGenomes-Gn:BSU11720" /db_xref="EnsemblGenomes-Tr:CAB13029" /db_xref="GOA:P54616" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR014358" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIF" /db_xref="PDB:3OIG" /db_xref="SubtiList:BG13152" /db_xref="UniProtKB/Swiss-Prot:P54616" /translation="MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGER LEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEE LVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNV MGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPL RRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR*" /label="fabI CDS" gene 1136233..1137009 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /label="fabI gene" downshifts 1136998 /Source="Nicolas_upshifts" /id="D636" /incds=0 /nref=229 /ntot=313 /MaxReadThrough="3.12901" /MaxDrop="6.64182" /score="33.5478109" /energy="-11.8" /TU="U944" /idTUdmin="U944" /TUdmin="-416" /isTUend="FALSE" /label="downshifts" SCAR 1137013..1137014 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_009" S_feature <1137014..1138074 /Source="Nicolas_S_feature" /locus_tag="new_1253669_1254769" /HighExp="S8, S6, S7, B36, S5, C30, BT, dia15, Diami, H2O2" /AntisenseName="yjcD" /AntisenseCor="-0.210610370451118" /AntisenseRegPval="-3.3" /CDS_PredictionProba="0.18426200000000001" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S425" CDS complement(1137018..1139297) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544244, 16014871, 17114254, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent DNA helicase (sporulationassociated)" /protein_id="NP_389064.3" /db_xref="EnsemblGenomes-Gn:BSU11820" /db_xref="EnsemblGenomes-Tr:CAB13039" /db_xref="GOA:O31626" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG13157" /db_xref="UniProtKB/Swiss-Prot:O31626" /translation="MKCARLNDRIIHLHTYSREHYQFLFEEGIKGHLFCSHCGKPVLL RLNIADPPEFIHRQPGDFPACEEACEPKPSKEGKKEDDQESGVIRLPKGKAIAADPSP AVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGLNTDQLKAVTETEGPLLVLAGAGSG KTRVLTARAAHMIEHLGIPPENMLLVTFTTKAVAEMKERMANQYGLQPAKVRRIVTGT FHSLFYKILYHSNSAKWNGEHLLKMEWQREQYIKKALYEEGIDEKESPVDQALQQIGF WKNTYVPNERIPLKDEWEKQVYRLYEHYERQKKEHSQFDFDDMASACYELFIERPDLL EQYQSRFTYILIDEFQDINPVQYKIMQMLASPEQNLCCVGDDDQSIYAFRGSNPSFIL DFQKDYPGAKTIYLTANYRSTHPIVSSADIVVKKNKNRYAKTLEAARDDIQVPVLFYP YDEEEEATMVVSDIKEKIQNGASPEDFAVLYRTNSGGRAIYERLHQSSIPYTADRGVQ SFYSRRIVRQILAYLYASQNEDDTEAIKHLLPALFLKQSALNTLKALSITEDCTMIKA LAKLPDLKPFQLDKIKKIVPFFASLRTMKPVEAITFAEGKMGFSEYLKKRGNEGNKLE KGSDDLRDIKVVAKKFKTIPDFLAHVDHMRAAEKNRTDEHGVQLMTIHRSKGLEFKTV YVLGTVDGSIPHDFSLETARKGDEAALEEERRLLYVAMTRAKQHLYLSCPANRRGKTA NRSRFLYPLLQKARQPLHH*" /label="yjcD CDS" gene complement(1137018..1139297) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /label="yjcD gene" downshifts complement(1137036) /Source="Nicolas_upshifts" /id="D648" /incds=0 /nref=61 /ntot=171 /MaxReadThrough="2.59869" /MaxDrop="4.36061" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1139172..1139346) /Source="Nicolas_S_feature" /locus_tag="new_1255867_1256041_c" /HighExp="G180, G135, G150, H2O2, Paraq, Oxctl, LBGexp, dia15, dia0, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S426" promotor_-35 1139225..1139233 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1139244..1139262 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1139248..1139383 /Source="Nicolas_S_feature" /locus_tag="new_1255943_1256078" /HighExp="S4, S5, S3, S6, S7, S8, M9-stat, T4.0H, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S427" upshifts 1139248 /Source="Nicolas_upshifts" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1139334..1139353) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1139345) /Source="Nicolas_upshifts" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1139361..1139367 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1139369..1139373) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1139382..1139400 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1139385 /Source="Nicolas_upshifts" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1139414..1139668 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11976315, 23155385" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097706.1" /db_xref="EnsemblGenomes-Gn:BSU11839" /db_xref="EnsemblGenomes-Tr:CAX52596" /db_xref="UniProtKB/Swiss-Prot:C0H3Y9" /translation="MIYAGQIQNQQYAQYANRTIGHKQDYAGTEKISYVPFQRVYKEL EKQQENQTAAERKVNEMKRKRSLYKRLREKGMGTYINRYV*" /label="yjzE CDS" gene 1139414..1139668 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /label="yjzE gene" downshifts 1139644 /Source="Nicolas_upshifts" /id="D649" /incds=0 /nref=101 /ntot=248 /MaxReadThrough="3.69482" /MaxDrop="7.80206" /score="5.37568515" /energy="-6.1" /TU="U962" /idTUdmin="U960" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1139734) /Source="Nicolas_upshifts" /id="D650" /incds=0 /nref=78 /ntot=283 /MaxReadThrough="3.21062" /MaxDrop="7.8562" /score="-4.05705392" /energy="-6.1" /TU="U963" /idTUdmin="U963" /TUdmin="-36" /isTUend="FALSE" /label="downshifts" CDS complement(1139741..1140163) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389066.1" /db_xref="EnsemblGenomes-Gn:BSU11840" /db_xref="EnsemblGenomes-Tr:CAB13041" /db_xref="GOA:O31628" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1Q2Y" /db_xref="SubtiList:BG13159" /db_xref="UniProtKB/Swiss-Prot:O31628" /translation="MKAVIAKNEEQLKDAFYVREEVFVKEQNVPAEEEIDELENESEH IVVYDGEKPVGAGRWRMKDGYGKLERICVLKSHRSAGVGGIIMKALEKAAADGGASGF ILNAQTQAVPFYKKHGYRVLSEKEFLDAGIPHLQMMKD*" /label="yjcF CDS" gene complement(1139741..1140163) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /label="yjcF gene" CDS complement(1140167..1140682) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12466548, 16511078, 17012785, 18473364, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA ligase or phosphoesterase" /protein_id="NP_389067.1" /db_xref="EnsemblGenomes-Gn:BSU11850" /db_xref="EnsemblGenomes-Tr:CAB13042" /db_xref="GOA:O31629" /db_xref="InterPro:IPR009097" /db_xref="InterPro:IPR022932" /db_xref="PDB:2D4G" /db_xref="SubtiList:BG13160" /db_xref="UniProtKB/Swiss-Prot:O31629" /translation="MKYGIVLFPSKKLQDLANSYRKRYDPSYSLIPPHLTLRASFECA EEKADQLVSHLRNIAKESHPLVLKMTKYSSFAPVNNVIYIKAEPTEELKTLNEKLYTG VLAGEQEYNFVPHVTVGQNLSDDEHSDVLGQLKMQEVSHEEIVDRFHLLYQLENGSWT VYETFLLGRGE*" /label="yjcG CDS" gene complement(1140167..1140682) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /label="yjcG gene" CDS complement(1140719..1141441) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative stress-related hydrolase" /protein_id="NP_389068.1" /db_xref="EnsemblGenomes-Gn:BSU11860" /db_xref="EnsemblGenomes-Tr:CAB13043" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13161" /db_xref="UniProtKB/Swiss-Prot:O31630" /translation="MAPKNGTVQEKKFFSKELNEEMTLLVYLPSNYSPLYKYHVIIAQ DGHDYFRLGRIGRQVEELLSKREIDRSIIIGVPYKDVKERRNTYHPEGSKFSAYKRFI AHELVPFADDEYPTYQIGYGRTLIGDSLGATVSLMTALDYPNMFGNIIMQSPYVDKHV LEAVKQSDDIKHLSIYHQIGTKETDVHTTDGNILDFTEPNRELKQLLEKKLSDYDFEP FDGDHKWTYWQPLITPALKKML*" /label="yjcH CDS" gene complement(1140719..1141441) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /label="yjcH gene" misc_feature complement(1141480..1141499) /Source="Nicolas_upshift_promotors" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1141501) /Source="Nicolas_upshifts" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1141550..1141557 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1141572..1141591 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1141576 /Source="Nicolas_upshifts" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1141609..1141729 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswA RNA" gene 1141609..1141729 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /label="mswA gene" downshifts 1141734 /Source="Nicolas_upshifts" /id="D651" /incds=0 /nref=8 /ntot=59 /MaxReadThrough="7.71668" /MaxDrop="5.0477" /score="31.1477774" /energy="-15.2" /TU="U964" /idTUdmin="U962" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" CDS 1141797..1142918 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /EC_number="2.5.1.49" /EC_number="2.5.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-synthase and O-acetylhomoserine thiolyase" /protein_id="NP_389069.1" /db_xref="EnsemblGenomes-Gn:BSU11870" /db_xref="EnsemblGenomes-Tr:CAB13044" /db_xref="GOA:O31631" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13162" /db_xref="UniProtKB/Swiss-Prot:O31631" /translation="MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGF DYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGG TYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIAR ITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLG EEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLY PGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPATQTHMDIPEEIRIA NGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE*" /label="metI CDS" gene 1141797..1142918 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /label="metI gene" CDS 1142911..1144083 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /EC_number="4.4.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 11948165, 15760717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 11948165, 15760717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-lyase" /protein_id="NP_389070.1" /db_xref="EnsemblGenomes-Gn:BSU11880" /db_xref="EnsemblGenomes-Tr:CAB13045" /db_xref="GOA:O31632" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13163" /db_xref="UniProtKB/Swiss-Prot:O31632" /translation="MSKHNWTLETQLVHNPFKTDGGTGAVSVPIQHASTFHQSSFEEF GAYDYSRSGTPTRTALEETIAALEGGTRGFAFSSGMAAISTAFLLLSQGDHVLVTEDV YGGTFRMVTEVLTRFGIEHTFVDMTDRNEVARSIKPNTKVIYMETPSNPTLGITDIKA VVQLAKENGCLTFLDNTFMTPALQRPLDLGVDIVLHSATKFLSGHSDVLSGLAAVKDE ELGKQLYKLQNAFGAVLGVQDCWLVLRGLKTLQVRLEKASQTAQRLAEFFQKHPAVKR VYYPGLADHPGAETHKSQSTGAGAVLSFELESKEAVKKLVENVSLPVFAVSLGAVESI LSYPATMSHAAMPKEEREKRGITDGLLRLSVGVEHADDLEHDFEQALKEIAPVSVR*" /label="metC CDS" gene 1142911..1144083 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /label="metC gene" downshifts 1144066 /Source="Nicolas_upshifts" /id="D652" /incds=0 /nref=108 /ntot=205 /MaxReadThrough="4.73188" /MaxDrop="5.54268" /score="4.00424187" /energy="-9.2" /TU="U964" /idTUdmin="U964" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" misc_feature 1144100..1144118 /Source="Nicolas_upshift_promotors" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1144110 /Source="Nicolas_upshifts" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="upshifts" S_feature 1144111..1145640 /Source="Nicolas_S_feature" /locus_tag="new_1260806_1262335" /HighExp="MG 5, MG t5, MG 10, BMM, GM 25, MG 15, Glu, GM 15, GM 45, GM 10" /AntisenseName="yjcK" /AntisenseCor="0.123731990206979" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.671, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S428" CDS complement(1144116..1144661) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /EC_number="2.3.1.267" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2828880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal-protein-alanine N-acetyltransferase" /protein_id="NP_389071.1" /db_xref="EnsemblGenomes-Gn:BSU11890" /db_xref="EnsemblGenomes-Tr:CAB13046" /db_xref="GOA:O31633" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13164" /db_xref="UniProtKB/Swiss-Prot:O31633" /translation="MLKGKTIYVRPLEVTDAEENLGLQSENRDFFEQFSMIRADDYYT VEGQRKRITEYQERLEKDEEYHFGIFTASDDRLIGTVSLFQIIRGALQTAFIGYFLDK AHNGKGIMTEAVRLVVDYAFHELKLHRIEAGVMPRNLGSMRVLEKAGFHKEGIARKNV KINGVWEDHQVLAILNPDDEQ*" /label="yjcK CDS" gene complement(1144116..1144661) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /label="yjcK gene" downshifts complement(1144137) /Source="Nicolas_upshifts" /id="D653" /incds=0 /nref=14 /ntot=127 /MaxReadThrough="0.4032" /MaxDrop="4.23858" /score="-7.12102596" /energy="-7.3" /TU="NA" /idTUdmin="U966" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1144731..1145921) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein; possibly aquaporin-related" /protein_id="NP_389072.1" /db_xref="EnsemblGenomes-Gn:BSU11900" /db_xref="EnsemblGenomes-Tr:CAB13047" /db_xref="GOA:O31634" /db_xref="InterPro:IPR008537" /db_xref="SubtiList:BG13165" /db_xref="UniProtKB/Swiss-Prot:O31634" /translation="MHSLISSDDVWVLWGFIAVWAAVSIGLEQRFKWASAVSGAIIAL AGAMVFTNVGVLPVESPVYDTVWSYVVPLAIPLLLFQINVRQIFKESRRLLFIFLISS VGTVLGSILAFFLLKQHIPYLDKIGGMISASYIGGGVNFAAMAAKFETPGEYVSATVV ADNFMMALLFFILISIPALKWFQRHYAMPFEEKVKADGNSGNSAESYWKRKDISLKDI AFNAGAAFALVAVSMKVSGYFKSIFSHPLLTGTLGDQYLVLTSLTVLIIFLFPRFFER LNGSQELGTFLIYLFFVVIGIPADLRLIVTNAPLILLFVFIIAISNLAVSLAAGKLFR VRLEEILLAVNATVGGPTTAAAMAIAKGWRELVAPIMLVGTLGYLIGNYVGTFMGNWF SSFL*" /label="yjcL CDS" gene complement(1144731..1145921) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /label="yjcL gene" promotor_-10 complement(1145947..1145966) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1145951) /Source="Nicolas_upshifts" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1145981..1145988) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1146015..1146022 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1146026 /Source="Nicolas_upshifts" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1146036..1146055 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-10" tRNA 1146094..1146166 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="valine tRNA (GAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val2 tRNA" gene 1146094..1146166 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /label="trnSL-Val2 gene" promotor_-10 complement(1146108..1146125) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1146122) /Source="Nicolas_upshifts" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1146146..1146152) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1146156 /Source="Nicolas_upshifts" /id="D654" /incds=0 /nref=17 /ntot=80 /MaxReadThrough="4.64061" /MaxDrop="5.10012" /score="20.8247903" /energy="-9.1" /TU="U967" /idTUdmin="U965" /TUdmin=550 /isTUend="FALSE" /label="downshifts" S_feature complement(1146181..1146916) /Source="Nicolas_S_feature" /locus_tag="new_1262876_1263611_c" /HighExp="M9-stat, Lbstat, M0t90, Pyr, T0.30H, M40t90, C30, S1, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S429" S_feature 1146201..1147849 /Source="Nicolas_S_feature" /locus_tag="new_1262896_1264544" /HighExp="Cold, C30, G135, G180, G150, Oxctl, Fru, HPh, Glu, UNK1" /AntisenseName="yjcM" /AntisenseCor="0.46809452811910301" /AntisenseRegPval="-15.3" /CDS_PredictionProba="0.27514300000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S430" downshifts complement(1146210) /Source="Nicolas_upshifts" /id="D655" /incds=0 /nref=29 /ntot=192 /MaxReadThrough="1.23936" /MaxDrop="3.57085" /score="-4.98447688" /energy="-7.9" /TU="NA" /idTUdmin="U970" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1146918..1147006) /Source="Nicolas_S_feature" /locus_tag="new_1263613_1263701_c" /HighExp="aero, HPh, M0t45, SMM, dia0, GM 150, Mal, M/G, Mt0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S431" downshifts complement(1146961) /Source="Nicolas_upshifts" /id="D656" /incds=0 /nref=34 /ntot=148 /MaxReadThrough="4.13737" /MaxDrop="4.5557" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-751" /isTUend="FALSE" /label="downshifts" CDS complement(1147007..1148236) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20011599" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389073.1" /db_xref="EnsemblGenomes-Gn:BSU11910" /db_xref="EnsemblGenomes-Tr:CAB13048" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG13166" /db_xref="UniProtKB/Swiss-Prot:O31635" /translation="MKKELLASLVLCLSLSPLVSTNEVFAATTNKETKENVSITNEIG YEKVKDMLEQQKYDFEHNTPLAHPKESKLTDSDEGVLLYSALSKVDKQKFHEFTYDID DVKTSEKNNKLIVEAYITRNFVFGVEKVTTSLGDNIKLEIPKTTSNKQSSQSTNTSNL SFSQVKNSSNQLNVIPLSNSSKQLNVTQLNNSSSTLQYENDEEYSSDVKLDEFLKKYK QEVKNDDKEEVKSEDKPVSMNFNAANSNQLTVTATSVKGYSGYAAMKYAEKYALKPNK NYKYYKDKDCTNFVSQALRAGRMPYFKEWKPYTDAWVNAGAFRSYILKAGGIKMKTVS DTYSNVKLGDVYHYDYHNKIGLRYADGWMDHTAIVTSRANMKLYVSYHSTNRLNVPRE YVTSKEGGKRYVSSIRN*" /label="yjcM CDS" gene complement(1147007..1148236) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /label="yjcM gene" downshifts complement(1147129) /Source="Nicolas_upshifts" /id="D657" /incds=1 /nref=4 /ntot=143 /MaxReadThrough="5.58558" /MaxDrop="3.45178" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-919" /isTUend="FALSE" /label="downshifts" downshifts 1147806 /Source="Nicolas_upshifts" /id="D658" /incds=1 /nref=1 /ntot=48 /MaxReadThrough="3.19343" /MaxDrop="1.98614" /score="26.2462772" /energy="-24.7" /TU="NA" /idTUdmin="U967" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1148237..1148322) /Source="Nicolas_S_feature" /locus_tag="new_1264932_1265017_c" /HighExp="aero, SMM, T-3.40H, MG 150, Lbexp, SMMPr, GM 90, C90, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S432" promotor_-35 1148277..1148284 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1148299..1148318 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1148308..1148327) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1148312 /Source="Nicolas_upshifts" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1148326) /Source="Nicolas_upshifts" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1148340..1148346) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1148362..1148682 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389074.1" /db_xref="EnsemblGenomes-Gn:BSU11920" /db_xref="EnsemblGenomes-Tr:CAB13049" /db_xref="SubtiList:BG13167" /db_xref="UniProtKB/Swiss-Prot:O31636" /translation="MKKKTKIILSLLAALIVILIVLPVLSPVVFTASSEKGAIRHEIY KRGYPYQSYFAVLQKREGDNESGNLYYVNWLDWKDETGQTPHLCYSKKSSDGEYEVSC GTGP*" /label="yjcN CDS" gene 1148362..1148682 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /label="yjcN gene" downshifts 1148692 /Source="Nicolas_upshifts" /id="D659" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="3.73892" /MaxDrop="4.41989" /score="26.2462772" /energy="-24.7" /TU="U969" /idTUdmin="U967" /TUdmin=886 /isTUend="FALSE" /label="downshifts" S_feature 1148737..1148834 /Source="Nicolas_S_feature" /locus_tag="new_1265432_1265529" /HighExp="LoTm, B60, Cold, B36, T3.30H, T3.0H, T4.0H, T2.0H, Sw, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S433" CDS 1148835..1148966 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097707.1" /db_xref="EnsemblGenomes-Gn:BSU11928" /db_xref="EnsemblGenomes-Tr:CAX52597" /db_xref="UniProtKB/Swiss-Prot:C0H3Z0" /translation="MKQSKKKPSQKQHERLDRFWQQMMNTNMQTLRRGKGGAYKRRK* " /label="yjzF CDS" gene 1148835..1148966 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /label="yjzF gene" CDS 1148982..1149155 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097708.1" /db_xref="EnsemblGenomes-Gn:BSU11929" /db_xref="EnsemblGenomes-Tr:CAX52598" /db_xref="UniProtKB/Swiss-Prot:C0H3Z1" /translation="MMKNGFAYKNGKLVNIFCGKEELYNELKAFLVKTFSINVKEVSR PSIYRRTKSKQLE*" /label="yjzG CDS" gene 1148982..1149155 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /label="yjzG gene" CDS 1149192..1149653 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative DNA binding protein; phage island" /protein_id="NP_389075.1" /db_xref="EnsemblGenomes-Gn:BSU11930" /db_xref="EnsemblGenomes-Tr:CAB13050" /db_xref="GOA:O31637" /db_xref="InterPro:IPR013324" /db_xref="SubtiList:BG13168" /db_xref="UniProtKB/Swiss-Prot:O31637" /translation="MTDQMIAWEIEEWIRDYKFMLREIKRLNRVLNKVDFISTKLTAT YGEEAGMPRGSAGVSQAELRQMDRRERRLHKYESIVHYLDNAMEHIEEEKHRIVYDCM MEGMSYTAIANHLDCSRDTIRKIKTAIIGNIVNKVKEANFLQYLNSFKSAV*" /label="yjcO CDS" gene 1149192..1149653 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /label="yjcO gene" promotor_-35 1149624..1149631 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-35" promotor_-10 1149646..1149665 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-10" S_feature 1149654..1149894 /Source="Nicolas_S_feature" /locus_tag="new_1266349_1266589" /HighExp="LoTm, B60, Cold, B36, Diami, S8, dia15, C30, dia5, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12525800000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S434" upshifts 1149654 /Source="Nicolas_upshifts" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="upshifts" promotor_-35 1149867..1149874 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1149888..1149906 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1149896 /Source="Nicolas_upshifts" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1149919..1150422 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein: phage island" /protein_id="NP_389076.1" /db_xref="EnsemblGenomes-Gn:BSU11940" /db_xref="EnsemblGenomes-Tr:CAB13051" /db_xref="GOA:O31638" /db_xref="SubtiList:BG13169" /db_xref="UniProtKB/Swiss-Prot:O31638" /translation="MKKQKNNKKKNIEKRNIEKRNIEEKNNEDLEELENAIYTYHKKE LLAFFLEKTRIGHDKEEYKRFQSLLYKLDIECLEFAISRFSHIDIIHDHSKYVPAFIP LFAAYLTMFFNFYEKHWGALSFAAGTIAAIVWIIAVERKHRNQAISIMKIFEQVKERK VKDRSKD*" /label="yjcP CDS" gene 1149919..1150422 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /label="yjcP gene" CDS 1150434..1150718 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389077.1" /db_xref="EnsemblGenomes-Gn:BSU11950" /db_xref="EnsemblGenomes-Tr:CAB13052" /db_xref="InterPro:IPR018597" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HGC" /db_xref="SubtiList:BG13170" /db_xref="UniProtKB/Swiss-Prot:O31639" /translation="MNKDKLRYAILKEIFEGNTPLSENDIGVTEDQFDDAVNFLKREG YIIGVHYSDDRPHLYKLGPELTEKGENYLKENGTWSKAYKTIKEIKDWIK*" /label="yjcQ CDS" gene 1150434..1150718 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /label="yjcQ gene" downshifts 1150688 /Source="Nicolas_upshifts" /id="D660" /incds=0 /nref=215 /ntot=271 /MaxReadThrough="1.63272" /MaxDrop="7.26386" /score="22.0381158" /energy="-7.2" /TU="NA" /idTUdmin="U969" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1150720) /Source="Nicolas_upshifts" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1150731..1150734) /Source="Nicolas_upshift_promotors" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1150879..1151406 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7489895, 7704261; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage-related nucleic acid binding terminase small subunit; phage island" /protein_id="NP_389078.1" /db_xref="EnsemblGenomes-Gn:BSU11960" /db_xref="EnsemblGenomes-Tr:CAB13053" /db_xref="GOA:O31640" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010332" /db_xref="SubtiList:BG13171" /db_xref="UniProtKB/Swiss-Prot:O31640" /translation="MAEKHIQAYKDYVKGMKYKDLAEKYGVSVNTIKSWKQRHGWERK KGAPIEKSVHTKKGGQPGNKNALGNNGGAPQKNQNAVTHGFFSKFLPEETLEIMEEIQ ERSPADMIWDQIQIQYAAILRAQKIMFVSDKEEMIKELKKKRSLISEVSEIEDGLVIS FSTWFRYRLYSETNT*" /label="yjcR CDS" gene 1150879..1151406 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /label="yjcR gene" promotor_-35 1151553..1151558 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1151571..1151590 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1151574 /Source="Nicolas_upshifts" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="upshifts" CDS 1151580..1151897 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389079.1" /db_xref="EnsemblGenomes-Gn:BSU11970" /db_xref="EnsemblGenomes-Tr:CAB13054" /db_xref="GOA:O31641" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:1Q8B" /db_xref="SubtiList:BG13172" /db_xref="UniProtKB/Swiss-Prot:O31641" /translation="MKSHKMMGGGISMHYITACLKIISDKDLNEIMKEFKKLEEETNK EEGCITFHAYPLEPSERKIMLWEIWENEEAVKIHFTKKHTIDVQKQELTEVEWLMKSN VND*" /label="yjcS CDS" gene 1151580..1151897 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /label="yjcS gene" S_feature 1151898..1152133 /Source="Nicolas_S_feature" /locus_tag="new_1268593_1268828" /HighExp="dia5, H2O2, dia15, dia0, Lbexp, Lbtran, C90, Oxctl, S1, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S435" CDS 1152134..1152889 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2243795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-carrier protein oxidoreductase; phage island" /protein_id="NP_389080.1" /db_xref="EnsemblGenomes-Gn:BSU11980" /db_xref="EnsemblGenomes-Tr:CAB13055" /db_xref="GOA:O31642" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13173" /db_xref="UniProtKB/Swiss-Prot:O31642" /translation="MSHSQEKIALITGASSQGDIGTAICRKLASQGIHIFFTHWNSDT AWIEEFQQEILRMGVRCEAMKIDLSDAHAAFTIHEKISDKLGYPSILINNAAHSASDN YVSLDAKSLDEHYAVNMRSNFLLCVEFARRFKKSNLISGRIINMTSGQDLGPLPGELA YAATKGAISAFTRSLSQELAPLGITVNAVNPGPTDSTWMTDEIRNFLSPKFPMGRIGT PDDAARMIAFLASDEAEWITGQIIHSEGGFIRG*" /label="yjdA CDS" gene 1152134..1152889 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /label="yjdA gene" S_feature 1152890..1152977 /Source="Nicolas_S_feature" /locus_tag="new_1269585_1269672" /HighExp="C90, S1, dia0, dia5, Mt0, Lbexp, Gly, H2O2, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S436" downshifts 1152934 /Source="Nicolas_upshifts" /id="D661" /incds=0 /nref=89 /ntot=238 /MaxReadThrough="2.66489" /MaxDrop="5.39812" /score="-0.84766737" /energy="-14.2" /TU="NA" /idTUdmin="U974" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(1152977..1153037) /Source="Nicolas_S_feature" /locus_tag="new_1269672_1269732_c" /HighExp="Lbstat, BI, BT, nit, S2, ferm, B60, B36, M0t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S437" downshifts complement(1153008) /Source="Nicolas_upshifts" /id="D662" /incds=0 /nref=80 /ntot=134 /MaxReadThrough="1.9707" /MaxDrop="7.43843" /score="-5.56180712" /energy="-14.2" /TU="NA" /idTUdmin="U975" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1153038..1153385) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported protein; phage island" /protein_id="NP_389081.1" /db_xref="EnsemblGenomes-Gn:BSU11990" /db_xref="EnsemblGenomes-Tr:CAB13056" /db_xref="InterPro:IPR003343" /db_xref="InterPro:IPR008964" /db_xref="SubtiList:BG13174" /db_xref="UniProtKB/Swiss-Prot:O31643" /translation="MNFKKTVVSALSISALALSVSGVASAHEINSTPTEVKNISISPT HVIKIQDYNLPLKVGETYSVKNNSATRYWTDNQKVAEVDQNGLVTAKSKGKATITLFK GTAVFGKVYVTVY*" /label="yjdB CDS" gene complement(1153038..1153385) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /label="yjdB gene" promotor_-10 complement(1153417..1153435) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1153430) /Source="Nicolas_upshifts" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1153432..1153888) /Source="Nicolas_S_feature" /locus_tag="new_1270127_1270583_c" /HighExp="T1.30H, T2.0H, T2.30H, T3.0H, M9-stat, T1.0H, Lbstat, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S438" promotor_-35 complement(1153446..1153454) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1153848..1153866 /Source="Nicolas_upshift_promotors" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1153860 /Source="Nicolas_upshifts" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="upshifts" promotor_-10 complement(1153866..1153885) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1153888) /Source="Nicolas_upshifts" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1153899..1153906) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1153936..1155882 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10438772, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438772, 10960106, 23551403; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional DNA-binding activator" /protein_id="NP_389082.2" /db_xref="EnsemblGenomes-Gn:BSU12000" /db_xref="EnsemblGenomes-Tr:CAB13057" /db_xref="GOA:O31644" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG13175" /db_xref="UniProtKB/Swiss-Prot:O31644" /translation="MEYINTRQKEILYLLLSEPDDYLVVQDFADRVQCSEKTIRNDLK VIEDYLNEHSHAQLIRKPGLGVYLHIEEQERTWLSQQLHTEHFSSRQRSDKERMLHIA YDLLMNPKPVSAKDIAARHFVNRSSIKKDLYAVEEWLKRFDLTLVSRQRLGLKVEGNE RNKRKALARISDLIHNTAFTSQFIKSKFLHYEVDFVTKEIKSLQKKHSLYFTDETFES LLLHTLLMVRRIKMKQPISLSPKEMAAVKKKKEYQWTFACLQRLEPVFAIRFPEEEAV YLTLHILGGKVRYPLQTEENLENAVLPKVVGHLINRVSELKMMDFHKDQDLINGLNIH LNTVLQRLSYDLSVANPMLNDIKKMYPYLFHLIIDVLEDINQTFDLHIPEEEAAYLTL HFQAAIERMQGSSETHKKAVIVCHMGIGMSQLLRTKIERKYHQIAVMACIAKADLKDY IKKHEDIDLVISTIALENITVPHIVVSPLLEPGEEKKLSAFIRQLGESHRQKQKTFQM LNNTTPFLVFLQQEAEHRYKLIEQLATALFEKGYVDKDYAVHAVMREKMSATNIGSGI AIPHANAKFIKQSAIAIATLKEPLEWGNEKVSLVFMLAVKHEDQTMTKQLFSELSYLS EQPAFVQKLTKETNVMTFLSHLDY*" /label="manR CDS" gene 1153936..1155882 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /label="manR gene" downshifts 1155858 /Source="Nicolas_upshifts" /id="D663" /incds=0 /nref=3 /ntot=35 /MaxReadThrough="4.64475" /MaxDrop="3.79938" /score="28.4199725" /energy="-9.1" /TU="U976" /idTUdmin="U976" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" SCAR 1155912..1155913 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs02" S_feature <1155913..1156011 /Source="Nicolas_S_feature" /locus_tag="new_1275640_1275738" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, H2O2, dia5, Fru, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15168699999999999" /TUshortSig="SigA" /TUshortPSig="0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S439" promotor_-35 1155986..1155992 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1156007..1156026 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1156013..1156081 /Source="Nicolas_S_feature" /locus_tag="new_1275740_1275808" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, dia5, Fru, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S440" upshifts 1156013 /Source="Nicolas_upshifts" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="upshifts" CDS 1156082..1156564 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20139185" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389085.1" /db_xref="EnsemblGenomes-Gn:BSU12030" /db_xref="EnsemblGenomes-Tr:CAB13060" /db_xref="InterPro:IPR016787" /db_xref="SubtiList:BG13178" /db_xref="UniProtKB/Swiss-Prot:O31647" /translation="MSVTFPSSGCPSFFNIFYEEGIVMKLTIYYDGQFWVGVVEVVDN GKLRAFRHLFGKEPRDSEVLEFVHNQLLNMMAQAEQEGVRLQGRRQKKINPKRLQRQV SKELKNAGVTSKAQEAIKLELEARKQKKKQIMKEQREHVKEQRYMLKKQKAKKKHRGK *" /label="yjdF CDS" gene 1156082..1156564 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /label="yjdF gene" downshifts 1156544 /Source="Nicolas_upshifts" /id="D664" /incds=0 /nref=220 /ntot=267 /MaxReadThrough="5.32805" /MaxDrop="7.35641" /score="7.68574519" /energy="-10.2" /TU="U978" /idTUdmin="U980" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1156610..1157116) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389086.1" /db_xref="EnsemblGenomes-Gn:BSU12040" /db_xref="EnsemblGenomes-Tr:CAB13061" /db_xref="GOA:O31648" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13179" /db_xref="UniProtKB/Swiss-Prot:O31648" /translation="MVLLETNRLRLQTIDIPLLDAASKQDHQAIKELGYETNGEWPNS DFFEAIPYFREILVKNNGTKGFDSWIIVKKDNYEIVGGTGFLGDPDENGMIEIGFATN KSHRRKGYCVEAAQKLINWALSRETVSRITARCEHDNLGSQKTLEKLGFILNHKSAEY KHWIYVTK*" /label="yjdG CDS" gene complement(1156610..1157116) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /label="yjdG gene" downshifts complement(1156634) /Source="Nicolas_upshifts" /id="D665" /incds=0 /nref=13 /ntot=154 /MaxReadThrough="2.51872" /MaxDrop="4.09551" /score="15.8830125" /energy="-9.9" /TU="NA" /idTUdmin="U984" /TUdmin=7 /isTUend="TRUE" /label="downshifts" misc_feature complement(1157141..1157160) /Source="Nicolas_upshift_promotors" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1157147) /Source="Nicolas_upshifts" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1157149..1157334) /Source="Nicolas_S_feature" /locus_tag="new_1276876_1277061_c" /HighExp="S5, S4, S7, S6, S8, B36, LoTm, S3, B60, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.289238" /TUshortSig="SigEF, SigWXY" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S441" CDS complement(1157335..1157730) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389087.2" /db_xref="EnsemblGenomes-Gn:BSU12050" /db_xref="EnsemblGenomes-Tr:CAB13062" /db_xref="SubtiList:BG13180" /db_xref="UniProtKB/Swiss-Prot:O31649" /translation="MYHYFYGPALIPYFSHTHNPQRSPDFSERQRRREITLTVDGFVP PSSTEDLGDGFYSYAWTNQQVINPGEYLVCHLEGRDINVINGGFTPRDTAPLYAVASF PRRRNQWVIIIHNPVQTQRAISLYLIAKR*" /label="yjdH CDS" gene complement(1157335..1157730) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /label="yjdH gene" promotor_-10 complement(1157753..1157771) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1157766) /Source="Nicolas_upshifts" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1157768..1158468) /Source="Nicolas_S_feature" /locus_tag="new_1277495_1278195_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, S0, T2.0H, Salt, T2.30H, T-1.10H" /AntisenseName="yjdI" /AntisenseCor="-0.383915151906285" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S442" promotor_-35 complement(1157786..1157791) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1157874..1157881 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1157895..1157914 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1157906 /Source="Nicolas_upshifts" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="upshifts" CDS 1157959..1158438 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22128149; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cys-tRNApro deacetylase; tRNA editing" /protein_id="NP_389088.1" /db_xref="EnsemblGenomes-Gn:BSU12060" /db_xref="EnsemblGenomes-Tr:CAB13063" /db_xref="GOA:O31650" /db_xref="InterPro:IPR004369" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG13181" /db_xref="UniProtKB/Swiss-Prot:O31650" /translation="MAKKMAKTNAVRLIEQQNISYEVLGYKTDGQPVDGISVAEKIGY SLKYVYKTLVAAAGTNHYYVFVVPVAEELDVKKAAKVTGEKKIEMIAMKELLAVTGYL RGGCSPIGMKKLFPTYIDASAETLDFIIVSAGKIGMQLKLAPQDLARSCDAAFAEIV* " /label="trnE CDS" gene 1157959..1158438 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /label="trnE gene" downshifts 1158437 /Source="Nicolas_upshifts" /id="D666" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="2.68858" /MaxDrop="3.19616" /score="-5.52314972" /energy="-12.5" /TU="NA" /idTUdmin="U978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1158478..1158672) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097709.1" /db_xref="EnsemblGenomes-Gn:BSU12069" /db_xref="EnsemblGenomes-Tr:CAX52599" /db_xref="InterPro:IPR025234" /db_xref="UniProtKB/Swiss-Prot:C0H3Z2" /translation="MKEYEFVRVELSTMRRRPKEDYQQIIHDYAKRGWRFVQIFAPSI DGYGAAAYFEIIFERDAEKA*" /label="yjzH CDS" gene complement(1158478..1158672) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /label="yjzH gene" downshifts complement(1158513) /Source="Nicolas_upshifts" /id="D667" /incds=0 /nref=6 /ntot=144 /MaxReadThrough="7.83072" /MaxDrop="2.95935" /score="-6.07514027" /energy="-7" /TU="U984" /idTUdmin="U987" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1158686..1158701) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1158702) /Source="Nicolas_upshifts" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1158713..1158722) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1158838..1159167) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389089.1" /db_xref="EnsemblGenomes-Gn:BSU12070" /db_xref="EnsemblGenomes-Tr:CAB13064" /db_xref="GOA:O31651" /db_xref="InterPro:IPR016508" /db_xref="InterPro:IPR025440" /db_xref="SubtiList:BG13182" /db_xref="UniProtKB/Swiss-Prot:O31651" /translation="MKGIFLVVQLGFSIMVFLFLAAVNWYQGSELVSDRFDWNYTAKL SKLLNGIDAVSSPKQISQLDFFIYSAKHYPVMSALMIISFLYVLAALFLLIYSVKCNK QEIHLDC*" /label="yjdJ CDS" gene complement(1158838..1159167) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /label="yjdJ gene" promotor_-10 complement(1159204..1159223) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1159217) /Source="Nicolas_upshifts" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1159219..1159786) /Source="Nicolas_S_feature" /locus_tag="new_1278946_1279513_c" /HighExp="S8, S6, nit, S7, ferm, S2, S5, M9-tran, M/G, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S443" promotor_-35 complement(1159238..1159243) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1159271..1159275 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1159291..1159310 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1159295..1159796 /Source="Nicolas_S_feature" /locus_tag="new_1279022_1279523" /HighExp="LBGstat, C30, HPh, Oxctl, dia15, Paraq, T0.30H, C90, LBGtran, LPh" /AntisenseName="ctaO" /AntisenseCor="-0.43946575370083102" /AntisenseRegPval="-13.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S444" upshifts 1159295 /Source="Nicolas_upshifts" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1159787..1160776) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10675592, 15491161, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10675592, 15491161, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor protoheme IX farnesyltransferase 1 (heme Osynthase)" /protein_id="NP_389090.2" /db_xref="EnsemblGenomes-Gn:BSU12080" /db_xref="EnsemblGenomes-Tr:CAB13065" /db_xref="GOA:O31652" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG13183" /db_xref="UniProtKB/Swiss-Prot:O31652" /translation="MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGI IISNSIAAFGGFWIAFASAEKTLTGLAFLMTMVTAMLGTAFVMASGTVYNNYFDRHMD AKMARTRSRASVTGKMPPAMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIY TVWVKRTSVWSTFVGSFPGAAPPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGI RRKEEYRAAGVPLLPVVKGNHVTKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAA LVLGGIWIKKSIKGFKTDDDVKWAKDMFVYSLIYFCLLFFIMMIDSFMMFLIR*" /label="ctaO CDS" gene complement(1159787..1160776) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /label="ctaO gene" promotor_-10 complement(1160777..1160796) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-10" upshifts complement(1160780) /Source="Nicolas_upshifts" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="upshifts" promotor_-35 complement(1160810..1160815) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-35" CDS complement(1160899..1161147) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1391045, 1917883, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1391045, 1917883, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner coat)" /protein_id="NP_389091.2" /db_xref="EnsemblGenomes-Gn:BSU12090" /db_xref="EnsemblGenomes-Tr:CAB13066" /db_xref="GOA:P11863" /db_xref="SubtiList:BG10495" /db_xref="UniProtKB/Swiss-Prot:P11863" /translation="MDYPLNEQSFEQITPYDERQPYYYPRPRPPFYPPYYYPRPYYPF YPFYPRPPYYYPRPRPPYYPWYGYGGGYGGGYGGGYGY*" /label="cotT CDS" gene complement(1160899..1161147) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /label="cotT gene" downshifts complement(1160909) /Source="Nicolas_upshifts" /id="D668" /incds=0 /nref=37 /ntot=82 /MaxReadThrough="5.73194" /MaxDrop="6.23577" /score="25.0951218" /energy="-8.4" /TU="U989" /idTUdmin="U990" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1161143..1161147 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1161156..1161170 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1161165 /Source="Nicolas_upshifts" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1161172..1161191) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1161181) /Source="Nicolas_upshifts" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1161205..1161214) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1161262..1161269 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1161276..1161295) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1161283..1161302 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1161285) /Source="Nicolas_upshifts" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="upshifts" upshifts 1161296 /Source="Nicolas_upshifts" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1161297..1161400 /Source="Nicolas_S_feature" /locus_tag="new_1281024_1281127" /HighExp="Heat, T0.30H, T1.0H, ferm, Diami, dia5, T1.30H, M9-stat, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S445" promotor_-35 complement(1161309..1161316) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1161401..1162804 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 17878218, 22277649" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 17878218, 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid deacetylase" /protein_id="NP_389092.1" /db_xref="EnsemblGenomes-Gn:BSU12100" /db_xref="EnsemblGenomes-Tr:CAB13067" /db_xref="GOA:O34798" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR017219" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="SubtiList:BG13184" /db_xref="UniProtKB/Swiss-Prot:O34798" /translation="MLAKRIKWFHVLIAVVCVVGLIGFFHNHSLKKETVMNKVRTDSQ YGNVEIATLVNDGKTFNYAVNYPVFKNEKMDSALKRFAEKEVRQFQKETKDVDQEHTT KRNELNVDYKIVHYAKQTVAIVFNEYKYIGGAHGQTVKKTFNYDFSKQAFLSIDDIFK EDADYLHKLSLIAYHELKKNKDIAADDALLKEGTAPKKENFSRFAIKEDYIELYFDTY QVAAGYLGEQSIAIKKSLLKDILKEQYIDKAKNKNKIKEQKPKHEVISLPKEETVDPN QKVIALTFDDGPNPATTNQILDSLKKYKGHATFFVLGSRVQYYPETLIRMLKEGNEVG NHSWSHPLLTRLSVKEALKQINDTQDIIEKISGYRPTLVRPPYGGINDELRSQMKMDV ALWDVDPEDWKDRNKKTIVDRVMNQAGDGRTILIHDIYRTSADAADEIIKKLTDQGYQ LVTVSQLEEVKKQREAK*" /label="pdaC CDS" gene 1161401..1162804 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /label="pdaC gene" downshifts 1162793 /Source="Nicolas_upshifts" /id="D669" /incds=0 /nref=173 /ntot=238 /MaxReadThrough="1.38483" /MaxDrop="6.60322" /score="39.935002" /energy="-13.8" /TU="NA" /idTUdmin="U991" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1162844..1163317) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389093.1" /db_xref="EnsemblGenomes-Gn:BSU12110" /db_xref="EnsemblGenomes-Tr:CAB13068" /db_xref="InterPro:IPR021224" /db_xref="SubtiList:BG13185" /db_xref="UniProtKB/Swiss-Prot:O34554" /translation="MKRLFMKASLVLFAVVFVFAVKGAPAKAETHAYDGKSPYYNDCA SSGSTKKSSNLVNASNQVIGVVELKFSSTCKTAWAKITMNNTLTSGYEANAEITRNTD GKRYNCDSAGGNGKAVAGQKSCYTPMVYDLDPRTSYAFGKYSGPNLNVWATTGSY*" /label="yjfA CDS" gene complement(1162844..1163317) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /label="yjfA gene" downshifts complement(1162848) /Source="Nicolas_upshifts" /id="D670" /incds=0 /nref=33 /ntot=176 /MaxReadThrough="2.25434" /MaxDrop="5.38548" /score="20.5383759" /energy="-13.8" /TU="NA" /idTUdmin="U992" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1163339..1163357) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1163357) /Source="Nicolas_upshifts" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1163372..1163377) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1163442..1163609) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389094.1" /db_xref="EnsemblGenomes-Gn:BSU12120" /db_xref="EnsemblGenomes-Tr:CAB13069" /db_xref="InterPro:IPR025906" /db_xref="SubtiList:BG13186" /db_xref="UniProtKB/Swiss-Prot:O34438" /translation="MDIPALSVAMHQASLAQNVNIALTKKRLDTAQQNADQTLKMIQH PTLGQTIDVKA*" /label="yjfB CDS" gene complement(1163442..1163609) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /label="yjfB gene" downshifts complement(1163445) /Source="Nicolas_upshifts" /id="D671" /incds=0 /nref=109 /ntot=232 /MaxReadThrough="3.53249" /MaxDrop="4.93218" /score="-9.08395816" /energy="-13.9" /TU="U993" /idTUdmin="U993" /TUdmin="-576" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1163621..1163639) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1163630) /Source="Nicolas_upshifts" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1163652..1163659) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1163736..1164635 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389095.2" /db_xref="EnsemblGenomes-Gn:BSU12130" /db_xref="EnsemblGenomes-Tr:CAB13070" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13187" /db_xref="UniProtKB/Swiss-Prot:O34458" /translation="MNLVMEKTFEQYEKLFSMEEQKREDVFRYTMMRPFEKMWTAIQV PLKAKEPNGYDVIMAAKMLGYLDVRDAESGQKALQILKESHVSETAESALRQCIFFAE REQLRVNAKEIKFGLYIADPNKLQLQKGYCGFGGIPGFIHVWINPNSYNLPRIPSIIA HEFHHNVRFSYIDFHHGSVSVGDYLVIEGLAESFARELFGTERLGPWVTRFDHEDLQY SIDVINEVLDVKGFSEVSRYMFGDPIANDQGFKPAGLSAFAGYAVGYHAVQSFMNQHH ITISEATRLDAKTIISQCGLFST*" /label="yjfC CDS" gene 1163736..1164635 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /label="yjfC gene" CDS complement(1164644..1165042) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_389096.1" /db_xref="EnsemblGenomes-Gn:BSU12140" /db_xref="EnsemblGenomes-Tr:CAB13071" /db_xref="GOA:O35027" /db_xref="InterPro:IPR021257" /db_xref="SubtiList:BG13188" /db_xref="UniProtKB/Swiss-Prot:O35027" /translation="MKRNRWIYAVFTILIIGLGLGSRAFSSVLPDTLNTYLGDSLWAA MIFTGCGFLFRKLKTMITGIISLSFCFVIEFSQLYHAEWIDQIRDTSLGGLVLGYGFL WSDIEAYTIGIAACAAIELLVLGIKKRRCM*" /label="yjgA CDS" gene complement(1164644..1165042) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /label="yjgA gene" downshifts complement(1164674) /Source="Nicolas_upshifts" /id="D672" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.86089" /MaxDrop="2.52307" /score="23.8106216" /energy="-10.1" /TU="U994,U995" /idTUdmin="U995" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1165071..1165090) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1165090) /Source="Nicolas_upshifts" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1165105..1165112) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1165143..1165718) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1580552" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389097.1" /db_xref="EnsemblGenomes-Gn:BSU12150" /db_xref="EnsemblGenomes-Tr:CAB13072" /db_xref="InterPro:IPR025453" /db_xref="PDB:4YGT" /db_xref="SubtiList:BG13189" /db_xref="UniProtKB/Swiss-Prot:O34960" /translation="MKKTMSAITAAAAVTSCFTGFGAASFSAPAKAAAQTNTLSENTN QSAAELVKNLYNTAYKGEMPQQAQGLTINKSTKGDVHAAFGEPERPVGGDNRFDLYHW NMGQPGYGFSYHKDMTISEIRYFGTGVERQLNLGGVTPEVLQKQLGPVNRVLTVPFTD EIDYVYDTGRYELHFVIGTDQTADHVNLKAK*" /label="yjgB CDS" gene complement(1165143..1165718) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /label="yjgB gene" downshifts complement(1165158) /Source="Nicolas_upshifts" /id="D673" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.38565" /MaxDrop="3.9021" /score="23.8106216" /energy="-10.1" /TU="U995" /idTUdmin="U995" /TUdmin="-727" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1165737..1165755) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1165752) /Source="Nicolas_upshifts" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1165769..1165775) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1165793..1165799 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1165814..1165832 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1165815 /Source="Nicolas_upshifts" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="upshifts" CDS 1165864..1168821 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /EC_number="1.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdoenzyme; putative formate dehydrogenase" /protein_id="NP_389098.1" /db_xref="EnsemblGenomes-Gn:BSU12160" /db_xref="EnsemblGenomes-Tr:CAB13073" /db_xref="GOA:O34720" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG13190" /db_xref="UniProtKB/Swiss-Prot:O34720" /translation="MAGKKTITINGVEMEASEEQTVLQLLNNSSIEVPQVCYHPSLGP IETCDTCIVSINGELKRSCSAELKDGDVIDTLSPDVKKAQVIGMDKILYNHELYCTVC DYNNGGCEIHNTVKEMKINHQSIPFDHKPYHKDESHPFYRYDPDQCILCGRCVEACQD VQVTETLTIDWERKRPRVIWDNDVPINESSCVSCGHCSTVCPCNAMMEKGMEGEAGYL TGINNETLRPMIEITKGVETGYGSILAISDMESAMRDERIKKTKTVCTYCGVGCSFDV WTKGRDILKVEPQEEAPANGISTCVKGKFGWDFVNSEERLTKPLIREGDHFREAEWEE ALLLIASKFTELKEAFGPDSLAFITSSKCTNEESYLMQKLARGVIGTNNVDNCSRYCQ SPATAGLFRTVGYGGDSGSITDIAQADLVLIIGSNTSESHPVLSTRIKRAHKLRGQKV IVADIRKHEMAERSDLFVQPRAGSDIVWLNAIAKYLIENGKADERFLRERVNGRDEYV KSLAPYTLEYAEEKTGIDQETLIQMAEMIGQADSVCALWAMGVTQHIGGSDTSTAISN LLLVTGNYGKPGAGSYPLRGHNNVQGASDFGSMPDRLPGYEKVTDEQVRQKYERVWGV PLPKEPGMTNHEMIEKIHSGQLKAMYVKGEEMGLVDSNINHVHAAYEKLDFFVVQDIF LSRTAEFADVVLPASPSLEKEGTFTNTERRIQRLYQVFEPLGESKPDWQIIMEVANKL GAGWLYEHPADIMEEAAKLSPIYAGVTYERLEGYNSLQWPVNADGKDSPLLFTERFPF PDGKAILYPVQWTEPKEFGEEYDIHVNNGRLLEHFHEGNLTYKSKGISEKTPEVFLEI SPELAAERGIQDGTLVRLTSPFGNVKVKCLITDRVKGKEVYLPMNDSGEAAINLLTGS HADKDTDTPAYKETSAKMEILKHDGISPLPKINHRNGNPQPQIGVQVHKKWARKDYIF PGDAVKRGMGHNG*" /label="yjgC CDS" gene 1165864..1168821 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /label="yjgC gene" CDS 1168814..1169374 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389099.1" /db_xref="EnsemblGenomes-Gn:BSU12170" /db_xref="EnsemblGenomes-Tr:CAB13074" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13191" /db_xref="UniProtKB/Swiss-Prot:O34681" /translation="MAKAIKRIQKIEVTEEDQRKRDLREIEDALIDHKEAILETLHML GHMNERGVLPLLRGLFGQGDKVLDILVKKADTEETANTLKNLLLLFGTLGMLDVKQLE PLILKVNAGVASAVEQKNSEEKTGYFDIIRSLKDPEINKSITLLFSFLKGMGQDTKEL ERTTQPPEHQKHHQEPREKRGMNKRD*" /label="yjgD CDS" gene 1168814..1169374 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /label="yjgD gene" downshifts 1169367 /Source="Nicolas_upshifts" /id="D674" /incds=0 /nref=18 /ntot=84 /MaxReadThrough="5.25706" /MaxDrop="6.46184" /score="20.7921843" /energy="-15" /TU="U996" /idTUdmin="U996" /TUdmin="-819" /isTUend="FALSE" /label="downshifts" S_feature 1169412..1169530 /Source="Nicolas_S_feature" /locus_tag="new_1289139_1289257" /HighExp="Etha, Salt, Heat, S8, M9-stat, S7, LPhT, G135, C30, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S446" promotor_-35 1169508..1169511 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1169527..1169546 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1169532 /Source="Nicolas_upshifts" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1169571..1170212 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389100.1" /db_xref="EnsemblGenomes-Gn:BSU12180" /db_xref="EnsemblGenomes-Tr:CAB13075" /db_xref="GOA:O34725" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="PDB:3CFU" /db_xref="SubtiList:BG13192" /db_xref="UniProtKB/Swiss-Prot:O34725" /translation="MKKVLLLLFVLTIGLALSACSQSSDASEKEKPKEKKSQEELEKE LDKELKKGGEPKTKKDDQIHKIGETFKAGHTNFTVNKVDRVQKGEYMNVGGAVNEETK TIKDDEERLIIEVTMENIGEDSISYNFIGFDLRDKNDQSVRPVFSIEEKGRILMGGTL VSGKKVTGVLSYVIPKGEQKHYTLVYNPFLADTNSSNTEERVKDDIDYLVKLD*" /label="yjhA CDS" gene 1169571..1170212 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /label="yjhA gene" downshifts complement(1169580) /Source="Nicolas_upshifts" /id="D675" /incds=0 /nref=7 /ntot=57 /MaxReadThrough="2.5769" /MaxDrop="3.81596" /score="-9.34186213" /energy="-3" /TU="NA" /idTUdmin="U998" /TUdmin=1386 /isTUend="FALSE" /label="downshifts" downshifts 1170185 /Source="Nicolas_upshifts" /id="D676" /incds=0 /nref=24 /ntot=186 /MaxReadThrough="4.29897" /MaxDrop="3.4683" /score="19.6571267" /energy="-17" /TU="U997" /idTUdmin="U996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 1170291..1170917 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /EC_number="3.6.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12483591, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ADP-ribose pyrophosphatase" /protein_id="NP_389101.2" /db_xref="EnsemblGenomes-Gn:BSU12190" /db_xref="EnsemblGenomes-Tr:CAB13076" /db_xref="GOA:C0SPC3" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG13193" /db_xref="UniProtKB/Swiss-Prot:C0SPC3" /translation="MIKVQTKWLERAQRIRAIAQAGLAFSKDVYDRERYEELMKLSAE MMADYSEKDIEVITDLWQGEKGYPTPKADVRGAVFRENQILLVREKHDELWSLPGGFC EIGLSPAENVVKEIKEESGYDTEPSRLLAVLDSHKHSHPPQPYHYYKIFIACSMTDGQ GETGIETNHAAFFPEDRLPPLSPKRNTPSQLSMLFDFLRHPDKKTIFD*" /label="yjhB CDS" gene 1170291..1170917 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /label="yjhB gene" downshifts 1170919 /Source="Nicolas_upshifts" /id="D677" /incds=0 /nref=97 /ntot=202 /MaxReadThrough="0.597580000000001" /MaxDrop="6.62023" /score="12.2319602" /energy="-7" /TU="NA" /idTUdmin="U997" /TUdmin=7 /isTUend="TRUE" /label="downshifts" downshifts complement(1170922) /Source="Nicolas_upshifts" /id="D678" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.18907" /MaxDrop="3.31161" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(1170948..1171226) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 14563871" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389102.1" /db_xref="EnsemblGenomes-Gn:BSU12200" /db_xref="EnsemblGenomes-Tr:CAB13077" /db_xref="SubtiList:BG13194" /db_xref="UniProtKB/Swiss-Prot:O34679" /translation="MAAQTDYKKQVVGILLSLAFVLFVFSFSERHEKPLVEGKKQENW HTVVDKASVKIYGSRLVEENKLKQKLGHKQADSILTLLKLANEKHITL*" /label="yjiA CDS" gene complement(1170948..1171226) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /label="yjiA gene" downshifts complement(1170966) /Source="Nicolas_upshifts" /id="D679" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="1.96302" /MaxDrop="5.98058" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1171255..1171266) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1171268..1171274) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1171274) /Source="Nicolas_upshifts" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1171276..1171692) /Source="Nicolas_S_feature" /locus_tag="new_1291003_1291419_c" /HighExp="S6, S7, S8, S5, BT, C30, Pyr, G/S, C90, B36" /AntisenseName="yjiB" /AntisenseCor="-0.25565388711625397" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S447" upshifts 1171444 /Source="Nicolas_upshifts" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1171445..1171464 /Source="Nicolas_upshift_promotors" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1171462..1171616 /Source="Nicolas_S_feature" /locus_tag="new_1291189_1291343" /HighExp="BC, T5.0H, T4.0H, C90, Sw, T3.30H, Lbstat, Diami, dia5, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.995811" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S448" CDS 1171617..1172807 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25587700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25587700; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP109B1, monooxygenase" /protein_id="NP_389103.1" /db_xref="EnsemblGenomes-Gn:BSU12210" /db_xref="EnsemblGenomes-Tr:CAB13078" /db_xref="GOA:O34374" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4RM4" /db_xref="SubtiList:BG13195" /db_xref="UniProtKB/Swiss-Prot:O34374" /translation="MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF RVKM*" /label="cypE CDS" gene 1171617..1172807 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /label="cypE gene" promotor_-10 complement(1171690..1171709) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1171692) /Source="Nicolas_upshifts" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1171723..1171732) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1172830..1174008 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 24893262, 27444326; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyphenols TDP-rhamnosyltransferase, promiscuous" /protein_id="NP_389104.1" /db_xref="EnsemblGenomes-Gn:BSU12220" /db_xref="EnsemblGenomes-Tr:CAB13079" /db_xref="GOA:O34539" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG13196" /db_xref="UniProtKB/Swiss-Prot:O34539" /translation="MKKYHISMINIPAYGHVNPTLALVEKLCEKGHRVTYATTEEFAP AVQQAGGEALIYHTSLNIDPKQIREMMEKNDAPLSLLKESLSILPQLEELYKDDQPDL IIYDFVALAGKLFAEKLNVPVIKLCSSYAQNESFQLGNEDMLKKIREAEAEFKAYLEQ EKLPAVSFEQLAVPEALNIVFMPKSFQIQHETFDDRFCFVGPSLGERKEKESLLIDKD DRPLMLISLGTAFNAWPEFYKMCIKAFRDSSWQVIMSVGKTIDPESLEDIPANFTIRQ SVPQLEVLEKADLFISHGGMNSTMEAMNAGVPLVVIPQMYEQELTANRVDELGLGVYL PKEEVTVSSLQEAVQAVSSDQELLSRVKNMQKDVKEAGGAERAAAEIEAFMKKSAVPQ *" /label="ppuG CDS" gene 1172830..1174008 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /label="ppuG gene" CDS complement(1174049..1174237) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="YP_003097710.1" /db_xref="EnsemblGenomes-Gn:BSU12229" /db_xref="EnsemblGenomes-Tr:CAX52600" /db_xref="UniProtKB/Swiss-Prot:C0H3Z3" /translation="METKKEEYETKGYDTSIVYEFNEYPDARSGRCDNCDYTLFKSSV KGGKFLRECRRCGMKKNI*" /label="yjzI CDS" gene complement(1174049..1174237) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /label="yjzI gene" downshifts complement(1174065) /Source="Nicolas_upshifts" /id="D680" /incds=0 /nref=94 /ntot=231 /MaxReadThrough="-0.1433" /MaxDrop="5.1712" /score="13.0160925" /energy="-9.5" /TU="NA" /idTUdmin="U1001" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1174263..1174282) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1174266) /Source="Nicolas_upshifts" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1174296..1174302) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1174324..1174331 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1174346..1174365 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1174357 /Source="Nicolas_upshifts" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1174372..1174391) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1174376) /Source="Nicolas_upshifts" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1174406..1174413) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1174411..1175223 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389105.1" /db_xref="EnsemblGenomes-Gn:BSU12230" /db_xref="EnsemblGenomes-Tr:CAB13080" /db_xref="GOA:O34394" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG13197" /db_xref="UniProtKB/Swiss-Prot:O34394" /translation="MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLA EKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEKIGLKDEFLQAIRQAKAACRGYK TLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKG ASVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEV KKVFEERAIAAAVGKVTAEALREEGITRLLAPEIERMGAMIVELAKYYEEKE*" /label="yjjA CDS" gene 1174411..1175223 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /label="yjjA gene" downshifts 1175202 /Source="Nicolas_upshifts" /id="D681" /incds=0 /nref=196 /ntot=254 /MaxReadThrough="3.61369" /MaxDrop="5.73094" /score="10.6328997" /energy="-14.5" /TU="U1002" /idTUdmin="U1002" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1175269..1176021) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_389106.1" /db_xref="EnsemblGenomes-Gn:BSU12240" /db_xref="EnsemblGenomes-Tr:CAB13081" /db_xref="GOA:O34684" /db_xref="InterPro:IPR005226" /db_xref="SubtiList:BG13198" /db_xref="UniProtKB/Swiss-Prot:O34684" /translation="MDYLSLSLTMIFVLIALFLSKSFKAGVEKDMIIATIRAAVQLLI IGYVLSLIFRGDHPVFILLMVLLMLAVAAQNVIKRKKNTIGSFWRVFAALAIVEIVTQ GILLSLHIIPLTARYVIPISGMVIGNSMVLSSLFLNRLNSEVGVRKEEIQLILSLGGT PKQSIQRILTSAMKMSMIPTLESQKTLGLVQLPGMMTGQILAGADPIQAVRFQLLIVF TTMASAALTCVILSVLTYPSLFTVHQQLKQNE*" /label="yjkA CDS" gene complement(1175269..1176021) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /label="yjkA gene" downshifts complement(1175278) /Source="Nicolas_upshifts" /id="D682" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="0.924970000000001" /MaxDrop="3.5673" /score="13.1058081" /energy="-12.8" /TU="NA" /idTUdmin="U1001" /TUdmin="-1210" /isTUend="FALSE" /label="downshifts" CDS complement(1176021..1176773) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389107.1" /db_xref="EnsemblGenomes-Gn:BSU12250" /db_xref="EnsemblGenomes-Tr:CAB13082" /db_xref="GOA:O34756" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13199" /db_xref="UniProtKB/Swiss-Prot:O34756" /translation="MEANDQTQNIPAISFRSVRKSYKQDGQTYDVLQDVTGDIQQGAI VAVLGPSGSGKSTLLSMCNLMRTPDSGEVNIYGKEVREWNVNELRRTAALAFQSAPVL DGTVRDNLSLVQRLHQSQLYSPEKLASLAGLPPELLDRSARDLSGGQRQRLSLARTLS NPSSILLLDEITSALDPVSALEIEELIKRQHQEKKWTVMWVTHNMEQAKRIADTIWFM ADGRLLEIAETDTFFSAPQHEAAKEFLKGGTR*" /label="yjkB CDS" gene complement(1176021..1176773) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /label="yjkB gene" CDS complement(1176893..1177867) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14627822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389108.1" /db_xref="EnsemblGenomes-Gn:BSU12260" /db_xref="EnsemblGenomes-Tr:CAB13083" /db_xref="GOA:O34428" /db_xref="InterPro:IPR032713" /db_xref="SubtiList:BG13200" /db_xref="UniProtKB/Swiss-Prot:O34428" /translation="MKAIVIGILASLFFAVTFILNRAMELSGGSWLWSSSLRFIFMVP FLCLIVIMRGTFTPLLLEMRKKPFYWIKWSFVGFVLFYAPITFAAAYGPGWLIAGTWQ ITIVAGVLLSPLFYVKQDMPGGPQLIRQKIPLVSLGTSVIILIGAALIQLQHAESLSG RMLLFSVLPVVIAAFAYPLGNRRMLEEYGGRLDTFQRVLGMTLASLPFWLILAAYGWW SDGLPTASQTVQSFIVAVSSGIIATVLFFWATDMVRDNPQKLAAVEATQSGEVIFALL GEIVLLSGVFPSLLSFAGLFIIIAGMMLHTFASQPRKPKKKAQSNLTA*" /label="yjlA CDS" gene complement(1176893..1177867) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /label="yjlA gene" downshifts complement(1176928) /Source="Nicolas_upshifts" /id="D683" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="1.84381" /MaxDrop="2.54799" /score="4.80318278" /energy="-14.5" /TU="NA" /idTUdmin="U1004" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1177888..1177907) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1177914) /Source="Nicolas_upshifts" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1177916..1180422) /Source="Nicolas_S_feature" /locus_tag="new_1297643_1300149_c" /HighExp="Lbstat, S2, M0t90, nit, BT, M40t90, ferm, BC, C30, Gly" /AntisenseName="ndh" /AntisenseCor="-0.74506751931257098" /AntisenseRegPval="-48.1" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S449" promotor_-35 complement(1177922..1177929) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1177950..1177956 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1177971..1177989 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1177974 /Source="Nicolas_upshifts" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1177999..1178496 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10704478" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; cupin family" /protein_id="NP_389109.1" /db_xref="EnsemblGenomes-Gn:BSU12270" /db_xref="EnsemblGenomes-Tr:CAB13084" /db_xref="GOA:O34612" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014500" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13201" /db_xref="UniProtKB/Swiss-Prot:O34612" /translation="MERETQTYFFPDDGRIPNHPDFPLVVYQNALKDTGLAERIVTRH GWSNSWSGSVFPYHHYHSNTHEVLIALRREAVIQFGGEKGAAIPFKSGDAVVIPAGVG HKKLSSSPDFTVLGAYPGGVQYDMKTGKPNEREEAVKQIKQAALPANDPITGKREPLL EIWVK*" /label="yjlB CDS" gene 1177999..1178496 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /label="yjlB gene" S_feature 1178497..1178610 /Source="Nicolas_S_feature" /locus_tag="new_1298224_1298337" /HighExp="Etha, M9-stat, B60, Salt, Gly, LPhT, Heat, Sw, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S450" promotor_-35 1178590..1178594 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1178610..1178629 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1178612..1178884 /Source="Nicolas_S_feature" /locus_tag="new_1298339_1298611" /HighExp="LBGtran, dia5, Lbexp, LBGexp, dia0, HPh, aero, LPh, BMM, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S451" upshifts 1178612 /Source="Nicolas_upshifts" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1178885..1179307 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16513748, 17015645, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389110.1" /db_xref="EnsemblGenomes-Gn:BSU12280" /db_xref="EnsemblGenomes-Tr:CAB13085" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13202" /db_xref="UniProtKB/Swiss-Prot:O34633" /translation="MPETIDQTNASVSQSQQDLIDQLLKPEVQESLTVLVDQLPKLTE LVNILTKSYDFAQSVATDEVLKSDTVGAITEILEPVKETAKEVAATAIEAKDRAEASN ETIGLFGLLRMLKDPQAQKLFRFANSYLEVMNERENQK*" /label="yjlC CDS" gene 1178885..1179307 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /label="yjlC gene" CDS 1179347..1180525 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /EC_number="1.6.99.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6816592, 16513748, 17015645, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6816592, 16513748, 17015645, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH dehydrogenase" /protein_id="NP_389111.1" /db_xref="EnsemblGenomes-Gn:BSU12290" /db_xref="EnsemblGenomes-Tr:CAB13086" /db_xref="GOA:P80861" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13203" /db_xref="UniProtKB/Swiss-Prot:P80861" /translation="MSKHIVILGAGYGGVLSALTVRKHYTKEQARVTVVNKYPTHQII TELHRLAAGNVSEKAVAMPLEKLFKGKDIDLKIAEVSSFSVDKKEVALADGSTLTYDA LVVGLGSVTAYFGIPGLEENSMVLKSAADANKVFQHVEDRVREYSKTKNEADATILIG GGGLTGVELVGELADIMPNLAKKYGVDHKEIKLKLVEAGPKILPVLPDDLIERATASL EKRGVEFLTGLPVTNVEGNVIDLKDGSKVVANTFVWTGGVQGNPLVGESGLEVNRGRA TVNDFLQSTSHEDVFVAGDSAVYFGPDGRPYPPTAQIAWQMGELIGYNLFAYLEGKTL ETFKPVNSGTLASLGRKDAVAIIGANSTPLKGLPASLMKEASNVRYLTHIKGLFSLAY *" /label="ndh CDS" gene 1179347..1180525 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /label="ndh gene" promotor_no_box 1180356..1180456 /Source="Nicolas_upshift_promotors" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1180414..1180432) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1180416 /Source="Nicolas_upshifts" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1180422) /Source="Nicolas_upshifts" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1180444..1180452) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1180524 /Source="Nicolas_upshifts" /id="D684" /incds=0 /nref=220 /ntot=278 /MaxReadThrough="2.01042" /MaxDrop="8.69373" /score="30.6421047" /energy="-23.1" /TU="NA" /idTUdmin="U1005" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 1180633..1180640 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1180655..1180674 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1180680 /Source="Nicolas_upshifts" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="upshifts" CDS 1180723..1182144 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /EC_number="5.3.1.12" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galacturonate isomerase" /protein_id="NP_389112.1" /db_xref="EnsemblGenomes-Gn:BSU12300" /db_xref="EnsemblGenomes-Tr:CAB13087" /db_xref="GOA:O34808" /db_xref="InterPro:IPR003766" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13204" /db_xref="UniProtKB/Swiss-Prot:O34808" /translation="MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYEN KTFQNITEAWLYGDHYKWRIMRANGIEETYITGDAPDEEKFMAWAKTVPMAIGNPLYN WTHLELQRFFGIYEILNEKSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPV DSLEYHLLLKEDKDFPVSVLPGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFL KALEKRVRFFHSAGGRVSDHAIDTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKT YTLQFLCGLYAELDWAMQFHINALRNTNTKMMKRLGPDTGYDSMNDEEIAKPLYKLLN SVEMKNQLPKTILYSLNPNDNYVIASMINSFQDGITPGKIQFGTAWWFNDTKDGMLDQ MKALSNVGLFSRFIGMLTDSRSFLSYTRHEYFRRIVCNLIGEWVENGEVPRDMELLGS IVQGICYDNAKHYFQFQEEKANV*" /label="uxaC CDS" gene 1180723..1182144 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /label="uxaC gene" CDS 1182212..1183591 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+:altronate/mannonate symporter" /protein_id="NP_389113.1" /db_xref="EnsemblGenomes-Gn:BSU12310" /db_xref="EnsemblGenomes-Tr:CAB13088" /db_xref="GOA:O34961" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13205" /db_xref="UniProtKB/Swiss-Prot:O34961" /translation="MRTELANKVVSVETEKRLSLKEKMSYGFGDFGNGFMFDLGQIYL LKYFTDVAGIPAAMAGGIFLVSKLFAAITDPIVGSSIDYRKNIGKRGKFRPYLLIGSI VLAVLTVLIFLSPNVSTTGKLIYAYASYMIWGIGYSFVNIPYGSLGAAMTQNSEDRTS ISTFRQIGSLGALFITSVAVMPLLVKFDNPKVGYPVVMGLFAALGVFWFYICYRNCKE RIIISEAPKEKLTLSSVVKTFITNKPLLTLVLMTIFSISAYNIKSAMLVYFAQYNLGN VELMAYMNFIIIGSSFLGVVFLPKLVKMFGKKRTAMIGFGISVAADLINFMLPSNVYV FTILASIAFIGISIPNGITWALVSDIIDYGEWKSGERKEATTYSLFNFSRKLAQSLSG FLSGIGLGIIGYVPNAVQTAQALIGIKALLLLYPAIALALAMFIIGFLYKLTDQQHAQ IVQDLHQKS*" /label="exuM CDS" gene 1182212..1183591 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /label="exuM gene" promotor_-10 complement(1182731..1182750) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1182736) /Source="Nicolas_upshifts" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1182764..1182771) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1183616 /Source="Nicolas_upshifts" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1183626..1183633 /Source="Nicolas_upshift_promotors" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1183628..1183695 /Source="Nicolas_S_feature" /locus_tag="new_1303355_1303422" /HighExp="S4, S5, S6, S3, S8, S7, T5.0H, T4.0H, T3.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S452" CDS 1183696..1184709 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655, 16788182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389114.1" /db_xref="EnsemblGenomes-Gn:BSU12320" /db_xref="EnsemblGenomes-Tr:CAB13089" /db_xref="GOA:O34736" /db_xref="InterPro:IPR003767" /db_xref="InterPro:IPR036111" /db_xref="SubtiList:BG13206" /db_xref="UniProtKB/Swiss-Prot:O34736" /translation="MKTITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNV HSHGVLHTEHYVNRLLAGGINPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAID MAKKKGVGMVTAVNSSHCGALSYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTN PIAYGVPAKHKKPFILDMATSKVAFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVV SLSTFGGPKGYGLSIVVDVFSGLLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFF TDWDTFLEQMDAMIDELQQSPPAVGFERVYVPGEIEQLHEERNKKNGISIARSVYEFL KSR*" /label="yjmC CDS" gene 1183696..1184709 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /label="yjmC gene" CDS 1184715..1185734 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389115.1" /db_xref="EnsemblGenomes-Gn:BSU12330" /db_xref="EnsemblGenomes-Tr:CAB13090" /db_xref="GOA:O35045" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13207" /db_xref="UniProtKB/Swiss-Prot:O35045" /translation="MKAVQVRKAYDLVTAEVKKPVLSKDDEVLVKVKRVGICGSDMHI YHGTNPLATLPRVIGHEVTGQVEAVGANVQSLKPGDHVVIEPISYCGSCYACRKGRPN VCAKLSVFGVHEDGGMREYIVLPERQLHAVSKDLPWEEAVMAEPYTIGAQAVWRGQVE KGDTVLIQGAGPIGICVLKMAKLAGAAVMMTDLNNERLAFAKENGADAVVNVQAEHVA ERVLEWTGNEGANVVIDAVCLPETFALSIEAVSPAGHVVVLGFDERAAQISQLPITKK EVTITGSRLQTNQFPKVVELLNGGRLMHNGLVTHTFSVDDVHHAFQFIKEHPDQVRKA VITFD*" /label="yjmD CDS" gene 1184715..1185734 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /label="yjmD gene" CDS 1185759..1186838 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /EC_number="4.2.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9579062, 9882655, 10368143, 25145794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-mannonate dehydratase" /protein_id="NP_389116.1" /db_xref="EnsemblGenomes-Gn:BSU12340" /db_xref="EnsemblGenomes-Tr:CAB13091" /db_xref="GOA:O34346" /db_xref="InterPro:IPR004628" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG13208" /db_xref="UniProtKB/Swiss-Prot:O34346" /translation="MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEK EEIRAETEYIQSYGFHAEVVESVNVHEAIKLGNEERGRYIENYKQTIRNLAGFGVKVI CYNFMPVFDWTRTDMFRPLEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEP EKLARIKELFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLP RIITGEASYKKLRAISDSPSNCITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVK IYENGDFIETSHLTKDGSINIQGVMEELHKQDYEGYVRPDHGRHLWGEQCRPGYGLYD RALGIMYLNGLWDAYEAMAKKEVGI*" /label="uxuA CDS" gene 1185759..1186838 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /label="uxuA gene" CDS 1186835..1187671 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /EC_number="1.1.1.57" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructuronate reductase" /protein_id="NP_389117.1" /db_xref="EnsemblGenomes-Gn:BSU12350" /db_xref="EnsemblGenomes-Tr:CAB13092" /db_xref="GOA:O34896" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13209" /db_xref="UniProtKB/Swiss-Prot:O34896" /translation="MIPLHENLAGKTAVITGGSGVLCSAMARELARHGMKVAILNRTA EKGQAVVKEITAAGGTACAVAADVLDRMSLERAKEDILGQFGAVDLLINGAGGNHPDA ITDVETYEEAGEGQSFFDMDERGFLTVFSTNFTGAFLASQVFGKELLKADSPAIINLS SMSAYSPMTKVPAYSAAKASINNFTMWMAVHFAETGLRVNAIAPGFFLTKQNHDLLIN QDGTFTSRSHKIIAGTPMKRFGKPEDLLGTLLWLADESYSGFVTGITVPVDGGFMAYS GV*" /label="uxuB CDS" gene 1186835..1187671 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /label="uxuB gene" CDS 1187719..1188987 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8320243, 9579062, 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="hexuronate transporter" /protein_id="NP_389118.1" /db_xref="EnsemblGenomes-Gn:BSU12360" /db_xref="EnsemblGenomes-Tr:CAB13093" /db_xref="GOA:O34456" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13210" /db_xref="UniProtKB/Swiss-Prot:O34456" /translation="MFSKDKLPVILFLFLAGVINYLDRSALSIAAPFIQDDLTLSATQ MGLIFSSFSIGYAIFNFLGGVASDRYGAKLTLFVAMVVWSLFSGAVALAFGFVSLLII RILFGMGEGPLSATINKMVNNWFPPTQRASVIGVTNSGTPLGGAISGPIVGMIAVAFS WKVSFVLIMIIGLIWAVLWFKFVKEKPQETIKEAPAIKAETSPGEKIPLTFYLKQKTV LFTAFAFFAYNYILFFFLTWFPSYLVDERGLSVESMSVITVIPWILGFIGLAAGGFVS DYVYKKTARKGVLFSRKVVLVTCLFSSAVLIGFAGLVATTAGAVTLVALSVFFLYLTG AIYWAVIQDVVDQNNVGSVGGFMHFLANTAGIIGPALTGFIVDQTGTFSGAFLLAGGL AVFASLAVIRFVRPIIGKPAGTEAENPVSY*" /label="exuT CDS" gene 1187719..1188987 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /label="exuT gene" promotor_-35 1188931..1188934 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1188950..1188954 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1188952 /Source="Nicolas_upshifts" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1189020..1189039 /Source="Nicolas_upshift_promotors" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1189020 /Source="Nicolas_upshifts" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" CDS 1189075..1190076 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9579062, 9882655" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9579062, 9882655; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_389119.1" /db_xref="EnsemblGenomes-Gn:BSU12370" /db_xref="EnsemblGenomes-Tr:CAB13094" /db_xref="GOA:Q9JMQ1" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13211" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ1" /translation="MVTIKDIAKLANVSHTTVSRALNNSPYIKEHTKKKILELAEQLN YTPNVNAKSLAMQKSHTIGLFFTSITNGTSHSFFADTIKGVNQAISEDYNLYVRGIDD LKNYDSVTPMRYDGIILMSQSDIDNSFIYHIREKNIPLVVLNRDIDDRTITNILSNDK EGSQEAVEYFIQSGHQDIAIIEGIEGFKSSQQRKEGYLSALIQHHIPIKHEYSVKGQY DMESGFQAMERLLALPNPPTAVFCSNDDMAIGAMNAIFAKGLRVPDDISVIGFDDIGF SQYITPRLSTVKRPVEKISVLGAQKLLSLISEPETKAEKILENTEFMVRDSVRRLTT* " /label="exuR CDS" gene 1189075..1190076 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /label="exuR gene" promotor_no_box complement(1189758..1189858) /Source="Nicolas_upshift_promotors" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1189798) /Source="Nicolas_upshifts" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1190052 /Source="Nicolas_upshifts" /id="D685" /incds=0 /nref=2 /ntot=132 /MaxReadThrough="2.47166" /MaxDrop="3.11543" /score="12.2153519" /energy="-7.4" /TU="NA" /idTUdmin="U1011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1190153..1191595 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /EC_number="1.1.1.58" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tagaturonate reductase (altronate oxidoreductase)" /protein_id="NP_389120.1" /db_xref="EnsemblGenomes-Gn:BSU12380" /db_xref="EnsemblGenomes-Tr:CAB13095" /db_xref="GOA:O34354" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023668" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13212" /db_xref="UniProtKB/Swiss-Prot:O34354" /translation="MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTD FNGSVAVVQPRGSEKIKRLNEQDGLYTLFLQGMKDGEAVNEHMIINSISRGIDLFSDY EAYKELASSERLRFIISNTTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGD QTKGCVLIPCELIENNGEKLRETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPG FPVDSIDEITADLGYQDDLIVVGEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTP YRTKKVRILNGAHTAMTPVALLYGLKTVRDAVEHPEVGRFIRELIDDEILPVLKMEGL SQYADDVLNRFKNPYIKHYLESIALNAISKFKTRNLPTLKEYAEQKGQLPERLVFSFS ALLYFYHDNETLQDDPAVLQFFKEVWCQEDGDMLRIASRVLGEQRLWGADLNEIPKLT DRVAVYLNHIHELGMQRALEQYCIQGGEVR*" /label="uxaB CDS" gene 1190153..1191595 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /label="uxaB gene" CDS 1191592..1193085 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /EC_number="4.2.1.7" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="altronate dehydratase" /protein_id="NP_389121.2" /db_xref="EnsemblGenomes-Gn:BSU12390" /db_xref="EnsemblGenomes-Tr:CAB13096" /db_xref="GOA:O34673" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="SubtiList:BG13213" /db_xref="UniProtKB/Swiss-Prot:O34673" /translation="MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHK IALQSIKENDSIVKYGFPIGHASQDISIGEHIHVHNTKTNLSDIQLYSYTPRFDENPY SNENRTFKGFRRENGDAGVRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLV LKHQYGCSQLGDDHENTKQILLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLK RVKFLESQSVTDEMEAGVALLKEIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITA NPLLGRFSDYLIAQGGSTVLTEVPEMFGAETILMQRAANEEVFHKIVDLINDFKQYFI KHDQPVYENPSPGNKAGGISTLEDKSLGCTQKAGISPVTDVLKYGEVLKTKGLTLLSA PGNDLIASSALAAAGCQIVLFTTGRGTPFGTFVPTVKVATNTELYEAKPHWIDFNAGL LAEDDVHEEYVLREFIHYMIEVASGQLVNHEKNDFKELAIFKSGVTL*" /label="uxaA CDS" gene 1191592..1193085 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /label="uxaA gene" CDS complement(1193124..1193888) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389122.1" /db_xref="EnsemblGenomes-Gn:BSU12400" /db_xref="EnsemblGenomes-Tr:CAB13097" /db_xref="GOA:O34578" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13214" /db_xref="UniProtKB/Swiss-Prot:O34578" /modified_by="User" /translation="MSVSIILMGLFVGALVGLTGVGGAALLTPLLIVLGINPSIAVGT DLVYNSITKLFGVASHWRQKTINFKLVKYLAIGGIPSASLAIGILHLFPAFHQHQEEI IKHALGYVLTLVAISIIVRLFLDRKLRPNRWQLMPLENKRALTILIGVVFGFIVGLTS IGSGSLFAIAMIYLFNMKASQIVGTDIAHAFLLVTAAGILNASFGSVDYMLAANLLLG SIPGVLIGSHLSPRFSPRPLQFIMASIILVSGLKLI*" /label="Delta6_BSU_12400_SNPvariant" gene complement(1193124..1193888) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /modified_by="User" /label="Delta6_BSU_12400_SNPvariant" downshifts complement(1193143) /Source="Nicolas_upshifts" /id="D686" /incds=0 /nref=96 /ntot=170 /MaxReadThrough="1.34004" /MaxDrop="4.60564" /score="6.47747687" /energy="-11.3" /TU="NA" /idTUdmin="U1015" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" Polymorphism join(1193656,1193658) /Source="geneious" /ID="SNP_BsDelta6_1313384_1313384" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="S -> G" /CDS_Position=232 /Change="T -> C" /Codon_Change="AGT -> GGT" /Coverage=150 /locus_tag="BSU_12400" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=149 /comment="Delta6_BSU_12400_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" SCAR join(1193915,1193922) /created_by="User" /modified_by="User" /label="TF8A" N_region 1193916..1193921 /created_by="User" /note_="EcoRI site (GAATTC)" /modified_by="User" /label="TF8A" CDS <1193924..1194244 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /EC_number="3.5.1.28" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7921239, 9555893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921239, 9555893; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_389164.1" /db_xref="EnsemblGenomes-Gn:BSU12810" /db_xref="EnsemblGenomes-Tr:CAB13138" /db_xref="GOA:P39800" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="InterPro:IPR036779" /db_xref="PDB:3HMB" /db_xref="PDB:3RDR" /db_xref="SubtiList:BG10962" /db_xref="UniProtKB/Swiss-Prot:P39800" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /translation="PNLIRVGQVLIVSAPSAAEKPELYPLPDGIIQLTTPYTSGEHVF QVQRALAALYFYPDKGAVNNGIDGVYGPKTADAVARFQSVNGLTADGIYGPATKEKIA AQLS*" /label="Delta6_pseudo_BSU_12810" gene <1193924..1194244 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /label="Delta6_pseudo_BSU_12810" downshifts 1194253 /Source="Nicolas_upshifts" /id="D696" /incds=0 /nref=29 /ntot=162 /MaxReadThrough="3.77255" /MaxDrop="5.00305" /score="30.9009227" /energy="-12.5" /TU="U1029,U1033" /idTUdmin="U1029" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" S_feature complement(1194262..1194465) /Source="Nicolas_S_feature" /locus_tag="new_1348200_1348403_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.798" /TUlongSig="NA" /TUlongPSig="NA" /label="S458" CDS complement(1194281..1194418) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type r: regulator" /codon_start=1 /transl_table=11 /product="three component toxin / antitoxin / antitoxin SpoIISABC, antitoxin C" /protein_id="YP_009513952.1" /translation="MSGDTVKKLVRRVKFVDYGRFGLSGYSLRVRERSAGIIKKLKKK K*" /label="spoIISC CDS" gene complement(1194281..1194418) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /label="spoIISC gene" downshifts complement(1194305) /Source="Nicolas_upshifts" /id="D697" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="2.75573" /MaxDrop="4.3776" /score="24.0186344" /energy="-12.5" /TU="U1034" /idTUdmin="U1035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1194504..1194674) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptotic control system component B (antitoxin B)" /protein_id="NP_389165.1" /db_xref="EnsemblGenomes-Gn:BSU12820" /db_xref="EnsemblGenomes-Tr:CAB13139" /db_xref="GOA:O34800" /db_xref="InterPro:IPR025897" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12678" /db_xref="UniProtKB/Swiss-Prot:O34800" /translation="MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKEN ERLIDEYKRKKA*" /label="spoIISB CDS" gene complement(1194504..1194674) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /label="spoIISB gene" downshifts complement(1194510) /Source="Nicolas_upshifts" /id="D698" /incds=0 /nref=6 /ntot=86 /MaxReadThrough="4.69899" /MaxDrop="3.0872" /score="24.0186344" /energy="-12.5" /TU="U1034,U1035" /idTUdmin="U1035" /TUdmin="-205" /isTUend="FALSE" /label="downshifts" CDS complement(1194674..1195420) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptosis factor (ABC toxin/antitoxin/antitoxin system)" /protein_id="NP_389166.1" /db_xref="EnsemblGenomes-Gn:BSU12830" /db_xref="EnsemblGenomes-Tr:CAB13140" /db_xref="GOA:O34853" /db_xref="InterPro:IPR025940" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12677" /db_xref="UniProtKB/Swiss-Prot:O34853" /translation="MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLL FVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAFIFLSAYVKKLAGSELETDTREI LEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSD SIVTEFDYLLFTSLTSIYDLVLPIEEEGEG*" /label="spoIISA CDS" gene complement(1194674..1195420) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /label="spoIISA gene" promotor_-10 complement(1195255..1195274) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1195272) /Source="Nicolas_upshifts" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1195290..1195297) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1195446..1195464) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1195459) /Source="Nicolas_upshifts" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1195480..1195485) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1195530..1196531) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10784039, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative low-affinity inorganic phosphate transporter" /protein_id="NP_389167.2" /db_xref="EnsemblGenomes-Gn:BSU12840" /db_xref="EnsemblGenomes-Tr:CAB13141" /db_xref="GOA:O34436" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13226" /db_xref="UniProtKB/Swiss-Prot:O34436" /translation="MDILLILTILIVICALAFDFINGFHDTANAIATSVSTKALKPRH AIILAAVMNFVGAMTFTGVAKTITKDIVDPYTLENGSVVILAALLAAIAWNLITWYYG IPSSSSHAIIGAIAGAAIAAAGFAALNYKGFIKIIEALILSPIIAFVLGFILYSIVKL IFKDSNLAKTNKQFRRVQIVTAALQSYTHGTNDAQKAMGIITMALITANLHTSANDIP TWVQFACATAMGLGTSIGGWKIIKTVGGKIMKIRPVNGVSADLTGAAIIFGATFIHLP VSTTHVISSSILGVGASHRVKGVNWGTAKRMLITWVITLPISATLGAIAYFILNMIF* " /label="pitB CDS" gene complement(1195530..1196531) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /label="pitB gene" downshifts complement(1195559) /Source="Nicolas_upshifts" /id="D699" /incds=0 /nref=205 /ntot=253 /MaxReadThrough="3.49591" /MaxDrop="5.81942" /score="21.8061263" /energy="-11" /TU="U1036,U1038" /idTUdmin="U1037" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1196544..1197161) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696772, 14563871; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PitB transporter accessory protein" /protein_id="NP_389168.1" /db_xref="EnsemblGenomes-Gn:BSU12850" /db_xref="EnsemblGenomes-Tr:CAB13142" /db_xref="InterPro:IPR018445" /db_xref="SubtiList:BG13225" /db_xref="UniProtKB/Swiss-Prot:O34454" /translation="MIRRKKDKFSLLLTEIAKNIDETAEYFVNFKVTNQTTLKEFADT LKEYETKGDNHVHVMIKELNKAFITPIEREDILQLTNSLDDVLDGIEHFSAMMEIFSI TSSDEHIDKFSGYIRECAKEILITIELLAENRLKDIQPHAIKIKEYEHSCDNLHRKSL KNLFGNETDPIKVIQYREIYETLEEIADSCQSVANNLETIIMKNA*" /label="ykaA CDS" gene complement(1196544..1197161) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /label="ykaA gene" promotor_-10 complement(1197197..1197216) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1197199) /Source="Nicolas_upshifts" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1197201..1197298) /Source="Nicolas_S_feature" /locus_tag="new_1351139_1351236_c" /HighExp="H2O2, Etha, dia15, Diami, Paraq, Heat, dia5, Salt, LBGstat, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.972, 0.987" /TUlongSig="SigA" /TUlongPSig="0.992" /label="S459" promotor_-35 complement(1197232..1197236) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1197278..1197297) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1197298) /Source="Nicolas_upshifts" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1197312..1197319) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1197343..1197362) /Source="Nicolas_upshift_promotors" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1197355) /Source="Nicolas_upshifts" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1197437..1198753) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17344220, 19419962, 20610400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17344220, 19419962, 20610400; Product type t : transporter" /codon_start=1 /transl_table=11 /product="serine / threonine exchanger" /protein_id="NP_389169.1" /db_xref="EnsemblGenomes-Gn:BSU12860" /db_xref="EnsemblGenomes-Tr:CAB13143" /db_xref="GOA:O34739" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG13227" /db_xref="UniProtKB/Swiss-Prot:O34739" /translation="MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDS KMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYTYLEEVYGEFWGFLCGWVQIIIY GPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTI GKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEM KNPEKLLPRAMTGGLLIVTAIYIFINFALLHILSANEIVTLGENATSTAATMLFGSIG GKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSHVHPSFRTPWIAISF QIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFM PILAIAGSFFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS*" /label="steT CDS" gene complement(1197437..1198753) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /label="steT gene" downshifts complement(1197452) /Source="Nicolas_upshifts" /id="D700" /incds=0 /nref=3 /ntot=92 /MaxReadThrough="3.59461" /MaxDrop="3.97157" /score="23.3119204" /energy="-14.4" /TU="U1039" /idTUdmin="U1039" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1198800..1198819) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-10" upshifts complement(1198816) /Source="Nicolas_upshifts" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="upshifts" promotor_-35 complement(1198834..1198837) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-35" promotor_-35 1199036..1199043 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1199058..1199077 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1199070..1199141 /Source="Nicolas_S_feature" /locus_tag="new_1353008_1353079" /HighExp="Etha, dia15, Salt, Heat, dia5, Diami, H2O2, M9-stat, MG 25, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.964" /TUlongSig="NA" /TUlongPSig="NA" /label="S460" upshifts 1199070 /Source="Nicolas_upshifts" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="upshifts" CDS 1199142..1200092 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /EC_number="1.13.11.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17407181, 17725564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 17725564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroquinone-specific extradiol dioxygenase" /protein_id="NP_389170.1" /db_xref="EnsemblGenomes-Gn:BSU12870" /db_xref="EnsemblGenomes-Tr:CAB13144" /db_xref="GOA:O34689" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13228" /db_xref="UniProtKB/Swiss-Prot:O34689" /translation="MKVNGIHHVSALTADAQKNLDFYKKVLGLKLVKKSVNQDEPTMY HLFYGDEVANPGTELTFFEIPRIAPFHAGTNSISSIGLRVPGTEALHYWKERFEEQQV THSGISKRAGRDILAFQDHEGQRLVLTADEEGKGYGLPVKQSGIPEEFSFRGLGPVEL TVPYAEPTLHVLTNILGFTEISREPVEGQGTAVILESGEGGAATEIHLIERNDLPRER QGKGSVHHVAFRVRDEEELAGWHRIISREGFSNSGIVERYYFKALYFREPNGILFELS TDGPGFMVDENLDELGQTIALPPYLEHRRAEIEAKLKPIQ*" /label="mhqA CDS" gene 1199142..1200092 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /label="mhqA gene" downshifts 1200080 /Source="Nicolas_upshifts" /id="D701" /incds=0 /nref=95 /ntot=231 /MaxReadThrough="0.70251" /MaxDrop="5.11652" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1040" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 1200193..1200339 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513953.1" /translation="MLIGRNGLKPFANMGDWYGMASAKILSLFINSLFIFACYTISKL DKKE*" /label="hypothetical protein CDS" gene 1200193..1200339 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /label="gene" CDS 1200347..1202497 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane glycosyl transferase" /protein_id="NP_389171.2" /db_xref="EnsemblGenomes-Gn:BSU12880" /db_xref="EnsemblGenomes-Tr:CAB13145" /db_xref="GOA:O34575" /db_xref="SubtiList:BG13229" /db_xref="UniProtKB/Swiss-Prot:O34575" /translation="MEKKKRELDIVLLLILLASAFLNIYNIWKDDTVNPYYTAAVTSM MQSFHNFFYASFDAAGFITVDKPPVTYQIQTISALIFGMHGWSVILPQALAGVGSVLL MYLLIKPTFGKTAARIASFVMACTPIAVAVARTNNVDALLVFFLLLATWLLFKAIRKG KLIWLLAAFFVVGVGFNTKMLQAYMILPAFLLFYLIAANATIKKKIVSLVSALAVLAA VSLSWPLIVDNIPASKRPYIGSSQTNSVLELAFGYNGIQRLTGQNSGGGQGAPNKDAS KEMSSSDNTQAPPNQSSSNSSSSDGKSSNGNMAAPPSNGQMPSGGQGGPPSGGDGGQG GPGGDGGKGGTGTGSKMQSGSGMFGTGTPGPLRLFQQELSDQISWLLPFAIFGIAGLL IAGARERRRLSVEQKETVFWVAWLVPIAGFFSVAEFFHHYYLIMLAPPIAALVGAGWV ALVHLYRNQTGWKAWLLPGAIIATTGFELFILRNYNDQIGVGWSIGVGVIGVLSAIAL LLFKQRQKPFSYYVSLAALLALLVMPMYWASTPLLYGGNSSLPETGPQLASMSGKGMG MSDATVNEKLIKYLEENNSGAEYLFATTDSNTAAPYIIKTKKAVMAIGGYSGSDPAIT LTQFKKLVKEGKVKYFLASGMGRGGNNDIVEWVEKNGKEVASEKWQSSSDQKTENTDS ADTSSSKASGENGKMGGPGGMNQSATLYELHADE*" /label="ykcB CDS" gene 1200347..1202497 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /label="ykcB gene" promotor_no_box 1201236..1201336 /Source="Nicolas_upshift_promotors" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1201296 /Source="Nicolas_upshifts" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1201384 /Source="Nicolas_upshifts" /id="D702" /incds=1 /nref=4 /ntot=10 /MaxReadThrough="0.56615" /MaxDrop="4.44711" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1041" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1202509..1203480 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /EC_number="2.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389172.2" /db_xref="EnsemblGenomes-Gn:BSU12890" /db_xref="EnsemblGenomes-Tr:CAB13146" /db_xref="GOA:O34319" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13230" /db_xref="UniProtKB/Swiss-Prot:O34319" /translation="MSRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVN DGSKDRSIEILREHSLIDPRVKIIDFSRNFGHQIAITAGMDYAQGNAIVVIDADLQDP PELILEMIEKWKEGYEVVYAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDF RLMDRKVCDEMKRLKEKNPFVRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLS MDGITTFSHKPLKLASYAGILMSGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFS GIVLLILGVIGEYIGRIYDEAKDRPLYIVQKSYGIENKRLYRDQHMS*" /label="ykcC CDS" gene 1202509..1203480 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /label="ykcC gene" S_feature complement(1202837..1203478) /Source="Nicolas_S_feature" /locus_tag="new_1356775_1357416_c" /HighExp="T-0.40H, T0.0H, Salt, T0.30H, T-1.10H, C30, T-1.40H, S0, H2O2, T1.0H" /AntisenseName="ykcC" /AntisenseCor="9.6017422892053297E-4" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S461" downshifts complement(1203523) /Source="Nicolas_upshifts" /id="D703" /incds=0 /nref=9 /ntot=114 /MaxReadThrough="4.36795" /MaxDrop="4.15844" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=489 /isTUend="FALSE" /label="downshifts" S_feature complement(1203548..1203914) /Source="Nicolas_S_feature" /locus_tag="new_1357486_1357852_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T0.0H, T2.30H, T-0.40H, T3.0H, Salt, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99893799999999999" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S462" downshifts complement(1203591) /Source="Nicolas_upshifts" /id="D704" /incds=0 /nref=17 /ntot=157 /MaxReadThrough="6.61192" /MaxDrop="3.74411" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=421 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1203894..1203909) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1203914) /Source="Nicolas_upshifts" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1203921..1203930) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1203998..1205347) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /EC_number="3.4.21.107" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 11555295, 12823817, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 11555295, 12823817, 24362423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound serine protease Do, quality control protease and chaperone (heat-shock protein)" /protein_id="NP_389173.2" /db_xref="EnsemblGenomes-Gn:BSU12900" /db_xref="EnsemblGenomes-Tr:CAB13147" /db_xref="GOA:O34358" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG12608" /db_xref="UniProtKB/Swiss-Prot:O34358" /translation="MDNYRDENRTKGNENEVFLTKENDQSASYSARNVIHDQEKKKRG FGWFRPLLGGVIGGSLALGIYTFTPLGDHDSQDTAKQSSSQQQTQSVTATSTSSESKK SSSSSSAFKSEDSSKISDMVEDLSPAIVGITNLQAQSNSSLFGSSSSDSSEDTESGSG SGVIFKKENGKAYIITNNHVVEGASSLKVSLYDGTEVTAKLVGSDSLTDLAVLQISDD HVTKVANFGDSSDLRTGETVIAIGDPLGKDLSRTVTQGIVSGVDRTVSMSTSAGETSI NVIQTDAAINPGNSGGPLLNTDGKIVGINSMKISEDDVEGIGFAIPSNDVKPIAEELL SKGQIERPYIGVSMLDLEQVPQNYQEGTLGLFGSQLNKGVYIREVASGSPAEKAGLKA EDIIIGLKGKEIDTGSELRNILYKDAKIGDTVEVKILRNGKEMTKKIKLDQKEEKTS* " /label="htrA CDS" gene complement(1203998..1205347) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /label="htrA gene" downshifts complement(1204012) /Source="Nicolas_upshifts" /id="D705" /incds=0 /nref=198 /ntot=244 /MaxReadThrough="2.95586" /MaxDrop="5.35972" /score="30.7234179" /energy="-19.9" /TU="NA" /idTUdmin="U1044" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1205387..1205394 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-35" promotor_-10 complement(1205399..1205418) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1205407 /Source="Nicolas_upshifts" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="upshifts" promotor_-10 1205409..1205428 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-10" upshifts complement(1205417) /Source="Nicolas_upshifts" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1205419..1205501) /Source="Nicolas_S_feature" /locus_tag="new_1359357_1359439_c" /HighExp="Etha, dia5, S8, S6, T2.0H, T3.30H, dia15, T5.0H, BC, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.682" /TUlongSig="NA" /TUlongPSig="NA" /label="S463" promotor_-35 complement(1205429..1205436) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1205458..1205464 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1205479..1205498 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1205482 /Source="Nicolas_upshifts" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1205484..1205503) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1205501) /Source="Nicolas_upshifts" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1205516..1206334 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /EC_number="1.5.1.2" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redundant pyrroline-5-carboxylate reductase" /protein_id="NP_389174.1" /db_xref="EnsemblGenomes-Gn:BSU12910" /db_xref="EnsemblGenomes-Tr:CAB13148" /db_xref="GOA:Q00777" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10841" /db_xref="UniProtKB/Swiss-Prot:Q00777" /translation="MEQIGLIGYGSMADMIARQLLKHEQIKENELFIETRTKGERLRA LMSDYPNVSADPLENWANTCQLILICVPPLHVIETMRRLYPYVNRNTHIVSIAAGVPL RLLEAETEAGISRVIPAITSEAEAGISLVVHSEALAAEKKERLNELLSVFSRVREIKE SNLDVASNLTSSAPGFIAAIFEELALSAVRNSSLSKEEAFDFLIHSLYGTGKMLIEKN MSFEETLERVATKGGITGEGAEVIHASVPDVFDEVFERTLRKYELLTEQVGKQT*" /label="proCC CDS" gene 1205516..1206334 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /label="proCC gene" promotor_-35 complement(1205519..1205522) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1206312 /Source="Nicolas_upshifts" /id="D706" /incds=0 /nref=90 /ntot=220 /MaxReadThrough="1.3818" /MaxDrop="4.43155" /score="-5.08770006" /energy="-5.3" /TU="NA" /idTUdmin="U1045" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1206391..1206398 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1206413..1206432 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1206417 /Source="Nicolas_upshifts" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1206463..1207287 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11069674, 11473256, 19340926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069674, 11473256, 19340926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-aminopeptidase" /protein_id="NP_389175.2" /db_xref="EnsemblGenomes-Gn:BSU12920" /db_xref="EnsemblGenomes-Tr:CAB13149" /db_xref="GOA:P26902" /db_xref="InterPro:IPR007035" /db_xref="InterPro:IPR027476" /db_xref="InterPro:IPR033824" /db_xref="InterPro:IPR036177" /db_xref="PDB:1HI9" /db_xref="SubtiList:BG10842" /db_xref="UniProtKB/Swiss-Prot:P26902" /translation="MKLYMSVDMEGISGLPDDTFVDSGKRNYERGRLIMTEEANYCIA EAFNSGCTEVLVNDSHSKMNNLMVEKLHPEADLISGDVKPFSMVEGLDDTFRGALFLG YHARASTPGVMSHSMIFGVRHFYINDRPVGELGLNAYVAGYYDVPVLMVAGDDRAAKE AEELIPNVTTAAVKQTISRSAVKCLSPAKAGRLLTEKTAFALQNKDKVKPLTPPDRPV LSIEFANYGQAEWANLMPGTEIKTGTTTVQFQAKDMLEAYQAMLVMTELAMRTSFC*" /label="dppA CDS" gene 1206463..1207287 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /label="dppA gene" CDS 1207304..1208230 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389176.1" /db_xref="EnsemblGenomes-Gn:BSU12930" /db_xref="EnsemblGenomes-Tr:CAB13150" /db_xref="GOA:P26903" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10843" /db_xref="UniProtKB/Swiss-Prot:P26903" /translation="MARYMIKRFWAMAATILVITTLTFVLMKVIPGSPFNEERGTNEA VQKNLEAYYHLDDPLIFQYIFYLKSIITFDFGPSIKKPSDSVNDMLERGFPVSFELGM TAIVIAVISGLVLGVIAALRRNGFLDYAAMSLAVLGISIPNFILATLLIQQFAVNLKL FPAATWTSPIHMVLPTAALAVGPMAIIARLTRSSMVEVLTQDYIRTAKAKGLSPFKII VKHALRNALMPVITVLGTLVASILTGSFVIEKIFAIPGMGKYFVESINQRDYPVIMGT TVFYSVILIIMLFLVDLAYGLLDPRIKLHKKG*" /label="dppB CDS" gene 1207304..1208230 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /label="dppB gene" CDS 1208236..1209198 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389177.1" /db_xref="EnsemblGenomes-Gn:BSU12940" /db_xref="EnsemblGenomes-Tr:CAB13151" /db_xref="GOA:P26904" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10844" /db_xref="UniProtKB/Swiss-Prot:P26904" /translation="MNLPVQTDERQPEQHNQVPDEWFVLNQEKNREADSVKRPSLSYT QDAWRRLKKNKLAMAGLFILLFLFVMAVIGPFLSPHSVVRQSLTEQNLPPSADHWFGT DELGRDVFTRTWYGARISLFVGVMAALIDFLIGVIYGGVAGYKGGRIDSIMMRIIEVL YGLPYLLVVILLMVLMGPGLGTIIVALTVTGWVGMARIVRGQVLQIKNYEYVLASKTF GAKTFRIIRKNLLPNTMGAIIVQMTLTVPAAIFAESFLSFLGLGIQAPFASWGVMAND GLPTILSGHWWRLFFPAFFISLTMYAFNVLGDGLQDALDPKLRR*" /label="dppC CDS" gene 1208236..1209198 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /label="dppC gene" promotor_-35 1208930..1208935 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1208951..1208969 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1208952 /Source="Nicolas_upshifts" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1209203..1210210 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7536291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7536291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (ATP-binding subunit)" /protein_id="NP_389178.1" /db_xref="EnsemblGenomes-Gn:BSU12950" /db_xref="EnsemblGenomes-Tr:CAB13152" /db_xref="GOA:P26905" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10845" /db_xref="UniProtKB/Swiss-Prot:P26905" /translation="MEKVLSVQNLHVSFTTYGGTVQAVRGVSFDLYKGETFAIVGESG CGKSVTSQSIMGLLPPYSAKVTDGRILFKNKDLCRLSDKEMRGIRGADISMIFQDPMT ALNPTLTVGDQLGEALLRHKKMSKKAARKEVLSMLSLVGIPDPGERLKQYPHQFSGGM RQRIVIAMALICEPDILIADEPTTALDVTIQAQILELFKEIQRKTDVSVILITHDLGV VAQVADRVAVMYAGKMAEIGTRKDIFYQPQHPYTKGLLGSVPRLDLNGAELTPIDGTP PDLFSPPPGCPFAARCPNRMVVCDRVYPGQTIRSDSHTVNCWLQDQRAEHAVLSGDAK D*" /label="dppD CDS" gene 1209203..1210210 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /label="dppD gene" CDS 1210213..1211862 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7783641, 8793880, 11390694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783641, 8793880, 11390694; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (dipeptide-binding lipoprotein)" /protein_id="NP_389179.2" /db_xref="EnsemblGenomes-Gn:BSU12960" /db_xref="EnsemblGenomes-Tr:CAB13153" /db_xref="GOA:P26906" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10846" /db_xref="UniProtKB/Swiss-Prot:P26906" /translation="MKRGKRMKRVKKLWGMGLALGLSFALMGCTANEQAGKEGSHDKA KTSGEKVLYVNNENEPTSFDPPIGFNNVSWQPLNNIMEGLTRLGKDHEPEPAMAEKWS VSKDNKTYTFTIRENAKWTNGDPVTAGDFEYAWKRMLDPKKGASSAFLGYFIEGGEAY NSGKGKKDDVKVTAKDDRTLEVTLEAPQKYFLSVVSNPAYFPVNEKVDKDNPKWFAES DTFVGNGPFKLTEWKHDDSITMEKSDTYWDKDTVKLDKVKWAMVSDRNTDYQMFQSGE LDTAYVPAELSDQLLDQDNVNIVDQAGLYFYRFNVNMEPFQNENIRKAFAMAVDQEEI VKYVTKNNEKPAHAFVSPGFTQPDGKDFREAGGDLIKPNESKAKQLLEKGMKEENYNK LPAITLTYSTKPEHKKIAEAIQQKLKNSLGVDVKLANMEWNVFLEDQKALKFQFSQSS FLPDYADPISFLEAFQTGNSMNRTGWANKEYDQLIKQAKNEADEKTRFSLMHQAEELL INEAPIIPVYFYNQVHLQNEQVKGIVRHPVGYIDLKWADKN*" /label="dppE CDS" gene 1210213..1211862 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /label="dppE gene" downshifts 1211856 /Source="Nicolas_upshifts" /id="D707" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="6.73127" /MaxDrop="3.5888" /score="22.838155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-4469" /isTUend="FALSE" /label="downshifts" CDS 1211950..1212909 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /EC_number="3.4.17.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10428950, 15101989, 18535144, 20944232, 24123814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="muropeptide L,D-carboxypeptidase" /protein_id="NP_389180.2" /db_xref="EnsemblGenomes-Gn:BSU12970" /db_xref="EnsemblGenomes-Tr:CAB13154" /db_xref="GOA:O34851" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13231" /db_xref="UniProtKB/Swiss-Prot:O34851" /translation="MKGVFSLNYKPKALNKGDTVGVIAPASPPDPKKLDTALLFLEEL GLQVKLGKALKNQHGYLAGQDDERLADLHEMFRDDEVKAVLCACGGFGTGRIAAGIDF SLIRKHPKIFWGYSDITFLHTAIHQNTGLVTFHGPMLSTDIGLDDVHPLTKASYKQLF QETEFTYTEELSPLTELVPGKAEGELVGGNLSLLTSTLGTPFEIDTRGKLLFIEDIDE EPYQIDRMLNQLKMGGKLTDAAGILVCDFHNCVPVKREKSLSLEQVLEDYIISAGRPA LRGFKIGHCSPSIAVPIGAKAAMNTAEKTAVIEAGVSEGALKT*" /label="ldcA CDS" gene 1211950..1212909 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /label="ldcA gene" CDS 1212906..1214006 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /EC_number="5.1.1.20" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11747447, 11747448, 15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11747447, 11747448, 15101989; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-Ala-D/L-Glu epimerase" /protein_id="NP_389181.1" /db_xref="EnsemblGenomes-Gn:BSU12980" /db_xref="EnsemblGenomes-Tr:CAB13155" /db_xref="GOA:O34508" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:1JPM" /db_xref="PDB:1TKK" /db_xref="SubtiList:BG13232" /db_xref="UniProtKB/Swiss-Prot:O34508" /translation="MKIIRIETSRIAVPLTKPFKTALRTVYTAESVIVRITYDSGAVG WGEAPPTLVITGDSMDSIESAIHHVLKPALLGKSLAGYEAILHDIQHLLTGNMSAKAA VEMALYDGWAQMCGLPLYQMLGGYRDTLETDYTVSVNSPEEMAADAENYLKQGFQTLK IKVGKDDIATDIARIQEIRKRVGSAVKLRLDANQGWRPKEAVTAIRKMEDAGLGIELV EQPVHKDDLAGLKKVTDATDTPIMADESVFTPRQAFEVLQTRSADLINIKLMKAGGIS GAEKINAMAEACGVECMVGSMIETKLGITAAAHFAASKRNITRFDFDAPLMLKTDVFN GGITYSGSTISMPGKPGLGIIGAALLKGEKEQ*" /label="aeeB CDS" gene 1212906..1214006 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /label="aeeB gene" CDS 1214003..1214893 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989, 20944232" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 20944232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamyl-L-diaminoacid endopeptidase" /protein_id="NP_389182.2" /db_xref="EnsemblGenomes-Gn:BSU12990" /db_xref="EnsemblGenomes-Tr:CAB13156" /db_xref="GOA:O35010" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG13233" /db_xref="UniProtKB/Swiss-Prot:O35010" /translation="MMHTVISAVANIWTAPDSPRPSDQFMLQPTVMIRDWLERMTYDE RLGLCTDNVIQTQVLFGEKVLVTAEQGEWVSVIVPSQPSRKDPRGYPGWMKKYQLEKT KPIHTQHDVMISKPAAFLYRSNGEKEIELSFLTVLPLIAKENGYFKVSTVFGERFVRQ SDAVPVSQQKGTAEDIIQTGAFFLGLPYLWGGISGFGFDCSGFMYSIFKANGYSIPRD AGDQAKAGKGVPLDDMKAGDLLFFAYEEGKGAIHHVGLYVGGGKMLHSPKTGKSIEIL TLTETIYEKELCAVRRCFSE*" /label="eepC CDS" gene 1214003..1214893 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /label="eepC gene" CDS 1214906..1215895 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cell wall oligopeptide ABC transporter (ATP binding protein)" /protein_id="NP_389183.2" /db_xref="EnsemblGenomes-Gn:BSU13000" /db_xref="EnsemblGenomes-Tr:CAB13157" /db_xref="GOA:C0SP98" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13234" /db_xref="UniProtKB/Swiss-Prot:C0SP98" /translation="MRRLPLLEVSQLKMHFDAGKKRTVKAVDGVTFQIREGETFGLVG ESGCGKSTLGRVLMRLYQPTEGSVTYRGTNLHALSEKEQFAFNRKLQMIFQDPYASLN PRMTVREIILEPMEIHNLYNTHKARLLVVDELLEAVGLHPDFGSRYPHEFSGGQRQRI GIARALSLNPEFIVADEPISALDVSVQAQVVNLLKRLQKEKGLTFLFIAHDLSMVKHI SDRIGVMYLGHMMEITESGTLYREPLHPYTKALLSSIPIPDPELEDKRERILLKGELP SPVNPPSGCVFRTRCPEAMPECGESRPQLQEIEPGRFVACHLYRNAETKEKVR*" /label="ykfD CDS" gene 1214906..1215895 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /label="ykfD gene" S_feature complement(1215189..1215916) /Source="Nicolas_S_feature" /locus_tag="new_1369127_1369854_c" /HighExp="Etha, S7, Gly, M40t90, C30, H2O2, M0t90, dia15, T1.0H, S8" /AntisenseName="ykfD" /AntisenseCor="-6.3474114158352593E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S464" downshifts 1215885 /Source="Nicolas_upshifts" /id="D708" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="5.08319" /MaxDrop="3.1399" /score="-3.10371155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" S_feature 1215930..1217098 /Source="Nicolas_S_feature" /locus_tag="new_1369868_1371036" /HighExp="T3.30H, T4.0H, T3.0H, T5.0H, T2.30H, T2.0H, S1, M9-stat, T1.30H, HiOs" /AntisenseName="ykgB" /AntisenseCor="-0.33524952291190102" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S465" CDS complement(1215938..1216987) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /EC_number="3.1.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22960854, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconolactonase" /protein_id="NP_389184.1" /db_xref="EnsemblGenomes-Gn:BSU13010" /db_xref="EnsemblGenomes-Tr:CAB13158" /db_xref="GOA:O34499" /db_xref="InterPro:IPR011048" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019405" /db_xref="SubtiList:BG13236" /db_xref="UniProtKB/Swiss-Prot:O34499" /translation="MTKYIGYVGTYTKGGSEGIYSFELDTEKKALSEPKLAAKLGNPT YVATNKNNTILYSIEKADGQGGVAAYQIDKNSGELTFLNHQLIDGPSPCHVSVDDQNQ FVLTANYHSGKVHVFPVQEDGSLQSPVSEAAHTGKGPHERQEKPHTHYAGFTPEHNYV VAVDLGIDKLYTYKLKDGVLTESGSHSFAPGAGPRHIAFHPKEKYAYVMTELSNEVIA LEYNPTAGEFREIQVVSAIPDDFTDNSQGSAIHVTQDGRFVYVANRGHDSIAVFEVNQ YSGELAFVERVSTEGNWPRDFVFDPTEGFLVASNEETGNLVLFERDKETGRLTLLPST VSVPYPVCVKFLHQV*" /label="pgl CDS" gene complement(1215938..1216987) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /label="pgl gene" downshifts complement(1215961) /Source="Nicolas_upshifts" /id="D709" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="5.12776" /MaxDrop="6.0668" /score="24.6986564" /energy="-15.6" /TU="U1050" /idTUdmin="U1049" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1217014..1217033) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1217025) /Source="Nicolas_upshifts" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1217048..1217055) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1217077..1217937) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /EC_number="3.5.3.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27258038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N(G),N(G)-dimethylarginine dimethylaminohydrolase" /protein_id="NP_389185.2" /db_xref="EnsemblGenomes-Gn:BSU13020" /db_xref="EnsemblGenomes-Tr:CAB13159" /db_xref="GOA:O34497" /db_xref="InterPro:IPR033199" /db_xref="SubtiList:BG13235" /db_xref="UniProtKB/Swiss-Prot:O34497" /translation="MDVSIPKSQHKTVCRTEYGTLQKVILCKPEHMTIKDVINETQKH FEDDNIHVKTANDQHSRLVEALRSHNVEVVLLPVRDGLPEQVFTRDIGFVIGEKAFLS SMTEPIRQGEEAVIKDFFHSQGISYTRMLDTSIEGGDVIIDDDIVYVGISQRTDISAI GQLEEALPEYTIVPVKLHEKFLHLDCVFNIISESEALIYSQAIEPDAADMLAKRYDLI EVPEDEQFTLGTNVLSIGKKTIISLPGNRHVNQQLSKRGYHIIEIDLSEIIKSGGSFR CCTMPLIRGE*" /label="ddaH CDS" gene complement(1217077..1217937) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /label="ddaH gene" promotor_-10 complement(1217962..1217980) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1217979) /Source="Nicolas_upshifts" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1217996..1218002) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1218011..1218018 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1218032..1218051 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1218039 /Source="Nicolas_upshifts" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="upshifts" CDS 1218097..1218615 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /EC_number="3.1.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12426338, 18247525, 24623648, 24722906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acyl-CoA thioesterase" /protein_id="NP_389186.2" /db_xref="EnsemblGenomes-Gn:BSU13030" /db_xref="EnsemblGenomes-Tr:CAB13160" /db_xref="GOA:P49851" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR033120" /db_xref="SubtiList:BG11417" /db_xref="UniProtKB/Swiss-Prot:P49851" /translation="METPETRFCKESKVVKTSRVFPLDTNNHNTLFGGKLMSYIDDIA SISAARHCRRETVTASMDSVDFLKPIGQKDSVCLESYVTWVGTSSMEVFVKVIKEHLM TGERELAATSFLTFVALDSNGKPVPVPRVVPETEEEIMLHNTAVQRANERKNRKRHSQ ALANALGTDKPW*" /label="ykhA CDS" gene 1218097..1218615 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /label="ykhA gene" downshifts 1218606 /Source="Nicolas_upshifts" /id="D710" /incds=0 /nref=34 /ntot=265 /MaxReadThrough="4.66856" /MaxDrop="4.77681" /score="24.0889455" /energy="-10.9" /TU="U1051" /idTUdmin="U1051" /TUdmin="-1436" /isTUend="FALSE" /label="downshifts" promotor_-35 1218680..1218686 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-35" S_feature 1218698..1218804 /Source="Nicolas_S_feature" /locus_tag="new_1372636_1372742" /HighExp="Etha, S5, S6, S8, nit, S7, ferm, S4, dia15, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S466" upshifts 1218698 /Source="Nicolas_upshifts" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="upshifts" promotor_-10 1218700..1218711 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-10" promotor_-35 1218779..1218782 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1218798..1218817 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1218806 /Source="Nicolas_upshifts" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1218854..1220053 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044; Product type c: carrier" /codon_start=1 /transl_table=11 /product="flavohemoglobin" /protein_id="NP_389187.1" /db_xref="EnsemblGenomes-Gn:BSU13040" /db_xref="EnsemblGenomes-Tr:CAB13161" /db_xref="GOA:P49852" /db_xref="InterPro:IPR000971" /db_xref="InterPro:IPR001221" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR008333" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023950" /db_xref="SubtiList:BG11418" /db_xref="UniProtKB/Swiss-Prot:P49852" /translation="MLDNKTIEIIKSTVPVLQQHGETITGRFYDRMFQDHPELLNIFN QTNQKKKTQRTALANAVIAAAANIDQLGNIIPVVKQIGHKHRSIGIKPEHYPIVGKYL LIAIKDVLGDAATPDIMQAWEKAYGVIADAFIGIEKDMYEQAEEQAGGWKEYKPFVIA KKERESKEITSFYLKPEDSKPLPEFQAGQYISIKVRIPDSEYTHIRQYSLSDMPGKDY YRISVKKDGVVSSYLHDGLQEGDSIEISAPAGDFVLDHASQKDLVLISAGVGITPMIS MLKTSVSKQPERQILFIHAAKNSEYHALRHEVEEAAKHSAVKTAFVYREPTEEDRAGD LHFHEGQIDQQFLKELIANTDADYYICGSPSFITAMHKLVSELGSAPESIHYELFGPQ LSLAQSV*" /label="hmpA CDS" gene 1218854..1220053 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /label="hmpA gene" downshifts 1220042 /Source="Nicolas_upshifts" /id="D711" /incds=0 /nref=10 /ntot=59 /MaxReadThrough="6.06442" /MaxDrop="4.19301" /score="11.2868967" /energy="-9.3" /TU="U1053" /idTUdmin="U1051" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1220087..1220458 /Source="Nicolas_S_feature" /locus_tag="new_1374025_1374396" /HighExp="nit, B36, B60, Etha, BI, M40t90, LBGtran, M0t90, BT, S6" /AntisenseName="ykzH" /AntisenseCor="7.6554747052539299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigGF" /TUlongPSig="0.998" /label="S467" CDS complement(1220130..1220354) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389188.1" /db_xref="EnsemblGenomes-Gn:BSU13050" /db_xref="EnsemblGenomes-Tr:CAB13162" /db_xref="SubtiList:BG13336" /db_xref="UniProtKB/Swiss-Prot:O31653" /translation="MKNQKSNTLWPFDLPLAPQPEGYQQQTIDRLAGLELRMKQLIRA IEVNNELLRTMQEQQNRVCTNGSGSVIVRM*" /label="ykzH CDS" gene complement(1220130..1220354) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /label="ykzH gene" promotor_-35 1220434..1220440 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1220454..1220465 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1220460 /Source="Nicolas_upshifts" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1220499..1221230 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389189.1" /db_xref="EnsemblGenomes-Gn:BSU13060" /db_xref="EnsemblGenomes-Tr:CAB13163" /db_xref="GOA:P49853" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG11419" /db_xref="UniProtKB/Swiss-Prot:P49853" /translation="MLWMVWVFLLKPVIVFSIAYILFRLAGKKAVSQMNNFDLLLTFA IGTIISEPILTSKLPMSIYYAGAFLVLYLIMSKLSLSNKWRWLLVVSPTVLIRNGDID ERGLRKERLTVNELLGKLREKGYADPADIDLAIIEETGEVSVIPKEEARAVQVRDLNM EAERNFIPIPLILDGEILDHNLKYLQKNRSWLFEKLEEKGYSPKLLSSIILGTMNARG DISLDLNTANEPQHDPYLYKPGNNN*" /label="ykjA CDS" gene 1220499..1221230 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /label="ykjA gene" downshifts 1221208 /Source="Nicolas_upshifts" /id="D712" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="2.84532" /MaxDrop="4.44655" /score="17.2468985" /energy="-7.2" /TU="U1053" /idTUdmin="U1054" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1221269..1221277 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1221288..1221306 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1221296 /Source="Nicolas_upshifts" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1221322..1221849 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389190.1" /db_xref="EnsemblGenomes-Gn:BSU13070" /db_xref="EnsemblGenomes-Tr:CAB13164" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG11420" /db_xref="UniProtKB/Swiss-Prot:P49854" /translation="MKDLSIRNDMAPTVSLLYSAVEENSLRLASIVSHMTHSELYYKG RCQTKNSTAQLLHHITNVDIRWVWRIKENRIPDHIEQAYGPMTDESGRLPEPVNQPDL DELLKRHQHVVEKLKSVCFTLTENALNQPLSFEGDTATIRWGIWHMADHNRYHQAHIE ALKKEWKQDVAKYER*" /label="ykkA CDS" gene 1221322..1221849 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /label="ykkA gene" CDS 1221839..1222357 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389191.1" /db_xref="EnsemblGenomes-Gn:BSU13080" /db_xref="EnsemblGenomes-Tr:CAB13165" /db_xref="GOA:P49855" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11421" /db_xref="UniProtKB/Swiss-Prot:P49855" /translation="MNAKTKLVTDRIRLRCMEDRDQATLFGLLFNDPDVMTYYSGLKD KRQTREWVNWNQRNEKGYGVSLWIAEDKRTGEFLGQCGIVPQQIENQTVMEIGYMFAR RHWGNGYAQEAARACLDYGFNERQFGKMAALIDPGNKASIRVAEKIGMHYSKTIRKWN KPIAVYERKSYN*" /label="ykkB CDS" gene 1221839..1222357 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /label="ykkB gene" promotor_-35 1222351..1222358 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-35" promotor_-10 1222372..1222391 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-10" upshifts 1222375 /Source="Nicolas_upshifts" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="upshifts" misc_RNA 1222390..1222501 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /product="guanidine-sensing riboswitch (binds free guanidinium)" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17908319, 21317561, 27989440, 28001368, 28017522, 28107646, 28212758; Product type n: RNA" /label="gdwA RNA" gene 1222390..1222501 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /label="gdwA gene" downshifts 1222464 /Source="Nicolas_upshifts" /id="D713" /incds=0 /nref=205 /ntot=246 /MaxReadThrough="3.70824" /MaxDrop="6.58389" /score="30.3456563" /energy="-18.5" /TU="U1056" /idTUdmin="U1056" /TUdmin="-789" /isTUend="FALSE" /label="downshifts" CDS 1222579..1222917 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389192.1" /db_xref="EnsemblGenomes-Gn:BSU13090" /db_xref="EnsemblGenomes-Tr:CAB13166" /db_xref="GOA:P49856" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11422" /db_xref="UniProtKB/Swiss-Prot:P49856" /translation="MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLM KATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVGWPKLLLIGVLLIGVIGLKLVTQ DETEEKGGEA*" /label="gdnC CDS" gene 1222579..1222917 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /label="gdnC gene" CDS 1222917..1223234 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389193.1" /db_xref="EnsemblGenomes-Gn:BSU13100" /db_xref="EnsemblGenomes-Tr:CAB13167" /db_xref="GOA:P49857" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11423" /db_xref="UniProtKB/Swiss-Prot:P49857" /translation="MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASF SLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLK ILS*" /label="gdnD CDS" gene 1222917..1223234 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /label="gdnD gene" promotor_-35 1223234..1223237 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1223253..1223272 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1223265 /Source="Nicolas_upshifts" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1223305..1224207 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /EC_number="3.5.1.10" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8226647, 24108189; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formyltetrahydrofolate hydrolase" /protein_id="NP_389194.2" /db_xref="EnsemblGenomes-Gn:BSU13110" /db_xref="EnsemblGenomes-Tr:CAB13168" /db_xref="GOA:O34990" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004810" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG13237" /db_xref="UniProtKB/Swiss-Prot:O34990" /translation="MKSYMTQRLDEYRDGNEDKGRLLVSCPDQPGIVSAVSAFLFEHG ANIIESNQYTTDPEGGRFFLRIEFDCAGIREKKSSLQAAFASVAEKFDMTWSLTLASE LKRVAIFVSKELHCLHELIWEWQTGNLMAEIAVVISNHEEARELVERLNIPFHYMKAN KDIRAEVEKKQLELLEQYDVDVIVLARYMQILTPDFVSAHPNRIINIHHSFLPAFIGA NPYKRAYERGVKLIGATSHYVTNDLDEGPIIEQDIERVDHRDNAEALKNIGRTIERSV LARAVKWHLEDRVIVHENKTIVFN*" /label="purU CDS" gene 1223305..1224207 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /label="purU gene" downshifts 1224198 /Source="Nicolas_upshifts" /id="D714" /incds=0 /nref=91 /ntot=226 /MaxReadThrough="3.55628" /MaxDrop="5.02155" /score="16.8011006" /energy="-13.1" /TU="U1057" /idTUdmin="U1056" /TUdmin=945 /isTUend="FALSE" /label="downshifts" promotor_-35 1224254..1224260 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1224266 /Source="Nicolas_upshifts" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1224274..1224293 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1224295..1224505 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /product="T-box riboswitch specific of proline tRNA" /experiment="publication(s) with functional evidences, PMID:11917026, 12749771, 19932103, 21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11917026, 12749771, 19932103, 21233158; Product type n: RNA" /function="16.3: Control" /label="pswB RNA" gene 1224295..1224505 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /label="pswB gene" downshifts 1224463 /Source="Nicolas_upshifts" /id="D715" /incds=0 /nref=4 /ntot=52 /MaxReadThrough="6.91996" /MaxDrop="3.8361" /score="29.5878921" /energy="-17.6" /TU="U1057,U1058" /idTUdmin="U1056" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1224558..1225655 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /EC_number="2.7.2.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21233158, 21784929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21233158, 21784929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389195.2" /db_xref="EnsemblGenomes-Gn:BSU13120" /db_xref="EnsemblGenomes-Tr:CAB13169" /db_xref="GOA:P39820" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10963" /db_xref="UniProtKB/Swiss-Prot:P39820" /translation="MKKQRIVVKIGSSSLTNSKGSIDEAKIREHVQAISVLKKAGHEM ILITSGAVAAGFSSLGYPSRPVTIKGKQAAAAVGQTLLMQQYMNQFKQYSLTPGQILL TRNDFSKRERYRNAYATIMELLERGVIPIINENDSTSVEELTFGDNDMLSALVSGLIH ADQLMILTDINGLYDANPNENPEAKRFDYLPEITPELLGYAGSAGSKVGTGGMKSKLL ATQTALSLGVKVFIGTGSGEQKLADILDGRGDGTYIGDKELSSVNNTRQWIQFHSPIS GEIIIDAGAEEAMIHNGSSLLPAGVVGVNGSFPKGAVVEVRGPGGVIGKGQTHYSSEE IMEAKGKRSDELDFEKTFEVIHRNDWVNVKD*" /label="proB CDS" gene 1224558..1225655 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /label="proB gene" promotor_-35 1224745..1224747 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1224749..1224753 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1224749 /Source="Nicolas_upshifts" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1225667..1226914 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /EC_number="1.2.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21784929, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21784929, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-glutamyl phosphate reductase" /protein_id="NP_389196.2" /db_xref="EnsemblGenomes-Gn:BSU13130" /db_xref="EnsemblGenomes-Tr:CAB13170" /db_xref="GOA:P39821" /db_xref="InterPro:IPR000965" /db_xref="InterPro:IPR012134" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR020593" /db_xref="SubtiList:BG10964" /db_xref="UniProtKB/Swiss-Prot:P39821" /translation="MSEVSVKAKLAKEAAAEMIMKTTAEKDEALSLIANGLRKELDFL LAENAKDIVNGKENGLTPDIIDRLSLDEKRIRDIADAVELLIDLADPIGDSLETIEKE NGLFIEKIRVPLGVVGMIYEARPNVTVDAATLCLKTGNAVVLRGSSSAIHSNKALVSV IYRALEQSALPIHAVQLIEDTSRETAKELFTLNDGLDVLIPRGGKKLIDLVVRESTVP VLETGAGNCHIFIDETAKPQMAEKVVVNAKTQRPSVCNAIESLLIHKAWARQHGKELL DQLENAGVEIRGDELVCELHPSSKQASKEDWETEFLAPVLSVKTVENVQEAVKHIQQY GTNHSEAILTENDKNAVYFQTAVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHAR GPMGLPALTSTKYIIKGTGQIRE*" /label="proA CDS" gene 1225667..1226914 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /label="proA gene" downshifts 1226905 /Source="Nicolas_upshifts" /id="D716" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="4.1607" /MaxDrop="6.017" /score="11.118012" /energy="-11" /TU="U1058" /idTUdmin="U1059" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1226976..1226983 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1226998..1227017 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1227007 /Source="Nicolas_upshifts" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1227040..1227465 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11418552, 17502599, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418552, 17502599, 21749987, 24184231; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin" /protein_id="NP_389197.1" /db_xref="EnsemblGenomes-Gn:BSU13140" /db_xref="EnsemblGenomes-Tr:CAB13171" /db_xref="GOA:O34762" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13238" /db_xref="UniProtKB/Swiss-Prot:O34762" /translation="MSQPLFTATVSAVGGREGKVISSDRVLELDVAMPGTPRAKKLEK ATNPEQLFAAGYAACFDSALQLVARTERVKVETEVTANVSLLKDEADQGYKLGVTLQV KGEGVSASELEALVKKAHGVCPYSKATSGNIDVTLEVAE*" /label="ohrA CDS" gene 1227040..1227465 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /label="ohrA gene" downshifts 1227454 /Source="Nicolas_upshifts" /id="D717" /incds=0 /nref=57 /ntot=174 /MaxReadThrough="0.0429100000000009" /MaxDrop="3.90314" /score="30.9245751" /energy="-16.6" /TU="NA" /idTUdmin="U1060" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1227496..1227939) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11983871, 17502599, 18363800, 20094649, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11983871, 17502599, 18363800, 20094649, 21749987, 24184231; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator sensing organic peroxides" /protein_id="NP_389198.1" /db_xref="EnsemblGenomes-Gn:BSU13150" /db_xref="EnsemblGenomes-Tr:CAB13172" /db_xref="GOA:O34777" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1Z91" /db_xref="PDB:1Z9C" /db_xref="SubtiList:BG13239" /db_xref="UniProtKB/Swiss-Prot:O34777" /translation="MENKFDHMKLENQLCFLLYASSREMTKQYKPLLDKLNITYPQYL ALLLLWEHETLTVKKMGEQLYLDSGTLTPMLKRMEQQGLITRKRSEEDERSVLISLTE DGALLKEKAVDIPGTILGLSKQSGEDLKQLKSALYTLLETLHQKN*" /label="ohrR CDS" gene complement(1227496..1227939) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /label="ohrR gene" downshifts complement(1227530) /Source="Nicolas_upshifts" /id="D718" /incds=0 /nref=105 /ntot=232 /MaxReadThrough="-0.17111" /MaxDrop="4.73026" /score="34.7008532" /energy="-16.6" /TU="NA" /idTUdmin="U1061" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1227966..1227985) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1227972) /Source="Nicolas_upshifts" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1228000..1228003) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1228021..1228027 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1228041..1228059 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1228047 /Source="Nicolas_upshifts" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="upshifts" CDS 1228082..1228492 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9696771, 11418552, 18084074" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696771, 11418552, 18084074; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="organic hydroperoxide resistance reductase B" /protein_id="NP_389199.1" /db_xref="EnsemblGenomes-Gn:BSU13160" /db_xref="EnsemblGenomes-Tr:CAB13173" /db_xref="GOA:P80242" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="PDB:2BJO" /db_xref="SubtiList:BG19021" /db_xref="UniProtKB/Swiss-Prot:P80242" /translation="MALFTAKVTARGGRAGHITSDDGVLDFDIVMPNAKKEGQTGTNP EQLFAAGYAACFGGALEHVAKEQNIEIDSEIEGQVSLMKDESDGGFKIGVTLVVNTKD LDREKAQELVNAAHEFCPYSKATRGNVDVKLELK*" /label="ohrB CDS" gene 1228082..1228492 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /label="ohrB gene" downshifts 1228470 /Source="Nicolas_upshifts" /id="D719" /incds=0 /nref=7 /ntot=145 /MaxReadThrough="8.17185" /MaxDrop="4.0663" /score="17.6512157" /energy="-12.1" /TU="U1062" /idTUdmin="U1062" /TUdmin="-855" /isTUend="FALSE" /label="downshifts" CDS 1228519..1228689 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097717.1" /db_xref="EnsemblGenomes-Gn:BSU13169" /db_xref="EnsemblGenomes-Tr:CAX52607" /db_xref="UniProtKB/Swiss-Prot:C0H400" /translation="MFFGVGHAGRAQIYDKTSEKRLKHAFKPKVTDEAGGWHGVCRAE LRVYAVLYLHRA*" /label="ykzN CDS" gene 1228519..1228689 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /label="ykzN gene" S_feature 1228690..1229367 /Source="Nicolas_S_feature" /locus_tag="new_1382628_1383305" /HighExp="Etha, Salt, M9-stat, Sw, B60, LPhT, B36, Heat, Gly, BC" /AntisenseName="guaD" /AntisenseCor="-5.7732597431508298E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S468" CDS complement(1228739..1229209) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /EC_number="3.5.4.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11101664, 15180998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101664, 15180998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanine deaminase" /protein_id="NP_389200.1" /db_xref="EnsemblGenomes-Gn:BSU13170" /db_xref="EnsemblGenomes-Tr:CAB13174" /db_xref="GOA:O34598" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1TIY" /db_xref="PDB:1WKQ" /db_xref="SubtiList:BG13240" /db_xref="UniProtKB/Swiss-Prot:O34598" /translation="MNHETFLKRAVTLACEGVNAGIGGPFGAVIVKDGAIIAEGQNNV TTSNDPTAHAEVTAIRKACKVLGAYQLDDCILYTSCEPCPMCLGAIYWARPKAVFYAA EHTDAAEAGFDDSFIYKEIDKPAEERTIPFYQVTLTEHLSPFQAWRNFANKKEY*" /label="guaN CDS" gene complement(1228739..1229209) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /label="guaN gene" downshifts complement(1228763) /Source="Nicolas_upshifts" /id="D720" /incds=0 /nref=25 /ntot=112 /MaxReadThrough="0.698199999999999" /MaxDrop="4.30578" /score="-6.41557266" /energy="-13.5" /TU="NA" /idTUdmin="U1063" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1229231..1229250) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1229247) /Source="Nicolas_upshifts" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1229249..1229356) /Source="Nicolas_S_feature" /locus_tag="new_1383187_1383294_c" /HighExp="BMM, MG 10, MG 15, MG 5, MG t5, GM 25, B36, Gly, B60, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.044, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S469" promotor_-35 complement(1229266..1229269) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1229325 /Source="Nicolas_upshifts" /id="D721" /incds=0 /nref=9 /ntot=34 /MaxReadThrough="0.95942" /MaxDrop="5.95076" /score="15.2916843" /energy="-11.5" /TU="NA" /idTUdmin="U1062" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1229382..1231670) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /EC_number="2.1.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cobalamin-independent methionine synthase" /protein_id="NP_389201.2" /db_xref="EnsemblGenomes-Gn:BSU13180" /db_xref="EnsemblGenomes-Tr:CAB13175" /db_xref="GOA:P80877" /db_xref="InterPro:IPR002629" /db_xref="InterPro:IPR006276" /db_xref="InterPro:IPR013215" /db_xref="SubtiList:BG12616" /db_xref="UniProtKB/Swiss-Prot:P80877" /translation="MTTIKTSNLGFPRIGLNREWKKALEAYWKGSTDKDTFLKQIDEL FLSAVKTQIDQQIDVVPVSDFTQYDHVLDTAVSFNWIPKRFRHLTDATDTYFAIARGI KDAVSSEMTKWFNTNYHYIVPEYDESIEFRLTRNKQLEDYRRIKQEYGVETKPVIVGP YTFVTLAKGYEPSEAKAIQKRLVPLYVQLLKELEEEGVKWVQIDEPALVTASSEDVRG AKELFESITSELSSLNVLLQTYFDSVDAYEELISYPVQGIGLDFVHDKGRNLEQLKTH GFPTDKVLAAGVIDGRNIWKADLEERLDAVLDILSIAKVDELWIQPSSSLLHVPVAKH PDEHLEKDLLNGLSYAKEKLAELTALKEGLVSGKAAISEEIQQAKADIQALKQFATGA NSEQKKELEQLTDKDFKRPIPFEERLALQNESLGLPLLPTTTIGSFPQSAEVRSARQK WRKAEWSDEQYQNFINAETKRWIDIQEELELDVLVHGEFERTDMVEYFGEKLAGFAFT KYAWVQSYGSRCVRPPVIYGDVEFIEPMTVKDTVYAQSLTSKHVKGMLTGPVTILNWS FPRNDISRKEIAFQIGLALRKEVKALEDAGIQIIQVDEPALREGLPLKTRDWDEYLTW AAEAFRLTTSSVKNETQIHTHMCYSNFEDIVDTINDLDADVITIEHSRSHGGFLDYLK NHPYLKGLGLGVYDIHSPRVPSTEEMYNIIVDALAVCPTDRFWVNPDCGLKTRQQEET VAALKNMVEAAKQARAQQTQLV*" /label="metE CDS" gene complement(1229382..1231670) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /label="metE gene" downshifts complement(1229401) /Source="Nicolas_upshifts" /id="D722" /incds=0 /nref=212 /ntot=239 /MaxReadThrough="5.25958" /MaxDrop="7.50935" /score="29.3354648" /energy="-11.5" /TU="U1064,U1065" /idTUdmin="U1063" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature complement(1231671..1231733) /Source="Nicolas_S_feature" /locus_tag="new_1385609_1385671_c" /HighExp="MG 15, MG 5, MG t5, BMM, T-1.40H, MG 25, MG 10, GM 25, Mal, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.044, 1, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S470" promotor_no_box complement(1231693..1231793) /Source="Nicolas_upshift_promotors" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1231733) /Source="Nicolas_upshifts" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1231798..1231953) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762, 22543867" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762, 22543867; Product type n : RNA" /function="16.3: Control" /label="mswB RNA" gene complement(1231798..1231953) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /label="mswB gene" downshifts complement(1231799) /Source="Nicolas_upshifts" /id="D723" /incds=0 /nref=55 /ntot=106 /MaxReadThrough="8.12248" /MaxDrop="6.4813" /score="24.0596293" /energy="-16.2" /TU="U1065,U1066" /idTUdmin="U1066" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1231986..1232005) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1231998) /Source="Nicolas_upshifts" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1232000..1232085) /Source="Nicolas_S_feature" /locus_tag="new_1385938_1386023_c" /HighExp="BT, BC, B36, M9-stat, T5.0H, S3, S6, T4.0H, S5, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S471" promotor_-35 complement(1232021..1232028) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1232086..1233045) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3087947, 14680823, 23569278" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3087947, 14680823, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="intracellular serine protease" /protein_id="NP_389202.1" /db_xref="EnsemblGenomes-Gn:BSU13190" /db_xref="EnsemblGenomes-Tr:CAB13176" /db_xref="GOA:P11018" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG10674" /db_xref="UniProtKB/Swiss-Prot:P11018" /translation="MNGEIRLIPYVTNEQIMDVNELPEGIKVIKAPEMWAKGVKGKNI KVAVLDTGCDTSHPDLKNQIIGGKNFTDDDGGKEDAISDYNGHGTHVAGTIAANDSNG GIAGVAPEASLLIVKVLGGENGSGQYEWIINGINYAVEQKVDIISMSLGGPSDVPELK EAVKNAVKNGVLVVCAAGNEGDGDERTEELSYPAAYNEVIAVGSVSVARELSEFSNAN KEIDLVAPGENILSTLPNKKYGKLTGTSMAAPHVSGALALIKSYEEESFQRKLSESEV FAQLIRRTLPLDIAKTLAGNGFLYLTAPDELAEKAEQSHLLTL*" /label="ispA CDS" gene complement(1232086..1233045) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /label="ispA gene" S_feature complement(1233046..1233097) /Source="Nicolas_S_feature" /locus_tag="new_1386984_1387035_c" /HighExp="BT, B36, BC, T5.0H, M9-stat, T0.30H, T3.30H, T3.0H, T4.0H, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S472" promotor_-10 complement(1233090..1233109) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1233102) /Source="Nicolas_upshifts" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1233123..1233129) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1233214..1233217 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1233230 /Source="Nicolas_upshifts" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1233233..1233252 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1233268..1234101 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_389203.1" /db_xref="EnsemblGenomes-Gn:BSU13200" /db_xref="EnsemblGenomes-Tr:CAB13177" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12609" /db_xref="UniProtKB/Swiss-Prot:O34860" /translation="MKLNEKLYAFFSEHVEQMAEEWIETMEESDPNSLYALHNATVTE ELKEQDREFYRHLNYMYVLPEKQFLEEFQEWVIELTNDQKHLDTPVQYVIREFMRNRR LYTKYFEKFAEENESAFEPGEKQKWADLIVKVFDFTIYTFVDHAEMNAKQQLNAQREM ILELSSPVITLSKSTALLPLVGDIDTERAKFILENTLQACAKRRVEHLLIDLSGVVVV DTMVAHQIFKLIEALNLIGVRSTLSGIRPEIAQTAVQLGIDFSNITIKTNLAQALNYH Q*" /label="rsbRB CDS" gene 1233268..1234101 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /label="rsbRB gene" downshifts 1234077 /Source="Nicolas_upshifts" /id="D724" /incds=0 /nref=219 /ntot=254 /MaxReadThrough="3.01586" /MaxDrop="6.07238" /score="22.2655638" /energy="-12.1" /TU="NA" /idTUdmin="U1067" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1234132..1234896) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, transmembrane T component" /protein_id="NP_389204.1" /db_xref="EnsemblGenomes-Gn:BSU13210" /db_xref="EnsemblGenomes-Tr:CAB13178" /db_xref="GOA:O34572" /db_xref="InterPro:IPR003339" /db_xref="SubtiList:BG13248" /db_xref="UniProtKB/Swiss-Prot:O34572" /translation="MKQPLHLINPTVKAAAVFCCVVMLSFIYNPYTPACFYIIIVAGV LLAAGIPLKKWLLFTIPFLILAFGCVWTAAVFGKVPTTPDNFLFQAGPISINSDNVSV GISLGFRILCFSALSMMFVFTTDPILFMLSLVQQCRLSPKLAYGVIAGFRFLPLLKDE VQLIQQAHKIRGGAAESGIINKISALKRYTIPLLASAIRKAERTALAMESKGFTGSRN RTYYRTLSVNRRDWVFFCLVLLLFAGSFLVSLCFAS*" /label="thiX CDS" gene complement(1234132..1234896) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /label="thiX gene" downshifts complement(1234153) /Source="Nicolas_upshifts" /id="D725" /incds=0 /nref=143 /ntot=164 /MaxReadThrough="0.824010000000001" /MaxDrop="6.67697" /score="34.7739353" /energy="-12.1" /TU="NA" /idTUdmin="U1069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1234871..1236514) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine ABC transporter (ATP-binding subunit)" /protein_id="NP_389205.2" /db_xref="EnsemblGenomes-Gn:BSU13220" /db_xref="EnsemblGenomes-Tr:CAB13179" /db_xref="GOA:O34362" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13249" /db_xref="UniProtKB/Swiss-Prot:O34362" /translation="MQAFDELLTVEQLSFSYEEDEKPVFQDISFELQKGECVLLLGPS GCGKSSLALCLNGLYPEACDGIQSGHVFLFQKPVTDAETSETITQHAGVVFQDPDQQF CMLTVEDEIAFGLENLQIPKEEMTEKINAVLEKLRITHLKEKMISTLSGGQKQKVALA CILAMEPELIILDEPTSLLDPFSAREFVHLMKDLQREKGFSLLVIEHQLDEWAPWIER TIVLDKSGKKALDGLTKNLFQHEAETLKKLGIAIPKVCHLQEKLSMPFTLSKEMLFKE PIPAGHVKKKKAPSGESVLEVSSLSFARGQQAIFKDISFSLREGSLTALVGPNGTGKS TLLSVLASLMKPQSGKILLYDQPLQKYKEKELRKRMGFVFQNPEHQFVTDTVYDELLF GQKANAETEKKAQHLLQRFGLAHLADHHPFAISQGQKRRLSVATMLMHDVKVLLLDEP TFGQDARTAAECMEMIQRIKAEGTAVLMITHDMELVSSYADSVLVLHDTGLAFDGSPA QLFSQETGLVQKAKLTLPLLYEWMAFQEEVRDEATVTSH*" /label="thiW CDS" gene complement(1234871..1236514) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /label="thiW gene" CDS complement(1236501..1237100) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 27447050, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 27447050, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, permease component" /protein_id="NP_389206.2" /db_xref="EnsemblGenomes-Gn:BSU13230" /db_xref="EnsemblGenomes-Tr:CAB13180" /db_xref="GOA:O34738" /db_xref="InterPro:IPR017195" /db_xref="PDB:5EDL" /db_xref="SubtiList:BG13250" /db_xref="UniProtKB/Swiss-Prot:O34738" /translation="MKSWKVKEIVIMSVISIVFAVVYLLFTHFGNVLAGMFGPIAYEP IYGIWFIVSVIAAYMIRKPGAALVSEIIAALVECLLGNPSGPMVIVIGIVQGLGAEAV FLATRWKAYSLPVLMLAGMGSSVASFIYDLFVSGYAAYSPGYLLIMLVIRLISGALLA GLLGKAVSDSLAYTGVLNGMALGKELKKKRKRASEHASL*" /label="thiV CDS" gene complement(1236501..1237100) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /label="thiV gene" CDS complement(1237102..1237704) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15451668, 16291685, 16356850, 20471400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15451668, 16291685, 16356850, 20471400; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiamine-binding protein (oxidation stress protein)" /protein_id="NP_389207.1" /db_xref="EnsemblGenomes-Gn:BSU13240" /db_xref="EnsemblGenomes-Tr:CAB13181" /db_xref="GOA:O34911" /db_xref="InterPro:IPR011522" /db_xref="InterPro:IPR015835" /db_xref="InterPro:IPR029756" /db_xref="PDB:1S7H" /db_xref="PDB:1S99" /db_xref="PDB:1SBR" /db_xref="SubtiList:BG13251" /db_xref="UniProtKB/Swiss-Prot:O34911" /translation="MEHICGTSRIAGFRFSLYPMTDDFISVIKSALKKTDTSKVWTKT DHISTVLRGSIDHVFDAAKAIYLHAANSEQHIVMNGTFSIGCPGDTQGDTYLSKGDKR VNEDAVRGLKAEAPCQFALYPMNEPDYMGLIMEAVDIAKAQGTFVQGVHYASELDGDA HDVFSTLEAVFRMAEQQTNHITMTVNLSANSPSRKNRKQG*" /label="thiU CDS" gene complement(1237102..1237704) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /label="thiU gene" downshifts complement(1237782) /Source="Nicolas_upshifts" /id="D726" /incds=0 /nref=28 /ntot=88 /MaxReadThrough="7.47395" /MaxDrop="5.73297" /score="19.7469386" /energy="-10.9" /TU="U1069" /idTUdmin="U1069" /TUdmin="-3629" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1237801..1237913) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /product="thiamine pyrophosphate riboswitch" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswB RNA" gene complement(1237801..1237913) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /label="tswB gene" promotor_-35 1237914..1237917 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1237928..1237947) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1237933..1237952 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1237944 /Source="Nicolas_upshifts" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1237949) /Source="Nicolas_upshifts" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1237962..1237969) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1238015..1238701 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YkoH]" /protein_id="NP_389208.1" /db_xref="EnsemblGenomes-Gn:BSU13250" /db_xref="EnsemblGenomes-Tr:CAB13182" /db_xref="GOA:O34903" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13252" /db_xref="UniProtKB/Swiss-Prot:O34903" /translation="MEKGHILIVEDEEKIARVLQLELEYEGYSVTIKHNGTEGLDAAA EGGYSLVLLDVMLPGLSGLEVLRRLRKTDSQTPVILLTARDSIPDKVTGLDIGANDYV TKPFEIEELLARIRAALRQNGTKTEDIGTFLTYDDLRVNEKTREVRRGDKEVELTPRE FDLLVYMLKHPQQVLTREQILSSVWGFDYIGDTNVVDVYIRYIRKKLDYPYEKQLIHT IRGVGYAIKG*" /label="ykoG CDS" gene 1238015..1238701 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /label="ykoG gene" CDS 1238705..1240069 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YkoG]" /protein_id="NP_389209.1" /db_xref="EnsemblGenomes-Gn:BSU13260" /db_xref="EnsemblGenomes-Tr:CAB13183" /db_xref="GOA:O34638" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13253" /db_xref="UniProtKB/Swiss-Prot:O34638" /translation="MKLKTKIHLYTSISLLILLILVHTAVYLIFSSALTSKDAARLAD ETDNIAEALRAAETEGVALQDMLQAYLPANGMVRVVNGDQKAVMTITKEKAYKDFPLS FHSGETADVRKPDGKLFAEAAVPVIWTDGQVVSLQLVERLENTEESLFLLKIILIAAS AAVCIASFFAGSLLARRIINPIRRLMITMKDIQRDKEFKTISLEGQSNDELYQMGLTF NEMAMMLKEHYDKQQQFVQDASHELKTPLTIIESYSSLMKRWGAKKPEVLEESIEAIH SEAVHMKKLTNQLLALAKSHQGLEVDLKTIDLIKAARAVMQTLQSVYQRDILLETDKE SLLVKADEERIKQLLTILLDNAIKYSEKPIEMSAGTRNGRPFLSVRDEGIGIPEEHIP HLFERFYRADEARNRKTGGTGLGLSIAKQIADEHGIELSVKSKPGQGTAVTMQFSEQN GGGR*" /label="ykoH CDS" gene 1238705..1240069 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /label="ykoH gene" CDS 1240066..1240746 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295; Product type m : membranecomponent" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389210.1" /db_xref="EnsemblGenomes-Gn:BSU13270" /db_xref="EnsemblGenomes-Tr:CAB13184" /db_xref="GOA:O34551" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13254" /db_xref="UniProtKB/Swiss-Prot:O34551" /translation="MTKTIKTVSFAAAAILVVIICTFLIIRQTHENVLSKETVVKKVE ASYEGKVTKATQSKDKKTYDITLENPKGTYFVKADAISADILSMNRVKAVNPSAMTEK EAEHLALERVPGTVKKQTRQSQVATYTIQKEDGKTYEVKVDMQAKTVLSADQISSKDQ QKTPITKKEAKTIAERKTGGTADDADLEESEGTLIFEVDVDLPDNKEATVKINAYTGK VANIVYED*" /label="ykoI CDS" gene 1240066..1240746 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /label="ykoI gene" promotor_-35 1240775..1240780 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1240796..1240814 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1240799 /Source="Nicolas_upshifts" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1240838..1241350 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17209068; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389211.1" /db_xref="EnsemblGenomes-Gn:BSU13280" /db_xref="EnsemblGenomes-Tr:CAB13185" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13255" /db_xref="UniProtKB/Swiss-Prot:O35012" /translation="MLKKKWMVGLLAGCLAAGGFSYNAFATENNENRQASSKTDALTE QEAEAIAKTVVDGTVEDIDRDLYNGKEVYEVEIEKEGEDYDVYVDIHTKQALNDPLKE KAEQVAITKEEAEEIALKQTGGTVTESKLDEDDGAYIYEMEIQTKQGTETEFEISAKD GRIIKQEIDD*" /label="ykoJ CDS" gene 1240838..1241350 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /label="ykoJ gene" downshifts 1241336 /Source="Nicolas_upshifts" /id="D727" /incds=0 /nref=52 /ntot=228 /MaxReadThrough="3.74302" /MaxDrop="6.03059" /score="28.1760649" /energy="-13.7" /TU="U1070" /idTUdmin="U1070" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 1241381..1241387 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1241401..1241412 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1241402 /Source="Nicolas_upshifts" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1241433..1241570 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389212.1" /db_xref="EnsemblGenomes-Gn:BSU13290" /db_xref="EnsemblGenomes-Tr:CAB13186" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG13332" /db_xref="UniProtKB/Swiss-Prot:O34405" /translation="MEKKEEQYINQAEYVPHPTKEGEYALFLHETYHLLSEDDETQTT E*" /label="ykzD CDS" gene 1241433..1241570 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /label="ykzD gene" downshifts 1241543 /Source="Nicolas_upshifts" /id="D728" /incds=0 /nref=7 /ntot=31 /MaxReadThrough="1.81189" /MaxDrop="3.56977" /score="-4.52149284" /energy="-5.9" /TU="NA" /idTUdmin="U1070" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 1241629..1241636 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1241650..1241669 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1241652..1241971 /Source="Nicolas_S_feature" /locus_tag="new_1395590_1395909" /HighExp="LBGstat, LBGtran, M40t45, MG 25, Mt0, Salt, MG 45, LPhT, BMM, MG t5" /AntisenseName="ykzO" /AntisenseCor="-0.16301119751811899" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S473" upshifts 1241652 /Source="Nicolas_upshifts" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1241684..1241837 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /product="magnesium riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 17803910, 21315082, 28455443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 17803910, 21315082, 28455443; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="swmG RNA" gene 1241684..1241837 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /label="swmG gene" promotor_-35 1241949..1241958 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1241971..1241990 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1241973..1242074 /Source="Nicolas_S_feature" /locus_tag="new_1395911_1396012" /HighExp="LBGstat, LBGtran, M40t45, Mt0, LPhT, Paraq, MG t5, MG 25, MG 60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99773400000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.876, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S474" upshifts 1241973 /Source="Nicolas_upshifts" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" CDS 1242075..1243430 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 22970223, 24415722, 24968120, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 22970223, 24415722, 24968120, 25182490; Product type t : transporter" /codon_start=1 /transl_table=11 /product="magnesium transporter" /protein_id="NP_389213.1" /db_xref="EnsemblGenomes-Gn:BSU13300" /db_xref="EnsemblGenomes-Tr:CAB13187" /db_xref="GOA:O34442" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006667" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR006669" /db_xref="InterPro:IPR036739" /db_xref="SubtiList:BG13256" /db_xref="UniProtKB/Swiss-Prot:O34442" /translation="MVQNMTYDELILRIIILLRDGKIRDFRSVIDELQPYDMAFIFKE MPEKHRARYLSYLTVDDITDMIGELEREFQLVVLNKVGKTKATLAMNKMDNDDLAQLL EEMDEELKEQLLSSMEASESKAVQLLMNYPADSAGRMMTNRYVWIPQHYTVKDAVVKL KSFAEIAESINYLYVINESKQLVGVLSYRDLILGEPEEKVQDLMFTRVISADALQDQE EVARLIERYDFLAIPVVEENNVLVGIVTVDDIIDVVIREADEDYEKFAASGKDITFDT KAYVAAYRRLPWLILLLFIGLISGSIISYFEDALKQVVALAFFMPMVSGMTGNTGTQS LAVVIRGLSKEEMNKKTIVRLIFREFRTSIFIGAVCSVLIAIVSIIWQGNALLGFVVA SSLFLTLIIGTMSGTIIPIILHKLKVDPAIASGPLITTLNDILSLLIYFGIATAFIHS L*" /label="mgtE CDS" gene 1242075..1243430 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /label="mgtE gene" downshifts 1243421 /Source="Nicolas_upshifts" /id="D729" /incds=0 /nref=160 /ntot=239 /MaxReadThrough="1.02063" /MaxDrop="7.38933" /score="-4.14569718" /energy="-8.9" /TU="NA" /idTUdmin="U1072" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1243473..1243805) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen sensing transcriptional regulator" /protein_id="NP_389214.1" /db_xref="EnsemblGenomes-Gn:BSU13310" /db_xref="EnsemblGenomes-Tr:CAB13188" /db_xref="GOA:Q45666" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG11805" /db_xref="UniProtKB/Swiss-Prot:Q45666" /translation="MTTEDHSYKDKKVISIGIVSELTGLSVRQIRYYEERKLIYPQRS SRGTRKYSFADVERLMDIANKREDGVQTAEILKDMRKKEQMLKNDPQVRKKMLEGQLN AHFRYKNR*" /label="tnrA CDS" gene complement(1243473..1243805) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /label="tnrA gene" promotor_-10 complement(1243821..1243840) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1243831) /Source="Nicolas_upshifts" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1243833..1244221) /Source="Nicolas_S_feature" /locus_tag="new_1397771_1398159_c" /HighExp="M9-stat, BC, LoTm, T1.30H, T0.30H, T2.0H, S8, C30, T4.0H, T2.30H" /AntisenseName="ykzB" /AntisenseCor="-3.3870578787867499E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.92" /TUlongSig="NA" /TUlongPSig="NA" /label="S475" promotor_-35 complement(1243856..1243861) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1243893..1243993 /Source="Nicolas_upshift_promotors" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1243953 /Source="Nicolas_upshifts" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="upshifts" CDS 1244000..1244155 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389215.1" /db_xref="EnsemblGenomes-Gn:BSU13320" /db_xref="EnsemblGenomes-Tr:CAB13189" /db_xref="SubtiList:BG13330" /db_xref="UniProtKB/Swiss-Prot:O34923" /translation="MEEEKAVSLAKEIIELDIKRDEMLETFMQLAGEQAFQLLRSVQN GQYRKSS*" /label="ykzB CDS" gene 1244000..1244155 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /label="ykzB gene" promotor_-35 1244164..1244171 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1244178..1244195 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1244195 /Source="Nicolas_upshifts" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1244206..1244225) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1244221) /Source="Nicolas_upshifts" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1244239..1244245) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1244243..1244425 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389216.1" /db_xref="EnsemblGenomes-Gn:BSU13330" /db_xref="EnsemblGenomes-Tr:CAB13190" /db_xref="SubtiList:BG13257" /db_xref="UniProtKB/Swiss-Prot:O34763" /translation="MSNLLKSALEKERRHYSEKLYQIGVYNKEVMNKMTISELRKEYA YFFRSITNHKNYPYTR*" /label="ykoL CDS" gene 1244243..1244425 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /label="ykoL gene" downshifts 1244393 /Source="Nicolas_upshifts" /id="D730" /incds=0 /nref=2 /ntot=8 /MaxReadThrough="3.83398" /MaxDrop="4.6651" /score="19.6832496" /energy="-11.2" /TU="U1076" /idTUdmin="U1075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1244450..1244458 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1244469..1244487 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1244475..1244557 /Source="Nicolas_S_feature" /locus_tag="new_1398413_1398495" /HighExp="T3.0H, M9-stat, T1.30H, T2.30H, Lbstat, T3.30H, Lbtran, S2, T4.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, Sig-" /TUshortPSig="0.996, 0.00699" /TUlongSig="NA" /TUlongPSig="NA" /label="S476" upshifts 1244475 /Source="Nicolas_upshifts" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" CDS 1244558..1245022 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_389217.1" /db_xref="EnsemblGenomes-Gn:BSU13340" /db_xref="EnsemblGenomes-Tr:CAB13191" /db_xref="GOA:O34949" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13258" /db_xref="UniProtKB/Swiss-Prot:O34949" /translation="MMRLSFNEEEVERAMNLYRVFARAFKSVSEHSIRDSKEHGFNPT EFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAH LTDKGNEYLDKIYPIHALRIARAFSGLSPDEQDQLIVLLKKAGIHSQHLLFR*" /label="ykoM CDS" gene 1244558..1245022 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /label="ykoM gene" downshifts 1245007 /Source="Nicolas_upshifts" /id="D731" /incds=0 /nref=70 /ntot=210 /MaxReadThrough="2.86787" /MaxDrop="5.38705" /score="24.8730632" /energy="-9.8" /TU="U1078" /idTUdmin="U1078" /TUdmin="-112" /isTUend="FALSE" /label="downshifts" CDS complement(1245037..1246158) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389218.2" /db_xref="EnsemblGenomes-Gn:BSU13350" /db_xref="EnsemblGenomes-Tr:CAB13192" /db_xref="GOA:C0SPB9" /db_xref="InterPro:IPR009695" /db_xref="SubtiList:BG13259" /db_xref="UniProtKB/Swiss-Prot:C0SPB9" /translation="MKNILIFPFLSISTGHHHVADALQAELESQGLAAEKIDIFSHSY RRLEKLSSVAYLKWIQYFPKTYSGIYRLLACGEFQHDKRYFMYEWLFTQQMRHILQEK QPDIAFCTHALPSYLLNRLKPEYPNLTVVNVYTDFFVNQLWGRKNIDYHFVPSTEVKK QLISEGIDQNNIYLTGIPVHQNFEMESADTLQHHPPYTIIITGGSMGVGGILKWVQEL SPGGKILYKILCGRNEKLYSYVKSLHHPLIEAIPYLHSKAEMNRLYEQATGIMTKPGG VTISECLQKRLPVFIYHALPGQEEMNLNLLHERKLVTDMRNWDMQKAEEYIAAFFQSN EQMKEYKKHVNGYLGEMSDRKIKDVLKRIIWKQKNTLLK*" /label="ykoN CDS" gene complement(1245037..1246158) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /label="ykoN gene" promotor_-35 1245446..1245454 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1245468..1245487 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1245471..1246249 /Source="Nicolas_S_feature" /locus_tag="new_1399409_1400187" /HighExp="S6, S8, S7, S5, BT, B36, S4, S3, Pyr, G/S" /AntisenseName="ykoN" /AntisenseCor="0.84084970563549499" /AntisenseRegPval="-72.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S477" upshifts 1245471 /Source="Nicolas_upshifts" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1246187..1246198) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1246207) /Source="Nicolas_upshifts" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1246213..1246219) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1246250..1246801 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389219.2" /db_xref="EnsemblGenomes-Gn:BSU13360" /db_xref="EnsemblGenomes-Tr:CAB13193" /db_xref="SubtiList:BG13260" /db_xref="UniProtKB/Swiss-Prot:O34495" /translation="MKTCFLSIWRVVDPIYFFFSRLSLIDNDQKSVFRVRLTKYKGHH VVLSDGTHIRKNDVLVKIHLHNIKLIRELQSIESAVRKGIIIYQKVYQSMPLLLDYIN NHKKSEKIKGIIGITMLDKGVERLGFDVITPVNPFYRCFKKVSHVPILYLTSKPVSLR HLPNSSYLFISKEKLQKTYQKKD*" /label="ykoP CDS" gene 1246250..1246801 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /label="ykoP gene" downshifts 1246769 /Source="Nicolas_upshifts" /id="D732" /incds=0 /nref=4 /ntot=25 /MaxReadThrough="3.31887" /MaxDrop="3.7149" /score="-2.92393792" /energy="-7" /TU="U1079" /idTUdmin="U1079" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(1246829..1247641) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metallophosphoesterase" /protein_id="NP_389220.1" /db_xref="EnsemblGenomes-Gn:BSU13370" /db_xref="EnsemblGenomes-Tr:CAB13194" /db_xref="GOA:O35040" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13261" /db_xref="UniProtKB/Swiss-Prot:O35040" /translation="MFTILLSLAILVFVPFLYKANRNTKDVKVNTISIDQKDGLPARK KLNILHLSDLHLENISVSPEELYHLTKDQPVDIIALTGDFLDRKRNIPKLAGYLNALQ KLKPAYGMYAVFGNHDYVLKEEDFQRLKRVLEENGCITLQNEHVRIETAAGPVNIIGI DDYSTNRSNITGSYQSLENGYHLVLTHDPNIILDMKDVHYDYLLSGHFHGGQIHWPKP YHLVKMGKLVRMNMIKGLHYHHDKPFYISEGLGQTGVNIRVGSRPEVTFHQI*" /label="ykoQ CDS" gene complement(1246829..1247641) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /label="ykoQ gene" promotor_-10 complement(1247601..1247620) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1247615) /Source="Nicolas_upshifts" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1247634..1247639) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1247742..1247748 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1247759..1247833 /Source="Nicolas_S_feature" /locus_tag="new_1401697_1401771" /HighExp="S5, S6, S7, S4, S8, T5.0H, ferm, nit, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S478" upshifts 1247759 /Source="Nicolas_upshifts" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1247762..1247773 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1247834..1249528 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389221.1" /db_xref="EnsemblGenomes-Gn:BSU13380" /db_xref="EnsemblGenomes-Tr:CAB13195" /db_xref="GOA:O34830" /db_xref="SubtiList:BG13262" /db_xref="UniProtKB/Swiss-Prot:O34830" /translation="MLRLMRQQKKETYYLWIALFLLLLYVSPLFILKEDAHIRVHDNL DSNIAWYKVLADSGEIVGKVDAAIPQIINGLPRDAFGTEWSGIVWLHAFFSSMTAYAI SQTVTRVVAFFGMYVLLKKHIIPEPKAAFIRIGVSLAFALTPFWPSGMLSTLGYPLAL WAFLNIRKGDISWREWLTLGLLPLYSSFVLGFFFFLAGMACFWLYDAITKRRWNLMFL GSIAFMTSIYLFVEYRLVYSMLFEHAPMHRIEFISSRHDVWHSLRLSIKNFVYGHNHV MTVHTVVILPILMVVFAALLFKRNRTKPENVYLFLCVLNYGLSLWYAFWFNKIWAVPK QKFAFLAEFNFARFHFLRPLVIYVSFALALYLIWRMGKGWKWLVYAAVAAQLMVLAPF NEEYTYGVHYNAPTFREFYASEQFKEIKEYIGRPQDSYRVASIGLHPSIAQYNGFYTL DTYNNLYPLSYKYEFRKIIEKELEKNSRLKQYFDEWGSRCYLFVDELGKRYDFKKNSK KTINNLQLNTDVFKKMGGRYIFSSVPIMNAEQNHLALVKTFDHKDSAWRIYLYETR*" /label="ykoS CDS" gene 1247834..1249528 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /label="ykoS gene" CDS 1249541..1250554 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /EC_number="2.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389222.1" /db_xref="EnsemblGenomes-Gn:BSU13390" /db_xref="EnsemblGenomes-Tr:CAB13196" /db_xref="GOA:O34755" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13263" /db_xref="UniProtKB/Swiss-Prot:O34755" /translation="MKQSQPVLTIVVPCFNEEEVFQETSHQLTEVVDDLIEEKLIAED SKILFVDDGSKDRTWALIAMESIRNKKVTGLKLACNVGHQKALLAGLHKAKNRSDCVI SIDADLQDDISVIRDFMLKYHEGCEIVYGVRRSRKTDTFFKRTTALGFYRLMNKLGIK LIYNHADFRLMNKRSLEELERYPEANLFLRGIVPMIGFKSAEVLYDRKERFAGKTKYP LKKMLSFAFNGITSFSVAPIRFFTLLGFVLFFLSAVAGIGAFIQKLLGHTNAGWASLI ISIWFLGGLQLMGIGIIGEYIGTIFSEVKRRPKYAIDIDLYNEQLSPLQRQEKERLEK KYS*" /label="ykoT CDS" gene 1249541..1250554 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /label="ykoT gene" downshifts 1250539 /Source="Nicolas_upshifts" /id="D733" /incds=0 /nref=13 /ntot=35 /MaxReadThrough="0.53349" /MaxDrop="4.80671" /score="19.4012674" /energy="-13.7" /TU="NA" /idTUdmin="U1082" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(1250580..1252415) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /EC_number="6.5.1.1" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12215643, 16497325, 17293412, 23691176, 25355514, 26826709" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12215643, 16497325, 17293412, 23691176, 25355514, 26826709; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit; 5'-2-deoxyribose-5-phosphate (dRP) lyase" /protein_id="NP_389223.1" /db_xref="EnsemblGenomes-Gn:BSU13400" /db_xref="EnsemblGenomes-Tr:CAB13197" /db_xref="GOA:O34398" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR014143" /db_xref="InterPro:IPR014145" /db_xref="InterPro:IPR014146" /db_xref="InterPro:IPR033652" /db_xref="SubtiList:BG13264" /db_xref="UniProtKB/Swiss-Prot:O34398" /translation="MAFTMQPVLTSSPPIGAEWRYEVKYDGYRCILRIHSSGVTLTSR NGVELSSTFPEITQFAKTAFQHLEKELPLTLDGEIVCLVNPCRADFEHLQVRGRLKRP DKIQESANARPCCFLAFDLLERSGEDVTLLSYLDRKKSLRELISAAKLPASPDPYAKE TIQSIPCYDHFDQLWEMVIKYDGEGIVAKKTNSKWLEKKRSSDWLKYKNFKQAYVCIT GFNPNNGFLTVSVLKNGIMTPIASVSHGMRDEEKSAIREIMEQHGHQTPSGEFTLEPS ICAAVQYLTILQGTLREVSFIGFEFQMDWTECTYAQVIRHSKPVHPKLQFTSLDKIIF EKNKKTKEDFIQYMIEVSDYLLPFLKNRAVTVIRYPHGSRSESFFQKNKPDYAPDFVQ SFYDGSHEHIVCEDMSTLLWLCNQLALEFHVPFQTIKSRRPAEIVIDLDPPSRDDFLM AVQAANELKRLLDSFGITSYPKLSGNKGIQLYIPLSPEAFTYEETRQFTQLIAEYCTN AFPELFTTERLIKNRHCKLYLDYLQHAEGKTIICPYSTRGNELGTVAAPLYWHEVQSS LTPALFTIDTVIDRIKKQGCPFFDFYRNPQDEPLSAILHQLKKKS*" /label="ligD CDS" gene complement(1250580..1252415) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /label="ligD gene" downshifts complement(1250629) /Source="Nicolas_upshifts" /id="D734" /incds=0 /nref=10 /ntot=54 /MaxReadThrough="0.67916" /MaxDrop="5.08051" /score="-8.48510187" /energy="-13.7" /TU="NA" /idTUdmin="U1083" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1252419..1253354) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11095673, 12215643, 16497325, 16780573, 23691176, 25355514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11095673, 12215643, 16497325, 16780573, 23691176, 25355514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit Ku; AP/deoxyribose 5'-phosphate (5'-dRP)-lyase" /protein_id="NP_389224.1" /db_xref="EnsemblGenomes-Gn:BSU13410" /db_xref="EnsemblGenomes-Tr:CAB13198" /db_xref="GOA:O34859" /db_xref="InterPro:IPR006164" /db_xref="InterPro:IPR009187" /db_xref="InterPro:IPR016194" /db_xref="SubtiList:BG13265" /db_xref="UniProtKB/Swiss-Prot:O34859" /translation="MNRTPSLHTKEKKGFIDMHTMWKGSISFGLVNIPIKLYAATEDK DIKLRSLHKEDHAPIKYEKVCTNCEKTLSPDEIVKGYEYVKGKYVVLTDEDLKSLKQE HEEKAVEIVDFVQLQEIDPIYFNRSYFVGPGDNGTKAYTLLREALRSTGKIGIANMTI RSKQQLAILRVYENCIVMESIHYPDEVRSAAQVPGVPDQSNVNDKELQTAITLIDELT AKFEPEKYEDTYRQALLQRVNDKLENKETAVTPDKAPPREDVIDLVSALQASIDRTRR PNRETPAAAPAQAAEPKGAGDKKQKTTRKKASGTS*" /label="ligV CDS" gene complement(1252419..1253354) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /label="ligV gene" promotor_-10 complement(1253325..1253336) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1253335) /Source="Nicolas_upshifts" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1253351..1253357) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1253391..1255793) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11728710, 17010156, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11728710, 17010156, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="YP_054577.2" /db_xref="EnsemblGenomes-Gn:BSU13420" /db_xref="EnsemblGenomes-Tr:CAB13199" /db_xref="GOA:O34311" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR005330" /db_xref="InterPro:IPR029787" /db_xref="InterPro:IPR035919" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG13266" /db_xref="UniProtKB/Swiss-Prot:O34311" /translation="MEIHVTYNTTLICLSILIACTASYISLELSRKVTINTGLKSKIW LIGGSLIMGFGIWSMHFVGMMAVHMEMPMEYEFMPLMAAIGASVSGSFVSLYFVSRHI LTYYRLLTGSVVLGASIASMHYIGMSAISRVMIIYEPILFTVSIIIAIAASFVSLKIF FDLAVKKHSEHLIFYKGVSSIVMGIGISGMHYTGMLAATFHKDMAPPGSHMEVQTFHW SIFVTLIIFCIQTLLLFSSHADRKFIKQSERIKDNEQRFQSLIVHNIDAIFILSLEGD IISSNHAGEEMISKFGFSMHDWRNYTSLKVKRLFEQVKKDKQAMNSDSDLITEKGQFH LNITLIPVEVNQELDSIYVICKDMTKQYKAEKEIHRMAHYDSLTDLPNRRHAISHLTK VLNREHSLHYNTVVFFLDLNRFKVINDALGHNVGDQLLQFAAKRLSSVVPDNGFIARL GGDEFIIILTDANTGTGEADVLARKIIQKFKKPFKIQDHTLVTSVSIGIAISPKDGTD GLELMKKADMAMYAAKERNKSKYRYYSFSIGNKETVKLNQEMVLREAIENDRFVLHYQ PQFSVKKQKMTGAEALIRLVTPDGQLRPPGEFIGVAEETGLIIDIGKWIIDEACKQAR IWHDKGYDLSVAINISARQFQSKDLIPLIKDTLNKYQLPPQLLEVEVTESMTMDNLNH SKKVLSSLTELGIRISIDDFGTGHSSLSYLKDFPIHRLKIDKSFIDDIQTHPKSEQIT GAIIAMGHQLSLQVIAEGVENAAQKQLLFEKGCDHLQGFFFSRPIPPEQFEQFIIEQP SQ*" /label="dgcW CDS" gene complement(1253391..1255793) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /label="dgcW gene" downshifts complement(1253423) /Source="Nicolas_upshifts" /id="D735" /incds=0 /nref=13 /ntot=101 /MaxReadThrough="1.93589" /MaxDrop="3.26543" /score="6.55794882" /energy="-9" /TU="NA" /idTUdmin="U1084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1255641..1255843) /Source="Nicolas_S_feature" /locus_tag="new_1409579_1409781_c" /HighExp="Cold, GM 25, GM 10, GM 45, GM 15, GM-0.2, GM-0.1, GM 5, GM 90, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S479" promotor_-10 complement(1255832..1255850) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1255843) /Source="Nicolas_upshifts" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1255864..1255871) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1255910..1255917 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1255931..1255950 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1255943 /Source="Nicolas_upshifts" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="upshifts" CDS 1255974..1256639 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23687963; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389226.1" /db_xref="EnsemblGenomes-Gn:BSU13430" /db_xref="EnsemblGenomes-Tr:CAB13200" /db_xref="GOA:O34908" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13267" /db_xref="UniProtKB/Swiss-Prot:O34908" /translation="MIHKHETRELVAIEELVMSWIEAFKSLSYFGIFLALSIEFIPAE VVLPLAGYWVSKGDMTLAGVVLAGSLGGVAGPLTLYWIGRYGGRPFLERFGKYLFIKP EALDKSDNFFKKHGGFVAFSGRFLPGIRTLISIPCGIAKMNVWVFSLYTFIAMLPITF VYVYLGVKLGENWKAVGSILDQYMLPIGIAILALFLLYLLMKKRKKRTHSEQLSVFLK NKR*" /label="ykoX CDS" gene 1255974..1256639 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /label="ykoX gene" promotor_-10 complement(1256508..1256527) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1256525) /Source="Nicolas_upshifts" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1256541..1256550) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1256634..1256641 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1256656..1256675 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1256669 /Source="Nicolas_upshifts" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1256695..1256828 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /product="manganese ion riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="mnrW RNA" gene 1256695..1256828 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /label="mnrW gene" CDS 1256716..1257690 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 15849754, 16850406, 25794618, 25794619; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative manganese-related ion transporter" /protein_id="NP_389227.1" /db_xref="EnsemblGenomes-Gn:BSU13440" /db_xref="EnsemblGenomes-Tr:CAB13201" /db_xref="GOA:O34997" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13268" /db_xref="UniProtKB/Swiss-Prot:O34997" /translation="MYSGNKVVISWIVSIGFVGMPEFMSSKTFALCRQRSFLHGPAGI RSDEEKENNFFGRVSFMDAALLLEYGWVLLVLIGLEGILAADNALVMAVMVKHLPEEK RKKALFYGLAGAFVLRFGSLFAISFLVNVWQVQAIGAIYLLYISASHLLKRYVFKKED THKETKQSGFWPTVLKVELADIAFAVDSILAAVALAVTLPGTSLPKIGGLDGGQFLVI LAGGIIGLVIMRFAASMFVKLLKERPSLETAAFVIVGWVGVKLALYTLAHRDIAVVSE HFIHSGTWKLIFWGVLAAIAVCGWFMSGGKKQPEGAQNEQKNSTRERA*" /label="ykoY CDS" gene 1256716..1257690 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /label="ykoY gene" downshifts 1256779 /Source="Nicolas_upshifts" /id="D736" /incds=1 /nref=38 /ntot=211 /MaxReadThrough="5.00041" /MaxDrop="4.46498" /score="15.8563987" /energy="-15" /TU="U1085,U1087" /idTUdmin="U1085" /TUdmin="-902" /isTUend="FALSE" /label="downshifts" downshifts 1257678 /Source="Nicolas_upshifts" /id="D737" /incds=0 /nref=16 /ntot=175 /MaxReadThrough="2.59801" /MaxDrop="4.20782" /score="24.4740487" /energy="-13.7" /TU="NA" /idTUdmin="U1085" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1257800..1257808 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1257822..1257830 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1257832 /Source="Nicolas_upshifts" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="upshifts" S_feature 1257835..1257921 /Source="Nicolas_S_feature" /locus_tag="new_1411773_1411859" /HighExp="M9-stat, T1.30H, T1.0H, T0.30H, T2.0H, T2.30H, HiTm, M0t90, T3.0H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29969800000000002" /TUshortSig="SigI" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S480" promotor_-35 1257894..1257901 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1257915..1257934 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1257923 /Source="Nicolas_upshifts" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="upshifts" CDS 1257954..1258709 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma factor (heat stress responsive)" /protein_id="NP_389228.1" /db_xref="EnsemblGenomes-Gn:BSU13450" /db_xref="EnsemblGenomes-Tr:CAB13218" /db_xref="GOA:O31654" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014244" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG13269" /db_xref="UniProtKB/Swiss-Prot:O31654" /translation="MKPVLSLLFKLGKKKQTLEKAVESIQKGNKDLQNELIQQYKPFI AKTVSSVCKRYIDEKDDEFSIGLIAFNEAIEKYSPEKGNSLLAFAELIIKRKVIDYIR KEARSAQNINIDLQEGDDQESSQSLIEAELSIDEYRRQIEQEQRREEILYFQKQLKDY GLSFKELLENSPKHTDARQNAIKVAMTLVEHEELAAILYTKKQLPVKQLEQLVSVSRK TIERNRKYIIAMCIIITGDYIYLKDYLKGVLHS*" /label="sigI CDS" gene 1257954..1258709 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /label="sigI gene" CDS 1258706..1259851 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17185538, 23199363, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17185538, 23199363, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="sigmaI modulating factor" /protein_id="NP_389229.1" /db_xref="EnsemblGenomes-Gn:BSU13460" /db_xref="EnsemblGenomes-Tr:CAB13219" /db_xref="GOA:O31655" /db_xref="InterPro:IPR024449" /db_xref="SubtiList:BG13272" /db_xref="UniProtKB/Swiss-Prot:O31655" /translation="MRRGIIVEKNKKFVTLLTPDGQFLKAKNDRHSYEIGEEIMLPSE TRMGRRASFFDFFKLRPFKMGIFTMTAIMLFIFIVLPVFSNNKAYAYMTIDINPSVEM ALNSDYEVIELTPLNDEGQKVVNDIDDWEKTDFKKVIDDIITDCSEHGYVKKSKEILI STVYENTEDNTYKKAVKKQLNDVTEKYKTTYRMESLESDMQTREKAKKEGVSTGSYIK SNEKNDNKDIKDDSSKPSGEEDQKSDENEDENTDQTDTQDSKQGDNEQLNDADSGDQK EEKADDQIDDSDKDKKIKESDENTNTEKDGDHEQTPIQDPQDKGNENNGADKGQSQYH RDWNNGEQGKNRSSSRRDNASDRRNPNGYSSDNHSAKNEDSPSAPGE*" /label="rsgI CDS" gene 1258706..1259851 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /label="rsgI gene" S_feature 1259852..1261011 /Source="Nicolas_S_feature" /locus_tag="new_1413790_1414949" /HighExp="HiTm, G135, G180, C30, G150, Cold, S8, MG 25, H2O2, Lbstat" /AntisenseName="ykrK" /AntisenseCor="0.122248209149143" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigI" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S481" CDS complement(1259862..1260056) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:3009397, 3112127, 3121585, 9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009397, 3112127, 3121585, 9852018; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_389230.1" /db_xref="EnsemblGenomes-Gn:BSU13470" /db_xref="EnsemblGenomes-Tr:CAB13220" /db_xref="GOA:P04833" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10788" /db_xref="UniProtKB/Swiss-Prot:P04833" /translation="MASRNKLVVPGVEQALDQFKLEVAQEFGVNLGSDTVARANGSVG GEMTKRLVQQAQSQLNGTTK*" /label="sspD CDS" gene complement(1259862..1260056) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /label="sspD gene" downshifts complement(1259869) /Source="Nicolas_upshifts" /id="D738" /incds=0 /nref=24 /ntot=36 /MaxReadThrough="1.67859" /MaxDrop="4.68215" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1090" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1260099..1260110) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1260109) /Source="Nicolas_upshifts" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1260125..1260131) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1260187..1260888) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22447908, 23042994" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22447908, 23042994; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of quality control" /protein_id="NP_389231.1" /db_xref="EnsemblGenomes-Gn:BSU13480" /db_xref="EnsemblGenomes-Tr:CAB13221" /db_xref="InterPro:IPR014975" /db_xref="SubtiList:BG13273" /db_xref="UniProtKB/Swiss-Prot:O31656" /translation="MNIFKLSRTDMVRLLYSLKGQGEHSPLDILVQSANMSAEKAANH LEIPEFLTRYERKKQKKEYGLSTNEIVELGNLCELTSLKSTAIQNWVKRDIKDLIGHP ELGKKYSIEQAVILLIVRDLKSIYDFEHIRAILKVAFNTISDRSDDVISPIAYYESCA YVLDAIHHQDTPSMKESNLQEIAEQETERLRHRFEELNDSQWLKIRQIIAITVLSILT FHIQATAHKMTADIL*" /label="htpK CDS" gene complement(1260187..1260888) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /label="htpK gene" downshifts complement(1260221) /Source="Nicolas_upshifts" /id="D739" /incds=0 /nref=174 /ntot=231 /MaxReadThrough="2.96889" /MaxDrop="5.30355" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1260889..1260969) /Source="Nicolas_S_feature" /locus_tag="new_1414827_1414907_c" /HighExp="LBGtran, dia0, LBGexp, Lbexp, Oxctl, G180, M0t45, C90, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S482" promotor_-10 complement(1260961..1260980) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1260969) /Source="Nicolas_upshifts" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1260985..1260992 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1260994..1261001) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1261006..1261025 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1261013 /Source="Nicolas_upshifts" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="upshifts" CDS 1261059..1261955 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11860552, 12081643, 16076848, 16573693, 22447908, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane protease" /protein_id="NP_389232.1" /db_xref="EnsemblGenomes-Gn:BSU13490" /db_xref="EnsemblGenomes-Tr:CAB13222" /db_xref="GOA:O31657" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR022919" /db_xref="SubtiList:BG13274" /db_xref="UniProtKB/Swiss-Prot:O31657" /translation="MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDP MALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSR SAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHI TNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILG SLVVFAYSRHREFHADRGGADLAGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGK KRSSLFSTHPDLDERIRRLEAK*" /label="htpX CDS" gene 1261059..1261955 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /label="htpX gene" downshifts 1261949 /Source="Nicolas_upshifts" /id="D740" /incds=0 /nref=203 /ntot=268 /MaxReadThrough="3.02778" /MaxDrop="6.27746" /score="38.5173589" /energy="-13.4" /TU="NA" /idTUdmin="U1092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1262060..1262064 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1262080..1262099 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1262084 /Source="Nicolas_upshifts" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="upshifts" CDS 1262129..1263478 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /EC_number="3.6.3.12" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 23963175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 23963175; Product type t : transporter" /codon_start=1 /transl_table=11 /product="K+-transporting ATPase" /protein_id="NP_389233.1" /db_xref="EnsemblGenomes-Gn:BSU13500" /db_xref="EnsemblGenomes-Tr:CAB13223" /db_xref="GOA:O31658" /db_xref="InterPro:IPR003445" /db_xref="SubtiList:BG13275" /db_xref="UniProtKB/Swiss-Prot:O31658" /translation="MRLKFGKLIQALSPAQLIALYYFLAVTVAVILLSLPAAHKPGAD WTFIDALFTAVSSVSVTGLTVVDTADTFSTIGIFILAFVLQFGGIGIMTLGTFIWLIM GKRIGLKERKLIMVDQNQSQFSGIVNLMKQVLFLILWIEFFGGLILGTYFLTYYDSYQ EAYLHGFFASISATTNGGFDITGNSMIPFRHDYFVQFITMLLIIFGAIGFPVLVEVKD FLFSKHRRYPFTLFTKITTITFGSLVLFGAIGIFALEANHAFAGKSWHDILFLSLFQS TATRSGGLATIDISQLSDSTLFFICALMFIGASPSSVGGGIRTTTFALNLLALFHFAR GNKAVKVFKRELHPADLMKSLVVTMMAILLVFGATLILTITEKHSLLELLFEVCSAFG TTGLSLGITADLSSVGKCVIMIVMFIGRIGILTFLYLIGRKEIEANYHYPKERVIIG* " /label="ktrD CDS" gene 1262129..1263478 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /label="ktrD gene" downshifts 1263466 /Source="Nicolas_upshifts" /id="D741" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="0.838800000000001" /MaxDrop="4.37717" /score="20.0478288" /energy="-10.7" /TU="NA" /idTUdmin="U1093" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1263527..1263533 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1263547..1263558 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1263555..1263622 /Source="Nicolas_S_feature" /locus_tag="new_1417493_1417560" /HighExp="S8, S6, S7, S5, ferm, nit, BT, B36, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S483" upshifts 1263555 /Source="Nicolas_upshifts" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1263623..1263778 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097718.1" /db_xref="EnsemblGenomes-Gn:BSU13509" /db_xref="EnsemblGenomes-Tr:CAX52609" /db_xref="UniProtKB/Swiss-Prot:C0H402" /translation="MKRKAEVNEAIKNNNTPTESMDPNSYKTQYHDDPNFRGANRNSK QGQQGGM*" /label="ykzP CDS" gene 1263623..1263778 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /label="ykzP gene" CDS 1263781..1263957 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389234.1" /db_xref="EnsemblGenomes-Gn:BSU13510" /db_xref="EnsemblGenomes-Tr:CAB13224" /db_xref="SubtiList:BG13333" /db_xref="UniProtKB/Swiss-Prot:O31659" /translation="MKKNRHSRDMQNHKKPMNKKVLEEEFSSELGDYNAGKIIETLEV TKPEKKKEKNKKQQ*" /label="ykzE CDS" gene 1263781..1263957 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /label="ykzE gene" promotor_no_box 1263847..1263947 /Source="Nicolas_upshift_promotors" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1263907 /Source="Nicolas_upshifts" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1263953 /Source="Nicolas_upshifts" /id="D742" /incds=0 /nref=56 /ntot=112 /MaxReadThrough="2.40289" /MaxDrop="8.38761" /score="26.5107018" /energy="-19.7" /TU="NA" /idTUdmin="U1094" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1264000..1265022) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /EC_number="2.3.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral membrane protein; putative acyltransferase" /protein_id="NP_389235.1" /db_xref="EnsemblGenomes-Gn:BSU13520" /db_xref="EnsemblGenomes-Tr:CAB13225" /db_xref="GOA:O31660" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG13276" /db_xref="UniProtKB/Swiss-Prot:O31660" /translation="MSKSRDSYFDNAKFLLIFLVVFGHILRSFINDNHFMLYLYKFIY TFHMPAFILVSGYFAKGFKRAGYVKKLAVKLIIPYLIFQIIYSVFYYIMQDESMANVN PIDPQWSLWFLVSLFFWNLLLYPFSKLSKQWALFVSCGIAVLIGYLDFVSSTLSLSRT FVFLPMFLVGFYLNKHHFDLLRSKRGKQIALGVLAAVFVICWGIDFDYSFLFGSKPYS SFGDVTLVSGLSRIGWYVLAFGATFSFLALVPQKRYFFTKWGTRTFYVYLLHGFIIKT LRQVGLEDWLTDYQSLVILLLLTAALTSVLSSNFVKTVAQPFIELRMTSLLQFVRGTG KNAYLK*" /label="ykrP CDS" gene complement(1264000..1265022) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /label="ykrP gene" downshifts complement(1264023) /Source="Nicolas_upshifts" /id="D743" /incds=0 /nref=11 /ntot=58 /MaxReadThrough="2.29259" /MaxDrop="3.64731" /score="30.4184602" /energy="-16.9" /TU="NA" /idTUdmin="U1096" /TUdmin=92 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1265067..1265086) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1265083) /Source="Nicolas_upshifts" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1265098..1265104) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1265211..1265219 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1265227 /Source="Nicolas_upshifts" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1265230..1265248 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1265275..1267491 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11069677, 12169614, 16166384, 25701730" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 12169614, 16166384, 25701730; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_389236.1" /db_xref="EnsemblGenomes-Gn:BSU13530" /db_xref="EnsemblGenomes-Tr:CAB13226" /db_xref="GOA:O31661" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13277" /db_xref="UniProtKB/Swiss-Prot:O31661" /translation="METLGVQTNSELREELNRLKEENARLKKELNQHQVIVNNTLDAI FICDNEMRIVQANEATERMLQVDSEDLKKRSVLDFLFSIPKDELNLSVKKFFKKGFLW KEVPIRLDCGATKYIEFLAKRGIGEDFFFVVMRDISSKKILEREFSMNEQLFKDLFDR AVDGIVLFDKDGGFIDANLSFCKSFEINHNELSHLSLYEFIDSGSRKDFDNIWKALNR KGKAKGELPVKLRSGVQKLFEFTITSNIISGFYMSIMRDITEKRSMELQLFKSEERFR EIFENAMDAIIIWSNDGRIVKANQSACKIFELPMNLLLKRKLCDFLVDSQQKYSITKR KYAKYGEIREELLFQMGNGQFKELEFTSKRTILENQHLTILRNVSDRKRMEKELRESE LKFRKVFNGSMDGNVLFDNQYRIIDANPLASHILGLSHEEIKQHSLLDIISAYEIENL ASPARQINFDEMDNEIPFLLSSGDNRKLEFSFKRNIIQNMNLAIFKDVTERKELEERL RKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLKGSVEGDYALYFNVITSELKRIES IITEFLILAKPQAIMYEEKHVTQIMRDTIDLLNAQANLSNVQMQLDLIDDIPPIYCEP NQLKQVFINILKNAIEVMPDGGNIFVTIKALDQDHVLISLKDEGIGMTEDKLKRLGEP FYTTKERGTGLGLMVSYKIIEEHQGEIMVESEEGKGTVFHITLPVRQNAEERRNDE*" /label="kinE CDS" gene 1265275..1267491 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /label="kinE gene" S_feature complement(1267266..1268206) /Source="Nicolas_S_feature" /locus_tag="new_1421204_1422144_c" /HighExp="Pyr, Glucon, C30, Glu, Mal, M/G, G/S, Heat, Fru, B36" /AntisenseName="ogt" /AntisenseCor="-0.33210294457391598" /AntisenseRegPval="-7.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S484" promotor_-35 1267344..1267351 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1267366..1267385 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1267368 /Source="Nicolas_upshifts" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="upshifts" CDS 1267488..1267985 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /EC_number="2.1.1.63" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2105461, 2308822, 2359121, 2506524, 7565865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105461, 2308822, 2359121, 2506524, 7565865; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O6-alkylguanine DNA alkyltransferase" /protein_id="NP_389237.1" /db_xref="EnsemblGenomes-Gn:BSU13540" /db_xref="EnsemblGenomes-Tr:CAB13227" /db_xref="GOA:P11742" /db_xref="InterPro:IPR001497" /db_xref="InterPro:IPR008332" /db_xref="InterPro:IPR014048" /db_xref="InterPro:IPR023546" /db_xref="InterPro:IPR036217" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036631" /db_xref="SubtiList:BG10848" /db_xref="UniProtKB/Swiss-Prot:P11742" /translation="MNYYTTAETPLGELIIAEEEDRITRLFLSQEDWVDWKETVQNTE HKETPNLAEAKQQLQEYFAGERKTFSLPLSQKGTPFQQKVWQALERIPYGESRSYADI AAAVGSPKAVRAVGQANKRNDLPIFVPCHRVIGKNSALTGYAGSKTEIKAFLLNIERI SYKEK*" /label="ogt CDS" gene 1267488..1267985 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /label="ogt gene" S_feature 1267986..1268225 /Source="Nicolas_S_feature" /locus_tag="new_1421924_1422163" /HighExp="Lbstat, S2, BT, BC, LPhT, dia15, LBGstat, M0t90, M9-stat, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.981549" /TUshortSig="SigA, SigH" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S485" CDS 1268075..1268200 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513954.1" /translation="MKPSRSEKLAVFAELFVKLHILSSAQKDEIINVNKKKQKNR*" /label="hypothetical protein CDS" gene 1268075..1268200 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /label="gene" downshifts 1268193 /Source="Nicolas_upshifts" /id="D744" /incds=0 /nref=80 /ntot=239 /MaxReadThrough="1.90528" /MaxDrop="5.2481" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1268234..1269295) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /EC_number="5.3.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14551435, 15102328, 16511105, 17690466, 18156470" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14551435, 15102328, 16511105, 17690466, 18156470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose-1-phosphate isomerase (methionine salvage pathway)" /protein_id="NP_389238.1" /db_xref="EnsemblGenomes-Gn:BSU13550" /db_xref="EnsemblGenomes-Tr:CAB13228" /db_xref="GOA:O31662" /db_xref="InterPro:IPR000649" /db_xref="InterPro:IPR005251" /db_xref="InterPro:IPR011559" /db_xref="InterPro:IPR027363" /db_xref="PDB:2YRF" /db_xref="PDB:2YVK" /db_xref="SubtiList:BG13278" /db_xref="UniProtKB/Swiss-Prot:O31662" /translation="MTHSFAVPRSVEWKETAITILNQQKLPDETEYLELTTKEDVFDA IVTLKVRGAPAIGITAAFGLALAAKDIETDNVTEFRRRLEDIKQYLNSSRPTAINLSW ALERLSHSVENAISVNEAKTNLVHEAIQIQVEDEETCRLIGQNALQLFKKGDRIMTIC NAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLI TDSMAAHTMKEKQISAVIVGADRIAKNGDTANKIGTYGLAILANAFDIPFFVAAPLST FDTKVKCGADIPIEERDPEEVRQISGVRTAPSNVPVFNPAFDITPHDLISGIITEKGI MTGNYEEEIEQLFKGEKVH*" /label="mtnA CDS" gene complement(1268234..1269295) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /label="mtnA gene" downshifts complement(1268251) /Source="Nicolas_upshifts" /id="D745" /incds=0 /nref=261 /ntot=286 /MaxReadThrough="4.47312" /MaxDrop="7.97339" /score="34.04363" /energy="-17.1" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(1269303..1270496) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /EC_number="2.7.1.100" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:210167, 11545674, 15102328, 17522047, 23649237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 210167, 11545674, 15102328, 17522047, 23649237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose kinase (methionine salvage pathway, promiscuous)" /protein_id="NP_389239.2" /db_xref="EnsemblGenomes-Gn:BSU13560" /db_xref="EnsemblGenomes-Tr:CAB13229" /db_xref="GOA:O31663" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR009212" /db_xref="InterPro:IPR011009" /db_xref="PDB:2OLC" /db_xref="PDB:2PU8" /db_xref="PDB:2PUI" /db_xref="PDB:2PUL" /db_xref="PDB:2PUN" /db_xref="PDB:2PUP" /db_xref="SubtiList:BG13279" /db_xref="UniProtKB/Swiss-Prot:O31663" /translation="MGVTKTPLYETLNESSAVALAVKLGLFPSKSTLTCQEIGDGNLN YVFHIYDQEHDRALIIKQAVPYAKVVGESWPLTIDRARIESSALIRQGEHVPHLVPRV FYSDTEMAVTVMEDLSHLKIARKGLIEGENYPHLSQHIGEFLGKTLFYSSDYALEPKV KKQLVKQFTNPELCDITERLVFTDPFFDHDTNDFEEELRPFVEKLWNNDSVKIEAAKL KKSFLTSAETLIHGDLHTGSIFASEHETKVIDPEFAFYGPIGFDVGQFIANLFLNALS RDGADREPLYEHVNQVWETFEETFSEAWQKDSLDVYANIDGYLTDTLSHIFEEAIGFA GCELIRRTIGLAHVADLDTIVPFDKRIGRKRLALETGTAFIEKRSEFKTITDVIELFK LLVKE*" /label="mtnK CDS" gene complement(1269303..1270496) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /label="mtnK gene" downshifts 1269363 /Source="Nicolas_upshifts" /id="D746" /incds=1 /nref=1 /ntot=51 /MaxReadThrough="3.02938" /MaxDrop="3.49719" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts complement(1270583) /Source="Nicolas_upshifts" /id="D747" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="8.61071" /MaxDrop="3.05641" /score="27.7981655" /energy="-17.6" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-2750" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1270589..1270745) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="12: Regulatory functions" /label="mswC RNA" gene complement(1270589..1270745) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /label="mswC gene" promotor_-10 complement(1270780..1270799) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1270781) /Source="Nicolas_upshifts" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1270815..1270822) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1270825..1270828 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1270829..1271608) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /EC_number="3.5.1.3" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12022921, 19464248, 19596042, 21288482, 23944997, 24387040; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ketoglutaramate omega-amidase" /protein_id="NP_389240.1" /db_xref="EnsemblGenomes-Gn:BSU13570" /db_xref="EnsemblGenomes-Tr:CAB13230" /db_xref="GOA:O31664" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG13280" /db_xref="UniProtKB/Swiss-Prot:O31664" /translation="MKWTISCLQFDISYGKPSENIKKAEFFIEKESKHADVLVLPELW TTGYDLANLDELADEDGRSAQSWLKKTAKKHGVHIVAGSVAVRKNSDVYNTMYIADKE GQIIKEYRKAHLFQLMDEHLYLSAGSEDGYFELDGVKSSGLICYDIRFPEWIRKHTTK GANVLFISAEWPLPRLDHWKSLLIARAIENQCFVAACNCTGSNPDNEFAGHSLIIDPW GRVLAEGGREEGIVRAEIDLQESAEVRESIPVFDDIRKDLY*" /label="mtnU CDS" gene complement(1270829..1271608) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /label="mtnU gene" promotor_-10 1270844..1270863 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1270853 /Source="Nicolas_upshifts" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1271301..1271308 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-35" promotor_-10 1271321..1271340 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-10" upshifts 1271336 /Source="Nicolas_upshifts" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="upshifts" S_feature 1271343..1271660 /Source="Nicolas_S_feature" /locus_tag="new_1425281_1425598" /HighExp="LoTm, S8, C30, BC, S7, B36, B60, T2.0H, Sw, UNK1" /AntisenseName="mtnU" /AntisenseCor="0.77659263363209297" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S486" promotor_-35 1271630..1271637 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1271638..1271657) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1271652..1271671 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1271652) /Source="Nicolas_upshifts" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" upshifts 1271662 /Source="Nicolas_upshifts" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1271673..1271680) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1271703..1272899 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /EC_number="2.6.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15102328, 23429746, 24387040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15102328, 23429746, 24387040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine-glutamine aminotransferase" /protein_id="NP_389241.1" /db_xref="EnsemblGenomes-Gn:BSU13580" /db_xref="EnsemblGenomes-Tr:CAB13231" /db_xref="GOA:O31665" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13281" /db_xref="UniProtKB/Swiss-Prot:O31665" /translation="MKFEQSHVLKELPKQFFASLVQKVNRKLAEGHDVINLGQGNPDQ PTPEHIVEEMKRAVADPENHKYSSFRGSYRLKSAAAAFYKREYGIDLDPETEVAVLFG GKAGLVELPQCLLNPGDTILVPDPGYPDYWSGVTLAKAKMEMMPLVKDRAFLPDYSSI TAEIREQAKLMYLNYPNNPTGAVATSEFFEDTVRFAAENGICVVHDFAYGAVGFDGCK PLSFLQTEGAKDIGIEIYTLSKTYNMAGWRVGFAVGNASVIEAINLYQDHMFVSLFRA TQEAAAEALLADQTCVAEQNARYESRRNAWITACREIGWDVTAPAGSFFAWLPVPEGY TSEQFSDLLLEKANVAVAAGNGFGEYGEGYVRVGLLTSEERLKEAAYRIGKLNLFTQK SIDKTL*" /label="mtnE CDS" gene 1271703..1272899 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /label="mtnE gene" promotor_-35 1272881..1272888 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1272903..1272922 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1272922 /Source="Nicolas_upshifts" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1272938..1273038 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="16.3: Control" /label="mswD RNA" gene 1272938..1273038 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /label="mswD gene" downshifts 1273037 /Source="Nicolas_upshifts" /id="D748" /incds=0 /nref=49 /ntot=190 /MaxReadThrough="7.27369" /MaxDrop="4.19981" /score="-1.80590532" /energy="-10.7" /TU="U1103,U1104" /idTUdmin="U1101" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS 1273123..1274340 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /EC_number="5.3.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 16737967, 18403380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 16737967, 18403380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2,3-diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1-P enolase)" /protein_id="NP_389242.2" /db_xref="EnsemblGenomes-Gn:BSU13590" /db_xref="EnsemblGenomes-Tr:CAB13232" /db_xref="GOA:O31666" /db_xref="InterPro:IPR000685" /db_xref="InterPro:IPR017443" /db_xref="InterPro:IPR017717" /db_xref="InterPro:IPR033966" /db_xref="InterPro:IPR036376" /db_xref="InterPro:IPR036422" /db_xref="PDB:2ZVI" /db_xref="SubtiList:BG13282" /db_xref="UniProtKB/Swiss-Prot:O31666" /translation="MSELLATYLLTEPGADTEKKAEQIATGLTVGSWTDLPLVKQEQM QKHKGRVIKVEEREGTAASEKQAVITIAYPEINFSQDIPALLTTVFGKLSLDGKIKLI DLHFSEAFKRALPGPKFGVYGIRKLLGEFERPLLMSIFKGVIGRDLSDIKEQLRQQAL GGVDLIKDDEIFFETGLAPFETRIAEGKQILKETYEQTGHKTLYAVNLTGRTADLKDK ARRAAELGADALLFNVFAYGLDVMQGLAEDPEIPVPIMAHPAVSGAFTSSPFYGFSHA LLLGKLNRYCGADFSLFPSPYGSVALPRADALAIHEECVREDAFNQTFAVPSAGIHPG MVPLLMRDFGIDHIINAGGGVHGHPNGAQGGGRAFRAIIDAVLEAQPIDEKAEQCKDL KLALDKWGKAEAV*" /label="mtnW CDS" gene 1273123..1274340 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /label="mtnW gene" CDS 1274337..1275044 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /EC_number="3.1.3.87" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 17654724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 17654724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphatephosphatase (HK-MTPenyl-1-P phosphatase)" /protein_id="NP_389243.1" /db_xref="EnsemblGenomes-Gn:BSU13600" /db_xref="EnsemblGenomes-Tr:CAB13233" /db_xref="GOA:O31667" /db_xref="InterPro:IPR006384" /db_xref="InterPro:IPR017718" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:2FEA" /db_xref="SubtiList:BG13283" /db_xref="UniProtKB/Swiss-Prot:O31667" /translation="MTTRKPFIICDFDGTITMNDNIINIMKTFAPPEWMALKDGVLSK TLSIKEGVGRMFGLLPSSLKEEITSFVLEDAKIREGFREFVAFINEHEIPFYVISGGM DFFVYPLLEGIVEKDRIYCNHASFDNDYIHIDWPHSCKGTCSNQCGCCKPSVIHELSE PNQYIIMIGDSVTDVEAAKLSDLCFARDYLLNECREQNLNHLPYQDFYEIRKEIENVK EVQEWLQNKNAGESSLK*" /label="mtnX CDS" gene 1274337..1275044 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /label="mtnX gene" CDS 1275002..1275631 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /EC_number="4.2.1.109" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 18391471, 23285211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 18391471, 23285211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)" /protein_id="NP_389244.1" /db_xref="EnsemblGenomes-Gn:BSU13610" /db_xref="EnsemblGenomes-Tr:CAB13234" /db_xref="GOA:O31668" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR017714" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG13284" /db_xref="UniProtKB/Swiss-Prot:O31668" /translation="MAAKQERWRELAEVKRELAERDWFPATSGNLSIKVTDEPLTFLV TASGKDKRKETVEDFLLVDQNGEPAESGHSLKPSAETLLHTHLYNKTNAGCCLHVHTV NNNVISELYGDQKKITFKGQEIIKALGLWEENAEVTVPIIENPAHIPTLAALFAEEIS EDSGAVLIRNHGITAWGKTAFEAKRVLEAYEFLFSYHLKLKTLEHQLVK*" /label="mtnB CDS" gene 1275002..1275631 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /label="mtnB gene" CDS 1275646..1276182 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /EC_number="1.13.11.54" /EC_number="1.13.11.53" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acireductone dioxygenase (Ni2+ or Fe2+-requiring)" /protein_id="NP_389245.1" /db_xref="EnsemblGenomes-Gn:BSU13620" /db_xref="EnsemblGenomes-Tr:CAB13235" /db_xref="GOA:O31669" /db_xref="InterPro:IPR004313" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR023956" /db_xref="SubtiList:BG13285" /db_xref="UniProtKB/Swiss-Prot:O31669" /translation="MATIRIHDEANTTIENQEEVASFLDSQEVIYEQWDITRLPEHLS EKYDLTEEEKQQILDTFETEIKDISTRRGYKAQDVISLSDSNPKLDELLENFKREHHH TDDEVRFIVSGHGIFVIQGQDGTFFDVRLNPGDLISVPENIRHYFTLQEDRKVVAVRI FVTTEGWVPIYEKDSVNQ*" /label="mtnD CDS" gene 1275646..1276182 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /label="mtnD gene" S_feature complement(1276029..1276222) /Source="Nicolas_S_feature" /locus_tag="new_1429967_1430160_c" /HighExp="Lbstat, Cold, LBGstat, T0.30H, M9-stat, B60, ferm, T1.30H, LPhT, M0t90" /AntisenseName="mtnD" /AntisenseCor="-0.31139057410816301" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S487" downshifts 1276182 /Source="Nicolas_upshifts" /id="D749" /incds=0 /nref=179 /ntot=227 /MaxReadThrough="1.58976" /MaxDrop="6.10661" /score="35.4563733" /energy="-14.9" /TU="NA" /idTUdmin="U1103" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1276223..1276543) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389246.1" /db_xref="EnsemblGenomes-Gn:BSU13630" /db_xref="EnsemblGenomes-Tr:CAB13236" /db_xref="GOA:O31670" /db_xref="InterPro:IPR010652" /db_xref="SubtiList:BG13308" /db_xref="UniProtKB/Swiss-Prot:O31670" /translation="MKKKKAIMLGAAGGKAILKRKNRKKCIQHITTFFQMLRDWRNGD YPRSQVKTLLLLTAAILYIVMPLDIIPDVILGLGFIDDAAVLGLIWTLIKKELSQYEK WRLQ*" /label="ykvA CDS" gene complement(1276223..1276543) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /label="ykvA gene" downshifts complement(1276281) /Source="Nicolas_upshifts" /id="D750" /incds=0 /nref=5 /ntot=148 /MaxReadThrough="4.05831" /MaxDrop="2.74575" /score="18.5455371" /energy="-11.3" /TU="U1106" /idTUdmin="U1106" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(1276544..1276633) /Source="Nicolas_S_feature" /locus_tag="new_1430482_1430571_c" /HighExp="Lbstat, M9-stat, B60, T0.30H, LBGstat, M0t90, T1.0H, S2, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S488" promotor_-35 1276569..1276575 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1276590..1276608 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1276600 /Source="Nicolas_upshifts" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" S_feature 1276601..1276685 /Source="Nicolas_S_feature" /locus_tag="new_1430539_1430623" /HighExp="Etha, Gly, BC, Salt, Sw, B60, LoTm, M9-stat, LPhT, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S489" promotor_-10 complement(1276615..1276634) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1276632) /Source="Nicolas_upshifts" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1276649..1276652) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1276659..1276666 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1276681..1276700 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1276687..1276745 /Source="Nicolas_S_feature" /locus_tag="new_1430625_1430683" /HighExp="Etha, Gly, Sw, BC, LoTm, B36, T3.30H, Salt, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S490" upshifts 1276687 /Source="Nicolas_upshifts" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1276743) /Source="Nicolas_upshifts" /id="D751" /incds=0 /nref=3 /ntot=61 /MaxReadThrough="0.87927" /MaxDrop="3.53961" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1106" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1276746..1277003 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15057450, 15916600, 17001075, 19332814, 22524514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15057450, 15916600, 17001075, 19332814, 22524514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="negative regulatory phosphatase acting on Spo0A-P (sporulation)" /protein_id="NP_389247.1" /db_xref="EnsemblGenomes-Gn:BSU13640" /db_xref="EnsemblGenomes-Tr:CAB13237" /db_xref="GOA:P05043" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG10769" /db_xref="UniProtKB/Swiss-Prot:P05043" /translation="MGGSSEQERLLVSIDEKRKLMIDAARKQGFTGHDTIRHSQELDC LINEYHQLMQENEHSQGIQGLVKKLGLWPRRDVMPAYDANK*" /label="spo0E CDS" gene 1276746..1277003 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /label="spo0E gene" downshifts 1276997 /Source="Nicolas_upshifts" /id="D752" /incds=0 /nref=7 /ntot=169 /MaxReadThrough="4.39402" /MaxDrop="3.59614" /score="0.224700481" /energy="-5.9" /TU="U1105,U1107" /idTUdmin="U1105" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS 1277089..1277520 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative small membrane protein" /protein_id="NP_389248.1" /db_xref="EnsemblGenomes-Gn:BSU13650" /db_xref="EnsemblGenomes-Tr:CAB13238" /db_xref="GOA:P06630" /db_xref="SubtiList:BG10770" /db_xref="UniProtKB/Swiss-Prot:P06630" /translation="MKELAILITEMVNQFHDAFISLCGIFGIHLTDKEMHFWVIGIFG IFFFGVTHAVFTWLSKWSMTALSFIYTVTVIIVIVFAIEIQQKVTGRGNMEFLDATEG IKGFLVFFMFFLLLKMLLRFIKILFSGRPASKSNGNARSRR*" /label="eag CDS" gene 1277089..1277520 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /label="eag gene" CDS complement(1277548..1279068) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /EC_number="2.7.13.3" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine kinase phosphorylating Spo0A" /protein_id="NP_389249.1" /db_xref="EnsemblGenomes-Gn:BSU13660" /db_xref="EnsemblGenomes-Tr:CAB13239" /db_xref="GOA:O31671" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4JGO" /db_xref="PDB:4JGP" /db_xref="PDB:4JGQ" /db_xref="PDB:4JGR" /db_xref="SubtiList:BG13309" /db_xref="UniProtKB/Swiss-Prot:O31671" /translation="MLERCKLKILKGACGRVKLYIILVVIPAIVISFFVYEKEKDTIA AEHKQEASVLLNLHRNKINYLIGETMARMTSLSIAIDRPVDIKKMQSILEKTFDSEPR FSGLYFLNAKGDVTASTTELKTKVNLADRSFFIKAKETKKTVISDSYSSRITGQPIFT ICVPVLDSKRNVTDYLVAAIQIDYLKNLINLLSPDVYIEVVNQDGKMIFASGQASHAE DQKPVSGYLDDISWNMKVYPNPVTIEELSKSLVLPLSCIIVLLNILFILVLYYLLKRQ TQLERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIE QEIKRINQIVSEFLVLGKPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQYLTE QPLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQE MLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSAS*" /label="kinD CDS" gene complement(1277548..1279068) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /label="kinD gene" downshifts complement(1277560) /Source="Nicolas_upshifts" /id="D753" /incds=0 /nref=106 /ntot=227 /MaxReadThrough="0.62895" /MaxDrop="5.24795" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1109" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1278269..1278275 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1278289..1278300 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1278295 /Source="Nicolas_upshifts" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1279076..1279095) /Source="Nicolas_upshift_promotors" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1279097) /Source="Nicolas_upshifts" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1279195..1279202 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1279217..1279236 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1279219 /Source="Nicolas_upshifts" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="upshifts" CDS 1279261..1279698 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17725564, 17962296, 18282125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17725564, 17962296, 18282125; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family)" /protein_id="NP_389250.1" /db_xref="EnsemblGenomes-Gn:BSU13670" /db_xref="EnsemblGenomes-Tr:CAB13240" /db_xref="GOA:O31672" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13310" /db_xref="UniProtKB/Swiss-Prot:O31672" /translation="MTEKSLKLFIVLSRAYRSINDHMNKHIHKHGLNPTEFAVLELLY HKGDQPLQQIGDKILLASGSITYVVDKLEQKELLIRKASPTDRRVTFAQITEKGIGLL NDIFPDHAAEIDEMISVLSEEEVEMCTEMLKRVGLNAKQFHNK*" /label="mhqR CDS" gene 1279261..1279698 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /label="mhqR gene" downshifts 1279681 /Source="Nicolas_upshifts" /id="D754" /incds=0 /nref=210 /ntot=257 /MaxReadThrough="1.20686" /MaxDrop="5.47215" /score="1.59181784" /energy="-8.9" /TU="U1110" /idTUdmin="U1110" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1279738..1280523) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein B; MotB component of the H+-coupled stator flagellum complex" /protein_id="NP_389251.1" /db_xref="EnsemblGenomes-Gn:BSU13680" /db_xref="EnsemblGenomes-Tr:CAB13241" /db_xref="GOA:P28612" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10689" /db_xref="UniProtKB/Swiss-Prot:P28612" /translation="MARKKKKKHEDEHVDESWLVPYADILTLLLALFIVLYASSSIDA AKFQMLSKSFNEVFTGGTGVLDYSSVTPPENESDGIDEVKKEKEEKEKNKKEKEKAAD QEELENVKSQVEKFIKDKKLEHQLETKMTSEGLLITIKDSIFFDSGKATIRKEDVPLA KEISNLLVINPPRNIIISGHTDNMPIKNSEFQSNWHLSVMRAVNFMGLLIENPKLDAK VFSAKGYGEYKPVASNKTAEGRSKNRRVEVLILPRGAAETNEK*" /label="motB CDS" gene complement(1279738..1280523) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /label="motB gene" downshifts complement(1279757) /Source="Nicolas_upshifts" /id="D755" /incds=0 /nref=224 /ntot=246 /MaxReadThrough="3.05351" /MaxDrop="6.69306" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(1280219) /Source="Nicolas_upshifts" /id="D756" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="8.03566" /MaxDrop="4.69358" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1280495..1281307) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein A; MotA component of the H+-coupled stator flagellum complex" /protein_id="NP_389252.1" /db_xref="EnsemblGenomes-Gn:BSU13690" /db_xref="EnsemblGenomes-Tr:CAB13242" /db_xref="GOA:P28611" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10688" /db_xref="UniProtKB/Swiss-Prot:P28611" /translation="MDKTSLIGIILAFVALSVGMVLKGVSFSALANPAAILIIIAGTI SAVVIAFPTKEIKKVPTLFRVLFKENKQLTIEELIPMFSEWAQLARREGLLALEASIE DVDDAFLKNGLSMAVDGQSAEFIRDIMTEEVEAMEDRHQAGAAIFTQAGTYAPTLGVL GAVIGLIAALSHMDNTDELGHAISAAFVATLLGIFTGYVLWHPFANKLKRKSKQEVKL REVMIEGVLSVLEGQAPKVIEQKLLMYLPAKDRLKFAEQGEAQNGEKKEEEA*" /label="motA CDS" gene complement(1280495..1281307) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /label="motA gene" promotor_-10 complement(1281338..1281356) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1281354) /Source="Nicolas_upshifts" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1281370..1281377) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1281445..1281667) /Source="Nicolas_S_feature" /locus_tag="new_1435383_1435605_c" /HighExp="Diami, dia15, dia5, Heat, Etha, LPhT, H2O2, C30, G135, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.93062599999999995" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S491" downshifts complement(1281477) /Source="Nicolas_upshifts" /id="D757" /incds=0 /nref=5 /ntot=12 /MaxReadThrough="0.48394" /MaxDrop="4.60081" /score="30.9355071" /energy="-15.4" /TU="NA" /idTUdmin="U1112" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1281690..1283789) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease (class III stress gene)" /protein_id="NP_389253.1" /db_xref="EnsemblGenomes-Gn:BSU13700" /db_xref="EnsemblGenomes-Tr:CAB13243" /db_xref="GOA:O31673" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="SubtiList:BG12578" /db_xref="UniProtKB/Swiss-Prot:O31673" /translation="MRCQHCHQNEATIRLNMQINSVHKQMVLCETCYNELTRKPSMSM GPQSFGFPFEQAFQPKEQSAAKQSEKKGLLDELAQNITNGAKAGLIDPVIGRDDEVAR VIEILNRRNKNNPVLIGEPGVGKTAIAEGLALKIAEGDVPNKLKNKELYLLDVASLVA NTGIRGQFEERMKQLITELKERKNVILFIDEIHLLVGAGSAEGSMDAGNILKPALARG ELQVIGATTLKEYRQIEKDAALERRFQPVMVQEPSIEQAILILQGIKDKYEAYHGVTF SDEAIKACVTLSSRYIQDRHLPDKAIDLLDEAGSKANLLIDELNDEDAAERLTAIEAE KTKALEEENYELAAKLRDEELALEKKLNSSSAHTAVTVEAEHIQEIVEQKTGIPVGKL QADEQTKMKELEAKLHERVIGQEAAVQKVAKAVRRSRAGLKSKNRPVGSFLFVGPTGV GKTELSKTLADELFGTKDAIIRLDMSEYMEKHAVSKIIGSPPGYVGHEEAGQLTEKVR RNPYSIVLLDEIEKAHPDVQHMFLQIMEDGRLTDSQGRTVSFKDTVIIMTSNAGAGEK QTKVGFQSDDSVIEEQTLIDSLSMFFKPEFLNRFDSIIEFRSLEKEHLVKIVSLLLGE LEETLAERGISLNVTDEAKEKIAELGYHPSFGARPLRRTIQEWVEDEMTDLLLDNGEI TSFHVILEDDKIKVRAK*" /label="clpE CDS" gene complement(1281690..1283789) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /label="clpE gene" downshifts complement(1281712) /Source="Nicolas_upshifts" /id="D758" /incds=0 /nref=27 /ntot=132 /MaxReadThrough="4.1802" /MaxDrop="6.07862" /score="41.2563375" /energy="-13.6" /TU="U1112" /idTUdmin="U1112" /TUdmin="-239" /isTUend="FALSE" /label="downshifts" S_feature complement(1283790..1284040) /Source="Nicolas_S_feature" /locus_tag="new_1437728_1437978_c" /HighExp="dia5, Heat, Diami, LPhT, dia15, H2O2, HiTm, S2, Cold, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S492" promotor_no_box complement(1284000..1284100) /Source="Nicolas_upshift_promotors" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1284040) /Source="Nicolas_upshifts" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1284076..1284081 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1284091 /Source="Nicolas_upshifts" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1284097..1284115 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1284154..1285197 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389254.1" /db_xref="EnsemblGenomes-Gn:BSU13710" /db_xref="EnsemblGenomes-Tr:CAB13244" /db_xref="GOA:O31674" /db_xref="SubtiList:BG13311" /db_xref="UniProtKB/Swiss-Prot:O31674" /translation="MEQSKGSASQLAFVYVGTVVGAGFATGREIVEFFLKFGWFGFFG ILVSGGMFTLLGAKLMIISKRINAKSYQEMNIFLFGATAGRIINVFMLFVLLGVTSVM LSGAGALFEEQLGMSAQIGMLITIGLSLIVMTRGVKGIFGVNVFVVPLLIIFSMIVVA DSFIFSESRNAAQWVWPHRWDWLLSAVSYGALNLSLAQAVLVPLANEMSSEKVIKKGA LIGGTMLTIVLSASFLSLSTLPDVFLYDIPMAQVVYLFARSVHLIYLLIIFGEVFTSV IGNLYGLEKQVQSFLPVKSKYIFAAIMITAYITSQIGYGRLISTIYPLFGYVSLAFIG ALLCKKAPRRRSL*" /label="ykvI CDS" gene 1284154..1285197 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /label="ykvI gene" S_feature 1285198..1285289 /Source="Nicolas_S_feature" /locus_tag="new_1439136_1439227" /HighExp="S3, LoTm, S4, S5, BT, M9-stat, S6, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S493" promotor_-35 1285266..1285270 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1285287..1285306 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1285291 /Source="Nicolas_upshifts" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1285336..1285380 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /product="preQ1 riboswitch" /experiment="publication(s) with functional evidences, PMID:17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311; Product type n: RNA" /function="16.3: Control" /label="qswA RNA" gene 1285336..1285380 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /label="qswA gene" downshifts 1285357 /Source="Nicolas_upshifts" /id="D759" /incds=0 /nref=11 /ntot=17 /MaxReadThrough="7.29177" /MaxDrop="4.09959" /score="21.1398563" /energy="-9.5" /TU="U1114" /idTUdmin="U1113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1285402..1285509 /Source="Nicolas_S_feature" /locus_tag="new_1439340_1439447" /HighExp="Paraq, ferm, G180, LBGstat, Diami, H2O2, LPhT, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S494" CDS 1285510..1286169 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /EC_number="6.3.4.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14660578, 16199558, 17384645, 18491386, 19354300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14660578, 16199558, 17384645, 18491386, 19354300; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pre-queuosine 0 synthase" /protein_id="NP_389255.1" /db_xref="EnsemblGenomes-Gn:BSU13720" /db_xref="EnsemblGenomes-Tr:CAB13245" /db_xref="GOA:O31675" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018317" /db_xref="PDB:3BL5" /db_xref="SubtiList:BG13312" /db_xref="UniProtKB/Swiss-Prot:O31675" /translation="MKKEKAIVVFSGGQDSTTCLLWALKEFEEVETVTFHYNQRHSQE VEVAKSIAEKLGVKNHLLDMSLLNQLAPNALTRNDIEIEVKDGELPSTFVPGRNLVFL SFASILAYQIGARHIITGVCETDFSGYPDCRDEFVKSCNVTVNLAMEKPFVIHTPLMW LNKAETWKLADELGALDFVKNNTLTCYNGIIADGCGECPACHLRSKGYEEYMVMKGER A*" /label="queC CDS" gene 1285510..1286169 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /label="queC gene" CDS 1286162..1286611 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /EC_number="4.1.2.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 18259064, 19231875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 18259064, 19231875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-carboxy-5,6,7,8-tetrahydropterin synthase; queuosine biosynthesis" /protein_id="NP_389256.1" /db_xref="EnsemblGenomes-Gn:BSU13730" /db_xref="EnsemblGenomes-Tr:CAB13246" /db_xref="GOA:O31676" /db_xref="InterPro:IPR007115" /db_xref="SubtiList:BG13313" /db_xref="UniProtKB/Swiss-Prot:O31676" /translation="MHKLLSQIYPQAQHPYSFELNKDMHISAAHFIPRESAGACSRVH GHTYTVNITVAGDELDDSGFLVNFSVLKKLVHGNYDHTLLNDHEDFSQDDRYSLPTTE VVAKTIYDNVQAYLDTLENKPTCVQVFVRETPTSYCVYRPKKGGLNG*" /label="queD CDS" gene 1286162..1286611 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /label="queD gene" CDS 1286604..1287335 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /EC_number="4.3.99.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 19354300, 23194065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 19354300, 23194065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-carboxy-7-deazaguanine synthase" /protein_id="NP_389257.1" /db_xref="EnsemblGenomes-Gn:BSU13740" /db_xref="EnsemblGenomes-Tr:CAB13247" /db_xref="GOA:O31677" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR017742" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR024924" /db_xref="PDB:5TGS" /db_xref="PDB:5TH5" /db_xref="SubtiList:BG13314" /db_xref="UniProtKB/Swiss-Prot:O31677" /translation="MAKGIPVLEIFGPTIQGEGMVIGQKTMFVRTAGCDYSCSWCDSA FTWDGSAKKDIRWMTAEEIFAELKDIGGDAFSHVTISGGNPALLKQLDAFIELLKENN IRAALETQGTVYQDWFTLIDDLTISPKPPSSKMVTNFQKLDHILTSLQENDRQHAVSL KVVIFNDEDLEFAKTVHKRYPGIPFYLQVGNDDVHTTDDQSLIAHLLGKYEALVDKVA VDAELNLVRVLPQLHTLLWGNKRGV*" /label="queE CDS" gene 1286604..1287335 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /label="queE gene" CDS 1287353..1287850 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /EC_number="1.7.1.13" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent 7-cyano-7-deazaguanine reductase" /protein_id="NP_389258.1" /db_xref="EnsemblGenomes-Gn:BSU13750" /db_xref="EnsemblGenomes-Tr:CAB13248" /db_xref="GOA:O31678" /db_xref="InterPro:IPR016856" /db_xref="InterPro:IPR029500" /db_xref="PDB:4F8B" /db_xref="PDB:4FGC" /db_xref="PDB:5UDG" /db_xref="SubtiList:BG13315" /db_xref="UniProtKB/Swiss-Prot:O31678" /translation="MTTRKESELEGVTLLGNQGTNYLFEYAPDVLESFPNKHVNRDYF VKFNCPEFTSLCPKTGQPDFATIYISYIPDEKMVESKSLKLYLFSFRNHGDFHEDCMN IIMNDLIELMDPRYIEVWGKFTPRGGISIDPYTNYGKPGTKYEKMAEYRMMNHDLYPE TIDNR*" /label="queF CDS" gene 1287353..1287850 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /label="queF gene" S_feature 1287851..1288127 /Source="Nicolas_S_feature" /locus_tag="new_1441789_1442065" /HighExp="Paraq, ferm, LPhT, C30, G135, G180, LBGstat, Oxctl, G150, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S495" downshifts 1288085 /Source="Nicolas_upshifts" /id="D760" /incds=0 /nref=200 /ntot=247 /MaxReadThrough="1.17154" /MaxDrop="6.60953" /score="11.1883045" /energy="-7.8" /TU="NA" /idTUdmin="U1114" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1288095) /Source="Nicolas_upshifts" /id="D761" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.54726" /MaxDrop="2.16508" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature complement(1288164..1288408) /Source="Nicolas_S_feature" /locus_tag="new_1442102_1442346_c" /HighExp="Diami, dia5, LPhT, Etha, Salt, dia15, Heat, HiTm, C30, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15795400000000001" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S496" downshifts complement(1288205) /Source="Nicolas_upshifts" /id="D762" /incds=0 /nref=47 /ntot=193 /MaxReadThrough="2.13712" /MaxDrop="5.08206" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1288409..1288765) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HGT island)" /protein_id="NP_389259.1" /db_xref="EnsemblGenomes-Gn:BSU13760" /db_xref="EnsemblGenomes-Tr:CAB13249" /db_xref="GOA:O31679" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13316" /db_xref="UniProtKB/Swiss-Prot:O31679" /translation="MKKFSCGFEVTKEVIGGKWKGLVLYFLMNGPKRTSELKRIIPNI TQKMLIQTLRELEASGLVSRKMYNQVPPKVEYSSTELGESLKPILQELCQWGGYYAEQ EYAEGEYEIVQPEQLS*" /label="ykvN CDS" gene complement(1288409..1288765) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /label="ykvN gene" misc_feature complement(1288796..1288815) /Source="Nicolas_upshift_promotors" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1288813) /Source="Nicolas_upshifts" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1288850..1288868 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1288855 /Source="Nicolas_upshifts" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="upshifts" CDS 1288934..1289680 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018, 26494135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (HGT island)" /protein_id="NP_389260.1" /db_xref="EnsemblGenomes-Gn:BSU13770" /db_xref="EnsemblGenomes-Tr:CAB13250" /db_xref="GOA:O31680" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13317" /db_xref="UniProtKB/Swiss-Prot:O31680" /translation="MGKFEGKIALVTGGTSGIGLATAQKFVNEGAYVYITGRRQNELD KAVNQIGKNVTGVQGDISKLEDLDKLYDIIKQEKGKLDILFANAGIGNFLPLGEITEE QVDRTFDINVKGTIFTVQKALSLFPDKVGSIIVTGSTAGSIGNPAFSVYGASKAALRA LVRNWILDLKGTEIRVNVVSPGGILTPAYDELFGDALEEVLENSRNTVPAGKVGTPEE VANAVSFLASDESSYLTGVELFVDGGLAQV*" /label="ykvO CDS" gene 1288934..1289680 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /label="ykvO gene" downshifts 1289735 /Source="Nicolas_upshifts" /id="D763" /incds=0 /nref=19 /ntot=146 /MaxReadThrough="0.723690000000001" /MaxDrop="4.37163" /score="1.34631843" /energy="-9.1" /TU="NA" /idTUdmin="U1116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1290083..1290091 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1290105..1290124 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1290109 /Source="Nicolas_upshifts" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="upshifts" CDS 1290161..1291360 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11011148, 16683018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16683018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein (HGT island)" /protein_id="NP_389261.1" /db_xref="EnsemblGenomes-Gn:BSU13780" /db_xref="EnsemblGenomes-Tr:CAB13251" /db_xref="GOA:O31681" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13318" /db_xref="UniProtKB/Swiss-Prot:O31681" /translation="MKILFLESHPMWLYGLPNGFREAGHTVMISGPVSRENITEMIDE FKPDLIVSMGWTPEHSREKQAWIRNATKKVNIPLVYWATEDPLHTQNFTIPLIKKMKP DFVFTVTPSLCKTYESMGIKAAHLDFAFHESIHHQIKPLAKYSCDIAVVANAYPNFLE EHPEVFRSSSLKTLIRPLIRKGIRIDFWGRNWEKMSKYIGREIPRNWIHGYLDYTEAY KVYSSAKIIIGLQNCESQLTQRTYEILGSGGFLLTSDTPAVRGKFKPGRDLIVSSSPK ETLEKVKYYLNHDSERKKIQINGKKAVKNDSYRHRAERMLEVLKSRGIIRNLGETIHY VDVLKEKYVIHHVTPGETLSIIASKYNVSLQQLMELNHFKSDQIYAGQIIKIREKLFR NINNKLF*" /label="ykvP CDS" gene 1290161..1291360 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /label="ykvP gene" promotor_-35 1290243..1290249 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1290264..1290282 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1290270 /Source="Nicolas_upshifts" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1291329..1291331 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1291351..1291369 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1291363 /Source="Nicolas_upshifts" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1291376..1291603 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative peptidoglycan binding protein" /protein_id="YP_003097719.1" /db_xref="EnsemblGenomes-Gn:BSU13789" /db_xref="EnsemblGenomes-Tr:CAX52610" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="UniProtKB/Swiss-Prot:C0H403" /translation="MKGKIPKIRNQANKVKRTPRYMEFPVTYEVYHVESGDTLWTIAK SFEIPVQQLMNLNKLSSDRIYPGQIIKIRER*" /label="ykzQ CDS" gene 1291376..1291603 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /label="ykzQ gene" misc_feature complement(1291453..1291472) /Source="Nicolas_upshift_promotors" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1291461) /Source="Nicolas_upshifts" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1291604..1291699 /Source="Nicolas_S_feature" /locus_tag="new_1445542_1445637" /HighExp="BT, S8, B36, S7, Etha, S6, G/S, LBGstat, Pyr, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigK" /TUshortPSig="0.602, 0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S497" CDS 1291700..1292398 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /EC_number="3.2.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative sporulation-specific glycosylase (HGT island)" /db_xref="EnsemblGenomes-Gn:BSU13790" /db_xref="EnsemblGenomes-Tr:CAB13252" /db_xref="GOA:O31682" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAB13252.1" /db_xref="SubtiList:BG13319" /db_xref="UniProtKB/Swiss-Prot:O31682" /translation="MFQMSYYYSGLGWDFIQHVDQTNGVLNVVSPDFFYIRKDGSLLL RSANPDVIKALHRRKLKVVPFLSNHWDQDLGRFALMNRVLLAKQISHAIEELDLDGVN IDIENLTEKDRNLFTDFIRLVRKSIPRHKEVSVAVAANPFGWTKGWHGSYDYEYLAKY ADYLMVMAYDESRLAGPTASVGWVEKSIQYVLTQKISPQKLVLGLPFYGRCWMEGQSA SQAIPLYLVVSKKA*" /label="ykvQ CDS" gene 1291700..1292398 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /pseudo /label="ykvQ gene" S_feature complement(1292351..1293177) /Source="Nicolas_S_feature" /locus_tag="new_1446289_1447115_c" /HighExp="H2O2, M40t90, S8, M40t45, LPhT, Sw, Cold, LBGstat, C30, dia15" /AntisenseName="ykzR" /AntisenseCor="0.170402182980955" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="0.38670900000000002" /TUshortSig="SigA" /TUshortPSig="0.986" /TUlongSig="NA" /TUlongPSig="NA" /label="S498" CDS 1292379..1292630 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative spore-specific glycosyl hydrolase" /db_xref="EnsemblGenomes-Gn:BSU13799" /db_xref="EnsemblGenomes-Tr:CAX52611" /db_xref="GOA:C0H404" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAX52611.1" /db_xref="UniProtKB/Swiss-Prot:C0H404" /translation="MLVKRHSGTIIFDTKSQSPKAIFTVNHDKKGPLPSGTYTLWFEN EQSLRAKIKLAQKYNLKGLGSWSLGQEDASVWNTVFKNI*" /label="ykzR CDS" gene 1292379..1292630 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /pseudo /label="ykzR gene" misc_feature 1292880..1292895 /Source="Nicolas_upshift_promotors" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1292903..1293114 /Source="Nicolas_S_feature" /locus_tag="new_1446841_1447052" /HighExp="Diami, S8, dia15, G180, HPh, C30, Paraq, H2O2, Salt, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.516" /TUlongSig="NA" /TUlongPSig="NA" /label="S499" upshifts 1292903 /Source="Nicolas_upshifts" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="upshifts" downshifts 1293079 /Source="Nicolas_upshifts" /id="D764" /incds=0 /nref=2 /ntot=72 /MaxReadThrough="2.59168" /MaxDrop="2.74537" /score="-4.38958816" /energy="-9" /TU="NA" /idTUdmin="U1121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1293166..1293185) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1293188) /Source="Nicolas_upshifts" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1293201..1293208) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1293253..1293260 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1293275..1293294 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1293277 /Source="Nicolas_upshifts" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="upshifts" CDS 1293313..1293603 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="NP_389263.1" /db_xref="EnsemblGenomes-Gn:BSU13800" /db_xref="EnsemblGenomes-Tr:CAB13253" /db_xref="InterPro:IPR021596" /db_xref="InterPro:IPR023105" /db_xref="PDB:2JN9" /db_xref="SubtiList:BG13320" /db_xref="UniProtKB/Swiss-Prot:O31683" /translation="MKTLRLNNVTLEMAAYQEESEPKRKIAFTLNVTSETYHDIAVLL YEKTFNVEVPERDLAFRGEMTNYSTSLTNLYEPGAVSEFYIEITEIDKNADS*" /label="ykvR CDS" gene 1293313..1293603 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /label="ykvR gene" S_feature complement(1293640..1293723) /Source="Nicolas_S_feature" /locus_tag="new_1447578_1447661_c" /HighExp="Etha, dia5, Salt, SMMPr, Lbtran, dia15, Heat, S4, HiOs, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S500" downshifts complement(1293683) /Source="Nicolas_upshifts" /id="D765" /incds=0 /nref=216 /ntot=257 /MaxReadThrough="2.80569" /MaxDrop="6.83857" /score="21.3524751" /energy="-9.9" /TU="U1124" /idTUdmin="U1126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1293724..1293909) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (HGT island)" /protein_id="NP_389264.2" /db_xref="EnsemblGenomes-Gn:BSU13810" /db_xref="EnsemblGenomes-Tr:CAB13254" /db_xref="InterPro:IPR018690" /db_xref="SubtiList:BG13321" /db_xref="UniProtKB/Swiss-Prot:O31684" /translation="MKIAKVGNVIEFKNGLTGVVEKVNENSVIVDVTIMDNYRDLELD SLTVVNHKNYKIIRDSY*" /label="ykvS CDS" gene complement(1293724..1293909) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /label="ykvS gene" promotor_-10 complement(1293942..1293961) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1293953) /Source="Nicolas_upshifts" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1293955..1294299) /Source="Nicolas_S_feature" /locus_tag="new_1447893_1448237_c" /HighExp="S4, S8, S6, S5, S3, T5.0H, LoTm, S7, T4.0H, BT" /AntisenseName="ykzS" /AntisenseCor="-0.65556958045860303" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S501" promotor_-35 complement(1293975..1293982) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1294008..1294013 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1294029..1294048 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1294036 /Source="Nicolas_upshifts" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="upshifts" CDS 1294075..1294269 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="YP_003097721.1" /db_xref="EnsemblGenomes-Gn:BSU13819" /db_xref="EnsemblGenomes-Tr:CAX52612" /db_xref="UniProtKB/Swiss-Prot:C0H405" /translation="MRPEEITEMIEQLRTGAINELRVQKEHFLDFRAVLSKQDDFKHF RGIAQQGGDVIFQYLEQPRS*" /label="ykzS CDS" gene 1294075..1294269 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /label="ykzS gene" downshifts 1294245 /Source="Nicolas_upshifts" /id="D766" /incds=0 /nref=6 /ntot=124 /MaxReadThrough="3.66738" /MaxDrop="3.03929" /score="5.82604583" /energy="-10.6" /TU="U1125" /idTUdmin="U1123" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1294290..1294308) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1294306) /Source="Nicolas_upshifts" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1294325..1294330) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1294568..1295194 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12177332, 12950927, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall hydrolase related to spore cortex-lytic enzymes" /protein_id="NP_389265.1" /db_xref="EnsemblGenomes-Gn:BSU13820" /db_xref="EnsemblGenomes-Tr:CAB13255" /db_xref="GOA:O31685" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG13322" /db_xref="UniProtKB/Swiss-Prot:O31685" /translation="MTTKFTALAVFLLCFMPAAKIEHTQASLLSAKKTKHEEAKWLTH IDRNTNESFPSLSADKDKKIKPIKLSAHTEKKEKDKPDKTNDEKETYTQSEKELLSRL VHAEAKGESYKGKVAVASVVLNRTEKKGFPDTIRGVIYQKNAFEPVANGSINQKPDKE SIEAAEEALSSKNRETDAIFFYNPKTASDNWIRSRKIVEKIGRHVFAV*" /label="ykvT CDS" gene 1294568..1295194 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /label="ykvT gene" downshifts 1295125 /Source="Nicolas_upshifts" /id="D767" /incds=1 /nref=1 /ntot=17 /MaxReadThrough="0.932830000000001" /MaxDrop="1.92264" /score="9.80914166" /energy="-11.9" /TU="NA" /idTUdmin="U1125" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1295251..1295256 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1295263 /Source="Nicolas_upshifts" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1295272..1295290 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1295312..1296649 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15686839, 15849754, 16850406, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15686839, 15849754, 16850406, 19648239; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore membrane protein involved in germination" /protein_id="NP_389266.1" /db_xref="EnsemblGenomes-Gn:BSU13830" /db_xref="EnsemblGenomes-Tr:CAB13256" /db_xref="GOA:O31686" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="SubtiList:BG13323" /db_xref="UniProtKB/Swiss-Prot:O31686" /translation="MNRFVKGIILLSIAAFFAECLEFVVNMILARELGEHGMGLYMSI LPTIFLIIVIASLELPISISKFIAESNPKLHESMLRHAFRMTAIFTAFSTAAASIALP FIPVFDTYHPFIKGIVIGLIPVVAFTSIARGYFMGVQKMGKIAIANVLKKIIQLLCLF LFFQWYSFELDMAVLISLFVLVVSDVVVLVYLYSQFIMARRALSGQQHIHLRGKDVRK RLLAVSIPTTGLRIFHAVVNAIEPFLVKGALLAAGVAGTAAIDQYGMLAGVAVTIGSF PAFIAHSLMVVMIPSISEAYALSQYDIVLKRLKQSIFITLGYGIPAVWVMFQFAGPLT HLFFHSPEAQYYLQLLWPYFLFHLFVMPLQACLIGMGFVKEAFYHNVWSHIVALSMMY VLGSMENLQMLGIILGMNTGMILLTSLHYATICKALKVSVFLTGGTRTPRIEG*" /label="ykvU CDS" gene 1295312..1296649 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /label="ykvU gene" CDS 1296700..1297197 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15292147, 15322369, 15342593, 19144642, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292147, 15322369, 15342593, 19144642, 28383125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific thiol-disulfide oxidoreductase (SpoVD maturation)" /protein_id="NP_389267.1" /db_xref="EnsemblGenomes-Gn:BSU13840" /db_xref="EnsemblGenomes-Tr:CAB13257" /db_xref="GOA:O31687" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:3ERW" /db_xref="SubtiList:BG13324" /db_xref="UniProtKB/Swiss-Prot:O31687" /translation="MLTKRLLTIYIMLLGLIAWFPGAAQAEEKQPAVPAVFLMKTIEG EDISIPNKGQKTILHFWTSWCPPCKKELPQFQSFYDAHPSDSVKLVTVNLVNSEQNQQ VVEDFIKANKLTFPIVLDSKGELMKEYHIITIPTSFLLNEKGEIEKTKIGPMTAEQLK EWTEE*" /label="stoA CDS" gene 1296700..1297197 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /label="stoA gene" promotor_-35 1297046..1297052 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1297061 /Source="Nicolas_upshifts" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1297067..1297085 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1297171 /Source="Nicolas_upshifts" /id="D768" /incds=0 /nref=36 /ntot=164 /MaxReadThrough="1.89069" /MaxDrop="4.34947" /score="14.1388498" /energy="-11.3" /TU="NA" /idTUdmin="U1127" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1297292..1297298 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1297309..1297328 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1297321 /Source="Nicolas_upshifts" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1297325..1297432 /Source="Nicolas_S_feature" /locus_tag="new_1451263_1451370" /HighExp="LBGstat, C90, Lbstat, BC, Cold, T0.30H, Etha, Lbtran, LBGtran, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S502" CDS 1297433..1299346 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029044, 12180919, 15802251, 21813502, 26261021, 26566138" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12180919, 15802251, 21813502, 26261021, 26566138; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Fe(II) efflux transporter possibly involved in copper(II) uptake" /protein_id="NP_389268.1" /db_xref="EnsemblGenomes-Gn:BSU13850" /db_xref="EnsemblGenomes-Tr:CAB13258" /db_xref="GOA:O31688" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13325" /db_xref="UniProtKB/Swiss-Prot:O31688" /translation="MNEQVIVQRDPHEPLKTDKREKNWAQHAELIAALVSGALILAGW LLSGYQVLSIILFLLAFVIGGFAKAKEGIEETLESKTLNVELLMIFAAIGSALIGYWA EGAILIFIFSLSGALETYTMNKSSRDLTSLMQLEPEEATLMVNGETKRVPVSDLQAGD MIVIKPGERVAADGIIESGSTSLDESALTGESMPVEKNTGDTVFTGTVNRNGSLTVRV TKANEDSLFRKIIKLVESAQNSVSPAQAFIERFENAYVKGVLIAVALLLFVPHFALGW SWSETFYRAMVFMVVASPCALVASIMPAALSLISNGARNGMLVKGSVFLEQLGSVQMI AFDKTGTVTKGQPAVETIRIAEGFSEAEVLEAVYAIETQSSHPLAQAITAYAESRGVN QSGYISIEETSGFGVMAEVSGAKWKVGKAGFIGEEMAAQFMKQTASDVIQSGHTIVFV KKDDQIAGCIALKDQIRPEAKEVMEELNRLGIKTAMLTGDHEDTAQAIAKEAGMTTVV AECLPDQKVNEIKRLKEEFGTIAMVGDGINDAPALKAADVGIAMGGGTDVALETADMV LMKNDLKKLVNMCRLSRKMNRIIKQNIVFSLAVICLLICANFLQAMELPFGVIGHEGS TILVILNGLRLLK*" /label="pfeT CDS" gene 1297433..1299346 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /label="pfeT gene" promotor_-10 complement(1297582..1297601) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1297599) /Source="Nicolas_upshifts" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1297614..1297623) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1297750..1297769) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1297775) /Source="Nicolas_upshifts" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1297783..1297789) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1299327 /Source="Nicolas_upshifts" /id="D769" /incds=0 /nref=62 /ntot=148 /MaxReadThrough="2.05978" /MaxDrop="6.90668" /score="30.2111295" /energy="-18" /TU="NA" /idTUdmin="U1129" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1299403) /Source="Nicolas_upshifts" /id="D770" /incds=0 /nref=74 /ntot=208 /MaxReadThrough="0.83751" /MaxDrop="4.23141" /score="34.2342147" /energy="-18" /TU="NA" /idTUdmin="U1132" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1299614..1299633) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1299623) /Source="Nicolas_upshifts" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1299647..1299654) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1299698..1299717 /Source="Nicolas_upshift_promotors" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1299708 /Source="Nicolas_upshifts" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="upshifts" CDS 1299753..1300844 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7770058, 23144141" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7770058, 23144141; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Xaa-Pro Xaa-Pro-Xaa di-tri-peptidase used in osmoprotection" /protein_id="NP_389269.1" /db_xref="EnsemblGenomes-Gn:BSU13860" /db_xref="EnsemblGenomes-Tr:CAB13259" /db_xref="GOA:O31689" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG13326" /db_xref="UniProtKB/Swiss-Prot:O31689" /translation="MNRIQRVSSWLKEAGHTAAFIHTKENVFYLTGFYTEPHERLMGL FIFQEEEPFFVCPGMEAGQARNAGWNHEIIGYADHENPWELIEKALKKRNISIHMLAV EKDSISLSRAEQLKHATGGAQFVSAEETLNQFRLIKDDNEIRLLKEAAKLADYGVEVG TAALREGISEVEVLAQIEYELKKKGIQGMSFSTMVLFGEKSGQPHGNPGTATLKKGDF VLFDLGVILDGYCSDITRTFAYKTINPKQEAIYETVLQAEKAAIEASKPGVRIGDLDL TARGIIEKAGYGDYFPHRLGHGLGISVHEYPSMSQANDTLLQEGMVYTIEPGIYVPEI GGVRIEDDVHVTKDGAVALTQYPKDLIIL*" /label="papB CDS" gene 1299753..1300844 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /label="papB gene" downshifts 1300493 /Source="Nicolas_upshifts" /id="D771" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.10599" /MaxDrop="5.06339" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts 1300823 /Source="Nicolas_upshifts" /id="D772" /incds=0 /nref=2 /ntot=52 /MaxReadThrough="5.66039" /MaxDrop="2.56719" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" S_feature complement(1300857..1301075) /Source="Nicolas_S_feature" /locus_tag="new_1454795_1455013_c" /HighExp="B60, B36, C30, G135, LBGstat, S8, Lbstat, C90, Etha, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.92748200000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S503" S_feature 1300868..1301125 /Source="Nicolas_S_feature" /locus_tag="new_1454806_1455063" /HighExp="dia15, dia5, Etha, M0t90, M40t90, Lbstat, H2O2, G150, Mt0, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S504" promotor_-10 complement(1301062..1301081) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1301075) /Source="Nicolas_upshifts" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1301097..1301104) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1301126..1302091 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LacI family)" /protein_id="NP_389270.1" /db_xref="EnsemblGenomes-Gn:BSU13870" /db_xref="EnsemblGenomes-Tr:CAB13260" /db_xref="GOA:O31690" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13327" /db_xref="UniProtKB/Swiss-Prot:O31690" /translation="MANIKDIAEKAGVSVTTVSRVINNHPYVSEDKRKRVFEAMESLE YTRNIHAVHLSKGFSNMIGVVLPTVNLPYFAELIAGIADAAAESGVHLSLFQTNYEVQ KEIFALSQLKQRQVDGLIFCSKALADEKLMEWEGPILLCQNSDNARFPTISIPHQEAF RNGLDYLIAKGHKKIAICLARKKGMNSHFRIKAYKEALEEIGEAFREDWVIEKAITIN DGKALFHKWNTWKEKPTAIFVANDQVSAGLFLEAKNQRVSVPDELAILSVDNHEISQA LGITTIDIQTREMGKQAFAILEKRIQGQPIERKVLDYRLIERSTV*" /label="ykvZ CDS" gene 1301126..1302091 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /label="ykvZ gene" promotor_-35 1302109..1302116 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-35" promotor_-10 1302131..1302150 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-10" upshifts 1302143 /Source="Nicolas_upshifts" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="upshifts" CDS 1302154..1303020 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10974121, 14527945, 15155854, 17074746, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974121, 14527945, 15155854, 17074746, 22750856; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_389271.2" /db_xref="EnsemblGenomes-Gn:BSU13880" /db_xref="EnsemblGenomes-Tr:CAB13261" /db_xref="GOA:O31691" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:3GWH" /db_xref="PDB:3RIO" /db_xref="PDB:3UFE" /db_xref="SubtiList:BG12593" /db_xref="UniProtKB/Swiss-Prot:O31691" /translation="MTKELRIVNGSFTVKKVLNNNVLIASHHKYSEVVLIGKGIGFGK KQDDVIEDKGYDKMFILKDEKEQKQFKKLLDYVDEKLVDISNDVIYHISNRTNHSLNE HIHIALTDHIAFAIKRQQQGFDMKNPFLMETQSLYPEEYQIAKEVIDMINEKAGLCLP EGEIGFIALHIHSALTNRPLSEVNQHSQLMAQLVEVIEDSFQMKVNKESVNYLRLIRH IRFTIERIKKEEPTKEPEKLMLLLKNEYPLCYNTAWKLIKILQQTLKKPVHEAEAVYL TLHLYRLTNKIS*" /label="glcT CDS" gene 1302154..1303020 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /label="glcT gene" promotor_-35 1302875..1302879 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1302896..1302915 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1302904 /Source="Nicolas_upshifts" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" downshifts 1303022 /Source="Nicolas_upshifts" /id="D773" /incds=0 /nref=1 /ntot=30 /MaxReadThrough="9.01653" /MaxDrop="3.09921" /score="-5.18621526" /energy="-6.2" /TU="U1133,U1135,U1136" /idTUdmin="U1135" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_RNA 1303067..1303218 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /product="riboswitch regulating ptsGHI expression via GlcTbinding" /experiment="publication(s) with functional evidences, PMID:15155854, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15155854, 22750856; Product type n: RNA" /label="gswA RNA" S_feature 1303067..1303218 /Source="Nicolas_S_feature" /locus_tag="new_1457005_1457156" /HighExp="LBGexp, G150, C30, G135, G180, MG 90, dia0, Lbexp, dia15, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.988, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S505" gene 1303067..1303218 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /label="gswA gene" promotor_-35 1303196..1303202 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1303216..1303227 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1303220 /Source="Nicolas_upshifts" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="upshifts" CDS 1303249..1305348 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /EC_number="2.7.1.199" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucose-specificenzyme IICBA component" /protein_id="NP_389272.1" /db_xref="EnsemblGenomes-Gn:BSU13890" /db_xref="EnsemblGenomes-Tr:CAB13262" /db_xref="GOA:P20166" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="PDB:1AX3" /db_xref="PDB:1GPR" /db_xref="SubtiList:BG10198" /db_xref="UniProtKB/Swiss-Prot:P20166" /translation="MFKALFGVLQKIGRALMLPVAILPAAGILLAIGNAMQNKDMIQV LHFLSNDNVQLVAGVMESAGQIVFDNLPLLFAVGVAIGLANGDGVAGIAAIIGYLVMN VSMSAVLLANGTIPSDSVERAKFFTENHPAYVNMLGIPTLATGVFGGIIVGVLAALLF NRFYTIELPQYLGFFAGKRFVPIVTSISALILGLIMLVIWPPIQHGLNAFSTGLVEAN PTLAAFIFGVIERSLIPFGLHHIFYSPFWYEFFSYKSAAGEIIRGDQRIFMAQIKDGV QLTAGTFMTGKYPFMMFGLPAAALAIYHEAKPQNKKLVAGIMGSAALTSFLTGITEPL EFSFLFVAPVLFAIHCLFAGLSFMVMQLLNVKIGMTFSGGLIDYFLFGILPNRTAWWL VIPVGLGLAVIYYFGFRFAIRKFNLKTPGREDAAEETAAPGKTGEAGDLPYEILQAMG DQENIKHLDACITRLRVTVNDQKKVDKDRLKQLGASGVLEVGNNIQAIFGPRSDGLKT QMQDIIAGRKPRPEPKTSAQEEVGQQVEEVIAEPLQNEIGEEVFVSPITGEIHPITDV PDQVFSGKMMGDGFAILPSEGIVVSPVRGKILNVFPTKHAIGLQSDGGREILIHFGID TVSLKGEGFTSFVSEGDRVEPGQKLLEVDLDAVKPNVPSLMTPIVFTNLAEGETVSIK ASGSVNREQEDIVKIEK*" /label="ptsG CDS" gene 1303249..1305348 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /label="ptsG gene" promotor_-35 1305366..1305370 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1305386..1305405 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1305397 /Source="Nicolas_upshifts" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1305446..1305712 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="histidine-containing phosphocarrier protein of the phosphotransferase system (PTS) (HPr protein)" /protein_id="NP_389273.1" /db_xref="EnsemblGenomes-Gn:BSU13900" /db_xref="EnsemblGenomes-Tr:CAB13263" /db_xref="GOA:P08877" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR001020" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1JEM" /db_xref="PDB:1KKL" /db_xref="PDB:1KKM" /db_xref="PDB:1SPH" /db_xref="PDB:2FEP" /db_xref="PDB:2HID" /db_xref="PDB:2HPR" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10200" /db_xref="UniProtKB/Swiss-Prot:P08877" /translation="MAQKTFKVTADSGIHARPATVLVQTASKYDADVNLEYNGKTVNL KSIMGVMSLGIAKGAEITISASGADENDALNALEETMKSEGLGE*" /label="ptsH CDS" gene 1305446..1305712 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /label="ptsH gene" CDS 1305712..1307424 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /EC_number="2.7.3.9" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106335, 11902727, 15155854, 15670601, 25355936, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106335, 11902727, 15155854, 15670601, 25355936, 26159071; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) enzyme I" /protein_id="NP_389274.2" /db_xref="EnsemblGenomes-Gn:BSU13910" /db_xref="EnsemblGenomes-Tr:CAB13264" /db_xref="GOA:P08838" /db_xref="InterPro:IPR000121" /db_xref="InterPro:IPR006318" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR008731" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018274" /db_xref="InterPro:IPR023151" /db_xref="InterPro:IPR024692" /db_xref="InterPro:IPR036618" /db_xref="SubtiList:BG10201" /db_xref="UniProtKB/Swiss-Prot:P08838" /translation="MQELKGIGASAGIAIAKAYRLEEPDLTVEKKNISDSEAEVSRFD EAIARSKEELEKIKEHALKELGQDKADIFSAHLLVLSDPELLNPVKEKISTDSVNAEF ALKETSSMFVTMFESMDNEYMKERAADIRDVTKRVTGHLLGVEIPNPSMISEEVIIVA EDLTPSDTAQLNREFVKGFTTDIGGRTSHSAIMARSLEIPAVVGTKAATGTIQNGVTV IVDGINGDVIIDPSAETVKEYEEKHNAYLAQKAEWAKLVNEPTVSKDGHHVELAANIG TPDDVKGVLENGGEAVGLYRTEFLYMGRDQLPTEDEQFDAYKTVLERMEGKSVVVRTL DIGGDKELPYLQLPKEMNPFLGYRAIRLCLEEQEIFRTQLRALLRASTYGNLKIMFPM IATVNEFKEAKAILLEEKEKLVKAGQAVSDDIEVGMMVEIPSTAVIADQFAKEVDFFS IGTNDLIQYTMAADRMNERVSYLYQPYNPAILRLITLVIEAAHKEGKWVGMCGEMAGD EIAIPILLGLGLDEFSMSATSILPARTQISKLSKQEAESFKEKILSMSTTEEVVAFVK ETFK*" /label="ptsI CDS" gene 1305712..1307424 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /label="ptsI gene" downshifts 1307411 /Source="Nicolas_upshifts" /id="D774" /incds=0 /nref=116 /ntot=277 /MaxReadThrough="5.0255" /MaxDrop="5.64321" /score="21.2608168" /energy="-12.3" /TU="U1136,U1138" /idTUdmin="U1133" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-35 1307464..1307470 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1307485..1307496 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1307488 /Source="Nicolas_upshifts" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1307515..1307754 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9009064, 9323362, 10629212" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9009064, 9323362, 10629212; Product type r: regulator" /codon_start=1 /transl_table=11 /product="TRAP-like transcriptional negative regulator of spore photoproduct lyase" /protein_id="NP_389275.1" /db_xref="EnsemblGenomes-Gn:BSU13920" /db_xref="EnsemblGenomes-Tr:CAB13265" /db_xref="GOA:P37955" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG10202" /db_xref="UniProtKB/Swiss-Prot:P37955" /translation="MSNQFNAGDTVYVIYRNPHAANVAHIKEAEIVHHPYHEGELSLF IYETYHPFAEDDAVFASYEEAKSLYKELFDIDPYE*" /label="splA CDS" gene 1307515..1307754 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /label="splA gene" S_feature complement(1307535..1308874) /Source="Nicolas_S_feature" /locus_tag="new_1461473_1462812_c" /HighExp="T4.0H, T3.30H, T3.0H, S3, S1, T2.0H, T2.30H, S2, T5.0H, S4" /AntisenseName="splB" /AntisenseCor="-0.193138593783996" /AntisenseRegPval="-2.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S506" CDS 1307832..1308860 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /EC_number="4.1.99.14" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore photoproduct (thymine dimer) lyase" /protein_id="NP_389276.1" /db_xref="EnsemblGenomes-Gn:BSU13930" /db_xref="EnsemblGenomes-Tr:CAB13266" /db_xref="GOA:P37956" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023897" /db_xref="InterPro:IPR034560" /db_xref="SubtiList:BG10203" /db_xref="UniProtKB/Swiss-Prot:P37956" /translation="MQNPFVPQLVYIEPRALEYPLGQELQDKFENMGIEIRETTSHNQ VRNIPGKNHLQQYRNAKSTLVIGVRKTLKFDSSKPSAEYAIPFATGCMGHCHYCYLQT TMGSKPYIRTYVNVEEILDQADKYMKERAPEFTRFEASCTSDIVGIDHLTHTLKRAIE HFGQSDLGKLRFVTKFHHVDHLLDAKHNGKTRFRFSINADYVIKNFEPGTSPLDKRIE AAVKVAKAGYPLGFIVAPIYIHEGWEEGYRHLFEKLDAALPQDVRHDITFELIQHRFT KPAKRVIEKNYPKTKLELDEEKRRYKWGRYGIGKYIYQKDEEHALREALESYIDTFFP NAKIEYFT*" /label="splB CDS" gene 1307832..1308860 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /label="splB gene" downshifts 1308830 /Source="Nicolas_upshifts" /id="D775" /incds=0 /nref=5 /ntot=113 /MaxReadThrough="0.352" /MaxDrop="3.95383" /score="15.9223136" /energy="-13.2" /TU="NA" /idTUdmin="U1136" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1308875..1309555) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase / amidohydrolase" /protein_id="NP_389277.2" /db_xref="EnsemblGenomes-Gn:BSU13940" /db_xref="EnsemblGenomes-Tr:CAB13267" /db_xref="GOA:Q796K9" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12252" /db_xref="UniProtKB/Swiss-Prot:Q796K9" /translation="MIILKQMYVHDGRKFEALTIRNYTETDIERLISLQEECFPPPFP QELLWSEDQLASHIKTFPEGALCALINGRIIGSMTALIVQFEPDSPDHTWAQATDNGS IKNHEPHGNTLYVVDISVSPHYRKLGIGKWLMNTMYELTVDKRLERLLGGGRIPLYYK YAHEISAVQYVEDVMEGRKNDPVLSFLLRCGRSPIRVVSNYLEDKESLNYGVLMEWKN VFYKKASC*" /label="ykwB CDS" gene complement(1308875..1309555) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /label="ykwB gene" promotor_-10 complement(1309565..1309584) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1309588) /Source="Nicolas_upshifts" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1309599..1309606) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1309640..1309647 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-35" promotor_-10 1309661..1309679 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-10" upshifts 1309667 /Source="Nicolas_upshifts" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="upshifts" CDS 1309690..1311657 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9721285, 11722727, 12603740, 15317802, 23038252, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9721285, 11722727, 12603740, 15317802, 23038252, 27899502; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_389278.2" /db_xref="EnsemblGenomes-Gn:BSU13950" /db_xref="EnsemblGenomes-Tr:CAB13268" /db_xref="GOA:P54576" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG11533" /db_xref="UniProtKB/Swiss-Prot:P54576" /translation="MFKKLHMKIAVFVSIMLIITVVLLMLSSYLTLKPMITEDGKNTT QNVTQSLEQNIELQLKSYAISLSRLANGELTHTFVTKPSKEASRLFHDDIKQIKDNDD YVAMAYIGTAKKEMFTYPKADFAEDYDPTSRPWYKLAAETPDQVVWTEPYKDVVTGDM IVTASKAILDRQKVIGVASYDLKLSAIQSMVNKQKVPYKGFAFLADASGNLLAHPSNQ GKNISKDQTLQTIASEKKGIQDVNGKMVVYQTIGETGWKVGTQFDTDQLMWISDKMNR ANLWISLIALIITIILSYFLAKTITGPIQQLIVKTKAVSAGDLTVRAESKSKDEVGIL TRDFNLMVENMKEMVEQVRLSSGKVSDTSEQLTAVAAETNETSGQIAKAIEEVAAGAS EQASEVETINEKSESLSTKIRQIAEEAGGIKERSKSSEDASYKGLDALGQLLMKSNEA NMETKKVETMLLDLENQTKNIEEVVTAISNISDQTNLLALNASIEAARAGESGRGFAV VADEVRKLAEQSALSTKHISETVKLIQLETKEASHAMVEASRMNDEQNSAIHETGEVL NTITAEMQSLVQGIDHIYAEIQRMSEEQLAISEAIQSISAISQESAAAAEEVNASTDE QLVTLDKVKHSTETLKHASQELMNTIAKFTL*" /label="mcpC CDS" gene 1309690..1311657 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /label="mcpC gene" misc_feature complement(1310130..1310145) /Source="Nicolas_upshift_promotors" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1310142) /Source="Nicolas_upshifts" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1311628 /Source="Nicolas_upshifts" /id="D776" /incds=0 /nref=134 /ntot=209 /MaxReadThrough="3.05506" /MaxDrop="5.75836" /score="24.6367658" /energy="-12.1" /TU="U1141" /idTUdmin="U1141" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1311701..1311703 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1311719..1311738 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1311729 /Source="Nicolas_upshifts" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1311771) /Source="Nicolas_upshifts" /id="D777" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="2.29647" /MaxDrop="4.49503" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=946 /isTUend="FALSE" /label="downshifts" CDS 1311795..1312661 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /EC_number="1.1.1.60" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20941576, 24390483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20941576, 24390483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacid dehydrogenase (acts on 3-hydroxypropionate with NADP)" /protein_id="NP_389279.1" /db_xref="EnsemblGenomes-Gn:BSU13960" /db_xref="EnsemblGenomes-Tr:CAB13269" /db_xref="GOA:O34948" /db_xref="InterPro:IPR002204" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13328" /db_xref="UniProtKB/Swiss-Prot:O34948" /translation="MKKTIGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQK GAIWKDTVKDLSKEADVIITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSL AKKIAEAAKEKALFALDAPVSGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQ YQGPAGSGQHTKMCNQIAIAAGMIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWSLS NLAPRMLQGNFEPGFYVKHFIKDMGIALEEAELMGEEMPGLSLAKSLYDKLAAQGEEN SGTQSIYKLWVK*" /label="ohaC CDS" gene 1311795..1312661 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /label="ohaC gene" downshifts 1312641 /Source="Nicolas_upshifts" /id="D778" /incds=0 /nref=239 /ntot=266 /MaxReadThrough="2.14032" /MaxDrop="8.18847" /score="41.1703019" /energy="-14.5" /TU="NA" /idTUdmin="U1143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1312700..1313473) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389280.2" /db_xref="EnsemblGenomes-Gn:BSU13970" /db_xref="EnsemblGenomes-Tr:CAB13270" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR014258" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13329" /db_xref="UniProtKB/Swiss-Prot:O31398" /translation="MKKAFILSAAAAVGLFTFGGVQQASAKELSCQPVVTVKTGNTVQ NMSLNDAVKKLHINTNIKTLNAANEKEMKQLLQKHAKQSNVKVQDVQKTETAKPAQKT TEKAAADQNTASKAPATAEKTNTTTSAPSSVSAYEKKVVELTNAERQKQGLKPLQIDE TLSKSARAKSQDMKDKNYFDHQSPTYGSPFDMMKSFGISYKTAGENIAKGQKTPEEVV KAWMNSEGHRKNILNPNFTHIGVGYVESGSIWTQQFIGK*" /label="ykwD CDS" gene complement(1312700..1313473) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /label="ykwD gene" downshifts complement(1312717) /Source="Nicolas_upshifts" /id="D779" /incds=0 /nref=31 /ntot=168 /MaxReadThrough="1.32532" /MaxDrop="5.28625" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1313505..1313524) /Source="Nicolas_upshift_promotors" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1313515) /Source="Nicolas_upshifts" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1313748..1313767 /Source="Nicolas_upshift_promotors" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1313761 /Source="Nicolas_upshifts" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1313763..1313866 /Source="Nicolas_S_feature" /locus_tag="new_1467701_1467804" /HighExp="T4.0H, T3.30H, T3.0H, Etha, T5.0H, T2.30H, LoTm, B60, T2.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S507" CDS 1313810..1315924 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12896990, 23199363" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12896990, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding enzyme for formation of rod-shaped peptidoglycan cell wall" /protein_id="NP_389281.2" /db_xref="EnsemblGenomes-Gn:BSU13980" /db_xref="EnsemblGenomes-Tr:CAB13271" /db_xref="GOA:Q796K8" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13286" /db_xref="UniProtKB/Swiss-Prot:Q796K8" /translation="MTEIGREPKKKSKGNRAIRMNLFFLAVFVLFTALIFKLGVVQIV EGEQHEEDAEKSNAKTAYYPAPRGKMYDRNQKVAVDNQSVPEIVYVSTSSTKTEDKIK TAKRLASFIHIDTEFLKERDLRDYWIAAHPKKAAALLKESESNLKGDQAYKLQIERVP DQELKAIQQDDEEMETAAIYTRFSSGNAYEPQIVKAMNPNKSNSNGKNGALLDEKKNS SQRPKNDLTYDEISIVSEHLEELPGIDIVNDWTRKYPYDKTLYSVFGGVTTPDQGLLS DRKDFYLTRGYANNDRVGKSYLEYQYEEYLNSHKEKVEYVEDNKGNVVSQKTIDKGSR GYDLQLSFDMELQAKVEKIIEEEVRNSRARGNYMLDRAFAVMMDPNNGDILSMAGKKI DLKTNKIEDYAIGAFTTQYEMGSAVKGATVLAGYQDGIPHYKYYIDAPMLLGTNLIKK SYTNMGTINELTALQKSSNVYMFNVAMHIAGVTYKPHGSLPADQNDLLKMRNYYSQFG LGVKTGIDLPQESAGMQTTPKTVGGLILDLAIGQYDTYTPLQMAQYISVIANGGYRVQ PRIVTSIHKPGKKDQLGKAIEHRKPKVLNKINNSESDLKQVQTGMKLVTSSGTAKNTF TEDVSGKTGTAETFYYGTNRNWWGKKTYNLTFVGYYPSKKPKVAFSVVVPSVDDDDKI NKIIAKRAIHAYAELEKKHSKK*" /label="pbpH CDS" gene 1313810..1315924 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /label="pbpH gene" promotor_-10 complement(1315103..1315121) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1315115) /Source="Nicolas_upshifts" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1315137..1315142) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1315905 /Source="Nicolas_upshifts" /id="D780" /incds=0 /nref=139 /ntot=246 /MaxReadThrough="3.36066" /MaxDrop="5.01597" /score="-1.2500858" /energy="-12" /TU="U1145" /idTUdmin="U1145" /TUdmin="-1862" /isTUend="FALSE" /label="downshifts" promotor_-35 1315997..1316005 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1316017..1316035 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1316029 /Source="Nicolas_upshifts" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="upshifts" CDS 1316088..1317908 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific ATP-dependent protein histidine kinase" /protein_id="NP_389282.1" /db_xref="EnsemblGenomes-Gn:BSU13990" /db_xref="EnsemblGenomes-Tr:CAB13272" /db_xref="GOA:P16497" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013655" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:2VLG" /db_xref="SubtiList:BG10204" /db_xref="UniProtKB/Swiss-Prot:P16497" /translation="MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGE MIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAER TEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISV KGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQ TWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNS IDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQ KTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEK LSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELL MLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQ VFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE KGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK*" /label="kinA CDS" gene 1316088..1317908 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /label="kinA gene" CDS complement(1317919..1319100) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /EC_number="2.6.1.83" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 14523133, 14627808, 19948795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 14523133, 14627808, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-L,L-diaminopimelate aminotransferase" /protein_id="NP_389283.2" /db_xref="EnsemblGenomes-Gn:BSU14000" /db_xref="EnsemblGenomes-Tr:CAB13273" /db_xref="GOA:P16524" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10205" /db_xref="UniProtKB/Swiss-Prot:P16524" /translation="MEHLLNPKAREIEISGIRKFSNLVAQHEDVISLTIGQPDFFTPH HVKAAAKKAIDENVTSYTPNAGYLELRQAVQLYMKKKADFNYDAESEIIITTGASQAI DAAFRTILSPGDEVIMPGPIYPGYEPIINLCGAKPVIVDTTSHGFKLTARLIEDALTP NTKCVVLPYPSNPTGVTLSEEELKSIAALLKGRNVFVLSDEIYSELTYDRPHYSIATY LRDQTIVINGLSKSHSMTGWRIGFLFAPKDIAKHILKVHQYNVSCASSISQKAALEAV TNGFDDALIMREQYKKRLDYVYDRLVSMGLDVVKPSGAFYIFPSIKSFGMTSFDFSMA LLEDAGVALVPGSSFSTYGEGYVRLSFACSMDTLREGLDRLELFVLKKREAMQTINNG V*" /label="dapX CDS" gene complement(1317919..1319100) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /label="dapX gene" downshifts complement(1317953) /Source="Nicolas_upshifts" /id="D781" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="1.89632" /MaxDrop="6.70715" /score="-6.17975559" /energy="-4.7" /TU="NA" /idTUdmin="U1148" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1319128..1319147) /Source="Nicolas_upshift_promotors" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1319144) /Source="Nicolas_upshifts" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1319176..1319194) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1319188) /Source="Nicolas_upshifts" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1319190..1319258) /Source="Nicolas_S_feature" /locus_tag="new_1473128_1473196_c" /HighExp="M9-stat, Lbtran, Lbstat, T3.30H, T3.0H, T2.30H, M0t90, T4.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S508" promotor_-35 complement(1319209..1319214) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1319252..1319271) /Source="Nicolas_upshift_promotors" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1319258) /Source="Nicolas_upshifts" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1319302..1319463) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097722.1" /db_xref="EnsemblGenomes-Gn:BSU14009" /db_xref="EnsemblGenomes-Tr:CAX52613" /db_xref="UniProtKB/Swiss-Prot:C0H406" /translation="MGTLVIFKENEMTVLEDISEETYLNMKKESADLQEEHPPYLIWH EDLHFDYGY*" /label="ykzT CDS" gene complement(1319302..1319463) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /label="ykzT gene" promotor_-10 complement(1319486..1319505) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1319499) /Source="Nicolas_upshifts" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1319519..1319526) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1319600..1319607 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1319619 /Source="Nicolas_upshifts" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1319620..1319638 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1319667..1320578 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11553614, 12864845, 14731274, 14993307, 26844549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11553614, 12864845, 14731274, 14993307, 26844549; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling protein and response regulator for CheAactivity in response to attractants (chemotaxis)" /protein_id="NP_389284.1" /db_xref="EnsemblGenomes-Gn:BSU14010" /db_xref="EnsemblGenomes-Tr:CAB13274" /db_xref="GOA:P37599" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024181" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10823" /db_xref="UniProtKB/Swiss-Prot:P37599" /translation="MSLQQYEILLDSGTNELEIVKFGVGENAFGINVMKVREIIQPVE VTSVPHSHQHVEGMIKLRGEILPVISLFSFFGVEPEGSKDEKYIVTEFNKRKIVFHVG SVSQIHRVSWEAIEKPTSLNQGMERHLTGIIKLEDLMIFLPDYEKIIYDIESDSGVDT YNMHTEGFDERRTDKKLIIVEDSPLLMRLLQDELKEAGYNNIASFENGKEAYEYIMNL AENETDLSKQIDMIITDIEMPKMDGHRLTKLLKENPKSSDVPVMIFSSLITDDLRHRG EVVGADEQISKPEISDLIKKVDTYVIE*" /label="cheV CDS" gene 1319667..1320578 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /label="cheV gene" downshifts complement(1319672) /Source="Nicolas_upshifts" /id="D782" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="1.14523" /MaxDrop="3.62759" /score="-8.29055697" /energy="-7.7" /TU="NA" /idTUdmin="U1154" /TUdmin=968 /isTUend="FALSE" /label="downshifts" promotor_-35 1320121..1320129 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1320143..1320160 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1320146 /Source="Nicolas_upshifts" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1320563 /Source="Nicolas_upshifts" /id="D783" /incds=0 /nref=188 /ntot=251 /MaxReadThrough="4.61331" /MaxDrop="6.23797" /score="15.4598573" /energy="-13.1" /TU="U1152" /idTUdmin="U1153" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1320622..1321086) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of transcription factor ComK function via modulation of mRNA stability" /protein_id="NP_389285.1" /db_xref="EnsemblGenomes-Gn:BSU14020" /db_xref="EnsemblGenomes-Tr:CAB13275" /db_xref="InterPro:IPR025552" /db_xref="SubtiList:BG11202" /db_xref="UniProtKB/Swiss-Prot:P42430" /translation="MDDHAYTKDLQPTVENLSKAVYTVNRHAKTAPNPKYLYLLKKRA LQKLVKEGKGKKIGLHFSKNPRFSQQQSDVLISIGDYYFHMPPTKEDFEHLPHLGTLN QSYRNPKAQMSLTKAKHLLQEYVGMKEKPLVPNRQQPAYHKPVFKKLGESYF*" /label="kre CDS" gene complement(1320622..1321086) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /label="kre gene" downshifts complement(1320640) /Source="Nicolas_upshifts" /id="D784" /incds=0 /nref=212 /ntot=260 /MaxReadThrough="2.67186" /MaxDrop="6.66359" /score="16.1985615" /energy="-13.1" /TU="NA" /idTUdmin="U1154" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1321116..1321135) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1321126) /Source="Nicolas_upshifts" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1321150..1321157) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1321212..1322504) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389286.2" /db_xref="EnsemblGenomes-Gn:BSU14030" /db_xref="EnsemblGenomes-Tr:CAB13276" /db_xref="GOA:O31695" /db_xref="InterPro:IPR004751" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13287" /db_xref="UniProtKB/Swiss-Prot:O31695" /translation="MDIFKNRNFVRLFFAALASQMGTTVGNMAFAFFLLDRFSSQPSY TTLAELMYSLPTIFVFLIVGVVADRFDRKKVAENCDWIRAGLTVVLFFTLFTGNIPLV FCILFIRSAVTKFFFPAENSLVQAILPKEHYAKAAGLNQMLFSIFMVFGVGIGAFMYN TIGIEGAIILDFVSFIISGLLIRSCRIPKEARQPNGAFSWRKTSVKDSINDFREGILY ILKNKLLASLIFGFFIFGFVNGGFAVLPMFTMKYGLAPDRYEWHTSVFTIALGFGLLA GSVIGTLISKKVKPHFLMSIPIFIAGLLIFVLGYTNILWVYYAAAFALGMCIGPINIA IGGWMPKIVHPKLMGRVSGMQDPFMMFAQSLTLGLVALLFPKFVSNIDYLYYGMGVII LLVFIFYFIALPKYSAQAVEVNVQEAFQEQPKKKARSV*" /label="ykuC CDS" gene complement(1321212..1322504) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /label="ykuC gene" downshifts complement(1321234) /Source="Nicolas_upshifts" /id="D785" /incds=0 /nref=37 /ntot=206 /MaxReadThrough="4.24449" /MaxDrop="4.31411" /score="3.5676583" /energy="-14.2" /TU="U1155" /idTUdmin="U1156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1322528..1322547) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-10" upshifts complement(1322532) /Source="Nicolas_upshifts" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="upshifts" promotor_-35 complement(1322563..1322567) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-35" CDS complement(1322580..1323074) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11011148, 16287140, 23832002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16287140, 23832002; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="murein L,D-transpeptidase" /protein_id="NP_389287.1" /db_xref="EnsemblGenomes-Gn:BSU14040" /db_xref="EnsemblGenomes-Tr:CAB13277" /db_xref="GOA:O34816" /db_xref="InterPro:IPR005490" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:1Y7M" /db_xref="PDB:2MTZ" /db_xref="PDB:3ZQD" /db_xref="PDB:4A1I" /db_xref="PDB:4A1J" /db_xref="PDB:4A1K" /db_xref="PDB:4A52" /db_xref="SubtiList:BG13288" /db_xref="UniProtKB/Swiss-Prot:O34816" /translation="MLTYQVKQGDTLNSIAADFRISTAALLQANPSLQAGLTAGQSIV IPGLPDPYTIPYHIAVSIGAKTLTLSLNNRVMKTYPIAVGKILTQTPTGEFYIINRQR NPGGPFGAYWLSLSKQHYGIHGTNNPASIGKAVSKGCIRMHNKDVIELASIVPNGTRV TINR*" /label="ltdD CDS" gene complement(1322580..1323074) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /label="ltdD gene" promotor_-10 complement(1323090..1323109) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1323106) /Source="Nicolas_upshifts" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1323123..1323132) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1323131..1323991) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22767609, 24140208" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22767609, 24140208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported metallophosphoesterase (Mn2+ and Zn2+)" /protein_id="NP_389288.2" /db_xref="EnsemblGenomes-Gn:BSU14050" /db_xref="EnsemblGenomes-Tr:CAB13278" /db_xref="GOA:O34870" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR019546" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13289" /db_xref="UniProtKB/Swiss-Prot:O34870" /translation="MKKMSRRQFLKGMFGALAAGALTAGGGYGYARYLEPHMIETTEH TIKSSLIPHGFDGFKIVQFSDAHLSDYFTLEDLKTVILTINESKPDLIVFTGDIIDNP DTYQHHQAVIPLLRKLNAPFGKLCIYGNHDHGGYGTAVYKSLMTAGGFTVYRNGYQTL SLADGSKIEIASLDDLMLGNPDYEGTLSRLSDRLFSILLVHEPDAALKTTDYPVNLQL SGHTHGGQIQLPFYGPIITPPYGKVYTEGMYQTGSTHIYVNRGLGMTRLPLRFLAKPE ITVFTLKSTN*" /label="ppeE CDS" gene complement(1323131..1323991) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /label="ppeE gene" misc_feature complement(1324012..1324031) /Source="Nicolas_upshift_promotors" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1324025) /Source="Nicolas_upshifts" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="upshifts" promotor_-35 1324062..1324069 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-35" promotor_-10 1324085..1324104 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-10" upshifts 1324098 /Source="Nicolas_upshifts" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="upshifts" CDS 1324134..1324898 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /EC_number="1.3.1.34" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2,4-dienoyl-CoA reductase" /protein_id="NP_389289.1" /db_xref="EnsemblGenomes-Gn:BSU14060" /db_xref="EnsemblGenomes-Tr:CAB13279" /db_xref="GOA:O34717" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13290" /db_xref="UniProtKB/Swiss-Prot:O34717" /translation="MEKKAVIITGGSSGMGKAMAKKQAELGWHVMVTGRNHEALEETK KEIQTFEGQVACFQMDVRSDSAASDMIKEAVKAFGRLDALINNAAGNFICPAEKLTPN GWKAVIEIVLNGTFFCSQAAARHWIDQKQQGVILNMAATYAWGAGAGVVHSAAAKAGV LSLTRTLAVEWGSKYGIRTNAIAPGPIERTGGAEKLFESEKAMARTMNSVPLGRLGTP EEIAALAAFLLSDEASYINGDCITMDGGQWLNPYPF*" /label="fadH CDS" gene 1324134..1324898 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /label="fadH gene" S_feature 1324899..1325047 /Source="Nicolas_S_feature" /locus_tag="new_1478837_1478985" /HighExp="T0.30H, T1.0H, B60, Sw, BC, LoTm, M9-stat, S8, S7, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S509" misc_feature 1325028..1325046 /Source="Nicolas_upshift_promotors" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1325049..1325198 /Source="Nicolas_S_feature" /locus_tag="new_1478987_1479136" /HighExp="T0.30H, M40t90, T1.0H, B60, BC, Sw, LPh, LoTm, M9-stat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0, 0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S510" upshifts 1325049 /Source="Nicolas_upshifts" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1325096) /Source="Nicolas_upshifts" /id="D786" /incds=0 /nref=3 /ntot=49 /MaxReadThrough="1.82681" /MaxDrop="3.39884" /score="-0.170855674" /energy="-4.8" /TU="NA" /idTUdmin="U1157" /TUdmin="-2542" /isTUend="FALSE" /label="downshifts" CDS 1325199..1326929 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall-binding protein" /protein_id="YP_003097723.1" /db_xref="EnsemblGenomes-Gn:BSU14071" /db_xref="EnsemblGenomes-Tr:CAX52614" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="UniProtKB/Swiss-Prot:O34320" /translation="MDEMVLLTQEWLNETYKGKSGYNSIEENGKTGWKTMYALTRALQ LELGITQTSDSFGPTTLRKLKELGPISTSTNSKKNIVKIIQGALYCKGYGPGGLTGTF GQGTKEAIAEMQLHMGLSKTDGVVTPKVFKALLNMDSYILLNGASEKVRSIQQWLNNK YYNRENFYFMPCDGLYSRDTQKSLVYAIQYEEGLSDSIANGNFGPTTQRLIPVLRIGE TDEKNSFIHLFQAALIFNGYNVPFDGVYSESVRSKVKAFQSFAKLQQSGTADFQTWAS LLVSTGDPNRKGVACDSITQITSDRAESLKRAGYKIVGRYLTNAPGSTLNKKIQPGEL ETILKSGLNVFPIYQTYGGATNYFNKEQGKKDAFAAYKAAKEYGFKNNTVIYFAVDYD AYGNDLNNNIIPHFEGINEIMNGFLGSTYKIGIYAPRNVCTIVSKKGLAFASFVSGMS TGFSGNLGYPLPYNWAFDQISTITVGNGSGMIEIDNDICSGLDNGVNTINIVPSENKK FFDQIDVLYETAEKYAQMQSDLNNGVKKTQLANELVAQYLRKDDYKGWKWVPTAGQID PIYREWAVKR*" /label="ykuG CDS" gene 1325199..1326929 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /label="ykuG gene" CDS 1326995..1327513 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097724.1" /db_xref="EnsemblGenomes-Gn:BSU14072" /db_xref="EnsemblGenomes-Tr:CAX52615" /db_xref="UniProtKB/Swiss-Prot:C0H408" /translation="MATYNAIIYSGGYSQTLRDFAGWTGDLLTTIQDMKLHAQEFNSP YDAAMKIIGNMYQFSLDDLFSDVDAINLANKTSVGANAQPLNIAIRDYYSNNDCMNRF TQFVNNRFDGSLDKIFSEAEYYLNTNLDPVVVPIRLAFKRAFDVEDYSEEIGKITAQA FRDVIEKKMISE*" /label="ykzU CDS" gene 1326995..1327513 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /label="ykzU gene" downshifts 1327511 /Source="Nicolas_upshifts" /id="D787" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.57306" /MaxDrop="3.8585" /score="8.20824413" /energy="-13" /TU="U1158,U1159" /idTUdmin="U1158" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 1327556..1327561 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1327574..1327593 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1327577 /Source="Nicolas_upshifts" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="upshifts" CDS 1327609..1328157 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389291.1" /db_xref="EnsemblGenomes-Gn:BSU14080" /db_xref="EnsemblGenomes-Tr:CAB13281" /db_xref="GOA:O31696" /db_xref="SubtiList:BG13292" /db_xref="UniProtKB/Swiss-Prot:O31696" /translation="MKKLLKKLVVLFLSSLVIIFNVWYFIICAFSPEYYQNTNLTSNE IIRFEKLYHIDFPDETKFIKAREYLAGPGGDTSAVLYVSLPTKRVEKVLSDYTYMKIN YTDNVGSMYGVDVSKSVAGLTTLTFGTYDKKGTFYNMKHDDDWMYKGTDWNLYFWTAA SYNAVIFVFVLVIVKQMNKILN*" /label="ykuH CDS" gene 1327609..1328157 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /label="ykuH gene" S_feature 1328158..1328309 /Source="Nicolas_S_feature" /locus_tag="new_1482096_1482247" /HighExp="HiOs, LPhT, Salt, T0.0H, HiTm, T-0.40H, Fru, T-1.10H, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S511" CDS 1328310..1329533 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19244251, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative cyclic-di-GMP receptor (no phosphodiesterase activity)" /protein_id="NP_389292.1" /db_xref="EnsemblGenomes-Gn:BSU14090" /db_xref="EnsemblGenomes-Tr:CAB13282" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR018842" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035919" /db_xref="PDB:2BAS" /db_xref="PDB:2W27" /db_xref="SubtiList:BG13293" /db_xref="UniProtKB/Swiss-Prot:O35014" /translation="MLDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEI QSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESF LELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSN LDRIALLSPDLLKIDLQALKVSQPSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQ YAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFY KRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWI YQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLF IDLPYSYLYEQDGLI*" /label="ykuI CDS" gene 1328310..1329533 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /label="ykuI gene" promotor_-10 complement(1329496..1329514) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1329506) /Source="Nicolas_upshifts" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1329512 /Source="Nicolas_upshifts" /id="D788" /incds=0 /nref=132 /ntot=229 /MaxReadThrough="3.48305" /MaxDrop="4.61382" /score="32.6727777" /energy="-7.5" /TU="U1159" /idTUdmin="U1160" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(1329529..1329534) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1329582..1329589 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1329601..1329702 /Source="Nicolas_S_feature" /locus_tag="new_1483539_1483640" /HighExp="B36, B60, nit, Pyr, BI, HiOs, T-0.40H, S5, GM 15, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S512" upshifts 1329601 /Source="Nicolas_upshifts" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1329604..1329623 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" misc_RNA 1329619..1329702 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /product="regulatory RNA controlling iron-dependent metabolism" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629, 24576839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629, 24576839; Product type n: RNA" /function="12: Regulatory functions" /label="fsrA RNA" gene 1329619..1329702 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /label="fsrA gene" downshifts 1329659 /Source="Nicolas_upshifts" /id="D789" /incds=0 /nref=61 /ntot=192 /MaxReadThrough="6.41968" /MaxDrop="7.54463" /score="16.5898261" /energy="-8.8" /TU="U1159,U1162" /idTUdmin="U1159" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 1329713..1329718 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1329733..1330017 /Source="Nicolas_S_feature" /locus_tag="new_1483671_1483955" /HighExp="S4, H2O2, S5, Paraq, B60, nit, GM 10, B36, GM 25, GM 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147452" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S513" upshifts 1329733 /Source="Nicolas_upshifts" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1329735..1329753 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-10" promotor_-35 1329994..1330000 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" promotor_-10 1330014..1330025 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" S_feature 1330019..1330106 /Source="Nicolas_S_feature" /locus_tag="new_1483957_1484044" /HighExp="S5, S4, H2O2, B60, Paraq, nit, B36, GM 10, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigEF, SigA" /TUshortPSig="0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S514" upshifts 1330019 /Source="Nicolas_upshifts" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" misc_feature 1330095..1330114 /Source="Nicolas_upshift_promotors" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1330108 /Source="Nicolas_upshifts" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1330179..1330418 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16387657, 18436958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-specific modification enzyme subunit" /protein_id="NP_389293.1" /db_xref="EnsemblGenomes-Gn:BSU14100" /db_xref="EnsemblGenomes-Tr:CAB13283" /db_xref="InterPro:IPR014904" /db_xref="PDB:2FFG" /db_xref="SubtiList:BG13294" /db_xref="UniProtKB/Swiss-Prot:O34588" /translation="MSQLMGIITRLQSLQETAEAANEPMQRYFEVNGEKICSVKYFEK NQTFELTVFQKGEKPNTYPFDNIDMVSIEIFELLQ*" /label="ykuJ CDS" gene 1330179..1330418 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /label="ykuJ gene" S_feature 1330419..1330527 /Source="Nicolas_S_feature" /locus_tag="new_1484357_1484465" /HighExp="H2O2, LoTm, G135, Paraq, G180, LBGexp, G150, Oxctl, dia0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S515" CDS 1330528..1331046 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16165328, 24464998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding enzyme component" /protein_id="NP_389294.1" /db_xref="EnsemblGenomes-Gn:BSU14110" /db_xref="EnsemblGenomes-Tr:CAB13284" /db_xref="InterPro:IPR007405" /db_xref="SubtiList:BG13295" /db_xref="UniProtKB/Swiss-Prot:O34776" /translation="MADSFLFYNLSEAQMTFQDVMERLKAFVQKDPRSSYVLSIGTDS QVYRDYTKFITALHLHRTGKGAWGCLKNHTVDRPIHSLREKISLETAYSQETAAHILD GHLMDITDLLLPFTGEGADLTFEVHLDIGKKGLTKDLIQEMTGRITSMGIEAKIKPDS YTAFSYANRFTK*" /label="ykuK CDS" gene 1330528..1331046 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /label="ykuK gene" promotor_-35 1331083..1331090 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1331104..1331123 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1331118 /Source="Nicolas_upshifts" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1331180..1331377 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18840696, 24534728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18840696, 24534728; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of AbrB repressor" /protein_id="NP_389295.1" /db_xref="EnsemblGenomes-Gn:BSU14120" /db_xref="EnsemblGenomes-Tr:CAB13285" /db_xref="GOA:O31697" /db_xref="InterPro:IPR025446" /db_xref="PDB:2LZF" /db_xref="SubtiList:BG13334" /db_xref="UniProtKB/Swiss-Prot:O31697" /translation="MRMSLIGERFTEEEQKLLLNILINHEYAIELLSSEINDIETGTK NVDGTTYKKLVTLYDRFRFEN*" /label="abbA CDS" gene 1331180..1331377 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /label="abbA gene" downshifts 1331373 /Source="Nicolas_upshifts" /id="D790" /incds=0 /nref=114 /ntot=265 /MaxReadThrough="5.72556" /MaxDrop="4.65809" /score="2.45376472" /energy="-6.8" /TU="U1165,U1166" /idTUdmin="U1162" /TUdmin=12 /isTUend="TRUE" /label="downshifts" S_feature 1331418..1331514 /Source="Nicolas_S_feature" /locus_tag="new_1485356_1485452" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, M0t90, T1.0H, T5.0H, T2.30H, T1.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.23094000000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S516" CDS 1331515..1331958 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11985717; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA-binding protein" /protein_id="NP_389296.1" /db_xref="EnsemblGenomes-Gn:BSU14130" /db_xref="EnsemblGenomes-Tr:CAB13286" /db_xref="PDB:1YAV" /db_xref="SubtiList:BG13296" /db_xref="UniProtKB/Swiss-Prot:O31698" /translation="MISLQSDQLLEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTG YTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDP IMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRSLNK*" /label="ykuL CDS" gene 1331515..1331958 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /label="ykuL gene" S_feature 1331959..1332066 /Source="Nicolas_S_feature" /locus_tag="new_1485897_1486004" /HighExp="M0t90, M40t90, M9-stat, T1.0H, T3.30H, T3.0H, T4.0H, S2, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S517" promotor_-35 1332034..1332039 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1332054..1332073 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1332068 /Source="Nicolas_upshifts" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1332107..1332988 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14636591, 16352834, 16395550, 23139400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636591, 16352834, 16395550, 23139400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of citB and citZ" /protein_id="NP_389297.1" /db_xref="EnsemblGenomes-Gn:BSU14140" /db_xref="EnsemblGenomes-Tr:CAB13287" /db_xref="GOA:O34827" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13297" /db_xref="UniProtKB/Swiss-Prot:O34827" /translation="MQLQELHMLVVLAEELNMRKAAERLFVSQPALSQRLQTIEKAWG TKIFLRSQKGLTVTPAGEKIIQFANDVTLEQERIRENIDELEGEIHGTLKLAVASIIG QHWLPKVLKTYVEKYPNAKISLITGWSSEMLKSLYEDQVHIGIIRGNPEWKGRKDYLM TDHLYLVDTEISCIEDIAHTERPFIQFKSDSTYFQEIQHWWHQKFKTSPKQTILVDQI ETCKQMALHGIGYAILPSVTLQNEDKVNKMPLLDMKGHPIGRDTWLLGYEPAFELKQV QAFVQVIKDMLDQENPF*" /label="ccpC CDS" gene 1332107..1332988 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /label="ccpC gene" downshifts 1332967 /Source="Nicolas_upshifts" /id="D791" /incds=0 /nref=168 /ntot=242 /MaxReadThrough="1.76921" /MaxDrop="5.2505" /score="37.6563581" /energy="-8.3" /TU="NA" /idTUdmin="U1165" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1333023..1333030 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1333045..1333064 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1333050 /Source="Nicolas_upshifts" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1333100..1333576 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin (acts in lipid desaturation)" /protein_id="NP_389298.1" /db_xref="EnsemblGenomes-Gn:BSU14150" /db_xref="EnsemblGenomes-Tr:CAB13288" /db_xref="GOA:O34737" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13298" /db_xref="UniProtKB/Swiss-Prot:O34737" /translation="MAKALITYASMSGNTEDIAFIIKDTLQEYELDIDCVEINDMDAS CLTSYDYVLIGTYTWGDGDLPYEAEDFFEEVKQIQLNGLKTACFGSGDYSYPKFCEAV NLFNVMLQEAGAAVYQETLKIELAPETDEDVESCRAFARGFLAWADYMNKEKIHVS*" /label="fldN CDS" gene 1333100..1333576 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /label="fldN gene" CDS 1333566..1334459 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12354229, 24214949" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389299.1" /db_xref="EnsemblGenomes-Gn:BSU14160" /db_xref="EnsemblGenomes-Tr:CAB13289" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG13299" /db_xref="UniProtKB/Swiss-Prot:O34879" /translation="MFHKGATAVTASAFSGYFVAVQREGIFHYSLEQGWRKLFRLKSK IHCISYIGPYLFGVGEKGTVIRSADEGKTWTMSSFPTNATVWAITGRNNGFVCAHGKH CIYVSDDFGVSWRVAKPFAEFHNPPVIRSLCLHGGNLFIGTQIHEYFGGIWAYDIKRD TVQVVKKEKNRMTASMLVFNENWLVAAMGSVKGKHGAVTVRNLLNGEEFTIQSSMIRN EESFLDLSEDDGIIYVTTTQDENGFSRIYQVDLEARSLKWFDTIKGHGWRVANQKENF FCAGLYECKFVQPYEVSAMIH*" /label="ykuO CDS" gene 1333566..1334459 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /label="ykuO gene" CDS 1334475..1334930 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin" /protein_id="NP_389300.2" /db_xref="EnsemblGenomes-Gn:BSU14170" /db_xref="EnsemblGenomes-Tr:CAB13290" /db_xref="GOA:O34589" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001226" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13300" /db_xref="UniProtKB/Swiss-Prot:O34589" /translation="MAKILLVYATMSGNTEAMADLIEKGLQEALAEVDRFEAMDIDDA QLFTDYDHVIMGTYTWGDGDLPDEFLDLVEDMEEIDFSGKTCAVFGSGDTAYEFFCGA VDTLEAKIKERGGDIVLPSVKIENNPEGEEEEELINFGRQFAKKSGCAV*" /label="fldP CDS" gene 1334475..1334930 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /label="fldP gene" promotor_-10 complement(1334746..1334765) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1334759) /Source="Nicolas_upshifts" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1334779..1334787) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1334924 /Source="Nicolas_upshifts" /id="D792" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="6.48855" /MaxDrop="3.75748" /score="20.7202933" /energy="-9" /TU="U1168" /idTUdmin="U1165" /TUdmin=1957 /isTUend="FALSE" /label="downshifts" promotor_-35 1334969..1334976 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1334990..1335009 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1334991 /Source="Nicolas_upshifts" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1335035..1335745 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /EC_number="2.3.1.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5411754, 10368155, 11910040, 12682299, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5411754, 10368155, 11910040, 12682299, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetrahydrodipicolinate N-acetyltransferase" /protein_id="NP_389301.2" /db_xref="EnsemblGenomes-Gn:BSU14180" /db_xref="EnsemblGenomes-Tr:CAB13291" /db_xref="GOA:O34981" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR013710" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR019873" /db_xref="SubtiList:BG13301" /db_xref="UniProtKB/Swiss-Prot:O34981" /translation="MKMMDANEIISFIQNSTKSTPVKVYVKGELEGINFGESAKAFIN GNTGVVFGEWSEIQTAIEENQSKIEDYVVENDRRNSAIPMLDLKNIKARIEPGAIIRD QVEIGDNAVIMMGASINIGSVIGEGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVIEP PSAKPVVIEDDVVIGANAVVLEGVTVGKGAVVAAGAIVVNDVEPYTVVAGTPAKKIKD IDEKTKGKTEIKQELRQL*" /label="dapH CDS" gene 1335035..1335745 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /label="dapH gene" downshifts complement(1335044) /Source="Nicolas_upshifts" /id="D793" /incds=0 /nref=60 /ntot=165 /MaxReadThrough="1.03272" /MaxDrop="4.75802" /score="28.9046709" /energy="-15" /TU="NA" /idTUdmin="U1171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1335154..1335158) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1335154) /Source="Nicolas_upshifts" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1335815..1336939 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /EC_number="3.5.1.47" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14627808, 17093042, 24261876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14627808, 17093042, 24261876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-diaminopimelate deacetylase" /protein_id="NP_389302.1" /db_xref="EnsemblGenomes-Gn:BSU14190" /db_xref="EnsemblGenomes-Tr:CAB13292" /db_xref="GOA:O34916" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR023905" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13302" /db_xref="UniProtKB/Swiss-Prot:O34916" /translation="MKIEELIAIRRDLHRIPELGFQEFKTQQYLLNVLEQYPQDRIEI EKWRTGLFVKVNGTAPEKMLAYRADIDALSIEEQTGLPFASEHHGNMHACGHDLHMTI ALGIIDHFVHHPVKHDLLFLFQPAEEGPGGAEPMLESDVLKKWQPDFITALHIAPELP VGTIATKSGLLFANTSELVIDLEGKGGHAAYPHLAEDMVVAASTLVTQLQTIISRNTD PLDSAVITVGTITGGSAQNIIAETAHLEGTIRTLSEESMKQVKERIEDVVKGIEIGFR CKGKVTYPSVYHQVYNTSGLTEEFMSFVAEHQLATVIEAKEAMTGEDFGYMLKKYPGF MFWLGADSEHGLHHAKLNPDENAIETAVHVMTGYFSVYAN*" /label="dapI CDS" gene 1335815..1336939 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /label="dapI gene" promotor_-35 1336951..1336957 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1336971..1336982 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1336973 /Source="Nicolas_upshifts" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1336977..1336991) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1337001..1337005) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1337001..1337246 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389303.1" /db_xref="EnsemblGenomes-Gn:BSU14200" /db_xref="EnsemblGenomes-Tr:CAB13293" /db_xref="InterPro:IPR005370" /db_xref="SubtiList:BG13303" /db_xref="UniProtKB/Swiss-Prot:O34783" /translation="MAKKIGIEQSLSDVEAALKEKGYDVVMMKSPADAQGCDCCVVTG LDNNVQGIADTVTQAPVITASGMTAEEICSEVESRIQ*" /label="ykuS CDS" gene 1337001..1337246 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /label="ykuS gene" upshifts complement(1337002) /Source="Nicolas_upshifts" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1337234 /Source="Nicolas_upshifts" /id="D794" /incds=0 /nref=238 /ntot=269 /MaxReadThrough="3.49553" /MaxDrop="5.88829" /score="3.56597112" /energy="-9.9" /TU="U1172" /idTUdmin="U1168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1337279..1338229 /Source="Nicolas_S_feature" /locus_tag="new_1491217_1492167" /HighExp="S4, S5, S6, S3, S7, S8, LoTm, BT, B36, G135" /AntisenseName="ykuT" /AntisenseCor="-0.479447808227356" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S518" CDS complement(1337283..1338086) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /function="16.6: Maintain" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12626684, 17665170, 18310427, 19252899, 21150093" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12626684, 17665170, 18310427, 19252899, 21150093; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small-conductance mechanosensitive channel" /protein_id="NP_389304.2" /db_xref="EnsemblGenomes-Gn:BSU14210" /db_xref="EnsemblGenomes-Tr:CAB13294" /db_xref="GOA:O34897" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13304" /db_xref="UniProtKB/Swiss-Prot:O34897" /translation="MDFIKQYDWAGLITNAGVLLIKLAIMILLYFIVRSLGMKIIKHL FAKFEEQNSLSIGRAHTLRSLTLNIFAYTLIFIFFVMVLDLFHYDPSALLAGAGIVGL AVGFGAQGLVSDIVTGFFILLEKQLDVGDYITVSTFDGIVEQVGLRTTQIRSFDGTLH YIPNRNITNVSNHSRGTMQALVDIKVPAERNIDEMIHILQQVCDETAAALPQIKEGPN VIGIQELGTSEIVIRVIAKTENMEQWRVERVLRKEIKNAFDRAFPKETE*" /label="mscT CDS" gene complement(1337283..1338086) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /label="mscT gene" downshifts complement(1337295) /Source="Nicolas_upshifts" /id="D795" /incds=0 /nref=16 /ntot=131 /MaxReadThrough="1.65551" /MaxDrop="4.4361" /score="29.0050313" /energy="-9.9" /TU="NA" /idTUdmin="U1174" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1338137..1338156) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1338146) /Source="Nicolas_upshifts" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1338170..1338177) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1338202..1338209 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-35" promotor_-10 1338224..1338243 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-10" S_feature 1338231..1338322 /Source="Nicolas_S_feature" /locus_tag="new_1492169_1492260" /HighExp="LPhT, Salt, Etha, M9-stat, M0t90, T4.0H, T5.0H, S4, Heat, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S519" upshifts 1338231 /Source="Nicolas_upshifts" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="upshifts" CDS 1338323..1338865 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /EC_number="1.11.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:22938038, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22938038, 27683249; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biofilm-specific peroxidase; 2-cys peroxiredoxin" /protein_id="NP_389305.1" /db_xref="EnsemblGenomes-Gn:BSU14220" /db_xref="EnsemblGenomes-Tr:CAB13295" /db_xref="GOA:O34564" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13305" /db_xref="UniProtKB/Swiss-Prot:O34564" /translation="MAERMVGKQAPRFEMEAVLASKEFGKVSLEENMKNDKWTVLFFY PMDFTFVCPTEITAMSDRYDEFEDLDAEVIGVSTDTIHTHLAWINTDRKENGLGQLKY PLAADTNHEVSREYGVLIEEEGVALRGLFIINPEGELQYQTVFHNNIGRDVDETLRVL QALQTGGLCPANWKPGQKTL*" /label="ahpA CDS" gene 1338323..1338865 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /label="ahpA gene" CDS 1338937..1339383 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /EC_number="1.8.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15937154, 16132829, 16418167" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 16132829, 16418167; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_389306.2" /db_xref="EnsemblGenomes-Gn:BSU14230" /db_xref="EnsemblGenomes-Tr:CAB13296" /db_xref="GOA:O31699" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:2B5X" /db_xref="PDB:2B5Y" /db_xref="SubtiList:BG13306" /db_xref="UniProtKB/Swiss-Prot:O31699" /translation="MKLRQPMPELTGEKAWLNGEVTREQLIGEKPTLIHFWSISCHLC KEAMPQVNEFRDKYQDQLNVVAVHMPRSEDDLDPGKIKETAAEHDITQPIFVDSDHAL TDAFENEYVPAYYVFDKTGQLRHFQAGGSGMKMLEKRVNRVLAETE*" /label="ykuV CDS" gene 1338937..1339383 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /label="ykuV gene" downshifts 1339391 /Source="Nicolas_upshifts" /id="D796" /incds=0 /nref=58 /ntot=211 /MaxReadThrough="3.11112" /MaxDrop="4.73023" /score="10.8864177" /energy="-5.4" /TU="U1175" /idTUdmin="U1172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1339776..1339783 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1339796 /Source="Nicolas_upshifts" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1339798..1339817 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1339849..1340424 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 27902860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 27902860; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of comK" /protein_id="NP_389307.1" /db_xref="EnsemblGenomes-Gn:BSU14240" /db_xref="EnsemblGenomes-Tr:CAB13297" /db_xref="GOA:O34857" /db_xref="SubtiList:BG13307" /db_xref="UniProtKB/Swiss-Prot:O34857" /translation="MFNEREALRLRLEQLNEAEVKVIREYQIERDKIYAKLRELDRNG SPSEIKKDFRSEKKPDSLPVLAELAAQEIRSYQPQSQQQSVQPQLQSISSLPAGIPDG TTRRRRGTARPGSKAAKLREAAIKTLKRHNAAIKSSELQKEIEKESGLEIPNMTTFMQ SLIKMYPEVKKPYRGQYILEGEIESAESANE*" /label="rok CDS" gene 1339849..1340424 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /label="rok gene" downshifts 1340402 /Source="Nicolas_upshifts" /id="D797" /incds=0 /nref=246 /ntot=258 /MaxReadThrough="1.77207" /MaxDrop="6.35121" /score="17.7584572" /energy="-9" /TU="NA" /idTUdmin="U1176" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1340465..1341430) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /experiment="publication(s) with functional evidences, PMID:8990290, 15383836, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 15383836, 15743949; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein cse15" /protein_id="NP_389308.1" /db_xref="EnsemblGenomes-Gn:BSU14250" /db_xref="EnsemblGenomes-Tr:CAB13298" /db_xref="GOA:O31700" /db_xref="SubtiList:BG12251" /db_xref="UniProtKB/Swiss-Prot:O31700" /translation="MKRSGPFFHDVSQENLYLKSELSRCHKLISELEASYFHQKNNKL LKENTDMKEKLQQLSAELTHMSTKEKHASHTSQTLHQIRAELLDKIVVLQELLSAETY KRRAEIEEKHKLHIAKVKIEEENKNLHKRISELQASIEQEQNALLQAKQQAELIKAEN GRLKEQMVEKEYQLKHIKIEVDHMKDRIIETKERLLDIEKTKEKLFHETIISYKRQLD ESDAWIASHFADIDGGTKQKEKTEEEAPAAYAQPNHVETILEDVTKQIHVLQKQLAHA QSSDQAKSHTIEELKNRAAEEKPYQKWVYKLNLEKENKPSQKKPQ*" /label="sppO CDS" gene complement(1340465..1341430) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /label="sppO gene" downshifts complement(1340478) /Source="Nicolas_upshifts" /id="D798" /incds=0 /nref=47 /ntot=67 /MaxReadThrough="2.24884" /MaxDrop="5.5936" /score="3.60334458" /energy="-7.2" /TU="NA" /idTUdmin="U1178" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1340774..1340775 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1340793..1340812 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1340799..1341523 /Source="Nicolas_S_feature" /locus_tag="new_1494737_1495461" /HighExp="dia15, Diami, dia5, H2O2, G135, G150, G180, LBGexp, Paraq, Lbexp" /AntisenseName="yknT" /AntisenseCor="-0.36512493899072102" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S520" upshifts 1340799 /Source="Nicolas_upshifts" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1341451..1341469) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1341472) /Source="Nicolas_upshifts" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1341484..1341489) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1341510..1341516 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1341526 /Source="Nicolas_upshifts" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1341530..1341549 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1341567..1342166 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /EC_number="2.7.7.77" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10978347; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein A" /protein_id="NP_389309.1" /db_xref="EnsemblGenomes-Gn:BSU14260" /db_xref="EnsemblGenomes-Tr:CAB13299" /db_xref="GOA:O31701" /db_xref="InterPro:IPR013482" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12621" /db_xref="UniProtKB/Swiss-Prot:O31701" /translation="MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVI ISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQR RTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRI SVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD*" /label="mobA CDS" gene 1341567..1342166 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /label="mobA gene" CDS 1342217..1343236 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /EC_number="2.7.7.80" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17223713; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin biosynthesis adenylyltransferase" /protein_id="NP_389310.1" /db_xref="EnsemblGenomes-Gn:BSU14270" /db_xref="EnsemblGenomes-Tr:CAB13300" /db_xref="GOA:O31702" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG12624" /db_xref="UniProtKB/Swiss-Prot:O31702" /translation="MEERYSRQIRFKQIGEEGQKRLADSHVLIVGAGALGTAGAEGLS RAGVGTITIIDRDYVEWSNLQRQQLYTESDAKLRMPKAMAAKEHLSAINSEIHIEAYV TEGTAETLEPLIEKADVVIDATDNFETRMLINDLAQKTKTPWVYGACVSSQGMFMTVI PGETPCLSCLFEQIPVGGATCDTAGIIPPAVHIVSAYQQAEALKLLTGQKEAIQRGFV TFDVWNNSHMKINVNHVRREECPSCGANAVYPYLQDWNTPKAAVLCGRDTVQVRSESL KRIPKQELIKRLKTIGKVEANAFLLHIFYEDFRIVIFNDGRALVHGTNDVKEANSVLA RVIGL*" /label="moeB CDS" gene 1342217..1343236 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /label="moeB gene" CDS 1343254..1344546 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /EC_number="2.10.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11428898, 12006571, 18959753, 21206014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdate to molybdopterin ligation enzyme" /protein_id="NP_389311.1" /db_xref="EnsemblGenomes-Gn:BSU14280" /db_xref="EnsemblGenomes-Tr:CAB13301" /db_xref="GOA:O31703" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR005110" /db_xref="InterPro:IPR005111" /db_xref="InterPro:IPR036135" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036688" /db_xref="SubtiList:BG12623" /db_xref="UniProtKB/Swiss-Prot:O31703" /translation="MLEKRTPIPVDEAVRRVCHFQKQGETEWVALEDSLHRFLAEDIT ADHHVPAFDRSPYDGFAVRACDTAEASRENPVRFEVIDHIGAGAVSEKELGPFQAVRI MTGAQIPEGADAVVMIELTQAFEENGKSFMSLKRRFQTGDNISKTGEDAQKGSVLLTK GTRVTPGVTALLATFGYASVPVVRKPVVGIIATGTELLNVSDPLEPGKIRNSNASMVY AQAIEAGATPLYLGKISDELDKSFAAVKEAMKKVDFLITTGGVSVGDFDFLPAIYEKL GADVLFNKVAMRPGSVTTVAHANDMLLFGLSGNPSACYVGFELFVKPIIQTWLLNETP HSICAEAVLTKDFPKPNPFTRFVRALVHHQEGKLLATPVGLDKSSSVTSLADANAFII LPGGTRGYESGRTVQVLLIREENGSEWPWSVLSRSSKL*" /label="moeA CDS" gene 1343254..1344546 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /label="moeA gene" CDS 1344507..1345028 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9219527, 12682065, 12719427; Product type c: carrier" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein B" /protein_id="NP_389312.1" /db_xref="EnsemblGenomes-Gn:BSU14290" /db_xref="EnsemblGenomes-Tr:CAB13302" /db_xref="GOA:O31704" /db_xref="InterPro:IPR004435" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12622" /db_xref="UniProtKB/Swiss-Prot:O31704" /translation="MALVRPFPIVQVVGFQNSGKTTFIERILEKASEQGVHLGCLKHH GHGGEPQTLTEGKDTDRYKAAGADVTAVEGAGVLQLTARRNWDLARLIELYQFLETDC LLIEGFKKAPYPKVVILSEKEDLEALQAVNIIAIIYRKKEHMTEHQGLPVFHADDPVA VDFVLSQLKGESA*" /label="mobB CDS" gene 1344507..1345028 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /label="mobB gene" CDS 1345028..1345501 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /EC_number="2.8.1.12" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 18092812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (large subunit)" /protein_id="NP_389313.1" /db_xref="EnsemblGenomes-Gn:BSU14300" /db_xref="EnsemblGenomes-Tr:CAB13303" /db_xref="GOA:O31705" /db_xref="InterPro:IPR003448" /db_xref="InterPro:IPR036563" /db_xref="SubtiList:BG12620" /db_xref="UniProtKB/Swiss-Prot:O31705" /translation="MERFEITKTPINTENIIKKVEKREAGAITTFIGTVREWTNGKRT VRLEYEAYEPMAVQMLAQIGAEIEEKWEGASAAITHRIGVLDIGEAAVVIAVSSPHRK AAYEANEYAIERIKQIVPIWKKEIWEDGEQWIGDQLETTAYPNGKPDLSEGEQHD*" /label="moaE CDS" gene 1345028..1345501 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /label="moaE gene" CDS 1345494..1345727 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 17223713, 19946146; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (small subunit)" /protein_id="NP_389314.1" /db_xref="EnsemblGenomes-Gn:BSU14310" /db_xref="EnsemblGenomes-Tr:CAB13304" /db_xref="GOA:O31706" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010034" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="SubtiList:BG12619" /db_xref="UniProtKB/Swiss-Prot:O31706" /translation="MIKILLFAGLAEQAGTQAIEIDMEQATTDEIKASLKEQYGLESI DTAMIAVNESYVKENTSVSSGDTVAIIPPVSGG*" /label="moaD CDS" gene 1345494..1345727 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /label="moaD gene" downshifts 1345706 /Source="Nicolas_upshifts" /id="D799" /incds=0 /nref=87 /ntot=240 /MaxReadThrough="1.14308" /MaxDrop="5.73073" /score="32.0123217" /energy="-16.9" /TU="NA" /idTUdmin="U1177" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1345772..1345777 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-35" promotor_-10 1345794..1345812 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-10" upshifts 1345802 /Source="Nicolas_upshifts" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="upshifts" S_feature 1345814..1345900 /Source="Nicolas_S_feature" /locus_tag="new_1499752_1499838" /HighExp="S4, S5, S3, T5.0H, T4.0H, Pyr, S6, T3.30H, M9-stat, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S521" promotor_-35 1345890..1345893 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1345902 /Source="Nicolas_upshifts" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1345908..1345927 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1345951..1347708 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389315.1" /db_xref="EnsemblGenomes-Gn:BSU14320" /db_xref="EnsemblGenomes-Tr:CAB13305" /db_xref="GOA:O31707" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13241" /db_xref="UniProtKB/Swiss-Prot:O31707" /translation="METFKRLKMYYWPYRKVFMWSLLAMLLMTAITVVYPIILQITID EIVLGRQYQLAAWVSLGFIAVMVLKGMATFFHQYLGDMFGIKSVYRLRNGLYEKLQRL SFSYYDNAKTGDLMSRLTADVEGLRFFLSYGLAELIRFGLLVAISLSVMFYYSVPLTL VTIAVLPFLAVAVYRFDKRVHPAFRGIRKSFAKLNTKVQENISGINTVKSLSREDFQI STFNKANAEYRAQYLQTSSIWSAYFPLMEFIGNTCIVALLSYGGYLVMQNQLNPGELV AFFSLVNYMMWPIMNLGFVINMFSQAKASGERLLDILEKEEDITDHPHALHKQKLTGD VHFKNVSLAYGKEQTNALCNVSFEANSGKVIGLLGPTGSGKSSVTQLLTRFYSPVGGM ITIDHKPITDYSLKTLRSNIGVVLQESFLFSSTIRSNISYGRPDASMEDVIEAAKRAQ AHNFIMELPDGYDTMLGERGMGLSGGQKQRIAIARAICLNPSILILDDATSAVDMQTE HSIQLALKEVMKNRTTFIVAHRISSLKHADEILVFNKGRIRERGTHHELLEKGGYYKK IYDLQYRDVKMINEPHEVG*" /label="yknU CDS" gene 1345951..1347708 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /label="yknU gene" CDS 1347720..1349534 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389316.1" /db_xref="EnsemblGenomes-Gn:BSU14330" /db_xref="EnsemblGenomes-Tr:CAB13306" /db_xref="GOA:O31708" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13242" /db_xref="UniProtKB/Swiss-Prot:O31708" /translation="MKQAKKQGVLERFYYSSDEIIEKPFNWAQMWRLLSYVKPYRKTI LPLSFLTVLIGTAVKLVIPILIGVYVLDQAITGRNSELLIQLIFIISGLYVLNYAANV LRIRWMNQLGQHVIYDLRQHLFTHVQRLSHRFFDQRSAGSILVRIMNDINSLQELFTS GVINLLTDLLLLAGVIIILFTLSPELTIAIMVTLPIMFFISTSLRKKIRRSWQTVRLK QSKLNSHLNESIQGIRVTQAFTQEEENMAYFDGVNQENYESWREATRKNAMFRPLVEM TNAIGTAVLIWYGATLIMNETITIGVFVSFAFYLGMFWEPISRLGQVYNQLLMGMASS ERIFEFLDEQPNVKEKPNAIHNEKINGEISFEEVEFSYDEKRKALHAVSFSIPAGSTL ALVGHTGSGKTTIANLISRFYDAAGGTIKIDGIPIKDLSLASLRSQISIVLQDTFIFS GTIMENIRFGRPNASDEEVMKASQAVGADEFISDLAEGYATEVEERGSVLSAGQRQLI SFARALLADPAIIILDEATASIDTETEVKIQQALKTLLKGRTAVMIAHRLSTIRDADR IIVLDHGRKIEEGNHDQLLAKGGIYAGLVKAQYSTAIE*" /label="yknV CDS" gene 1347720..1349534 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /label="yknV gene" promotor_-10 complement(1348157..1348176) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1348167) /Source="Nicolas_upshifts" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1348191..1348198) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1349585..1349594 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1349606..1349621 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1349610 /Source="Nicolas_upshifts" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="upshifts" CDS 1349644..1350339 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of permease exporting the starvation-induced killing protein" /protein_id="NP_389317.1" /db_xref="EnsemblGenomes-Gn:BSU14340" /db_xref="EnsemblGenomes-Tr:CAB13307" /db_xref="GOA:O31709" /db_xref="InterPro:IPR006977" /db_xref="SubtiList:BG13243" /db_xref="UniProtKB/Swiss-Prot:O31709" /translation="METNVEKNSGTATEKPSLFGVITSPSVQFERIRERPAVWGPLLI VAAIIIVGAVLQSLGTDYSELLKSQDTQGLSAEQMETVATITKFGGMAGAIIGGIAAL FIAPLIYWLCVKVSGGVTTYKKMLSLSLFVSLISSLGLLVNGIVAFTTDVNPLYSTTS LAGIIPSDGALASVLNTFEIFSIWSFVLLAIGLHKTGGISKKAGWISAIILFGILVVF SLFSGLINSVAGA*" /label="skiW CDS" gene 1349644..1350339 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /label="skiW gene" CDS 1350344..1351477 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11544226, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544226, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein" /protein_id="NP_389318.1" /db_xref="EnsemblGenomes-Gn:BSU14350" /db_xref="EnsemblGenomes-Tr:CAB13308" /db_xref="GOA:O31710" /db_xref="InterPro:IPR006143" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG13244" /db_xref="UniProtKB/Swiss-Prot:O31710" /translation="MKKVWIGIGIAVIVALFVGINIYRSAAPTSGSAGKEVQTGSVEE NEISSTVMVPGTLKFSNEQYVFYEADKGTLEDIKVKEGDKVKKGTALVTYTNEQLSLE KEQNQLTSESNRLQIDQIQEKLKALDSKERELEKQVGKKEAEKQIESERTELQMQKKT AEIELKQTELQRQSLANRVSDLEVKSEIEGTVISVNQEAASKKSDIQEPVIHIGNPKD LVVSGKLSEYDTLKVKKGQKVTLTSDVIQGKTWKGTVSAVGLVPDQQESAAAQGTEQA VQYPLQVKIKGNLPEGKPGFKFIMNIETDKRKANTLPSKAVKKEDDQYYVYTVKDGKA KRVDVKIGEVTDDLTEIKEGLTQDDQVILNPSDQVTDGMEVKS*" /label="skiX CDS" gene 1350344..1351477 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /label="skiX gene" CDS 1351478..1352170 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein (ATP-binding protein)" /protein_id="NP_389319.1" /db_xref="EnsemblGenomes-Gn:BSU14360" /db_xref="EnsemblGenomes-Tr:CAB13309" /db_xref="GOA:O31711" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13245" /db_xref="UniProtKB/Swiss-Prot:O31711" /translation="MIQLSNVRKSYQIGKETFDVLHSIDLDIHQGEYVSIMGPSGSGK STIMNIIGCLDRPTSGTYQLDGEDISSYKDKELAAVRNRSIGFVFQQFQLLPRLNAKK NVELPMIYSGIGKKERQERAERALEKVGLADRMLHMPNELSGGQKQRVAIARAIVNEP KLILADEPTGALDTKTSEAIMDQFTALNAEGTTIVLVTHEPEVADCTNRIVMVRDGNI VPASSGQRSVGE*" /label="skiY CDS" gene 1351478..1352170 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /label="skiY gene" CDS 1352167..1353360 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703, 22720735, 27243566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703, 22720735, 27243566; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease subunit exporting Sporulation-Delaying Protein" /protein_id="NP_389320.1" /db_xref="EnsemblGenomes-Gn:BSU14370" /db_xref="EnsemblGenomes-Tr:CAB13310" /db_xref="GOA:O31712" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR005085" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13246" /db_xref="UniProtKB/Swiss-Prot:O31712" /translation="MSLLENIRMALSSVLAHKMRSILTMLGIIIGVGSVIVVVAVGQG GEQMLKQSISGPGNTVELYYMPSDEELASNPNAAAESTFTENDIKGLKGIEGIKQVVA STSESMKARYHEEETDATVNGINDGYMNVNSLKIESGRTFTDNDFLAGNRVGIISQKM AKELFDKTSPLGEVVWINGQPVEIIGVLKKVTGLLSFDLSEMYVPFNMMKSSFGTSDF SNVSLQVESADDIKSAGKEAAQLVNDNHGTEDSYQVMNMEEIAAGIGKVTAIMTTIIG SIAGISLLVGGIGVMNIMLVSVTERTREIGIRKSLGATRGQILTQFLIESVVLTLIGG LVGIGIGYGGAALVSAIAGWPSLISWQVVCGGVLFSMLIGVIFGMLPANKAAKLDPIE ALRYE*" /label="skiZ CDS" gene 1352167..1353360 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /label="skiZ gene" downshifts 1353338 /Source="Nicolas_upshifts" /id="D800" /incds=0 /nref=79 /ntot=210 /MaxReadThrough="3.49546" /MaxDrop="4.46952" /score="36.2703425" /energy="-12.1" /TU="U1183" /idTUdmin="U1183" /TUdmin="-396" /isTUend="FALSE" /label="downshifts" promotor_-35 1353409..1353415 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1353429..1353440 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1353437 /Source="Nicolas_upshifts" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1353482..1353489 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-35" promotor_-10 1353504..1353523 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-10" S_feature 1353509..1353600 /Source="Nicolas_S_feature" /locus_tag="new_1507447_1507538" /HighExp="UNK1, LPh, HPh, Fru, G180, MG 5, C30, G135, MG t5, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigWXY" /TUshortPSig="0.967, 0.86, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S522" upshifts 1353509 /Source="Nicolas_upshifts" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="upshifts" promotor_-35 1353564..1353571 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1353585..1353604 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1353602 /Source="Nicolas_upshifts" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="upshifts" CDS 1353640..1354395 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563858; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (DeoR family)" /protein_id="NP_389321.1" /db_xref="EnsemblGenomes-Gn:BSU14380" /db_xref="EnsemblGenomes-Tr:CAB13311" /db_xref="GOA:O31713" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12589" /db_xref="UniProtKB/Swiss-Prot:O31713" /translation="MLTPERHQLIIDQIEKHDVVKIQELINLTNASESTIRRDLSTLE ERGFLKRVHGGAAKLSDIRLEPDMLEKSSKNLHDKLKIAEKAASLLEEGDCIYLDAGT TTLHMIDFMDKTKDIVVVTNGVMHIDALIRKEISFYLLGGYVKHRTGAIIGGASLVAM DQYRFDKSFLGTNGVHTEAGFTTPDPDEALLKQKAIKQAKHAYVLADPSKFGEISFSA FAGIGDATIITTDAEELTFDNYQEKTVVKVVKP*" /label="fruR CDS" gene 1353640..1354395 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /label="fruR gene" upshifts complement(1353788) /Source="Nicolas_upshifts" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1353790..1353792) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1354392..1355303 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /EC_number="2.7.1.56" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 168069, 14563858, 24328040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1-phosphate kinase" /protein_id="NP_389322.1" /db_xref="EnsemblGenomes-Gn:BSU14390" /db_xref="EnsemblGenomes-Tr:CAB13312" /db_xref="GOA:O31714" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR017583" /db_xref="InterPro:IPR022463" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12588" /db_xref="UniProtKB/Swiss-Prot:O31714" /translation="MIYTVTLNPSVDYIVHVEDFTVGGLNRSSYDTKYPGGKGINVSR LLKRHHVASKALGFVGGFTGEYIKTFLREENLETAFSEVKGDTRINVKLKTGDETEIN GQGPTISDEDFKAFLEQFQSLQEGDIVVLAGSIPSSLPHDTYEKIAEACKQQNARVVL DISGEALLKATEMKPFLMKPNHHELGEMFGTAITSVEEAVPYGKKLVEQGAEHVIVSM AGDGALLFTNEAVYFANVPKGKLVNSVGAGDSVVAGFLAGISKQLPLEEAFRLGVTSG SATAFSEELGTEEFVQQLLPEVKVTRL*" /label="fruK CDS" gene 1354392..1355303 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /label="fruK gene" CDS 1355318..1357225 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /EC_number="2.7.1.202" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:118007, 200418" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 118007, 200418; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIABC component" /protein_id="NP_389323.1" /db_xref="EnsemblGenomes-Gn:BSU14400" /db_xref="EnsemblGenomes-Tr:CAB13313" /db_xref="GOA:P71012" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R4Q" /db_xref="SubtiList:BG11938" /db_xref="UniProtKB/Swiss-Prot:P71012" /translation="MKITELLTKHTIKLNIESKEKENVIDEMVTVLDKAGKLNDRQAY KEAILNRESQSSTGIGEGIAIPHAKTASVINPAIAFGRSKDGVDYESLDGQPAHLVFM IAATEGANNTHLEALSRLSTLLMREEIRKQLLEAESEDAIIDIINQHDKDDDEEEEEE EAAPAPAGKGKILAVTACPTGIAHTFMAADALKEKAKELGVEIKVETNGSSGIKHKLT AQEIEDAPAIIVAADKQVEMERFKGKRVLQVPVTAGIRRPQELIEKAMNQDAPIYQGS GGGSAASNDDEEAKGKSGSGIGNTFYKHLMSGVSNMLPFVVGGGILVAISFFWGIHSA DPNDPSYNTFAAALNFIGGDNALKLIVAVLAGFIAMSIADRPGFAPGMVGGFMATQAN AGFLGGLIAGFLAGYVVILLKKVFTFIPQSLDGLKPVLIYPLFGIFITGVLMQFVVNT PVAAFMNFLTNWLESLGTGNLVLMGIILGGMMAIDMGGPLNKAAFTFGIAMIDAGNYA PHAAIMAGGMVPPLGIALATTIFRNKFTQRDREAGITCYFMGAAFVTEGAIPFAAADP LRVIPAAVVGAAVAGGLTEFFRVTLPAPHGGVFVAFITNHPMLYLLSIVIGAVVMAII LGIVKKPVTEK*" /label="fruA CDS" gene 1355318..1357225 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /label="fruA gene" downshifts 1357210 /Source="Nicolas_upshifts" /id="D801" /incds=0 /nref=133 /ntot=228 /MaxReadThrough="3.99928" /MaxDrop="5.27169" /score="11.7516734" /energy="-11.4" /TU="U1185" /idTUdmin="U1186" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1357294..1357301 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1357312..1357331 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1357315 /Source="Nicolas_upshifts" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="upshifts" CDS 1357370..1357951 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11283286, 11807061, 12897006, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11283286, 11807061, 12897006, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_389324.1" /db_xref="EnsemblGenomes-Gn:BSU14410" /db_xref="EnsemblGenomes-Tr:CAB13314" /db_xref="GOA:P71013" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11977" /db_xref="UniProtKB/Swiss-Prot:P71013" /translation="MTEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEP YLVEGSSMYPTLHDGERLFVNKTVNYIGELKRGDIVIINGETSKIHYVKRLIGKPGET VQMKDDTLYINGKKVAEPYLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNS MDSRNGLGLIAEDRIVGTSKFVFFPFNEMRQTK*" /label="sipT CDS" gene 1357370..1357951 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /label="sipT gene" downshifts 1357936 /Source="Nicolas_upshifts" /id="D802" /incds=0 /nref=90 /ntot=226 /MaxReadThrough="3.7981" /MaxDrop="6.13957" /score="5.03270493" /energy="-9.8" /TU="U1188" /idTUdmin="U1188" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1357980 /Source="Nicolas_upshifts" /id="D803" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.6676" /MaxDrop="3.60225" /score="5.03270493" /energy="-9.8" /TU="NA" /idTUdmin="U1188" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1357985..1358254) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389325.1" /db_xref="EnsemblGenomes-Gn:BSU14420" /db_xref="EnsemblGenomes-Tr:CAB13315" /db_xref="GOA:O31715" /db_xref="SubtiList:BG13247" /db_xref="UniProtKB/Swiss-Prot:O31715" /translation="MRLLTLTEYCLLIFFTGFYLAVTGFTAKDIGLYIGIALIYIFSH IFSKRLLEKRGKENKQVHLFFSVLAIIGSVFITVLCIALVASFSK*" /label="ykoA CDS" gene complement(1357985..1358254) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /label="ykoA gene" downshifts complement(1357990) /Source="Nicolas_upshifts" /id="D804" /incds=0 /nref=38 /ntot=254 /MaxReadThrough="2.08491" /MaxDrop="5.70938" /score="11.210199" /energy="-9.8" /TU="U1189" /idTUdmin="U1189" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(1358255..1358320) /Source="Nicolas_S_feature" /locus_tag="new_1512193_1512258_c" /HighExp="LoTm, Gly, Lbstat, Sw, Cold, C30, HPh, S0, T0.30H, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S523" misc_feature complement(1358301..1358320) /Source="Nicolas_upshift_promotors" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1358320) /Source="Nicolas_upshifts" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1358373..1358380 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1358391..1358410 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1358395 /Source="Nicolas_upshifts" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="upshifts" CDS 1358435..1360057 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10816464, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_389326.1" /db_xref="EnsemblGenomes-Gn:BSU14430" /db_xref="EnsemblGenomes-Tr:CAB13316" /db_xref="GOA:O31716" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG13270" /db_xref="UniProtKB/Swiss-Prot:O31716" /translation="MIAVNNVSLRFADRKLFEDVNIKFTPGNCYGLIGANGAGKSTFL KVLSGEIEPQTGDVHMSPGERLAVLKQNHFEYEEYEVLKVVIMGHKRLYEVMQEKDAI YMKPDFSDEDGIRAAELEGEFAELNGWEAESEAAILLKGLGISEDLHTKKMADLGGSE KVKVLLAQALFGKPDVLLLDEPTNHLDLQAIQWLEEFLINFENTVIVVSHDRHFLNKV CTHIADLDFNKIQIYVGNYDFWYESSQLALKLSQEANKKKEEQIKQLQEFVARFSANA SKSKQATSRKKLLEKITLDDIKPSSRRYPYVNFTPEREIGNDVLRVEGLTKTIDGVKV LDNVSFIMNREDKIAFTGRNELAVTTLFKIISGEMEADSGTFKWGVTTSQAYFPKDNS EYFEGSDLNLVDWLRQYSPHDQSESFLRGFLGRMLFSGEEVHKKANVLSGGEKVRCML SKAMLSGANILILDEPTNHLDLESITALNNGLISFKGAMLFTSHDHQFVQTIANRIIE ITPNGIVDKQMSYDEFLENADVQKKLTELYAE*" /label="ykpA CDS" gene 1358435..1360057 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /label="ykpA gene" downshifts 1360045 /Source="Nicolas_upshifts" /id="D805" /incds=0 /nref=45 /ntot=239 /MaxReadThrough="5.13671" /MaxDrop="3.6227" /score="17.6386925" /energy="-7.6" /TU="U1190" /idTUdmin="U1190" /TUdmin="-993" /isTUend="FALSE" /label="downshifts" CDS 1360114..1361025 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 15966718, 17229734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate reductase" /protein_id="NP_389327.1" /db_xref="EnsemblGenomes-Gn:BSU14440" /db_xref="EnsemblGenomes-Tr:CAB13317" /db_xref="GOA:O31717" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13271" /db_xref="UniProtKB/Swiss-Prot:O31717" /translation="MKFLVVGAGGVGGYIGGRLSEKGNDVTFLVRQKRAEQLKKTGLV IHSEKGNVSFQPELISAGETGQFDVVIIASKAYSLGQVIEDVKPFIHQESVIIPFLNG YRHYEQLFAAFSKEQVLGGLCFIESALDNKGEIHHTSASHRFVFGEWNGERTERIRAL EEAFSGVKAEVIISGHIEKDIWKKYLFIAAQAGITTLFQRPLGPILATEAGRHTAQTL IGEICTVLRKEGVPADPALEEESFRTMTSMSYHMKSSMLRDMENGQTTEGDHLHGFLI EKAKRLSLAAPVLETVYANLQMYEAEK*" /label="panE CDS" gene 1360114..1361025 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /label="panE gene" downshifts 1361030 /Source="Nicolas_upshifts" /id="D806" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="2.04919" /MaxDrop="4.55439" /score="11.4959806" /energy="-9.6" /TU="NA" /idTUdmin="U1190" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1361059..1362291) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /EC_number="3.4.11.24" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9362117, 16088219, 22808738" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9362117, 16088219, 22808738; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase" /protein_id="NP_389328.1" /db_xref="EnsemblGenomes-Gn:BSU14450" /db_xref="EnsemblGenomes-Tr:CAB13318" /db_xref="GOA:P39762" /db_xref="InterPro:IPR000787" /db_xref="InterPro:IPR035097" /db_xref="SubtiList:BG10986" /db_xref="UniProtKB/Swiss-Prot:P39762" /translation="MDSFSQKLNTYAQLAVEVGVNVQKGQYVVVNASTDVRDFVRLIV KHAYEKGAKNVTVNWQDDEVAKLKYELAPFEAFEEYPEWEAKGREELAKNGAAFISVV SSNPDLLKGIDSKRIAAFQKAAGKALHTYRQYIQSDKVSWTVVGAASAGWAHKVFPGK SEEEAIHLLWEEIFKATRVNEDNPVQAWINHDQNLHEKVDHLNERHYAALHYQAEGTD LTIKLPRKHVWAGAGSVNESGHEFMANMPTEEVFTLPQKDGVDGVVSSTKPLSYGGNI IENFTLTFENGRIVDIKAEKGEDILKELVETDEGSHYLGEVALVPYDSPISQSNILFY NTLFDENASNHLAIGSAYAFNIEGGKQMSREELVKEGLNESITHVDFMIGSKDMNIDG ITADGKREPIFRNGNWAF*" /label="ampS CDS" gene complement(1361059..1362291) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /label="ampS gene" downshifts complement(1361070) /Source="Nicolas_upshifts" /id="D807" /incds=0 /nref=215 /ntot=254 /MaxReadThrough="1.34101" /MaxDrop="5.7635" /score="40.7811053" /energy="-9.6" /TU="NA" /idTUdmin="U1191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1362309..1362328) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1362333) /Source="Nicolas_upshifts" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1362343..1362348) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1362401..1362535) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389329.1" /db_xref="EnsemblGenomes-Gn:BSU14460" /db_xref="EnsemblGenomes-Tr:CAB13319" /db_xref="InterPro:IPR035379" /db_xref="SubtiList:BG11812" /db_xref="UniProtKB/Swiss-Prot:Q45492" /translation="MLRDLGRRVAIAAILSGIILGGMSISLANMPHSPAGGTVKLNHP *" /label="ykpC CDS" gene complement(1362401..1362535) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /label="ykpC gene" downshifts complement(1362412) /Source="Nicolas_upshifts" /id="D808" /incds=0 /nref=51 /ntot=151 /MaxReadThrough="3.10365" /MaxDrop="5.04142" /score="-2.2377884" /energy="-9.1" /TU="U1192" /idTUdmin="U1193" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1362557..1362575) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1362568) /Source="Nicolas_upshifts" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1362570..1362635) /Source="Nicolas_S_feature" /locus_tag="new_1516508_1516573_c" /HighExp="HiTm, C30, Lbstat, MG-0.2, BC, G135, MG 15, MG 10, MG-0.1, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S524" promotor_-35 complement(1362591..1362596) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1362636..1363643) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16950129, 19643765, 19659933, 21091501, 21636651, 26091431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950129, 19643765, 19659933, 21091501, 21636651, 26091431; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_389330.1" /db_xref="EnsemblGenomes-Gn:BSU14470" /db_xref="EnsemblGenomes-Tr:CAB13320" /db_xref="GOA:P39763" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10987" /db_xref="UniProtKB/Swiss-Prot:P39763" /translation="MFQSTEIGIDLGTANILVYSKNKGIILNEPSVVAVDTTTKAVLA IGADAKNMIGKTPGKIVAVRPMKDGVIADYDMTTDLLKHIMKKAAKSIGMSFRKPNVV VCTPSGSTAVERRAISDAVKNCGAKNVHLIEEPVAAAIGADLPVDEPVANVVVDIGGG TTEVAIISFGGVVSCHSIRIGGDQLDEDIVSFVRKKYNLLIGERTAEQVKMEIGHALI EHIPEAMEIRGRDLVTGLPKTIMLQSNEIQDAMRESLLHILEAIRATLEDCPPELSGD IVDRGVILTGGGALLNGIKEWLTEEIVVPVHVAQNPLESVAIGTGRSLEVIDKLQKAI K*" /label="mreBH CDS" gene complement(1362636..1363643) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /label="mreBH gene" upshifts complement(1363689) /Source="Nicolas_upshifts" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1363690..1363698) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1363712..1363720) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1363830..1363839 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-35" upshifts 1363851 /Source="Nicolas_upshifts" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="upshifts" promotor_-10 1363852..1363867 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-10" S_feature 1363854..1363926 /Source="Nicolas_S_feature" /locus_tag="new_1517792_1517864" /HighExp="Lbexp, dia5, LBGexp, dia0, Lbtran, Mt0, Oxctl, Paraq, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S525" CDS 1363927..1364205 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16159768, 17720793, 19767430, 20817675, 20844865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159768, 17720793, 19767430, 20817675, 20844865; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389331.1" /db_xref="EnsemblGenomes-Gn:BSU14480" /db_xref="EnsemblGenomes-Tr:CAB13321" /db_xref="GOA:P39758" /db_xref="InterPro:IPR007159" /db_xref="PDB:2FY9" /db_xref="PDB:2RO3" /db_xref="SubtiList:BG10988" /db_xref="UniProtKB/Swiss-Prot:P39758" /translation="MKSIGVVRKVDELGRIVMPIELRRALDIAIKDSIEFFVDGDKII LKKYKPHGVCLMTGEITSENKEYGNGKITLSPEGAQLLLEEIQAALKE*" /label="abhA CDS" gene 1363927..1364205 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /label="abhA gene" downshifts 1364203 /Source="Nicolas_upshifts" /id="D809" /incds=0 /nref=61 /ntot=238 /MaxReadThrough="4.68201" /MaxDrop="5.62457" /score="7.91393519" /energy="-11" /TU="U1194" /idTUdmin="U1194" /TUdmin="-135" /isTUend="FALSE" /label="downshifts" S_feature complement(1364237..1365866) /Source="Nicolas_S_feature" /locus_tag="new_1518175_1519804_c" /HighExp="S6, S8, S5, LoTm, S4, S7, S3, C30, T5.0H, BT" /AntisenseName="kinC" /AntisenseCor="-0.76370141168998495" /AntisenseRegPval="-51.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S526" S_feature 1364248..1364352 /Source="Nicolas_S_feature" /locus_tag="new_1518186_1518290" /HighExp="Oxctl, Lbexp, LBGexp, H2O2, dia0, Paraq, G180, G150, G135, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S527" downshifts complement(1364260) /Source="Nicolas_upshifts" /id="D810" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.833919999999999" /MaxDrop="3.11258" /score="8.02057524" /energy="-11" /TU="NA" /idTUdmin="U1196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1364334..1364341 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1364353..1364372 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1364354 /Source="Nicolas_upshifts" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="upshifts" CDS 1364395..1365681 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /EC_number="2.7.13.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-responsive histidine kinase regulating cannibalism and biofilm formation" /protein_id="NP_389332.1" /db_xref="EnsemblGenomes-Gn:BSU14490" /db_xref="EnsemblGenomes-Tr:CAB13322" /db_xref="GOA:P39764" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10989" /db_xref="UniProtKB/Swiss-Prot:P39764" /translation="MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAV TLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEKNRIMDNLQEIVFQTNAKGEITY LNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGT IFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSEL AAGIAHEVRNPLTSVSGFLQIMKTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQA ITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMINGDENQLKQVFINIIK NGIEAMPKGGVVTISTAKTASHAVISVKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGL PICLRILKEHDGELKIESEAGKGSVFQVVLPLKSDS*" /label="kinC CDS" gene 1364395..1365681 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /label="kinC gene" CDS 1365697..1366530 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /EC_number="2.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28537416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative gamma-glutamylcyclotransferase (bacillithiol degradation)" /protein_id="NP_389333.1" /db_xref="EnsemblGenomes-Gn:BSU14500" /db_xref="EnsemblGenomes-Tr:CAB13323" /db_xref="GOA:P39759" /db_xref="InterPro:IPR009288" /db_xref="InterPro:IPR013024" /db_xref="InterPro:IPR036568" /db_xref="PDB:2QIK" /db_xref="SubtiList:BG10990" /db_xref="UniProtKB/Swiss-Prot:P39759" /translation="MNSLLFVYGTLRKHEKNHHLLAQSACINEQARTKGSLFAAKEGP TVVFNDEDEGYIYGEVYEADELCIHKLDQFFQGYHKQTVFVETDVGIKIALIYFMNKD GCAGFTKISSGDWKEHQMISKSKNPIYYFAYGSCMDNARFQKAGVDHYFQDPVGRAVL KGYTTRFTLKREDGSRADMLEDGGTTEGVLYRIPYSALSYLYKREGVESLTYRPAFVD VEAGGRHYKDCLTFLVLQKEAEIAPPQHYQIEIERGAELYLSPEFTEKLKRHMNSLPK G*" /label="ykqA CDS" gene 1365697..1366530 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /label="ykqA gene" promotor_-10 complement(1365863..1365881) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1365878) /Source="Nicolas_upshifts" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1365897..1365902) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1366593..1367258 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 22720735, 23963175, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 22720735, 23963175, 28420751; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_389334.1" /db_xref="EnsemblGenomes-Gn:BSU14510" /db_xref="EnsemblGenomes-Tr:CAB13324" /db_xref="GOA:P39760" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG10991" /db_xref="UniProtKB/Swiss-Prot:P39760" /translation="MKKEFAVIGLGRFGGSICKALSEEGVEVMAMDIDEDKVNEYAKI ASHAVIGDSTDESVLKNLGLRNFDHVIVAIGENIQASILTTLILKELGVHTITVKAQN DYHEKVLSKIGADHIVHPERDMAKRIAHNIVSNNVLDYLELSEEHSLVEIVANSRLAG NTLLDLDIRAKYGINIVAIKRGKEVIVSPLATEVIHQEDILIVIGSVTDISRFEKRVL HTK*" /label="ktrC CDS" gene 1366593..1367258 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /label="ktrC gene" downshifts 1367242 /Source="Nicolas_upshifts" /id="D811" /incds=0 /nref=191 /ntot=256 /MaxReadThrough="3.15176" /MaxDrop="5.50828" /score="4.60161255" /energy="-8.2" /TU="U1195" /idTUdmin="U1195" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1367349..1367355 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1367370..1367389) /Source="Nicolas_upshift_promotors" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1367370..1367389 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1367382 /Source="Nicolas_upshifts" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1367384) /Source="Nicolas_upshifts" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1367413..1369146 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 8550522, 17183219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 8550522, 17183219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine deaminase" /protein_id="NP_389335.2" /db_xref="EnsemblGenomes-Gn:BSU14520" /db_xref="EnsemblGenomes-Tr:CAB13325" /db_xref="GOA:P39761" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11044" /db_xref="UniProtKB/Swiss-Prot:P39761" /translation="MNKEALVNRLNASAKRQKADIVIKNGKIMDVYNQEWIYEDIAIT DGVIVGLGEYEGENIIDAEGQMIVPGFIDGHVHIESSMVTPIEFAKAVLPHGVTTVVT DPHEIANVSGEKGIEFMLEQARHTPLNIHFMLPSSVPAASFERSGAILKAADLKPFYE EEEVLGLAEVMDYVSVQQAEKDMVQKLLDARVAGKRIDGHLAGLSTDLINIYRTAFVL NDHEVTSKEEALDRIRRGMYVMMREGSVAKNTLNVLPAVNEKNARRFFFCTDDKHVDD LLSEGSVNHQVKMAIQAGLNPFLAYQLGSLNAAECYGLDTKGAIAPGFDADLLFVSDL ENVTVTMTMVKGQTVAEDSKAVYQDHASTAAPDQALLDSVKLAAPLNKQDFHMPIDSE QQINVIQIIPNQLETRLVQVPAPVAREFEPDTELDLLKIAVVERHKGLKETGLGVVKG FGFKSGAIATTISHDSHNIIAVGTNDEDIAAAVNKLQEIGGGLTIIKNGEELHSVPLP IAGLLSDQSAEQVNQSLLTLHDKLSLIGFTGGFNPFLTLSFLALPVIPDIKMTTTGLF DVKSFQHISLQ*" /label="adeC CDS" gene 1367413..1369146 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /label="adeC gene" S_feature complement(1368541..1369145) /Source="Nicolas_S_feature" /locus_tag="new_1522479_1523083_c" /HighExp="Etha, C30, C90, dia15, LBGexp, Cold, dia5, S8, G180, S7" /AntisenseName="adeC" /AntisenseCor="-9.8927927273806792E-3" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S528" downshifts 1369135 /Source="Nicolas_upshifts" /id="D812" /incds=0 /nref=51 /ntot=223 /MaxReadThrough="1.93923" /MaxDrop="6.63088" /score="44.3452043" /energy="-19.5" /TU="NA" /idTUdmin="U1197" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1369180..1370847) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease J1" /protein_id="NP_389336.1" /db_xref="EnsemblGenomes-Gn:BSU14530" /db_xref="EnsemblGenomes-Tr:CAB13326" /db_xref="GOA:Q45493" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001587" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="PDB:3ZQ4" /db_xref="SubtiList:BG11813" /db_xref="UniProtKB/Swiss-Prot:Q45493" /translation="MKFVKNDQTAVFALGGLGEIGKNTYAVQFQDEIVLIDAGIKFPE DELLGIDYVIPDYTYLVKNEDKIKGLFITHGHEDHIGGIPYLLRQVNIPVYGGKLAIG LLRNKLEEHGLLRQTKLNIIGEDDIVKFRKTAVSFFRTTHSIPDSYGIVVKTPPGNIV HTGDFKFDFTPVGEPANLTKMAEIGKEGVLCLLSDSTNSENPEFTMSERRVGESIHDI FRKVDGRIIFATFASNIHRLQQVIEAAVQNGRKVAVFGRSMESAIEIGQTLGYINCPK NTFIEHNEINRMPANKVTILCTGSQGEPMAALSRIANGTHRQISINPGDTVVFSSSPI PGNTISVSRTINQLYRAGAEVIHGPLNDIHTSGHGGQEEQKLMLRLIKPKFFMPIHGE YRMQKMHVKLATDCGIPEENCFIMDNGEVLALKGDEASVAGKIPSGSVYIDGSGIGDI GNIVLRDRRILSEEGLVIVVVSIDMDDFKISAGPDLISRGFVYMRESGDLINDAQELI SNHLQKVMERKTTQWSEIKNEITDTLAPFLYEKTKRRPMILPIIMEV*" /label="rnjA CDS" gene complement(1369180..1370847) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /label="rnjA gene" downshifts complement(1369190) /Source="Nicolas_upshifts" /id="D813" /incds=0 /nref=149 /ntot=269 /MaxReadThrough="4.3738" /MaxDrop="8.12983" /score="37.2074215" /energy="-19.5" /TU="U1199" /idTUdmin="U1200" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1370853..1371062) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /function="9.2: DNA-dependent RNA polymerase" /experiment="publication(s) with functional evidences, PMID:18289874, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18289874, 24187087; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega 1 subunit of RNA polymerase" /protein_id="NP_389337.1" /db_xref="EnsemblGenomes-Gn:BSU14540" /db_xref="EnsemblGenomes-Tr:CAB13327" /db_xref="InterPro:IPR009907" /db_xref="SubtiList:BG13335" /db_xref="UniProtKB/Swiss-Prot:O31718" /translation="MIYKVFYQEKADEVPVREKTDSLYIEGVSERDVRTKLKEKKFNI EFITPVDGAFLEYEQQSENFKVLEL*" /label="rnpZA CDS" gene complement(1370853..1371062) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /label="rnpZA gene" promotor_-10 complement(1371099..1371118) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1371121) /Source="Nicolas_upshifts" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1371123..1371300) /Source="Nicolas_S_feature" /locus_tag="new_1525061_1525238_c" /HighExp="S5, S8, S7, S6, S4, ferm, nit, T5.0H, HiTm, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97062099999999996" /TUshortSig="SigGF" /TUshortPSig="0.828" /TUlongSig="NA" /TUlongPSig="NA" /label="S529" promotor_-35 complement(1371133..1371136) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1371301) /Source="Nicolas_upshifts" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1371303..1371314) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1371328..1371334) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1371373..1371380 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1371394..1371413 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1371410 /Source="Nicolas_upshifts" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1371448..1372221 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389338.1" /db_xref="EnsemblGenomes-Gn:BSU14550" /db_xref="EnsemblGenomes-Tr:CAB13328" /db_xref="GOA:Q45494" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11814" /db_xref="UniProtKB/Swiss-Prot:Q45494" /translation="MDSKLIFFDIDGTIYDHDKNIPESTRKTVAELQRQGHHVFIASG RSPFLVKPILEELGIHSFISYNGQFVVFENQVIYKNPLPENAIRRLLKQADEGKHPVV FMAEDTMKATVADHPHVLEGIGSLKTDYPETDDLFYEGKEIFQLLLFCQDEEEKAYAA FPEFDLVRWHELSTDVLPHGGSKAEGIKKVIERLPFDIGDTYAFGDGLNDLQMIEYVG TGVAMGNAVPELKEIADFVTKPVDEDGIAYAVKELGLLK*" /label="ykrA CDS" gene 1371448..1372221 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /label="ykrA gene" downshifts 1372192 /Source="Nicolas_upshifts" /id="D814" /incds=0 /nref=184 /ntot=249 /MaxReadThrough="2.83896" /MaxDrop="6.20802" /score="28.5519453" /energy="-15.4" /TU="U1201" /idTUdmin="U1201" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1372257..1372811) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11429456, 16207374, 23944997, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16207374, 23944997, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-cysteine deformylase (promiscuous)" /protein_id="NP_389339.1" /db_xref="EnsemblGenomes-Gn:BSU14560" /db_xref="EnsemblGenomes-Tr:CAB13329" /db_xref="GOA:Q45495" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11815" /db_xref="UniProtKB/Swiss-Prot:Q45495" /translation="MITMENIVRDGHPALRETAEPVELPPTDAEKQQLADMIEFVKNS QNPELAEKYKLRPGVGLAAPQINIKKRMIAVHAEDASGKLYSYALFNPKIVSHSVEKS YLTSGEGCLSVDEAIPGYVPRYARIRVKGTTLEGENIDIRLKGFPAIVFQHEIDHLNG VMFYDHIDKENPFKEPENAIAIER*" /label="defB CDS" gene complement(1372257..1372811) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /label="defB gene" downshifts complement(1372268) /Source="Nicolas_upshifts" /id="D815" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="1.87469" /MaxDrop="5.89844" /score="28.3817715" /energy="-15.4" /TU="NA" /idTUdmin="U1202" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1372833..1372852) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1372843) /Source="Nicolas_upshifts" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1372867..1372874) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1372896 /Source="Nicolas_upshifts" /id="D816" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="0.95601" /MaxDrop="4.18336" /score="0.455865843" /energy="-17.1" /TU="NA" /idTUdmin="U1201" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1372920) /Source="Nicolas_upshifts" /id="D817" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.11854" /MaxDrop="8.20445" /score="-8.94821426" /energy="-15.3" /TU="NA" /idTUdmin="U1204" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(1372921..1373079) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin (toxin I motif)" /protein_id="YP_003097725.1" /db_xref="EnsemblGenomes-Gn:BSU14569" /db_xref="EnsemblGenomes-Tr:CAX52616" /db_xref="GOA:C0H409" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H409" /translation="MYGYGYGGGCCSYGGYGYGGCGYGYGRTFALIVVLFILLIIVGA AYLGGGCC*" /label="ykzV CDS" gene complement(1372921..1373079) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /label="ykzV gene" CDS complement(1372986..1373129) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin" /protein_id="YP_009513955.1" /db_xref="EnsemblGenomes-Gn:BSU14568" /db_xref="EnsemblGenomes-Tr:CCQ48596" /db_xref="UniProtKB/TrEMBL:L8E9Z2" /translation="MPTYKGSGVIKRGGYVICMDMVTAEAAAVMVVTDMVAADMATAA PLR*" /label="putative antitoxin CDS" gene complement(1372986..1373129) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /label="gene" promotor_-35 1373075..1373079 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1373080..1373148) /Source="Nicolas_S_feature" /locus_tag="new_1527018_1527086_c" /HighExp="S8, S7, BT, S6, G/S, B36, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S530" promotor_-10 1373089..1373103 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1373116 /Source="Nicolas_upshifts" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1373132..1373151) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1373161) /Source="Nicolas_upshifts" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1373164..1373173) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1373235..1373242 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1373256..1373275 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1373260 /Source="Nicolas_upshifts" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1373293..1373964 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16684363, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389340.2" /db_xref="EnsemblGenomes-Gn:BSU14570" /db_xref="EnsemblGenomes-Tr:CAB13330" /db_xref="GOA:P21884" /db_xref="InterPro:IPR019454" /db_xref="InterPro:IPR036785" /db_xref="SubtiList:BG10206" /db_xref="UniProtKB/Swiss-Prot:P21884" /translation="MKDAIKRRPGIKIGAFCAMALILTGCMGQDPVDSLHHSLEKAAE SEKPFQEEQNTLKELEAKENQLYDSVMKLNMDDYKKIVALSNKALENVSKREEHLKLE NDSMKKSETEFEEAKTSAEHIKEKDIKEKADAAANHMEKRYTSYGTMYKEYKKALELN KKLYMQLKDKDLTRDDLDQQIDKVNASYEKILKYSGEFNEQTEKYNKAREDLYDAAGY RVKKS*" /label="ykyA CDS" gene 1373293..1373964 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /label="ykyA gene" promotor_-35 1373632..1373641 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1373654..1373672 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1373666 /Source="Nicolas_upshifts" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1373911 /Source="Nicolas_upshifts" /id="D818" /incds=0 /nref=96 /ntot=244 /MaxReadThrough="3.9299" /MaxDrop="6.03956" /score="20.6110953" /energy="-9.9" /TU="U1205" /idTUdmin="U1206" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 1374139..1374144 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1374161..1374180 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1374162..1374387 /Source="Nicolas_S_feature" /locus_tag="new_1528100_1528325" /HighExp="nit, MG-0.1, Diami, MG-0.2, ferm, dia5, Lbexp, dia0, Paraq, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S531" upshifts 1374162 /Source="Nicolas_upshifts" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1374166..1374185) /Source="Nicolas_upshift_promotors" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1374182) /Source="Nicolas_upshifts" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1374286..1374294) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1374292) /Source="Nicolas_upshifts" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1374308..1374316) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1374388..1375503 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /EC_number="1.2.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 alpha subunit)" /protein_id="NP_389341.1" /db_xref="EnsemblGenomes-Gn:BSU14580" /db_xref="EnsemblGenomes-Tr:CAB13331" /db_xref="GOA:P21881" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR017596" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10207" /db_xref="UniProtKB/Swiss-Prot:P21881" /translation="MAAKTKKAIVDSKKQFDAIKKQFETFQILNEKGEVVNEAAMPDL TDDQLKELMRRMVFTRVLDQRSISLNRQGRLGFYAPTAGQEASQIATHFALEKEDFVL PGYRDVPQLIWHGLPLYQAFLFSRGHFRGNQMPDDVNALSPQIIIGAQYIQTAGVALG LKKRGKKAVAITYTGDGGASQGDFYEGINFAGAYKAPAIFVVQNNRYAISTPVEKQSA AETIAQKAVAAGIVGVQVDGMDPLAVYAATAEARERAINGEGPTLIETLTFRYGPHTM AGDDPTKYRTKEIENEWEQKDPLVRFRAFLENKGLWSEEEEAKVIEDAKEEIKQAIKK ADAEPKQKVTDLMKIMYEKMPHNLEEQFEIYTQKESK*" /label="pdhA CDS" gene 1374388..1375503 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /label="pdhA gene" CDS 1375507..1376484 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /EC_number="1.2.4.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 9891797, 10735853, 11976308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 9891797, 10735853, 11976308; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 beta subunit)" /protein_id="NP_389342.1" /db_xref="EnsemblGenomes-Gn:BSU14590" /db_xref="EnsemblGenomes-Tr:CAB13332" /db_xref="GOA:P21882" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10208" /db_xref="UniProtKB/Swiss-Prot:P21882" /translation="MAQMTMIQAITDALRTELKNDENVLVFGEDVGVNGGVFRATEGL QKEFGEDRVFDTPLAESGIGGLALGLGLNGFRPVMEIQFFGFVYEVMDSVSGQMARMR YRSGGRWTSPVTIRSPFGGGVHTPELHADSLEGLVAQQPGIKVVIPSTPYDAKGLLIS AIRDNDPVVFLEHMKLYRSFRQEVPEEEYTIELGKADVKREGTDLSIITYGAMVHESL KAADELEKDGISAEVVDLRTVSPLDIDTIIASVEKTGRAIVVQEAQKQAGIAANVVAE INDRAILSLEAPVLRVAAPDTVFPFSQAESVWLPNHKDVLETARKVLEF*" /label="pdhB CDS" gene 1375507..1376484 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /label="pdhB gene" S_feature 1376485..1376598 /Source="Nicolas_S_feature" /locus_tag="new_1530423_1530536" /HighExp="G150, LBGexp, MG-0.1, G180, C30, Diami, Oxctl, G135, ferm, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S532" promotor_-10 complement(1376519..1376538) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1376536) /Source="Nicolas_upshifts" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1376553..1376556) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1376599..1377927 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /EC_number="2.3.1.12" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 subunit)" /protein_id="NP_389343.1" /db_xref="EnsemblGenomes-Gn:BSU14600" /db_xref="EnsemblGenomes-Tr:CAB13333" /db_xref="GOA:P21883" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10209" /db_xref="UniProtKB/Swiss-Prot:P21883" /translation="MAFEFKLPDIGEGIHEGEIVKWFVKPNDEVDEDDVLAEVQNDKA VVEIPSPVKGKVLELKVEEGTVATVGQTIITFDAPGYEDLQFKGSDESDDAKTEAQVQ STAEAGQDVAKEEQAQEPAKATGAGQQDQAEVDPNKRVIAMPSVRKYAREKGVDIRKV TGSGNNGRVVKEDIDSFVNGGAQEAAPQETAAPQETAAKPAAAPAPEGEFPETREKMS GIRKAIAKAMVNSKHTAPHVTLMDEVDVTNLVAHRKQFKQVAADQGIKLTYLPYVVKA LTSALKKFPVLNTSIDDKTDEVIQKHYFNIGIAADTEKGLLVPVVKNADRKSVFEISD EINGLATKAREGKLAPAEMKGASCTITNIGSAGGQWFTPVINHPEVAILGIGRIAEKA IVRDGEIVAAPVLALSLSFDHRMIDGATAQNALNHIKRLLNDPQLILMEA*" /label="pdhC CDS" gene 1376599..1377927 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /label="pdhC gene" promotor_-35 1376743..1376750 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1376765..1376784 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1376768 /Source="Nicolas_upshifts" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="upshifts" CDS 1377932..1379344 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /EC_number="1.8.1.4" /EC_number="1.2.1.25" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 6815422, 9352926, 9588797, 12682299, 21856851" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 6815422, 9352926, 9588797, 12682299, 21856851; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes" /protein_id="NP_389344.1" /db_xref="EnsemblGenomes-Gn:BSU14610" /db_xref="EnsemblGenomes-Tr:CAB13334" /db_xref="GOA:P21880" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10210" /db_xref="UniProtKB/Swiss-Prot:P21880" /translation="MVVGDFPIETDTLVIGAGPGGYVAAIRAAQLGQKVTVVEKATLG GVCLNVGCIPSKALINAGHRYENAKHSDDMGITAENVTVDFTKVQEWKASVVNKLTGG VAGLLKGNKVDVVKGEAYFVDSNSVRVMDENSAQTYTFKNAIIATGSRPIELPNFKYS ERVLNSTGALALKEIPKKLVVIGGGYIGTELGTAYANFGTELVILEGGDEILPGFEKQ MSSLVTRRLKKKGNVEIHTNAMAKGVEERPDGVTVTFEVKGEEKTVDADYVLITVGRR PNTDELGLEQVGIEMTDRGIVKTDKQCRTNVPNIYAIGDIIEGPPLAHKASYEGKIAA EAIAGEPAEIDYLGIPAVVFSEPELASVGYTEAQAKEEGLDIVAAKFPFAANGRALSL NETDGFMKLITRKEDGLVIGAQIAGASASDMISELSLAIEGGMTAEDIAMTIHAHPTL GEITMEAAEVAIGSPIHIVK*" /label="pdhD CDS" gene 1377932..1379344 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /label="pdhD gene" downshifts 1379341 /Source="Nicolas_upshifts" /id="D819" /incds=0 /nref=241 /ntot=268 /MaxReadThrough="1.82289" /MaxDrop="9.27853" /score="33.2247807" /energy="-12.1" /TU="NA" /idTUdmin="U1207" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1379389..1379763) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1936936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1936936; Product type s : structure" /codon_start=1 /transl_table=11 /product="small peptidoglycan-associated lipoprotein" /protein_id="NP_389345.1" /db_xref="EnsemblGenomes-Gn:BSU14620" /db_xref="EnsemblGenomes-Tr:CAB13335" /db_xref="GOA:P39910" /db_xref="SubtiList:BG10211" /db_xref="UniProtKB/Swiss-Prot:P39910" /translation="MRYRAVFPMLIIVFALSGCTLSTINPMKKSRIDNIHHTQILFFS DENQIDQEAPYYDALLDLEKDYPEQIDKMKVYDKKEGWEDEIETVPTLMVVDQRHVVV KIEGCVKKKEDIIKPLQHVLSK*" /label="slp CDS" gene complement(1379389..1379763) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /label="slp gene" downshifts complement(1379437) /Source="Nicolas_upshifts" /id="D820" /incds=0 /nref=26 /ntot=132 /MaxReadThrough="1.54024" /MaxDrop="3.69756" /score="4.23955997" /energy="-12.1" /TU="NA" /idTUdmin="U1212" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(1379794..1379813) /Source="Nicolas_upshift_promotors" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1379804) /Source="Nicolas_upshifts" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1379967..1379972 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-35" promotor_-10 1379988..1380006 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-10" upshifts 1379998 /Source="Nicolas_upshifts" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="upshifts" S_feature 1380002..1380111 /Source="Nicolas_S_feature" /locus_tag="new_1533940_1534049" /HighExp="S4, S5, S7, S6, S8, S3, BT, G/S, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S533" downshifts complement(1380034) /Source="Nicolas_upshifts" /id="D821" /incds=0 /nref=4 /ntot=18 /MaxReadThrough="1.96608" /MaxDrop="3.4036" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1380095..1380102 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1380113 /Source="Nicolas_upshifts" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1380117..1380136 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1380132..1380342 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /product="small regulatory RNA and messenger RNA (argininemetabolism)" /experiment="publication(s) with functional evidences, PMID:16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348; Product type n: RNA" /function="16.3: Control" /label="srrA RNA" gene 1380132..1380342 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /label="srrA gene" CDS 1380182..1380301 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16164558, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 20444087, 27449348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of GapA synthesis" /protein_id="YP_003097726.1" /db_xref="EnsemblGenomes-Gn:BSU14629" /db_xref="EnsemblGenomes-Tr:CAX52617" /db_xref="InterPro:IPR025236" /db_xref="UniProtKB/Swiss-Prot:C0H410" /translation="MGTIVCQDCNEAIHYFEDEKVTTLYGTCCGQCQCPVDEE*" /label="rgpA CDS" gene 1380182..1380301 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /label="rgpA gene" downshifts complement(1380188) /Source="Nicolas_upshifts" /id="D822" /incds=0 /nref=6 /ntot=35 /MaxReadThrough="3.43398" /MaxDrop="4.36472" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts 1380288 /Source="Nicolas_upshifts" /id="D823" /incds=0 /nref=59 /ntot=171 /MaxReadThrough="5.69396" /MaxDrop="7.24152" /score="51.2534618" /energy="-16.8" /TU="U1214" /idTUdmin="U1213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1380333..1381936 /Source="Nicolas_S_feature" /locus_tag="new_1534271_1535874" /HighExp="M9-stat, M0t90, B60, M40t90, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T0.30H" /AntisenseName="speA" /AntisenseCor="-0.33575411980382203" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.998" /label="S534" CDS complement(1380341..1381813) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /EC_number="4.1.1.19" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 19114526, 19255484, 20876533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 19114526, 19255484, 20876533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine decarboxylase" /protein_id="NP_389346.1" /db_xref="EnsemblGenomes-Gn:BSU14630" /db_xref="EnsemblGenomes-Tr:CAB13336" /db_xref="GOA:P21885" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10212" /db_xref="UniProtKB/Swiss-Prot:P21885" /translation="MSQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGE NALSIDLINIEPLDDLHAPKGIIKQAQDLAAEAFGADHTFFSVQGTSGAIMTMVMAVC GPGDKIIIPRNVHKSIMTAIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPD AKGLLVINPTYFGVAADLKSIVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGAD IAATSVHKLGGSLTQSSILNMREGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRL ATEGRQLAEETLKLANQTRDRLNQIEGIYCVGSEILGSKAAYSYDPTKLIISVKSLGL TGHDVEKWLRESFNIEVELSDLYNILCIFTPGDSQNDADRLVEALTEIAQQMSEQDVT HQQTEVLLPEIPLLAMTPRDAFYANTEVIPLKEASGRIIAEFVMVYPPGIPIFIPGEI ITEENISYIFKNLDAGLPVQGPEDSTLHMIRVIKEQKAIQ*" /label="speA CDS" gene complement(1380341..1381813) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /label="speA gene" downshifts complement(1380359) /Source="Nicolas_upshifts" /id="D824" /incds=0 /nref=62 /ntot=198 /MaxReadThrough="3.88498" /MaxDrop="6.76978" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(1381814..1381909) /Source="Nicolas_S_feature" /locus_tag="new_1535752_1535847_c" /HighExp="Paraq, G180, LBGexp, Oxctl, G150, G135, C30, H2O2, BMM, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S535" promotor_-10 complement(1381892..1381911) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1381909) /Source="Nicolas_upshifts" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1381916..1381919 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1381926..1381933) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1381934..1381953 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1381938 /Source="Nicolas_upshifts" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="upshifts" CDS 1381998..1382264 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389347.1" /db_xref="EnsemblGenomes-Gn:BSU14640" /db_xref="EnsemblGenomes-Tr:CAB13337" /db_xref="InterPro:IPR007920" /db_xref="InterPro:IPR023324" /db_xref="SubtiList:BG11816" /db_xref="UniProtKB/Swiss-Prot:Q45497" /translation="MEYQYPMNEDWTTEEAVDVIAFFQQVELAYEKGADREELLKAYR RFKEIVPGKAEEKKLCGEFEEQSTYSPYRTVKQARESDHAKIKM*" /label="yktA CDS" gene 1381998..1382264 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /label="yktA gene" downshifts 1382246 /Source="Nicolas_upshifts" /id="D825" /incds=0 /nref=105 /ntot=250 /MaxReadThrough="2.62284" /MaxDrop="5.09814" /score="40.0811023" /energy="-16.1" /TU="NA" /idTUdmin="U1214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1382297..1382935) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25643072" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389348.1" /db_xref="EnsemblGenomes-Gn:BSU14650" /db_xref="EnsemblGenomes-Tr:CAB13338" /db_xref="InterPro:IPR009403" /db_xref="PDB:2A8E" /db_xref="SubtiList:BG11817" /db_xref="UniProtKB/Swiss-Prot:Q45498" /translation="MTQMRFTEEDFNTFTIEGLDARMEVLKETVRPKLTALGEHFAPT LSALTGDEMFPHVAKHARRSVNPPADSWVAFANSKRGYKKLPHFQIGLWESHVFVWFA IIYESPIKEEYGKLLEVNQETITKNIPDSFVWSADHTKPGVHKQSEMDKEQLKTLFER LQTVKKAELLCGIQLQKEEVLNMNNQEFLQRIDDAFKQLAFLYRLTQKVTQA*" /label="yktB CDS" gene complement(1382297..1382935) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /label="yktB gene" downshifts complement(1382322) /Source="Nicolas_upshifts" /id="D826" /incds=0 /nref=184 /ntot=257 /MaxReadThrough="2.62959" /MaxDrop="6.54203" /score="26.7765804" /energy="-14.5" /TU="U1217" /idTUdmin="U1217" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1382956..1382975) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1382980) /Source="Nicolas_upshifts" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1382990..1382994) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1383005..1383011 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1383026..1383044 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1383027 /Source="Nicolas_upshifts" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1383065..1383074 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1383087..1383106 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1383091..1383174 /Source="Nicolas_S_feature" /locus_tag="new_1537029_1537112" /HighExp="Etha, S7, M9-stat, S6, S8, BT, Gly, Salt, B60, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S536" upshifts 1383091 /Source="Nicolas_upshifts" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1383175..1383363 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved general stress protein" /protein_id="NP_389349.1" /db_xref="EnsemblGenomes-Gn:BSU14660" /db_xref="EnsemblGenomes-Tr:CAB13339" /db_xref="SubtiList:BG13337" /db_xref="UniProtKB/Swiss-Prot:O31719" /translation="MRQVVKEGFKEEKNNRVAVWRLEVDYELATLYEAMQKENEEQIE QSKNKLERLRKEWIRLNG*" /label="ykzI CDS" gene 1383175..1383363 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /label="ykzI gene" downshifts complement(1383180) /Source="Nicolas_upshifts" /id="D827" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="1.50398" /MaxDrop="3.97385" /score="26.7765804" /energy="-14.5" /TU="NA" /idTUdmin="U1220" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1383356 /Source="Nicolas_upshifts" /id="D828" /incds=0 /nref=13 /ntot=45 /MaxReadThrough="7.33866" /MaxDrop="6.12123" /score="-8.73613673" /energy="-8.1" /TU="U1218,U1219" /idTUdmin="U1219" /TUdmin="-628" /isTUend="FALSE" /label="downshifts" upshifts complement(1383378) /Source="Nicolas_upshifts" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1383386..1383389) /Source="Nicolas_upshift_promotors" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1383433..1383436 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1383453..1383472 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1383456 /Source="Nicolas_upshifts" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="upshifts" CDS 1383503..1384300 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /EC_number="3.1.3.-" /EC_number="3.1.3.25" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914086, 16682444, 22333191, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914086, 16682444, 22333191, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inositol monophosphatase / 5' nucleotidase (purine nucleoside monophosphate)" /protein_id="NP_389350.1" /db_xref="EnsemblGenomes-Gn:BSU14670" /db_xref="EnsemblGenomes-Tr:CAB13340" /db_xref="GOA:Q45499" /db_xref="InterPro:IPR000760" /db_xref="InterPro:IPR020550" /db_xref="InterPro:IPR020583" /db_xref="InterPro:IPR033942" /db_xref="SubtiList:BG11818" /db_xref="UniProtKB/Swiss-Prot:Q45499" /translation="MTNWTEIDEIAKKWIREAGARITQSMHESLTIETKSNPNDLVTN IDKETEKFFIDRIQETFPGHRILGEEGQGDKIHSLEGVVWIIDPIDGTMNFVHQQRNF AISIGIFENGEGKIGLIYDVVHDELYHAFSGRGAYMNETKLAPLKETVIEEAILAINA TWVTENRRIDQSVLAPLVKRVRGTRSYGSAALELANVAAGRIDAYITMRLAPWDYAAG CVLLNEVGGTYTTIEGEPFTFLENHSVLAGNPSIHKTIFEEYLHARK*" /label="suhB CDS" gene 1383503..1384300 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /label="suhB gene" CDS 1384326..1384754 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389351.1" /db_xref="EnsemblGenomes-Gn:BSU14680" /db_xref="EnsemblGenomes-Tr:CAB13341" /db_xref="GOA:O31720" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13331" /db_xref="UniProtKB/Swiss-Prot:O31720" /translation="MLEKLAEAHPVWKEEEFGDKDAEDYIISYSMYNGSWLVWEKDGM PVAVSYHLEWSPSNGKPWLGTVLIDPAEEKKGHAKMIIEQISKLLRAKHKAMFAGVPI ERREWILFLSQCGFEQLKTEKDEKGKSFMILVKPLAEAAV*" /label="ykzC CDS" gene 1384326..1384754 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /label="ykzC gene" downshifts 1384711 /Source="Nicolas_upshifts" /id="D829" /incds=0 /nref=80 /ntot=232 /MaxReadThrough="4.50069" /MaxDrop="4.3098" /score="-9.99315734" /energy="-11.8" /TU="U1218,U1221" /idTUdmin="U1218" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" S_feature 1384755..1385708 /Source="Nicolas_S_feature" /locus_tag="new_1538693_1539646" /HighExp="H2O2, dia15, Diami, Paraq, G180, G135, G150, dia5, Heat, LBGexp" /AntisenseName="yktD" /AntisenseCor="-1.5120906229522399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="0.117724" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S537" downshifts complement(1384830) /Source="Nicolas_upshifts" /id="D830" /incds=0 /nref=4 /ntot=85 /MaxReadThrough="0.88821" /MaxDrop="3.44773" /score="19.9363134" /energy="-12.8" /TU="NA" /idTUdmin="U1222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1384832..1385746) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_389352.1" /db_xref="EnsemblGenomes-Gn:BSU14690" /db_xref="EnsemblGenomes-Tr:CAB13342" /db_xref="GOA:Q45500" /db_xref="InterPro:IPR007213" /db_xref="InterPro:IPR011610" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11819" /db_xref="UniProtKB/Swiss-Prot:Q45500" /translation="MRKNESSLTSLISAFARAYHSRYDTPLIFDDFIAKDLINEKEFI DISKNMIQEISFFNKEIAERLQNDPEKILKWVAQIQLSPTPLARASYCEKVLHNELIL GAKQYVILGAGLDTFCFRHPELENSLQVFEVDHPATQQLKKNKLKDANLTIPGHLHFV PMDFTKTFSYDPLLDEGFKNTKTFFSLLGVSYYVTREENASLISNLFSHVPPGSSIVF DYADETLFTAKGTSNRVEHMVKMAAASGEPMKSCFTYQEIEHLLESSGLLIYEHLSPD DINDLFFSNRKDNLSAFETIHYIHAVKK*" /label="yktD CDS" gene complement(1384832..1385746) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /label="yktD gene" promotor_-10 complement(1385812..1385831) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1385820) /Source="Nicolas_upshifts" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1385846..1385853) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1386098..1387663) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /EC_number="3.4.24.28" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2128597, 6090407, 8436952, 15205417, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2128597, 6090407, 8436952, 15205417, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral metalloprotease" /protein_id="NP_389353.1" /db_xref="EnsemblGenomes-Gn:BSU14700" /db_xref="EnsemblGenomes-Tr:CAB13343" /db_xref="GOA:P68736" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10448" /db_xref="UniProtKB/Swiss-Prot:P68736" /translation="MGLGKKLSVAVAASFMSLSISLPGVQAAEGHQLKENQTNFLSKN AIAQSELSAPNDKAVKQFLKKNSNIFKGDPSKRLKLVESTTDALGYKHFRYAPVVNGV PIKDSQVIVHVDKSDNVYAVNGELHNQSAAKTDNSQKVSSEKALALAFKAIGKSPDAV SNGAAKNSNKAELKAIETKDGSYRLAYDVTIRYVEPEPANWEVLVDAETGSILKQQNK VEHAAATGSGTTLKGATVPLNISYEGGKYVLRDLSKPTGTQIITYDLQNRQSRLPGTL VSSTTKTFTSSSQRAAVDAHYNLGKVYDYFYSNFKRNSYDNKGSKIVSSVHYGTQYNN AAWTGDQMIYGDGDGSFFSPLSGSLDVTAHEMTHGVTQETANLIYENQPGALNESFSD VFGYFNDTEDWDIGEDITVSQPALRSLSNPTKYNQPDNYANYRNLPNTDEGDYGGVHT NSGIPNKAAYNTITKLGVSKSQQIYYRALTTYLTPSSTFKDAKAALIQSARDLYGSTD AAKVEAAWNAVGL*" /label="nprE CDS" gene complement(1386098..1387663) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /label="nprE gene" promotor_-10 complement(1387698..1387717) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1387709) /Source="Nicolas_upshifts" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1387731..1387738) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1387948..1389888 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16501307" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389354.1" /db_xref="EnsemblGenomes-Gn:BSU14710" /db_xref="EnsemblGenomes-Tr:CAB13344" /db_xref="GOA:O07625" /db_xref="SubtiList:BG13338" /db_xref="UniProtKB/Swiss-Prot:O07625" /translation="MLFVLELFSHYVLHFERYFILSRQSTLLIQWSIVVLAGLYLLVH HPKINRQRTMFLAGVILRIVLLAGVSVELIHQVQSTNFTSAYLREDGKELLPLLHFLL YGYVLLTAFHYMLMPRDHGGKGKFYTFDLAVVSLPIVQMIFSFFSYWKEYPDGMEPIA FVFLFFIITLPIALNVVFFKLYWRTDKILLGLFYTLIIGLLVLLLAPYPNQISKDYGA VMPYTIYLAMAGFLMSYHLFQKSGKVYVRVNKWVTMAVMVFFVLLLNPIYNIGTAAFA VSKPANVHDSFNFVGEHISSEKAEQILKSFFPTDETLYLHDTNMDVHYFYSFESKGYK AEVDEVSQLIRNYEYLQKAHGKKLTNQEYKRKSIAFLERHGRVLHKDHIETKVSQEDG QTVVRIYLKNQLHKKDHADDGAVFYWEKETLMGFSEDPSIYQLDSLLHVHITEQDIHD KVEQMFTALNISKQPYQITDIESDSLLGSMVRVETKVGIVLEFEGESGCLHSLSLPMK KNISMANSRLQHQILSIFDARGSEKKKKSSQGDMVMYTDSSKTYEFVEAQGQLNVYVY SDTPDQSFPYTYRNGTLAYEKVASLYQDVIYKKRMRPIIVQRGDERHYAWLIIIQPFG SNRHDAYVVDGETQEVKSLYES*" /label="ylaA CDS" gene 1387948..1389888 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /label="ylaA gene" CDS 1389878..1390147 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 16501307" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389355.1" /db_xref="EnsemblGenomes-Gn:BSU14720" /db_xref="EnsemblGenomes-Tr:CAB13345" /db_xref="GOA:O07626" /db_xref="SubtiList:BG13339" /db_xref="UniProtKB/Swiss-Prot:O07626" /translation="MNHKEKESVFVDLYDLYKEGELEDESMEWMKQHESLFQKNAEDL KSKTCLKRSPGAEEESQIRYMKVYLSSMYICFILLAIWMTVWFYF*" /label="ylaB CDS" gene 1389878..1390147 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /label="ylaB gene" promotor_-35 1390113..1390117 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1390131..1390150 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1390144 /Source="Nicolas_upshifts" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1390147..1390668 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF-type sigma factor" /protein_id="NP_389356.1" /db_xref="EnsemblGenomes-Gn:BSU14730" /db_xref="EnsemblGenomes-Tr:CAB13346" /db_xref="GOA:O07627" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13340" /db_xref="UniProtKB/Swiss-Prot:O07627" /translation="MKHRDSIEDLYRQYYQEILNYLFRRTHHLETAKDLAQDTFVKAL NGLASFRGHSSIRTWLYTIAHHTFINWYRRDVKYQFTEISKNEGLTQTTYDQPEQYLS RTVKSETLRQELLKLKDQHQSVLILREFQELSYEEIAEILGWSLSKVNTTLHRARLEL KKNMTKSREEERI*" /label="sigP CDS" gene 1390147..1390668 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /label="sigP gene" CDS 1390665..1390958 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-SigP(YlaC) sigma factor" /protein_id="NP_389357.1" /db_xref="EnsemblGenomes-Gn:BSU14740" /db_xref="EnsemblGenomes-Tr:CAB13347" /db_xref="GOA:O07628" /db_xref="InterPro:IPR027383" /db_xref="SubtiList:BG13341" /db_xref="UniProtKB/Swiss-Prot:O07628" /translation="MTCFLVRDLLPLYLEGDCKRETEHVIEEHLKMCSSCRDMYDTMA EPFELESEQAVEEAYLPEEELRFKQRYYGLLIMKAACWFGAAVAMMLIIKLLI*" /label="sigQ CDS" gene 1390665..1390958 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /label="sigQ gene" CDS complement(1390998..1391609) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389358.1" /db_xref="EnsemblGenomes-Gn:BSU14750" /db_xref="EnsemblGenomes-Tr:CAB13348" /db_xref="SubtiList:BG13342" /db_xref="UniProtKB/Swiss-Prot:O07629" /translation="MKKTFVKKAMLTTAAMTSAALLTFGPDAASAKTPVDNTAVQLQH QASTNEDLNTFIDILNQCIYEQDGVYYFDSEKAVELGMTKEEAQVIATLWESTSEFFS IVSQCVYLEDGNYKFDTEKAVELGFTEKEALALEQFFSAVSLKIHILQAAIVLQDDVY SYDKDAALQAGATPLQADVYEKLFSALSQEQLAAIYDMIHPQA*" /label="ylaE CDS" gene complement(1390998..1391609) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /label="ylaE gene" downshifts complement(1391012) /Source="Nicolas_upshifts" /id="D831" /incds=0 /nref=44 /ntot=184 /MaxReadThrough="1.37453" /MaxDrop="4.23106" /score="20.8244305" /energy="-11.7" /TU="NA" /idTUdmin="U1225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1391641..1391660) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1391650) /Source="Nicolas_upshifts" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1391675..1391678) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1391865) /Source="Nicolas_upshifts" /id="D832" /incds=0 /nref=18 /ntot=138 /MaxReadThrough="2.72081" /MaxDrop="5.25382" /score="5.78870736" /energy="-8.3" /TU="NA" /idTUdmin="U1226" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1391882..1392070) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389359.1" /db_xref="EnsemblGenomes-Gn:BSU14760" /db_xref="EnsemblGenomes-Tr:CAB13349" /db_xref="GOA:O07630" /db_xref="InterPro:IPR035211" /db_xref="SubtiList:BG13343" /db_xref="UniProtKB/Swiss-Prot:O07630" /translation="MKKMNWLLLLFAFAAVFSIMLIGVFIAEKSPAGIIASIVLVCAV MGGGFTLKKKMREQGLLD*" /label="ylaF CDS" gene complement(1391882..1392070) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /label="ylaF gene" downshifts complement(1391936) /Source="Nicolas_upshifts" /id="D833" /incds=0 /nref=9 /ntot=204 /MaxReadThrough="4.38484" /MaxDrop="3.2214" /score="5.78870736" /energy="-8.3" /TU="U1226" /idTUdmin="U1226" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1392092..1392111) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1392109) /Source="Nicolas_upshifts" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1392124..1392131) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1392137..1392156 /Source="Nicolas_upshift_promotors" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1392144 /Source="Nicolas_upshifts" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="upshifts" CDS 1392183..1394021 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11683274, 12399512, 9642082, 25135187, 26283392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-associated GTPase" /protein_id="NP_389360.1" /db_xref="EnsemblGenomes-Gn:BSU14770" /db_xref="EnsemblGenomes-Tr:CAB13350" /db_xref="GOA:O07631" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006298" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035651" /db_xref="SubtiList:BG13344" /db_xref="UniProtKB/Swiss-Prot:O07631" /translation="MKLRNDLRNIAIIAHVDHGKTTLVDQLLHQAGTFRANEQVAERA MDSNDLERERGITILAKNTAINYKDTRINILDTPGHADFGGEVERIMKMVDGVVLVVD AYEGCMPQTRFVLKKALEQNLNPVVVVNKIDRDFARPEEVIDEVLDLFIELDANEEQL EFPVVYASAINGTASLDPKQQDENMEALYETIIKHVPAPVDNAEEPLQFQVALLDYND YVGRIGIGRVFRGTMKVGQQVSLMKLDGTAKSFRVTKIFGFQGLKRVEIEEAKAGDLV AVSGMEDINVGETVCPVDHQDPLPVLRIDEPTLQMTFVVNNSPFAGREGKYVTARKIE ERLQSQLQTDVSLRVEPTASPDAWVVSGRGELHLSILIENMRREGYELQVSKPEVIIK EIDGVRCEPVERVQIDVPEEHTGSVMESMGARKGEMVDMINNGNGQVRLIFTVPSRGL IGYSTEFLSLTRGFGILNHTFDSYQPMQAGQVGGRRQGVLVSMENGKATSYGIQGIED RGVIFVEPGTEVYEGMIVGEHNRDNDLVVNVSKMKQQTNVRSATKDQTTTIKKARIMS LEESLEYLNEDEYCEVTPESIRLRKKILNKNEREKAAKKKKTAGLS*" /label="bipA CDS" gene 1392183..1394021 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /label="bipA gene" CDS 1394078..1394395 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unkown function" /protein_id="NP_389361.1" /db_xref="EnsemblGenomes-Gn:BSU14780" /db_xref="EnsemblGenomes-Tr:CAB13351" /db_xref="GOA:O07632" /db_xref="InterPro:IPR025620" /db_xref="SubtiList:BG13345" /db_xref="UniProtKB/Swiss-Prot:O07632" /translation="MNDVSERLSFFAALYQVDRQPAAGMWLLYGTIFVLAVIVFKLGF AKRLPVLKSAVVYVFLALGCTVLTFLGVFLPVAEGLVVAALILIIYKIRLYQSKKGQS AKS*" /label="ylaH CDS" gene 1394078..1394395 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /label="ylaH gene" downshifts 1394369 /Source="Nicolas_upshifts" /id="D834" /incds=0 /nref=241 /ntot=297 /MaxReadThrough="2.76511" /MaxDrop="7.50514" /score="29.8701447" /energy="-12.5" /TU="NA" /idTUdmin="U1227" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(1394444) /Source="Nicolas_upshifts" /id="D835" /incds=0 /nref=240 /ntot=265 /MaxReadThrough="0.672690000000001" /MaxDrop="7.03405" /score="10.4340016" /energy="-12.5" /TU="NA" /idTUdmin="U1228" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1394451..1394660) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389362.1" /db_xref="EnsemblGenomes-Gn:BSU14790" /db_xref="EnsemblGenomes-Tr:CAB13352" /db_xref="InterPro:IPR019241" /db_xref="SubtiList:BG13346" /db_xref="UniProtKB/Swiss-Prot:O07633" /translation="MMRVKCSICDKIETIDDDTLIAKRLRNRPIHTYMCQECHDRIAK KTEERLKTGKFTFHPGQQKKEKVKK*" /label="ylaI CDS" gene complement(1394451..1394660) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /label="ylaI gene" misc_feature complement(1394674..1394693) /Source="Nicolas_upshift_promotors" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1394689) /Source="Nicolas_upshifts" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1394743..1395372) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_389363.1" /db_xref="EnsemblGenomes-Gn:BSU14800" /db_xref="EnsemblGenomes-Tr:CAB13353" /db_xref="GOA:O07634" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13347" /db_xref="UniProtKB/Swiss-Prot:O07634" /translation="MRILFIIIQLTLILSACAYQQGKQGQNVEKESTRQQETKPIHVK DTTQETKDNGTRTDIAKHLVSVAEKNPDVKDATAVVLGGYAVVGIDVDDTLDRSKVET IKYSVAQALKNDRYGANAVVIADPDTVSRLREMSREISEGHPVTGILDELAAIVGRVL PEVPNDVIDNEDEPQTKQQNDQLNRKQQQEMEKEQNDQSDHHMKKNNND*" /label="ylaJ CDS" gene complement(1394743..1395372) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /label="ylaJ gene" downshifts complement(1394774) /Source="Nicolas_upshifts" /id="D836" /incds=0 /nref=57 /ntot=112 /MaxReadThrough="1.90936" /MaxDrop="5.8475" /score="3.85709048" /energy="-7.2" /TU="NA" /idTUdmin="U1229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1395274..1395292) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1395280) /Source="Nicolas_upshifts" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1395304..1395312) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1395407..1395418) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1395412) /Source="Nicolas_upshifts" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1395424..1395429 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-35" promotor_-35 complement(1395433..1395439) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1395445..1395463 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-10" upshifts 1395445 /Source="Nicolas_upshifts" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="upshifts" S_feature 1395446..1395526 /Source="Nicolas_S_feature" /locus_tag="new_1549384_1549464" /HighExp="S3, S5, S4, S8, S6, S7, LoTm, T5.0H, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S538" CDS 1395527..1396855 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12762842, 17114254; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phosphate starvation inducible protein" /protein_id="NP_389364.1" /db_xref="EnsemblGenomes-Gn:BSU14810" /db_xref="EnsemblGenomes-Tr:CAB13354" /db_xref="GOA:O07635" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG13348" /db_xref="UniProtKB/Swiss-Prot:O07635" /translation="MSKIYVLDTNVLLQDPNAIFSFEENEVVIPAVVLEEVDSKKRYM DEVGRNARHVSKLIDALRQKGRLHEHVPLDTGGTLRIELNHRSFHQLQEIFIEKTNDN RILAVAKNLSLEEETKENGRPVILVSKDVLVRVKADAIGLLAEDFLNDRVVDNDEMYS GYKDLYISQQLFSSFYGKNQISVNDVKQHAFYPNQFALMKDELGGSSSAVGIADKTGT VLKRLVFDDEHIWGIRPKNVQQTMALELLLREDIPLVTLIGKAGTGKTLLALAAGLLQ TEDLGIYKKLVVARPIVPVGKDIGYLPGEKEEKLKPWMQPIFDNLEFLFNAKKPGELD AILAGIGSIQVEALTYIRGRSIPDQFIIIDEAQNLTRHEVKTLLTRVGEGSKIVLMGD PEQIDHPYLDSLNNGLAYVVERFKGQPISGSVKLLKGERSGLAQLAADLL*" /label="ylaK CDS" gene 1395527..1396855 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /label="ylaK gene" S_feature complement(1396711..1396858) /Source="Nicolas_S_feature" /locus_tag="new_1550649_1550796_c" /HighExp="M40t90, M0t90, dia15, Lbtran, dia5, Etha, Mt0, Gly, LBGtran, LPhT" /AntisenseName="ylaK" /AntisenseCor="-0.66426410013570203" /AntisenseRegPval="-34.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S539" downshifts complement(1396754) /Source="Nicolas_upshifts" /id="D837" /incds=1 /nref=6 /ntot=67 /MaxReadThrough="3.81309" /MaxDrop="3.44499" /score="3.85709048" /energy="-7.2" /TU="U1232" /idTUdmin="U1232" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 1396856..1397446 /Source="Nicolas_S_feature" /locus_tag="new_1550794_1551384" /HighExp="S3, S4, S6, S5, S8, S7, BT, B36, LoTm, T5.0H" /AntisenseName="ylaL" /AntisenseCor="-0.79954210237955903" /AntisenseRegPval="-60.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S540" CDS complement(1396859..1397344) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389365.1" /db_xref="EnsemblGenomes-Gn:BSU14820" /db_xref="EnsemblGenomes-Tr:CAB13355" /db_xref="GOA:O07636" /db_xref="InterPro:IPR020229" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13349" /db_xref="UniProtKB/Swiss-Prot:O07636" /translation="MSVIQVKGNVTYPITIDPSVWIFDDRKFSFDRKGDSQDTYLQSA GDESDLDPERVIREGRIAPPTLKTEKQYEKQKLMNGSFAMRLGTVLKNAEPNSSATQC VFVTSSGKAAVSLETALNSIVHFSEAGKPIQEGGPVHIYFEDPVHHKQPITDVKEIEI I*" /label="ylaL CDS" gene complement(1396859..1397344) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /label="ylaL gene" promotor_-10 complement(1397356..1397375) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1397384) /Source="Nicolas_upshifts" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1397390..1397397) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1397447..1398376 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:18459799" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18459799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine amidohydrolase; glutaminase" /protein_id="NP_389366.1" /db_xref="EnsemblGenomes-Gn:BSU14830" /db_xref="EnsemblGenomes-Tr:CAB13356" /db_xref="GOA:O07637" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="SubtiList:BG13350" /db_xref="UniProtKB/Swiss-Prot:O07637" /translation="MVCQHNDELEALVKKAKKVTDKGEVASYIPALAKADKHDLSVAI YYSNNVCLSAGDVEKTFTLQSISKVLSLALVLMEYGKDKVFSYVGQEPTGDPFNSIIK LETVNPSKPLNPMINAGALVVTSLIRGRTVKERLDYLLSFIRRLTNNQEITYCREVAE SEYSTSMINRAMCYYMKQYGIFEDDVEAVMDLYTKQCAIEMNSLDLAKIGSVFALNGR HPETGEQVISKDVARICKTFMVTCGMYNASGEFAIKVGIPAKSGVSGGIMGISPYDFG IGIFGPALDEKGNSIAGVKLLEIMSEMYRLSIF*" /label="glsB CDS" gene 1397447..1398376 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /label="glsB gene" misc_feature 1397961..1397980 /Source="Nicolas_upshift_promotors" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1397970 /Source="Nicolas_upshifts" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="upshifts" promotor_-35 1398400..1398403 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1398418..1398437 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1398426 /Source="Nicolas_upshifts" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1398474..1398755 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12682299, 16880555, 17005971,17469204" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389367.1" /db_xref="EnsemblGenomes-Gn:BSU14840" /db_xref="EnsemblGenomes-Tr:CAB13357" /db_xref="InterPro:IPR009983" /db_xref="InterPro:IPR036270" /db_xref="SubtiList:BG13351" /db_xref="UniProtKB/Swiss-Prot:O07638" /translation="MASEMIVDHRQKAFELLKVDAEKILKLIRVQMDNLTMPQCPLYE EVLDTQMFGLSREIDFAVRLGLVDEKDGKDLLYTLERELSALHDAFTAK*" /label="ylaN CDS" gene 1398474..1398755 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /label="ylaN gene" downshifts 1398744 /Source="Nicolas_upshifts" /id="D838" /incds=0 /nref=72 /ntot=227 /MaxReadThrough="5.3857" /MaxDrop="6.58793" /score="2.26145837" /energy="-6.9" /TU="U1234" /idTUdmin="U1231" /TUdmin=328 /isTUend="FALSE" /label="downshifts" promotor_-35 1398818..1398821 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1398834..1398960 /Source="Nicolas_S_feature" /locus_tag="new_1552772_1552898" /HighExp="S1, T5.0H, T4.0H, HiOs, T3.30H, T3.0H, Etha, Heat, T2.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="0.619, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S541" upshifts 1398834 /Source="Nicolas_upshifts" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1398839..1398845 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1398961..1400172 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9622350, 12626683, 15849754, 16850406, 21386816, 27895631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 12626683, 15849754, 16850406, 21386816, 27895631; Product type t : transporter" /codon_start=1 /transl_table=11 /product="cell-division protein; transporter of lipid-linked cell wall precursors" /protein_id="NP_389368.1" /db_xref="EnsemblGenomes-Gn:BSU14850" /db_xref="EnsemblGenomes-Tr:CAB13358" /db_xref="GOA:O07639" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG13352" /db_xref="UniProtKB/Swiss-Prot:O07639" /translation="MLKKMLKSYDYSLIFAIVLLCGFGLVMVYSSSMITAVSRYGVSS NFFFMRQLFALIAGGALFILMALFPYKALAHQKFQKGILLVSVLALISLFVFGHVAGN AQSWFKIGGMSIQPGEFVKLVVILYLAAVYAKKQSYIDHLLTGVAPPVVMTLIICGLI AMQPDFGTAMIIGLIATCMILCSGFSGKTLVRLVILGGIVFILVSPIIYLNQDKILTE GRLARFESLEDPFKYANSSGLQVINSYYAISSGGIFGLGLGESIQKYGYLPESHTDFI MAVIAEELGIFGVLFVIFLLGFVVIKGFYIARKCEDPFGSLLAIGISSMIAIQSFINL GGVSGLIPITGVTLPFISYGGSSLVLLLGSMGILANISMFVKYSENKKKKEPLAPKGM KKKQLKKTVYL*" /label="ftsW CDS" gene 1398961..1400172 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /label="ftsW gene" promotor_-35 1400182..1400186 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1400201..1400220 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1400220 /Source="Nicolas_upshifts" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1400247..1403693 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /EC_number="6.4.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6425269, 15134465, 20081037, 20097852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate carboxylase" /protein_id="NP_389369.1" /db_xref="EnsemblGenomes-Gn:BSU14860" /db_xref="EnsemblGenomes-Tr:CAB13359" /db_xref="GOA:Q9KWU4" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR003379" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR005930" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG12660" /db_xref="UniProtKB/Swiss-Prot:Q9KWU4" /translation="MSQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSY HRYKADEAYLVGEGKKPIDAYLDIEGIIDIAKRNKVDAIHPGYGFLSENIHFARRCEE EGIVFIGPKSEHLDMFGDKVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPI IIKASLGGGGRGMRIVRSESEVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQV IGDKQGNVVHLFERDCSVQRRHQKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINA GTVEFLVANNEFYFIEVNPRVQVEHTITEMITGVDIVQTQILVAQGHSLHSKKVNIPE QKDIFTIGYAIQSRVTTEDPQNDFMPDTGKIMAYRSGGGFGVRLDTGNSFQGAVITPY YDSLLVKLSTWALTFEQAAAKMVRNLQEFRIRGIKTNIPFLENVAKHEKFLTGQYDTS FIDTTPELFNFPKQKDRGTKMLTYIGNVTVNGFPGIGKKEKPAFDKPLGVKVDVDQQP ARGTKQILDEKGAEGLANWVKEQKSVLLTDTTFRDAHQSLLATRIRSHDLKKIANPTA ALWPELFSMEMWGGATFDVAYRFLKEDPWKRLEDLRKEVPNTLFQMLLRSSNAVGYTN YPDNVIKEFVKQSAQSGIDVFRIFDSLNWVKGMTLAIDAVRDTGKVAEAAICYTGDIL DKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKPQAAYELVSALKETIDIPVHL HTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSASGFYHAMEGNDRRPEMNV QGVELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYSNLQQQAKGVGLGDRWN EVKEMYRRVNDMFGDIVKVTPSSKVVGDMALYMVQNNLTEKDVYEKGESLDFPDSVVE LFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQEFKEQHNLEISD QDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEIERGKTLIVKL ISIGEPQPDATRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHIAASMPGTV IKVLAEAGTKVNKGDHLMINEAMKMETTVQAPFSGTIKQVHVKNGEPIQTGDLLLEIE KA*" /label="pycA CDS" gene 1400247..1403693 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /label="pycA gene" promotor_-10 complement(1403259..1403277) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1403279) /Source="Nicolas_upshifts" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1403293..1403298) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1403673 /Source="Nicolas_upshifts" /id="D839" /incds=0 /nref=20 /ntot=213 /MaxReadThrough="5.5667" /MaxDrop="6.03063" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts 1403718 /Source="Nicolas_upshifts" /id="D840" /incds=0 /nref=2 /ntot=51 /MaxReadThrough="4.21552" /MaxDrop="4.9051" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=44 /isTUend="FALSE" /label="downshifts" downshifts complement(1403750) /Source="Nicolas_upshifts" /id="D841" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="2.24992" /MaxDrop="3.11732" /score="10.1921506" /energy="-11.8" /TU="NA" /idTUdmin="U1238" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 1403762 /Source="Nicolas_upshifts" /id="D842" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="3.6246" /MaxDrop="4.10361" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(1404096..1405016) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /EC_number="1.3.-.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12206660, 15491161, 15849754, 16321940, 16850406, 26592143" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12206660, 15491161, 15849754, 16321940, 16850406, 26592143; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heme-A synthase" /protein_id="NP_389370.1" /db_xref="EnsemblGenomes-Gn:BSU14870" /db_xref="EnsemblGenomes-Tr:CAB13360" /db_xref="GOA:P12946" /db_xref="InterPro:IPR003780" /db_xref="InterPro:IPR023755" /db_xref="SubtiList:BG10213" /db_xref="UniProtKB/Swiss-Prot:P12946" /translation="MNKALKALGVLTTFVMLIVLIGGALVTKTGSGQGCGRQWPLCHG RFFPELNPASIIEWSHRFASGISIILVLSLAFWSWRKITPIFRETTFLAIMSIIFLFL QALLGALAVVFGSNALIMALHFGISLISFASVLILTLLIFEADKSVRTLVKPLQIGKK MQFHMIGILIYSYIVVYTGAYVRHTESSLACPNVPLCSPLNNGLPTQFHEWVQMGHRA AALLLFVWIIVAAVHAITSYKDQKQIFWGWISCLIFITLQALSGIMIVYSELALGFAL AHSFFIACLFGVLCYFLLLIARFRYESRQS*" /label="ctaA CDS" gene complement(1404096..1405016) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /label="ctaA gene" downshifts complement(1404102) /Source="Nicolas_upshifts" /id="D843" /incds=0 /nref=126 /ntot=238 /MaxReadThrough="2.72676" /MaxDrop="5.67271" /score="28.8671863" /energy="-15.3" /TU="U1238" /idTUdmin="U1238" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1405056..1405075) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1405071) /Source="Nicolas_upshifts" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1405089..1405096) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1405151..1405158 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1405172..1405191 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1405173..1405278 /Source="Nicolas_S_feature" /locus_tag="new_1559111_1559216" /HighExp="LBGstat, M0t90, Lbstat, BC, T0.30H, T1.30H, B60, M9-stat, M40t90, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S542" upshifts 1405173 /Source="Nicolas_upshifts" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" S_feature 1405280..1405370 /Source="Nicolas_S_feature" /locus_tag="new_1559218_1559308" /HighExp="LBGstat, M0t90, LPhT, BC, UNK1, BI, Lbexp, LBGtran, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S543" upshifts 1405280 /Source="Nicolas_upshifts" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1405286..1405289 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1405304..1405320 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1405371..1406288 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protoheme IX farnesyltransferase 2" /protein_id="NP_389371.1" /db_xref="EnsemblGenomes-Gn:BSU14880" /db_xref="EnsemblGenomes-Tr:CAB13361" /db_xref="GOA:P24009" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG10214" /db_xref="UniProtKB/Swiss-Prot:P24009" /translation="MANSRILNDTAIDGQIEETTAWKDFLSLIKIGIVNSNLITTFTG MWLALHISGLSFLGNINTVLLTLIGSSLIIAGSCAINNWYDRDIDHLMERTKVRPTVT GKIQPSQALWSGILLVALGLIMLLMTTVMAAVIGFIGVFTYVVLYTMWTKRRYTINTV VGSVSGAVPPLIGWTAVEGNIGVVAWVLFMILFIWQIPHFLALAIKKTEDYRAANIPM LPVVYGFEVTKRQIIVWVACLMPLPFFLGSLGLPIVILGLLLNIGWLILGLMGFRSKN IMKWATQMFVYSLNYMTIYFVAMVVLTLF*" /label="ctaB CDS" gene 1405371..1406288 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /label="ctaB gene" downshifts 1406317 /Source="Nicolas_upshifts" /id="D844" /incds=0 /nref=33 /ntot=75 /MaxReadThrough="8.35391" /MaxDrop="5.6457" /score="0.893081758" /energy="-11.8" /TU="U1239,U1240" /idTUdmin="U1236" /TUdmin=1719 /isTUend="FALSE" /label="downshifts" upshifts 1406336 /Source="Nicolas_upshifts" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1406337..1406342 /Source="Nicolas_upshift_promotors" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1406396..1406401 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1406416..1406434 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1406424..1406527 /Source="Nicolas_S_feature" /locus_tag="new_1560362_1560465" /HighExp="Lbstat, M0t90, M40t90, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, Sig-, SigA, SigA" /TUshortPSig="0.451, 0.407, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S544" upshifts 1406424 /Source="Nicolas_upshifts" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" CDS 1406528..1407598 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 9829923, 9882689, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 9829923, 9882689, 27503613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit II)" /protein_id="NP_389372.1" /db_xref="EnsemblGenomes-Gn:BSU14890" /db_xref="EnsemblGenomes-Tr:CAB13362" /db_xref="GOA:P24011" /db_xref="InterPro:IPR001505" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR014222" /db_xref="InterPro:IPR034236" /db_xref="InterPro:IPR036257" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10215" /db_xref="UniProtKB/Swiss-Prot:P24011" /translation="MVKHWRLILLLALVPLLLSGCGKPFLSTLKPAGEVADKQYDLTV LSTLIMVVVVAVVSVIFFYVIVRFRRSRVGENTIPKQVEGNKFLEITWTVIPILLLII LVIPVVLYTLELADTSPMDKKGRKAEDALVVNVRANLYWWEFEYPDYGIITSQELIVP TDQRVYFNLKASDVKHSFWIPSVGGKLDTNTDNENKFFLTFDSKRSKEAGDMFFGKCA ELCGPSHALMDFKVKTMSAKEFQGWTKEMKNYKSTAESDLAKQGEELFKEKNCLSCHA VEPNDKRAEAARTAPNLATFGERTKVAGVKEANKENVKAWLKDPDSIKPGNKMTGTYP KLSDSETNALYEYLKGLKAESK*" /label="ctaC CDS" gene 1406528..1407598 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /label="ctaC gene" CDS 1407631..1409499 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit I)" /protein_id="NP_389373.2" /db_xref="EnsemblGenomes-Gn:BSU14900" /db_xref="EnsemblGenomes-Tr:CAB13363" /db_xref="GOA:P24010" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014241" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10216" /db_xref="UniProtKB/Swiss-Prot:P24010" /translation="MLNALTEKRTRGSMLWDYLTTVDHKKIAILYLVAGGFFFLVGGI EAMFIRIQLAKPENAFLSAQAYNEVMTMHGTTMIFLAAMPLLFALMNAVVPLQIGARD VSFPFLNALGFWLFFFGGIFLNLSWFLGGAPDAGWTSYASLSLHSKGHGIDFFVLGLQ ISGLGTLIAGINFLATIINMRAPGMTYMRLPLFTWTTFVASALILFAFPPLTVGLALM MLDRLFGTNFFNPELGGNTVIWEHLFWIFGHPEVYILILPAFGIFSEVIPVFARKRLF GYSSMVFAIVLIGFLGFMVWVHHMFTTGLGPIANAIFAVATMAIAIPTGIKIFNWLLT IWGGNVKYTTAMLYAVSFIPSFVLGGVTGVMLAAAAADYQFHDTYFVVAHFHYVIIGG VVFGLLAGVHFWWPKMFGKILHETMGKISFVLFFIGFHLTFFIQHFVGLMGMPRRVYT FLPGQGLETGNLISTIGAFFMAAAVILLLVNVIWTSVKGEYVGADPWHDGRTLEWTVS SPPPEYNFKQLPFVRGLDPLWIEKQAGHKSMTPAEPVDDIHMPNGSILPLIISFGLFV AAFGLLYRSDYAWGLPVIFIGLGITFITMLLRSVIDDHGYHIHKEELPNDDKGVKA*" /label="ctaD CDS" gene 1407631..1409499 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /label="ctaD gene" CDS 1409499..1410122 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit III)" /protein_id="NP_389374.1" /db_xref="EnsemblGenomes-Gn:BSU14910" /db_xref="EnsemblGenomes-Tr:CAB13364" /db_xref="GOA:P24012" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10217" /db_xref="UniProtKB/Swiss-Prot:P24012" /translation="MQVQEKFTAETFPASPEKVTLEGKNKFLGFWLFLGGETVLFASL FATFLALRNSNAGDPPTTEMFDVTLVFIATMLLLTSSLTSVYAMYHMKNFSFGKMQLW LGITILLGAGFLGLEIYEFKHYTHEFGFTITSSALGSAFYTLVGTHGAHVAFGLMWIS TLMIRNAKRGLNLYTAPKFYVASLYWHFIDVVWVFIFTVVYLMGMVG*" /label="ctaE CDS" gene 1409499..1410122 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /label="ctaE gene" CDS 1410125..1410457 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit IV)" /protein_id="NP_389375.1" /db_xref="EnsemblGenomes-Gn:BSU14920" /db_xref="EnsemblGenomes-Tr:CAB13365" /db_xref="GOA:P24013" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014257" /db_xref="SubtiList:BG10218" /db_xref="UniProtKB/Swiss-Prot:P24013" /translation="MVDKKSRGHINSDLEFKKKKHAREMKYQVLSFGLMIGLTIVAFL TVATDGVGSWFTIPFIILLAAIQVIFQLYYFMHMNQKGHEAPALFLYSGVFVAFITVL AFVTIIWW*" /label="ctaF CDS" gene 1410125..1410457 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /label="ctaF gene" CDS 1410484..1411377 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /function="16.10: Respire" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14766920, 15849754, 16305244, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14766920, 15849754, 16305244, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome aa(3) assembly factor" /protein_id="NP_389376.1" /db_xref="EnsemblGenomes-Gn:BSU14930" /db_xref="EnsemblGenomes-Tr:CAB13366" /db_xref="GOA:O34329" /db_xref="InterPro:IPR014108" /db_xref="InterPro:IPR019108" /db_xref="SubtiList:BG12579" /db_xref="UniProtKB/Swiss-Prot:O34329" /translation="MNQLEIFGFRAMWSPYLFCILLGITALYLYFYRRMSSKPNRITG KEMVCFLSAMLFLYAAEGSPVDLLGHIMFSAHMVQMAVLYLVVPPLLIAGIPAWLWEK IIFRPSIKPVFSFFTTPLIALLLFNGIFSLYHVPLIFDTVKTDPFYHTLITWLIFVLA FFMWWPLVHKVERLRQLSGLMKLGYIMADGMLLTPACALIMFSGAPLYATYTDPALWA EAMRLCVPADMMGQVPLTGPEMLNTLPLLEDQQLGAVMMKIIQEIVYGTFLAVIFFQW VKKEREKDGQEEPPYIQQTIS*" /label="ctaG CDS" gene 1410484..1411377 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /label="ctaG gene" downshifts 1411352 /Source="Nicolas_upshifts" /id="D845" /incds=0 /nref=121 /ntot=229 /MaxReadThrough="1.94099" /MaxDrop="5.91271" /score="4.35633365" /energy="-13.3" /TU="NA" /idTUdmin="U1239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1411409..1411771) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389377.1" /db_xref="EnsemblGenomes-Gn:BSU14940" /db_xref="EnsemblGenomes-Tr:CAB13367" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG13353" /db_xref="UniProtKB/Swiss-Prot:O34743" /translation="MLKFTESGLEGVKAELSWLDDLMESKGLIRAGQWDYERVTYDKK FSTIEGTFYLRIQGIAAEGDVGSGRAVIQLMSPLLGKHYYPHGVEYGETEEFPVQVVT KSKALIQDIANMLKTVQM*" /label="ylbA CDS" gene complement(1411409..1411771) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /label="ylbA gene" downshifts complement(1411428) /Source="Nicolas_upshifts" /id="D846" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="1.00586" /MaxDrop="6.68145" /score="-3.42191479" /energy="-11.2" /TU="NA" /idTUdmin="U1244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1411764..1411768 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1411777..1411790 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1411795..1411814) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1411799..1411910 /Source="Nicolas_S_feature" /locus_tag="new_1565737_1565848" /HighExp="S7, S8, S4, S3, S6, S5, T5.0H, T4.0H, BC, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.368" /TUlongSig="NA" /TUlongPSig="NA" /label="S545" upshifts 1411799 /Source="Nicolas_upshifts" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1411807) /Source="Nicolas_upshifts" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1411829..1411836) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1411911..1412357 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389378.2" /db_xref="EnsemblGenomes-Gn:BSU14950" /db_xref="EnsemblGenomes-Tr:CAB13368" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG13354" /db_xref="UniProtKB/Swiss-Prot:O34682" /translation="MTKIKDLMTADLQYCTVLDNVYEAAVKMKDANVGAIPVVDEDGE TLVGIVTDRDLVLRGIAIKKPNSQKITDAMTEKPVSVEEDASVDEVLHLMASHQLRRI PVTKNKKLTGIVTLGDLSLSEQTNERAGSALSDISEGDNREEGFFH*" /label="ylbB CDS" gene 1411911..1412357 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /label="ylbB gene" promotor_-35 1411943..1411950 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1411962..1411981 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1411967 /Source="Nicolas_upshifts" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1412366..1412373 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1412387..1412406 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1412398 /Source="Nicolas_upshifts" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" CDS 1412441..1413481 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389379.1" /db_xref="EnsemblGenomes-Gn:BSU14960" /db_xref="EnsemblGenomes-Tr:CAB13369" /db_xref="GOA:O34586" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR029410" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13355" /db_xref="UniProtKB/Swiss-Prot:O34586" /translation="MKNILRAMVILLIICGTYVLFIQYGSVPEKKSNDSEPQVSNEEA QSGKRIHMPTSGLLSFMGKHADEVTKKLGEPERIDPSAYDYDWWVYNQGKDQYIQIGV LNNKVVTLFASGNDINAKPFKIGESTGEVFKTTQVAPFVNVEYKGNSYRFEFSEEDIN TRPTVKVGKMYVQLYMDKFEGKLSSIRAFDAQTFVKQRPYEVVYRGELIKPKAVSDEK WKKIQTTSEKQILDLTNVIRVKHGLAKLEWDQPTAEVAFGHSEDMKENNYFSHVSKKY GSLKDRLEEGHVDFQQAGENIAYNYVDGPAAVEGWLNSEGHRKALLNSDYTHLGVGVD RKYYTQNFIKRW*" /label="ylbC CDS" gene 1412441..1413481 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /label="ylbC gene" promotor_-10 complement(1413404..1413422) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1413409) /Source="Nicolas_upshifts" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1413438..1413443) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1413461 /Source="Nicolas_upshifts" /id="D847" /incds=0 /nref=84 /ntot=252 /MaxReadThrough="1.59604" /MaxDrop="4.17709" /score="-1.16631837" /energy="-8.1" /TU="NA" /idTUdmin="U1243" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 1413645..1413654 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1413668..1413687 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1413682 /Source="Nicolas_upshifts" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="upshifts" CDS 1413713..1414111 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19775244, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related protein (coat)" /protein_id="NP_389380.1" /db_xref="EnsemblGenomes-Gn:BSU14970" /db_xref="EnsemblGenomes-Tr:CAB13370" /db_xref="InterPro:IPR025953" /db_xref="SubtiList:BG13356" /db_xref="UniProtKB/Swiss-Prot:O34880" /translation="MANQHANHSINDFKQFVKKHPKLIKEVRKEQRSWQDVYENWVLF GESDPIWDPYREPEEASEAVPETPQKNDFVSKMVTAVKKMDVNQMNEQINKMSQSISS LQSLLNTFSGSGQKHSQPGSGQHPFSFRKD*" /label="ylbD CDS" gene 1413713..1414111 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /label="ylbD gene" downshifts complement(1413717) /Source="Nicolas_upshifts" /id="D848" /incds=0 /nref=2 /ntot=11 /MaxReadThrough="2.37349" /MaxDrop="4.0378" /score="40.2648817" /energy="-14.3" /TU="NA" /idTUdmin="U1247" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS 1414127..1414366 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389381.1" /db_xref="EnsemblGenomes-Gn:BSU14980" /db_xref="EnsemblGenomes-Tr:CAB13371" /db_xref="InterPro:IPR025613" /db_xref="SubtiList:BG13357" /db_xref="UniProtKB/Swiss-Prot:O34958" /translation="MRKEVQEYILANEERKRFIREQPIWYRRLSRKPDDLSSFQLEMM NFYEKTIPHRVNQFTNGIQMAQMMMQMFQAMRTKD*" /label="ylbE CDS" gene 1414127..1414366 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /label="ylbE gene" downshifts 1414345 /Source="Nicolas_upshifts" /id="D849" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="2.09257" /MaxDrop="4.65792" /score="-7.8200921" /energy="-5.1" /TU="NA" /idTUdmin="U1248" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1414433..1414440 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1414451..1414470 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1414456 /Source="Nicolas_upshifts" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1414482..1414931 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex controlling RNase Y (RicAFTcomplex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389382.1" /db_xref="EnsemblGenomes-Gn:BSU14990" /db_xref="EnsemblGenomes-Tr:CAB13372" /db_xref="GOA:O34412" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="SubtiList:BG13358" /db_xref="UniProtKB/Swiss-Prot:O34412" /translation="MYATMESVRLQSEAQQLAEMILQSETAENYRNCYKRLQEDEEAG RIIRSFIKIKEQYEDVQRFGKYHPDYREISRKMREIKRELDLNDKVADFKRAENELQS ILDEVSVEIGTAVSEHVKVPTGNPYFDGLSSCGGGCGSGGSCGCKVS*" /label="ricF CDS" gene 1414482..1414931 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /label="ricF gene" downshifts 1414917 /Source="Nicolas_upshifts" /id="D850" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="5.95111" /MaxDrop="2.83" /score="-4.2014677" /energy="-11.5" /TU="U1249" /idTUdmin="U1248" /TUdmin=572 /isTUend="FALSE" /label="downshifts" CDS 1414986..1415258 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10712692, 21532344, 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389383.1" /db_xref="EnsemblGenomes-Gn:BSU15000" /db_xref="EnsemblGenomes-Tr:CAB13373" /db_xref="GOA:O34658" /db_xref="InterPro:IPR016979" /db_xref="SubtiList:BG13359" /db_xref="UniProtKB/Swiss-Prot:O34658" /translation="MENRRQGMVVYLHSLKQSKMLRKFGNVHYVSKRLKYVVLYCDMD QIEKTMDKIASYSFVKKVEPSYKPFLKLEFESKLDKAKEYDYKIGI*" /label="ylbG CDS" gene 1414986..1415258 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /label="ylbG gene" S_feature complement(1415063..1415286) /Source="Nicolas_S_feature" /locus_tag="new_1569001_1569224_c" /HighExp="S8, S7, S4, S5, S6, S3, C30, BT, G135, C90" /AntisenseName="ylbG" /AntisenseCor="-0.668594452827031" /AntisenseRegPval="-35.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S546" misc_RNA 1415261..1415381 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /product="sporulation-specific regulatory RNA" /experiment="publication(s) with functional evidences, PMID:21532344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21532344; Product type n: RNA" /function="15.7: Sporulation and germination" /label="csfG RNA" gene 1415261..1415381 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /label="csfG gene" S_feature complement(1415288..1415411) /Source="Nicolas_S_feature" /locus_tag="new_1569226_1569349_c" /HighExp="S3, S8, S7, G/S, S4, S5, Pyr, S6, B36, BT" /AntisenseName="NA" /AntisenseCor="-0.69279578575099399" /AntisenseRegPval="-39.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S547" downshifts complement(1415331) /Source="Nicolas_upshifts" /id="D851" /incds=0 /nref=61 /ntot=131 /MaxReadThrough="3.9368" /MaxDrop="7.78892" /score="40.2648817" /energy="-14.3" /TU="U1250" /idTUdmin="U1250" /TUdmin="-228" /isTUend="FALSE" /label="downshifts" S_feature 1415382..1415487 /Source="Nicolas_S_feature" /locus_tag="new_1569320_1569425" /HighExp="H2O2, Paraq, Oxctl, G180, G135, G150, Cold, C30, Diami, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S548" promotor_-10 complement(1415412..1415424) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1415419) /Source="Nicolas_upshifts" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1415439..1415445) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1415468..1415472 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-35" promotor_-10 1415488..1415507 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-10" S_feature 1415489..1415580 /Source="Nicolas_S_feature" /locus_tag="new_1569427_1569518" /HighExp="H2O2, G135, Oxctl, Paraq, G180, dia0, G150, Lbexp, LBGexp, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S549" upshifts 1415489 /Source="Nicolas_upshifts" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="upshifts" CDS 1415581..1416135 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /EC_number="2.1.1.171" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 17389639, 22535590, 22649054; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m2G966 methyltransferase" /protein_id="NP_389384.2" /db_xref="EnsemblGenomes-Gn:BSU15010" /db_xref="EnsemblGenomes-Tr:CAB13374" /db_xref="GOA:O34331" /db_xref="InterPro:IPR004398" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13360" /db_xref="UniProtKB/Swiss-Prot:O34331" /translation="MRVISGSKKGRSLKAVAGTSTRPTTDKVKESIFNMIGPYFDGGR GLDLFAGSGGLGIEALSRGFEHCIFVDRDFKAIQTVKSNLKTLELTKHAQVYRNDAER ALHAAAKRETGFRGIFLDPPYKEQKLKALLTLIDEYQMLEEDGFIVAEHDREVELPET VGDLVMTRKETYGLTGVAIYKKRG*" /label="rsmD CDS" gene 1415581..1416135 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /label="rsmD gene" CDS 1416140..1416625 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /EC_number="2.7.7.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10480925, 10939241, 16014871, 21912874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphopantetheine adenylyltransferase" /protein_id="NP_389385.1" /db_xref="EnsemblGenomes-Gn:BSU15020" /db_xref="EnsemblGenomes-Tr:CAB13375" /db_xref="GOA:O34797" /db_xref="InterPro:IPR001980" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="PDB:1O6B" /db_xref="SubtiList:BG13361" /db_xref="UniProtKB/Swiss-Prot:O34797" /translation="MASIAVCPGSFDPVTYGHLDIIKRGAHIFEQVYVCVLNNSSKKP LFSVEERCELLREVTKDIPNITVETSQGLLIDYAKRKNAKAILRGLRAVSDFEYEMQG TSVNRVLDESIETFFMMTNNQYSFLSSSIVKEVARYNGSVSEFVPPEVELALQQKFRQ G*" /label="coaD CDS" gene 1416140..1416625 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /label="coaD gene" downshifts 1416592 /Source="Nicolas_upshifts" /id="D852" /incds=0 /nref=26 /ntot=196 /MaxReadThrough="3.45558" /MaxDrop="3.85134" /score="13.7782945" /energy="-7.8" /TU="U1249,U1251" /idTUdmin="U1251" /TUdmin="-1296" /isTUend="FALSE" /label="downshifts" CDS complement(1416636..1417862) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15849754, 16850406, 28945739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15849754, 16850406, 28945739; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipicolinic acid transporter (to the spore)" /protein_id="NP_389386.1" /db_xref="EnsemblGenomes-Gn:BSU15030" /db_xref="EnsemblGenomes-Tr:CAB13376" /db_xref="GOA:O34765" /db_xref="InterPro:IPR011642" /db_xref="InterPro:IPR014226" /db_xref="SubtiList:BG13362" /db_xref="UniProtKB/Swiss-Prot:O34765" /translation="MNLSKINTLLIASFFLFLTATVISHPQASFEASKTGLSMWWEVV FPSLLPFFILSELLIGFGIVRFVGVLLEPFMRPIFRVPGVGGFVLAMGMASGNPAGAK LTARLRQENQISRVEAERLASFTNSSNPLFIFGAVAVGFFQNASLGILLASAHYLGNL AVGLTMRSYGRKEEQHLRRKKTIPFPSVKDALHALHTARLAEKRPLGKILGDAVTSSV QTLLMVGGFIILFSVFNRLLSVVQLTDVLSVFTKGALTLFQLPTQLDIPLLSGMFEIT LGSKLVSETDVSLLQKAIIVSFILGFSGFSVQAQVAGILSETDIRFKPFFIARLLQGV YAAVFVMLLWKPLYTAWHDPYQYVFKSLNSSDMSTAFINGWNLLVQIGPAVTLCALFT YIIIFSYRLTNGTKKG*" /label="spoVV CDS" gene complement(1416636..1417862) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /label="spoVV gene" S_feature 1416637..1417911 /Source="Nicolas_S_feature" /locus_tag="new_1570575_1571849" /HighExp="H2O2, G135, Paraq, G150, G180, Oxctl, LBGexp, dia0, dia15, Mt0" /AntisenseName="ylbJ" /AntisenseCor="-0.54237424349391605" /AntisenseRegPval="-21.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S550" S_feature complement(1417863..1417964) /Source="Nicolas_S_feature" /locus_tag="new_1571801_1571902_c" /HighExp="LoTm, S3, S4, S5, T5.0H, M9-stat, T4.0H, S6, BT, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S551" promotor_-35 1417886..1417893 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1417905..1417924 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1417913..1418042 /Source="Nicolas_S_feature" /locus_tag="new_1571851_1571980" /HighExp="Etha, dia15, dia5, Diami, H2O2, Lbtran, LBGtran, Paraq, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S552" upshifts 1417913 /Source="Nicolas_upshifts" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1417959..1417977) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1417974) /Source="Nicolas_upshifts" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1417994..1417999) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1418043..1418825 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389387.1" /db_xref="EnsemblGenomes-Gn:BSU15040" /db_xref="EnsemblGenomes-Tr:CAB13377" /db_xref="GOA:O34731" /db_xref="InterPro:IPR001423" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG13363" /db_xref="UniProtKB/Swiss-Prot:O34731" /translation="MAKPKIGLALGSGGARGLAHLGVLSSLHKHQIEVDMIAGSSMGA LVGSFYAAGHDVATMKKVAKAFKRRLYADYTVPKLGFLKGDRVRQLVHAYTFGKPIEE LQIPLGIVACDLQTGEKIVFRKGSVSDAVRASISIPGIFIPQRLDGRLLVDGAVVDRI PVSVVKDMGADIIIASDVSRVRKTETAVHIFDVIMQSMDILQNELVRHQTIAADIMIR PSLETYSSSSFANIEEMISAGEEATNRMISKIRKEIENWEGS*" /label="ylbK CDS" gene 1418043..1418825 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /label="ylbK gene" promotor_-35 1418605..1418611 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1418625..1418636 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1418636 /Source="Nicolas_upshifts" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1418827..1419852 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradative enzyme" /protein_id="NP_389388.2" /db_xref="EnsemblGenomes-Gn:BSU15050" /db_xref="EnsemblGenomes-Tr:CAB13378" /db_xref="GOA:O34470" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR036034" /db_xref="PDB:2KJP" /db_xref="SubtiList:BG13364" /db_xref="UniProtKB/Swiss-Prot:O34470" /translation="MLRKKHFSWMLVILILIAVLSFIKLPYYITKPGEATELASLIKV EGGYPEKGSLSLMTVKVGPANPFTYVWAKMHPYYEIVPDESIKEEGESDKEYMKRQLQ MMKSSQENAVIAAYQKAGKKVSYSFNGIYASSVVENMPAKGKIEVGDKIISADGKNYQ SAEKLIDYISSKKAGDKVTLKIEREEKEKRVTLTLKQFPDEPDRAGIGVSLYTDRNVK VEPDIDFEIENIGGPSAGLMMSLEIYNQLTKPDETKGYDIAGTGTIDVDGKVGPIGGI DQKVVAADKAGKDIFFAPNQNGASNSDYKNAVKTAKDIDSNMKIVPVDTMQDAIDYLN KLKAKST*" /label="ylbL CDS" gene 1418827..1419852 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /label="ylbL gene" downshifts 1419736 /Source="Nicolas_upshifts" /id="D853" /incds=1 /nref=59 /ntot=235 /MaxReadThrough="2.38639" /MaxDrop="3.52503" /score="19.0874959" /energy="-11.5" /TU="NA" /idTUdmin="U1249" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1419869..1421116) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 19215769; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative component of the degradosome" /protein_id="NP_389389.1" /db_xref="EnsemblGenomes-Gn:BSU15060" /db_xref="EnsemblGenomes-Tr:CAB13379" /db_xref="InterPro:IPR008513" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13365" /db_xref="UniProtKB/Swiss-Prot:O34513" /translation="MKAVGLVVEYNPFHNGHLYHAQTAKLQTGCDTAVAVMSGHFLQR GEPAVVSKWARTKMALQSGVDLVIELPYLYAVQKADIFARGSVSILNELECEALFFGS ENGDIKPFLETAQLIDEHKHILNDRIKEELKKGASYPAAAAIAFSSILHTESALDLSK PNNILGYQYVTSILTGGYPMKPYTTARISSDYHDADLPEGENHIASATSIRKAMIGQN LEACLRFLPAASARELAAYRKSFGLWHTPESYFSYLKYSLSTVTARELQQVYEVEEGL EHRIIRSIRKSSSYQEFMELLKTKRYTWTRLQRMNTHILTRTKKQDMQKLLDNDKAPY IRLLGMTKKGQAYLSEKKKALSVPLVSKLSSFSHPALDLDVKASRIYSLPIEEPLRTE FDLQEYGHAPIRYDEDEQHFLNV*" /label="ylbM CDS" gene complement(1419869..1421116) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /label="ylbM gene" downshifts complement(1419896) /Source="Nicolas_upshifts" /id="D854" /incds=0 /nref=8 /ntot=182 /MaxReadThrough="1.58661" /MaxDrop="3.70777" /score="4.49214865" /energy="-11.5" /TU="NA" /idTUdmin="U1257" /TUdmin=775 /isTUend="FALSE" /label="downshifts" promotor_-35 1421033..1421039 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-35" promotor_-10 1421053..1421064 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-10" upshifts 1421057 /Source="Nicolas_upshifts" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="upshifts" CDS complement(1421113..1421298) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein,of unknown function" /protein_id="YP_003097727.1" /db_xref="EnsemblGenomes-Gn:BSU15069" /db_xref="EnsemblGenomes-Tr:CAX52618" /db_xref="UniProtKB/Swiss-Prot:C0H411" /translation="MIIAFKIVFVNIFSLQHNAAIEVSLTAEYAMHTLKTKIRRKSFH LQMYHTFLNIARKAEKI*" /label="ylzH CDS" gene complement(1421113..1421298) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /label="ylzH gene" promotor_-35 1421131..1421135 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-35" promotor_-10 1421151..1421170 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-10" S_feature 1421160..1421295 /Source="Nicolas_S_feature" /locus_tag="new_1575098_1575233" /HighExp="Cold, LoTm, Diami, Paraq, H2O2, Oxctl, G180, dia5, G135, LBGexp" /AntisenseName="ylzH" /AntisenseCor="-9.1134498265910996E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S553" upshifts 1421160 /Source="Nicolas_upshifts" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="upshifts" promotor_-10 complement(1421189..1421208) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1421199) /Source="Nicolas_upshifts" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1421222..1421229) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1421266..1421273 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1421287..1421306 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1421297 /Source="Nicolas_upshifts" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1421326..1421844 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11700356, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389390.1" /db_xref="EnsemblGenomes-Gn:BSU15070" /db_xref="EnsemblGenomes-Tr:CAB13380" /db_xref="InterPro:IPR003772" /db_xref="SubtiList:BG13366" /db_xref="UniProtKB/Swiss-Prot:O34445" /translation="MKWTIYQLHQMPKQSFEFDETVELNELTKLNSDIRRISPVRVKG RADIKSKQVSFDFTISGEMLLPCSRTLVDVPYPFEISTKELFIFHHTDDIEDDDVHIV EDDTIDITPIVKEEILLEIPMQIFCESEQEKGAAPQEGKDWQVISEEDKKNQVDPRLA ALEKLLKQDDES*" /label="ylbN CDS" gene 1421326..1421844 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /label="ylbN gene" CDS 1421866..1422045 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L32" /protein_id="NP_389391.1" /db_xref="EnsemblGenomes-Gn:BSU15080" /db_xref="EnsemblGenomes-Tr:CAB13381" /db_xref="GOA:O34687" /db_xref="InterPro:IPR002677" /db_xref="InterPro:IPR011332" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12668" /db_xref="UniProtKB/Swiss-Prot:O34687" /translation="MAVPFRRTSKMKKRLRRTHFKLNVPGMTECPSCGEMKLSHRVCK ACGSYNGKDINVKSN*" /label="rpmF CDS" gene 1421866..1422045 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /label="rpmF gene" downshifts 1422025 /Source="Nicolas_upshifts" /id="D855" /incds=0 /nref=232 /ntot=266 /MaxReadThrough="5.64002" /MaxDrop="7.70407" /score="53.0065581" /energy="-17.1" /TU="U1258" /idTUdmin="U1256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1422068) /Source="Nicolas_upshifts" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1422072..1422075) /Source="Nicolas_upshift_promotors" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1422126..1422131 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1422147..1422165 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1422148 /Source="Nicolas_upshifts" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1422191..1422772 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15621419, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15621419, 20435725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="DNA-binding regulator" /protein_id="NP_389392.1" /db_xref="EnsemblGenomes-Gn:BSU15090" /db_xref="EnsemblGenomes-Tr:CAB13382" /db_xref="GOA:O34549" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017930" /db_xref="SubtiList:BG13367" /db_xref="UniProtKB/Swiss-Prot:O34549" /translation="MTITRQDAWTQDEDLLLAEVVLRHIREGGTQLSAFEEVGRALTR TAAACGFRWNSYVRKQYQSGIELAKKQRKELRKQIGVHSVNMPNSMKQTASASSEGKR DLSIQDVIQFLEQFKETPSAQEFQLEREKLKEQIQSLQKELEDLRSENQTLRNQLEMT EEDYKALIDIMDRARKMVVSKEDGRMKKAAQET*" /label="gerR CDS" gene 1422191..1422772 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /label="gerR gene" downshifts 1422773 /Source="Nicolas_upshifts" /id="D856" /incds=0 /nref=56 /ntot=139 /MaxReadThrough="2.70626" /MaxDrop="5.6861" /score="-7.71867756" /energy="-12.8" /TU="U1260" /idTUdmin="U1258" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1422829..1423311) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389393.2" /db_xref="EnsemblGenomes-Gn:BSU15100" /db_xref="EnsemblGenomes-Tr:CAB13383" /db_xref="GOA:O34468" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017274" /db_xref="PDB:2PR1" /db_xref="SubtiList:BG13368" /db_xref="UniProtKB/Swiss-Prot:O34468" /translation="MTKVERLLINYKTLEEFKKFKEYGIQELSMLEELQDNIIENDST SPFYGIYFGDKLVARMSLYQVNGKSNPYFDNRQDYLELWKLEVLPGYQNRGYGRALVE FAKSFKMPIRTNPRMKSAEFWNKMNFKTVKYDMARDKGENPLIWHPDMDREMTPGESA *" /label="ylbP CDS" gene complement(1422829..1423311) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /label="ylbP gene" downshifts complement(1422848) /Source="Nicolas_upshifts" /id="D857" /incds=0 /nref=90 /ntot=231 /MaxReadThrough="3.90092" /MaxDrop="6.59996" /score="14.5482917" /energy="-14.5" /TU="U1261" /idTUdmin="U1261" /TUdmin="-615" /isTUend="FALSE" /label="downshifts" downshifts 1423301 /Source="Nicolas_upshifts" /id="D858" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.3013" /MaxDrop="4.42908" /score="-7.71867756" /energy="-12.8" /TU="NA" /idTUdmin="U1260" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1423334..1423353) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1423353) /Source="Nicolas_upshifts" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1423367..1423374) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1423411..1423417 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-35" promotor_-10 1423429..1423448 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-10" upshifts 1423431 /Source="Nicolas_upshifts" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="upshifts" CDS 1423471..1424367 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1844812, 10736170, 23894131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1844812, 10736170, 23894131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate 2-reductase" /protein_id="NP_389394.1" /db_xref="EnsemblGenomes-Gn:BSU15110" /db_xref="EnsemblGenomes-Tr:CAB13384" /db_xref="GOA:O34661" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="PDB:3EGO" /db_xref="SubtiList:BG13369" /db_xref="UniProtKB/Swiss-Prot:O34661" /translation="MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIR LYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQSVFSSLERIGKTNILFLQNGMGH IHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHN HSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEAC RILKLENEEKAWERVQAVCGQTKENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLD AVHLEFLYGSIKALERNTNKVF*" /label="panE CDS" gene 1423471..1424367 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /label="panE gene" CDS 1424438..1426057 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /EC_number="6.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16169927, 19578333, 20308541, 20799687, 25496067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16169927, 19578333, 20308541, 20799687, 25496067; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate glucosamine cysteine ligase" /protein_id="NP_389395.2" /db_xref="EnsemblGenomes-Gn:BSU15120" /db_xref="EnsemblGenomes-Tr:CAB13385" /db_xref="GOA:P55342" /db_xref="InterPro:IPR011199" /db_xref="PDB:4WBD" /db_xref="SubtiList:BG11424" /db_xref="UniProtKB/Swiss-Prot:P55342" /translation="MQLTELSIKNQNVFVQHYIDGKEEMSSFFDYSIHHKDMWRERLE DLSSRFFAREELAAYLTSYHNKFGSSAMQSAIEKLKDPSSAAVVGGQQAGLLTGPLYT IHKIISIIVLAKQQEKELQVPVIPIFWVAGEDHDLDEINFVHTSEENGPVKKKLPQSY WKKSSAASTSLDQEKCAAWIDDVFAAFEETDHTNTLLDNVKRCLRESVTFTDFFELLI ADLFQEEGLVLLNSGDPGIKKLETAMFQKILRENDELARAVSDQQAFMRQAGYKPIIE SGKEQANLFYEYEDERFLIEKDNGRFVIKELDLGWTRDELHTHMEEHPERFSNNVVTR PLMQEFLIPTLAFIAGPGEINYWGELKQAFAVMGFKMPPVMPRLNITILERHIEKKLA ERNISLQDAIERGTENQRETYFERQIPEEFTAVMDQAKSQIEAIHKTVRQEALKVDQS LEPLLLKNAAFIQDQLQFLERTVMKRIEEKEGYVLKDYERIQNSIKPLLAPQERIWNI MYYLNRYGPKFFTTFKNLPFSFQNQHQVVKL*" /label="bshC CDS" gene 1424438..1426057 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /label="bshC gene" downshifts 1426029 /Source="Nicolas_upshifts" /id="D859" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="3.87099" /MaxDrop="3.76832" /score="34.9463932" /energy="-8.3" /TU="U1262" /idTUdmin="U1262" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 1426091..1426094 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1426109..1426182 /Source="Nicolas_S_feature" /locus_tag="new_1580047_1580120" /HighExp="M9-stat, T5.0H, T3.0H, Lbstat, Lbtran, T2.30H, T1.30H, M0t90, T1.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="SigA" /TUlongPSig=1 /label="S554" promotor_-10 1426109..1426128 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1426109 /Source="Nicolas_upshifts" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1426166) /Source="Nicolas_upshifts" /id="D860" /incds=0 /nref=17 /ntot=137 /MaxReadThrough="3.30554" /MaxDrop="4.47473" /score="-9.92306593" /energy="-12" /TU="NA" /idTUdmin="U1264" /TUdmin=1149 /isTUend="FALSE" /label="downshifts" CDS 1426183..1426614 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /function="16.13: Shape" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10572301, 15939023, 16511046, 24659771, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of RsmH and transcriptional regulator" /protein_id="NP_389396.1" /db_xref="EnsemblGenomes-Gn:BSU15130" /db_xref="EnsemblGenomes-Tr:CAB13386" /db_xref="GOA:P55343" /db_xref="InterPro:IPR003444" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR020603" /db_xref="InterPro:IPR035642" /db_xref="InterPro:IPR035644" /db_xref="SubtiList:BG11425" /db_xref="UniProtKB/Swiss-Prot:P55343" /translation="MFMGEYQHTIDAKGRMIVPAKFREGLGEQFVLTRGLDQCLFGYP MHEWKQIEEKLKALPLTKKDARAFTRFFFSGATECELDKQGRVNIASSLLNYAKLEKE CVVIGVSNRIELWSKVIWEQYTEEQEDSFAEIAENMIGFDI*" /label="mraZ CDS" gene 1426183..1426614 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /label="mraZ gene" CDS 1426684..1427619 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /EC_number="2.1.1.199" /function="16.6: Maintain" /function="16.13: Shape" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9294438, 9721276, 10572301, 16849811, 19965768, 20924196, 22561317, 27711192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m4C1402 methyltransferase" /protein_id="NP_389397.1" /db_xref="EnsemblGenomes-Gn:BSU15140" /db_xref="EnsemblGenomes-Tr:CAB13387" /db_xref="GOA:Q07876" /db_xref="InterPro:IPR002903" /db_xref="InterPro:IPR023397" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10219" /db_xref="UniProtKB/Swiss-Prot:Q07876" /translation="MFQHKTVLLRETVDGLNIKPDGTYVDCTLGGAGHSTYLLQQLSE KGRLIAFDQDDTALQHAKEVLSDYKGQLILIKSNFRYLKEYLNEQGVTEVDGILFDLG VSSPQLDTPERGFSYHHDAPLDMRMDQSATLSAKEVVNEWRYEDLVRIFFKYGEEKFS KQIARKIEEARMKSPIQTTGQLVDLIKDAIPAPARRSGGHPAKRVFQAIRIAVNDELR VFEEALEQAIEVLKPGGRVSVITFHSLEDRICKTTFKEKSSLPELPPGLPVIPEEFEP ELKLITRKPITASQEELEENNRARSAKLRIAEKRK*" /label="rsmH CDS" gene 1426684..1427619 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /label="rsmH gene" S_feature complement(1427286..1428738) /Source="Nicolas_S_feature" /locus_tag="new_1581224_1582676_c" /HighExp="Salt, Sw, B60, Etha, M9-stat, Gly, C30, LPhT, BC, B36" /AntisenseName="ftsL" /AntisenseCor="-0.195961042435877" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S555" CDS 1427659..1428012 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein" /protein_id="NP_389398.1" /db_xref="EnsemblGenomes-Gn:BSU15150" /db_xref="EnsemblGenomes-Tr:CAB13388" /db_xref="GOA:Q07867" /db_xref="InterPro:IPR011922" /db_xref="SubtiList:BG10220" /db_xref="UniProtKB/Swiss-Prot:Q07867" /translation="MSNLAYQPEKQQRHAISPEKKVIVKKRASITLGEKVLLVLFAAA VLSVSLLIVSKAYAAYQTNIEVQKLEEQISSENKQIGDLEKSVADLSKPQRIMDIAKK NGLNLKDKKVKNIQE*" /label="ftsL CDS" gene 1427659..1428012 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /label="ftsL gene" CDS 1428009..1430159 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8636036, 10411726, 12682299, 14731276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636036, 10411726, 12682299, 14731276; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2B" /protein_id="NP_389399.2" /db_xref="EnsemblGenomes-Gn:BSU15160" /db_xref="EnsemblGenomes-Tr:CAB13389" /db_xref="GOA:Q07868" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10221" /db_xref="UniProtKB/Swiss-Prot:Q07868" /translation="MIQMPKKNKFMNRGAAILSICFALFFFVILGRMAYIQITGKANG EVLATKATEQHEKKRTIEASRGSILDRKGKVIAEDTATYKLIAILDKKMTTDVKHPQH VVNKEKTAEALSKVINLDKADILDILNKDAKQVEFGSAGRDITYSQKQKIEKMKLPGI SFLRDTKRYYPNGVFASNLIGYAEVDEETNEISGAMGLEKVLDKYLKERDGYVTYESD KSGWELPNSKNKITAPKNGDNVYLTIDQKIQTFLEDSMTKVAQKYNPKKIMAAVVDPK TGKVLAMGQRPSFDPNKRDVTNYYNDLISYAYEPGSTMKIFTLAAAMQENVFNANEKY KSGTFEVGGAPVKDHNNGVGWGPTTYHDGVLRSSNVAFAKLAKEKLGYDRLNQYLHKF NFYQKTGIDLPGEVSSKINFKYEFDKASTAYGQASAVTPIQQIQAATAIANDGKMMKP YVIDHIVDPDKDKTIYQNKPESAGTPISASTAKKVRDILGEVVTSKIGTGQAYKIEGF DVAGKTGTAQIAGKGGYLDGTDNYIFSFMGMAPKDDPELLIYVAVQQPQLKAGQSSSD PVSEIFNPTMKNSLHYLNIEPTEKSDSDKEETKAQTMPDLTDQTVAAAQKKAKEENLT PIVIGSDVAVKEQYPKADEEVLTNQKVFLKTGGKIKMPDMTGWSRREVLQYGELAGIH IEVSGQGYAVSQSVKKDKEIKDKTVIKVKFKNPD*" /label="pbpB CDS" gene 1428009..1430159 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /label="pbpB gene" promotor_-10 complement(1428719..1428737) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1428738) /Source="Nicolas_upshifts" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1428752..1428758) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1430142 /Source="Nicolas_upshifts" /id="D861" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="1.141" /MaxDrop="6.28059" /score="3.41058446" /energy="-7.4" /TU="NA" /idTUdmin="U1263" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1430214..1430219 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-35" promotor_-10 1430235..1430253 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-10" upshifts 1430235 /Source="Nicolas_upshifts" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="upshifts" CDS 1430276..1432216 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8244929, 8289242, 9006059, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8244929, 8289242, 9006059, 28383125; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transpeptidase penicillin-binding protein" /protein_id="NP_389400.2" /db_xref="EnsemblGenomes-Gn:BSU15170" /db_xref="EnsemblGenomes-Tr:CAB13390" /db_xref="GOA:Q03524" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR011927" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10222" /db_xref="UniProtKB/Swiss-Prot:Q03524" /translation="MRVSNVTVRKRLLFVLLFGVIVFLIIDTRLGYVQFVMGEKLTSL AKDSWSRNLPFEPERGEILDRNGVKLATNKSAPTVFVVPRQVQNPMKTSKQLAAVLNM SEEKVYKHVTKKASIEKITPEGRKISNEKAKEIKALDLKGVYVAEDSIRHYPFGSFLS HVLGFAGIDNQGLLGLEAYYDDDLKGEKGSVKFYTDAKGKKMPDEADDYTPPKDGLDM KLTVDSKVQTIMERELDNAEAKYHPDGMIAVAMNPKNGEILGMSSRPDFDPADYQSVD PSVYNRNLPVWSTYEPGSTFKIITLAAALEEQKVNLKRDQFYDKGHAEVDGARLRCWK RGGHGLQTYLEVVQNSCNPGFVELGERLGKEKLFKYIKDFGFGQKTGIDLQGEGTGIL FPLERVGPVEQATTAFGQGVSVTPIQQVAAVSAAVNGGTLYTPYIAKEWIDPVTKKTV KKQSPIAKKQVISEETSKQIRYALESVVAEGTGRNAFVEGYRVGGKTGTAQKVKDGKY LENNHIVSFIGFAPADDPSLVVYVAVDNPKGTIQFGGTVAAPIVGNIMRDSLPELGVK PRKNQIEKKYQWNDTKTIEVPNVVGMSVSDLESLLVNLNVDASGKGSKIVKQSPAAGT KVKEGSKIRVYLTEEDEKEAAD*" /label="spoVD CDS" gene 1430276..1432216 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /label="spoVD gene" promotor_-35 1432012..1432018 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-35" promotor_-10 1432033..1432041 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-10" upshifts 1432039 /Source="Nicolas_upshifts" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="upshifts" downshifts 1432189 /Source="Nicolas_upshifts" /id="D862" /incds=0 /nref=19 /ntot=91 /MaxReadThrough="4.23549" /MaxDrop="4.37308" /score="-3.90592085" /energy="-13.6" /TU="U1265,U1266" /idTUdmin="U1265" /TUdmin="-91" /isTUend="FALSE" /label="downshifts" S_feature 1432234..1432301 /Source="Nicolas_S_feature" /locus_tag="new_1586172_1586239" /HighExp="C30, G180, G135, ferm, MG 15, G150, MG 45, MG-0.1, MG 10, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S556" promotor_-35 1432271..1432275 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1432291..1432310 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" S_feature 1432303..1432391 /Source="Nicolas_S_feature" /locus_tag="new_1586241_1586329" /HighExp="G180, G150, LBGexp, Paraq, G135, Oxctl, C30, dia0, Cold, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S557" upshifts 1432303 /Source="Nicolas_upshifts" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" CDS 1432392..1433876 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /EC_number="6.3.2.13" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8436954, 10520745, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase" /protein_id="NP_389401.1" /db_xref="EnsemblGenomes-Gn:BSU15180" /db_xref="EnsemblGenomes-Tr:CAB13391" /db_xref="GOA:Q03523" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005761" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10223" /db_xref="UniProtKB/Swiss-Prot:Q03523" /translation="MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVK GYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKL QLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQK TFKKMNDKHVDTAIMEVSSHALSLGRVHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAK SLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDADVMAKNISIT AQGTSFDLVTNKGTKHITMSLVGQFNVYNVLAAVATCIAAGIPFEIITEAVEELHGVR GRFELVNQQQEFPVIVDYAHTPDSLENVLETCRDMTEGKLFVVVGCGGDRDKTKRPKM AKIAVELADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIANREQAIFFAIANAKK GDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS*" /label="murE CDS" gene 1432392..1433876 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /label="murE gene" S_feature 1433877..1433987 /Source="Nicolas_S_feature" /locus_tag="new_1587815_1587925" /HighExp="G180, G135, G150, C30, Oxctl, dia0, LBGexp, MG 25, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S558" CDS 1433988..1434962 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /EC_number="2.7.8.13" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospho-N-acetylmuramoyl-pentapeptide undecaprenyl phosphate (C55P) transferase" /protein_id="NP_389402.2" /db_xref="EnsemblGenomes-Gn:BSU15190" /db_xref="EnsemblGenomes-Tr:CAB13392" /db_xref="GOA:Q03521" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR003524" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG10224" /db_xref="UniProtKB/Swiss-Prot:Q03521" /translation="MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKS HQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIK VVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVL FMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFL VFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFK TTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL*" /label="mraY CDS" gene 1433988..1434962 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /label="mraY gene" CDS 1434963..1436318 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /EC_number="6.3.2.9" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1765076, 9218784, 10966819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate ligase" /protein_id="NP_389403.1" /db_xref="EnsemblGenomes-Gn:BSU15200" /db_xref="EnsemblGenomes-Tr:CAB13393" /db_xref="GOA:Q03522" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005762" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10225" /db_xref="UniProtKB/Swiss-Prot:Q03522" /translation="MENDQFLQKQHFLILGLAKSGYAAASILHEKGIYVAVNDQKPFE ENEPAQKLSEKGIEVVCGEHPVSLFDQHQITILIKNPGIPYENIMVQEAEKRGIPVWT EIELAYYLTSAKFIGITGSNGKTTTTTLIYEMLKADSQKALIAGNIGTVASEVAYHAD GDEWIVTELSSFQLMGTHAFRPEISLILNVFDAHLDYHHTRENYEKAKQKVYLHQTAS DKAIVNQDDETVVRLAEAGKAEIVPFSVSKTLEQGAYVKDSMIMFNGEAILPLEEVVL PGAHNLENILAAIAVVKTAGASNEAVKKVLTSFTGVKHRLQYVTTVNGRKFYNDSKAT NILATSKALSAFDKPVILLAGGLDRGNGFDDLKPYMKHVKAVLTFGQTAPKLEKLGNE LGIQHVKRVDNVEQAVSAAFALSNEGDVILLSPACASWDQFKTFEERGDMFIDAVHML K*" /label="murD CDS" gene 1434963..1436318 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /label="murD gene" promotor_-35 1436142..1436147 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-35" promotor_-10 1436163..1436181 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-10" upshifts 1436173 /Source="Nicolas_upshifts" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="upshifts" CDS 1436379..1437479 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:2509435, 9622350, 15849754, 16484183, 16850406, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509435, 9622350, 15849754, 16484183, 16850406, 27312048; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="factor for spore cortex peptidoglycan synthesis (stage V sporulation)" /protein_id="NP_389404.1" /db_xref="EnsemblGenomes-Gn:BSU15210" /db_xref="EnsemblGenomes-Tr:CAB13394" /db_xref="GOA:P07373" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR013437" /db_xref="InterPro:IPR013438" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10226" /db_xref="UniProtKB/Swiss-Prot:P07373" /translation="MTTKKTSPDLLLVIITLLLLTIGLIMVYSASAVWADYKFDDSFF FAKRQLLFAGIGVIAMFFIMNVDYWTWRTWSKLLMVICFFLLVLVLIPGVGMVRNGSR SWIGVGAFSIQPSEFMKLAMIAFLAKFLSEKQKNITSFRRGFVPALGIVFSAFLIIMC QPDLGTGTVMVGTCIVMIFVAGARIAHFVFLGLIGLSGFVGLVLSAPYRIKRITSYLN PWEDPLGSGFQIIQSLYAVGPGGLFGMGLGQSRQKFFYLPEPQTDFIFAILSEELGFI GGTLILLLFSVLLWRGIRIALGAPDLYGSFVAVGIISMIAIQVMINIGVVTGLIPVTG ITLPFLSYGGSSLTLMLMAVGVLLNVSRYSRY*" /label="spoVE CDS" gene 1436379..1437479 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /label="spoVE gene" S_feature 1437480..1437601 /Source="Nicolas_S_feature" /locus_tag="new_1591418_1591539" /HighExp="G180, C30, G135, G150, Oxctl, Paraq, LBGexp, dia0, S3, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-" /TUshortPSig="0.569, 1, 0.436" /TUlongSig="NA" /TUlongPSig="NA" /label="S559" CDS 1437602..1438693 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /EC_number="2.4.1.227" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9244290, 11042447, 12538870, 12682299, 12813070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9244290, 11042447, 12538870, 12682299, 12813070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine-N-acetylmuramyl- (pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" /protein_id="NP_389405.2" /db_xref="EnsemblGenomes-Gn:BSU15220" /db_xref="EnsemblGenomes-Tr:CAB13395" /db_xref="GOA:P37585" /db_xref="InterPro:IPR004276" /db_xref="InterPro:IPR006009" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10227" /db_xref="UniProtKB/Swiss-Prot:P37585" /translation="MRIAISGGGTGGHIYPALAFIKEVQRRHPNVEFLYIGTENGLEK KIVERENIPFRSIEITGFKRKLSFENVKTVMRFLKGVKKSKSYLAEFKPDAVIGTGGY VCGPVVYAAAKMGIPTIVHEQNSLPGITNKFLSKYVNKVAICFEEAKSHFPSEKVVFT GNPRASEVVSIKTGRSLAEFGLSEDKKTVLIFGGSRGAAPINRAVIDMQDVLKTRDYQ VLYITGEVHYEKVMNELKSKGAADNMVTKPFLHQMPEYLKAIDVIVARAGATTIAEIT ALGIPSVLIPSPYVTANHQEVNARSLGQHDAAIVLKETELSGEKLIEALDRIVLNEQT LKEMSERTKSLGVPDAAARLYSVLEELKK*" /label="murG CDS" gene 1437602..1438693 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /label="murG gene" promotor_-35 1438082..1438091 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1438104..1438119 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1438109 /Source="Nicolas_upshifts" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" promotor_no_box 1438115..1438215 /Source="Nicolas_upshift_promotors" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1438175 /Source="Nicolas_upshifts" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1438725..1439636 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /EC_number="1.3.1.98" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11327854, 12682299, 16484183, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylenolpyruvoylglucosamine reductase" /protein_id="NP_389406.1" /db_xref="EnsemblGenomes-Gn:BSU15230" /db_xref="EnsemblGenomes-Tr:CAB13396" /db_xref="GOA:P18579" /db_xref="InterPro:IPR003170" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR011601" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036635" /db_xref="SubtiList:BG10228" /db_xref="UniProtKB/Swiss-Prot:P18579" /translation="MEKVIQELKEREVGKVLANEPLANHTTMKIGGPADVLVIPSSVD AVKDIMDVIKKYDVKWTVIGRGSNLLVLDEGIRGVVIKLGAGLDHLELEGEQVTVGGG YSVVRLATSLSKKGLSGLEFAAGIPGSVGGAVYMNAGAHGSDMSEILVKAHILFEDGT IEWLTNEQMDFSYRTSVLQKKRPGVCLEAVLQLEQKDKESIVQQMQSNKDYRKNTQPY SSPCAGSIFRNPLPNHAGNLVEKAGLKGYQIGGAKISEMHGNFIVNAGGASAKDVLDL IDHVKKTIREKYEIDMHTEVEIIGGNR*" /label="murB CDS" gene 1438725..1439636 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /label="murB gene" downshifts 1439654 /Source="Nicolas_upshifts" /id="D863" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="5.78428" /MaxDrop="2.8642" /score="-7.67573434" /energy="-7.4" /TU="U1267,U1268,U1269,U1270" /idTUdmin="U1266" /TUdmin=1809 /isTUend="FALSE" /label="downshifts" CDS 1439766..1440557 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389407.1" /db_xref="EnsemblGenomes-Gn:BSU15240" /db_xref="EnsemblGenomes-Tr:CAB13397" /db_xref="GOA:P16655" /db_xref="InterPro:IPR005548" /db_xref="InterPro:IPR013685" /db_xref="InterPro:IPR026580" /db_xref="InterPro:IPR034746" /db_xref="SubtiList:BG10229" /db_xref="UniProtKB/Swiss-Prot:P16655" /translation="MNPGQDREKIVNIEERIPKIKEQRKQKANRRLISFIMLFFIMVL IIVYLQTPISKVSTISVTGNENVSKKEIIDLSDINSGDTEFWSLDKQKTEKKIQQNKL VKKAEISKSLPNKINIAIEEYKAIAYLEKDDVYYEVLENGSVLPNEVTPDDAGPILVN WTNAKKRSQMAKQLDALSNSLKQSISEIYYTPVKMDENRIKLYMNDGYVVTASIKTFA DRMKTYPSIISQLSSNKKGIIHLEVATYFEEFGKNDKAAKKEDEN*" /label="divIB CDS" gene 1439766..1440557 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /label="divIB gene" CDS 1440554..1441249 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389408.2" /db_xref="EnsemblGenomes-Gn:BSU15250" /db_xref="EnsemblGenomes-Tr:CAB13398" /db_xref="GOA:C0SPA3" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11490" /db_xref="UniProtKB/Swiss-Prot:C0SPA3" /translation="MRGKSAVLLSLIMLIAGFLISFSFQMTKENNKSAAETEEWKKEY ALRDELLKQEKENKKFEKELYQKQNKVRQAENKLKKEKSEYYNVLEDTEKYRMYIGEV GVQGEGVEVTLEDASYIPEGENVNSYIVHESHIFQVVNELYISGAAAVAVNGQRLTHD SYIKCNGPVVTVDGVQHPAPFTVSAIGDPDVLLPSLNIAGGLIDQLSMDHISVSAEKE KNVQMKPILKTKE*" /label="ylxW CDS" gene 1440554..1441249 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /label="ylxW gene" CDS 1441272..1441979 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183, 18179421" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389409.2" /db_xref="EnsemblGenomes-Gn:BSU15260" /db_xref="EnsemblGenomes-Tr:CAB13399" /db_xref="GOA:Q45544" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11489" /db_xref="UniProtKB/Swiss-Prot:Q45544" /translation="MKIKRSFISISVLMVIFGLMISVQFNSLKHPKVRDTRDMWDIRE ELTSEQKKQEKLLAEINKYDKLLNSYSQTKEMTKETALNNTLQSLKKTAGMTDITGSG IVITISPLFSESLTGEPIENPPPDLLKKLINELNSYGAEHISINERRVVNHTVIRDIN GTTKIDGYALDDYPLTVKVLAKDPDMLHSRVKGSGLEDLFASENLALKAGKSESKLTL KAYDRPLDVQQLKLLKD*" /label="ylxX CDS" gene 1441272..1441979 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /label="ylxX gene" CDS 1441997..1442362 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1569582, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (small basic protein)" /protein_id="NP_389410.1" /db_xref="EnsemblGenomes-Gn:BSU15270" /db_xref="EnsemblGenomes-Tr:CAB13400" /db_xref="GOA:P28265" /db_xref="InterPro:IPR009709" /db_xref="SubtiList:BG10230" /db_xref="UniProtKB/Swiss-Prot:P28265" /translation="MWLPVLGLVLGIAIGLMTNLTIPSEYSNYLSLAVLAALDTLIGG IRAHLQGTYDEMVFVSGFFFNIILAISLAFLGVHLGVDLYLAGIFAFGVRLFQNIAVI RRNLLTKWTLSKKNKKNVI*" /label="sbp CDS" gene 1441997..1442362 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /label="sbp gene" promotor_-35 1442214..1442217 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1442233..1442252 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1442249 /Source="Nicolas_upshifts" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" S_feature 1442363..1442535 /Source="Nicolas_S_feature" /locus_tag="new_1596301_1596473" /HighExp="T3.0H, T2.30H, S2, T3.30H, Lbtran, T4.0H, T5.0H, T1.30H, S1, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigWXY, SigA" /TUshortPSig="0.989, 0.0739, 1, 1" /TUlongSig="SigEF, Sig-" /TUlongPSig="0.569, 0.436" /label="S560" CDS 1442536..1443858 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein essential for Z-ring assembly" /protein_id="NP_389411.2" /db_xref="EnsemblGenomes-Gn:BSU15280" /db_xref="EnsemblGenomes-Tr:CAB13401" /db_xref="GOA:P28264" /db_xref="InterPro:IPR003494" /db_xref="InterPro:IPR020823" /db_xref="SubtiList:BG10231" /db_xref="UniProtKB/Swiss-Prot:P28264" /translation="MNNNELYVSLDIGTSNTKVIVGEMTDDSLNIIGVGNVPSEGLKK GSIVDIDETVHSIRKAFDQAERMVGFPLRKAIVGVNGNYINIQDTNGVVAVSSENKEI QVEDVRRVMEAAQVVSVPHEQLIVDVIPKQFIVDGRDEITDPKKMLGVRLEVEGTLIT GSKTILHNLLRCVERAGIEITDICLQPLAAGSAALSKDEKNLGVALIDIGGGSTTIAV FQNGHLTSTRVIPLGGENITKDISIGLRTSTEEAERVKKQLGHAYYDEASEDEIFEVT VIGTNQKQTFTQQEAANIIEARVEEILEIVSEELRSMGITDLPGGFVLTGGQAAMPGV MSLAQDVLQNNVRVASPNYIGVRDPQYMTGVGLIQFACRNARIQGRKIGFKMPEEAIQ EIAVSSSEEQEQHHHQNEVQQRPKGKQKTQAEHNKQSKMKKLLSMFWE*" /label="ftsA CDS" gene 1442536..1443858 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /label="ftsA gene" upshifts complement(1442743) /Source="Nicolas_upshifts" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1442747..1442751) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1442766..1442770) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1443894..1445042 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389412.2" /db_xref="EnsemblGenomes-Gn:BSU15290" /db_xref="EnsemblGenomes-Tr:CAB13402" /db_xref="GOA:P17865" /db_xref="InterPro:IPR000158" /db_xref="InterPro:IPR003008" /db_xref="InterPro:IPR008280" /db_xref="InterPro:IPR018316" /db_xref="InterPro:IPR020805" /db_xref="InterPro:IPR024757" /db_xref="InterPro:IPR036525" /db_xref="InterPro:IPR037103" /db_xref="PDB:2RHH" /db_xref="PDB:2RHJ" /db_xref="PDB:2RHL" /db_xref="PDB:2RHO" /db_xref="PDB:2VAM" /db_xref="PDB:2VXY" /db_xref="PDB:4U39" /db_xref="SubtiList:BG10232" /db_xref="UniProtKB/Swiss-Prot:P17865" /translation="MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVN TDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVT AGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDT LIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIM SNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQ EAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSI KTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG*" /label="ftsZ CDS" gene 1443894..1445042 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /label="ftsZ gene" downshifts 1445016 /Source="Nicolas_upshifts" /id="D864" /incds=0 /nref=226 /ntot=389 /MaxReadThrough="2.85051" /MaxDrop="7.70428" /score="34.7919519" /energy="-13.7" /TU="U1267,U1271" /idTUdmin="U1269" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" SCAR join(1445137,1445144) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs20" N_region 1445138..1445143 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs20" S_feature <1445144..1445189 /Source="Nicolas_S_feature" /locus_tag="new_1606413_1606501" /HighExp="LoTm, S7, S8, BT, S6, S4, G/S, S3, S2, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S565" promotor_-35 1445154..1445161 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1445174..1445193 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1445191 /Source="Nicolas_upshifts" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1445248..1446042 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683, 18083814; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389417.2" /db_xref="EnsemblGenomes-Gn:BSU15340" /db_xref="EnsemblGenomes-Tr:CAB13408" /db_xref="GOA:O31723" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13370" /db_xref="UniProtKB/Swiss-Prot:O31723" /translation="MILQLDNVSLKRNGKWILKDIHWKVEEKENWVLYGLNGAGKTAL LNMLCSYYFPTSGEMQVLGHEFGKTELGEKLRRKIGLVSAALQQKLYPADSAFEIALS GAYASIGLYETPSKETREKAIGLLEDLGAIEYADRRYETLSQGEKQRALIARALMADP ELLILDEPVTGLDFIAREKLLDTITYIANKENAPSILYVTHHAEEILPVFDKALLLKQ GEVFGSGEIKEMLTDQILSAFFDTPIHVLWNQDRPFLTRAEPITNA*" /label="ylmA CDS" gene 1445248..1446042 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /label="ylmA gene" promotor_-35 1445960..1445963 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-35" promotor_-10 1445978..1445997 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-10" upshifts 1445986 /Source="Nicolas_upshifts" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="upshifts" misc_RNA 1446055..1446156 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswE RNA" gene 1446055..1446156 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /label="tswE gene" downshifts 1446143 /Source="Nicolas_upshifts" /id="D867" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="5.58534" /MaxDrop="4.3688" /score="-2.39598083" /energy="-7.1" /TU="U1278,U1279" /idTUdmin="U1274" /TUdmin=971 /isTUend="FALSE" /label="downshifts" CDS 1446244..1447524 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /EC_number="3.5.1.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17618314" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17618314; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-4-amino-5-aminomethyl-2- methylpyrimidinedeformylase" /protein_id="NP_389418.2" /db_xref="EnsemblGenomes-Gn:BSU15350" /db_xref="EnsemblGenomes-Tr:CAB13409" /db_xref="GOA:O31724" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13371" /db_xref="UniProtKB/Swiss-Prot:O31724" /translation="MDQQIYSLQKKVEEHKEELIQLAKTLISYQTPAPPARNTEGIQS WIAGYLNELGFSIDKWDVYPGDPNVVGKLKGTDSADYYSLIINGHVDVAEVKEDEEWK HDPFHPIEKNGLLIGRGASDMKGGMACVLFAVKLIREASIELPGDLILQSVIGEEVGE AGTLECCKRGYHADFAIVADTSDMHIQGQGGVITGWIEIKSSQTFHDGTRRNMIHAGG GTFGASAIEKMAKIIAGLGELERHWSIMKSYPGFKPGTNTINPAVIEGGRHAAFIADE CRLWITVHFYPNETHDQVAAEIEDYVNRLSDSDIWLRENRPVFKWGGSSMIEDRGEIF PALEVDPGHPGVLALTASHQKVKRECPIIDVSQSVTDGGWLYDAGIPCVIYGPGDLHN AHSVNEKVSIEQLVEYTKIILDFIISWCSRKKEQ*" /label="thiQ CDS" gene 1446244..1447524 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /label="thiQ gene" misc_feature complement(1447465..1447481) /Source="Nicolas_upshift_promotors" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1447470) /Source="Nicolas_upshifts" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1447545..1447550 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-35" promotor_-10 1447566..1447584 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-10" upshifts 1447570 /Source="Nicolas_upshifts" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="upshifts" CDS 1447607..1447852 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /experiment="publication(s) with functional evidences, PMID:12429060, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12429060, 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="essential sporulation protein" /protein_id="NP_389419.1" /db_xref="EnsemblGenomes-Gn:BSU15360" /db_xref="EnsemblGenomes-Tr:CAB13410" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13372" /db_xref="UniProtKB/Swiss-Prot:O31725" /translation="MISISEFQVKDVVNVSNGKKLGSIGDIDINVTTGKIQAIILGGN GKVLGFFGKEEELVIPWRNIVKIGEDVILVRLSEPHA*" /label="ylmC CDS" gene 1447607..1447852 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /label="ylmC gene" promotor_-35 1447768..1447776 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1447787..1447805 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1447795 /Source="Nicolas_upshifts" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1447853..1447963 /Source="Nicolas_S_feature" /locus_tag="new_1609165_1609275" /HighExp="T3.0H, S2, S1, T4.0H, T3.30H, T5.0H, T2.0H, BC, Gly, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34150000000000003" /TUshortSig="SigH, SigEF, SigA, SigA" /TUshortPSig="1, 0.998, 0.976, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S566" misc_feature 1447955..1447974 /Source="Nicolas_upshift_promotors" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1447965 /Source="Nicolas_upshifts" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1448015..1448851 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16498617, 19737354; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved protein with laccase domain" /protein_id="NP_389420.1" /db_xref="EnsemblGenomes-Gn:BSU15370" /db_xref="EnsemblGenomes-Tr:CAB13411" /db_xref="GOA:O31726" /db_xref="InterPro:IPR003730" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG13373" /db_xref="UniProtKB/Swiss-Prot:O31726" /translation="MNTYHPFSLTTPSTLMIQDWAQTNQNNKEVIAGFTTKNGGVSQK PFESLNTGLHVHDKDADVVKNREYIADMFNTDLQSWVFADQTHDNRVQKVTQRDRGKG AREYHTALKATDGIYTNEKNVFLALCFADCVPLFFYDPVKSLVGVAHAGWKGTVKQIG REMVKQWTEKEGSNPSDIYAVIGPSISGACYTVDDRVMDAVRALPVSADLAANQTAKA QYQLDLKELNRLILMDSGLASEQISVSGLCTESEPSLFYSHRRDQGKTGRMMSFIGMK EA*" /label="ylmD CDS" gene 1448015..1448851 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /label="ylmD gene" CDS 1448858..1449550 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14526035, 24097949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PLP-containing enzyme" /protein_id="NP_389421.1" /db_xref="EnsemblGenomes-Gn:BSU15380" /db_xref="EnsemblGenomes-Tr:CAB13412" /db_xref="GOA:O31727" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR011078" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG13374" /db_xref="UniProtKB/Swiss-Prot:O31727" /translation="MRVVDNLRHINERINEACNRSGRSSDEVTVIAVTKYVSPERAQE AVDAGITCLGENRDAELLRKQELMKGNPEWHFIGSLQSRKAKSVVNSVSYIHSLDRLS LAKEIEKRAEGTVRCFVQVNTSLEPSKHGMKKEEVIPFIQELSGFEHILVAGLMTMAP LTDDQDQIRSCFRSLRELRDQVQKLNQPNAPCTELSMGMSNDFEIAIEEGATYIRIGS SLVGNETGGVQQ*" /label="ylmE CDS" gene 1448858..1449550 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /label="ylmE gene" CDS 1449547..1450002 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14526035, 16420366, 16796675, 18782755, 22912848, 24218584" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526035, 16420366, 16796675, 18782755, 22912848, 24218584; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division machinery factor" /protein_id="NP_389422.3" /db_xref="EnsemblGenomes-Gn:BSU15390" /db_xref="EnsemblGenomes-Tr:CAB13413" /db_xref="GOA:O31728" /db_xref="InterPro:IPR007561" /db_xref="InterPro:IPR023052" /db_xref="PDB:3ZIH" /db_xref="PDB:3ZII" /db_xref="SubtiList:BG13375" /db_xref="UniProtKB/Swiss-Prot:O31728" /translation="MSMKNKLKNFFSMEDEEYEYEYIETERESHEEHEQKEKPAYNGN KPAGKQNVVSLQSVQKSSKVVLSEPRVYAEAQEIADHLKNRRAVVVNLQRIQHDQAKR IVDFLSGTVYAIGGDIQRIGSDIFLCTPDNVDVSGTISELISEDEHQRW*" /label="sepF CDS" gene 1449547..1450002 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /label="sepF gene" CDS 1450009..1450281 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14526035, 19966467, 20359373; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, distribution of nucleoids and osmotic tolerance" /protein_id="NP_389423.1" /db_xref="EnsemblGenomes-Gn:BSU15400" /db_xref="EnsemblGenomes-Tr:CAB13414" /db_xref="GOA:O31729" /db_xref="InterPro:IPR003425" /db_xref="SubtiList:BG13376" /db_xref="UniProtKB/Swiss-Prot:O31729" /translation="MILYQVFSVLSLLITIYSFALIIYIFMSWVPSTRETAVGRFLAS ICEPYLEPFRKIIPPIAMLDISPIVAILVLRFATTGLWGLYRMIAF*" /label="ylmG CDS" gene 1450009..1450281 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /label="ylmG gene" downshifts 1450270 /Source="Nicolas_upshifts" /id="D868" /incds=0 /nref=16 /ntot=97 /MaxReadThrough="6.19839" /MaxDrop="4.93537" /score="-6.17078585" /energy="-15.2" /TU="U1278,U1281,U1282,U1283" /idTUdmin="U1281" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" CDS 1450342..1451115 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10093218, 14526035, 21141807; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, RNA-binding fold" /protein_id="NP_389424.1" /db_xref="EnsemblGenomes-Gn:BSU15410" /db_xref="EnsemblGenomes-Tr:CAB13415" /db_xref="GOA:P71020" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11856" /db_xref="UniProtKB/Swiss-Prot:P71020" /translation="MSDIYQHFRKDERAFIDQALEWKRIVQEQYRMKLTDFLDPREQV ILSAVTGQADVGLAFSGGYDRAERKRAILFPEYITPEESDFELQAFNVRYADKFVSVD HRSLLGALMGIGLKRQKFGDIVFSETAVQLIVSADTADFVAAQLTQAGKAAVSLEKID LSDLNIPAVDVEIRDDTVSSLRLDAVCASMSRQSRQKSQTLVKNGLVKVNWKVVEDPS YIVAEGDMLSIRGFGRCSLTKIEGKTKKDKWRVTFERQK*" /label="ylmH CDS" gene 1450342..1451115 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /label="ylmH gene" promotor_-35 1450831..1450838 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1450852..1450870 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1450875 /Source="Nicolas_upshifts" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1451116..1451208 /Source="Nicolas_S_feature" /locus_tag="new_1612428_1612520" /HighExp="C90, M0t90, C30, GM-0.1, Glucon, MG 5, GM 45, GM 5, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigH, SigEF, SigA" /TUshortPSig="0.973, 1, 1, 0.998, 0.989" /TUlongSig="SigA" /TUlongPSig="0.976" /label="S567" CDS 1451209..1451703 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389425.1" /db_xref="EnsemblGenomes-Gn:BSU15420" /db_xref="EnsemblGenomes-Tr:CAB13416" /db_xref="GOA:P71021" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR019933" /db_xref="PDB:2WUJ" /db_xref="PDB:2WUK" /db_xref="SubtiList:BG11835" /db_xref="UniProtKB/Swiss-Prot:P71021" /translation="MPLTPNDIHNKTFTKSFRGYDEDEVNEFLAQVRKDYEIVLRKKT ELEAKVNELDERIGHFANIEETLNKSILVAQEAAEDVKRNSQKEAKLIVREAEKNADR IINESLSKSRKIAMEIEELKKQSKVFRTRFQMLIEAQLDLLKNDDWDHLLEYEVDAVF EEKE*" /label="divIVA CDS" gene 1451209..1451703 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /label="divIVA gene" promotor_-35 1451716..1451723 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1451737..1451756 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1451744 /Source="Nicolas_upshifts" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1451766..1451992 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /product="T-box riboswitch specific of isoleucine tRNA" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /label="iswA RNA" gene 1451766..1451992 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /label="iswA gene" downshifts 1451959 /Source="Nicolas_upshifts" /id="D869" /incds=0 /nref=43 /ntot=100 /MaxReadThrough="7.76706" /MaxDrop="5.97038" /score="48.8352635" /energy="-19.4" /TU="U1278,U1282,U1283,U1284,U1285" /idTUdmin="U1281" /TUdmin=237 /isTUend="FALSE" /label="downshifts" CDS 1452045..1454810 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /EC_number="6.1.1.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16697013, 17043414, 17095543, 28139725; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucyl-tRNA synthetase" /protein_id="NP_389426.2" /db_xref="EnsemblGenomes-Gn:BSU15430" /db_xref="EnsemblGenomes-Tr:CAB13417" /db_xref="GOA:Q45477" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002301" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023585" /db_xref="InterPro:IPR033708" /db_xref="SubtiList:BG11792" /db_xref="UniProtKB/Swiss-Prot:Q45477" /translation="MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERT KDRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIE TALTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEY EAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDG KGVLENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASAC GFDQYEVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDF IIGQKYGLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHS YPHDWRTKKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDW CISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFT HPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSL STAVAVTGKAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSV DYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNAVAVEDLREVDQYMLI KLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSM QTVFYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEK FDRFMALRDDVLKALETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVS ELTISEENEAPNDAQSFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEI VEKYYQK*" /label="ileS CDS" gene 1452045..1454810 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /label="ileS gene" downshifts 1454801 /Source="Nicolas_upshifts" /id="D870" /incds=0 /nref=233 /ntot=261 /MaxReadThrough="2.6695" /MaxDrop="6.91924" /score="40.2175565" /energy="-13.9" /TU="NA" /idTUdmin="U1278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(1454856) /Source="Nicolas_upshifts" /id="D871" /incds=0 /nref=6 /ntot=17 /MaxReadThrough="1.29709" /MaxDrop="3.66645" /score="13.8608728" /energy="-15.6" /TU="NA" /idTUdmin="U1275" /TUdmin="-12534" /isTUend="FALSE" /label="downshifts" promotor_-35 1454891..1454897 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-35" promotor_-10 1454912..1454923 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-10" upshifts 1454912 /Source="Nicolas_upshifts" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="upshifts" CDS 1454955..1455329 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15496987, 23123912, 23678950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15496987, 23123912, 23678950; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related RNA polymerase-binding factor" /protein_id="NP_389427.2" /db_xref="EnsemblGenomes-Gn:BSU15440" /db_xref="EnsemblGenomes-Tr:CAB13418" /db_xref="GOA:Q45478" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR016841" /db_xref="InterPro:IPR020458" /db_xref="SubtiList:BG11795" /db_xref="UniProtKB/Swiss-Prot:Q45478" /translation="MNDQLTAIYTELLLMKEELQSRLFEYSCFQVSTSPQAAINQKQK ATLIYHIKEELQDVLLALSKIENGTFGYCEETGAPIPLAKLAVLPTARTANDFLYSVQ FEKKTLPIWKSTDIEYGQALYE*" /label="ylyA CDS" gene 1454955..1455329 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /label="ylyA gene" promotor_-35 1455361..1455365 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" upshifts 1455380 /Source="Nicolas_upshifts" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" promotor_-10 1455381..1455400 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" CDS 1455432..1455896 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /EC_number="3.4.23.36" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9880550, 9882689, 10497172, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880550, 9882689, 10497172, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="signal peptidase II" /protein_id="NP_389428.1" /db_xref="EnsemblGenomes-Gn:BSU15450" /db_xref="EnsemblGenomes-Tr:CAB13419" /db_xref="GOA:Q45479" /db_xref="InterPro:IPR001872" /db_xref="SubtiList:BG11793" /db_xref="UniProtKB/Swiss-Prot:Q45479" /translation="MLYYMIALLIIAADQLTKWLVVKNMELGQSIPIIDQVFYITSHR NTGAAWGILAGQMWFFYLITTAVIIGIVYYIQRYTKGQRLLGVALGLMLGGAIGNFID RAVRQEVVDFIHVIIVNYNYPIFNIADSSLCVGVMLLFIQMLLDSGKKKKEQ*" /label="lspA CDS" gene 1455432..1455896 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /label="lspA gene" CDS 1455898..1456809 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15078091, 15928344, 17188032, 17937767, 18032607, 20817755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389429.3" /db_xref="EnsemblGenomes-Gn:BSU15460" /db_xref="EnsemblGenomes-Tr:CAB13420" /db_xref="GOA:Q45480" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11796" /db_xref="UniProtKB/Swiss-Prot:Q45480" /translation="MNQIDITASEEQKSERIDKFLASTENDWSRTQVQQWVKDGQVVV NGSAVKANYKIQPGDQVTVTVPEPEALDVLAEPMDLDIYYEDQDVLVVNKPRGMVVHP APGHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDTSGLLMVAKNDMAHESLVNQ LVNKTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTVTRDGKNAVTHFHVLERF QDFTLVECQLETGRTHQIRVHMKYIGFPLAGDPKYGPRKTIDFNGQALHAGVLGFDHP RTGEYVEFEAPLPEDMAELIENLRKNG*" /label="rluD CDS" gene 1455898..1456809 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /label="rluD gene" promotor_-35 1456804..1456811 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" promotor_-10 1456826..1456845 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" upshifts 1456840 /Source="Nicolas_upshifts" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" misc_RNA 1456849..1456965 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaA RNA" gene 1456849..1456965 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /label="pyaA gene" CDS 1456992..1457537 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /EC_number="2.4.2.9" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7798145, 9932459, 12482852, 15716449, 17322189, 18678934" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 9932459, 12482852, 15716449, 17322189, 18678934; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional attenuator and uracil phosphoribosyltransferase activity" /protein_id="NP_389430.1" /db_xref="EnsemblGenomes-Gn:BSU15470" /db_xref="EnsemblGenomes-Tr:CAB13421" /db_xref="GOA:P39765" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR023050" /db_xref="InterPro:IPR029057" /db_xref="PDB:1A3C" /db_xref="PDB:1A4X" /db_xref="PDB:4P82" /db_xref="SubtiList:BG10712" /db_xref="UniProtKB/Swiss-Prot:P39765" /translation="MNQKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGI YLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSKKTSNDEPLVKGADIPVDITDQKVI LVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSE KVMVQLDEVDQNDLVAIYENE*" /label="pyrR CDS" gene 1456992..1457537 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /label="pyrR gene" downshifts complement(1457186) /Source="Nicolas_upshifts" /id="D872" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="1.85132" /MaxDrop="2.50006" /score="0.812637138" /energy="-7" /TU="NA" /idTUdmin="U1275" /TUdmin="-14864" /isTUend="FALSE" /label="downshifts" downshifts 1457528 /Source="Nicolas_upshifts" /id="D873" /incds=0 /nref=13 /ntot=149 /MaxReadThrough="8.16191" /MaxDrop="3.4492" /score="16.3570883" /energy="-11.5" /TU="U1287,U1288" /idTUdmin="U1286" /TUdmin=704 /isTUend="FALSE" /label="downshifts" misc_RNA 1457541..1457658 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaB RNA" gene 1457541..1457658 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /label="pyaB gene" CDS 1457711..1459018 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8206848, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uracil permease" /protein_id="NP_389431.2" /db_xref="EnsemblGenomes-Gn:BSU15480" /db_xref="EnsemblGenomes-Tr:CAB13422" /db_xref="GOA:P39766" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR029935" /db_xref="SubtiList:BG10992" /db_xref="UniProtKB/Swiss-Prot:P39766" /translation="MSKKKVNLGVRDVPTPFSWVSFSLQHLFAMFGSTILVPKLVGMS PAVALVTSGIGTLAYLLITKGQIPAYLGSSFAFISPIILVKATGGPGAAMVGAFLAGL VYGLIALLIRQLGTGWLMKILPPVVVGPVIIVIGLGLASTAVNMAMYADPNASELVYS LKHFSVAGVTLAITIICAIFLRGFLSLIPVLIGIIGGYLFALTQGIVNFQPVLDAKWF AVPEFIIPFKDYSPSVTLGIAAAMVPVAFVTMSEHIGHQMVLSKVVGQDFIKKPGLHR SIMGDSVATILASLIGGPPTTTYGENIGVLAITRVFSVFVIGGAAVIALCFGFIGKIS ALISSVPSAVMGGVSFLLFGIIASSGLRMLIDNKIDYENNRNLIITSVILVIGVGGAF IQVSQGGFQVSGMALAAIVGVILNLILPQAKEEQADTSEQHHI*" /label="pyrP CDS" gene 1457711..1459018 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /label="pyrP gene" misc_RNA 1459019..1459133 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaC RNA" gene 1459019..1459133 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /label="pyaC gene" CDS 1459164..1460078 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /EC_number="2.1.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8535162, 16321950, 21663747" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8535162, 16321950, 21663747; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate carbamoyltransferase" /protein_id="NP_389432.2" /db_xref="EnsemblGenomes-Gn:BSU15490" /db_xref="EnsemblGenomes-Tr:CAB13423" /db_xref="GOA:P05654" /db_xref="InterPro:IPR002082" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR036901" /db_xref="PDB:2AT2" /db_xref="PDB:3R7D" /db_xref="PDB:3R7F" /db_xref="PDB:3R7L" /db_xref="SubtiList:BG10713" /db_xref="UniProtKB/Swiss-Prot:P05654" /translation="MKHLTTMSELSTEEIKDLLQTAQELKSGKTDNQLTGKFAANLFF EPSTRTRFSFEVAEKKLGMNVLNLDGTSTSVQKGETLYDTIRTLESIGVDVCVIRHSE DEYYEELVSQVNIPILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSR VARSNAEVLTRLGARVLFSGPSEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQ SAVSQEGYLNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKN GVFIRMAVIQRALQTNVKRGEAAYVISH*" /label="pyrB CDS" gene 1459164..1460078 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /label="pyrB gene" CDS 1460062..1461348 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /EC_number="3.5.2.3" /function="2: Purines, pyrimidines, nucleosides, and nucleotides" /experiment="publication(s) with functional evidences, PMID:7516791, 16522191, 21045288" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7516791, 16522191, 21045288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotase" /protein_id="NP_389433.2" /db_xref="EnsemblGenomes-Gn:BSU15500" /db_xref="EnsemblGenomes-Tr:CAB13424" /db_xref="GOA:P25995" /db_xref="InterPro:IPR002195" /db_xref="InterPro:IPR004722" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10714" /db_xref="UniProtKB/Swiss-Prot:P25995" /translation="MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVI DAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKE QMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGM MYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVL LAEAANCHYHVCHISTKESVRVVRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKM NPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLL YTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETF LSKGKNTPFNGISCTGWPVATIAAGKLAYEEGRLVK*" /label="pyrC CDS" gene 1460062..1461348 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /label="pyrC gene" CDS 1461345..1462439 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1709162, 11390694, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit)" /protein_id="NP_389434.1" /db_xref="EnsemblGenomes-Gn:BSU15510" /db_xref="EnsemblGenomes-Tr:CAB13425" /db_xref="GOA:P25993" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10715" /db_xref="UniProtKB/Swiss-Prot:P25993" /translation="MKRRLVLENGAVFEGEAFGSLEHNMGEVVFNTGMTGYQEILSDP SYCGQIVTLTYPLIGNYGINRDDFESITPFVKGLIIKELCELPSNWRSAYTLDEYLKM KNIPGLQGIDTRKLTRMIRTAGALKGTFASSDEDIEAVLKRLNETELPRNQVSQVSAK TAYPSPGRGKRIVLVDFGMKHGILRELNKRKCDVIVVPYNITAEEVLQLKPDGIMLSN GPGDPKDVPEAIEMIKGVLGKVPLFGICLGHQLFALACGANTEKMKFGHRGSNHPVKE LATGKVALTSQNHGYTVSSISKTELEVTHIAINDDTIEGLKHKTLPAFTVQYHPEASP GPEDANHLFDRFIEMIETTEKEGEAVCQNA*" /label="pyrAA CDS" gene 1461345..1462439 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /label="pyrAA gene" CDS 1462424..1465639 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 216664, 6120161, 10732707, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (large subunit)" /protein_id="NP_389435.1" /db_xref="EnsemblGenomes-Gn:BSU15520" /db_xref="EnsemblGenomes-Tr:CAB13426" /db_xref="GOA:P25994" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR033937" /db_xref="InterPro:IPR036897" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10716" /db_xref="UniProtKB/Swiss-Prot:P25994" /translation="MPKRVDINKILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYEV ILVNSNPATIMTDTEMADRVYIEPLTPEFLTRIIRKERPDAILPTLGGQTGLNLAVEL SERGVLAECGVEVLGTKLSAIQQAEDRDLFRTLMNELNEPVPESEIIHSLEEAEKFVS QIGFPVIVRPAYTLGGTGGGICSNETELKEIVENGLKLSPVHQCLLEKSIAGYKEIEY EVMRDSQDHAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNVSLKLIRALG IEGGCNVQLALDPDSFQYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLSLDEM MNPVTGKTYAAFEPALDYVVSKIPRWPFDKFESANRKLGTQMKATGEVMAIGRTLEES LLKAVRSLEADVYHLELKDAADISDELLEKRIKKAGDERLFYLAEAYRRGYTVEDLHE FSAIDVFFLHKLFGIVQFEKELKANAGDTDVLRRAKELGFSDQYISREWKMKESELYS LRKQAGIAPVFKMVDTCAAEFESETPYFYSTYEEENESVVTDKKSVMVLGSGPIRIGQ GVEFDYATVHSVWAIKQAGYEAIIVNNNPETVSTDFSISDKLYFEPLTIEDVMHIIDL EQPMGVVVQFGGQTAINLADELSARGVKILGTSLEDLDRAEDRDKFEQALGELGVPQP LGKTATSVNQAVSIASDIGYPVLVRPSYVLGGRAMEIVYHEEELLHYMKNAVKINPQH PVLIDRYLTGKEIEVDAVSDGETVVIPGIMEHIERAGVHSGDSIAVYPPQSLTEDIKK KIEQYTIALAKGLNIVGLLNIQFVLSQGEVYVLEVNPRSSRTVPFLSKITGIPMANLA TKIILGQKLAAFGYTEGLQPEQQGVFVKAPVFSFAKLRRVDITLGPEMKSTGEVMGKD STLEKALYKALIASGIQIPNYGSVLLTVADKDKEEGLAIAKRFHAIGYNILATEGTAG YLKEASIPAKVVGKIGQDGPNLLDVIRNGEAQFVINTLTKGKQPARDGFRIRRESVEN GVACLTSLDTAEAILRVLESMTFRADQMPAVNTNQEAAVTI*" /label="pyrAB CDS" gene 1462424..1465639 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /label="pyrAB gene" CDS 1465636..1466406 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /EC_number="1.3.98.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:169225, 10545205, 11188687, 15299876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 169225, 10545205, 11188687, 15299876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (electron transfer subunit)" /protein_id="NP_389436.1" /db_xref="EnsemblGenomes-Gn:BSU15530" /db_xref="EnsemblGenomes-Tr:CAB13427" /db_xref="GOA:P25983" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR012165" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR019480" /db_xref="InterPro:IPR023455" /db_xref="InterPro:IPR037117" /db_xref="SubtiList:BG10717" /db_xref="UniProtKB/Swiss-Prot:P25983" /translation="MKKAYLTVCSNQQIADRVFQMVLKGELVQGFTTPGQFLHLKVSE AVTPLLRRPISIADVNFEKNEVTIIYRVDGEGTRLLSLKQQGELVDVLGPLGNGFPVN EVQPGKTALLVGGGVGVPPLQELSKRLIEKGVNVIHVLGFQSAKDVFYEEECRQYGDT YVATADGSYGETGFVTDVIKRKKLEFDILLSCGPTPMLKALKQEYAHKEVYLSMEERM GCGIGACFACVCHTNESETSYVKVCLDGPVFKAQEVAL*" /label="pyrK CDS" gene 1465636..1466406 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /label="pyrK gene" CDS 1466406..1467341 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /EC_number="1.3.1.15" /experiment="publication(s) with functional evidences, PMID:4380263, 10545205" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4380263, 10545205; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (catalytic subunit)" /protein_id="NP_389437.1" /db_xref="EnsemblGenomes-Gn:BSU15540" /db_xref="EnsemblGenomes-Tr:CAB13428" /db_xref="GOA:P25996" /db_xref="InterPro:IPR001295" /db_xref="InterPro:IPR005720" /db_xref="InterPro:IPR012135" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024920" /db_xref="InterPro:IPR033888" /db_xref="SubtiList:BG10718" /db_xref="UniProtKB/Swiss-Prot:P25996" /translation="MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKA TTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQ VDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPV YVKLSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAV KPVAIRMVYEVSQMVNIPIIGMGGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEI IEQLPSVLLQYGYQSIEECIGRSWNHEKQPAHHRA*" /label="pyrD CDS" gene 1466406..1467341 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /label="pyrD gene" CDS 1467310..1468029 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /EC_number="4.1.1.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10681442, 11390694, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10681442, 11390694, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotidine 5'-phosphate decarboxylase" /protein_id="NP_389438.1" /db_xref="EnsemblGenomes-Gn:BSU15550" /db_xref="EnsemblGenomes-Tr:CAB13429" /db_xref="GOA:P25971" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014732" /db_xref="InterPro:IPR018089" /db_xref="PDB:1DBT" /db_xref="SubtiList:BG10719" /db_xref="UniProtKB/Swiss-Prot:P25971" /translation="MKNNLPIIALDFASAEETLAFLAPFQQEPLFVKVGMELFYQEGP SIVKQLKERNCELFLDLKLHDIPTTVNKAMKRLASLGVDLVNVHAAGGKKMMQAALEG LEEGTPAGKKRPSLIAVTQLTSTSEQIMKDELLIEKSLIDTVVHYSKQAEESGLDGVV CSVHEAKAIYQAVSPSFLTVTPGIRMSEDAANDQVRVATPAIAREKGSSAIVVGRSIT KAEDPVKAYKAVRLEWEGIKS*" /label="pyrF CDS" gene 1467310..1468029 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /label="pyrF gene" CDS 1468008..1468658 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /EC_number="2.4.2.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9305779, 22447609, 23405251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotate phosphoribosyltransferase" /protein_id="NP_389439.1" /db_xref="EnsemblGenomes-Gn:BSU15560" /db_xref="EnsemblGenomes-Tr:CAB13430" /db_xref="GOA:P25972" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR004467" /db_xref="InterPro:IPR023031" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10720" /db_xref="UniProtKB/Swiss-Prot:P25972" /translation="MGGNQILKQIIAKHLLDIQAVFLRPNEPFTWASGILSPIYCDNR LTLSFPEVRNDVASGISKLVKEHFPEAEMIAGTATAGIPHAALAADHLNLPMCYVRSK PKAHGKGNQIEGAVQEGQKTVVIEDLISTGGSVLEACAALQAAGCEVLGVVSIFTYGL PKAEEAFAKAELPYYSLTDYDTLTEVALENGNIHSDDLKKLQTWKRNPESKDWFKK*" /label="pyrE CDS" gene 1468008..1468658 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /label="pyrE gene" downshifts 1468660 /Source="Nicolas_upshifts" /id="D874" /incds=0 /nref=17 /ntot=184 /MaxReadThrough="3.91018" /MaxDrop="5.49939" /score="33.4515727" /energy="-9" /TU="U1287,U1288" /idTUdmin="U1287" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" S_feature 1468705..1468777 /Source="Nicolas_S_feature" /locus_tag="new_1630017_1630089" /HighExp="Cold, Gly, MG 5, S0, LPh, M/G, GM 60, MG t5, Mal, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S568" promotor_-35 1468757..1468764 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1468778..1468797 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1468779 /Source="Nicolas_upshifts" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1468803..1468908 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /label="mswE RNA" gene 1468803..1468908 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /label="mswE gene" S_feature 1468909..1469069 /Source="Nicolas_S_feature" /locus_tag="new_1630221_1630381" /HighExp="MG 10, B60, MG 5, MG t5, M9-exp, MG 25, MG 60, MG 15, GM 90, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S569" CDS 1469070..1469771 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10094622, 11004190, 12072441, 16267287, 18456801" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 11004190, 12072441, 16267287, 18456801; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(phospho)adenosine phosphosulfate reductase" /protein_id="NP_389440.1" /db_xref="EnsemblGenomes-Gn:BSU15570" /db_xref="EnsemblGenomes-Tr:CAB13431" /db_xref="GOA:P94498" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11930" /db_xref="UniProtKB/Swiss-Prot:P94498" /translation="MLTYDNWEEPTITFPEDDPYKGALSVLKWAYGHYGDQLVYACSF GIEGIVLIDLIYKVKKDAEIVFLDTGLHFKETYETIERVKERYPGLNIILKKPDLTLE EQAEEHGDKLWEREPNQCCYLRKVVPLREALSGHPAWLSGLRRDQGPSRANTNFLNKD EKFKSVKVCPLIHWTWKDIWRYTSRNELDYNPLHDQGYPSIGCAPCTSPAFTAEDLRS GRWNGMAKTECGLHE*" /label="cysH CDS" gene 1469070..1469771 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /label="cysH gene" CDS 1469783..1470847 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 10784039, 11004190, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 10784039, 11004190, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfate permease" /protein_id="NP_389441.1" /db_xref="EnsemblGenomes-Gn:BSU15580" /db_xref="EnsemblGenomes-Tr:CAB13432" /db_xref="GOA:O34734" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13377" /db_xref="UniProtKB/Swiss-Prot:O34734" /translation="MELAAILFSLFFAMNIGASGAAASMGVAYGSGAIKKKTYALILC AVGVFAGAVIGGGEVVKTISSGIIPEQTITLTIVCIIIGAAALSLFTANLLGIPLSTS EVTVGAVVGVGVAYKVLFVNNLLIIVSFWVFVPLFAFGFTYFVSKLFRYFKIEVKSSK KQKILGIVLLVAGFFEAFSAGMNNVANAVGPLVAAGVLDVGKGTLYGGAFVALGALLL GRRVLETNGKKITRFSKGEGILLSGTGAGLVIISSVFGMPVPLAQVTSSSIIGIGMAK NGPNVFHKQVVQTMLKVWIVSPFLSLSISYLLVSLFLKADYYSIFIMVSVLLAAGGAI SLTKAIRKERRSVHEQGGGI*" /label="cysP CDS" gene 1469783..1470847 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /label="cysP gene" CDS 1470896..1472044 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /EC_number="2.7.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 11004190, 11274114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfate adenylyltransferase" /protein_id="NP_389442.1" /db_xref="EnsemblGenomes-Gn:BSU15590" /db_xref="EnsemblGenomes-Tr:CAB13433" /db_xref="GOA:O34764" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13378" /db_xref="UniProtKB/Swiss-Prot:O34764" /translation="MSLAPHGGTLVNRVDESYDVSGIQKEIELDLISFADLELIGIGA YSPIEGFFNEKDYVSVVENMRLSSGVVWSLPITLPVDAQKAAELSLGETVKLTYEGET YGVIQIEDLYVPDKQKEAVNVYKTDEQEHPGVKKLFSRGNTYVGGPITLIKKASKQFP EFTFEPSETRRQFAEKGWETIVGFQTRNPVHRAHEYIQKTALETVDGLFLNPLVGETK SDDIPADVRMESYQVLLDHYYPKDRVFLGVFLAAMRYAGPREAIFHALVRKNYGCTHF IVGRDHAGVGDYYGTYEAQELFDTFKPEELGITPLKFEHSFFCKKCGNMGTAKTCPHG REHHVILSGTKVRGMLRDGVLPPAEFSRKEVVEVLIKGMKKKEEVGVS*" /label="sat CDS" gene 1470896..1472044 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /label="sat gene" upshifts complement(1470985) /Source="Nicolas_upshifts" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1470997..1471001) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1471019..1471020) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1472057..1472650 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /EC_number="2.7.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1332767, 10094622, 11004190, 19067028, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylylsulfate kinase" /protein_id="NP_389443.1" /db_xref="EnsemblGenomes-Gn:BSU15600" /db_xref="EnsemblGenomes-Tr:CAB13434" /db_xref="GOA:O34577" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13379" /db_xref="UniProtKB/Swiss-Prot:O34577" /translation="MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIAN AAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDRKENIRRIGEVAKLFVQQGTIVI TAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGI DSPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS*" /label="cysC CDS" gene 1472057..1472650 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /label="cysC gene" S_feature 1472651..1472748 /Source="Nicolas_S_feature" /locus_tag="new_1633963_1634060" /HighExp="MG 10, B36, MG 5, MG t5, B60, MG 15, MG 90, MG-0.2, MG 60, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S570" CDS 1472749..1473522 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /EC_number="2.1.1.107" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1906874, 11004190, 10094622, 19154787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III and precorrin-1 C-methyltransferase" /protein_id="NP_389444.1" /db_xref="EnsemblGenomes-Gn:BSU15610" /db_xref="EnsemblGenomes-Tr:CAB13435" /db_xref="GOA:O34744" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG13380" /db_xref="UniProtKB/Swiss-Prot:O34744" /translation="MGKVYIVGAGPGDPDLLTIKALKAIEKADVILYDRLVNKEILQY AKEQADLIYCGKLPDFHTMKQETINRFLVKYAQKGKMVVRLKGGDPFVFGRGGEEAEC LSENGIPFEIIPGITSGIAAAAYAGIPVTHRDAGSNVAFVTGHYKKEEDFEEKWKALA TGIDTLVIYMGIKNVQQIERKLLENGRDGSTPAAFIHWGTTDKQKSVFCTVDTLSETV IKENITNPSLIVIGNVVNYHYKLEWFESELKKQDLSEAL*" /label="sumT CDS" gene 1472749..1473522 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /label="sumT gene" promotor_-35 1473427..1473434 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1473449..1473468 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1473450 /Source="Nicolas_upshifts" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" CDS 1473525..1474310 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /EC_number="4.99.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirohydrochlorin ferrochelatase" /protein_id="NP_389445.1" /db_xref="EnsemblGenomes-Gn:BSU15620" /db_xref="EnsemblGenomes-Tr:CAB13436" /db_xref="GOA:O34632" /db_xref="InterPro:IPR002762" /db_xref="SubtiList:BG13381" /db_xref="UniProtKB/Swiss-Prot:O34632" /translation="MKQAILYVGHGSRVKKAQQEAAAFLEGCKAHISVPVQEISFLEL QEPTIETGFEACVKQGATHIAVVPLLLLTAAHAKHDIPEEIVRVASRYPSVRISYGKP IGIDEEVVKAVYHRMKDIGVPYENARVVLIGRGSSDPDVKRDVTGIANLLQEMVPVKE VIPCFLTACGPNYKEVFSELEKDDGITTFIVPYLLFTGMLMNEIEREVQKLKAHNPNV YLSSYIGFHPHVKNAFLNRVRETAANSEGQFDFDGGSYASAAH*" /label="sirB CDS" gene 1473525..1474310 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /label="sirB gene" CDS 1474291..1474779 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /EC_number="1.3.1.76" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752, 18588505; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="precorrin-2 dehydrogenase" /protein_id="NP_389446.1" /db_xref="EnsemblGenomes-Gn:BSU15630" /db_xref="EnsemblGenomes-Tr:CAB13437" /db_xref="GOA:O34813" /db_xref="InterPro:IPR006367" /db_xref="InterPro:IPR028161" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13382" /db_xref="UniProtKB/Swiss-Prot:O34813" /translation="MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVE PEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSD AELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRR KK*" /label="sirC CDS" gene 1474291..1474779 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /label="sirC gene" downshifts 1474759 /Source="Nicolas_upshifts" /id="D875" /incds=0 /nref=256 /ntot=267 /MaxReadThrough="2.85828" /MaxDrop="8.90139" /score="26.5923498" /energy="-16.6" /TU="U1289" /idTUdmin="U1291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1474806) /Source="Nicolas_upshifts" /id="D876" /incds=0 /nref=149 /ntot=238 /MaxReadThrough="1.71588" /MaxDrop="5.36964" /score="15.559144" /energy="-16.6" /TU="NA" /idTUdmin="U1292" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1474819..1476537) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11238985, 17586671, 24646681, 28294433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA modification protein" /protein_id="NP_389447.1" /db_xref="EnsemblGenomes-Gn:BSU15640" /db_xref="EnsemblGenomes-Tr:CAB13438" /db_xref="InterPro:IPR008532" /db_xref="SubtiList:BG13383" /db_xref="UniProtKB/Swiss-Prot:O34693" /translation="MHMSFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAK GKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIM IFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLP GQDYKLPPAQDKISPLEASEDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRAG LANKVTLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELL DRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELL TANLYMLKKGDKQAEVINYYDEESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVV EEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPKQQKGQKKQKPHNP VLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQT IMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPNGAKPGFVTYDSQHTVFVTPDADTV IKLKKS*" /label="fbnA CDS" gene complement(1474819..1476537) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /label="fbnA gene" promotor_-10 complement(1476559..1476578) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1476573..1476578 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-35" upshifts complement(1476573) /Source="Nicolas_upshifts" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1476591..1476596) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1476594..1476612 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-10" upshifts 1476598 /Source="Nicolas_upshifts" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="upshifts" CDS 1476653..1479325 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12161109, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12161109, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="P-type calcium transport ATPase (sporulation)" /protein_id="NP_389448.1" /db_xref="EnsemblGenomes-Gn:BSU15650" /db_xref="EnsemblGenomes-Tr:CAB13439" /db_xref="GOA:O34431" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR004014" /db_xref="InterPro:IPR005782" /db_xref="InterPro:IPR006068" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13384" /db_xref="UniProtKB/Swiss-Prot:O34431" /translation="MKFHEMGQTDLLEATNTSMKQGLTEKEVKKRLDKHGPNELQEGK KTSALLLFFAQFKDFMVLVLLAATLISGFLGEYVDAVAIIAIVFVNGILGFFQERRAE QSLQALKELSTPHVMALREGSWTKIPSKELVPGDIVKFTSGDRIGADVRIVEARSLEI EESALTGESIPVVKHADKLKKPDVSLGDITNMAFMGTIVTRGSGVGVVVGTGMNTAMG KIADMLESAGTLSTPLQRRLEQLGKILIVVALLLTVLVVAVGVIQGHDLYSMFLAGVS LAVAAIPEGLPAIVTVALSLGVQRMIKQKSIVRKLPAVETLGCASIICSDKTGTMTQN KMTVTHVWSGGKTWRVAGAGYEPKGSFTLNEKEISVNEHKPLQQMLLFGALCNNSNIE KRDGEYVLDGDPTEGALLTAARKGGFSKEFVESNYRVIEEFPFDSARKMMTVIVENQD RKRYIITKGAPDVLMQRSSRIYYDGSAALFSNERKAETEAVLRHLASQALRTIAVAYR PIKAGETPSMEQAEKDLTMLGLSGIIDPPRPEVRQAIKECREAGIKTVMITGDHVETA KAIAKDLRLLPKSGKIMDGKMLNELSQEELSHVVEDVYVFARVSPEHKLKIVKAYQEN GHIVAMTGDGVNDAPAIKQADIGVSMGITGTDVAKEASSLVLVDDNFATIKSAIKEGR NIYENIRKFIRYLLASNVGEILVMLFAMLLALPLPLVPIQILWVNLVTDGLPAMALGM DQPEGDVMKRKPRHPKEGVFARKLGWKVVSRGFLIGVATILAFIIVYHRNPENLAYAQ TIAFATLVLAQLIHVFDCRSETSVFSRNPFQNLYLIGAVLSSILLMLVVIYYPPLQPI FHTVAITPGDWMLVIGMSAIPTFLLAGSLLTRKK*" /label="tcaB CDS" gene 1476653..1479325 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /label="tcaB gene" promotor_-10 complement(1478058..1478077) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1478069) /Source="Nicolas_upshifts" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1478092..1478099) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1479331..1479350 /Source="Nicolas_upshift_promotors" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1479334..1479407 /Source="Nicolas_S_feature" /locus_tag="new_1640646_1640719" /HighExp="LPhT, LBGstat, T3.0H, H2O2, T3.30H, Salt, B60, Lbexp, UNK1, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.994, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S571" upshifts 1479334 /Source="Nicolas_upshifts" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1479408..1480283 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389449.1" /db_xref="EnsemblGenomes-Gn:BSU15660" /db_xref="EnsemblGenomes-Tr:CAB13440" /db_xref="InterPro:IPR005229" /db_xref="InterPro:IPR013527" /db_xref="InterPro:IPR013551" /db_xref="SubtiList:BG13385" /db_xref="UniProtKB/Swiss-Prot:O34441" /translation="MIRSMTGFGSASKTQDDLSVSVELKSVNYRFKEVNARLPRPLLY FEDKLKQTILQHIQRGRIELFVSVDSDMLVEKRLEIDWPLLDEFVAAARDMKKRYQLS AEPDVMDFFKLDHVVQVHEEQTQNDKLEALIIDAAEEAVKGLCEMREKEGLLLAKDCL MHIDQLEELVRETELLAADVVSRYRERLYARIKEWTEDVLDESRLVTECAIFADRSDI TEEITRLKSHFAQFRDILASGGAVGRKLDFLVQELNREANTIGSKANDHQITKLVVEM KSSIEKIKEQVQNIE*" /label="yloC CDS" gene 1479408..1480283 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /label="yloC gene" CDS 1480360..1480629 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116, 23396918, 23646920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116, 23396918, 23646920; Product type r: regulator" /codon_start=1 /transl_table=11 /product="essential sporulation DNA binding protein; regulator of biofilm formation" /protein_id="NP_570902.1" /db_xref="EnsemblGenomes-Gn:BSU15670" /db_xref="EnsemblGenomes-Tr:CAE01452" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG14185" /db_xref="UniProtKB/Swiss-Prot:Q7WY72" /translation="MTIKLINIGFGNIISANRMISIVSPESAPIKRMIQDARDRGMLI DATYGRRTRAVVVMDSDHIILSAVQPETVAHRLSVKEEIMDEGQG*" /label="remA CDS" gene 1480360..1480629 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /label="remA gene" misc_feature complement(1480440..1480444) /Source="Nicolas_upshift_promotors" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1480445) /Source="Nicolas_upshifts" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1480637..1481251 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /EC_number="2.7.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17012781, 24722991" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17012781, 24722991; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanylate kinase" /protein_id="NP_389450.2" /db_xref="EnsemblGenomes-Gn:BSU15680" /db_xref="EnsemblGenomes-Tr:CAB13441" /db_xref="GOA:O34328" /db_xref="InterPro:IPR008144" /db_xref="InterPro:IPR008145" /db_xref="InterPro:IPR017665" /db_xref="InterPro:IPR020590" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13386" /db_xref="UniProtKB/Swiss-Prot:O34328" /translation="MKERGLLIVLSGPSGVGKGTVRQAIFSQEDTKFEYSISVTTRSP REGEVNGVDYFFKTRDEFEQMIADNKLLEWAEYVGNYYGTPVDYVEQTLQDGKDVFLE IEVQGALQVRNAFPEGLFIFLAPPSLSELKNRIVTRGTETDALIENRMKAAKAEIEMM DAYDYVVENDNVETACDKIKAIVLAEHLKRERVAPRYKKMLEVE*" /label="gmk CDS" gene 1480637..1481251 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /label="gmk gene" CDS 1481255..1481458 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12089032, 16159791, 17233676, 24476911, 25878038; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega subunit of RNA polymerase" /protein_id="NP_389451.1" /db_xref="EnsemblGenomes-Gn:BSU15690" /db_xref="EnsemblGenomes-Tr:CAB13442" /db_xref="GOA:O35011" /db_xref="InterPro:IPR003716" /db_xref="InterPro:IPR006110" /db_xref="InterPro:IPR012293" /db_xref="InterPro:IPR036161" /db_xref="SubtiList:BG13387" /db_xref="UniProtKB/Swiss-Prot:O35011" /translation="MLDPSIDSLMNKLDSKYTLVTVSARRAREMQIKKDQMIEHTISH KYVGKALEEIDAGLLSFEKEDRE*" /label="rpoZ CDS" gene 1481255..1481458 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /label="rpoZ gene" downshifts 1481447 /Source="Nicolas_upshifts" /id="D877" /incds=0 /nref=118 /ntot=257 /MaxReadThrough="5.65143" /MaxDrop="4.7291" /score="-8.13961715" /energy="-7.7" /TU="U1293,U1295" /idTUdmin="U1293" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS 1481539..1482759 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /EC_number="4.1.1.36" /EC_number="6.3.2.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11278255, 11358972, 12140293, 14686929, 15530362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coenzyme A biosynthesis bifunctional protein CoaBC; phosphopantothenoylcysteine synthetase/decarboxylase" /protein_id="NP_389452.1" /db_xref="EnsemblGenomes-Gn:BSU15700" /db_xref="EnsemblGenomes-Tr:CAB13443" /db_xref="GOA:O35033" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR005252" /db_xref="InterPro:IPR007085" /db_xref="InterPro:IPR035929" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG13388" /db_xref="UniProtKB/Swiss-Prot:O35033" /translation="MLNNRNVLLCVSGGIAVYKACALTSKLVQAGANVKVIMTESACR FVSPLTFQALSRHEVYTDTFKEQNPSVISHIDAADWADLIIVAPATANVIGKLANGIA DDMLTTTLLAATAPVWIAPAMNVHMYDHPAVKRNISVLYQDGYCFIEPSEGYLACGYV GKGRLEEPENIVKLAEKHFAEETSAPLEGKHVVITAGPTREAIDPVRFFTNKSTGKMG YALAEAAVQLGARVILISGPVSLDQPKGLAEFIPVQSAADMREAVLSVYDASDIVIKT AAVADFTPKTVFDHKMKKQDGGMTLELKRTVDILKELGEKKKEQILVGFAAETQDIEH YARKKLAAKNLDLIVANDVKANGAGFGADTNIVTIFFKDGHKRELPIMSKLDVSFEIL QEIAALSKQTGERS*" /label="coaBC CDS" gene 1481539..1482759 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /label="coaBC gene" S_feature complement(1482598..1483173) /Source="Nicolas_S_feature" /locus_tag="new_1643910_1644485_c" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, B60, LPhT, HiTm, Heat" /AntisenseName="priA" /AntisenseCor="-5.1213364637925501E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S572" CDS 1482756..1485173 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10572298, 11917020, 12682299, 21170359, 22720735, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572298, 11917020, 12682299, 21170359, 22720735, 28527403; Product type f : factor" /codon_start=1 /transl_table=11 /product="primosomal replication factor Y (primosomal protein N')" /protein_id="NP_389453.1" /db_xref="EnsemblGenomes-Gn:BSU15710" /db_xref="EnsemblGenomes-Tr:CAB13444" /db_xref="GOA:P94461" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005259" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11963" /db_xref="UniProtKB/Swiss-Prot:P94461" /translation="MNFAEVIVDVSTKNIDRPFDYKIPDHLKGMIKTGMRVIVPFGPR KIQGFVTAVKEASDLSGKSVKEVEDLLDLTPVLTEELMILSSWLSDKTLSFKITALQA MLPAALKAKYEKELKIAHGADLPPQVERLFSETKTLLYSDIPDHETLKLIQRHVQKGD IDVTYKVAQKTNKKMVRHIQANASKEELAKQAEGLSRQAAKQQAILHFLISEPEGVKI PAAELCKKTDTSSATIKTLIQKGLLKESYEEVYRDPYQDKMFKKTEPLPLTDEQRAAF EPIRETLDSDEHKVFLLHGVTGSGKTEIYLQSIEKVLAKGKEAIVLVPEISLTPQMVN RFKGRFGSQVAVMHSGLSTGEKYDEWRKIHRKEVRLVVGARSAIFAPFENLGMIIIDE EHESSYKQEEMPRYHAKEVAIKRAEHHSCPVVLGSATPTLESYARAQKGVYELLSLKH RVNHRVMPEVSLVDMREELRNGNRSMFSVELMEKLEETIAKGEQAVLFLNKRGYSSFV MCRDCGYVPQCPHCDISMTYHRYGQRLKCHYCGHEEPVPHTCPECASEHIRFFGTGTQ RVEEELTKVLPSARVIRMDVDTTSRKGAHEKLLSAFGEGKADILLGTQMIAKGLDFPN VTLVGVLSADTTLHIPDFRSAEKTFQLLTQVSGRAGRHEKPGHVIIQTYTPSHYSIQL TKTHDYETFYQHEMAHRREQSYPPYYYLALVTVSHEEVAKAAVTAEKIAHFLKANCGA DTKILGPSASPIARIKDRYRYQCVIKYKQETQLSALLKKILEHYKREIEQKHVMISID MNPYMMM*" /label="priA CDS" gene 1482756..1485173 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /label="priA gene" promotor_-10 complement(1483169..1483187) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1483173) /Source="Nicolas_upshifts" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1483201..1483207) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1485024..1485028 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1485044..1485063 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1485055 /Source="Nicolas_upshifts" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1485200..1485682 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /EC_number="3.5.1.88" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11429456, 16014871, 16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16014871, 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide deformylase" /protein_id="NP_389454.1" /db_xref="EnsemblGenomes-Gn:BSU15720" /db_xref="EnsemblGenomes-Tr:CAB13445" /db_xref="GOA:P94462" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11933" /db_xref="UniProtKB/Swiss-Prot:P94462" /translation="MAVKKVVTHPAEVLETPAETVTVFDKKLKKLLDDMYDTMLEMDG VGLAAPQIGILKRAAVVEIGDDRGRIDLVNPEILEKSGEQTGIEGCLSFPNVYGDVTR ADYVKVRAFNRQGKPFILEARGFLARAVQHEMDHLDGVLFTSKISKYYTEDELADMEG *" /label="defA CDS" gene 1485200..1485682 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /label="defA gene" CDS 1485687..1486640 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /EC_number="2.1.2.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA formyltransferase" /protein_id="NP_389455.1" /db_xref="EnsemblGenomes-Gn:BSU15730" /db_xref="EnsemblGenomes-Tr:CAB13446" /db_xref="GOA:P94463" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR005793" /db_xref="InterPro:IPR005794" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036477" /db_xref="InterPro:IPR037022" /db_xref="SubtiList:BG11937" /db_xref="UniProtKB/Swiss-Prot:P94463" /translation="MTRIVFMGTPDFSVPVLRTLIEDGYEVVGVVTQPDRPKGRKKVL TPPPVKEEALRHGIPVLQPEKVRLTEEIEKVLALKPDLIVTAAFGQILPKELLDSPKY GCINVHASLLPELRGGAPIHYSILQGKKKTGITIMYMVEKLDAGDMISKVEVDIEETD NVGTLHDKLSVAGAKLLSETVPNVIAGSISPEKQDEEKATYAPNIKREQELLDWSRTG EELYNQIRGLNPWPVAYTTLNGQNLKIWASKKIAAPTTAEPGTVVAVEKEGIIVATGN ETALLLTELQPAGKKRMKGEDFVRGAHVEAGDVLGVNNEKN*" /label="fmt CDS" gene 1485687..1486640 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /label="fmt gene" CDS 1486627..1487970 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /EC_number="2.1.1.176" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14656444, 23729652, 27698115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA-binding Sun protein; 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent" /protein_id="NP_389456.1" /db_xref="EnsemblGenomes-Gn:BSU15740" /db_xref="EnsemblGenomes-Tr:CAB13447" /db_xref="GOA:P94464" /db_xref="InterPro:IPR001678" /db_xref="InterPro:IPR004573" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR018314" /db_xref="InterPro:IPR023267" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG12253" /db_xref="UniProtKB/Swiss-Prot:P94464" /translation="MKKTSVRDIALEALIKLEQNQAYSNLLLKSVIKSNELSDQNRGL LTELVYGTLQNKIALDYMLKPFINKPQKVKPWVIQLLRLSLYQMEYLEKIPDRAAIHE AVEIAKIRGHKGIASFVNGVLRSIQREGVPSFDAIEDPVRRLATETSHPEWLVKEWAD AYGFEAAEKICRIHLIPPKQTLRVNQMKADRAELLDQMAAEGIEVEKGDLAEDAVKLL KGTIAGTHFFQNGEVSIQDESSMLVARALDPKSDETVLDACAAPGGKSAHIAELMKNK GSVTSLDLHKHKVKLIKEAADRLGLTIIHAETMDARKAGETFENEQFDRILVDAPCSG FGVIRRKPDMKYTKKPDDSARLAEIQLSILREIAPLVKKGGTLVYSTCTMDRTENDEV IHAFIQEHPDFEPDLSLEKRLPEKVRPFVRDGRLQILPHYFGTDGFFICSMRKKG*" /label="rsmB CDS" gene 1486627..1487970 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /label="rsmB gene" CDS 1487974..1489065 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /EC_number="2.1.1.192" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8973346, 18307109, 20184321, 21368151, 22891362, 27081063, 27902775; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2A2503 methyltransferase and tRNA A37 C2 methyltransferase" /protein_id="NP_389457.1" /db_xref="EnsemblGenomes-Gn:BSU15750" /db_xref="EnsemblGenomes-Tr:CAB13448" /db_xref="GOA:O34617" /db_xref="InterPro:IPR004383" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR027492" /db_xref="SubtiList:BG13389" /db_xref="UniProtKB/Swiss-Prot:O34617" /translation="MAELNKTKVRKELRTERPSIYSFELDEIKQWLTDNGEKPFRAAQ IFEWLYEKRVSSFEDMTNLSKDLREKLNTRFVLTTLKTAVKQTSQDGTMKFLFELHDG YTIETVLMRHEYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVKVQKAL DETDERVSSVVIMGIGEPFDNFNEMLAFLKIINHDKGLNIGARHITVSTSGIIPKIYE FADQQMQINFAISLHAPNTEIRSRLMPINRAYKLPDLMEAVKYYINKTGRRISFEYGL FGGVNDQVEHAEELADLLEGVKCHVNLIPVNYVPERDYVRTPRDQIFAFEKTLKSRGV NVTIRREQGHDIDAACGQLRAKERQDETR*" /label="rlmN CDS" gene 1487974..1489065 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /label="rlmN gene" CDS 1489072..1489836 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /EC_number="3.1.3.16" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 17693724, 22720735, 24390483, 25012659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 17693724, 22720735, 24390483, 25012659; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="multitarget phosphorylated protein phosphatase" /protein_id="NP_389458.1" /db_xref="EnsemblGenomes-Gn:BSU15760" /db_xref="EnsemblGenomes-Tr:CAB13449" /db_xref="GOA:O34779" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR015655" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG13390" /db_xref="UniProtKB/Swiss-Prot:O34779" /translation="MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAG DVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQILSVNSKIYDHAQAHEECQGMGT TIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHP RKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQE KVNLLVDKANQNGGEDNITAVLLELALQVEEGEDQC*" /label="prpC CDS" gene 1489072..1489836 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /label="prpC gene" downshifts 1489125 /Source="Nicolas_upshifts" /id="D878" /incds=0 /nref=5 /ntot=126 /MaxReadThrough="6.12318" /MaxDrop="3.8594" /score="-7.80200272" /energy="-10" /TU="U1295,U1298" /idTUdmin="U1300" /TUdmin="-4708" /isTUend="FALSE" /label="downshifts" CDS 1489830..1491776 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /EC_number="2.7.11.1" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 18984160, 24390483, 25845974, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 18984160, 24390483, 25845974, 26102633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine/threonine kinase" /protein_id="NP_389459.1" /db_xref="EnsemblGenomes-Gn:BSU15770" /db_xref="EnsemblGenomes-Tr:CAB13450" /db_xref="GOA:O34507" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR008271" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13391" /db_xref="UniProtKB/Swiss-Prot:O34507" /translation="MLIGKRISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRF DYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITA NGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALS STTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESAVSI ALKHLQAETPSAKRWNPSVPQSVENIILKATAKDPFHRYETAEDMEADIKTAFDADRL NEKRFTIQEDEEMTKAIPIIKDEELAKAAGEKEAEVTTAQENKTKKNGKRKKWPWVLL TICLVFITAGILAVTVFPSLFMPKDVKIPDVSGMEYEKAAGLLEKEGLQVDSEVLEIS DEKIEEGLMVKTDPKADTTVKEGATVTLYKSTGKAKTEIGDVTGQTVDQAKKALKDQG FNHVTVNEVNDEKNAGTVIDQNPSAGTELVPSEDQVKLTVSIGPEDITLRDLKTYSKE AASGYLEDNGLKLVEKEAYSDDVPEGQVVKQKPAAGTAVKPGNEVEVTFSLGPEKKPA KTVKEKVKIPYEPENEGDELQVQIAVDDADHSISDTYEEFKIKEPTERTIELKIEPGQ KGYYQVMVNNKVVSYKTIEYPKDE*" /label="prkC CDS" gene 1489830..1491776 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /label="prkC gene" promotor_-35 1491685..1491691 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1491705..1491723 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1491721 /Source="Nicolas_upshifts" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1491791..1492687 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome biogenesis" /protein_id="NP_389460.1" /db_xref="EnsemblGenomes-Gn:BSU15780" /db_xref="EnsemblGenomes-Tr:CAB13451" /db_xref="GOA:O34530" /db_xref="InterPro:IPR004881" /db_xref="InterPro:IPR010914" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="InterPro:IPR031944" /db_xref="PDB:1T9H" /db_xref="SubtiList:BG13392" /db_xref="UniProtKB/Swiss-Prot:O34530" /translation="MPEGKIIKALSGFYYVLDESEDSDKVIQCRGRGIFRKNKITPLV GDYVVYQAENDKEGYLMEIKERTNELIRPPICNVDQAVLVFSAVQPSFSTALLDRFLV LVEANDIQPIICITKMDLIEDQDTEDTIQAYAEDYRNIGYDVYLTSSKDQDSLADIIP HFQDKTTVFAGQSGVGKSSLLNAISPELGLRTNEISEHLGRGKHTTRHVELIHTSGGL VADTPGFSSLEFTDIEEEELGYTFPDIREKSSSCKFRGCLHLKEPKCAVKQAVEDGEL KQYRYDHYVEFMTEIKDRKPRY*" /label="rsgA CDS" gene 1491791..1492687 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /label="rsgA gene" CDS 1492692..1493345 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /EC_number="5.1.3.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 973353, 15755726, 16489742, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribulose-5-phosphate 3-epimerase" /protein_id="NP_389461.1" /db_xref="EnsemblGenomes-Gn:BSU15790" /db_xref="EnsemblGenomes-Tr:CAB13452" /db_xref="GOA:O34557" /db_xref="InterPro:IPR000056" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR026019" /db_xref="SubtiList:BG13393" /db_xref="UniProtKB/Swiss-Prot:O34557" /translation="MIKVAPSILSADFAALGNEIKDVEKGGADCIHIDVMDGHFVPNI TIGPLIVEAVRPVTDLPLDVHLMIEEPDRYIPAFAKAGADILSVHAEACPHLHRTIQL IKEQGVKAGVVLNPHTPVQVIEHVFDDLDLVLLMTVNPGFGGQKFIHSVLPKIKEVKR MADEKGKKDLLIEVDGGVNKETAPLVIEAGANLLVAGSAVYGQSDRKKAISEIRGSK* " /label="rpe CDS" gene 1492692..1493345 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /label="rpe gene" promotor_-35 1493343..1493352 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-35" promotor_-10 1493366..1493385 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-10" upshifts 1493371 /Source="Nicolas_upshifts" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="upshifts" CDS 1493418..1494062 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /EC_number="2.7.6.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14567704, 15150256, 16291685, 19490098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine pyrophosphokinase" /protein_id="NP_389462.1" /db_xref="EnsemblGenomes-Gn:BSU15800" /db_xref="EnsemblGenomes-Tr:CAB13453" /db_xref="GOA:O34664" /db_xref="InterPro:IPR006282" /db_xref="InterPro:IPR007371" /db_xref="InterPro:IPR007373" /db_xref="InterPro:IPR036371" /db_xref="InterPro:IPR036759" /db_xref="PDB:3LM8" /db_xref="SubtiList:BG13394" /db_xref="UniProtKB/Swiss-Prot:O34664" /translation="MKTINIVAGGPKNLIPDLTGYTDEHTLWIGVDKGTVTLLDAGII PVEAFGDFDSITEQERRRIEKAAPALHVYQAEKDQTDLDLALDWALEKQPDIIQIFGI TGGRADHFLGNIQLLYKGVKTNIKIRLIDKQNHIQMFPPGEYDIEKDENKRYISFIPF SEDIHELTLTGFKYPLNNCHITLGSTLCISNELIHSRGTFSFAKGILIMIRSTD*" /label="thiN CDS" gene 1493418..1494062 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /label="thiN gene" promotor_-35 1493823..1493829 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-35" upshifts 1493840 /Source="Nicolas_upshifts" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="upshifts" promotor_-10 1493844..1493862 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-10" promotor_-35 1493953..1493958 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1493974..1493992 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1493987 /Source="Nicolas_upshifts" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1494063..1494133 /Source="Nicolas_S_feature" /locus_tag="new_1655375_1655445" /HighExp="S4, S5, S7, S8, S6, S3, B36, G/S, B60, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigB, SigA, SigA" /TUshortPSig="0.977, 0.548, 0.973, 1, 0.994" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S573" CDS 1494134..1494214 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for normal spore cortex and coatsynthesis (stage V sporulation)" /protein_id="NP_389463.1" /db_xref="EnsemblGenomes-Gn:BSU15810" /db_xref="EnsemblGenomes-Tr:CAB13454" /db_xref="GOA:P37817" /db_xref="InterPro:IPR012609" /db_xref="PDB:2MVH" /db_xref="PDB:2MVJ" /db_xref="SubtiList:BG10776" /db_xref="UniProtKB/Swiss-Prot:P37817" /translation="MKFYTIKLPKFLGGIVRAMLGSFRKD*" /label="spoVM CDS" gene 1494134..1494214 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /label="spoVM gene" downshifts 1494229 /Source="Nicolas_upshifts" /id="D879" /incds=0 /nref=178 /ntot=258 /MaxReadThrough="4.05442" /MaxDrop="7.745" /score="7.47691609" /energy="-16.9" /TU="U1301,U1302" /idTUdmin="U1295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1494274..1494646 /Source="Nicolas_S_feature" /locus_tag="new_1655586_1655958" /HighExp="S4, S5, T5.0H, S3, S6, S8, S7, T4.0H, LoTm, T3.30H" /AntisenseName="rpmB" /AntisenseCor="-0.40376097579549802" /AntisenseRegPval="-11.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.977, 0.548" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S574" CDS complement(1494287..1494475) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8722036; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L28" /protein_id="NP_389464.1" /db_xref="EnsemblGenomes-Gn:BSU15820" /db_xref="EnsemblGenomes-Tr:CAB13455" /db_xref="GOA:P37807" /db_xref="InterPro:IPR001383" /db_xref="InterPro:IPR026569" /db_xref="InterPro:IPR034704" /db_xref="InterPro:IPR037147" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10777" /db_xref="UniProtKB/Swiss-Prot:P37807" /translation="MARKCVITGKKTTAGNNRSHAMNASKRTWGANLQKVRILVNGKP KKVYVSARALKSGKVERV*" /label="rpmB CDS" gene complement(1494287..1494475) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /label="rpmB gene" downshifts complement(1494303) /Source="Nicolas_upshifts" /id="D880" /incds=0 /nref=216 /ntot=298 /MaxReadThrough="2.59598" /MaxDrop="7.48719" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" downshifts complement(1494349) /Source="Nicolas_upshifts" /id="D881" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="7.6779" /MaxDrop="3.1786" /score="15.2403969" /energy="-14.3" /TU="U1303" /idTUdmin="U1303" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(1494476..1494568) /Source="Nicolas_S_feature" /locus_tag="new_1655788_1655880_c" /HighExp="HPh, LPh, HiOs, LBGexp, aero, G180, GM 15, dia0, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S575" promotor_-10 complement(1494550..1494569) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1494568) /Source="Nicolas_upshifts" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1494585..1494588) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1494619..1494626 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1494641..1494659 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1494648 /Source="Nicolas_upshifts" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" promotor_-35 1494687..1494690 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1494705..1494724 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1494713 /Source="Nicolas_upshifts" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" CDS 1494752..1495114 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 17114254, 24178028, 28579978; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor involved in malonyl-CoA synthesis" /protein_id="NP_389465.1" /db_xref="EnsemblGenomes-Gn:BSU15830" /db_xref="EnsemblGenomes-Tr:CAB13456" /db_xref="InterPro:IPR005531" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG13395" /db_xref="UniProtKB/Swiss-Prot:O34318" /translation="MSIELRTKYGQIDISNEVIAMVAGGAAVDCYGIVGMASKNQIKD GLTEILRKENFSRGVQVRQEGEQIHIDMYIIVSYGTKISEVAHNVQTKVKYTVNQTIG LAVDSVNIYVQGVRVTNP*" /label="yloU CDS" gene 1494752..1495114 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /label="yloU gene" downshifts complement(1494965) /Source="Nicolas_upshifts" /id="D882" /incds=1 /nref=1 /ntot=143 /MaxReadThrough="1.75412" /MaxDrop="2.71497" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1495130..1496791 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16647083, 22333191, 22517742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme structurally related to dihydroxyacetone/glyceraldehyde kinase" /protein_id="NP_389466.1" /db_xref="EnsemblGenomes-Gn:BSU15840" /db_xref="EnsemblGenomes-Tr:CAB13457" /db_xref="GOA:O34751" /db_xref="InterPro:IPR004007" /db_xref="InterPro:IPR019986" /db_xref="InterPro:IPR033470" /db_xref="InterPro:IPR036117" /db_xref="SubtiList:BG13396" /db_xref="UniProtKB/Swiss-Prot:O34751" /translation="MSIRTLDGRTFAEMILAGAQNLSQNASAVDALNVFPVPDGDTGT NMNLSMTSGAREVEQMDTDDIGKVGSALSKGLLMGARGNSGVILSQLFRGFSKNIETK KEINALEFAAALQAGVDMAYKAVMKPVEGTILTVAKDAAKKAMILAEKETDITALMTA VTEEAEASLNRTPELLPVLKEVGVVDSGGKGLLCVYEGFLASLKGETVPQKAVLPSLD DMVSAEHHKSAQSMMNTEDIEFGFCTEVMVRLDQTKREFDEGTFRQDLSQFGDSLLVI ADESLAKVHIHAEEPGNVLNYAQHYGELIKIKIENMREQHTSIISQESKPADNETPPA KQPYGIVTVAMGEGIADLFKSIGASVVIEGGQTMNPSTEDIVDAVKSVNADTVFILPN NSNIIMAANQAASVVDEQVFVIPAKTVPQGMSALLAFNPDQEAEANEANMLSAIQQVK SGQVTFSVRDTHIDGKDIKKGDFMGILNGTIIGTSENQLSAAKMLLSEMIGEDDEIVT ILYGEDASQEEAEQLEAFLSEKYEEIEVEIHNGKQPLYSYIVSAE*" /label="yloV CDS" gene 1495130..1496791 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /label="yloV gene" S_feature 1496792..1496881 /Source="Nicolas_S_feature" /locus_tag="new_1658104_1658193" /HighExp="G135, G180, G150, LBGexp, Oxctl, Paraq, dia0, LPh, Lbexp, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37023200000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.991, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S576" promotor_-35 1496854..1496861 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-35" promotor_-10 1496875..1496894 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-10" upshifts 1496883 /Source="Nicolas_upshifts" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="upshifts" CDS 1496930..1497592 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8385012, 9244285, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385012, 9244285, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (beta chain)" /protein_id="NP_389467.1" /db_xref="EnsemblGenomes-Gn:BSU15850" /db_xref="EnsemblGenomes-Tr:CAB13458" /db_xref="GOA:O34635" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004643" /db_xref="InterPro:IPR005131" /db_xref="InterPro:IPR029009" /db_xref="SubtiList:BG13397" /db_xref="UniProtKB/Swiss-Prot:O34635" /translation="MKYRSVFDIIGPVMIGPSSSHTAGAARIGRVARSLFGREPERII VSFYGSFAETYKGHGTDVAIIGGLLDFDTFDERIKTAIQIAEAKGIDIEFRVEDAVPV HPNTAKITISDEKGELELTGISIGGGKIEITELNGFELRLSGNHPAILVVHNDKFGTI AGVANVLAKFSINVGHMEVARKDIGQLALMTIEVDQNIDDHILDELSKLPNIIQVTKI AD*" /label="sdaAB CDS" gene 1496930..1497592 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /label="sdaAB gene" CDS 1497618..1498520 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2504697, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2504697, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (alpha chain)" /protein_id="NP_389468.1" /db_xref="EnsemblGenomes-Gn:BSU15860" /db_xref="EnsemblGenomes-Tr:CAB13459" /db_xref="GOA:O34607" /db_xref="InterPro:IPR004642" /db_xref="InterPro:IPR005130" /db_xref="SubtiList:BG13398" /db_xref="UniProtKB/Swiss-Prot:O34607" /translation="MFRNVKELIEITKEKQILISDVMIAQEMEVTEKTKEDIFQQMDH NLSVMEAAVQKGLEGVTSQTGLTGGDAVKLQAYIRSGKSLSGPLILDAVSKAVATNEV NAAMGTICATPTAGSAGVVPGTLFAVKEKLNPTREQMIRFLFTAGAFGFVVANNASIS GAAGGCQAEVGSASGMAAAAIVEMAGGTPEQSAEAMAITLKNMLGLVCDPVAGLVEVP CVKRNAMGASNAMIAADMALAGITSRIPCDEVIDAMYKIGQTMPTALRETGQGGLAAT PTGRELEKKIFGGALGSRETTSAN*" /label="sdaAA CDS" gene 1497618..1498520 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /label="sdaAA gene" CDS 1498498..1500546 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branch migrating ATP-dependent DNA helicase involved in DNA recombination and repair" /protein_id="NP_389469.1" /db_xref="EnsemblGenomes-Gn:BSU15870" /db_xref="EnsemblGenomes-Tr:CAB13460" /db_xref="GOA:O34942" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR004609" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033454" /db_xref="SubtiList:BG13399" /db_xref="UniProtKB/Swiss-Prot:O34942" /translation="MKQHQQTSIANIKGIGPETEKTLNELGIYDISDLLNYFPYRYDD YELRDLEEVKHDERVTVEGKVHSEPSLTYYGKKRNRLTFRLLVGHYLITAVCFNRPYL KKKLSLGSVVTVSGKWDKHRQTISVQELKNGPHQEDKSIEPVYSVKENVTVKMMRRFI QQALTQYADSLPDPLPEKLRKSYKLPDYYQALKAMHQPETREALKLARRRFVYEEFLL FQLKMQAFRKAEREQTQGIRQRFSNEELMRFIKSLPFPLTNAQSRVLREITADMSSPY RMNRLLQGDVGSGKTAVAAIALYAAILSGYQGALMVPTEILAEQHADSLVSLFEKWDV SVALLTSSVKGKRRKELLERLAAGEIDILVGTHALIQDEVEFKALSLVITDEQHRFGV EQRKKLRNKGQDPDVLFMTATPIPRTLAITVFGEMDVSVIDEMPAGRKRIETYWVKHD MLDRILAFVEKELKQGRQAYIICPLIEESDKLDVQNAIDVYNMLSDIFRGKWNVGLMH GKLHSDEKDQVMREFSANHCQILVSTTVVEVGVNVPNATIMVIYDADRFGLSQLHQLR GRVGRGEHQSFCILMADPKSETGKERMRIMSETNDGFELSEKDLELRGPGDFFGKKQS GMPEFKVADMVHDYRALETARQDAANLVASDAFWKEPEYAVLRDELLKSGVMDGEKLS *" /label="recG CDS" gene 1498498..1500546 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /label="recG gene" promotor_-35 1500582..1500589 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1500604..1500623 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1500610 /Source="Nicolas_upshifts" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1500655..1501221 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12737802, 17962296, 20201588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12737802, 17962296, 20201588, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription factor controlling fatty acid and phospholipid metabolism (FapR-malonyl-Coa)" /protein_id="NP_389470.1" /db_xref="EnsemblGenomes-Gn:BSU15880" /db_xref="EnsemblGenomes-Tr:CAB13461" /db_xref="GOA:O34835" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR017275" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="PDB:2F3X" /db_xref="PDB:2F41" /db_xref="SubtiList:BG13400" /db_xref="UniProtKB/Swiss-Prot:O34835" /translation="MRRNKRERQELLQQTIQATPFITDEELAGKFGVSIQTIRLDRLE LSIPELRERIKNVAEKTLEDEVKSLSLDEVIGEIIDLELDDQAISILEIKQEHVFSRN QIARGHHLFAQANSLAVAVIDDELALTASADIRFTRQVKQGERVVAKAKVTAVEKEKG RTVVEVNSYVGEEIVFSGRFDMYRSKHS*" /label="fapR CDS" gene 1500655..1501221 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /label="fapR gene" CDS 1501235..1502236 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphate:acyl-ACP acyltransferase" /protein_id="NP_389471.1" /db_xref="EnsemblGenomes-Gn:BSU15890" /db_xref="EnsemblGenomes-Tr:CAB13462" /db_xref="GOA:P71018" /db_xref="InterPro:IPR003664" /db_xref="InterPro:IPR012281" /db_xref="PDB:1VI1" /db_xref="SubtiList:BG11843" /db_xref="UniProtKB/Swiss-Prot:P71018" /translation="MRIAVDAMGGDHAPKAVIDGVIKGIEAFDDLHITLVGDKTTIES HLTTTSDRITVLHADEVIEPTDEPVRAVRRKKNSSMVLMAQEVAENRADACISAGNTG ALMTAGLFIVGRIKGIDRPALAPTLPTVSGDGFLLLDVGANVDAKPEHLVQYAIMGSV YSQQVRGVTSPRVGLLNVGTEDKKGNELTKQTFQILKETANINFIGNVEARDLLDDVA DVVVTDGFTGNVTLKTLEGSALSIFKMMRDVMTSTLTSKLAAAVLKPKLKEMKMKMEY SNYGGASLFGLKAPVIKAHGSSDSNAVFHAIRQAREMVSQNVAALIQEEVKEEKTDE* " /label="plsX CDS" gene 1501235..1502236 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /label="plsX gene" CDS 1502255..1503208 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /EC_number="2.3.1.39" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586097, 19850612" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586097, 19850612; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malonyl CoA:acyl carrier protein transacylase" /protein_id="NP_389472.1" /db_xref="EnsemblGenomes-Gn:BSU15900" /db_xref="EnsemblGenomes-Tr:CAB13463" /db_xref="GOA:P71019" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR024925" /db_xref="SubtiList:BG11836" /db_xref="UniProtKB/Swiss-Prot:P71019" /translation="MSKIAFLFPGQGSQFIGMGKELYEQVPAAKRLFDEADETLETKL SSLIFEGDAEELTLTYNAQPALLTTSIAVLEKFKESGITPDFTAGHSLGEYSALVAAG ALSFKDAVYTVRKRGEFMNEAVPAGEGAMAAILGMDAEALKQVTDKVTEEGNLVQLAN LNCPGQIVISGTAKGVELASELAKENGAKRAIPLEVSGPFHSELMKPAAEKLKEVLDA CDIKDADVPVISNVSADVMTEKADIKEKLIEQLYSPVRFEESINKLIAEGVTTFIEIG PGKVLSGLVKKVNRRLKTIAVSDPETIELAIQTLKEENDNA*" /label="fabD CDS" gene 1502255..1503208 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /label="fabD gene" CDS 1503201..1503941 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /EC_number="1.1.1.100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12655455, 12682299, 19850612, 28126742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12655455, 12682299, 19850612, 28126742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein reductase" /protein_id="NP_389473.1" /db_xref="EnsemblGenomes-Gn:BSU15910" /db_xref="EnsemblGenomes-Tr:CAB13464" /db_xref="GOA:P51831" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011284" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11535" /db_xref="UniProtKB/Swiss-Prot:P51831" /translation="MLNDKTAIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANE VVDEIKSMGRKAIAVKADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMK EDEWDDVININLKGVFNCTKAVTRQMMKQRSGRIINVSSIVGVSGNPGQANYVAAKAG VIGLTKSSAKELASRNITVNAIAPGFISTDMTDKLAKDVQDEMLKQIPLARFGEPSDV SSVVTFLASEGARYMTGQTLHIDGGMVM*" /label="fabG CDS" gene 1503201..1503941 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /label="fabG gene" promotor_-35 1503972..1503976 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1503992..1504011 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1503997 /Source="Nicolas_upshifts" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1504025..1504258 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 19850612, 27467752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 19850612, 27467752; Product type c: carrier" /codon_start=1 /transl_table=11 /product="acyl carrier protein" /protein_id="NP_389474.1" /db_xref="EnsemblGenomes-Gn:BSU15920" /db_xref="EnsemblGenomes-Tr:CAB13465" /db_xref="GOA:P80643" /db_xref="InterPro:IPR003231" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:1F80" /db_xref="PDB:1HY8" /db_xref="PDB:2X2B" /db_xref="SubtiList:BG11536" /db_xref="UniProtKB/Swiss-Prot:P80643" /translation="MADTLERVTKIIVDRLGVDEADVKLEASFKEDLGADSLDVVELV MELEDEFDMEISDEDAEKIATVGDAVNYIQNQQ*" /label="acpA CDS" gene 1504025..1504258 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /label="acpA gene" downshifts 1504239 /Source="Nicolas_upshifts" /id="D883" /incds=0 /nref=22 /ntot=197 /MaxReadThrough="8.12206" /MaxDrop="4.1545" /score="-8.42930766" /energy="-17.4" /TU="U1306,U1307,U1308" /idTUdmin="U1306" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" promotor_no_box 1504267..1504367 /Source="Nicolas_upshift_promotors" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 1504327..1504397 /Source="Nicolas_S_feature" /locus_tag="new_1665639_1665709" /HighExp="LBGstat, dia5, Cold, LBGtran, C30, Diami, G135, LBGexp, G/S, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA, SigA" /TUshortPSig="0.031, 1, 1, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="0.991, 0.991" /label="S577" upshifts 1504327 /Source="Nicolas_upshifts" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1504398..1505147 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /EC_number="3.1.26.3" /experiment="publication(s) with functional evidences, PMID:11123676, 12682299, 16179796, 22412379, 23300471, 26883633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11123676, 12682299, 16179796, 22412379, 23300471, 26883633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease III" /protein_id="NP_389475.1" /db_xref="EnsemblGenomes-Gn:BSU15930" /db_xref="EnsemblGenomes-Tr:CAB13466" /db_xref="GOA:P51833" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR011907" /db_xref="InterPro:IPR014720" /db_xref="InterPro:IPR036389" /db_xref="SubtiList:BG11537" /db_xref="UniProtKB/Swiss-Prot:P51833" /translation="MSKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHS SYVNEHRKKPYEDNERLEFLGDAVLELTISRFLFAKYPAMSEGDLTKLRAAIVCEPSL VSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVY VFPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEP LGVGNGRSKKEAEQHAAQEALAKLQKHHTKQ*" /label="rnc CDS" gene 1504398..1505147 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /label="rnc gene" downshifts 1505119 /Source="Nicolas_upshifts" /id="D884" /incds=0 /nref=78 /ntot=211 /MaxReadThrough="6.42554" /MaxDrop="5.70849" /score="-8.42930766" /energy="-17.4" /TU="U1307,U1308,U1309" /idTUdmin="U1306" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1505189..1505195 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1505207..1505226 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1505229 /Source="Nicolas_upshifts" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1505248..1508808 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation SMC ATPase" /protein_id="NP_389476.2" /db_xref="EnsemblGenomes-Gn:BSU15940" /db_xref="EnsemblGenomes-Tr:CAB13467" /db_xref="GOA:P51834" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR010935" /db_xref="InterPro:IPR011890" /db_xref="InterPro:IPR024704" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036277" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5NMO" /db_xref="PDB:5NNV" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG11538" /db_xref="UniProtKB/Swiss-Prot:P51834" /translation="MFLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAI RWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTR RVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSI FEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEK KKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKI QALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETV LKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQ ASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHS QVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVK EVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQ NSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTV LITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDV TKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQV AEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQK QTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSF LTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMK RLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKR VKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMT KRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNL LSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIV ITHRKGTMEEADVLYGVTMQESGVSKVISVKLEETKEFVQ*" /label="smc CDS" gene 1505248..1508808 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /label="smc gene" S_feature complement(1508742..1509812) /Source="Nicolas_S_feature" /locus_tag="new_1670054_1671124_c" /HighExp="Cold, C30, Gly, T0.30H, Pyr, T-4.40H, G135, Lbstat, Fru, T-5.40H" /AntisenseName="ftsY" /AntisenseCor="-3.7172405649441298E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S578" CDS 1508828..1509817 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal recognition particle (docking protein)" /protein_id="NP_389477.1" /db_xref="EnsemblGenomes-Gn:BSU15950" /db_xref="EnsemblGenomes-Tr:CAB13468" /db_xref="GOA:P51835" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004390" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036225" /db_xref="SubtiList:BG11539" /db_xref="UniProtKB/Swiss-Prot:P51835" /translation="MSFFKKLKEKITKQTDSVSEKFKDGLEKTRNSFQNKVNDLVSRY RKVDEDFFEELEEVLISADVGFTTVMELIDELKKEVKRRNIQDPKEVQSVISEKLVEI YNSGDEQISELNIQDGRLNVILLVGVNGVGKTTTIGKLAHKMKQEGKSVVLAAGDTFR AGAIEQLEVWGERTGVPVIKQTAGSDPAAVIYDAVHAAKARNADVLICDTAGRLQNKV NLMKELEKVKRVIEREVPEAPHEVLLALDATTGQNAMAQAKEFSKATNVTGIALTKLD GTAKGGIVLAIRNELHIPVKLVGLGEKVDDLQEFDPESYVYGLFSDLVEKADD*" /label="ftsY CDS" gene 1508828..1509817 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /label="ftsY gene" downshifts 1509804 /Source="Nicolas_upshifts" /id="D885" /incds=0 /nref=220 /ntot=261 /MaxReadThrough="2.98458" /MaxDrop="6.84303" /score="49.5808683" /energy="-14.4" /TU="NA" /idTUdmin="U1307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1509854..1510339) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535, 22287527" /codon_start=1 /transl_table=11 /product="conserved exported protein of unknown function" /protein_id="NP_389478.1" /db_xref="EnsemblGenomes-Gn:BSU15960" /db_xref="EnsemblGenomes-Tr:CAB13469" /db_xref="GOA:O31737" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="SubtiList:BG13401" /db_xref="UniProtKB/Swiss-Prot:O31737" /translation="MKKIGLLFMLCLAALFTIGFPAQQADAAEAPYKASITNISTDGG VYGKINYGQGQYWRVKYNITVSGKLLDQNGQPVPNAPVRFEADTKVGNTTQTASGTTD ANGTFEVPMYLGPAAGYYTYYTSVSVHYYDIIPFRVFSGESRLVSTDNSLYHFAYQVR R*" /label="ylqB CDS" gene complement(1509854..1510339) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /label="ylqB gene" downshifts complement(1509857) /Source="Nicolas_upshifts" /id="D886" /incds=0 /nref=139 /ntot=244 /MaxReadThrough="6.77251" /MaxDrop="6.10895" /score="32.8428224" /energy="-14.4" /TU="U1311" /idTUdmin="U1311" /TUdmin="-1076" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1510361..1510379) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1510377) /Source="Nicolas_upshifts" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1510393..1510400) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1510442..1510448 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1510463..1510482 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1510465 /Source="Nicolas_upshifts" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1510516..1510848 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11274114, 24659773; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the signal recognition particle (SRP) protein-targeting pathway" /protein_id="NP_389479.1" /db_xref="EnsemblGenomes-Gn:BSU15970" /db_xref="EnsemblGenomes-Tr:CAB13470" /db_xref="GOA:P37104" /db_xref="InterPro:IPR007394" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10829" /db_xref="UniProtKB/Swiss-Prot:P37104" /translation="MSLEKTTRMNYLFDFYQSLLTSKQKSYMSLYYLDDFSLGEIAEE YEVSRQAVYDNIKRTEAMLEQYEEKLLLLKKFQERKEMFNKLKELASGSKEEEEITAL IEALEKLD*" /label="ylxM CDS" gene 1510516..1510848 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /label="ylxM gene" downshifts complement(1510519) /Source="Nicolas_upshifts" /id="D887" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="1.40385" /MaxDrop="4.6092" /score="32.8428224" /energy="-14.4" /TU="NA" /idTUdmin="U1311" /TUdmin="-1738" /isTUend="FALSE" /label="downshifts" CDS 1510862..1512202 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal recognition particle-like (SRP) GTPase" /protein_id="NP_389480.1" /db_xref="EnsemblGenomes-Gn:BSU15980" /db_xref="EnsemblGenomes-Tr:CAB13471" /db_xref="GOA:P37105" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004125" /db_xref="InterPro:IPR004780" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR022941" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036891" /db_xref="PDB:4UE4" /db_xref="SubtiList:BG10830" /db_xref="UniProtKB/Swiss-Prot:P37105" /translation="MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADV NFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIAVAKRPPT VIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV FSLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEI FLVVDSMTGQDAVNVAKSFNEQLGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGL GEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKELEQKMRTMSFTLDDF LEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPD IINASRRKRIAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM*" /label="ffh CDS" gene 1510862..1512202 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /label="ffh gene" S_feature 1512203..1512307 /Source="Nicolas_S_feature" /locus_tag="new_1673515_1673619" /HighExp="Cold, G135, C30, G180, LPhT, HPh, Paraq, LPh, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S579" CDS 1512308..1512580 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6419023, 12682299, 20034956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6419023, 12682299, 20034956; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S16 (BS17)" /protein_id="NP_389481.1" /db_xref="EnsemblGenomes-Gn:BSU15990" /db_xref="EnsemblGenomes-Tr:CAB13472" /db_xref="GOA:P21474" /db_xref="InterPro:IPR000307" /db_xref="InterPro:IPR020592" /db_xref="InterPro:IPR023803" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10831" /db_xref="UniProtKB/Swiss-Prot:P21474" /translation="MAVKIRLKRMGAKKSPFYRIVVADSRSPRDGRFIETVGTYNPVA KPAEVKIDEELALKWLQTGAKPSDTVRNLFSSQGIMEKFHNAKQGK*" /label="rpsP CDS" gene 1512308..1512580 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /label="rpsP gene" CDS 1512580..1512825 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735, 26483775; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_389482.1" /db_xref="EnsemblGenomes-Gn:BSU16000" /db_xref="EnsemblGenomes-Tr:CAB13473" /db_xref="GOA:O31738" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020627" /db_xref="SubtiList:BG13402" /db_xref="UniProtKB/Swiss-Prot:O31738" /translation="MTDQHLEDLIVHIVTPLVDHPDDIRVIREETDQKIALRLSVHKS DTGKVIGKQGRTAKAIRTAVFAAGVQSSKKVQFEIFD*" /label="ylqC CDS" gene 1512580..1512825 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /label="ylqC gene" downshifts 1512797 /Source="Nicolas_upshifts" /id="D888" /incds=0 /nref=41 /ntot=178 /MaxReadThrough="6.57974" /MaxDrop="4.803" /score="-7.01631592" /energy="-5.6" /TU="U1312" /idTUdmin="U1312" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" S_feature 1512842..1512946 /Source="Nicolas_S_feature" /locus_tag="new_1674154_1674258" /HighExp="G180, Oxctl, G150, G135, Paraq, LBGexp, H2O2, HPh, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S580" CDS 1512947..1513333 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389483.1" /db_xref="EnsemblGenomes-Gn:BSU16010" /db_xref="EnsemblGenomes-Tr:CAB13474" /db_xref="InterPro:IPR021297" /db_xref="SubtiList:BG13403" /db_xref="UniProtKB/Swiss-Prot:O31739" /translation="MQIIHRVAVMQVLTERSKEKLLASFAEKKQMLERECSQLYFQLR KHEKEQQNPNMIEQFKKAIEKRKDDIKIIDFQIAQVHTLPLGSELKEKEVDALLTIEA GDDWHEKTAANTIVIKDGKVIEIRQR*" /label="ylqD CDS" gene 1512947..1513333 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /label="ylqD gene" CDS 1513338..1513862 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15496525, 16014871, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="16S rRNA processing protein" /protein_id="NP_389484.1" /db_xref="EnsemblGenomes-Gn:BSU16020" /db_xref="EnsemblGenomes-Tr:CAB13475" /db_xref="GOA:O31740" /db_xref="InterPro:IPR002676" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR011961" /db_xref="InterPro:IPR027275" /db_xref="InterPro:IPR036976" /db_xref="SubtiList:BG13404" /db_xref="UniProtKB/Swiss-Prot:O31740" /translation="MTKRWFNVGKIVNTHGIKGEVRVISKTDFAEERYKPGNTLYLFM DGRNEPVEVTVNTHRLHKQFHLLQFKERQNLNEVEELKNAIIKVPEEELGELNEGEFY FHEIIGCEVFTEEGELIGKVKEILTPGANDVWVIGRKGKKDALIPYIESVVKHIDVRE KKIEIELMEGLIDE*" /label="rimM CDS" gene 1513338..1513862 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /label="rimM gene" CDS 1513859..1514590 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /EC_number="2.1.1.228" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094308, 11532950, 12682299, 12773376, 15060037, 27881678, 28601227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(m1G37)methyltransferase" /protein_id="NP_389485.1" /db_xref="EnsemblGenomes-Gn:BSU16030" /db_xref="EnsemblGenomes-Tr:CAB13476" /db_xref="GOA:O31741" /db_xref="InterPro:IPR002649" /db_xref="InterPro:IPR016009" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG12687" /db_xref="UniProtKB/Swiss-Prot:O31741" /translation="MKIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDN KHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSKAAAAPRIILVCPQGERFTQKKAEQL AKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSVVRLLPGVL GKEASHIEDSFSTGLLEHPHYTRPADYKGLKVPETLLSGNHAKIEEWRNKESIRRTYL RRPDLLKDHPLTEQQRKWISEWEKE*" /label="trmD CDS" gene 1513859..1514590 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /label="trmD gene" promotor_-35 1514596..1514603 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1514617..1514636 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1514621 /Source="Nicolas_upshifts" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" misc_RNA 1514669..1514710 /locus_tag="BSU_misc_RNA_30" /product="L19_leader" /label="L19 leader RNA" gene 1514669..1514710 /locus_tag="BSU_misc_RNA_30" /label="gene" CDS 1514730..1515077 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16272117, 27477481; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L19" /protein_id="NP_389486.2" /db_xref="EnsemblGenomes-Gn:BSU16040" /db_xref="EnsemblGenomes-Tr:CAB13477" /db_xref="GOA:O31742" /db_xref="InterPro:IPR001857" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR018257" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12667" /db_xref="UniProtKB/Swiss-Prot:O31742" /translation="MQKLIEDITKEQLRTDLPAFRPGDTLRVHVKVVEGNRERIQIFE GVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPKIAKIEVVRYGKVRRAKLYYLRE LRGKAARIKEIRR*" /label="rplS CDS" gene 1514730..1515077 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /label="rplS gene" downshifts 1515079 /Source="Nicolas_upshifts" /id="D889" /incds=0 /nref=212 /ntot=274 /MaxReadThrough="6.00308" /MaxDrop="9.06015" /score="23.9942041" /energy="-12.6" /TU="U1313" /idTUdmin="U1312" /TUdmin=478 /isTUend="FALSE" /label="downshifts" promotor_-35 1515132..1515138 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1515151..1515219 /Source="Nicolas_S_feature" /locus_tag="new_1676463_1676531" /HighExp="Oxctl, G180, Paraq, G135, H2O2, LBGstat, dia15, G150, HPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.149563" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S581" upshifts 1515151 /Source="Nicolas_upshifts" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1515152..1515171 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1515220..1516068 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome biogenesis GTPase A" /protein_id="NP_389487.1" /db_xref="EnsemblGenomes-Gn:BSU16050" /db_xref="EnsemblGenomes-Tr:CAB13478" /db_xref="GOA:O31743" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016478" /db_xref="InterPro:IPR019991" /db_xref="InterPro:IPR023179" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="PDB:1PUJ" /db_xref="SubtiList:BG13405" /db_xref="UniProtKB/Swiss-Prot:O31743" /translation="MTIQWFPGHMAKARREVTEKLKLIDIVYELVDARIPMSSRNPMI EDILKNKPRIMLLNKADKADAAVTQQWKEHFENQGIRSLSINSVNGQGLNQIVPASKE ILQEKFDRMRAKGVKPRAIRALIIGIPNVGKSTLINRLAKKNIAKTGDRPGITTSQQW VKVGKELELLDTPGILWPKFEDELVGLRLAVTGAIKDSIINLQDVAVFGLRFLEEHYP ERLKERYGLDEIPEDIAELFDAIGEKRGCLMSGGLINYDKTTEVIIRDIRTEKFGRLS FEQPTM*" /label="rbgA CDS" gene 1515220..1516068 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /label="rbgA gene" promotor_-35 1516089..1516096 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1516109..1516127 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1516119 /Source="Nicolas_upshifts" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1516139..1516906 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /EC_number="3.1.26.4" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10094689, 12475934, 23882084, 23937561, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094689, 12475934, 23882084, 23937561, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HII" /protein_id="NP_389488.1" /db_xref="EnsemblGenomes-Gn:BSU16060" /db_xref="EnsemblGenomes-Tr:CAB13479" /db_xref="GOA:O31744" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR022898" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12666" /db_xref="UniProtKB/Swiss-Prot:O31744" /translation="MNTLTVKDIKDRLQEVKDAQDPFIAQCENDPRKSVQTLVEQWLK KQAKEKALKEQWVNMTSYERLARNKGFRLIAGVDEVGRGPLAGPVVASAVILPEECEI LGLTDSKKLSEKKREEYYELIMKEALAVGIGIVEATVIDEINIYEASKMAMVKAIQDL SDTPDYLLVDAMTLPLDTAQASIIKGDAKSVSIAAGACIAKVTRDRMMSAYAETYPMY GFEKNKGYGTKEHLEALAAYGPTELHRKTFAPVQSFR*" /label="rnhB CDS" gene 1516139..1516906 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /label="rnhB gene" CDS 1516938..1518668 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389489.1" /db_xref="EnsemblGenomes-Gn:BSU16070" /db_xref="EnsemblGenomes-Tr:CAB13480" /db_xref="SubtiList:BG13406" /db_xref="UniProtKB/Swiss-Prot:O31745" /translation="MNIRNDVQKALQHLFGRTAVPQETSKVNEALNGEKRLLLGKVLR LLGDQHALIQVGNQTVQGKLETQLRPQAYYWFSYEKKTAEQTGRLQVVQSFDQNPKTI QDAAGKLLNAISVKTSNAALMMTGAMLKSKTPVTENDIKTAVRWMDTLPSQDTKKAVE TVLFALKRDLPIHSEILNGVHAVKSPVPLHQHVSQLLQAIDQNPQQSQMMSKLKEAVT VLLNSEIDVHAERLIDKLISLTDNTKAPSPTNTAGSRELSTPAGSPGKASLPIANHTA EQGSIQEEPVKTAADIPIKEARQLLVKLTESAEKNSLQIVKEAANWIKAAASSGDSKS LAASAVLQAAQVTDQEAEVFLKAVQQTAPHLADKADVLSFLSKVKTAIGARDEVAFIK AFEQGSAVTSGEMQSIKLALSALRASHEVAEPVKQEADQLFHKLNGQLFMQQDHPSYS QIVMSFPMFSKSGVQDMTVLFKGKKEADGKLDPSHCRLLFLLQLDTLKETVVDCLVQQ KVMTITIETDFELQAAIDPMVPALKQGLKEMGYSLSGVNAKKRVHTEEKASIDQYITS ISDQEVDVKI*" /label="ylqG CDS" gene 1516938..1518668 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /label="ylqG gene" upshifts complement(1518175) /Source="Nicolas_upshifts" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1518176..1518195) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1518210..1518217) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1518665..1518946 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative flagellar biosynthesis protein" /protein_id="NP_389490.1" /db_xref="EnsemblGenomes-Gn:BSU16080" /db_xref="EnsemblGenomes-Tr:CAB13481" /db_xref="GOA:O34867" /db_xref="InterPro:IPR004683" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13407" /db_xref="UniProtKB/Swiss-Prot:O34867" /translation="MKEQTPIRKAVALHYDEQKDKAPRVIATGKGHVADNIIKEAKKA GVPIQEDRTLVELMRHLTVDDQIPEALYETVAEIFSFIYKLDESVKNKK*" /label="ylqH CDS" gene 1518665..1518946 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /label="ylqH gene" downshifts 1518778 /Source="Nicolas_upshifts" /id="D890" /incds=1 /nref=7 /ntot=136 /MaxReadThrough="4.03339" /MaxDrop="4.52065" /score="-6.81136789" /energy="-9.2" /TU="U1313,U1315" /idTUdmin="U1313" /TUdmin="-267" /isTUend="FALSE" /label="downshifts" S_feature 1518947..1519066 /Source="Nicolas_S_feature" /locus_tag="new_1680259_1680378" /HighExp="Cold, Lbstat, H2O2, Glu, Paraq, Mal, G135, GM 90, Oxctl, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S582" promotor_-35 1519038..1519045 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1519059..1519078 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1519068 /Source="Nicolas_upshifts" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1519119..1520276 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2548486, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (beta subunit)" /protein_id="NP_389491.1" /db_xref="EnsemblGenomes-Gn:BSU16090" /db_xref="EnsemblGenomes-Tr:CAB13482" /db_xref="GOA:P80886" /db_xref="InterPro:IPR005809" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013650" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017866" /db_xref="SubtiList:BG12680" /db_xref="UniProtKB/Swiss-Prot:P80886" /translation="MNIHEYQGKEVLRKYGVSVPEGKVAFTAEEAVESAKSLSSSVYV VKAQIHAGGRGKAGGVKIAKSLDEVKAYAEELLGKTLVTHQTGPDGQVIKRLLIEEGC DIKKEYYIGLVLDRATSRIVLMASEEGGTEIEEVAEKTPEKIKKAVIDPAVGLQGYQA REIAFAINIPKELVGKAAKFMLGLYKAFVEKDCSIAEINPLVVTGDGNVMALDAKLNF DSNALYRQKDIMEYRDLDEEDPKEIEASKYDLSYISLDGNIGCMVNGAGLAMSTMDII KHYGGEPANFLDVGGGATAEKVTEAFKIILSDQNVKGIFVNIFGGIMKCDVIAEGVVE ATRQVGLTLPLVVRLEGTNVDLGKKILSESGLNITSAESMADGAQKIVSLV*" /label="sucC CDS" gene 1519119..1520276 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /label="sucC gene" promotor_no_box complement(1519191..1519291) /Source="Nicolas_upshift_promotors" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1519231) /Source="Nicolas_upshifts" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1520305..1521207 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9643546, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (alpha subunit)" /protein_id="NP_389492.1" /db_xref="EnsemblGenomes-Gn:BSU16100" /db_xref="EnsemblGenomes-Tr:CAB13483" /db_xref="GOA:P80865" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR005810" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017440" /db_xref="InterPro:IPR033847" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12681" /db_xref="UniProtKB/Swiss-Prot:P80865" /translation="MSVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKG GTEAEGVPVFNTVAEAVQTTGANASVIYVPAPFAADAIMEAVDAELDLVICITEHIPV LDMVKVKRFMEGKKTRLIGPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYE AVHQLSEAGVGQSTAVGIGGDPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEA AEWVKANMTKPVVGFIGGKTAPPGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAET PSVMGETLIKVLKEKNLFETCKTH*" /label="sucD CDS" gene 1520305..1521207 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /label="sucD gene" downshifts 1521197 /Source="Nicolas_upshifts" /id="D891" /incds=0 /nref=94 /ntot=208 /MaxReadThrough="5.40077" /MaxDrop="4.8878" /score="9.51199539" /energy="-15" /TU="U1317" /idTUdmin="U1315" /TUdmin=2130 /isTUend="FALSE" /label="downshifts" CDS 1521268..1522161 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA processing Smf single strand binding protein" /protein_id="NP_389493.1" /db_xref="EnsemblGenomes-Gn:BSU16110" /db_xref="EnsemblGenomes-Tr:CAB13484" /db_xref="GOA:P39813" /db_xref="InterPro:IPR003488" /db_xref="SubtiList:BG11006" /db_xref="UniProtKB/Swiss-Prot:P39813" /translation="MDQAAVCLTICRINQLLSPSLLLKWWKADPSMSLTSPVLQTVTR DQIKAAALKNEIEQFYPKLPRVLAAYREQGINTIPISSKQYPFWLKSIYDPPAVLFAK GDMTLLSKGRKIGIVGTRNPTAYGKQVVNHLTKEICRKGWVIVSGLASGIDGMSHAAS IKAKGRTIGVIAGGFQHIYPRENLQLADHMAKHHILLSEHPPETKPQKWHFPMRNRII SGLSEGVIVVQGKEKSGSLITAYQALEQGREVFAVPGSLFDPYAGGPIKLIQQGAKAI WSAEDIFEELPERNVQYTEPF*" /label="dprA CDS" gene 1521268..1522161 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /label="dprA gene" promotor_-35 1522167..1522174 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1522189..1522208 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1522196..1522348 /Source="Nicolas_S_feature" /locus_tag="new_1683508_1683660" /HighExp="dia15, H2O2, G/S, Paraq, Diami, S1, Oxctl, LBGexp, C30, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.111279" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigD, SigA, SigA" /TUlongPSig="1, 1, 1" /label="S583" upshifts 1522196 /Source="Nicolas_upshifts" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1522349..1524424 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /EC_number="5.99.1.2" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9580687, 12682299, 16585761, 23133654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9580687, 12682299, 16585761, 23133654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase I" /protein_id="NP_389494.1" /db_xref="EnsemblGenomes-Gn:BSU16120" /db_xref="EnsemblGenomes-Tr:CAB13485" /db_xref="GOA:P39814" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005733" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013498" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR028612" /db_xref="InterPro:IPR034149" /db_xref="SubtiList:BG11007" /db_xref="UniProtKB/Swiss-Prot:P39814" /translation="MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGV DIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDL NSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKK GLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPL NSEADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMM IAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRKPA KKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMS VDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPE QHFTQPPPRYTEARLVKTLEERGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQI VLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKKAESEMK EVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGE GNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVE CDYKEEPQK*" /label="topA CDS" gene 1522349..1524424 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /label="topA gene" downshifts 1524394 /Source="Nicolas_upshifts" /id="D892" /incds=0 /nref=48 /ntot=173 /MaxReadThrough="5.66787" /MaxDrop="4.5486" /score="0.939045188" /energy="-13.2" /TU="U1319" /idTUdmin="U1317" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 1524456..1524461 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1524468 /Source="Nicolas_upshifts" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1524477..1524495 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1524500..1525807 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /EC_number="2.1.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16027442, 21561081, 23095745, 23157377, 27825927, 28745052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16027442, 21561081, 23095745, 23157377, 27825927, 28745052; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA:m(5)U-54 methyltransferase" /protein_id="NP_389495.1" /db_xref="EnsemblGenomes-Gn:BSU16130" /db_xref="EnsemblGenomes-Tr:CAB13486" /db_xref="GOA:P39815" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004417" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11008" /db_xref="UniProtKB/Swiss-Prot:P39815" /translation="MNQQTVNVIGAGLAGSEAAWQLAKRGIQVKLYEMRPVKQTPAHH TDKFAELVCSNSLRSNTLANAVGVLKEEMRALDSAIIAAADECSVPAGGALAVDRHEF AASVTNRVKNHPNVTVINEEVTEIPEGPTIIATGPLTSESLSAQLKELTGEDYLYFYD AAAPIVEKDSLDMDKVYLKSRYDKGEAAYLNCPMTEEEFDRFHEALTSAETVPLKEFE KEIFFEGCMPIEVMAKRGKKTMLFGPMKPVGLEHPVTGKRPYAVVQLRQDDAAGTLYN IVGFQTHLKWGDQKEVLKLIPGLENVEIVRYGVMHRNTFINSPSLLKPTYQFKNRSDL FFAGQMTGVEGYVESAASGLVAGINAAKLVLGEELVIFPQETAIGSMAHYITTTNQKN FQPMNANFGLLKELPVKIKNKKERNEQYANRAIETIQTISKTI*" /label="trmFO CDS" gene 1524500..1525807 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /label="trmFO gene" promotor_-35 1525813..1525817 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1525834..1525853 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1525844 /Source="Nicolas_upshifts" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1525875..1526789 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /function="16.9: Replicate" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11208805, 16553881, 16597952, 21239579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11208805, 16553881, 16597952, 21239579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_389496.1" /db_xref="EnsemblGenomes-Gn:BSU16140" /db_xref="EnsemblGenomes-Tr:CAB13487" /db_xref="GOA:P39776" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011931" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG10965" /db_xref="UniProtKB/Swiss-Prot:P39776" /translation="MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQG INGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFLMREKLIEENPFQLVH LPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRG GPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLS STQIYTHVSKEMLRNTYMSHHPRAFKKN*" /label="codV CDS" gene 1525875..1526789 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /label="codV gene" promotor_-35 1525914..1525918 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-35" upshifts 1525931 /Source="Nicolas_upshifts" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="upshifts" promotor_-10 1525934..1525953 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-10" CDS 1526802..1527347 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /EC_number="3.4.25.2" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (N-terminalserine protease)" /protein_id="NP_389497.1" /db_xref="EnsemblGenomes-Gn:BSU16150" /db_xref="EnsemblGenomes-Tr:CAB13488" /db_xref="GOA:P39070" /db_xref="InterPro:IPR001353" /db_xref="InterPro:IPR022281" /db_xref="InterPro:IPR023333" /db_xref="InterPro:IPR029055" /db_xref="PDB:1YYF" /db_xref="PDB:2Z3A" /db_xref="PDB:2Z3B" /db_xref="SubtiList:BG10966" /db_xref="UniProtKB/Swiss-Prot:P39070" /translation="MSSFHATTIFAVQHKGRSAMSGDGQVTFGQAVVMKHTARKVRKL FNGKVLAGFAGSVADAFTLFEKFEAKLEEYNGNLKRAAVELAKEWRSDKVLRKLEAML IVMNQDTLLLVSGTGEVIEPDDGILAIGSGGNYALAAGRALKKHAGESMSASEIARAA LETAGEICVYTNDQIILEELE*" /label="clpQ CDS" gene 1526802..1527347 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /label="clpQ gene" CDS 1527364..1528767 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (ATPase andchaperone)" /protein_id="NP_389498.1" /db_xref="EnsemblGenomes-Gn:BSU16160" /db_xref="EnsemblGenomes-Tr:CAB13489" /db_xref="GOA:P39778" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004491" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10967" /db_xref="UniProtKB/Swiss-Prot:P39778" /translation="MEKKPLTPRQIVDRLDQYIVGQQNAKKAVAVALRNRYRRSLLDE KLKDEVVPKNILMMGPTGVGKTEIARRIAKLSGAPFIKIEATKFTEVGYVGRDVESMV RDLVETSVRLIKEEKMNEVKEQAEENANKRIVRLLVPGKKKQSGVKNPFEMFFGGSQP NGEDEAESQEEANIEEKRKRMAHQLALGELEDYYVTVEVEEQQPSMFDMLQGSGMEQM GMNMQDALSGLMPKKKKRRKMTVREARKVLTNEEASKLIDMDEVGQEAVQRAEESGII FIDEIDKIAKNGGASSSADVSREGVQRDILPIVEGSTVVTKYGSVKTDHVLFIAAGAF HMAKPSDLIPELQGRFPIRVELNKLTVDDFVRILVEPDNALLKQYQALLQTEGISLEF SDEAIHKIAEVAYHVNQDTDNIGARRLHTILERLLEDLSFEAPDVTMEKITITPQYVE EKLGTIAKNKDLSQFIL*" /label="clpY CDS" gene 1527364..1528767 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /label="clpY gene" CDS 1528807..1529586 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, GTP and BCAA-dependent" /protein_id="NP_389499.1" /db_xref="EnsemblGenomes-Gn:BSU16170" /db_xref="EnsemblGenomes-Tr:CAB13490" /db_xref="GOA:P39779" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR013198" /db_xref="InterPro:IPR014154" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2B0L" /db_xref="PDB:2B18" /db_xref="PDB:2GX5" /db_xref="PDB:2HGV" /db_xref="PDB:5LNH" /db_xref="PDB:5LOE" /db_xref="PDB:5LOJ" /db_xref="PDB:5LOO" /db_xref="SubtiList:BG10968" /db_xref="UniProtKB/Swiss-Prot:P39779" /translation="MALLQKTRIINSMLQAAAGKPVNFKEMAETLRDVIDSNIFVVSR RGKLLGYSINQQIENDRMKKMLEDRQFPEEYTKNLFNVPETSSNLDINSEYTAFPVEN RDLFQAGLTTIVPIIGGGERLGTLILSRLQDQFNDDDLILAEYGATVVGMEILREKAE EIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGNEGLLVASKIADRVGITRSVIV NALRKLESAGVIESRSLGMKGTYIKVLNNKFLIELENLKSH*" /label="codY CDS" gene 1528807..1529586 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /label="codY gene" downshifts 1529561 /Source="Nicolas_upshifts" /id="D893" /incds=0 /nref=6 /ntot=130 /MaxReadThrough="5.35492" /MaxDrop="5.90286" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1529605 /Source="Nicolas_upshifts" /id="D894" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="4.95658" /MaxDrop="4.85551" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1529706..1529713 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1529726..1529744 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1529737..1529890 /Source="Nicolas_S_feature" /locus_tag="new_1691049_1691202" /HighExp="C30, GM 90, GM 25, Cold, GM 15, GM 10, MG 150, GM-0.2, LBGstat, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 0.994, 0.998" /TUlongSig="SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.999, 1, 1, 1" /label="S584" upshifts 1529737 /Source="Nicolas_upshifts" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1529865..1529872 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1529887..1529906 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1529892 /Source="Nicolas_upshifts" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1529966..1530355 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996, 17850253, 25843804; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389500.1" /db_xref="EnsemblGenomes-Gn:BSU16180" /db_xref="EnsemblGenomes-Tr:CAB13491" /db_xref="GOA:P24500" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006300" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10237" /db_xref="UniProtKB/Swiss-Prot:P24500" /translation="MSLFSGTIQNLENALSRADIKQKVITNNIANIDTPNYKAKKVSF QNLLDQESSRLEAIKTDYRHVDFSDTDSNYSIVASGDTSYQQNGNNVDVDKEMTELAQ NQINYQALVERMNGKFNSLKTVLTGGK*" /label="flgB CDS" gene 1529966..1530355 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /label="flgB gene" CDS 1530355..1530807 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389501.1" /db_xref="EnsemblGenomes-Gn:BSU16190" /db_xref="EnsemblGenomes-Tr:CAB13492" /db_xref="GOA:P24501" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006299" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10238" /db_xref="UniProtKB/Swiss-Prot:P24501" /translation="MTAFHSLNVSASALTAQRVRMDVVSSNLANMDTTRAKQVNGEWV PYRRKMVSLQSKGESFSSILNSQMSGSGNAGNGVKVSKITEDDSDFNLVYDPTDPDAN AEGYVQKPNVDPLKEMVDLVSSTRSYEANVTAMNATKGMLMKALEIGK*" /label="flgC CDS" gene 1530355..1530807 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /label="flgC gene" SCAR 1530808..1530809 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_004" CDS 1530864..1531628 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-28 factor (sigma-D)" /protein_id="NP_389529.1" /db_xref="EnsemblGenomes-Gn:BSU16470" /db_xref="EnsemblGenomes-Tr:CAB13520" /db_xref="GOA:P10726" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR012845" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10751" /db_xref="UniProtKB/Swiss-Prot:P10726" /translation="MQSLNYEDQVLWTRWKEWKDPKAGDDLMRRYMPLVTYHVGRISV GLPKSVHKDDLMSLGMLGLYDALEKFDPSRDLKFDTYASFRIRGAIIDGLRKEDWLPR TSREKTKKVEAAIEKLEQRYLRNVSPAEIAEELGMTVQDVVSTMNEGFFANLLSIDEK LHDQDDGENIQVMIRDDKNVPPEEKIMKDELIAQLAEKIHELSEKEQLVVSLFYKEEL TLTEIGQVLNLSTSRISQIHSKALFKLKNLLEKVIQ*" /label="sigD CDS" gene 1530864..1531628 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /label="sigD gene" promotor_-35 1531638..1531644 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" CDS 1531657..1532160 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15066026, 15175317, 19202088, 21736639, 26244495" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 15175317, 19202088, 21736639, 26244495; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling factor for flagellin transcription and translation" /protein_id="NP_389530.1" /db_xref="EnsemblGenomes-Gn:BSU16480" /db_xref="EnsemblGenomes-Tr:CAB13521" /db_xref="SubtiList:BG10752" /db_xref="UniProtKB/Swiss-Prot:P40405" /translation="MSTLLWLLSFMLHGVLLYAVIILYTRLAAVKETEKQQKQILEET ENTLAAFLLELKEENEKLIENKASSASQSDEESQKSGLQTSETYQERDPVQEAENLPE HIEGLITEVDRREELVNSEVQSFEDQVIELYEQGYSASQIAQKMKSGKTEIELFLKFR SKGVKDS*" /label="swrB CDS" gene 1531657..1532160 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /label="swrB gene" promotor_-10 1531659..1531670 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1531673 /Source="Nicolas_upshifts" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1532156..1532162 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1532177..1532196 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1532179..1532303 /Source="Nicolas_S_feature" /locus_tag="new_1717808_1717932" /HighExp="GM 45, GM 15, H2O2, M9-exp, LBGexp, C30, MG 90, GM-0.1, G135, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S586" upshifts 1532179 /Source="Nicolas_upshifts" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1532304..1533044 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9090122, 10675340, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S2" /protein_id="NP_389531.1" /db_xref="EnsemblGenomes-Gn:BSU16490" /db_xref="EnsemblGenomes-Tr:CAB13522" /db_xref="GOA:P21464" /db_xref="InterPro:IPR001865" /db_xref="InterPro:IPR005706" /db_xref="InterPro:IPR018130" /db_xref="InterPro:IPR023591" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19004" /db_xref="UniProtKB/Swiss-Prot:P21464" /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQ KTVKKVEEAYNFTKNLAAEGGKILFVGTKKQAQDSVKEEAQRSGMYYVNQRWLGGTLT NFETIQKRIKRLKDIEKMQENGTFDVLPKKEVVQLKKELERLEKFLGGIKDMKDLPDA LFIIDPRKERIAVAEARKLNIPIIGIVDTNCDPDEIDVVIPANDDAIRAVKLLTSKMA DAILEAKQGEEEAEVAEETAPETETTTA*" /label="rpsB CDS" gene 1532304..1533044 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /label="rpsB gene" downshifts 1533026 /Source="Nicolas_upshifts" /id="D896" /incds=0 /nref=4 /ntot=61 /MaxReadThrough="9.04923" /MaxDrop="4.1312" /score="7.42766835" /energy="-14.3" /TU="U1324,U1328" /idTUdmin="U1323" /TUdmin=869 /isTUend="FALSE" /label="downshifts" S_feature 1533071..1533145 /Source="Nicolas_S_feature" /locus_tag="new_1718700_1718774" /HighExp="LPh, dia0, G150, G180, LBGexp, Lbexp, HPh, Oxctl, dia15, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S587" CDS 1533146..1534027 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6396082, 9244380, 9973356, 27624934; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor Ts" /protein_id="NP_389532.1" /db_xref="EnsemblGenomes-Gn:BSU16500" /db_xref="EnsemblGenomes-Tr:CAB13523" /db_xref="GOA:P80700" /db_xref="InterPro:IPR001816" /db_xref="InterPro:IPR009060" /db_xref="InterPro:IPR014039" /db_xref="InterPro:IPR018101" /db_xref="InterPro:IPR036402" /db_xref="SubtiList:BG19025" /db_xref="UniProtKB/Swiss-Prot:P80700" /translation="MAITAQQVKELREKTGAGMMDCKKALTETDGDMDKAIDLLREKG IAKAAKKADRIAAEGSTLIKTDGNKGVILEVNSETDFVAKNEGFKELLNTLADHLLAN TPADVEEAMGQKMENGSTVEEYITSAVAKIGEKITLRRFTVLTKDDSSAFGAYLHMGG RIGVLTVLNGTTDEETAKDIAMHVAAVNPRYISRDQVSEEETNHERQILTQQALQEGK PENIVAKMVEGRLNKFFEEICLLDQAFVKNPDEKVKQVIAAKNATVQTFVRYEVGEGI EKRQENFAEEVMNQVKK*" /label="tsf CDS" gene 1533146..1534027 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /label="tsf gene" S_feature 1534028..1534172 /Source="Nicolas_S_feature" /locus_tag="new_1719657_1719801" /HighExp="LBGexp, G150, LBGtran, G135, G180, LPh, Oxctl, dia0, Lbexp, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S588" CDS 1534173..1534895 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /EC_number="2.7.4.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9862121, 12682299, 12869195, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9862121, 12682299, 12869195, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridylate kinase" /protein_id="NP_389533.2" /db_xref="EnsemblGenomes-Gn:BSU16510" /db_xref="EnsemblGenomes-Tr:CAB13524" /db_xref="GOA:O31749" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR011817" /db_xref="InterPro:IPR015963" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12675" /db_xref="UniProtKB/Swiss-Prot:O31749" /translation="MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAEL EVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLATVMNSLALQDSLETLGIQSRVQ TSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM AKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSI MEEGNIKRAVIGESIGTIVRGK*" /label="pyrH CDS" gene 1534173..1534895 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /label="pyrH gene" CDS 1534897..1535454 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9862121, 12480895, 12682299, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome recycling factor" /protein_id="NP_389534.1" /db_xref="EnsemblGenomes-Gn:BSU16520" /db_xref="EnsemblGenomes-Tr:CAB13525" /db_xref="GOA:P81101" /db_xref="InterPro:IPR002661" /db_xref="InterPro:IPR023584" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12587" /db_xref="UniProtKB/Swiss-Prot:P81101" /translation="MSKEVLTQTKEKMEKAIAAYQRELATVRAGRANPSLLDKVTVEY YGAQTPLNQLSSINVPEARMLVITPYDKTAIGDIEKAILKADLGLTPTSDGNMIRIAI PALTEERRKELVKVVKKYAEEAKVAVRNVRRDANDDLKKLEKNGDITEDELRASTEDV QKLTDEYVSKIDSVTKDKEKEIMEV*" /label="frr CDS" gene 1534897..1535454 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /label="frr gene" downshifts complement(1535401) /Source="Nicolas_upshifts" /id="D897" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="3.38183" /MaxDrop="3.17183" /score="-5.69560888" /energy="-4.8" /TU="NA" /idTUdmin="U1326" /TUdmin="-10739" /isTUend="FALSE" /label="downshifts" promotor_-35 1535443..1535446 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1535461..1535480 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1535479..1535584 /Source="Nicolas_S_feature" /locus_tag="new_1721108_1721213" /HighExp="G180, G135, T3.30H, Oxctl, G150, Cold, Paraq, C30, T3.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S589" upshifts 1535479 /Source="Nicolas_upshifts" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1535585..1536367 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /EC_number="2.5.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15788389, 16014871, 22904278, 23840410, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15788389, 16014871, 22904278, 23840410, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate synthase" /protein_id="NP_389535.1" /db_xref="EnsemblGenomes-Gn:BSU16530" /db_xref="EnsemblGenomes-Tr:CAB13526" /db_xref="GOA:O31751" /db_xref="InterPro:IPR001441" /db_xref="InterPro:IPR018520" /db_xref="InterPro:IPR036424" /db_xref="SubtiList:BG13408" /db_xref="UniProtKB/Swiss-Prot:O31751" /translation="MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGR WAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKL PEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYG GRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNF MLWQVAYSEFVFTDVLWPDFKEDHFLQALGEFQQRGRRFGGI*" /label="uppS CDS" gene 1535585..1536367 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /label="uppS gene" CDS 1536371..1537180 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /EC_number="2.7.7.41" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 175832, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidate cytidylyltransferase (CDP-diglyceride synthase)" /protein_id="NP_389536.1" /db_xref="EnsemblGenomes-Gn:BSU16540" /db_xref="EnsemblGenomes-Tr:CAB13527" /db_xref="GOA:O31752" /db_xref="InterPro:IPR000374" /db_xref="SubtiList:BG12575" /db_xref="UniProtKB/Swiss-Prot:O31752" /translation="MVDMKQRILTGVLAAIVFLFLVIVGKLPFTILIYAMGSVALFEL LRMKKLKLVSLPGLIGLLLLWMFLLPSQYSFFEADGISKMEIALFAVLLLLTYTVLVK NTFTFDEVGFITLAAIYIGMCFHYFIEIRNLDQYGLTYIFYACVVIWSTDSGAYFVGK SLGKRKLWPEISPNKTVEGFAGGIVIALVLATIFQLVAQLPIPYIYLLLITLFLSVFG QLGDLVESALKRHYDVKDSGNILPGHGGILDRFDSFLFVMPFLYFLLALFS*" /label="cdsA" gene 1536371..1537180 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /label="cdsA gene" promotor_-35 1537161..1537168 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1537183..1537202 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1537184 /Source="Nicolas_upshifts" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1537242..1538393 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /EC_number="1.1.1.267" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15567415, 17458547, 21296950, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15567415, 17458547, 21296950, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase" /protein_id="NP_389537.2" /db_xref="EnsemblGenomes-Gn:BSU16550" /db_xref="EnsemblGenomes-Tr:CAB13528" /db_xref="GOA:O31753" /db_xref="InterPro:IPR003821" /db_xref="InterPro:IPR013512" /db_xref="InterPro:IPR013644" /db_xref="InterPro:IPR026877" /db_xref="InterPro:IPR036169" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13409" /db_xref="UniProtKB/Swiss-Prot:O31753" /translation="MKNICLLGATGSIGEQTLDVLRAHQDQFQLVSMSFGRNIDKAVP MIEVFQPKFVSVGDLDTYHKLKQMSFSFECQIGLGEEGLIEAAVMEEVDIVVNALLGS VGLIPTLKAIEQKKTIALANKETLVTAGHIVKEHAKKYDVPLLPVDSEHSAIFQALQG EQAKNIERLIITASGGSFRDKTREELESVTVEDALKHPNWSMGAKITIDSATMMNKGL EVIEAHWLFDIPYEQIDVVLHKESIIHSMVEFHDKSVIAQLGTPDMRVPIQYALTYPD RLPLPDAKRLELWEIGSLHFEKADFDRFRCLQFAFESGKIGGTMPTVLNAANEVAVAA FLAGKIPFLAIEDCIEKALTRHQLLKKPSLADIQEVDKDTRGYVNSILT*" /label="dxr CDS" gene 1537242..1538393 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /label="dxr gene" CDS 1538400..1539668 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /EC_number="3.4.24.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inner membrane zinc metalloprotease required forthe extracytoplasmic stress response mediated by sigma(W)" /protein_id="NP_389538.1" /db_xref="EnsemblGenomes-Gn:BSU16560" /db_xref="EnsemblGenomes-Tr:CAB13529" /db_xref="GOA:O31754" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR004387" /db_xref="InterPro:IPR008915" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG13410" /db_xref="UniProtKB/Swiss-Prot:O31754" /translation="MFVNTVIAFIIIFGTLVFFHELGHLLLAQRAGILCREFAIGFGP KIFSFKKNETVYTIRLLPVGGFVRMAGEDPEMIEVKPGYTVGLLFNKEDQVEKVIINQ KEKYPDALVIEVETADLEHDMKITGYEQGKEDELSSFTVSETSFFIVDGEEVQIAPYN RQFGSKPVWQRIKAIAAGPIMNFILAYVILVMLGLIQGVPSNEPMLGQLTDNGRAAEA GLKEGDYIQSINGEKMRSWTDIVSAVKENPEKEMDVAVKRDNKTLHISVTPEAVKDEN KKTIGRFGSYAPTEKGVLSAVAYGATSTVDVTKAILTNLSKLVTGQFKLDMLSGPVGI YDMTDQVAKTGIVNLFQFAAFLSINLGIVNLLPIPALDGGRLLFLFIEAIRGKPINRE KEAFVVFIGVAFLMLLMLVVTWNDIQRLFL*" /label="rasP CDS" gene 1538400..1539668 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /label="rasP gene" CDS 1539701..1541395 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /EC_number="6.1.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16864571, 26886480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl-tRNA synthetase" /protein_id="NP_389539.1" /db_xref="EnsemblGenomes-Gn:BSU16570" /db_xref="EnsemblGenomes-Tr:CAB13530" /db_xref="GOA:O31755" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002316" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004500" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR023717" /db_xref="InterPro:IPR033730" /db_xref="InterPro:IPR036621" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12659" /db_xref="UniProtKB/Swiss-Prot:O31755" /translation="MRQSLTLIPTLREVPADAEAKSHQLLLRAGFIRQNTSGVYSYMP LAYKVIQNIQQIVREEMEKIDAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGR EFALGATHEEVITSLVRDEVKSYKRLPLTLYQIQSKFRDEKRPRFGLLRGREFIMKDA YSFHASAESLDETYQKMYEAYSNIFARCGINVRPVIADSGAMGGKDTHEFMALSAIGE DTIAYSDESQYAANIEMAEVLHQEVPSDEEPKALEKVHTPNVKTIEELTAFLQVSAEA CIKSVLFKADDRFVLVLVRGDHEVNDIKVKNLLHAEVVELATHEEVIQQLGTEPGFVG PVGIHQDVEVYADQAVKAMVNAVAGANEGDHHYKNVNVNRDAQIKEFADLRFIKEGDP SPDGKGTIRFAEGIEVGQVFKLGTRYSEAMNATYLDENGRAQPMLMGCYGIGVSRTLS AIAEQHHDEKGLIWPKSVAPYDLHILALNMKNDGQRELAEKLYADLKAEGYEVLYDDR AERAGVKFADSDLIGLPIRITVGKRADEGIVEVKIRQTGESTEISVDELSAFISKQ*" /label="proS CDS" gene 1539701..1541395 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /label="proS gene" S_feature 1541396..1541503 /Source="Nicolas_S_feature" /locus_tag="new_1727025_1727132" /HighExp="G135, G180, G150, C30, Oxctl, H2O2, Paraq, LPh, LBGexp, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S590" CDS 1541504..1545817 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit)" /protein_id="NP_389540.1" /db_xref="EnsemblGenomes-Gn:BSU16580" /db_xref="EnsemblGenomes-Tr:CAB13531" /db_xref="GOA:P13267" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006308" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR024754" /db_xref="InterPro:IPR028112" /db_xref="InterPro:IPR029460" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG10263" /db_xref="UniProtKB/Swiss-Prot:P13267" /translation="MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASK SWHFHFQFKSLLPFQIYDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCI EELQGISPPIISLLNQQKPKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPD LQLDAEIFVSEQEVQKFREQKLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQ IKDNEEIRTLDSIMDEERRITVQGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFA REKEDAALMKSLKKGMWVKARGSIQNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKR VELHLHSPMSQMDAVTGIGKLVEQAKKWGHEAIALTDHAVVQSFPDAYSAAKKHGIKM IYGMEANLVDDGVPIAYNAAHRLLEEETYVVFDVETTGLSAVYDTIIELAAVKVKGGE IIDKFEAFANPHRPLSATIIELTGITDDMLQDAPDVVDVIRDFREWIGDDILVAHNAS FDMGFLNVAYKKLLEVEKAKNPVIDTLELGRFLYPEFKNHRLNTLCKKFDIELTQHHR AIYDTEATAYLLLKMLKDAAEKGIQYHDELNENMGQSNAYQRSRPYHATLLAVNSTGL KNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIGSACDRGEVFEGMMQKSPEEVED IASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANITKLGEKLNKPVVATGNVHYL NDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEAFSFLGEEKAKEIVVTNTQ KVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGEELPEIVEARIEKELKS IIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEITEVNPLPPHYVCPE CQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFKGDKVPDIDLNFS GEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLHMRGAEIDRLV QGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDFHSIHDNLL KLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIGCKTGTL GIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELSEVIG CRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKIKY MFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNS IPGLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSL F*" /label="polC CDS" gene 1541504..1545817 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /label="polC gene" S_feature 1545818..1545882 /Source="Nicolas_S_feature" /locus_tag="new_1731447_1731511" /HighExp="C30, G180, G135, Oxctl, G150, H2O2, Paraq, Cold, LBGstat, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S591" misc_RNA 1545828..1546045 /gene="surG" /locus_tag="BSU_misc_RNA_71" /product="small RNAs controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surG RNA" gene 1545828..1546045 /gene="surG" /locus_tag="BSU_misc_RNA_71" /label="surG gene" promotor_-35 1545854..1545860 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-35" promotor_-10 1545875..1545886 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-10" S_feature 1545884..1545951 /Source="Nicolas_S_feature" /locus_tag="new_1731513_1731580" /HighExp="S7, S5, S4, S8, S6, S3, G180, C30, T5.0H, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S592" upshifts 1545884 /Source="Nicolas_upshifts" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="upshifts" promotor_-35 1545934..1545940 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-35" S_feature 1545953..1546146 /Source="Nicolas_S_feature" /locus_tag="new_1731582_1731775" /HighExp="LoTm, Cold, HPh, G180, Paraq, Oxctl, T-5.40H, BMM, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S593" upshifts 1545953 /Source="Nicolas_upshifts" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="upshifts" promotor_-10 1545954..1545973 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-10" CDS 1546147..1546617 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15257761, 16014871, 19150615, 20188109, 21529161; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome maturation factor" /protein_id="NP_389541.1" /db_xref="EnsemblGenomes-Gn:BSU16590" /db_xref="EnsemblGenomes-Tr:CAB13532" /db_xref="GOA:P32726" /db_xref="InterPro:IPR003728" /db_xref="InterPro:IPR028989" /db_xref="InterPro:IPR028998" /db_xref="InterPro:IPR035956" /db_xref="InterPro:IPR036847" /db_xref="SubtiList:BG10264" /db_xref="UniProtKB/Swiss-Prot:P32726" /translation="MSKKVTDTVQEMAQPIVDSLQLELVDIEFVKEGQSWFLRVFIDS DDGVDIEECAKVSEALSEKLDEADPISQNYFLEVSSPGAERPLKKKADFEKSLGKNVY IKTYEPIDGVKVFEGELAEFDGQTVTVEITIKTRKKRINIPYEKIANARLAVTF*" /label="rimP CDS" gene 1546147..1546617 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /label="rimP gene" downshifts complement(1546468) /Source="Nicolas_upshifts" /id="D898" /incds=1 /nref=3 /ntot=136 /MaxReadThrough="2.08299" /MaxDrop="3.17419" /score="-8.18111474" /energy="-9.2" /TU="NA" /idTUdmin="U1333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1546652..1547767 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15978071, 16707701, 16946247, 27571753, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15978071, 16707701, 16946247, 27571753, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="transcription translation coupling factor involved in Rho-dependent transcription termination" /protein_id="NP_389542.1" /db_xref="EnsemblGenomes-Gn:BSU16600" /db_xref="EnsemblGenomes-Tr:CAB13533" /db_xref="GOA:P32727" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR010213" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013735" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR025249" /db_xref="InterPro:IPR030842" /db_xref="InterPro:IPR036555" /db_xref="PDB:2MT4" /db_xref="SubtiList:BG10265" /db_xref="UniProtKB/Swiss-Prot:P32727" /translation="MSSELLDALTILEKEKGISKEIIIEAIEAALISAYKRNFNQAQN VRVDLNRETGSIRVFARKDVVDEVYDQRLEISIEEAQGIHPEYMVGDVVEIEVTPKDF GRIAAQTAKQVVTQRVREAERGVIYSEFIDREEDIMTGIVQRLDNKFIYVSLGKIEAL LPVNEQMPNESYKPHDRIKVYITKVEKTTKGPQIYVSRTHPGLLKRLFEIEVPEIYDG TVELKSVAREAGDRSKISVRTDDPDVDPVGSCVGPKGQRVQAIVNELKGEKIDIVNWS SDPVEFVANALSPSKVLDVIVNEEEKATTVIVPDYQLSLAIGKRGQNARLAAKLTGWK IDIKSETDARELGIYPRELEEDDEPLFTEPETAESDE*" /label="nusA CDS" gene 1546652..1547767 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /label="nusA gene" promotor_no_box complement(1546714..1546814) /Source="Nicolas_upshift_promotors" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1546754) /Source="Nicolas_upshifts" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1547781..1548056 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11679764, 12682299, 26771646, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular ruler co-factor for RNA; new fold" /protein_id="NP_389543.1" /db_xref="EnsemblGenomes-Gn:BSU16610" /db_xref="EnsemblGenomes-Tr:CAB13534" /db_xref="InterPro:IPR007393" /db_xref="InterPro:IPR035931" /db_xref="SubtiList:BG10266" /db_xref="UniProtKB/Swiss-Prot:P32728" /translation="MNKHKKIPLRKCVVTGEMKPKKELIRVVRSKEGEISVDPTGKKN GRGAYLTLDKECILAAKKKNTLQNQFQSQIDDQIFDELLELAEKVKK*" /label="rulR CDS" gene 1547781..1548056 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /label="rulR gene" CDS 1548058..1548360 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15130481, 15361074, 22355167, 26522935, 26771646" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130481, 15361074, 22355167, 26522935, 26771646; Product type f: factor" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein" /protein_id="NP_389544.1" /db_xref="EnsemblGenomes-Gn:BSU16620" /db_xref="EnsemblGenomes-Tr:CAB13535" /db_xref="GOA:P32729" /db_xref="InterPro:IPR004037" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7Q" /db_xref="SubtiList:BG10267" /db_xref="UniProtKB/Swiss-Prot:P32729" /translation="MSGMEWFPLLGLANRARKVVSGEDLVIKEIRNARAKLVLLTEDA SSNTAKKVTDKCNYYKVPYKKVESRAVLGRSIGKEARVVVAVTDQGFANKLISLLD*" /label="rulQ CDS" gene 1548058..1548360 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /label="rulQ gene" CDS 1548380..1550530 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1426242, 9588797, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1426242, 9588797, 12682299, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-2" /protein_id="NP_389545.1" /db_xref="EnsemblGenomes-Gn:BSU16630" /db_xref="EnsemblGenomes-Tr:CAB13536" /db_xref="GOA:P17889" /db_xref="InterPro:IPR000178" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006847" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR015760" /db_xref="InterPro:IPR023115" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036925" /db_xref="SubtiList:BG10268" /db_xref="UniProtKB/Swiss-Prot:P17889" /translation="MAKMRVYEYAKALNVSSKEILTALKNMDLEVNNHMAMLEEKAIK KLDAKYKKGGAAAKSQKPAETNKNKQPQGVNQQSAGNQPNKIRDGKKNDVQNNQFNKN KKNNNNKKNKRNNNNNKNQHQQKPVKPKKELPEKITFSGTLTVGALAEELGKEPSELI KKLMLLGVMATINQELDKDTIELIASEYGVETEEVIVLEETELEKYEEPDNEEDLEIR PPVVTIMGHVDHGKTTLLDSIRKTKVVEGEAGGITQHIGAYQIEENGKKITFLDTPGH AAFTTMRARGAEVTDITILVVAADDGVMPQTVEAINHAKAAEVPIIVAVNKIDKESAN PDRVMQELTEYGLVPEAWGGETIFVPLSALTGKGIDELVEMILLVSEVEELKANPNRQ AKGTVIEAELDKGRGSVATLLVQTGTLHVGDPIVVGNTFGRVRAMVNDIGRRVKTAGP STPVEITGLNDVPQAGDQFLVFKDEKTARSVGEARASKQLEEQRSDKAKLSLDDLFEQ IKQGDVKDINLIVKADVQGSAEALTAALQKIEVEGVKVKIIHTGVGAITESDIILASA SNAIVIGFNVRPDGNAKSTAEAENVDIRLHRIIYKVIDEIEAAMKGMLDPEYEEKVIG QVEVRQTFKVSKIGTIAGGYVTEGTITRDSGLRLIRDGVVIFEGEVDVLKRFKDDVKE VSQGYECGITIKKYNDIREGDILEAFVMQEIERT*" /label="infB CDS" gene 1548380..1550530 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /label="infB gene" promotor_-35 1550425..1550431 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1550440 /Source="Nicolas_upshifts" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1550446..1550464 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1550527..1550805 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of conserved protein" /db_xref="EnsemblGenomes-Gn:BSU16640" /db_xref="EnsemblGenomes-Tr:CAB13537" /db_xref="InterPro:IPR007546" /db_xref="InterPro:IPR036746" /db_xref="PSEUDO:CAB13537.1" /db_xref="SubtiList:BG10269" /db_xref="UniProtKB/Swiss-Prot:P32730" /translation="MIGFAECECIIYDAGSLKEKRAVLKRILTRVQNKFNVSISEIGY QDTWQRTSFGIAAVSSSRVQTEKELQRVLAFIDSFPEIERTITRTEWF*" /label="ylxP CDS" gene 1550527..1550805 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /pseudo /label="ylxP gene" CDS 1550822..1551175 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12628255, 15185964, 17996707, 21102555, 21529161, 23293003, 23611982, 24671761, 25904134, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="pre-ribosomal (17S) RNA binding factor A" /protein_id="NP_389547.1" /db_xref="EnsemblGenomes-Gn:BSU16650" /db_xref="EnsemblGenomes-Tr:CAB13538" /db_xref="GOA:P32731" /db_xref="InterPro:IPR000238" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020053" /db_xref="InterPro:IPR023799" /db_xref="SubtiList:BG10270" /db_xref="UniProtKB/Swiss-Prot:P32731" /translation="MSMRANRVGEQMKKELGDIISRKLKDPRIGFLTVTDVRVSGDLQ IAKVYISVLGDEKKREEALKGLAKAKGFIRSEIGSRIRLRKTPEIEFEFDESIDYGNR IETLIHELHSEKPSE*" /label="rbfA CDS" gene 1550822..1551175 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /label="rbfA gene" downshifts 1551166 /Source="Nicolas_upshifts" /id="D899" /incds=0 /nref=9 /ntot=130 /MaxReadThrough="6.97196" /MaxDrop="5.80207" /score="-3.06560848" /energy="-13.8" /TU="U1331,U1332,U1334" /idTUdmin="U1331" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" CDS 1551257..1552186 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /EC_number="5.4.99.25" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7489483, 15987897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine 55 synthase" /protein_id="NP_389548.1" /db_xref="EnsemblGenomes-Gn:BSU16660" /db_xref="EnsemblGenomes-Tr:CAB13539" /db_xref="GOA:P32732" /db_xref="InterPro:IPR002501" /db_xref="InterPro:IPR014780" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR032819" /db_xref="SubtiList:BG10271" /db_xref="UniProtKB/Swiss-Prot:P32732" /translation="MVNGVLLLHKPVGMTSHDCVMKIRKLLKTKKVGHTGTLDPEVSG VLPICVGRATKIVEYLTEKSKTYDAEITLGFSTTTEDQTGETVETKPVNHDIDKADVE KVLNSLKGKQEQIPPMYSAVKVNGKKLYEYARAGIEVERPKRMITIEDIALTTEIKHH GETASFRFTVTCSKGTYVRTLAVMIGEKLGYPAHMSHLIRTASGDFSLDECFTFDELE AQAQSGTVEEHTVPIERALNHLPKWIISDTLAKKVENGALLETPEQFSEMTSGDRIAV FTESGTCLAIYFPHPAKKGLLKPAKVLMQKSEQ*" /label="truB CDS" gene 1551257..1552186 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /label="truB gene" promotor_-35 1551971..1551978 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1551992..1552011 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1552001 /Source="Nicolas_upshifts" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1552205..1553155 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /EC_number="2.7.1.26" /EC_number="2.7.7.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9473052, 10206712, 12456892, 15668000, 18156273, 21866869" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9473052, 10206712, 12456892, 15668000, 18156273, 21866869; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="bifunctional riboflavin kinase FAD synthase" /protein_id="NP_389549.1" /db_xref="EnsemblGenomes-Gn:BSU16670" /db_xref="EnsemblGenomes-Tr:CAB13540" /db_xref="GOA:P54575" /db_xref="InterPro:IPR002606" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015864" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11495" /db_xref="UniProtKB/Swiss-Prot:P54575" /translation="MKTIHITHPHHLIKEEQAKSVMALGYFDGVHLGHQKVIGTAKQI AEEKGLTLAVMTFHPHPSHVLGRDKEPKDLITPLEDKINQIEQLGTEVLYVVKFNEVF ASLSPKQFIDQYIIGLNVQHAVAGFDFTYGKYGKGTMKTMPDDLDGKAGCTMVEKLTE QDKKISSSYIRTALQNGDVELANVLLGQPYFIKGIVIHGDKRGRTIGFPTANVGLNNS YIVPPTGVYAVKAEVNGEVYNGVCNIGYKPTFYEKRPEQPSIEVNLFDFNQEVYGAAI KIEWYKRIRSERKFNGIKELTEQIEKDKQEAIRYFSNLRK*" /label="ribC CDS" gene 1552205..1553155 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /label="ribC gene" promotor_-35 1553188..1553194 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1553195..1553311 /Source="Nicolas_S_feature" /locus_tag="new_1738824_1738940" /HighExp="SMM, GM 15, Salt, T-4.40H, GM 45, T-5.40H, GM 60, MG 45, LPhT, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S594" upshifts 1553195 /Source="Nicolas_upshifts" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1553209..1553228 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1553312..1553581 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15627386, 8825778, 20418391, 22720735, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15627386, 8825778, 20418391, 22720735, 23611891; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S15 (BS18)" /protein_id="NP_389550.1" /db_xref="EnsemblGenomes-Gn:BSU16680" /db_xref="EnsemblGenomes-Tr:CAB13541" /db_xref="GOA:P21473" /db_xref="InterPro:IPR000589" /db_xref="InterPro:IPR005290" /db_xref="InterPro:IPR009068" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19010" /db_xref="UniProtKB/Swiss-Prot:P21473" /translation="MAITQERKNQLINEFKTHESDTGSPEVQIAILTDSINNLNEHLR THKKDHHSRRGLLKMVGKRRNLLTYLRNKDVTRYRELINKLGLRR*" /label="rpsO CDS" gene 1553312..1553581 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /label="rpsO gene" downshifts 1553564 /Source="Nicolas_upshifts" /id="D900" /incds=0 /nref=30 /ntot=154 /MaxReadThrough="8.65904" /MaxDrop="5.6648" /score="29.9198852" /energy="-10.2" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1331" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" S_feature 1553609..1553694 /Source="Nicolas_S_feature" /locus_tag="new_1739238_1739323" /HighExp="Cold, LoTm, Oxctl, G180, H2O2, G150, dia15, Paraq, LPh, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S595" promotor_-35 1553675..1553678 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1553694..1553713 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1553696 /Source="Nicolas_upshifts" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1553754..1555871 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /EC_number="2.7.7.8" /EC_number="3.1.13.1" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polynucleotide phosphorylase (PNPase)" /protein_id="NP_389551.1" /db_xref="EnsemblGenomes-Gn:BSU16690" /db_xref="EnsemblGenomes-Tr:CAB13542" /db_xref="GOA:P50849" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR012162" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR015848" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="InterPro:IPR036456" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG11491" /db_xref="UniProtKB/Swiss-Prot:P50849" /translation="MGQEKHVFTIDWAGRTLTVETGQLAKQANGAVMIRYGDTAVLST ATASKEPKPLDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAVLASRLIDRPIRPL FADGFRNEVQVISIVMSVDQNCSSEMAAMFGSSLALSVSDIPFEGPIAGVTVGRIDDQ FIINPTVDQLEKSDINLVVAGTKDAINMVEAGADEVPEEIMLEAIMFGHEEIKRLIAF QEEIVAAVGKEKSEIKLFEIDEELNEKVKALAEEDLLKAIQVHEKHAREDAINEVKNA VVAKFEDEEHDEDTIKQVKQILSKLVKNEVRRLITEEKVRPDGRGVDQIRPLSSEVGL LPRTHGSGLFTRGQTQALSVCTLGALGDVQILDGLGVEESKRFMHHYNFPQFSVGETG PMRGPGRREIGHGALGERALEPVIPSEKDFPYTVRLVSEVLESNGSTSQASICASTLA MMDAGVPIKAPVAGIAMGLVKSGEHYTVLTDIQGMEDALGDMDFKVAGTEKGVTALQM DIKIEGLSREILEEALQQAKKGRMEILNSMLATLSESRKELSRYAPKILTMTINPDKI RDVIGPSGKQINKIIEETGVKIDIEQDGTIFISSTDESGNQKAKKIIEDLVREVEVGQ LYLGKVKRIEKFGAFVEIFSGKDGLVHISELALERVGKVEDVVKIGDEILVKVTEIDK QGRVNLSRKAVLREEKEKEEQQS*" /label="pnpA CDS" gene 1553754..1555871 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /label="pnpA gene" downshifts 1555654 /Source="Nicolas_upshifts" /id="D901" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.05841" /MaxDrop="3.82025" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336,U1337" /idTUdmin="U1337" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 1555855 /Source="Nicolas_upshifts" /id="D902" /incds=0 /nref=192 /ntot=270 /MaxReadThrough="5.61214" /MaxDrop="6.82185" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1337" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature 1555900..1555988 /Source="Nicolas_S_feature" /locus_tag="new_1741529_1741617" /HighExp="G135, G180, G150, H2O2, Oxctl, LBGexp, Paraq, LoTm, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S596" CDS 1555989..1556948 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14679227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar deacetylase" /protein_id="NP_389552.1" /db_xref="EnsemblGenomes-Gn:BSU16700" /db_xref="EnsemblGenomes-Tr:CAB13543" /db_xref="GOA:P50850" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR010916" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014228" /db_xref="SubtiList:BG11492" /db_xref="UniProtKB/Swiss-Prot:P50850" /translation="MYKKFVPFAVFLFLFFVSFEMMENPHALDYIGAMKKDTVTVTAS KDPLYEELLQKAPEYEVKPQNARIDKVWKSIPGYNGLKVNIEQSYKKMKQHGKFREKD LVYSQVKPSVHLESLQPEPIYKGNPDKPMVAFLINVAWGNEYLEKMLPILQKHQVKAT FFLEGNWVRNNVQLAKKIAKDGHEIGNHSYNHPDMSKLTTGRISEQLDKTNEQIEQTI GVKPKWFAPPSGSFRKAVIDIAAEKQMGTVMWTVDTIDWQKPAPSVLQTRVLSKIHNG AMILMHPTDPTAESLEALITQIKDKGYALGTVTELMDETRLLK*" /label="ylxY CDS" gene 1555989..1556948 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /label="ylxY gene" promotor_-10 complement(1556057..1556065) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1556060) /Source="Nicolas_upshifts" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1556079..1556086) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1556552..1556557 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1556573..1556591 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1556578 /Source="Nicolas_upshifts" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1556988..1558217 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10666719, 10974125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666719, 10974125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="specific processing protease" /protein_id="NP_389553.2" /db_xref="EnsemblGenomes-Gn:BSU16710" /db_xref="EnsemblGenomes-Tr:CAB13544" /db_xref="GOA:Q04805" /db_xref="InterPro:IPR001431" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG10779" /db_xref="UniProtKB/Swiss-Prot:Q04805" /translation="MIKRYTCQNGVRIVLENNPTVRSVAIGVWIGTGSRHETPEINGI SHFLEHMFFKGTSTKSAREIAESFDRIGGQVNAFTSKEYTCYYAKVLDEHANYALDVL ADMFFHSTFDENELKKEKNVVYEEIKMYEDAPDDIVHDLLSKATYGNHSLGYPILGTE ETLASFNGDSLRQYMHDYYTPDRVVISVAGNISDSFIKDVEKWFGSYEAKGKATGLEK PEFHTEKLTRKKETEQAHLCLGFKGLEVGHERIYDLIVLNNVLGGSMSSRLFQDVRED KGLAYSVYSYHSSYEDSGMLTIYGGTGANQLQQLSETIQETLATLKRDGITSKELENS KEQMKGSLMLSLESTNSKMSRNGKNELLLGKHKTLDEIINELNAVNLERVNGLARQLF TEDYALALISPSGNMPS*" /label="mlpA CDS" gene 1556988..1558217 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /label="mlpA gene" downshifts 1558206 /Source="Nicolas_upshifts" /id="D903" /incds=0 /nref=140 /ntot=219 /MaxReadThrough="1.31218" /MaxDrop="4.84427" /score="15.1952611" /energy="-12.6" /TU="NA" /idTUdmin="U1336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1558246..1558251 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1558261 /Source="Nicolas_upshifts" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1558267..1558285 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1558295..1558552 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /experiment="publication(s) with functional evidences, PMID:23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="PRC barrel protein involved in sporulation" /protein_id="NP_389554.1" /db_xref="EnsemblGenomes-Gn:BSU16720" /db_xref="EnsemblGenomes-Tr:CAB13545" /db_xref="GOA:Q04811" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG10780" /db_xref="UniProtKB/Swiss-Prot:Q04811" /translation="MRLSELSGKEIVDIKRAERLGVLGQTDLEINEQDGQITALLIPT VKWFGLRKQGHDIRVPWHHIQKIGSDMIILDVPEEMPPRQE*" /label="ymxH CDS" gene 1558295..1558552 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /label="ymxH gene" S_feature 1558553..1558607 /Source="Nicolas_S_feature" /locus_tag="new_1744182_1744236" /HighExp="S4, S3, S5, S6, S8, S7, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S597" downshifts 1558580 /Source="Nicolas_upshifts" /id="D904" /incds=0 /nref=41 /ntot=56 /MaxReadThrough="0.534319999999999" /MaxDrop="6.36032" /score="29.434739" /energy="-11.7" /TU="NA" /idTUdmin="U1340" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1558649..1558658 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-35" S_feature 1558668..1558737 /Source="Nicolas_S_feature" /locus_tag="new_1744297_1744366" /HighExp="S6, S8, S7, BT, B36, S5, G/S, Pyr, B60, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S598" upshifts 1558668 /Source="Nicolas_upshifts" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="upshifts" promotor_-10 1558672..1558691 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-10" CDS 1558738..1559631 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /EC_number="1.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit A" /protein_id="NP_389555.1" /db_xref="EnsemblGenomes-Gn:BSU16730" /db_xref="EnsemblGenomes-Tr:CAB13546" /db_xref="GOA:Q04809" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR014215" /db_xref="InterPro:IPR031629" /db_xref="InterPro:IPR036291" /db_xref="PDB:2RIR" /db_xref="SubtiList:BG10781" /db_xref="UniProtKB/Swiss-Prot:Q04809" /translation="MLTGLKIAVIGGDARQLEIIRKLTEQQADIYLVGFDQLDHGFTG AVKCNIDEIPFQQIDSIILPVSATTGEGVVSTVFSNEEVVLKQDHLDRTPAHCVIFSG ISNAYLENIAAQAKRKLVKLFERDDIAIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVL GLGRTGMTIARTFAALGANVKVGARSSAHLARITEMGLVPFHTDELKEHVKDIDICIN TIPSMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGLPGIVAPKTA GQILANVLSKLLAEIQAEEGK*" /label="spoVFA CDS" gene 1558738..1559631 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /label="spoVFA gene" CDS 1559634..1560236 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit B" /protein_id="NP_389556.1" /db_xref="EnsemblGenomes-Gn:BSU16740" /db_xref="EnsemblGenomes-Tr:CAB13547" /db_xref="GOA:Q04810" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR014214" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG10782" /db_xref="UniProtKB/Swiss-Prot:Q04810" /translation="MSSLKGKRIGFGLTGSHCTYEAVFPQIEELVNEGAEVRPVVTFN VKSTNTRFGEGAEWVKKIEDLTGYEAIDSIVKAEPLGPKLPLDCMVIAPLTGNSMSKL ANAMTDSPVLMAAKATIRNNRPVVLGISTNDALGLNGTNLMRLMSTKNIFFIPFGQDD PFKKPNSMVAKMDLLPQTIEKALMHQQLQPILVENYQGND*" /label="spoVFB CDS" gene 1559634..1560236 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /label="spoVFB gene" misc_feature 1560290..1560309 /Source="Nicolas_upshift_promotors" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1560290..1560361 /Source="Nicolas_S_feature" /locus_tag="new_1745919_1745990" /HighExp="S6, S7, S8, C90, S5, BT, MG 45, MG 5, SMM, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S599" upshifts 1560290 /Source="Nicolas_upshifts" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1560362..1561402 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /EC_number="1.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 12682299, 25355936, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 12682299, 25355936, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate-semialdehyde dehydrogenase" /protein_id="NP_389557.1" /db_xref="EnsemblGenomes-Gn:BSU16750" /db_xref="EnsemblGenomes-Tr:CAB13548" /db_xref="GOA:Q04797" /db_xref="InterPro:IPR000319" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR005986" /db_xref="InterPro:IPR012080" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10783" /db_xref="UniProtKB/Swiss-Prot:Q04797" /translation="MGRGLHVAVVGATGAVGQQMLKTLEDRNFEMDTLTLLSSKRSAG TKVTFKGQELTVQEASPESFEGVNIALFSAGGSVSQALAPEAVKRGAIVIDNTSAFRM DENTPLVVPEVNEADLHEHNGIIANPNCSTIQMVAALEPIRKAYGLNKVIVSTYQAVS GAGNEAVKELYSQTQAILNKEEIEPEIMPVKGDKKHYQIAFNAIPQIDKFQDNGYTFE EMKMINETKKIMHMPDLQVAATCVRLPIQTGHSESVYIEIDRDDATVEDIKNLLKEAP GVTLQDDPSQQLYPMPADAVGKNDVFVGRIRKDLDRANGFHLWVVSDNLLKGAAWNSV QIAESLKKLNLV*" /label="asd CDS" gene 1560362..1561402 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /label="asd gene" S_feature 1561403..1561493 /Source="Nicolas_S_feature" /locus_tag="new_1747032_1747122" /HighExp="S7, S6, S8, LBGtran, GM 120, dia15, Heat, LBGstat, GM 90, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S600" CDS 1561494..1562708 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1906928, 8098035" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906928, 8098035; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase I (alpha and beta subunits)" /protein_id="NP_389558.2" /db_xref="EnsemblGenomes-Gn:BSU16760" /db_xref="EnsemblGenomes-Tr:CAB13549" /db_xref="GOA:Q04795" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10784" /db_xref="UniProtKB/Swiss-Prot:Q04795" /translation="MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMG RKGDPYATDSLLGLLYGDQSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTG AQAGFLTNDQHTNAKIIEMKPERLFSVLANHDAVVVAGFQGATEKGDTTTIGRGGSDT SAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISP RAVEIAMQAKVPIRVRSTYSNDKGTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKV PAKIGQYNVQTEVFKAMANAGISVDFFNITPSEIVYTVAGNKTETAQRILMDMGYDPM VTRNCAKVSAVGAGIMGVPGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPA VNALHEVFELSK*" /label="dapG CDS" gene 1561494..1562708 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /label="dapG gene" CDS 1562739..1563611 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /EC_number="4.3.3.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 9298659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 9298659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-tetrahydrodipicolinate synthase" /protein_id="NP_389559.1" /db_xref="EnsemblGenomes-Gn:BSU16770" /db_xref="EnsemblGenomes-Tr:CAB13550" /db_xref="GOA:Q04796" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR005263" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020624" /db_xref="InterPro:IPR020625" /db_xref="SubtiList:BG10785" /db_xref="UniProtKB/Swiss-Prot:Q04796" /translation="MNFGNVSTAMITPFDNKGNVDFQKLSTLIDYLLKNGTDSLVVAG TTGESPTLSTEEKIALFEYTVKEVNGRVPVIAGTGSNNTKDSIKLTKKAEEAGVDAVM LVTPYYNKPSQEGMYQHFKAIAAETSLPVMLYNVPGRTVASLAPETTIRLAADIPNVV AIKEASGDLEAITKIIAETPEDFYVYSGDDALTLPILSVGGRGVVSVASHIAGTDMQQ MIKNYTNGQTANAALIHQKLLPIMKELFKAPNPAPVKTALQLRGLDVGSVRLPLVPLT EDERLSLSSTISEL*" /label="dapA CDS" gene 1562739..1563611 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /label="dapA gene" S_feature complement(1563082..1564266) /Source="Nicolas_S_feature" /locus_tag="new_1748711_1749895_c" /HighExp="S8, S6, S4, S5, S7, S3, LoTm, T5.0H, BT, C30" /AntisenseName="dapA" /AntisenseCor="0.13444126275526899" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S601" downshifts 1563618 /Source="Nicolas_upshifts" /id="D905" /incds=0 /nref=17 /ntot=99 /MaxReadThrough="6.0497" /MaxDrop="5.05122" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1341" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1563711..1563714 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1563728 /Source="Nicolas_upshifts" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1563730..1563749 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1563789..1565456 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual activity 5' exo-and endoribonuclease J2" /protein_id="NP_389560.2" /db_xref="EnsemblGenomes-Gn:BSU16780" /db_xref="EnsemblGenomes-Tr:CAB13551" /db_xref="GOA:O31760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13422" /db_xref="UniProtKB/Swiss-Prot:O31760" /translation="MKKKNTENVRIIALGGVGEIGKNLYVIEIDSDIFVVDAGLMHPE NEMLGIDVVIPDISYLIERADRVKAIFLTHGHDENIGGVFYLLNKLSVPVYGTKLTLA LLREKLKQYGHNRKTDLREIHSKSVITFESTKVSFFRTIHSIPDSVGVSFKTSLGSIV CTGDFKFDQTPALNQTCDIGEIAKIGNSGVLALLSDSANAERPGYTPSEAAVSGEISD ALYNSQNRVIIAVFASNINRIQQVIHAAAQNGRKIAVAGKNLQSVLQLARKLGYIEAD DELFISVQDVKKYPKREVAIITAGSQGEPLAALTRMANKAHKQLNIEEGDTVVIASTP IPGQELIYSKTVDLLARAGAQVIFAQKRVHVSGHGSQEELKLMINLLKPKYLIPVNGE YRMQKAHSKIAEETGMKRSDIFLIEKGDVVEFRGQNVKIGDKVPYGNILIDGLGVGDI GNIVLRDRRLLSQDGILIVVITLDKQKKHLVSGPEIITRGFVYVRESEGLIVQATELV RSIVTEATETSNVEWSTLKQAMRDALNQFLYEKTKRKPMIIPIIMEV*" /label="rnjB CDS" gene 1563789..1565456 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /label="rnjB gene" promotor_-10 complement(1564253..1564271) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1564270) /Source="Nicolas_upshifts" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1564287..1564292) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1565444 /Source="Nicolas_upshifts" /id="D906" /incds=0 /nref=227 /ntot=263 /MaxReadThrough="4.0072" /MaxDrop="6.75416" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1565511..1565517 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-35" promotor_-10 1565531..1565542 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-10" upshifts 1565532 /Source="Nicolas_upshifts" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="upshifts" CDS 1565572..1566309 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10455123, 15189290, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455123, 15189290, 23927687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein export-enhancing protease (spore outgrowth)" /protein_id="NP_389561.3" /db_xref="EnsemblGenomes-Gn:BSU16790" /db_xref="EnsemblGenomes-Tr:CAB13552" /db_xref="GOA:Q99171" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11055" /db_xref="UniProtKB/Swiss-Prot:Q99171" /translation="MDHRMENTEEERPEKNDAKDSIMNKIQQLGETTLPQLPQDTNIH CLTIIGQIEGHVQLPPQNKTTKYEHVIPQIVAIEQNPKIEGLLIILNTVGGDVEAGLA IAEMLASLSKPTVSIVLGGGHSIGVPIAVSCDYSYIAETATMTIHPVRLTGLVIGVPQ TFEYLDKMQERVVKFVTSHSNITEEKFKELMFSKGNLTRDIGTNVVGKDAVKYGLIDH AGGVGQAINKLNELIDEARKEEGRMIQ*" /label="tepA CDS" gene 1565572..1566309 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /label="tepA gene" CDS 1566306..1566518 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23927687; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of TepA activity (spore outgrowth)" /protein_id="YP_003097729.1" /db_xref="EnsemblGenomes-Gn:BSU16799" /db_xref="EnsemblGenomes-Tr:CAX52620" /db_xref="InterPro:IPR025619" /db_xref="UniProtKB/Swiss-Prot:C0H413" /translation="MILYTVMPQEIVFAEQNQETSAHEQIEYKGVPLLVEMKGNEAEV IQIMSTNPMHFLHPDISPGQKLKLNV*" /label="tepJ CDS" gene 1566306..1566518 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /label="tepJ gene" misc_feature 1566546..1566565 /Source="Nicolas_upshift_promotors" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1566560 /Source="Nicolas_upshifts" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="upshifts" CDS 1566649..1569012 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11062134, 11778051, 12618465, 16430687, 17139259, 17322320, 18160039, 24297254, 24769697, 26452092; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore DNA directional translocase (motor ATPase)" /protein_id="NP_389562.3" /db_xref="EnsemblGenomes-Gn:BSU16800" /db_xref="EnsemblGenomes-Tr:CAB13553" /db_xref="GOA:P21458" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10763" /db_xref="UniProtKB/Swiss-Prot:P21458" /translation="MAKKKRKSRKKQAKQLNIKYELNGLLCIAISIIAILQLGVVGQT FIYLFRFFAGEWFILCLLGLLVLGVSLFWKKKTPSLLTRRKAGLYCIIASILLLSHVQ LFKNLTHKGSIESASVVRNTWELFLMDMNGSSASPDLGGGMIGALLFAASHFLFASTG SQIMAIVMILIGMILVTGRSLQETLKKWMSPIGRFIKEQWLAFIDDMKSFKSNMQSSK KTKAPSKKQKPARKKQQMEPEPPDEEGDYETVSPLIHSEPIISSFSDRNEEEESPVIE KRAEPVSKPLQDIQPETGDQETVSAPPMTFTELENKDYEMPSLDLLADPKHTGQQADK KNIYENARKLERTFQSFGVKAKVTQVHLGPAVTKYEVYPDVGVKVSKIVNLSDDLALA LAAKDIRIEAPIPGKSAIGIEVPNAEVAMVSLKEVLESKLNDRPDAKLLIGLGRNISG EAVLAELNKMPHLLVAGATGSGKSVCVNGIITSILMRAKPHEVKMMMIDPKMVELNVY NGIPHLLAPVVTDPKKASQALKKVVNEMERRYELFSHTGTRNIEGYNDYIKRANNEEG AKQPELPYIVVIVDELADLMMVASSDVEDSITRLSQMARAAGIHLIIATQRPSVDVIT GVIKANIPSRIAFSVSSQTDSRTILDMGGAEKLLGRGDMLFLPVGANKPVRVQGAFLS DDEVEKVVDHVITQQKAQYQEEMIPEETTETHSEVTDELYDEAVELIVGMQTASVSML QRRFRIGYTRAARLIDAMEERGVVGPYEGSKPREVLLSKEKYDELSS*" /label="spoIIIE CDS" gene 1566649..1569012 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /label="spoIIIE gene" S_feature 1569013..1569113 /Source="Nicolas_S_feature" /locus_tag="new_1754642_1754742" /HighExp="Cold, C30, G135, Lbstat, BC, G180, G150, S8, LoTm, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.109246" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S602" promotor_-35 1569074..1569081 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1569096..1569115 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1569114 /Source="Nicolas_upshifts" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="upshifts" CDS 1569156..1569881 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family,possibly involved in biofilm formation)" /protein_id="NP_389563.1" /db_xref="EnsemblGenomes-Gn:BSU16810" /db_xref="EnsemblGenomes-Tr:CAB13554" /db_xref="GOA:O31761" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13423" /db_xref="UniProtKB/Swiss-Prot:O31761" /translation="MSTKADNRHLYLKVIERIKEDIKNGIYTEKEKLPSEFELSKKLG VSRATLREALRILEEEHVIIRRHGVGTFVHSKPLFLSGIEQLNSVTKMIEQANMTPGT IFLSSQVLMPSEDDTKRFHLAEGQELFYLERVRTADGQPIVYCIDKIPMNILPNSFSH QQESMFDLLEKNSGSVISYAVTDIEPIGYHDTISPVLECDPETALLLLKQTHYDQHDK PVLYSLNYFRADKFRFHVLRKRF*" /label="ymfC CDS" gene 1569156..1569881 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /label="ymfC gene" downshifts 1569868 /Source="Nicolas_upshifts" /id="D907" /incds=0 /nref=135 /ntot=256 /MaxReadThrough="4.863" /MaxDrop="4.01593" /score="16.3235883" /energy="-7.2" /TU="U1346,U1347" /idTUdmin="U1346" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 1569937..1569943 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1569956 /Source="Nicolas_upshifts" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1569958..1569969 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1570020..1571228 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /function="7: Transport and binding proteins" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18502870, 27375568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18502870, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacillibactin exporter" /protein_id="NP_389564.2" /db_xref="EnsemblGenomes-Gn:BSU16825" /db_xref="EnsemblGenomes-Tr:CAB13555" /db_xref="GOA:O31762" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13424" /db_xref="UniProtKB/Swiss-Prot:O31762" /translation="MKNIIALSSVPLVMTLGNSMLIPVLPMMEKKLSVTSFQVSLIIT VYSVVAIICIPIAGYLSDRFGRKKILLPCLLIAGLGGAVAAFASTYMKNPYAMILAGR VLQGIGSAGAAPIVMPFIGDLFKGDDEKVSAGLGDIETANTSGKVLSPILGALLASWY WFVPFWFIPFFCLISFLLVLFLVAKPEEDEDAPAVSEFIKSVKKIFKQDGRWLYTVFI IGCVIMFLLFGVLFYLSDTLENKYAIDGVAKGGLLAIPLLFLSTSSFIAGKKIGKDKG RMKFCVVTGMILLTLSFIALWWNHSFYFLFVFLSFGGIGIGMALPALDALITEGIESE QCGTISSFYNSMRFIGVALGPPVFAALMSNANWIIFILSAFCSIVSLFLVLFTVDAKK SEEEKNLGTV*" /label="bcbE CDS" gene 1570020..1571228 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /label="bcbE gene" downshifts 1571186 /Source="Nicolas_upshifts" /id="D908" /incds=0 /nref=1 /ntot=32 /MaxReadThrough="1.34389" /MaxDrop="3.00655" /score="5.64651968" /energy="-6.7" /TU="NA" /idTUdmin="U1348" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1571297..1571304 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1571317..1571336 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1571339 /Source="Nicolas_upshifts" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" promotor_-35 1571351..1571354 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1571370..1571382 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1571384 /Source="Nicolas_upshifts" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1571408..1572688 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metalloprotease" /protein_id="NP_389566.2" /db_xref="EnsemblGenomes-Gn:BSU16845" /db_xref="EnsemblGenomes-Tr:CAB13557" /db_xref="GOA:O31764" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG13426" /db_xref="UniProtKB/Swiss-Prot:O31764" /translation="MSYVNELKSKHGGLTAHIVKTEKFKTVSLIFKMLAPLTKDQVTK RALLPHVLLRGTKSHPKTAGLRSYLDELYGTSVSADLTKKGERHVITFRLEIPNEKYL KDQTPLLEKGLQLLAELVFSPALEGDAFQSQYVAQEKRTLKQRIQAVYDDKMRYSNLR LIQEMCKNDPYALHVNGEIDDVDDITAEQLYETYQSAIQKDQLDLYVVGDVDSNQVQS AIDKYFKTEERTLGMIENNHADEKVQPKEVIDEEDVKQGKLNIGYRTSITYTDQDYPA LQVFNGLFGGFSHSKLFINVREKASLAYYAASRIESFKGLLMVMSGIEVKNFEQAVSI IAEQFQAMKNGDFSEQDIAQTKAVIRNQVLETIDTAYGLSEFLYQQAAAQVEIPIEDF LANIENVTKEDIIKAGEKIQLDTTYFLKGTEGAS*" /label="ymfF CDS" gene 1571408..1572688 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /label="ymfF gene" CDS 1572685..1573971 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative processing protease" /protein_id="NP_389568.2" /db_xref="EnsemblGenomes-Gn:BSU16860" /db_xref="EnsemblGenomes-Tr:CAB13559" /db_xref="GOA:O31766" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG13428" /db_xref="UniProtKB/Swiss-Prot:O31766" /translation="MIKPIEYEQLQETLYHEKMSNGLDVYVLPKKGFNKTYAVFTTKY GSIDNRFVPLGKNEMVHVPDGIAHFLEHKLFEKADGDVFQDFSKQGASANAFTSFTRT AYLFSSTSNVERNLETLIDFVQDPYFTEKTVEKEKGIIGQEINMYDDNPDWRLYFGVI ENMYKEHPVRIDIAGTVESISHITKDLLYECYETFYHPSNMLLFIVGPVDPEAIISQV RENQGKKPYTDQPEIKREEVKEQEAVFRKEKEIKMNVQGPKCLVGLKSKNPFKLGKEL LKHELSMNLLLEALFGKSSAQYESLYEKGYIDETFSFDFTAEYGFGFAAIGGDTPEPD QLAEDISSMLLRAGELITAEKIELARKKKIGTFLKALNSPEYIANQFTRYAFLDMSLF DVVTVLEQITLEDVQNVIQEEIAADRLTVCKVVPKS*" /label="ymfH CDS" gene 1572685..1573971 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /label="ymfH gene" downshifts 1573821 /Source="Nicolas_upshifts" /id="D909" /incds=1 /nref=10 /ntot=159 /MaxReadThrough="5.673" /MaxDrop="3.16735" /score="1.51160893" /energy="-10.4" /TU="U1349,U1350" /idTUdmin="U1350" /TUdmin="-1256" /isTUend="FALSE" /label="downshifts" S_feature 1573972..1574025 /Source="Nicolas_S_feature" /locus_tag="new_1759601_1759654" /HighExp="Etha, dia15, H2O2, G135, G150, G180, Paraq, LBGexp, Oxctl, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.431, 0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S603" CDS 1574026..1574754 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15066026, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 28787546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="EF-P-5 aminopentanone reductase (EF-P repair enzyme), NADPH-dependent" /protein_id="NP_389569.2" /db_xref="EnsemblGenomes-Gn:BSU16870" /db_xref="EnsemblGenomes-Tr:CAB13560" /db_xref="GOA:O31767" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13429" /db_xref="UniProtKB/Swiss-Prot:O31767" /translation="MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELA EKLSQMFGVNAEILQADLSAQDGADKLTSSIVQPIDAIVLNSGRSHFGLITDVDNATV QEMVQLHVASPYMLTRNLLPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSF VKGLAKELAPSGIRVNAVAPGAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADAT AFLLSEKASYITGQILSVNGGWHC*" /label="efpI CDS" gene 1574026..1574754 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /label="efpI gene" promotor_-35 1574770..1574776 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1574788 /Source="Nicolas_upshifts" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1574790..1574801 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1574801) /Source="Nicolas_upshifts" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1574812..1574826) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1574835..1574839) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1574835..1575092 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389570.1" /db_xref="EnsemblGenomes-Gn:BSU16880" /db_xref="EnsemblGenomes-Tr:CAB13561" /db_xref="InterPro:IPR021637" /db_xref="InterPro:IPR024702" /db_xref="SubtiList:BG13430" /db_xref="UniProtKB/Swiss-Prot:O31768" /translation="MSVLENWDSWKNFLGDRLNYAQDKGMSQDTITDLATEIGSYLAN EVESKNEQEKVLADLWSVASKDEQHAIANMMVKLVENNSTH*" /label="ymfJ CDS" gene 1574835..1575092 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /label="ymfJ gene" downshifts 1575077 /Source="Nicolas_upshifts" /id="D910" /incds=0 /nref=165 /ntot=250 /MaxReadThrough="4.58488" /MaxDrop="7.23574" /score="21.9507801" /energy="-8.7" /TU="U1349,U1351" /idTUdmin="U1350" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1575109) /Source="Nicolas_upshifts" /id="D911" /incds=0 /nref=2 /ntot=15 /MaxReadThrough="3.44398" /MaxDrop="3.96475" /score="-6.33040789" /energy="-7.2" /TU="NA" /idTUdmin="U1344" /TUdmin="-11987" /isTUend="FALSE" /label="downshifts" promotor_-35 1575150..1575153 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1575168..1575187 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1575168 /Source="Nicolas_upshifts" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1575222..1575737 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; N-terminal part of YmfK" /db_xref="SubtiList:BG13431" /translation="MAKLEWYFEYEIQVNRPGLLGDISSLLGMLSINIVTINGVDLSR RGMLLRCRHIDQIKRLESILKTMETIKVTKLREPRLRDRLAVRHGRYIQRDADDKKTF RFERDELGLLVDFMAELFKKEGHKLIGIRGMPRVGKTESIVASSVCEQKVAVCVINLA EADDKKPADCR*" /label="ymfKn CDS" gene 1575222..1575737 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /pseudo /label="ymfKn gene" CDS 1575673..1576011 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; C-terminal part of YmfK" /db_xref="SubtiList:BG13432" /translation="RWLFVSSTLLKQTIRSQLIADEYSTENVFIVDGIVSTRRGSERH LQLVREIMRLPATKVVEHPDIFVQNTEYTLDDFDYIIELRNDPDEVITYEHAEEPQMF DQSGFSSFDF*" /label="ymfKc CDS" gene 1575673..1576011 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /pseudo /label="ymfKc gene" CDS 1576078..1576944 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 19164570, 22720735, 23879732, 27415800, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 19164570, 22720735, 23879732, 27415800, 27818647; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell shape determination factor" /protein_id="NP_389573.3" /db_xref="EnsemblGenomes-Gn:BSU16910" /db_xref="EnsemblGenomes-Tr:CAB13564" /db_xref="GOA:O31771" /db_xref="InterPro:IPR025194" /db_xref="SubtiList:BG13433" /db_xref="UniProtKB/Swiss-Prot:O31771" /translation="MSLDDLQAATKIQKRYLTALEEGNYDIIPGKFYVRAFIKQYAEA VGLDADQLFEEHKKDIPNTYHDDVSEKISGMNLQKEMPKPASKALELLPTILVILGVI VVIAIVYAIIQFANHKNSDDHNAASEKAITQSESKYEIPKDSTLKENQNNSSEKETDT KKETKENEDKKKENDSEKLEIKAAGTEGSLTTYEVSGADKIELELKASDSSWIRVRDE NSSSLKEGTLKKDETYKKDITDQKQVDIRTGYAPNLKIKINGKVLSYELDPKKVMAQT IKIVNKKEEKSS*" /label="rodZ CDS" gene 1576078..1576944 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /label="rodZ gene" promotor_no_box 1576141..1576241 /Source="Nicolas_upshift_promotors" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_no_box" upshifts 1576201 /Source="Nicolas_upshifts" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" downshifts 1576904 /Source="Nicolas_upshifts" /id="D912" /incds=0 /nref=1 /ntot=107 /MaxReadThrough="5.43253" /MaxDrop="2.8328" /score="21.9507801" /energy="-8.7" /TU="U1353,U1354" /idTUdmin="U1351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1576994..1577575 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /EC_number="2.7.8.5" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15743965, 15849754, 16514141, 16850406, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15743965, 15849754, 16514141, 16850406, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase" /protein_id="NP_389574.2" /db_xref="EnsemblGenomes-Gn:BSU16920" /db_xref="EnsemblGenomes-Tr:CAB13565" /db_xref="GOA:P46322" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004570" /db_xref="SubtiList:BG11373" /db_xref="UniProtKB/Swiss-Prot:P46322" /translation="MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHL AGAILFIIASTTDWVDGYYARKLNLVTNFGKFLDPLADKLLVSAALIILVQFDLAPAW MVIVIISREFAVTGLRLVLAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSF PFADLALWVAVFFTVVSGWEYFSKNWEALKTSN*" /label="pgsA CDS" gene 1576994..1577575 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /label="pgsA gene" CDS 1577593..1578843 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438773, 11703670, 20480359; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence-damage inducible regulator" /protein_id="NP_389575.2" /db_xref="EnsemblGenomes-Gn:BSU16930" /db_xref="EnsemblGenomes-Tr:CAB13566" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008135" /db_xref="InterPro:IPR008136" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036653" /db_xref="SubtiList:BG11374" /db_xref="UniProtKB/Swiss-Prot:P46323" /translation="MEFPKKAEIIAVGSELLLGQIANTNAQFISKQLAEIGVNVFYHT AVGDNPERLKQVIRIAEERSDFIIFSGGLGPTKDDLTKETIANTLGRPLVLNDEAFQS IEDYFKRTKRTMSPNNRKQALVIEGSDVLANHFGMAPGMLTEHESRYYMLLPGPPSEL RPMFENEAKPLLLKKMGSNEKIVSTVLRFFGIGESQLEADLEDIIDAQTNPTIAPLAA DGEVTLRLTAKHADEKETERLLKETEAVILERVGEFFYGYDDTSLVKELSIACKEKGI TISAAESFTGGLFSEWLTDHSGASKLFAGGVVCYTNDVKQNVLGVKKETLDRFGAVSK ECASELAKGVQKLTGSDIGISFTGVAGPDAQEGHEPGHVFIGISANGKEEVHEFHFAG SRTGIRKRGAKYGCHLILKLLEQK*" /label="cinA CDS" gene 1577593..1578843 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /label="cinA gene" S_feature 1578844..1578970 /Source="Nicolas_S_feature" /locus_tag="new_1764473_1764599" /HighExp="LBGstat, LBGtran, G135, Lbstat, G150, C30, LBGexp, dia0, S0, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.016, 0.998" /TUlongSig="SigA" /TUlongPSig="0.987" /label="S604" promotor_-35 1578950..1578957 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1578972..1578991 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1578972 /Source="Nicolas_upshifts" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1579016..1580062 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191; Product type f: factor" /codon_start=1 /transl_table=11 /product="multifunctional SOS repair factor" /protein_id="NP_389576.2" /db_xref="EnsemblGenomes-Gn:BSU16940" /db_xref="EnsemblGenomes-Tr:CAB13567" /db_xref="GOA:P16971" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013765" /db_xref="InterPro:IPR020584" /db_xref="InterPro:IPR020587" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR023400" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10721" /db_xref="UniProtKB/Swiss-Prot:P16971" /translation="MSDRQAALDMALKQIEKQFGKGSIMKLGEKTDTRISTVPSGSLA LDTALGIGGYPRGRIIEVYGPESSGKTTVALHAIAEVQQQGGQAAFIDAEHALDPVYA QKLGVNIEELLLSQPDTGEQALEIAEALVRSGAVDIVVVDSVAALVPKAEIEGDMGDS HVGLQARLMSQALRKLSGAINKSKTIAIFINQIREKVGVMFGNPETTPGGRALKFYSS VRLEVRRAEQLKQGNDVMGNKTKIKVVKNKVAPPFRTAEVDIMYGEGISKEGEIIDLG TELDIVQKSGSWYSYEEERLGQGRENAKQFLKENKDIMLMIQEQIREHYGLDNNGVVQ QQAEETQEELEFEE*" /label="recA CDS" gene 1579016..1580062 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /label="recA gene" downshifts 1580074 /Source="Nicolas_upshifts" /id="D913" /incds=0 /nref=201 /ntot=262 /MaxReadThrough="4.54659" /MaxDrop="9.405" /score="23.91264" /energy="-9.7" /TU="U1355" /idTUdmin="U1353" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 1580119..1580184 /Source="Nicolas_S_feature" /locus_tag="new_1765748_1765813" /HighExp="S7, S5, S8, S4, H2O2, C30, T5.0H, S6, ferm, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="Sig-, SigA, SigA" /TUlongPSig="0.016, 0.998, 0.987" /label="S605" promotor_-35 1580156..1580165 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1580178..1580193 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1580186 /Source="Nicolas_upshifts" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1580230..1581405 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14762009, 15758244, 21856855" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762009, 15758244, 21856855; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding endopeptidase X (lysozyme resistance)" /protein_id="NP_389577.1" /db_xref="EnsemblGenomes-Gn:BSU16950" /db_xref="EnsemblGenomes-Tr:CAB13568" /db_xref="GOA:O31773" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="SubtiList:BG12642" /db_xref="UniProtKB/Swiss-Prot:O31773" /translation="MTSPTRRRTAKRRRRKLNKRGKLLFGLLAVMVCITIWNALHRNS EENEPSQETAAVSNTDQKKEVKKKTAKKSEEQIKTVDRNQKISNYLKEIGFSGTAMIV RNGEIVTNKGFGYADRKHYIQNNPLTSFYVGSSQKALIATAILQLEEKGKLQTSDPVS TYLPHFPNGQTITLKNLLTHTSGINGHIEGNGAITPDDLIKDIELQGIKRQPGVWDYK DSNYSVLAYIIAEVSGEPYEQYIKNHIFKPAGMTHAGFYKTYEKEPYPAVGYKMEGSK TVTPYIPDLSQLYGAGDIYMSAIDMYKFDQALIDGKLYSQKSYEKMFTPGSSSTYGMG FYVAPGSYSNHGVMPGFNILNSFSKSGQTIVILFSNIQNNAKLGQVNNKIYQLLNQE* " /label="pbpX CDS" gene 1580230..1581405 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /label="pbpX gene" S_feature 1581406..1581505 /Source="Nicolas_S_feature" /locus_tag="new_1767035_1767134" /HighExp="dia0, LBGexp, Lbexp, Oxctl, Paraq, H2O2, C30, G150, Mt0, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.54369999999999996" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA, Sig-, SigA, SigA" /TUlongPSig="1, 0.016, 0.998, 0.987" /label="S606" promotor_-35 1581479..1581486 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1581500..1581519 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" S_feature 1581507..1581680 /Source="Nicolas_S_feature" /locus_tag="new_1767136_1767309" /HighExp="M9-stat, T3.30H, BC, T2.0H, T3.0H, T-1.40H, T1.30H, T2.30H, T4.0H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S607" upshifts 1581507 /Source="Nicolas_upshifts" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1581681..1583243 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /EC_number="3.1.26.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease Y" /protein_id="NP_389578.1" /db_xref="EnsemblGenomes-Gn:BSU16960" /db_xref="EnsemblGenomes-Tr:CAB13569" /db_xref="GOA:O31774" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR017705" /db_xref="InterPro:IPR022711" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG13420" /db_xref="UniProtKB/Swiss-Prot:O31774" /translation="MTPIMMVLISILLILLGLVVGYFVRKTIAEAKIAGARGAAEQIL EDAKRDAEALKKEALLEAKDEIHKLRIDAEQEVRERRNELQKQENRLLQKEENLDRKH EGIDKREAMLEKKDHSLNERQQHIEEMESKVDEMIRMQQSELERISSLTRDEAKQIIL ERVENELSHDIAIMTKETENRAKEEADKKAKNILSLALQRCAADHVAETTVSVVNLPN DEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQD GRIHPARIEEMVEKSRREVDDYIREMGEQTTFEVGVHGLHPDLIKILGRLKFRTSYGQ NVLKHSMEVAFLAGLMASELGEDAKLAKRAGLLHDIGKAIDHEVEGSHVEIGVELATK YKEHPVVINSIASHHGDEEPTSIIAVLVAAADALSAARPGARSETLENYIRRLEKLEE ISESYEGVEKSFAIQAGREVRIMVKPDSINDLEAHRLARDIRKRIEDELDYPGHIKVT VIRETRAVEYAK*" /label="rny CDS" gene 1581681..1583243 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /label="rny gene" downshifts 1583220 /Source="Nicolas_upshifts" /id="D914" /incds=0 /nref=243 /ntot=268 /MaxReadThrough="5.32126" /MaxDrop="5.3789" /score="10.4712371" /energy="-9" /TU="U1357" /idTUdmin="U1357" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" CDS 1583312..1584106 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19376879, 21856853, 24163345, 26904951, 26906740" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19376879, 21856853, 24163345, 26904951, 26906740; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2'3' and 3'5' cyclic nucleotide monophosphates phosphodiesterase involved in biofilm formation" /protein_id="NP_389579.2" /db_xref="EnsemblGenomes-Gn:BSU16970" /db_xref="EnsemblGenomes-Tr:CAB13570" /db_xref="GOA:O31775" /db_xref="InterPro:IPR005235" /db_xref="InterPro:IPR029052" /db_xref="PDB:4B2O" /db_xref="SubtiList:BG13421" /db_xref="UniProtKB/Swiss-Prot:O31775" /translation="MRILFIGDVVGSPGRDMVKEYVPKLKTKYKPHFTIINGENAAHG KGLTEKIYHSLIQSGADAITMGNHTWDKKEIFDFIDDVPNLVRPANFPEGTPGKGITY VKANGKELAVINLQGRTFLPPLDDPFLKADELIAEAAKRTPYIFIDFHAEATSEKLAL GWYTDGRASAVVGTHTHVQTADNRILPKGTAYITDVGMTGPYDGILGMDRETIIKRFK TNLPVRFTVAEGKTTLSGVVIDIDDQTKKAVKIERILINDDHMFFE*" /label="pdeB CDS" gene 1583312..1584106 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /label="pdeB gene" promotor_-35 1583861..1583866 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1583882..1583900 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1583902 /Source="Nicolas_upshifts" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="upshifts" promotor_-35 1584150..1584155 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-35" S_feature 1584166..1584305 /Source="Nicolas_S_feature" /locus_tag="new_1769795_1769934" /HighExp="T5.0H, LoTm, BT, B60, S8, M9-stat, S6, BC, B36, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="0.916, 0.91, 1" /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S608" upshifts 1584166 /Source="Nicolas_upshifts" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="upshifts" promotor_-10 1584171..1584189 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-10" upshifts complement(1584198) /Source="Nicolas_upshifts" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1584209..1584222) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1584231..1584235) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1584242) /Source="Nicolas_upshifts" /id="D915" /incds=0 /nref=5 /ntot=35 /MaxReadThrough="1.51152" /MaxDrop="3.63977" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=10274 /isTUend="FALSE" /label="downshifts" CDS 1584306..1584566 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7559352, 16428420, 18562273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559352, 16428420, 18562273; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for dehydratation of the spore core and assembly of the coat (stage V sporulation)" /protein_id="NP_389580.1" /db_xref="EnsemblGenomes-Gn:BSU16980" /db_xref="EnsemblGenomes-Tr:CAB13571" /db_xref="GOA:P45693" /db_xref="InterPro:IPR007347" /db_xref="SubtiList:BG11245" /db_xref="UniProtKB/Swiss-Prot:P45693" /translation="MEILKVSAKSSPNSVAGALAGVLRERGAAEIQAIGAGALNQAVK AVAIARGFVAPSGVDLICIPAFTDIQIDGEERTAIKLIVEPR*" /label="spoVS CDS" gene 1584306..1584566 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /label="spoVS gene" downshifts 1584518 /Source="Nicolas_upshifts" /id="D916" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="8.31914" /MaxDrop="4.27515" /score="5.18548432" /energy="-12.5" /TU="U1357,U1358,U1359" /idTUdmin="U1357" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts complement(1584550) /Source="Nicolas_upshifts" /id="D917" /incds=0 /nref=3 /ntot=15 /MaxReadThrough="1.16149" /MaxDrop="3.88837" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=9966 /isTUend="FALSE" /label="downshifts" downshifts 1584562 /Source="Nicolas_upshifts" /id="D918" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.08266" /MaxDrop="5.124" /score="5.18548432" /energy="-12.5" /TU="U1358,U1359" /idTUdmin="U1357" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1584607..1584781 /Source="Nicolas_S_feature" /locus_tag="new_1770236_1770410" /HighExp="S6, S8, S7, M9-stat, Lbstat, BT, S5, T1.30H, T2.0H, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.916, 0.91" /TUlongSig="SigA, SigWXY" /TUlongPSig="1, 1" /label="S609" promotor_-35 1584765..1584772 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1584783 /Source="Nicolas_upshifts" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1584787..1584806 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1584832..1585875 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /EC_number="1.1.1.103" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8519804, 16817900, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine 3-dehydrogenase" /protein_id="NP_389581.1" /db_xref="EnsemblGenomes-Gn:BSU16990" /db_xref="EnsemblGenomes-Tr:CAB13572" /db_xref="GOA:O31776" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR004627" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12685" /db_xref="UniProtKB/Swiss-Prot:O31776" /translation="MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICG TDVHIYNWDQWARQRIKTPYVFGHEFSGIVEGVGENVSSVKVGEYVSAETHIVCGECV PCLTGKSHVCTNTAIIGVDTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVH TVLESQPAGGTTAVIGCGPIGLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTV SIEKEDPLKIVSALTSGEGADLVCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTI DLTNKVVFKGLTIQGITGRKMFSTWRQVSQLISSNMIDLAPVITHQFPLEEFEKGFEL MRSGQCGKVILIP*" /label="tdh CDS" gene 1584832..1585875 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /label="tdh gene" CDS 1585888..1587066 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /EC_number="2.3.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17146529, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase)" /protein_id="NP_389582.1" /db_xref="EnsemblGenomes-Gn:BSU17000" /db_xref="EnsemblGenomes-Tr:CAB13573" /db_xref="GOA:O31777" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR010962" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12610" /db_xref="UniProtKB/Swiss-Prot:O31777" /translation="MTKEFEFLKAELNSMKENHTWQDIKQLESMQGPSVTVNHQKVIQ LSSNNYLGFTSHPRLINAAQEAVQQYGAGTGSVRTIAGTFTMHQELEKKLAAFKKTEA ALVFQSGFTTNQGVLSSILSKEDIVISDELNHASIIDGIRLTKADKKVYQHVNMSDLE RVLRKSMNYRMRLIVTDGVFSMDGNIAPLPDIVELAEKYDAFVMVDDAHASGVLGENG RGTVNHFGLDGRVHIQVGTLSKAIGVLGGYAAGSKVLIDYLRHKGRPFLFSTSHPPAV TAACMEAIDVLLEEPEHMERLWENTAYFKAMLVKMGLTLTKSETPILPILIGDEGVAK QFSDQLLSRGVFAQSIVFPTVAKGKARIRTIITAEHTKDELDQALDVIEKTAKELQLL *" /label="kbl CDS" gene 1585888..1587066 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /label="kbl gene" downshifts 1587048 /Source="Nicolas_upshifts" /id="D919" /incds=0 /nref=3 /ntot=25 /MaxReadThrough="5.75732" /MaxDrop="3.4918" /score="4.73069387" /energy="-12.5" /TU="U1361" /idTUdmin="U1359" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" promotor_-35 1587146..1587149 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1587158 /Source="Nicolas_upshifts" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1587164..1587183 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1587214..1588743 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /EC_number="2.8.4.3" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15175311, 18307109, 20472640, 20584901, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 18307109, 20472640, 20584901, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme for ms(2)i(6)A formation for tRNA modification" /protein_id="NP_389583.1" /db_xref="EnsemblGenomes-Gn:BSU17010" /db_xref="EnsemblGenomes-Tr:CAB13574" /db_xref="GOA:O31778" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006463" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="SubtiList:BG13418" /db_xref="UniProtKB/Swiss-Prot:O31778" /translation="MNEKQKLESGQVHPSDKKSEKDYSKYFEAVYIPPSLKDAKKRGK EAVTYHNDFKISEQFKGLGDGRKFYIRTYGCQMNEHDTEVMAGIFMALGYEATNSVDD ANVILLNTCAIRENAENKVFGELGHLKALKKNNPDLILGVCGCMSQEESVVNRILKKH PFVDMIFGTHNIHRLPELLSEAYLSKEMVVEVWSKEGDVIENLPKVRNGKIKGWVNIM YGCDKFCTYCIVPYTRGKERSRRPEDIIQEVRRLASEGYKEITLLGQNVNAYGKDFED MTYGLGDLMDELRKIDIPRIRFTTSHPRDFDDRLIEVLAKGGNLLDHIHLPVQSGSSE VLKLMARKYDRERYMELVRKIKEAMPNASLTTDIIVGFPNETDEQFEETLSLYREVEF DSAYTFIYSPREGTPAAKMKDNVPMRVKKERLQRLNALVNEISAKKMKEYEGKVVEVL VEGESKNNPDILAGYTEKSKLVNFKGPKEAIGKIVRVKIQQAKTWSLDGEMVGEAIEV K*" /label="miaB CDS" gene 1587214..1588743 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /label="miaB gene" CDS 1588745..1589176 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator for biofilm formation via regulation of RNase Y (RicAFT complex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389584.1" /db_xref="EnsemblGenomes-Gn:BSU17020" /db_xref="EnsemblGenomes-Tr:CAB13575" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR016783" /db_xref="InterPro:IPR023378" /db_xref="PDB:2PIH" /db_xref="SubtiList:BG13417" /db_xref="UniProtKB/Swiss-Prot:O31779" /translation="MTLYSKKDIVQQARNLAKMISETEEVDFFKRAEAQINENDKVST IVNQIKALQKQAVNLKHYEKHEALKQVEAKIDALQEELEEIPVIQEFRDSQMEVNDLL QLVAHTISNQVTNEIITSTGGDLLKGETGSKVKHSNNSCSL*" /label="ricA CDS" gene 1588745..1589176 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /label="ricA gene" downshifts 1589159 /Source="Nicolas_upshifts" /id="D920" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="0.9572" /MaxDrop="7.73043" /score="21.1260722" /energy="-10.3" /TU="NA" /idTUdmin="U1361" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1589307..1589312 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1589328..1589346 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1589336..1589437 /Source="Nicolas_S_feature" /locus_tag="new_1774965_1775066" /HighExp="S3, S5, S8, S4, S6, S7, B36, BT, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S610" upshifts 1589336 /Source="Nicolas_upshifts" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="upshifts" CDS 1589438..1589983 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenic spore protein" /protein_id="NP_389585.1" /db_xref="EnsemblGenomes-Gn:BSU17030" /db_xref="EnsemblGenomes-Tr:CAB13576" /db_xref="GOA:P14016" /db_xref="InterPro:IPR018901" /db_xref="SubtiList:BG10494" /db_xref="UniProtKB/Swiss-Prot:P14016" /translation="MSEYREIITKAVVAKGRKFTQCTNTISPEKKPSSILGGWIINHK YDAEKIGKTVEIEGYYDINVWYSYADNTKTEVVTERVKYVDVIKLRYRDNNYLDDEHE VIAKVLQQPNCLEVTISPNGNKIVVQAEREFLAEVVGETKVVVEVNPDWEEDDEEDWE DELDEELEDINPEFLVGDPEE*" /label="cotE CDS" gene 1589438..1589983 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /label="cotE gene" downshifts 1589977 /Source="Nicolas_upshifts" /id="D921" /incds=0 /nref=64 /ntot=97 /MaxReadThrough="4.37388" /MaxDrop="8.23792" /score="10.7927556" /energy="-12.6" /TU="U1363" /idTUdmin="U1363" /TUdmin="-745" /isTUend="FALSE" /label="downshifts" downshifts complement(1589984) /Source="Nicolas_upshifts" /id="D922" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="4.21458" /MaxDrop="3.44208" /score="12.3953461" /energy="-11.4" /TU="NA" /idTUdmin="U1366" /TUdmin=4532 /isTUend="FALSE" /label="downshifts" promotor_-35 1590041..1590044 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1590059..1590078 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1590063 /Source="Nicolas_upshifts" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="upshifts" CDS 1590116..1592692 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /function="16.5: Explore" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15375129, 16269814, 23998896, 26343983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 16269814, 23998896, 26343983; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA mismatch repair recognition factor" /protein_id="NP_389586.2" /db_xref="EnsemblGenomes-Gn:BSU17040" /db_xref="EnsemblGenomes-Tr:CAB13577" /db_xref="GOA:P49849" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR005748" /db_xref="InterPro:IPR007695" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR007860" /db_xref="InterPro:IPR007861" /db_xref="InterPro:IPR016151" /db_xref="InterPro:IPR017261" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036187" /db_xref="InterPro:IPR036678" /db_xref="SubtiList:BG11403" /db_xref="UniProtKB/Swiss-Prot:P49849" /translation="MAGYTPMIQQYLKIKAEHQDAFLFFRLGDFYEMFFEDAKKASQE LEITLTSRDGGAAEKIPMCGVPYHSASAYIEQLIKKGYKVAICEQTEDPKAAKGVVKR EVVQLITPGTVMDGKGIHESENNFIASVSACSNGYGLALSDLTTGENLAVLIERLEDV ISEIYSVGAREIVVSGSLDADTVAQLRERCGATISIEDGETDEHVTIIEHLNNEDITK TFLRLYTYLKRTQKRSLDHLQPVQVYELEEAMKIDLYSKRNLELTETIRSKNKKGSLL WLLDETKTAMGGRLLKQWIDRPLIRVNQIEERQEMVETLMSHFFEREDLRERLKEVYD LERLAGRVAFGNVNARDLIQLKESLKQVPGIKQLVASLAHDKAKERAKRIDPCGDVLE LLEEALYENPPLSVKEGNLIKDGYNQKLDEYRDASRNGKDWIARLEQQEREYTGIRSL KVGFNKVFGYYIEVTKANLHLLEEGRYERKQTLTNAERYITPELKEKEALILEAENNI CELEYELFTELREKVKQYIPRLQQLAKQMSELDALQCFATISENRHYTKPEFSKDEVE VIEGRHPVVEKVMDSQEYVPNNCMMGDNRQMLLITGPNMSGKSTYMRQIALISIMAQI GCFVPAKKAVLPIFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIVNATKNSLILFDE IGRGTSTYDGMALAQAIIEYVHDHIGAKTLFSTHYHELTVLEDKLPQLKNVHVRAEEY NGTVVFLHQIKEGAADKSYGIHVAQLAELPGDLIARAQDILKELEHSGNKPEVPVQKP QVKEEPAQLSFFDEAEKPAETPKLSKKEKQVIDAFKSLNILDMTPLEAMNEMYKLQKK LH*" /label="mutS CDS" gene 1590116..1592692 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /label="mutS gene" CDS 1592708..1594591 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15375129, 22843852, 26343983, 26384423, 27369079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 22843852, 26343983, 26384423, 27369079; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA mismatch repair endonuclease" /protein_id="NP_389587.1" /db_xref="EnsemblGenomes-Gn:BSU17050" /db_xref="EnsemblGenomes-Tr:CAB13578" /db_xref="GOA:P49850" /db_xref="InterPro:IPR002099" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR013507" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR014762" /db_xref="InterPro:IPR014790" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020667" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037198" /db_xref="PDB:3GAB" /db_xref="PDB:3KDG" /db_xref="PDB:3KDK" /db_xref="SubtiList:BG11402" /db_xref="UniProtKB/Swiss-Prot:P49850" /translation="MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIE IDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPS IASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYM KTVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAK KMLPLHVSSLDFEVKGYIALPEITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLP IGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDGIKDVFKQQQLIPSA QVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPP LQFDAPPIVDQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYI LAQNENGLYIIDQHAAQERIKYEYFREKVGEVEPEVQEMIVPLTFHYSTNEALIIEQH KQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDIKKLREE AAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFK RVM*" /label="mutL CDS" gene 1592708..1594591 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /label="mutL gene" S_feature complement(1594494..1594988) /Source="Nicolas_S_feature" /locus_tag="new_1780123_1780617_c" /HighExp="M9-stat, LBGstat, LPhT, T2.0H, Lbstat, C30, T2.30H, M0t90, T1.30H, HiOs" /AntisenseName="mutL" /AntisenseCor="0.27126904061692803" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S611" downshifts 1594506 /Source="Nicolas_upshifts" /id="D923" /incds=1 /nref=216 /ntot=257 /MaxReadThrough="2.0064" /MaxDrop="5.37369" /score="33.4967163" /energy="-18.6" /TU="NA" /idTUdmin="U1364" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1594516) /Source="Nicolas_upshifts" /id="D924" /incds=1 /nref=3 /ntot=100 /MaxReadThrough="1.93338" /MaxDrop="2.7192" /score="27.1353816" /energy="-13.5" /TU="NA" /idTUdmin="U1366" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1594738..1594745 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1594760..1594779 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1594770..1594903 /Source="Nicolas_S_feature" /locus_tag="new_1780399_1780532" /HighExp="LoTm, T0.30H, T1.30H, M9-stat, T3.0H, BC, T1.0H, B60, B36, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99494800000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S612" upshifts 1594770 /Source="Nicolas_upshifts" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1594775..1594925) /gene="surX" /locus_tag="BSU_misc_RNA_89" /product="small untranslated RNA of unknown function" /note="Evidence 5: Unknown function; PubMedId : 20525796, 23155385" /label="surX RNA" gene complement(1594775..1594925) /gene="surX" /locus_tag="BSU_misc_RNA_89" /label="surX gene" downshifts 1594860 /Source="Nicolas_upshifts" /id="D925" /incds=0 /nref=19 /ntot=136 /MaxReadThrough="3.45962" /MaxDrop="4.12444" /score="29.4045648" /energy="-15.3" /TU="U1365" /idTUdmin="U1364" /TUdmin=354 /isTUend="FALSE" /label="downshifts" CDS complement(1594989..1595444) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="YP_054578.1" /db_xref="EnsemblGenomes-Gn:BSU17060" /db_xref="EnsemblGenomes-Tr:CAE01453" /db_xref="GOA:Q7WY71" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14188" /db_xref="UniProtKB/Swiss-Prot:Q7WY71" /translation="MNQKEQNEHSKDFNLRSKLIGIVSITFIAAIALAVIFGGFFFGM KGLFSILGITYASNQTLALFILACFAVGLIIDPLTKIISIILAKSLSLKKTALFAFIL YFISNLITICFADYFMQSIYIPDVLLVVISAFMAIIELAFDNQPNREAA*" /label="ymzD CDS" gene complement(1594989..1595444) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /label="ymzD gene" S_feature complement(1595445..1595536) /Source="Nicolas_S_feature" /locus_tag="new_1781074_1781165_c" /HighExp="LBGstat, M9-stat, T1.0H, T1.30H, T2.0H, M0t90, MG 150, LPhT, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S613" promotor_-10 complement(1595524..1595543) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1595536) /Source="Nicolas_upshifts" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1595560..1595563) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1595599..1596156) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389588.1" /db_xref="EnsemblGenomes-Gn:BSU17070" /db_xref="EnsemblGenomes-Tr:CAB13579" /db_xref="GOA:O31780" /db_xref="SubtiList:BG13419" /db_xref="UniProtKB/Swiss-Prot:O31780" /translation="MNGIAWMIVFCEIAFWVVIVLGLAVRYVFKRHTLGLLFLALTPV IDLILLAATGVDLYRGASATAAHGIAAVYIGISIAYGKQMIQWADEKFQYYVTKKGTK PLKRFGMDHAKHGAKGWLRHVLAYLIGAGLLAGMIYFINDSSRTEALSGILKLWTVII GIDFLITASYFIWPKKEKASANLRS*" /label="ymcC CDS" gene complement(1595599..1596156) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /label="ymcC gene" SCAR 1596247..1596248 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs08" downshifts complement(1596299) /Source="Nicolas_upshifts" /id="D929" /incds=0 /nref=24 /ntot=184 /MaxReadThrough="3.69744" /MaxDrop="5.18486" /score="-0.71313204" /energy="-20.1" /TU="U1374" /idTUdmin="U1375" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(1596305..1596661) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11544224, 15805528, 20817675" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function involved in ethanol resistance" /protein_id="NP_389606.3" /db_xref="EnsemblGenomes-Gn:BSU17240" /db_xref="EnsemblGenomes-Tr:CAB13608" /db_xref="SubtiList:BG13435" /db_xref="UniProtKB/Swiss-Prot:O31786" /translation="MAHTNTQLSQWLESKVGQTLDIRKGELTHDEEISDLDQIVLHLQ KVAIRSTNHPDDYVAKEELVLEGEGTTFTEDGNVPLPQNAYEIPLLGELHIHQENEGL KVVTDRAVYTIDIQHS*" /label="ymzB CDS" gene complement(1596305..1596661) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /label="ymzB gene" misc_feature complement(1596721..1596734) /Source="Nicolas_upshift_promotors" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1596726) /Source="Nicolas_upshifts" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1596740..1597564) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20817675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389607.2" /db_xref="EnsemblGenomes-Gn:BSU17250" /db_xref="EnsemblGenomes-Tr:CAB13609" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13413" /db_xref="UniProtKB/Swiss-Prot:O31787" /translation="MPYYICNTCGVQHAQTVDPPNSCLICEDERQYIHPDGQTWTTLE DMREKGNLQNILKKEEEHLYSIKTEPEFAIGQTAHLIQHKGFNVLWDCMTYLDQKTID QINELGGIQAIALSHPHYYSTQVEWAEAFQAPIYIHEDDKEWVTRPSNHIHFWSGETL NMKPGLDLYRLGGHFKGGAVLHWSKGNEGKGCLLTGDIITVAADRNWVSFMYSYPNLI PLPASKVEEIAAKVKPLQFNRLYNAFSKVVKENADESVQRSAVRYIKALNSELFHT*" /label="ymaE CDS" gene complement(1596740..1597564) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /label="ymaE gene" promotor_-10 complement(1597586..1597605) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1597602) /Source="Nicolas_upshifts" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1597617..1597623) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1597675..1599003) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10589719, 16267290, 17884659, 28693413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10589719, 16267290, 17884659, 28693413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline serine protease" /protein_id="NP_389608.1" /db_xref="EnsemblGenomes-Gn:BSU17260" /db_xref="EnsemblGenomes-Tr:CAB13610" /db_xref="GOA:O31788" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG12567" /db_xref="UniProtKB/Swiss-Prot:O31788" /translation="MFGYSMVQMVRANAHKLDWPLRETVLQLYKPFKWTPCFLHKFFE TKLQNRKKMSVIIEFEEGCHETGFQMAGEVLQKEKRSKLKSRFNKINCCSAEVTPSAL HSLLSECSNIRKVYLNREVKALLDTATEASHAKEVVRNGQTLTGKGVTVAVVDTGIYP HPDLEGRIIGFADMVNQKTEPYDDNGHGTHCAGDVASSGASSSGQYRGPAPEANLIGV KVLNKQGSGTLADIIEGVEWCIQYNEDNPDEPIDIMSMSLGGDALRYDHEQEDPLVRA VEEAWSAGIVVCVAAGNSGPDSQTIASPGVSEKVITVGALDDNNTASSDDDTVASFSS RGPTVYGKEKPDILAPGVNIISLRSPNSYIDKLQKSSRVGSQYFTMSGTSMATPICAG IAALILQQNPDLTPDEVKELLKNGTDKWKDEDPNIYGAGAVNAENSVPGQ*" /label="aprX CDS" gene complement(1597675..1599003) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /label="aprX gene" downshifts complement(1597682) /Source="Nicolas_upshifts" /id="D930" /incds=0 /nref=13 /ntot=21 /MaxReadThrough="2.43809" /MaxDrop="5.8915" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1376" /TUdmin=8 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1599026..1599045) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1599045) /Source="Nicolas_upshifts" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1599059..1599067) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1599160..1599167 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1599175..1599194) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1599183..1599202 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1599186) /Source="Nicolas_upshifts" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" upshifts 1599189 /Source="Nicolas_upshifts" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1599207..1599214) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1599228..1599305 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of YmzE" /translation="MNFYLHRSLESQMPISIIYEERRND*" /label="ymzEn CDS" gene 1599228..1599305 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /pseudo /label="ymzEn gene" downshifts complement(1599230) /Source="Nicolas_upshifts" /id="D931" /incds=0 /nref=4 /ntot=7 /MaxReadThrough="1.51659" /MaxDrop="5.37668" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1377" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS 1599283..1599459 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of YmzE" /db_xref="PSEUDO:CAX52622.1" /translation="MKKDGTISKRTIIVRQKSKTKIKAFCFSKQQIRTFLLDSILSCD FVRTNKQNLYSAGR*" /label="ymzEc CDS" gene 1599283..1599459 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /pseudo /label="ymzEc gene" downshifts 1599440 /Source="Nicolas_upshifts" /id="D932" /incds=0 /nref=42 /ntot=207 /MaxReadThrough="4.03151" /MaxDrop="6.55778" /score="-0.929304655" /energy="-5.5" /TU="U1378" /idTUdmin="U1378" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature 1599485..1599673 /Source="Nicolas_S_feature" /locus_tag="new_1863194_1863382" /HighExp="H2O2, M40t90, C90, M40t45, C30, S8, HiOs, G135, T-4.40H, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S619" misc_feature 1599668..1599687 /Source="Nicolas_upshift_promotors" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1599675 /Source="Nicolas_upshifts" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1599739..1600446 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /EC_number="3.4.19.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16267290, 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="gamma-polyglutamate hydrolase (phage origin)" /protein_id="NP_389609.1" /db_xref="EnsemblGenomes-Gn:BSU17270" /db_xref="EnsemblGenomes-Tr:CAB13611" /db_xref="GOA:O31789" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13411" /db_xref="UniProtKB/Swiss-Prot:O31789" /translation="MRRFLLNVILVLAIVLFLRYVHYSLEPEPSNQPDTYSNFSSLAE NESPADYDISYNEKKGSKVLIMSPHGGRIEGGVSELVRYFNNEYSTYLFEGLKSHDNQ TLHITSTNFDEPLAKKKIKEHQYVVAFHGYKGENKNTLVGGTDRKRAKMIVRALERRG FSAELASSKSGLAGLNAENINNQGETGLSIQLEISREQREAFFDDFYYKNRKYTKNSE FYAYVSAIKGVLEKEYS*" /label="pghC CDS" gene 1599739..1600446 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /label="pghC gene" promotor_-35 1600457..1600463 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1600477..1600496 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1600481 /Source="Nicolas_upshifts" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1600516..1600968 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290, 22904090, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peroxiredoxin-related protein" /protein_id="NP_389610.1" /db_xref="EnsemblGenomes-Gn:BSU17280" /db_xref="EnsemblGenomes-Tr:CAB13612" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019905" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13412" /db_xref="UniProtKB/Swiss-Prot:O31790" /translation="MADHHFYLKANWPGNRNDVGTIESGNLITSISIPKEMDGPGEGT NPDEMLLGAAATCYIITLAAMMERSGLEKEDLQMESEGIVNVTKGVFTYKKIIHRPSV VLKHDASQDDVALAHKLCKKAESSCMISRAIQGNVELQLEASVKLGGE*" /label="ymaD CDS" gene 1600516..1600968 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /label="ymaD gene" downshifts 1600956 /Source="Nicolas_upshifts" /id="D933" /incds=0 /nref=44 /ntot=182 /MaxReadThrough="1.35366" /MaxDrop="6.07534" /score="17.0193804" /energy="-12.1" /TU="NA" /idTUdmin="U1379" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1600982..1601335) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 15849754, 16750162, 16850406, 18024586, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 15849754, 16750162, 16850406, 18024586, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389611.1" /db_xref="EnsemblGenomes-Gn:BSU17290" /db_xref="EnsemblGenomes-Tr:CAB13613" /db_xref="GOA:P0CW82" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12586" /db_xref="UniProtKB/Swiss-Prot:P0CW82" /translation="MRGLLYLALAIVSEVFGSTMLKLSEGFTQAWPIAGVIVGFLSAF TFLSFSLKTIDLSSAYATWSGVGTALTAIVGFLLFGETISLKGVFGLTLVIAGVVVLN QSKAHAEDKKQTACE*" /label="ebrB CDS" gene complement(1600982..1601335) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /label="ebrB gene" downshifts complement(1601023) /Source="Nicolas_upshifts" /id="D934" /incds=0 /nref=2 /ntot=45 /MaxReadThrough="0.84905" /MaxDrop="2.87924" /score="-2.89884673" /energy="-8.7" /TU="NA" /idTUdmin="U1381" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1601349..1601666) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 11104814, 17516673, 18024586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 11104814, 17516673, 18024586; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389612.1" /db_xref="EnsemblGenomes-Gn:BSU17300" /db_xref="EnsemblGenomes-Tr:CAB13614" /db_xref="GOA:P0CW80" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12585" /db_xref="UniProtKB/Swiss-Prot:P0CW80" /translation="MLIGYIFLTIAICSESIGAAMLKVSDGFKKWKPSALVVIGYSLA FYMLSLTLNHIPLSLSYATWSGAGTVLTTVIGVKWFKEDLNAKGLIGILLLLSGVVLL NWP*" /label="ebrA CDS" gene complement(1601349..1601666) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /label="ebrA gene" promotor_-10 complement(1601710..1601729) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1601718) /Source="Nicolas_upshifts" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1601744..1601751) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1601803..1602078) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19775244, 19933362, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19775244, 19933362, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein; cell wall associated protein" /protein_id="NP_389613.2" /db_xref="EnsemblGenomes-Gn:BSU17310" /db_xref="EnsemblGenomes-Tr:CAB13615" /db_xref="GOA:O31793" /db_xref="SubtiList:BG13415" /db_xref="UniProtKB/Swiss-Prot:O31793" /translation="MNELEHFSPEDTRIFGRPFGFGRPFGFGRPFGFGYGFGRPGFGY GFGRPFGFFGGPFIGGLAGGLIGSALFNPYLYGGYPYYPYAPFPFYY*" /label="ymaG CDS" gene complement(1601803..1602078) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /label="ymaG gene" downshifts complement(1601804) /Source="Nicolas_upshifts" /id="D935" /incds=0 /nref=38 /ntot=44 /MaxReadThrough="0.28059" /MaxDrop="8.33353" /score="12.3408391" /energy="-11.5" /TU="NA" /idTUdmin="U1383" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1602074..1602079 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-35" promotor_-10 1602095..1602113 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-10" promotor_-10 complement(1602105..1602124) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1602115 /Source="Nicolas_upshifts" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="upshifts" upshifts complement(1602118) /Source="Nicolas_upshifts" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1602137..1602146) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1602167..1602580 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24098137, 25915524" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein of unknown function" /protein_id="NP_389614.2" /db_xref="EnsemblGenomes-Gn:BSU17320" /db_xref="EnsemblGenomes-Tr:CAB13616" /db_xref="InterPro:IPR024307" /db_xref="SubtiList:BG13414" /db_xref="UniProtKB/Swiss-Prot:O31794" /translation="MNTLGLYQSDWSKAPPHAHAYHVKTTREQGHYHLIEGFTQPANG SNTDQHTHYYTGITSFENGHFHRYYGISGPAIPLADGTHYHEIEETTYLAYNEPIEIQ YGGVVYDPGDDRRKTHRHTLKGKTREIVGNEPLGW*" /label="ymaF CDS" gene 1602167..1602580 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /label="ymaF gene" upshifts 1602631 /Source="Nicolas_upshifts" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="upshifts" misc_feature 1602637..1602656 /Source="Nicolas_upshift_promotors" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1602680..1603624 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /EC_number="2.5.1.75" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3045085, 11160115, 26735940, 28277934, 28471404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA isopentenylpyrophosphate transferase" /protein_id="NP_389615.2" /db_xref="EnsemblGenomes-Gn:BSU17330" /db_xref="EnsemblGenomes-Tr:CAB13617" /db_xref="GOA:O31795" /db_xref="InterPro:IPR018022" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12617" /db_xref="UniProtKB/Swiss-Prot:O31795" /translation="MNNTKQPVVILVGPTAVGKTNLSIQLAKSLNAEIISGDSMQIYK GMDIGTAKITEQEMEGVPHHLIDILDPQDSFSTADYQSLVRNKISEIANRGKLPMIVG GTGLYIQSVLYDYTFTEEANDPVFRESMQMAAEREGADFLHAKLAAADPEAAAAIHPN NTRRVIRALEILHTSGKTMSQHLKEQKRELLYNAVLIGLTMDRDTLYERINQRVDLMM QSGLLPEVKRLYDKNVRDCQSIQAIGYKELYAYFDGFVTLSDAVEQLKQNSRRYAKRQ LTWFRNKMQVTWFDMTPPVDMELKKKEIFTHIAGKLEL*" /label="miaA CDS" gene 1602680..1603624 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /label="miaA gene" promotor_-35 1603604..1603612 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-35" promotor_-10 1603623..1603641 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-10" upshifts 1603625 /Source="Nicolas_upshifts" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="upshifts" CDS 1603664..1603885 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927; Product type f: factor" /codon_start=1 /transl_table=11 /product="Hfq RNA chaperone" /protein_id="NP_389616.1" /db_xref="EnsemblGenomes-Gn:BSU17340" /db_xref="EnsemblGenomes-Tr:CAB13618" /db_xref="GOA:O31796" /db_xref="InterPro:IPR005001" /db_xref="InterPro:IPR010920" /db_xref="PDB:3AHU" /db_xref="PDB:3HSB" /db_xref="SubtiList:BG13416" /db_xref="UniProtKB/Swiss-Prot:O31796" /translation="MKPINIQDQFLNQIRKENTYVTVFLLNGFQLRGQVKGFDNFTVL LESEGKQQLIYKHAISTFAPQKNVQLELE*" /label="hfq CDS" gene 1603664..1603885 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /label="hfq gene" downshifts complement(1603675) /Source="Nicolas_upshifts" /id="D936" /incds=0 /nref=3 /ntot=108 /MaxReadThrough="1.19472" /MaxDrop="3.56162" /score="-5.83707008" /energy="-5.2" /TU="NA" /idTUdmin="U1386" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1603737..1603741) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1603741) /Source="Nicolas_upshifts" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1603756..1603761) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1603885 /Source="Nicolas_upshifts" /id="D937" /incds=0 /nref=26 /ntot=212 /MaxReadThrough="5.10866" /MaxDrop="4.06475" /score="17.2354231" /energy="-17" /TU="U1382,U1385" /idTUdmin="U1384" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1604081..1604353 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389617.1" /db_xref="EnsemblGenomes-Gn:BSU17350" /db_xref="EnsemblGenomes-Tr:CAB13619" /db_xref="InterPro:IPR025448" /db_xref="PDB:3KVP" /db_xref="SubtiList:BG13436" /db_xref="UniProtKB/Swiss-Prot:O31797" /translation="MFESEAELRRIRIALVWIAVFLLFGACGNQDTIIETDNGNSDYE TPQPTSFPLEHNHFGVMEDGYIKIYEYNESRNEVKLKKEYADDELE*" /label="ymzC CDS" gene 1604081..1604353 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /label="ymzC gene" promotor_-35 1604369..1604376 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1604390..1604409 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1604392 /Source="Nicolas_upshifts" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="upshifts" CDS 1604435..1604665 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389618.1" /db_xref="EnsemblGenomes-Gn:BSU17360" /db_xref="EnsemblGenomes-Tr:CAB13620" /db_xref="SubtiList:BG13434" /db_xref="UniProtKB/Swiss-Prot:O31798" /translation="MKHKVIVNHWEEICEDDSCYEYGTSIIVNGKELIREASIITALK AVLEEIGADVEIEETVESEKCCDSLRKKNLDY*" /label="ymzA CDS" gene 1604435..1604665 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /label="ymzA gene" S_feature 1604666..1604742 /Source="Nicolas_S_feature" /locus_tag="new_1868375_1868451" /HighExp="dia5, dia15, Diami, B60, G150, H2O2, LPhT, G180, G135, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S620" downshifts 1604699 /Source="Nicolas_upshifts" /id="D938" /incds=0 /nref=24 /ntot=61 /MaxReadThrough="7.47169" /MaxDrop="4.19691" /score="8.2587309" /energy="-16.9" /TU="U1385,U1387" /idTUdmin="U1385" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 1604744..1604851 /Source="Nicolas_S_feature" /locus_tag="new_1868453_1868560" /HighExp="G180, G150, G135, H2O2, dia15, Paraq, LBGexp, C30, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S621" promotor_-35 1604824..1604831 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1604845..1604864 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1604853 /Source="Nicolas_upshifts" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="upshifts" CDS 1604908..1605300 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16885274, 21561096, 22443445, 23402532, 26507228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16885274, 21561096, 22443445, 23402532, 26507228; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-factor of ribonucleotide diphosphate reductase" /protein_id="NP_389619.1" /db_xref="EnsemblGenomes-Gn:BSU17370" /db_xref="EnsemblGenomes-Tr:CAB13621" /db_xref="GOA:P50618" /db_xref="InterPro:IPR004465" /db_xref="InterPro:IPR020852" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLJ" /db_xref="SubtiList:BG11426" /db_xref="UniProtKB/Swiss-Prot:P50618" /translation="MVQIIFDSKTGNVQRFVNKTGFQQIRKVDEMDHVDTPFVLVTYT TNFGQVPASTQSFLEKYAHLLLGVAASGNKVWGDNFAKSADTISRQYQVPILHKFELS GTSKDVELFTQEVERVVTKSSAKMDPVK*" /label="nrdI CDS" gene 1604908..1605300 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /label="nrdI gene" CDS 1605260..1607362 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (major subunit)" /protein_id="NP_389620.1" /db_xref="EnsemblGenomes-Gn:BSU17380" /db_xref="EnsemblGenomes-Tr:CAB13622" /db_xref="GOA:P50620" /db_xref="InterPro:IPR000788" /db_xref="InterPro:IPR008926" /db_xref="InterPro:IPR013346" /db_xref="InterPro:IPR013509" /db_xref="InterPro:IPR013554" /db_xref="InterPro:IPR026459" /db_xref="SubtiList:BG11404" /db_xref="UniProtKB/Swiss-Prot:P50620" /translation="MSQNQVPKWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQN TVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYN DYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAG RKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVEN ATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVK TLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKFVDNPRVKK EKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHANNHISKVKFSNLCSEVLQASQVS SYTDYDEEDEIGLDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPA VRRANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAK EKGETFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLFEGMHIPTTEDWKKLKAFVA EHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWF FYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFLKDTMTTRDLNRIDLYAHHRGIKTI YYARTKDTGQDSCLSCVV*" /label="nrdE CDS" gene 1605260..1607362 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /label="nrdE gene" CDS 1607380..1608369 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (minor subunit)" /protein_id="NP_389621.1" /db_xref="EnsemblGenomes-Gn:BSU17390" /db_xref="EnsemblGenomes-Tr:CAB13623" /db_xref="GOA:P50621" /db_xref="InterPro:IPR000358" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR026494" /db_xref="InterPro:IPR030475" /db_xref="InterPro:IPR033909" /db_xref="PDB:4DR0" /db_xref="SubtiList:BG11405" /db_xref="UniProtKB/Swiss-Prot:P50621" /translation="MTKIYDAANWSKHEDDFTQMFYNQNVKQFWLPEEIALNGDLLTW KYLGKNEQDTYMKVLAGLTLLDTEQGNTGMPIVAEHVDGHQRKAVLNFMAMMENAVHA KSYSNIFMTLAPTETINEVFEWVKQNKYLQKKAQMIVGLYKAIQKDDEISLFKAMVAS VYLESFLFYSGFYYPLYFYGQGKLMQSGEIINLILRDEAIHGVYVGLLAQEIYNKQTE EKKAELREFAIDLLNQLYENELEYTEDLYDQVGLSHDVKKFIRYNANKALMNLGFDPY FEEEDINPIVLNGLNTKTKSHDFFSMKGNGYKKATVEPLKDDDFYFEDEKEQI*" /label="nrdF CDS" gene 1607380..1608369 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /label="nrdF gene" downshifts 1608329 /Source="Nicolas_upshifts" /id="D939" /incds=0 /nref=3 /ntot=106 /MaxReadThrough="6.49299" /MaxDrop="2.8143" /score="-8.26008921" /energy="-10.8" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(1608383..1609042) /Source="Nicolas_S_feature" /locus_tag="new_1872092_1872751_c" /HighExp="BT, B36, C30, Pyr, S8, G135, G/S, Glucon, B60, C90" /AntisenseName="ymaB" /AntisenseCor="-0.136438199650502" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S622" downshifts complement(1608398) /Source="Nicolas_upshifts" /id="D940" /incds=0 /nref=3 /ntot=8 /MaxReadThrough="2.78803" /MaxDrop="4.0424" /score="6.77419677" /energy="-10.8" /TU="NA" /idTUdmin="U1390" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 1608419..1609039 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885274, 21561096; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative cofactor involved in deoxyribonucleotide synthesis" /protein_id="NP_389622.1" /db_xref="EnsemblGenomes-Gn:BSU17400" /db_xref="EnsemblGenomes-Tr:CAB13624" /db_xref="GOA:P50619" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG11427" /db_xref="UniProtKB/Swiss-Prot:P50619" /translation="MGKMDEMILVAPRDDVFKKESLTFQGVYSEDSRVAEIMAQIEAA YREMRRGDAEEDPRFKQPIPYVVIKREDEVFLYERLAGGGESRLHNKLSLGFGGHMNA IEGAASFAEVLKLNTDRELEEELQINEEDKQAIVTLGLINDDENSVGKVHIGILSALQ LKPGAQVEVKEKEQIAGKWMKVSELKQDDIYNRLETWSQFVVDILE*" /label="ymaB CDS" gene 1608419..1609039 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /label="ymaB gene" downshifts 1609020 /Source="Nicolas_upshifts" /id="D941" /incds=0 /nref=130 /ntot=257 /MaxReadThrough="4.3301" /MaxDrop="6.0751" /score="31.3992458" /energy="-16.3" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-35" /isTUend="FALSE" /label="downshifts" promotor_-35 1609055..1609059 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1609077..1609444 /Source="Nicolas_S_feature" /locus_tag="new_1872786_1873153" /HighExp="dia15, G180, H2O2, G135, G150, Diami, Paraq, Oxctl, LBGexp, C30" /AntisenseName="cwlC" /AntisenseCor="-8.9131707018362205E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.231, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S623" upshifts 1609077 /Source="Nicolas_upshifts" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1609081..1609098 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1609087) /Source="Nicolas_upshifts" /id="D942" /incds=0 /nref=1 /ntot=53 /MaxReadThrough="7.25519" /MaxDrop="4.6417" /score="9.14776993" /energy="-8.9" /TU="U1390" /idTUdmin="U1390" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS complement(1609103..1609870) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /EC_number="3.5.1.28" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10515909, 10945275, 10974124, 11375403, 16042392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10945275, 10974124, 11375403, 16042392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (sporulation-specific)" /protein_id="NP_389623.2" /db_xref="EnsemblGenomes-Gn:BSU17410" /db_xref="EnsemblGenomes-Tr:CAB13625" /db_xref="GOA:Q06320" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="PDB:1X60" /db_xref="SubtiList:BG10825" /db_xref="UniProtKB/Swiss-Prot:Q06320" /translation="MVKIFIDPGHGGSDPGATGNGLQEKTLTLQIALALRTILTNEYE GVSLLLSRTSDQYVSLNDRTNAANNWGADFFLSIHVNSGGGTGFESYIYPDVGAPTTT YQSTIHSEVIQAVDFADRGKKTANFHVLRESAMPALLTENGFIDTVSDANKLKTSSFI QSLARGHANGLEQAFNLKKTSSSGLYKVQIGAFKVKANADSLASNAEAKGFDSIVLLK DGLYKVQIGAFSSKDNADTLAARAKNAGFDAIVILES*" /label="cwlC CDS" gene complement(1609103..1609870) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /label="cwlC gene" promotor_-10 complement(1609879..1609898) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1609902) /Source="Nicolas_upshifts" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1609911..1609920) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1610024..1610029 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1610045..1610063 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1610045 /Source="Nicolas_upshifts" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1610327..1610332 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-35" promotor_-10 1610349..1610367 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-10" S_feature 1610353..1610493 /Source="Nicolas_S_feature" /locus_tag="new_1874062_1874202" /HighExp="S4, S5, S6, S8, S3, B60, LoTm, S7, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.777" /TUlongSig="NA" /TUlongPSig="NA" /label="S624" upshifts 1610353 /Source="Nicolas_upshifts" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="upshifts" CDS 1610494..1611462 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8464402, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="mother cell sporulation ATPase" /protein_id="NP_389624.2" /db_xref="EnsemblGenomes-Gn:BSU17420" /db_xref="EnsemblGenomes-Tr:CAB13626" /db_xref="GOA:P27643" /db_xref="InterPro:IPR000641" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR014232" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11039" /db_xref="UniProtKB/Swiss-Prot:P27643" /translation="MLERAVTYKNNGQINIILNGQKQVLTNAEAEAEYQAALQKNEAK HGILKEIEKEMSALVGMEEMKRNIKEIYAWIFVNQKRAEQGLKVGKQALHMMFKGNPG TGKTTVARLIGKLFFEMNVLSKGHLIEAERADLVGEYIGHTAQKTRDLIKKSLGGILF IDEAYSLARGGEKDFGKEAIDTLVKHMEDKQHEFILILAGYSREMDHFLSLNPGLQSR FPISIDFPDYSVTQLMEIAKRMIDEREYQLSQEAEWKLKDYLMTVKSTTSPIKFSNGR FVRNVIEKSIRAQAMRLLMGDQYLKSDLMTIKSQDLSIKEEASGSA*" /label="spoVK CDS" gene 1610494..1611462 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /label="spoVK gene" downshifts 1611431 /Source="Nicolas_upshifts" /id="D943" /incds=0 /nref=5 /ntot=41 /MaxReadThrough="2.7881" /MaxDrop="5.20495" /score="22.9164064" /energy="-15.5" /TU="U1392" /idTUdmin="U1392" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-35 1611526..1611534 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-35" upshifts 1611541 /Source="Nicolas_upshifts" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="upshifts" promotor_-10 1611545..1611564 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-10" CDS 1611595..1612857 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19824612, 26458047, 26733579, 26951678, 27398305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-splitting GTPase (also ATPase, rescuingstalled ribosomes, E-site binding)" /protein_id="NP_389625.2" /db_xref="EnsemblGenomes-Gn:BSU17430" /db_xref="EnsemblGenomes-Tr:CAB13627" /db_xref="GOA:P94478" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016496" /db_xref="InterPro:IPR025121" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030394" /db_xref="InterPro:IPR032305" /db_xref="SubtiList:BG12263" /db_xref="UniProtKB/Swiss-Prot:P94478" /translation="MNEQETIQEKAILVGCQLPHITDEHFENSMEELASLTKTADGKV LTSVTQKRNRADAATYIGKGKVEELKALVEELEADLLIFNDELSPSQLKSLATAIEVK MIDRTQLILDIFAKRARTREGKLQIELAQLQYALPRLTGQGINLSRQGGGIGARGPGE TKLETDRRHIRNRIHEINTQLSTVIRHRSRYRERRKKNGVLQIALVGYTNAGKSTWFN RLTSADSYEEDLLFATLDPMTRKMVLPSGYSVLLSDTVGFIQDLPTTLIAAFRSTLEE VKEADLILHLIDSSNEDYAGHEKTVLRLLEELEADDIPMLTAYNKRDQKLPDFIPTAG RDHIMVSAKFEDDAAAFKEAIQRYLRQELLTSFEAHVPASEGKLLSRIKSETMVDRFY FNEENEQYDISGYVQEEQSIIGELKKYM*" /label="hflX CDS" gene 1611595..1612857 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /label="hflX gene" CDS 1612875..1614140 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 24610841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_389626.2" /db_xref="EnsemblGenomes-Gn:BSU17440" /db_xref="EnsemblGenomes-Tr:CAB13628" /db_xref="GOA:P94479" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR009651" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12264" /db_xref="UniProtKB/Swiss-Prot:P94479" /translation="MFDTLTHGELLKKTAMEVEADIAGIHKQIEEISERNEWRVLQSY RKHKVSDTHFTPSTGYGYDDIGRDTLESIYADVFGGEAGLVRPQIISGTHAISIALFG VLRPGDELLYITGKPYDTLEEIVGVRGGENAGSLKDFQIGYNAVDLTKDGKIDYDAVA AAINPKTKVIGIQRSKGYANRPSFLISEIKEMIRFVKEINENLIVFVDNCYGEFVEEL EPCHVGADLMAGSLIKNPGGGLAKTGGYLVGKAKWIEACSYRMTSPGIGREAGASLYS LQEMYQGFFLAPHVVSQSLKGAVFTARFLEKLGFTSNPKWDAKRTDLIQSVEFSDREK MIAFCQAIQFASPINAHVTPYPAYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYV AYVQGGLTYSHVKNAICSAVDSLMQKQLI*" /label="ynbB CDS" gene 1612875..1614140 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /label="ynbB gene" promotor_-35 1614188..1614195 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1614210..1614229 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1614222 /Source="Nicolas_upshifts" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="upshifts" CDS 1614250..1614657 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (nitrogen metabolism)" /protein_id="NP_389627.1" /db_xref="EnsemblGenomes-Gn:BSU17450" /db_xref="EnsemblGenomes-Tr:CAB13629" /db_xref="GOA:P37582" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4R4E" /db_xref="SubtiList:BG10424" /db_xref="UniProtKB/Swiss-Prot:P37582" /translation="MSDNIRRSMPLFPIGIVMQLTELSARQIRYYEENGLIFPARSEG NRRLFSFHDVDKLLEIKHLIEQGVNMAGIKQILAKAEAEPEQKQNEKTKKPMKHDLSD DELRQLLKNELMQAGRFQRGNTFRQGDMSRFFH*" /label="glnR CDS" gene 1614250..1614657 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /label="glnR gene" downshifts complement(1614256) /Source="Nicolas_upshifts" /id="D944" /incds=0 /nref=2 /ntot=82 /MaxReadThrough="1.78139" /MaxDrop="3.45896" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3816 /isTUend="FALSE" /label="downshifts" misc_feature 1614638..1614656 /Source="Nicolas_upshift_promotors" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1614663 /Source="Nicolas_upshifts" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1614716) /Source="Nicolas_upshifts" /id="D945" /incds=0 /nref=1 /ntot=72 /MaxReadThrough="1.70567" /MaxDrop="3.42395" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3356 /isTUend="FALSE" /label="downshifts" CDS 1614716..1616050 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /EC_number="6.3.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine synthetase" /protein_id="NP_389628.1" /db_xref="EnsemblGenomes-Gn:BSU17460" /db_xref="EnsemblGenomes-Tr:CAB13630" /db_xref="GOA:P12425" /db_xref="InterPro:IPR001637" /db_xref="InterPro:IPR004809" /db_xref="InterPro:IPR008146" /db_xref="InterPro:IPR008147" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR027302" /db_xref="InterPro:IPR027303" /db_xref="InterPro:IPR036651" /db_xref="PDB:2FWX" /db_xref="PDB:4LNF" /db_xref="PDB:4LNI" /db_xref="PDB:4LNK" /db_xref="PDB:4LNN" /db_xref="PDB:4LNO" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG10425" /db_xref="UniProtKB/Swiss-Prot:P12425" /translation="MAKYTREDIEKLVKEENVKYIRLQFTDILGTIKNVEIPVSQLGK ALDNKVMFDGSSIEGFVRIEESDMYLYPDLNTFVIFPWTAEKGKVARFICDIYNPDGT PFEGDPRNNLKRILKEMEDLGFSDFNLGPEPEFFLFKLDEKGEPTLELNDKGGYFDLA PTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAGAVRSCDDIQTFKLVV KTIARKHGLHATFMPKPLFGVNGSGMHCNLSLFKNGVNAFFDENADLQLSETAKHFIA GIVKHATSFTAVTNPTVNSYKRLVPGYEAPCYVAWSAQNRSPLIRIPASRGISTRVEV RSVDPAANPYLALSVLLAAGLDGIKNKLEAPAPIDRNIYVMSKEERMENGIVDLPATL AEALEEFKSNEVMVKALGEHLFEHFIEAKEIEWDMFRTQVHPWEREQYMSQY*" /label="glnA CDS" gene 1614716..1616050 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /label="glnA gene" downshifts 1616027 /Source="Nicolas_upshifts" /id="D946" /incds=0 /nref=266 /ntot=287 /MaxReadThrough="5.53201" /MaxDrop="7.28613" /score="29.7599306" /energy="-16.4" /TU="U1394,U1395" /idTUdmin="U1393" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature 1616072..>1616121 /Source="Nicolas_S_feature" /locus_tag="new_1879781_1880041" /HighExp="Cold, BT, LBGtran, G135, G180, Etha, G150, LBGexp, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S625" SCAR 1616121..1616122 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs04" S_feature <1616122..1616874 /Source="Nicolas_S_feature" /locus_tag="new_1886528_1887351" /HighExp="Lbstat, M0t90, S8, C30, Pyr, Lbtran, M40t90, S1, M/G, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S631" promotor_-10 complement(1616214..1616232) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1616232) /Source="Nicolas_upshifts" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1616248..1616253) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1616875..1618266 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16684115, 16850406, 17183216, 20406496; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+-xyloside symporter" /protein_id="NP_389639.2" /db_xref="EnsemblGenomes-Gn:BSU17570" /db_xref="EnsemblGenomes-Tr:CAB13641" /db_xref="GOA:P94488" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12262" /db_xref="UniProtKB/Swiss-Prot:P94488" /translation="MLSENVKKISMVEKVGYASGDFACNLIYATVSTYLLFFYTDVFG LSAAAAGTMFLVVRIIDALADPFIGTIVDRTNSRFGRFRPYLLFGAFPFVILAILCFT TPDFSDMGKLIYAYITYVGLSLTYTTINVPYGALTSAMTRNNQEVVSITSVRMLFANL GGLVVAFFVPLLAAYLSDTSGNESLGWQLTMGILGMIGGCLLIFCFKSTKERVTLQKS EEKIKFTDIFEQFRVNRPLVVLSIFFIIIFGVNSISNSVGIYYVTYNLEREDLVKWYG LIGSLPALVILPFIPRLHQFLGKKKLLNYALLLNIIGLLALLFVPPSNVYLILVCRLI AAAGSLTAGGYMWALIPETIEYGEYRTGKRMGGLIYAIIGFFFKFGMALGGVVPGLVL DKFGYVANQAQTPAALMGILITTTIIPVFLLVLALIDINFYNLDEKKYKNMVRELENR DKVYLDHIDDFKA*" /label="xynP CDS" gene 1616875..1618266 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /label="xynP gene" CDS 1618297..1619898 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /EC_number="3.2.1.37" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2440680, 6413490, 7816035, 9286998, 9973552, 16684115, 28066362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylan beta-1,4-xylosidase" /protein_id="NP_389640.2" /db_xref="EnsemblGenomes-Gn:BSU17580" /db_xref="EnsemblGenomes-Tr:CAB13642" /db_xref="GOA:P94489" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="PDB:1YIF" /db_xref="SubtiList:BG11987" /db_xref="UniProtKB/Swiss-Prot:P94489" /translation="MKITNPVLKGFNPDPSICRAGEDYYIAVSTFEWFPGVQIHHSKD LVNWHLVAHPLQRVSQLDMKGNPNSGGVWAPCLSYSDGKFWLIYTDVKVVDGAWKDCH NYLVTCETINGDWSEPIKLNSSGFDASLFHDTDGKKYLLNMLWDHRIDRHSFGGIVIQ EYSDKEQKLIGKPKVIFEGTDRKLTEAPHLYHIGNYYYLLTAEGGTRYEHAATIARSA NIEGPYEVHPDNPILTSWHDPGNPLQKCGHASIVQTHTDEWYLAHLTGRPIHPDDDSI FQQRGYCPLGRETAIQKLYWKDEWPYVVGGKEGSLEVDAPSIPETIFEATYPEVDEFE DSTLNINFQTLRIPFTNELGSLTQAPNHLRLFGHESLTSTFTQAFVARRWQSLHFEAE TAVEFYPENFQQAAGLVNYYNTENWTALQVTHDEELGRILELTICDNFSFSQPLNNKI VIPREVKYVYLRVNIEKDKYYYFYSFNKEDWHKIDIALESKKLSDDYIRGGGFFTGAF VGMQCQDTSGNHIPADFRYFRYKEK*" /label="xynB CDS" gene 1618297..1619898 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /label="xynB gene" S_feature complement(1618413..1618718) /Source="Nicolas_S_feature" /locus_tag="new_1888890_1889195_c" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, S4, B36, BC" /AntisenseName="xynB" /AntisenseCor="6.2527836498644102E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S632" promotor_-10 complement(1618713..1618732) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1618718) /Source="Nicolas_upshifts" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1618746..1618754) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1619896 /Source="Nicolas_upshifts" /id="D951" /incds=0 /nref=2 /ntot=53 /MaxReadThrough="1.32947" /MaxDrop="3.8449" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1400" /TUdmin=3190 /isTUend="FALSE" /label="downshifts" CDS complement(1620035..1621189) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1588910, 1719948, 2544559, 7559331; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389641.3" /db_xref="EnsemblGenomes-Gn:BSU17590" /db_xref="EnsemblGenomes-Tr:CAB13643" /db_xref="GOA:P94490" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11986" /db_xref="UniProtKB/Swiss-Prot:P94490" /translation="MDIADQTFVKKVNQKLLLKEILKNSPISRAKLSEMTGLNKSTVS SQVNTLMKESMVFEIGQGQSSGGRRPVMLVFNKKAGYSVGIDVGVDYINGILTDLEGT IVLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIVF TPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIG IGVIINNHLYRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKEK KLSYQDIINLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVILRNSIIESHPMV LNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFLDMITM*" /label="xylR CDS" gene complement(1620035..1621189) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /label="xylR gene" downshifts complement(1620038) /Source="Nicolas_upshifts" /id="D952" /incds=0 /nref=9 /ntot=198 /MaxReadThrough="2.56326" /MaxDrop="4.09398" /score="19.297583" /energy="-7.4" /TU="NA" /idTUdmin="U1405" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1621088..1621266) /Source="Nicolas_S_feature" /locus_tag="new_1891565_1891743_c" /HighExp="dia15, Etha, dia5, dia0, Cold, LBGstat, Lbexp, M0t45, Diami, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S633" promotor_-35 1621234..1621240 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1621249..1621268) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1621250..1621266 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1621260 /Source="Nicolas_upshifts" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1621266) /Source="Nicolas_upshifts" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1621283..1621286) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1621293..1621300 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1621315..1621334 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1621326..1621430 /Source="Nicolas_S_feature" /locus_tag="new_1891803_1891907" /HighExp="dia15, dia0, Lbexp, dia5, B60, Sw, G150, LPhT, Mt0, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S634" upshifts 1621327 /Source="Nicolas_upshifts" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="upshifts" CDS 1621431..1622768 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /EC_number="5.3.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7663444, 8132469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7663444, 8132469; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylose isomerase" /protein_id="NP_389642.2" /db_xref="EnsemblGenomes-Gn:BSU17600" /db_xref="EnsemblGenomes-Tr:CAB13644" /db_xref="GOA:P0CI80" /db_xref="InterPro:IPR001998" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR013452" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG10806" /db_xref="UniProtKB/Swiss-Prot:P0CI80" /translation="MAQSHSSSINYFGSANKVVYEGKDSTNPLAFKYYNPQEVIGGKT LKEHLRFSIAYWHTFTADGTDVFGAATMQRPWDHYKGMDLAKMRVEAAFEMFEKLDAP FFAFHDRDIAPEGSTLKETNQNLDMIMGMIKDYMRNSGVKLLWNTANMFTNPRFVHGA ATSCNADVFAYAAAQVKKGLETAKELGAENYVFWGGREGYETLLNTDLKFELDNLARF MHMAVDYAKEIGYTGQFLIEPKPKEPTTHQYDTDAATTIAFLKQYGLDNHFKLNLEAN HATLAGHTFEHELRMARVHGLLGSVDANQGHPLLGWDTDEFPTDLYSTTLAMYEILQN GGLGSGGLNFDAKVRRSSFEPDDLIYAHIAGMDAFARGLKVAHKLIEDRVFEDVIQHR YRSFTEGIGLEIIEGRANFHTLEQYALNHKSIKNESGRQEKLKAILNQYILEV*" /label="xylA CDS" gene 1621431..1622768 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /label="xylA gene" S_feature 1622769..1622843 /Source="Nicolas_S_feature" /locus_tag="new_1893246_1893320" /HighExp="dia0, dia15, Sw, Lbexp, dia5, B60, Mt0, M0t45, G150, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S635" downshifts 1622800 /Source="Nicolas_upshifts" /id="D953" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="4.89699" /MaxDrop="3.40404" /score="13.0570501" /energy="-10.2" /TU="U1406" /idTUdmin="U1406" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" CDS 1622919..1624418 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /EC_number="2.7.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1660563, 8866023, 27467131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylulose kinase" /protein_id="NP_389643.1" /db_xref="EnsemblGenomes-Gn:BSU17610" /db_xref="EnsemblGenomes-Tr:CAB13645" /db_xref="GOA:P39211" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006000" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10807" /db_xref="UniProtKB/Swiss-Prot:P39211" /translation="MKYVIGIDLGTSAVKTILVNQNGKVCAETSKRYPLIQEKAGYSE QNPEDWVQQTIEALAELVSISNVQAKDIDGISYSGQMHGLVLLDQDRQVLRNAILWND TRTTPQCIRMTEKFGDHLLDITKNRVLEGFTLPKMLWVKEHEPELFKKTAVFLLPKDY VRFRMTGVIHTEYSDAAGTLLLHITRKEWSNDICNQIGISADICPPLVESHDCVGSLL PHVAAKTGLLEKTKVYAGGADNACGAIGAGILSSGKTLCSIGTSGVILSYEEEKERDF KGKVHFFNHGKKDSFYTMGVTLAAGYSLDWFKRTFAPNESFEQLLQGVEAIPIGANGL LYTPYLVGERTPHADSSIRGSLIGMDGAHNRKHFLRAIMEGITFSLHESIELFREAGK SVHTVVSIGGGAKNDTWLQMQADIFNTRVIKLENEQGPAMGAAMLAAFGSGWFESLEE CAEQFIREAAAFYPKAQNVQKYKTLFDLYKNIYTHTKDLNTALKSFRKN*" /label="xylB CDS" gene 1622919..1624418 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /label="xylB gene" S_feature 1624419..1624734 /Source="Nicolas_S_feature" /locus_tag="new_1894896_1895211" /HighExp="dia0, dia15, Lbexp, dia5, Mt0, M0t45, G150, Etha, Diami, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.51323200000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S636" downshifts 1624692 /Source="Nicolas_upshifts" /id="D954" /incds=0 /nref=60 /ntot=197 /MaxReadThrough="0.61776" /MaxDrop="5.13425" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1624901..1625536) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11584000" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11584000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA nuclease, lipoprotein (phage origin)" /protein_id="NP_389644.1" /db_xref="EnsemblGenomes-Gn:BSU17620" /db_xref="EnsemblGenomes-Tr:CAB13646" /db_xref="GOA:P94492" /db_xref="InterPro:IPR002071" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR035437" /db_xref="SubtiList:BG12265" /db_xref="UniProtKB/Swiss-Prot:P94492" /translation="MKKILISMIAIVLSITLAACGSNHAAKNHSDSNGTEQVSQDTHS NEYNQTEQKAGTPHSKNQKKLVNVTLDRAIDGDTIKVIYNGKKDTVRYLLVDTPETKK PNSCVQPYGEDASKRNKELVNSGKLQLEFDKGDRRDKYGRLLAYVYVDGKSVQETLLK EGLARVAYVYEPNTKYIDQFRLDEQEAKSDKLSIWSKSGYVTNRGFNGCVK*" /label="yncB CDS" gene complement(1624901..1625536) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /label="yncB gene" promotor_-10 complement(1625573..1625592) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1625582) /Source="Nicolas_upshifts" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1625607..1625614) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1625724..1625731 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1625746..1625765 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1625748..1625946 /Source="Nicolas_S_feature" /locus_tag="new_1896225_1896423" /HighExp="T0.30H, Lbtran, T1.0H, M9-stat, M0t90, T1.30H, M40t90, T2.0H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S637" upshifts 1625748 /Source="Nicolas_upshifts" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="upshifts" CDS 1625947..1627362 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22900538, 23569278; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar transporter" /protein_id="NP_389645.2" /db_xref="EnsemblGenomes-Gn:BSU17630" /db_xref="EnsemblGenomes-Tr:CAB13647" /db_xref="GOA:P94493" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12266" /db_xref="UniProtKB/Swiss-Prot:P94493" /translation="MDMNEHRNRRLKLIMISATFGGLLFGYDTGVINGALPFMARPDQ LDLTPVTEGLVTSILLLGAAFGALLCGRLADRYGRRKMILNLSFLFFLASLGTALAPN VFIMAVFRFLLGLAVGGASAMVPAFLAEMAPHEKRGRMVTQNELMIVGGQFLAYVFNA ILGVTMANTGHVWRYMLVICAVPAIMLFASMLKVPESPRWLISKGKNSEALRVLKQIR EDKRAEAECREIQEAVEKDTALEKASLKDFSTPWLRRLLWIGIGVAIVNQITGVNSIM YYGTQILKESGFGTKAALIANIGNGLISVIAVIFGIWLVGKVRRRPILLIGLAGTTTA LLLIAIFSIVLDGSMALPYVVLSLTVLFLAFMQGCVGPVTWLVIAEIFPQRLRGLGSG ISVFFLWILNFVIGFAFPILLSSVGLSFTFFIFVALGVLAIGFVYKFMPETKGRTLEE LEEHFRSRHDHNTPEQSVIEV*" /label="yncC CDS" gene 1625947..1627362 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /label="yncC gene" downshifts 1627352 /Source="Nicolas_upshifts" /id="D955" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="0.90595" /MaxDrop="4.35189" /score="15.579587" /energy="-8.6" /TU="NA" /idTUdmin="U1408" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1627455) /Source="Nicolas_upshifts" /id="D956" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="1.08869" /MaxDrop="5.39832" /score="24.3759796" /energy="-9.3" /TU="NA" /idTUdmin="U1409" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1627464..1628648) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /EC_number="5.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10348844, 18399999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10348844, 18399999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine racemase (minor activity)" /protein_id="NP_389646.1" /db_xref="EnsemblGenomes-Gn:BSU17640" /db_xref="EnsemblGenomes-Tr:CAB13648" /db_xref="GOA:P94494" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="PDB:5IRP" /db_xref="SubtiList:BG12267" /db_xref="UniProtKB/Swiss-Prot:P94494" /translation="MIKLCREVWIEVNLDAVKKNLRAIRRHIPHKSKIMAVVKANGYG HGSIEVARHALEHGASELAVASVEEGIVLRKAGITAPILVLGFTSLSCVKKSAAWNIT LSAFQVDWMKEANEILEKEASANRLAIHINVDTGMGRLGVRTKEELLEVVKALKASKF LRWTGIFTHFSTADEPDTTLTKLQHEKFISFLSFLKKQGIELPTVHMCNTAAAIAFPE FSADMIRLGIGLYGLYPSAYIKQLNLVKLEPALSLKARIAYVKTMRTEPRTVSYGATY IAEPNEVIATLPIGYADGYSRALSNRGFVLHRGKRVPVAGRVTMDMIMVSLGENGEGK QGDEVVIYGKQKGAEISVDEVAEMLNTINYEVVSTLSRRIPRFYIRDGEIFKVSTPVL YV*" /label="alrB CDS" gene complement(1627464..1628648) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /label="alrB gene" S_feature complement(1628649..1628728) /Source="Nicolas_S_feature" /locus_tag="new_1899126_1899205_c" /HighExp="S4, S5, S3, S6, S7, B36, BT, S8, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.908" /TUlongSig="NA" /TUlongPSig="NA" /label="S638" promotor_-10 complement(1628721..1628739) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1628732) /Source="Nicolas_upshifts" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1628755..1628760) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1629040..1629047 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1629062..1629081 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1629070 /Source="Nicolas_upshifts" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1629112..1629573 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative prophage protein" /protein_id="NP_389648.2" /db_xref="EnsemblGenomes-Gn:BSU17650" /db_xref="EnsemblGenomes-Tr:CAB13649" /db_xref="InterPro:IPR020216" /db_xref="SubtiList:BG12268" /db_xref="UniProtKB/Swiss-Prot:P94495" /translation="MNRGVSFQIPNEYGNFLWRILQPVEIANYRWQTSGESYFVVEGE LDDEELFHDYEIVEGAVFEQQLKTNQYYTIFVELKAFPYGKMVNQVNTYEEFADSDCE LVLLIADNSYVSIYCKNKNIIEKLYFNALQHDFEDVQFITDENDTRTSLTV*" /label="yncE CDS" gene 1629112..1629573 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /label="yncE gene" CDS 1629603..1630037 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /EC_number="3.6.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11375514, 15939294, 16908222, 17169987, 21358047, 23897460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11375514, 15939294, 16908222, 17169987, 21358047, 23897460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="deoxyuridine 5'-triphosphate pyrophosphatase (phage origin)" /protein_id="NP_389649.1" /db_xref="EnsemblGenomes-Gn:BSU17660" /db_xref="EnsemblGenomes-Tr:CAB13650" /db_xref="GOA:O31801" /db_xref="InterPro:IPR029054" /db_xref="InterPro:IPR033704" /db_xref="InterPro:IPR036157" /db_xref="PDB:2XCD" /db_xref="PDB:2XCE" /db_xref="PDB:4AOO" /db_xref="PDB:4AOZ" /db_xref="PDB:4APZ" /db_xref="PDB:4B0H" /db_xref="SubtiList:BG13437" /db_xref="UniProtKB/Swiss-Prot:O31801" /translation="MTMQIKIKYLDETQTRISKIEQGDWIDLRAAEDVTIKKDEFKLV PLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDT EIKKGDRICQFRIMKKMPAVELVEVEHLGNEDRGGLGSTGTK*" /label="dutA CDS" gene 1629603..1630037 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /label="dutA gene" S_feature complement(1629786..1630091) /Source="Nicolas_S_feature" /locus_tag="new_1900263_1900568_c" /HighExp="LoTm, S5, T5.0H, S8, T4.0H, S4, S7, T3.30H, Cold, T-4.40H" /AntisenseName="yncF" /AntisenseCor="-0.40042805081531202" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S639" downshifts 1629884 /Source="Nicolas_upshifts" /id="D957" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.18195" /MaxDrop="2.2821" /score="0.171090809" /energy="-9.3" /TU="U1410" /idTUdmin="U1408" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" S_feature 1630038..1631134 /Source="Nicolas_S_feature" /locus_tag="new_1900515_1901611" /HighExp="S8, G150, G180, dia0, G135, UNK1, MG 15, Lbexp, Fru, S7" /AntisenseName="cotU" /AntisenseCor="-0.266961200384908" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S640" S_feature complement(1630093..1630378) /Source="Nicolas_S_feature" /locus_tag="new_1900570_1900855_c" /HighExp="LoTm, dia5, dia15, T3.30H, T3.0H, T-4.40H, T4.0H, T5.0H, T-3.40H, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25207000000000002" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S641" downshifts complement(1630136) /Source="Nicolas_upshifts" /id="D958" /incds=0 /nref=2 /ntot=95 /MaxReadThrough="4.29622" /MaxDrop="2.9464" /score="11.6697365" /energy="-9.7" /TU="U1411" /idTUdmin="U1411" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1630373..1630392) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1630378) /Source="Nicolas_upshifts" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1630404..1630409) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1630640) /Source="Nicolas_upshifts" /id="D959" /incds=0 /nref=17 /ntot=130 /MaxReadThrough="2.07509" /MaxDrop="8.56023" /score="11.6697365" /energy="-9.7" /TU="NA" /idTUdmin="U1412" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1630640..1630900) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12562816, 18065538, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 18065538, 20023017; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389650.1" /db_xref="EnsemblGenomes-Gn:BSU17670" /db_xref="EnsemblGenomes-Tr:CAB13651" /db_xref="GOA:O31802" /db_xref="SubtiList:BG13471" /db_xref="UniProtKB/Swiss-Prot:O31802" /translation="MGYYKKYKEEYYTWKKTYYKKYYDNDKKHYDCDKYYDHDKKHYD YDKKYDDHDKKYYDDHDYHYEKKYYDDDDHYYDFVESYKKHH*" /label="cotU CDS" gene complement(1630640..1630900) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /label="cotU gene" promotor_-10 complement(1630921..1630940) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1630931) /Source="Nicolas_upshifts" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1630953..1630962) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1631135..1631260 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein (putative phage origin)" /db_xref="PSEUDO:CAX52624.1" /translation="MNVMVKIQELYDVIFHTAFEGFRVRHQKQTAKPARNRSYKE*" /label="ynzJ CDS" gene 1631135..1631260 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /pseudo /label="ynzJ gene" S_feature 1631261..1631377 /Source="Nicolas_S_feature" /locus_tag="new_1901738_1901854" /HighExp="G180, G135, G150, dia0, UNK1, S8, Lbexp, C90, MG 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S642" CDS 1631304..1631468 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein from phage origin" /protein_id="YP_009513957.1" /translation="MKLERIYFKESPIAHGQMTIDIEVKYNALNQKKLLEDLMCLDNF QFGIHKHLTI*" /label="conserved hypothetical protein from phage origin CDS" gene 1631304..1631468 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /label="gene" promotor_-35 1631352..1631361 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1631375..1631394 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1631379..1631689 /Source="Nicolas_S_feature" /locus_tag="new_1901856_1902166" /HighExp="S7, S6, S8, S5, BT, G/S, Pyr, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.585202" /TUshortSig="SigK, SigA" /TUshortPSig="0.935, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S643" upshifts 1631379 /Source="Nicolas_upshifts" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1631670..1631677 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1631691..1631710 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1631691 /Source="Nicolas_upshifts" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1631742..1632581 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:416889, 418407, 9648749, 10091656, 10574451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 416889, 418407, 9648749, 10091656, 10574451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase A (phage origin)" /protein_id="NP_389651.1" /db_xref="EnsemblGenomes-Gn:BSU17680" /db_xref="EnsemblGenomes-Tr:CAB13652" /db_xref="GOA:P0CI79" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="PDB:1B02" /db_xref="PDB:1BKO" /db_xref="PDB:1BKP" /db_xref="PDB:1BSF" /db_xref="PDB:1BSP" /db_xref="SubtiList:BG11190" /db_xref="UniProtKB/Swiss-Prot:P0CI79" /translation="MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVI SKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDG TIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTP CVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNI GDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFE VAV*" /label="thyA CDS" gene 1631742..1632581 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /label="thyA gene" promotor_-10 complement(1631764..1631783) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1631785) /Source="Nicolas_upshifts" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1631798..1631801) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1632541 /Source="Nicolas_upshifts" /id="D960" /incds=0 /nref=6 /ntot=143 /MaxReadThrough="4.34299" /MaxDrop="3.3234" /score="1.39203037" /energy="-7.7" /TU="U1410,U1414" /idTUdmin="U1413" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts complement(1632687) /Source="Nicolas_upshifts" /id="D961" /incds=0 /nref=6 /ntot=150 /MaxReadThrough="3.28185" /MaxDrop="3.73135" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1417" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature complement(1632688..1632994) /Source="Nicolas_S_feature" /locus_tag="new_1903165_1903471_c" /HighExp="LBGstat, Lbstat, LoTm, B60, LPhT, M9-stat, T1.30H, B36, nit, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99924299999999999" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S644" CDS complement(1632704..1632991) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513958.1" /translation="MEHTGHSSFLQLFCLNLTLIRVEIGMKYEKTSLFGMILVIVALL ISIYFMCNTNALIPAGYDLAIHGIVISRTVMIAFTLYLVSKLGYFLLNKKD*" /label="conserved protein of unknown function CDS" gene complement(1632704..1632991) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /label="gene" downshifts complement(1632731) /Source="Nicolas_upshifts" /id="D962" /incds=0 /nref=2 /ntot=85 /MaxReadThrough="3.82042" /MaxDrop="6.47995" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1418" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1632818..1632826 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1632840..1632859 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1632842 /Source="Nicolas_upshifts" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="upshifts" S_feature 1632853..1633013 /Source="Nicolas_S_feature" /locus_tag="new_1903330_1903490" /HighExp="S8, S6, S7, BT, S5, S4, S3, Pyr, G/S, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S645" downshifts 1632985 /Source="Nicolas_upshifts" /id="D963" /incds=0 /nref=13 /ntot=53 /MaxReadThrough="1.26429" /MaxDrop="5.75919" /score="7.35184753" /energy="-11.1" /TU="NA" /idTUdmin="U1416" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1633034..1633756) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_389652.2" /db_xref="EnsemblGenomes-Gn:BSU17690" /db_xref="EnsemblGenomes-Tr:CAB13653" /db_xref="GOA:O31803" /db_xref="InterPro:IPR029143" /db_xref="PDB:4HFS" /db_xref="SubtiList:BG13438" /db_xref="UniProtKB/Swiss-Prot:O31803" /translation="MVKKVLIAGAVGTAVLFGTLSSGIPGLPAADAQVAKAASELPNG IGGRVYLNSTGAVFTAKIVLPETVKNNDSVSTPYIYSGFRATSGTEADIGLQYSKQYN VWKPLMKVGSKNEETYIEGKDKFTYNKGFRPGSTVQMTIYKNLSGNTRMTLWGTNNDG YTGRIITEIQGTNIGTISKWKTLATAAVSYESQRDAIKATFSTSFNNITIDNKAVTPV VDTQDFAKVSVAGNNVTISVNK*" /label="yncM CDS" gene complement(1633034..1633756) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /label="yncM gene" downshifts complement(1633039) /Source="Nicolas_upshifts" /id="D964" /incds=0 /nref=31 /ntot=133 /MaxReadThrough="5.62856" /MaxDrop="4.3658" /score="0.425084384" /energy="-11.1" /TU="U1417" /idTUdmin="U1418" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1633781..1633800) /Source="Nicolas_upshift_promotors" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1633789) /Source="Nicolas_upshifts" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1633791..1633915) /Source="Nicolas_S_feature" /locus_tag="new_1904268_1904392_c" /HighExp="H2O2, dia15, S8, G180, G150, Paraq, Oxctl, LBGstat, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S646" CDS complement(1633916..1634272) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function (phage origin)" /protein_id="YP_003097731.1" /db_xref="EnsemblGenomes-Gn:BSU17699" /db_xref="EnsemblGenomes-Tr:CAX52625" /db_xref="GOA:C0H417" /db_xref="InterPro:IPR025621" /db_xref="UniProtKB/Swiss-Prot:C0H417" /translation="MYRNIVFYLILLCLFISVVMKSFEVIRTIANVICFIFVLLYFKD EMKTYSRKALAILSICFLFLVGICAFIILQGQTLMKRHLFFTGLETIAGILLIIVSLS ICTFILRKISNRLKRM*" /label="ynzK CDS" gene complement(1633916..1634272) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /label="ynzK gene" promotor_-10 complement(1634296..1634315) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1634313) /Source="Nicolas_upshifts" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1634331..1634335) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1634512) /Source="Nicolas_upshifts" /id="D965" /incds=0 /nref=58 /ntot=194 /MaxReadThrough="0.902090000000001" /MaxDrop="9.00312" /score="34.0680178" /energy="-10.8" /TU="NA" /idTUdmin="U1419" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1634518..1634718) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389653.2" /db_xref="EnsemblGenomes-Gn:BSU17700" /db_xref="EnsemblGenomes-Tr:CAB13654" /db_xref="GOA:P07790" /db_xref="SubtiList:BG10492" /db_xref="UniProtKB/Swiss-Prot:P07790" /translation="MGYYKKYKEEYYTVKKTYYKKYYEYDKKDYDCDYDKKYDDYDKK YYDHDKKDYDYVVEYKKHKKHY*" /label="cotC CDS" gene complement(1634518..1634718) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /label="cotC gene" downshifts 1634701 /Source="Nicolas_upshifts" /id="D966" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="1.37504" /MaxDrop="5.08099" /score="-4.2739983" /energy="-8" /TU="NA" /idTUdmin="U1416" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1634740..1634759) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1634752) /Source="Nicolas_upshifts" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1634772..1634781) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1634893..1635081) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10974125, 11007775, 26239117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974125, 11007775, 26239117; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_389654.1" /db_xref="EnsemblGenomes-Gn:BSU17710" /db_xref="EnsemblGenomes-Tr:CAB13655" /db_xref="GOA:O31804" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG13464" /db_xref="UniProtKB/Swiss-Prot:O31804" /translation="MELSFTKILVILFVGFLVFGPDKLPALGRAAGKALSEFKQATSG LTQDIRKNDSENKEDKQM*" /label="tatAC CDS" gene complement(1634893..1635081) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /label="tatAC gene" downshifts complement(1634909) /Source="Nicolas_upshifts" /id="D967" /incds=0 /nref=213 /ntot=254 /MaxReadThrough="3.38696" /MaxDrop="6.07983" /score="8.58114058" /energy="-11" /TU="U1420,U1421" /idTUdmin="U1420" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" misc_feature complement(1635050..1635057) /Source="Nicolas_upshift_promotors" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1635063) /Source="Nicolas_upshifts" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1635110..1635129) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1635128) /Source="Nicolas_upshifts" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1635144..1635151) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1635160..1635297 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513959.1" /translation="MNILKPAQRRIHKTAAAEYNVQCHLPKKQEAGWINYVALPEMIQ T*" /label="hypothetical protein CDS" gene 1635160..1635297 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /label="gene" promotor_-35 1635191..1635196 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1635211..1635229 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1635229..1635331 /Source="Nicolas_S_feature" /locus_tag="new_1905706_1905808" /HighExp="S3, S4, LoTm, BT, B36, S5, S7, S6, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.35884500000000003" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S647" upshifts 1635229 /Source="Nicolas_upshifts" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="upshifts" CDS 1635332..1635730 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein of unknown function" /protein_id="NP_389655.1" /db_xref="EnsemblGenomes-Gn:BSU17720" /db_xref="EnsemblGenomes-Tr:CAB13656" /db_xref="SubtiList:BG13439" /db_xref="UniProtKB/Swiss-Prot:O31805" /translation="MRFTKVVGFLSVLGLAAVFPLTAQAEKAGTAGAGEWDKLGTYTY TYSSPTVYSTGGDFRVCLSGSTPFSVSLHLYEDDPGDNPDDYVGANYFSPGECHTFGS IGKFVDGSNNKAEFFVTDYSGKSKTVTFYD*" /label="yndA CDS" gene 1635332..1635730 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /label="yndA gene" S_feature 1635731..1636535 /Source="Nicolas_S_feature" /locus_tag="new_1906208_1907012" /HighExp="LoTm, S3, BT, S4, B36, S6, S5, S7, S8, T5.0H" /AntisenseName="yndB" /AntisenseCor="-0.559713635360228" /AntisenseRegPval="-22.9" /CDS_PredictionProba="0.91098199999999996" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S648" CDS complement(1635795..1636229) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /experiment="publication(s) with functional evidences, PMID:20818668, 28160315" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20818668, 28160315; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of stress-related ATPase (flavonoid-sensing)" /protein_id="NP_389656.1" /db_xref="EnsemblGenomes-Gn:BSU17730" /db_xref="EnsemblGenomes-Tr:CAB13657" /db_xref="GOA:O31806" /db_xref="InterPro:IPR013538" /db_xref="InterPro:IPR023393" /db_xref="PDB:2KEW" /db_xref="PDB:2KTE" /db_xref="SubtiList:BG13440" /db_xref="UniProtKB/Swiss-Prot:O31806" /translation="MAQNNENALPDITKSITLEAPIQKVWETVSTSEGIAKWFMPNDF QLKEGQEFHLQSPFGPSPCKVLAVQAPTELSFEWDTEGWVVTFQLEDLGEKTGFTLIH SGWKEPNEVIGKANEKSSVVRGKMDGGWTGIVNERLRKAVEE*" /label="flvS CDS" gene complement(1635795..1636229) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /label="flvS gene" downshifts complement(1635811) /Source="Nicolas_upshifts" /id="D968" /incds=0 /nref=213 /ntot=253 /MaxReadThrough="1.7995" /MaxDrop="6.63594" /score="29.1580701" /energy="-7" /TU="NA" /idTUdmin="U1423" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1636259..1636278) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1636275) /Source="Nicolas_upshifts" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1636292..1636299) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1636536..1636724 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846" /codon_start=1 /transl_table=11 /product="conserved protein involved in spore germination" /protein_id="NP_389657.2" /db_xref="EnsemblGenomes-Gn:BSU17740" /db_xref="EnsemblGenomes-Tr:CAB13658" /db_xref="SubtiList:BG13465" /db_xref="UniProtKB/Swiss-Prot:O31807" /translation="MLGKIKAAIDNSPGKPARILVSEKAFQQLEEEMRFVYVSKPKTI MGIPVEVSDQAESFKLEF*" /label="ynzB CDS" gene 1636536..1636724 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /label="ynzB gene" S_feature 1636725..1636810 /Source="Nicolas_S_feature" /locus_tag="new_1907202_1907287" /HighExp="LoTm, BT, S4, S6, S3, S8, S7, B36, S5, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S649" downshifts 1636769 /Source="Nicolas_upshifts" /id="D969" /incds=0 /nref=7 /ntot=89 /MaxReadThrough="2.20002" /MaxDrop="4.21414" /score="19.5879917" /energy="-11.9" /TU="NA" /idTUdmin="U1422" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1636839..1636845 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1636857..1637016 /Source="Nicolas_S_feature" /locus_tag="new_1907334_1907493" /HighExp="S8, S4, S6, S7, S5, S3, BT, ferm, LoTm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.95681300000000002" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S650" upshifts 1636857 /Source="Nicolas_upshifts" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1636859..1636870 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1637017..1638579 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10762253, 27208128; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_389658.1" /db_xref="EnsemblGenomes-Gn:BSU17750" /db_xref="EnsemblGenomes-Tr:CAB13659" /db_xref="GOA:O31808" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG13441" /db_xref="UniProtKB/Swiss-Prot:O31808" /translation="MMRWRNNQYKTQKQHKSDYSTAEKQDQDVLTGNIGYDLEHVKRK IGHNGDVHFRELEITQLHVKAALIFVEGLSDQDLINKGLSVLVMNQPNQVSDEISQSG KGILTSKQIKNQIVSIGDVIDSEKISDIVLNVFMGSTALLIDGIPQAFLLGTVKKQNR SIEEPLSEALVRGPRTGFTEELSTNTALLRQQGKNDQLTLQRFEVGTRLKKDLIIAYM NDIADPKVVEEVRKRVRGIEIDHLPESGYVEQLIEDNYLSPFPQVQSTERPDRVISGL MEGRVAILLDGTPFALIVPVTFSMMLQSPEDYYERWFPSSLIRLLRFIAAMITLFAPA LYISFISFHPGLIPTKLAISISGTRQGVPFPSLIEALFMEVAIEILREAGLRLPKPIG PAIGIVGGLIIGEAAVQAGIVSPIMVIVVALTAISSFAIPHYSTGIALRMLRFGAMFC AAVFGLFGVIMYYLLLSSHVVKLKSFGVPYASPAVPYHLKDWKDFVIRMPLLVMKRRP KMMNTDNTKRVK*" /label="yndD CDS" gene 1637017..1638579 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /label="yndD gene" promotor_-10 complement(1637320..1637339) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1637329) /Source="Nicolas_upshifts" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1637354..1637361) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1638609..1639700 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane protein" /protein_id="NP_389659.1" /db_xref="EnsemblGenomes-Gn:BSU17760" /db_xref="EnsemblGenomes-Tr:CAB13660" /db_xref="GOA:O31809" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG13442" /db_xref="UniProtKB/Swiss-Prot:O31809" /translation="MFSPTSKITTAQATIIIINYMLAAGVLTLPRTVTEQTQSPDGWI SVLLGGVLAVIAGMIIAKLSQQYPKETFYEYSRHIVGKWLGHLISIVFITYFLALGAF EVRVMSEIVDFFLLEGTPSWAIIMTVLWIGLYSITQGLDPIARLFEMIFPITVIIFLT IALMSLGIFEINNLRPVLGDGIMPVLRGVKTTNLSFTCSEIMFILVAFMKKPKNAVKA VVIGTGVVTSFYMITMIMVIGALSVEGVVTRTWPGLDLMRSFEIPGLIFERFESFLLV IWIMQLFATFIITFYAASLGVSQVFKKKPLSCMFGLLPVIYILSCMPKNENDVFILGD TVSHIALYIFGALPILLLVISKWRKRGEK*" /label="yndE CDS" gene 1638609..1639700 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /label="yndE gene" CDS 1639690..1640904 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 27208128; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative spore germination lipoprotein" /protein_id="NP_389660.1" /db_xref="EnsemblGenomes-Gn:BSU17770" /db_xref="EnsemblGenomes-Tr:CAB13661" /db_xref="GOA:O31810" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG13443" /db_xref="UniProtKB/Swiss-Prot:O31810" /translation="MKSKLKRQLPAMVIVCLLMICVTGCWSSREIEDLGLTFAIAIDK GKETNTEKELKEEGGSYPKKDNITLTYQFVNEKAAGAGTSGGGGSGQGAQKAYINISE TGDSLQQIGSEVALRRDREVFSPHLKVVVMSEDVLHTFPIDEMLDQFFRDNEIRLSCL VLSAKGEARDALQLKENGEIPAFRLIGLGENEHKVSRILPPMTLAKLIGKLHSGSSFL LQNVVAANGAVKYSGAAVINGKSKKMIGTLNEYETEGITWIRGEGKGGVVKSHDKKSQ QTLAYDINKIKSRIQPIVKGKDISFHVDIESEGDLVENWNTKEALDTQFIDRLETTIE NEVKKIVGQVLKKIQHDYKADVAGFDESFRLTYPHLWKRVKNNWDDTFSKADITYSVN VTITHFGTVKTQ*" /label="yndF CDS" gene 1639690..1640904 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /label="yndF gene" promotor_-35 1640982..1640989 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1641004..1641023 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1641015 /Source="Nicolas_upshifts" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="upshifts" CDS 1641051..1641857 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11737947, 22333191, 27435445" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389661.1" /db_xref="EnsemblGenomes-Gn:BSU17780" /db_xref="EnsemblGenomes-Tr:CAB13662" /db_xref="GOA:O31811" /db_xref="SubtiList:BG13444" /db_xref="UniProtKB/Swiss-Prot:O31811" /translation="MRQKPIYVEIEMKSDLDTLWEYTQNPSLHKEWDLRFSNITYLNS QPCEKQKFLYETRVGFGLKVSGTGETVGVFNKCSSERSSSLAFGSDHPLSLIRHGSGY WKYIQRENGKMTFLTQYQYKTAYGLLGRWIDRLLFRPLLGWATAWSFDALRLWVEQNK HPKRFIRSAIIYVFMCLFFSLFWFYQGFAGVKTSILTGTAEIGLAILWLLPLKRKWII HGVQACIFAGFACLGSEIFMWVLLSVFSAASGALSLQLPSARRTKRKRKK*" /label="yndG CDS" gene 1641051..1641857 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /label="yndG gene" S_feature complement(1641665..1642763) /Source="Nicolas_S_feature" /locus_tag="new_1912142_1913240_c" /HighExp="S8, S6, S7, S5, T0.30H, T2.0H, GM 150, BT, T1.30H, T-4.40H" /AntisenseName="yndH" /AntisenseCor="-0.58089150558713998" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S651" CDS 1641862..1642479 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389662.1" /db_xref="EnsemblGenomes-Gn:BSU17790" /db_xref="EnsemblGenomes-Tr:CAB13663" /db_xref="InterPro:IPR025311" /db_xref="SubtiList:BG13445" /db_xref="UniProtKB/Swiss-Prot:O31812" /translation="MSSIYEKSIINYHLLHPKLQKRYQLDGSHTFSGTGTMSEISGGS FLVRMLLKLGVFFRCFFSERGKDIPFTIQNRTCLLKSQHTGIEWNRTFFFKGKKRFFD ALMIYDEKENRILDFFGKPHLLLSVLTFEASLDGSLTITSGKQWLLICGKRIPLPKWL TGTSEVCETFDEKKNCFTIEVHVQNTILGTLFFYKGTFQEEERES*" /label="yndH CDS" gene 1641862..1642479 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /label="yndH gene" CDS 1642476..1644116 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618455, 15849754, 16850406, 28615734; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389663.1" /db_xref="EnsemblGenomes-Gn:BSU17800" /db_xref="EnsemblGenomes-Tr:CAB13664" /db_xref="GOA:O31813" /db_xref="InterPro:IPR025450" /db_xref="SubtiList:BG13446" /db_xref="UniProtKB/Swiss-Prot:O31813" /translation="MKRNGIVSALCFIGFLAAEAPDISVAEALVLLSILFFVPGIFPF VFRQSPVRAAQFMENGLIQCYPVAAFFAVLALVTEVGGFALIWWMYTVFNALYAILRL WETKIHRIEETSVLFGLIYLAGGGFWFFAYAAHLQIMQFGPLIILLTAVHFHYSAFLI PIFNGLLGRTIRKHRMLYSWITWVILLSPLLIALGITYSKTLDVIAVSIYMAAIYLHA FLVFTAAFRTKTGTFLIRLSSAVLMITIAFSMIYSFGVFRQEVTLTINQMIWIHGFVN AFGVILPALIGWRIEDAKPFDADSVKTFSRIYGKRKIGEEFLANIQAENNARYSGLVD DMGSLRSKDFSPEKLAPLILSFYEQTIEYNIKAKVTWSTWFRPLAIIYEWFSRRIGQI HLSTNPDWYRMYSKIKGVHSKKDGRERVRAWIRTNEKNETIFTALYSVYRSNGEGYMN ISLPLPFSSMTGILKPYHHQEKLVLTSRRRKSRAGDEGIYLQTRAGTCPLPLSETFLI EAVHDNKLTAVHHMWLFGIKFLTVHYSITHINQPIERT*" /label="yndJ CDS" gene 1642476..1644116 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /label="yndJ gene" promotor_-10 complement(1642750..1642769) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1642763) /Source="Nicolas_upshifts" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1642783..1642791) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1643756..1644522) /Source="Nicolas_S_feature" /locus_tag="new_1914233_1914999_c" /HighExp="T2.0H, T1.30H, T2.30H, GM 150, T3.30H, T1.0H, C30, T3.0H, T4.0H, T0.30H" /AntisenseName="yndK" /AntisenseCor="-0.33555507319526101" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S652" CDS 1644153..1644518 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage/plasmid replication protein" /protein_id="NP_389664.1" /db_xref="EnsemblGenomes-Gn:BSU17810" /db_xref="EnsemblGenomes-Tr:CAB13665" /db_xref="GOA:O31814" /db_xref="SubtiList:BG13447" /db_xref="UniProtKB/Swiss-Prot:O31814" /translation="MNCFKILHRIKTGKEGFMVFYISLFLILWLAAGFAVGMKQVYVD QLFDKAVIERLEKEANDHGHADRMIKQRVLYIAAVTVSGFISVYYEMKTIPQRRNIRK IEKNIMKLNQAKKRRMKRK*" /label="yndK CDS" gene 1644153..1644518 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /label="yndK gene" downshifts 1644495 /Source="Nicolas_upshifts" /id="D970" /incds=0 /nref=166 /ntot=243 /MaxReadThrough="2.62352" /MaxDrop="5.68917" /score="15.340233" /energy="-10.4" /TU="NA" /idTUdmin="U1426" /TUdmin=2226 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1644515..1644795) /gene="surA" /locus_tag="BSU_misc_RNA_72" /product="small untranslated RNA controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surA RNA" gene complement(1644515..1644795) /gene="surA" /locus_tag="BSU_misc_RNA_72" /label="surA gene" S_feature complement(1644524..1644655) /Source="Nicolas_S_feature" /locus_tag="new_1915001_1915132_c" /HighExp="B60, T2.0H, T1.30H, T1.0H, T2.30H, M9-stat, LoTm, S5, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.443, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S653" downshifts complement(1644567) /Source="Nicolas_upshifts" /id="D971" /incds=0 /nref=21 /ntot=129 /MaxReadThrough="4.91485" /MaxDrop="4.94426" /score="14.7738511" /energy="-10.4" /TU="U1429,U1431" /idTUdmin="U1429" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1644615..1644624 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1644637..1644646) /Source="Nicolas_upshift_promotors" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1644638..1644657 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1644643 /Source="Nicolas_upshifts" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" S_feature 1644645..1644743 /Source="Nicolas_S_feature" /locus_tag="new_1915122_1915220" /HighExp="S8, S6, S7, BT, S5, G/S, B36, C30, Pyr, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52117199999999997" /TUshortSig="SigK" /TUshortPSig="0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S654" upshifts complement(1644655) /Source="Nicolas_upshifts" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1644657..1644787) /Source="Nicolas_S_feature" /locus_tag="new_1915134_1915264_c" /HighExp="T2.0H, T1.30H, M9-stat, T2.30H, T1.0H, B60, LoTm, T4.0H, T3.30H, T0.30H" /AntisenseName="yndL" /AntisenseCor="0.22331158442510801" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S655" CDS 1644744..1645502 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /EC_number="3.4.19.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26158264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage gamma-polyglutamate hydrolase" /protein_id="NP_389665.1" /db_xref="EnsemblGenomes-Gn:BSU17820" /db_xref="EnsemblGenomes-Tr:CAB13666" /db_xref="GOA:O31815" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13448" /db_xref="UniProtKB/Swiss-Prot:O31815" /translation="MKPAKVSLLRRLLHSLKHVDCNIAKRFPSTIKIVKLLMIFMVFT PISSIYAEDVYQNFEELKNNEDPSDYGVVTKETGSPVLVLAIHGGGIEGGTSEVAREL SKEYSMYLFEGLKSAGNSVLHITSTHFDEPRALKMTGNHEYVISLHGYAEEDQQIEVG GTDRVRAADLVEKLQHAGFPAVLLNMDHPHAGVSPNNIANKSKTGLSIQIEMSTGFRK SLFGIFSLKSRAVTQNERFYEFTEVMFRFLKNSY*" /label="pghL CDS" gene 1644744..1645502 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /label="pghL gene" upshifts 1644777 /Source="Nicolas_upshifts" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1644793..1644812) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1644794) /Source="Nicolas_upshifts" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1644827..1644834) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1645317..1645528) /Source="Nicolas_S_feature" /locus_tag="new_1915794_1916005_c" /HighExp="S8, S5, S7, S6, S4, ferm, nit, BT, Pyr, G/S" /AntisenseName="yndL" /AntisenseCor="0.82198535504067005" /AntisenseRegPval="-66.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.515" /TUlongSig="NA" /TUlongPSig="NA" /label="S656" downshifts 1645481 /Source="Nicolas_upshifts" /id="D972" /incds=0 /nref=3 /ntot=23 /MaxReadThrough="4.17889" /MaxDrop="5.0493" /score="15.340233" /energy="-10.4" /TU="U1428,U1430" /idTUdmin="U1428" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" S_feature 1645526..1646145 /Source="Nicolas_S_feature" /locus_tag="new_1916003_1916622" /HighExp="S8, S6, S7, S5, C30, BT, G135, LBGstat, GM 150, M/G" /AntisenseName="yndM" /AntisenseCor="0.75549671487088998" /AntisenseRegPval="-50.2" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S657" CDS complement(1645529..1646068) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389666.1" /db_xref="EnsemblGenomes-Gn:BSU17830" /db_xref="EnsemblGenomes-Tr:CAB13667" /db_xref="GOA:O31816" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG13449" /db_xref="UniProtKB/Swiss-Prot:O31816" /translation="MTIMNGFELHYLSFVYAQEFSSKNNNLGGQMKHIIALASKIAFT LALLYVILDRVYHASFLSVMFIALFLGFVSYLSGDMLVLPRTNNITASLADFGLSFVI LWVFVLTQTRNDFSPFGAALLSAACLTVFEYFFHRYLLKNVLDENFRNELSARDNTLQ YQTEAADELFPETKEKHKE*" /label="yndM CDS" gene complement(1645529..1646068) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /label="yndM gene" promotor_-10 complement(1646069..1646083) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1646075) /Source="Nicolas_upshifts" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1646097..1646103) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1646123..1646132 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1646145..1646160 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1646147 /Source="Nicolas_upshifts" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" CDS 1646186..1646620 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /EC_number="2.5.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11244082, 16399398, 19763274, 23256780" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244082, 16399398, 19763274, 23256780; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="magnesium-dependent bacillithiol-transferase" /protein_id="NP_389667.1" /db_xref="EnsemblGenomes-Gn:BSU17840" /db_xref="EnsemblGenomes-Tr:CAB13668" /db_xref="GOA:O31817" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR022858" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13450" /db_xref="UniProtKB/Swiss-Prot:O31817" /translation="MEIKGINHLLFSVSHLDTSIDFYQKVFGAKLLVKGRTTAYFDMN GIWLALNEEPDIPRNDIKLSYTHIAFTIEDHEFEEMSAKLKRLHVNILPGRERDERDR KSIYFTDPDGHKFEFHTGTLQDRLRYYKQEKTHMHFYDETAF*" /label="fosB CDS" gene 1646186..1646620 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /label="fosB gene" CDS 1646478..1646825 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27144405" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513960.1" /translation="MNAIENQFILPTLTATNLNFIPEPFKTGFDITNKKKRICTFMMK RPFDSTTIFHIRLNLKKGVGGDFMFGEGFYPTCSTMPYLLNCTSDWVKVKLKYTLHYI LYEESELFYQMLN*" /label="yzzP CDS" gene 1646478..1646825 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /label="yzzP gene" S_feature 1646621..1646953 /Source="Nicolas_S_feature" /locus_tag="new_1917098_1917430" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T0.0H, T-1.10H, T2.30H, Salt, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.66836499999999999" /TUshortSig="SigWXY, Sig-, SigK" /TUshortPSig="1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S658" promotor_-35 1646912..1646921 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1646933..1646948 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1646955..1647133 /Source="Nicolas_S_feature" /locus_tag="new_1917432_1917610" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T-1.10H, T0.0H, T2.30H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigWXY, Sig-, SigK" /TUshortPSig="0.99, 1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S659" upshifts 1646955 /Source="Nicolas_upshifts" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1647024..1647103 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /product="putative conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="ncrF RNA" gene 1647024..1647103 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /label="ncrF gene" downshifts 1647090 /Source="Nicolas_upshifts" /id="D973" /incds=0 /nref=16 /ntot=188 /MaxReadThrough="2.99425" /MaxDrop="4.30173" /score="-1.31226475" /energy="-14.3" /TU="U1433" /idTUdmin="U1434" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1647162..1647779) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the SOS regulon" /protein_id="NP_389668.1" /db_xref="EnsemblGenomes-Gn:BSU17850" /db_xref="EnsemblGenomes-Tr:CAB13669" /db_xref="GOA:P31080" /db_xref="InterPro:IPR006197" /db_xref="InterPro:IPR006199" /db_xref="InterPro:IPR006200" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10678" /db_xref="UniProtKB/Swiss-Prot:P31080" /translation="MTKLSKRQLDILRFIKAEVKSKGYPPSVREIGEAVGLASSSTVH GHLARLETKGLIRRDPTKPRAIEILDEEVDIPQSQVVNVPVIGKVTAGSPITAVENIE EYFPLPDRMVPPDEHVFMLEIMGDSMIDAGILDKDYVIVKQQNTANNGEIVVAMTEDD EATVKRFYKEDTHIRLQPENPTMEPIILQNVSILGKVIGVFRTVH*" /label="lexA CDS" gene complement(1647162..1647779) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /label="lexA gene" downshifts complement(1647163) /Source="Nicolas_upshifts" /id="D974" /incds=0 /nref=186 /ntot=254 /MaxReadThrough="2.74616" /MaxDrop="7.90985" /score="8.16083322" /energy="-16.3" /TU="U1435" /idTUdmin="U1435" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1647803..1647822) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1647824) /Source="Nicolas_upshifts" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1647836..1647843) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1647859..1647866 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1647878 /Source="Nicolas_upshifts" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1647880..1647899 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1647929..1648246 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12581363, 16267290, 16549676, 20400548, 20807205, 23728628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12581363, 16267290, 16549676, 20400548, 20807205, 23728628; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="NP_389669.1" /db_xref="EnsemblGenomes-Gn:BSU17860" /db_xref="EnsemblGenomes-Tr:CAB13670" /db_xref="GOA:Q45056" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR022887" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11820" /db_xref="UniProtKB/Swiss-Prot:Q45056" /translation="MIMSKESIIFVGLFTVILSAVILMLSYTSSGQELNQYVKIEVQQ GDTLWSIADQVADTKKINKNDFIEWVADKNQLQTSDIQPGDELVIPLKKKHQDAYELA TVR*" /label="dinK CDS" gene 1647929..1648246 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /label="dinK gene" promotor_-10 complement(1647946..1647964) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1647949) /Source="Nicolas_upshifts" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1647978..1647985) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1648265..1648918 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /function="16.9: Replicate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12581363, 16267290, 17020588, 19060143, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase, resolvase" /protein_id="NP_389670.1" /db_xref="EnsemblGenomes-Gn:BSU17870" /db_xref="EnsemblGenomes-Tr:CAB13671" /db_xref="GOA:Q45057" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG11821" /db_xref="UniProtKB/Swiss-Prot:Q45057" /translation="MKALIYARVSTNKEQQETSLKRQEEELTAIAAENGMEVVKVISE KASGYEMDRDGVFELLDEIKNADIDVILVQDETRLGRGNAKIALLHCIYREGVKVYTT AHRGELELSEADSMVLEIVSIVEEYQRKIHNMKIRRGMKRAVKNGFKPQKNLKNQHGN SGKEKIEVPISEIVRLRANKLTFAEIAATLRGFGYDVSKATVHRRFQEYIENEETAE* " /label="dinL CDS" gene 1648265..1648918 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /label="dinL gene" promotor_-35 1648921..1648928 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-35" promotor_-10 1648942..1648961 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-10" upshifts 1648955 /Source="Nicolas_upshifts" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="upshifts" CDS 1648982..1649215 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12581363, 16267290, 18431750,19306341, 22333191, 22933559, 23099262" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389671.1" /db_xref="EnsemblGenomes-Gn:BSU17880" /db_xref="EnsemblGenomes-Tr:CAB13672" /db_xref="GOA:O31818" /db_xref="InterPro:IPR009242" /db_xref="PDB:2HEP" /db_xref="PDB:2JVD" /db_xref="PDB:3BHP" /db_xref="SubtiList:BG13466" /db_xref="UniProtKB/Swiss-Prot:O31818" /translation="MISNAKIARINELAAKAKAGVITEEEKAEQQKLRQEYLKGFRSS MKNTLKSVKIIDPEGNDVTPEKLKREQRNNKLH*" /label="ynzC CDS" gene 1648982..1649215 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /label="ynzC gene" S_feature 1649216..1649351 /Source="Nicolas_S_feature" /locus_tag="new_1919693_1919828" /HighExp="M40t90, M40t45, dia15, C90, Etha, H2O2, T5.0H, Salt, dia5, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S660" promotor_-35 1649319..1649326 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-35" promotor_-10 1649340..1649359 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-10" upshifts 1649353 /Source="Nicolas_upshifts" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="upshifts" CDS 1649384..1651387 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /EC_number="2.2.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696621, 12682299, 12882400, 27739585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696621, 12682299, 12882400, 27739585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transketolase" /protein_id="NP_389672.1" /db_xref="EnsemblGenomes-Gn:BSU17890" /db_xref="EnsemblGenomes-Tr:CAB13673" /db_xref="GOA:P45694" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005478" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033247" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11247" /db_xref="UniProtKB/Swiss-Prot:P45694" /translation="MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTK FMNVSPANPGWFNRDRFVLSAGHGSALLYSMLHLSGFDLSIEDLKGFRQWGSKTPGHP EFGHTAGVDATTGPLGQGIAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLM EGISSEAASLAGHLQLGRLIVLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVED GNNIEELTAAIEKARQNEKKPTLIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKE AYAWTYEEDFYVPSEVYEHFAVAVKESGEKKEQEWNAQFAKYKEVYPELAEQLELAIK GELPKDWDQEVPVYEKGSSLASRASSGEVLNGLAKKIPFFVGGSADLAGSNKTTIKNA GDFTAVDYSGKNFWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAAL MGLPVTYVFTHDSIAVGEDGPTHEPVEQLASLRAMPNLSLIRPADGNETAAAWKLAVQ STDHPTALVLTRQNLPTIDQTSEEALAGVEKGAYVVSKSKNETPDALLIASGSEVGLA IEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKNEVLPADVKKRLAIEMGSSFGWGKY TGLEGDVLGIDRFGASAPGETIINEYGFSVPNVVNRVKALINK*" /label="tktA CDS" gene 1649384..1651387 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /label="tktA gene" misc_feature complement(1649588..1649607) /Source="Nicolas_upshift_promotors" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1649605) /Source="Nicolas_upshifts" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1651377 /Source="Nicolas_upshifts" /id="D975" /incds=0 /nref=230 /ntot=257 /MaxReadThrough="4.5478" /MaxDrop="6.66676" /score="16.4587041" /energy="-10.6" /TU="U1439" /idTUdmin="U1436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1651389..1652047) /Source="Nicolas_S_feature" /locus_tag="new_1921866_1922524_c" /HighExp="Lbstat, C30, Salt, BC, S7, LPhT, S8, M0t90, T-0.40H, Glucon" /AntisenseName="yneE" /AntisenseCor="4.3891878649396997E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.604, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S661" upshifts 1651487 /Source="Nicolas_upshifts" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="upshifts" misc_feature 1651488..1651507 /Source="Nicolas_upshift_promotors" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1651540..1651986 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /experiment="publication(s) with functional evidences, PMID:19682252, 25041308, 22720735, 27489185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682252, 25041308, 22720735, 27489185; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor controlling DNA replication" /protein_id="NP_389673.1" /db_xref="EnsemblGenomes-Gn:BSU17900" /db_xref="EnsemblGenomes-Tr:CAB13674" /db_xref="GOA:P45707" /db_xref="InterPro:IPR019683" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG11248" /db_xref="UniProtKB/Swiss-Prot:P45707" /translation="MERHYYTYLIKEEFANHYFGRESVMFELFQDYHWTSLEKQQYEM TEKQIQYITQPIPILHMHQRLKMNLNKTDYRQLDYIYRIALPKAKGHATFMMKEHMIE IVASGDYEAETIFFEVLRKVSPCFLAMDFNSKRYGWLNPVKERNFV*" /label="pcfA CDS" gene 1651540..1651986 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /label="pcfA gene" misc_feature 1652010..1652029 /Source="Nicolas_upshift_promotors" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1652018 /Source="Nicolas_upshifts" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1652029..1652046) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1652047) /Source="Nicolas_upshifts" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1652065..1652069) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1652072..1652290 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389674.1" /db_xref="EnsemblGenomes-Gn:BSU17910" /db_xref="EnsemblGenomes-Tr:CAB13675" /db_xref="GOA:P45708" /db_xref="InterPro:IPR005359" /db_xref="SubtiList:BG11249" /db_xref="UniProtKB/Swiss-Prot:P45708" /translation="MTLWVGILVGVVALLIGVALGFFIARKYMMSYLKKNPPINEQML RMMMMQMGMKPSQKKINQMMKAMNNQTK*" /label="yneF CDS" gene 1652072..1652290 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /label="yneF gene" downshifts 1652302 /Source="Nicolas_upshifts" /id="D976" /incds=0 /nref=243 /ntot=260 /MaxReadThrough="3.51446" /MaxDrop="7.54782" /score="0.133420982" /energy="-4.3" /TU="U1441,U1442" /idTUdmin="U1439" /TUdmin=287 /isTUend="FALSE" /label="downshifts" S_feature 1652347..1652646 /Source="Nicolas_S_feature" /locus_tag="new_1922824_1923123" /HighExp="S4, S3, S5, G180, S8, T5.0H, LoTm, G135, S6, S7" /AntisenseName="ynzD" /AntisenseCor="-0.33023056016157298" /AntisenseRegPval="-7.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S662" CDS complement(1652364..1652537) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 15187183, 17350627, 22303282, 23378509, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 15187183, 17350627, 22303282, 23378509, 27965289; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase" /protein_id="NP_389675.1" /db_xref="EnsemblGenomes-Gn:BSU17920" /db_xref="EnsemblGenomes-Tr:CAB13676" /db_xref="GOA:O31819" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13467" /db_xref="UniProtKB/Swiss-Prot:O31819" /translation="MIREHLLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQ YQKQRLRAVAGDE*" /label="spo0D CDS" gene complement(1652364..1652537) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /label="spo0D gene" downshifts complement(1652377) /Source="Nicolas_upshifts" /id="D977" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="4.0851" /MaxDrop="5.22565" /score="1.92055758" /energy="-4.3" /TU="U1444,U1446" /idTUdmin="U1444" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1652575..1652594) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1652582) /Source="Nicolas_upshifts" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1652608..1652615) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1652617..1652625 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1652637..1652656) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1652637..1652655 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1652648..1652756 /Source="Nicolas_S_feature" /locus_tag="new_1923125_1923233" /HighExp="T4.0H, T3.30H, T3.0H, S2, Lbstat, T5.0H, T2.30H, S4, T-1.40H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA, SigA" /TUshortPSig="0.999, 1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S663" upshifts 1652648 /Source="Nicolas_upshifts" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1652649) /Source="Nicolas_upshifts" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1652671..1652678) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1652757..1653464 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /function="16.10: Respire" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16771673, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16771673, 16850406, 19682263; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome c-type biogenesis protein CcdA; thiol-disulfide oxido-reductase" /protein_id="NP_389676.1" /db_xref="EnsemblGenomes-Gn:BSU17930" /db_xref="EnsemblGenomes-Tr:CAB13677" /db_xref="GOA:P45706" /db_xref="InterPro:IPR003834" /db_xref="SubtiList:BG11240" /db_xref="UniProtKB/Swiss-Prot:P45706" /translation="MGDVNYFLTFGAGFLSFISPCCLPLYPAFLSYITGVSMDDVKTE KLLLQKRSLFHTLCFLLGFSVIFIALGYGTSFIGSLFRDYHDAIRQIGALLIILFGFI TLGVFRPEAMMKERRIHFKHKPSGFLGSVLIGMAFAAGWTPCTGPILAAVITLAGTNP GSAVPYMMLYVLGFAVPFLLLSFFITKLKWIRKNQLFIMKAGGVLMIVIGVLLFFNWM SLIIILLSDLFGGFTGF*" /label="ccdA CDS" gene 1652757..1653464 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /label="ccdA gene" promotor_-35 1653484..1653491 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1653503..1653522 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1653511 /Source="Nicolas_upshifts" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1653553..1653915 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative response regulator (CheY homolog)" /protein_id="NP_389677.1" /db_xref="EnsemblGenomes-Gn:BSU17940" /db_xref="EnsemblGenomes-Tr:CAB13678" /db_xref="GOA:P45709" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11250" /db_xref="UniProtKB/Swiss-Prot:P45709" /translation="MTRVLVVDDAKFMRVKIREILEEANYIIAGEAADGEQAADLYKK LRPDLVTMDITMPVKNGIKALRDILTFDPKAKVIMCTAMRQQRIVTEAIELGAKDFIV KPFEETKVLEAVSRVMGH*" /label="yneI CDS" gene 1653553..1653915 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /label="yneI gene" promotor_-35 1653933..1653936 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1653951..1653970 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1653962 /Source="Nicolas_upshifts" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1653994..1654485 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389678.1" /db_xref="EnsemblGenomes-Gn:BSU17950" /db_xref="EnsemblGenomes-Tr:CAB13679" /db_xref="GOA:P45710" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR031306" /db_xref="SubtiList:BG11251" /db_xref="UniProtKB/Swiss-Prot:P45710" /translation="MISMMIIVSSIIAVLMAVAVMVVRIKSSDKPVSPKKIILPPIFM STGALMFLFPVFWVTGAEFLEAFTLGVIFSIFLIKTSKFEIKNNEIYMKRSKAFVFIL VGLLVIRIVMKSILSTSIDYGALSGMFWILAFGMIVPWRIAMYLSYRKLHNELQSSNI QMN*" /label="yneJ CDS" gene 1653994..1654485 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /label="yneJ gene" downshifts 1654481 /Source="Nicolas_upshifts" /id="D978" /incds=0 /nref=110 /ntot=273 /MaxReadThrough="1.09905" /MaxDrop="5.9692" /score="16.4219082" /energy="-9.7" /TU="NA" /idTUdmin="U1445" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1654516..1654944) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DynA" /protein_id="NP_389679.1" /db_xref="EnsemblGenomes-Gn:BSU17960" /db_xref="EnsemblGenomes-Tr:CAB13680" /db_xref="InterPro:IPR020203" /db_xref="SubtiList:BG11252" /db_xref="UniProtKB/Swiss-Prot:P45711" /translation="MLEGWFLWFILFWVIMMVVLLSIGGFFMFRKFLKRLPKEDGRSE LDWQDYYIENSRHLWNDENKQFLDELTAPVPELFRDAAKAKIAGKIGELALKEKVAKI DQQLMIKGYILATPKRDHTFLKRHLRDKKIDLEPYQTLLK*" /label="yneK CDS" gene complement(1654516..1654944) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /label="yneK gene" downshifts complement(1654533) /Source="Nicolas_upshifts" /id="D979" /incds=0 /nref=188 /ntot=245 /MaxReadThrough="1.60911" /MaxDrop="5.09033" /score="10.710816" /energy="-9.7" /TU="NA" /idTUdmin="U1449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1654962..1654981) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1654974) /Source="Nicolas_upshifts" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1654976..1655061) /Source="Nicolas_S_feature" /locus_tag="new_1925453_1925538_c" /HighExp="S8, S6, S7, LBGstat, C30, dia15, S0, Cold, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.958, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S664" promotor_-35 complement(1654995..1655002) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1655032..1655041 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1655051..1655160 /Source="Nicolas_S_feature" /locus_tag="new_1925528_1925637" /HighExp="S8, BT, B36, S7, G/S, Pyr, B60, S6, Glucon, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S665" upshifts 1655051 /Source="Nicolas_upshifts" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1655054..1655073 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1655056..1655075) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1655061) /Source="Nicolas_upshifts" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1655063..1655146) /Source="Nicolas_S_feature" /locus_tag="new_1925540_1925623_c" /HighExp="S8, S6, S7, C30, BT, S5, Pyr, Glucon, BC, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S666" promotor_-35 complement(1655090..1655093) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1655117 /Source="Nicolas_upshifts" /id="D980" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="3.76639" /MaxDrop="5.34013" /score="5.70696998" /energy="-12.7" /TU="U1450" /idTUdmin="U1450" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1655178..1655570) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9068633, 11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068633, 11150673; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389680.1" /db_xref="EnsemblGenomes-Gn:BSU17970" /db_xref="EnsemblGenomes-Tr:CAB13681" /db_xref="GOA:Q45058" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11822" /db_xref="UniProtKB/Swiss-Prot:Q45058" /translation="MWRNASMNHSKRNDANDFDSMDEWLRQFFEDPFAWYDETLPIDL YETSQQYIIEADLTFLQPTQVTVTLSGCEFILTVKSSGQTFEKQMMLPFYFNDKNIQV ECENQILTVAVNKETEDGSSFSLQFPLS*" /label="cotM CDS" gene complement(1655178..1655570) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /label="cotM gene" downshifts complement(1655191) /Source="Nicolas_upshifts" /id="D981" /incds=0 /nref=20 /ntot=92 /MaxReadThrough="4.44864" /MaxDrop="4.9615" /score="11.5991121" /energy="-12.7" /TU="U1454" /idTUdmin="U1456" /TUdmin=486 /isTUend="FALSE" /label="downshifts" promotor_-35 1655413..1655418 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-35" promotor_-10 1655434..1655452 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-10" upshifts 1655438 /Source="Nicolas_upshifts" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="upshifts" promotor_-35 1655548..1655552 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1655562..1655576 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1655577..1655596) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1655579 /Source="Nicolas_upshifts" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1655592) /Source="Nicolas_upshifts" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1655610..1655619) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1655651..1655797) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389681.1" /db_xref="EnsemblGenomes-Gn:BSU17980" /db_xref="EnsemblGenomes-Tr:CAB13682" /db_xref="GOA:P71032" /db_xref="InterPro:IPR012614" /db_xref="SubtiList:BG11921" /db_xref="UniProtKB/Swiss-Prot:P71032" /translation="MTNKNTSKDMHKNAPKGHNPGQPEPLSGSKKVKNRNHTRQKHNS SHDM*" /label="sspP CDS" gene complement(1655651..1655797) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /label="sspP gene" downshifts complement(1655672) /Source="Nicolas_upshifts" /id="D982" /incds=0 /nref=42 /ntot=61 /MaxReadThrough="1.80349" /MaxDrop="6.88836" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1456" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1655829..1655975) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018, 10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018, 10806362; Product type s: structure" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389682.1" /db_xref="EnsemblGenomes-Gn:BSU17990" /db_xref="EnsemblGenomes-Tr:CAB13683" /db_xref="GOA:P71031" /db_xref="InterPro:IPR012613" /db_xref="SubtiList:BG11920" /db_xref="UniProtKB/Swiss-Prot:P71031" /translation="MVKRKANHVINGMNDAKSQGKGAGYIENDQLVLTEAERQNNKKR KTNQ*" /label="sspO CDS" gene complement(1655829..1655975) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /label="sspO gene" S_feature 1655975..1656108 /Source="Nicolas_S_feature" /locus_tag="new_1926452_1926585" /HighExp="S8, S7, S3, S6, LoTm, S4, S5, BT, Pyr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S667" upshifts 1655975 /Source="Nicolas_upshifts" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1655986..1655988 /Source="Nicolas_upshift_promotors" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(1655991..1656002) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1656005) /Source="Nicolas_upshifts" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1656017..1656023) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1656098..1656105 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1656110..1656202 /Source="Nicolas_S_feature" /locus_tag="new_1926587_1926679" /HighExp="B60, M40t90, T0.0H, HiOs, T4.0H, T5.0H, T2.30H, M0t90, Sw, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S668" upshifts 1656110 /Source="Nicolas_upshifts" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1656120..1656139 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1656161) /Source="Nicolas_upshifts" /id="D983" /incds=0 /nref=1 /ntot=67 /MaxReadThrough="2.77282" /MaxDrop="4.02811" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1458" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1656203..1658932 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /EC_number="4.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate hydratase (bifunctional aconitase)" /protein_id="NP_389683.1" /db_xref="EnsemblGenomes-Gn:BSU18000" /db_xref="EnsemblGenomes-Tr:CAB13684" /db_xref="GOA:P09339" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR006249" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG10478" /db_xref="UniProtKB/Swiss-Prot:P09339" /translation="MANEQKTAAKDVFQARKTFTTNGKTYHYYSLKALEDSGIGKVSK LPYSIKVLLESVLRQVDGFVIKKEHVENLAKWGTAELKDIDVPFKPSRVILQDFTGVP AVVDLASLRKAMAAVGGDPDKINPEIPVDLVIDHSVQVDKAGTEDALAVNMDLEFERN AERYKFLSWAKKAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGT DSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLAL KVTQVLREKGVVGKFVEFFGPGIAELPLADRATIANMAPEYGATCGFFPVDEEALNYL RLTGRDPEHIDVVEAYCRSNGLFYTPDAEDPQFTDVVEIDLSQIEANLSGPKRPQDLI PLSAMQETFKKQLVSPAGNQGFGLNAEEENKEIKFKLLNGEETVMKTGAIAIAAITSC TNTSNPYVLIGAGLVAKKAVELGLKVPNYVKTSLAPGSKVVTGYLVNSGLLPYMKELG FNLVGYGCTTCIGNSGPLSPEIEEAVAKNDLLITSVLSGNRNFEGRIHPLVKGNYLAS PPLVVAYALAGTVNINLKTDPIGVGKDGQNVYFNDIWPSMDEINALVKQTVTPELFRK EYETVFDDNKRWNEIETTDEALYKWDNDSTYIQNPPFFEEMSVEPGKVEPLKGLRVVG KFGDSVTTDHISPAGAIGKDTPAGKYLQEKGVSPRDFNSYGSRRGNHEVMMRGTFANI RIKNQIAPGTEGGFTTYWPTGEVTSIYDACMKYKEDKTGLVVLAGKDYGMGSSRDWAA KGTNLLGIRTVIAESFERIHRSNLVFMGVLPLQFKQGENADTLGLTGKEVIEVDVDET VRPRDLVTVRAINEDGNVTTFEAVVRFDSEVEIDYYRHGGILQMVLREKMKQS*" /label="citB CDS" gene 1656203..1658932 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /label="citB gene" misc_feature complement(1656223..1656227) /Source="Nicolas_upshift_promotors" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1656227) /Source="Nicolas_upshifts" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1658933..1659003 /Source="Nicolas_S_feature" /locus_tag="new_1929410_1929480" /HighExp="M9-stat, B60, M40t90, Glucon, M0t90, MG-0.2, Mal, T2.30H, MG-0.1, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S669" CDS 1659004..1659516 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15342593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane-bound proteins with a thioredoxin-like domain" /protein_id="NP_389684.1" /db_xref="EnsemblGenomes-Gn:BSU18010" /db_xref="EnsemblGenomes-Tr:CAB13685" /db_xref="GOA:O31820" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13451" /db_xref="UniProtKB/Swiss-Prot:O31820" /translation="MLKKWLAGILLIMLVGYTGWNLYQTYSKKEVGIQEGQQAPDFSL KTLSGEKSSLQDAKGKKVLLNFWATWCKPCRQEMPAMEKLQKEYADKLAVVAVNFTSA EKSEKQVRAFADTYDLTFPILIDKKGINADYNVMSYPTTYILDEKGVIQDIHVGTMTK KEMEQKLDLD*" /label="yneN CDS" gene 1659004..1659516 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /label="yneN gene" downshifts 1659473 /Source="Nicolas_upshifts" /id="D984" /incds=0 /nref=115 /ntot=218 /MaxReadThrough="3.76369" /MaxDrop="5.09954" /score="13.5401842" /energy="-6.9" /TU="U1457" /idTUdmin="U1457" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-35 1659542..1659548 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1659561 /Source="Nicolas_upshifts" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1659563..1659574 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1659597..1659722 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097732.1" /db_xref="EnsemblGenomes-Gn:BSU18019" /db_xref="EnsemblGenomes-Tr:CAX52626" /db_xref="InterPro:IPR025004" /db_xref="UniProtKB/Swiss-Prot:C0H418" /translation="MKKMRKRSFHELVMENKKELMTNTEYLNQLEEKLEQRFKQK*" /label="ynzL CDS" gene 1659597..1659722 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /label="ynzL gene" downshifts complement(1659615) /Source="Nicolas_upshifts" /id="D985" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.12259" /MaxDrop="3.48183" /score="-0.0160782027" /energy="-13.9" /TU="NA" /idTUdmin="U1462" /TUdmin=1298 /isTUend="FALSE" /label="downshifts" promotor_-35 1659736..1659742 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1659757..1659768 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1659759 /Source="Nicolas_upshifts" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" CDS 1659787..1659933 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054579.2" /db_xref="EnsemblGenomes-Gn:BSU18020" /db_xref="EnsemblGenomes-Tr:CAE01455" /db_xref="GOA:Q7WY69" /db_xref="InterPro:IPR012612" /db_xref="SubtiList:BG14179" /db_xref="UniProtKB/Swiss-Prot:Q7WY69" /translation="MGNNKKNGQPQYAPSHLGTKPVKYKANKGEKMHDTSGQRPIIMQ TKGE*" /label="sspN CDS" gene 1659787..1659933 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /label="sspN gene" CDS 1659970..1660221 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (thioredoxin-like protein)" /protein_id="NP_389685.1" /db_xref="EnsemblGenomes-Gn:BSU18030" /db_xref="EnsemblGenomes-Tr:CAB13686" /db_xref="GOA:Q45060" /db_xref="InterPro:IPR017524" /db_xref="SubtiList:BG11806" /db_xref="UniProtKB/Swiss-Prot:Q45060" /translation="MTKNQNQYQQPNPDDRSDNVEKLQDMVQNTIENIEEAEASMEFA SGEDKQRIKEKNARREQSIEAFRNEIQDESAARQNGYRS*" /label="sspT CDS" gene 1659970..1660221 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /label="sspT gene" downshifts 1660199 /Source="Nicolas_upshifts" /id="D986" /incds=0 /nref=41 /ntot=49 /MaxReadThrough="2.07653" /MaxDrop="7.06685" /score="32.1193211" /energy="-7" /TU="NA" /idTUdmin="U1457" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1660242..1660247 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1660261..1660280 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1660265..1660356 /Source="Nicolas_S_feature" /locus_tag="new_1930742_1930833" /HighExp="Etha, dia5, dia15, Diami, H2O2, G180, Salt, G150, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S670" upshifts 1660265 /Source="Nicolas_upshifts" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1660357..1660722 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /EC_number="3.1.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11959124, 11994151, 16294310, 18338382; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA thioesterase" /protein_id="YP_054580.1" /db_xref="EnsemblGenomes-Gn:BSU18040" /db_xref="EnsemblGenomes-Tr:CAB13687" /db_xref="GOA:Q45061" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR006684" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11823" /db_xref="UniProtKB/Swiss-Prot:Q45061" /translation="MGIVYHANYLVWMEVGRTALIKDLGFLYSDMEKKGVLSPVVDIN ISYKKPLHYGETAVVHTWIEDYNGFKTVYGYHIYNPAGELSIKATSSHICVDKESFKP IQFRKAFPDWHTAYEKAKK*" /label="yneP CDS" gene 1660357..1660722 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /label="yneP gene" CDS 1660738..1661037 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389687.1" /db_xref="EnsemblGenomes-Gn:BSU18050" /db_xref="EnsemblGenomes-Tr:CAB13688" /db_xref="SubtiList:BG11824" /db_xref="UniProtKB/Swiss-Prot:Q45062" /translation="MAFGVKREELNRWKQAVKRGEIAFLTHYWLDDRFPEAKTVTKAG CADIDKLVQWGAAYGLKKEWIHKKSEFPHFDLLGETQKYILEQENLTDHLIRFHL*" /label="yneQ CDS" gene 1660738..1661037 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /label="yneQ gene" downshifts 1661013 /Source="Nicolas_upshifts" /id="D987" /incds=0 /nref=55 /ntot=217 /MaxReadThrough="3.04989" /MaxDrop="5.5978" /score="-4.41102273" /energy="-6" /TU="NA" /idTUdmin="U1461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1661068..1661355) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 23176286" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389688.1" /db_xref="EnsemblGenomes-Gn:BSU18060" /db_xref="EnsemblGenomes-Tr:CAB13689" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR008326" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11825" /db_xref="UniProtKB/Swiss-Prot:Q45063" /translation="MNMTINEDALNWYKEELDLESGDQVRFFVRYGGCSNVQKGFSLG VAKDAPQEAGVTAEADGITFFIEESDLWYFDNHDLLVSYSEDADEPVFEYQ*" /label="yneR CDS" gene complement(1661068..1661355) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /label="yneR gene" downshifts complement(1661089) /Source="Nicolas_upshifts" /id="D988" /incds=0 /nref=216 /ntot=260 /MaxReadThrough="3.77766" /MaxDrop="7.20006" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(1661155) /Source="Nicolas_upshifts" /id="D989" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.5674" /MaxDrop="3.11178" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1661385..1661404) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1661397) /Source="Nicolas_upshifts" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1661420..1661427) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1661443..1662024) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphate:glycerol-3-phosphate O-acyltransferase" /protein_id="NP_389689.1" /db_xref="EnsemblGenomes-Gn:BSU18070" /db_xref="EnsemblGenomes-Tr:CAB13690" /db_xref="GOA:Q45064" /db_xref="InterPro:IPR003811" /db_xref="SubtiList:BG11826" /db_xref="UniProtKB/Swiss-Prot:Q45064" /translation="MLIALLIILAYLIGSIPSGLIVGKLAKGIDIREHGSGNLGATNA FRTLGVKAGSVVIAGDILKGTLATALPFLMHVDIHPLLAGVFAVLGHVFPIFAKFKGG KAVATSGGVLLFYAPLLFITMVAVFFIFLYLTKFVSLSSMLTGIYTVIYSFFVHDTYL LIVVTLLTIFVIYRHRANIKRIINKTEPKVKWL*" /label="plsY CDS" gene complement(1661443..1662024) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /label="plsY gene" S_feature 1662025..1662155 /Source="Nicolas_S_feature" /locus_tag="new_1932502_1932632" /HighExp="C30, S8, S7, S5, S6, S4, BC, S3, T4.0H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S671" misc_feature complement(1662050..1662069) /Source="Nicolas_upshift_promotors" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1662067) /Source="Nicolas_upshifts" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1662140..1662143 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1662157 /Source="Nicolas_upshifts" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1662159..1662178 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1662194..1662601 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA-binding protein" /protein_id="NP_389690.1" /db_xref="EnsemblGenomes-Gn:BSU18080" /db_xref="EnsemblGenomes-Tr:CAB13691" /db_xref="GOA:Q45065" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11827" /db_xref="UniProtKB/Swiss-Prot:Q45065" /translation="MQNPSKAEIKEILQRSKRIAVVGLSDRPDRTSHMVSKAMQDAGY EIIPVNPTIDEALGVKAVSSLKEIDGPIDIVNVFRRSEQLPGVAEEFLETDAPVFWAQ QGLVNEEAYQMLKEKGRTVIMDLCIKVAHAVTK*" /label="yneT CDS" gene 1662194..1662601 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /label="yneT gene" downshifts 1662597 /Source="Nicolas_upshifts" /id="D990" /incds=0 /nref=63 /ntot=221 /MaxReadThrough="4.35976" /MaxDrop="5.49229" /score="-2.11194139" /energy="-6" /TU="U1464" /idTUdmin="U1461" /TUdmin=1584 /isTUend="FALSE" /label="downshifts" promotor_-35 1662663..1662666 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1662681..1662700 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1662685..1662999 /Source="Nicolas_S_feature" /locus_tag="new_1933162_1933476" /HighExp="H2O2, G150, G180, Etha, Oxctl, LBGexp, dia0, Lbexp, M40t45, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S672" upshifts 1662685 /Source="Nicolas_upshifts" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" CDS 1663000..1664967 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8969507, 9539793, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8969507, 9539793, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit B of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389691.2" /db_xref="EnsemblGenomes-Gn:BSU18090" /db_xref="EnsemblGenomes-Tr:CAB13692" /db_xref="GOA:Q59192" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005740" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11804" /db_xref="UniProtKB/Swiss-Prot:Q59192" /translation="MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVY EIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHA GGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKI GKTKKTGTLTHFKPDPTMFSTTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVF YYENGIEAFVAYLNEEKDVLSEVVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRT KDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGLSAIISVRIPEELLQ FEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRDTATLLVKKAIKASQAREAARKAR EEARSGKKRKKSEATLSGKLTPAGSRNPAKNELYLVEGDSAGGSAKQGRDRRFQAVLP LRGKVINTEKAKLADIFKNEEINTIIHAIGGGVGADFSIDDINYDKIIIMTDADTDGA HIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEMGDVLKK VGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEP RRKWIEKNVAFGLDEESNILENENLSVAEEV*" /label="parE CDS" gene 1663000..1664967 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /label="parE gene" CDS 1664971..1667391 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9539793, 12682299, 16267290, 16272394, 24440393" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9539793, 12682299, 16267290, 16272394, 24440393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit A of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389692.2" /db_xref="EnsemblGenomes-Gn:BSU18100" /db_xref="EnsemblGenomes-Tr:CAB13693" /db_xref="GOA:Q45066" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005741" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="SubtiList:BG11803" /db_xref="UniProtKB/Swiss-Prot:Q45066" /translation="MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQ RRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLI EMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPA MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPT GGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMD EFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKNTDLQITYNFNMVA IHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVI ATIRSSSDKRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIE ELESILSNDKKLLKVITNSLKALKKKYADTRRSVIEEKIEEIKINLEVMVASEDVYVT VTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSYIYCPVH QLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHY KAQRYSKALVALNLKGEDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAG VKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLSEFEKTSRAKRGVVMLRELK KNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTA VWRLHTEQ*" /label="parC CDS" gene 1664971..1667391 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /label="parC gene" downshifts 1667371 /Source="Nicolas_upshifts" /id="D991" /incds=0 /nref=227 /ntot=255 /MaxReadThrough="0.556700000000001" /MaxDrop="5.87714" /score="9.15080033" /energy="-14.6" /TU="NA" /idTUdmin="U1465" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1667399..1667588) /Source="Nicolas_S_feature" /locus_tag="new_1937876_1938065_c" /HighExp="LPhT, B60, Etha, B36, Gly, LoTm, Sw, BC, S8, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99806099999999998" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="0.968, 0.994, 0.642" /TUlongSig="NA" /TUlongPSig="NA" /label="S673" CDS complement(1667438..1667614) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (C-terminus)" /db_xref="PSEUDO:SOX90559.1" /translation="MFNITRLCNENMRRLLNMLFILRMVILGLFSFTALNLFVWQGIE VIHAVTDLFTNHES*" /label="ynfCc CDS" gene complement(1667438..1667614) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /pseudo /label="ynfCc gene" downshifts complement(1667442) /Source="Nicolas_upshifts" /id="D992" /incds=0 /nref=153 /ntot=267 /MaxReadThrough="0.609599999999999" /MaxDrop="7.72532" /score="38.0779167" /energy="-14.6" /TU="NA" /idTUdmin="U1467" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1667589..1667999) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU18110" /db_xref="EnsemblGenomes-Tr:CAB13694" /db_xref="GOA:Q45067" /db_xref="PSEUDO:CAB13694.1" /db_xref="SubtiList:BG11828" /db_xref="UniProtKB/Swiss-Prot:Q45067" /translation="MDWGIIIKIFSNIKGGGDHLKKVTILKASILFLAIASFHLFSIP HAFDIGHHYKAVADQQEMHEMKAGQNADDEKKSITGAFTLTALWAMAVLLLTAESKST GYSRRRQRKKSFILAKFYQSSYFGKLHVQHHPIM*" /label="ynfCn CDS" gene complement(1667589..1667999) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /pseudo /label="ynfCn gene" promotor_-10 complement(1667972..1667991) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1667975) /Source="Nicolas_upshifts" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1668006..1668013) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1668040..1668059) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1668041) /Source="Nicolas_upshifts" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1668074..1668081) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1668088..1668107) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1668099) /Source="Nicolas_upshifts" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1668121..1668130) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1668347..1668352 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1668365..1668384 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1668370 /Source="Nicolas_upshifts" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="upshifts" S_feature 1668383..1668447 /Source="Nicolas_S_feature" /locus_tag="new_1938860_1938924" /HighExp="Cold, G180, Oxctl, G135, LBGexp, G150, HPh, dia0, Lbexp, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S674" CDS 1668448..1669845 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8969507, 12823818, 15849754, 16850406, 22607086; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+/Na+:nitrogen-donor aminoacid symporter" /protein_id="NP_389694.1" /db_xref="EnsemblGenomes-Gn:BSU18120" /db_xref="EnsemblGenomes-Tr:CAB13695" /db_xref="GOA:Q45068" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG11798" /db_xref="UniProtKB/Swiss-Prot:Q45068" /translation="MESFFNSLINIPSDFIWKYLFYILIGLGLFFTIRFGFIQFRYFI EMFRIVGEKPEGNKGVSSMQAFFISAASRVGTGNLTGVALAIATGGPGAVFWMWVVAA VGMASSFVESTLAQLYKVRDGEDFRGGPAYYIQKGLGARWLGIVFAILITVSFGLIFN AVQTNTIAGALDGAFHVNKIVVAIVLAVLTAFIIFGGLKRVVAVSQLIVPVMAGIYIL IALFVVITNITAFPGVIATIVKNALGFEQVVGGGIGGIIVIGAQRGLFSNEAGMGSAP NAAATAHVSHPAKQGFIQTLGVFFDTFIICTSTAFIILLYSVTPKGDGIQVTQAALNH HIGGWAPTFIAVAMFLFAFSSVVGNYYYGETNIEFIKTSKTWLNIYRIAVIAMVVYGS LSGFQIVWDMADLFMGIMALINLIVIALLSNVAYKVYKDYAKQRKQGLDPVFKAKNIP GLKNAETWEDEKQEA*" /label="alsT CDS" gene 1668448..1669845 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /label="alsT gene" downshifts 1669834 /Source="Nicolas_upshifts" /id="D993" /incds=0 /nref=112 /ntot=203 /MaxReadThrough="3.44078" /MaxDrop="5.75319" /score="16.664707" /energy="-14.7" /TU="U1469" /idTUdmin="U1469" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 1669879 /Source="Nicolas_upshifts" /id="D994" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.22962" /MaxDrop="5.03444" /score="16.664707" /energy="-14.7" /TU="NA" /idTUdmin="U1469" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(1669935..1670681) /Source="Nicolas_S_feature" /locus_tag="new_1940412_1941158_c" /HighExp="S6, S8, S7, S5, BT, C30, B36, S4, LoTm, B60" /AntisenseName="eglS" /AntisenseCor="0.42607634596628102" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S675" promotor_-35 1670058..1670065 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1670077 /Source="Nicolas_upshifts" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1670078..1670097 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1670148..1671647 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /EC_number="3.2.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3024130, 7704256, 7710279, 15139916, 26907762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3024130, 7704256, 7710279, 15139916, 26907762; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-1,4-beta-glucanase" /protein_id="NP_389695.2" /db_xref="EnsemblGenomes-Gn:BSU18130" /db_xref="EnsemblGenomes-Tr:CAB13696" /db_xref="GOA:P10475" /db_xref="InterPro:IPR001547" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR008965" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018087" /db_xref="InterPro:IPR036966" /db_xref="PDB:2L8A" /db_xref="PDB:3PZT" /db_xref="PDB:3PZU" /db_xref="PDB:3PZV" /db_xref="SubtiList:BG10437" /db_xref="UniProtKB/Swiss-Prot:P10475" /translation="MKRSISIFITCLLITLLTMGGMIASPASAAGTKTPVAKNGQLSI KGTQLVNRDGKAVQLKGISSHGLQWYGEYVNKDSLKWLRDDWGITVFRAAMYTADGGY IDNPSVKNKVKEAVEAAKELGIYVIIDWHILNDGNPNQNKEKAKEFFKEMSSLYGNTP NVIYEIANEPNGDVNWKRDIKPYAEEVISVIRKNDPDNIIIVGTGTWSQDVNDAADDQ LKDANVMYALHFYAGTHGQFLRDKANYALSKGAPIFVTEWGTSDASGNGGVFLDQSRE WLKYLDSKTISWVNWNLSDKQESSSALKPGASKTGGWRLSDLSASGTFVRENILGTKD STKDIPETPSKDKPTQENGISVQYRAGDGSMNSNQIRPQLQIKNNGNTTVDLKDVTAR YWYKAKNKGQNFDCDYAQIGCGNVTHKFVTLHKPKQGADTYLELGFKNGTLAPGASTG NIQLRLHNDDWSNYAQSGDYSFFKSNTFKTTKKITLYDQGKLIWGTEPN*" /label="eglS CDS" gene 1670148..1671647 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /label="eglS gene" promotor_-10 complement(1670680..1670699) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1670703) /Source="Nicolas_upshifts" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1670713..1670722) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1671595 /Source="Nicolas_upshifts" /id="D995" /incds=0 /nref=1 /ntot=89 /MaxReadThrough="3.59763" /MaxDrop="3.67571" /score="6.04626297" /energy="-10.7" /TU="NA" /idTUdmin="U1470" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1671715..1671978 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389696.1" /db_xref="EnsemblGenomes-Gn:BSU18140" /db_xref="EnsemblGenomes-Tr:CAB13697" /db_xref="InterPro:IPR020302" /db_xref="SubtiList:BG11829" /db_xref="UniProtKB/Swiss-Prot:Q45069" /translation="MDEILKQYMVLYKKMSNMINGPDYPGKEKDIQHQKDQIEVYEKQ LQQGFSTDYDYDVFADSVIKCAYGDMTLEDLEAVYYGLTTPFF*" /label="ynfE CDS" gene 1671715..1671978 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /label="ynfE gene" downshifts complement(1672237) /Source="Nicolas_upshifts" /id="D996" /incds=0 /nref=4 /ntot=148 /MaxReadThrough="1.78569" /MaxDrop="4.04338" /score="32.2414244" /energy="-12.6" /TU="NA" /idTUdmin="U1472" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1672237..1673505) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /EC_number="3.2.1.136" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17028274, 25355936, 26559526, 28330222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17028274, 25355936, 26559526, 28330222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-xylanase" /protein_id="NP_389697.1" /db_xref="EnsemblGenomes-Gn:BSU18150" /db_xref="EnsemblGenomes-Tr:CAB13698" /db_xref="GOA:Q45070" /db_xref="InterPro:IPR001139" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR033452" /db_xref="PDB:3GTN" /db_xref="PDB:3KL0" /db_xref="PDB:3KL3" /db_xref="PDB:3KL5" /db_xref="SubtiList:BG11830" /db_xref="UniProtKB/Swiss-Prot:Q45070" /translation="MIPRIKKTICVLLVCFTMLSVMLGPGATEVLAASDVTVNVSAEK QVIRGFGGMNHPAWAGDLTAAQRETAFGNGQNQLGFSILRIHVDENRNNWYKEVETAK SAVKHGAIVFASPWNPPSDMVETFNRNGDTSAKRLKYNKYAAYAQHLNDFVTFMKNNG VNLYAISVQNEPDYAHEWTWWTPQEILRFMRENAGSINARVIAPESFQYLKNLSDPIL NDPQALANMDILGTHLYGTQVSQFPYPLFKQKGAGKDLWMTEVYYPNSDTNSADRWPE ALDVSQHIHNAMVEGDFQAYVWWYIRRSYGPMKEDGTISKRGYNMAHFSKFVRPGYVR IDATKNPNANVYVSAYKGDNKVVIVAINKSNTGVNQNFVLQNGSASNVSRWITSSSSN LQPGTNLTVSGNHFWAHLPAQSVTTFVVNR*" /label="xynC CDS" gene complement(1672237..1673505) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /label="xynC gene" S_feature complement(1673506..1673635) /Source="Nicolas_S_feature" /locus_tag="new_1943983_1944112_c" /HighExp="Lbstat, BC, M0t90, LBGstat, Sw, T2.0H, M40t90, BI, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99419599999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S676" CDS complement(1673636..1675177) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1938968, 17426966, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938968, 17426966, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinoxylan arabinofuranohydrolase" /protein_id="NP_389698.1" /db_xref="EnsemblGenomes-Gn:BSU18160" /db_xref="EnsemblGenomes-Tr:CAB13699" /db_xref="GOA:Q45071" /db_xref="InterPro:IPR005084" /db_xref="InterPro:IPR006584" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR023296" /db_xref="PDB:3C7E" /db_xref="PDB:3C7F" /db_xref="PDB:3C7G" /db_xref="PDB:3C7H" /db_xref="PDB:3C7O" /db_xref="SubtiList:BG11807" /db_xref="UniProtKB/Swiss-Prot:Q45071" /translation="MRKKCSVCLWILVLLLSCLSGKSAYAATSTTIAKHIGNSNPLID HHLGADPVALTYNGRVYIYMSSDDYEYNSNGTIKDNSFANLNRVFVISSADMVNWTDH GAIPVAGANGANGGRGIAKWAGASWAPSIAVKKINGKDKFFLYFANSGGGIGVLTADS PIGPWTDPIGKPLVTPSTPGMSGVVWLFDPAVFVDDDGTGYLYAGGGVPGVSNPTQGQ WANPKTARVIKLGPDMTSVVGSASTIDAPFMFEDSGLHKYNGTYYYSYCINFGGTHPA DKPPGEIGYMTSSSPMGPFTYRGHFLKNPGAFFGGGGNNHHAVFNFKNEWYVVYHAQT VSSALFGAGKGYRSPHINKLVHNADGSIQEVAANYAGVTQISNLNPYNRVEAETFAWN GRILTEKSTAPGGPVNNQHVTSIQNGDWIAVGNADFGAGGARSFKANVASTLGGKIEV RLDSADGKLVGTLNVPSTGGAQTWREIETAVSGATGVHKVFFVFTGTGTGNLFNFDYW QFTQR*" /label="xynD CDS" gene complement(1673636..1675177) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /label="xynD gene" S_feature complement(1675178..1675499) /Source="Nicolas_S_feature" /locus_tag="new_1945655_1945976_c" /HighExp="M0t90, LBGstat, T1.30H, T2.30H, BC, M9-stat, T2.0H, T3.0H, T0.30H, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25588499999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S677" promotor_-10 complement(1675489..1675508) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1675500) /Source="Nicolas_upshifts" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1675523..1675526) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1675726..1675733 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1675746..1675765 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1675753 /Source="Nicolas_upshifts" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1675772..1676218 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein possibly involved in arabinogalactan metabolism" /protein_id="NP_389699.1" /db_xref="EnsemblGenomes-Gn:BSU18170" /db_xref="EnsemblGenomes-Tr:CAB13700" /db_xref="GOA:O31821" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG13452" /db_xref="UniProtKB/Swiss-Prot:O31821" /translation="MTATRIFYEGRFVTLKEKIKTLGRFCTVGVGNTLIDFGVFFLLT ACHVSYLPAQICSYTAGIVNSYVWNRNWTFCVKRKADGKEIVRFLMINIAASGITFLL LYLFQNCGCSLLVSKLAATIGGMMMNFIGNRIWVFGDSLKNIQDQE*" /label="yngA CDS" gene 1675772..1676218 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /label="yngA gene" CDS 1676225..1677118 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /EC_number="2.7.7.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8320212, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_389700.1" /db_xref="EnsemblGenomes-Gn:BSU18180" /db_xref="EnsemblGenomes-Tr:CAB13701" /db_xref="GOA:O31822" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13453" /db_xref="UniProtKB/Swiss-Prot:O31822" /translation="MRKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVE EAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHY IRQKEPLGLGHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGV QSVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVL KTIGRGAGNEIQLTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEM RSQLLAYLEDVIKRETKEMLR*" /label="yngB CDS" gene 1676225..1677118 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /label="yngB gene" misc_feature 1676735..1676754 /Source="Nicolas_upshift_promotors" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1676743 /Source="Nicolas_upshifts" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="upshifts" CDS 1677191..1677787 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein, phosphatase or phosphate isomerase" /protein_id="NP_389701.1" /db_xref="EnsemblGenomes-Gn:BSU18190" /db_xref="EnsemblGenomes-Tr:CAB13702" /db_xref="GOA:O31823" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13454" /db_xref="UniProtKB/Swiss-Prot:O31823" /translation="MGSLISEILTWLTNMGYAGIAIGLMIEIIPSEIVLAYGGYMVSE GTIGFIGAIIAGVIGGTIAQIFIYWIGRYGGRPFLDKYGKYLLIKKHHIDMSENWFQK YGAGVVFSARFIPVVRHAISIPAGIARMPFLKFVVLTVLAIIPWSILFVYLGIQLGSQ WDDVENIAGTYTTPIMILAVVVIALYFVIKKRTAIFKR*" /label="yngC CDS" gene 1677191..1677787 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /label="yngC gene" downshifts 1677777 /Source="Nicolas_upshifts" /id="D997" /incds=0 /nref=191 /ntot=259 /MaxReadThrough="1.94273" /MaxDrop="5.58345" /score="15.4353025" /energy="-15" /TU="NA" /idTUdmin="U1474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1677836..1679035) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19553197, 22262096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19553197, 22262096; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoribonuclease (nanoRNase)" /protein_id="NP_389702.1" /db_xref="EnsemblGenomes-Gn:BSU18200" /db_xref="EnsemblGenomes-Tr:CAB13703" /db_xref="GOA:O31824" /db_xref="SubtiList:BG13455" /db_xref="UniProtKB/Swiss-Prot:O31824" /translation="MYHLYSHNDLDGVGCGIVAKLAFGKDVEIRYNSVNGLNAQVQYF LEKAKESNRQDALFITDLAVNEENEERLNEYVHAGGKVKLIDHHKTALHLNEHEWGFV QVEYDDGRLTSATSLLYGYLIENGFMKPTNALDQFTELVRQYDTWEWERYDQKQAKRL NDLFFLLSIDEFEAKMIQRLSTHDEFFFDDFEEKLLDLEDEKIERYLRRKKREMVQTF VHEHCVGIVHAESYHSELGNRLGKDNPHLDYIAILSMGSKRVSLRTIHDYIDVSEIAG RYGGGGHAKASGCSITDEVYELFVAEAFRIDPVRPDAFRNIYNLKGSANGSLYENRAQ MRFFLFPLDNEWNIQINGETQDETFAAFEEAEWFIKRNYAASLVRDEVFVAFLAENLK LANQHRK*" /label="nrnB CDS" gene complement(1677836..1679035) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /label="nrnB gene" S_feature complement(1679036..1679107) /Source="Nicolas_S_feature" /locus_tag="new_1949513_1949584_c" /HighExp="S5, S7, S4, S8, S6, ferm, nit, LBGstat, T5.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S678" promotor_-10 complement(1679095..1679106) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1679107) /Source="Nicolas_upshifts" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1679121..1679127) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1679205..1680740) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /EC_number="6.4.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylcrotonoyl-CoA carboxylase subunit (leucinedegradation)" /protein_id="NP_389703.2" /db_xref="EnsemblGenomes-Gn:BSU18210" /db_xref="EnsemblGenomes-Tr:CAB13704" /db_xref="GOA:O31825" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13456" /db_xref="UniProtKB/Swiss-Prot:O31825" /translation="MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLF DDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTVCVMANDSTVKAGSWGAKTVEKI IRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLL FGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSIS GCGDILAETEEEAIQLVRAYLSYFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAP FDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVANQPKVKGGVLFHDSA DKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSV IVRKAYGAGLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAA FISSKREEYKEDINIYRLASEMIIDAVIPANSLRDELAKRLKAYMTKEMTFTNRKHPV YPV*" /label="ldeE CDS" gene complement(1679205..1680740) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /label="ldeE gene" downshifts complement(1679217) /Source="Nicolas_upshifts" /id="D998" /incds=0 /nref=18 /ntot=38 /MaxReadThrough="1.74923" /MaxDrop="5.31437" /score="-1.4478995" /energy="-11.8" /TU="NA" /idTUdmin="U1477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1680751..1681533) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /EC_number="4.2.1.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglutaconyl-CoA hydratase (leucine degradation)" /protein_id="NP_389704.1" /db_xref="EnsemblGenomes-Gn:BSU18220" /db_xref="EnsemblGenomes-Tr:CAB13705" /db_xref="GOA:O34893" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG13457" /db_xref="UniProtKB/Swiss-Prot:O34893" /translation="MGDSILFTVKNEHMALITLNRPQAANALSAEMLRNLQMIIQEIE FNSNIRCVILTGTGEKAFCAGADLKERIKLKEDQVLESVSLIQRTAALLDALPQPVIA AINGSALGGGLELALACDLRIATEAAVLGLPETGLAIIPGAGGTQRLPRLIGRGKAKE FIYTGRRVTAHEAKEIGLVEHVTAPCDLMPKAEELAAAISANGPIAVRQAKFAINKGL ETDLATGLAIEQKAYEQTIPTKDRREGLQAFQEKRRAVYKGI*" /label="ldeF CDS" gene complement(1680751..1681533) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /label="ldeF gene" CDS complement(1681554..1682453) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /EC_number="4.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16330546, 19935659, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxymethylglutaryl-CoA lyase (leucine degradation)" /protein_id="NP_389705.1" /db_xref="EnsemblGenomes-Gn:BSU18230" /db_xref="EnsemblGenomes-Tr:CAB13706" /db_xref="GOA:O34873" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR013785" /db_xref="PDB:1YDO" /db_xref="SubtiList:BG13458" /db_xref="UniProtKB/Swiss-Prot:O34873" /translation="MPYPKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSY IEITSFVHPKWIPALRDAIDVAKGIDREKGVTYAALVPNQRGLENALEGGINEACVFM SASETHNRKNINKSTSESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVI RLSEALFEFGISELSLGDTIGAANPAQVETVLEALLARFPANQIALHFHDTRGTALAN MVTALQMGITVFDGSAGGLGGCPYAPGSSGNAATEDIVYMLEQMDIKTNVKLEKLLSA AKWIEEKMGKPLPSRNLQVFKSS*" /label="ldeG CDS" gene complement(1681554..1682453) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /label="ldeG gene" CDS complement(1682468..1682689) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type c: carrier" /codon_start=1 /transl_table=11 /product="methylcrotonyl-CoA carboxylase; biotinylated subunit (leucine degradation)" /protein_id="YP_003097733.1" /db_xref="EnsemblGenomes-Gn:BSU18239" /db_xref="EnsemblGenomes-Tr:CAX52627" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR011053" /db_xref="PDB:1Z6H" /db_xref="PDB:1Z7T" /db_xref="PDB:2B8F" /db_xref="PDB:2B8G" /db_xref="UniProtKB/Swiss-Prot:C0H419" /translation="MTVSIQMAGNLWKVHVKAGDQIEKGQEVAILESMKMEIPIVADR SGIVKEVKKKEGDFVNEGDVLLELSNSTQ*" /label="lgeHB CDS" gene complement(1682468..1682689) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /label="lgeHB gene" CDS complement(1682704..1684038) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /EC_number="6.4.1.4" /EC_number="6.3.4.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7915138, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin carboxylase for subunit LdeHB of methylcrotonyl-CoA carboxylase" /protein_id="NP_389706.1" /db_xref="EnsemblGenomes-Gn:BSU18240" /db_xref="EnsemblGenomes-Tr:CAB13707" /db_xref="GOA:O34544" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG13459" /db_xref="UniProtKB/Swiss-Prot:O34544" /translation="MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKA ATEAYLIGESRVSESYLNIERIIKTAKKAKADAIHPGYGLLSENSRFAERCKQENIVF IGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKAS AGGGGIGMQRVENEEALKKAYEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQH GHTVHLFERDCSVQRRHQKVIEEAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEF IVDQKQNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLRIAAGHTLTFSQKDIQRNGHA IEVRIYAEDPKTFFPSPGTITAFSLPDQKGVRHECAVAKDSTVTPFYDPMIAKMIVKG QTRTEAIEKLETALRDYRVEGIKTNLPLLIQAAATKAFKEGDVTTDFLKQHL*" /label="ldeHA CDS" gene complement(1682704..1684038) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /label="ldeHA gene" CDS complement(1684048..1685697) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /EC_number="6.2.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12535077, 15213221, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl-CoA synthetase" /protein_id="NP_389707.1" /db_xref="EnsemblGenomes-Gn:BSU18250" /db_xref="EnsemblGenomes-Tr:CAB13708" /db_xref="GOA:O31826" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13460" /db_xref="UniProtKB/Swiss-Prot:O31826" /translation="MAELIHSTIGRLLEQTADAYPDRDAVVYPDRNIRYTYAQFDSLC RQTAKGLMRMGIGKGDHVAIWASNISEWLAVQFATAKIGAVLVTVNTNYQAHELDYLL KQSDAAALIIMDSYRGTSYPDIVNSLIPELQEAKPGQLKSERYPFLKTLIYIGNKRLS GMYHWDDTEILAKTVTDAELEERMNSLDKDNVINMQYTSGTTGFPKGVMLTHFNVINN AANIAECMALTSQDRMCIPVPFFHCFGCVLGVLACVSVGAAMIPVQEFDPVTVLKTVE KEKCTVLHGVPTMFIAELHHPDFDAYDLSTLRTGIMAGSPCPSEVMKAVIERMGMKDI TIAYGQTEASPVITQTRANDSFIRRVETTGRALPHTEVKIVEPGTCQEVQRGMQGELC TRGYHVMKGYYKDKDATRKAINHDGWLFTGDLAVMDEDGYCRITGRLKDMLIRGGENI YPREIEEFLYQHPAVLDVQVVGVPDAKFGEEAAAWIKLKDGKSVSPDELKAYCKGKIA RHKIPRYVIFTDDYPMTASGKIQKYKLREKTIEMFNLSSSQ*" /label="ldeI CDS" gene complement(1684048..1685697) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /label="ldeI gene" promotor_no_box 1684097..1684197 /Source="Nicolas_upshift_promotors" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1684157 /Source="Nicolas_upshifts" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1685741..1686883) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /EC_number="1.3.8.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8655474, 17085570, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isovaleryl-CoA dehydrogenase (leucine degradation)" /protein_id="NP_389708.1" /db_xref="EnsemblGenomes-Gn:BSU18260" /db_xref="EnsemblGenomes-Tr:CAB13709" /db_xref="GOA:O34421" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG13461" /db_xref="UniProtKB/Swiss-Prot:O34421" /translation="MNFELTKEQQMVREMVKDFAKKEIAPHAEHVDQTGEFPMQTFKK MGELGLMGIPFPEEYGGSGGDTISYALAVEEVGKACGSTGLSYAAAVSLGASPLYYFG TEEQKQTHLTPLASGTALGSFGLTEPNAGSDAGGTQTKAISNGDEYVINGEKCWITNA SYARTVIVTAVTGKNKDGKNIISALIVPTDTPGLTITSPYDKMGVRGSNTAEILLEDV RVPAANLLGDPTKGFKQFLYTLDGGRISIAALAVGIAQAALDASLAYAKERKQFGQPI SSFQAIQFKLADMAMEIDLARQMVLKAAWLKDHNRPFTKEAAYAKLFASEMATRACNQ AIQIHGGSGYMKEYGVERMLRDAKLMEIGEGTSEIQRLVIARQLLK*" /label="ldeJ CDS" gene complement(1685741..1686883) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /label="ldeJ gene" promotor_-10 complement(1686902..1686920) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1686919) /Source="Nicolas_upshifts" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1686936..1686941) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1686974..1687279) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389709.1" /db_xref="EnsemblGenomes-Gn:BSU18270" /db_xref="EnsemblGenomes-Tr:CAB13710" /db_xref="GOA:O34356" /db_xref="InterPro:IPR020509" /db_xref="SubtiList:BG13468" /db_xref="UniProtKB/Swiss-Prot:O34356" /translation="MLTDPAEEAFLPNFLLLGAGTALVLCLVFFLYQKLDQSQFAVIK LGIWGSAVGLLMDTISLWNLPLIFPALSKGQVIAFTIWMVCAYCMYLLIPLILSHKK* " /label="ynzE CDS" gene complement(1686974..1687279) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /label="ynzE gene" CDS complement(1687269..1687442) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513961.1" /translation="MNMEAVFGHLPLLESEKLVLNKNKIEEKHVQDVFYVFISSLVRC HIIFCAVRRCCVD*" /label="conserved protein of unknown function CDS" gene complement(1687269..1687442) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /label="gene" CDS complement(1687550..1689082) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative exported glycoside hydrolase" /protein_id="NP_389710.1" /db_xref="EnsemblGenomes-Gn:BSU18280" /db_xref="EnsemblGenomes-Tr:CAB13711" /db_xref="InterPro:IPR003790" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG13462" /db_xref="UniProtKB/Swiss-Prot:O35015" /translation="MKVCQKSIVRFLVSLIIGTFVISVPFMANAQSDRELRAVWIASV LNIDWPSKKGLSVKEQKQEYIKLLDDVQKMGMNAVIVQIKPTADAFYPSAYGPWSEYL TGVQGKDPGYDPLAFMIEETHKRNLEFHAWFNPYRITMNHTDLNKLSEDHPARKHPDW VAAYGNQLYYHPGIPEARDFIVKGIEEVVKHYDIDAVHMDDYFYPYKIAGQEFPDQAQ YEQYGKDAFSNIDDWRRDNVNQLVKQINQTIKAAKPYVKFGISPFGVWRNAADDPTGS NTKAGVRNYDDLYADTRHWIQEGDIDYIAPQIYWSIGFNAAAYDVLADWWSNEVKNRP VHLYIGQAAYKINNNFDPPWSDPEEYVRQITLNRQLELVKGSMHFSLKDLNKNPLGIK DSLSTDLYSKPALVPQMPWLDNTAPKKPKLTKVTEDKNGNLLQIKDHPSNQKTKETAY YAIYRAEGKKQRTLLATQRKTHEQQTFLDNTADPNKKYTYYVTSADRLHNESKASKRT TK*" /label="yngK CDS" gene complement(1687550..1689082) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /label="yngK gene" downshifts complement(1687561) /Source="Nicolas_upshifts" /id="D999" /incds=0 /nref=7 /ntot=27 /MaxReadThrough="2.27934" /MaxDrop="4.41371" /score="9.43133612" /energy="-8" /TU="NA" /idTUdmin="U1478" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1689117..1689136) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1689117) /Source="Nicolas_upshifts" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1689149..1689158) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1689218..1689610) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28163698; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389711.1" /db_xref="EnsemblGenomes-Gn:BSU18290" /db_xref="EnsemblGenomes-Tr:CAB13712" /db_xref="GOA:O34506" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13463" /db_xref="UniProtKB/Swiss-Prot:O34506" /translation="MDRLSFLTFIMLILASYRLTHLIVFDKITEFIRKPFMKKKRIVD QNGHVDEKSVPASNFGYMLNCYWCAGVWCAILIGLGYLFLPRIAIPLIFILAIAGAQA ILETAVGVGVKLIDVLKSLQTMMNDKKS*" /label="yngL CDS" gene complement(1689218..1689610) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /label="yngL gene" downshifts complement(1689249) /Source="Nicolas_upshifts" /id="D1000" /incds=0 /nref=2 /ntot=18 /MaxReadThrough="0.581539999999999" /MaxDrop="2.96298" /score="5.25915686" /energy="-11.4" /TU="NA" /idTUdmin="U1479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1689638..1689649) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1689645) /Source="Nicolas_upshifts" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1689663..1689669) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1689717,1689724) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs10" N_region 1689718..1689723 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs10" S_feature complement(<1689724..1689829) /Source="Nicolas_S_feature" /locus_tag="new_1997958_1998066_c" /HighExp="T1.30H, T1.0H, T0.30H, S1, M0t90, T2.30H, LPhT, C90, LoTm, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S679" promotor_-10 complement(1689814..1689833) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1689829) /Source="Nicolas_upshifts" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1689847..1689854) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1690103..1691578) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /EC_number="3.4.16.4" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733705, 9864321, 11160090, 14731276, 17582436, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 9864321, 11160090, 14731276, 17582436, 19758330; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase" /protein_id="NP_389717.1" /db_xref="EnsemblGenomes-Gn:BSU18350" /db_xref="EnsemblGenomes-Tr:CAB13718" /db_xref="GOA:P39844" /db_xref="InterPro:IPR000667" /db_xref="InterPro:IPR012338" /db_xref="PDB:1W5D" /db_xref="PDB:2J9P" /db_xref="SubtiList:BG10969" /db_xref="UniProtKB/Swiss-Prot:P39844" /translation="MKKSIKLYVAVLLLFVVASVPYMHQAALAAEKQDALSGQIDKIL ADHPALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFT TEVRTDGTLKGKKLNGNLYLKGKGDPTLLPSDFDKMAEILKHSGVKVIKGNLIGDDTW HDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVIVEVTPNQKEGEEPAVSVS PKTDYITIKNDAKTTAAGSEKDLTIEREHGTNTITIEGSVPVDANKTKEWISVWEPAG YALDLFKQSLKKQGITVKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAE VLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQ LLYDIQDQSWFSAYLNSLPVAGNPDRMVGGTLRNRMKGTPAQGKVRAKTGSLSTVSSL SGYAETKSGKKLVFSILLNGLIDEEDGKDIEDQIAVILANQ*" /label="dacC CDS" gene complement(1690103..1691578) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /label="dacC gene" downshifts complement(1690115) /Source="Nicolas_upshifts" /id="D1003" /incds=0 /nref=126 /ntot=224 /MaxReadThrough="1.56173" /MaxDrop="5.81468" /score="20.5621533" /energy="-10.2" /TU="NA" /idTUdmin="U1484" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(1691612..1692589) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /EC_number="5.1.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9733705, 12753898, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 12753898, 19758330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldose 1-epimerase" /protein_id="NP_389718.1" /db_xref="EnsemblGenomes-Gn:BSU18360" /db_xref="EnsemblGenomes-Tr:CAB13719" /db_xref="GOA:P39840" /db_xref="InterPro:IPR008183" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR014718" /db_xref="PDB:3MWX" /db_xref="PDB:4BZE" /db_xref="PDB:4BZF" /db_xref="PDB:4BZG" /db_xref="PDB:4BZH" /db_xref="SubtiList:BG10253" /db_xref="UniProtKB/Swiss-Prot:P39840" /translation="MANFIEKITYLGTPAIKAGNEHLEMIVVPEWGSNVISLVDKTTN VQLLREPETAESFHDTPTLYGIPILFPPNRISDGTFSFRGRTYHFDINEKDKHNHLHG FLYHEKWNVVTTKQTDEGVIVETEIDLSELPHVQKQFPHHAVVRMTYTIKENTLFKHA TVMNKGKEAFPWGIGYHTTFIFPAESSLFSLTADQQWELDERLLPTGKLMDVPYKEAL HEGMDLRHKQLDDVFLSSYQKRGGENQAVIYHQHAHISIIYKADEQFKHWVVYNADGK QGYLCPEPYTWVTNAVNLDLPSSLTGLQVLEPGEETTAKSSITIELNHQ*" /label="galM CDS" gene complement(1691612..1692589) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /label="galM gene" promotor_-10 complement(1692618..1692636) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1692630) /Source="Nicolas_upshifts" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1692648..1692656) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1692723..1694114) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven efflux transporter" /protein_id="NP_389719.2" /db_xref="EnsemblGenomes-Gn:BSU18370" /db_xref="EnsemblGenomes-Tr:CAB13720" /db_xref="GOA:O34474" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13548" /db_xref="UniProtKB/Swiss-Prot:O34474" /translation="METSQEPLVTQKKSKPSVWRSMSLFLVPLLLSNVLQSVGQLVGM MAVGRWLGVDAVAAVSSFFPLFFLLISFTIGIGSGSSILIGQAYGAKNEERLKAVVGT TLTFTFLLGVVLAVIGSIFTLDILRLMGTPENVIHVSANYARILFYAMPFMFLYFAYT TFLRGTGDSKTPFYTLIVSTVINIALLPVLILGMFGFPKLGIYGSAYATVISTIATFL VLMVYLRKRKHPLQFDKTVRRYLKMDKELLVLLLRLGVPASINMILVSLSEIAVISFV NHYGSNATAAYGVVNQVASYVQMPAVSLGIAVSIFAAQSIGANEFDRLKQVIRVGIWL NYIIGGVLIILIYVFSHQILSLFLTEQETLYIAHRLLMITLWSYLLFGNAQIISATMR ASGTVLWPTVISIFAIWGVEVPVAFVLSHYTKLEILGVWVGYPAAFAVSLLLIYGYYQ FVWKKKQITRLIQ*" /label="yoeA CDS" gene complement(1692723..1694114) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /label="yoeA gene" downshifts complement(1692737) /Source="Nicolas_upshifts" /id="D1004" /incds=0 /nref=74 /ntot=213 /MaxReadThrough="2.12119" /MaxDrop="5.14152" /score="31.8413544" /energy="-12.3" /TU="NA" /idTUdmin="U1486" /TUdmin=2 /isTUend="TRUE" /label="downshifts" downshifts 1692883 /Source="Nicolas_upshifts" /id="D1005" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="1.76262" /MaxDrop="3.63403" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1485" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" promotor_-35 1693904..1693910 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-35" promotor_-10 1693924..1693942 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-10" S_feature 1693935..1694268 /Source="Nicolas_S_feature" /locus_tag="new_2002172_2002505" /HighExp="M9-stat, Etha, Gly, S8, Sw, S7, B60, S6, Salt, C30" /AntisenseName="yoeA" /AntisenseCor="9.0133358617756607E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S680" upshifts 1693935 /Source="Nicolas_upshifts" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="upshifts" S_feature complement(1694115..1694219) /Source="Nicolas_S_feature" /locus_tag="new_2002352_2002456_c" /HighExp="S8, LBGstat, Etha, Cold, S7, T-1.40H, S2, C90, nit, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.456" /TUlongSig="NA" /TUlongPSig="NA" /label="S681" promotor_no_box complement(1694179..1694279) /Source="Nicolas_upshift_promotors" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1694219) /Source="Nicolas_upshifts" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1694241..1694246 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1694262..1694280 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1694270 /Source="Nicolas_upshifts" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1694328..1694335 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1694348..1694367 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1694351 /Source="Nicolas_upshifts" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" CDS 1694400..1694945 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17483219, 17581128, 18761694, 22720735, 23091053" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483219, 17581128, 18761694, 22720735, 23091053; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of DL-endopeptidases involved in cell-separation" /protein_id="NP_389720.2" /db_xref="EnsemblGenomes-Gn:BSU18380" /db_xref="EnsemblGenomes-Tr:CAB13721" /db_xref="InterPro:IPR031841" /db_xref="PDB:2RSX" /db_xref="SubtiList:BG13549" /db_xref="UniProtKB/Swiss-Prot:O34841" /translation="MKKCLLFLTTIALILSLSTNAFAKNTSGDLSQKQALQLALSARE HFWNTMSGHNPKVKKAVCPSGTFEYQNLQYVYMCSDLGTKAKAVNYLTPIFTKTAIEK GFKDYHFTVSKGKLAVPIGDGDNLLNWKKSTAKLISKKGSTITYEFTVPTLDGSPSAK RKVTFVKENKKWKVNQFDAVI*" /label="iseA CDS" gene 1694400..1694945 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /label="iseA gene" downshifts 1694929 /Source="Nicolas_upshifts" /id="D1006" /incds=0 /nref=164 /ntot=264 /MaxReadThrough="4.38689" /MaxDrop="8.27665" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA complement(1695039..1695111) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg1 tRNA" gene complement(1695039..1695111) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /label="trnSL-Arg1 gene" downshifts complement(1695137) /Source="Nicolas_upshifts" /id="D1007" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="1.99821" /MaxDrop="3.03097" /score="3.94141467" /energy="-15.1" /TU="NA" /idTUdmin="U1489" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1695164..1695709) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacteriophage integrase" /protein_id="NP_389721.2" /db_xref="EnsemblGenomes-Gn:BSU18390" /db_xref="EnsemblGenomes-Tr:CAB13722" /db_xref="GOA:O35009" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG13550" /db_xref="UniProtKB/Swiss-Prot:O35009" /translation="MHIVQPIRSLEKIQEVKQYLLNKNKRDYFLFIFGINSALRISDI LPLQVKDVQNKDHLWATESKTKKKRKILILESLKQEIYEYTKDMKENEYLFKSVRTRK PISRIQAYRILREAAAACGLEEIGTHTLRKTFGYHFYQRTKDIAELQRILNHSSPSIT MRYIGIDEDTTRAAYKVFGGL*" /label="yoeC CDS" gene complement(1695164..1695709) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /label="yoeC gene" promotor_-10 complement(1695749..1695768) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1695763) /Source="Nicolas_upshifts" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1695782..1695789) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1696025..1696255) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16880568; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excisionase" /protein_id="NP_389722.1" /db_xref="EnsemblGenomes-Gn:BSU18400" /db_xref="EnsemblGenomes-Tr:CAB13723" /db_xref="GOA:O34555" /db_xref="InterPro:IPR010093" /db_xref="SubtiList:BG13551" /db_xref="UniProtKB/Swiss-Prot:O34555" /translation="MYLTIEETAEYTNLSEDYIKSLVLEGKIRAVHDGEQFLIYKEQF KTHLEQLENYKALVQEILNEPIPEDIDVKDED*" /label="yoeD CDS" gene complement(1696025..1696255) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /label="yoeD gene" downshifts complement(1696039) /Source="Nicolas_upshifts" /id="D1008" /incds=0 /nref=193 /ntot=248 /MaxReadThrough="0.81591" /MaxDrop="5.75977" /score="19.8797745" /energy="-8.6" /TU="NA" /idTUdmin="U1490" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1696281..1696300) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1696293) /Source="Nicolas_upshifts" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1696312..1696318) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1696347..1696366) /Source="Nicolas_upshift_promotors" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1696357) /Source="Nicolas_upshifts" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1696370..1696377 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1696391..1696410 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1696395 /Source="Nicolas_upshifts" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="upshifts" CDS 1696440..1698203 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /EC_number="2.3.2.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8763966, 23335395, 24279353, 26370226, 28120195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763966, 23335395, 24279353, 26370226, 28120195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound gamma-glutamyltranspeptidase" /protein_id="NP_389723.1" /db_xref="EnsemblGenomes-Gn:BSU18410" /db_xref="EnsemblGenomes-Tr:CAB13724" /db_xref="GOA:P54422" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="PDB:2V36" /db_xref="PDB:3A75" /db_xref="PDB:3WHQ" /db_xref="PDB:3WHR" /db_xref="PDB:3WHS" /db_xref="SubtiList:BG11838" /db_xref="UniProtKB/Swiss-Prot:P54422" /translation="MKRTWNVCLTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVG KDGMVATAHPLASEIGADVLKKGGNAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDG KTKDTTIIDSRERAPAGATPDMFLDENGKAIPFSERVTKGTAVGVPGTLKGLEEALDK WGTRSMKQLITPSIKLAEKGFPIDSVLAEAISDYQEKLSRTAAKDVFLPNGEPLKEGD TLIQKDLAKTFKLIRSKGTDAFYKGKFAKTLSDTVQDFGGSMTEKDLENYDITIDEPI WGDYQGYQIATTPPPSSGGIFLLQMLKILDHFNLSQYDVRSWEKYQLLAETMHLSYAD RASYAGDPEFVNVPLKGLLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQV EQPKDKVEGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIP GGANEVQPNKRPLSSMTPTILFKDDKPVLTVGSPGGATIISSVLQTILYHIEYGMELK AAVEEPRIYTNSMSSYRYEDGVPKDVLSKLNGMGHKFGTSPVDIGNVQSISIDHENGT FKGVADSSRNGAAIGINLKRK*" /label="ggt CDS" gene 1696440..1698203 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /label="ggt gene" downshifts 1698184 /Source="Nicolas_upshifts" /id="D1009" /incds=0 /nref=24 /ntot=49 /MaxReadThrough="1.41914" /MaxDrop="5.80171" /score="3.23845421" /energy="-10.4" /TU="NA" /idTUdmin="U1492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1698304..1699161) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17526699" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_389724.1" /db_xref="EnsemblGenomes-Gn:BSU18420" /db_xref="EnsemblGenomes-Tr:CAB13725" /db_xref="GOA:O34685" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13552" /db_xref="UniProtKB/Swiss-Prot:O34685" /translation="MESGDLKIFQAVAREGSITKAAQMLNYVQSNVTARVHNLEEDLN IRLFHRTNRGMKLTAAGENLLQYADQVLSLLDQAEKSTRMSRQPKGPLRIGSLETMAV THLPEHAASFLRRFPEVDLSVNTADTHHLIQQVLDHKVDGAFVYGPVEHAAVRQLHVS HDELVLISSREGTAEDMLQQPMLFFGAGCSHRDRVKRLLEEAGIHNQKIIEFGTLEAI IKGVSAGMGTALLPKSAVDGSEHRTNVWIHQLPPSYQDLEIVFIYRKDFFITSAFQTF LDEINEMKR*" /label="ftsR CDS" gene complement(1698304..1699161) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /label="ftsR gene" promotor_-10 complement(1699207..1699226) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1699227) /Source="Nicolas_upshifts" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1699240..1699247) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1699289..1700278 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 23873705; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389725.1" /db_xref="EnsemblGenomes-Gn:BSU18430" /db_xref="EnsemblGenomes-Tr:CAB13726" /db_xref="GOA:O35017" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13553" /db_xref="UniProtKB/Swiss-Prot:O35017" /translation="MKAVIHNGKAGLLGLSVQDVPSTKPGYGEVKVKLKSAGLNHRDL FLMKNKSEQDPHMILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPE ILGGPSDGTLAEYVIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEH LLIPGIGSGVATYALFMAKAIGATVSVTSRSEEKRKKALKLGADYAFDSYSNWDEQLQ GKKIDVVLDSIGPALFSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTS MGSGEEFQAMLAFIDKHKLRPVIDRIYPLEKACEAYKRMQEGRQFGNIGIVME*" /label="yogA CDS" gene 1699289..1700278 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /label="yogA gene" S_feature complement(1699345..1700303) /Source="Nicolas_S_feature" /locus_tag="new_2007582_2008540_c" /HighExp="T-4.40H, T-5.40H, Glu, GM 45, Glucon, GM-0.1, Gly, GM-0.2, UNK1, GM 90" /AntisenseName="yogA" /AntisenseCor="-0.49303153269799599" /AntisenseRegPval="-17.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S682" CDS complement(1700335..1701816) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3011766, 10651638, 11029411, 27223617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3011766, 10651638, 11029411, 27223617; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (small subunit, NADP-dependent)" /protein_id="NP_389726.2" /db_xref="EnsemblGenomes-Gn:BSU18440" /db_xref="EnsemblGenomes-Tr:CAB13727" /db_xref="GOA:O34399" /db_xref="InterPro:IPR006005" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR028261" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12594" /db_xref="UniProtKB/Swiss-Prot:O34399" /translation="MGKPTGFMEIKREKPAERDPLTRLKDWKEYSAPFSEEASKRQGA RCMDCGTPFCQIGADINGFTSGCPIYNLIPEWNDLVYRGRWKEALERLLKTNNFPEFT GRVCPAPCEGSCTLAISDPAVSIKNIERTIIDKGFENGWIQPRIPKKRTGKKVAIVGS GPAGLASADQLNQAGHSVTVFERADRAGGLLTYGIPNMKLEKGIVERRIKLLTQEGID FVTNTEIGVDITADELKEQFDAVILCTGAQKQRDLLIEGRDSKGVHYAMDYLTLATKS YLDSNFKDKQFIDAKGKDVIVIGGGDTGADCVATALRQKAKSVHQFGKHPKLPPARTN DNMWPEQPHVFTLEYAYEEAEAKFGRDPREYSIQTTKMVADKNGKLKELHTIQMEKVK NEHGKYEFRELPGTEKVWPAQLVFIAIGFEGTEQPLLKQFGVNSVNNKISAAYGDYQT NIDGVFAAGDARRGQSLIVWAINEGREVAREVDRYLMGSSVLP*" /label="gltB CDS" gene complement(1700335..1701816) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /label="gltB gene" downshifts complement(1700348) /Source="Nicolas_upshifts" /id="D1010" /incds=0 /nref=247 /ntot=279 /MaxReadThrough="3.292" /MaxDrop="7.52772" /score="10.4717228" /energy="-6.5" /TU="U1495" /idTUdmin="U1495" /TUdmin="-570" /isTUend="FALSE" /label="downshifts" CDS complement(1701833..1706395) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (large subunit, NADP-dependent)" /protein_id="NP_389727.2" /db_xref="EnsemblGenomes-Gn:BSU18450" /db_xref="EnsemblGenomes-Tr:CAB13728" /db_xref="GOA:P39812" /db_xref="InterPro:IPR002489" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR006982" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR036485" /db_xref="SubtiList:BG10811" /db_xref="UniProtKB/Swiss-Prot:P39812" /translation="MTYNQMPKAQGLYRPEFEHDACGIGLYAHLKGKQTHDIVKQGLK MLCQLDHRGGQGSDPDTGDGAGLLVQIPDAFFRKECKNINLPEKERYGVGMVFFSQKE DERKKIEKQINALIEQEGQVVLGWRTVPVNVGKIGTVAQKSCPFVRQVFIGASSDLKD NLSFERKLYVIRKQAENWGVTEGLDFYFASLSSQTIVYKGLLTPEQVDAFYSDLQDEA FVSAFALVHSRFSTNTFPTWERAHPNRYLVHNGEINTLRGNINWMRAREQQFVSESFG EDLNKILPILNADGSDSSILDNAFEFFVMAGRKPAHTAMMLIPEPWTENTHMSKEKRA FYEYHSSLMEPWDGPTAISFTDGKQIGAILDRNGLRPARYYVTKDDYIIFSSEVGVIE VEQENVLYKNRLEPGKMLLIDLEEGRIISDEEVKTQIATEYPYQKWLEEELVQVNPDP ESREEEQFSDLLTRQKAFGYTYEDIQKYLIPVIKEGKDPLGSMGNDAPLAVLSDRAQS LFNYFKQLFAQVTNPPIDAIREQLVTSTMTWLGAEGDLLHPSERNVRRIKLYTPVLSN EQFYALKTIVHPDLKSQKIDVLFSEDLERGLKDMFTQAEKAISQGVSLLILSDKKMNE RLTPIPPLLAVSALHQHLIRKGLRTKVSIIVESGEAREVHHFAALIGYGADAINPYLA YATYKQEIDEGRLDISYEEAVSKYGKSITEGVVKVMSKMGISTVQSYRGAQIFEAVGI SRDVIDRYFSGTASQLGGIDLQTIAEEAQRRHREAYQDDYSKTLEPGSDFQWRNGGEH HAFNPKTIHTLQWACRRNDYNLFKQYTKAADEERIGFLRNLFAFDGNRKPLKLEEVES AESIVKRFKTGAMSFGSLSKEAHEALAIAMNRLGGKSNSGEGGEDPKRFVPDENGDDR RSAIKQIASGRFGVKSHYLVNADELQIKMAQGAKPGEGGQLPGNKVYPWVADVRGSTP GVGLISPPPHHDIYSIEDLAQLIHDLKNANRDARISVKLVSKAGVGTIAAGVAKATAD VIVISGYDGGTGASPKTSIKHTGLPWELGLAEAHQTLMLNGLRDRVVLETDGKLMTGR DVVMAALLGAEEFGFATAPLVVLGCVMMRACHLDTCPVGVATQNPELRKKFMGDPDHI VNYMLFIAEEVREYMAALGFKTFDEMIGRTDVLHASERAKEHWKASQLDLSTLLYQPE GVRTFQSPQNHKIDQSLDITTILPAVQEAIESGKEADISIEINNTNRVAGTITGSEIS KRYGEEGLPEDTIKLHFTGSAGQSFGAFVPKGMTLYLDGDSNDYVGKGLSGGKIIVKS SEGFNSASDDNVIIGNVAFYGATSGEAYINGRAGERFAVRNSGVNVVVEGIGDHGCEY MTGGSVVVLGDVGKNFAAGMSGGIAYVLTEDVKAFKRKCNLEMILFESLEDEKEIQQI KAMLERHTAYTNSQKAEDLLDQWEDSVKKFVKVIPKNYKQMLASIEEQKAAGLSDEEA IMFAFEANTKPKQNTAASGQKQAVVQ*" /label="gltA CDS" gene complement(1701833..1706395) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /label="gltA gene" promotor_no_box 1704856..1704956 /Source="Nicolas_upshift_promotors" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1704916 /Source="Nicolas_upshifts" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1706396..1706467) /Source="Nicolas_S_feature" /locus_tag="new_2014633_2014704_c" /HighExp="SMM, T-5.40H, HiOs, MG 15, Glu, T-4.40H, MG 150, MG 60, UNK1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S683" promotor_-10 complement(1706447..1706466) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1706464..1706471 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1706467) /Source="Nicolas_upshifts" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1706481..1706488) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1706483 /Source="Nicolas_upshifts" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1706486..1706505 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1706542..1707444 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2548995, 15150225, 17134717, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2548995, 15150225, 17134717, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family) (GltC-glutamate)" /protein_id="NP_389728.2" /db_xref="EnsemblGenomes-Gn:BSU18460" /db_xref="EnsemblGenomes-Tr:CAB13729" /db_xref="GOA:P20668" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10810" /db_xref="UniProtKB/Swiss-Prot:P20668" /translation="MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELN VTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLA SQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKI LFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLV STEGEDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNR ELAPSANDFYEFVIQFFSKLEQYQ*" /label="gltC CDS" gene 1706542..1707444 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /label="gltC gene" downshifts 1707424 /Source="Nicolas_upshifts" /id="D1011" /incds=0 /nref=104 /ntot=241 /MaxReadThrough="2.84467" /MaxDrop="3.98111" /score="22.3639229" /energy="-13.6" /TU="NA" /idTUdmin="U1496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1707496..1708611) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /EC_number="2.7.2.11" /function="16.8: Protect" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:11418582, 15804359, 21784929, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 15804359, 21784929, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389729.1" /db_xref="EnsemblGenomes-Gn:BSU18470" /db_xref="EnsemblGenomes-Tr:CAB13740" /db_xref="GOA:O07509" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG12658" /db_xref="UniProtKB/Swiss-Prot:O07509" /translation="MTPDTSMKRVVVKIGSSSLTSLHGEISIRKLEALVDQVVKLKDA GYEVILVSSGAVAAGYRKLGFIQRPEKLPEKQASASIGQGLLMEAYSKLFLAHGYVAS QILITRSDFSDEYRYNNVRNTMNVLLERGIIPIINENDTVTVNRLKFGDNDTLAAKVA GLIDADMLVILSDIDGLYDGNPRTNPEAKKIQRVSEITPDIEACAGDTGSIVGTGGMR SKLDAFKIVMASGIKGFLGQADAGDILYHAVHEQAEGTYFEAEGTLPLNQKEQWIAFN SGPEGEMILSDDCSRKITNGQSSLYLDGVQKIKGKFKSGSVVRLMDSKGTEIGLGIVN YSSVQLQEPEKKKELTNRALIDQEAFVCHVDFSLPVN*" /label="proJ CDS" gene complement(1707496..1708611) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /label="proJ gene" CDS complement(1708608..1709501) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21784929, 22139509, 25344233, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21784929, 22139509, 25344233, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase" /protein_id="NP_389730.2" /db_xref="EnsemblGenomes-Gn:BSU18480" /db_xref="EnsemblGenomes-Tr:CAB13741" /db_xref="GOA:P0CI77" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11049" /db_xref="UniProtKB/Swiss-Prot:P0CI77" /translation="MRTKKRTKEMLPIFDQKKVAFIGAGSMAEGMISGIVRANKIPKQ NICVTNRSNTERLTELELQYGIKGALPNQLCIEDMDVLILAMKPKDAENALSSLKSRI QPHQLILSVLAGITTSFIEQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKK LAEALLGCMGEVYTIQENQMDIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSI GAQTLLGAAKMLMETGEHPEILRDNITSPNGTTAAGLQALKKSGGGEAISQAIKHAAK RSKEISEDIEKTAAPLSGVIK*" /label="proH CDS" gene complement(1708608..1709501) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /label="proH gene" promotor_-10 complement(1709506..1709525) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1709514 /Source="Nicolas_upshifts" /id="D1012" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="1.17009" /MaxDrop="3.27004" /score="-0.988973561" /energy="-13.3" /TU="NA" /idTUdmin="U1496" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" upshifts complement(1709524) /Source="Nicolas_upshifts" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1709539..1709545) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1709554..1709572) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1709572) /Source="Nicolas_upshifts" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1709588..1709593) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1709649..1710017) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11313334, 15657033, 16822523, 17376071, 17521668, 24946150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11313334, 15657033, 16822523, 17376071, 17521668, 24946150; Product type f : factor" /codon_start=1 /transl_table=11 /product="replication terminator protein" /protein_id="NP_389731.1" /db_xref="EnsemblGenomes-Gn:BSU18490" /db_xref="EnsemblGenomes-Tr:CAB13742" /db_xref="GOA:P0CI76" /db_xref="InterPro:IPR003432" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1BM9" /db_xref="PDB:1F4K" /db_xref="PDB:1J0R" /db_xref="PDB:2DPD" /db_xref="PDB:2DPU" /db_xref="PDB:2DQR" /db_xref="PDB:2EFW" /db_xref="SubtiList:BG10738" /db_xref="UniProtKB/Swiss-Prot:P0CI76" /translation="MKEEKRSSTGFLVKQRAFLKLYMITMTEQERLYGLKLLEVLRSE FKEIGFKPNHTEVYRSLHELLDDGILKQIKVKKEGAKLQEVVLYQFKDYEAAKLYKKQ LKVELDRCKKLIEKALSDNF*" /label="rtp CDS" gene complement(1709649..1710017) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /label="rtp gene" promotor_-10 complement(1710052..1710070) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-10" upshifts complement(1710075) /Source="Nicolas_upshifts" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="upshifts" S_feature complement(1710077..1710196) /Source="Nicolas_S_feature" /locus_tag="new_2018314_2018433_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, LBGtran, LoTm, LBGexp, G180, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S684" promotor_-35 complement(1710082..1710090) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-35" promotor_-10 complement(1710188..1710207) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1710196) /Source="Nicolas_upshifts" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1710198..1710294) /Source="Nicolas_S_feature" /locus_tag="new_2018435_2018531_c" /HighExp="Etha, dia15, LBGtran, LoTm, dia5, H2O2, LBGexp, M0t45, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S685" promotor_-35 complement(1710222..1710229) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1710317..1711033) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxido-reductase" /protein_id="NP_389732.1" /db_xref="EnsemblGenomes-Gn:BSU18500" /db_xref="EnsemblGenomes-Tr:CAB13743" /db_xref="GOA:P14802" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11048" /db_xref="UniProtKB/Swiss-Prot:P14802" /translation="MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVE KVAEEVKALGVKAAFAAADVKDADQVNQAVAQVKEQLGDIDILINNAGISKFGGFLDL SADEWENIIQVNLMGVYHVTRAVLPEMIERKAGDIINISSTAGQRGAAVTSAYSASKF AVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVA QLKLDPRIFIKTAGLWSTNP*" /label="yoxD CDS" gene complement(1710317..1711033) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /label="yoxD gene" downshifts complement(1710339) /Source="Nicolas_upshifts" /id="D1013" /incds=0 /nref=109 /ntot=217 /MaxReadThrough="4.9568" /MaxDrop="5.08605" /score="27.1231718" /energy="-7.5" /TU="U1501" /idTUdmin="U1500" /TUdmin="-594" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1711071..1711090) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1711080) /Source="Nicolas_upshifts" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1711106..1711109) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1711134..1711140 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1711154..1711172 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1711159 /Source="Nicolas_upshifts" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="upshifts" CDS 1711184..1711489 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16513748, 17598888; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="transition-dependent and sulfur-related metabolism protein" /protein_id="NP_389733.1" /db_xref="EnsemblGenomes-Gn:BSU18510" /db_xref="EnsemblGenomes-Tr:CAB13744" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG11047" /db_xref="UniProtKB/Swiss-Prot:P28670" /translation="MIIVYISLAVLAVSIIFLGVTVIQNKKKIDPALKELSSVTQAMQ KQIEGLKTETELLTQKQKKIQQDVQIKKYTLQQTAAEVKEVPQAVKEVWQAGHFNSR* " /label="yoxC CDS" gene 1711184..1711489 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /label="yoxC gene" downshifts 1711473 /Source="Nicolas_upshifts" /id="D1014" /incds=0 /nref=6 /ntot=88 /MaxReadThrough="5.31272" /MaxDrop="3.8396" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin="-1473" /isTUend="FALSE" /label="downshifts" CDS 1711560..1712330 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 17598888, 19703276" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389734.1" /db_xref="EnsemblGenomes-Gn:BSU18520" /db_xref="EnsemblGenomes-Tr:CAB13745" /db_xref="InterPro:IPR020530" /db_xref="InterPro:IPR036895" /db_xref="SubtiList:BG11046" /db_xref="UniProtKB/Swiss-Prot:P28671" /translation="MIINRSCLKEFAEKVHFLPSSLTKSDLLTDPFRLHQENELGIYY SPHNEFINRDASLVIAGITPGFSQMKTAYETAAESLLQGGTLEQMAVDTKIAAGFSGS MRHNLITMLDLCGLPQAFGIQSAAKLFGELRHMLHTTSVIKYPVFIQQKNYTGYKPAI THSPILSTYAFGHFPAELNHVTGPALLIPLGKAAETVCETLIRQHSLQNLICLNGFPH PSGANGHRLKQFSKNKEQLERQIRSFAALVDFAIEKRK*" /label="yoxB CDS" gene 1711560..1712330 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /label="yoxB gene" promotor_-35 1712312..1712319 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1712331 /Source="Nicolas_upshifts" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1712334..1712353 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1712374..1712907 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 11717291, 17598888; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389735.2" /db_xref="EnsemblGenomes-Gn:BSU18530" /db_xref="EnsemblGenomes-Tr:CAB13746" /db_xref="GOA:O34569" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13472" /db_xref="UniProtKB/Swiss-Prot:O34569" /translation="MFPILETDRLILRQITDQDAEAIFACFSNDEVTRYYGLENMESI EQAISMIQTFAALYQEKRGIRWGIERRDTKELIGTIGFHALAQKHRRAEIGYEIIPEH WRNGFASEVISKVVSYGFSALGLSRIGAVVFTDNEASNRLLLKMGFQKEGVLRQYMYQ NGTPYDTNVYSIVKPRE*" /label="yoaA CDS" gene 1712374..1712907 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /label="yoaA gene" S_feature 1712908..1712993 /Source="Nicolas_S_feature" /locus_tag="new_2021145_2021230" /HighExp="Salt, Sw, B60, LoTm, B36, M9-stat, BC, Lbstat, HiTm, Etha" /AntisenseName="yoaB" /AntisenseCor="-0.17521117067018899" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S686" downshifts 1712950 /Source="Nicolas_upshifts" /id="D1015" /incds=0 /nref=6 /ntot=100 /MaxReadThrough="4.32682" /MaxDrop="3.67936" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1712986..1714230) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12193636, 15849754, 16513748, 16850406, 28546427; Product type t : transporter" /codon_start=1 /transl_table=11 /product="negatively charged metabolite transporter" /protein_id="NP_389736.1" /db_xref="EnsemblGenomes-Gn:BSU18540" /db_xref="EnsemblGenomes-Tr:CAB13747" /db_xref="GOA:O34864" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13473" /db_xref="UniProtKB/Swiss-Prot:O34864" /translation="MLDKIGIPKRLAWGFLGVVLFMMGDGLEQGWLSPFLIENGLTVQ QSASIFSIYGIALAIASWFSGVCLEAFGAKRTMFMGLLFYVIGTAAFIVFGFEQLNLP VMYVTYFVKGLGYPLFAYSFLTWVIYRTPQSKLSTAVGWFWIAYCLGMFVFGAWYSSY AIKAFGYLNTLWSSIFWVCLGAFFALFINKDRFEKKKRKRSETAEELLKGVTILFTNP RVLTGGIIRIINSIGTYGFPVFLPMHMAQHGISTNVWLQIWGTIFLGNIVFNLIFGIV GDKFGWKNTVIWFGGVGCGIFTVLLYYAPVFSGGSLAVVSVIGFIWGGLLAGYVPIGA IVPTVAGKDKGAAMSVLNLAAGLSAFVGPALAWLFIGLVGAQGVVWIFAALYLASAVL TKCIHIPEEKAVKEETSPQYAS*" /label="yoaB CDS" gene complement(1712986..1714230) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /label="yoaB gene" S_feature 1712995..1713734 /Source="Nicolas_S_feature" /locus_tag="new_2021232_2021971" /HighExp="LoTm, Salt, Sw, S6, Etha, M9-stat, LPhT, B60, T2.0H, T2.30H" /AntisenseName="yoaB" /AntisenseCor="-0.18536963552729299" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S687" downshifts complement(1713000) /Source="Nicolas_upshifts" /id="D1016" /incds=0 /nref=32 /ntot=113 /MaxReadThrough="2.59019" /MaxDrop="4.97477" /score="29.0246554" /energy="-12.5" /TU="NA" /idTUdmin="U1504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1714231..1714323) /Source="Nicolas_S_feature" /locus_tag="new_2022468_2022560_c" /HighExp="MG 10, MG 5, BMM, MG t5, MG 15, GM 25, HiTm, UNK1, GM 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S688" CDS complement(1714324..1715787) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10094622, 12193636, 16850406, 18039762, 21749987, 27795321, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxylated metabolite kinase" /protein_id="NP_389737.1" /db_xref="EnsemblGenomes-Gn:BSU18550" /db_xref="EnsemblGenomes-Tr:CAB13748" /db_xref="GOA:O34861" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG13474" /db_xref="UniProtKB/Swiss-Prot:O34861" /translation="MKKQKGYLVFDIGTGNARVAVVSVTGSVLTVEREDIEYSTETLY PDSRYFSPQVLWKQVMNLAKRALSRSCDIDIIGLTSTSQRQGIVLIDQNGNPFLGLPN IDNRGREWEAGIPDWEEIYSSTGRLPTALFSALKLYGLKQRQPSLWEKTASFTSISDW VTYQLSGILTYEPSQATETLLFDVKQNTWSEEMCDIFGFSPSILPPLVRAGTAIGTIA NEYASELGLSINAKVIAGGGDTQLAVKSTGAGLEDIVIVSGTTTPITKITEDHGDTKH KAWLNCHTDQGHWLVETNPGITGLNYQKLKQIFYPNETYEVMEEEISALAKEDHACVA ALGSYLSAEKNALTRGGFLFDAPLSAHLKRAHFVRAALEEIAFSIKWNFDILTEVTPF ERDYVWVCGGGFQSKALTQYIADLLQKKVYVQEGYHQASVVGAAVICNETFQLTEEMS ANVRVIEPKDCQIELALYEEWKQTQRFFSGSESKVLI*" /label="yoaC CDS" gene complement(1714324..1715787) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /label="yoaC gene" CDS complement(1715805..1716839) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10094622, 11390694, 12193636, 17012385, 18039762, 21749987, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-hydroxyacid dehydrogenase" /protein_id="NP_389738.1" /db_xref="EnsemblGenomes-Gn:BSU18560" /db_xref="EnsemblGenomes-Tr:CAB13749" /db_xref="GOA:O34815" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13475" /db_xref="UniProtKB/Swiss-Prot:O34815" /translation="MKNTMKRMFCSMTVLVTAPYNEEGRKELENLFGSVAYQSWKEQG RAYREDELIQLLKATNATGLITELDQVTDSVFASVPELSFVGVCRGMPSNVDVAAASK RGIPVFYTPGRNAQAVAEMFIGNVISFLRHTSASNQWLKDGEWDSDYLQAYVKFKGNE LTGKTVGMIGFGAVGQRIAKLLTAFDCKIKYYDPYIQDDHPLYEKASLKTVFSDSDIV SVHLPRTEETLGLIDRQYFDLMKESAIFVNTSRAVVVNREDLLFVLKEHKISGAILDV FYHEPPEESDYELISLPNVLATPHLAGATFEVEDHHVTILNKALKKWKGEKTLNIQTM YNKDALKTGG*" /label="yoaD CDS" gene complement(1715805..1716839) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /label="yoaD gene" S_feature complement(1716851..1716922) /Source="Nicolas_S_feature" /locus_tag="new_2025088_2025159_c" /HighExp="MG t5, MG 5, MG 10, BMM, GM 25, MG 15, Heat, GM 15, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S689" downshifts complement(1716894) /Source="Nicolas_upshifts" /id="D1017" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="7.78218" /MaxDrop="4.81701" /score="26.3160061" /energy="-11.4" /TU="U1504" /idTUdmin="U1507" /TUdmin=2727 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1716923..1717014) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /product="AdoMet riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswF RNA" gene complement(1716923..1717014) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /label="mswF gene" promotor_-10 complement(1717042..1717061) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1717054) /Source="Nicolas_upshifts" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1717076..1717083) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1717096..1717103 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1717117..1717136 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1717121 /Source="Nicolas_upshifts" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="upshifts" CDS 1717163..1719205 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170332, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin cofactor oxido-reductase" /protein_id="NP_389739.2" /db_xref="EnsemblGenomes-Gn:BSU18570" /db_xref="EnsemblGenomes-Tr:CAB13750" /db_xref="GOA:C0SP82" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG13476" /db_xref="UniProtKB/Swiss-Prot:C0SP82" /translation="MRSFATQQNGIFKSVCSLDCPDQCGLLIHKKDGKIVKVQGDPDH PVTAGNICNKVRNMTERIYDEKRLTTPLKRTGAKGQAIFEPISWKEAIDTITSRWKQL IDEEGAESILPYSFYGNMGKLTAEGMDRRFFYRMGSSQLERTICSKAGSEGYKYTMGI SAGIDPEETVHTKLFIFWGINAVSTNMHQITIAQKARKKGAKIVVIDVHKNQTGRLAD WFIPIKPGTDSALALGIMHILFKENLHDEAFLSEYTVGYEELREHVKQYDPEKVSTIT GVSTEDIYRLAKMYGETSPSFIRIGNGPQHHDNGGMIVRTIACLPAITGQWLHTGGGA IKHNSGILEYNTNALQRPDLLKGRTPRSFNMNQLGRVLLETDPPIRSLFIYGTNPAVV APEANKVRQGLLREDLFTVVHDLFLTETAAYADIVLPATSAFENTDFYTSYWHHYIQL QQPVIERYGESKSNTEVFRLLAEAMGFTDQELKDSDEVLIRQALDHPDNPHLAEIDYD SLTKHSFMKAKREKPLFPGELPTPSGKIELYSEKMKQDGFPALPTYTPLVTDNEHPFM YVPGPNHNFLNSTFSNNEKHIKLEKTPKLFINTKDAEKHGIVDGAPVRIWNSRGECEL TAAVGEQVLPGVVVSQGLWADEQGKKQLVNALTPDRLSDMGGGATFFSGRVQIEKV*" /label="yoaE CDS" gene 1717163..1719205 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /label="yoaE gene" promotor_-35 1719213..1719222 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1719235..1719250 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1719238 /Source="Nicolas_upshifts" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1719272..1719565 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389740.1" /db_xref="EnsemblGenomes-Gn:BSU18580" /db_xref="EnsemblGenomes-Tr:CAB13751" /db_xref="SubtiList:BG13477" /db_xref="UniProtKB/Swiss-Prot:O31829" /translation="MDVFLGIGIALAGYFIGEGLKQRNQTKGNEQNDIFLIKERDIYF YIGLFLGITTTEAKQLAGDMADLPYIEINGKKYVQKHMLKDWTFTLVEKHQGE*" /label="yoaF CDS" gene 1719272..1719565 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /label="yoaF gene" downshifts 1719545 /Source="Nicolas_upshifts" /id="D1018" /incds=0 /nref=97 /ntot=243 /MaxReadThrough="3.40762" /MaxDrop="4.1662" /score="-6.27063114" /energy="-3.9" /TU="U1506" /idTUdmin="U1505" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1719590..1719937) /Source="Nicolas_S_feature" /locus_tag="new_2027827_2028174_c" /HighExp="T0.30H, S0, T1.0H, aero, Etha, S8, SMMPr, T-0.40H, ferm, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S690" downshifts complement(1719621) /Source="Nicolas_upshifts" /id="D1019" /incds=0 /nref=43 /ntot=202 /MaxReadThrough="2.3171" /MaxDrop="4.25059" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1719938..1720342) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 15849754, 16850406, 20011599, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage-related membrane protein" /protein_id="NP_389741.1" /db_xref="EnsemblGenomes-Gn:BSU18590" /db_xref="EnsemblGenomes-Tr:CAB13752" /db_xref="GOA:O31830" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG13478" /db_xref="UniProtKB/Swiss-Prot:O31830" /translation="MKKIASYYLMTLGLSSLTFGLLLGFYSFVMYGDMIIALFTAAIA LLYGFVVYGLFAVPLQMKLQKKARTFNVMYLLIYSVVAFIAAFLFFVINEPASIAWTL QSYFYYMLSIAAAVIYWLWDSLILYKRTASGV*" /label="yoaG CDS" gene complement(1719938..1720342) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /label="yoaG gene" S_feature complement(1720343..1720438) /Source="Nicolas_S_feature" /locus_tag="new_2028580_2028675_c" /HighExp="T0.30H, T1.0H, T0.0H, T-0.40H, S0, T-1.10H, T-1.40H, SMMPr, Salt, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S691" promotor_-10 complement(1720428..1720443) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1720428..1720547) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513962.1" /translation="MHFFHSRFGQSGEAFSASVLSNKRTSFLKPFISALRIAR*" /label="hypothetical protein CDS" gene complement(1720428..1720547) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /label="gene" upshifts complement(1720438) /Source="Nicolas_upshifts" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1720456..1720465) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1720543..1720549 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1720563..1720574 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1720574..1720782 /Source="Nicolas_S_feature" /locus_tag="new_2028811_2029019" /HighExp="S5, S8, S7, S6, S4, ferm, BT, nit, T5.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99998799999999999" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S692" upshifts 1720574 /Source="Nicolas_upshifts" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1720617..1720739 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513963.1" /db_xref="EnsemblGenomes-Gn:BSU18596" /db_xref="EnsemblGenomes-Tr:CCQ48597" /db_xref="UniProtKB/TrEMBL:L8E9J0" /translation="MSKKGIQNSSIEQIRNDHETETAFKADDPKKHGSDPKRTK*" /label="conserved hypothetical protein CDS" gene 1720617..1720739 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /label="gene" CDS 1720783..1721076 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="YP_054581.1" /db_xref="EnsemblGenomes-Gn:BSU18600" /db_xref="EnsemblGenomes-Tr:CAE01456" /db_xref="InterPro:IPR025100" /db_xref="SubtiList:BG14189" /db_xref="UniProtKB/Swiss-Prot:Q7WY68" /translation="MTQKNGADRPDDYKRFSSLDKEYDFQQSIRSNTETESVNTETQT HNKENKNDTTDVAGKYFEPSDYKGSTQLEKGLAETHEQVSDDYFEGTIDQNLD*" /label="yozQ CDS" gene 1720783..1721076 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /label="yozQ gene" S_feature 1721077..1721170 /Source="Nicolas_S_feature" /locus_tag="new_2029314_2029407" /HighExp="S5, S8, S6, S7, S4, BT, ferm, nit, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S693" downshifts 1721127 /Source="Nicolas_upshifts" /id="D1020" /incds=0 /nref=14 /ntot=74 /MaxReadThrough="3.32407" /MaxDrop="3.87581" /score="-6.27063114" /energy="-3.9" /TU="U1508" /idTUdmin="U1506" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1721192..1722877) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting chemotaxis protein" /protein_id="NP_389742.2" /db_xref="EnsemblGenomes-Gn:BSU18610" /db_xref="EnsemblGenomes-Tr:CAB13753" /db_xref="GOA:C0SP89" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR007891" /db_xref="SubtiList:BG13479" /db_xref="UniProtKB/Swiss-Prot:C0SP89" /translation="MKVKTKLLGIISILVVSIIGIGGSSVFMISSTVKKNEELKDKME FQKEIKHIQYELTGLSNDERGFLITRDKEYDEGMKGKADDVLKSLDRVNDLIDEEKYQ SNIEDIKTSFTQYRALNQQVVTAYSSNPKKAETIHFGEERTIRKEGVAPAVNKLSDRL DQEVEDLKDEIQGNGKMSQSLIIIVTGISVILGIVLSIMLLKSIMVPLRSINKQLEEI AHGEADLTKKVIVKNKDEFGQLAQSFNSFTHSLTQIVKQISSSSEQVAASSEELSASA EESKSTSEHISRAMQMAADSNVKQSSMTEKSAESITELLDSISSVASNTGNIADLSSS MRDKAEIGSKSVNKMLDQMKFIDKSVDSAGNGLQTLVASTAEISDISSLITTISEQTN LLALNAAIEAARAGEQGKGFAVVAEEVRKLADETNKSANHIQSVVATIQNESIETVNN IKVVQENVSSGIVLSQETTGNFNEILNLVEQVTSQIQEVAAATQQLTSGVEVIQHTVH TLAAGTKETSANTEAVANSSQEQLHSMGEISYAAESLSQLAEELQTVINRFKY*" /label="yoaH CDS" gene complement(1721192..1722877) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /label="yoaH gene" downshifts complement(1721204) /Source="Nicolas_upshifts" /id="D1021" /incds=0 /nref=68 /ntot=193 /MaxReadThrough="2.22411" /MaxDrop="4.20676" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1509" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(1722878..1722965) /Source="Nicolas_S_feature" /locus_tag="new_2031115_2031202_c" /HighExp="Cold, C30, LBGstat, GM 90, GM 15, GM 45, GM 25, GM 60, GM 10, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115923" /TUshortSig="SigD" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S694" promotor_-10 complement(1722957..1722975) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1722965) /Source="Nicolas_upshifts" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1722989..1722996) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1723134..1723143 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1723153 /Source="Nicolas_upshifts" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1723156..1723175 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1723202..1724653 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /EC_number="1.14.14.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 4-hydroxyphenylacetate-3-hydroxylase" /protein_id="NP_389743.2" /db_xref="EnsemblGenomes-Gn:BSU18620" /db_xref="EnsemblGenomes-Tr:CAB13754" /db_xref="GOA:C0SPC0" /db_xref="InterPro:IPR004925" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR012687" /db_xref="InterPro:IPR024674" /db_xref="InterPro:IPR024719" /db_xref="InterPro:IPR036250" /db_xref="SubtiList:BG13480" /db_xref="UniProtKB/Swiss-Prot:C0SPC0" /translation="MGIINGKEFIDRLNKLENEIWYDGEKIKGNISEHPAFKGIIKTK SSLYELQTKDELIHEMTYCLPGDHNRIGLSYLQPKTKNDLKKRRTMIEHWARHTHGMM GRSPDYMNTVMMSFASSAELLKDKENCFPEHILDMYEQAAKHDLSFTHTFITPQVNRS QSYFGLSEKPISAKVIDRTEKGLMIHGARLLATQGGLTDEILVFSAPKFFFETDEAYA FSIPSNTKGVKFITRESFVLSDSSFNHPLSSRYEEMDSIVVFDHVLVPWNRVFFYDNV EAAKDFMTKSSFHAFTFHQVVIRQMIKIEFLLGVAQLLVDTINVSEYQHIQEKLSEII VGLETIKALIDKSENDAQLDEFGYMRPCLIPLQVISTIIPKLYPRFTEIIQLIGASGM VTLPTENAFDSEIREDLDQYLQATNTNAEERVKIFRLAWDLTMSSFGTRQTHYERYFF GDPIRISSRLYTSYPKQEQLNMIKTFLHADTEH*" /label="yoaI CDS" gene 1723202..1724653 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /label="yoaI gene" downshifts 1724629 /Source="Nicolas_upshifts" /id="D1022" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="2.84304" /MaxDrop="2.93575" /score="2.7297367" /energy="-12" /TU="U1510" /idTUdmin="U1510" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1724690..1725388) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 18971341, 26751268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 18971341, 26751268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular endoglucanase precursor (expansin)" /protein_id="NP_389744.1" /db_xref="EnsemblGenomes-Gn:BSU18630" /db_xref="EnsemblGenomes-Tr:CAB13755" /db_xref="GOA:O34918" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036749" /db_xref="InterPro:IPR036908" /db_xref="PDB:2BH0" /db_xref="PDB:3D30" /db_xref="PDB:4FER" /db_xref="PDB:4FFT" /db_xref="PDB:4FG2" /db_xref="PDB:4FG4" /db_xref="SubtiList:BG13481" /db_xref="UniProtKB/Swiss-Prot:O34918" /translation="MKKIMSAFVGMVLLTIFCFSPQASAAYDDLHEGYATYTGSGYSG GAFLLDPIPSDMEITAINPADLNYGGVKAALAGSYLEVEGPKGKTTVYVTDLYPEGAR GALDLSPNAFRKIGNMKDGKINIKWRVVKAPITGNFTYRIKEGSSRWWAAIQVRNHKY PVMKMEYEKDGKWINMEKMDYNHFVSTNLGTGSLKVRMTDIRGKVVKDTIPKLPESGT SKAYTVPGHVQFPE*" /label="exlX CDS" gene complement(1724690..1725388) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /label="exlX gene" downshifts complement(1724705) /Source="Nicolas_upshifts" /id="D1023" /incds=0 /nref=6 /ntot=95 /MaxReadThrough="0.66874" /MaxDrop="3.60414" /score="1.1918692" /energy="-7.7" /TU="NA" /idTUdmin="U1511" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1725423..1725442) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1725442) /Source="Nicolas_upshifts" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1725444..1725657) /Source="Nicolas_S_feature" /locus_tag="new_2033681_2033894_c" /HighExp="G135, H2O2, G150, G180, LBGstat, dia15, LBGtran, Paraq, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S695" promotor_-35 complement(1725456..1725463) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1725658..1726335) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_389745.1" /db_xref="EnsemblGenomes-Gn:BSU18640" /db_xref="EnsemblGenomes-Tr:CAB13756" /db_xref="GOA:O34343" /db_xref="InterPro:IPR010699" /db_xref="SubtiList:BG13482" /db_xref="UniProtKB/Swiss-Prot:O34343" /translation="MTAAAYRNTLLSLLCLTAGIVDVIGYLSLGHVFTANMTGNIVLL GLAIGKSIQVTVFNSLTALIGFICGVIIATLMVGKAENTLWPSAVTKALALEAFILFV FACLSFYRAFVPVHILIILMSISMGIQTTAAKKLGIAGISSTVLTGTLASLLEDISGR LFFKKQKKTFLRDTVLRALAIILYCVGAIIVALAEPDFYHFIIWVPIVLIFGIMMTAK LKLSGEK*" /label="yoaK CDS" gene complement(1725658..1726335) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /label="yoaK gene" S_feature complement(1726336..1728825) /Source="Nicolas_S_feature" /locus_tag="new_2034573_2037062_c" /HighExp="LBGstat, G135, H2O2, G180, LBGtran, G150, dia15, Paraq, S0, Diami" /AntisenseName="pelB" /AntisenseCor="0.19898265589133701" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S696" CDS 1726508..1727545 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /EC_number="4.2.2.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1731776, 2018526, 2185758, 7764549, 22695924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-pectin lyase" /protein_id="NP_389746.1" /db_xref="EnsemblGenomes-Gn:BSU18650" /db_xref="EnsemblGenomes-Tr:CAB13757" /db_xref="GOA:O34819" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12643" /db_xref="UniProtKB/Swiss-Prot:O34819" /translation="MKRLCLWFTVFSLFLVLLPGKALGAVDFPNTSTNGLLGFAGNAK NEKGISKTGTTGGKNGQIVYIQSVNDLKTHLGGSTPKILVLQNDLSASAKTTVTIGSN KTLVGSYAKKTLKNIYLTTSSAFGNVIFQNLTFEHSPQINGNNDIQLYLDSGMNYWID HVTFSGHSYNASGSDLDKLVYIGKSADYITISNSKFANHKYGLILGYPDDSQHQYDGY PHMTIANNYFENLYVRGPGLMRYGYFHVKNNYSNNFNQAITIATKAKIYSEYNYFGKG SEKGGILDDKGTGYFKDIGSYPSLNKQTSPLTSWNPGSNYSYRVQTPEYTKEFVTKYA GSQSTTLVFGY*" /label="pelB CDS" gene 1726508..1727545 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /label="pelB gene" promotor_-35 1727742..1727748 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1727763..1727774 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1727775 /Source="Nicolas_upshifts" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1727802..1728485 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23945014, 26070154; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative SOS response associated protein; defective prophage 6" /protein_id="NP_389747.1" /db_xref="EnsemblGenomes-Gn:BSU18660" /db_xref="EnsemblGenomes-Tr:CAB13758" /db_xref="GOA:O34906" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13483" /db_xref="UniProtKB/Swiss-Prot:O34906" /translation="MCGRFTLYSAFDDIIDQFDIDQFFPKGEYQPSYNVAPSQNILAI INDGSNNRLGKLRWGLIPPWAKDEKIGYKMINARAETITEKPAFRRPLVSKRCIIPAD SFYEWKRLDSKTKIPMRIKLKSSALFAFAGLYEKWSTHQGYPLYTCTIITTEPNEFMK DIHDRMPVILAHDHEKEWLNPKNTSPDYLQSLLLPYDADDMEAYQVSSLVNSPKNNSA ELLDAENHM*" /label="yoaM CDS" gene 1727802..1728485 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /label="yoaM gene" CDS complement(1728826..1729131) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative permease, phage-related; defective prophage 6" /protein_id="YP_003097734.1" /db_xref="EnsemblGenomes-Gn:BSU18669" /db_xref="EnsemblGenomes-Tr:CAX52628" /db_xref="GOA:C0H420" /db_xref="UniProtKB/Swiss-Prot:C0H420" /translation="MKALIFLSSLTAIGSSILGRWLGMLDDSYAVGDAWFIGVLAGLI SLLILIDSQTMTKNYIVSLSTILGILGVGFIYFPAAFINILLSITLDKQKKEDLHVR* " /label="yozS CDS" gene complement(1728826..1729131) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /label="yozS gene" S_feature complement(1729132..1729233) /Source="Nicolas_S_feature" /locus_tag="new_2037369_2037470_c" /HighExp="HiTm, LBGstat, LBGtran, T1.30H, T1.0H, T0.30H, M9-stat, Lbstat, M0t90, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S697" promotor_-10 complement(1729212..1729231) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1729233) /Source="Nicolas_upshifts" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1729246..1729253) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1729261..1729363) /Source="Nicolas_S_feature" /locus_tag="new_2037498_2037600_c" /HighExp="S8, S6, S7, S5, BT, G/S, Pyr, B36, nit, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S698" downshifts complement(1729303) /Source="Nicolas_upshifts" /id="D1024" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="1.67639" /MaxDrop="3.95763" /score="-5.39979801" /energy="-8.3" /TU="NA" /idTUdmin="U1514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1729364..1730542) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11546787, 14697267, 14973022, 15628860, 25526893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11546787, 14697267, 14973022, 15628860, 25526893; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase (Mn2+-dependent); spore constituent" /protein_id="NP_389748.1" /db_xref="EnsemblGenomes-Gn:BSU18670" /db_xref="EnsemblGenomes-Tr:CAB13759" /db_xref="GOA:O34767" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="SubtiList:BG13484" /db_xref="UniProtKB/Swiss-Prot:O34767" /translation="MLLEQQPINHEDRNVPQPIRSDGAGAIDTGPRNIIRDIQNPNIF VPPVTDEGMIPNLRFSFSDAPMKLDHGGWSREITVRQLPISTAIAGVNMSLTAGGVRE LHWHKQAEWAYMLLGRARITAVDQDGRNFIADVGPGDLWYFPAGIPHSIQGLEHCEFL LVFDDGNFSEFSTLTISDWLAHTPKDVLSANFGVPENAFNSLPSEQVYIYQGNVPGSV ASEDIQSPYGKVPMTFKHELLNQPPIQMPGGSVRIVDSSNFPISKTIAAALVQIEPGA MRELHWHPNSDEWQYYLTGQGRMTVFIGNGTARTFDYRAGDVGYVPSNAGHYIQNTGT ETLWFLEMFKSNRYADVSLNQWMALTPKELVQSNLNAGSVMLDSLRKKKVPVVKYPGT *" /label="oxdD CDS" gene complement(1729364..1730542) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /label="oxdD gene" promotor_-10 complement(1730568..1730587) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1730587) /Source="Nicolas_upshifts" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1730601..1730610) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1730665..1731153) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389749.1" /db_xref="EnsemblGenomes-Gn:BSU18680" /db_xref="EnsemblGenomes-Tr:CAB13760" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG13485" /db_xref="UniProtKB/Swiss-Prot:O34985" /translation="MRKKNNIKKWLLIIAGFLIICIITLFVMVSGNKVKYEGSGKSGL WMSNLEKSDKTSIGPNYFLNLYWQGSKKEEKWTVVERITLYVDGEKYQDDNVDEYDLS EYTGDEMPGGGRMEDHISTFDYMPEDEVIGHDVLVKVEWRTGQKKQTEAIKLHKKPWY KK*" /label="yoaO CDS" gene complement(1730665..1731153) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /label="yoaO gene" downshifts complement(1730690) /Source="Nicolas_upshifts" /id="D1025" /incds=0 /nref=32 /ntot=201 /MaxReadThrough="0.50319" /MaxDrop="3.84714" /score="18.561323" /energy="-9.2" /TU="NA" /idTUdmin="U1514" /TUdmin="-1387" /isTUend="FALSE" /label="downshifts" CDS complement(1731178..1731333) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513964.1" /translation="MKQKMHLRAVIRFNLVFRKHFNLSQKFRQSSVRSLALSYFLFGN ILIVFSY*" /label="hypothetical protein CDS" gene complement(1731178..1731333) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /label="gene" CDS complement(1731373..1732128) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389750.1" /db_xref="EnsemblGenomes-Gn:BSU18690" /db_xref="EnsemblGenomes-Tr:CAB13761" /db_xref="GOA:O34983" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR025685" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13486" /db_xref="UniProtKB/Swiss-Prot:O34983" /translation="MCYIEITKDNIEDNHICCALSTKQYEHAVNEKKRWLKARMDEGL VFYRLHERAKVFIEYLPANEAWVPINAPNFMYINCLWVSGRYKNNGHAKRLLDKCIAD AKACGMDGIIHIAGKKKLPYLSDKHFFEHMGFTLQDEAAPYFQLMALTWNGLADSPAF KSQVKSDSINEKGITIYYTAQCPFAVGMINDLRELTEKKGVQFQSIQLSSKEEAQKSP AIWTTFSVFFDGRFVTHEIMSINKFEKLLNTLA*" /label="yoaP CDS" gene complement(1731373..1732128) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /label="yoaP gene" promotor_-35 1732381..1732386 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1732402..1732420 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1732417 /Source="Nicolas_upshifts" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="upshifts" CDS 1732436..1732792 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389751.1" /db_xref="EnsemblGenomes-Gn:BSU18700" /db_xref="EnsemblGenomes-Tr:CAB13762" /db_xref="SubtiList:BG13487" /db_xref="UniProtKB/Swiss-Prot:O31831" /translation="MVEKCYSCLICGYKGLIQNPLYKGEYQKTFDICPCCGFEFGYSE DHDVRLGFIVTPDHLIEAAFQLYRKQWLESGMVIAHPEDIPEELKNGNCLKFEVLLKQ LKKLNLDIENFEISGF*" /label="yoaQ CDS" gene 1732436..1732792 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /label="yoaQ gene" CDS complement(1732751..1732990) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (putative phage origin); putative defective prophage 6" /protein_id="YP_003097735.1" /db_xref="EnsemblGenomes-Gn:BSU18709" /db_xref="EnsemblGenomes-Tr:CAX52629" /db_xref="UniProtKB/Swiss-Prot:C0H421" /translation="MTVINDYREEPEEAFWILYPMGVKCLSMITKSLLNTNRDFVTDC AFQLNILLIMTVKPKQVQPVSSLKTANFKIFYVKI*" /label="yozT CDS" gene complement(1732751..1732990) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /label="yozT gene" S_feature 1732793..1733229 /Source="Nicolas_S_feature" /locus_tag="new_2041030_2041466" /HighExp="S8, S7, S4, S5, S6, S3, T5.0H, LoTm, BT, T4.0H" /AntisenseName="yozT" /AntisenseCor="0.93420248567111996" /AntisenseRegPval="-120.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S699" S_feature complement(1732991..1733092) /Source="Nicolas_S_feature" /locus_tag="new_2041228_2041329_c" /HighExp="S8, S7, S6, S5, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S700" CDS complement(1733093..1733590) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389752.2" /db_xref="EnsemblGenomes-Gn:BSU18710" /db_xref="EnsemblGenomes-Tr:CAB13763" /db_xref="SubtiList:BG13753" /db_xref="UniProtKB/Swiss-Prot:O31832" /translation="MKRVLFSVIVFTAVGFTFCQSKAHALTFTVLPITQKTDQWSVKV SEAKNVKEFTRPHKGEYQVYSLEVKNIGEKAATVDVQLYRNDPNSITRFSLFGCPDEN CVKPKEDSKMLAESLNDGSPLKFNHFMLADKASELEVVIIWTQKGQEGRNLKQTFKFT EDGVN*" /label="yozF CDS" gene complement(1733093..1733590) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /label="yozF gene" S_feature complement(1733591..1733690) /Source="Nicolas_S_feature" /locus_tag="new_2041828_2041927_c" /HighExp="S8, S7, S5, S6, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S701" CDS complement(1733691..1734602) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8631706; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor for cell wall maintenance or synthesis" /protein_id="NP_389753.1" /db_xref="EnsemblGenomes-Gn:BSU18720" /db_xref="EnsemblGenomes-Tr:CAB13764" /db_xref="InterPro:IPR007391" /db_xref="SubtiList:BG13488" /db_xref="UniProtKB/Swiss-Prot:O34611" /translation="MIQILITGLFLLAQPSEPQDSLTVTQQGRTIATVNREDFTMPLP GTPMVDYEKYSKFIKQLDQKVYREPINAVLNDHGSIVPGRVGYKLYQQAFMEKFYAYF YGQGPSKIEVPEMNIYPKVDSELLAHISTQQLGQYVTYFNSSNKSRSHNISLSAKAID NHVVFPNETFSFNQVVGMRTRNKGYKSAPIIVKGELSEGVGGGICQVSSTLFNAVDRA GLQIVQRYSHTRSVPYVPPGRDATVSWGGPDFRFQNQYNQPILIRAKRYGGSMIITLY SSDVINSRLRKIPKAPSRIPKEINAEQ*" /label="yoaR CDS" gene complement(1733691..1734602) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /label="yoaR gene" promotor_-10 complement(1734624..1734635) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1734626) /Source="Nicolas_upshifts" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1734650..1734656) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1734886..1734893 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1734902 /Source="Nicolas_upshifts" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1734908..1734927 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1734949..1735431 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19493340; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin / antitoxin system" /protein_id="NP_389754.1" /db_xref="EnsemblGenomes-Gn:BSU18730" /db_xref="EnsemblGenomes-Tr:CAB13765" /db_xref="GOA:O31833" /db_xref="InterPro:IPR021354" /db_xref="SubtiList:BG13489" /db_xref="UniProtKB/Swiss-Prot:O31833" /translation="MNRMSTIFLKIALVLIGIPILALCIFLVPKVANYSAELFPNIAY IKYLVFIYLYVTAIPFYFALYQAFKLLSYIDKNKAFSGLSVRALKNIKYCAVTISIFY AAGMPVFYLMAEIDDAPGIIVIGLVIIFASMVIAVFAAVLQKLLKEAIDIKSENDLTV *" /label="yoaS CDS" gene 1734949..1735431 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /label="yoaS gene" CDS 1735441..1735695 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19493340; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin of a toxin / antitoxin system; putative transcriptional regulator" /protein_id="NP_389755.1" /db_xref="EnsemblGenomes-Gn:BSU18740" /db_xref="EnsemblGenomes-Tr:CAB13766" /db_xref="GOA:O31834" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG13754" /db_xref="UniProtKB/Swiss-Prot:O31834" /translation="MAIIINIDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIR LSTLEAICKALECQPGDILEYRSDEDTGFVKKKYEGSTEK*" /label="yozG CDS" gene 1735441..1735695 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /label="yozG gene" S_feature 1735696..1735800 /Source="Nicolas_S_feature" /locus_tag="new_2043933_2044037" /HighExp="LoTm, B60, Sw, G135, G180, B36, LBGstat, Cold, LBGtran, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S702" CDS 1735801..1736595 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389756.1" /db_xref="EnsemblGenomes-Gn:BSU18750" /db_xref="EnsemblGenomes-Tr:CAB13767" /db_xref="GOA:O34535" /db_xref="InterPro:IPR008535" /db_xref="SubtiList:BG13490" /db_xref="UniProtKB/Swiss-Prot:O34535" /translation="MRAIKQIVHFGWEQALSCLFPAVIFASLAITQIIPLPFLPRYDW LLIICVLMQLWMVRSGLETRDELKVITLFHLIGLALELFKVHMGSWSYPEEGYSKIFG VPLYSGFMYASVASYLCQAWRRLKVELVKWPSFFAVVPLAAAIYLNFFTHHFSIDIRW WLSGLVIIVFWQTWVTYEVNGARYRMPLALSFILIGFFIWIAENIATFFGAWKYPNQI DTWSLVHLGKVSSWLLLVIVSFLIVASLKQVKEQSPTKAEMDESFS*" /label="yoaT CDS" gene 1735801..1736595 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /label="yoaT gene" S_feature 1736596..1737606 /Source="Nicolas_S_feature" /locus_tag="new_2044833_2045843" /HighExp="LoTm, Cold, Sw, H2O2, B60, GM 10, S8, dia15, T2.30H, MG 60" /AntisenseName="yoaU" /AntisenseCor="-2.6976304882719598E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S703" CDS complement(1736719..1737591) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_389757.1" /db_xref="EnsemblGenomes-Gn:BSU18760" /db_xref="EnsemblGenomes-Tr:CAB13768" /db_xref="GOA:O34701" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13491" /db_xref="UniProtKB/Swiss-Prot:O34701" /translation="MVMNMNHLHIFVKVGEKLNITEAAKELFISQPAVSKAIKNLESS LQLKLLIRDKHHGLMLTDIGKEILLLARQMKGIESKIYQVANRENKLLNGKVKIGSFP AVSTNIMPQAIAAFRSNYPLIRIELIEGTSDQIKGWVEDRTVDIGIAASPFEPFENQL LCNDYMVAVIPPQRDELKLEKHVDLETYQDDLIFCKGGHEIAMSNAFSQYNIELKENL TVQNAETLINMVKNNLGIGIISNFTLSSVPHQLIKKDIFPRVTRDIGVIAHSFEEITP AAHEFVKVLKAVVI*" /label="yoaU CDS" gene complement(1736719..1737591) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /label="yoaU gene" CDS 1737692..1738570 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10844694, 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative modified amino acid or TCA compound efflux permease" /protein_id="NP_389758.1" /db_xref="EnsemblGenomes-Gn:BSU18770" /db_xref="EnsemblGenomes-Tr:CAB13769" /db_xref="GOA:O34416" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG13492" /db_xref="UniProtKB/Swiss-Prot:O34416" /translation="MVKVMLGIISVTLIWGYTWVAMKVGIHDIPPLLFSGLRLFIGAV PLFLILFIQRKKLSIQKEHLKSYIIMSLLMGLGYMGILTYGMQFVDSGKTSVLVYTMP IFVTVISHFSLNEKMNVYKTMGLVCGLFGLLFIFGKEMLNIDQSALFGELCVLVAALS WGIANVFSKLQFKHIDIIHMNAWHLMMGAVMLLVFSFIFEAVPSAEWTYQAVWSLLFN GLLSTGFTFVVWFWVLNQIQASKASMALMFVPVLALFFGWLQLHEQITINIILGALLI CCGIFMNTFTFSRRKV*" /label="yoaV CDS" gene 1737692..1738570 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /label="yoaV gene" S_feature complement(1738683..1738742) /Source="Nicolas_S_feature" /locus_tag="new_2046920_2046979_c" /HighExp="BC, T4.0H, M9-stat, S5, T5.0H, S4, S3, T3.0H, T3.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.167154" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S704" downshifts complement(1738718) /Source="Nicolas_upshifts" /id="D1026" /incds=0 /nref=55 /ntot=175 /MaxReadThrough="1.78313" /MaxDrop="5.17096" /score="15.465237" /energy="-12.3" /TU="NA" /idTUdmin="U1518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1738743..1739174) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm forming exported protein" /protein_id="NP_389759.1" /db_xref="EnsemblGenomes-Gn:BSU18780" /db_xref="EnsemblGenomes-Tr:CAB13770" /db_xref="SubtiList:BG13493" /db_xref="UniProtKB/Swiss-Prot:O34541" /translation="MKKMLMLAFTFLLALTIHVGEASAVIVKDEEKVSFTMTENEKWF MKSDDLNSNHWTSHFGYRFTIFDTEGCTINARIMRMTLSGYEITVSEKNFSGDHFDFS ATDRVETMPYKTHYLILTKDPDCGDVKVKGLYGFQFDQPEW*" /label="yoaW CDS" gene complement(1738743..1739174) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /label="yoaW gene" promotor_-10 complement(1739194..1739213) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1739202) /Source="Nicolas_upshifts" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1739204..1739437) /Source="Nicolas_S_feature" /locus_tag="new_2047441_2047674_c" /HighExp="S4, S3, S5, S7, S8, S6, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S705" promotor_-35 complement(1739227..1739233) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1739438..1739456) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1739438..1740070) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16181642; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor of the oxidative stress response" /protein_id="NP_389760.1" /db_xref="EnsemblGenomes-Gn:BSU18790" /db_xref="EnsemblGenomes-Tr:CAB13771" /db_xref="GOA:O34947" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13494" /db_xref="UniProtKB/Swiss-Prot:O34947" /translation="MQTRKVYLYVFHTMSDWEYGYLIAELNSGRYFKQDAASLKVVTV GVNKEMITTLGGLSIKPDISLDECTLGSQDLIILPGGNTWGEDIHQPILKKVGDALKL GTTIAAICGATLGLANEGYLNSRKHTSNDLDYMNMVCPNYKGETFYEKGPAVSDENLV TASGIAPLEFAVEVLKKLDVFAPDTLRSWYKLNKTQKPEYFFELMNTINR*" /label="yoaZ CDS" gene complement(1739438..1740070) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /label="yoaZ gene" upshifts complement(1739444) /Source="Nicolas_upshifts" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1739472..1739477) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1740208..1740215 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1740230..1740249 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1740234 /Source="Nicolas_upshifts" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="upshifts" CDS 1740296..1741216 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /EC_number="3.5.2.6" /function="16.5: Explore" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7789815, 15187182, 16944130, 22211522, 25112476, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-lactamase precursor (putative hydrolase)" /protein_id="NP_389761.1" /db_xref="EnsemblGenomes-Gn:BSU18800" /db_xref="EnsemblGenomes-Tr:CAB13772" /db_xref="GOA:P39824" /db_xref="InterPro:IPR000871" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023650" /db_xref="SubtiList:BG11016" /db_xref="UniProtKB/Swiss-Prot:P39824" /translation="MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNM ASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYRPNERFAYASTYKVLAAAAVLKK NSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLG GPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTT DKRMILTDWMRGNATGDELIRAGAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVV AILSNRFTKDANYDNALIAEAAKVVLNDLK*" /label="penP CDS" gene 1740296..1741216 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /label="penP gene" promotor_-10 complement(1740727..1740746) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1740742) /Source="Nicolas_upshifts" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1740761..1740768) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1741217..1741874 /Source="Nicolas_S_feature" /locus_tag="new_2049454_2050111" /HighExp="HiOs, S8, GM 25, GM 15, GM-0.1, C30, S2, S1, BC, GM 45" /AntisenseName="yobA" /AntisenseCor="8.9918765131424994E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S706" CDS complement(1741713..1742075) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389762.1" /db_xref="EnsemblGenomes-Gn:BSU18810" /db_xref="EnsemblGenomes-Tr:CAB13773" /db_xref="InterPro:IPR021598" /db_xref="PDB:2JQO" /db_xref="PDB:4QY7" /db_xref="SubtiList:BG13495" /db_xref="UniProtKB/Swiss-Prot:O31835" /translation="MPKIGVSLIVLIMLIIFLAGCNKNEQNGDETKMQSLVGYVVLKD NERAILITDTKAPGKEDYNLSEGQLMNKFKNNIVIVGLSEIDNTDDLKRGEKIKVWFH TRKESNPPSATIQKYELL*" /label="yobA CDS" gene complement(1741713..1742075) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /label="yobA gene" CDS complement(1742136..1742348) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage protein" /db_xref="PSEUDO:CAX52630.1" /translation="MEVAIVNDSKDKYIYAGIQKEAAFNNIFESAKMSKRIISRATTC KYLRKNKKKVEELENEYAAVMNCKKK*" /label="yozU CDS" gene complement(1742136..1742348) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /pseudo /label="yozU gene" promotor_-35 1742387..1742394 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1742409..1742428 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1742412 /Source="Nicolas_upshifts" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="upshifts" CDS 1742452..1742715 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="NP_389763.1" /db_xref="EnsemblGenomes-Gn:BSU18820" /db_xref="EnsemblGenomes-Tr:CAB13774" /db_xref="SubtiList:BG13496" /db_xref="UniProtKB/Swiss-Prot:O31836" /translation="MKIRKILLSSALSFGMLISAVPALAAGTSSEVAVKNEEYDYDTI YRISPLPMDFQPTIEYNGYTYTLTRHYFDYSIGFYTAIYTKVV*" /label="yobB CDS" gene 1742452..1742715 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /label="yobB gene" downshifts 1742693 /Source="Nicolas_upshifts" /id="D1027" /incds=0 /nref=23 /ntot=100 /MaxReadThrough="0.60454" /MaxDrop="4.81085" /score="19.5390064" /energy="-8.7" /TU="NA" /idTUdmin="U1522" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1743092..1745692) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /EC_number="2.7.9.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PEP-dependent enzyme" /protein_id="NP_389764.1" /db_xref="EnsemblGenomes-Gn:BSU18830" /db_xref="EnsemblGenomes-Tr:CAB13775" /db_xref="GOA:O34309" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG12657" /db_xref="UniProtKB/Swiss-Prot:O34309" /translation="MSSLVLGLHEIEKTQLSLVGGKGLHLGELSKIQGIQVPEGFCVT TVGYQKAIEQNETLQVLLDQLTMLKVEDRDQIGNISRKIRQIIMEVDIPSDVVKAVAQ YLSQFGEEHAYAVRSSATAEDLPHASFAGQQDTYLNITGVDAILQHISKCWASLFTDR AVIYRMQNGFDHSQVYLSVIVQRMVFPQASGILFTADPITSNRKVLSIDAGFGLGEAL VSGLVSADCFKVQDGQIIDKRIATKKMAIYGRKEGGTETQQIDSDQQKAQTLTDEQIL QLARIGRQIEAHFGQPQDIEWCLARDTFYIVQSRPITTLFPIPEASDQENHVYISVGH QQMMTDPIKPLGLSFFLLTTVAPMRKAGGRLFVDVTHHLASPDSREVFLKGMGQHDQL LKDALMTIIKRRDFIKSIPNDKTAPNPSRGNADMPAQVENDPTIVSDLIESSQTSIEE LKQNIQTKSGSDLFRFILEDIQELKKILFNPKSSVLIRTAMNASLWINEKMNEWLGEK NAADTLSQSVPHNITSEMGLALLDVADVIRPYPEVIDYLQHVKDDNFLDELAKFDGGS KTRDAIYDYLSKYGMRCTGEIDITRTRWSEKPTTLVPMILNNIKNFEPNVGHRKFEQG RQEALKKEQELLDRLKQLPDGEQKAKETKRAIDIIRNFSGFREYPKYGMVNRYFVYKQ ALLKEAEQLIEAGVIHEKEDIYYLTFEELHEVVRTHKLDYQIISTRKDEYTLYEKLSP PRVITSDGEIVTGEYKRENLPAGAIVGLPVSSGVIEGRARVILNMEDADLEDGDILVT SFTDPSWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENAAKLIKDGQRIRV HGTEGYIEIF*" /label="yppS CDS" gene complement(1743092..1745692) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /label="yppS gene" S_feature complement(1745693..1745802) /Source="Nicolas_S_feature" /locus_tag="new_2053930_2054039_c" /HighExp="dia15, BC, S6, SMMPr, H2O2, S5, T-5.40H, S4, HPh, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S707" promotor_-35 1745718..1745725 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1745740..1745759 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1745748..1746375 /Source="Nicolas_S_feature" /locus_tag="new_2053985_2054612" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, S1, T2.30H, Heat, S2, T-5.40H, C30" /AntisenseName="xynA" /AntisenseCor="-0.30871986344497798" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S708" upshifts 1745748 /Source="Nicolas_upshifts" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1745792..1745811) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1745802) /Source="Nicolas_upshifts" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1745826..1745832) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1745848..1746307) /Source="Nicolas_S_feature" /locus_tag="new_2054085_2054544_c" /HighExp="S0, Lbstat, HiTm, dia0, ferm, Lbexp, T1.0H, M0t45, LBGtran, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S709" downshifts complement(1745890) /Source="Nicolas_upshifts" /id="D1028" /incds=0 /nref=87 /ntot=200 /MaxReadThrough="1.89557" /MaxDrop="5.26144" /score="1.97345986" /energy="-10.4" /TU="NA" /idTUdmin="U1525" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1746352) /Source="Nicolas_upshifts" /id="D1029" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="5.28207" /MaxDrop="3.16026" /score="1.97345986" /energy="-10.4" /TU="U1525" /idTUdmin="U1525" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(1746362..1747003) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /EC_number="3.2.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7704256, 8628241, 16517552, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704256, 8628241, 16517552, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-1,4-beta-xylanase" /protein_id="NP_389765.1" /db_xref="EnsemblGenomes-Gn:BSU18840" /db_xref="EnsemblGenomes-Tr:CAB13776" /db_xref="GOA:P18429" /db_xref="InterPro:IPR001137" /db_xref="InterPro:IPR013319" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018208" /db_xref="InterPro:IPR033119" /db_xref="InterPro:IPR033123" /db_xref="PDB:1AXK" /db_xref="PDB:1XXN" /db_xref="PDB:2B42" /db_xref="PDB:2B45" /db_xref="PDB:2B46" /db_xref="PDB:2DCY" /db_xref="PDB:2DCZ" /db_xref="PDB:2QZ3" /db_xref="PDB:2Z79" /db_xref="PDB:3EXU" /db_xref="PDB:3HD8" /db_xref="PDB:5K9Y" /db_xref="SubtiList:BG10808" /db_xref="UniProtKB/Swiss-Prot:P18429" /translation="MFKFKKNFLVGLSAALMSISLFSATASAASTDYWQNWTDGGGIV NAVNGSGGNYSVNWSNTGNFVVGKGWTTGSPFRTINYNAGVWAPNGNGYLTLYGWTRS PLIEYYVVDSWGTYRPTGTYKGTVKSDGGTYDIYTTTRYNAPSIDGDRTTFTQYWSVR QSKRPTGSNATITFSNHVNAWKSHGMNLGSNWAYQVMATEGYQSSGSSNVTVW*" /label="xynA CDS" gene complement(1746362..1747003) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /label="xynA gene" S_feature complement(1747004..1747121) /Source="Nicolas_S_feature" /locus_tag="new_2055241_2055358_c" /HighExp="S0, HiTm, T1.0H, Gly, Lbstat, SMMPr, Lbtran, LBGstat, SMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S710" promotor_-10 complement(1747098..1747117) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1747121) /Source="Nicolas_upshifts" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1747131..1747133) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1747209,1747216) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs05" N_region 1747210..1747215 /note="SacI site (GAGCTC)" /modified_by="User" /label="IIG_Bs05" misc_RNA <1747216..1747300 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" /product="small untranslated regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 19542274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 19542274; Product type n: RNA" /label="bsrF RNA" S_feature <1747216..1747293 /Source="Nicolas_S_feature" /locus_tag="new_2079086_2079196" /HighExp="LoTm, S7, HPh, LPhT, S8, BT, S6, G/S, S0, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.896, 1" /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S728" S_feature complement(<1747216..1747280) /Source="Nicolas_S_feature" /locus_tag="new_2078548_2079183_c" /HighExp="MG 150, S8, MG 120, S7, MG 90, GM-0.1, Glu, Fru, GM-0.2, GM 5" /AntisenseName="yobO" /AntisenseCor="0.134597835896198" /AntisenseRegPval="-1.6" /CDS_PredictionProba="0.40121099999999998" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S726" gene <1747216..1747300 /gene="bsrF" /old_locus_tag="BSU_misc_RNA_75" /locus_tag="PG10_pseudo_BSU_misc_RNA_75" /modified_by="User" /label="PG10_pseudo_BSU_misc_RNA_75" downshifts 1747278 /Source="Nicolas_upshifts" /id="D1044" /incds=0 /nref=65 /ntot=254 /MaxReadThrough="1.60135" /MaxDrop="9.06442" /score="30.7999406" /energy="-13.9" /TU="NA" /idTUdmin="U1545" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1747311..1747643) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /function="16.1: Circulate" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10658654, 10816431, 13129613, 15856219, 17372352, 28724440; Product type f : factor" /codon_start=1 /transl_table=11 /product="molecular chaperone for secreting proteins" /protein_id="NP_389785.1" /db_xref="EnsemblGenomes-Gn:BSU19040" /db_xref="EnsemblGenomes-Tr:CAB13796" /db_xref="GOA:P37584" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR008231" /db_xref="InterPro:IPR012340" /db_xref="PDB:2NZH" /db_xref="PDB:2NZO" /db_xref="SubtiList:BG10809" /db_xref="UniProtKB/Swiss-Prot:P37584" /translation="MAVIDDFEKLDIRTGTIVKAEEFPEARVPAIKLVIDFGTEIGIK QSSAQITKRYKPEGLINKQVIAVVNFPPRRIAGFKSEVLVLGGIPGQGDVVLLQPDQP VPNGTKIG*" /label="csaA CDS" gene complement(1747311..1747643) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /label="csaA gene" downshifts complement(1747325) /Source="Nicolas_upshifts" /id="D1045" /incds=0 /nref=28 /ntot=228 /MaxReadThrough="4.42209" /MaxDrop="5.706" /score="-8.98970984" /energy="-13.9" /TU="U1547" /idTUdmin="U1550" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1747708..1748433) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478, 27038276; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_389786.1" /db_xref="EnsemblGenomes-Gn:BSU19050" /db_xref="EnsemblGenomes-Tr:CAB13797" /db_xref="GOA:O34901" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG13508" /db_xref="UniProtKB/Swiss-Prot:O34901" /translation="MLMDSLQEIICEKRTYTRLYHSHKHAYSQFLFPLEGSIDLETEG RQVKLNPDHFLYIPPQCEHRFRSIGRNECLVLDVPLHAMKIDEYRAGSGIEAALDPFW SSIRYLLTEEAKAGTANSLHMLVQYIKEKLQSHSYASIAYIHSHLFERLTIKKLAEIE HYHPAYYSSWFKKQTGKSPQNYIADLRLEEAKRMLMERNETLTVVSEALGFQNLSSFT RWFTKSTGMPPRLYRNTLYSDKK*" /label="yobQ CDS" gene complement(1747708..1748433) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /label="yobQ gene" CDS complement(1748448..1749191) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389787.1" /db_xref="EnsemblGenomes-Gn:BSU19060" /db_xref="EnsemblGenomes-Tr:CAB13798" /db_xref="GOA:O34376" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13509" /db_xref="UniProtKB/Swiss-Prot:O34376" /translation="MDDIRKIERLAAASWPAYFQKSIGKWLLRANFGVTKRANSVWTS ADMPEGDFQLEAELFYQSLGLPVCFHISNASPKGLDDALADSRYEKVDECFQMTALCR SIMSRTNDNSRFTYKWEQEPSSVWIDEFIQLEGFSPERHKGYKHIFERMPPCKTFFKM YDKESLTALGTVSVIDGYGGLSNIVVAEEHRGKGAGTQVIRVLTEWAKNNGAERMFLQ VMKENLAAVSLYGKIGFSPISEHHYRIKR*" /label="yobR CDS" gene complement(1748448..1749191) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /label="yobR gene" promotor_-10 complement(1749219..1749238) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1749238) /Source="Nicolas_upshifts" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1749252..1749258) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1749269..1749844) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389788.1" /db_xref="EnsemblGenomes-Gn:BSU19070" /db_xref="EnsemblGenomes-Tr:CAB13799" /db_xref="GOA:O34892" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025996" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG13510" /db_xref="UniProtKB/Swiss-Prot:O34892" /translation="MSPRIGLTQKMIVDAAAEIADQEGVNGVSLAALSKKMNVRPPSL YNHINGLQAIRAELAVRGLTKLFDQMADSVTERKGDSAMLSLAHAYVDFAIENPGYYE AALLKVHDKRTEIVSDQIVCLVTKLLIENGYASEKTAIHATRGLRSLLHGFTVLIAKE AFEREEDILESLSFSIRTFLSGLLINNKNIM*" /label="yobS CDS" gene complement(1749269..1749844) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /label="yobS gene" CDS complement(1749850..1750551) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_389789.1" /db_xref="EnsemblGenomes-Gn:BSU19080" /db_xref="EnsemblGenomes-Tr:CAB13800" /db_xref="GOA:O34910" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13511" /db_xref="UniProtKB/Swiss-Prot:O34910" /translation="MRITQYQTVWQLTFFPALFPVNCYLVEEENEVTLIDAALPGSYK GIIQAVNQLGKPLQHILLTHAHGDHVGSLDTLAQTFPHAKVMISERDSFLLQGDTSLR QDEPQTPIKGGIPKHIQTKPHQLLTGGETIGSLLAIPTPGHTPGSMSFLDTRNGTLIA GDAFQLRGGIAVSGQIKWAFPFPAFATWNKEEAIKSAQLLADKAPSCLAVGHGKFLRS PSERMRQAIQKAKKG*" /label="yobT CDS" gene complement(1749850..1750551) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /label="yobT gene" promotor_-10 complement(1750581..1750600) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1750581) /Source="Nicolas_upshifts" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1750585..1750600) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1750615..1750622) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1750615..1750622) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1750625) /Source="Nicolas_upshifts" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1750628..1751110) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative effector of transcriptional regulator" /protein_id="NP_389790.1" /db_xref="EnsemblGenomes-Gn:BSU19090" /db_xref="EnsemblGenomes-Tr:CAB13801" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG13512" /db_xref="UniProtKB/Swiss-Prot:O34637" /translation="MGFSHITHLDLKRFAGLSQRTSNALEMTEERRIPALWDQLWKQD MSALLSQAEKDKSIIALYSNYEQETNGFYTFSVGTFQEYDDILPGPYENIDLPASAYA VFTSRIGPIEEIVLETWKEIWTWDKRHLRTFTGDFEMYDQNAAVPQRAQVNIYVAIKK *" /label="yobU CDS" gene complement(1750628..1751110) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /label="yobU gene" misc_feature complement(1751149..1751166) /Source="Nicolas_upshift_promotors" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1751153) /Source="Nicolas_upshifts" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1751164..1752105) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389791.1" /db_xref="EnsemblGenomes-Gn:BSU19100" /db_xref="EnsemblGenomes-Tr:CAB13802" /db_xref="GOA:O34920" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026881" /db_xref="InterPro:IPR028349" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13513" /db_xref="UniProtKB/Swiss-Prot:O34920" /translation="MKLERLLAMVVLLISKKQVQAAELAELFEVSVRTIYRDIETINR AGIPIVTSQGSGGGIGIMETYRLEREWLKEEELFAIASALQSVSSMYEPVSHSTAYQK IKHLIPEQSTQAFKHQTEKWFIDMTAWGHTEDQKTLREKISAAIDRLLTISFTYTSAS GETLLRETEPYTLVCKAGHWYLYAYCLVRNDFRFFKLNRMKDLAILHQTFIRKDIQLD TLPWDKSWYQKDRLTELVILVQPSARQRIGEWFGYDVLHCCEEDEICQAVISLPEDQW LIGFLLQFGKDIEVLQPLHIRDKVKETIHHMQKIYET*" /label="yobV CDS" gene complement(1751164..1752105) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /label="yobV gene" downshifts complement(1751197) /Source="Nicolas_upshifts" /id="D1046" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="0.95712" /MaxDrop="3.62763" /score="-3.71616684" /energy="-9" /TU="NA" /idTUdmin="U1548" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1752135..1752154) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1752143) /Source="Nicolas_upshifts" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1752168..1752172) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1752176..1752185 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1752198..1752217 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1752206 /Source="Nicolas_upshifts" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="upshifts" S_feature 1752221..1752285 /Source="Nicolas_S_feature" /locus_tag="new_2084124_2084188" /HighExp="BT, S7, B36, S8, S6, Pyr, G/S, B60, Glucon, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S729" promotor_-35 1752257..1752262 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1752278..1752296 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1752287 /Source="Nicolas_upshifts" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="upshifts" CDS 1752311..1752856 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8990290, 11717295, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 11717295, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="mother cell-specific membrane sporulation protein" /protein_id="NP_389792.1" /db_xref="EnsemblGenomes-Gn:BSU19110" /db_xref="EnsemblGenomes-Tr:CAB13803" /db_xref="GOA:P94497" /db_xref="InterPro:IPR014743" /db_xref="SubtiList:BG12269" /db_xref="UniProtKB/Swiss-Prot:P94497" /translation="MHLTLQSVYPAIIIIFFLYKKIKRSIGYQPLKPRWLFTRIILFS LFAFGLSIFSAIHPFLYGYLILGILGGWLLVFFAKKNISFEKRRGKIYFRTHIWVEVI LLTLFLSRFLYRVTELYLTSPDLNRLGSYSQSIGTDPLTIGVCFLIAVYYIGFSSFII KLSRNELEQHEYNKEKDILAR*" /label="yobW CDS" gene 1752311..1752856 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /label="yobW gene" downshifts 1752815 /Source="Nicolas_upshifts" /id="D1047" /incds=0 /nref=20 /ntot=63 /MaxReadThrough="3.56215" /MaxDrop="4.5413" /score="-4.21976438" /energy="-17.7" /TU="U1552,U1553" /idTUdmin="U1552" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS complement(1752883..1753206) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15948947, 16406068, 16430705, 19170879, 19995076, 25213752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16406068, 16430705, 19170879, 19995076, 25213752; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressor favouring Zn2+)" /protein_id="NP_389793.1" /db_xref="EnsemblGenomes-Gn:BSU19120" /db_xref="EnsemblGenomes-Tr:CAB13804" /db_xref="GOA:O31844" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13748" /db_xref="UniProtKB/Swiss-Prot:O31844" /translation="MTEFRETEQSAADLDEETLFLVAQTFKALSDPTRIRILHLLSQG EHAVNGIAEKLNLLQSTVSHQLRFLKNLRLVKSRREGTSIYYSPEDEHVLDVLQQMIH HTQHD*" /label="czrA CDS" gene complement(1752883..1753206) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /label="czrA gene" downshifts complement(1752890) /Source="Nicolas_upshifts" /id="D1048" /incds=0 /nref=73 /ntot=252 /MaxReadThrough="1.89304" /MaxDrop="4.873" /score="17.3750937" /energy="-18.6" /TU="NA" /idTUdmin="U1554" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1753227..1753246) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1753238) /Source="Nicolas_upshifts" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1753259..1753266) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1753327..1753333 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1753344 /Source="Nicolas_upshifts" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1753348..1753367 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1753400..1754077 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative murein fragments glycosidase" /protein_id="NP_389794.1" /db_xref="EnsemblGenomes-Gn:BSU19130" /db_xref="EnsemblGenomes-Tr:CAB13805" /db_xref="GOA:O34636" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13514" /db_xref="UniProtKB/Swiss-Prot:O34636" /translation="MKKKRKGCFAAAGFMMIFVFVIASFLLVLLFFNRDLIKKLPIDT KTIVLERLTDYKPLVEEELESQGLSNYTSLILGMMYQESKGKGNDPMQSSESLGLKRN EITDPQLSVKQGIKQFTLMYKTGKEKGVDLDTIIQSYNMGAGYIDFVAEHGGTHTEEL AKQYSEQQVKKNPDLYTCGGNAKNFRYPYCYGDYTYAEKVKEKTKTVEESLQVATLET MESKAHE*" /label="yocA CDS" gene 1753400..1754077 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /label="yocA gene" downshifts 1754069 /Source="Nicolas_upshifts" /id="D1049" /incds=0 /nref=207 /ntot=268 /MaxReadThrough="3.9729" /MaxDrop="8.52704" /score="-4.21976438" /energy="-17.7" /TU="U1555" /idTUdmin="U1555" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1754167..1754703) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19222757, 24214949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389795.1" /db_xref="EnsemblGenomes-Gn:BSU19140" /db_xref="EnsemblGenomes-Tr:CAB13806" /db_xref="GOA:O31845" /db_xref="InterPro:IPR007352" /db_xref="InterPro:IPR013833" /db_xref="SubtiList:BG13749" /db_xref="UniProtKB/Swiss-Prot:O31845" /translation="MNQTENKPKNYTGIVLTLTVLINGLIAVLFFMPKLDQFSHANIH ILPMLNAIFNSFTFIFLLAALIMIKQKNIKAHKRFILAAFTTTLLFLICYVTYHSIAE NTLYGGEGIMRPIYFFILITHICLSAIIVPLALFTLIRGFSMQVERHKKIARWTMPLW LYVSLTGVIVYLMISPYY*" /label="yozB CDS" gene complement(1754167..1754703) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /label="yozB gene" downshifts complement(1754190) /Source="Nicolas_upshifts" /id="D1050" /incds=0 /nref=175 /ntot=250 /MaxReadThrough="4.33842" /MaxDrop="7.96098" /score="14.7470642" /energy="-7.7" /TU="U1556" /idTUdmin="U1557" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1754730..1754749) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1754750) /Source="Nicolas_upshifts" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1754763..1754770) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1754840..1755622) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389796.1" /db_xref="EnsemblGenomes-Gn:BSU19150" /db_xref="EnsemblGenomes-Tr:CAB13807" /db_xref="SubtiList:BG13515" /db_xref="UniProtKB/Swiss-Prot:O34516" /translation="MAIDSLINKLQYVQLEPPDKILSLYLNTDMRDPEQQGGEWKIAL KSGFSRLKEYLAASDPEEEKCLDGIRAKMNQYLNAMGKDMPRSLVFFVSDSGIWEPIK LQVPVDTRFYWEETAVLDQLKGLRQTYPSTAFILTQQHEVKIIETVLGKIEAVERYEY DMINESWKNSHSAVDKAPPFEENRMREHVTENQSRLYKRLAASLDQKAAAKRWERMVI AGDKETADILDQHMNKPIHSKIQKNLLNENEHKVIEHLIKEA*" /label="yocB CDS" gene complement(1754840..1755622) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /label="yocB gene" downshifts complement(1754849) /Source="Nicolas_upshifts" /id="D1051" /incds=0 /nref=3 /ntot=38 /MaxReadThrough="5.37496" /MaxDrop="4.00348" /score="14.7470642" /energy="-7.7" /TU="U1557" /idTUdmin="U1557" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1755644..1755662) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1755663) /Source="Nicolas_upshifts" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1755676..1755682) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1755719..1755726 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1755741..1755760 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1755745 /Source="Nicolas_upshifts" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1755793..1756290 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389797.1" /db_xref="EnsemblGenomes-Gn:BSU19160" /db_xref="EnsemblGenomes-Tr:CAB13808" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13516" /db_xref="UniProtKB/Swiss-Prot:O35042" /translation="MFTVKEKNRQELEEELNDLEFQIYRMQENMKDLSKDAKVLGIDQ SKHDEWMIVSSIDDGQTCKIMLTDCKTAYRGKGCFSLVASYKDDAIHIGDIKGPPNHG FGSICMKYLKDIARDHNIPKVTGDIAKRDWNHVDRLIHFYEKHHFKVCIDHDTQSGSI KWVDL*" /label="yocC CDS" gene 1755793..1756290 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /label="yocC gene" promotor_-35 1756297..1756300 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1756316..1756335 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1756318 /Source="Nicolas_upshifts" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1756354..1757331 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /EC_number="3.4.17.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22516613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxypeptidase; aminoacid adenylate hydrolase (microcin resistance)" /protein_id="NP_389798.1" /db_xref="EnsemblGenomes-Gn:BSU19170" /db_xref="EnsemblGenomes-Tr:CAB13809" /db_xref="GOA:O35046" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13517" /db_xref="UniProtKB/Swiss-Prot:O35046" /translation="MYASKLKKGDEIRIVSPATSMSILSNEAKIQAKTALERLGYRVT IAEHANECNEFDSSSIESRVHDLHAAFFDPGVKAILTTLGGFNSNQLLRYLDYEKIKR HPKILCGYSDITALCNAIYQKTGLVTYSGPHFSTFAMKKGLDYTEEYFLSCCASDDPF EIHPSSEWSDDRWFLDQENRRFYPNNGPVVIQEGYAEGTLIGGNLCTLNLLQGTEYFP ETEHTILLIEDDYMSDIHMFDRDLQSLIHLPAFSHVKAILIGRFQKASNVSIDLVKAM IETKKELSGIPIIANINAGHTSPIATFPIGGTCRIEAISGTSRIWIDKH*" /label="yocD CDS" gene 1756354..1757331 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /label="yocD gene" downshifts 1757303 /Source="Nicolas_upshifts" /id="D1052" /incds=0 /nref=131 /ntot=256 /MaxReadThrough="3.77491" /MaxDrop="4.2254" /score="1.66373432" /energy="-9.5" /TU="U1558,U1559" /idTUdmin="U1558" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 1757428..1757435 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1757450..1757469 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1757457 /Source="Nicolas_upshifts" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1757493..1758551 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /EC_number="1.14.19.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid desaturase" /protein_id="NP_389799.1" /db_xref="EnsemblGenomes-Gn:BSU19180" /db_xref="EnsemblGenomes-Tr:CAB13810" /db_xref="GOA:O34653" /db_xref="InterPro:IPR005804" /db_xref="SubtiList:BG13518" /db_xref="UniProtKB/Swiss-Prot:O34653" /translation="MTEQTIAHKQKQLTKQVAAFAQPETKNSLIQLLNTFIPFFGLWF LAYLSLDVSYLLTLALTVIAAGFLTRIFIIFHDCCHQSFFKQKRYNHILGFLTGVLTL FPYLQWQHSHSIHHATSSNLDKRGTGDIWMLTVNEYKAASRRTKLAYRLYRNPFIMFI LGPIYVFLITNRFNKKGARRKERVNTYLTNLAIVALAAACCLIFGWQSFLLVQGPIFL ISGSIGVWLFYVQHTFEDSYFEADENWSYVQAAVEGSSFYKLPKLLQWLTGNIGYHHV HHLSPKVPNYKLEVAHEHHEPLKNVPTITLKTSLQSLAFRLWDEDNKQFVSFRAIKHI PVSLPPDSPEKQKLRKNA*" /label="desE CDS" gene 1757493..1758551 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /label="desE gene" S_feature 1758552..1758621 /Source="Nicolas_S_feature" /locus_tag="new_2090455_2090524" /HighExp="Cold, S8, LoTm, Sw, Paraq, BC, S7, S0, Oxctl, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.859" /TUlongSig="SigA, SigA" /TUlongPSig="0.984, 1" /label="S730" promotor_-35 1758605..1758611 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1758623..1758642 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1758623 /Source="Nicolas_upshifts" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1758671..1759783 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component thermosensor histidine kinase [DesR-DesK]" /protein_id="NP_389800.1" /db_xref="EnsemblGenomes-Gn:BSU19190" /db_xref="EnsemblGenomes-Tr:CAB13811" /db_xref="GOA:O34757" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="PDB:3EHF" /db_xref="PDB:3EHG" /db_xref="PDB:3EHH" /db_xref="PDB:3EHJ" /db_xref="PDB:3GIE" /db_xref="PDB:3GIF" /db_xref="PDB:3GIG" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUM" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13519" /db_xref="UniProtKB/Swiss-Prot:O34757" /translation="MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGII LTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERV PFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERL EEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAAR ELKSVQQTARTSLNEVRKIVSSMKGIRLKDELINIKQILEAADIMFIYEEEKWPENIS LLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKG HGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK*" /label="desK CDS" gene 1758671..1759783 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /label="desK gene" CDS 1759802..1760401 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [DesK]" /protein_id="NP_389801.1" /db_xref="EnsemblGenomes-Gn:BSU19200" /db_xref="EnsemblGenomes-Tr:CAB13812" /db_xref="GOA:O34723" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:4LDZ" /db_xref="PDB:4LE0" /db_xref="PDB:4LE1" /db_xref="PDB:4LE2" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13520" /db_xref="UniProtKB/Swiss-Prot:O34723" /translation="MISIFIAEDQQMLLGALGSLLNLEDDMEVVGKGTTGQDAVDFVK KRQPDVCIMDIEMPGKTGLEAAEELKDTGCKIIILTTFARPGYFQRAIKAGVKGYLLK DSPSEELANAIRSVMNGKRIYAPELMEDLYSEANPLTDREKEVLELVADGKNTKEIAQ ELSIKSGTVRNYISMILEKLEVKNRIEAITRSKEKGWFK*" /label="desR CDS" gene 1759802..1760401 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /label="desR gene" downshifts 1760339 /Source="Nicolas_upshifts" /id="D1053" /incds=1 /nref=1 /ntot=41 /MaxReadThrough="4.44811" /MaxDrop="2.78724" /score="23.648858" /energy="-15.4" /TU="U1560" /idTUdmin="U1560" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1760383 /Source="Nicolas_upshifts" /id="D1054" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.88273" /MaxDrop="3.38398" /score="23.648858" /energy="-15.4" /TU="NA" /idTUdmin="U1560" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1760423..1760921) /Source="Nicolas_S_feature" /locus_tag="new_2092326_2092824_c" /HighExp="S4, LoTm, S6, S3, S5, S8, S7, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.230296" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S731" downshifts complement(1760459) /Source="Nicolas_upshifts" /id="D1055" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.62146" /MaxDrop="5.61121" /score="23.7393309" /energy="-12.4" /TU="NA" /idTUdmin="U1563" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1760893..1760902 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1760905..1760923) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1760914..1761108 /Source="Nicolas_S_feature" /locus_tag="new_2092817_2093011" /HighExp="S6, S8, S7, BT, B36, Pyr, G/S, C30, S5, B60" /AntisenseName="yocH" /AntisenseCor="0.113870403460631" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S732" upshifts 1760914 /Source="Nicolas_upshifts" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1760915..1760934 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1760921) /Source="Nicolas_upshifts" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1760940..1760945) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1760996..1761859) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /EC_number="3.2.1.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:17307850, 20070526, 20487291, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17307850, 20070526, 20487291, 26102633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported cell wall lytic enzyme" /protein_id="NP_389802.1" /db_xref="EnsemblGenomes-Gn:BSU19210" /db_xref="EnsemblGenomes-Tr:CAB13813" /db_xref="GOA:O34669" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG13521" /db_xref="UniProtKB/Swiss-Prot:O34669" /translation="MKKTIMSFVAVAALSTTAFGAHASAKEITVQKGDTLWGISQKNG VNLKDLKEWNKLTSDKIIAGEKLTISSEETTTTGQYTIKAGDTLSKIAQKFGTTVNNL KVWNNLSSDMIYAGSTLSVKGQATAANTATENAQTNAPQAAPKQEAVQKEQPKQEAVQ QQPKQETKAEAETSVNTEEKAVQSNTNNQEASKELTVTATAYTANDGGISGVTATGID LNKNPNAKVIAVDPNVIPLGSKVYVEGYGEATAADTGGAIKGNKIDVFVPSKSDASNW GVKTVSVKVLN*" /label="walL CDS" gene complement(1760996..1761859) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /label="walL gene" downshifts complement(1761009) /Source="Nicolas_upshifts" /id="D1056" /incds=0 /nref=227 /ntot=262 /MaxReadThrough="2.55593" /MaxDrop="7.59881" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 1761065 /Source="Nicolas_upshifts" /id="D1057" /incds=1 /nref=8 /ntot=28 /MaxReadThrough="6.14664" /MaxDrop="3.95582" /score="23.648858" /energy="-15.4" /TU="U1562" /idTUdmin="U1560" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1761097) /Source="Nicolas_upshifts" /id="D1058" /incds=1 /nref=10 /ntot=161 /MaxReadThrough="7.34609" /MaxDrop="3.8459" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" S_feature 1761110..1761877 /Source="Nicolas_S_feature" /locus_tag="new_2093013_2093780" /HighExp="BT, S8, S6, Gly, S7, C30, G135, G/S, Fru, Pyr" /AntisenseName="yocH" /AntisenseCor="-0.12155468325348801" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S733" promotor_-35 1761855..1761859 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1761868..1761882 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1761879 /Source="Nicolas_upshifts" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1761898..1761917) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1761911) /Source="Nicolas_upshifts" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1761913..1762106) /Source="Nicolas_S_feature" /locus_tag="new_2093816_2094009_c" /HighExp="LoTm, HiOs, S8, C30, S2, G135, G180, T5.0H, S7, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S734" promotor_-35 complement(1761929..1761935) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1762107..1763882) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /EC_number="3.6.1.12" /experiment="publication(s) with functional evidences, PMID:11886746, 16385024, 22200572, 25246477, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 16385024, 22200572, 25246477, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase" /protein_id="NP_389803.1" /db_xref="EnsemblGenomes-Gn:BSU19220" /db_xref="EnsemblGenomes-Tr:CAB13814" /db_xref="GOA:O34748" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002121" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR006293" /db_xref="InterPro:IPR010997" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018982" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032284" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13522" /db_xref="UniProtKB/Swiss-Prot:O34748" /translation="MLHRAQSLLAHYFGYEKFRSGQDEAIRLVTEARQNTACIMPTGG GKSICYQIPALMFEGTTIVISPLISLMKDQVDALEEAGINAAYINSTQSNQEIYERLN GLKEGAYKLFYITPERLTSIEFIRILQGIDVPLVAIDEAHCISQWGHDFRPSYRNIEI LFRELHDKPVIMALTATATPEVHDDICKQLHIQKENTVYTGFSRENLTFKVVKGENKD RFIDEYVQNNRHEAGIVYTATRKEADRIYERLKRNQVRAGRYHGGLADDVRKEQQERF LNDELQVMVATSAFGMGIDKSNIRFVLHAQIPKDMESYYQEAGRAGRDGLASECVLLF SPQDIMVQRFLIEQSEHEEKQKQDLKKLRQMVDYCHTEDCLQRFILMYFGEKEPDACG QCGNCTDTRAAHDVTREAQMVLSCIIRMKERFGKTMVAQVLAGSKNKKVLENGFSDLS TYGILKHQSVGEISDFIEFLISDDFIRMSDGTFPTLFVSSKGRNVLKGELSVARKEAL KAAAITENDELFERLRMVRKEIAAEQGVPPFVVFSDQTLKEMSGKQPVNDDELLSIKG VGEQKRAKYGRLFLQEIQAYARMTD*" /label="recQ CDS" gene complement(1762107..1763882) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /label="recQ gene" S_feature complement(1763883..1764013) /Source="Nicolas_S_feature" /locus_tag="new_2095786_2095916_c" /HighExp="LoTm, G180, Cold, G135, G150, T5.0H, T4.0H, T3.30H, S2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S735" misc_RNA complement(1764006..1764208) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /product="6Sa RNA" /experiment="publication(s) with functional evidences, PMID:11886746, 15793584, 15811922, 22333917, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 15793584, 15811922, 22333917, 25576829, 26873600; Product type n : RNA" /label="ssrSA RNA" gene complement(1764006..1764208) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /label="ssrSA gene" downshifts complement(1764058) /Source="Nicolas_upshifts" /id="D1059" /incds=0 /nref=34 /ntot=297 /MaxReadThrough="4.06142" /MaxDrop="7.97725" /score="26.8190437" /energy="-12.7" /TU="U1566" /idTUdmin="U1568" /TUdmin=163 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1764206..1764225) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-10" upshifts complement(1764224) /Source="Nicolas_upshifts" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="upshifts" S_feature complement(1764226..1764418) /Source="Nicolas_S_feature" /locus_tag="new_2096129_2096321_c" /HighExp="dia5, Etha, dia15, Diami, S8, S7, C30, G180, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S736" promotor_-35 complement(1764238..1764245) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-35" CDS complement(1764447..1765073) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /EC_number="1.7.-.-" /experiment="publication(s) with functional evidences, PMID:11886746, 18208493, 22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 18208493, 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-dependent NADH-azoreductase" /protein_id="NP_389804.1" /db_xref="EnsemblGenomes-Gn:BSU19230" /db_xref="EnsemblGenomes-Tr:CAB13815" /db_xref="GOA:O35022" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13523" /db_xref="UniProtKB/Swiss-Prot:O35022" /translation="MSTVLFVKSSDRTAEEGVSTKLYEAFLAAYKENNPNDEVVELDL HKENLPYLGRDMINGTFKAGQGMEMTEDEKKQAAIADKYLNQFVKADKVVFAFPLWNF TVPAVLHTYVDYLSRAGVTFKYTQEGPVGLMGGKKVALLNARGGVYSEGPMAALEMSL NFMKTVLGFWGVQDLHTVVIEGHNAAPDQAQEIVEKGLQEAKDLAAKF*" /label="azoJ CDS" gene complement(1764447..1765073) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /label="azoJ gene" downshifts complement(1764463) /Source="Nicolas_upshifts" /id="D1060" /incds=0 /nref=68 /ntot=205 /MaxReadThrough="5.10353" /MaxDrop="5.66408" /score="1.15982687" /energy="-10.9" /TU="U1567,U1568" /idTUdmin="U1567" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1765107..1765126) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-10" upshifts complement(1765120) /Source="Nicolas_upshifts" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="upshifts" promotor_-35 complement(1765140..1765147) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-35" CDS complement(1765224..1765715) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 15496987, 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_389805.2" /db_xref="EnsemblGenomes-Gn:BSU19240" /db_xref="EnsemblGenomes-Tr:CAB13816" /db_xref="GOA:P80872" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR020458" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG13524" /db_xref="UniProtKB/Swiss-Prot:P80872" /translation="MALTKEQTQHLYHKLLDMQKELSGEKKETESMTEEVGELSNGVD NHMADHGTLVTDRMTDQTVKEIDRELLEEVNRALQKMKDGTYGVCEKTGQEIPYERLE AVPYARMTVEAQADVEDDLETDAPSYEREFHEQVKDLSNKETIDQKSSQTYEILDREQ DSK*" /label="yocK CDS" gene complement(1765224..1765715) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /label="yocK gene" downshifts complement(1765233) /Source="Nicolas_upshifts" /id="D1061" /incds=0 /nref=5 /ntot=49 /MaxReadThrough="7.79466" /MaxDrop="4.30433" /score="1.15982687" /energy="-10.9" /TU="U1568,U1573" /idTUdmin="U1571" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1765727..1765745) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-10" upshifts complement(1765739) /Source="Nicolas_upshifts" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="upshifts" promotor_-35 complement(1765759..1765765) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-35" CDS complement(1765790..1766122) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389806.1" /db_xref="EnsemblGenomes-Gn:BSU19250" /db_xref="EnsemblGenomes-Tr:CAB13817" /db_xref="SubtiList:BG13525" /db_xref="UniProtKB/Swiss-Prot:O34976" /translation="MKKMFRSLIRHCLKPELDKLRECEERLSVIEKQKQSSKQESEET YIHIETLNVEKVDYHLEFGELTIDELSGRLNIGATYYIPPEEKDKKCQRKPEAPSTPA VTIRSKRQ*" /label="yocL CDS" gene complement(1765790..1766122) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /label="yocL gene" S_feature complement(1766123..1766413) /Source="Nicolas_S_feature" /locus_tag="new_2098025_2098315_c" /HighExp="Salt, Cold, S3, S8, S4, S7, T5.0H, T3.30H, S6, T4.0H" /AntisenseName="yoyB" /AntisenseCor="0.489341986454357" /AntisenseRegPval="-16.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S737" promotor_-35 1766138..1766143 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-35" promotor_-10 1766158..1766176 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-10" upshifts 1766160 /Source="Nicolas_upshifts" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="upshifts" CDS 1766200..1766427 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097740.1" /db_xref="EnsemblGenomes-Gn:BSU19259" /db_xref="EnsemblGenomes-Tr:CAX52637" /db_xref="UniProtKB/Swiss-Prot:C0H429" /translation="MLPTNINISHLKTNSIGTGSSLTFGSAELRNRCSAIKRNNGFGE QNADGIVMVIPIESIDDRDVSDALSMKINHQ*" /label="yoyB CDS" gene 1766200..1766427 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /label="yoyB gene" CDS complement(1766414..1766890) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11150673, 23155385; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_389808.1" /db_xref="EnsemblGenomes-Gn:BSU19260" /db_xref="EnsemblGenomes-Tr:CAB13818" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG13526" /db_xref="UniProtKB/Swiss-Prot:O34321" /translation="MDFEKMKQWMEFAQQMYGGDFWKQVFDEDQKTPFMTNGQSPFPF AQQDQRGKGDASFPSMDIVDTVAEVQFLIYLPGYRKQDVHILSYGDYLVVKGQRFSYF NEQDFRQKEGKYGSFEKKIPLSDHLHGKMNAIFKDGILYITIQKDEGQAKTIVIDD*" /label="yocM CDS" gene complement(1766414..1766890) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /label="yocM gene" S_feature 1766428..1766935 /Source="Nicolas_S_feature" /locus_tag="new_2098330_2098837" /HighExp="S6, S5, S8, S7, S4, B36, BT, S3, T5.0H, LoTm" /AntisenseName="yocM" /AntisenseCor="0.54530996552252997" /AntisenseRegPval="-21.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.877" /TUlongSig="NA" /TUlongPSig="NA" /label="S738" S_feature complement(1766891..1766993) /Source="Nicolas_S_feature" /locus_tag="new_2098793_2098895_c" /HighExp="Cold, Salt, S8, T5.0H, S3, T-0.40H, T0.0H, S4, T4.0H, S6" /AntisenseName="yozN" /AntisenseCor="0.471443110130365" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S739" promotor_-35 1766908..1766913 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1766928..1766946 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1766937 /Source="Nicolas_upshifts" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="upshifts" CDS 1766957..1767220 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (mother cell in sporulation)" /protein_id="NP_389809.1" /db_xref="EnsemblGenomes-Gn:BSU19270" /db_xref="EnsemblGenomes-Tr:CAB13819" /db_xref="SubtiList:BG13761" /db_xref="UniProtKB/Swiss-Prot:O31846" /translation="MVQPTPYININIFMLKINSFENASAVNVGQNLLAEWQNSDKKNQ GYGQNFGDASGFMGTRSHVDDRDQIDSPASFESEAVNSSIKRK*" /label="yozN CDS" gene 1766957..1767220 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /label="yozN gene" promotor_-10 complement(1766973..1766992) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1766993) /Source="Nicolas_upshifts" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1766995..1767520) /Source="Nicolas_S_feature" /locus_tag="new_2098897_2099422_c" /HighExp="Salt, Cold, T-0.40H, T0.0H, T0.30H, T-1.10H, T-1.40H, T3.30H, T2.0H, S0" /AntisenseName="yocN" /AntisenseCor="-0.51964820699949898" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S740" promotor_-35 complement(1767006..1767010) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1767225..1767458 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (sporulation-related)" /protein_id="NP_389810.1" /db_xref="EnsemblGenomes-Gn:BSU19280" /db_xref="EnsemblGenomes-Tr:CAB13820" /db_xref="SubtiList:BG13527" /db_xref="UniProtKB/Swiss-Prot:O34855" /translation="MFFSPSVVNVGGFKINTMDRGSSLTLGPYQQVDYFLSAKINQGF GEENGDFTPLVVPISNVLDADLVDSNSAKNSVV*" /label="yocN CDS" gene 1767225..1767458 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /label="yocN gene" downshifts 1767445 /Source="Nicolas_upshifts" /id="D1062" /incds=0 /nref=62 /ntot=90 /MaxReadThrough="2.0117" /MaxDrop="7.59451" /score="5.68120132" /energy="-10.9" /TU="NA" /idTUdmin="U1570" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1767544..1767888) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved hypothetical phage protein" /protein_id="NP_389811.1" /db_xref="EnsemblGenomes-Gn:BSU19290" /db_xref="EnsemblGenomes-Tr:CAB13821" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG13762" /db_xref="UniProtKB/Swiss-Prot:O31847" /translation="MGIFSVSRSTDAKKLEALLVEGERIESIYKLRVDQICFTNKRII FFDNKMFSKKKVRVFLPYKTIESFAIQEAGMFDPDTGLLLMTRSKTFELEFAKDTDLS EVQAVLTKHLCS*" /label="yozO CDS" gene complement(1767544..1767888) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /label="yozO gene" downshifts complement(1767565) /Source="Nicolas_upshifts" /id="D1063" /incds=0 /nref=61 /ntot=217 /MaxReadThrough="4.58642" /MaxDrop="4.1868" /score="12.6520239" /energy="-9.6" /TU="U1572,U1573" /idTUdmin="U1574" /TUdmin=616 /isTUend="FALSE" /label="downshifts" S_feature complement(1767889..1767961) /Source="Nicolas_S_feature" /locus_tag="new_2099791_2099863_c" /HighExp="T0.30H, T0.0H, T1.0H, T-0.40H, T1.30H, T-1.10H, Salt, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S741" promotor_-10 complement(1767957..1767976) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1767961) /Source="Nicolas_upshifts" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1767963..1768066) /Source="Nicolas_S_feature" /locus_tag="new_2099865_2099968_c" /HighExp="T0.30H, T0.0H, T-0.40H, T1.0H, T1.30H, Salt, T-1.10H, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S742" promotor_-35 complement(1767990..1767995) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1768053..1768068) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1768066) /Source="Nicolas_upshifts" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1768081..1768090) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1768209) /Source="Nicolas_upshifts" /id="D1064" /incds=0 /nref=117 /ntot=269 /MaxReadThrough="5.5406" /MaxDrop="6.72115" /score="36.7697843" /energy="-10.7" /TU="U1574" /idTUdmin="U1576" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1768245..1768448) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389812.1" /db_xref="EnsemblGenomes-Gn:BSU19300" /db_xref="EnsemblGenomes-Tr:CAB13822" /db_xref="SubtiList:BG13750" /db_xref="UniProtKB/Swiss-Prot:O31848" /translation="MIHKNWLEKETIKKVKCVQTNAKKYIVNRVLTPGKEYEVKNETE EFLFVVDNTNKVGGYYKEYFEEM*" /label="yozC CDS" gene complement(1768245..1768448) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /label="yozC gene" promotor_-10 complement(1768469..1768488) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1768487) /Source="Nicolas_upshifts" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1768489..1768555) /Source="Nicolas_S_feature" /locus_tag="new_2100391_2100457_c" /HighExp="S7, S8, S6, S5, C30, S4, T4.0H, B60, BC, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.461" /TUlongSig="NA" /TUlongPSig="NA" /label="S743" promotor_-35 complement(1768504..1768511) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1768521..1768528 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-35" upshifts 1768540 /Source="Nicolas_upshifts" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="upshifts" misc_feature complement(1768542..1768554) /Source="Nicolas_upshift_promotors" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1768542..1768561 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-10" S_feature 1768545..1768677 /Source="Nicolas_S_feature" /locus_tag="new_2100447_2100579" /HighExp="BC, M0t90, M9-stat, S2, T2.30H, Sw, Lbstat, M40t90, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S744" upshifts complement(1768566) /Source="Nicolas_upshifts" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="upshifts" CDS 1768678..1770165 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /EC_number="1.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17555270, 23874669, 25409630, 26337367, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17555270, 23874669, 25409630, 26337367, 27797724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxypropionaldehyde dehydrogenase" /protein_id="NP_389813.1" /db_xref="EnsemblGenomes-Gn:BSU19310" /db_xref="EnsemblGenomes-Tr:CAB13823" /db_xref="GOA:O34660" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12582" /db_xref="UniProtKB/Swiss-Prot:O34660" /translation="MSSLTMQVTKRLETFLQGTKKLYIDGKFVPSASGATFDTPNPAT GETLMTLYEAQAADVDKAVKAARKAFDQGEWRTMSPASRSRLMYKLADLMEEHKTELA QLETLDNGKPINETTNGDIPLAIEHMRYYAGWCTKITGQTIPVSGAYFNYTRHEPVGV VGQIIPWNFPLLMAMWKMGAALATGCTIVLKPAEQTPLSALYLAELIDQAGFPAGVIN IIPGFGEDAGEALTNHEAVDKIAFTGSTEIGKKIMSTAAKSIKRVTLELGGKSPNILL PDANLKKAIPGALNGVMFNQGQVCCAGSRVFIHKDQYDEVVDEMASYAESLRQGAGLH KDTQIGPLVSKEQHERVLSYIQKGKDEGAKAVTGGSCPFEAGYFVAPTVFANVEDEMT IAKEEIFGPVLTAIPYETVDEVIERANHSEYGLAAGLWTENVKQAHYIADRLQAGTVW VNCYNVFDAASPFGGYKQSGLGREMGSYALDNYTEVKSVWVNLED*" /label="dhaS CDS" gene 1768678..1770165 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /label="dhaS gene" promotor_-10 complement(1769121..1769138) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1769127) /Source="Nicolas_upshifts" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1769151..1769159) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1770151 /Source="Nicolas_upshifts" /id="D1065" /incds=0 /nref=163 /ntot=260 /MaxReadThrough="3.66831" /MaxDrop="7.01026" /score="24.6079855" /energy="-7.1" /TU="U1575" /idTUdmin="U1575" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1770213..1770218 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1770234..1770252 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1770239 /Source="Nicolas_upshifts" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="upshifts" CDS 1770266..1772164 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /EC_number="4.2.1.137" /EC_number="5.4.99.17" /function="16.13: Shape" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2253626, 18436644, 18630919, 21627333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2253626, 18436644, 18630919, 21627333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="squalene-hopene cyclase, sporulenol synthase (spore protection)" /protein_id="NP_389814.2" /db_xref="EnsemblGenomes-Gn:BSU19320" /db_xref="EnsemblGenomes-Tr:CAB13824" /db_xref="GOA:Q796C3" /db_xref="InterPro:IPR008930" /db_xref="InterPro:IPR018333" /db_xref="InterPro:IPR032696" /db_xref="InterPro:IPR032697" /db_xref="SubtiList:BG12679" /db_xref="UniProtKB/Swiss-Prot:Q796C3" /translation="MGTLQEKVRRFQKKTITELRDRQNADGSWTFCFEGPIMTNSFFI LLLTSLDEGENEKELISSLAAGIHAKQQPDGTFINYPDETRGNLTATVQGYVGMLASG CFHRTEPHMKKAEQFIISHGGLRHVHFMTKWMLAANGLYPWPALYLPLSLMALPPTLP IHFYQFSSYARIHFAPMAVTLNQRFVLINRNISSLHHLDPHMTKNPFTWLRSDAFEER DLTSILLHWKRVFHAPFAFQQLGLQTAKTYMLDRIEKDGTLYSYASATIYMVYSLLSL GVSRYSPIIRRAITGIKSLVTKCNGIPYLENSTSTVWDTALISYALQKNGVTETDGSV TKAADFLLERQHTKIADWSVKNPNSVPGGWGFSNINTNNPDCDDTTAVLKAIPRNHSP AAWERGVSWLLSMQNNDGGFSAFEKNVNHPLIRLLPLESAEDAAVDPSTADLTGRVLH FLGEKVGFTEKHQHIQRAVKWLFEHQEQNGSWYGRWGVCYIYGTWAALTGMHACGVDR KHPGIQKALRWLKSIQNDDGSWGESCKSAEIKTYVPLHRGTIVQTAWALDALLTYENS EHPSVVKGMQYLTDSSSHSADSLAYPAGIGLPKQFYIRYHSYPYVFSLLAVGKYLDSI EKETANET*" /label="sqhC CDS" gene 1770266..1772164 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /label="sqhC gene" promotor_-10 complement(1771209..1771228) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1771217) /Source="Nicolas_upshifts" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1771242..1771251) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1772154..1772999 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /EC_number="1.15.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 20233928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Fe2+-dependent)" /protein_id="NP_389815.1" /db_xref="EnsemblGenomes-Gn:BSU19330" /db_xref="EnsemblGenomes-Tr:CAB13825" /db_xref="GOA:O35023" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="SubtiList:BG12676" /db_xref="UniProtKB/Swiss-Prot:O35023" /translation="MKRESYQAEMFNWCEALKDQIQKRGQLDQFEDQIDKMIEALEDD QTTEEDWYKQAAALYRDITESDDTSERRAYVPIGKHVLPKLPYKYSALEPYISRDIMI LHHTKHHQSYVDGLNKAESELKKARATKNYDLITHWERELAFHGAGHYLHSIFWFSMH PNGKRRPTGALFQMIDLSFGSYSAFKEHFTQASKKVEGVGWAILVWAPRSGRLEILTA EKHQLFSQWDVIPLLPLDVWEHAYYLQYKNDRASYVDHWWNVVDWREAEKRFEQAKEV VWKLY*" /label="sodF CDS" gene 1772154..1772999 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /label="sodF gene" S_feature 1773000..1774506 /Source="Nicolas_S_feature" /locus_tag="new_2104902_2106408" /HighExp="S5, S6, S4, S8, S3, S7, T5.0H, B36, BT, T4.0H" /AntisenseName="yocR" /AntisenseCor="-0.62866346519731298" /AntisenseRegPval="-30.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S745" CDS complement(1773032..1774369) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_389816.1" /db_xref="EnsemblGenomes-Gn:BSU19340" /db_xref="EnsemblGenomes-Tr:CAB13826" /db_xref="GOA:O34383" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13528" /db_xref="UniProtKB/Swiss-Prot:O34383" /translation="MKEANQWSSKLGFILAAAGSAIGLGAIWKFPYVAGTSGGGAFLL IFILFTVLIGLPLLLGEFIIGRRTQKDAVQSYKTLAPGTKWHWIGYLGMVTCFILLSF YSVVGGWILIYIIKGFTGGLSQTSGFDTIFASTISNPYLAVGGQLLFMVVTILVVAKG VSSGIEKASQVLMPALFLLFIILMVRSVTLDGAMEGIKFFLMPDLTAIDANTILYAMG QSFFLLSVGVSVMVTYSAYLEKQENLVQSAVSVTVMNMLVAVMAGIAIFPAVFSFGLK PDQGPVLLFNVLPTVFNQMPFGIIFLLAFLLLFLFAALTSAFSMLEILVAVLSKGDIN KRKRFAWLGGIAIFIVGVPSALSYGVLSDVTIFHLSIFDAADYLVSNILMPLGALLIS IFVPLKIPKQDLFDELKSGSNLKRKWFAVWLLLIRYLSPVAIIIVFLHVIGIF*" /label="yocR CDS" gene complement(1773032..1774369) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /label="yocR gene" downshifts complement(1773043) /Source="Nicolas_upshifts" /id="D1066" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="0.83968" /MaxDrop="2.44824" /score="27.8372036" /energy="-11.1" /TU="NA" /idTUdmin="U1580" /TUdmin=154 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1774397..1774416) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1774412) /Source="Nicolas_upshifts" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1774414..1775572) /Source="Nicolas_S_feature" /locus_tag="new_2106316_2107474_c" /HighExp="M9-stat, T1.30H, B60, T1.0H, T2.0H, T0.30H, T2.30H, T3.0H, T3.30H, Etha" /AntisenseName="yocS" /AntisenseCor="-6.3575129468026695E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S746" promotor_-35 complement(1774431..1774438) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1774490..1774493 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1774508..1774527 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1774508 /Source="Nicolas_upshifts" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="upshifts" CDS 1774588..1775553 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent symporter" /protein_id="NP_389817.1" /db_xref="EnsemblGenomes-Gn:BSU19350" /db_xref="EnsemblGenomes-Tr:CAB13827" /db_xref="GOA:O34524" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG13529" /db_xref="UniProtKB/Swiss-Prot:O34524" /translation="MDIIRKISHFAGQTFGIWVIVFAVLGFSFPSLFTWISSYITIFL GIIMFGMGLTLQADDFKELVRKPWQVIIGVIAQYTIMPLVAFGLAFGLHLPAEIAVGV ILVGCCPGGTASNVMTFLAKGNTALSVAVTTISTLLAPVVTPLLIMLFAKEWLPVSPG SLFISILQAVLFPIIAGLIVKMFFRKQVAKAVHALPLVSVIGIVAIVSAVVSGNRENL LQSGLLIFSVVILHNGIGYLLGFLCAKLLKMDYPSQKAIAIEVGMQNSGLGAALATAH FSPLSAVPSAIFSVWHNLSGSMLATYWSKKVKKKQAGSKSSNLSL*" /label="yocS CDS" gene 1774588..1775553 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /label="yocS gene" downshifts 1775541 /Source="Nicolas_upshifts" /id="D1067" /incds=0 /nref=42 /ntot=166 /MaxReadThrough="3.53218" /MaxDrop="5.09676" /score="30.279305" /energy="-16.4" /TU="U1581" /idTUdmin="U1581" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1775603..1776856) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /EC_number="2.3.1.61" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417, 22720735, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417, 22720735, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase complex (dihydrolipoamide transsuccinylase, E2 subunit)" /protein_id="NP_389818.2" /db_xref="EnsemblGenomes-Gn:BSU19360" /db_xref="EnsemblGenomes-Tr:CAB13828" /db_xref="GOA:P16263" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR006255" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10273" /db_xref="UniProtKB/Swiss-Prot:P16263" /translation="MAEIKVPELAESISEGTIAQWLKQPGDYVEQGEYLLELETDKVN VELTAEESGVLQEVLKDSGDTVQVGEIIGTISEGAGESSAPAPTEKTESKESVKEEKQ AEPAAQEVSEEAQSEAKSRTIASPSARKLAREKGIDLSQVPTGDPLGRVRKQDVEAYE KPASKPAPQQKQQPQAQKAQQSFDKPVEVQKMSRRRQTIAKRLVEVQQTSAMLTTFNE VDMTAVMNLRKRRKDQFFEQNEVKLGFMSFFTKAVVAALKKYPLLNAEIQGDELIVKK FYDIGIAVAADEGLVVPVVRDADRLTFAGIEKEIGELAKKARNNKLTLSELQGGSFTI TNGGTFGSLMSTPILNSPQVGILGMHKIQLRPVAIDEERFENRPMMYIALSYDHRIVD GKEAVGFLVTIKNLLEDPEQLLLEG*" /label="odhB CDS" gene complement(1775603..1776856) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /label="odhB gene" downshifts complement(1775617) /Source="Nicolas_upshifts" /id="D1068" /incds=0 /nref=200 /ntot=253 /MaxReadThrough="5.25481" /MaxDrop="7.42366" /score="11.7726103" /energy="-16.4" /TU="U1582" /idTUdmin="U1582" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" CDS complement(1776872..1779706) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /EC_number="1.2.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase (E1 subunit)" /protein_id="NP_389819.3" /db_xref="EnsemblGenomes-Gn:BSU19370" /db_xref="EnsemblGenomes-Tr:CAB13829" /db_xref="GOA:P23129" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR011603" /db_xref="InterPro:IPR023784" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR031717" /db_xref="InterPro:IPR032106" /db_xref="SubtiList:BG10272" /db_xref="UniProtKB/Swiss-Prot:P23129" /translation="MFQNSMKQRMNWEDFYGPNLGYALELYDQYTQDPNSIDPDLKEM FDELGAPPSDIKEASGTKEKGRVTADLIQKIASAVRLAEDIRTYGHLNASVNPLRKDE KKSELFPLSDYGLTEEEIKAIPASVICKDAPKNISNGLEAIQYLRNTYKRTISFEFDH VHDFKEREWLTRKIESGELFQKNSAEKLSAVLERLTEVEGFEQFLHRTFVGQKRFSIE GLDALVPVLDDIIAQSVKSGTTSVNIGMAHRGRLNVLAHVLGKPYEIIFSEFQHAPNK DLVPSEGSIGISYGWTGDVKYHLGANRELQDAETKSARITLANNPSHLEFINPIVEGS TRAAQETRTQSGYPVQDETKSLAILIHGDAAFPGEGIVAETLNLSSLKGYQVGGAIHI IANNMIGFTTESAESRSTKYASDLAKGYEIPIVHVNADDPEACLSAVKFAVEYRKTFN KDFLIDLIGYRRYGHNEMDEPSTTQPMLYDAVRKHPTVKQIFAEKLVKEGVVTEEVVQ NIEKSVTKRIEDAYQKVPSKKEHTACEIELPEPVSNGFPDVDTSIDFDVLRKLNGELI NWPESFNVFGKLKRILERRAKAFDDDRKVEWSLAESLAFASILKDGTPIRLTGQDSER GTFAQRNLVLHDSETGKEFVPLHHLSDCSTSFAVHNSPLSEGSVLGFEYGYNVHSPET LVLWEAQYGDFANAAQVYFDQFISAGRAKWGQKSGLVMLLPHGYEGQGPEHSSGRIER FLQLAAENNWTVANLTSAAQYFHILRRQAKMLLREEIRPLVIMTPKSLLRNPNTVSEV QELSESRFQPVYEQSGLSHDYEKVTRLVLSSGKVSIDISDHFNKLEDGKEWLHIARIE QLYPFPAKGVKELFAKLPNLKEIVWVQEEPQNMGAWGYISPYLTEIAPEGVSVQYIGR RRRSSPAEGDPTVHKKEQERIVSDSLTRKN*" /label="odhA CDS" gene complement(1776872..1779706) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /label="odhA gene" promotor_-10 complement(1779801..1779820) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1779816) /Source="Nicolas_upshifts" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1779818..1779934) /Source="Nicolas_S_feature" /locus_tag="new_2111720_2111836_c" /HighExp="dia15, G150, G135, H2O2, Lbexp, dia0, Oxctl, LBGtran, G180, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S747" promotor_-35 complement(1779835..1779842) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1779935..1781851) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23087684; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative activator of nitric oxide reductase" /protein_id="NP_389820.2" /db_xref="EnsemblGenomes-Gn:BSU19380" /db_xref="EnsemblGenomes-Tr:CAB13830" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG13567" /db_xref="UniProtKB/Swiss-Prot:O31849" /translation="MKFIKFNDSTIDSFLFMMLTDLAKTLTKSEAVEVEYGVQSYYNP FEKKIYMSHFWKDRAAEDMEAGLKSDVYLRSVGTRYSSLHEFANFLNDIHRHLTFKSF AKQLFMLLEDIRIEECIKRERPGTKHVFAKRKDMYRKHFSTQLTLNLERSIFTDALFC AIYFKLTAESPLETLPSMREDIDLMRPFIEQQLLRVYEADSTRQVLKIVEDLMDGLEE VLDKDMLNTYFFLPELDYAKAAEQPLFEEEKKAPKLSDDITLPKQSDGDEDIHEEEMP TWHRETEAPSKSFLQFDIEHGAKSDLGKDASREGDDGDQALGSVQGSARQTKRKDYSK LEALESQKDQPNGAGMADGKENKYAFPIYKEPQPATSEEELSYKQQAKTIESYQKRLK QMIQKTLEHKKTLPRTDLHAGRLNNKLLRYFTERNPRLFYKKQEPSSEIDAVFTLLVD CSASMFDKMDETKRGIVLFHEALKSVAVPHQIVGFWEDTNDATEKSQPNYFNTVIPFQ SSLRQDSGPAIMQLEPEEDNRDGYAIRQMTKKMLHRSEAQKFLIVFSDGEPAAFGYEQ NGIVDTSEAVIEARKRGIEVINVFLSNSEIEESQMKTIQDMYGKFSIFVPDVDQLPDV LYPLLKKLLHKSIG*" /label="yojO CDS" gene complement(1779935..1781851) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /label="yojO gene" CDS complement(1781862..1782776) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15491156, 23087684; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nitric-oxide reductase associated protein" /protein_id="NP_389821.1" /db_xref="EnsemblGenomes-Gn:BSU19390" /db_xref="EnsemblGenomes-Tr:CAB13831" /db_xref="GOA:O31850" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13566" /db_xref="UniProtKB/Swiss-Prot:O31850" /translation="MNRKGNLSMTTQLQHLTLPEDIQQKLLSYKEQPISPEFQSLIGT SGYEAEDEAILFDAIIALAMGKNVLLKGPTGSGKTKLAETLSSYFHKPMHSVNCSVDL DAEALVGYKTIENQSGQATIEFVSGPVTKAMKEGHFLYIDEINMAKPETLPILNGVLD YRKMMTNPFTGEVIRAKSGFGVIAAINEGYVGTVPLNEALKNRFVIIDVPYIKGELLK QVLMSQSALKDEKLIDRFITLSSDLIVQANNGQVSEEAASIRALIDTCDLAAYIPPRR AIERGIVEKLDDDREKAAVRNIAETLFE*" /label="yojN CDS" gene complement(1781862..1782776) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /label="yojN gene" promotor_-10 complement(1782780..1782799) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-10" upshifts complement(1782795) /Source="Nicolas_upshifts" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="upshifts" promotor_-35 complement(1782816..1782820) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-35" CDS complement(1782840..1783430) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /EC_number="1.15.1.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15897454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15897454; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="superoxide dismutase (exported lipoprotein)" /protein_id="NP_389822.1" /db_xref="EnsemblGenomes-Gn:BSU19400" /db_xref="EnsemblGenomes-Tr:CAB13832" /db_xref="GOA:O31851" /db_xref="InterPro:IPR001424" /db_xref="InterPro:IPR024134" /db_xref="InterPro:IPR036423" /db_xref="PDB:1S4I" /db_xref="PDB:1U3N" /db_xref="PDB:1XTL" /db_xref="PDB:1XTM" /db_xref="SubtiList:BG13565" /db_xref="UniProtKB/Swiss-Prot:O31851" /translation="MHRLLLLMMLTALGVAGCGQKKPPDPPNRVPEKKVVETSAFGHH VQLVNREGKAVGFIEIKESDDEGLDIHISANSLRPGASLGFHIYEKGSCVRPDFESAG GPFNPLNKEHGFNNPMGHHAGDLPNLEVGADGKVDVIMNAPDTSLKKGSKLNILDEDG SAFIIHEQADDYLTNPSGNSGARIVCGALLGNNEKQ*" /label="sodC CDS" gene complement(1782840..1783430) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /label="sodC gene" CDS complement(1783523..1784767) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /EC_number="3.5.1.-" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 22139507" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 22139507; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan hydrolase (cell wall-binding d,l-endopeptidase)" /protein_id="NP_389823.1" /db_xref="EnsemblGenomes-Gn:BSU19410" /db_xref="EnsemblGenomes-Tr:CAB13833" /db_xref="GOA:O31852" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13564" /db_xref="UniProtKB/Swiss-Prot:O31852" /translation="MKKKIVAGLAVSAVVGSSMAAAPAEAKTIKVKSGDSLWKLSRQY DTTISALKSENKLKSTVLYVGQSLKVPESSKKSTTSPSNSSKTSTYTVAYGDSLWMIA KNHKMSVSELKSLNSLSSDLIRPGQKLKIKGTSSSSGSNGSKKNSGSNSSGSSKSTYT VKLGDSLWKIANSLNMTVAELKTLNGLTSDTLYPKQVLKIKGSSSPKNGNSGSKKPSN SNPSKTTTYKVKAGDSLWKIANRLGVTVQSIRDKNNLSSDVLQIGQVLTISGASKSNP SNPTKPTKPKDNSGSNIQIGSKIDRMITEAKKYVGVPYRWGGNTPAGFDCSGFIYYLI NNVSSISRLSTAGYWNVMQKVSQPSVGDFVFFTTYKSGPSHMGIYLGGGDFIHASSSG VDISNLSNSYWKQRYLGARSYF*" /label="cwlS CDS" gene complement(1783523..1784767) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /label="cwlS gene" downshifts complement(1783525) /Source="Nicolas_upshifts" /id="D1069" /incds=0 /nref=20 /ntot=183 /MaxReadThrough="4.09529" /MaxDrop="3.77828" /score="11.0350171" /energy="-4.7" /TU="U1584,U1585" /idTUdmin="U1585" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1784830..1784848) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1784843) /Source="Nicolas_upshifts" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1784845..1785065) /Source="Nicolas_S_feature" /locus_tag="new_2116747_2116967_c" /HighExp="S2, Lbstat, T2.30H, M0t90, HiOs, T3.0H, Etha, M40t90, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S748" promotor_-35 complement(1784861..1784868) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1785051..1785069) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1785065) /Source="Nicolas_upshifts" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1785081..1785089) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1785149..1786366) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /EC_number="2.4.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative YDP-glycosyltransferase" /protein_id="NP_389824.2" /db_xref="EnsemblGenomes-Gn:BSU19420" /db_xref="EnsemblGenomes-Tr:CAB13834" /db_xref="GOA:O31853" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG13563" /db_xref="UniProtKB/Swiss-Prot:O31853" /translation="MANVLMIGFPGEGHINPSIGVMKELKSRGENITYYAVKEYKEKI TALDIEFREYHDFRGDYFGKNATGDEERDFTEMLCAFLKACKDIATHIYEEVKHESYD YVIYDHHLLAGKVIANMLKLPRFSLCTTFAMNEEFAKEMMGAYMKGSLEDSPHYESYQ QLAETLNADFQAEIKKPFDVFLADGDLTIVFTSRGFQPLAEQFGERYVFVGPSITERA GNNDFPFDQIDNENVLFISMGTIFNNQKQFFNQCLEVCKDFDGKVVLSIGKHIKTSEL NDIPENFIVRPYVPQLEILKRASLFVTHGGMNSTSEGLYFETPLVVIPMGGDQFVVAD QVEKVGAGKVIKKEELSESLLKETIQEVMNNRSYAEKAKEIGQSLKAAGGSKKAADSI LEAVKQKTQSANA*" /label="yojK CDS" gene complement(1785149..1786366) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /label="yojK gene" downshifts complement(1785175) /Source="Nicolas_upshifts" /id="D1070" /incds=0 /nref=14 /ntot=145 /MaxReadThrough="1.49168" /MaxDrop="4.07727" /score="9.41396656" /energy="-14.4" /TU="NA" /idTUdmin="U1586" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1786399..1786418) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1786407) /Source="Nicolas_upshifts" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1786432..1786439) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1786602..1787225) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /EC_number="2.7.7.85" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:21566650, 23192352, 24939848, 27252699, 27790204, 28751888" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21566650, 23192352, 24939848, 27252699, 27790204, 28751888; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore diadenylate cyclase" /protein_id="NP_389825.3" /db_xref="EnsemblGenomes-Gn:BSU19430" /db_xref="EnsemblGenomes-Tr:CAB13835" /db_xref="GOA:O31854" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR019457" /db_xref="InterPro:IPR034693" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG13562" /db_xref="UniProtKB/Swiss-Prot:O31854" /translation="MKAMRYEQISENAFKGKIQVYLEQILGDASLILKTLHEKDQCLL CELDDLGHVFQDMQGIASSFYLQSYIEEFTPAFIELAKAIKALSEHKHGALIVIERAD PVERFIQKGTSLHAEISSSLIESIFFPGNPLHDGALLVRENKLVSAANVLPLTTKEVD IHLGTRHRAALGMSGYTDALVLVVSEETGKMSFAKDGVLYPLISPRT*" /label="cdaS CDS" gene complement(1786602..1787225) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /label="cdaS gene" S_feature complement(1787226..1787376) /Source="Nicolas_S_feature" /locus_tag="new_2119128_2119278_c" /HighExp="S8, S5, S7, S6, Etha, S4, M9-stat, S3, C30, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S749" promotor_-35 1787252..1787258 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1787264 /Source="Nicolas_upshifts" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1787272..1787283 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1787290..1787298 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1787306..1787406 /Source="Nicolas_upshift_promotors" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 1787310..1787328 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1787321 /Source="Nicolas_upshifts" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1787359..1787377) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1787366..1787451 /Source="Nicolas_S_feature" /locus_tag="new_2119268_2119353" /HighExp="S8, S7, S4, S5, S6, BT, S3, T5.0H, S2, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigGF" /TUshortPSig="0.00699, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S750" upshifts 1787366 /Source="Nicolas_upshifts" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1787376) /Source="Nicolas_upshifts" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1787393..1787399) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1787427..1787434 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1787447..1787466 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1787453 /Source="Nicolas_upshifts" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="upshifts" CDS 1787491..1788849 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14766544, 15849754, 15855508, 16850406, 16954325, 17114254; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+-driven efflux MatE family protein" /protein_id="NP_389826.1" /db_xref="EnsemblGenomes-Gn:BSU19440" /db_xref="EnsemblGenomes-Tr:CAB13836" /db_xref="GOA:O31855" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13561" /db_xref="UniProtKB/Swiss-Prot:O31855" /translation="MKETQNAREKIKQLLHILIPIFITQAGLSLITFLDTVMSGKVSP ADLAGVAIGSSLWTPVYTGLAGILMAVTPIVAQLLGAEKKQKIPFTVLQAVYVAALLS IAVLVIGYAAVDLILGRLNLDIHVHQIAKHFLGFLSLGIFPLFVYTVLRSFIDSLGKT RVTMMITLSSLPINFVLNYVFIFGKFGMPALGGVGAGLASALTYWCICIISFFIIHKN APFSEYGIFLTMYKFSWKACKNLLKIGLPIGFAVFFETSIFAAVTLLMSHFHTVTIAS HQAAMNFASLLYMLPLSVSMALTIVVGFEAGAARFKDARSYSLIGIMMAIGFSLFTAA CILLFREQIAGMYTSDPDVLRLTQHFLIYALFFQLSDAVAAPIQGALRGYKDVNYTLA AAFVSYWVIGLPVGYMVGTFTSLGAFGYWIGLIAGLAAGAVGLFFRLAKLQKRYSQKQ HI*" /label="mdtK CDS" gene 1787491..1788849 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /label="mdtK gene" promotor_-10 complement(1787833..1787844) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1787838) /Source="Nicolas_upshifts" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1787858..1787864) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1788865..1789713 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665, 20935101, 22287516, 24599254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665, 20935101, 22287516, 24599254; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-antagonist of RsbT; component of the anxiosome (stressosome)" /protein_id="NP_389827.1" /db_xref="EnsemblGenomes-Gn:BSU19450" /db_xref="EnsemblGenomes-Tr:CAB13837" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG13560" /db_xref="UniProtKB/Swiss-Prot:O31856" /translation="MAKNKKLFEYLSQHAETISSTWYETIEETDPNSIYASTDPVVIH NLKSQNLAFNYKINRIFIDDEDVYLPILKEWAFEVTQDQEHLKTPIHYIIREFVRVRD LYVSYVKEFVHLNQNTVKSEEAEDLYHALIKAFDLVIHIFIEEMYKNTSLQLQAQKDM ITELSAPVIVLFHSVGLLPLIGDIDTVRAKLIMENTLHQCAKKKVTQLYIDLSGVAVI DTMVAHQLFSLIEALRLIGVSSTLSGIRPEIAQTAVQLGLSFEGISLRSTLASAIASD LKLKKV*" /label="rsbRC CDS" gene 1788865..1789713 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /label="rsbRC gene" promotor_-10 complement(1789129..1789148) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1789136) /Source="Nicolas_upshifts" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1789162..1789170) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1789676 /Source="Nicolas_upshifts" /id="D1071" /incds=0 /nref=10 /ntot=138 /MaxReadThrough="1.62054" /MaxDrop="3.13267" /score="12.3887642" /energy="-14" /TU="NA" /idTUdmin="U1591" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1789708) /Source="Nicolas_upshifts" /id="D1072" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="1.55562" /MaxDrop="4.60101" /score="23.8391861" /energy="-13.7" /TU="NA" /idTUdmin="U1594" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1789739..1790404) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /EC_number="3.5.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15136574, 20308541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15136574, 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate N-acetylglucosamine deacetylase (second enzyme)" /protein_id="YP_054582.2" /db_xref="EnsemblGenomes-Gn:BSU19460" /db_xref="EnsemblGenomes-Tr:CAB13838" /db_xref="GOA:O31857" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023841" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG13559" /db_xref="UniProtKB/Swiss-Prot:O31857" /translation="MKEHVLVILPHPDDESYGVAGLIALNRKKDIPVTYACATLGEMG RNMGDPFFANRETLPLLRKQELINACKEMDINDLRMLGLRDKTLEFEDDEYLADIMEE IIDDVKPSLIVTFYPGHGVHPDHDACGEAVIRALYRKKKEDRPRTICMAITRNREEVL GEADVVLDIKEVADIKMNALRAHRTQTEGMLRELEEKLKNNEPVMATWFEEEIYWTYQ WND*" /label="bshBB CDS" gene complement(1789739..1790404) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /label="bshBB gene" downshifts complement(1789753) /Source="Nicolas_upshifts" /id="D1073" /incds=0 /nref=189 /ntot=251 /MaxReadThrough="3.68743" /MaxDrop="7.13247" /score="23.8391861" /energy="-13.7" /TU="U1594" /idTUdmin="U1596" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1790423..1790773) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (bacillithiol synthesis operon)" /protein_id="NP_389829.1" /db_xref="EnsemblGenomes-Gn:BSU19470" /db_xref="EnsemblGenomes-Tr:CAB13839" /db_xref="InterPro:IPR014934" /db_xref="InterPro:IPR036492" /db_xref="PDB:1NJH" /db_xref="SubtiList:BG13558" /db_xref="UniProtKB/Swiss-Prot:O31858" /translation="MKAIIKEDVQASLERYADRPVYIHLETTTGSYSAHLNEKNMTVV AYIRNAKVTYHQAKIKGNGPYRVGLKTEEGWIYAEGLTEYTVDEENRLLMAGHLPGGK LAISLQISEKPFTV*" /label="yojF CDS" gene complement(1790423..1790773) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /label="yojF gene" CDS complement(1790770..1791048) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097741.1" /db_xref="EnsemblGenomes-Gn:BSU19479" /db_xref="EnsemblGenomes-Tr:CAX52638" /db_xref="UniProtKB/Swiss-Prot:O68260" /translation="MDNDKEIVKAYASLWNNRSLAHDDAEAVAEAIDLELLDKRTHPR LRKPMLEKYFAAIQRIVNSQLEPAVKYQLVKLHTERAEYLKEERGEQS*" /label="yoyC CDS" gene complement(1790770..1791048) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /label="yoyC gene" promotor_-10 complement(1791075..1791094) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1791091) /Source="Nicolas_upshifts" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1791109..1791115) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1791124..1792020) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636, 23944997; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative N-acetylated toxic metabolites" /protein_id="NP_389830.2" /db_xref="EnsemblGenomes-Gn:BSU19480" /db_xref="EnsemblGenomes-Tr:CAB13840" /db_xref="GOA:O31859" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004626" /db_xref="SubtiList:BG13557" /db_xref="UniProtKB/Swiss-Prot:O31859" /translation="MQHAETKKGVIYTAVSFIMWGLFPLYWKLLEQLPALDILAHRII WSFVFMCIVLFFLRQWKIGWQELRSLKKNGGILSLFLASILISINWFVYIWAVNHGFL LEASLGYYINPLVSVLLGILFLKEKLNRLQLVAVSIAAAGVIISAFQYGSIPYVALLL AFSFGLYGLSKKRTSLPSAIGLTLETFMIMPIALGYLLFSGHVQPAGAESGGTWLLLF LAGVFTALPLLLFAEGAKRLPLYQVGILQYIAPTITLLIGLFVYHEPFSSSKAFTFSC IWAALLLFTFSQVKWKRASKSH*" /label="yojE CDS" gene complement(1791124..1792020) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /label="yojE gene" promotor_-35 1791862..1791871 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1791882 /Source="Nicolas_upshifts" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1791885..1791904 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1791900..1792118 /Source="Nicolas_S_feature" /locus_tag="new_2123802_2124020" /HighExp="S6, S8, S7, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="yojE" /AntisenseCor="-0.562105310907978" /AntisenseRegPval="-23.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S751" promotor_-10 complement(1792044..1792063) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1792064) /Source="Nicolas_upshifts" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1792075..1792082) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1792119..1792592 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17720779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17720779; Product type s: structure" /codon_start=1 /transl_table=11 /product="component of the spore coat" /protein_id="YP_054583.1" /db_xref="EnsemblGenomes-Gn:BSU19490" /db_xref="EnsemblGenomes-Tr:CAE01457" /db_xref="GOA:Q7WY67" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG14190" /db_xref="UniProtKB/Swiss-Prot:Q7WY67" /translation="MFEWNKYFPFHNQFSKEALKKADPKEVETYVNRVMESVFGSDYA AQFPFRDPLPQKEHPAKPDAKPDVKPDIDIFETADHVFVKVPISEEWLEQVRIKHTSH ELWLENLPRADHPKKVNLPCLVKRKGTKAVYKDGLLEVMFQKQQDYNMSEVEIIR*" /label="gerT CDS" gene 1792119..1792592 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /label="gerT gene" downshifts 1792589 /Source="Nicolas_upshifts" /id="D1074" /incds=0 /nref=23 /ntot=53 /MaxReadThrough="-0.0703700000000005" /MaxDrop="9.27889" /score="40.8456275" /energy="-16.6" /TU="NA" /idTUdmin="U1595" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1792627..1792863) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389832.1" /db_xref="EnsemblGenomes-Gn:BSU19510" /db_xref="EnsemblGenomes-Tr:CAB13842" /db_xref="GOA:O31861" /db_xref="SubtiList:BG13555" /db_xref="UniProtKB/Swiss-Prot:O31861" /translation="MYPHHSYLRGIPGPAGYPARSPFLFGAPLVGGLLGGFLGSALFN YSRPYAYPPGPYGYGGGPYGFGAGVPYGGYPGFY*" /label="yojB CDS" gene complement(1792627..1792863) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /label="yojB gene" downshifts complement(1792635) /Source="Nicolas_upshifts" /id="D1075" /incds=0 /nref=37 /ntot=68 /MaxReadThrough="2.10188" /MaxDrop="7.8003" /score="35.4403926" /energy="-16.6" /TU="NA" /idTUdmin="U1597" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1792886..1792905) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1792901) /Source="Nicolas_upshifts" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1792919..1792928) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1792948..1794282) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 3020045, 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/anion permease" /protein_id="NP_389833.1" /db_xref="EnsemblGenomes-Gn:BSU19520" /db_xref="EnsemblGenomes-Tr:CAB13843" /db_xref="GOA:O31862" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG13554" /db_xref="UniProtKB/Swiss-Prot:O31862" /translation="MPILIVAVGVLILLFLIIKVKLNTFVSLIVVSFLVAIGLGMDIN KIVLSIETGIGGQLGHLALVFGLGAMLGRLVSDAGGGYRIAITLIDKFGRKRIQAAVV VASFIIGIALFFEVGLVLLIPIVYAIAKELKMPFLYLGIPMAAALNVTHGFLPPHPAP TAISVAYGAHIGQVLLFGIIIAVPTTVIAGPLFNKFAMKRFPGAYQKHGNLSGLGPRK EFQLDETPGFAISAVTSLFPVIFMAMATIFSLLLSEHSKGKDIIEFIGTPGTAMLISL LLALYTMGYARKISMQEIGRSISESISQIAMMLLIIGGGGAFKQVLIDGGVGDYVADF FRQTNMSPLFVAWTIAAVLRLCLGSATVAALTTAGMAAPLMEAGSVNPALMVLATGAG SVIACHVNDAGFWMVKEFFGLSMKETFQTWTLLTTVLSVTGLGCVLLAGLVM*" /label="yojA CDS" gene complement(1792948..1794282) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /label="yojA gene" S_feature complement(1794283..1794418) /Source="Nicolas_S_feature" /locus_tag="new_2126185_2126320_c" /HighExp="M0t90, M40t90, Lbtran, S1, dia5, Mt0, T0.0H, BI, Lbstat, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25781100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S752" promotor_-10 complement(1794415..1794434) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1794425) /Source="Nicolas_upshifts" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1794449..1794456) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1794514..1794521 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1794536..1794555 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1794539 /Source="Nicolas_upshifts" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1794540..1794646 /Source="Nicolas_S_feature" /locus_tag="new_2126442_2126548" /HighExp="M0t90, M40t90, LoTm, Salt, Cold, BI, HPh, LBGstat, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S753" CDS 1794647..1795036 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /EC_number="5.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_389834.1" /db_xref="EnsemblGenomes-Gn:BSU19530" /db_xref="EnsemblGenomes-Tr:CAB13844" /db_xref="GOA:O34882" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG13530" /db_xref="UniProtKB/Swiss-Prot:O34882" /translation="MPLLRFDVIEGRDEKSLQLLLDTAHQAMVEAFGVPERDRYQIVH QHPANELIIQDAGLGFQRTKDMVIISMTSKARTESQKEKLYALLAERLEKKCEISPDD LMVSITENGDADWSFGLGEAQFLNGKL*" /label="yodA CDS" gene 1794647..1795036 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /label="yodA gene" downshifts 1795046 /Source="Nicolas_upshifts" /id="D1076" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.20831" /MaxDrop="2.65754" /score="14.4455719" /energy="-13.2" /TU="NA" /idTUdmin="U1599" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1795443..1795781) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17158660, 18208493, 20652907, 27531959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17158660, 18208493, 20652907, 27531959; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_389835.1" /db_xref="EnsemblGenomes-Gn:BSU19540" /db_xref="EnsemblGenomes-Tr:CAB13845" /db_xref="GOA:O34844" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:5HS7" /db_xref="PDB:5HS8" /db_xref="PDB:5HS9" /db_xref="SubtiList:BG13531" /db_xref="UniProtKB/Swiss-Prot:O34844" /translation="MGNTMCPKMESAFSLLGKRWNGLIIHVLMDGPKRFKEITETIPM ISQKMLAERLKELEQNEIVERQVLPETPVKVIYTLTEKGTALQAVFQEMQAWADQFCE PGDTVCEEEK*" /label="arxR CDS" gene complement(1795443..1795781) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /label="arxR gene" promotor_-35 1795804..1795811 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1795825..1795844 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1795834 /Source="Nicolas_upshifts" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="upshifts" S_feature 1795838..1795910 /Source="Nicolas_S_feature" /locus_tag="new_2127740_2127812" /HighExp="dia5, Diami, dia15, Salt, Lbtran, Heat, HiOs, S1, aero, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S754" promotor_-10 complement(1795869..1795888) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1795872) /Source="Nicolas_upshifts" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1795900..1795906) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1795911..1796519 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /EC_number="1.6.99.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 21749987, 24525333, 26312069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="water forming NADH oxidase (nitroreductase)" /protein_id="NP_389836.1" /db_xref="EnsemblGenomes-Gn:BSU19550" /db_xref="EnsemblGenomes-Tr:CAB13846" /db_xref="GOA:P81102" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG13532" /db_xref="UniProtKB/Swiss-Prot:P81102" /translation="MTNTLDVLKARASVKEYDTNAPISKEELTELLDLATKAPSAWNL QHWHFTVFHSDESKAELLPVAYNQKQIVESSAVVAILGDLKANENGEEVYAELASQGY ITDEIKQTLLGQINGAYQSEQFARDSAFLNASLAAMQLMIAAKAKGYDTCAIGGFNKE QFQKQFDISERYVPVMLISIGKAVKPAHQSNRLPLSKVSTWL*" /label="noxC CDS" gene 1795911..1796519 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /label="noxC gene" downshifts 1796509 /Source="Nicolas_upshifts" /id="D1077" /incds=0 /nref=98 /ntot=245 /MaxReadThrough="1.58009" /MaxDrop="5.56809" /score="28.8840715" /energy="-14.3" /TU="NA" /idTUdmin="U1600" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1796562..1797164) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389837.1" /db_xref="EnsemblGenomes-Gn:BSU19560" /db_xref="EnsemblGenomes-Tr:CAB13847" /db_xref="GOA:O34842" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13533" /db_xref="UniProtKB/Swiss-Prot:O34842" /translation="MKHIYEKGTSDNVLLLLHGTGGNEHDLLSLGRFIDPDAHLLGVR GSVLENGMPRFFKRLSEGVFDEKDLVVRTRELKDFIDEAAETHQFNRGRVIAVGYSNG ANIAASLLFHYKDVLKGAILHHPMVPIRGIELPDMAGLPVFIGAGKYDPLCTKEESEE LYRYLRDSGASASVYWQDGGHQLTQHEAEQAREWYKEAIV*" /label="yodD CDS" gene complement(1796562..1797164) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /label="yodD gene" CDS complement(1797180..1798091) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 17407181, 19329649, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-dependent lyase/dioxygenase" /protein_id="NP_389838.1" /db_xref="EnsemblGenomes-Gn:BSU19570" /db_xref="EnsemblGenomes-Tr:CAB13848" /db_xref="GOA:O34543" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13534" /db_xref="UniProtKB/Swiss-Prot:O34543" /translation="MKTEGLHHVTAFARDPQENLRFYTEVLGLRLVKKTVNFDDPGTY HFYFGNQNGDPGTIMTFFPFQGSGQGTVGKGQAGRVYFSVPSGSLSFWKERLEKSGLS LEEKTLFGEKGLIFDDTEDLPLAIMEDAKSGKSEWTPDGITTNEAITGMKGVLLYSYD PQATIQLLTESFGYTKVAEEDQIVRLASSAAVGGVIDVHLHPEKRGVGGYGTVHHVAF RTKKKEQAKWLPIIAENHLPSSEILDREYFTSVYFREKGGILFEIATDEPGFMTDETF AELGTSLKLPEWLEKHRQQITDILPEL*" /label="yodE CDS" gene complement(1797180..1798091) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /label="yodE gene" promotor_-10 complement(1798120..1798139) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1798136) /Source="Nicolas_upshifts" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1798155..1798160) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1798212..1798215 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1798230..1798249 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1798232 /Source="Nicolas_upshifts" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="upshifts" CDS 1798275..1798475 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016, 24843172; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="YP_003097742.1" /db_xref="EnsemblGenomes-Gn:BSU19579" /db_xref="EnsemblGenomes-Tr:CAX52639" /db_xref="GOA:C0H431" /db_xref="InterPro:IPR021741" /db_xref="UniProtKB/Swiss-Prot:C0H431" /translation="MVKKALIVILILLPFVQLALLPLVNRIEPIMFGLPFFHFWLLLW IIVTPLCSFGIYQMQKKDGGLE*" /label="yoyD CDS" gene 1798275..1798475 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /label="yoyD gene" CDS 1798475..1799965 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12823818, 15849754, 16850406, 24142252, 27766092; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite permease" /protein_id="NP_389839.1" /db_xref="EnsemblGenomes-Gn:BSU19580" /db_xref="EnsemblGenomes-Tr:CAB13849" /db_xref="GOA:O34745" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13535" /db_xref="UniProtKB/Swiss-Prot:O34745" /translation="MQGNLTALLITAIIVLTVVCIGFLAGRDKSSRTSVEEWSVGGRR FGGLLVWFLVGADLYTAYTFLGLTSTAFTGGSVAFFAIPYSVLAYFIAYFFLPKLWKV AKIHKLTTLADYARERFNSKLLASLVAIVGVLMLIPYICLQLSGIQDTLQVAGTGYIN VKFVVIISFILVALYTFFSGIKGPTYTAIIKDILVWVIMLFMVVSLPLIHFNGWTPMI DTLVKEAPQMLTIPSEGPKGIPWFITASIVSALALFMWAHAATGVFTAKSADAVRKNS MFLPLYNIVLILVIFLGFIAFLVLPEDTNPRLALLHLIQTSYGGVAQGFAYATIALAS LIPCSIMAIGASNLFANNLYRDLIHPNVSQSKLTLVTRSMVFVVIGLALLFGMLFPTA LVTLQLLGVSGMVQIFPAIAVSLFWKNQTKEATVIGLLAGLAVTFIVYITQSAHGIYE GFWGLAANMIAVVILNPLFVKNAGSNPVIEGLFGKKQDANPNQKGA*" /label="yodF CDS" gene 1798475..1799965 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /label="yodF gene" promotor_-10 complement(1799210..1799221) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1799214) /Source="Nicolas_upshifts" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1799235..1799241) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1799953 /Source="Nicolas_upshifts" /id="D1078" /incds=0 /nref=128 /ntot=189 /MaxReadThrough="1.75716" /MaxDrop="6.37839" /score="42.3111155" /energy="-14.6" /TU="NA" /idTUdmin="U1603" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1800000..1801400) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /EC_number="3.4.21.102" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8996100, 10974125, 14526016, 17114254, 19889088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxy-terminal processing protease (Prc homolog, tail specific protease)" /protein_id="NP_389840.1" /db_xref="EnsemblGenomes-Gn:BSU19590" /db_xref="EnsemblGenomes-Tr:CAB13850" /db_xref="GOA:O34666" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11794" /db_xref="UniProtKB/Swiss-Prot:O34666" /translation="MKRQLKLFFIVLITAVVASALTLFITGNSSILGQKSASTGDSKF DKLNKAYEQIKSDYYQKTDDDKLVDGAIKGMIQSLDDPYSTYMDQEQAKSFDETISAS FEGIGAQVEEKDGEILIVSPIKGSPAEKAGIKPRDQIIKVNGKSVKGMNVNEAVALIR GKKGTKVKLELNRAGVGNIDLSIKRDTIPVETVYSEMKDNNIGEIQITSFSETTAKEL TDAIDSLEKKGAKGYILDLRGNPGGLMEQAITMSNLFIDKGKNIMQVEYKNGSKEVMK AEKERKVTKPTVVLVNDGTASAAEIMAAALHESSNVPLIGETTFGKGTVQTAKEYDDG STVKLTVAKWLTADGEWIHKKGIKPQVKAELPDYAKLPYLDADKTYKSGDTGTNVKVA QKMLKALGYKVKVNSMYDQDFVSVVKQFQKKEKLNETGILTGDTTTKLMIELQKKLSD NDTQMEKAIETLKKEM*" /label="ctpA CDS" gene complement(1800000..1801400) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /label="ctpA gene" downshifts complement(1800024) /Source="Nicolas_upshifts" /id="D1079" /incds=0 /nref=188 /ntot=292 /MaxReadThrough="0.590400000000001" /MaxDrop="7.62713" /score="34.5981085" /energy="-14.6" /TU="NA" /idTUdmin="U1606" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-35 1801171..1801180 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1801192..1801207 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1801206 /Source="Nicolas_upshifts" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1801420..1801439) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1801440) /Source="Nicolas_upshifts" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1801453..1801460) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1801499..1801508 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1801514 /Source="Nicolas_upshifts" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1801521..1801540 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1801553..1802254 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19703276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_389841.1" /db_xref="EnsemblGenomes-Gn:BSU19600" /db_xref="EnsemblGenomes-Tr:CAB13851" /db_xref="GOA:O34954" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13536" /db_xref="UniProtKB/Swiss-Prot:O34954" /translation="MSRYLEMLSLFGVAGAHPGGLAFSKAVLQKAAPSPDQPILDAGC GTGQTAAYLGHLLYPVTVVDKDPIMLEKAKKRFANEGLAIPAYQAELEHLPFSSESFS CVLSESVLSFSRLTSSLQEISRVLKPSGMLIGIEAALKKPMPPAEKKQMMDFYGFTCL HEESEWHKLLRSYGFQKTEAMSLLPEDMEFEPTTEMDLSQTIDPIYYDTLQTHYQLMQ LYSEYMGHCIFIAYK*" /label="yodH CDS" gene 1801553..1802254 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /label="yodH gene" promotor_-35 1802279..1802287 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1802301..1802320 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1802306 /Source="Nicolas_upshifts" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="upshifts" CDS 1802342..1802593 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546, 23155385; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389842.1" /db_xref="EnsemblGenomes-Gn:BSU19610" /db_xref="EnsemblGenomes-Tr:CAB13852" /db_xref="GOA:O34654" /db_xref="SubtiList:BG13537" /db_xref="UniProtKB/Swiss-Prot:O34654" /translation="MERYYHLCKNHQGKVVRITERGGRVHVGRITRVTRDRVFIAPVG GGPRGFGYGYWGGYWGYGAAYGISLGLIAGVALAGLFFW*" /label="yodI CDS" gene 1802342..1802593 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /label="yodI gene" downshifts 1802614 /Source="Nicolas_upshifts" /id="D1080" /incds=0 /nref=49 /ntot=83 /MaxReadThrough="0.88268" /MaxDrop="7.18785" /score="13.9812819" /energy="-15.5" /TU="NA" /idTUdmin="U1607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1802664..1803485) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /EC_number="3.4.16.4" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8631706, 15187182, 24909784" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8631706, 15187182, 24909784; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase lipoprotein (D-ala releasing from tetrapeptide hydrolysis)" /protein_id="NP_389843.1" /db_xref="EnsemblGenomes-Gn:BSU19620" /db_xref="EnsemblGenomes-Tr:CAB13853" /db_xref="GOA:O34866" /db_xref="InterPro:IPR003709" /db_xref="InterPro:IPR009045" /db_xref="PDB:4OX3" /db_xref="SubtiList:BG13538" /db_xref="UniProtKB/Swiss-Prot:O34866" /translation="MKKSGKWFSLAAALSVTAIVGAGCSMSNGDAQKDTKTTAETKQT EQKTADSKKSNTQNSEFSLESQYFNDIKKVDGLETIQNPENILALVNKQYALPGNYEP SDLVIPDVEFSFEEKIQKRYIRKEAADALKTMFDAAKKEGYELAAVSGYRSYDRQKVI FDNEVSLKGERKAKEAVAYPGESEHQTGLAMDISSRSNGFELNEAFGSTADGKWVQDN AYKYGFIIRYPKNKEDITKYEYEPWHLRYVGKKAAKVIQDNDLTLEEYFEKVKKI*" /label="ldcB CDS" gene complement(1802664..1803485) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /label="ldcB gene" downshifts complement(1802690) /Source="Nicolas_upshifts" /id="D1081" /incds=0 /nref=180 /ntot=242 /MaxReadThrough="0.784690000000001" /MaxDrop="5.88637" /score="-9.13236272" /energy="-6.1" /TU="NA" /idTUdmin="U1609" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1803486..1803567) /Source="Nicolas_S_feature" /locus_tag="new_2135388_2135469_c" /HighExp="dia15, LBGexp, G180, LBGtran, dia0, H2O2, Oxctl, Lbexp, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S755" CDS complement(1803568..1804269) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12571059, 16511068, 21279421, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12571059, 16511068, 21279421, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_389844.1" /db_xref="EnsemblGenomes-Gn:BSU19630" /db_xref="EnsemblGenomes-Tr:CAB13854" /db_xref="GOA:O34925" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR004402" /db_xref="InterPro:IPR018016" /db_xref="InterPro:IPR035994" /db_xref="PDB:4D8V" /db_xref="PDB:4D8X" /db_xref="PDB:4D8Y" /db_xref="PDB:4D98" /db_xref="PDB:4D9H" /db_xref="PDB:4DA0" /db_xref="PDB:4DA6" /db_xref="PDB:4DA7" /db_xref="PDB:4DA8" /db_xref="PDB:4DAB" /db_xref="PDB:4DAE" /db_xref="PDB:4DAN" /db_xref="PDB:4DAO" /db_xref="PDB:4DAR" /db_xref="SubtiList:BG12581" /db_xref="UniProtKB/Swiss-Prot:O34925" /translation="MSVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRG MYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRD VILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFY NDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQT TFHDMIEVALHSVSQ*" /label="deoD CDS" gene complement(1803568..1804269) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /label="deoD gene" S_feature complement(1804270..1804359) /Source="Nicolas_S_feature" /locus_tag="new_2136172_2136261_c" /HighExp="dia15, G180, dia5, LBGtran, dia0, LBGexp, Lbexp, G150, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S756" promotor_-10 complement(1804344..1804363) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1804359) /Source="Nicolas_upshifts" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1804379..1804383) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1804417..1804423 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1804438..1804449 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1804455 /Source="Nicolas_upshifts" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="upshifts" CDS 1804471..1804596 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24079885" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097743.1" /db_xref="EnsemblGenomes-Gn:BSU19639" /db_xref="EnsemblGenomes-Tr:CAX52640" /db_xref="UniProtKB/Swiss-Prot:C0H432" /translation="MGKKHRNRITGQKKNNHIPEKDIIAAEEAHGKEYSAAKRKP*" /label="yoyE CDS" gene 1804471..1804596 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /label="yoyE gene" downshifts 1804594 /Source="Nicolas_upshifts" /id="D1082" /incds=0 /nref=9 /ntot=26 /MaxReadThrough="0.67198" /MaxDrop="4.89617" /score="16.4028635" /energy="-8.5" /TU="NA" /idTUdmin="U1610" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1804636..1804950) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24079885, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24079885, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="shape determination factor" /protein_id="NP_389845.2" /db_xref="EnsemblGenomes-Gn:BSU19640" /db_xref="EnsemblGenomes-Tr:CAB13855" /db_xref="InterPro:IPR025923" /db_xref="SubtiList:BG13539" /db_xref="UniProtKB/Swiss-Prot:O30472" /translation="MMLSVFKKKSCSYDVTIFQTPRFGEKKGYRAVYRTELNGSDHQD VLKRAFSLFNVFDTVPSDYDARFMATGDVILIDEGRKGKTYYQLLPAGWRKINRLIVQ TT*" /label="yodL CDS" gene complement(1804636..1804950) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /label="yodL gene" downshifts complement(1804648) /Source="Nicolas_upshifts" /id="D1083" /incds=0 /nref=96 /ntot=232 /MaxReadThrough="1.74792" /MaxDrop="5.79235" /score="-0.334745097" /energy="-8.5" /TU="NA" /idTUdmin="U1611" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1804971..1804989) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1804978) /Source="Nicolas_upshifts" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1805000..1805008) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1805011..1805622) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /EC_number="3.1.3.27" /EC_number="3.1.3.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27528508, 28168443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27528508, 28168443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol phosphate (PGP) phosphatase; undecaprenyl-pyrophosphate phosphatase (promiscuous activity)" /protein_id="NP_389846.1" /db_xref="EnsemblGenomes-Gn:BSU19650" /db_xref="EnsemblGenomes-Tr:CAB13856" /db_xref="GOA:O34349" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR036938" /db_xref="PDB:5JKI" /db_xref="SubtiList:BG13540" /db_xref="UniProtKB/Swiss-Prot:O34349" /translation="MYKPVSLFLFFLILAAAIHTNAVQSADEAISKAAVLIRQPWLNE VMTGITHLGASSFLLPLIVIIGAGMFFYRKTWDGLLMLLVFGTDRLLNKVLKEWIERV RPDFAPLVHESSFSFPSGHSMNAACVYPVIAYFLVKHLPFLSKHKKMVYIIAGVIAVL VGISRVYLGVHFVTDVLGGFSLGLLLFFLVKGFDEKIKRFRQK*" /label="pgpB CDS" gene complement(1805011..1805622) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /label="pgpB gene" CDS complement(1805700..1805876) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389847.1" /db_xref="EnsemblGenomes-Gn:BSU19660" /db_xref="EnsemblGenomes-Tr:CAB13857" /db_xref="InterPro:IPR025545" /db_xref="SubtiList:BG13751" /db_xref="UniProtKB/Swiss-Prot:O31863" /translation="MKEIDLVIDTEEIAEFFYRELARRGYIPSEDELFEIADITFDYL IEKCMIDEELDEDE*" /label="yozD CDS" gene complement(1805700..1805876) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /label="yozD gene" downshifts complement(1805704) /Source="Nicolas_upshifts" /id="D1084" /incds=0 /nref=35 /ntot=48 /MaxReadThrough="3.33111" /MaxDrop="5.99901" /score="19.8458751" /energy="-11.9" /TU="U1612,U1613" /idTUdmin="U1615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1805715) /Source="Nicolas_upshifts" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1805719..1805738) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1805754..1805757) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1805890..1805908) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-10" upshifts complement(1805911) /Source="Nicolas_upshifts" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="upshifts" S_feature complement(1805913..1806134) /Source="Nicolas_S_feature" /locus_tag="new_2137815_2138036_c" /HighExp="S8, S7, S6, BT, B36, Pyr, G/S, H2O2, S5, G135" /AntisenseName="yoyF" /AntisenseCor="0.43167183745996701" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S757" promotor_-35 complement(1805924..1805929) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-35" promotor_-35 1805934..1805939 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1805954..1805972 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1805956 /Source="Nicolas_upshifts" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="upshifts" CDS 1805995..1806138 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097744.1" /db_xref="EnsemblGenomes-Gn:BSU19669" /db_xref="EnsemblGenomes-Tr:CAX52641" /db_xref="GOA:C0H433" /db_xref="UniProtKB/Swiss-Prot:C0H433" /translation="MIAKMMEALDGERFDIIMEKTLKGMTRVMIWGCLPYFLYVLIRM FTN*" /label="yoyF CDS" gene 1805995..1806138 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /label="yoyF gene" CDS complement(1806135..1806815) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389848.1" /db_xref="EnsemblGenomes-Gn:BSU19670" /db_xref="EnsemblGenomes-Tr:CAB13858" /db_xref="SubtiList:BG13541" /db_xref="UniProtKB/Swiss-Prot:O34414" /translation="MKQNKPKFQVGDIVVVIMYGTVGTITKVHQIDKHYLYEVNHNEV LYFESSIQLYKDYEGVIVDMEKLDIEYEFLIGDVVYVKDYGKELFRIIGHRTEIWRYL EDGWEDIIYELTRLKDGEWLETEEEDLTLVLRKYEMDQFVHQLLFVHYVGETGHEIGE DIASSALLQFEGGDEDQDTLHILAVSIVDELLDIYNDYKILYEMFQDEEYKDMMMFVL ESLKEHFS*" /label="yodN CDS" gene complement(1806135..1806815) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /label="yodN gene" S_feature 1806139..1807150 /Source="Nicolas_S_feature" /locus_tag="new_2138041_2139052" /HighExp="LoTm, S3, S8, S7, S4, T5.0H, BT, T4.0H, Pyr, S6" /AntisenseName="yodN" /AntisenseCor="0.52628108909126403" /AntisenseRegPval="-19.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S758" promotor_-10 complement(1806842..1806861) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1806848) /Source="Nicolas_upshifts" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1806875..1806884) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1806966..1807190) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389849.1" /db_xref="EnsemblGenomes-Gn:BSU19680" /db_xref="EnsemblGenomes-Tr:CAB13859" /db_xref="InterPro:IPR010673" /db_xref="InterPro:IPR023089" /db_xref="InterPro:IPR036806" /db_xref="PDB:2FJ6" /db_xref="SubtiList:BG13752" /db_xref="UniProtKB/Swiss-Prot:O31864" /translation="MKSFYHYLLKYRHPKPKDSISEFANQAYEDHSFPKTSTDYHEIS SYLELNADYLHTMATFDEAWDQYESEVHGR*" /label="yozE CDS" gene complement(1806966..1807190) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /label="yozE gene" downshifts complement(1806980) /Source="Nicolas_upshifts" /id="D1085" /incds=0 /nref=115 /ntot=243 /MaxReadThrough="1.81033" /MaxDrop="7.07662" /score="34.0666929" /energy="-10.8" /TU="NA" /idTUdmin="U1616" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1807231..1807250) /Source="Nicolas_upshift_promotors" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1807243) /Source="Nicolas_upshifts" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1807277..1807555) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344, 24914178" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097745.1" /db_xref="EnsemblGenomes-Gn:BSU19689" /db_xref="EnsemblGenomes-Tr:CAX52642" /db_xref="InterPro:IPR022451" /db_xref="InterPro:IPR022453" /db_xref="UniProtKB/Swiss-Prot:C0H434" /translation="MKTCEWCGELEAVPGRNTVYWELPDGTRAIELTDTPAMVCSSCG MTYQEENTVKEIEDQLLLIQTKKLPESLTYQQLMETERILKRNYFDFS*" /label="yokU CDS" gene complement(1807277..1807555) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /label="yokU gene" CDS complement(1807552..1808967) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /EC_number="5.4.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10629195, 10839984, 11148055, 17254853, 18307109, 21538109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629195, 10839984, 11148055, 17254853, 18307109, 21538109; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="lysine 2,3-aminomutase" /protein_id="NP_389850.1" /db_xref="EnsemblGenomes-Gn:BSU19690" /db_xref="EnsemblGenomes-Tr:CAB13860" /db_xref="GOA:O34676" /db_xref="InterPro:IPR003739" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022459" /db_xref="InterPro:IPR025895" /db_xref="SubtiList:BG13542" /db_xref="UniProtKB/Swiss-Prot:O34676" /translation="MKNKWYKPKRHWKEIELWKDVPEEKWNDWLWQLTHTVRTLDDLK KVINLTEDEEEGVRISTKTIPLNITPYYASLMDPDNPRCPVRMQSVPLSEEMHKTKYD LEDPLHEDEDSPVPGLTHRYPDRVLFLVTNQCSMYCRYCTRRRFSGQIGMGVPKKQLD AAIAYIRETPEIRDCLISGGDGLLINDQILEYILKELRSIPHLEVIRIGTRAPVVFPQ RITDHLCEILKKYHPVWLNTHFNTSIEMTEESVEACEKLVNAGVPVGNQAVVLAGIND SVPIMKKLMHDLVKIRVRPYYIYQCDLSEGIGHFRAPVSKGLEIIEGLRGHTSGYAVP TFVVDAPGGGGKIALQPNYVLSQSPDKVILRNFEGVITSYPEPENYIPNQADAYFESV FPETADKKEPIGLSAIFADKEVSFTPENVDRIKRREAYIANPEHETLKDRREKRDQLK EKKFLAQQKKQKETECGGDSS*" /label="kamA CDS" gene complement(1807552..1808967) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /label="kamA gene" promotor_-35 1808223..1808226 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1808242..1808261 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1808247 /Source="Nicolas_upshifts" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1808996..1809823) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21538109, 24914178" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epsilon-amino-beta-lysine acetyl transferase" /protein_id="NP_389851.1" /db_xref="EnsemblGenomes-Gn:BSU19700" /db_xref="EnsemblGenomes-Tr:CAB13861" /db_xref="GOA:O34895" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022525" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13543" /db_xref="UniProtKB/Swiss-Prot:O34895" /translation="MLKSIKSSGVTAVLDHDGFNKRIRVVRYDGAIEKALPDIVAAAK EENAEKIIVYAKQHDEPILAKQLFAPEGYLKGYYLGHSACVMVRYLSESRRQTDSYTE EQEIIEAIYRTAPRLRNDSTPVFTMRKAETNDMYQLSMLYKKVFRTYPTPVFDPAYIE KTMNANTVYYIMLDHDRLISAASAEINPELGHAEITDCAVLPEYRGHSLTSFLIEALE KEMAGEDIVHVFSLARASSFGMNAVLYHSGYQYGGRLINNCFIAEGLENMNIWCKQL* " /label="kamB CDS" gene complement(1808996..1809823) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /label="kamB gene" CDS complement(1809801..1811111) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /EC_number="3.5.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative deacetylase" /protein_id="NP_389852.1" /db_xref="EnsemblGenomes-Gn:BSU19710" /db_xref="EnsemblGenomes-Tr:CAB13862" /db_xref="GOA:O34984" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR033687" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12569" /db_xref="UniProtKB/Swiss-Prot:O34984" /translation="MRMQDIERKVIEWLDQHSAKAIRLLKRLIGEKSTLGSEFNAQAV VLEKLRQFHMDIDVWEPSIKQLKQHPYFKSNRSDFHESPNIVAKKTGAGGGRSLILNG HIDVVPEGSVKDWKYEPYQAVEENGKIYGRGSTDMKGGNTALLFALEALHACDVKLKG DVLFQSVVDEECGGAGTLSAIMRGYRADGALIPEPTNMKLFIKQQGSMWFRITVKGLS AHGGTRYEGVSAIEKSMHVITAIQELEKVRNARISDPLYDNIPIPVPVNIGTISGGAW PSSVADRVVIEGRCGIAPHEKPEAVKLELENWLKDLEYHDEWFKRHPVQVEWFGAQWL PNDLPDDHPLISVLQSAYQKMKQTEPIIEASPWGTDGGLLYHAGDTPVIVFGPGETKT AHQANEYIEVEAMIESAKIIALFVMDWCGLHTDGEDADAQVNKE*" /label="yodQ CDS" gene complement(1809801..1811111) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /label="yodQ gene" CDS complement(1811120..1811773) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyloate-acetoacetate CoA-transferase" /protein_id="NP_389853.1" /db_xref="EnsemblGenomes-Gn:BSU19720" /db_xref="EnsemblGenomes-Tr:CAB13863" /db_xref="GOA:O34466" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="SubtiList:BG13544" /db_xref="UniProtKB/Swiss-Prot:O34466" /translation="MGLGVAEREQIAKRAATEIKQGMIVNLGIGIPSLVPNFLKPDMQ VMFQAENGVLGIGESPEKGEEDAHLCNAAGYPVRAVKGASYFDTTMSFAMIRKGKIDI TILGALQVSQSGDLANWLVPGKKVPGMGGAMELAQKAKKVVVVMSHTDQKGRPKLTER CTLPLTAAGCVDLIITEKAVLEVDSHHFILKELMNGSTIDEVTRLTEAEIKIDMPFS* " /label="yodR CDS" gene complement(1811120..1811773) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /label="yodR gene" CDS complement(1811758..1812447) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxoacid CoA-transferase" /protein_id="NP_389854.1" /db_xref="EnsemblGenomes-Gn:BSU19730" /db_xref="EnsemblGenomes-Tr:CAB13864" /db_xref="GOA:O34317" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="SubtiList:BG13545" /db_xref="UniProtKB/Swiss-Prot:O34317" /translation="MAPFQKAISIDTAIADVRDGSVLMFGGFGGVGSPPSLIEAILDS GVTDLTVICNDAGFPDIGIGPLIVNQRVKTLIASHIGSNPVAGKQMTEGTLEVQFSPQ GTLAERIRAGGAGLGGILTDVGIDNQMVCEKKDIVTVAGKRYLIEEALTADFAFINAY IADEFGNLTYDKTARNMNPLMAMAARRTFAEAERIVPMGEISEEMIVTPGVFVEGVVR SEGVKWKWAWE*" /label="yodS CDS" gene complement(1811758..1812447) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /label="yodS gene" CDS complement(1812454..1813788) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /EC_number="2.6.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10839984, 15150230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminovalerate aminotransferase" /protein_id="NP_389855.1" /db_xref="EnsemblGenomes-Gn:BSU19740" /db_xref="EnsemblGenomes-Tr:CAB13865" /db_xref="GOA:O34662" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13546" /db_xref="UniProtKB/Swiss-Prot:O34662" /translation="MSSYLIKPELSSAYPVVSYAKGSYVYDQTGKKYLDGSSGAVTCN IGHGVRDVTEKLKEQLDQVSFAYRSQFTSEPAEQLAALLAQELPGDVNWSFFVNSGSE AIETAMKIAIQYWQEKKQTQKSIFLSRWSSYHGITLGALSLSGFYERRYRFTHLIERY PAISAPHIYRLNHETEEDFVQTAADELDTMIKRIGSQFIAGFVAEPIIGAAGAAITPP PGYYERLSEVCRTHDVLFIADEVMTGLGRTGRMLATEHWDTVPDIAVLGKGLGAGYAP IAAAVVSDSIIETIKQGSGVIMSGHTYSAHPYSAKAALEVLRYVLKHGLIKQSEKKGA VLKKKLDEAASQSGIIGEVRGKGLLLGIEFVADQKTKKVFPPEQAITQLIVSEAKKRG LIVYPSKAGIDSGEGDAVIIAPPFTISDGEMEELISIFSETVAAVEKNLKKD*" /label="yodT CDS" gene complement(1812454..1813788) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /label="yodT gene" CDS complement(1813769..1813924) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513966.1" /translation="MLDAEISKEPSLLGRLFLCEKVFAGNVMPPFGHSYNMVKGVLRW EHEQLFD*" /label="conserved hypothetical protein CDS" gene complement(1813769..1813924) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /label="gene" promotor_-10 complement(1813807..1813825) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1813823) /Source="Nicolas_upshifts" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1813841..1813846) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1813918..1814151) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a type I toxin family (sporulation operon)" /protein_id="YP_003097746.2" /db_xref="EnsemblGenomes-Gn:BSU19749" /db_xref="EnsemblGenomes-Tr:CAX52643" /db_xref="GOA:C0H435" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H435" /translation="MSGCILYFIISLHEIGVCTNHLGLGPHKMSYIVIRKDENSMYGY SGYGYGFGCGTNTFVLIVVLFILLIIVGAAFIC*" /label="yoyG CDS" gene complement(1813918..1814151) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /label="yoyG gene" downshifts complement(1813925) /Source="Nicolas_upshifts" /id="D1086" /incds=0 /nref=96 /ntot=237 /MaxReadThrough="2.70127" /MaxDrop="7.98506" /score="25.3834194" /energy="-16.5" /TU="NA" /idTUdmin="U1620" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 1814027..1814031 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1814040..1814054 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1814055 /Source="Nicolas_upshifts" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1814056..1814075) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1814065) /Source="Nicolas_upshifts" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1814090..1814099) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1814111..1814890) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 7592393, 10066829, 27260256" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 7592393, 10066829, 27260256; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389856.1" /db_xref="EnsemblGenomes-Gn:BSU19750" /db_xref="EnsemblGenomes-Tr:CAB13866" /db_xref="GOA:P42093" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11197" /db_xref="UniProtKB/Swiss-Prot:P42093" /translation="MTGHYSKTEHQYILLTSESASFDHYSVYRDPQLPQIFSHNFVQL HDTFPLERLLNFLPSVPKLLDANYLHLKASPQHVFPLGLKQSLVKSGFVVEDELLYDM KLSDWKGQMGHPLTAWGTAKSLSDGSSIMKIYDSIYIGEAIAEQKLKRKYPFYEADII ILVVCYSDQAQKVPIGCGELFIDHQEKTAKIEEVAILDQFQRKGYGSILVKEMLSIAK SLGMEAAYLVAASTDGATQFYEKLTFKKYERVHTVFHYFLT*" /label="cgeE CDS" gene complement(1814111..1814890) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /label="cgeE gene" CDS complement(1814919..1816199) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in maturation of the outermost layer of the spore" /protein_id="NP_389857.1" /db_xref="EnsemblGenomes-Gn:BSU19760" /db_xref="EnsemblGenomes-Tr:CAB13867" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11196" /db_xref="UniProtKB/Swiss-Prot:P42092" /translation="MGEKVSIILTSYNKPDYLQKAIESVIQQTHDLWELFIMDDHSNA ETTAVIHKYLHDRRIQYHNSFVHPADRLKTARYATLINSALPFADGDYISYLTDDTVY HPERLSRMVQEFSHKPEAQAVYSKQKVVHVNERGEEISHFYRNANAVLDQAAFQVDHC SVMHRRSLLNLIHHKFGGYWDDDMKHWNHGDAIFWARLNNFTPFLPINEVLDTTYKTP DSFQNAYRFLPADLIDGSFVKGSDQNVYFFDQGVRHPVGEKWGFLYLNRTVAVPDPYL FQYRIGKILNIPNYILVKEADHPAIFYIEAGKKRRIVDQYAFQFYQFQRKDIVTIGKE EMETLPEGPPITWKRSELIKNPPGRRLFFIEREPFLFLNGVFHPISEQVTRKFFLHQK PISASFRNIQQFPIGKPFYPVYDEIIKKLNIATE*" /label="cgeD CDS" gene complement(1814919..1816199) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /label="cgeD gene" promotor_-10 complement(1815567..1815585) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1815583) /Source="Nicolas_upshifts" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1815599..1815606) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1816167..1816185) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1816177) /Source="Nicolas_upshifts" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1816201..1816206) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1816264..1816569) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389858.1" /db_xref="EnsemblGenomes-Gn:BSU19770" /db_xref="EnsemblGenomes-Tr:CAB13868" /db_xref="SubtiList:BG11195" /db_xref="UniProtKB/Swiss-Prot:P42091" /translation="MDLEKQVDREENQDDLHFILLLLILLIRQSSSEGNPSDLRRQLV FAKELGVPVSKVNLINGDTLQNVIVKEVLTDLVIFQNPLNNTRSHVSLSSVVSWGAF* " /label="cgeC CDS" gene complement(1816264..1816569) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /label="cgeC gene" downshifts complement(1816397) /Source="Nicolas_upshifts" /id="D1087" /incds=1 /nref=2 /ntot=28 /MaxReadThrough="5.32389" /MaxDrop="2.61092" /score="23.1569137" /energy="-13.4" /TU="U1623" /idTUdmin="U1623" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1816593..1816612) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-10" upshifts complement(1816608) /Source="Nicolas_upshifts" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="upshifts" promotor_-35 complement(1816626..1816635) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-35" promotor_-35 1816705..1816714 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1816728..1816747 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1816728 /Source="Nicolas_upshifts" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1816749) /Source="Nicolas_upshifts" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1816751..1816765) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1816774..1816778) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1816774..1817175 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:759239, 14702409, 15621419, 19933362, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 759239, 14702409, 15621419, 19933362, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outermost layer component" /protein_id="NP_389859.1" /db_xref="EnsemblGenomes-Gn:BSU19780" /db_xref="EnsemblGenomes-Tr:CAB13869" /db_xref="SubtiList:BG11193" /db_xref="UniProtKB/Swiss-Prot:P42089" /translation="MSSENAQLKKDLIKAVLSPLFPTATEGGENMDSNLKALLDAAID QKVDESETVTAESILDPSLPARWIFARITPGTTISIVTDSGDMIGPVVFVAFDQVHGI VFVTQESSVTPAGQATTLIDVDKVESVTFFS*" /label="cgeA CDS" gene 1816774..1817175 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /label="cgeA gene" CDS 1817182..1818135 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389860.2" /db_xref="EnsemblGenomes-Gn:BSU19790" /db_xref="EnsemblGenomes-Tr:CAB13870" /db_xref="InterPro:IPR024542" /db_xref="SubtiList:BG11194" /db_xref="UniProtKB/Swiss-Prot:P42090" /translation="MKVLYIQSGYGGIYSYFDRWAEECFQNTHTEYMIADKPEAESLM KIEAFQPDFTLMMVGDRVPHDWLTWLKGKDIPVYVWLTEDPFYMDISLQVIKLADAIL TIEQNAALYYQELGYQNVYYVPIPVNHRLFKKMGTEHSYHSNLLIIGYPYPNRVQLMK EAVHLPFTVRVIGKEWGKYLPKKVLKQPHIDVVSTWVPPEQAVHYYNGADIVINAHRP YHFAFNQNTMRIKNASFNNRTFDIAACEAFQLTDLPAAHPFSSIISYHGMNDFKEKAA FYINHPEERQKAAAANYKETVPAFTFDELPAKLKAIHLALS*" /label="cgeB CDS" gene 1817182..1818135 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /label="cgeB gene" downshifts 1818125 /Source="Nicolas_upshifts" /id="D1088" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="2.94229" /MaxDrop="5.87549" /score="22.1420541" /energy="-9" /TU="NA" /idTUdmin="U1624" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1818206..1819354) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /EC_number="3.1.3.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phytase" /protein_id="NP_389861.1" /db_xref="EnsemblGenomes-Gn:BSU19800" /db_xref="EnsemblGenomes-Tr:CAB13871" /db_xref="GOA:P42094" /db_xref="InterPro:IPR003431" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11198" /db_xref="UniProtKB/Swiss-Prot:P42094" /translation="MKVPKTMLLSTAAGLLLSLTATSVSAHYVNEEHHFKVTAHTETD PVASGDDAADDPAIWVHEKHPEKSKLITTNKKSGLVVYDLDGKQLHSYEFGKLNNVDL RYDFPLNGEKIDIAAASNRSEGKNTIEVYAIDGDKGKLKSITDPNHPISTNISEVYGF SLYHSQKTGAFYALVTGKQGEFEQYEIVDGGKGYVTGKKVREFKLNSQTEGLVADDEY GNLYIAEEDEAIWKFNAEPGGGSKGQVVDRATGDHLTADIEGLTIYYAPNGKGYLMAS SQGNNSYAMYERQGKNRYVANFEITDGEKIDGTSDTDGIDVLGFGLGPKYPYGIFVAQ DGENIDNGQAVNQNFKIVSWEQIAQHLGEMPDLHKQVNPRKLKDRSDG*" /label="phyC CDS" gene complement(1818206..1819354) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /label="phyC gene" downshifts complement(1818223) /Source="Nicolas_upshifts" /id="D1089" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="2.64059" /MaxDrop="5.59857" /score="17.7154517" /energy="-8.7" /TU="NA" /idTUdmin="U1629" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" promotor_-35 1819367..1819371 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1819380..1819399) /Source="Nicolas_upshift_promotors" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1819387..1819406 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1819389) /Source="Nicolas_upshifts" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 1819397 /Source="Nicolas_upshifts" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1819658..1819666 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1819680..1819699 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1819683 /Source="Nicolas_upshifts" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="upshifts" CDS 1819724..1820749 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014664318.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="polysaccharide biosynthesis protein" /protein_id="WP_003230816.1" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /translation="MPKQQTAELKPFFHNKTVLVTGGTGSIGSQIVKRLLMLTPKQVI VFSKDDSKQYVMSQKYAEDKRLLFVLGDVRDHRRVNQVMKGVDIVFHAAALKQVPTCE DHPFEAIQTNLIGGQNVVEAALSHRVQHVINISTDKAVSPVNTMGATKLLSEKLFHQA NRHVQNKGTLFCSVRFGNVLGSRGSVIPILFEQMMEGEPLTITDKNMTRFFMSIDDAA TLTLQSAAITKGGETFIFKMESLKLEELIHGFEEYASQHGLPRPAAVEVGKRPGEKLH EELTSPHEIESLYEWGNLYAILPEPEKHPDFRKVNLPGYQSDQAPLITKERIAQIIEE LHQEKKA*" /label="Delta6_BSU_19810-BSU_21670" gene 1819724..1820749 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /label="Delta6_BSU_19810-BSU_21670" downshifts 1820127 /Source="Nicolas_upshifts" /id="D1090" /incds=0 /nref=18 /ntot=39 /MaxReadThrough="0.75679" /MaxDrop="7.79081" /score="-6.65536786" /energy="-8.7" /TU="NA" /idTUdmin="U1628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 <1820129..1820133 /Source="Nicolas_upshift_promotors" /id="U1702" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1418 /SigmaFactorBS="tttcatttttgacctcacagccactaATAGTTTCCActaaga aaagtagTAAGTATCTTAAAAAACAGAtaaagctgtatctcctgtgaacacaatgggt g" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" SCAR 1820143..1820144 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta_SP_beta" downshifts 1820741 /Source="Nicolas_upshifts" /id="D1134" /incds=0 /nref=22 /ntot=177 /MaxReadThrough="2.90949" /MaxDrop="5.54327" /score="-2.31796312" /energy="-13.5" /TU="NA" /idTUdmin="U1701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1820793..1821224) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /EC_number="1.8.4.12" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15680230, 16803968, 17031545, 18239417, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine R-sulfoxide reductase" /protein_id="NP_390051.1" /db_xref="EnsemblGenomes-Gn:BSU21680" /db_xref="EnsemblGenomes-Tr:CAB14086" /db_xref="GOA:P54155" /db_xref="InterPro:IPR002579" /db_xref="InterPro:IPR011057" /db_xref="InterPro:IPR028427" /db_xref="PDB:2KZN" /db_xref="PDB:3E0O" /db_xref="SubtiList:BG11628" /db_xref="UniProtKB/Swiss-Prot:P54155" /translation="MAYNKEEKIKSLNRMQYEVTQNNGTEPPFQNEYWDHKEEGLYVD IVSGKPLFTSKDKFDSQCGWPSFTKPIEEEVEEKLDTSHGMIRTEVRSRTADSHLGHV FNDGPGPNGLRYCINSAALRFVPKHKLKEEGYESYLHLFNK*" /label="msrB CDS" gene complement(1820793..1821224) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /label="msrB gene" downshifts complement(1820798) /Source="Nicolas_upshifts" /id="D1135" /incds=0 /nref=229 /ntot=262 /MaxReadThrough="2.46559" /MaxDrop="6.77483" /score="1.42817565" /energy="-12.3" /TU="NA" /idTUdmin="U1704" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1821225..1821758) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /EC_number="1.8.4.11" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9573155, 16803968, 17062561, 18662407" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573155, 16803968, 17062561, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine S-sulfoxide reductase" /protein_id="NP_390052.1" /db_xref="EnsemblGenomes-Gn:BSU21690" /db_xref="EnsemblGenomes-Tr:CAB14087" /db_xref="GOA:P54154" /db_xref="InterPro:IPR002569" /db_xref="InterPro:IPR036509" /db_xref="SubtiList:BG11627" /db_xref="UniProtKB/Swiss-Prot:P54154" /translation="MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPT YEEVCSETTGHREAVQITFHPDVFPYEKLLELFWQQIDPTDAGGQFADRGSSYRAAIF YHNDKQKELAEASKQRLAESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRY RTGSGRAGFISEHWGAK*" /label="msrA CDS" gene complement(1821225..1821758) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /label="msrA gene" promotor_-35 1821762..1821768 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1821779..1821889 /Source="Nicolas_S_feature" /locus_tag="new_2288083_2288193" /HighExp="B60, Lbstat, Cold, M9-stat, T4.0H, LoTm, S0, T3.30H, BC, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S817" upshifts 1821779 /Source="Nicolas_upshifts" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1821781..1821800 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1821786..1821805) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1821806) /Source="Nicolas_upshifts" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1821821..1821822) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1821890..1822315 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9571784, 10809700; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_390053.1" /db_xref="EnsemblGenomes-Gn:BSU21700" /db_xref="EnsemblGenomes-Tr:CAB14088" /db_xref="GOA:P54182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11626" /db_xref="UniProtKB/Swiss-Prot:P54182" /translation="MKVRTQMMYDMETLLRKVFKQIRNEINEILDKELSRNEFTILRI LSEQGPKKVTEFAPILEVSASHITAVTDALVEKEWITRIRSKEDRRIIRIHITEAGEK VLQHFNEKKTEYFFKRFDCYTDAELATLIELFSKLDKKR*" /label="ypoP CDS" gene 1821890..1822315 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /label="ypoP gene" downshifts 1822303 /Source="Nicolas_upshifts" /id="D1136" /incds=0 /nref=92 /ntot=248 /MaxReadThrough="4.04021" /MaxDrop="5.35086" /score="-1.90494373" /energy="-7" /TU="U1703" /idTUdmin="U1703" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 1822348..1823579 /Source="Nicolas_S_feature" /locus_tag="new_2288652_2289883" /HighExp="Cold, ferm, nit, C30, S0, Lbstat, T3.30H, T-4.40H, T5.0H, G135" /AntisenseName="dinF" /AntisenseCor="0.270994122332881" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S818" CDS complement(1822365..1823702) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11583854, 15849754, 16850406, 22933559, 26246409; Product type t : transporter" /codon_start=1 /transl_table=11 /product="damage inducible, Na+ driven multidrug efflux pump" /protein_id="NP_390054.1" /db_xref="EnsemblGenomes-Gn:BSU21710" /db_xref="EnsemblGenomes-Tr:CAB14089" /db_xref="GOA:P54181" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG11625" /db_xref="UniProtKB/Swiss-Prot:P54181" /translation="MKAYDFTQGNVLKQLVLFSMPIMLGNALQVSFQFIDSLWIGNLL GAKALGAAAVSSTIVLTVLSFILGLNNATLTILSQQKGKDDIKGMASYINAFVVLLTG LSIGFGAAGFFLSELLLRLLKTPESMIPLAETYLQIQFIGILFLFGYNFISTVLRALG DSKTPLRFIAFAVVLNTVLAPLFISVFRMGIAGAAYSTILSQGIAFLYGLFYVIKHKL VPFSIPRMPKWEESALILKLGIPAGLQMMVITGGMMAIMSVVNSYGDHVVSGFGAVQR LDSIITLPAMAAGTAVNSMAGQNIGIGNEKRVGTIARLGVIAVISCMLVIAVMIWVFG KYLIRLFISEPDAVAFGEQYLKWIAFFYPFIGVNFVLNGIVRAAGAMLQVLVLNLISF WVLRYPFTALFSAWLGQKGIGLGIGMSFLFSSCAAFLYYRYGRWKAMKLFTEK*" /label="dinF CDS" gene complement(1822365..1823702) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /label="dinF gene" CDS complement(1823774..1823968) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390055.1" /db_xref="EnsemblGenomes-Gn:BSU21720" /db_xref="EnsemblGenomes-Tr:CAB14090" /db_xref="GOA:P54180" /db_xref="InterPro:IPR035403" /db_xref="SubtiList:BG11624" /db_xref="UniProtKB/Swiss-Prot:P54180" /translation="MKRIYQYFSLLSFTFSLYFGWLAYHHLAAEDMDQMYLNVSYCAL FLSVMVFTFGMRDRKKTDKS*" /label="ypmT CDS" gene complement(1823774..1823968) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /label="ypmT gene" downshifts complement(1823787) /Source="Nicolas_upshifts" /id="D1137" /incds=0 /nref=123 /ntot=248 /MaxReadThrough="3.84998" /MaxDrop="4.80224" /score="-2.26655222" /energy="-15.5" /TU="U1705" /idTUdmin="U1707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1823981..1824544) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390056.1" /db_xref="EnsemblGenomes-Gn:BSU21730" /db_xref="EnsemblGenomes-Tr:CAB14091" /db_xref="GOA:P54179" /db_xref="InterPro:IPR018672" /db_xref="SubtiList:BG11623" /db_xref="UniProtKB/Swiss-Prot:P54179" /translation="MNKWKRLFFILLAINFILAAGFVALVLLPGEQAQVKDASESEYG FQVTSTKESLAAFVNSYLNDKASNKLDYKVEIDDDVHVAGKIKAFSTSIDAFIAFEPT VKKNGDVELNVTKFSLGKLSIPISFVLNYMDSFYELPSFVHVHPGDKSIEVRLSEMPL TNGMYVKADKINLEKDEIEFSYYHPKQ*" /label="ypmS CDS" gene complement(1823981..1824544) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /label="ypmS gene" CDS complement(1824554..1825321) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17220230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported lipase/acylhydrolase (lipoprotein)" /protein_id="NP_390057.1" /db_xref="EnsemblGenomes-Gn:BSU21740" /db_xref="EnsemblGenomes-Tr:CAB14092" /db_xref="GOA:P40766" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11022" /db_xref="UniProtKB/Swiss-Prot:P40766" /translation="MKLRIFSIMASLILLLTACTSIRTSSEGKQKAHETKTKEHIVIA AVGDSLTEGVGDPDGKGYVGKVADSIRSDKQVKTVDVKNYAVKGNRSDDLLEKLKDKK VQKGIKDADYVFFTIGGNDLMKILRQNFLQLTVEPFQEAEKPYEKRFEKIISEIRELN DHAELIYVSMYNPFTFTLSELNEINGVVTDWNHIAEKELKKDKHAKIVHIEDLFNQKS DSSRISEEDDFHPNGTGYSLIAKRVYQAIKKEGLPKE*" /label="ypmR CDS" gene complement(1824554..1825321) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /label="ypmR gene" promotor_-10 complement(1825345..1825364) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1825362) /Source="Nicolas_upshifts" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1825375..1825382) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1825399..1825980) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10837475, 14680962, 14766920, 16305244, 19027886, 29131589" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10837475, 14680962, 14766920, 16305244, 19027886, 29131589; Product type f : factor" /codon_start=1 /transl_table=11 /product="assembly factor BSco of the Cu(A) site of cytochrome c oxidase" /protein_id="NP_390058.2" /db_xref="EnsemblGenomes-Gn:BSU21750" /db_xref="EnsemblGenomes-Tr:CAB14093" /db_xref="GOA:P54178" /db_xref="InterPro:IPR003782" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ON4" /db_xref="PDB:1XZO" /db_xref="SubtiList:BG11622" /db_xref="UniProtKB/Swiss-Prot:P54178" /translation="MKVIKGLTAGLIFLFLCACGGQQIKDPLNYEVEPFTFQNQDGKN VSLESLKGEVWLADFIFTNCETICPPMTAHMTDLQKKLKAENIDVRIISFSVDPENDK PKQLKKFAANYPLSFDNWDFLTGYSQSEIEEFALKSFKAIVKKPEGEDQVIHQSSFYL VGPDGKVLKDYNGVENTPYDDIISDVKSASTLK*" /label="scuA CDS" gene complement(1825399..1825980) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /label="scuA gene" S_feature complement(1825981..1826096) /Source="Nicolas_S_feature" /locus_tag="new_2292285_2292400_c" /HighExp="T5.0H, T3.30H, S2, T3.0H, BC, T2.30H, T4.0H, S1, HiOs, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S819" CDS complement(1826128..1826379) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15060025, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390059.1" /db_xref="EnsemblGenomes-Gn:BSU21760" /db_xref="EnsemblGenomes-Tr:CAB14094" /db_xref="InterPro:IPR019687" /db_xref="SubtiList:BG11621" /db_xref="UniProtKB/Swiss-Prot:P54177" /translation="MLLKSLEFKRGDGIQVKVTEIPVLKEDEHYFFMLHHHLQFYLKE VFSSNSRAKVYSFRHYMKRRMKWADYQAVFHQEVLKHNA*" /label="ypmP CDS" gene complement(1826128..1826379) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /label="ypmP gene" downshifts complement(1826141) /Source="Nicolas_upshifts" /id="D1138" /incds=0 /nref=2 /ntot=117 /MaxReadThrough="4.5803" /MaxDrop="2.91481" /score="26.0320926" /energy="-21.8" /TU="U1707" /idTUdmin="U1706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1826402..1826421) /Source="Nicolas_upshift_promotors" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1826416) /Source="Nicolas_upshifts" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1826465..1827733) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /EC_number="4.3.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine dehydratase" /protein_id="NP_390060.1" /db_xref="EnsemblGenomes-Gn:BSU21770" /db_xref="EnsemblGenomes-Tr:CAB14095" /db_xref="GOA:P37946" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001721" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011820" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10673" /db_xref="UniProtKB/Swiss-Prot:P37946" /translation="MKPLLKENSLIQVKDILKAHQNVKDVVIHTPLQRNDRLSERYEC NIYLKREDLQVVRSFKLRGAYHKMKQLSSEQTENGVVCASAGNHAQGVAFSCKHLGIH GKIFMPSTTPRQKVSQVELFGKGFIDIILTGDTFDDAYKSAAECCEAESRTFIHPFDD PDVMAGQGTLAVEILNDIDTEPHFLFASVGGGGLLSGVGTYLKNVSPDTKVIAVEPAG AASYFESNKAGHVVTLDKIDKFVDGAAVKKIGEETFRTLETVVDDILLVPEGKVCTSI LELYNECAVVAEPAGALSVAALDLYKDQIKGKNVVCVVSGGNNDIGRMQEMKERSLIF EGLQHYFIVNFPQRAGALREFLDEVLGPNDDITRFEYTKKNNKSNGPALVGIELQNKA DYGPLIERMNKKPFHYVEVNKDEDLFHLLI*" /label="ilvA CDS" gene complement(1826465..1827733) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /label="ilvA gene" promotor_-10 complement(1827767..1827786) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1827786) /Source="Nicolas_upshifts" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1827798..1827805) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1827940..1827959 /Source="Nicolas_upshift_promotors" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1827943 /Source="Nicolas_upshifts" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="upshifts" CDS 1827982..1828977 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12399512, 16585774, 19763274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399512, 16585774, 19763274; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional enhancer involved in BCAA homeostasis" /protein_id="NP_390061.1" /db_xref="EnsemblGenomes-Gn:BSU21780" /db_xref="EnsemblGenomes-Tr:CAB14096" /db_xref="GOA:P54156" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013668" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11619" /db_xref="UniProtKB/Swiss-Prot:P54156" /translation="MNSAPKLNTFQHLIGEHQTFLEAKRIAKQFSLSELPVLITGKIG TGKNHFAHAIHLESSRSNEPFISVNCSTHSEETLIHELFGPNGNTGVFQKAVRGTLFL DDVWRMPASVQAQLLKALDSDTEKPRMICASADRSVEHTFRQDLFYRLNILTLTLPEL SERKSDIPLLTQHFLSNSGQQLLIDPSVFPVLEKHAFEGNVRELKNAADYMAAVSSGG TIQPYDLPPYIRGTIDGKTSKKKAKLLTLMEKAEFLFILETIKVLNEKGEPASRRIIS EHSKNTQTSLTPQQVRSRLDYLEKKDYVTKSRGRAGTKITFEGLSFIETLKNQMI*" /label="silP CDS" gene 1827982..1828977 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /label="silP gene" CDS 1828998..1829639 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16585774, 16850406, 19763274; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_390062.1" /db_xref="EnsemblGenomes-Gn:BSU21790" /db_xref="EnsemblGenomes-Tr:CAB14097" /db_xref="GOA:P54175" /db_xref="InterPro:IPR004254" /db_xref="InterPro:IPR005744" /db_xref="SubtiList:BG11620" /db_xref="UniProtKB/Swiss-Prot:P54175" /translation="MFTIKEEIANAITHGIGVLLSIPALVFLIIFAANYGSAWDIVSF TIFGVSMLLLYLSSTLLHSITHKKTKDILEIIDHSAIYVLIAGTYTPFLLGPLKGTLG FTLLVIVWSLALGGIVFKIFFVKRFILLSTFVYLVMGWLMIIAVKPLYASLSGAGFSL LFLGGILYSVGTIFYIWKKIPFHHAIWHSFVLGGSAAMFFCVLFYCVKVPFLS*" /label="yplQ CDS" gene 1828998..1829639 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /label="yplQ gene" S_feature 1829640..1830741 /Source="Nicolas_S_feature" /locus_tag="new_2295944_2297045" /HighExp="Cold, C30, Sw, BC, G135, LoTm, Fru, C90, BI, S0" /AntisenseName="ypkP" /AntisenseCor="0.28434605181220002" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S820" CDS complement(1829678..1830298) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 1-acyl-sn-glycerol-3-phosphate acyltransferase" /protein_id="NP_390063.2" /db_xref="EnsemblGenomes-Gn:BSU21800" /db_xref="EnsemblGenomes-Tr:CAB14098" /db_xref="SubtiList:BG11618" /db_xref="UniProtKB/Swiss-Prot:P54174" /translation="MVRYSLLVVYIVYMLLKNMKQLFNQTMLDPRLSYKKQMALVYEQ PKAFLEGCIGISGSVVTIHQPEPIPHGPVLYVHPRLRLAELALIAGYIEEPAGFIANP KVFRLPFIGQWLDRMDVISDGDSEKVYEDVTKQLEKGQSLILSLDGSIDPVELAARYH LPLVMVETKGTDNMQNGSFFKRLKPADIELSFSKAYIPANEKQLRA*" /label="ypkP CDS" gene complement(1829678..1830298) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /label="ypkP gene" downshifts complement(1829704) /Source="Nicolas_upshifts" /id="D1139" /incds=0 /nref=72 /ntot=241 /MaxReadThrough="1.32187" /MaxDrop="5.02823" /score="16.0584527" /energy="-13.4" /TU="NA" /idTUdmin="U1710" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1830299..1830805) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /EC_number="1.5.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2840350, 3918568, 10574451, 12682299, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2840350, 3918568, 10574451, 12682299, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydrofolate reductase" /protein_id="NP_390064.1" /db_xref="EnsemblGenomes-Gn:BSU21810" /db_xref="EnsemblGenomes-Tr:CAB14099" /db_xref="GOA:P11045" /db_xref="InterPro:IPR001796" /db_xref="InterPro:IPR012259" /db_xref="InterPro:IPR017925" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG10795" /db_xref="UniProtKB/Swiss-Prot:P11045" /translation="MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGR KTFESIGRPLPNRKNIVVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYT DLFPYADRLYMTKIHHEFEGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK NSSKAGGF*" /label="dfrA CDS" gene complement(1830299..1830805) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /label="dfrA gene" CDS complement(1830802..1831596) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9648749, 10574451, 19732150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9648749, 10574451, 19732150; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase B" /protein_id="NP_390065.1" /db_xref="EnsemblGenomes-Gn:BSU21820" /db_xref="EnsemblGenomes-Tr:CAB14100" /db_xref="GOA:P11044" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="SubtiList:BG10794" /db_xref="UniProtKB/Swiss-Prot:P11044" /translation="MKQYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPM LTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWR GADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLS CQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNL QLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVSV*" /label="thyB CDS" gene complement(1830802..1831596) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /label="thyB gene" CDS complement(1831680..1832213) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8534098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_390066.1" /db_xref="EnsemblGenomes-Gn:BSU21830" /db_xref="EnsemblGenomes-Tr:CAB14101" /db_xref="GOA:P54173" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="PDB:1TLQ" /db_xref="SubtiList:BG11617" /db_xref="UniProtKB/Swiss-Prot:P54173" /translation="MKKYTMNEMVDITKDMLNKRGVMIEDIARIVQKLQEKYNPNLPL SVCMENVEKVLNKREIIHAVLTGLALDQLAEQKLLPEPLQHLVETDEPLYGIDEIIPL SIVNVYGSIGLTNFGYLDKEKIGIIKELDESPDGIHTFLDDIVAALAAAAASRIAHTH QDLQDEEKEQDEKPVVS*" /label="ypjQ CDS" gene complement(1831680..1832213) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /label="ypjQ gene" downshifts complement(1831685) /Source="Nicolas_upshifts" /id="D1140" /incds=0 /nref=17 /ntot=167 /MaxReadThrough="4.91561" /MaxDrop="4.18561" /score="15.5758445" /energy="-9.3" /TU="U1710" /idTUdmin="U1711" /TUdmin=1232 /isTUend="FALSE" /label="downshifts" promotor_-35 1832143..1832148 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1832159..1833105 /Source="Nicolas_S_feature" /locus_tag="new_2298463_2299409" /HighExp="S5, S6, S4, S8, S7, S3, B36, BT, B60, T5.0H" /AntisenseName="ypjP" /AntisenseCor="-0.72590712604537599" /AntisenseRegPval="-44.6" /CDS_PredictionProba="0.99932399999999999" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S821" upshifts 1832161 /Source="Nicolas_upshifts" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1832165..1832183 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1832231..1832842) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390067.1" /db_xref="EnsemblGenomes-Gn:BSU21840" /db_xref="EnsemblGenomes-Tr:CAB14102" /db_xref="GOA:P54172" /db_xref="InterPro:IPR025616" /db_xref="SubtiList:BG11616" /db_xref="UniProtKB/Swiss-Prot:P54172" /translation="MKLWMRKTLVVLFTIVTFGLVSPPAALMADKPSGQPSSLEQNDY TAFYDEHDLYDDESDDRRDPELLFQSYKEQLLDSAEDQSFLKFGSRIAPVIEDDYRKE ILPKIENVISDYLATLQDDEAYQDVVISSMPSAGKTEKIFNVYNRTTGEDLLRFHVRR DHPPHDGYWFNFHYHTAEDGFQSHHELGSIYWDRNTPPNWMSA*" /label="ypjP CDS" gene complement(1832231..1832842) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /label="ypjP gene" promotor_-10 complement(1832874..1832893) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1832893) /Source="Nicolas_upshifts" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1832906..1832911) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1833062 /Source="Nicolas_upshifts" /id="D1141" /incds=0 /nref=57 /ntot=234 /MaxReadThrough="3.131" /MaxDrop="5.18613" /score="2.81720493" /energy="-15" /TU="U1709" /idTUdmin="U1709" /TUdmin="-527" /isTUend="FALSE" /label="downshifts" CDS complement(1833102..1833875) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /EC_number="2.1.1.242" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22079366; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 16S rRNA m(2)G1516 methyltransferase" /protein_id="NP_390068.2" /db_xref="EnsemblGenomes-Gn:BSU21850" /db_xref="EnsemblGenomes-Tr:CAB14103" /db_xref="GOA:P54171" /db_xref="InterPro:IPR007536" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11615" /db_xref="UniProtKB/Swiss-Prot:P54171" /translation="MITTSYRPSEHTIKTAKQLSKELNMPYCGRNKQTVEHLLKSAER DLLVVGKERFELYTKQGAKFFFHPNTAMFRAKRFLQGEKEPMLRAAGLSEGDTFLDCT LGLGSDAIIASMAVGETGSVVGIEKNHLVSVLVRTGLHSWETGIEELQAAMRRIQVKN GDCFEHIKQLPDNSVDVVYFDPMFHEPVETSDGIAPLRDLAEDSVLHEGCINEAVRVA RKSVVLKDHWKSPRFEQFGFNVMKRKTALFHYGVIQTSP*" /label="rsmJ CDS" gene complement(1833102..1833875) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /label="rsmJ gene" downshifts complement(1833137) /Source="Nicolas_upshifts" /id="D1142" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="2.86923" /MaxDrop="2.91228" /score="9.10717118" /energy="-15" /TU="U1711" /idTUdmin="U1711" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(1833917..1834351) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19653655, 21749987, 22938038, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19653655, 21749987, 22938038, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein disulfide isomerase; bacilliredoxin A (de-bacillithiolation)" /protein_id="NP_390069.1" /db_xref="EnsemblGenomes-Gn:BSU21860" /db_xref="EnsemblGenomes-Tr:CAB14104" /db_xref="InterPro:IPR009474" /db_xref="PDB:3FHK" /db_xref="SubtiList:BG11614" /db_xref="UniProtKB/Swiss-Prot:P54170" /translation="MSMAYEEYMRQLVVPMRRELTGAGFEELTTAEEVENFMEKAEGT TLVVVNSVCGCAAGLARPAATQAVLQNDKTPDNTVTVFAGQDKEATAKMREYFTGQEP SSPSMALLKGKEVVHFIPRHEIEGHDMEEIMKNLTAAFDAHC*" /label="brxA CDS" gene complement(1833917..1834351) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /label="brxA gene" downshifts complement(1833929) /Source="Nicolas_upshifts" /id="D1143" /incds=0 /nref=9 /ntot=210 /MaxReadThrough="5.2935" /MaxDrop="3.1992" /score="21.0933404" /energy="-9.7" /TU="U1711,U1712" /idTUdmin="U1712" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1834380..1834399) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-10" upshifts complement(1834391) /Source="Nicolas_upshifts" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="upshifts" S_feature complement(1834393..1834457) /Source="Nicolas_S_feature" /locus_tag="new_2300697_2300761_c" /HighExp="Sw, S1, BC, Gly, HiOs, HiTm, GM-0.1, UNK1, Fru, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S822" promotor_-35 complement(1834413..1834420) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-35" downshifts complement(1834436) /Source="Nicolas_upshifts" /id="D1144" /incds=0 /nref=32 /ntot=128 /MaxReadThrough="5.73826" /MaxDrop="4.95094" /score="26.9702838" /energy="-25.8" /TU="U1712" /idTUdmin="U1713" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1834458..1836134) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /EC_number="4.2.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12193635, 12618455, 15060025, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193635, 12618455, 15060025, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxy-acid dehydratase" /protein_id="NP_390070.2" /db_xref="EnsemblGenomes-Gn:BSU21870" /db_xref="EnsemblGenomes-Tr:CAB14105" /db_xref="GOA:P51785" /db_xref="InterPro:IPR000581" /db_xref="InterPro:IPR004404" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR020558" /db_xref="SubtiList:BG11532" /db_xref="UniProtKB/Swiss-Prot:P51785" /translation="MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYI DIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIAD SVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKIS LSSVFEGVGAYQAGKINENELQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGN GTILATSPERKEFVRKSAAQLMETIRKDIKPRDIVTVKAIDNAFALDMALGGSTNTVL HTLALANEAGVEYSLERINEVAERVPHLAKLAPASDVFIEDLHEAGGVSAALNELSKK EGALHLDALTVTGKTLGETIAGHEVKDYDVIHPLDQPFTEKGGLAVLFGNLAPDGAII KTGGVQNGITRHEGPAVVFDSQDEALDGIINRKVKEGDVVIIRYEGPKGGPGMPEMLA PTSQIVGMGLGPKVALITDGRFSGASRGLSIGHVSPEAAEGGPLAFVENGDHIIVDIE KRILDVQVPEEEWEKRKANWKGFEPKVKTGYLARYSKLVTSANTGGIMKI*" /label="ilvD CDS" gene complement(1834458..1836134) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /label="ilvD gene" S_feature complement(1836135..1836325) /Source="Nicolas_S_feature" /locus_tag="new_2302439_2302629_c" /HighExp="S1, T-5.40H, MG 45, HiOs, T-4.40H, MG 120, UNK1, MG 25, MG-0.2, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.97" /TUlongSig="SigH" /TUlongPSig=1 /label="S823" promotor_-10 complement(1836314..1836333) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1836325) /Source="Nicolas_upshifts" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1836348..1836351) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1836423..1837556) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase or scaffold" /protein_id="NP_390071.1" /db_xref="EnsemblGenomes-Gn:BSU21880" /db_xref="EnsemblGenomes-Tr:CAB14106" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR014824" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR025989" /db_xref="InterPro:IPR036498" /db_xref="SubtiList:BG11613" /db_xref="UniProtKB/Swiss-Prot:P54169" /translation="MKIKSIEPTPSPNTMKVILTEELPAGKSNNYKPEQAEGAPLVIA EILKIDGVKGVYHVADFLAVERNARYDWKDILPQVRTAFGMESAESAEENRSDQESFG EVKVFVQMFSGIPMQVKLTDGEREERFGLPERFQQAILKLRSEASNVVFERAWKEQGV RFGDFDEIGHDVTEELQAAYSDERLKRLTEAAAQGKGEAKQAVQRKAYKVTLDMLDDE DWKKRYAHLEQMDPKEEDIPVLQKALDDPKVSIRRQAVVYLGMIETPDVLPLLYKALE DKAVSVRRTAGDCLSDIGDPQAIPAMIKSLSDSSKLVRWRAAMFLYEVGDESAIEALR AAEDDPEFEVSLQVKMALERIEHGEEAKGSVWKQMTESRKKGE*" /label="ypgR CDS" gene complement(1836423..1837556) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /label="ypgR gene" downshifts complement(1836439) /Source="Nicolas_upshifts" /id="D1145" /incds=0 /nref=193 /ntot=249 /MaxReadThrough="5.33526" /MaxDrop="6.88149" /score="18.2078317" /energy="-8.7" /TU="U1713" /idTUdmin="U1714" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature complement(1837578..1837597) /Source="Nicolas_upshift_promotors" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1837581) /Source="Nicolas_upshifts" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1837616..1838233) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /EC_number="3.6.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25005104, 27062940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25005104, 27062940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Mn(2+)-dependent (deoxy)ribonucleoside pyrophosphohydrolase" /protein_id="NP_390072.1" /db_xref="EnsemblGenomes-Gn:BSU21890" /db_xref="EnsemblGenomes-Tr:CAB14107" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11612" /db_xref="UniProtKB/Swiss-Prot:P54168" /translation="MKELKQAEQIRTWVQSILTDESSGHDWHHVSRVADLAAYIGEKE KADLFIVETAALVHDLIDVKLPDTVRLSVSEVYDQLVFFGVGKENADRVIHIITRMSF RDRGKLAKEPLSIEGKAVQDADRLDAIGAVGIARAFMFAGAKGHGLYGDEQSAYAHFF HKLLRLKDMMNTDTARELAEERHNFMLQFVRQLEKDIPGIDAETS*" /label="hdhQ CDS" gene complement(1837616..1838233) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /label="hdhQ gene" CDS complement(1838249..1838731) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /EC_number="1.11.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14563871, 14617062, 21749987, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol peroxidase" /protein_id="NP_390073.1" /db_xref="EnsemblGenomes-Gn:BSU21900" /db_xref="EnsemblGenomes-Tr:CAB14108" /db_xref="GOA:P52035" /db_xref="InterPro:IPR000889" /db_xref="InterPro:IPR029759" /db_xref="InterPro:IPR029760" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11530" /db_xref="UniProtKB/Swiss-Prot:P52035" /translation="MSIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQL QELYDTYQQEGLEILGFPCNQFMNQEPGEEADIQEFCETNYGVTFPMFSKVDVNGKNA HPLFVYLTEHAKGMLGTKAIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ *" /label="bsaA CDS" gene complement(1838249..1838731) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /label="bsaA gene" S_feature complement(1838732..1838879) /Source="Nicolas_S_feature" /locus_tag="new_2305036_2305183_c" /HighExp="S2, HiOs, S1, Etha, T2.30H, T3.0H, Lbtran, M0t90, T2.0H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S824" promotor_-10 complement(1838870..1838888) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-10" upshifts complement(1838880) /Source="Nicolas_upshifts" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="upshifts" promotor_-35 complement(1838899..1838907) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-35" promotor_-35 1838933..1838942 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1838955..1838970 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" S_feature 1838957..1839043 /Source="Nicolas_S_feature" /locus_tag="new_2305261_2305347" /HighExp="Salt, T-0.40H, T-1.10H, Heat, T-1.40H, H2O2, T0.0H, Paraq, T0.30H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S825" upshifts 1838957 /Source="Nicolas_upshifts" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" promotor_-35 1839006..1839013 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1839028..1839047 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" upshifts 1839045 /Source="Nicolas_upshifts" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" CDS 1839074..1839979 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /EC_number="2.3.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5001847, 10939241, 11832514, 17056751, 18216013, 28581482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5001847, 10939241, 11832514, 17056751, 18216013, 28581482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="homoserine O-acetyltransferase" /protein_id="NP_390074.2" /db_xref="EnsemblGenomes-Gn:BSU21910" /db_xref="EnsemblGenomes-Tr:CAB14109" /db_xref="GOA:P54167" /db_xref="InterPro:IPR005697" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033752" /db_xref="SubtiList:BG11534" /db_xref="UniProtKB/Swiss-Prot:P54167" /translation="MPINIPTHLPAKQVLESEHIFVMDESRAFHQDIRPQKIIILNLM PKKIQTETQLLRLLGNSPLQVHFTFLIPSTHTPKNTAREHLDEFYTTFSNIRHKRFDG MIITGAPIEHLAFEEVSYWEELKEIMEWSKTNVTSTLHICWGAQAGLYYHYGVEKIQM PKKIFGVFEHTVLSKHERLVRGFDELYYVPHSRHTDINMEQLQAVPELNILTASKEAG VCLIVSKDEKQVFLTGHPEYDTNTLLQEYERDLERNLSTVEAPKHYFAKGSNEPVNRW KAHATLLFMNWLNYYVYQETPYEWD*" /label="metAA CDS" gene 1839074..1839979 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /label="metAA gene" misc_feature 1840014..1840033 /Source="Nicolas_upshift_promotors" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1840028 /Source="Nicolas_upshifts" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" S_feature 1840029..1840209 /Source="Nicolas_S_feature" /locus_tag="new_2306333_2306513" /HighExp="Heat, HiTm, LoTm, C90, M9-stat, HiOs, SMM, UNK1, MG 25, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.999, 0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S826" CDS 1840210..1841358 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /EC_number="2.4.1.315" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose diacylglyceroltransferase" /protein_id="NP_390075.1" /db_xref="EnsemblGenomes-Gn:BSU21920" /db_xref="EnsemblGenomes-Tr:CAB14110" /db_xref="GOA:P54166" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR009695" /db_xref="InterPro:IPR023589" /db_xref="SubtiList:BG11611" /db_xref="UniProtKB/Swiss-Prot:P54166" /translation="MNTNKRVLILTANYGNGHVQVAKTLYEQCVRLGFQHVTVSNLYQ ESNPIVSEVTQYLYLKSFSIGKQFYRLFYYGVDKIYNKRKFNIYFKMGNKRLGELVDE HQPDIIINTFPMIVVPEYRRRTGRVIPTFNVMTDFCLHKIWVHENVDKYYVATDYVKE KLLEIGTHPSNVKITGIPIRPQFEESMPVGPIYKKYNLSPNKKVLLIMAGAHGVLKNV KELCENLVKDDQVQVVVVCGKNTALKESLSALEAENGDKLKVLGYVERIDELFRITDC MITKPGGITLTEATAIGVPVILYKPVPGQEKENANFFEDRGAAIVVNRHEEILESVTS LLADEDTLHRMKKNIKDLHLANSSEVILEDILKESEMMTAKQKAKVLS*" /label="ugtP CDS" gene 1840210..1841358 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /label="ugtP gene" S_feature complement(1840379..1841408) /Source="Nicolas_S_feature" /locus_tag="new_2306683_2307712_c" /HighExp="S8, S7, S6, C30, Lbstat, T0.30H, C90, BT, G135, Fru" /AntisenseName="ugtP" /AntisenseCor="-0.328222465122327" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S827" downshifts 1841354 /Source="Nicolas_upshifts" /id="D1146" /incds=0 /nref=77 /ntot=240 /MaxReadThrough="4.0787" /MaxDrop="4.20549" /score="21.6989702" /energy="-12.1" /TU="U1715,U1717" /idTUdmin="U1716" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1841390..1841409) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1841408) /Source="Nicolas_upshifts" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1841424..1841432) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1841439..1841585 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513973.1" /translation="MELALLLKNKPFRNLTGAPRWCIVEPSFNNESKLDDDKIFFSTW VLQY*" /label="hypothetical protein CDS" gene 1841439..1841585 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /label="gene" promotor_-35 1841478..1841485 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1841499..1841518 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1841510..1841600 /Source="Nicolas_S_feature" /locus_tag="new_2307814_2307904" /HighExp="C90, T5.0H, T3.30H, T3.0H, HiOs, Salt, LoTm, T-3.40H, S3, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S828" upshifts 1841510 /Source="Nicolas_upshifts" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1841601..1841801 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9920884, 16352840" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9920884, 16352840; Product type f: factor" /codon_start=1 /transl_table=11 /product="cold-shock protein, molecular chaperone, RNA-helicase co-factor" /protein_id="NP_390076.1" /db_xref="EnsemblGenomes-Gn:BSU21930" /db_xref="EnsemblGenomes-Tr:CAB14111" /db_xref="GOA:P51777" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11531" /db_xref="UniProtKB/Swiss-Prot:P51777" /translation="MQNGKVKWFNNEKGFGFIEVEGGDDVFVHFTAIEGDGYKSLEEG QEVSFEIVEGNRGPQASNVVKL*" /label="cspD CDS" gene 1841601..1841801 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /label="cspD gene" downshifts 1841816 /Source="Nicolas_upshifts" /id="D1147" /incds=0 /nref=257 /ntot=269 /MaxReadThrough="5.19931" /MaxDrop="8.09346" /score="9.24662311" /energy="-15.6" /TU="U1719" /idTUdmin="U1715" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS complement(1841853..1842035) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16625836, 19251843, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16625836, 19251843, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of degradative enzymes (aprE, nprE, sacB) production or activity" /protein_id="NP_390077.1" /db_xref="EnsemblGenomes-Gn:BSU21940" /db_xref="EnsemblGenomes-Tr:CAB14112" /db_xref="GOA:P68731" /db_xref="SubtiList:BG10699" /db_xref="UniProtKB/Swiss-Prot:P68731" /translation="MDDKDLKLILHKTFIEIYSDLEELADIAKKGKPSMEKYVEEIEQ RCKQNILAIEIQMKIK*" /label="degR CDS" gene complement(1841853..1842035) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /label="degR gene" S_feature 1841861..1842166 /Source="Nicolas_S_feature" /locus_tag="new_2308165_2308470" /HighExp="Cold, LoTm, T4.0H, T3.30H, Pyr, T5.0H, Gly, T3.0H, S0, C30" /AntisenseName="degR" /AntisenseCor="-0.145220711637392" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S829" downshifts complement(1841870) /Source="Nicolas_upshifts" /id="D1148" /incds=0 /nref=133 /ntot=216 /MaxReadThrough="3.75638" /MaxDrop="5.32427" /score="16.1392275" /energy="-7.3" /TU="U1720" /idTUdmin="U1720" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1842096..1842114) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1842128..1842134) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1842132) /Source="Nicolas_upshifts" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1842142..1842148 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1842163..1842174 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1842168 /Source="Nicolas_upshifts" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1842191..1842460 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390078.1" /db_xref="EnsemblGenomes-Gn:BSU21950" /db_xref="EnsemblGenomes-Tr:CAB14113" /db_xref="InterPro:IPR020314" /db_xref="SubtiList:BG13764" /db_xref="UniProtKB/Swiss-Prot:O32007" /translation="MTSEFHNEDQTGFTDKRQLELAVETAQKTTGAATRGQSKTLVDS AYQAIEDARELSQSEELAALDDPEFVKQQQQLLDDSEHQLDEFKE*" /label="ypzA CDS" gene 1842191..1842460 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /label="ypzA gene" downshifts 1842315 /Source="Nicolas_upshifts" /id="D1149" /incds=1 /nref=3 /ntot=82 /MaxReadThrough="6.79633" /MaxDrop="4.11501" /score="22.0113838" /energy="-7.3" /TU="U1719,U1721" /idTUdmin="U1719" /TUdmin="-117" /isTUend="FALSE" /label="downshifts" downshifts 1842443 /Source="Nicolas_upshifts" /id="D1150" /incds=0 /nref=18 /ntot=94 /MaxReadThrough="2.31821" /MaxDrop="6.65627" /score="22.0113838" /energy="-7.3" /TU="NA" /idTUdmin="U1719" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(1842488..1842670) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390079.1" /db_xref="EnsemblGenomes-Gn:BSU21960" /db_xref="EnsemblGenomes-Tr:CAB14114" /db_xref="InterPro:IPR019718" /db_xref="SubtiList:BG11610" /db_xref="UniProtKB/Swiss-Prot:P54165" /translation="MDKKMIFKELTELHDEYCKDCFIKKQFRKEFGKTYAHSFCINKC TVGEKLKQYGDVLTNH*" /label="ypeQ CDS" gene complement(1842488..1842670) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /label="ypeQ gene" downshifts complement(1842508) /Source="Nicolas_upshifts" /id="D1151" /incds=0 /nref=5 /ntot=102 /MaxReadThrough="2.77117" /MaxDrop="4.29218" /score="16.1392275" /energy="-7.3" /TU="NA" /idTUdmin="U1723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1842663..1843343) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12562816, 17905985, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 17905985, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease" /protein_id="NP_390080.2" /db_xref="EnsemblGenomes-Gn:BSU21970" /db_xref="EnsemblGenomes-Tr:CAB14115" /db_xref="GOA:P54164" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11609" /db_xref="UniProtKB/Swiss-Prot:P54164" /translation="MKLRPHLKIEAKGTGSVSFFSEDWLTAQQARTFARELGRFPYMK ELEFEDEKGGSWTLKELEKLTEELAQEPDDITVYFDGSFDKESELAGLGIVIYYSLGG TRHRLRKNKSFRLKTNNEAEYAALYEAIREVRELGASRNSITIKGDSLVVLNQLDGSW PCYDPSHNEWLDKIEALLESLKLTPTYETIQRKDNQEADGLAKKILSHQFVESHTKLD RNGDDDIG*" /label="ypeP CDS" gene complement(1842663..1843343) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /label="ypeP gene" S_feature complement(1843344..1843481) /Source="Nicolas_S_feature" /locus_tag="new_2309648_2309785_c" /HighExp="S5, S4, S6, S8, S7, S3, T5.0H, T4.0H, BT, Pyr" /AntisenseName="ypdP" /AntisenseCor="-0.65324924042743404" /AntisenseRegPval="-33.4" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.92, 0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S830" promotor_-35 1843360..1843365 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1843378..1843397 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1843383 /Source="Nicolas_upshifts" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1843426..1844115 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28208705; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preQ0 transporter (promiscuous)" /protein_id="NP_390081.1" /db_xref="EnsemblGenomes-Gn:BSU21980" /db_xref="EnsemblGenomes-Tr:CAB14116" /db_xref="GOA:P54163" /db_xref="InterPro:IPR003744" /db_xref="SubtiList:BG11607" /db_xref="UniProtKB/Swiss-Prot:P54163" /translation="MFNNSFWIFFAIIHFIIVLLFYKGFGKMGLFVWIGFATVCANLQ VVKTVELFGLTATLGNVMYGTIFFATDVLNEKYGPAEARKAVWLGFSTLLTLTFVMQG VLLFEPASSDISQTALETIFGFLPRVALGSLLAFIFSQTLDVYVYSAIRRIFPSDRLL WLRNGGSTAVSQLFDTFIFTAVAFLGIYPADVWLHIFISTYLIKFAVSLISLPYAYAA KKMIPNDERSS*" /label="queP CDS" gene 1843426..1844115 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /label="queP gene" promotor_-35 complement(1843479..1843495) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1843482) /Source="Nicolas_upshifts" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1843483..1843872) /Source="Nicolas_S_feature" /locus_tag="new_2309787_2310176_c" /HighExp="S5, S4, S6, S7, S8, T5.0H, S3, T4.0H, BT, M9-stat" /AntisenseName="ypdP" /AntisenseCor="-0.645700204826543" /AntisenseRegPval="-32.4" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S831" promotor_-10 complement(1843853..1843872) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1843870) /Source="Nicolas_upshifts" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1843884..1843892) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1844115..1844513 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9888800, 10094689, 15115438, 17905985; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein (no RNase H activity)" /protein_id="NP_390082.1" /db_xref="EnsemblGenomes-Gn:BSU21990" /db_xref="EnsemblGenomes-Tr:CAB14117" /db_xref="GOA:P54162" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11608" /db_xref="UniProtKB/Swiss-Prot:P54162" /translation="MPTEIYVDGASAGNPGPSGIGIFIKHEGKAESFSIPIGVHTNQE AEFLALIEGMKLCATRGYQSVSFRTDSDIVERATELEMVKNITFQPFVEEIIRLKAAF PLFFIKWIPGKQNQKADLLAKEAIRLNEKN*" /label="ypdQ CDS" gene 1844115..1844513 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /label="ypdQ gene" promotor_-35 1844506..1844512 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1844527..1844538 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1844538 /Source="Nicolas_upshifts" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1844555..1844683 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054584.1" /db_xref="EnsemblGenomes-Gn:BSU22000" /db_xref="EnsemblGenomes-Tr:CAE01458" /db_xref="GOA:Q7WY66" /db_xref="InterPro:IPR017526" /db_xref="SubtiList:BG14176" /db_xref="UniProtKB/Swiss-Prot:Q7WY66" /translation="MKKKDKGRLTGGVTPQGDLEGNTHNDPKTELEERAKKSNTKR*" /label="sspL CDS" gene 1844555..1844683 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /label="sspL gene" S_feature 1844684..1845664 /Source="Nicolas_S_feature" /locus_tag="new_2310988_2311968" /HighExp="S8, S7, S5, S6, S4, C30, nit, ferm, Pyr, S3" /AntisenseName="exoA" /AntisenseCor="-0.365099613028674" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S832" CDS complement(1844691..1845581) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:16045613, 17038322, 17905985, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16045613, 17038322, 17905985, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5'3'-exonuclease" /protein_id="NP_390083.1" /db_xref="EnsemblGenomes-Gn:BSU22010" /db_xref="EnsemblGenomes-Tr:CAB14118" /db_xref="GOA:P54161" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="SubtiList:BG11606" /db_xref="UniProtKB/Swiss-Prot:P54161" /translation="MNNNKLLLVDGMALLFRAFFATAVHRNFMINDSGVPTNGVNGFL KHLITAVETFQPTHVVCCWDMGSKTYRNDLFQDYKANRSAPPVELIPQFDLAKEAAAE LGIMNIGFAGYEADDCIGTLADLFANEADITVVTGDRDLLQLLTDKVSVALLQKGIGN YKVYTKETFYEETGVMPKALIDIKALMGDSSDNYPGVKGIGEKTAYKLIREYETIDRL LENLSLLPKGQQGKIQQGLSDLEMSRKLAEIHCSVPLACTLKDALFTLQMEQAADMLR RHQIKGIERMLEKLNAREIV*" /label="exnP CDS" gene complement(1844691..1845581) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /label="exnP gene" downshifts complement(1844728) /Source="Nicolas_upshifts" /id="D1152" /incds=0 /nref=10 /ntot=174 /MaxReadThrough="2.94148" /MaxDrop="4.49836" /score="3.60870815" /energy="-15.6" /TU="U1726" /idTUdmin="U1726" /TUdmin="-284" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1845603..1845622) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1845610) /Source="Nicolas_upshifts" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1845634..1845640) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1845638 /Source="Nicolas_upshifts" /id="D1153" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="0.83304" /MaxDrop="4.41573" /score="0.126370352" /energy="-15" /TU="NA" /idTUdmin="U1725" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(1845682..1845828) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097753.1" /db_xref="EnsemblGenomes-Gn:BSU22019" /db_xref="EnsemblGenomes-Tr:CAX52652" /db_xref="UniProtKB/Swiss-Prot:C0H443" /translation="MLGRTKLGNRNAQANNNAKKKNGFQTHFDSYAGREAEKLIASNK RHND*" /label="ypzF CDS" gene complement(1845682..1845828) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /label="ypzF gene" downshifts complement(1845698) /Source="Nicolas_upshifts" /id="D1154" /incds=0 /nref=253 /ntot=272 /MaxReadThrough="0.89691" /MaxDrop="8.47168" /score="25.632979" /energy="-12" /TU="NA" /idTUdmin="U1727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1845852) /Source="Nicolas_upshifts" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1845853..1845864) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1845879..1845885) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1845903..1846160) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /experiment="publication(s) with functional evidences, PMID:20709900, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore associated protein" /protein_id="NP_390084.1" /db_xref="EnsemblGenomes-Gn:BSU22020" /db_xref="EnsemblGenomes-Tr:CAB14119" /db_xref="InterPro:IPR019688" /db_xref="SubtiList:BG11605" /db_xref="UniProtKB/Swiss-Prot:P54160" /translation="MSEVHKAISAHSSKQHEHIKAFMRLENMRELAIEEAVAKCRNDE PYTTDAINEITEQMNQLAKKGIVPTRRLVSKEMVREYVSRM*" /label="ypbS CDS" gene complement(1845903..1846160) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /label="ypbS gene" promotor_-10 complement(1846180..1846199) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1846195) /Source="Nicolas_upshifts" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1846211..1846218) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1846225..1849806) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /EC_number="3.6.5.5" /experiment="publication(s) with functional evidences, PMID:21205012, 23388828, 23249255, 26842743, 26530236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21205012, 23388828, 23249255, 26842743, 26530236; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dynamin GTPase" /protein_id="NP_390085.1" /db_xref="EnsemblGenomes-Gn:BSU22030" /db_xref="EnsemblGenomes-Tr:CAB14120" /db_xref="GOA:P54159" /db_xref="InterPro:IPR022812" /db_xref="InterPro:IPR027094" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11604" /db_xref="UniProtKB/Swiss-Prot:P54159" /translation="MTDQNRKELLHKTGELYKQFIENQDEQRAAKLAAVMKKAADEEV YIAFTGHYSAGKSSLLNCLLMENILPTSPIPTSANLVVIRNGEKRVRLHTTDGACAEL EGTYQKDKVQQYCKDGEQIESVEIFDRYTEIDSGVAYIDTPGIDSTDDAHFLSAASIL HQADALFYVVHYNHVHAEENVKFLRSIKESIPNVYFIVNQIDRHDETETKFGDYQAQV EEMLCNEGISREALYFTSVTEPDHPFNQMGALREELSRIEQQSKSNMQALTEQKVRNL LKEHTEMLKKDETGAPSFAEQLNIHTGLVQSLRDQLDEAEKQMTEAEKRMQEEINRIL KNANLTPFEMRELAAAFLESQEPSFKTGFFFSKAKTAQERDKRRNAFFSDVAKRTEAE ADWHMIDTLHKLAKVFDVYTAESEKLIQAYRTPLDISIIEHAVKHGAAFSSEYVLQYT KDLAELIRKEAKREAADIIKVLSAMVKERVSKDVQTINDRLVQESEKLVFLQEQARLE NNAREKTDRLWAIWEEESACPMHIDTEWFKSKKTRVAAPEQKQGRSQLTAQPMPKSEI KMEQEMPLQDQIKRFYTLSDILGECSMLLKQTSAFRERVKRLEERKFTLALFGGFSSG KSSFANALVGERVLPSSPTPTTATINKITKPINGNLNKTANVVFKTEDDLTAEILQLT GIPKEPAGRSFTEKWEKAVKKNRLQEEHVKLISNFLLAYEKYQQYIQEQKKLTIPLSE LKPYVAEETTACAVKEVTVYYTCPLTEKGITIVDTPGASSMNKRHTELAFQYIKDADA FFYMTYYQHSFSKGDRSFLRKLGLVKESLSMDKMFFIINAADLAKDKTELETVTDYVS AELVKEGVYEPQLFTVSSKEELVGKPESFYNQFSKVRKHLDRFIEVDVKKASAAQLSS EADKLCETVFQLHQSQHQSREEKEAQKQCLMLSFERTAADIEKRRNSKTIIEKVKKDT REQLYHIAQRLSYFANDLLKSAFHPGLQNGDWKKNVSKAMTTALHEYLFEYIQEIKTL DVRMSGFIERHINEEWLDHFQKTLNEDGYFSVYAGDQHSNGIQLKEVEPEIEERAFEQ ELKEIKSPKQFFEQKGKATFIEAVRMKLTKITEAWIKNEEESLISHYTAHLRRLQEDM GEKAIAQITDQKETYLRGYAEGEHAKEIEMAYQACISWKNSDNTIKM*" /label="dynA CDS" gene complement(1846225..1849806) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /label="dynA gene" S_feature complement(1849807..1849878) /Source="Nicolas_S_feature" /locus_tag="new_2316111_2316182_c" /HighExp="LBGstat, T1.30H, T1.0H, BMM, T2.30H, M9-stat, MG 150, T0.30H, T2.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S833" misc_feature complement(1849868..1849887) /Source="Nicolas_upshift_promotors" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1849878) /Source="Nicolas_upshifts" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="upshifts" S_feature complement(1849923..1850120) /Source="Nicolas_S_feature" /locus_tag="new_2316227_2316424_c" /HighExp="HiOs, B60, GM 25, S7, GM 15, B36, S5, S8, GM 5, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.24118200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S834" downshifts complement(1849966) /Source="Nicolas_upshifts" /id="D1155" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.11615" /MaxDrop="3.46525" /score="27.1937922" /energy="-9.7" /TU="U1730" /idTUdmin="U1730" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1849982..1850071) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513974.1" /db_xref="EnsemblGenomes-Gn:BSU22036" /db_xref="EnsemblGenomes-Tr:CCQ48599" /db_xref="UniProtKB/TrEMBL:L8ECR0" /translation="MTMLFLLGAVCTYSVLIGFVLKGISNKSV*" /label="fbpC CDS" gene complement(1849982..1850071) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /label="fbpC gene" promotor_-10 complement(1850099..1850118) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1850120) /Source="Nicolas_upshifts" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1850133..1850140) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1850142..1850648) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /EC_number="2.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 7726551, 8396117, 19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 7726551, 8396117, 19465653; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkylpyrone methyltransferase (polyketide synthesis)" /protein_id="NP_390086.1" /db_xref="EnsemblGenomes-Gn:BSU22040" /db_xref="EnsemblGenomes-Tr:CAB14121" /db_xref="GOA:P54158" /db_xref="InterPro:IPR007269" /db_xref="SubtiList:BG11603" /db_xref="UniProtKB/Swiss-Prot:P54158" /translation="MFWLLIAILIVQRAAEMAVARQNEQKVKKQGAIEFGESHYPYII TMHILFFLSLIAEVLLMNKQPSSWWLGIAAVILSVQIVRYWALCSLGAYWNTKILVVP GVELVKKGPYKWMKHPNYAVVILEILLIPLLYQAYVTMCLFSIFNAVLLSVRIRAEDK ALQEYSVK*" /label="bpsB CDS" gene complement(1850142..1850648) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /label="bpsB gene" CDS complement(1850652..1851749) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /EC_number="2.3.1.-" /function="15.10: Adaptations to atypical conditions" /experiment="publication(s) with functional evidences, PMID:19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19465653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous alkylpyrone synthase BpsA (polyketide synthesis)" /protein_id="NP_390087.1" /db_xref="EnsemblGenomes-Gn:BSU22050" /db_xref="EnsemblGenomes-Tr:CAB14122" /db_xref="GOA:P54157" /db_xref="InterPro:IPR001099" /db_xref="InterPro:IPR011141" /db_xref="InterPro:IPR012328" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018088" /db_xref="SubtiList:BG11523" /db_xref="UniProtKB/Swiss-Prot:P54157" /translation="MAFILSIGTSLPAYNVNQEKAAEFARYMFQHSFKDIDRLLSSFK NGQIHSRQFVKPIEWYKEGHSFEEKNQIYIEETLKHSRAAVRECLSHPEFFQEAIPYE KVEAVFFVSSTGLSTPSIEARLMNELPFSPYTKRIPIWGLGCAGGASGLARAAEYCKA YPEAFVLVISAELCSLTFQPEDKTKSNLIGTSLFGDGIAAALLCGEKADRRVSKLKLA PKIMDAQSVLMKQSEDVMGWDFTDQGFKVIFSRDIPTLVEKWLKTNVQIFLDKHKLSF HDISVFLAHPGGKKVIDAYIKSLGLSSEKLSSAQSILQKHGNMSSATILYVIKDHLQN GHKKEAERGLIGALGPGFSSELLLFSWEKGA*" /label="bpsA CDS" gene complement(1850652..1851749) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /label="bpsA gene" promotor_-10 complement(1851767..1851778) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1851770) /Source="Nicolas_upshifts" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1851793..1851799) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1851823..1853139) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098051, 12923093, 15549109, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098051, 12923093, 15549109, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xanthine permease" /protein_id="NP_390088.1" /db_xref="EnsemblGenomes-Gn:BSU22060" /db_xref="EnsemblGenomes-Tr:CAB14123" /db_xref="GOA:P42086" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG11080" /db_xref="UniProtKB/Swiss-Prot:P42086" /translation="MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYL VSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTAVSPMIAIGSEYGVSTVYGSIIA SGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNL ALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQ PFYFGAPSFHAAPIITMSIVAIVSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLA VLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFGLFPKIAAFTTIIPS AVLGGAMVAMFGMVIAYGIKMLSRIDFAKQENLLIVACSVGLGLGVTVVPDIFKQLPS ALTLLTTNGIVAGSFTAVVLNIVYNVFSKAKKIEQEADLAEQKTAV*" /label="pbuX CDS" gene complement(1851823..1853139) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /label="pbuX gene" downshifts complement(1851836) /Source="Nicolas_upshifts" /id="D1156" /incds=0 /nref=177 /ntot=215 /MaxReadThrough="1.81377" /MaxDrop="6.3089" /score="32.8866099" /energy="-9" /TU="U1733" /idTUdmin="U1732" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1853136..1853720) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /EC_number="2.4.2.22" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12923093, 15549109, 19381559, 20108980, 20200045" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15549109, 19381559, 20108980, 20200045; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine phosphoribosyltransferase" /protein_id="NP_390089.1" /db_xref="EnsemblGenomes-Gn:BSU22070" /db_xref="EnsemblGenomes-Tr:CAB14124" /db_xref="GOA:P42085" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010079" /db_xref="InterPro:IPR029057" /db_xref="PDB:1Y0B" /db_xref="PDB:2FXV" /db_xref="SubtiList:BG11079" /db_xref="UniProtKB/Swiss-Prot:P42085" /translation="MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFAS RFAKDGITKIVTIESSGIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQ TESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQP GRDELVKLGYRVESLARIQSLEEGKVSFVQEVHS*" /label="xpt CDS" gene complement(1853136..1853720) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /label="xpt gene" misc_RNA complement(1853809..1853909) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswA RNA" gene complement(1853809..1853909) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /label="gswA gene" downshifts complement(1853816) /Source="Nicolas_upshifts" /id="D1157" /incds=0 /nref=8 /ntot=35 /MaxReadThrough="6.97435" /MaxDrop="3.25" /score="36.5247418" /energy="-19.2" /TU="U1732,U1733" /idTUdmin="U1734" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" S_feature complement(1853910..1854050) /Source="Nicolas_S_feature" /locus_tag="new_2320214_2320354_c" /HighExp="dia15, BT, dia5, Diami, C90, LBGtran, Lbtran, Gly, SMMPr, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.291, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S835" CDS complement(1854051..1855556) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /EC_number="3.4.17.19" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7765282, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="metal-dependent carboxypeptidase" /protein_id="NP_390090.1" /db_xref="EnsemblGenomes-Gn:BSU22080" /db_xref="EnsemblGenomes-Tr:CAB14125" /db_xref="GOA:P50848" /db_xref="InterPro:IPR001333" /db_xref="PDB:3HQ2" /db_xref="SubtiList:BG11458" /db_xref="UniProtKB/Swiss-Prot:P50848" /translation="MEIHTYEKEFFDLLKRISHYSEAVALMHWDSRTGAPKNGSEDRA ESIGQLSTDIFNIQTSDRMKELIDVLYERFDDLSEDTKKAVELAKKEYEENKKIPEAE YKEYVILCSKAETAWEEAKGKSDFSLFSPYLEQLIEFNKRFITYWGYQEHPYDALLDL FEPGVTVKVLDQLFAELKEAIIPLVKQVTASGNKPDTSFITKAFPKEKQKELSLYFLQ ELGYDFDGGRLDETVHPFATTLNRGDVRVTTRYDEKDFRTAIFGTIHECGHAIYEQNI DEALSGTNLSDGASMGIHESQSLFYENFIGRNKHFWTPYYKKIQEASPVQFKDISLDD FVRAINESKPSFIRVEADELTYPLHIIIRYEIEKAIFSNEVSVEDLPSLWNQKYQDYL GITPQTDAEGILQDVHWAGGDFGYFPSYALGYMYAAQLKQKMLEDLPEFDALLERGEF HPIKQWLTEKVHIHGKRKKPLDIIKDATGEELNVRYLIDYLSNKYSNLYLL*" /label="ypwA CDS" gene complement(1854051..1855556) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /label="ypwA gene" promotor_no_box complement(1855492..1855592) /Source="Nicolas_upshift_promotors" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1855532) /Source="Nicolas_upshifts" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" downshifts 1855544 /Source="Nicolas_upshifts" /id="D1158" /incds=0 /nref=4 /ntot=78 /MaxReadThrough="1.34397" /MaxDrop="3.87399" /score="12.6922524" /energy="-13.3" /TU="NA" /idTUdmin="U1735" /TUdmin="-5588" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1855582..1855601) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1855598) /Source="Nicolas_upshifts" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1855615..1855622) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1855668..1856660) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 9846747; Product type t: transporter" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate permease" /protein_id="NP_390091.1" /db_xref="EnsemblGenomes-Gn:BSU22090" /db_xref="EnsemblGenomes-Tr:CAB14126" /db_xref="GOA:P50847" /db_xref="InterPro:IPR004684" /db_xref="InterPro:IPR018395" /db_xref="SubtiList:BG11399" /db_xref="UniProtKB/Swiss-Prot:P50847" /translation="MKIKATIERVPGGMMIIPLFLGAALNTFAPGTAEFFGGFTGALI TGTLPILGVFIFCVGATIDFRSSGYIARKGITLLLGKIGFAALLGVIAAQFIPDDGIQ SGFFAGLSVLAIVAVMNETNGGLYLALMNHMGRKEDAGAFAFISTESGPFMTMVTFGV TGLAAFPWETLAATVIPFLLGCILGNLDHDLRDLFSKVVPAIIPFFAFSLGNTLNFGM LIQSGLLGIFIGVSVVILSGSSLFLLDRFIARGDGVAGVAASSTAGAAVAVPYALAEA NASFAPVAESATAIIATSVIVTSLLTPLATVWVDKKIKQKKRRTPPPKNQMTIN*" /label="kdgT CDS" gene complement(1855668..1856660) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /label="kdgT gene" downshifts complement(1855686) /Source="Nicolas_upshifts" /id="D1159" /incds=0 /nref=15 /ntot=59 /MaxReadThrough="3.32882" /MaxDrop="5.85236" /score="36.5247418" /energy="-19.2" /TU="NA" /idTUdmin="U1734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1856705..1857295) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /EC_number="4.1.2.14" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate-6-phosphate aldolase" /protein_id="NP_390092.1" /db_xref="EnsemblGenomes-Gn:BSU22100" /db_xref="EnsemblGenomes-Tr:CAB14127" /db_xref="GOA:P50846" /db_xref="InterPro:IPR000887" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031338" /db_xref="SubtiList:BG11396" /db_xref="UniProtKB/Swiss-Prot:P50846" /translation="MESKVVENRLKEAKLIAVIRSKDKQEACQQIESLLDKGIRAVEV TYTTPGASDIIESFRNREDILIGAGTVISAQQAGEAAKAGAQFIVSPGFSADLAEHLS FVKTHYIPGVLTPSEIMEALTFGFTTLKLFPSGVFGIPFMKNLAGPFPQVTFIPTGGI HPSEVPDWLRAGAGAVGVGSQLGSCSKEDLQAVFQV*" /label="kdgA CDS" gene complement(1856705..1857295) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /label="kdgA gene" CDS complement(1857297..1858271) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /EC_number="2.7.1.45" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143, 15039578; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate kinase" /protein_id="NP_390093.1" /db_xref="EnsemblGenomes-Gn:BSU22110" /db_xref="EnsemblGenomes-Tr:CAB14128" /db_xref="GOA:P50845" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG11397" /db_xref="UniProtKB/Swiss-Prot:P50845" /translation="MKLDAVTFGESMAMFYANEYGGLHEVSTFSKGLAGAESNVACGL ARLGFRMGWMSKVGNDQLGTFILQELKKEGVDVSRVIRSQDENPTGLLLKSKVKEGDP QVTYYRKNSAASTLTTAEYPRDYFQCAGHLHVTGIPPALSAEMKDFTYHVMNDMRNAG KTISFDPNVRPSLWPDQATMVHTINDLAGLADWFFPGIAEGELLTGEKTPEGIADYYL KKGASFVAIKLGKEGAYFKTGTSEGFLEGCRVDRVVDTVGAGDGFAVGVISGILDGLS YKDAVQRGNAIGALQVQAPGDMDGLPTREKLASFLSAQRTVHQKKGDY*" /label="kdgK CDS" gene complement(1857297..1858271) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /label="kdgK gene" CDS complement(1858309..1859328) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9846747, 15223311, 17322190, 28040177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9846747, 15223311, 17322190, 28040177; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the Kdg operon (KdgR-galacturonate)" /protein_id="NP_390094.1" /db_xref="EnsemblGenomes-Gn:BSU22120" /db_xref="EnsemblGenomes-Tr:CAB14129" /db_xref="GOA:P50844" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG11398" /db_xref="UniProtKB/Swiss-Prot:P50844" /translation="MKKKTTGHTTIKDVAECAGVSKSTVSRYINGKIDAISPEKVKNI KKAIAELNYRPSKMAQGLKIKKSKLIGFVVADITNPFSVAAFRGVEEVCDQYGYSIMV CNTDNSPEKEREMLLKLEAHSVEGLILNATGENKDVLRAFAEQQIPTILIDRKLPDLK LDTVTTDNRWITKEILQKVYSKGYTDVALFTEPISSISPRAERAAVYQEMASVQNVNG LVRLHEIDVKDKEQLKAELRSFHKEMPEQKKAILALNGLIMLKIISCMEELGLRIPQD IGIAGFDDTEWYKLIGPGITTIAQPSHDMGRTAMERVLKRIEGDKGAPQTIELEAKVI MRKSL*" /label="kdgR CDS" gene complement(1858309..1859328) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /label="kdgR gene" promotor_-10 complement(1859376..1859395) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1859386) /Source="Nicolas_upshifts" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1859407..1859414) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1859449..1859456 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1859470..1859549 /Source="Nicolas_S_feature" /locus_tag="new_2325774_2325853" /HighExp="HiTm, Heat, nit, LBGstat, ferm, T-0.40H, HiOs, T1.30H, MG 150, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S836" upshifts 1859470 /Source="Nicolas_upshifts" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1859471..1859490 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1859550..1860377 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /EC_number="5.3.1.17" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 23437267, 27227414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase" /protein_id="NP_390095.1" /db_xref="EnsemblGenomes-Gn:BSU22130" /db_xref="EnsemblGenomes-Tr:CAB14130" /db_xref="GOA:P50843" /db_xref="InterPro:IPR007045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR027449" /db_xref="SubtiList:BG11401" /db_xref="UniProtKB/Swiss-Prot:P50843" /translation="MENRYSVHPEQVKRFTTEELRSHFLMDSLFTENKLTMYYSHEDR VVIGGAAPGQSELKLDAGDFLKTDFFLERREIGIINVGQPGAVRVGDDEYVLQTKDFL YIGMGNQDVSFSSLNGEKAKFYFVSACAHKSYPTQKAALSELTPDRLGDDAASNVRSL YKVIHQDGIKSCQLMMGITMLDQNNNWNTMPAHVHDRRMEAYLYLDLEKDSKVFHFMG QPDETRHLVVGNEQAVLSPAWSIHSGAGTSNYSFVWAMAGENYTFTDMDLIPMDGLK* " /label="kduI CDS" gene 1859550..1860377 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /label="kduI gene" CDS 1860379..1861143 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /EC_number="1.1.1.127" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 24509771, 27028675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate oxidoreductase" /protein_id="NP_390096.1" /db_xref="EnsemblGenomes-Gn:BSU22140" /db_xref="EnsemblGenomes-Tr:CAB14131" /db_xref="GOA:P50842" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011286" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11400" /db_xref="UniProtKB/Swiss-Prot:P50842" /translation="MGYLHDAFSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSH TSSLSETQQLVEQEGRIFTSFTLDMSKPEAIKDSAAELFENRQIDILVNNAGIIHREK AEDFPEENWQHVLNVNLNSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYT ASKHAVAGLTKSFANEWAASGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGR WGQADDIGGTAVFLASRASDYVNGHILAVDGGWLSR*" /label="kduD CDS" gene 1860379..1861143 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /label="kduD gene" downshifts 1861132 /Source="Nicolas_upshifts" /id="D1160" /incds=0 /nref=12 /ntot=160 /MaxReadThrough="0.66029" /MaxDrop="3.56178" /score="23.0070487" /energy="-12.3" /TU="NA" /idTUdmin="U1735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1861174) /Source="Nicolas_upshifts" /id="D1161" /incds=0 /nref=28 /ntot=225 /MaxReadThrough="1.88107" /MaxDrop="5.27501" /score="35.5168663" /energy="-12.3" /TU="NA" /idTUdmin="U1736" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(1861184..1863109) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /EC_number="3.6.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8385320, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent helicase" /protein_id="NP_390097.1" /db_xref="EnsemblGenomes-Gn:BSU22150" /db_xref="EnsemblGenomes-Tr:CAB14132" /db_xref="GOA:P50831" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11457" /db_xref="UniProtKB/Swiss-Prot:P50831" /translation="MTTSRLPFSLTKTKNFYEELNNWIGDVFYDILPEKGFDLRDEQV FMAFQLERAFKEKKVMFAEAGVGTGKTLVYLLFAISYARYVGKPAIIACADETLIEQL VKKEGDISKLAEHLDLKIDTRLSKSHEQYLCLKKLEKTMQRSDDDKWLDLYESLPSFV HESQAMQRFYPYGDRKQYANLSNEEWSDVSYDSFQDCLTCDMRHRCGLTLSRDYYRKS TDLIICSHDFYMEHVWTEESRKREGQLPLLPDHSAVVFDEGHLLEFAAQKALTYRVKQ STLELFLERLLQNDIREEFAELIEDALLANDEFFYVLSEESKEVAGSHRLEIKNDHRV KKAADELCRLLDKIGEALVFESEMYTIDQYELSVVEEYVEQMAYSLSLYQKDAISWLE KKEAESTFVVMPRTVAEVLGEKVFSKKIPYIFSSATLSEGGSFDYIADSLGIHDYLSL TVDSPYDYDEQMSINLYAKTDMDAEQKTAETIETIKRYKGRTLVLFPSFEELNEFKEL SAAWELPYPIFFEGDEEISSLVEKFQEEEETVLCSVHLWEGLDIPGDALKNVTIWSLP FPPHDPVFTAKRNGAKKDPFEEVDLPYMLLRVRQGIGRLIRSNQDSGSIHIYAGGENE RIIDEVKKVLPVEPHMM*" /label="ypvA CDS" gene complement(1861184..1863109) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /label="ypvA gene" promotor_-10 complement(1863140..1863159) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1863144) /Source="Nicolas_upshifts" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1863146..1863210) /Source="Nicolas_S_feature" /locus_tag="new_2329450_2329514_c" /HighExp="S3, S4, S8, S7, LoTm, S5, S6, BT, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S837" promotor_-35 complement(1863174..1863178) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1863211..1863402) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390098.1" /db_xref="EnsemblGenomes-Gn:BSU22160" /db_xref="EnsemblGenomes-Tr:CAB14133" /db_xref="SubtiList:BG11456" /db_xref="UniProtKB/Swiss-Prot:P50841" /translation="MLNSEHFNLIQRALDATANELKELGTDSSPSVISHAQTDLEKAV EHIYSTDHPFLSSHVINRK*" /label="yptA CDS" gene complement(1863211..1863402) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /label="yptA gene" promotor_-10 complement(1863421..1863439) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1863430) /Source="Nicolas_upshifts" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1863432..1863737) /Source="Nicolas_S_feature" /locus_tag="new_2329736_2330041_c" /HighExp="Cold, G135, G180, C30, G150, Oxctl, Paraq, H2O2, LBGstat, LPh" /AntisenseName="ypzG" /AntisenseCor="-0.39420155633160697" /AntisenseRegPval="-10.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S838" promotor_-35 complement(1863455..1863460) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1863469..1863475 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1863490..1863501 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1863499 /Source="Nicolas_upshifts" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="upshifts" CDS 1863566..1863718 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097754.1" /db_xref="EnsemblGenomes-Gn:BSU22169" /db_xref="EnsemblGenomes-Tr:CAX52653" /db_xref="InterPro:IPR025413" /db_xref="UniProtKB/Swiss-Prot:C0H444" /translation="MSYRNRLDQHSELFHHNWTRPKRSKSQVNGHTEMSQTNIILRSN AKAHRW*" /label="ypzG CDS" gene 1863566..1863718 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /label="ypzG gene" downshifts 1863728 /Source="Nicolas_upshifts" /id="D1162" /incds=0 /nref=35 /ntot=65 /MaxReadThrough="1.2837" /MaxDrop="7.64655" /score="-9.36260071" /energy="-16.3" /TU="NA" /idTUdmin="U1738" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1863771..1864928) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /EC_number="2.1.1.264" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22210896, 22362734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="m(7)G2069 methylase of 23S rRNA" /protein_id="NP_390099.1" /db_xref="EnsemblGenomes-Gn:BSU22170" /db_xref="EnsemblGenomes-Tr:CAB14134" /db_xref="GOA:P50840" /db_xref="InterPro:IPR000241" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11455" /db_xref="UniProtKB/Swiss-Prot:P50840" /translation="MKKYTLIATAPMGIEAVVAKEVRDLGYECKVDNGKVIFEGDALA ICRANLWLRTADRIKVQVASFKAKTFDELFEKTKAINWRSFIPENGKFPVIGKSVKST LASVPDCQRIVKKAIVEKLKLQSGKANDWIEETGAEYKVEISLLKDQALITLDSSGTG LHKRGYRVDQGGAPIKETLAAALVQLTNWTPDRPFVDPFCGSGTIAIEAALIGQNIAP GFNRDFVSEDWEWIGKDLWNKARLEVEEKANYDQPLTIFASDIDHRMVQIAKENAEEA GLGDLIQFKQMQVKDFTTNLEFGVIVGNPPYGERLGEKKAVEQMYKEMGQAFEPLDTW SVYMLTSNENFEEAYGRKATKKRKLFNGFIKTDYYQYWSKVRPQRKKTENA*" /label="rlmKB CDS" gene complement(1863771..1864928) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /label="rlmKB gene" downshifts complement(1863782) /Source="Nicolas_upshifts" /id="D1163" /incds=0 /nref=86 /ntot=240 /MaxReadThrough="4.31441" /MaxDrop="4.58268" /score="14.6684819" /energy="-6.2" /TU="U1739" /idTUdmin="U1740" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(1865016..1865416) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /product="RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)" /experiment="publication(s) with functional evidences, PMID:1699929, 16980484, 17919279, 22448220" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1699929, 16980484, 17919279, 22448220; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rnpB RNA" gene complement(1865016..1865416) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /label="rnpB gene" downshifts complement(1865026) /Source="Nicolas_upshifts" /id="D1164" /incds=0 /nref=200 /ntot=276 /MaxReadThrough="6.17541" /MaxDrop="7.4677" /score="0.20729905" /energy="-10.4" /TU="U1739,U1740" /idTUdmin="U1742" /TUdmin=406 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1865413..1865432) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1865431) /Source="Nicolas_upshifts" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1865447..1865453) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1865475..1865771) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:18363795, 18776011, 19429628, 25845974, 27257764" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18363795, 18776011, 19429628, 25845974, 27257764; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell division protein" /protein_id="NP_390100.1" /db_xref="EnsemblGenomes-Gn:BSU22180" /db_xref="EnsemblGenomes-Tr:CAB14135" /db_xref="GOA:P0CI74" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR011229" /db_xref="InterPro:IPR019933" /db_xref="PDB:4UG3" /db_xref="PDB:5AN5" /db_xref="SubtiList:BG11454" /db_xref="UniProtKB/Swiss-Prot:P0CI74" /translation="MLADKVKLSAKEILEKEFKTGVRGYKQEDVDKFLDMIIKDYETF HQEIEELQQENLQLKKQLEEASKKQPVQSNTTNFDILKRLSNLEKHVFGSKLYD*" /label="gpsB CDS" gene complement(1865475..1865771) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /label="gpsB gene" promotor_-10 complement(1865796..1865815) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1865806) /Source="Nicolas_upshifts" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1865829..1865836) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1865849..1866478) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390101.2" /db_xref="EnsemblGenomes-Gn:BSU22190" /db_xref="EnsemblGenomes-Tr:CAB14136" /db_xref="InterPro:IPR010697" /db_xref="PDB:2NX2" /db_xref="SubtiList:BG11453" /db_xref="UniProtKB/Swiss-Prot:P50838" /translation="MENVQLDGVNNAAQQMGPTGAPFFKAGEMMKVLAITGYKPFELG IFKQDDKALYYIKKAIKNRLIAFLDEGLEWILISGQLGVELWAAEAAYDLQEEYPDLK VAVITPFYEQEKNWKEPNKEQYEAVLAQADYEASLTHRPYESPLQFKQKNQFFIDKSD GLLLLYDPEKEGSPKYMLGTAEKRREQDGYPIYFITMDDLRVTVEEDSY*" /label="ypsA CDS" gene complement(1865849..1866478) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /label="ypsA gene" downshifts complement(1866444) /Source="Nicolas_upshifts" /id="D1165" /incds=0 /nref=37 /ntot=160 /MaxReadThrough="5.74028" /MaxDrop="8.12374" /score="7.18626302" /energy="-9.8" /TU="U1741,U1742" /idTUdmin="U1744" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1866480..1866707) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2821284, 10075739, 10400595, 1518043, 1691789, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2821284, 10075739, 10400595, 1518043, 1691789, 19933362; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner)" /protein_id="NP_390102.1" /db_xref="EnsemblGenomes-Gn:BSU22200" /db_xref="EnsemblGenomes-Tr:CAB14137" /db_xref="GOA:P07791" /db_xref="InterPro:IPR020108" /db_xref="SubtiList:BG10493" /db_xref="UniProtKB/Swiss-Prot:P07791" /translation="MHHCRPHMMAPIVHPTHCCEHHTFSKTIVPHIHPQHTTNVNHQH FQHVHYFPHTFSNVDPATHQHFQAGKPCCDY*" /label="cotD CDS" gene complement(1866480..1866707) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /label="cotD gene" promotor_-10 complement(1866735..1866754) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-10" upshifts complement(1866750) /Source="Nicolas_upshifts" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="upshifts" S_feature complement(1866752..1866906) /Source="Nicolas_S_feature" /locus_tag="new_2333056_2333210_c" /HighExp="LBGexp, dia15, Paraq, H2O2, Heat, G135, UNK1, Lbexp, BMM, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.808141" /TUshortSig="SigA, Sig-, SigA, SigA" /TUshortPSig="1, 0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S839" promotor_-35 complement(1866768..1866776) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-35" CDS complement(1866791..1866919) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513975.1" /translation="MTLVIFKGRVGMYKGVFYLFFVVVFLIAFVFSNFKDSLIAHF*" /label="conserved protein of unknown function CDS" gene complement(1866791..1866919) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /label="gene" upshifts complement(1866906) /Source="Nicolas_upshifts" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" S_feature complement(1866908..1867019) /Source="Nicolas_S_feature" /locus_tag="new_2333212_2333323_c" /HighExp="Sw, M40t90, Etha, Salt, M40t45, H2O2, S8, S6, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S840" promotor_-10 complement(1866909..1866928) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" promotor_-35 complement(1866944..1866948) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1867020..1868261) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23249255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding enzyme" /protein_id="NP_390103.1" /db_xref="EnsemblGenomes-Gn:BSU22210" /db_xref="EnsemblGenomes-Tr:CAB14138" /db_xref="GOA:P50837" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11452" /db_xref="UniProtKB/Swiss-Prot:P50837" /translation="MSLKGKLQRMKKHMALDEGEQKIEAGKQENHFDDIPFLEEWEAF GMKPFIFEDEYCLIREVEYPLSHRHGLYSFSELEEVITLWNQSGLSHTLSAKGYNKNN LFFFDTETTGLGGGAGNTIFLLGHARVYEDRVTVKQHLLPKPGNEVALYQSFLSEVDI TSLVTYNGKAFDWPQVKTRHTLIRDRLPKLPEFGHFDLLHGARRLWKHKMDRVSLGTV EKEELGIRRLEDTPGYLAPMLYFHFIKAQEPDLLKGVLHHNEMDVLSLISLYIHMSKK ILSESHAPKEHSEAYAMAKWFMAHKETDQAIKQLERLIEKSFEDQDSARLDLSLLYKK QNRLEEAVPLWEKLSRSQNQKCRYAAVIELAKYFEHKKKEFGKALQVAEQSLSDAACL SEKETEKLHVRIARLKRKYSS*" /label="yprB CDS" gene complement(1867020..1868261) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /label="yprB gene" promotor_-10 complement(1867975..1867993) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-10" upshifts complement(1867984) /Source="Nicolas_upshifts" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="upshifts" promotor_-35 complement(1868008..1868015) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-35" CDS complement(1868277..1870526) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /EC_number="3.6.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_390104.1" /db_xref="EnsemblGenomes-Gn:BSU22220" /db_xref="EnsemblGenomes-Tr:CAB14139" /db_xref="GOA:P50830" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018973" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11451" /db_xref="UniProtKB/Swiss-Prot:P50830" /translation="MKKKSLTELISDLKGNENVVNWHEIEPREAKTRPMPESIDERIK AALSKRGIDELYTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIAQDETNRA LYLFPTKALAQDQKSELNEIIDEMGIDIKSFTYDGDTSPAIRQKVRKAGHIVITNPDM LHSAILPHHTKWVSLFENLKYIVIDELHTYRGVFGSHVANVIRRLKRICRFYGSDPVF ICTSATIANPKELGEQLTGKPMRLVDDNGAPSGRKHFVFYNPPIVNKPLNIRRSATAE VNELAKEFLKNKVQTIVFARSRVRVEIILSHIQELVKKEIGTKSIRGYRGGYLPKERR EIERGLREGDILGVVSTNALELGVDIGQLQVCVMTGYPGSVASAWQQAGRAGRRHGES LIIMVANSTPIDQYIVRHPEYFFNRSPESARINPENLIILVDHLKCAAYELPFRADEE FGAMEVSDILEYLQEEAVLHRNGERYHWASESFPASNISLRSASQENVVIVDQSDIAN VRIIGEMDRFSAMTLLHDEAIYLHEGVQYQVEKLDWDHKKAYVRKVDVEYYTDANLAV QLKVLEIDKTKEKSRTSLHYGDVTVNALPTIFKKIKMTTFENIGSGPIHLPEEELHTS AAWLEIKTADEDIGEKTLEQLLLGISNVLQHIVPVYIMCDRNDVHVVSQIKAAHTGLP TIFLYDHYPGGIGLAEEVFKRFSDINEAAKQLITHCPCHDGCPSCIGTEIEGIKAKER ILQLLDQMS*" /label="yprA CDS" gene complement(1868277..1870526) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /label="yprA gene" promotor_-10 complement(1870542..1870561) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1870558) /Source="Nicolas_upshifts" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1870575..1870581) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1870629..1871135) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10627040, 28731580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase system enzyme IIA component" /protein_id="NP_390105.1" /db_xref="EnsemblGenomes-Gn:BSU22230" /db_xref="EnsemblGenomes-Tr:CAB14140" /db_xref="GOA:P50829" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG11450" /db_xref="UniProtKB/Swiss-Prot:P50829" /translation="MLKKLFGMGKIQEKVTEEVIYSPADGTVMDLSDVPDPVFSQKMM GEGIAVEPSSGEIVSPAEGEVIQIFHTKHAVGIRTRSGIELLIHVGLETVNMNGEGFT AHIKEGDKVKVGDPLITCDLELIKEKASSTVIPIVIMNGEAVGSMVSAGEKAARKGES KLFTIKAK*" /label="ypqE CDS" gene complement(1870629..1871135) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /label="ypqE gene" downshifts complement(1870652) /Source="Nicolas_upshifts" /id="D1166" /incds=0 /nref=88 /ntot=236 /MaxReadThrough="4.55156" /MaxDrop="6.1724" /score="32.5355561" /energy="-10.2" /TU="U1745" /idTUdmin="U1747" /TUdmin=808 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1871179..1871198) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1871196) /Source="Nicolas_upshifts" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1871212..1871219) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" promotor_-35 1871217..1871226 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1871240..1871259 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1871252 /Source="Nicolas_upshifts" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="upshifts" CDS 1871273..1871692 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_390106.1" /db_xref="EnsemblGenomes-Gn:BSU22240" /db_xref="EnsemblGenomes-Tr:CAB14141" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11449" /db_xref="UniProtKB/Swiss-Prot:P50836" /translation="MEFHDDKKNELQKKEEIITEAIDTLFQSSAFGNLINGFQNLINS SLKDVQTTIHVRERDTGLYIDITIPATFRDGEIVVDVKSRYLHVTLQEKQKHQNEATF TSMTRTVQLPYEVRQEDMETSWNEQTMTLFFPKNKHE*" /label="ypqA CDS" gene 1871273..1871692 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /label="ypqA gene" S_feature 1871693..1871843 /Source="Nicolas_S_feature" /locus_tag="new_2337997_2338147" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, nit" /AntisenseName="yppG" /AntisenseCor="0.95679380325708796" /AntisenseRegPval="-144.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S841" CDS complement(1871713..1872090) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein; methionine-glutamine-rich protein" /protein_id="NP_390107.1" /db_xref="EnsemblGenomes-Gn:BSU22250" /db_xref="EnsemblGenomes-Tr:CAB14142" /db_xref="InterPro:IPR025555" /db_xref="SubtiList:BG11448" /db_xref="UniProtKB/Swiss-Prot:P50835" /translation="MNGSSRSYPRQMGYYYPQHMQGYYQQAAPGYLEQQLPQQHYGQQ DYYQPYAPIQPMPMQPPVFSNPYPIPRPNQQQPSQFQSIMSQFKKANGQFDFNKMMDT TGQVMSAMNQVGSLIKGFTSFFK*" /label="yppG CDS" gene complement(1871713..1872090) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /label="yppG gene" downshifts complement(1871746) /Source="Nicolas_upshifts" /id="D1167" /incds=0 /nref=10 /ntot=43 /MaxReadThrough="3.01854" /MaxDrop="4.7006" /score="0.85617333" /energy="-12.8" /TU="U1747" /idTUdmin="U1747" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature 1872088..1872233 /Source="Nicolas_S_feature" /locus_tag="new_2338392_2338537" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, C30" /AntisenseName="yppG" /AntisenseCor="0.96504903995490698" /AntisenseRegPval="-156.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S842" promotor_-10 complement(1872120..1872138) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1872139) /Source="Nicolas_upshifts" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1872152..1872161) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1872234..1872253 /Source="Nicolas_upshift_promotors" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1872235 /Source="Nicolas_upshifts" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1872278..1872466 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390108.1" /db_xref="EnsemblGenomes-Gn:BSU22260" /db_xref="EnsemblGenomes-Tr:CAB14143" /db_xref="InterPro:IPR025553" /db_xref="SubtiList:BG11447" /db_xref="UniProtKB/Swiss-Prot:P50834" /translation="MNVSYLSKRFAEMKKYETDCMNKLMDFAKFLYIQGHLSITEFRN SMKVLEANGAESPAYEMN*" /label="yppF CDS" gene 1872278..1872466 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /label="yppF gene" downshifts 1872482 /Source="Nicolas_upshifts" /id="D1168" /incds=0 /nref=112 /ntot=242 /MaxReadThrough="3.3677" /MaxDrop="5.69944" /score="0.283992322" /energy="-8.5" /TU="U1748" /idTUdmin="U1748" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" CDS complement(1872505..1872876) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390109.1" /db_xref="EnsemblGenomes-Gn:BSU22270" /db_xref="EnsemblGenomes-Tr:CAB14144" /db_xref="InterPro:IPR014913" /db_xref="InterPro:IPR023351" /db_xref="PDB:2HFI" /db_xref="PDB:2IM8" /db_xref="SubtiList:BG11446" /db_xref="UniProtKB/Swiss-Prot:P50833" /translation="MLSQTLLEMTEQMIEVAEKGADRYQEGKNSNHSYDFFETIKPAV EENDELAARWAEGALELIKVRRPKYVHKEQIEAVKDNFLELVLQSYVHHIHKKRFKDI TESVLYTLHAVKDEIAREDSR*" /label="yppE CDS" gene complement(1872505..1872876) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /label="yppE gene" downshifts complement(1872538) /Source="Nicolas_upshifts" /id="D1169" /incds=0 /nref=158 /ntot=245 /MaxReadThrough="1.04225" /MaxDrop="5.78413" /score="-2.77698308" /energy="-10.3" /TU="NA" /idTUdmin="U1749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1872888..1872907) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1872901) /Source="Nicolas_upshifts" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1872920..1872925) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1872922..1873167) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15687200; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390110.1" /db_xref="EnsemblGenomes-Gn:BSU22280" /db_xref="EnsemblGenomes-Tr:CAB14145" /db_xref="InterPro:IPR020252" /db_xref="SubtiList:BG11445" /db_xref="UniProtKB/Swiss-Prot:P50832" /translation="MSGYVCKTDILRMLSDIEDELTRAEQSLNHSVNALEAEMRETEN DRLSVLEEEIIDLHICINELYQSPEHRYAFEKVYRIG*" /label="yppD CDS" gene complement(1872922..1873167) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /label="yppD gene" promotor_-10 complement(1873193..1873211) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1873198) /Source="Nicolas_upshifts" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1873223..1873231) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1873317..1873323 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1873338..1873349 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1873345 /Source="Nicolas_upshifts" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="upshifts" CDS 1873366..1873470 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054585.1" /db_xref="EnsemblGenomes-Gn:BSU22290" /db_xref="EnsemblGenomes-Tr:CAE01459" /db_xref="GOA:Q7WY65" /db_xref="SubtiList:BG14177" /db_xref="UniProtKB/Swiss-Prot:Q7WY65" /translation="MKTRPKKAGQQKKTESKAIDSLDKKLGGPNRPST*" /label="sspM CDS" gene 1873366..1873470 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /label="sspM gene" downshifts 1873452 /Source="Nicolas_upshifts" /id="D1170" /incds=0 /nref=31 /ntot=49 /MaxReadThrough="1.6498" /MaxDrop="6.01285" /score="0.283992322" /energy="-8.5" /TU="NA" /idTUdmin="U1751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1873495..1874457) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390111.1" /db_xref="EnsemblGenomes-Gn:BSU22300" /db_xref="EnsemblGenomes-Tr:CAB14146" /db_xref="InterPro:IPR019658" /db_xref="SubtiList:BG10952" /db_xref="UniProtKB/Swiss-Prot:P39791" /translation="MNVQEQQAIRKLLSRIERQTKMKNADNISRTNAYKAFYDRHPEI KWSLLASFVSRNAGWSMTDLKGSLFQLGLRERQQKWFFLAYERANWLIFSDAYPQLLL YHWSKRVGKPLFHLLHVFGVSQFMSEEWTRFWHERNTERLMYALIINEQNTIQTPIIQ NPSFKKNVFDTIPFYLSDWFHFNTVIFPSSNGFFYGISVKRFSKAEERIRLGKQLSQL LFKPELFSSFYHFLHTVPHTGSRFDMEKMIGITKRTSPMLRTCYPELIHSLDGTKTDW FHGKIKKTFFRREELPKQIELTDWYLHKKRQLHALFAVEQWLKK*" /label="yppC CDS" gene complement(1873495..1874457) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /label="yppC gene" promotor_-35 1873625..1873634 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1873646..1873661 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1873646 /Source="Nicolas_upshifts" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1873650..1873985 /Source="Nicolas_S_feature" /locus_tag="new_2339954_2340289" /HighExp="T1.0H, T0.30H, T1.30H, H2O2, Paraq, LBGstat, T2.0H, T-0.40H, Salt, T2.30H" /AntisenseName="yppC" /AntisenseCor="-0.27690969451148201" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S843" promotor_-35 1873956..1873960 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1873976..1873995 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1873987..1874497 /Source="Nicolas_S_feature" /locus_tag="new_2340291_2340801" /HighExp="LBGstat, T1.0H, T1.30H, H2O2, T0.30H, Paraq, T2.0H, C30, G135, G180" /AntisenseName="yppC" /AntisenseCor="-0.312791370178301" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S844" upshifts 1873987 /Source="Nicolas_upshifts" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1874458..1874914) /Source="Nicolas_S_feature" /locus_tag="new_2340762_2341218_c" /HighExp="S8, S6, S7, S5, C30, G135, S4, BT, G180, Fru" /AntisenseName="recU" /AntisenseCor="-0.34780203121991599" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S845" CDS 1874498..1875118 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction resolvase" /protein_id="NP_390112.1" /db_xref="EnsemblGenomes-Gn:BSU22310" /db_xref="EnsemblGenomes-Tr:CAB14147" /db_xref="GOA:P39792" /db_xref="InterPro:IPR004612" /db_xref="InterPro:IPR011335" /db_xref="PDB:1RZN" /db_xref="PDB:1ZP7" /db_xref="PDB:5FDK" /db_xref="SubtiList:BG10953" /db_xref="UniProtKB/Swiss-Prot:P39792" /translation="MIRYPNGKTFQPKHSVSSQNSQKRAPSYSNRGMTLEDDLNETNK YYLTNQIAVIHKKPTPVQIVNVHYPKRSAAVIKEAYFKQSSTTDYNGIYKGRYIDFEA KETKNKTSFPLQNFHDHQIEHMKQVKAQDGICFVIISAFDQVYFLEADKLFYFWDRKE KNGRKSIRKDELEETAYPISLGYAPRIDYISIIEQLYFSPSSGAKG*" /label="recU CDS" gene 1874498..1875118 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /label="recU gene" promotor_-10 complement(1874903..1874914) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1874914) /Source="Nicolas_upshifts" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1874929..1874935) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1875140..1877884 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /EC_number="2.4.1.129" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan glycosyltransferase (penicillin-binding proteins 1A and 1B)" /protein_id="NP_390113.1" /db_xref="EnsemblGenomes-Gn:BSU22320" /db_xref="EnsemblGenomes-Tr:CAB14148" /db_xref="GOA:P39793" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR003961" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036116" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10954" /db_xref="UniProtKB/Swiss-Prot:P39793" /translation="MSDQFNSREARRKANSKSSPSPKKGKKRKKGGLFKKTLFTLLIL FVLGVVGGAVTFAVMVSDAPSLDESKLKTPYSSTIYDKNGKEIAEVGAEKRTYVSIDE IPDVVKEAFIATEDARFYEHHGIDPVRIGGALVANFKDGFGAEGGSTITQQVVKNSLL SHQKTLKRKVQEVWLSIQLERNYSKDEILEMYLNRIYFSPRAYGIGKAAEEFFGVTDL SKLTVEQAATLAGMPQSPTAYNPVKNPDKAEKRRNIVLSLMKKQGFISDSQYNKAKKV AVKDEGVVSQKEYEKASTNKYSAFVEEVMKEIDEKSDVDPSADGLKIYTTLDTKAQDK LDELMDGDTVGFTEGMQGGVTLLDTKNGEVRAIGAGRNQPVGGFNYATQTKAQPGSTI KPILDYGPVIENKKWSTYEQIDDSAYTYSNGKPIRDWDRKYLGPISMRYALAQSRNIP ALKAFQAVGKDTAVDFANGLGLGLTKDNVTEAYSIGGFGGNDGVSPLTMAGAYSAFGN NGTYNEPHFVKSIEFNDGTKLDLTPKSKSAMSDYTAFMITDMLKTAVKTGTGQLAQVP GVEVAGKTGTTNFDDNEVKRYNIASGGARDSWFVGYTPQYTAAVWTGMGENEAGKKSL SAEEQKVAKRIFAQLIADVDDGSGSFEKPDSVVEATVEKGSNPAKLAGPNTPSDKKLT EYFVKGTAPSTVSKTYEKEEKEETAKLSGLNVKYDKDNQSLTLSWNYDGDATFAVKQS VDGGSYSEIQNSSAKEAVISGVQPGSVYKFEVTAVSDDGKSTASTSYEVPKAEDDEDK KDQQQTDDEKQDDEKTQDDTQTDDSQKDDGQTDQDQTDDSTNDQDKKQDNTNTNPSDN NNQDQSNDNDNDNSNNQDTSDGDSNSGKNDSTGSDTNKNKTDTSNKTQTNSSSIEKTN *" /label="ponA CDS" gene 1875140..1877884 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /label="ponA gene" downshifts complement(1877554) /Source="Nicolas_upshifts" /id="D1171" /incds=1 /nref=1 /ntot=77 /MaxReadThrough="1.95969" /MaxDrop="2.87717" /score="24.9960782" /energy="-11.3" /TU="NA" /idTUdmin="U1755" /TUdmin=418 /isTUend="FALSE" /label="downshifts" downshifts 1877870 /Source="Nicolas_upshifts" /id="D1172" /incds=0 /nref=243 /ntot=302 /MaxReadThrough="1.61976" /MaxDrop="7.42523" /score="24.2831363" /energy="-14.6" /TU="U1753" /idTUdmin="U1752" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1877960..1878454) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390114.1" /db_xref="EnsemblGenomes-Gn:BSU22330" /db_xref="EnsemblGenomes-Tr:CAB14149" /db_xref="SubtiList:BG10955" /db_xref="UniProtKB/Swiss-Prot:P39789" /translation="MTQAKEVLASYEQYLRSLGQKSSSDMKKTLQTNPVYFDFCTELQ GDLPWEDSGKYVPLLFEVWDDIKASLLPVFQTRKSRCDQNEMLKGIVCLLASLHWTAG EPVKSLDWQELREKSYPAKPINWAERVEFILLKPTQYHCFIQLDELITEMKKHFYKYH AMNR*" /label="ypoC CDS" gene complement(1877960..1878454) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /label="ypoC gene" downshifts complement(1877973) /Source="Nicolas_upshifts" /id="D1173" /incds=0 /nref=116 /ntot=222 /MaxReadThrough="2.50883" /MaxDrop="5.43593" /score="29.5358766" /energy="-11.6" /TU="NA" /idTUdmin="U1755" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1878451..1879110) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /EC_number="4.2.99.18" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9808040, 11160880, 12682299, 21954439, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9808040, 11160880, 12682299, 21954439, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease III, apurinic apyrimidic DNA lyase" /protein_id="NP_390115.1" /db_xref="EnsemblGenomes-Gn:BSU22340" /db_xref="EnsemblGenomes-Tr:CAB14150" /db_xref="GOA:P39788" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR004035" /db_xref="InterPro:IPR004036" /db_xref="InterPro:IPR005759" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG10956" /db_xref="UniProtKB/Swiss-Prot:P39788" /translation="MLNLKQIEFCLDKIGDMFPHAECELVHSNPFELVVAVALSAQCT DALVNRVTKTLFQKYKRPEDYLAVPLEELQQDIKSIGLYRNKAKNIQKLSKMIIEDYG GEVPRDRDELVKLPGVGRKTANVVVSVAFGVPAIAVDTHVERVSKRLGICRWKDSVLE VEKTLMRKVPKEDWSVTHHRLIFFGRYHCKAQSPRCAECPLLSLCREGQKRDKKGLVK R*" /label="nth CDS" gene complement(1878451..1879110) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /label="nth gene" CDS complement(1879129..1879827) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /function="16.9: Replicate" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-remodelling primosomal protein" /protein_id="NP_390116.1" /db_xref="EnsemblGenomes-Gn:BSU22350" /db_xref="EnsemblGenomes-Tr:CAB14151" /db_xref="GOA:P39787" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="PDB:2V79" /db_xref="SubtiList:BG10957" /db_xref="UniProtKB/Swiss-Prot:P39787" /translation="MKKQQFIDMQEQGTSTIPNLLLTHYKQLGLNETELILLLKIKMH LEKGSYFPTPNQLQEGMSISVEECTNRLRMFIQKGFLFIEECEDQNGIKFEKYSLQPL WGKLYEYIQLAQNQTQERKAEGEQKSLYTIFEEEFARPLSPLECETLAIWQDQDQHDA QLIKHALKEAVLSGKLSFRYIDRILFEWKKNGLKTVEQAKIHSQKFRRVQAKQNEPQK EYKRQVPFYNWLEQ*" /label="dnaD CDS" gene complement(1879129..1879827) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /label="dnaD gene" S_feature complement(1879828..1879919) /Source="Nicolas_S_feature" /locus_tag="new_2346132_2346223_c" /HighExp="LoTm, G180, Cold, G135, LBGstat, G150, C30, Etha, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S846" CDS complement(1879920..1881212) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /EC_number="6.1.1.22" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparaginyl-tRNA synthetase" /protein_id="NP_390117.1" /db_xref="EnsemblGenomes-Gn:BSU22360" /db_xref="EnsemblGenomes-Tr:CAB14152" /db_xref="GOA:P39772" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004522" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10958" /db_xref="UniProtKB/Swiss-Prot:P39772" /translation="MKTTINQVYKHVGEEVTIGAWVANKRSSGKIAFLQLRDGTGFIQ GVVVKAEVEESIFQTAKSVTQETSLYIKGIVKEDERSPLGYELAVTDIEVIHEATDYP ITPKEHGTEFLMDHRHLWLRSKRQHAIMKIRNEIIRATYEFFNNEGFVKVDPPILTGS APEGTTELFATKYFDEDAYLSQSGQLYMEAAAMALGKVFSFGPTFRAEKSKTKRHLIE FWMIEPEMAFVEFEENLQVQENYVSFIVQSVLKNCKIELNTLGRDTSKLEQIKAPFPR ITYDEAIEFLKEKGFDDIEWGDDFGAPHETAIAEHYDKPVFITRYPTSLKPFYMQPAS DREDVVLCADLIAPEGYGEIIGGSERIHDMELLESRLKEHGLDSDAYKWYAELRKYGS VPHSGFGLGLERTVAWISGAPHVRETIPFPRLLNRLYP*" /label="asnS CDS" gene complement(1879920..1881212) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /label="asnS gene" S_feature complement(1881213..1881274) /Source="Nicolas_S_feature" /locus_tag="new_2347517_2347578_c" /HighExp="LBGexp, dia0, Lbexp, G150, G180, LPh, C30, Oxctl, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S847" promotor_-10 complement(1881274..1881293) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1881274) /Source="Nicolas_upshifts" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1881308..1881315) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1881356..1882537) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /EC_number="2.6.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:418816, 12670965, 22740702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 418816, 12670965, 22740702; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anabolic oxaloacetate / glutamate aminotransferase" /protein_id="NP_390118.1" /db_xref="EnsemblGenomes-Gn:BSU22370" /db_xref="EnsemblGenomes-Tr:CAB14153" /db_xref="GOA:P53001" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11513" /db_xref="UniProtKB/Swiss-Prot:P53001" /translation="MKLAKRVSALTPSTTLAITAKAKELKAAGHDVIGLGAGEPDFNT PQHIIDAAVRSMNEGHTKYTPSGGLAELKNSIAEKFKRDQNIEYKPSQIIVCTGAKHA LYTLFQVILDEEDEVIIPTPYWVSYPEQVKLAGGKPVYVEGLEENHFKISPEQLKNAI TEKTKAIVINSPSNPTGVMYTEEELSALGEVCLEHDILIVSDEIYEKLTYGGKKHVSI AQLSDRLKEQTVIINGVSKSHSMTGWRIGYAAGSEDIIKAMTNLASHSTSNPTSIAQY GAIAAYNGPSEPLEEMREAFEHRLNTIYAKLIEIPGFSCVKPEGAFYLFPNAKEAAQS CGFKDVDEFVKALLEEEKVAIVPGSGFGSPENVRLSYATSLDLLEEAIERIKRFVEKH S*" /label="aspB CDS" gene complement(1881356..1882537) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /label="aspB gene" downshifts complement(1881360) /Source="Nicolas_upshifts" /id="D1174" /incds=0 /nref=48 /ntot=196 /MaxReadThrough="6.37268" /MaxDrop="4.0831" /score="5.04709675" /energy="-9.3" /TU="U1756,U1758,U1760,U1761,U1762" /idTUdmin="U1760" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1882560..1883045) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /experiment="publication(s) with functional evidences, PMID:25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25954268; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="suppressor of tetracyclin sensitivity of an ezrAmutant" /protein_id="NP_390119.1" /db_xref="EnsemblGenomes-Gn:BSU22380" /db_xref="EnsemblGenomes-Tr:CAB14154" /db_xref="GOA:P54396" /db_xref="InterPro:IPR025711" /db_xref="PDB:2GU3" /db_xref="SubtiList:BG11502" /db_xref="UniProtKB/Swiss-Prot:P54396" /translation="MRKKALIFTVIFGIIFLAVLLVSASIYKSAMAQKEEGHEAAAAE AKKETDLAHVDQVETFVGKEKYYVVKGTDKKGTALYVWVPADKKAKILSKEAKEGISE DKAAKIIKDEGLVSKQKEVHLAREGNVLLWEVTYLDKEGQYSLSYVDFTTGKILKNIT P*" /label="tseB CDS" gene complement(1882560..1883045) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /label="tseB gene" promotor_-10 complement(1882993..1883012) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1883010) /Source="Nicolas_upshifts" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1883025..1883032) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1883054..1883224) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390120.1" /db_xref="EnsemblGenomes-Gn:BSU22390" /db_xref="EnsemblGenomes-Tr:CAB14155" /db_xref="InterPro:IPR012190" /db_xref="SubtiList:BG11501" /db_xref="UniProtKB/Swiss-Prot:P54395" /translation="MESKIEILSTINVEHSDDLYKIVDTLNRTLKRDNLMFGLALDEE NKNQAVFTIYRT*" /label="ypmA CDS" gene complement(1883054..1883224) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /label="ypmA gene" S_feature complement(1883225..1883296) /Source="Nicolas_S_feature" /locus_tag="new_2349529_2349600_c" /HighExp="H2O2, T0.30H, T0.0H, dia15, T-0.40H, T-1.10H, G135, T1.0H, G180, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.136042" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.85, 1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S848" promotor_-35 1883258..1883264 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1883279..1883298) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1883279..1883290 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1883286..1883360 /Source="Nicolas_S_feature" /locus_tag="new_2349590_2349664" /HighExp="S8, S6, S5, S7, nit, BT, G/S, Pyr, C30, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S849" upshifts 1883286 /Source="Nicolas_upshifts" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1883296) /Source="Nicolas_upshifts" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1883298..1883366) /Source="Nicolas_S_feature" /locus_tag="new_2349602_2349670_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, Salt, H2O2, T-1.10H, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S850" promotor_-35 complement(1883314..1883320) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1883330 /Source="Nicolas_upshifts" /id="D1175" /incds=0 /nref=8 /ntot=26 /MaxReadThrough="0.48859" /MaxDrop="6.02806" /score="18.4569945" /energy="-8.4" /TU="NA" /idTUdmin="U1757" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1883367..1886162) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8385320, 12060778, 17416902, 21546913, 22166102, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385320, 12060778, 17416902, 21546913, 22166102, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="damage inducible ATP-dependent 3'->5' nuclease" /protein_id="NP_390121.1" /db_xref="EnsemblGenomes-Gn:BSU22400" /db_xref="EnsemblGenomes-Tr:CAB14156" /db_xref="GOA:P54394" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006310" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11515" /db_xref="UniProtKB/Swiss-Prot:P54394" /translation="MNKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKY INPNKSIPAFIEQLTGISNQMVENEQPFEAVAEEVFQLLDGAYFVAHNIHFDLGFVKY ELHKAGFQLPDCEVLDTVELSRIVFPGFEGYKLTELSEELQLRHDQPHRADSDAEVTG LIFLEILEKLRQLPYPTLKQLRRLSQHFISDLTHLLDMFINENRHTEIPGYTRFSSFS VREPEAIDVRINEDENFSFEIESWEAGNEKALSELMPGYEKRDGQMMMMREVADAFAN REHALIEAPPGIGKTIGYLIPAALFAKKSKKPVIISTYSTLLQQQILTKDLPIVQDLF PFPVTAAILKGQSHYLCLYKFEQVLHEEDDNYDAVLTKAQLLVWLTETNTGDVAELNL PSGGKLLWDRLAYDDDSYKRSRSEHVIGFYERAKQIAMRSDLVITNHSLLLTDEGSHK KRLPESGTFIIDEAHHFERAASEHLGKRATYIELHTKLSRIGTLKEQGLLKKMRQLFQ RNSLPVDSFFELEEWLQHVQAESDAFFSSVHSFVKRRKPKEDLNRLVFKVNKESQDKS WSILTDGAERLCSMLTHLQQLFEAQSSLMEKHLKGMKSKTVFLADEYQRSMKGLQHYC QTLQKLFFGSDDDEAVWIEIDAKGAKNAVAIYAQPLEPGELLADQFFARKNSVVLTSA TLTVEGSFQFMIERLGLSDFFPRTMRIESPFSYDERMQVMIPKEMKSIQDTGQPEFIQ DTARYIELMAKEKQPKILVLFTSHDMLKKVHQELKHNMSASGIQLLAQGITGGSPGKL MKTFKTSNQAILLGTNHFWEGVDFPGDELTTVMIVRLPFRSPDHPLHAAKCELARKKG KNPFQTVSLPEAVLTFRQGIGRLLRSAGDKGTIIILDRRIKTAGYGRLFLDALPTTSV SEMTDSELEAYVAGEKE*" /label="dinG CDS" gene complement(1883367..1886162) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /label="dinG gene" promotor_-35 1883835..1883839 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1883836 /Source="Nicolas_upshifts" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1883841..1883845 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1884492..1884507) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1884506) /Source="Nicolas_upshifts" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1884520..1884529) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" S_feature complement(1886163..1886287) /Source="Nicolas_S_feature" /locus_tag="new_2352467_2352591_c" /HighExp="dia15, Diami, H2O2, Heat, LBGstat, C30, G180, G135, Oxctl, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S851" CDS complement(1886288..1886671) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /EC_number="4.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9169598, 12600205, 15033515, 26762040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9169598, 12600205, 15033515, 26762040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate 1-decarboxylase" /protein_id="NP_390122.1" /db_xref="EnsemblGenomes-Gn:BSU22410" /db_xref="EnsemblGenomes-Tr:CAB14157" /db_xref="GOA:P52999" /db_xref="InterPro:IPR003190" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG11493" /db_xref="UniProtKB/Swiss-Prot:P52999" /translation="MYRTMMSGKLHRATVTEANLNYVGSITIDEDLIDAVGMLPNEKV QIVNNNNGARLETYIIPGKRGSGVICLNGAAARLVQEGDKVIIISYKMMSDQEAASHE PKVAVLNDQNKIEQMLGNEPARTIL*" /label="panD CDS" gene complement(1886288..1886671) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /label="panD gene" CDS complement(1886673..1887533) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /EC_number="6.3.2.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17175524, 7037743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate synthetase" /protein_id="NP_390123.1" /db_xref="EnsemblGenomes-Gn:BSU22420" /db_xref="EnsemblGenomes-Tr:CAB14158" /db_xref="GOA:P52998" /db_xref="InterPro:IPR003721" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11520" /db_xref="UniProtKB/Swiss-Prot:P52998" /translation="MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKA RQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGE KNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGL ISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGER DPEAVIKAAKDIIETTSGTIDYVELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNI IIDIREMERI*" /label="panC CDS" gene complement(1886673..1887533) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /label="panC gene" CDS complement(1887535..1888368) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /EC_number="2.1.2.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 8096212; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ketopantoate hydroxymethyltransferase" /protein_id="NP_390124.1" /db_xref="EnsemblGenomes-Gn:BSU22430" /db_xref="EnsemblGenomes-Tr:CAB14159" /db_xref="GOA:P52996" /db_xref="InterPro:IPR003700" /db_xref="InterPro:IPR015813" /db_xref="SubtiList:BG11519" /db_xref="UniProtKB/Swiss-Prot:P52996" /translation="MKTKLDFLKMKESEEPIVMLTAYDYPAAKLAEQAGVDMILVGDS LGMVVLGLDSTVGVTVADMIHHTKAVKRGAPNTFIVTDMPFMSYHLSKEDTLKNAAAI VQESGADALKLEGGEGVFESIRALTLGGIPVVSHLGLTPQSVGVLGGYKVQGKDEQSA KKLIEDSIKCEEAGAMMLVLECVPAELTAKIAETLSIPVIGIGAGVKADGQVLVYHDI IGHGVERTPKFVKQYTRIDETIETAISGYVQDVRHRAFPEQKHSFQMNQTVLDGLYGG K*" /label="panB CDS" gene complement(1887535..1888368) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /label="panB gene" S_feature complement(1888369..1888576) /Source="Nicolas_S_feature" /locus_tag="new_2354673_2354880_c" /HighExp="LBGstat, dia15, Diami, H2O2, MG 15, Heat, Oxctl, MG 25, MG 10, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S852" promotor_-10 complement(1888571..1888590) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1888576) /Source="Nicolas_upshifts" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1888607..1888611) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1888614..1889591) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /EC_number="6.3.4.15" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12368242, 15459338, 28466579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 15459338, 28466579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor (BirA-biotinoyl-5'-AMP)" /protein_id="NP_390125.1" /db_xref="EnsemblGenomes-Gn:BSU22440" /db_xref="EnsemblGenomes-Tr:CAB14160" /db_xref="GOA:P0CI75" /db_xref="InterPro:IPR003142" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004408" /db_xref="InterPro:IPR004409" /db_xref="InterPro:IPR008988" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR030855" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11206" /db_xref="UniProtKB/Swiss-Prot:P0CI75" /translation="MRSTLRKDLIELFSQAGNEFISGQKISDALGCSRTAVWKHIEEL RKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEVMGQHLIYHDVLSSTQKTAHEL ANNNAPEGTLVVADKQTAGRGRMSRVWHSQEGNGVWMSLILRPDIPLQKTPQLTLLAA VAVVQGIEEAAGIQTDIKWPNDILINGKKTVGILTEMQAEEDRVRSVIIGIGINVNQQ PNDFPDELKDIATSLSQAAGEKIDRAGVIQHILLCFEKRYRDYMTHGFTPIKLLWESY ALGIGTNMRARTLNGTFYGKALGIDDEGVLLLETNEGIKKIYSADIELG*" /label="birA CDS" gene complement(1888614..1889591) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /label="birA gene" CDS complement(1889576..1890769) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /EC_number="2.7.7.72" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9829937, 16109934, 20360175, 22940585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829937, 16109934, 20360175, 22940585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA nucleotidyltransferase" /protein_id="NP_390126.1" /db_xref="EnsemblGenomes-Gn:BSU22450" /db_xref="EnsemblGenomes-Tr:CAB14161" /db_xref="GOA:P42977" /db_xref="InterPro:IPR002646" /db_xref="InterPro:IPR023068" /db_xref="InterPro:IPR032810" /db_xref="InterPro:IPR032828" /db_xref="SubtiList:BG11208" /db_xref="UniProtKB/Swiss-Prot:P42977" /translation="MEKVFIKALPVLRILIEAGHQAYFVGGAVRDSYMKRTIGDVDIA TDAAPDQVERLFQRTVDVGKEHGTIIVLWEDETYEVTTFRTESDYVDFRRPSEVQFIS SLEEDLKRRDLTINAMAMTADGKVLDYFGGKKDIDQKVIRTVGKPEDRFQEDALRMLR AVRFMSQLGFTLSPETEEAIAKEKSLLSHVSVERKTIEFEKLLQGRASRQALQTLIQT RLYEELPGFYHKRENLISTSEFPFFSLTSREELWAALLINLGIVLKDAPLFLKAWKLP GKVIKEAIHIADTFGQSLDAMTMYRAGKKALLSAAKISQLRQNEKLDEKKLKDIQYAY QNLPIKSLKDLDITGKDLLALRNRPAGKWVSEELQWIEQAVVTGKLSNQKKHIEEWLK TCGQH*" /label="cca CDS" gene complement(1889576..1890769) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /label="cca gene" CDS complement(1890774..1891907) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /EC_number="2.4.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751541, 20308541, 22569254, 27454321, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751541, 20308541, 22569254, 27454321, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate synthase;malate glycosyltransferase for bacillithiol synthesis" /protein_id="NP_390127.1" /db_xref="EnsemblGenomes-Gn:BSU22460" /db_xref="EnsemblGenomes-Tr:CAB14162" /db_xref="GOA:P42982" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR023881" /db_xref="InterPro:IPR028098" /db_xref="PDB:5D00" /db_xref="PDB:5D01" /db_xref="SubtiList:BG11213" /db_xref="UniProtKB/Swiss-Prot:P42982" /translation="MRKLKIGITCYPSVGGSGIIATELGKQLAEKGHEIHFITSSIPF RLNTYHPNIHFHEVEVNQYAVFKYPPYDLTLASKIAEVAERENLDIIHAHYALPHAVC AYLAKQMLKRNIGIVTTLHGTDITVLGYDPSLKDLIRFAIESSDRVTAVSSALAAETY DLIKPEKKIETIYNFIDERVYLKKNTAAIKEKHGILPDEKVVIHVSNFRKVKRVQDVI RVFRNIAGKTKAKLLLVGDGPEKSTACELIRKYGLEDQVLMLGNQDRVEDLYSISDLK LLLSEKESFGLVLLEAMACGVPCIGTNIGGIPEVIKNNVSGFLVDVGDVTAATARAMS ILEDEQLSNRFTKAAIEMLENEFSSKKIVSQYEQIYADLAEPE*" /label="bshA CDS" gene complement(1890774..1891907) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /label="bshA gene" CDS complement(1891904..1892614) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /EC_number="3.5.1.-" /function="4.10: Glutathione and analogs" /experiment="publication(s) with functional evidences, PMID:11004195, 20308541, 23894131, 28117687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004195, 20308541, 23894131, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1; malate N-acetylglucosamine N-acetyl hydrolase" /protein_id="NP_390128.2" /db_xref="EnsemblGenomes-Gn:BSU22470" /db_xref="EnsemblGenomes-Tr:CAB14163" /db_xref="GOA:P42981" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023842" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG11212" /db_xref="UniProtKB/Swiss-Prot:P42981" /translation="MYNADVLAFGAHSDDVEIGMGGTIAKFVKQEKKVMICDLTEAEL SSNGTVSLRKEEAAEAARILGADKRIQLTLPDRGLIMSDQAIRSIVTVIRICRPKAVF MPYKKDRHPDHGNAAALVEEAIFSAGIHKYKDEKSLPAHKVSKVYYYMINGFHQPDFV IDISDTIEAKKQSLNAYKSQFIPSKDSVSTPLTNGYIEIVEAREKLYGKEAGVEYAEG FFSKRMLMLDHDVLGGEQ*" /label="bshBA CDS" gene complement(1891904..1892614) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /label="bshBA gene" CDS complement(1892607..1893020) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /EC_number="4.2.3.3" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxal synthase" /protein_id="NP_390129.1" /db_xref="EnsemblGenomes-Gn:BSU22480" /db_xref="EnsemblGenomes-Tr:CAB14164" /db_xref="GOA:P42980" /db_xref="InterPro:IPR004363" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR018148" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG11211" /db_xref="UniProtKB/Swiss-Prot:P42980" /translation="MKIALIAHDKKKQDMVQFTTAYRDILKNHDLYATGTTGLKIHEA TGLQIERFQSGPLGGDQQIGALIAANALDLVIFLRDPLTAQPHEPDVSALIRLCDVYS IPLATNMGTAEILVRTLDEGVFEFRDLLRGEEPNV*" /label="mgsA CDS" gene complement(1892607..1893020) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /label="mgsA gene" CDS complement(1893036..1893839) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /EC_number="1.17.1.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6422596, 9398235, 12682299, 20503968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(4S)-4-hydroxy-2,3,4, 5-tetrahydro-(2S)-dipicolinic acid (HTPA) dehydratase reductase" /protein_id="NP_390130.1" /db_xref="EnsemblGenomes-Gn:BSU22490" /db_xref="EnsemblGenomes-Tr:CAB14165" /db_xref="GOA:P42976" /db_xref="InterPro:IPR000846" /db_xref="InterPro:IPR022663" /db_xref="InterPro:IPR022664" /db_xref="InterPro:IPR023940" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11207" /db_xref="UniProtKB/Swiss-Prot:P42976" /translation="MSNETIKLVIAGPRGRMGQEAVKLAERTPHFDLVGAIDHTYDQQ KLSDVMPVESDAFIYTDIHACFTETQPDVLIDLTTPEIGKVHTKIALEHGVRPVVGTT GFSEADLKELTSLTEEKGIGAIIAPNFALGAILMMKFSKMAANYFEDVEIIELHHDQK LDAPSGTALKTAEMISEVRKEKQQGHPDEKEILPGARGAEQNGIRLHSVRLPGLIAHQ EVMFGMDGQTLQIRHDSYNRASFMSGVKLSVEQVMKIDQLVYGLENIID*" /label="dapB CDS" gene complement(1893036..1893839) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /label="dapB gene" CDS complement(1893851..1894186) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16390452, 20529853, 20944217, 21733847, 24339782, 26920050, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidized nucleotide pyrophosphohydrolase" /protein_id="NP_390131.1" /db_xref="EnsemblGenomes-Gn:BSU22500" /db_xref="EnsemblGenomes-Tr:CAB14166" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR012359" /db_xref="PDB:2GTA" /db_xref="SubtiList:BG11210" /db_xref="UniProtKB/Swiss-Prot:P42979" /translation="MSDKTMKDIQAEVDRYIGQFKEGYFSPLAMMARLTEELGELARE VNHRYGEKPKKATEDDKSMEEEIGDVLFVLVCLANSLDISLEEAHDRVMHKFNTRDKD RWTRKEEGK*" /label="ypjD CDS" gene complement(1893851..1894186) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /label="ypjD gene" promotor_-10 complement(1894206..1894225) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1894216) /Source="Nicolas_upshifts" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1894239..1894246) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" promotor_-35 1894255..1894262 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1894271..1894290) /Source="Nicolas_upshift_promotors" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1894276..1894295 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1894282 /Source="Nicolas_upshifts" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1894290) /Source="Nicolas_upshifts" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" CDS 1894326..1895198 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390132.2" /db_xref="EnsemblGenomes-Gn:BSU22510" /db_xref="EnsemblGenomes-Tr:CAB14167" /db_xref="GOA:P42978" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11209" /db_xref="UniProtKB/Swiss-Prot:P42978" /translation="MLGEIRLKNIFFILIGAAIFSFGLVHFNMQNNLAEGGFTGITLL LYALFHISPSISNLVLNIPIFFIGWRLLGRTMFVYTLVGTVALSLFLSIFQRYEIHMP LQHDLALAALFAGVFIGAGLGIIFKFGGTTGGVDIIARLVNKYFGIPMGRTMFAFDAC VIILSLLTYLSYKEAMYTLVAVFVAARLIDFIQEGGYAAKGATIISSKNDLIQKKILE EMERGVTILKGQGSYTKEDIDVLYCVVPKNELVMLKSVINSIDPHAFVAVSDVHDVLG EGFTLDENKNPLPR*" /label="ypjC CDS" gene 1894326..1895198 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /label="ypjC gene" CDS complement(1895240..1896034) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="sporulation septum-associated protein" /protein_id="NP_390133.1" /db_xref="EnsemblGenomes-Gn:BSU22520" /db_xref="EnsemblGenomes-Tr:CAB14168" /db_xref="GOA:P54393" /db_xref="InterPro:IPR014231" /db_xref="SubtiList:BG11500" /db_xref="UniProtKB/Swiss-Prot:P54393" /translation="MKRKLTICLLIALIFYNGNAKAAERGSLEELNDLSDTVFQMTRQ AKYEEALQVLEYFEKTLKSAEKKQQDPMLTGAQIRQITLGYNDMVRSLKQADTSDTQK LRAAAQFRMLMDAVDNRSDPLWGSLEKPIMEAFTELKRDVQKNGSTSFHEKWNEFISL YDLIYPSLTIDVSEDQLETVGKHIDVIEQEEFQQMTESTKLERLSLLQHDLKNVFDRV EEDDADPSLLWVIITTGSIIITALTYVGYRKYKAEKNKLKKRDYPK*" /label="ypjB CDS" gene complement(1895240..1896034) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /label="ypjB gene" downshifts complement(1895265) /Source="Nicolas_upshifts" /id="D1176" /incds=0 /nref=4 /ntot=106 /MaxReadThrough="1.96946" /MaxDrop="3.51024" /score="34.9661402" /energy="-11.3" /TU="NA" /idTUdmin="U1765" /TUdmin=198 /isTUend="FALSE" /label="downshifts" S_feature complement(1896035..1896102) /Source="Nicolas_S_feature" /locus_tag="new_2362339_2362406_c" /HighExp="LBGstat, C30, S0, LoTm, G180, G135, G150, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S853" CDS complement(1896103..1896660) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390134.1" /db_xref="EnsemblGenomes-Gn:BSU22530" /db_xref="EnsemblGenomes-Tr:CAB14169" /db_xref="GOA:P54392" /db_xref="InterPro:IPR009845" /db_xref="SubtiList:BG11499" /db_xref="UniProtKB/Swiss-Prot:P54392" /translation="MLILVLAINFLGTVYGYYWYLPQLLETPARFLIFVPDSPTATFF FLFVLLAFLMKRNAPLLEALALVTLVKYGLWAVAMNFLVLAVTGDLPWEGYMLIASHF AMAVQGVLYSPYFRFSFWHLAIAAVWTLHNDVIDYLFDMMPQYSMLSDYMTEIGYGTF WLSIFSIALAYFLVVSKKQTKLELM*" /label="ypjA CDS" gene complement(1896103..1896660) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /label="ypjA gene" S_feature complement(1896661..1896740) /Source="Nicolas_S_feature" /locus_tag="new_2362965_2363044_c" /HighExp="C30, UNK1, G135, BMM, G150, G180, Oxctl, LoTm, Paraq, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S854" downshifts complement(1896785) /Source="Nicolas_upshifts" /id="D1177" /incds=0 /nref=131 /ntot=215 /MaxReadThrough="3.97061" /MaxDrop="6.41485" /score="13.3880841" /energy="-8" /TU="U1765" /idTUdmin="U1767" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1896807..1897574) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome cc subunit)" /protein_id="NP_390135.1" /db_xref="EnsemblGenomes-Gn:BSU22540" /db_xref="EnsemblGenomes-Tr:CAB14170" /db_xref="GOA:P46913" /db_xref="InterPro:IPR005798" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012049" /db_xref="InterPro:IPR027387" /db_xref="InterPro:IPR036150" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG11327" /db_xref="UniProtKB/Swiss-Prot:P46913" /translation="MHRGKGMKFVGDSRIPAEKKPNIPKDYSEYPGKTEAFWPNFLLK EWMVGAVFLIGFLVLTIVHQPPLERMADPTDTGYIPLPDWYFLFLYQLLKYEYAAGSF TVVGAMIMPGLAFGALLLAPFLDRGTERRPWKRPVAVGMMLLAISAAVFLTWQSVATH DWAKAEEQGKITKEADIDTNAEGYKVFKEQGCISCHGDNLQGGAAGPSLVDSGLKPDE IKKIAVEGKGKMPAGVFKGNDKQLEELAKFISETTAK*" /label="qcrC CDS" gene complement(1896807..1897574) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /label="qcrC gene" CDS complement(1897609..1898283) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 15849754, 16850406; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome b subunit)" /protein_id="NP_390136.1" /db_xref="EnsemblGenomes-Gn:BSU22550" /db_xref="EnsemblGenomes-Tr:CAB14171" /db_xref="GOA:P46912" /db_xref="InterPro:IPR005797" /db_xref="InterPro:IPR016174" /db_xref="InterPro:IPR023530" /db_xref="InterPro:IPR027387" /db_xref="SubtiList:BG11326" /db_xref="UniProtKB/Swiss-Prot:P46912" /translation="MLNKIYDWVDERLDITPMWRDIADHEVPEHVNPAHHFSAFVYCF GGLTFFVTVIQVLSGMFLTMYYVPDIKNAWESVYYLQNEVAFGQIVRGMHHWGASLVI VMMFLHTLRVFFQGAYKKPRELNWIVGVLIFFVMLGLGFTGYLLPWDMKALFATKVGL QIAEATPLIGTQVKTLLAGHPDIVGAQTLTRFFAIHVFFLPAALFGLMAAHFIMIRKQ GISGPL*" /label="qcrB CDS" gene complement(1897609..1898283) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /label="qcrB gene" CDS complement(1898285..1898788) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /EC_number="1.10.2.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 24652282, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit)" /protein_id="NP_390137.1" /db_xref="EnsemblGenomes-Gn:BSU22560" /db_xref="EnsemblGenomes-Tr:CAB14172" /db_xref="GOA:P46911" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR014349" /db_xref="InterPro:IPR014909" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11325" /db_xref="UniProtKB/Swiss-Prot:P46911" /translation="MGGKHDISRRQFLNYTLTGVGGFMAASMLMPMVRFALDPVLKST GKQDMVQVVSVDELTKEPQRFDFKINQVDAWYESEESRSAWVFKNGDEIVALSPICKH LGCTVNWNSDPKNPNKFFCPCHYGLYEKDGTNVPGTPPLAPLDHYEQEVKDGFLYLGK AKPKGEG*" /label="qcrA CDS" gene complement(1898285..1898788) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /label="qcrA gene" downshifts 1898797 /Source="Nicolas_upshifts" /id="D1178" /incds=0 /nref=1 /ntot=80 /MaxReadThrough="1.24169" /MaxDrop="3.42621" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=3608 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1898852..1898871) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1898852) /Source="Nicolas_upshifts" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1898886..1898893) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1898931..1899377) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15743949" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390138.1" /db_xref="EnsemblGenomes-Gn:BSU22570" /db_xref="EnsemblGenomes-Tr:CAB14173" /db_xref="InterPro:IPR019615" /db_xref="SubtiList:BG11498" /db_xref="UniProtKB/Swiss-Prot:P54391" /translation="MRWRITDAKDYLQAKDYIDTAVIPLINIRVNNHFKMAAEKGEFT QLLSEELERQLKGRVYLLPPYTYVDRNEITVQGLKDLREELITEFPHVVLLTSDESWR AEDALGKMIVTSSVPLEHLNDSLKRKILDERTAEILNVLLQLWSTL*" /label="ypiF CDS" gene complement(1898931..1899377) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /label="ypiF gene" downshifts 1899380 /Source="Nicolas_upshifts" /id="D1179" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="0.94679" /MaxDrop="2.794" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=4191 /isTUend="FALSE" /label="downshifts" CDS complement(1899432..1899971) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16847875" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390139.1" /db_xref="EnsemblGenomes-Gn:BSU22580" /db_xref="EnsemblGenomes-Tr:CAB14174" /db_xref="InterPro:IPR011188" /db_xref="InterPro:IPR014957" /db_xref="InterPro:IPR014963" /db_xref="SubtiList:BG11497" /db_xref="UniProtKB/Swiss-Prot:P54390" /translation="MQTPVSVNEKKDFIRWFLNHYQLKRRECVWILNYLMSHDSLMEK VHFVEQAEFCPRGIIMSTHCVEEVPFRFYKENVMTTDAEKSFHDIRLNKQQDLFIQLN FRSAYSSPEYAAVLESNPHIPKNLFENKKDQGLAEQILEHAISTFQREKLLKDIDDAL DRHDKEAFEQLSRQLNQLT*" /label="ypiB CDS" gene complement(1899432..1899971) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /label="ypiB gene" downshifts complement(1899445) /Source="Nicolas_upshifts" /id="D1180" /incds=0 /nref=84 /ntot=250 /MaxReadThrough="5.68366" /MaxDrop="5.48142" /score="16.8021869" /energy="-11.2" /TU="U1766,U1767" /idTUdmin="U1768" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1900004..1900022) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1900015) /Source="Nicolas_upshifts" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="upshifts" promotor_-35 complement(1900034..1900042) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" CDS complement(1900043..1901314) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390140.1" /db_xref="EnsemblGenomes-Gn:BSU22590" /db_xref="EnsemblGenomes-Tr:CAB14175" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11496" /db_xref="UniProtKB/Swiss-Prot:P54389" /translation="MNTLIQEAIKLVEAGETEKGLNTLSKAEKQLHDEDKAIAAQLYY EWGDVEKAISLISDLHDLYPNETELTNFYAELLIDIDEEEKALAVLETIPETDPSYPE SLLLMADLYQMQGLFEVSEQKLFQAKSILDNEPVIDFALGELYFAQGAYAKAVQYFKT TAEEQSEIGGVNVHQRLAESLSASGEFEDAIPWYEKAVDENPDPNTIFGYGFTALQAG LVKTAIKQLSDLKELDPSYTSLYMPLSKSYEAEGMYEEALKTAKEGIRYDEYNKELFL YAAKMALKIGKSEEGKKLLQEALALDPGFVEALHTLLAVYHKEEDYDQIIDLIQEVRS YGEEDPKYNWYLASAYTELEQYEEAKQSFEAAYLHYREDRDFLYEYASFLLEEGLQKE ALPLLKKVLEMDGANEELEETILRIEDEFSR*" /label="ypiA CDS" gene complement(1900043..1901314) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /label="ypiA gene" S_feature complement(1901315..1901382) /Source="Nicolas_S_feature" /locus_tag="new_2367619_2367686_c" /HighExp="dia15, Diami, dia5, Etha, H2O2, T1.30H, LPhT, T0.30H, T3.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF, SigA" /TUshortPSig="0.999, 0.999, 0.999, 1" /TUlongSig="Sig-, Sig-, SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.047, 0.994, 0.999, 1, 0.999, 1, 0.998" /label="S855" promotor_-10 complement(1901379..1901398) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1901382) /Source="Nicolas_upshifts" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1901412..1901419) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1901449..1901468) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1901455) /Source="Nicolas_upshifts" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="upshifts" S_feature complement(1901457..1901601) /Source="Nicolas_S_feature" /locus_tag="new_2367761_2367905_c" /HighExp="S3, LoTm, M9-stat, S4, Etha, S5, T5.0H, BT, B36, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.047, 0.994" /TUlongSig="Sig-, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.999, 1, 0.999, 1, 0.998" /label="S856" promotor_-35 complement(1901479..1901486) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" promotor_-10 complement(1901583..1901601) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1901601) /Source="Nicolas_upshifts" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1901617..1901622) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1901650..1902936) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /EC_number="2.5.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3106153, 22938038, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvoylshikimate-3-phosphate synthase)" /protein_id="NP_390141.1" /db_xref="EnsemblGenomes-Gn:BSU22600" /db_xref="EnsemblGenomes-Tr:CAB14176" /db_xref="GOA:P20691" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR006264" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR023193" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10294" /db_xref="UniProtKB/Swiss-Prot:P20691" /translation="MKRDKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPG ADCLSTIDCFRKMGVHIEQSSSDVVIHGKGIDALKEPESLLDVGNSGTTIRLMLGILA GRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVS PVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLSAFGVKLSEDQTSVSIAGGQ KLTAADIFVPGDISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTGIIDVLQNMGAKLEI KPSADSGAEPYGDLIIETSSLKAVEIGGDIIPRLIDEIPIIALLATQAEGTTVIKDAA ELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLG IASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKKS*" /label="aroA CDS" gene complement(1901650..1902936) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /label="aroA gene" downshifts complement(1901673) /Source="Nicolas_upshifts" /id="D1181" /incds=0 /nref=68 /ntot=212 /MaxReadThrough="3.64462" /MaxDrop="4.25336" /score="16.8021869" /energy="-11.2" /TU="U1770,U1772,U1773" /idTUdmin="U1775" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1902947..1904062) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /EC_number="1.3.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106153, 3121591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106153, 3121591; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydrogenase" /protein_id="NP_390142.1" /db_xref="EnsemblGenomes-Gn:BSU22610" /db_xref="EnsemblGenomes-Tr:CAB14177" /db_xref="GOA:P20692" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003099" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10293" /db_xref="UniProtKB/Swiss-Prot:P20692" /translation="MNQMKDTILLAGLGLIGGSIALAIKKNHPGKRIIGIDISDEQAV AALKLGVIDDRADSFISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGST KQKVVDYADQVLPSRYQFVGGHPMAGSHKSGVAAAKEFLFENAFYILTPGQKTDKQAV EQLKNLLKGTNAHFVEMSPEEHDGVTSVISHFPHIVAASLVHQTHHSENLYPLVKRFA AGGFRDITRIASSSPAMWRDILLHNKDKILDRFDEWIREIDKIRTYVEQEDAENLFRY FKTAKDYRDGLPLRQKGAIPAFYDLYVDVPDHPGVISEITAILAAERISITNIRIIET REDINGILRISFQSDDDRKRAEQCIEARAEYETFYAD*" /label="tyrA CDS" gene complement(1902947..1904062) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /label="tyrA gene" CDS complement(1904111..1905193) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /EC_number="2.6.1.5" /EC_number="2.6.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4431, 418816, 824269, 11518529, 15102328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4431, 418816, 824269, 11518529, 15102328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous)" /protein_id="NP_390143.2" /db_xref="EnsemblGenomes-Gn:BSU22620" /db_xref="EnsemblGenomes-Tr:CAB14178" /db_xref="GOA:P17731" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR005861" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10292" /db_xref="UniProtKB/Swiss-Prot:P17731" /translation="MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCS EAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFL NDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICS PNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMIL RTFSKAYGLAALRVGYGIADENLIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCV EQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQALLEKGYIVRSGNALG FPTSLRITIGTKEQNEEILAILAEIL*" /label="hisC CDS" gene complement(1904111..1905193) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /label="hisC gene" CDS complement(1905204..1906007) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (alpha subunit)" /protein_id="NP_390144.1" /db_xref="EnsemblGenomes-Gn:BSU22630" /db_xref="EnsemblGenomes-Tr:CAB14179" /db_xref="GOA:P07601" /db_xref="InterPro:IPR002028" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018204" /db_xref="SubtiList:BG10291" /db_xref="UniProtKB/Swiss-Prot:P07601" /translation="MFKLDLQPSEKLFIPFITAGDPVPEVSIELAKSLQKAGATALEL GVAYSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGVNIPIILFTYYNPVLQ LNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISLVAPTSESRLKTII EQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNLSTVPVAVGFGISNREQVIKMNE ISDGVVVGSALVRKIEELKDRLISAETRNQALQEFEDYAMAFSGLYSLK*" /label="trpA CDS" gene complement(1905204..1906007) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /label="trpA gene" promotor_-10 complement(1905692..1905711) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1905709) /Source="Nicolas_upshifts" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1905723..1905730) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1906000..1907202) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (beta subunit)" /protein_id="NP_390145.2" /db_xref="EnsemblGenomes-Gn:BSU22640" /db_xref="EnsemblGenomes-Tr:CAB14180" /db_xref="GOA:P07600" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR006653" /db_xref="InterPro:IPR006654" /db_xref="InterPro:IPR023026" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10290" /db_xref="UniProtKB/Swiss-Prot:P07600" /translation="MYPYPNEIGRYGDFGGKFVPETLMQPLDEIQTAFKQIKDDPAFR EEYYKLLKDYSGRPTALTYADRVTEYLGGAKIYLKREDLNHTGSHKINNALGQALLAK KMGKTKIIAETGAGQHGVAAATVAAKFGFSCTVFMGEEDVARQSLNVFRMKLLGAEVV PVTSGNGTLKDATNEAIRYWVQHCEDHFYMIGSVVGPHPYPQVVREFQKMIGEEAKDQ LKRIEGTMPDKVVACVGGGSNAMGMFQAFLNEDVELIGAEAAGKGIDTPLHAATISKG TVGVIHGSLTYLIQDEFGQIIEPYSISAGLDYPGIGPEHAYLHKSGRVTYDSITDEEA VDALKLLSEKEGILPAIESAHALAKAFKLAKGMDRGQLILVCLSGRGDKDVNTLMNVL EEEVKAHV*" /label="trpB CDS" gene complement(1906000..1907202) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /label="trpB gene" CDS complement(1907183..1907830) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /EC_number="5.3.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylanthranilate isomerase" /protein_id="NP_390146.3" /db_xref="EnsemblGenomes-Gn:BSU22650" /db_xref="EnsemblGenomes-Tr:CAB14181" /db_xref="GOA:P20167" /db_xref="InterPro:IPR001240" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10289" /db_xref="UniProtKB/Swiss-Prot:P20167" /translation="MKKPALKYCGIRSLKDLQLAAESQADYLGFIFAESKRKVSPEDV KKWLNQVRVEKQVAGVFVNESIETMSRIAKSLKLDVIQLHGDEKPADAAALRKLTGCE IWKALHHQDNTTQEIARFKDNVDGFVIDSSVKGSRGGTGVAFSWECVPEYQQAAIGKR CFIAGGVNPDSITRLLKWQPEGIDLASGIEKNGQKDQNLMRLLEERMNRYVSISE*" /label="trpF CDS" gene complement(1907183..1907830) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /label="trpF gene" downshifts complement(1907277) /Source="Nicolas_upshifts" /id="D1182" /incds=1 /nref=30 /ntot=83 /MaxReadThrough="8.17917" /MaxDrop="5.75867" /score="2.96963632" /energy="-11.9" /TU="U1771,U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=616 /isTUend="FALSE" /label="downshifts" misc_feature complement(1907453..1907456) /Source="Nicolas_upshift_promotors" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1907453) /Source="Nicolas_upshifts" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" downshifts complement(1907673) /Source="Nicolas_upshifts" /id="D1183" /incds=1 /nref=1 /ntot=84 /MaxReadThrough="8.55417" /MaxDrop="3.4408" /score="2.96963632" /energy="-11.9" /TU="U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=220 /isTUend="FALSE" /label="downshifts" misc_feature 1907835..1908587 /created_by="AR/SM" /id="IIG_Bs01" /note="due to the curing of the trpC2 locus (auxotrophy) of the Delta6 strain by transformation with chromosomal DNA from donor Bsu 3NA multiple snp`s were transferred to the oroginal trpC locus" /modified_by="User" /label="IIG_Bs01" /note="Geneious type: MiniBacillus__exchange" CDS complement(1907835..1908587) /locus_tag="PG10_trpC_var_BEP06_07765" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_007409461.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="indole-3-glycerol phosphate synthase" /protein_id="ANY35339.1" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /translation="MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASLNRFIGLIA EVKKASPSKGLIKENFVPVRIAKDYETAKADALSVLTDTPFFQGENSYLSDVKRAVSI PVLRKDFIIDSLQVEESRRIGADAILLIGEVLDPLHLHELYLEAGEKEMDVLVEVHDA TTLEQILKVFTPDILGINNRNLKTFETSIMQTEQIASLAPKESLLVSESGIGSLEHLT FVKEHGARAVLIGESLMRQTSQRKAIHALFRE*" /label="PG10_trpC_var_BEP06_07765" gene complement(1907835..1908587) /locus_tag="PG10_trpC_var_BEP06_07765" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /label="PG10_trpC_var_BEP06_07765" misc_feature complement(1907868..1907870) /Source="Nicolas_upshift_promotors" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1907871 /Source="Nicolas_upshifts" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" Polymorphism join(1907977,1907980) /Source="geneious" /ID="SNP_BsPG10_2374282_2374283" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change /CDS_Position=606 /Change="AG -> GT" /Codon_Change="TCC,TTG -> TCA,CTG" /Coverage="129 -> 130" /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="AG" /Variant_Nucleotides="GT" /Variant_P_Value="2e-203" /Variant_Raw_Frequency="128 -> 129" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1907991,1907993) /Source="geneious" /ID="SNP_BsPG10_2374296_2374296" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> A" /CDS_Position=593 /Change="A -> G" /Codon_Change="GTT -> GCT" /Coverage=119 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.2e-179" /Variant_Raw_Frequency=119 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1907993,1907995) /Source="geneious" /ID="SNP_BsPG10_2374298_2374298" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=591 /Change="G -> A" /Codon_Change="CTC -> CTT" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="9.9e-148" /Variant_Raw_Frequency=116 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908018,1908020) /Source="geneious" /ID="SNP_BsPG10_2374323_2374323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="K -> M" /CDS_Position=566 /Change="T -> A" /Codon_Change="AAG -> ATG" /Coverage=81 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="A" /Variant_P_Value="6.3e-98" /Variant_Raw_Frequency=81 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908020,1908024) /Source="geneious" /ID="SNP_BsPG10_2374325_2374327" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="V -> I" /CDS_Position=562 /Change="TAC -> GAT" /Codon_Change="GTA -> ATC" /Coverage="79 -> 84" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="TAC" /Variant_Nucleotides="GAT" /Variant_P_Value="2.3e-77" /Variant_Raw_Frequency="74 -> 78" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908026,1908028) /Source="geneious" /ID="SNP_BsPG10_2374331_2374331" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=558 /Change="T -> G" /Codon_Change="ACA -> ACC" /Coverage=70 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="1e-63" /Variant_Raw_Frequency=70 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908035,1908037) /Source="geneious" /ID="SNP_BsPG10_2374340_2374340" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=549 /Change="C -> A" /Codon_Change="ACG -> ACT" /Coverage=59 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="A" /Variant_P_Value="1e-59" /Variant_Raw_Frequency=59 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908050,1908052) /Source="geneious" /ID="SNP_BsPG10_2374355_2374355" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=534 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=66 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="6e-64" /Variant_Raw_Frequency=65 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908053,1908055) /Source="geneious" /ID="SNP_BsPG10_2374358_2374358" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=531 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=63 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.3e-68" /Variant_Raw_Frequency=60 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908058,1908060) /Source="geneious" /ID="SNP_BsPG10_2374363_2374363" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> I" /CDS_Position=526 /Change="C -> T" /Codon_Change="GTA -> ATA" /Coverage=65 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="3.9e-82" /Variant_Raw_Frequency=64 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908068,1908070) /Source="geneious" /ID="SNP_BsPG10_2374373_2374373" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=516 /Change="G -> A" /Codon_Change="GAC -> GAT" /Coverage=79 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="7.7e-116" /Variant_Raw_Frequency=78 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908071,1908073) /Source="geneious" /ID="SNP_BsPG10_2374376_2374376" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=513 /Change="G -> A" /Codon_Change="CCC -> CCT" /Coverage=92 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="4e-141" /Variant_Raw_Frequency=90 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908074,1908076) /Source="geneious" /ID="SNP_BsPG10_2374379_2374379" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=510 /Change="T -> C" /Codon_Change="ACA -> ACG" /Coverage=97 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.3e-165" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908080,1908082) /Source="geneious" /ID="SNP_BsPG10_2374385_2374385" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=504 /Change="C -> T" /Codon_Change="GTG -> GTA" /Coverage=109 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="4.3e-193" /Variant_Raw_Frequency=108 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908106,1908108) /Source="geneious" /ID="SNP_BsPG10_2374411_2374411" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="S -> T" /CDS_Position=478 /Change="A -> T" /Codon_Change="TCA -> ACA" /Coverage=148 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value="2.9e-307" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908138,1908140) /Source="geneious" /ID="SNP_BsPG10_2374443_2374443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="G -> E" /CDS_Position=446 /Change="C -> T" /Codon_Change="GGG -> GAG" /Coverage=161 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=161 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908191,1908193) /Source="geneious" /ID="SNP_BsPG10_2374496_2374496" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=393 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=174 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908239,1908241) /Source="geneious" /ID="SNP_BsPG10_2374544_2374544" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=345 /Change="T -> C" /Codon_Change="GTA -> GTG" /Coverage=168 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=167 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908254,1908258) /Source="geneious" /ID="SNP_BsPG10_2374559_2374558" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=0 /Amino_Acid_Change="-> I" /CDS_Position=331 /Change="AAT" /Codon_Change="-> ATT" /Coverage=164 /locus_tag="BSU_22660" /Protein_Effect="Insertion" /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="AAT" /Variant_P_Value="3.90000001038273e-316" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908272,1908274) /Source="geneious" /ID="SNP_BsPG10_2374574_2374574" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=315 /Change="A -> G" /Codon_Change="CTT -> CTC" /Coverage=155 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908281,1908283) /Source="geneious" /ID="SNP_BsPG10_2374583_2374583" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=306 /Change="A -> T" /Codon_Change="ATT -> ATA" /Coverage=153 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=152 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908293,1908295) /Source="geneious" /ID="SNP_BsPG10_2374595_2374595" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=294 /Change="A -> G" /Codon_Change="CGT -> CGC" /Coverage=128 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="4e-295" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908358,1908360) /Source="geneious" /ID="SNP_BsPG10_2374660_2374660" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="I -> L" /CDS_Position=229 /Change="T -> G" /Codon_Change="ATT -> CTT" /Coverage=131 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="2.3e-302" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908368,1908370) /Source="geneious" /ID="SNP_BsPG10_2374670_2374670" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=219 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=126 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="1.6e-290" /Variant_Raw_Frequency=126 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908376,1908379) /Source="geneious" /ID="SNP_BsPG10_2374678_2374679" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="EA -> ET" /CDS_Position=210 /Change="CC -> TT" /Codon_Change="GAG,GCT -> GAA,ACT" /Coverage="124 -> 130" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="CC" /Variant_Nucleotides="TT" /Variant_P_Value="4.7e-253" /Variant_Raw_Frequency="119 -> 125" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908396,1908398) /Source="geneious" /ID="SNP_BsPG10_2374698_2374698" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="Q -> R" /CDS_Position=191 /Change="T -> C" /Codon_Change="CAG -> CGG" /Coverage=104 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="9e-228" /Variant_Raw_Frequency=101 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908412,1908414) /Source="geneious" /ID="SNP_BsPG10_2374714_2374714" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="D -> N" /CDS_Position=175 /Change="C -> T" /Codon_Change="GAT -> AAT" /Coverage=95 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency="1.1%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="2.8e-220" /Variant_Raw_Frequency=93 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908440,1908442) /Source="geneious" /ID="SNP_BsPG10_2374742_2374742" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=147 /Change="T -> C" /Codon_Change="GCA -> GCG" /Coverage=98 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.2e-260" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908455,1908457) /Source="geneious" /ID="SNP_BsPG10_2374757_2374757" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=132 /Change="G -> A" /Codon_Change="GCC -> GCT" /Coverage=197 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value /Variant_Raw_Frequency /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908480,1908482) /Source="geneious" /ID="SNP_BsPG10_2374782_2374782" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="P -> L" /CDS_Position=107 /Change="G -> A" /Codon_Change="CCG -> CTG" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value=0 /Variant_Raw_Frequency=118 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908497,1908499) /Source="geneious" /ID="SNP_BsPG10_2374799_2374799" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=90 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=133 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=131 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1908512,1908514) /Source="geneious" /ID="SNP_BsPG10_2374814_2374814" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=75 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=130 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=130 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" CDS complement(1908580..1909596) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /EC_number="2.4.2.18" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 17114058; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="anthranilate phosphoribosyltransferase" /protein_id="NP_390148.2" /db_xref="EnsemblGenomes-Gn:BSU22670" /db_xref="EnsemblGenomes-Tr:CAB14183" /db_xref="GOA:P03947" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR005940" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="SubtiList:BG10288" /db_xref="UniProtKB/Swiss-Prot:P03947" /modified_by="User" /translation="MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILA HRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGA KIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHV AGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSS RDGLDELSITAPTDVIELKDGERREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNI FENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSGGAAAQLERLKQKEE EIYA*" /label="trpD CDS" gene complement(1908580..1909596) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /modified_by="User" /label="trpD gene" CDS complement(1909568..1911115) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anthranilate synthase" /protein_id="NP_390149.1" /db_xref="EnsemblGenomes-Gn:BSU22680" /db_xref="EnsemblGenomes-Tr:CAB14184" /db_xref="GOA:P03963" /db_xref="InterPro:IPR005256" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10287" /db_xref="UniProtKB/Swiss-Prot:P03963" /translation="MNFQSNISAFLEDSLSHHTIPIVETFTVDTLTPIQMIEKLDREI TYLLESKDDTSTWSRYSFIGLNPFLTIKEEQGRFSAADQDSKSLYTGNELKEVLNWMN TTYKIKTPELGIPFVGGAVGYLSYDMIPLIEPSVPSHTKETDMEKCMLFVCRTLIAYD HETKNVHFIQYARLTGEETKNEKMDVFHQNHLELQNLIEKMMDQKNIKELFLSADSYK TPSFETVSSNYEKSAFMADVEKIKSYIKAGDIFQGVLSQKFEVPIKADAFELYRVLRI VNPSPYMYYMKLLDREIVGSSPERLIHVQDGHLEIHPIAGTRKRGADKAEDERLKVEL MKDEKEKAEHYMLVDLARNDIGRVAEYGSVSVPEFTKIVSFSHVMHIISVVTGRLKKG VHPVDALMSAFPAGTLTGAPKIRAMQLLQELEPTPRETYGGCIAYIGFDGNIDSCITI RTMSVKNGVASIQAGAGIVADSVPEAEYEESCNKAGALLKTIHIAEDMFHSKEDKADE QISTIVR*" /label="trpE CDS" gene complement(1909568..1911115) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /label="trpE gene" S_feature complement(1911194..1911325) /Source="Nicolas_S_feature" /locus_tag="new_2377495_2377626_c" /HighExp="Etha, S1, GM 25, GM 15, HiTm, Glu, MG-0.1, GM 60, M9-exp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.994, 0.647, 0.999, 1, 0.996" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.998" /label="S857" downshifts complement(1911237) /Source="Nicolas_upshifts" /id="D1184" /incds=0 /nref=61 /ntot=157 /MaxReadThrough="7.41666" /MaxDrop="5.25158" /score="2.96963632" /energy="-11.9" /TU="U1773,U1774,U1775,U1776" /idTUdmin="U1777" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1911316..1911335) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-10" upshifts complement(1911325) /Source="Nicolas_upshifts" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" CDS complement(1911331..1911714) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate mutase" /protein_id="NP_390150.1" /db_xref="EnsemblGenomes-Gn:BSU22690" /db_xref="EnsemblGenomes-Tr:CAB14185" /db_xref="GOA:P19080" /db_xref="InterPro:IPR008243" /db_xref="InterPro:IPR035959" /db_xref="PDB:1COM" /db_xref="PDB:1DBF" /db_xref="PDB:1FNJ" /db_xref="PDB:1FNK" /db_xref="PDB:2CHS" /db_xref="PDB:2CHT" /db_xref="PDB:3ZO8" /db_xref="PDB:3ZOP" /db_xref="PDB:3ZP4" /db_xref="PDB:3ZP7" /db_xref="SubtiList:BG10286" /db_xref="UniProtKB/Swiss-Prot:P19080" /translation="MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQ MLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQD QIRHVYLEKVVVLRPDLSLTKNTEL*" /label="aroH CDS" gene complement(1911331..1911714) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /label="aroH gene" promotor_-35 complement(1911350..1911357) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-35" CDS complement(1911711..1912799) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /EC_number="4.2.3.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate synthase" /protein_id="NP_390151.1" /db_xref="EnsemblGenomes-Gn:BSU22700" /db_xref="EnsemblGenomes-Tr:CAB14186" /db_xref="GOA:P31102" /db_xref="InterPro:IPR016037" /db_xref="InterPro:IPR030960" /db_xref="InterPro:IPR030963" /db_xref="SubtiList:BG10285" /db_xref="UniProtKB/Swiss-Prot:P31102" /translation="MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTD EEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRSSCIIA FGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQP KAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMI FKGISIKASVVQQDEKEEGIRAYLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALY ISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLN ELGKVADHTFSRNELESWLNKWRLEETS*" /label="aroB CDS" gene complement(1911711..1912799) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /label="aroB gene" promotor_-10 complement(1911840..1911855) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(1911853) /Source="Nicolas_upshifts" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(1911868..1911876) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(1912799..1913971) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /EC_number="4.2.3.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 10518299, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 10518299, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate synthase" /protein_id="NP_390152.3" /db_xref="EnsemblGenomes-Gn:BSU22710" /db_xref="EnsemblGenomes-Tr:CAB14187" /db_xref="GOA:P31104" /db_xref="InterPro:IPR000453" /db_xref="InterPro:IPR020541" /db_xref="InterPro:IPR035904" /db_xref="SubtiList:BG10284" /db_xref="UniProtKB/Swiss-Prot:P31104" /translation="MRYLTAGESHGPQLTTIIEGVPAGLYITEEDINFELARRQKGHG RGRRMQIEKDQAKIMSGVRHARTLGSPIALVVENNDWKHWTKIMGAAPITEDEEKEMK RQISRPRPGHADLNGAIKYNHRDMRNVLERSSARETTVRVAAGAVAKKILSELGIKVA GHVLQIGAVKAEKTEYTSIEDLQRVTEESPVRCYDEEAGKKMMAAIDEAKANGDSIGG IVEVIVEGMPVGVGSYVHYDRKLDSKLAAAVLSINAFKGVEFGIGFEAAGRNGSEVHD EIIWDEEKGYTRATNRLGGLEGGMTTGMPIVVRGVMKPIPTLYKPLKSVDIETKEPFS ASIERSDSCAVPAASVVAEAAVAWEIANAVVEQFGLDQIDRIRENVENMRKLSREF*" /label="aroF CDS" gene complement(1912799..1913971) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /label="aroF gene" promotor_-10 complement(1914006..1914025) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1914023) /Source="Nicolas_upshifts" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1914038..1914045) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1914046..1914816) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /EC_number="2.1.1.80" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCPs) methyltransferase" /protein_id="NP_390153.2" /db_xref="EnsemblGenomes-Gn:BSU22720" /db_xref="EnsemblGenomes-Tr:CAB14188" /db_xref="GOA:P31105" /db_xref="InterPro:IPR000780" /db_xref="InterPro:IPR022641" /db_xref="InterPro:IPR022642" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036804" /db_xref="PDB:5FTW" /db_xref="SubtiList:BG10283" /db_xref="UniProtKB/Swiss-Prot:P31105" /translation="MDTYSVFTTKWKQLTGVDLTLYKEAQMKRRLTSLYEKKGFQSFK DFAAALEKDQALLNETLDRMTINVSEFYRNYKRWEVLETAILPLIKTSRPLKIWSAAC STGEEPYTLAMLLDQQKGLPGYQILATDIDEKALEKAKKGVYQERSLQEVPLSVKDRY FTQNANRSYEVKTEIKKNITFKKHNLLADRYEQDFDLIVCRNVFIYFTESAKEELYLK MAHSLKKNGVLFVGSTEQIFNPEKFGLVPADTFFYQKR*" /label="cheR CDS" gene complement(1914046..1914816) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /label="cheR gene" promotor_-10 complement(1914842..1914861) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1914859) /Source="Nicolas_upshifts" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1914873..1914879) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" S_feature complement(1914891..1915052) /Source="Nicolas_S_feature" /locus_tag="new_2381192_2381353_c" /HighExp="M0t90, Lbstat, S0, Mt0, M0t45, M40t90, Lbtran, Mal, G/S, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.996, 0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S858" downshifts complement(1914934) /Source="Nicolas_upshifts" /id="D1185" /incds=0 /nref=26 /ntot=128 /MaxReadThrough="4.04342" /MaxDrop="4.7493" /score="29.2259705" /energy="-8.6" /TU="U1777,U1778,U1779,U1780" /idTUdmin="U1778" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" CDS complement(1915053..1915502) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /EC_number="2.7.4.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 11734624, 22720735, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside diphosphate kinase" /protein_id="NP_390154.1" /db_xref="EnsemblGenomes-Gn:BSU22730" /db_xref="EnsemblGenomes-Tr:CAB14189" /db_xref="GOA:P31103" /db_xref="InterPro:IPR001564" /db_xref="InterPro:IPR023005" /db_xref="InterPro:IPR034907" /db_xref="InterPro:IPR036850" /db_xref="SubtiList:BG10282" /db_xref="UniProtKB/Swiss-Prot:P31103" /translation="MMEKTFIMVKPDGVQRQLIGDILSRFERKGLQLAGAKLMRVTEQ MAEKHYAEHQGKPFFGELVEFITSGPVFAMVWEGENVIEVTRQLIGKTNPKEALPGTI RGDYGMFVGKNIIHGSDSLESAEREINIFFKNEELVSYQQLMAGWIY*" /label="ndk CDS" gene complement(1915053..1915502) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /label="ndk gene" promotor_-10 complement(1915545..1915564) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(1915552) /Source="Nicolas_upshifts" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(1915577..1915584) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(1915618..1916664) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /EC_number="2.5.1.30" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component II" /protein_id="NP_390155.1" /db_xref="EnsemblGenomes-Gn:BSU22740" /db_xref="EnsemblGenomes-Tr:CAB14190" /db_xref="GOA:P31114" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR014119" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG10281" /db_xref="UniProtKB/Swiss-Prot:P31114" /translation="MLNIIRLLAESLPRISDGNENTDVWVNDMKFKMAYSFLNDDIDV IERELEQTVRSDYPLLSEAGLHLLQAGGKRIRPVFVLLSGMFGDYDINKIKYVAVTLE MIHMASLVHDDVIDDAELRRGKPTIKAKWDNRIAMYTGDYMLAGSLEMMTRINEPKAH RILSQTIVEVCLGEIEQIKDKYNMEQNLRTYLRRIKRKTALLIAVSCQLGAIASGADE KIHKALYWFGYYVGMSYQIIDDILDFTSTEEELGKPVGGDLLQGNVTLPVLYALKNPA LKNQLKLINSETTQEQLEPIIEEIKKTDAIEASMAVSEMYLQKAFQKLNTLPRGRARS SLAAIAKYIGKRKF*" /label="hepT CDS" gene complement(1915618..1916664) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /label="hepT gene" CDS complement(1916606..1917307) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /EC_number="2.1.1.163" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16279806, 9045837, 9139683, 21513522, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16279806, 9045837, 9139683, 21513522, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="demethylmenaquinone methyltransferase" /protein_id="NP_390156.1" /db_xref="EnsemblGenomes-Gn:BSU22750" /db_xref="EnsemblGenomes-Tr:CAB14191" /db_xref="GOA:P31113" /db_xref="InterPro:IPR004033" /db_xref="InterPro:IPR014122" /db_xref="InterPro:IPR023576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10280" /db_xref="UniProtKB/Swiss-Prot:P31113" /translation="MQDSKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMRIMN VKEGAKALDVCCGTADWTIALAKAAGKSGEIKGLDFSENMLSVGEQKVKDGGFSQIEL LHGNAMELPFDDDTFDYVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMF GFRQAYFMYFKYIMPFFGKLFAKSYKEYSWLQESARDFPGMKELAGLFEEAGLKNVKY HSFTGGVAATHIGWK*" /label="menG CDS" gene complement(1916606..1917307) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /label="menG gene" CDS complement(1917314..1918069) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /EC_number="2.5.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component I" /protein_id="NP_390157.1" /db_xref="EnsemblGenomes-Gn:BSU22760" /db_xref="EnsemblGenomes-Tr:CAB14192" /db_xref="GOA:P31112" /db_xref="InterPro:IPR009920" /db_xref="SubtiList:BG10279" /db_xref="UniProtKB/Swiss-Prot:P31112" /translation="MQDIYGTLANLNTKLKQKLSHPYLAKHISAPKIDEDKLLLFHAL FEEADIKNNDRENYIVTAMLVQSALDTHDEVTTARVIKRDENKNRQLTVLAGDYFSGL YYSLLSEMKDIYMIRTLATAIKEINEHKIRLYDRSFKDENDFFESVGIVESALFHRVA EHFNLPRWKKLSSDFFVFKRLMNGNDAFLDVIGSFIQLGKTKEEILEDCFKKAKNSIE SLLPLNSPIQNILINRLKTISQDQTYHQKVEEG*" /label="hepS CDS" gene complement(1917314..1918069) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /label="hepS gene" S_feature complement(1918070..1918155) /Source="Nicolas_S_feature" /locus_tag="new_2384371_2384456_c" /HighExp="H2O2, G150, G180, Paraq, Oxctl, G135, T-4.40H, Lbexp, T-3.40H, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S859" promotor_-10 complement(1918144..1918163) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1918155) /Source="Nicolas_upshifts" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1918174..1918181) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1918233..1918460) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15099736, 15588817, 16285852, 16306262, 17114058, 28069823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15099736, 15588817, 16285852, 16306262, 17114058, 28069823; Product type r : regulator" /codon_start=1 /transl_table=11 /product="tryptophan operon RNA-binding attenuation protein (TRAP)" /protein_id="NP_390158.1" /db_xref="EnsemblGenomes-Gn:BSU22770" /db_xref="EnsemblGenomes-Tr:CAB14193" /db_xref="GOA:P19466" /db_xref="InterPro:IPR000824" /db_xref="InterPro:IPR016031" /db_xref="InterPro:IPR023558" /db_xref="PDB:1WAP" /db_xref="PDB:3ZZQ" /db_xref="PDB:4B27" /db_xref="SubtiList:BG10278" /db_xref="UniProtKB/Swiss-Prot:P19466" /translation="MNQKHSSDFVVIKAVEDGVNVIGLTRGTDTKFHHSEKLDKGEVI IAQFTEHTSAIKVRGEALIQTAYGEMKSEKK*" /label="mtrB CDS" gene complement(1918233..1918460) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /label="mtrB gene" downshifts complement(1918254) /Source="Nicolas_upshifts" /id="D1186" /incds=0 /nref=22 /ntot=162 /MaxReadThrough="6.02348" /MaxDrop="4.385" /score="8.50521108" /energy="-10.5" /TU="U1779,U1780" /idTUdmin="U1781" /TUdmin=1499 /isTUend="FALSE" /label="downshifts" CDS complement(1918482..1919054) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1551827, 12559918, 14717702, 17032654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1551827, 12559918, 14717702, 17032654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_390159.1" /db_xref="EnsemblGenomes-Gn:BSU22780" /db_xref="EnsemblGenomes-Tr:CAB14194" /db_xref="GOA:P19465" /db_xref="InterPro:IPR001474" /db_xref="InterPro:IPR018234" /db_xref="InterPro:IPR020602" /db_xref="SubtiList:BG10277" /db_xref="UniProtKB/Swiss-Prot:P19465" /translation="MKEVNKEQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVF SGLNEDPKEHFQTIFGENHEELVLVKDIAFHSMCEHHLVPFYGKAHVAYIPRGGKVTG LSKLARAVEAVAKRPQLQERITSTIAESIVETLDPHGVMVVVEAEHMCMTMRGVRKPG AKTVTSAVRGVFKDDAAARAEVLEHIKRQD*" /label="folEA CDS" gene complement(1918482..1919054) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /label="folEA gene" promotor_-10 complement(1919083..1919102) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1919093) /Source="Nicolas_upshifts" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" S_feature complement(1919095..1919178) /Source="Nicolas_S_feature" /locus_tag="new_2385396_2385479_c" /HighExp="Oxctl, G150, G180, G135, LBGexp, Paraq, LPh, H2O2, aero, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S860" promotor_-35 complement(1919115..1919121) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" downshifts complement(1919223) /Source="Nicolas_upshifts" /id="D1187" /incds=0 /nref=33 /ntot=254 /MaxReadThrough="6.68474" /MaxDrop="5.1938" /score="8.50521108" /energy="-10.5" /TU="U1780" /idTUdmin="U1781" /TUdmin=530 /isTUend="FALSE" /label="downshifts" CDS complement(1919242..1919520) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /function="16.1: Circulate" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617; Product type f: factor" /codon_start=1 /transl_table=11 /product="non-specific DNA-binding protein HBsu" /protein_id="NP_390160.1" /db_xref="EnsemblGenomes-Gn:BSU22790" /db_xref="EnsemblGenomes-Tr:CAB14195" /db_xref="GOA:P08821" /db_xref="InterPro:IPR000119" /db_xref="InterPro:IPR010992" /db_xref="InterPro:IPR020816" /db_xref="SubtiList:BG10276" /db_xref="UniProtKB/Swiss-Prot:P08821" /translation="MNKTELINAVAEASELSKKDATKAVDSVFDTILDALKNGDKIQL IGFGNFEVRERSARKGRNPQTGEEIEIPASKVPAFKPGKALKDAVAGK*" /label="hbs CDS" gene complement(1919242..1919520) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /label="hbs gene" S_feature complement(1919521..1919746) /Source="Nicolas_S_feature" /locus_tag="new_2385822_2386047_c" /HighExp="dia5, C90, T-0.40H, G/S, S1, Salt, Lbexp, dia15, T-1.40H, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S861" promotor_-10 complement(1919728..1919747) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1919746) /Source="Nicolas_upshifts" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1919764..1919769) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1919894..1921372) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11160095, 17114257, 17427285, 24810258, 26387458, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160095, 17114257, 17427285, 24810258, 26387458, 28408070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="morphogenetic stage IV sporulation protein" /protein_id="NP_390161.1" /db_xref="EnsemblGenomes-Gn:BSU22800" /db_xref="EnsemblGenomes-Tr:CAB14196" /db_xref="GOA:P35149" /db_xref="InterPro:IPR014201" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10275" /db_xref="UniProtKB/Swiss-Prot:P35149" /translation="MEKVDIFKDIAERTGGDIYLGVVGAVRTGKSTFIKKFMELVVLP NISNEADRARAQDELPQSAAGKTIMTTEPKFVPNQAMSVHVSDGLDVNIRLVDCVGYT VPGAKGYEDENGPRMINTPWYEEPIPFHEAAEIGTRKVIQEHSTIGVVITTDGTIGDI ARSDYIEAEERVIEELKEVGKPFIMVINSVRPYHPETEAMRQDLSEKYDIPVLAMSVE SMRESDVLSVLREALYEFPVLEVNVNLPSWVMVLKENHWLRESYQESVKETVKDIKRL RDVDRVVGQFSEFEFIESAGLAGIELGQGVAEIDLYAPDHLYDQILKEVVGVEIRGRD HLLELMQDFAHAKTEYDQVSDALKMVKQTGYGIAAPALADMSLDEPEIIRQGSRFGVR LKAVAPSIHMIKVDVESEFAPIIGTEKQSEELVRYLMQDFEDDPLSIWNSDIFGRSLS SIVREGIQAKLSLMPENARYKLKETLERIINEGSGGLIAIIL*" /label="spoIVA CDS" gene complement(1919894..1921372) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /label="spoIVA gene" downshifts complement(1919907) /Source="Nicolas_upshifts" /id="D1188" /incds=0 /nref=59 /ntot=76 /MaxReadThrough="3.43222" /MaxDrop="7.13908" /score="13.6316529" /energy="-9.2" /TU="U1781" /idTUdmin="U1782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1921373..1921534) /Source="Nicolas_S_feature" /locus_tag="new_2387674_2387835_c" /HighExp="S3, S4, S5, S6, LoTm, S7, B36, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S862" promotor_-10 complement(1921521..1921539) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-10" upshifts complement(1921546) /Source="Nicolas_upshifts" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="upshifts" CDS complement(1921553..1922287) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein of unknown function" /protein_id="NP_390162.1" /db_xref="EnsemblGenomes-Gn:BSU22810" /db_xref="EnsemblGenomes-Tr:CAB14197" /db_xref="SubtiList:BG10274" /db_xref="UniProtKB/Swiss-Prot:P39911" /translation="MGKLKCAIIFAAVVFLSGCLYPNERKSSVHAIPYQDQLKQVQSA VDEFQKANGGLLPIQTKDMSTPLYQKYPIDFNRLAPRYIAEPPSTAFESGGDYQYVLV DVENDPTVKLIDLKMAEKIRDVKLRIQMYRQEHQYPPYKDVLSRDLFTLDEKKLGDGS SLTVTSPISGNSLPLMIDGDGEIYADYRTELASCLKKSKKTFKPGTEIQDMIWHETPF VPAFSVKYTVNDKQEPVFLENDMKKE*" /label="yphF CDS" gene complement(1921553..1922287) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /label="yphF gene" promotor_-35 complement(1921554..1921559) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-35" downshifts complement(1921579) /Source="Nicolas_upshifts" /id="D1189" /incds=0 /nref=6 /ntot=78 /MaxReadThrough="6.50932" /MaxDrop="4.759" /score="15.8109079" /energy="-12.7" /TU="U1782" /idTUdmin="U1783" /TUdmin=1100 /isTUend="FALSE" /label="downshifts" CDS complement(1922309..1922512) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390163.1" /db_xref="EnsemblGenomes-Gn:BSU22820" /db_xref="EnsemblGenomes-Tr:CAB14198" /db_xref="GOA:P50744" /db_xref="InterPro:IPR020076" /db_xref="SubtiList:BG11444" /db_xref="UniProtKB/Swiss-Prot:P50744" /translation="MNLALMKMWFALGSMGLMFLAVASIYLSRFKCQNRFLKIAISSF AYMCMLISGIIVFVVVFSGPVNE*" /label="yphE CDS" gene complement(1922309..1922512) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /label="yphE gene" promotor_-10 complement(1922548..1922567) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1922569) /Source="Nicolas_upshifts" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1922581..1922588) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1922634..1922833) /Source="Nicolas_S_feature" /locus_tag="new_2388935_2389134_c" /HighExp="S7, S8, S6, C30, BT, G135, G180, Oxctl, Cold, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, Sig-" /TUshortPSig="1, 1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S863" downshifts complement(1922677) /Source="Nicolas_upshifts" /id="D1190" /incds=0 /nref=264 /ntot=295 /MaxReadThrough="2.22999" /MaxDrop="8.05743" /score="26.216597" /energy="-14.1" /TU="NA" /idTUdmin="U1783" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1922808..1922827) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1922833) /Source="Nicolas_upshifts" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1922841..1922850) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1922850..1923887) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /EC_number="1.1.1.94" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592341, 12682299, 15557260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592341, 12682299, 15557260; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent glycerol-3-phosphate dehydrogenase" /protein_id="NP_390164.1" /db_xref="EnsemblGenomes-Gn:BSU22830" /db_xref="EnsemblGenomes-Tr:CAB14199" /db_xref="GOA:P46919" /db_xref="InterPro:IPR006109" /db_xref="InterPro:IPR006168" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR011128" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11366" /db_xref="UniProtKB/Swiss-Prot:P46919" /translation="MKKVTMLGAGSWGTALALVLTDNGNEVCVWAHRADLIHQINELH ENKDYLPNVKLSTSIKGTTDMKEAVSDADVIIVAVPTKAIREVLRQAVPFITKKAVFV HVSKGIEPDSLLRISEIMEIELPSDVRKDIVVLSGPSHAEEVGLRHPTTVTASSKSMR AAEEVQDLFINHNFRVYTNPDIIGVEIGGALKNIIALAAGITDGLGYGDNAKAALITR GLAEIARLGTKMGGNPLTFSGLTGVGDLIVTCTSVHSRNWRAGNLLGKGYKLEDVLEE MGMVVEGVRTTKAAYQLSKKYDVKMPITEALHQVLFNGQKVETAVESLMARGKTHEME DLVNTFENQVK*" /label="gpsA CDS" gene complement(1922850..1923887) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /label="gpsA gene" CDS complement(1923905..1925215) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /EC_number="3.6.5.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase essential for ribosome 50S subunit assembly (maturation of the 50S subunit central protoberance)" /protein_id="NP_390165.1" /db_xref="EnsemblGenomes-Gn:BSU22840" /db_xref="EnsemblGenomes-Tr:CAB14200" /db_xref="GOA:P50743" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR016484" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031166" /db_xref="InterPro:IPR032859" /db_xref="PDB:2HJG" /db_xref="PDB:4DCS" /db_xref="PDB:4DCT" /db_xref="PDB:4DCU" /db_xref="PDB:4DCV" /db_xref="PDB:4KYU" /db_xref="PDB:5X4B" /db_xref="SubtiList:BG11443" /db_xref="UniProtKB/Swiss-Prot:P50743" /translation="MGKPVVAIVGRPNVGKSTIFNRIAGERISIVEDTPGVTRDRIYS SAEWLNYDFNLIDTGGIDIGDEPFLAQIRQQAEIAMDEADVIIFMVNGREGVTAADEE VAKILYRTKKPVVLAVNKLDNTEMRANIYDFYSLGFGEPYPISGTHGLGLGDLLDAVA EHFKNIPETKYNEEVIQFCLIGRPNVGKSSLVNAMLGEERVIVSNVAGTTRDAVDTSF TYNQQEFVIVDTAGMRKKGKVYETTEKYSVLRALKAIDRSEVVAVVLDGEEGIIEQDK RIAGYAHEAGKAVVIVVNKWDAVDKDESTMKEFEENIRDHFQFLDYAPILFMSALTKK RIHTLMPAIIKASENHSLRVQTNVLNDVIMDAVAMNPTPTHNGSRLKIYYATQVSVKP PSFVVFVNDPELMHFSYERFLENRIRDAFGFEGTPIKIFARARK*" /label="der CDS" gene complement(1923905..1925215) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /label="der gene" S_feature complement(1925216..1925340) /Source="Nicolas_S_feature" /locus_tag="new_2391517_2391641_c" /HighExp="Cold, G180, G150, Oxctl, G135, C30, LBGexp, Paraq, dia0, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S864" promotor_-10 complement(1925326..1925345) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1925340) /Source="Nicolas_upshifts" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1925360..1925363) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1925369..1925563) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097755.1" /db_xref="EnsemblGenomes-Gn:BSU22849" /db_xref="EnsemblGenomes-Tr:CAX52654" /db_xref="UniProtKB/Swiss-Prot:C0H445" /translation="MSESLTKVILSVITTNRNRVAGGAPVFFCNDQKEMELFAKNLEA ILDGIAHRIGDDVYLIVKHF*" /label="ypzH CDS" gene complement(1925369..1925563) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /label="ypzH gene" CDS complement(1925560..1926453) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390166.1" /db_xref="EnsemblGenomes-Gn:BSU22850" /db_xref="EnsemblGenomes-Tr:CAB14201" /db_xref="GOA:P50742" /db_xref="InterPro:IPR025918" /db_xref="SubtiList:BG11442" /db_xref="UniProtKB/Swiss-Prot:P50742" /translation="MSDYIYPIIAGVIAGIATRLYMLKTDYRQYPTYVHGKVIHIALG LIAAGLGAIIMPALLQEEFTAITFLTLAATQFRDVRNMERNTLTQMDSYELVSRGSTY IEGIAIAFESRNYIVIFTALLTTSAYVFLSIWAAVIAAVVCFLLAMKFMSGSVLKDIV DIEYIKPRFDGPGLFVDNIYMMNIGLPEKQELILKHGMGFILTPKNFNSAATIANLGQ RQAILFDVSNVLGVYRDSGEPSLTPIAKRDLNDGRVAVFVLPQIHHPETAVQIISNVP TLENAIRMPTEFIKNQDKVIG*" /label="yphB CDS" gene complement(1925560..1926453) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /label="yphB gene" CDS complement(1926450..1927049) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390167.1" /db_xref="EnsemblGenomes-Gn:BSU22860" /db_xref="EnsemblGenomes-Tr:CAB14202" /db_xref="GOA:P50741" /db_xref="InterPro:IPR014617" /db_xref="SubtiList:BG11441" /db_xref="UniProtKB/Swiss-Prot:P50741" /translation="MEQFYYYWSMWFLWVLTTFIFEKTKRRIAVSVFILTNIILSIHD IALYFSLNAAYLMFFVCGCVYAGYLGMYRFRYIMVYLTLVAAYAFVYLFALYDPVWFI IKPEWAAVILIVLLTASVERNFEKQLVLFVLGMCQGELVYSFVIQKLAGAMAVGGFQW LNACSAGMILLFGISKYEHLASQIGQKSKRSNKGATKMS*" /label="yphA CDS" gene complement(1926450..1927049) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /label="yphA gene" promotor_-35 1926922..1926928 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1926937..1927120 /Source="Nicolas_S_feature" /locus_tag="new_2393238_2393421" /HighExp="S5, S8, S6, S7, BT, S4, ferm, nit, Pyr, G/S" /AntisenseName="yphA" /AntisenseCor="0.73324773408178501" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.6" /TUlongSig="NA" /TUlongPSig="NA" /label="S865" upshifts 1926939 /Source="Nicolas_upshifts" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1926942..1926953 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1927060..1927078) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1927079) /Source="Nicolas_upshifts" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1927094..1927099) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1927127..1927258 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="YP_003097756.2" /db_xref="EnsemblGenomes-Gn:BSU22869" /db_xref="EnsemblGenomes-Tr:CAX52655" /db_xref="InterPro:IPR025414" /db_xref="UniProtKB/Swiss-Prot:C0H446" /translation="MGKDRQEKKLKASGRVESDRDQSIHYDGATSLEQNGRFKKRKS* " /label="ypzI CDS" gene 1927127..1927258 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /label="ypzI gene" downshifts 1927246 /Source="Nicolas_upshifts" /id="D1191" /incds=0 /nref=37 /ntot=122 /MaxReadThrough="0.20384" /MaxDrop="6.94664" /score="3.33160455" /energy="-13.2" /TU="NA" /idTUdmin="U1785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1927301..1928350) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /EC_number="5.3.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12798687, 14745175, 15206931" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12798687, 14745175, 15206931; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl diphosphate isomerase (typeII)" /protein_id="NP_390168.3" /db_xref="EnsemblGenomes-Gn:BSU22870" /db_xref="EnsemblGenomes-Tr:CAB14203" /db_xref="GOA:P50740" /db_xref="InterPro:IPR000262" /db_xref="InterPro:IPR011179" /db_xref="InterPro:IPR013785" /db_xref="PDB:1P0K" /db_xref="PDB:1P0N" /db_xref="SubtiList:BG11440" /db_xref="UniProtKB/Swiss-Prot:P50740" /translation="MTRAERKRQHINHALSIGQKRETGLDDITFVHVSLPDLALEQVD ISTKIGELSSSSPIFINAMTGGGGKLTYEINKSLARAASQAGIPLAVGSQMSALKDPS ERLSYEIVRKENPNGLIFANLGSEATAAQAKEAVEMIGANALQIHLNVIQEIVMPEGD RSFSGALKRIEQICSRVSVPVIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSK IENLRRQRQISFFNSWGISTAASLAEIRSEFPASTMIASGGLQDALDVAKAIALGASC TGMAGHFLKALTDSGEEGLLEEIQLILEELKLIMTVLGARTIADLQKAPLVIKGETHH WLTERGVNTSSYSVR*" /label="fni CDS" gene complement(1927301..1928350) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /label="fni gene" downshifts complement(1927321) /Source="Nicolas_upshifts" /id="D1192" /incds=0 /nref=209 /ntot=250 /MaxReadThrough="1.39069" /MaxDrop="4.82362" /score="15.2467448" /energy="-13.2" /TU="NA" /idTUdmin="U1788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1928225) /Source="Nicolas_upshifts" /id="D1193" /incds=1 /nref=45 /ntot=237 /MaxReadThrough="6.15611" /MaxDrop="4.91722" /score="13.2731686" /energy="-15.7" /TU="U1788,U1789,U1790" /idTUdmin="U1788" /TUdmin="-904" /isTUend="FALSE" /label="downshifts" CDS complement(1928363..1929511) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 9862121, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA degradation presenting factor (ribosomal protein S1 homolog)" /protein_id="NP_390169.1" /db_xref="EnsemblGenomes-Gn:BSU22880" /db_xref="EnsemblGenomes-Tr:CAB14204" /db_xref="GOA:P38494" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11005" /db_xref="UniProtKB/Swiss-Prot:P38494" /translation="MTEEMNQIDVQVPEVGDVVKGIVTKVEDKHVDVEIINVKQSGII PISELSSLHVEKASDVVKVDDELDLKVTKVEDDALILSKRAVDADRAWEDLEKKFETK EVFEAEVKDVVKGGLVVDIGVRGFIPASLVEAHFVEDFTDYKGKTLSLLVVELDRDKN RVILSHRAVVESEQANKKQELLQSLEVGSVLDGKVQRLTDFGAFVDIGGIDGLVHISQ LSHSHVEKPSDVVEEGQEVKVKVLSVDRDNERISLSIKDTLPGPWNQIGEKVKPGDVL EGTVQRLVSFGAFVEILPGVEGLVHISQISNKHIGTPHEVLEEGQTVKVKVLDVNENE ERISLSMRELEETPKADQEDYRQYQAKEETSTGFQLGDLIGDKLNKLK*" /label="rpfA CDS" gene complement(1928363..1929511) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /label="rpfA gene" misc_feature 1928692..1928695 /Source="Nicolas_upshift_promotors" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1928719 /Source="Nicolas_upshifts" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1928785 /Source="Nicolas_upshifts" /id="D1194" /incds=1 /nref=1 /ntot=124 /MaxReadThrough="1.88188" /MaxDrop="2.8624" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1929489 /Source="Nicolas_upshifts" /id="D1195" /incds=0 /nref=3 /ntot=200 /MaxReadThrough="1.33117" /MaxDrop="3.08345" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=704 /isTUend="FALSE" /label="downshifts" S_feature complement(1929512..1929651) /Source="Nicolas_S_feature" /locus_tag="new_2395813_2395952_c" /HighExp="C90, Salt, Etha, Lbtran, HiOs, M40t90, S1, LBGtran, LoTm, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.999, 0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S866" promotor_-10 complement(1929650..1929669) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1929651) /Source="Nicolas_upshifts" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1929653..1929743) /Source="Nicolas_S_feature" /locus_tag="new_2395954_2396044_c" /HighExp="G135, G180, LBGexp, C30, Cold, Oxctl, dia0, G150, Paraq, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40511799999999998" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S867" promotor_-35 complement(1929684..1929691) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1929744..1930418) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /EC_number="2.7.4.25" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8576266, 9179491, 9862121, 11827479, 12682299, 16880539" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576266, 9179491, 9862121, 11827479, 12682299, 16880539; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidylate kinase" /protein_id="NP_390170.1" /db_xref="EnsemblGenomes-Gn:BSU22890" /db_xref="EnsemblGenomes-Tr:CAB14205" /db_xref="GOA:P38493" /db_xref="InterPro:IPR003136" /db_xref="InterPro:IPR011994" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11004" /db_xref="UniProtKB/Swiss-Prot:P38493" /translation="MEKKLSIAIDGPAAAGKSTVAKIVAEKKSYIYIDTGAMYRAITY AALQENVDLTDEEKLAELLKRTDIELITTKDGQKVFVNGTDVTEAIRTDEISNQVSIA AKHRSVREEMVKRQQQLGEKGGVVMDGRDIGTHVLPNAEVKIFLLASVEERAKRRYEE NVKKGFDVNYETLIEEIARRDKLDSEREVSPLRKAEDALEIDTTSLSIQEVADKILEA VEQKSR*" /label="cmk CDS" gene complement(1929744..1930418) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /label="cmk gene" S_feature complement(1930419..1930496) /Source="Nicolas_S_feature" /locus_tag="new_2396720_2396797_c" /HighExp="S4, S5, S7, S8, S6, dia15, S3, Diami, dia5, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S868" CDS complement(1930497..1930673) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390171.1" /db_xref="EnsemblGenomes-Gn:BSU22900" /db_xref="EnsemblGenomes-Tr:CAB14206" /db_xref="InterPro:IPR035281" /db_xref="SubtiList:BG11003" /db_xref="UniProtKB/Swiss-Prot:P38492" /translation="MKTFERLLIKLLFIQAIILLGVQFLFHYQHIEPYVSKVIQYEGV DKMEENNRIETFKH*" /label="ypfB CDS" gene complement(1930497..1930673) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /label="ypfB gene" promotor_-10 complement(1930685..1930703) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1930702) /Source="Nicolas_upshifts" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1930718..1930724) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1930718..1931371) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16249258, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16249258, 23893111, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic di-GMP receptor" /protein_id="NP_390172.1" /db_xref="EnsemblGenomes-Gn:BSU22910" /db_xref="EnsemblGenomes-Tr:CAB14207" /db_xref="GOA:P38491" /db_xref="InterPro:IPR009875" /db_xref="InterPro:IPR009926" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG11002" /db_xref="UniProtKB/Swiss-Prot:P38491" /translation="MIEIGENVLLEYIEENELKKAKSKAVSIENNELLIAYPVDVVTG RTVILHNDMEVTVEFVGKDEVPYRFISRIKGKVKDKLQMICLEMPPREKMKRIQRRQY VRTDAVLDVQIQPGNEEEIRTLSYNISAGGIAVVLADGLSFQSGESLRLIIRLPEEEH TRQIETEAVVRRIFNDPKSEKRKMTLEYSEIAAGDQQALLQYCIRRQLNKRRKARME* " /label="dgrA CDS" gene complement(1930718..1931371) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /label="dgrA gene" promotor_-10 complement(1931401..1931420) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1931414) /Source="Nicolas_upshifts" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1931436..1931440) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1931464..1932816) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination membrane component" /protein_id="NP_390173.1" /db_xref="EnsemblGenomes-Gn:BSU22920" /db_xref="EnsemblGenomes-Tr:CAB14208" /db_xref="GOA:P38490" /db_xref="InterPro:IPR014239" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG11001" /db_xref="UniProtKB/Swiss-Prot:P38490" /translation="MIRGILIAVLGIAIVGTGYWGYKEHQEKDAVLLHAENNYQRAFH ELTYQVDQLHDKIGTTLAMNSQKSLSPALIDVWRITSEAHNSVSQLPLTLMPFNKTEE LLSKIGDFSYKTSVRDLDQKPLDKNEYTSLNKLYQQSEDIQNELRHVQHLVMSKNLRW MDVEMALASDEKQSDNTIINSFKTVEKNVGAFSTGTDLGPSFTSTKKEEKGFSHLKGK QISEQEAKQIAERFAPDDNYSIKVVKSGKKTNRDVYSISMKDPDHKAVIYMDITKKGG HPVYLIQNREVKDQKISLNDGSNRALAFLKKNGFETDDLEIDESAQYDKIGVFSYVPV ENKVRMYPEAIRMKVALDDGEVVGFSARDFLTSHRKRTIPKPAITEAEAKSKLNKNVQ VRETRLALITNELGQEVLCYEMLGTIENDTFRMYINAKDGSEEKVEKLKNAEPIYKDL *" /label="sleC CDS" gene complement(1931464..1932816) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /label="sleC gene" downshifts complement(1931479) /Source="Nicolas_upshifts" /id="D1196" /incds=0 /nref=21 /ntot=44 /MaxReadThrough="0.647060000000002" /MaxDrop="5.74199" /score="16.6521528" /energy="-10.1" /TU="NA" /idTUdmin="U1791" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1932851..1933768) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination cortex-lytic enzyme" /protein_id="NP_390174.1" /db_xref="EnsemblGenomes-Gn:BSU22930" /db_xref="EnsemblGenomes-Tr:CAB14209" /db_xref="GOA:P50739" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR011105" /db_xref="InterPro:IPR014224" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11439" /db_xref="UniProtKB/Swiss-Prot:P50739" /translation="MKSKGSIMACLILFSFTITTFINTETISAFSNQVIQRGATGDDV VELQARLQYNGYYNGKIDGVYGWGTYWAVRNFQDQFGLKEVDGLVGAKTKQTLICKSK YYREYVMEQLNKGNTFTHYGKIPLKYQTKPSKAATQKARQQAEARQKQPAEKTTQKPK ANANKQQNNTPAKARKQDAVAANMPGGFSNNDIRLLAQAVYGEARGEPYEGQVAIAAV ILNRLNSPLFPNSVAGVIFEPLAFTAVADGQIYMQPNETAREAVLDAINGWDPSEEAL YYFNPDTATSPWIWGRPQIKRIGKHIFCE*" /label="sleB CDS" gene complement(1932851..1933768) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /label="sleB gene" downshifts complement(1933239) /Source="Nicolas_upshifts" /id="D1197" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.35344" /MaxDrop="4.29326" /score="-3.16364421" /energy="-21.7" /TU="U1791,U1792" /idTUdmin="U1793" /TUdmin=682 /isTUend="FALSE" /label="downshifts" misc_feature complement(1933390..1933397) /Source="Nicolas_upshift_promotors" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1933393) /Source="Nicolas_upshifts" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1933806..1933817) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1933815) /Source="Nicolas_upshifts" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1933831..1933837) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1933907..1934563) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease required for RsiW anti-sigma(W) degradation" /protein_id="NP_390175.1" /db_xref="EnsemblGenomes-Gn:BSU22940" /db_xref="EnsemblGenomes-Tr:CAB14210" /db_xref="GOA:P50738" /db_xref="InterPro:IPR023596" /db_xref="InterPro:IPR026898" /db_xref="SubtiList:BG11438" /db_xref="UniProtKB/Swiss-Prot:P50738" /translation="MFAIISAGIAPGIALLSYFYLKDQYDNEPVHMVLRSFFLGVVLV FPIMFIQYVLEKENVGGGSFFVSFLSSGFLEESLKWFILMISVYPHAHFDEHYDGIVY GASVSLGFATLENILYLIGHGVEHAFVRALLPVSCHALIGVIMGFYLGKARFSADKAR VKWLTLSLVVPSLLHGSYDFILTALSNWIYYMLPFMVFLWWFGLRKAKKARSVNMMQV *" /label="prsW CDS" gene complement(1933907..1934563) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /label="prsW gene" downshifts complement(1933921) /Source="Nicolas_upshifts" /id="D1198" /incds=0 /nref=239 /ntot=262 /MaxReadThrough="0.9181" /MaxDrop="6.61797" /score="-3.16364421" /energy="-21.7" /TU="NA" /idTUdmin="U1793" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1934588..1934607) /Source="Nicolas_upshift_promotors" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1934603) /Source="Nicolas_upshifts" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1934683..1935657) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /EC_number="1.8.-.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacillithiol biosynthesis thiol disulfide oxidoreductase" /protein_id="NP_390176.2" /db_xref="EnsemblGenomes-Gn:BSU22950" /db_xref="EnsemblGenomes-Tr:CAB14211" /db_xref="GOA:P50736" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR023856" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11436" /db_xref="UniProtKB/Swiss-Prot:P50736" /translation="MIQEKAIIIGGGPCGLSAAIHLKQIGIDALVIEKGNVVNSIYNY PTHQTFFSSSEKLEIGDVAFITENRKPVRIQALSYYREVVKRKNIRVNAFEMVRKVTK TQNNTFVIETSKETYTTPYCIIATGYYDHPNYMGVPGEDLPKVFHYFKEGHPYFDKDV VVIGGKNSSVDAALELVKSGARVTVLYRGNEYSPSIKPWILPEFEALVRNGTIRMEFG ACVEKITENEVVFRSGEKELITIKNDFVFAMTGYHPDHQFLEKIGVEIDKETGRPFFN EETMETNVEGVFIAGVIAAGNNANEIFIENGRFHGGHIAAEIAKRENH*" /label="ypdA CDS" gene complement(1934683..1935657) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /label="ypdA gene" downshifts complement(1934691) /Source="Nicolas_upshifts" /id="D1199" /incds=0 /nref=239 /ntot=263 /MaxReadThrough="3.524" /MaxDrop="6.45954" /score="27.4058676" /energy="-12.2" /TU="U1796" /idTUdmin="U1796" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-35 1935511..1935516 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1935532..1935550 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1935542..1935735 /Source="Nicolas_S_feature" /locus_tag="new_2401843_2402036" /HighExp="S8, S6, S7, S4, S5, C30, S3, BT, B36, C90" /AntisenseName="ypdA" /AntisenseCor="-0.487730736536516" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S869" upshifts 1935542 /Source="Nicolas_upshifts" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="upshifts" downshifts 1935693 /Source="Nicolas_upshifts" /id="D1200" /incds=0 /nref=13 /ntot=27 /MaxReadThrough="1.93985" /MaxDrop="5.69954" /score="23.7306175" /energy="-9.3" /TU="NA" /idTUdmin="U1794" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1935766..1937049) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 18326565, 22178969, 22720735, 25610436" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 18326565, 22178969, 22720735, 25610436; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cryptic glutamate dehydrogenase (active after removal of a 9 bp insert)" /protein_id="NP_390177.2" /db_xref="EnsemblGenomes-Gn:BSU22960" /db_xref="EnsemblGenomes-Tr:CAB14212" /db_xref="GOA:P50735" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K8Z" /db_xref="SubtiList:BG11435" /db_xref="UniProtKB/Swiss-Prot:P50735" /translation="MAADRNTGHTEEDKLDVLKSTQTVIHKALEKLGYPEEVYELLKE PMRLLTVKIPVRMDDGSVKIFTGYRAQHNDSVGPTKGGIRFHPNVTEKEVKAVKALSI WMSLKCGIIDLPYGGGKGGIVCDPRDMSFRELERLSRGYVRAISQIVGPTKDVPAPDV FTNSQIMAWMMDEYSRIDEFNSPGFITGKPLVLGGSHGRESATAKGVTICIKEAAKKR GIDIKGARVVVQGFGNAGSYLAKFMHDAGAKVVGISDAYGGLYDPEGLDIDYLLDRRD SFGTVTKLFNDTITNQELLELDCDILVPAAIENQITEENAHNIRAKIVVEAANGPTTL EGTKILSDRDILLVPDVLASAGGVTVSYFEWVQNNQGFYWSEEEVEEKLEKMMVKSFN NIYEMANNRRIDMRLAAYMVGVRKMAEASRFRGWI*" /label="gudB CDS" gene complement(1935766..1937049) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /label="gudB gene" downshifts complement(1935769) /Source="Nicolas_upshifts" /id="D1201" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="7.92262" /MaxDrop="4.04542" /score="18.1400723" /energy="-9.3" /TU="U1796" /idTUdmin="U1797" /TUdmin=1345 /isTUend="FALSE" /label="downshifts" promotor_-35 1935807..1935813 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1935825..1935829 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1935825 /Source="Nicolas_upshifts" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1937092..1937111) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1937113) /Source="Nicolas_upshifts" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1937126..1937133) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1937205..1937789) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914365, 19801546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914365, 19801546; Product type f: factor" /codon_start=1 /transl_table=11 /product="adaptor to ClpC; regulator of competence and sporulation" /protein_id="NP_390178.1" /db_xref="EnsemblGenomes-Gn:BSU22970" /db_xref="EnsemblGenomes-Tr:CAB14213" /db_xref="GOA:P50734" /db_xref="InterPro:IPR008681" /db_xref="PDB:3JTN" /db_xref="PDB:3JTO" /db_xref="SubtiList:BG11434" /db_xref="UniProtKB/Swiss-Prot:P50734" /translation="MRLERLNYNKIKIFLTLDDLTDRGLTKEDLWKDSFKVHQLFKDM MNEANTELGFEANGPIAVEVYSLQAQGMVVIVTKNQDADSEDDEYDDDYIEMQVKLDE SADIIYQFHSFEDIIQLSESLQRIGITGGTVYHYDGQYFLSLEDLGSHTAEGVVAVLA EYGNPTTLTIYRLQEYGKLIMDGNAVETIQTHFS*" /label="mecB CDS" gene complement(1937205..1937789) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /label="mecB gene" downshifts complement(1937207) /Source="Nicolas_upshifts" /id="D1202" /incds=0 /nref=258 /ntot=274 /MaxReadThrough="3.02006" /MaxDrop="7.92719" /score="23.8885529" /energy="-7.1" /TU="U1797" /idTUdmin="U1797" /TUdmin="-93" /isTUend="FALSE" /label="downshifts" S_feature complement(1937790..1937871) /Source="Nicolas_S_feature" /locus_tag="new_2404091_2404172_c" /HighExp="dia5, Diami, Etha, dia15, C90, Salt, LPhT, Heat, MG-0.2, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S870" promotor_-10 complement(1937864..1937883) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-10" upshifts complement(1937871) /Source="Nicolas_upshifts" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="upshifts" promotor_-35 complement(1937897..1937904) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-35" CDS complement(1937948..1938727) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 17434969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390179.1" /db_xref="EnsemblGenomes-Gn:BSU22980" /db_xref="EnsemblGenomes-Tr:CAB14214" /db_xref="GOA:P50733" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11433" /db_xref="UniProtKB/Swiss-Prot:P50733" /translation="MKLSVKIAGVLTVAAAAMTAKMYATAKGNHLKTHTFPLSKMKGK PPLTIFFISDIHKRLIDQDLLEKARSHAPHLVIIGGDLAEGGVPSARIEENIKRLVHF GVPIVFVWGNNDYEVRQHKLYSIFKAHGVITLRNESVPFSYNGHTIAIAGVDDIRMEM DHYEEAIKELDESQLNILVCHNPEIHEQINEDDGIDVILSGHTHGGQIRFGKFGPYEL GKTGIVKNAAYLISNGYGTTKVPLRLGAEPETHIVTLCGPE*" /label="ypbG CDS" gene complement(1937948..1938727) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /label="ypbG gene" promotor_-10 complement(1938753..1938768) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-10" upshifts complement(1938764) /Source="Nicolas_upshifts" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="upshifts" promotor_-35 complement(1938780..1938789) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-35" CDS complement(1938813..1939256) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390180.1" /db_xref="EnsemblGenomes-Gn:BSU22990" /db_xref="EnsemblGenomes-Tr:CAB14215" /db_xref="GOA:P50732" /db_xref="InterPro:IPR020210" /db_xref="SubtiList:BG11432" /db_xref="UniProtKB/Swiss-Prot:P50732" /translation="MESLWNQLDQFTDAPTKQMLQALVKRKQKFENYAAQCRRWRWAS LICLGLLCVMIMIKSPEPQLILQEILSHTFYLFWMLATAFAYCTSYYFKKKEEKSETD FHKLRCEIIQKSTDLWPQPDKWKARESVFHMMKHKYDINLYFESK*" /label="ypbF CDS" gene complement(1938813..1939256) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /label="ypbF gene" downshifts complement(1938830) /Source="Nicolas_upshifts" /id="D1203" /incds=0 /nref=4 /ntot=112 /MaxReadThrough="4.67294" /MaxDrop="3.33254" /score="6.86206051" /energy="-7.5" /TU="U1801" /idTUdmin="U1799" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1939319..1940041) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855244, 22950025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme possibly involved in cell wall turnover" /protein_id="NP_390181.1" /db_xref="EnsemblGenomes-Gn:BSU23000" /db_xref="EnsemblGenomes-Tr:CAB14216" /db_xref="GOA:P50731" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11431" /db_xref="UniProtKB/Swiss-Prot:P50731" /translation="MTNMSRVERRKAQNLYEDQNAALADDYVDDGESLPTRQSVKNQR EQKKKQGKTKTPLFTVLAVIFVFVPVIVLVTLFYLKSHPDNHDDYEDVFIDSSQSKYE VVPKSEDKNDTADTKETALQKESKKEPEDSKPKEQTAADKKQTAVAEKEDSPNKEEAT AAAASSSQSTVQQQEQPAEPVQNVPNRVVKHTVQKKETLYRISMKYYKSRTGEEKIRA YNHLNGNDVYTGQVLDIPLMDE*" /label="ypbE CDS" gene complement(1939319..1940041) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /label="ypbE gene" downshifts complement(1939600) /Source="Nicolas_upshifts" /id="D1204" /incds=1 /nref=4 /ntot=93 /MaxReadThrough="4.30678" /MaxDrop="3.33147" /score="6.86206051" /energy="-7.5" /TU="U1799,U1801" /idTUdmin="U1799" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" CDS complement(1939992..1940561) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390182.1" /db_xref="EnsemblGenomes-Gn:BSU23010" /db_xref="EnsemblGenomes-Tr:CAB14217" /db_xref="GOA:P50730" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG11430" /db_xref="UniProtKB/Swiss-Prot:P50730" /translation="MTQLLIIFAAAAAGLFFFEDVRDVLKLWDIRDMRIIWYGVSIAV IVILADMAVMKWFPSHLYDDGGINKKIFSKRSIPHIIFLTLLIAFAEEMLFRGVLQTH IGLWTASLIFAALHFRYLSKWLLFIMVTAISFLLGLMYEWTGNLFVPMTAHFIIDAVF ACQIRFEHVRRDKHDEHVESREKKSPESL*" /label="ypbD CDS" gene complement(1939992..1940561) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /label="ypbD gene" promotor_-10 complement(1940310..1940328) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1940326) /Source="Nicolas_upshifts" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1940343..1940349) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1940580..1941326 /Source="Nicolas_S_feature" /locus_tag="new_2406881_2407627" /HighExp="S6, S8, S7, C30, BT, S5, C90, Pyr, BC, Sw" /AntisenseName="recQ" /AntisenseCor="-0.47918253719211501" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S871" CDS complement(1940621..1942111) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16385024, 25246477, 26001966, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385024, 25246477, 26001966, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_390183.1" /db_xref="EnsemblGenomes-Gn:BSU23020" /db_xref="EnsemblGenomes-Tr:CAB14218" /db_xref="GOA:P50729" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002464" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11407" /db_xref="UniProtKB/Swiss-Prot:P50729" /translation="MTKLQQTLYQFFGFTSFKKGQQDIIESILSGKDTIAMLPTGGGK SLCYQLPGYMLDGMVLIVSPLLSLMEDQVQQLKARGEKRAAALNSMLNRQERQFVLEH IHRYKFLYLSPEALQSPYVLEKLKSVPISLFVIDEAHCISEWGHDFRPDYSKLGQLRK KLGHPPVLALTATATKETLQDVMNLLELQHAVRHLNSVNRPNIALRVENAADTAEKID RVIQLVENLQGPGIVYCPTRKWAKELAGEIKSKTSSRADFYHGGLESGDRILIQQQFI HNQLDVICCTNAFGMGVDKPDIRYVIHFHLPQTAEAFMQEIGRAGRDGKPSVSILLRA PGDFELQEQIIQMESVTAEEIADVIRVLEKTEERDERRLRDVLLQYGVGETQARMMIH LFMQGKTSVELMKKEISYRMELKLEKMHRVSFLLQRDGCLRQALLTYFDESYEPDDGN LPCCSHCGFDLSLYEQKGERSKMAPLDSWSSELHRIFSLQTVGELN*" /label="recS CDS" gene complement(1940621..1942111) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /label="recS gene" CDS complement(1942104..1943162) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /experiment="publication(s) with functional evidences, PMID:21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21170359; Product type f: factor" /codon_start=1 /transl_table=11 /product="subunit of the platform for genome maintenance machinery" /protein_id="NP_390184.1" /db_xref="EnsemblGenomes-Gn:BSU23030" /db_xref="EnsemblGenomes-Tr:CAB14219" /db_xref="InterPro:IPR008308" /db_xref="InterPro:IPR029491" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11429" /db_xref="UniProtKB/Swiss-Prot:P50728" /translation="MSLNYFDIMVLDCLCKINGERSGSAVFHLFKGKRSSQTIQDAGL FQTAKYFGMAAKCSRSDISASLDKLEKHSYLAPMSESDTYKVTASGAAVLRHALSERP WPVHCHGAHYQQAAGVLWKRLSLLVQVLSHKQQGSRQYIPVTKDHKTLHWVKKYLSRH TDHIEMAKSLFAMLEAHLKKIENKAAQIFVYSLTSHHRIGYTSRQLADTLKEDEWYVY IMFWASVHYFIHSLPECEDALLKDLLSDVHLDNALTESTRKTWQMVKQGFPIQRIAEI RKLKTATIEDHIVEISLHEPAFMINDYVSAEDQLQIAEFAKRMRTNKIKQIRDGLEQR FSYFQIRLALTKQVQQYD*" /label="gmmB CDS" gene complement(1942104..1943162) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /label="gmmB gene" promotor_-35 1942452..1942461 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1942472..1943262 /Source="Nicolas_S_feature" /locus_tag="new_2408773_2409563" /HighExp="S8, S6, S7, S5, BT, B36, Pyr, G/S, B60, nit" /AntisenseName="ypbB" /AntisenseCor="-0.76734368116597995" /AntisenseRegPval="-52.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S872" upshifts 1942472 /Source="Nicolas_upshifts" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1942474..1942493 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1943203..1943222) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1943226) /Source="Nicolas_upshifts" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1943234..1943241) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1943240..1943246 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-35" promotor_-10 1943260..1943279 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-10" S_feature 1943264..1943333 /Source="Nicolas_S_feature" /locus_tag="new_2409565_2409634" /HighExp="S6, S8, S7, S5, BT, B36, C30, Pyr, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="0.991, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S873" upshifts 1943264 /Source="Nicolas_upshifts" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="upshifts" promotor_-35 1943313..1943320 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1943335..1943427 /Source="Nicolas_S_feature" /locus_tag="new_2409636_2409728" /HighExp="LPhT, LBGstat, HPh, C90, LBGtran, C30, Lbtran, Cold, LPh, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.996" /TUlongSig="SigB" /TUlongPSig="0.991" /label="S874" promotor_-10 1943335..1943354 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1943335 /Source="Nicolas_upshifts" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="upshifts" CDS 1943428..1943676 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12538057, 21665975" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12538057, 21665975; Product type c: carrier" /codon_start=1 /transl_table=11 /product="ferredoxin" /protein_id="NP_390185.1" /db_xref="EnsemblGenomes-Gn:BSU23040" /db_xref="EnsemblGenomes-Tr:CAB14220" /db_xref="GOA:P50727" /db_xref="InterPro:IPR001080" /db_xref="InterPro:IPR017896" /db_xref="SubtiList:BG11388" /db_xref="UniProtKB/Swiss-Prot:P50727" /translation="MAKYTIVDKDTCIACGACGAAAPDIYDYDDEGIAFVTLDENKGV VEVPEVLEEDMIDAFEGCPTDSIKVADEPFEGDPLKFE*" /label="fer CDS" gene 1943428..1943676 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /label="fer gene" downshifts 1943660 /Source="Nicolas_upshifts" /id="D1205" /incds=0 /nref=221 /ntot=291 /MaxReadThrough="3.16016" /MaxDrop="8.38074" /score="34.9672707" /energy="-9.9" /TU="U1803" /idTUdmin="U1800" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1943716..1944288) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12456892, 15849754, 16850406, 17693491, 25438558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15849754, 16850406, 17693491, 25438558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="FMN permease" /protein_id="NP_390186.1" /db_xref="EnsemblGenomes-Gn:BSU23050" /db_xref="EnsemblGenomes-Tr:CAB14237" /db_xref="GOA:P50726" /db_xref="InterPro:IPR024529" /db_xref="InterPro:IPR025720" /db_xref="SubtiList:BG11428" /db_xref="UniProtKB/Swiss-Prot:P50726" /translation="MKVKKLVVVSMLSSIAFVLMLLNFPFPGLPDYLKIDFSDVPAII AILIYGPLAGIAVEAIKNVLQYIIQGSMAGVPVGQVANFIAGTLFILPTAFLFKKLNS AKGLAVSLLLGTAAMTILMSILNYVLILPAYTWFLHSPALSDSALKTAVVAGILPFNM IKGIVITVVFSLIFIKLKPWIEQQRSAHIH*" /label="fmnP CDS" gene complement(1943716..1944288) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /label="fmnP gene" downshifts complement(1943736) /Source="Nicolas_upshifts" /id="D1206" /incds=0 /nref=103 /ntot=231 /MaxReadThrough="2.60651" /MaxDrop="4.95518" /score="35.0684207" /energy="-9.9" /TU="NA" /idTUdmin="U1804" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(1944280..1944587) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /product="flavin mononucleotide riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508; Product type n: RNA" /label="fswB RNA" gene complement(1944280..1944587) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /label="fswB gene" S_feature complement(1944289..1944393) /Source="Nicolas_S_feature" /locus_tag="new_2410590_2410694_c" /HighExp="S1, LPhT, M9-stat, B60, Heat, T0.30H, Gly, S5, BC, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S875" promotor_-10 complement(1944586..1944605) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1944602) /Source="Nicolas_upshifts" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1944619..1944625) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1944714..1944721 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1944732 /Source="Nicolas_upshifts" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1944736..1944755 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1944785..1946362 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /EC_number="1.1.1.95" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoglycerate dehydrogenase" /protein_id="NP_390188.2" /db_xref="EnsemblGenomes-Gn:BSU23070" /db_xref="EnsemblGenomes-Tr:CAB14239" /db_xref="GOA:P35136" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR006236" /db_xref="InterPro:IPR029009" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10509" /db_xref="UniProtKB/Swiss-Prot:P35136" /translation="MFRVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDELHTFDAL LVRSATKVTEDLFNKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEH TFAMISSLMRHIPQANISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAF GMTVHVFDPFLTEERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKT KKGVRLINCARGGIIDEAALLEALENGHVAGAALDVFEVEPPVDNKLVDHPLVIATPH LGASTKEAQLNVAAQVSEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQIAGKIGS LVSQCMKEPVQDVAIQYEGTIAKLETSFITKALLSGFLKPRVDSTVNEVNAGGVAKER GISFSEKISSSESGYDNCISVKVTGDRSTFTVTATYIPHFGERIVEINGFNIDFYPTG HLVYIQHQDTTGVIGRVGRILGDNDINIATMQVGRKEKGGEAIMMLSFDRHLEDKIVK ELTNVPDIVSVKLIDLP*" /label="serA CDS" gene 1944785..1946362 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /label="serA gene" downshifts 1946344 /Source="Nicolas_upshifts" /id="D1207" /incds=0 /nref=246 /ntot=311 /MaxReadThrough="3.23011" /MaxDrop="8.29454" /score="32.0086708" /energy="-10.2" /TU="U1805" /idTUdmin="U1805" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(1946405..1947172) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6442253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6442253; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase" /protein_id="NP_390189.1" /db_xref="EnsemblGenomes-Gn:BSU23080" /db_xref="EnsemblGenomes-Tr:CAB14240" /db_xref="GOA:P35146" /db_xref="InterPro:IPR001381" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018508" /db_xref="SubtiList:BG10538" /db_xref="UniProtKB/Swiss-Prot:P35146" /translation="MNVLTIKGVSIGEGMPKIIIPLMGKTEKQILNEAEAVKLLNPDI VEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLE SAIQTKDIDLIDIELFSGDANVKALVSLAEENNVYVVMSNHDFEKTPVKDEIISRLRK MQDLGAHIPKMAVMPNDTGDLLTLLDATYTMKTIYADRPIITMSMAATGLISRLSGEV FGSACTFGAGEEASAPGQIPVSELRSVLDILHKNTRG*" /label="aroC CDS" gene complement(1946405..1947172) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /label="aroC gene" downshifts complement(1946420) /Source="Nicolas_upshifts" /id="D1208" /incds=0 /nref=152 /ntot=231 /MaxReadThrough="2.53428" /MaxDrop="5.12103" /score="24.3727755" /energy="-10.2" /TU="NA" /idTUdmin="U1806" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1946674..1947286 /Source="Nicolas_S_feature" /locus_tag="new_2412975_2413587" /HighExp="B36, C30, LoTm, B60, C90, HiOs, BI, Sw, T1.0H, BT" /AntisenseName="aroC" /AntisenseCor="4.7354591214804703E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S876" promotor_-10 complement(1947199..1947218) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1947212) /Source="Nicolas_upshifts" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1947233..1947236) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1947246 /Source="Nicolas_upshifts" /id="D1209" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="2.02363" /MaxDrop="5.64228" /score="10.7892325" /energy="-8.5" /TU="NA" /idTUdmin="U1805" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS complement(1947284..1948390) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9139908, 9393439, 10712692, 14762009, 16306698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139908, 9393439, 10712692, 14762009, 16306698; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma(X) activity" /protein_id="NP_390190.2" /db_xref="EnsemblGenomes-Gn:BSU23090" /db_xref="EnsemblGenomes-Tr:CAB14241" /db_xref="GOA:P35166" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10537" /db_xref="UniProtKB/Swiss-Prot:P35166" /translation="MMKSEWNEEQIKELLSQLPAVKDHRSPQDIYKRLTMAKRKNKPA VRWIGPACAAAIAVYIAFIISPHFFDQAQPQQKEASQENAVTKTETEDSPKAASSLDQ TSFVVPEKEQDNYITVAVADADTSAIIPVSIQKTNADQTIQDMLFESSELGILDHAIT IPTFIDEVEIKEKPKQKELSIRVHQPATAFSIKDDTLLKKLLKESLKWSPYEKVKFLS DQNETGVRIGSYGTFTEISIPKQSKRSYYLYQNKQGQDFLVPSNHSFDTVKEAIKEME SSSQEDTTPLIQAGAVQSVTKKQKHLYIRFSKESEVDDSIAGILMIEGLLLTAKEFGF TEVTFTETRTKKIGKYDISDAIPVPAAPNPISLN*" /label="rsiX CDS" gene complement(1947284..1948390) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /label="rsiX gene" downshifts complement(1947301) /Source="Nicolas_upshifts" /id="D1210" /incds=0 /nref=155 /ntot=242 /MaxReadThrough="3.84557" /MaxDrop="5.30684" /score="7.9467954" /energy="-6.7" /TU="U1809" /idTUdmin="U1806" /TUdmin="-881" /isTUend="FALSE" /label="downshifts" CDS complement(1948326..1948910) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9636707, 11222589, 12399481, 14762009, 19767430, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9636707, 11222589, 12399481, 14762009, 19767430, 27965645; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor sigma(X)" /protein_id="NP_390191.2" /db_xref="EnsemblGenomes-Gn:BSU23100" /db_xref="EnsemblGenomes-Tr:CAB14242" /db_xref="GOA:P35165" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10536" /db_xref="UniProtKB/Swiss-Prot:P35165" /translation="MEETFQLLYDTYHQDLYQFLFYMVKDKNQTEDLLQEVYIRVLNS YHTFEGRSSEKTWLLSIARHVAIDWFRKQQTIRQRILGTFDWDTQDVRDQQLLPDELA VQHENVREIYAALDQCTIDQRAVIILRFIQGYSIQETAKALRFSESKVKTTQHRGLKV LRKHMELLREELMDDEVRMERRTDKGVVKSTSGS*" /label="sigX CDS" gene complement(1948326..1948910) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /label="sigX gene" promotor_-35 1948704..1948709 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1948720 /Source="Nicolas_upshifts" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1948724..1948728 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1948861..1948866 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1948878 /Source="Nicolas_upshifts" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1948882..1948900 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1948918 /Source="Nicolas_upshifts" /id="D1211" /incds=0 /nref=8 /ntot=81 /MaxReadThrough="5.89234" /MaxDrop="4.38483" /score="6.57298987" /energy="-13.5" /TU="U1808" /idTUdmin="U1807" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1948959..1948978) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1948963..1949070 /Source="Nicolas_S_feature" /locus_tag="new_2415264_2415371" /HighExp="S4, S8, S6, S7, C30, S3, LoTm, B60, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S877" upshifts complement(1948967) /Source="Nicolas_upshifts" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1948991..1948998) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1949026 /Source="Nicolas_upshifts" /id="D1212" /incds=0 /nref=12 /ntot=64 /MaxReadThrough="2.08559" /MaxDrop="4.36303" /score="6.57298987" /energy="-13.5" /TU="NA" /idTUdmin="U1808" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(1949055..1949113) /Source="Nicolas_S_feature" /locus_tag="new_2415356_2415414_c" /HighExp="Lbstat, BI, nit, S0, M40t90, Lbtran, M0t90, G135, Sw, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S878" downshifts complement(1949086) /Source="Nicolas_upshifts" /id="D1213" /incds=0 /nref=156 /ntot=252 /MaxReadThrough="2.62215" /MaxDrop="6.99198" /score="33.3049318" /energy="-13.5" /TU="NA" /idTUdmin="U1810" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1949114..1950883) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase (ResD / ResE)" /protein_id="NP_390192.1" /db_xref="EnsemblGenomes-Gn:BSU23110" /db_xref="EnsemblGenomes-Tr:CAB14243" /db_xref="GOA:P35164" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4ZR7" /db_xref="SubtiList:BG10535" /db_xref="UniProtKB/Swiss-Prot:P35164" /translation="MKFWKSVVGKLWFTILSLVLIVLFILTVLLLEFIENYHVEEAEN DLTQLANKVAVILENHEDQALARSITWELADNLTSIAIIQDEKNHWYSPNDKNRLSSI TVEQIQHDKDLNKALKDHKKVSKRTGLSDTDTDNERLIVGVPYEKDGKKGMVFLSQSL LAVKDTTKHTTRYIFLAAGIAIVLTTFFAFFLSSRVTYPLRKMREGAQDLAKGKFDTK IPILTQDEIGELATAFNQMGRQLNFHINALNQEKEQLSNILSSMADGVITINIDGTIL VTNPPAERFLQAWYYEQNMNIKEGDNLPPEAKELFQNAVSTEKEQMIEMTLQGRSWVL LMSPLYAESHVRGAVAVLRDMTEERRLDKLREDFIANVSHELRTPISMLQGYSEAIVD DIASSEEDRKEIAQIIYDESLRMGRLVNDLLDLARMESGHTGLHYEKINVNEFLEKII RKFSGVAKEKNIALDHDISLTEEEFMFDEDKMEQVFTNLIDNALRHTSAGGSVSISVH SVKDGLKIDIKDSGSGIPEEDLPFIFERFYKADKARTRGRAGTGLGLAIVKNIVEAHN GSITVHSRIDKGTTFSFYIPTKR*" /label="resE CDS" gene complement(1949114..1950883) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /label="resE gene" downshifts complement(1949170) /Source="Nicolas_upshifts" /id="D1214" /incds=0 /nref=5 /ntot=13 /MaxReadThrough="7.56028" /MaxDrop="3.58685" /score="33.3049318" /energy="-13.5" /TU="U1810,U1811,U1812" /idTUdmin="U1810" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(1950880..1951602) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator (ResD / ResE)" /protein_id="NP_390193.2" /db_xref="EnsemblGenomes-Gn:BSU23120" /db_xref="EnsemblGenomes-Tr:CAB14244" /db_xref="GOA:P35163" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10534" /db_xref="UniProtKB/Swiss-Prot:P35163" /translation="MDQTNETKILVVDDEARIRRLLRMYLERENYAIDEAENGDEAIA KGLEANYDLILLDLMMPGTDGIEVCRQIREKKATPIIMLTAKGEEANRVQGFEAGTDD YIVKPFSPREVVLRVKALLRRASQTSYFNANTPTKNVLVFSHLSIDHDAHRVTADGTE VSLTPKEYELLYFLAKTPDKVYDREKLLKEVWQYEFFGDLRTVDTHVKRLREKLNKVS PEAAKKIVTVWGVGYKFEVGAE*" /label="resD CDS" gene complement(1950880..1951602) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /label="resD gene" S_feature complement(1951603..1951682) /Source="Nicolas_S_feature" /locus_tag="new_2417904_2417983_c" /HighExp="Lbstat, M0t90, ferm, M40t90, S2, S0, nit, M40t45, BI, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S879" CDS complement(1951683..1952858) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10844653, 12682299, 15849754, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844653, 12682299, 15849754, 16850406, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390194.2" /db_xref="EnsemblGenomes-Gn:BSU23130" /db_xref="EnsemblGenomes-Tr:CAB14245" /db_xref="GOA:P35162" /db_xref="InterPro:IPR002541" /db_xref="InterPro:IPR017562" /db_xref="SubtiList:BG10533" /db_xref="UniProtKB/Swiss-Prot:P35162" /translation="MAELSGNFLYAAFLVYLIAVPIFGGAIRGNKDKKGRPNRWANIG ITLSIVGFFCHLGYFITRWAASGHAPVSNMFEFTTAFGMMLVLAFIILYFLYRLPSLG LFTLSIALLLIAYASMFPTDISPLIPSLQSNWLYIHVTTAALGQAILAISFVAGVIFL LKHVDQTKPSKKTFWLEAIMFILVTTVAFIAITSAFRLAGYEAEFNWVDKSKEKSVMV YEMPALVGPHQGELLTEGRMEPLVDLPALFSGRKVNTVIWSFGAGLVLYGALRLIIRK RISALLHPLVKNVNLDLVDEVGYRAVSIGFPIFTLGALIFAMIWAQLAWTRFWGWDPK EVWALITFLFYAAYLHLRLSRGWHGEKSAWLAVIGFAIIMFNLIFVNLVLAGLHSYA* " /label="resC CDS" gene complement(1951683..1952858) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /label="resC gene" CDS complement(1952878..1954506) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9395519, 10844653, 12682299, 16825793, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9395519, 10844653, 12682299, 16825793, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390195.1" /db_xref="EnsemblGenomes-Gn:BSU23140" /db_xref="EnsemblGenomes-Tr:CAB14246" /db_xref="GOA:P35161" /db_xref="InterPro:IPR007816" /db_xref="SubtiList:BG10532" /db_xref="UniProtKB/Swiss-Prot:P35161" /translation="MKQVKCECGHINPVGTVLCESCGRALQETQPPLADMRYDGSARR SQTYNKTIIDKIWNFFSSVKVGIWLIVITLAASAFGTIFPQEAYLPPGAQADTYYKEQ YGTFGQLYYLLGFHHLYGSWWYLLLIASIGISLVICSLDRVIPLYRALKNQGVRRSPA FLRRQRLFSETVTVLNGESKEKIVTLLKKKHYRIREKEGSILAEKGRFSRWGPYVNHI GLIIFLIGAMLRFVPGMYVDETLWVREGETAAIPGTDGKYYLKNNQFSVETYNSKTEK KVFADAIDRVGDGRVAKNFQTDAVLYKREGKIVYGEKPKLEKVTEEDIRVNQPLRFDS FSVYQVDYKENQLDQMVFQLIDKKTKKSFGSLKINLLDPDSVYDLGNGYKVEIASYLP DFYFNQDGEPSTKTKIPNNPAFVFNIITPDKPKGEKSFVAIQETIEGSGNNKYKLKFD HVETKNITGLTVRKDLTLWVLAVGGAIFMIGVIQGMYWQHRRIWLHSQDGAVMVAGHT NKNWFGLKKDLAFILADSGLTEPVDQKELIKTQK*" /label="resB CDS" gene complement(1952878..1954506) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /label="resB gene" CDS complement(1954503..1955042) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracytoplasmic thioredoxin involved in cytochrome c maturation (lipoprotein)" /protein_id="NP_390196.2" /db_xref="EnsemblGenomes-Gn:BSU23150" /db_xref="EnsemblGenomes-Tr:CAB14247" /db_xref="GOA:P35160" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR023555" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ST9" /db_xref="PDB:1SU9" /db_xref="PDB:2F9S" /db_xref="PDB:2H19" /db_xref="PDB:2H1A" /db_xref="PDB:2H1B" /db_xref="PDB:2H1D" /db_xref="PDB:2H1G" /db_xref="PDB:3C71" /db_xref="PDB:3C73" /db_xref="SubtiList:BG10531" /db_xref="UniProtKB/Swiss-Prot:P35160" /translation="MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPN FVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKEFPYMANQYKHFKSQGVEIVAVN VGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTM TESMIHDYMNLIKPGETSG*" /label="resA CDS" gene complement(1954503..1955042) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /label="resA gene" S_feature complement(1955043..1955136) /Source="Nicolas_S_feature" /locus_tag="new_2421344_2421437_c" /HighExp="LBGtran, LBGstat, G180, Oxctl, H2O2, G150, M0t90, G135, Paraq, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S880" CDS complement(1955137..1955871) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /EC_number="4.2.1.70" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9888802, 24214967" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888802, 24214967; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA pseudouridine 2633 (=2605 standard) pseudouridine synthase" /protein_id="NP_390197.2" /db_xref="EnsemblGenomes-Gn:BSU23160" /db_xref="EnsemblGenomes-Tr:CAB14248" /db_xref="GOA:P35159" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10530" /db_xref="UniProtKB/Swiss-Prot:P35159" /translation="MERLQKVIAHAGVASRRKAEELIKEGKVKVNGKVVTELGVKVTG SDQIEVNGLKVEREEPVYFLLYKPRGVISAAQDDKGRKVVTDFFKNIPQRIYPIGRLD YDTSGLLLLTNDGEFANKLMHPKYEIDKTYVAKVKGIPPKELLRKLERGIRLEEGKTA PAKAKLLSLDKKKQTSIIQLTIHEGRNRQVRRMFEAIGHEVIKLKREEYAFLNLRGLH TGDARELTPHEVKRLRALADHGKNAF*" /label="rluB CDS" gene complement(1955137..1955871) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /label="rluB gene" promotor_-10 complement(1955880..1955899) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1955903) /Source="Nicolas_upshifts" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1955914..1955918) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1955963..1956499) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390198.2" /db_xref="EnsemblGenomes-Gn:BSU23170" /db_xref="EnsemblGenomes-Tr:CAB14249" /db_xref="GOA:P35158" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10529" /db_xref="UniProtKB/Swiss-Prot:P35158" /translation="MEIINWLSLAMIPIIIAGILLYGTIKKVPTYESFVEGGKEGIEI AFSIIPYLVGMLVAITVFRSSGALDFIMDLLKPAFSAIGIPAEVVPLALIRPISGTAA LGMTTDLIAVYGPDSFIGRLASVMQGSTDTTLYVLTVYFGAVGIKKMGDALKVGLLAD LIGVVASIIIVTLLFGSA*" /label="spmB CDS" gene complement(1955963..1956499) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /label="spmB gene" promotor_-10 complement(1955968..1955987) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1955972) /Source="Nicolas_upshifts" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1956002..1956009) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1956504..1957094) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390199.1" /db_xref="EnsemblGenomes-Gn:BSU23180" /db_xref="EnsemblGenomes-Tr:CAB14250" /db_xref="GOA:P35157" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10528" /db_xref="UniProtKB/Swiss-Prot:P35157" /translation="MVNIIWVSLTVIGLVFAMCNGTLQDVNEAVFKGAKEAITISFGL MSVLVFWLGLMKIAEQSGLLDIFSRMCRPFISKLFPDIPPDHPAMGYILSNLMANFFG LGNAATPLGIKAMEQMKKLNGNRSEASRSMITFLAVNTSCITLIPTTVIAVRMAYSSK TPTDIVGPSILATLISGIGAIIIDRYFYYRRKKKGR*" /label="spmA CDS" gene complement(1956504..1957094) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /label="spmA gene" CDS complement(1957082..1958230) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /EC_number="3.4.16.4" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 8892816, 9864321, 10498740, 18266856, 19542328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 8892816, 9864321, 10498740, 18266856, 19542328; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5*) (required for spore cortex)" /protein_id="NP_390200.1" /db_xref="EnsemblGenomes-Gn:BSU23190" /db_xref="EnsemblGenomes-Tr:CAB14251" /db_xref="GOA:P35150" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR018044" /db_xref="PDB:3MFD" /db_xref="SubtiList:BG10527" /db_xref="UniProtKB/Swiss-Prot:P35150" /translation="MRIFKKAVFVIMISFLIATVNVNTAHAAIDVSAKSAIIIDGASG RVLYAKDEHQKRRIASITKIMTAVLAIESGKMDQTVTVSANAVRTEGSAIYLTEGQKV KLKDLVYGLMLRSGNDAAVAIAEHVGGSLDGFVYMMNQKAEQLGMKNTRFQNPHGLDD HENHYSTAYDMAILTKYAMKLKDYQKISGTKIYKAETMESVWKNKNKLLTMLYPYSTG GKTGYTKLAKRTLVSTASKDGIDLIAVTINDPNDWDDHMKMFNYVFEHYQTYLIAKKG DIPKLKGTFYESKAFIKRDITYLLTEEEKENVKINTTLLKPKKAWEKDASKIPDIVGH MEIMFNDATIAKVPIYYENERHQKPKKQFFETFKSIFLNAAGGAKWSI*" /label="dacB CDS" gene complement(1957082..1958230) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /label="dacB gene" promotor_-10 complement(1958252..1958270) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1958259) /Source="Nicolas_upshifts" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1958285..1958290) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1958353..1958892) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12065423" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390201.1" /db_xref="EnsemblGenomes-Gn:BSU23200" /db_xref="EnsemblGenomes-Tr:CAB14252" /db_xref="InterPro:IPR025013" /db_xref="SubtiList:BG10526" /db_xref="UniProtKB/Swiss-Prot:P35156" /translation="MKEAKCERQIHEGKIPNEMGHSIVRAQTQKTGEFLSMVVNTVND YLNQTTLESLQAELPIEKGYCCDVLSTLRRMAVFCEGGAEACRRLLMQEPFQEARAEK TLYNVYHQCIEEFFMPKKDTWCENSRASYTGVSAIEFYHAVPASLEQLLLPLSAAFLK MREELAHYEASGSSMAPIR*" /label="ypuI CDS" gene complement(1958353..1958892) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /label="ypuI gene" downshifts complement(1958366) /Source="Nicolas_upshifts" /id="D1215" /incds=0 /nref=219 /ntot=260 /MaxReadThrough="1.63638" /MaxDrop="8.00748" /score="36.7302977" /energy="-12.2" /TU="NA" /idTUdmin="U1813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1958901..1958918) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1958916) /Source="Nicolas_upshifts" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1958933..1958938) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1958947..1959540) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation factor" /protein_id="NP_390202.1" /db_xref="EnsemblGenomes-Gn:BSU23210" /db_xref="EnsemblGenomes-Tr:CAB14253" /db_xref="GOA:P35155" /db_xref="InterPro:IPR005234" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10525" /db_xref="UniProtKB/Swiss-Prot:P35155" /translation="MGLDIVNWKAIVEALLYAAGDEGLTKKQLLTVLEIEEPELNTIM ADVADEYRGDTRGIELIEYADTYMLSTKKDFAPYLKKLIEVPSKGLSQASLEVLAIVS YKQPITRAEIEEIRGVKSERILHSLVAKALLCEVGRADGPGRAILYGTTPTFLEQFGL KTLDELPPLPENAEEDVLQEEADLFFENFNQTFEDIK*" /label="spcB CDS" gene complement(1958947..1959540) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /label="spcB gene" CDS complement(1959530..1960285) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and partitioning factor" /protein_id="NP_390203.1" /db_xref="EnsemblGenomes-Gn:BSU23220" /db_xref="EnsemblGenomes-Tr:CAB14254" /db_xref="GOA:P35154" /db_xref="InterPro:IPR003768" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG10524" /db_xref="UniProtKB/Swiss-Prot:P35154" /translation="MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLY VHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLI EYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKV LKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFL AVLELMKNQLVLIEQEHNFSDIYITGSESIHGA*" /label="scpA CDS" gene complement(1959530..1960285) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /label="scpA gene" promotor_-35 1960129..1960138 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1960151..1960170 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1960160 /Source="Nicolas_upshifts" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1960331..1960350) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1960346) /Source="Nicolas_upshifts" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1960364..1960371) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1960511..1960518 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1960529..1960548 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1960534 /Source="Nicolas_upshifts" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="upshifts" CDS 1960566..1961090 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390204.1" /db_xref="EnsemblGenomes-Gn:BSU23230" /db_xref="EnsemblGenomes-Tr:CAB14255" /db_xref="InterPro:IPR005500" /db_xref="InterPro:IPR023203" /db_xref="SubtiList:BG10523" /db_xref="UniProtKB/Swiss-Prot:P17617" /translation="MYPKAYIDYLVEFHATRDYFECHEILEEYWKEDPPKKRKRYWVG FIQLAVALYHHRRQNTAGAKRLMANSIRILQAEHRAVEDLGLDHGRLLELMQSVYEQI ETVSAYKSIILPIKDEKLEEACRIECRKKKYTWGQPSALSNIFLIDKHRLRDRTDVIR EREKEIERRKKSRD*" /label="ypuF CDS" gene 1960566..1961090 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /label="ypuF gene" CDS complement(1961104..1961478) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15466513, 25349719; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative riboflavin synthesis-related N-acetyltransferase" /protein_id="NP_390205.1" /db_xref="EnsemblGenomes-Gn:BSU23240" /db_xref="EnsemblGenomes-Tr:CAB14256" /db_xref="GOA:P17622" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10522" /db_xref="UniProtKB/Swiss-Prot:P17622" /translation="MLIRYKKSFEKIAMGLLSFMPNEKDLKQLQQTIKDYETDTDRQL FLWKEDEDIVGAIGVEKKDSEVEIRHISVNPSHRHQGIGKQMMDALKHLFKTQVLVPN ELTQSFFERCQGQQDQDISYNN*" /label="ypzK CDS" gene complement(1961104..1961478) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /label="ypzK gene" downshifts complement(1961120) /Source="Nicolas_upshifts" /id="D1216" /incds=0 /nref=264 /ntot=275 /MaxReadThrough="1.34496" /MaxDrop="8.09525" /score="39.5464967" /energy="-14.3" /TU="NA" /idTUdmin="U1817" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1961540..1961559) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1961552) /Source="Nicolas_upshifts" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1961571..1961578) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1961591..1962055) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /EC_number="2.5.1.78" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3100522, 7473709, 10881048, 12456892, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3100522, 7473709, 10881048, 12456892, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6,7-dimethyl-8-ribityllumazine synthase, beta subunit" /protein_id="NP_390206.1" /db_xref="EnsemblGenomes-Gn:BSU23250" /db_xref="EnsemblGenomes-Tr:CAB14257" /db_xref="GOA:P11998" /db_xref="InterPro:IPR002180" /db_xref="InterPro:IPR034964" /db_xref="InterPro:IPR036467" /db_xref="PDB:1RVV" /db_xref="PDB:1ZIS" /db_xref="SubtiList:BG10521" /db_xref="UniProtKB/Swiss-Prot:P11998" /translation="MNIIQGNLVGTGLKIGIVVGRFNDFITSKLLSGAEDALLRHGVD TNDIDVAWVPGAFEIPFAAKKMAETKKYDAIITLGTVIRGATTHYDYVCNEAAKGIAQ AANTTGVPVIFGIVTTENIEQAIERAGTKAGNKGVDCAVSAIEMANLNRSFE*" /label="ribH CDS" gene complement(1961591..1962055) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /label="ribH gene" promotor_-35 1961926..1961930 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1961944..1961948 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1961947 /Source="Nicolas_upshifts" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1962088..1963284) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /EC_number="3.5.4.25" /EC_number="4.1.99.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9297088, 9515916, 12456892, 19583770, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9297088, 9515916, 12456892, 19583770, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II" /protein_id="NP_390207.1" /db_xref="EnsemblGenomes-Gn:BSU23260" /db_xref="EnsemblGenomes-Tr:CAB14258" /db_xref="GOA:P17620" /db_xref="InterPro:IPR000422" /db_xref="InterPro:IPR000926" /db_xref="InterPro:IPR016299" /db_xref="InterPro:IPR017945" /db_xref="InterPro:IPR032677" /db_xref="InterPro:IPR036144" /db_xref="SubtiList:BG10520" /db_xref="UniProtKB/Swiss-Prot:P17620" /translation="MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVI NFMATHGRGLICTPLSEEIADRLDLHPMVEHNTDSHHTAFTVSIDHRETKTGISAQER SFTVQALLDSKSVPSDFQRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVI CEIMNEDGTMARVPELIEIAKKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGT FKVYGYTNEVDGKEHVAFVMGDVPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAA LNQIAAEGRGVLLYLRQEGRGIGLINKLKAYKLQEQGYDTVEANEALGFLPDLRNYGI GAQILRDLGVRNMKLLTNNPRKIAGLEGYGLSISERVPLQMEAKEHNKKYLQTKMNKL GHLLHF*" /label="ribBA CDS" gene complement(1962088..1963284) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /label="ribBA gene" CDS complement(1963299..1963946) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /EC_number="2.5.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2106516, 12456892" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2106516, 12456892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="riboflavin synthase (alpha subunit)" /protein_id="NP_390208.1" /db_xref="EnsemblGenomes-Gn:BSU23270" /db_xref="EnsemblGenomes-Tr:CAB14259" /db_xref="GOA:P16440" /db_xref="InterPro:IPR001783" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR026017" /db_xref="SubtiList:BG10519" /db_xref="UniProtKB/Swiss-Prot:P16440" /translation="MFTGIIEETGTIESMKKAGHAMALTIKCSKILEDVHLGDSIAVN GICLTVTDFTKNQFTVDVMPETVKATSLNDLTKGSKVNLERAMAANGRFGGHFVSGHV DGTAEITRIEEKSNAVYYDLKMDPSLTKTLVLKGSITVDGVSLTIFGLTEDTVTISLI PHTISETIFSEKTIGSKVNIECDMIGKYMYRFLHKANENKTQQTITKAFLSENGF*" /label="ribE CDS" gene complement(1963299..1963946) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /label="ribE gene" CDS complement(1963957..1965042) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /EC_number="1.1.1.193" /EC_number="3.5.4.26" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9068650, 12456892, 17765262, 18986985, 23385458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068650, 12456892, 17765262, 18986985, 23385458; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino) uracil reductase" /protein_id="NP_390209.1" /db_xref="EnsemblGenomes-Gn:BSU23280" /db_xref="EnsemblGenomes-Tr:CAB14260" /db_xref="GOA:P17618" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR004794" /db_xref="InterPro:IPR011549" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024072" /db_xref="PDB:2B3Z" /db_xref="PDB:2D5N" /db_xref="PDB:3EX8" /db_xref="PDB:4G3M" /db_xref="SubtiList:BG10518" /db_xref="UniProtKB/Swiss-Prot:P17618" /translation="MEEYYMKLALDLAKQGEGQTESNPLVGAVVVKDGQIVGMGAHLK YGEAHAEVHAIHMAGAHAEGADIYVTLEPCSHYGKTPPCAELIINSGIKRVFVAMRDP NPLVAGRGISMMKEAGIEVREGILADQAERLNEKFLHFMRTGLPYVTLKAAASLDGKI ATSTGDSKWITSEAARQDAQQYRKTHQSILVGVGTVKADNPSLTCRLPNVTKQPVRVI LDTVLSIPEDAKVICDQIAPTWIFTTARADEEKKKRLSAFGVNIFTLETERIQIPDVL KILAEEGIMSVYVEGGSAVHGSFVKEGCFQEIIFYFAPKLIGGTHAPSLISGEGFQSM KDVPLLQFTDITQIGRDIKLTAKPTKE*" /label="ribD CDS" gene complement(1963957..1965042) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /label="ribD gene" S_feature complement(1965043..1965171) /Source="Nicolas_S_feature" /locus_tag="new_2431344_2431472_c" /HighExp="T0.30H, B60, T1.30H, T2.0H, MG-0.2, T1.0H, S1, T0.0H, LPhT, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S881" misc_RNA complement(1965172..1965316) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /product="flavin riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508, 17693491, 17997835" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508, 17693491, 17997835; Product type n: RNA" /label="fswA RNA" gene complement(1965172..1965316) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /label="fswA gene" promotor_-10 complement(1965333..1965352) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1965343) /Source="Nicolas_upshifts" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1965367..1965374) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1965436..1965780) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390211.1" /db_xref="EnsemblGenomes-Gn:BSU23300" /db_xref="EnsemblGenomes-Tr:CAB14262" /db_xref="SubtiList:BG10516" /db_xref="UniProtKB/Swiss-Prot:P17616" /translation="MGRIKTKITILLVLLLLLAGGYMYINDIELKDVPTAIGQTLSSE EEEYTIQEYKVTKIDGSEYHGVAENGTKIIFNGKKLNQDLSDIKEGDKIKAYFSKSKR IDGLIKVAKVND*" /label="ypuD CDS" gene complement(1965436..1965780) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /label="ypuD gene" downshifts complement(1965451) /Source="Nicolas_upshifts" /id="D1217" /incds=0 /nref=78 /ntot=221 /MaxReadThrough="1.58771" /MaxDrop="5.14851" /score="20.5522057" /energy="-14.7" /TU="NA" /idTUdmin="U1820" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1965812..1965830) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1965825) /Source="Nicolas_upshifts" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1965839..1965844 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1965845..1965851) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1965859..1966781 /Source="Nicolas_S_feature" /locus_tag="new_2432160_2433082" /HighExp="S5, S4, S6, S8, S7, C30, S3, C90, BT, BC" /AntisenseName="sipS" /AntisenseCor="-0.46666993867379197" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S882" upshifts 1965859 /Source="Nicolas_upshifts" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1965860..1965878 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1965866..1965881) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1965869) /Source="Nicolas_upshifts" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1965871..1965937) /Source="Nicolas_S_feature" /locus_tag="new_2432172_2432238_c" /HighExp="Etha, T1.30H, M9-stat, T0.30H, M40t90, T2.30H, MG-0.2, MG 15, HiTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S883" promotor_-35 complement(1965894..1965903) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1965932..1965940) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1965937) /Source="Nicolas_upshifts" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1965954..1965962) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1966015..1966569) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /EC_number="3.4.21.89" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390212.1" /db_xref="EnsemblGenomes-Gn:BSU23310" /db_xref="EnsemblGenomes-Tr:CAB14263" /db_xref="GOA:P28628" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG10515" /db_xref="UniProtKB/Swiss-Prot:P28628" /translation="MKSENVSKKKSILEWAKAIVIAVVLALLIRNFIFAPYVVDGDSM YPTLHNRERVFVNMTVKYIGEFDRGDIVVLNGDDVHYVKRIIGLPGDTVEMKNDQLYI NGKKVDEPYLAANKKRAKQDGFDHLTDDFGPVKVPDNKYFVMGDNRRNSMDSRNGLGL FTKKQIAGTSKFVFYPFNEMRKTN*" /label="sipS CDS" gene complement(1966015..1966569) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /label="sipS gene" downshifts complement(1966025) /Source="Nicolas_upshifts" /id="D1218" /incds=0 /nref=195 /ntot=252 /MaxReadThrough="3.6233" /MaxDrop="7.24702" /score="30.4586783" /energy="-10.9" /TU="U1824" /idTUdmin="U1825" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1966595..1966614) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1966613) /Source="Nicolas_upshifts" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1966615..1967014) /Source="Nicolas_S_feature" /locus_tag="new_2432916_2433315_c" /HighExp="T4.0H, T2.30H, T5.0H, T3.0H, T2.0H, T3.30H, M9-stat, C90, BC, T1.30H" /AntisenseName="ypzC" /AntisenseCor="-0.215992681600812" /AntisenseRegPval="-3.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S884" promotor_-35 complement(1966626..1966632) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1966836..1967072 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390213.1" /db_xref="EnsemblGenomes-Gn:BSU23320" /db_xref="EnsemblGenomes-Tr:CAB14264" /db_xref="SubtiList:BG13765" /db_xref="UniProtKB/Swiss-Prot:O32012" /translation="MFIYCIPLISQSMIPMALDKTINVMKVTGMFAATYFTGDNRTPF FAFIICLKSFKLENMDQPPKNKSNIFPAVEDSLL*" /label="ypzC CDS" gene 1966836..1967072 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /label="ypzC gene" CDS complement(1967015..1967221) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097757.1" /db_xref="EnsemblGenomes-Gn:BSU23328" /db_xref="EnsemblGenomes-Tr:CAX52656" /db_xref="InterPro:IPR018652" /db_xref="UniProtKB/Swiss-Prot:C0H447" /translation="MNNKGCIKCGSTEAGQKEIATTGTGLSKLFDVQHNRFLVVYCKN CGYSEFYNKESSTAGNILDLFFGG*" /label="ypzJ CDS" gene complement(1967015..1967221) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /label="ypzJ gene" misc_feature complement(1967254..1967273) /Source="Nicolas_upshift_promotors" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1967276) /Source="Nicolas_upshifts" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="upshifts" CDS complement(1967330..1967584) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="PSEUDO:CAX52657.1" /translation="MSFLVFVLIFLFVILTRRVCKLLHFFVYYRFIPHRAEPCVLYEQ YPSDVAAGYAFGGVWLSLNVLVMELFRFSRRFTKLRNEPN*" /label="ypuC CDS" gene complement(1967330..1967584) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /pseudo /label="ypuC gene" promotor_-35 1967464..1967473 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1967475..1967864) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15849754, 16850406" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="SubtiList:BG10514" /translation="MSYWIGYRLGPAAIQKAFASRGVLLAVIVLTFFWTVFRGQDRKI ELSFLFFLVIGGELYEEGIRRLFHSLHPVHAPLESHVLYPFPSEQTLTAFVIFGFCAY LFVRHSHKTRLQTVAFFCLLSFYSSSG*" /label="ypuC CDS" gene complement(1967475..1967864) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /pseudo /label="ypuC gene" S_feature 1967487..1968558 /Source="Nicolas_S_feature" /locus_tag="new_2433788_2434859" /HighExp="S6, S8, S7, BT, S5, B36, S4, Pyr, G/S, C30" /AntisenseName="ypuC" /AntisenseCor="0.37168085148262697" /AntisenseRegPval="-9.5" /CDS_PredictionProba="0.69113899999999995" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S885" promotor_-10 1967487..1967506 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1967487 /Source="Nicolas_upshifts" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1967842..1968045) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390215.1" /db_xref="EnsemblGenomes-Gn:BSU23340" /db_xref="EnsemblGenomes-Tr:CAB14266" /db_xref="SubtiList:BG10513" /db_xref="UniProtKB/Swiss-Prot:P35151" /translation="MQVLTGLLEQYGYAVLFIVLMLELLALLGPGEFAGVLVFQEKLN WVLSMLAAGLGSCGSEHVVLDRV*" /label="ypuB CDS" gene complement(1967842..1968045) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /label="ypuB gene" CDS 1968454..1968570 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90572.1" /translation="MYMHFESAQDDPITFARKAAAAFRVVKRIDRYLGFRKL*" /label="hypothetical protein CDS" gene 1968454..1968570 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /pseudo /label="gene" downshifts 1968521 /Source="Nicolas_upshifts" /id="D1219" /incds=0 /nref=3 /ntot=18 /MaxReadThrough="-0.179729999999999" /MaxDrop="3.76747" /score="-7.5033349" /energy="-9.1" /TU="NA" /idTUdmin="U1826" /TUdmin=198 /isTUend="FALSE" /label="downshifts" promotor_-35 1968647..1968656 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1968669..1968688 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1968669 /Source="Nicolas_upshifts" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1968711..1968923 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative germination protein" /protein_id="NP_390216.1" /db_xref="EnsemblGenomes-Gn:BSU23350" /db_xref="EnsemblGenomes-Tr:CAB14267" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13766" /db_xref="UniProtKB/Swiss-Prot:O32013" /translation="MIDYPININNVSGNSVINVGGAFMIRPLTLSKSVFGSGGLNTGI VFENNFVSKAKMINHQFTDQNVTKTF*" /label="ypzD CDS" gene 1968711..1968923 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /label="ypzD gene" downshifts 1968917 /Source="Nicolas_upshifts" /id="D1220" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="4.9048" /MaxDrop="3.6863" /score="3.56038753" /energy="-6.9" /TU="U1827" /idTUdmin="U1827" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" downshifts complement(1969059) /Source="Nicolas_upshifts" /id="D1221" /incds=0 /nref=254 /ntot=263 /MaxReadThrough="2.52018" /MaxDrop="8.47213" /score="34.3429406" /energy="-12.4" /TU="NA" /idTUdmin="U1828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1969059..1969490) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8639516, 9063446, 9748346, 25184565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8639516, 9063446, 9748346, 25184565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-prolyl isomerase" /protein_id="NP_390217.1" /db_xref="EnsemblGenomes-Gn:BSU23360" /db_xref="EnsemblGenomes-Tr:CAB14268" /db_xref="GOA:P35137" /db_xref="InterPro:IPR002130" /db_xref="InterPro:IPR020892" /db_xref="InterPro:IPR024936" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG10512" /db_xref="UniProtKB/Swiss-Prot:P35137" /translation="MKTGYFLLEDGNKIEFELYPEAAPGTVANFEKLANEGFYDGLTF HRVIPGFVSQGGCPHGTGTGGPGYTIKCETEGNPHTHEAGALSMAHAGKDTGGSQFFI VHEPQPHLNGVHTVFGKVTSGLEFAKNMSNGDVMKEVRVEG*" /label="ppiB CDS" gene complement(1969059..1969490) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /label="ppiB gene" S_feature complement(1969491..1969577) /Source="Nicolas_S_feature" /locus_tag="new_2435792_2435878_c" /HighExp="dia5, dia15, dia0, Lbexp, LBGtran, C90, Lbtran, HPh, G180, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S886" promotor_-10 complement(1969560..1969579) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1969577) /Source="Nicolas_upshifts" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1969593..1969598) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1969627..1969636 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1969646..1969743 /Source="Nicolas_S_feature" /locus_tag="new_2435947_2436044" /HighExp="Heat, Etha, Salt, dia0, HiTm, T0.30H, B60, Lbexp, T1.0H, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S887" upshifts 1969646 /Source="Nicolas_upshifts" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1969649..1969664 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1969744..1970616 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17434969, 18179421, 24706874; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390218.1" /db_xref="EnsemblGenomes-Gn:BSU23370" /db_xref="EnsemblGenomes-Tr:CAB14269" /db_xref="InterPro:IPR009343" /db_xref="SubtiList:BG10511" /db_xref="UniProtKB/Swiss-Prot:P31847" /translation="MKKIWIGMLAAAVLLLMVPKVSLADAAVGDVIVTLGADLSESDK QKVLDEMNVPDNATTVTVTNKEEHEYLGKYISNAQIGSRAISSSSITIAKKGSGLNVE THNISGITDEMYLNALMTAGVKDAKVYVTAPFEVSGTAALTGLIKAYEVSSDEAISED VKQVANQELVTTSELGDKIGNENAAALIAKIKEEFAKNGVPDNKADIEKQVDDAASDL NVTLTDSQKNQLVSLFNKMKNADIDWGQVSDQLDKAKDKITKFIESDEGKNFIQKVID FFVSIWNAIVSIFK*" /label="ypuA CDS" gene 1969744..1970616 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /label="ypuA gene" downshifts 1970523 /Source="Nicolas_upshifts" /id="D1222" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="5.9994" /MaxDrop="4.15288" /score="27.7277161" /energy="-12.7" /TU="U1829" /idTUdmin="U1829" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 1970589 /Source="Nicolas_upshifts" /id="D1223" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="1.98749" /MaxDrop="5.95835" /score="27.7277161" /energy="-12.7" /TU="NA" /idTUdmin="U1829" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1970646..1971965) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /EC_number="4.1.1.20" /experiment="publication(s) with functional evidences, PMID:9044297, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9044297, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-2,6-diaminopimelate decarboxylase" /protein_id="NP_390219.1" /db_xref="EnsemblGenomes-Gn:BSU23380" /db_xref="EnsemblGenomes-Tr:CAB14270" /db_xref="GOA:P23630" /db_xref="InterPro:IPR000183" /db_xref="InterPro:IPR002986" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR022643" /db_xref="InterPro:IPR022644" /db_xref="InterPro:IPR022653" /db_xref="InterPro:IPR022657" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10510" /db_xref="UniProtKB/Swiss-Prot:P23630" /translation="MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRER AKSFKQAFISAGLKAQVAYASKAFSSVAMIQLAEEEGLSLDVVSGGELYTAVAAGFPA ERIHFHGNNKSREELRMALEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGV EAHTHDYITTGQEDSKFGFDLHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGF VLAAEKIFKKLDEWRDSYSFVSKVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKEN ASRYGFDIPEIWIEPGRSLVGDAGTTLYTVGSQKEVPGVRQYVAVDGGMNDNIRPALY QAKYEAAAANRIGEAHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGY SMANNYNRIPRPAVVFVENGEAHLVVKRETYEDIVKLDLPFKTGVKQ*" /label="lysA CDS" gene complement(1970646..1971965) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /label="lysA gene" downshifts complement(1970666) /Source="Nicolas_upshifts" /id="D1224" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.99445" /MaxDrop="5.13504" /score="28.6775009" /energy="-12.7" /TU="NA" /idTUdmin="U1830" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1971966..1972030) /Source="Nicolas_S_feature" /locus_tag="new_2438267_2438331_c" /HighExp="C90, HiOs, BMM, GM 120, GM 25, MG-0.2, GM 15, GM-0.2, MG t5, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S888" promotor_-10 complement(1972026..1972045) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1972030) /Source="Nicolas_upshifts" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1972060..1972067) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1972071..1972689) /gene="spoVAF" /locus_tag="PG10_5'_ext_BSU_23390" /old_locus_tag="BSU_23390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AF" /protein_id="NP_390220.2" /db_xref="EnsemblGenomes-Gn:BSU23390" /db_xref="EnsemblGenomes-Tr:CAB14271" /db_xref="GOA:P31845" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10508" /db_xref="UniProtKB/Swiss-Prot:P31845" /modified_by="User" /translation="MTTSSGKIFRYSCFYFISSDLVSLCASA*SAPGQHEIYRFK*RY AYPDHPADIFS*LRNRVSQNGCHSHTDGFIDSNGFNCRCSDRADCD*GRPFFS*GDSV RLTCGDWNLYDA*L*IKLGKQNEPSCPHDTRCFISYKRARHRIYSANYCHGKHQIPSD TVLMAADSL*RKGAVAGSCPHSETWRKSKTQHRSPQKSLKAAYQFI" /label="PG10_5'_ext_BSU_23390" gene complement(1972071..1972689) /gene="PG10_5'_ext_BSU_23390" /locus_tag="PG10_pseudo_BSU_23390" /old_locus_tag="BSU_23390" /modified_by="User" /label="PG10_5'_ext_BSU_23390" SCAR join(1972675,1972682) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs23" N_region 1972676..1972681 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs23" S_feature complement(<1972682..1972698) /Source="Nicolas_S_feature" /locus_tag="new_2445036_2445093_c" /HighExp="S4, S3, S7, S5, S8, S6, T5.0H, BT, LoTm, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.859" /TUlongSig="NA" /TUlongPSig="NA" /label="S889" CDS complement(1972699..1973868) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /EC_number="3.4.16.4" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8021191, 8936302, 9864321, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021191, 8936302, 9864321, 19189487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicilin binding protein)" /protein_id="NP_390229.1" /db_xref="EnsemblGenomes-Gn:BSU23480" /db_xref="EnsemblGenomes-Tr:CAB14280" /db_xref="GOA:P38422" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10295" /db_xref="UniProtKB/Swiss-Prot:P38422" /translation="MKRLLSTLLIGIMLLTFAPSAFAKQDGKRTSELAHEAKSAVLIE RDTGKVLYNKNSNERLAPASMTKIMTMLLIMEALDKGKIKMSDKVRTSEHAASMGGSQ IFLEPGEEMTVKEMLKGIAIASGNDASVAMAEFISGSEEEFVKKMNKKAKELGLKNTS FKNPTGLTEEGHYSSAYDMAIMAKELLKYESITKFTGTYEDYLRENTDKKFWLVNTNR LIKFYPGVDGVKTGYTGEAKYCLTASAKKGNMRAIAVVFGASTPKERNAQVTKMLDFA FSQYETHPLYKRNQTVAKVKVKKGKQKFIELTTSEPISILTKKGEDMNDVKKEIKMKD NISAPIQKGQELGTLVLKKDGEVLAESPVAAKEDMKKAGFITFLKRTMGDWTKFK*" /label="dacF CDS" gene complement(1972699..1973868) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /label="dacF gene" promotor_-10 complement(1973897..1973908) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1973912) /Source="Nicolas_upshifts" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1973922..1973928) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1974014) /Source="Nicolas_upshifts" /id="D1226" /incds=0 /nref=243 /ntot=267 /MaxReadThrough="0.87114" /MaxDrop="7.5376" /score="26.8559416" /energy="-16.7" /TU="NA" /idTUdmin="U1836" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1974023..1974838) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 15530033, 21279421, 21543875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 15530033, 21279421, 21543875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_390230.1" /db_xref="EnsemblGenomes-Gn:BSU23490" /db_xref="EnsemblGenomes-Tr:CAB14281" /db_xref="GOA:P46354" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR011268" /db_xref="InterPro:IPR011270" /db_xref="InterPro:IPR018099" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG11330" /db_xref="UniProtKB/Swiss-Prot:P46354" /translation="MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLK YEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALG VEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDK DLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVA NHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYE*" /label="pupG CDS" gene complement(1974023..1974838) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /label="pupG gene" CDS complement(1974851..1976035) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /EC_number="5.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,5-phosphopentomutase" /protein_id="NP_390231.2" /db_xref="EnsemblGenomes-Gn:BSU23500" /db_xref="EnsemblGenomes-Tr:CAB14282" /db_xref="GOA:P46353" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR010045" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR024052" /db_xref="SubtiList:BG11331" /db_xref="UniProtKB/Swiss-Prot:P46353" /translation="MPAYKYNRVFLIVMDSVGIGEAPDAADFNDEGAHTLGHIAEHMN GLHMPNMAKLGLGLIEDIKGVEKTEHPLAYYGKMQEASNGKDTMTGHWEIMGLYIDKP FKVFPEGFPDELLQELEKRSGRKIIGNKPASGTAILDELGQEHMETGALIVYTSADSV LQIAAHEEVVPLEELYRICETARELTLDPKYMVGRIIARPFVGEPGQFKRTPNRHDYA LKPFDRTVMNELKDCGLDVISIGKISDIYDGEGITSSRRTVSNMDGMDKVIDTLGEDF TGLSFANLVDFDALFGHRRDPEGYGRALEEFDARLPEVFEKMREDDLLIITADHGNDP IHHGTDHTREYVPILAYSKKHKKAQMLPLADTFADIGATIADNFQTNKPKYGKSFLSL LQ*" /label="deoB CDS" gene complement(1974851..1976035) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /label="deoB gene" promotor_-10 complement(1976084..1976103) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1976102) /Source="Nicolas_upshifts" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1976104..1976195) /Source="Nicolas_S_feature" /locus_tag="new_2448499_2448590_c" /HighExp="S3, S4, M0t90, G180, S7, S8, Glucon, G135, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigEF, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S890" promotor_-35 complement(1976119..1976126) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1976196..1977086) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_390232.2" /db_xref="EnsemblGenomes-Gn:BSU23510" /db_xref="EnsemblGenomes-Tr:CAB14283" /db_xref="GOA:P46352" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011932" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG11332" /db_xref="UniProtKB/Swiss-Prot:P46352" /translation="MKDQIKDFIHYVMVERGLSQNTIVSYERDLKSYSLYLTETLHVT DWNHVTRIHIIQYLKHLKDSGKSGKTSARHLASIRSFHQFLLREKVTDKDPSVHIETQ KTERALPKVLALNEVERLLDTPKLTSPFGYRDKAMLELLYATGIRVSEMIELKTADVH LSMGFIRCFGKGRKERIVPIGEAAASAIEEYMTKARGKLLKNNVSDALFLNHHGKQIS RQGFWKNLKKIALEAGIKKELTPHTLRHSFATHLLENGADLRAVQEMLGHADISTTQI YTHVTKTRLKDVYKQFHPRA*" /label="ripX CDS" gene complement(1976196..1977086) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /label="ripX gene" CDS complement(1977094..1977321) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097760.1" /db_xref="EnsemblGenomes-Gn:BSU23519" /db_xref="EnsemblGenomes-Tr:CAX52660" /db_xref="GOA:C0H451" /db_xref="InterPro:IPR025321" /db_xref="UniProtKB/Swiss-Prot:C0H451" /translation="MGRFLKTAVDALKVFILFTGFTALFYYAMIWVNQEYENYHRYDK PEGSAVKVVEMDQDEKGGWFDRLIFFYQNGE*" /label="yqzK CDS" gene complement(1977094..1977321) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /label="yqzK gene" promotor_-10 complement(1977224..1977243) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1977235) /Source="Nicolas_upshifts" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1977257..1977264) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1977314) /Source="Nicolas_upshifts" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1977323..1977341) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1977351..1977369) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1977357..1977363) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1977364) /Source="Nicolas_upshifts" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1977386..1977391) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1977446) /Source="Nicolas_upshifts" /id="D1227" /incds=0 /nref=159 /ntot=251 /MaxReadThrough="4.06128" /MaxDrop="5.73495" /score="5.40881961" /energy="-8.1" /TU="U1840" /idTUdmin="U1841" /TUdmin=506 /isTUend="FALSE" /label="downshifts" CDS complement(1977446..1977895) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for iron transport andmetabolism" /protein_id="NP_390233.2" /db_xref="EnsemblGenomes-Gn:BSU23520" /db_xref="EnsemblGenomes-Tr:CAB14284" /db_xref="GOA:P54574" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11766" /db_xref="UniProtKB/Swiss-Prot:P54574" /translation="MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVY LLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDGVSRYDLRKEGAAHFHHHLVCME CGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE*" /label="fur CDS" gene complement(1977446..1977895) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /label="fur gene" promotor_-10 complement(1977919..1977938) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-10" upshifts complement(1977929) /Source="Nicolas_upshifts" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="upshifts" S_feature complement(1977931..1978007) /Source="Nicolas_S_feature" /locus_tag="new_2450326_2450402_c" /HighExp="S3, S4, S5, BT, LoTm, M9-stat, T5.0H, T3.30H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S891" promotor_-35 complement(1977954..1977958) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-35" CDS complement(1978008..1978652) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17376078, 17824930, 20382772, 23859254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17376078, 17824930, 20382772, 23859254; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="autolysin component for dissolution of the septal cell wall (stage II sporulation)" /protein_id="NP_390234.1" /db_xref="EnsemblGenomes-Gn:BSU23530" /db_xref="EnsemblGenomes-Tr:CAB14285" /db_xref="GOA:P37873" /db_xref="InterPro:IPR002798" /db_xref="InterPro:IPR014196" /db_xref="SubtiList:BG10768" /db_xref="UniProtKB/Swiss-Prot:P37873" /translation="MRKISYKDMFLRHVKDHLSLYIFVSVLFFMGVIFGAIIVNSMTI SQKEDLYYYLSQFFGQLSDGKQASSADMFGQSIFHNAKYLGLMWILGISVIGMPIIFI MIFLKGIVVGFTVGFLVNQMGVSGFFLSFVSVLPQNVLLIPAYLIMGTCAIAFSLKLI RQLFVKRSLHDAPIQWFGRYAFVLLVILFLALISSLFEAYLSPVLMEKLTSRLF*" /label="spoIIM CDS" gene complement(1978008..1978652) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /label="spoIIM gene" promotor_-10 complement(1978683..1978701) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-10" upshifts complement(1978700) /Source="Nicolas_upshifts" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="upshifts" promotor_-35 complement(1978716..1978721) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-35" CDS complement(1978753..1978968) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390235.1" /db_xref="EnsemblGenomes-Gn:BSU23540" /db_xref="EnsemblGenomes-Tr:CAB14286" /db_xref="SubtiList:BG11765" /db_xref="UniProtKB/Swiss-Prot:P54573" /translation="MAKSQAKKKRGHRLRNGGRDVLLSRGSTPSFSTHGRMTKSKKEI LNKRKHKNPYDHTAVDDKDFFVPQKAA*" /label="yqkK CDS" gene complement(1978753..1978968) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /label="yqkK gene" downshifts complement(1978833) /Source="Nicolas_upshifts" /id="D1228" /incds=1 /nref=17 /ntot=130 /MaxReadThrough="0.857610000000001" /MaxDrop="3.7055" /score="1.77181315" /energy="-9.8" /TU="NA" /idTUdmin="U1842" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1979068..1980387) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 23136871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catabolic NAD-dependent malic enzyme (conversionof malate into pyruvate)" /protein_id="NP_390236.1" /db_xref="EnsemblGenomes-Gn:BSU23550" /db_xref="EnsemblGenomes-Tr:CAB14287" /db_xref="GOA:P54572" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11764" /db_xref="UniProtKB/Swiss-Prot:P54572" /translation="MIAKHMIRTLMIETPSVPGNLGRVATAIGLLGGDIGEVETVKVG PNYTMRNITVQVENEEQLQEVIAAVQALGEGIRLHTVSDEVLSAHEGGKIQMKSKMPI RSLAELGRVYTPGVADVCRLIEKEPEKASIYTTISNSVAIVTDGTAILGLGNIGSVAG MPVMEGKAALFDQLAGISGIPILLDTSDPEEIIKTVKHISPGFSGILLEDIGSPHCFE IEDRLKEELNIPVMHDDQHGTAVVTLAAAISACRSAGVDLKEAKVGQIGLGAAGVAIC RMFMAYGVNAVYGTDKSESAMNRLEQYGGQAVSSIEELMETCDIVIATTGVPGLIKPA FVRSGQVILALSNPKPEIEPEAALQAGAAYAADGRSVNNVLGFPGIFRGALNAKSTEI NHDMLVAAAEAIAACTKQGDVVPQPLDSKVHHAVAAAVEHAALTAVK*" /label="mleA CDS" gene complement(1979068..1980387) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /label="mleA gene" downshifts complement(1979075) /Source="Nicolas_upshifts" /id="D1229" /incds=0 /nref=29 /ntot=84 /MaxReadThrough="3.50516" /MaxDrop="5.65279" /score="42.1653011" /energy="-15.2" /TU="U1842,U1843" /idTUdmin="U1842" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" CDS complement(1980405..1981811) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10903309, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10903309, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="malate-H+/Na+-lactate antiporter" /protein_id="NP_390237.1" /db_xref="EnsemblGenomes-Gn:BSU23560" /db_xref="EnsemblGenomes-Tr:CAB14288" /db_xref="GOA:P54571" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG11763" /db_xref="UniProtKB/Swiss-Prot:P54571" /translation="MKDVRLPTLFEIIIVLGVFLALVLSFTVFLDLPIQLALFVSWFI AMLLGIRLGYSYKDLQNAIVHGISNGLEAVLILVSVGALIGTWIAGGVVPTLIYYGLE FIHPSIFLLATLIICSIMSVATGTSWGTVGTAGIAMIAIGEGLGIPLPLVAGAILSGA YFGDKLSPLSDSTVLASSLSKVDVLAHVRAMLYLSIPAYVITAILFTVVGFMYGGKNI DLDKVEFLKSSLQNTFDIHIWMLIPAVLVIVLLAMKKPSMPVIVIGALLGAIWAVVFQ GMDIAHAIATAYNGFSIKTDVEFLNGLLNRGGIVGMLDSLVVIIFGLGFGGLLEKLGV LKVIVSTFEKKLTSAGNVTLSTLIVAFLANIFGCAMYVSLILTPKIMEDSYDRLHLDR RVLSRNSEVGGTLTSGMVPWSDNGIYMAGILGVSTFSYLPFMWLSFVAIGLAIIYGYT GKFIWYTKNNTVKAEKLG*" /label="mleN CDS" gene complement(1980405..1981811) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /label="mleN gene" promotor_-10 complement(1981859..1981878) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1981868) /Source="Nicolas_upshifts" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1981870..1981951) /Source="Nicolas_S_feature" /locus_tag="new_2454265_2454346_c" /HighExp="S0, dia0, dia5, Lbexp, G150, Oxctl, G135, Mt0, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S892" promotor_-35 complement(1981893..1981900) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1981952..1983379) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /EC_number="4.3.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-aspartase (aspartate ammonia lyase)" /protein_id="NP_390238.2" /db_xref="EnsemblGenomes-Gn:BSU23570" /db_xref="EnsemblGenomes-Tr:CAB14289" /db_xref="GOA:P26899" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004708" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10301" /db_xref="UniProtKB/Swiss-Prot:P26899" /translation="MLNGQKEYRVEKDFLGEKQIEADVYYGIQTLRASENFPITGYKI HEEMINALAIVKKAAALANMDVKRLYEGIGQAIVQAADEILEGKWHDQFIVDPIQGGA GTSMNMNANEVIGNRALEIMGHKKGDYIHLSPNTHVNMSQSTNDVFPTAIHISTLKLL EKLLKTMEDMHSVFKQKAQEFDSVIKMGRTHLQDAVPIRLGQEFEAYSRVLERDIKRI KQSRQHLYEVNMGATAVGTGLNADPEYIKQVVKHLADISGLPLVGADHLVDATQNTDA YTEVSASLKVCMMNMSKIANDLRLMASGPRAGLAEISLPARQPGSSIMPGKVNPVMAE LINQIAFQVIGNDNTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRSFTDNCLK GIEANEKRMKQYVEKSAGVITAVNPHLGYEAAARIAREAIMTGQSVRDLCLQHDVLTE EELDIILNPYEMTKPGIAGKELLEK*" /label="ansB CDS" gene complement(1981952..1983379) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /label="ansB gene" CDS complement(1983424..1984413) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /EC_number="3.5.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029, 11914346, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029, 11914346, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported L-asparaginase" /protein_id="NP_390239.1" /db_xref="EnsemblGenomes-Gn:BSU23580" /db_xref="EnsemblGenomes-Tr:CAB14290" /db_xref="GOA:P26900" /db_xref="InterPro:IPR006033" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG10300" /db_xref="UniProtKB/Swiss-Prot:P26900" /translation="MKKLLMLTTGGTIASVEGENGLAPGVKADELLSYVSKLDNDYTM ETQSLMNIDSTNMQPEYWVEIAEAVKENYDAYDGFVITHGTDTMAYTSAALSYMLQHA KKPIVITGSQIPITFQKTDAKKNITDAIRFACEGVGGVYVVFDGRVIQGTRAIKLRTK SYDAFESINYPYIAFINEDGIEYNKQVTEPENDTFTVDTSLCTDVCLLKLHPGLKPEM FDALKSMYKGIVIESYGSGGVPFEGRDILSKVNELIESGIVVVITTQCLEEGEDMSIY EVGRRVNQDLIIRSRNMNTEAIVPKLMWALGQSSDLPVVKRIMETPIADDVVL*" /label="ansA CDS" gene complement(1983424..1984413) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /label="ansA gene" S_feature complement(1984414..1984493) /Source="Nicolas_S_feature" /locus_tag="new_2456809_2456888_c" /HighExp="dia0, Lbexp, G150, Oxctl, dia5, LBGexp, Paraq, C30, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S893" promotor_-10 complement(1984475..1984494) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1984493) /Source="Nicolas_upshifts" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1984495..1984815) /Source="Nicolas_S_feature" /locus_tag="new_2456890_2457210_c" /HighExp="LBGstat, S5, G135, S8, S6, LBGtran, G180, G150, LoTm, LBGexp" /AntisenseName="ansR" /AntisenseCor="0.23077291929287899" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S894" promotor_-35 complement(1984509..1984516) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1984534..1984541 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1984554..1984573 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1984556 /Source="Nicolas_upshifts" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="upshifts" CDS 1984595..1984945 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of ansAB (Xre family)" /protein_id="NP_390240.1" /db_xref="EnsemblGenomes-Gn:BSU23590" /db_xref="EnsemblGenomes-Tr:CAB14291" /db_xref="GOA:Q07683" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG10299" /db_xref="UniProtKB/Swiss-Prot:Q07683" /translation="MNLDRLTELRKKKNWSLQYTADLLGIAKSTYAGYESGYRRPSLE ALAMLADLFDTTCDELLGREKQKQTAPQAIELATWSSLDFTISVDGQPLSEDEIIQLI TFIRTKRKVQEELS*" /label="ansR CDS" gene 1984595..1984945 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /label="ansR gene" S_feature complement(1984817..1984953) /Source="Nicolas_S_feature" /locus_tag="new_2457212_2457348_c" /HighExp="LBGstat, S8, S6, S7, S5, ferm, nit, LBGtran, BT, LPhT" /AntisenseName="ansR" /AntisenseCor="-0.22421651781702501" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S895" downshifts complement(1984860) /Source="Nicolas_upshifts" /id="D1230" /incds=1 /nref=4 /ntot=116 /MaxReadThrough="3.90926" /MaxDrop="4.76642" /score="10.2434094" /energy="-23.6" /TU="U1847" /idTUdmin="U1845" /TUdmin=1451 /isTUend="FALSE" /label="downshifts" CDS complement(1984954..1986117) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleotide binding protein" /protein_id="NP_390241.2" /db_xref="EnsemblGenomes-Gn:BSU23600" /db_xref="EnsemblGenomes-Tr:CAB14292" /db_xref="GOA:P38423" /db_xref="InterPro:IPR005287" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG11073" /db_xref="UniProtKB/Swiss-Prot:P38423" /translation="MKKIYADLHIHIGRTFTGRAVKITGAKTLTLDRILVEASEHKGI ELLGIIDCHSPEVILELEEGISSGKYRELDGGGIRYRSTTLLLGSELEIYDEACSGPI HVLVFMPTLADMKQFSNWLSARLKNIHLSSQRIYETGLNLQKKVQDMGGLFIPAHIFT PHKSLYGKGVKSSLTEVFDPSMIDAVELGLSCDTDMASHVSQLNPYPFLTNSDAHSLG KIGREYNELYVQSADFTEFALALKGQDDRKIIANYGLDPLLGKYYQTACEACGEPAVS GETACANCGKARFTKGVSDRLRELSDQLEVRVPRPRYVHQIPLQFVPGVGPKTLDKLK KAFGTEMAVLHEAAEEDLARVVPPKTAALIVKARSGKLELKAGGGGTYGKIKP*" /label="yqxK CDS" gene complement(1984954..1986117) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /label="yqxK gene" CDS complement(1986114..1986671) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /EC_number="3.1.7.1" /EC_number="3.6.1.13" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10542272, 17693564, 21638333, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl pyrophosphate and dimethylallyl pyrophosphate diphosphatase (moonlighting ADP-ribose pyrophosphatase)" /protein_id="NP_390242.1" /db_xref="EnsemblGenomes-Gn:BSU23610" /db_xref="EnsemblGenomes-Tr:CAB14293" /db_xref="GOA:P54570" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11762" /db_xref="UniProtKB/Swiss-Prot:P54570" /translation="MKSLEEKTIAKEQIFSGKVIDLYVEDVELPNGKASKREIVKHPG AVAVLAVTDEGKIIMVKQFRKPLERTIVEIPAGKLEKGEEPEYTALRELEEETGYTAK KLTKITAFYTSPGFADEIVHVFLAEELSVLEEKRELDEDEFVEVMEVTLEDALKLVES REVYDAKTAYAIQYLQLKEALQAQK*" /label="nudF CDS" gene complement(1986114..1986671) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /label="nudF gene" promotor_no_box complement(1986601..1986701) /Source="Nicolas_upshift_promotors" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1986641) /Source="Nicolas_upshifts" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1986685..1986690 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1986706..1986724 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1986708..1986722) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-10" upshifts 1986712 /Source="Nicolas_upshifts" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="upshifts" S_feature 1986719..1986893 /Source="Nicolas_S_feature" /locus_tag="new_2459114_2459288" /HighExp="S4, S5, S3, S7, S6, LoTm, BT, T5.0H, G/S, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99962399999999996" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S896" promotor_-35 complement(1986724..1986727) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-35" upshifts complement(1986727) /Source="Nicolas_upshifts" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="upshifts" CDS 1986746..1986868 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /function="15.1: Cell division" /experiment="publication(s) with functional evidences, PMID:18284588, 23237472, 25848052, 27752253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18284588, 23237472, 25848052, 27752253; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="YP_009513976.1" /db_xref="EnsemblGenomes-Gn:BSU23616" /db_xref="EnsemblGenomes-Tr:CCQ48600" /db_xref="GOA:L8EBJ9" /db_xref="InterPro:IPR025177" /db_xref="PDB:2MRW" /db_xref="PDB:4U39" /db_xref="UniProtKB/TrEMBL:L8EBJ9" /translation="MKVHRMPKGVVLVGKAWEIRAKLKEYGRTFQYVKDWISKP*" /label="mciZ CDS" gene 1986746..1986868 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /label="mciZ gene" promotor_-35 1986869..1986876 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1986890..1986909 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1986895 /Source="Nicolas_upshifts" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="upshifts" CDS 1986931..1987851 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /EC_number="1.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9643546, 15317791, 16242712, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent aldo-keto reductase (acts on 4-hydroxy-2,3-trans-nonenal)" /protein_id="NP_390243.1" /db_xref="EnsemblGenomes-Gn:BSU23620" /db_xref="EnsemblGenomes-Tr:CAB14294" /db_xref="GOA:P54569" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11761" /db_xref="UniProtKB/Swiss-Prot:P54569" /translation="MRKRKLGTSDLDISEVGLGCMSLGTEKNKALSILDEAIELGINY LDTADLYDRGRNEEIVGDAIQNRRHDIILATKAGNRWDDGSEGWYWDPSKAYIKEAVK KSLTRLKTDYIDLYQLHGGTIEDNIDETIEAFEELKQEGVIRYYGISSIRPNVIKEYV KKSNIVSIMMQFSLFDRRPEEWLPLLEEHQISVVARGPVAKGLLTEKPLDQASESMKQ NGYLSYSFEELTNARKAMEEVAPDLSMTEKSLQYLLAQPAVASVITGASKIEQLRENI QAANARRLTEEEIKALQSHTKQDIYKAHRS*" /label="yqkF CDS" gene 1986931..1987851 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /label="yqkF gene" downshifts 1987840 /Source="Nicolas_upshifts" /id="D1231" /incds=0 /nref=186 /ntot=248 /MaxReadThrough="1.49159" /MaxDrop="5.81013" /score="18.6018806" /energy="-14.8" /TU="NA" /idTUdmin="U1846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1987883..1988107) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390244.1" /db_xref="EnsemblGenomes-Gn:BSU23630" /db_xref="EnsemblGenomes-Tr:CAB14295" /db_xref="InterPro:IPR024980" /db_xref="SubtiList:BG11760" /db_xref="UniProtKB/Swiss-Prot:P54568" /translation="MKKQKSIDKHQLKDGLQSDIKAKLMEMKSQLKEEDEKRQKREKA EQIRKKKEIEKNKSFEELLNESQMDWHQYK*" /label="yqkE CDS" gene complement(1987883..1988107) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /label="yqkE gene" downshifts complement(1987940) /Source="Nicolas_upshifts" /id="D1232" /incds=0 /nref=19 /ntot=195 /MaxReadThrough="0.59953" /MaxDrop="5.9087" /score="15.8160537" /energy="-13" /TU="NA" /idTUdmin="U1849" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1988130..1988149) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1988137) /Source="Nicolas_upshifts" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1988164..1988171) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1988186..1988193 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1988208..1988227 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1988215 /Source="Nicolas_upshifts" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="upshifts" CDS 1988269..1989186 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390245.1" /db_xref="EnsemblGenomes-Gn:BSU23640" /db_xref="EnsemblGenomes-Tr:CAB14296" /db_xref="GOA:P54567" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11759" /db_xref="UniProtKB/Swiss-Prot:P54567" /translation="MKKILLAIGALVTAVIAIGIVFSHMILFIKKKTDEDIIKRETDN GHDVFESFEQMEKTAFVIPSAYGYDIKGYHVAPHDTPNTIIICHGVTMNVLNSLKYMH LFLDLGWNVLIYDHRRHGQSGGKTTSYGFYEKDDLNKVVSLLKNKTNHRGLIGIHGES MGAVTALLYAGAHCSDGADFYIADCPFACFDEQLAYRLRAEYRLPSWPLLPIADFFLK LRGGYRAREVSPLAVIDKIEKPVLFIHSKDDDYIPVSSTERLYEKKRGPKALYIAENG EHAMSYTKNRHTYRKTVQEFLDNMNDSTE*" /label="yqkD CDS" gene 1988269..1989186 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /label="yqkD gene" downshifts 1989161 /Source="Nicolas_upshifts" /id="D1233" /incds=0 /nref=27 /ntot=171 /MaxReadThrough="2.02201" /MaxDrop="3.99393" /score="14.106821" /energy="-11.8" /TU="NA" /idTUdmin="U1850" /TUdmin=594 /isTUend="FALSE" /label="downshifts" CDS complement(1989226..1989465) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390246.1" /db_xref="EnsemblGenomes-Gn:BSU23650" /db_xref="EnsemblGenomes-Tr:CAB14297" /db_xref="InterPro:IPR020157" /db_xref="SubtiList:BG11758" /db_xref="UniProtKB/Swiss-Prot:P54566" /translation="MEQKLKAMKNTAQNKTWVSFLNQNHPYTLLHWSIGGAESIKKDV WLLQDEMTFETQEFTTIDLAIEWIRENMDGITDVL*" /label="yqkC CDS" gene complement(1989226..1989465) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /label="yqkC gene" downshifts complement(1989237) /Source="Nicolas_upshifts" /id="D1234" /incds=0 /nref=215 /ntot=269 /MaxReadThrough="3.31829" /MaxDrop="6.35785" /score="16.3526162" /energy="-11.2" /TU="NA" /idTUdmin="U1851" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1989478..1989801) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390247.1" /db_xref="EnsemblGenomes-Gn:BSU23660" /db_xref="EnsemblGenomes-Tr:CAB14298" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11757" /db_xref="UniProtKB/Swiss-Prot:P54565" /translation="MNIHVTDAAKQALQQAFDANPGKKAQLRYDAEGCGCAVSGVPTI WLAEELTGQCEQLETNGIPLYIQSSQKVFFDDQMTIDYNEKAKTLALKSPAEMLSPRM SILVK*" /label="yqkB CDS" gene complement(1989478..1989801) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /label="yqkB gene" promotor_-10 complement(1989544..1989563) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1989545) /Source="Nicolas_upshifts" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1989577..1989584) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1989798..1990829) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390248.1" /db_xref="EnsemblGenomes-Gn:BSU23670" /db_xref="EnsemblGenomes-Tr:CAB14299" /db_xref="GOA:P54564" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR007344" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11756" /db_xref="UniProtKB/Swiss-Prot:P54564" /translation="MIEFLQHKEATIAREILAVQIPAYIKETEIIGFDGIPALQEKVK DIQASHERFAGYRKNGKLIGVISYEKNMHYLTICRLVVHPDGFRKGIGRALLQFVIDH NEDAEKIEVVTAENNTPAVSLYTQAGFQKAETVKAAQGLLLSVFHLYPKRKVEIILYN EKWAECFDEEKERLKLVFGPEIIAIHHIGSTSIPNMAAKPIIDMLIEVRSIEAVSQFD EQMKANGYTPKGENGIAGRRYFQKGGNKRTHHVHMYEQGNPAIERHLLFRDYLRAHPN IAKEYAVLKKQLAAQHPDSINQYIQGKDEWIKTAEENAKRWKKGRNNANGSIVCYNSE NDENGGFTL*" /label="yqkA CDS" gene complement(1989798..1990829) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /label="yqkA gene" promotor_-10 complement(1989825..1989844) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1989832) /Source="Nicolas_upshifts" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1989855..1989862) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1990822..1991166) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradation enzyme (oxygenase)" /protein_id="NP_390249.1" /db_xref="EnsemblGenomes-Gn:BSU23680" /db_xref="EnsemblGenomes-Tr:CAB14300" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:2GO8" /db_xref="SubtiList:BG11755" /db_xref="UniProtKB/Swiss-Prot:P54563" /translation="MMDFLSKTPEPPYYAVIFSSVKSENDTGYGETAERMVSLAADQP GFLGVESVREADGRGITVSYWDSMDAINHWRHHTEHQAAKEKGRSVWYESYAVRVAKV DRQRLFQENTND*" /label="yqjZ CDS" gene complement(1990822..1991166) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /label="yqjZ gene" CDS complement(1991176..1991646) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390250.1" /db_xref="EnsemblGenomes-Gn:BSU23690" /db_xref="EnsemblGenomes-Tr:CAB14301" /db_xref="GOA:P54562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017255" /db_xref="PDB:1MK4" /db_xref="SubtiList:BG11754" /db_xref="UniProtKB/Swiss-Prot:P54562" /translation="MDIRTITSSDYEMVTSVLNEWWGGRQLKEKLPRLFFEHFQDTSF ITSEHNSMTGFLIGFQSQSDPETAYIHFSGVHPDFRKMQIGKQLYDVFIETVKQRGCT RVKCVTSPVNKVSIAYHTKLGFDIEKGTKTVNGISVFANYDGPGQDRVLFVKNI*" /label="yqjY CDS" gene complement(1991176..1991646) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /label="yqjY gene" S_feature complement(1991647..1991723) /Source="Nicolas_S_feature" /locus_tag="new_2464042_2464118_c" /HighExp="SMM, T-4.40H, MG 150, M9-tran, GM 90, T-3.40H, GM-0.2, M9-exp, GM 120, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigEF" /TUlongPSig="0.776" /label="S897" downshifts 1991647 /Source="Nicolas_upshifts" /id="D1235" /incds=0 /nref=8 /ntot=121 /MaxReadThrough="0.87367" /MaxDrop="3.61005" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1991698..1991717) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1991723) /Source="Nicolas_upshifts" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1991725..1991831) /Source="Nicolas_S_feature" /locus_tag="new_2464120_2464226_c" /HighExp="M40t90, S4, M40t45, S6, H2O2, S5, S3, S8, S7, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.776" /TUlongSig="NA" /TUlongPSig="NA" /label="S898" promotor_-35 complement(1991732..1991739) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1991832..1992170) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390251.1" /db_xref="EnsemblGenomes-Gn:BSU23700" /db_xref="EnsemblGenomes-Tr:CAB14302" /db_xref="GOA:P54561" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG11753" /db_xref="UniProtKB/Swiss-Prot:P54561" /translation="MNDHLKRGNLLWEGSRMFLPEHKQSLLERKRLKQKLQKPILDPD KLEEMNQTLCAAMEFAQDITVSCFQDGEIVCCTGKICRYEEFEKAVWIKGDEDQLYKL KLDQVLDIVL*" /label="yqjX CDS" gene complement(1991832..1992170) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /label="yqjX gene" CDS complement(1992167..1993405) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /EC_number="2.7.7.7" /function="16.5: Explore" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Y family DNA polymerase V bypassing lesions during replication" /protein_id="NP_390252.1" /db_xref="EnsemblGenomes-Gn:BSU23710" /db_xref="EnsemblGenomes-Tr:CAB14303" /db_xref="GOA:P54560" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11752" /db_xref="UniProtKB/Swiss-Prot:P54560" /translation="MMKEKVIFLVDMQSFYASVEKAENPHLKNRPVIVSGDPEKRGGV VLAACPLAKQKGVVNASRLWEAQEKCPEAVVLRPRMQRYIDVSLQITAILEEYTDLVE PYSIDEQFMDITGSQKLFGTPMEIAKSIQGRIMREIGVYARVGIGPNKALAKIACDNF AKKNKNGIFTLTKENMKTEMWPLPVGSMFGVGSRMKHHLNRMGISTIGGLAAFPLDLL KKKWGINGHVLWMTANGIDYSPVSTSSLDGQKAIGHGMTLPRDYEHFDKEIKVVLLEL SEEVCRRSRNAGVMGQTVSVSCRGADFDWPTGFNRQVKLAEPTNSTQDVYEAVRRLFL TFWDGKPVRRLGVNLSQLSSDDIWQLNLFQDYAKKMSLGYVMDGIKNRFGDTAIIRAA SLTAAGQAFERAAKIGGHYK*" /label="polYB CDS" gene complement(1992167..1993405) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /label="polYB gene" misc_feature 1992329..1992330 /Source="Nicolas_upshift_promotors" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1992340 /Source="Nicolas_upshifts" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1992395 /Source="Nicolas_upshifts" /id="D1236" /incds=1 /nref=2 /ntot=2 /MaxReadThrough="-0.14995" /MaxDrop="4.86715" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1993430..1993448) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-10" upshifts complement(1993439) /Source="Nicolas_upshifts" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="upshifts" promotor_-35 complement(1993465..1993470) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-35" promotor_-35 1993510..1993513 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1993528..1993547 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1993537 /Source="Nicolas_upshifts" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="upshifts" CDS 1993571..1993777 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390253.1" /db_xref="EnsemblGenomes-Gn:BSU23720" /db_xref="EnsemblGenomes-Tr:CAB14304" /db_xref="InterPro:IPR025546" /db_xref="SubtiList:BG13774" /db_xref="UniProtKB/Swiss-Prot:O32014" /translation="MEKFVEKMLGQALRQYGRNVAIDPLSPYEKQSLKAALQERRNEE PDEDLHAHIEDIIYDYVTNQGLFS*" /label="yqzH CDS" gene 1993571..1993777 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /label="yqzH gene" promotor_-35 1994260..1994263 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1994278..1994297 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1994294 /Source="Nicolas_upshifts" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="upshifts" CDS 1994326..1995558 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390254.2" /db_xref="EnsemblGenomes-Gn:BSU23730" /db_xref="EnsemblGenomes-Tr:CAB14305" /db_xref="GOA:P54559" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11751" /db_xref="UniProtKB/Swiss-Prot:P54559" /translation="MKKWKDIHPISWTIIIGTIFGRMATSMSIPFLAIYLTAVQGASA SYAGLVIAASSSVGILASFYGGYISDKFGRKNMMLVSIFGWMLVFAGFAAASNLWVFF VVNALNGLCKSLFEPASKALLSDMTEEKTRLLVFNLRYAAINIGVVFGPVLGLYFGSS QSTTPFLVPAVIYGLYGIVLALQFKKHPSLSAPAQSRNMSVREAFMVTQKDYLFTIAL VGITLCTFGYSQFSSTFPQYMAQNPLIGNGTKLYGLMLTLNAIVVLATQFPIVHFAKR FSPLCSLMLGNVMVSISMAIFTVSHGVPSIVMIVITFTIGEVLLFSMMDLYVDQIAKP GLKGTYFGAIGFSQLGNVIGPWVGGICIDLFGAGRPIYIFSVLSGITLLGLPFLAFAY RQMKMETTKHRSRLEKPL*" /label="yqjV CDS" gene 1994326..1995558 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /label="yqjV gene" CDS 1995405..1995767 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390255.2" /db_xref="EnsemblGenomes-Gn:BSU23740" /db_xref="EnsemblGenomes-Tr:CAB14306" /db_xref="GOA:P54558" /db_xref="SubtiList:BG11750" /db_xref="UniProtKB/Swiss-Prot:P54558" /translation="MYRPVWRWPADLYFFCPERHYPARPAIFSVRLSANENGDHKTPF PSGKAALNKKRKRMNLSRKHEVKNMNIGDVMFQLFVFIIFAAVVFAAVTGFKYAKNRK AQLDRIEKKLNSLSEDHD*" /label="yqjU CDS" gene 1995405..1995767 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /label="yqjU gene" S_feature complement(1995584..1995763) /Source="Nicolas_S_feature" /locus_tag="new_2467979_2468158_c" /HighExp="Sw, BC, C90, C30, M0t90, BI, Lbtran, Lbstat, M40t45, G135" /AntisenseName="yqjU" /AntisenseCor="-0.38632421151235602" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S899" downshifts complement(1995617) /Source="Nicolas_upshifts" /id="D1237" /incds=0 /nref=59 /ntot=226 /MaxReadThrough="1.66997" /MaxDrop="4.81479" /score="21.7095422" /energy="-11.4" /TU="NA" /idTUdmin="U1858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1995764..1996150) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390256.1" /db_xref="EnsemblGenomes-Gn:BSU23750" /db_xref="EnsemblGenomes-Tr:CAB14307" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11749" /db_xref="UniProtKB/Swiss-Prot:P54557" /translation="MHHIELYVSDLEASRRFWGWFLKELGYKEYQKWSSGISWKKDRF YLVIVQAKEPFLEPEYHRCRVGLNHLAFHAESKLQVDQMTEKLTAKGYRVLYRDRHPF AGGDGHYAVFCEDPDRIKVELVAPSC*" /label="yqjT CDS" gene complement(1995764..1996150) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /label="yqjT gene" CDS complement(1996154..1997113) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328157, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328157, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase" /protein_id="NP_390257.2" /db_xref="EnsemblGenomes-Gn:BSU23760" /db_xref="EnsemblGenomes-Tr:CAB14308" /db_xref="GOA:P54556" /db_xref="InterPro:IPR004566" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11748" /db_xref="UniProtKB/Swiss-Prot:P54556" /translation="MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLND YLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGK STTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEF LNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPR IFVSDFFDFSIYVDAEESRIFTWYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMA ASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV*" /label="coaA CDS" gene complement(1996154..1997113) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /label="coaA gene" S_feature complement(1997114..1997184) /Source="Nicolas_S_feature" /locus_tag="new_2469509_2469579_c" /HighExp="LBGtran, dia15, Diami, C90, H2O2, M0t45, G135, Lbtran, HiTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S900" CDS complement(1997185..1998531) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /EC_number="4.3.1.18" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-serine ammonia-lyase" /protein_id="NP_390258.2" /db_xref="EnsemblGenomes-Gn:BSU23770" /db_xref="EnsemblGenomes-Tr:CAB14309" /db_xref="GOA:P54555" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011780" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG11747" /db_xref="UniProtKB/Swiss-Prot:P54555" /translation="MSVHSEVLHALLKDPFIQKLIDAEPVFWANSGKKEGPLPRADEW ATEIAEAEKRMQRFAPYIAEVFPETKGAKGIIESPLFEVQHMKGKLEAAYQQPFPGRW LLKCDHELPISGSIKARGGIYEVLKYAENLALQEGMLQETDDYRILQEERFTGFFSRY SIAVGSTGNLGLSIGIIGAALGFRVTVHMSADAKQWKKDLLRQKGVTVMEYETDYSEA VNEGRRQAEQDPFCYFIDDEHSRQLFLGYAVAASRLKTQLDCMNIKPSLETPLFVYLP CGVGGGPGGVAFGLKLLYGDDVHVFFAEPTHSPCMLLGLYSGLHEKISVQDIGLDNQT AADGLAVGRPSGFVGKLIEPLLSGCYTVEDNTLYTLLHMLAVSEDKYLEPSALAGMFG PVQLFSTEEGRRYAQKYKMEHAVHVVWGTGGSMVPKDEMAAYNRIGADLLKKRNEK*" /label="dsdA CDS" gene complement(1997185..1998531) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /label="dsdA gene" S_feature complement(1998532..1998606) /Source="Nicolas_S_feature" /locus_tag="new_2470927_2471001_c" /HighExp="C90, LBGtran, Diami, dia15, H2O2, dia5, G150, MG 15, GM-0.2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S901" CDS complement(1998607..1999386) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metabolite dehydrogenase, NAD-binding" /protein_id="NP_390259.1" /db_xref="EnsemblGenomes-Gn:BSU23780" /db_xref="EnsemblGenomes-Tr:CAB14310" /db_xref="GOA:P54554" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11746" /db_xref="UniProtKB/Swiss-Prot:P54554" /translation="MKHIAGKRIWITGASGGLGERIAYLCAAEGAHVLLSARREDRLI EIKRKITEEWSGQCEIFPLDVGRLEDIARVRDQIGSIDVLINNAGFGIFETVLDSTLD DMKAMFDVNVFGLIACTKAVLPQMLEQKKGHIINIASQAGKIATPKSSLYSATKHAVL GYSNALRMELSGTGIYVTTVNPGPIQTDFFSIADKGGDYAKNVGRWMLDPDDVAAQIT AAIFTKKREINLPRLMNAGTKLYQLFPALVEKLAGRALMKK*" /label="yqjQ CDS" gene complement(1998607..1999386) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /label="yqjQ gene" CDS complement(1999392..2000351) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390260.1" /db_xref="EnsemblGenomes-Gn:BSU23790" /db_xref="EnsemblGenomes-Tr:CAB14311" /db_xref="GOA:P54553" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11745" /db_xref="UniProtKB/Swiss-Prot:P54553" /translation="MTTEDVIAIRVPTPFAVGDVIVYLVKGDALTLIDAGPNTKEAAR ALQEQLAAVNVKLSDIEQVVLTHHHADHAGLLDVFSDEIEVIGHTFNEPYISQNQAFM DWQKRFFQKLLPELGVPFDTGKAEKLIRSAYAFSCTRSLTKSIREGMGIDGLEGWSVL EMPGHAESHIVLFHEKSGRMLGGDLLLANSSSNPILEAPKAGDVRSKPLVDYQRSLRR LSQLDPTIVFPGHGEPITSVQALIEKRFDKQRNRTEDVRRMLDEKPMTAFQVCQQLFP AVYEKELFLTMSETAGHLDVLEAEEAITSYWEGNTVYFKTMKR*" /label="yqjP CDS" gene complement(1999392..2000351) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /label="yqjP gene" promotor_-10 complement(2000373..2000392) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2000392) /Source="Nicolas_upshifts" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2000407..2000414) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2000448..2000455 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2000469..2000755 /Source="Nicolas_S_feature" /locus_tag="new_2472864_2473150" /HighExp="Diami, C90, BC, Paraq, G180, GM 15, Oxctl, S7, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S902" upshifts 2000469 /Source="Nicolas_upshifts" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2000471..2000490 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2000485..2000730 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /product="proline T-box riboswitch" /experiment="publication(s) with functional evidences, PMID:21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21233158" /label="pswI RNA" gene 2000485..2000730 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /label="pswI gene" CDS 2000756..2001592 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21233158, 28752945, 28824574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21233158, 28752945, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase (NADP-dependent, weak activity)" /protein_id="NP_390261.1" /db_xref="EnsemblGenomes-Gn:BSU23800" /db_xref="EnsemblGenomes-Tr:CAB14312" /db_xref="GOA:P54552" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11744" /db_xref="UniProtKB/Swiss-Prot:P54552" /translation="MKKIGFVGAGSMAEAMINGILQSGITKPEHIYITNRSNDERLIE LKETYSVRPCRDKNEFFTHTDIIILAFKPKDAAESIDSIRPYIKDQLVISVLAGLTIE TIQHYFGRKLAVIRVMPNTSAAIRKSATGFSVSTEASKNDIIAAKALLETIGDATLVE ERHLDAVTAIAGSGPAYVYRYIEAMEKAAQKVGLDKETAKALILQTMAGATDMLLQSG KQPEKLRKEITSPGGTTEAGLRALQDSRFEEAIIHCIEETAKRSAEIKEQFAGAALER HS*" /label="proI CDS" gene 2000756..2001592 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /label="proI gene" downshifts 2001590 /Source="Nicolas_upshifts" /id="D1238" /incds=0 /nref=29 /ntot=190 /MaxReadThrough="0.55696" /MaxDrop="3.78131" /score="36.2472665" /energy="-12" /TU="NA" /idTUdmin="U1859" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2001633..2003276) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase" /protein_id="NP_390262.2" /db_xref="EnsemblGenomes-Gn:BSU23810" /db_xref="EnsemblGenomes-Tr:CAB14313" /db_xref="GOA:P54551" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG11743" /db_xref="UniProtKB/Swiss-Prot:P54551" /translation="MNWQTKDELLALLTSLVQYESITGSKGEVALAEYLYFILKDKPY FQKHPDDVTLHPMDDGRSFLTALVKKKNVKKTVLLLSHFDVVDIEDYGEFKHMACKPA ELLSSFLEKKELLPERVRRDAESGDWLFGRGTMDMKAGLCIQLSMLERAMNGHFEGNL LLITVPDEEVNSRGMIEAVPALKEMEKKHDITLTACLNAEPMFEKFPGDQQQYFYTGS IGKVLAGFFCKGIETHVGEPFSGLNANLMVSEINRLLELNADYCEKVDGEVTPPPVNL MQKDLKEAYSVQTPHTAVTLFNVLSMKRSASELHQMLLKTAEQAAEEIMSNVRKKTQD FQQFEPFQPIERDVTVLTFDELVSRAKKRAGISETERALNYAFANRGELGDRDFSTKI VSELASLCKEDAPLIVLFYSPPLYPAVSSKDDQLIRNTADQIKHYAAERYGIALREVQ YFPGLSDLSYLQLEKQEVDAYTSNMPLFNRGYSLPSGKNQALYVPVLNVGPAGKDPHK WTERLYMPYSFEVLPDLLSFTISALLKQSESAGQLLREK*" /label="yqjN CDS" gene complement(2001633..2003276) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /label="yqjN gene" downshifts complement(2001645) /Source="Nicolas_upshifts" /id="D1239" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="2.2598" /MaxDrop="2.55609" /score="14.9380989" /energy="-12" /TU="NA" /idTUdmin="U1861" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2003294..2003300 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2003307 /Source="Nicolas_upshifts" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2003314..2003325 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2003332..2003351) /Source="Nicolas_upshift_promotors" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2003337) /Source="Nicolas_upshifts" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2003383..2003390 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2003404..2003423 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2003406 /Source="Nicolas_upshifts" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 2003448..2004464 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /EC_number="1.6.99.1" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12660247, 15249051, 15890652, 20011599, 20461254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12660247, 15249051, 15890652, 20011599, 20461254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent flavin oxidoreductase (acting oncinnamaldehyde-related compounds)" /protein_id="NP_390263.1" /db_xref="EnsemblGenomes-Gn:BSU23820" /db_xref="EnsemblGenomes-Tr:CAB14314" /db_xref="GOA:P54550" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023663" /db_xref="PDB:1Z41" /db_xref="PDB:1Z42" /db_xref="PDB:1Z44" /db_xref="PDB:1Z48" /db_xref="SubtiList:BG11742" /db_xref="UniProtKB/Swiss-Prot:P54550" /translation="MARKLFTPITIKDMTLKNRIVMSPMCMYSSHEKDGKLTPFHMAH YISRAIGQVGLIIVEASAVNPQGRITDQDLGIWSDEHIEGFAKLTEQVKEQGSKIGIQ LAHAGRKAELEGDIFAPSAIAFDEQSATPVEMSAEKVKETVQEFKQAAARAKEAGFDV IEIHAAHGYLIHEFLSPLSNHRTDEYGGSPENRYRFLREIIDEVKQVWDGPLFVRVSA SDYTDKGLDIADHIGFAKWMKEQGVDLIDCSSGALVHADINVFPGYQVSFAEKIREQA DMATGAVGMITDGSMAEEILQNGRADLIFIGRELLRDPFFARTAAKQLNTEIPAPVQY ERGW*" /label="yqjM CDS" gene 2003448..2004464 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /label="yqjM gene" downshifts 2004451 /Source="Nicolas_upshifts" /id="D1240" /incds=0 /nref=42 /ntot=157 /MaxReadThrough="2.79686" /MaxDrop="5.04803" /score="39.119339" /energy="-12.8" /TU="U1862" /idTUdmin="U1862" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 2004513..2004522 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2004535..2004550 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2004539 /Source="Nicolas_upshifts" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 2004574..2005335 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390264.1" /db_xref="EnsemblGenomes-Gn:BSU23830" /db_xref="EnsemblGenomes-Tr:CAB14315" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11741" /db_xref="UniProtKB/Swiss-Prot:P54549" /translation="MKSAWMEKTYTIDGCAFHTQHRKGSSGVTIVFEAGYGTSSETWK PLMADIDDEFGIFTYDRAGIGKSGQSRAKRTADQQVKELESLLKAADVKPPYLAVSHS YGAVITGLWACKNKHDIIGMVLLDPALGDCASFTFIPEEMHKSHTRKMMLEGTHAEFS KSLQELKKRQVHLGNMPLLVLSSGERTEKFAAEQEWQNLHSSILSLSNQSGWIQAKNS SHNIHHDEPHIVHLAIYDVWCAACQQAAPLYQAVN*" /label="yqjL CDS" gene 2004574..2005335 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /label="yqjL gene" downshifts 2005243 /Source="Nicolas_upshifts" /id="D1241" /incds=1 /nref=21 /ntot=204 /MaxReadThrough="3.34804" /MaxDrop="3.21955" /score="0.451826768" /energy="-11.2" /TU="U1863" /idTUdmin="U1862" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 2005331 /Source="Nicolas_upshifts" /id="D1242" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="1.34151" /MaxDrop="3.85711" /score="0.451826768" /energy="-11.2" /TU="NA" /idTUdmin="U1863" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2005363..2005563) /Source="Nicolas_S_feature" /locus_tag="new_2477758_2477958_c" /HighExp="B60, S5, Etha, S4, B36, BMM, Heat, S3, S2, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.21631400000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S903" CDS complement(2005379..2005504) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33* pseudogene" /translation="CTETGDRNYITTKNKRTNPDRLELKKYSPRLKKYTLHRETK*" /label="rpmGCc CDS" gene complement(2005379..2005504) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /pseudo /label="rpmGCc gene" downshifts complement(2005406) /Source="Nicolas_upshifts" /id="D1243" /incds=0 /nref=187 /ntot=264 /MaxReadThrough="3.91531" /MaxDrop="7.65732" /score="5.23287853" /energy="-8.8" /TU="U1864" /idTUdmin="U1865" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2005497..2005529) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 19648245, 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33C pseudogene" /db_xref="PSEUDO:CCQ48601.1" /translation="MRVNVTLALH*" /label="rpmGCn CDS" gene complement(2005497..2005529) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /pseudo /label="rpmGCn gene" promotor_-10 complement(2005557..2005576) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2005563) /Source="Nicolas_upshifts" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2005589..2005596) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2005611..2006534) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /EC_number="3.1.26.11" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 12941704, 16336119, 17005971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12941704, 16336119, 17005971; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease Z" /protein_id="NP_390265.1" /db_xref="EnsemblGenomes-Gn:BSU23840" /db_xref="EnsemblGenomes-Tr:CAB14316" /db_xref="GOA:P54548" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR013471" /db_xref="InterPro:IPR036866" /db_xref="PDB:1Y44" /db_xref="PDB:2FK6" /db_xref="PDB:4GCW" /db_xref="SubtiList:BG11740" /db_xref="UniProtKB/Swiss-Prot:P54548" /translation="MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQH QILHTTIKPRKIEKIFITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFIET SLAVTKTHLTYPLAIQEIEEGIVFEDDQFIVTAVSVIHGVEAFGYRVQEKDVPGSLKA DVLKEMNIPPGPVYQKIKKGETVTLEDGRIINGNDFLEPPKKGRSVVFSGDTRVSDKL KELARDCDVLVHEATFAKEDRKLAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQG DASLELQKEAVDVFPNSVAAYDFLEVNVPRG*" /label="rnz CDS" gene complement(2005611..2006534) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /label="rnz gene" promotor_-10 complement(2006560..2006579) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2006573) /Source="Nicolas_upshifts" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2006593..2006598) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2006672..2006679 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2006693..2006712 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2006695..2006760 /Source="Nicolas_S_feature" /locus_tag="new_2479090_2479155" /HighExp="dia5, C90, MG 5, Lbexp, MG t5, MG 45, M9-exp, GM 90, GM 120, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S904" upshifts 2006695 /Source="Nicolas_upshifts" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="upshifts" CDS 2006761..2008230 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /EC_number="1.1.1.49" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1704005, 19779711, 26129872" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1704005, 19779711, 26129872; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate 1-dehydrogenase (NADP-dependent)" /protein_id="NP_390266.2" /db_xref="EnsemblGenomes-Gn:BSU23850" /db_xref="EnsemblGenomes-Tr:CAB14317" /db_xref="GOA:P54547" /db_xref="InterPro:IPR001282" /db_xref="InterPro:IPR019796" /db_xref="InterPro:IPR022674" /db_xref="InterPro:IPR022675" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11739" /db_xref="UniProtKB/Swiss-Prot:P54547" /translation="MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAV VGVGRRPWSNEDLRQTVKTSISSSADKHIDDFTSHFYYHPFDVTNPGSYQELNVLLNQ LEDTYQIPNNRMFYLAMAPEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQA LNKEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSES LGVEDRARYYEKSGALRDMVQNHIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPI AKDEVDEYFVRGQYHAGEIDGVPVPAYTDEDNVAPDSNTETFVAGKLLIDNFRWAGVP FYIRTGKRMKEKSTKIVVQFKDIPMNLYYGNENNMNPNLLVIHIQPDEGITLYLNAKK LGGAAHAQPIKLDYCSNCNDELNTPEAYEKLIHDCLLGDATNFAHWDEVALSWSFVDS ISETWAANKTLSPNYESGSMGPKESDDLLVKDGLHWWNI*" /label="zwf CDS" gene 2006761..2008230 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /label="zwf gene" downshifts 2008213 /Source="Nicolas_upshifts" /id="D1244" /incds=0 /nref=206 /ntot=286 /MaxReadThrough="3.46838" /MaxDrop="7.76173" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" terminator 2008238..2008277 /created_by="User" /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" /label="Delta6_zwf-T-gndA_Terminator" Polymorphism join(2008250,2008253) /Source="geneious" /ID="SNP_BsDelta6_2480646_2480647" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="TA -> AT" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TA" /Variant_Nucleotides="AT" /Variant_P_Value=0 /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(2008258,2008259) /Source="geneious" /ID="SNP_BsDelta6_2480654_2480654" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.1e-279" /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(2008270,2008271) /Source="geneious" /ID="SNP_BsDelta6_2480667_2480667" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=116 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.9e-244" /Variant_Raw_Frequency=110 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2008279 /Source="Nicolas_upshifts" /id="D1245" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="2.5392" /MaxDrop="4.74183" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2008353..2009762) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /EC_number="1.1.1.44" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 15755726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 15755726; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP+-dependent 6-P-gluconate dehydrogenase" /protein_id="NP_390267.2" /db_xref="EnsemblGenomes-Gn:BSU23860" /db_xref="EnsemblGenomes-Tr:CAB14318" /db_xref="GOA:P80859" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11738" /db_xref="UniProtKB/Swiss-Prot:P80859" /translation="MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQ EAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGN TYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVF AEWNKGELDSYLIEITADIFTKKDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVP LPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIEAVRKALFMSKICSY AQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDS YFKNIVESYQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFG AHTYERTDKEGIFHTEWMK*" /label="gndA CDS" gene complement(2008353..2009762) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /label="gndA gene" downshifts complement(2008370) /Source="Nicolas_upshifts" /id="D1246" /incds=0 /nref=220 /ntot=361 /MaxReadThrough="1.88983" /MaxDrop="8.82894" /score="24.3727084" /energy="-18" /TU="NA" /idTUdmin="U1867" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" downshifts complement(2008443) /Source="Nicolas_upshifts" /id="D1247" /incds=1 /nref=1 /ntot=36 /MaxReadThrough="8.40595" /MaxDrop="2.3555" /score="24.3727084" /energy="-18" /TU="U1867" /idTUdmin="U1867" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" misc_feature complement(2009826..2009844) /Source="Nicolas_upshift_promotors" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2009828) /Source="Nicolas_upshifts" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2009872..2011116) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /EC_number="2.7.7.7" /function="16.6: Maintain" /function="16.5: Explore" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-damage lesion bypass DNA polymerase" /protein_id="NP_390268.2" /db_xref="EnsemblGenomes-Gn:BSU23870" /db_xref="EnsemblGenomes-Tr:CAB14319" /db_xref="GOA:P54545" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017061" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11737" /db_xref="UniProtKB/Swiss-Prot:P54545" /translation="MPGKSRIIFHIDMNSFYASVEMAYDPALRGKPVAVAGNVKERKG IVVTCSYEARARGVKTTMPVWQAKRHCPELIVLPPNFDRYRNSSRAMFTILREYTDLV EPVSIDEGYMDMTDTPYSSRALETAKEIQSRLQKELLLPSSIGIAPNKFLAKMASDMK KPLGITILRKRQVPDILWPLPVGEMHGVGKKTAEKLKGLGIHTIGELAAADEHSLKRL LGINGPRLKNKANGIHHAPVDPERIYEFKSVGNSSTLSHDSSDEEELLGVFRKLAASV SDRLQRKEVMASKLFIMIRYADWRTITRSTTLRNPIDQKNDILKEAEHLFFKHWNKNP VRLLGITGTDLVEKEQAYKQLDLFSFNEDAKDEPIQQMMEKLNKKYGTKLIRKGATLK KEESKTKGTSFNKDFFQDEKKS*" /label="polYA CDS" gene complement(2009872..2011116) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /label="polYA gene" S_feature complement(2011117..2011391) /Source="Nicolas_S_feature" /locus_tag="new_2483514_2483788_c" /HighExp="M40t90, Sw, M40t45, H2O2, C30, Cold, Etha, C90, Diami, BC" /AntisenseName="yqzJ" /AntisenseCor="0.48883700687558601" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S905" promotor_-35 2011137..2011144 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2011158..2011177 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2011158 /Source="Nicolas_upshifts" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="upshifts" CDS 2011189..2011476 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /experiment="publication(s) with functional evidences, PMID:19779460, 21383133, 22720735, 25313395, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19779460, 21383133, 22720735, 25313395, 25903689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of OxaAB translation" /protein_id="YP_054586.1" /db_xref="EnsemblGenomes-Gn:BSU23880" /db_xref="EnsemblGenomes-Tr:CAE01460" /db_xref="GOA:Q7WY64" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG14191" /db_xref="UniProtKB/Swiss-Prot:Q7WY64" /translation="MTMFVESINDVLFLVDFFTIILPALTAIGIAFLLRECRAGEQWK SKRTDEHQTVFHINRTDFLIIIYHRITTWIRKVFRMNSPVNDEEDAGSLLL*" /label="mifM CDS" gene 2011189..2011476 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /label="mifM gene" promotor_-10 complement(2011373..2011392) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-10" upshifts complement(2011393) /Source="Nicolas_upshifts" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="upshifts" promotor_-35 complement(2011408..2011411) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-35" CDS 2011507..2012334 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_390269.1" /db_xref="EnsemblGenomes-Gn:BSU23890" /db_xref="EnsemblGenomes-Tr:CAB14320" /db_xref="GOA:P54544" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG11736" /db_xref="UniProtKB/Swiss-Prot:P54544" /translation="MLKTYQKLLAMGIFLIVLCSGNAAFAATNQVGGLSNVGFFHDYL IEPFSALLKGVAGLFHGEYGLSIILVTIIVRIVVLPLFVNQFKKQRIFQEKMAVIKPQ VDSIQVKLKKTKDPEKQKELQMEMMKLYQEHNINPLAMGCLPMLIQSPIMIGLYYAIR STPEIASHSFLWFSLGQSDILMSLSAGIMYFVQAYIAQKLSAKYSAVPQNPAAQQSAK LMVFIFPVMMTIFSLNVPAALPLYWFTSGLFLTVQNIVLQMTHHKSKKTAALTESVK* " /label="oxaAB CDS" gene 2011507..2012334 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /label="oxaAB gene" downshifts 2012151 /Source="Nicolas_upshifts" /id="D1248" /incds=1 /nref=4 /ntot=125 /MaxReadThrough="5.05074" /MaxDrop="3.49092" /score="-5.67811369" /energy="-7.6" /TU="U1868" /idTUdmin="U1868" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2012327 /Source="Nicolas_upshifts" /id="D1249" /incds=0 /nref=71 /ntot=229 /MaxReadThrough="1.09826" /MaxDrop="6.56698" /score="-5.67811369" /energy="-7.6" /TU="NA" /idTUdmin="U1868" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2012339..2013259) /Source="Nicolas_S_feature" /locus_tag="new_2484736_2485656_c" /HighExp="LoTm, B36, M0t90, M40t90, Lbstat, M9-stat, T1.30H, B60, LBGtran, BT" /AntisenseName="yqjF" /AntisenseCor="0.18628881890353799" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S906" downshifts complement(2012382) /Source="Nicolas_upshifts" /id="D1250" /incds=0 /nref=170 /ntot=248 /MaxReadThrough="0.24428" /MaxDrop="6.31082" /score="18.1943524" /energy="-12.4" /TU="NA" /idTUdmin="U1871" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2012452..2012458 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2012472..2012490 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2012481 /Source="Nicolas_upshifts" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="upshifts" CDS 2012514..2013242 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390270.3" /db_xref="EnsemblGenomes-Gn:BSU23900" /db_xref="EnsemblGenomes-Tr:CAB14321" /db_xref="InterPro:IPR018644" /db_xref="InterPro:IPR023375" /db_xref="SubtiList:BG11735" /db_xref="UniProtKB/Swiss-Prot:P54543" /translation="MTERFQQKNISVPDGIWIMRQTWNDVLFAHWPVDVSILRALVPS VLELDTYNGQAWISMLPFMLTNLRARYLPVIPGARAFPELNLRTYVTYKGKPGIYFFS LDADHRLAVLGARTFFHLPYFYADMKSEKNGDAIDYVSKRKNDKEAAFHAAYRPISAP FTAEKDSLDYWLTERYRLYTTYRNKLYYEDIHHHPWLLQNAEAEISVNTVTDAHGITL PESDPLLHYAKKQDVLFWPLRKWS*" /label="yqjF CDS" gene 2012514..2013242 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /label="yqjF gene" CDS complement(2013283..2014398) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase or deacylase" /protein_id="NP_390271.2" /db_xref="EnsemblGenomes-Gn:BSU23910" /db_xref="EnsemblGenomes-Tr:CAB14322" /db_xref="GOA:P54542" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR010162" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11734" /db_xref="UniProtKB/Swiss-Prot:P54542" /translation="MVNEKRLLEEFLELVQIDSETKHEAEICKVLKRKFSDLGVDVKE DDTMDITGHGAGNLICTLKGTKQTDTIYFTSHMDTVVPGNGVKPVVENGYVKTDGTTI LGADDKAGLAAMFEAIKVLKEENIEHGTIEFIITVGEESGLIGAKALDRSMITASYGY ALDSDGKVGNIIVAAPTQAKVRAAIFGKTAHAGVEPEKGISAITIASKAISKMPLGRI DEETTANIGRFEGGTQTNIVCDEVHILAEARSLVPEKMEAQVQKMKAAFEEAAADMGG RAEVEIEVMYPGFKYQDGDQVVEIAKKAAAKIGRPSELQTSGGGSDANVIAGHGIPTV NLAVGYEQIHTKNEKMPIEELVKTAEMVVAIIEEAAK*" /label="yqjE CDS" gene complement(2013283..2014398) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /label="yqjE gene" downshifts complement(2013304) /Source="Nicolas_upshifts" /id="D1251" /incds=0 /nref=23 /ntot=203 /MaxReadThrough="3.90071" /MaxDrop="3.95711" /score="11.6635037" /energy="-10.6" /TU="U1871" /idTUdmin="U1871" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" CDS complement(2014416..2015939) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /EC_number="6.4.1.3" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative propionyl-CoA carboxylase beta chain" /protein_id="NP_390272.2" /db_xref="EnsemblGenomes-Gn:BSU23920" /db_xref="EnsemblGenomes-Tr:CAB14323" /db_xref="GOA:P54541" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG11733" /db_xref="UniProtKB/Swiss-Prot:P54541" /translation="MNEHMDHFYTKRKQAEEGGGREKLAQQRQKGKLTARERIIFLLD QDSFIELHPFMESQVLTREQRMLGDGVVTGYGTIDGRSVYVFAQDFTVYGGALGETHA RKICALMDLAAKNKAPIIGLNDSGGARIQEGVLSLDGYGHIFYRNVLYSGVIPQISVI LGPCAGGAVYSPALTDFIFMAEQTGRMFITGPKVIEKVTGEQVDAESLGGAGIHNAVS GNAHFSGHTEKEVLTGVRKLLSYLPLNGRTTEPKPEKEASRPLLNRLVPADTTKPYDV RKVIRELADPQSFFEIQPFFAKNIVIGFARLGEKAIGIVASQPKHLAGSLTIDAADKA ARFIRFCDAFDIPLLTVEDVPGFLPGIQQEHNGIIRHGAKLLFAYAEATVPKVTLIIR KAYGGAYVAMNSKAIGADLVFAWPNAEIAVMGPEGAASILYEKEIKASADPQKTKREK TAEYKKQNAGPYKAAACGMVDDIILPEESRGRLIQAFHMLTHKTEERPKKKHGNIPL* " /label="yqjD CDS" gene complement(2014416..2015939) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /label="yqjD gene" promotor_-10 complement(2015522..2015541) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2015544) /Source="Nicolas_upshifts" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2015556..2015560) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2015932..2016354) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /EC_number="5.1.99.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methylmalonyl-CoA epimerase" /protein_id="NP_390273.2" /db_xref="EnsemblGenomes-Gn:BSU23930" /db_xref="EnsemblGenomes-Tr:CAB14324" /db_xref="GOA:P54540" /db_xref="InterPro:IPR017515" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11732" /db_xref="UniProtKB/Swiss-Prot:P54540" /translation="MNRLDHIGIAVFSIKDARSFYENVLGLAFLHQETVEEQKVNVAF FQAGSVKLELIEPLTADSPVHLFLEKKGQGLHHIAFLCNCLSEQLQALSDQHVQLIDR FPRQGANGKKIAFISPRETNGVLVELCEPKGDQHNEHE*" /label="yqjC CDS" gene complement(2015932..2016354) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /label="yqjC gene" promotor_-35 2016383..2016390 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2016404..2016423 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2016418..2016571 /Source="Nicolas_S_feature" /locus_tag="new_2488815_2488968" /HighExp="LPhT, Etha, dia15, Salt, M9-stat, LBGstat, Heat, BC, T-0.40H, HiOs" /AntisenseName="yqjB" /AntisenseCor="-0.57221813594264503" /AntisenseRegPval="-24.1" /CDS_PredictionProba="0.99822200000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S907" upshifts 2016418 /Source="Nicolas_upshifts" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="upshifts" downshifts 2016528 /Source="Nicolas_upshifts" /id="D1252" /incds=0 /nref=1 /ntot=140 /MaxReadThrough="3.88708" /MaxDrop="3.25163" /score="3.10927996" /energy="-7" /TU="U1872" /idTUdmin="U1872" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" CDS complement(2016556..2017086) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /EC_number="2.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative L,D-transpeptidase" /protein_id="NP_390274.1" /db_xref="EnsemblGenomes-Gn:BSU23940" /db_xref="EnsemblGenomes-Tr:CAB14325" /db_xref="GOA:P54539" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG11731" /db_xref="UniProtKB/Swiss-Prot:P54539" /translation="MRFFLCSIFMMISPIWPLGENPLPGDPYVIVNKRTNELAVILDN KVEGVYSVATGKTDDLTPEGEFSVTVKAENPYYRKKNIEGGSPDNPLGARWIGFDAKG TDGRIYGIHGTNREESVGKFVSNGCIRMHNDEVVHLFQTIPVGTRVLITDDNRSFEEI AIEHKALIKKQDIPIE*" /label="yqjB CDS" gene complement(2016556..2017086) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /label="yqjB gene" S_feature 2016573..2017208 /Source="Nicolas_S_feature" /locus_tag="new_2488970_2489605" /HighExp="LPhT, H2O2, BC, Salt, dia15, M9-stat, Heat, LBGstat, T5.0H, Etha" /AntisenseName="yqjB" /AntisenseCor="-0.31126010332536502" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S908" promotor_-10 complement(2017103..2017114) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2017110) /Source="Nicolas_upshifts" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2017129..2017135) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2017138..2018106) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390275.2" /db_xref="EnsemblGenomes-Gn:BSU23950" /db_xref="EnsemblGenomes-Tr:CAB14326" /db_xref="GOA:P54538" /db_xref="InterPro:IPR010343" /db_xref="InterPro:IPR021062" /db_xref="SubtiList:BG11730" /db_xref="UniProtKB/Swiss-Prot:P54538" /translation="MFKIGYRTIKTALGTALAIYISQLLHLQNFASAGIITILCIQIT QKRSLQASWARFSACCLAIAFSYLFFELIGYHPFVIGALLLIFIPITVLLKINEGIVT SSVIILHLYMSGGITPTFIWNEVQLITVGIGVALLMNLYMPSLDRKLIAYRKKIEDNF AVIFAEIERYLLTGEQDWSGKEIPETHQLITEAKNLAYRDVQNHILRYENLHYHYFKM REKQFEIIERLLPKVTSISITVDQGKMIAEFIHDLREAIHPGNTAYKFLKRLADMRKE FEEMPLPATREEFEARAALFHLLGEMEQYLVIKSYFKGIKAQKSLG*" /label="yqjA CDS" gene complement(2017138..2018106) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /label="yqjA gene" downshifts complement(2017154) /Source="Nicolas_upshifts" /id="D1253" /incds=0 /nref=79 /ntot=223 /MaxReadThrough="2.22356" /MaxDrop="3.94894" /score="1.98299685" /energy="-14.1" /TU="NA" /idTUdmin="U1874" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2018177..2018899) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (ATP-binding protein)" /protein_id="NP_390276.1" /db_xref="EnsemblGenomes-Gn:BSU23960" /db_xref="EnsemblGenomes-Tr:CAB14327" /db_xref="GOA:P54537" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11729" /db_xref="UniProtKB/Swiss-Prot:P54537" /translation="MIKVEKLSKSFGKHEVLKNISTTIAEGEVVAVIGPSGSGKSTFL RCLNLLEKPNGGTITIKDTEITKPKTNTLKVRENIGMVFQHFHLFPHKTVLENIMYAP VNVKKESKQAAQEKAEDLLRKVGLFEKRNDYPNRLSGGQKQRVAIARALAMNPDIMLF DEPTSALDPEMVKEVLQVMKELVETGMTMVIVTHEMGFAKEVADRVLFMDQGMIVEDG NPKEFFMSPKSKRAQDFLEKIL*" /label="artR CDS" gene complement(2018177..2018899) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /label="artR gene" downshifts complement(2018188) /Source="Nicolas_upshifts" /id="D1254" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="4.81216" /MaxDrop="4.0342" /score="0.346345754" /energy="-7" /TU="U1874" /idTUdmin="U1874" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS complement(2018892..2019551) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (permease)" /protein_id="NP_390277.1" /db_xref="EnsemblGenomes-Gn:BSU23970" /db_xref="EnsemblGenomes-Tr:CAB14328" /db_xref="GOA:P54536" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11728" /db_xref="UniProtKB/Swiss-Prot:P54536" /translation="MNLDFSATIPQIPFILEGLAITLKIVVVSAIIGLILGIVLSLCK ISTFRPFIWIADFYTSVFRGTPLVLQLMIVYFGLPQLLGFQIDQFWAAVVALSLNSAA YVSEIIRAGINAIDKGQKEAAVALGVPYGKMMKDLLLPQAFKNISPAIVNELITLTKE SAIVTVIGLGDVMRRAYQAGAATYNYLEPLIIAGLIYYVLVLILTFIGKAVERKLKSN D*" /label="artQ CDS" gene complement(2018892..2019551) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /label="artQ gene" S_feature complement(2019552..2019631) /Source="Nicolas_S_feature" /locus_tag="new_2491949_2492028_c" /HighExp="S1, S2, ferm, MG 15, Fru, Glu, BMM, S3, UNK1, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S909" CDS complement(2019632..2020399) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter binding lipoprotein" /protein_id="NP_390278.1" /db_xref="EnsemblGenomes-Gn:BSU23980" /db_xref="EnsemblGenomes-Tr:CAB14329" /db_xref="GOA:P54535" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11727" /db_xref="UniProtKB/Swiss-Prot:P54535" /translation="MKKWLLLLVAACITFALTACGSSNSGSESGKKKLIMGTSADYKP FEYKEGDNIVGFDVELAKALAKKAGYEIEVQDMDFNSLITALKSKQVDLVLSGMTPTP ERKKQVDFSDVYYTANHMIVSKKDSGIQSLKDLKGKTVGVQLGSIQEEKGKELSPEYG FKTEDRNRISDLVQEIKSDRFDAAIIEDIVAEGYFKSNDDLQGFVIPDAKAEEAGSAI AFRKDSELTDKFNKALKEMEDNGELEKLKKKWFTGEK*" /label="artP CDS" gene complement(2019632..2020399) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /label="artP gene" promotor_-10 complement(2020449..2020468) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2020464) /Source="Nicolas_upshifts" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2020483..2020490) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2020667..2021104) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /experiment="publication(s) with functional evidences, PMID:21749987, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21749987, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin B (de-bacillithiolation)" /protein_id="NP_390279.1" /db_xref="EnsemblGenomes-Gn:BSU23990" /db_xref="EnsemblGenomes-Tr:CAB14330" /db_xref="InterPro:IPR009474" /db_xref="SubtiList:BG11726" /db_xref="UniProtKB/Swiss-Prot:P54534" /translation="MNMDFNLFMNDIVRQARQEITAAGYTELKTAEEVDEALTKKGTT LVMVNSVCGCAGGIARPAAYHSVHYDKRPDQLVTVFAGQDKEATARARDYFEGYPPSS PSFAILKDGKIMKMVERHEIEGHEPMAVVAKLQEAFEEYCEEV*" /label="brxB CDS" gene complement(2020667..2021104) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /label="brxB gene" downshifts complement(2020676) /Source="Nicolas_upshifts" /id="D1255" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="3.9242" /MaxDrop="7.06654" /score="21.489397" /energy="-11.8" /TU="U1875" /idTUdmin="U1875" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2021128..2021147) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-10" upshifts complement(2021149) /Source="Nicolas_upshifts" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="upshifts" promotor_-35 complement(2021162..2021169) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-35" promotor_-35 2021202..2021208 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2021221 /Source="Nicolas_upshifts" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2021223..2021241 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2021265..2022158 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /EC_number="2.7.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7961792, 8098708, 10220166, 17114254, 17535816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipid kinase BmrU" /protein_id="NP_390280.2" /db_xref="EnsemblGenomes-Gn:BSU24000" /db_xref="EnsemblGenomes-Tr:CAB14331" /db_xref="GOA:P39074" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG10302" /db_xref="UniProtKB/Swiss-Prot:P39074" /translation="MSHRKALLIHNGNAGNKNIEKALGAVVPVLSHHLDEVIIKQTKK KDDAYHFCRSIDDSVDTVFILGGDGTIHQCINAISALERKPAVGILPGGTCNDFSRVL GIPQNLAKAAEALMAGKKTSVDVCQMNDRYFLNFWGIGLIAETSNQINETEKALLGKI SYFTSALRTVSSAASFPMTLKIDGEEIKEEAVMLLVMNGQYIGTNRIPLPDASIEDGL LDVLICRNTNLTALRELMSMEQGSIDRFTGELSYVQASRIEIETDTAKKADMDGEVYT HTPAVIQVLPQHIDMLVPANE*" /label="bmrU CDS" gene 2021265..2022158 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /label="bmrU gene" promotor_-35 2022191..2022198 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2022214..2022233 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2022222 /Source="Nicolas_upshifts" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" CDS 2022259..2023428 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10200972, 10961951, 11321573, 15849754, 16850406, 25756668" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10961951, 11321573, 15849754, 16850406, 25756668; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_390281.2" /db_xref="EnsemblGenomes-Gn:BSU24010" /db_xref="EnsemblGenomes-Tr:CAB14332" /db_xref="GOA:P33449" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10303" /db_xref="UniProtKB/Swiss-Prot:P33449" /translation="MEKKNITLTILLTNLFIAFLGIGLVIPVTPTIMNELHLSGTAVG YMVACFAITQLIVSPIAGRWVDRFGRKIMIVIGLLFFSVSEFLFGIGKTVEMLFISRM LGGISAAFIMPGVTAFIADITTIKTRPKALGYMSAAISTGFIIGPGIGGFLAEVHSRL PFFFAAAFALLAAILSILTLREPERNPENQEIKGQKTGFKRIFAPMYFIAFLIILISS FGLASFESLFALFVDHKFGFTASDIAIMITGGAIVGAITQVVLFDRFTRWFGEIHLIR YSLILSTSLVFLLTTVHSYVAILLVTVTVFVGFDLMRPAVTTYLSKIAGNEQGFAGGM NSMFTSIGNVFGPIIGGMLFDIDVNYPFYFATVTLAIGIALTIAWKAPAHLKAST*" /label="bmr CDS" gene 2022259..2023428 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /label="bmr gene" downshifts 2023411 /Source="Nicolas_upshifts" /id="D1256" /incds=0 /nref=6 /ntot=31 /MaxReadThrough="4.82186" /MaxDrop="5.02667" /score="-1.94257488" /energy="-18" /TU="U1876,U1877" /idTUdmin="U1876" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" CDS 2023501..2024337 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11201751, 11839496, 12682015, 14985361, 18658145, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11201751, 11839496, 12682015, 14985361, 18658145, 21690368; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family)" /protein_id="NP_390282.2" /db_xref="EnsemblGenomes-Gn:BSU24020" /db_xref="EnsemblGenomes-Tr:CAB14333" /db_xref="GOA:P39075" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="PDB:1BOW" /db_xref="PDB:1EXI" /db_xref="PDB:1EXJ" /db_xref="PDB:1R8E" /db_xref="PDB:2BOW" /db_xref="PDB:3D6Y" /db_xref="PDB:3D6Z" /db_xref="PDB:3D70" /db_xref="PDB:3D71" /db_xref="PDB:3IAO" /db_xref="PDB:3Q1M" /db_xref="PDB:3Q2Y" /db_xref="PDB:3Q3D" /db_xref="PDB:3Q5P" /db_xref="PDB:3Q5R" /db_xref="PDB:3Q5S" /db_xref="SubtiList:BG10304" /db_xref="UniProtKB/Swiss-Prot:P39075" /translation="MKESYYSIGEVSKLANVSIKALRYYDKIDLFKPAYVDPDTSYRY YTDSQLIHLDLIKSLKYIGTPLEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALE QTISLVKKRMKRQMEYPALGEVFVLDEEEIRIIQTEAEGIGPENVLNASYSKLKKFIE SADGFTNNSYGATFSFQPYTSIDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRYA CIAYNFSPEHYFLNLQKLIKYIADRQLTVVSDVYELIIPIHYSPKKQEEYRVEMKIRI AE*" /label="bmrR CDS" gene 2023501..2024337 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /label="bmrR gene" downshifts 2024335 /Source="Nicolas_upshifts" /id="D1257" /incds=0 /nref=5 /ntot=156 /MaxReadThrough="4.1979" /MaxDrop="4.72542" /score="5.00815505" /energy="-15.7" /TU="NA" /idTUdmin="U1876" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2024399) /Source="Nicolas_upshifts" /id="D1258" /incds=0 /nref=15 /ntot=247 /MaxReadThrough="3.01431" /MaxDrop="6.04069" /score="8.5296919" /energy="-16.8" /TU="U1879" /idTUdmin="U1878" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2024399..2025673) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /EC_number="2.3.1.168" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase)" /protein_id="NP_390283.1" /db_xref="EnsemblGenomes-Gn:BSU24030" /db_xref="EnsemblGenomes-Tr:CAB14334" /db_xref="GOA:P37942" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10305" /db_xref="UniProtKB/Swiss-Prot:P37942" /translation="MAIEQMTMPQLGESVTEGTISKWLVAPGDKVNKYDPIAEVMTDK VNAEVPSSFTGTITELVGEEGQTLQVGEMICKIETEGANPAEQKQEQPAASEAAENPV AKSAGAADQPNKKRYSPAVLRLAGEHGIDLDQVTGTGAGGRITRKDIQRLIETGGVQE QNPEELKTAAPAPKSASKPEPKEETSYPASAAGDKEIPVTGVRKAIASNMKRSKTEIP HAWTMMEVDVTNMVAYRNSIKDSFKKTEGFNLTFFAFFVKAVAQALKEFPQMNSMWAG DKIIQKKDINISIAVATEDSLFVPVIKNADEKTIKGIAKDITGLAKKVRDGKLTADDM QGGTFTVNNTGSFGSVQSMGIINYPQAAILQVESIVKRPVVMDNGMIAVRDMVNLCLS LDHRVLDGLVCGRFLGRVKQILESIDEKTSVY*" /label="bkdB CDS" gene complement(2024399..2025673) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /label="bkdB gene" CDS complement(2025696..2026679) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /EC_number="1.2.4.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390284.1" /db_xref="EnsemblGenomes-Gn:BSU24040" /db_xref="EnsemblGenomes-Tr:CAB14335" /db_xref="GOA:P37941" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10306" /db_xref="UniProtKB/Swiss-Prot:P37941" /translation="MSVMSYIDAINLAMKEEMERDSRVFVLGEDVGRKGGVFKATAGL YEQFGEERVMDTPLAESAIAGVGIGAAMYGMRPIAEMQFADFIMPAVNQIISEAAKIR YRSNNDWSCPIVVRAPYGGGVHGALYHSQSVEAIFANQPGLKIVMPSTPYDAKGLLKA AVRDEDPVLFFEHKRAYRLIKGEVPADDYVLPIGKADVKREGDDITVITYGLCVHFAL QAAERLEKDGISAHVVDLRTVYPLDKEAIIEAASKTGKVLLVTEDTKEGSIMSEVAAI ISEHCLFDLDAPIKRLAGPDIPAMPYAPTMEKYFMVNPDKVEAAMRELAEF*" /label="bkdAB CDS" gene complement(2025696..2026679) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /label="bkdAB gene" CDS complement(2026693..2027685) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /EC_number="1.2.4.4" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390285.1" /db_xref="EnsemblGenomes-Gn:BSU24050" /db_xref="EnsemblGenomes-Tr:CAB14336" /db_xref="GOA:P37940" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR034616" /db_xref="SubtiList:BG10307" /db_xref="UniProtKB/Swiss-Prot:P37940" /translation="MSTNRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPF VISCQGQEAAQVGAAFALDREMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNS GGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQG DFHEGANFAAVHKLPVIFMCENNKYAISVPYDKQVACENISDRAIGYGMPGVTVNGND PLEVYQAVKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEEAKKSDPL LTYQAYLKETGLLSDEIEQTMLDEIMAIVNEATDEAENAPYAAPESALDYVYAK*" /label="bkdAA CDS" gene complement(2026693..2027685) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /label="bkdAA gene" CDS complement(2027707..2029131) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /EC_number="1.8.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase)" /protein_id="NP_390286.2" /db_xref="EnsemblGenomes-Gn:BSU24060" /db_xref="EnsemblGenomes-Tr:CAB14337" /db_xref="GOA:P54533" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11725" /db_xref="UniProtKB/Swiss-Prot:P54533" /translation="MATEYDVVILGGGTGGYVAAIRAAQLGLKTAVVEKEKLGGTCLH KGCIPSKALLRSAEVYRTAREADQFGVETAGVSLNFEKVQQRKQAVVDKLAAGVNHLM KKGKIDVYTGYGRILGPSIFSPLPGTISVERGNGEENDMLIPKQVIIATGSRPRMLPG LEVDGKSVLTSDEALQMEELPQSIIIVGGGVIGIEWASMLHDFGVKVTVIEYADRILP TEDLEISKEMESLLKKKGIQFITGAKVLPDTMTKTSDDISIQAEKDGETVTYSAEKML VSIGRQANIEGIGLENTDIVTENGMISVNESCQTKESHIYAIGDVIGGLQLAHVASHE GIIAVEHFAGLNPHPLDPTLVPKCIYSSPEAASVGLTEDEAKANGHNVKIGKFPFMAI GKALVYGESDGFVKIVADRDTDDILGVHMIGPHVTDMISEAGLAKVLDATPWEVGQTI HPHPTLSEAIGEAALAADGKAIHF*" /label="lpdV CDS" gene complement(2027707..2029131) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /label="lpdV gene" CDS complement(2029152..2030243) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /EC_number="2.7.2.-" /EC_number="2.7.2.7" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain fatty-acid kinase" /protein_id="NP_390287.2" /db_xref="EnsemblGenomes-Gn:BSU24070" /db_xref="EnsemblGenomes-Tr:CAB14338" /db_xref="GOA:P54532" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR011245" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG11724" /db_xref="UniProtKB/Swiss-Prot:P54532" /translation="MKVLHDEKRILTINPGSTSTKIGVFHNERSIFEKTLRHNIEELQ RFDRIIDQYEFRKNHILETLHEQGINISKFDAVCARGGLLRPIEGGTYVVNDEMIEDL KSGYAGQHASNLGGIIAREIADGLNIPSYIVDPVVVDEMSVLAKVSGMPEIERKSIFH ALNQKAVARKAAASLGKRYENMKMIITHMGGGITIGVHDRGRVVDVNNGLHGEGPFSP ERAGTVPAGDLVDLCFSGEYTKEEIMKKLVGTGGLLGYLGTNDAVKVEQMIQGGDEKA RFIYDAMAYQVAKEIGAASAALKGEVEAIVLTGGLAYGKSFVSAIRSYIDWISDVLVY PGENELQSLAQGALRVLQGEEQSKQYRIE*" /label="buk CDS" gene complement(2029152..2030243) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /label="buk gene" CDS complement(2030262..2031356) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /EC_number="1.4.1.8" /EC_number="1.4.1.-" /EC_number="1.4.1.9" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid dehydrogenase" /protein_id="NP_390288.1" /db_xref="EnsemblGenomes-Gn:BSU24080" /db_xref="EnsemblGenomes-Tr:CAB14339" /db_xref="GOA:P54531" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR016211" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11723" /db_xref="UniProtKB/Swiss-Prot:P54531" /translation="MELFKYMEKYDYEQLVFCQDEQSGLKAIIAIHDTTLGPALGGTR MWTYENEEAAIEDALRLARGMTYKNAAAGLNLGGGKTVIIGDPRKDKNEEMFRAFGRY IQGLNGRYITAEDVGTTVEDMDIIHDETDYVTGISPAFGSSGNPSPVTAYGVYRGMKA AAKAAFGTDSLEGKTIAVQGVGNVAYNLCRHLHEEGANLIVTDINKQSVQRAVEDFGA RAVDPDDIYSQDCDIYAPCALGATINDDTIKQLKAKVIAGAANNQLKETRHGDQIHEM GIVYAPDYVINAGGVINVADELYGYNAERALKKVEGIYGNIERVLEISQRDGIPAYLA ADRLAEERIERMRRSRSQFLQNGHSVLSRR*" /label="bcd CDS" gene complement(2030262..2031356) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /label="bcd gene" CDS complement(2031368..2032267) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /EC_number="2.3.1.19" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphate BCFA and butyryl coenzyme A transferase" /protein_id="NP_390289.2" /db_xref="EnsemblGenomes-Gn:BSU24090" /db_xref="EnsemblGenomes-Tr:CAB14340" /db_xref="GOA:P54530" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR012147" /db_xref="InterPro:IPR014079" /db_xref="SubtiList:BG11722" /db_xref="UniProtKB/Swiss-Prot:P54530" /translation="MKLKDLIGKASIHKNKTIAVAHAEDEEVIRAVKLAAEHLSARFL LTGDSKKLNELTSSMQGHQVEIVHANTPEESAKLAVRAVHHKTADVLMKGNVPTSVLL KAVLNRQEGLRSASVLSHVAVFDIPDFDRLMFVTDSAMNIAPSLEELRQILQNAVHVA HAVGNNMPKAAALAAVETVNPKMEATVNAAALAQMYKRGQIKGCIVDGPLALDNAVSQ IAAAQKKISGDVAGNADILLVPTIEAGNILYKSLIYFAKASVAAVITGAKAPIALTSR ADSAENKLYSIALAICASEEYTH*" /label="ptb CDS" gene complement(2031368..2032267) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /label="ptb gene" misc_feature complement(2032303..2032322) /Source="Nicolas_upshift_promotors" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2032308) /Source="Nicolas_upshifts" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2032310..2032391) /Source="Nicolas_S_feature" /locus_tag="new_2504707_2504788_c" /HighExp="Cold, LBGtran, G180, Lbexp, G135, G150, LBGexp, Diami, Oxctl, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S910" CDS complement(2032392..2034470) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_390290.1" /db_xref="EnsemblGenomes-Gn:BSU24100" /db_xref="EnsemblGenomes-Tr:CAB14341" /db_xref="GOA:P54529" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11721" /db_xref="UniProtKB/Swiss-Prot:P54529" /translation="MQKVLIVGAGKRGTALLHILIKTAIIDIIAVVDKDPEAPGLKEA EQYGIAVSSDWKPYIQQKPDIVIHTTGDQAVFDELLQRKHEDTIVMPGKMAYIVFQLM EEKQHLIQMLKEQTYKYDRIFNSTHDGMIFIDINEEIILFNHMAEKMVGKKREEVIGR PIKEVIPSTKMPRILKTRVPEYNQKQLLGDHLQIVTTRLPIIDEGGRLLGALCVFKDI TDAVELAEEVTNLKQVRTMLEAIIQSSDEAISVVDENGIGLLINKAYTKMTGLSEKEV IGKPANTDISEGESMHLKVLETRRPVRGVRMKVGPNEKEVIVNVAPVIVDGILKGSVG VIHDVSEIKMLTAELNRARQIIRTLEAKYTFDDIIGKSEQMLVALEQAKLGAKTPATI LLRGESGTGKELFAHAIHNESDRKYNKFIRVNCAALSENLLESELFGYEDGAFSGAKR GGKKGLFEEANNGSIFLDEIGELTQNMQAKLLRVLQEKEIVRVGGTKAIPVNVRVIAA TNVNIEKAMADGTFREDLYYRINRYPISIPPLRQRLEDIEALSVRLIQKINRDYGRNV KGLSQQALRALSAYHWPGNVRELENVLGRAMIFLNPHMEWIEKDHLPVFELEQKENDT DQGTGFDFPDIEGEKLSVAVEKFEAHLIQQTLEKHHFNRTKTAKALGVSIRNLYYKMD KYGLANEGMQ*" /label="bkdR CDS" gene complement(2032392..2034470) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /label="bkdR gene" promotor_-10 complement(2034530..2034549) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2034547) /Source="Nicolas_upshifts" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2034557..2034564 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2034566..2034569) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2034578..2034597 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2034585 /Source="Nicolas_upshifts" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="upshifts" CDS 2034623..2034859 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390291.1" /db_xref="EnsemblGenomes-Gn:BSU24110" /db_xref="EnsemblGenomes-Tr:CAB14342" /db_xref="GOA:O32015" /db_xref="InterPro:IPR020138" /db_xref="SubtiList:BG13772" /db_xref="UniProtKB/Swiss-Prot:O32015" /translation="MSRLLALLILVIPGAISALGIKLMRDTLFGHTIKPFSALWLQGL SGFIFFAIGLYVLAGFILYRDRKRNQVSPRFRKR*" /label="yqzF CDS" gene 2034623..2034859 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /label="yqzF gene" downshifts 2034850 /Source="Nicolas_upshifts" /id="D1259" /incds=0 /nref=64 /ntot=230 /MaxReadThrough="2.80342" /MaxDrop="5.10794" /score="42.7247617" /energy="-11.9" /TU="NA" /idTUdmin="U1880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2034901..2035806) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /EC_number="4.1.3.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12706720, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12706720, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylisocitrate lyase" /protein_id="NP_390292.1" /db_xref="EnsemblGenomes-Gn:BSU24120" /db_xref="EnsemblGenomes-Tr:CAB14343" /db_xref="GOA:P54528" /db_xref="InterPro:IPR012695" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018523" /db_xref="SubtiList:BG11720" /db_xref="UniProtKB/Swiss-Prot:P54528" /translation="MSWIVNKQSSQEELAGRFRKLMSAPDILQIPGAHDGMAALLAKE AGFSAIYLSGAAYTASRGLPDLGIITSAEIAERAKDLVRAADLPLLVDIDTGFGGVLN AARTAREMLEARVAAVQMEDQQLPKKCGHLNGKQLVPIKEMAQKIKAIKQAAPSLIVV ARTDARAQEGLDAAIKRSEAYIEAGADAIFPEALQAENEFRQFAERIPVPLLANMTEF GKTPYYRADEFEDMGFHMVIYPVTSLRAAAKACERMFGLMKEHGSQKEGLHDMQTRKE LYDTISYYDYEALDKTIAKTVLPDE*" /label="mmgF CDS" gene complement(2034901..2035806) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /label="mmgF gene" downshifts complement(2034904) /Source="Nicolas_upshifts" /id="D1260" /incds=0 /nref=29 /ntot=69 /MaxReadThrough="2.12559" /MaxDrop="5.62" /score="33.814061" /energy="-11.9" /TU="NA" /idTUdmin="U1884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2035824..2037242) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /EC_number="4.2.1.79" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylcitrate dehydratase (promiscuous)" /protein_id="NP_390293.2" /db_xref="EnsemblGenomes-Gn:BSU24130" /db_xref="EnsemblGenomes-Tr:CAB14344" /db_xref="GOA:P45859" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR012705" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11323" /db_xref="UniProtKB/Swiss-Prot:P45859" /translation="MPKTDRVIEEITDYVLEKEITSAEAYTTAGHVLLDTLGCGILAL RYPECTKLLGPIVPGTTVPNGSKVPGTSYVLDPVRAAFNIGCMIRWLDYNDTWLAAEW GHPSDNLGGILAAADYVSRVRLSEGKEPLTVRDVLEMMIKAHEIQGVLALENSLNRVG LDHVLFVKVATTAVAAKLLGGGREEIKNALSNAWIDNAALRTYRHSPNTGSRKSWAAG DATSRGVHLALMSLKGEMGYPTALSAPGWGFQDVLFNKKEIKLARPLDAYVMENVLFK VSYPAEFHAQTAAESAVILHPQVKNRIDEIDRVVIRTHESAIRIIDKKGPLHNPADRD HCLQYITAIGLLFGDITAQHYEAETANDPRIDKLRDKMEVTENKTYTEDYLKPDKRSI SNAVQVHFKDGTSTEMVECEFPLGHRFRREEAVPKLLEKFSDNLKTHFPDKQHKHIYE RCTSYETLQTMRVNEFVDMFCM*" /label="mmgE CDS" gene complement(2035824..2037242) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /label="mmgE gene" misc_feature complement(2036119..2036138) /Source="Nicolas_upshift_promotors" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2036136) /Source="Nicolas_upshifts" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2037257..2038375) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /EC_number="2.3.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional citrate synthase/2-methylcitrate synthase" /protein_id="NP_390294.1" /db_xref="EnsemblGenomes-Gn:BSU24140" /db_xref="EnsemblGenomes-Tr:CAB14345" /db_xref="GOA:P45858" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG11322" /db_xref="UniProtKB/Swiss-Prot:P45858" /translation="MEEKQHYSPGLDGVIAAETHISYLDTQSSQILIRGYDLIELSET KSYLELVHLLLEGRLPEESEMETLERKINSASSLPADHLRLLELLPEDTHPMDGLRTG LSALAGYDRQIDDRSPSANKERAYQLLGKMPALTAASYRIINKKEPILPLQTLSYSAN FLYMMTGKLPSSLEEQIFDRSLVLYSEHEMPNSTFAARVIASTHSDLYGALTGAVASL KGNLHGGANEAVMYLLLEAKTTSDFEQLLQTKLKRKEKIMGFGHRVYMKKMDPRALMM KEALQQLCDKAGDHRLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWMLGIPIPLYTPI FFSARTSGLCAHVIEQHANNRLFRPRVSYMGPRYQTKS*" /label="mmgD CDS" gene complement(2037257..2038375) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /label="mmgD gene" CDS complement(2038409..2039548) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="propionyl-CoA dehydrogenase subunit" /protein_id="NP_390295.2" /db_xref="EnsemblGenomes-Gn:BSU24150" /db_xref="EnsemblGenomes-Tr:CAB14346" /db_xref="GOA:P45857" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="PDB:5LNX" /db_xref="SubtiList:BG11321" /db_xref="UniProtKB/Swiss-Prot:P45857" /translation="MHVTQEQVMMRKMVRDFARKEIAPAAEIMEKTDEFPFQLIKKMG KHGLMGIPVPEQYGGAGADVVSYILAIHEISRISAAVGVILSVHTSVGTNPILYFGNE EQKMKYIPNLASGDHLGAFALTEPHSGSDAGSLRTTAIKKNGKYLLNGSKIFITNGGA ADIYITFALTAPDQGRHGISAFIVEKNTPGFTVGKKERKLGLYGSNTTELIFDNAEVP EANLLGKEGDGFHIAMANLNVGRIGIAAQALGIAEAALEHAVDYAKQRVQFGRPIAAN QGISFKLADMATRAEAARHLVYHAADLHNRGLNCGKEASMAKQFASDAAVKAALDAVQ IYGGYGYMKDYPVERLLRDAKVTQIYEGTNEIQRLIISKYLLGGT*" /label="mmgC CDS" gene complement(2038409..2039548) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /label="mmgC gene" CDS complement(2039576..2040439) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /EC_number="1.1.1.157" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 18461320, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 18461320, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxybutyryl-CoA dehydrogenase" /protein_id="NP_390296.2" /db_xref="EnsemblGenomes-Gn:BSU24160" /db_xref="EnsemblGenomes-Tr:CAB14347" /db_xref="GOA:P45856" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR006180" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR022694" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11320" /db_xref="UniProtKB/Swiss-Prot:P45856" /translation="MEIKQIMVAGAGQMGSGIAQTAADAGFYVRMYDVNPEAAEAGLK RLKKQLARDAEKGKRTETEVKSVINRISISQTLEEAEHADIVIEAIAENMAAKTEMFK TLDRICPPHTILASNTSSLPITEIAAVTNRPQRVIGMHFMNPVPVMKLVEVIRGLATS EETALDVMALAEKMGKTAVEVNDFPGFVSNRVLLPMINEAIYCVYEGVAKPEAIDEVM KLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGDSKYRPCPLLRKYVKAGWLGKKSG RGFYDYEEKTS*" /label="mmgB CDS" gene complement(2039576..2040439) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /label="mmgB gene" CDS complement(2040464..2041645) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /EC_number="2.3.1.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16352833, 18246303, 19016856, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352833, 18246303, 19016856, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="degradative acetoacetyl-CoA thiolase" /protein_id="NP_390297.1" /db_xref="EnsemblGenomes-Gn:BSU24170" /db_xref="EnsemblGenomes-Tr:CAB14348" /db_xref="GOA:P45855" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="PDB:5LP7" /db_xref="SubtiList:BG11319" /db_xref="UniProtKB/Swiss-Prot:P45855" /translation="MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVS GDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMI RAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVH GNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDE AIRRDTSLDQLAKLAPIYASDGSITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATI LGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAFASVVLTCEKIVGFD LEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQV H*" /label="mmgA CDS" gene complement(2040464..2041645) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /label="mmgA gene" downshifts complement(2041225) /Source="Nicolas_upshifts" /id="D1261" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17207" /MaxDrop="2.33167" /score="-0.949614429" /energy="-7.8" /TU="U1884" /idTUdmin="U1885" /TUdmin=550 /isTUend="FALSE" /label="downshifts" misc_feature complement(2041332..2041338) /Source="Nicolas_upshift_promotors" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2041335) /Source="Nicolas_upshifts" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2041559..2041659) /Source="Nicolas_upshift_promotors" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2041599) /Source="Nicolas_upshifts" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2041692..2041710) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2041710) /Source="Nicolas_upshifts" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2041726..2041731) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2041772..2042503) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /EC_number="3.1.4.46" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 14563871, 21966272, 22843846, 24373430, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 14563871, 21966272, 22843846, 24373430, 27780866; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycerophosphodiester phosphodiesterase (exolytic cleavage of individual teichoic acid monomer units)" /protein_id="NP_390298.2" /db_xref="EnsemblGenomes-Gn:BSU24180" /db_xref="EnsemblGenomes-Tr:CAB14349" /db_xref="GOA:P54527" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG11719" /db_xref="UniProtKB/Swiss-Prot:P54527" /translation="MTKIFAHRGASGQFPENTMLAFEKGIEAGADGIELDVQLTKDGR IVVIHDERLNRTTSLKGFVKDTAYDEVKTANAAAGHDQAYSDIKVPLLEDVLSWAVKK DFLINIELKNSVIRYEGMEEKVLEAVKRFNVEDRVILSTFNHDSLALCARLAPHIERA VLTSDVLYQADRYIASIPASGYHPKINSPGVTDEVLKKMRNGLIKVRPYTVNRPEDMK RLIEAGADGMFTDFPEKASALLKNE*" /label="glpQ CDS" gene complement(2041772..2042503) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /label="glpQ gene" downshifts complement(2041779) /Source="Nicolas_upshifts" /id="D1262" /incds=0 /nref=31 /ntot=180 /MaxReadThrough="0.31166" /MaxDrop="4.10202" /score="-0.949614429" /energy="-7.8" /TU="NA" /idTUdmin="U1885" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2042526..2042545) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2042537) /Source="Nicolas_upshifts" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2042560..2042563) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2042582..2043202) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /EC_number="3.5.1.28" /experiment="publication(s) with functional evidences, PMID:22843846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22843846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390299.2" /db_xref="EnsemblGenomes-Gn:BSU24190" /db_xref="EnsemblGenomes-Tr:CAB14350" /db_xref="GOA:P54525" /db_xref="InterPro:IPR002508" /db_xref="SubtiList:BG11717" /db_xref="UniProtKB/Swiss-Prot:P54525" /translation="MRMLWRSLALCGLALTLAPCAQAAEPIEGKTVYIDAGHGGEDSG AVGNGLFEKDINLAVSEHVTDKLKEEGANPVASRSDDHFLTLEERVAKASANQADLFV SIHVNSGVASASGTETYFQSDYEGENSRRLASDIQSQLVSSLQTRDRGVKESDFYVIT YSQMPSVLAELGFITNSSDADKLGSEEYQQKAADAIVNGIDSYYDQ*" /label="yqiI CDS" gene complement(2042582..2043202) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /label="yqiI gene" CDS complement(2043217..2043510) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22843846; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390300.2" /db_xref="EnsemblGenomes-Gn:BSU24200" /db_xref="EnsemblGenomes-Tr:CAB14351" /db_xref="GOA:P40770" /db_xref="SubtiList:BG11030" /db_xref="UniProtKB/Swiss-Prot:P40770" /translation="MKQTVLLLFTALFLSGCSVASADDSVPRFTEEGKYIGSADPHTI AVSLNGEETMIQVPKDKRDECESLPDQTHVLVKYTKKDNGTLQLEDIQLRKNS*" /label="yqiH CDS" gene complement(2043217..2043510) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /label="yqiH gene" promotor_-10 complement(2043530..2043549) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2043536) /Source="Nicolas_upshifts" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2043564..2043571) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2043766..2043773 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2043787..2043806 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2043804..2044009 /Source="Nicolas_S_feature" /locus_tag="new_2516201_2516406" /HighExp="Diami, dia15, dia5, H2O2, Paraq, LBGexp, G180, LBGstat, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99653599999999998" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S911" upshifts 2043804 /Source="Nicolas_upshifts" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2043818..2043970 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513977.1" /translation="MKEVKAMKKFVLLLAAAVITCSIGHQISGGYKGPEKERPKHHSA LKIFSR*" /label="hypothetical protein CDS" gene 2043818..2043970 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /label="gene" promotor_-35 2043978..2043985 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2044000..2044019 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2044011 /Source="Nicolas_upshifts" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2044043..2045161 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-dependent flavin oxidoreductase" /protein_id="NP_390301.1" /db_xref="EnsemblGenomes-Gn:BSU24210" /db_xref="EnsemblGenomes-Tr:CAB14352" /db_xref="GOA:P54524" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11716" /db_xref="UniProtKB/Swiss-Prot:P54524" /translation="MNPKYKPLFEPFTFKSGVTINNRIAVAPMTHYASNEDGTISEAE LDYIIPRSKEMGMVITACANVTPDGKAFPGQPAIHDDSNIPGLKKLAQAIQAQGAKAV VQIHHGGIECPSELVPQQDVVGPSDVFDNGKQIARALTEEEVENIVKAFGEATRRAIE AGFDGVEIHGANGYLIQQFYSPKTNQRTDRWGGSDEKRLAFPLAIVDEVKKAASEHAK GAFLVGYRLSPEEPETPGLTMTETYTLVDALGDKELDYLHISLMDVNSKARRGADPTR TRMDLLNERVGNKVPLIAVGSIHSADDALAVIENGIPLVAMGREILVDPNWTVKVKEG REKQIETVIKGTDKEKYHLPEPLWQAIVNTQGWVPYKD*" /label="yqiG CDS" gene 2044043..2045161 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /label="yqiG gene" downshifts 2045146 /Source="Nicolas_upshifts" /id="D1263" /incds=0 /nref=23 /ntot=181 /MaxReadThrough="1.88324" /MaxDrop="6.67511" /score="30.8551972" /energy="-16.1" /TU="NA" /idTUdmin="U1887" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2045188..2045358) /Source="Nicolas_S_feature" /locus_tag="new_2517585_2517755_c" /HighExp="T0.30H, S6, S8, T1.30H, T1.0H, T-0.40H, S7, Salt, T0.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="1, 0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S912" downshifts complement(2045231) /Source="Nicolas_upshifts" /id="D1264" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="3.46085" /MaxDrop="2.69939" /score="-5.47428449" /energy="-16.1" /TU="U1889" /idTUdmin="U1890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2045342..2045357) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2045358) /Source="Nicolas_upshifts" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2045360..2045488) /Source="Nicolas_S_feature" /locus_tag="new_2517757_2517885_c" /HighExp="S6, S8, S7, S5, BT, M9-stat, B36, G180, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S913" promotor_-35 complement(2045369..2045378) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2045487..2045506) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2045510) /Source="Nicolas_upshifts" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2045520..2045528) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2045620) /Source="Nicolas_upshifts" /id="D1265" /incds=0 /nref=199 /ntot=267 /MaxReadThrough="2.54843" /MaxDrop="4.82417" /score="-1.10791055" /energy="-15.5" /TU="NA" /idTUdmin="U1891" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2045626..2046429) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT" /protein_id="NP_390302.1" /db_xref="EnsemblGenomes-Gn:BSU24220" /db_xref="EnsemblGenomes-Tr:CAB14353" /db_xref="GOA:P06534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR012052" /db_xref="InterPro:IPR014879" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1LQ1" /db_xref="SubtiList:BG10765" /db_xref="UniProtKB/Swiss-Prot:P06534" /translation="MEKIKVCVADDNRELVSLLSEYIEGQEDMEVIGVAYNGQECLSL FKEKDPDVLVLDIIMPHLDGLAVLERLRESDLKKQPNVIMLTAFGQEDVTKKAVDLGA SYFILKPFDMENLVGHIRQVSGNASSVTHRAPSSQSSIIRSSQPEPKKKNLDASITSI IHEIGVPAHIKGYLYLREAISMVYNDIELLGSITKVLYPDIAKKFNTTASRVERAIRH AIEVAWSRGNIDSISSLFGYTVSMTKAKPTNSEFIAMVADKLRLEHKAS*" /label="spo0A CDS" gene complement(2045626..2046429) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /label="spo0A gene" promotor_-10 complement(2046472..2046490) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2046478) /Source="Nicolas_upshifts" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2046480..2046632) /Source="Nicolas_S_feature" /locus_tag="new_2518877_2519029_c" /HighExp="T1.30H, T3.0H, T2.30H, T2.0H, HiTm, Lbtran, T1.0H, T-0.40H, T0.30H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S914" promotor_-35 complement(2046501..2046509) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2046628..2046647) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2046640) /Source="Nicolas_upshifts" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2046659..2046666) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 2046674..2046675 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_005" CDS complement(2046735..2048465) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /function="16.8: Protect" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor for double strand breaks DNA repair and genetic recombination" /protein_id="NP_390304.2" /db_xref="EnsemblGenomes-Gn:BSU24240" /db_xref="EnsemblGenomes-Tr:CAB14355" /db_xref="GOA:P17894" /db_xref="InterPro:IPR004604" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10310" /db_xref="UniProtKB/Swiss-Prot:P17894" /translation="MLAELSIKNFAIIEELTVSFERGLTVLTGETGAGKSIIIDAISL LVGGRGSSEFVRYGEAKAELEGLFLLESGHPVLGVCAEQGIDVSDEMIVMRRDISTSG KSVCRVNGKLVTIASLREIGRLLLDIHGQHDNQLLMEDENHLQLLDKFAGAEVESALK TYQEGYQRYVKLLKKLKQLSESEQEMAHRLDLIQFQLEEIESAKLELNEDEQLQEERQ QISNFEKIYESLQNAYNALRSEQGGLDWVGMASAQLEDISDINEPLKKMSESVSNSYY LLEDATFQMRNMLDELEFDPERLNYIETRLNEIKQLKRKYGATVEDILEYASKIEEEI DQIENRDSHLQSLKKELDSVGKDVAVEAANVSQIRKTWAKKLADEIHRELKSLYMEKS TFDTEFKVRTASRNEEAPLVNGQPVQLTEQGIDLVKFLISTNTGEPLKSLSKVASGGE LSRVMLAIKSIFSSQQDVTSIIFDEVDTGVSGRVAQAIAEKIHKVSIGSQVLCITHLP QVAAMADTHLYIAKELKDGRTTTRVKPLSKQEKVAEIGRMIAGVEVTDLTKRHAKELL KQADQVKTTG*" /label="recN CDS" gene complement(2046735..2048465) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /label="recN gene" downshifts complement(2046750) /Source="Nicolas_upshifts" /id="D1267" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="1.73202" /MaxDrop="6.33427" /score="20.028822" /energy="-12.4" /TU="NA" /idTUdmin="U1895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2048502..2048951) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AhrC(ArgR)-arginine)" /protein_id="NP_390305.1" /db_xref="EnsemblGenomes-Gn:BSU24250" /db_xref="EnsemblGenomes-Tr:CAB14356" /db_xref="GOA:P17893" /db_xref="InterPro:IPR001669" /db_xref="InterPro:IPR020899" /db_xref="InterPro:IPR020900" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR036251" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1F9N" /db_xref="PDB:2P5K" /db_xref="PDB:2P5L" /db_xref="PDB:2P5M" /db_xref="SubtiList:BG10309" /db_xref="UniProtKB/Swiss-Prot:P17893" /translation="MNKGQRHIKIREIITSNEIETQDELVDMLKQDGYKVTQATVSRD IKELHLVKVPTNNGSYKYSLPADQRFNPLSKLKRALMDAFVKIDSASHMIVLKTMPGN AQAIGALMDNLDWDEMMGTICGDDTILIICRTPEDTEGVKNRLLELL*" /label="argR CDS" gene complement(2048502..2048951) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /label="argR gene" S_feature complement(2048952..2049037) /Source="Nicolas_S_feature" /locus_tag="new_2522774_2522859_c" /HighExp="H2O2, G180, G135, G150, Oxctl, Heat, Paraq, C30, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S915" CDS complement(2049049..2049894) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /EC_number="2.1.1.-" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2'-O-ribose RNA methyltransferase" /protein_id="NP_390306.2" /db_xref="EnsemblGenomes-Gn:BSU24260" /db_xref="EnsemblGenomes-Tr:CAB14357" /db_xref="GOA:P19672" /db_xref="InterPro:IPR002877" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR004538" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10308" /db_xref="UniProtKB/Swiss-Prot:P19672" /translation="MTSKKERLDVLLVERGLAETREKAKRAIMAGIVYSNENRLDKPG EKIDRDLPLTVKGNPLRYVSRGGLKLEKALKEFPVSVKDKIMIDIGSSTGGFTDCALQ NGAKQSYAVDVGYNQLAWKLRQDERVVVMERTNFRYATPADFTKGMPEFATIDVSFIS LRLILPVLRTLLVPGSDCMALVKPQFEAGRESVGKKGIVRDPKVHADVLKRMISFSAA EGYICKGLSFSPITGGDGNIEFLLHLHWPGEGQEGQELPEEEIMRVVEEAHKTLKEKK ADVPE*" /label="yqxC CDS" gene complement(2049049..2049894) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /label="yqxC gene" downshifts complement(2049082) /Source="Nicolas_upshifts" /id="D1268" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="5.65358" /MaxDrop="2.6955" /score="4.97422627" /energy="-9.4" /TU="U1895,U1896,U1898" /idTUdmin="U1895" /TUdmin="-2332" /isTUend="FALSE" /label="downshifts" CDS complement(2049891..2051792) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /EC_number="2.2.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12882400, 15292217, 17458547, 23840410, 25212876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-deoxyxylulose-5-phosphate synthase" /protein_id="NP_390307.1" /db_xref="EnsemblGenomes-Gn:BSU24270" /db_xref="EnsemblGenomes-Tr:CAB14358" /db_xref="GOA:P54523" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005477" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11715" /db_xref="UniProtKB/Swiss-Prot:P54523" /translation="MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGP NLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKR SESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIG DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKL AATAERVKDSLKYMLVSGMFFEELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHV ITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDG RIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTF LQRAYDQVVHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKD ENEGQHMVHTALSYDEGPIAMRFPRGNGLGVKMDEQLKTIPIGTWEVLRPGNDAVILT FGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIEEAVLEG GFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMP PKTHKGIGS*" /label="dxs CDS" gene complement(2049891..2051792) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /label="dxs gene" promotor_-35 2051000..2051006 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2051021..2051032 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2051029 /Source="Nicolas_upshifts" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2051793..2051921) /Source="Nicolas_S_feature" /locus_tag="new_2525615_2525743_c" /HighExp="Salt, Heat, dia15, H2O2, HiOs, Cold, T-5.40H, T3.30H, SMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S916" promotor_-10 complement(2051916..2051935) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2051921) /Source="Nicolas_upshifts" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2051950..2051956) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2051967..2052857) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /EC_number="2.5.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755734, 12682299, 17147392, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate synthase" /protein_id="NP_390308.2" /db_xref="EnsemblGenomes-Gn:BSU24280" /db_xref="EnsemblGenomes-Tr:CAB14359" /db_xref="GOA:P54383" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG11714" /db_xref="UniProtKB/Swiss-Prot:P54383" /translation="MTNKLTSFLADRKKTIENQLSVYTEKLDMPDSLKKSMLYSLQAG GKRLRPLIVLAVLNAYGKSEKDGIPVGCAVEMIHTYSLIHDDLPCMDDDDLRRGKPTN HKVFGEATAVLAGDGLLTESFKLITSHVSDEVSAEKRLRLVNELISAAGTEGMVGGQV ADMEAENRQVTLEELESIHERKTAKLLGFCVIAGAILADAPEEDIETLRTFSSHIGIG FQIRDDILDLEGSEEKIGKRVGSDTTNDKSTYPSLLSLEGAKHKLDVHIKEAKRLIGG LSLQKDLLYELCDLIAARDH*" /label="ispA CDS" gene complement(2051967..2052857) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /label="ispA gene" CDS complement(2052847..2053101) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /EC_number="3.1.11.6" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11381137, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (small subunit)" /protein_id="NP_390309.2" /db_xref="EnsemblGenomes-Gn:BSU24290" /db_xref="EnsemblGenomes-Tr:CAB14360" /db_xref="GOA:P54522" /db_xref="InterPro:IPR003761" /db_xref="InterPro:IPR037004" /db_xref="SubtiList:BG11713" /db_xref="UniProtKB/Swiss-Prot:P54522" /translation="MTDVKKNENMTFEEAMKGLESIVSKLEEGDVPLEQAINYFQEGM ALSKMCHEKLQKVEKQMDFILKEDGELAPFSVQEEDEGDK*" /label="xseB CDS" gene complement(2052847..2053101) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /label="xseB gene" CDS complement(2053098..2054444) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /EC_number="3.1.11.6" /function="16.9: Replicate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17182742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (large subunit)" /protein_id="NP_390310.2" /db_xref="EnsemblGenomes-Gn:BSU24300" /db_xref="EnsemblGenomes-Tr:CAB14361" /db_xref="GOA:P54521" /db_xref="InterPro:IPR003753" /db_xref="InterPro:IPR020579" /db_xref="InterPro:IPR025824" /db_xref="SubtiList:BG11712" /db_xref="UniProtKB/Swiss-Prot:P54521" /translation="MGEAAYVTVSALTKYIKRKFDVDPHLENIWIKGELSNVKIHTRG HIYFTLKDENARMQSVMFARQSERLPFKPENGMKVLVRGGISVYEPSGNYQLYAKEMQ PDGVGALYLAYEELKKKLAGEGLFDDRYKKQIPAFPATIGVVTSPTGAAVRDVITTLK RRYPLVKVIVLPALVQGENASRSIVTRIEEANEKEICDVLIVGRGGGSIEELWAFNEE IVARAIFASNIPIISAVGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLIERTKTA EVRMTRAMQQHLGQKKERIQTLQSSYAFRFPKRLYAQKEQQFDLAYQQFQAQLTALLD RKSRQLERETYRLEALHPHEQLKQARTRYQEQTNQLRKNMNIQMKQLHSQFQTVLGKL NALSPLQVMERGYSLAYKEDKLIKSVSQIEEQDRLEIKLKDGVLTCEVLEKRGEEK*" /label="xseA CDS" gene complement(2053098..2054444) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /label="xseA gene" S_feature complement(2054445..2054581) /Source="Nicolas_S_feature" /locus_tag="new_2528267_2528403_c" /HighExp="H2O2, G180, G135, Cold, G150, Paraq, Oxctl, LBGstat, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S917" CDS complement(2054582..2055433) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /EC_number="1.5.1.5" /EC_number="3.5.4.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7061514, 9454603, 12682299, 19171795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase" /protein_id="NP_390311.1" /db_xref="EnsemblGenomes-Gn:BSU24310" /db_xref="EnsemblGenomes-Tr:CAB14362" /db_xref="GOA:P54382" /db_xref="InterPro:IPR000672" /db_xref="InterPro:IPR020630" /db_xref="InterPro:IPR020631" /db_xref="InterPro:IPR020867" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11711" /db_xref="UniProtKB/Swiss-Prot:P54382" /translation="MTATIIDGKETAREKREQLAKEVEELKKQGVTPGLAVILIGDDP ASHSYVRGKKKAAETMGMNFKLDQFDSSLTEAELLSIIDQYNQDPEFHGILVQLPLPD HISEKAVIERISPDKDVDGFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNIDLSGKE VVVVGRSNIVGKPVGQLLLNENATVTYCHSRTENITEHTKKADILVVAVGRANFISAD QIKEGAVVIDVGVNRLENGKLCGDVEFEGAKEKASFITPVPGGVGPMTITMLAHNTVK SAKRTLS*" /label="folD CDS" gene complement(2054582..2055433) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /label="folD gene" CDS complement(2055445..2055840) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16707701, 16946247, 27964882; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription termination factor NusB" /protein_id="NP_390312.2" /db_xref="EnsemblGenomes-Gn:BSU24320" /db_xref="EnsemblGenomes-Tr:CAB14363" /db_xref="GOA:P54520" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR011605" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG11710" /db_xref="UniProtKB/Swiss-Prot:P54520" /translation="MKRRTAREKALQALFQIDVSDIAVNEAIEHALDEEKTDPFFEQL VHGVLEHQDQLDEMISKHLVNWKLDRIANVDRAILRLAAYEMAYAEDIPVNVSMNEAI ELAKRFGDDKATKFVNGVLSNIKSDIEQS*" /label="nusB CDS" gene complement(2055445..2055840) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /label="nusB gene" misc_feature complement(2055883..2055902) /Source="Nicolas_upshift_promotors" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2055902) /Source="Nicolas_upshifts" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2055904..2056066) /Source="Nicolas_S_feature" /locus_tag="new_2529726_2529888_c" /HighExp="G180, G150, Oxctl, Etha, G135, GM 120, dia0, HPh, MG 150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S918" CDS complement(2056104..2056511) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 17114254, 22720735, 28579978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 17114254, 22720735, 28579978; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="alkaline shock protein" /protein_id="NP_390313.2" /db_xref="EnsemblGenomes-Gn:BSU24330" /db_xref="EnsemblGenomes-Tr:CAB14364" /db_xref="InterPro:IPR005531" /db_xref="SubtiList:BG11709" /db_xref="UniProtKB/Swiss-Prot:P54519" /translation="MKDNSLLKMDHEDTHLGKVEIAPEVIEVIAGIAASEVDGVAEMR GNFATGVVERFGKVNHGKGVKVDLADDGITIDVYCVVTFGVSIPKVAASVQENIRQTL LNMTSLSINEINIHIVGIQFDTKAQEVQIDEEM*" /label="yqhY CDS" gene complement(2056104..2056511) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /label="yqhY gene" downshifts complement(2056111) /Source="Nicolas_upshifts" /id="D1269" /incds=0 /nref=6 /ntot=76 /MaxReadThrough="6.4099" /MaxDrop="4.1473" /score="9.44795832" /energy="-9.5" /TU="U1897,U1898" /idTUdmin="U1899" /TUdmin=2409 /isTUend="FALSE" /label="downshifts" CDS complement(2056532..2057884) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /EC_number="6.3.4.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxylase subunit)" /protein_id="NP_390314.2" /db_xref="EnsemblGenomes-Gn:BSU24340" /db_xref="EnsemblGenomes-Tr:CAB14365" /db_xref="GOA:P49787" /db_xref="InterPro:IPR004549" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11384" /db_xref="UniProtKB/Swiss-Prot:P49787" /translation="MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQM ADEAFCIGPKASKDSYLNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEEVNVTF VGPSADAISKMGTKDVARETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKAT AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNY GNTIHLGERDCSIQRRLQKLLEESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEF IYDYNEQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGMELSLKQEDVEFEGW AIECRINAENPSKNFMPSPGEIKMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVIT YGKTRDEAIARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS *" /label="accC CDS" gene complement(2056532..2057884) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /label="accC gene" promotor_-10 complement(2057413..2057432) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-10" upshifts complement(2057420) /Source="Nicolas_upshifts" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="upshifts" promotor_-35 complement(2057447..2057453) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-35" CDS complement(2057896..2058375) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796, 15518551" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796, 15518551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxyl carrier subunit)" /protein_id="NP_390315.1" /db_xref="EnsemblGenomes-Gn:BSU24350" /db_xref="EnsemblGenomes-Tr:CAB14366" /db_xref="GOA:P49786" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001249" /db_xref="InterPro:IPR001882" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG11383" /db_xref="UniProtKB/Swiss-Prot:P49786" /translation="MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVM QQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDENLHKITSPMVGTFYASSSPEAGP YVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE* " /label="accB CDS" gene complement(2057896..2058375) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /label="accB gene" promotor_-10 complement(2058434..2058453) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2058445) /Source="Nicolas_upshifts" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2058467..2058474) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2058531..2059187) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15028710, 15752199, 16959571, 1766372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15028710, 15752199, 16959571, 1766372; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation ratchet engulfment protein" /protein_id="NP_390316.2" /db_xref="EnsemblGenomes-Gn:BSU24360" /db_xref="EnsemblGenomes-Tr:CAB14367" /db_xref="GOA:P49785" /db_xref="InterPro:IPR024232" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11415" /db_xref="UniProtKB/Swiss-Prot:P49785" /translation="MLKKQTVWLLTMLSLVVVLSVYYIMSPESKNAVQMQSEKSASDS GEVATEKAPAKQDTKEKSGTETEKGKEDGTKGTKDSSADKETSAEASEKGTVVTETAD DDLFTTYRLDLEDARSKEREELNAIVSSDDATAKEKSEAYDKMTALSEVEGTEKQLET LIKTQGYEDALVNAEGDKINITVKSDKHSKSKATAIIDLVAKEIKTMKDVAVTFEPSK *" /label="spoIIIAH CDS" gene complement(2058531..2059187) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /label="spoIIIAH gene" downshifts complement(2058538) /Source="Nicolas_upshifts" /id="D1270" /incds=0 /nref=26 /ntot=57 /MaxReadThrough="0.0903599999999987" /MaxDrop="6.40434" /score="21.0450747" /energy="-13" /TU="NA" /idTUdmin="U1899" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" CDS complement(2059188..2059877) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation engulfment assembly protein" /protein_id="NP_390317.2" /db_xref="EnsemblGenomes-Gn:BSU24370" /db_xref="EnsemblGenomes-Tr:CAB14368" /db_xref="GOA:P49784" /db_xref="InterPro:IPR014195" /db_xref="SubtiList:BG11414" /db_xref="UniProtKB/Swiss-Prot:P49784" /translation="MNKNGLWNVLKKQFLPGQTKDGEKPKLTKYHYFLFVFVLGVSFM LVSQLFSSPEKTENAKTITAVSSQHSADSKEKTAEVFKASKSDKPKDSIDDYEKEYEN QLKEILETIIGVDDVSVVVNVDATSLKVYEKNKSNKNTTTEETDKEGGKRSVTDQSSE EEIVMIKNGDKETPVVVQTKKPDIRGVLVVAQGVDNVQIKQTIIEAVTRVLDVPSHRV AVAPKKIKEDS*" /label="spoIIIAG CDS" gene complement(2059188..2059877) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /label="spoIIIAG gene" CDS complement(2059870..2060490) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390318.1" /db_xref="EnsemblGenomes-Gn:BSU24380" /db_xref="EnsemblGenomes-Tr:CAB14369" /db_xref="GOA:P49783" /db_xref="InterPro:IPR014245" /db_xref="SubtiList:BG11413" /db_xref="UniProtKB/Swiss-Prot:P49783" /translation="MSFLTEWLTTIVLFILFAIVIDMLLPSSSMQKYAKMVVSLLLIV VMLTPIFKLFKTDPEVIFEYLTKNGQSESADIKNQINSKKIEIQASQRAYILEEMAVQ LKKKAEERFSHDEYKVGRIKLTAGEKVDSEEDIKTISVYMAPSSEKTVQTVAPVHIDT DHAYVTKEAAEQKEAKQIQTQLADIWEIGSEKITVHMEGGESVGNE*" /label="spoIIIAF CDS" gene complement(2059870..2060490) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /label="spoIIIAF gene" promotor_-10 complement(2060196..2060214) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2060214) /Source="Nicolas_upshifts" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2060230..2060235) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2060504..2061703) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390319.2" /db_xref="EnsemblGenomes-Gn:BSU24390" /db_xref="EnsemblGenomes-Tr:CAB14370" /db_xref="GOA:P49782" /db_xref="InterPro:IPR014194" /db_xref="SubtiList:BG11412" /db_xref="UniProtKB/Swiss-Prot:P49782" /translation="MKRFQWVLLLAVLIIAGRAEIVQAAGNAEQTEDHAETAEQLAER TAASLETDKIGEFWNDIMTEYGGLLPESQKGSLMEFINGDKSFSPQEWLKALFSYLFH EVLANGKLLGTLILLTIFCVILQLLQNAFQQSTVSKVAYSIVYMVLIILALNSFHVAI NYATEAIQTMTSFILALIPLLLALLASSGGAVSAAFFHPVILFLMNTSGLLIQNIVMP LIFLSAILSIVSTMTEQYKVTQLANLLRNIAIGALAVFLTIFLGVISVQGASAAVTDG ITLRTAKFITGNFIPVLGRMFTDATDTVISASLLLKNTVGILGVAILICIAAFPAIKV LSLAFIYKLAAAILQPLGGGPVITCLDVISKSVIYIFAALAIVSLMFFLSLTVIITAG NLTMMMK*" /label="spoIIIAE CDS" gene complement(2060504..2061703) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /label="spoIIIAE gene" CDS complement(2061722..2062123) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390320.1" /db_xref="EnsemblGenomes-Gn:BSU24400" /db_xref="EnsemblGenomes-Tr:CAB14371" /db_xref="GOA:P49781" /db_xref="InterPro:IPR014211" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11411" /db_xref="UniProtKB/Swiss-Prot:P49781" /translation="MQIDIVQIVGLGLIATFLSLIVKEQKPTFAFLIVVFAGCAIFLY LVDQIYDIIRMIEKIAINANVNMVYVETILKIIGIAYIAEFGAQLTKDAGQGAIASKI ELAGKILILVMAVPILTVIIETILGLIPSMS*" /label="spoIIIAD CDS" gene complement(2061722..2062123) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /label="spoIIIAD gene" CDS complement(2062130..2062336) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390321.1" /db_xref="EnsemblGenomes-Gn:BSU24410" /db_xref="EnsemblGenomes-Tr:CAB14372" /db_xref="GOA:P49780" /db_xref="InterPro:IPR009570" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11410" /db_xref="UniProtKB/Swiss-Prot:P49780" /translation="MGVDVNVIFQIAGVGIVVAFLHTILDQMGKKEYAQWVTLLGFIY ILFMVATIVDDLFKKIKAVFLFQG*" /label="spoIIIAC CDS" gene complement(2062130..2062336) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /label="spoIIIAC gene" CDS complement(2062359..2062874) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390322.1" /db_xref="EnsemblGenomes-Gn:BSU24420" /db_xref="EnsemblGenomes-Tr:CAB14373" /db_xref="GOA:Q01368" /db_xref="InterPro:IPR014198" /db_xref="SubtiList:BG10541" /db_xref="UniProtKB/Swiss-Prot:Q01368" /translation="MLKLLGAVFIVVATTWTGFEMAKIYTERPRQIRQLRAALQSLEA EIMYGHTPLHTASQQIAKQLAQPVSTLFSAFSDQLDKGSDSAKTAWEQSLKKVWDTLS LKKSEYEVLKQFGETLGIHDRISQQKHIKLALTHLEASEADAEQAQAKNEKMIKSLGF LAGLLLILLLM*" /label="spoIIIAB CDS" gene complement(2062359..2062874) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /label="spoIIIAB gene" CDS complement(2062868..2063791) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATP-binding stage III sporulation protein" /protein_id="NP_390323.1" /db_xref="EnsemblGenomes-Gn:BSU24430" /db_xref="EnsemblGenomes-Tr:CAB14374" /db_xref="GOA:Q01367" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR014217" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10540" /db_xref="UniProtKB/Swiss-Prot:Q01367" /translation="MNEIAEVLPESMKNALSEIPEQQWLEIEEVRIRINRPVELIRRG QPVYLSYAGTAEDAHLILSRLSNYSMYTLEEELKKGYVTIRGGHRVGLAGRVITENGG VKGLRDIASFNIRIARQKLGIAEPLLPYLYQNSWLNTLIIGPPQTGKTTLLRDLARLS STGKKNMLPVKTGIVDERSEIAGCLRGIPQHQFGQRIDVLDACPKAEGLMMMIRSMSP EVMIVDEIGRMEDTDALLEALHAGVSVIVSAHGWSISDLMKRPSLKRLWEERAFDRYL ELSRAKGPGTVSQIYDKDGNVLSRTTGVKTC*" /label="spoIIIAA CDS" gene complement(2062868..2063791) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /label="spoIIIAA gene" S_feature complement(2063792..2063866) /Source="Nicolas_S_feature" /locus_tag="new_2537614_2537688_c" /HighExp="S3, LoTm, S4, T5.0H, M9-stat, S5, BT, S7, S6, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S919" CDS complement(2063867..2064148) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390324.1" /db_xref="EnsemblGenomes-Gn:BSU24440" /db_xref="EnsemblGenomes-Tr:CAB14375" /db_xref="GOA:P49779" /db_xref="InterPro:IPR020390" /db_xref="SubtiList:BG11459" /db_xref="UniProtKB/Swiss-Prot:P49779" /translation="MKFLLGNINSTVLTMAGLRVLSSMIELTAAIVMLVTNDVRKAVV VNSILAIVGPLIFIITMTVGIYQIAGQLSYAKLILIFTGVVLILAGVHK*" /label="yqhV CDS" gene complement(2063867..2064148) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /label="yqhV gene" promotor_-10 complement(2064168..2064186) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-10" upshifts complement(2064191) /Source="Nicolas_upshifts" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="upshifts" promotor_-35 complement(2064202..2064207) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-35" CDS complement(2064293..2064850) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor P" /protein_id="NP_390325.2" /db_xref="EnsemblGenomes-Gn:BSU24450" /db_xref="EnsemblGenomes-Tr:CAB14376" /db_xref="GOA:P49778" /db_xref="InterPro:IPR001059" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR011768" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013185" /db_xref="InterPro:IPR013852" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015365" /db_xref="InterPro:IPR020599" /db_xref="SubtiList:BG11460" /db_xref="UniProtKB/Swiss-Prot:P49778" /translation="MISVNDFRTGLTIEVDGGIWRVVDFQHVKPGKGAAFVRSKLRNL RTGAIQEKTFRAGEKVAKAQIETKTMQYLYANGDQHVFMDTSSYEQLELSATQIEEEL KYLLENMSVHIMMYQDETLGIELPNTVELKVVETEPGIKGDTASGGTKPAKTETGLVV NVPFFVNEGDTLVVNTSDGSYVSRA*" /label="efp CDS" gene complement(2064293..2064850) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /label="efp gene" downshifts complement(2064305) /Source="Nicolas_upshifts" /id="D1271" /incds=0 /nref=256 /ntot=266 /MaxReadThrough="0.83852" /MaxDrop="7.73118" /score="27.4193827" /energy="-13.5" /TU="NA" /idTUdmin="U1901" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2064875..2065936) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /EC_number="3.4.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23144141, 26735940, 27002156" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23144141, 26735940, 27002156; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase (Met-Xaa and Xaa-Pro, Xaa-Pro-Xaa)" /protein_id="NP_390326.1" /db_xref="EnsemblGenomes-Gn:BSU24460" /db_xref="EnsemblGenomes-Tr:CAB14377" /db_xref="GOA:P54518" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG11708" /db_xref="UniProtKB/Swiss-Prot:P54518" /translation="MKLEKLRNLFGQLGIDGMLITSNTNVRYMTGFTGSAGLAVISGD KAAFITDFRYTEQAKVQVKGFEIIEHGGSLIQTTADTVESFGIKRLGFEQNSMTYGTY ASYSAVISDAELVPVAESVEKLRLIKSSEEIKILEEAAKIADDAFRHILTFMKPGISE IAVANELEFYMRSQGADSSSFDMIVASGLRSSLPHGVASDKLIESGDLVTLDFGAYYK GYCSDITRTVAVGQPSDQLKEIYQVVFDAQALGVAHIKPGMTGKEADALTRDHIAAKG YGDYFGHSTGHGLGMEVHESPGLSVRSSAILEPGMVVTVEPGIYIPETGGVRIEDDIV ITENGNRTITHSPKELIIL*" /label="papA CDS" gene complement(2064875..2065936) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /label="papA gene" CDS complement(2065933..2066379) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10870960, 19099550; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase, type II" /protein_id="NP_390327.1" /db_xref="EnsemblGenomes-Gn:BSU24470" /db_xref="EnsemblGenomes-Tr:CAB14378" /db_xref="GOA:P54517" /db_xref="InterPro:IPR001874" /db_xref="InterPro:IPR018509" /db_xref="InterPro:IPR036441" /db_xref="PDB:1GQO" /db_xref="SubtiList:BG11707" /db_xref="UniProtKB/Swiss-Prot:P54517" /translation="MPHFLILNGPNVNRLGSREPEVFGRQTLTDIETDLFQFAEALHI QLTFFQSNHEGDLIDAIHEAEEQYSGIVLNPGALSHYSYAIRDAVSSISLPVVEVHLS NLYAREEFRHQSVIAPVAKGQIVGLGAEGYKLAVRYLLSQQGGESR*" /label="yqhS CDS" gene complement(2065933..2066379) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /label="yqhS gene" promotor_-10 complement(2066428..2066447) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2066444) /Source="Nicolas_upshifts" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2066460..2066467) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2066466..2067002) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390328.1" /db_xref="EnsemblGenomes-Gn:BSU24480" /db_xref="EnsemblGenomes-Tr:CAB14379" /db_xref="GOA:P54516" /db_xref="InterPro:IPR024563" /db_xref="SubtiList:BG11706" /db_xref="UniProtKB/Swiss-Prot:P54516" /translation="MMTSEKDTEQNEELNEKQKPPVSMAGRVAATGFCGGVLWSFVAY IAYLFHFSEISPNMILQPFVLGEWKKHGLGTVISIILIGVISIGAAFLYFLLLKRLKT MWPGILYGLVLWLLVFFVFNPIFPDVRTVTELTSDTIITTICIYLLYGLFVGYSISFE YNELNSEKLARALGMHRE*" /label="yqhR CDS" gene complement(2066466..2067002) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /label="yqhR gene" promotor_-10 complement(2067015..2067026) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-10" upshifts complement(2067024) /Source="Nicolas_upshifts" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="upshifts" promotor_-35 complement(2067040..2067046) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-35" promotor_-35 2067072..2067078 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2067091 /Source="Nicolas_upshifts" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2067093..2067111 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2067148..2067151 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2067166..2067185 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2067177 /Source="Nicolas_upshifts" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" CDS 2067229..2068185 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390329.2" /db_xref="EnsemblGenomes-Gn:BSU24490" /db_xref="EnsemblGenomes-Tr:CAB14380" /db_xref="GOA:P54515" /db_xref="InterPro:IPR010787" /db_xref="SubtiList:BG11705" /db_xref="UniProtKB/Swiss-Prot:P54515" /translation="MSKHKVPPAYGGQAVVEGVMFGGKHHYVTAIRRTDGSIDFFKLP RKHNPKLNIVKKIPFLRGIAAIIEASANGTKHLNFSSERYGLDPSEDETLEQEEKKSS GLSMYLSLAVIGVLSFLFSKFVFTLVPVFLAELTRPIFSLNTAQIAIESLFKLILLLG YIYFLSMTPLIKRVFQYHGAEHKVINCYEQNLPITVENVQNQSRLHYRCGSSFILFTI IVGMFVYLLVPTDPLWLRVIDRVALIPVVLGISFEVLQLTNKVRDIPGLKLLGYPGLW LQLLTTKEPKDEQVEVAIESFNELLRLEALSEQNQKPSHNVI*" /label="yqhQ CDS" gene 2067229..2068185 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /label="yqhQ gene" CDS 2068225..2068620 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390330.1" /db_xref="EnsemblGenomes-Gn:BSU24500" /db_xref="EnsemblGenomes-Tr:CAB14381" /db_xref="GOA:P54514" /db_xref="SubtiList:BG11704" /db_xref="UniProtKB/Swiss-Prot:P54514" /translation="MNHRVQPIIAVLIALGAFGFLYVLVTNPGEMAKMAVTVIVAGII IYFIVKYVMNRNAGSEGAAFKKAAKQSRRRMKEQKAKHRAGHKGRVSHLRSVPSASKP KPMILKKKSQTQLTVIEGKKNKKKNRALF*" /label="yqhP CDS" gene 2068225..2068620 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /label="yqhP gene" promotor_no_box 2068503..2068603 /Source="Nicolas_upshift_promotors" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2068563 /Source="Nicolas_upshifts" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2068606 /Source="Nicolas_upshifts" /id="D1272" /incds=0 /nref=116 /ntot=283 /MaxReadThrough="2.23161" /MaxDrop="5.94415" /score="29.0609078" /energy="-8" /TU="NA" /idTUdmin="U1903" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2068617..2069492) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipase / acyl esterase" /protein_id="NP_390331.1" /db_xref="EnsemblGenomes-Gn:BSU24510" /db_xref="EnsemblGenomes-Tr:CAB14382" /db_xref="GOA:P54513" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG11703" /db_xref="UniProtKB/Swiss-Prot:P54513" /translation="MYIDGVFSGGGVKGIALAGAYEVLEEKGFRFKRVAGTSAGAIIA AFIASGYTSKEIHALIEEVDGEKLLDQRYSFLPLKMLQWVSIYWRLGLYKGDTIEKWI ADLLRAKGIRVFGDLQKGSLRLIASDLTNGTMIVLPDDLARYGLNPDMFPVARAVRMS CSIPYFFEPIKLKTDTGTATVVDGGVLSNFPIWLFSKERKRPVIGVTLAPRERERPKK NIRNAFELFGALFETMKDAHDARHIASRYEQNIIFLPVDDVMATDFHLTQQKKLALIE LGKRRTELFLKQWTY*" /label="yqhO CDS" gene complement(2068617..2069492) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /label="yqhO gene" promotor_-10 complement(2069519..2069537) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2069536) /Source="Nicolas_upshifts" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2069553..2069558) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2069618..2070046) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+)" /protein_id="NP_390332.2" /db_xref="EnsemblGenomes-Gn:BSU24520" /db_xref="EnsemblGenomes-Tr:CAB14383" /db_xref="GOA:P54512" /db_xref="InterPro:IPR001367" /db_xref="InterPro:IPR022687" /db_xref="InterPro:IPR022689" /db_xref="InterPro:IPR022897" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036421" /db_xref="PDB:1ON1" /db_xref="PDB:1ON2" /db_xref="PDB:2EV0" /db_xref="PDB:2EV5" /db_xref="PDB:2EV6" /db_xref="PDB:2F5C" /db_xref="PDB:2F5D" /db_xref="PDB:2F5E" /db_xref="PDB:2F5F" /db_xref="PDB:2HYF" /db_xref="PDB:2HYG" /db_xref="PDB:3R60" /db_xref="PDB:3R61" /db_xref="PDB:4HV5" /db_xref="PDB:4HV6" /db_xref="PDB:4HX4" /db_xref="PDB:4HX7" /db_xref="PDB:4HX8" /db_xref="SubtiList:BG11702" /db_xref="UniProtKB/Swiss-Prot:P54512" /translation="MTTPSMEDYIEQIYMLIEEKGYARVSDIAEALAVHPSSVTKMVQ KLDKDEYLIYEKYRGLVLTSKGKKIGKRLVYRHELLEQFLRIIGVDEEKIYNDVEGIE HHLSWNSIDRIGDLVQYFEEDDARKKDLKSIQKKTEHHNQ*" /label="mntR CDS" gene complement(2069618..2070046) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /label="mntR gene" downshifts complement(2069645) /Source="Nicolas_upshifts" /id="D1273" /incds=0 /nref=322 /ntot=333 /MaxReadThrough="2.568" /MaxDrop="7.28707" /score="15.888362" /energy="-12" /TU="NA" /idTUdmin="U1908" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2070081..2070100) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2070089) /Source="Nicolas_upshifts" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2070116..2070120) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2070146..2070982) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /EC_number="2.3.1.181" /function="3: Fatty acid and phospholipid metabolism" /experiment="publication(s) with functional evidences, PMID:20882995, 21338420, 21338421, 23960015" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20882995, 21338420, 21338421, 23960015; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein octanoyltransferase" /protein_id="NP_390333.1" /db_xref="EnsemblGenomes-Gn:BSU24530" /db_xref="EnsemblGenomes-Tr:CAB14384" /db_xref="GOA:P54511" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024898" /db_xref="SubtiList:BG11701" /db_xref="UniProtKB/Swiss-Prot:P54511" /translation="MQKETWRFIDSGNASPAFNMALDEALLYWHSEKKIPPVIRFYGW NPATLSVGYFQNIKKEINFEAVHKYNLGFVRRPTGGRGVLHDQELTYSVIVSEEHPEM PATVTEAYRVISEGILQGFRNLGLDAYFAIPRTEKEKESLKNPRSSVCFDAPSWYELV VEGRKVAGSAQTRQKGVILQHGSILLDLDEDKLFDLFLYPSERVRERMQRNFKNKAVA INELIEKRVTMDEARKAFKEGFETGLNIHLEPYELSQEELDFVHHLAETKYASDEWNY KR*" /label="lipM CDS" gene complement(2070146..2070982) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /label="lipM gene" promotor_-10 complement(2071006..2071025) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2071017) /Source="Nicolas_upshifts" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2071019..2071563) /Source="Nicolas_S_feature" /locus_tag="new_2544841_2545385_c" /HighExp="Lbstat, LPhT, HiOs, M0t90, S1, M40t90, Sw, S0, B36, BC" /AntisenseName="yqhL" /AntisenseCor="-0.136624541005539" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S920" promotor_-35 complement(2071039..2071046) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2071063..2071068 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2071082..2071101 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2071082 /Source="Nicolas_upshifts" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="upshifts" S_feature 2071093..2071172 /Source="Nicolas_S_feature" /locus_tag="new_2544915_2544994" /HighExp="dia15, H2O2, dia5, Diami, MG-0.2, G180, UNK1, LBGexp, Heat, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S921" CDS 2071173..2071553 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11092948; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390334.2" /db_xref="EnsemblGenomes-Gn:BSU24540" /db_xref="EnsemblGenomes-Tr:CAB14385" /db_xref="GOA:P54510" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11700" /db_xref="UniProtKB/Swiss-Prot:P54510" /translation="MSNMIVLIIFAAFIIYMIASYVYQQRIMKTLTEEEFRAGYRKAQ LIDVREPNEFEGGHILGARNIPLSQLKQRKNEIRTDKPVYLYCQNSVRSGRAAQTLRK NGCTEIYNLKGGFKKWGGKIKAKK*" /label="yqhL CDS" gene 2071173..2071553 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /label="yqhL gene" downshifts 2071489 /Source="Nicolas_upshifts" /id="D1274" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17088" /MaxDrop="3.92673" /score="27.1863605" /energy="-12" /TU="U1909" /idTUdmin="U1909" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2071533 /Source="Nicolas_upshifts" /id="D1275" /incds=0 /nref=213 /ntot=249 /MaxReadThrough="2.26861" /MaxDrop="6.03848" /score="27.1863605" /energy="-12" /TU="NA" /idTUdmin="U1909" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2071588..2073054) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8181752, 20011599, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8181752, 20011599, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 2) (glycine cleavage system protein P)" /protein_id="NP_390335.1" /db_xref="EnsemblGenomes-Gn:BSU24550" /db_xref="EnsemblGenomes-Tr:CAB14386" /db_xref="GOA:P54377" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023012" /db_xref="SubtiList:BG11511" /db_xref="UniProtKB/Swiss-Prot:P54377" /translation="MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDE DAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFAAIH PLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD FKRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTN PNTLGLFEEQITEMAEIVHQAGGKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFT GPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHAIGRVKPYYGNFGIN VRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKK LGVRTLDIAKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKE AEENPELVQEAPHTTIVKRMDETKAARHPVLRYEAEER*" /label="gcvPB CDS" gene complement(2071588..2073054) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /label="gcvPB gene" downshifts complement(2071608) /Source="Nicolas_upshifts" /id="D1276" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="3.45831" /MaxDrop="4.3142" /score="0.884126414" /energy="-12" /TU="U1911" /idTUdmin="U1911" /TUdmin="-1517" /isTUend="FALSE" /label="downshifts" CDS complement(2073047..2074393) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8181752, 20011599, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 1) (glycine cleavage system protein P)" /protein_id="NP_390336.2" /db_xref="EnsemblGenomes-Gn:BSU24560" /db_xref="EnsemblGenomes-Tr:CAB14387" /db_xref="GOA:P54376" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023010" /db_xref="SubtiList:BG11510" /db_xref="UniProtKB/Swiss-Prot:P54376" /translation="MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQI KKAKSETELTRELTKLASKNRDTVQYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTP YQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVV SKTVHPESREVLKTYAKGQYIDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFG RIEPLKDIEPIAHQGKSMFIVSANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGP HCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIRRDKATSNICSNQAL NALAASVAMTALGKNGVKDIARQNLLKANYAKQEAKKAGLTVMFDGPMFNEFVIKLDE PVRAVNKRLLAKGMIGGYDLGLTYPELDCHMLIAVTELRTKEEIDALIQELGDRHE*" /label="gcvPA CDS" gene complement(2073047..2074393) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /label="gcvPA gene" CDS complement(2074423..2075511) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /EC_number="2.1.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8219277, 15472076, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8219277, 15472076, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminomethyltransferase (glycine cleavage system protein T)" /protein_id="NP_390337.2" /db_xref="EnsemblGenomes-Gn:BSU24570" /db_xref="EnsemblGenomes-Tr:CAB14388" /db_xref="GOA:P54378" /db_xref="InterPro:IPR006222" /db_xref="InterPro:IPR006223" /db_xref="InterPro:IPR013977" /db_xref="InterPro:IPR022903" /db_xref="InterPro:IPR028896" /db_xref="InterPro:IPR029043" /db_xref="PDB:1YX2" /db_xref="SubtiList:BG11509" /db_xref="UniProtKB/Swiss-Prot:P54378" /translation="MLKRTPLFDLYKEYGGKTIDFGGWELPVQFSSIKKEHEAVRTAA GLFDVSHMGEVEVSGNDSLSFLQRLMTNDVSALTPGRAQYTAMCYPDGGTVDDLLIYQ KGENRYLLVINASNIDKDLAWMKEHAAGDVQIDNQSDQIALLAVQGPKAEAILKNLTD ADVSALKPFAFIDEADISGRKALISRTGYTGEDGYEIYCRSDDAMHIWKKIIDAGDAY GLIPCGLGARDTLRFEAKLPLYGQELTRDITPIEAGIGFAVKHKKESDFFGKSVLSEQ KENGAKRKLVGLEMIEKGIPRHGYEVFQNGKSVGKVTTGTQSPTLGKNVGLALIDSET SEIGTVVDVEIRKKLVKAKVVKTPFYKR*" /label="gcvT CDS" gene complement(2074423..2075511) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /label="gcvT gene" misc_RNA complement(2075585..2075784) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /product="dual aptamer glycine riboswitch" /experiment="publication(s) with functional evidences, PMID:15472076, 21439473, 23249744, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15472076, 21439473, 23249744, 23721735, 29089431; Product type n: RNA" /label="swgA RNA" gene complement(2075585..2075784) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /label="swgA gene" downshifts complement(2075635) /Source="Nicolas_upshifts" /id="D1277" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="6.79606" /MaxDrop="3.0322" /score="21.5485037" /energy="-20.2" /TU="U1911" /idTUdmin="U1915" /TUdmin=3630 /isTUend="FALSE" /label="downshifts" S_feature complement(2075785..2075855) /Source="Nicolas_S_feature" /locus_tag="new_2549607_2549677_c" /HighExp="B60, S8, S6, B36, S7, M9-stat, Sw, T3.0H, HiOs, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S922" promotor_-35 2075788..2075793 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2075809..2075827 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2075813 /Source="Nicolas_upshifts" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2075823..2075952 /Source="Nicolas_S_feature" /locus_tag="new_2549645_2549774" /HighExp="S4, S8, S7, S3, S5, S6, LoTm, T5.0H, T4.0H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.83" /TUlongSig="NA" /TUlongPSig="NA" /label="S923" promotor_-10 complement(2075841..2075860) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-10" upshifts complement(2075855) /Source="Nicolas_upshifts" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="upshifts" promotor_-35 complement(2075874..2075881) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-35" CDS 2075953..2077626 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /EC_number="3.6.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA polymerase-associated helicase protein" /protein_id="NP_390338.1" /db_xref="EnsemblGenomes-Gn:BSU24580" /db_xref="EnsemblGenomes-Tr:CAB14389" /db_xref="GOA:P54509" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11699" /db_xref="UniProtKB/Swiss-Prot:P54509" /translation="MNTEMIYDAKWPEEFAERLKNDGPWANWELYKLSAEIQKTLAIP EFEGLRAPLYLPSFTPLPHQLEVAQKVVEKMNGKAILADEVGLGKTVEAGLILKEYMI RGLAKKILILVPASLVSQWVKELQEKFLIPAVEQKKSYVWEQCDIVVSSIDTAKRSPH REIVLSIPYDLVIIDEAHKLKNSKTKNYEFVRNLVKKYCLLLTATPIQNRIEEIFNLV SLLKPGHLGSQNHFQEEFAKKKSSLEAHEHLKDLVNKVMIRNRRHDTGLNWKQRHVET VPIQFSPSEQALYDEISRLKDSINKPASMFSIMTLQRECCSSREAVYMTLKKMLDQKE KQAPAIDEDTISVLIDRINQVTQNSKALQVVDLIKKIDDKVIIFTEYRATQIYLQWFL QQNGISSVPFRGGFKRGKKDWMKDLFRGKIQVLIATEAGGEGINLQFCNHMINYDLPW NPMRLEQRIGRIHRLGQERDVHIYNMATKHTVEEHILKLLYEKIHLFEKVVGELDDIL TKIQVNNFEEHLHDILYHSATEEEMKIKMDNLTSFLSYKKQLPAEKRGS*" /label="yqhH CDS" gene 2075953..2077626 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /label="yqhH gene" CDS 2077647..2078441 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390339.1" /db_xref="EnsemblGenomes-Gn:BSU24590" /db_xref="EnsemblGenomes-Tr:CAB14390" /db_xref="InterPro:IPR024562" /db_xref="SubtiList:BG11698" /db_xref="UniProtKB/Swiss-Prot:P54508" /translation="MRQQEVHDFLLRFFQANSCQIVDQGLGYMTVQLTVEMDKQIMNR PFYWHWREKTGGDPNPMKITFITDKENAPKDLDGEFIYFGAPRLFQIFKAVKQNGRFT RMYEKIESAGAKVPLQPWLGINVTISYQSDMKKDKLLSLGLHLVSGTIIEDFQSKLTQ FSLTSQICDYCFTISPMIKPESGLKRMENYISKSAMQEPSDWAEQAVNRWKNDMTLLD KFYEHIEEKPEEYHLEKQALKTLYQPKISVEIENGGLFYLQNNISS*" /label="yqhG CDS" gene 2077647..2078441 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /label="yqhG gene" misc_feature 2077977..2077978 /Source="Nicolas_upshift_promotors" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2077983 /Source="Nicolas_upshifts" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="upshifts" promotor_-35 2078465..2078468 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2078484..2078503 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2078485..2078623 /Source="Nicolas_S_feature" /locus_tag="new_2552307_2552445" /HighExp="LoTm, S4, S5, T5.0H, M9-stat, S3, B60, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.843, 0.83" /TUlongSig="SigA" /TUlongPSig="0.541" /label="S924" upshifts 2078485 /Source="Nicolas_upshifts" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2078624..2078797 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antagonist of SinR" /protein_id="NP_390340.1" /db_xref="EnsemblGenomes-Gn:BSU24600" /db_xref="EnsemblGenomes-Tr:CAB14391" /db_xref="GOA:P23308" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="SubtiList:BG10753" /db_xref="UniProtKB/Swiss-Prot:P23308" /translation="MKNAKQEHFELDQEWVELMVEAKEANISPEEIRKYLLLNKKSAH PGPAARSHTVNPF*" /label="sinI CDS" gene 2078624..2078797 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /label="sinI gene" promotor_-35 2078782..2078786 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2078799..2078818 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2078799 /Source="Nicolas_upshifts" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2078831..2079166 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator of biofilm formation" /protein_id="NP_390341.1" /db_xref="EnsemblGenomes-Gn:BSU24610" /db_xref="EnsemblGenomes-Tr:CAB14392" /db_xref="GOA:P06533" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="PDB:2YAL" /db_xref="PDB:3QQ6" /db_xref="PDB:3ZKC" /db_xref="SubtiList:BG10754" /db_xref="UniProtKB/Swiss-Prot:P06533" /translation="MIGQRIKQYRKEKGYSLSELAEKAGVAKSYLSSIERNLQTNPSI QFLEKVSAVLDVSVHTLLDEKHETEYDGQLDSEWEKLVRDAMTSGVSKKQFREFLDYQ KWRKSQKEE*" /label="sinR CDS" gene 2078831..2079166 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /label="sinR gene" downshifts 2079143 /Source="Nicolas_upshifts" /id="D1278" /incds=0 /nref=21 /ntot=181 /MaxReadThrough="4.7611" /MaxDrop="6.41889" /score="2.30357781" /energy="-20" /TU="U1913,U1914" /idTUdmin="U1910" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts 2079233 /Source="Nicolas_upshifts" /id="D1279" /incds=0 /nref=1 /ntot=85 /MaxReadThrough="2.4376" /MaxDrop="4.25363" /score="58.1462301" /energy="-26.8" /TU="NA" /idTUdmin="U1913" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts complement(2079265) /Source="Nicolas_upshifts" /id="D1280" /incds=0 /nref=144 /ntot=227 /MaxReadThrough="4.33009" /MaxDrop="8.70948" /score="10.0483516" /energy="-20" /TU="NA" /idTUdmin="U1915" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(2079282,2079289) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs27" N_region 2079283..2079288 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs27" promotor_-35 2079358..2079364 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2079365 /Source="Nicolas_upshifts" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2079378..2079389 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2079408..2079734 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390345.1" /db_xref="EnsemblGenomes-Gn:BSU24650" /db_xref="EnsemblGenomes-Tr:CAB14396" /db_xref="InterPro:IPR024987" /db_xref="PDB:2LYX" /db_xref="SubtiList:BG13773" /db_xref="UniProtKB/Swiss-Prot:O32019" /translation="MMIKQCVICLSLLVFGTTAAHAEETPLVTARHMSKWEEIAVKEA KKRYPLAQVLFKQKVWDRKRKDEAVKQYHLTLREGSKEFGVFVTISFDPYSQKVNKIA ILEEYQ*" /label="yqzG CDS" gene 2079408..2079734 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /label="yqzG gene" S_feature complement(2079551..2079775) /Source="Nicolas_S_feature" /locus_tag="new_2555662_2555886_c" /HighExp="GM 150, G/S, C30, T-4.40H, S8, T-3.40H, Pyr, S7, S2, C90" /AntisenseName="yqzG" /AntisenseCor="0.536702817178903" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.549, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S925" downshifts complement(2079594) /Source="Nicolas_upshifts" /id="D1281" /incds=1 /nref=92 /ntot=160 /MaxReadThrough="2.23218" /MaxDrop="5.56661" /score="31.27773" /energy="-10.2" /TU="NA" /idTUdmin="U1918" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2079716 /Source="Nicolas_upshifts" /id="D1282" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="2.14107" /MaxDrop="4.98052" /score="-9.62570043" /energy="-15.1" /TU="NA" /idTUdmin="U1917" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2079776..2079955) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="factor involved in sporulation" /protein_id="NP_390346.2" /db_xref="EnsemblGenomes-Gn:BSU24660" /db_xref="EnsemblGenomes-Tr:CAB14397" /db_xref="InterPro:IPR025622" /db_xref="SubtiList:BG13771" /db_xref="UniProtKB/Swiss-Prot:O32020" /translation="MKTNDYVKYMTQQFVKYIDTPRDERKERKEVRKETKTPVSQQWF GILPYGFRLWLKRKK*" /label="spoIIT CDS" gene complement(2079776..2079955) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /label="spoIIT gene" promotor_-10 complement(2079974..2079992) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2079989) /Source="Nicolas_upshifts" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2080007..2080013) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2080026..2080400) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406, 24164455; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390347.1" /db_xref="EnsemblGenomes-Gn:BSU24670" /db_xref="EnsemblGenomes-Tr:CAB14398" /db_xref="GOA:P25959" /db_xref="InterPro:IPR020372" /db_xref="SubtiList:BG10489" /db_xref="UniProtKB/Swiss-Prot:P25959" /translation="MYRTRGFIYPAVLFVSALVLLIVNFVAAQYISRCMFEKETKELY IGENLLQNGVLLSIRHVLEERKGQEGTQQFLYGRVSYYIHDTSIKEQKEINLRVSTDS GTERTAQIVFDQKQKKLLRWTE*" /label="comGG CDS" gene complement(2080026..2080400) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /label="comGG gene" CDS complement(2080401..2080784) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390348.1" /db_xref="EnsemblGenomes-Gn:BSU24680" /db_xref="EnsemblGenomes-Tr:CAB14399" /db_xref="GOA:P25958" /db_xref="InterPro:IPR016977" /db_xref="SubtiList:BG10488" /db_xref="UniProtKB/Swiss-Prot:P25958" /translation="MLISGSLAAIIHLFLSRQQEHDGFTQQEWMISIEQMMNECKESQ AVKTAEHGSVLICTNLSGQDIRFDIYHSMIRKRVDGKGHVPILDHITAMKADIENGVV LLKIESEDQKVYQTAFPVYSYLGGG*" /label="comGF CDS" gene complement(2080401..2080784) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /label="comGF gene" CDS complement(2080810..2081157) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /function="16.11: Scavenge (Catabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7783624, 9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390349.1" /db_xref="EnsemblGenomes-Gn:BSU24690" /db_xref="EnsemblGenomes-Tr:CAB14400" /db_xref="GOA:P25957" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR020488" /db_xref="SubtiList:BG10487" /db_xref="UniProtKB/Swiss-Prot:P25957" /translation="MWRENKGFSTIETMSALSLWLFVLLTVVPLWDKLMADEKMAESR EIGYQMMNESISKYVMSGEGAASKTITKNNHIYAMKWEEEGEYQNVCIKAAAYKEKSF CLSILQTEWLHAS*" /label="comGE CDS" gene complement(2080810..2081157) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /label="comGE gene" CDS complement(2081141..2081572) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane component of the DNA transport pilin platform" /protein_id="NP_390350.1" /db_xref="EnsemblGenomes-Gn:BSU24700" /db_xref="EnsemblGenomes-Tr:CAB14401" /db_xref="GOA:P25956" /db_xref="InterPro:IPR002416" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016785" /db_xref="SubtiList:BG10486" /db_xref="UniProtKB/Swiss-Prot:P25956" /translation="MNIKLNEEKGFTLLESLLVLSLASILLVAVFTTLPPAYDNTAVR QAASQLKNDIMLTQQTAISRQQRTKILFHKKEYQLVIGDTVIERPYATGLSIELLTLK DRLEFNEKGHPNAGGKIRVKGHAVYDITVYLGSGRVNVERK*" /label="comGD CDS" gene complement(2081141..2081572) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /label="comGD gene" CDS complement(2081562..2081858) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="pilin-like component of the DNA transport membrane pilin platform" /protein_id="NP_390351.1" /db_xref="EnsemblGenomes-Gn:BSU24710" /db_xref="EnsemblGenomes-Tr:CAB14402" /db_xref="GOA:P25955" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016940" /db_xref="SubtiList:BG10485" /db_xref="UniProtKB/Swiss-Prot:P25955" /translation="MNEKGFTLVEMLIVLFIISILLLITIPNVTKHNQTIQKKGCEGL QNMVKAQMTAFELDHEGQTPSLADLQSEGYVKKDAVCPNGKRIIITGGEVKVEH*" /label="comGC CDS" gene complement(2081562..2081858) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /label="comGC gene" CDS complement(2081872..2082843) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 15968048, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 15968048, 16850406, 24164455; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane pilin platform component of the DNA transport machinery" /protein_id="NP_390352.1" /db_xref="EnsemblGenomes-Gn:BSU24720" /db_xref="EnsemblGenomes-Tr:CAB14403" /db_xref="GOA:P25954" /db_xref="InterPro:IPR001992" /db_xref="InterPro:IPR018076" /db_xref="SubtiList:BG10484" /db_xref="UniProtKB/Swiss-Prot:P25954" /translation="MTAGGYTLLDGLRLMELQMNKRQAADLTDSVTCLREGAPFYQVL KSLSFHKEAVGICYFAETHGELPASMIQSGELLERKIAQADQLKRVLRYPLFLIFTVA VMFYMLQSIIIPQFSGIYQSMNMETSRSTDMLFAFFQHIDLVIILLVLFTAGIGIYYW LVFKKKSPARQMLICIRIPLVGKLVKLFNSYFFSLQLSSLLKSGLSIYDSLNAFKHQT FLPFYRCEAEQLIERLKAGESIESAICGSLFYETDLSKVISHGQLSGRLDRELFTYSQ FILQRLEHKAQKWTGILQPMIYGFVAAMILLVYLSMLVPMYQMMNQM*" /label="comGB CDS" gene complement(2081872..2082843) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /label="comGB gene" CDS complement(2082896..2083966) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane associated ATPase of the pilin platformfor DNA competence" /protein_id="NP_390353.1" /db_xref="EnsemblGenomes-Gn:BSU24730" /db_xref="EnsemblGenomes-Tr:CAB14404" /db_xref="GOA:P25953" /db_xref="InterPro:IPR001482" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10483" /db_xref="UniProtKB/Swiss-Prot:P25953" /translation="MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLK KRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEES LVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQY AKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRD AETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDL ACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIR KGIALGYLTTNNYDRWVYHEKD*" /label="comGA CDS" gene complement(2082896..2083966) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /label="comGA gene" promotor_-10 complement(2083984..2084003) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2084000) /Source="Nicolas_upshifts" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2084017..2084024) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2084149..2084377) /Source="Nicolas_S_feature" /locus_tag="new_2560260_2560488_c" /HighExp="Etha, Salt, Sw, Gly, LPhT, B36, Heat, B60, LoTm, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37350499999999998" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S926" downshifts complement(2084190) /Source="Nicolas_upshifts" /id="D1283" /incds=0 /nref=16 /ntot=42 /MaxReadThrough="0.95925" /MaxDrop="5.92871" /score="30.7083619" /energy="-13" /TU="NA" /idTUdmin="U1920" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2084378..2085331) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15856219, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15856219, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="CorA-type divalent ion transporter" /protein_id="NP_390354.1" /db_xref="EnsemblGenomes-Gn:BSU24740" /db_xref="EnsemblGenomes-Tr:CAB14405" /db_xref="GOA:P40948" /db_xref="InterPro:IPR002523" /db_xref="SubtiList:BG11075" /db_xref="UniProtKB/Swiss-Prot:P40948" /translation="MKAHTGKDWFWYQMGPQERSKARDLIHFSHWPQCEKWFENNHHV NFLRVDTTETENEAVFGSIVYDQGLGEEKDHTVFHFYITRQYFFTINFDFSILREIKG KEVVRQMERADNAIEGFLILLGELMNAYLIGVDEFEVKLRKLRWQIKDDNSKSILNRV HLLRHELMIWKNLILSAKKIEMALKETFLPQNEGKKDYQRTQLKIDRGFTYISEFEGE LNNLLHSEEVITSHRGNEIVKALTIFTTLFTPITALGALWGMNFSVMPELNWKYGYLF SLLLIVTSTVLIYLYLRKKGWTGDMLQERKKKKKPRKRRTL*" /label="yqxL CDS" gene complement(2084378..2085331) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /label="yqxL gene" promotor_-10 complement(2085355..2085374) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2085376) /Source="Nicolas_upshifts" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2085388..2085394) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2085414..2085420 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2085435..2085453 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2085453 /Source="Nicolas_upshifts" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="upshifts" CDS 2085474..2086802 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane associated enzyme" /protein_id="NP_390355.1" /db_xref="EnsemblGenomes-Gn:BSU24750" /db_xref="EnsemblGenomes-Tr:CAB14406" /db_xref="GOA:P54505" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11695" /db_xref="UniProtKB/Swiss-Prot:P54505" /translation="MPSLEKAVVLEFINLLAVAILILLTGFFVAVEFSIVKVRRSKID QLVAKGKKGAKAAKHVITHLDEYLSACQLGITVAALGLGWLGEPTVQTLLRPLFHKAG LNESLTHLLSLVIAFLVVTYLNVVIGELAPKSFAIQKAESITLLFAKPLIWFYKIMFP FIWLLNHSARLITGVFGLKPASEHELAYTEEELRVLLAESYKSGEIRKSELKYMNNIF TFDKRMAKEIMVPRNEMVSLSLDEDSISNLQETVKQTKYTRYPVVREDKDNVIGVINM KEVLFSMLTKDFSIKKHQIEPFVQPVIHVIETIPIYKLLLKMQKERTHMAILIDEYGG TSGLVTVEDIIEEIVGEIRDEFDADEVPHIRELGKDHYLLNAKLLISDVNSLLGTDLS EAEVDTLGGWFLTQNIDAEPESAIEYDGYSFKVKDINSHHILFIEVKKAE*" /label="yqhB CDS" gene 2085474..2086802 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /label="yqhB gene" S_feature 2086803..2087777 /Source="Nicolas_S_feature" /locus_tag="new_2562914_2563888" /HighExp="Sw, Salt, Etha, LPhT, M9-stat, S8, BC, S6, BT, Gly" /AntisenseName="rsbRD" /AntisenseCor="0.58358076577781004" /AntisenseRegPval="-25.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S927" CDS complement(2086855..2087691) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11157946, 15312768, 15583165, 16963570, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157946, 15312768, 15583165, 16963570, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_390356.2" /db_xref="EnsemblGenomes-Gn:BSU24760" /db_xref="EnsemblGenomes-Tr:CAB14407" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR025751" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11694" /db_xref="UniProtKB/Swiss-Prot:P54504" /translation="MIALDQHLTEHKKDITQQWLEVCTSNGSWLYSAKDQQKLEQKLK DQHELLVTIVAKSLRKEDVEDELNRWSLQCARDRAVHEVTVTQSVGQFNTFRHIMFEW IHKFSEASSQDISIQEFYEWSRILNQNIDEIIEVFTEEYHQVTMIQLNAQKEMINELS APIMPITDGIGILPLVGEIDTHRARTILESVLEQCSALKLSYLFLDISGVPIVDTMVA YQIFKVIDSTKLLGIETIISGIRPEIAQTVVKLGLDFSNVKTEQSLAKALANKGFKIK EC*" /label="rsbRD CDS" gene complement(2086855..2087691) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /label="rsbRD gene" S_feature complement(2087692..2087876) /Source="Nicolas_S_feature" /locus_tag="new_2563803_2563987_c" /HighExp="Etha, LoTm, Salt, Heat, Gly, M9-stat, B60, S8, S0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147982" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S928" tRNA 2087778..2087848 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln (UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Gln1 tRNA" gene 2087778..2087848 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /label="trnSL-Gln1 gene" CDS complement(2087915..2088295) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:18643936, 22812682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18643936, 22812682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of stress" /protein_id="NP_390357.2" /db_xref="EnsemblGenomes-Gn:BSU24770" /db_xref="EnsemblGenomes-Tr:CAB14408" /db_xref="GOA:P54503" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11693" /db_xref="UniProtKB/Swiss-Prot:P54503" /translation="MEQQLTFYSYPSCTSCRKTKHWLKAHQIEFNERHLFRETPTREE LKYILSLTTEGIDEILATRSQTFKNLNLNIEEMTVNEVLELLIEKPKLLRRPILVDNK KLVIGYNPGELLKLSKKKTVHQSA*" /label="mgsR CDS" gene complement(2087915..2088295) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /label="mgsR gene" downshifts complement(2087921) /Source="Nicolas_upshifts" /id="D1284" /incds=0 /nref=9 /ntot=174 /MaxReadThrough="6.12556" /MaxDrop="6.72616" /score="0.164931099" /energy="-19.7" /TU="U1922" /idTUdmin="U1925" /TUdmin=912 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2088324..2088342) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2088343) /Source="Nicolas_upshifts" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2088357..2088363) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2088382..2088387 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-35" promotor_-10 2088403..2088421 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-10" upshifts 2088412 /Source="Nicolas_upshifts" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="upshifts" promotor_-35 2088462..2088469 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-35" upshifts 2088484 /Source="Nicolas_upshifts" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="upshifts" promotor_-10 2088485..2088504 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-10" CDS 2088527..2088772 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390358.1" /db_xref="EnsemblGenomes-Gn:BSU24780" /db_xref="EnsemblGenomes-Tr:CAB14409" /db_xref="GOA:P54502" /db_xref="InterPro:IPR020254" /db_xref="SubtiList:BG11692" /db_xref="UniProtKB/Swiss-Prot:P54502" /translation="MNRMFRVLGFWTGIFAVMFYLGDMKDASLLFFGQTILFVFLSYL NLTERMYIYIFGAYLTIFFAGFTYYSIFIMVPGGGGH*" /label="yqgY CDS" gene 2088527..2088772 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /label="yqgY gene" downshifts 2088669 /Source="Nicolas_upshifts" /id="D1285" /incds=1 /nref=1 /ntot=86 /MaxReadThrough="6.68961" /MaxDrop="2.1025" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=176 /isTUend="FALSE" /label="downshifts" downshifts 2088758 /Source="Nicolas_upshifts" /id="D1286" /incds=0 /nref=98 /ntot=234 /MaxReadThrough="4.03872" /MaxDrop="5.76938" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=265 /isTUend="FALSE" /label="downshifts" S_feature 2088803..2089558 /Source="Nicolas_S_feature" /locus_tag="new_2564914_2565669" /HighExp="M9-stat, T0.30H, T1.30H, LoTm, T1.0H, B60, T2.0H, S5, S4, T2.30H" /AntisenseName="yqgX" /AntisenseCor="-0.68109878166952498" /AntisenseRegPval="-37.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S929" CDS complement(2088812..2089447) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20669241, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-binding hydrolase" /protein_id="NP_390359.1" /db_xref="EnsemblGenomes-Gn:BSU24790" /db_xref="EnsemblGenomes-Tr:CAB14410" /db_xref="GOA:P54501" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11691" /db_xref="UniProtKB/Swiss-Prot:P54501" /translation="MKWRRMPVGPIQANAYFLISDDQCLIFDPGGEGHKINQYIKEKG LTPLAILLTHAHFDHIGALDEVREKWDIPVYLHQNEKNWLADASLNGSGMLRGIEVTA KPADHLIEGDGELNIGPFHLETLFTPGHSPGSVSYYVKDADLVISGDVLFQGGIGRTD LIGGNQETLLTSIHEKLLTLPEHTLVLSGHGPETDVLTEQDQNPFLNGFSL*" /label="yqgX CDS" gene complement(2088812..2089447) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /label="yqgX gene" downshifts complement(2088837) /Source="Nicolas_upshifts" /id="D1287" /incds=0 /nref=154 /ntot=239 /MaxReadThrough="1.42757" /MaxDrop="5.15622" /score="-8.36666809" /energy="-13.7" /TU="NA" /idTUdmin="U1925" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2089469..2089488) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2089486) /Source="Nicolas_upshifts" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2089502..2089509) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2089526..2089533 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2089548..2089567 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2089560 /Source="Nicolas_upshifts" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2089580) /Source="Nicolas_upshifts" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2089582..2089596) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2089604..2089608) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2089604..2089777 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390360.1" /db_xref="EnsemblGenomes-Gn:BSU24800" /db_xref="EnsemblGenomes-Tr:CAB14411" /db_xref="GOA:P54500" /db_xref="InterPro:IPR024490" /db_xref="SubtiList:BG11690" /db_xref="UniProtKB/Swiss-Prot:P54500" /translation="MLLVVIFGLVALFALWGVLRSVRNKNILGFLLAGATLFVFGWFT VMTVINSGYPTAH*" /label="yqgW CDS" gene 2089604..2089777 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /label="yqgW gene" downshifts 2089765 /Source="Nicolas_upshifts" /id="D1288" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="3.92092" /MaxDrop="7.18555" /score="14.1643615" /energy="-12.4" /TU="U1926" /idTUdmin="U1924" /TUdmin=217 /isTUend="FALSE" /label="downshifts" CDS complement(2089809..2090123) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390361.2" /db_xref="EnsemblGenomes-Gn:BSU24810" /db_xref="EnsemblGenomes-Tr:CAB14412" /db_xref="GOA:P54499" /db_xref="InterPro:IPR002767" /db_xref="InterPro:IPR029756" /db_xref="SubtiList:BG11689" /db_xref="UniProtKB/Swiss-Prot:P54499" /translation="MAIADVTIIPIGTETPSVSAYVADVQKILEGYQAEGKIKYQLTP MNTLIEGELSDLFAVIQAIHEAPFQKGLHRVATNIRIDDRRDKKTTLESKIESVNKHL QP*" /label="yqgV CDS" gene complement(2089809..2090123) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /label="yqgV gene" S_feature 2089810..2090877 /Source="Nicolas_S_feature" /locus_tag="new_2565921_2566988" /HighExp="LoTm, M9-stat, C30, Cold, S8, S7, B60, Lbstat, G135, C90" /AntisenseName="yqgV" /AntisenseCor="-0.23995763414552801" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigEF" /TUlongPSig="1, 1" /label="S930" downshifts complement(2089823) /Source="Nicolas_upshifts" /id="D1289" /incds=0 /nref=247 /ntot=265 /MaxReadThrough="2.24429" /MaxDrop="6.85096" /score="0.185625845" /energy="-12.4" /TU="NA" /idTUdmin="U1928" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2090126..2091187) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390362.2" /db_xref="EnsemblGenomes-Gn:BSU24820" /db_xref="EnsemblGenomes-Tr:CAB14413" /db_xref="GOA:P54498" /db_xref="SubtiList:BG11688" /db_xref="UniProtKB/Swiss-Prot:P54498" /translation="MLMRSVCFILLAVLLFSLSACEPSHQQQKQASAAKDEKKDIIPL SAEKADGAEGWLNNSTILYTASNPTKTELFAYRIFTGKAKKLYQTDGQIVDVQINARE QMILLQITHSQKTAVVLLNAEGETLYEKDYETYELEAAWNQYDPYQMMVTEFNENWDF HTYQVNAKKDESFLSPVQVPFIHWTSKNTFDYVKEGRDDKTGPLYTFDTASKTEQKLE DNVLFFDSFHQMSFTVKSASGGKGTYQFKTPQSTSPVTAKWPLQAKYTSLAPMEYDYD EAGGLFYTFKQSGDAYKLAAINVASGETKDLVSLREMEPIQISPNGKYALYGFHFEQI ILLKSHETKQLIIDQKEME*" /label="yqgU CDS" gene complement(2090126..2091187) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /label="yqgU gene" CDS complement(2091249..2092379) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12765833, 24163346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative d,l-endopeptidase" /protein_id="NP_390363.1" /db_xref="EnsemblGenomes-Gn:BSU24830" /db_xref="EnsemblGenomes-Tr:CAB14414" /db_xref="GOA:P54497" /db_xref="InterPro:IPR000834" /db_xref="InterPro:IPR034274" /db_xref="SubtiList:BG11687" /db_xref="UniProtKB/Swiss-Prot:P54497" /translation="MMAFITVKPEIKNNLANVAKELKIDEELLKSANRSAQKHQLYCP GYVIEEHSGKELQTIQDIKRFLQPRQLKLSDSWIEQEKIYDDSAVEKEIKKIIDVFPF VSCREIGRSVLGRPIWELKAGGEHAVKKVHMNASFHANEWITTSVLLKWFKEYCMSLC CNSPFFGFSPIKLFNSTSLSLVPLVNPDGVDLVLNGSEVMGARRDELERLNEHRPNFN EWKANINGVDLNKQFPSLWEIEKYRKPTAPSYRDFPGISPLTEPESIAMYRLITENPP DRLLALHTQGEEIYWGYKGLEPEESAAVIKEFEELSGNIYKGVRDIDSYAGFRDWFIH HYFKEGYTVELGKGQNPLPFQQFSHIYNATSGILWRALFFHE*" /label="yqgT CDS" gene complement(2091249..2092379) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /label="yqgT gene" promotor_-10 complement(2092387..2092405) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2092419) /Source="Nicolas_upshifts" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2092421..2092426) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2092462..2094378) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647, 25666134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647, 25666134; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_390364.2" /db_xref="EnsemblGenomes-Gn:BSU24840" /db_xref="EnsemblGenomes-Tr:CAB14415" /db_xref="GOA:P54496" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG11686" /db_xref="UniProtKB/Swiss-Prot:P54496" /translation="MRKTFFSKISFMLIAILLMWLKTYAVYKTSFHIKIDNLTQEFIL FINPLSFLLLIFGLSLFLKGKNRNRYIIAMSCLVTFVLLANMVFYRFYNDFLTIPVLF QTSNMGDLGSSIGTLLEPTDLLLAVDIAVLIWLHIRQKAFQSDIPSTKNERAAYFLFV ASVYFFNLGLSEAERPQLLTRSFDREMLVKNISLFNFHIYDGVLQSKQSAQRALADSN SLTEIENYVTANAKDANKRLFGAAKGRNVILVSLESTQSFVINEKLNGEEITPFLNDF IKQSYNFNNVYHQTGQGKTSDSEFIVDNSLYPLGRGAVFFTNAGNQYMAAPEILKNSG YYSAVLHANNKSFWNRDLMYDSFGYDSFFDINSYDVTDENSVGWGLKDKEFFEQSSEL MKNLPQPFYSRLITLTNHFPFDLDEEDQLIDEYDSNSQTLNKYFPTVRYQDEALKRFI EKLKEDGLYDNSVIVLYGDHYGISENHNEAMGQFLGKEITPFEEVQLQKVPLVIHIPG ITDKKPQTIETVGGQIDIRPTLMNLLGIDTKDQIQFGNDLLSDEKLDFTVLRDGSFIT DQVVYTDGACYDKETGKPLEETKQCEAFADKAKQELSLSDEIIYGDLLRFYDQKRLDN SSKRKEKQMLDQAS*" /label="ltaSC CDS" gene complement(2092462..2094378) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /label="ltaSC gene" downshifts complement(2092489) /Source="Nicolas_upshifts" /id="D1290" /incds=0 /nref=5 /ntot=142 /MaxReadThrough="4.5611" /MaxDrop="3.8416" /score="15.4764643" /energy="-14.5" /TU="U1930,U1931" /idTUdmin="U1928" /TUdmin="-2667" /isTUend="FALSE" /label="downshifts" promotor_-35 2093494..2093500 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2093513..2094542 /Source="Nicolas_S_feature" /locus_tag="new_2569624_2570653" /HighExp="Etha, Gly, M9-stat, Salt, S8, LPhT, S7, Sw, HiTm, B60" /AntisenseName="yqgS" /AntisenseCor="-0.36996929809172002" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S931" upshifts 2093513 /Source="Nicolas_upshifts" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2093516..2093534 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(2094379..2094445) /Source="Nicolas_S_feature" /locus_tag="new_2570490_2570556_c" /HighExp="T-3.40H, BC, Sw, S5, Lbstat, T-5.40H, S4, ferm, C30, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S932" promotor_-10 complement(2094439..2094458) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2094445) /Source="Nicolas_upshifts" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2094473..2094480) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2094495..2095460) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /EC_number="2.7.1.59" /EC_number="2.7.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose kinase" /protein_id="NP_390365.2" /db_xref="EnsemblGenomes-Gn:BSU24850" /db_xref="EnsemblGenomes-Tr:CAB14416" /db_xref="GOA:P54495" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR004654" /db_xref="SubtiList:BG11685" /db_xref="UniProtKB/Swiss-Prot:P54495" /translation="MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITV TIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETE TGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGG EIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSAR DVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVE KTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC*" /label="glcK CDS" gene complement(2094495..2095460) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /label="glcK gene" CDS complement(2095471..2095686) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /function="9.3: Transcription factors" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15050034, 20057058; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative single strand nucleic acid binding transcription factor" /protein_id="NP_390366.1" /db_xref="EnsemblGenomes-Gn:BSU24860" /db_xref="EnsemblGenomes-Tr:CAB14417" /db_xref="InterPro:IPR009256" /db_xref="InterPro:IPR023164" /db_xref="PDB:2NN4" /db_xref="SubtiList:BG11684" /db_xref="UniProtKB/Swiss-Prot:P54494" /translation="MNTFYDVQQLLKTFGHIVYFGDRELEIEFMLDELKELYMNHMIE KEQWARAAAVLRKELEQTKNGRDFYKG*" /label="yqgQ CDS" gene complement(2095471..2095686) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /label="yqgQ gene" S_feature complement(2095687..2095795) /Source="Nicolas_S_feature" /locus_tag="new_2571798_2571906_c" /HighExp="M0t90, Lbstat, M40t90, M40t45, Lbtran, Mt0, dia5, Diami, M0t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S933" CDS complement(2095796..2097319) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /EC_number="3.4.21.105" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15050034, 16355228, 23518036, 26858402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane endopeptidase" /protein_id="NP_390367.2" /db_xref="EnsemblGenomes-Gn:BSU24870" /db_xref="EnsemblGenomes-Tr:CAB14418" /db_xref="GOA:P54493" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG11683" /db_xref="UniProtKB/Swiss-Prot:P54493" /translation="MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLV RLYKHDLDFRQEMVRDIEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKK TFEKGTVSVEPAIVRGTMLRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLK QEEQRKTEAAVFQNGKPTFTYLFIALQILMFFLLEINGGSTNTETLVAFGAKENSLIA QGEWWRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIAS FVFSPYPSAGASGAIFGCLGALLYVALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNI DNSGHIGGLIGGFFAAAALGLPKAGAFGKRLLSAVLLIALAVGFLYYGLHSPSHQESA LIQQASELYQEGKYEEVTELLNGEAAQKDASADLLKILAVSDIQIGEYDQAVSLLERA VKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES* " /label="glpG CDS" gene complement(2095796..2097319) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /label="glpG gene" promotor_-10 complement(2097337..2097356) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2097350) /Source="Nicolas_upshifts" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2097371..2097378) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2097409..2097582) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390368.1" /db_xref="EnsemblGenomes-Gn:BSU24880" /db_xref="EnsemblGenomes-Tr:CAB14419" /db_xref="SubtiList:BG11682" /db_xref="UniProtKB/Swiss-Prot:P54492" /translation="MKKLLIYAIFAVSAVMFYQNRYRLMNTVLSQPGIRRSFIHLFLR IPFIRNKFIQQAF*" /label="yqgO CDS" gene complement(2097409..2097582) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /label="yqgO gene" downshifts complement(2097436) /Source="Nicolas_upshifts" /id="D1291" /incds=0 /nref=121 /ntot=211 /MaxReadThrough="2.93694" /MaxDrop="5.6047" /score="19.2452946" /energy="-8.9" /TU="NA" /idTUdmin="U1932" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2097598..2097609) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2097610) /Source="Nicolas_upshifts" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2097623..2097629) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2097649..2098212) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /EC_number="6.3.3.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17329806, 20952389, 22773193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-formyltetrahydrofolate cyclo-ligase" /protein_id="NP_390369.1" /db_xref="EnsemblGenomes-Gn:BSU24890" /db_xref="EnsemblGenomes-Tr:CAB14420" /db_xref="GOA:P54491" /db_xref="InterPro:IPR002698" /db_xref="PDB:1YDM" /db_xref="SubtiList:BG11681" /db_xref="UniProtKB/Swiss-Prot:P54491" /translation="MKSQLRKKTLEALSALSNEDILQKTERMYKYLFSLPEWQNAGTI AVTISRGLEIPTRPVIEQAWEEGKQVCIPKCHPDTKKMQFRTYQTDDQLETVYAGLLE PVIEKTKEVNPSQIDLMIVPGVCFDVNGFRVGFGGGYYDRYLSEYEGKTVSLLLECQL FAHVPRLPHDIPVHKLITEDRIISCFS*" /label="folN CDS" gene complement(2097649..2098212) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /label="folN gene" S_feature complement(2098213..2098296) /Source="Nicolas_S_feature" /locus_tag="new_2574324_2574407_c" /HighExp="Cold, G180, LBGexp, LBGtran, G135, HPh, LPh, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S934" CDS complement(2098297..2098446) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12904577, 19648245, 22720735, 23002217, 27561249; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_570908.2" /db_xref="EnsemblGenomes-Gn:BSU24900" /db_xref="EnsemblGenomes-Tr:CAE01461" /db_xref="GOA:P56849" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG14180" /db_xref="UniProtKB/Swiss-Prot:P56849" /translation="MRVNITLACTECGERNYISKKNKRNNPDRVEFKKYCPRDKKSTL HRETK*" /label="rpmGA CDS" gene complement(2098297..2098446) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /label="rpmGA gene" downshifts complement(2098343) /Source="Nicolas_upshifts" /id="D1292" /incds=0 /nref=154 /ntot=253 /MaxReadThrough="5.3064" /MaxDrop="4.5881" /score="34.7393253" /energy="-15.3" /TU="U1933" /idTUdmin="U1932" /TUdmin="-907" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2098483..2098502) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2098493) /Source="Nicolas_upshifts" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2098518..2098521) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2098530..2099609) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_390370.2" /db_xref="EnsemblGenomes-Gn:BSU24910" /db_xref="EnsemblGenomes-Tr:CAB14421" /db_xref="GOA:P54490" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11680" /db_xref="UniProtKB/Swiss-Prot:P54490" /translation="MNILMLSPEHPDEPKSGLGVHLNRLISYLNPHINITVFTPSGQL FSYAKFEDYIADANFTMVRHVLSHNKRFDLIHAHDDTTAPAAQYLKQRLGLPLAATIH GLESERKKVCREAPHPYRLMTERLLIESADALIVLSTFMKRSLDKAAHKKITVIPSPA SMEEEKGKIPRSMNRRFLFSYGRFVPEKGLSQLLKVFAILKQRQPDLYLVLAGEGPSL SCYEKLAAAYNLKDRVMFLPFLNRKDIRTLLSHCEMAVFPSSYEPFGLAAQESMEQGV LTVVSQSGGFCDYAVHDKTAIIADFTLVQEAADLLDSFLKDREKARRIKEAGRQQVFK LHHPRLIMSSYLQLYERIFNNSAIH*" /label="yqgM CDS" gene complement(2098530..2099609) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /label="yqgM gene" CDS complement(2099606..2100076) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390371.1" /db_xref="EnsemblGenomes-Gn:BSU24920" /db_xref="EnsemblGenomes-Tr:CAB14422" /db_xref="SubtiList:BG11679" /db_xref="UniProtKB/Swiss-Prot:P54489" /translation="MDKHPFPYNIRHKLSFFRDTFDIIIQNAHTLTVSWEISEETMRL AEAVLFEKTQDMIKELRIVIKRKDIEAVRTKRTTYDKGEWTIRQAAGDAVYRAEYRIV NSMNVSLKLAGTDDIYLDENGIRHINSFQIEEAHTRWEAQFSAYTCYGRGEKER*" /label="yqgL CDS" gene complement(2099606..2100076) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /label="yqgL gene" promotor_-35 2100021..2100029 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2100043..2100051 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2100044..2100217 /Source="Nicolas_S_feature" /locus_tag="new_2576155_2576328" /HighExp="M9-stat, T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, Lbstat, T3.30H, B60" /AntisenseName="yqgL" /AntisenseCor="0.210779859401483" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S935" upshifts 2100045 /Source="Nicolas_upshifts" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2100112..2100131) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2100124) /Source="Nicolas_upshifts" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2100143..2100150) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2100189..2100193 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2100209..2100228 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2100219 /Source="Nicolas_upshifts" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" CDS 2100256..2100609 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390372.1" /db_xref="EnsemblGenomes-Gn:BSU24930" /db_xref="EnsemblGenomes-Tr:CAB14423" /db_xref="GOA:O32022" /db_xref="SubtiList:BG13770" /db_xref="UniProtKB/Swiss-Prot:O32022" /translation="MEIAIIALFIVSIALIAFSYSQRDPMKDVEQELETLQLSAMQEI YKLKKKMTVLEEELLETNLVIRKSKQNDINQKIAKQILSKYNNGMSAEAIAKAEHVSV EDVNTIIKDNEKVLV*" /label="yqzD CDS" gene 2100256..2100609 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /label="yqzD gene" CDS 2100606..2101070 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390373.2" /db_xref="EnsemblGenomes-Gn:BSU24940" /db_xref="EnsemblGenomes-Tr:CAB14424" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13769" /db_xref="UniProtKB/Swiss-Prot:O32023" /translation="MTKRGIQAFAGGIILATAVLAAVFYLTDEDQAAAVKDNKTVTEQ DVNNYLDSKKLVSVNRDEYQKLLDSKEKSLNNDSGSDTKSDKVKTYKLTIKDGMSTAD VSAILEKEGIISSAQDFNDYVIDAGYHKEIRAGEFKVKSDMSFKKIVKTLTR*" /label="yqzC CDS" gene 2100606..2101070 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /label="yqzC gene" downshifts 2101056 /Source="Nicolas_upshifts" /id="D1293" /incds=0 /nref=216 /ntot=264 /MaxReadThrough="0.9847" /MaxDrop="6.07831" /score="21.2108939" /energy="-8.8" /TU="NA" /idTUdmin="U1934" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2101099..2101881) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390374.1" /db_xref="EnsemblGenomes-Gn:BSU24950" /db_xref="EnsemblGenomes-Tr:CAB14425" /db_xref="GOA:P46342" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11379" /db_xref="UniProtKB/Swiss-Prot:P46342" /translation="MSIATEAVMKQEVYQVNGMNLWYGQHHALKNINLSIYENEVTAI IGPSGCGKSTFIKTLNLMIQMTPNVKLAGELNYNGSNILKDKVDIVDLRKNIGMVFQK GNPFPQSIFDNVAYGPRVHGTKNKKKLQEIVEKSLKDVALWDEVKDRLHTSALSLSGG QQQRLCIARALATNPDILLMDEPTSALDPISTRKIEELILELKDKYTIVIVTHNMQQA ARVSDQTAFFYMGELVECDNTNKMFSNPKDQRTLDYISGKFG*" /label="pstBB CDS" gene complement(2101099..2101881) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /label="pstBB gene" downshifts complement(2101110) /Source="Nicolas_upshifts" /id="D1294" /incds=0 /nref=20 /ntot=46 /MaxReadThrough="2.29658" /MaxDrop="6.53816" /score="26.1659198" /energy="-8.8" /TU="NA" /idTUdmin="U1937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2101892..2102701) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390375.1" /db_xref="EnsemblGenomes-Gn:BSU24960" /db_xref="EnsemblGenomes-Tr:CAB14426" /db_xref="GOA:P46341" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11378" /db_xref="UniProtKB/Swiss-Prot:P46341" /translation="MSEQMVKEKPERAVIVPKQNHVLEVKDLSIYYGNKQAVHHVNMD IEKNAVTALIGPSGCGKSTFLRNINRMNDLIPSARAEGEILYEGLNILGGNINVVSLR REIGMVFQKPNPFPKSIYANITHALKYAGERNKAVLDEIVEESLTKAALWDEVKDRLH SSALSLSGGQQQRLCIARTLAMKPAVLLLDEPASALDPISNAKIEELITGLKREYSII IVTHNMQQALRVSDRTAFFLNGELVEYGQTEQIFTSPKKQKTEDYINGKFG*" /label="pstBA CDS" gene complement(2101892..2102701) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /label="pstBA gene" CDS complement(2102722..2103606) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390376.2" /db_xref="EnsemblGenomes-Gn:BSU24970" /db_xref="EnsemblGenomes-Tr:CAB14427" /db_xref="GOA:P46340" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR005672" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11377" /db_xref="UniProtKB/Swiss-Prot:P46340" /translation="MNRKITDKLATGMFGLCAAIIAAILVGLFSYIIINGVSQLSFQF ITTKSSAIAAGGGIRDQLFNSFYILFITMLITIPLGVGGGVFMAEYAPNNKVTDFIRT CIEVLSSLPSIVIGMFGLLMFVNLTGWGYTIIGGALALTVFNLPVMVRVTEDAIRSVP KDLKEASLALGVSRWHTVKTVLIPSAIPSIITGAILASGRVFGEAAALLFTAGLTTPR LNFTEWNPFSETSPLNIFRPAETLAVHIWNVNTQGMIPDAEAIANGGSAVLVISVLVF NLAARWLGTMIYKKLTAN*" /label="pstA CDS" gene complement(2102722..2103606) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /label="pstA gene" CDS complement(2103606..2104535) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390377.2" /db_xref="EnsemblGenomes-Gn:BSU24980" /db_xref="EnsemblGenomes-Tr:CAB14428" /db_xref="GOA:P46339" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011864" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11376" /db_xref="UniProtKB/Swiss-Prot:P46339" /translation="MINNRENMSVSERLISSRQNRQLDEVRGRMIVTACALIMIAASV AITIFLGVKGLQSFLVNGVSPIEFLTSLNWNPTDSDPKYGVLPFIFGSFAVTILSALI AAPLGIAGAIFMTEIAPNWGKKVLQPVIELLVGIPSVVYGFIGLTVLVPFIAQFKSSG TGHSLLAGTIVLSVMILPTITSISADAMASLPKSLREGSYALGATRWQTIRKVLVPAA FPTLMTAVVLGMARAFGEALAVQMVIGNTRVLPESPFDTAGTLTTIITLNMGHTTYGS VENNTLWSMGLVLLVMSFLFILLIRYLSSRRKV*" /label="pstC CDS" gene complement(2103606..2104535) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /label="pstC gene" CDS complement(2104604..2105506) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 9593301, 10913081, 15289558, 21461370, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 9593301, 10913081, 15289558, 21461370, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (phosphate binding lipoprotein)" /protein_id="NP_390378.1" /db_xref="EnsemblGenomes-Gn:BSU24990" /db_xref="EnsemblGenomes-Tr:CAB14429" /db_xref="GOA:P46338" /db_xref="InterPro:IPR011862" /db_xref="InterPro:IPR024370" /db_xref="SubtiList:BG11375" /db_xref="UniProtKB/Swiss-Prot:P46338" /translation="MKKNKLVLMLLMAAFMMIAAACGNAGESKKSNSDSAKGEEKASG SLTISGSSAMQPLVLAAAEKFMEENPDADIQVQAGGSGTGLSQVSEGAVQIGNSDVFA EEKEGIDAKALVDHQVAVVGMAAAVNPDAGVKDISKDELKKIFTGKIKNWKELGGKDQ KITLVNRPDSSGTRATFVKYALDGAEPAEGITEDSSNTVKKIIADTPGAIGYLAFSYL TDDKVTALSIDGVKPEAKNVATGEYPIWAYQHSYTKGEATGLAKEFLDYLKSEDIQKS IVTDQGYIPVTDMKVTRDANGKQS*" /label="pstS CDS" gene complement(2104604..2105506) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /label="pstS gene" upshifts complement(2105561) /Source="Nicolas_upshifts" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2105569..2105585) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2105596..2105598) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-35" Polymorphism join(2105615,2105617) /Source="geneious" /ID="SNP_BsDelta6_2581727_2581726" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)6 -> (T)7" /Codon_Change /Coverage=117 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=114 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2105661..2107811) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /EC_number="3.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9139922, 9851991, 12896990, 17307860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139922, 9851991, 12896990, 17307860; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transpeptidase (penicillin-binding protein 2A)" /protein_id="NP_390379.1" /db_xref="EnsemblGenomes-Gn:BSU25000" /db_xref="EnsemblGenomes-Tr:CAB14430" /db_xref="GOA:P54488" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11678" /db_xref="UniProtKB/Swiss-Prot:P54488" /translation="MRRNKPKKQNHKEKKKSLPIRLNILFLAAFVIFTWIIVELGIKQ IVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSTTQEQR LKIAKKLSDMIKVDTKKVTERDKKDYWILTRPKEAKKLISSKERQQVEDKKISDDDLY QLQLKRITDKQLNELTDKDMQILAIKRQMDSGYALTPQYIKNEDVSAKEMAVVSEHLD ELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNLLDHYLSLGYSRNDRVGKSY LEYQYESLLQGQKAKVENITDSKGNVTGTKTVSEGKAGKDLVLTIDIDLQKSVEKIIE KKLKAAKARPSTELLDRAFVVMMDPRNGEVLTMAGKQIKRENGAYKFDDYALGAMTSS YAMGSAVKGATVLTGLQTGAINLNTVFKDEPLYIGQDKRGKKSWQNLGPVGIQTALEK SSNVFMFKTAIAVGKGEYKPHQALPLDTSAFDTFRNYFSQFGLGVKTGIDLPNEMTGY KGTSRLSGFLLDFAIGQYDTYTPLELAQYVSTIANGGYRMKPQLVKEVRDSNAKKGIG AVVDSVQPEVLNKVDMKSSYIEEVQAGFRRVATKGTAAGQLASASYKPAAKTGTAQSF YDGPDKSKTGTDTYNTTLVAYAPADNPEIAISVVVPWTYIDYNQRYSITNEIGREVMD KYFELKSKQDKEGTQQKNKDKIEENAENTTSSDN*" /label="pbpA CDS" gene complement(2105661..2107811) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /label="pbpA gene" downshifts complement(2105671) /Source="Nicolas_upshifts" /id="D1295" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="1.22121" /MaxDrop="8.82988" /score="31.2726004" /energy="-10" /TU="U1940" /idTUdmin="U1938" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2106405..2106423) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2106413) /Source="Nicolas_upshifts" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2106439..2106445) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2107100..2107119) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2107117) /Source="Nicolas_upshifts" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2107133..2107142) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2107861..2107880) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2107866) /Source="Nicolas_upshifts" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2107896..2107900) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2107925..2109217) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390380.2" /db_xref="EnsemblGenomes-Gn:BSU25010" /db_xref="EnsemblGenomes-Tr:CAB14431" /db_xref="GOA:P54487" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11677" /db_xref="UniProtKB/Swiss-Prot:P54487" /translation="MSKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVYLWK QSGKFIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGE TAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIV AGFVISRLENNTGYTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSKVFGERHSNMN WRRITNAHFFQGLREGIFVFLISVFVFIETNSELALGTFGLVNSAVSFFAYYFASRLI KKKARKKSILLGGLILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVI GRARHARKARIEYIVLREMFLNAGRIVSILCFLLIVALLKEDVGIPLSLAILGIGHPL IYYFVKDIRFKEKEGENETMEEDGQKRVTEPTLLKGER*" /label="yqgE CDS" gene complement(2107925..2109217) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /label="yqgE gene" promotor_-10 complement(2109240..2109251) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2109251) /Source="Nicolas_upshifts" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2109265..2109271) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2109324..2109932) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /EC_number="1.15.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Mn[2+]-dependent)" /protein_id="NP_390381.3" /db_xref="EnsemblGenomes-Gn:BSU25020" /db_xref="EnsemblGenomes-Tr:CAB14432" /db_xref="GOA:P54375" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="PDB:2RCV" /db_xref="SubtiList:BG11676" /db_xref="UniProtKB/Swiss-Prot:P54375" /translation="MAYELPELPYAYDALEPHIDKETMTIHHTKHHNTYVTNLNKAVE GNTALANKSVEELVADLDSVPENIRTAVRNNGGGHANHKLFWTLLSPNGGGEPTGALA EEINSVFGSFDKFKEQFAAAAAGRFGSGWAWLVVNNGKLEITSTPNQDSPLSEGKTPI LGLDVWEHAYYLNYQNRRPDYISAFWNVVNWDEVARLYSEAK*" /label="sodA CDS" gene complement(2109324..2109932) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /label="sodA gene" downshifts complement(2109339) /Source="Nicolas_upshifts" /id="D1296" /incds=0 /nref=265 /ntot=268 /MaxReadThrough="4.329" /MaxDrop="9.16338" /score="3.26408916" /energy="-8.1" /TU="U1943" /idTUdmin="U1942" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2109984..2110003) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2109995) /Source="Nicolas_upshifts" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2109997..2110065) /Source="Nicolas_S_feature" /locus_tag="new_2586107_2586175_c" /HighExp="Etha, Salt, Heat, LPhT, Gly, Sw, S4, LoTm, M9-stat, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigB" /TUlongPSig="0.999" /label="S936" promotor_-35 complement(2110018..2110025) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2110056..2110074) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2110065) /Source="Nicolas_upshifts" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2110089..2110095) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2110111..2110593) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390382.1" /db_xref="EnsemblGenomes-Gn:BSU25030" /db_xref="EnsemblGenomes-Tr:CAB14433" /db_xref="GOA:P54486" /db_xref="InterPro:IPR007403" /db_xref="SubtiList:BG11675" /db_xref="UniProtKB/Swiss-Prot:P54486" /translation="MDMLYWLLIAAVFIIAFIGLVYPVIPSVVFIVAGFVLYGFLFSF SPYSYMFWLVEAVFAAVLFAADYVSNLLGVKRFGGSKAAIWGSTIGLLIGPFVIPVAG IILGPFIGAVCAELIVHQKDLKSAFKIGLGSLIGFLTGVIAKGIIQLLMIGYFLWTVL *" /label="yqgC CDS" gene complement(2110111..2110593) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /label="yqgC gene" S_feature complement(2110594..2110886) /Source="Nicolas_S_feature" /locus_tag="new_2586704_2586996_c" /HighExp="Etha, Gly, Salt, aero, S0, LoTm, HiTm, LPh, nit, ferm" /AntisenseName="yqgB" /AntisenseCor="9.8584854910492598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S937" promotor_-35 2110636..2110642 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2110657..2110676 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2110670 /Source="Nicolas_upshifts" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="upshifts" CDS 2110703..2111470 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15294815; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390383.2" /db_xref="EnsemblGenomes-Gn:BSU25040" /db_xref="EnsemblGenomes-Tr:CAB14434" /db_xref="GOA:P54485" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG11674" /db_xref="UniProtKB/Swiss-Prot:P54485" /translation="MNVFQLFIKSTYSPRDIAKTRFQGIGKAILYVFLLSVLFAIPTA YYVSTGTVKSMNGFKTVLNKDFPDFTISNGKLQTDEKKATESQANGFVIVFDPTDSYG TEQIEAKQNAIGILQNKFVLAIDGQAQEMSYSMMPSELQKKDVIAGLNQNKAMIVTVL SALIFLVTAAGKFIEVSFLALIGLIIKNSQKKHLSYHQLWKLSAYSITLSTVFFTIMR ALEATVPSEFLLNWFVNFVILFLVLKEIPSKKVINKS*" /label="yqgB CDS" gene 2110703..2111470 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /label="yqgB gene" promotor_-10 complement(2110884..2110902) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-10" upshifts complement(2110886) /Source="Nicolas_upshifts" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="upshifts" S_feature complement(2110888..2111824) /Source="Nicolas_S_feature" /locus_tag="new_2586998_2587934_c" /HighExp="S0, S1, aero, M0t45, HPh, Lbtran, LPh, GM 120, nit, M/G" /AntisenseName="yqgB" /AntisenseCor="0.31978785018705103" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S938" promotor_-35 complement(2110916..2110922) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-35" S_feature 2111471..2111901 /Source="Nicolas_S_feature" /locus_tag="new_2587581_2588011" /HighExp="C30, HiOs, UNK1, Gly, Fru, S8, Salt, MG 5, S7, MG 25" /AntisenseName="yqgA" /AntisenseCor="0.170248276038857" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.731" /TUlongSig="NA" /TUlongPSig="NA" /label="S939" downshifts 2111858 /Source="Nicolas_upshifts" /id="D1297" /incds=0 /nref=5 /ntot=131 /MaxReadThrough="3.89102" /MaxDrop="3.29021" /score="30.8580926" /energy="-13.8" /TU="U1944" /idTUdmin="U1944" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(2111869) /Source="Nicolas_upshifts" /id="D1298" /incds=0 /nref=15 /ntot=207 /MaxReadThrough="6.7306" /MaxDrop="3.9194" /score="7.48192829" /energy="-14.3" /TU="U1947" /idTUdmin="U1945" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" CDS complement(2111886..2112314) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /experiment="publication(s) with functional evidences, PMID:25130749, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25130749, 27797724; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="cell wall protein" /protein_id="NP_390384.2" /db_xref="EnsemblGenomes-Gn:BSU25050" /db_xref="EnsemblGenomes-Tr:CAB14435" /db_xref="GOA:P54484" /db_xref="SubtiList:BG11673" /db_xref="UniProtKB/Swiss-Prot:P54484" /translation="MKQGKFSVFLILLLMLTLVVAPKEKAEAASSGWQPVSGISGCKI RVITDAYTYTKSATSIDAYAETNGKCGKLNYKSFGVSIVEGGDIGPQYSGYFSSRTPT KKFYFSKLPKPTGTPWAVGLSVYKGKAKGAAFVYINPQKR*" /label="yqgA CDS" gene complement(2111886..2112314) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /label="yqgA gene" promotor_-35 2112310..2112314 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-35" promotor_-10 2112324..2112338 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-10" upshifts 2112333 /Source="Nicolas_upshifts" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="upshifts" promotor_-10 complement(2112337..2112356) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-10" upshifts complement(2112360) /Source="Nicolas_upshifts" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="upshifts" promotor_-35 complement(2112371..2112378) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-35" promotor_-35 2112529..2112534 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2112550..2112568 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2112562 /Source="Nicolas_upshifts" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2112591..2112890 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15294815; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390385.1" /db_xref="EnsemblGenomes-Gn:BSU25060" /db_xref="EnsemblGenomes-Tr:CAB14436" /db_xref="GOA:P54483" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR020506" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11672" /db_xref="UniProtKB/Swiss-Prot:P54483" /translation="MKRLTLVCSIVFILFILFYDLKIGTIPIQDLPVYEASAKTAVQE PAYKTVKVKPGDTVMSIVGSAGSPDDIVKDFEALNPNVKANAIQAGTAYKFPVYP*" /label="yqfZ CDS" gene 2112591..2112890 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /label="yqfZ gene" promotor_-35 2112903..2112910 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2112925..2112944 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2112936..2113012 /Source="Nicolas_S_feature" /locus_tag="new_2589046_2589122" /HighExp="Diami, dia5, dia15, H2O2, Etha, Salt, LBGexp, Oxctl, Paraq, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="Sig-" /TUlongPSig=0 /label="S940" upshifts 2112936 /Source="Nicolas_upshifts" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2113013..2114146 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /EC_number="1.17.7.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12571359, 16268586, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase)" /protein_id="NP_390386.1" /db_xref="EnsemblGenomes-Gn:BSU25070" /db_xref="EnsemblGenomes-Tr:CAB14437" /db_xref="GOA:P54482" /db_xref="InterPro:IPR004588" /db_xref="InterPro:IPR011005" /db_xref="InterPro:IPR016425" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11671" /db_xref="UniProtKB/Swiss-Prot:P54482" /translation="MQVSEITHRTKTRPVKVGPLTIGGNNEVVIQSMTTTKTHDVEAT VAEINRLAEAGCQIVRVACPDERAANAIADIKKRISIPLVVDIHFDYKLALKAIEGGA DKIRINPGNIGRREKVEAVVKAAKDKGIPIRIGVNAGSLEKRILEKYGYPTADGMVES ALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAAKAFDYPLHLGITESGTLFAGTV KSAAGLGAILSKGIGNTMRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRI EIDLISIANEVEEYISKIKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGK IVRKVPEETMVEELKKEIDILAEEHYAKLEAEKAKLKEETQKA*" /label="ispG CDS" gene 2113013..2114146 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /label="ispG gene" downshifts 2114127 /Source="Nicolas_upshifts" /id="D1299" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.62035" /MaxDrop="8.92434" /score="30.8580926" /energy="-13.8" /TU="NA" /idTUdmin="U1948" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(2114172..2114561) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function expressed in germinating spores" /protein_id="NP_390387.1" /db_xref="EnsemblGenomes-Gn:BSU25080" /db_xref="EnsemblGenomes-Tr:CAB14438" /db_xref="GOA:P54481" /db_xref="SubtiList:BG11670" /db_xref="UniProtKB/Swiss-Prot:P54481" /translation="MKVANDYEKRDNNSYYVDHGSEGTNITRDNDGFFEETAAEIAEP YRAADRSNDQDNDRSGGNVNEGRGIGYIALALSIISLFVLPVLLGAAGIIVGYIARRR GAQGLGAWAMGIGVVSLVLGIFIIPFF*" /label="yqfX CDS" gene complement(2114172..2114561) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /label="yqfX gene" downshifts complement(2114198) /Source="Nicolas_upshifts" /id="D1300" /incds=0 /nref=10 /ntot=62 /MaxReadThrough="1.85077" /MaxDrop="8.74353" /score="28.1764525" /energy="-13.8" /TU="NA" /idTUdmin="U1950" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2114592..2114603) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2114596) /Source="Nicolas_upshifts" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2114617..2114623) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2114636..2114643 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2114654..2114673 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2114655 /Source="Nicolas_upshifts" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="upshifts" CDS 2114694..2115275 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotidase" /protein_id="NP_390388.1" /db_xref="EnsemblGenomes-Gn:BSU25090" /db_xref="EnsemblGenomes-Tr:CAB14439" /db_xref="GOA:P54480" /db_xref="InterPro:IPR009206" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11669" /db_xref="UniProtKB/Swiss-Prot:P54480" /translation="MLRLGIDIDGTITAQDTFVPYLNRSFNLSISLNDMTDYDLTKLL NITQEEFWDWMNQNEAIIYKEALLAQHAKQSLDLLKEEHKLIYITARRTHLTDITYEW FDRQNIHYDHIELVGGHHKVEAVKNHNIDLFFEDHHGNAMMIAKEAGIPVILFNSPYN QLPIDSNIIRVNNWLEAVQWMNNNKHHLIRVNN*" /label="yqfW CDS" gene 2114694..2115275 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /label="yqfW gene" downshifts 2115273 /Source="Nicolas_upshifts" /id="D1301" /incds=0 /nref=34 /ntot=240 /MaxReadThrough="4.07255" /MaxDrop="4.44714" /score="-2.90660182" /energy="-8" /TU="U1951" /idTUdmin="U1951" /TUdmin="-611" /isTUend="FALSE" /label="downshifts" S_feature 2115318..2115926 /Source="Nicolas_S_feature" /locus_tag="new_2591428_2592036" /HighExp="LoTm, S8, Cold, S7, S5, Sw, BC, S6, HiOs, B60" /AntisenseName="zur" /AntisenseCor="-0.265512398914523" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S941" CDS complement(2115318..2115755) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Zn[2+]-binding Fur family)" /protein_id="NP_390389.2" /db_xref="EnsemblGenomes-Gn:BSU25100" /db_xref="EnsemblGenomes-Tr:CAB14440" /db_xref="GOA:P54479" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11668" /db_xref="UniProtKB/Swiss-Prot:P54479" /translation="MNVQEALNLLKENGYKYTNKREDMLQLFADSDRYLTAKNVLSAL NDDYPGLSFDTIYRNLSLYEELGILETTELSGEKLFRFKCSFTHHHHHFICLACGKTK EIESCPMDKLCDDLDGYQVSGHKFEIYGTCPDCTAENQENTTA*" /label="zur CDS" gene complement(2115318..2115755) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /label="zur gene" downshifts complement(2115322) /Source="Nicolas_upshifts" /id="D1302" /incds=0 /nref=181 /ntot=243 /MaxReadThrough="2.37371" /MaxDrop="6.74703" /score="16.4418277" /energy="-11.9" /TU="U1956" /idTUdmin="U1952" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2115756..2115850) /Source="Nicolas_S_feature" /locus_tag="new_2591866_2591960_c" /HighExp="LPhT, G180, Cold, LBGstat, H2O2, Oxctl, G135, G150, HPh, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S942" promotor_-10 complement(2115846..2115865) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2115850) /Source="Nicolas_upshifts" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2115880..2115887) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2115893..2116774) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390390.2" /db_xref="EnsemblGenomes-Gn:BSU25110" /db_xref="EnsemblGenomes-Tr:CAB14441" /db_xref="GOA:P54478" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11667" /db_xref="UniProtKB/Swiss-Prot:P54478" /translation="MTPTKQHKKETFTHFIFRVFMILVGAASAAVSIELFLIPNDFID GGIIGVSLILDHLFMSNPFLNFAFFVVILNIPFMIFGYKYIGKTFLVSTFIGIVGLAV IESSLHHVEAITTQPILATVFGGLLLGFGVGLVIRNGGSMDGTEILGILLTKKLPFSV GEFVMFINVFIFIWAVFVFGPEQAMYSFMTYYIAMKTIDAVIQGLDETKAVIIVSEQY DEISDAILHRLGRGTTKLKGKGGYTDEEKDVIYAVVTRLEVTKLKSIVFEVDQNAFIT IMNTHETRGGKFKNAIH*" /label="yqfU CDS" gene complement(2115893..2116774) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /label="yqfU gene" promotor_-35 2116770..2116775 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2116791..2116809 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2116807 /Source="Nicolas_upshifts" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2116812..2116831) /Source="Nicolas_upshift_promotors" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2116818) /Source="Nicolas_upshifts" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2116820..2117147) /Source="Nicolas_S_feature" /locus_tag="new_2592930_2593257_c" /HighExp="Cold, T-4.40H, T-5.40H, Salt, GM-0.1, BMM, UNK1, MG 25, GM-0.2, SMM" /AntisenseName="yqfT" /AntisenseCor="-0.62379514374156597" /AntisenseRegPval="-29.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S943" promotor_-35 2116836..2116845 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2116852 /Source="Nicolas_upshifts" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2116858..2116877 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2116890..2117144 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390391.1" /db_xref="EnsemblGenomes-Gn:BSU25120" /db_xref="EnsemblGenomes-Tr:CAB14442" /db_xref="InterPro:IPR020277" /db_xref="SubtiList:BG11666" /db_xref="UniProtKB/Swiss-Prot:P54477" /translation="MILFQRIILQRLNQATADDLLKYSKQYGISLTRSQAVEVANLLY GKNVNIFNESERMRLLKQVETITSKETAQTVNELFKQFTS*" /label="yqfT CDS" gene 2116890..2117144 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /label="yqfT gene" downshifts 2117131 /Source="Nicolas_upshifts" /id="D1303" /incds=0 /nref=12 /ntot=72 /MaxReadThrough="3.97414" /MaxDrop="7.03976" /score="24.5413663" /energy="-9.8" /TU="U1953" /idTUdmin="U1955" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2117171..2118064) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /EC_number="3.1.21.2" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type IV apurinic/apyrimidinic endonuclease" /protein_id="NP_390392.1" /db_xref="EnsemblGenomes-Gn:BSU25130" /db_xref="EnsemblGenomes-Tr:CAB14443" /db_xref="GOA:P54476" /db_xref="InterPro:IPR001719" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR018246" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11665" /db_xref="UniProtKB/Swiss-Prot:P54476" /translation="MLRIGSHVSMSGKHMLLAASQEAVSYGANTFMIYTGAPQNTRRK KIEDLNIEAGRAHMQENGIDEIIVHAPYIINIGNTTNPSTFELGVDFLRSEIERTAAI GAKQIVLHPGAHVGAGAEAGIKKIIEGLNEVIDPNQNVQIALETMAGKGSECGRSFEE LAQIIEGVTHNEQLSVCFDTCHTHDAGYNIVEDFDGVLNEFDKIIGIDRIKVLHINDS KNVKGARKDRHENIGFGEIGFDALQYVVHHEQLKDIPKILETPYVGEDKKNKKPPYRF EIEMLKEKQFDDTLLEKILQQ*" /label="nfo CDS" gene complement(2117171..2118064) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /label="nfo gene" S_feature 2117176..2117977 /Source="Nicolas_S_feature" /locus_tag="new_2593286_2594087" /HighExp="S6, S7, C30, S8, S5, G135, C90, Gly, LoTm, Sw" /AntisenseName="nfo" /AntisenseCor="-0.36683479556464399" /AntisenseRegPval="-9.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S944" downshifts complement(2117192) /Source="Nicolas_upshifts" /id="D1304" /incds=0 /nref=46 /ntot=187 /MaxReadThrough="4.82641" /MaxDrop="6.05328" /score="16.7756411" /energy="-9.8" /TU="U1956" /idTUdmin="U1952" /TUdmin="-1870" /isTUend="FALSE" /label="downshifts" CDS complement(2118074..2119390) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 16352840, 18203828, 20572937, 23175651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16352840, 18203828, 20572937, 23175651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_390393.1" /db_xref="EnsemblGenomes-Gn:BSU25140" /db_xref="EnsemblGenomes-Tr:CAB14444" /db_xref="GOA:P54475" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030881" /db_xref="SubtiList:BG11664" /db_xref="UniProtKB/Swiss-Prot:P54475" /translation="MKETKFELYELKPFIIDAVHRLGFYEPTDIQKRLIPAVLKKESV IGQSQTGTGKTHAYLLPLLNKIDPAKDVVQVVITAPTRELANQIYQEALKITQGEEGS QIRSKCFIGGTDKQKSIDKLKIQPHLVVGTPGRIADLIKEQALSVHKAESLVIDEADL MLDMGFLADVDYIGSRMPEDLQMLVFSATIPEKLKPFLKKYMENPKYAHVEPKQVTAA KIEHILIPSKHRDKDKLLFDIMSHLNPYLGIVFANTKNTADHIAQYLTGKGMKIGLLH GGLTPRERKKVMKQINDLEFTYIIATDLAARGIDIKGVSHVINYELPDDLDFYVHRVG RTARAGSSGQAMTIYELTDEDALVRLEKMGIEFEYLELEKGEWKKGDDRQRRKKRKKT PNEADEIAHRLVKKPKKVKPGYKKKMSYEMEKIKKKQRRNQSKKRK*" /label="cshB CDS" gene complement(2118074..2119390) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /label="cshB gene" promotor_-10 complement(2119426..2119445) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2119437) /Source="Nicolas_upshifts" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2119461..2119465) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2119494..2119503 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2119515 /Source="Nicolas_upshifts" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2119517..2119536 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2119559..2120302 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390394.1" /db_xref="EnsemblGenomes-Gn:BSU25150" /db_xref="EnsemblGenomes-Tr:CAB14445" /db_xref="InterPro:IPR025571" /db_xref="SubtiList:BG11663" /db_xref="UniProtKB/Swiss-Prot:P54474" /translation="MFSPQQPMRNYPQPGPPRPMPNQRMMGRRPPNMRGPSFGAQQQG FQQAGQFLPQANAGARNGAGAGGGLKGMLSRFLPGGGGAGSAGVPGIPGAGAAASGGA GLQGIQNIANPASLSSMLGNVQKVLGMAQQVTPMIQQYGPLVRNLPAMMKLYSQLSKS DDTETEANEESEKQSVSEESSEKEKETETKTSDGNKKSKPKSSSLPKKSKTTDNKEQE LKTSAPKKKEAASPAPKRTSGSSKPRLYI*" /label="yqfQ CDS" gene 2119559..2120302 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /label="yqfQ gene" downshifts 2120284 /Source="Nicolas_upshifts" /id="D1305" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="5.46594" /MaxDrop="3.2445" /score="4.32537428" /energy="-6.8" /TU="U1957" /idTUdmin="U1957" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" promotor_-35 2120306..2120313 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2120327..2120346 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2120329..2120424 /Source="Nicolas_S_feature" /locus_tag="new_2596439_2596534" /HighExp="S8, S7, S6, Cold, H2O2, Salt, dia15, G180, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S945" upshifts 2120329 /Source="Nicolas_upshifts" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="upshifts" CDS 2120425..2121369 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /EC_number="1.17.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12706830, 15381396, 15469281, 17458547, 27169371; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase" /protein_id="NP_390395.2" /db_xref="EnsemblGenomes-Gn:BSU25160" /db_xref="EnsemblGenomes-Tr:CAB14446" /db_xref="GOA:P54473" /db_xref="InterPro:IPR003451" /db_xref="SubtiList:BG11662" /db_xref="UniProtKB/Swiss-Prot:P54473" /translation="MDVIKISPRGYCYGVVDAMVIAKNASLDKSLPRPIYILGMIVHN KHVTDAFEEEGIFTLDGSNRLDILKQVDKGTVIFTAHGVSPEVRRIAEEKGLVAIDAT CPDVTKTHNLILEMKEKGYHVIYIGKKGHPEPEGAVGVAPEIVHLVETEEDVKNLDIQ SEKLIVTNQTTMSQWDVHDIMELVKEKYPHVEYHQEICLATQVRQEAVSEQAKKADLT IVVGDPKSNNSNRLAQVSEEIAGTKAYRIGDLSELKLEWLKGVNTVAVTAGASTPTPI TKEVIRFLEQFDHEDPSTWTTEHNIPLKKILPKVKAKN*" /label="ispH CDS" gene 2120425..2121369 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /label="ispH gene" downshifts 2121340 /Source="Nicolas_upshifts" /id="D1306" /incds=0 /nref=106 /ntot=243 /MaxReadThrough="4.04288" /MaxDrop="5.66904" /score="29.529951" /energy="-12.2" /TU="U1958" /idTUdmin="U1957" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2121392..2122513) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17187687, 17586767; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative GTP cyclohydrolase" /protein_id="NP_390396.1" /db_xref="EnsemblGenomes-Gn:BSU25170" /db_xref="EnsemblGenomes-Tr:CAB14447" /db_xref="GOA:P54472" /db_xref="InterPro:IPR002678" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017221" /db_xref="InterPro:IPR036069" /db_xref="SubtiList:BG11661" /db_xref="UniProtKB/Swiss-Prot:P54472" /translation="MAKSVNGQQIIQLFEQFSPKAYAVEGDKIGLQIGTLNKPIKNVM VTLDVLESVIDEAIEKEVDLIIAHHPPIFRSLKHISTDQPAGRLIEKCLKHDIAVYAA HTNLDVADGGVNDLLAEALELSETEVLAPTYTDPLKKLAVYVPKEYEEQVRAALGNAG AGHIGEYSHCAFSSEGIGSFKPLDGAKPFIGEVGELELVHEVRLETVFPKSVEKAVIN AMIKSHPYEEVAYDIYPVEQTPAEKGLGRVGTLKNEMTLKEFALFVKDKLDVNGVRMV GDADSMVKKVAVLGGDGNKYIHHAKRKGADVYVTGDLYFHVAHDAMMLGLNVVDPGHY AEKIMKEGVTRKLTSMCNDKKFGVNIFVSETDTNPFTFL*" /label="yqfO CDS" gene complement(2121392..2122513) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /label="yqfO gene" downshifts complement(2121417) /Source="Nicolas_upshifts" /id="D1307" /incds=0 /nref=63 /ntot=224 /MaxReadThrough="3.241" /MaxDrop="4.76436" /score="27.9821938" /energy="-12.2" /TU="NA" /idTUdmin="U1959" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2122506..2123156) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /EC_number="2.1.1.217" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:18420655, 27098549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18420655, 27098549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (adenine(22)-N(1))-methyltransferase" /protein_id="NP_390397.1" /db_xref="EnsemblGenomes-Gn:BSU25180" /db_xref="EnsemblGenomes-Tr:CAB14448" /db_xref="GOA:P54471" /db_xref="InterPro:IPR006901" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11660" /db_xref="UniProtKB/Swiss-Prot:P54471" /translation="MADIGSDHAYLPCYAVLNHKASGAIAGEITDGPFLSAKRQVEKS GLNSHISVRQGDGLEVIKKGEADAITIAGMGGALIAHILEAGKDKLTGKERLILQPNI HAVHIREWLYKERYALIDEVILEEDGKCYEVLVAEAGDRDAAYDGISLSAGMLVGPFL AKEKNAVFLKKWTQELQHTQSIYEQISQAADTEQNKQKLKELADRMELLKEVIDHG*" /label="trmK CDS" gene complement(2122506..2123156) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /label="trmK gene" S_feature complement(2123157..2123265) /Source="Nicolas_S_feature" /locus_tag="new_2599267_2599375_c" /HighExp="LBGexp, LBGtran, dia15, dia0, Lbexp, G150, G180, LBGstat, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S946" promotor_-10 complement(2123253..2123272) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2123265) /Source="Nicolas_upshifts" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2123267..2123380) /Source="Nicolas_S_feature" /locus_tag="new_2599377_2599490_c" /HighExp="Lbstat, M0t90, M9-stat, S2, T1.0H, T1.30H, T2.30H, T3.0H, S7, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S947" promotor_-35 complement(2123288..2123292) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2123413..2123775) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10024472, 10473570, 11361075, 15995641, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024472, 10473570, 11361075, 15995641, 19222757; Product type c: carrier" /codon_start=1 /transl_table=11 /product="cytochrome c550" /protein_id="NP_390398.1" /db_xref="EnsemblGenomes-Gn:BSU25190" /db_xref="EnsemblGenomes-Tr:CAB14449" /db_xref="GOA:P24469" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10315" /db_xref="UniProtKB/Swiss-Prot:P24469" /translation="MKWNPLIPFLLIAVLGIGLTFFLSVKGLDDSREIASGGESKSAE KKDANASPEEIYKANCIACHGENYEGVSGPSLKGVGDKKDVAEIKTKIEKGGNGMPSG LVPADKLDDMAEWVSKIK*" /label="cccA CDS" gene complement(2123413..2123775) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /label="cccA gene" downshifts complement(2123425) /Source="Nicolas_upshifts" /id="D1308" /incds=0 /nref=3 /ntot=88 /MaxReadThrough="4.32389" /MaxDrop="3.4795" /score="-4.13120914" /energy="-7.6" /TU="U1961,U1962" /idTUdmin="U1968" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-35 2123771..2123775 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2123783..2123797 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2123804 /Source="Nicolas_upshifts" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2123812..2123831) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2123814) /Source="Nicolas_upshifts" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2123816..2123937) /Source="Nicolas_S_feature" /locus_tag="new_2599926_2600047_c" /HighExp="Lbstat, T3.0H, T1.30H, M9-stat, T2.30H, T1.0H, T2.0H, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S948" promotor_-35 complement(2123843..2123850) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2123926..2123945) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2123934..2123953 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2123937) /Source="Nicolas_upshifts" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2123939..2124078) /Source="Nicolas_S_feature" /locus_tag="new_2600049_2600188_c" /HighExp="Lbstat, S8, S1, S7, G/S, BT, Mal, Gly, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S949" S_feature 2123940..2124044 /Source="Nicolas_S_feature" /locus_tag="new_2600050_2600154" /HighExp="T2.30H, M9-stat, T3.0H, T1.30H, T2.0H, T1.0H, T3.30H, T4.0H, M0t90, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S950" upshifts 2123940 /Source="Nicolas_upshifts" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2123959..2123965) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2124008..2124015 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2124029..2124048 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2124046..2126195 /Source="Nicolas_S_feature" /locus_tag="new_2600156_2602305" /HighExp="S2, T4.0H, T5.0H, Lbstat, M9-stat, T3.30H, S8, T3.0H, C30, T2.0H" /AntisenseName="sigA" /AntisenseCor="-0.16938350693676901" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S951" upshifts 2124046 /Source="Nicolas_upshifts" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2124104..2125219) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12455702, 12682299, 14527287, 15060039, 15670950, 28648455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12455702, 12682299, 14527287, 15060039, 15670950, 28648455; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase major sigma-43 factor (sigma-A)" /protein_id="NP_390399.2" /db_xref="EnsemblGenomes-Gn:BSU25200" /db_xref="EnsemblGenomes-Tr:CAB14450" /db_xref="GOA:P06224" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007127" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR009042" /db_xref="InterPro:IPR012760" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR028630" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10314" /db_xref="UniProtKB/Swiss-Prot:P06224" /translation="MADKQTHETELTFDQVKEQLTESGKKRGVLTYEEIAERMSSFEI ESDQMDEYYEFLGEQGVELISENEETEDPNIQQLAKAEEEFDLNDLSVPPGVKINDPV RMYLKEIGRVNLLSAKEEIAYAQKIEEGDEESKRRLAEANLRLVVSIAKRYVGRGMLF LDLIQEGNMGLMKAVEKFDYRKGYKFSTYATWWIRQAITRAIADQARTIRIPVHMVET INKLIRVQRQLLQDLGREPTPEEIAEDMDLTPEKVREILKIAQEPVSLETPIGEEDDS HLGDFIEDQEATSPSDHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEE VGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE*" /label="sigA CDS" gene complement(2124104..2125219) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /label="sigA gene" downshifts complement(2124123) /Source="Nicolas_upshifts" /id="D1309" /incds=0 /nref=118 /ntot=198 /MaxReadThrough="4.93947" /MaxDrop="6.16048" /score="4.75833607" /energy="-11.7" /TU="U1966,U1968,U1969,U1970,U1972,U1973" /idTUdmin="U1970" /TUdmin="-287" /isTUend="FALSE" /label="downshifts" S_feature complement(2125220..2125417) /Source="Nicolas_S_feature" /locus_tag="new_2601330_2601527_c" /HighExp="BC, Cold, SMMPr, S1, BI, G135, C30, Lbstat, S5, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S952" CDS complement(2125418..2127229) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /EC_number="2.7.7.-" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3100394, 9387153, 12682299, 16036556, 28386108; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA primase" /protein_id="NP_390400.2" /db_xref="EnsemblGenomes-Gn:BSU25210" /db_xref="EnsemblGenomes-Tr:CAB14451" /db_xref="GOA:P05096" /db_xref="InterPro:IPR002694" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR006295" /db_xref="InterPro:IPR013264" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR019475" /db_xref="InterPro:IPR030846" /db_xref="InterPro:IPR034151" /db_xref="InterPro:IPR036185" /db_xref="InterPro:IPR036977" /db_xref="InterPro:IPR037068" /db_xref="PDB:5GUJ" /db_xref="SubtiList:BG10313" /db_xref="UniProtKB/Swiss-Prot:P05096" /translation="MGNRIPDEIVDQVQKSADIVEVIGDYVQLKKQGRNYFGLCPFHG ESTPSFSVSPDKQIFHCFGCGAGGNVFSFLRQMEGYSFAESVSHLADKYQIDFPDDIT VHSGARPESSGEQKMAEAHELLKKFYHHLLINTKEGQEALDYLLSRGFTKELINEFQI GYALDSWDFITKFLVKRGFSEAQMEKAGLLIRREDGSGYFDRFRNRVMFPIHDHHGAV VAFSGRALGSQQPKYMNSPETPLFHKSKLLYNFYKARLHIRKQERAVLFEGFADVISA VSSDVKESIATMGTSLTDDHVKILRRNVEEIILCYDSDKAGYEATLKASELLQKKGCK VRVAMIPDGLDPDDYIKKFGGEKFKNDIIDASVTVMAFKMQYFRKGKNLSDEGDRLAY IKDVLKEISTLSGSLEQEVYVKQLASEFSLSQESLTEQLSVFSKQNKPADNSGETKTR RAHLTTKARQKRLRPAYENAERLLLAHMLRDRSVIKKVIDRVGFQFNIDEHRALAAYL YAFYEEGAELTPQHLMARVTDDHISQLLSDILMLQVNQELSEAELSDYVKKVLNQRNW SMIKEKEAERAEAERQKDFLRAASLAQEIVTLNRSLK*" /label="dnaG CDS" gene complement(2125418..2127229) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /label="dnaG gene" promotor_-35 2126824..2126830 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2126840 /Source="Nicolas_upshifts" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2126842..2126861 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2126869..2127165 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 9864351" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_054587.1" /db_xref="EnsemblGenomes-Gn:BSU25220" /db_xref="EnsemblGenomes-Tr:CAE01462" /db_xref="GOA:Q7WY63" /db_xref="SubtiList:BG14178" /db_xref="UniProtKB/Swiss-Prot:Q7WY63" /translation="MPQPFFVLQKTLAGLRNGLLYHLENQFGICQQGEKPTRQKNSLP SALKKRKHCRPLRSQSNEKSVCRAIRKTKVCFLHEKDRVQSSFGLASLIEHNHL*" /label="antE CDS" gene 2126869..2127165 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /label="antE gene" CDS complement(2127263..2127757) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9387153, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390401.2" /db_xref="EnsemblGenomes-Gn:BSU25230" /db_xref="EnsemblGenomes-Tr:CAB14452" /db_xref="InterPro:IPR003791" /db_xref="SubtiList:BG10312" /db_xref="UniProtKB/Swiss-Prot:P17868" /translation="MEGWRITLLNEQEKTIFVDADACPVKDEILQTASEYEVQVLFVA SFEHYQLSRSNEEKWKYVDPHKEAADLYIANHVKPGDIVVTQDIGLASLLLNRNVSVM SERGRLYKEDTIDFALEGRHFSGKQRRKGVYAKGPKKLNKEDRERFITLLQKILSNDE GILH*" /label="yqxD CDS" gene complement(2127263..2127757) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /label="yqxD gene" promotor_-10 complement(2127730..2127748) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2127741) /Source="Nicolas_upshifts" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2127758..2127871) /Source="Nicolas_S_feature" /locus_tag="new_2603868_2603981_c" /HighExp="S5, S4, S6, S7, S8, S3, Etha, dia15, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S953" promotor_-35 complement(2127760..2127768) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-35 2127766..2127771 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2127787..2127805 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2127802 /Source="Nicolas_upshifts" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2127856..2127874) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2127871) /Source="Nicolas_upshifts" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2127873..2127950) /Source="Nicolas_S_feature" /locus_tag="new_2603983_2604060_c" /HighExp="Etha, G180, G135, G150, LBGtran, LBGexp, dia15, H2O2, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S954" promotor_-35 complement(2127890..2127895) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2127916..2127935) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2127950) /Source="Nicolas_upshifts" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2127951..2127954) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2128011..2128823) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 20044937" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 20044937; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional ADP-dependent kinase-Pi-dependent pyrophosphorylase / positive regulator of gluconeogenesis" /protein_id="NP_390402.1" /db_xref="EnsemblGenomes-Gn:BSU25240" /db_xref="EnsemblGenomes-Tr:CAB14453" /db_xref="GOA:P54470" /db_xref="InterPro:IPR005177" /db_xref="InterPro:IPR026565" /db_xref="SubtiList:BG11659" /db_xref="UniProtKB/Swiss-Prot:P54470" /translation="MNNRIIYVVSDSVGETAELVVKAALSQFNGSADDTHVRRIPYVE DIGTINEVISLAKADGGIICFTLVVPEIREYLIAEAEKANVLYYDIIGPLIDKMETAY GLTAKYEPGRVRQLDEDYFKKVEAIEFAVKYDDGRDPRGILKADIVLIGVSRTSKTPL SQYLAHKRLKVANVPIVPEVDPPEELFNVDPKKCIGLKISPDKLNHIRKERLKSLGLN DKAIYANINRIKEELEYFEKIVDRIGCQVVDVSNKAVEETANIIHHLKTKNI*" /label="ppsR CDS" gene complement(2128011..2128823) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /label="ppsR gene" CDS complement(2128849..2129487) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of gluconeogenesis" /protein_id="NP_390403.1" /db_xref="EnsemblGenomes-Gn:BSU25250" /db_xref="EnsemblGenomes-Tr:CAB14454" /db_xref="GOA:O34994" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016842" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3FV6" /db_xref="PDB:3FWR" /db_xref="PDB:3FWS" /db_xref="SubtiList:BG13768" /db_xref="UniProtKB/Swiss-Prot:O34994" /translation="MSTIELNKRQEHILQIVKENGPITGEHIAEKLNLTRATLRPDLA ILTMSGFLEARPRVGYFYTGKTGTQLLADKLKKLQVKDFQSIPVVIHENVSVYDAICT MFLEDVGTLFVVDRDAVLVGVLSRKDLLRASIGQQELTSVPVHIIMTRMPNITVCRRE DYVMDIAKHLIEKQIDALPVIKDTDKGFEVIGRVTKTNMTKILVSLSENEIL*" /label="ccpN CDS" gene complement(2128849..2129487) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /label="ccpN gene" S_feature complement(2129488..2129619) /Source="Nicolas_S_feature" /locus_tag="new_2605598_2605729_c" /HighExp="G135, dia5, G180, G150, dia15, H2O2, LBGexp, Lbexp, Oxctl, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999, 0.998" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S955" promotor_-10 complement(2129613..2129632) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" CDS complement(2129620..2131659) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (beta subunit)" /protein_id="NP_390404.2" /db_xref="EnsemblGenomes-Gn:BSU25260" /db_xref="EnsemblGenomes-Tr:CAB14455" /db_xref="GOA:P54381" /db_xref="InterPro:IPR006194" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR015944" /db_xref="SubtiList:BG11658" /db_xref="UniProtKB/Swiss-Prot:P54381" /translation="MSKQDLLLEIGLEEMPARFLNESMVQLGDKLTGWLKEKNITHGE VKLFNTPRRLAVFVKDVAEKQDDIKEEAKGPAKKIALDADGNWTKAAIGFSKGQGANV EDLYIKEVKGIEYVFVQKFQAGQETKSLLPELSGLITSLHFPKNMRWGNEDLRYIRPI KWIVALFGQDVIPFSITNVESGRTTQGHRFLGHEVSIESPSAYEEQLKGQHVIADPSV RKQMIQSQLETMAAENNWSIPVDEDLLDEVNHLVEYPTALYGSFESEFLSIPEEVLVT TMKEHQRYFPVKDKNGDLLPHFITVRNGNSHAIENVARGNEKVLRARLSDASFFYKED QKLNIDANVKKLENIVFHEELGSLADKVRRVTSIAEKLAVRLQADEDTLKHVKRAAEI SKFDLVTHMIYEFPELQGIMGEKYARMLGEDEAVAAAVNEHYMPRSAGGETPSTFTGA VVAMADKLDTIASFFSIGVIPTGSQDPYGLRRQASGIVAILLDRNWGISFEELLTFVQ TDKENELLDFFTQRLKYVLNAEQIRHDVIDAVLESSELEPYSALHKAQVLEQKLGAPG FKETAEALGRVISISKKGVRGDIQPDLFENEYEAKLFDAYQTAKQNLQENFSKKDYEA ALASLAALKEPIDAYFDHTMVIADNESLKANRLAQMVSLADEIKSFANMNALIVK*" /label="glyS CDS" gene complement(2129620..2131659) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /label="glyS gene" upshifts complement(2129622) /Source="Nicolas_upshifts" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2129647..2129654) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" downshifts complement(2129666) /Source="Nicolas_upshifts" /id="D1310" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="6.14024" /MaxDrop="3.62589" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" downshifts complement(2129732) /Source="Nicolas_upshifts" /id="D1311" /incds=1 /nref=10 /ntot=162 /MaxReadThrough="6.17154" /MaxDrop="3.30313" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1386" /isTUend="FALSE" /label="downshifts" CDS complement(2131652..2132539) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390405.1" /db_xref="EnsemblGenomes-Gn:BSU25270" /db_xref="EnsemblGenomes-Tr:CAB14456" /db_xref="GOA:P54380" /db_xref="InterPro:IPR002310" /db_xref="InterPro:IPR006194" /db_xref="SubtiList:BG11657" /db_xref="UniProtKB/Swiss-Prot:P54380" /translation="MNIQDMILTLQKHWSSQGCVLMQAYDVEKGAGTMSPYTFLRSIG PEPWKVAYVEPSRRPADGRYGENPNRLYQHHQFQVIIKPSPDNIQELYLDSLRALGID PLEHDIRFVEDNWENPSLGCAGLGWEVWLDGMEITQFTYFQQVGGLECKPVSVEITYG IERLASYIQDKENVFDLEWTSGFTVKDLFMMAEYEHSVYTFETSDVDMLFQLFSTYEK EAIKQMDNGLVHPAYDYVLKCSHTFNLLDAKGAISVTERTGYIARVRNLARKVAKTYY EEREKLGFPMLKGEGSSHE*" /label="glyQ CDS" gene complement(2131652..2132539) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /label="glyQ gene" misc_RNA complement(2132622..2132796) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /product="T-box riboswitch controlling synthesis of glycine-tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201, 15890195, 26229106" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201, 15890195, 26229106; Product type n : RNA" /label="tboG RNA" gene complement(2132622..2132796) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /label="tboG gene" downshifts complement(2132656) /Source="Nicolas_upshifts" /id="D1312" /incds=0 /nref=70 /ntot=220 /MaxReadThrough="6.60948" /MaxDrop="5.42847" /score="18.9025126" /energy="-23.3" /TU="U1972,U1973,U1975" /idTUdmin="U1976" /TUdmin=178 /isTUend="FALSE" /label="downshifts" promotor_-35 2132771..2132776 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2132792..2132810 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2132800..2132819) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" S_feature 2132802..2134214 /Source="Nicolas_S_feature" /locus_tag="new_2608912_2610324" /HighExp="C30, S8, Gly, BT, G135, Fru, S6, C90, Lbstat, Mal" /AntisenseName="recO" /AntisenseCor="0.22892689952134901" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S956" upshifts 2132802 /Source="Nicolas_upshifts" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2132812) /Source="Nicolas_upshifts" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2132834..2132841) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2132836..2133603) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10323239, 15186413, 16061691, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10323239, 15186413, 16061691, 26001966; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA double strand break repair and homologous recombination factor" /protein_id="NP_390406.2" /db_xref="EnsemblGenomes-Gn:BSU25280" /db_xref="EnsemblGenomes-Tr:CAB14457" /db_xref="GOA:P42095" /db_xref="InterPro:IPR003717" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022572" /db_xref="SubtiList:BG11189" /db_xref="UniProtKB/Swiss-Prot:P42095" /translation="MLTKCEGIVLRTNDYGETNKIVTLLTREHGKIGVMARGAKKPNS RLSAVSQPFLYGSFLMQKTSGLGTLQQGEMILSMRGIREDLFLTAYAAYVAELVDRGT EEKKPNPYLFEFILESLKQLNEGTDPDVITFIVQMKMLGVMGLYPELNHCVHCKSQDG TFHFSVRDNGFICHRCFEKDPYRIPIKPQTARLLRLFYYFDLSRLGNVSLKEETKAEL KQVIDLYYEEYSGLYLKSKRFLDQMESMKHLMGENKS*" /label="recO CDS" gene complement(2132836..2133603) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /label="recO gene" CDS complement(2133640..2133783) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097761.1" /db_xref="EnsemblGenomes-Gn:BSU25289" /db_xref="EnsemblGenomes-Tr:CAX52661" /db_xref="InterPro:IPR025617" /db_xref="UniProtKB/Swiss-Prot:C0H452" /translation="MLNFTWNVFSQTGNVDTYLLFKELEKENMERPEELEDELARFDY PIL*" /label="yqzL CDS" gene complement(2133640..2133783) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /label="yqzL gene" S_feature complement(2133784..2133930) /Source="Nicolas_S_feature" /locus_tag="new_2609894_2610040_c" /HighExp="Lbstat, T1.30H, T2.0H, M9-stat, S2, T3.0H, S5, M0t90, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.999, 0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S957" CDS complement(2133931..2134836) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maturation of 16S RNA and assembly of 30S ribosomal subunit GTPase" /protein_id="NP_390407.1" /db_xref="EnsemblGenomes-Gn:BSU25290" /db_xref="EnsemblGenomes-Tr:CAB14458" /db_xref="GOA:P42182" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005662" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030388" /db_xref="SubtiList:BG11188" /db_xref="UniProtKB/Swiss-Prot:P42182" /translation="MTNESFKSGFVSIIGRPNVGKSTFLNRVIGQKIAIMSDKPQTTR NKVQGVLTTGTSQTIFIDTPGIHKPKHKLGDFMMKVAQNTLKEVDLILFMINAEEGYG KGDEFIIEKLQTMSTPVFLIVNKIDKIHPDQLLLLIDEYRKRYPFKEIVPISALEGNN IETLLAQIEAYLPEGPQFYPSDQVTDHPERFIISELIREKVLHLTREEIPHSIAVAIE SIKGQDNGSVHVAATIVVERDSQKGIVIGKKGSLLKEVGKRARADIEALLGSRVYLEL WVKVQKDWRNKMSQLRDFGFKEDEY*" /label="era CDS" gene complement(2133931..2134836) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /label="era gene" CDS complement(2134817..2135227) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /EC_number="3.5.4.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2526291, 8157589, 10217788, 11851403, 22720735, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2526291, 8157589, 10217788, 11851403, 22720735, 25890046; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidine/deoxycytidine deaminase" /protein_id="NP_390408.1" /db_xref="EnsemblGenomes-Gn:BSU25300" /db_xref="EnsemblGenomes-Tr:CAB14459" /db_xref="GOA:P19079" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR006262" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1JTK" /db_xref="PDB:1UWZ" /db_xref="PDB:1UX0" /db_xref="PDB:1UX1" /db_xref="SubtiList:BG10477" /db_xref="UniProtKB/Swiss-Prot:P19079" /translation="MNRQELITEALKARDMAYAPYSKFQVGAALLTKDGKVYRGCNIE NAAYSMCNCAERTALFKAVSEGDTEFQMLAVAADTPGPVSPCGACRQVISELCTKDVI VVLTNLQGQIKEMTVEELLPGAFSSEDLHDERKL*" /label="cdd CDS" gene complement(2134817..2135227) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /label="cdd gene" promotor_-10 complement(2135265..2135284) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2135276) /Source="Nicolas_upshifts" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2135278..2135345) /Source="Nicolas_S_feature" /locus_tag="new_2611388_2611455_c" /HighExp="Oxctl, H2O2, G180, G150, GM 120, S1, G135, Diami, LBGtran, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S958" promotor_-35 complement(2135299..2135302) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2135346..2135717) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /EC_number="2.7.1.66" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12923107, 17535816, 19935659, 28872301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenol kinase" /protein_id="NP_390409.2" /db_xref="EnsemblGenomes-Gn:BSU25310" /db_xref="EnsemblGenomes-Tr:CAB14460" /db_xref="GOA:P19638" /db_xref="InterPro:IPR000829" /db_xref="InterPro:IPR033717" /db_xref="InterPro:IPR036945" /db_xref="SubtiList:BG11040" /db_xref="UniProtKB/Swiss-Prot:P19638" /translation="MDSKDHRNELNRFFKSFVHAGRGIWETARTERNFQFHAAAACAV LICGFLVELSIIEWMIIFLLIGGMFSLELLNTAIEHTVDLITDKHHPLAKAAKDAAAG AVCVFAVISCIIGLLIFLPKL*" /label="unpK CDS" gene complement(2135346..2135717) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /label="unpK gene" CDS complement(2135698..2136171) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16511207, 16818608, 19181801, 20639334, 20807199, 23273979, 23638028, 24511998, 24901994, 28031281; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease involved in 70S ribosomes quality control" /protein_id="NP_390410.2" /db_xref="EnsemblGenomes-Gn:BSU25320" /db_xref="EnsemblGenomes-Tr:CAB14461" /db_xref="GOA:P46347" /db_xref="InterPro:IPR002036" /db_xref="InterPro:IPR020549" /db_xref="InterPro:IPR023091" /db_xref="SubtiList:BG11656" /db_xref="UniProtKB/Swiss-Prot:P46347" /translation="MSLLIDIVDETGSVSEEMLKEVENLLQFAAEREGVQDQAEVSVT IVSNDDIHQINKEYRGKDAPTDVISFALEEEGEGEIEIVGAEMPPVLGDIIISADRTR EQAEEYNHSFKRELGFLAVHGFLHLLGYDHMTKEEEEEMFTKQKELLDAYGLKRS*" /label="rnrY CDS" gene complement(2135698..2136171) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /label="rnrY gene" CDS complement(2136172..2138307) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751502, 26240071, 27378384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751502, 26240071, 27378384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="c-di-AMP-degrading phosphodiesterases" /protein_id="NP_390411.1" /db_xref="EnsemblGenomes-Gn:BSU25330" /db_xref="EnsemblGenomes-Tr:CAB14462" /db_xref="GOA:P46344" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR011621" /db_xref="InterPro:IPR011624" /db_xref="SubtiList:BG11655" /db_xref="UniProtKB/Swiss-Prot:P46344" /translation="MLKKKAKTKSSSKKWSSFKNARSMHVLLYLLLAAIMFALLFVHV KPETLDLDLFSVSDKTIYAPATVEDQKATEEKKQAAEDAVEDQYTLKKEYTDNRIDLV SSIFDSISEVKKSSEEGSKSPSEKSMVKSVKDKLTSDVNDSISEDSIKTLLKADSEDF SFVRDTVITAVNTVMSSEIPSDKLSDAKDKVEKELKSNSIPSKYLGAATEIGRFAIIP NYVFDPKATEAKRQEASDNVQQVQIKQGQVLVEENDLIDREVYRKLELTGLLNNSNLF KPISGLLIMIGLFIATLVYYFEKQKQNLKFKNQSILLFSIITTLLLVIMEVVSLFQKM EYNNIGYLVPIAAGAILIKLLMNERIAILGSIILAICGSMMFNQGVTGTFNYVIGIYY LISGISGVLFLGKHNARSKILQTGLFVAFINMVVVLSLLLIQNTALSGLEIGTLMLMG VVSGFASSVLIIGLMPFFETGFGILSTMRLLELSNPNHPLLRKILTETPGTYHHSVMV ANLSEAACEAVGANGLLARVGAYYHDLGKTKRPQYFIENQMNIDNPHDKLSPQLSKNI IISHTTDGANMLRSYKFPKELVDIAEQHHGTSLLKFFYYKAKEKGDQITEEEFRYPGP KPQSKEAAIISVADSVEAAVRSMHNPNPERIEKLVRGIISDKLQDGQFSECDLTFKEL DTIAKTLCATLKGIFHSRIEYPEATKKVK*" /label="pgpH CDS" gene complement(2136172..2138307) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /label="pgpH gene" promotor_-35 2138151..2138156 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2138171 /Source="Nicolas_upshifts" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2138172..2138190 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2138386..2139345) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12762842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12762842; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="phosphate starvation-induced protein" /protein_id="NP_390412.2" /db_xref="EnsemblGenomes-Gn:BSU25340" /db_xref="EnsemblGenomes-Tr:CAB14476" /db_xref="GOA:P46343" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11337" /db_xref="UniProtKB/Swiss-Prot:P46343" /translation="MTEHLLAMNQKLKNPDEALSLFGNQDSFLKLMEKDLNLNIITRG ETIYVSGDDESFQIADRLLGSLLALIRKGIEISERDVIYAIKMAKKNELEYFESMYEE EITKNAKGKSIRVKTMGQREYVAAMKRNDLVFGIGPAGTGKTYLAVVKAVHALKNGHI KKIILTRPAVEAGESLGFLPGDLKEKVDPYLRPLYDALHDVLGADHTERLMERGIIEI APLAYMRGRTLDDAYVILDEAQNTTPAQMKMFLTRLGFGSKMIITGDVSQIDLPKGVK SGLAVAKEMLKGIDGISMIELDQTDVVRHPLVAKIIEAYDKQN*" /label="phoH CDS" gene complement(2138386..2139345) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /label="phoH gene" downshifts complement(2138401) /Source="Nicolas_upshifts" /id="D1313" /incds=0 /nref=1 /ntot=63 /MaxReadThrough="6.04676" /MaxDrop="4.50442" /score="9.12152318" /energy="-13.1" /TU="U1975,U1976,U1977" /idTUdmin="U1978" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" CDS complement(2139342..2140538) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14523133, 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage IV sporulation protein; putative UDP-glucose-4-epimerase" /protein_id="NP_390413.2" /db_xref="EnsemblGenomes-Gn:BSU25350" /db_xref="EnsemblGenomes-Tr:CAB14477" /db_xref="GOA:P54469" /db_xref="InterPro:IPR010690" /db_xref="SubtiList:BG11654" /db_xref="UniProtKB/Swiss-Prot:P54469" /translation="MKNKWLSFFSGKVQLELTGRGIERLLNECTRQGIPVFHVKKKKE AVSLYIQLQDVHAFRRVRSKFKCKARFINRKGFPFLLLKSKLNIGFTIGFAIFFILLF LLSNMVWKIDVTGAKPETEHQMRQHLNEIGVKKGRLQFLMMSPEKIQKSLTNGIDNIT WVGVDLKGTTIHMKVVEKNEPEKEKYVSPRNIVAKKKATITRMFVQKGQPMAAIHDHV EKGQLLVSGLIGSEDHQQEVASKAEIYGETWYRSEVTVPLETLFNVYTGKVRTKHKLS FGSLAIPIWGMTFKKEELKHPKTEQEKHSLHFLGFKLPVSYVKEQTRESEEALRKYTK EEAVQEGIKLGKQDVEDKIGENGEVKSEKVLHQTVENGKVKLIILYQVIEDIVQTTPI VRETEE*" /label="yqfD CDS" gene complement(2139342..2140538) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /label="yqfD gene" promotor_-10 complement(2139409..2139428) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2139414) /Source="Nicolas_upshifts" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2139442..2139449) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2139489..2139507) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-10" upshifts complement(2139501) /Source="Nicolas_upshifts" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="upshifts" promotor_-35 complement(2139522..2139528) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-35" upshifts complement(2139716) /Source="Nicolas_upshifts" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="upshifts" promotor_-10 complement(2139730..2139741) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-10" promotor_-35 complement(2139756..2139762) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-35" CDS complement(2140557..2140838) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12662922" /codon_start=1 /transl_table=11 /product="conserved sporulation protein of unknown function" /protein_id="NP_390414.1" /db_xref="EnsemblGenomes-Gn:BSU25360" /db_xref="EnsemblGenomes-Tr:CAB14478" /db_xref="InterPro:IPR022476" /db_xref="InterPro:IPR022477" /db_xref="SubtiList:BG11653" /db_xref="UniProtKB/Swiss-Prot:P54468" /translation="MGQRKNRMKAWLTRALEIPPDVMMDLPRITMVGRLHIYIENHRG LLLFSENEVRLMLKQGQCIISGKNFVIKAILPEEILLEGTIDVVRYVES*" /label="yqfC CDS" gene complement(2140557..2140838) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /label="yqfC gene" CDS complement(2140895..2141314) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390415.2" /db_xref="EnsemblGenomes-Gn:BSU25370" /db_xref="EnsemblGenomes-Tr:CAB14479" /db_xref="GOA:P54467" /db_xref="InterPro:IPR016788" /db_xref="SubtiList:BG11652" /db_xref="UniProtKB/Swiss-Prot:P54467" /translation="MEDLLTNPLIIAAIIGIISAIFGKKSKEEKQNSQKRKKPQHVQS ASPQKKQSKEDAPAPIPNRMEQARREAEERRRETARNLKGLERDLAAAKQKTVYTKQK MLQVNKDTVVQGIVLGEVFGPPRAKKPHRTMRPARKN*" /label="yqfB CDS" gene complement(2140895..2141314) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /label="yqfB gene" downshifts complement(2140909) /Source="Nicolas_upshifts" /id="D1314" /incds=0 /nref=232 /ntot=257 /MaxReadThrough="4.55662" /MaxDrop="7.47609" /score="-3.87904232" /energy="-16.8" /TU="U1978" /idTUdmin="U1980" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2141339..2142334) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12501411, 22753055" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12501411, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="flotillin-like protein involved in membrane lipid rafts" /protein_id="NP_390416.1" /db_xref="EnsemblGenomes-Gn:BSU25380" /db_xref="EnsemblGenomes-Tr:CAB14480" /db_xref="GOA:P54466" /db_xref="InterPro:IPR022853" /db_xref="SubtiList:BG11651" /db_xref="UniProtKB/Swiss-Prot:P54466" /translation="MDPSTLMILAIVAVAIIVLAVFFTFVPVMLWISALAAGVKISIF TLVGMRLRRVIPNRVVNPLIKAHKAGLNVGTNQLESHYLAGGNVDRVVNALIAAQRAN IELTFERCAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMDGIEVKAKARITVRANI ERLVGGAGEETIVARVGEGIVSTIGSSDNHKKVLENPDMISQTVLGKGLDSGTAFEIL SIDIADVDIGKNIGAILQTDQAEADKNIAQAKAEERRAMAVAQEQEMRARVEEMRAKV VEAEAEVPLAMAEALREGNIGVMDYMNIKNIDADTEMRDSFGKLTKDPSDEDRKS*" /label="floA CDS" gene complement(2141339..2142334) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /label="floA gene" CDS complement(2142356..2143669) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22753055; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound peptidase of unkwnown function" /protein_id="NP_390417.1" /db_xref="EnsemblGenomes-Gn:BSU25390" /db_xref="EnsemblGenomes-Tr:CAB14481" /db_xref="GOA:P54465" /db_xref="InterPro:IPR002810" /db_xref="InterPro:IPR002825" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11650" /db_xref="UniProtKB/Swiss-Prot:P54465" /translation="MLQIKGFRAALLGIFLLSLLGVQLNAKAEKQTVYVIPVEKNVEQ GLASFLSRSLQDAKDAHADHIILDINTPGGLVKSAIDMADLITESEIPVTAYVNKRAL SAGAYIALQADHIYMAPGGKMGAAAIVDGQGNAADQKAQSLWLAEMEDAAVKNNRDPK YALAMADPDIDAKEVGAPKGDLLTLNADKAIEVGYSEGTADNLSTLVKKLGFEKAQIS YAKESFAEKTARWLTNPVIVPILLTIAFLGLTVELFSPGVGLPGTAGLIALLLFFYGH LAAGLAGYETVLLFIAGVILILLEIFLPGGIIGLLGLGAIIASLFLAAGSFTVMAVSL LIASAVSITAFILLTRVLGKRMKFFKKLILNDSTNTESGYVSNQTRTDLMGKVGITFT PLRPSGTVIIDDERLDVVSEGSFTEKDKKVKVIKVEGSRIVVREI*" /label="nfeDA CDS" gene complement(2142356..2143669) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /label="nfeDA gene" promotor_-10 complement(2143705..2143720) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-10" upshifts complement(2143722) /Source="Nicolas_upshifts" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="upshifts" promotor_-35 complement(2143733..2143742) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-35" CDS complement(2143800..2144246) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17284460, 22720735, 25149203" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function with tRNA aminoacid amidase domain" /protein_id="NP_390418.1" /db_xref="EnsemblGenomes-Gn:BSU25400" /db_xref="EnsemblGenomes-Tr:CAB14482" /db_xref="GOA:P54464" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR019004" /db_xref="InterPro:IPR023168" /db_xref="PDB:1NG6" /db_xref="SubtiList:BG11649" /db_xref="UniProtKB/Swiss-Prot:P54464" /translation="MSLLERLNQDMKLYMKNREKDKLTVVRMVKASLQNEAIKLKKDS LTEDEELTVLSRELKQRKDSLQEFSNANRLDLVDKVQKELDILEVYLPEQLSEEELRT IVNETIAEVGASSKADMGKVMGAIMPKVKGKADGSLINKLVSSQLS*" /label="yqeY CDS" gene complement(2143800..2144246) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /label="yqeY gene" downshifts complement(2143813) /Source="Nicolas_upshifts" /id="D1315" /incds=0 /nref=248 /ntot=267 /MaxReadThrough="5.1355" /MaxDrop="8.31948" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" downshifts complement(2144011) /Source="Nicolas_upshifts" /id="D1316" /incds=1 /nref=1 /ntot=34 /MaxReadThrough="8.99916" /MaxDrop="1.9798" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(2144261..2144434) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 22720735, 23002217, 25035996" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 22720735, 23002217, 25035996; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S21" /protein_id="NP_390419.1" /db_xref="EnsemblGenomes-Gn:BSU25410" /db_xref="EnsemblGenomes-Tr:CAB14483" /db_xref="GOA:P21478" /db_xref="InterPro:IPR001911" /db_xref="InterPro:IPR018278" /db_xref="SubtiList:BG11648" /db_xref="UniProtKB/Swiss-Prot:P21478" /translation="MSKTVVRKNESLEDALRRFKRSVSKTGTLQEARKREFYEKPSVK RKKKSEAARKRKF*" /label="rpsU CDS" gene complement(2144261..2144434) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /label="rpsU gene" misc_feature 2144370..2144374 /Source="Nicolas_upshift_promotors" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2144375 /Source="Nicolas_upshifts" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2144495..2144514) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2144510) /Source="Nicolas_upshifts" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2144528..2144535) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2144553..2144558 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2144573 /Source="Nicolas_upshifts" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2144574..2144592 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2144607..2145530 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/anion cotransporter" /protein_id="NP_390420.2" /db_xref="EnsemblGenomes-Gn:BSU25420" /db_xref="EnsemblGenomes-Tr:CAB14484" /db_xref="GOA:P54463" /db_xref="InterPro:IPR003841" /db_xref="InterPro:IPR004633" /db_xref="SubtiList:BG11647" /db_xref="UniProtKB/Swiss-Prot:P54463" /translation="MLILISFTALILFFLAGMNMLRKGLISMAYSKIEERLLLFTDHP LKAFLISIVFTGILQSSSAFMVIVIGFVSAGVLSFKRTIPMILGTNVGSTFTTEFIAI KMDIVIWVLLIGGLLFFLTGRYPLKQLGTSFLGLGIIFFCISGFSHLAGPLTKLKTGA DVLYHVNDSNWSALLIGMVLTAIIHSSSVCIGILMSFMNEGIIGLTQAMSVVLGSNIG TCITAVMAAVSGGYAAKQTAYAHVVFNVLGVALVLPFLTAATGFVEQLSPDPAQKIAH FSLLFNVVTALLFLPLTNLFYRLIHLLIPAK*" /label="yqeW CDS" gene 2144607..2145530 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /label="yqeW gene" CDS complement(2145567..2146922) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA N(6)-threonylcarbamoyladenosine (t(6)A) methylthiotransferase" /protein_id="NP_390421.1" /db_xref="EnsemblGenomes-Gn:BSU25430" /db_xref="EnsemblGenomes-Tr:CAB14485" /db_xref="GOA:P54462" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006467" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR034557" /db_xref="SubtiList:BG11646" /db_xref="UniProtKB/Swiss-Prot:P54462" /translation="MATVAFHTLGCKVNHYETEAIWQLFKEAGYERRDFEQTADVYVI NTCTVTNTGDKKSRQVIRRAIRQNPDGVICVTGCYAQTSPAEIMAIPGVDIVVGTQDR EKMLGYIDQYREERQPINGVSNIMKARVYEELDVPAFTDRTRASLKIQEGCNNFCTFC IIPWARGLLRSRDPEEVIKQAQQLVDAGYKEIVLTGIHTGGYGEDMKDYNFAKLLSEL DTRVEGVKRIRISSIEASQITDEVIEVLDRSDKIVNHLHIPIQSGSNTVLKRMRRKYT MEFFADRLNKLKKALPGLAVTSDVIVGFPGETEEEFMETYNFIKEHKFSELHVFPYSK RTGTPAARMEDQVDENVKNERVHRLIALSDQLAKEYASQYENEVLEIIPEEAFKETEE ENMFVGYTDNYMKVVFKGTEDMIGKIVKVKILKAGYPYNEGQFVRVVEDEITEHMRLS S*" /label="mtaB CDS" gene complement(2145567..2146922) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /label="mtaB gene" downshifts complement(2145573) /Source="Nicolas_upshifts" /id="D1317" /incds=0 /nref=208 /ntot=260 /MaxReadThrough="1.95578" /MaxDrop="6.05381" /score="30.7201786" /energy="-11.3" /TU="NA" /idTUdmin="U1983" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2146922..2147692) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /EC_number="2.1.1.193" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9023197, 10383760, 14517985, 16014871, 16431987, 22925577, 24598751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylase of U1498 in 16S rRNA" /protein_id="NP_390422.1" /db_xref="EnsemblGenomes-Gn:BSU25440" /db_xref="EnsemblGenomes-Tr:CAB14486" /db_xref="GOA:P54461" /db_xref="InterPro:IPR006700" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1VHK" /db_xref="SubtiList:BG11645" /db_xref="UniProtKB/Swiss-Prot:P54461" /translation="MQRYFIELTKQQIEEAPTFSITGEEVHHIVNVMRMNEGDQIICC SQDGFEAKCELQSVSKDKVSCLVIEWTNENRELPIKVYIASGLPKGDKLEWIIQKGTE LGAHAFIPFQAARSVVKLDDKKAKKKRERWTKIAKEAAEQSYRNEVPRVMDVHSFQQL LQRMQDFDKCVVAYEESSKQGEISAFSAIVSSLPKGSSLLIVFGPEGGLTEAEVERLT EQDGVTCGLGPRILRTETAPLYALSAISYQTELLRGDQ*" /label="rsmE CDS" gene complement(2146922..2147692) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /label="rsmE gene" CDS complement(2147715..2148650) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17215866, 18611379; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 methyltransferase" /protein_id="NP_390423.2" /db_xref="EnsemblGenomes-Gn:BSU25450" /db_xref="EnsemblGenomes-Tr:CAB14487" /db_xref="GOA:P54460" /db_xref="InterPro:IPR004498" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11644" /db_xref="UniProtKB/Swiss-Prot:P54460" /translation="MKWSELSIHTTHEAVEPISNILHEAGASGVVIEDPLDLIKEREN VYGEIYQLDPNDYPDEGVIVKAYLPVNSFLGETVDGIKETINNLLLYNIDLGRNHITI SEVNEEEWATAWKKYYHPVKISEKFTIVPTWEEYTPVHTDELIIEMDPGMAFGTGTHP TTVLCIQALERFVQKGDKVIDVGTGSGILSIAAAMLEAESVHAYDLDPVAVESARLNL KLNKVSDIAQVKQNNLLDGIEGEHDVIVANILAEVILRFTSQAYSLLKEGGHFITSGI IGHKKQEVKEALEQAGFTIVEILSMEDWVSIIAKK*" /label="prmA CDS" gene complement(2147715..2148650) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /label="prmA gene" CDS complement(2148675..2149802) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10383760, 10658654, 16385044, 16952052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10383760, 10658654, 16385044, 16952052; Product type f: factor" /codon_start=1 /transl_table=11 /product="co-factor of molecular chaperone" /protein_id="NP_390424.2" /db_xref="EnsemblGenomes-Gn:BSU25460" /db_xref="EnsemblGenomes-Tr:CAB14488" /db_xref="GOA:P17631" /db_xref="InterPro:IPR001305" /db_xref="InterPro:IPR001623" /db_xref="InterPro:IPR002939" /db_xref="InterPro:IPR008971" /db_xref="InterPro:IPR012724" /db_xref="InterPro:IPR018253" /db_xref="InterPro:IPR036410" /db_xref="InterPro:IPR036869" /db_xref="SubtiList:BG10665" /db_xref="UniProtKB/Swiss-Prot:P17631" /translation="MSKRDYYEVLGVSKSASKDEIKKAYRKLSKKYHPDINKEAGSDE KFKEVKEAYETLSDDQKRAHYDQFGHTDPNQGFGGGGFGGGDFGGFGFDDIFSSIFGG GTRRRDPNAPRQGADLQYTMTLSFEDAAFGKETTIEIPREETCETCKGSGAKPGTNPE TCSHCGGSGQLNVEQNTPFGKVVNRRVCHHCEGTGKIIKNKCADCGGKGKIKKRKKIN VTIPAGVDDGQQLRLSGQGEPGINGGPAGDLFVVFHVRAHEFFERDGDDIYCEMPLTF AQAALGDEVEVPTLHGKVKLKIPAGTQTGTKFRLRGKGVQNVRGYGQGDQHIVVRVVT PTNLTDKQKDIIREFAEVSGNLPDEQEMSFFDKVKRAFKGD*" /label="dnaJ CDS" gene complement(2148675..2149802) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /label="dnaJ gene" misc_feature 2149719..2149722 /Source="Nicolas_upshift_promotors" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2149730 /Source="Nicolas_upshifts" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2149803..2149980) /Source="Nicolas_S_feature" /locus_tag="new_2625913_2626090_c" /HighExp="Heat, dia15, H2O2, Diami, G135, G150, G180, LPhT, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.357489" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S959" misc_RNA 2149842..2149932 /gene="surC" /locus_tag="BSU_misc_RNA_79" /product="sporulation-related small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surC RNA" gene 2149842..2149932 /gene="surC" /locus_tag="BSU_misc_RNA_79" /label="surC gene" CDS complement(2150002..2151837) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular chaperone, ATP-dependent" /protein_id="NP_390425.1" /db_xref="EnsemblGenomes-Gn:BSU25470" /db_xref="EnsemblGenomes-Tr:CAB14489" /db_xref="GOA:P17820" /db_xref="InterPro:IPR012725" /db_xref="InterPro:IPR013126" /db_xref="InterPro:IPR018181" /db_xref="InterPro:IPR029047" /db_xref="InterPro:IPR029048" /db_xref="PDB:2FZO" /db_xref="SubtiList:BG10664" /db_xref="UniProtKB/Swiss-Prot:P17820" /translation="MSKVIGIDLGTTNSCVAVLEGGEPKVIANAEGNRTTPSVVAFKN GERQVGEVAKRQSITNPNTIMSIKRHMGTDYKVEIEGKDYTPQEVSAIILQHLKSYAE SYLGETVSKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDE DQTILVYDLGGGTFDVSILELGDGVFEVRSTAGDNRLGGDDFDQVIIDHLVSEFKKEN GIDLSKDKMALQRLKDAAEKAKKDLSGVSSTQISLPFITAGEAGPLHLELTLTRAKFE ELSSHLVERTMGPVRQALQDAGLSASEIDKVILVGGSTRIPAVQEAIKKETGKEAHKG VNPDEVVALGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK SQVFSTAADNQTAVDIHVLQGERPMSADNKTLGRFQLTDIPPAPRGVPQIEVSFDIDK NGIVNVRAKDLGTGKEQNITIKSSSGLSDEEIERMVKEAEENADADAKKKEEIEVRNE ADQLVFQTEKTLKDLEGKVDEEQVKKANDAKDALKAAIEKNEFEEIKAKKDELQTIVQ ELSMKLYEEAAKAQQAQGGANAEGKADDNVVDAEYEEVNDDQNKK*" /label="dnaK CDS" gene complement(2150002..2151837) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /label="dnaK gene" downshifts complement(2150025) /Source="Nicolas_upshifts" /id="D1318" /incds=0 /nref=130 /ntot=247 /MaxReadThrough="8.0737" /MaxDrop="4.023" /score="21.9400858" /energy="-13.4" /TU="U1983,U1985" /idTUdmin="U1984" /TUdmin=3565 /isTUend="FALSE" /label="downshifts" CDS complement(2151861..2152424) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nucleotide exchange factor for DnaK activity" /protein_id="NP_390426.1" /db_xref="EnsemblGenomes-Gn:BSU25480" /db_xref="EnsemblGenomes-Tr:CAB14490" /db_xref="GOA:P15874" /db_xref="InterPro:IPR000740" /db_xref="InterPro:IPR009012" /db_xref="InterPro:IPR013805" /db_xref="PDB:2G61" /db_xref="SubtiList:BG10663" /db_xref="UniProtKB/Swiss-Prot:P15874" /translation="MSEEKQTVEQNETEEQEIIEEQAAADEQQEETNESELLQNQINE LQGLLEEKENKLLRVQADFENYKRRSRLEMEASQKYRSQNIVTDLLPALDSFERALQV EADNEQTKSLLQGMEMVHRQLVEALKKEGVEAIEAVGQEFDPNLHQAVMQAEDENYGS NIVVEEMQKGYKLKDRVIRPSMVKVNQ*" /label="grpE CDS" gene complement(2151861..2152424) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /label="grpE gene" S_feature complement(2152425..2152495) /Source="Nicolas_S_feature" /locus_tag="new_2628535_2628605_c" /HighExp="LPhT, dia15, Heat, Etha, Diami, dia5, H2O2, T-0.40H, T0.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S960" CDS complement(2152496..2153527) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10555317, 12082092, 15109714, 16872404, 16585746, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10555317, 12082092, 15109714, 16872404, 16585746, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of heat-shock genes" /protein_id="NP_390427.1" /db_xref="EnsemblGenomes-Gn:BSU25490" /db_xref="EnsemblGenomes-Tr:CAB14491" /db_xref="GOA:P25499" /db_xref="InterPro:IPR002571" /db_xref="InterPro:IPR021153" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10662" /db_xref="UniProtKB/Swiss-Prot:P25499" /translation="MLTNRQLLILQVIINDFIKSAQPVGSRTLSKKDEITFSSATIRN EMADLEELGFIEKTHSSSGRVPSEKGYRYYVDHLLSPVKLTKSDLDQIHSIFKEKIFE LEKTVQKSAQILSDLTNYTSIVLGPKLSENYLKQIQIIPIQPDMAVAILVTNTGHVEN KTINFPTKMDLSDIEKLVNILNDRLSGVPMDELNERIFKEVVMYLRQHIKNYDNILDA LRSTFHSTNHVEKLFFGGKINMLNQPEFHDITRVRSLLSLIEKEQDVLKLVQSPHTGI SIKIGKENDYEEMENCSLITASYSVDQKQIGSIAIIGPTRMNYSRVVSLLQHVTSDLS KALTSLYDE*" /label="hrcA CDS" gene complement(2152496..2153527) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /label="hrcA gene" promotor_-10 complement(2153568..2153587) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2153581) /Source="Nicolas_upshifts" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2153602..2153609) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2153608..2154747) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /EC_number="1.3.98.3" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8757728, 9371469, 10498703, 12196143, 19944166" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8757728, 9371469, 10498703, 12196143, 19944166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_390428.2" /db_xref="EnsemblGenomes-Gn:BSU25500" /db_xref="EnsemblGenomes-Tr:CAB14492" /db_xref="GOA:P54304" /db_xref="InterPro:IPR004559" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010723" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG11395" /db_xref="UniProtKB/Swiss-Prot:P54304" /translation="MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNALEQEMINT IAKTGQPDLKTIFIGGGTPTSLSEEQLKKLMDMINRVLKPSSDLSEFAVEANPDDLSA EKLKILKEAGVNRLSFGVQTFEDDLLEKIGRVHKQKDVFTSFERAREIGFENISLDLM FGLPGQTLKHLEHSINTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPPQEQEAE MYEIVMSKMEAHGIHQYEISNFAKAGMESKHNLTYWSNEQYFGFGAGAHGYIGGTRTV NVGPVKHYIDLIAEKGFPYRDTHEVTTEEQIEEEMFLGLRKTAGVSKKRFAEKYGRSL DGLFPSVLKDLAEKGLIHNSESAVYLTHQGKLLGNEVFGAFLGEL*" /label="hemN CDS" gene complement(2153608..2154747) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /label="hemN gene" promotor_-10 complement(2154620..2154631) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-10" upshifts complement(2154624) /Source="Nicolas_upshifts" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="upshifts" promotor_-35 complement(2154645..2154651) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-35" CDS complement(2154800..2156638) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12511492, 17110332, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal elongation factor, GTPase" /protein_id="NP_390429.1" /db_xref="EnsemblGenomes-Gn:BSU25510" /db_xref="EnsemblGenomes-Tr:CAB14493" /db_xref="GOA:P37949" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006297" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR013842" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035654" /db_xref="SubtiList:BG10441" /db_xref="UniProtKB/Swiss-Prot:P37949" /translation="MTDKEKRLERQSRIRNFSIIAHIDHGKSTLADRILEKTSAITQR EMKEQLLDSMDLERERGITIKLNSVQLKYKAKDGEEYIFHLIDTPGHVDFTYEVSRSL AACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPSAEPERVRQEVEDV IGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDPEAPLKALIFDSLYDAYRGVVA YIRVVEGTVKPGQKIKMMATGKEFEVTEVGVFTPKATPTNELTVGDVGFLTASIKNVG DTRVGDTITSAANPAEEALPGYRKLNPMVYCGLYPIDTAKYNDLREALEKLELNDSSL QYEAETSQALGFGFRCGFLGMLHMEIIQERIEREFNIDLITTAPSVIYDVYMTDGEKV VVDNPSNMPDPQKIERVEEPYVKATMMVPNDYVGAVMELCQGKRGNFIDMQYLDANRV SIIYDMPLAEIVYEFFDQLKSSTKGYASFDYELIGYKPSKLVKMDIMLNGEKIDALSF IVHRDYAYERGKVIVEKLKELIPRQQFEVPVQAAIGQKIVARSTIKAMRKNVLAKCYG GDISRKRKLLEKQKEGKRRMKQVGSVEVPQEAFMAVLKMDDSPKKQ*" /label="lepA CDS" gene complement(2154800..2156638) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /label="lepA gene" downshifts complement(2154822) /Source="Nicolas_upshifts" /id="D1319" /incds=0 /nref=15 /ntot=213 /MaxReadThrough="5.2925" /MaxDrop="3.979" /score="5.45344919" /energy="-14" /TU="U1985" /idTUdmin="U1984" /TUdmin="-1232" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2156673..2156692) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2156690) /Source="Nicolas_upshifts" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2156708..2156712) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2156772..2157110) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390430.1" /db_xref="EnsemblGenomes-Gn:BSU25520" /db_xref="EnsemblGenomes-Tr:CAB14494" /db_xref="InterPro:IPR020534" /db_xref="SubtiList:BG10440" /db_xref="UniProtKB/Swiss-Prot:P38425" /translation="MIAYFGKCLLLVTIMFLGVLFGMQQANHGMLSMKGYHDPSLKGA FTLTDGKDNEKEASILGETVTAKDLVEKQKELEKVETFNMFSKAGKALSDTVTNTAQS MYEWIRDMNQ*" /label="yqxA CDS" gene complement(2156772..2157110) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /label="yqxA gene" downshifts complement(2156778) /Source="Nicolas_upshifts" /id="D1320" /incds=0 /nref=11 /ntot=43 /MaxReadThrough="2.553" /MaxDrop="3.8126" /score="5.45344919" /energy="-14" /TU="NA" /idTUdmin="U1986" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2157127..2158332) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17376078, 23834622" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17376078, 23834622; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore autolysin (stage II sporulation)" /protein_id="NP_390431.1" /db_xref="EnsemblGenomes-Gn:BSU25530" /db_xref="EnsemblGenomes-Tr:CAB14495" /db_xref="GOA:P37968" /db_xref="InterPro:IPR010897" /db_xref="SubtiList:BG10439" /db_xref="UniProtKB/Swiss-Prot:P37968" /translation="MRNKRRNRQIVVAVNGGKAVKAIFLFIVSLIVIFVLSGVLTSLR PELRPSSDSFYGIAEELPGDVFAHLLQMENHYFASDLSQTDSSFHLSRLSLKLATSIN LEDPRSFLGRELPGFAQFDTEILLAGQGTDYTNMPAESPPPSKVMEEEREANLAEIEK QQTQSDNAQKDPPKQTTGDKKVVFIYHTHNTESYLPLLKGETDPDMARHSKANVTLVG DMFGQALESQGIGATVNKTDIQSKLNKKGLNYARSYDESRPVVKDALASNKNLQYIID IHRDSRRKKDTTATIKGKSYARVAFVVGKKSKNFEENYKIASELHKLMEKKYPGLSTG VFSKGSPGDNGVYNQDLTDRALLLEFGGVDNNLEELQRAANAAADVFSEMYWDAEKVN AASGETKKQ*" /label="spoIIP CDS" gene complement(2157127..2158332) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /label="spoIIP gene" promotor_-10 complement(2158352..2158370) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2158364) /Source="Nicolas_upshifts" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2158386..2158391) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2158395..2159501) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /EC_number="3.4.24.78" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10666631, 10986255, 12807468, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666631, 10986255, 12807468, 23927687; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protease" /protein_id="NP_390432.1" /db_xref="EnsemblGenomes-Gn:BSU25540" /db_xref="EnsemblGenomes-Tr:CAB14496" /db_xref="GOA:P22322" /db_xref="InterPro:IPR005080" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10438" /db_xref="UniProtKB/Swiss-Prot:P22322" /translation="MKKSELDVNQYLIRTDLAVETKEAMANQQAVPTKEIKGFIEKER DHGGIKIRTVDVTKEGAELSGKKEGRYLTLEAQGIRENDSEMQEKVSAVFAEEFSAFL ENLNISKDASCLIVGLGNWNVTPDALGPMAVENLLVTRHLFKLQPENVQEGYRPVSAF APGVMGITGIETSDIIKGVIEQSKPDFVIAIDALAARAVERVNTTIQISDTGIHPGSG VGNKRKDLSKDTLGVPVIAIGVPTVVDAVTIASDTVDYILKHFGREMKDNRPSRSLVP AGMTFGKKKVLTEDDLPDQKQRQSFLGIVGTLQEDEKRQLIHEVLSPLGHNLMVTPKE VDSFIDDMANVLANGLNTALHEKVSQENKGSYNH*" /label="gpr CDS" gene complement(2158395..2159501) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /label="gpr gene" promotor_-10 complement(2159529..2159540) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2159536) /Source="Nicolas_upshifts" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2159555..2159561) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2159600..2159603 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2159616 /Source="Nicolas_upshifts" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2159619..2159638 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2159630..2159704 /Source="Nicolas_S_feature" /locus_tag="new_2635740_2635814" /HighExp="HiTm, LPhT, UNK1, HiOs, dia5, aero, MG 15, SMM, Lbtran, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S961" CDS 2159705..2159971 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16629673, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16629673, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S20 (BS20)" /protein_id="NP_390433.2" /db_xref="EnsemblGenomes-Gn:BSU25550" /db_xref="EnsemblGenomes-Tr:CAB14497" /db_xref="GOA:P21477" /db_xref="InterPro:IPR002583" /db_xref="InterPro:IPR036510" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11643" /db_xref="UniProtKB/Swiss-Prot:P21477" /translation="MPNIKSAIKRTKTNNERRVHNATIKSAMRTAIKQVEASVANNEA DKAKTALTEAAKRIDKAVKTGLVHKNTAARYKSRLAKKVNGLSA*" /label="rpsT CDS" gene 2159705..2159971 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /label="rpsT gene" downshifts 2159960 /Source="Nicolas_upshifts" /id="D1321" /incds=0 /nref=244 /ntot=274 /MaxReadThrough="2.22204" /MaxDrop="8.54705" /score="33.3621187" /energy="-12.3" /TU="NA" /idTUdmin="U1988" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2159986..2161029) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9434186, 11432857, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9434186, 11432857, 12060778, 12682299, 22333191, 23525462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase clamp loader delta subunit" /protein_id="NP_390434.1" /db_xref="EnsemblGenomes-Gn:BSU25560" /db_xref="EnsemblGenomes-Tr:CAB14498" /db_xref="GOA:P54459" /db_xref="InterPro:IPR005790" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR010372" /db_xref="InterPro:IPR027417" /db_xref="PDB:3ZH9" /db_xref="SubtiList:BG11642" /db_xref="UniProtKB/Swiss-Prot:P54459" /translation="MVFDVWKSLKKGEVHPVYCLYGKETYLLQETVSRIRQTVVDQET KDFNLSVFDLEEDPLDQAIADAETFPFMGERRLVIVKNPYFLTGEKKKEKIEHNVSAL ESYIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFMMEAKELNAKETTDFTVNLAK TEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDREEITLDDVKMLVARSLEQN IFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAEQGYGQK QIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLL QLLKRNEKNDPHY*" /label="holA CDS" gene complement(2159986..2161029) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /label="holA gene" downshifts complement(2160031) /Source="Nicolas_upshifts" /id="D1322" /incds=0 /nref=14 /ntot=198 /MaxReadThrough="1.76478" /MaxDrop="4.34213" /score="-1.12561483" /energy="-8.1" /TU="NA" /idTUdmin="U1989" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2161058..2161077) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2161069..2161218) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513978.1" /translation="MKNLEAKVTFSVLVIIAFLQAVPGACEQAFNINGEAAVRLPLYY FANSI*" /label="hypothetical protein CDS" gene complement(2161069..2161218) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /label="gene" upshifts complement(2161070) /Source="Nicolas_upshifts" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2161091..2161095) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2161093..2161432) /Source="Nicolas_S_feature" /locus_tag="new_2637203_2637542_c" /HighExp="S8, S6, S7, BT, S5, C30, Pyr, G/S, B36, GM 150" /AntisenseName="yqzM" /AntisenseCor="-2.0369593011890001E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S962" downshifts complement(2161136) /Source="Nicolas_upshifts" /id="D1323" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="5.04584" /MaxDrop="3.298" /score="-1.12561483" /energy="-8.1" /TU="U1991,U1995" /idTUdmin="U1992" /TUdmin=748 /isTUend="FALSE" /label="downshifts" promotor_-35 2161205..2161211 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2161225..2161244 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2161226 /Source="Nicolas_upshifts" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="upshifts" CDS 2161259..2161393 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097762.1" /db_xref="EnsemblGenomes-Gn:BSU25569" /db_xref="EnsemblGenomes-Tr:CAX52662" /db_xref="GOA:C0H453" /db_xref="InterPro:IPR025416" /db_xref="UniProtKB/Swiss-Prot:C0H453" /translation="MNDFEKNVQSKRNDAVDSAVGFVVSFGFFAFLFVMATVIHLVGS *" /label="yqzM CDS" gene 2161259..2161393 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /label="yqzM gene" downshifts 2161387 /Source="Nicolas_upshifts" /id="D1324" /incds=0 /nref=156 /ntot=250 /MaxReadThrough="3.51266" /MaxDrop="6.2258" /score="20.1810918" /energy="-12.1" /TU="U1990" /idTUdmin="U1990" /TUdmin="-465" /isTUend="FALSE" /label="downshifts" CDS complement(2161433..2163763) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12123453, 15661011, 16751195, 17630974, 21397556, 27318187" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123453, 15661011, 16751195, 17630974, 21397556, 27318187; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="DNA channel for uptake in competent cells" /protein_id="NP_390435.1" /db_xref="EnsemblGenomes-Gn:BSU25570" /db_xref="EnsemblGenomes-Tr:CAB14499" /db_xref="GOA:P39695" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004477" /db_xref="InterPro:IPR004797" /db_xref="InterPro:IPR025405" /db_xref="InterPro:IPR035681" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10482" /db_xref="UniProtKB/Swiss-Prot:P39695" /translation="MRNSRLLLPMAAASATAGITAAAYFPAIFLFILFLLIILIKTRH AFLIIVCFFSFILFFVLYAVTDSQNVSSYRQGTYQFKAVIDTIPKIDGDRMSMMVETP DKEKWAAAYRIQSAGEKEQLLYIEPGMSCELTGTLEEPNHATVPGAFDYNEYLYRQHI HWNYSVTSIQNCSEPENFKYKVLSLRKHIISFTNSLLPPDSTGIVQALTVGDRFYVED EVLTAYQKLGVVHLLAISGLHVGILTAGLFYIMIRLGITREKASILLLLFLPLYVMLT GAAPSVLRAALMSGVYLAGSLVKWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAV SFSLILSSSIFQQVKTSLGQLTIVSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFY TFCILPGAVAGVLLLSLSASFGRLFFSWFDLLISWINRLITNIADVDVFTIMIAHPAP VLLFLFTVTIILLLMAIEKRSLSQLMVTGGICCTVMFLLFIYPCLSSEGEVDMIDIGQ GDSMFVGAPHQRGRVLIDTGGTLSYSSEPWREKQHPFSLGEKVLIPFLTAKGIKQLDA LILTHADQDHIGEAEILLKHHKVKRLVIPKGFVSEPKDEKVLQAAREEGVAIEEVKRG DVLQIKDLQFHVLSPEAPDPASKNNSSLVLWMETGGMSWILTGDLEKEGEQEVMNVFP NIKADVLKVGHHGSKGSTGEEFIQQLQPKTAIISAGKNNRYHHPHQKVLQLLQRHSIR VLRTDQNGTIQYRYKNRVGTFSVYPPYDTSDITETN*" /label="comEC CDS" gene complement(2161433..2163763) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /label="comEC gene" promotor_-10 complement(2161450..2161469) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2161466) /Source="Nicolas_upshifts" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2161483..2161492) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2163767..2164336) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /EC_number="3.5.4.12" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7768800, 26416910; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="dCMP deaminase associated to DNA transport (competence)" /protein_id="NP_390436.1" /db_xref="EnsemblGenomes-Gn:BSU25580" /db_xref="EnsemblGenomes-Tr:CAB14500" /db_xref="GOA:P32393" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR013404" /db_xref="InterPro:IPR015517" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR016473" /db_xref="InterPro:IPR035105" /db_xref="SubtiList:BG10481" /db_xref="UniProtKB/Swiss-Prot:P32393" /translation="MERISWNQYFMAQSHLLALRSTCPRLSVGATIVRDKRMIAGGYN GSIAGGVHCADEGCLMIDDHCARTIHAEMNAILQCSKFGVPTDGAEIYVTHYPCIQCC KSIIQAGIKTVYYAEDYKTHPYAQELFEQAGVTVEQVELDEMIVDLKNREKLSFVAGL IGKLADAGLAEEELKKIHEQANTLFTSYV*" /label="comEB CDS" gene complement(2163767..2164336) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /label="comEB gene" promotor_-10 complement(2164363..2164382) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2164373) /Source="Nicolas_upshifts" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2164397..2164404) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2164403..2165020) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16751195, 21278288, 22398145, 25727469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751195, 21278288, 22398145, 25727469; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane bound high-affinity DNA-binding receptor" /protein_id="NP_390437.1" /db_xref="EnsemblGenomes-Gn:BSU25590" /db_xref="EnsemblGenomes-Tr:CAB14501" /db_xref="GOA:P39694" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004509" /db_xref="InterPro:IPR004787" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR019554" /db_xref="SubtiList:BG10480" /db_xref="UniProtKB/Swiss-Prot:P39694" /translation="MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTET ENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRTGDRVSQAIEKAGGTSEQADEAQ VNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGV GPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK*" /label="comEA CDS" gene complement(2164403..2165020) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /label="comEA gene" promotor_-35 2165041..2165046 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2165058 /Source="Nicolas_upshifts" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2165062..2165080 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2165081..2165095) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2165083) /Source="Nicolas_upshifts" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2165085..2165932) /Source="Nicolas_S_feature" /locus_tag="new_2641195_2642042_c" /HighExp="C30, T0.30H, T-2.40H, GM 150, T1.30H, T-0.40H, T-1.10H, T-1.40H, T1.0H, T0.0H" /AntisenseName="comER" /AntisenseCor="-8.2389039371154299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S963" promotor_-35 complement(2165104..2165108) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2165104..2165925 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /EC_number="1.5.1.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7968523, 11418582, 27446060, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrroline-5'-carboxylate reductase" /protein_id="NP_390438.1" /db_xref="EnsemblGenomes-Gn:BSU25600" /db_xref="EnsemblGenomes-Tr:CAB14502" /db_xref="GOA:P39696" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10479" /db_xref="UniProtKB/Swiss-Prot:P39696" /translation="MKIGFIGTGNMGTILIESFIESKAADPSNMTITNRTIEKALHIK NRYNSINVTESLEKLVSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTE QLEQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISHPLQIESD ITRVASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELY TLPALQEKVCVKGGVTGEGIKALESGVQDMFHRVFQNTHMKYEEDISAVKKQFHV*" /label="comER CDS" gene 2165104..2165925 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /label="comER gene" promotor_-10 complement(2165920..2165939) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2165926..2166006 /Source="Nicolas_S_feature" /locus_tag="new_2642036_2642116" /HighExp="S4, S5, S3, S6, S7, B36, Pyr, G/S, S8, BT" /AntisenseName="yqeM" /AntisenseCor="-0.52267300854840604" /AntisenseRegPval="-19.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S964" upshifts complement(2165933) /Source="Nicolas_upshifts" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2165953..2165960) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2165966 /Source="Nicolas_upshifts" /id="D1325" /incds=0 /nref=45 /ntot=64 /MaxReadThrough="2.4803" /MaxDrop="5.1403" /score="7.09525061" /energy="-10.5" /TU="NA" /idTUdmin="U1993" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2165991..2166734) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390439.1" /db_xref="EnsemblGenomes-Gn:BSU25610" /db_xref="EnsemblGenomes-Tr:CAB14503" /db_xref="GOA:P54458" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11641" /db_xref="UniProtKB/Swiss-Prot:P54458" /translation="MIYQGFASVYDELMSHAPYDQWTKWIEASLPEKGRILDLACGTG EISIRLAEKGFEVTGIDLSEEMLSFAQQKVSSSQPILFLQQDMREITGFDGQFDAVVI CCDSLNYLKTKNDVIETFKSVFRVLKPEGILLFDVHSSFKIAEVFPDSTFADQDEDIS YIWQSFAGSDELSVIHDMSFFVWNGEAYDRFDETHEQRTFPVEEYEEMLKNCGFQLHR VTADFTDTEPSAQSERLFFKAQKSKTIVS*" /label="yqeM CDS" gene complement(2165991..2166734) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /label="yqeM gene" downshifts complement(2166021) /Source="Nicolas_upshifts" /id="D1326" /incds=0 /nref=144 /ntot=230 /MaxReadThrough="1.41467" /MaxDrop="5.51802" /score="7.9251293" /energy="-10.5" /TU="NA" /idTUdmin="U1996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2166731..2167087) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 16980477, 22238375, 22238376, 22829778, 26299947; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal silencing factor" /protein_id="NP_390440.1" /db_xref="EnsemblGenomes-Gn:BSU25620" /db_xref="EnsemblGenomes-Tr:CAB14504" /db_xref="GOA:P54457" /db_xref="InterPro:IPR004394" /db_xref="SubtiList:BG11640" /db_xref="UniProtKB/Swiss-Prot:P54457" /translation="MNQKSILKIAAAACDDKRAEDILALDMEGISLVADYFLICHGNS DKQVQAIAREIKDQADENGIQVKKMEGFDEARWVLVDLGDVVVHVFHKDERSYYNLEK LWGDAPLADLDFGMNQ*" /label="rsfS CDS" gene complement(2166731..2167087) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /label="rsfS gene" CDS complement(2167105..2167665) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390441.1" /db_xref="EnsemblGenomes-Gn:BSU25630" /db_xref="EnsemblGenomes-Tr:CAB14505" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR005249" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11639" /db_xref="UniProtKB/Swiss-Prot:P54456" /translation="MNREEALACVKQQLTEHRYIHTVGVMNTAIELAERFGADSKKAE IAAIFHDYAKFRPKEEMKQIIAREKMPAHLLDHNPELWHAPVGAYLVQREAGVQDEDI LDAIRYHTSGRPGMTLLEKVIYVADYIEPNRAFPGVDEVRKLAETDLNQALIQSIKNT MVFLMKKNQPVFPDTFLTYNWLVSGS*" /label="yqeK CDS" gene complement(2167105..2167665) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /label="yqeK gene" CDS complement(2167655..2168224) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /EC_number="2.7.7.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11704676, 12682299, 19716475, 23204464, 25631047; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide adenylyltransferase" /protein_id="NP_390442.1" /db_xref="EnsemblGenomes-Gn:BSU25640" /db_xref="EnsemblGenomes-Tr:CAB14506" /db_xref="GOA:P54455" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR005248" /db_xref="InterPro:IPR014729" /db_xref="PDB:1KAM" /db_xref="PDB:1KAQ" /db_xref="SubtiList:BG11638" /db_xref="UniProtKB/Swiss-Prot:P54455" /translation="MKKIGIFGGTFDPPHNGHLLMANEVLYQAGLDEIWFMPNQIPPH KQNEDYTDSFHRVEMLKLAIQSNPSFKLELVEMEREGPSYTFDTVSLLKQRYPNDQLF FIIGADMIEYLPKWYKLDELLNLIQFIGVKRPGFHVETPYPLLFADVPEFEVSSTMIR ERFKSKKPTDYLIPDKVKKYVEENGLYES*" /label="nadD CDS" gene complement(2167655..2168224) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /label="nadD gene" CDS complement(2168236..2168526) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 17005971, 17105995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 17005971, 17105995; Product type f: factor" /codon_start=1 /transl_table=11 /product="50S RNA-binding protein" /protein_id="NP_390443.1" /db_xref="EnsemblGenomes-Gn:BSU25650" /db_xref="EnsemblGenomes-Tr:CAB14507" /db_xref="GOA:P54454" /db_xref="InterPro:IPR001890" /db_xref="InterPro:IPR017924" /db_xref="InterPro:IPR035920" /db_xref="SubtiList:BG11637" /db_xref="UniProtKB/Swiss-Prot:P54454" /translation="MLTGKQKRFLRSKAHHLTPIFQVGKGGVNDNMIKQIAEALEARE LIKVSVLQNCEEDKNDVAEALVKGSRSQLVQTIGNTIVLYKESKENKQIELP*" /label="yqeI CDS" gene complement(2168236..2168526) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /label="yqeI gene" CDS complement(2168520..2169362) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /EC_number="1.1.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2104604, 12906820, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate 5-dehydrogenase" /protein_id="NP_390444.2" /db_xref="EnsemblGenomes-Gn:BSU25660" /db_xref="EnsemblGenomes-Tr:CAB14508" /db_xref="GOA:P54374" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR011342" /db_xref="InterPro:IPR013708" /db_xref="InterPro:IPR022893" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11522" /db_xref="UniProtKB/Swiss-Prot:P54374" /translation="MKKLYGVIGNPIGHSMSPDIHNASLKDLGLDGHYHAFKVEENDL EDAVKGIRALGVQGINVTVPHKVSIMDYLDHIDESAKVLGAVNTVRREGDKLVGYNTD GEGFVKSLMKVLDKPISELSFLMIGAGGAARAIFTTIVRNTPKKFDICNRTLEKAKRL TEATPSFHNKEVLSIKEAEERLEQYDVIIHTTSVGMYPNVDDVPLSLQRAASSAVVCD IVYNPIQTALLKEASQKGLKTLDGVGMFVEQAALSFQLWTGQEPNIEKMRSIVIGKLG GTEC*" /label="aroE CDS" gene complement(2168520..2169362) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /label="aroE gene" downshifts 2169354 /Source="Nicolas_upshifts" /id="D1327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="0.240279999999999" /MaxDrop="3.04009" /score="0.0642154872" /energy="-17" /TU="NA" /idTUdmin="U1993" /TUdmin=3388 /isTUend="FALSE" /label="downshifts" CDS complement(2169380..2170480) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent GTPase involved in ribosome 30S assembly" /protein_id="NP_390445.1" /db_xref="EnsemblGenomes-Gn:BSU25670" /db_xref="EnsemblGenomes-Tr:CAB14509" /db_xref="GOA:P54453" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019988" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="SubtiList:BG11636" /db_xref="UniProtKB/Swiss-Prot:P54453" /translation="MEKVVCIGCGVTIQTEDKTGLGYAPPASLTKENVICQRCFRLKN YNEIQDVSLTDDDFLNILHGIGETDSLVVKIVDIFDFNGSWINGLQRLVGGNPILLVG NKADILPKSLKRERLIQWMKREAKELGLKPVDVFLVSAGRGQGIREVIDAIEHYRNGK DVYVVGCTNVGKSTFINRIIKEVSGEEDIITTSQFPGTTLDAIEIPLDDGSSLYDTPG IINNHQMAHYVNKKDLKILSPKKELKPRTFQLNDQQTLYFGGLARFDYVSGERSPFIC YMPNELMIHRTKLENADALYEKHAGELLTPPGKDEMDEFPELVAHTFTIKDKKTDIVF SGLGWVTVHDADKKVTAYAPKGVHVFVRRSLI*" /label="rgpH CDS" gene complement(2169380..2170480) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /label="rgpH gene" CDS complement(2170484..2171002) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase (active on GMP and Glc-6-P)" /protein_id="NP_390446.1" /db_xref="EnsemblGenomes-Gn:BSU25680" /db_xref="EnsemblGenomes-Tr:CAB14510" /db_xref="GOA:P54452" /db_xref="InterPro:IPR006356" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR006549" /db_xref="InterPro:IPR010021" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11635" /db_xref="UniProtKB/Swiss-Prot:P54452" /translation="MLKKFFLPDEFVKNIFHITPEKLKERNVKGIITDLDNTLVEWDR PNATPRLIEWFEEMKEHGIKVTIVSNNNERRVKLFSEPLGIPFIYKARKPMGKAFNRA VRNMELKKEDCVVIGDQLLTDVLGGNRNGYHTILVVPVASSDGFITRFNRQVERRILS ALKRKGHIQWEE*" /label="yqeG CDS" gene complement(2170484..2171002) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /label="yqeG gene" promotor_-10 complement(2170912..2170929) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2170926) /Source="Nicolas_upshifts" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2170945..2170948) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2171003..2171564) /Source="Nicolas_S_feature" /locus_tag="new_2647113_2647674_c" /HighExp="G135, G180, G150, Paraq, Oxctl, C30, Heat, HPh, BMM, LPh" /AntisenseName="sda" /AntisenseCor="-8.6107693225382295E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S965" downshifts complement(2171036) /Source="Nicolas_upshifts" /id="D1328" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="6.83118" /MaxDrop="5.26138" /score="9.20556883" /energy="-8.6" /TU="U1998" /idTUdmin="U1999" /TUdmin=616 /isTUend="FALSE" /label="downshifts" promotor_-35 2171227..2171234 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2171245..2171345 /Source="Nicolas_S_feature" /locus_tag="new_2647355_2647455" /HighExp="T3.0H, T-0.40H, MG 150, T5.0H, T-1.40H, T4.0H, T2.30H, T0.0H, T3.30H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S966" promotor_-10 2171245..2171264 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2171245 /Source="Nicolas_upshifts" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(2171295..2171553) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /product="antisense RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sdaM RNA" gene complement(2171295..2171553) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /label="sdaM gene" CDS 2171346..2171504 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15023339, 16796683, 19040634, 22720735, 28752667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023339, 16796683, 19040634, 22720735, 28752667; Product type f: factor" /codon_start=1 /transl_table=11 /product="check point factor coupling initiation of sporulation and replication initiation" /protein_id="YP_054588.1" /db_xref="EnsemblGenomes-Gn:BSU25690" /db_xref="EnsemblGenomes-Tr:CAE01463" /db_xref="GOA:Q7WY62" /db_xref="InterPro:IPR015064" /db_xref="InterPro:IPR036916" /db_xref="PDB:1PV0" /db_xref="PDB:3FYR" /db_xref="SubtiList:BG14183" /db_xref="UniProtKB/Swiss-Prot:Q7WY62" /translation="MNWVPSMRKLSDELLIESYFKATEMNLNRDFIELIENEIKRRSL GHIISVSS*" /label="sda CDS" gene 2171346..2171504 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /label="sda gene" S_feature 2171505..2171751 /Source="Nicolas_S_feature" /locus_tag="new_2647615_2647861" /HighExp="Cold, T-0.40H, MG 150, T5.0H, T4.0H, C30, T2.30H, M9-tran, S2, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S967" promotor_-10 complement(2171552..2171571) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2171563) /Source="Nicolas_upshifts" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2171587..2171591) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2171615..2171762) /Source="Nicolas_S_feature" /locus_tag="new_2647725_2647872_c" /HighExp="S8, S7, S6, Etha, LBGstat, T0.30H, Salt, BT, LPhT, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99948400000000004" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S968" downshifts complement(2171652) /Source="Nicolas_upshifts" /id="D1329" /incds=0 /nref=12 /ntot=92 /MaxReadThrough="2.70676" /MaxDrop="4.386" /score="9.20556883" /energy="-8.6" /TU="NA" /idTUdmin="U1999" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2171708 /Source="Nicolas_upshifts" /id="D1330" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="5.36291" /MaxDrop="2.1106" /score="10.3636587" /energy="-6.2" /TU="U1997" /idTUdmin="U1997" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 2171753..>2171830 /Source="Nicolas_S_feature" /locus_tag="new_2647863_2648916" /HighExp="T-0.40H, Cold, M40t90, T0.0H, C30, Glucon, S2, T1.30H, T2.30H, T2.0H" /AntisenseName="yqeF" /AntisenseCor="-0.39616310996746001" /AntisenseRegPval="-10.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S969" promotor_-10 complement(2171757..2171776) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2171762) /Source="Nicolas_upshifts" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2171789..2171798) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(2171830,2171832) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_003" N_region 2171831 /note="inserted C residue" /created_by="User" /modified_by="User" /label="IIG_Bs27_003" S_feature <2171832..2172274 /Source="Nicolas_S_feature" /locus_tag="new_2701783_2703117" /HighExp="S8, S6, S7, S5, S4, BT, B36, dia15, C30, H2O2" /AntisenseName="psiE" /AntisenseCor="0.376363934894826" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="0.117191" /TUshortSig="Sig-" /TUshortPSig="0.218" /TUlongSig="NA" /TUlongPSig="NA" /label="S984" CDS complement(2171845..2172261) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12897016, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="phosphate starvation inducible protein" /protein_id="NP_390518.2" /db_xref="EnsemblGenomes-Gn:BSU26410" /db_xref="EnsemblGenomes-Tr:CAB14582" /db_xref="GOA:P54445" /db_xref="InterPro:IPR009315" /db_xref="InterPro:IPR020948" /db_xref="SubtiList:BG11784" /db_xref="UniProtKB/Swiss-Prot:P54445" /translation="MRFSNKFKKVPYLLQALLNVCLFFLALALSALLISETWYIVLFV YKSLFNKVDSYYEMLGELLIFFMYFEFIALIIKYFKSDFHFPLRYFIYIGITAVIRLI IIDHDQAISTFWWAMAILAMICGFFIANRRNSVVEH*" /label="psiE CDS" gene complement(2171845..2172261) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /label="psiE gene" CDS complement(2172307..2173605) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YrkP]" /protein_id="NP_390519.1" /db_xref="EnsemblGenomes-Gn:BSU26420" /db_xref="EnsemblGenomes-Tr:CAB14583" /db_xref="GOA:P54444" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11783" /db_xref="UniProtKB/Swiss-Prot:P54444" /translation="MAHLKFTLTKKLALLIMVAAIVSGVIFLTLQKITDDLIEGYLSS EEYYHEESARYIQKFSKYVSENELSTSDRKAFGEWVKKENYINLTIFKDQELQYDSIY SESDYGKEKLTQYAQNHSHPVKFSDGEGRVIIDGFYSSRYYDLAFALDLLGATLIFLI IVLFGIRQSLRYLKTIHQEIHILEGGELDYEMTIKGHDELAMIAKSIEDLRKAFLDKL KAIEELQAESRSLVTEMSHDMRTPLTSLIMNLEFAKKEGGEAGASKDRYVANAYGKAL QLKSLSDNLFAYFLLNKEYEADLETVAVKEVIYDLISDQIAILHQEHFRVHISGELPE TYINVNLEELGRVFDNVMSNLLKYADPEEKISITFVSDQEIFEIHVSNTIKLADITPE SNGLGERSIARMMSRMQGQFHSIQKNSKYYIVLRFWNTKM*" /label="yrkQ CDS" gene complement(2172307..2173605) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /label="yrkQ gene" CDS complement(2173592..2174287) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18175906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18175906; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YrkQ]" /protein_id="NP_390520.1" /db_xref="EnsemblGenomes-Gn:BSU26430" /db_xref="EnsemblGenomes-Tr:CAB14584" /db_xref="GOA:P54443" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11782" /db_xref="UniProtKB/Swiss-Prot:P54443" /translation="MAYRILVVEDDEDIGDLLEESLTRAGYEVLRAKDGKRALQLVND SLDLVILDIMMPGISGIETCQHIRKSSNVPILFLTARSSTLDKTEGLLAGGDDYMTKP FSEEELHARVIAQLRRYTIYQEKKEQEETFLIGGKLRVSEEFNEVWKEEKQIKLSDLE YRILKLLMNKRNKIFSAQNIYESVWGQPYFYCSNNTVMVHIRKLRSKIEDDPARPVYI KTEWGRGYRFGAS*" /label="yrkP CDS" gene complement(2173592..2174287) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /label="yrkP gene" misc_feature complement(2174353..2174370) /Source="Nicolas_upshift_promotors" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2174362) /Source="Nicolas_upshifts" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2174448..2174454 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2174461..2174479 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2174476 /Source="Nicolas_upshifts" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2174555..2175772 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390521.1" /db_xref="EnsemblGenomes-Gn:BSU26440" /db_xref="EnsemblGenomes-Tr:CAB14585" /db_xref="GOA:P54442" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11781" /db_xref="UniProtKB/Swiss-Prot:P54442" /translation="MIVQKEGRGQPVSLRERVHFLDIVRGFALLGIIIVNYFLIVDSV KGFEMASDDVLHKLVSWFAEGKFVTLFSFLFGVGFMIFMDRAAQKVESPNKLFARRLS ILLGFGILHITFVWVGDILAFYAVSGFLLLAFYKRTAKTVLRWIIALIVFQFLTPVFT MLYNVINTAGSKNPNFSEFTLFSHSSLTYMESISTRWTDMVTMAAGSFSMIYSMFLMF LLGVYFVKMEFFKDMEAKKPIWKRIWIISTIAFLITQSSILLDMFNLSENMLWKDISS VLGQNGGLTGSMFYMSTFAMLFLYLPQLRGPMMIFTKVGRMSLTCYLLHSIIGTVLFL RYGFGLADHIQSAGTFMFSLAVYFVLMSFSTLWLKRFRYGPMELVWRKLTYGKVNGSP KATPLHSEKSIQK*" /label="yrkO CDS" gene 2174555..2175772 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /label="yrkO gene" promotor_-35 2175014..2175021 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2175036..2175055 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2175052 /Source="Nicolas_upshifts" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2175691..2175939 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513983.1" /translation="MAQADVRQSKRESQSNSAAFGKIYSEITPLHRLHDFKLVLLNEA GIKRTDLIYGLVIFISFRLLWANKSTRVYSMCIAHDRI*" /label="hypothetical protein CDS" gene 2175691..2175939 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /label="gene" S_feature complement(2175868..2176915) /Source="Nicolas_S_feature" /locus_tag="new_2706711_2707758_c" /HighExp="Diami, C30, dia15, dia5, Lbstat, S8, C90, G180, H2O2, G135" /AntisenseName="yrkN" /AntisenseCor="0.40539464433869998" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S985" CDS 2176284..2176841 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /EC_number="2.3.-.-" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390522.1" /db_xref="EnsemblGenomes-Gn:BSU26450" /db_xref="EnsemblGenomes-Tr:CAB14586" /db_xref="GOA:P54441" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11780" /db_xref="UniProtKB/Swiss-Prot:P54441" /translation="MKTKNEPKVILELAKESDLPEFQKKLQEAFAIAVIETFGDCEDG PIPSDNDVQESFNAPGAVVYHILQDGKNVGGAVVRINSQTNHNSLDLFYVSPEYHSQG IGLSAWKAIEAQYPDTVLWETVTPYFEKRNINFYVNKCGFHIVEFYNEHHSNPHMHRN GREDDKPLLNDDDFFRFVKIMKKKD*" /label="yrkN CDS" gene 2176284..2176841 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /label="yrkN gene" S_feature 2176842..2176964 /Source="Nicolas_S_feature" /locus_tag="new_2707685_2707807" /HighExp="S8, Sw, C30, S7, BC, C90, Lbstat, Mal, LoTm, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S986" S_feature complement(2176917..2177331) /Source="Nicolas_S_feature" /locus_tag="new_2707760_2708174_c" /HighExp="M0t90, M40t90, Lbstat, dia5, LPhT, dia15, M9-stat, Lbtran, C90, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S987" downshifts complement(2176960) /Source="Nicolas_upshifts" /id="D1360" /incds=0 /nref=81 /ntot=255 /MaxReadThrough="5.45539" /MaxDrop="5.6563" /score="-3.35079978" /energy="-23.7" /TU="U2041,U2042,U2044,U2045" /idTUdmin="U2042" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" CDS complement(2177332..2177856) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /EC_number="1.6.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase" /protein_id="NP_390524.2" /db_xref="EnsemblGenomes-Gn:BSU26470" /db_xref="EnsemblGenomes-Tr:CAB14588" /db_xref="GOA:P54439" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11778" /db_xref="UniProtKB/Swiss-Prot:P54439" /translation="MKTLVIVIHPNLETSVVNKTWMNRLKQEKDITVHDLYGEYPNFI IDVEKEQQLLLDHERIVFQFPMYWYSSPALLKQWEDDVLTHGWAYGTGGTKLHGKELL LAISLGAQESDYQAGGEYNITISELIRPFQVTANYIGMRFLPAFTQYGTLHLSKEDVK NSAERLVDYLKAEH*" /label="yrkL CDS" gene complement(2177332..2177856) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /label="yrkL gene" promotor_-35 2177704..2177711 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2177722..2177741 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2177736 /Source="Nicolas_upshifts" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2177857..2177944) /Source="Nicolas_S_feature" /locus_tag="new_2708700_2708787_c" /HighExp="dia5, Etha, dia15, M9-stat, M0t90, Lbtran, Diami, C90, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S988" promotor_-10 complement(2177939..2177958) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2177944) /Source="Nicolas_upshifts" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2177946..>2178082) /Source="Nicolas_S_feature" /locus_tag="new_2708789_2708942_c" /HighExp="M0t90, M9-stat, Lbstat, M40t90, T1.30H, C90, Lbtran, T0.30H, dia15, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S989" promotor_-35 complement(2177973..2177980) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(2178082,2178089) /created_by="User" /note="deletion occured in betwen marked nucleotides " /modified_by="User" /label="IIG_Bs12" N_region 2178083..2178088 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs12" CDS complement(2178141..2178671) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11700344, 15019740, 17675383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11700344, 15019740, 17675383; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z)" /protein_id="NP_390561.1" /db_xref="EnsemblGenomes-Gn:BSU26840" /db_xref="EnsemblGenomes-Tr:CAB14625" /db_xref="GOA:O05409" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014304" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11976" /db_xref="UniProtKB/Swiss-Prot:O05409" /translation="MNIEDLWDQFHQPLKTYISHRVNDQSIVDDLLQIVFMKIQVHLP NLIDEQKIDSWIYRITRNTIIDFYRTKKTSEILPDVLHFNDSAEEENFTKEATVCIRS TIKRLPEKYREALELTDFQGLSQKELSEKLGISYSGAKSRVQRGRGKLKQLLEGCCHI EADRYGNIVDFRILKE*" /label="sigZ CDS" gene complement(2178141..2178671) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /label="sigZ gene" promotor_-10 complement(2178717..2178736) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2178740) /Source="Nicolas_upshifts" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2178750..2178757) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2178806..2179786 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23990306, 25326299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_390562.2" /db_xref="EnsemblGenomes-Gn:BSU26850" /db_xref="EnsemblGenomes-Tr:CAB14626" /db_xref="GOA:O05408" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG12309" /db_xref="UniProtKB/Swiss-Prot:O05408" /translation="MEYTYLGRTGLRVSRLCLGTMNFGVDTDEKTAFRIMDEALDNGI QFFDTANIYGWGKNAGLTESIIGKWFAQGGQRREKVVLATKVYEPISDPNDGPNDMRG LSLYKIRRHLEGSLKRLQTDHIELYQMHHIDRRTPWDEIWEAFETQVRSGKVDYIGSS NFAGWHLVKAQAEAEKRRFMGLVTEQHKYSLLERTAEMEVLPAARDLGLGVVAWSPLA GGLLGGKALKSNAGTRTAKRADLIEKHRLQLEKFSDLCKELGEKEANVALAWVLANPV LTAPIIGPRTVEQLRDTIKAVEISLDKEILRMLNDIFPGPGGETPEAYAW*" /label="yrpG CDS" gene 2178806..2179786 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /label="yrpG gene" CDS complement(2180060..2181376) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053381, 11566984, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative citrate transporter" /protein_id="NP_390563.1" /db_xref="EnsemblGenomes-Gn:BSU26860" /db_xref="EnsemblGenomes-Tr:CAB14627" /db_xref="GOA:O05407" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG12279" /db_xref="UniProtKB/Swiss-Prot:O05407" /translation="MLTILGFSMVTVFTILIMTKKVSPIVALTITPIVFALIGGFGKG IGDMILEGIQTVASSAALLLFAILFFGILIDAGLFDPLIEKILSIVKGDPVKIAIGSA VLAMLIALDGDGTTTYMITVSAMLPLYKRIGMNPMVMATLAMLSLSIVSGMTPWGGPA TRAISVLGLDPSDFFVPLLPTMLGGIACVIFLAFLMGRKERNRIGIVQLEPRHITKDS SQSYMAATLESEQLKRPRLIYLNLFLVISIMVFIVLGTKHPSVLFLIGFVLALTINYP NVKMQKERIAEHSGNAITVVLLVFSAGVFAGILSGTKMVDAIAGSLISIIPSSMGGFF PVIVALTSIPFTFVLSNDAYYFGMVPIFAEAASAYGIEPVEIARASIMGQPVHLMSPL VASTVLLVSMLKMDLGSFQRFAVKWAVITSLVITLLAIITGAITIL*" /label="yraO CDS" gene complement(2180060..2181376) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /label="yraO gene" S_feature complement(2181377..2181490) /Source="Nicolas_S_feature" /locus_tag="new_2745480_2745593_c" /HighExp="Lbtran, M40t90, Lbstat, HiTm, Mal, Gly, M0t90, S1, T1.0H, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1012" CDS complement(2181491..2182360) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (probes citrate or citrate-related metabolite)" /protein_id="NP_390564.1" /db_xref="EnsemblGenomes-Gn:BSU26870" /db_xref="EnsemblGenomes-Tr:CAB14628" /db_xref="GOA:O07906" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12278" /db_xref="UniProtKB/Swiss-Prot:O07906" /translation="MDEKDWILLKILHEEQSVTKTAERLFTSQPSITYRLKKIEEIFG IELFTKRHKGITFTAEGEHLVAYARRMLQELQDTKDHISNLSKEVQGHLRLGVSSNFA QYKLPKLLREFSTMYPNVQYSVQTGWSTDVMKLLDAGIVQVGILRGSHRWKGVEERLT REKLHIISKKPITIEQLPFLPFIKYKTDASLKTIIEDWMHTNLKQAPIIAMEVDRQET CKEMVKHGLGYSIAPEICLQESDHLYTMELYNAKGKPLMRDTWLMYDQKSLGIKLVKA FIDFLKGEQMVTI*" /label="yraN CDS" gene complement(2181491..2182360) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /label="yraN gene" promotor_-10 complement(2182383..2182402) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2182400) /Source="Nicolas_upshifts" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2182417..2182422) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2182467..2182468) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2182475) /Source="Nicolas_upshifts" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2182505..2182506) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2182505..2183608 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /EC_number="5.3.3.7" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11294638, 12473114, 14702315, 17567742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate isomerase" /protein_id="NP_390565.2" /db_xref="EnsemblGenomes-Gn:BSU26880" /db_xref="EnsemblGenomes-Tr:CAB14629" /db_xref="GOA:O07931" /db_xref="InterPro:IPR007400" /db_xref="SubtiList:BG12277" /db_xref="UniProtKB/Swiss-Prot:O07931" /translation="MVKTNVTIMRGGTSKGVFFHESAMPNNKNEWEPFLLDVMGSPDK RQIDGLGGGNSLTSKVAIIKKAYTSDIDVHYTFGQVSISEEKVDFKGNCGNISAAVGP FAIEEGLVKAKEPMTAVRILNTNTNKMIIAEVEVEDGQVKYDGDVTISGVPGSGSPIY LNFHDAAGSVTGHLLPTGNSSEFLDTSQGQIEVSIIDYANPLVFVEASSIGLDGTELA EEFTDLQLAQFEELRSIAAEKCGFASRFSATKLSPAVPKLAIVAKPEKYKDSTGAWHS SVEMDLHIRMMSMQKPHQALAVTGAICTTRALSVEGAIPARIAKNHSTKVRLAHSSGI IETMVEPTGIKIVRTARRIMDGTVYTHGDYQMM*" /label="prpF CDS" gene 2182505..2183608 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /label="prpF gene" misc_feature 2183498..2183517 /Source="Nicolas_upshift_promotors" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2183504 /Source="Nicolas_upshifts" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2183855) /Source="Nicolas_upshifts" /id="D1374" /incds=0 /nref=123 /ntot=254 /MaxReadThrough="2.33762" /MaxDrop="7.47213" /score="6.31571576" /energy="-8.7" /TU="U2071" /idTUdmin="U2071" /TUdmin="-33" /isTUend="FALSE" /label="downshifts" CDS complement(2183881..2184714) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /EC_number="3.2.1.132" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11065371, 11320136, 1664582, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11065371, 11320136, 1664582, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chitosanase" /protein_id="NP_390566.1" /db_xref="EnsemblGenomes-Gn:BSU26890" /db_xref="EnsemblGenomes-Tr:CAB14630" /db_xref="GOA:O07921" /db_xref="InterPro:IPR000400" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG11923" /db_xref="UniProtKB/Swiss-Prot:O07921" /translation="MKISMQKADFWKKAAISLLVFTMFFTLMMSETVFAAGLNKDQKR RAEQLTSIFENGTTEIQYGYVERLDDGRGYTCGRAGFTTATGDALEVVEVYTKAVPNN KLKKYLPELRRLAKEESDDTSNLKGFASAWKSLANDKEFRAAQDKVNDHLYYQPAMKR SDNAGLKTALARAVMYDTVIQHGDGDDPDSFYALIKRTNKKAGGSPKDGIDEKKWLNK FLDVRYDDLMNPANHDTRDEWRESVARVDVLRSIAKENNYNLNGPIHVRSNEYGNFVI K*" /label="csn CDS" gene complement(2183881..2184714) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /label="csn gene" misc_feature complement(2184744..2184763) /Source="Nicolas_upshift_promotors" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2184753) /Source="Nicolas_upshifts" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2184919..2184923 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2184934..2185156 /Source="Nicolas_S_feature" /locus_tag="new_2749037_2749259" /HighExp="Lbstat, M9-stat, B60, M0t90, M40t90, T1.30H, T2.0H, T3.0H, T2.30H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97565800000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1013" upshifts 2184934 /Source="Nicolas_upshifts" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2184938..2184957 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2185157..2185420 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390567.1" /db_xref="EnsemblGenomes-Gn:BSU26900" /db_xref="EnsemblGenomes-Tr:CAB14631" /db_xref="GOA:O07917" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12276" /db_xref="UniProtKB/Swiss-Prot:O07917" /translation="MAYVKATAILPEKLISEIQKYVQGKTIYIPKPESSHQKWGACSG TRKLIDDRNASIKKAFKNGKTIHQLSDEYHLSIETIKKIVYSK*" /label="yraL CDS" gene 2185157..2185420 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /label="yraL gene" downshifts 2185408 /Source="Nicolas_upshifts" /id="D1375" /incds=0 /nref=71 /ntot=223 /MaxReadThrough="1.7419" /MaxDrop="4.94534" /score="-1.04752822" /energy="-9.9" /TU="NA" /idTUdmin="U2072" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS 2185557..2186372 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390568.2" /db_xref="EnsemblGenomes-Gn:BSU26910" /db_xref="EnsemblGenomes-Tr:CAB14632" /db_xref="GOA:O07937" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12275" /db_xref="UniProtKB/Swiss-Prot:O07937" /translation="MTINNGTLQVPGANIHYQVRGSGPIILLVHGGGGDADKFHHVAN HLANWYTVVTYDRRGHSRSNLANQIEGYRVETHSDDAHRLLAKITNKPAYVFGSSSGA VIGLDLCIRHPEQVHVMIPHEPILLQLLHGNELKQAEQFMEDLKKNHRSEVIKLMSRL ETDEQSKAVLTKRLLGNSTYFTEYEIQGILSYTLDFEALKTVFTSSPMKILPAGGSAS RELFPYRCANALAEQLETEWVEFPGNHTGYTMYHKEFSERLHDMLEKEKKHTC*" /label="yraK CDS" gene 2185557..2186372 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /label="yraK gene" S_feature complement(2186707..2186779) /Source="Nicolas_S_feature" /locus_tag="new_2750810_2750882_c" /HighExp="BC, Lbstat, Sw, M40t90, M0t90, S2, BI, BT, S3, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1014" downshifts complement(2186750) /Source="Nicolas_upshifts" /id="D1376" /incds=0 /nref=44 /ntot=205 /MaxReadThrough="1.43644" /MaxDrop="4.78753" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2073" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2186780..2187136) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390569.2" /db_xref="EnsemblGenomes-Gn:BSU26920" /db_xref="EnsemblGenomes-Tr:CAB14633" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12274" /db_xref="UniProtKB/Swiss-Prot:O07934" /translation="MTKLKMLSMLTVMIASLFIFSSQALAVQYFTVSTSSGAPVNMRS GPGTNYPIMLSIPSGSRVPYYCYAYGTTVTGKYGTSNIWDQIQWKDSRGVVNIGYVSD TYVYTGSDGPVGYKCN*" /label="yraJ CDS" gene complement(2186780..2187136) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /label="yraJ gene" CDS complement(2187189..2187548) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390570.2" /db_xref="EnsemblGenomes-Gn:BSU26930" /db_xref="EnsemblGenomes-Tr:CAB14634" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12273" /db_xref="UniProtKB/Swiss-Prot:O07909" /translation="MNKLKRLSMLTVMIASVFIFSSHALAAQYYTVSTSSGAPVNMRS GPGTSWGIVTTIPSGTRIPIYCYKTGTTVTGKYGTSNIWNYTERTLASGEIVPGFVSD TYMYTGSDGPVVPKCSW*" /label="yraI CDS" gene complement(2187189..2187548) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /label="yraI gene" misc_feature complement(2187641..2187660) /Source="Nicolas_upshift_promotors" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2187651) /Source="Nicolas_upshifts" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2187820..2187921) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513987.1" /translation="MIGEKGGVSMNREEAWIQGSSTLIELIGGNEAA*" /label="hypothetical protein CDS" gene complement(2187820..2187921) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /label="gene" S_feature complement(2187961..2188063) /Source="Nicolas_S_feature" /locus_tag="new_2752064_2752166_c" /HighExp="M40t90, LBGstat, M40t45, M0t90, Lbstat, Lbtran, LBGtran, LPhT, ferm, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.575" /TUlongSig="NA" /TUlongPSig="NA" /label="S1015" downshifts complement(2188003) /Source="Nicolas_upshifts" /id="D1377" /incds=0 /nref=19 /ntot=188 /MaxReadThrough="2.12056" /MaxDrop="4.09264" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2074" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2188064..2188450) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390571.1" /db_xref="EnsemblGenomes-Gn:BSU26940" /db_xref="EnsemblGenomes-Tr:CAB14635" /db_xref="GOA:O07918" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12272" /db_xref="UniProtKB/Swiss-Prot:O07918" /translation="MKLLQIRLLVNDFKKSVEFYKDSLGLPISWLENEMEYALFDNGE TKIELLSRETMAEIVGEEKKSLEGEAQSKFLLQFKVEDVDKTYDDLHEKGVKCENKPH DRKEWSARVAHFRDPDHNLIEIYKML*" /label="yraH CDS" gene complement(2188064..2188450) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /label="yraH gene" misc_feature complement(2188492..2188508) /Source="Nicolas_upshift_promotors" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2188508) /Source="Nicolas_upshifts" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2188641..2188647 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2188662..2188673 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2188662 /Source="Nicolas_upshifts" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="upshifts" CDS 2188699..2188944 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390572.1" /db_xref="EnsemblGenomes-Gn:BSU26950" /db_xref="EnsemblGenomes-Tr:CAB14636" /db_xref="GOA:O07919" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG12271" /db_xref="UniProtKB/Swiss-Prot:O07919" /translation="MDHQTLAAHEAVDLHEIVNFKTLCIAKSKLMQGLVFDQELKDLM EKDVQQSIQDLTELQAVYERASFQAPVPQSRPTPIIN*" /label="yraG CDS" gene 2188699..2188944 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /label="yraG gene" CDS 2188962..2189330 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390573.1" /db_xref="EnsemblGenomes-Gn:BSU26960" /db_xref="EnsemblGenomes-Tr:CAB14637" /db_xref="GOA:O07949" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG12270" /db_xref="UniProtKB/Swiss-Prot:O07949" /translation="MNNDHLDPINSLNVPELADTTFAMDFLIRAKEGVRNTAVALTET ASPDVRALLRKQLMQGIAMHQEITELMISKKWFHPYELSEQYKLDQLSAKNTIMVGNM NLFPDETNRKGMFDRTPDEH*" /label="yraF CDS" gene 2188962..2189330 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /label="yraF gene" CDS 2189349..2190485 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7926692, 17586670; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (involving bacillithiol)" /protein_id="NP_390574.2" /db_xref="EnsemblGenomes-Gn:BSU26970" /db_xref="EnsemblGenomes-Tr:CAB14638" /db_xref="GOA:O06012" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR027399" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11902" /db_xref="UniProtKB/Swiss-Prot:O06012" /translation="MKAVTYQGIKNVVVKDVPDPKIEKSDDMIIKVTSTAICGSDLHL IHGFIPNMQEDYVIGHEPMGIVEEVGSGVTKLKKGDRVIIPFNIACGECFFCKNQLES QCDQSNDNGEMGAYFGYSGQTGGYPGGQAEYLRVPFANFTHFKIPESCEEPDEKLSVI ADAMTTGFWSVDNAGVKKGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVNYRLQH AKRTNKVEIVNFEDHENTGNYLKEITKGGADVVIDAVGMDGKMSDLEFLASGLKLHGG TMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIRSGQAPVIHYMPYMF ELVSTGKIDPGDVVSHVLPLSEAKHGYDIFDSKMDDCIKVVLKP*" /label="adhB CDS" gene 2189349..2190485 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /label="adhB gene" CDS 2190504..2190701 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390575.1" /db_xref="EnsemblGenomes-Gn:BSU26980" /db_xref="EnsemblGenomes-Tr:CAB14639" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13780" /db_xref="UniProtKB/Swiss-Prot:O06011" /translation="MEYALHEVLEVQEMTAFKTLCLTKSKTMKALVSDPKLKEIMQQD VDITTRQLQEFASILSNAKQE*" /label="yraE CDS" gene 2190504..2190701 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /label="yraE gene" CDS 2190717..2191016 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390576.1" /db_xref="EnsemblGenomes-Gn:BSU26990" /db_xref="EnsemblGenomes-Tr:CAB14640" /db_xref="GOA:O06010" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG13779" /db_xref="UniProtKB/Swiss-Prot:O06010" /translation="MNPIIEYLTGMNVLTDQIIAMDLLISAKNGVRNYAMAATEAGTP EVKEVLIRHLEEALDMHEQLSSYMMEKGWYHPWNPDEQVKLNLKNIDTAIQLPTL*" /label="yraD CDS" gene 2190717..2191016 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /label="yraD gene" downshifts 2191007 /Source="Nicolas_upshifts" /id="D1378" /incds=0 /nref=11 /ntot=39 /MaxReadThrough="1.62449" /MaxDrop="3.8153" /score="-8.57687054" /energy="-10.7" /TU="NA" /idTUdmin="U2075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2191279..2191701) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 17962296, 19170879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 17962296, 19170879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulated by thiol-alkylation" /protein_id="NP_390578.2" /db_xref="EnsemblGenomes-Gn:BSU27000" /db_xref="EnsemblGenomes-Tr:CAB14642" /db_xref="GOA:O06008" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13777" /db_xref="UniProtKB/Swiss-Prot:O06008" /translation="MNIAQVAKQFGLTAATLRYYERVGLIPPVKRKDSGIRDYDEEDI KWIEFIKCMRNAGLSIEALIEYTTLFTEGDRTVEARKNILADERQRLIEKRKEIDETI KRLDTKIKDYDGKLRENEAKLKSRPKTESLHGSVEQRR*" /label="adhR CDS" gene complement(2191279..2191701) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /label="adhR gene" promotor_-35 2191699..2191702 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-35" promotor_-10 2191718..2191737 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-10" S_feature 2191733..2191883 /Source="Nicolas_S_feature" /locus_tag="new_2755836_2755986" /HighExp="Diami, dia15, dia5, H2O2, S8, Paraq, S5, G180, S6, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1016" upshifts 2191733 /Source="Nicolas_upshifts" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="upshifts" promotor_-10 complement(2191736..2191755) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2191743) /Source="Nicolas_upshifts" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2191769..2191776) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2191852..2191871) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-10" upshifts complement(2191860) /Source="Nicolas_upshifts" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="upshifts" CDS 2191884..2192078 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /EC_number="4.1.1.44" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17962296, 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxymuconolactone decarboxylase" /protein_id="YP_009513988.1" /db_xref="EnsemblGenomes-Gn:BSU27009" /db_xref="EnsemblGenomes-Tr:CAX52671" /db_xref="InterPro:IPR029032" /db_xref="UniProtKB/TrEMBL:C0H460" /translation="MANKHTAGREQLGEFAPKFAELHDDVLFGDIWAREEELSSRDRS MITVSALITDCFSAYKSGSF*" /label="yrzP CDS" gene 2191884..2192078 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /label="yrzP gene" promotor_-35 complement(2191886..2191893) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-35" promotor_-35 2192096..2192103 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-35" promotor_-10 2192119..2192138 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-10" upshifts 2192123 /Source="Nicolas_upshifts" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="upshifts" S_feature 2192124..2192208 /Source="Nicolas_S_feature" /locus_tag="new_2756227_2756311" /HighExp="LBGstat, dia15, Diami, LPhT, LBGtran, dia5, M40t90, Lbtran, H2O2, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.987, 0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1017" CDS 2192209..2193258 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase; carbonyl stressresponse" /protein_id="NP_390579.2" /db_xref="EnsemblGenomes-Gn:BSU27010" /db_xref="EnsemblGenomes-Tr:CAB14643" /db_xref="GOA:C0SPA5" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12562" /db_xref="UniProtKB/Swiss-Prot:C0SPA5" /translation="MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGIC HSDIHSAFDEWGGGIFPMVPGHEIAGVVTAVGTKVTKLAVGDRVGVGCFVDSCGECEY CLNAEEQFCTKGVVQTYNSVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLL CAGITTYSPLKHWNVGPGKKVAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEAL ELGANHYFATSDPATFTALAGRFDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKP DTYSVFSLIMGRRSIAGSLVGGIQETQEMLDFAAEHGIEPKIEVIGADQVDEAYERIL RSDVRYRFVIDISTL*" /label="adhA CDS" gene 2192209..2193258 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /label="adhA gene" promotor_-35 2193326..2193333 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2193348..2193367 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2193361 /Source="Nicolas_upshifts" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="upshifts" CDS 2193389..2193898 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12775685, 17257049, 17933887, 24330391, 26774339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deglycase; general stress protecting enzyme; protects against methylglyoxal toxicity" /protein_id="NP_390580.2" /db_xref="EnsemblGenomes-Gn:BSU27020" /db_xref="EnsemblGenomes-Tr:CAB14644" /db_xref="GOA:O06006" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13776" /db_xref="UniProtKB/Swiss-Prot:O06006" /translation="MSKKIAVLVTDQFEDIEYTSPVKAYEEAGYSVVAIDLEAGKEVT GKHGEKVKIDKAISDVDASDFDALLIPGGFSPDLLRADDRPGEFAKAFVENKKPVFAI CHGPQVLIDTDLLKGKDITGYRSIRKDLINAGANYKDAEVVVSHNIVTSRTPDDLEAF NRESLNLLK*" /label="sufL CDS" gene 2193389..2193898 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /label="sufL gene" downshifts 2193867 /Source="Nicolas_upshifts" /id="D1379" /incds=0 /nref=178 /ntot=254 /MaxReadThrough="4.08169" /MaxDrop="5.1444" /score="24.8267602" /energy="-16.3" /TU="U2080" /idTUdmin="U2076" /TUdmin=528 /isTUend="FALSE" /label="downshifts" S_feature 2193912..2195017 /Source="Nicolas_S_feature" /locus_tag="new_2758015_2759120" /HighExp="Diami, dia5, Etha, dia15, LPhT, H2O2, Lbstat, Salt, Fru, Paraq" /AntisenseName="sacC" /AntisenseCor="0.18236909579254801" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.926" /label="S1018" CDS complement(2193940..2195973) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /EC_number="3.2.1.7" /EC_number="3.2.1.65" /EC_number="3.2.1.80" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7646030, 8057358, 10217495, 12224641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7646030, 8057358, 10217495, 12224641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levanase" /protein_id="NP_390581.1" /db_xref="EnsemblGenomes-Gn:BSU27030" /db_xref="EnsemblGenomes-Tr:CAB14645" /db_xref="GOA:P05656" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="PDB:4AZZ" /db_xref="PDB:4B1L" /db_xref="PDB:4B1M" /db_xref="SubtiList:BG10320" /db_xref="UniProtKB/Swiss-Prot:P05656" /translation="MKKRLIQVMIMFTLLLTMAFSADAADSSYYDEDYRPQYHFTPEA NWMNDPNGMVYYAGEYHLFYQYHPYGLQWGPMHWGHAVSKDLVTWEHLPVALYPDEKG TIFSGSAVVDKNNTSGFQTGKEKPLVAIYTQDREGHQVQSIAYSNDKGRTWTKYAGNP VIPNPGKKDFRDPKVFWYEKEKKWVMVLAAGDRILIYTSKNLKQWTYASEFGQDQGSH GGVWECPDLFELPVDGNPNQKKWVMQVSVGNGAVSGGSGMQYFVGDFDGTHFKNENPP NKVLWTDYGRDFYAAVSWSDIPSTDSRRLWLGWMSNWQYANDVPTSPWRSATSIPREL KLKAFTEGVRVVQTPVKELETIRGTSKKWKNLTISPASHNVLAGQSGDAYEINAEFKV SPGSAAEFGFKVRTGENQFTKVGYDRRNAKLFVDRSESGNDTFNPAFNTGKETAPLKP VNGKVKLRIFVDRSSVEVFGNDGKQVITDIILPDRSSKGLELYAANGGVKVKSLTIHP LKKVWGTTPFMSNMTGWTTVNGTWADTIEGKQGRSDGDSFILSSASGSDFTYESDITI KDGNGRGAGALMFRSDKDAKNGYLANVDAKHDLVKFFKFENGAASVIAEYKTPIDVNK KYHLKTEAEGDRFKIYLDDRLVIDAHDSVFSEGQFGLNVWDATAVFQNVTKES*" /label="sacC CDS" gene complement(2193940..2195973) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /label="sacC gene" downshifts complement(2193965) /Source="Nicolas_upshifts" /id="D1380" /incds=0 /nref=14 /ntot=60 /MaxReadThrough="0.56875" /MaxDrop="5.09923" /score="-2.07442916" /energy="-14.2" /TU="NA" /idTUdmin="U2081" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2195882..2196049) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513989.1" /translation="MPETDQLAQQSLLKVFKHEERSEGTNEKETDSSHDHVHPAVDYG IFGRCSRFKLL*" /label="hypothetical protein CDS" gene complement(2195882..2196049) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /label="gene" S_feature complement(2195974..2196129) /Source="Nicolas_S_feature" /locus_tag="new_2760077_2760232_c" /HighExp="UNK1, Fru, B60, T0.30H, M40t90, M0t90, ferm, LPh, GM-0.2, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.886" /TUlongSig="NA" /TUlongPSig="NA" /label="S1019" CDS complement(2196130..2196957) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IID component" /protein_id="NP_390582.1" /db_xref="EnsemblGenomes-Gn:BSU27040" /db_xref="EnsemblGenomes-Tr:CAB14646" /db_xref="GOA:P26382" /db_xref="InterPro:IPR004704" /db_xref="SubtiList:BG10319" /db_xref="UniProtKB/Swiss-Prot:P26382" /translation="MEKEKRLTKKEIFSMFIRSNFLLGSFNFERVQAMGYCYVMIPAI KKLYGPGAKRNEALQRHLEWFNTHPWLTAPIFGVTAAMEEEMANNKGIDGKAISGMKI GLMGPIAGVGDPIFWGTIRPVLAALGASLALGGNIAGPLLFFFLLNAIRLSTKYYGLK YGYVKGMEILQDLAGNRIQKLTEGASILGLFVMGALVSKWTTINIPIVVSRIKDESGK VDVQTVQNVLDSIMPGALPLGLTLLVAWMLRKGVNPLLIICGIFVIGILGYWAGFLA* " /label="levG CDS" gene complement(2196130..2196957) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /label="levG gene" CDS complement(2196978..2197787) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIC component" /protein_id="NP_390583.1" /db_xref="EnsemblGenomes-Gn:BSU27050" /db_xref="EnsemblGenomes-Tr:CAB14647" /db_xref="GOA:P26381" /db_xref="InterPro:IPR004700" /db_xref="SubtiList:BG10318" /db_xref="UniProtKB/Swiss-Prot:P26381" /translation="MSSLQIILLLIIAAITGIASVLDEGQTHRPLVACTLVGLVLGDL KTGIILGGTLELMALGWMNVGLAMAPDTAIASVISTILVITADQGIGEGIAVAVALAA AGQALTIFVRTITVFFIHRADQYAKAGNIKGIEIMHITAMVFQALRVMIPTLIVALIS VSAVQAFLGNIPDVITKGLQIGGGIIVVVGYAMVINMMNIPYLKPFFYIGFLLAAFTD FNLVGFGALGLCLALLYQQVMQKQSAHGAVAAASDSGSVAVYDDDDDDLDA*" /label="levF CDS" gene complement(2196978..2197787) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /label="levF gene" CDS complement(2197804..2198292) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /EC_number="2.7.1.202" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 9622354, 10589728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 9622354, 10589728; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIB component" /protein_id="NP_390584.1" /db_xref="EnsemblGenomes-Gn:BSU27060" /db_xref="EnsemblGenomes-Tr:CAB14648" /db_xref="GOA:P26380" /db_xref="InterPro:IPR004720" /db_xref="InterPro:IPR018455" /db_xref="InterPro:IPR036667" /db_xref="PDB:1BLE" /db_xref="SubtiList:BG10317" /db_xref="UniProtKB/Swiss-Prot:P26380" /translation="MNIVLARIDDRFIHGQILTRWIKVHAADRIIVVSDDIAQDEMRK TLILSVAPSNVKASAVSVSKMAKAFHSPRYEGVTAMLLFENPSDIVSLIEAGVPIKTV NVGGMRFENHRRQITKSVSVTEQDIKAFETLSDKGVKLELRQLPSDASEDFVQILRNV TK*" /label="levE CDS" gene complement(2197804..2198292) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /label="levE gene" CDS complement(2198292..2198732) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /EC_number="2.7.1.202" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIA component" /protein_id="NP_390585.1" /db_xref="EnsemblGenomes-Gn:BSU27070" /db_xref="EnsemblGenomes-Tr:CAB14649" /db_xref="GOA:P26379" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR013789" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10316" /db_xref="UniProtKB/Swiss-Prot:P26379" /translation="MISVIISGHGDFPIALKESSGMIFGEENNLIAVPFFKGEGIQTL QEKYHQALKDIPEEHEVLFLVDIFGGTPYNAAASFIAEDQRMDMAAGVNLPILLEVLS LREHLALKDLLNNLKAMSQQSFQVCSEHLEKVKTANQDTREDEL*" /label="levD CDS" gene complement(2198292..2198732) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /label="levD gene" downshifts 2198729 /Source="Nicolas_upshifts" /id="D1381" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="0.496260000000001" /MaxDrop="4.58461" /score="24.8267602" /energy="-16.3" /TU="NA" /idTUdmin="U2080" /TUdmin=3740 /isTUend="FALSE" /label="downshifts" misc_feature complement(2198769..2198787) /Source="Nicolas_upshift_promotors" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2198773) /Source="Nicolas_upshifts" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2198922..2201729) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NifA/NtrC family)" /protein_id="NP_390586.2" /db_xref="EnsemblGenomes-Gn:BSU27080" /db_xref="EnsemblGenomes-Tr:CAB14650" /db_xref="GOA:P23914" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10677" /db_xref="UniProtKB/Swiss-Prot:P23914" /translation="MRRIDKIYHQLKHNFHDSTLDHLLKIQGNSAKEIAEQLKMERSN VSFELNNLVRSKKVIKIKTFPVRYIPVEIAEKLFNKKWDTEMMEVKDLQAFSGNSKQN HQHISTNPLELMIGAKGSLKKAISQAKAAVFYPPNGLHMLLLGPTGSGKSLFANRIYQ FAIYSDILKAGAPFITFNCADYYNNPQLLLSQLFGHKKGSFTGAAEDKAGLVEQANGG ILFMDEIHRLPPEGQEMLFYFIDSGSYNRLGESEHKRTSNVLFICATTENPSSALLKT FLRRIPMTIHIPSLEERSLNERVDLTTFLLGKEAERIKKNLSVHIDVYNALIHSAKFG NVGQLKSNVQLVCAHGFLHNLDRNEVIELTVRDLPDEIKQEWMSSSKNMQRSKAISEY VNITTIISPIVEDETTKIDEDLSFNLYHLIEEKVKTLMKEGLSKKDINQYILTDVHLH VRSFFHHQAFQKDNLLTFVEDDVIQMTKQLKEIAEHELDCTFDRKFIYFLSMHIDAFL KRGKQIDVLNTQETDEIRDTHVKEYRVAMIFKDKIQEYFKVAIPEIEVIYLTMLIHSI KSLKENKRVGIIVAAHGNSTASSMVEVATELLGSTPIAAVDMPLTVSPSDILECVAEK MKQVDEGEGVLMLVDMGSLAMLESRLEEKTGISIKTISNVTTSMVLDAVRKVNYLNLN LHAIYQSVTKDFIELWERQPAASGKKKALVSICTTGSGTAKKLEDILTTIVNKASDTP IHILTVSSIKLANSIKEIEKEYEILATVGTKDPKINAPHVSLEVLIEGEGEKLIQQAI TKGSISLSNGLNEANIIVRELCEDSLKKYLVFLNPHHVIDMLLEWLQTVQDELGVIFN NAVLIKVIMHTAFAFERVIKQNPIAFSEEEEINDQLKEMVYVTERTLAPYEEKLGLRI SDDEKLFIAAIFAEEVHGQLF*" /label="levR CDS" gene complement(2198922..2201729) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /label="levR gene" misc_feature complement(2201945..2201964) /Source="Nicolas_upshift_promotors" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2201951) /Source="Nicolas_upshifts" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="upshifts" CDS 2202276..2202416 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513990.1" /translation="MTFLFYSAIQVESRVKNRATRHVTALKIVLKFKNKSIYSFKCYN IR*" /label="hypothetical protein CDS" gene 2202276..2202416 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /label="gene" misc_feature 2202397..2202416 /Source="Nicolas_upshift_promotors" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2202407 /Source="Nicolas_upshifts" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="upshifts" CDS 2202455..2203843 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17608695, 22084243; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small amino acid permease" /protein_id="NP_390587.2" /db_xref="EnsemblGenomes-Gn:BSU27090" /db_xref="EnsemblGenomes-Tr:CAB14651" /db_xref="GOA:O06005" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12556" /db_xref="UniProtKB/Swiss-Prot:O06005" /translation="MIGNSSKDNFGQQQKLSRGLKNRHIQLMAIGGAIGTGLFLGSGK SIHFAGPSILFAYLITGVFCFFIMRSLGELLLSNAGYHSFVDFVRDYLGNMAAFITGW TYWFCWISLAMADLTAVGIYTQYWLPDVPQWLPGLLALIILLIMNLATVKLFGELEFW FALIKVIAILALIVTGILLIAKGFSAASGPASLNNLWSHGGMFPNGWHGFILSFQMVV FAFVGIELVGLTAGETENPQKVIPKAINQIPVRILLFYVGALFVIMCIYPWNVLNPNE SPFVQVFSAVGIVVAASLINFVVLTSAASAANSALFSTSRMVYSLAKDHHAPGLLKKL TSSNVPSNALFFSSIAILIGVSLNYLMPEQVFTLITSVSTICFIFIWGITVICHLKYR KTRQHEAKANKFKMPFYPLSNYLTLAFLAFILVILALANDTRIALFVTPVWFVLLIIL YKVQTRRGHKVK*" /label="aapA CDS" gene 2202455..2203843 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /label="aapA gene" downshifts 2203832 /Source="Nicolas_upshifts" /id="D1382" /incds=0 /nref=7 /ntot=120 /MaxReadThrough="0.96985" /MaxDrop="3.54068" /score="11.8049306" /energy="-13" /TU="NA" /idTUdmin="U2083" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(2203865..2203938) /Source="Nicolas_S_feature" /locus_tag="new_2767968_2768041_c" /HighExp="MG 120, LBGstat, MG 150, MG 90, S0, HPh, HiOs, GM-0.1, aero, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1020" downshifts complement(2203907) /Source="Nicolas_upshifts" /id="D1383" /incds=0 /nref=11 /ntot=121 /MaxReadThrough="1.79954" /MaxDrop="4.59487" /score="37.881034" /energy="-13" /TU="NA" /idTUdmin="U2084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2203939..2204571) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16098526, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_390588.1" /db_xref="EnsemblGenomes-Gn:BSU27100" /db_xref="EnsemblGenomes-Tr:CAB14652" /db_xref="GOA:O05406" /db_xref="InterPro:IPR001123" /db_xref="InterPro:IPR004778" /db_xref="SubtiList:BG12304" /db_xref="UniProtKB/Swiss-Prot:O05406" /translation="MHSLLAYIPIAAMMVIIPGADTMLVMKNTLRYGPKAGRYNILGL ATGLSFWTVIAILGLSVVIAKSVILFTTIKYLGAAYLIYLGVKSFFAKSMFSLDDMQS QAKNMASSPKRYYKTSFMQGSLSNILNPKTVLVYVTIMPQFINLNGNINQQLIILASI LTLLAVLWFLFLVYIIDYAKKWMKNSKFQKVFQKITGIILVGFGIKTGLS*" /label="yrhP CDS" gene complement(2203939..2204571) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /label="yrhP gene" downshifts complement(2203995) /Source="Nicolas_upshifts" /id="D1384" /incds=0 /nref=4 /ntot=132 /MaxReadThrough="4.46187" /MaxDrop="3.11632" /score="37.881034" /energy="-13" /TU="U2084" /idTUdmin="U2084" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2204625..2204644) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2204636) /Source="Nicolas_upshifts" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2204650..2204656 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2204659..2204666) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2204670..2204689 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2204675 /Source="Nicolas_upshifts" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="upshifts" CDS 2204724..2205551 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator controlling amino acid export" /protein_id="NP_390589.1" /db_xref="EnsemblGenomes-Gn:BSU27110" /db_xref="EnsemblGenomes-Tr:CAB14653" /db_xref="InterPro:IPR002831" /db_xref="InterPro:IPR021586" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12303" /db_xref="UniProtKB/Swiss-Prot:O05405" /translation="MKENMLDILKNLNFTEYESKAYLALLQESPLTGYAVAKKSGVPR SKIYEVLESLVIRGDVFVSHGNTPQYVPVPAKELIKNRRLKAEEHFDQAEKYFEKFEQ TANDRENIWNITGRSEILEKVKACILSAKKRILLEIWKEDFKEIEAELKQAAEQGVIV TIIAYGDIVSDFANVYLHDMSSEITEEYDGRWLVYSGDDSEVVAGIVSLGNDSRAAWT MHVGLVMPITEVIIHDLYLMEILKKHRELLEESFGKNLIQLRRKFSIHSDFKKHYLE* " /label="yrhO CDS" gene 2204724..2205551 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /label="yrhO gene" downshifts 2205547 /Source="Nicolas_upshifts" /id="D1385" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="0.74814" /MaxDrop="5.12635" /score="6.64108595" /energy="-9.5" /TU="NA" /idTUdmin="U2085" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2205664..2205673 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2205686..2205701 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2205691 /Source="Nicolas_upshifts" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="upshifts" CDS 2205747..2206247 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 21926231, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 21926231, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V))" /protein_id="NP_390590.1" /db_xref="EnsemblGenomes-Gn:BSU27120" /db_xref="EnsemblGenomes-Tr:CAB14654" /db_xref="GOA:O05404" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11974" /db_xref="UniProtKB/Swiss-Prot:O05404" /translation="MKKKQTTKALLVTCITDHKQDFYRLAFSYVKNQDDALDIVQESI KKALSSVETVRNPETIKSWFYKILVRTAIDFLRKQKKIRVMDDETIEFLSKGKEDHYK DTDLHEALDELPYRYKTIIILRFFEDLKLEEIAEITGENTNTVKTRLYRALKLMRIQL TKEDLS*" /label="sigV CDS" gene 2205747..2206247 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /label="sigV gene" CDS 2206247..2207104 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(V) factor" /protein_id="NP_390591.1" /db_xref="EnsemblGenomes-Gn:BSU27130" /db_xref="EnsemblGenomes-Tr:CAB14655" /db_xref="GOA:O05403" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="PDB:5JEN" /db_xref="SubtiList:BG12302" /db_xref="UniProtKB/Swiss-Prot:O05403" /translation="MDKRLQQLREEYKNVQIPKELDIIVEKALQQEPKKKRIVMWPTS AAIAAAILFTALVNINPDAAQAMSKIPVIGKIVKAITFIEIKEEKDQSSIDVKTPALS GLSNKELENSINEKYLKESQQLYKEFIQSTSKNKKGHLSIYSDYETVTDTPDLLSIRR NIETTQASSYTQSRYITIDKKNDILLTLKSLFKDERYIKVISQNIKEQMKQQMKEDPN KIYWLTDEDAEPFKTILPDQTFYITEDHKLVISFDEYEVAPGYMGVTEFTIPTGVISN LLVGERYIR*" /label="rsiV CDS" gene 2206247..2207104 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /label="rsiV gene" promotor_-10 complement(2207122..2207133) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2207141) /Source="Nicolas_upshifts" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2207148..2207154) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2207215..2209119 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1521192, 15661003, 21135105, 21586574, 21856855, 21926231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1521192, 15661003, 21135105, 21586574, 21856855, 21926231; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan O-acetyltransferase" /protein_id="NP_390592.1" /db_xref="EnsemblGenomes-Gn:BSU27140" /db_xref="EnsemblGenomes-Tr:CAB14656" /db_xref="GOA:O05402" /db_xref="InterPro:IPR002656" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12301" /db_xref="UniProtKB/Swiss-Prot:O05402" /translation="MYHKTQHHRYIPGLDGLRAFAVLSVITYHLNFNWANGGFIGVDI FFVLSGYLITSILLPAYGNDINLDFRDFWVRRIRRLLPAAYLMIFSTVVWVVLFDREL LHTVRGDAISSLFYMSNWWFIFHKLSYFDSFGSPSPLKNLWSLAIEEQFYIIWPMFLV VGMYIMKSRARLAAVISLLVLCSAVMMSVLYEPGGDPSRVYYGTDTRSFELLIGCALA LVWPMKRLSSNRLPSKLKHTLHATEFLAFCILVLCVYFTDEYEPFLYRGGMLFISVTA AILIACVCHPSSFLGNLLSWRPLRWLGTRSYGIYLWHYPVIVLSTPVQEIGNPVFWHI VLKVIVTCILAELSYHFIEKPIRTQGFRSFSRRVFIHRIKEWKTTSVISKMSIGFIIF AILIFAGGLSGLAGEQKHPTKWTYSSQETNADTSQASGDKKNAAADKKHNPEQKTTDS NQGQKENKDSGQETHKKKDTQSQQLKKPADTAKEVLAIGDSVMLDISSHLRQSFSNVT IDGKVGRQMSQALELAREYKSFNQPNKAVIIELGTNGYFTNSQIEQLLQSFSKAHIYL VNTRVPRQWESKVNESLQQQAHAHQNVTLVDWHTEALQHPEYFTPDGVHLVPKGAKTL TALIVQAMKS*" /label="oatA CDS" gene 2207215..2209119 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /label="oatA gene" promotor_-35 2209200..2209206 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2209222..2209240 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2209228 /Source="Nicolas_upshifts" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="upshifts" CDS 2209253..2209543 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390593.1" /db_xref="EnsemblGenomes-Gn:BSU27150" /db_xref="EnsemblGenomes-Tr:CAB14657" /db_xref="GOA:O05401" /db_xref="InterPro:IPR025424" /db_xref="SubtiList:BG12300" /db_xref="UniProtKB/Swiss-Prot:O05401" /translation="MKGNEEHDIQKELKRYELFFKKRYKVLYTVNDFIIGAMFLVGSF FFFYDRLMSAGIWLFAIGSLLLLIRPTIRLIHDFHYRKHVEQQFKHQSSTDD*" /label="yrhK CDS" gene 2209253..2209543 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /label="yrhK gene" S_feature 2209544..2209659 /Source="Nicolas_S_feature" /locus_tag="new_2773647_2773762" /HighExp="Etha, Salt, LPhT, HiTm, G135, LBGstat, G180, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1021" promotor_-35 2209641..2209648 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2209661..2209786 /Source="Nicolas_S_feature" /locus_tag="new_2773764_2773889" /HighExp="Gly, G/S, Lbstat, C90, Pyr, LPhT, LoTm, Etha, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1022" upshifts 2209661 /Source="Nicolas_upshifts" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2209662..2209680 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2209680..2209780 /gene="surF" /locus_tag="BSU_misc_RNA_82" /product="small untranslated RNA expressed under sporulation conditions (SurF-AbrB)" /experiment="publication(s) with functional evidences, PMID:20709900, 25790031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 25790031; Product type n: RNA" /label="surF RNA" gene 2209680..2209780 /gene="surF" /locus_tag="BSU_misc_RNA_82" /label="surF gene" downshifts 2209743 /Source="Nicolas_upshifts" /id="D1386" /incds=0 /nref=7 /ntot=129 /MaxReadThrough="3.60641" /MaxDrop="5.24336" /score="25.0079309" /energy="-15.8" /TU="U2089" /idTUdmin="U2088" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(2209787..2212951) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /EC_number="1.14.14.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11574077, 12775685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077, 12775685; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP102A3" /protein_id="NP_390594.1" /db_xref="EnsemblGenomes-Gn:BSU27160" /db_xref="EnsemblGenomes-Tr:CAB14658" /db_xref="GOA:O08336" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12299" /db_xref="UniProtKB/Swiss-Prot:O08336" /translation="MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT VKPRKTAAINVQRKEQADIKAETKPKETKPKHGTPLLVLFGSNLGTAEGIAGELAAQG RQMGFTAETAPLDDYIGKLPEEGAVVIVTASYNGAPPDNAAGFVEWLKELEEGQLKGV SYAVFGCGNRSWASTYQRIPRLIDDMMKAKGASRLTAIGEGDAADDFESHRESWENRF WKETMDAFDINEIAQKEDRPSLSITFLSEATETPVAKAYGAFEGIVLENRELQTAAST RSTRHIELEIPAGKTYKEGDHIGILPKNSRELVQRVLSRFGLQSNHVIKVSGSAHMAH LPMDRPIKVVDLLSSYVELQEPASRLQLRELASYTVCPPHQKELEQLVSDDGIYKEQV LAKRLTMLDFLEDYPACEMPFERFLALLPSLKPRYYSISSSPKVHANIVSMTVGVVKA SAWSGRGEYRGVASNYLAELNTGDAAACFIRTPQSGFQMPNDPETPMIMVGPGTGIAP FRGFIQARSVLKKEGSTLGEALLYFGCRRPDHDDLYREELDQAEQDGLVTIRRCYSRV ENEPKGYVQHLLKQDTQKLMTLIEKGAHIYVCGDGSQMAPDVERTLRLAYEAEKAASQ EESAVWLQKLQDQRRYVKDVWTGM*" /label="cypB CDS" gene complement(2209787..2212951) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /label="cypB gene" downshifts complement(2209803) /Source="Nicolas_upshifts" /id="D1387" /incds=0 /nref=25 /ntot=213 /MaxReadThrough="2.3596" /MaxDrop="4.0425" /score="-9.99429269" /energy="-17.6" /TU="NA" /idTUdmin="U2091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2210937..2210946 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2210960..2210979 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2210981 /Source="Nicolas_upshifts" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2212967..2213551) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11574077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for cypB" /protein_id="NP_390595.1" /db_xref="EnsemblGenomes-Gn:BSU27170" /db_xref="EnsemblGenomes-Tr:CAB14659" /db_xref="GOA:O08335" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR032551" /db_xref="SubtiList:BG12298" /db_xref="UniProtKB/Swiss-Prot:O08335" /translation="MISASSSKYDMIMKASVSLFTERGFDATTIPMIAERAHVGTGTI YRYFDSKETLVNVLFQESIQRFTEKLKQDVSELPVREGFHHVFCCLVQFTKESDYALF FLETKKDAHYLNHTSKKMIENLTQMLDDYFNKGKAEGVIRSLPSNVLIAIVLGAFLKI YQLVQTGDIEMDTDLITELEQCCWDAIKLHSSQK*" /label="bscR CDS" gene complement(2212967..2213551) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /label="bscR gene" CDS complement(2213774..2214316) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390596.1" /db_xref="EnsemblGenomes-Gn:BSU27180" /db_xref="EnsemblGenomes-Tr:CAB14660" /db_xref="GOA:O05400" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12297" /db_xref="UniProtKB/Swiss-Prot:O05400" /translation="MLENRLYKRSDFWKLFSRKYKLTKTIEHMMIDSIDIQENDRILE IGIGNGTVFKSITKKLKKGSLKSIDPSKRKVRQISRANRKNMGNGEVFHGYPEDIPFD DRTFNKVFSLHTVQSCTDIRLALREIYRVLQIDGRFYISIDTNTGEKEKTYIQLLKDQ HFRDLSVIRRASCLCIVAVK*" /label="yrhH CDS" gene complement(2213774..2214316) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /label="yrhH gene" S_feature complement(2214317..2214402) /Source="Nicolas_S_feature" /locus_tag="new_2778420_2778505_c" /HighExp="T-0.40H, Salt, T0.30H, Heat, T0.0H, Etha, T-1.10H, T-1.40H, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1023" promotor_-10 complement(2214400..2214415) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2214402) /Source="Nicolas_upshifts" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2214428..2214437) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2214471..2214687) /Source="Nicolas_S_feature" /locus_tag="new_2778574_2778790_c" /HighExp="S7, S8, S6, LPhT, BT, LBGstat, S5, B36, G/S, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99909999999999999" /TUshortSig="SigK, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1024" CDS complement(2214505..2214663) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513991.1" /translation="MMNDYQKRLPSIGHGYASMPHSFKHGYGNPFRQQRLMAMQQQRL YVFPYHWH*" /label="hypothetical protein CDS" gene complement(2214505..2214663) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /label="gene" downshifts complement(2214514) /Source="Nicolas_upshifts" /id="D1388" /incds=0 /nref=34 /ntot=184 /MaxReadThrough="3.04168" /MaxDrop="7.65849" /score="23.6695072" /energy="-11.3" /TU="U2093" /idTUdmin="U2092" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2214685..2214704) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2214687) /Source="Nicolas_upshifts" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2214689..2214819) /Source="Nicolas_S_feature" /locus_tag="new_2778792_2778922_c" /HighExp="S7, S8, LPhT, S6, LBGstat, B36, BT, S5, Cold, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.893648" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1025" promotor_-35 complement(2214718..2214727) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2214820..2214969) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390597.1" /db_xref="EnsemblGenomes-Gn:BSU27190" /db_xref="EnsemblGenomes-Tr:CAB14661" /db_xref="InterPro:IPR012655" /db_xref="SubtiList:BG13819" /db_xref="UniProtKB/Swiss-Prot:O32027" /translation="MTINLFFLTLTIKKRFKSLEEFEREQQIEQIYDEMKESQLKHLY LTNWR*" /label="yrzI CDS" gene complement(2214820..2214969) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /label="yrzI gene" downshifts 2214963 /Source="Nicolas_upshifts" /id="D1389" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="1.96539" /MaxDrop="3.70444" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=4972 /isTUend="FALSE" /label="downshifts" S_feature complement(2214970..2215060) /Source="Nicolas_S_feature" /locus_tag="new_2779073_2779163_c" /HighExp="S7, LBGstat, Cold, S6, B36, LPhT, T-0.40H, LoTm, S8, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1026" S_feature complement(2215062..2215281) /Source="Nicolas_S_feature" /locus_tag="new_2779165_2779384_c" /HighExp="B60, B36, S7, BT, LBGstat, Cold, LoTm, LPhT, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52109300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1027" downshifts complement(2215105) /Source="Nicolas_upshifts" /id="D1390" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="7.23426" /MaxDrop="3.6023" /score="11.9275075" /energy="-19.6" /TU="U2093,U2094" /idTUdmin="U2094" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" downshifts 2215227 /Source="Nicolas_upshifts" /id="D1391" /incds=0 /nref=16 /ntot=94 /MaxReadThrough="0.94778" /MaxDrop="4.28987" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=5236 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2215260..2215279) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2215281) /Source="Nicolas_upshifts" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2215283..2215358) /Source="Nicolas_S_feature" /locus_tag="new_2779386_2779461_c" /HighExp="Lbexp, dia0, dia5, G150, Cold, C30, Mt0, LBGexp, dia15, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115567" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1028" promotor_-35 complement(2215294..2215301) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2215359..2216159) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 24887098; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative formate/nitrite transporter" /protein_id="NP_390598.1" /db_xref="EnsemblGenomes-Gn:BSU27200" /db_xref="EnsemblGenomes-Tr:CAB14662" /db_xref="GOA:O05399" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG12296" /db_xref="UniProtKB/Swiss-Prot:O05399" /translation="MAFRKPDEIAEAAIEAGMKKIKLPLPSLLVLGFLGGAFIALGYL LDIRVIGDLPKEWGSLSSLIGAAVFPVGLILVVLAGAELITGNMMSVAMALFSRKISV KELAINWGIVTIMNLIGALFVAYFFGHLVGLTETGPYLEKTIAVAQGKLDMSFGKVLI SAIGCNWLVCLAVWLSFGAQDAAGKILGIWFPIMAFVAIGFQHVVANMFVIPAAIFAG SFTWGQFIGNIIPAFIGNVIGGAVFVGLIYFIAYHKKDRSRKEMKQVS*" /label="yrhG CDS" gene complement(2215359..2216159) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /label="yrhG gene" S_feature complement(2216228..2216381) /Source="Nicolas_S_feature" /locus_tag="new_2780331_2780484_c" /HighExp="Lbexp, dia0, dia5, Cold, G150, Etha, HiOs, Salt, C90, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1029" downshifts complement(2216271) /Source="Nicolas_upshifts" /id="D1392" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="6.01922" /MaxDrop="3.7673" /score="23.461824" /energy="-25" /TU="U2094,U2095" /idTUdmin="U2095" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2216372..2216391) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-10" upshifts complement(2216381) /Source="Nicolas_upshifts" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="upshifts" promotor_-35 complement(2216406..2216412) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-35" CDS complement(2216422..2216790) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390599.1" /db_xref="EnsemblGenomes-Gn:BSU27210" /db_xref="EnsemblGenomes-Tr:CAB14663" /db_xref="InterPro:IPR018745" /db_xref="SubtiList:BG12295" /db_xref="UniProtKB/Swiss-Prot:O05398" /translation="MSKKIHEFNDIIRKLRKELFGKGPERIHTVFVENMAVSTLYGNL SASEQFIARTPEGREMVHAARTSLIQDLYSKQTPEGMEELMGAKLVHLFSDIKIEENI AVSVFVFDRKIDEQKEALQS*" /label="yrhF CDS" gene complement(2216422..2216790) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /label="yrhF gene" S_feature complement(2216791..2216887) /Source="Nicolas_S_feature" /locus_tag="new_2780894_2780990_c" /HighExp="T0.30H, LBGstat, T1.0H, T1.30H, G150, Lbexp, dia0, G180, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1030" promotor_-10 complement(2216873..2216892) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-10" promotor_-35 2216877..2216880 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2216893) /Source="Nicolas_upshifts" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="upshifts" promotor_-10 2216896..2216915 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2216898 /Source="Nicolas_upshifts" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="upshifts" S_feature 2216899..2217105 /Source="Nicolas_S_feature" /locus_tag="new_2781002_2781208" /HighExp="G150, Lbexp, dia0, Cold, dia5, G135, LBGstat, LBGexp, G180, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1031" promotor_-35 complement(2216908..2216912) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-35" CDS 2217106..2220048 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /EC_number="1.17.1.9" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913079, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative formate dehydrogenase" /protein_id="NP_390600.1" /db_xref="EnsemblGenomes-Gn:BSU27220" /db_xref="EnsemblGenomes-Tr:CAB14664" /db_xref="GOA:Q795Y4" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG12294" /db_xref="UniProtKB/Swiss-Prot:Q795Y4" /translation="MMDVKSISVRVDGTEIQARAGATILDILNENGIEYPQICHVPEV DPIQTCDTCIVEANGKLVRSCATVAENGMSIDLSGNRVKEAQTEAMDRLLENHLLYCT VCDNNNGNCTLHNTAEMMGIEHQKYPYTPKEDPSCAVDMSHPFYRYDPNQCIACGQCV EVCQNLQVNETLSIDWERERPRVIWDEGVPINESSCVSCGQCVTVCPCNALMEKSMLG QAGFMTGIKEDVMEPMIDLVKNVEPGYGSIFAISEVEAAMRETRTKKTKTVCTFCGVG CSFEVWTKGRDILKIQPVSDAPVNAISTCVKGKFGWDFVNSKERITKPLIRKNGAFVE SSWEEALDLVASRLGSIKEQYGKGSVGFISSSKITNEENYVIQKLARQVFETNNVDNC SRYCQSPATDGLFRTVGMGGDAGTIKDIAKAGLVIIVGANPAEGHPVLATRVKRAHKL HGQKLIVADLRKNEMAERSDLFISPKQGTDQVWLMAVTKYMIDQGWHDQAFIDENVNY FEDYKETLKTYTLDYAERITGLSKENIIQIAEMIRDADGTCVLWGMGVTQNTGGSDTS AAISNLLLATGNYRRPGAGAYPLRGHNNVQGACDMGTLPGWLPGYQHITDDKARAKFE EAYGVEIDGKPGLDNIQMLHAIEEGKMKAMYLVGEDMALVDSNANHVHDILSSLDFFV VQDIFLSRTAQYADVVLPATPSLEKDGTFTNTERRVQRLYQALPTLGDAKPDWWIIQE VANRLGANWNYSHPSDIFSEMASLSPLFAKASYEVLEGWNSFLWGSFTGESTPLLYED GFNFPDKKARFALSDWTEPAAFPEEYDLHINNGRMLEHFHEGNMTNKSKGIQAKVPNV FVEISPELAQERGVCDGSLVRLVSPFGAVKLNALITDRVRKNELYLPMNSTDKESAIN FLTGPAADKRTNTPAYKQTKVRMEVLGGCETAPLPKTNPRNKKRHPQNGVEAERKWNR PGYVHLTD*" /label="yrhE CDS" gene 2217106..2220048 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /label="yrhE gene" CDS 2220067..2220549 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10913079" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390601.1" /db_xref="EnsemblGenomes-Gn:BSU27230" /db_xref="EnsemblGenomes-Tr:CAB14665" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG12293" /db_xref="UniProtKB/Swiss-Prot:O05396" /translation="MATPITTIKKETKTAEQIKLEKIEELKELLAENEDAVSKTMTLM NELNDLGIFDAATSMLRAKEDIAKIALGQVSREPVTNLINTMMAAGGALTKADPEFTA KLLESVMAGTEQAQSFLKEDKKVGILDLLKAMNDPDINRAVGFGLQFLKGMGKELREQ *" /label="yrhD CDS" gene 2220067..2220549 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /label="yrhD gene" downshifts 2220529 /Source="Nicolas_upshifts" /id="D1393" /incds=0 /nref=65 /ntot=196 /MaxReadThrough="1.1227" /MaxDrop="6.19465" /score="27.8496451" /energy="-11.2" /TU="NA" /idTUdmin="U2096" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2220585..2220815) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17056751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390602.1" /db_xref="EnsemblGenomes-Gn:BSU27240" /db_xref="EnsemblGenomes-Tr:CAB14666" /db_xref="GOA:O05395" /db_xref="InterPro:IPR025418" /db_xref="SubtiList:BG12292" /db_xref="UniProtKB/Swiss-Prot:O05395" /translation="MNKNRMKSLKEDYKHFAFTLLAVSTFLYIGAVLPDQGLTLGQKS TMFLADCVFLAGAFFCADRSLIYKKRLEEADE*" /label="yrhC CDS" gene complement(2220585..2220815) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /label="yrhC gene" downshifts complement(2220605) /Source="Nicolas_upshifts" /id="D1394" /incds=0 /nref=60 /ntot=210 /MaxReadThrough="0.98344" /MaxDrop="5.84379" /score="15.2557797" /energy="-11.2" /TU="NA" /idTUdmin="U2097" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2220816..2220897) /Source="Nicolas_S_feature" /locus_tag="new_2784919_2785000_c" /HighExp="dia5, dia15, BT, Diami, B36, B60, nit, dia0, MG 10, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1032" CDS complement(2220898..2222037) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /EC_number="4.4.1.2" /EC_number="4.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway" /protein_id="NP_390603.1" /db_xref="EnsemblGenomes-Gn:BSU27250" /db_xref="EnsemblGenomes-Tr:CAB14667" /db_xref="GOA:O05394" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12291" /db_xref="UniProtKB/Swiss-Prot:O05394" /translation="MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEY SRTANPTRTALEALVTELESGEAGYAFSSGMAAITAVMMLFNSGDHVVLTDDVYGGTY RVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIA KKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEE LHFVQNSTGGVLGPQDSWLLMRGIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPG SSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTIAESLGAVESLISVPA RMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQALENI*" /label="mccB CDS" gene complement(2220898..2222037) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /label="mccB gene" CDS complement(2222039..2222962) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /EC_number="2.5.1.47" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-synthase for the reverse transsulfuration pathway" /protein_id="NP_390604.1" /db_xref="EnsemblGenomes-Gn:BSU27260" /db_xref="EnsemblGenomes-Tr:CAB14668" /db_xref="GOA:O05393" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG12290" /db_xref="UniProtKB/Swiss-Prot:O05393" /translation="MTVITDITELIGNTPLLRLKNFDVPEGVAVYAKLEMMNPGGSIK DRLGDMLIRDALDSGKVKPGGVIIEATAGNTGIGLALSARKYGLKAIFCVPEHFSREK QQIMQALGASIIHTPRQDGMQGAIQKAIQLETEIENSYCVLQFKNRVNPSTYYKTLGP EMWEALDGNIHTFVAGAGSGGTFAGTASFLKEKNPAVKTVIVEPVGSILNGGEPHAHK TEGIGMEFIPDYMDKSHFDEIYTVTDENAFRLVKEAAEKEGLLIGSSSGAALYAALEE AKKASAGTNIVTVFPDSSDRYISKQIYEGGI*" /label="mccA CDS" gene complement(2222039..2222962) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /label="mccA gene" downshifts complement(2222955) /Source="Nicolas_upshifts" /id="D1395" /incds=0 /nref=16 /ntot=178 /MaxReadThrough="7.13056" /MaxDrop="3.40819" /score="0.994445584" /energy="-8.7" /TU="U2097,U2098,U2099" /idTUdmin="U2102" /TUdmin=1874 /isTUend="FALSE" /label="downshifts" S_feature complement(2222963..2223026) /Source="Nicolas_S_feature" /locus_tag="new_2787066_2787129_c" /HighExp="dia5, Diami, dia15, BT, B36, S6, LBGstat, S8, dia0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1033" CDS complement(2223027..2223722) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /EC_number="3.2.2.9" /EC_number="3.2.2.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioadenosine / S-adenosylhomocysteine nucleosidase" /protein_id="NP_390605.1" /db_xref="EnsemblGenomes-Gn:BSU27270" /db_xref="EnsemblGenomes-Tr:CAB14669" /db_xref="GOA:O32028" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR010049" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG13800" /db_xref="UniProtKB/Swiss-Prot:O32028" /translation="MRLAVIGAMEEEVTILRNKLENAKTETIAHCEFTTGEYEGTEVI LLKSGIGKVNAAISTTLLLDRYKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDV TAFDYEYGQVPGLPAAYAADEKLISITEEAVSELDGIQVAKGTIATGDSFMNDPKRVE EVRARFSDLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESHVSFDQFLEQAAVH STELVLKVIKRIH*" /label="mtnN CDS" gene complement(2223027..2223722) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /label="mtnN gene" promotor_-10 complement(2223462..2223481) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2223480) /Source="Nicolas_upshifts" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2223494..2223503) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2223743..2224384) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 17056751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_390606.1" /db_xref="EnsemblGenomes-Gn:BSU27280" /db_xref="EnsemblGenomes-Tr:CAB14670" /db_xref="GOA:O32029" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023553" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13799" /db_xref="UniProtKB/Swiss-Prot:O32029" /translation="MGREFIPLFEDWAATYDQTVQGLDIQYKEAFRGYDHILDAIVRK SGTHVLEFGPGTGNLTAKLLDAGKTVFGIEPSPAMRKLASDKLSGRTEIVDGDFLTFP EPPFQADTIVSSYAFHHLTDEEKRAAIKQYGKYLHLHDKIVFADTVFENAQAYQQAID KARSQGFYQLANDLETEHYPTLDALKEMFTAEGFAVRFTQQNDFVWIMEAIKR*" /label="yrrT CDS" gene complement(2223743..2224384) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /label="yrrT gene" promotor_-10 complement(2223951..2223970) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2223970) /Source="Nicolas_upshifts" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2223987..2223990) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2224436..2224445 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2224442..2224461) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2224448) /Source="Nicolas_upshifts" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2224458..2224477 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2224467..2224531 /Source="Nicolas_S_feature" /locus_tag="new_2788570_2788634" /HighExp="BT, S6, S7, S8, S5, B36, G/S, Pyr, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1034" upshifts 2224467 /Source="Nicolas_upshifts" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2224477..2224480) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2224512..2224519 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2224533 /Source="Nicolas_upshifts" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2224535..2224552 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2224577..2224780 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390607.1" /db_xref="EnsemblGenomes-Gn:BSU27290" /db_xref="EnsemblGenomes-Tr:CAB14671" /db_xref="InterPro:IPR019686" /db_xref="SubtiList:BG13811" /db_xref="UniProtKB/Swiss-Prot:O32030" /translation="MNFQLDLIKDKVEFFEAASLQELEKKINTQIENNKAIMLRVKSV SHQTLVAEGRILYSAVVHFSAEA*" /label="yrzA CDS" gene 2224577..2224780 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /label="yrzA gene" downshifts 2224787 /Source="Nicolas_upshifts" /id="D1396" /incds=0 /nref=205 /ntot=257 /MaxReadThrough="1.11529" /MaxDrop="5.39095" /score="26.0850303" /energy="-14.2" /TU="NA" /idTUdmin="U2101" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2224817..2225518) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679248" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390608.1" /db_xref="EnsemblGenomes-Gn:BSU27300" /db_xref="EnsemblGenomes-Tr:CAB14672" /db_xref="GOA:O32031" /db_xref="InterPro:IPR009988" /db_xref="SubtiList:BG13798" /db_xref="UniProtKB/Swiss-Prot:O32031" /translation="MSNNQSRYENRDKRRKANLVLNILIAIVSILIVVVAANLFINSP SSKDVSKDSETAQKQESPASGKTEKKSDEDIKDSKKDTSDSEKDSEKSSDSDSKKDDS SSKKDDSDSDSSSDSAGDGLKDAKVTEGGSSSDVEKTYENPDWKAVGTEQTGEHAATY DSSSQDWAEMLKAISYATGVSTDNMTVLWLGNNGSPQDAKGKILDKATGNKYQVTITW VDEKGWKPTKVEKLK*" /label="yrrS CDS" gene complement(2224817..2225518) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /label="yrrS gene" downshifts complement(2224829) /Source="Nicolas_upshifts" /id="D1397" /incds=0 /nref=237 /ntot=265 /MaxReadThrough="1.64695" /MaxDrop="6.48551" /score="22.1367505" /energy="-14.2" /TU="NA" /idTUdmin="U2102" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2225583..2227337) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14679248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein PBP4B" /protein_id="NP_390609.1" /db_xref="EnsemblGenomes-Gn:BSU27310" /db_xref="EnsemblGenomes-Tr:CAB14673" /db_xref="GOA:O32032" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13797" /db_xref="UniProtKB/Swiss-Prot:O32032" /translation="MKISKRMKLAVIAFLIVFFLLLLRLAEIQLFFTESFSKKKINLI QESVKQRTEEVLISDGRGSFLDRNGRALTGQSEPAVVLFPFLLTQDWPIKKVADILGM SEDDLRQTLGQAKKPVILQQKKIKTLSKQSITKINSLKYPGIYGVYMENEDKPSLASH TIGSTNQDPALLRKKYPDKESLPITTEIGTTGLERTFDEFLLPEQDTKLLYHVDGKGN PLFGMDVKYTAEANTFYPLQIKTTIDQSIQKAMEEVLDEQGLKKGGAVLLDIENSSVL GIVSKPDADVSRQNTLQNYMLTPIYPGSVFKTVIAAAAIENNMVKPSQTFNCNLNLYG EPGDDKGTLSFDESFAQSCNYTFTSLAEQLMKKDSSVIEDMSEKLALTDRAGWEGKLY HETDFRQLYNEKSGVIWGDEKDKSVKKAIAQTAIGQKNVKVTPLEVANMMATIARGGE KRQVKIAEQIEYKNGTTLVTFKDQKLKGETIDKYTSQQLQKILRRVVESPSGTGRRFQ DLPYTVAGKSGTAQTGKLSKEKETLYEKWFAGYFPADKPKYALVVLHMDTPGDKALTN SVFYDIVKKVHEIEINQK*" /label="pbpI CDS" gene complement(2225583..2227337) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /label="pbpI gene" misc_feature complement(2225611..2225630) /Source="Nicolas_upshift_promotors" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2225621) /Source="Nicolas_upshifts" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2226652..2226667) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2226655) /Source="Nicolas_upshifts" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2226680..2226689) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2226883..2226901) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2226897) /Source="Nicolas_upshifts" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2226916..2226923 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2226916..2226921) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2226938..2226957 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2226943 /Source="Nicolas_upshifts" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2227391..2227864) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10910724, 16014871, 16707701, 21515770, 28976965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10910724, 16014871, 16707701, 21515770, 28976965; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription elongation factor resolving backtracking / stalling" /protein_id="NP_390610.1" /db_xref="EnsemblGenomes-Gn:BSU27320" /db_xref="EnsemblGenomes-Tr:CAB14674" /db_xref="GOA:P80240" /db_xref="InterPro:IPR001437" /db_xref="InterPro:IPR006359" /db_xref="InterPro:IPR018151" /db_xref="InterPro:IPR022691" /db_xref="InterPro:IPR023459" /db_xref="InterPro:IPR028624" /db_xref="InterPro:IPR036805" /db_xref="InterPro:IPR036953" /db_xref="SubtiList:BG19019" /db_xref="UniProtKB/Swiss-Prot:P80240" /translation="MAQEKVFPMTAEGKQKLEQELEYLKTVKRKEVVERIKIARSFGD LSENSEYDSAKEEQAFVEGRVTTLENMIRNAKIIEDDGGSNVVGLGKTVTFVELPDGD EESYTIVGSAEADPFEGKISNDSPIAKSLLGKKVDEEVTVQTPGGEMLVKIVKIS*" /label="greA CDS" gene complement(2227391..2227864) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /label="greA gene" downshifts complement(2227398) /Source="Nicolas_upshifts" /id="D1398" /incds=0 /nref=130 /ntot=229 /MaxReadThrough="5.30316" /MaxDrop="4.90519" /score="34.2316821" /energy="-17" /TU="U2107" /idTUdmin="U2106" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(2227865..2227997) /Source="Nicolas_S_feature" /locus_tag="new_2791968_2792100_c" /HighExp="HPh, C90, dia5, dia15, Diami, H2O2, dia0, Etha, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1035" promotor_-10 complement(2227979..2227998) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2227997) /Source="Nicolas_upshifts" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2227999..2228107) /Source="Nicolas_S_feature" /locus_tag="new_2792102_2792210_c" /HighExp="HPh, G180, G135, LBGexp, dia0, Paraq, Oxctl, G150, LPh, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1036" promotor_-35 complement(2228012..2228019) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2228100..2228119) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2228107) /Source="Nicolas_upshifts" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2228115..2228750) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /EC_number="2.7.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 6208029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridine kinase" /protein_id="NP_390611.1" /db_xref="EnsemblGenomes-Gn:BSU27330" /db_xref="EnsemblGenomes-Tr:CAB14675" /db_xref="GOA:O32033" /db_xref="InterPro:IPR000764" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR026008" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12696" /db_xref="UniProtKB/Swiss-Prot:O32033" /translation="MGKNPVVIGIAGGSGSGKTSVTRSIYEQFKGHSILMIQQDLYYK DQSHLPFEERLNTNYDHPLAFDNDYLIEHIQDLLNYRPIEKPIYDYKLHTRSEETVHV EPKDVIILEGILVLEDKRLRDLMDIKLYVDTDADLRIIRRIMRDINERGRSIDSVIEQ YVSVVRPMHNQFVEPTKRYADIIIPEGGQNHVAIDLMVTKIQTILEQNAIL*" /label="udk CDS" gene complement(2228115..2228750) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /label="udk gene" promotor_-35 complement(2228135..2228139) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2228245..2228250 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2228266..2228284 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2228273 /Source="Nicolas_upshifts" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2228757..2230025) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase large subunit" /protein_id="NP_390612.1" /db_xref="EnsemblGenomes-Gn:BSU27340" /db_xref="EnsemblGenomes-Tr:CAB14676" /db_xref="GOA:O32034" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032525" /db_xref="SubtiList:BG13796" /db_xref="UniProtKB/Swiss-Prot:O32034" /translation="MTAVNDKISTIVNGKRVITKKPELLAPAGNLEKLKIAVHYGADA VFIGGQEYGLRSNADNFTIEEIAEGVEFAKKYGAKIYVTTNIFAHNENMDGLEDYLKA LGDANVAGIIVADPLIIETCRRVAPNVEVHLSTQQSLSNWKAVQFWKEEGLDRVVLAR ETSALEIREMKEKVDIEIESFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDY DLYQTDGANAVALYGEEDAPFAMSPKDLKLIESIPKMIEMGIDSLKIEGRMKSIHYVA TVVSVYRKVIDAYCADPENFVIQKEWLEELDKCANRDTATAFFEGTPGYEEQMFGEHA KKTTYDFVGLVLNYDEDTQMVTLQQRNFFKKGDEVEFFGPEIENFTHTIETIWDEDGN ELDAARHPLQIVKFKLDKKIYPSNMMRKGK*" /label="yrrO CDS" gene complement(2228757..2230025) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /label="yrrO gene" CDS complement(2230044..2230973) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase small subunit" /protein_id="NP_390613.1" /db_xref="EnsemblGenomes-Gn:BSU27350" /db_xref="EnsemblGenomes-Tr:CAB14677" /db_xref="GOA:O32035" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG13795" /db_xref="UniProtKB/Swiss-Prot:O32035" /translation="MKKPELLVTPTSTADILPLIQAGATAFLVGEQRYGLRLAGEFSR EDVTKAVEIAHKEGAKVYVAVNAIFHNDKVGELGEYLAFLAEAGVDAAVFGDPAVLMA ARESAPDLKLHWSTETTGTNYYTCNYWGRKGAARSVLARELNMDSIVEIKENAEVEIE IQVHGMTCMFQSKRSLIGNYFEYQGKVMDIERKKKESGMFLHDKERDNKYPIFEDENG THIMSPNDVCIIDELEELIDAGIDSFKIDGVLKMPEYLIEVTKMYREAIDLCVENRDE YEAKKEDWIERIESIQPVNRKIDTGFFFKETVY*" /label="yrrN CDS" gene complement(2230044..2230973) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /label="yrrN gene" CDS complement(2230979..2231632) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /EC_number="2.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA O-methyltransferase" /protein_id="NP_390614.1" /db_xref="EnsemblGenomes-Gn:BSU27360" /db_xref="EnsemblGenomes-Tr:CAB14678" /db_xref="GOA:O32036" /db_xref="InterPro:IPR002935" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13794" /db_xref="UniProtKB/Swiss-Prot:O32036" /translation="MTDRYEQINDYIEALLKPRPDNVKRLEAYAEEHHVPIMEKAGME VLLQILSVKQPKKILEIGTAIGYSAIRMALELPSAEIYTIERNEKRHEEAVNNIKEFQ LDDRIHVFYGDALELADAVHVTAPYDVIFIDAAKGQYQNFFHLYEPMLSPDGVIITDN VLFKGLVAEDYSKIEPKRRRRLVAKIDEYNHWLMNHPDYQTAIIPVGDGLAISKKKR* " /label="yrrM CDS" gene complement(2230979..2231632) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /label="yrrM gene" S_feature complement(2231633..2231737) /Source="Nicolas_S_feature" /locus_tag="new_2795736_2795840_c" /HighExp="LBGexp, G180, H2O2, G150, Paraq, Oxctl, G135, dia15, C30, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1037" promotor_-10 complement(2231719..2231738) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2231737) /Source="Nicolas_upshifts" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2231754..2231758) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2231784..2232866) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved membrane associated protein" /protein_id="NP_390615.1" /db_xref="EnsemblGenomes-Gn:BSU27370" /db_xref="EnsemblGenomes-Tr:CAB14679" /db_xref="GOA:O34758" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13793" /db_xref="UniProtKB/Swiss-Prot:O34758" /translation="MYINQQKKSFFNKKRIILSSIVVLFLIIGGAFLYGKSLLEPVEK DSKTTVNINIPSGSSVSAIASILKKNDVIKSEKAFQYYVKYKGASGFQAGFYHLNKGM DLDAIIQKLTSGATGYAFQITVTEGAQLTQIAAAIADETKYSKKQVIAKLDDETFINQ LKKEFPDTVTNDVFNKNIKHPLEGYLFPATYPFNDPDTSLEDIIKAMIKQTNSYVETY KSEMKKNKVSVHKLLTMASLIEEEATEKADRHKIASVFYNRLKKKMPLQTDPTVLYAA GKHKDRVLYKDLEIDSPYNTYKNTGLTPGPIANAGMSSWEAALHPDKTDYLYFLAKSN GEVVFTKTLKEHNKAKEKYISSKNEK*" /label="yrrL CDS" gene complement(2231784..2232866) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /label="yrrL gene" downshifts complement(2231818) /Source="Nicolas_upshifts" /id="D1399" /incds=0 /nref=21 /ntot=144 /MaxReadThrough="3.5258" /MaxDrop="3.97301" /score="10.5327118" /energy="-11" /TU="U2110" /idTUdmin="U2111" /TUdmin=1173 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2232882..2232901) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2232902) /Source="Nicolas_upshifts" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2232916..2232919) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2232992) /Source="Nicolas_upshifts" /id="D1400" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="2.55298" /MaxDrop="6.9121" /score="36.0941054" /energy="-15" /TU="NA" /idTUdmin="U2111" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2232997..2233278) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_390616.1" /db_xref="EnsemblGenomes-Gn:BSU27380" /db_xref="EnsemblGenomes-Tr:CAB14680" /db_xref="InterPro:IPR009711" /db_xref="SubtiList:BG13812" /db_xref="UniProtKB/Swiss-Prot:O34828" /translation="MEHGEKNITIVDDQGNEQLCEVLFTFENEEFGKSYVLYYPIESK DDEEVEILASSFTPNEDGENGELFPIETDEEWDMIEETLNTFLADEDEE*" /label="yrzB CDS" gene complement(2232997..2233278) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /label="yrzB gene" downshifts complement(2233057) /Source="Nicolas_upshifts" /id="D1401" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.68915" /MaxDrop="5.19246" /score="36.0941054" /energy="-15" /TU="U2111,U2113,U2114,U2115" /idTUdmin="U2111" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2233296..2233712) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 14512736, 16021622, 22720735, 23251031, 25545592; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pre-16S ribosomal RNA maturation enzyme" /protein_id="NP_390617.1" /db_xref="EnsemblGenomes-Gn:BSU27390" /db_xref="EnsemblGenomes-Tr:CAB14681" /db_xref="GOA:O34634" /db_xref="InterPro:IPR005227" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR037027" /db_xref="PDB:1VHX" /db_xref="SubtiList:BG13792" /db_xref="UniProtKB/Swiss-Prot:O34634" /translation="MRILGLDLGTKTLGVALSDEMGWTAQGIETIKINEAEGDYGLSR LSELIKDYTIDKIVLGFPKNMNGTVGPRGEASQTFAKVLETTYNVPVVLWDERLTTMA AEKMLIAADVSRQKRKKVIDKMAAVMILQGYLDSLN*" /label="rimF CDS" gene complement(2233296..2233712) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /label="rimF gene" promotor_-10 complement(2233544..2233562) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2233563) /Source="Nicolas_upshifts" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2233578..2233583) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2233720..2233986) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_054589.1" /db_xref="EnsemblGenomes-Gn:BSU27400" /db_xref="EnsemblGenomes-Tr:CAE01464" /db_xref="InterPro:IPR009309" /db_xref="SubtiList:BG14184" /db_xref="UniProtKB/Swiss-Prot:Q7WY61" /translation="MSSFDKTMKFNFSDDSAETNVNEVLITVYDALQEKGYNPINQIV GYLLSGDPAYIPRHRDARNLIRKLERDELIEELVKSYLEQHKEA*" /label="yrzL CDS" gene complement(2233720..2233986) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /label="yrzL gene" promotor_-35 2233874..2233882 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2233897..2233916 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2233905..2235094 /Source="Nicolas_S_feature" /locus_tag="new_2798008_2799197" /HighExp="S6, C30, C90, S8, S7, Gly, G135, Fru, G180, M/G" /AntisenseName="alaS" /AntisenseCor="-0.27843994691040502" /AntisenseRegPval="-5.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1038" upshifts 2233905 /Source="Nicolas_upshifts" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2233987..2234047) /Source="Nicolas_S_feature" /locus_tag="new_2798090_2798150_c" /HighExp="LBGtran, LBGexp, G135, C90, G150, G180, LBGstat, Oxctl, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.994, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1039" promotor_-10 complement(2234041..2234060) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2234047) /Source="Nicolas_upshifts" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2234071..2236707) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /EC_number="6.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12554667, 12682299, 17329819, 22720735, 25918376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanyl-tRNA synthetase" /protein_id="NP_390618.1" /db_xref="EnsemblGenomes-Gn:BSU27410" /db_xref="EnsemblGenomes-Tr:CAB14682" /db_xref="GOA:O34526" /db_xref="InterPro:IPR002318" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018162" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR018164" /db_xref="InterPro:IPR018165" /db_xref="InterPro:IPR023033" /db_xref="SubtiList:BG12563" /db_xref="UniProtKB/Swiss-Prot:O34526" /translation="MKHLTSAEVRQMFLDFFKEKGHAVEPSASLVPHEDPSLLWINSG VATLKKYFDGRVVPENPRIVNAQKAIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKE EAITWAWEFLTSDKWIGFDKELLSVTVHPEDEEAYEFWAKKIGIPEERIIRLEGNFWD IGEGPSGPNTEIFYDRGEAYGNDPEDPELYPGGENDRYLEVWNLVFSEFNHNPDGTYT PLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESISGETYGKDNVKDTAFK VIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPFMFDLVPVVAE IMADFYPEVKEKADFIAKVIKTEEERFHETLNEGLAILSEMIKKEKDKGSSVISGADV FKLYDTYGFPVELTEEYAEDENMTVDHEGFEEEMNQQRERARNARQDVGSMQVQGGAL RDVTVESTFVGYSQTKADANIIVLLQDGQLIEEAHEGESVQIILDETPFYAESGGQIG DKGYLRSEQAVVRIKDVQKAPNGQHVHEGVVESGTVQKGLHVTAEVEDHMRSGVIKNH TATHLLHQALKDVLGTHVNQAGSLVTENRLRFDFSHFGQVTKEELEQIERIVNEKIWA SIPVSIDLKPIAEAKEMGAMALFGEKYGDIVRVVQVGDYSLELCGGCHVRNTAEIGLF KIVSESGIGAGTRRIEAVTGQGAYVEMNSQISVLKQTADELKTNIKEVPKRVAALQAE LKDAQRENESLLAKLGNVEAGAILSKVKEVDGVNVLAAKVNAKDMNHLRTMVDELKAK LGSAVIVLGAVQNDKVNISAGVTKDLIEKGLHAGKLVKQAAEVCGGGGGGRPDMAQAG GKQPEKLEEALASVEDWVKSVL*" /label="alaS CDS" gene complement(2234071..2236707) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /label="alaS gene" promotor_-35 complement(2234074..2234081) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2236473..2236491) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2236489) /Source="Nicolas_upshifts" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2236505..2236512) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2236708..2236786) /Source="Nicolas_S_feature" /locus_tag="new_2800811_2800889_c" /HighExp="G150, LBGexp, G135, G180, Oxctl, LBGtran, Lbexp, Paraq, dia15, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1040" misc_RNA complement(2236787..2236994) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /product="T-box riboswitch specific of alanine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboA RNA" gene complement(2236787..2236994) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /label="tboA gene" promotor_-10 complement(2237002..2237021) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2237017) /Source="Nicolas_upshifts" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2237036..2237043) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2237038..2238099) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_390619.1" /db_xref="EnsemblGenomes-Gn:BSU27420" /db_xref="EnsemblGenomes-Tr:CAB14683" /db_xref="GOA:O34472" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13791" /db_xref="UniProtKB/Swiss-Prot:O34472" /translation="MLQKPVQLLLWVAICLLVLLTVYVFFMLDMLWSPFWLVIKTIFI PLIISIFISYLLLPVTEWLHGKGLPRTLSILVIYVLFFGGIGWALYKGVPVLIVQLTD LSENIPMFAETYNGLLLHVHNHTDDWPDGMHHRIDKMIRQTEAFFAGTIEGAISGIRN VLDYFLIAATIPFLVFYMVKDIELMKKTVWYLTPKSWRKRGSAFLRDVDDSLGDYIRG QLLVCLILGVIAGISFWVFGLPYPLILGLISGVTNVIPYFGPFIGAVPALLIAMTISV KAVLVVVITVFILQFMEGNILSPFIVGRSLKMHPVVIMLALLAGGELAGIVGMILAVP ATAVLKVMMIHFLRMRTEH*" /label="yrrI CDS" gene complement(2237038..2238099) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /label="yrrI gene" promotor_-35 2238008..2238013 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2238019..2238254 /Source="Nicolas_S_feature" /locus_tag="new_2802122_2802357" /HighExp="S5, S6, S4, S8, S3, S7, LoTm, BT, M9-stat, T5.0H" /AntisenseName="yrrI" /AntisenseCor="0.71790030040923003" /AntisenseRegPval="-43.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1041" upshifts 2238020 /Source="Nicolas_upshifts" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2238029..2238047 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2238116..2238127) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2238117) /Source="Nicolas_upshifts" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2238141..2238147) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2238255..2238983 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (ATP-binding protein)" /protein_id="NP_390620.1" /db_xref="EnsemblGenomes-Gn:BSU27430" /db_xref="EnsemblGenomes-Tr:CAB14684" /db_xref="GOA:O34677" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11485" /db_xref="UniProtKB/Swiss-Prot:O34677" /translation="MITFQNVNKHYGDFHVLKQINLQIEKGEVVVIIGPSGSGKSTLL RCINRLESINEGVLTVNGTAINDRKTDINQVRQNIGMVFQHFHLYPHKTVLQNIMLAP VKVLRQSPEQAKETARYYLEKVGIPDKADAYPSQLSGGQQQRVAIARGLAMKPEVMLF DEPTSALDPEMIGEVLDVMKTLAKEGMTMVVVTHEMGFAKEVADRIVFIDEGKILEEA VPAEFYANPKEERARLFLSRILNH*" /label="glnQ CDS" gene 2238255..2238983 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /label="glnQ gene" downshifts complement(2238711) /Source="Nicolas_upshifts" /id="D1402" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="1.29649" /MaxDrop="3.29152" /score="-3.35464926" /energy="-5.4" /TU="NA" /idTUdmin="U2117" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" CDS 2239005..2239826 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (glutamine-binding lipoprotein)" /protein_id="NP_390621.1" /db_xref="EnsemblGenomes-Gn:BSU27440" /db_xref="EnsemblGenomes-Tr:CAB14685" /db_xref="GOA:O34563" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11486" /db_xref="UniProtKB/Swiss-Prot:O34563" /translation="MKKIFSLALISLFAVILLAACGSKGSNGEASKESKKDTLAAIKD NDKIVFGVKTDTRLFGLKNPSSGEIEGFDIDIAKQIAKDILGDEKKAQFKEVTSKTRI PMLQNGDIDAIVATMTITEERKKEVDFSDVYFEAGQSLLVKKGSKIKSVENLGKGSKV LAVKGSTSSQNIREKAPEASVLEFENYAEAFTALKSGQGDALTTDNAILYGMADENKN YQLTGKPFTDEPYGIAVKKGQSALAKEINASLKKMKSDGRYDEIYKKWIKEDPAE*" /label="glnH CDS" gene 2239005..2239826 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /label="glnH gene" CDS 2239887..2240537 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390622.1" /db_xref="EnsemblGenomes-Gn:BSU27450" /db_xref="EnsemblGenomes-Tr:CAB14686" /db_xref="GOA:O34671" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11487" /db_xref="UniProtKB/Swiss-Prot:O34671" /translation="MNVSILFDNFSMYMDGFYHTLLASVIALAGSFVLGVAVAVMRIT VFKPLQWLGTAYVEFIRNIPLLLITFVFYFGLPNAGLRLDGFQAGTVALTIYTSAFIA EAIRAGIQSVSKGQMEAARSSGFTYSQAMLHIILPQAIKIVIPPLGNQFLNLVKNSSI LGVVAGLDLMYQADLVSSSTLVVFDVYIFVALFYLVLTIPLSIGVNYLEKRLEKSY*" /label="glnM CDS" gene 2239887..2240537 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /label="glnM gene" CDS 2240554..2241210 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390623.1" /db_xref="EnsemblGenomes-Gn:BSU27460" /db_xref="EnsemblGenomes-Tr:CAB14687" /db_xref="GOA:O34606" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11488" /db_xref="UniProtKB/Swiss-Prot:O34606" /translation="MDFIGAYSQEHLAFLWDGFLVTLYVAFISIILSFFFGLIAGTLR YAKVPVLSQLIAVLVETIRNLPLLLIIFFTFFALPEIGIKLEITAAAITALTIFESAM LSEIIRSGLKSIDKGQIEAARSSGLSYTQTLFFIVMPQALRRMVPPIVSQFISLLKDT SLAVVIALPELIHNAQIINGQSADGSYFFPIFLLAALMYFAVNYSLSLAARRLEVRQT *" /label="glnP CDS" gene 2240554..2241210 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /label="glnP gene" downshifts 2241209 /Source="Nicolas_upshifts" /id="D1403" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.21558" /MaxDrop="6.08472" /score="5.38937989" /energy="-11.7" /TU="NA" /idTUdmin="U2116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2241245..2241376) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097766.1" /db_xref="EnsemblGenomes-Gn:BSU27468" /db_xref="EnsemblGenomes-Tr:CAX52672" /db_xref="InterPro:IPR025029" /db_xref="UniProtKB/Swiss-Prot:C0H461" /translation="MNRTMTSLLAMGAGALVYRMATQSDMLNNRSMKRMRRRITKMF* " /label="yrzQ CDS" gene complement(2241245..2241376) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /label="yrzQ gene" downshifts complement(2241263) /Source="Nicolas_upshifts" /id="D1404" /incds=0 /nref=50 /ntot=77 /MaxReadThrough="1.58565" /MaxDrop="8.21989" /score="5.69801689" /energy="-11.7" /TU="NA" /idTUdmin="U2118" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2241398..2241589) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097767.1" /db_xref="EnsemblGenomes-Gn:BSU27469" /db_xref="EnsemblGenomes-Tr:CAX52673" /db_xref="UniProtKB/Swiss-Prot:C0H462" /translation="MLICPNCKSKDIGKIGVNQYYCWGCFIELTVAKGKIATHQVEED GTLSSLDDLFSEDERSINF*" /label="yrzR CDS" gene complement(2241398..2241589) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /label="yrzR gene" CDS complement(2241601..2242125) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390624.1" /db_xref="EnsemblGenomes-Gn:BSU27470" /db_xref="EnsemblGenomes-Tr:CAB14688" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13790" /db_xref="UniProtKB/Swiss-Prot:O34402" /translation="MSLRRKAKPKPVQQKVVDHTLRTCHEVEGFPVYSERTSSYLGTI SDICFSLKGDCLGFILAQKRFLHHHHALLRACDISSIFDDRILASVSSEQLLPLPKSC FTYEQMKMKLVKSQEGDILGMLEDVYFCLDRGIIVAYELSDGFFSDLAGSKRQIQRAD SLVEVRKDEIVLNG*" /label="yrrD CDS" gene complement(2241601..2242125) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /label="yrrD gene" upshifts complement(2241712) /Source="Nicolas_upshifts" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2241716..2241727) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2241742..2241748) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2242096..2242107) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2242102) /Source="Nicolas_upshifts" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2242122..2242128) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2242183..2244579) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /EC_number="3.1.11.5" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3537961, 11557815, 21170359, 22720735, 24443534, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3537961, 11557815, 21170359, 22720735, 24443534, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5'-3' helicase associated to SSB; exonuclease V" /protein_id="NP_390625.1" /db_xref="EnsemblGenomes-Gn:BSU27480" /db_xref="EnsemblGenomes-Tr:CAB14689" /db_xref="GOA:O34481" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR006345" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="InterPro:IPR029493" /db_xref="SubtiList:BG13789" /db_xref="UniProtKB/Swiss-Prot:O34481" /translation="MQQHPDQLKLEEEPYLKGTVNTVIYHNDTNLYTVLKVKVTETSE AIEDKAVSVTGYFPALQEEETYTFYGKIVTHPKFGLQFQAEHFKKEIPTTKEGIIQYL SSDLFEGIGKKTAEEIVKKLGDSAINKILADASVLYDVPRLSKKKADTLAGALQRHQG LEQIMISLNQFGFGPQLSMKIYQAYESETLEKIQENPYQLVKDVEGIGFGKADELGSR MGLSGNHPERVKAAILYTLETTCLSEGHTYIETEQLIIDTQSLLNQSAREGQRITEMD AANAIIALGENKDIVIEDGRCYFPSLFYAEQNVAKRVKHIASQTEYENQFPESEFLLA LGELEERMDVQYAPSQKEAIQKALSSPMLLLTGGPGTGKTTVIRGIVELYGELHGVSL DPSAYKKDEAFPIVLAAPTGRAAKRMSESTGLPAVTIHRLLGWNGAEGFTHTEDQPIE GKLLIIDEASMLDIWLANHLFKAIPDHIQIIIVGDEDQLPSVGPGQVLRDLLASQVIP TVRLTDIYRQAEGSSIVELAHQMKNGLLPNNLTAPTKDRSFIRCGGSQIKEVVEKVVA NALKKGYTAKDIQVLAPMYRGKAGINELNVMLQDILNPPKEKRRELKFGDVVYRTGDK ILQLVNQPENNVFNGDIGEITSIFYAKENTEKEDMAVVSFDGNEMTFTKKDFNQFTHA YCCSIHKSQGSEFPIVVLPVVKGYYRMLRRNLLYTAITRAKKFLILCGEEEALEWGVK NNDATVRQTSLKNRLSVQVEEMDAELEALQKELPFSVHDANIGMEGITPFDFMKEEQQ *" /label="recDB CDS" gene complement(2242183..2244579) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /label="recDB gene" downshifts complement(2242209) /Source="Nicolas_upshifts" /id="D1405" /incds=0 /nref=32 /ntot=211 /MaxReadThrough="2.07603" /MaxDrop="3.57113" /score="41.0323102" /energy="-10.8" /TU="NA" /idTUdmin="U2121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2242429..2242435 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2242443 /Source="Nicolas_upshifts" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2242450..2242461 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2242463..2242812 /Source="Nicolas_S_feature" /locus_tag="new_2806566_2806915" /HighExp="S8, S5, S6, S7, S4, C30, nit, ferm, G135, T5.0H" /AntisenseName="yrrC" /AntisenseCor="-0.46935785055870999" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1042" downshifts complement(2242564) /Source="Nicolas_upshifts" /id="D1406" /incds=1 /nref=16 /ntot=163 /MaxReadThrough="4.93428" /MaxDrop="2.86437" /score="41.0323102" /energy="-10.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-355" /isTUend="FALSE" /label="downshifts" CDS complement(2244604..2245224) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11777911, 12594026, 18180259; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative tetratricopeptide repeat family protein" /protein_id="NP_390626.1" /db_xref="EnsemblGenomes-Gn:BSU27490" /db_xref="EnsemblGenomes-Tr:CAB14690" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR013105" /db_xref="InterPro:IPR019734" /db_xref="PDB:2Q7F" /db_xref="SubtiList:BG13788" /db_xref="UniProtKB/Swiss-Prot:O34452" /translation="MQEGDYEKAAEAFTKAIEENKEDAIPYINFANLLSSVNELERAL AFYDKALELDSSAATAYYGAGNVYVVKEMYKEAKDMFEKALRAGMENGDLFYMLGTVL VKLEQPKLALPYLQRAVELNENDTEARFQFGMCLANEGMLDEALSQFAAVTEQDPGHA DAFYNAGVTYAYKENREKALEMLDKAIDIQPDHMLALHAKKLIDPS*" /label="yrrB CDS" gene complement(2244604..2245224) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /label="yrrB gene" CDS complement(2245310..2246425) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /EC_number="2.8.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-specific 2-thiouridylase" /protein_id="NP_390627.3" /db_xref="EnsemblGenomes-Gn:BSU27500" /db_xref="EnsemblGenomes-Tr:CAB14691" /db_xref="GOA:O35020" /db_xref="InterPro:IPR004506" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023382" /db_xref="SubtiList:BG13787" /db_xref="UniProtKB/Swiss-Prot:O35020" /translation="MEKRPEDTRVVVGMSGGVDSSVAALLLKEQGYDVIGIFMKNWDD TDENGFCTATEDYEDVIRVCNQIGIPYYAVNFEKQYYEKVFQYFLDEYKAGRTPNPDV LCNKEIKFKAFLEHALSLGADYLATGHYARVDRSGGKVRMLRGIDENKDQTYFLNQLT EDTLSKVMFPIGELQKSRVREIAKEAELATATKKDSTGICFIGERNFKTFLSQYLPAQ PGDMMTMDGEVKGRHDGLMYYTIGQRHGLGIGGSGEPWFAVGKDLEKNILYVDQGFHN PLLYSDKITATNISWVRSDIMKGEEISCTAKFRYRQEDHKVTVRMTGEGEAEVIFDEQ VRAVTPGQAVVFYDGEECLGGGTIDDVYKDGTKLWYV*" /label="mnmA CDS" gene complement(2245310..2246425) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /label="mnmA gene" downshifts complement(2245311) /Source="Nicolas_upshifts" /id="D1407" /incds=0 /nref=2 /ntot=69 /MaxReadThrough="6.45399" /MaxDrop="4.31641" /score="2.49091848" /energy="-7.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" CDS complement(2246456..2247595) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496536, 10930739, 12682299, 17064282, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496536, 10930739, 12682299, 17064282, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase involved in U34 tRNA thiolation" /protein_id="NP_390629.2" /db_xref="EnsemblGenomes-Gn:BSU27510" /db_xref="EnsemblGenomes-Tr:CAB14693" /db_xref="GOA:O34599" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG13809" /db_xref="UniProtKB/Swiss-Prot:O34599" /translation="MERIYLDHAATSPMDERVLEQMIPHFSGSFGNPSSIHSFGRESR KWVDEARAQIAAEIGAAEQEIIFTSGGTEADNLAIMGTALARKDLGRHIITTKIEHHA VLHTCEKLEGDGFDITYLDVDQNGRVSAKQVKEALRDDTILVTVMYGNNEVGTVQPIE EIGELLKEHKAYFHTDAVQAFGLLPIDVKNSHIDLLSVSGHKLNGPKGTGFLYASKDV KLSPLLFGGEQERKRRAGTENVPGIVGLKEAIKLSSEERDEKNEKYQSFKAIFADTLR DAGVAFEVNGDKEHSLPHVLNLYFPGVSVEALLVNLDMAGVAVSSGSACTAGSVLPSH VLTAMFGEESDRLTSSIRISFGLGNTAEQVKTAAKHVADVVKRLT*" /label="iscSA CDS" gene complement(2246456..2247595) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /label="iscSA gene" promotor_-10 complement(2247162..2247181) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2247174) /Source="Nicolas_upshifts" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2247195..2247202) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2247614..2248030) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of cysteine biosynthesis" /protein_id="NP_390630.2" /db_xref="EnsemblGenomes-Gn:BSU27520" /db_xref="EnsemblGenomes-Tr:CAB14694" /db_xref="GOA:O34527" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2Y75" /db_xref="SubtiList:BG13813" /db_xref="UniProtKB/Swiss-Prot:O34527" /translation="MKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQ LVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISPVEVLEDEEPAKRE LWIRIRDAVKEVLDSTTLEDLASYTDGEQEAYMFYI*" /label="cymR CDS" gene complement(2247614..2248030) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /label="cymR gene" S_feature complement(2248031..2248128) /Source="Nicolas_S_feature" /locus_tag="new_2812134_2812231_c" /HighExp="Cold, T3.0H, G135, LBGexp, G180, G150, Salt, Lbexp, H2O2, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1043" promotor_-10 complement(2248113..2248132) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2248128) /Source="Nicolas_upshifts" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2248148..2248151) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2248176..2248183 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2248197..2248216 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2248205 /Source="Nicolas_upshifts" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="upshifts" CDS 2248233..2249498 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15743409, 17641684, 21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743409, 17641684, 21170359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-dependent ATPase active at replication forks" /protein_id="NP_390631.1" /db_xref="EnsemblGenomes-Gn:BSU27530" /db_xref="EnsemblGenomes-Tr:CAB14695" /db_xref="GOA:O34528" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR021886" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032423" /db_xref="SubtiList:BG13808" /db_xref="UniProtKB/Swiss-Prot:O34528" /translation="MKPLAYRMRPTKIEDIIGQQHLVAEDKIIGRMVQAKHLSSMILY GPPGIGKTSIATAIAGSTSIAFRKLNAVINNKKDMEIVAQEAKMSGQVILILDEVHRL DKGKQDFLLPYLENGMIILIGATTANPYHAINPAIRSRTQIFELEPLTPELIKQALER ALHDEHRGLGTYSVSIDDQAMEHFAHGCGGDVRSALNALELAVLSTKESADGEIHITL ETAEECLQKKSFSHDKDGDAHYDVLSAFQKSIRGSDANAALHYLARLIEAGDLESIAR RLLVIAYEDIGLASPQAGPRVLNAIQTAERVGFPEARIPLANAVIELCLSPKSNSAIL AIDEALADIRAGKIGDVPKHLKDAHYKGAQELGRGIDYKYPHNYDNGWVEQQYLPDPL KNKQYYKPKQTGKFESALKQVYDKLMKRK*" /label="rarA CDS" gene 2248233..2249498 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /label="rarA gene" downshifts 2249497 /Source="Nicolas_upshifts" /id="D1408" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="1.09429" /MaxDrop="4.5261" /score="14.6665846" /energy="-12" /TU="NA" /idTUdmin="U2123" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2249540..2250304) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /EC_number="6.1.-.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12177353, 20097860, 23242255, 27913733, 28671653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA threonylcarbamoyladenosine dehydratase (t(6)A37 dehydratase)" /protein_id="NP_390632.3" /db_xref="EnsemblGenomes-Gn:BSU27540" /db_xref="EnsemblGenomes-Tr:CAB14713" /db_xref="GOA:O32037" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13807" /db_xref="UniProtKB/Swiss-Prot:O32037" /translation="MLHQFSRNELAIGKEGLETLKNSTVAVLGVGGVGSFAAEALARS GVGRILLVDKDDVDITNVNRQLHALLSTVGQPKVDLMKARIADINPECEVIALKMFYT EETYEQFFDYGLDYVIDASDTICYKIHLMKECLKRDIPLISSMGAANKTDPTRFQIAD ISKTHTDPIAKVVRTKLRKEGIKKGVQVIFSDESPIVIREDVRKEVGNDEAKIRKAKM PPSSNAFVPSVAGLIMGGHVVMDLLKDIEIKRVKDK*" /label="tcdA CDS" gene complement(2249540..2250304) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /label="tcdA gene" downshifts complement(2249558) /Source="Nicolas_upshifts" /id="D1409" /incds=0 /nref=246 /ntot=264 /MaxReadThrough="2.35294" /MaxDrop="7.20309" /score="44.7253801" /energy="-12" /TU="NA" /idTUdmin="U2125" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2250388..2250588) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /product="6Sb RNA" /experiment="publication(s) with functional evidences, PMID:12177353, 15793584, 15811922, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 15793584, 15811922, 25576829, 26873600; Product type n: RNA" /label="ssrSB RNA" gene complement(2250388..2250588) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /label="ssrSB gene" downshifts complement(2250406) /Source="Nicolas_upshifts" /id="D1410" /incds=0 /nref=81 /ntot=303 /MaxReadThrough="7.44881" /MaxDrop="6.73892" /score="44.7253801" /energy="-12" /TU="U2125,U2127" /idTUdmin="U2125" /TUdmin="-848" /isTUend="FALSE" /label="downshifts" upshifts 2250575 /Source="Nicolas_upshifts" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2250576..2250585 /Source="Nicolas_upshift_promotors" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2250586..2250605) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2250597) /Source="Nicolas_upshifts" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2250618..2250625) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2250640..2252418) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /EC_number="6.1.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12177353, 26804570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartyl-tRNA synthetase, promiscuous (also recognizes tRNAasn)" /protein_id="NP_390633.1" /db_xref="EnsemblGenomes-Gn:BSU27550" /db_xref="EnsemblGenomes-Tr:CAB14714" /db_xref="GOA:O32038" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004115" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004524" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029351" /db_xref="SubtiList:BG12572" /db_xref="UniProtKB/Swiss-Prot:O32038" /translation="MFGRTYYCGDITEKAIGESVTLKGWVQKRRDLGGLIFIDLRDRT GIVQVVFNPDVSKEALAIAEGIRNEYVLDIQGKVVAREEGTVNPNLKTGAIEIHADGV NVLNAAKTPPFAISDQAEEVSEDVRLKHRYLDLRRPAMFQTMQLRHNVTKAVRSFLDE NGFLDIETPILTGSTPEGARDYLVPSRVHEGEFYALPQSPQLFKQLLMVSGIERYYQI ARCFRDEDLRADRQPEFTQIDIEMSFMSQEDIMSLAEEMMAKVMRETKGEELQLPLPR MTYDEAMNKYGSDKPDTRFDMLLTDVSDIVKDTEFKVFSSAVANGGVVKAINVKGGAG DYSRKDIDALGAFAANYGAKGLAWVKVEADGVKGPIAKFFDEEKQSKLIEALDAAEGD LLLFGADQFEVVAASLGALRLKLGKERGLIDEKLFNFLWVIDWPLLEHDPEEGRFYAA HHPFTMPVREDLELIETAPEDMKAQAYDLVLNGYELGGGSIRIFEKDIQEKMFALLGF SPEEAAEQFGFLLEAFEYGAPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCL MTEAPGEVSDAQLDELHLSIKKKVKN*" /label="aspS CDS" gene complement(2250640..2252418) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /label="aspS gene" CDS complement(2252432..2253706) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /EC_number="6.1.1.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28321488; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase" /protein_id="NP_390634.1" /db_xref="EnsemblGenomes-Gn:BSU27560" /db_xref="EnsemblGenomes-Tr:CAB14715" /db_xref="GOA:O32039" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR015807" /db_xref="InterPro:IPR033656" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG12605" /db_xref="UniProtKB/Swiss-Prot:O32039" /translation="MGYNIPRGTQDILPGESDRWQFVEQIMRDTCRTYQYKEIRTPIF EHTELFARGVGESTDIVQKEMYTFEDRKGRSLTLRPEGTAAAVRAFNENKLFANPVQP TKLYYVGPMFRYERPQTGRYRQFYQFGIEAIGSKDPAIDAEVMALAMSIYEKAGLENV KLVINSLGDQDSRKSYREALVKHFEPRIEEFCSDCQSRLHTNPLRILDCKKDRDHELM KSAPSILTYLNEESAAYFEKVKQYLNDLGISYEIDPNLVRGLDYYNHTAFEIMSNAEG FGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAEKRELPVDKGIDCYI VTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLKARFIAILGEDELA QNKINVKDAQTGEQIEVALDEFIHVMKANQKG*" /label="hisS CDS" gene complement(2252432..2253706) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /label="hisS gene" misc_RNA complement(2253796..2254028) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /product="T-box riboswitch controlling synthesis of histidine and aspartate tRNA ligases" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.3: Control" /label="tboH RNA" gene complement(2253796..2254028) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /label="tboH gene" downshifts complement(2253826) /Source="Nicolas_upshifts" /id="D1411" /incds=0 /nref=71 /ntot=180 /MaxReadThrough="7.0761" /MaxDrop="5.61082" /score="40.6097692" /energy="-23.7" /TU="U2127" /idTUdmin="U2128" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2254038..2254041 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2254052..2254071) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2254056..2254075 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2254058..2254342 /Source="Nicolas_S_feature" /locus_tag="new_2818161_2818445" /HighExp="H2O2, G135, G180, C30, G150, Paraq, Oxctl, dia15, LBGstat, LBGexp" /AntisenseName="yrzK" /AntisenseCor="-0.27832941694878799" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1044" upshifts 2254058 /Source="Nicolas_upshifts" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2254071) /Source="Nicolas_upshifts" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2254086..2254093) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2254088..2254258) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390635.1" /db_xref="EnsemblGenomes-Gn:BSU27570" /db_xref="EnsemblGenomes-Tr:CAB14716" /db_xref="InterPro:IPR035378" /db_xref="SubtiList:BG13820" /db_xref="UniProtKB/Swiss-Prot:O32040" /translation="MKYHPKMGRAFHDGEANLHYSDHADPDTTGYLTETASEFGLMSK EAALRKNNRNKA*" /label="yrzK CDS" gene complement(2254088..2254258) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /label="yrzK gene" promotor_-10 complement(2254289..2254300) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-10" upshifts complement(2254306) /Source="Nicolas_upshifts" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="upshifts" promotor_-35 complement(2254315..2254321) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-35" promotor_-35 2254318..2254325 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2254339..2254357 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2254344 /Source="Nicolas_upshifts" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2254391..2255947 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /EC_number="3.5.1.28" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetylmuramoyl-L-alanine amidase, family 3" /protein_id="NP_390636.1" /db_xref="EnsemblGenomes-Gn:BSU27580" /db_xref="EnsemblGenomes-Tr:CAB14717" /db_xref="GOA:O32041" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR017293" /db_xref="SubtiList:BG13806" /db_xref="UniProtKB/Swiss-Prot:O32041" /translation="MNKKYFVLIVCIIFTSALFPTFSSVTAAQGEAVIATDEMNVRSG PGLSYGITAEVKKGERYPILKEDGDWVQIQLGSGEKGWVVSWLITKEDQASTSSSGSS DTVTSTDPDLRMRSGPGTSYEVIGKFPQGSQASVIDKDSGWIKISYHSATGWVSSEYV TSGGSSSASDESDQTEDSGASTTGTVGVSSLNVRASASHDAAIITKLDRGTKLTVLNE KNGWAHIEVNGLKGWVASHYLLTSSVPADDSANAGSSSSAKKAYIMYGGTNLRSDAST SASIVERAAKGDSYTITGSKGSWYEIKLDNGQTAYVANWVVQTSKSAEEAGEPPVSDS PSGNGSLNNKTIIVDPGHGGKDSGTIGYSGKFEKNLTIKTAKLLASKLRSAGADVYVT RQDDTFVSLQSRVSTSHYRNADAFISIHYDSYADTSTRGSTAYYYSPAKDQELASDVH SEVVKRSSIPDRGVLFGDYYVLRENRQPAMLYELGYVSHPQEEAIVHSNSYQEKVTDG IESGLEKYFQ*" /label="yrvJ CDS" gene 2254391..2255947 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /label="yrvJ gene" downshifts 2255926 /Source="Nicolas_upshifts" /id="D1412" /incds=0 /nref=199 /ntot=249 /MaxReadThrough="2.10072" /MaxDrop="7.40599" /score="44.9570925" /energy="-9.9" /TU="U2126" /idTUdmin="U2129" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2255974..2256372) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15292242, 15525705, 16844682, 18700836, 28362257; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gly-tRNA(Ala) deacylase / D-Tyr-tRNATyr deacylase" /protein_id="NP_390637.2" /db_xref="EnsemblGenomes-Gn:BSU27590" /db_xref="EnsemblGenomes-Tr:CAB14718" /db_xref="GOA:O32042" /db_xref="InterPro:IPR003732" /db_xref="InterPro:IPR023509" /db_xref="SubtiList:BG13805" /db_xref="UniProtKB/Swiss-Prot:O32042" /translation="MDEEVVGQIGQGLMVLVGITHDDTEDDAAYLADKVVNLRIFDDS EGKMNLSLVDIGGEILSVSQFTLYGDTKKGRRPNYMNAAKPDKALGLYEKWNDLLREK GIKVETGTFGAMMDVQLTNSGPVTLIMDSK*" /label="dtd CDS" gene complement(2255974..2256372) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /label="dtd gene" downshifts complement(2255982) /Source="Nicolas_upshifts" /id="D1413" /incds=0 /nref=152 /ntot=267 /MaxReadThrough="2.01735" /MaxDrop="9.47739" /score="37.3693259" /energy="-9.9" /TU="NA" /idTUdmin="U2130" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2256426..2258630) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /EC_number="2.7.6.5" /EC_number="3.1.7.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTP pyrophosphokinase (RelA/SpoT)" /protein_id="NP_390638.2" /db_xref="EnsemblGenomes-Gn:BSU27600" /db_xref="EnsemblGenomes-Tr:CAB14719" /db_xref="GOA:O54408" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004811" /db_xref="InterPro:IPR007685" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR033655" /db_xref="SubtiList:BG12665" /db_xref="UniProtKB/Swiss-Prot:O54408" /translation="MANEQVLTAEQVIDKARSYLSDEHIAFVEKAYLYAEDAHREQYR KSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVVEDTDVTLDDLKEAFSEEVAMLV DGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYV DEVVNEVKKRVEEVNIKADFSGRPKHIYSIYRKMVLQNKQFNEIYDLLAVRILVNSIK DCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHE IAEYGVAAHWAYKEGKAANEGATFEKKLSWFREILEFQNESTDAEEFMESLKIDLFSD MVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVE ILTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENVEKGRELVEKEIKNLDFEL KDVLTPENIQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKQRDQEEQEKI VQEVTGEPKPYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDDIVGFITKGRGVSVH REDCPNVKTNEAQERLIPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVLQAVNET KTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRRVMN*" /label="rsh CDS" gene complement(2256426..2258630) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /label="rsh gene" promotor_-10 complement(2258659..2258678) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2258666) /Source="Nicolas_upshifts" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2258668..2258758) /Source="Nicolas_S_feature" /locus_tag="new_2822771_2822861_c" /HighExp="Cold, G135, G180, G150, H2O2, Paraq, Oxctl, C30, LBGexp, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="0.951, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 1" /label="S1045" promotor_-35 complement(2258693..2258700) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2258722 /Source="Nicolas_upshifts" /id="D1414" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.75679" /MaxDrop="3.54336" /score="0.486890657" /energy="-12.7" /TU="NA" /idTUdmin="U2126" /TUdmin=2772 /isTUend="FALSE" /label="downshifts" CDS complement(2258798..2259310) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /EC_number="2.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 9383190, 15629952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 9383190, 15629952; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine phosphoribosyltransferase" /protein_id="NP_390639.1" /db_xref="EnsemblGenomes-Gn:BSU27610" /db_xref="EnsemblGenomes-Tr:CAB14720" /db_xref="GOA:O34443" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005764" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG12568" /db_xref="UniProtKB/Swiss-Prot:O34443" /translation="MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYA KEKQIDLVVGPEARGFIIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLT IHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLE DYDILTLMKY*" /label="apt CDS" gene complement(2258798..2259310) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /label="apt gene" downshifts complement(2258803) /Source="Nicolas_upshifts" /id="D1415" /incds=0 /nref=39 /ntot=228 /MaxReadThrough="5.36411" /MaxDrop="4.05036" /score="2.83935873" /energy="-6.8" /TU="U2131,U2132,U2133" /idTUdmin="U2131" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" CDS complement(2259316..2261676) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21087930, 21170359, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21087930, 21170359, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="single-strand DNA-specific exonuclease" /protein_id="NP_390640.1" /db_xref="EnsemblGenomes-Gn:BSU27620" /db_xref="EnsemblGenomes-Tr:CAB14721" /db_xref="GOA:O32044" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR004610" /db_xref="InterPro:IPR018779" /db_xref="SubtiList:BG13804" /db_xref="UniProtKB/Swiss-Prot:O32044" /translation="MLASKMRWEIQRPDQDKVKSLTEQLHITPLVASLLVKRGFDTAE SARLFLHTKDADFYDPFEMKGMKEAADRIKQAISQQEKIMIYGDYDADGVTSTSVMLH TLQKLSAQVDFYIPDRFKEGYGPNEQAFRSIKERGFSLIITVDTGIAAVHEAKVAKEL GLDVIITDHHEPGPELPDVRAIVHPKQPGCTYPFKELAGVGVAFKLAHALLGELPDEL LDLAAIGTIADLVPLHDENRLIATLGLERLRRTNRLGLKELIKLSGGDIGEANEETVG FQLAPRLNAVGRIEQADPAVHLLMSEDSFEAEELAAEIDQLNKERQKMVSKMTDEAIE MVEQQGLDQTAIVVAKAGWNPGVVGIVASKLVDRFYRPAIVLGIDEEKGIAKGSARSI RGFNLFESLSECRDILPHFGGHPMAAGMTLKAEDVPDLRSRLNEIADNTLTEEDFIPV QEVDLVCGVEDITVESIAEMNMLSPFGMLNPKPHVLVENAVLEDVRKIGANKTHVKMT IRNESSQLDCVGFNKGELQEGIVPGSRISIVGEMSINEWNNRKKPQLMIKDAAVSEWQ LFDLRGKRTWEDTVSALPSAKRAIVSFKEDSTTLLQTEDLRREVHVISSKDQAKAFDL DGAYIVLLDPPPSLDMLARLLEGKAPERIYFIFLNHEDHFLSTFPARDHFKWYYAFLL KRGAFDVKKHGSELAKHKGWSVETINFMTKVFFDLGFVKIENGVLSVVSGAKKRDLTD SQTYQAKQQLMELDQKLNYSSAEELKEWLNKLMKQDSEAYESTRRT*" /label="recJ CDS" gene complement(2259316..2261676) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /label="recJ gene" promotor_-10 complement(2259780..2259799) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2259788) /Source="Nicolas_upshifts" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2259813..2259822) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-35" promotor_-10 complement(2261690..2261709) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2261701) /Source="Nicolas_upshifts" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2261724..2261730) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2261743..2262066) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390641.1" /db_xref="EnsemblGenomes-Gn:BSU27630" /db_xref="EnsemblGenomes-Tr:CAB14722" /db_xref="GOA:O32045" /db_xref="InterPro:IPR010445" /db_xref="SubtiList:BG13803" /db_xref="UniProtKB/Swiss-Prot:O32045" /translation="MNKQWTIIFALIFTLIVAIFAVINVRSVEVDYLFGRSEWPLILV ILGSVLMGALIVFSVGIFQVMKLKREIKTLRKENRTAIHKQEDTHLADQTDTQDASAM IEKKD*" /label="yrvD CDS" gene complement(2261743..2262066) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /label="yrvD gene" promotor_-10 complement(2262087..2262105) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2262098) /Source="Nicolas_upshifts" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2262120..2262126) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-35" CDS complement(2262142..2262639) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative potassium transport accessory component" /protein_id="NP_390642.1" /db_xref="EnsemblGenomes-Gn:BSU27640" /db_xref="EnsemblGenomes-Tr:CAB14723" /db_xref="GOA:O32046" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13802" /db_xref="UniProtKB/Swiss-Prot:O32046" /translation="MRVRESELPGIGQKVEMITRNRDKISIIIHHDGRRELYYFDEND HEECVASVQFDDAEARQMSAILGGMAYKPKALEQVESALDDLIIEWCKAEAGAPAIHQ TIGDLNVGQEYHVTVIAIVKKNQDKQLNPSSETVIDEGDTLVISGEGTGLKRLIREKL TAKGA*" /label="yrvC CDS" gene complement(2262142..2262639) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /label="yrvC gene" S_feature complement(2262640..2262715) /Source="Nicolas_S_feature" /locus_tag="new_2826743_2826818_c" /HighExp="Oxctl, HiOs, G180, LBGexp, Paraq, G150, G135, H2O2, MG-0.2, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1046" promotor_-10 complement(2262709..2262728) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-10" upshifts complement(2262715) /Source="Nicolas_upshifts" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="upshifts" promotor_-35 complement(2262742..2262749) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-35" CDS complement(2262797..2265010) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9694879, 15941986, 15995216, 16517687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9694879, 15941986, 15995216, 16517687; Product type t: transporter" /codon_start=1 /transl_table=11 /product="protein-export membrane protein" /protein_id="NP_390643.1" /db_xref="EnsemblGenomes-Gn:BSU27650" /db_xref="EnsemblGenomes-Tr:CAB14724" /db_xref="GOA:O32047" /db_xref="InterPro:IPR005665" /db_xref="InterPro:IPR005791" /db_xref="InterPro:IPR022645" /db_xref="InterPro:IPR022646" /db_xref="InterPro:IPR022813" /db_xref="SubtiList:BG12672" /db_xref="UniProtKB/Swiss-Prot:O32047" /translation="MKKGRLIAFFLFVLLIGTGLGYFTKPAANNITLGLDLQGGFEVL YDVQPVKKGDKITKDVLVSTVEALNRRANVLGVSEPNIQIEGNNRIRVQLAGVTNQNR AREILATEAQLSFRDANDKELLNGADLVENGAKQTYDSTTNEPIVTIKLKDADKFGEV TKKVMKMAPNNQLVIWLDYDKGDSFKKEVQKEHPKFVSAPNVSQELNTTDVKIEGHFT AQEAKDLASILNAGALPVKLTEKYSTSVGAQFGQQALHDTVFAGIVGIAIIFLFMLFY YRLPGLIAVITLSVYIYITLQIFDWMNAVLTLPGIAALILGVGMAVDANIITYERIKE ELKLGKSVRSAFRSGNRRSFATIFDANITTIIAAVVLFIFGTSSVKGFATMLILSILT SFITAVFLSRFLLALLVESRWLDRKKGWFGVNKKHIMDIQDTDENTEPHTPFQKWDFT SKRKYFFIFSSAVTVAGIIILLVFRLNLGIDFASGARIEVQSDHKLTTEQVEKDFESL GMDPDTVVLSGEKSNIGVARFVGVPDKETIAKVKTYFKDKYGSDPNVSTVSPTVGKEL ARNALYAVAIASIGIIIYVSIRFEYKMAIAAIASLLYDAFFIVTFFSITRLEVDVTFI AAILTIIGYSINDTIVTFDRVREHMKKRKPKTFADLNHIVNLSLQQTFTRSINTVLTV VIVVVTLLIFGASSITNFSIALLVGLLTGVYSSLYIAAQIWLAWKGRELKKDSAQ*" /label="secDF CDS" gene complement(2262797..2265010) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /label="secDF gene" downshifts complement(2262802) /Source="Nicolas_upshifts" /id="D1416" /incds=0 /nref=174 /ntot=249 /MaxReadThrough="4.49738" /MaxDrop="5.0013" /score="29.1843057" /energy="-17.8" /TU="U2137" /idTUdmin="U2137" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" promotor_-35 2264569..2264574 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2264588..2264607 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2264596 /Source="Nicolas_upshifts" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2265049..2265345) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19028902, 27059541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19028902, 27059541; Product type r: regulator" /codon_start=1 /transl_table=11 /product="post-transcriptional regulator" /protein_id="NP_390644.1" /db_xref="EnsemblGenomes-Gn:BSU27660" /db_xref="EnsemblGenomes-Tr:CAB14726" /db_xref="GOA:O32049" /db_xref="InterPro:IPR025716" /db_xref="SubtiList:BG13814" /db_xref="UniProtKB/Swiss-Prot:O32049" /translation="MEKHPADLYKDHVRPFLYSKLEEFKILGYDDVELESLWSYLTDK KWKKKTELSIYELASDILSVKIGEFMNYATVESFKTSNWLGSEEGQEALEELLR*" /label="comN CDS" gene complement(2265049..2265345) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /label="comN gene" downshifts 2265256 /Source="Nicolas_upshifts" /id="D1417" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.36122" /MaxDrop="2.33158" /score="-9.07145122" /energy="-8.4" /TU="NA" /idTUdmin="U2136" /TUdmin="-2508" /isTUend="FALSE" /label="downshifts" S_feature complement(2265346..2265424) /Source="Nicolas_S_feature" /locus_tag="new_2829449_2829527_c" /HighExp="LBGtran, Lbtran, C90, M40t45, HiOs, Lbexp, Cold, M0t45, UNK1, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigH" /TUlongPSig=1 /label="S1047" promotor_-35 2265386..2265391 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-35" promotor_-10 2265408..2265426 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-10" promotor_-10 complement(2265410..2265429) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-10" upshifts 2265410 /Source="Nicolas_upshifts" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="upshifts" upshifts complement(2265424) /Source="Nicolas_upshifts" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="upshifts" S_feature complement(2265426..2266344) /Source="Nicolas_S_feature" /locus_tag="new_2829529_2830447_c" /HighExp="S2, M9-stat, Lbstat, BC, T2.0H, T3.0H, T2.30H, T3.30H, Cold, M0t90" /AntisenseName="spoVB" /AntisenseCor="-8.5173616652496897E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1048" promotor_-35 complement(2265444..2265447) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-35" CDS 2265461..2267017 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1744050, 15292147, 15849754, 16850406, 17714441, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744050, 15292147, 15849754, 16850406, 17714441, 19648239; Product type t : transporter" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation); translocase with flippase function for peptidoglycan synthesis" /protein_id="NP_390645.1" /db_xref="EnsemblGenomes-Gn:BSU27670" /db_xref="EnsemblGenomes-Tr:CAB14727" /db_xref="GOA:Q00758" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR014249" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10778" /db_xref="UniProtKB/Swiss-Prot:Q00758" /translation="MAKQTFLKGTLILIAAGMVTRMLGFVNRVVIARFIGEEGVGLYM MAAPTFFLATTLTQFGLPVAISKLVAEASARGDHQKTKNILVMSLTITGVLSLIFTPL FLFFAPVMAETMLTDKRTLYPLLAITPVVPIIAISSVLRGYFQGKQNMNPLAMSQVLE QVVRISLVAVCTTIFLPYGIEYAAAGAMLSSVAGELASLLYLFVCFKYKKTIKIRKHF LQSIKNGKQTFTQLMSVSLPTTGSRFIGNLSWFFEPIVVAQSLAIAGVATVAATKQYG ELTGFAMTLLTLPSFITYSLSTALVPAISEGMEQKKLQVVEYRLEQAMRLCLLSGGIS VVILFVFADELMRVMYGSSGAAVFIKVMAPFFLLYYFQGPLQAVLQALNLAGAAMMNS LIGALVKTGLIFVLATRPSLGIMGAALAIVTGMVLVTLLHAATVSKVLPISIKIKEYA LSFAVIVICGFISSAIKQYISFGASEAVNLAGWIAASAAIYMILLLVFRLIKKDELRR IPIIGRLIIR*" /label="spoVB CDS" gene 2265461..2267017 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /label="spoVB gene" promotor_-10 complement(2266330..2266348) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-10" upshifts complement(2266344) /Source="Nicolas_upshifts" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="upshifts" promotor_-35 complement(2266360..2266368) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-35" S_feature 2267018..2267782 /Source="Nicolas_S_feature" /locus_tag="new_2831121_2831885" /HighExp="S3, BT, S4, LoTm, S7, S8, T5.0H, T4.0H, M9-stat, T3.30H" /AntisenseName="yrbG" /AntisenseCor="0.65629957843767395" /AntisenseRegPval="-33.799999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1049" CDS complement(2267021..2267677) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390646.1" /db_xref="EnsemblGenomes-Gn:BSU27680" /db_xref="EnsemblGenomes-Tr:CAB14728" /db_xref="GOA:O32050" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG13786" /db_xref="UniProtKB/Swiss-Prot:O32050" /translation="MEELLTIAFRTVVLYFVILVIFRFMGKREIGELSILDLVVFIMM AEIAVLAIENVDDHLFHTILPMLVLMIIQVTLAYFSLKNRKVRQLLDGKPTIIIKYGK IDEEAMKSQRYNFDDLMVQLRENSIDRVADVSFAILEPSGKLTIVKKENSGEHRQLEM PLIIDGFIQTENLSRISKDRKWLLESLQKHGYTNPSDISFCSFTDGEIYIDEKDGHRT *" /label="yrbG CDS" gene complement(2267021..2267677) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /label="yrbG gene" promotor_-10 complement(2267696..2267707) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2267708) /Source="Nicolas_upshifts" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2267721..2267727) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2267760..2267765 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2267781..2267799 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2267784 /Source="Nicolas_upshifts" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2267812..2268264 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390647.1" /db_xref="EnsemblGenomes-Gn:BSU27690" /db_xref="EnsemblGenomes-Tr:CAB14729" /db_xref="GOA:O32051" /db_xref="InterPro:IPR023804" /db_xref="SubtiList:BG13815" /db_xref="UniProtKB/Swiss-Prot:O32051" /translation="MSDGFEQKEQKPFNTGREETIMEETKQVGKGILYGLIAIFSAML LTSLAVSLLLTATSLEESSFNWLITAISFLSLFIGGFISGGKGKERGWMIGALTALSF SLIILLFQYLGFGKTFTAEQLIFHLGFLGVCMLGGIFGVNMRGNRSST*" /label="yrzE CDS" gene 2267812..2268264 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /label="yrzE gene" downshifts 2268248 /Source="Nicolas_upshifts" /id="D1418" /incds=0 /nref=39 /ntot=61 /MaxReadThrough="1.45569" /MaxDrop="7.7199" /score="41.7975947" /energy="-15" /TU="NA" /idTUdmin="U2140" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2268303) /Source="Nicolas_upshifts" /id="D1419" /incds=0 /nref=188 /ntot=281 /MaxReadThrough="2.20451" /MaxDrop="7.91954" /score="33.5938356" /energy="-15" /TU="NA" /idTUdmin="U2141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2268321..2268587) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10974125, 16166550, 21235483, 26790414; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the preprotein translocase" /protein_id="NP_390648.2" /db_xref="EnsemblGenomes-Gn:BSU27700" /db_xref="EnsemblGenomes-Tr:CAB14730" /db_xref="GOA:O32052" /db_xref="InterPro:IPR003849" /db_xref="SubtiList:BG13785" /db_xref="UniProtKB/Swiss-Prot:O32052" /translation="MTGTLGTLVPIILMFAVLYFLLIRPQQKQQKAVRQMQEELKKGD SVVTIGGLHGTVDSIDESKVVIKTGDNTRLTFDRRAIREVSAAE*" /label="yrbF CDS" gene complement(2268321..2268587) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /label="yrbF gene" CDS complement(2268624..2269769) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /EC_number="2.4.2.29" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12123838, 14660578, 16199558, 16206323; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-guanine transglycosylase" /protein_id="NP_390649.1" /db_xref="EnsemblGenomes-Gn:BSU27710" /db_xref="EnsemblGenomes-Tr:CAB14731" /db_xref="GOA:O32053" /db_xref="InterPro:IPR002616" /db_xref="InterPro:IPR004803" /db_xref="InterPro:IPR036511" /db_xref="SubtiList:BG12686" /db_xref="UniProtKB/Swiss-Prot:O32053" /translation="MAEQPIRYEFIKECKQTGARLGKVHTPHGSFETPVFMPVGTLAT VKTMSPEELKAMDAGIILSNTYHLWLRPGQDIVKEAGGLHKFMNWDRAILTDSGGFQV FSLSKFRNIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPYPAEYD YMKRSVERTSRWAERCLNAHNRQDEQGLFGIVQGGEYEDLRTQSAKDLISLDFPGYAI GGLSVGEPKDVMNRVLEFTTPLLPKDKPRYLMGVGSPDALIDGAIRGVDMFDCVLPTR IARNGTVFTAEGRLNMKNAKFERDFRPIDEECDCYTCKNYTRAYIRHLIRCNETFGLR LTTYHNLHFLLHLMEQVRQAIREDRLGDFREEFFERYGYNKPNAKSF*" /label="tgt CDS" gene complement(2268624..2269769) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /label="tgt gene" upshifts complement(2268676) /Source="Nicolas_upshifts" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2268720) /Source="Nicolas_upshifts" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2268722..2268741) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2268756..2268761) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2269796..2270824) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /EC_number="2.4.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15822125, 17083917, 10739928" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15822125, 17083917, 10739928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine tRNA ribosyltransferase-isomerase" /protein_id="NP_390650.1" /db_xref="EnsemblGenomes-Gn:BSU27720" /db_xref="EnsemblGenomes-Tr:CAB14732" /db_xref="GOA:O32054" /db_xref="InterPro:IPR003699" /db_xref="InterPro:IPR036100" /db_xref="PDB:1YY3" /db_xref="SubtiList:BG12662" /db_xref="UniProtKB/Swiss-Prot:O32054" /translation="MKVDLFDFELPERLIAQVPLEQRDASRLMVLDKHTGELTDSSFK HIISFFNEGDCLVLNNTRVLPARLFGTKEDTGAKVELLLLKQETGDKWETLAKPAKRV KKGTVVTFGDGRLKAICTEELEHGGRKMEFQYDGIFYEVLESLGEMPLPPYIKEQLDD KERYQTVYSKEIGSAAAPTAGLHFTEEILQQLKDKGVQIEFITLHVGLGTFRPVSADE VEEHNMHAEFYQMSEETAAALNKVRENGGRIISVGTTSTRTLETIAGEHDGQFKASSG WTSIFIYPGYEFKAIDGMITNFHLPKSSLIMLVSALAGRENILRAYNHAVEEEYRFFS FGDAMLII*" /label="queA CDS" gene complement(2269796..2270824) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /label="queA gene" CDS complement(2270854..2271054) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="YP_003097768.1" /db_xref="EnsemblGenomes-Gn:BSU27729" /db_xref="EnsemblGenomes-Tr:CAX52674" /db_xref="GOA:C0H463" /db_xref="InterPro:IPR021320" /db_xref="UniProtKB/Swiss-Prot:C0H463" /translation="MTEFPKIIMILGAVLLIIGAVLHFVGKMPGDIFVKKGNVTFFFP VVTCIIISVVLSILLNLFGRMK*" /label="yrzS CDS" gene complement(2270854..2271054) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /label="yrzS gene" CDS complement(2271047..2272051) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /EC_number="3.1.22.4" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14701911, 15317759, 16267290, 19422832, 21600217, 24770420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase, ATP-dependent component" /protein_id="YP_054590.1" /db_xref="EnsemblGenomes-Gn:BSU27730" /db_xref="EnsemblGenomes-Tr:CAB14733" /db_xref="GOA:O32055" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004605" /db_xref="InterPro:IPR008823" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12669" /db_xref="UniProtKB/Swiss-Prot:O32055" /translation="MDERLVSSEADNHESVIEQSLRPQNLAQYIGQHKVKENLRVFID AAKMRQETLDHVLLYGPPGLGKTTLASIVANEMGVELRTTSGPAIERPGDLAAILTAL EPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATT RVGLLTAPLRDRFGVMSRLEYYTQEELADIVTRTADVFEVEIDKPSALEIARRSRGTP RVANRLLRRVRDFAQVLGDSRITEDISQNALERLQVDRLGLDHIDHKLLMGMIEKFNG GPVGLDTISATIGEESHTIEDVYEPYLLQIGFIQRTPRGRIVTPAVYHHFQMEAPRYD *" /label="ruvB CDS" gene complement(2271047..2272051) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /label="ruvB gene" CDS complement(2272062..2272667) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /EC_number="3.1.22.4" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16267290, 24770420" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16267290, 24770420; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase" /protein_id="NP_390652.1" /db_xref="EnsemblGenomes-Gn:BSU27740" /db_xref="EnsemblGenomes-Tr:CAB14734" /db_xref="GOA:O05392" /db_xref="InterPro:IPR000085" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR011114" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013849" /db_xref="InterPro:IPR036267" /db_xref="SubtiList:BG11973" /db_xref="UniProtKB/Swiss-Prot:O05392" /translation="MIEFVKGTIDYVSPQYIVIENGGIGYQIFTPNPFIYKERSQETI FTYHHIREDAFSLYGFSTREEKALFTKLLNVTGIGPKGALAILGSGDPGAVIQAIENE DEAFLVKFPGVGKKTARQIILDLKGKLADVVPEMIENLFNHEERLEKQTAETALEEAL EALRVLGYAEKEIKKVLPHLKEEIGLTTDQYVKKALQKLLK*" /label="ruvA CDS" gene complement(2272062..2272667) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /label="ruvA gene" promotor_-10 complement(2272686..2272705) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2272702) /Source="Nicolas_upshifts" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2272704..2272805) /Source="Nicolas_S_feature" /locus_tag="new_2836807_2836908_c" /HighExp="Etha, Heat, S8, S7, S4, S3, S6, S5, Salt, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1050" promotor_-35 complement(2272716..2272722) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2272806..2273318) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10931291, 16049010" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10931291, 16049010; Product type f: factor" /codon_start=1 /transl_table=11 /product="bypass of forespore C, intercompartmental signaling factor" /protein_id="NP_390653.1" /db_xref="EnsemblGenomes-Gn:BSU27750" /db_xref="EnsemblGenomes-Tr:CAB14735" /db_xref="GOA:O05391" /db_xref="InterPro:IPR015050" /db_xref="InterPro:IPR015071" /db_xref="PDB:2BW2" /db_xref="SubtiList:BG11917" /db_xref="UniProtKB/Swiss-Prot:O05391" /translation="MKRFSTAYLLLGILCSAAVFLIGAPSRALGAEVEHYEPLQVHVQ LEKVYLDGDVSIEHKHEKVFSMDDFWAAYAGWTLVEQKKGYVLFRKQMDDISPLSKVN GYIGVSDNGVISTFHGRPEPASEPIQSFFQIDLERLESHMQKNLLKGIPFRTKAEFED VIEHMKTYSG*" /label="bofC CDS" gene complement(2272806..2273318) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /label="bofC gene" promotor_-10 complement(2273347..2273358) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-10" upshifts complement(2273362) /Source="Nicolas_upshifts" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="upshifts" CDS complement(2273366..2274673) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099855, 14638426, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative catecholate siderophose exporter" /protein_id="NP_390654.2" /db_xref="EnsemblGenomes-Gn:BSU27760" /db_xref="EnsemblGenomes-Tr:CAB14736" /db_xref="GOA:O05390" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11922" /db_xref="UniProtKB/Swiss-Prot:O05390" /translation="MNTVHAKGNVLNKIGIPSHMVWGYIGVVIFMVGDGLEQGWLSPF LVDHGLSMQQSASLFTMYGIAVTISAWLSGTFVQTWGPRKTMTVGLLAFILGSAAFIG WAIPHMYYPALLGSYALRGLGYPLFAYSFLVWVSYSTSQNILGKAVGWFWFMFTCGLN VLGPFYSSYAVPAFGEINTLWSALLFVAAGGILALFFNKDKFTPIQKQDQPKWKELSK AFTIMFENPKVGIGGVVKTINAIGQFGFAIFLPTYLARYGYSVSEWLQIWGTLFFVNI VFNIIFGAVGDKLGWRNTVMWFGGVGCGIFTLALYYTPQLIGHQYWVLMIIACCYGAA LAGYVPLSALLPTLAPDNKGAAMSVLNLGSGLCAFIAPGIVSLFIGPLGAGGVIWIFA ALYFFSAFLTRFLTISEQSTDVYTEERFVRENVQTNFDKTVKQ*" /label="csbX CDS" gene complement(2273366..2274673) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /label="csbX gene" promotor_-35 complement(2273373..2273379) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-35" downshifts complement(2274627) /Source="Nicolas_upshifts" /id="D1420" /incds=0 /nref=2 /ntot=80 /MaxReadThrough="7.18585" /MaxDrop="3.0235" /score="-6.29978124" /energy="-14.3" /TU="U2145,U2146" /idTUdmin="U2146" /TUdmin="-1793" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2274697..2274715) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-10" upshifts complement(2274712) /Source="Nicolas_upshifts" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="upshifts" promotor_-35 complement(2274730..2274736) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-35" CDS complement(2274744..2275769) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative inositol-related oxidoreductase" /protein_id="NP_390655.1" /db_xref="EnsemblGenomes-Gn:BSU27770" /db_xref="EnsemblGenomes-Tr:CAB14737" /db_xref="GOA:O05389" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR030827" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12280" /db_xref="UniProtKB/Swiss-Prot:O05389" /translation="MTKQIVTGIIGAGRIGKLHVQNISRIPHMKIKAISDIQASRIKS WADSHQIEYITSDYRDLLHDPDIDAIFICSPTAVHAQMIKEAAEAKKHIFCEKPVSFS LDETSEALAAVRKHGVTLQVGFNRRFDPHFKKIKTIVENGEIGTPHLLKITSRDPEPP NIDYVRTSGGLFMDMSIHDFDMARYIMGSEVTEVYAKGAALVNPSFAELGDIDTAVIT LTFENGAMAVIDNSRQAVYGYDQRVEVFGTKGSAAADNSRPTTVEVSTADFVMKDKPH FFFLERYKDSYEEEILRFAEAIGTNQETPCTGNDGLQAGRIARAAQQSLAFGMPVSIE HTEKIAF*" /label="yrbE CDS" gene complement(2274744..2275769) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /label="yrbE gene" promotor_-10 complement(2275806..2275825) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-10" upshifts complement(2275826) /Source="Nicolas_upshifts" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="upshifts" promotor_-35 complement(2275840..2275847) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-35" promotor_-35 2275895..2275902 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2275916..2275935 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2275924 /Source="Nicolas_upshifts" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2275956..2275961 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2275970 /Source="Nicolas_upshifts" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2275977..2275995 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2276007..2276654 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /EC_number="2.7.11.1" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative serine/threonine-protein kinase" /protein_id="NP_390656.2" /db_xref="EnsemblGenomes-Gn:BSU27785" /db_xref="EnsemblGenomes-Tr:CAB14738" /db_xref="GOA:O32057" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13816" /db_xref="UniProtKB/Swiss-Prot:O32057" /translation="MLTKAEALAHTVIYRKNSRFDKVKEKSEELTLIGKGRSAYVFAL TEGGRKMALKVFFPEYQATAVKEAAIYEKLAGSAFYPDIYETGDSFILMEYIKGETFY NCLKKGIAISDDMIQQVEEALSDARAAGLNPSDIHLRNLILTETGAVRVIDVARFEQT KTCTQWDDLKSAYHALYKKPIFPKKIPGFWLEIIAFLYKKDWFQKHFAQRKRKYS*" /label="yrzF CDS" gene 2276007..2276654 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /label="yrzF gene" S_feature complement(2276329..2276662) /Source="Nicolas_S_feature" /locus_tag="new_2840432_2840765_c" /HighExp="LPhT, S8, BI, S7, S6, C30, Sw, BC, Gly, C90" /AntisenseName="yrzF" /AntisenseCor="0.348831504804749" /AntisenseRegPval="-8.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1051" downshifts 2276633 /Source="Nicolas_upshifts" /id="D1421" /incds=0 /nref=29 /ntot=228 /MaxReadThrough="2.4121" /MaxDrop="5.05737" /score="20.8102477" /energy="-18.2" /TU="NA" /idTUdmin="U2147" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(2276664..2276861) /Source="Nicolas_S_feature" /locus_tag="new_2840767_2840964_c" /HighExp="LPhT, BI, B60, S8, Gly, S7, S6, B36, S5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984200000000001" /TUshortSig="Sig-" /TUshortPSig="0.032" /TUlongSig="NA" /TUlongPSig="NA" /label="S1052" CDS complement(2276700..2276822) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513992.1" /db_xref="EnsemblGenomes-Gn:BSU27786" /db_xref="EnsemblGenomes-Tr:CCQ48603" /db_xref="UniProtKB/TrEMBL:L8EAY3" /translation="MEKTYCHSGEKDPEAVYLTVRGYRIKLSPEQMKLISAVRK*" /label="hypothetical protein CDS" gene complement(2276700..2276822) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /label="gene" downshifts complement(2276707) /Source="Nicolas_upshifts" /id="D1422" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="4.39913" /MaxDrop="4.52186" /score="39.5790138" /energy="-18.2" /TU="NA" /idTUdmin="U2149" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(2276870) /Source="Nicolas_upshifts" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2276871..2276888) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2276895..2276902) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2276907..2277197 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390658.2" /db_xref="EnsemblGenomes-Gn:BSU27800" /db_xref="EnsemblGenomes-Tr:CAB14740" /db_xref="SubtiList:BG13818" /db_xref="UniProtKB/Swiss-Prot:O32059" /translation="MNPIYSKMREKKGESHIKTENTLSLDAARGELVNEKTLVKRTIY WNYPDSRPAVTWINHNTVKIGNQTLHLDTDETYDWRKDDHWIREEPPQASVR*" /label="yrzH CDS" gene 2276907..2277197 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /label="yrzH gene" misc_feature 2276918..2276937 /Source="Nicolas_upshift_promotors" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2276918..2277065 /Source="Nicolas_S_feature" /locus_tag="new_2841021_2841168" /HighExp="T3.30H, T4.0H, T3.0H, T2.0H, T2.30H, T5.0H, M9-stat, S7, T1.30H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigA" /TUshortPSig="0.903" /TUlongSig="NA" /TUlongPSig="NA" /label="S1053" upshifts 2276918 /Source="Nicolas_upshifts" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="upshifts" CDS 2277204..2277344 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097769.1" /db_xref="EnsemblGenomes-Gn:BSU27809" /db_xref="EnsemblGenomes-Tr:CAX52675" /db_xref="GOA:C0H464" /db_xref="UniProtKB/Swiss-Prot:C0H464" /translation="MNKMNGTNDEKHFNHFVIALSFIYGLTELGYLLLKDFITIAISL PL*" /label="yrzT CDS" gene 2277204..2277344 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /label="yrzT gene" downshifts 2277333 /Source="Nicolas_upshifts" /id="D1423" /incds=0 /nref=139 /ntot=241 /MaxReadThrough="0.64189" /MaxDrop="4.74983" /score="23.2933855" /energy="-9.9" /TU="NA" /idTUdmin="U2150" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2277393..2277399 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2277407..2277507 /Source="Nicolas_upshift_promotors" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2277414..2277432 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2277415 /Source="Nicolas_upshifts" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="upshifts" upshifts 2277467 /Source="Nicolas_upshifts" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="upshifts" CDS 2277508..2278962 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1400476, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium/proton-dependent alanine transporter" /protein_id="NP_390659.2" /db_xref="EnsemblGenomes-Gn:BSU27810" /db_xref="EnsemblGenomes-Tr:CAB14741" /db_xref="GOA:O32060" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG13784" /db_xref="UniProtKB/Swiss-Prot:O32060" /translation="MADFVASLNAVLWSTPVIYILLGIGFAFSIMTRFLQVRHLKEMI VQMFKGKSSEAGVSSFQALSIALSGRVGTGNIAGVATAIAFGGPGAVFWMWAIAFIGA ASAFVESTLAQIYKVKQDGQYRGGPAYYIEKGLGIKWFAVLFAAAALIAMAFLMPGVQ SNSIAAGIQNAFGISPFVTGCGLVLLLGFIIFGGVKRIANAAQMIVPFMAIGYILLSL IIIVMNVSELPAVISLIFKSAFALDSAFGGLIGMAISWGVKRGIYSNEAGQGTGPHPA AAAEVSHPVKQGLVQAFSVYIDTLFVCSATAFMILFTGMYNTQAADGSFIVHQLKGVE AGPGFTQAAIDSVLPGFGAGFVAIALFFFAFTTIMAYYYIAETNIAYLARGRESKWAM LGLKLIILAATFYGTVKTASLAWALGDAGLGIMVWLNVIAIVLLAKPALLALKDYERQ KKQGLDPIFDPKALGIKNADFWEKEYTHESERVS*" /label="alaP CDS" gene 2277508..2278962 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /label="alaP gene" downshifts 2278963 /Source="Nicolas_upshifts" /id="D1424" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="5.01314" /MaxDrop="4.4617" /score="6.86850608" /energy="-10.8" /TU="U2151" /idTUdmin="U2152" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2279003..2279725) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12060744, 18641136, 20647113; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor regulating gene expression" /protein_id="NP_390660.1" /db_xref="EnsemblGenomes-Gn:BSU27820" /db_xref="EnsemblGenomes-Tr:CAB14742" /db_xref="GOA:P94447" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG13783" /db_xref="UniProtKB/Swiss-Prot:P94447" /translation="MAGHSKWKNIQKRKNAQDAKRGKIFMKLAKEIYVAAKEGGADPE ANSALRLVIEKAKGANMPNENIDRAIKKAAGGQDGSSYEEITYEGYGPSGIAVMVECV TDNKNRTASNVRTAFNKNGGSLGESGCVAFLFERKGFITIDRTERQIEEDELMLDVLE AGGEELRIEEDLYEVFTEPEHFEEVKTALESKYLISSAEVTMLPNTYAEADDQAVEKL ETLIDVLEDDDDVQEVYTNYRS*" /label="yrbC CDS" gene complement(2279003..2279725) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /label="yrbC gene" S_feature 2279008..2279429 /Source="Nicolas_S_feature" /locus_tag="new_2843111_2843532" /HighExp="S8, S6, S7, BT, C30, S5, S4, LoTm, C90, S3" /AntisenseName="yrbC" /AntisenseCor="-8.4330852334841305E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1054" downshifts complement(2279019) /Source="Nicolas_upshifts" /id="D1425" /incds=0 /nref=11 /ntot=164 /MaxReadThrough="3.2014" /MaxDrop="3.66865" /score="23.9031001" /energy="-16" /TU="U2153" /idTUdmin="U2153" /TUdmin="-574" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2279748..2279767) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2279765) /Source="Nicolas_upshifts" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2279781..2279788) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2279828..2280424) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9770294, 10438771, 12562816, 17322312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9770294, 10438771, 12562816, 17322312; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_390661.2" /db_xref="EnsemblGenomes-Gn:BSU27830" /db_xref="EnsemblGenomes-Tr:CAB14743" /db_xref="GOA:P94446" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13782" /db_xref="UniProtKB/Swiss-Prot:P94446" /translation="MGKKMTIASLILMTAGLTACGANDNAMNDTRNNGNTRPIGYYTN ENDADRQGDGIDHDGPVSELMEDQNDGNRNTTNVNNRDRVTADDRVPLATDGTYNNTN NRNMNRNAANNGYDNQENRRLAAKIANRVKQVKNVNDTQVMVSDDRVVIAVKSHREFT KSDRDNVVKAARNYANGRDVQVSTDKGLFRKLHKMNNR*" /label="sgpA CDS" gene complement(2279828..2280424) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /label="sgpA gene" downshifts complement(2279843) /Source="Nicolas_upshifts" /id="D1426" /incds=0 /nref=96 /ntot=172 /MaxReadThrough="2.47709" /MaxDrop="7.18444" /score="23.9031001" /energy="-16" /TU="NA" /idTUdmin="U2154" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2280467..2280478) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2280469) /Source="Nicolas_upshifts" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2280471..2280535) /Source="Nicolas_S_feature" /locus_tag="new_2844574_2844638_c" /HighExp="B36, LoTm, S8, S6, S5, BT, B60, S4, S7, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1055" promotor_-35 complement(2280493..2280499) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2280572..2281735) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10438771, 10714986, 10714992, 11040425, 15901704, 26953338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438771, 10714986, 10714992, 11040425, 15901704, 26953338; Product type f : factor" /codon_start=1 /transl_table=11 /product="morphogenetic protein associated with SpoVID" /protein_id="NP_390662.1" /db_xref="EnsemblGenomes-Gn:BSU27840" /db_xref="EnsemblGenomes-Tr:CAB14744" /db_xref="GOA:O32062" /db_xref="InterPro:IPR014248" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13781" /db_xref="UniProtKB/Swiss-Prot:O32062" /translation="MKIHIVQKGDSLWKIAEKYGVDVEEVKKLNTQLSNPDLIMPGMK IKVPSEGVPVRKEPKAGKSPAAGSVKQEHPYAKEKPKSVVDVEDTKPKEKKSMPYVPP MPNLQENVYPEADVNDYYDMKQLFQPWSPPKPEEPKKHHDGNMDHMYHMQDQFPQQEA MSNMENANYPNMPNMPKAPEVGGIEEENVHHTVPNMPMPAVQPYYHYPAHFVPCPVPV SPILPGSGLCYPYYPAQAYPMHPMHGYQPGFVSPQYDPGYENQHHENSHHGHYGSYGA PQYASPAYGSPYGHMPYGPYYGTPQVMGAYQPAAAHGYMPYKDHDDCGCDGDHQPYFS APGHSGMGAYGSPNMPYGTANPNPNPYSAGVSMPMTNQPSVNQMFGRPEEENE*" /label="safA CDS" gene complement(2280572..2281735) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /label="safA gene" downshifts complement(2280580) /Source="Nicolas_upshifts" /id="D1427" /incds=0 /nref=34 /ntot=189 /MaxReadThrough="5.61903" /MaxDrop="3.9565" /score="38.1347732" /energy="-11.1" /TU="U2155,U2156,U2159" /idTUdmin="U2154" /TUdmin="-749" /isTUend="FALSE" /label="downshifts" S_feature complement(2281736..2281811) /Source="Nicolas_S_feature" /locus_tag="new_2845839_2845914_c" /HighExp="S5, S4, B36, LoTm, S3, B60, S7, S6, Pyr, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1056" promotor_-10 complement(2281787..2281805) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2281811) /Source="Nicolas_upshifts" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2281821..2281826) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2281852..2282958) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /EC_number="2.5.1.72" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15898769, 15937336, 15967443, 18959769, 26455817" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15898769, 15937336, 15967443, 18959769, 26455817; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quinolinate synthetase" /protein_id="NP_390663.1" /db_xref="EnsemblGenomes-Gn:BSU27850" /db_xref="EnsemblGenomes-Tr:CAB14745" /db_xref="GOA:Q9KWZ1" /db_xref="InterPro:IPR003473" /db_xref="InterPro:IPR023515" /db_xref="InterPro:IPR036094" /db_xref="SubtiList:BG12629" /db_xref="UniProtKB/Swiss-Prot:Q9KWZ1" /translation="MSILDVIKQSNDMMPESYKELSRKDMETRVAAIKKKFGSRLFIP GHHYQKDEVIQFADQTGDSLQLAQVAEKNKEADYIVFCGVHFMAETADMLTSEQQTVV LPDMRAGCSMADMADMQQTNRAWKKLQHIFGDTIIPLTYVNSTAEIKAFVGKHGGATV TSSNAKKVLEWAFTQKKRILFLPDQHLGRNTAYDLGIALEDMAVWDPMKDELVAESGH TNVKVILWKGHCSVHEKFTTKNIHDMRERDPDIQIIVHPECSHEVVTLSDDNGSTKYI IDTINQAPAGSKWAIGTEMNLVQRIIHEHPDKQIESLNPDMCPCLTMNRIDLPHLLWS LEQIEKGEPSGVIKVPKAIQEDALLALNRMLSIT*" /label="nadA CDS" gene complement(2281852..2282958) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /label="nadA gene" promotor_-10 complement(2282534..2282552) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2282559) /Source="Nicolas_upshifts" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2282568..2282573) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2282870 /Source="Nicolas_upshifts" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2282871..2282874 /Source="Nicolas_upshift_promotors" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2282945..2283814) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /EC_number="2.4.2.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8419294, 28618168; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)" /protein_id="NP_390664.1" /db_xref="EnsemblGenomes-Gn:BSU27860" /db_xref="EnsemblGenomes-Tr:CAB14746" /db_xref="GOA:P39666" /db_xref="InterPro:IPR002638" /db_xref="InterPro:IPR004393" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022412" /db_xref="InterPro:IPR027277" /db_xref="InterPro:IPR036068" /db_xref="InterPro:IPR037128" /db_xref="SubtiList:BG10868" /db_xref="UniProtKB/Swiss-Prot:P39666" /translation="MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEG IFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEVIAELHGPAAALLSGERVVLNLI QRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGI MIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPP DTVRHFAKLTPANIKTEASGGITLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTL SNESVEECCYVNS*" /label="nadC CDS" gene complement(2282945..2283814) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /label="nadC gene" downshifts 2283039 /Source="Nicolas_upshifts" /id="D1428" /incds=1 /nref=4 /ntot=107 /MaxReadThrough="0.495279999999999" /MaxDrop="3.83418" /score="-8.75482157" /energy="-7.4" /TU="NA" /idTUdmin="U2157" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(2283768..2285363) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /EC_number="1.4.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 16199587, 18959769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 16199587, 18959769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-aspartate oxidase" /protein_id="NP_390665.1" /db_xref="EnsemblGenomes-Gn:BSU27870" /db_xref="EnsemblGenomes-Tr:CAB14747" /db_xref="GOA:P38032" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR005288" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10867" /db_xref="UniProtKB/Swiss-Prot:P38032" /translation="MSKKTIAVIGSGAAALSLAAAFPPSYEVTVITKKSVKNSNSVYA QGGIAAAYAKDDSIEAHLEDTLYAGCGHNNLAIVADVLHDGKMMVQSLLERGFPFDRN ERGGVCLGREGAHSYNRIFHAGGDATGRLLIDYLLKRINSKIKLIENETAADLLIEDG RCIGVMTKDSKGRLKVRHADEVVLAAGGCGNLFLHHTNDLTVTGDGLSLAYRAGAELT DLEFTQFHPTLLVKNGVSYGLVSEAVRGEGGCLVDENGRRIMAERHPLGDLAPRDIVS RVIHEEMAKGNRVYIDFSAISDFETRFPTITAICEKAGIDIHSGKIPVAPGMHFLMGG VSVNRWGETTVPGLYAIGETACSGLHGANRLASNSLLEALVFGKRAAEHIIQKPVYNR QYQSGLETSVFYEVPDIEGHELQSKMTSHMSILREQSSLIELSIWLHTLPFQEVNVKD ITIRQMELSHLWQTAKLMTFSALLREESRGAHFRTDFPHAEVSWQGRQIVHTKKGTKI RKNEGIWNNESFTAEKITESLFS*" /label="nadB CDS" gene complement(2283768..2285363) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /label="nadB gene" promotor_-35 2285391..2285398 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2285391..2285410) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2285412 /Source="Nicolas_upshifts" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2285414..2285433 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2285415) /Source="Nicolas_upshifts" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2285425..2285432) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2285466..2286653 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 14567704, 16199587, 25447671, 26443755, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 14567704, 16199587, 25447671, 26443755, 28882201; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="desulfurase involved in iron-sulfur clusters forNAD biosynthesis" /protein_id="NP_390666.1" /db_xref="EnsemblGenomes-Gn:BSU27880" /db_xref="EnsemblGenomes-Tr:CAB14748" /db_xref="GOA:P38033" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG10866" /db_xref="UniProtKB/Swiss-Prot:P38033" /translation="MIYLDYAATTPICEEALTVYQKLSMDMYGNASSLHDAGGKAKHI LEYCREKIANIIGGEASGIYFTSGGTESNFLAIQSLLNGLPKTKRHFITTAMEHQSIH NCAAFLEQQGYDVTVIEPNEYGLITEEILLTHIRPETGLVSIQHANSETGIIQPIQHL SSYLHNKGILLHCDAVQTFGKIPINTKNLGVDALSMSSHKIHGPKGVGAVYIRPDVPW KPVYPLTTHEYGFRAGTVNVPGIGAFTAAAELIVSEMEKQISRNEALRTYFLDQIRIR SLPVTLAADTSKAECLPHIIGCFFHSFEGQYVMLECNRSNICISTGSACSAGYHGPSE TMKALRKTEQEALQFIRISFGRHTTAEQLEQLLHTFTVLWEQKKGEFDIDRRIKANGR QQA*" /label="nifS CDS" gene 2285466..2286653 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /label="nifS gene" promotor_-10 complement(2285467..2285486) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2285485) /Source="Nicolas_upshifts" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2285501..2285510) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2286368..2286373 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2286382 /Source="Nicolas_upshifts" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2286384..2286403 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2286613..2287155 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16199587, 18276644" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16199587, 18276644; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of de novo NAD biosynthesis" /protein_id="NP_390667.2" /db_xref="EnsemblGenomes-Gn:BSU27890" /db_xref="EnsemblGenomes-Tr:CAB14749" /db_xref="GOA:P39667" /db_xref="InterPro:IPR004173" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026043" /db_xref="InterPro:IPR035922" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10865" /db_xref="UniProtKB/Swiss-Prot:P39667" /translation="MTEELKLMGANRRDQLLLWLKESKSPLTGGELAKKANVSRQVIV QDISLLKAKNVPIIATSQGYVYMDAAAQQHQQAERIIACLHGPERTEEELQLIVDEGV TVKDVKIEHPVYGDLTAAIQVGTRKEVSHFIKKINSTNAAYLSQLTDGVHLHTLTAPD EHRIDQACQALEEAGILIKD*" /label="niaR CDS" gene 2286613..2287155 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /label="niaR gene" downshifts 2287138 /Source="Nicolas_upshifts" /id="D1429" /incds=0 /nref=109 /ntot=246 /MaxReadThrough="3.55509" /MaxDrop="5.04771" /score="15.054047" /energy="-5.6" /TU="U2158" /idTUdmin="U2161" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2287180..2288037) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /EC_number="4.2.1.51" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:104661, 114523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104661, 114523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydratase" /protein_id="NP_390668.1" /db_xref="EnsemblGenomes-Gn:BSU27900" /db_xref="EnsemblGenomes-Tr:CAB14750" /db_xref="GOA:P21203" /db_xref="InterPro:IPR001086" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008242" /db_xref="InterPro:IPR018528" /db_xref="SubtiList:BG10914" /db_xref="UniProtKB/Swiss-Prot:P21203" /translation="MKVGYLGPAATFTHLAVSSCFQNGAEHVAYRTIPECIDAAVAGE VDFAFVPLENALEGSVNLTIDYLIHEQPLPIVGEMTLPIHQHLLVHPSRENAWKELDK IYSHSHAIAQCHKFLHRHFPSVPYEYANSTGAAAKFVSDHPELNIGVIANDMAASTYE LKIVKRDIQDYRDNHTRFVILSPDENISFEVNSKLSSRPKTTLMVMLPQDDQSGALHR VLSAFSWRNLNLSKIESRPTKTGLGHYFFIIDIEKAFDDVLIPGAMQELEALGCKVRL LGAYQSYQL*" /label="pheA CDS" gene complement(2287180..2288037) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /label="pheA gene" S_feature 2287183..2287892 /Source="Nicolas_S_feature" /locus_tag="new_2851286_2851995" /HighExp="S2, T-5.40H, T3.30H, T-4.40H, GM-0.2, GM-0.1, Pyr, T4.0H, T5.0H, GM 10" /AntisenseName="pheA" /AntisenseCor="-0.15664933741609299" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1057" downshifts complement(2287200) /Source="Nicolas_upshifts" /id="D1430" /incds=0 /nref=173 /ntot=247 /MaxReadThrough="1.87872" /MaxDrop="5.15605" /score="13.965695" /energy="-5.6" /TU="NA" /idTUdmin="U2162" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2288054..2288497) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /experiment="publication(s) with functional evidences, PMID:2537815, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2537815, 27260660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of operons hom-thrCB and thrD" /protein_id="NP_390669.1" /db_xref="EnsemblGenomes-Gn:BSU27910" /db_xref="EnsemblGenomes-Tr:CAB14751" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008310" /db_xref="SubtiList:BG10913" /db_xref="UniProtKB/Swiss-Prot:P21204" /translation="MKEETFYLVREDVLPDAMRKTLEVKKLLDRKKADSVADAVQKVD LSRSAFYKYRDAVFPFYTMVKEQIITLFFHLEDRSGALSQLLQAVADSGSNVLSIHQT IPLQGRANVTLSISTSAMEEDIHTLMNKLRKFDFVEKVEILGSGA*" /label="thrR CDS" gene complement(2288054..2288497) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /label="thrR gene" CDS complement(2288558..2289844) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ppGpp-binding GTPase involved in cell portioning, DNA repair and ribosome assembly" /protein_id="NP_390670.1" /db_xref="EnsemblGenomes-Gn:BSU27920" /db_xref="EnsemblGenomes-Tr:CAB14752" /db_xref="GOA:P20964" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR006074" /db_xref="InterPro:IPR006169" /db_xref="InterPro:IPR014100" /db_xref="InterPro:IPR015349" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="InterPro:IPR035101" /db_xref="InterPro:IPR036346" /db_xref="InterPro:IPR036726" /db_xref="PDB:1LNZ" /db_xref="SubtiList:BG10337" /db_xref="UniProtKB/Swiss-Prot:P20964" /translation="MFVDQVKVYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDV VFEVDEGLRTLMDFRYKKHFKAIRGEHGMSKNQHGRNADDMVIKVPPGTVVTDDDTKQ VIADLTEHGQRAVIARGGRGGRGNSRFATPANPAPQLSENGEPGKERYIVLELKVLAD VGLVGFPSVGKSTLLSVVSSAKPKIADYHFTTLVPNLGMVETDDGRSFVMADLPGLIE GAHQGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYDDYLTINQELSEYNLRLTERP QIIVANKMDMPEAAENLEAFKEKLTDDYPVFPISAVTREGLRELLFEVANQLENTPEF PLYDEEELTQNRVMYTMENEEVPFNITRDPDGVFVLSGDSLERLFKMTDFSRDESVKR FARQMRGMGVDEALRERGAKDGDIIRLLEFEFEFID*" /label="obgE CDS" gene complement(2288558..2289844) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /label="obgE gene" CDS complement(2289878..2290456) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation initiation phosphotransferase" /protein_id="NP_390671.1" /db_xref="EnsemblGenomes-Gn:BSU27930" /db_xref="EnsemblGenomes-Tr:CAB14753" /db_xref="GOA:P06535" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR016122" /db_xref="InterPro:IPR037100" /db_xref="PDB:1F51" /db_xref="PDB:1IXM" /db_xref="PDB:2FTK" /db_xref="SubtiList:BG10336" /db_xref="UniProtKB/Swiss-Prot:P06535" /translation="MKDVSKNQEENISDTALTNELIHLLGHSRHDWMNKLQLIKGNLS LQKYDRVFEMIEEMVIDAKHESKLSNLKTPHLAFDFLTFNWKTHYMTLEYEVLGEIKD LSAYDQKLAKLMRKLFHLFDQAVSRESENHLTVSLQTDHPDRQLILYLDFHGAFADPS AFDDIRQNGYEDVDIMRFEITSHECLIEIGLD*" /label="spo0B CDS" gene complement(2289878..2290456) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /label="spo0B gene" S_feature complement(2290457..2290522) /Source="Nicolas_S_feature" /locus_tag="new_2854560_2854625_c" /HighExp="Cold, H2O2, G135, Paraq, G180, Oxctl, G150, C30, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigEF" /TUlongPSig=1 /label="S1058" promotor_-10 complement(2290507..2290526) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2290522) /Source="Nicolas_upshifts" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2290524..2290741) /Source="Nicolas_S_feature" /locus_tag="new_2854627_2854844_c" /HighExp="Cold, G135, H2O2, Paraq, G180, Oxctl, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1059" CDS 2290534..2290656 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513993.1" /translation="MLEKQLFFPEISCSFFLALVDLQPGRTFYVLLLGEHIQWV*" /label="hypothetical protein CDS" gene 2290534..2290656 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /label="gene" promotor_-35 complement(2290540..2290547) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2290777..2291061) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 (BL24)" /protein_id="NP_390672.1" /db_xref="EnsemblGenomes-Gn:BSU27940" /db_xref="EnsemblGenomes-Tr:CAB14754" /db_xref="GOA:P05657" /db_xref="InterPro:IPR001684" /db_xref="InterPro:IPR018261" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10335" /db_xref="UniProtKB/Swiss-Prot:P05657" /translation="MLRLDLQFFASKKGVGSTKNGRDSEAKRLGAKRADGQFVTGGSI LYRQRGTKIYPGENVGRGGDDTLFAKIDGTVKFERFGRDRKKVSVYPVAQ*" /label="rpmA CDS" gene complement(2290777..2291061) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /label="rpmA gene" downshifts complement(2290786) /Source="Nicolas_upshifts" /id="D1431" /incds=0 /nref=212 /ntot=261 /MaxReadThrough="7.39131" /MaxDrop="7.26483" /score="32.4992871" /energy="-12.5" /TU="U2163" /idTUdmin="U2164" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" CDS complement(2291074..2291412) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11567142, 22333191, 25388641, 27435445, 28187498; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 specific N-terminal end cysteine protease" /protein_id="NP_390673.2" /db_xref="EnsemblGenomes-Gn:BSU27950" /db_xref="EnsemblGenomes-Tr:CAB14755" /db_xref="InterPro:IPR007422" /db_xref="InterPro:IPR036764" /db_xref="SubtiList:BG10334" /db_xref="UniProtKB/Swiss-Prot:P26942" /translation="MIQATIRRSHDKGILSFEMTGHANFAEHGQDLVCAGVTAVVFGA VNAVIVLAGFEPLLDIGEDGGYFYFEFPESLDPEARQKAQLLIEGMIVSLETIERDYK DNLRVTTNII*" /label="rppA CDS" gene complement(2291074..2291412) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /label="rppA gene" CDS complement(2291415..2291723) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8223574, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8223574, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L21 (BL20)" /protein_id="NP_390674.1" /db_xref="EnsemblGenomes-Gn:BSU27960" /db_xref="EnsemblGenomes-Tr:CAB14756" /db_xref="GOA:P26908" /db_xref="InterPro:IPR001787" /db_xref="InterPro:IPR018258" /db_xref="InterPro:IPR028909" /db_xref="InterPro:IPR036164" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10333" /db_xref="UniProtKB/Swiss-Prot:P26908" /translation="MYAIIKTGGKQIKVEEGQTVYIEKLAAEAGETVTFEDVLFVGGD NVKVGNPTVEGATVTAKVEKQGRAKKITVFRYKPKKNVHKKQGHRQPYTKVTIEKINA *" /label="rplU CDS" gene complement(2291415..2291723) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /label="rplU gene" misc_RNA complement(2291737..2291812) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /product="ribosomal protein L21 leader mRNA sequence" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27381917" /label="ldlU RNA" gene complement(2291737..2291812) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /label="ldlU gene" promotor_-10 complement(2291824..2291843) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2291844) /Source="Nicolas_upshifts" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2291857..2291864) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2291870..2292736) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /EC_number="3.4.24.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease [proteolysis of pro-sigma(K)]" /protein_id="NP_390675.1" /db_xref="EnsemblGenomes-Gn:BSU27970" /db_xref="EnsemblGenomes-Tr:CAB14757" /db_xref="GOA:P26937" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG10332" /db_xref="UniProtKB/Swiss-Prot:P26937" /translation="MNKWLDLILKIHVHPFLWIIAALGLLTGHMKALLCLLLIVLIHE LGHAALAVFFSWRIKRVFLLPFGGTVEVEEHGNRPLKEEFAVIIAGPLQHIWLQFAAW MLAEVSVIHQHTFELFTFYNLSILFVNLLPIWPLDGGKLLFLLFSKQLPFQKAHRLNL KTSLCFCLLLGCWVLFVIPLQISAWVLFVFLAVSLFEEYRQRHYIHVRFLLERYYGKN RELEKLLPLTVKAEDKVYHVMAEFKRGCKHPIIIEKSGQKLSQLDENEVLHAYFADKR TNSSMEELLLPY*" /label="spoIVFB CDS" gene complement(2291870..2292736) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /label="spoIVFB gene" CDS complement(2292729..2293523) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpoIVFB (stage IV sporulation)" /protein_id="NP_390676.1" /db_xref="EnsemblGenomes-Gn:BSU27980" /db_xref="EnsemblGenomes-Tr:CAB14758" /db_xref="GOA:P26936" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG10331" /db_xref="UniProtKB/Swiss-Prot:P26936" /translation="MSHRADEIRKRLEKRRKQLSGSKRFSTQTVSEKQKPPSWVMVTD QEKHGTLPVYEDNMPTFNGKHPLVKTDSIILKCLLSACLVLVSAIAYKTNIGPVSQIK PAVAKTFETEFQFASASHWFETKFGNPLAFLAPEHKNKEQQIEVGKDLIAPASGKVQQ DFQDNGEGIKVETSSDKIDSVKEGYVVEVSKDSQTGLTVKVQHADNTYSIYGELKDVD VALYDFVDKGKKLGSIKLDDHNKGVYYFAMKDGDKFIDPIQVISFE*" /label="spoIVFA CDS" gene complement(2292729..2293523) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /label="spoIVFA gene" downshifts 2293526 /Source="Nicolas_upshifts" /id="D1432" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="1.00279" /MaxDrop="2.6024" /score="-6.66807377" /energy="-6.9" /TU="NA" /idTUdmin="U2165" /TUdmin="-131" /isTUend="FALSE" /label="downshifts" promotor_no_box 2293532..2293632 /Source="Nicolas_upshift_promotors" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(2293547..2293565) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-10" upshifts complement(2293558) /Source="Nicolas_upshifts" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="upshifts" promotor_-35 complement(2293581..2293586) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-35" upshifts 2293592 /Source="Nicolas_upshifts" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2293635 /Source="Nicolas_upshifts" /id="D1433" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="1.68429" /MaxDrop="7.01891" /score="-6.66807377" /energy="-6.9" /TU="U2165" /idTUdmin="U2165" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(2293670) /Source="Nicolas_upshifts" /id="D1434" /incds=0 /nref=236 /ntot=262 /MaxReadThrough="2.68001" /MaxDrop="5.80551" /score="40.3102023" /energy="-12.6" /TU="U2166" /idTUdmin="U2167" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2293673..2294479) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase activator of MinC" /protein_id="NP_390677.1" /db_xref="EnsemblGenomes-Gn:BSU27990" /db_xref="EnsemblGenomes-Tr:CAB14759" /db_xref="GOA:Q01464" /db_xref="InterPro:IPR002586" /db_xref="InterPro:IPR010223" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10330" /db_xref="UniProtKB/Swiss-Prot:Q01464" /translation="MGEAIVITSGKGGVGKTTTSANLGTALAILGKRVCLVDTDIGLR NLDVVMGLENRIIYDLVDVVEGRCKMHQALVKDKRFDDLLYLMPAAQTSDKTAVAPEQ IKNMVQELKQEFDYVIIDCPAGIEQGYKNAVSGADKAIVVTTPEISAVRDADRIIGLL EQEENIEPPRLVVNRIRNHLMKNGDTMDIDEIVQHLSIDLLGIVADDDEVIKASNHGE PIAMDPKNRASIAYRNIARRILGESVPLQVLEEQNKGMMAKIKSFFGVRS*" /label="minD CDS" gene complement(2293673..2294479) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /label="minD gene" CDS complement(2294481..2295161) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division regulator (septum placement)" /protein_id="NP_390678.1" /db_xref="EnsemblGenomes-Gn:BSU28000" /db_xref="EnsemblGenomes-Tr:CAB14760" /db_xref="GOA:Q01463" /db_xref="InterPro:IPR005526" /db_xref="InterPro:IPR013033" /db_xref="InterPro:IPR036145" /db_xref="PDB:2M4I" /db_xref="SubtiList:BG10329" /db_xref="UniProtKB/Swiss-Prot:Q01463" /translation="MKTKKQQYVTIKGTKNGLTLHLDDACSFDELLDGLQNMLSIEQY TDGKGQKISVHVKLGNRFLYKEQEEQLTELIASKKDLFVHSIDSEVITKKEAQQIREE AEIISVSKIVRSGQVLQVKGDLLLIGDVNPGGTVRAGGNIFVLGSLKGIAHAGFNGNN QAVIAASEMLPTQLRINHVLNRSPDHIQKGNEMECAYLDTDGNMVIERLQHLAHLRPD LTRLEGGM*" /label="minC CDS" gene complement(2294481..2295161) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /label="minC gene" CDS complement(2295214..2295732) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 18156271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 18156271; Product type s: structure" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390679.1" /db_xref="EnsemblGenomes-Gn:BSU28010" /db_xref="EnsemblGenomes-Tr:CAB14761" /db_xref="GOA:Q01467" /db_xref="InterPro:IPR007227" /db_xref="SubtiList:BG10328" /db_xref="UniProtKB/Swiss-Prot:Q01467" /translation="MKRFLLPFVMMLVFSAESIFTDLVHFPFVTDDQVLAPRFLMLVL IFMSAFINQKHAMIYGFIFGFLYDMNYTSLLGVYMFGFAGLCYLASKAFKVLHTNAFV VILIAVLAVCLLEFYVFGIQSLIHKDIMTFNGFVLDRFIPTILLNIAAALILVLPFRL FFMSLKKELRDE*" /label="mreD CDS" gene complement(2295214..2295732) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /label="mreD gene" CDS complement(2295729..2296601) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 17427287, 20623345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 17427287, 20623345; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390680.2" /db_xref="EnsemblGenomes-Gn:BSU28020" /db_xref="EnsemblGenomes-Tr:CAB14762" /db_xref="GOA:Q01466" /db_xref="InterPro:IPR007221" /db_xref="SubtiList:BG10327" /db_xref="UniProtKB/Swiss-Prot:Q01466" /translation="MPNKRLMLLLLCIIILVAMIGFSLKGGRNTTWPEKVIGDTTGVF QNIFHTPAEFFAGIFENINDLKNTYKENERLREKLDGQTQYEAKLQELEEENKSLRDE LGHVKSIKDYKPILATVIARSPDNWAKQVTINKGTQQNVAKDMAVTNEKGALIGKIKS SGLNNFTSAVQLLSDTDRNNRVATKISGKKGSKGYGLIEGYDKEKKRLKMTIIERKDK QDVKKGDLIETSGTGGVFPEGLTIGEVTDIESDSYGLTKVAYVKPAADLTDLNNVIVV NRDVPTVDTEEEGS*" /label="mreC CDS" gene complement(2295729..2296601) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /label="mreC gene" CDS complement(2296632..2297645) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390681.2" /db_xref="EnsemblGenomes-Gn:BSU28030" /db_xref="EnsemblGenomes-Tr:CAB14763" /db_xref="GOA:Q01465" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10326" /db_xref="UniProtKB/Swiss-Prot:Q01465" /translation="MFGIGARDLGIDLGTANTLVFVKGKGIVVREPSVVALQTDTKSI VAVGNDAKNMIGRTPGNVVALRPMKDGVIADYETTATMMKYYINQAIKNKGMFARKPY VMVCVPSGITAVEERAVIDATRQAGARDAYPIEEPFAAAIGANLPVWEPTGSMVVDIG GGTTEVAIISLGGIVTSQSIRVAGDEMDDAIINYIRKTYNLMIGDRTAEAIKMEIGSA EAPEESDNMEIRGRDLLTGLPKTIEITGKEISNALRDTVSTIVEAVKSTLEKTPPELA ADIMDRGIVLTGGGALLRNLDKVISEETKMPVLIAEDPLDCVAIGTGKALEHIHLFKG KTR*" /label="mreB CDS" gene complement(2296632..2297645) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /label="mreB gene" upshifts complement(2297686) /Source="Nicolas_upshifts" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2297698..2297716) /Source="Nicolas_upshift_promotors" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2297737..2298432) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10652786, 17434969, 18556794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved nucleotide-related metabolism protein" /protein_id="NP_390682.1" /db_xref="EnsemblGenomes-Gn:BSU28040" /db_xref="EnsemblGenomes-Tr:CAB14764" /db_xref="GOA:Q02170" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR001405" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR020891" /db_xref="InterPro:IPR025657" /db_xref="SubtiList:BG10325" /db_xref="UniProtKB/Swiss-Prot:Q02170" /translation="MVIHDLPLKLKDFPMKEKPRERLLKVGAENLANHELLAILLRTG TKHESVLDLSNRLLRSFDGLRLLKEASVEELSSIPGIGMVKAIQILAAVELGSRIHKL ANEEHFVIRSPEDGANLVMEDMRFLTQEHFVCLYLNTKNQVIHKRTVFIGSLNSSIVH PREVFKEAFKRSAASFICVHNHPSGDPTPSREDIEVTRRLFECGNLIGIELLDHLVIG DKKFVSLKEKGYL*" /label="ysxA CDS" gene complement(2297737..2298432) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /label="ysxA gene" CDS complement(2298469..2299038) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /EC_number="3.6.1.9" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10841541, 16216582, 21564336, 24210219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10841541, 16216582, 21564336, 24210219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside triphosphate pyrophosphatase; septum formation DNA-binding protein (multicopy associated filamentation)" /protein_id="NP_390683.1" /db_xref="EnsemblGenomes-Gn:BSU28050" /db_xref="EnsemblGenomes-Tr:CAB14765" /db_xref="GOA:Q02169" /db_xref="InterPro:IPR003697" /db_xref="InterPro:IPR029001" /db_xref="PDB:1EX2" /db_xref="PDB:1EXC" /db_xref="PDB:4HEB" /db_xref="SubtiList:BG10324" /db_xref="UniProtKB/Swiss-Prot:Q02169" /translation="MTKPLILASQSPRRKELLDLLQLPYSIIVSEVEEKLNRNFSPEE NVQWLAKQKAKAVADLHPHAIVIGADTMVCLDGECLGKPQDQEEAASMLRRLSGRSHS VITAVSIQAENHSETFYDKTEVAFWSLSEEEIWTYIETKEPMDKAGAYGIQGRGALFV KKIDGDYYSVMGLPISKTMRALRHFDIRA*" /label="maf CDS" gene complement(2298469..2299038) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /label="maf gene" promotor_-10 complement(2298890..2298905) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2298899) /Source="Nicolas_upshifts" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2298918..2298927) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2299077..2299096) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2299093) /Source="Nicolas_upshifts" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2299110..2299116) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2299189) /Source="Nicolas_upshifts" /id="D1435" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="1.92542" /MaxDrop="5.77117" /score="8.94061802" /energy="-7.4" /TU="NA" /idTUdmin="U2169" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2299191..2300189) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16959571, 17376078, 22720735, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16959571, 17376078, 22720735, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spatial and temporal regulator of the dissolution of septal peptidoglycan during engulfment (stage II sporulation)" /protein_id="NP_390684.1" /db_xref="EnsemblGenomes-Gn:BSU28060" /db_xref="EnsemblGenomes-Tr:CAB14766" /db_xref="GOA:P37575" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10912" /db_xref="UniProtKB/Swiss-Prot:P37575" /translation="MKKRKNKKNSKAAEKALKVTINGKEETVYEQETPETEANKSMTF SNWEEKRQAEQEVAASQEHPDEDEFNWDSEEDKVFKEDPKVVPPFQKKKTKLYAKGKT GAAKPVKRVAATIAFAAVIGTGLGLFALNISGNKEASAPASLEDSLGSQTAKAGDTSA DKQTSGAEKQAAQTEGTYKTYAVQAGKFSNEKGAETLTEQLTEKGYSAVSLSKDDGYT YVIAGLASEKEVSQQLGQVLIDSDFEAWGGKELSLSIESDMTDSFKETAELAAKAILD EDITKASVEKIEKSLGETKASETGEKKAILQALKELEDPSAEAGWKAQQELLAVVK*" /label="spoIIB CDS" gene complement(2299191..2300189) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /label="spoIIB gene" promotor_-10 complement(2300236..2300255) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2300244) /Source="Nicolas_upshifts" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2300267..2300274) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2300312) /Source="Nicolas_upshifts" /id="D1436" /incds=0 /nref=1 /ntot=56 /MaxReadThrough="3.18314" /MaxDrop="2.89774" /score="11.209969" /energy="-7.6" /TU="U2170" /idTUdmin="U2170" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS complement(2300323..2301069) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /EC_number="3.4.23.43" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2553669, 9723928, 15849754, 16751195, 16850406, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2553669, 9723928, 15849754, 16751195, 16850406, 16751195; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane prepilin peptidase" /protein_id="NP_390685.2" /db_xref="EnsemblGenomes-Gn:BSU28070" /db_xref="EnsemblGenomes-Tr:CAB14767" /db_xref="GOA:P15378" /db_xref="InterPro:IPR000045" /db_xref="InterPro:IPR010627" /db_xref="SubtiList:BG10323" /db_xref="UniProtKB/Swiss-Prot:P15378" /translation="MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLT PAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTACLFAAAGIRFGISLELFPAVVF ISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVI AAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPL PFAPAIAAGSILAYLYGDSIISFYIKMALG*" /label="comC CDS" gene complement(2300323..2301069) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /label="comC gene" promotor_-10 complement(2301097..2301116) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2301104) /Source="Nicolas_upshifts" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2301131..2301138) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2301209..2302501) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /EC_number="6.3.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2105929, 2985605, 3040739, 6994831, 9098041, 15705579, 22720735, 26443588; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="folyl-polyglutamate synthase" /protein_id="NP_390686.1" /db_xref="EnsemblGenomes-Gn:BSU28080" /db_xref="EnsemblGenomes-Tr:CAB14768" /db_xref="GOA:Q05865" /db_xref="InterPro:IPR001645" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR018109" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10322" /db_xref="UniProtKB/Swiss-Prot:Q05865" /translation="MFTAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAF HVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVN QMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEP LLTVITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHA APFQSLHDACVIFNEEALPAGEQFSFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEW LNKENIAHISDEALRSGLVKAAWPGRLELVQEHPPVYLDGAHNEEGVEKLAETMKQRF ANSRISVVFSALKDKPYQNMIKRLETIAHAIHFASFDFPRASLAKDLYDASEISNKSW SEDPDDVIKFIESKKGSNEIVLITGSLYFISDIRKRLK*" /label="folC CDS" gene complement(2301209..2302501) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /label="folC gene" downshifts complement(2301214) /Source="Nicolas_upshifts" /id="D1437" /incds=0 /nref=1 /ntot=121 /MaxReadThrough="1.66565" /MaxDrop="3.18428" /score="24.7086033" /energy="-14.3" /TU="NA" /idTUdmin="U2171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2302502..2302560) /Source="Nicolas_S_feature" /locus_tag="new_2866605_2866663_c" /HighExp="S0, LBGexp, G150, MG 45, G135, G180, Gly, Oxctl, M0t45, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1060" CDS complement(2302561..2305203) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /EC_number="6.1.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9098041, 11114335, 25310979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 11114335, 25310979; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="valyl-tRNA synthetase" /protein_id="NP_390687.2" /db_xref="EnsemblGenomes-Gn:BSU28090" /db_xref="EnsemblGenomes-Tr:CAB14769" /db_xref="GOA:Q05873" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002303" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR019499" /db_xref="InterPro:IPR033705" /db_xref="InterPro:IPR037118" /db_xref="SubtiList:BG10321" /db_xref="UniProtKB/Swiss-Prot:Q05873" /translation="METNEQTMPTKYDPAAVEKDRYDFWLKGKFFEAGSDQTKEPYSV VIPPPNVTGRLHLGHAWDTTLQDIVTRMKRMQGYDVLWLPGMDHAGIATQAKVEAKLR EEGKSRYDLGREKFLEETWKWKEEYADFIRSQWAKLGLGLDYSRERFTLDEGLSKAVR EVFVKLYEKGLIYRGEYIINWDPATKTALSDIEVIYKDVQGAFYHMSYPLADGSGSIE IATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPIVNREIPIVGDDYVDMEFGSGAV KITPAHDPNDFELGNRHNLERILVMNEDGTMNENALQYQGMDRFECRKKLVKDLQEAG VLFKIEDHMHSVGHSERSGAVVEPYLSTQWFVRMQPLADAAIELQKKEEKVNFVPDRF EKTYLHWMENIRDWCISRQLWWGHRIPAWYHKETGELYVGLEAPEDSENWEQDTDVLD TWFSSALWPFSTMGWPDVTAEDFKRYYPTDVLVTGYDIIFFWVSRMIFQGIEFTGERP FKDVLIHGLIRDEQGRKMSKSLGNGVDPMDVIDKYGADSLRYFLATGSSPGQDLRFSY EKVESTWNFANKIWNASRFALMNMDGMTYDELDLSGEKSVADKWILTRLNETIEHVTQ LADRYEFGEVGRHLYNFIWDDFCDWYIEMAKLPLYGEDEAAKKTTRSILAYVLDQTMR LLHPFMPFLTEEIWQHLPHQGESITVSQWPAVVPEHTDTEAAADMKLLVELIRSVRNI RSEVNTPMSKQVELYIKTSTDEIASRLEANRSYVERFTNPSVLKIGTDIEAVDKAMTA VVSGAEVILPLEGLINIDEEIARLQKEFDKLTKEVERVQKKLGNEGFMKKAPAHVIDE EREKEKDYVAKRDAVQKRMAELKG*" /label="valS CDS" gene complement(2302561..2305203) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /label="valS gene" S_feature complement(2305204..2305262) /Source="Nicolas_S_feature" /locus_tag="new_2869307_2869365_c" /HighExp="G150, G180, LBGexp, Oxctl, G135, dia0, HPh, Lbexp, Paraq, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigEF" /TUshortPSig="1, 0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1061" misc_RNA complement(2305263..2305485) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /product="T-box riboswitch specific of valine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboV RNA" gene complement(2305263..2305485) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /label="tboV gene" downshifts complement(2305306) /Source="Nicolas_upshifts" /id="D1438" /incds=0 /nref=9 /ntot=27 /MaxReadThrough="6.76593" /MaxDrop="4.53149" /score="23.9897385" /energy="-20" /TU="U2171,U2173,U2176" /idTUdmin="U2176" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2305514..2305533) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2305526) /Source="Nicolas_upshifts" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2305528..2305636) /Source="Nicolas_S_feature" /locus_tag="new_2869631_2869739_c" /HighExp="S8, S6, S7, S5, B36, LoTm, S4, S3, BT, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigEF" /TUshortPSig="0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1062" promotor_-35 complement(2305548..2305553) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2305590..2305599 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2305612..2305631 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2305613 /Source="Nicolas_upshifts" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2305629..2305643) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2305636) /Source="Nicolas_upshifts" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2305651..2305655) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2305651..2305842 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097770.1" /db_xref="EnsemblGenomes-Gn:BSU28099" /db_xref="EnsemblGenomes-Tr:CAX52676" /db_xref="GOA:C0H465" /db_xref="UniProtKB/Swiss-Prot:C0H465" /translation="MKKRFSSYSLPPWVRQIRLVSAQVIIPITIFQGIRTIFFPTTFD VLLLAILIFLACALHLEWI*" /label="yszA CDS" gene 2305651..2305842 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /label="yszA gene" CDS complement(2305861..2306886) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16371471, 16390444, 22091839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16371471, 16390444, 22091839; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390688.1" /db_xref="EnsemblGenomes-Gn:BSU28100" /db_xref="EnsemblGenomes-Tr:CAB14770" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014253" /db_xref="SubtiList:BG10347" /db_xref="UniProtKB/Swiss-Prot:P37964" /translation="MEDTQSVLQEYGLTAQFIEPVSPLVWKVYTDYGIFALKKLKEGR GKHFTDHMVAIEEKGFRSFVPVYRTNSGEFFSAGIQYGDIYYLMPWLQFDQEEERDQK HAYLFRETARLHERTAQELKVRRDEIERYYGQTKKKWEQDKIFYEQFVDRAEKEWYLS PFELQAITYFSETISAVNFALERLEDWYESAKEKDVSRVVMNHGSLSIHHFLYNDAGT GYFTNFERASVGPPQNDLLGFYTKMFRGFPKACPECVEWFYGYTKSFPLREAEVSLFL SYMAYPAAMYKVLNGYQTGKRQHEKEECTQLLKAYWQMKNIEPFVMKIHQIEQEKKFQ AENESTS*" /label="cotN CDS" gene complement(2305861..2306886) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /label="cotN gene" downshifts complement(2305891) /Source="Nicolas_upshifts" /id="D1439" /incds=0 /nref=23 /ntot=70 /MaxReadThrough="4.44965" /MaxDrop="6.68961" /score="-7.46388093" /energy="-12.1" /TU="U2176" /idTUdmin="U2176" /TUdmin="-1311" /isTUend="FALSE" /label="downshifts" CDS complement(2306919..2308646) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11325931, 16371471, 16950916, 22773792, 23178679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325931, 16371471, 16950916, 22773792, 23178679; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenetic spore protein (stage VI sporulation)" /protein_id="NP_390689.1" /db_xref="EnsemblGenomes-Gn:BSU28110" /db_xref="EnsemblGenomes-Tr:CAB14771" /db_xref="GOA:P37963" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10346" /db_xref="UniProtKB/Swiss-Prot:P37963" /translation="MPQNHRLQFSVEESICFQKGQEVSELLSISLDPDIRVQEVNDYV SIIGSLELTGEYNIDQNKHTEEIYTDKRFVEQVRKREDGSAELTHCFPVDITIPKNKV SHLQDVFVFIDAFDYQLTDSRILTIQADLAIEGLLDDTQDKEPEIPLYEAPAAFREEE LSEPPAHSVVEEPGASSAEEAVLQHEPPAEPPELFISKAGLREELETEKAESEPPESV ASEPEAREDVKEEEESEELAVPETEVRAESETEESEPEPDPSEIEIQEIVKAKKETAE PAAAIADVREEADSPAETELREHVGAEESPALEAELHSETVIAKEKEETTVSPNHEYA LRQEAQNEEAAQSDQADPALCQEEAEPDEALESVSEAALSIEDSRETASAVYMENDNA DLHFHFNQKTSSEEASQEELPEPAYRTFLPEQEEEDSFYSAPKLLEEEEQEEESFEIE VRKTPSAEEPKEETPFQSFQLPESSETERKETDAVPRVAPAAETKEPQTKESDNSLYL TKLFTKEADEFSRMKICIVQQEDTIERLCERYEITSQQLIRMNSLALDDELKAGQILY IPQYKNSHA*" /label="spoVID CDS" gene complement(2306919..2308646) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /label="spoVID gene" promotor_-35 2308248..2308251 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2308267..2308286 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2308273 /Source="Nicolas_upshifts" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2308642..2308646 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2308655..2308669 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2308669 /Source="Nicolas_upshifts" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2308684..2308702) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-10" upshifts complement(2308700) /Source="Nicolas_upshifts" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="upshifts" promotor_-35 complement(2308718..2308723) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-35" CDS complement(2308777..2310069) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 12029044, 15802251, 16682782, 20946885, 27303897" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 12029044, 15802251, 16682782, 20946885, 27303897; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde 2,1-aminomutase" /protein_id="NP_390690.1" /db_xref="EnsemblGenomes-Gn:BSU28120" /db_xref="EnsemblGenomes-Tr:CAB14772" /db_xref="GOA:P30949" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3BS8" /db_xref="SubtiList:BG10345" /db_xref="UniProtKB/Swiss-Prot:P30949" /translation="MRSYEKSKTAFKEAQKLMPGGVNSPVRAFKSVDMDPIFMERGKG SKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPTEVENELAKLV IDRVPSVEIVRMVSSGTEATMSALRLARGYTGRNKILKFEGCYHGHGDSLLIKAGSGV ATLGLPDSPGVPEGIAKNTITVPYNDLESVKLAFQQFGEDIAGVIVEPVAGNMGVVPP QEGFLQGLRDITEQYGSLLIFDEVMTGFRVDYNCAQGYFGVTPDLTCLGKVIGGGLPV GAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQLTPESYKNFIKKGDRLE EGISKTAGAHGIPHTFNRAGSMIGFFFTNEPVINYETAKSSDLKLFASYYKGMANEGV FLPPSQFEGLFLSTAHTDEDIENTIQAAEKVFAEISRR*" /label="hemL CDS" gene complement(2308777..2310069) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /label="hemL gene" downshifts complement(2308794) /Source="Nicolas_upshifts" /id="D1440" /incds=0 /nref=144 /ntot=397 /MaxReadThrough="3.40168" /MaxDrop="7.29251" /score="3.77738386" /energy="-10.6" /TU="NA" /idTUdmin="U2177" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2310099..2311073) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /EC_number="4.2.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 12029044, 15802251, 20823524, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 12029044, 15802251, 20823524, 24598743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-aminolevulinic acid dehydratase (porphobilinogen synthase)" /protein_id="NP_390691.1" /db_xref="EnsemblGenomes-Gn:BSU28130" /db_xref="EnsemblGenomes-Tr:CAB14773" /db_xref="GOA:P30950" /db_xref="InterPro:IPR001731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR030656" /db_xref="SubtiList:BG10344" /db_xref="UniProtKB/Swiss-Prot:P30950" /translation="MSQSFNRHRRLRTSKAMREMVKETRLHPSDFIYPIFVVEGLEGK KAVPSMPDVHHVSLDLLKDEVAELVKLGIQSVIVFGIPEEKDDCGTQAYHDHGIVQKA ITEIKEHFPEMVVVADTCLCEYTDHGHCGLVKDGVILNDESLELLAQTAVSQAKAGAD IIAPSNMMDGFVTVIREALDKEGFVNIPIMSYAVKYSSEFYGPFRDAANSTPQFGDRK TYQMDPANRMEALREAQSDVEEGADFLIVKPSLSYMDIMRDVKNEFTLPLVAYNVSGE YSMVKAAAQNGWIKEKEIVLEILTSMKRAGADLIITYHAKDAAKWLAE*" /label="hemB CDS" gene complement(2310099..2311073) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /label="hemB gene" CDS complement(2311070..2311858) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /EC_number="4.2.1.75" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 2110138, 7628476, 12029044, 12196144, 15802251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 2110138, 7628476, 12029044, 12196144, 15802251; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III cosynthase" /protein_id="NP_390692.1" /db_xref="EnsemblGenomes-Gn:BSU28140" /db_xref="EnsemblGenomes-Tr:CAB14774" /db_xref="GOA:P21248" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG10343" /db_xref="UniProtKB/Swiss-Prot:P21248" /translation="MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFR RALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTAR RLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEV KEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTA CISIGPLTNDALLTYGITSHTPDTFTIDGMLELMCSMSREEERI*" /label="hemD CDS" gene complement(2311070..2311858) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /label="hemD gene" CDS complement(2311848..2312792) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /EC_number="2.5.1.61" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 9058548, 12029044, 15802251, 23908040, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 9058548, 12029044, 15802251, 23908040, 24598743; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="porphobilinogen deaminase (hydroxymethylbilane synthase)" /protein_id="NP_390693.1" /db_xref="EnsemblGenomes-Gn:BSU28150" /db_xref="EnsemblGenomes-Tr:CAB14775" /db_xref="GOA:P16616" /db_xref="InterPro:IPR000860" /db_xref="InterPro:IPR022417" /db_xref="InterPro:IPR022418" /db_xref="InterPro:IPR022419" /db_xref="InterPro:IPR036803" /db_xref="SubtiList:BG10342" /db_xref="UniProtKB/Swiss-Prot:P16616" /translation="MMRTIKVGSRRSKLAMTQTKWVIQKLKEINPSFAFEIKEIVTKG DRIVDVTLSKVGGKGLFVKEIEQALLNEEIDMAVHSMKDMPAVLPEGLVIGCIPERED PRDALISKNRVKLSEMKKGAVIGTSSLRRSAQLLIERPDLTIKWIRGNIDTRLQKLET EDYDAIILAAAGLSRMGWKQDVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQ FTDEYTKRTVLAERAFLNAMEGGCQVPIAGYSVLNGQDEIEMTGLVASPDGKIIFKET VTGNDPEEVGKRCAALMADKGAKDLIDRVKRELDEDGK*" /label="hemC CDS" gene complement(2311848..2312792) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /label="hemC gene" CDS complement(2312825..2313655) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8012594, 12029044, 15802251, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012594, 12029044, 15802251, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="negative effector of the concentration of glutamyl-tRNA reductase HemA" /protein_id="NP_390694.2" /db_xref="EnsemblGenomes-Gn:BSU28160" /db_xref="EnsemblGenomes-Tr:CAB14776" /db_xref="GOA:P16645" /db_xref="InterPro:IPR002541" /db_xref="SubtiList:BG10341" /db_xref="UniProtKB/Swiss-Prot:P16645" /translation="MIDTAMARLNEGTIVIYALSVLFYFIDFLQHNRKAGKMAFWLLS IVWTLQTVYLAYFMWVTGRFPVLNVTEALYFYAWVLVTLSLVLTKLLRVDFIVFFTNV IGFSMIAIHTFSPTEQQSAAFSGQLVSELLVIHITMAILSYGAFSLSFVFSVLYMFQY HLLKKKKWGKWLLRIEDLSKLDYMAYVLNVIGVPMLLLSLILGVIWAYVSLETLYWFD AKVLGSFVVLLLYSYYLYIRLIKELQGKVAALWNTACFLVLMINYFLLGSLSQFHWFS *" /label="hemX CDS" gene complement(2312825..2313655) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /label="hemX gene" CDS complement(2313663..2315030) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /EC_number="1.2.1.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1536660, 15802251, 1672867, 2490162, 12029044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1536660, 15802251, 1672867, 2490162, 12029044; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA reductase" /protein_id="NP_390695.1" /db_xref="EnsemblGenomes-Gn:BSU28170" /db_xref="EnsemblGenomes-Tr:CAB14777" /db_xref="GOA:P16618" /db_xref="InterPro:IPR000343" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR015895" /db_xref="InterPro:IPR015896" /db_xref="InterPro:IPR018214" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036343" /db_xref="InterPro:IPR036453" /db_xref="SubtiList:BG10340" /db_xref="UniProtKB/Swiss-Prot:P16618" /translation="MHILVVGVDYKSAPIEIREKVSFQPNELAEAMVQLKEEKSILEN IIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLSKEELSPFLTFYESDAAVEHLFR VACGLDSMVIGETQILGQVRDSFKTAQQEKTIGTIFNELFKQAVTVGKRTHAETDIGS NAVSVSYAAVELAKKIFGNLSSKHILILGAGKMGELAAENLHGQGIGKVTVINRTYLK AKELADRFSGEARSLNQLESALAEADILISSTGASEFVVSKEMMENANKLRKGRPLFM VDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANMKERRETAEKVELLIEETIVEFKQ WMNTLGVVPVISALREKALAIQSETMDSIERKLPHLSTREKKLLNKHTKSIINQMLRD PILKVKELAADADSEEKLALFMQIFDIEEAAGRQMMKTVESSQKVHSFKKAESKAGFS PLVSE*" /label="hemA CDS" gene complement(2313663..2315030) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /label="hemA gene" misc_feature complement(2315094..2315113) /Source="Nicolas_upshift_promotors" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2315100) /Source="Nicolas_upshifts" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2315102..2315191) /Source="Nicolas_S_feature" /locus_tag="new_2879205_2879294_c" /HighExp="dia15, Salt, dia5, Etha, Paraq, H2O2, Diami, Heat, LoTm, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigGF" /TUshortPSig="0.997, 1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1063" misc_feature 2315151..2315170 /Source="Nicolas_upshift_promotors" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2315159 /Source="Nicolas_upshifts" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2315188..2315207) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2315191) /Source="Nicolas_upshifts" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2315193..2315609) /Source="Nicolas_S_feature" /locus_tag="new_2879296_2879712_c" /HighExp="Etha, S5, Gly, S7, S4, S8, S6, H2O2, dia15, G135" /AntisenseName="ysxD" /AntisenseCor="-1.16761021676615E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF" /TUshortPSig="1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1064" promotor_-35 complement(2315218..2315226) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2315260..2315757 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390696.2" /db_xref="EnsemblGenomes-Gn:BSU28180" /db_xref="EnsemblGenomes-Tr:CAB14778" /db_xref="GOA:P40736" /db_xref="SubtiList:BG11068" /db_xref="UniProtKB/Swiss-Prot:P40736" /translation="MKQKSILFPCLLLAASVYAWLESGQAELFSGQDQWPVLLMLLGA AFVYQGKKEAVTPHFFIGLLLFGIGLHFFAKPKWVWWPDDFEMLLFMIGFSLLVSTVQ KKEYVYEAVSMICFSLFLYFFKQIMAWLESAHIPTALLKEYWPFVFIGISLLLLLIKR KKSIR*" /label="ysxD CDS" gene 2315260..2315757 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /label="ysxD gene" promotor_-10 complement(2315593..2315611) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2315609) /Source="Nicolas_upshifts" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2315611..2315741) /Source="Nicolas_S_feature" /locus_tag="new_2879714_2879844_c" /HighExp="S5, S4, S8, S6, H2O2, S7, Etha, dia15, Diami, G180" /AntisenseName="ysxD" /AntisenseCor="-1.18079537254433E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1065" promotor_-35 complement(2315627..2315633) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2315721..2315732) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-10" upshifts complement(2315741) /Source="Nicolas_upshifts" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="upshifts" promotor_-35 complement(2315747..2315753) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-35" CDS complement(2315779..2316366) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome 50S subunit assembly(maturation of the central 50S protuberance)" /protein_id="NP_390697.1" /db_xref="EnsemblGenomes-Gn:BSU28190" /db_xref="EnsemblGenomes-Tr:CAB14779" /db_xref="GOA:P38424" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019987" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030393" /db_xref="PDB:1SUL" /db_xref="PDB:1SVI" /db_xref="PDB:1SVW" /db_xref="SubtiList:BG10339" /db_xref="UniProtKB/Swiss-Prot:P38424" /translation="MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLI NRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITT REELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVR QTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR*" /label="engB CDS" gene complement(2315779..2316366) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /label="engB gene" downshifts complement(2315807) /Source="Nicolas_upshifts" /id="D1441" /incds=0 /nref=78 /ntot=212 /MaxReadThrough="4.03888" /MaxDrop="6.16077" /score="19.8235959" /energy="-13.4" /TU="NA" /idTUdmin="U2182" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2316363..2318687) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /EC_number="3.4.21.53" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="class III heat-shock ATP-dependent LonA protease" /protein_id="NP_390698.1" /db_xref="EnsemblGenomes-Gn:BSU28200" /db_xref="EnsemblGenomes-Tr:CAB14780" /db_xref="GOA:P37945" /db_xref="InterPro:IPR003111" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004815" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027543" /db_xref="PDB:1X37" /db_xref="PDB:3M65" /db_xref="PDB:3M6A" /db_xref="SubtiList:BG10338" /db_xref="UniProtKB/Swiss-Prot:P37945" /translation="MAEELKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMH DHMIFLATQQDISIDEPGEDEIFTVGTYTKIKQMLKLPNGTIRVLVEGLKRAHIVKYN EHEDYTSVDIQLIHEDDSKDTEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEP GRMADIVASHLPLKLKDKQDILETADVKDRLNKVIDFINNEKEVLEIEKKIGQRVKRS MERTQKEYYLREQMKAIQKELGDKEGKTGEVQTLTEKIEEAGMPDHVKETALKELNRY EKIPSSSAESSVIRNYIDWLVALPWTDETDDKLDLKEAGRLLDEEHHGLEKVKERILE YLAVQKLTKSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGH RRTYVGAMPGRIIQGMKKAGKLNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSSF SDHYIEETFDLSKVLFIATANNLATIPGPLRDRMEIINIAGYTEIEKLEIVKDHLLPK QIKEHGLKKSNLQLRDQAILDIIRYYTREAGVRSLERQLAAICRKAAKAIVAEERKRI TVTEKNLQDFIGKRIFRYGQAETEDQVGVVTGLAYTTVGGDTLSIEVSLSPGKGKLIL TGKLGDVMRESAQAAFSYVRSKTEELGIEPDFHEKYDIHIHVPEGAVPKDGPSAGITM ATALVSALTGRAVSREVGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEK DIEDIPESVREGLTFILASHLDEVLEHALVGEKK*" /label="lonA CDS" gene complement(2316363..2318687) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /label="lonA gene" S_feature complement(2318688..2318799) /Source="Nicolas_S_feature" /locus_tag="new_2882791_2882902_c" /HighExp="Etha, dia15, LBGtran, dia5, Diami, H2O2, LBGexp, Lbexp, LoTm, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.967" /TUlongSig="NA" /TUlongPSig="NA" /label="S1066" promotor_-10 complement(2318784..2318803) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2318799) /Source="Nicolas_upshifts" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2318817..2318824) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2318868..2320526) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 18689473, 26428922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 18689473, 26428922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific ATP-dependent protease LonB" /protein_id="NP_390699.1" /db_xref="EnsemblGenomes-Gn:BSU28210" /db_xref="EnsemblGenomes-Tr:CAB14781" /db_xref="GOA:P42425" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014251" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11077" /db_xref="UniProtKB/Swiss-Prot:P42425" /translation="MSWTGIALFIQLFFGIIIGLYFWNLLKNQRTQKVTIDKESKKEM EQLRKMRAISLSEPLSEKVRPKSFKDIVGQEDGIKALKAALCGPNPQHVIVYGPPGVG KTAAARLVLEEAKKHKQSPFKEQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEE NTQIPNHIHDIFQNGLPADFRLIGATTRMPNEIPPAIRSRCLEVFFRELEKDELKTVA KTAADKIEKNISEEGLDLLTSYTRNGREAVNMIQIAAGMAVTENRKDITIEDIEWVIH SSQLTPKHEQKIGVEPQVGIVNGLAVYGPNSGSLLEIEVSVTAAQDKGSINITGIAEE ESIGSQSKSIRRKSMAKGSVENVLTVLRTMGMKPSDYDIHINFPGGIPIDGPSAGIAM AAGIFSAIHKIPIDNTVAMTGEISLNGLVKPIGGVIPKIKAAKQSGAKKVIIPYENQQ AILKQIDGIEIIAVKTFQEVLDEILVNPPTEQKPFHIEINKESV*" /label="lonB CDS" gene complement(2318868..2320526) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /label="lonB gene" downshifts complement(2318887) /Source="Nicolas_upshifts" /id="D1442" /incds=0 /nref=24 /ntot=42 /MaxReadThrough="2.32825" /MaxDrop="4.82102" /score="7.30551887" /energy="-7.1" /TU="NA" /idTUdmin="U2183" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2320570..2320588) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2320581) /Source="Nicolas_upshifts" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2320604..2320609) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2320678..2321940) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein unfolding ATPase required for presentation of proteins to proteases; Maxwell's demon" /protein_id="NP_390700.2" /db_xref="EnsemblGenomes-Gn:BSU28220" /db_xref="EnsemblGenomes-Tr:CAB14782" /db_xref="GOA:P50866" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004487" /db_xref="InterPro:IPR010603" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11387" /db_xref="UniProtKB/Swiss-Prot:P50866" /translation="MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTE IVEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKV DDVELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILL KLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVAS VPPQGGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGADNKAADLE KEDLLSKVLPEDLLRFGLIPEFIGRLPVIASLEKLDEEALVAILTKPKNALVKQFKKM LELDNVELEFEEEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFELPSRDDIEKCVI TGATVTHGEPPRLLLKDGTEVSQDKTSA*" /label="clpX CDS" gene complement(2320678..2321940) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /label="clpX gene" downshifts complement(2320688) /Source="Nicolas_upshifts" /id="D1443" /incds=0 /nref=256 /ntot=333 /MaxReadThrough="2.8818" /MaxDrop="7.82186" /score="40.299167" /energy="-18.9" /TU="U2185" /idTUdmin="U2184" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2321941..2322030) /Source="Nicolas_S_feature" /locus_tag="new_2886044_2886133_c" /HighExp="dia15, dia5, Salt, Diami, C90, H2O2, Paraq, Oxctl, S1, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="1, 0.998, 0.896" /label="S1067" promotor_-10 complement(2322018..2322037) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2322030) /Source="Nicolas_upshifts" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2322032..2322163) /Source="Nicolas_S_feature" /locus_tag="new_2886135_2886266_c" /HighExp="H2O2, dia15, Paraq, Oxctl, G180, G135, HPh, G150, LPh, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1068" promotor_-35 complement(2322049..2322056) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2322208) /Source="Nicolas_upshifts" /id="D1444" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="8.26501" /MaxDrop="4.34985" /score="-0.284489083" /energy="-10.7" /TU="U2185,U2190" /idTUdmin="U2190" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" CDS complement(2322212..2323486) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9748346, 12224648, 16156784, 17021213" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9748346, 12224648, 16156784, 17021213; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl isomerase (trigger factor)" /protein_id="NP_390701.1" /db_xref="EnsemblGenomes-Gn:BSU28230" /db_xref="EnsemblGenomes-Tr:CAB14783" /db_xref="GOA:P80698" /db_xref="InterPro:IPR001179" /db_xref="InterPro:IPR005215" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR008881" /db_xref="InterPro:IPR027304" /db_xref="InterPro:IPR036611" /db_xref="SubtiList:BG19023" /db_xref="UniProtKB/Swiss-Prot:P80698" /translation="MSVKWEKQEGNEGVLTVEVDAETFKTALDDAFKKVVKQVSIPGF RKGKIPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIEKGE SLIFTAKVTVKPEVKLGEYKGLGIEKDDTTVTDEDVQNELKALQERQAELVVKEEGAV EEGNTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEDQLVGLEAGAEKDVEVT FPEEYHAEDLAGKPAVFKVKIHEIKAKELPELDDEFAKDIDEEVETLAELTEKTKKRL EEAKENEADAKLREELVLKASENAEIDVPQAMVDTELDRMLKEFEQRLQMQGMNLELY TQFSGQDEAALKEQMKEDAEKRVKSNLTLEAIAKAENLEVSDEEVDAELTKMAEAYNM PVENIKQAIGSTDAMKEDLKVRKAIDFLVENR*" /label="tig CDS" gene complement(2322212..2323486) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /label="tig gene" S_feature complement(2323487..2323676) /Source="Nicolas_S_feature" /locus_tag="new_2887590_2887779_c" /HighExp="H2O2, HPh, BMM, dia15, T-4.40H, G180, Paraq, Oxctl, LBGexp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1069" promotor_-10 complement(2323663..2323682) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2323676) /Source="Nicolas_upshifts" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2323697..2323701) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2323714..2324718) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390702.2" /db_xref="EnsemblGenomes-Gn:BSU28240" /db_xref="EnsemblGenomes-Tr:CAB14784" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12338" /db_xref="UniProtKB/Swiss-Prot:P94569" /translation="MTHDKKNAKIIPFPHLKDRLVEKGMSSLKEKKYQEALELFSEAM KYDDTESDLHLGMAICFLELGELEEAESVCEKMLKEGYGHYFTVLQVYMTILIQLKKY EEVKSTIEAVLEENQLPAESAEQFYKLLDFSRKMTDPDREDEAWAEEYEDTIDTEKVL ASPEEQMNLIHSLKDRNVAKYTGLLKTILQDPSAHPIIKTMIVMLLAEHEYSKPVHIS KFGESLTIEPSEIVPPDAAPILHRVLRVLDETLGNENPTLYAAVEELWRRHLYVLYPF QPKLLSADLWAAALHKVGYEMHGIEIESEELHMMYEFTDRELDEACTMLKDIEEISYL *" /label="ysoA CDS" gene complement(2323714..2324718) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /label="ysoA gene" promotor_-10 complement(2324743..2324762) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2324761) /Source="Nicolas_upshifts" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2324774..2324781) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" CDS complement(2324837..2325436) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (small subunit)" /protein_id="NP_390703.1" /db_xref="EnsemblGenomes-Gn:BSU28250" /db_xref="EnsemblGenomes-Tr:CAB14785" /db_xref="GOA:P94568" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR004431" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR033940" /db_xref="SubtiList:BG11950" /db_xref="UniProtKB/Swiss-Prot:P94568" /translation="MEPLKSHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFF DWRYDANGEPNPEFELNQPVYQGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPS FADIFHQNCFKNGMLPIRMPYDNWKQLVGQYENQSLQMTVDLENQLIHDSEGNQISFE VDPHWKEMLINGYDEISLTLLLEDEIKQFESQRSSWLQA*" /label="leuD CDS" gene complement(2324837..2325436) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /label="leuD gene" downshifts complement(2324858) /Source="Nicolas_upshifts" /id="D1445" /incds=0 /nref=5 /ntot=111 /MaxReadThrough="6.76876" /MaxDrop="3.81278" /score="12.2084487" /energy="-9.9" /TU="U2190,U2191" /idTUdmin="U2186" /TUdmin="-1176" /isTUend="FALSE" /label="downshifts" CDS complement(2325449..2326867) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (large subunit)" /protein_id="NP_390704.1" /db_xref="EnsemblGenomes-Gn:BSU28260" /db_xref="EnsemblGenomes-Tr:CAB14786" /db_xref="GOA:P80858" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR004430" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR033941" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG11949" /db_xref="UniProtKB/Swiss-Prot:P80858" /translation="MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEG LRQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHS VDQGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQ QRPKTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMT VCNMSIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFDKAVEEWKALRTDPGAVYDKS IVLDGNKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKI EDIKVEHVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLD QIFLEAGFEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMA AMAAIHGHFVDVRKFYQEKTVV*" /label="leuC CDS" gene complement(2325449..2326867) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /label="leuC gene" promotor_-35 2326756..2326760 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2326775..2326779 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2326775 /Source="Nicolas_upshifts" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2326917..2328014) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /EC_number="1.1.1.85" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10095787, 15228537, 15916605, 17389690" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10095787, 15228537, 15916605, 17389690; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydrogenase" /protein_id="NP_390705.2" /db_xref="EnsemblGenomes-Gn:BSU28270" /db_xref="EnsemblGenomes-Tr:CAB14787" /db_xref="GOA:P05645" /db_xref="InterPro:IPR004429" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG10675" /db_xref="UniProtKB/Swiss-Prot:P05645" /translation="MKKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIG GAAIDEHHNPLPEETVAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLF ANLRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVD TLFYKRTEIERVIREGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAQEFPDVKL EHMLVDNAAMQLIYAPNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHL FEPVHGSAPDIAGKGMANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTR DLARSEEFSSTQAITEEVKAAIMSENTISNV*" /label="leuB CDS" gene complement(2326917..2328014) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /label="leuB gene" CDS complement(2328035..2329591) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /EC_number="2.3.3.13" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 16330546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-isopropylmalate synthase" /protein_id="NP_390706.1" /db_xref="EnsemblGenomes-Gn:BSU28280" /db_xref="EnsemblGenomes-Tr:CAB14788" /db_xref="GOA:P94565" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR002034" /db_xref="InterPro:IPR005671" /db_xref="InterPro:IPR013709" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036230" /db_xref="SubtiList:BG11948" /db_xref="UniProtKB/Swiss-Prot:P94565" /translation="MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEA GFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATS DIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDA GASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIE NGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLT GMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRH AFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEF LSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDY RIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMS GLKNHTAVGS*" /label="leuA CDS" gene complement(2328035..2329591) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /label="leuA gene" promotor_-35 2328431..2328434 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2328447..2330888 /Source="Nicolas_S_feature" /locus_tag="new_2892550_2894991" /HighExp="Lbstat, C30, T0.30H, M9-stat, T1.30H, H2O2, M0t90, T2.0H, Salt, BC" /AntisenseName="ilvC" /AntisenseCor="-0.51305153097242795" /AntisenseRegPval="-18.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1070" upshifts 2328447 /Source="Nicolas_upshifts" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2328449..2328468 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2329578..2330606) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /EC_number="1.1.1.86" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 25393291, 25849365; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid isomeroreductase (NADP-dependent)" /protein_id="NP_390707.1" /db_xref="EnsemblGenomes-Gn:BSU28290" /db_xref="EnsemblGenomes-Tr:CAB14789" /db_xref="GOA:P37253" /db_xref="InterPro:IPR000506" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013023" /db_xref="InterPro:IPR013116" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR014359" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10672" /db_xref="UniProtKB/Swiss-Prot:P37253" /translation="MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVI VGVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKS LVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEA RDKALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGY QPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKE VLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKE AVVSVAQN*" /label="ilvC CDS" gene complement(2329578..2330606) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /label="ilvC gene" CDS complement(2330630..2331148) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (small subunit)" /protein_id="NP_390708.2" /db_xref="EnsemblGenomes-Gn:BSU28300" /db_xref="EnsemblGenomes-Tr:CAB14790" /db_xref="GOA:P37252" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004789" /db_xref="InterPro:IPR019455" /db_xref="SubtiList:BG10671" /db_xref="UniProtKB/Swiss-Prot:P37252" /translation="MKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETAGVS RITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSTRTEI NGIIEPFRASVVDVSRDSIVVQVTGESNKIEALIELLKPYGIKEIARTGTTAFARGTQ QKASSNKTISIV*" /label="ilvH CDS" gene complement(2330630..2331148) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /label="ilvH gene" promotor_-35 2330869..2330872 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2330888..2330892 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2330890 /Source="Nicolas_upshifts" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2331145..2332869) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (large subunit)" /protein_id="NP_390709.1" /db_xref="EnsemblGenomes-Gn:BSU28310" /db_xref="EnsemblGenomes-Tr:CAB14791" /db_xref="GOA:P37251" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012846" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10670" /db_xref="UniProtKB/Swiss-Prot:P37251" /translation="MGTNVQVDSASAECTQTMSGALMLIESLKKEKVEMIFGYPGGAV LPIYDKLYNSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADA MIDSLPLVVFTGQVATSVIGSDAFQEADILGITMPVTKHSYQVRQPEDLPRIIKEAFH IATTGRPGPVLIDIPKDVATIEGEFSYDHEMNLPGYQPTTEPNYLQIRKLVEAVSSAK KPVILAGAGVLHGKASEELKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYT ANMALHECDLLISIGARFDDRVTGNLKHFARNAKIAHIDIDPAEIGKIMKTQIPVVGD SKIVLQELIKQDGKQSDSSEWKKQLAEWKEEYPLWYVDNEEEGFKPQKLIEYIHQFTK GEAIVATDVGQHQMWSAQFYPFQKADKWVTSGGLGTMGFGLPAAIGAQLAEKDATVVA VVGDGGFQMTLQELDVIRELNLPVKVVILNNACLGMVRQWQEIFYEERYSESKFASQP DFVKLSEAYGIKGIRISSEAEAKEKLEEALTSREPVVIDVRVASEEKVFPMVAPGKGL HEMVGVKP*" /label="ilvB CDS" gene complement(2331145..2332869) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /label="ilvB gene" S_feature complement(2332870..2332990) /Source="Nicolas_S_feature" /locus_tag="new_2896973_2897093_c" /HighExp="T-5.40H, T-4.40H, S2, MG 120, Glucon, GM-0.2, T-2.40H, GM-0.1, HiOs, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1071" misc_RNA complement(2332991..2333237) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /product="T-box controlling synthesis of branched chain amino acids" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboILV RNA" gene complement(2332991..2333237) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /label="tboILV gene" downshifts complement(2333034) /Source="Nicolas_upshifts" /id="D1446" /incds=0 /nref=18 /ntot=78 /MaxReadThrough="7.67475" /MaxDrop="4.2339" /score="5.33237345" /energy="-13.8" /TU="U2190,U2191" /idTUdmin="U2195" /TUdmin=2682 /isTUend="FALSE" /label="downshifts" S_feature complement(2333238..2333364) /Source="Nicolas_S_feature" /locus_tag="new_2897341_2897467_c" /HighExp="LoTm, HiOs, T-3.40H, BC, B60, Pyr, GM 15, T-5.40H, UNK1, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1072" promotor_-10 complement(2333346..2333365) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-10" upshifts complement(2333364) /Source="Nicolas_upshifts" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="upshifts" S_feature complement(2333366..2333496) /Source="Nicolas_S_feature" /locus_tag="new_2897469_2897599_c" /HighExp="Cold, S8, S0, S7, Mal, S6, G135, M9-stat, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1073" promotor_-35 complement(2333380..2333387) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-35" promotor_-10 complement(2333491..2333510) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2333500) /Source="Nicolas_upshifts" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2333524..2333527) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" promotor_-35 2333622..2333631 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2333645..2333664 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2333647 /Source="Nicolas_upshifts" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="upshifts" CDS 2333685..2334020 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_390710.1" /db_xref="EnsemblGenomes-Gn:BSU28320" /db_xref="EnsemblGenomes-Tr:CAB14792" /db_xref="SubtiList:BG12335" /db_xref="UniProtKB/Swiss-Prot:P94563" /translation="MNKSFADMQGFPAGFPSFPNFPQQYYPAVPPFYQQSQQPFGGYG YGQPFSQAYSPLTTPSGMYSSFPYASGFYGQQFSGAGFSGHGGSLSAPAIHAGGFSGA PGVHGGFRY*" /label="cotQ CDS" gene 2333685..2334020 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /label="cotQ gene" downshifts 2334014 /Source="Nicolas_upshifts" /id="D1447" /incds=0 /nref=14 /ntot=36 /MaxReadThrough="3.79194" /MaxDrop="6.48183" /score="11.836855" /energy="-13" /TU="U2192" /idTUdmin="U2193" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-35 2334101..2334108 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2334122..2334141 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2334124..2334188 /Source="Nicolas_S_feature" /locus_tag="new_2898227_2898291" /HighExp="S5, S6, S8, S7, B36, S4, S3, B60, BT, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.954, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1074" upshifts 2334124 /Source="Nicolas_upshifts" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="upshifts" CDS 2334189..2334644 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17555270, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative indole acetic acid N-acetyltransferase" /protein_id="NP_390711.1" /db_xref="EnsemblGenomes-Gn:BSU28330" /db_xref="EnsemblGenomes-Tr:CAB14793" /db_xref="GOA:P94562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YX0" /db_xref="SubtiList:BG12336" /db_xref="UniProtKB/Swiss-Prot:P94562" /translation="MHIKIDDLTGRQVVSLVNEHLHSMTLMSPPESIHALGLEKLRGP EITFWSAWEGDELAGCGALKELDTRHGEIKSMRTSASHLRKGVAKQVLQHIIEEAEKR GYERLSLETGSMASFEPARKLYESFGFQYCEPFADYGEDPNSVFMTKKL*" /label="ysnE CDS" gene 2334189..2334644 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /label="ysnE gene" promotor_-35 2334752..2334758 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2334772..2334790 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2334779 /Source="Nicolas_upshifts" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="upshifts" CDS 2334828..2335649 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 27464829; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative stress response protein" /protein_id="NP_390712.3" /db_xref="EnsemblGenomes-Gn:BSU28340" /db_xref="EnsemblGenomes-Tr:CAB14794" /db_xref="InterPro:IPR019060" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG12337" /db_xref="UniProtKB/Swiss-Prot:P94560" /translation="MKSIVGVYETPQETIAAIEGLLTKGYDSDDISVVTSRRDTDYLE SRTGTEVNQAIDAHQDESESFFDKLKDYFTMDDTATHSKALSDLDIKTDEIDKYQEDL DDGKLLVAVDTDADVIAPIDNGNALSGGFSSTNELDYTTKEEKTMPLREEQLKVDKED VQTGEVEIGKEVKTEKRDMDIPVRHDEIYVERRPVDENKTDAAPVNDSEEIRVPIVEE KLEVTKKPVVTDEVVVGKRTVEENEHISETVKKEEPRLNKEGKVDGLDDDPLNNK*" /label="ysnF CDS" gene 2334828..2335649 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /label="ysnF gene" downshifts 2335642 /Source="Nicolas_upshifts" /id="D1448" /incds=0 /nref=8 /ntot=77 /MaxReadThrough="2.49244" /MaxDrop="8.12771" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts 2335706 /Source="Nicolas_upshifts" /id="D1449" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="1.26489" /MaxDrop="4.30778" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin=43 /isTUend="FALSE" /label="downshifts" tRNA complement(2335713..2335786) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg (UCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg2 tRNA" gene complement(2335713..2335786) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /label="trnSL-Arg2 gene" downshifts complement(2335747) /Source="Nicolas_upshifts" /id="D1450" /incds=0 /nref=34 /ntot=243 /MaxReadThrough="1.54905" /MaxDrop="4.72186" /score="24.0242272" /energy="-13.3" /TU="U2195,U2196" /idTUdmin="U2195" /TUdmin="-31" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2335823..2335842) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2335826) /Source="Nicolas_upshifts" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2335856..2335863) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2335917..2336426) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /EC_number="3.1.4.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390713.2" /db_xref="EnsemblGenomes-Gn:BSU28350" /db_xref="EnsemblGenomes-Tr:CAB14795" /db_xref="GOA:P94559" /db_xref="InterPro:IPR000979" /db_xref="InterPro:IPR020935" /db_xref="InterPro:IPR024654" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12334" /db_xref="UniProtKB/Swiss-Prot:P94559" /translation="MNVLIISDSHGLEEELQTIAKRHEAEVDLMIHCGDSELETRHPA LEPYAVVKGNCDFAGDFKDELLLTAGSRKILVTHGHLHGIKQTLLNVYYRAEELGADV ICFGHSHIAGSEVLRGKLMINPGSIRLPRVRRTESYAILTLENDAATVRFYDQAGNEI EDLQNRVTL*" /label="ysnB CDS" gene complement(2335917..2336426) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /label="ysnB gene" downshifts complement(2335934) /Source="Nicolas_upshifts" /id="D1451" /incds=0 /nref=87 /ntot=225 /MaxReadThrough="4.15666" /MaxDrop="5.59323" /score="24.0242272" /energy="-13.3" /TU="U2196,U2197" /idTUdmin="U2197" /TUdmin="-130" /isTUend="FALSE" /label="downshifts" CDS complement(2336442..2337038) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /EC_number="3.6.1.66" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16322510, 17090528, 17976651, 18689515, 19943897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyinosine/deoxyxanthosine triphosphate pyrophosphatase, promiscuous (subunit A)" /protein_id="NP_390714.1" /db_xref="EnsemblGenomes-Gn:BSU28360" /db_xref="EnsemblGenomes-Tr:CAB14796" /db_xref="GOA:P94558" /db_xref="InterPro:IPR002637" /db_xref="InterPro:IPR020922" /db_xref="InterPro:IPR029001" /db_xref="SubtiList:BG12333" /db_xref="UniProtKB/Swiss-Prot:P94558" /translation="MIIMKEAIIATHNPGKVKEFKEILEPRGYDVKSLAEIGFTEEIE ETGHTFEENAIMKAEAVAKAVNKMVIADDSGLSIDNLGGRPGVYSARYAGEQKDDQAN IEKVLSELKGIEKEQRTARFRCALAVSIPGEETKTVEGHVEGYIAEEPRGEYGFGYDP IFIVKDKDKTMAELTSDEKNKISHRADALKKLSKLLEA*" /label="rdgB CDS" gene complement(2336442..2337038) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /label="rdgB gene" CDS complement(2337051..2337788) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /EC_number="2.7.7.56" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1624460, 19153445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624460, 19153445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease PH" /protein_id="NP_390715.1" /db_xref="EnsemblGenomes-Gn:BSU28370" /db_xref="EnsemblGenomes-Tr:CAB14797" /db_xref="GOA:P28619" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR002381" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR018336" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="PDB:1OYP" /db_xref="PDB:1OYR" /db_xref="PDB:1OYS" /db_xref="SubtiList:BG10357" /db_xref="UniProtKB/Swiss-Prot:P28619" /translation="MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICNASVE DRVPPFLRGGGKGWITAEYSMLPRATNQRTIRESSKGKISGRTMEIQRLIGRALRAVV DLEKLGERTIWIDCDVIQADGGTRTASITGAFLAMAIAIGKLIKAGTIKTNPITDFLA AISVGIDKEQGILLDLNYEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNGL LGLAEKGIQELIDKQKEVLGDSLPELK*" /label="rph CDS" gene complement(2337051..2337788) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /label="rph gene" promotor_-10 complement(2337870..2337889) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2337886) /Source="Nicolas_upshifts" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2337899..2338999) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14662349, 27381174" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14662349, 27381174; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination (cortex hydrolysis) and sporulation (stage II, multiple polar septa) lytic enzyme" /protein_id="NP_390716.1" /db_xref="EnsemblGenomes-Gn:BSU28380" /db_xref="EnsemblGenomes-Tr:CAB14798" /db_xref="GOA:P39072" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10356" /db_xref="UniProtKB/Swiss-Prot:P39072" /translation="MLKKGPAVIGATCLTSALLLSGCGLFQSDKAAEEIDPPQDVTFV NDEAGANSNTTAAKKTESEKSDTAKADQASSTVMRELYLIDKNGYVVAQTLPLPKSES TAKQALEYLVQGGPVSEILPNGFRAVLPADTTVNVDIKKDGTAIADFSNEFKNYKKED EQKIVQSVTWTLTQFSSIDKVKLRINGHELKEMPVGGTPISDDLSRKDGINLETAGVN DLTATHPLTVYYLAENEDSEYYVPVTKRIDNSEKDDITAAINELAKGPSKVSGLLTDF SEDVKLVSKPKIKDGRVTLDFNQSIFGSADEKTKMISSEVLNSIVLTLTEQPDVKSVS VKVNGKSELVNEKGEKLTEPVSRPSQVNTGSF*" /label="gerM CDS" gene complement(2337899..2338999) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /label="gerM gene" promotor_-35 complement(2337904..2337909) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2337916) /Source="Nicolas_upshifts" /id="D1452" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="5.80816" /MaxDrop="4.3535" /score="41.5916163" /energy="-13" /TU="U2197" /idTUdmin="U2198" /TUdmin=1209 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2339022..2339040) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2339038) /Source="Nicolas_upshifts" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2339055..2339060) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2339114..2339932) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /EC_number="5.1.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15347750, 17610893, 17720142, 19309142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390717.2" /db_xref="EnsemblGenomes-Gn:BSU28390" /db_xref="EnsemblGenomes-Tr:CAB14799" /db_xref="GOA:P94556" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="PDB:1ZUW" /db_xref="SubtiList:BG11964" /db_xref="UniProtKB/Swiss-Prot:P94556" /translation="MLEQPIGVIDSGVGGLTVAKEIMRQLPKENIIYVGDTKRCPYGP RPEEEVLQYTWELTNYLLENHHIKMLVIACNTATAIALDDIQRSVGIPVVGVIQPGAR AAIKVTDNQHIGVIGTENTIKSNAYEEALLALNPDLKVENLACPLLVPFVESGKFLDK TADEIVKTSLYPLKDTSIDSLILGCTHYPILKEAIQRYMGEHVNIISSGDETAREVST ILSYKGLLNQSPIAPDHQFLTTGARDQFAKIADDWFGHEVGHVECISLQEPIKR*" /label="rcmE CDS" gene complement(2339114..2339932) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /label="rcmE gene" downshifts complement(2339126) /Source="Nicolas_upshifts" /id="D1453" /incds=0 /nref=230 /ntot=265 /MaxReadThrough="0.9265" /MaxDrop="6.72492" /score="41.5916163" /energy="-13" /TU="NA" /idTUdmin="U2198" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2339940..2340380) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26577401; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (mother cell's gene expression during sporulation)" /protein_id="NP_390718.1" /db_xref="EnsemblGenomes-Gn:BSU28400" /db_xref="EnsemblGenomes-Tr:CAB14800" /db_xref="GOA:P97247" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12332" /db_xref="UniProtKB/Swiss-Prot:P97247" /translation="MTSKPLEHVADIEKSLRHIAAIIKQKGREILNQYAITPPQFVGL QWLYELGDMTIGELSGKMYLACSTTTDLIDRMQKNELVERVKDPADRRVVRIHLLPEG ERIIQEVITKRQEYLRDMFESFTDEEIAIFEKSLMKLQHEMKRK*" /label="ysmB CDS" gene complement(2339940..2340380) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /label="ysmB gene" promotor_-10 complement(2340423..2340442) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2340432) /Source="Nicolas_upshifts" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2340434..2340576) /Source="Nicolas_S_feature" /locus_tag="new_2904537_2904679_c" /HighExp="BT, B36, S6, S8, S7, B60, Pyr, G/S, Lbtran, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.121047" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1075" promotor_-35 complement(2340458..2340462) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2340621) /Source="Nicolas_upshifts" /id="D1454" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="6.16749" /MaxDrop="4.6532" /score="20.9204638" /energy="-10.8" /TU="U2200,U2202" /idTUdmin="U2202" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" CDS complement(2340624..2340848) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transcriptional regulator required for the expression of late spore coat genes" /protein_id="NP_390719.2" /db_xref="EnsemblGenomes-Gn:BSU28410" /db_xref="EnsemblGenomes-Tr:CAB14801" /db_xref="GOA:P11470" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1FSE" /db_xref="SubtiList:BG10355" /db_xref="UniProtKB/Swiss-Prot:P11470" /translation="MKEKEFQSKPLLTKREREVFELLVQDKTTKEIASELFISEKTVR NHISNAMQKLGVKGRSQAVVELLRMGELEL*" /label="gerE CDS" gene complement(2340624..2340848) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /label="gerE gene" upshifts 2340897 /Source="Nicolas_upshifts" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2340899..2340917 /Source="Nicolas_upshift_promotors" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2340906..2340925) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2340926) /Source="Nicolas_upshifts" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2340939..2340948) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2340964..2341407) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390720.1" /db_xref="EnsemblGenomes-Gn:BSU28420" /db_xref="EnsemblGenomes-Tr:CAB14802" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10354" /db_xref="UniProtKB/Swiss-Prot:P11469" /translation="MKLPAYIDMPFQEWKTSFSFFNKVSVRFSETDMFGHMNNVTPFI YFEEVRISYFKKLNMMSENKQTMTVVASQQCDYLRQVMPYEELRIYVKTSAVGSSSLT LHYLGENLEGEPCFTGAVVMVQVSKESGKAVSWTDEEKETLLHTR*" /label="ysmA CDS" gene complement(2340964..2341407) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /label="ysmA gene" CDS complement(2341468..2342229) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 22720735, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 22720735, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (iron-sulfur protein)" /protein_id="NP_390721.1" /db_xref="EnsemblGenomes-Gn:BSU28430" /db_xref="EnsemblGenomes-Tr:CAB14803" /db_xref="GOA:P08066" /db_xref="InterPro:IPR004489" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR025192" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG10353" /db_xref="UniProtKB/Swiss-Prot:P08066" /translation="MSEQKTIRFIITRQDTADSTPYDEEFEIPYRPNLNVISALMEIR RNPVNVKGEKTTPVTWDMNCLEEVCGACSMVINGKPRQSCTALIDQLEQPIRLKPMKT FPVVRDLQVDRSRMFDSLKKVKAWIPIDGTYDLGPGPRMPEKRRQWAYELSKCMTCGV CLEACPNVNSKSKFMGPAPMSQVRLFNAHPTGAMNKSERLEALMDEGGLADCGNSQNC VQSCPKGIPLTTSIAALNRDTNLQAFRNFFGSDRV*" /label="sdhB CDS" gene complement(2341468..2342229) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /label="sdhB gene" downshifts complement(2341476) /Source="Nicolas_upshifts" /id="D1455" /incds=0 /nref=61 /ntot=257 /MaxReadThrough="5.46426" /MaxDrop="4.6864" /score="20.9204638" /energy="-10.8" /TU="U2202" /idTUdmin="U2205" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2342232..2343992) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 18535631, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 18535631, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (flavoprotein subunit)" /protein_id="NP_390722.2" /db_xref="EnsemblGenomes-Gn:BSU28440" /db_xref="EnsemblGenomes-Tr:CAB14804" /db_xref="GOA:P08065" /db_xref="InterPro:IPR003952" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR011280" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10352" /db_xref="UniProtKB/Swiss-Prot:P08065" /translation="MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVC AQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVM FNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF LGAVLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAAS IVYQQGAYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKY PAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKELDIKLGGIIEIYEK FMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSL LSAIYGGMVAGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYV LHKELGEWMTANVTVVRHNDKLLKTDDKIQELMERFKKININDTTKWSNQGAMFTRQF SNMLQLARVITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAPEFEYQD VDVSLITPRKRDYSKKKVAK*" /label="sdhA CDS" gene complement(2342232..2343992) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /label="sdhA gene" CDS complement(2344026..2344634) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /EC_number="1.3.5.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (cytochrome b558 subunit)" /protein_id="NP_390723.1" /db_xref="EnsemblGenomes-Gn:BSU28450" /db_xref="EnsemblGenomes-Tr:CAB14805" /db_xref="GOA:P08064" /db_xref="InterPro:IPR000701" /db_xref="InterPro:IPR011138" /db_xref="InterPro:IPR016002" /db_xref="InterPro:IPR034804" /db_xref="SubtiList:BG10351" /db_xref="UniProtKB/Swiss-Prot:P08064" /translation="MSGNREFYFRRLHSLLGVIPVGIFLIQHLVVNQFAARGAEAFNS AAHFMDSLPFRYALEIFIIFLPLIYHAVYGVYIAFTAKNNAGQYSYMRNWLFVLQRVT GIITLIFVSWHVWETRIAAQMGAEVNFDMMANILSSPAMLGFYIVGVLSTIFHFSNGL WSFAVTWGITVTPRSQRISTYVTLIIFVALSYVGLKAIFAFV*" /label="sdhC CDS" gene complement(2344026..2344634) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /label="sdhC gene" promotor_-35 2344404..2344411 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2344424..2344443 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2344426 /Source="Nicolas_upshifts" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2344635..2344730) /Source="Nicolas_S_feature" /locus_tag="new_2908738_2908833_c" /HighExp="Lbtran, dia5, Mt0, T0.30H, T1.0H, M0t90, M40t90, T0.0H, Glucon, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.78844099999999995" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1076" promotor_-10 complement(2344720..2344739) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-10" upshifts complement(2344730) /Source="Nicolas_upshifts" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="upshifts" S_feature complement(2344732..2345353) /Source="Nicolas_S_feature" /locus_tag="new_2908835_2909456_c" /HighExp="MG 120, B36, UNK1, Fru, MG 150, BMM, Gly, Glucon, Glu, GM-0.1" /AntisenseName="yslB" /AntisenseCor="-0.44143968421748903" /AntisenseRegPval="-13.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1077" promotor_-35 complement(2344754..2344761) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-35" promotor_-35 2344869..2344873 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2344883..2344983 /Source="Nicolas_upshift_promotors" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2344890..2344909 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2344899 /Source="Nicolas_upshifts" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" CDS 2344927..2345373 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390724.1" /db_xref="EnsemblGenomes-Gn:BSU28460" /db_xref="EnsemblGenomes-Tr:CAB14806" /db_xref="InterPro:IPR019642" /db_xref="InterPro:IPR024096" /db_xref="PDB:3NJC" /db_xref="SubtiList:BG11236" /db_xref="UniProtKB/Swiss-Prot:P42955" /translation="MKSKFEASIDNLKEIEMNAYAYELIREIVLPDMLGQDYSSMMYW AGKHLARKFPLESWEEFPAFFEEAGWGTLTNVSAKKQELEFELEGPIISNRLKHQKEP CFQLEAGFIAEQIQLMNDQIAESYEQVKKRADKVVLTVKWDMKDPV*" /label="yslB CDS" gene 2344927..2345373 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /label="yslB gene" upshifts 2344943 /Source="Nicolas_upshifts" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" downshifts 2345361 /Source="Nicolas_upshifts" /id="D1456" /incds=0 /nref=217 /ntot=255 /MaxReadThrough="2.21897" /MaxDrop="6.5759" /score="4.74486914" /energy="-10.8" /TU="NA" /idTUdmin="U2203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2345399) /Source="Nicolas_upshifts" /id="D1457" /incds=0 /nref=8 /ntot=160 /MaxReadThrough="5.89867" /MaxDrop="4.19639" /score="2.38159916" /energy="-10.8" /TU="U2205" /idTUdmin="U2206" /TUdmin=1270 /isTUend="FALSE" /label="downshifts" CDS complement(2345417..2346643) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2981221, 2981222, 14597663, 1980002, 8757727, 9851048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2981221, 2981222, 14597663, 1980002, 8757727, 9851048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II alpha subunit (aa 1->408)" /protein_id="NP_390725.1" /db_xref="EnsemblGenomes-Gn:BSU28470" /db_xref="EnsemblGenomes-Tr:CAB14807" /db_xref="GOA:P08495" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10350" /db_xref="UniProtKB/Swiss-Prot:P08495" /translation="MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMG KSTDELVSLAKAISDQPSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGI RTEAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVAL AAALKADKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEF AKNYQVPLEVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTL STIFTTLAKRNINVDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIET ESKLAKVSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAV ESLHDAFELSKHPSAV*" /label="lysCA CDS" CDS complement(2345417..2345908) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1980002, 2981221, 2981222, 8757727, 9851048, 14597663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1980002, 2981221, 2981222, 8757727, 9851048, 14597663; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II beta subunit (aa 246->408)" /protein_id="YP_009513994.1" /translation="MEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNIN VDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSG MVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLHDAFELSKHP SAV*" /label="lysCB CDS" gene complement(2345417..2346643) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /label="lysCA gene" gene complement(2345417..2345908) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /label="lysCB gene" downshifts complement(2346757) /Source="Nicolas_upshifts" /id="D1458" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="7.23315" /MaxDrop="4.15833" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=44 /isTUend="FALSE" /label="downshifts" misc_RNA complement(2346769..2346948) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:14523230, 14597663, 14627808, 21169337, 22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523230, 14597663, 14627808, 21169337, 22416067; Product type n: RNA" /label="kswC RNA" gene complement(2346769..2346948) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /label="kswC gene" downshifts complement(2346801) /Source="Nicolas_upshifts" /id="D1459" /incds=0 /nref=22 /ntot=132 /MaxReadThrough="7.09997" /MaxDrop="4.61976" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2346973..2346992) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-10" upshifts complement(2346980) /Source="Nicolas_upshifts" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="upshifts" promotor_-35 complement(2347005..2347012) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-35" CDS complement(2347013..2348785) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /EC_number="4.1.99.3" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8655545, 16267290, 16426634, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655545, 16267290, 16426634, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit C)" /protein_id="NP_390727.2" /db_xref="EnsemblGenomes-Gn:BSU28490" /db_xref="EnsemblGenomes-Tr:CAB14809" /db_xref="GOA:P14951" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR001162" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004791" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR035901" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10349" /db_xref="UniProtKB/Swiss-Prot:P14951" /translation="MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSY FTGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMNLIKKHDPKYNVMLKDDKTYPFI KLTHERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCL YYHLGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERA KELRDQIAHIESTMEKQKMTMNDLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSM FPLYQEADEEFLTFIGQFYSKNNHFLPKEILVPDSIDQSMIEQLLETNVHQPKKGPKK ELLMLAHKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGT NPVSAMIVFIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLI IIDGGKGQINAARDVIENELGLDIPIAGLAKDEKHRTSNLLIGDPLEVAYLERNSQEF YLLQRIQDEVHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSVKKMKEA SLEDIKKAGVPAAAAQLLYDKLQK*" /label="uvrC CDS" gene complement(2347013..2348785) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /label="uvrC gene" promotor_-10 complement(2348812..2348831) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-10" upshifts complement(2348826) /Source="Nicolas_upshifts" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="upshifts" promotor_-35 complement(2348845..2348852) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-35" downshifts complement(2348915) /Source="Nicolas_upshifts" /id="D1460" /incds=0 /nref=237 /ntot=268 /MaxReadThrough="4.77689" /MaxDrop="6.41061" /score="23.4086154" /energy="-10.5" /TU="U2207,U2208" /idTUdmin="U2209" /TUdmin=373 /isTUend="FALSE" /label="downshifts" CDS complement(2348921..2349235) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268; Product type c: carrier" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="NP_390728.1" /db_xref="EnsemblGenomes-Gn:BSU28500" /db_xref="EnsemblGenomes-Tr:CAB14810" /db_xref="GOA:P14949" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:2GZY" /db_xref="PDB:2GZZ" /db_xref="PDB:2IPA" /db_xref="PDB:2VOC" /db_xref="SubtiList:BG10348" /db_xref="UniProtKB/Swiss-Prot:P14949" /translation="MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQ EMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALQELVNK HL*" /label="trxA CDS" gene complement(2348921..2349235) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /label="trxA gene" promotor_-10 complement(2349261..2349280) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2349275) /Source="Nicolas_upshifts" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2349277..2349486) /Source="Nicolas_S_feature" /locus_tag="new_2913380_2913589_c" /HighExp="Etha, Salt, Gly, Sw, M9-stat, LPhT, BC, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984399999999996" /TUshortSig="SigB, SigA" /TUshortPSig="0.991, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1078" promotor_-35 complement(2349296..2349298) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2349380..2349490) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="CDS C-terminal fragment" /db_xref="PSEUDO:SOX90589.1" /translation="MVKYMTVKRRCDLMLRTILMIIGAIVVIGAIIRFVF*" /label="CDS C-terminal fragment" gene complement(2349380..2349490) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /pseudo /label="gene" promotor_-10 complement(2349476..2349494) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-10" upshifts complement(2349486) /Source="Nicolas_upshifts" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="upshifts" promotor_-35 complement(2349509..2349515) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-35" CDS complement(2349558..2351045) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 17827291, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 17827291, 18757805; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exo-alpha-L-arabinofuranosidase" /protein_id="NP_390729.2" /db_xref="EnsemblGenomes-Gn:BSU28510" /db_xref="EnsemblGenomes-Tr:CAB14811" /db_xref="GOA:P94552" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11985" /db_xref="UniProtKB/Swiss-Prot:P94552" /translation="MSEHQAVIQTDIAKGTINKNIYGHFAEHLGRGIYEGIWVGTDSD IPNINGIRKDVLEALKQLHIPVLRWPGGCFADEYHWANGVGDRKTMLNTHWGGTIESN EFGTHEFMMLCELLECEPYICGNVGSGTVQEMSEWIEYMTFEEGTPMSDWRKQNGREE PWKLKYFGVGNENWGCGGNMHPEYYADLYRRFQTYVRNYSGNDIYKIAGGANVDDFNW TDVLMKKAAGLMDGLSLHYYTIPGDFWKGKGSATEFTEDEWFITMKKAKYIDELIQKH GTIMDRYDPEQRVGLIIDEWGTWFDPEPGTNPGFLYQQNTIRDALVAASHFHIFHQHC RRVQMANIAQTVNVLQAMILTEGERMLLTPTYHVFNMFKVHQDASLLATETMSADYEW NGETLPQISISASKQAEGDINITICNIDHQNKAEAEIELRGLHKAADHSGVILTAEKM NAHNTFDDPHHVKPESFRQYTLSKNKLKVKLPPMSVVLLTLRADS*" /label="abfB CDS" gene complement(2349558..2351045) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /label="abfB gene" S_feature complement(2351046..2351158) /Source="Nicolas_S_feature" /locus_tag="new_2915149_2915261_c" /HighExp="T0.30H, M40t90, M0t90, BC, M9-stat, T1.30H, T1.0H, T2.0H, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1079" promotor_-10 complement(2351139..2351158) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-10" upshifts complement(2351158) /Source="Nicolas_upshifts" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="upshifts" promotor_-35 complement(2351173..2351180) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-35" CDS complement(2351262..2352239) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 20059546, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 20059546, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (alpha subunit)" /protein_id="NP_390730.1" /db_xref="EnsemblGenomes-Gn:BSU28520" /db_xref="EnsemblGenomes-Tr:CAB14812" /db_xref="GOA:P94551" /db_xref="InterPro:IPR001308" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR014731" /db_xref="InterPro:IPR018206" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR033947" /db_xref="SubtiList:BG11934" /db_xref="UniProtKB/Swiss-Prot:P94551" /translation="MGKKVIVLGEIRDGELRNVTFEAIAAGRTISGDGEVIGVLIGEN VQSIAQELIHYGADKVLTAEDPKLKTYTADGYSQVMRGVIEQENPDSVIFGHTAMGKD LSPKLAARLQTGLISDAIDVSVTGGNVVFTRPIYSGKAFERVISTDPMIFATIRPNNI QASEKDTSRSGSIESIDVSLTDLRTVIQEVVKKTADGVDLSEAKIIVAGGRGVKSKEG FQPLQELAEVLGAAVGASRGACDADYCDYALQIGQTGKVVTPDLYIACGISGAIQHLA GMSNSKVIVAINKDPEADIFKIADYGIVGDLFEVVPLLTEEFKQLNIHS*" /label="etfA CDS" gene complement(2351262..2352239) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /label="etfA gene" downshifts complement(2351270) /Source="Nicolas_upshifts" /id="D1461" /incds=0 /nref=58 /ntot=179 /MaxReadThrough="2.43782" /MaxDrop="7.95053" /score="30.2462458" /energy="-13.5" /TU="NA" /idTUdmin="U2210" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2352275..2353048) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10026281, 17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10026281, 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (beta subunit)" /protein_id="NP_390731.1" /db_xref="EnsemblGenomes-Gn:BSU28530" /db_xref="EnsemblGenomes-Tr:CAB14813" /db_xref="GOA:P94550" /db_xref="InterPro:IPR000049" /db_xref="InterPro:IPR012255" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR033948" /db_xref="SubtiList:BG11935" /db_xref="UniProtKB/Swiss-Prot:P94550" /translation="MNLFVLMKRTFDTEEKIVIETGKIQDDGAEWIINPYDEYAIEEA IQLKEKHGGTITAVTVGGEEAEKELRTALAMGCDQAVLINIEDDLDEPDQYSISQVLY HYMKDQEFDLILGGNVAIDGGSGQVAPRLAELLDIPCITTITKLEINGTDAEAERDVE GDVEKIKTTLPLLVTAQQGLNEPRYPSLPGIMKAKKKPLEELELDDLDLDEEDAEPKL KTIERFLPPKKEAGKLLQGEPAEQAKELVSLLRSEAKVI*" /label="etfB CDS" gene complement(2352275..2353048) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /label="etfB gene" CDS complement(2353063..2353839) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-CoA hydratase" /protein_id="NP_390732.1" /db_xref="EnsemblGenomes-Gn:BSU28540" /db_xref="EnsemblGenomes-Tr:CAB14814" /db_xref="GOA:P94549" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12331" /db_xref="UniProtKB/Swiss-Prot:P94549" /translation="MNAISLAVDQFVAVLTIHNPPANALSSRILEELSSCLDQCETDA GVRSIIIHGEGRFFSAGADIKEFTSLKGNEDSSLLAERGQQLMERIESFPKPIIAAIH GAALGGGLELAMACHIRIAAEDAKLGLPELNLGIIPGFAGTQRLPRYVGTAKALELIG SGEPISGKEALDLGLVSIGAKDEAEVIEKAKALAAKFAEKSPQTLASLLELLYSNKVY SYEGSLKLEAKRFGEAFESEDAKEGIQAFLEKRKPQFKGE*" /label="fadB CDS" gene complement(2353063..2353839) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /label="fadB gene" downshifts 2353128 /Source="Nicolas_upshifts" /id="D1462" /incds=1 /nref=1 /ntot=21 /MaxReadThrough="0.92259" /MaxDrop="4.42725" /score="-8.29305955" /energy="-5.1" /TU="NA" /idTUdmin="U2203" /TUdmin=7767 /isTUend="FALSE" /label="downshifts" CDS complement(2353854..2354438) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17189250, 18941141, 21398533, 24356978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 18941141, 21398533, 24356978; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of fatty acids degradation [FadR-long-chain (C14-C20) acyl-CoAs]" /protein_id="NP_390733.1" /db_xref="EnsemblGenomes-Gn:BSU28550" /db_xref="EnsemblGenomes-Tr:CAB14815" /db_xref="GOA:P94548" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013570" /db_xref="InterPro:IPR036271" /db_xref="PDB:1VI0" /db_xref="PDB:3WHB" /db_xref="PDB:3WHC" /db_xref="SubtiList:BG12330" /db_xref="UniProtKB/Swiss-Prot:P94548" /translation="MKQKRPKYMQIIDAAVEVIAENGYHQSQVSKIAKQAGVADGTIY LYFKNKEDILISLFKEKMGQFIERMEEDIKEKATAKEKLALVISKHFSLLAGDHNLAI VTQLELRQSNLELRQKINEILKGYLNILDGILTEGIQSGEIKEGLDVRLARQMIFGTI DETVTTWVMNDQKYDLVALSNSVLELLVSGIHNK*" /label="fadR CDS" gene complement(2353854..2354438) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /label="fadR gene" promotor_-10 complement(2354480..2354499) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2354480) /Source="Nicolas_upshifts" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2354512..2354519) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2354543..2356225) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17085570, 17189250, 21398533, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17085570, 17189250, 21398533, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long chain acyl-CoA ligase (degradative)" /protein_id="NP_390734.1" /db_xref="EnsemblGenomes-Gn:BSU28560" /db_xref="EnsemblGenomes-Tr:CAB14816" /db_xref="GOA:P94547" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG11946" /db_xref="UniProtKB/Swiss-Prot:P94547" /translation="MQSQKPWLAEYPNDIPHELPLPNKTLQSILTDSAARFPDKTAIS FYGKKLTFHDILTDALKLAAFLQCNGLQKGDRVAVMLPNCPQTVISYYGVLFAGGIVV QTNPLYTEHELEYQLRDAQVSVIITLDLLFPKAIKMKTLSIVDQILITSVKDYLPFPK NILYPLTQKQKVHIDFDKTANIHTFASCMKQEKTELLTIPKIDPEHDIAVLQYTGGTT GAPKGVMLTHQNILANTEMCAAWMYDVKEGAEKVLGIVPFFHVYGLTAVMNYSIKLGF EMILLPKFDPLETLKIIDKHKPTLFPGAPTIYIGLLHHPELQHYDLSSIKSCLSGSAA LPVEVKQKFEKVTGGKLVEGYGLSEASPVTHANFIWGKNKPGSIGCPWPSTDAAIYSE ETGELAAPYEHGEIIVKGPQVMKGYWNKPEETAAVLRDGWLFTGDMGYMDEEGFFYIA DRKKDIIIAGGYNIYPREVEEALYEHEAIQEIVVAGVPDSYRGETVKAFVVLKKGAKA DTEELDAFARSRLAPYKVPKAYEFRKELPKTAVGKILRRRLLEEETENHHIK*" /label="lcfA CDS" gene complement(2354543..2356225) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /label="lcfA gene" misc_feature complement(2356254..2356273) /Source="Nicolas_upshift_promotors" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2356262) /Source="Nicolas_upshifts" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2356350) /Source="Nicolas_upshifts" /id="D1463" /incds=0 /nref=8 /ntot=101 /MaxReadThrough="2.17789" /MaxDrop="3.3655" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2356414..2356818) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390735.1" /db_xref="EnsemblGenomes-Gn:BSU28570" /db_xref="EnsemblGenomes-Tr:CAB14817" /db_xref="GOA:P94546" /db_xref="InterPro:IPR007140" /db_xref="SubtiList:BG12329" /db_xref="UniProtKB/Swiss-Prot:P94546" /translation="MSDFWENELVEIAAYYSVAVLCLVLFLTVFELVTAYKNWEEIQK GNLAVAMATGGKILGIANVFQHSISQHNSLLQMIGWGVYGFVMLLISYFIFEFLTPRF KIDQEIENDNRAVGFISFVISVGLSFVVAAGI*" /label="yshE CDS" gene complement(2356414..2356818) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /label="yshE gene" downshifts complement(2356416) /Source="Nicolas_upshifts" /id="D1464" /incds=0 /nref=1 /ntot=75 /MaxReadThrough="3.74343" /MaxDrop="2.92029" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2356833..2359190) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11254128, 12719520, 22333191, 27799325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254128, 12719520, 22333191, 27799325; Product type f: factor" /codon_start=1 /transl_table=11 /product="homologous recombination factor" /protein_id="NP_390736.1" /db_xref="EnsemblGenomes-Gn:BSU28580" /db_xref="EnsemblGenomes-Tr:CAB14818" /db_xref="GOA:P94545" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR002625" /db_xref="InterPro:IPR005747" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036063" /db_xref="InterPro:IPR036187" /db_xref="SubtiList:BG12328" /db_xref="UniProtKB/Swiss-Prot:P94545" /translation="MQQKVLSALEFHKVKEQVIGHAASSLGKEMLLELKPSASIDEIK KQLDEVDEASDIIRLRGQAPFGGLVDIRGALRRAEIGSVLSPSEFTEISGLLYAVKQM KHFITQMAEDGVDIPLIHQHAEQLITLSDLERDINSCIDDHGEVLDHASETLRGIRTQ LRTLESRVRDRLESMLRSSSASKMLSDTIVTIRNDRFVIPVKQEYRSSYGGIVHDTSS SGATLFIEPQAIVDMNNSLQQAKVKEKQEIERILRVLTEKTAEYTEELFLDLQVLQTL DFIFAKARYAKAVKATKPIMNDTGFIRLKKARHPLLPPDQVVANDIELGRDFSTIVIT GPNTGGKTVTLKTLGLLTLMAQSGLHIPADEGSEAAVFEHVFADIGDEQSIEQSLSTF SSHMVNIVGILEQVNENSLVLFDELGAGTDPQEGAALAMSILDDVHRTNARVLATTHY PELKAYGYNREGVMNASVEFDIETLSPTYKLLIGVPGRSNAFEISKRLGLPDHIIGQA KSEMTAEHNEVDTMIASLEQSKKRAEEELSETESIRKEAEKLHKELQQQIIELNSKKD KMLEEAEQQAAEKVKAAMKEAEDIIHELRTIKEEHKSFKDHELINAKKRLEGAMPAFE KSKKPEKPKTQKRDFKPGDEVKVLTFGQKGTLLEKTGGNEWNVQIGILKMKVKEKDLE FIKSAPEPKKEKMITAVKGKDYHVSLELDLRGERYENALSRVEKYLDDAVLAGYPRVS IIHGKGTGALRKGVQDLLKNHRSVKSSRFGEAGEGGSGVTVVELK*" /label="mutSB CDS" gene complement(2356833..2359190) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /label="mutSB gene" CDS complement(2359211..2360923) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /EC_number="2.7.7.7" /EC_number="3.1.11.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:18776221, 18938175, 28254425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18776221, 18938175, 28254425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase/3'-5' exonuclease X" /protein_id="NP_390737.1" /db_xref="EnsemblGenomes-Gn:BSU28590" /db_xref="EnsemblGenomes-Tr:CAB14819" /db_xref="GOA:P94544" /db_xref="InterPro:IPR002054" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010996" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR022311" /db_xref="InterPro:IPR027421" /db_xref="InterPro:IPR029398" /db_xref="InterPro:IPR037160" /db_xref="SubtiList:BG12327" /db_xref="UniProtKB/Swiss-Prot:P94544" /translation="MHKKDIIRLLETIAVYMELKGDNPFKVSAFRKAAAALEQDDRSL SEMDDMMSLSGIGKGTYSVIKEYIDEGKSSTLESLQKEVPEGLVPLLKLPGLGGKKIA KLYKELGVHDAESLKEACEQQKVQGLAGFGKKSEEKILQALGEAGKQPERFPIGYALR IAREIEEHLSQFTHIIKFSRAGSLRRARETVKDLDYIIATDHPAEVREQLLELPNIKS VIASGDTKVSVILSFEYETSVDFRLVTEEQFPTTLHHFTGSKDHNIKMRQIAKERGER ISEYGVETVETGEIKTFPSEREFYAHFGLPLIPPEIRESGQEVETYSDSIELIELGQI KGDLHMHSTWSDGAFSIREMAEACIKKGYQYMAITDHSQYLKVANGLTAERLKQQAKE IDALNAEFENFRILKGVEMDILPDGTLDYDDDVLAEMDIVIASIHSSFNQPEHVIMKR LETALTNKHVDIIAHPTGRLIGRRAGYEIDIDQLIELARKTNTALELNANPARLDLRT EHLMKANEQGVTLVINTDAHNIEMLDDMKTGVTAARKGWTETKNVLNARSLKDVEAFL KRND*" /label="polX CDS" gene complement(2359211..2360923) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /label="polX gene" S_feature complement(2360924..2360996) /Source="Nicolas_S_feature" /locus_tag="new_2925027_2925099_c" /HighExp="Cold, LPhT, LBGstat, H2O2, dia15, G180, G135, Sw, G150, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1080" CDS complement(2360997..2361530) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390738.1" /db_xref="EnsemblGenomes-Gn:BSU28600" /db_xref="EnsemblGenomes-Tr:CAB14820" /db_xref="GOA:P94543" /db_xref="InterPro:IPR003825" /db_xref="SubtiList:BG12326" /db_xref="UniProtKB/Swiss-Prot:P94543" /translation="MLDIIILILLLMGTLLGLKRGFILQFIRLTSFILSIAFAALFYK NVAPHLHWIPAPDFSAGQPALSFFTGNLEAAYYNAIAFIVLFIIAKILLRIIGSFLSI VAGIPVIKQINQMLGAVLGFLEVYLFTFVLLYVASVLPVDALQQMMGQSSLANVIINH TPYLSGLLQELWTQYGA*" /label="yshB CDS" gene complement(2360997..2361530) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /label="yshB gene" CDS complement(2361537..2361794) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /experiment="publication(s) with functional evidences, PMID:15317782, 16796675, 18588879, 20711458, 24097947, 26258635" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317782, 16796675, 18588879, 20711458, 24097947, 26258635; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of cell division" /protein_id="NP_390739.1" /db_xref="EnsemblGenomes-Gn:BSU28610" /db_xref="EnsemblGenomes-Tr:CAB14821" /db_xref="GOA:P94542" /db_xref="InterPro:IPR007838" /db_xref="InterPro:IPR023688" /db_xref="InterPro:IPR036192" /db_xref="SubtiList:BG12325" /db_xref="UniProtKB/Swiss-Prot:P94542" /translation="MSDGKKTKTTVDIYGQHFTIVGEESRAHMRYVAGIVDDKMREIN EKNPYLDINKLAVLTAVNVVHDYVKLQEKCEKLERQLKEKD*" /label="zapA CDS" gene complement(2361537..2361794) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /label="zapA gene" promotor_-10 complement(2361821..2361840) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2361837) /Source="Nicolas_upshifts" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2361852..2361859) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2361877..2361896 /Source="Nicolas_upshift_promotors" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2361884 /Source="Nicolas_upshifts" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="upshifts" CDS 2361928..2362869 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /EC_number="3.1.26.4" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9888800, 10094689, 12794188, 23882084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888800, 10094689, 12794188, 23882084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HIII" /protein_id="NP_390740.1" /db_xref="EnsemblGenomes-Gn:BSU28620" /db_xref="EnsemblGenomes-Tr:CAB14822" /db_xref="GOA:P94541" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR004641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR024568" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12324" /db_xref="UniProtKB/Swiss-Prot:P94541" /translation="MSHSVIKVSLSAIDQMKMTYSGSLTASVPQGAVFQAKPPGCTIT AYQSGKVLFQGKNAAAESARWGTAEPQEKKKTAKKPADPRYAPPADIAGMSVIGSDEV GTGDYFGPMTVVCAYVDKTMLPLMKELGVKDSKDLKDPQIIEIARNLIKTIPYSLLVL KNEKYNSMQEKGMSQGKMKALLHNQAITHLLRKLDGVKPEAILIDQFAEPGVYFNHLK GRDIVKERTYFSTKAEGIHLAVAAASIIARYSFLMEMDKLSRAAGMTLPKGAGPHVDE AAAKLILKKGASALRTFTKLHFANTQKAQRLADKKRS*" /label="rnhC CDS" gene 2361928..2362869 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /label="rnhC gene" promotor_-10 complement(2362601..2362620) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2362616) /Source="Nicolas_upshifts" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2362634..2362641) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2362852 /Source="Nicolas_upshifts" /id="D1465" /incds=0 /nref=150 /ntot=232 /MaxReadThrough="1.71535" /MaxDrop="5.25365" /score="25.6336933" /energy="-13.7" /TU="NA" /idTUdmin="U2213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2362884) /Source="Nicolas_upshifts" /id="D1466" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.4685" /MaxDrop="5.29665" /score="-4.45611985" /energy="-14.9" /TU="NA" /idTUdmin="U2216" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(2362905..2365319) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (beta subunit)" /protein_id="NP_390741.1" /db_xref="EnsemblGenomes-Gn:BSU28630" /db_xref="EnsemblGenomes-Tr:CAB14823" /db_xref="GOA:P17922" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004532" /db_xref="InterPro:IPR005121" /db_xref="InterPro:IPR005146" /db_xref="InterPro:IPR005147" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020825" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR036690" /db_xref="SubtiList:BG10875" /db_xref="UniProtKB/Swiss-Prot:P17922" /translation="MFVSYKWLEDYVDLKGMDPAVLAEKITRAGIEVEGIEYKGEGIK GVVIGHVLEREQHPNADKLNKCLVDIGAEAPVQIICGAPNVDKGQKVAVATVGAVLPG NFKIKKAKLRGEESNGMICSLQELGIESKLVAKEYAEGIFVFPNDAETGSDALAALQL DDAILELGLTPNRADAMNMLGVAYEVAAILDTEVKLPQTDYPAASEQASDYISVKIED QEANPLYTAKIIKNVTIAPSPLWMQTKLMNAGIRPHNNVVDITNFVLLEYGQPLHAFD YDRFGSKEVVVRKAAENEMIVTLDDQERKLSADHLVITNGTKAQAVAGVMGGAESEVQ EDTKTILLEAAYFNGQKVRKASKDLGLRSESSVRFEKGIDPARVRLAAERAAQLIHLY AGGEVLAGTVEEDHLTIEANNIHVSADKVSSVLGLTISKEELISIYKRLGFTVGEADD LLVVTVPSRRGDITIEEDLIEEAARLYGYDNIPSTLPETAGTTGGLTPYQAKRRKVRR FLEGAGLSQAITYSLTNEKKATAFAIEKSLNTVLALPMSEERSILRHSLVPNLLDSVS YNLARQTDSVALYEVGSVFLTKEEDTKPVETERVAGAVTGLWRKQLWQGEKKPVDFFV VKGIVEGLLDKLNVLDSIEFVQSERKQLHPGRTANILLNGSLIGFIGQVHPSLEKELD IKETYVFELDLHALLAAETAPLVYTAIPKYPSVTRDIALVTDKTVTSGQLESVIKEAG GKLLKEVTVFDVYEGEHMEEGKKSVAFSLQYVNPEQTLTEEEVTKAHSKVLKALEDTY QAVLRG*" /label="pheT CDS" gene complement(2362905..2365319) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /label="pheT gene" downshifts complement(2362928) /Source="Nicolas_upshifts" /id="D1467" /incds=0 /nref=214 /ntot=255 /MaxReadThrough="3.98669" /MaxDrop="7.11892" /score="32.4736491" /energy="-14.7" /TU="NA" /idTUdmin="U2216" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2365335..2366369) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390742.1" /db_xref="EnsemblGenomes-Gn:BSU28640" /db_xref="EnsemblGenomes-Tr:CAB14824" /db_xref="GOA:P17921" /db_xref="InterPro:IPR002319" /db_xref="InterPro:IPR004188" /db_xref="InterPro:IPR004529" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR022911" /db_xref="SubtiList:BG10874" /db_xref="UniProtKB/Swiss-Prot:P17921" /translation="MEEKLKQLEQEALEQVEAASSLKVVNDIRVQYLGKKGPITEVLR GMGKLSAEERPKMGALANEVRERIANAIADKNEKLEEEEMKQKLAGQTIDVTLPGNPV AVGGRHPLTVVIEEIEDLFIGMGYTVEEGPEVETDYYNFESLNLPKEHPARDMQDSFY ITEETLMRTQTSPVQTRTMEKHEGKGPVKIICPGKVYRRDNDDATHSHQFMQIEGLVV DKNISMSDLKGTLELVAKKMFGQDREIRLRPSFFPFTEPSVEVDVTCFKCGGNGCSVC KGTGWIEILGAGMVHPNVLKMAGFDPKEYQGFAFGMGVERIAMLKYGIDDIRHFYTND VRFISQFKQA*" /label="pheS CDS" gene complement(2365335..2366369) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /label="pheS gene" S_feature complement(2366370..2366690) /Source="Nicolas_S_feature" /locus_tag="new_2930473_2930793_c" /HighExp="HPh, Cold, GM 15, GM 10, Sw, C30, G150, MG-0.2, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1081" CDS 2366451..2366657 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513995.1" /translation="MWPRYHPYFRQTDAVVSFIDITESDSGSPLRAVYAVPATTQEVK PISGCVKNALSQRHFLPGKQLIRN*" /label="hypothetical protein CDS" gene 2366451..2366657 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /label="gene" S_feature 2366680..2366944 /Source="Nicolas_S_feature" /locus_tag="new_2930783_2931047" /HighExp="S8, S7, S6, BT, C30, B36, S5, Pyr, C90, Glucon" /AntisenseName="ysgA" /AntisenseCor="-0.23049778674462801" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.519" /TUlongSig="NA" /TUlongPSig="NA" /label="S1082" upshifts 2366680 /Source="Nicolas_upshifts" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2366685..2366704) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2366687..2366701 /Source="Nicolas_upshift_promotors" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2366690) /Source="Nicolas_upshifts" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2366719..2366722) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2366724..2367470) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 24809820, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal RNA methylase" /protein_id="NP_390743.1" /db_xref="EnsemblGenomes-Gn:BSU28650" /db_xref="EnsemblGenomes-Tr:CAB14825" /db_xref="GOA:P94538" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG12323" /db_xref="UniProtKB/Swiss-Prot:P94538" /translation="MKQIESAKNQKVKDWKKLHTKKERTKTNTFLIEGEHLVEEALKS PGIVKEILVKDETRIPSDLETGIQCYMLSEDAFSAVTETETPQQIAAVCHMPEEKLAT ARKVLLIDAVQDPGNLGTMIRTADAAGLDAVVLGDGTADAFNGKTLRSAQGSHFHIPV VRRNLPSYVDELKAEGVKVYGTALQNGAPYQEIPQSESFALIVGNEGAGVDAALLEKT DLNLYVPLYGQAESLNVAVAAAILVYHLRG*" /label="rlmBB CDS" gene complement(2366724..2367470) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /label="rlmBB gene" promotor_-10 complement(2367497..2367516) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-10" promotor_-35 2367503..2367509 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2367510) /Source="Nicolas_upshifts" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="upshifts" promotor_-10 2367523..2367534 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2367530..2367536) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-35" upshifts 2367537 /Source="Nicolas_upshifts" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2367589..2367804 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8171126, 10806362, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8171126, 10806362, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_390744.1" /db_xref="EnsemblGenomes-Gn:BSU28660" /db_xref="EnsemblGenomes-Tr:CAB14826" /db_xref="GOA:P94537" /db_xref="InterPro:IPR017525" /db_xref="SubtiList:BG12318" /db_xref="UniProtKB/Swiss-Prot:P94537" /translation="MDLNLRHAVIANVTGNNQEQLEHTIVDAIQSGEEKMLPGLGVLF EVIWQHASESEKNEMLKTLEGGLKPAE*" /label="sspI CDS" gene 2367589..2367804 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /label="sspI gene" S_feature complement(2367786..2369198) /Source="Nicolas_S_feature" /locus_tag="new_2931889_2933301_c" /HighExp="S6, S8, S7, BT, S5, C30, B36, S4, B60, C90" /AntisenseName="ysfB" /AntisenseCor="0.46970634471519201" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1083" promotor_-35 2367815..2367822 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2367838..2367857 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2367846 /Source="Nicolas_upshifts" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2367873..2368979 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (glycolate degradation operon)" /protein_id="NP_390745.2" /db_xref="EnsemblGenomes-Gn:BSU28670" /db_xref="EnsemblGenomes-Tr:CAB14827" /db_xref="InterPro:IPR008599" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12319" /db_xref="UniProtKB/Swiss-Prot:P94536" /translation="MFLQPLLAKKIIAEVKKMYEREVIIVNTDGLIMAGTNDERVGQF HEGALICAKERRSVIITKEDETRLKGVKAGINLPVFFDHDVIAVFGLTGEPAEIQPFG ELLRKMTELFIKESRHLEQSQWRERMLESFMIDWLQLKEWSPSFLEKAQLLGVDLSSR RQMILIQGYEWSPHDIEQMARSWKSSYPADLFIRWGNERILINHEVPQHEQRDRLLRK ILHICSFANTASSQYTAAGAGRAVASSSLTDSYEQAEKALAVSLKRKTPIFEEDLKLD MCLTEISPGTRNEFPQRVLGKALEHQELMNTIRTFFHHDLSLKQTAEDMHIHINTLRY RLAKAEQLTGLRFDRTEDVVTMYVALYFLDQDTK*" /label="ysfB CDS" gene 2367873..2368979 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /label="ysfB gene" promotor_-35 2369015..2369018 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2369034..2369053 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2369038 /Source="Nicolas_upshifts" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="upshifts" CDS 2369082..2370494 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase subunit" /protein_id="NP_390746.1" /db_xref="EnsemblGenomes-Gn:BSU28680" /db_xref="EnsemblGenomes-Tr:CAB14828" /db_xref="GOA:P94535" /db_xref="InterPro:IPR004113" /db_xref="InterPro:IPR004490" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR016171" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12320" /db_xref="UniProtKB/Swiss-Prot:P94535" /translation="MITKDVKEQLIQVSGPENFDDSNAGRLVYSYDATPQYQSMPDAV IAPRNTDEISRILTICSEHRVPIVPRGSGTNLCGGTCPTEGGLVLLFKHMNQILEIDE ENLTATVQPGVITLDMIRAVESKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT RDYVIGLEVVLANGDIIRTGGKLAKDVAGYDLTRLFVGSEGTLGIVTEAIVKLVPKPE TKKTLLALYENIDAAAQTVSDIIAAKIIPATLEFLDQPTLLVIEDYAKIGLPTSAKAV LLIEQDGPFETVERDMEKIEAICKKGDAVSVQTAQTEEEAFALTEARRSALSALARLK PTTILEDATVPRSEIANMVKAINDIAAKYDISICTFGHAGDGNLHPTCTTDIRNKDEM ERVEQAFAEIFEKAIELGGTITGEHGVGEMKAPYLEMKLKKEGIDAMKALKAAFDPRN ILNPGKMFAKDARKRVVAER*" /label="glcD CDS" gene 2369082..2370494 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /label="glcD gene" promotor_-10 complement(2369184..2369203) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2369198) /Source="Nicolas_upshifts" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2369216..2369225) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2370491..2371825 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase (iron-sulfur subunit)" /protein_id="NP_390747.1" /db_xref="EnsemblGenomes-Gn:BSU28690" /db_xref="EnsemblGenomes-Tr:CAB14829" /db_xref="GOA:P94534" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012257" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="SubtiList:BG12321" /db_xref="UniProtKB/Swiss-Prot:P94534" /translation="MTTEKEMKQIQNEFKERMDEGELLNCMRCGFCLPSCPTYIESGF QETHSPRGRIALMKAVADGMIEPDEDVERSLSLCLGCRACEPVCPSGVKYGQLLEEAR DIIHQNKKHSLGERVMRKTAFHELFPHQNRMRSAVSLIGLYQRSGLQTAVRKSGMLRV LPEHLRTMEAVLPDVPKSKDMKHRPRFLPSIGPMKKRVAFFSGCLMDTMFLPTNNATL KLLQLAGCDIVIPPEQACCGALHGHSGEKNTGKELAKQNIAAFEALDVDAVITNAGGC GAFLTEYDHLLKDDPEWSERAAAFVQKLKDFSSVLVELDFHQMDLALETPQVVTYQDS CHLRNVMHTSLEPRQLLKSIKGAEFKEMEKADSCCGSAGIYNIVEVEMSMKILDSKMA AVKATEAILIVTANPGCLLQMKLGIEREGLSGKVRAVHLADLLLEAAGHKTS*" /label="glcF CDS" gene 2370491..2371825 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /label="glcF gene" Polymorphism join(2371524,2371526) /Source="geneious" /ID="SNP_BsDelta6_2935628_2935628" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=1035 /Change="C -> T" /Codon_Change="CTC -> CTT" /Coverage=142 /locus_tag="BSU_28690" /Protein_Effect="None" /Reference_Frequency="1.4%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=140 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2371823 /Source="Nicolas_upshifts" /id="D1468" /incds=0 /nref=48 /ntot=148 /MaxReadThrough="3.07756" /MaxDrop="5.25031" /score="4.55188138" /energy="-14.3" /TU="U2220" /idTUdmin="U2220" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" downshifts complement(2371862) /Source="Nicolas_upshifts" /id="D1469" /incds=0 /nref=27 /ntot=221 /MaxReadThrough="1.51397" /MaxDrop="5.34865" /score="-5.71907967" /energy="-14.3" /TU="NA" /idTUdmin="U2222" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2371864..2372106) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390748.1" /db_xref="EnsemblGenomes-Gn:BSU28700" /db_xref="EnsemblGenomes-Tr:CAB14830" /db_xref="InterPro:IPR025870" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12322" /db_xref="UniProtKB/Swiss-Prot:P94533" /translation="MALNTRESARDITALDIPDTSASNTFEIGFVTENVEAVIKRMRE QGVSIIGEPKVKPWGQTVAYIADPDGHYIEICSPME*" /label="ysfE CDS" gene complement(2371864..2372106) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /label="ysfE gene" S_feature complement(2372107..2372278) /Source="Nicolas_S_feature" /locus_tag="new_2936210_2936381_c" /HighExp="Sw, M0t90, M40t90, M9-stat, T2.0H, BC, T0.30H, Lbstat, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1084" CDS complement(2372166..2372336) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513996.1" /translation="MGADVERSELKDGSIYTGLEGLLKMLRGVGNESINEISYSIRIG QQAGYSFFTGIF*" /label="hypothetical protein CDS" gene complement(2372166..2372336) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /label="gene" CDS complement(2372279..2374075) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 1848300, 17320232, 19682248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 1848300, 17320232, 19682248; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="carbon starvation-induced membrane protein" /protein_id="NP_390749.2" /db_xref="EnsemblGenomes-Gn:BSU28710" /db_xref="EnsemblGenomes-Tr:CAB14831" /db_xref="GOA:P94532" /db_xref="InterPro:IPR003706" /db_xref="InterPro:IPR025299" /db_xref="SubtiList:BG11924" /db_xref="UniProtKB/Swiss-Prot:P94532" /translation="MNAVTIVIASMCILAIAYRLYGTFMMVKVLKVNDDKPTPAHALE DGKDYVPTNKWVSFGHHFAAIAAAGPLVGPILAAQFGYLPGLLWLLIGAVIGGAVHDI VVLFASMRKNGKSLSEVAKDELGPVAGFCTGLSMLFIITITMAGLSMVVLHALERNPW GTFAVGITIPIAMGVGLFYKKTGNLKLASTVGFLFLMAGVFIGPWVQTTALGDFLTLD TKTLAIALPVYAFFAAALPVWLLLAPRDYLSSFMKIGVFIALIVGVFVVNPSIPFPAF TEFVKGGGPVLAGPVWPFISITIACGAISGFHAFVGSGTTPKMLNKWSDMKPVAFGAM LVECLVGIMALIAATALQPADYFAINSTPEVFRTLGMNVVHLPELSGEIGLDLEGRTG GAVTLAVGMTYIFTGMPFFSHLASYFFQFVIMFEAVFILTAIDAGTRVARYLIQDFFG EVYKPLKKTDWIPGSVFASALACLMWGYLLYSGDIGSIWALFGVSNQLMASVGLIIGA TIVLKIADKRRYILTCLIPLAYLYVTVNYAGYWMVRNVYLNPEAAGYSVLNGVLSIIM LVLGFIIIVAAVKKWAQMWKDPSLRMEASIPG*" /label="cstA CDS" gene complement(2372279..2374075) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /label="cstA gene" promotor_-10 complement(2372381..2372399) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2372399) /Source="Nicolas_upshifts" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2372411..2372419) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2374072 /Source="Nicolas_upshifts" /id="D1470" /incds=0 /nref=4 /ntot=49 /MaxReadThrough="0.92122" /MaxDrop="3.18629" /score="12.2066828" /energy="-15.2" /TU="NA" /idTUdmin="U2220" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2374100..2374119) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2374110) /Source="Nicolas_upshifts" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2374134..2374140) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2374170..2374226) /Source="Nicolas_S_feature" /locus_tag="new_2938273_2938329_c" /HighExp="BC, Sw, M40t90, T1.30H, M0t90, T1.0H, T0.30H, Lbstat, T2.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1085" downshifts complement(2374194) /Source="Nicolas_upshifts" /id="D1471" /incds=0 /nref=12 /ntot=40 /MaxReadThrough="0.655710000000001" /MaxDrop="5.03461" /score="9.68754272" /energy="-10.5" /TU="NA" /idTUdmin="U2224" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2374227..2375729) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12777810, 14973026, 16233670, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12777810, 14973026, 16233670, 18757805; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-L-arabinofuranosidase" /protein_id="NP_390750.2" /db_xref="EnsemblGenomes-Gn:BSU28720" /db_xref="EnsemblGenomes-Tr:CAB14832" /db_xref="GOA:P94531" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11900" /db_xref="UniProtKB/Swiss-Prot:P94531" /translation="MKKARMIVDKEYKIGEVDKRIYGSFIEHMGRAVYEGIYEPDHPE ADEDGFRKDVQSLIKELQVPIIRYPGGNFLSGYNWEDGVGPVENRPRRLDLAWQTTET NEVGTNEFLSWAKKVNTEVNMAVNLGTRGIDAARNLVEYCNHPKGSYWSDLRRSHGYE QPYGIKTWCLGNEMDGPWQIGHKTADEYGRLAAETAKVMKWVDPSIELVACGSSNSGM PTFIDWEAKVLEHTYEHVDYISLHTYYGNRDNNLPNYLARSMDLDHFIKSVAATCDYV KAKTRSKKTINLSLDEWNVWYHSNEADKKVEPWITARPILEDIYNFEDALLVGSLLIT MLQHADRVKIACLAQLVNVIAPIMTEKGGEAWRQPIFYPYMHASVYGRGESLKPLISS PKYDCSDFTDVPYVDAAVVYSEEEETLTIFAVNKAEDQMETEISLRGFESYQIAEHIV LEHQDIKATNQHNRKNVVPHSNGSSSVSENGLTAHFTPLSWNVIRLKKQS*" /label="abfA CDS" gene complement(2374227..2375729) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /label="abfA gene" downshifts complement(2375600) /Source="Nicolas_upshifts" /id="D1472" /incds=1 /nref=7 /ntot=15 /MaxReadThrough="3.81491" /MaxDrop="6.33773" /score="2.73497974" /energy="-14.2" /TU="U2224,U2225" /idTUdmin="U2224" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(2375704..2375804) /Source="Nicolas_upshift_promotors" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2375744) /Source="Nicolas_upshifts" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2375748..2376593) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390751.2" /db_xref="EnsemblGenomes-Gn:BSU28730" /db_xref="EnsemblGenomes-Tr:CAB14833" /db_xref="GOA:P94530" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11912" /db_xref="UniProtKB/Swiss-Prot:P94530" /translation="MLRHSPQFSVYRIALTLFFMMLSLLYLFPIFCLLLGSLKPSSEL LRVGLNLDIDPKVMSFDNYTFLFNGGSIYFKWFFNSLVLGLFTTVLTLFFSSMIGYGL AVYDFKGRNIIFVLVLIIMMVPLEVMMLPLFKLTVGLHLIDSYTGVILPFIVSPVAVF FFRQYALGLPRDLLDSARMDGCTEFGIFFRIMAPLMKPAFGAMIILQSLNSWNNFLWP LIVLRSKEMFTLPIGLSSLLSPYGNNYDMLISGSVFAILPVIIIFLFFQKYFISGLTV GGVKG*" /label="araQ CDS" gene complement(2375748..2376593) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /label="araQ gene" CDS complement(2376594..2377535) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390752.1" /db_xref="EnsemblGenomes-Gn:BSU28740" /db_xref="EnsemblGenomes-Tr:CAB14834" /db_xref="GOA:P94529" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11911" /db_xref="UniProtKB/Swiss-Prot:P94529" /translation="MKPVKTGTVHPVPSAAKQSGWRDLFYSKKAAPYLFTAPFVLSFL VFFLYPIISVFIMSFQRILPGEVSFVGLSNYTALNNPTFYTALWNTLEYTFWTLIVLI PVPLLLAIFLNSKLVKFRNIFKSALFIPALTSTIVAGIIFRLIFGEMETSLANSILLK LGFSPQNWMNNEHTGMFLMVLLASWRWMGINILYFLAGLQNVPKELYEAADIDGANTM KKFLHITLPFLKPVTVYVLTISIIGGFRMFEESYVLWQNNSPGNIGLTLVGYLYQQGL AYNEMGYGAAIGIVLLIVILVVSLISLKLSGSFKGEG*" /label="araP CDS" gene complement(2376594..2377535) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /label="araP gene" CDS complement(2377571..2378872) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="sugar-binding lipoprotein" /protein_id="NP_390753.2" /db_xref="EnsemblGenomes-Gn:BSU28750" /db_xref="EnsemblGenomes-Tr:CAB14835" /db_xref="GOA:P94528" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG11910" /db_xref="UniProtKB/Swiss-Prot:P94528" /translation="MKKMTVCFLVLMMLLTLVIAGCSAEKSSGKSGETELTFWTFNGL HEQFYVEMVKEWNKKYPDRKIKLNTVVYPYGQMHDNLSISLIAGEGVPDIADVELARF SNFLKGSDIPLADLTPLIEKDRDKFVEARLTLYSKNGKLYGLDTHVGTTVMFYNMDVM KKAGVNPDDIKTWDDYHKAGQKVRKVTGKPMGTVETNDSATFLSMISQQNSGYFDKNG KLILNNDTNVKTLQYLKDMINDKTMIPAPGGGHHSEEYYGFMNQGGAASVLMPIWYMG RFIDYMPDLKGKIAIRPLPAWKEGGDRSAGLGGTATVVPKQSKHVELAKEFLAFAKGS EEGNKKLWSVLGFDPLRWDVWSSKELKEKNKYTDYFQNGTGIFSVLLDIKDEINPIYL HEDFAKASDLVNRSVLFDALKSQQKTPKQALDRAAGELKQK*" /label="araN CDS" gene complement(2377571..2378872) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /label="araN gene" CDS complement(2378903..2380087) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /EC_number="1.1.1.261" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-1-phosphate dehydrogenase [NAD+] (catabolic)" /protein_id="NP_390754.1" /db_xref="EnsemblGenomes-Gn:BSU28760" /db_xref="EnsemblGenomes-Tr:CAB14836" /db_xref="GOA:P94527" /db_xref="InterPro:IPR023003" /db_xref="InterPro:IPR032837" /db_xref="SubtiList:BG11909" /db_xref="UniProtKB/Swiss-Prot:P94527" /translation="MNRIAADVQRAFENAGEKTLPIKVEEIVLGKQAADSLLDYVKRK NNQHIVLVCDANTHRIAGIDLENRLNQEGFQAECLIIPENEAGDVTADERSLIHVLIH TKQPTDVMIAVGSGTIHDIVRFAAFQRDLPFISYPTAPSVDGFTSAGAPIILYGTKTT IQTKAPSALFADLDLLKAAPQSMVAAGFGDMLGKITSLADWEISRHLAGEPYSPAGAK IVQEALAACIEHTEDIAMKTETGIRVLMESLLVSGLVMLALDHSRPASGGEHHISHWI EMELMEKKRPQILHGAKVGCAAVLLTDTYRKLAQDDGLNEFSPSRREAIQSAYQTLPR GEVLADWLRSAGGPAYFDEIGVGQDSVKNAFRHAHTLRDRCTGLRIINENKTLINHGL YE*" /label="egsA CDS" gene complement(2378903..2380087) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /label="egsA gene" CDS complement(2380084..2380902) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /EC_number="3.1.3.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 14973026, 21575135, 22720735, 25848029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 14973026, 21575135, 22720735, 25848029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycolytic and pentose phosphate intermediates phosphatase" /protein_id="NP_390755.1" /db_xref="EnsemblGenomes-Gn:BSU28770" /db_xref="EnsemblGenomes-Tr:CAB14837" /db_xref="GOA:P94526" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11908" /db_xref="UniProtKB/Swiss-Prot:P94526" /translation="MRIMASHDTPVSPAGILIDLDGTVFRGNELIEGAREAIKTLRRM GKKIVFLSNRGNISRAMCRKKLLGAGIETDVNDIVLSSSVTAAFLKKHYRFSKVWVLG EQGLVDELRLAGVQNASEPKEADWLVISLHETLTYDDLNQAFQAAAGGARIIATNKDR SFPNEDGNAIDVAGMIGAIETSAQAKTELVVGKPSWLMAEAACTAMGLSAHECMIIGD SIESDIAMGKLYGMKSALVLTGSAKQGEQRLYTPDYVLDSIKDVTKLAEEGILI*" /label="araL CDS" gene complement(2380084..2380902) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /label="araL gene" CDS complement(2380880..2381569) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /EC_number="5.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10417639, 11418559, 11732895, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulose-5-phosphate 4-epimerase" /protein_id="NP_390756.1" /db_xref="EnsemblGenomes-Gn:BSU28780" /db_xref="EnsemblGenomes-Tr:CAB14838" /db_xref="GOA:P94525" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR004661" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG11906" /db_xref="UniProtKB/Swiss-Prot:P94525" /translation="MLETLKKEVLAANLKLQEHQLVTFTWGNVSGIDREKERIVIKPS GVEYSDLTADDLVVLNLDGEVVEGSLKPSSDTPTHVYLYKAFPNIGGIVHTHSQWATS WAQSGRDIPPLGTTHADYFDSAIPCTREMYDEEIIHDYELNTGKVIAETFQHHNYEQV PGVLVNNHGPFCWGTDALNAIHNAVVLETVAEMAYHSIMLNKDVTPINTVLHEKHFYR KHGANAYYGQS*" /label="araD CDS" gene complement(2380880..2381569) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /label="araD gene" CDS complement(2381586..2383268) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /EC_number="2.7.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 173711, 4910050, 10417639, 11418559, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulokinase" /protein_id="NP_390757.1" /db_xref="EnsemblGenomes-Gn:BSU28790" /db_xref="EnsemblGenomes-Tr:CAB14839" /db_xref="GOA:P94524" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005929" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG11905" /db_xref="UniProtKB/Swiss-Prot:P94524" /translation="MAYTIGVDFGTLSGRAVLVHVQTGEELAAAVKEYRHAVIDTVLP KTGQKLPRDWALQHPADYLEVLETTIPSLLEQTGVDPKDIIGIGIDFTACTILPIDSS GQPLCMLPEYEEEPHSYVKLWKHHAAQKHADRLNQIAEEEGEAFLQRYGGKISSEWMI PKVMQIAEEAPHIYEAADRIIEAADWIVYQLCGSLKRSNCTAGYKAMWSEKAGYPSDD FFEKLNPSMKTITKDKLSGSIHSVGEKAGSLTEKMAKLTGLLPGTAVAVANVDAHVSV PAVGITEPGKMLMIMGTSTCHVLLGEEVHIVPGMCGVVDNGILPGYAGYEAGQSCVGD HFDWFVKTCVPPAYQEEAKEKNIGVHELLSEKANHQAPGESGLLALDWWNGNRSTLVD ADLTGMLLGMTLLTKPEEIYRALVEATAYGTRMIIETFKESGVPIEELFAAGGIAEKN PFVMQIYADVTNMDIKISGSPQAPALGSAIFGALAAGKEKGGYDDIKKAAANMGKLKD ITYTPNAENAAVYEKLYAEYKELVHYFGKENHVMKRLKTIKNLQFSSAAKKN*" /label="araB CDS" gene complement(2381586..2383268) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /label="araB gene" CDS complement(2383282..2384772) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /EC_number="5.3.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 10669396, 11418559, 14973026, 18263741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 10669396, 11418559, 14973026, 18263741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-arabinose isomerase" /protein_id="NP_390758.2" /db_xref="EnsemblGenomes-Gn:BSU28800" /db_xref="EnsemblGenomes-Tr:CAB14840" /db_xref="GOA:P94523" /db_xref="InterPro:IPR003762" /db_xref="InterPro:IPR004216" /db_xref="InterPro:IPR009015" /db_xref="InterPro:IPR024664" /db_xref="SubtiList:BG11904" /db_xref="UniProtKB/Swiss-Prot:P94523" /translation="MLQTKDYEFWFVTGSQHLYGEETLELVDQHAKSICEGLSGISSR YKITHKPVVTSPETIRELLREAEYSETCAGIITWMHTFSPAKMWIEGLSSYQKPLMHL HTQYNRDIPWGTIDMDFMNSNQSAHGDREYGYINSRMGLSRKVIAGYWDDEEVKKEMS QWMDTAAALNESRHIKVARFGDNMRHVAVTDGDKVGAHIQFGWQVDGYGIGDLVEVMD RITDDEVDTLYAEYDRLYVISEETKRDEAKVASIKEQAKIELGLTAFLEQGGYTAFTT SFEVLHGMKQLPGLAVQRLMEKGYGFAGEGDWKTAALVRMMKIMAKGKRTSFMEDYTY HFEPGNEMILGSHMLEVCPTVALDQPKIEVHSLSIGGKEDPARLVFNGISGSAIQASI VDIGGRFRLVLNEVNGQEIEKDMPNLPVARVLWKPEPSLKTAAEAWILAGGAHHTCLS YELTAEQMLDWAEMAGIESVLISRDTTIHKLKHELKWNEALYRLQK*" /label="araA CDS" gene complement(2383282..2384772) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /label="araA gene" promotor_-10 complement(2384865..2384884) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2384872) /Source="Nicolas_upshifts" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2384874..2384949) /Source="Nicolas_S_feature" /locus_tag="new_2948977_2949052_c" /HighExp="M9-stat, T1.30H, T2.0H, T2.30H, T3.0H, T4.0H, T3.30H, T1.0H, BC, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1086" promotor_-35 complement(2384899..2384906) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2384950..2385921) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 15556708, 17827291, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 15556708, 17827291, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan-endo-1,5-alpha-L-arabinase" /protein_id="NP_390759.2" /db_xref="EnsemblGenomes-Gn:BSU28810" /db_xref="EnsemblGenomes-Tr:CAB14841" /db_xref="GOA:P94522" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR016840" /db_xref="InterPro:IPR023296" /db_xref="PDB:1UV4" /db_xref="SubtiList:BG11901" /db_xref="UniProtKB/Swiss-Prot:P94522" /translation="MKKKKTWKRFLHFSSAALAAGLIFTSAAPAEAAFWGASNELLHD PTMIKEGSSWYALGTGLTEERGLRVLKSSDAKNWTVQKSIFTTPLSWWSNYVPNYGQN QWAPDIQYYNGKYWLYYSVSSFGSNTSAIGLASSTSISSGGWKDEGLVIRSTSSNNYN AIDPELTFDKDGNPWLAFGSFWSGIKLTKLDKSTMKPTGSLYSIAARPNNGGALEAPT LTYQNGYYYLMVSFDKCCDGVNSTYKIAYGRSKSITGPYLDKSGKSMLEGGGTILDSG NDQWKGPGGQDIVNGNILVRHAYDANDNGIPKLLINDLNWSSGWPSY*" /label="abnA CDS" gene complement(2384950..2385921) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /label="abnA gene" S_feature complement(2385922..2386050) /Source="Nicolas_S_feature" /locus_tag="new_2950025_2950153_c" /HighExp="M9-stat, BC, T2.0H, T2.30H, T3.0H, S8, T1.30H, T3.30H, M0t90, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1087" promotor_-10 complement(2386035..2386054) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-10" upshifts complement(2386050) /Source="Nicolas_upshifts" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2386069..2386072) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-35" CDS complement(2386118..2387203) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15375159, 16021622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fructose-lysine aminopeptidase" /protein_id="NP_390760.1" /db_xref="EnsemblGenomes-Gn:BSU28820" /db_xref="EnsemblGenomes-Tr:CAB14842" /db_xref="GOA:P94521" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="PDB:1VHE" /db_xref="SubtiList:BG12317" /db_xref="UniProtKB/Swiss-Prot:P94521" /translation="MAKLDETLTMLKDLTDAKGIPGNEREVRQVMKSYIEPFADEVTT DRLGSLIAKKTGAENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTVGGWWAQVMLAQR VTIVTKKGEITGVIGSKPPHILSPEARKKSVEIKDMFIDIGASSREEALEWGVLPGDM IVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQNTDHPNIVYGVGTVQEEVGL RGAKTAAHTIQPDIAFGVDVGIAGDTPGISEKEAQSKMGKGPQIIVYDASMVSHKGLR DAVVATAEEAGIPYQFDAIAGGGTDSGAIHLTANGVPALSITIATRYIHTHAAMLHRD DYENAVKLITEVIKKLDRKTVDEITYQ*" /label="frvX CDS" gene complement(2386118..2387203) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /label="frvX gene" downshifts complement(2386132) /Source="Nicolas_upshifts" /id="D1473" /incds=0 /nref=233 /ntot=262 /MaxReadThrough="3.55686" /MaxDrop="6.91328" /score="-0.475558157" /energy="-9.9" /TU="U2227" /idTUdmin="U2227" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2387229..2387248) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-10" upshifts complement(2387252) /Source="Nicolas_upshifts" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2387263..2387270) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-35" promotor_-35 2387321..2387330 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2387336 /Source="Nicolas_upshifts" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2387342..2387357 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2387387..2387779 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10960106, 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390761.1" /db_xref="EnsemblGenomes-Gn:BSU28830" /db_xref="EnsemblGenomes-Tr:CAB14843" /db_xref="GOA:P94520" /db_xref="SubtiList:BG12316" /db_xref="UniProtKB/Swiss-Prot:P94520" /translation="MFVMVLRIILLALFAYCIYAVVKYVANPKRRLKLAQSKEHFYII DEQNNTRKNFQLTYKGVLFEGEKHIPSKDHPLFIHTIFVWTESPEKLKHFSAKDFENI EEKVLERYPNCKIDWDQPIKLAKKAEER*" /label="ysdB CDS" gene 2387387..2387779 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /label="ysdB gene" downshifts 2387750 /Source="Nicolas_upshifts" /id="D1474" /incds=0 /nref=86 /ntot=229 /MaxReadThrough="5.09744" /MaxDrop="4.57118" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-2112" /isTUend="FALSE" /label="downshifts" S_feature 2387795..2388101 /Source="Nicolas_S_feature" /locus_tag="new_2951898_2952204" /HighExp="Etha, M9-stat, T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, S8, T3.30H, Salt" /AntisenseName="ysdA" /AntisenseCor="-0.31305612685159701" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1088" CDS complement(2387795..2388064) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17289755; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_390762.1" /db_xref="EnsemblGenomes-Gn:BSU28840" /db_xref="EnsemblGenomes-Tr:CAB14844" /db_xref="GOA:P94519" /db_xref="InterPro:IPR010718" /db_xref="SubtiList:BG12315" /db_xref="UniProtKB/Swiss-Prot:P94519" /translation="MIIAAYLVLINLCGFWVMGIDKRKAQQHKWRISEDRLWLIAIVF GALGVWLGMQTFRHKTKHASFKYGVPLLLVIEAILIAIYYSPFDL*" /label="ysdA CDS" gene complement(2387795..2388064) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /label="ysdA gene" downshifts complement(2387811) /Source="Nicolas_upshifts" /id="D1475" /incds=0 /nref=6 /ntot=206 /MaxReadThrough="2.53274" /MaxDrop="3.80421" /score="20.1281719" /energy="-14" /TU="U2229" /idTUdmin="U2230" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" downshifts complement(2387980) /Source="Nicolas_upshifts" /id="D1476" /incds=1 /nref=1 /ntot=37 /MaxReadThrough="4.90568" /MaxDrop="2.19601" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2388058 /Source="Nicolas_upshifts" /id="D1477" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="4.08794" /MaxDrop="3.37039" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" CDS complement(2388121..2388480) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L20" /protein_id="NP_390763.1" /db_xref="EnsemblGenomes-Gn:BSU28850" /db_xref="EnsemblGenomes-Tr:CAB14845" /db_xref="GOA:P55873" /db_xref="InterPro:IPR005813" /db_xref="InterPro:IPR035566" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11971" /db_xref="UniProtKB/Swiss-Prot:P55873" /translation="MPRVKGGTVTRKRRKKVLKLAKGYFGSKHTLYKVANQQVMKSGN YAFRDRRQKKRDFRKLWITRINAAARMNGLSYSRLMHGLKLSGIEVNRKMLADLAVND LTAFNQLADAAKAQLNK*" /label="rplT CDS" gene complement(2388121..2388480) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /label="rplT gene" downshifts complement(2388134) /Source="Nicolas_upshifts" /id="D1478" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="5.94351" /MaxDrop="6.27682" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(2388512..2388712) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L35" /protein_id="NP_390764.1" /db_xref="EnsemblGenomes-Gn:BSU28860" /db_xref="EnsemblGenomes-Tr:CAB14846" /db_xref="GOA:P55874" /db_xref="InterPro:IPR001706" /db_xref="InterPro:IPR018265" /db_xref="InterPro:IPR021137" /db_xref="InterPro:IPR037229" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11972" /db_xref="UniProtKB/Swiss-Prot:P55874" /translation="MPKMKTHRGSAKRFKKTGSGKLKRSHAYTSHLFANKSQKQKRKL RKSAVVSAGDFKRIKQMLANIK*" /label="rpmI CDS" gene complement(2388512..2388712) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /label="rpmI gene" CDS complement(2388725..2389246) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-3" /protein_id="NP_390765.1" /db_xref="EnsemblGenomes-Gn:BSU28870" /db_xref="EnsemblGenomes-Tr:CAB14847" /db_xref="GOA:P55872" /db_xref="InterPro:IPR001288" /db_xref="InterPro:IPR019813" /db_xref="InterPro:IPR019814" /db_xref="InterPro:IPR019815" /db_xref="InterPro:IPR036787" /db_xref="InterPro:IPR036788" /db_xref="SubtiList:BG11944" /db_xref="UniProtKB/Swiss-Prot:P55872" /translation="MISKDQLVNEGIRAREVRLIGQNGDQLGIKSRQEALEIAGRANL DLVLVAANAKPPVCRIMDYGKFRFEQQKKEKEARKNQKIINLKEVRLSPTIDEHDFNT KLRNAIKFLEKGDKVKASIRFKGRAITHKEIGQRVLDRFSEACAEVATVETKPKMDGR SMFLMLAPKNEKQ*" /label="infC CDS" gene complement(2388725..2389246) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /label="infC gene" misc_RNA complement(2389308..2389447) /locus_tag="BSU_misc_RNA_47" /product="mRNA L20_leader attenuator sequence" /experiment="publication(s) with functional evidences, PMID:17289755, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17289755, 23611891" /label="mRNA L20 leader attenuator sequence" gene complement(2389308..2389447) /locus_tag="BSU_misc_RNA_47" /label="gene" promotor_-10 complement(2389444..2389463) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2389454) /Source="Nicolas_upshifts" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2389456..2389520) /Source="Nicolas_S_feature" /locus_tag="new_2953559_2953623_c" /HighExp="Paraq, G180, G150, G135, H2O2, LPh, C30, Oxctl, LBGexp, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1089" promotor_-35 complement(2389477..2389484) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2389502..2389521) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2389520) /Source="Nicolas_upshifts" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2389537..2389541) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2389639..2389646 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2389660..2389678 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2389660 /Source="Nicolas_upshifts" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="upshifts" CDS 2389692..2390357 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /function="14: Cell envelope" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390767.2" /db_xref="EnsemblGenomes-Gn:BSU28890" /db_xref="EnsemblGenomes-Tr:CAB14849" /db_xref="SubtiList:BG12314" /db_xref="UniProtKB/Swiss-Prot:P94517" /translation="MNKLIQLALFFTLMLTGCSNSSTSSESKVETTVKTTAAFPQKEL EKELKKLKPVSLDMKFESPLATELGKRKAKEEAEKQRQIAAEKKLEKEREAKRKKQQE EKAERQRLAEQQAAERQRLAEAERQAELERQRQAAIQKEQKANAEKKRQSQAQRQQTE APSSNSQDPPSSSSQTDKTIQQPASELPDDDGYGYEERKKWHDDQVEWGIKQGYIDPE DAP*" /label="yscB CDS" gene 2389692..2390357 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /label="yscB gene" downshifts 2390335 /Source="Nicolas_upshifts" /id="D1479" /incds=0 /nref=27 /ntot=178 /MaxReadThrough="2.51181" /MaxDrop="3.43861" /score="13.4996084" /energy="-15.8" /TU="NA" /idTUdmin="U2231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2390389..2391084) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /function="16.5: Explore" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pyruvate import system subunit B" /protein_id="NP_390768.1" /db_xref="EnsemblGenomes-Gn:BSU28900" /db_xref="EnsemblGenomes-Tr:CAB14850" /db_xref="GOA:P94516" /db_xref="InterPro:IPR007300" /db_xref="InterPro:IPR024891" /db_xref="SubtiList:BG12312" /db_xref="UniProtKB/Swiss-Prot:P94516" /translation="MESTMSPYFGIVVSLAAFGIGTFLFKKTKGFFLFTPLFVAMVLG IAFLKIGGFSYADYNNGGEIIKFFLEPATIAFAIPLYKQRDKLKKYWWQIMASIIAGS ICSVTIVYLLAKGIHLDSAVMKSMLPQAATTAIALPLSKGIGGISDITAFAVIFNAVI VYALGALFLKVFKVKNPISKGLALGTSGHALGVAVGIEMGEVEAAMASIAVVVVGVVT VLVIPVFVQLIGG*" /label="pftB CDS" gene complement(2390389..2391084) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /label="pftB gene" downshifts complement(2390411) /Source="Nicolas_upshifts" /id="D1480" /incds=0 /nref=19 /ntot=45 /MaxReadThrough="1.25312" /MaxDrop="6.13174" /score="49.3872074" /energy="-13.7" /TU="NA" /idTUdmin="U2232" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2390455) /Source="Nicolas_upshifts" /id="D1481" /incds=1 /nref=2 /ntot=36 /MaxReadThrough="6.79502" /MaxDrop="3.1016" /score="49.3872074" /energy="-13.7" /TU="U2232" /idTUdmin="U2232" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(2391106..2391546) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15659658, 17452642, 26060272, 27422364, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15659658, 17452642, 26060272, 27422364, 28974613; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyruvate uptake system subunit A" /protein_id="NP_390769.1" /db_xref="EnsemblGenomes-Gn:BSU28910" /db_xref="EnsemblGenomes-Tr:CAB14851" /db_xref="GOA:P94515" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023736" /db_xref="SubtiList:BG12311" /db_xref="UniProtKB/Swiss-Prot:P94515" /translation="MSAKKVYGFLTQAFIFAVIMLVSNMIAAIVPIPIPASVVGLVLL FLLLCLKVIKLEQVETLGTSLTSLIGFLFVPSGISVMNSLGVMQQYGLQIVLVILLAT IILLGATGLFSQLILSLSGKRKTEADMKTKTVQSPQNNNELVHH*" /label="pftA CDS" gene complement(2391106..2391546) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /label="pftA gene" promotor_-10 complement(2391568..2391587) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2391587) /Source="Nicolas_upshifts" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2391603..2391606) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2391680..2392405) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LytS]" /protein_id="NP_390770.1" /db_xref="EnsemblGenomes-Gn:BSU28920" /db_xref="EnsemblGenomes-Tr:CAB14852" /db_xref="GOA:P94514" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11953" /db_xref="UniProtKB/Swiss-Prot:P94514" /translation="MLRVLIVDDEMLARDELAYLLKRTNDEMEINEAENIESAFDQMM DQKPDLLFLDVDLSGENGFDIAKRLKKMKHPPAIVFATAYDQYALKAFEVDALDYLTK PFDEERIQQTLKKYKKVNRDIVETEQNSHAGQHKLALSVGESIVIVDTKDIIYAGTED GHVNVKTFDHSYTVSDTLVVIEKKLPDSDFIRVHRSFVVNTEYIKEIQPWFNSTYNLI MKDGSKIPVSRTYAKELKKLLHI*" /label="lytT CDS" gene complement(2391680..2392405) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /label="lytT gene" downshifts complement(2391709) /Source="Nicolas_upshifts" /id="D1482" /incds=0 /nref=231 /ntot=256 /MaxReadThrough="-0.0173499999999995" /MaxDrop="6.64673" /score="-8.47161605" /energy="-8.9" /TU="NA" /idTUdmin="U2232" /TUdmin="-1298" /isTUend="FALSE" /label="downshifts" CDS complement(2392383..2394164) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /function="16.3: Control" /function="16.13: Shape" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LytT]" /protein_id="NP_390771.1" /db_xref="EnsemblGenomes-Gn:BSU28930" /db_xref="EnsemblGenomes-Tr:CAB14853" /db_xref="GOA:P94513" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11952" /db_xref="UniProtKB/Swiss-Prot:P94513" /translation="MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAIL ISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVG AGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIG MESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARAL ETHRVLTIADQTLPFFRQGLNENSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMD HHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAIVLPLTSNGNTIGTL KMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFL FNAINTISALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQ ARFPGKYKIELNIDSRLEQIEIPPFVLQVLVENALRHAFPKKQDICKVTVCVLSDDAS VYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAALHISSEV HKGTEVSFQVPMQQMKEGEEHAQGVNS*" /label="lytS CDS" gene complement(2392383..2394164) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /label="lytS gene" promotor_-35 2394248..2394251 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2394260..2394279) /Source="Nicolas_upshift_promotors" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2394265) /Source="Nicolas_upshifts" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2394266..2394285 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2394273 /Source="Nicolas_upshifts" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2394331..2395113 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:15479782, 24123841, 25848029, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15479782, 24123841, 25848029, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase" /protein_id="NP_390772.2" /db_xref="EnsemblGenomes-Gn:BSU28940" /db_xref="EnsemblGenomes-Tr:CAB14854" /db_xref="GOA:P94512" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12310" /db_xref="UniProtKB/Swiss-Prot:P94512" /translation="MKAVFFDLDDTLLWDEKSVRTTFAETCLQAEKKYGLAPEEFEAA VREAARELYMSYETYPYTVMIGINPFEGLWSNFSEPISEGFQKLNKIVPEYRRNAWTN GLKALGIDDPAYGEYLGEFFAAERRKRPFVYDETFAVLDQLKGKYELLLLTNGDPSLQ KEKLAGVPELAPYFNEIVISGAFGKGKPDVSIFEHCLKLMNIEKDDAIMVGDNLNTDI LGASRAGIKTVWINRTDKKNETDVKPDYIISSLHDLFPILEK*" /label="ysaA CDS" gene 2394331..2395113 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /label="ysaA gene" downshifts 2395097 /Source="Nicolas_upshifts" /id="D1483" /incds=0 /nref=36 /ntot=265 /MaxReadThrough="1.0046" /MaxDrop="6.73727" /score="35.9560361" /energy="-13.8" /TU="NA" /idTUdmin="U2234" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" downshifts complement(2395147) /Source="Nicolas_upshifts" /id="D1484" /incds=0 /nref=89 /ntot=246 /MaxReadThrough="1.13716" /MaxDrop="6.01766" /score="35.534455" /energy="-13.8" /TU="NA" /idTUdmin="U2235" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2395154..2397085) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8692931, 9826762, 10632708, 15831787, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8692931, 9826762, 10632708, 15831787, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_390773.1" /db_xref="EnsemblGenomes-Gn:BSU28950" /db_xref="EnsemblGenomes-Tr:CAB14855" /db_xref="GOA:P18255" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10362" /db_xref="UniProtKB/Swiss-Prot:P18255" /translation="MSDMVKITFPDGAVKEFAKGTTTEDIAASISPGLKKKSLAGKLN GKEIDLRTPINEDGTVEIITEGSEEGLQIMRHSAAHLLAQAIKRIYKDVKFGVGPVIE NGFYYDVEMDEAITPEDLPKIEKEMKKIVNANLPIVRKEVSREEAKARFAEIGDDLKL ELLDAIPEGETVSIYEQGEFFDLCRGVHVPSTGKIKEFKLLSLAGAYWRGDSKNQMLQ RVYGTAFFKKADLEEHLRMLEEAKERDHRKLGKELKLFANSQKVGQGLPLWLPKGATI RRVIERYIVDKEISLGYEHVYTPVLGSKELYETSGHWDHYQEGMFPPMEMDNETLVLR PMNCPHHMMIYKQDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFV RPDQIKDEFIRTVRLIQDVYEDFGLSDYTFRLSYRDPEDTEKYFDDDEMWNKAQSMLK EAMDEIGHDYYEAEGEAAFYGPKLDVQVKTAIGKEETLSTVQLDFLLPERFDLTYIGE DGKQHRPVVIHRGVVSTMERFVAFLIEEHKGALPTWLAPVQFQVIPVSPAVHLDYAKK VQERLQCEGLRVEVDSRDEKIGYKIREAQMQKIPYMLVVGDQEAENGAVNVRKYGEQN SETISLDEFVKKAVAEAKK*" /label="thrS CDS" gene complement(2395154..2397085) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /label="thrS gene" misc_RNA complement(2397129..2397376) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:9098041, 9826762, 1317842, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 9826762, 1317842, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboT RNA" gene complement(2397129..2397376) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /label="tboT gene" promotor_-10 complement(2397132..2397141) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2397132) /Source="Nicolas_upshifts" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2397187) /Source="Nicolas_upshifts" /id="D1485" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="6.71261" /MaxDrop="3.31801" /score="19.160794" /energy="-16.2" /TU="U2236,U2237,U2238,U2241" /idTUdmin="U2239" /TUdmin=221 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2397387..2397406) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2397400) /Source="Nicolas_upshifts" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2397402..2397482) /Source="Nicolas_S_feature" /locus_tag="new_2961505_2961585_c" /HighExp="S3, S4, LoTm, S5, G135, G180, LBGtran, T5.0H, G/S, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1090" promotor_-35 complement(2397422..2397426) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2397483..2398328) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22882546; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation protein" /protein_id="NP_390774.2" /db_xref="EnsemblGenomes-Gn:BSU28960" /db_xref="EnsemblGenomes-Tr:CAB14856" /db_xref="InterPro:IPR014199" /db_xref="SubtiList:BG10361" /db_xref="UniProtKB/Swiss-Prot:P06569" /translation="MLEIIFEDDHDAAAFLHLIQHSDDRNNIIVREGIRKIGIEKANP AFPIQRFMEPILVKFFLECKEDEHMLSLIEETYCFTDQDEQQQILQLAHSIIEGEADD LPFEPLKLSRKQSILDELQTICLEEGVFYIRSFQTFRLGSYYKQLRDITEAAIDEYKM EQEYQNFIQTLRDYVDAKQPRIKKVHIVHDGSFTLWELRYVPEREKMKYIDRRFVRDH PMYIDSHLLAPLISIAPDEVVLYTDQPEHMMARTIQNVFQERVEMLPLHAFTDAEIPV KHSEG*" /label="ytxC CDS" gene complement(2397483..2398328) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /label="ytxC gene" promotor_-10 complement(2398348..2398366) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2398354) /Source="Nicolas_upshifts" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2398382..2398387) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2398407..2399048) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25728272, 27190159; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative osomosensing transporter" /protein_id="NP_390775.1" /db_xref="EnsemblGenomes-Gn:BSU28970" /db_xref="EnsemblGenomes-Tr:CAB14857" /db_xref="GOA:P06568" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG10360" /db_xref="UniProtKB/Swiss-Prot:P06568" /translation="MKRKTAVKWLAVLAGAGLLYWGNKTYLNVSPKEIRVWVLSFGVF APLMFIGISIVRPLVLFPVSVISIAGGLAFGPLLGTLYTLFGSMCASAVSFFAAGLFS AKKNGHYERLEAIQKQMEDNGFFYIFLLRILPINFDFVSYAAGLSNVKALPYFAATAV GIIPGTIALNVLGASFLAGNLPAFFMVLALYIVFISLPFIFRKKMQNLFQESN*" /label="ytxB CDS" gene complement(2398407..2399048) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /label="ytxB gene" CDS complement(2399082..2400017) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 17003052, 17289076, 19255093, 19968790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17003052, 17289076, 19255093, 19968790; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loader" /protein_id="NP_390776.1" /db_xref="EnsemblGenomes-Gn:BSU28980" /db_xref="EnsemblGenomes-Tr:CAB14858" /db_xref="GOA:P06567" /db_xref="InterPro:IPR002611" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009928" /db_xref="InterPro:IPR027417" /db_xref="PDB:2K7R" /db_xref="PDB:4M4W" /db_xref="SubtiList:BG10359" /db_xref="UniProtKB/Swiss-Prot:P06567" /translation="MEPIGRSLQGVTGRPDFQKRLEQMKEKVMKDQDVQAFLKENEEV IDQKMIEKSLNKLYEYIEQSKNCSYCSEDENCNNLLEGYHPKLVVNGRSIDIEYYECP VKRKLDQQKKQQSLMKSMYIQQDLLGATFQQVDISDPSRLAMFQHVTDFLKSYNETGK GKGLYLYGKFGVGKTFMLAAIANELAEKEYSSMIVYVPEFVRELKNSLQDQTLEEKLN MVKTTPVLMLDDIGAESMTSWVRDEVIGTVLQHRMSQQLPTFFSSNFSPDELKHHFTY SQRGEKEEVKAARLMERILYLAAPIRLDGENRRHP*" /label="dnaI CDS" gene complement(2399082..2400017) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /label="dnaI gene" CDS complement(2400045..2401463) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loading protein; replication initiationmembrane attachment protein" /protein_id="NP_390777.1" /db_xref="EnsemblGenomes-Gn:BSU28990" /db_xref="EnsemblGenomes-Tr:CAB14859" /db_xref="GOA:P07908" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="SubtiList:BG10358" /db_xref="UniProtKB/Swiss-Prot:P07908" /translation="MADYWKDVLPVDPYVVKSRSMLQDIDRQIITQLYQPLIGPVAFS LYMTLWGELEQNRLWGGESTHRQLMGMTQSNLKTIHQEQGKLEGIGLLKVYMKESERQ ERLFIYELLPPLRPNEFFEDGMLNVFLYNRVGKTKYQQLKQFFTHPAISEDAKDITRP FNHAFESLQPSEWKLTSDMEETVRLAEGSEYTSVGQSPSYTITEDVFDFDLFLAGLSE TMIPRKAMTQQVRDTIKKLSYLYGIDPLQMQNVVMSAIDERDVITTEALRKAASDWYQ IERNGQLPDLVEKTQPVHLREGEQPAEEDSLDGKLIALLEAISPKKLLQDIADGTEPS KADLKIIEEIMFEQKLEPGVTNVLIYYVMLKTDMKLSKNYIQKIASHWARKKVKTVRE AMKLAIEENRQYLEWAEGKTKSSKRNQKVIREEKLPDWMTEKETASDSESGQQKLHPQ DLEEQKKKMMEEMQKLKKYSAY*" /label="dnaB CDS" gene complement(2400045..2401463) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /label="dnaB gene" promotor_-10 complement(2401492..2401511) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2401500) /Source="Nicolas_upshifts" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2401526..2401529) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2401578..2402036) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16950922, 27920297, 28624879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950922, 27920297, 28624879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of transcription of ribonucleotide reductase nrd genes and operons" /protein_id="NP_390778.1" /db_xref="EnsemblGenomes-Gn:BSU29000" /db_xref="EnsemblGenomes-Tr:CAB14860" /db_xref="GOA:Q45549" /db_xref="InterPro:IPR003796" /db_xref="InterPro:IPR005144" /db_xref="SubtiList:BG13833" /db_xref="UniProtKB/Swiss-Prot:Q45549" /translation="MKCPSCQHNGTRVLDSRPVDDGKSIRRRRECESCHYRFTTFEKV EETPLIVVKKEGVREEFSREKMLRGLIKACEKRPVSLKTLEDMCFDIEKELRNQGCSE VKSELVGEMVMDRLAKIDEVAYVRFASVYRQFKDINVFIDELKDLIKKER*" /label="nrdR CDS" gene complement(2401578..2402036) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /label="nrdR gene" downshifts complement(2401597) /Source="Nicolas_upshifts" /id="D1486" /incds=0 /nref=14 /ntot=175 /MaxReadThrough="4.1553" /MaxDrop="3.90408" /score="12.4797073" /energy="-21.2" /TU="U2239,U2241" /idTUdmin="U2243" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2402037..2402184) /Source="Nicolas_S_feature" /locus_tag="new_2966140_2966287_c" /HighExp="dia5, dia15, Lbstat, Diami, Heat, M9-stat, M0t90, M40t90, LBGtran, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, SigA" /TUshortPSig="0.998, 0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1091" promotor_-10 complement(2402175..2402194) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-10" upshifts complement(2402184) /Source="Nicolas_upshifts" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="upshifts" S_feature complement(2402186..2402264) /Source="Nicolas_S_feature" /locus_tag="new_2966289_2966367_c" /HighExp="Lbstat, M40t90, Heat, M9-stat, M0t90, G180, S8, S5, T1.30H, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1092" promotor_-35 complement(2402209..2402212) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-35" downshifts complement(2402309) /Source="Nicolas_upshifts" /id="D1487" /incds=0 /nref=204 /ntot=262 /MaxReadThrough="5.70146" /MaxDrop="5.85416" /score="12.4797073" /energy="-21.2" /TU="U2241,U2242,U2243" /idTUdmin="U2242" /TUdmin="-237" /isTUend="FALSE" /label="downshifts" CDS complement(2402310..2402690) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /EC_number="4.1.1.50" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 10844697, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10844697, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine decarboxylase" /protein_id="NP_390779.2" /db_xref="EnsemblGenomes-Gn:BSU29010" /db_xref="EnsemblGenomes-Tr:CAB14861" /db_xref="GOA:O34426" /db_xref="InterPro:IPR003826" /db_xref="InterPro:IPR016067" /db_xref="InterPro:IPR017716" /db_xref="SubtiList:BG13832" /db_xref="UniProtKB/Swiss-Prot:O34426" /translation="METMGRHVISELWGCDFDKLNDMDFIEKTFVNAALKSGAEVREV AFHKFAPQGVSGVVIISESHLTIHSFPEHGYASIDVYTCGDLDPNVAADYIAEALHAD TRENIEIPRGMGPVQIKQAQAKVL*" /label="speD CDS" gene complement(2402310..2402690) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /label="speD gene" S_feature complement(2402691..2402845) /Source="Nicolas_S_feature" /locus_tag="new_2966794_2966948_c" /HighExp="Lbstat, M40t90, M9-stat, T2.0H, T3.0H, M0t90, T3.30H, Sw, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1093" promotor_-10 complement(2402825..2402844) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2402832 /Source="Nicolas_upshifts" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2402833..2402852 /Source="Nicolas_upshift_promotors" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2402845) /Source="Nicolas_upshifts" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2402859..2402865) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2402923..2402934) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2402929..2403951) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /EC_number="1.2.1.59" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NADP-dependent, gluconeogenesis)" /protein_id="NP_390780.1" /db_xref="EnsemblGenomes-Gn:BSU29020" /db_xref="EnsemblGenomes-Tr:CAB14862" /db_xref="GOA:O34425" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12592" /db_xref="UniProtKB/Swiss-Prot:O34425" /translation="MKVKVAINGFGRIGRMVFRKAMLDDQIQVVAINASYSAETLAHL IKYDTIHGRYDKEVVAGEDSLIVNGKKVLLLNSRDPKQLPWREYDIDIVVEATGKFNA KDKAMGHIEAGAKKVILTAPGKNEDVTIVMGVNEDQFDAERHVIISNASCTTNCLAPV VKVLDEEFGIESGLMTTVHAYTNDQKNIDNPHKDLRRARACGESIIPTTTGAAKALSL VLPHLKGKLHGLALRVPVPNVSLVDLVVDLKTDVTAEEVNEAFKRAAKTSMYGVLDYS DEPLVSTDYNTNPHSAVIDGLTTMVMEDRKVKVLAWYDNEWGYSCRVVDLIRHVAARM KHPSAV*" /label="gapB CDS" gene complement(2402929..2403951) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /label="gapB gene" upshifts complement(2402930) /Source="Nicolas_upshifts" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2402949..2402955) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2403995..2404014) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2404026) /Source="Nicolas_upshifts" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2404027..2404034) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2404157..2404537) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HxlR family)" /protein_id="NP_390781.1" /db_xref="EnsemblGenomes-Gn:BSU29030" /db_xref="EnsemblGenomes-Tr:CAB14863" /db_xref="GOA:O34533" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HZT" /db_xref="SubtiList:BG13831" /db_xref="UniProtKB/Swiss-Prot:O34533" /translation="MEKKKYNISVEATLEVIGGKWKCVILCHLTHGKKRTSELKRLMP NITQKMLTQQLRELEADGVINRIVYNQVPPKVEYELSEYGRSLEGILDMLCAWGANHI NRVYGDTFSVLEESVLNDKLKQES*" /label="ytcD CDS" gene complement(2404157..2404537) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /label="ytcD gene" downshifts complement(2404181) /Source="Nicolas_upshifts" /id="D1488" /incds=0 /nref=17 /ntot=164 /MaxReadThrough="1.55675" /MaxDrop="3.64816" /score="18.9828659" /energy="-15.3" /TU="NA" /idTUdmin="U2245" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(2404538..2404668) /Source="Nicolas_S_feature" /locus_tag="new_2968641_2968771_c" /HighExp="dia15, Diami, dia5, LBGstat, G180, Etha, S5, LBGtran, H2O2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1094" promotor_-35 2404593..2404597 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2404613..2404632 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2404614..2404720 /Source="Nicolas_S_feature" /locus_tag="new_2968717_2968823" /HighExp="Diami, G180, G135, LBGstat, G150, LBGexp, Paraq, Oxctl, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1095" upshifts 2404614 /Source="Nicolas_upshifts" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2404658..2404677) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2404668) /Source="Nicolas_upshifts" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2404692..2404699) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2404721..2405911 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390782.1" /db_xref="EnsemblGenomes-Gn:BSU29040" /db_xref="EnsemblGenomes-Tr:CAB14864" /db_xref="GOA:O34367" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13825" /db_xref="UniProtKB/Swiss-Prot:O34367" /translation="MTSANKSNIPALLALAVSAFAIGTTEFISVGLLPLIADDLDIPV TTAGLTVSLYALGVTFGAPILTSLTSSMSRKTLLLWIMFIFIAGNTMAATASSIGILL AARVISAFSHGVFMSIGSTIAADIVPEDKRASAISIMFTGLTVATVTGVPFGTFIGQQ FGWRFAFMVIIAVGIIAFITNGILVPSKLRKGTKTTMRDQLKLVTNSRLLLLFVITAL GYGGTFVVFTYLSPLLQEVTGFKAGTVAVILLGYGIAIAIGNMIGGKLSNRNPIAALF YMFIVQAIVLFVLTFTAPYQAAGLITILCMGLLAFMNVPGLQVYVVMLAERFVPSAVD VASAMNIAAFNAGIALGSYLGGVITDSIGLIHTAWIGGLMVVGAVILTGWSRLMEKRD RQEA*" /label="ytbD CDS" gene 2404721..2405911 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /label="ytbD gene" promotor_-10 complement(2405543..2405561) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2405559) /Source="Nicolas_upshifts" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2405577..2405582) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2405935..2406777 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /EC_number="1.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19585557, 20981419, 28032445, 28130301" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19585557, 20981419, 28032445, 28130301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aldo/keto reductase" /protein_id="NP_390783.1" /db_xref="EnsemblGenomes-Gn:BSU29050" /db_xref="EnsemblGenomes-Tr:CAB14865" /db_xref="GOA:O34678" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3B3D" /db_xref="SubtiList:BG13826" /db_xref="UniProtKB/Swiss-Prot:O34678" /translation="MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHG YRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSL SKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAE IKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSV AQIILRWDLQHGIITIPKSTKEHRIKENASVFDFELTQDDMNRIDALNENLRVGPDPD NFDF*" /label="ytbE CDS" gene 2405935..2406777 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /label="ytbE gene" promotor_-35 2406550..2406555 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2406571..2406589 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2406572 /Source="Nicolas_upshifts" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2406770 /Source="Nicolas_upshifts" /id="D1489" /incds=0 /nref=13 /ntot=124 /MaxReadThrough="1.16017" /MaxDrop="5.72508" /score="24.0721062" /energy="-11.4" /TU="NA" /idTUdmin="U2244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2406810) /Source="Nicolas_upshifts" /id="D1490" /incds=0 /nref=168 /ntot=263 /MaxReadThrough="3.38494" /MaxDrop="6.57333" /score="13.4291259" /energy="-11.4" /TU="NA" /idTUdmin="U2248" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2406819..2407412) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /EC_number="2.7.1.24" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 11886213, 12538896, 12682299, 15044829, 15526298, 17603993; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphocoenzyme A kinase" /protein_id="NP_390784.1" /db_xref="EnsemblGenomes-Gn:BSU29060" /db_xref="EnsemblGenomes-Tr:CAB14866" /db_xref="GOA:O34932" /db_xref="InterPro:IPR001977" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13824" /db_xref="UniProtKB/Swiss-Prot:O34932" /translation="MTLVIGLTGGIASGKSTVANMLIEKGITVIDADIIAKQAVEKGM PAYRQIIDEFGEDILLSNGDIDRKKLGALVFTNEQKRLALNAIVHPAVRQEMLNRRDE AVANREAFVVLDIPLLFESKLESLVDKIIVVSVTKELQLERLMKRNQLTEEEAVSRIR SQMPLEEKTARADQVIDNSGTLEETKRQLDEIMNSWA*" /label="coaE CDS" gene complement(2406819..2407412) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /label="coaE gene" CDS complement(2407428..2408060) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23396918; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane calmodulin-like protein essential for stage III sporulation" /protein_id="NP_390785.2" /db_xref="EnsemblGenomes-Gn:BSU29070" /db_xref="EnsemblGenomes-Tr:CAB14867" /db_xref="GOA:C0SP79" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR014205" /db_xref="SubtiList:BG13823" /db_xref="UniProtKB/Swiss-Prot:C0SP79" /translation="MQMVSILLLALAVSLDSFSVGFTYGLRKMKIPFKAILVIACCSG AVMFISMLIGSFLTKFFPVYVTEKLGGLILVGIGAWVLYQFFKPAKDKEYLLHEKTLL NLEVRSLGIVIHILRKPMSADIDKSGVINGIEAVLLGFALSIDAFGAGIGAAILGFSP IVMSIAVAIMSSLFVSIGINAGHFLSKWKWIDKMAFLPGLLLITIGLWKL*" /label="spcF CDS" gene complement(2407428..2408060) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /label="spcF gene" S_feature complement(2408061..2408225) /Source="Nicolas_S_feature" /locus_tag="new_2972164_2972328_c" /HighExp="LPhT, dia15, Sw, LBGtran, LBGstat, H2O2, Diami, G135, Lbstat, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1096" CDS complement(2408226..2409056) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /EC_number="3.2.2.23" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15109717, 25825434, 28517932; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formamidopyrimidine-DNA glycosylase; 5-hydroxymethyl-uracil DNA-glycosylase" /protein_id="NP_390786.2" /db_xref="EnsemblGenomes-Gn:BSU29080" /db_xref="EnsemblGenomes-Tr:CAB14868" /db_xref="GOA:O34403" /db_xref="InterPro:IPR000214" /db_xref="InterPro:IPR010663" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR012319" /db_xref="InterPro:IPR015886" /db_xref="InterPro:IPR015887" /db_xref="InterPro:IPR020629" /db_xref="InterPro:IPR035937" /db_xref="SubtiList:BG12628" /db_xref="UniProtKB/Swiss-Prot:O34403" /translation="MPELPEVETVRRTLTGLVKGKTIKSVEIRWPNIIKRPAEPEEFA RKLAGETIQSIGRRGKFLLFHLDHYVMVSHLRMEGKYGLHQAEEPDDKHVHVIFTMTD GTQLRYRDVRKFGTMHLFKPGEEAGELPLSQLGPEPDAEEFTSAYLKDRLAKTNRAVK TALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAEIKNTLQEAIDAG GSTVRSYINSQGEIGMFQLQHFVYGKKDEPCKNCGTMISKIVVGGRGTHFCAKCQTKK *" /label="mutM CDS" gene complement(2408226..2409056) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /label="mutM gene" CDS complement(2409079..2411721) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /EC_number="2.7.7.7" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3125407, 6777244, 9231429, 12081953, 17905985, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3125407, 6777244, 9231429, 12081953, 17905985, 27399782; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase I" /protein_id="NP_390787.1" /db_xref="EnsemblGenomes-Gn:BSU29090" /db_xref="EnsemblGenomes-Tr:CAB14869" /db_xref="GOA:O34996" /db_xref="InterPro:IPR001098" /db_xref="InterPro:IPR002298" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR002562" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR018320" /db_xref="InterPro:IPR019760" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12656" /db_xref="UniProtKB/Swiss-Prot:O34996" /translation="MTERKKLVLVDGNSLAYRAFFALPLLSNDKGVHTNAVYGFAMIL MKMLEDEKPTHMLVAFDAGKTTFRHGTFKEYKGGRQKTPPELSEQMPFIRELLDAYQI SRYELEQYEADDIIGTLAKSAEKDGFEVKVFSGDKDLTQLATDKTTVAITRKGITDVE FYTPEHVKEKYGLTPEQIIDMKGLMGDSSDNIPGVPGVGEKTAIKLLKQFDSVEKLLE SIDEVSGKKLKEKLEEFKDQALMSKELATIMTDAPIEVSVSGLEYQGFNREQVIAIFK DLGFNTLLERLGEDSAEAEQDQSLEDINVKTVTDVTSDILVSPSAFVVEQIGDNYHEE PILGFSIVNETGAYFIPKDIAVESEVFKEWVENDEQKKWVFDSKRAVVALRWQGIELK GAEFDTLLAAYIINPGNSYDDVASVAKDYGLHIVSSDESVYGKGAKRAVPSEDVLSEH LGRKALAIQSLREKLVQELENNDQLELFEELEMPLALILGEMESTGVKVDVDRLKRMG EELGAKLKEYEEKIHEIAGEPFNINSPKQLGVILFEKIGLPVVKKTKTGYSTSADVLE KLADKHDIVDYILQYRQIGKLQSTYIEGLLKVTRPDSHKVHTRFNQALTQTGRLSSTD PNLQNIPIRLEEGRKIRQAFVPSEKDWLIFAADYSQIELRVLAHISKDENLIEAFTND MDIHTKTAMDVFHVAKDEVTSAMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAGAFI DRYLESFQGVKAYMEDSVQEAKQKGYVTTLMHRRRYIPELTSRNFNIRSFAERTAMNT PIQGSAADIIKKAMIDMAAKLKEKQLKARLLLQVHDELIFEAPKEEIEILEKLVPEVM EHALALDVPLKVDFASGPSWYDAK*" /label="polA CDS" gene complement(2409079..2411721) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /label="polA gene" promotor_-10 complement(2411776..2411795) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2411785) /Source="Nicolas_upshifts" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2411809..2411816) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2411845..2411964) /Source="Nicolas_S_feature" /locus_tag="new_2975948_2976067_c" /HighExp="M0t90, M40t90, M9-stat, Lbstat, Sw, T1.30H, T1.0H, S4, S3, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1097" downshifts complement(2411888) /Source="Nicolas_upshifts" /id="D1491" /incds=0 /nref=48 /ntot=175 /MaxReadThrough="5.58383" /MaxDrop="3.85702" /score="15.0073484" /energy="-12.2" /TU="U2249" /idTUdmin="U2254" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2411965..2413704) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_390788.1" /db_xref="EnsemblGenomes-Gn:BSU29100" /db_xref="EnsemblGenomes-Tr:CAB14870" /db_xref="GOA:P23545" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR031967" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3CWF" /db_xref="SubtiList:BG10364" /db_xref="UniProtKB/Swiss-Prot:P23545" /translation="MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIE KEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKV QALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLC TAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSL AIDLMEMTRTQEMQRDRLLTVIENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLR RLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGI VLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLS IILKESERLQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISL HLNVPKDPQYVSGDPYRLKQVFLNLVNNALTYTPEGGSVAINVKPREKDIQIEVADSG IGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSELGRGTV FTVTLKRAAEKSA*" /label="phoR CDS" gene complement(2411965..2413704) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /label="phoR gene" CDS complement(2413697..2414419) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_390789.2" /db_xref="EnsemblGenomes-Gn:BSU29110" /db_xref="EnsemblGenomes-Tr:CAB14871" /db_xref="GOA:P13792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1MVO" /db_xref="SubtiList:BG10363" /db_xref="UniProtKB/Swiss-Prot:P13792" /translation="MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAET EKPDLIVLDVMLPKLDGIEVCKQLRQQKLMFPILMLTAKDEEFDKVLGLELGADDYMT KPFSPREVNARVKAILRRSEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQL ELTPKEFELLLYLGRHKGRVLTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTK KPIYIKTIRGLGYKLEEPKMNE*" /label="phoP CDS" gene complement(2413697..2414419) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /label="phoP gene" promotor_-10 complement(2414487..2414506) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2414497) /Source="Nicolas_upshifts" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2414499..2414599) /Source="Nicolas_S_feature" /locus_tag="new_2978602_2978702_c" /HighExp="M40t90, T1.30H, T1.0H, M0t90, M9-stat, T2.0H, T2.30H, T3.0H, T0.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1098" promotor_-35 complement(2414520..2414526) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2414631..2415569) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /EC_number="1.1.1.37" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate dehydrogenase (NAD-dependent)" /protein_id="NP_390790.1" /db_xref="EnsemblGenomes-Gn:BSU29120" /db_xref="EnsemblGenomes-Tr:CAB14872" /db_xref="GOA:P49814" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011275" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11386" /db_xref="UniProtKB/Swiss-Prot:P49814" /translation="MGNTRKKVSVIGAGFTGATTAFLIAQKELADVVLVDIPQLENPT KGKALDMLEASPVQGFDAKITGTSNYEDTAGSDIVVITAGIARKPGMSRDDLVSTNEK IMRSVTQEIVKYSPDSIIVVLTNPVDAMTYAVYKESGFPKERVIGQSGVLDTARFRTF VAEELNLSVKDVTGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERIDAIVERTRKGG GEIVNLLGNGSAYYAPAASLTEMVEAILKDQRRVLPTIAYLEGEYGYEGIYLGVPTIV GGNGLEQIIELELTDYERAQLNKSVESVKNVMKVLS*" /label="mdh CDS" gene complement(2414631..2415569) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /label="mdh gene" downshifts complement(2414644) /Source="Nicolas_upshifts" /id="D1492" /incds=0 /nref=200 /ntot=242 /MaxReadThrough="8.27126" /MaxDrop="7.40884" /score="-0.758981483" /energy="-13.5" /TU="U2251,U2254" /idTUdmin="U2250" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2415613..2416884) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /EC_number="1.1.1.42" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8045898, 9244258, 11290745, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045898, 9244258, 11290745, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isocitrate dehydrogenase" /protein_id="NP_390791.1" /db_xref="EnsemblGenomes-Gn:BSU29130" /db_xref="EnsemblGenomes-Tr:CAB14873" /db_xref="GOA:P39126" /db_xref="InterPro:IPR004439" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="PDB:1HQS" /db_xref="SubtiList:BG10856" /db_xref="UniProtKB/Swiss-Prot:P39126" /translation="MAQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEA AVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGI RSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGS EEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTL VHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAA GKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINY ETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVLLLEHLGWNEAADLVIKSMEKTIAS KVVTYDFARLMDGATEVKCSEFGEELIKNMD*" /label="icd CDS" gene complement(2415613..2416884) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /label="icd gene" misc_feature complement(2416669..2416688) /Source="Nicolas_upshift_promotors" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2416681) /Source="Nicolas_upshifts" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2416885..2416967) /Source="Nicolas_S_feature" /locus_tag="new_2980988_2981070_c" /HighExp="T2.30H, M40t90, T1.0H, T-3.40H, HiOs, T3.30H, T3.0H, T0.0H, Lbstat, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1099" upshifts complement(2416967) /Source="Nicolas_upshifts" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="upshifts" S_feature complement(2416969..2417047) /Source="Nicolas_S_feature" /locus_tag="new_2981072_2981150_c" /HighExp="T2.30H, T3.30H, T1.0H, M40t90, T3.0H, Lbstat, M0t90, T0.0H, HiOs, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1100" promotor_-10 complement(2416969..2416988) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-10" promotor_-35 complement(2417004..2417008) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-35" CDS complement(2417048..2418166) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase II" /protein_id="NP_390792.1" /db_xref="EnsemblGenomes-Gn:BSU29140" /db_xref="EnsemblGenomes-Tr:CAB14874" /db_xref="GOA:P39120" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR011278" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG10855" /db_xref="UniProtKB/Swiss-Prot:P39120" /translation="MTATRGLEGVVATTSSVSSIIDDTLTYVGYDIDDLTENASFEEI IYLLWHLRLPNKKELEELKQQLAKEAAVPQEIIEHFKSYSLENVHPMAALRTAISLLG LLDSEADTMNPEANYRKAIRLQAKVPGLVAAFSRIRKGLEPVEPREDYGIAENFLYTL NGEEPSPIEVEAFNKALILHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLH GGANEGVMKMLTEIGEVENAEPYIRAKLEKKEKIMGFGHRVYKHGDPRAKHLKEMSKR LTNLTGESKWYEMSIRIEDIVTSEKKLPPNVDFYSASVYHSLGIDHDLFTPIFAVSRM SGWLAHILEQYDNNRLIRPRADYTGPDKQKFVPIEERA*" /label="citZ CDS" gene complement(2417048..2418166) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /label="citZ gene" downshifts 2417661 /Source="Nicolas_upshifts" /id="D1493" /incds=1 /nref=2 /ntot=63 /MaxReadThrough="1.41638" /MaxDrop="3.70762" /score="40.6931963" /energy="-9.9" /TU="NA" /idTUdmin="U2252" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" misc_feature 2418008..2418011 /Source="Nicolas_upshift_promotors" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2418016 /Source="Nicolas_upshifts" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2418145 /Source="Nicolas_upshifts" /id="D1494" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="2.98678" /MaxDrop="3.07929" /score="40.6931963" /energy="-9.9" /TU="U2252" /idTUdmin="U2252" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2418167..2418373) /Source="Nicolas_S_feature" /locus_tag="new_2982270_2982476_c" /HighExp="T3.0H, T3.30H, T2.30H, T4.0H, M0t90, T2.0H, T1.30H, T5.0H, BC, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1101" misc_feature 2418341..2418353 /Source="Nicolas_upshift_promotors" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2418352 /Source="Nicolas_upshifts" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2418359..2418378) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2418373) /Source="Nicolas_upshifts" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2418393..2418397) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2418493) /Source="Nicolas_upshifts" /id="D1495" /incds=0 /nref=116 /ntot=204 /MaxReadThrough="6.4946" /MaxDrop="5.00031" /score="29.3344463" /energy="-8.1" /TU="NA" /idTUdmin="U2255" /TUdmin=14 /isTUend="TRUE" /label="downshifts" CDS complement(2418500..2418964) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390793.1" /db_xref="EnsemblGenomes-Gn:BSU29150" /db_xref="EnsemblGenomes-Tr:CAB14875" /db_xref="GOA:O34811" /db_xref="InterPro:IPR007382" /db_xref="SubtiList:BG13933" /db_xref="UniProtKB/Swiss-Prot:O34811" /translation="MFTQANLFLILLLAIALIAKNQSLLFAVSVLLIIKIVGLDQKLF PTIQSKGINWGVTIITIAVLVPIATGEIGFKQLGEAMRSSYAWIALGAGIAVALIAKN GLTLLENDPHITTALVIGTILAVALFGGVAVGPLIGAGIAYLAMQIVKLFTS*" /label="ytwI CDS" gene complement(2418500..2418964) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /label="ytwI gene" promotor_-10 complement(2418977..2418996) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2418991) /Source="Nicolas_upshifts" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2418993..2420178) /Source="Nicolas_S_feature" /locus_tag="new_2983096_2984281_c" /HighExp="G135, G180, LBGstat, G150, LBGtran, S0, Paraq, Oxctl, H2O2, LBGexp" /AntisenseName="ytvI" /AntisenseCor="-0.73323145377324295" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1102" promotor_-35 2418993..2418998 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2419009..2419017) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2419013..2419031 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2419019 /Source="Nicolas_upshifts" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="upshifts" CDS 2419061..2420176 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12662922, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sporulation-related permease" /protein_id="NP_390794.1" /db_xref="EnsemblGenomes-Gn:BSU29160" /db_xref="EnsemblGenomes-Tr:CAB14876" /db_xref="GOA:O34991" /db_xref="InterPro:IPR002549" /db_xref="InterPro:IPR014227" /db_xref="SubtiList:BG13930" /db_xref="UniProtKB/Swiss-Prot:O34991" /translation="MNQSYITIFFRTLFVISMTAGSIAAAYYSFPLTYPFLIALILSS VIHPVVDYLDKVTGFPRTINVLGVLAFFLLAAFGVLTILVAEIVTGTAYLAKTLPPHI STFISYCEKLFTTHIQPLYNELTLLFQELETNQQASIVTHIQTLGDSAAKNAGLLLSH ILEMIPRFFALLPNTAAVLIFSLLATFFMTKDWHKLKAMLVLILPDRVTANSKAISSE LKKAMTGFIKAQAVLVFITMVIVFIGLSLLKVEHAATIAFLIGLVDLLPYLGAGSVFV PWILYLSITGQLPQAIGIGILYLVVLIQRQLTEPKILSKSIGIDPLATLIALFAGFKL FGFLGLIAGPAVLVIIQAFITTGALKEIWSYITVQQK*" /label="ytvI CDS" gene 2419061..2420176 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /label="ytvI gene" downshifts 2420147 /Source="Nicolas_upshifts" /id="D1496" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.639" /MaxDrop="3.31897" /score="37.6858539" /energy="-16.7" /TU="NA" /idTUdmin="U2256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2420209..2420592) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15302217, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390795.1" /db_xref="EnsemblGenomes-Gn:BSU29170" /db_xref="EnsemblGenomes-Tr:CAB14877" /db_xref="GOA:O32064" /db_xref="InterPro:IPR007313" /db_xref="SubtiList:BG13935" /db_xref="UniProtKB/Swiss-Prot:O32064" /translation="MRFLFLLFIVFPAIEIGIFLFLGNLIGILPTVLFMILTGIIGAA AAKKQGTEVYYKVQRDLQYGKMPGEAIADGLCIFIGGLLLMLPGFLSDLAGACLLIPF TRGWCKPILFKWLRGMSKNKRIIIK*" /label="ytzA CDS" gene complement(2420209..2420592) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /label="ytzA gene" downshifts complement(2420223) /Source="Nicolas_upshifts" /id="D1497" /incds=0 /nref=181 /ntot=256 /MaxReadThrough="4.28884" /MaxDrop="5.74703" /score="18.319512" /energy="-13.8" /TU="NA" /idTUdmin="U2257" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2420593..2420684) /Source="Nicolas_S_feature" /locus_tag="new_2984696_2984787_c" /HighExp="G135, LBGtran, G150, LBGexp, M0t45, Lbexp, S0, G180, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1103" CDS complement(2420685..2422442) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /EC_number="2.7.1.40" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate kinase" /protein_id="NP_390796.1" /db_xref="EnsemblGenomes-Gn:BSU29180" /db_xref="EnsemblGenomes-Tr:CAB14878" /db_xref="GOA:P80885" /db_xref="InterPro:IPR001697" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR011037" /db_xref="InterPro:IPR015793" /db_xref="InterPro:IPR015795" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018209" /db_xref="InterPro:IPR036918" /db_xref="SubtiList:BG12661" /db_xref="UniProtKB/Swiss-Prot:P80885" /translation="MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHG ARIKNIREASKKLGKNVGILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTD KISVTYEGLVHDVEQGSTILLDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNV PGVSVNLPGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQII PKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVIT ATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASR SEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKY RPQAPIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDL IVITAGTVGESGTTNLMKVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKMTDGA VLVTKSTDRDMIASLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQ DITVDASRGAVYQGRASVL*" /label="pyk CDS" gene complement(2420685..2422442) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /label="pyk gene" CDS complement(2422485..2423444) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /EC_number="2.7.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12450869, 12622823, 12682299, 19193632, 20473954, 22198292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450869, 12622823, 12682299, 19193632, 20473954, 22198292; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phosphofructokinase" /protein_id="NP_390797.1" /db_xref="EnsemblGenomes-Gn:BSU29190" /db_xref="EnsemblGenomes-Tr:CAB14879" /db_xref="GOA:O34529" /db_xref="InterPro:IPR000023" /db_xref="InterPro:IPR012003" /db_xref="InterPro:IPR012828" /db_xref="InterPro:IPR015912" /db_xref="InterPro:IPR022953" /db_xref="InterPro:IPR035966" /db_xref="PDB:4A3S" /db_xref="SubtiList:BG12644" /db_xref="UniProtKB/Swiss-Prot:O34529" /translation="MKRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGL ISGKIEKLELGSVGDIIHRGGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGG DGSYMGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSH ERTYVIEVMGRHAGDIALWAGLAGGAESILIPEADYDMHEIIARLKRGHERGKKHSII IVAEGVGSGVEFGKRIEEETNLETRVSVLGHIQRGGSPSAADRVLASRLGAYAVELLL EGKGGRCVGIQNNKLVDHDIIEILETKHTVEQNMYQLSKELSI*" /label="pfkA CDS" gene complement(2422485..2423444) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /label="pfkA gene" S_feature complement(2423445..2423546) /Source="Nicolas_S_feature" /locus_tag="new_2987548_2987649_c" /HighExp="G150, LBGtran, LBGexp, Lbexp, dia0, G180, G135, Oxctl, LBGstat, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1104" promotor_-10 complement(2423535..2423554) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2423546) /Source="Nicolas_upshifts" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2423570..2423574) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2423628..2424605) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase alpha subunit)" /protein_id="NP_390798.1" /db_xref="EnsemblGenomes-Gn:BSU29200" /db_xref="EnsemblGenomes-Tr:CAB14880" /db_xref="GOA:O34847" /db_xref="InterPro:IPR001095" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12557" /db_xref="UniProtKB/Swiss-Prot:O34847" /translation="MAPRLEFEKPVIELQTKIAELKKFTQDSDMDLSAEIERLEDRLA KLQDDIYKNLKPWDRVQIARLADRPTTLDYIEHLFTDFFECHGDRAYGDDEAIVGGIA KFHGLPVTVIGHQRGKDTKENLVRNFGMPHPEGYRKALRLMKQADKFNRPIICFIDTK GAYPGRAAEERGQSEAIAKNLFEMAGLRVPVICIVIGEGGSGGALGLGVGNHLHMLEN STYSVISPEGAAALLWKDSSLAKKAAETMKITAPDLKELGIIDHMIKEVKGGAHHDVK LQASYMDETLKQSLKTLLKLSEEELVQQRYEKYKAIGKVSVEDQYIGVN*" /label="accA CDS" gene complement(2423628..2424605) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /label="accA gene" downshifts complement(2423655) /Source="Nicolas_upshifts" /id="D1498" /incds=0 /nref=48 /ntot=176 /MaxReadThrough="5.40549" /MaxDrop="5.53933" /score="-3.96100458" /energy="-6.8" /TU="U2259,U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2424590..2425462) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /EC_number="6.4.1.2" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 14594796, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase betasubunit)" /protein_id="NP_390799.2" /db_xref="EnsemblGenomes-Gn:BSU29210" /db_xref="EnsemblGenomes-Tr:CAB14881" /db_xref="GOA:C0SP93" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13926" /db_xref="UniProtKB/Swiss-Prot:C0SP93" /translation="MLKDIFTKKKKYASVPSDQAKHDVPEGIMTKCPKCKKIMLTKEL DKNMRVCMNCDYHFPMNAKQRIESLMDEQSFEEFNQGMLSENPLGFPGYLEKLEKDRE KTSLNEAVVTGKGTIGGHPAVVAVMDSSFRMGSMGSVVGEKITLAIEKAKADKVPFII FTASGGARMQEGVLSLMQMAKTSSALKLFSEEQGLIISVMTHPTTGGVSASFASLGDY NFAEPGALIGFAGRRIIEQTIGEKLPEDFQTAEFLLKHGQLDAVIHRDDMKKTLENLL DMHQTGGDIEWLQD*" /label="accD CDS" gene complement(2424590..2425462) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /label="accD gene" promotor_-35 2425424..2425429 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2425445..2425463 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2425449..2426623 /Source="Nicolas_S_feature" /locus_tag="new_2989552_2990726" /HighExp="S5, S8, S6, S7, C30, S4, C90, S3, T5.0H, BC" /AntisenseName="ytsJ" /AntisenseCor="-0.46008986922877199" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1105" upshifts 2425449 /Source="Nicolas_upshifts" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2425463..2425546) /Source="Nicolas_S_feature" /locus_tag="new_2989566_2989649_c" /HighExp="LBGstat, T4.0H, LBGtran, T5.0H, C30, dia15, M9-stat, Oxctl, LBGexp, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1106" promotor_-10 complement(2425535..2425554) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2425546) /Source="Nicolas_upshifts" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2425548..2425700) /Source="Nicolas_S_feature" /locus_tag="new_2989651_2989803_c" /HighExp="Diami, BC, dia15, Sw, dia5, M40t90, H2O2, S2, G/S, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1107" promotor_-35 complement(2425570..2425574) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2425702..2425796) /Source="Nicolas_S_feature" /locus_tag="new_2989805_2989899_c" /HighExp="dia15, LBGtran, LBGstat, Diami, LoTm, C90, GM 120, MG 60, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1108" downshifts complement(2425745) /Source="Nicolas_upshifts" /id="D1499" /incds=0 /nref=52 /ntot=158 /MaxReadThrough="7.72399" /MaxDrop="4.5863" /score="-3.96100458" /energy="-6.8" /TU="U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-2178" /isTUend="FALSE" /label="downshifts" CDS complement(2425797..2427029) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /EC_number="1.1.1.40" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 22740702, 23136871, 24325460, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 22740702, 23136871, 24325460, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP-dependent malic enzyme (conversion of malate into pyruvate, anabolic)" /protein_id="NP_390800.1" /db_xref="EnsemblGenomes-Gn:BSU29220" /db_xref="EnsemblGenomes-Tr:CAB14882" /db_xref="GOA:O34962" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG13922" /db_xref="UniProtKB/Swiss-Prot:O34962" /translation="MSLREEALHLHKVNQGKLESKSKVEVRNAKDLSLAYSPGVAEPC KDIHEDINKVYDYTMKGNMVAVVTDGTAVLGLGNIGPEAALPVMEGKAVLFKSFAGVD AFPIALNTNDVDKIVETVKLLEPTFGGVNLEDIAAPNCFIIEERLKKETNIPVFHDDQ HGTAIVTVAGLVNALKLSGKSMSSIKVVANGAGAAGIAIIKLLHHYGVRDIVMCDSKG AIYEGRPNGMNDVKNEVAKFTNQDRKDGSLKDVIVDADVFIGVSVAGALTKEMVQSMA KDPIIFAMANPNPEIMPEDAREAGASVVGTGRSDFPNQVNNVLAFPGIFRGALDVRAT HINEEMKIAAVEAIASLVSEDELSADYVIPAPFDKRVAPAVAKAVAKAAMETGVARIT VDPEEVAEKTRKLTIIGE*" /label="maeB CDS" gene complement(2425797..2427029) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /label="maeB gene" S_feature complement(2427030..2427146) /Source="Nicolas_S_feature" /locus_tag="new_2991133_2991249_c" /HighExp="dia15, Diami, LBGstat, H2O2, LBGtran, dia5, M40t45, Lbtran, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1109" promotor_-10 complement(2427134..2427153) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2427146) /Source="Nicolas_upshifts" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" CDS complement(2427166..2430513) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit), DnaE3" /protein_id="NP_390801.1" /db_xref="EnsemblGenomes-Gn:BSU29230" /db_xref="EnsemblGenomes-Tr:CAB14883" /db_xref="GOA:O34623" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004805" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR029460" /db_xref="SubtiList:BG12583" /db_xref="UniProtKB/Swiss-Prot:O34623" /translation="MSFVHLQVHSGYSLLNSAAAVEELVSEADRLGYASLALTDDHVM YGAIQFYKACKARGINPIIGLTASVFTDDSELEAYPLVLLAKSNTGYQNLLKISSVLQ SKSKGGLKPKWLHSYREGIIAITPGEKGYIETLLEGGLFEQAAQASLEFQSIFGKGAF YFSYQPFKGNQVLSEQILKLSEETGIPVTATGDVHYIRKEDKAAYRCLKAIKAGEKLT DAPAEDLPDLDLKPLEEMQNIYREHPEALQASVEIAEQCRVDVSLGQTRLPSFPTPDG TSADDYLTDICMEGLRSRFGKPDERYLRRLQYELDVIKRMKFSDYFLIVWDFMKHAHE KGIVTGPGRGSAAGSLVAYVLYITDVDPIKHHLLFERFLNPERVSMPDIDIDFPDTRR DEVIQYVQQKYGAMHVAQIITFGTLAAKAALRDVGRVFGVSPKEADQLAKLIPSRPGM TLDEARQQSPQLDKRLRESSLLQQVYSIARKIEGLPRHASTHAAGVVLSEEPLTDVVP LQEGHEGIYLTQYAMDHLEDLGLLKMDFLGLRNLTLIESITSMIEKEENIKIDLSSIS YSDDKTFSLLSKGDTTGIFQLESAGMRSVLKRLKPSGLEDIVAVNALYRPGPMENIPL FIDRKHGRAPVHYPHEDLRSILEDTYGVIVYQEQIMMIASRMAGFSLGEADLLRRAVS KKKKEILDRERSHFVEGCLKKEYSVDTANEVYDLIVKFANYGFNRSHAVAYSMIGCQL AYLKAHYPLYFMCGLLTSVIGNEDKISQYLYEAKGSGIRILPPSVNKSSFPFTVENGS VRYSLRAIKSVGVSAVKDIYKARKEKPFEDLFDFCFRVPSKSVNRKMLEALIFSGAMD EFGQNRATLLASIDVALEHAELFAADDDQMGLFLDESFSIKPKYVETEELPLVDLLAF EKETLGIYFSNHPLSAFRKQLTAQGAVSILQAQRAVKRQLSLGVLLSKIKTIRTKTGQ NMAFLTLSDETGEMEAVVFPEQFRQLSPVLREGALLFTAGKCEVRQDKIQFIMSRAEL LEDMDAEKAPSVYIKIESSQHSQEILAKIKRILLEHKGETGVYLYYERQKQTIKLPES FHINADHQVLYRLKELLGQKNVVLKQW*" /label="dnaEC CDS" gene complement(2427166..2430513) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /label="dnaEC gene" promotor_-35 complement(2427167..2427174) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2428178..2428187 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2428199..2428214 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2428199 /Source="Nicolas_upshifts" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2428387..2428406) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2428406) /Source="Nicolas_upshifts" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2428420..2428427) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2430544..2430563) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2430562) /Source="Nicolas_upshifts" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" promotor_-35 complement(2430577..2430584) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2430602..2430607 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-35" upshifts 2430619 /Source="Nicolas_upshifts" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="upshifts" promotor_-10 2430623..2430641 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-10" CDS 2430653..2430994 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="membrane protein involved in a sporulation process" /protein_id="YP_003097771.1" /db_xref="EnsemblGenomes-Gn:BSU29239" /db_xref="EnsemblGenomes-Tr:CAX52677" /db_xref="GOA:C0H3P8" /db_xref="InterPro:IPR025689" /db_xref="UniProtKB/Swiss-Prot:C0H3P8" /translation="MDQEAGFMVNFINSYFIALGVLIGGALIGGLGAYLAGEPPLTAI TKLANRLKIWALVAAIGGTFDAVYSFERGILEGNTRDIFKQLLLIISAMGGAQSGWLI ISWLTQEHLSS*" /label="ytrH CDS" gene 2430653..2430994 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /label="ytrH gene" CDS 2430991..2431494 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="protein involved in sporulation" /protein_id="NP_390802.3" /db_xref="EnsemblGenomes-Gn:BSU29240" /db_xref="EnsemblGenomes-Tr:CAB14884" /db_xref="GOA:O34460" /db_xref="SubtiList:BG13917" /db_xref="UniProtKB/Swiss-Prot:O34460" /translation="MRVPQHYKKPGWQRFFAGMMCGAVISWFFFLFTYGTFQEEQVSL IEKQKEHVKDLNNQISIYQEDLHKLNEDNKRKLLIQSVSVKLLNGDKYKISQPDKTKF EEHVKDDISEVITKDIESVYQTKDLLKRTIENKVYMINEKKYEATVRELIIYTRLTVE LEISFAT*" /label="ytrI CDS" gene 2430991..2431494 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /label="ytrI gene" promotor_-35 2431527..2431530 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2431545..2431564 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2431545 /Source="Nicolas_upshifts" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" CDS 2431596..2431787 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative sporulation-related conserved protein" /protein_id="YP_003097772.1" /db_xref="EnsemblGenomes-Gn:BSU29249" /db_xref="EnsemblGenomes-Tr:CAX52678" /db_xref="UniProtKB/Swiss-Prot:C0H3P9" /translation="MEVYSDRQLAKDQAARLRQGFSAYAETNSLASLIKKELQSHNLQ VYEDLTDFGCWFIPVTDEH*" /label="ytzJ CDS" gene 2431596..2431787 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /label="ytzJ gene" downshifts complement(2431597) /Source="Nicolas_upshifts" /id="D1500" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.45109" /MaxDrop="3.19151" /score="-1.37123732" /energy="-6.5" /TU="NA" /idTUdmin="U2268" /TUdmin=220 /isTUend="FALSE" /label="downshifts" downshifts 2431763 /Source="Nicolas_upshifts" /id="D1501" /incds=0 /nref=15 /ntot=107 /MaxReadThrough="6.88261" /MaxDrop="6.74738" /score="-8.58003897" /energy="-4" /TU="U2265" /idTUdmin="U2264" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2431805..2432746) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /EC_number="3.1.3.7" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17586819, 19553197, 22102036, 26735940, 28894100" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17586819, 19553197, 22102036, 26735940, 28894100; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nanoRNase (oligoribonuclease) (3'->5'short substrates, 5'->3' long substrates), 3',5'-bisphosphate nucleotidase" /protein_id="NP_390803.1" /db_xref="EnsemblGenomes-Gn:BSU29250" /db_xref="EnsemblGenomes-Tr:CAB14885" /db_xref="GOA:O34600" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="PDB:5IPP" /db_xref="PDB:5IUF" /db_xref="PDB:5IZO" /db_xref="PDB:5J21" /db_xref="SubtiList:BG13910" /db_xref="UniProtKB/Swiss-Prot:O34600" /translation="MKTELIRTISLYDTIILHRHVRPDPDAYGSQCGLTEILRETYPE KNIFAVGTPEPSLSFLYSLDEVDNETYEGALVIVCDTANQERIDDQRYPSGAKLMKID HHPNEDPYGDLLWVDTSASSVSEMIYELYLEGKEHGWKLNTKAAELIYAGIVGDTGRF LFPNTTEKTLKYAGELIQYPFSSSELFNQLYETKLNVVKLNGFIFQNVSLSENGAASV FIKKDTLEKFGTTASEASQLVGTLGNISGIRAWVFFVEEDDQIRVRFRSKGPVINGLA RKYNGGGHPLASGASIYSWDEADRILADLETLCKEHE*" /label="nrnA CDS" gene complement(2431805..2432746) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /label="nrnA gene" S_feature 2431808..2432179 /Source="Nicolas_S_feature" /locus_tag="new_2995911_2996282" /HighExp="Lbstat, S2, M0t90, M40t90, nit, ferm, S3, BT, M9-stat, S0" /AntisenseName="nrnA" /AntisenseCor="-0.77648424268923499" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1110" downshifts complement(2431840) /Source="Nicolas_upshifts" /id="D1502" /incds=0 /nref=25 /ntot=163 /MaxReadThrough="3.12169" /MaxDrop="3.09205" /score="22.5196409" /energy="-7.9" /TU="U2268" /idTUdmin="U2269" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2432148..2432157 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2432171..2432190 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2432181..2432575 /Source="Nicolas_S_feature" /locus_tag="new_2996284_2996678" /HighExp="Lbstat, S2, S7, S8, S6, nit, ferm, M0t90, BT, M40t90" /AntisenseName="nrnA" /AntisenseCor="-0.85531073541330804" /AntisenseRegPval="-77.5" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1111" upshifts 2432181 /Source="Nicolas_upshifts" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2432537..2432543 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2432559..2432578 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2432577..2432876 /Source="Nicolas_S_feature" /locus_tag="new_2996680_2996979" /HighExp="Lbstat, S8, S7, S6, S2, Etha, nit, ferm, BT, M0t90" /AntisenseName="nrnA" /AntisenseCor="-0.84034645112995598" /AntisenseRegPval="-72.2" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1112" upshifts 2432577 /Source="Nicolas_upshifts" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2432765..2432784) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2432781) /Source="Nicolas_upshifts" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2432783..2433197) /Source="Nicolas_S_feature" /locus_tag="new_2996886_2997300_c" /HighExp="LBGtran, HiTm, G180, G135, G150, Lbtran, LBGexp, Mt0, Paraq, dia0" /AntisenseName="ytpI" /AntisenseCor="-0.70134306018551296" /AntisenseRegPval="-40.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1113" promotor_-35 complement(2432799..2432802) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2432877..2433179 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390804.1" /db_xref="EnsemblGenomes-Gn:BSU29260" /db_xref="EnsemblGenomes-Tr:CAB14886" /db_xref="GOA:O34922" /db_xref="InterPro:IPR025618" /db_xref="SubtiList:BG13902" /db_xref="UniProtKB/Swiss-Prot:O34922" /translation="MLVLVFLIGLSACFYVYYKVKGVRAKPSLAKEICSAKSSMALGS LVLFYGLNQMILFHSVLTLVIGGIFIVIGAGSAWAGYKAFRHYNPLHAKEAERDHA*" /label="ytpI CDS" gene 2432877..2433179 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /label="ytpI gene" S_feature 2433180..2434975 /Source="Nicolas_S_feature" /locus_tag="new_2997283_2999078" /HighExp="S8, S6, S7, Lbstat, B36, nit, ferm, T1.0H, C30, S5" /AntisenseName="ytoI" /AntisenseCor="-0.55304378374907204" /AntisenseRegPval="-22.2" /CDS_PredictionProba="0.89152299999999995" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1114" CDS complement(2433198..2434517) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26296725" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390805.1" /db_xref="EnsemblGenomes-Gn:BSU29270" /db_xref="EnsemblGenomes-Tr:CAB14887" /db_xref="GOA:O34921" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR010766" /db_xref="InterPro:IPR028979" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13897" /db_xref="UniProtKB/Swiss-Prot:O34921" /translation="MATKHEQILTYIDSLPVGEKISVRRIAKEMKVSEGTAYRAIKEA ENKGFVSTIERVGTIRIEQKKKENIEKLTYAEVVNVIDGQVLGGRAGLHKTLNKFVIG AMELDAMMRYTAAGNLLIVGNRINAHRQALEAGAAVLVTGGFNTDDSIVQLADELELP ILSTSYDTFTVAAMINRAIYDQLIKKEIVLVEDILTPADRTVYLSPKDKLEKWYEKNF ETGHGRFPVVDDQMKIHGILTSKDIAGHDRNASIEKVMTKNPVTVIGKTSVASAAQMM VWEGIEVLPVTDGHQKLIGMISRQDVLKALQMIQKQPQVGEKLDDIVSRGFKDEGDDK EDQTVYEYEVTPQMTNQLGTISYGVFTTILTQAANRFLRSKKRGELVIESITIFFLKP VQMESVIEVKPRILEAGRKFGKMEVEVHSQGHIVSKAMLMVQLMERS*" /label="ytoI CDS" gene complement(2433198..2434517) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /label="ytoI gene" promotor_-10 complement(2434543..2434562) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2434564) /Source="Nicolas_upshifts" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2434577..2434582) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2434693..2435595) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390806.1" /db_xref="EnsemblGenomes-Gn:BSU29280" /db_xref="EnsemblGenomes-Tr:CAB14888" /db_xref="GOA:O34430" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13894" /db_xref="UniProtKB/Swiss-Prot:O34430" /translation="MKKLIVFAFIGLLSQLIDGSLGMAYGVTSTSLLLAFGITPAVAS ASVHLAEVVTTAASGVSHIKFGNVDKQTVYQLVIPGSIGAFLGAAFLSQLPGDVAKPY ISLFLLLLGGYVLIRFLFQYKPALEKKHVPLNRKQSIPLGVIAGFADATGGGGWGPVT TPILLSRKGLSPRKVVGTVDTSEFAIAVSATAGFLISLGWEDVNWLWVFSLMAGGIIA APIAAWLVQKFHPQLMGVLVGGFIILVNARTLINEWIANTAVHPLIYTAIGAIWLSAV LFVLSKIGNRNIVKTAVDVHLKEK*" /label="ytnM CDS" gene complement(2434693..2435595) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /label="ytnM gene" CDS complement(2435614..2436864) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10588044, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10588044, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-alkyl-N-acetyl-metabolite deacetylase" /protein_id="NP_390807.1" /db_xref="EnsemblGenomes-Gn:BSU29290" /db_xref="EnsemblGenomes-Tr:CAB14889" /db_xref="GOA:O34980" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12596" /db_xref="UniProtKB/Swiss-Prot:O34980" /translation="MSLDYWRNIEGSYPYQTTGNDILTLKEESNPVNLSTLEKQLIGI RRHLHQYPELSKEEFETTAFIKKCLKEKGIQIRPTALKTGVFADIAGESEGPAIALRA DIDALPIEEKTGLPYASKHKGIMHACGHDFHTAALLGAAFLLKENQDSLKGKIRLLFQ PAEEAGAGATKVIEDGQLDGIDAVIGLHNKPDIAVGTVGLKTGPLMAAVDRFKVEIEG KGAHAALPHNGFDPIIGASQLIVALQTIVSRNVNPLQSAILTVGKINGGSTWNVIPDT VVIEGTVRTFDSEVRNQVKQRFFAVTEQISAAFSLKANVKWHSGPPPLCNDEAITGLV RDAAHKAKLQVIDPAPSTAGEDFAYYLEHIPGSFAFFGTDGDHDWHHPAFTIDETAII KASYFLYESAKRLLDSNEESKISD*" /label="sndA CDS" gene complement(2435614..2436864) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /label="sndA gene" CDS complement(2436882..2437574) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FMN-riboswitch-binding activator of rib genes" /protein_id="NP_390808.1" /db_xref="EnsemblGenomes-Gn:BSU29300" /db_xref="EnsemblGenomes-Tr:CAB14890" /db_xref="GOA:P94465" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11969" /db_xref="UniProtKB/Swiss-Prot:P94465" /translation="MTIIAGTVVKGKQLGRKLGFPTANVDAKIHGLRNGVYGVLATVN HQFHLGVMNIGVKPTVGSNLEKTLEIFLFDFHRDIYGEKIECSILFKIREERRFDSLE SLTKQIKKDISCVAKRFELIGIMAPNKKESLLSHQELNLPDLCFYKKCNNLYGVNRGV YNVIDNWFFEYGITQVAYRRIYILSFLSFLKEDNPKVSSKYIRFGAGGLADKLNRFIS SYVEESEENILG*" /label="ribR CDS" gene complement(2436882..2437574) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /label="ribR gene" CDS complement(2437621..2438949) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390809.1" /db_xref="EnsemblGenomes-Gn:BSU29310" /db_xref="EnsemblGenomes-Tr:CAB14891" /db_xref="GOA:O34974" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="PDB:1TVL" /db_xref="PDB:1YW1" /db_xref="SubtiList:BG13893" /db_xref="UniProtKB/Swiss-Prot:O34974" /translation="MTRADFIQFGAMIHGVGGTTDGWRHPDVDPSASTNIEFYMKKAQ TAEKGLFSFIFIADGLFISEKSIPHFLNRFEPITILSALASVTKNIGLVGTFSTSFTE PFTISRQLMSLDHISGGRAGWNLVTSPQEGAARNHSKSNLPEHTERYEIAQEHLDVVR GLWNSWEHDAFIHNKKTGQFFDQAKLHRLNHKGKYFQVEGPLNIGRSKQGEPVVFQAG SSETGRQFAAKNADAIFTHSNSLEETKAFYADVKSRAADEGRDPSSVRIFPGISPIVA DTEEEAEKKYREFAELIPIENAVTYLARFFDDYDLSVYPLDEPFPDIGDVGKNAFQST TDRIKREAKARNLTLREVAQEMAFPRTLFIGTPERVASLIETWFNAEAADGFIVGSDI PGTLDAFVEKVIPILQERGLYRQDYRGGTLRENLGLGIPQHQSVLHSSHH*" /label="cmoJ CDS" gene complement(2437621..2438949) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /label="cmoJ gene" CDS complement(2438946..2439227) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redoxin" /protein_id="NP_390810.1" /db_xref="EnsemblGenomes-Gn:BSU29320" /db_xref="EnsemblGenomes-Tr:CAB14892" /db_xref="GOA:O34639" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13892" /db_xref="UniProtKB/Swiss-Prot:O34639" /translation="MSDVVNIVVWSKKGCSYCEEVKNYLNEKGFPFQNIDVSEKEKLR DILQVKYGVRHVPVVEIGRGNQYQGITEIGIEHLDLALANHAQIKEAKR*" /label="cmoI CDS" gene complement(2438946..2439227) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /label="cmoI gene" CDS complement(2439242..2440246) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9836433, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9836433, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390811.1" /db_xref="EnsemblGenomes-Gn:BSU29330" /db_xref="EnsemblGenomes-Tr:CAB14893" /db_xref="GOA:O34846" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG13888" /db_xref="UniProtKB/Swiss-Prot:O34846" /translation="MIRLSILDQSLIGEGETAADTLQHTVKLAQMAEECGYHRFWVAE HHNNDEIAGSAPEVLLGYLAASTRKIRLASGGVMLQHYSSYKVAEQFHLLSALAPGRI DLGVGKAPGGFQLSTDALQAEYKKPVRQFDEKLEELTHFVRDDFPDTHRYAALRPRPQ VDRKPGIFLLGGSTESAISAAKLGISFVFAYFINGEEEVLKEARRAFDAHLPPGSEAE FHLAPAVFAAHTKEEAEKHIVSRESIKVVLKDGRKVNVGSREQAEAYLENVTEPYDII VQKTGIIAGTKEEVAEELTRLSGTYKINDFVIFTPIKNAVEKQLSYQLLSDAVLAAKR *" /label="cmoO CDS" gene complement(2439242..2440246) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /label="cmoO gene" CDS complement(2440243..2441022) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino-acid ABC transporter (ATP-binding protein)" /protein_id="NP_390812.1" /db_xref="EnsemblGenomes-Gn:BSU29340" /db_xref="EnsemblGenomes-Tr:CAB14894" /db_xref="GOA:O34900" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG12604" /db_xref="UniProtKB/Swiss-Prot:O34900" /translation="MIEIKNIHKQFGIHHVLKGINLTVRKGEVVTIIGPSGSGKTTFL RCLNLLERPDEGIISIHDKVINCRFPSKKEVHWLRKQTAMVFQQYHLFAHKTVIENVM EGLTIARKMRKQDAYAVAENELRKVGLQDKLNAYPSQLSGGQKQRVGIARALAIHPDV LLFDEPTAALDPELVGEVLEVMLEIVKTGATMIVVTHEMEFARRVSDQVVFMDEGVIV EQGTPEEVFRHTKKDRTRQFLRRVSPEYLFEPKEHIKEPVI*" /label="tcyN CDS" gene complement(2440243..2441022) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /label="tcyN gene" CDS complement(2441019..2441726) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390813.1" /db_xref="EnsemblGenomes-Gn:BSU29350" /db_xref="EnsemblGenomes-Tr:CAB14895" /db_xref="GOA:O34931" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13887" /db_xref="UniProtKB/Swiss-Prot:O34931" /translation="MQFDFPFIVSAMKEMVKTIPLTLMMAVLPIVFGFLVALGNIIVR IFRIKGLVACSRFYVSFFRSTPAILHIMLIYLGIPPVADQVSSFFHLGWSANEIPVSM FVIMALSLTAGAYLTEIIRSGILAMDTGQVEAAYSIGLTYSQTFRRVILPQALKVSIP NFTNLGIGFLHTTSIAAIVAVPEITGTATIVASDNYAFLEAFIGAAIIYWVLTLILES ANGVLERKAARFQGGTL*" /label="tcyM CDS" gene complement(2441019..2441726) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /label="tcyM gene" CDS complement(2441756..2442475) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390814.1" /db_xref="EnsemblGenomes-Gn:BSU29360" /db_xref="EnsemblGenomes-Tr:CAB14896" /db_xref="GOA:O34315" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13886" /db_xref="UniProtKB/Swiss-Prot:O34315" /translation="MEKAFDMNMIGDFVPTLTAYLPVTLYILTLSLLFGFVLGLFLAL PRIYNIPIVNQLAKVYISFFRGTPIMVQLFIVFYGIPALTGLIGIDTSKMDPFYAAVA TYALSNAAAAAEIIRAGVGSVDKGQTEAAYSIGLSGSQAFRRIVLPQALVQAFPNMGN MVISSLKDTSLAFSIGVMDMSGRGQTLITSSNHSLEVYIALSIVYYAVAVLFEWFFRV AEKRIKKNQTRIVTVFDMNIH*" /label="tcyL CDS" gene complement(2441756..2442475) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /label="tcyL gene" promotor_-35 2442301..2442308 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2442323..2442342 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2442323 /Source="Nicolas_upshifts" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2442497..2443309) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 22720735, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 22720735, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390815.1" /db_xref="EnsemblGenomes-Gn:BSU29370" /db_xref="EnsemblGenomes-Tr:CAB14897" /db_xref="GOA:O34852" /db_xref="InterPro:IPR001638" /db_xref="PDB:2O1M" /db_xref="SubtiList:BG13885" /db_xref="UniProtKB/Swiss-Prot:O34852" /translation="MKTKTAFMAILFSLITVLSACGAGSQTTGAGQKKVQTITVGTGT QFPNICFIDEKGDLTGYDVELIKELDKRLPHYKFTFKTMEFSNLLVSLGQHKVDIVAH QMEKSKEREKKFLFNKVAYNHFPLKITVLQNNDTIRGIEDLKGKRVITSATSNGALVL KKWNEDNGRPFEIAYEGQGANETANQLKSGRADATISTPFAVDFQNKTSTIKEKTVGN VLSNAKVYFMFNKNEQTLSDDIDKALQEIIDDGTLKRLSLKWLGDDYSKEQY*" /label="tcyK CDS" gene complement(2442497..2443309) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /label="tcyK gene" CDS complement(2443323..2444132) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390816.1" /db_xref="EnsemblGenomes-Gn:BSU29380" /db_xref="EnsemblGenomes-Tr:CAB14898" /db_xref="GOA:O34406" /db_xref="InterPro:IPR001638" /db_xref="SubtiList:BG13884" /db_xref="UniProtKB/Swiss-Prot:O34406" /translation="MNKRKGLVLLLSVFALLGGGCSQTNNKTDRQAQTVIVGTGTDFP NIAFLNEKGELTGYDIEVMKAIDKELPQYTFEFKTMDFSNLLTSLGNKKIDVIAHNMA KNKEREKRFLYHKVPYNYSPMYITVKEDNHKIHTLKDLHGKTVIVGATSNAADYITKY NKTHGSPIHLKYAGQGSNDTANQIETGRADATIATPFAVDFQNKTHAFRQKTVGDVLL DTEVYFMFNKGSQTLADDTDQAIKKLEKNGTLKKLSRKWLGADYSKSSFEK*" /label="tcyJ CDS" gene complement(2443323..2444132) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /label="tcyJ gene" CDS complement(2444146..2444682) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyltransferase acting on sulfur compounds" /protein_id="NP_390817.1" /db_xref="EnsemblGenomes-Gn:BSU29390" /db_xref="EnsemblGenomes-Tr:CAB14899" /db_xref="GOA:O34350" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13883" /db_xref="UniProtKB/Swiss-Prot:O34350" /translation="MSDDIFRLATVEDASELLKLVNSAFQPIRQLDIDWPSTRADIQM VSENIEHHSAIVLERDGKLISTITIRFPWESETPPSKYPFVWWFATLPEYKGQGAGSK LLTYVEEKVLRDMLKAPALTLGTSARKHPWLADMYRRRGYEVYFEQEKDGDIGVMMHK VLIPERFNPTLLGAPSWA*" /label="snaA CDS" gene complement(2444146..2444682) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /label="snaA gene" promotor_-35 2444719..2444726 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2444737..2444756) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2444740..2444759 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2444743..2444834 /Source="Nicolas_S_feature" /locus_tag="new_3008846_3008937" /HighExp="dia5, MG 5, UNK1, MG t5, MG 10, B60, dia0, nit, Diami, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1115" upshifts 2444743 /Source="Nicolas_upshifts" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2444753) /Source="Nicolas_upshifts" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2444770..2444777) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2444835..2445761 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of operon snaA-ytnM degrading cysteine-containing compounds (AscR-N-acetylcysteine)" /protein_id="NP_390818.1" /db_xref="EnsemblGenomes-Gn:BSU29400" /db_xref="EnsemblGenomes-Tr:CAB14900" /db_xref="GOA:O35038" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13877" /db_xref="UniProtKB/Swiss-Prot:O35038" /translation="MELRSIKTFHTIVKFGSFYKAAEILNYSQPTISMRMKQLEQDLG VLLFERGKSLQLTKAGKLFYERTGDLLMQYEALKHNLSDLKEEEAGIINIGVSEPTAS LIFPEILKDFLMDYPKITVNIKVDDANTCSQKLLDGTIDFAVCGEPELILENYYHPFF YDTLNVIVSDQHPLAEKKAVHLSDLAEERFIFTPANCPIRLQIEQHLHRELGNRYKKM ELTSSMSHEYYVRENIGISIFTSTAHSKPFNGTKVIPILNLDITPPIGLLTNQKEVHF DRATKDLIARITKRFQQRSKELEGTSDKTITG*" /label="ascR CDS" gene 2444835..2445761 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /label="ascR gene" S_feature complement(2445237..2445766) /Source="Nicolas_S_feature" /locus_tag="new_3009340_3009869_c" /HighExp="Etha, dia15, dia5, H2O2, M9-stat, M40t90, Sw, Gly, M0t90, Cold" /AntisenseName="ytlI" /AntisenseCor="-7.8012588423369304E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1116" downshifts complement(2445811) /Source="Nicolas_upshifts" /id="D1503" /incds=0 /nref=142 /ntot=251 /MaxReadThrough="4.32965" /MaxDrop="5.01142" /score="39.1547987" /energy="-16.5" /TU="U2273" /idTUdmin="U2274" /TUdmin=20 /isTUend="TRUE" /label="downshifts" CDS complement(2445812..2446495) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390819.2" /db_xref="EnsemblGenomes-Gn:BSU29410" /db_xref="EnsemblGenomes-Tr:CAB14901" /db_xref="GOA:Q795U4" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR022877" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13871" /db_xref="UniProtKB/Swiss-Prot:Q795U4" /translation="MKVTYHGHSVITVETKDHHIIFDPFLTGNSLTDIKPEDVKADVI LLTHGHNDHVGDTEQIAKQNNALVIAPNELAVYLGWKGLNVHPMHIGGSRQFDFGKVK LTQAFHGSAITDEENKTITYTGMPAGILLTVEDKTIFHAGDTALFSDMKLIGELNHID LAFLPIGDNFTMGPEDAKLAAEWLRAKQVVPVHYNTFPVIEQDPEAFADSLPGGVGKV MSVGETIEL*" /label="ytkL CDS" gene complement(2445812..2446495) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /label="ytkL gene" S_feature complement(2446496..2446557) /Source="Nicolas_S_feature" /locus_tag="new_3010599_3010660_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, M0t90, M40t90, Salt, LBGtran, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1117" CDS complement(2446558..2447325) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_390820.1" /db_xref="EnsemblGenomes-Gn:BSU29420" /db_xref="EnsemblGenomes-Tr:CAB14902" /db_xref="GOA:O34308" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13870" /db_xref="UniProtKB/Swiss-Prot:O34308" /translation="MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKE ACPDCLDRLQFVKGDVTKKEDLLRIAEAALNRFGRIDFLINNAGPYIFERKKLADYTD DEWYGMLEGNLSAVFHLFKAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKV GLASLTKTIAIEEAEFGITANMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGE DIARIIAFLCEENSDLVTGTVIEATGGLNVINKNQTT*" /label="ytkK CDS" gene complement(2446558..2447325) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /label="ytkK gene" promotor_-10 complement(2447370..2447389) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2447392) /Source="Nicolas_upshifts" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2447405..2447407) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2447452..2447688) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11423008" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390821.3" /db_xref="EnsemblGenomes-Gn:BSU29430" /db_xref="EnsemblGenomes-Tr:CAB14903" /db_xref="SubtiList:BG13938" /db_xref="UniProtKB/Swiss-Prot:O34503" /translation="MKKRKLAWQQEFVKISFIKSRHYSQPTSIMMGGRMMKKEPERYI YDEQESQETTRLISEAYQSGYVDMPDQESSSPAE*" /label="ytzD CDS" gene complement(2447452..2447688) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /label="ytzD gene" downshifts 2447537 /Source="Nicolas_upshifts" /id="D1504" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="0.55049" /MaxDrop="4.17437" /score="-5.88070891" /energy="-8.9" /TU="NA" /idTUdmin="U2271" /TUdmin=1782 /isTUend="FALSE" /label="downshifts" downshifts complement(2447557) /Source="Nicolas_upshifts" /id="D1505" /incds=0 /nref=199 /ntot=288 /MaxReadThrough="5.44889" /MaxDrop="6.29233" /score="21.2322542" /energy="-8.5" /TU="U2274" /idTUdmin="U2274" /TUdmin="-1726" /isTUend="FALSE" /label="downshifts" CDS complement(2447648..2449033) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /EC_number="4.3.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 9890879, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 9890879, 11423008; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate lyase" /protein_id="NP_390822.1" /db_xref="EnsemblGenomes-Gn:BSU29440" /db_xref="EnsemblGenomes-Tr:CAB14904" /db_xref="GOA:O34858" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR009049" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="InterPro:IPR029419" /db_xref="SubtiList:BG12571" /db_xref="UniProtKB/Swiss-Prot:O34858" /translation="MKKLWGGRFQKTPEKWVDEFGASISFDQNLVAEDITGSLAHAAM LKKCGILTAEEELKIREGLNTLLQKAEEGALEFSVDYEDIHLNIEKMLIDEIGPLGGK LHTGRSRNDQVATDMHLYLKNHVGHIIELIEAFQSALIEKAEANVETILPGYTHLQRA QPISFAHHLLAYFWMLERDKERFQDSMKRINKSPLGCGALAGTTFPIDRDYSAELLGF DAIYENSLDGVSDRDFILEFLSNSSMLMMHLSRFSEEIILWCSQEFKFIELDDTYATG SSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKDLQEDKEGMFDTVKT VEGSLQIFTGMIQTMTVNKDVMKQATKQDFSNATELADYLAKKGMPFREAHEVVGKLV YTCIERGIYLSDMPFGEFQQASTLFEEDIYTVLDPYYAVEKRMSAGGTGFKQVEQALE KAKACVAAGVC*" /label="argH CDS" gene complement(2447648..2449033) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /label="argH gene" CDS complement(2449030..2450241) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /EC_number="6.3.4.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 11423008, 12963366, 17611193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 11423008, 12963366, 17611193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate synthase" /protein_id="NP_390823.1" /db_xref="EnsemblGenomes-Gn:BSU29450" /db_xref="EnsemblGenomes-Tr:CAB14905" /db_xref="GOA:O34347" /db_xref="InterPro:IPR001518" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018223" /db_xref="InterPro:IPR023434" /db_xref="InterPro:IPR024074" /db_xref="SubtiList:BG12570" /db_xref="UniProtKB/Swiss-Prot:O34347" /translation="MSEQKKVVLAYSGGLDTSVAIKWLQEQGYNVIACCLDVGEGKDL AFVQQKALEVGATNSYVIDAKEEFAQDYALISLQAHTMYEGKYPLVSALSRPLIAKKL VEIAEKEDAQAIAHGCTGKGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAA SRGIPIPINLDSPYSIDQNLWGRANECGILEDPWAAPPEGAYDLTAPLEKTPDTPEVI EIAFEQGVPVSIDGVSYSLSELILKLNEMAGAHGVGRIDHVENRLVGIKSREVYECPG AMTLIKAHKELEDLTLVKEVAHFKPIIEQKMSEIIYNGLWFSPLKDALHAFLKETQKH VTGIVRVKLFKGHAIVEGRKSEYSLYDEKLATYTKDDAFDHHAAIGFIELWGLPTKVN SIVKKKEQIKA*" /label="argG CDS" gene complement(2449030..2450241) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /label="argG gene" S_feature complement(2450242..2450319) /Source="Nicolas_S_feature" /locus_tag="new_3014345_3014422_c" /HighExp="S1, MG 15, T3.0H, T3.30H, T4.0H, T5.0H, BMM, T2.30H, T-0.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1118" promotor_-10 complement(2450312..2450331) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2450318) /Source="Nicolas_upshifts" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2450346..2450353) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2450411..2450923) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15269205, 20054111, 23680484; Product type f: factor" /codon_start=1 /transl_table=11 /product="molybdopterin GTP-binding precursor Z biosynthesis component" /protein_id="NP_390824.1" /db_xref="EnsemblGenomes-Gn:BSU29460" /db_xref="EnsemblGenomes-Tr:CAB14924" /db_xref="GOA:O34457" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008284" /db_xref="InterPro:IPR012245" /db_xref="InterPro:IPR036425" /db_xref="SubtiList:BG12618" /db_xref="UniProtKB/Swiss-Prot:O34457" /translation="MSVQEHKQEAPDIVRCKVITVSDTRTDETDKSGKLMISFLEEAG HHIAAYEIVKDEKDALQRSVLAGCMDEQTDAVLLNGGTGIADRDVTIEAITPLFSKEL PGFGEIFRMLSYTEDIGSAAIMSRATAGVIQHTAVFSTPGSSGAVKLAMNKLIIPELA HVVREIRKDK*" /label="moaB CDS" gene complement(2450411..2450923) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /label="moaB gene" downshifts complement(2450429) /Source="Nicolas_upshifts" /id="D1506" /incds=0 /nref=122 /ntot=221 /MaxReadThrough="1.48097" /MaxDrop="4.78155" /score="25.7910606" /energy="-10.8" /TU="NA" /idTUdmin="U2275" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2450949..2450968) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2450957) /Source="Nicolas_upshifts" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2450982..2450989) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2451008..2452195) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /EC_number="2.7.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8226682, 9811655, 11244084, 16995897, 19019159, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226682, 9811655, 11244084, 16995897, 19019159, 26098117; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetate kinase" /protein_id="NP_390825.1" /db_xref="EnsemblGenomes-Gn:BSU29470" /db_xref="EnsemblGenomes-Tr:CAB14925" /db_xref="GOA:P37877" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR004372" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG10813" /db_xref="UniProtKB/Swiss-Prot:P37877" /translation="MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTI SVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNEIDGIGHRVVHGGEKFSDSVL LTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY SLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEG GKSIDTSMGFTPLAGVAMGTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGIS GFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDAIIFTAGIGENS VEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVR LAK*" /label="ackA CDS" gene complement(2451008..2452195) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /label="ackA gene" downshifts complement(2451023) /Source="Nicolas_upshifts" /id="D1507" /incds=0 /nref=13 /ntot=117 /MaxReadThrough="5.03131" /MaxDrop="3.1641" /score="19.2403206" /energy="-9.9" /TU="U2276" /idTUdmin="U2277" /TUdmin=242 /isTUend="FALSE" /label="downshifts" S_feature complement(2452196..2452300) /Source="Nicolas_S_feature" /locus_tag="new_3016299_3016403_c" /HighExp="dia0, Lbexp, LBGtran, Oxctl, LPh, M0t45, HPh, Paraq, H2O2, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1119" promotor_-10 complement(2452285..2452304) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2452300) /Source="Nicolas_upshifts" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2452302..2452431) /Source="Nicolas_S_feature" /locus_tag="new_3016405_3016534_c" /HighExp="S5, S6, S7, S8, S4, dia5, BT, H2O2, dia15, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1120" promotor_-35 complement(2452320..2452324) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2452368..2452571) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513997.1" /translation="MMNGLKKKSKCFKSSLDSRMRSMPKLLLFMLLKTGLDELNPALK HKIQREKPQIVSVHQYKTYSECV*" /label="hypothetical protein CDS" gene complement(2452368..2452571) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /label="gene" promotor_-10 complement(2452429..2452440) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2452431) /Source="Nicolas_upshifts" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2452455..2452461) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2452543..2453532) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid methyltransferase" /protein_id="NP_390826.1" /db_xref="EnsemblGenomes-Gn:BSU29480" /db_xref="EnsemblGenomes-Tr:CAB14926" /db_xref="GOA:P37876" /db_xref="InterPro:IPR003356" /db_xref="InterPro:IPR016843" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10812" /db_xref="UniProtKB/Swiss-Prot:P37876" /translation="MQKDHVGAVYELLNEAAIMIKNELQISYIEALAEAGEMYFLEKT DQLKLPADQKTKQLQALLEKAEFGTYEHEWVRKAFQLAVLKGMKDISHPNRQMTPDTI GLFISYLVNKFMADKKELTILDPALGTGNLLFTVLNQLSEKTANSFGIEIDDVLLKIA YAQANLLKKELELFHQDSLEPLFIDPVDTVICDLPVGYYPNDEGAEAFELKADEGHSF AHHLFIEQSVKHTKPGGYLFFMIPNHLFESSQSGKLKQFFKDKVHINALLQLPKSIFK DEAHAKSILVLQKQGENTKAPGQILLANLPSFSNQKAMLDMMAQFDEWFKKEK*" /label="ytxK CDS" gene complement(2452543..2453532) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /label="ytxK gene" downshifts complement(2452561) /Source="Nicolas_upshifts" /id="D1508" /incds=0 /nref=158 /ntot=243 /MaxReadThrough="3.51469" /MaxDrop="5.25938" /score="-4.33730173" /energy="-13.3" /TU="NA" /idTUdmin="U2279" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2453593..2454096) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486061, 18588855, 18588855, 23899494, 25355936, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486061, 18588855, 18588855, 23899494, 25355936, 25852656; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol peroxidase (lipid hydroperoxide reductase)" /protein_id="NP_390827.1" /db_xref="EnsemblGenomes-Gn:BSU29490" /db_xref="EnsemblGenomes-Tr:CAB14927" /db_xref="GOA:P80864" /db_xref="InterPro:IPR002065" /db_xref="InterPro:IPR013740" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR018219" /db_xref="InterPro:IPR036249" /db_xref="PDB:2JSY" /db_xref="PDB:2JSZ" /db_xref="SubtiList:BG13855" /db_xref="UniProtKB/Swiss-Prot:P80864" /translation="MAEITFKGGPVTLVGQEVKVGDQAPDFTVLTNSLEEKSLADMKG KVTIISVIPSIDTGVCDAQTRRFNEEAAKLGDVNVYTISADLPFAQARWCGANGIDKV ETLSDHRDMSFGEAFGVYIKELRLLARSVFVLDENGKVVYAEYVSEATNHPNYEKPIE AAKALVK*" /label="tpx CDS" gene complement(2453593..2454096) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /label="tpx gene" downshifts complement(2453599) /Source="Nicolas_upshifts" /id="D1509" /incds=0 /nref=53 /ntot=241 /MaxReadThrough="6.94509" /MaxDrop="4.3179" /score="9.29337297" /energy="-10.1" /TU="U2279" /idTUdmin="U2280" /TUdmin=548 /isTUend="FALSE" /label="downshifts" promotor_no_box 2453813..2453913 /Source="Nicolas_upshift_promotors" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2453873 /Source="Nicolas_upshifts" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2454092 /Source="Nicolas_upshifts" /id="D1510" /incds=0 /nref=86 /ntot=184 /MaxReadThrough="2.23568" /MaxDrop="5.49495" /score="20.1242958" /energy="-12.7" /TU="NA" /idTUdmin="U2278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2454119..2454138) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2454135) /Source="Nicolas_upshifts" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2454152..2454159) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2454206..2454661) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /experiment="publication(s) with functional evidences, PMID:23921501, 25790435, 27881417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23921501, 25790435, 27881417; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination-associated protein" /protein_id="NP_390828.1" /db_xref="EnsemblGenomes-Gn:BSU29500" /db_xref="EnsemblGenomes-Tr:CAB14928" /db_xref="GOA:O34806" /db_xref="InterPro:IPR014229" /db_xref="SubtiList:BG13849" /db_xref="UniProtKB/Swiss-Prot:O34806" /translation="MADHPIQGLMKTAMENLKEMIDVNTIIGDPVETPDGSVILTVSK VGFGFAAGGSEFGGKPAEKKSEDDETREQKLPFGGGSGGGVSITPIAFLIVGSTGIRM LHLDENTHLIEKILDAAPQTLERIQQMFKKNNKNQSQGQNQNQMNNMNY*" /label="gerW CDS" gene complement(2454206..2454661) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /label="gerW gene" downshifts complement(2454234) /Source="Nicolas_upshifts" /id="D1511" /incds=0 /nref=38 /ntot=91 /MaxReadThrough="3.69502" /MaxDrop="5.65648" /score="26.1939476" /energy="-12.7" /TU="U2280" /idTUdmin="U2280" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" CDS complement(2454675..2455355) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390829.1" /db_xref="EnsemblGenomes-Gn:BSU29510" /db_xref="EnsemblGenomes-Tr:CAB14929" /db_xref="InterPro:IPR021338" /db_xref="SubtiList:BG13848" /db_xref="UniProtKB/Swiss-Prot:O34917" /translation="MVYVLTAILILIGIVLLLRMKIHVALEYLHADDNDKLTLKITAL FGLIRIKKTIPAIKVNKEDGTVDIKQKTESKMKKSSGKKKITQNDVQQSINKIEMLLH QVTRLRKISASFLAHLHITKLEWVTVIGIQDAAVTGVLTGAVWGVKGGIAAMLYDHLD FVNKPVYEVIPSFQVPVSKTHFQCIFFFRFGHAMLAAFKFVKYGRELSVLKKNPSARM TSKNDSSV*" /label="ytfI CDS" gene complement(2454675..2455355) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /label="ytfI gene" upshifts complement(2454767) /Source="Nicolas_upshifts" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="upshifts" promotor_-10 complement(2454774..2454785) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-10" promotor_-35 complement(2454800..2454806) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-35" downshifts complement(2455093) /Source="Nicolas_upshifts" /id="D1512" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.64036" /MaxDrop="2.98792" /score="28.0381876" /energy="-11.8" /TU="U2281" /idTUdmin="U2281" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2455368..2455386) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-10" upshifts complement(2455382) /Source="Nicolas_upshifts" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="upshifts" promotor_-35 complement(2455401..2455406) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-35" CDS complement(2455430..2455924) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390830.1" /db_xref="EnsemblGenomes-Gn:BSU29520" /db_xref="EnsemblGenomes-Tr:CAB14930" /db_xref="GOA:O34424" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG13840" /db_xref="UniProtKB/Swiss-Prot:O34424" /translation="MDATYEELERNDIKGPQEAELLTHAYAGFWVRFWAFLLDWLVIW GLNHLLVSPLFTVLDLPKTSGMFTFSAYSVTTLIVYLAYFALMTKYFRQTLGKMVFGL KVVSVKQDSKLTWSTVIFREVVGRYIDKIWILYIVVAFSPTKQGIHDYIADTTVVHEK LYRK*" /label="yteJ CDS" gene complement(2455430..2455924) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /label="yteJ gene" downshifts complement(2455445) /Source="Nicolas_upshifts" /id="D1513" /incds=0 /nref=240 /ntot=258 /MaxReadThrough="1.43721" /MaxDrop="6.8315" /score="28.0381876" /energy="-11.8" /TU="NA" /idTUdmin="U2282" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2455937..2456944) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9987136, 10455123, 16484219, 22472423, 23155385, 24228759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 10455123, 16484219, 22472423, 23155385, 24228759; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="signal peptide peptidase" /protein_id="NP_390831.1" /db_xref="EnsemblGenomes-Gn:BSU29530" /db_xref="EnsemblGenomes-Tr:CAB14931" /db_xref="GOA:O34525" /db_xref="InterPro:IPR002142" /db_xref="InterPro:IPR004635" /db_xref="InterPro:IPR029045" /db_xref="PDB:3RST" /db_xref="PDB:4KWB" /db_xref="SubtiList:BG13839" /db_xref="UniProtKB/Swiss-Prot:O34525" /translation="MNAKRWIALVIALGIFGVSIIVSISMSFFESVKGAQTDLTSLTD ESQEKTLENGSPSSKIAVLEVSGTIQDNGDSSSLLGADGYNHRTFLKNLERAKDDKTV KGIVLKVNSPGGGVYESAEIHKKLEEIKKETKKPIYVSMGSMAASGGYYISTAADKIF ATPETLTGSLGVIMESVNYSKLADKLGISFETIKSGAHKDIMSPSREMTKEEKNIMQS MVDNSYEGFVDVISKGRGMPKAEVKKIADGRVYDGRQAKKLNLVDELGFYDDTITAMK KDHKDLKNASVISYEESFGLGSLFSMGANKMFKSEIDFLNMREILSQSGSPRMMYLYA K*" /label="sppA CDS" gene complement(2455937..2456944) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /label="sppA gene" promotor_-10 complement(2456968..2456983) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2456985) /Source="Nicolas_upshifts" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2456987..2457066) /Source="Nicolas_S_feature" /locus_tag="new_3021090_3021169_c" /HighExp="LBGexp, Oxctl, LBGtran, dia0, H2O2, dia15, G180, G150, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1121" promotor_-35 complement(2456995..2457004) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2457044..2457063 /Source="Nicolas_upshift_promotors" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2457054 /Source="Nicolas_upshifts" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2457059..2457078) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2457063..2457129 /Source="Nicolas_S_feature" /locus_tag="new_3021166_3021232" /HighExp="M0t90, Sw, M9-stat, BC, M40t90, T4.0H, T2.30H, S1, T3.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1122" upshifts complement(2457066) /Source="Nicolas_upshifts" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2457094..2457098) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2457130..2457933 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /EC_number="2.7.1.23" /function="16.7: Manage energy" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897004, 16233726, 16511117, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase" /protein_id="NP_390832.1" /db_xref="EnsemblGenomes-Gn:BSU29540" /db_xref="EnsemblGenomes-Tr:CAB14932" /db_xref="GOA:O34934" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13837" /db_xref="UniProtKB/Swiss-Prot:O34934" /translation="MTDQRRNVYFFHKQDQETNEQARSLTQLAEEHGFTVVNQHSDAN IIASIGGDGTFLQAVRKTNFRDDCLYVGITKKGKAHLYCDFHSDEREKMVDAMTFEQI EVRKYPLIEVTVDQASPFHCLNEVSIRSSIIKTFVMDVLIDDLHFETFRGDGMIISTP TGSTAYNKSVAGAVVDPLLPCMQVSELASLNNNTYRTLGSPFVLSSDRKLTLRVVQDG NEHPIIGLDNEALSTRNVKTIEIKLSNKKIKTVKLKDNSFWEKVKRTFL*" /label="ppnKB CDS" gene 2457130..2457933 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /label="ppnKB gene" downshifts 2457863 /Source="Nicolas_upshifts" /id="D1514" /incds=1 /nref=46 /ntot=222 /MaxReadThrough="5.39036" /MaxDrop="3.90238" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-124" /isTUend="FALSE" /label="downshifts" downshifts 2457921 /Source="Nicolas_upshifts" /id="D1515" /incds=0 /nref=6 /ntot=54 /MaxReadThrough="3.14676" /MaxDrop="4.64552" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2457965..2459554) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19433221, 20386924, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-substituted formamide deformylase, dihydropyrimidinase or isoaspartyl peptidase" /protein_id="NP_390833.1" /db_xref="EnsemblGenomes-Gn:BSU29550" /db_xref="EnsemblGenomes-Tr:CAB14933" /db_xref="GOA:O34355" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR013108" /db_xref="InterPro:IPR032466" /db_xref="InterPro:IPR033932" /db_xref="SubtiList:BG13835" /db_xref="UniProtKB/Swiss-Prot:O34355" /translation="MKAIWHGGFIYTMLEEGDRTEAVYVEDGVIKGTGSYERLKEKYG SPETEEISLNGAVMFPGFVDSHLHLIGHGEKQLQLDLSALTSKDSILQAAKERERQLP KNDWLIGEGWNENQFETPDYLTKHDLDRLFPDRPVLLKRICRHAIAVNSAALQAAGIS RNTPDPDGGVIVKDANGEPTGLLFDKAQDLILKAVPPVSQHYVDEALTAAIKDCWTKG LTGGHSEDLSYYGDVSVPMKAYEKAAAGGKYPFRCHLLVHHEAVDRWEQLEKLSGPYV EFGAMKIFADGALGGRTALLKEPYQDDPSTNGVQVHDDETLGRLIRKAREKGMEVAVH AIGDLAFEKVLNAIEKHPPKNGRHDRLIHAQVLDNELIERAARMPIALDLQPHFVASD FPWVIDRLGKDRMKTAFAWKTLISKGILCAGGSDAPIEPVDPLLGIQSAVLRKSSHEQ NGPSYNESECLPVYEAIKLYTEGSAGIIYKEKSRGKIAEGYDADFTVLSGDPFAIDPA QLHLLEIKKTVINGQIVYEKS*" /label="ytcJ CDS" gene complement(2457965..2459554) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /label="ytcJ gene" downshifts complement(2457974) /Source="Nicolas_upshifts" /id="D1516" /incds=0 /nref=149 /ntot=255 /MaxReadThrough="2.61299" /MaxDrop="5.92403" /score="32.0110789" /energy="-13.8" /TU="NA" /idTUdmin="U2285" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2459574..2461163) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /EC_number="6.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-coenzyme A synthetase" /protein_id="NP_390834.2" /db_xref="EnsemblGenomes-Gn:BSU29560" /db_xref="EnsemblGenomes-Tr:CAB14934" /db_xref="GOA:C0SPB0" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13834" /db_xref="UniProtKB/Swiss-Prot:C0SPB0" /translation="MLKREDLIAPVQYNLVNEMEKFSAAGQKTALLWEDESGKQESWS YEKLMEETNKIGAALADLGFKKGDKLIVMVPRVLEAYAVYLAILKSGMVVIPCSEMLR AKDLEYRIEHAEVKGAIVYSEFIGAFRDVSTADKLITLSIGENDAGWKNLLSIEADGS QFKTADTTRDDMAFLSYTSGTTGQPKGVVHTHGWAFAHLKTSAGAWLDISEKDIVWAT AAPGWQKWVWSPFLAVLGSGATGFVYHGRFKAEKYLELLNRYKINVFCCTPTEYRLMA KVEGLKRFDLSALHSAVSAGEPLNREVIDVFQKHFGIKVRDGYGQTESTLLVGVLKDT PIKPGSMGKPTPGNQVEIINEDGEICKPGEVGDIAVHLSTPALFKEYFKDPERMKTQI RGDYFLTGDRARKDEEGYFWFESRNDDIIISSGYTIGPFEVEDALVKHPEVKECAVVA SPDEIRGSIVKAYVVLQNHEKRSDELVKMLQNHVKTITAPYKYPREIEFVESLPKTAS AKIRRVELRKREEQLKANKKA*" /label="ytcI CDS" gene complement(2459574..2461163) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /label="ytcI gene" promotor_-10 complement(2461209..2461226) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2461214) /Source="Nicolas_upshifts" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2461242..2461248) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2461341) /Source="Nicolas_upshifts" /id="D1517" /incds=0 /nref=242 /ntot=266 /MaxReadThrough="2.32229" /MaxDrop="9.17935" /score="30.5720337" /energy="-13.3" /TU="NA" /idTUdmin="U2287" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2461342..2461551) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:2456528, 2468649, 3009398, 16707666" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2456528, 2468649, 3009398, 16707666; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha-type SASP)" /protein_id="NP_390835.1" /db_xref="EnsemblGenomes-Gn:BSU29570" /db_xref="EnsemblGenomes-Tr:CAB14935" /db_xref="GOA:P04831" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10786" /db_xref="UniProtKB/Swiss-Prot:P04831" /translation="MANNNSGNSNNLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRA NGSVGGEITKRLVSFAQQNMGGGQF*" /label="sspA CDS" gene complement(2461342..2461551) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /label="sspA gene" promotor_-35 2461547..2461551 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2461551 /Source="Nicolas_upshifts" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2461560..2461574 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2461572..2461583) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2461583) /Source="Nicolas_upshifts" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2461598..2461604) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2461645..2462850) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /EC_number="2.8.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14757766, 16343540, 22773787, 24705700, 28287455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14757766, 16343540, 22773787, 24705700, 28287455; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="persulfide ATP pyrophosphatase involved in tRNA modification" /protein_id="NP_390836.2" /db_xref="EnsemblGenomes-Gn:BSU29580" /db_xref="EnsemblGenomes-Tr:CAB14936" /db_xref="GOA:O34595" /db_xref="InterPro:IPR003720" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020536" /db_xref="SubtiList:BG13827" /db_xref="UniProtKB/Swiss-Prot:O34595" /translation="MNYDHILIRFGEISTKGKNRKSFIERLKQNIRLVLKDYPNLKYF SNRDRMTITLNGEDPEALFPHLKQVFGIQSFSLAIKCDSRLDDIKATALKAIKDQYKP GDTFKVATKRAYKQFELDTNQMNAEIGGHILRNTEGLTVDVRNPDIPLRIEIREEATF LTIRDEKGAGGLPVGSAGKAMLMLSGGFDSPVAGFYAMKRGLSVEAVHFFSPPYTSER AKQKVMDLAKCLSRFGGSMTLHIVPFTKTQELIQKQIPENYTMTATRRLMLQIADRIR EKRNGLAIITGESLGQVASQTLESMYAINAVTSTPILRPLIAMDKTEIIEKSREIGTY ETSIQPFEDCCTIFTPPSPKTRPKKEKIEHFESFVDFEPYIQEAVDNIETMTLYSEQE ANDKFAELF*" /label="trmG CDS" gene complement(2461645..2462850) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /label="trmG gene" CDS complement(2462854..2463999) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_390837.1" /db_xref="EnsemblGenomes-Gn:BSU29590" /db_xref="EnsemblGenomes-Tr:CAB14937" /db_xref="GOA:O34874" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="SubtiList:BG12632" /db_xref="UniProtKB/Swiss-Prot:O34874" /translation="MIYLDNSSTTKPYDEVLNVYEQTSSRYFGNPSSLHRYGAETEQL LQAAKNQIKRSLGLKKYDIVFTSGATEANNAALKGAALSKIKTGKHIIATSIEHPSVT ESLEQLKELFGFDITYLSVNEDGFVSIEDLKAAIRPDTVLVSMMHVNNEVGSVQPIEA AGEVLKEHSNILFHVDYVQGIYKVPLAIEKAGIDLCSISGHKFHGLKGTGALIVKEGT RLIPLITGGSQQKGIRAGTEHTAGAVSLAKAINLASADFDTRLDTMTAVKELFMNRLS EIEGVVINTPQMNSAPHIINFSVPGIKAEVLLHMLEEQDIFVSTTSACSAKEHKPSKV LLEMGKGEQIAGSSIRISLNYSQTSDVAEPFMNALRPGIKKLREMMR*" /label="iscSB CDS" gene complement(2462854..2463999) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /label="iscSB gene" S_feature complement(2464000..2465143) /Source="Nicolas_S_feature" /locus_tag="new_3028103_3029246_c" /HighExp="Diami, dia15, dia5, H2O2, G135, G180, G150, C30, Paraq, LBGstat" /AntisenseName="braB" /AntisenseCor="0.41502288403214899" /AntisenseRegPval="-11.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1123" promotor_-35 2464086..2464093 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2464104..2464193 /Source="Nicolas_S_feature" /locus_tag="new_3028207_3028296" /HighExp="LPh, HPh, BMM, dia0, Heat, G180, Cold, LBGexp, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1124" upshifts 2464104 /Source="Nicolas_upshifts" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2464106..2464125 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2464194..2465531 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11528000, 15849754, 16850406, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11528000, 15849754, 16850406, 26473603; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid-Na+ symporter" /protein_id="NP_390838.1" /db_xref="EnsemblGenomes-Gn:BSU29600" /db_xref="EnsemblGenomes-Tr:CAB14938" /db_xref="GOA:O34545" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG12573" /db_xref="UniProtKB/Swiss-Prot:O34545" /translation="MKHSLPVKDTIIIGFMLFALFFGAGNMIYPPELGQAAGHNVWKA IGGFLLTGVGLPLLGIIAIALTGKDAKGLADKAHPVFGTIFTVVLYLSIGPLFAIPRT GTVSYEIGAVPFLTGVPERLSLLIFTLIFFGVTYYLALNPSKVVDRVGKILTPIKFTI ILIIVLKAIFTPMGGLGAVTEAYKGTPVFKGFLEGYKTMDALASIVFGVVVVNAVKSK GVTQSKALAAACIKAGVIAALGLTFIYVSLAYLGATSTNAIGPVGEGAKILSASSHYL FGSLGNIVLGAAITVACLTTSIGLVTSCGQYFSKLIPALSYKIVVTIVTLFSLIIANF GLAQIIAFSVPILSAIYPLAIVIIVLSFIDKIFKERREVYIACLIGTGLFSILDGIKA AGFSLGSLDVFLNANLPLYSLGIGWVLPGIVGAVIGYVLTLFIGPSKQLNEIS*" /label="braB CDS" gene 2464194..2465531 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /label="braB gene" promotor_-10 complement(2465129..2465148) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2465143) /Source="Nicolas_upshifts" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2465163..2465170) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2465507 /Source="Nicolas_upshifts" /id="D1518" /incds=0 /nref=69 /ntot=174 /MaxReadThrough="1.86149" /MaxDrop="6.26921" /score="14.5905051" /energy="-15.2" /TU="U2288" /idTUdmin="U2288" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2465626..2467314) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of FtsZ ring formation" /protein_id="NP_390839.1" /db_xref="EnsemblGenomes-Gn:BSU29610" /db_xref="EnsemblGenomes-Tr:CAB14939" /db_xref="GOA:O34894" /db_xref="InterPro:IPR010379" /db_xref="PDB:4UXV" /db_xref="SubtiList:BG13934" /db_xref="UniProtKB/Swiss-Prot:O34894" /translation="MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSI VEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKAN QVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHL YGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKL LADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDI DEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETEL VKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIE EVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLE NAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFG NRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA*" /label="ezrA CDS" gene complement(2465626..2467314) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /label="ezrA gene" downshifts complement(2465627) /Source="Nicolas_upshifts" /id="D1519" /incds=0 /nref=224 /ntot=257 /MaxReadThrough="3.34218" /MaxDrop="5.3305" /score="9.25784495" /energy="-8.6" /TU="U2290" /idTUdmin="U2290" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2467315..2467420) /Source="Nicolas_S_feature" /locus_tag="new_3031418_3031523_c" /HighExp="C90, Lbtran, BMM, LBGtran, MG 150, S1, Lbexp, dia0, LBGexp, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1125" promotor_-35 2467397..2467405 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2467408..2467427) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2467416..2467435 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2467420) /Source="Nicolas_upshifts" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" upshifts 2467420 /Source="Nicolas_upshifts" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2467421..2467510 /Source="Nicolas_S_feature" /locus_tag="new_3031524_3031613" /HighExp="HiOs, C90, dia5, T-5.40H, S1, T-3.40H, GM-0.1, GM 15, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1126" S_feature complement(2467422..2467981) /Source="Nicolas_S_feature" /locus_tag="new_3031525_3032084_c" /HighExp="Etha, Salt, Cold, G135, Lbstat, G180, G150, H2O2, Heat, Paraq" /AntisenseName="hisJ" /AntisenseCor="0.37018688255337001" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1127" promotor_-35 complement(2467443..2467445) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2467511..2468317 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /EC_number="3.1.3.15" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10322033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol phosphate phosphatase" /protein_id="NP_390840.1" /db_xref="EnsemblGenomes-Gn:BSU29620" /db_xref="EnsemblGenomes-Tr:CAB14940" /db_xref="GOA:O34411" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010140" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG13931" /db_xref="UniProtKB/Swiss-Prot:O34411" /translation="MQKRDGHIHTPFCPHGSNDTLRQYAEEALKKGFESITFTEHAPL PPSFTDPTPLKDSAMAQASLERYIHEISGLKKEYRGQLSIRTGLEVDYIAEFEDEITL FLDTYGPYLDDSILSVHFLRTDSSYLCLDYDEHTFKELISACGSIEAVYEQYYRSIYS SIVASLGVYKPKRVGHITLVQKFIKLFPYSMSEHIRGLVSLCLNAIEENGMELDFNTS GLRKTYAGGIYIEDWMLNEAKQKKIPLVFGSDAHQAGDVGYAYEAFLERC*" /label="hisK CDS" gene 2467511..2468317 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /label="hisK gene" promotor_-10 complement(2467985..2468004) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2467998) /Source="Nicolas_upshifts" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2468016..2468023) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2468267..2468313) /Source="Nicolas_S_feature" /locus_tag="new_3032370_3032416_c" /HighExp="M9-stat, T5.0H, LoTm, T4.0H, S2, BC, T3.30H, S4, T3.0H, B60" /AntisenseName="hisJ" /AntisenseCor="-0.46006853678527698" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1128" downshifts complement(2468289) /Source="Nicolas_upshifts" /id="D1520" /incds=0 /nref=51 /ntot=97 /MaxReadThrough="1.55523" /MaxDrop="6.84653" /score="-4.34170655" /energy="-10.5" /TU="NA" /idTUdmin="U2296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2468314..2468937) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11988534, 22730127, 26360512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 22730127, 26360512; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of FtsZ defining the chromosome regioncaptured in the forespore" /protein_id="NP_390841.1" /db_xref="EnsemblGenomes-Gn:BSU29630" /db_xref="EnsemblGenomes-Tr:CAB14941" /db_xref="GOA:O34970" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG13927" /db_xref="UniProtKB/Swiss-Prot:O34970" /translation="MKVSTKDKIIESAVMLFNQKGFSGTSVREIAKSADVNVAHISYY FKGKGGLMEHLVSEFYEGYSKTLETAASNISTQSTQEQLLQLVFDILSYQHNHRQLTR FVYREVTIDSTLIREIMSTYLMKEKYIFQLIIEEGEKQREYLTLPLPHFILQLKSLLM MPYLQPQYISEVLYMQPHEPYFYKMYFEEIKIWIRSVFRTGDVALTN*" /label="refZ CDS" gene complement(2468314..2468937) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /label="refZ gene" S_feature 2468318..2468660 /Source="Nicolas_S_feature" /locus_tag="new_3032421_3032763" /HighExp="C90, HiOs, Sw, dia5, GM-0.1, S1, MG 5, UNK1, MG 60, MG t5" /AntisenseName="yttP" /AntisenseCor="-0.79169109805002003" /AntisenseRegPval="-58.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1129" promotor_-35 2468638..2468645 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2468660..2468679 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2468662..2468805 /Source="Nicolas_S_feature" /locus_tag="new_3032765_3032908" /HighExp="Diami, dia15, dia5, H2O2, C90, Paraq, Salt, Etha, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.81457903975257295" /AntisenseRegPval="-64.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1130" upshifts 2468662 /Source="Nicolas_upshifts" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2468777..2468781 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2468797..2468816 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2468807..2468937 /Source="Nicolas_S_feature" /locus_tag="new_3032910_3033040" /HighExp="Diami, dia15, dia5, H2O2, Paraq, C90, HPh, LBGexp, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.82273476313537297" /AntisenseRegPval="-66.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1131" upshifts 2468807 /Source="Nicolas_upshifts" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2468939..2469063 /Source="Nicolas_S_feature" /locus_tag="new_3033042_3033166" /HighExp="Diami, dia5, dia15, H2O2, C90, BC, HiOs, Paraq, Sw, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.598, 0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1132" upshifts 2468939 /Source="Nicolas_upshifts" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2468953..2468971) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2468955..2468974 /Source="Nicolas_upshift_promotors" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2468971) /Source="Nicolas_upshifts" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2468982..2468990) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2469064..2469555 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /EC_number="1.8.4.14" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17535911, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="free methionine-(R)-sulfoxide reductase" /protein_id="NP_390842.2" /db_xref="EnsemblGenomes-Gn:BSU29640" /db_xref="EnsemblGenomes-Tr:CAB14942" /db_xref="InterPro:IPR000614" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG13923" /db_xref="UniProtKB/Swiss-Prot:O34553" /translation="MFHVEKQSGDKEKDYQLLLKQLEAMTEDETDQIANYANASALLY HSLPEVNWAGFYFAKEEDGQLVLGPFQGLPACVRIPFGRGVCGTAYANGKVERIEDVN AFPGHIACDAASQSEIVLPIRVDGKIVGVLDIDSPVKNRFDEIDEKYLTQFAETLEKA LAQ*" /label="msrC CDS" gene 2469064..2469555 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /label="msrC gene" downshifts 2469534 /Source="Nicolas_upshifts" /id="D1521" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="3.66093" /MaxDrop="6.50628" /score="34.0123402" /energy="-11.9" /TU="U2291,U2293,U2294" /idTUdmin="U2295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2469593..2471332) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /EC_number="2.7.7.65" /function="16.12: Sense" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_390843.1" /db_xref="EnsemblGenomes-Gn:BSU29650" /db_xref="EnsemblGenomes-Tr:CAB14943" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG13918" /db_xref="UniProtKB/Swiss-Prot:O34325" /translation="MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYF STLCVSLTPSPSDFVTKLADGEARFSASKINASCYLIEDGSGRRFHLACRQDEEIPEG LPDVVASFLNQSMKQERLYNKTIYQKKIYKMTELFHSLLDQTDVLKQLLESLTSTFSL FEFSLFISHDQDQCLGIPAKELYMEGEKSDSFALKVYLSGDILRKNESVAYIPIKGQQ GTYGVLKAEGTGDSFLTDACLDEMSLLANAAGKAFENAQLYEQSKASIANLELINETS RRLNQRLTLTDTMNDLAVRMAESFQAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDF YNELKEKLYEGEKGVFIGNGQSVFGKAGYGSLMAAPMIQNDRLLGFAVLLKQELYAFT FEMYKLFQALIHHATLAVTNSMLRDRLEHLVKTDQLTELYSRAYLDEKIQYSMKIHQK GVFILVDIDNFKNVNDTYGHQTGDEILIQVASVIKSNIRKHDVGARWGGEELAIYLPN VPVAVGKRITERLVYAVRKNTKPEVTISCGISCWTTETKKSLKELVHEADEALYSAKR SGKNRLMIHDSIK*" /label="dgcP CDS" gene complement(2469593..2471332) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /label="dgcP gene" downshifts complement(2469611) /Source="Nicolas_upshifts" /id="D1522" /incds=0 /nref=23 /ntot=178 /MaxReadThrough="3.68958" /MaxDrop="4.52201" /score="-0.637788006" /energy="-11.9" /TU="U2298" /idTUdmin="U2298" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" promotor_-35 2470806..2470813 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-35" promotor_-10 2470827..2470845 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-10" upshifts 2470830 /Source="Nicolas_upshifts" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="upshifts" S_feature 2470832..2471427 /Source="Nicolas_S_feature" /locus_tag="new_3034935_3035530" /HighExp="Cold, LBGstat, C30, Lbstat, GM 25, GM 10, GM 120, GM-0.1, GM 5, GM-0.2" /AntisenseName="ytrP" /AntisenseCor="-0.113221814489707" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1133" misc_feature complement(2471362..2471381) /Source="Nicolas_upshift_promotors" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2471370) /Source="Nicolas_upshifts" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2471372..2472205) /Source="Nicolas_S_feature" /locus_tag="new_3035475_3036308_c" /HighExp="Etha, S7, Gly, S8, M9-stat, Sw, G135, S6, BC, C30" /AntisenseName="rpsD" /AntisenseCor="-0.48019282175486899" /AntisenseRegPval="-16.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1134" promotor_-35 2471408..2471415 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2471429..2471626 /Source="Nicolas_S_feature" /locus_tag="new_3035532_3035729" /HighExp="UNK1, Cold, HPh, C30, aero, LPhT, MG 25, Oxctl, Heat, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.139124" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1135" promotor_-10 2471429..2471448 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2471429 /Source="Nicolas_upshifts" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2471486..2471618 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /product="ribosomal protein S4 leader mRNA sequence" /experiment="publication(s) with functional evidences, PMID:23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23611891" /label="ldsD RNA" gene 2471486..2471618 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /label="ldsD gene" CDS 2471627..2472229 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1400226, 1699930, 1906866, 12682299, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400226, 1699930, 1906866, 12682299, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S4 (BS4)" /protein_id="NP_390844.1" /db_xref="EnsemblGenomes-Gn:BSU29660" /db_xref="EnsemblGenomes-Tr:CAB14944" /db_xref="GOA:P21466" /db_xref="InterPro:IPR001912" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR005709" /db_xref="InterPro:IPR018079" /db_xref="InterPro:IPR022801" /db_xref="InterPro:IPR036986" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10372" /db_xref="UniProtKB/Swiss-Prot:P21466" /translation="MARYTGPSWKLSRRLGISLSGTGKELEKRPYAPGPHGPGQRKKL SEYGLQLQEKQKLRHMYGVNERQFRTLFDKAGKLAGKHGENFMILLDSRLDNVVYKLG LARTRRQARQLVNHGHILVDGSRVDIPSYLVKPGQTIGVREKSRNLSIIKESVEVNNF VPEYLTFDAEKLEGTFTRLPERSELAPEINEALIVEFYSR*" /label="rpsD CDS" gene 2471627..2472229 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /label="rpsD gene" downshifts 2472152 /Source="Nicolas_upshifts" /id="D1523" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="8.1141" /MaxDrop="2.9392" /score="31.6842" /energy="-13.6" /TU="U2297,U2299" /idTUdmin="U2297" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(2472207..2472426) /Source="Nicolas_S_feature" /locus_tag="new_3036310_3036529_c" /HighExp="S5, Etha, S8, S6, S7, S4, BT, S3, M9-stat, B36" /AntisenseName="rpsD" /AntisenseCor="-0.59018291599064199" /AntisenseRegPval="-25.9" /CDS_PredictionProba="0.99997899999999995" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1136" downshifts 2472215 /Source="Nicolas_upshifts" /id="D1524" /incds=0 /nref=135 /ntot=252 /MaxReadThrough="5.6866" /MaxDrop="6.10502" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=19 /isTUend="TRUE" /label="downshifts" downshifts complement(2472250) /Source="Nicolas_upshifts" /id="D1525" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="4.84346" /MaxDrop="3.28594" /score="-4.07107651" /energy="-10.8" /TU="U2300" /idTUdmin="U2301" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2472262 /Source="Nicolas_upshifts" /id="D1526" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="5.7799" /MaxDrop="4.26349" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2472307..2472480 /Source="Nicolas_S_feature" /locus_tag="new_3036410_3036583" /HighExp="LBGtran, LoTm, C30, Cold, LBGexp, B60, dia15, B36, H2O2, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig=1 /label="S1137" promotor_-10 complement(2472422..2472440) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2472434) /Source="Nicolas_upshifts" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="upshifts" downshifts 2472438 /Source="Nicolas_upshifts" /id="D1527" /incds=0 /nref=7 /ntot=151 /MaxReadThrough="1.39547" /MaxDrop="6.12149" /score="26.4940291" /energy="-16.4" /TU="NA" /idTUdmin="U2299" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2472455..2472461) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2472500..2473768) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /EC_number="6.1.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12547201, 15879350, 1735721, 9098057" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12547201, 15879350, 1735721, 9098057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_390845.1" /db_xref="EnsemblGenomes-Gn:BSU29670" /db_xref="EnsemblGenomes-Tr:CAB14945" /db_xref="GOA:P22326" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024107" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10371" /db_xref="UniProtKB/Swiss-Prot:P22326" /translation="MTNLLEDLSFRGLIQQMTDEEGLNKQLNEEKIRLYSGFDPTADS LHIGHLLPILTLRRFQLAGHHPIALVGGATGLIGDPSGKKAERTLNTADIVSEWSQKI KNQLSRFLDFEAAENPAVIANNFDWIGKMNVIDFLRDVGKNFGINYMLAKDTVSSRIE SGISYTEFSYMILQSYDFLNLYRDKNCKLQIGGSDQWGNITAGLELIRKSEEEGAKAF GLTIPLVTKADGTKFGKTEGGAIWLDKEKTSPYEFYQFWINTDDRDVVKYLKYFTFLS KEEIEAYAEKTETAPEKREAQKRLAEEVTSLVHGREALEQAINISQALFSGNIKELSA QDVKVGFKDVPSMEVDSTQELSLVDVLVQSKLSPSKRQAREDIQNGAVYINGERQTEI NYTLSGEDRIENQFTVLRRGKKKYFLVTYK*" /label="tyrS CDS" gene complement(2472500..2473768) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /label="tyrS gene" downshifts complement(2472526) /Source="Nicolas_upshifts" /id="D1528" /incds=0 /nref=110 /ntot=357 /MaxReadThrough="2.2673" /MaxDrop="6.847" /score="22.5238672" /energy="-16.4" /TU="NA" /idTUdmin="U2301" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" misc_RNA complement(2473792..2474065) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /product="T-Box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 10943892, 1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 10943892, 1317842, 9098041, 12165569, 12547201; Product type n : RNA" /function="16.3: Control" /label="tboY RNA" gene complement(2473792..2474065) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /label="tboY gene" S_feature complement(2473813..2473956) /Source="Nicolas_S_feature" /locus_tag="new_3037916_3038059_c" /HighExp="B60, Sw, B36, BC, M9-stat, T1.30H, S4, T4.0H, T2.30H, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40126600000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1138" downshifts complement(2473856) /Source="Nicolas_upshifts" /id="D1529" /incds=0 /nref=58 /ntot=127 /MaxReadThrough="6.75235" /MaxDrop="6.49727" /score="45.7279775" /energy="-17.7" /TU="U2301,U2303" /idTUdmin="U2301" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2474063..2474082) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2474075) /Source="Nicolas_upshifts" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2474095..2474102) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2474110..2475828) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /EC_number="6.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7934817, 10986270, 11255012, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10986270, 11255012, 16855235, 18487328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA synthetase" /protein_id="NP_390846.1" /db_xref="EnsemblGenomes-Gn:BSU29680" /db_xref="EnsemblGenomes-Tr:CAB14946" /db_xref="GOA:P39062" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG10370" /db_xref="UniProtKB/Swiss-Prot:P39062" /translation="MNLKALPAIEGDHNLKNYEETYRHFDWAEAEKHFSWHETGKLNA AYEAIDRHAESFRKNKVALYYKDAKRDEKYTFKEMKEESNRAGNVLRRYGNVEKGDRV FIFMPRSPELYFIMLGAIKIGAIAGPLFEAFMEGAVKDRLENSEAKVVVTTPELLERI PVDKLPHLQHVFVVGGEAESGTNIINYDEAAKQESTRLDIEWMDKKDGFLLHYTSGST GTPKGVLHVHEAMIQQYQTGKWVLDLKEEDIYWCTADPGWVTGTVYGIFAPWLNGATN VIVGGRFSPESWYGTIEQLGVNVWYSAPTAFRMLMGAGDEMAAKYDLTSLRHVLSVGE PLNPEVIRWGHKVFNKRIHDTWWMTETGSQLICNYPCMDIKPGSMGKPIPGVEAAIVD NQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYESYFMPGGWYVSGDSAYMDEEGYF WFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIGKPDPVRGEIIKAFIALREG FEPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRSGKIMRRVLKAWELNLPAGD LSTMED*" /label="acsA CDS" gene complement(2474110..2475828) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /label="acsA gene" promotor_-35 2475842..2475849 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2475856..2475875) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2475864..2475883 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2475870 /Source="Nicolas_upshifts" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2475879) /Source="Nicolas_upshifts" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2475889..2475895) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2475912..2475919 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2475933..2475952 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2475936 /Source="Nicolas_upshifts" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2475989..2476621 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein acetyltransferase (acetylates AcsA)" /protein_id="NP_390847.1" /db_xref="EnsemblGenomes-Gn:BSU29690" /db_xref="EnsemblGenomes-Tr:CAB14947" /db_xref="GOA:P39065" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR024699" /db_xref="SubtiList:BG10369" /db_xref="UniProtKB/Swiss-Prot:P39065" /translation="MEHHKTYHSANIKTATGSLLIEGPVSPEDLAGYEFHKDLTAFRP PREQHEALVDIAGLPEGRIIIARDGRTIVGYVTYLYPDPLERWSEGNMEDLIELGAIE VAPDYRGCAVGKTLLTVSMMDEQMENYIVMTTEYYWHWDLKGMKKDVWEYRKIMEKMM NAGGLVWFATDEPEISSHPANCLMARIGKNVSQESIEQFDRLRFYHRYMY*" /label="acuA CDS" gene 2475989..2476621 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /label="acuA gene" promotor_-35 2476194..2476202 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2476216..2476235 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2476222 /Source="Nicolas_upshifts" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2476648..2477292 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type f : factor" /codon_start=1 /transl_table=11 /product="component of the acetyl-coenzyme A synthetase regulation pathway" /protein_id="NP_390848.1" /db_xref="EnsemblGenomes-Gn:BSU29700" /db_xref="EnsemblGenomes-Tr:CAB14948" /db_xref="GOA:P39066" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG10368" /db_xref="UniProtKB/Swiss-Prot:P39066" /translation="MIVEQIMKRDVITLTKTDTLETAICKLKEFHIRHLPVVDEERHV IGMITDRDMKQASPSIFEENKRSLFLTRSVDSIMKKDVVCAHPLDFVEEISAVFYEHG IGCLPVVHHQKLIGILTKTDLLRTFVKLTGADQPGSQIEIKVNDITKSLAEISSLCQD LQVKILSVLVYPHDDPGVKVLVFRVKTMNPLPFLQALQRNGHHVVWPSEQRDLL*" /label="acuB CDS" gene 2476648..2477292 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /label="acuB gene" CDS 2477289..2478452 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein deacetylase (regulates AcsA activity)" /protein_id="NP_390849.1" /db_xref="EnsemblGenomes-Gn:BSU29710" /db_xref="EnsemblGenomes-Tr:CAB14949" /db_xref="GOA:P39067" /db_xref="InterPro:IPR000286" /db_xref="InterPro:IPR003085" /db_xref="InterPro:IPR023696" /db_xref="InterPro:IPR023801" /db_xref="InterPro:IPR037138" /db_xref="SubtiList:BG10367" /db_xref="UniProtKB/Swiss-Prot:P39067" /translation="MRDSVFIYSPSYQTYMFHQEHPFNQQRVLLTYDLLKTINAFDDG DIVTPRLASEEELSLVHTDDYIQAVKLAGAGKLPAEEGESYGLGTEDTPVFAGMHEAA SLLVGGTLTAADWVMSGQALHAANLGGGLHHGFRGRASGFCIYNDSAVAIQYIQKKYS ARVLYIDTDAHHGDGVQFTFYDNPDVCTLSIHETGRYLFPGTGQIQEKGSGKGYGYSF NIPLDAFTEDDSFLEAYRTAASEVAAYFEPDVIISQNGADAHYYDPLTHLSATINIYE EIPRLAHTLAHQYCGGKWIAVGGGGYDIWRVVPRAWARIWLEMKGIDPGHEIPPEWIV KWQKQCPVALPSSWSDPADLYPPIPRKPEITEKNAQTVSKALYAIRSEQQRTK*" /label="acuC CDS" gene 2477289..2478452 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /label="acuC gene" downshifts 2478443 /Source="Nicolas_upshifts" /id="D1530" /incds=0 /nref=98 /ntot=231 /MaxReadThrough="0.530530000000001" /MaxDrop="6.5095" /score="10.9528437" /energy="-9.1" /TU="NA" /idTUdmin="U2304" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2478463..2479191) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator peptidoglycan binding subunit of flagellar rotation" /protein_id="NP_390850.1" /db_xref="EnsemblGenomes-Gn:BSU29720" /db_xref="EnsemblGenomes-Tr:CAB14950" /db_xref="GOA:P39064" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10366" /db_xref="UniProtKB/Swiss-Prot:P39064" /translation="MKLRRERFERRNGSGKNSQSSSSWMVTFTDLITLILVFFILLFS MSQIDLQKFKAAVDSIQKEGNGLQPDQTSIEKKNTSPSDTKKQEDQQDQLLKKVNTYI KDNHLKAQMTAKRDERGVVLVLQEAVLFDTGEAKVLKNAETLLHQIAVLLQTIPNDIQ VEGHTDSRNISTYRYPSNWELSAARASGVIQYFTSKEKLPSKRFIAVGYADTKPVKDN KTNEHMKENRRVEIVIKKSKTTSS*" /label="motS CDS" gene complement(2478463..2479191) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /label="motS gene" downshifts complement(2478499) /Source="Nicolas_upshifts" /id="D1531" /incds=0 /nref=37 /ntot=149 /MaxReadThrough="1.3853" /MaxDrop="3.98206" /score="4.77211813" /energy="-6.9" /TU="NA" /idTUdmin="U2307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2479181..2479999) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator subunit offlagellar rotation" /protein_id="NP_390851.1" /db_xref="EnsemblGenomes-Gn:BSU29730" /db_xref="EnsemblGenomes-Tr:CAB14951" /db_xref="GOA:P39063" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10365" /db_xref="UniProtKB/Swiss-Prot:P39063" /translation="MKRFDYLTPVGFVLGTIIIVIGIISGSGVSGFRSFLDLTSFFIV TGGLCAAVFISFPPSELKKAPSVLKQAFIRQEDNVKDLVKTFVSLSDHARKHGLLSLD DQAREIKDPFLKKGLLLAIDGWDEETIRLVMDSEIAAMEERHRKGRRVFEKAGEFAPA WGMIGTLVGLVLMLKNLNDPHMLGPNMAIALLTTLYGSLLANMVFNPIAAKLEEKTES EIFIKQVMVEGIIGVQSGKNPRNLESQLVVFSSREEWQKQPKQVKTKKGSVHEA*" /label="motP CDS" gene complement(2479181..2479999) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /label="motP gene" CDS complement(2480062..2481066) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catabolite repression (Lacl family)" /protein_id="NP_390852.1" /db_xref="EnsemblGenomes-Gn:BSU29740" /db_xref="EnsemblGenomes-Tr:CAB14952" /db_xref="GOA:P25144" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR006377" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="PDB:1ZVV" /db_xref="PDB:2FEP" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10376" /db_xref="UniProtKB/Swiss-Prot:P25144" /translation="MSNITIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIER LGYRPNAVARGLASKKTTTVGVIIPDISSIFYSELARGIEDIATMYKYNIILSNSDQN MEKELHLLNTMLGKQVDGIVFMGGNITDEHVAEFKRSPVPIVLAASVEEQEETPSVAI DYEQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEANLPFNEQFVA EGDYTYDSGLEALQHLMSLDKKPTAILSATDEMALGIIHAAQDQGLSIPEDLDIIGFD NTRLSLMVRPQLSTVVQPTYDIGAVAMRLLTKLMNKEPVEEHIVELPHRIELRKSTKS *" /label="ccpA CDS" gene complement(2480062..2481066) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /label="ccpA gene" downshifts complement(2480079) /Source="Nicolas_upshifts" /id="D1532" /incds=0 /nref=62 /ntot=239 /MaxReadThrough="4.60553" /MaxDrop="4.6531" /score="5.3377823" /energy="-13.2" /TU="U2307,U2308,U2309" /idTUdmin="U2306" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(2481101..2481120) /Source="Nicolas_upshift_promotors" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2481116) /Source="Nicolas_upshifts" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2481118..2481226) /Source="Nicolas_S_feature" /locus_tag="new_3045221_3045329_c" /HighExp="Oxctl, H2O2, Paraq, MG-0.1, MG-0.2, G150, GM 15, Diami, LBGexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigB" /TUshortPSig="0.988, 1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1139" promotor_-10 complement(2481226..2481245) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2481226) /Source="Nicolas_upshifts" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2481228..2481293) /Source="Nicolas_S_feature" /locus_tag="new_3045331_3045396_c" /HighExp="BMM, GM 120, Diami, GM 90, M/G, GM 25, M9-exp, HiTm, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1140" promotor_-35 complement(2481259..2481265) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2481339) /Source="Nicolas_upshifts" /id="D1533" /incds=0 /nref=66 /ntot=188 /MaxReadThrough="6.10221" /MaxDrop="6.29667" /score="46.0872381" /energy="-11.3" /TU="U2308,U2309,U2310" /idTUdmin="U2311" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2481342..2482418) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /EC_number="2.5.1.54" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4200844, 7496534, 11444986, 16339761, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4200844, 7496534, 11444986, 16339761, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional chorismate mutase type II-isozyme 3(regulatory domain); 3-deoxy-D-arabino-heptulosonate7-phosphate synthase" /protein_id="NP_390853.1" /db_xref="EnsemblGenomes-Gn:BSU29750" /db_xref="EnsemblGenomes-Tr:CAB14953" /db_xref="GOA:P39912" /db_xref="InterPro:IPR002701" /db_xref="InterPro:IPR006218" /db_xref="InterPro:IPR006268" /db_xref="InterPro:IPR010954" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036979" /db_xref="PDB:5GMU" /db_xref="PDB:5GO2" /db_xref="SubtiList:BG10375" /db_xref="UniProtKB/Swiss-Prot:P39912" /translation="MSNTELELLRQKADELNLQILKLINERGNVVKEIGKAKEAQGVN RFDPVRERTMLNNIIENNDGPFENSTIQHIFKEIFKAGLELQEEDHSKALLVSRKKKP EDTIVDIKGEKIGDGQQRFIVGPCAVESYEQVAEVAAAAKKQGIKILRGGAFKPRTSP YDFQGLGVEGLQILKRVADEFDLAVISEIVTPAHIEEALDYIDVIQIGARNMQNFELL KAAGAVKKPVLLKRGLAATISEFINAAEYIMSQGNDQIILCERGIRTYETATRNTLDI SAVPILKQETHLPVFVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPSVALSDS AQQMAIPEFEKWLNELKPMVKVNA*" /label="aroX CDS" gene complement(2481342..2482418) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /label="aroX gene" promotor_-10 complement(2482459..2482478) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-10" upshifts complement(2482479) /Source="Nicolas_upshifts" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="upshifts" S_feature complement(2482481..2482581) /Source="Nicolas_S_feature" /locus_tag="new_3046584_3046684_c" /HighExp="Lbtran, BMM, dia5, GM 25, GM 90, M9-exp, MG 150, Diami, MG-0.2, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigH" /TUshortPSig="0.974, 1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1141" promotor_-35 complement(2482493..2482500) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-35" downshifts 2482515 /Source="Nicolas_upshifts" /id="D1534" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.07872" /MaxDrop="3.23284" /score="1.10447256" /energy="-7.6" /TU="NA" /idTUdmin="U2304" /TUdmin=4071 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2482569..2482588) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2482581) /Source="Nicolas_upshifts" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2482602..2482608) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2482654..2482980) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22938038, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22938038, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin involved in debacillithiolation" /protein_id="NP_390854.1" /db_xref="EnsemblGenomes-Gn:BSU29760" /db_xref="EnsemblGenomes-Tr:CAB14954" /db_xref="InterPro:IPR022551" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10373" /db_xref="UniProtKB/Swiss-Prot:P39914" /translation="MAKQLIQSEEEFKRIAEQEGVFVFLKHSTTCPISQAAFHEFDAF ANQHEDVPAYYLQVQEARPLSNFIAETYGVKHESPQIFIIQNGEVKWHTSHSQITEAA IEQHLS*" /label="brxJ CDS" gene complement(2482654..2482980) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /label="brxJ gene" downshifts complement(2482663) /Source="Nicolas_upshifts" /id="D1535" /incds=0 /nref=144 /ntot=286 /MaxReadThrough="7.09736" /MaxDrop="5.96753" /score="13.8032115" /energy="-7.6" /TU="U2310,U2311" /idTUdmin="U2313" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2483004..2483459) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8733232, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390855.2" /db_xref="EnsemblGenomes-Gn:BSU29770" /db_xref="EnsemblGenomes-Tr:CAB14955" /db_xref="InterPro:IPR024623" /db_xref="SubtiList:BG10975" /db_xref="UniProtKB/Swiss-Prot:P40780" /translation="MSKDGINSKDFLIGTLIGGIIGATTALFLAPKSGKELRDDLGSQ AVALRDKTDKMTADAKEKGTQYVSIAKDKTSNITQLVADQSGQIMNKVKDLRDRSKSD KTDSSTAMQDMREEAMQAADETKDQVLQTKEDVKDELKDAQKQAEQLNR*" /label="ytxH CDS" gene complement(2483004..2483459) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /label="ytxH gene" CDS complement(2483490..2483912) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22720735, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein" /protein_id="NP_390856.2" /db_xref="EnsemblGenomes-Gn:BSU29780" /db_xref="EnsemblGenomes-Tr:CAB14956" /db_xref="GOA:P40779" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG10974" /db_xref="UniProtKB/Swiss-Prot:P40779" /translation="MIIILYLSVALIAVAFLVLVIYLSKTLKSLQLTLKNVASTLEGL EGQMKGITTETAELLHKTNRLAEDIQEKSEKLNTVVHAVQGVGASVQQFNTSMKQAAG SVSASVRENQDKINQVVTWSQAAMEIWEKWKQKKKSAL*" /label="ytxG CDS" gene complement(2483490..2483912) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /label="ytxG gene" promotor_-10 complement(2483933..2483951) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2483946) /Source="Nicolas_upshifts" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2483965..2483971) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2483985..2484003) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-10" upshifts complement(2483994) /Source="Nicolas_upshifts" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="upshifts" promotor_-35 complement(2484014..2484022) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-35" CDS complement(2484074..2485372) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /EC_number="6.3.2.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10565540, 12682299, 12781748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetyl muramate-alanine ligase" /protein_id="NP_390857.1" /db_xref="EnsemblGenomes-Gn:BSU29790" /db_xref="EnsemblGenomes-Tr:CAB14957" /db_xref="GOA:P40778" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005758" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10973" /db_xref="UniProtKB/Swiss-Prot:P40778" /translation="MTVYHFVGIKGTGMSPLAQILHDNGYTVQGSDIEKFIFTQTALE KRNITILPFSAENIKPGMTVIAGNAFPDTHPEIEKAMSEGIPVIRYHKFLGDYMKKFT SVAVTGAHGKTSTTGLLAHVIQNAKPTSFLIGDGTGQGNENSEYFVFEACEYRRHFLS YQPDYAIMTNIDFDHPDYFSSIDDVFDAFQEMALQVNKGIIACGDDEHLPKIHANVPV VYYGTGEENDFQARNIVKSTEGTTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCH YEEIDSSIIKHALKSFGGVKRRFNEKQLGDQVLIDDYAHHPTEIKVTIEAARQKYPDR EIVAVFQPHTFTRTQQFLDEFAESLSGADCVYLCDIFGSARENAGKLTIGDLQGKIHN AKLIEEDDTSVLKAHDKAVLIFMGAGDIQKYMRAYENVMA*" /label="murC CDS" gene complement(2484074..2485372) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /label="murC gene" downshifts complement(2484083) /Source="Nicolas_upshifts" /id="D1536" /incds=0 /nref=29 /ntot=180 /MaxReadThrough="5.23049" /MaxDrop="5.42617" /score="15.3729968" /energy="-7.5" /TU="U2313,U2314" /idTUdmin="U2312" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2485397..2485416) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2485398) /Source="Nicolas_upshifts" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2485400..2485596) /Source="Nicolas_S_feature" /locus_tag="new_3049503_3049699_c" /HighExp="Cold, G150, G135, dia15, G180, H2O2, C30, Oxctl, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.938" /label="S1142" promotor_-35 complement(2485429..2485438) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2485579..2485598) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2485596) /Source="Nicolas_upshifts" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2485610..2485616) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2485622..2488480) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /function="8.1: DNA replication, recombination, and repair" /experiment="publication(s) with functional evidences, PMID:3129532, 11134515, 11208805, 19788545, 28110333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3129532, 11134515, 11208805, 19788545, 28110333; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="DNA translocase" /protein_id="NP_390859.2" /db_xref="EnsemblGenomes-Gn:BSU29805" /db_xref="EnsemblGenomes-Tr:CAB14959" /db_xref="GOA:C0SP86" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13906" /db_xref="UniProtKB/Swiss-Prot:C0SP86" /translation="MSWLHKFFDLFLGESEEDAERETKPAQIPQQQEVHHPEGQLKRL EDPKIYYEYPKGKFRFPVVPDGYKNHDLRRRRTPSDEPKSAPRPSAAPYRERPRNEEE QHTYQAAEPAKKPFKPTNIPSPVYGFNQKPSVKKDVPKKPSETLNEPDKSVKEKVTLL SEEIERERGYPASDTQAHSKIESPFFPDTQFEKQPSGVLNRKDTEHDEALAKRPAEPS GNKVPFESGVQQPEKEEPFFPAEQAEEQTPPEMLTDTAAEGLSDSEVGREEPATAEEE QREQQPEKFEEPVFSAELDEEQTAPESQTEAVSEDEKAKEPSDSPVYNHHENAAEGAE SPFVQEEQMDIRQEEPLFTDHEYSSEALAQAETVAKESEEPSESIINNHYDTLGEAQE TKIDVQPDSHTELEKTEHMEQGSKSSTATLENRQEIRADKPREASEEPKKRPGVQEKR TEQSASSQKGPSVPFNVMMLKRDTHKQQKAEERRGSYVFPNVALLDVPPAQVQDDTAW IEEQRQLLDLTLKNFNVRANVVHVTQGPSVTRFEVHPEPGVKVNKITNLSDDIKLSLS AKDIRIEAPIPGKNTIGIEVPNRTSKVVDLRQMIRSSAFRTSKSPLTAALGLDISGNP VVIDLKKMPHGLIAGATGSGKSVCINTILVSLLYKADPSEVKVLLIDPKMVELAPYNK IPHLVSPVITDAKAATAALKWVVEEMERRYELFAHSGVRDIDRFNQLTAEHQMGEKLP YLVVIIDELADLMMVAPNDVEESIARIAQKARACGIHLLVATQRPSVDVITGLIKANI PTRIAFSVSSQVDSRTIIDIAGAEKLLGKGDMLFLENGSGKPVRLQGNFVSDREIDRV VSHVRSQMPPTYLFEQEELVRQGSALKEEDELFYEACEFVVEQNSASTSSLQRRFRIG YNRAARLIDMMEAEGMISEAKGSKPREVLITASDLINE*" /label="sftA CDS" gene complement(2485622..2488480) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /label="sftA gene" promotor_-10 complement(2488514..2488533) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-10" upshifts complement(2488524) /Source="Nicolas_upshifts" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="upshifts" promotor_-35 complement(2488549..2488553) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-35" downshifts complement(2488623) /Source="Nicolas_upshifts" /id="D1537" /incds=0 /nref=186 /ntot=249 /MaxReadThrough="4.47299" /MaxDrop="6.35097" /score="9.62039509" /energy="-14.5" /TU="U2315" /idTUdmin="U2315" /TUdmin="-1553" /isTUend="FALSE" /label="downshifts" CDS complement(2488640..2489245) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21949854, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA binding enzyme" /protein_id="NP_390860.1" /db_xref="EnsemblGenomes-Gn:BSU29820" /db_xref="EnsemblGenomes-Tr:CAB14960" /db_xref="GOA:O34943" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027855" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR037154" /db_xref="SubtiList:BG13905" /db_xref="UniProtKB/Swiss-Prot:O34943" /translation="MNAFYNKEGVGDTLLISLQDVTREQLGYEKHGDVVKIFNNETKE TTGFNIFNASSYLTIDENGPVALSETFVQDVNEILNRNGVEETLVVDLSPKFVVGYVE SKEKHPNADKLSVCKVNVGEETLQIVCGAPNVDQGQKVVVAKVGAVMPSGLVIKDAEL RGVPSSGMICSAKELDLPDAPAEKGILVLEGDYEAGDAFQF*" /label="ytpR CDS" gene complement(2488640..2489245) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /label="ytpR gene" CDS complement(2489261..2490070) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12719520, 21949854" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (iron homeostasis)" /protein_id="NP_390861.1" /db_xref="EnsemblGenomes-Gn:BSU29830" /db_xref="EnsemblGenomes-Tr:CAB14961" /db_xref="InterPro:IPR010838" /db_xref="SubtiList:BG13904" /db_xref="UniProtKB/Swiss-Prot:O34496" /translation="MKMTSRKLSDILKQRLQHENRSFLFDREKDTLRVEDQTTKKGIT LDLPPIIAKWELKKDEAIDEIVYYVSEAMTAMEGKAQEMTGKETRIYPVIRSTSFPDK SSEDIPLIYDDHTAETRIYYALDLGKTYRLIDQRMLEKENWTKERIRETAAFNLRSLP TVVKEDTVAGNYFYFFRANDGYDASRILNEAILNEYKQHAEGELAISVPHQDVLILAD IRNESGYDILGQMSMSFFAGGTVPITALSFLYNEGKLEPVFILAKSRPKKD*" /label="ytpQ CDS" gene complement(2489261..2490070) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /label="ytpQ gene" CDS complement(2490085..2490408) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12719520, 15937154, 21949854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_390862.1" /db_xref="EnsemblGenomes-Gn:BSU29840" /db_xref="EnsemblGenomes-Tr:CAB14962" /db_xref="GOA:O34357" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13903" /db_xref="UniProtKB/Swiss-Prot:O34357" /translation="MKKIESTQELEKAVKDDWSVFMFSADWCPDCRFVEPFLPELEAN FPEFTYYYVDRDKFIDTCAEWEIYGIPSFVVFNEGKEVNRFVSKDRKTKEEIEQFLTD SLAKA*" /label="ytpP CDS" gene complement(2490085..2490408) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /label="ytpP gene" S_feature complement(2490409..2490547) /Source="Nicolas_S_feature" /locus_tag="new_3054512_3054650_c" /HighExp="G180, G150, Paraq, Oxctl, H2O2, Diami, C90, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.32150299999999998" /TUshortSig="SigA" /TUshortPSig="0.938" /TUlongSig="NA" /TUlongPSig="NA" /label="S1143" CDS complement(2490447..2490563) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513998.1" /translation="MQIKYDNDNGKANLTYSFVAYKWFCLKQFGMIQMDEYR*" /label="hypothetical protein CDS" gene complement(2490447..2490563) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /label="gene" promotor_-10 complement(2490534..2490553) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-10" upshifts complement(2490547) /Source="Nicolas_upshifts" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="upshifts" promotor_-35 2490555..2490562 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2490577..2490596 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2490582 /Source="Nicolas_upshifts" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="upshifts" CDS 2490643..2491089 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with sugar binding fold" /protein_id="NP_390863.1" /db_xref="EnsemblGenomes-Gn:BSU29850" /db_xref="EnsemblGenomes-Tr:CAB14963" /db_xref="InterPro:IPR019884" /db_xref="SubtiList:BG13899" /db_xref="UniProtKB/Swiss-Prot:O34305" /translation="MEFIVYLAGEIHSNWREEIKEKTKSLKLPITFVGPMENHDRSDN IGEEIMGVQPNAVLKDDKASDINNFRTAVLMNKADFVIALFGEKYKQWNTAMDASYAI AKGKPLIIIRPESLHHPLKELSNKANITVETVNQAIKALSYLFETE*" /label="ytoQ CDS" gene 2490643..2491089 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /label="ytoQ gene" S_feature 2491090..2491818 /Source="Nicolas_S_feature" /locus_tag="new_3055193_3055921" /HighExp="H2O2, dia15, C30, C90, Diami, S1, M0t45, Salt, Paraq, Lbexp" /AntisenseName="ytoP" /AntisenseCor="0.35418735783791" /AntisenseRegPval="-8.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.981" /TUlongSig="NA" /TUlongPSig="NA" /label="S1144" CDS complement(2491144..2492217) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8535515; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative modified amino acid aminopeptidase" /protein_id="NP_390864.1" /db_xref="EnsemblGenomes-Gn:BSU29860" /db_xref="EnsemblGenomes-Tr:CAB14964" /db_xref="GOA:O34924" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13898" /db_xref="UniProtKB/Swiss-Prot:O34924" /translation="MNQETKALFQTLTQLPGAPGNEHQVRAFMKQELAKYADDIVQDR LGSVFGVRRGAEDAPRIMVAGHMDEVGFMVTSITDNGLLRFQTLGGWWSQVLLAQRVE IQTDNGPVPGVISSIPPHLLTDAQRNRPMDIKNMMIDIGADDKEDAIKIGIRPGQQIV PVCPFTTMANEKKILSKAWDNRYGCGLSIELLKELHGKELPNTLYAGATVQEEVGLRG AQTASHMIKPDLFFALDASPANDMSGDKNEFGQLGKGFLLRILDRTTVMHRGMREFVL DMAETHDIPYQYFVSGGGTDAGKVHISNSGVPSAVIGICSRYIHTNATIIHIDDYAAA KEMLIKLVTACDKQTVDAIKENM*" /label="ytoP CDS" gene complement(2491144..2492217) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /label="ytoP gene" downshifts complement(2491163) /Source="Nicolas_upshifts" /id="D1538" /incds=0 /nref=140 /ntot=248 /MaxReadThrough="1.89952" /MaxDrop="4.55096" /score="14.9571314" /energy="-14.4" /TU="NA" /idTUdmin="U2317" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2492239..2492258) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2492243) /Source="Nicolas_upshifts" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2492272..2492279) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2492314..2492317 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2492332..2492351 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2492337 /Source="Nicolas_upshifts" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="upshifts" CDS 2492376..2492693 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390865.1" /db_xref="EnsemblGenomes-Gn:BSU29870" /db_xref="EnsemblGenomes-Tr:CAB14965" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13936" /db_xref="UniProtKB/Swiss-Prot:O32065" /translation="MKLRHLLLGAGLGICTAVVVRQYVMKPYISSEKALRIVKSAFKQ RGPIDGSWIYTQPEPYNINGETVQVYKTGITRSAFGELEQYEVMVDAKTGEIVDVIDT IAS*" /label="ytzB CDS" gene 2492376..2492693 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /label="ytzB gene" downshifts 2492693 /Source="Nicolas_upshifts" /id="D1539" /incds=0 /nref=250 /ntot=259 /MaxReadThrough="1.29231" /MaxDrop="7.83082" /score="44.9062865" /energy="-17" /TU="NA" /idTUdmin="U2318" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2492746..2494446) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 20933603, 22740702, 23136871, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_390866.1" /db_xref="EnsemblGenomes-Gn:BSU29880" /db_xref="EnsemblGenomes-Tr:CAB14966" /db_xref="GOA:O34389" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG12614" /db_xref="UniProtKB/Swiss-Prot:O34389" /translation="MKQFRVTNEGDIQTTLRGLEVLSVPFLNKGVAFTEEERKELGLK GFLPPKVLTIDDQAKRAYEQYSAQPDDLSKNVYLTALHDRNETLFYRLLNDHLGEMLP IVYTPTVGTAIQRYSHEYRKPRGLYLSIDDPDGMKEAFKQYKDQSDTIDLIVATDAEG ILGIGDWGVGGIAISIGKLAVYTAAAGIDPSRVLAVVLDAGTNQESLLNDPLYVGNQH SRVRGERYDQFIDDYVALARETFPNALLHWEDFGAKNARSILKRYKDKVCTFNDDIQG TGAVSLAAVLSCAKASKVPLRDHRVVIFGAGTAGIGIAEQLREALVREGLSEEESYKR FWCIDRNGLLTDDMDQLLDFQKPYARSADEVKDYQRNGDGGGIDLLEVVRQAKPTILI GTSTVSGAFTEEIVKEMASHVKRPAILPMSNPTTLSEAKPEDLIEWTEGRALITTGSP FPPVEYNGVTYHIGQANNALVFPGLGLGTIVTKSKLITDGMFEACARAIAGMVNVGVP GAPMLPKVEDLRTVSATVAVEVAKTAMKEGVATEEPEDIIQAVQDAMWYPVYKPIRAI *" /label="maeC CDS" gene complement(2492746..2494446) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /label="maeC gene" downshifts complement(2492765) /Source="Nicolas_upshifts" /id="D1540" /incds=0 /nref=77 /ntot=255 /MaxReadThrough="2.4872" /MaxDrop="4.99085" /score="17.675308" /energy="-15.3" /TU="NA" /idTUdmin="U2319" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2494478..2494496) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2494485) /Source="Nicolas_upshifts" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2494511..2494517) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2494528..2495298) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22101040, 24268182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative quorum-quenching lactonase" /protein_id="NP_390867.1" /db_xref="EnsemblGenomes-Gn:BSU29890" /db_xref="EnsemblGenomes-Tr:CAB14967" /db_xref="GOA:O34760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13895" /db_xref="UniProtKB/Swiss-Prot:O34760" /translation="MFGVVPKPLWSKKYPVNEKNQIELRTDPILIQKDGLNIIIDAGI GYGKLTDKQKRNYGVTQESNVKPSLAALGLTVADIDVIAMTHLHFDHACGLTEYEGER LVSVFPNAVIYTSAVEWDEMRHPNIRSKNTYWKENWEAVAGQVKTFEDTLTITEGITM HHTGGHSDGHSVLICEDAGETAVHMADLMPTHAHRNPLWVLAYDDYPMTSIPQKQKWQ AFAAEKDAWFIFYHDAEYRALQWEEDGSIKKSVKRMKR*" /label="ytnP CDS" gene complement(2494528..2495298) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /label="ytnP gene" S_feature complement(2495299..2495387) /Source="Nicolas_S_feature" /locus_tag="new_3059402_3059490_c" /HighExp="HiOs, M40t90, T0.30H, T1.30H, T3.0H, T1.0H, Sw, T2.30H, T3.30H, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1145" promotor_-10 complement(2495385..2495404) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2495387) /Source="Nicolas_upshifts" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2495420..2495424) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2495444..2496085) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /EC_number="2.1.1.33" /function="16.6: Maintain" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15789416, 16600901, 17150909, 19934251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15789416, 16600901, 17150909, 19934251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (guanine-N(7)-)-methyltransferase" /protein_id="NP_390868.1" /db_xref="EnsemblGenomes-Gn:BSU29900" /db_xref="EnsemblGenomes-Tr:CAB14968" /db_xref="GOA:O34522" /db_xref="InterPro:IPR003358" /db_xref="InterPro:IPR029063" /db_xref="PDB:2FCA" /db_xref="SubtiList:BG13890" /db_xref="UniProtKB/Swiss-Prot:O34522" /translation="MRMRHKPWADDFLAENADIAISNPADYKGKWNTVFGNDNPIHIE VGTGKGQFISGMAKQNPDINYIGIELFKSVIVTAVQKVKDSEAQNVKLLNIDADTLTD VFEPGEVKRVYLNFSDPWPKKRHEKRRLTYSHFLKKYEEVMGKGGSIHFKTDNRGLFE YSLKSFSEYGLLLTYVSLDLHNSNLEGNIMTEYEEKFSALGQPIYRAEVEWRT*" /label="trmB CDS" gene complement(2495444..2496085) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /label="trmB gene" downshifts complement(2495454) /Source="Nicolas_upshifts" /id="D1541" /incds=0 /nref=46 /ntot=131 /MaxReadThrough="3.31031" /MaxDrop="5.64644" /score="29.2137061" /energy="-10.1" /TU="NA" /idTUdmin="U2321" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(2495519) /Source="Nicolas_upshifts" /id="D1542" /incds=1 /nref=39 /ntot=202 /MaxReadThrough="6.31908" /MaxDrop="3.64275" /score="29.2137061" /energy="-10.1" /TU="U2321,U2323" /idTUdmin="U2323" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2496111..2496130) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2496120) /Source="Nicolas_upshifts" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2496122..2496570) /Source="Nicolas_S_feature" /locus_tag="new_3060225_3060673_c" /HighExp="C30, Cold, G135, G180, B60, Paraq, G150, Oxctl, H2O2, LBGstat" /AntisenseName="ytzH" /AntisenseCor="-0.51149457663808795" /AntisenseRegPval="-18.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1146" promotor_-35 complement(2496146..2496150) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2496229..2496235 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2496250..2496261 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2496257 /Source="Nicolas_upshifts" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="upshifts" CDS 2496292..2496570 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390869.1" /db_xref="EnsemblGenomes-Gn:BSU29910" /db_xref="EnsemblGenomes-Tr:CAB14969" /db_xref="InterPro:IPR025547" /db_xref="SubtiList:BG13942" /db_xref="UniProtKB/Swiss-Prot:O32066" /translation="MGLHYEHQVHLLKDILTDHQLDCCGTVAEYEQLERVIKSLMANT ELDSNFKNVLEDVYRYSQSGISSKSIDSHIQEHQNSLSQWVEQMDSYS*" /label="ytzH CDS" gene 2496292..2496570 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /label="ytzH gene" S_feature 2496571..2496741 /Source="Nicolas_S_feature" /locus_tag="new_3060674_3060844" /HighExp="S5, S7, S8, S6, S4, BT, C30, nit, ferm, G/S" /AntisenseName="ytmP" /AntisenseCor="-0.32108027439793901" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1147" CDS complement(2496571..2497185) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9026440, 11545674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase/phosphotransferase" /protein_id="NP_390870.2" /db_xref="EnsemblGenomes-Gn:BSU29920" /db_xref="EnsemblGenomes-Tr:CAB14970" /db_xref="GOA:C0SPC1" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG13889" /db_xref="UniProtKB/Swiss-Prot:C0SPC1" /translation="MENGDVITAQHWMTGRELKPKDMSGRPVAELLRKIHTSKALLDM LKRLGKEPLNPGALLSQLKQAVFAVQQSSPLIQEGIKYLEEHLHEVHFGEKVVCHCDV NHNNWLLSEDNQLYLIDWDGAMIADPAMDLGPLLYHYVEKPAWESWLSMYGIELTESL RLRMAWYVLSETITFIAWHKAKGNDKEFHDAMEELHILMKRIVD*" /label="ytmP CDS" gene complement(2496571..2497185) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /label="ytmP gene" downshifts 2496719 /Source="Nicolas_upshifts" /id="D1543" /incds=1 /nref=4 /ntot=35 /MaxReadThrough="2.54837" /MaxDrop="3.82368" /score="-4.89809956" /energy="-11.3" /TU="NA" /idTUdmin="U2322" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2497186..2497521) /Source="Nicolas_S_feature" /locus_tag="new_3061289_3061624_c" /HighExp="T1.30H, M9-stat, T2.30H, T3.0H, UNK1, B60, T2.0H, T3.30H, T1.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1148" promotor_-10 complement(2497513..2497532) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2497521) /Source="Nicolas_upshifts" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2497547..2497554) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2497548..2499704) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /EC_number="3.2.1.41" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9453151, 16582490, 19465663, 23973973" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9453151, 16582490, 19465663, 23973973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pullulanase" /protein_id="NP_390871.2" /db_xref="EnsemblGenomes-Gn:BSU29930" /db_xref="EnsemblGenomes-Tr:CAB14971" /db_xref="GOA:C0SPA0" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR011840" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="PDB:2E8Y" /db_xref="PDB:2E8Z" /db_xref="PDB:2E9B" /db_xref="SubtiList:BG12566" /db_xref="UniProtKB/Swiss-Prot:C0SPA0" /translation="MVSIRRSFEAYVDDMNIITVLIPAEQKEIMTPPFRLETEITDFP LAVREEYSLEAKYKYVCVSDHPVTFGKIHCVRASSGHKTDLQIGAVIRTAAFDDEFYY DGELGAVYTADHTVFKVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDLH GYEYLFCICNNSEWMETVDQYAKAVTVNGEKGVVLRPDQMKWTAPLKPFSHPVDAVIY ETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVELLPVNDF AGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHGLRVIL DVVFNHVYKRENSPFEKTVPGYFFRHDECGMPSNGTGVGNDIASERRMARKFIADCVV YWLEEYNVDGFRFDLLGILDIDTVLYMKEKATKAKPGILLFGEGWDLATPLPHEQKAA LANAPRMPGIGFFNDMFRDAVKGNTFHLKATGFALGNGESAQAVMHGIAGSSGWKALA PIVPEPSQSINYVESHDNHTFWDKMSFALPQENDSRKRSRQRLAAAIILLAQGVPFIH SGQEFFRTKQGVENSYQSSDSINQLDWDRRETFKEDVHYIRRLISLRKAHPAFRLRSA ADIQRHLECLTLKEHLIAYRLYDLDEVDEWKDIIVIHHASPDSVEWRLPNDIPYRLLC DPSGFQEDPTEIKKTVAVNGIGTVILYLASDLKSFA*" /label="amyX CDS" gene complement(2497548..2499704) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /label="amyX gene" Polymorphism join(2499245,2499247) /Source="geneious" /ID="SNP_BsDelta6_3063349_3063349" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=459 /Change="A -> G" /Codon_Change="GTT -> GTC" /Coverage=168 /locus_tag="BSU_29930" /Protein_Effect="None" /Reference_Frequency="1.2%" /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=165 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2499730..2500659) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /EC_number="2.7.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospholipid kinase" /protein_id="NP_390872.1" /db_xref="EnsemblGenomes-Gn:BSU29940" /db_xref="EnsemblGenomes-Tr:CAB14972" /db_xref="GOA:O34799" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13880" /db_xref="UniProtKB/Swiss-Prot:O34799" /translation="MSHWFFIINPTAGHRNGLRVWKSIQKELIKRKVEHRSFLTEHPG HAEVLARQISTIQEYKLKRLIVIGGDGTMHEVVNGLKDVDDIELSFVPAGAYNDFSRG FSIKKIDLIQEIKKVKRPLTRTFHLGSVNFLQDKSQILYFMNHIGIGFDAYVNKKAME FPLRRVFLFLRLRFLVYPLSHLHASATFKPFTLACTTEDETREFHDVWFAVVSNHPFY GGGMKAAPLANPREKTFDIVIVENQPFLKKYWLLCLMAFGKHTKMDGVTMFKAKDITF YTKDKIPFHADGEIMGTTPFRLASSPSPLRIKT*" /label="ytlR CDS" gene complement(2499730..2500659) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /label="ytlR gene" CDS complement(2500708..2501622) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390873.1" /db_xref="EnsemblGenomes-Gn:BSU29950" /db_xref="EnsemblGenomes-Tr:CAB14973" /db_xref="InterPro:IPR012397" /db_xref="SubtiList:BG13879" /db_xref="UniProtKB/Swiss-Prot:O34471" /translation="MAQIIKIHDYISRYELDPYHYINQFVRLKKERWLSLVEAAERQH EERQASAEEPEPVQKRKKFSLKRRKEEIKADIQEERHQWFEDEEDIHVRLPKSRVALA SFYKRHLYDFQLKWASSTLSEISQLSNQVKQDRILRYLTQQLPDSYFIMYKPVLKIQQ AAVELSIVIISPLEIYCVSFLEAEEDSVYIGSKNRFWDKKTASQTASVLNPGLSLFRT DSVVSKIVKEKQAEIPVRKLLLSRTSYIDYPEPPYGLEIADKRSAEEWIERQKKNTAP IKHHQVKAAKALLSYCMSDSYRRQEWLE*" /label="ytlQ CDS" gene complement(2500708..2501622) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /label="ytlQ gene" promotor_-10 complement(2501385..2501403) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2501393) /Source="Nicolas_upshifts" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2501417..2501423) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" CDS complement(2501648..2502199) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /EC_number="3.1.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17012785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA 2',3'-cyclic phosphodiesterase" /protein_id="NP_390874.1" /db_xref="EnsemblGenomes-Gn:BSU29960" /db_xref="EnsemblGenomes-Tr:CAB14974" /db_xref="GOA:O34570" /db_xref="InterPro:IPR004175" /db_xref="InterPro:IPR009097" /db_xref="SubtiList:BG13878" /db_xref="UniProtKB/Swiss-Prot:O34570" /translation="MPDIRPHYFIGVPIPEGIANPIYQAAKNEPILTFQKWVHPLDYH ITLIFLGAADETQIKKLEGSLAEIASEIDPFSIKFGKIDVFGDRRKPRVLHLEPKKNK TLDRLREHTKQAVLQAGFQVEKRPYHPHMTLARKWTGEDGFPAHVPFESGEVSMMAER FSLFQIHLNQSPKYEEIFKFQLS*" /label="ytlP CDS" gene complement(2501648..2502199) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /label="ytlP gene" misc_feature 2502062..2502081 /Source="Nicolas_upshift_promotors" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2502065 /Source="Nicolas_upshifts" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2502222..2502241) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2502234) /Source="Nicolas_upshifts" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2502257..2502260) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" promotor_-35 2502282..2502289 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2502300..2502319 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2502303..2502314) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2502307 /Source="Nicolas_upshifts" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2502317) /Source="Nicolas_upshifts" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2502328..2502334) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2502348..2503283 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cysteine synthase-like enzyme" /protein_id="NP_390875.1" /db_xref="EnsemblGenomes-Gn:BSU29970" /db_xref="EnsemblGenomes-Tr:CAB14975" /db_xref="GOA:O34476" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG13872" /db_xref="UniProtKB/Swiss-Prot:O34476" /translation="MLKIVANTADLIGDTPLVRLNRLQPENAAQVYLKLEFFNPSGSV KDRAAYQMIIEAEQNGLLKPGSVIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKE RINLLKAYGAEVVLTPGEERMPGSIKKAKELAEQIPNSYIPMQFDNTANPDAHRKTTA PEIARAIEEIGKPLGAFVASSGTGGTITGTGEALKELFPDITVHVVEPAGSPVLSGGK PGAHKLVGTSPGFIPPILNEDVYDEIIKISDEDAYTTTRRLAAEEGILVGPSSGAACF AAIETAKRLSPDKVVVCMTADTGERYLSTDLWSFI*" /label="ytkP CDS" gene 2502348..2503283 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /label="ytkP gene" downshifts 2503259 /Source="Nicolas_upshifts" /id="D1544" /incds=0 /nref=74 /ntot=225 /MaxReadThrough="2.5873" /MaxDrop="4.59197" /score="29.2734118" /energy="-18.2" /TU="NA" /idTUdmin="U2327" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(2503317..2504708) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /EC_number="3.5.-.-" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7528082, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative promiscuous peptidase/deacylase" /protein_id="NP_390876.1" /db_xref="EnsemblGenomes-Gn:BSU29980" /db_xref="EnsemblGenomes-Tr:CAB14976" /db_xref="GOA:O34944" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010964" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13867" /db_xref="UniProtKB/Swiss-Prot:O34944" /translation="MNWEVEVIRKKEDLIRDTQEFLRINSVMDETTAGPGKPFGEGVN ASLTSLLELGEKEGFTTKNLDGFAGHIEWGEGDDIIGVLCHVDVVPPGDGWTSDPFSA EIRNGRIYARGAIDDKGPTMAAFYALKIVKDMNLPLSKRVRMIIGTDEESDWRCVEHY FKHEEMPTMGFAPDADFPIINAEKGIIDASLLIPHRPNQAEPKAVLVSFQSGLRLNMV PDAAEAVIEGPKNEEILSSFKDMLRTTDQKGEAAIENGQLILRMYGLSCHAMEPNNGI NAGILLCEFLQQTELDDAGKRFVQVVTDKFSGDTRGKKLDIDCEDEISGELTLNVGTL RYKEGQGGELGINIRYPVTAESKVIRDTFESASEFELGEFKDSKPHHVSADHPLVKTL QKVYEGQLGKKADLISIGGGTYARSLKAGVAFGPLFPGRPDSAHQKDEYIEIDDLLRS TALYAQAIYELAK*" /label="ytjP CDS" gene complement(2503317..2504708) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /label="ytjP gene" downshifts complement(2503329) /Source="Nicolas_upshifts" /id="D1545" /incds=0 /nref=63 /ntot=240 /MaxReadThrough="3.38616" /MaxDrop="3.73023" /score="23.9099234" /energy="-14.4" /TU="U2330" /idTUdmin="U2330" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature complement(2504709..2505149) /Source="Nicolas_S_feature" /locus_tag="new_3068812_3069252_c" /HighExp="Etha, Salt, M40t90, Lbtran, T1.30H, M0t90, Lbstat, T1.0H, T0.30H, LBGstat" /AntisenseName="pbuO" /AntisenseCor="-0.324692399913451" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1149" promotor_-35 2504735..2504740 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2504754..2504773 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2504767 /Source="Nicolas_upshifts" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="upshifts" CDS 2504805..2506103 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11591660, 12923093, 15849754, 16850406, 19446032, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12923093, 15849754, 16850406, 19446032, 28583948; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_390877.1" /db_xref="EnsemblGenomes-Gn:BSU29990" /db_xref="EnsemblGenomes-Tr:CAB14977" /db_xref="GOA:O34978" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG13864" /db_xref="UniProtKB/Swiss-Prot:O34978" /translation="MFHLKEQQTSIKQEIIAGLTTFFTMVYIVVVNPVILANAGVPFD QVFTATIIASIVGTLWMALAANYPIAIAPGMGLNAYLAFHVVSASDGGITYATAFSAV FTAGVLFIILSLTPLRKQLIEAIPNNLKYGITTGIGLFIAFIGLRQAGIVAADESNLV TLGNLHSPGVILTLVGLLISVVLMVLNVSGALFIGMAATALIAFFTGQLHFSKGFMSL PHLPEGLMISNPFTAFGDVIHHGLYAVVFSFLLVTIFDTTGTMIGVAEQAGLMKNNKL PNVRKALLADSTATTVGAVFGTSPTTAFIESSAGVAAGGRTGLTALTVAVMFAASMFF SPLVSALSGIAAITSPALIIVGSLMMGSVSNMNWKEMDEAFPAFLVILAMPLTSSIST GIALGFISYPIVKAARGKWREIHPLVIVFAILFFIQLFIL*" /label="pbuO CDS" gene 2504805..2506103 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /label="pbuO gene" promotor_-10 complement(2505126..2505145) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2505149) /Source="Nicolas_upshifts" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2505160..2505166) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2506090 /Source="Nicolas_upshifts" /id="D1546" /incds=0 /nref=43 /ntot=178 /MaxReadThrough="2.37859" /MaxDrop="5.35341" /score="16.9979166" /energy="-10.2" /TU="NA" /idTUdmin="U2329" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2506143..2507300) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390878.1" /db_xref="EnsemblGenomes-Gn:BSU30000" /db_xref="EnsemblGenomes-Tr:CAB14978" /db_xref="GOA:O35029" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG13861" /db_xref="UniProtKB/Swiss-Prot:O35029" /translation="MNGRTLFFRRLFDYYKYQFKVLHAVIDWTVALYIVLPAIAFVIY QYIDLMNGRGLLYEWSEVAEWRWLYAVCVLIMFTGSIRTFLMEADKVFLLQKKEIIYQ LKRYALLYSFLATLAKWLLLFFIVLPLISHSVLITFAESTALLCYLFGLHIFFLSLKQ DRIRKPRSISRWIGDTLVRAILFAGSAILIVFTERHLLALFGILFLFFSVIRSLKKTA SFTAFEAEVTEEKKSRLALAGLVMMMSQEAGMPKVKDRMRRKPLLYRNSKRIFKRRTI CTGYKELFFKVMLRNGEYARQMYMLLSAFTVLIFVSPIWLKVIALLVYTGVCRYILTL IFDKVMDAPFLIGTDKESDEYYRARKSCINILHYAFAACCFLAAAVSLLFT*" /label="ythQ CDS" gene complement(2506143..2507300) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /label="ythQ gene" downshifts complement(2506168) /Source="Nicolas_upshifts" /id="D1547" /incds=0 /nref=1 /ntot=153 /MaxReadThrough="3.07175" /MaxDrop="3.89104" /score="19.8243425" /energy="-11.2" /TU="NA" /idTUdmin="U2332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2506416..2506421 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2506436..2506454 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2506444 /Source="Nicolas_upshifts" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2507297..2508007) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_390879.1" /db_xref="EnsemblGenomes-Gn:BSU30010" /db_xref="EnsemblGenomes-Tr:CAB14979" /db_xref="GOA:O34977" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13860" /db_xref="UniProtKB/Swiss-Prot:O34977" /translation="MTNLLEASIEQAGYTSRKKVLTDVFLEVRKGELVGLIGANGAGK STAIKAILGLSEDFKGHIAWNDCSFAYIPEHPSFYEELTLWEHLDLISTLHGIEESEF AHRAQSLLQTFSLDHVKHELPVTFSKGMQQKLMLIQAFLSKPDMYVIDEPFIGLDPIS TKRFVDMLKAEKERGAGILMCTHVLDTAEKICDRFYMIEKGSLFLQGTLKDVQDKTGL EGQSLLDCFYKAVQGDRL*" /label="ythP CDS" gene complement(2507297..2508007) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /label="ythP gene" promotor_-10 complement(2508021..2508036) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2508038) /Source="Nicolas_upshifts" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2508048..2508057) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2508064..2508065 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2508077..2508182 /Source="Nicolas_S_feature" /locus_tag="new_3072180_3072285" /HighExp="S5, S4, S3, S8, S7, S6, G/S, Pyr, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1150" upshifts 2508077 /Source="Nicolas_upshifts" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2508085..2508095 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2508148..2508154 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2508169..2508188 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2508184..2508297 /Source="Nicolas_S_feature" /locus_tag="new_3072287_3072400" /HighExp="S4, S5, M0t90, S3, Etha, M9-stat, M40t90, LPhT, Heat, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1151" upshifts 2508184 /Source="Nicolas_upshifts" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2508298..2508519 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618461; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (DeoR family)" /protein_id="NP_390880.1" /db_xref="EnsemblGenomes-Gn:BSU30020" /db_xref="EnsemblGenomes-Tr:CAB14980" /db_xref="GOA:O32067" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13939" /db_xref="UniProtKB/Swiss-Prot:O32067" /translation="MKPSTNRMLTRIKSVYMFIQEKGLVTTQELVDEFGITPRTIQRD LNVLAYNDLVHSPSRGKWETTRKKVKITS*" /label="ytzE CDS" gene 2508298..2508519 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /label="ytzE gene" downshifts 2508502 /Source="Nicolas_upshifts" /id="D1548" /incds=0 /nref=166 /ntot=259 /MaxReadThrough="4.38243" /MaxDrop="4.90218" /score="20.9755494" /energy="-13.5" /TU="U2333,U2334" /idTUdmin="U2333" /TUdmin="-54" /isTUend="FALSE" /label="downshifts" downshifts 2508571 /Source="Nicolas_upshifts" /id="D1549" /incds=0 /nref=44 /ntot=172 /MaxReadThrough="-0.189589999999999" /MaxDrop="6.00369" /score="20.9755494" /energy="-13.5" /TU="NA" /idTUdmin="U2334" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2508640..2509359) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /EC_number="4.2.1.70" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11953756, 16511038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA pseudouridylate 516 synthase" /protein_id="NP_390882.2" /db_xref="EnsemblGenomes-Gn:BSU30035" /db_xref="EnsemblGenomes-Tr:CAB14982" /db_xref="GOA:O32068" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG13941" /db_xref="UniProtKB/Swiss-Prot:O32068" /translation="MRLDKLLANSGYGSRKEVKAVVKAGAVMIDGKPAKDVKEHVDPD TQEVTVYGEPVDYREFIYLMMNKPQGVLSATEDSRQQTVVDLLTPEEMRFEPFPAGRL DKDTEGFLLLTNDGQLAHRLLSPKKHVPKTYEVHLKSQISREDISDLETGVYIEGGYK TKPAKAEIKTNDSGNTVIYLTITEGKYHQVKQMAKAVGNEVVYLKRLSMGRVSLDPAL APGEYRELTEEELHLLNEPQA*" /label="rsuA CDS" gene complement(2508640..2509359) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /label="rsuA gene" downshifts complement(2508654) /Source="Nicolas_upshifts" /id="D1550" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="0.79865" /MaxDrop="2.6873" /score="21.6808891" /energy="-13.5" /TU="NA" /idTUdmin="U2335" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2509425) /Source="Nicolas_upshifts" /id="D1551" /incds=0 /nref=1 /ntot=76 /MaxReadThrough="4.50848" /MaxDrop="2.99899" /score="8.79816042" /energy="-9.5" /TU="U2335" /idTUdmin="U2335" /TUdmin="-617" /isTUend="FALSE" /label="downshifts" CDS complement(2509428..2511062) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_390883.1" /db_xref="EnsemblGenomes-Gn:BSU30050" /db_xref="EnsemblGenomes-Tr:CAB14983" /db_xref="GOA:O34674" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG13856" /db_xref="UniProtKB/Swiss-Prot:O34674" /translation="MSSKLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQY GYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVTGMIAFFIL YLSAPMFAEISLGGKDNNGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPT AVSQVVEQIVRIIFLLSATFLILKVFNGGLVIAVGYATFAALIGAFGGLVVLYIYWNK RKGSLLAMMPNTGPTANLSYKKMFFELFSYAAPYVFVGLAIPLYNYIDTNTFNKAMIE AGHQAISQDMLAILTLYVQKLVMIPVSLATAFGLTLIPTITESFTSGNYKLLNQQINQ TMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPELGANILLWYSPVAILFSLFTVN AAILQGINKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIM IKRHAGYSYKILVKRTVLMLVLSAIMGIAVKIVQWVLGFFISYQDGQMQAAIVVVIAA AVGGAVYLYCGYRLGFLQKILGRRLPGFFRKGRHAG*" /label="murJ CDS" gene complement(2509428..2511062) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /label="murJ gene" misc_feature complement(2511094..2511113) /Source="Nicolas_upshift_promotors" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2511110) /Source="Nicolas_upshifts" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2511180..2511184 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2511200..2511219 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2511218 /Source="Nicolas_upshifts" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2511264..2512526 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(FAD)-utilizing dehydrogenase" /protein_id="NP_390884.2" /db_xref="EnsemblGenomes-Gn:BSU30060" /db_xref="EnsemblGenomes-Tr:CAB14984" /db_xref="InterPro:IPR004792" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13850" /db_xref="UniProtKB/Swiss-Prot:Q795R8" /translation="MKQYDVIVIGGGPSGLMAAIAAGEQGAGVLLIDKGNKLGRKLAI SGGGRCNVTNRLPVEEIIKHIPGNGRFLYSAFSEFNNEDIIKFFENLGIQLKEEDHGR MFPVTDKAQSVVDALLNRLKQLRVTIRTNEKIKSVLYEDGQAAGIVTNNGEMIHSQAV IIAVGGKSVPHTGSTGDGYEWAEAAGHTITELFPTEVPVTSGEPFIKQKTLQGLSLRD VAVSVLNKKGKPIITHKMDMLFTHFGLSGPAILRCSQFVVKELKKQPQVPIRIDLYPD INEETLFQKMYKELKEAPKKTIKNVLKPWMQERYLLFLLEKNGISPNVSFSELPKDPF RQFVRDCKQFTVLANGTLSLDKAFVTGGGVSVKEIDPKKMASKKMEGLYFCGEILDIH GYTGGYNITSALVTGRLAGLNAGQYARS*" /label="ytfP CDS" gene 2511264..2512526 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /label="ytfP gene" S_feature 2512527..2512625 /Source="Nicolas_S_feature" /locus_tag="new_3076630_3076728" /HighExp="LBGstat, Lbstat, M0t90, T2.30H, T1.0H, T0.30H, BC, T2.0H, T1.30H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1152" promotor_-35 2512599..2512605 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2512621..2512639 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2512627..2512714 /Source="Nicolas_S_feature" /locus_tag="new_3076730_3076817" /HighExp="Etha, LBGstat, Salt, M9-stat, Lbstat, LBGtran, Sw, C30, Gly, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1153" upshifts 2512627 /Source="Nicolas_upshifts" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2512715..2514253 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14996799, 15849754, 16850406, 8752321, 9925583" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14996799, 15849754, 16850406, 8752321, 9925583; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine transporter" /protein_id="NP_390885.1" /db_xref="EnsemblGenomes-Gn:BSU30070" /db_xref="EnsemblGenomes-Tr:CAB14985" /db_xref="GOA:P54417" /db_xref="InterPro:IPR000060" /db_xref="InterPro:IPR018093" /db_xref="SubtiList:BG11958" /db_xref="UniProtKB/Swiss-Prot:P54417" /translation="MLKHISSVFWIVIAITAAAVLWGVISPDSLQNVSQSAQAFITDS FGWYYLLVVSLFVGFCLFLIFSPIGKIKLGKPDEKPEFGLLSWFAMLFSAGMGIGLVF YGAAEPISHYAISSPSGETETPQAFRDALRYTFFHWGLHAWAIYAIVALCIAYFQFRK GAPGLISSTLSPILGDKVNGPIGKAIDCIAVFATVVGVSTSLGLGATQINGGLNYLFG IPNAFIVQLVLIIIVTVLFLLSAWSGLGKGIKYLSNTNMVLAGLLMLFMLVVGPTVLI MNSFTDSIGQYIQNIVQMSFRLTPNDPEKREWINSWTIFYWAWWISWSPFVGIFIARV SRGRTIREFLIGVLVTPCILTFLWFSIFGVSAMDLQQKGAFNVAKLSTETMLFGTLDH YPLTMVTSILALILIAVFFITSADSATFVLGMQTSYGSLNPANSVKLSWGIIQSAMAA VLLYSGGLAALQNTAILAALPFSIVILLMIASLYQSLSKERREIKKAEKLDKPRSPRV KKAY*" /label="opuD CDS" gene 2512715..2514253 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /label="opuD gene" downshifts 2514233 /Source="Nicolas_upshifts" /id="D1552" /incds=0 /nref=231 /ntot=263 /MaxReadThrough="2.0688" /MaxDrop="6.06429" /score="27.1497809" /energy="-16.3" /TU="NA" /idTUdmin="U2336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2514290..2514472) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8990290" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390886.1" /db_xref="EnsemblGenomes-Gn:BSU30080" /db_xref="EnsemblGenomes-Tr:CAB14986" /db_xref="GOA:P94496" /db_xref="InterPro:IPR020296" /db_xref="SubtiList:BG12339" /db_xref="UniProtKB/Swiss-Prot:P94496" /translation="MLKVAVFDEEHEKDLQTEINSFLKGISEEQLIDIKYTVSAACDP DGEQLYCFSALILYRK*" /label="yteV CDS" gene complement(2514290..2514472) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /label="yteV gene" downshifts complement(2514309) /Source="Nicolas_upshifts" /id="D1553" /incds=0 /nref=10 /ntot=61 /MaxReadThrough="0.597819999999999" /MaxDrop="4.78152" /score="32.507978" /energy="-16.3" /TU="NA" /idTUdmin="U2338" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2514487..2514505) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2514507) /Source="Nicolas_upshifts" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2514521..2514526) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2514540..2515208) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme for rhamnogalaturonan degradation" /protein_id="NP_390887.1" /db_xref="EnsemblGenomes-Gn:BSU30090" /db_xref="EnsemblGenomes-Tr:CAB14987" /db_xref="GOA:O34378" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG13846" /db_xref="UniProtKB/Swiss-Prot:O34378" /translation="MEHDGSLGRMLRFCEWIMRFAYTNLLWLFFTLLGLGVFGIMPAT AALFAVMRKWIQGQDNVPVLKTFWQEYKGEFFRSNLLGAVLALIGVIIYIDLALIYPS HFLLHILRFAIMIFGFLFVSMLFYVFPLLVHFDWKKRLYVKFSLLLSVAYLQYTLTML ALTVALFFLLAYLPGIVPFFSVSLISYCHMRIVYAVLLKVEQHGGEPQRKSHIRKAFY PETR*" /label="rmgU CDS" gene complement(2514540..2515208) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /label="rmgU gene" CDS complement(2515230..2516516) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase of rhamnogalaturonan degradation" /protein_id="NP_390888.1" /db_xref="EnsemblGenomes-Gn:BSU30100" /db_xref="EnsemblGenomes-Tr:CAB14988" /db_xref="GOA:O34371" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13845" /db_xref="UniProtKB/Swiss-Prot:O34371" /translation="MKNIVFCGLSSRAFSMFIKPLMERFSTHYEITGLLDADPKRFAV CKKKFPELAHVPEFSEDAFDEMMRVSKPDIVIVAGRDDTHVAYIVKSLQWNTDVITEK PMVTTVQDANRVLEAEAKSEGKVTVAFNYRYSPFHRKIKEMILDGKIGRVTSVDLNWY IDTYHGASYFKRWNRSRQFSGGLSVHKSTHHFDLVNWWLGQNPEEVFAYGALNYYGPD SEWNPLPEEDGRFCGTCRVKEKCHYYSRWHPRSSKASIKDDHLEAGDQSSLYTAYRPD ACIFDEEIDIEDTYVAAVKYDGGALLSYSIIFSAPYEGYRLTINGTKGRIESNEFHEP SRIPFAFPEQTIEYYPLFESKQTIQVVKNEGGHGGGDPLLLEDLFLGKDPLRRYDILA GAEAGAYSIAVGEGMWRSVAEKKPIGMKELFQMQNV*" /label="rmgT CDS" gene complement(2515230..2516516) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /label="rmgT gene" CDS complement(2516528..2517031) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17449691, 23504016; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein required for rhamnogalaturonan transport and degradation" /protein_id="NP_390889.2" /db_xref="EnsemblGenomes-Gn:BSU30110" /db_xref="EnsemblGenomes-Tr:CAB14989" /db_xref="GOA:C0SP80" /db_xref="SubtiList:BG13844" /db_xref="UniProtKB/Swiss-Prot:C0SP80" /translation="MTKRIRTALCVIVSVLFLASCSSRPDGMHVILFSDMQAGVQEKI KKAAEQNAGKVDIFPAFQEKLLTEITAHEGDVFIVPEDMFQAYDDPENFQPLNGLPPE KTSPYTTVNKKTGEKTIYAVQIEKGKKQLNGYSFQLNRDMAAFIPVYAEKTEEALQLI SQLTEAR*" /label="rmgS CDS" gene complement(2516528..2517031) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /label="rmgS gene" CDS complement(2517028..2518149) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /EC_number="3.2.1.172" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15148314, 15906318, 16781735, 16870154, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15148314, 15906318, 16781735, 16870154, 17449691, 23504016; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="unsaturated rhamnogalacturonyl hydrolase" /protein_id="NP_390890.3" /db_xref="EnsemblGenomes-Gn:BSU30120" /db_xref="EnsemblGenomes-Tr:CAB14990" /db_xref="GOA:O34559" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="PDB:1NC5" /db_xref="PDB:2D8L" /db_xref="PDB:2GH4" /db_xref="SubtiList:BG13843" /db_xref="UniProtKB/Swiss-Prot:O34559" /translation="MGSMDQSIAVKSPLTYAEALANTIMNTYTVEELPPANRWHYHQG VFLCGVLRLWEATGEKRYFEYAKAYADLLIDDNGNLLFRRDELDAIQAGLILFPLYEQ TKDERYVKAAKRLRSLYGTLNRTSEGGFWHKDGYPYQMWLDGLYMGGPFALKYANLKQ ETELFDQVVLQESLMRKHTKDAKTGLFYHAWDEAKKMPWANEETGCSPEFWARSIGWY VMSLADMIEELPKKHPNRHVWKNTLQDMIKSICRYQDKETGLWYQIVDKGDRSDNWLE SSGSCLYMYAIAKGINKGYLDRAYETTLLKAYQGLIQHKTETSEDGAFLVKDICVGTS AGFYDYYVSRERSTNDLHGAGAFILAMTELEPLFRSAGK*" /label="rmgQ CDS" gene complement(2517028..2518149) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /label="rmgQ gene" CDS complement(2518157..2519122) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease for unsaturated rhamnogalacturonan" /protein_id="NP_390892.2" /db_xref="EnsemblGenomes-Gn:BSU30135" /db_xref="EnsemblGenomes-Tr:CAB14992" /db_xref="GOA:C0SPB3" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13841" /db_xref="UniProtKB/Swiss-Prot:C0SPB3" /translation="MKTAEAQAPAVDAVIFKKEKRKRLLIKLIQQKYLYLMILPGCIY FLLFKYVPMWGIVIAFQDYQPFLGILGSEWVGLKHFIRLFTEPTFFLLLKNTLVLFAL NLAIFFPVPILLALLLNEVRIALFKKFVQTLIYIPHFMSWVIVVSLSFVLLTVDGGLI NELIVFFGGEKINFLLNEEWFRPLYILQVIWREAGWSTIIYLAAITAVDPQLYEAAKM DGAGRLRQMWHITLPAIKSVIVVLLILKIGDTLELGFEHVYLLLNATNREVAEIFDTY VYTAGLKQGQFSYSTAVGVFKAAVGLILVMLANRLAKKFGEEGIY*" /label="rmgP CDS" gene complement(2518157..2519122) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /label="rmgP gene" upshifts complement(2519148) /Source="Nicolas_upshifts" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2519149..2519168) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2519183..2519190) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2519278..2519285 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2519298 /Source="Nicolas_upshifts" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2519301..2519320 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2519338..2521656 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="membrane bound transcriptional regulator (controlling rhamnogalacturonan degradation)" /protein_id="NP_390893.1" /db_xref="EnsemblGenomes-Gn:BSU30150" /db_xref="EnsemblGenomes-Tr:CAB14993" /db_xref="GOA:O32071" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG13838" /db_xref="UniProtKB/Swiss-Prot:O32071" /translation="MGGFMKRSQYKFYYKLITFFCLLSTIPVILVGLFSYEHSQKTAI SNVSEEKFDTLQQTQQSIEHILKTVDHSLTHYVSSPPLLRTLSEPLHSDQFQIYNQVN QELNYLQSFDTDLSNMTLVSYTKKWYMNNSGLYRLNTDTLHEAASAYTKQKASRSYWT LEENNHLISTKEGTAENCRYNINLIKQLPLNSTNTKGLAAASIPSCSLVKNMPGYSNA NNLFIIDEKGLIILHNNMSDVGESLHNDGFVQKVLAQTANSGQFETVIDRIHYKVTYQ KSDYNAWTYFSLVSLPELKKEAKSIGWITFAVCLILLTLSLLFSWLGSRHFYKPIRVL YESFARHGAIQEKQQPPQNEFELIEQSFKQLKDRNDDLEETMKQQATHLQQYFMVRLM LGKLTDEEVDNRFESLGLKQNWRHLALLVLQIDTLNHTPYEKKDMDLLLFAVNSLIER NIPTDKHLAPAVVDKQQATILINQSGTKEEFMAELNETARMIQEKAEAELQLSVSIGI SQPFDVLTKAKTAYAEGSEALKYRLKAENKSIIFYEDLDQKKTFKTHFPKQLQHELFD AVKAGDKEKADKCLHAILQAIFTQNTNPYQFQIAIARFLNHVIELMHVLGIELFELEE NKMLYDQIFELKTFEDTENWLKNEFIDPMTDKVNARADAQYKNISDNIIHIIHHEFES ELTLDEIARRLHYNPNYLSSIFKKEMGISFSEYVSSYRHHMAKSWLAETDMAVKDIAE KLKYKNSQNFIRSFKKLEGITPGNYRQQKRSM*" /label="rmgR CDS" gene 2519338..2521656 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /label="rmgR gene" downshifts 2521646 /Source="Nicolas_upshifts" /id="D1554" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="1.43431" /MaxDrop="3.6268" /score="-7.37324741" /energy="-10.2" /TU="NA" /idTUdmin="U2340" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" CDS complement(2521697..2523193) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_390894.3" /db_xref="EnsemblGenomes-Gn:BSU30160" /db_xref="EnsemblGenomes-Tr:CAB14994" /db_xref="GOA:Q795R2" /db_xref="SubtiList:BG13836" /db_xref="UniProtKB/Swiss-Prot:Q795R2" /translation="MGNKWRVLLIVLVLALGGVLAGCKGTDQSSAEGKAGPDSKVKLS WMAILYHQQPPKDRAIKEIEKLTNTELDITWVPDAVKEDRLNAALAAGNLPQIVTIQD IKNSSVMNAFRSGMFWEIGDYIKDYPNLNKMNKLINKNVTIDGKLYGIYRERPLSRQG IVIRKDWLDNLNLKTPKTLDELYEVAKAFTEDDPDKDGKDDTFGLADRNDLIYGAFKT IGSYEGMPTDWKESGGKFTPDFMTQEYKDTMNYMKKLRDNGYMNKDFPVTSKTQQQEL FSQGKAGIYIGNMVDAVNLRDHASDKSMKLEIINRIKGPDGKERVWASGGHNGVFAFP KTSVKTEAELKRILAFFDRIAEEDVYSLMTYGIDGVHYNKGEDKTFTRKESQVKDWQT DIQPLSALIAIDKAYLKNTGDPLRTAYEELTEDNEKIIVSNPAESLYSASESERGDEL KKIIDDATYKYMIGDITESQFDKEVEKWESSGGKQIIQEYEEAFKQAK*" /label="ytcQ CDS" gene complement(2521697..2523193) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /label="ytcQ gene" downshifts complement(2521699) /Source="Nicolas_upshifts" /id="D1555" /incds=0 /nref=26 /ntot=160 /MaxReadThrough="-0.0485899999999999" /MaxDrop="5.21039" /score="6.31011081" /energy="-11.2" /TU="NA" /idTUdmin="U2341" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2523218..2524078) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390895.1" /db_xref="EnsemblGenomes-Gn:BSU30170" /db_xref="EnsemblGenomes-Tr:CAB14995" /db_xref="GOA:P53561" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11788" /db_xref="UniProtKB/Swiss-Prot:P53561" /translation="MKNRLFDMLIYGFLLMFALICVLPFIHVIAASFATVEEVVSKKF ILIPTTFSLDAYRYIFSTDIIYKSLLVSVFVTVIGTAVSMFLSSLMAYGLSRRDLIGR QPLMFLVVFTMLFSGGMIPTFLVVKSLGLLDSYWALILPTAINAFNLIILKNFFQNIP SSLEESAKIDGCNDLGIFFKIVLPLSLPAIATISLFYAVTYWNTYMTAILYLNDSAKW PIQVLLRQIVIVSSGMQGDMSEMGSGSPPPEQTIKMAVIVVATIPVLLVYPFIQKHFA KGALLGSVKG*" /label="ytcP CDS" gene complement(2523218..2524078) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /label="ytcP gene" promotor_-10 complement(2524154..2524173) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2524163) /Source="Nicolas_upshifts" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2524189..2524196) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2524285..2525046) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-dependent nucleoside-diphosphate-sugar epimerase" /protein_id="NP_390896.2" /db_xref="EnsemblGenomes-Gn:BSU30180" /db_xref="EnsemblGenomes-Tr:CAB14996" /db_xref="GOA:P53560" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11787" /db_xref="UniProtKB/Swiss-Prot:P53560" /translation="MKKVLIAGGNGVIGRLLAEGLISDYEVTVLDKDHFDGKASSIQA DAANYEELLKKIPKDTDAILNLLAVKIKYDIMDIAEFEKMTDVFYRASYYLCRAAAEL GIQKLVFASSNHVTDVYEKDGRSLLGREITTSDYPLSKNLYGVLKLTSEQIGHLFYLE NKLSVINLRIGTVVTDEMDTLHEKERTKKTLLSHPDLLSIFKAAIETNIRYGTYYAVS DNPGRPWSIESAVNELGFSPQINTAELLNEEENGA*" /label="ytbQ CDS" gene complement(2524285..2525046) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /label="ytbQ gene" downshifts complement(2524314) /Source="Nicolas_upshifts" /id="D1556" /incds=0 /nref=153 /ntot=196 /MaxReadThrough="1.18543" /MaxDrop="5.85654" /score="12.3836957" /energy="-11.1" /TU="NA" /idTUdmin="U2344" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2525047..2525122) /Source="Nicolas_S_feature" /locus_tag="new_3089150_3089225_c" /HighExp="LPh, HPh, aero, Gly, HiOs, BMM, GM-0.1, GM 10, GM 15, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1154" CDS complement(2525123..2526310) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /EC_number="1.14.14.46" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 for pimelic acid formation for biotin biosynthesis" /protein_id="NP_390897.1" /db_xref="EnsemblGenomes-Gn:BSU30190" /db_xref="EnsemblGenomes-Tr:CAB14997" /db_xref="GOA:P53554" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:3EJB" /db_xref="PDB:3EJD" /db_xref="PDB:3EJE" /db_xref="SubtiList:BG11528" /db_xref="UniProtKB/Swiss-Prot:P53554" /translation="MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV TFE*" /label="bioI CDS" gene complement(2525123..2526310) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /label="bioI gene" CDS complement(2526379..2527386) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /EC_number="2.8.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin synthase" /protein_id="NP_390898.1" /db_xref="EnsemblGenomes-Gn:BSU30200" /db_xref="EnsemblGenomes-Tr:CAB14998" /db_xref="GOA:P53557" /db_xref="InterPro:IPR002684" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010722" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024177" /db_xref="SubtiList:BG11525" /db_xref="UniProtKB/Swiss-Prot:P53557" /translation="MNQWMELADRVLAGAEVTDEEALSILHCPDEDILLLMHGAFHIR KHFYGKKVKLNMIMNAKSGLCPENCGYCSQSAISKAPIESYRMVNKETLLEGAKRAHD LNIGTYCIVASGRGPSNREVDQVVDAVQEIKETYGLKICACLGLLKPEQAKRLKDAGV DRYNHNLNTSQRNHSNITTSHTYDDRVNTVEIAKESGLSPCSGAIIGMKETKQDVIDI AKSLKALDADSIPVNFLHAIDGTPLEGVNELNPLYCLKVLALFRFINPSKEIRISGGR EVNLRTLQPLGLYAANSIFVGDYLTTAGQEETEDHKMLSDLGFEVESVEEMKASLSAK S*" /label="bioB CDS" gene complement(2526379..2527386) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /label="bioB gene" CDS complement(2527389..2528084) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /EC_number="6.3.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242, 20565114" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242, 20565114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dethiobiotin synthetase" /protein_id="NP_390899.1" /db_xref="EnsemblGenomes-Gn:BSU30210" /db_xref="EnsemblGenomes-Tr:CAB14999" /db_xref="GOA:P53558" /db_xref="InterPro:IPR004472" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11526" /db_xref="UniProtKB/Swiss-Prot:P53558" /translation="MRGFFVTGTDTEVGKTVISSGLAALLKDNNRHVGVYKPFLSGIS RHHPDSDTSLLKDMSQTSLSHEDITPFAFKAPLAPYVAGKLEGKTVTMEEVLSHWGRI REKHECFIVEGAGGISVPLGEDYLVSHVIKALQLPMIIVARPRLGTINHTFLTVKYAE SMGLPIAGIIINGISDSPDEDEKTNPEMIERLCGVPILGVTPKLANVTKETVLHMVKD HINLSLLMNQVGV*" /label="bioD CDS" gene complement(2527389..2528084) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /label="bioD gene" CDS complement(2528081..2529250) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11322938, 11717296, 12368242, 15056910, 16557306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11322938, 11717296, 12368242, 15056910, 16557306; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="8-amino-7-oxononanoate synthase (pimeloyl-CoA-dependent)" /protein_id="NP_390900.1" /db_xref="EnsemblGenomes-Gn:BSU30220" /db_xref="EnsemblGenomes-Tr:CAB15000" /db_xref="GOA:P53556" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11527" /db_xref="UniProtKB/Swiss-Prot:P53556" /translation="MKIDSWLNERLDRMKEAGVHRNLRSMDGAPVPERNIDGENQTVW SSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKLTEAA LLFSSGYLANVGVLSSLPEKEDVILSDQLNHASMIDGCRLSKADTVVYRHIDMNDLEN KLNETQRYQRRFIVTDGVFSMDGTIAPLDQIISLAKRYHAFVVVDDAHATGVLGDSGQ GTSEYFGVCPDIVIGTLSKAVGAEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAA AHEAFNIIEASREKRQLLFSYISMIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVLFA EKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDHLLQTFHSIGKELHII*" /label="bioFC CDS" gene complement(2528081..2529250) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /label="bioFC gene" promotor_-35 2528117..2528124 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2528139..2528158 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2528157 /Source="Nicolas_upshifts" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2529240..2530586) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /EC_number="2.6.1.105" /function="4.1: Biotin" /experiment="publication(s) with functional evidences, PMID:15880481, 20565114, 21437340" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15880481, 20565114, 21437340; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lysine-8-amino-7-oxononanoate aminotransferase" /protein_id="NP_390901.1" /db_xref="EnsemblGenomes-Gn:BSU30230" /db_xref="EnsemblGenomes-Tr:CAB15001" /db_xref="GOA:P53555" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR005815" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3DOD" /db_xref="PDB:3DRD" /db_xref="PDB:3DU4" /db_xref="SubtiList:BG11524" /db_xref="UniProtKB/Swiss-Prot:P53555" /translation="MTHDLIEKSKKHLWLPFTQMKDYDENPLIIESGTGIKVKDINGK EYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTLLGMTNVPATQLAETLIDISPK KLTRVFYSDSGAEAMEIALKMAFQYWKNIGKPEKQKFIAMKNGYHGDTIGAVSVGSIE LFHHVYGPLMFESYKAPIPYVYRSESGDPDECRDQCLRELAQLLEEHHEEIAALSIES MVQGASGMIVMPEGYLAGVRELCTTYDVLMIVDEVATGFGRTGKMFACEHENVQPDLM AAGKGITGGYLPIAVTFATEDIYKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLAL FESENIVEQVAEKSKKLHFLLQDLHALPHVGDIRQLGFMCGAELVRSKETKEPYPADR RIGYKVSLKMRELGMLTRPLGDVIAFLPPLASTAEELSEMVAIMKQAIHEVTSLED*" /label="bioK CDS" gene complement(2529240..2530586) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /label="bioK gene" promotor_-35 2529656..2529660 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2529675 /Source="Nicolas_upshifts" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2529676..2529694 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2530576..2531352) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /EC_number="6.2.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11368323, 11717296, 21437340, 28196402, 29054876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11368323, 11717296, 21437340, 28196402, 29054876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-carboxyhexanoate-CoA ligase (pimeloyl-CoA synthase)" /protein_id="NP_390902.3" /db_xref="EnsemblGenomes-Gn:BSU30240" /db_xref="EnsemblGenomes-Tr:CAB15002" /db_xref="GOA:P53559" /db_xref="InterPro:IPR005499" /db_xref="PDB:5FLG" /db_xref="PDB:5FLL" /db_xref="PDB:5FM0" /db_xref="PDB:5G1F" /db_xref="SubtiList:BG11529" /db_xref="UniProtKB/Swiss-Prot:P53559" /translation="MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNA LLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEG VSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWAL HSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKE YGTEEGCRVFFIDGSNDVNTYIHDLEKQPILIEWEEDHDS*" /label="bioW CDS" gene complement(2530576..2531352) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /label="bioW gene" S_feature complement(2531353..2531445) /Source="Nicolas_S_feature" /locus_tag="new_3095456_3095548_c" /HighExp="T-5.40H, GM 60, LPh, GM 25, HPh, MG 120, M9-exp, BMM, GM 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1155" promotor_-10 complement(2531431..2531450) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2531445) /Source="Nicolas_upshifts" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2531465..2531472) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2531562..2532461) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390903.1" /db_xref="EnsemblGenomes-Gn:BSU30250" /db_xref="EnsemblGenomes-Tr:CAB15003" /db_xref="GOA:O34973" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11786" /db_xref="UniProtKB/Swiss-Prot:O34973" /translation="MRAERRKQLFRLLGDLPDRRPISVETLRIEEREENIVETLLLDL NGHEKAPAYFVKPKKTEGPCPAVLFQHSHGGQYDRGKSELIEGADYLKTPSFSDELTS LGYGVLAIDHWGFGDRRGKAESEIFKEMLLTGKVMWGMMIYDSLSALDYMQSRSDVQP DRIGTIGMSMGGLMAWWTAALDDRIKVCVDLCSQVDHHVLIKTQNLDRHGFYYYVPSL AKHFSASEIQSLIAPRPHLSLVGVHDRLTPAEGVDKIEKELTAVYAGQGAADCYRVVR SASGHFETAVIRHEAVRFLQKWL*" /label="ytaP CDS" gene complement(2531562..2532461) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /label="ytaP gene" promotor_-10 complement(2532484..2532502) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2532501) /Source="Nicolas_upshifts" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2532513..2532521) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2532591..2532598 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2532614..2532633 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2532620 /Source="Nicolas_upshifts" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2532679..2533713 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12847288; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_390904.1" /db_xref="EnsemblGenomes-Gn:BSU30260" /db_xref="EnsemblGenomes-Tr:CAB15004" /db_xref="GOA:O34829" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12626" /db_xref="UniProtKB/Swiss-Prot:O34829" /translation="MVRIKDIALKAKVSSATVSRILNEDESLSVAGETRQRVINIAEE LGYQTVAKRRKSRGQKQRAQPLIGVLSCLSPDQERQDPYFSSIRKGIEKECFEQEIFI TNSIHLGSFQEHIFRELDGVIVIGRVHDEAVKHISGRLEHAVFINHSPDPQAYDSIGI DFESASRQAIDHLFDLGYKRLGYIGGQEKEHTLKDGQSIRRTIEDKRLTAFLESAAPQ PEHVLIGEYSMREGYRLMKKAIDQGHLPEAFFIASDSMAIGALKALQEAGLQVPRDTA IVSFNGIEEAEFASTPLTTVKVYTEEMGRTGVKLLLDRLNGRTLPQHVTLPTTLIVRQ SCGCTAKEVT*" /label="msmR CDS" gene 2532679..2533713 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /label="msmR gene" promotor_-35 2533662..2533669 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2533684..2533692 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2533701 /Source="Nicolas_upshifts" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2533747..2535027 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8449892, 12847288, 16707683, 18954360, 28036052; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="multiple sugar-binding lipoprotein" /protein_id="NP_390905.1" /db_xref="EnsemblGenomes-Gn:BSU30270" /db_xref="EnsemblGenomes-Tr:CAB15005" /db_xref="GOA:O34335" /db_xref="InterPro:IPR006059" /db_xref="PDB:4R6H" /db_xref="SubtiList:BG12625" /db_xref="UniProtKB/Swiss-Prot:O34335" /translation="MKHTFVLFLSLILLVLPGCSAEKSSADTAKKTLTIYSTMSTDSE RDTFRKLAAAFEKEHSDIHVSLHFPGNDYENMMRVRMAANDLPDLFDTHGWGKIRYGE YTADLRDMKWTQDLDPNLNSILKNKSGKVYAYPINQAKDGLAYNRNILDRYGIAPPET MDDFIKALRTIKEKSKGSIVPFWFAGYDKSSFAQYYDQFATPLLITDPAHNEKKQLIN GTFQWSKFTYLSEILKQMQKEKLINIDAVTAKKSQLIELMAQNKIAFTMQGGTLGQDV AQINPNVKVGIIPTPAIHPGDDPIWIGGERYTLAAWKDSPQLKEAKDFIAFMARPANA KQMAEATSLPSGLTNVKADIFYANDYEYYQDVKVEPYFDRLYLPNGMWDVLGTVGQEL AADILAPQDISQKLGREYKRLREQSETQGAENNE*" /label="msmE CDS" gene 2533747..2535027 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /label="msmE gene" CDS 2535020..2535931 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 12847288, 15849754, 16707683, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="carbohydrate ABC transporter (permease)" /protein_id="NP_390906.1" /db_xref="EnsemblGenomes-Gn:BSU30280" /db_xref="EnsemblGenomes-Tr:CAB15006" /db_xref="GOA:O34706" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12565" /db_xref="UniProtKB/Swiss-Prot:O34706" /translation="MSEIARDVHVKQVKPKKQSSLWWMYIPALLSVLVFMIYPFVKGT LITFTNWNGFSQVYQWVGFAQYERLFSDPDTWHILKNTLHYGLGSTFFQNVVGLLYAL LLNQSIKTKAVTRTIVYLPVMISPLIMGYIWYFFFSYDGGALNDLLGVFGISPINALA SPSLNPWIIVMINTYQYVGIAMVVYLAGLQSIPKDYYEAAQMDGAKQGQQFFTITLPL LMPSITINIVINIIGGLKLFDVIIALTAGGPGNASQSMSTFMYDLYFKRQDAGYAATQ GIFMAFVILIISFCALAYFKRKETEMS*" /label="msmF CDS" gene 2535020..2535931 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /label="msmF gene" CDS 2535928..2536758 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 15849754, 16707683, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="maltose and multiple sugars ABC transporter (permease)" /protein_id="NP_390907.1" /db_xref="EnsemblGenomes-Gn:BSU30290" /db_xref="EnsemblGenomes-Tr:CAB15007" /db_xref="GOA:O34518" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12564" /db_xref="UniProtKB/Swiss-Prot:O34518" /translation="MRAARTKSMRIITLLAAIVACAHFIPFYILLTTSLKAKGDYSSK WIFPADISFHNFSEAWERASLGNSFINTMIITGFSALLLIIFGSLAAYPLARRETKLN KAVFALLISIMIIPPLTSMVPLYRMVVDAGMVNTHAIAIFINTAAYMPLTVFLYSGFI RSTIPKELVEAARIDGAGMLKIFFTIVFPLLKPITATICIISCVFIWNDYQFAIFFLQ DQKVQTLTVAMAGFFGENANNLHLVAAAALMAMLPMVVLFLALQKYFIAGLSSGAVKG *" /label="msmG CDS" gene 2535928..2536758 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /label="msmG gene" promotor_-35 2536731..2536735 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2536751..2536770 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2536759 /Source="Nicolas_upshifts" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2536778..2538076 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /EC_number="3.2.1.22" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12847288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-D-galactoside galactohydrolase" /protein_id="NP_390908.1" /db_xref="EnsemblGenomes-Gn:BSU30300" /db_xref="EnsemblGenomes-Tr:CAB15008" /db_xref="GOA:O34645" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12615" /db_xref="UniProtKB/Swiss-Prot:O34645" /translation="MKKITFIGAGSTIFAKNVLGDCLLTEALNGFEFALYDIDPKRLQ ESQLMLENLRDRYNPSVAINSYDDRKLALQNAGYVINAIQVGGYKPSTVIDFEIPKRY GLRQTIADTVGIGGIFRSLRTIPVLFDIAKDMEEMCPDAWFLNYTNPMATLTGAMLRY TNIKTIGLCHSVQVCTKDLFKALGMEHDGIEERIAGINHMAWLLEVKKDGTDLYPEIK RRAKEKQKTKHHDMVRFELMDKFGYYVTESSEHNAEYHPYFIKRNYPELISELQIPLD EYPRRCVKQIENWEKMRDDIVNNKNLTHERSKEYGSRIIEAMETNEPFTFGGNVLNTG LITNLPSKAVVEVTCVADRKKITPCFAGELPEQLAALNRTNINTQLMTIEAAVTRKKE AVYQAAMLDPHTSAELSMKDIISMCDDLFAAHGDWLPEYK*" /label="melA CDS" gene 2536778..2538076 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /label="melA gene" downshifts 2538057 /Source="Nicolas_upshifts" /id="D1557" /incds=0 /nref=12 /ntot=55 /MaxReadThrough="3.99614" /MaxDrop="3.96455" /score="26.0469828" /energy="-11.9" /TU="NA" /idTUdmin="U2346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2538098..2538409) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /EC_number="2.8.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390909.2" /db_xref="EnsemblGenomes-Gn:BSU30310" /db_xref="EnsemblGenomes-Tr:CAB15009" /db_xref="GOA:O32072" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG13932" /db_xref="UniProtKB/Swiss-Prot:O32072" /translation="MEIKEISTAALKEKIEADEELYLIDVREDEEVAEGMIPQAVHIR MGDIPEKMETLDKDKEYVFICRSGMRSMNVCKYLDEQGFKTVNVEGGMMAWEGETKPK N*" /label="ytwF CDS" gene complement(2538098..2538409) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /label="ytwF gene" downshifts complement(2538109) /Source="Nicolas_upshifts" /id="D1558" /incds=0 /nref=84 /ntot=254 /MaxReadThrough="2.71726" /MaxDrop="5.77228" /score="23.1306393" /energy="-11.9" /TU="NA" /idTUdmin="U2349" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2538433..2538452) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2538441) /Source="Nicolas_upshifts" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2538467..2538474) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2538475 /Source="Nicolas_upshifts" /id="D1559" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="0.749090000000001" /MaxDrop="4.59307" /score="20.1681452" /energy="-11.2" /TU="NA" /idTUdmin="U2346" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS complement(2538526..2540940) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /EC_number="6.1.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1317842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="leucyl-tRNA synthetase" /protein_id="NP_390910.1" /db_xref="EnsemblGenomes-Gn:BSU30320" /db_xref="EnsemblGenomes-Tr:CAB15010" /db_xref="GOA:P36430" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002302" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR025709" /db_xref="SubtiList:BG10676" /db_xref="UniProtKB/Swiss-Prot:P36430" /translation="MSFQHKEIEKKWQTYWLENKTFATLDNNEKQKFYALDMFPYPSG AGLHVGHPEGYTATDILSRMKRMQGYDVLHPMGWDAFGLPAEQYALDTGNDPAVFTKQ NIDNFRRQIQALGFSYDWDREINTTDPEYYKWTQWIFLKLYEKGLAYVDEVPVNWCPA LGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELDWPESIKDMQ RNWIGRSEGAHVHFAIDGHDDSFTVFTTRPDTLFGATYTVLAPEHALVENITTAEQKE AVEAYIKEIQSKSDLERTDLAKTKTGVFTGAYAINPVNGEKLPIWIADYVLASYGTGA VMAVPGHDERDFEFAKTFGLPVKEVVKGGNVEEAAYTGDGEHVNSDFLNGLHKQEAIE KVIAWLEETKNGEKKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTSTAVPEEELPLILP KTDEIKPSGTGESPLANIKEWVEVTDPETGKKGRRETNTMPQWAGSCWYFLRYIDPHN PDQLASPEKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVVPTKEPFQKLYNQ GMILGENNEKMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASIAWSESGLDGAR RFLDRVWRLFIEDSGELNGKIVEGAGETLERVYHETVMKVTDHYEGLRFNTGISQLMV FINEAYKATELPKEYMEGFVKLLSPVAPHLAEELWEKLGHSGTIAYEAWPVYDETKLV DDEVEIVVQLNGKVKAKLQVPADATKEQLEQLAQADEKVKEQLEGKTIRKIIAVPGKL VNIVAN*" /label="leuS CDS" gene complement(2538526..2540940) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /label="leuS gene" downshifts complement(2538530) /Source="Nicolas_upshifts" /id="D1560" /incds=0 /nref=115 /ntot=224 /MaxReadThrough="3.2803" /MaxDrop="4.46738" /score="33.3300042" /energy="-11.2" /TU="U2350" /idTUdmin="U2350" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" S_feature complement(2540941..2541036) /Source="Nicolas_S_feature" /locus_tag="new_3105044_3105139_c" /HighExp="G150, G180, G135, LBGexp, HPh, LBGtran, Paraq, Lbexp, H2O2, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.989" /label="S1156" misc_RNA complement(2541050..2541264) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /product="T-box riboswitch specific of leucine tRNA ligase" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201, 27169680; Product type n: RNA" /function="16.3: Control" /label="tboL RNA" gene complement(2541050..2541264) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /label="tboL gene" downshifts complement(2541081) /Source="Nicolas_upshifts" /id="D1561" /incds=0 /nref=8 /ntot=38 /MaxReadThrough="6.86098" /MaxDrop="4.90189" /score="40.6873438" /energy="-16.7" /TU="U2350" /idTUdmin="U2352" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2541276..2541295) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2541297) /Source="Nicolas_upshifts" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2541301..2541306 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2541310..2541315) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2541322..2541340 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2541335..2541775 /Source="Nicolas_S_feature" /locus_tag="new_3105438_3105878" /HighExp="S4, S5, S3, S8, S7, S6, T5.0H, LoTm, C30, M9-stat" /AntisenseName="ytvB" /AntisenseCor="0.57398798861917499" /AntisenseRegPval="-24.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1157" upshifts 2541335 /Source="Nicolas_upshifts" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2541367..2541702) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16923906; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein" /protein_id="NP_390911.3" /db_xref="EnsemblGenomes-Gn:BSU30330" /db_xref="EnsemblGenomes-Tr:CAB15011" /db_xref="GOA:O34881" /db_xref="InterPro:IPR025353" /db_xref="SubtiList:BG13929" /db_xref="UniProtKB/Swiss-Prot:O34881" /translation="MKMLHQVLIACVIGGIMGILGHVKKRGRLEKPRMTKRFIYLGFL EDWFIGMTASILLVLSADPDSGIQLVILSIISGYGGEAVLRSFDFVRELNSGGEPAES KRQTKTPPE*" /label="ytvB CDS" gene complement(2541367..2541702) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /label="ytvB gene" S_feature complement(2541697..2541961) /Source="Nicolas_S_feature" /locus_tag="new_3105800_3106064_c" /HighExp="S6, S8, S7, Etha, S5, M9-stat, B60, BT, B36, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1158" promotor_-10 complement(2541946..2541965) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-10" upshifts complement(2541961) /Source="Nicolas_upshifts" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="upshifts" promotor_-35 complement(2541980..2541987) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-35" promotor_-35 2542000..2542007 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2542021..2542040 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2542037 /Source="Nicolas_upshifts" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2542039..2542106 /Source="Nicolas_S_feature" /locus_tag="new_3106142_3106209" /HighExp="M40t90, Etha, dia5, HiOs, dia15, H2O2, BC, Diami, M0t90, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1159" CDS 2542107..2542892 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="blue light GTP-binding receptor" /protein_id="NP_390912.1" /db_xref="EnsemblGenomes-Gn:BSU30340" /db_xref="EnsemblGenomes-Tr:CAB15012" /db_xref="GOA:O34627" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036513" /db_xref="PDB:1IUM" /db_xref="PDB:2MWG" /db_xref="PDB:2PR5" /db_xref="PDB:2PR6" /db_xref="PDB:4GCZ" /db_xref="SubtiList:BG13928" /db_xref="UniProtKB/Swiss-Prot:O34627" /translation="MASFQSFGIPGQLEVIKKALDHVRVGVVITDPALEDNPIVYVNQ GFVQMTGYETEEILGKNCRFLQGKHTDPAEVDNIRTALQNKEPVTVQIQNYKKDGTMF WNELNIDPMEIEDKTYFVGIQNDITKQKEYEKLLEDSLTEITALSTPIVPIRNGISAL PLVGNLTEERFNSIVCTLTNILSTSKDDYLIIDLSGLAQVNEQTADQIFKLSHLLKLT GTELIITGIKPELAMKMNKLDANFSSLKTYSNVKDAVKVLPIM*" /label="blrA CDS" gene 2542107..2542892 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /label="blrA gene" S_feature 2542893..2542949 /Source="Nicolas_S_feature" /locus_tag="new_3106996_3107052" /HighExp="Sw, M40t90, BC, Etha, dia5, dia15, H2O2, Mt0, M0t90, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1160" CDS complement(2543129..2544322) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390913.1" /db_xref="EnsemblGenomes-Gn:BSU30350" /db_xref="EnsemblGenomes-Tr:CAB15013" /db_xref="GOA:O34546" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13925" /db_xref="UniProtKB/Swiss-Prot:O34546" /translation="MPRALKILVIGMFINVTGASFLWPLNTIYIHNHLGKSLTVAGLV LMLNSGASVAGNLCGGFLFDKIGGFKSIMLGIAITLASLMGLVFFHDWPAYIVLLTIV GFGSGVVFPASYAMAGSVWPEGGRKAFNAIYVAQNAGVAVGSALGGVVASFSFSYVFL ANAVLYLIFFFIVYFGFRNIQTGDASQTSVLDYDAVNSKAKFAALIILSGGYVLGWLA YSQWSTTIASYTQSIGISLSLYSVLWTVNGILIVLGQPLVSFVVKKWAESLKAQMVIG FIIFIVSFSMLLTAKQFPMFLAAMVILTIGEMLVWPAVPTIANQLAPKGKEGFYQGFV NSAATGGRMIGPLFGGVLVDHYGIRALVLSLLVLLLISIATTLLYDKRIKSAKETNKQ ASISS*" /label="yttB CDS" gene complement(2543129..2544322) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /label="yttB gene" downshifts complement(2543149) /Source="Nicolas_upshifts" /id="D1562" /incds=0 /nref=5 /ntot=47 /MaxReadThrough="2.03991" /MaxDrop="3.41948" /score="-7.70376219" /energy="-9.4" /TU="NA" /idTUdmin="U2354" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2544323..2544421) /Source="Nicolas_S_feature" /locus_tag="new_3108426_3108524_c" /HighExp="dia15, LBGstat, H2O2, G180, LPhT, Paraq, Oxctl, G150, G135, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1161" promotor_-10 complement(2544402..2544421) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2544421) /Source="Nicolas_upshifts" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2544435..2544442) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2544459..2544462 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2544477..2544496 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2544481 /Source="Nicolas_upshifts" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="upshifts" CDS 2544511..2545257 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390914.2" /db_xref="EnsemblGenomes-Gn:BSU30360" /db_xref="EnsemblGenomes-Tr:CAB15014" /db_xref="GOA:Q795Q5" /db_xref="InterPro:IPR006876" /db_xref="InterPro:IPR035451" /db_xref="SubtiList:BG13924" /db_xref="UniProtKB/Swiss-Prot:Q795Q5" /translation="MEMVLAFLGFLACLIALGYGLYHLVRYVLKKEKRFSKRLFWPLF IGGLVLLFTGAALAEPDTAAANAEKKYSALNAEYKNLTKEHEELEKEYKSVSSEAKKL KDNKEDQDKLEKLKNENSDLKKTQKSLKAEIKELQENQKQLKEDAKTAKAENETLRQD KTKLENQLKETESQTASSHEDTGSSSNNTSKSDETKTADKAEGCNIKGSRNGIYHTPG STYYDRTTDPAEMFCSVEEAEAAGYRAPKR*" /label="yttA CDS" gene 2544511..2545257 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /label="yttA gene" downshifts 2545152 /Source="Nicolas_upshifts" /id="D1563" /incds=1 /nref=2 /ntot=94 /MaxReadThrough="4.11368" /MaxDrop="3.01036" /score="23.2955589" /energy="-11.6" /TU="U2355" /idTUdmin="U2355" /TUdmin="-99" /isTUend="FALSE" /label="downshifts" downshifts 2545251 /Source="Nicolas_upshifts" /id="D1564" /incds=0 /nref=31 /ntot=169 /MaxReadThrough="1.73994" /MaxDrop="4.19129" /score="23.2955589" /energy="-11.6" /TU="NA" /idTUdmin="U2355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2545294..2547234) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612242, 15849754, 16850406, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 15849754, 16850406, 17905982, 25118291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease)" /protein_id="NP_390915.1" /db_xref="EnsemblGenomes-Gn:BSU30370" /db_xref="EnsemblGenomes-Tr:CAB15015" /db_xref="GOA:O34741" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG13921" /db_xref="UniProtKB/Swiss-Prot:O34741" /translation="MNINQLILRNLKKNLRNYYLYVFALIFSVALYFAFVTLQYDPAI NEVKASIKGAAAIKTASILLVAVVAIFILYANTIFIKRRSKEIGLFQLIGMTKHKIFR ILSAENVMLYFGSLAIGVAAGFSISKLVLMILFKIVDVKADAKLHFSEQALVQTVIVF CGIYLLIMIMNYTFIKKQSILSLFKVTSSTEDKVKKISFFQMLIGALGIVLILTGYYV SSELFGGKFKTINELFVAMSFILGSVIIGTFLFYKGSVTFISNIIRKSKGGYLNISEV LSLSSIMFRMKSNALLLTIITTVSALAIGLLSLAYISYYSSEKTAEQNVAADFSFMNE KDAKLFENKLRESNISFVKKATPVLQANVDIANIMDGTPKEMQGDPGNMQLAVVSDKD VKGVDVAAGEAVFSGYTDLLQKIMVFKDSGVIKVKSKHETQPLKYKGLREEFLVSYTF TSGGMPAVIVDDSLFKQLDKDKDPRIQLAQSTFIGVNVKHDDQMEKANELFQQVNKKN EHLSRLDTSAAQKSLFGMVMFIVGFLGLTFLITSGCILYFKQMGESEDEKPSYTILRK LGFTQGDLIKGIRIKQMYNFGIPLVVGLFHSYFAVQSGWFLFGSEVWAPMIMVMVLYT ALYSIFGFLSVLYYKKVIKSSL*" /label="bceB CDS" gene complement(2545294..2547234) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /label="bceB gene" downshifts complement(2545305) /Source="Nicolas_upshifts" /id="D1565" /incds=0 /nref=13 /ntot=89 /MaxReadThrough="1.56566" /MaxDrop="4.45006" /score="29.4802229" /energy="-11.6" /TU="NA" /idTUdmin="U2356" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2547224..2547985) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14612242, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 17905982, 25118291; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacitracin ABC efflux transporter (ATP-binding protein)" /protein_id="NP_390916.1" /db_xref="EnsemblGenomes-Gn:BSU30380" /db_xref="EnsemblGenomes-Tr:CAB15016" /db_xref="GOA:O34697" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13920" /db_xref="UniProtKB/Swiss-Prot:O34697" /translation="MVILEANKIRKSYGNKLNKQEVLKGIDIHIEKGEFVSIMGASGS GKTTLLNVLSSIDQVSHGTIHINGNDMTAMKEKQLAEFRKQHLGFIFQDYNLLDTLTV KENILLPLSITKLSKKEANRKFEEVAKELGIYELRDKYPNEISGGQKQRTSAGRAFIH DPSIIFADEPTGALDSKSASDLLNKLSQLNQKRNATIIMVTHDPVAASYCGRVIFIKD GQMYTQLNKGGQDRQTFFQDIMKTQGVLGGVQHEH*" /label="bceA CDS" gene complement(2547224..2547985) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /label="bceA gene" misc_feature complement(2548009..2548027) /Source="Nicolas_upshift_promotors" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2548028) /Source="Nicolas_upshifts" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2548087..2549091) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase controlling resistance to antibiotics affecting the envelope [YtsA]" /protein_id="NP_390917.1" /db_xref="EnsemblGenomes-Gn:BSU30390" /db_xref="EnsemblGenomes-Tr:CAB15017" /db_xref="GOA:O35044" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13919" /db_xref="UniProtKB/Swiss-Prot:O35044" /translation="MIKAFLIERRSWIAAFLFQQALMLFIAFVDPSISFGNVLYMVYL CILFFIIFLWFRYRKETAFYKSLKTWENNLDVTAINEPETPFEAMVERSIAGQTEHLK QTAARHRLALENEKDELMAWIHEVKTPLTAMHLIIDRMEEKALKSQLSYEWLRIHLLL DQQLHQKRISFIENDLSVEFIQLQPLIFKEIKDLQSWCIQKGIGFDIQLEAKEVLSDA KWLAFIIRQLLTNAVKYSEASEIEIKSFQKGEQTQLQVKDCGRGIDPKDVPRIFDKGF TSTTDHHDQASTGMGLYLAKKAAAPLLIHIDVESEFGAGTVFTLTFPIRNQFEHVISV *" /label="bceS CDS" gene complement(2548087..2549091) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /label="bceS gene" downshifts complement(2548126) /Source="Nicolas_upshifts" /id="D1566" /incds=0 /nref=25 /ntot=187 /MaxReadThrough="2.40611" /MaxDrop="4.6482" /score="29.3236847" /energy="-13.9" /TU="NA" /idTUdmin="U2357" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2549084..2549779) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator controlling resistance to antibiotics affecting the envelope [YtsB]" /protein_id="NP_390918.1" /db_xref="EnsemblGenomes-Gn:BSU30400" /db_xref="EnsemblGenomes-Tr:CAB15018" /db_xref="GOA:O34951" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12340" /db_xref="UniProtKB/Swiss-Prot:O34951" /translation="MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAV NPDCVIIDVQLPKFDGFHWCRLIRSRSNVPILFLSSRDHPADMVMSMQLGADDFIQKP FHFDVLIAKIQAMFRRVHHYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFI LKQLIEQKNKIVSREELIRSLWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVG QGYIAKEEDKFYD*" /label="bceR CDS" gene complement(2549084..2549779) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /label="bceR gene" promotor_-10 complement(2549803..2549821) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2549815) /Source="Nicolas_upshifts" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2549837..2549840) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2549876..2551186) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="metabolite permease involved in resistance to cell wall inhibitors" /protein_id="NP_390919.1" /db_xref="EnsemblGenomes-Gn:BSU30410" /db_xref="EnsemblGenomes-Tr:CAB15019" /db_xref="GOA:O35005" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13916" /db_xref="UniProtKB/Swiss-Prot:O35005" /translation="MRFKDQVHFIRRNMKKNRLRVFMTILATTMACAFLVVLSSVGFG IQKTITDMTMSQQIVTKVSVMGKEGDKPIKKADLEKYDHVRSVVERTQVYEPNKATLG NRTNESSNLIFTNMNDELKANMELEKGRVAKSENEIVVGYDFAKRLLTKKESEEYNKK IEEAKGNPEDIKEPKGYTKDILNKTIELSVSKTDSKTGDVTKTKTYDFKIVGITKKPS QDWMEDSNIFISDQFKKDFSEFLDFKGGNVETNIGVFADKFENVEQLTNDLTDDGYYV TSVTTELEGANTFFMVFKIGLIFVGCIAVIISAIGIFNTMTMAVTERTQEIGIMKAIG ASPSIIRRMFLMESAYIGILGCVIGIIISYGVSYLVNLAVPMILAATSGGDAGDLNYT FSYIPASLVIIAVVICGGVAVISGMNPARKATKTNVLTALRREL*" /label="ytrF CDS" gene complement(2549876..2551186) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /label="ytrF gene" downshifts complement(2549898) /Source="Nicolas_upshifts" /id="D1567" /incds=0 /nref=9 /ntot=170 /MaxReadThrough="4.26891" /MaxDrop="3.83905" /score="28.2472037" /energy="-13.6" /TU="U2359" /idTUdmin="U2359" /TUdmin="-1755" /isTUend="FALSE" /label="downshifts" CDS complement(2551176..2551871) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22720735, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22720735, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390920.1" /db_xref="EnsemblGenomes-Gn:BSU30420" /db_xref="EnsemblGenomes-Tr:CAB15020" /db_xref="GOA:O34392" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13915" /db_xref="UniProtKB/Swiss-Prot:O34392" /translation="MIDVQHIDHSFTIGKKGRENEVPVLKDVSLSVAKGEIACIVGRS GSGKSTLLNLISGYISPTKGRIVINGTDVTGFNEKEWAQFRLDHFGFIFQSFQLIPGL TTYENVEMPLALKGIKPSERKQKVQDMLKRVGLENHAAHYPNELSGGQQQRVSIARAL ILNPSIILADEPTGSLDSETEHEVLELIQQLNRERGITFVIITHDDEVASIGHSKFQL HDGVLKGGITVEV*" /label="ytrE CDS" gene complement(2551176..2551871) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /label="ytrE gene" CDS complement(2551886..2552863) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390921.1" /db_xref="EnsemblGenomes-Gn:BSU30430" /db_xref="EnsemblGenomes-Tr:CAB15021" /db_xref="GOA:O34953" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13914" /db_xref="UniProtKB/Swiss-Prot:O34953" /translation="MPDSGLLYKEWRQNKVALVITILVFILGNPLSILNMYLIYQGCV TGKENWVGPCVFSVDYLNSSFISLFWIWGVVLAVSQLGIERSKSFFDFTLSLPYTRGQ IFHAKFLTGGMVIVVPQLIGYVLSVLLIMLLKPDQAVYFHNYSLGMIIVSMLAYSLVM AGGALTGNSFAQLLVSFTVAISPFLLISLPVINLEILFGGSIDFIHGPVPKWVQYFIP IIYVDSKWAENSPYYLVIPAIMTIIFYIIGYISFVKMSNERNGYFFLWKPLNRPVQII VIIIGIMGFGYFGFTASESFAGYLIGMGTGAVIGFLISYFAIYKKMKLL*" /label="ytrD CDS" gene complement(2551886..2552863) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /label="ytrD gene" CDS complement(2552893..2553879) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390922.1" /db_xref="EnsemblGenomes-Gn:BSU30440" /db_xref="EnsemblGenomes-Tr:CAB15022" /db_xref="GOA:O34898" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13913" /db_xref="UniProtKB/Swiss-Prot:O34898" /translation="MVDRGLLYREWKQNQVVILLSIAFLVLANPLSIVNTYLSYQGCL DRQDPQYCDFIVNYSISNLIDINWVPGVILAVCFLGMERSKGTMDFILSLPYNRSQIF QTKFWLGGFVIVLSQLIGFLLAWLLILVYNPEHVYFFEHSSIGVIVISFMAFSLVMAA GALTGNAFAQLLTAFSAAILPYLIIALPVGNLEVVFGANIWEIFPSPESYFSLASNLS NLVPISYVVNEWLINSKYLLLIPAVMSMLFYLIGFISFKKLPSERNGHFFLWNRLDRP VQILVMAFGILGFGLFGYYTGHSIIGYILGMIIGAVAGFFVSYFSIYKKTKV*" /label="ytrC CDS" gene complement(2552893..2553879) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /label="ytrC gene" promotor_-35 2553749..2553758 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2553765 /Source="Nicolas_upshifts" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2553771..2553786 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2553873..2554751) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390923.1" /db_xref="EnsemblGenomes-Gn:BSU30450" /db_xref="EnsemblGenomes-Tr:CAB15023" /db_xref="GOA:O34641" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13912" /db_xref="UniProtKB/Swiss-Prot:O34641" /translation="MIELRQLSKAIDGNQVLKDVSLTIEKGEIFGLLGRNGSGKTTML RLIQQIIFADSGTILFDGVEIKKHPKVKQNIIYMPVQNPFYDKYTYKQLVDILRRIYP KFDVTYANELMNRYEIPETKKYRELSTGLKKQLSLVLSFAARPALILLDEPTDGIDAV TRHDVLQLMVDEVAERDTSILITSHRLEDIERMCNRIGFLEDNSLTNVMDLDELKEEY IKIQMAFDTDVNLAIREQNIPMLDQAGVFYTVLIPKSDEEKKSFLRELKPKVWNELPV NLEEVFIAKFGGKRRW*" /label="ytrB CDS" gene complement(2553873..2554751) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /label="ytrB gene" CDS complement(2554744..2555136) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986249, 11756427, 17194626, 21856850, 28357385" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 11756427, 17194626, 21856850, 28357385; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family, cell wall antibiotics)" /protein_id="NP_390924.1" /db_xref="EnsemblGenomes-Gn:BSU30460" /db_xref="EnsemblGenomes-Tr:CAB15024" /db_xref="GOA:O34712" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13911" /db_xref="UniProtKB/Swiss-Prot:O34712" /translation="MIQIDPRSSTPIYEQIIQQMKELCLKGIMKPGDKLPSVRELATI IIANPNTVSKAYKELEREGIIETLRGRGTYISENAKTTLVEGKMTMIKEQLKQLIIDA HYAGVELEKLHEWIKEISADVKGGKKND*" /label="ytrA CDS" gene complement(2554744..2555136) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /label="ytrA gene" S_feature complement(2555137..2555381) /Source="Nicolas_S_feature" /locus_tag="new_3119240_3119484_c" /HighExp="Cold, Salt, SMMPr, MG 15, M9-tran, G180, M9-exp, M/G, MG 25, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.71885600000000005" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1162" CDS complement(2555170..2555307) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28357385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513999.1" /db_xref="EnsemblGenomes-Gn:BSU30466" /db_xref="EnsemblGenomes-Tr:CCQ48604" /db_xref="GOA:L8ECR1" /db_xref="UniProtKB/TrEMBL:L8ECR1" /translation="MKHKKRNKRNVPMLIAASVIACSFFLVLVMIGFEWQKSIIDHFY L*" /label="conserved protein of unknown function CDS" gene complement(2555170..2555307) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /label="gene" downshifts 2555305 /Source="Nicolas_upshifts" /id="D1568" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.62989" /MaxDrop="3.1332" /score="6.69010243" /energy="-14.4" /TU="NA" /idTUdmin="U2361" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2555376..2555395) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2555381) /Source="Nicolas_upshifts" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2555409..2555416) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2555462..2555734) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390925.1" /db_xref="EnsemblGenomes-Gn:BSU30470" /db_xref="EnsemblGenomes-Tr:CAB15025" /db_xref="InterPro:IPR019668" /db_xref="SubtiList:BG13937" /db_xref="UniProtKB/Swiss-Prot:O32073" /translation="MATRQSVDEHLQQCMQAYDYAEEQLKIASKQEHYNDQEYSDAQM QLEDAVNALNKLWLSSNDQQREQLYRMRLQLQSLQNNMILQHPLDV*" /label="ytzC CDS" gene complement(2555462..2555734) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /label="ytzC gene" downshifts complement(2555469) /Source="Nicolas_upshifts" /id="D1569" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.96566" /MaxDrop="8.4811" /score="36.3100501" /energy="-14.4" /TU="NA" /idTUdmin="U2360" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2555774..2555785) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2555778..2555786 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2555778) /Source="Nicolas_upshifts" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="upshifts" upshifts 2555789 /Source="Nicolas_upshifts" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2555800..2555806) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2555800..2555818 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2555829..2555834 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2555848..2555867 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2555855 /Source="Nicolas_upshifts" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="upshifts" CDS 2555896..2556864 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10413665; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_390926.1" /db_xref="EnsemblGenomes-Gn:BSU30480" /db_xref="EnsemblGenomes-Tr:CAB15026" /db_xref="GOA:O35008" /db_xref="InterPro:IPR005911" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032432" /db_xref="SubtiList:BG13908" /db_xref="UniProtKB/Swiss-Prot:O35008" /translation="MMQNNPFPYSNTEKRYHTLNYHLREHFGHKVFKVALDGGFDCPN RDGTVAHGGCTFCSAAGSGDFAGNRTDDLITQFHDIKNRMHEKWKDGKYIAYFQAFTN THAPVEVLREKFESVLALDDVVGISIATRPDCLPDDVVDYLAELNERTYLWVELGLQT VHERTALLINRAHDFNCYVEGVNKLRKHGIRVCSHIINGLPLEDRDMMMETAKAVADL DVQGIKIHLLHLLKGTPMVKQYEKGKLEFLSQDDYVQLVCDQLEIIPPEMIVHRITGD GPIELMIGPMWSVNKWEVLGAINKELENRGSYQGKFFQRLEEESAL*" /label="ytqA CDS" gene 2555896..2556864 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /label="ytqA gene" CDS 2556861..2557445 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24699744; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methylase" /protein_id="NP_390927.1" /db_xref="EnsemblGenomes-Gn:BSU30490" /db_xref="EnsemblGenomes-Tr:CAB15027" /db_xref="GOA:O34614" /db_xref="InterPro:IPR010719" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13909" /db_xref="UniProtKB/Swiss-Prot:O34614" /translation="MILKKILPYSKELLKMAAGEGDIVVDATMGNGHDTQFLAELVGE NGHVYAFDIQESAVANTKERLGDMYQARTTLFHKSHDKIAESLPPETHGKVAAAVFNL GYLPGGDKSITTNGSSTIKAIEQLLSIMKDEGLIVLVVYHGHPEGKAEKNDVLEFCRD LDQQTARVLTYGFINQQNDPPFIVAIEKKAQISK*" /label="ytqB CDS" gene 2556861..2557445 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /label="ytqB gene" downshifts 2557409 /Source="Nicolas_upshifts" /id="D1570" /incds=0 /nref=58 /ntot=249 /MaxReadThrough="2.35311" /MaxDrop="4.47418" /score="22.0352465" /energy="-11.9" /TU="NA" /idTUdmin="U2362" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2557435..>2557566) /gene="tbcS" /locus_tag="IIG_Bs13_pseudo_BSU_30500" /old_locus_tag="BSU_30500" /EC_number="4.2.3.130" /experiment="publication(s) with functional evidences, PMID:21627333, 24806199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21627333, 24806199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetraprenyl-beta-curcumene synthase" /protein_id="NP_390928.1" /db_xref="EnsemblGenomes-Gn:BSU30500" /db_xref="EnsemblGenomes-Tr:CAB15028" /db_xref="GOA:O34707" /db_xref="InterPro:IPR019712" /db_xref="SubtiList:BG13901" /db_xref="UniProtKB/Swiss-Prot:O34707" /modified_by="User" /translation="LAKKLIKASGKTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC* " /label="IIG_Bs13_pseudo_BSU_30500" gene complement(2557435..>2557566) /gene="tbcS" /locus_tag="IIG_Bs13_pseudo_BSU_30500" /old_locus_tag="BSU_30500" /modified_by="User" /label="IIG_Bs13_pseudo_BSU_30500" downshifts complement(2557476) /Source="Nicolas_upshifts" /id="D1571" /incds=0 /nref=35 /ntot=240 /MaxReadThrough="3.47268" /MaxDrop="4.45295" /score="16.7564664" /energy="-10.1" /TU="U2364" /idTUdmin="U2365" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" SCAR 2557569..2557570 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs13" S_feature complement(<2557570..2557585) /Source="Nicolas_S_feature" /locus_tag="new_3123442_3124021_c" /HighExp="dia15, H2O2, Diami, Salt, dia5, M0t90, Lbstat, Etha, Paraq, Lbtran" /AntisenseName="ytoA" /AntisenseCor="-0.44861767737485803" /AntisenseRegPval="-14" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1163" promotor_-10 complement(2557576..2557595) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2557585) /Source="Nicolas_upshifts" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2557587..2557721) /Source="Nicolas_S_feature" /locus_tag="new_3124023_3124157_c" /HighExp="LoTm, Cold, dia5, dia15, Diami, H2O2, S7, G135, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1164" promotor_-35 complement(2557607..2557614) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2557696..2557715) /Source="Nicolas_upshift_promotors" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2557721) /Source="Nicolas_upshifts" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2557814..2559205) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_390931.1" /db_xref="EnsemblGenomes-Gn:BSU30530" /db_xref="EnsemblGenomes-Tr:CAB15031" /db_xref="GOA:O34618" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG13891" /db_xref="UniProtKB/Swiss-Prot:O34618" /translation="MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPG ILVAYAASGLVMFFIMRALGEMAIQKPVAGSFSRYARDYLGPLAGYLTGWNYWFLWVV TCMAEITAVGIYMGFWFPDVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVA ILSMIAVGLLMIIAGVGNGGIATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEM IGVTAGEVKNPQKSLAKAIDTVFWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQ KVGIPSAAGIINFVVLTAALSSCNSGIFSTGRMLFNLAEQKEAPQAYGQLTKGGIPGK AVLASAGALLVGVLLNYVVPAKVFTWVTSIATFGAIWTWAIILLSQIKYRKSLKPEEK KQLKYKMPLFPFTSYVSLAFLAFVVILMAYSPDTRVAVIIGPIWFLILLAVYYGKGFH KKNAAAASERNIS*" /label="ytnA CDS" gene complement(2557814..2559205) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /label="ytnA gene" downshifts complement(2557822) /Source="Nicolas_upshifts" /id="D1572" /incds=0 /nref=133 /ntot=225 /MaxReadThrough="3.05784" /MaxDrop="5.43778" /score="3.82664462" /energy="-7.5" /TU="U2368" /idTUdmin="U2368" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(2559206..2559340) /Source="Nicolas_S_feature" /locus_tag="new_3125642_3125776_c" /HighExp="Oxctl, Paraq, Heat, Lbexp, G150, S0, dia0, H2O2, G180, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1165" CDS complement(2559341..2561239) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /EC_number="2.4.-.-" /EC_number="6.3.5.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 21949063, 28317238" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 21949063, 28317238; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-diaminopimelic acid amidotransferase (asparagine synthetase)" /protein_id="NP_390932.1" /db_xref="EnsemblGenomes-Gn:BSU30540" /db_xref="EnsemblGenomes-Tr:CAB15032" /db_xref="GOA:P54420" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11831" /db_xref="UniProtKB/Swiss-Prot:P54420" /translation="MCGFVGVFNKHPLAQTADQEELIKQMNQMIVHRGPDSDGYFHDE HVGFGFRRLSIIDVENGGQPLSYEDETYWIIFNGEIYNYIELREELEAKGYTFNTDSD TEVLLATYRHYKEEAASKLRGMFAFLIWNKNDHVLYGARDPFGIKPLYYTTINDQVYF ASERKSLMVAQNDIEIDKEALQQYMSFQFVPEPSTLDAHVKKVEPGSQFTIRPDGDIT FKTYFKANFKPVQTEEDKLVKEVRDAIYDSVNVHMRSDVPVGSFLSGGIDSSFIVSVA KEFHPSLKTFSVGFEQQGFSEVDVAKETAAALGIENISKVISPEEYMNELPKIVWHFD DPLADPAAIPLYFVAKEAKKHVTVALSGEGADELFGGYNIYREPLSLKPFERIPSGLK KMLLHVAAVMPEGMRGKSLLERGCTPLQDRYIGNAKIFEESVKKQLLKHYNPNLSYRD VTKTYFTESSSYSDINKMQYVDIHTWMRGDILLKADKMTMANSLELRVPFLDKVVFDV ASKIPDELKTKNGTTKYLLRKAAEGIVPEHVLNRKKLGFPVPIRHWLKNEMNEWVRNI IQESQTDAYIHKDYVLQLLEDHCADKADNSRKIWTVLIFMIWHSINIEKRYMPEELSH QPKEVIFV*" /label="asnB CDS" gene complement(2559341..2561239) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /label="asnB gene" promotor_-35 2560397..2560403 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2560418..2560429 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2560430 /Source="Nicolas_upshifts" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2561240..2561363) /Source="Nicolas_S_feature" /locus_tag="new_3127676_3127799_c" /HighExp="Paraq, G135, G180, G150, Oxctl, LBGexp, BMM, dia0, Heat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.632, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1166" CDS complement(2561389..2562591) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /EC_number="2.5.1.6" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16672621, 18634909" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16672621, 18634909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine synthetase" /protein_id="NP_390933.1" /db_xref="EnsemblGenomes-Gn:BSU30550" /db_xref="EnsemblGenomes-Tr:CAB15033" /db_xref="GOA:P54419" /db_xref="InterPro:IPR002133" /db_xref="InterPro:IPR022628" /db_xref="InterPro:IPR022629" /db_xref="InterPro:IPR022630" /db_xref="InterPro:IPR022631" /db_xref="InterPro:IPR022636" /db_xref="SubtiList:BG11840" /db_xref="UniProtKB/Swiss-Prot:P54419" /translation="MSKNRRLFTSESVTEGHPDKICDQISDSILDEILKKDPNARVAC ETSVTTGLVLVSGEITTSTYVDIPKTVRQTIKEIGYTRAKYGFDAETCAVLTSIDEQS ADIAMGVDQALEAREGTMSDEEIEAIGAGDQGLMFGYACNETKELMPLPISLAHKLAR RLSEVRKEDILPYLRPDGKTQVTVEYDENNKPVRIDAIVISTQHHPEITLEQIQRNIK EHVINPVVPEELIDEETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGA FSGKDATKVDRSAAYAARYVAKNIVAAELADSCEVQLAYAIGVAQPVSISINTFGSGK ASEEKLIEVVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRHDVDLPWERTDKAEQ LRKEALGE*" /label="metK CDS" gene complement(2561389..2562591) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /label="metK gene" downshifts complement(2561408) /Source="Nicolas_upshifts" /id="D1573" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="7.14538" /MaxDrop="3.78097" /score="-4.044113" /energy="-12.1" /TU="U2367,U2368" /idTUdmin="U2367" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2562634..2562645) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2562640) /Source="Nicolas_upshifts" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2562642..2562758) /Source="Nicolas_S_feature" /locus_tag="new_3129078_3129194_c" /HighExp="G180, Paraq, G150, Oxctl, G135, BMM, LBGexp, HPh, MG-0.2, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1167" promotor_-35 complement(2562659..2562665) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2562759..2562897) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswG RNA" gene complement(2562759..2562897) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /label="mswG gene" downshifts 2562857 /Source="Nicolas_upshifts" /id="D1574" /incds=0 /nref=3 /ntot=20 /MaxReadThrough="1.15866" /MaxDrop="4.97875" /score="11.8729615" /energy="-16.6" /TU="NA" /idTUdmin="U2369" /TUdmin="-1841" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2562906..2562925) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-10" upshifts complement(2562921) /Source="Nicolas_upshifts" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="upshifts" promotor_-35 complement(2562942..2562946) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-35" promotor_-35 2563018..2563025 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2563037 /Source="Nicolas_upshifts" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2563039..2563058 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2563094..2564677 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /EC_number="4.1.1.49" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400158, 4146915, 15491857, 15720552, 18586936, 20933603, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoenolpyruvate carboxykinase" /protein_id="NP_390934.2" /db_xref="EnsemblGenomes-Gn:BSU30560" /db_xref="EnsemblGenomes-Tr:CAB15034" /db_xref="GOA:P54418" /db_xref="InterPro:IPR001272" /db_xref="InterPro:IPR008210" /db_xref="InterPro:IPR013035" /db_xref="InterPro:IPR015994" /db_xref="SubtiList:BG11841" /db_xref="UniProtKB/Swiss-Prot:P54418" /translation="MNSVDLTADLQALLTCPNVRHNLSAAQLTEKVLSRNEGILTSTG AVRATTGAYTGRSPKDKFIVEEESTKNKIDWGPVNQPISEEAFERLYTKVVSYLKERD ELFVFEGFAGADEKYRLPITVVNEFAWHNLFARQLFIRPEGNDKKTVEQPFTILSAPH FKADPKTDGTHSETFIIVSFEKRTILIGGTEYAGEMKKSIFSIMNFLLPERDILSMHC SANVGEKGDVALFFGLSGTGKTTLSADADRKLIGDDEHGWSDTGVFNIEGGCYAKCIH LSEEKEPQIFNAIRFGSVLENVVVDEDTREANYDDSFYTENTRAAYPIHMINNIVTPS MAGHPSAIVFLTADAFGVLPPISKLTKEQAMYHFLSGYTSKLAGTERGVTSPETTFST CFGSPFLPLPAHVYAEMLGKKIDEHGADVFLVNTGWTGGGYGTGERMKLSYTRAMVKA AIEGKLEDAEMITDDIFGLHIPAHVPGVPDHILQPENTWTNKEEYKEKAVYLANEFKE NFKKFAHTDAIAQAGGPLV*" /label="pckA CDS" gene 2563094..2564677 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /label="pckA gene" downshifts 2564666 /Source="Nicolas_upshifts" /id="D1575" /incds=0 /nref=106 /ntot=269 /MaxReadThrough="2.55056" /MaxDrop="8.3695" /score="11.8729615" /energy="-16.6" /TU="U2369" /idTUdmin="U2369" /TUdmin="-32" /isTUend="FALSE" /label="downshifts" CDS complement(2564716..2564958) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390935.1" /db_xref="EnsemblGenomes-Gn:BSU30570" /db_xref="EnsemblGenomes-Tr:CAB15035" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019699" /db_xref="PDB:2NWA" /db_xref="SubtiList:BG13882" /db_xref="UniProtKB/Swiss-Prot:O34365" /translation="MGMPVEFNTLIVTKGKEVRIDENIFTLEKDGYRVYPMEIPMDVR KTKFGEKSGTAEVQKLQWEEGRTIITYKLTSLHSVN*" /label="ytmB CDS" gene complement(2564716..2564958) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /label="ytmB gene" downshifts complement(2564730) /Source="Nicolas_upshifts" /id="D1576" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="1.2088" /MaxDrop="5.1365" /score="38.3436505" /energy="-16.6" /TU="NA" /idTUdmin="U2371" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2565010..2565783) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27899916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative esterase" /protein_id="NP_390936.1" /db_xref="EnsemblGenomes-Gn:BSU30580" /db_xref="EnsemblGenomes-Tr:CAB15036" /db_xref="GOA:O34493" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13881" /db_xref="UniProtKB/Swiss-Prot:O34493" /translation="MIVEKRRFPSPSQHVRLYTICYLSNGLRVKGLLAEPAEPGQYDG FLYLRGGIKSVGMVRPGRIIQFASQGFVVFAPFYRGNQGGEGNEDFAGEDREDAFSAF RLLQQHPNVKKDRIHIFGFSRGGIMGMLTAIEMGGQAASFVSWGGVSDMILTYEERQD LRRMMKRVIGGTPKKVPEEYQWRTPFDQVNKIQAPVLLIHGEKDQNVSIQHSYLLEEK LKQLHKPVETWYYSTFTHYFPPKENRRIVRQLTQWMKNR*" /label="ytmA CDS" gene complement(2565010..2565783) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /label="ytmA gene" S_feature complement(2565784..2565874) /Source="Nicolas_S_feature" /locus_tag="new_3132220_3132310_c" /HighExp="S8, dia15, Diami, Etha, S7, dia5, H2O2, G180, Heat, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1168" promotor_-35 2565850..2565859 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2565863..2565882) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2565871 /Source="Nicolas_upshifts" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2565872..2565891 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2565876) /Source="Nicolas_upshifts" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2565897..2565904) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2565934..2566938 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component" /protein_id="NP_390937.2" /db_xref="EnsemblGenomes-Gn:BSU30595" /db_xref="EnsemblGenomes-Tr:CAB15037" /db_xref="GOA:C0SP84" /db_xref="SubtiList:BG13873" /db_xref="UniProtKB/Swiss-Prot:C0SP84" /translation="MNRWLRLGFACVGSIFLMFALAACKQEETLTKVKVAEVTHSIFY APLYVAESKGFFKEEGLDVDVNTTWGGDKTMTSLLSNGSDIALVGSETSIYVEAQGAK DPVINFAQLTQTDGTFLVAREDVEHFDWDQLKGKTFLGQRKGGMPQMVGEYVLNKHKI DPHKDIDLIQNIDFANIANAFASGTGEYVQLFEPQASLFEKKGIGHIVASFGEESGEV PYTTFMAKQSYLKKNEDTAVKFTKAIYKAQQWVENHSAKDITDAIKDEFDDTDPDVIE TSIERYKKQHSYSPDPLLNEKEWELLQTIMDKSGELPKHIPYNQLVNKEIAEKVTSEK *" /label="ytlA CDS" gene 2565934..2566938 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /label="ytlA gene" CDS 2566951..2567733 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component, ATP-binding" /protein_id="NP_390939.1" /db_xref="EnsemblGenomes-Gn:BSU30610" /db_xref="EnsemblGenomes-Tr:CAB15039" /db_xref="GOA:O34314" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13875" /db_xref="UniProtKB/Swiss-Prot:O34314" /translation="MSFLHVDHVTHTYFSIKEKTTAVRDIHFDAEKGDFISFLGPSGC GKTTLLSIIAGLIEPSEGRVLIEGREPNQKEHNIGYMLQQDYLFPWKSIEENVLLGLK IADTLTEESKAAALGLLPEFGLIDVEKKYPKELSGGMRQRAALARTLAPNPSLLLLDE PFSALDFQTKLSLENLVFRTLKEYQKTAVLVTHDIGEAIAMSDTIFLFSNQPGTIHQI FTIPKELAAMLPFDARQEPSFQTLFQTIWKELNSLEKQQRNH*" /label="ytlC CDS" gene 2566951..2567733 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /label="ytlC gene" S_feature complement(2566955..2568503) /Source="Nicolas_S_feature" /locus_tag="new_3133391_3134939_c" /HighExp="Cold, S8, G180, H2O2, G135, Paraq, G150, S7, Oxctl, LPh" /AntisenseName="ytlC" /AntisenseCor="0.110169300738282" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1169" CDS 2567708..2568520 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease of ABC anion transporter" /protein_id="NP_390940.1" /db_xref="EnsemblGenomes-Gn:BSU30620" /db_xref="EnsemblGenomes-Tr:CAB15040" /db_xref="GOA:O34649" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13876" /db_xref="UniProtKB/Swiss-Prot:O34649" /translation="MRNSKETIDLLHEQYQFKQKKEKWKVHSFQLAIFILFFSGWEIS SRQGWIDPLIFSSPSAVWRLLLEKLGDGSLLSHIGVTLFETVLGFLLGTFMGTCLAAL LWWSNRLARILDPYLVILNAMPKVALGPILIVALGPSFISIIAMGAIISVIITTIVVY TAFQEVDENYTKVMKTFGAKKWVIFKEVILPASSPAIISTLKVNVGLSWVGVIVGEFL VSKVGLGYMIIYGFQVFNFTLVFLSLLIIAIFATLMYQGVELLEKKWTKGRT*" /label="ytlD CDS" gene 2567708..2568520 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /label="ytlD gene" downshifts 2568505 /Source="Nicolas_upshifts" /id="D1577" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="3.58734" /MaxDrop="4.596" /score="38.1379668" /energy="-12.6" /TU="U2370" /idTUdmin="U2370" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(2568547..2569023) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /EC_number="3.6.1.15" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576788, 16513759, 21925382, 23610407, 23610425, 27936487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576788, 16513759, 21925382, 23610407, 23610425, 27936487; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nucleoside and RNA triphosphate phosphohydrolase" /protein_id="NP_390941.1" /db_xref="EnsemblGenomes-Gn:BSU30630" /db_xref="EnsemblGenomes-Tr:CAB15041" /db_xref="GOA:O35013" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR014078" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="PDB:4JZS" /db_xref="PDB:4JZT" /db_xref="PDB:4JZU" /db_xref="PDB:4JZV" /db_xref="SubtiList:BG13869" /db_xref="UniProtKB/Swiss-Prot:O35013" /translation="MYEFKDYYQNTVQLSFDDQPFSDSPKHVWVICRFGGKWLLTEHE DRGYEFPGGKVEPMECAEEAALREVKEETGARVKSLKYLGQYKVLGKEKVIVKNIYFA DIEKLEKQADYFETKGPVLFHELPENLSRNKKFSFIMKDSVLPISLKKLKESGWIE*" /label="rppG CDS" gene complement(2568547..2569023) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /label="rppG gene" downshifts complement(2568548) /Source="Nicolas_upshifts" /id="D1578" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.52721" /MaxDrop="6.99686" /score="36.2618206" /energy="-12.6" /TU="U2372" /idTUdmin="U2373" /TUdmin=11 /isTUend="TRUE" /label="downshifts" misc_feature complement(2569053..2569072) /Source="Nicolas_upshift_promotors" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2569066) /Source="Nicolas_upshifts" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2569068..2569202) /Source="Nicolas_S_feature" /locus_tag="new_3135504_3135638_c" /HighExp="BT, B36, S8, S5, S7, Etha, S6, S4, B60, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK, SigB" /TUshortPSig="0.909, 1, 0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1170" upshifts complement(2569202) /Source="Nicolas_upshifts" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2569204..2569215) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2569230..2569236) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2569232..2569636) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative autolytic amidase" /protein_id="NP_390942.1" /db_xref="EnsemblGenomes-Gn:BSU30640" /db_xref="EnsemblGenomes-Tr:CAB15042" /db_xref="GOA:O34883" /db_xref="InterPro:IPR006480" /db_xref="SubtiList:BG13868" /db_xref="UniProtKB/Swiss-Prot:O34883" /translation="MDRDFGIFSFLAVSVSAAGFFFGGFQYSFLILLSLMAIEFISTT LKETIIHKLSFKKVFARLVKKLVTLALISVCHFFDQLLNTQGSIRDLAIMFYILYESV QIVVTASSLGIPVPQMLVDLLETLKNKFKRKP*" /label="ytkC CDS" gene complement(2569232..2569636) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /label="ytkC gene" promotor_-10 complement(2569664..2569683) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2569681) /Source="Nicolas_upshifts" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2569683..2569769) /Source="Nicolas_S_feature" /locus_tag="new_3136119_3136205_c" /HighExp="Etha, B36, S8, B60, S7, LoTm, Salt, Sw, Gly, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1171" promotor_-35 complement(2569696..2569705) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2569802..2570239) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12767829, 16091047, 16861227, 16935006; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-protecting protein, mini-ferritin" /protein_id="NP_390943.1" /db_xref="EnsemblGenomes-Gn:BSU30650" /db_xref="EnsemblGenomes-Tr:CAB15043" /db_xref="GOA:P80879" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="SubtiList:BG12584" /db_xref="UniProtKB/Swiss-Prot:P80879" /translation="MSEQLIQAVNKQVANWTVMYVKLHNYHWYVKGKDFFTLHEKFEE LYNETATYIDDLAERLLALNGKPIATMKESLETASVKEAAGNETAEQMVQSVYDDFTV IAEELKNGMDLADEVGDETTGDMLLAIHQNIEKHNWMLKAYLG*" /label="dps CDS" gene complement(2569802..2570239) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /label="dps gene" downshifts complement(2569814) /Source="Nicolas_upshifts" /id="D1579" /incds=0 /nref=188 /ntot=382 /MaxReadThrough="3.87056" /MaxDrop="7.83664" /score="36.0931083" /energy="-19.2" /TU="U2375" /idTUdmin="U2377" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2570256..2570274) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2570274) /Source="Nicolas_upshifts" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2570276..2570501) /Source="Nicolas_S_feature" /locus_tag="new_3136712_3136937_c" /HighExp="M0t90, Lbstat, M40t90, ferm, S2, nit, M40t45, S0, Lbtran, BT" /AntisenseName="ytzI" /AntisenseCor="-0.30531150128448598" /AntisenseRegPval="-6.5" /CDS_PredictionProba="0.38276900000000003" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1172" promotor_-35 complement(2570289..2570295) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2570331..2570350 /Source="Nicolas_upshift_promotors" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2570332..2570508 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097774.1" /db_xref="EnsemblGenomes-Gn:BSU30659" /db_xref="EnsemblGenomes-Tr:CAX52680" /db_xref="GOA:C0H3Q1" /db_xref="InterPro:IPR022248" /db_xref="UniProtKB/Swiss-Prot:C0H3Q1" /translation="MLQLLKNGRWNVMTLLITISILIVLAVLLVTIWTTVKAYNVKHT IDPPQENHSDSHNQ*" /label="ytzI CDS" gene 2570332..2570508 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /label="ytzI gene" upshifts 2570333 /Source="Nicolas_upshifts" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2570502..2570939) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390944.1" /db_xref="EnsemblGenomes-Gn:BSU30660" /db_xref="EnsemblGenomes-Tr:CAB15044" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR032693" /db_xref="SubtiList:BG11027" /db_xref="UniProtKB/Swiss-Prot:P40768" /translation="MKKMLVVLLFSALLLNGCGSGESKANTAETPEVLDVKLTGPEKV NPGESAAYEAAVSYGDEAVTDADEVEFEVWKEGEKDASQMFKVKQEKGVYRLETTFKE DGVYTVQSHVTAKKQHSMPTLKVQVGDADAASNQSEEEHSHHH*" /label="ytkA CDS" gene complement(2570502..2570939) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /label="ytkA gene" downshifts 2570528 /Source="Nicolas_upshifts" /id="D1580" /incds=0 /nref=37 /ntot=155 /MaxReadThrough="2.0116" /MaxDrop="3.95427" /score="13.1411485" /energy="-20.5" /TU="NA" /idTUdmin="U2376" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2570958..2570977) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-10" upshifts complement(2570979) /Source="Nicolas_upshifts" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 complement(2570988..2570996) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-35" CDS complement(2571059..2571532) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /EC_number="4.4.1.21" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-ribosylhomocysteine lyase" /protein_id="NP_390945.1" /db_xref="EnsemblGenomes-Gn:BSU30670" /db_xref="EnsemblGenomes-Tr:CAB15045" /db_xref="GOA:O34667" /db_xref="InterPro:IPR003815" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR037005" /db_xref="PDB:1IE0" /db_xref="PDB:1J98" /db_xref="PDB:1JQW" /db_xref="PDB:1JVI" /db_xref="PDB:1YCL" /db_xref="PDB:2FQO" /db_xref="PDB:2FQT" /db_xref="SubtiList:BG13866" /db_xref="UniProtKB/Swiss-Prot:O34667" /translation="MPSVESFELDHNAVVAPYVRHCGVHKVGTDGVVNKFDIRFCQPN KQAMKPDTIHTLEHLLAFTIRSHAEKYDHFDIIDISPMGCQTGYYLVVSGEPTSAEIV DLLEDTMKEAVEITEIPAANEKQCGQAKLHDLEGAKRLMRFWLSQDKEELLKVFG*" /label="luxS CDS" gene complement(2571059..2571532) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /label="luxS gene" downshifts complement(2571068) /Source="Nicolas_upshifts" /id="D1581" /incds=0 /nref=72 /ntot=201 /MaxReadThrough="4.53626" /MaxDrop="4.63695" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-793" /isTUend="FALSE" /label="downshifts" downshifts complement(2571155) /Source="Nicolas_upshifts" /id="D1582" /incds=1 /nref=1 /ntot=96 /MaxReadThrough="5.57623" /MaxDrop="2.4806" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" S_feature complement(2571533..2571884) /Source="Nicolas_S_feature" /locus_tag="new_3137969_3138320_c" /HighExp="Etha, B36, B60, BMM, S2, Heat, S1, LoTm, Lbtran, S5" /AntisenseName="ytjA" /AntisenseCor="-0.45038987072908898" /AntisenseRegPval="-14.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1173" promotor_-35 2571604..2571611 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2571624..2571643 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2571629 /Source="Nicolas_upshifts" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2571661..2571888 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19306042, 21803992; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein insertion efficiency factor" /protein_id="NP_390946.1" /db_xref="EnsemblGenomes-Gn:BSU30680" /db_xref="EnsemblGenomes-Tr:CAB15046" /db_xref="GOA:O34601" /db_xref="InterPro:IPR002696" /db_xref="SubtiList:BG13865" /db_xref="UniProtKB/Swiss-Prot:O34601" /translation="MKTLFIALIRGYQKFISPLTPPTCRFYPTCSQYGIEAIKTHGAL KGGWLTIKRILKCHPFHPGGVDPVPEKKQKH*" /label="ytjA CDS" gene 2571661..2571888 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /label="ytjA gene" CDS complement(2571885..2572448) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /EC_number="4.2.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12193617, 21266987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carbonic anhydrase" /protein_id="NP_390947.1" /db_xref="EnsemblGenomes-Gn:BSU30690" /db_xref="EnsemblGenomes-Tr:CAB15047" /db_xref="GOA:O34872" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG13863" /db_xref="UniProtKB/Swiss-Prot:O34872" /translation="MSLLNDILEFNKTFTEQREYEKYQTSKFPDKKMAILSCMDTRLV ELLPHAMNLRNGDVKIIKSAGALVTHPFGSIMRSILVAVYELNADEVCVIGHHDCGMS KISSKSMLEKIKARGIPEERIETIKYSGVDFDQWFKSFDSVEASVKDSVDVIKHHPLF PENVPVHGLVIDPKTGKLDLIVNGYNN*" /label="ytiB CDS" gene complement(2571885..2572448) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /label="ytiB gene" misc_feature complement(2572473..2572492) /Source="Nicolas_upshift_promotors" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2572488) /Source="Nicolas_upshifts" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2572542..2572790) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15049826, 16014871, 16547061, 19648245, 20208344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15049826, 16014871, 16547061, 19648245, 20208344; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_390948.1" /db_xref="EnsemblGenomes-Gn:BSU30700" /db_xref="EnsemblGenomes-Tr:CAB15048" /db_xref="GOA:O34967" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027493" /db_xref="InterPro:IPR034704" /db_xref="SubtiList:BG13862" /db_xref="UniProtKB/Swiss-Prot:O34967" /translation="MKEGIHPKNHKVIFQDVNSGYRFLSTSTKTSNETAEWEDGNTYP VIKVEVSSDTHPFYTGRQKFNEKGGRVEQFKKRYNMGK*" /label="rpmEB CDS" gene complement(2572542..2572790) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /label="rpmEB gene" downshifts complement(2572563) /Source="Nicolas_upshifts" /id="D1583" /incds=0 /nref=96 /ntot=217 /MaxReadThrough="7.96356" /MaxDrop="4.50701" /score="15.8096104" /energy="-7.5" /TU="U2380" /idTUdmin="U2380" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2572818..2572837) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-10" promotor_-35 complement(2572851..2572858) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-35" upshifts complement(2572855) /Source="Nicolas_upshifts" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 2572917..2572923 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-35" promotor_-10 2572937..2572948 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-10" upshifts 2572949 /Source="Nicolas_upshifts" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="upshifts" CDS 2572995..2574326 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9852001, 10551842, 15849754, 16850406, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit I" /protein_id="NP_390949.2" /db_xref="EnsemblGenomes-Gn:BSU30710" /db_xref="EnsemblGenomes-Tr:CAB15049" /db_xref="GOA:C0SP90" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG13857" /db_xref="UniProtKB/Swiss-Prot:C0SP90" /translation="MDDLVLARSLFGTTMGFHIIFATLGVGLPLMILVAELIYQKTKD DHYAIMAKRWTKAQAVLLGVAIPTGTIAGTQLALLWPGFMEVIGRVMSLPFQIEIYAF FVEALFMSIYVYAADRLSPAMRIVAVFFVLVGAAASAVLITNVHAFEGTPAGFKILNG KITDVDPWAAFFNPSFFITAGHVVLSAFMTGAFIVASVAAYKMIRTRKKERVYRFHRK ALLLALTIGGIFSLLTALNGHESAQMLYEYQPEKLAGAEGLFETRSHAPLAIGGFTDP NEEKVKWAIEIPWALSFLAANRFDTVVKGLNAFPRDEWPPLFIHTLFNAMVGVGMLLI LYSIIGVVWRKVLKKDRFPTWLLIIFMTAGPFSLIGIEFGWIFACTGRQPWVIYHLLK TSDVVTTTGSIGVLFLFFTFVYAVLGAAVVYVLLYYFRKHPVDEDLNTAES*" /label="ythA CDS" gene 2572995..2574326 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /label="ythA gene" CDS 2574370..2575410 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11073895, 15576792, 15849754, 16850406, 10551842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit II" /protein_id="NP_390950.1" /db_xref="EnsemblGenomes-Gn:BSU30720" /db_xref="EnsemblGenomes-Tr:CAB15050" /db_xref="GOA:O34505" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG13858" /db_xref="UniProtKB/Swiss-Prot:O34505" /translation="MEISTDALIAISIIWGFVFIYAVMATMDFGAGFWSMIYLNKEHM KATDIANRFLSPTWEVTNVFIVAIVVALFSFFPGATFVLGTVLLIPGSMILLLLAIRS GFLVFSNTAKERKTLRYISGISGFIIPAILILVLPVTHGGFIEKTDGIYNLNMSKIFS SPNAYSFIGFAILSTLFLSSLLLADFSNVAEEQDAYRAYRKSALITGPISLLFAVCIM VTMRNEANWLYSGMMNDFSWIIASFITFVIAGIALFLPNKSFGQNIGKPRLALVAIGI QYFLASYAYGRAHLPYMIYPDVTVMSGFTEPATFRALFATYIVAFIILFPGFFFFWKM FMRDKRYIRQEE*" /label="ythB CDS" gene 2574370..2575410 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /label="ythB gene" promotor_-35 2575404..2575410 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2575425..2575436 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2575435 /Source="Nicolas_upshifts" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="upshifts" CDS 2575464..2575622 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097775.1" /db_xref="EnsemblGenomes-Gn:BSU30739" /db_xref="EnsemblGenomes-Tr:CAX52681" /db_xref="InterPro:IPR011437" /db_xref="UniProtKB/Swiss-Prot:C0H3Q2" /translation="MEQKILCEVNNCSYWGKGNKCTADAIYVVSHTGETAENSRETDC KTFKPHDL*" /label="ytzL CDS" gene 2575464..2575622 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /label="ytzL gene" downshifts 2575611 /Source="Nicolas_upshifts" /id="D1584" /incds=0 /nref=55 /ntot=88 /MaxReadThrough="1.7679" /MaxDrop="7.01398" /score="-5.86934022" /energy="-7" /TU="NA" /idTUdmin="U2382" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2575641..2576528) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390952.1" /db_xref="EnsemblGenomes-Gn:BSU30740" /db_xref="EnsemblGenomes-Tr:CAB15052" /db_xref="GOA:O34500" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG13854" /db_xref="UniProtKB/Swiss-Prot:O34500" /translation="MSFEAWIIATGVLVGVSCGLIGTFLVLRSMAMLADAISHTVLLG IVGAFLVTGSLDGIYMFIGAAATGLLTAFLVQLLHSKGVQSDAAIGVVFTSLFAIGVI LLSVYGANVHLDIEHSLMGEIAFVPWNTVTVFGVDIGPKAFWMLASVLVLNVVLISVC YKEFKIASFDPQMALALGIPVLLIHYVQMGMLSLTTVASFDSVGAVLVVAMLIVPPAA AHLLTDRLLYMLILSALIGGLSAVMGYFFATWLNVSISGAMAAMTGVCYASAFLFSPA NGVITKKLRTLNMQKERAG*" /label="mntD CDS" gene complement(2575641..2576528) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /label="mntD gene" downshifts complement(2575664) /Source="Nicolas_upshifts" /id="D1585" /incds=0 /nref=121 /ntot=218 /MaxReadThrough="3.39755" /MaxDrop="6.80546" /score="-8.37820006" /energy="-7" /TU="U2385" /idTUdmin="U2385" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" CDS complement(2576518..2577825) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390953.1" /db_xref="EnsemblGenomes-Gn:BSU30750" /db_xref="EnsemblGenomes-Tr:CAB15053" /db_xref="GOA:O35024" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13853" /db_xref="UniProtKB/Swiss-Prot:O35024" /translation="MFESLWLQLQHPNTQWVLAGTLLLGTASGVLGSFVLLRKQSLIG DAMAHSALPGVCLAFLFTGQKSLPFFLLGAALAGLLGTFCIQLIPRLSKTKEDSAIGI VLSVFFGVGIILLTYIQQQGAGSQSGLDSFLFGQAASLVRQDIILIAGISAVLLLLCI VFFKEFTLITFDLAFAKGLGIPVRFLNGLLACLIVCAVVIGLQTVGVILMAAMLITPA ITARYWTERLTGMIIIAGITGGVSGVAGTLLSTTMKGMATGPLMILSATLLFLFSMIC APKRGLAAKAIRLMRLRRRTSREQVLLAIYEQYEKNNLCVTVESVRKKRRLSPSLCLK ALNDLEQERCIERIENGIWQITSKGIEKGYHTALKQRMYEVYLMHEMELANIESDQDY FDPDRLPRETRERLYSLLKLYGRMPERRKASHDAEKGQIANEF*" /label="mntC CDS" gene complement(2576518..2577825) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /label="mntC gene" CDS complement(2577831..2578583) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type t: transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (ATP-binding protein)" /protein_id="NP_390954.1" /db_xref="EnsemblGenomes-Gn:BSU30760" /db_xref="EnsemblGenomes-Tr:CAB15054" /db_xref="GOA:O34338" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13852" /db_xref="UniProtKB/Swiss-Prot:O34338" /translation="MFPVELDNVTVAYHKKPVLQDISLQVPEGKLIGIIGPNGAGKST LIKTILGLVPRASGDISIYGKDYKDQRTRIGYVPQRGSVDWDFPTSPLDVVLMGRYGR IGLLKRPKKADVEMAKAALTKVGMHDYAKRQISQLSGGQQQRVFLARALCQNADIYFM DEPFAGVDAATERAIMTLLAELKEKGKTVLVVHHDLQTAEDYFDWILLLHLRKIAFGP TENVFTIENLQKTYGGRLTFLKDKVLAEGHKE*" /label="mntB CDS" gene complement(2577831..2578583) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /label="mntB gene" CDS complement(2578602..2579522) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (manganese binding lipoprotein)" /protein_id="NP_390955.1" /db_xref="EnsemblGenomes-Gn:BSU30770" /db_xref="EnsemblGenomes-Tr:CAB15055" /db_xref="GOA:O34385" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="SubtiList:BG13851" /db_xref="UniProtKB/Swiss-Prot:O34385" /translation="MRQGLMAAVLFATFALTGCGTDSAGKSADQQLQVTATTSQIADA AENIGGKHVKVTSLMGPGVDPHLYKASQGDTKKLMSADVVLYSGLHLEGKMEDVLQKI GEQKQSAAVAEAIPKNKLIPAGEGKTFDPHVWFSIPLWIYAVDEIEAQFSKAMPQHAD AFRKNAKEYKEDLQYLDKWSRKEIAHIPEKSRVLVTAHDAFAYFGNEYGFKVKGLQGL STDSDYGLRDVQELVDLLTEKQIKAVFVESSVSEKSINAVVEGAKEKGHTVTIGGQLY SDAMGEKGTKEGTYEGMFRHNINTITKALK*" /label="mntA CDS" gene complement(2578602..2579522) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /label="mntA gene" promotor_-10 complement(2579558..2579569) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2579559) /Source="Nicolas_upshifts" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2579561..2579652) /Source="Nicolas_S_feature" /locus_tag="new_3145997_3146088_c" /HighExp="T-0.40H, Sw, T-1.40H, BC, C90, C30, BI, T0.0H, T-3.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.985, 0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1174" promotor_-35 complement(2579583..2579589) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2579637 /Source="Nicolas_upshifts" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2579638..2579657) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2579640..2579652 /Source="Nicolas_upshift_promotors" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2579652) /Source="Nicolas_upshifts" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2579654..2579735) /Source="Nicolas_S_feature" /locus_tag="new_3146090_3146171_c" /HighExp="T1.30H, T1.0H, C30, T0.30H, T2.0H, T2.30H, T-0.40H, T-1.40H, T-2.40H, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1175" promotor_-35 complement(2579672..2579679) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2579735) /Source="Nicolas_upshifts" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="upshifts" promotor_-10 complement(2579744..2579763) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-10" promotor_-35 complement(2579777..2579784) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-35" CDS complement(2579802..2580917) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /EC_number="4.2.1.113" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoate-CoA synthase" /protein_id="NP_390956.1" /db_xref="EnsemblGenomes-Gn:BSU30780" /db_xref="EnsemblGenomes-Tr:CAB15056" /db_xref="GOA:O34514" /db_xref="InterPro:IPR010197" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG13847" /db_xref="UniProtKB/Swiss-Prot:O34514" /translation="MIEIEKITLYHLSMNLKKPFKNSIETLQERKFLIVEAIDTSGVT GWGEVSAFSSPWYTEETIGTCLHMLKDFFIPNVVGREFNHPSEVPDSLARYKGNRMAK AGLESAVWDIYAKKKGVSLAEALGGTRDKVPAGVVVGLAPLDDMLKEIESYQKEGYQR IKIKIQPGQDVELVKAIRSRFPTIPLMADANSSYELKDISRLKELDDYHLMMIEQPLQ ADDIVDHRHLQKHLKTAICLDESICSVDDARRAIELGSCKIINIKPSRVGGLTEALKI HDLCKEHHMQVWCGGMLETGISRAQNVALASLPQFTIPGDISSSSRYWDEDIVTPDIR IDNGFISVSKQPGLGVEVNQDIMRKYVTKMDVFTQHG*" /label="menC CDS" gene complement(2579802..2580917) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /label="menC gene" downshifts complement(2579845) /Source="Nicolas_upshifts" /id="D1586" /incds=0 /nref=12 /ntot=179 /MaxReadThrough="3.8638" /MaxDrop="2.96378" /score="29.7201414" /energy="-11.1" /TU="U2387,U2388" /idTUdmin="U2388" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2580914..2582374) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /EC_number="6.2.1.26" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299, 28559280" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299, 28559280; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoic acid-CoA ligase" /protein_id="NP_390957.1" /db_xref="EnsemblGenomes-Gn:BSU30790" /db_xref="EnsemblGenomes-Tr:CAB15057" /db_xref="GOA:P23971" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010192" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:5BUQ" /db_xref="PDB:5BUR" /db_xref="PDB:5BUS" /db_xref="PDB:5GTD" /db_xref="PDB:5X8F" /db_xref="PDB:5X8G" /db_xref="SubtiList:BG10687" /db_xref="UniProtKB/Swiss-Prot:P23971" /translation="MLTEQPNWLMQRAQLTPERIALIYEDQTVTFAELFAASKRMAEQ LAAHSVRKGDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSG FLLTDSSFEKKEYEHIVQTIDVDELMKEAAEEIEIEAYMQMDATATLMYTSGTTGKPK GVQQTFGNHYFSAVSSALNLGITEQDRWLIALPLFHISGLSALFKSVIYGMTVVLHQR FSVSDVLHSINRHEVTMISAVQTMLASLLEETNRCPESIRCILLGGGPAPLPLLEECR EKGFPVFQSYGMTETCSQIVTLSPEFSMEKLGSAGKPLFSCEIKIERDGQVCEPYEHG EIMVKGPNVMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGE NIYPAEVESVLLSHPAVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTDYCKERLA KYKIPAKFFVLDRLPRNASNKLLRNQLKDARKGELL*" /label="menE CDS" gene complement(2580914..2582374) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /label="menE gene" promotor_-10 complement(2581817..2581835) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2581821) /Source="Nicolas_upshifts" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2581850..2581856) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2582463) /Source="Nicolas_upshifts" /id="D1587" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="4.92536" /MaxDrop="2.4145" /score="1.01127104" /energy="-10.8" /TU="U2388" /idTUdmin="U2389" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS complement(2582465..2583280) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /EC_number="4.1.3.36" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxynapthoic acid synthetase" /protein_id="NP_390958.1" /db_xref="EnsemblGenomes-Gn:BSU30800" /db_xref="EnsemblGenomes-Tr:CAB15058" /db_xref="GOA:P23966" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR010198" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG10686" /db_xref="UniProtKB/Swiss-Prot:P23966" /translation="MAEWKTKRTYDEILYETYNGIAKITINRPEVHNAFTPKTVAEMI DAFADARDDQNVGVIVLAGAGDKAFCSGGDQKVRGHGGYVGDDQIPRLNVLDLQRLIR VIPKPVVAMVSGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARI VGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEQLEEETIKWCEEMLEKSPTALRFL KAAFNADTDGLAGIQQFAGDATLLYYTTDEAKEGRDSFKEKRKPDFGQFPRFP*" /label="menB CDS" gene complement(2582465..2583280) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /label="menB gene" CDS complement(2583315..2584139) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /EC_number="4.2.99.20" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12454479, 23637813; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase" /protein_id="NP_390959.1" /db_xref="EnsemblGenomes-Gn:BSU30810" /db_xref="EnsemblGenomes-Tr:CAB15059" /db_xref="GOA:P23974" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR022485" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10685" /db_xref="UniProtKB/Swiss-Prot:P23974" /translation="MGTVNITVSDGVRYAVADEGPNASEAVVCLHGFTGSKQSWTFLD EMLPDSRLIKIDCLGHGETDAPLNGKRYSTTRQVSDLAEIFDQLKLHKVKLIGYSMGG RLAYSFAMTYPERVSALVLESTTPGLKTLGERRERIMRDRKLADFILRDGLEAFVAYW ENIPLFSSQQRLAEDIRYRIRSGRLRNNKIGLANSLTGMGTGSQPSLWSRVEEIDVPV LLICGEWDEKFCAINQEVHKMLPSSRIEIVPKAGHTVHVEQPRLFGKIVSEFLTSI*" /label="menH CDS" gene complement(2583315..2584139) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /label="menH gene" promotor_-10 complement(2583397..2583416) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2583397) /Source="Nicolas_upshifts" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2583432..2583435) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2583563) /Source="Nicolas_upshifts" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2583573..2583584) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2583599..2583605) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2584127..2585869) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /EC_number="2.2.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate decarboxylase and 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase" /protein_id="NP_390960.1" /db_xref="EnsemblGenomes-Gn:BSU30820" /db_xref="EnsemblGenomes-Tr:CAB15060" /db_xref="GOA:P23970" /db_xref="InterPro:IPR004433" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR032264" /db_xref="PDB:2X7J" /db_xref="SubtiList:BG10683" /db_xref="UniProtKB/Swiss-Prot:P23970" /translation="MTVNPITHYIGSFIDEFALSGITDAVVCPGSRSTPLAVLCAAHP DISVHVQIDERSAGFFALGLAKAKQRPVLLICTSGTAAANFYPAVVEAHYSRVPIIVL TADRPHELREVGAPQAINQHFLFGNFVKFFTDSALPEESPQMLRYIRTLASRAAGEAQ KRPMGPVHVNVPLREPLMPDLSDEPFGRMRTGRHVSVKTGTQSVDRESLSDVAEMLAE AEKGMIVCGELHSDADKENIIALSKALQYPILADPLSNLRNGVHDKSTVIDAYDSFLK DDELKRKLRPDVVIRFGPMPVSKPVFLWLKDDPTIQQIVIDEDGGWRDPTQASAHMIH CNASVFAEEIMAGLTAATRSSEWLEKWQFVNGRFREHLQTISSEDVSFEGNLYRILQH LVPENSSLFVGNSMPIRDVDTFFEKQDRPFRIYSNRGANGIDGVVSSAMGVCEGTKAP VTLVIGDLSFYHDLNGLLAAKKLGIPLTVILVNNDGGGIFSFLPQASEKTHFEDLFGT PTGLDFKHAAALYGGTYSCPASWDEFKTAYAPQADKPGLHLIEIKTDRQSRVQLHRDM LNEAVREVKKQWEL*" /label="menD CDS" gene complement(2584127..2585869) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /label="menD gene" CDS complement(2585866..2587281) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /EC_number="5.4.4.2" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinone-specific isochorismate synthase" /protein_id="NP_390961.1" /db_xref="EnsemblGenomes-Gn:BSU30830" /db_xref="EnsemblGenomes-Tr:CAB15061" /db_xref="GOA:P23973" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR034681" /db_xref="SubtiList:BG10682" /db_xref="UniProtKB/Swiss-Prot:P23973" /translation="MVTTVQRTFRKEVLHALHKAKEVNHAVLISYSRQIESLDPLSFF NYGAKKYTGNRFFWSDPESELTIVGLGKEAVFQTNQKNSERYREVFEQWERFKKTAFH IYEEEKLQHSAVGPVLFGGFSFDPCEERGSQWDHFSEGDFFVPALMLTMTAEGPFLTV NRWVSGGEDAEAVLEGLKAFAAEFMVPDFKQEDQAVIAAAEELDKDDWLKAIETATSQ IKEKQYDKVVLARELLLTFDGPIQIEPVLKTLLDDQQTSYVFAIEQEGKTFVGASPER LIKRDGGTVMSSCLAGSIKRGVNEEDDRRIGLELLNDEKNLLEHDIVVGMIHNAFVSS CSEVEKPDGPVLYKTKSVQHLFTPIVGQLRESASIFDLIEKLHPTPALGGSPQEKAVD VIREIEPMSRGWYAAPIGWIDSQDNGEFAVAIRSGLIEGSTARLFAGCGIVEDSEPIS EYEETQIKLKPMISALGGERR*" /label="menF CDS" gene complement(2585866..2587281) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /label="menF gene" S_feature complement(2587282..2587394) /Source="Nicolas_S_feature" /locus_tag="new_3153718_3153830_c" /HighExp="dia5, LBGstat, Diami, LBGtran, dia15, H2O2, G180, G150, LPhT, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1176" promotor_-10 complement(2587374..2587393) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-10" upshifts complement(2587394) /Source="Nicolas_upshifts" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="upshifts" S_feature complement(2587396..2587546) /Source="Nicolas_S_feature" /locus_tag="new_3153832_3153982_c" /HighExp="S8, S7, S6, S5, BT, S4, Pyr, B36, G/S, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1177" promotor_-35 complement(2587409..2587412) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-35" promotor_-35 2587507..2587513 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2587527..2587546) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2587527..2587538 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2587535 /Source="Nicolas_upshifts" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2587546) /Source="Nicolas_upshifts" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2587560..2587569) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2587571..2588290 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative regulatory protein" /protein_id="NP_390962.2" /db_xref="EnsemblGenomes-Gn:BSU30840" /db_xref="EnsemblGenomes-Tr:CAB15062" /db_xref="GOA:P42408" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR014240" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG11200" /db_xref="UniProtKB/Swiss-Prot:P42408" /translation="MLTKEQLQHLKNELEQTKKDILNRFKDNDHFQLNSAFPYDSWGE LSAYDNHPGDQATELYEREKDIALDLHEREHLRDIEHSLKAIENGTYGICEVSGKEIP FERLEALPTATTLAEYSSQDVVSKDRPIEEETPFGQFEFDDDEEIRAPYDSEDSYQDV EKYGNSQTPQDMENPPLSYDDMTMNAEENIGNTESYENFIATDITGKEITVYQSRAHE RYEEELDEEGIMTTFGDLHAD*" /label="yteA CDS" gene 2587571..2588290 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /label="yteA gene" S_feature complement(2587641..2588298) /Source="Nicolas_S_feature" /locus_tag="new_3154077_3154734_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, S3" /AntisenseName="yteA" /AntisenseCor="0.85796245341056299" /AntisenseRegPval="-78.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1178" downshifts 2588279 /Source="Nicolas_upshifts" /id="D1588" /incds=0 /nref=23 /ntot=40 /MaxReadThrough="0.72949" /MaxDrop="5.85132" /score="2.75726503" /energy="-10.1" /TU="NA" /idTUdmin="U2391" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2588299..2589117) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_390963.1" /db_xref="EnsemblGenomes-Gn:BSU30850" /db_xref="EnsemblGenomes-Tr:CAB15063" /db_xref="GOA:P42407" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11199" /db_xref="UniProtKB/Swiss-Prot:P42407" /translation="MIKKAIIPAGGFGTRNLPVTKVIPKEMFPVGSKPVIHYLVEELK ESGIEDILMVVSSHKNLIVDYFDSSLALEAFLASKNKLHLLREHPIPDIRIHYVRQPY AKGLGDAISFGKQFAGGEPFAVVLPDDLIFSANQPALGQLIEAYTKYQSSVIGLKETK TEDLHHYGVIKGEPVEKGLYRIQDIVEKPKQNPPSHFAAAGRYIFTPDIFNELEALEA DSGGEVQVTDAIKASLGACTVYGKLLEGERYDIGLQKDYLKLIYDMLKTEKNPQ*" /label="ytdA CDS" gene complement(2588299..2589117) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /label="ytdA gene" promotor_-10 complement(2589138..2589157) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2589152) /Source="Nicolas_upshifts" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2589172..2589180) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2589218..2589226 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2589239..2589258 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2589240 /Source="Nicolas_upshifts" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="upshifts" CDS 2589289..2590575 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /EC_number="1.1.1.22" /function="16.14: Store" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose dehydrogenase" /protein_id="NP_390964.1" /db_xref="EnsemblGenomes-Gn:BSU30860" /db_xref="EnsemblGenomes-Tr:CAB15064" /db_xref="GOA:O34862" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13828" /db_xref="UniProtKB/Swiss-Prot:O34862" /translation="MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVI PFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIAVGTPPRSDGSADTKALQSVIGD LSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDML HPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFIN EMARICEAYQSDISDISRAIGLDPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNT ETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKPNTDDIRNSQAVRLM ERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWK KAADIMKGRLVIDGRNVLKKELIEACGLICTGVGRP*" /label="ytcA CDS" gene 2589289..2590575 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /label="ytcA gene" CDS 2590572..2591522 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose epimerase" /protein_id="NP_390965.1" /db_xref="EnsemblGenomes-Gn:BSU30870" /db_xref="EnsemblGenomes-Tr:CAB15065" /db_xref="GOA:O34886" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13829" /db_xref="UniProtKB/Swiss-Prot:O34886" /translation="MKILVTGAAGFIGSHLCEELLKDKKHNVIGIDDFIGPTPFSLKL KNLKNLLPEKRFTFIKENLLTADLASLLEGVDVIFHLAAIPGVRSSWGNHFHPYAAHN IQALQRLLEACREHSIQTFVFASTSSVYGEKQGKVSENTSLSPLSPYGVTKLTGEKLC HVYKQSFGIPIVILRFFTVYGPRQRPDMAFHRLIKQHLQQKPLTIFGDGQQSRDFTYI SDCVKGITAVLGKPHLIGETVNIGGAERASVLKVVSLIEDISGRKATLHFSDKIAGEP SNTWADISKAKQLLHYDPATSLKDGLTNEIAYLSSLYQGE*" /label="ytcB CDS" gene 2590572..2591522 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /label="ytcB gene" CDS 2591525..2592748 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /EC_number="2.4.1.-" /function="16.14: Store" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glucosyltransferase" /protein_id="NP_390966.1" /db_xref="EnsemblGenomes-Gn:BSU30880" /db_xref="EnsemblGenomes-Tr:CAB15066" /db_xref="GOA:O34413" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG13830" /db_xref="UniProtKB/Swiss-Prot:O34413" /translation="MKLAFICTEKLPAPAVRGGAIQMMIDGVTPYFSSRYDLTIFSIE DPSLPKRETKDGVHYIHLPKEHYREAVAEELRASSFDLIHVFNRPLNVSLYKKASPNS KIVLSLHNEMFSEKKMTFAQGKEVLDNVSMITTVSEFIKQTVIERFPEAEDITKVVYS GVDLNSYPPVWTMKGSAVRKTYRKKYGIEDKKVILFAGRLSPTKGPHLLIHSMRRILQ QHPDAVLVIAGGKWFSDDSENQYVTYLRTLALPYRDHIIFTKFIPADDIPNLFLMADV FVCSSQWNEPLARVNYEAMAAGTPLITTNRGGNGEVVKHEVTGLVIDSYNKPSSFAKA IDRAFTDQELMNKMTKNARKHVEALFTFTHAAKRLNTVYQSVLTPKNKQFPPPFLTQN FDLSSINQLFVKAKT*" /label="ytcC CDS" gene 2591525..2592748 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /label="ytcC gene" downshifts complement(2592672) /Source="Nicolas_upshifts" /id="D1589" /incds=1 /nref=1 /ntot=10 /MaxReadThrough="1.32025" /MaxDrop="3.47267" /score="-3.65321449" /energy="-3.1" /TU="NA" /idTUdmin="U2395" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2592749..2593316 /Source="Nicolas_S_feature" /locus_tag="new_3159185_3159752" /HighExp="S8, S7, BT, S6, C30, Pyr, S5, G/S, C90, Glucon" /AntisenseName="ytxO" /AntisenseCor="0.86121563743373297" /AntisenseRegPval="-79.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1179" CDS complement(2592822..2593253) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="outer spore coat protein" /protein_id="NP_390967.1" /db_xref="EnsemblGenomes-Gn:BSU30890" /db_xref="EnsemblGenomes-Tr:CAB15067" /db_xref="SubtiList:BG11382" /db_xref="UniProtKB/Swiss-Prot:P46916" /translation="MRSSRQKASISKLDLDQFVFTPPGPMGWQAHDSISAEKEEEEKH LDVGSIRELPHINAPKEYQKETKEKETDRKIVDDEEETKFETTLEPEEERDSKRSAPP YEEEDEDEEPDLAEEAKVEIIILPSESKPAPWFSQTVKRKA*" /label="cotOO CDS" gene complement(2592822..2593253) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /label="cotOO gene" downshifts complement(2592848) /Source="Nicolas_upshifts" /id="D1590" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="3.07378" /MaxDrop="4.8822" /score="9.30990044" /energy="-8.3" /TU="U2395" /idTUdmin="U2395" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(2593255..2594310) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7545510, 9603889, 10234840, 11737650, 14702409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7545510, 9603889, 10234840, 11737650, 14702409; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390968.1" /db_xref="EnsemblGenomes-Gn:BSU30900" /db_xref="EnsemblGenomes-Tr:CAB15068" /db_xref="GOA:P46914" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="SubtiList:BG11380" /db_xref="UniProtKB/Swiss-Prot:P46914" /translation="MYQKEHEEQIVSEILSYYPFHIDHVALKSNKSGRKIWEVETDHG PKLLKEAQMKPERMLFITQAHAHLQEKGLPIAPIHQTKNGGSCLGTDQVSYSLYDKVT GKEMIYYDAEQMKKVMSFAGHFHHASKGYVCTDESKKRSRLGKWHKLYRWKLQELEGN MQIAASYPDDVFSQTFLKHADKMLARGKEALRALDDSEYETWTKETLEHGGFCFQDFT LARLTEIEGEPFLKELHSITYDLPSRDLRILLNKVMVKLSVWDTDFMVALLAAYDAVY PLTEKQYEVLWIDLAFPHLFCAIGHKYYLKQKKTWSDEKYNWALQNMISVEESKDSFL DKLPELYKKIKAYREAN*" /label="cotS CDS" gene complement(2593255..2594310) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /label="cotS gene" CDS complement(2594325..2595458) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9603889, 10234840, 11737650" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9603889, 10234840, 11737650; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390969.1" /db_xref="EnsemblGenomes-Gn:BSU30910" /db_xref="EnsemblGenomes-Tr:CAB15069" /db_xref="GOA:P46915" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11381" /db_xref="UniProtKB/Swiss-Prot:P46915" /translation="MKIALIATEKLPVPSVRGGAIQIYLEAVAPLIAKKHEVTVFSIK DPNLADREKVDGVHYVHLDEDRYEEAVGAELKKSRFDLVHVCNRPSWVPKLKKQAPDA VFILSVHNEMFAYDKISQAEGEICIDSVAQIVTVSDYIGQTITSRFPSARSKTKTVYS GVDLKTYHPRWTNEGQRAREEMRSELGLHGKKIVLFVGRLSKVKGPHILLQALPDIIE EHPDVMMVFIGSKWFGDNELNNYVKHLHTLGAMQKDHVTFIQFVKPKDIPRLYTMSDV FVCSSQWQEPLARVHYEAMAAGLPIITSNRGGNPEVIEEGKNGYIIHDFENPKQYAER INDLLSSSEKRERLGKYSRREAESNFGWQRVAENLLSVYEKNR*" /label="cotSA CDS" gene complement(2594325..2595458) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /label="cotSA gene" promotor_-10 complement(2595491..2595510) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2595510) /Source="Nicolas_upshifts" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2595523..2595532) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2595596..2595605 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2595619..2595638 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2595621 /Source="Nicolas_upshifts" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="upshifts" CDS 2595648..2596721 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816, 20077512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 20077512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat kinase" /protein_id="NP_390970.1" /db_xref="EnsemblGenomes-Gn:BSU30920" /db_xref="EnsemblGenomes-Tr:CAB15070" /db_xref="GOA:O34656" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="PDB:2Q83" /db_xref="SubtiList:BG13821" /db_xref="UniProtKB/Swiss-Prot:O34656" /translation="MCPLMAENHEVIEEGNSSELPLSAEDAKKLTELAENVLQGWDVQ AEKIDVIQGNQMALVWKVHTDSGAVCLKRIHRPEKKALFSIFAQDYLAKKGMNVPGIL PNKKGSLYSKHGSFLFVVYDWIEGRPFELTVKQDLEFIMKGLADFHTASVGYQPPNGV PIFTKLGRWPNHYTKRCKQMETWKLMAEAEKEDPFSQLYLQEIDGFIEDGLRIKDRLL QSTYVPWTEQLKKSPNLCHQDYGTGNTLLGENEQIWVIDLDTVSFDLPIRDLRKMIIP LLDTTGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLFPYELYDVIREKYVRKSAL PKEELESAFEYERIKANALRQLI*" /label="cotI CDS" gene 2595648..2596721 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /label="cotI gene" promotor_-35 2595945..2595951 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2595962 /Source="Nicolas_upshifts" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2595965..2595976 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2596710 /Source="Nicolas_upshifts" /id="D1591" /incds=0 /nref=16 /ntot=35 /MaxReadThrough="3.14769" /MaxDrop="5.1897" /score="-2.47616606" /energy="-10.3" /TU="U2396,U2397" /idTUdmin="U2396" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2596748..2596754 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2596769 /Source="Nicolas_upshifts" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2596770..2596788 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2596801..2597268 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717291, 15849754, 16850406; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative receptor" /protein_id="NP_390971.1" /db_xref="EnsemblGenomes-Gn:BSU30930" /db_xref="EnsemblGenomes-Tr:CAB15071" /db_xref="GOA:O34694" /db_xref="InterPro:IPR004307" /db_xref="SubtiList:BG13822" /db_xref="UniProtKB/Swiss-Prot:O34694" /translation="MKKIVGALAVFVITYALFSAAGYLFPVDQEWYNSLKKPDWTPSG TAIGIIWAILFALISLSAAIVYAAFSFKGAKSFWFTLLINYVLNQAFSYFQFTQKNLL AASLDCLLVAITAIVLLIIAKKYSRAASYLLLPYFLWSAFATFLSFTINSMNL*" /label="ytaB CDS" gene 2596801..2597268 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /label="ytaB gene" downshifts 2597240 /Source="Nicolas_upshifts" /id="D1592" /incds=0 /nref=43 /ntot=123 /MaxReadThrough="2.47485" /MaxDrop="5.7907" /score="9.10214462" /energy="-10.1" /TU="NA" /idTUdmin="U2396" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2597299..2599695) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /EC_number="2.4.1.1" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8145641, 9244254, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen phosphorylase" /protein_id="NP_390972.1" /db_xref="EnsemblGenomes-Gn:BSU30940" /db_xref="EnsemblGenomes-Tr:CAB15072" /db_xref="GOA:P39123" /db_xref="InterPro:IPR000811" /db_xref="InterPro:IPR011833" /db_xref="InterPro:IPR035090" /db_xref="SubtiList:BG10911" /db_xref="UniProtKB/Swiss-Prot:P39123" /translation="MFSSKERFADLFLKRLEMTCGKSFKDSAKLDQYKTLGNMVREYI SADWIETNEKSRSNSGKQTYYLSIEFLLGQLLEQNLMNLGVRDVVEAGLKEIGINLEE ILQIENDAGLGNGGLGRLAACFLDSLASLNLPGHGMGIRYKHGLFEQKIVDGHQVELP EQWLKNGNVWEVRNADQAVDVPFWGEVHMTEKSGRLHFRHEQATIVTAVPYDIPIIGY ETGTVNTLRLWNAEPYAHYHGGNILSYKRETEAVSEFLYPDDTHDEGKILRLKQQYFL VCASLKSIVNNYRKTHKSLSGLHKKVSIHINDTHPALAVPELMRILLDEENMSWEEAW HITVHTISYTNHTTLSEALEKWPIHLFKPLLPRMYMIIEEINERFCRAVWEKYPGDWK RIENMAITAHGVVKMAHLAIVGSYSVNGVAKIHSDILKEREMRDFHLLFPNRFNNKTN GIAHRRWLLKANPGLSAIITEAIGDEWVKQPESLIRLEPYATDPAFIEQFQNNKSKKK QELADLIFCTAGVVVNPESIFDVQVKRLHAYKRQLLNVLHIMYLYNRLKEDSGFSIYP QTFIFGAKASPSYYYAKKIIKLIHSVAEKVNYDPAVKQLIKVVFLENYRVSMAERIFP ASDVSEQISTASKEASGTGNMKFMMNGALTIGTHDGANIEILERVGPDCIYTFGLKAD EVLSYQENGGYRSREYYQHDRRIRQVADQLINGFFEGEADEFESIFDSLLPHNDEYFV LKDFSSYADAQERIQADYRERRKWSEHSIVNIAHSGYFSSDRTIREYAKDIWGIKPMM *" /label="glgP CDS" gene complement(2597299..2599695) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /label="glgP gene" downshifts complement(2597314) /Source="Nicolas_upshifts" /id="D1593" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="2.31076" /MaxDrop="4.39135" /score="34.694666" /energy="-10.1" /TU="NA" /idTUdmin="U2399" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2599682..2601136) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /EC_number="2.4.1.21" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:8145641, 15272305" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8145641, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen (starch) synthase" /protein_id="NP_390973.1" /db_xref="EnsemblGenomes-Gn:BSU30950" /db_xref="EnsemblGenomes-Tr:CAB15073" /db_xref="GOA:P39125" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR011835" /db_xref="InterPro:IPR013534" /db_xref="SubtiList:BG10910" /db_xref="UniProtKB/Swiss-Prot:P39125" /translation="MKILFAVSECTPFVKSGGLADVAGALPKALARLGNEVAVMLPKY SQIPEPWKKRMKKQAECTVAVGWRQQYCGIEHMAENDVNYYFIDNEYYFNRDSLYGHY DDGERFAFFSRAVLEAAKVVNVQADIVHTHDWHTAMVNYLLKEEYRKHPFYERMKSVL TIHNLQFQGIFPPDVTHDLLGLEMDHFHYERLECNGFVNFMKAGIIAADHVTTVSPTY RNEIMTPYYGEQLEQVLQYREDDVTGILNGIDDTFYQPKSDPYIEAQYDSGDLACKLE NKTKLQQRMGLPEKNDIPLISMVTRLTKQKGLDLVRRIMHELLEEQDIQLVVLGTGER EFEDYFRYAEFAFHEKCRAYIGFDEPLAHQIYAGSDMFLMPSKFEPCGLGQLIALQYG AIPIVRETGGLYDTVRAYQEEEGTGNGFTFSAFNAHDLKFTIERALSFYCQQDVWKSI VKTAMNADYSWGKSAKEYQRIFEQVTRSGRDVLE*" /label="glgA CDS" gene complement(2599682..2601136) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /label="glgA gene" CDS complement(2601133..2602164) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) beta subunit" /protein_id="NP_390974.1" /db_xref="EnsemblGenomes-Gn:BSU30960" /db_xref="EnsemblGenomes-Tr:CAB15074" /db_xref="GOA:P39124" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011832" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10909" /db_xref="UniProtKB/Swiss-Prot:P39124" /translation="MFNNQMLGVIDETTYKHSLQDLTAQRSLGAIPFAGRYRLIDFML SNMVNADIRSVAIFPKYRYRSLMDHLGAGKEWDLHRKKDGLFFFPSPHLHHEYDEFGS FRQFSDHLDYFHRSTQQYAVISNSHTVCNIQFQYVLKRHQEVGCDVTEVFQDGQSLQI YIMSTTLLKDLIYGHSEKGYKTIQEAVEKESSALTICPYEYSGYAAVIDSVEKYYTHS MELIQPRFWQQVFLPQQPIYTKVKDEPPTKYGKHSTVKNSLVANGCVLEGEVENCILF RAVHVGKGTKLKNCIIMQKTQIGEDCLLEQVISDKDVKIGKATEAAGTAEQPLVLRKG LVQGELMNS*" /label="glgD CDS" gene complement(2601133..2602164) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /label="glgD gene" CDS complement(2602188..2603330) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) subunit alpha" /protein_id="NP_390975.1" /db_xref="EnsemblGenomes-Gn:BSU30970" /db_xref="EnsemblGenomes-Tr:CAB15075" /db_xref="GOA:P39122" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005836" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011831" /db_xref="InterPro:IPR023049" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10908" /db_xref="UniProtKB/Swiss-Prot:P39122" /translation="MKKQCVAMLLAGGKGSRLSGLTKNMAKPAVSFGGKYRIIDFTLS NCSNSGIDTVGILTQYQPLELNSYIGIGSAWDLDRYNGGVTVLPPYAESSEVKWYKGT ASSIYENLNYLNQYDPEYVLILSGDHIYKMDYGKMLDYHIEKKADVTISVIEVGWEEA SRFGIMKANPDGTITHFDEKPKFPKSNLASMGIYIFNWPLLKQYLEMDDQNPYSSHDF GKDIIPLLLEEKKKLSAYPFKGYWKDVGTVQSLWEANMDLLKEDSELKLFERKWKIYS VNPNQPPQFISSDAQVQDSLVNEGCVVYGNVSHSVLFQGVTVGKHTTVTSSVIMPDVT IGEHVVIENAIVPNGMVLPDGAVIRSEKDIEEVLLVSEEFVEKELI*" /label="glgC CDS" gene complement(2602188..2603330) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /label="glgC gene" CDS complement(2603327..2605210) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /EC_number="2.4.1.18" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1296817, 15272305, 8145641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-alpha-glucan branching enzyme" /protein_id="NP_390976.1" /db_xref="EnsemblGenomes-Gn:BSU30980" /db_xref="EnsemblGenomes-Tr:CAB15076" /db_xref="GOA:P39118" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR006048" /db_xref="InterPro:IPR006407" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG10907" /db_xref="UniProtKB/Swiss-Prot:P39118" /translation="MAAASPTAHDVYLFHEGSLFKSYQLFGSHYRELNGKSGYEFCVW APHASEVRVAGDFNSWSGEEHVMHRVNDNGIWTLFIPGIGEKERYKYEIVTNNGEIRL KADPYAIYSEVRPNTASLTYDLEGYSWQDQKWQKKQKAKTLYEKPVFIYELHLGSWKK HSDGRHYSYKELSQTLIPYIKKHGFTHIELLPVYEHPYDRSWGYQGTGYYSPTSRFGP PHDLMKFVDECHQQNIGVILDWVPGHFCKDAHGLYMFDGEPLYEYKEERDRENWLWGT ANFDLGKPEVHSFLISNALYWAEFYHIDGFRVDAVANILYWPNQDERHTNPYAVDFLK KLNQTMREAYPHVMMIAEDSTEWPQVTGAVEEGGLGFHYKWNMGWMNDVLKYMETPPE ERRHCHQLISFSLLYAFSEHFVLPFSHDEVVYGKKSLLNKMPGDYWQKFAQYRLLLGY MTVHPGKKLIFMGSEFAQFDEWKDTEQLDWFLDSFPMHQKASVFTQDLLRFYQKSKIL YEHDHRAQSFEWIDVHNDEQSIFSFIRYGQKHGEALVIICNFTPVVYHQYDVGVPFFT QYIEVLNSDSETYGGSGQINKKPLSAKKGALHHKPCYITMTIPPYGISILRAVKKRGE IKR*" /label="glgB CDS" gene complement(2603327..2605210) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /label="glgB gene" S_feature 2604036..2605455 /Source="Nicolas_S_feature" /locus_tag="new_3170472_3171891" /HighExp="S8, S7, S6, C30, BT, Pyr, G/S, S2, C90, BC" /AntisenseName="glgB" /AntisenseCor="0.59299722159013002" /AntisenseRegPval="-26.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1180" promotor_-10 complement(2605242..2605257) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2605255) /Source="Nicolas_upshifts" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2605272..2605277) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2605322) /Source="Nicolas_upshifts" /id="D1594" /incds=0 /nref=2 /ntot=46 /MaxReadThrough="1.66182" /MaxDrop="3.12741" /score="36.0363304" /energy="-9.2" /TU="NA" /idTUdmin="U2401" /TUdmin=198 /isTUend="FALSE" /label="downshifts" tRNA complement(2605443..2605514) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Glu tRNA" gene complement(2605443..2605514) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /label="trnB-Glu gene" tRNA complement(2605540..2605630) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser2 tRNA" gene complement(2605540..2605630) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /label="trnB-Ser2 gene" tRNA complement(2605634..2605708) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asn tRNA" gene complement(2605634..2605708) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /label="trnB-Asn gene" tRNA complement(2605719..2605795) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ile2 tRNA" gene complement(2605719..2605795) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /label="trnB-Ile2 gene" tRNA complement(2605811..2605884) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly2 tRNA" gene complement(2605811..2605884) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /label="trnB-Gly2 gene" tRNA complement(2605895..2605970) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-His tRNA" gene complement(2605895..2605970) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /label="trnB-His gene" tRNA complement(2605988..2606063) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Phe tRNA" gene complement(2605988..2606063) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /label="trnB-Phe gene" tRNA complement(2606076..2606152) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asp tRNA" gene complement(2606076..2606152) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /label="trnB-Asp gene" tRNA complement(2606164..2606240) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met2 tRNA" gene complement(2606164..2606240) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /label="trnB-Met2 gene" tRNA complement(2606258..2606350) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser1 tRNA" gene complement(2606258..2606350) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /label="trnB-Ser1 gene" tRNA complement(2606357..2606433) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met3 tRNA" gene complement(2606357..2606433) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /label="trnB-Met3 gene" tRNA complement(2606436..2606512) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met1 tRNA" gene complement(2606436..2606512) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /label="trnB-Met1 gene" tRNA complement(2606532..2606604) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ala tRNA" gene complement(2606532..2606604) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /label="trnB-Ala gene" tRNA complement(2606610..2606686) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Pro tRNA" gene complement(2606610..2606686) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /label="trnB-Pro gene" tRNA complement(2606702..2606778) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Arg tRNA" gene complement(2606702..2606778) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /label="trnB-Arg gene" tRNA complement(2606788..2606873) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu2 tRNA" gene complement(2606788..2606873) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /label="trnB-Leu2 gene" tRNA complement(2606888..2606962) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly1 tRNA" gene complement(2606888..2606962) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /label="trnB-Gly1 gene" tRNA complement(2606968..2607054) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu1 tRNA" gene complement(2606968..2607054) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /label="trnB-Leu1 gene" tRNA complement(2607065..2607140) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Lys tRNA" gene complement(2607065..2607140) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /label="trnB-Lys gene" tRNA complement(2607178..2607253) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Thr tRNA" gene complement(2607178..2607253) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /label="trnB-Thr gene" tRNA complement(2607286..2607361) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Val tRNA" gene complement(2607286..2607361) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /label="trnB-Val gene" rRNA complement(2607382..2607499) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-5S rRNA" gene complement(2607382..2607499) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /label="rrnB-5S gene" rRNA complement(2607555..2610482) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-23S rRNA" gene complement(2607555..2610482) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /label="rrnB-23S gene" rRNA complement(2610650..2612204) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-16S rRNA" gene complement(2610650..2612204) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /label="rrnB-16S gene" Polymorphism join(2612006,2612008) /Source="geneious" /ID="SNP_BsDelta6_3178443_3178443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="T -> C" /Codon_Change /Coverage=95 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="3.5e-102" /Variant_Raw_Frequency=94 /comment="rrnB-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" S_feature complement(2612205..2612496) /Source="Nicolas_S_feature" /locus_tag="new_3178641_3178932_c" /HighExp="Diami, LPhT, C30, LBGstat, HPh, GM 120, Oxctl, Paraq, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40784100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1181" misc_feature 2612332..2612340 /Source="Nicolas_upshift_promotors" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2612338 /Source="Nicolas_upshifts" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2612448 /Source="Nicolas_upshifts" /id="D1595" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="2.91899" /MaxDrop="4.63941" /score="-0.368124787" /energy="-10.2" /TU="U2400" /idTUdmin="U2400" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2612469..2612488) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2612496) /Source="Nicolas_upshifts" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2612498..2613464) /Source="Nicolas_S_feature" /locus_tag="new_3178934_3179900_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T0.0H, T3.0H, T-0.40H, S8, T3.30H" /AntisenseName="thiT" /AntisenseCor="-0.219467435413819" /AntisenseRegPval="-3.5" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1182" promotor_-35 complement(2612502..2612509) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2612621..2612624 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2612636 /Source="Nicolas_upshifts" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2612639..2612658 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2612669..2612770 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswC RNA" gene 2612669..2612770 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /label="tswC gene" downshifts 2612769 /Source="Nicolas_upshifts" /id="D1596" /incds=0 /nref=47 /ntot=135 /MaxReadThrough="5.85975" /MaxDrop="7.03111" /score="-0.368124787" /energy="-10.2" /TU="U2402" /idTUdmin="U2400" /TUdmin=299 /isTUend="FALSE" /label="downshifts" CDS 2612870..2613448 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 19181806" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 19181806; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamin permease" /protein_id="NP_390977.1" /db_xref="EnsemblGenomes-Gn:BSU30990" /db_xref="EnsemblGenomes-Tr:CAB15077" /db_xref="GOA:O32074" /db_xref="InterPro:IPR012651" /db_xref="SubtiList:BG13949" /db_xref="UniProtKB/Swiss-Prot:O32074" /translation="MNQSKQLVRLIEIAIMTAAAVILDIVSGMFLSMPQGGSVSIMMI PIFLISFRWGVKAGLTTGLLTGLVQIAIGNLFAQHPVQLLLDYIVAFAAIGISGCFAS SVRKAAVSKTKGKLIVSVVSAVFIGSLLRYAAHVISGAVFFGSFAPKGTPVWIYSLTY NATYMVPSFIICAIVLCLLFMTAPRLLKSDKA*" /label="thiT CDS" gene 2612870..2613448 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /label="thiT gene" downshifts 2613438 /Source="Nicolas_upshifts" /id="D1597" /incds=0 /nref=129 /ntot=206 /MaxReadThrough="1.91553" /MaxDrop="5.49387" /score="35.5376279" /energy="-19.5" /TU="NA" /idTUdmin="U2402" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2613490..2614011) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390978.1" /db_xref="EnsemblGenomes-Gn:BSU31000" /db_xref="EnsemblGenomes-Tr:CAB15078" /db_xref="GOA:O32075" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13948" /db_xref="UniProtKB/Swiss-Prot:O32075" /translation="MVTVREAKLEDIKDIAKVHVDSWRTTYHEIIPIDYLNSLNYKEF EDKWKSRSLKGVFVAQDEKGSVFGFASFGPIRSEQEGYDGELYAIYLLEERQRQGAGR ALLAKGAEFLLQHGFSSMFVWVIEQNPSIIFYQAYSPERVAEDNFEIAGVRLKEVGLG WPDLSALKTLLNR*" /label="yuaI CDS" gene complement(2613490..2614011) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /label="yuaI gene" downshifts complement(2613508) /Source="Nicolas_upshifts" /id="D1598" /incds=0 /nref=8 /ntot=143 /MaxReadThrough="6.18352" /MaxDrop="5.43101" /score="13.1646679" /energy="-19.6" /TU="U2403" /idTUdmin="U2405" /TUdmin=6 /isTUend="TRUE" /label="downshifts" downshifts complement(2613580) /Source="Nicolas_upshifts" /id="D1599" /incds=1 /nref=8 /ntot=208 /MaxReadThrough="8.2849" /MaxDrop="3.3545" /score="13.1646679" /energy="-19.6" /TU="U2403,U2405" /idTUdmin="U2405" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2614029..2615558) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /experiment="publication(s) with functional evidences, PMID:9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845; Product type s: structure" /codon_start=1 /transl_table=11 /product="flotillin lipid rafts scaffold protein" /protein_id="NP_390979.1" /db_xref="EnsemblGenomes-Gn:BSU31010" /db_xref="EnsemblGenomes-Tr:CAB15079" /db_xref="GOA:O32076" /db_xref="InterPro:IPR001107" /db_xref="InterPro:IPR027705" /db_xref="InterPro:IPR031905" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG13947" /db_xref="UniProtKB/Swiss-Prot:O32076" /translation="MTMPIIMIIGVVFFLLIALIAVFITKYRTAGPDEALIVTGSYLG NKNVHVDEGGNRIKIVRGGGTFVLPVFQQAEPLSLLSSKLDVSTPEVYTEQGVPVMAD GTAIIKIGGSIGEIATAAEQFLGKSKDDREQEAREVLEGHLRSILGSMTVEEIYKNRE KFSQEVQRVASQDLAKMGLVIVSFTIKDVRDKNGYLESLGKPRIAQVKRDADIATAEA DKETRIKRAEADKDAKKSELERATEIAEAEKINQLKMAEFRREQDTAKANADQAYDLE TARARQQVTEQEMQVKIIERQKQIELEEKEILRRERQYDSEVKKKADADRYSVEQSAA AEKAKQLAEADAKKYSIEAMAKAEAEKVRIDGLAKAEAEKAKGETEAEVIRLKGLAEA EAKEKIAAAFEQYGQAAIFDMIVKMLPEYAKQAAAPLSNIDKITVVDTGGSGESSGAN KVTSYATNLMSSLQESLKASSGIDVKEMLENFSGKGNVKQSINELTNEIKEAKTIQKS E*" /label="floT CDS" gene complement(2614029..2615558) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /label="floT gene" CDS complement(2615579..2616103) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12533473, 15849754, 16850406, 18696230, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane integrity integral membrane protein" /protein_id="NP_390980.1" /db_xref="EnsemblGenomes-Gn:BSU31020" /db_xref="EnsemblGenomes-Tr:CAB15080" /db_xref="GOA:O32077" /db_xref="PDB:2K14" /db_xref="SubtiList:BG13946" /db_xref="UniProtKB/Swiss-Prot:O32077" /translation="MELFGVPIQTMYLYTLIIAGSLTLLFLFFGDVFSGLSEGIPFLN PTLVLSFFTCFSAGGYIGELVLPLSSLLIALLSCILSIMLVVLLHIFVLVPLSSAEES LAYREDDLRGRLGKVITAVPVDGFGEVVIEGIGGTISKSAVSFDNQQISYGTTVLVVD INNGVLSVTPHEPI*" /label="nfeDB CDS" gene complement(2615579..2616103) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /label="nfeDB gene" promotor_-10 complement(2616147..2616162) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-10" upshifts complement(2616153) /Source="Nicolas_upshifts" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="upshifts" S_feature complement(2616155..2616242) /Source="Nicolas_S_feature" /locus_tag="new_3182591_3182678_c" /HighExp="S4, S8, S6, S7, S5, S3, B36, LoTm, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S1183" promotor_-35 complement(2616174..2616183) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-35" promotor_-10 complement(2616227..2616245) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2616237 /Source="Nicolas_upshifts" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2616241..2616260 /Source="Nicolas_upshift_promotors" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2616242) /Source="Nicolas_upshifts" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2616260..2616265) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2616271..2616759 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390981.1" /db_xref="EnsemblGenomes-Gn:BSU31030" /db_xref="EnsemblGenomes-Tr:CAB15081" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG13945" /db_xref="UniProtKB/Swiss-Prot:O32078" /translation="MSIFNEARLETWNELKGLSDEKLNQKPSAEEWSIREVLDHLKKI DMTAQKMLKERVKDAPIKEIEEKPLEVAQDRNNKRKAPSHLEPAHDFISGSQMKRELD VVREQLTAAIASLKEEDFERVLPHPVFQELTVRQWIDFIGHHEKRHLSQMKEIKEKIE RA*" /label="yuaE CDS" gene 2616271..2616759 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /label="yuaE gene" downshifts 2616736 /Source="Nicolas_upshifts" /id="D1600" /incds=0 /nref=205 /ntot=267 /MaxReadThrough="4.05856" /MaxDrop="6.05192" /score="-4.20632485" /energy="-15" /TU="U2404" /idTUdmin="U2404" /TUdmin="-354" /isTUend="FALSE" /label="downshifts" CDS complement(2616765..2617343) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11886751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390982.1" /db_xref="EnsemblGenomes-Gn:BSU31040" /db_xref="EnsemblGenomes-Tr:CAB15082" /db_xref="GOA:O32079" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="PDB:1ORU" /db_xref="SubtiList:BG13944" /db_xref="UniProtKB/Swiss-Prot:O32079" /translation="MWKRMTAKAEGLYIADTKSFVTKQMDKLDFDYGGIPGDLHFGLT KKAGAREPMFSRGTEIFNRRQISIVSIEECNEIALKMGVPRILPEWLGANVAVSGMPD LTSLKEGSRIIFPSGAALLCEGENDPCIQPGEVIQSYYPDQPKLASAFVRHALGIRGI VCIVERPGAVYTGDEIEVHSYQRKVKRKAERV*" /label="yuaD CDS" gene complement(2616765..2617343) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /label="yuaD gene" S_feature 2616781..2617172 /Source="Nicolas_S_feature" /locus_tag="new_3183217_3183608" /HighExp="Etha, S8, LPhT, S6, Salt, LoTm, S5, H2O2, S7, dia5" /AntisenseName="yuaD" /AntisenseCor="-0.48344313728748101" /AntisenseRegPval="-16.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S1184" downshifts complement(2616792) /Source="Nicolas_upshifts" /id="D1601" /incds=0 /nref=87 /ntot=222 /MaxReadThrough="0.58189" /MaxDrop="3.9885" /score="0.718873117" /energy="-11.5" /TU="NA" /idTUdmin="U2406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2617377..2617396) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2617386) /Source="Nicolas_upshifts" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2617410..2617417) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2617431..2618639) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /EC_number="1.1.99.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="choline dehydrogenase" /protein_id="NP_390983.2" /db_xref="EnsemblGenomes-Gn:BSU31050" /db_xref="EnsemblGenomes-Tr:CAB15083" /db_xref="GOA:P71017" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG11941" /db_xref="UniProtKB/Swiss-Prot:P71017" /translation="MTLNMKVESMQKFHTFEIPTVIKHGIGAIKHTGEEVAALGVSKA LLVTDPGIYKAGVADPVIESLKEAGIEVVLFNKVEPNPPVRLVNEGSELYKKENCNGL VAVGGGSSMDTAKAIGVEATHEGSVLDYEAADGKKPLENRIPPLTTIPTTAGTGSEVT QWAVITDEEREFKFNTGGPLIAAHLTIIDPELHVSMPPHVTAMTGIDALAHAIECYTM KFAQPITDAVALMAIEYAAHYIKRAFADGEDLEARYGMAQAAMLAGLSYGSESAGAAH AMSQTLGGIIPVAHGQCVAAMMGPVMEYNWKGYPEKFARIAKAFGIDTSKMTTEEAAK ASVNWMYDLVEDLEVPTLEEQGVSPDMIERLSKEAMKDPQTFGNPRDLNEKAYNWIYK RCFNLTPKTV*" /label="gbsB CDS" gene complement(2617431..2618639) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /label="gbsB gene" downshifts complement(2617452) /Source="Nicolas_upshifts" /id="D1602" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="2.9443" /MaxDrop="3.26923" /score="18.315772" /energy="-13.6" /TU="NA" /idTUdmin="U2406" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2618408..2618427) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2618420) /Source="Nicolas_upshifts" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2618442..2618449) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2618656..2620128) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /EC_number="1.2.1.8" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 9297465, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 9297465, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine betaine aldehyde dehydrogenase, NAD+-dependent" /protein_id="NP_390984.1" /db_xref="EnsemblGenomes-Gn:BSU31060" /db_xref="EnsemblGenomes-Tr:CAB15084" /db_xref="GOA:P71016" /db_xref="InterPro:IPR011264" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11940" /db_xref="UniProtKB/Swiss-Prot:P71016" /translation="MSQTLFIDGEWISAEKEQIRSIINPFNQEEIATVSEGGREDAIK AIAAARRAFDKGEWSSLSGLERGKIVLKIAELIRRDLEELAELESLDTGKTLEESKAD MDDIANVFQYYAGLADKDGGEIISSPIPDSESKIIREPIGVCGQITPWNYPLLQASWK IAPALAAGNTIVMKPSEITPLTTIKVFKLMEEAGVPKGVANLVLGPGATVGDELAVNK DVDLISFTGGIETGKKIMRAASGNVKKIALELGGKNPNIVFKDADLEVAVDQALNAVF FHAGQVCSAGSRLLVEDAIHDQFLAELVKRAKRIKLGNGFHAETESGPLISAEHRAKV EKYVEIGIEEGAKLETGGKRPEDPELQNGFFYEPTIFSNCNSDMRIVQEEVFGPVLTV ETFSSEEEVIELANDTIYGLAGAVWSKDIEKCERVAARLRMGTVWINDFHPYFAQAPW GGYKQSGFGRELGKIGLEEYTEVKHVYRNTKPAAVNWFNS*" /label="gbsA CDS" gene complement(2618656..2620128) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /label="gbsA gene" promotor_-10 complement(2620179..2620198) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2620180) /Source="Nicolas_upshifts" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2620213..2620220) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2620240..2620246 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2620260..2620279 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2620275 /Source="Nicolas_upshifts" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2620327..2620869 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor for gbsAB" /protein_id="NP_390985.1" /db_xref="EnsemblGenomes-Gn:BSU31070" /db_xref="EnsemblGenomes-Tr:CAB15085" /db_xref="GOA:P71015" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12342" /db_xref="UniProtKB/Swiss-Prot:P71015" /translation="MDENPEFAAIEQARDLVIDSIAETMDLYGITRSVGILYGTMYMR DEMTLDEMREELQMSKPSMSTGVKKLQDLNVVKKTFHRGIRKHTFVAEKDFFKFFTNF FPPKWEREVQVNVTAIEEAQADLQKVLCKEDLDEDIKNEALQLYDQLESSKAYYDWLK RLAESVQTGEIFKFIPVETK*" /label="gbsR CDS" gene 2620327..2620869 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /label="gbsR gene" downshifts 2620852 /Source="Nicolas_upshifts" /id="D1603" /incds=0 /nref=74 /ntot=220 /MaxReadThrough="1.70461" /MaxDrop="3.5918" /score="26.1509691" /energy="-9.9" /TU="NA" /idTUdmin="U2409" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2620946..2620953 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2620966..2621066 /Source="Nicolas_S_feature" /locus_tag="new_3187402_3187502" /HighExp="BT, S0, BI, T-1.10H, T-1.40H, T1.0H, T-0.40H, T0.0H, S2, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1185" upshifts 2620966 /Source="Nicolas_upshifts" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2620968..2620987 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2621067..2621612 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /function="15.3: Cell adhesion" /experiment="publication(s) with functional evidences, PMID:21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732; Product type s: structure" /codon_start=1 /transl_table=11 /product="biofilm hydrophobic layer component" /protein_id="NP_390986.1" /db_xref="EnsemblGenomes-Gn:BSU31080" /db_xref="EnsemblGenomes-Tr:CAB15086" /db_xref="GOA:P71014" /db_xref="InterPro:IPR034650" /db_xref="PDB:4BHU" /db_xref="SubtiList:BG12341" /db_xref="UniProtKB/Swiss-Prot:P71014" /translation="MKRKLLSSLAISALSLGLLVSAPTASFAAESTSTKAHTESTMRT QSTASLFATITGASKTEWSFSDIELTYRPNTLLSLGVMEFTLPSGFTANTKDTLNGNA LRTTQILNNGKTVRVPLALDLLGAGEFKLKLNNKTLPAAGTYTFRAENKSLSIGNKFY AEASIDVAKRSTPPTQPCGCN*" /label="bslA CDS" gene 2621067..2621612 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /label="bslA gene" downshifts 2621599 /Source="Nicolas_upshifts" /id="D1604" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="0.85027" /MaxDrop="6.00835" /score="20.8976757" /energy="-10.2" /TU="NA" /idTUdmin="U2410" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2621704..2621711 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2621725..2621744 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2621732 /Source="Nicolas_upshifts" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2621737..2621905 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /product="cyclic-di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751; Product type n: RNA" /label="swdA RNA" gene 2621737..2621905 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /label="swdA gene" downshifts 2621886 /Source="Nicolas_upshifts" /id="D1605" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="6.04086" /MaxDrop="4.75274" /score="3.29445061" /energy="-6.1" /TU="U2411" /idTUdmin="U2410" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 2621978..2622646 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 23598340, 23671116, 25957408, 26771197" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 23598340, 23671116, 25957408, 26771197; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_390987.1" /db_xref="EnsemblGenomes-Gn:BSU31090" /db_xref="EnsemblGenomes-Tr:CAB15087" /db_xref="GOA:O32080" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="PDB:1LSU" /db_xref="PDB:2HMS" /db_xref="PDB:2HMT" /db_xref="PDB:2HMU" /db_xref="PDB:2HMV" /db_xref="PDB:2HMW" /db_xref="PDB:4J7C" /db_xref="PDB:4J90" /db_xref="PDB:4J91" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13943" /db_xref="UniProtKB/Swiss-Prot:O32080" /translation="MGRIKNKQFAVIGLGRFGGSICKELHRMGHEVLAVDINEEKVNA YASYATHAVIANATEENELLSLGIRNFEYVIVAIGANIQASTLTTLLLKELDIPNIWV KAQNYYHHKVLEKIGADRIIHPEKDMGVKIAQSLSDENVLNYIDLSDEYSIVELLATR KLDSKSIIDLNVRAKYGCTILAIKHHGDICLSPAPEDIIREQDCLVIMGHKKDIKRFE NEGM*" /label="ktrA CDS" gene 2621978..2622646 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /label="ktrA gene" CDS 2622653..2623990 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium transporter ATPase" /protein_id="NP_390988.1" /db_xref="EnsemblGenomes-Gn:BSU31100" /db_xref="EnsemblGenomes-Tr:CAB15088" /db_xref="GOA:O32081" /db_xref="InterPro:IPR003445" /db_xref="InterPro:IPR004772" /db_xref="PDB:4J7C" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13956" /db_xref="UniProtKB/Swiss-Prot:O32081" /translation="MTLQKDKVIKWVRFTPPQVLAIGFFLTIIIGAVLLMLPISTTKP LSWIDALFTAASATTVTGLAVVDTGTQFTVFGQTVIMGLIQIGGLGFMTFAVLIVMIL GKKIGLKERMLVQEALNQPTIGGVIGLVKVLFLFSISIELIAALILSIRLVPQYGWSS GLFASLFHAISAFNNAGFSLWPDNLMSYVGDPTVNLVITFLFITGGIGFTVLFDVMKN RRFKTFSLHTKLMLTGTLMLNAIAMLTVFILEYSNPGTLGHLHIVDKLWASYFQAVTP RTAGFNSLDFGSMREGTIVFTLLLMFIGAGSASTASGIKLTTFIVILTSVIAYLRGKK ETVIFRRSIKYPIIIKALAVSVTSLFIVFLGIFALTITEQAPFLQIVFETFSAFGTVG LTMGLTPELTTAGKCIIIVIMFIGRIGPLTFVFSFAKTEQSNIRYPDGEVFTG*" /label="ktrB CDS" gene 2622653..2623990 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /label="ktrB gene" downshifts 2623976 /Source="Nicolas_upshifts" /id="D1606" /incds=0 /nref=9 /ntot=98 /MaxReadThrough="0.86883" /MaxDrop="3.37604" /score="25.8974852" /energy="-11.9" /TU="NA" /idTUdmin="U2411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2624026..2624289) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390989.1" /db_xref="EnsemblGenomes-Gn:BSU31110" /db_xref="EnsemblGenomes-Tr:CAB15089" /db_xref="GOA:O32082" /db_xref="InterPro:IPR008024" /db_xref="SubtiList:BG13955" /db_xref="UniProtKB/Swiss-Prot:O32082" /translation="MQKYRRRNTVAFTVLAYFTFFAGVFLFSIGLYNADNLELNEKGY YIAVMILVAVGAILTQKVTRDNAEDNEIIAEQEKRQNQSHIES*" /label="yubF CDS" gene complement(2624026..2624289) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /label="yubF gene" downshifts complement(2624044) /Source="Nicolas_upshifts" /id="D1607" /incds=0 /nref=237 /ntot=309 /MaxReadThrough="2.4577" /MaxDrop="7.13564" /score="30.2020977" /energy="-11.9" /TU="NA" /idTUdmin="U2412" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2624329..2624348) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2624331) /Source="Nicolas_upshifts" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2624361..2624368) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2624398..2625246) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /EC_number="3.2.1.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12525152, 16855244, 28448118, 28811162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12525152, 16855244, 28448118, 28811162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exoglucosaminidase" /protein_id="NP_390990.1" /db_xref="EnsemblGenomes-Gn:BSU31120" /db_xref="EnsemblGenomes-Tr:CAB15090" /db_xref="GOA:O32083" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR025987" /db_xref="SubtiList:BG13954" /db_xref="UniProtKB/Swiss-Prot:O32083" /translation="MARKKLKKRKLLISLFFLVSIPLALFVLATTLSKPIEISKETEE IDEQQVFIDSLSGHAQILYEKYHVLPSITIAQAILESDWGNSELAAKANNLFGVKGNY KGHHVTMETDEVEKGKRKTIRAKFRKYSTFFESMDDHAQLFVRGTSWNKKKYKPVLEA GNYKEAATALQTSGYATDPDYADKISAIVEKYDLDEYDEVNPSLKSVDLNASIKDSAV QDVWSKPSTDDRSIRLTSAQSYVGKDIKVVSKKQKGQSVWYQFQINDKLIGWIDDSAV EIKEAT*" /label="lytG CDS" gene complement(2624398..2625246) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /label="lytG gene" promotor_-10 complement(2625291..2625310) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2625301) /Source="Nicolas_upshifts" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2625325..2625332) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2625407..2626942) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28248504; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390991.1" /db_xref="EnsemblGenomes-Gn:BSU31130" /db_xref="EnsemblGenomes-Tr:CAB15091" /db_xref="GOA:O32084" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13953" /db_xref="UniProtKB/Swiss-Prot:O32084" /translation="MKTKHYWVISLLAVLAVGPGLMSNTALSSVQGLVQKTVGTSVFT SVNPILIGNMAFALLVPAGPLLRKKFGARPVYLASLPVFILGSLLIACSGDIALMAAG RFLQGAATGVMLMIMIPMLVLSFPIERRNYALLVLIGGFYGSVIIGTILGTIATSCGH WRWLFFIFGTLSLIGVAVSYFFLHDEHHGAADQEQPLDRAGILLSVFLAAASAVSFIF LQKWGLSSGYVWIGFGVTLCLLIGLLIVEYKVKNPFISIKLMLLPKPVLGLLIIAAGT ITVAVSLSAFQGLLRQMYDISQEHLILLSLTLLIGVAIAAILSALLYDKVGPGMLGII GGLILVFVNFQWLHIQDRSSLYMFAALFIMLAAGTGLTVAAGLMGAAMGGPLPDLVKR MTAVQFLRLFVYMGVPILIGFFTKKDAARQSGSVQDSMMTAYHDLFFISFILSVLLVC LSFCMNATGMGHKLAHKPHDKAKTAPEKPAVSAQGLSKATVKSYKVINDTEYRNALRN LQK*" /label="yubD CDS" gene complement(2625407..2626942) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /label="yubD gene" downshifts complement(2625416) /Source="Nicolas_upshifts" /id="D1608" /incds=0 /nref=45 /ntot=159 /MaxReadThrough="1.39941" /MaxDrop="4.26166" /score="-3.3162201" /energy="-5.7" /TU="NA" /idTUdmin="U2415" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 2626600..2626700 /Source="Nicolas_upshift_promotors" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2626660 /Source="Nicolas_upshifts" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2626726 /Source="Nicolas_upshifts" /id="D1609" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="0.0870599999999992" /MaxDrop="3.19459" /score="-1.6836786" /energy="-10.4" /TU="NA" /idTUdmin="U2416" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature complement(2626943..2627110) /Source="Nicolas_S_feature" /locus_tag="new_3193379_3193546_c" /HighExp="Cold, S8, G180, UNK1, C30, G135, S7, Lbexp, MG 25, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34877900000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1186" promotor_-10 complement(2627099..2627118) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2627110) /Source="Nicolas_upshifts" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2627112..2627989) /Source="Nicolas_S_feature" /locus_tag="new_3193548_3194425_c" /HighExp="G180, Cold, C30, G135, Paraq, Oxctl, S8, G150, H2O2, Heat" /AntisenseName="cdoA" /AntisenseCor="-2.3104546834536201E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1187" promotor_-35 complement(2627133..2627140) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2627352..2627361 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2627375..2627394 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2627375 /Source="Nicolas_upshifts" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="upshifts" CDS 2627427..2627912 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /EC_number="1.13.11.20" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10939241, 15699190, 16855246, 25307852, 26590284" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15699190, 16855246, 25307852, 26590284; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine dioxygenase" /protein_id="NP_390992.1" /db_xref="EnsemblGenomes-Gn:BSU31140" /db_xref="EnsemblGenomes-Tr:CAB15092" /db_xref="GOA:O32085" /db_xref="InterPro:IPR010300" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:3EQE" /db_xref="PDB:4QM8" /db_xref="PDB:4QM9" /db_xref="SubtiList:BG13952" /db_xref="UniProtKB/Swiss-Prot:O32085" /translation="MELYECIQDIFGGLKNPSVKDLATSLKQIPNAAKLSQPYIKEPD QYAYGRNAIYRNNELEIIVINIPPNKETTVHDHGQSIGCAMVLEGKLLNSIYRSTGEH AELSNSYFVHEGECLISTKGLIHKMSNPTSERMVSLHVYSPPLEDMTVFEEQKEVLEN S*" /label="cdoA CDS" gene 2627427..2627912 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /label="cdoA gene" S_feature 2627913..2628199 /Source="Nicolas_S_feature" /locus_tag="new_3194349_3194635" /HighExp="S6, S8, S7, BT, S5, G/S, C30, Pyr, C90, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.53171800000000002" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1188" tRNA complement(2628019..2628091) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala (GGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Ala1 tRNA" gene complement(2628019..2628091) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /label="trnSL-Ala1 gene" downshifts complement(2628034) /Source="Nicolas_upshifts" /id="D1610" /incds=0 /nref=37 /ntot=180 /MaxReadThrough="3.88031" /MaxDrop="4.38957" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2628078) /Source="Nicolas_upshifts" /id="D1611" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.34085" /MaxDrop="4.19639" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2628102..2628121) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2628122) /Source="Nicolas_upshifts" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2628136..2628139) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2628156 /Source="Nicolas_upshifts" /id="D1612" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.04964" /MaxDrop="3.22361" /score="-1.6836786" /energy="-10.4" /TU="U2416" /idTUdmin="U2416" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2628199..2629029) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /EC_number="3.6.1.27" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15138271, 15849754, 16850406, 27528508, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15138271, 15849754, 16850406, 27528508, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl-pyrophosphate phosphatase" /protein_id="NP_390993.1" /db_xref="EnsemblGenomes-Gn:BSU31150" /db_xref="EnsemblGenomes-Tr:CAB15093" /db_xref="GOA:P94507" /db_xref="InterPro:IPR003824" /db_xref="SubtiList:BG13951" /db_xref="UniProtKB/Swiss-Prot:P94507" /translation="MTLWELFVAAILGIVEGLTEYAPVSSTGHMIIVDDIWLKSSNLM SEEAANSFKVVIQLGSILAVAIVFKDRILNLLGLKKNITSDQEQGHKLSIAQIAVGLV PAAVLGFLFEDYIDEYLFSVKTVAIGLIAGAILMLFADWVNKRKTATDTLDRISYKQA IAVGLFQCLSLWPGFSRSGSTISGGVILGLNHRAAADFTFIMAMPIMMGASFLSLVKH WDSLSSDLMPFFIVGFICAFVVALFVVRFFLRLINKIKLVPFAIYRIILGVILLLIMM *" /label="uppP CDS" gene complement(2628199..2629029) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /label="uppP gene" downshifts complement(2628210) /Source="Nicolas_upshifts" /id="D1613" /incds=0 /nref=60 /ntot=208 /MaxReadThrough="3.0552" /MaxDrop="5.61932" /score="-4.25033697" /energy="-6.7" /TU="U2419" /idTUdmin="U2419" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2629030..2629121) /Source="Nicolas_S_feature" /locus_tag="new_3195466_3195557_c" /HighExp="dia15, H2O2, Salt, Etha, dia5, LBGtran, M0t90, Lbstat, Mt0, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1189" CDS complement(2629122..2630288) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16385049, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390994.1" /db_xref="EnsemblGenomes-Gn:BSU31160" /db_xref="EnsemblGenomes-Tr:CAB15094" /db_xref="GOA:O32086" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13950" /db_xref="UniProtKB/Swiss-Prot:O32086" /translation="METLQTWSGRFKRFFLDNKFVLFLLVLLLIGLNILVFTKTSFIF TPIIVLLKTISLPIILTGIVFYLLNPVVDFLERRRIRRIYSILLLYLLVIGLITITIV SIIPFLKEQIMSLIDNIPRYVDVVENQTKQLIGSNFVNQAQQTMNINISDLATKVSDQ AATIVNSTFTGVGNFIGALTEIIISIVTVPFILFYLLKDGRKLPVYILKFVPTRLKEQ TYTVLSEMNHRLSSYIRGQIIVSFCIGFLLFIGYLIIGLDYASLLAVIAACTSIVPYL GPTIAITPAIIIAIVTSPLMLLKLVIVWTIVQLIEGKLISPQIMGKNLHIHPITIIFL LLTAGKLFGVVGIILAIPGYAVAKVITTHLFDWFKMQSHLYDEEKNENTPGHKV*" /label="yubA CDS" gene complement(2629122..2630288) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /label="yubA gene" promotor_-35 2630284..2630288 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2630296..2630310 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2630312..2630331) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2630312 /Source="Nicolas_upshifts" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2630331) /Source="Nicolas_upshifts" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2630345..2630352) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2630410..2630417 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2630423 /Source="Nicolas_upshifts" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2630428..2630447 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2630470..2631456 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /EC_number="1.1.1.371" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12450853, 28043209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450853, 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol dehydrogenase (NADP+-dependent);biofilm formation" /protein_id="NP_390995.1" /db_xref="EnsemblGenomes-Gn:BSU31170" /db_xref="EnsemblGenomes-Tr:CAB15095" /db_xref="GOA:O05265" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12388" /db_xref="UniProtKB/Swiss-Prot:O05265" /translation="MIRFAIIGTNWITDRFLESAADIEDFQLTAVYSRSAERAGEFAA KHNAAHAFSDLQEMAASDCFDAVYIASPNALHKEQAVLFMNHGKHVLCEKPFASNTKE TEEMISAAKANGVVLMEAMKTTFLPNFKELKKHLHKIGTVRRFTASYCQYSSRYDAFR SGTVLNAFQPELSNGSLMDIGVYCIYPAVVLFGAPKDVKANGYALSSGVDGEGTVILS YDGFEAVLMHSKISTSYAPAEIQGEDGTIVIDTIHRPERVEIRYRDGRLENIAIPDPK PAMFYEAEEFVTLIKENKLESEENTFERSLTTAKIMEEARKQMGIVYPADQA*" /label="iolU CDS" gene 2630470..2631456 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /label="iolU gene" downshifts 2631427 /Source="Nicolas_upshifts" /id="D1614" /incds=0 /nref=30 /ntot=279 /MaxReadThrough="1.83109" /MaxDrop="4.96985" /score="21.8997198" /energy="-15.1" /TU="NA" /idTUdmin="U2420" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2631497..2632771) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /EC_number="5.3.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960106, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960106, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose isomerase" /protein_id="NP_390996.1" /db_xref="EnsemblGenomes-Gn:BSU31180" /db_xref="EnsemblGenomes-Tr:CAB15096" /db_xref="GOA:O05264" /db_xref="InterPro:IPR009308" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG12387" /db_xref="UniProtKB/Swiss-Prot:O05264" /translation="MTIKANYDSAKQAYEKWGIDVEEALRQLEQVPISIHCWQGDDIE GFEVNKGELSGGIDVTGNYPGKAQTPEELRRDLEKALSLIPGKHRVNLHAIYAETNRE AVERDELKPQHFENWVKWAKNLGLGLDFNPTLFSHEKAADGLTLSHPDPDIREFWIRH CIACRRIGEYFGKELGTPCLTNIWIPDGYKDIPSDRLTPRKRLKESLDRIFSEEISEQ HNLDSIESKLFGLGSESYVVGSHEFYLAYALTNHKLCLLDTGHFHPTETVSNKISSML LYTDKLALHVSRPVRWDSDHVVVLDDELREIALEIVRNHALEKVAIGLDFFDASINRV AAWTIGTRNMIKALLYALLLPNGYLKQLQEEGRYTERLALMEEFKTYPFGAIWDSYCE QMGVPVKEAWLYDIKEYEQQVLLKRKASSPIV*" /label="rhaA CDS" gene complement(2631497..2632771) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /label="rhaA gene" downshifts complement(2631510) /Source="Nicolas_upshifts" /id="D1615" /incds=0 /nref=3 /ntot=29 /MaxReadThrough="0.802" /MaxDrop="4.45322" /score="14.0829844" /energy="-12.6" /TU="NA" /idTUdmin="U2421" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2632797..2633111) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /EC_number="5.1.3.32" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15576793, 15876375, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576793, 15876375, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose mutarotase" /protein_id="NP_390997.1" /db_xref="EnsemblGenomes-Gn:BSU31190" /db_xref="EnsemblGenomes-Tr:CAB15097" /db_xref="GOA:O05263" /db_xref="InterPro:IPR008000" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR013448" /db_xref="SubtiList:BG12386" /db_xref="UniProtKB/Swiss-Prot:O05263" /translation="MKRKASIMFVHQDKYEEYKQRHDDIWPEMAEALKAHGAHHYSIF LDEETGRLFAYLEIEDEEKWRKMADTEVCQRWWKSMAPLMKTNSDFSPVAIDLKEVFY LD*" /label="rhaM CDS" gene complement(2632797..2633111) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /label="rhaM gene" CDS complement(2633129..2634586) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /EC_number="2.7.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16674975, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16674975, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnulokinase" /protein_id="NP_390998.1" /db_xref="EnsemblGenomes-Gn:BSU31200" /db_xref="EnsemblGenomes-Tr:CAB15098" /db_xref="GOA:O05262" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR013449" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG12385" /db_xref="UniProtKB/Swiss-Prot:O05262" /translation="MIYTAIDVGASSGRIMVGELNEGKLDIQEIHRFANGFSQRDGHC LWDIDHLLKQILQGLQKVKTLGYEHCTVGIDTWAVDYVLLDEKGDRLREAISYRDRRT DHTIDKLEHTLSKAAIYQKTGIQFQPFNTIYQLFEEDRELLKKTDKIMMIPDYLGYCL TGKAVTEITNVSTTQLLNVSTGNLDPELLEAVSVLEQQFAPLTEPGCELGKLRNEWFP DYDLPACKVMTVATHDTASAVIAAPGVNDGWAYISSGTWSLIGVENKTPIITDLALEN NYTNERGANNTIRFLKNIIGMWVIQEVKQQLQADYSFQQLAEEAKKTEPFQQFINLND KRFLNPENMIKEIQHYCRQTRQKIPRTAGELACCIYSNLAIIYAIAIKELETITEKPI EQFHIIGGGARNDFLNQLTADMSGKAVYAGPIEATATGNLLMQMIAAKEVKDIKEARQ VVRNSFPIKVFTPKDIDRSTIIQSFQQTVLKALSK*" /label="rhaB CDS" gene complement(2633129..2634586) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /label="rhaB gene" CDS complement(2634591..2635367) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11496004, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11496004, 26712933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the rhamnose operon(RhaR / l-rhamnulose-1-phosphate)" /protein_id="NP_390999.1" /db_xref="EnsemblGenomes-Gn:BSU31210" /db_xref="EnsemblGenomes-Tr:CAB15099" /db_xref="GOA:O05261" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12384" /db_xref="UniProtKB/Swiss-Prot:O05261" /translation="MLVAERQQKIVEIVNMRSSIRVSELSDIFSVTEETIRRDLEKLE KEHKLSRSHGGAVSIQQKESEIHFSEREITNVIEKKAIAHEAAKYVKSGDRIILDAST TAWYMAKILPDIELTVITNSMKAAIELSNKENISVISTGGILLEKSLSFAGPLAERSL ETYHVNKTFLSCKGFDVHNGMSDSNEWQALLKKRMIERSDQTILMADSSKWGNREFSH IASLQDVSRLITDSGLDPASVKALEDKKVKVTAVPLSKRG*" /label="rhaR CDS" gene complement(2634591..2635367) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /label="rhaR gene" misc_feature complement(2635401..2635420) /Source="Nicolas_upshift_promotors" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2635417) /Source="Nicolas_upshifts" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2635424..2637493) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /EC_number="1.1.1.-" /EC_number="4.1.2.19" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24391637, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24391637, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional rhamnulose-1-phosphate aldolase/alcohol dehydrogenase" /protein_id="NP_391000.1" /db_xref="EnsemblGenomes-Gn:BSU31220" /db_xref="EnsemblGenomes-Tr:CAB15100" /db_xref="GOA:P40747" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR013454" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG10947" /db_xref="UniProtKB/Swiss-Prot:P40747" /translation="MVKHIWDSERAAQLPKGVEELVYRSNLIGSDRTVCNWGGGNTSM KTTEKDFRGREIEVMWVKGSGSDLATMKAHNFSGLKLDDIRPLIKRDQMPDEEMVDYL SHCMIDSKHPRPSIETLLHAFLPYKHVDHTHPDAIISICCADNGKQIAEDIYGNRFVW VPYVRPGFTLSKMIAEGVANNPHAELVLMEKHGLVTWGETSETCYQKTISIIQEAEQY INDRINQHEVFGGKRYQPLPEDKRKQILAGIMPVIRGAVSEEKKMILSYDDHDDVLEF VNSVQAPALSQIGAACPDHLVHTKRVPLYIDWNPETQDVHKLADLIKSGVETFTSEYQ AYFTRNQQDGDQIFESAPRVILIPGIGMVNTGKSYAMSKVSGALYRRAIAVMKGATAL GQFVSLHENESYHVEYWPLELYKLTLAPPEAEFSRKVALITGGAGGIGSAACRRFAAE GGHVIVADLNIEGAQKIAGEINDAYGKGRAMAVKMDVTKEEDVQSAFERAALAYGGID IVVNNAGLATSSPFDETSLKEWNLNMNVLGTGYFLVAREAFKQMKHQNRGGSMVFVGS KNSVYAGKNASAYSSVKALETHLARCIAAEGGEFGIRVNSVLPDAVLQGSAIWGSSWR EERAAAYGIEPDQLEEHYRKRTALLVNIYPEDIAEAIAFFASSKAEKTTGCMITVDGG VPAAFTR*" /label="rhaE CDS" gene complement(2635424..2637493) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /label="rhaE gene" promotor_-10 complement(2637526..2637545) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2637538) /Source="Nicolas_upshifts" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2637559..2637565) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2637631..2639619) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391001.1" /db_xref="EnsemblGenomes-Gn:BSU31230" /db_xref="EnsemblGenomes-Tr:CAB15101" /db_xref="GOA:P39217" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10862" /db_xref="UniProtKB/Swiss-Prot:P39217" /translation="MGKFIQWIKQPSISKPLIAAFLAVLILPVGVLAYFSYQSAWNAL DRELISSAKGNVEELNSTLQNKLEDKVKAIDYYSETVDKDILLGKNKTLLKEKFKQYT TLNDDVGAIYAASEDKKLYKYPDSGVPKGFDPTGRDWYKQAVAEKGQAVFSEPYTDEA TGDIVVTISKQLKDGSGVIALDLNLDEVLTASKRIKIGKEGFAFITTGNKKYIAHPTI KPGTTGSGDWTNQVYSKKEGSFEYTFEGKEKKMAFTTNKLTGWKIAGTYFVSELQDAS SPVLNTAVIILCVSIVIGGILILYIIRAITKPLRKLVSTSAKISSGDLTEVIDIHSKN EFGQLGESFNEMSASLRSVIGVIQTSVENVASSSEELTASAAQTSKATEHITLAIEQF SDGNEAQSEKLETSSNHLSQMNEGISKVAQASSTITKSSIQSSEAAGSGEKLVEHTVG QMKTIDQSVQKAEAVVKGLETKSQDITSILNVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIQEIVREISTSLSMFQSVNHEVKEGLQITDQ TAESFKQIYEMTTQISGELQNLNATVEQLSAGSQEVSSAVEDISAVAKESSAGIQDIA ASAEEQLASMEEISSSAETLANMAEELQDITKKFKIES*" /label="tlpB CDS" gene complement(2637631..2639619) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /label="tlpB gene" downshifts complement(2637650) /Source="Nicolas_upshifts" /id="D1616" /incds=0 /nref=108 /ntot=174 /MaxReadThrough="3.32915" /MaxDrop="6.75141" /score="18.7221191" /energy="-8.3" /TU="NA" /idTUdmin="U2423" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2639623..2639630 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2639640..2639658) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2639646..2639665 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2639653) /Source="Nicolas_upshifts" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="upshifts" upshifts 2639662 /Source="Nicolas_upshifts" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2639672..2639679) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2639728 /Source="Nicolas_upshifts" /id="D1617" /incds=0 /nref=4 /ntot=11 /MaxReadThrough="1.04089" /MaxDrop="4.2056" /score="13.4355481" /energy="-10.7" /TU="NA" /idTUdmin="U2424" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2639733..2641718) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 9721285, 12011078" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 9721285, 12011078; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391002.2" /db_xref="EnsemblGenomes-Gn:BSU31240" /db_xref="EnsemblGenomes-Tr:CAB15102" /db_xref="GOA:P39214" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10861" /db_xref="UniProtKB/Swiss-Prot:P39214" /translation="MKKILQLIKQRSITRKLLVSFLSILIIPVVILAIFAYQSASSSL DRQMMGSALENVQQLNEIINTSIGEKENSADYFSEWLTKEKYNAKSNASIAEKFSQYI SINKDVESIYTSDTKGHFTRYPDLPMPSGYNPVERDWYKKAVANKGKVVITDPYKTAS TNTMVVTIAQQTKDGSGVIAINMTIENLLKTTKKVNIGTQGYAFIMTKDKKVVAHPNE QSGTELKGDWLDKMLSADKGDFQYTMDGDKKKMAFDTNKLTGWKIGGTMYLDEIHEAA QPVLHLALIVLAAAIIIGIIVMTLIIRSITTPLKQLVGSSKRISEGDLTETIDIRSKD ELGELGKSFNNMASSLRSLIHAIQDSVDNVAASSEELTASAAQTSKATEHITLAIEQF SNGNEKQNENIETAAEHIYQMNDGLTNMAQASEVITDSSVQSTEIASEGGKLVHQTVG QMNVIDKSVKEAEQVVRGLETKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIIEIVKEINTSLGMFQSVNQEVQTGLDITDK TEMSFKRISEMTNQIAGELQNMSATVQQLSASSEEVSGASEHIASISKESSAHIQDIA ASAEEQLASMEEISSSAETLSSMAEELRDMTKRFKIE*" /label="mcpA CDS" gene complement(2639733..2641718) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /label="mcpA gene" downshifts complement(2639738) /Source="Nicolas_upshifts" /id="D1618" /incds=0 /nref=196 /ntot=232 /MaxReadThrough="3.11319" /MaxDrop="7.54297" /score="40.6270404" /energy="-13.6" /TU="U2425" /idTUdmin="U2425" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2641739..2641757) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2641754) /Source="Nicolas_upshifts" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2641756..2641843) /Source="Nicolas_S_feature" /locus_tag="new_3208192_3208279_c" /HighExp="GM 150, T0.0H, T-1.40H, T-0.40H, MG 150, T-5.40H, T-3.40H, T-1.10H, T-2.40H, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1190" promotor_-35 complement(2641771..2641778) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2641844..2643832) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871, 26522943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871, 26522943; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (membrane curvature dependent localisation)" /protein_id="NP_391003.1" /db_xref="EnsemblGenomes-Gn:BSU31250" /db_xref="EnsemblGenomes-Tr:CAB15103" /db_xref="GOA:P39216" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10860" /db_xref="UniProtKB/Swiss-Prot:P39216" /translation="MKKTLTTIRRSSIARRLIISFLLILIVPITALSVSAYQSAVASL DVQMTQSAKENVQILDHIIDDKISTTEKSLAYFSDWATAEKFQDKKKTELKQEFKQFI QMNDNVAAVFSSGKDGDFTRYPYADMPSDFNALERDWYKEAMANKGKTIVTEPYESIS SGKMVVTIARQTVDGSGVVAIDMKIDDLVTTAKGINIGKEGYAFILSQNKKVIAYSGE KAGTELKGDWVDKLYKDKSGDFEYTYKGKKKKMAFATSQTTGWKISGTMYANEIHDAA SRVLIMASIVLAIAIGAGMTAIYFVIRSITKPLRRIVASAEKISEGDLTETIEINSKD ELGVLSESFNHMAHSLRSLIHGIKDSVEHVASSSEELTASADQTSRATEHITMAIEQF SNGSESQSEKIETTTEQINEMNDGLAELARAAAVITETSADSTEVSSKGETLVQKTAG QMNTIDHSVKAAEQVVKGLEIKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIESLISEIVKEIHTSLNVLQSVNKEVETGLVMTDE TKQSFKHISQMTNQIASELQNMNATVEELSAGAQEISAASNDITAISKESSDGIQDIA ASAEEQLASMEEISSSALTLERMSEELRDLTKQFKVDK*" /label="tlpA CDS" gene complement(2641844..2643832) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /label="tlpA gene" promotor_-10 complement(2643857..2643875) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-10" upshifts complement(2643872) /Source="Nicolas_upshifts" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="upshifts" promotor_-35 complement(2643889..2643896) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-35" CDS complement(2644009..2645997) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391004.2" /db_xref="EnsemblGenomes-Gn:BSU31260" /db_xref="EnsemblGenomes-Tr:CAB15104" /db_xref="GOA:P39215" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10859" /db_xref="UniProtKB/Swiss-Prot:P39215" /translation="MKTFINWLKKPSISKKLIVSFIAILIIPILILEFSSYRSASGKL DQEIMGNAKNSVDTFNTTVTNDLGEKAKAVTFFSESLKRSAFKGKSNQEEIKAKFSQY VSINQGVARIYGGADNGTYVQAPKEKLPEGYDPRQRPWYQDAMKAGGEIVVTDPYVAA SDGSMVITIAQELKDGSGVVAMDITIDKLLEQMKQIKVGKEGYAFIATKNKTYVAHKN HKAGEKLSGDWVAKMYANDSGELQYTLNNEDKKMTYTTNELTGWKIAGTMYMDEIKDA SKSVLTTGMIVLIASIVAGGILILFIVRSITKPLKRLVQSSKTISRGDLTETIEIHSK DELGELGESFNEMGQSLRSLISAIQDSVNNVAASSEQLTASAGQTSKATEHITMAIEQ FSNGNEEQSEKVESSSHQLNLMNEGLQQVSQTSSDITKASIQSTEIAGTGEKFVQQTV GQMNSINQSVQQAEAVVKGLEGKSKDITSILRVINGIADQTNLLALNAAIEAARAGES GRGFSVVAEEVRKLAVQSADSAKEIEKLIQEIVAEIDTSLHMFKEVNQEVQSGLVVTD NTKESFQSIFSMTNEIAGKLQTMNSTVEQLSDRSQHVSAAVSGIADVSKESSASIQDI AASAEEQLASMEEISSSATTLAQMAEELRDLTKQFKIE*" /label="mcpB CDS" gene complement(2644009..2645997) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /label="mcpB gene" downshifts complement(2644028) /Source="Nicolas_upshifts" /id="D1619" /incds=0 /nref=136 /ntot=224 /MaxReadThrough="3.76161" /MaxDrop="7.09773" /score="30.8363643" /energy="-10.7" /TU="U2427" /idTUdmin="U2427" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2646018..2646036) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2646039) /Source="Nicolas_upshifts" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2646049..2646056) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2646099..2646108 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2646122..2646141 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2646125 /Source="Nicolas_upshifts" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="upshifts" CDS 2646155..2646892 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /EC_number="2.3.2.13" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9692191, 16267299, 16751597, 16936016, 18249137, 26322858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9692191, 16267299, 16751597, 16936016, 18249137, 26322858; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein-glutamine gamma-glutamyltransferase (transglutaminase)" /protein_id="NP_391005.1" /db_xref="EnsemblGenomes-Gn:BSU31270" /db_xref="EnsemblGenomes-Tr:CAB15105" /db_xref="GOA:P40746" /db_xref="InterPro:IPR020916" /db_xref="PDB:4P8I" /db_xref="PDB:4PA5" /db_xref="SubtiList:BG10946" /db_xref="UniProtKB/Swiss-Prot:P40746" /translation="MIIVSGQLLRPQDIENWQIDQDLNPLLKEMIETPVQFDYHSIAE LMFELKLRMNIVAAAKTLHKSGAKFATFLKTYGNTTYWRVSPEGALELKYRMPPSKAI RDIAENGPFYAFECATAIVIIYYLALIDTIGEDKFNASFDRIILYDWHYEKLPIYTET GHHFFLGDCLYFKNPEFDPQKAQWRGENVILLGEDKYFAHGLGILNGKQIIDKLNSFR KKGALQSAYLLSQATRLDVPSLFRIVR*" /label="tgl CDS" gene 2646155..2646892 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /label="tgl gene" promotor_-10 complement(2646180..2646199) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-10" upshifts complement(2646188) /Source="Nicolas_upshifts" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="upshifts" promotor_-35 complement(2646215..2646219) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-35" S_feature 2646893..2649713 /Source="Nicolas_S_feature" /locus_tag="new_3213329_3216149" /HighExp="S6, S8, S7, BT, S5, C30, B36, Pyr, BC, C90" /AntisenseName="yugT" /AntisenseCor="0.63350809138227804" /AntisenseRegPval="-30.9" /CDS_PredictionProba="0.61985900000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1191" CDS complement(2646906..2647160) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097776.1" /db_xref="EnsemblGenomes-Gn:BSU31279" /db_xref="EnsemblGenomes-Tr:CAX52682" /db_xref="UniProtKB/Swiss-Prot:C0H3Q3" /translation="MNILQYSYKKRGKIEFVFEGWPHSKVTMVPIKGYYFVRFIKWSS QDPIVTRNDLEKMEWAANQYFGTAPFYRKRKAFETPSSGK*" /label="yuzH CDS" gene complement(2646906..2647160) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /label="yuzH gene" downshifts complement(2646932) /Source="Nicolas_upshifts" /id="D1620" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="2.39206" /MaxDrop="2.92958" /score="-2.51333596" /energy="-14.7" /TU="NA" /idTUdmin="U2430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2647161..2647417) /Source="Nicolas_S_feature" /locus_tag="new_3213597_3213853_c" /HighExp="Etha, Sw, Salt, Gly, BC, M9-stat, Lbstat, Heat, LPhT, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37980700000000001" /TUshortSig="SigB" /TUshortPSig="0.969" /TUlongSig="NA" /TUlongPSig="NA" /label="S1192" CDS complement(2647418..2647816) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391006.2" /db_xref="EnsemblGenomes-Gn:BSU31280" /db_xref="EnsemblGenomes-Tr:CAB15106" /db_xref="InterPro:IPR001602" /db_xref="InterPro:IPR035917" /db_xref="SubtiList:BG12373" /db_xref="UniProtKB/Swiss-Prot:O05243" /translation="MLKTLQIKTTKRDEMIDITREVEAFLQETGITSGAALIYCPHTT AGITINENADPDVKKDMLRRFDEVYPWEHELDRHMEGNTAAHMKSSTVGASQHVIVEN GRLILGTWQGIYFCEFDGPRTRTCYIKMMG*" /label="yugU CDS" gene complement(2647418..2647816) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /label="yugU gene" CDS complement(2647776..2647910) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514000.1" /translation="MFYRVYESGLTGKKRTQNELSDESGQTKGETNAENTANQNNQTR *" /label="hypothetical protein CDS" gene complement(2647776..2647910) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /label="gene" promotor_-10 complement(2647859..2647878) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2647866) /Source="Nicolas_upshifts" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2647893..2647899) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2647936..2649600) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1761534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-1,6-glucosidase" /protein_id="NP_391007.2" /db_xref="EnsemblGenomes-Gn:BSU31290" /db_xref="EnsemblGenomes-Tr:CAB15118" /db_xref="GOA:O05242" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG12372" /db_xref="UniProtKB/Swiss-Prot:O05242" /translation="MKKAWWKEAVVYQIYPRSFKDSNGDGIGDIQGIRTKLSYIKELG ADVIWICPLYDSPNADNGYDIRDYQNILSEFGTMEDFDELLGDIHDLDMKLIMDLVVN HTSDEHPWFIESRSSIHSEKRDWYIWKDGKNGKTPNNWESIFGGPAWEYDQKTSQYYL HLFDKKQPDLNWENEKVRNAVYDMINWWLDKGIDGFRVDAITHIKKKEGFPDMPNPKG LDYVPSFPYHMNADGIMDLLTELKENTFSRYPIMTVGEANGVAAKEAADWAGEKNGIF SMIFQFEHLGLWDVEINESIDIVAFKRILTDWQDSLEGIGWNALFMENHDQPRSVSVW GDDGVYLKESAKALSAVYFLMKGTPFIYQGQELGMTNVAFPSIEDYDDVALKRLYETK TAKGTSHEDVMKIVWKKGRDNSRTPMQWNAGPYAGFSEAKPWIGINENYKWLNAEAQK NDKTSVYHFYKSLIKLRQTYDVFINGTYELILPEDQQIFAYLRKNESHTALIAANLTG TPALFRHSGLPLSSDALVLSNIETEPHKHMTSVLLKPYEARIYLWC*" /label="yugT CDS" gene complement(2647936..2649600) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /label="yugT gene" downshifts complement(2647952) /Source="Nicolas_upshifts" /id="D1621" /incds=0 /nref=13 /ntot=38 /MaxReadThrough="1.79723" /MaxDrop="4.64379" /score="19.4176812" /energy="-6.5" /TU="NA" /idTUdmin="U2432" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2648908..2648927) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2648913) /Source="Nicolas_upshifts" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2648941..2648948) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2649625..2649643) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2649642) /Source="Nicolas_upshifts" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2649659..2649664) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2649727..2651016) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_391008.2" /db_xref="EnsemblGenomes-Gn:BSU31300" /db_xref="EnsemblGenomes-Tr:CAB15119" /db_xref="GOA:O05241" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12371" /db_xref="UniProtKB/Swiss-Prot:O05241" /translation="MLILQLIAIFVLIGITAVFVAAEFAIVKIRGSKINQLIESGDSR ALAAHKIISNLDEYLSACQLGITITALGLGWLGEPTFERFLHPLFTMTGIPEPFNHIV TFVVAFIIVTFLHVVMGELAPKTVSIQKAEAVSLWIAKPLIWFYKITYPFIKALNGSA SFLVKLFGFHSVKEHQVVISEEELRLILSESYEKGEINQSEFRYVNKIFEFDNRVARE IMIPRTEIAVISLEQSLEEAIHHIINERYTRYPVIKDDKDHILGIINSKDMFKAYFLG QPIKLNQIMRPVIRVIESIPVQQLLIRMQKERIHMAILVDEYGGTAGLVTVEDIIEEI VGEIRDEYDQDETPHILKKGEHHYVMDGKALIDEVNDLLDIAIENEEIDTIAGWLLTQ KMELKAGDVIHAEGCEFKILDAEDHHIRFVEIKKTDF*" /label="yugS CDS" gene complement(2649727..2651016) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /label="yugS gene" downshifts complement(2649736) /Source="Nicolas_upshifts" /id="D1622" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.89237" /MaxDrop="3.67001" /score="3.60520478" /energy="-7.6" /TU="NA" /idTUdmin="U2434" /TUdmin=13 /isTUend="TRUE" /label="downshifts" promotor_-35 2650545..2650551 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2650565..2650583 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2650571 /Source="Nicolas_upshifts" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="upshifts" S_feature 2650575..2651227 /Source="Nicolas_S_feature" /locus_tag="new_3217011_3217663" /HighExp="Etha, Sw, Gly, Salt, BC, B60, Heat, S8, B36, HiTm" /AntisenseName="yugS" /AntisenseCor="0.12310225183111501" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1193" CDS complement(2651060..2651737) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16704729, 16850406, 24383880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent protease/peptidase" /protein_id="NP_391009.1" /db_xref="EnsemblGenomes-Gn:BSU31310" /db_xref="EnsemblGenomes-Tr:CAB15120" /db_xref="GOA:O05248" /db_xref="InterPro:IPR007395" /db_xref="SubtiList:BG12370" /db_xref="UniProtKB/Swiss-Prot:O05248" /translation="MLFIFLTIAALGLSFWAQFKVKSNFEKYSKVEASSGRTGAETAR RILDINGLYDVPVEPVRGTLTDHYDPTRRVVRLSEPVYYGRSISAISVASHEVGHALQ HQESYGALVLRHKIFPVVNFASGVAPLLFLGGMLLGSLNLIGLGIILFSAAVFFQLIT LPVEFNASSRAKQIIVSEGFIRNNEENGVNKVLSAAALTYVAAALVSLFELLRFVMIF LNGRDEN*" /label="yugP CDS" gene complement(2651060..2651737) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /label="yugP gene" downshifts complement(2651070) /Source="Nicolas_upshifts" /id="D1623" /incds=0 /nref=153 /ntot=249 /MaxReadThrough="3.51629" /MaxDrop="4.854" /score="33.0420688" /energy="-13" /TU="U2434,U2435" /idTUdmin="U2435" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" S_feature 2651412..2652088 /Source="Nicolas_S_feature" /locus_tag="new_3217848_3218524" /HighExp="Sw, S8, Salt, BC, S7, Etha, Gly, B36, B60, LPhT" /AntisenseName="yuzI" /AntisenseCor="0.20035821815170399" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1194" promotor_-10 complement(2651772..2651791) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2651779..2652042) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16704729; Product type f : factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097777.1" /db_xref="EnsemblGenomes-Gn:BSU31319" /db_xref="EnsemblGenomes-Tr:CAX52683" /db_xref="GOA:C0H3Q4" /db_xref="UniProtKB/Swiss-Prot:C0H3Q4" /translation="MTIFQRTIVVLIGTQLAASAVILFIFDLNSYNHFSGSFSWLHFL KELAGSFAFYLFSAGLFFLLIGLCAPSRKKKRISVHEKENSLK*" /label="yuzI CDS" gene complement(2651779..2652042) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /label="yuzI gene" upshifts complement(2651793) /Source="Nicolas_upshifts" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2651805..2651812) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2652054..2652072) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2652068) /Source="Nicolas_upshifts" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2652088..2652093) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2652089..2652421 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15731457, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15731457, 23737939, 25297828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="atypical membrane-integrating regulator of biofilm formation (Mistic protein)" /protein_id="YP_003097778.1" /db_xref="EnsemblGenomes-Gn:BSU31321" /db_xref="EnsemblGenomes-Tr:CAX52684" /db_xref="GOA:Q5BU39" /db_xref="InterPro:IPR021078" /db_xref="PDB:1YGM" /db_xref="UniProtKB/Swiss-Prot:Q5BU39" /translation="MFCTFFEKHHRKWDILLEKSTGVMEAMKVTSEEKEQLSTAIDRM NEGLDAFIQLYNESEIDEPLIQLDDDTAELMKQARDMYGQEKLNEKLNTIIKQILSIS VSEEGEKE*" /label="mstX CDS" gene 2652089..2652421 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /label="mstX gene" promotor_-35 2652106..2652112 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2652127..2652144 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2652138 /Source="Nicolas_upshifts" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="upshifts" CDS 2652418..2653404 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16704729, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16704729, 23737939, 25297828; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium channel protein involved in biofilm formation" /protein_id="NP_391010.3" /db_xref="EnsemblGenomes-Gn:BSU31322" /db_xref="EnsemblGenomes-Tr:CAB15121" /db_xref="GOA:Q795M8" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR013099" /db_xref="InterPro:IPR028325" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12369" /db_xref="UniProtKB/Swiss-Prot:Q795M8" /translation="MKSNRIFISWLRWPLFIRIGVIILCLILLFGQIIYILEPKQFTS VFEGIWWAVVTVSTVGYGDYVPHTPLGQAAGILLILSGASFVTAYFATLSAAAFSRQH RYIEGKVAYKGRDHIILIGWNEKTNRLLKDLQLAAPSKTVVLIDESLTEGPLIENVHF IRGHAADDGTLKRANITEAESVMITADQYKSETDADMLSVLTLLSVKGLNPLAYCIVE ILTDRFVTNAERAGANQIIGTSEFISRAMLQHYQVKLRPSKQQNGIKLTLDQHVELLA VPDELKGAAYKTCVLYFLDHNTTIIGIQKKEGPMLSPPLTYKVLETDQFLAI*" /label="kbfO CDS" gene 2652418..2653404 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /label="kbfO gene" downshifts complement(2653379) /Source="Nicolas_upshifts" /id="D1624" /incds=0 /nref=44 /ntot=128 /MaxReadThrough="0.617940000000001" /MaxDrop="4.76695" /score="21.5904825" /energy="-11.3" /TU="NA" /idTUdmin="U2437" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2653401..2653805) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391011.1" /db_xref="EnsemblGenomes-Gn:BSU31330" /db_xref="EnsemblGenomes-Tr:CAB15122" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG12368" /db_xref="UniProtKB/Swiss-Prot:O05246" /translation="MIPIPSAIDGQSFLLQELEQVMKPLGYVINGGWEYDHGYFDYKI DDRDGYLFLRIPVNAVQGSLDERGAAVRIGTPFMLRQVFQADVDDHAEGGPFQSLFNQ FSEPERRDAEIDPAFLDIGASLVKELEDVLLH*" /label="yugN CDS" gene complement(2653401..2653805) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /label="yugN gene" S_feature complement(2653806..2653864) /Source="Nicolas_S_feature" /locus_tag="new_3220242_3220300_c" /HighExp="M0t90, M40t90, S6, S8, S7, T0.30H, Lbstat, M9-stat, T1.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-, SigA" /TUshortPSig="0.686, 0.141, 0.984" /TUlongSig="SigA" /TUlongPSig="0.988" /label="S1195" CDS complement(2653865..2654236) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391012.1" /db_xref="EnsemblGenomes-Gn:BSU31340" /db_xref="EnsemblGenomes-Tr:CAB15123" /db_xref="GOA:O05245" /db_xref="SubtiList:BG12367" /db_xref="UniProtKB/Swiss-Prot:O05245" /translation="MFMKQLVKHLIIAGFSAAILSFLISFDAVYTGFSSSFGGTLSHF FIHSFLLIGLPLALFTDAVHRILHLKRTHTLFTKLGLYATVVYVSWDSAVWLAAAMAV YFLIECAFFPVGRAKETTISM*" /label="yugM CDS" gene complement(2653865..2654236) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /label="yugM gene" CDS complement(2654295..2655647) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /EC_number="5.3.1.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4214896, 4275311, 11489127, 19052382, 21453533, 22720735, 24705866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate isomerase" /protein_id="NP_391013.2" /db_xref="EnsemblGenomes-Gn:BSU31350" /db_xref="EnsemblGenomes-Tr:CAB15124" /db_xref="GOA:P80860" /db_xref="InterPro:IPR001672" /db_xref="InterPro:IPR018189" /db_xref="InterPro:IPR035476" /db_xref="InterPro:IPR035482" /db_xref="SubtiList:BG12366" /db_xref="UniProtKB/Swiss-Prot:P80860" /translation="MTHVRFDYSKALTFFNEHELTYLRDFVKTAHHNIHEKTGAGSDF LGWVDLPEHYDKEEFARIKKSAEKIKSDSDVLLVVGIGGSYLGARAAIEALNHAFYNT LPKAKRGNPQVIFIGNNISSSYMRDVMDLLEDVDFSINVISKSGTTTEPAIAFRIFRK LLEEKYGKEEAKARIYATTDKERGALKTLSNEEGFESFVIPDDVGGRYSVLTAVGLLP IAVSGVNIDDMMKGALDASKDFATSELEDNPAYQYAVVRNVLYNKGKTIEMLINYEPA LQYFAEWWKQLFGESEGKDEKGIYPSSANYSTDLHSLGQYVQEGRRDLFETVLNVEKP KHELTIEEADNDLDGLNYLAGKTVDFVNKKAFQGTMLAHTDGNVPNLIVNIPELNAYT FGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGFEEKKAELEKRLED *" /label="pgi CDS" gene complement(2654295..2655647) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /label="pgi gene" downshifts complement(2654306) /Source="Nicolas_upshifts" /id="D1625" /incds=0 /nref=90 /ntot=198 /MaxReadThrough="6.86736" /MaxDrop="4.4585" /score="24.139293" /energy="-16.8" /TU="U2437,U2438,U2439" /idTUdmin="U2441" /TUdmin=19 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2654462..2654480) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2654479) /Source="Nicolas_upshifts" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2654496..2654501) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2655620) /Source="Nicolas_upshifts" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2655623..2655634) /Source="Nicolas_upshift_promotors" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2655679..2655698) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2655685) /Source="Nicolas_upshifts" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2655687..2655758) /Source="Nicolas_S_feature" /locus_tag="new_3222123_3222194_c" /HighExp="Etha, H2O2, Paraq, Oxctl, G180, G150, dia5, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.988" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1196" promotor_-35 complement(2655713..2655716) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2655759..2656931) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 1809209, 2673038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase subunit" /protein_id="NP_391014.1" /db_xref="EnsemblGenomes-Gn:BSU31360" /db_xref="EnsemblGenomes-Tr:CAB15125" /db_xref="GOA:O05240" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12365" /db_xref="UniProtKB/Swiss-Prot:O05240" /translation="MENFTYYNPTKLIFGKGQLEQLRKEFKRYGKNVLLVYGGGSIKR NGLYDQVTGILKEEGAVVHELSGVEPNPRLATVEKGIGLCREHDIDFLLAVGGGSVID CTKAIAAGVKYDGDAWDIFSKKVTAEDALPFGTVLTLAATGSEMNPDSVITNWETNEK FVWGSNVTHPRFSILDPENTFTVPENQTVYGMVDMMSHVFEQYFHNVENTPLQDRMCF AVLQTVIETAPKLLEDLENYELRETILYAGTIALNGTLQMGYFGDWASHTMEHAVSAV YDIPHAGGLAILFPNWMRYTLDTNVGRFKNLMLNMFDIDTEGKTDKEIALEGIDKLSA FWTSLGAPSRLADYNIGEEKLELIADIAAKEMEHGGFGNFQKLNKDDVLAILRASL*" /label="bdhK CDS" gene complement(2655759..2656931) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /label="bdhK gene" S_feature 2656094..2657015 /Source="Nicolas_S_feature" /locus_tag="new_3222530_3223451" /HighExp="S6, S7, S8, BT, S5, C30, LBGstat, B36, G135, G150" /AntisenseName="yugK" /AntisenseCor="4.31382473780575E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1197" promotor_-10 complement(2656964..2656983) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-10" upshifts complement(2656977) /Source="Nicolas_upshifts" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="upshifts" promotor_-35 complement(2657000..2657003) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-35" CDS complement(2657035..2658198) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 2673038, 9643546, 11466286, 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase" /protein_id="NP_391015.1" /db_xref="EnsemblGenomes-Gn:BSU31370" /db_xref="EnsemblGenomes-Tr:CAB15126" /db_xref="GOA:O05239" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12364" /db_xref="UniProtKB/Swiss-Prot:O05239" /translation="MQNFTYWNPTKLIFGRGEVERLPEELKPYGKNVLLVYGGGSIKR SGLYDQVIEQLNKAGATVHELAGVEPNPRVSTVNKGVAICKEQNIDFLLAVGGGSVID CTKAIAAGAKYDGDAWDIVTKKHQPKDALPFGTVLTLAATGSEMNSGSVITNWETKEK YGWGSPLVFPKFSILDPVNTFTVPKNHTIYGMVDMMSHVFEQYFHHVSNTPYQDRMCE SLLRTVIETAPKLINDLENYELRETILYTGTIALNGMLSMGARGDWATHNIEHAVSAV YDIPHAGGLAILFPNWMRHTLSENPARMKQLAVRVFDVEEAGKTDEEIALEGIDKLSA FWTSLGAPNRLADYDINDEQLDTIADKAMANGTFGQFKSLNKEDVLSILKASL*" /label="bdhJ CDS" gene complement(2657035..2658198) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /label="bdhJ gene" downshifts complement(2657050) /Source="Nicolas_upshifts" /id="D1626" /incds=0 /nref=167 /ntot=237 /MaxReadThrough="6.69366" /MaxDrop="4.74696" /score="28.8200012" /energy="-13.4" /TU="U2441" /idTUdmin="U2444" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2658213..2658232) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-10" upshifts complement(2658231) /Source="Nicolas_upshifts" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="upshifts" S_feature complement(2658233..2658388) /Source="Nicolas_S_feature" /locus_tag="new_3224669_3224824_c" /HighExp="S8, S7, S4, S5, S6, LoTm, Cold, LBGtran, G180, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25658199999999998" /TUshortSig="SigGF, SigA" /TUshortPSig="0.679, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1198" promotor_-35 complement(2658247..2658254) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-35" promotor_-35 2658284..2658290 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2658305..2658323 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2658315 /Source="Nicolas_upshifts" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2658316..2658374 /Source="Nicolas_S_feature" /locus_tag="new_3224752_3224810" /HighExp="Etha, Salt, Heat, M9-stat, LPhT, Sw, Gly, BC, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1199" promotor_-35 2658361..2658367 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2658363..2658374) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2658376 /Source="Nicolas_upshifts" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2658381..2658392 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2658388..2658394) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2658388) /Source="Nicolas_upshifts" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2658390..2658701) /Source="Nicolas_S_feature" /locus_tag="new_3224826_3225137_c" /HighExp="Cold, LBGtran, LoTm, G180, LBGexp, dia15, G135, H2O2, Paraq, Oxctl" /AntisenseName="yuzA" /AntisenseCor="-0.50065532030853999" /AntisenseRegPval="-17.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1200" CDS 2658428..2658664 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391016.1" /db_xref="EnsemblGenomes-Gn:BSU31380" /db_xref="EnsemblGenomes-Tr:CAB15127" /db_xref="GOA:O32087" /db_xref="InterPro:IPR007211" /db_xref="SubtiList:BG14050" /db_xref="UniProtKB/Swiss-Prot:O32087" /translation="MSTIQRICLVLTIIGAINWGLIGFFQFDLVAAIFGGQGSALSRI IYGLVGIAGLINLGLLFKPNEERSREEAANPEMR*" /label="yuzA CDS" gene 2658428..2658664 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /label="yuzA gene" downshifts 2658624 /Source="Nicolas_upshifts" /id="D1627" /incds=0 /nref=3 /ntot=45 /MaxReadThrough="7.39676" /MaxDrop="2.87922" /score="13.9936296" /energy="-12" /TU="U2442,U2443" /idTUdmin="U2442" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 2658690 /Source="Nicolas_upshifts" /id="D1628" /incds=0 /nref=25 /ntot=56 /MaxReadThrough="1.29261" /MaxDrop="7.50276" /score="13.9936296" /energy="-12" /TU="NA" /idTUdmin="U2442" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2658742..2659134) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 16014871, 19152054, 19636895; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; putative phosphorylase or nucleotidyl transferase; general stress protein" /protein_id="NP_391017.1" /db_xref="EnsemblGenomes-Gn:BSU31390" /db_xref="EnsemblGenomes-Tr:CAB15128" /db_xref="GOA:P80870" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="PDB:2K4K" /db_xref="SubtiList:BG12363" /db_xref="UniProtKB/Swiss-Prot:P80870" /translation="MAAKFEVGSVYTGKVTGLQAYGAFVALDEETQGLVHISEVTHGF VKDINEHLSVGDEVQVKVLAVDEEKGKISLSIRATQAAPEKKESKPRKPKAAQVSEEA STPQGFNTLKDKLEEWIEMSNRKDLIKK*" /label="yugI CDS" gene complement(2658742..2659134) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /label="yugI gene" downshifts complement(2658746) /Source="Nicolas_upshifts" /id="D1629" /incds=0 /nref=232 /ntot=268 /MaxReadThrough="5.9665" /MaxDrop="6.0195" /score="13.5952751" /energy="-15.6" /TU="U2445" /idTUdmin="U2448" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2659176..2659195) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-10" upshifts complement(2659183) /Source="Nicolas_upshifts" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="upshifts" S_feature complement(2659185..2659335) /Source="Nicolas_S_feature" /locus_tag="new_3225621_3225771_c" /HighExp="G180, C30, G135, LBGexp, G150, Oxctl, HPh, Cold, BMM, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1201" promotor_-35 complement(2659211..2659215) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-35" promotor_-35 2659238..2659244 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2659251..2660235 /Source="Nicolas_S_feature" /locus_tag="new_3225687_3226671" /HighExp="LoTm, C30, Salt, S7, S5, S8, Sw, S3, C90, S6" /AntisenseName="yugH" /AntisenseCor="-0.45629591209076698" /AntisenseRegPval="-14.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.662" /TUlongSig="NA" /TUlongPSig="NA" /label="S1202" upshifts 2659251 /Source="Nicolas_upshifts" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2659259..2659277 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2659336..2660496) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /EC_number="2.6.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_391018.2" /db_xref="EnsemblGenomes-Gn:BSU31400" /db_xref="EnsemblGenomes-Tr:CAB15129" /db_xref="GOA:Q795M6" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12362" /db_xref="UniProtKB/Swiss-Prot:Q795M6" /translation="MTSYLSDYVQQIKPSGIRKFFDLAATMEGVISLGVGEPDFVTAW NVREASILSLEQGYTSYTANAGLYSLREEISRYLSNRFDLSYSPDNELIVTVGASQAL DIAIRAIVNPGEEVIIPEPCFVAYDALVSLAGGIPVHVHTTADKGFKATAADFEAAVT EKTKAILICSPSNPTGSVYSKEELNEIAEFAKKHDVIVLADEIYAELTYDEEFTSIAA LPGMKERTVVISGFSKAFAMTGWRLGFAAAPSLLRDAMLKIHQYAMMCAPAMAQFAAL EGLKNGMEDVEKMKKSYRRRRNLFVESLNEIGLSCHHPGGAFYAFPSIKSMGMSSEQF AEELLTQEKVAVVPGSVFGPSGEGYIRCSYATSIEQLQEALVRMKRFLHKTT*" /label="yugH CDS" gene complement(2659336..2660496) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /label="yugH gene" promotor_-35 2660388..2660394 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2660406 /Source="Nicolas_upshifts" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2660408..2660412 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2660497..2660997) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_391019.1" /db_xref="EnsemblGenomes-Gn:BSU31410" /db_xref="EnsemblGenomes-Tr:CAB15130" /db_xref="GOA:O05236" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12361" /db_xref="UniProtKB/Swiss-Prot:O05236" /translation="MKLTEKETEILEILDENSRADLETIAKMAGIPVNEVKTIIDKLE KEKVIIDYSAMIDWRKVDGHEGVTAMIDVKVTPKRGVGFDEVAERIYRFQEVESVYLM SGVYDLSVVIRGNSMSDVARFVSDKLSTLDSVVSTTTHFILKKYKHDGKVFETGDDDK RIVVSP*" /label="yugG CDS" gene complement(2660497..2660997) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /label="yugG gene" promotor_-10 complement(2661027..2661046) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-10" promotor_-35 2661033..2661039 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2661048) /Source="Nicolas_upshifts" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="upshifts" promotor_-10 2661054..2661065 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2661054 /Source="Nicolas_upshifts" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2661057..2661064) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-35" S_feature 2661066..2661144 /Source="Nicolas_S_feature" /locus_tag="new_3227502_3227580" /HighExp="S8, S5, S6, S7, S4, C30, Glucon, Pyr, nit, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1203" CDS 2661145..2661966 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391020.1" /db_xref="EnsemblGenomes-Gn:BSU31420" /db_xref="EnsemblGenomes-Tr:CAB15131" /db_xref="GOA:O05235" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR013595" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12360" /db_xref="UniProtKB/Swiss-Prot:O05235" /translation="MEAVSPIRRFTVDGVNVYYEHYQNPGRQTLVCVHGFLSSAFSFR KVIPLLRDKYDIIALDLPPFGQSEKSRTFIYTYQNLAKLVIGILEHLQVKQAVLVGHS MGGQISLSAALQKPELFSKVVLLCSSGYLKRSHPTIIFGTHIPYFHLYIKRWLSKEGV MKNLLNVVHDKSLIDEEMIDGYGRPFQDEQIFKAMTRFIRHREGDLEPEQLKKMNKPA LLIWGEEDRIVPMEIGKRLHADLPNSVLYSLGQTGHLVPEERPELISEHIADFIK*" /label="yugF CDS" gene 2661145..2661966 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /label="yugF gene" downshifts 2661946 /Source="Nicolas_upshifts" /id="D1630" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="1.0929" /MaxDrop="3.08755" /score="11.2614618" /energy="-6.6" /TU="NA" /idTUdmin="U2449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2661993) /Source="Nicolas_upshifts" /id="D1631" /incds=0 /nref=20 /ntot=156 /MaxReadThrough="2.22671" /MaxDrop="4.10906" /score="25.9859375" /energy="-6.6" /TU="NA" /idTUdmin="U2451" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(2661995..2662255) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391021.2" /db_xref="EnsemblGenomes-Gn:BSU31430" /db_xref="EnsemblGenomes-Tr:CAB15132" /db_xref="InterPro:IPR015053" /db_xref="InterPro:IPR023162" /db_xref="SubtiList:BG12359" /db_xref="UniProtKB/Swiss-Prot:O05234" /translation="MEESHAVREMIKIIAKWDPFKYGEEFYETEAVDVVQAVYDENDP DLLAKSIQQIFETSFEQTLPIASCREVAGQLLFIKNSSSCTP*" /label="yugE CDS" gene complement(2661995..2662255) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /label="yugE gene" promotor_-35 2662245..2662248 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-35" promotor_-10 2662263..2662282 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-10" upshifts 2662275 /Source="Nicolas_upshifts" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="upshifts" S_feature 2662276..2662341 /Source="Nicolas_S_feature" /locus_tag="new_3228712_3228777" /HighExp="dia15, dia5, Lbexp, dia0, LBGtran, G180, Diami, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1204" promotor_-10 complement(2662281..2662300) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2662286) /Source="Nicolas_upshifts" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2662312..2662318) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2662342..2663505 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /EC_number="4.4.1.1" /EC_number="4.4.1.13" /EC_number="4.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15760717, 26337367, 28895253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15760717, 26337367, 28895253; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous cystathionine / cystine beta-lyase /cysteine desulfhydrase" /protein_id="NP_391022.1" /db_xref="EnsemblGenomes-Gn:BSU31440" /db_xref="EnsemblGenomes-Tr:CAB15133" /db_xref="GOA:Q08432" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR027619" /db_xref="SubtiList:BG10744" /db_xref="UniProtKB/Swiss-Prot:Q08432" /translation="MNFDKREERLGTQSVKWDKTGELFGVTDALPMWVADMDFRAPEA ITEALKERLDHGIFGYTTPDQKTKDAVCGWMQNRHGWKVNPESITFSPGVVTALSMAV QAFTEPGDQVVVQPPVYTPFYHMVEKNGRHILHNPLLEKDGAYAIDFEDLETKLSDPS VTLFILCNPHNPSGRSWSREDLLKLGELCLEHGVTVVSDEIHSDLMLYGHKHTPFASL SDDFADISVTCAAPSKTFNIAGLQASAIIIPDRLKRAKFSASLQRNGLGGLNAFAVTA IEAAYSKGGPWLDELITYIEKNMNEAEAFLSTELPKVKMMKPDASYLIWLDFSAYGLS DAELQQRMLKKGKVILEPGTKYGPGGEGFMRLNAGCSLATLQDGLRRIKAALS*" /label="patB CDS" gene 2662342..2663505 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /label="patB gene" promotor_-35 2663568..2663574 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2663586..2663605 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2663596 /Source="Nicolas_upshifts" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2663631..2664917 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9426145, 11069677, 15849754, 16850406, 26152584, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 11069677, 15849754, 16850406, 26152584, 28583948; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-binding histidinekinase" /protein_id="NP_391023.2" /db_xref="EnsemblGenomes-Gn:BSU31450" /db_xref="EnsemblGenomes-Tr:CAB15134" /db_xref="GOA:Q08430" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10745" /db_xref="UniProtKB/Swiss-Prot:Q08430" /translation="MEILKDYLLHICFILFPILLYQVFWLGKPAILVPKINSGLVTLF ACGASVLCIIFPIHEMDYIQYGLQMIPVIICLFYISTASGLTVAASVLCFELLFYEPS AMFVFTLLPFLIIIPILFQKKWPFMSKAKKLLLSLLISCVEIFLFFASSWILSALNIL NFQKSGIFVYEAAVSGLFRSSVLLLSIYIIESIAENIALRSQLIHSEKMTIVSELAAS VAHEVRNPLTVVRGFVQLLFNDETLQNKSSADYKKLVLSELDRAQGIITNYLDMAKQQ LYEKEVFDLSALIKETSSLMVSYANYKSVTVEAETEPDLLIYGDATKLKQAVINLMKN SIEAVPHGKGMIHISAKRNGHTIMINITDNGVGMTDHQMQKLGEPYYSLKTNGTGLGL TVTFSIIEHHHGTISFNSSFQKGTTVTIKLPADLPH*" /label="kinB CDS" gene 2663631..2664917 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /label="kinB gene" S_feature complement(2664633..2665375) /Source="Nicolas_S_feature" /locus_tag="new_3231069_3231811_c" /HighExp="BT, S8, B36, S6, S7, S5, S3, S4, Cold, Pyr" /AntisenseName="kapB" /AntisenseCor="-0.71681066342113797" /AntisenseRegPval="-43" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigK" /TUshortPSig="0.709, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1205" promotor_-35 2664912..2664919 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2664933..2664952 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2664934 /Source="Nicolas_upshifts" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2664963..2665349 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9426145, 23335417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 23335417; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for KinB signal transduction andactivation of the phosphorelay to sporulation" /protein_id="NP_391024.1" /db_xref="EnsemblGenomes-Gn:BSU31460" /db_xref="EnsemblGenomes-Tr:CAB15135" /db_xref="GOA:Q08429" /db_xref="InterPro:IPR014916" /db_xref="SubtiList:BG10746" /db_xref="UniProtKB/Swiss-Prot:Q08429" /translation="MSTFETGSIVKGFYKTGVYIGEITACRPQHYLVKVKAVLTHPAQ GDLHHPKQADVPFFHERKALAYGEQTNIPHHMVKPYDGEVPDYTESLREATAQMRAKL NEDGSEWAKRSLHNLDILEKEYFNRP*" /label="kapB CDS" gene 2664963..2665349 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /label="kapB gene" downshifts 2665331 /Source="Nicolas_upshifts" /id="D1632" /incds=0 /nref=209 /ntot=249 /MaxReadThrough="1.62013" /MaxDrop="5.57132" /score="1.97959632" /energy="-9.2" /TU="NA" /idTUdmin="U2452" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2665376..2665993) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27188294; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exoribonuclease (3'-5')" /protein_id="NP_391025.1" /db_xref="EnsemblGenomes-Gn:BSU31470" /db_xref="EnsemblGenomes-Tr:CAB15136" /db_xref="GOA:O05231" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12358" /db_xref="UniProtKB/Swiss-Prot:O05231" /translation="MTTNSLLIIDFEFTMPDGKYSPQNFFPEIIEAGIVKSIDDEVVE TFSSYVRPKKFPKLTKRCKSFLKITQKQVDEGMRFEDFIRKLNELDPEKNSTIITWGN MDMKVLKQNCMFNHIPFPFKGEMRDLSLEYKNFFGDRTLTGLWKAAEEYGDSGTGTHH KALDDALTAYKLFKLVEQDKQYLEKPKPPTIGERIDLTELLKRAT*" /label="kapD CDS" gene complement(2665376..2665993) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /label="kapD gene" promotor_-10 complement(2666028..2666046) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2666045) /Source="Nicolas_upshifts" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2666047..2668135) /Source="Nicolas_S_feature" /locus_tag="new_3232483_3234571_c" /HighExp="S8, BT, B36, S7, S6, Pyr, C30, B60, S5, G135" /AntisenseName="yuxJ" /AntisenseCor="-0.168930816447634" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1206" promotor_-35 complement(2666061..2666066) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2666109..2666112 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-35" promotor_-10 2666127..2666146 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-10" upshifts 2666138 /Source="Nicolas_upshifts" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="upshifts" CDS 2666204..2667382 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter induced in acid stress" /protein_id="NP_391026.2" /db_xref="EnsemblGenomes-Gn:BSU31480" /db_xref="EnsemblGenomes-Tr:CAB15137" /db_xref="GOA:P40760" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10976" /db_xref="UniProtKB/Swiss-Prot:P40760" /translation="MWLANFFVSASTTMIVPFLSLYIETLSSFSNGFVQRWSGYVFGI TFLMAFLVSPFWGRFGDKRGYKKILMATGTGIALSIFFMGFVTSVYQLFFLRMAMGLV TGFIPTSLAMISAQTPKSSAGKTLGTLQMGQVSGSLFGPLLGGMLADRFGFTYTFFIT SFVIFSSVLLVLFGVKEKHLAEKTAKRTSYSRKEVLSYIFHHPALWVMMLLTMLIQTG NFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLARKWGDLGDRYGHRRILIG LLLAASFFFIPQALASSLSVLLVFRFLFGMAMGGLLPCITAAIRVQAPGSIQGEVLGY NVSFRFLGNVLGPLLGGIISSHFTISATFYVTAFLFFAGACMLWIMQKLRKDSYAKAS *" /label="yuxJ CDS" gene 2666204..2667382 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /label="yuxJ gene" promotor_-35 2667420..2667426 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2667438..2667457 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2667443 /Source="Nicolas_upshifts" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="upshifts" CDS 2667475..2669349 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /EC_number="2.-.-.-" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7961491, 9274030; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4" /protein_id="NP_391027.2" /db_xref="EnsemblGenomes-Gn:BSU31490" /db_xref="EnsemblGenomes-Tr:CAB15138" /db_xref="GOA:P40750" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10977" /db_xref="UniProtKB/Swiss-Prot:P40750" /translation="MTMLRKIIGWILLLCIIPLFAFTVIASGKEVKQMKSLDQVLDKN IDLKDISLVQNSYMYDRDGSLVSEIVSDHENRVLVPFNKIPEEVKQIFLTSEDRHFYE HKGFDFMGMVRATASNVKDKKIDQGASTITQQLSRNLYLSHERSFSRKLTELAYSYQL EKKYTKNEILEAYLNTIYFNNGVYGVGSAAQFYFSKPLKSLTVGEMAFICAIPNNPTL YDPLKHFDYTKSRQERLLKGLKDAGVITDKELKKAVKQKIKLDVEKREDKYPDYVSYV NDEFTQLVSESEGFDKRLQKASGKQKEKIENELSARVSTLMKDGVKIYTALDPYMQNQ VVAQMNSKLPYADVQGGAAVINHQTHQIIALSGGKNYQKYDFNRAYQAYRQPGSSIKP LLDYGPYIEQTGATTSSTIDASKFCSKDYCPQNYNNRTYGTVTLDTAFKNSYNTPAIR MLDRVGIQKAFSYIEPYHFAKLVDSDYLLPAALGGFTNGMTPLEMTKAYTTFGNSGSY TPSHAITKVTDLKGKTLYKWNDKATQIFSVRTNMQLKKLMSSVVKSGTGKKAYFNAPY IGGKTGTSNDYHDMWFVGLTDTYTMGVWVGKDTPTSVEYLHSISPQLSIWKGTLQAAY *" /label="pbpD CDS" gene 2667475..2669349 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /label="pbpD gene" promotor_-10 complement(2668115..2668134) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2668135) /Source="Nicolas_upshifts" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2668148..2668157) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2669370..2669783 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26335199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase" /protein_id="NP_391028.1" /db_xref="EnsemblGenomes-Gn:BSU31500" /db_xref="EnsemblGenomes-Tr:CAB15139" /db_xref="InterPro:IPR007263" /db_xref="SubtiList:BG10978" /db_xref="UniProtKB/Swiss-Prot:P40761" /translation="MTSEQIPNRVLLFDGVCNLCNGAVQFIIKRDPDGLISFTSLQSE TGQSLLKKSGLPTDRFDSFVFIEDGQVYTKSTAAIKVFRHLRGPWRLFVLFFAVPKPV RDMVYSFIAKNRYKWFGKKNECMLPSPSIKKRFLP*" /label="yuxK CDS" gene 2669370..2669783 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /label="yuxK gene" downshifts 2669775 /Source="Nicolas_upshifts" /id="D1633" /incds=0 /nref=1 /ntot=254 /MaxReadThrough="5.05064" /MaxDrop="3.14634" /score="-3.58105315" /energy="-11.5" /TU="U2456" /idTUdmin="U2456" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2669986..2670543) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391029.2" /db_xref="EnsemblGenomes-Gn:BSU31510" /db_xref="EnsemblGenomes-Tr:CAB15140" /db_xref="GOA:O05249" /db_xref="InterPro:IPR035289" /db_xref="SubtiList:BG12346" /db_xref="UniProtKB/Swiss-Prot:O05249" /translation="MKNTYLTGYFPLIAILLFSSSLSISTSLYALKMLSSFGMYDGML DYFSEKGIRLALFAAFALLYFMVLSALKLIANTVTELSLLFFANDPEGNNLKKLRMGS MIYLGGGILSFVLLQNVIWIVIWFAVVTLAYFVFTVYRIYSTLSLMSLVGFILLELLF WFTFVIGILFIFIKLYNSIMASLPV*" /label="yufK CDS" gene complement(2669986..2670543) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /label="yufK gene" misc_feature 2670007..2670026 /Source="Nicolas_upshift_promotors" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2670017 /Source="Nicolas_upshifts" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2670027) /Source="Nicolas_upshifts" /id="D1634" /incds=0 /nref=10 /ntot=201 /MaxReadThrough="3.90201" /MaxDrop="3.94501" /score="-6.00543052" /energy="-18.5" /TU="U2459" /idTUdmin="U2459" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 2670039..2670720 /Source="Nicolas_S_feature" /locus_tag="new_3236475_3237156" /HighExp="Diami, Cold, LBGstat, H2O2, Lbtran, Gly, M0t90, GM 10, GM-0.2, dia15" /AntisenseName="yufK" /AntisenseCor="0.32488342936044701" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.878" /TUlongSig="NA" /TUlongPSig="NA" /label="S1207" promotor_-10 complement(2670569..2670588) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2670577) /Source="Nicolas_upshifts" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2670604..2670608) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2670721..2672322 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [MaeM]" /protein_id="NP_391030.1" /db_xref="EnsemblGenomes-Gn:BSU31520" /db_xref="EnsemblGenomes-Tr:CAB15141" /db_xref="GOA:O05250" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12347" /db_xref="UniProtKB/Swiss-Prot:O05250" /translation="MKKTLKLQTRLTIFVCIVVLIALLITFFTVGAQTTKRIRDQEKA TALQTAEMVAEAPMTAAALESGKKQKELQSYTKRVQKITGTEFVVVMDMNGIRKTHPD PSKIGKKFRGGDESEVLKGHVHISTASGTLGKSQRAFVPVYAENGKQVGAVAVGITVN EIDEVISHSLRPLYFIICVSIFVGVIGAVIVARTVKNIMYGLEPYEIATLLEERSAML ESTKEGILAVDEHGKIKLANAEAKRLFVKMGINTNPIDQDVDDILPKSRLKKVIETKK PLQDRDVRINGLELVFNEVPIQLKGQTVGAIATFRDKTEVKHLAEQLSGVKMYANALR AQSHEFMNKLHVILGLVQLKEYDDLGDYIKDIAIQQKSETSEIINDVKSSVLAGFLLG KQSFIREQGANLDIECNGVIPNAADPSVIHELITIIGNLINNGLDAVADMPKKQITMS MRFHNSILDIEITDTGAGMSEEDQAKVFEQGYSTKGKNRGFGLYFTQQSIENLKGQMI LTSEKNEGTTFSIRIPYEPKEENHD*" /label="maeL CDS" gene 2670721..2672322 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /label="maeL gene" CDS 2672315..2673022 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator for malate metabolism [MaeL]" /protein_id="NP_391031.1" /db_xref="EnsemblGenomes-Gn:BSU31530" /db_xref="EnsemblGenomes-Tr:CAB15142" /db_xref="GOA:O05251" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12348" /db_xref="UniProtKB/Swiss-Prot:O05251" /translation="MINVLIVEDDPMVGELNKRYLSQIDGFQLKGIASSFQSALHILG EHHIDLILLDIYMPGKNGLELLTELRAQNEAVDVIVISAASELDVIKKTLRYGAVDYL IKPFEFERFQTALSDYRRKQKVYSTHRNMSQKELDAELFQKKEATEKVQLPKGLTKST LKLIWSSIQSFENESFTTEDLAKHTEISQVSIRKYLKFLEDIQVLNVEMAYGTIGRPV FQYNVNNSNINGIKQYL*" /label="maeM CDS" gene 2672315..2673022 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /label="maeM gene" downshifts 2673007 /Source="Nicolas_upshifts" /id="D1635" /incds=0 /nref=173 /ntot=245 /MaxReadThrough="1.97489" /MaxDrop="5.86018" /score="19.9464971" /energy="-15.3" /TU="NA" /idTUdmin="U2458" /TUdmin=2660 /isTUend="FALSE" /label="downshifts" promotor_-35 2673186..2673193 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2673204..2673493 /Source="Nicolas_S_feature" /locus_tag="new_3239640_3239929" /HighExp="T1.30H, T1.0H, T2.30H, T2.0H, M9-stat, S1, T3.0H, T3.30H, T0.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1208" upshifts 2673204 /Source="Nicolas_upshifts" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2673208..2673227 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2673494..2674573 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in guanosine transport" /protein_id="NP_391032.2" /db_xref="EnsemblGenomes-Gn:BSU31540" /db_xref="EnsemblGenomes-Tr:CAB15143" /db_xref="GOA:O05252" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12349" /db_xref="UniProtKB/Swiss-Prot:O05252" /translation="MNKRKIGLAMSLVIAAGTILGACGNSEKSSGSGEGKNKFSVAMV TDVGGVDDKSFNQSAWEGIQAFGKENGLKKGKNGYDYLQSKSDADYTTNLNKLARENF DLIYGVGYLMEDSISEIADQRKNTNFAIIDAVVDKDNVASITFKEQEGSFLVGVAAAL SSKSGKIGFVGGMESELIKKFEVGFRAGVQAVNPKAVVEVKYAGGFDKADVGKATAES MYKSGVDVIYHSAGATGTGVFTEAKNLKKEDPKRDVWVIGVDKDQYAEGQVEGTDDNV TLTSMVKKVDTVVEDVTKKASDGKFPGGETLTYGLDQDGVGISPSKQNLSDDVIKAVD KWKKKIIDGLEIPATEKELKTFKAE*" /label="nupN CDS" gene 2673494..2674573 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /label="nupN gene" CDS 2674649..2676181 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanosine ABC transporter (ATP-binding protein)" /protein_id="NP_391033.1" /db_xref="EnsemblGenomes-Gn:BSU31550" /db_xref="EnsemblGenomes-Tr:CAB15144" /db_xref="GOA:O05253" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12350" /db_xref="UniProtKB/Swiss-Prot:O05253" /translation="MEYVIEMLNIRKAFPGIVANDNINLQVKKGEIHALLGENGAGKS TLMNVLFGLYQPERGEIRVRGEKVHINSPNKANDLGIGMVHQHFMLVDTFTVAENIIL GKEPKKFGRIDRKRAGQEVQDISDRYGLQIHPEAKAADISVGMQQRAEILKTLYRGAD ILIFDEPTAVLTPHEIKELMQIMKNLVKEGKSIILITHKLKEIMEICDRVTVIRKGKG IKTLDVRDTNQDELASLMVGREVSFKTEKRAAQPGAEVLAIDGITVKDTRGIETVRDL SLSVKAGEIVGIAGVDGNGQSELIEAVTGLRKTDSGTITLNGKQIQNLTPRKITESGI GHIPQDRHKHGLVLDFPIGENILLQSYYKKPYSALGVLHKGEMYKKARSLITEYDVRT PDEYTHARALSGGNQQKAIIGREIDRNPDLLIAAQPTRGLDVGAIEFVHKKLIEQRDA GKAVLLLSFELEEIMNLSDRIAVIFEGRIIASVNPQETTEQELGLLMAGSTQKEAGKA NG*" /label="nupO CDS" gene 2674649..2676181 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /label="nupO gene" CDS 2676174..2677220 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391034.1" /db_xref="EnsemblGenomes-Gn:BSU31560" /db_xref="EnsemblGenomes-Tr:CAB15145" /db_xref="GOA:O05254" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR002229" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12351" /db_xref="UniProtKB/Swiss-Prot:O05254" /translation="MVKRLSHLLVPLIAIILGLAAGALIMLVSGYSVASGYSALWNGI FGEIYYVGETIRQITPYILSGLAVAFAFRTGLFNIGVEGQLLVGWTAAVWVGTAFDGP AYIHLPLALITAAAAGGLWGFIPGILKARFYVHEVIVTIMMNYIALHMTNYIISNVLT DHQDKTGKIHESASLRSPFLEQITDYSRLHLGIIVALLAAVIMWFIINKSTKGFELRA VGFNQHASQYAGMSVRKNIMTSMLISGAFAGLAGAMEGLGTFEYAAVKGAFTGVGFDG IAVALLGGNTAVGVVLAACLLGGLKIGALNMPIESGVPSEVVDIVIAIIILFVASSYA IRFVMGKLKKKGAN*" /label="nupP CDS" gene 2676174..2677220 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /label="nupP gene" CDS 2677221..2678180 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391035.1" /db_xref="EnsemblGenomes-Gn:BSU31570" /db_xref="EnsemblGenomes-Tr:CAB15146" /db_xref="GOA:O05255" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12352" /db_xref="UniProtKB/Swiss-Prot:O05255" /translation="MDIVQILSIIVPATLVYAAPLILTALGGVFSERSGVVNIGLEGL MIIGAFTSVLFNLFFGQELGAAAPWLSLLAAMAAGALFSLIHAAAAISFRADQTVSGV AINMLALGATLFIVKLIYGKAQTDKIPEPFYKTKIPGLGDIPVLGKIFFSDVYYTSIL AIALAFISWFILFKTPFGLRIRSVGEHPMAADTMGINVYKMRYIGVMISGLFGGLGGG VYASTIALDFTHSTISGQGFIALAALVFGKWHPIGALGAALFFGFAQSLSIIGSLLPL FKDIPNVYMLMAPYILTILALTGFIGRADAPKANGVPYIKGKR*" /label="nupQ CDS" gene 2677221..2678180 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /label="nupQ gene" S_feature 2678181..2678302 /Source="Nicolas_S_feature" /locus_tag="new_3244617_3244738" /HighExp="S1, BT, M9-stat, T1.30H, S2, LoTm, T1.0H, T2.30H, T2.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1209" promotor_-35 2678275..2678278 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2678293..2678312 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2678304 /Source="Nicolas_upshifts" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="upshifts" CDS 2678334..2679680 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/malate symporter" /protein_id="NP_391036.1" /db_xref="EnsemblGenomes-Gn:BSU31580" /db_xref="EnsemblGenomes-Tr:CAB15147" /db_xref="GOA:O05256" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12353" /db_xref="UniProtKB/Swiss-Prot:O05256" /translation="MGAIPKTGTISPEQKDSQEKNLFQKIWSWEIGVIPLPLYTVLAV IIILAAYYNELPANMLGGFAIIMILGVFLGDIGQRIPILKDIGGPAILSLFVPSFLVF YNVLNSTSLDAVTNLMKTSNFLYFYIACLVVGSILGMNRIVLIQGFIRMFVPLVAGTI AAVAAGILVGFIFGYSAYDSFFFVVVPIIAGGIGEGILPLSIAYSQILGSSADVFVSQ LVPAAIIGNVFAIICAALMKKLGDKRPDLNGNGRLVKSKKANEIFNQKEAEAKIDFKL MGAGVLLACTFFIFGGLLEKFIFIPGAILMIISAAAVKYANILPKKMEEGAYQLYKFI SSSFTWPLMVGLGILFIPLDDVASVISIPFVIICISVVIAMIGSGYFVGKLMNMYPVE SAIVTCCHSGLGGTGDVAILSASGRMGLMPFAQISTRLGGAGTVICATVLLRFFTS*" /label="maeN CDS" gene 2678334..2679680 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /label="maeN gene" downshifts 2679663 /Source="Nicolas_upshifts" /id="D1636" /incds=0 /nref=68 /ntot=109 /MaxReadThrough="0.286069999999999" /MaxDrop="6.51197" /score="36.240717" /energy="-12.2" /TU="NA" /idTUdmin="U2461" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(2679716..2679931) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391037.1" /db_xref="EnsemblGenomes-Gn:BSU31590" /db_xref="EnsemblGenomes-Tr:CAB15148" /db_xref="GOA:O05257" /db_xref="SubtiList:BG12354" /db_xref="UniProtKB/Swiss-Prot:O05257" /translation="MKTKVVMCSGLFCSVFAGAFMLNQYDGRSGVAACDEWELYLLEH HLSARMSETESKDLPFGPREYIRIVNK*" /label="yufS CDS" gene complement(2679716..2679931) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /label="yufS gene" promotor_-35 2679871..2679877 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2679891..2679902 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2679895 /Source="Nicolas_upshifts" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2679942..2679960) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2679949) /Source="Nicolas_upshifts" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2679974..2679981 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2679976..2679981) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2679996..2680091 /Source="Nicolas_S_feature" /locus_tag="new_3246432_3246527" /HighExp="G180, Diami, G150, Oxctl, G135, H2O2, Paraq, MG 60, MG 15, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1210" promotor_-10 2679996..2680015 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2679996 /Source="Nicolas_upshifts" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2680054..2680058 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2680074..2680093 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2680093..2680242 /Source="Nicolas_S_feature" /locus_tag="new_3246529_3246678" /HighExp="G135, G180, Diami, G150, H2O2, Oxctl, LBGexp, Paraq, Salt, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1211" upshifts 2680093 /Source="Nicolas_upshifts" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2680162..2682567 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium transporter component of a Na+/H+ antiporter" /protein_id="NP_391038.2" /db_xref="EnsemblGenomes-Gn:BSU31600" /db_xref="EnsemblGenomes-Tr:CAB15149" /db_xref="GOA:Q9K2S2" /db_xref="InterPro:IPR001516" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR005663" /db_xref="InterPro:IPR018393" /db_xref="InterPro:IPR025383" /db_xref="SubtiList:BG12355" /db_xref="UniProtKB/Swiss-Prot:Q9K2S2" /translation="MQLLHLAILSPFLFAFIIPFLAKYAKRVHTGWFVLILPVLLFIY FLPMIRMTQSGETLRSVLEWIPSLGINFTVYIDGLGLLFALLITGIGSLVTLYSIFYL SKEKEQLGPFYVYLLMFMGAMLGVVLVDNVMVLYMFWELTSLSSFLLIGYWYKREKSR YGAAKSLLITVSGGLCMLGGFILLYLITDSFSIREMVHQVQLIAGHELFIPAMILILL GAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGIYVIARFSPIFAFSAQWFWI VSLVGLFTMVWGSFHAVKQTDLKSILAFSTVSQLGMIISMLGVSAAALHYGHTEYYTV AAMAAIFHLINHATFKGSLFMAVGIIDHETGTRDIRKLGGLMAIMPITFTISLIGTFS MAGLPPFNGFLSKEMFFTSMLRVTHFDLFNVQTWGVLFPLFAWIGSVFTFIYSMKLLF KTFRGNYQPEQLEKQAHEAPVGMLVPPVILVALAVSLFFFPNILSYSLIEPAMNSIYP TLLDGHEKFHVHISQWHGVTTELLMTAGIVVIGTIGYLSLNKWKGIYKLFPSKLTLNR LYDKLLTMMEKGSYRVTKQYMTGFLRDYLLYIFAGFIILIGGAFAIKGGFSFKTEGMA KIGVYEIILTLVMISATVATVFARSRLTAIIALGVVGYTLALFFVIFRAPDLALTQLV IETISVALFLLCFYHLPKLRLKTKTRTFRMTNFIISLGVGVIVTLLGIASSSQRTKDS IASFFVKHSHDLGGGDNVVNVILVDFRGFDTMFEITVLTIAALGIYSMIKTKVKEEGK SGE*" /label="mrpA CDS" gene 2680162..2682567 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /label="mrpA gene" CDS 2682560..2682991 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter complex" /protein_id="NP_391039.1" /db_xref="EnsemblGenomes-Gn:BSU31610" /db_xref="EnsemblGenomes-Tr:CAB15150" /db_xref="GOA:O05259" /db_xref="InterPro:IPR005281" /db_xref="InterPro:IPR007182" /db_xref="SubtiList:BG12356" /db_xref="UniProtKB/Swiss-Prot:O05259" /translation="MNEQKTNDLILQTATKLVSFIILLFSFYLFLSGHNAPGGGFVGG LITSSSIVLLLLAYDLKTVRSLLPVNFIYVAGAGLLLAVLTGVGSFVFGAPFLTHTFG YFQLPILGKTELATATIFDLGVYLVVVGITMTIIQTIGEEE*" /label="mrpB CDS" gene 2682560..2682991 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /label="mrpB gene" CDS 2682991..2683332 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of Na+/H+ antiporter" /protein_id="NP_391040.2" /db_xref="EnsemblGenomes-Gn:BSU31620" /db_xref="EnsemblGenomes-Tr:CAB15151" /db_xref="GOA:O05260" /db_xref="SubtiList:BG12357" /db_xref="UniProtKB/Swiss-Prot:O05260" /translation="MEILMAVLAGIIFMAATYLLLSKSLLRVIIGTALLSHGVHLMLL TMGGLKKGAAPILSEHAKSFVDPLPQALILTAIVISFGVTSFILVMAFRAYQELKSDD MDQMRGNDQHE*" /label="mrpC CDS" gene 2682991..2683332 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /label="mrpC gene" promotor_no_box 2683223..2683323 /Source="Nicolas_upshift_promotors" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2683283 /Source="Nicolas_upshifts" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2683325..2684806 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton transporter component of Na+/H+ antiporter" /protein_id="NP_391041.3" /db_xref="EnsemblGenomes-Gn:BSU31630" /db_xref="EnsemblGenomes-Tr:CAB15152" /db_xref="GOA:O05229" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR003918" /db_xref="InterPro:IPR004775" /db_xref="SubtiList:BG12345" /db_xref="UniProtKB/Swiss-Prot:O05229" /translation="MNNFVILPILIPLLSAILLIFMTKNLMLMRIFSTAASAIGIVIS GILVQTVFTKGIQTLSLGGWKAPYGIVLAADQFASLLVLTTAIIGLLVGLYSFRSVGE KRERSFYYSGVQFLLAGVSGAFLTGDLFNMYVFFELLLIASYMLIVLGGTKIQLRESL KYIVFNIVSSALFVIGVGFLYAVTGTLNMADLSVKISESGQTGLITVIGVLLLLVFGM KGGIFPLYFWLPGSYYAPPAAISALFGALLTKVGLYAITRVFTLIFIHDTAFTHQLMI WLAALTVIFGVIGSLAYSNVMKIVIYNIITAVGVILFGVAVHTPASIQGAIYYLIHDM LIKGALFMLAGTLIALTGTASLHKMGGLIKRYPVLGWMFFISAISLAGIPPLSGFVGK FKIAEGGFAEGEFTISMLILLSSLLVLYSVLRIFIHAFWGEEKETPKPNHRTAKGLLY PAAIFLLLSLLFGLGTEWVSPYVDQAAETLLNPEKYIEAVLKE*" /label="mrpD CDS" gene 2683325..2684806 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /label="mrpD gene" S_feature complement(2684058..2685926) /Source="Nicolas_S_feature" /locus_tag="new_3250494_3252362_c" /HighExp="S2, Lbstat, T5.0H, T3.30H, S3, T4.0H, T3.0H, T2.30H, S1, T2.0H" /AntisenseName="mrpD" /AntisenseCor="-0.59706140653928796" /AntisenseRegPval="-26.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1212" CDS 2684812..2685288 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 15849754, 16233411, 16850406, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 15849754, 16233411, 16850406, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="YP_054591.2" /db_xref="EnsemblGenomes-Gn:BSU31640" /db_xref="EnsemblGenomes-Tr:CAE01465" /db_xref="GOA:Q7WY60" /db_xref="InterPro:IPR002758" /db_xref="SubtiList:BG14181" /db_xref="UniProtKB/Swiss-Prot:Q7WY60" /translation="MAFQILLNVFLAFCWMFLSNSPSAAGFITGYILGMLSLFFFRRF FTRQFYLWKLISIIKLCFIFIKELYLANVSVMKSVLSPKLNIRPGIFAFKTELTKDWE ITMLSLLITLTPGTLVMDISDDRTILYIHAMDIEDAEKAIFDIRESFEKAIQEVSR*" /label="mrpE CDS" gene 2684812..2685288 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /label="mrpE gene" CDS 2685288..2685572 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 11356194, 12682299, 15019740, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 11356194, 12682299, 15019740, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter for Na+ and cholate" /protein_id="NP_391043.2" /db_xref="EnsemblGenomes-Gn:BSU31650" /db_xref="EnsemblGenomes-Tr:CAB15153" /db_xref="GOA:O05228" /db_xref="InterPro:IPR007208" /db_xref="SubtiList:BG12344" /db_xref="UniProtKB/Swiss-Prot:O05228" /translation="MFTLILQIALGIMAVSTFLYVIRVIKGPTVPDRVVALDAIGINL IAITALVSILLKTSAFLDIILLLGILSFIGTIAFSKFLEKGEIIENDRNR*" /label="mrpF CDS" gene 2685288..2685572 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /label="mrpF gene" CDS 2685556..2685930 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 15019740, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 15019740, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="NP_391044.1" /db_xref="EnsemblGenomes-Gn:BSU31660" /db_xref="EnsemblGenomes-Tr:CAB15154" /db_xref="GOA:O05227" /db_xref="InterPro:IPR005133" /db_xref="SubtiList:BG12343" /db_xref="UniProtKB/Swiss-Prot:O05227" /translation="MIETAKVVVAVFILLGALICLIASFGVLRLPDVFTRAHAASKGS TLGVNMILLGVFFYLWFVTGELSAKILLGILFIFITSPIGGHLICRAAYNSGVKLDER SVQDDYNGIRNFVIKRKEDSYL*" /label="mrpG CDS" gene 2685556..2685930 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /label="mrpG gene" downshifts 2685901 /Source="Nicolas_upshifts" /id="D1637" /incds=0 /nref=86 /ntot=185 /MaxReadThrough="1.46493" /MaxDrop="6.023" /score="32.1865197" /energy="-12.7" /TU="NA" /idTUdmin="U2464" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2685969..2686349) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /EC_number="3.1.-.-" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25010423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proofreading thioesterase in bacillibactin biosynthesis" /protein_id="NP_391045.2" /db_xref="EnsemblGenomes-Gn:BSU31670" /db_xref="EnsemblGenomes-Tr:CAB15155" /db_xref="GOA:P14205" /db_xref="InterPro:IPR003736" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10382" /db_xref="UniProtKB/Swiss-Prot:P14205" /translation="MDMKHTLLEALGIEIVENTAERCVAVMPVDHRTVQPFGYLHGGA SVALAETAASAGAQNLIDHTTQACVGLEINANHLKSVKEGTVKAIAEPVHIGRTTIVY HIHIYDEQERLICISRCTLAVIKK*" /label="yuxO CDS" gene complement(2685969..2686349) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /label="yuxO gene" downshifts complement(2685971) /Source="Nicolas_upshifts" /id="D1638" /incds=0 /nref=41 /ntot=206 /MaxReadThrough="4.53972" /MaxDrop="3.98532" /score="-4.4938943" /energy="-12.7" /TU="U2469" /idTUdmin="U2469" /TUdmin="-1050" /isTUend="FALSE" /label="downshifts" CDS complement(2686368..2687012) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response quorum-sensing regulator" /protein_id="NP_391046.1" /db_xref="EnsemblGenomes-Gn:BSU31680" /db_xref="EnsemblGenomes-Tr:CAB15156" /db_xref="GOA:P14204" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2KRF" /db_xref="PDB:3ULQ" /db_xref="SubtiList:BG10381" /db_xref="UniProtKB/Swiss-Prot:P14204" /translation="MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQH DFSSYDLILMDLNLGGEVNGMELSKQILQENPHCKIIVYTGYEVEDYFEEAIRAGLHG AISKTESKEKITQYIYHVLNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECL ILQEVEKGFTNQEIADALHLSKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL*" /label="comA CDS" gene complement(2686368..2687012) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /label="comA gene" S_feature complement(2687013..2687092) /Source="Nicolas_S_feature" /locus_tag="new_3253449_3253528_c" /HighExp="S2, Lbstat, M0t90, M40t90, MG 5, S1, ferm, T1.30H, nit, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1213" CDS complement(2687093..2689402) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /EC_number="2.7.-.-" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7698645, 7855425, 10419951, 14679219, 15066026, 16091050, 16787201, 20208433, 24130811; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_391047.2" /db_xref="EnsemblGenomes-Gn:BSU31690" /db_xref="EnsemblGenomes-Tr:CAB15157" /db_xref="GOA:Q99027" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10380" /db_xref="UniProtKB/Swiss-Prot:Q99027" /translation="MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQ FMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHLKWGYLSHINSLDILRSGKKIHL KDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISI AYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIF NLGIEFFQDYLQVDIDFLATLNLVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLIL TNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQFVANKMFDIEFILG RMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFR LKRFSEKFNYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKV IFLDKHEVGPDWNFYQEEFENVTSEIGKIIEVNQGFLMKVGERGGSSYVLLCLSNINT PRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLMFAIEEK QRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVIS MTRETCHELRPQLLYDLGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLY RIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDGVGFDQEKNTEHSMSMGLSGI KERVRALDGRLRIETSEGKGFKADIEIEL*" /label="comP CDS" gene complement(2687093..2689402) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /label="comP gene" promotor_-35 2688087..2688094 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2688108..2688127 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2688123 /Source="Nicolas_upshifts" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 2688996..2689967 /Source="Nicolas_S_feature" /locus_tag="new_3255432_3256404" /HighExp="S8, C30, S7, Gly, Lbstat, Fru, C90, Pyr, G135, M/G" /AntisenseName="comX" /AntisenseCor="-2.6572990440080099E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.606" /TUlongSig="NA" /TUlongPSig="NA" /label="S1214" upshifts 2688996 /Source="Nicolas_upshifts" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2689008..2689024 /Source="Nicolas_upshift_promotors" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2689417..2689584) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484; Product type f: factor" /codon_start=1 /transl_table=11 /product="competence pheromone precursor (pheromone peptide aa 46->55, geranyl-modified)" /protein_id="NP_391048.1" /db_xref="EnsemblGenomes-Gn:BSU31700" /db_xref="EnsemblGenomes-Tr:CAB15158" /db_xref="GOA:P45453" /db_xref="InterPro:IPR009233" /db_xref="SubtiList:BG11324" /db_xref="UniProtKB/Swiss-Prot:P45453" /translation="MQDLINYFLNYPEALKKLKNKEACLIGFDVQETETIIKAYNDYY LADPITRQWGD*" /label="comX CDS" gene complement(2689417..2689584) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /label="comX gene" CDS complement(2689572..2690470) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoprenyl transferase (pre-ComX modification)" /protein_id="NP_391049.2" /db_xref="EnsemblGenomes-Gn:BSU31710" /db_xref="EnsemblGenomes-Tr:CAB15159" /db_xref="GOA:P33690" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033965" /db_xref="SubtiList:BG10379" /db_xref="UniProtKB/Swiss-Prot:P33690" /translation="MKEIVEQNIFNEDLSQLLYSFIDSKETFSFAESTILHYVVFGGE NLDVATRLGAGIEILILSSDIMDDLEDEDNHHALWMKINRSESLNAALSLYTVGLTSI YSLNNNPLIFKYVLKYVNEAMQGQHDDITNKSKTEDESLEVIRLKCGSLIALANVAGV LLATGEYNETVERYSYYKGIIAQISGDYYVLLSGNRSDIEKNKHTLIYLYLKRLFNDA SEDLLYLISHKDLYYKSLLDKEKFQEKLIKAGVTQYISVLLEIYKQKCISAIEQLNLD KEKKS**RNAY*VIQRGIQDARP" /label="comQ CDS" gene complement(2689572..2690470) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /label="comQ gene" S_feature complement(2690471..2690584) /Source="Nicolas_S_feature" /locus_tag="new_3256908_3257021_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, S4, T2.30H, M0t90, S5, M40t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1215" promotor_-10 complement(2690578..2690597) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2690584) /Source="Nicolas_upshifts" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2690611..2690617) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2690655..2690795) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="pleiotropic regulator" /protein_id="NP_391050.1" /db_xref="EnsemblGenomes-Gn:BSU31720" /db_xref="EnsemblGenomes-Tr:CAB15160" /db_xref="GOA:Q99039" /db_xref="InterPro:IPR012554" /db_xref="SubtiList:BG10378" /db_xref="UniProtKB/Swiss-Prot:Q99039" /translation="MEKKLEEVKQLLFRLELDIKETTDSLRNINKSIDQLDKYNYAMK IS*" /label="degQ CDS" gene complement(2690655..2690795) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /label="degQ gene" downshifts complement(2690684) /Source="Nicolas_upshifts" /id="D1639" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="2.48672" /MaxDrop="4.10905" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2470" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2690796..2690882) /Source="Nicolas_S_feature" /locus_tag="new_3257233_3257319_c" /HighExp="S2, S4, BC, M9-stat, S5, S3, S6, BT, S8, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.843" /TUlongSig="NA" /TUlongPSig="NA" /label="S1216" promotor_-10 complement(2690866..2690885) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2690882) /Source="Nicolas_upshifts" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2690899..2690905) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2690982..2691000) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2690992) /Source="Nicolas_upshifts" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2691015..2691021) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2691017..2691142 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514001.1" /translation="MLKLRKILNLLDFNGFRIFTKQDYSPSYRIFKIEYAILGVS*" /label="hypothetical protein CDS" gene 2691017..2691142 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /label="gene" S_feature complement(2691170..2691599) /Source="Nicolas_S_feature" /locus_tag="new_3257607_3258036_c" /HighExp="LBGtran, G135, C90, Lbtran, Mt0, Lbexp, G150, G180, M40t45, C30" /AntisenseName="yuzC" /AntisenseCor="-0.77553193168722701" /AntisenseRegPval="-54.5" /CDS_PredictionProba="0.143959" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1217" promotor_-35 2691195..2691200 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2691212) /Source="Nicolas_upshifts" /id="D1640" /incds=0 /nref=23 /ntot=170 /MaxReadThrough="2.53578" /MaxDrop="3.52021" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2473" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 2691215..2691233 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2691217 /Source="Nicolas_upshifts" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="upshifts" CDS 2691256..2691624 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391051.2" /db_xref="EnsemblGenomes-Gn:BSU31730" /db_xref="EnsemblGenomes-Tr:CAB15161" /db_xref="InterPro:IPR016559" /db_xref="SubtiList:BG14052" /db_xref="UniProtKB/Swiss-Prot:O32089" /translation="MRYRYPWFYVYPYEVRRPPAPANNIDTFIRSAKQAAGIFADAQL VLSRIAGSRELSRRILTAAEQSDKQTIRRLIKQMGVRHEVDTVFNPDGIYISLIGTQS RMILALRWSEDRNHFASIRL*" /label="cotIC CDS" gene 2691256..2691624 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /label="cotIC gene" CDS complement(2691600..2692829) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /EC_number="3.1.4.52" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17153922, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17153922, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclic di-GMP phosphodiesterase" /protein_id="NP_391052.1" /db_xref="EnsemblGenomes-Gn:BSU31740" /db_xref="EnsemblGenomes-Tr:CAB15162" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR013976" /db_xref="InterPro:IPR014408" /db_xref="InterPro:IPR035919" /db_xref="SubtiList:BG10377" /db_xref="UniProtKB/Swiss-Prot:P14203" /translation="MRVFVARQPIFNRKEQVVAYELLYRESEENVYSAKDGDQATTDL VINSFLNIGIEKLTEGKRCFVNFTESLMFSNLPTSFNPKQLVIEILEDIPITPALISR CKELKKMGYMLALDDFYAINPQDEDLLEKLMSYIDILKIDFLKTTRMERRTILQTYGC RGLIFLAEKVETRKEYKQAVQDGFQLFQGYFFSEPRIISGHDLSTHFYSYYELLNELS KEQPNIKRVTEYIERDLSLSYQILKFLNSSHSRLSQKIESIQQAIMLLGFNEIKRWIY ILSFKDLSRKGHSSKHEIIKISLIRAKLCELLARKTSRPQPASYMLIGMFSLIDTLLH REIEEIVQELPLKDEVGQALLGHQNDYYQMLELVKLIESNNWDTCSELGNQLDKEEAY ECYLEALEWCHNLMDAK*" /label="pdeH CDS" gene complement(2691600..2692829) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /label="pdeH gene" S_feature 2691625..2692938 /Source="Nicolas_S_feature" /locus_tag="new_3258062_3259375" /HighExp="S4, S5, S3, S6, LoTm, S8, S7, T5.0H, B36, Pyr" /AntisenseName="yuxH" /AntisenseCor="-0.78363066752642896" /AntisenseRegPval="-56.4" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1218" promotor_-10 complement(2692864..2692883) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2692883) /Source="Nicolas_upshifts" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="upshifts" downshifts 2692896 /Source="Nicolas_upshifts" /id="D1641" /incds=0 /nref=6 /ntot=30 /MaxReadThrough="1.76106" /MaxDrop="4.58543" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2692898..2692905) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2692966..2694438) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /EC_number="6.3.4.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4296374, 12682299, 16199587, 24564896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate phosphoribosyltransferase" /protein_id="NP_391053.1" /db_xref="EnsemblGenomes-Gn:BSU31750" /db_xref="EnsemblGenomes-Tr:CAB15163" /db_xref="GOA:O32090" /db_xref="InterPro:IPR006405" /db_xref="InterPro:IPR007229" /db_xref="InterPro:IPR036068" /db_xref="SubtiList:BG13966" /db_xref="UniProtKB/Swiss-Prot:O32090" /translation="MLEYGFKDDSLSLHTDLYQINMAETYWRDGIHEKKAIFELFFRR LPFENGYAVFAGLEKAIEYLENFKFTDSDLSYLQDELGYHEDFIEYLRGLSFTGSLYS MKEGELVFNNEPIMRVEAPLVEAQLIETALLNIVNYQTLIATKAARIKGVIGDEVALE FGTRRAHEMDAAMWGARAALIGGFSATSNVRAGKRFNIPVSGTHAHALVQAYRDEYTA FKKYAETHKDCVFLVDTYDTLRSGMPNAIRVAKEFGDRINFIGIRLDSGDLAYLSKKA RKMLDEAGFTDAKVIASSDLDEHTIMNLKAQGARIDVWGVGTKLITAYDQPALGAVYK LVAIEEDGKMVDTIKISSNPEKVTTPGRKKVYRIINQSNHHSEGDYIALYDEQVNDQK RLRMFHPVHTFISKFVTNFYAKDLHELIFEKGILCYQNPEISDIQQYVQDNLSLLWEE YKRISKPEEYPVDLSEDCWSNKMQRIHEVKSRIEEELEEE*" /label="pncB CDS" gene complement(2692966..2694438) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /label="pncB gene" downshifts complement(2692976) /Source="Nicolas_upshifts" /id="D1642" /incds=0 /nref=200 /ntot=267 /MaxReadThrough="4.08676" /MaxDrop="6.72747" /score="16.2382739" /energy="-14.5" /TU="NA" /idTUdmin="U2475" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" misc_feature 2694319..2694323 /Source="Nicolas_upshift_promotors" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2694326 /Source="Nicolas_upshifts" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2694436 /Source="Nicolas_upshifts" /id="D1643" /incds=0 /nref=1 /ntot=123 /MaxReadThrough="1.2059" /MaxDrop="3.08208" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS complement(2694454..2695005) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /EC_number="3.5.1.19" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15135535, 17382284, 18616465, 24340054, 24512664; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinamidase; NAD salvage pathway" /protein_id="NP_391054.1" /db_xref="EnsemblGenomes-Gn:BSU31760" /db_xref="EnsemblGenomes-Tr:CAB15164" /db_xref="GOA:O32091" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG13965" /db_xref="UniProtKB/Swiss-Prot:O32091" /translation="MKKALICIDYTNDFVASDGKLTCGEPGRMIEEAIVNLTKEFITN GDYVVLAVDSHDEGDQYHPETRLFPPHNIKGTEGKDLYGKLLPLYQKHEHEPNVYYME KTRYSAFAGTDLELKLRERQIGELHLAGVCTDICVLHTAVDAYNKGFRIVVHKQAVAS FNQEGHAWALSHFANSIGAQVAE*" /label="pncA CDS" gene complement(2694454..2695005) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /label="pncA gene" promotor_-10 complement(2695027..2695046) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2695040) /Source="Nicolas_upshifts" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2695059..2695066) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2695102..2695500) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391055.1" /db_xref="EnsemblGenomes-Gn:BSU31770" /db_xref="EnsemblGenomes-Tr:CAB15165" /db_xref="InterPro:IPR012543" /db_xref="InterPro:IPR029064" /db_xref="PDB:2OHW" /db_xref="SubtiList:BG13964" /db_xref="UniProtKB/Swiss-Prot:O32092" /translation="MSEDKMDLYLQQGMYGPLETKPDERHLFLGSLRERVVLALTKGQ VLRSKPYKEAEHELKNSHNVTLLINGELQYQSYSSYIQMASRYGVPFKIVSDLQFHTP LGIVIAADIAVNRELIYIQDDIYNRSVLKS*" /label="yueI CDS" gene complement(2695102..2695500) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /label="yueI gene" S_feature complement(2695501..2695571) /Source="Nicolas_S_feature" /locus_tag="new_3261938_3262008_c" /HighExp="Etha, dia5, Diami, dia15, H2O2, LBGtran, LPhT, G135, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1219" CDS complement(2695572..2695820) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391056.1" /db_xref="EnsemblGenomes-Gn:BSU31780" /db_xref="EnsemblGenomes-Tr:CAB15166" /db_xref="InterPro:IPR020260" /db_xref="SubtiList:BG13963" /db_xref="UniProtKB/Swiss-Prot:O32093" /translation="MKIRKANINTQTGMITDVYLHENRKELRTLVAVPQLEWSTIISY EEDKATLPERLEASLRRHTEETPAGELAKKIIHWVTEM*" /label="yueH CDS" gene complement(2695572..2695820) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /label="yueH gene" promotor_-10 complement(2695843..2695862) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2695854) /Source="Nicolas_upshifts" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2695878..2695881) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2695893..2696114) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_391057.1" /db_xref="EnsemblGenomes-Gn:BSU31790" /db_xref="EnsemblGenomes-Tr:CAB15167" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13962" /db_xref="UniProtKB/Swiss-Prot:O32094" /translation="MPAIVGPIYIMSVTDNAAASFGDVFAISPKSVAHSGAGSGTFQL GDFVKINNQTSKTLFKDADITDETVSFNG*" /label="yueG CDS" gene complement(2695893..2696114) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /label="yueG gene" downshifts complement(2695920) /Source="Nicolas_upshifts" /id="D1644" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="3.65047" /MaxDrop="4.3681" /score="19.032155" /energy="-12.6" /TU="U2477,U2479,U2482" /idTUdmin="U2482" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2696108 /Source="Nicolas_upshifts" /id="D1645" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="1.17049" /MaxDrop="3.0193" /score="-7.47675224" /energy="-6.7" /TU="NA" /idTUdmin="U2480" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2696132..2696151) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2696138) /Source="Nicolas_upshifts" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2696164..2696173) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2696174..2697283) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391058.1" /db_xref="EnsemblGenomes-Gn:BSU31800" /db_xref="EnsemblGenomes-Tr:CAB15168" /db_xref="GOA:O32095" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13961" /db_xref="UniProtKB/Swiss-Prot:O32095" /translation="MLKSKVHFWTLQILFVLLIIFVATKVSFVFQPFIVFISTLFFPM LIAGILYFIFNPVVRLLEKKIPRTLSILLIYLLFIGLLAFISASVGPIITAQVTGLFN NLPDYIKQIQALTKDLSHSQWFTWMMNQDYVSISKIEQSLTSFLQNLPQNITSSLSAV FGVVTNITLVIITVPFILFYMLKDGHRFPHLAVKILPASYRTEGLKIFKDLSDTLAAY FQGQLLICLFVGTACFIGYLIAGLPYALILGIVMAITNIIPYVGPFLGAAPAVIVGFM DSPAKALFAIIVVVIVQQLDGNLLSPLVIGKRLNTHPLTIILLLIGAGSFGGILGMIL AVPVYAVVKAFFLNIVRLIKLRQRSRLEENAKPAE*" /label="yueF CDS" gene complement(2696174..2697283) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /label="yueF gene" promotor_-35 2696935..2696942 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2696957..2696976 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2696966..2697360 /Source="Nicolas_S_feature" /locus_tag="new_3263403_3263797" /HighExp="dia15, S8, H2O2, dia5, LBGstat, Paraq, C30, S7, Diami, G180" /AntisenseName="yueF" /AntisenseCor="0.28555063485711402" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1220" upshifts 2696966 /Source="Nicolas_upshifts" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2697331..2697350) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-10" upshifts complement(2697347) /Source="Nicolas_upshifts" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="upshifts" S_feature complement(2697349..2697789) /Source="Nicolas_S_feature" /locus_tag="new_3263786_3264226_c" /HighExp="Diami, S8, H2O2, S7, C90, Paraq, Salt, S1, dia15, dia5" /AntisenseName="yuzE" /AntisenseCor="0.47136608606324898" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1221" promotor_-35 2697352..2697354 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2697362 /Source="Nicolas_upshifts" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2697364..2697369) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-35" promotor_-10 2697370..2697389 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2697398..2697787 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391059.1" /db_xref="EnsemblGenomes-Gn:BSU31810" /db_xref="EnsemblGenomes-Tr:CAB15169" /db_xref="InterPro:IPR016789" /db_xref="InterPro:IPR019270" /db_xref="SubtiList:BG14054" /db_xref="UniProtKB/Swiss-Prot:O32096" /translation="MKAVTYDTDSELAYIYVLPPKKNRNVRTEELRVNDCLLLDISQD GKIAGFECFGEAAHLCAPFAGKSRLYVKDSDGYHFRVCQHASVRSCYTVYRVTFCFSD GDYQEFAGFDLDGTMYHSAFLQRLTEK*" /label="yuzE CDS" gene 2697398..2697787 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /label="yuzE gene" CDS complement(2697828..2698064) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391060.1" /db_xref="EnsemblGenomes-Gn:BSU31820" /db_xref="EnsemblGenomes-Tr:CAB15170" /db_xref="InterPro:IPR020139" /db_xref="SubtiList:BG14055" /db_xref="UniProtKB/Swiss-Prot:O32097" /translation="MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDTVRGRLID VKPDHITIEGARNSVCLIRIQHMISVTPDYSERV*" /label="yuzF CDS" gene complement(2697828..2698064) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /label="yuzF gene" downshifts complement(2697834) /Source="Nicolas_upshifts" /id="D1646" /incds=0 /nref=12 /ntot=37 /MaxReadThrough="5.19136" /MaxDrop="5.1675" /score="30.7642328" /energy="-9.9" /TU="U2482" /idTUdmin="U2481" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2698084..2698103) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2698098) /Source="Nicolas_upshifts" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2698100..2698240) /Source="Nicolas_S_feature" /locus_tag="new_3264537_3264677_c" /HighExp="BT, Diami, S8, Etha, Sw, C90, Salt, B36, LPhT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.998, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1222" promotor_-35 complement(2698117..2698126) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2698241..2698771) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /EC_number="3.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_391061.1" /db_xref="EnsemblGenomes-Gn:BSU31830" /db_xref="EnsemblGenomes-Tr:CAB15171" /db_xref="GOA:O32098" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="SubtiList:BG13960" /db_xref="UniProtKB/Swiss-Prot:O32098" /translation="MRKVTLMDVFTHPIAQKYLQRSGVAHAIACAYHAYRLSVKADIN PDLAAKAALLHDIGHYEWYTDGKWDYEKYKRNDIHAIKGAERAHKLLIRLGEEPKAAK EIALAILLHTDSYLPEGELDKNTLQQIVKKADELDEEPGGHHHYRQIDPSTARKKIEK LDQLIDQAQASVIKPV*" /label="yueE CDS" gene complement(2698241..2698771) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /label="yueE gene" promotor_-10 complement(2698791..2698810) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-10" upshifts complement(2698802) /Source="Nicolas_upshifts" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="upshifts" S_feature complement(2698804..2698890) /Source="Nicolas_S_feature" /locus_tag="new_3265241_3265327_c" /HighExp="BT, S8, S6, S7, B36, Etha, S5, S4, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1223" promotor_-35 complement(2698822..2698830) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-35" promotor_-10 complement(2698885..2698904) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2698892) /Source="Nicolas_upshifts" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2698918..2698927) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2698969..2699700) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /EC_number="1.1.1.320" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11745140, 21670841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="benzil reductase (benzoin forming)" /protein_id="NP_391062.1" /db_xref="EnsemblGenomes-Gn:BSU31840" /db_xref="EnsemblGenomes-Tr:CAB15172" /db_xref="GOA:O32099" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13959" /db_xref="UniProtKB/Swiss-Prot:O32099" /translation="MELYIITGASKGLGQAIALQALEKGHEVHALSRTKTDVSHKKLT QHQIDLINLEEAEQQFETLLSSIDSDRYSGITLINNAGMVTPIKRAGEASLDELQRHY QLNLTAPVLLSQLFTKRFASYSGKKTVVNITSGAAKNPYKGWSAYCSSKAGLDMFTRT FGFEQEDEELPVNMISFSPGVMDTEMQAVIRSSSKKDFHHIERFRKLNETGSLRSPDF IAGTLLSLLEKGTENGRIYDIKEFL*" /label="bznD CDS" gene complement(2698969..2699700) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /label="bznD gene" downshifts complement(2698999) /Source="Nicolas_upshifts" /id="D1647" /incds=0 /nref=183 /ntot=253 /MaxReadThrough="2.76356" /MaxDrop="5.18507" /score="30.7642328" /energy="-9.9" /TU="NA" /idTUdmin="U2484" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2699715..2699734) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2699726) /Source="Nicolas_upshifts" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2699749..2699756) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2699763..2700218) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YueC protein" /protein_id="NP_391063.1" /db_xref="EnsemblGenomes-Gn:BSU31850" /db_xref="EnsemblGenomes-Tr:CAB15173" /db_xref="GOA:O32100" /db_xref="InterPro:IPR018920" /db_xref="InterPro:IPR020212" /db_xref="SubtiList:BG13958" /db_xref="UniProtKB/Swiss-Prot:O32100" /translation="MLSFSLFIPSAAAAQTEENTDVAPNQYEKKDIEIDTNYLHEDTY YEEKTELPEEQKDITFDKPKDKDAELIKDLFTSTNAEDSNTIAAQSKQLGITFAEKPM TKTSSTETEDEQETSSLLLPMIYVVLILLGIAGIVFLIPKVTAQENKKA*" /label="yueC CDS" gene complement(2699763..2700218) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /label="yueC gene" promotor_-35 2700171..2700177 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2700192..2700210 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2700200..2702567 /Source="Nicolas_S_feature" /locus_tag="new_3266637_3269004" /HighExp="Etha, Gly, Sw, Salt, LoTm, C30, BT, HiTm, Mal, G135" /AntisenseName="yueB" /AntisenseCor="-9.3455707286730305E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1224" upshifts 2700200 /Source="Nicolas_upshifts" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2700250..2703480) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022, 27179995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022, 27179995; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system; calcium-dependent phage SPP1 attachment site" /protein_id="NP_391064.1" /db_xref="EnsemblGenomes-Gn:BSU31860" /db_xref="EnsemblGenomes-Tr:CAB15174" /db_xref="GOA:O32101" /db_xref="InterPro:IPR023838" /db_xref="SubtiList:BG13957" /db_xref="UniProtKB/Swiss-Prot:O32101" /translation="MTEQRKSLIKLISAVIIILLLPVLFFRFIGDDPTKKAVNSTRQI AVVNEDTGVLSDEVKSDEEDKSAQFGKEVAAVLGERPDYSWTVVNRSAAETGLASKKY DAIVYIPSDFSKNILSYDKDHPQKATLEFSIQDNLNAVNKEKVQRELEDAQKTMNKKM SALYWNFVSQKVDNIRGEFDKIVNKESEFQNVMYNFYKPSSNDLAGEIKQQKDLIDEL KKSMNEAQGTTKEKASTAEEAKNTLKEFIDTVERYKEYQENQKKLLLAAQDSTQQQIR TGLDAIQAQQKANQFSERMSGLATGIGQAKTQIGLTNLALNNAEKLRQNQVPLQEMGM KKIENDMFNAFLSRYKSQYEAIKYQNLNQLQENIGKNRLSLLKPKESDEKEDGEDTSD NKDDTDKEDIEDIKLDLEKQRDELKNVATEIKDISEGLKEPEQEKPTTPDAEEPSTDD SPNTEEPSNDIPTSDDQPTNEDTGSSEEGTQDNGSQNDVQTNIETGQKHQESSKNVPE QDTNTENTGTSKTDFSLIELADENDGSNQSDGLQGDGADGETDISGAKKRLNEAAIKL EEIENALQEKQEEHNNKLEKHIDELNQEIKELNKTVSKLNDQIGDLTKKLVDFDNNVN DAYRLIYNLEDEIIQTLQSRGYIDQKEKLSSIFSSRIETDNISNLMKYYNSLNLYKST LNDNLDLGSLTIIKGEVIQEQDGNVQSVLALTPEESASWEALKNNTMQTDEDINSFID GMTKFADDYSGYIRDSQAGVLDELTKISESAAKASEQLVTGATQESATFSNDGLSGTM ALSVQDTVGQEVLQMSDMMGSLSDRQSGIIDYTTNMQQSVNDVQAKADTLNNNWGKNV ASTKLVRNDVYGILGNTLVDGQNNGYVYDYLANPLKISGEVPEEKIQTVPPVVILVIV LISSLLIGYFSSYYQNAPLLVKGALFGILNILVGLMISLFGLNIYSLPDDQTIKWSVF TILLLVASSAFIRTAFRFGSIPGWVASAAMILFYVAPLIDLIMPNFTFEDPVSKVYID IQYGTGHLFTMGITVLLIITVIAVALPLIIRLMAEHTAESDETYEA*" /label="yueB CDS" gene complement(2700250..2703480) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /label="yueB gene" CDS complement(2703477..2707964) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system FtsK/SpoIIIE family ATPase" /protein_id="NP_391066.2" /db_xref="EnsemblGenomes-Gn:BSU31875" /db_xref="EnsemblGenomes-Tr:CAB15176" /db_xref="GOA:C0SPA7" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR022206" /db_xref="InterPro:IPR023839" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12375" /db_xref="UniProtKB/Swiss-Prot:C0SPA7" /translation="MSLLWVFYQNNVQKLNLSNLPSSHPVTIGPDVKDSVTISTIPFN SGVISLKRKESGGQYEVFLGNDCLGTIETDISFTLQTDQQDIRLILTGSEPEKSVYFT GNRDEIVCSSEKTNADIYLNPQDFAFAEQSTFSLLRAGGSWSVRPESGTIFLNGEKIN ANTPLKPGDEIFWNFTQMRVTEQDLLEIVHYAQFETALTETVKPSTEMQKKYPQYRRT PRMVYDLPDDRVSFSFPSQESDQTNRGLWLVILPPLVMLIVMGVVAIIQPRGIFILVS LAMFMMTLITSTVQYFRDKNQRKKREEKRERVYKLYLDNKRKELQALAEKQKQVLEFH FPSFEQMKYLTSEISDRIWEKSLESKDYLQLRLGTGTVPSSYEINMSGGDLANRDIDD LMEKSQHMQRVYKDIRNAPVTVDLAEGPMGLVGKSQIVKNEIHQLIGQLSFFNSYHDL RFVFIFHEEEYKDWEWMKWLPQFQMPHIYAKGFIYNEQTRDQLLSSLYELIRERDLED DKEKLQFKPHFVFVITNQQLISEHVILEYLEGQHEHLGISTIVAAETKESLSENITTL VRYINEHEGDILIQKKKAVRIPFRLDHHQREDNERFSRTLRTLNHQVGITNSIPETVS FLELFHAKEVKEIGIQQRWLTSESSKSLSVPIGYKGKDDIVYLNLHEKAHGPHGLLAG TTGSGKSEFLQTYILSLAVHFHPHEAAFLLIDYKGGGMAQPFRNIPHLLGTITNIEGS KNFSMRALASIKSELKKRQRLFDQYQVNHINDYTKLYKQGKAEVAMPHLFLISDEFAE LKSEEPDFIRELVSAARIGRSLGVHLILATQKPGGIIDDQIWSNSRFKVALKVQDATD SKEILKNSDAANITVTGRGYLQVGNNEVYELFQSAWSGAPYLEEVYGTEDEIAIVTDT GLIPLSEVDTEDNAKKDVQTEIEAVVDEIERIQDEMGIEKLPSPWLPPLAERIPRTLF PSNEKDHFHFAYVDEPDLQRQAPIAYKMMEDGNIGIFGSSGYGKSIAAATFLMSFADV YTPEELHVYIFDFGNGTLLPLAKLPHTADYFLMDQSRKIEKFMIRIKEEIDRRKRLFR EKEISHIKMYNALSEEELPFIFITIDNFDIVKDEMHELESEFVQLSRDGQSLGIYFML TATRVNAVRQSLLNNLKTKIVHYLMDQSEGYSIYGRPKFNLEPIPGRVIIQKEELYFA QMFLPVDADDDIGMFNELKSDVQKLQGRFASMEQPAPIPMLPESLSTRELSIRFKLER KPLSVPIGLHEETVSPVYFDLGKHKHCLILGQTQRGKTNVLKVMLEHLIDDETEMIGL FDSIDRGLSHYAKESDVSYLETKEDIEQWIETAEDIFKTREAMYVEAVRQGDAQNLRF SQVVLMIDGITRFQQTIDTRIQDRLANFMKSYAHLGFSFIPGGNHSEFSKGYDSLTTE MKQIRHAILLMKKSEQNVIPLPYQRQEPEIQPGFGYVVENGKEQKVQIPLCSAERESA R*" /label="yukAB CDS" gene complement(2703477..2707964) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /label="yukAB gene" promotor_-35 2707239..2707245 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2707260..2707278 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2707266..2708228 /Source="Nicolas_S_feature" /locus_tag="new_3273703_3274665" /HighExp="Etha, Sw, Gly, Salt, B60, M9-stat, LoTm, T0.30H, BT, LPhT" /AntisenseName="yukB" /AntisenseCor="-0.26212584196591598" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1225" upshifts 2707266 /Source="Nicolas_upshifts" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2708025..2709380) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /function="11.1: Protein and peptide secretion and trafficking" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukC protein" /protein_id="NP_391067.1" /db_xref="EnsemblGenomes-Gn:BSU31890" /db_xref="EnsemblGenomes-Tr:CAB15177" /db_xref="GOA:P71070" /db_xref="InterPro:IPR018778" /db_xref="SubtiList:BG12376" /db_xref="UniProtKB/Swiss-Prot:P71070" /translation="MSGEQKSYLENQLEAVAEKTDAGYTFTFQREKIKLLDGLEANVI KDINPFFHKEIDVTDDEVIITIQPPSSYKAFRFMKAKDKKSKWQFAYQLVQAVQQHNL SRLNLIVAPENIVFDKGLTPYFLHYGVKESIPPYERDEERVWQELKAAAALAVDGAFA FEDYLKFNETLTFSAEAKAILDAESYDDLLELIQTHIDELEAKAKTYIHIPRKKWNIQ RYIGLGLIVLLVPALIYSMYALFFAQPKHQAIVDSNRAFLNKQYSEVISTLSKYDAES LPESVQYQLATSYVEVENLGSAKTKNIENNLVTLQSDPQHFLYWIDYGRGEYKEAISI GRKLEYNDYIYFALAKYKQQLLSEDTNDEDIQKELDSVNSELEKAQKERQENKQSNSE TSLVDTSEEQTQTDEEKQAEEKAAEEKAAAEEKAKKEEQKEKEDEKKETEKKDEKKDD K*" /label="yukC CDS" gene complement(2708025..2709380) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /label="yukC gene" downshifts complement(2708046) /Source="Nicolas_upshifts" /id="D1648" /incds=0 /nref=5 /ntot=116 /MaxReadThrough="6.33518" /MaxDrop="3.1562" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=5823 /isTUend="FALSE" /label="downshifts" CDS complement(2709395..2709634) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /function="11.1: Protein and peptide secretion and trafficking" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukD protein" /protein_id="NP_391068.1" /db_xref="EnsemblGenomes-Gn:BSU31900" /db_xref="EnsemblGenomes-Tr:CAB15178" /db_xref="InterPro:IPR014921" /db_xref="InterPro:IPR024962" /db_xref="InterPro:IPR029071" /db_xref="PDB:2BPS" /db_xref="SubtiList:BG12377" /db_xref="UniProtKB/Swiss-Prot:P71071" /translation="MYIDITIDLKHYNGSVFDLRLSDYHPVKKVIDIAWQAQSVSMPP REGHWIRVVNKDKVFSGECKLSDCGITNGDRLEIL*" /label="yukD CDS" gene complement(2709395..2709634) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /label="yukD gene" CDS complement(2709704..2709997) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:11973144, 15576783, 22720735, 24798022, 24828531" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11973144, 15576783, 22720735, 24798022, 24828531; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small WGX100 secreted protein (ESX-dependent secretion)" /protein_id="NP_391069.2" /db_xref="EnsemblGenomes-Gn:BSU31910" /db_xref="EnsemblGenomes-Tr:CAB15179" /db_xref="GOA:C0SP85" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12378" /db_xref="UniProtKB/Swiss-Prot:C0SP85" /translation="MAGLIRVTPEELRAMAKQYGVESQEVLNQVDRLNRMISDLKSMW EGASSEAFADQYEQLKPSFIKMSDLLQDVNQQLDQTANTLESTDQDIANQIRG*" /label="yukE CDS" gene complement(2709704..2709997) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /label="yukE gene" downshifts complement(2709714) /Source="Nicolas_upshifts" /id="D1649" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="6.21938" /MaxDrop="7.50121" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=4155 /isTUend="FALSE" /label="downshifts" downshifts 2709991 /Source="Nicolas_upshifts" /id="D1650" /incds=0 /nref=1 /ntot=26 /MaxReadThrough="2.85718" /MaxDrop="3.33739" /score="43.0917981" /energy="-17.1" /TU="NA" /idTUdmin="U2487" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" S_feature complement(2709998..2710076) /Source="Nicolas_S_feature" /locus_tag="new_3276435_3276513_c" /HighExp="T-1.10H, T1.0H, T-0.40H, T1.30H, BI, T2.30H, T3.0H, T-2.40H, T2.0H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1226" promotor_-35 2710039..2710046 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2710056..2710075) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2710057 /Source="Nicolas_upshifts" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2710061..2710078 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2710076) /Source="Nicolas_upshifts" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2710090..2710097) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2710135..2710140 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2710155..2710174 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2710167..2710273 /Source="Nicolas_S_feature" /locus_tag="new_3276604_3276710" /HighExp="S8, C30, S7, S6, Pyr, Glucon, B60, LoTm, C90, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="0.523, 0.76" /TUlongSig="NA" /TUlongPSig="NA" /label="S1227" upshifts 2710167 /Source="Nicolas_upshifts" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2710342..2710348 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2710362..2710381 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2710365 /Source="Nicolas_upshifts" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2710470..2710473 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-35" upshifts 2710482 /Source="Nicolas_upshifts" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="upshifts" promotor_-10 complement(2710485..2710504) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2710489..2710508 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-10" upshifts complement(2710507) /Source="Nicolas_upshifts" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2710518..2711786 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22797752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22797752; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AdeR-alanine)" /protein_id="NP_391070.2" /db_xref="EnsemblGenomes-Gn:BSU31920" /db_xref="EnsemblGenomes-Tr:CAB15180" /db_xref="GOA:P71073" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12379" /db_xref="UniProtKB/Swiss-Prot:P71073" /translation="MSKRNQARKVGRFMTMPNDPFKYSFDRLEDVADHISDVLRCPIT IEDVNHKLLAYSTHSDCTDPARTSTIIGRRVPEKVINKLWKDGTIPALLKTDQPIRVK QIDEVGLSNRVAISIWKNKQVLGFIWALEIQKTLSDEDLLTLQMAAKAVKNKLLKLQI RKTKNEERSQEFFWKMLTGHIHQEDDMADGFHKLGMAAPSEFSVMIIRINGELTEKIE QQLQYLQETTQQVYVLLATVDSNELIILTSPKTDHPFQDLKQFALSTQKQLKERYKIE DVSIAFGGIYNSISFVSRSYQEALSVLKTKERFAEETKHLFSFSELGIYQYLDVLNEK RKQAGHYNYSLSKLEQYDRDHQSNMVETLERFIEADSNVNTASKLLNIHVNTLNYRLK RISQIAEIDLKNVNQKFTIYLDIKLRHMDL*" /label="adeR CDS" gene 2710518..2711786 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /label="adeR gene" promotor_-35 complement(2710519..2710526) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2711846..2711865 /Source="Nicolas_upshift_promotors" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2711851 /Source="Nicolas_upshifts" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2711888..2713024 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /EC_number="1.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:488097, 8226620, 22720735, 22797752, 26202482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 488097, 8226620, 22720735, 22797752, 26202482; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-alanine dehydrogenase (NAD-dependent)" /protein_id="NP_391071.1" /db_xref="EnsemblGenomes-Gn:BSU31930" /db_xref="EnsemblGenomes-Tr:CAB15181" /db_xref="GOA:Q08352" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR007886" /db_xref="InterPro:IPR008141" /db_xref="InterPro:IPR008142" /db_xref="InterPro:IPR008143" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10468" /db_xref="UniProtKB/Swiss-Prot:Q08352" /translation="MIIGVPKEIKNNENRVALTPGGVSQLISNGHRVLVETGAGLGSG FENEAYESAGAEIIADPKQVWDAEMVMKVKEPLPEEYVYFRKGLVLFTYLHLAAEPEL AQALKDKGVTAIAYETVSEGRTLPLLTPMSEVAGRMAAQIGAQFLEKPKGGKGILLAG VPGVSRGKVTIIGGGVVGTNAAKMAVGLGADVTIIDLNADRLRQLDDIFGHQIKTLIS NPVNIADAVAEADLLICAVLIPGAKAPTLVTEEMVKQMKPGSVIVDVAIDQGGIVETV DHITTHDQPTYEKHGVVHYAVANMPGAVPRTSTIALTNVTVPYALQIANKGAVKALAD NTALRAGLNTANGHVTYEAVARDLGYEYVPAEKALQDESSVAGA*" /label="ald CDS" gene 2711888..2713024 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /label="ald gene" downshifts 2713024 /Source="Nicolas_upshifts" /id="D1651" /incds=0 /nref=42 /ntot=190 /MaxReadThrough="5.86626" /MaxDrop="4.4689" /score="41.2794059" /energy="-14.2" /TU="U2493" /idTUdmin="U2493" /TUdmin="-769" /isTUend="FALSE" /label="downshifts" promotor_-35 2713073..2713081 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2713091 /Source="Nicolas_upshifts" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2713093..2713111 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2713136..2713813 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391073.2" /db_xref="EnsemblGenomes-Gn:BSU31945" /db_xref="EnsemblGenomes-Tr:CAB15183" /db_xref="InterPro:IPR019268" /db_xref="SubtiList:BG12380" /db_xref="UniProtKB/Swiss-Prot:C0SPB1" /translation="MAVQQYGVLKGIVLDMKRETDDDSPHFQVKMLGEENTYYRCAIN VMSSSEESEVLYLADDQFDSGSITILPNMPYGYTRINEANREVALDYVRGNLFDPREM KPLPHEITGPDNDLNDFIETYMKKAQDEKTPVYIFGSKFGPEQAADKIFGFTPTNGMH NIHMNQGNAMDTRWKKDNGSWHDGGILIQFADQWAAVFLAFLSQSWCTDENGNPVRDC DHTQTSA*" /label="yukJ CDS" gene 2713136..2713813 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /label="yukJ gene" downshifts 2713797 /Source="Nicolas_upshifts" /id="D1652" /incds=0 /nref=37 /ntot=185 /MaxReadThrough="3.39608" /MaxDrop="5.40829" /score="9.49891506" /energy="-12" /TU="U2494" /idTUdmin="U2493" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2713857..2714066) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11112781, 20845982, 21890635, 24975514, 28880538; Product type r: regulator" /codon_start=1 /transl_table=11 /product="stimulator of DhbF tyrosine adenylation activity" /protein_id="YP_003097779.1" /db_xref="EnsemblGenomes-Gn:BSU31959" /db_xref="EnsemblGenomes-Tr:CAX52685" /db_xref="InterPro:IPR005153" /db_xref="UniProtKB/Swiss-Prot:C0H3Q6" /translation="MANPFENADGTYLVLVNEEGQYSLWPGFIDVPSGWTVVHEQKGR EACLDYIQSHWSDMRPNSLKTVENV*" /label="mbtH CDS" gene complement(2713857..2714066) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /label="mbtH gene" downshifts complement(2713869) /Source="Nicolas_upshifts" /id="D1653" /incds=0 /nref=106 /ntot=174 /MaxReadThrough="1.39981" /MaxDrop="6.23998" /score="17.380299" /energy="-12" /TU="NA" /idTUdmin="U2496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2714082..2721218) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /EC_number="2.7.7.-" /EC_number="5.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11112781, 12354229, 16672620, 18957859, 26284661, 27731335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11112781, 12354229, 16672620, 18957859, 26284661, 27731335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase" /protein_id="NP_391076.3" /db_xref="EnsemblGenomes-Gn:BSU31960" /db_xref="EnsemblGenomes-Tr:CAB15186" /db_xref="GOA:P45745" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11243" /db_xref="UniProtKB/Swiss-Prot:P45745" /translation="MPDTKDLQYSLTGAQTGIWFAQQLDPDNPIYNTAEYIEINGPVN IALFEEALRHVIKEAESLHVRFGENMDGPWQMINPSPDVQLHVIDVSSEPDPEKTALN WMKADLAKPVDLGYAPLFNEALFIAGPDRFFWYQRIHHIAIDGFGFSLIAQRVASTYT ALIKGQTAKSRSFGSLQAILEEDTDYRGSEQYEKDRQFWLDRFADAPEVVSLADRAPR TSNSFLRHTAYLPPSDVNALKEAARYFSGSWHEVMIAVSAVYVHRMTGSEDVVLGLPM MGRIGSASLNVPAMVMNLLPLRLTVSSSMSFSELIQQISREIRSIRRHHKYRHEELRR DLKLIGENHRLFGPQINLMPFDYGLDFAGVRGTTHNLSAGPVDDLSINVYDRTDGSGL RIDVDANPEVYSESDIKLHQQRILQLLQTASAGEDMLIGQMELLLPEEKEKVISKWNE TAKSEKLVSLQDMFEKQAVLTPERIALMCDDIQVNYRKLNEEANRLARLLIEKGIGPE QFVALALPRSPEMVASMLGVLKTGAAYLPLDPEFPADRISYMLEDAKPSCIITTEEIA ASLPDDLAVPELVLDQAVTQEIIKRYSPENQDVSVSLDHPAYIIYTSGSTGRPKGVVV TQKSLSNFLLSMQEAFSLGEEDRLLAVTTVAFDISALELYLPLISGAQIVIAKKETIR EPQALAQMIENFDINIMQATPTLWHALVTSEPEKLRGLRVLVGGEALPSGLLQELQDL HCSVTNLYGPTETTIWSAAAFLEEGLKGVPPIGKPIWNTQVYVLDNGLQPVPPGVVGE LYIAGTGLARGYFHRPDLTAERFVADPYGPPGTRMYRTGDQARWRADGSLDYIGRADH QIKIRGFRIELGEIDAVLANHPHIEQAAVVVREDQPGDKRLAAYVVADAAIDTAELRR YMGASLPDYMVPSAFVEMDELPLTPNGKLDRKALPAPDFSTSVSDRAPRTPQEEILCD LFAEVLGLARVGIDDSFFELGGHSLLAARLMSRIREVMGAELGIAKLFDEPTVAGLAA HLDLAQSACPALQRAERPEKIPLSFAQRRLWFLHCLEGPSPTYNIPVAVRLSGELDQG LLKAALYDLVCRHESLRTIFPESQGTSYQHILDADRACPELHVTEIAEKELSDRLAEA VRYSFDLAAEPAFRAELFVIGPDEYVLLLLVHHIVGDGWSLTPLTRDLGTAYAARCHG RSPEWAPLAVQYADYALWQQELLGNEDDPNSLIAGQLAFWKETLKNLPDQLELPTDYS RPAEPSHDGDTIHFRIEPEFHKRLQELARANRVSLFMVLQSGLAALLTRLGAGTDIPI GSPIAGRNDDALGDLVGLFINTLVLRTDTSGDPSFRELLDRVREVNLAAYDNQDLPFE RLVEVLNPARSRATHPLFQIMLAFQNTPDAELHLPDMESSLRINSVGSAKFDLTLEIS EDRLADGTPNGMEGLLEYSTDLFKRETAQALADRLMRLLEAAESDPDEQIGNLDILAP EEHSSMVTDWQSVSEKIPHACLPEQFEKQAALRPDAIAVVYENQELSYAELNERANRL ARMMISEGVGPEQFVALALPRSLEMAVGLLAVLKAGAAYLPLDPDYPADRIAFMLKDA QPAFIMTNTKAANHIPPVENVPKIVLDDPELAEKLNTYPAGNPKNKDRTQPLSPLNTA YVIYTSGSTGVPKGVMIPHQNVTRLFAATEHWFRFSSGDIWTMFHSYAFDFSVWEIWG PLLHGGRLVIVPHHVSRSPEAFLRLLVKEGVTVLNQTPSAFYQFMQAEREQPDLGQAL SLRYVIFGGEALELSRLEDWYNRHPENRPQLINMYGITETTVHVSYIELDRSMAALRA NSLIGCGIPDLGVYVLDERLQPVPPGVAGELYVSGAGLARGYLGRPGLTSERFIADPF GPPGTRMYRTGDVARLRADGSLDYVGRADHQVKIRGFRIELGEIEAALVQHPQLEDAA VIVREDQPGDKRLAAYVIPSEETFDTAELRRYAAERLPDYMVPAAFVTMKELPLTPNG KLDRKALPAPDFAAAVTGRGPRTPQEEILCDLFMEVLHLPRVGIDDRFFDLGGHSLLA VQLMSRIREALGVELSIGNLFEAPTVAGLAERLEMGSSQSALDVLLPLRTSGDKPPLF CVHPAGGLSWCYAGLMTNIGTDYPIYGLQARGIGQREELPKTLDDMAADYIKQIRTVQ PKGPYHLLGWSLGGNVVQAMATQLQNQGEEVSLLVMLDAYPNHFLPIKEAPDDEEALI ALLALGGYDPDSLGEKPLDFEAAIEILRRDGSALASLDETVILNLKNTYVNSVGILGS YKPKTFRGNVLFFRSTIIPEWFDPIEPDSWKPYINGQIEQIDIDCRHKDLCQPEPLAQ IGKVLAVKLEELNK*" /label="dhbF CDS" gene complement(2714082..2721218) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /label="dhbF gene" CDS complement(2721238..2722176) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /EC_number="3.3.2.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismatase (siderophore specific)" /protein_id="NP_391077.1" /db_xref="EnsemblGenomes-Gn:BSU31970" /db_xref="EnsemblGenomes-Tr:CAB15187" /db_xref="GOA:P45743" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11241" /db_xref="UniProtKB/Swiss-Prot:P45743" /translation="MAIPAIQPYQMPTASDMPQNKVSWVPDPNRAVLLIHDMQNYFVD AFTAGASPVTELSANIRKLKNQCVQLGIPVVYTAQPGSQNPDDRALLTDFWGPGLNSG PYEEKIITELAPEDDDLVLTKWRYSAFKRTNLLEMMRKEGRDQLIITGIYAHIGCLVT ACEAFMEDIKAFFVGDAVADFSLEKHQMALEYAAGRCAFTVMTDSLLDQLQNAPADVQ KTSANTGKKNVFTCENIRKQIAELLQETPEDITDQEDLLDRGLDSVRIMTLVEQWRRE GAEVTFVELAERPTIEEWQKLLTTRSQQVLPNADYL*" /label="dhbB CDS" gene complement(2721238..2722176) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /label="dhbB gene" CDS complement(2722204..2723823) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /EC_number="2.7.7.58" /EC_number="6.3.2.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydroxybenzoate-AMP ligase" /protein_id="NP_391078.1" /db_xref="EnsemblGenomes-Gn:BSU31980" /db_xref="EnsemblGenomes-Tr:CAB15188" /db_xref="GOA:P40871" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR011963" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:1MD9" /db_xref="PDB:1MDB" /db_xref="PDB:1MDF" /db_xref="SubtiList:BG11020" /db_xref="UniProtKB/Swiss-Prot:P40871" /translation="MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAI TCGNTHWSYRELDTRADRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALP VFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEA EEFLPLEDLHAEPVKLPEVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVC WLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTIT ALVPPLAMVWMDAASSRRDDLSSLQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAE GLVNYTRLDDPEEIIVNTQGKPMSPYDEMRVWDDHDRDVKPGETGHLLTRGPYTIRGY YKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLL AHPAVHDAAMVSMPDQFLGERSCVFIIPRDEAPKAAELKAFLRERGLAAYKIPDRVEF VESFPQTGVGKVSKKALREAISEKLLAGFKK*" /label="dhbE CDS" gene complement(2722204..2723823) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /label="dhbE gene" CDS complement(2723852..2725048) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /EC_number="5.4.4.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12354229, 16672620, 19777807, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismate synthase (siderophore-specific)" /protein_id="NP_391079.2" /db_xref="EnsemblGenomes-Gn:BSU31990" /db_xref="EnsemblGenomes-Tr:CAB15189" /db_xref="GOA:P45744" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="SubtiList:BG11242" /db_xref="UniProtKB/Swiss-Prot:P45744" /translation="MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPE ADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVPFDQVKAARLVVPEEVRWSGPLQ FDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPI QTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAG SRPRSNDPVEDQRRAAELLSSAKDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTE TMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREAILSIEPFDRGFFTG MVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRA MGVDHI*" /label="dhbC CDS" gene complement(2723852..2725048) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /label="dhbC gene" promotor_-35 2724896..2724903 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2724918..2724937 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2724925 /Source="Nicolas_upshifts" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2725074..2725859) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /EC_number="1.3.1.28" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase" /protein_id="NP_391080.2" /db_xref="EnsemblGenomes-Gn:BSU32000" /db_xref="EnsemblGenomes-Tr:CAB15190" /db_xref="GOA:P39071" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR003560" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11019" /db_xref="UniProtKB/Swiss-Prot:P39071" /translation="MNAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEK LEKVVSSLKAEGRHAEAFPADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIH SLSDEEWEATFSVNSTGVFNASRSVSKYMMDRRSGSIVTVGSNAAGVPRTSMAAYASS KAAAVMFTKCLGLELAEYNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKT GIPLKKLAKPSDIADAVLFLVSGQAGHITMHNLCVDGGATLGV*" /label="dhbA CDS" gene complement(2725074..2725859) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /label="dhbA gene" S_feature complement(2725860..2725969) /Source="Nicolas_S_feature" /locus_tag="new_3292297_3292406_c" /HighExp="HiOs, GM 15, B60, nit, GM 10, GM 25, B36, GM 60, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1228" promotor_-10 complement(2725964..2725983) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2725969) /Source="Nicolas_upshifts" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2725971..2726052) /Source="Nicolas_S_feature" /locus_tag="new_3292408_3292489_c" /HighExp="HiOs, B60, nit, B36, GM 45, GM 10, BI, GM 15, GM 25, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1229" promotor_-35 complement(2725997..2726004) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2726053..2726922) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16889643, 19673474, 26284661, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillibactin trilactone hydrolase" /protein_id="NP_391081.2" /db_xref="EnsemblGenomes-Gn:BSU32010" /db_xref="EnsemblGenomes-Tr:CAB15191" /db_xref="GOA:O32102" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13974" /db_xref="UniProtKB/Swiss-Prot:O32102" /translation="MKEQTTDRTNGGTSNAFTIPGTEVRMMSSRNENRTYHIFISKPS TPPPPAGYPVIYLLDANSVFGTMTEAVRIQGRRPEKTGVIPAVIVGIGYETAEPFSSA RHRDFTMPTAQSKLPERPDGREWPEHGGAEGFFRFIEEDLKPEIERDYQIDKKRQTIF GHSLGGLFVLQVLLTKPDAFQTYIAGSPSIHWNKPFILKKTDHFVSLTKKNNQPINIL LAAGELEQHHKSRMNDNARELYERLAVLSEQGIRAEFCEFSGEGHISVLPVLVSRALR FALHPDGPHLSMG*" /label="besA CDS" gene complement(2726053..2726922) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /label="besA gene" S_feature complement(2726923..2727003) /Source="Nicolas_S_feature" /locus_tag="new_3293360_3293440_c" /HighExp="HiOs, B60, nit, GM 15, BI, B36, LoTm, T-5.40H, Lbexp, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1230" promotor_-10 complement(2726987..2727006) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2727003) /Source="Nicolas_upshifts" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2727020..2727027) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2727136..2727732) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /EC_number="1.7.3.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11598126, 16341843, 21190336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin containing enzyme subunit" /protein_id="NP_391082.1" /db_xref="EnsemblGenomes-Gn:BSU32020" /db_xref="EnsemblGenomes-Tr:CAB15192" /db_xref="GOA:O32103" /db_xref="InterPro:IPR000572" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13973" /db_xref="UniProtKB/Swiss-Prot:O32103" /translation="MYFGKTRQSDQSGRVPPNQNVTTSFPVLHTGDVPYYEDMTKWNL QVYGLVDHPMLLSFEDVKAFPRYESKNDIHCVTGWSRLDNVWQGVRACDIAEKAGVKE EAGYVILHAEEGWTTNLPLDDFLAETSLLAYAHNGEPLTPEHGFPLRGVFPHLYFWKS AKWLRGIQFTKENHPGFWERNGYHMRGDPWQNQRFTWD*" /label="yuiH CDS" gene complement(2727136..2727732) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /label="yuiH gene" S_feature complement(2727733..2727817) /Source="Nicolas_S_feature" /locus_tag="new_3294170_3294254_c" /HighExp="H2O2, Paraq, Cold, dia15, G135, B36, G180, B60, LoTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.204" /TUlongSig="NA" /TUlongPSig="NA" /label="S1231" promotor_-35 2727768..2727775 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2727785 /Source="Nicolas_upshifts" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2727790..2727809 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2727811..2727825) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2727817) /Source="Nicolas_upshifts" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2727833..2727837) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2727833..2728435 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717296, 15849754, 16850406, 24816803; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative biotin transporter" /protein_id="NP_391083.1" /db_xref="EnsemblGenomes-Gn:BSU32030" /db_xref="EnsemblGenomes-Tr:CAB15193" /db_xref="GOA:O32104" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13972" /db_xref="UniProtKB/Swiss-Prot:O32104" /translation="MKQRKLRAGDMALIGMFAALMAVGANITSVAPFLQVAGIPLSMQ PFFCLLAALLLGSKRAAIAMIVYALVGLAGAPVFAQFSAGFAPFAGKSGGFIISYIPA AFAAGWFLERNIQPSKIRFLIASLIGTAIMYLIGTTYMYLALKLWIHTPVSYGTAWGF MIWFMVKDTALAVILSFIAPAIYRSIHKATGFNRNHISST*" /label="bioYB CDS" gene 2727833..2728435 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /label="bioYB gene" downshifts 2728421 /Source="Nicolas_upshifts" /id="D1654" /incds=0 /nref=145 /ntot=206 /MaxReadThrough="3.24182" /MaxDrop="6.72885" /score="12.6395055" /energy="-6.3" /TU="U2498" /idTUdmin="U2498" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" CDS complement(2728505..2729833) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15135544, 15849754, 16850406, 23504016; Product type t : transporter" /codon_start=1 /transl_table=11 /product="histidine / basic amino acid transporter" /protein_id="NP_391084.1" /db_xref="EnsemblGenomes-Gn:BSU32040" /db_xref="EnsemblGenomes-Tr:CAB15194" /db_xref="GOA:O32105" /db_xref="InterPro:IPR018461" /db_xref="InterPro:IPR032813" /db_xref="SubtiList:BG13971" /db_xref="UniProtKB/Swiss-Prot:O32105" /translation="MNAVVIAVLLMLVLSLLRVNIVIALIIGALAGGLTGGLGLGETV KAFTDGLGGNATVAVSYAMLGAFAAALTKTGLPDAMVEASVKLIGNKEDSRKKALSKV LIVLIILIVSCFSQNVVPVHIAFIPVLIPPLLKIFNELEMDRRLIACVITFGLTAPYI LLPVGFGQIFQGMLKDNMADAGLNVPLADIPYALIIPVAGMVVGLILSVIVYRKPKQY ETKDISGAEASPYTRKSIGIAVLAIVVSLGVQLYLSQTLGVEGMIMGALAGLIVLFVS GVMKRDEADSLITDGMVLMAFIGFVMLVAAGFSNVLTKTGDVESLVKTSAGFIGHSQS LGALLMLIVGLLITMGIGSSFATIPVITTIFVPLCMQLGFSPMATIAIIGAAAALGDA GSPASDSTLGPTSGLSADGQHHHIWDTCVPTFIFYNIPLVIFGWIAALVL*" /label="hisP CDS" gene complement(2728505..2729833) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /label="hisP gene" downshifts complement(2728521) /Source="Nicolas_upshifts" /id="D1655" /incds=0 /nref=14 /ntot=114 /MaxReadThrough="4.26298" /MaxDrop="4.37949" /score="18.6861113" /energy="-15.4" /TU="U2500" /idTUdmin="U2500" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2729887..2729906) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2729890) /Source="Nicolas_upshifts" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2729921..2729928) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2729980..2731482) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /EC_number="3.4.11.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8057849, 9864319, 10449417, 26936797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytosol aminopeptidase" /protein_id="NP_391085.1" /db_xref="EnsemblGenomes-Gn:BSU32050" /db_xref="EnsemblGenomes-Tr:CAB15195" /db_xref="GOA:O32106" /db_xref="InterPro:IPR000819" /db_xref="InterPro:IPR008283" /db_xref="InterPro:IPR011356" /db_xref="InterPro:IPR023042" /db_xref="SubtiList:BG13970" /db_xref="UniProtKB/Swiss-Prot:O32106" /translation="MFYAVQQSEHTETLVVGLFQKSQLTGKALEIDEMLEGHLTQLLK EGDVSAKPNQVSKVFPPSSAGMKRIYFVGLGREANYSFEQAKERFAHVFQAIHKDRKQ ETAVLLDTFISEDVPPADAAHALAESCLLASYEVQDYKHKSNEPDKQIEAVYVVTDED TQEVQAGLRVGQAYGQGTNSARTLVNMPGNMLTATDLASYAEELAAKYDFECEILEKS EMEELGMGGILAVNQGSTEPPKMIVLKYQGKKEWEDVVGLVGKGITFDTGGYSIKTKS GIVGMKSDMGGAAAVLGAMETIGELRPEQNVLCVIPSTDNMISGGAMKPDDVIVSLSG KTIEILNTDAEGRLVLADGITYAKQHGASVLVDVATLTGGVVVALGTETTGAMTNDQS FYQQVADAAQECGEAIWQLPITEKDKKRVKSSQMADLSNSPGREGHAIMAGTFLGEFA ESTPWVHLDIAGTATANKATCFGPAGATGVMARTLATLAERFTLEEDKNE*" /label="pepA CDS" gene complement(2729980..2731482) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /label="pepA gene" downshifts complement(2729995) /Source="Nicolas_upshifts" /id="D1656" /incds=0 /nref=149 /ntot=220 /MaxReadThrough="4.44151" /MaxDrop="5.59726" /score="31.6277104" /energy="-16" /TU="NA" /idTUdmin="U2503" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2731047..2731061 /Source="Nicolas_upshift_promotors" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2731063 /Source="Nicolas_upshifts" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2731483..2731557) /Source="Nicolas_S_feature" /locus_tag="new_3297920_3297994_c" /HighExp="M40t90, Lbtran, LBGtran, Lbstat, C90, M0t90, T1.0H, LoTm, M40t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1232" promotor_-35 2731505..2731512 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2731523..2731542 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2731525..2731639 /Source="Nicolas_S_feature" /locus_tag="new_3297962_3298076" /HighExp="Etha, Cold, Gly, Sw, LoTm, BC, B60, C90, dia5, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1233" upshifts 2731525 /Source="Nicolas_upshifts" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2731552..2731571) /Source="Nicolas_upshift_promotors" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2731562) /Source="Nicolas_upshifts" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="upshifts" CDS 2731640..2732116 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391086.1" /db_xref="EnsemblGenomes-Gn:BSU32060" /db_xref="EnsemblGenomes-Tr:CAB15196" /db_xref="GOA:O32107" /db_xref="InterPro:IPR003832" /db_xref="SubtiList:BG13969" /db_xref="UniProtKB/Swiss-Prot:O32107" /translation="MELLTNFPLLSSLAAIIFAQVIKVPIQFIVSRKLDWSLVTSTGG MPSSHSAAVTALSTGVALEHGLDSSLFAVSAIFAVITMFDATGVRRHAGEQATVINKL VIDFNRFVNEAKDFPKAAEKEKQKKLKELLGHQPIEVFFGGLTGILLTLVLAYFFM*" /label="yuiD CDS" gene 2731640..2732116 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /label="yuiD gene" downshifts 2732065 /Source="Nicolas_upshifts" /id="D1657" /incds=0 /nref=18 /ntot=174 /MaxReadThrough="3.22946" /MaxDrop="3.90704" /score="10.9647804" /energy="-11.6" /TU="U2502" /idTUdmin="U2502" /TUdmin="-208" /isTUend="FALSE" /label="downshifts" CDS complement(2732147..2732803) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /experiment="publication(s) with functional evidences, PMID:26163297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26163297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stationary phase survival protein" /protein_id="NP_391087.1" /db_xref="EnsemblGenomes-Gn:BSU32070" /db_xref="EnsemblGenomes-Tr:CAB15197" /db_xref="GOA:O32108" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR036908" /db_xref="PDB:4WJT" /db_xref="PDB:4WLI" /db_xref="PDB:4WLK" /db_xref="SubtiList:BG13968" /db_xref="UniProtKB/Swiss-Prot:O32108" /translation="MMLNMIRRLLMTCLFLLAFGTTFLSVSGIEAKDLSKWVQEHQEK HLKHAGLRLKALQQKQTQTTSAAEDKTKPLEEAFDWDEYPVQRVTATGYTAGAESTGK NPGDPLYGLTYSGVKVKRDLYSTVAADPSVFPIGTILFIPNYGLGVVADTGSAIKGNR LDLYFETVKDVYNEWGKKTLDVYVIKKGTGKITEDELEKLNETKSLQVFRNQYKTVKE *" /label="spsC CDS" gene complement(2732147..2732803) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /label="spsC gene" downshifts complement(2732175) /Source="Nicolas_upshifts" /id="D1658" /incds=0 /nref=178 /ntot=253 /MaxReadThrough="0.714039999999999" /MaxDrop="6.31907" /score="33.0538307" /energy="-12.6" /TU="NA" /idTUdmin="U2505" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2732451..2732460 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2732474..2732493 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2732491 /Source="Nicolas_upshifts" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="upshifts" S_feature 2732493..2732939 /Source="Nicolas_S_feature" /locus_tag="new_3298930_3299376" /HighExp="S6, S8, S7, BT, B36, G/S, S5, Pyr, Cold, B60" /AntisenseName="yuiC" /AntisenseCor="0.52395204592174105" /AntisenseRegPval="-19.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1234" upshifts complement(2732817) /Source="Nicolas_upshifts" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2732819..2732830) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2732845..2732851) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2732896 /Source="Nicolas_upshifts" /id="D1659" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="7.61734" /MaxDrop="4.9382" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin="-323" /isTUend="FALSE" /label="downshifts" CDS complement(2732907..2733227) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391088.1" /db_xref="EnsemblGenomes-Gn:BSU32080" /db_xref="EnsemblGenomes-Tr:CAB15198" /db_xref="GOA:O32109" /db_xref="InterPro:IPR025917" /db_xref="SubtiList:BG13967" /db_xref="UniProtKB/Swiss-Prot:O32109" /translation="MISLPVVIISIVLFFVLFFGIGFLLNMLLRMSWIMAVIYPIVCL FIISKEKLISYVQSPGESFASLFHRVLSLAAADVLILVSGLAGAIVSGIAINMLRKRG YQMF*" /label="yuiB CDS" gene complement(2732907..2733227) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /label="yuiB gene" downshifts complement(2732921) /Source="Nicolas_upshifts" /id="D1660" /incds=0 /nref=151 /ntot=218 /MaxReadThrough="4.24535" /MaxDrop="5.6597" /score="13.4559443" /energy="-7.6" /TU="U2507,U2508" /idTUdmin="U2510" /TUdmin=660 /isTUend="FALSE" /label="downshifts" S_feature 2732941..2733151 /Source="Nicolas_S_feature" /locus_tag="new_3299378_3299588" /HighExp="S8, S6, S7, BT, Cold, Gly, H2O2, G/S, C30, G180" /AntisenseName="yuiB" /AntisenseCor="-0.11290507783715401" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1235" promotor_no_box 2733093..2733193 /Source="Nicolas_upshift_promotors" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2733153..2733262 /Source="Nicolas_S_feature" /locus_tag="new_3299590_3299699" /HighExp="S8, S6, BT, S7, Sw, Gly, G180, BC, Diami, H2O2" /AntisenseName="yuiB" /AntisenseCor="-7.7565560595235006E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.03, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1236" upshifts 2733153 /Source="Nicolas_upshifts" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="upshifts" downshifts 2733219 /Source="Nicolas_upshifts" /id="D1661" /incds=0 /nref=10 /ntot=28 /MaxReadThrough="3.79664" /MaxDrop="6.06021" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2733246..2733265) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2733251) /Source="Nicolas_upshifts" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" S_feature 2733264..2733815 /Source="Nicolas_S_feature" /locus_tag="new_3299701_3300252" /HighExp="S6, S8, S7, Cold, H2O2, BC, Sw, Pyr, BT, C30" /AntisenseName="yuiA" /AntisenseCor="5.87811391089679E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1237" promotor_-35 complement(2733280..2733287) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2733281..2733424) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391089.1" /db_xref="EnsemblGenomes-Gn:BSU32090" /db_xref="EnsemblGenomes-Tr:CAB15199" /db_xref="InterPro:IPR035272" /db_xref="InterPro:IPR036410" /db_xref="SubtiList:BG12389" /db_xref="UniProtKB/Swiss-Prot:O32110" /translation="MKTATTTASHACPFCSGKGYFQLILGGSETCPSCQGTGKDSHSF SSR*" /label="yuiA CDS" gene complement(2733281..2733424) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /label="yuiA gene" promotor_-10 complement(2733448..2733467) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2733469) /Source="Nicolas_upshifts" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2733483..2733486) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2733597..2734817) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 17015645, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-disulfide oxidoreductase" /protein_id="NP_391090.1" /db_xref="EnsemblGenomes-Gn:BSU32100" /db_xref="EnsemblGenomes-Tr:CAB15200" /db_xref="GOA:O05267" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12390" /db_xref="UniProtKB/Swiss-Prot:O05267" /translation="MALNKPKIVILGAGYGGLMTVTRLTKYVGPNDADITLVNKHNYH YETTWMHEASAGTLHHDRCRYQIKDVINQSRVNFVQDTVKAIKIDEKKVVLANGELQY DYLVIGLGAVPETFGIKGLKEYAFPIANINTSRLLREHIELQFATYNTEAEKRPDRLT IVVGGAGFTGIEFLGELAARVPELCKEYDVDRSLVRIICVEAAPTVLPGFDPELVDYA VHYLEENGVEFKIGTAVQECTPEGVRVGKKDEEPEQIKSQTVVWAAGVRGHPIVEEAG FENMRGRVKVNPDLRAPGHDNVFILGDSSLFMNEDTERPYPPTAQIAMQQGITVAKNL GRLIKGGELEEFKPDIKGTVASLGEHNAVGVVYGRKLKGTPASFMKKVIDNRSLFMIG GLGLTLKKGKFKFF*" /label="yumB CDS" gene complement(2733597..2734817) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /label="yumB gene" downshifts complement(2733625) /Source="Nicolas_upshifts" /id="D1662" /incds=0 /nref=15 /ntot=123 /MaxReadThrough="3.19525" /MaxDrop="3.6794" /score="23.523765" /energy="-8.9" /TU="U2510" /idTUdmin="U2509" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2734818..2734945) /Source="Nicolas_S_feature" /locus_tag="new_3301255_3301382_c" /HighExp="Salt, S4, Etha, S5, S3, S7, S6, LoTm, B36, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.752, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1238" upshifts complement(2734945) /Source="Nicolas_upshifts" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2734947..2735011) /Source="Nicolas_S_feature" /locus_tag="new_3301384_3301448_c" /HighExp="Salt, Etha, Heat, BMM, BC, H2O2, Paraq, C30, Sw, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1239" promotor_-10 complement(2734947..2734965) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2734981..2734986) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2735002..2735021) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2735010) /Source="Nicolas_upshifts" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2735036..2735043) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2735085..2735092 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2735104..2735123 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2735104 /Source="Nicolas_upshifts" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="upshifts" CDS 2735149..2736147 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /EC_number="1.18.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15252706, 22938038, 26507228, 26965753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 22938038, 26507228, 26965753; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferredoxin-NADP+ reductase (flavodoxin)" /protein_id="NP_391091.2" /db_xref="EnsemblGenomes-Gn:BSU32110" /db_xref="EnsemblGenomes-Tr:CAB15201" /db_xref="GOA:O05268" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="PDB:3LZW" /db_xref="PDB:3LZX" /db_xref="SubtiList:BG12391" /db_xref="UniProtKB/Swiss-Prot:O05268" /translation="MREDTKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGG QLSALYPEKYIYDVAGFPKIRAQELINNLKEQMAKFDQTICLEQAVESVEKQADGVFK LVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVDDLQKFAGRRVAIL GGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHASKVNVLTPFVPAELIGE DKIEQLVLEEVKGDRKEILEIDDLIVNYGFVSSLGPIKNWGLDIEKNSIVVKSTMETN IEGFFAAGDICTYEGKVNLIASGFGEAPTAVNNAKAYMDPKARVQPLHSTSLFENK*" /label="trxBB CDS" gene 2735149..2736147 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /label="trxBB gene" promotor_-10 complement(2735172..2735190) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2735187) /Source="Nicolas_upshifts" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2735207..2735212) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2736123 /Source="Nicolas_upshifts" /id="D1663" /incds=0 /nref=162 /ntot=262 /MaxReadThrough="0.70088" /MaxDrop="7.47867" /score="21.6819221" /energy="-12.8" /TU="U2511" /idTUdmin="U2511" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2736186..2736326) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein or unknown function" /protein_id="NP_391092.1" /db_xref="EnsemblGenomes-Gn:BSU32120" /db_xref="EnsemblGenomes-Tr:CAB15202" /db_xref="GOA:O32111" /db_xref="SubtiList:BG14056" /db_xref="UniProtKB/Swiss-Prot:O32111" /translation="MAQNEEKTPKSQKIQDRIIMAMIWVVAALVIALVVGTALNYINI FK*" /label="yuzG CDS" gene complement(2736186..2736326) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /label="yuzG gene" downshifts complement(2736198) /Source="Nicolas_upshifts" /id="D1664" /incds=0 /nref=61 /ntot=234 /MaxReadThrough="1.27572" /MaxDrop="5.65243" /score="32.0354025" /energy="-12.8" /TU="NA" /idTUdmin="U2515" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(2736327..2736456) /Source="Nicolas_S_feature" /locus_tag="new_3302764_3302893_c" /HighExp="dia15, Salt, Cold, Diami, H2O2, Etha, GM 15, dia5, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.36371900000000001" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1240" promotor_-10 complement(2736437..2736456) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2736456) /Source="Nicolas_upshifts" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2736458..2736705) /Source="Nicolas_S_feature" /locus_tag="new_3302895_3303142_c" /HighExp="S8, S5, S6, S7, S4, ferm, nit, C30, Pyr, T5.0H" /AntisenseName="guaC" /AntisenseCor="-0.291283195124732" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1241" promotor_-35 complement(2736470..2736476) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2736513..2736520 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2736534..2736553 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2736542 /Source="Nicolas_upshifts" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2736605..2737585 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /EC_number="1.7.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 11591660, 6408059" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 11591660, 6408059; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP reductase (NADP-dependent)" /protein_id="NP_391093.2" /db_xref="EnsemblGenomes-Gn:BSU32130" /db_xref="EnsemblGenomes-Tr:CAB15203" /db_xref="GOA:O05269" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005994" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG12392" /db_xref="UniProtKB/Swiss-Prot:O05269" /translation="MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPAN MQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKDMNARGLFSSISVGVKDEEYEFV RQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENA GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAK SIRFGATMVMIGSLFAGHEESPGQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHV AHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSIFNGDKY*" /label="guaC CDS" gene 2736605..2737585 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /label="guaC gene" upshifts complement(2736706) /Source="Nicolas_upshifts" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2736710..2736721) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2736735..2736741) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2737553 /Source="Nicolas_upshifts" /id="D1665" /incds=0 /nref=91 /ntot=186 /MaxReadThrough="1.24882" /MaxDrop="7.43286" /score="-2.82053244" /energy="-16.2" /TU="NA" /idTUdmin="U2514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2737658) /Source="Nicolas_upshifts" /id="D1666" /incds=0 /nref=24 /ntot=212 /MaxReadThrough="1.15696" /MaxDrop="6.12198" /score="23.834956" /energy="-16.2" /TU="NA" /idTUdmin="U2517" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2737659..2738282) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16210326, 21633969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates paiA expression)" /protein_id="NP_391094.2" /db_xref="EnsemblGenomes-Gn:BSU32140" /db_xref="EnsemblGenomes-Tr:CAB15204" /db_xref="GOA:P21341" /db_xref="InterPro:IPR007396" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG10696" /db_xref="UniProtKB/Swiss-Prot:P21341" /translation="MYIPKYFKVTNAEEIWNFVQENSFGTVVTTEQGKPIATHLPLGF NKKDDHYYITGHFAYGNPQWRTFEACEDVLVMFQGPHAYISSSWYSRENVPTWNYQAV HMYGKASMLEKDELAEELTIMLEKYEKHRDNPVLWDKLSPKLLESELKGIVGFKIKVE DIQAAYKLSQNRNETDYMNVIEQLQNEENPNAKQMAELMEDKLKKQI*" /label="paiB CDS" gene complement(2737659..2738282) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /label="paiB gene" CDS complement(2738306..2738824) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /EC_number="2.3.1.57" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16210326, 17588214, 21633970, 26818562, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16210326, 17588214, 21633970, 26818562, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyamine N-acetyltransferase" /protein_id="NP_391095.1" /db_xref="EnsemblGenomes-Gn:BSU32150" /db_xref="EnsemblGenomes-Tr:CAB15205" /db_xref="GOA:P21340" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1TIQ" /db_xref="SubtiList:BG10695" /db_xref="UniProtKB/Swiss-Prot:P21340" /translation="MSVKMKKCSREDLQTLQQLSIETFNDTFKEQNSPENMKAYLESA FNTEQLEKELSNMSSQFFFIYFDHEIAGYVKVNIDDAQSEEMGAESLEIERIYIKNSF QKHGLGKHLLNKAIEIALERNKKNIWLGVWEKNENAIAFYKKMGFVQTGAHSFYMGDE EQTDLIMAKTLI*" /label="paiA CDS" gene complement(2738306..2738824) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /label="paiA gene" misc_feature complement(2738871..2738890) /Source="Nicolas_upshift_promotors" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2738883) /Source="Nicolas_upshifts" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2738885..2738993) /Source="Nicolas_S_feature" /locus_tag="new_3305322_3305430_c" /HighExp="LoTm, HiTm, G135, Salt, G180, Cold, LBGstat, T0.0H, B36, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1242" promotor_-10 complement(2738980..2738997) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2738991) /Source="Nicolas_upshifts" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2739012..2739019) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2739147) /Source="Nicolas_upshifts" /id="D1667" /incds=0 /nref=267 /ntot=269 /MaxReadThrough="1.56881" /MaxDrop="8.24828" /score="12.6937405" /energy="-18.7" /TU="NA" /idTUdmin="U2518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2739162..2739524) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17698959, 19478995, 20097860, 25447545; Product type c: carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier chaperone involved in Fe-S cluster assembly" /protein_id="NP_391096.1" /db_xref="EnsemblGenomes-Gn:BSU32160" /db_xref="EnsemblGenomes-Tr:CAB15206" /db_xref="GOA:O32113" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR016092" /db_xref="InterPro:IPR017870" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG14049" /db_xref="UniProtKB/Swiss-Prot:O32113" /translation="MSNPVTITEAAALHIKDMMKEHEEENAFLRVGVKGGGCSGLSYG MGFEHEKSESDSVFDQHGITVLVDKESLDIMNGTVIDYKQSMLGGGFTIDNPNAIASC GCGSSFRTATNAGKPEEC*" /label="sufA CDS" gene complement(2739162..2739524) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /label="sufA gene" promotor_-10 complement(2739555..2739574) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2739565) /Source="Nicolas_upshifts" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2739588..2739595) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2739603..2740457) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /EC_number="5.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 14627808, 16723397, 19307721, 28873470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diaminopimelate epimerase" /protein_id="NP_391097.1" /db_xref="EnsemblGenomes-Gn:BSU32170" /db_xref="EnsemblGenomes-Tr:CAB15207" /db_xref="GOA:O32114" /db_xref="InterPro:IPR001653" /db_xref="InterPro:IPR018510" /db_xref="SubtiList:BG14048" /db_xref="UniProtKB/Swiss-Prot:O32114" /translation="MNSFRFTKMHGLGNSYIYVNQFEEQLPEEKLSEIAIQVSSVYTG IGSDGMILICPSDQAPVKMRIFNNDGSEGKNCGNGLRCVAKYAYEHKLVEETSFLIET LSGLVKAEVQVENGKVNVVTVDMGEPRLTKSELPMLDGGEEHTINETMAFGEVELTGT AVSMGNPHIVFPIADIEQAPLTTLGPVIEKDPRFPEGINVEFVETVNEQELHFRVWER GSGITQACGTGACAAAVASVLNGVSKRNQDITVHLAGGDLVINWKDNGHVMMTGPAET VCEGVYFL*" /label="dapF CDS" gene complement(2739603..2740457) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /label="dapF gene" promotor_-10 complement(2740173..2740192) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2740181) /Source="Nicolas_upshifts" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2740205..2740214) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2740479..2740498) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2740493) /Source="Nicolas_upshifts" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2740513..2740516) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2740580..2741794) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+(H+)/nucleoside cotransporter" /protein_id="NP_391098.1" /db_xref="EnsemblGenomes-Gn:BSU32180" /db_xref="EnsemblGenomes-Tr:CAB15208" /db_xref="GOA:O32115" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG14047" /db_xref="UniProtKB/Swiss-Prot:O32115" /translation="MNVLWGLLGAVAIIAIAFLFSEKKSNIKIRTVIVGLCTQVAFGY IVLKWEAGRAVFLWFSSRVQLLIDYANEGISFIFGPLLKVGDSPAFALSVLPVIIFFS ALIAVLYHLKIMQLVFRVIGGGLSKLLGTSKTESLAAAANIFVGQSESPLVIKPLIAG LTRSELFTIMTSGLSAVAGSTLFGYALLGIPIEYLLAASFMAAPAGLVFGKLIIPETE KTQTVKSDFKMDEGEGAANVIDAAAKGASTGLQIALNVGAMLLAFVALIAVVNGILGG AFGLFGLKGVTLESILGYVFSPIAFLIGVPWHEALQAGSYIGQKLVLNEFVAYSNFGS HIGEFSKKTATIISFALCGFANFSSIAIMLGTLGGLAPSRRSDIARLGLKAVLAGTLA NLLSAAIAGMFI*" /label="yutK CDS" gene complement(2740580..2741794) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /label="yutK gene" promotor_-35 2741129..2741135 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2741150..2741168 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2741157 /Source="Nicolas_upshifts" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="upshifts" S_feature 2741161..2741930 /Source="Nicolas_S_feature" /locus_tag="new_3307598_3308367" /HighExp="Etha, Salt, Gly, M9-stat, Sw, LoTm, B60, BC, Heat, S0" /AntisenseName="yutK" /AntisenseCor="-0.36240965013078302" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1243" promotor_-10 complement(2741831..2741850) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-10" upshifts complement(2741836) /Source="Nicolas_upshifts" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="upshifts" promotor_-35 complement(2741865..2741872) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-35" downshifts 2741887 /Source="Nicolas_upshifts" /id="D1668" /incds=0 /nref=3 /ntot=58 /MaxReadThrough="4.13852" /MaxDrop="3.94079" /score="20.5760616" /energy="-10.5" /TU="U2521" /idTUdmin="U2521" /TUdmin="-1913" /isTUend="FALSE" /label="downshifts" CDS complement(2741931..2742167) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391099.1" /db_xref="EnsemblGenomes-Gn:BSU32190" /db_xref="EnsemblGenomes-Tr:CAB15209" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR022916" /db_xref="SubtiList:BG14051" /db_xref="UniProtKB/Swiss-Prot:O32116" /translation="MNPMIEFCVSNLAHGSQEARAILEKDPNLDVLEYGCLSYCGTCM ESLFALVNGEVVMGETPAELVENIYTFIEENPMF*" /label="yuzB CDS" gene complement(2741931..2742167) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /label="yuzB gene" S_feature 2741932..2742348 /Source="Nicolas_S_feature" /locus_tag="new_3308369_3308785" /HighExp="Salt, LoTm, Gly, Etha, Sw, Heat, S0, C30, M9-stat, Mal" /AntisenseName="yuzB" /AntisenseCor="-5.6824456709843603E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1244" downshifts complement(2741949) /Source="Nicolas_upshifts" /id="D1669" /incds=0 /nref=175 /ntot=239 /MaxReadThrough="1.28789" /MaxDrop="7.32368" /score="41.4640292" /energy="-10.5" /TU="NA" /idTUdmin="U2523" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2742132..2742133) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2742137..2742141) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2742139) /Source="Nicolas_upshifts" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2742182..2742201) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2742183) /Source="Nicolas_upshifts" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2742215..2742222) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2742325..2742330 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2742344..2742363 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2742350 /Source="Nicolas_upshifts" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="upshifts" CDS 2742430..2743497 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /EC_number="1.6.-.-" /function="16.10: Respire" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17015645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH dehydrogenase" /protein_id="NP_391100.2" /db_xref="EnsemblGenomes-Gn:BSU32200" /db_xref="EnsemblGenomes-Tr:CAB15210" /db_xref="GOA:O32117" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14046" /db_xref="UniProtKB/Swiss-Prot:O32117" /translation="MKKLVLIGGGYGNMRVLHRLLPNQLPDDVSITLIDRNPYHCLKT EYYALAAGTISDHHIRVSFPEHPRLDVQYGDITSIDIVQKQVLFQDREPISYDDAIIG LGCEDKYHNVPGAPEFTYSIQTIDQSRETYQKLNNLSANATVAIVGAGLSGVELASEL RESRDDLNIILFDRGNLILSSFPERLSKYVQKWFEEHGVRIINRANITKVEEGVVYNH DDPISADAIVWTAGIQPNKVVRDLDVEKDAQGRIVLTPHHNLPGDEHLYVVGDCASLP HAPSAQLAEAQAEQIVQILQKRWNGEALPESMPQFKLKGVLGSLGKKAGFGLVADRPL IGRVPRMLKSGLLWMYKHHNG*" /label="yutJ CDS" gene 2742430..2743497 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /label="yutJ gene" downshifts 2743481 /Source="Nicolas_upshifts" /id="D1670" /incds=0 /nref=4 /ntot=110 /MaxReadThrough="3.51945" /MaxDrop="3.02708" /score="6.15657679" /energy="-10.8" /TU="U2521,U2525" /idTUdmin="U2521" /TUdmin="-319" /isTUend="FALSE" /label="downshifts" CDS complement(2743523..2743849) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11551182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reduction management enzyme" /protein_id="NP_391101.1" /db_xref="EnsemblGenomes-Gn:BSU32210" /db_xref="EnsemblGenomes-Tr:CAB15211" /db_xref="InterPro:IPR009190" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14053" /db_xref="UniProtKB/Swiss-Prot:O32118" /translation="MMKPVMLSVYGAENVCASCVNMPTAKDTYEWLEAALKRKYPNQP FEMQYIDIHEPPDNEHAKELAEKIRNDEYFYPLVLVEDKIVGEGNPKLKDVYEEMEKH GYTENR*" /label="yuzD CDS" gene complement(2743523..2743849) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /label="yuzD gene" downshifts complement(2743546) /Source="Nicolas_upshifts" /id="D1671" /incds=0 /nref=4 /ntot=180 /MaxReadThrough="1.63835" /MaxDrop="3.17377" /score="-8.05690984" /energy="-10.8" /TU="NA" /idTUdmin="U2526" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2743881..2743900) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2743898) /Source="Nicolas_upshifts" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2743913..2743920) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2743933..2743937 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2743949..2744284 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17237162, 21749987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative iron-sulfur scaffold protein" /protein_id="NP_391102.1" /db_xref="EnsemblGenomes-Gn:BSU32220" /db_xref="EnsemblGenomes-Tr:CAB15212" /db_xref="GOA:O32119" /db_xref="InterPro:IPR001075" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG14045" /db_xref="UniProtKB/Swiss-Prot:O32119" /translation="MCYNRESNFANQTIDFYCYTEYNGFMTTKGANVMTEVEMKEQVQ EVLDKLRPFLLRDGGDCELVDVDEGIVKLRLLGACGSCPSSTITLKAGIERALLEEVP GVVEVEQVF*" /label="yutI CDS" gene 2743949..2744284 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /label="yutI gene" promotor_-10 2743950..2743969 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2743955 /Source="Nicolas_upshifts" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2744074) /Source="Nicolas_upshifts" /id="D1672" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="1.28655" /MaxDrop="3.45909" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2744262 /Source="Nicolas_upshifts" /id="D1673" /incds=0 /nref=258 /ntot=281 /MaxReadThrough="3.6035" /MaxDrop="7.98922" /score="39.7008566" /energy="-19.5" /TU="U2527" /idTUdmin="U2527" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(2744326..2746299) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8576092, 11406580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acylaminoacyl-peptidase" /protein_id="NP_391103.2" /db_xref="EnsemblGenomes-Gn:BSU32230" /db_xref="EnsemblGenomes-Tr:CAB15213" /db_xref="GOA:P39839" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10463" /db_xref="UniProtKB/Swiss-Prot:P39839" /translation="MKKLITADDITAIVSVTDPQYAPDGTRAAYVKSQVNQEKDSYTS NIWIYETKTGGSVPWTHGEKRSTDPRWSPDGRTLAFISDREGDAAQLYIMSTEGGEAR KLTDIPYGVSKPLWSPDGESILVTVSLGEGESIDDREKTEQDSYEPVEVQGLSYKRDG KGLTRGAYAQLVLVSVKSGEMKELTSHKADHGDPAFSPDGKWLVFSANLTETDDASKP HDVYIMSLESGDLKQVTPHRGSFGSSSFSPDGRYLALLGNEKEYKNATLSKAWLYDIE QGRLTCLTEMLDVHLADALIGDSLIGGAEQRPIWTKDSQGFYVIGTDQGSTGIYYISI EGLVYPIRLEKEYINSFSLSPDEQHFIASVTKPDRPSELYSIPLGQEEKQLTGANDKF VREHTISIPEEIQYATEDGVMVNGWLMRPAQMEGETTYPLILNIHGGPHMMYGHTYFH EFQVLAAKGYAVVYINPRGSHGYGQEFVNAVRGDYGGKDYDDVMQAVDEAIKRDPHID PKRLGVTGGSYGGFMTNWIVGQTNRFKAAVTQRSISNWISFHGVSDIGYFFTDWQLEH DMFEDTEKLWDRSPLKYAANVETPLLILHGERDDRCPIEQAEQLFIALKKMGKETKLV RFPNASHNLSRTGHPRQRIKRLNYISSWFDQHL*" /label="yuxL CDS" gene complement(2744326..2746299) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /label="yuxL gene" downshifts complement(2744338) /Source="Nicolas_upshifts" /id="D1674" /incds=0 /nref=19 /ntot=114 /MaxReadThrough="1.79797" /MaxDrop="3.85507" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2746314..2746332) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2746337) /Source="Nicolas_upshifts" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2746344..2746352) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2746407..2747336) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /EC_number="2.7.1.39" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine kinase" /protein_id="NP_391104.1" /db_xref="EnsemblGenomes-Gn:BSU32240" /db_xref="EnsemblGenomes-Tr:CAB15214" /db_xref="GOA:P04948" /db_xref="InterPro:IPR000870" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10462" /db_xref="UniProtKB/Swiss-Prot:P04948" /translation="MNEADMLFSVTVPGSTANLGPGFDSVGMALSRYLKLTVFESDKW SFEAETETVAGIPAGTDNLIYQVAKRTADLYGKEMPPVHVKVWSDIPLARGLGSSAAA IVAAIELADELCGLKLSEADKLHLASLEEGHPDNAGASLVGGLVIGLHEDDETQMIRV PNADIDVVVVIPFYEVLTRDARDVLPKEFPYADAVKASAVSNILIAAIMSKDWPLVGK IMKKDMFHQPYRAMLVPELSKVEHVAEMKGAYGTALSGAGPTILVMTEKGKGEELKEQ LALHFPHCEVDALTVPKEGSIIERNPLYQVKSV*" /label="thrB CDS" gene complement(2746407..2747336) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /label="thrB gene" downshifts complement(2746420) /Source="Nicolas_upshifts" /id="D1675" /incds=0 /nref=222 /ntot=261 /MaxReadThrough="2.39521" /MaxDrop="7.03759" /score="15.5945196" /energy="-10.3" /TU="NA" /idTUdmin="U2530" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2747333..2748391) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /EC_number="4.2.3.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 3139660, 8768250" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 3139660, 8768250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine synthase" /protein_id="NP_391105.1" /db_xref="EnsemblGenomes-Gn:BSU32250" /db_xref="EnsemblGenomes-Tr:CAB15215" /db_xref="GOA:P04990" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR004450" /db_xref="InterPro:IPR026260" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10461" /db_xref="UniProtKB/Swiss-Prot:P04990" /translation="MWKGLIHQYKEFLPVTDQTPALTLHEGNTPLIHLPKLSEQLGIE LHVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCI VIIPNGKIAFGKLAQAVMYGAEIIAIDGNFDDALKIVRSICEKSPIALVNSVNPYRIE GQKTAAFEVCEQLGEAPDVLAIPVGNAGNITAYWKGFKEYHEKNGTGLPKMRGFEAEG AAAIVRNEVIENPETIATAIRIGNPASWDKAVKAAEESNGKIDEVTDDEILHAYQLIA RVEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVAVLTGNGLKDPNTAVDISEIKPVT LPTDEDSILEYVKGAARV*" /label="thrC CDS" gene complement(2747333..2748391) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /label="thrC gene" CDS complement(2748391..2749692) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /EC_number="1.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3139660, 27299409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3139660, 27299409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine dehydrogenase" /protein_id="NP_391106.1" /db_xref="EnsemblGenomes-Gn:BSU32260" /db_xref="EnsemblGenomes-Tr:CAB15216" /db_xref="GOA:P19582" /db_xref="InterPro:IPR001342" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005106" /db_xref="InterPro:IPR016204" /db_xref="InterPro:IPR019811" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10460" /db_xref="UniProtKB/Swiss-Prot:P19582" /translation="MKAIRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLV KDLEKKREVDLPKEVLTTEVYDVIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVT ANKDLMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNG TTNFILTKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNV DLEDVKVKGISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSA VHNEFNAVYVYGEAVGETMFYGPGAGSMPTATSVVSDLVAVMKNMRLGVTGNSFVGPQ YEKNMKSPSDIYAQQFLRIHVKDEVGSFSKITSVFSERGVSFEKILQLPIKGHDELAE IVIVTHHTSEADFSDILQNLNDLEVVQEVKSTYRVEGNGWS*" /label="hom CDS" gene complement(2748391..2749692) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /label="hom gene" promotor_-35 2749577..2749586 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2749601..2749620 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2749608 /Source="Nicolas_upshifts" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2749693..2749774) /Source="Nicolas_S_feature" /locus_tag="new_3316130_3316211_c" /HighExp="T3.0H, T2.30H, T3.30H, S2, C90, T4.0H, BMM, SMM, MG 120, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1245" promotor_-10 complement(2749759..2749778) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2749774) /Source="Nicolas_upshifts" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2749776..2749892) /Source="Nicolas_S_feature" /locus_tag="new_3316213_3316329_c" /HighExp="S5, S3, S4, S7, S6, S8, BT, B36, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1246" promotor_-35 complement(2749793..2749800) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2749893..2750912) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /function="16.3: Control" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15231775, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat-associated protein" /protein_id="NP_391107.1" /db_xref="EnsemblGenomes-Gn:BSU32270" /db_xref="EnsemblGenomes-Tr:CAB15217" /db_xref="GOA:O32123" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014254" /db_xref="SubtiList:BG14044" /db_xref="UniProtKB/Swiss-Prot:O32123" /translation="MVKGTIKEKYGIHIRQLSMYQHTYQCFQTPNSYFLIVPVSQFSE TELAELYYMSQYLQEQSDPYVSVFIFTKEGELTFEHEGKTYALLKAAPPYSNRAFSIG AELAEFHRKGRGYPYEVKAAGRIGQWKDLWGKRIDQLEAFWQRKVQTPPHEPFDKKMI ESFPYYLGLSENAIQYLVDTELDDKPQAADSGTICHQRMERHTWSPESLIRIPADWVF DHASRDLAEYMRHTFLHHRQDFNQQGFLFLQEYEQVTPLSSFSKRLLYSRLLFPLHYF EIVESYYMSSESEKHYFEEQLDFILNDCGRYEQFLNTAQEFMNMRAQKLFVPRVSWLG KGSSR*" /label="cotNH CDS" gene complement(2749893..2750912) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /label="cotNH gene" promotor_-35 2750720..2750725 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2750741..2750759 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2750745 /Source="Nicolas_upshifts" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2750935..2750953) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2750942) /Source="Nicolas_upshifts" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2750951..2750956 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2750969..2750974) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2750972..2751036 /Source="Nicolas_S_feature" /locus_tag="new_3317409_3317473" /HighExp="S4, S5, S3, S6, S7, B36, S8, LoTm, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1247" promotor_-10 2750972..2750990 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2750972 /Source="Nicolas_upshifts" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2751009..2751018 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2751031..2751050 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2751038 /Source="Nicolas_upshifts" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="upshifts" CDS 2751065..2751565 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_391108.1" /db_xref="EnsemblGenomes-Gn:BSU32280" /db_xref="EnsemblGenomes-Tr:CAB15218" /db_xref="GOA:O32124" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="SubtiList:BG14043" /db_xref="UniProtKB/Swiss-Prot:O32124" /translation="MSENEQFSQMEAKARARMKERGVEVSDIAELVFFLQKKYHPDLT IDECTLNVNRVLAKREVQNAILTGIELDVLAEQKKLSEPLQTMLEIDESLYGVDEVLA FSIVNIYGSIGFTNYGYIDKEKPGILKRLNDKSTGECHTFLDDIVGAISAAASSRLAH RARHTE*" /label="yutG CDS" gene 2751065..2751565 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /label="yutG gene" CDS complement(2751592..2752362) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /EC_number="3.1.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15664928, 16766528, 27907199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15664928, 16766528, 27907199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5' nucleotidase, promiscuous" /protein_id="NP_391109.1" /db_xref="EnsemblGenomes-Gn:BSU32290" /db_xref="EnsemblGenomes-Tr:CAB15219" /db_xref="GOA:O32125" /db_xref="InterPro:IPR006354" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3PDW" /db_xref="SubtiList:BG14042" /db_xref="UniProtKB/Swiss-Prot:O32125" /translation="MKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTN NSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIE ENGLTFGGENADFVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPG NGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINA GMDTLLVHTGVTKREHMTDDMEKPTHAIDSLTEWIPYI*" /label="nucF CDS" gene complement(2751592..2752362) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /label="nucF gene" downshifts complement(2751620) /Source="Nicolas_upshifts" /id="D1676" /incds=0 /nref=137 /ntot=243 /MaxReadThrough="2.15034" /MaxDrop="4.82801" /score="8.09889752" /energy="-15.6" /TU="NA" /idTUdmin="U2535" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2752391..2752825) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391110.1" /db_xref="EnsemblGenomes-Gn:BSU32300" /db_xref="EnsemblGenomes-Tr:CAB15220" /db_xref="InterPro:IPR008201" /db_xref="PDB:1YLM" /db_xref="SubtiList:BG14041" /db_xref="UniProtKB/Swiss-Prot:O32126" /translation="MYFVDRSKIEKTLGFFEHQLALFDSQTDWQSEIGELALQRIGHL LIECILDTGNDMIDGFIMRDPGSYDDIMDILVDEKVVTEKEGDELKKLIAYRKTLVQQ YLLADSGELYRLIKAHQTALQDFPKRIRSYLETELGPVSAFK*" /label="yutE CDS" gene complement(2752391..2752825) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /label="yutE gene" CDS complement(2752849..2753124) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12770717, 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391111.2" /db_xref="EnsemblGenomes-Gn:BSU32310" /db_xref="EnsemblGenomes-Tr:CAB15221" /db_xref="InterPro:IPR009370" /db_xref="PDB:2KL5" /db_xref="SubtiList:BG14040" /db_xref="UniProtKB/Swiss-Prot:O32127" /translation="MILIQNAEFELVHNFKDGFNEEAFKARYSDILNKYDYIVGDWGY GQLRLKGFFDDQNQKATFETKISTLDEYIYEYCNFGCAYFVLKRIRK*" /label="yutD CDS" gene complement(2752849..2753124) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /label="yutD gene" promotor_-10 complement(2753144..2753163) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2753169) /Source="Nicolas_upshifts" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2753171..2753863) /Source="Nicolas_S_feature" /locus_tag="new_3319608_3320300_c" /HighExp="G135, G150, G180, H2O2, LBGtran, LBGexp, Paraq, dia15, C90, HiOs" /AntisenseName="yutC" /AntisenseCor="-0.57886192731570996" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1248" promotor_-35 complement(2753177..2753184) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2753187..2753193 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2753208..2753219 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2753216 /Source="Nicolas_upshifts" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="upshifts" CDS 2753239..2753871 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative sporulation-related lipoprotein" /protein_id="NP_391112.1" /db_xref="EnsemblGenomes-Gn:BSU32320" /db_xref="EnsemblGenomes-Tr:CAB15222" /db_xref="GOA:O32128" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG14039" /db_xref="UniProtKB/Swiss-Prot:O32128" /translation="MKRTAVSLCLLTGLLSGCGGAGLDNAQNVRNQTQNQTKPIHVSD RNEAFNRHNENEQFGYVRYQKEQFDGEQQKTPVMNREETAHMISSLTVQLPHIQDAAT LVTDREALVVYKTDSKNRELTADQVKKTAASVIPRYYHVYISDNPNHMQSVENYSNLG SGSRDIREIMSGTIQEMKTSPQGSPVSENENANGETRQDMKIDRNDKNAR*" /label="yutC CDS" gene 2753239..2753871 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /label="yutC gene" downshifts 2753832 /Source="Nicolas_upshifts" /id="D1677" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="1.84979" /MaxDrop="3.55825" /score="-2.38634221" /energy="-9.6" /TU="NA" /idTUdmin="U2536" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2753887..2754783) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /EC_number="2.8.1.8" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15362861, 16835858, 19028902, 19820084, 25341020; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoyl synthase (lipoic acid synthetase)" /protein_id="NP_391113.2" /db_xref="EnsemblGenomes-Gn:BSU32330" /db_xref="EnsemblGenomes-Tr:CAB15223" /db_xref="GOA:O32129" /db_xref="InterPro:IPR003698" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031691" /db_xref="SubtiList:BG14038" /db_xref="UniProtKB/Swiss-Prot:O32129" /translation="MAKKDEHLRKPEWLKIKLNTNENYTGLKKLMRENNLHTVCEEAK CPNIHECWAVRRTATFMILGSVCTRACRFCAVKTGLPTELDLQEPERVADSVALMNLK HAVITAVARDDQKDGGAGIFAETVRAIRRKSPFTTIEVLPSDMGGNYDNLKTLMDTRP DILNHNIETVRRLTPRVRARATYDRSLEFLRRAKEMQPDIPTKSSIMIGLGETKEEII EVMDDLLANNVDIMAIGQYLQPTKKHLKVQKYYHPDEFAELKEIAMQKGFSHCEAGPL VRSSYHADEQVNEASKKRQAQA*" /label="lipA CDS" gene complement(2753887..2754783) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /label="lipA gene" downshifts complement(2753908) /Source="Nicolas_upshifts" /id="D1678" /incds=0 /nref=186 /ntot=261 /MaxReadThrough="3.83236" /MaxDrop="5.33309" /score="14.803008" /energy="-9.6" /TU="U2537" /idTUdmin="U2537" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(2754784..2754918) /Source="Nicolas_S_feature" /locus_tag="new_3321221_3321355_c" /HighExp="HiOs, LBGtran, dia15, dia5, C90, Diami, dia0, LBGexp, Heat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1249" promotor_-10 complement(2754905..2754924) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-10" upshifts complement(2754918) /Source="Nicolas_upshifts" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="upshifts" promotor_-35 complement(2754940..2754944) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-35" promotor_-35 2754958..2754964 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2754978..2754989 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2754990 /Source="Nicolas_upshifts" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="upshifts" CDS 2755018..2755998 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /EC_number="3.4.-.-" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12813075; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific L-Ala-D-Glu endopeptidase" /protein_id="NP_391114.2" /db_xref="EnsemblGenomes-Gn:BSU32340" /db_xref="EnsemblGenomes-Tr:CAB15224" /db_xref="GOA:O32130" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG13975" /db_xref="UniProtKB/Swiss-Prot:O32130" /translation="MKVLLSALLLLLFAFEPSASGKKLSDPVLSKRMELYHKIEAVTQ IPWYALAAVDQYEENVRSNRKDLPEKAGIISIYIPDDIWSGPENPNPKDDAPLSIKVF DGIGMDGDGDGKAEVSNDEDILYTFSQYLLSYGTDEDNIRIGLWNYYRRDQTVGIISE FMKLFKAYGHIDLGEHAFPLPIRTDYSYRSTWGDARGFGGRRIHEGTDIFAHYGLPVK STCYGVVEMKGWNRFGGWRIGIRDINNTYHYFAHLNGFAKGIKTGQIVEPGQVIGSVG SSGYGPPGTAGKFPPHLHYGMYKDNGRTEWSFDPYPHLRAWERYEYQKKK*" /label="lytH CDS" gene 2755018..2755998 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /label="lytH gene" upshifts complement(2755096) /Source="Nicolas_upshifts" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2755110..2755129) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2755146..2755149) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2755990 /Source="Nicolas_upshifts" /id="D1679" /incds=0 /nref=35 /ntot=74 /MaxReadThrough="0.613989999999999" /MaxDrop="8.59238" /score="-3.31011906" /energy="-20" /TU="NA" /idTUdmin="U2538" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2756026..2756790) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12662922, 23388828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 23388828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein required for membrane fission during spore formation" /protein_id="NP_391115.1" /db_xref="EnsemblGenomes-Gn:BSU32350" /db_xref="EnsemblGenomes-Tr:CAB15225" /db_xref="GOA:O32131" /db_xref="InterPro:IPR014197" /db_xref="SubtiList:BG13976" /db_xref="UniProtKB/Swiss-Prot:O32131" /translation="MPRYRGPFRKRGPLPFRYVMLLSVVFFILSTTVSLWMINGSIKP VLMDIGEMETKRIATEVIQDSIEDYMSDSENMKDMFQMNSDENGNLTTIDFNTQVVNS VKTKVTKQLQAHLKEMETHTGHSGASENIMINIPLGQVTGNSLLGNLGPKIPVRFNLI GDAFTDVKTKIKPYGINNALIDISIFVEIKVKVIIPFASKTAVVTNNVPVSIKAVQGE VPQFYNGSGGSGVTPSVQLPSSKENGADSKKEKSSK*" /label="fisB CDS" gene complement(2756026..2756790) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /label="fisB gene" downshifts complement(2756042) /Source="Nicolas_upshifts" /id="D1680" /incds=0 /nref=74 /ntot=226 /MaxReadThrough="3.15258" /MaxDrop="6.53891" /score="23.5286262" /energy="-12.4" /TU="NA" /idTUdmin="U2540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2756804..2756822) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2756812) /Source="Nicolas_upshifts" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2756838..2756843) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2756863..2757168) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391116.1" /db_xref="EnsemblGenomes-Gn:BSU32360" /db_xref="EnsemblGenomes-Tr:CAB15226" /db_xref="InterPro:IPR014931" /db_xref="InterPro:IPR036493" /db_xref="SubtiList:BG13977" /db_xref="UniProtKB/Swiss-Prot:O32132" /translation="MVNLTPIMIEGQPFTAVTVKLPKTNFMAVANDHGYIMCGALDVA LLNEKLKERGIVAGRAVGVRTIDQLLDAPLESVTYAAEDLGIKVGMSGREALLKMMK* " /label="yunC CDS" gene complement(2756863..2757168) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /label="yunC gene" downshifts complement(2756871) /Source="Nicolas_upshifts" /id="D1681" /incds=0 /nref=3 /ntot=128 /MaxReadThrough="5.18714" /MaxDrop="3.9347" /score="-2.65376612" /energy="-18.9" /TU="U2541,U2543,U2544" /idTUdmin="U2540" /TUdmin="-829" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2757182..2757201) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2757205) /Source="Nicolas_upshifts" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2757215..2757223) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2757233..2758621) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nuclease/nucleotidase/phosphoesterase" /protein_id="NP_391117.1" /db_xref="EnsemblGenomes-Gn:BSU32370" /db_xref="EnsemblGenomes-Tr:CAB15227" /db_xref="GOA:O32133" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR011240" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG13978" /db_xref="UniProtKB/Swiss-Prot:O32133" /translation="MKEKLRLYHTNDLHSHFENWPKIVDYIEQKRKEHQSDGEETLVF DIGDHLDRFQFVTEATFGKANVDLLNRLHIDGAAIGNNEGITLPHEELAALYDHAEFP VIVSNLFDKNGNRPSWAVPYHIKSLKNGMSIAFLGVTVPYYPVYDKLGWTVTDALESI KETILEVKGQADIIVLLSHLGILDDQAVAEAVPEIDVILESHTHHLLEDGQVVNGVLL ASAEKYGHYVGCVEITVDSVQRSINSKTASVQNMAEWTGESAETKAFLNEKEREAEEK LSDAVAELAQDAEVKWFEESELPLLLAYALKEWCETDISMVNSGVILGPLKAGPVTKL DLHRICPHPINPVAVRLTGEELKETIVHAASEQMEQLRIKGLGFRGEVMGKMVYAGVE VETKRLDDGITHVTRITLNGEDIEKHKQYSVAVLDMFTLGKLFPLIRDAAEKEYFMPE FLRDLLAWKLAQ*" /label="yunD CDS" gene complement(2757233..2758621) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /label="yunD gene" CDS complement(2758641..2759462) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391118.1" /db_xref="EnsemblGenomes-Gn:BSU32380" /db_xref="EnsemblGenomes-Tr:CAB15228" /db_xref="GOA:O32134" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13979" /db_xref="UniProtKB/Swiss-Prot:O32134" /translation="MSFVILVVLGLIAGTVGSLIGLGGGIVIVPSLMFLSTVTQLFQD VTPQVAIGTSLLVIIFTGLSSTLAYIKYKTVDYKSGLIFFIGSGPGSMIGAYVSKLFN SNSFSVWFGIFMILISLSLMLKAKARPINKAHKGIIRTFQDDAGEPYTYSYQASVGIA IAFVVGFLGGLFGIGGGSLMVPAMMLLFLFPPKVAVATSMFIIFLSSMTGSVSHMISG HVNWLYALALVPGAWFGGKLGAAINRKMQTKTIVMIMRIVLILIGCQLIYEGIFS*" /label="yunE CDS" gene complement(2758641..2759462) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /label="yunE gene" CDS complement(2759480..2760328) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391119.2" /db_xref="EnsemblGenomes-Gn:BSU32390" /db_xref="EnsemblGenomes-Tr:CAB15229" /db_xref="InterPro:IPR002763" /db_xref="InterPro:IPR036520" /db_xref="SubtiList:BG13980" /db_xref="UniProtKB/Swiss-Prot:O32135" /translation="MIYIGLTGWGDHDSIYPPKTASQKKLQAYSSHFPIVELDASFYA IQPARNNEKWVKETPETFQFIVKAYQGMTGHQRGEIPFDSKEEMFDAFKVSLTPYLHS NKLAMVLFQFPPWFDCKKENVAYLRWCKHQMGDIPCALEFRNRSWFSPPFYEQTLSFM KAEGWIHSVCDEPQIGEGSVPTVLRATDENKTLVRFHGRNKQGWMKPDGGKNWREVRY LYRYNQQELEDWKKHLNELQQQCKDVFVLFNNNSGGDAADNGKQMLELLDIEYSGLAP RQLDLF*" /label="yunF CDS" gene complement(2759480..2760328) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /label="yunF gene" promotor_-35 2759847..2759852 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2759868..2759886 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2759882 /Source="Nicolas_upshifts" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2760339..2760358) /Source="Nicolas_upshift_promotors" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2760354) /Source="Nicolas_upshifts" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2760366..2760713) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391120.1" /db_xref="EnsemblGenomes-Gn:BSU32400" /db_xref="EnsemblGenomes-Tr:CAB15230" /db_xref="SubtiList:BG13981" /db_xref="UniProtKB/Swiss-Prot:O32136" /translation="MEHVKYILKQSWSRHSSSKWTEECPSCGQCGVTALVIQDHFGGT IFKTRVDESWHFYNSINGVVYDFTSEQFQAPIEYQHIPSSREEAFLDTNEEQYQHLRE AFSRHMNSISEET*" /label="yunG CDS" gene complement(2760366..2760713) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /label="yunG gene" promotor_-10 complement(2760726..2760745) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2760745) /Source="Nicolas_upshifts" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2760759..2760765) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2760810..2762150) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /EC_number="3.5.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoinase" /protein_id="NP_391121.1" /db_xref="EnsemblGenomes-Gn:BSU32410" /db_xref="EnsemblGenomes-Tr:CAB15231" /db_xref="GOA:O32137" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR017593" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13982" /db_xref="UniProtKB/Swiss-Prot:O32137" /translation="MAYDMVIKGAKAVTPDGVIEADIVVQNGVIAEIGSDIEASGTEI IQADGKYVFPGVIDCHVHFNEPGREDWEGFETGSQMMAAGGCTTYFDMPLNCIPSTVT AEHLLAKAELGRQKSAVDFALWGGLVPGHIEDIRPMAEAGAIGFKAFLSKSGTDEFRS VDERTLLKGMAEIAAAGKILALHAESDAITSYLQMVLANKGKVDADAYAASRPEEAEV EAVYRTIQYAKVTGCPVHFVHISTAKAVRLIREAKQEGLDVSVETCPHYVLFSHDDLR QRGSVAKCAPPLRSRQSKETLIETLIAGDIDMVSSDHSPCRPSLKREDNMFLSWGGIS GGQFTLLGMLELALEHQIPFETIAEWTAAAPAKRFGLQKKGRLEAGCDADFVLVSMEP YTVTRESMFAKHKKSIYEGHTFPCSISATYSKGRCVYNDGEKVTEIDGALVVPS*" /label="pucH CDS" gene complement(2760810..2762150) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /label="pucH gene" downshifts complement(2760838) /Source="Nicolas_upshifts" /id="D1682" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.88847" /MaxDrop="3.89144" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-4796" /isTUend="FALSE" /label="downshifts" downshifts complement(2761894) /Source="Nicolas_upshifts" /id="D1683" /incds=1 /nref=1 /ntot=7 /MaxReadThrough="3.38784" /MaxDrop="3.36547" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-5852" /isTUend="FALSE" /label="downshifts" promotor_-35 2762207..2762213 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2762227..2762246 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2762229..2762247) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2762235 /Source="Nicolas_upshifts" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2762236..2762324 /Source="Nicolas_S_feature" /locus_tag="new_3328673_3328761" /HighExp="BT, Cold, S0, LBGexp, S1, Lbtran, G150, T-1.40H, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S1250" upshifts complement(2762246) /Source="Nicolas_upshifts" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2762263..2762268) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2762325..2763920 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 12374841" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 12374841; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine degradation operon" /protein_id="NP_391122.1" /db_xref="EnsemblGenomes-Gn:BSU32420" /db_xref="EnsemblGenomes-Tr:CAB15232" /db_xref="GOA:O32138" /db_xref="InterPro:IPR012914" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG13983" /db_xref="UniProtKB/Swiss-Prot:O32138" /translation="MNILDVMKIPAFENANLIAGKAGGEREVQHVNMMDAPDIVDFLH KNELLVTTAYHLKDHPHQLSELIRQMAKRGCAGLGIKTKRYLEDIPKEIIELADSYAF PIIELPEHIRLGDIVNATLSHILDMRSNELQQAIYAHKKFTNHIMSGKGLQSLLKKVS DILQLPVLLLDQHAKMLSASHQISVETEKLKGTLNTVSGPFFTCFSTISDQKTYSVLP IYNHEKNCGYLLIPDMVQAGDKGLILTIEQAANVISFELLKENALKQFSRRARNEFFN NFIERTFSSDDEIKNRAKEFKLRWDQKYMCIAGKLDRNDESISFTENQLASDSVFEFL EGELSAFPFPPHFFMKGNVGIILIEATDSWSEMHASVISFLEQFQTQVSAQFKRTVSF GISNICQKLIDVPDAFTEASDALQSGHLSRSTAFIQVYHAKDVPELLRLLPVEDLKKF YNSTLQSLAEKQQEDQSLLHTLSVYLETHCQISETAKRLYVHRNTVIYRLEKCEELLG KSLKDPETTMRLRLALRMQRLIS*" /label="pucR CDS" gene 2762325..2763920 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /label="pucR gene" CDS 2764065..2765414 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease" /protein_id="NP_391123.1" /db_xref="EnsemblGenomes-Gn:BSU32430" /db_xref="EnsemblGenomes-Tr:CAB15233" /db_xref="GOA:O32139" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13984" /db_xref="UniProtKB/Swiss-Prot:O32139" /translation="MKKRSFKVFTLSLQHVLAMYAGAILVPLLVGRALNVTTEQLSYL LAIDLLTCGVATLLQTLRGTYIGIGLPVMLGSSFVAVTPMIAIGSNYGIHAIYGSIIA AGVFIFLFARFFGKLTVLFPPVVTGTVVTLIGLSLVPTGVKNMAGGEKINGSANPEYG SLENLLLSVGVLVLILVLNRFLKGFARTLSVLIGIAAGTAAAAIMGKVSFSSVTEAPF FQIPKPFYFGAPAFEIGPILTMLIVGIVIIVESTGVFYAIGKICGRPLTDKDLVKGYR AEGIAILIGGLFNAFPYNTFAQNAGLLQLTKVKTRNIVVTAGCILVCLGLIPKIAALA SAVPAAVLGGATVVMFGMVIASGVKMLSTADLKNQYHLLTIACSIALGIGASTAPGIF AEFPAPIRILVSDGTITGSLTAIFLNLFFSLRDKKELTAQQTELPVLEHTLALEKEV* " /label="pucJ CDS" gene 2764065..2765414 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /label="pucJ gene" CDS 2765420..2766712 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease subunit" /protein_id="NP_391124.1" /db_xref="EnsemblGenomes-Gn:BSU32440" /db_xref="EnsemblGenomes-Tr:CAB15234" /db_xref="GOA:O32140" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13985" /db_xref="UniProtKB/Swiss-Prot:O32140" /translation="MKEQHNALQLMMLGLQHMLAMYAGAILVPLIVGAAIGLNAGQLT YLIAIDLFMCGAATLLQLWRNRYFGIGLPVVLGCTFTAVGPMISIGSTYGVPAIYGAI IAAGLIVVLAAGFFGKLVRFFPPVVTGSVVMIIGISLIPTAMNNLAGGEGSKEFGSLD NVLLGFGVTAFILLLFYFFKGFIRSIAILLGLIAGTAAAYFMGKVDFSEVLEASWLHV PSLFYFGPPTFELPAVVTMLLVAIVSLVESTGVYFALADITNRRLSEKDLEKGYRAEG LAILLGGLFNAFPYTAFSQNVGIVQLSKMKSVNVIAITGIILVAIGLVPKAAALTTVI PTPVLGGAMIVMFGMVISYGIKMLSSVDLDSQGNLLIIASSVSLGLGATTVPALFSSL SGAASVLAGSGIVIGSLTAIALHAFFQTKQPNSADIKT*" /label="pucK CDS" gene 2765420..2766712 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /label="pucK gene" CDS 2766725..2768209 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /EC_number="1.7.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12823818, 17567580, 20168977, 23760935, 28531234" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12823818, 17567580, 20168977, 23760935, 28531234; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="urate oxidase with peroxide reductase N-terminaldomain" /protein_id="NP_391125.1" /db_xref="EnsemblGenomes-Gn:BSU32450" /db_xref="EnsemblGenomes-Tr:CAB15235" /db_xref="GOA:O32141" /db_xref="InterPro:IPR002042" /db_xref="InterPro:IPR017580" /db_xref="InterPro:IPR018020" /db_xref="InterPro:IPR019842" /db_xref="InterPro:IPR036778" /db_xref="SubtiList:BG13986" /db_xref="UniProtKB/Swiss-Prot:O32141" /translation="MFTMDDLNQMDTQTLTDTLGSIFEHSSWIAERSAALRPFSSLSD LHRKMTGIVKAADRETQLDLIKKHPRLGTKKTMSDDSVREQQNAGLGKLEQQEYEEFL MLNEHYYDRFGFPFILAVKGKTKQDIHQALLARLESERETEFQQALIEIYRIARFRLA DIITEKGETQMKRTMSYGKGNVFAYRTYLKPLTGVKQIPESSFAGRDNTVVGVDVTCE IGGEAFLPSFTDGDNTLVVATDSMKNFIQRHLASYEGTTTEGFLHYVAHRFLDTYSHM DTITLTGEDIPFEAMPAYEEKELSTSRLVFRRSRNERSRSVLKAERSGNTITITEQYS EIMDLQLVKVSGNSFVGFIRDEYTTLPEDGNRPLFVYLNISWQYENTNDSYASDPARY VAAEQVRDLASTVFHELETPSIQNLIYHIGCRILARFPQLTDVSFQSQNHTWDTVVEE IPGSKGKVYTEPRPPYGFQHFTVTREDAEKEKQKAAEKCRSLKA*" /label="pucL CDS" gene 2766725..2768209 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /label="pucL gene" CDS 2768209..2768553 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /EC_number="3.5.2.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 16098976, 16782815, 21795808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 16098976, 16782815, 21795808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-hydroxyisourate hydrolase; also uricase subunit" /protein_id="NP_391126.2" /db_xref="EnsemblGenomes-Gn:BSU32460" /db_xref="EnsemblGenomes-Tr:CAB15236" /db_xref="GOA:O32142" /db_xref="InterPro:IPR000895" /db_xref="InterPro:IPR014306" /db_xref="InterPro:IPR023416" /db_xref="InterPro:IPR023418" /db_xref="InterPro:IPR023419" /db_xref="InterPro:IPR036817" /db_xref="PDB:2H0E" /db_xref="PDB:2H0F" /db_xref="PDB:2H0J" /db_xref="SubtiList:BG13987" /db_xref="UniProtKB/Swiss-Prot:O32142" /translation="MGKLTTHILDLTCGKPAANVKIGLKRLGESIMKEVYTNNDGRVD VPLLAGEELMSGEYVMEFHAGDYFASKNMNAADQPFLTIVTVRFQLADPDAHYHIPLL LSPFGYQVYRGS*" /label="pucM CDS" gene 2768209..2768553 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /label="pucM gene" promotor_-35 2768275..2768278 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2768296..2768315 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2768308 /Source="Nicolas_upshifts" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2768528 /Source="Nicolas_upshifts" /id="D1684" /incds=0 /nref=3 /ntot=90 /MaxReadThrough="1.80149" /MaxDrop="3.57243" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2547" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2768569..2768956) /Source="Nicolas_S_feature" /locus_tag="new_3335006_3335393_c" /HighExp="BT, S8, T2.0H, LBGstat, Cold, Etha, Sw, T1.0H, T1.30H, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1251" promotor_-35 2768916..2768925 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2768938..2768957 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2768941 /Source="Nicolas_upshifts" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="upshifts" ncRNA complement(2768977..2769108) /ncRNA_class="antisense_RNA" /gene="auzJ" /locus_tag="BSU_ncRNA_2" /product="putative antisense RNA for type I YuzJ toxin" /note="Evidence 3: Putative function from multiple computational evidences" /label="auzJ ncRNA" CDS 2768977..2769108 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 20525796, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097780.1" /db_xref="EnsemblGenomes-Gn:BSU32469" /db_xref="EnsemblGenomes-Tr:CAX52686" /db_xref="GOA:C0H3Q7" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Q7" /translation="MGFYNSGGYSGNSGYSNGFGSSFALIVVLFILLIIVGAAIFNY* " /label="yuzJ CDS" gene 2768977..2769108 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /label="yuzJ gene" gene complement(2768977..2769108) /gene="auzJ" /locus_tag="BSU_ncRNA_2" /label="auzJ gene" S_feature 2769109..2769177 /Source="Nicolas_S_feature" /locus_tag="new_3335546_3335614" /HighExp="BT, B36, S8, G/S, B60, Pyr, Glucon, C30, S7, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1252" downshifts 2769144 /Source="Nicolas_upshifts" /id="D1685" /incds=0 /nref=10 /ntot=25 /MaxReadThrough="0.61379" /MaxDrop="6.43101" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2548" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2769314..2769835) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, iron-sulfur subunit" /protein_id="NP_391127.1" /db_xref="EnsemblGenomes-Gn:BSU32470" /db_xref="EnsemblGenomes-Tr:CAB15237" /db_xref="GOA:O32143" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR002888" /db_xref="InterPro:IPR006058" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017611" /db_xref="InterPro:IPR036010" /db_xref="InterPro:IPR036884" /db_xref="SubtiList:BG13988" /db_xref="UniProtKB/Swiss-Prot:O32143" /translation="MDIKEAGPFPVKKEQFRMTVNGQAWEVAAVPTTHLSDLLRKEFQ LTGTKVSCGIGRCGACSILIDGKLANACMTMAYQADGHSITTIEGLQKEELDMCQTAF LEEGGFQCGYCTPGMIIALKALFRETPQPSDKDIEEGLAGNLCRCTGYGGIMRSACRI RRELNGGRRESGF*" /label="pucE CDS" gene complement(2769314..2769835) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /label="pucE gene" CDS complement(2769826..2772063) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, substrate and molybdenumcofactor subunit" /protein_id="NP_391128.1" /db_xref="EnsemblGenomes-Gn:BSU32480" /db_xref="EnsemblGenomes-Tr:CAB15238" /db_xref="GOA:O32144" /db_xref="InterPro:IPR000674" /db_xref="InterPro:IPR008274" /db_xref="InterPro:IPR017609" /db_xref="InterPro:IPR036856" /db_xref="InterPro:IPR037165" /db_xref="SubtiList:BG13989" /db_xref="UniProtKB/Swiss-Prot:O32144" /translation="MIINKPSRVRPDGRGKVTGELKYMTDLSFPGMLYGKVLRSAYPH AEIVSVCTIKAEKMEGVQAVVTHKDVPGLNRFGIVIPDQPVLCEDRVRYVGDAIAAVA AETEEIAEAALELIQVEYKELEVMDSPEKALRPNAQRLHEDGNILHRAFFSNGDVEEG FQASDTVFEETYELPRQMHTYMETEGGVAVPEDDGGFTMYAGTQHGYKDRFQLARIFD IPEEKIRIVSSPMGGSFGGKDELNIQPYAALLALKSGRPVKIHQTRKESVRSGIKRHP MKITIKTGADHSGNLLAHDVKIVADTGAYATLGPAVLDFSVEHAAGPYRIPNIRTEGI SVFTNNGVAGEFRGFGGNQITFALETHLDRLSGMLGIDPLELRRKNIRKPHDLGPLEH RIAPTDGAAQVLNAISKSPILKKTSRNCGYLQRGTGAAITMHGGGLGFGRMDAAGGRL SLSSEGKITASFGFEECGQGILAAIEQIVMEELGCAAEDISIVIGDTAKVPKSGSSTA SRGTSMVWHAIQRLKKPFLAQLKKRAAEWSGCSAENLIPGAAGLRDKNTKALVVTYKE LAEKGPLAEETAFDFPTTPDPVVGGHFLYSFGAAAVEVEVDLLTGDVKLIDCEHAIAA GPVVSPQGYRGQIEGGAAMALGYTLMEEAKMTDGRYAAENLDHYLIPGIKDVPDMKLI AIEDLMKGDVYGPRGVGEIGTIAITPAIVKAVHDAVGCWINKLPISREELLEAIDRKG LKQWT*" /label="pucD CDS" gene complement(2769826..2772063) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /label="pucD gene" CDS complement(2772064..2772897) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, FAD-binding subunit" /protein_id="NP_391129.1" /db_xref="EnsemblGenomes-Gn:BSU32490" /db_xref="EnsemblGenomes-Tr:CAB15239" /db_xref="GOA:O32145" /db_xref="InterPro:IPR002346" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR017612" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036683" /db_xref="SubtiList:BG13990" /db_xref="UniProtKB/Swiss-Prot:O32145" /translation="MNGQVTKARMNIQLWRPAALDEAYSLLEKLAPDVCAASGSTLLQ LQWDKGTLPKQHLVSLEGIDEMRGISTSDTHVSIGGLTSLNECRKNPLIKRALSCFSD AASAVAAPGIRSRATIGGNIASKIGDFIPLLLVLGAELIVYQKELIRLPLGAWLSEED FRTAIVTRVIIPRAEGERVFYHKLGRRQAFTGAAAVAAGRFLKDGSIRLAAGHADITP RRLLDSEAKWMAPGWDPHELYKTLIHELPFSSDVFMSAAYRKKAAANVIMAELMAEGG E*" /label="pucC CDS" gene complement(2772064..2772897) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /label="pucC gene" CDS complement(2772894..2773511) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /EC_number="2.7.7.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11344136, 21528011; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin cofactor synthesis cytidylyl transferase" /protein_id="NP_391130.2" /db_xref="EnsemblGenomes-Gn:BSU32500" /db_xref="EnsemblGenomes-Tr:CAB15240" /db_xref="GOA:O32146" /db_xref="InterPro:IPR017615" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13991" /db_xref="UniProtKB/Swiss-Prot:O32146" /translation="MRSPYLIGVFLAAGKSRRMGQNKLALPLKGENIGSLSLKTALSS RLDHVLVVERTEHASLEWIGAPYHAPPFQKRWSLHVCQDAEKGQGHSVSSGVRKAESM GADGIVILLADQPQLSVDHLNALVALAPESFAVSSFLGAFTPPIYFSSTCFPYVKGLK GDEGARRLLKSGQLGAGAVLEAKDSGELDDIDTPEEYDMVRRAMS*" /label="pucB CDS" gene complement(2772894..2773511) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /label="pucB gene" downshifts complement(2773003) /Source="Nicolas_upshifts" /id="D1686" /incds=1 /nref=3 /ntot=13 /MaxReadThrough="5.34639" /MaxDrop="3.22355" /score="-4.87239629" /energy="-9.9" /TU="U2549" /idTUdmin="U2549" /TUdmin="-3827" /isTUend="FALSE" /label="downshifts" CDS complement(2773508..2774500) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10217763, 11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217763, 11344136, 12029039; Product type f: factor" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase molybdopterin recruitmentfactor" /protein_id="NP_391131.1" /db_xref="EnsemblGenomes-Gn:BSU32510" /db_xref="EnsemblGenomes-Tr:CAB15241" /db_xref="GOA:O32147" /db_xref="InterPro:IPR003777" /db_xref="InterPro:IPR027051" /db_xref="SubtiList:BG13992" /db_xref="UniProtKB/Swiss-Prot:O32147" /translation="MGNFHTMLDALLEDQEEAVLATIVQVEGSAYRKAGASMLFKKKG RRIGLLSGGCVEEDVFQRISALGDQLTSTLIPYDMRSEDDLSWGMGAGCNGIIHVHAE RITQEKRRHYEKVRDCLHSGKAVTSVIKIESSHYLFLTENGHFGNWPDAPLQDIQRTV STLHLPHFDQTTNMFIQRIEPKPRLILFGAGPDNVPLANLAADTGFSVIVTDWRPAYC TSSLFPKADQLITAFPEQMLSEFQFFPHDAAVVATHHYQHDQTIINFLFSQNLHYIGL LGSANRTKRLLSGKHPPSHFYSPVGLKIGAEGPEEIAVSVVAEIIQTRKRVAVV*" /label="pucA CDS" gene complement(2773508..2774500) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /label="pucA gene" S_feature complement(2774501..2774587) /Source="Nicolas_S_feature" /locus_tag="new_3340938_3341024_c" /HighExp="BT, Cold, Sw, T-1.10H, S1, C30, S0, T-0.40H, T-3.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.607" /TUlongSig="NA" /TUlongPSig="NA" /label="S1253" promotor_-10 complement(2774565..2774584) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2774587) /Source="Nicolas_upshifts" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2774598..2774603) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2774729..2775979) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 20852637, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 20852637, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(S)-ureidoglycine-glyoxylate aminotransferase (PLP-dependent)" /protein_id="NP_391132.1" /db_xref="EnsemblGenomes-Gn:BSU32520" /db_xref="EnsemblGenomes-Tr:CAB15242" /db_xref="GOA:O32148" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR024169" /db_xref="PDB:3ISL" /db_xref="SubtiList:BG13993" /db_xref="UniProtKB/Swiss-Prot:O32148" /translation="MSGRRELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTG IMNETMEMLRELFQTKNRWAYPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLT EIAERYGANVHMLECEWGTVFDPEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGE ACRTEDALFIVDAVATIGGCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITYNERVADV IAARKKVERGIATQADRAALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATTMLYAL REGVRLVLEEGLETRFERHRHHEAALAAGIKAMGLRLFGDDSCKMPVVTCVEIPGGID GESVRDMLLAQFGIEIASSFGPLAGKIWRIGTMGYSCRKENVLFVLAGLEAVLLRHNA GIEAGKALQAALDVYENAGRQAAV*" /label="pucG CDS" gene complement(2774729..2775979) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /label="pucG gene" CDS complement(2775996..2777234) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /EC_number="3.5.3.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11344136, 17362992, 25020232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoate amidohydrolase" /protein_id="NP_391133.1" /db_xref="EnsemblGenomes-Gn:BSU32530" /db_xref="EnsemblGenomes-Tr:CAB15243" /db_xref="GOA:O32149" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010158" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13994" /db_xref="UniProtKB/Swiss-Prot:O32149" /translation="MEKQKLSVKNSITDYIEWLAQYGASADGGVTRLLYTKEWMDAQL AVKTEMSSFGLETRFDDVGNVFGRLSGTQSPDEVIVTGSHIDTVINGGKYDGAYGVLA AMLALKQLKETYGAPKKTLEAVSLCEEEGSRFPMTYWGSGNMTGVFSEQDAKEPRDES GVSLQTAMHESGFGKGVFQSAYRTDISAFVELHIEQGKTLEMSGRDLGIVTSIAGQRR YLVTLEGECNHAGTTSMKWRKDPLAASSRIIHELLLRSDELPDELRLTCGKITAEPNV ANVIPGRVQFSIDIRHQHQHVLEQFHQDMVALINGICLQKGIRAVIDEYMRIEPVPMD ERLKAAAFETALENGFSCEEMVSGAGHDAQMIGRRYPACMLFVPSRGGVSHSPKEYTS ARQLEIGVRALTDLLYKLAY*" /label="pucF CDS" gene complement(2775996..2777234) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /label="pucF gene" CDS 2777457..2777594 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514002.1" /translation="MNKLSWRGDVRGTDENRNAGSPQKQDLKIWKQEISASSKGTNLQ F*" /label="hypothetical protein CDS" gene 2777457..2777594 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /label="gene" promotor_-35 2777616..2777619 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2777634..2777653 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2777635 /Source="Nicolas_upshifts" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="upshifts" CDS 2777676..2778542 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1396690, 12490701, 12883447, 16291680, 25844442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1396690, 12490701, 12883447, 16291680, 25844442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular ribonuclease" /protein_id="NP_391134.1" /db_xref="EnsemblGenomes-Gn:BSU32540" /db_xref="EnsemblGenomes-Tr:CAB15244" /db_xref="GOA:O32150" /db_xref="InterPro:IPR007346" /db_xref="SubtiList:BG13995" /db_xref="UniProtKB/Swiss-Prot:O32150" /translation="MTKKAWFLPLVCVLLISGWLAPAASASAQTTLSLNDRLASSPSG TGSLLSLAAPAAPYADTDTYYEGAEGKTGDSLKSTLHRIISGHTMLSYSEVWNALKET DEDPRNPNNVILLYTNESRSKNLNGGNVGDWNREHVWAKSHGDFGTSKGPGTDIHHLR PADVQVNSARGNMDFDNGGTEYAKAPGNYYDGDSWEPRDDVKGDVARMLFYMAVRYEG DDGYPDLELNDKTGNGSAPYHGKQSVLLEWNKQDPVDDRERKRNEIIYEKYQHNRNPF IDHPEWADEIWP*" /label="bsnA CDS" gene 2777676..2778542 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /label="bsnA gene" downshifts 2778545 /Source="Nicolas_upshifts" /id="D1687" /incds=0 /nref=48 /ntot=190 /MaxReadThrough="0.45317" /MaxDrop="6.90997" /score="25.7790712" /energy="-15.5" /TU="NA" /idTUdmin="U2550" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(2778576..2779679) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23175651, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23175651, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid ABC transporter (ATP-bindingsubunit)" /protein_id="NP_391135.1" /db_xref="EnsemblGenomes-Gn:BSU32550" /db_xref="EnsemblGenomes-Tr:CAB15245" /db_xref="GOA:O32151" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR013611" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13996" /db_xref="UniProtKB/Swiss-Prot:O32151" /translation="MASLTFEHVKKSYHSQLTVKDFDLDVKDKELLVLVGPSGCGKST TLRMVAGLESISEGNLLIDGERVNDLPPKERDIAMVFQNYALYPHMTVFDNMAFGLKL RKMAKQEIAERVHAAARILEIEHLLKRKPKALSGGQRQRVALGRSIVREPKVFLMDEP LSNLDAKLRVTMRTEISKLHQRLEATIIYVTHDQTEAMTMGDRIVVMNEGEIQQVAKP HDIYHYPANLFVAGFIGSPGMNFLKGIIEQQHGELFFTNSSIRLHIPEEKAKRLKEKG YAGEQMIAGVRPEHITQMTGNDQLFDSVFQANVEVNENLGSELIVHVMAGDERLKVRL DGNTRIDAGDSIQLSVKMDHVVFFDAETEEAVY*" /label="frlP CDS" gene complement(2778576..2779679) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /label="frlP gene" downshifts complement(2778591) /Source="Nicolas_upshifts" /id="D1688" /incds=0 /nref=57 /ntot=215 /MaxReadThrough="3.04361" /MaxDrop="6.06171" /score="29.1144499" /energy="-15.5" /TU="NA" /idTUdmin="U2553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2779680..2780613) /Source="Nicolas_S_feature" /locus_tag="new_3346117_3347050_c" /HighExp="HiOs, T-5.40H, T5.0H, GM-0.1, S2, GM-0.2, GM 5, T-4.40H, T4.0H, SMM" /AntisenseName="frlR" /AntisenseCor="0.22682293682100099" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.971, 0.456, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1254" promotor_-35 2779717..2779724 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2779738..2779757 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2779748 /Source="Nicolas_upshifts" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2779799..2779805 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2779816 /Source="Nicolas_upshifts" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2779820..2779839 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2779861..2780589 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /experiment="publication(s) with functional evidences, PMID:21347729, 21398478, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21347729, 21398478, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FrlR transcriptional regulator (GntR family)" /protein_id="NP_391136.3" /db_xref="EnsemblGenomes-Gn:BSU32560" /db_xref="EnsemblGenomes-Tr:CAB15246" /db_xref="GOA:O32152" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2IKK" /db_xref="SubtiList:BG13997" /db_xref="UniProtKB/Swiss-Prot:O32152" /translation="MLNNGSSTPLYIQLKQIITDDIKKGVYSPTAKLPTENELCTKYN VSRITVRKAILDLVEEGYLIRQQGKGTFVKSPKLKRELIAVNGYSEFMESTGKKPKHH VLSHDIIPASKPIAEKLQIQPESPVVELKRILYNDDQPLTFEVTHYPLDLFPGIDTFI ADGVSMHDILKQQYKVVPTHNTKLLNVVYAQQEESKYLDCDIGDALFEIDKTAFTSND QPIYCSLFLMHTNRVTFTINSPYT*" /label="frlR CDS" gene 2779861..2780589 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /label="frlR gene" CDS complement(2780614..2781468) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 14641112, 15556630, 16153181, 21347729, 21398478, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fructoselysine kinase" /protein_id="NP_391137.1" /db_xref="EnsemblGenomes-Gn:BSU32570" /db_xref="EnsemblGenomes-Tr:CAB15247" /db_xref="GOA:O32153" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13998" /db_xref="UniProtKB/Swiss-Prot:O32153" /translation="MKLIAVGDNVVDYYQDQETFYPGGNALNVAVLAKRLGHESSYIG IVGNDEAAAHLLNVLKLEQVNADYIRQAHGENGMAIVTLDEQGDRIFVRSNKGGIQSR LRLAFQEKDVSFISGHDLLHTSVYSRLENDLPQLCGLVPVSFDFSTNREDDYLRRVCP YVTYAFFSGSDLSESECGELAKTAHGYGAKMVCMTRGGQGAILSAGDRVYHQPIVEAD IIDTLGAGDSFIAGFLTAFCVKQDITYALRQAAETAAKTCGVYGAFGYGYPYRLEDGG SSEKTRIL*" /label="frlD CDS" gene complement(2780614..2781468) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /label="frlD gene" misc_feature complement(2780801..2780820) /Source="Nicolas_upshift_promotors" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2780813) /Source="Nicolas_upshifts" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2780971..2781071) /Source="Nicolas_upshift_promotors" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2781011) /Source="Nicolas_upshifts" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2781482..2782384) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391138.1" /db_xref="EnsemblGenomes-Gn:BSU32580" /db_xref="EnsemblGenomes-Tr:CAB15248" /db_xref="GOA:O32154" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13999" /db_xref="UniProtKB/Swiss-Prot:O32154" /translation="MLPQKKTDSFRLEPVPDQHIEVKDKPRRKWYIGETSVWVFLFLY LIAIAYPLLWMVMSAFKNSDDIFEHSWSLPSSWHPENFVSAWNQGISSYFMNSVIVTA LTCVITVFISAWAAYGLSRFEFKGKGFFLVLCLGGLMLTPQVSLVPLYSIIQSLGLYN TYWALILPYAAYRIPFTIILIRSYFLSISKELEEAAYLDGCTSFGVFFRIFLPMSVPI LVTSGILTAYHTWNEFMFAIIFIDDENLRTIPAGLMQFRDALQTDWGVLLAGLTISAA PIIILFLLMQKYFVRGIASGSVKG*" /label="frlM CDS" gene complement(2781482..2782384) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /label="frlM gene" CDS complement(2782388..2783266) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391139.1" /db_xref="EnsemblGenomes-Gn:BSU32590" /db_xref="EnsemblGenomes-Tr:CAB15249" /db_xref="GOA:O32155" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14000" /db_xref="UniProtKB/Swiss-Prot:O32155" /translation="MVNQNKIIPYLFLVPALVFLLFVYIPIFENVFLSLFQWSSFSPE KTFIGLKNYVELFHDPVFYQALTNNVLYAVISIVCQVFGGLILAAVLEDKLVRKWSPF FRTVFFLPVVISMTVIALLFDFIYNPETGLLNQLLQAIGLDQLTRAWLGDDSTAMLSV IFVSQWQSVGYIAMLYIVSIQKIPDELYEAARLDGAGKIQQFFHITVPQTKEMSFVAV VMTLTGAFTVFNEPYILTGGGPGKASEVLSTFLYKSAFTKDMMGYASAIATVVLIITL ALSLMQMKFFKTGKEE*" /label="frlN CDS" gene complement(2782388..2783266) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /label="frlN gene" CDS complement(2783324..2784592) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 21347729; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose amino acid-binding lipoprotein" /protein_id="NP_391140.1" /db_xref="EnsemblGenomes-Gn:BSU32600" /db_xref="EnsemblGenomes-Tr:CAB15250" /db_xref="GOA:O32156" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG14001" /db_xref="UniProtKB/Swiss-Prot:O32156" /translation="MKKMLLFLIIAAVSMLTIAGCSSQSSSADGKVTLKFFHRWPKEP EKSYFEEVVKEFEKDHPDIDIQIEAVLNDSYKDKIKVMLGTTSPPDIYFSWSDEFAFK FIRGNKALDLSSYYKNDTDWSSQLVQSQITPFTYENKQYGVPWQMDAKSFFYNKDIFQ KLNLDPPKTWDELIDVSKKLKEHGYTPISFGTKATWTISHYIGTLNQRMVDEKTREKD YNAKTGEFTDEGYVKALEKLQELMPYFNKHVNSVDHEYVRQQFKSGKSAMIYAETAEI KLVEPVNLGMFPFPEISGQKGSSEALTGAPEGFMISSRTKHPKEAMEFLQFLTSKRMG EKLVKDVGKYSAVQGTATEENATAIQREAVQHIVDAKSMVPWFDMDVDVEVADAYLTG VQQMLGGDMTPQQVMKAVQKAAKQVRASAE*" /label="frlO CDS" gene complement(2783324..2784592) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /label="frlO gene" promotor_no_box 2784483..2784583 /Source="Nicolas_upshift_promotors" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2784543 /Source="Nicolas_upshifts" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2784663) /Source="Nicolas_upshifts" /id="D1689" /incds=0 /nref=21 /ntot=141 /MaxReadThrough="7.96763" /MaxDrop="4.994" /score="3.53212058" /energy="-13.8" /TU="U2557" /idTUdmin="U2558" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS complement(2784673..2785659) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12618455, 15556630, 16153181, 18083814, 21347729, 21398478, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructosamine-6-P deglycase" /protein_id="NP_391141.1" /db_xref="EnsemblGenomes-Gn:BSU32610" /db_xref="EnsemblGenomes-Tr:CAB15251" /db_xref="GOA:O32157" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR024713" /db_xref="InterPro:IPR035488" /db_xref="InterPro:IPR035490" /db_xref="PDB:3EUA" /db_xref="SubtiList:BG14002" /db_xref="UniProtKB/Swiss-Prot:O32157" /translation="MSQATAKVNREVQAFLQDLKGKTIDHVFFVACGGSSAIMYPSKY VFDRESKSINSDLYSANEFIQRNPVQLGEKSLVILCSHSGNTPETVKAAAFARGKGAL TIAMTFKPESPLAQEAQYVAQYDWGDEALAINTNYGVLYQIVFGTLQVLENNTKFEQA IEGLDQLQAVYEKALKQEADNAKQFAKAHEKESIIYTMASGANYGVAYSYSICILMEM QWIHSHAIHAGEYFHGPFEIIDESVPFIILLGLDETRPLEERALTFSKKYGKKLTVLD AASYDFTAIDDSVKGYLAPLVLNRVLRSYADELAEERNHPLSHRRYMWKVEY*" /label="frlB CDS" gene complement(2784673..2785659) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /label="frlB gene" upshifts 2785606 /Source="Nicolas_upshifts" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2785609..2785613 /Source="Nicolas_upshift_promotors" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2785702..2785721) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2785715) /Source="Nicolas_upshifts" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2785736..2785743) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2785873) /Source="Nicolas_upshifts" /id="D1690" /incds=0 /nref=116 /ntot=274 /MaxReadThrough="0.87627" /MaxDrop="5.35981" /score="3.53212058" /energy="-13.8" /TU="NA" /idTUdmin="U2558" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2785875..2786249) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excinuclease" /protein_id="NP_391142.1" /db_xref="EnsemblGenomes-Gn:BSU32620" /db_xref="EnsemblGenomes-Tr:CAB15252" /db_xref="GOA:O32158" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR014527" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG14003" /db_xref="UniProtKB/Swiss-Prot:O32158" /translation="MIKIDIPAPNVTITERQQSANDNEPKIKPIHGFIDFHQIPRDKG GIFMFYNIHDELLFVGKARKLRQRIKKHFEDTVSPIKHHRDEVYKIEVCVVDDPMERE IYETYIINTQHSKYNIDKVFFK*" /label="yurQ CDS" gene complement(2785875..2786249) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /label="yurQ gene" upshifts complement(2786313) /Source="Nicolas_upshifts" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2786320..2786331) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2786345..2786351) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2786352..2787470) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 13914427, 16245349, 22271930, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acid oxidase" /protein_id="NP_391143.1" /db_xref="EnsemblGenomes-Gn:BSU32630" /db_xref="EnsemblGenomes-Tr:CAB15253" /db_xref="GOA:O32159" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14004" /db_xref="UniProtKB/Swiss-Prot:O32159" /translation="MKSYIIVGAGILGASTAYHLAKTGARVTVIDRKEPGQATDAAAG IVCPWLSQRRNQDWYQLAKGGARYYKDLIHQLEKDGESDTGYKRVGAISIHTDASKLD KMEERAYKRREDAPEIGDITRLSASETKKLFPILADGYESVHISGAARVNGRALCRSL LSAAEKRGATVIKGNASLLFENGTVTGVQTDTKQFAADAVIVTAGAWANEILKPLGIH FQVSFQKAQIMHFEMTDADTGSWPVVMPPSDQYILSFDNGRIVAGATHENDAGLDDLR VTAGGQHEVLSKALAVAPGLADAAAVETRVGFRPFTPGFLPVVGAVPNVQGLYAANGL GASGLTMGPFLGAELAKLVLGKQTELDLSPYDPAGALA*" /label="dadA CDS" gene complement(2786352..2787470) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /label="dadA gene" promotor_-10 complement(2787495..2787514) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2787501) /Source="Nicolas_upshifts" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2787503..2788113) /Source="Nicolas_S_feature" /locus_tag="new_3353940_3354550_c" /HighExp="G135, H2O2, G180, Paraq, G150, Oxctl, LBGexp, Salt, dia15, Diami" /AntisenseName="yurS" /AntisenseCor="-0.14245591415946501" /AntisenseRegPval="-1.7" /CDS_PredictionProba="0.95340499999999995" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1255" promotor_-35 complement(2787528..2787534) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2787567..2787576 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2787590..2787609 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2787594 /Source="Nicolas_upshifts" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2787607..2787622) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2787611) /Source="Nicolas_upshifts" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2787629..2787633) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2787629..2787775 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type f : factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054592.1" /db_xref="EnsemblGenomes-Gn:BSU32640" /db_xref="EnsemblGenomes-Tr:CAE01466" /db_xref="GOA:Q7WY59" /db_xref="SubtiList:BG14173" /db_xref="UniProtKB/Swiss-Prot:Q7WY59" /translation="MSENRHENEENRRDAAVAKVQNSGNAKVVVSVNTDQDQAQAQSQ DGED*" /label="sspG CDS" gene 2787629..2787775 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /label="sspG gene" CDS 2787775..2788050 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9852018" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391144.1" /db_xref="EnsemblGenomes-Gn:BSU32650" /db_xref="EnsemblGenomes-Tr:CAB15254" /db_xref="SubtiList:BG14005" /db_xref="UniProtKB/Swiss-Prot:O32160" /translation="MNENIIPLNRHTQEIPTTESVIKNSGNSEVHIDIHIDTMPIAFA ILCSALAAKQMTKEEFDMAYTQLREMNRENNSRSSVKQIINQETEEE*" /label="yurS CDS" gene 2787775..2788050 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /label="yurS gene" upshifts complement(2787919) /Source="Nicolas_upshifts" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2787935..2787949) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2787958..2787962) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2788030 /Source="Nicolas_upshifts" /id="D1691" /incds=0 /nref=36 /ntot=86 /MaxReadThrough="1.84089" /MaxDrop="7.4989" /score="15.0184762" /energy="-11" /TU="NA" /idTUdmin="U2560" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2788114..2788497) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10882093, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10882093, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxalase; lactoylbacillithiol lyase" /protein_id="NP_391145.1" /db_xref="EnsemblGenomes-Gn:BSU32660" /db_xref="EnsemblGenomes-Tr:CAB15255" /db_xref="GOA:O32161" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG14006" /db_xref="UniProtKB/Swiss-Prot:O32161" /translation="MKIVVTSIFVQDQDMALEFYTEKLGFIKKEDVPMGKFRWITLVS PDDQDGTELLLEPNEHPAAKEYQKKIFSEGLPATMFGVADIQKEYNRLKEKGVTFTTE PTKMGEVTIAVFDDTCGNLIQIVQK*" /label="glxB CDS" gene complement(2788114..2788497) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /label="glxB gene" S_feature complement(2788498..2788607) /Source="Nicolas_S_feature" /locus_tag="new_3354935_3355044_c" /HighExp="Salt, G180, H2O2, Paraq, G135, G150, LBGexp, LBGstat, dia15, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1256" CDS complement(2788608..2788886) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097781.1" /db_xref="EnsemblGenomes-Gn:BSU32669" /db_xref="EnsemblGenomes-Tr:CAX52687" /db_xref="GOA:C0H3Q8" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Q8" /translation="MNGNKDAIFKALGDSTRRLILDELSERNELTLYELTIRLITKYD LSITRQAIAKHLSVLEDAGLVTSKRKGKYRVLIFNNEPLKNLLKGWIE*" /label="yuzN CDS" gene complement(2788608..2788886) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /label="yuzN gene" promotor_-10 complement(2788884..2788903) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2788908) /Source="Nicolas_upshifts" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2788918..2788925) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2789049..2789155) /Source="Nicolas_S_feature" /locus_tag="new_3355486_3355592_c" /HighExp="Sw, BI, LPhT, C90, BC, M0t45, Gly, Cold, H2O2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.994" /TUlongSig="SigGF" /TUlongPSig="0.999" /label="S1257" downshifts complement(2789092) /Source="Nicolas_upshifts" /id="D1692" /incds=0 /nref=189 /ntot=303 /MaxReadThrough="3.22318" /MaxDrop="7.82118" /score="0.760415296" /energy="-10.1" /TU="U2564" /idTUdmin="U2565" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2789156..2790553) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16109955, 16431905, 16621837, 20097860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16109955, 16431905, 16621837, 20097860; Product type f: factor" /codon_start=1 /transl_table=11 /product="FeS cluster formation scaffold protein" /protein_id="NP_391146.1" /db_xref="EnsemblGenomes-Gn:BSU32670" /db_xref="EnsemblGenomes-Tr:CAB15256" /db_xref="GOA:O32162" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR010231" /db_xref="SubtiList:BG14007" /db_xref="UniProtKB/Swiss-Prot:O32162" /translation="MAKKMPDIGEYKYGFHDKDVSIFRSERGLTKEIVEEISRMKEEP QWMLDFRLKSLEHFYNMPMPQWGGDLNSLNFDEITYYVKPSERSERSWDEVPEEIKQT FDKLGIPEAEQKYLAGVSAQYESEVVYHNMKEDLEAQGIVFKDTDSALKENEDIFREH WAKVIPPTDNKFAALNSAVWSGGSFIYVPKGVKVETPLQAYFRINSENMGQFERTLII VDEEASVHYVEGCTAPVYTTNSLHSAVVEIIVKKGGYCRYTTIQNWANNVYNLVTKRT VCEENATMEWIDGNIGSKLTMKYPACILKGEGARGMTLSIALAGKGQHQDAGAKMIHL APNTSSTIVSKSISKQGGKVTYRGIVHFGRKAEGARSNIECDTLIMDNKSTSDTIPYN EILNDNISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAV EMNRLIKFEMEGSIG*" /label="sufB CDS" gene complement(2789156..2790553) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /label="sufB gene" downshifts 2790351 /Source="Nicolas_upshifts" /id="D1693" /incds=1 /nref=1 /ntot=150 /MaxReadThrough="2.66718" /MaxDrop="3.75483" /score="-4.89805724" /energy="-5" /TU="NA" /idTUdmin="U2560" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS complement(2790574..2791017) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16877383, 20097860, 21236255, 24321018, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16877383, 20097860, 21236255, 24321018, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="iron-sulfur cluster assembly sulfur-transfer protein (Zn(2+)-dependent)" /protein_id="NP_391147.1" /db_xref="EnsemblGenomes-Gn:BSU32680" /db_xref="EnsemblGenomes-Tr:CAB15257" /db_xref="GOA:O32163" /db_xref="InterPro:IPR002871" /db_xref="PDB:1XJS" /db_xref="PDB:2AZH" /db_xref="SubtiList:BG14008" /db_xref="UniProtKB/Swiss-Prot:O32163" /translation="MSFNANLDTLYRQVIMDHYKNPRNKGVLNDSIVVDMNNPTCGDR IRLTMKLDGDIVEDAKFEGEGCSISMASASMMTQAIKGKDIETALSMSKIFSDMMQGK EYDDSIDLGDIEALQGVSKFPARIKCATLSWKALEKGVAKEEGGN*" /label="sufU CDS" gene complement(2790574..2791017) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /label="sufU gene" CDS complement(2791007..2792227) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_391148.1" /db_xref="EnsemblGenomes-Gn:BSU32690" /db_xref="EnsemblGenomes-Tr:CAB15258" /db_xref="GOA:O32164" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR010970" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="PDB:5J8Q" /db_xref="SubtiList:BG14009" /db_xref="UniProtKB/Swiss-Prot:O32164" /translation="MNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKY YNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALS YARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETVT SNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFF ALSSHKMCGPTGVGVLYGKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTP IIAGAIGLGAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTF NLDDVHPHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLV EALQKTKEYFTNVF*" /label="sufS CDS" gene complement(2791007..2792227) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /label="sufS gene" CDS complement(2792227..2793540) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16109955, 16431905, 16621837, 19187533, 20097860, 28839209; Product type f: factor" /codon_start=1 /transl_table=11 /product="Fe-S cluster assembly protein SufD" /protein_id="NP_391149.1" /db_xref="EnsemblGenomes-Gn:BSU32700" /db_xref="EnsemblGenomes-Tr:CAB15259" /db_xref="GOA:O32165" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR011542" /db_xref="SubtiList:BG14010" /db_xref="UniProtKB/Swiss-Prot:O32165" /translation="MTLGTKLSVDQEYLKSFSEKHQEPAWLKNLRLQALEQAEDLPMP KPDKTKITNWNFTNFAKHTVDNEPLSSLEDLTDEVKALIDIENEDKTLYVQRDQTPAH LSLSQELKDKGVIFTDILTAAREHSDLVEKYFMKDGVKVDEHKLTALHAALVNGGAFL YVPKNVQVETPVQAVYVHESNDTALFNHVLIVAEDHSSVTYVENYISTVNPKDAVFNI ISEVITGDNASVTYGAVDNLSSGVTTYVNRRGAARGRDSKIEWALGLMNDGDTISENT TNLYGDGTYGDTKTVVVGRGEQTENFTTQIIHFGKASEGYILKHGVMKDSASSIFNGI GKIEHGASKANAEQESRVLMLSEKARGDANPILLIDEDDVTAGHAASVGRVDPIQLYY LMSRGIPKEEAERLVIYGFLAPVVNELPIEGVKKQLVSVIERKVK*" /label="sufD CDS" gene complement(2792227..2793540) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /label="sufD gene" CDS complement(2793558..2794343) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16431905, 20097860, 28839209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16431905, 20097860, 28839209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur mobilizing ABC protein, ATPase" /protein_id="NP_391150.1" /db_xref="EnsemblGenomes-Gn:BSU32710" /db_xref="EnsemblGenomes-Tr:CAB15260" /db_xref="GOA:P80866" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010230" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14011" /db_xref="UniProtKB/Swiss-Prot:P80866" /translation="MAASTLTIKDLHVEIEGKEILKGVNLEIKGGEFHAVMGPNGTGK STLSAAIMGHPKYEVTKGSITLDGKDVLEMEVDERAQAGLFLAMQYPSEISGVTNADF LRSAINARREEGDEISLMKFIRKMDENMEFLEMDPEMAQRYLNEGFSGGEKKRNEILQ LMMIEPKIAILDEIDSGLDIDALKVVSKGINKMRSENFGCLMITHYQRLLNYITPDVV HVMMQGRVVKSGGAELAQRLEAEGYDWIKQELGIEDETVGQEA*" /label="sufC CDS" gene complement(2793558..2794343) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /label="sufC gene" promotor_-10 complement(2794387..2794406) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2794388) /Source="Nicolas_upshifts" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" promotor_-35 complement(2794420..2794427) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" promotor_-10 complement(2794444..2794463) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2794453) /Source="Nicolas_upshifts" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" S_feature complement(2794455..2794536) /Source="Nicolas_S_feature" /locus_tag="new_3360892_3360973_c" /HighExp="Salt, HiOs, B60, LoTm, T1.0H, Gly, T2.0H, C30, Etha, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1258" promotor_-35 complement(2794479..2794483) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" misc_RNA complement(2794500..2794747) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /product="small regulatory RNA or messenger RNA" /experiment="publication(s) with functional evidences, PMID:18948176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176; Product type n: RNA" /label="bsrI RNA" gene complement(2794500..2794747) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /label="bsrI gene" CDS complement(2794537..2794674) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin antitoxin system" /protein_id="YP_003097782.1" /db_xref="EnsemblGenomes-Gn:BSU32719" /db_xref="EnsemblGenomes-Tr:CAX52688" /db_xref="UniProtKB/Swiss-Prot:C0H3Q9" /translation="MEKAMQLSHGIGYEEYGRRLETRMKVERQRELDYEKSKRISAGA Y*" /label="yuzK CDS" gene complement(2794537..2794674) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /label="yuzK gene" S_feature complement(2794675..2794759) /Source="Nicolas_S_feature" /locus_tag="new_3361112_3361196_c" /HighExp="HiOs, Salt, B60, S5, T1.0H, S8, HiTm, S7, T1.30H, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63415999999999995" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1259" promotor_-10 complement(2794743..2794762) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2794759) /Source="Nicolas_upshifts" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2794761..2794867) /Source="Nicolas_S_feature" /locus_tag="new_3361198_3361304_c" /HighExp="S8, S5, S7, S6, S4, BT, ferm, nit, S3, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1260" promotor_-35 complement(2794778..2794781) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2794868..2795245) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391151.1" /db_xref="EnsemblGenomes-Gn:BSU32720" /db_xref="EnsemblGenomes-Tr:CAB15261" /db_xref="GOA:O32166" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG14012" /db_xref="UniProtKB/Swiss-Prot:O32166" /translation="MEGFSLNQDRGSMQDALKQYKHGLGTFEQKMPLMGRKFNEFTEQ CFAGNSLTEREKQLIALGIAINAQDEYCMIYHTKGCLDQGASEENILEAVSVAAAFGG GAAFSQGVTVVQQCIEEFGNTTH*" /label="yurZ CDS" gene complement(2794868..2795245) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /label="yurZ gene" promotor_-10 complement(2795262..2795273) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-10" upshifts complement(2795268) /Source="Nicolas_upshifts" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="upshifts" promotor_-35 complement(2795287..2795293) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-35" CDS complement(2795330..2796154) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 16109943, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 16109943, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, substrate binding lipoprotein" /protein_id="NP_391152.1" /db_xref="EnsemblGenomes-Gn:BSU32730" /db_xref="EnsemblGenomes-Tr:CAB15262" /db_xref="GOA:O32167" /db_xref="InterPro:IPR004872" /db_xref="PDB:4GOT" /db_xref="SubtiList:BG14013" /db_xref="UniProtKB/Swiss-Prot:O32167" /translation="MKKLFLGALLLVFAGVMAACGSNNGAESGKKEIVVAATKTPHAE ILKEAEPLLKEKGYTLKVKVLSDYKMYNKALADKEVDANYFQHIPYLEQEMKENTDYK LVNAGAVHLEPFGIYSKTYKSLKDLPDGATIILTNNVAEQGRMLAMLENAGLITLDSK VETVDATLKDIKKNPKNLEFKKVAPELTAKAYENKEGDAVFINVNYAIQNKLNPKKDA IEVESTKNNPYANIIAVRKGEEDSAKIKALMEVLHSKKIKDFIEKKYDGAVLPVSE*" /label="metQ CDS" gene complement(2795330..2796154) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /label="metQ gene" downshifts complement(2795338) /Source="Nicolas_upshifts" /id="D1694" /incds=0 /nref=167 /ntot=246 /MaxReadThrough="2.13581" /MaxDrop="6.33517" /score="28.8468637" /energy="-12.6" /TU="NA" /idTUdmin="U2569" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2795487) /Source="Nicolas_upshifts" /id="D1695" /incds=1 /nref=2 /ntot=171 /MaxReadThrough="6.93658" /MaxDrop="2.3341" /score="28.8468637" /energy="-12.6" /TU="U2569" /idTUdmin="U2569" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-35 2795514..2795519 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2795535..2795553 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2795537 /Source="Nicolas_upshifts" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2796168..2796836) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 15849754, 16850406, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 15849754, 16850406, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, permease component" /protein_id="NP_391153.1" /db_xref="EnsemblGenomes-Gn:BSU32740" /db_xref="EnsemblGenomes-Tr:CAB15263" /db_xref="GOA:O32168" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14014" /db_xref="UniProtKB/Swiss-Prot:O32168" /translation="MFEKYFPNVDLTELWNATYETLYMTLISLLFAFVIGVILGLLLF LTSKGSLWQNKAVNSVIAAVVNIFRSIPFLILIILLLGFTKFLVGTILGPNAALPALV IGSAPFYARLVEIALREVDKGVIEAAKSMGAKTSTIIFKVLIPESMPALISGITVTAI ALIGSTAIAGAIGSGGLGNLAYVEGYQSNNADVTFVATVFILIIVFIIQIIGDLITNI IDKR*" /label="metP CDS" gene complement(2796168..2796836) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /label="metP gene" CDS complement(2796829..2797854) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 17038623; Product type t: transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter (ATP-binding protein)" /protein_id="NP_391154.1" /db_xref="EnsemblGenomes-Gn:BSU32750" /db_xref="EnsemblGenomes-Tr:CAB15264" /db_xref="GOA:O32169" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017908" /db_xref="InterPro:IPR018449" /db_xref="InterPro:IPR026253" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14015" /db_xref="UniProtKB/Swiss-Prot:O32169" /translation="MINLQDVSKVYKSKHGDVNAVQNVSLSIKKGEIFGIIGYSGAGK SSLIRLLNGLEKPTSGTVEVAGTKINEVNGRGLRKARHEISMIFQHFNLLWSRTVRDN IMFPLEIAGVKKSERIKRANELIKLVGLEGKEKSYPSQLSGGQKQRVGIARALANNPK VLLCDEATSALDPQTTDSILDLLSDINERLGLTIVLITHEMHVIRKICNRVAVMENGK VVEEGEVLDVFKNPKEQMTKRFVQQVTEPEETKETLQHLLDDTASGKMVQLTFVGESA EQPLITEMIRNFNVSVNILQGKISQTKDGAYGSLFIHIDGDEEEVQNVIRFINDKQVK AEVITNV*" /label="metN CDS" gene complement(2796829..2797854) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /label="metN gene" S_feature complement(2797855..2797959) /Source="Nicolas_S_feature" /locus_tag="new_3364292_3364396_c" /HighExp="MG 5, MG t5, MG 10, BMM, MG-0.2, GM 25, MG-0.1, MG 15, M9-exp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1261" misc_RNA complement(2797960..2798066) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswH RNA" gene complement(2797960..2798066) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /label="mswH gene" downshifts 2798029 /Source="Nicolas_upshifts" /id="D1696" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="1.54417" /MaxDrop="5.51028" /score="-1.70178746" /energy="-11.2" /TU="NA" /idTUdmin="U2568" /TUdmin=2420 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2798093..2798112) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2798105) /Source="Nicolas_upshifts" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2798107..2798180) /Source="Nicolas_S_feature" /locus_tag="new_3364544_3364617_c" /HighExp="M9-stat, S2, LoTm, T5.0H, HiOs, B60, S3, T3.30H, LPhT, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1262" promotor_-35 complement(2798128..2798135) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2798181..2798525) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391155.1" /db_xref="EnsemblGenomes-Gn:BSU32760" /db_xref="EnsemblGenomes-Tr:CAB15265" /db_xref="InterPro:IPR003033" /db_xref="InterPro:IPR036527" /db_xref="SubtiList:BG14016" /db_xref="UniProtKB/Swiss-Prot:O32170" /translation="MEKAEVLEDEYQHLFLKPLLNASTLLITFQGEAEALTVSINEQG EMKKVSPPQTSNLTFYGNQTEIIDLLHGDISLQHLIQSGSLKVKGSFRALLKLEAILW LTNGFFQRILKN*" /label="yusD CDS" gene complement(2798181..2798525) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /label="yusD gene" S_feature complement(2798526..2798631) /Source="Nicolas_S_feature" /locus_tag="new_3364963_3365068_c" /HighExp="LPhT, HiOs, M9-stat, dia5, T2.0H, Diami, T1.30H, T0.30H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA, SigA" /TUshortPSig="1, 0.996, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S1263" CDS complement(2798632..2798952) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_391156.1" /db_xref="EnsemblGenomes-Gn:BSU32770" /db_xref="EnsemblGenomes-Tr:CAB15266" /db_xref="GOA:O32171" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14017" /db_xref="UniProtKB/Swiss-Prot:O32171" /translation="MKELQEHELDHIEDDVYLLYLYTPFCGTCQLASKMLTVVKEMLP DVAFYQNNVNYSPTFAKAYQIESVPCFLLFKGGKMVERGYAFHSVSYLYELIKQKSSS ASHL*" /label="yusE CDS" gene complement(2798632..2798952) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /label="yusE gene" CDS complement(2798954..2799394) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12794188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease" /protein_id="NP_391157.1" /db_xref="EnsemblGenomes-Gn:BSU32780" /db_xref="EnsemblGenomes-Tr:CAB15267" /db_xref="GOA:O32172" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG14018" /db_xref="UniProtKB/Swiss-Prot:O32172" /translation="MLAVNFTAFFYNLNISNLTRQVNKMKMDELEKVMIVEGKSDKEK IESVLNEPMRIICTNGTISQLRLEELADELYDKDVYILVDADESGEKLRKQLKREFNE ACHLHVDRAYKEVAAAPRHHIASVLLRANLNVHTIFLERKSRGV*" /label="yusF CDS" gene complement(2798954..2799394) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /label="yusF gene" CDS complement(2799394..2799630) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391158.1" /db_xref="EnsemblGenomes-Gn:BSU32790" /db_xref="EnsemblGenomes-Tr:CAB15268" /db_xref="InterPro:IPR020140" /db_xref="SubtiList:BG14019" /db_xref="UniProtKB/Swiss-Prot:O32173" /translation="MAFDKQKLDVTNDVTGRFQNGRLSLYHDNEMIGQMTSMNEYELK SGYSFENEKFYKTADVVSGDDAKYVDCDYENGWC*" /label="yusG CDS" gene complement(2799394..2799630) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /label="yusG gene" downshifts complement(2799406) /Source="Nicolas_upshifts" /id="D1697" /incds=0 /nref=35 /ntot=245 /MaxReadThrough="6.00162" /MaxDrop="3.9147" /score="-1.53913693" /energy="-11" /TU="U2570,U2571,U2572" /idTUdmin="U2574" /TUdmin=723 /isTUend="FALSE" /label="downshifts" upshifts complement(2799645) /Source="Nicolas_upshifts" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2799650..2799661) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2799676..2799682) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2799686..2800069) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 20882995, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine cleavage system protein H (lipoyl acceptor protein)" /protein_id="NP_391159.1" /db_xref="EnsemblGenomes-Gn:BSU32800" /db_xref="EnsemblGenomes-Tr:CAB15269" /db_xref="GOA:O32174" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR002930" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR017453" /db_xref="InterPro:IPR033753" /db_xref="SubtiList:BG14020" /db_xref="UniProtKB/Swiss-Prot:O32174" /translation="MSIPKDLRYSGEHEWVKVEGEKARIGITHFAQSELGDIVFVELP EVGAEIKADEPFGSVESVKTVSELYAPINGTVVEVNEDLDDSPEFVNESPYEKAWMIV VEPSDASEIEKLMTAEQYEEMTQED*" /label="gcvH CDS" gene complement(2799686..2800069) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /label="gcvH gene" promotor_-10 complement(2800096..2800115) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-10" upshifts complement(2800107) /Source="Nicolas_upshifts" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="upshifts" promotor_-35 complement(2800128..2800135) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-35" CDS complement(2800136..2800492) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /EC_number="1.20.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with thioredoxin domain and regulator domain" /protein_id="NP_391160.1" /db_xref="EnsemblGenomes-Gn:BSU32810" /db_xref="EnsemblGenomes-Tr:CAB15270" /db_xref="GOA:O32175" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14021" /db_xref="UniProtKB/Swiss-Prot:O32175" /translation="MSLTFYWYPKCGTCRKAKKWLEEHGKEINEIHIAEQPPSKEELK ALYEKSGLDLKKFFNTSGMKYRELNLKEKLYHMSEDEQLELLASDGMLIKRPLTTDGE KVTVGFKEDQFEENWA*" /label="yusI CDS" gene complement(2800136..2800492) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /label="yusI gene" promotor_-10 complement(2800515..2800534) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-10" upshifts complement(2800525) /Source="Nicolas_upshifts" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="upshifts" promotor_-35 complement(2800548..2800553) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-35" CDS complement(2800603..2802387) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase (FAD dependent)" /protein_id="NP_391161.1" /db_xref="EnsemblGenomes-Gn:BSU32820" /db_xref="EnsemblGenomes-Tr:CAB15271" /db_xref="GOA:O32176" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG14022" /db_xref="UniProtKB/Swiss-Prot:O32176" /translation="MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDY IEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKF SRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDAL GAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVST GPEEKKMGIKGSSTRTLILDQAEVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGA SKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMS QFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVE RAYRDSRINRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPG SGVLEQEKYIVKQAKKIALFAAGLAAQKYGKAIDREQEILVNVADIVSNVYAMESAVL RTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMMLSALRK LTRVTPKNVIQKKREAAAGIFEAEKYTV*" /label="fadE CDS" gene complement(2800603..2802387) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /label="fadE gene" downshifts complement(2800613) /Source="Nicolas_upshifts" /id="D1698" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="4.78872" /MaxDrop="6.88218" /score="31.8022607" /energy="-16.4" /TU="U2574" /idTUdmin="U2576" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2802402..2803577) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /EC_number="2.3.1.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acyltransferase" /protein_id="NP_391162.1" /db_xref="EnsemblGenomes-Gn:BSU32830" /db_xref="EnsemblGenomes-Tr:CAB15272" /db_xref="GOA:O32177" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG14023" /db_xref="UniProtKB/Swiss-Prot:O32177" /translation="MKEAVIVSGARTPVGKAKKGSLATVRPDDLGAICVKETLKRAGG YEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPYTVPAITVNRYCSSGLQSIAYAAE KIMLGAYDTAIAGGAESMSQVPMMGHVTRPNLALAEKAPEYYMSMGHTAEQVAKKYGV SREDQDAFAVRSHQNAAKALAEGKFKDEIVPVEVTVTEIGEDHKPMEKQFVFSQDEGV RPQTTADILSTLRPAFSVDGTVTAGNSSQTSDGAAAVMLMDREKADALGLAPLVKFRS FAVGGVPPEVMGIGPVEAIPRALKLAGLQLQDIGLFELNEAFASQAIQVIRELGIDEE KVNVNGGAIALGHPLGCTGTKLTLSLIHEMKRRNEQFGVVTMCIGGGMGAAGVFELC* " /label="fadA CDS" gene complement(2802402..2803577) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /label="fadA gene" CDS complement(2803588..2805957) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /EC_number="1.1.1.35" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17189250, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase" /protein_id="NP_391163.2" /db_xref="EnsemblGenomes-Gn:BSU32840" /db_xref="EnsemblGenomes-Tr:CAB15273" /db_xref="GOA:O32178" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14024" /db_xref="UniProtKB/Swiss-Prot:O32178" /translation="MHKHIRKAAVLGSGVMGSGIAAHLANIGIPVLLLDIVPNDLTKE EEKKGLTKDSSEVRSRLSRQAMKKLLKQKPAPLTSAKNTSYITPGNLEDDAEKLKEAD WIIEVVVENLEVKKKIFALVDEHRKTGSIVSSNTSGISVQEMAEGRSDDFKAHFLGTH FFNPARYLKLLEIIPIKETDPDILKFMTAFGENVLGKGVVTAKDTPNFIANRIGTYGL LVTVQEMLKGGYQVGEVDSITGPLIGRPKSATFRTLDVVGLDTFAHVARNVYDKADGD EKEVFRIPSFMNDMLEKGWIGSKAGQGFYKKEGKTIYELDPVTLTYGERTKMKSPALE AAKQAKGTKAKMKALIYSDDRAGRLLWNITSQTLLYSAELLGEIADDIHAIDQAMKWG FGWELGPFEMWDAIGLKQSAEKLEQLGADMPGWIKEMLDKGNETFYIKENGTVFYYDR GEYRAVKENKKRIHLQALKETKGVIAKNSGASLIDLGDDVALLEFHSKSNAIGLDIIQ MIHKGLEETERNYKGLVIGNQGKNFCVGANLAMILMEVQDDNFLEVDFVIRRFQETMM KIKYSAKPVVAAPFGMTLGGGTEACLPAARIQAASEAYMGLVESGVGLIPGGGGNKEL YINHLRRGHDPMNAAMKTFETIAMAKVSASAQEAREMNILKETDQISVNQDHLLYDAK QLAASLYDTGWRPPVKEKVKVPGETGYAALLLGAEQMKLSGYISEHDFKIAKKLAYVI AGGKVPFGTEVDEEYLLEIEREAFLSLSGEAKSQARMQHMLVKGKPLRN*" /label="fadN CDS" gene complement(2803588..2805957) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /label="fadN gene" promotor_-35 2805376..2805381 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2805396..2805414 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2805399 /Source="Nicolas_upshifts" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2806025..2806044) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-10" upshifts complement(2806028) /Source="Nicolas_upshifts" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="upshifts" S_feature complement(2806036..2806302) /Source="Nicolas_S_feature" /locus_tag="new_3372473_3372739_c" /HighExp="S8, S6, S7, BT, B36, G/S, B60, S5, Pyr, S3" /AntisenseName="yuzL" /AntisenseCor="0.77564732124057401" /AntisenseRegPval="-54.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1264" promotor_-35 complement(2806058..2806065) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-35" promotor_-35 2806083..2806089 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2806104..2806115 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2806126 /Source="Nicolas_upshifts" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="upshifts" CDS 2806132..2806278 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17189250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097783.1" /db_xref="EnsemblGenomes-Gn:BSU32849" /db_xref="EnsemblGenomes-Tr:CAX52689" /db_xref="InterPro:IPR025625" /db_xref="UniProtKB/Swiss-Prot:C0H3R0" /translation="MVREKKNPSSAAVSAASVKGDAGPTQHYGGGKRTSQNQQYKKHN MGQS*" /label="yuzL CDS" gene 2806132..2806278 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /label="yuzL gene" S_feature 2806279..2807305 /Source="Nicolas_S_feature" /locus_tag="new_3372716_3373742" /HighExp="S8, S5, S7, S4, S6, nit, ferm, T5.0H, S3, LoTm" /AntisenseName="fadM" /AntisenseCor="0.80952501049450498" /AntisenseRegPval="-63" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1265" CDS complement(2806303..2807211) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /EC_number="1.5.5.2" /function="3.2: Degradation" /experiment="publication(s) with functional evidences, PMID:17189250, 17536821, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 17536821, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline dehydrogenase 1" /protein_id="NP_391164.1" /db_xref="EnsemblGenomes-Gn:BSU32850" /db_xref="EnsemblGenomes-Tr:CAB15274" /db_xref="GOA:O32179" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG14025" /db_xref="UniProtKB/Swiss-Prot:O32179" /translation="MLRHVFLFLSQNKTLTKFAKAYGTRLGARRFVAGDTIESAVKTV KRLNRSGLCATIDYLGEYAASEKEANQVAEECKKAIQAIAEHQLNSELSLKLTSIGLD LSEELALTHLRAILSVAKQYDVAVTIDMEDYSHYEQTLSIYRQCKQEFEKLGTVIQAY LYRAAEDIRKMRDLKPNLRLVKGAYKESAAVAFPDKRGTDLHFQSLIKLQLLSGNYTA VATHDDDIIAFTKQLVAEHQIPASQFEFQMLYGIRPERQKELAKEGYRMRVYVPYGTD WFSYFMRRIAERPANAAFVLKGILKK*" /label="putM CDS" gene complement(2806303..2807211) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /label="putM gene" S_feature complement(2807212..2807734) /Source="Nicolas_S_feature" /locus_tag="new_3373649_3374171_c" /HighExp="S8, S6, S7, BT, B36, B60, G/S, Pyr, S5, SMMPr" /AntisenseName="yuzM" /AntisenseCor="0.77827902986544495" /AntisenseRegPval="-55.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1266" CDS 2807306..2807551 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097784.1" /db_xref="EnsemblGenomes-Gn:BSU32859" /db_xref="EnsemblGenomes-Tr:CAX52690" /db_xref="InterPro:IPR012347" /db_xref="UniProtKB/Swiss-Prot:C0H3R1" /translation="MDNQQQSQMPPSVISTKDHLYLNDMLNWNLLAMKKAHFMAQQCQ DQTLKQELDRVGHMHHDHYQRILKHLQPGQQQSGYIQ*" /label="yuzM CDS" gene 2807306..2807551 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /label="yuzM gene" CDS 2807564..2807896 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat-like protein" /protein_id="NP_391165.1" /db_xref="EnsemblGenomes-Gn:BSU32860" /db_xref="EnsemblGenomes-Tr:CAB15275" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG14026" /db_xref="UniProtKB/Swiss-Prot:O32180" /translation="MNQQNQKISNPQTPVPTTSEMNDRDFVNELLTTEKYMTTAYCTA LHEFSHESLYQDIQSIFDESQKAQRKLYDLMFQYGWYSVEAEDSQKLQQSYQKFQQTI QQQSPYQQ*" /label="yusN CDS" gene 2807564..2807896 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /label="yusN gene" promotor_-10 complement(2807717..2807736) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2807734) /Source="Nicolas_upshifts" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2807750..2807759) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2807885 /Source="Nicolas_upshifts" /id="D1699" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="2.684" /MaxDrop="5.38418" /score="9.88876972" /energy="-10.2" /TU="NA" /idTUdmin="U2575" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2807957..2807964 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2807978..2807997 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2807989 /Source="Nicolas_upshifts" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="upshifts" CDS 2808055..2808522 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12923086, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923086, 19286808; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, low level antibiotic resistance)" /protein_id="NP_391166.1" /db_xref="EnsemblGenomes-Gn:BSU32870" /db_xref="EnsemblGenomes-Tr:CAB15276" /db_xref="GOA:O32181" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1S3J" /db_xref="SubtiList:BG14027" /db_xref="UniProtKB/Swiss-Prot:O32181" /translation="MKSADQLMSDIQLSLQALFQKIQPEMLESMEKQGVTPAQLFVLA SLKKHGSLKVSEIAERMEVKPSAVTLMADRLEQKNLIARTHNTKDRRVIDLSLTDEGD IKFEEVLAGRKAIMARYLSFLTEEEMLQAAHITAKLAQAAETDEKQNMKRGNG*" /label="mdtR CDS" gene 2808055..2808522 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /label="mdtR gene" CDS 2808519..2810144 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19286808; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_391167.1" /db_xref="EnsemblGenomes-Gn:BSU32880" /db_xref="EnsemblGenomes-Tr:CAB15277" /db_xref="GOA:O32182" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14028" /db_xref="UniProtKB/Swiss-Prot:O32182" /translation="MKMSKEGKQSKRTLLITGLIIAMFFSALDGTIVGTAMPKIVGDL GGLSMMTWLTTAYLLTSTTIVPIAGKLADLLGRRIVYVSGLIIFMAASALCGMANNMT ELIIFRGLQGIGGGIMMPMAMIVIGDLFTGKQRAKFQGVFGAIYGLASVIGPQIGGWI VDSLNWKWVFYINLPVGIIAVIFIARGLQGRQQTGPINFDIAGIFTMIVGVVSLLLAL SFGGKDYAWDSWQILGLFALALIGIVSFIIVESKAKEPILPMYLFKNRTFTFLNLIGF FMSIGMFGAITFVPFFMQGIVGVSASESGTIMTPMMISMIITSIIGGQLVYKIGIKPQ IITGMLVMAGGFLLLTTLDLDTSKLVATSFMAIIGLGMGLVMPILTLALQESFSKEEL GVVTSSSQFFRSIGGTFGITMLGAVMNARSGNLLTDKLVPYLDSLPAQASSFAAQLKG MIDTNPQGLLQSLFSPDAVKQIPAAFSSHIVPILKTSLMDSLHSVFYTGLIFIAVGAV FTLFLKPIKLSNKKAEDQQEKEKAAKAVESPSH*" /label="mdtP CDS" gene 2808519..2810144 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /label="mdtP gene" downshifts 2810129 /Source="Nicolas_upshifts" /id="D1700" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="0.3188" /MaxDrop="5.64223" /score="42.0555168" /energy="-17.7" /TU="NA" /idTUdmin="U2577" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2810180..2810563) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25219626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydratase of unidentified specificity (tautomerase superfamily)" /protein_id="NP_391168.1" /db_xref="EnsemblGenomes-Gn:BSU32890" /db_xref="EnsemblGenomes-Tr:CAB15278" /db_xref="GOA:O32183" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG14029" /db_xref="UniProtKB/Swiss-Prot:O32183" /translation="MPFVQIHLRSGRSEVWLQKLSRTIHQSMIEEINVPEDDYFQVIR QYEKSEFFYDPFYLQVERTDELIYIHFTLKQSRTTEQKKALYRSIASRIHSELGVRKE DVFIMLAGNQDEDWSFGNGRAQMIE*" /label="yusQ CDS" gene complement(2810180..2810563) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /label="yusQ gene" CDS complement(2810582..2810971) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15294834; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_391169.1" /db_xref="EnsemblGenomes-Gn:BSU32900" /db_xref="EnsemblGenomes-Tr:CAB15279" /db_xref="GOA:O32184" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14030" /db_xref="UniProtKB/Swiss-Prot:O32184" /translation="MKGMFFCARAVVPFMKKSKDGAIVNVGSIAGITGAGSSMPYAVS KSAVHGLTKSLAHALAPEIRVSGVAPGAVATRWWAGREEKMKSMIGSLLLQCIAEPDD VAKLICSLIEQESLTGQIITIDSGQTL*" /label="yusR CDS" gene complement(2810582..2810971) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /label="yusR gene" CDS complement(2810993..2811322) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved enzyme of unknown function" /protein_id="NP_391170.1" /db_xref="EnsemblGenomes-Gn:BSU32910" /db_xref="EnsemblGenomes-Tr:CAB15280" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14031" /db_xref="UniProtKB/Swiss-Prot:O32185" /translation="MNVLNKIALVTGGGTGIGKAASMELAKRGAIVAVNYSRSQSEAE ETVEMIQKAGGQAFAIQADVSKNSDVQDMIQAIVNTHGTVDILVNNASITRHIPMDDL EAATEDV*" /label="yusS CDS" gene complement(2810993..2811322) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /label="yusS gene" promotor_-10 complement(2811357..2811376) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2811364..2811371 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2811371) /Source="Nicolas_upshifts" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2811386..2811405 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2811390..2811397) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2811396 /Source="Nicolas_upshifts" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="upshifts" CDS 2811456..2812343 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591, 17526699, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591, 17526699, 27965289; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown specificity(LysR family)" /protein_id="NP_391171.1" /db_xref="EnsemblGenomes-Gn:BSU32920" /db_xref="EnsemblGenomes-Tr:CAB15281" /db_xref="GOA:O32186" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14032" /db_xref="UniProtKB/Swiss-Prot:O32186" /translation="MESGDLRVFQMVAREGTITKAALQLGYVQSNVTARIQQLEAELG TTLFLRHNRGMTLSASGKLLLDYANKIIGLLDEASKALSSSAEPSGPLMIGCTQTTAA VRLPKLLASYYEEHPNVQLSLTTGHTQFLLDKVLRYELDGAFIGCECHHPELESYPAF EEEPVVVSAASVPDVEEAITKPILVYSTGCSYRETLEKWLRSVGVTQPVIMEFGTLEA IIGGVTAGLGISLLPRTVVQKHEAEGSIRLYPLPEALSQMKTEFIVRKDSFISSALRT FMDSFTPVKTAESQKSSLL*" /label="yusT CDS" gene 2811456..2812343 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /label="yusT gene" CDS complement(2812363..2812650) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22078549" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391172.1" /db_xref="EnsemblGenomes-Gn:BSU32930" /db_xref="EnsemblGenomes-Tr:CAB15282" /db_xref="InterPro:IPR020393" /db_xref="SubtiList:BG14033" /db_xref="UniProtKB/Swiss-Prot:O32187" /translation="MRKLLAVFSKGRWKMEQKLQEQLDGLLEKYTELLLGETNDELKE EVKQWILYTHIAKSMPPLAKHWNATYPDAKQGIKEIIQHIKELNEAHRNKQ*" /label="yusU CDS" gene complement(2812363..2812650) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /label="yusU gene" downshifts complement(2812375) /Source="Nicolas_upshifts" /id="D1701" /incds=0 /nref=113 /ntot=280 /MaxReadThrough="1.05563" /MaxDrop="5.97768" /score="17.1690128" /energy="-13.2" /TU="NA" /idTUdmin="U2580" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2812675..2813502) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 24847778, 25288929; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III)-siderophore transporter (ATP binding component)" /protein_id="NP_391173.1" /db_xref="EnsemblGenomes-Gn:BSU32940" /db_xref="EnsemblGenomes-Tr:CAB15283" /db_xref="GOA:O32188" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14034" /db_xref="UniProtKB/Swiss-Prot:O32188" /translation="MGMSAISTETLSLGYGDAVIIDELNLTIPKGEITVFIGSNGCGK STLLRSLARLMKPRGGSVLLEGRAIAKLPTKEVAKELAILPQGPSAPEGLTVHQLVKQ GRYPYQNWLKQWSKEDEEAVERALKATKLEDMADRAVDSLSGGQRQRAWIAMTLAQET DIILLDEPTTYLDMTHQIEILDLLFELNEKEDRTIVMVLHDLNLACRYAHHLVAIKDK RIYAEGRPEEVITCDLVQNVFSMNCQVTQDPLFGTPLCIPHGRGRCIVQEAAFTSHG* " /label="feuV CDS" gene complement(2812675..2813502) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /label="feuV gene" downshifts complement(2812691) /Source="Nicolas_upshifts" /id="D1702" /incds=0 /nref=2 /ntot=77 /MaxReadThrough="5.36684" /MaxDrop="3.19022" /score="11.3999731" /energy="-19.8" /TU="U2580" /idTUdmin="U2581" /TUdmin=220 /isTUend="FALSE" /label="downshifts" S_feature complement(2813503..2813640) /Source="Nicolas_S_feature" /locus_tag="new_3379940_3380077_c" /HighExp="T-5.40H, Paraq, H2O2, GM-0.2, HiOs, GM 5, dia15, GM 25, T-3.40H, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1267" promotor_-10 complement(2813625..2813644) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2813640) /Source="Nicolas_upshifts" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2813660..2813663) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2813720..2814157) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26497467; Product type m : membrane component" /codon_start=1 /transl_table=11 /product="spore lipoprotein" /protein_id="NP_391174.1" /db_xref="EnsemblGenomes-Gn:BSU32950" /db_xref="EnsemblGenomes-Tr:CAB15284" /db_xref="InterPro:IPR025623" /db_xref="SubtiList:BG14035" /db_xref="UniProtKB/Swiss-Prot:O32189" /translation="MHLIRAAGAVCLAVVLIAGCRFNEDQHQAEGENTAVTQLKSVPY SNFSLRVSYGDGEHNRYEGIYTKNGTQEKAEIQDKLSGVNQEGEEALDEMKMILSELS VTDQMAETEVIHSVLAAFNLDSHYDHIDLKLKLKDGSIREIKK*" /label="cotNW CDS" gene complement(2813720..2814157) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /label="cotNW gene" promotor_-10 complement(2814181..2814199) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-10" upshifts complement(2814187) /Source="Nicolas_upshifts" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="upshifts" promotor_-35 complement(2814215..2814220) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-35" CDS complement(2814267..2815775) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; C-terminal part of YusY" /db_xref="SubtiList:BG14037" /translation="GLMNRLSADFQSSLVTLDHKLVDINQDVWNELLTKPGLRDVSYI LNERRQRVAEKLSPGKEKLIGNLAVDGYHAWSDLYNMVVGKMTIPYEENGENKQLSVG QAENMMDHQDRTVRKTVYERFRQAWESKQDIFSSTLNHLAGFRLETYKARGWENVLKE PLQINRMKKETLDTMWQVITENKKPFVQFLNRKASMLGLEKLSWYDVEAPIGSDGKVY SYDEAANIITSQFSTFGKKLSSFTEKAFRDGWIEAEDRSGKRVGGFCTSFPDSGESRI FMTFSGSASNVSTLAHELGHAFHQEAMLNVRPLNRSYAMNVAETASTFAEMIVADATV QQAETREEKLVLLEDKVQRSVAFFMNIHARFLFETRFYEERKRGVVPASRLNELMEEA QREAYCNALEEYHPLFWASKLHFHITRVPFYNFPYTFGYLFSLGIYALALEEKDTFEE KYMALLRDTASMTVEDLAMKHLGADITKRDFWENAIKLAVRDAETFLQMTES*" /label="yusYc CDS" gene complement(2814267..2815775) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /pseudo /label="yusYc gene" downshifts complement(2814288) /Source="Nicolas_upshifts" /id="D1703" /incds=0 /nref=125 /ntot=240 /MaxReadThrough="2.57385" /MaxDrop="6.5698" /score="6.83314975" /energy="-12" /TU="NA" /idTUdmin="U2582" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(2815766..2816062) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; N-terminal part of YusY" /translation="MALQGVGQRWDLDSFFKGGSQSEEFKGYIEKLSQSLRAFQDRTD AFQVPESPEEAEGLTALLDLFEQTSVKLQQAGAFVACLQAQNINDQKAIEHQAS*" /label="yusYn CDS" gene complement(2815766..2816062) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /pseudo /label="yusYn gene" promotor_-10 complement(2816085..2816104) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2816101) /Source="Nicolas_upshifts" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2816119..2816122) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2816139..2816144 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2816156..2816175 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2816156 /Source="Nicolas_upshifts" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="upshifts" CDS 2816196..2817038 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative short-chain acyl dehydrogenase" /protein_id="NP_391177.1" /db_xref="EnsemblGenomes-Gn:BSU32980" /db_xref="EnsemblGenomes-Tr:CAB15287" /db_xref="GOA:P37959" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10863" /db_xref="UniProtKB/Swiss-Prot:P37959" /translation="MNKKIAIVTGASSGFGLLAAVKLARSFFVIATSRQPEKAEQLRE LAAAHNVSDSIHITALDVTDEQSIVSFGKAVSAYAPIDLLVNNAGTAYGGFIEDVPME HFRQQFETNVFGVIHVTKTVLPYIRKHGGAKIINVSSISGLTGFPALSPYVSSKHALE GFSESLRIELLPFGIETALIEPGSYKTSIWSTSLSNFMSVPADDSAYHQYYKKILSYV QKNGEESGDPQEVADLIYQLATKQHIKNLRYPIGKGIKLTLLFRSLFPWSAWESILKK KLFS*" /label="yusZ CDS" gene 2816196..2817038 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /label="yusZ gene" promotor_-35 2816568..2816574 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-35" promotor_-10 2816589..2816600 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-10" upshifts 2816597 /Source="Nicolas_upshifts" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="upshifts" promotor_-35 2817065..2817072 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2817081 /Source="Nicolas_upshifts" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2817084..2817103 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2817128..2817589 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 8709848, 21057011, 22194458, 24123749, 28434086" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 8709848, 21057011, 22194458, 24123749, 28434086; Product type f : factor" /codon_start=1 /transl_table=11 /product="metalloregulation DNA-binding stress protein" /protein_id="NP_391178.1" /db_xref="EnsemblGenomes-Gn:BSU32990" /db_xref="EnsemblGenomes-Tr:CAB15288" /db_xref="GOA:P37960" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="PDB:2CHP" /db_xref="SubtiList:BG10864" /db_xref="UniProtKB/Swiss-Prot:P37960" /translation="MKTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFF TLHEKFEELYDHAAETVDTIAERLLAIGGQPVATVKEYTEHASITDGGNETSASEMVQ ALVNDYKQISSESKFVIGLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG*" /label="mrgA CDS" gene 2817128..2817589 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /label="mrgA gene" downshifts 2817565 /Source="Nicolas_upshifts" /id="D1704" /incds=0 /nref=234 /ntot=274 /MaxReadThrough="1.7919" /MaxDrop="8.26581" /score="36.5549876" /energy="-13.3" /TU="NA" /idTUdmin="U2583" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2817633..2819009) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423; Product type f: factor" /codon_start=1 /transl_table=11 /product="protease-associated chaperone for the extracytoplasmic folding and quality control of exported proteins" /protein_id="NP_391180.2" /db_xref="EnsemblGenomes-Gn:BSU33000" /db_xref="EnsemblGenomes-Tr:CAB15290" /db_xref="GOA:Q9R9I1" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14155" /db_xref="UniProtKB/Swiss-Prot:Q9R9I1" /translation="MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSY EAGRQETASALEMEKQETAVKKEKKRRAAWLSPILGGIIGGGLMLGIAPYLPSDQNQA TETASANKQVQSDNFTTAPITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSS SESESGTGSGVIFKKDSDKAYIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDL AVLEISGKNVKKVASFGDSSQLRTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVD TTQGTVEMNVLQTDAAINPGNSGGPLINASGQVIGINSLKVSESGVESLGFAIPSNDV EPIVDQLLQNGKVDRPFLGVQMIDMSQVPETYQENTLGLFGDQLGKGVYVKEVQANSP AEKAGIKSEDVIVKLNGKDVESSADIRQILYKDLKVGDKTTIQVLRKGKTKTLNATLT KQTESSSS*" /label="htrB CDS" gene complement(2817633..2819009) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /label="htrB gene" downshifts complement(2817641) /Source="Nicolas_upshifts" /id="D1705" /incds=0 /nref=206 /ntot=257 /MaxReadThrough="1.84997" /MaxDrop="6.39104" /score="17.1953741" /energy="-11.2" /TU="U2586" /idTUdmin="U2586" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2819010..2819181) /Source="Nicolas_S_feature" /locus_tag="new_3385447_3385618_c" /HighExp="SMMPr, T-0.40H, T-1.10H, M9-tran, T-1.40H, T1.0H, T0.30H, T1.30H, Etha, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67259999999999998" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1268" promotor_-10 complement(2819162..2819181) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2819181) /Source="Nicolas_upshifts" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2819192..2819199) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2819242..2819261) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-10" misc_feature 2819252..2819271 /Source="Nicolas_upshift_promotors" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2819254 /Source="Nicolas_upshifts" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2819260) /Source="Nicolas_upshifts" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="upshifts" S_feature complement(2819262..2820325) /Source="Nicolas_S_feature" /locus_tag="new_3385699_3386762_c" /HighExp="T1.0H, T0.30H, T1.30H, C30, T2.0H, G135, G180, T2.30H, ferm, G150" /AntisenseName="cssR" /AntisenseCor="0.115381389160342" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1269" promotor_-35 complement(2819276..2819283) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-35" CDS 2819287..2819964 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type r: regulator" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component response regulator" /protein_id="NP_391181.1" /db_xref="EnsemblGenomes-Gn:BSU33010" /db_xref="EnsemblGenomes-Tr:CAB15291" /db_xref="GOA:O32192" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14131" /db_xref="UniProtKB/Swiss-Prot:O32192" /translation="MSYTIYLVEDEDNLNELLTKYLENEGWNITSFTKGEDARKKMTP SPHLWILDIMLPDTDGYTLIKEIKAKDPDVPVIFISARDADIDRVLGLELGSNDYISK PFLPRELIIRVQKLLQLVYKEAPPVQKNEIAVSSYRVAEDAREVYDENGNIINLTSKE FDLLLLFIHHKGHPYSREDILLKVWGHDYFGTDRVVDDLVRRLRRKMPELKVETIYGF GYRMMSS*" /label="cssR CDS" gene 2819287..2819964 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /label="cssR gene" CDS 2819961..2821316 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component sensor histidine kinase" /protein_id="NP_391182.2" /db_xref="EnsemblGenomes-Gn:BSU33020" /db_xref="EnsemblGenomes-Tr:CAB15292" /db_xref="GOA:O32193" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14132" /db_xref="UniProtKB/Swiss-Prot:O32193" /translation="MKNKPLAFQIWVVISGILLAISILLLVLFSNTLRDFFTNETYTT IENEQHVLTEYRLPGSIERRYYSEEATAPTTVRSVQHVLLPENEEASSDKDLSILSSS FIHKVYKLADKQEAKKKRYSADVNGEKVFFVIKKGLSVNGQSAMMLSYALDSYRDDLA YTLFKQLLFIIAVVILLSWIPAIWLAKYLSRPLVSFEKHVKRISEQDWDDPVKVDRKD EIGKLGHTIEEMRQKLVQKDETERTLLQNISHDLKTPVMVIRGYTQSIKDGIFPKGDL ENTVDVIECEALKLEKKIKDLLYLTKLDYLAKQKVQHDMFSIVEVTEEVIERLKWARK ELSWEIDVEEDILMPGDPEQWNKLLENILENQIRYAETKIEISMKQDDRNIVITIKND GPHIEDEMLSSLYEPFNKGKKGEFGIGLSIVKRILTLHKASISIENDKTGVTYRIAVP K*" /label="cssS CDS" gene 2819961..2821316 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /label="cssS gene" S_feature complement(2820415..2821343) /Source="Nicolas_S_feature" /locus_tag="new_3386852_3387780_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, ferm, C30, LPhT, T-1.10H, Lbstat" /AntisenseName="cssS" /AntisenseCor="0.27217686232372901" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigD, SigH, SigA" /TUshortPSig="1, 0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1270" downshifts 2821284 /Source="Nicolas_upshifts" /id="D1706" /incds=0 /nref=61 /ntot=203 /MaxReadThrough="0.95076" /MaxDrop="4.47937" /score="13.0972324" /energy="-9.7" /TU="NA" /idTUdmin="U2587" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2821344..2821508) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /experiment="publication(s) with functional evidences, PMID:21378193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21378193; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpxA degradation" /protein_id="YP_003097785.1" /db_xref="EnsemblGenomes-Gn:BSU33029" /db_xref="EnsemblGenomes-Tr:CAX52691" /db_xref="GOA:O32302" /db_xref="UniProtKB/Swiss-Prot:O32302" /translation="MRELDEMISRLRNRGIKVEKVKYPKQTLSEKKWVHQCKQPLKTN YRDFNGYSFT*" /label="spxO CDS" gene complement(2821344..2821508) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /label="spxO gene" promotor_-35 2821532..2821539 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2821553..2821572 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2821557..2821576) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2821563..2821675 /Source="Nicolas_S_feature" /locus_tag="new_3388000_3388112" /HighExp="dia5, Diami, T0.30H, T-0.40H, T0.0H, dia15, Salt, ferm, G135, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1271" upshifts 2821563 /Source="Nicolas_upshifts" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2821570) /Source="Nicolas_upshifts" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2821572..2821850) /Source="Nicolas_S_feature" /locus_tag="new_3388009_3388287_c" /HighExp="Etha, Gly, S2, Glucon, Pyr, G/S, S1, Lbstat, Cold, HiTm" /AntisenseName="yuxN" /AntisenseCor="-0.128326996122899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigH, SigA" /TUshortPSig="0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1272" promotor_-35 complement(2821590..2821597) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2821676..2822551 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391183.1" /db_xref="EnsemblGenomes-Gn:BSU33030" /db_xref="EnsemblGenomes-Tr:CAB15293" /db_xref="GOA:P40950" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG11072" /db_xref="UniProtKB/Swiss-Prot:P40950" /translation="MKEKEKLIIETALKLFAQKGYNSTSVQEIAKECKISKGAFYIYF PSKEALLLSMLNYYYDKTFTRILNIKTKGDSPRTAYRKQLTVLYENILEHKDFISMQL KEGSLPYTEEVEQCAKKIRQSSLQFHIDSLLNIYGKKAEPYTAELCFLIEGISQIYLE CMILLGYTVKPSQLADIIMNRIDDMVKGMSERNDKPFITLEEASSLFGPLTHGRPDPL TESIVKSLRDKINSLNTNSSLELSESLDILEAEMKKKTPKLAIIKGMIHNLTESEALA KDAEQLKYLLKQQHI*" /label="yuxN CDS" gene 2821676..2822551 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /label="yuxN gene" promotor_-10 complement(2821840..2821859) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2821850) /Source="Nicolas_upshifts" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2821852..2822393) /Source="Nicolas_S_feature" /locus_tag="new_3388289_3388830_c" /HighExp="LBGstat, Cold, S2, Glucon, S1, Pyr, G/S, C30, GM 10, GM-0.1" /AntisenseName="yuxN" /AntisenseCor="-0.341746670828522" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigH, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1273" promotor_-35 complement(2821873..2821880) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2822385..2822403) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2822393) /Source="Nicolas_upshifts" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2822395..2822524) /Source="Nicolas_S_feature" /locus_tag="new_3388832_3388961_c" /HighExp="S2, S1, G/S, Glucon, Pyr, T3.30H, M9-stat, BT, Cold, T4.0H" /AntisenseName="yuxN" /AntisenseCor="-0.30886083736579201" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1274" promotor_-35 complement(2822416..2822423) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2822526 /Source="Nicolas_upshifts" /id="D1707" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="3.14099" /MaxDrop="3.7614" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2589" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" downshifts complement(2822569) /Source="Nicolas_upshifts" /id="D1708" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="5.30537" /MaxDrop="3.29426" /score="-2.73895091" /energy="-13.6" /TU="U2593,U2594" /idTUdmin="U2591" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(2822587..2823975) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /EC_number="4.2.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:2509422, 3130545, 3923430, 9647666, 22914898, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509422, 3130545, 3923430, 9647666, 22914898, 28032445; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fumarate hydratase" /protein_id="NP_391184.1" /db_xref="EnsemblGenomes-Gn:BSU33040" /db_xref="EnsemblGenomes-Tr:CAB15294" /db_xref="GOA:P07343" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR005677" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10384" /db_xref="UniProtKB/Swiss-Prot:P07343" /translation="MEYRIERDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPMRVV KAFAILKRSTALANKRLGNLDAEKAEAIAAVCDDVLKGKYDDNFPLVVWQTGSGTQSN MNMNEVVANRATALLKEKNSDQTIHPNDDVNRSQSSNDTFPTAMHVAAVLAVYEQLVP ALDQLRNTLDEKAKAYNDIVKIGRTHLQDATPLTLGQEISGWVHMLDRSKEMILEATD KMRALAIGGTAVGTGINAHPEFGELVSEEITKLTGQTFSSSPNKFHALTSHDEITYAH GALKALAADLMKIANDVRWLASGPRCGIGEIVIPENEPGSSIMPGKVNPTQSEALTMI AAQIMGNDATIGFAASQGNFELNVFKPVIIYNFLQSVQLLSDGMNSFHDKCAVGIEPN KETIQENLSNSLMLVTALNPHIGYENAAKIAKLAHKEGLTLKEAALKLELLTEEQFNE MVKPEDMVKPKA*" /label="fumC CDS" gene complement(2822587..2823975) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /label="fumC gene" upshifts complement(2823999) /Source="Nicolas_upshifts" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2824004..2824022) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2824033..2824041) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2824042..2824227) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097786.1" /db_xref="EnsemblGenomes-Gn:BSU33049" /db_xref="EnsemblGenomes-Tr:CAX52692" /db_xref="InterPro:IPR025088" /db_xref="UniProtKB/Swiss-Prot:C0H3R3" /translation="MAQVRLAGKQEEIEQLIRSFEQHYDVSYTSKEYGRTNPKYKYSK DSRVYLELKLKSAKIEK*" /label="yvzF CDS" gene complement(2824042..2824227) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /label="yvzF gene" downshifts 2824231 /Source="Nicolas_upshifts" /id="D1709" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="1.13377" /MaxDrop="4.4478" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2595" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2824271..2824290) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2824280..2824286 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2824285) /Source="Nicolas_upshifts" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2824300..2824311 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2824303 /Source="Nicolas_upshifts" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2824306..2824309) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2824345..2825793 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the GerA germination receptor" /protein_id="NP_391185.2" /db_xref="EnsemblGenomes-Gn:BSU33050" /db_xref="EnsemblGenomes-Tr:CAB15295" /db_xref="GOA:P07868" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10385" /db_xref="UniProtKB/Swiss-Prot:P07868" /translation="MEQTEFKEYIHDNLALVLPKLKENDDLVKNKKMLANGLVFYYLY FSEMTDENKVSEAIKTLIKDEETLTLDQVKKRLDQLDARPVETAKKTIESILNGNCAV FINGLDKAYILTTGKKKTRSLTEPTTEKVVRGPKVAFVEDIDTNLALIRQRTSHPKLI TKKIMIGENKLKPAAIMYIEGKAKKSVIKEVKARLKNIQLEDIQDSGTLEELIEDNKY SPFPQIQNTERPDKVSSALFNGRVAILVDSSPFVLLVPVSLGILMQSPDDYYERWISA SLIRSLRFASIFITLFLSSIYITLVSFHQGLLPTALAVTISANRENVPFPPIFEALLM EVTIELLREAGLRLPNPLGQTIGLVGGVVIGQAAVEANLVSSILVIVVSVIALASFTV PQYGMGLSFRVLRFISMFSAAILGLYGIILFMLVVYTHLTRQTSFGSPYFSPNGFFSL KNTDDSIIRLPIKNKPKEVNNPNEPKTDSTET*" /label="gerAA CDS" gene 2824345..2825793 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /label="gerAA gene" S_feature complement(2825341..2827984) /Source="Nicolas_S_feature" /locus_tag="new_3391778_3394421_c" /HighExp="Cold, H2O2, G135, G180, Paraq, G150, Oxctl, T-5.40H, LBGstat, T-4.40H" /AntisenseName="gerAC" /AntisenseCor="-9.7163861003102397E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1275" CDS 2825762..2826859 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16740944, 16850406, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16740944, 16850406, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA; putative transporter" /protein_id="NP_391186.1" /db_xref="EnsemblGenomes-Gn:BSU33060" /db_xref="EnsemblGenomes-Tr:CAB15296" /db_xref="GOA:P07869" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10386" /db_xref="UniProtKB/Swiss-Prot:P07869" /translation="MSQKQTPLKLNTFQGISIVANTMLGAGLLTLPRALTTKANTPDG WITLILEGFIFIFFIYLNTLIQKKHQYPSLFEYLKEGLGKWIGSIIGLLICGYFLGVA SFETRAMAEMVKFFLLERTPIQVIILTFICCGIYLMVGGLSDVSRLFPFYLTVTIIIL LIVFGISFKIFDINNLRPVLGEGLGPIANSLTVVSISFLGMEVMLFLPEHMKKKKYTF RYASLGFLIPIILYILTYIIVVGALTAPEVKTLIWPTISLFQSFELKGIFIERFESFL LVVWIIQFFTTFVIYGYFAANGLKKTFGLSTKTSMVIIGITVFYFSLWPDDANQVMMY SDYLGYIFVSLFLLPFILFFIVALKRRITTK*" /label="gerAB CDS" gene 2825762..2826859 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /label="gerAB gene" CDS 2826856..2827977 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA" /protein_id="NP_391187.1" /db_xref="EnsemblGenomes-Gn:BSU33070" /db_xref="EnsemblGenomes-Tr:CAB15297" /db_xref="GOA:P07870" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG10387" /db_xref="UniProtKB/Swiss-Prot:P07870" /translation="MKIRILCMFICTLLLSGCWDSENIEELSLVIGIGLDKPDDENLE LTQQILVPKIISAKEGSSSDPTQLSITKGKTVHQMMRTSALKHKPTFSQHLRLILLSK SVIADQIGMDAIINQFVRDNGTRRSSYVFITNGRTKDIFNMNDEGEPASNVIYDLTEN NKVTIRTMEPVTLGEISEHLTSDDSFLIPHVGKENGKLAINGASIIKNKLWHRDLTPI EVQNISLFSGTVEGGVIDLKRDGHLFSYEVYSSNRKIKTAYKDGKFKFTVTRNIEGRL SEDWNPNEDSFKDSYIKSIEKTVEKRVHETVTSFITEKLQKEIKADVTGLGNEVRIHY PQKWKKISRKWDDDYFSNAEIDYRVNVIVRDFGTKGANK*" /label="gerAC CDS" gene 2826856..2827977 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /label="gerAC gene" CDS complement(2827985..2828620) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvqE] responding to cell wall stress" /protein_id="NP_391188.1" /db_xref="EnsemblGenomes-Gn:BSU33080" /db_xref="EnsemblGenomes-Tr:CAB15298" /db_xref="GOA:O32197" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14133" /db_xref="UniProtKB/Swiss-Prot:O32197" /translation="MIRVLLIDDHEMVRMGLAAFLEAQPDIEVIGEASDGSEGVRLAV ELSPDVILMDLVMEGMDGIEATKQICRELSDPKIIVLTSFIDDDKVYPVIEAGALSYL LKTSKAAEIADAIRAASKGEPKLESKVAGKVLSRLRHSGENALPHESLTKRELEILCL IAEGKTNKEIGEELFITIKTVKTHITNILSKLDVSDRTQAAVYAHRNHLVN*" /label="liaR CDS" gene complement(2827985..2828620) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /label="liaR gene" CDS complement(2828598..2829680) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /function="16.12: Sense" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LiaR(YvqC)] sensing cell wall stress" /protein_id="NP_391189.1" /db_xref="EnsemblGenomes-Gn:BSU33090" /db_xref="EnsemblGenomes-Tr:CAB15299" /db_xref="GOA:O32198" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR017202" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14134" /db_xref="UniProtKB/Swiss-Prot:O32198" /translation="MRKKMLASLQWRAIRMTTGISLLLFVCLISFMMFYYRLDPLVLL SSSWFGIPFILILLLISVTVGFASGYMYGNRLKTRIDTLIESILTFENGNFAYRIPPL GDDEIGLAADQLNEMAKRVELQVASLQKLSNERAEWQAQMKKSVISEERQRLARDLHD AVSQQLFAISMMTSAVLEHVKDADDKTVKRIRMVEHMAGEAQNEMRALLLHLRPVTLE GKGLKEGLTELLDEFRKKQPIDIEWDIQDTAISKGVEDHLFRIVQEALSNVFRHSKAS KVTVILGIKNSQLRLKVIDNGKGFKMDQVKASSYGLNSMKERASEIGGVAEVISVEGK GTQIEVKVPIFPEEKGENERDSSIID*" /label="liaS CDS" gene complement(2828598..2829680) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /label="liaS gene" CDS complement(2829677..2830402) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane component associated to the LiaRS two-component system" /protein_id="NP_391190.1" /db_xref="EnsemblGenomes-Gn:BSU33100" /db_xref="EnsemblGenomes-Tr:CAB15300" /db_xref="GOA:O32199" /db_xref="InterPro:IPR016975" /db_xref="InterPro:IPR024425" /db_xref="SubtiList:BG14135" /db_xref="UniProtKB/Swiss-Prot:O32199" /translation="MTKKQLLGLIIALFGISMFLQIIGIGDLLFWPLFFLIAGYFLKK YSRDWLGSVMYIFAAFLFLKNLFSITFNLFGYAFAAFLIYAGYRLIKGKPIFEPNEKQ VNLNKKEHHEPPKDVKHPDMRSFFIGELQMMKQPFDLNDLNVSGFIGDIKIDLSKAMI PEGESTIVISGVIGNVDIYVPSDLEVAVSSAVFIGDINLIGSKKSGLSTKVYAASTDF SESKRRVKVSVSLFIGDVDVKYV*" /label="liaF CDS" gene complement(2829677..2830402) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /label="liaF gene" CDS complement(2830436..2831308) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="sensor of antibiotic stress on the cell wall" /protein_id="NP_391191.2" /db_xref="EnsemblGenomes-Gn:BSU33110" /db_xref="EnsemblGenomes-Tr:CAB15301" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14136" /db_xref="UniProtKB/Swiss-Prot:O32200" /translation="MKKMLGKLLITAGILVFFAVVVKDVFAAGLGFINGTEADSASAS PRDIDSMVIESDSKDVRIIAEERSDISAGISGDSGKLFVTENKRKLELTVKEKEFQFL NGFNRSTLIVRLPYDYKGDLAVRTSSGDVSVAGNDHLALSGLNAVSASGNTSVTDVRI QDLKVKASSGDVSISNTVSKTAGIDLASGDANLVHVSGSLDVKMTSGDFNAVLKKVTG PVSVTLTSGDANVSLPQNGSFAVNALSASGDVSSPYSFADKGHKEQHHITGTQGSGRH PIDIKTDSGDLAIR*" /label="liaG CDS" gene complement(2830436..2831308) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /label="liaG gene" promotor_-10 complement(2831327..2831346) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2831347) /Source="Nicolas_upshifts" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2831361..2831364) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2831409..2832086) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23874669, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23874669, 24666271, 28546427; Product type f: factor" /codon_start=1 /transl_table=11 /product="modulator of liaIHGFSR (yvqIHGFEC) operon expression" /protein_id="NP_391192.1" /db_xref="EnsemblGenomes-Gn:BSU33120" /db_xref="EnsemblGenomes-Tr:CAB15302" /db_xref="GOA:O32201" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG14137" /db_xref="UniProtKB/Swiss-Prot:O32201" /translation="MVLKRIRDMFVASVHEGLDKMENPKVMLNQYVRDMESDIAKAKQ TIVKQHTIAYQFKKKYEEAAEVAGKRKNQAQLAFDAGEEELAKKALTEMKYLEGKAAE HKASYEQANSQLADLKEQLAALETKLQDVKDKKQALIARANAAKAKEHMNTTFDKIDS ESAYREFLRIENRIEEMEIRANYSKSAEAGTELTRKEFADDVEAEIEKMRTLSLQKSD QTKAANE*" /label="liaH CDS" gene complement(2831409..2832086) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /label="liaH gene" downshifts complement(2831425) /Source="Nicolas_upshifts" /id="D1710" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="3.84852" /MaxDrop="3.1352" /score="-8.3477012" /energy="-4.5" /TU="U2597" /idTUdmin="U2598" /TUdmin=1243 /isTUend="FALSE" /label="downshifts" CDS complement(2832113..2832493) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427; Product type s: structure" /codon_start=1 /transl_table=11 /product="membrane anchor for the phage-shock protein A homolog LiaH" /protein_id="NP_391193.1" /db_xref="EnsemblGenomes-Gn:BSU33130" /db_xref="EnsemblGenomes-Tr:CAB15303" /db_xref="GOA:O32202" /db_xref="SubtiList:BG14138" /db_xref="UniProtKB/Swiss-Prot:O32202" /translation="MKINKKTIGGFLLIVFGISVFFGGGSFGFIIPLAIGSLMTYAGI KRFAAGKTITGIIVGGIGAIMLICSLPFVVGIALAAAMVYYGWKLMKNGSADNGVSSF DPEPASAAYQSHFDDEWEEFLKKK*" /label="liaI CDS" gene complement(2832113..2832493) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /label="liaI gene" promotor_-10 complement(2832516..2832535) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2832536) /Source="Nicolas_upshifts" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2832550..2832553) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2832655..2833923) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15273097, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux protein" /protein_id="NP_391194.1" /db_xref="EnsemblGenomes-Gn:BSU33140" /db_xref="EnsemblGenomes-Tr:CAB15304" /db_xref="GOA:O32203" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14139" /db_xref="UniProtKB/Swiss-Prot:O32203" /translation="MVNLIESDSIWKRNFNYLFFSRIVKISGDMFAFNSILWFLIYDG KGAIGTALLIAVTFLPEAVLAPVTGPFMKQTTLKFWMYFSDLTRAAIVLIIPLCHFAG FSPLWFVMTLMIVHSATGAAYNPASIALIPQIVNEQGIQKANAVLQSSAQIVRLGAVT LCGAFLTFISPSYTMLIALVLYLVSGFLVLFIKYTAVESQSESAVVTQRGTYIGRLKR GFRLVRKHQILYPLAIYCIFMNFAAAPWEALSAVYVAEDLNGQPIVYSLLKATTAAGA FLLGFVLAKVKVNRYGLLFVTAGIIEGFAFFITGMNTFLPLVFFAAFTFGAAVSAVNV PEYTIIQTSVDSEDQPQVYAVIHMISNISIPAGAVICGYAANAFGSGKVIAVGGIVEI IAGIGILLFTKLAKAERSDLIKEREASVHL*" /label="yvqJ CDS" gene complement(2832655..2833923) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /label="yvqJ gene" downshifts complement(2832668) /Source="Nicolas_upshifts" /id="D1711" /incds=0 /nref=78 /ntot=164 /MaxReadThrough="0.70612" /MaxDrop="4.80625" /score="32.7496145" /energy="-12.9" /TU="NA" /idTUdmin="U2598" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2833957..2833976) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2833968) /Source="Nicolas_upshifts" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2833991..2833998) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2834094) /Source="Nicolas_upshifts" /id="D1712" /incds=0 /nref=33 /ntot=211 /MaxReadThrough="1.54601" /MaxDrop="4.92923" /score="51.1311697" /energy="-17.1" /TU="NA" /idTUdmin="U2599" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2834100..2834681) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /EC_number="2.5.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12869542, 14704351, 17588214, 19933577, 21514283; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP:cob(I)alamin adenosyltransferase" /protein_id="NP_391195.2" /db_xref="EnsemblGenomes-Gn:BSU33150" /db_xref="EnsemblGenomes-Tr:CAB15305" /db_xref="GOA:O34899" /db_xref="InterPro:IPR016030" /db_xref="InterPro:IPR029499" /db_xref="InterPro:IPR036451" /db_xref="PDB:1RTY" /db_xref="SubtiList:BG14140" /db_xref="UniProtKB/Swiss-Prot:O34899" /translation="MKLYTKTGDKGQTGLVGGRTDKDSLRVESYGTIDELNSFIGLAL AELSGQPGFEDLTAELLTIQHELFDCGGDLAIVTERKDYKLTEESVSFLETRIDAYTA EAPELKKFILPGGSKCASLLHIARTITRRAERRVVALMKSEEIHETVLRYLNRLSDYF FAAARVVNARSGIGDVEYERSAIVFRDRNSSES*" /label="yvqK CDS" gene complement(2834100..2834681) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /label="yvqK gene" CDS complement(2834704..2836032) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 transport system, ATPase component" /protein_id="NP_391196.1" /db_xref="EnsemblGenomes-Gn:BSU33160" /db_xref="EnsemblGenomes-Tr:CAB15306" /db_xref="GOA:O34631" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14141" /db_xref="UniProtKB/Swiss-Prot:O34631" /translation="MKAEGLSGGYGDSRLINNVSLTVEKGEFLGILGPNGSGKTTLLH LLTGTLPAKKGRVYLAGKLLADYKPKELAQIMAVLPQKMDQAFTFTVEETVAFGRYPF QTGLFRQQTEKGEAIVQEAMEQTGVADFAQKPIRELSGGEQQRVYLAQALAQQPRILF LDEPTNFLDLAYQKDLLDLIKRLTRESGLAAVSVFHDLNTASLYCDGLMFMKNGTAGP KQKPEYAVTEQSIKAVYDTDVTALVHQSSPKPMIVIQPEKDSVKRQSIPFEALLQAGR DDILLQTEIPLRTLSSTPIGAGFSWSRTLIHKRLPDQPDPIEGLTACLSESGFQLQET CAMASSERLDRFVYRTYEDGELSVFICVQTGFSIWILINGYAADQFFIKALMAAEAER TKVLGDGGGTGDILIAATQTQQSENIEQRLNQLIKKGTAECIKEAAELFE*" /label="yvrA CDS" gene complement(2834704..2836032) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /label="yvrA gene" CDS complement(2836032..2837093) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 15849754, 16850406, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 permease" /protein_id="NP_391197.1" /db_xref="EnsemblGenomes-Gn:BSU33170" /db_xref="EnsemblGenomes-Tr:CAB15307" /db_xref="GOA:O34451" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG14142" /db_xref="UniProtKB/Swiss-Prot:O34451" /translation="MRKAFTRIRLRNNRYAAYIIGFSFLAVSIILGISCGSLHIPIPA VFRVFWHQGFGGSIGSDDPMYTNIMMNIRLPRVVLAALVGAALSIAGAAFQGLLKNPL ADPYTLGVSSGASVGAVVTLFLGLHLPVIGGFTLPVLSVAAALATMAAVLFFSRLVHA SMSVSTLILTGVITNSFLGAFISLIIALTGDNLLPIVHWLLGSVSMRGWSYVILFLPF FLLGTILLIINGRELNVMTYGEDKAKLLGVSVQQRKMMILIAGSLLTGSAVAVSGTIG FVGLVIPHITRLLWGTDHRHLLPLSALLGAGFLVLADLLSRTIIEPIELPIGIITSLA GAPVFALILIRQHRGGRSL*" /label="yvrB CDS" gene complement(2836032..2837093) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /label="yvrB gene" CDS complement(2837056..2838000) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative lipoprotein binding vitamin B12" /protein_id="NP_391198.1" /db_xref="EnsemblGenomes-Gn:BSU33180" /db_xref="EnsemblGenomes-Tr:CAB15308" /db_xref="GOA:O34805" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG14143" /db_xref="UniProtKB/Swiss-Prot:O34805" /translation="MKKRAGIWAALLLAAVMLAGCGNPADQKDSKAKQKTEVFPVTID DASNQDVTIKKEPKKIVSLMPSNTEITYALGLGDKVVGVTTNDTYPKEVKKVEKVGDM NVNVEKVISLKPDLVLAHESSMSASADAIKQLKDAGITVLTVNDAQSFSEVYKSIEMI GEAGGAEKKADQLVKSMKSDLKDIQEKAKTISKDEEKSVFIEVSPDPDIYTTGKDTFM NEMLNVIHAKNAAADQTGWVQMTDEAIVKLNPDAIVTTDGVKAKAVEKRDGWSEINAV KHHRVYDVDPDLVTRSGPRLIEGVEELAESIYPDTFKE*" /label="yvrC CDS" gene complement(2837056..2838000) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /label="yvrC gene" S_feature complement(2838001..2838270) /Source="Nicolas_S_feature" /locus_tag="new_3404438_3404707_c" /HighExp="LBGtran, LBGexp, Etha, LPh, S3, Lbexp, G180, dia0, HPh, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.956, 1" /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1276" misc_RNA complement(2838109..2838239) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /product="putative coenzyme B12 (AdoCbl) riboswitch" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 17038623, 21140903, 25917914; Product type n: RNA" /function="16.3: Control" /label="srbL RNA" gene complement(2838109..2838239) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /label="srbL gene" promotor_-10 complement(2838247..2838266) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2838270) /Source="Nicolas_upshifts" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2838272..2839199) /Source="Nicolas_S_feature" /locus_tag="new_3404709_3405636_c" /HighExp="Etha, B60, Sw, M9-stat, B36, C30, C90, Salt, G135, Gly" /AntisenseName="yvrD" /AntisenseCor="1.5286196477289399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1277" promotor_-35 complement(2838282..2838289) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2838332..2838339 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2838354..2838373 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2838358 /Source="Nicolas_upshifts" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="upshifts" CDS 2838398..2839189 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9922248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391199.1" /db_xref="EnsemblGenomes-Gn:BSU33190" /db_xref="EnsemblGenomes-Tr:CAB15309" /db_xref="GOA:O34782" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14144" /db_xref="UniProtKB/Swiss-Prot:O34782" /translation="MDLQLKEKLVLITGSTSGIGKAAAKSFLQEGAAVIVNGRKQETV DRTIEELSGYGTVHGAAADLSKTDEAAAFIEKVNEIGDIDILVNNLGFFEVKDFADVT DEEWNQYFEVNVMSAVRTSRHFLPKMLAKNSGRILNIASEAGVKPLPTMIPYSMTKTA LISLSRGMAEMTKGTNVTVNSVLPGPTWTEGVASYMEGAAQAAGQDTDTFIKDYFKVN EPTSLIQRYATAEEVANTIVFLASDAASAINGTAQRVEGGIIRSL*" /label="yvrD CDS" gene 2838398..2839189 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /label="yvrD gene" downshifts 2839060 /Source="Nicolas_upshifts" /id="D1713" /incds=1 /nref=2 /ntot=89 /MaxReadThrough="6.202" /MaxDrop="3.35017" /score="36.8938178" /energy="-12" /TU="U2600" /idTUdmin="U2600" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 2839170 /Source="Nicolas_upshifts" /id="D1714" /incds=0 /nref=105 /ntot=218 /MaxReadThrough="2.44739" /MaxDrop="6.33457" /score="36.8938178" /energy="-12" /TU="NA" /idTUdmin="U2600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2839227..2840105) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar lactone lactonase" /protein_id="NP_391200.1" /db_xref="EnsemblGenomes-Gn:BSU33200" /db_xref="EnsemblGenomes-Tr:CAB15310" /db_xref="GOA:O34940" /db_xref="InterPro:IPR005511" /db_xref="InterPro:IPR011042" /db_xref="InterPro:IPR013658" /db_xref="SubtiList:BG14145" /db_xref="UniProtKB/Swiss-Prot:O34940" /translation="MDAVLEADTRAVIGEGPLWDEENGRLYWVDILGSELHIFDPEEK INRSIKFKSFVTALAKYSKDELIMTMKDGFYLYHLRDDSLEKIKQPKDMHESLRFNDA KCDPYGRLWAGTTSMEGEQKQASLYRLNLDGSLVKIKDQVSTSNGLDWDRERNLMYYI DTPTQEIVRYSYDPQSGDVSNPEPVYRFDQSDGLPDGMTIDQNGMLWVALFGGSRVVH IDPFQKKEINSISVPAKYVTCCAFGGRDLKTLYITTATEQMTEKERYEQPHAGGLFSA QLETGGYQPVPFAGDV*" /label="yvrE CDS" gene complement(2839227..2840105) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /label="yvrE gene" downshifts complement(2839244) /Source="Nicolas_upshifts" /id="D1715" /incds=0 /nref=31 /ntot=260 /MaxReadThrough="7.17016" /MaxDrop="5.74101" /score="29.8014794" /energy="-12" /TU="U2601" /idTUdmin="U2602" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2840129..2840147) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2840148) /Source="Nicolas_upshifts" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2840161..2840167) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2840177..2841919) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrH)]" /protein_id="NP_391201.2" /db_xref="EnsemblGenomes-Gn:BSU33210" /db_xref="EnsemblGenomes-Tr:CAB15311" /db_xref="GOA:O34989" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14146" /db_xref="UniProtKB/Swiss-Prot:O34989" /translation="MRLRWKFLFHFFGQMLIVILLLTVMLVASFFYLDARFSDAESNS GLTKATTDTLEAYLDVNEDGTWEVDNFLKKSVDKQHGWMQIIDSEGNTDYSYGVPKDV PGTYTKKELLSIYKTKKLHNYKLNYWAINIEDKSYLLLSGWKSKSEQLLTSVEKREQK IDSLAHYKSSTIDYIKRKKGAIYLLDSNGKILDSINSTKSERKTMNQLELLKYSSKPW NYKREISVKILNKDRWMVATVPNPVYVTDQEFNKSFLKVVLKAMFLVMAVLFMYIIWM TVWYMFRFGLPIFHTIRWLVNLSKGKLEEPRNREGRPVSKNKKGKIKQPYRFFGEIFE SMDQLTETLRRDKRNREKIQATREEWIAGLSHDLKTPLSSIYGYSMMLESKQYDWSPE EVKEMGQVVREKSEYMSKLIEDLNLTYRLKNDALPIERKLTSLIPFFKNVIEDFKKNP FSEGYDISFVSKEEHIEFALDEAWFRRILENLLGNAVKHNGKGTEIQVILEQTKNHIS LKVKDNGKGMDEETITHLFNRYYRGTNTKDSTAGTGLGLAIAKELVHLHNGTIHVNSR TNIGTVITILFKKQ*" /label="yvrG CDS" gene complement(2840177..2841919) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /label="yvrG gene" CDS complement(2841916..2842629) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrG)]" /protein_id="NP_391202.2" /db_xref="EnsemblGenomes-Gn:BSU33221" /db_xref="EnsemblGenomes-Tr:CAB15312" /db_xref="GOA:P94504" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12452" /db_xref="UniProtKB/Swiss-Prot:P94504" /translation="MENASILIVDDEKAIVDMIKRVLEKEGYRNILDAASAEEAIPVV KANKVDLIVLDVMMGGMSGFEACTLIREYSDAPIFFLTARSSDADKLSGFAVGADDYI TKPFNPLELAARIRAHLKRTYQSKETSSNQTYTYDYFTFSPQNAELIVGGEAVACSAQ LLQLLQYFCEHPNVVLSKDQIYEKVWGYPSYGDNNTVMVHIRKLREKIERDPSNPEYI VTVRGLGYRFIPNPEGKRS*" /label="yvrH CDS" gene complement(2841916..2842629) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /label="yvrH gene" misc_feature complement(2842660..2842679) /Source="Nicolas_upshift_promotors" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2842678) /Source="Nicolas_upshifts" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="upshifts" CDS complement(2842782..2843021) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sigma-O" /protein_id="YP_003097787.1" /db_xref="EnsemblGenomes-Gn:BSU33222" /db_xref="EnsemblGenomes-Tr:CAX52693" /db_xref="GOA:C0H3R4" /db_xref="UniProtKB/Swiss-Prot:C0H3R4" /translation="MDGQFEQKKKQKDETYDIEHLIACFSPMIRKKLSNTSYQEREDL EQELKIKMFEKADMLLCQDVPGFWEFILYMVDENS*" /label="rsoA CDS" gene complement(2842782..2843021) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /label="rsoA gene" downshifts complement(2842789) /Source="Nicolas_upshifts" /id="D1716" /incds=0 /nref=4 /ntot=30 /MaxReadThrough="2.45068" /MaxDrop="3.82244" /score="12.6471586" /energy="-8.2" /TU="NA" /idTUdmin="U2605" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2843017..2843035) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2843025..2843555) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16306698, 18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16306698, 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="alternative sigma factor" /protein_id="NP_391203.2" /db_xref="EnsemblGenomes-Gn:BSU33230" /db_xref="EnsemblGenomes-Tr:CAB15313" /db_xref="GOA:O34843" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14147" /db_xref="UniProtKB/Swiss-Prot:O34843" /translation="MKHPIVKHFLSNPQHYRLFKNVMESPNEKDARSLDELFKQFYKE IRIVKYMNSMIRIFSIDFDKRVRKNQKRYPLTVDHPEAGDRLSSETGSDAFEEFLDRQ DDLSQHVQDYQLYQAIQKLTDKQKSVLTKVYLHGATMQEIADSLGESRQNISNIHKKG LENIRKQLAAQKKGEK*" /label="sigO CDS" gene complement(2843025..2843555) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /label="sigO gene" upshifts complement(2843026) /Source="Nicolas_upshifts" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2843050..2843056) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2843558..2843577) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2843565) /Source="Nicolas_upshifts" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" CDS 2843570..2843908 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in oxalate decarboxylase expression" /protein_id="YP_003097788.1" /db_xref="EnsemblGenomes-Gn:BSU33239" /db_xref="EnsemblGenomes-Tr:CAX52694" /db_xref="InterPro:IPR024419" /db_xref="UniProtKB/Swiss-Prot:C0H3R5" /translation="MTVKDFDSPSNRLPTKLNEGKQKKVNYYFPPSVFQNTLQQFTFY RFSSLTYMTAEKEGRYFPMDQVFIEEVVKQIGNLGFPALIAMYLLTRFEKKFDQLIEL MTELKDHAKK*" /label="yvrJ CDS" gene 2843570..2843908 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /label="yvrJ gene" promotor_-35 complement(2843592..2843599) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2843608..2843627) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2843620) /Source="Nicolas_upshifts" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2843642..2843648) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2843654..2843754 /Source="Nicolas_upshift_promotors" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="promotor_no_box" upshifts 2843714 /Source="Nicolas_upshifts" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="upshifts" promotor_no_box 2843882..2843982 /Source="Nicolas_upshift_promotors" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2843942..2844028 /Source="Nicolas_S_feature" /locus_tag="new_3410379_3410465" /HighExp="T5.0H, T4.0H, T3.30H, Lbstat, T3.0H, nit, T2.0H, T2.30H, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.317" /TUlongSig="Sig-" /TUlongPSig="0.278" /label="S1278" upshifts 2843942 /Source="Nicolas_upshifts" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="upshifts" CDS 2844029..2845186 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase" /protein_id="NP_391204.1" /db_xref="EnsemblGenomes-Gn:BSU33240" /db_xref="EnsemblGenomes-Tr:CAB15314" /db_xref="GOA:O34714" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="PDB:1J58" /db_xref="PDB:1L3J" /db_xref="PDB:1UW8" /db_xref="PDB:2UY8" /db_xref="PDB:2UY9" /db_xref="PDB:2UYA" /db_xref="PDB:2UYB" /db_xref="PDB:2V09" /db_xref="PDB:3S0M" /db_xref="PDB:4MET" /db_xref="PDB:5HI0" /db_xref="SubtiList:BG14148" /db_xref="UniProtKB/Swiss-Prot:O34714" /translation="MKKQNDIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGT VSNMKFSFSDTHNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEW AYMIYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVFDDGSF SENSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQLPGSLKDDIVEGP NGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSKTIASALVTVEPGAMRELHWHP NTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFAMGHYVENIGDEPLVFLEI FKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVKKKCSK*" /label="oxdC CDS" gene 2844029..2845186 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /label="oxdC gene" downshifts 2845172 /Source="Nicolas_upshifts" /id="D1717" /incds=0 /nref=11 /ntot=87 /MaxReadThrough="4.83038" /MaxDrop="4.39135" /score="2.61432951" /energy="-9.4" /TU="U2607" /idTUdmin="U2607" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 2845247..2845657 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18573182, 19047353, 26651345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18573182, 19047353, 26651345; Product type f: factor" /codon_start=1 /transl_table=11 /product="acid stress-sensitive anti sigma factor" /protein_id="NP_391205.1" /db_xref="EnsemblGenomes-Gn:BSU33250" /db_xref="EnsemblGenomes-Tr:CAB15315" /db_xref="GOA:O34686" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14149" /db_xref="UniProtKB/Swiss-Prot:O34686" /translation="MKHQNPSKRLLRLSIKYLLAAAAVVLTYFAVIYILFSLAGTSYR SAAHVLLFAVVFLVLGLCFEPFERLMIHSFTFFKTGKRLFILLAGIVQLLFLWMTAHT TDQLISDIWLSTTEEMIVAAVFLILDKCNSALPS*" /label="rsiO CDS" gene 2845247..2845657 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /label="rsiO gene" downshifts 2845656 /Source="Nicolas_upshifts" /id="D1718" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.57216" /MaxDrop="3.72691" /score="-9.50136752" /energy="-7.4" /TU="NA" /idTUdmin="U2607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2845691..2846920) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391207.3" /db_xref="EnsemblGenomes-Gn:BSU33260" /db_xref="EnsemblGenomes-Tr:CAB15317" /db_xref="GOA:P46324" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG11368" /db_xref="UniProtKB/Swiss-Prot:P46324" /translation="MLEHIRISFQSIFSHKLRSILTMLGVIIGIAAIIAIVSMLKGQS EQLKQSMIGMGNNAINVVYQPSGGEEESGGPQVSYASAPPVAEETVKAIKSDPMVKGL SLYYLSEGASVFHLTNVSYPQVYGVDDDYFDMFPIRITEGRKLTENDLNSTHQVVMIN EAVRDELFPDGEALHKSIEMNGVPFKVVGVFKEKNQQESMFEGDYANPVLYVPKKVWP LIEGFDAPTQIAVQADSSEHIQEAGVMAADLLNQGLSEAELEKAEYSVMDLQEIAQEV ESFNQSFALLLGGIASISLLVGGIGVMNIMLVSVTERTREIGIKKALGAKRRVILFQF LTEAVVLTSIGGILGVLAGFGIAKLLTVIFPMPFIVSIPAVVGALIFSMAVGIIFGLL PSIKASKLQPVDALRYE*" /label="yvrN CDS" gene complement(2845691..2846920) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /label="yvrN gene" downshifts complement(2845708) /Source="Nicolas_upshifts" /id="D1719" /incds=0 /nref=10 /ntot=218 /MaxReadThrough="2.36812" /MaxDrop="4.29282" /score="13.74435" /energy="-11.3" /TU="NA" /idTUdmin="U2608" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2846913..2847602) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544226, 22517742; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391208.2" /db_xref="EnsemblGenomes-Gn:BSU33270" /db_xref="EnsemblGenomes-Tr:CAB15318" /db_xref="GOA:O34979" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14151" /db_xref="UniProtKB/Swiss-Prot:O34979" /translation="MLTLNNISKSYKLGKEEVPILKHINLTVQAGEFLAIMGPSGSGK STLMNIIGCLDRPTSGTYTLDQIDILKGKDGALAEIRNESIGFVFQTFHLLPRLTALQ NVELPMIYNKVKKKERRQRAYEALEKVGLKDRVSYKPPKLSGGQKQRVAIARALVNQP RFILADEPTGALDTKSSEQILALFSELHREGKTIIMITHDPDVAKKADRTVFIRDGEL VLDERGDISHA*" /label="yvrO CDS" gene complement(2846913..2847602) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /label="yvrO gene" CDS complement(2847586..2848779) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter membrane fusion component" /protein_id="NP_391209.1" /db_xref="EnsemblGenomes-Gn:BSU33280" /db_xref="EnsemblGenomes-Tr:CAB15319" /db_xref="GOA:O35007" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG14152" /db_xref="UniProtKB/Swiss-Prot:O35007" /translation="MSKKKKWLIGGAICAGVLVLAGIGAGGFYFFTHMNQVAVSSEPY AESVAVYMGGDSESGQTFSGKVEPEKQQKVYIDSEKGSIKKTYVKEGDQVKKGDKLFE YEGEDHSDEVEQANLQIEMTNLQINRLQKSITETEKKLKVAGKEEKNQLQDELDQTNF DLKTSQLELKQHQKELAGLTKNKGSNVITSKHDGIVQSVNQDIADGATGDQAAGPYIQ IVSTGKYLVKSQINELLMDTIKKGSKVRVTLKTGGEGEWKGKVTSIGKLPAGAGEGEE SESFADEEMNPQSSNYPFTILLDSHKGLEVGYHVNIEVMSDNADADTIKLPSDMVIQD DGEPYVWKADENHKAVKQPVEIGETDENDMVEIKSGLTPEDYVIYPDPAVKEGKQVTV NADTE*" /label="yvrP CDS" gene complement(2847586..2848779) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /label="yvrP gene" promotor_-10 complement(2848823..2848842) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2848836) /Source="Nicolas_upshifts" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2848857..2848864) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2848950..2849759) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ATP-binding protein)" /protein_id="NP_391210.1" /db_xref="EnsemblGenomes-Gn:BSU33290" /db_xref="EnsemblGenomes-Tr:CAB15335" /db_xref="GOA:P49938" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11390" /db_xref="UniProtKB/Swiss-Prot:P49938" /translation="MNSLSTEQLGIGYGDRVIVEDLNISIPKGKITTLIGPNGCGKST ILKTMSRIMRSHAGAVYLNGKAIHKMSTKDIAKDMAILPQTPEAPSGLTVHELVSYGR FPHQSGFGRLNDEDRRIIKWALEETGMAEYAERPIEALSGGQRQRVWIAMALAQGTEL LLLDEPTTYLDLAHQLEILQLLDRLNKEQGRTILMVIHDLNHAARFSHYMIALKKGTV IKEGTALEVMTPDILKQVFQIDAEIVTDPRTNKPVCLTYDLIKNEKELVTV*" /label="fhuC CDS" gene complement(2848950..2849759) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /label="fhuC gene" downshifts complement(2848967) /Source="Nicolas_upshifts" /id="D1720" /incds=0 /nref=190 /ntot=245 /MaxReadThrough="1.31294" /MaxDrop="6.48454" /score="40.5986253" /energy="-11" /TU="NA" /idTUdmin="U2610" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2849106..2849115 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2849128..2849147 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2849132 /Source="Nicolas_upshifts" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2849775..2850785) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251, 15849754, 16850406, 24362930; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391211.1" /db_xref="EnsemblGenomes-Gn:BSU33300" /db_xref="EnsemblGenomes-Tr:CAB15336" /db_xref="GOA:P49937" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11391" /db_xref="UniProtKB/Swiss-Prot:P49937" /translation="MKTKTNKPLIVMAVTFLLIVVVFFISLNLGVIKIAPLKTLQVFF GQGTARDELVLFEFRLPRIILSLLVGAGISVAGAILQSVSQNELAEPGILGINAGGSL AVVLFIYFFQGSASDLSFFGTFMLPFSALAGAILAAFLIYILAWKKGVTPIRLILVGI GVNAGFNALLLIFQLKMDPHDFMQAAVWISGSIWGANWNMIWAILPWIVILLLFTLYK ARYLNIMQLGDQLATGLGTAVEKERRILLLAAVTLAASCVAAAGGIAFLGLIAPHVAR RLTGPRHQTLIPVSAFIGSFLFLLADTLARNVLAPSEIPVGLVISVLGAPYFIYLLMK AN*" /label="fhuG CDS" gene complement(2849775..2850785) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /label="fhuG gene" CDS complement(2850785..2851939) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 15849754, 16850406, 24362930; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391212.1" /db_xref="EnsemblGenomes-Gn:BSU33310" /db_xref="EnsemblGenomes-Tr:CAB15337" /db_xref="GOA:P49936" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11389" /db_xref="UniProtKB/Swiss-Prot:P49936" /translation="MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIR TASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISLGAADIHLRTVWEAIFHYQPTKT SHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAF AFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGIST AIAIRFDVAQDISFWYAGGVAGVKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDL AKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHITRFLVGVDYRWIIPC SAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL*" /label="fhuB CDS" gene complement(2850785..2851939) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /label="fhuB gene" promotor_-10 complement(2851872..2851891) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2851889) /Source="Nicolas_upshifts" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2851903..2851910) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2851951..2851958 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2851973..2851992 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2851982 /Source="Nicolas_upshifts" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2852037..2852984 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 26919525; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ferrichrome-bindinglipoprotein)" /protein_id="NP_391213.1" /db_xref="EnsemblGenomes-Gn:BSU33320" /db_xref="EnsemblGenomes-Tr:CAB15338" /db_xref="GOA:P37580" /db_xref="InterPro:IPR002491" /db_xref="PDB:3G9Q" /db_xref="PDB:3HXP" /db_xref="SubtiList:BG10828" /db_xref="UniProtKB/Swiss-Prot:P37580" /translation="MTHIYKKLGAAFFALLLIAALAACGNNSESKGSASDSKGAETFT YKAENGNVKIPKHPKRVVVMADGYYGYFKTLGINVVGAPENVFKNPYYKGKTNGVENI GDGTSVEKVIDLNPDLIIVWTTQGADIKKLEKIAPTVAVKYDKLDNIEQLKEFAKMTG TEDKAEKWLAKWDKKVAAAKTKIKKAVGDKTISIMQTNGKDIYVFGKDFGRGGSIIYK DLGLQATKLTKEKAIDQGPGYTSISLEKLPDFAGDYIFAGPWQSGGDDGGVFESSIWK NLNAVKNGHVYKMDPIGFYFTDPISLEGQLEFITESLTK*" /label="fhuD CDS" gene 2852037..2852984 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /label="fhuD gene" downshifts 2852960 /Source="Nicolas_upshifts" /id="D1721" /incds=0 /nref=168 /ntot=245 /MaxReadThrough="3.82329" /MaxDrop="5.73183" /score="11.0136807" /energy="-12.1" /TU="U2611" /idTUdmin="U2611" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 2853004 /Source="Nicolas_upshifts" /id="D1722" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="3.01143" /MaxDrop="4.08479" /score="11.0136807" /energy="-12.1" /TU="NA" /idTUdmin="U2611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 2853158 /Source="Nicolas_upshifts" /id="D1723" /incds=0 /nref=8 /ntot=87 /MaxReadThrough="0.219110000000001" /MaxDrop="3.67928" /score="7.53231618" /energy="-13.7" /TU="NA" /idTUdmin="U2611" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(2853219..2854628) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14627808, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lysine permease" /protein_id="NP_391214.1" /db_xref="EnsemblGenomes-Gn:BSU33330" /db_xref="EnsemblGenomes-Tr:CAB15339" /db_xref="GOA:O32204" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG14154" /db_xref="UniProtKB/Swiss-Prot:O32204" /translation="MEQTKKWGFWLLTAFVVGNMVGSGIFSLPSSLASIASPFGATSA WLLTGAGVLMIALVFGHLSIRKPELTAGPQSYARALFSDPKKGNAAGFTMVWGYWVAS WISNVAIITSLAGYLTSFFPILVDKREMFSIGGQEVTLGQLLTFAVCTILLWGTHAIL VASINGASKLNFVTTLSKVLGFVFFIVAGLFVFQTSLFGHFYFPVQGENGTSIGIGGQ VHNAAISTLWAFVGIESAVILSGRARSQRDVKRATITGLLIALSIYIIVTLITMGVLP HDKLVGSEKPFVDVLYAIVGNAGSVIMALLAILCLFGTMLGWILLGSEVPYQAAKAGD FPAFFAKTNKKGSPVIALIITNVMSQVFIFSVISRTISDAFTFLTTAATLAYLIPYLV SAIYSLKVVIKGETYDQLKGSRVRDGLIAILACAYSVFVIVTGTADLTTFILGIGLFF VGLIVYPFVSNKFQKEKQA*" /label="lysP CDS" gene complement(2853219..2854628) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /label="lysP gene" downshifts complement(2853234) /Source="Nicolas_upshifts" /id="D1724" /incds=0 /nref=168 /ntot=213 /MaxReadThrough="0.441040000000001" /MaxDrop="6.03347" /score="23.064706" /energy="-13.7" /TU="NA" /idTUdmin="U2613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2854046..2854050 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2854068..2854084 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2854075 /Source="Nicolas_upshifts" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="upshifts" S_feature 2854082..2855049 /Source="Nicolas_S_feature" /locus_tag="new_3420519_3421486" /HighExp="S3, S4, S7, S5, S8, S6, Etha, M9-stat, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="7.6401427420847101E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.4" /TUlongSig="NA" /TUlongPSig="NA" /label="S1279" downshifts complement(2854730) /Source="Nicolas_upshifts" /id="D1725" /incds=0 /nref=1 /ntot=43 /MaxReadThrough="5.98281" /MaxDrop="3.61093" /score="-2.14086757" /energy="-5" /TU="U2613,U2614" /idTUdmin="U2614" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" misc_RNA complement(2854732..2854911) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22416067; Product type n: RNA" /label="kswB RNA" gene complement(2854732..2854911) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /label="kswB gene" promotor_-10 complement(2854941..2854958) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2854952) /Source="Nicolas_upshifts" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2854973..2854980) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2855006 /Source="Nicolas_upshifts" /id="D1726" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.6441" /MaxDrop="3.53891" /score="-0.527038766" /energy="-4.8" /TU="U2612" /idTUdmin="U2612" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(2855028..2855168) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054593.1" /db_xref="EnsemblGenomes-Gn:BSU33340" /db_xref="EnsemblGenomes-Tr:CAE01467" /db_xref="GOA:Q7WY58" /db_xref="InterPro:IPR014220" /db_xref="SubtiList:BG14174" /db_xref="UniProtKB/Swiss-Prot:Q7WY58" /translation="MGFFNKDKGKRSEKEKNVIQGALEDAGSALKDDPLQEAVQKKKN NR*" /label="sspJ CDS" gene complement(2855028..2855168) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /label="sspJ gene" downshifts complement(2855038) /Source="Nicolas_upshifts" /id="D1727" /incds=0 /nref=40 /ntot=87 /MaxReadThrough="4.06523" /MaxDrop="5.5784" /score="-1.94521013" /energy="-14.5" /TU="U2614" /idTUdmin="U2614" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" upshifts complement(2855196) /Source="Nicolas_upshifts" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="upshifts" S_feature complement(2855198..2855786) /Source="Nicolas_S_feature" /locus_tag="new_3421635_3422223_c" /HighExp="S6, S8, S7, S5, BT, G135, Diami, G180, LBGstat, S4" /AntisenseName="yvsG" /AntisenseCor="0.46604658967097301" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1280" promotor_-10 complement(2855201..2855212) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-10" promotor_-35 complement(2855226..2855232) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-35" promotor_-35 2855258..2855265 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2855279 /Source="Nicolas_upshifts" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2855281..2855300 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2855335..2855817 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_391215.1" /db_xref="EnsemblGenomes-Gn:BSU33350" /db_xref="EnsemblGenomes-Tr:CAB15340" /db_xref="GOA:O32205" /db_xref="InterPro:IPR007404" /db_xref="InterPro:IPR016956" /db_xref="SubtiList:BG14153" /db_xref="UniProtKB/Swiss-Prot:O32205" /translation="MTGKTHIMGGIASCTAAAYYYGFDPVLMAASGAVGALIPDICHT QSKIGRKFPILSKVVSSVFGHRTFTHSLLFMLIMFFITSTYIPDKNISAGLMIGMASH LILDAWTVNGIKLLFPSTIRVRLPLYMKTGSFSEQLVLAGLTLASCYYFYMLFHGRMF *" /label="yvsG CDS" gene 2855335..2855817 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /label="yvsG gene" promotor_-35 2855831..2855838 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2855852..2855871 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2855864 /Source="Nicolas_upshifts" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2855917..2857770 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="primase of polyglycerolphosphate lipoteichoic acid (LTA) synthesis" /protein_id="NP_391216.1" /db_xref="EnsemblGenomes-Gn:BSU33360" /db_xref="EnsemblGenomes-Tr:CAB15341" /db_xref="GOA:O32206" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG14092" /db_xref="UniProtKB/Swiss-Prot:O32206" /translation="MKGTFFHNQRFLCFSILFMWIKTYVIYKLGFDLQIDTLLEELML LVNPLSFILPLFGIGLFLKENKQRAFLLIANLVLTVILISNTIFYGFYIDFITIPVLF QASNMSDMGSSVKELFHPLFIALFVDLVFLLLFARKTKHPQTKAAPHTIKRYYAASCG MLLCTLALAEVQQPKLLAHSFDREMLVKSIGLFQFHIYDTISQTVNISAKAFADEDSI TAIKNYTEADYSKPDQSKFGLAKGRNVIFVTLESTQSFVLNEKVNGKEITPFMNDLIK KSYSFDHFYQQTEQGKTSDSEFIVANSLYPSLSGAVFFTKSDHQFHTMYKSLKQHDYY SAVFHANHKTFWNRDVMYDTFGIDRFFDVDDFHVTPGTSTSWGLKDKEFLEQSAKKLK SLPQPFYSSFITLTNHFPFEIDEKDQLIDEFDSSSDLLNRYVTTVRYEDEALKHFIKK LKDEGLYENSMIVFMGDHYGISEAHNEAMAEFLGKDEITPYDNVQLQRVPFIIHIPGI TDQQPETIPDAGGQVDVRPTLMHLLGVETKGDIQFGNDLLSGDRTPFAVLRNGSFITN DYVYTKNTCYSQKTGEVLEDQDACLPYKEKANEELSLSDKILNGDLLRFSE*" /label="ltaSP CDS" gene 2855917..2857770 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /label="ltaSP gene" downshifts 2857756 /Source="Nicolas_upshifts" /id="D1728" /incds=0 /nref=30 /ntot=171 /MaxReadThrough="1.18268" /MaxDrop="3.6959" /score="21.1397957" /energy="-10.5" /TU="NA" /idTUdmin="U2615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2857798..2858724) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative molybdate binding regulator" /protein_id="NP_391217.1" /db_xref="EnsemblGenomes-Gn:BSU33370" /db_xref="EnsemblGenomes-Tr:CAB15342" /db_xref="GOA:O32207" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010093" /db_xref="InterPro:IPR024370" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14093" /db_xref="UniProtKB/Swiss-Prot:O32207" /translation="MNETSSYTIEEVAGLLKVSKLTVYDLIKKGVLPAYRVGRQMRVD EEDLKQYKTNMRMSQPIAAKEAPKQVQEAEPDGRPNVMISGQDISMDILSKHLENAIQ ETPLRKYKGSLNSLIDMYQGKCDIVSLHLYDAETGQYNAPYVKRILTGEPFCLINVVL RKAGLYVQKGNPKNIQGWKDLKRADIRIINREKGSGARVLLDEQLGLLGVNPADVVGY GDIVTDHYAAASQVSSGQADAGIGAQHAAHMGSVDFIPLIDEQYDIVVLKKNEQLLKA VKEILNSEDYKANLSHLNGYETKLTGKVILET*" /label="yvgK CDS" gene complement(2857798..2858724) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /label="yvgK gene" downshifts complement(2857810) /Source="Nicolas_upshifts" /id="D1729" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="0.15268" /MaxDrop="6.72558" /score="21.9965704" /energy="-10.5" /TU="NA" /idTUdmin="U2617" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2858736..2858755) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2858757) /Source="Nicolas_upshifts" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2858771..2858774) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2858793..2858812 /Source="Nicolas_upshift_promotors" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2858802 /Source="Nicolas_upshifts" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="upshifts" CDS 2858835..2859617 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9302996; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molybdate-binding lipoprotein" /protein_id="NP_391218.1" /db_xref="EnsemblGenomes-Gn:BSU33380" /db_xref="EnsemblGenomes-Tr:CAB15343" /db_xref="GOA:O32208" /db_xref="InterPro:IPR005950" /db_xref="SubtiList:BG14094" /db_xref="UniProtKB/Swiss-Prot:O32208" /translation="MFKKYSIFIAALTAFLLVAGCSSNQSSTDSEKKVTLTISAAASA QDALEEIQKNYEKDHQHITIQDNYGSSGALQKQISQGAGADLFFSAAEDKFKKLVDDG DIAKKDSTELVGNEIVLVVPKNGDSPVTSFSNLAESEKIALGTPESVPAGAYGKESLT KLSLWDKVKDKIVYGKDVRQVLSYVETGNVDAGVVYKTDALVSKKVNIVDEAKADTHS PIVYPLGIVKDTKHRKEAKEFYEYLQSDEAMKVFEKYGFTAE*" /label="modA CDS" gene 2858835..2859617 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /label="modA gene" CDS 2859589..2860281 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="molybdenum transport permease" /protein_id="NP_391219.3" /db_xref="EnsemblGenomes-Gn:BSU33390" /db_xref="EnsemblGenomes-Tr:CAB15344" /db_xref="GOA:O32209" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011867" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14095" /db_xref="UniProtKB/Swiss-Prot:O32209" /translation="MRNMALLPSSISASEFFTPVVLSFQVAAVAGIVVIILGTLAGAW MSRASFFGKTALETCFMLPLVLPPTVVGFILIVIFGKHSFIGQAIEWIFQQPVIFTWW AAVIASAVVAFPLMYQSAKTGFADIDPDIQGAAMVDGASRWKVFIHISVPLAYPSLLT GSILSLARALGEFGATLMFAGNIPGVTQTLPTAIYVALDSGNNTLAWAWVVCIVVISF LMLFFIQQKKTH*" /label="modB CDS" gene 2859589..2860281 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /label="modB gene" downshifts 2860273 /Source="Nicolas_upshifts" /id="D1730" /incds=0 /nref=40 /ntot=195 /MaxReadThrough="0.43895" /MaxDrop="4.92503" /score="19.0609965" /energy="-9.4" /TU="NA" /idTUdmin="U2618" /TUdmin=9 /isTUend="TRUE" /label="downshifts" CDS complement(2860312..2861142) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /EC_number="1.1.1.283" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544192, 16232966, 17114254, 19585557" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544192, 16232966, 17114254, 19585557; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous glyoxal/methylglyoxal reductase" /protein_id="NP_391220.1" /db_xref="EnsemblGenomes-Gn:BSU33400" /db_xref="EnsemblGenomes-Tr:CAB15345" /db_xref="GOA:O32210" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3D3F" /db_xref="PDB:3F7J" /db_xref="SubtiList:BG14096" /db_xref="UniProtKB/Swiss-Prot:O32210" /translation="MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNG YRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQ LDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPM VNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVI LRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF *" /label="pgoN CDS" gene complement(2860312..2861142) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /label="pgoN gene" downshifts complement(2860318) /Source="Nicolas_upshifts" /id="D1731" /incds=0 /nref=190 /ntot=269 /MaxReadThrough="4.7445" /MaxDrop="7.9269" /score="27.8070829" /energy="-9.7" /TU="U2620" /idTUdmin="U2620" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2861005..2861009 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2861025..2861029 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2861034 /Source="Nicolas_upshifts" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2861144 /Source="Nicolas_upshifts" /id="D1732" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="0.95687" /MaxDrop="4.12116" /score="31.5807071" /energy="-11.6" /TU="NA" /idTUdmin="U2618" /TUdmin=880 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2861172..2861191) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2861190) /Source="Nicolas_upshifts" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2861206..2861213) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2861298..2861304 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2861318 /Source="Nicolas_upshifts" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2861319..2861337 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2861365..2861850 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 22307285, 25217289; Product type f: factor" /codon_start=1 /transl_table=11 /product="exported stress induced factor" /protein_id="NP_391221.1" /db_xref="EnsemblGenomes-Gn:BSU33410" /db_xref="EnsemblGenomes-Tr:CAB15346" /db_xref="SubtiList:BG14097" /db_xref="UniProtKB/Swiss-Prot:O32211" /translation="MKRIRIPMTLALGAALTIAPLSFASAEENPAPKMSQTTTAGTTA ADVGLNVNLDVLGIANQIADAIKSAQNRDGFVKNLMESSFYASGQKYNVMVFNLSQEY EDHLNGVQFYGSAVYDGITYGIWVFEDGTFTNKGDGGWINWAFRGWFDRDGSTVAFHR P*" /label="yvgO CDS" gene 2861365..2861850 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /label="yvgO gene" downshifts 2861849 /Source="Nicolas_upshifts" /id="D1733" /incds=0 /nref=18 /ntot=93 /MaxReadThrough="3.44281" /MaxDrop="6.83046" /score="31.5807071" /energy="-11.6" /TU="U2621" /idTUdmin="U2621" /TUdmin="-571" /isTUend="FALSE" /label="downshifts" CDS complement(2861894..2863906) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16021482, 16850406, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16021482, 16850406, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_391222.1" /db_xref="EnsemblGenomes-Gn:BSU33420" /db_xref="EnsemblGenomes-Tr:CAB15347" /db_xref="GOA:O32212" /db_xref="InterPro:IPR004705" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR018422" /db_xref="SubtiList:BG14098" /db_xref="UniProtKB/Swiss-Prot:O32212" /translation="MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFP QGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNLRAPILLLALGLVFATVIVGGYT IHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLV AFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTM HMLIQILTPFVIYLAAEEIGVSGILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNI ILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITFTLMLLRFLWVLFFW NGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILF LAAGVILCTLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNK TASLAVIAEYNEKMKNLRFQQYTSSNRIKKHERKVRAQGVKAEQEALMKMLERGDIPE ETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNEAGLIRA TRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLE VKLKAVQAIRNEIQTLFEEREISRDISHELRQYINDVEAAMLEGGE*" /label="nhaK CDS" gene complement(2861894..2863906) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /label="nhaK gene" downshifts complement(2861902) /Source="Nicolas_upshifts" /id="D1734" /incds=0 /nref=118 /ntot=238 /MaxReadThrough="2.66359" /MaxDrop="5.82216" /score="41.6492295" /energy="-13.2" /TU="NA" /idTUdmin="U2622" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(2863572..2863576) /Source="Nicolas_upshift_promotors" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2863574) /Source="Nicolas_upshifts" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2863907..2864058) /Source="Nicolas_S_feature" /locus_tag="new_3430344_3430495_c" /HighExp="dia5, T0.30H, T-0.40H, Salt, Diami, T1.0H, T0.0H, T1.30H, dia15, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.746, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1281" misc_feature complement(2864035..2864053) /Source="Nicolas_upshift_promotors" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2864058) /Source="Nicolas_upshifts" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2864161..2865876) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (hemoprotein beta-subunit)" /protein_id="NP_391223.1" /db_xref="EnsemblGenomes-Gn:BSU33430" /db_xref="EnsemblGenomes-Tr:CAB15348" /db_xref="GOA:O32213" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR011786" /db_xref="InterPro:IPR036136" /db_xref="SubtiList:BG14099" /db_xref="UniProtKB/Swiss-Prot:O32213" /translation="MVTKILKAPDGSPSDVERIKKESDYLRGTLKEVMLDRISAGIPD DDNRLMKHHGSYLQDDRDLRNERQKQKLEPAYQFMLRVRMPGGVSTPEQWLVMDDLSQ KYGNGTLKLTTRETFQMHGILKWNMKKTIQTIHSALLDTIAACGDVNRNVMCASNPYQ SEIHSEVYEWSKKLSDDLLPRTRAYHEIWLDEERVAGTPEEEVEPMYGPLYLPRKFKI GIAVPPSNDIDVFSQDLGFIAIVEDGKLIGFNVAIGGGMGMTHGDTATYPQLAKVIGF CRPEQMYDVAEKTITIQRDYGNRSVRKNARFKYTVDRLGLENVKEELENRLGWSLEEA KPYHFDHNGDRYGWVEGIEDKWHFTLFVEGGRITDYDDYKLMTGLREIAKVHTGEFRL TANQNLMIANVSSDKKEEISALIEQYGLTDGKHYSALRRSSMACVALPTCGLAMAEAE RYLPTLLDKIEEIIDENGLRDQEITIRMTGCPNGCARHALGEIGFIGKAPGKYNMYLG AAFDGSRLSKMYRENIGEADILSELRILLSRYAKEREEGEHFGDFVIRAGIIKATTDG TNFHD*" /label="cysI CDS" gene complement(2864161..2865876) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /label="cysI gene" downshifts complement(2864168) /Source="Nicolas_upshifts" /id="D1735" /incds=0 /nref=211 /ntot=254 /MaxReadThrough="3.28258" /MaxDrop="6.31358" /score="23.5256972" /energy="-13.8" /TU="U2624" /idTUdmin="U2624" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" CDS complement(2865902..2867719) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (flavoprotein alpha-subunit)" /protein_id="NP_391224.1" /db_xref="EnsemblGenomes-Gn:BSU33440" /db_xref="EnsemblGenomes-Tr:CAB15349" /db_xref="GOA:O32214" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010199" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14100" /db_xref="UniProtKB/Swiss-Prot:O32214" /translation="MQLQVMNSPFNQEQAELLNRLLPTLTESQKIWLSGYLSAQSVSA QEAAGTPAAAVSAEAPAPAVSKEVTVLYGSQTGNAQGLAENAGKQLEQSGFQVTVSSM SDFKPNQLKKVTNLLIVVSTHGEGEPPDNALSFHEFLHGRRAPKLEDLRFSVLALGDS SYEFFCQTGKEFDQRLEELGGKRISPRVDCDLDYDEPAAEWLEGVLKGLNEAGGGSAA PAPAAASQTGESSYSRTNPFRAEVLENLNLNGRGSNKETRHVELSLEGSGLTYEPGDS LGVYPENDPELVELLLKEMNWDPEEIVTLNKQGDVRPLKEALISHYEITVLTKPLLEQ AAQLTGNDELRELLAPGNEENVKAYIEGRDLLDLVRDYGPFSVSAQEFVSILRKMPAR LYSIASSLSANPDEVHLTIGAVRYDAHGRERKGVCSILCAERLQPGDTLPVYVQHNQN FKLPKDPETPIIMVGPGTGVAPFRSFMQEREETGAEGKAWMFFGDQHFVTDFLYQTEW QNWLKDGVLTKMDVAFSRDTEEKVYVQHRMLEHSAELFEWLQEGAAVYICGDEKHMAH DVHNTLLEIIEKEGNMSREEAEAYLADMQQQKRYQRDVY*" /label="cysJ CDS" gene complement(2865902..2867719) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /label="cysJ gene" promotor_-10 complement(2867761..2867780) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2867770..2867777 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2867780) /Source="Nicolas_upshifts" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" upshifts 2867783 /Source="Nicolas_upshifts" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2867790..2867809 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2867793..2867800) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2867890..2870214) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544244, 24520113" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544244, 24520113; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription factor" /protein_id="NP_391225.1" /db_xref="EnsemblGenomes-Gn:BSU33450" /db_xref="EnsemblGenomes-Tr:CAB15350" /db_xref="GOA:O32215" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="SubtiList:BG14101" /db_xref="UniProtKB/Swiss-Prot:O32215" /translation="MNQQDKEWKEEQSRIDEVLKELEKKERFLETSAGGLKHDIIGLR KSFWEDVKVNFDDAHEAIETMASIKQQAELLSDREHNHRRMDQQLKRIHQLKKSPYFG RIDFIENGEEQAERIYIGLASCLDEKEEHFLIYDWRAPISSLYYNYSPGKAEYEVPGE TIEGEMVLKRQFMIKNGTLKAMFNTDMTIGDEMLQEVLSHHSDTQMKNIVSTIQKEQN QIIRNEKSKILIVQGAAGSGKTSAALQRVAYLLYRHRGVIDAGQIVLFSPNFLFNSYV SSVLPELGEENMEQATFQEYIEHRLGRKFKCESPFDQLEYCLTETKGGDFPTRLAGIT WKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQIQSYFYSLDQNHSIPNRM EQTAKWLLSELNKLEKKERRKDWVVHEAELLDKEDYLDVYKKLQERKRFSESTFNDYQ REQQLLAAIIVKKAFKPLKQAVRLLAFLDVTQLYLQLFSGWGGKFQHEKMDAIGELTR SAFTDNKLLYEDAAPFLYMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFPAA SMTVLGDINQSIYAHTINGDQRMDACFEDEPAEYVRLKRTYRSTRQIVEFTKAMLQDG ADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKGHETIAVICKTAHQCIQAHA HMSEYTDVRLIHKENQPFQKGVCVIPVYLAKGIEFDAVLVYDASEEHYHTEHDRRLLY TACTRAMHMLAVFYTGEASPFVTAVPPHLYQIAE*" /label="helD CDS" gene complement(2867890..2870214) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /label="helD gene" downshifts complement(2867908) /Source="Nicolas_upshifts" /id="D1736" /incds=0 /nref=26 /ntot=168 /MaxReadThrough="1.20405" /MaxDrop="4.59044" /score="18.6044234" /energy="-8.5" /TU="NA" /idTUdmin="U2628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2870234..2870241 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2870256..2870275 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2870257..2870272) /Source="Nicolas_upshift_promotors" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2870260 /Source="Nicolas_upshifts" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2870262) /Source="Nicolas_upshifts" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2870307..2870326) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2870316) /Source="Nicolas_upshifts" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2870342..2870348) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2870352..2870371) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2870372) /Source="Nicolas_upshifts" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2870385..2870393) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2870399) /Source="Nicolas_upshifts" /id="D1737" /incds=0 /nref=19 /ntot=158 /MaxReadThrough="2.30604" /MaxDrop="4.26839" /score="16.6103553" /energy="-9.2" /TU="NA" /idTUdmin="U2630" /TUdmin=17 /isTUend="TRUE" /label="downshifts" CDS complement(2870412..2871020) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391226.1" /db_xref="EnsemblGenomes-Gn:BSU33460" /db_xref="EnsemblGenomes-Tr:CAB15351" /db_xref="GOA:O32216" /db_xref="InterPro:IPR005115" /db_xref="SubtiList:BG14102" /db_xref="UniProtKB/Swiss-Prot:O32216" /translation="MAWELLSVIGIIAFAVSGAIVAMEEEYDILGVYILGIVTAFGGG AIRNLLIGVPVSALWEQGAYFQIALLSITIVFLFPKLLLKHWNKWGNLSDAIGLAAFA IQGALYAVKMGHPLSAVIVAAVLTGSGGGIIRDLLAGRKPLVLKAEIYAVWAALGGLI VGLGWLGNSFGLYVLFFVLVVCRVCSYMFNWKLPNRSFRLDN*" /label="yvgT CDS" gene complement(2870412..2871020) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /label="yvgT gene" promotor_-10 complement(2871059..2871078) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2871076) /Source="Nicolas_upshifts" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2871094..2871098) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2871207..2871623) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391227.1" /db_xref="EnsemblGenomes-Gn:BSU33470" /db_xref="EnsemblGenomes-Tr:CAB15352" /db_xref="GOA:O32217" /db_xref="InterPro:IPR003752" /db_xref="InterPro:IPR012187" /db_xref="InterPro:IPR023380" /db_xref="SubtiList:BG14103" /db_xref="UniProtKB/Swiss-Prot:O32217" /translation="MKNRIVFLYASWVVALIAMLGSLYFSEIRKFIPCELCWYQRILM YPLVLILGIATFQGDTRVKKYVLPMAIIGAFISIMHYLEQKVPGFSGIKPCVSGVPCS GQYINWFGFITIPFLALIAFILIIIFMCLLKGEKSE*" /label="bdbC CDS" gene complement(2871207..2871623) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /label="bdbC gene" downshifts complement(2871217) /Source="Nicolas_upshifts" /id="D1738" /incds=0 /nref=120 /ntot=264 /MaxReadThrough="1.31968" /MaxDrop="6.21723" /score="26.5991603" /energy="-12.7" /TU="NA" /idTUdmin="U2631" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2871628..2872296) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11744713, 11872755, 12637552, 15661011, 17501922, 19535335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11744713, 11872755, 12637552, 15661011, 17501922, 19535335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391228.1" /db_xref="EnsemblGenomes-Gn:BSU33480" /db_xref="EnsemblGenomes-Tr:CAB15353" /db_xref="GOA:O32218" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:3EU3" /db_xref="PDB:3EU4" /db_xref="PDB:3GH9" /db_xref="PDB:3GHA" /db_xref="SubtiList:BG14104" /db_xref="UniProtKB/Swiss-Prot:O32218" /translation="MKKKQQSSAKFAVILTVVVVVLLAAIVIINNKTEQGNDAVSGQP SIKGQPVLGKDDAPVTVVEFGDYKCPSCKVFNSDIFPKIQKDFIDKGDVKFSFVNVMF HGKGSRLAALASEEVWKEDPDSFWDFHEKLFEKQPDTEQEWVTPGLLGDLAKSTTKIK PETLKENLDKETFASQVEKDSDLNQKMNIQATPTIYVNDKVIKNFADYDEIKETIEKE LKGK*" /label="bdbD CDS" gene complement(2871628..2872296) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /label="bdbD gene" promotor_-10 complement(2872348..2872367) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2872363) /Source="Nicolas_upshifts" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2872374) /Source="Nicolas_upshifts" /id="D1739" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="7.34296" /MaxDrop="3.6233" /score="12.4442247" /energy="-11.3" /TU="U2632" /idTUdmin="U2633" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2872381..2872386) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2872416..2874524) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /EC_number="3.6.3.3" /EC_number="3.6.3.5" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Cd(II), Zn(II) and Co(II) exporter (ATPase)" /protein_id="NP_391229.3" /db_xref="EnsemblGenomes-Gn:BSU33490" /db_xref="EnsemblGenomes-Tr:CAB15354" /db_xref="GOA:O32219" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14105" /db_xref="UniProtKB/Swiss-Prot:O32219" /translation="MRLVKQEYVLDGLDCSNCARKIENGVKGIKGINGCAVNFAASTL TVSADGKEEQWVTNKVEKKVKSIDPHVTVRQKHIKKSADDGYRNRMVNMLIRMAAAVI LGAAAYLVQSGTIEFFLFLGAYLIIGGDIIIRAVKNIIRGQVFDEHFLMALATIGAFL IQQYPEGVAVMLFYQIGELFQGAAVSRSRKSISALMDIRPDYANLKTKNGIEQVSSED VQTGDIIVVNPGESIPLDGKVVQGSAMVDTSALTGESVPRKAAEGQDVMSGFINQNGV LHIEVTKGYQESAVSKILDLVQNASSRKARTENFITKFAKYYTPAVVIIAVLLAFVPP LVLSGAALSDWVYRALIFLVISCPCALVVSIPLGFFGGIGAASKAGVLVKGSNYLEAL NQVKYAVFDKTGTLTKGSFEVTEIKPAEGFTKDRLLEAAAYAELHSQHPIAESVRKAY GKMLSSDEIESYEEISGHGIFAKVNGTEILAGNKKLMEREQIEDVPDENAGTIVHVAV DQRYAGAIIIADEIKEDAAQAVADLKSLGIKQTAMLTGDSKQTGEAVGKQLGIGEVYA ELLPQDKVAQVEALEAKLLPSEKLIFVGDGINDTPVLARADIGVAMGGLGSDAAVEAA DIVLMTDQPSKIAEAIRIAKRTRRIVWQNIGFALGVKAIFLILGAFGIATMWEAVFSD VGVTLLAVANAMRVMRLKNK*" /label="cadA CDS" gene complement(2872416..2874524) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /label="cadA gene" S_feature complement(2874516..2874617) /Source="Nicolas_S_feature" /locus_tag="new_3440953_3441054_c" /HighExp="dia5, LBGtran, LBGstat, Diami, LBGexp, Gly, Lbtran, T0.30H, M40t45, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 0.999" /TUlongSig="SigB" /TUlongPSig="0.587" /label="S1282" promotor_-10 complement(2874611..2874630) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2874617) /Source="Nicolas_upshifts" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2874646..2874653) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2874684..2877092) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /EC_number="3.6.3.54" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper transporter ATPase" /protein_id="NP_391230.2" /db_xref="EnsemblGenomes-Gn:BSU33500" /db_xref="EnsemblGenomes-Tr:CAB15355" /db_xref="GOA:O32220" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="PDB:1JWW" /db_xref="PDB:1KQK" /db_xref="PDB:1OPZ" /db_xref="PDB:1OQ3" /db_xref="PDB:1OQ6" /db_xref="PDB:1P6T" /db_xref="PDB:2RML" /db_xref="PDB:2VOY" /db_xref="SubtiList:BG14106" /db_xref="UniProtKB/Swiss-Prot:O32220" /translation="MSEQKEIAMQVSGMTCAACAARIEKGLKRMPGVTDANVNLATET SNVIYDPAETGTAAIQEKIEKLGYHVVTEKAEFDIEGMTCAACANRIEKRLNKIEGVA NAPVNFALETVTVEYNPKEASVSDLKEAVDKLGYKLKLKGEQDSEAAAKKKEERKQTA RLIFSAVLSFPLLWAMVSHFTFTSFIWVPDIFLNPWMQFALATPVQFLIGWPFYVGAY KALRNKSANMDVLVALGTTAAYAYSLYLTFQSIGSHGHTDGLYYETSAILLTLILLGK LFETKAKGRSSDAIKKLMKLQAKTATVVRDGQEQIIPIDEVLVNDIVYVKPGERIPVD GEVVEGRSAVDESMITGESLPVDKNPGDSVTGSTVNANGFLKIKAVNVGKDTALSHII KIVEEAQGSKAPIQRLADQISGIFVPIVLGIAVLTFLIWYLWAAPGDFAEAISKFIAV LVIACPCALGLATPTSIMAGSGRAAEFGILFKGGEHLEKTHRLDTIVLDKTGTVTNGK PRLTDAIPFGRFEEKDLLQFAAAAETGSEHPLGEAIIAGVKDKGLEIPKLTRFEAKVG AGILAEAGGKSILVGTRKLMESEQVEHGALLAQMEELEAEGKTVMLVSIDGEAAGLVA VADTIKDTSRKAVARLKELGLDVIMMTGDNRRTAEAIAKEAGIANIIAEVLPEQKAAE IARLQKEGRQTAMVGDGINDAPALATADIGMAIGTGTDIAMETADITLIRGDLNSIAD AIRMSRLTMKNIKQNLFWALGYNSLGIPIAALGFLAPWIAGAAMAFSSVSVVLNALRL QKVK*" /label="copA CDS" gene complement(2874684..2877092) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /label="copA gene" downshifts complement(2874706) /Source="Nicolas_upshifts" /id="D1740" /incds=0 /nref=15 /ntot=68 /MaxReadThrough="5.02116" /MaxDrop="3.63756" /score="26.9828242" /energy="-7.9" /TU="U2633" /idTUdmin="U2635" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2874772) /Source="Nicolas_upshifts" /id="D1741" /incds=1 /nref=52 /ntot=227 /MaxReadThrough="5.93949" /MaxDrop="4.28993" /score="26.9828242" /energy="-7.9" /TU="U2633,U2635" /idTUdmin="U2635" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2877093..2877175) /Source="Nicolas_S_feature" /locus_tag="new_3443530_3443612_c" /HighExp="Diami, dia5, dia15, Gly, T0.30H, Heat, T1.0H, T1.30H, T0.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.999, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S1283" CDS complement(2877176..2877385) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344; Product type f: factor" /codon_start=1 /transl_table=11 /product="copper insertion chaperone and transporter component" /protein_id="NP_391231.1" /db_xref="EnsemblGenomes-Gn:BSU33510" /db_xref="EnsemblGenomes-Tr:CAB15356" /db_xref="GOA:O32221" /db_xref="InterPro:IPR000428" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR036163" /db_xref="PDB:1K0V" /db_xref="PDB:1P8G" /db_xref="PDB:2QIF" /db_xref="PDB:3I9Z" /db_xref="SubtiList:BG14107" /db_xref="UniProtKB/Swiss-Prot:O32221" /translation="MEQKTLQVEGMSCQHCVKAVETSVGELDGVSAVHVNLEAGKVDV SFDADKVSVKDIADAIEDQGYDVAK*" /label="copZ CDS" gene complement(2877176..2877385) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /label="copZ gene" promotor_-10 complement(2877409..2877428) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-10" upshifts complement(2877430) /Source="Nicolas_upshifts" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="upshifts" promotor_-35 complement(2877441..2877447) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-35" CDS complement(2877459..2877764) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17143269, 18048925, 22904286, 24831014, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17143269, 18048925, 22904286, 24831014, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of copper utilisation proteins-Cu(I)" /protein_id="NP_391232.1" /db_xref="EnsemblGenomes-Gn:BSU33520" /db_xref="EnsemblGenomes-Tr:CAB15357" /db_xref="GOA:O32222" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG14108" /db_xref="UniProtKB/Swiss-Prot:O32222" /translation="MEKHNEHKTLNHKSSKEKDQITNRLKRIEGQVRGIQNMVENDRY CVDILVQISAVQAAMKNVALHLLEDHAHHCVADAIKSGDGEQAISELLDVFKKFTKS* " /label="csoR CDS" gene complement(2877459..2877764) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /label="csoR gene" misc_feature 2877728..2877747 /Source="Nicolas_upshift_promotors" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2877739 /Source="Nicolas_upshifts" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2877778..2877797) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-10" upshifts complement(2877804) /Source="Nicolas_upshifts" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="upshifts" promotor_-35 complement(2877811..2877817) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-35" promotor_-35 2877856..2877862 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2877877..2877895 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2877885 /Source="Nicolas_upshifts" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2877892..2878968 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /EC_number="1.1.1.371" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15937154, 20133360, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 20133360, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NADP(+)-dependent)" /protein_id="NP_391233.1" /db_xref="EnsemblGenomes-Gn:BSU33530" /db_xref="EnsemblGenomes-Tr:CAB15358" /db_xref="GOA:O32223" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="PDB:3GDO" /db_xref="PDB:3GFG" /db_xref="SubtiList:BG14057" /db_xref="UniProtKB/Swiss-Prot:O32223" /translation="MITLLKGRRKVDTIKVGILGYGLSGSVFHGPLLDVLDEYQISKI MTSRTEEVKRDFPDAEVVHELEEITNDPAIELVIVTTPSGLHYEHTMACIQAGKHVVM EKPMTATAEEGETLKRAADEKGVLLSVYHNRRWDNDFLTIKKLISEGSLEDINTYQVS YNRYRPEVQARWREKEGTATGTLYDLGSHIIDQTLHLFGMPKAVTANVMAQRENAETV DYFHLTLDYGKLQAILYGGSIVPANGPRYQIHGKDSSFIKYGIDGQEDALRAGRKPED DSWGADVPEFYGKLTTIRGSDKKTETIPSVNGSYLTYYRKIAESIREGAALPVTAEEG INVIRIIEAAMESSKEKRTIMLEH*" /label="iolW CDS" gene 2877892..2878968 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /label="iolW gene" downshifts 2878955 /Source="Nicolas_upshifts" /id="D1742" /incds=0 /nref=155 /ntot=248 /MaxReadThrough="2.17322" /MaxDrop="6.48885" /score="-5.36701412" /energy="-19.4" /TU="NA" /idTUdmin="U2636" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2879005..2879640) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17284825, 17725564, 18208493" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17284825, 17725564, 18208493; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:dichloroindophenol oxidoreductase (2-methylhydroquinone resistance)" /protein_id="NP_391234.1" /db_xref="EnsemblGenomes-Gn:BSU33540" /db_xref="EnsemblGenomes-Tr:CAB15359" /db_xref="GOA:O32224" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14058" /db_xref="UniProtKB/Swiss-Prot:O32224" /translation="MAKVLYITAHPHDEATSYSMATGKAFIESYKEANPNDEVVHIDL YKENIPHIDADVFSGWGKLQSGTGFEELSESEKAKVGRLGELSDQFASADKYVFVTPL WNFSFPPVMKAYLDSVAVAGKSFKYTEQGPVGLLTDKKAIHIQARGGYYSEGPAAEME MGHRYIGIMMNFFGVPSFDGIFVEGHNAEPDKAQQIKEDAIARAKEAGKTF*" /label="azoRB CDS" gene complement(2879005..2879640) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /label="azoRB gene" downshifts complement(2879018) /Source="Nicolas_upshifts" /id="D1743" /incds=0 /nref=211 /ntot=263 /MaxReadThrough="1.58189" /MaxDrop="6.89477" /score="31.0885268" /energy="-15.4" /TU="NA" /idTUdmin="U2637" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2879641..2879738) /Source="Nicolas_S_feature" /locus_tag="new_3446078_3446175_c" /HighExp="Heat, UNK1, G/S, Salt, HiTm, GM-0.1, MG 25, SMM, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1284" promotor_-10 complement(2879718..2879737) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2879738) /Source="Nicolas_upshifts" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2879751..2879757) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2879800..2881695) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12107147, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391235.1" /db_xref="EnsemblGenomes-Gn:BSU33550" /db_xref="EnsemblGenomes-Tr:CAB15360" /db_xref="GOA:O32225" /db_xref="SubtiList:BG14059" /db_xref="UniProtKB/Swiss-Prot:O32225" /translation="MNKTAANNQRIMPIVKDAFRIHANPFPWKKAIGSGFASGFPVLV GALAGHTDYGLIASIGGFVYLYAGGESYKKRALKLLLVSIGIALSFGLGTLLSGMLWM MAAVLGLIGAAAMFIFSALGIQGPAPMFFVLAFLVSSGLPADPSQALFRAGLTFLGGI FAMGIALIGWLWNKHGPEGAVLQKTYHQLAACLSAVGTPGFHNAQHQTVLMLRTARQT VLGKGNRRKKSRHDERFFRLLEKADDIFIAIIHFSAETPDRETAQIEKALRQTGDMLA NARVFNTFQINENESEPRRKLFEEINEVLYIASGRFDKQLDGEPSRLPSSFYFLRNAF DWKSPVLIRALKYGIVLFAADMFALAFGFARSYWIPLSAAAVMLGTTVVFTLHRAIQR SAGTVIGVILAGAILFFKPGGVYIAFCIAALQCLLEMLIVRNYALAVPFLTANALVIT ESMHGGAGAGYFMIARLTDVAVGSVIGLLGTMLLWRRFSTKRLPELVRNVIRLEGQFM EKLLTGQIADEHKLRVSLVRLRDAYDKALGEFPHANADALWPAISGAQHLGYYLLSAQ AHRRPSAPFSDEEINQLRAFFEQAEQSFIMKRMPADIQVPHVPHYPRISKELSALYSG LRTAFEK*" /label="yvaC CDS" gene complement(2879800..2881695) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /label="yvaC gene" promotor_-10 complement(2881746..2881757) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2881746) /Source="Nicolas_upshifts" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2881772..2881778) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2881845) /Source="Nicolas_upshifts" /id="D1744" /incds=0 /nref=20 /ntot=155 /MaxReadThrough="2.49984" /MaxDrop="4.21522" /score="11.4033831" /energy="-8" /TU="NA" /idTUdmin="U2639" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2881858..2882259) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391236.1" /db_xref="EnsemblGenomes-Gn:BSU33560" /db_xref="EnsemblGenomes-Tr:CAB15361" /db_xref="GOA:O32226" /db_xref="InterPro:IPR020348" /db_xref="SubtiList:BG14060" /db_xref="UniProtKB/Swiss-Prot:O32226" /translation="MRYMKLFFLVTDIGFILYWLSAGFSLIPESWAFKHHDHPFMIAW NWSFFPLDILISVTGLYSLYLQRVNRADWKLMALISLVLTCCSGLQALSFWTFSSDFD LVWWLFNGYLLIYPLFFIHLLLKEGRRTKQS*" /label="yvaD CDS" gene complement(2881858..2882259) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /label="yvaD gene" CDS complement(2882256..2882615) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948170, 15849754, 16850406, 19549332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite-efflux transporter" /protein_id="NP_391237.1" /db_xref="EnsemblGenomes-Gn:BSU33570" /db_xref="EnsemblGenomes-Tr:CAB15362" /db_xref="GOA:O32227" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG14061" /db_xref="UniProtKB/Swiss-Prot:O32227" /translation="MNWVFLCLAILFEVAGTVSMKLSSGFTKLIPSLLLIFFYGGSLF FLTLTLKSIDVSVAYAVWSGMGIVLITVVGFLFFQEHVSVMKVISIGLIIAGVVSLNL IEHVAVSEPVHKSGQYK*" /label="yvaE CDS" gene complement(2882256..2882615) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /label="yvaE gene" CDS complement(2882612..2883184) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391238.1" /db_xref="EnsemblGenomes-Gn:BSU33580" /db_xref="EnsemblGenomes-Tr:CAB15363" /db_xref="GOA:O32228" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14062" /db_xref="UniProtKB/Swiss-Prot:O32228" /translation="MDKRILAETFRLIKQKGFSFTMNDLAAALGTSKRTLYAYYSSKD QLVEAVVEQFIAEMKQIERDIYENESLNVLEKVKQMLISLPQGMELLNMGLLNELKKY HYDAWLTLDAFIKEEWAIVLALLNECKQQKRIRNINPDLFVHMYIGSINQVYDPEYPL KHQFTTGEVLESIVDVLFNGITADEEADAT*" /label="yvaF CDS" gene complement(2882612..2883184) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /label="yvaF gene" promotor_-10 complement(2883222..2883241) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2883227) /Source="Nicolas_upshifts" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2883255..2883262) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2883295..2884089) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391239.1" /db_xref="EnsemblGenomes-Gn:BSU33590" /db_xref="EnsemblGenomes-Tr:CAB15364" /db_xref="GOA:O32229" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14063" /db_xref="UniProtKB/Swiss-Prot:O32229" /translation="MKLNLQGKTALVTGSTSGIGKAIASSLAEEGAAVIINGRREEKV NQTIDELKTQHAEAVLYPAAFDLGTEEGCNELFQAYPEVDILVNNLGIFEPAEYFDIP DDEWFRFFEVNIMSGVRLTRRYLHNMIEKKEGRVIFIASEAAIMPSQEMAHYSATKTM QLSISRSLAELATGTNVTVNTVMPGSTLTEGVETMLNSLYPGENLTVQEAEARFMKEN RPTSIIQRLIRPEEIAHFVTFLSSPLSSAINGAALRADGGLVRSVF*" /label="yvaG CDS" gene complement(2883295..2884089) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /label="yvaG gene" promotor_-10 complement(2884110..2884128) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2884122) /Source="Nicolas_upshifts" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2884143..2884149) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2884155..2884174) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2884166) /Source="Nicolas_upshifts" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2884168..2884233) /Source="Nicolas_S_feature" /locus_tag="new_3450605_3450670_c" /HighExp="H2O2, Heat, Diami, G180, Paraq, dia15, Oxctl, BMM, G135, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.47, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="0.996, 1" /label="S1285" promotor_-35 complement(2884188..2884195) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2884275..2884634) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /product="transfer-messenger RNA (tmRNA, 10Sa RNA)" /experiment="publication(s) with functional evidences, PMID:11395451, 11918677, 14766921, 17369301, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11918677, 14766921, 17369301, 18673456" /label="ssrA RNA" gene complement(2884275..2884634) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /label="ssrA gene" downshifts complement(2884278) /Source="Nicolas_upshifts" /id="D1745" /incds=0 /nref=260 /ntot=272 /MaxReadThrough="4.32959" /MaxDrop="9.81359" /score="26.7868133" /energy="-15.8" /TU="U2642,U2644" /idTUdmin="U2643" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2884618..2884626) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2884628) /Source="Nicolas_upshifts" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2884641..2884646) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2884686..2884705) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2884694) /Source="Nicolas_upshifts" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2884696..2884760) /Source="Nicolas_S_feature" /locus_tag="new_3451133_3451197_c" /HighExp="Etha, C90, dia5, dia15, Diami, T0.0H, T-0.40H, T-1.40H, LPhT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.997, 0.996, 1" /TUlongSig="SigB, SigA" /TUlongPSig="0.999, 0.753" /label="S1286" promotor_-35 complement(2884718..2884722) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2884760) /Source="Nicolas_upshifts" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="upshifts" promotor_-10 complement(2884761..2884780) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-10" promotor_-35 complement(2884795..2884802) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-35" CDS complement(2884811..2885281) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10947848, 11395451, 11918677, 12682299, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10947848, 11395451, 11918677, 12682299, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="tmRNA-binding protein" /protein_id="NP_391240.1" /db_xref="EnsemblGenomes-Gn:BSU33600" /db_xref="EnsemblGenomes-Tr:CAB15365" /db_xref="GOA:O32230" /db_xref="InterPro:IPR000037" /db_xref="InterPro:IPR020081" /db_xref="InterPro:IPR023620" /db_xref="SubtiList:BG14064" /db_xref="UniProtKB/Swiss-Prot:O32230" /translation="MPKGSGKVLSQNKKANHDYFIEETYETGIVLQGTEIKSIRAGRV NLKDSFAKIERGEVFLHNMHVSPYEQGNRYNHDPLRTRKLLMHRKEINKLIGLTKEKG YSLVPLKLYLKNGFAKVLLGLGKGKKNYDKREDLKRKDAKREIERAFRDSQKGF*" /label="smpB CDS" gene complement(2884811..2885281) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /label="smpB gene" promotor_no_box 2885108..2885208 /Source="Nicolas_upshift_promotors" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2885168 /Source="Nicolas_upshifts" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2885278 /Source="Nicolas_upshifts" /id="D1746" /incds=0 /nref=2 /ntot=105 /MaxReadThrough="0.62459" /MaxDrop="3.18501" /score="-9.3042809" /energy="-3.3" /TU="NA" /idTUdmin="U2647" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2885326..2885345) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(2885332) /Source="Nicolas_upshifts" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" S_feature complement(2885334..2885425) /Source="Nicolas_S_feature" /locus_tag="new_3451771_3451862_c" /HighExp="Etha, S8, Cold, S7, G135, G180, G150, H2O2, M9-stat, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig="0.753" /label="S1287" promotor_-35 complement(2885361..2885364) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" CDS complement(2885426..2887765) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /EC_number="3.1.13.1" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 19215769, 22333191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 19215769, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease R" /protein_id="NP_391241.1" /db_xref="EnsemblGenomes-Gn:BSU33610" /db_xref="EnsemblGenomes-Tr:CAB15366" /db_xref="GOA:O32231" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004476" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR011805" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013223" /db_xref="InterPro:IPR022966" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14065" /db_xref="UniProtKB/Swiss-Prot:O32231" /translation="MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVK ALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHAKGFAFLLPEDTSLSDVFIPPNE LNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKI TSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHK HGLPGEFPADAMEQASSTPDTIDEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKL DDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPMIPHRLSNGICSLNP KVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPL VPMFKDMERLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEE FMLVANETVAEHFHWMNVPFIYRIHEEPNAEKLQKFLEFVTTFGYVVKGTAGNIHPRA LQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPIRRYPDL IVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYML DKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNV FRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPRELDSSRSRKRGKPARKRVQSTN TPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK*" /label="rnr CDS" gene complement(2885426..2887765) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /label="rnr gene" promotor_-35 2886526..2886529 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2886545..2886548 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2886554 /Source="Nicolas_upshifts" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2887784..2888524) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1369099, 17369301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase" /protein_id="NP_391242.2" /db_xref="EnsemblGenomes-Gn:BSU33620" /db_xref="EnsemblGenomes-Tr:CAB15367" /db_xref="GOA:O32232" /db_xref="InterPro:IPR012354" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14066" /db_xref="UniProtKB/Swiss-Prot:O32232" /translation="MKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYT CHAPQYEGHGVPPEELVHTGPEDWWKNVMDGYEYLKSEGYESIAACGLSLGGVFSLKL GYTVPIKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTPM NTLKALQDLIADVRNNVDMIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYE ESGHVITLDKERDLVHQDVYEFLEKLDW*" /label="estA CDS" gene complement(2887784..2888524) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /label="estA gene" promotor_-10 complement(2888180..2888198) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-10" upshifts complement(2888192) /Source="Nicolas_upshifts" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="upshifts" promotor_-35 complement(2888213..2888219) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-35" misc_feature complement(2888552..2888570) /Source="Nicolas_upshift_promotors" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2888566) /Source="Nicolas_upshifts" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="upshifts" downshifts complement(2888654) /Source="Nicolas_upshifts" /id="D1747" /incds=0 /nref=30 /ntot=212 /MaxReadThrough="6.16751" /MaxDrop="5.2246" /score="-4.14736839" /energy="-9.1" /TU="U2650" /idTUdmin="U2649" /TUdmin="-3234" /isTUend="FALSE" /label="downshifts" CDS complement(2888656..2888886) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10074070, 10644701, 16243836" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074070, 10644701, 16243836; Product type f: factor" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_391243.1" /db_xref="EnsemblGenomes-Gn:BSU33630" /db_xref="EnsemblGenomes-Tr:CAB15368" /db_xref="GOA:O32233" /db_xref="InterPro:IPR004692" /db_xref="SubtiList:BG14067" /db_xref="UniProtKB/Swiss-Prot:O32233" /translation="MHAVLITLLVIVSIALIIVVLLQSSKSAGLSGAISGGAEQLFGK QKARGLDLILHRITVVLAVLFFVLTIALAYIL*" /label="secG CDS" gene complement(2888656..2888886) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /label="secG gene" promotor_-10 complement(2888916..2888935) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(2888937) /Source="Nicolas_upshifts" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" promotor_-35 complement(2888950..2888953) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" promotor_-35 2888975..2888981 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2888995..2889006 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2888996 /Source="Nicolas_upshifts" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="upshifts" CDS 2889035..2889805 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391244.1" /db_xref="EnsemblGenomes-Gn:BSU33640" /db_xref="EnsemblGenomes-Tr:CAB15369" /db_xref="GOA:O32234" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14068" /db_xref="UniProtKB/Swiss-Prot:O32234" /translation="MPLISIDSRKHLFYEEYGQGIPIIFIHPPGMGRKVFYYQRLLSK HFRVIFPDLSGHGDSDHIDQPASISYYANEIAQFMDALHIDKAVLFGYSAGGLIAQHI GFTRPDKVSHLILSGAYPAVHNVIGQKLHKLGMYLLEKNPGLLMKILAGSHTKDRQLR SILTDHMKKADQAHWHQYYLDSLGYNCIEQLPRLEMPMLFMYGGLRDWTFTNAGYYRR SCRHAEFFRLEYQGHQLPTKQWKTCNELVTGFVLTHHS*" /label="yvaM CDS" gene 2889035..2889805 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /label="yvaM gene" promotor_-35 2889057..2889065 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2889076..2889094 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2889106 /Source="Nicolas_upshifts" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2889845..2890078) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional regulator" /protein_id="NP_391245.1" /db_xref="EnsemblGenomes-Gn:BSU33650" /db_xref="EnsemblGenomes-Tr:CAB15370" /db_xref="GOA:O32235" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG14159" /db_xref="UniProtKB/Swiss-Prot:O32235" /translation="MPVEKIQIRRDYVLQYMVNNDYSLNQLALEIGVSPATLSRVLNG ERRPGQLVIGKMLHYFNLKFEDLFYYDFVDKSQ*" /label="yvzC CDS" gene complement(2889845..2890078) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /label="yvzC gene" promotor_-35 2890169..2890176 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-35" upshifts 2890184 /Source="Nicolas_upshifts" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="upshifts" promotor_-10 2890188..2890207 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-10" CDS 2890230..2890637 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_391246.1" /db_xref="EnsemblGenomes-Gn:BSU33660" /db_xref="EnsemblGenomes-Tr:CAB15371" /db_xref="GOA:O32236" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14069" /db_xref="UniProtKB/Swiss-Prot:O32236" /translation="MESFGEQLRALREERKLTVNQLATYSGVSAAGISRIENGKRGVP KPATIKKLAEALKIPYEGLMYKAGYIEEVHEARAPYETKCKLLEKAEAYDLKNLALLE NEKWQYLNKEDLLMLDHYFSFISDEAKKRSADD*" /label="rghRA CDS" gene 2890230..2890637 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /label="rghRA gene" CDS 2890667..2891086 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional repressor" /protein_id="NP_391247.1" /db_xref="EnsemblGenomes-Gn:BSU33670" /db_xref="EnsemblGenomes-Tr:CAB15372" /db_xref="GOA:O32237" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14070" /db_xref="UniProtKB/Swiss-Prot:O32237" /translation="MSPFGQQLRELRRARKLTVNQLAVYSGISSATISKIENGKRGTP KPATIKKLAAVLKVPYENLMAAAGHIQAFPEEIREASEGYQSVYEIYQTAVTRGAEHL PIFNSQKWEHLSKQDIENLSKYFDFLSSEAKKRASSS*" /label="rghRB CDS" gene 2890667..2891086 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /label="rghRB gene" promotor_-35 2891124..2891131 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2891145..2891164 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2891152 /Source="Nicolas_upshifts" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 2891178..2891504 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20639328; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catechol dioxygenase" /protein_id="NP_391248.2" /db_xref="EnsemblGenomes-Gn:BSU33680" /db_xref="EnsemblGenomes-Tr:CAB15373" /db_xref="GOA:O32238" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14071" /db_xref="UniProtKB/Swiss-Prot:O32238" /translation="MNQSEMCPRFEKAVDILSKRWVALIVFQLLNGSQRFSEIEAALP NLSGRVLSERLKELELEGVVKRDVIPETPVRIEYSLTDKGKALAPILGEISKWATEWI DPSFLD*" /label="catR CDS" gene 2891178..2891504 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /label="catR gene" S_feature 2891505..2891589 /Source="Nicolas_S_feature" /locus_tag="new_3457942_3458026" /HighExp="Cold, H2O2, Diami, LBGstat, LPhT, dia15, G180, Paraq, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.985" /label="S1288" promotor_-35 2891560..2891567 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2891580..2891598 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2891591 /Source="Nicolas_upshifts" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 2891629..2893329 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8188684, 11872722, 27899502; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative methyl-accepting transducer" /protein_id="NP_391249.1" /db_xref="EnsemblGenomes-Gn:BSU33690" /db_xref="EnsemblGenomes-Tr:CAB15374" /db_xref="GOA:O32239" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR024478" /db_xref="InterPro:IPR035440" /db_xref="SubtiList:BG14072" /db_xref="UniProtKB/Swiss-Prot:O32239" /translation="MRLTISRKFSLVFLTLILINLLVGGIGVLNMQHIIQKTDEINTK WIDGIKGITSINYVTEHLSSKEKDFLIYTDKSKMDTLDQEMNQIMEDINQKLDNYEKT ISTDKEQKLFEQLQTKVNTYMDIHAQIIESGRTNDMDKARGLLVQTEASFEDMKKTIT QLVDLNQEGSNTAVKETKAVYHKGLIYTALLVAASILISIFIWLYITRNIVKPIIRMK ESANHIAEGDLSNDMEALNSKDELGDLNEALQKMVGNLRDIVGYSKDISSRVLSSSQV LATATNETRSGSKHITETMNEMAEGSEQQAQDAVTIAESMNEFTESIDKAYNHGITIS DTSQNVLELAVSGNENMATSLQQMKTIHHIVEEAVHKVRSLEQHSQDINKLVQVINGI AEQTNLLSLNAAIEAARAGESGKGFAVVAEEVRKLADGVSDSVQDITRIVNGTQQEIH TVITYLESSFTEVEKGTENLTDTGQAMQHIKQSVTHVADSIKEVTDGLKQLTNQSITI NQSIENIASVSEESAAGIEETFSITEQSAHSMDQVLLNAEELEQLANELNEKMGQFTI *" /label="yvaQ CDS" gene 2891629..2893329 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /label="yvaQ gene" S_feature complement(2892345..2893338) /Source="Nicolas_S_feature" /locus_tag="new_3458782_3459775_c" /HighExp="S6, S5, S7, C30, S8, S4, S3, LoTm, BT, B36" /AntisenseName="yvaQ" /AntisenseCor="-0.38660715434937498" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1289" downshifts 2893307 /Source="Nicolas_upshifts" /id="D1748" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="1.43789" /MaxDrop="3.86744" /score="26.1532813" /energy="-12.2" /TU="NA" /idTUdmin="U2655" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2893369..2894049) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391250.1" /db_xref="EnsemblGenomes-Gn:BSU33700" /db_xref="EnsemblGenomes-Tr:CAB15375" /db_xref="GOA:P39775" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12636" /db_xref="UniProtKB/Swiss-Prot:P39775" /translation="MNVLEQLMTYYAQNGSYVMDEFGRHFLMSAYGVLFAAVVGVPAG ILIAHFRRLSAWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDMIVRGSNATNGTAIILAGAIPTAVMAVGADLLMAWLERALSPVKKKRTG AKHVQSAA*" /label="opuBD CDS" gene complement(2893369..2894049) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /label="opuBD gene" downshifts complement(2893383) /Source="Nicolas_upshifts" /id="D1749" /incds=0 /nref=119 /ntot=171 /MaxReadThrough="3.12805" /MaxDrop="5.39624" /score="35.0134287" /energy="-12.2" /TU="NA" /idTUdmin="U2657" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2893743..2893749 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2893764..2893782 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2893769..2896520 /Source="Nicolas_S_feature" /locus_tag="new_3460206_3462957" /HighExp="Sw, M9-stat, B60, Salt, LoTm, T0.30H, BC, Gly, B36, T1.0H" /AntisenseName="opuBC" /AntisenseCor="-0.13125567572652899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1290" upshifts 2893769 /Source="Nicolas_upshifts" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2894066..2894986) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (choline-binding lipoprotein)" /protein_id="NP_391251.1" /db_xref="EnsemblGenomes-Gn:BSU33710" /db_xref="EnsemblGenomes-Tr:CAB15376" /db_xref="GOA:Q45462" /db_xref="InterPro:IPR007210" /db_xref="PDB:3R6U" /db_xref="SubtiList:BG12635" /db_xref="UniProtKB/Swiss-Prot:Q45462" /translation="MKRKYLKLMIGLALAATLTLSGCSLPGLSAAADQTIKIGAQSMS ESEIIASMLGQLIEHHTDLKTTTIKNLGSNAVQQQALMNGEIDIAATRYTGDALTGTL RMEPEKDPDKALALTQREFKKRYDLKWYDSYGFDNTYAFTVSKELADQYHLETVSDVK KWAPQLKLGVDNYWMKLKGNGYQDFTKTYGMTFGGTYPMQIGLVYDAVKSGKMDIVLA YSTDGRIKSYGLKMLKDDKQFFPPYDCSPVVPEKVLKEHPELEGIIKKMLGKIDTATM QELNYEVDGNLKEPSVVAKEYLEKHRYFES*" /label="opuBC CDS" gene complement(2894066..2894986) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /label="opuBC gene" CDS complement(2894998..2895651) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391252.1" /db_xref="EnsemblGenomes-Gn:BSU33720" /db_xref="EnsemblGenomes-Tr:CAB15377" /db_xref="GOA:Q45461" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12634" /db_xref="UniProtKB/Swiss-Prot:Q45461" /translation="MHHIVQFLQTNGGELLYKTYEHITISLIAVILGVLVAVPLGVVL TRMKKGAGTIIGIVNIIQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIRGVNKNLLESGKGIGMTPAEQVRLVELPLAAPVIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIVIDYVLAVAERKLTPAGMQRLKELS* " /label="opuBB CDS" gene complement(2894998..2895651) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /label="opuBB gene" CDS complement(2895668..2896813) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 18321243, 21658392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 18321243, 21658392; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (ATP-binding protein)" /protein_id="NP_391253.1" /db_xref="EnsemblGenomes-Gn:BSU33730" /db_xref="EnsemblGenomes-Tr:CAB15378" /db_xref="GOA:Q45460" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12633" /db_xref="UniProtKB/Swiss-Prot:Q45460" /translation="MLTLENVSKTYKGGKKAVNNVNLKIAKGEFICFIGPSGCGKTTT MKMINRLIEPSAGKIFIDGENIMDQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEQQRKERARELLKLVDMGPEYVDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQKTLHKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDDILRNPADEFVEEFIGKERLIQSSSPDVERVDQIMNTQPVTITADKTLSEAIQLM RQERVDSLLVVNDERVLQGYVDVEIIDQCRKKANLVSEVLHEDIYTVLGGTLLRDTVR KILKRGVKYVPVVDEDRRLIGIVTRASLVDIVYDSLWGEEKQLAALS*" /label="opuBA CDS" gene complement(2895668..2896813) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /label="opuBA gene" S_feature complement(2896814..2896881) /Source="Nicolas_S_feature" /locus_tag="new_3463251_3463318_c" /HighExp="T5.0H, T3.30H, T3.0H, T-5.40H, T4.0H, T-0.40H, T-1.40H, T2.30H, T-3.40H, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1291" upshifts complement(2896881) /Source="Nicolas_upshifts" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2896882..2896901) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2896912..2896916 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2896916..2896919) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2896932..2896950 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2896937 /Source="Nicolas_upshifts" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2897032..2897036 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2897052..2897071 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2897055 /Source="Nicolas_upshifts" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" CDS 2897097..2897630 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (controlling choline uptake)" /protein_id="NP_391254.2" /db_xref="EnsemblGenomes-Gn:BSU33740" /db_xref="EnsemblGenomes-Tr:CAB15379" /db_xref="GOA:C0SPB8" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14073" /db_xref="UniProtKB/Swiss-Prot:C0SPB8" /translation="MEKDPLTIIEQAEDHFIERIAENMHAFGMPSTVGRVLGIIYMNR KPMTLTELSEATGMSKTRMSQVVREMLDANIAEKVFEKGVRKDLYEVEQDYYQTFITL FSATWSKVVSKNKMMHKKLNRELLSVLDEELTPEAEEKVNELLKELKEWLDYYNWLSR LIEFFESEDIFKYVPKP*" /label="yvaV CDS" gene 2897097..2897630 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /label="yvaV gene" S_feature complement(2897297..>2897696) /Source="Nicolas_S_feature" /locus_tag="new_3463734_3464253_c" /HighExp="S8, Cold, C30, GM 25, GM 60, BC, T-4.40H, M/G, GM-0.1, MG 120" /AntisenseName="yvaV" /AntisenseCor="-7.6123637680436104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.503, 1, 0.758" /TUlongSig="NA" /TUlongPSig="NA" /label="S1292" downshifts 2897619 /Source="Nicolas_upshifts" /id="D1750" /incds=0 /nref=51 /ntot=161 /MaxReadThrough="2.68472" /MaxDrop="4.69377" /score="-3.5823381" /energy="-8.6" /TU="NA" /idTUdmin="U2659" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(2897696,2897703) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs14" N_region 2897697..2897702 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs14" S_feature <2897703..2897778 /Source="Nicolas_S_feature" /locus_tag="new_3466412_3467550" /HighExp="Pyr, S8, nit, C30, GM 150, M9-stat, S7, S2, G/S, S1" /AntisenseName="sdpI" /AntisenseCor="-7.9710115369408502E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.636, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1297" S_feature complement(<2897703..2897769) /Source="Nicolas_S_feature" /locus_tag="new_3467393_3467541_c" /HighExp="Salt, B36, Gly, B60, LoTm, S8, GM 5, MG 25, Cold, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1298" CDS complement(2897774..2898463) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391260.1" /db_xref="EnsemblGenomes-Gn:BSU33800" /db_xref="EnsemblGenomes-Tr:CAB15385" /db_xref="GOA:O34742" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12640" /db_xref="UniProtKB/Swiss-Prot:O34742" /translation="MEVLQQLGTYYSQNGGYVLQEFYRHFLMSVYGVLFAAIVGIPLG ILIARYRRLSGWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDIIVRGSNATNGTAIILAGAIPTALMAVIADLVMGWLERALSPIKKKKGN FIIADRKTTSI*" /label="opuCD CDS" gene complement(2897774..2898463) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /label="opuCD gene" downshifts complement(2897814) /Source="Nicolas_upshifts" /id="D1757" /incds=0 /nref=95 /ntot=199 /MaxReadThrough="5.55394" /MaxDrop="6.7177" /score="8.72167152" /energy="-11.6" /TU="U2667" /idTUdmin="U2667" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" promotor_-35 2898406..2898414 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2898428..2898447 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2898442 /Source="Nicolas_upshifts" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2898481..2899392) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 28256787; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (osmoprotectant-binding lipoprotein)" /protein_id="NP_391261.1" /db_xref="EnsemblGenomes-Gn:BSU33810" /db_xref="EnsemblGenomes-Tr:CAB15386" /db_xref="GOA:O32243" /db_xref="InterPro:IPR007210" /db_xref="PDB:3PPN" /db_xref="PDB:3PPO" /db_xref="PDB:3PPP" /db_xref="PDB:3PPQ" /db_xref="PDB:3PPR" /db_xref="SubtiList:BG12639" /db_xref="UniProtKB/Swiss-Prot:O32243" /translation="MTKIKWLGAFALVFVMLLGGCSLPGLGGASDDTIKIGAQSMTES EIVANMIAQLIEHDTDLNTALVKNLGSNYVQHQAMLGGDIDISATRYSGTDLTSTLGK EAEKDPKKALNIVQNEFQKRFSYKWFDSYGFDNTYAFTVTKKFAEKEHINTVSDLKKN ASQYKLGVDNAWLKRKGDGYKGFVSTYGFEFGTTYPMQIGLVYDAVKNGKMDAVLAYS TDGRIKAYDLKILKDDKRFFPPYDCSPVIPEKVLKEHPELEGVINKLIGQIDTETMQE LNYEVDGKLKEPSVVAKEFLEKHHYFD*" /label="opuCC CDS" gene complement(2898481..2899392) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /label="opuCC gene" CDS complement(2899412..2900065) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391262.1" /db_xref="EnsemblGenomes-Gn:BSU33820" /db_xref="EnsemblGenomes-Tr:CAB15387" /db_xref="GOA:O34878" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12638" /db_xref="UniProtKB/Swiss-Prot:O34878" /translation="MNQMMTFLQTNGGELLYKTGEHLYISLIAVVLGIIVAVPLGVAL TRMKKGAGAVIGFVNIVQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIKGVNKNLLESGKGIGMTGWEQIRLVEIPLAIPIIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIIIDYVLAVTERKVTPKGLQGMKEVS* " /label="opuCB CDS" gene complement(2899412..2900065) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /label="opuCB gene" CDS complement(2900088..2901230) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10216873, 9925583, 21658392, 27378384, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216873, 9925583, 21658392, 27378384, 27683249; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (ATP-binding protein)" /protein_id="NP_391263.1" /db_xref="EnsemblGenomes-Gn:BSU33830" /db_xref="EnsemblGenomes-Tr:CAB15388" /db_xref="GOA:O34992" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12637" /db_xref="UniProtKB/Swiss-Prot:O34992" /translation="MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTT MKMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDEILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMR EKRVDSLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRK ILKQGIKYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI*" /label="opuCA CDS" gene complement(2900088..2901230) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /label="opuCA gene" promotor_-10 complement(2901274..2901293) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-10" upshifts complement(2901289) /Source="Nicolas_upshifts" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="upshifts" promotor_-35 complement(2901308..2901311) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-35" promotor_-35 2901427..2901434 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2901447..2901466 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2901458 /Source="Nicolas_upshifts" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="upshifts" CDS 2901494..2902051 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23960087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23960087; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative transcriptional regulator of choline uptake systems" /protein_id="NP_391264.1" /db_xref="EnsemblGenomes-Gn:BSU33840" /db_xref="EnsemblGenomes-Tr:CAB15389" /db_xref="GOA:O34709" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14079" /db_xref="UniProtKB/Swiss-Prot:O34709" /translation="MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNR KPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISL FAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLS RLIEFFESEEVFRYVPKTKECSSLK*" /label="opcR CDS" gene 2901494..2902051 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /label="opcR gene" S_feature 2902052..2902816 /Source="Nicolas_S_feature" /locus_tag="new_3471824_3472588" /HighExp="HiOs, GM 5, GM 10, Salt, MG 15, MG 10, MG 25, T0.0H, T-2.40H, GM 45" /AntisenseName="yvbG" /AntisenseCor="-0.14921239095219299" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1299" CDS complement(2902069..2902704) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391265.1" /db_xref="EnsemblGenomes-Gn:BSU33850" /db_xref="EnsemblGenomes-Tr:CAB15390" /db_xref="GOA:O32244" /db_xref="InterPro:IPR002771" /db_xref="SubtiList:BG14080" /db_xref="UniProtKB/Swiss-Prot:O32244" /translation="MMFSFIVHVFISLFAVSNPIGNVPIFLTLTEGYTAAERKAIARK AAILSFFILAAFLVFGHLIFKLFDINIHALRVAGGIFIFGIAYNLLNAKESHVQSLHH DEHKESKEKADISVTPLSIPIIAGPGTIATVMSLSAGHSGIGHYAAVMIGIAAVIALT FLFFHYSAFISSKLGKTEMNVITRLMGLILAVVAVGMIGAGLKGMFPVLTS*" /label="yvbG CDS" gene complement(2902069..2902704) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /label="yvbG gene" downshifts complement(2902082) /Source="Nicolas_upshifts" /id="D1758" /incds=0 /nref=21 /ntot=50 /MaxReadThrough="2.02169" /MaxDrop="4.45088" /score="10.9231366" /energy="-16.4" /TU="NA" /idTUdmin="U2669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2902745..2902763) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2902751) /Source="Nicolas_upshifts" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2902779..2902785) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2902790..2902797 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2902809..2902828 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2902818 /Source="Nicolas_upshifts" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 2902854..2903468 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391266.1" /db_xref="EnsemblGenomes-Gn:BSU33860" /db_xref="EnsemblGenomes-Tr:CAB15391" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR021722" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG14081" /db_xref="UniProtKB/Swiss-Prot:O32245" /translation="MFKKIAADALGLSDIGKIIEPQDYDKTDADDYVMHEDNEKIYFL IKTKADEYCFTNLALIHVDGERATSSKRTLKRYPYSQYKISDVFLETAGKVDLDVEIK FKLGGEQFDIDVHKDQIEKLKDLYKALLRIAETTYENDILINQAEQSLDKAVTILHHT RPEHVNIETQYKELTEFGFTWLTSVRSQYHIKDFGDVFEKYINN*" /label="yvbH CDS" gene 2902854..2903468 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /label="yvbH gene" downshifts 2903454 /Source="Nicolas_upshifts" /id="D1759" /incds=0 /nref=110 /ntot=197 /MaxReadThrough="2.66824" /MaxDrop="5.86088" /score="-4.16829989" /energy="-7.9" /TU="U2670" /idTUdmin="U2668" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 2903522..2903525 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2903540..2903559 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2903548 /Source="Nicolas_upshifts" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 2903600..2904298 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391267.1" /db_xref="EnsemblGenomes-Gn:BSU33870" /db_xref="EnsemblGenomes-Tr:CAB15392" /db_xref="GOA:O32246" /db_xref="InterPro:IPR029038" /db_xref="SubtiList:BG14082" /db_xref="UniProtKB/Swiss-Prot:O32246" /translation="MYCPQCGHQTDGGNFCEKCGSPLPGQSGHQHAAQTGAAAKQAAK QFGSFVLSVLKRPYQECKATGGEQLISAIITMVLFSLLTPLMFYILFSDGPGSVSFTA IFLEPTIYFILFLFGLHACIFFALKIAGNQVSFKDSFSRFGAFLIPFTAILILALFFF LLHTDICFTILAVGLIGAFFAIPPAMLSSYQHSYKGKVDFIYSTIVIYLIICVTFQLI IEHYVKEIFRYMLF*" /label="yvbI CDS" gene 2903600..2904298 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /label="yvbI gene" downshifts 2904271 /Source="Nicolas_upshifts" /id="D1760" /incds=0 /nref=72 /ntot=203 /MaxReadThrough="1.50622" /MaxDrop="4.71846" /score="17.2112529" /energy="-17.2" /TU="U2671" /idTUdmin="U2671" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(2904334..2906151) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15155184" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391268.1" /db_xref="EnsemblGenomes-Gn:BSU33880" /db_xref="EnsemblGenomes-Tr:CAB15393" /db_xref="GOA:O32247" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR026870" /db_xref="SubtiList:BG14083" /db_xref="UniProtKB/Swiss-Prot:O32247" /translation="MLFCKNCGSQNNEGAKFCKQCGTPIGGGSKQANQETASTAETRQ APRKPIPKKTIILWSSIAAACVILFAAYKTGAYFTSKDRLVDKFEQAVNDGDQDQIAT LLTPVNDNLKLTKNNVKPFLTYLKDHPDKKDELFASLRDETAQKDIVYAEKDGKSLLV FDHYDLKVAPVYFEVSSNYKNTDLYVNKEEAGSVKKADQAQTLGPYIPGEYTVSAKLK NDVVDLVKKEDIQAIGDSSFRVDLSLEADDVTFSLANDIKSGKGDLLINGKSIHKDPF KSVTYGPLLTDGSMTASVEAEFPWGKTKTAGVPIDDKEMELTLIPDQDTQEQIMNTIV KTTKQYSKALSDGNTAQMTEASANWKAETKDTVDSMKSADSYLKDRYLETDFDLDTFA LSQKNDGTWQVSVTGKELHQSSSYNDYTKSEMTDDSPSYEYLLSYDKKQKKWIFEDAE STFESAGTNIKKIKNDKPETYTSAWAGSKNKGSESSASGDVTDEQVTLFMGSYLQSQA DAVNQNNFSLMEDSLEKGSSLYSDQQHLVSKLNKEGTTEDFNNYEVKSWSQNGSAITI KTYEEFYITKSGGSPKLRTYNWTYTGVVKNGRIYLTSIQ*" /label="yvbJ CDS" gene complement(2904334..2906151) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /label="yvbJ gene" downshifts complement(2904353) /Source="Nicolas_upshifts" /id="D1761" /incds=0 /nref=31 /ntot=189 /MaxReadThrough="2.6958" /MaxDrop="3.67366" /score="15.9345511" /energy="-17.2" /TU="NA" /idTUdmin="U2673" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2904524) /Source="Nicolas_upshifts" /id="D1762" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="4.6758" /MaxDrop="2.2812" /score="15.9345511" /energy="-17.2" /TU="U2673" /idTUdmin="U2673" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" misc_feature complement(2906193..2906212) /Source="Nicolas_upshift_promotors" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 2906197..2906216 /Source="Nicolas_upshift_promotors" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2906202 /Source="Nicolas_upshifts" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2906206) /Source="Nicolas_upshifts" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2906271..2906738 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acyltransferase" /protein_id="NP_391269.1" /db_xref="EnsemblGenomes-Gn:BSU33890" /db_xref="EnsemblGenomes-Tr:CAB15394" /db_xref="GOA:O32248" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YVK" /db_xref="SubtiList:BG14084" /db_xref="UniProtKB/Swiss-Prot:O32248" /translation="MNMQKLRIELGEETNDELYDLLLLADPSKDIVDEYLERGECYTA WAGDELAGVYVLLKTRPQTVEIVNIAVKESLQKKGFGKQLVLDAIEKAKKLGADTIEI GTGNSSIHQLSLYQKCGFRIQAIDHDFFLRHYDEDIFENGIQCRDMVRLYLDL*" /label="yvbK CDS" gene 2906271..2906738 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /label="yvbK gene" downshifts 2906735 /Source="Nicolas_upshifts" /id="D1763" /incds=0 /nref=199 /ntot=250 /MaxReadThrough="1.84358" /MaxDrop="5.3321" /score="15.9040274" /energy="-13.3" /TU="U2672" /idTUdmin="U2672" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(2906783..2908075) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /EC_number="4.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enolase" /protein_id="NP_391270.1" /db_xref="EnsemblGenomes-Gn:BSU33900" /db_xref="EnsemblGenomes-Tr:CAB15395" /db_xref="GOA:P37869" /db_xref="InterPro:IPR000941" /db_xref="InterPro:IPR020809" /db_xref="InterPro:IPR020810" /db_xref="InterPro:IPR020811" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:4A3R" /db_xref="SubtiList:BG10899" /db_xref="UniProtKB/Swiss-Prot:P37869" /translation="MPYIVDVYAREVLDSRGNPTVEVEVYTETGAFGRALVPSGASTG EYEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELLGFDVTEQNAIDQLLIELDGTEN KGKLGANAILGVSMACARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNV DIQEFMIMPVGAPNFREALRMGAQIFHSLKSVLSAKGLNTAVGDEGGFAPNLGSNEEA LQTIVEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLSGEGVVKTSAEMVDWYEE LVSKYPIISIEDGLDENDWEGHKLLTERLGKKVQLVGDDLFVTNTKKLSEGIKNGVGN SILIKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTG APSRTDRVAKYNQLLRIEDQLAETAQYHGINSFYNLNK*" /label="eno CDS" gene complement(2906783..2908075) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /label="eno gene" downshifts complement(2906793) /Source="Nicolas_upshifts" /id="D1764" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="2.21852" /MaxDrop="9.34136" /score="29.8674712" /energy="-15" /TU="NA" /idTUdmin="U2674" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2908105..2909640) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /EC_number="5.4.2.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9830105, 10869096, 12682299, 19193632, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9830105, 10869096, 12682299, 19193632, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate mutase" /protein_id="NP_391271.1" /db_xref="EnsemblGenomes-Gn:BSU33910" /db_xref="EnsemblGenomes-Tr:CAB15396" /db_xref="GOA:P39773" /db_xref="InterPro:IPR005995" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR011258" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR036646" /db_xref="SubtiList:BG10898" /db_xref="UniProtKB/Swiss-Prot:P39773" /translation="MSKKPAALIILDGFGLRNETVGNAVALAKKPNFDRYWNQYPHQT LTASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAIS NAKENNKALHLFGLLSDGGVHSHINHLFALLKLAKKEGLTKVYIHGFLDGRDVGPQTA KTYINQLNDQIKEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSALD VVDDSYANGIYDEFVIPSVITKENGEPVAKIQDGDSVIFYNFRPDRAIQISNTFTNKD FRDFDRGENYPKNLYFVCLTHFSETVDGYVAFKPINLDNTVGEVLSQHGLKQLRIAET EKYPHVTFFMSGGREAEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIEADKH DAIILNFANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAILAKGGHAIITADHGNADI LITESGEPHTAHTTNPVPVIVTKEGITLREGGILGDLAPTLLDLLGVEKPKEMTGTSL IQK*" /label="pgm CDS" gene complement(2908105..2909640) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /label="pgm gene" CDS complement(2909633..2910394) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /EC_number="5.3.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8021172, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="triose phosphate isomerase" /protein_id="NP_391272.1" /db_xref="EnsemblGenomes-Gn:BSU33920" /db_xref="EnsemblGenomes-Tr:CAB15397" /db_xref="GOA:P27876" /db_xref="InterPro:IPR000652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020861" /db_xref="InterPro:IPR022896" /db_xref="InterPro:IPR035990" /db_xref="SubtiList:BG10897" /db_xref="UniProtKB/Swiss-Prot:P27876" /translation="MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPAADKAEAVVCAPA LFLEKLASAVKGTDLKVGAQNMHFEESGAFTGEISPVALKDLGVDYCVIGHSERREMF AETDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNDLVADQVKKGLAGLSEEQVA ASVIAYEPIWAIGTGKSSTAKDANDVCAHIRKTVAESFSQEAADKLRIQYGGSVKPAN IKEYMAESDIDGALVGGASLEPQSFVQLLEEGQYE*" /label="tpiA CDS" gene complement(2909633..2910394) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /label="tpiA gene" CDS complement(2910425..2911609) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /EC_number="2.7.2.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559176, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559176, 12682299, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate kinase" /protein_id="NP_391273.1" /db_xref="EnsemblGenomes-Gn:BSU33930" /db_xref="EnsemblGenomes-Tr:CAB15398" /db_xref="GOA:P40924" /db_xref="InterPro:IPR001576" /db_xref="InterPro:IPR015824" /db_xref="InterPro:IPR015911" /db_xref="InterPro:IPR036043" /db_xref="SubtiList:BG11062" /db_xref="UniProtKB/Swiss-Prot:P40924" /translation="MNKKTLKDIDVKGKVVFCRVDFNVPMKDGEVTDDTRIRAALPTI KHLADQGAKVLLASHLGRPKGEVVEELRLTPVAARLGELLGKEVKKADEAYGDAVKAQ ISEMKDGDVLVLENVRFYPGEEKNDPELAKAFAELADVYVNDAFGAAHRAHASTAGIA EHLPAVAGFLMEKELDVLGKAVSNPDRPFTAIIGGAKVKDKIGVIESLLDKVDNLIIG GGLAYTFVKALGYEVGKSLLEEDKIELAKSFMDRAKEKGVNFYMPEDVLVADDFSNDA NVKIVPISEIPSDLEAIDIGTKTRETYADVIKNSKLVVWNGPMGVFEIDLFAQGTKAV AEALAEAKDTYSVIGGGDSAAAVEKFGLADKMSHISTGGGASLEFMEGKELPGVAALN DK*" /label="pgk CDS" gene complement(2910425..2911609) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /label="pgk gene" S_feature complement(2911610..2911850) /Source="Nicolas_S_feature" /locus_tag="new_3481382_3481622_c" /HighExp="Lbstat, Lbtran, C90, LBGtran, LBGexp, G150, M40t45, LPhT, M0t45, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA, SigK" /TUshortPSig="0.979, 0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1300" upshifts complement(2911850) /Source="Nicolas_upshifts" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2911852..2911925) /Source="Nicolas_S_feature" /locus_tag="new_3481624_3481697_c" /HighExp="C90, LBGtran, Lbstat, LBGexp, Lbtran, G150, M40t45, Etha, ferm, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1301" promotor_-10 complement(2911864..2911883) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2911899..2911903) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2911926..2912933) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /EC_number="1.2.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NAD-dependent, glycolytic)" /protein_id="NP_391274.1" /db_xref="EnsemblGenomes-Gn:BSU33940" /db_xref="EnsemblGenomes-Tr:CAB15399" /db_xref="GOA:P09124" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10827" /db_xref="UniProtKB/Swiss-Prot:P09124" /translation="MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHL LQYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTK RADAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPF AKVLNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSL VLPELKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYS EEPLVSGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYSNRVVDLAAYIAKKG L*" /label="gapA CDS" gene complement(2911926..2912933) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /label="gapA gene" promotor_-35 2912852..2912855 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2912872..2912874 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2912874 /Source="Nicolas_upshifts" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2912980..2914002) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489127, 12622823, 17142398, 17293407, 18052209, 18554327" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489127, 12622823, 17142398, 17293407, 18052209, 18554327; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of gapA" /protein_id="NP_391275.1" /db_xref="EnsemblGenomes-Gn:BSU33950" /db_xref="EnsemblGenomes-Tr:CAB15400" /db_xref="GOA:O32253" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OKG" /db_xref="PDB:3BXE" /db_xref="PDB:3BXF" /db_xref="PDB:3BXG" /db_xref="PDB:3BXH" /db_xref="SubtiList:BG14085" /db_xref="UniProtKB/Swiss-Prot:O32253" /translation="MNQLIQAQKKLLPDLLLVMQKRFEILQYIRLTEPIGRRSLSASL GISERVLRGEVQFLKEQNLVDIKTNGMTLTEEGYELLSVLEDTMKDVLGLTLLEKTLK ERLNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMM TPDSKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSI IEEPSVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFN ADGEVVHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAK KLLRDE*" /label="cggR CDS" gene complement(2912980..2914002) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /label="cggR gene" upshifts complement(2912996) /Source="Nicolas_upshifts" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2913024..2913025) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2914003..2914114) /Source="Nicolas_S_feature" /locus_tag="new_3483775_3483886_c" /HighExp="LPhT, C90, LBGtran, Heat, BI, LBGexp, Lbstat, Sw, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1302" downshifts 2914040 /Source="Nicolas_upshifts" /id="D1765" /incds=0 /nref=3 /ntot=50 /MaxReadThrough="4.48989" /MaxDrop="5.24842" /score="-9.71393179" /energy="-11.8" /TU="NA" /idTUdmin="U2675" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2914095..2914114) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2914114) /Source="Nicolas_upshifts" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2914116..2914226) /Source="Nicolas_S_feature" /locus_tag="new_3483888_3483998_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, S3, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1303" promotor_-35 complement(2914128..2914135) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2914209..2914228) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-10" upshifts complement(2914224) /Source="Nicolas_upshifts" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="upshifts" promotor_-35 complement(2914241..2914250) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-35" CDS complement(2914300..2915694) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9620981, 10417639, 15849754, 16850406, 20693325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620981, 10417639, 15849754, 16850406, 20693325; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arabinose-related compounds permease" /protein_id="NP_391276.1" /db_xref="EnsemblGenomes-Gn:BSU33960" /db_xref="EnsemblGenomes-Tr:CAB15401" /db_xref="GOA:P96710" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11907" /db_xref="UniProtKB/Swiss-Prot:P96710" /translation="MKNTPTQLEPNVPVTRSHSMGFVILISCAAGLGGLLYGYDTAVI SGAIGFLKDLYSLSPFMEGLVISSIMIGGVVGVGISGFLSDRFGRRKILMTAALLFAI SAIVSALSQDVSTLIIARIIGGLGIGMGSSLSVTYITEAAPPAIRGSLSSLYQLFTIL GISATYFINLAVQRSGTYEWGVHTGWRWMLAYGMVPSVIFFLVLLVVPESPRWLAKAG KTNEALKILTRINGETVAKEELKNIENSLKIEQMGSLSQLFKPGLRKALVIGILLALF NQVIGMNAITYYGPEIFKMMGFGQNAGFVTTCIVGVVEVIFTVIAVLLIDKVGRKKLM SIGSAFMAIFMILIGTSFYFELTSGIMMIVLILGFVAAFCVSVGPITWIMISEIFPNH LRARAAGIATIFLWGANWAIGQFVPMMIDSFGLAYTFWIFAVINILCFLFVVTICPET KNKSLEEIEKLWIK*" /label="araE CDS" gene complement(2914300..2915694) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /label="araE gene" downshifts complement(2914314) /Source="Nicolas_upshifts" /id="D1766" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="1.15614" /MaxDrop="3.28809" /score="1.06999853" /energy="-14.6" /TU="NA" /idTUdmin="U2679" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2915793..2915812) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2915807) /Source="Nicolas_upshifts" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2915827..2915834) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2915834..2915841 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2915855..2915874 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2915861 /Source="Nicolas_upshifts" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="upshifts" CDS 2915898..2916986 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the ara regulon (LacI family)" /protein_id="NP_391277.2" /db_xref="EnsemblGenomes-Gn:BSU33970" /db_xref="EnsemblGenomes-Tr:CAB15402" /db_xref="GOA:P96711" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR033532" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3TB6" /db_xref="PDB:4EGY" /db_xref="PDB:4EGZ" /db_xref="PDB:4H0E" /db_xref="PDB:5D4R" /db_xref="PDB:5D4S" /db_xref="SubtiList:BG11913" /db_xref="UniProtKB/Swiss-Prot:P96711" /translation="MLPKYAQVKEEISSWINQGKILPDQKIPTENELMQQFGVSRHTI RKAIGDLVSQGLLYSVQGGGTFVASRSAKSALHSNKTIGVLTTYISDYIFPSIIRGIE SYLSEQGYSMLLTSTNNNPDNERRGLENLLSQHIDGLIVEPTKSALQTPNIGYYLNLE KNGIPFAMINASYAELAAPSFTLDDVKGGMMAAEHLLSLGHTHMMGIFKADDTQGVKR MNGFIQAHRERELFPSPDMIVTFTTEEKESKLLEKVKATLEKNSKHMPTAILCYNDEI ALKVIDMLREMDLKVPEDMSIVGYDDSHFAQISEVKLTSVKHPKSVLGKAAAKYVIDC LEHKKPKQEDVIFEPELIIRQSARKLNE*" /label="araR CDS" gene 2915898..2916986 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /label="araR gene" downshifts 2916966 /Source="Nicolas_upshifts" /id="D1767" /incds=0 /nref=202 /ntot=247 /MaxReadThrough="1.17419" /MaxDrop="4.76041" /score="20.2322165" /energy="-13.6" /TU="NA" /idTUdmin="U2680" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2917035..2918045) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_391278.1" /db_xref="EnsemblGenomes-Gn:BSU33980" /db_xref="EnsemblGenomes-Tr:CAB15403" /db_xref="GOA:O32254" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG14086" /db_xref="UniProtKB/Swiss-Prot:O32254" /translation="MSNNQRKDTLLSVLNLSPVVQGGTIAESFRNSMDLARRAEEWGY HRYWLAEHHNIEGVASSATAVLIGHIAGGTKKIRVGSGGIMLPNHSSLVIAEQFGTLE TLYPGRIDLGLGRAPGTDQLTARALRRNINSGEDFPEQLEELRNYFKPSGNVRNQVRA IPGEGIDVPIWLLGSSGFSARLAGELGLPFAFAAHFSPANTVPALELYRNSFTPSDVL DEPYAMVGVTIIAADTNEKAQHLATSHYQRFLDLVRGTPNQLKPPVEDMDQIWSPYEK AMVNEQLSSTIVGGPEEVKAKLEDFVKTTQADEIMVNSETFEHADRMRSFEIIADVWK NR*" /label="yvbT CDS" gene complement(2917035..2918045) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /label="yvbT gene" downshifts complement(2917042) /Source="Nicolas_upshifts" /id="D1768" /incds=0 /nref=200 /ntot=252 /MaxReadThrough="1.53983" /MaxDrop="7.63266" /score="27.2032847" /energy="-14.2" /TU="NA" /idTUdmin="U2681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2918046..2918123) /Source="Nicolas_S_feature" /locus_tag="new_3487818_3487895_c" /HighExp="dia5, dia15, Diami, H2O2, Salt, Paraq, G180, Etha, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1304" promotor_-10 complement(2918113..2918132) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2918123) /Source="Nicolas_upshifts" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2918146..2918153) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2918202..2919080) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391279.1" /db_xref="EnsemblGenomes-Gn:BSU33990" /db_xref="EnsemblGenomes-Tr:CAB15404" /db_xref="GOA:O32255" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14087" /db_xref="UniProtKB/Swiss-Prot:O32255" /translation="MTITQLKVFVKIAETGSFTKAGQALNMTQPAVSHAISAIEAELD VKLIIRDRRNGLMLTDTGKQILVHIREVLKGIEKVEQVAAAEKGLELGTIHIGTFSTA SAYFMPKLISEFKQKYPKLELVLHEGTVNEVKEWLHTRMIDVGILLYPTEEMEYIHLK KDKMAVVLRDDHPLASHSAITLKDLDHEPMIVCDGGYESPFIDMFRQAGATLHPAFTV YNINTSISMIREGLGLAILSEMSMSGMPLPEHVVTRELDPQVYRDVQLAVPSLKEASL AAKLFIEMAKELFGAE*" /label="yvbU CDS" gene complement(2918202..2919080) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /label="yvbU gene" promotor_-35 2918738..2918744 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2918759..2918770 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2918770 /Source="Nicolas_upshifts" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2919114..2919121 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2919127..2919146) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-10" upshifts complement(2919132) /Source="Nicolas_upshifts" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="upshifts" promotor_-10 2919135..2919154 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2919137 /Source="Nicolas_upshifts" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2919160..2919164) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-35" CDS 2919180..2920097 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10844694, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cysteine and O-acetylserine efflux permease" /protein_id="NP_391280.1" /db_xref="EnsemblGenomes-Gn:BSU34000" /db_xref="EnsemblGenomes-Tr:CAB15405" /db_xref="GOA:O32256" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG14088" /db_xref="UniProtKB/Swiss-Prot:O32256" /translation="MKQLPKTRTALLLAFLVIMWGVNWPLSKAALAYSPPLLFAGIRT LIGGLLLVIVALPRIHKLRLKETWPIYLVSALLNITLFYGLQTIGLNYLPAGLFSAIV FFQPVLMGVFSWLWLGESMFVMKVIGLILGFAGVAVISAAGFGGHISVIGVLLALGSA VSWALGTVYMKKTGSRVDSIWMVALQLTIGSVFLLISGFWTESFSAIQWTAPFITSLL FISVFVIALGWLVFFTLVGSGEASKVASYTFLIPLISIVASSIFLHEPLTLSLLAGLL LIVTSICLVNTKSKAQKAAAIGINEKAAQ*" /label="cyeB CDS" gene 2919180..2920097 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /label="cyeB gene" downshifts 2920086 /Source="Nicolas_upshifts" /id="D1769" /incds=0 /nref=6 /ntot=15 /MaxReadThrough="2.97475" /MaxDrop="3.548" /score="22.9557936" /energy="-19.2" /TU="NA" /idTUdmin="U2684" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2920138..2921481) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19258532, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative leucine permease" /protein_id="NP_391281.1" /db_xref="EnsemblGenomes-Gn:BSU34010" /db_xref="EnsemblGenomes-Tr:CAB15406" /db_xref="GOA:O32257" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG14089" /db_xref="UniProtKB/Swiss-Prot:O32257" /translation="MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPS VIIAYLLGGIILLFIMQGLAEMAVRNRNARTFRDLVQQVLGNYAAYFLDWIYWKMWVL NIAAEAVVAAIFIQYWLPGCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITV IIIFIILGLLLLFVSFGDHTASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEII GVTLAETKNPEKVVPKAVRSTLTRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFK MVGIPGADHIMNAVILLAIISSMNSGLYGSSRILYTQASDGRLPKVFSKLSSKNVPMF AILMCTSSLYIGVLISLFAGSQTFNYLMGSLGYTVLFIWLIIGFAHLKSRKQQTETPA YYVKWFPYTTWFAIVALLAILIGVIMTTSIVITGITAAIYLLITVAYLVKGRKHQ*" /label="yvbW CDS" gene complement(2920138..2921481) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /label="yvbW gene" misc_RNA complement(2921550..2921785) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /product="T-box riboswitch controlling synthesis of an amino acid transporter" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 18625071, 19258532; Product type n: RNA" /function="16.3: Control" /label="tboX RNA" gene complement(2921550..2921785) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /label="tboX gene" downshifts complement(2921684) /Source="Nicolas_upshifts" /id="D1770" /incds=1 /nref=1 /ntot=104 /MaxReadThrough="5.18182" /MaxDrop="2.29735" /score="33.4262209" /energy="-24.4" /TU="U2685,U2689" /idTUdmin="U2689" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2921786..2921882) /Source="Nicolas_S_feature" /locus_tag="new_3491558_3491654_c" /HighExp="Cold, GM 120, C30, GM 90, C90, GM 15, GM 10, GM 25, HPh, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1305" CDS complement(2921883..2922917) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12177332; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative epimerase modification of peptidoglycan" /protein_id="NP_391282.1" /db_xref="EnsemblGenomes-Gn:BSU34020" /db_xref="EnsemblGenomes-Tr:CAB15407" /db_xref="GOA:O32258" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG14090" /db_xref="UniProtKB/Swiss-Prot:O32258" /translation="MKKWLIIAVSLAIAIVLFMYTKGEAKAAGMTVGYTTGDTASYNS LTKYHTYMNAIATDTFAFEKNGQIIGDAPTKQLTYAKKKKIKTWAVISNYNDAIYDFD GDLASRVMSNKTAKKRFTDQLITLAKKHSYYGINIDFEAVNPEDRAAYSNFIQYVSQA LNKKHIKTMVSVPAKSADDKNDDWSWPYDYAKIGKYADFVQVMTYDEHGIWGEPGSVA STNWIKSSLQFSVKKIKANKVIMGIPAYGYDWDVKDGSTSTIREWNELKSLIKKQKAK PAFNKKSGSMTFSYVDKKKHKHVVWYENEKTVQTKSHLAKQYKIAGVSVYALGNESES FWKAIRKGTK*" /label="yvbX CDS" gene complement(2921883..2922917) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /label="yvbX gene" promotor_-10 complement(2922939..2922957) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2922945) /Source="Nicolas_upshifts" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2922970..2922977) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2923025..2923747) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22427629, 24196425, 24274019" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22427629, 24196425, 24274019; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase for L-lactate utilization" /protein_id="NP_391283.1" /db_xref="EnsemblGenomes-Gn:BSU34030" /db_xref="EnsemblGenomes-Tr:CAB15408" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR022823" /db_xref="SubtiList:BG14091" /db_xref="UniProtKB/Swiss-Prot:O32259" /translation="MTKGTIQNQESFLNRIASSLGRERRTGGVAVPEWAHQPQYKTLE GYSADDLVTVLKNHCVKIHTELIETDSTGLYDALREQVSRFSGGPVIIPKDPRFEEYG LKSLLTKDWPSEGTPVWEWDADKGEENIKKAEQANVGITFSEITLAESGTVVLFSSKD IGRSVSLLPTTYIAIVPKSSIVPRMTQASDIIRQNIANGVTVPSCINYITGPSNSADI EMDLVVGVHGPVKAAYILVSDR*" /label="lutC CDS" gene complement(2923025..2923747) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /label="lutC gene" downshifts complement(2923041) /Source="Nicolas_upshifts" /id="D1771" /incds=0 /nref=194 /ntot=266 /MaxReadThrough="4.5919" /MaxDrop="7.41457" /score="25.5917046" /energy="-15.7" /TU="U2689" /idTUdmin="U2689" /TUdmin="-1423" /isTUend="FALSE" /label="downshifts" CDS complement(2923747..2925186) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase linked to L-lactate utilization" /protein_id="NP_391284.1" /db_xref="EnsemblGenomes-Gn:BSU34040" /db_xref="EnsemblGenomes-Tr:CAB15409" /db_xref="GOA:O07021" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR004452" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR022825" /db_xref="InterPro:IPR024569" /db_xref="SubtiList:BG12448" /db_xref="UniProtKB/Swiss-Prot:O07021" /translation="MAMKIGTDAFKERVSQGIDNEFMRGAVSGAQERLRTRRLEAAEE LGNWEEWRSLSEEIRQHVLENLDFYLGQLAENVAKRGGHVYFAKTAEEASSYIRDVIQ KKNGKKIVKSKSMVTEEINLNEVLEKEGCEVVETDLGEYILQIDDHDPPSHIVAPALH KNKEQIRDVFKERLDYQHTEKPEELVMHARAILRKKFLEADIGITGCNFAIADTGSVS LVTNEGNGRLVSTLPKTQITVMGMERIVPSFSEFEVLVSMLTRSAVGQRLTSYITALT GPKLEGEVDGPEEFHLVIVDNGRSNILGTEFQSVLQCIRCAACINVCPVYRHVGGHSY GSIYSGPIGAVLSPLLGGYDDYKELPYASSLCAACSEACPVKIPLHELLLKHRQNIVE KEGRAPISEKLAMKAFGLGASSLSLYKMGSKWAPAAMTPFTEDEKISKGPGPLKNWTQ IRDFPAPHKSRFRDWFADRETSERTKEEQ*" /label="lutB CDS" gene complement(2923747..2925186) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /label="lutB gene" promotor_-35 2924734..2924737 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2924754 /Source="Nicolas_upshifts" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2924755..2924759 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2924908 /Source="Nicolas_upshifts" /id="D1772" /incds=1 /nref=1 /ntot=175 /MaxReadThrough="1.77859" /MaxDrop="3.31917" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2686" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 2925062 /Source="Nicolas_upshifts" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2925063..2925064 /Source="Nicolas_upshift_promotors" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2925213..2925929) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /EC_number="1.8.98.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-sulfur oxidase subunit used in L-lactate utilization" /protein_id="NP_391285.1" /db_xref="EnsemblGenomes-Gn:BSU34050" /db_xref="EnsemblGenomes-Tr:CAB15410" /db_xref="GOA:O07020" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR022822" /db_xref="SubtiList:BG12447" /db_xref="UniProtKB/Swiss-Prot:O07020" /translation="MKVSLFVTCLVDMFQTNVGKATVELLERLGCEVDFPEGQICCGQ PAYNSGYVHDAKKAMKRMIETFQDSEYVVSPSGSCTTMFREYPHLFQDDPKWADKAKK LADKTYELTDFIVNVLGVEDVGATLHTKATLHTSCHMTRLLGVRKEPMKLLSHVKGLQ FTELPGKHNCCGFGGTFSVKMAQISEQMVDEKVECVEETGAEVLIGADCGCLMNIGGR LGRKDKNVKVMHIAEVLNSR*" /label="lutA CDS" gene complement(2925213..2925929) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /label="lutA gene" promotor_-35 2925833..2925840 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2925854..2925856 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2925854 /Source="Nicolas_upshifts" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2925927 /Source="Nicolas_upshifts" /id="D1773" /incds=0 /nref=15 /ntot=169 /MaxReadThrough="1.96527" /MaxDrop="4.662" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2688" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" S_feature complement(2925930..2925996) /Source="Nicolas_S_feature" /locus_tag="new_3495702_3495768_c" /HighExp="C90, M40t90, T3.0H, T4.0H, HiOs, T1.0H, T3.30H, T2.30H, Lbstat, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1306" promotor_-10 complement(2925993..2926012) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-10" upshifts complement(2925996) /Source="Nicolas_upshifts" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="upshifts" promotor_-35 complement(2926027..2926034) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-35" CDS complement(2926104..2926706) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvfT]" /protein_id="NP_391286.1" /db_xref="EnsemblGenomes-Gn:BSU34060" /db_xref="EnsemblGenomes-Tr:CAB15411" /db_xref="GOA:O07019" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12446" /db_xref="UniProtKB/Swiss-Prot:O07019" /translation="MIRLFIAEDQRMLLGALGSLLDLEEDMTVIGQALNGEEALHAIL KLEPDVCIMDIEMPVRSGLNVAEELMKKGCVSKVIILTTFARPGYFERAVKAGAHGYL LKDGEIDDLADAIRKCVKGKRVFSPELTFNMMRDENPLTVREQEILRLAALGKTTKDI TLELYLSQGTVRNYISEIIQKLNAKNRTEAASIAEEKGWI*" /label="yvfU CDS" gene complement(2926104..2926706) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /label="yvfU gene" CDS complement(2926723..2927838) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YvfU]" /protein_id="NP_391287.2" /db_xref="EnsemblGenomes-Gn:BSU34070" /db_xref="EnsemblGenomes-Tr:CAB15412" /db_xref="GOA:Q795K2" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12445" /db_xref="UniProtKB/Swiss-Prot:Q795K2" /translation="MKKAISIFPKEFGFFPYIFLVYTIMPFLSLLKESGVKQGIGYGM LLLFVAAYRQLFCSVGKASFTYWLIVQMAVILMYSVFYNITYIYLGFFPANFVGYYKE KTNFNRAFCALIFILLFPCLYQFIANSVSLRELFSVLPFLVIMLISPFGIRSMFRRIE LEAKLAQANEQIKELSKREERVRIARDLHDTLGHTLSLLTLKSQLIQRLAASDPERTK LEAKEMETSSRSALKQVRELVSDMRTVTITEELVNIQHILRAGNITFQYEGADDFSVI SPVTQNIISMCMREAVTNIIKHSKATHCAITISQFADKMRIVIRDDGKGAPKEKMFGN GLWGMEERLMLIEGGLTVSDHNGTVVALTIPLIKKAE*" /label="yvfT CDS" gene complement(2926723..2927838) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /label="yvfT gene" CDS complement(2927842..2928579) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391288.1" /db_xref="EnsemblGenomes-Gn:BSU34080" /db_xref="EnsemblGenomes-Tr:CAB15413" /db_xref="GOA:O07017" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12444" /db_xref="UniProtKB/Swiss-Prot:O07017" /translation="MNVLQKQSIAEMKRVLRNKYFVLWSLIMPIAFYYFFTNVVNTNV PDQRAWEAHYLMSMTVFSVMGSSIMTLGIRMVQERSQGWAAFIRLTPLPDHIYLSAQM IGQSVIHVLSITVIFLFGAIINDIALSPFEWMMSGLWILFGALPFLALGTLIGLMRKV ETAAGISNVLYMLLALGGGMWMPFEVMPDMMQSIGQWLPSYHFGSGAWELVRGGSPTW KNILILIAYMMLFMLLSKYIRRKQEAV*" /label="yvfS CDS" gene complement(2927842..2928579) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /label="yvfS gene" promotor_-10 complement(2927868..2927887) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-10" upshifts complement(2927882) /Source="Nicolas_upshifts" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="upshifts" promotor_-35 complement(2927899..2927906) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-35" CDS complement(2928580..2929485) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_391289.1" /db_xref="EnsemblGenomes-Gn:BSU34090" /db_xref="EnsemblGenomes-Tr:CAB15414" /db_xref="GOA:O07016" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12443" /db_xref="UniProtKB/Swiss-Prot:O07016" /translation="MMKEAVTVSNVTKHFQRKTAVNNISFSIEKGEIAAILGPNGAGK TTVVSMILGLLKPSEGEIKLFNRVPDDQQVREKIGVMLQEVSVMPGLKVDEILELFRS YYPNPLSMKELVSLTALTKEDLKTRAEKLSGGQKRRLSFALALAGNPELLILDEPTVG MDTSSRHRFWQTIHGLSDQGKTIIFSTHYLQEADDAAQRILFFTEGQLVADGSPMQIR SRIQKQSVSFTLHSSESLERLSCHPEVERVIHEHERTIIQTSNTDKVLALIFQENIHA RDIRIEQATLDEAFRQLADGNREAM*" /label="yvfR CDS" gene complement(2928580..2929485) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /label="yvfR gene" promotor_-10 complement(2929505..2929523) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2929516) /Source="Nicolas_upshifts" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2929539..2929542) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2929694..2929701 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2929712..2929731 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2929719 /Source="Nicolas_upshifts" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="upshifts" CDS 2929769..2930578 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11591687, 12620626, 15632289, 21980452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591687, 12620626, 15632289, 21980452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of RsbP phosphatase" /protein_id="NP_391290.1" /db_xref="EnsemblGenomes-Gn:BSU34100" /db_xref="EnsemblGenomes-Tr:CAB15415" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR031143" /db_xref="PDB:1WOM" /db_xref="PDB:1WPR" /db_xref="SubtiList:BG12442" /db_xref="UniProtKB/Swiss-Prot:O07015" /translation="MNEAILSRNHVKVKGSGKASIMFAPGFGCDQSVWNAVAPAFEED HRVILFDYVGSGHSDLRAYDLNRYQTLDGYAQDVLDVCEALDLKETVFVGHSVGALIG MLASIRRPELFSHLVMVGPSPCYLNDPPEYYGGFEEEQLLGLLEMMEKNYIGWATVFA ATVLNQPDRPEIKEELESRFCSTDPVIARQFAKAAFFSDHREDLSKVTVPSLILQCAD DIIAPATVGKYMHQHLPYSSLKQMEARGHCPHMSHPDETIQLIGDYLKAHV*" /label="rsbQ CDS" gene 2929769..2930578 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /label="rsbQ gene" CDS 2930614..2931825 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /EC_number="3.1.3.3" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine protein-phosphatase" /protein_id="NP_391291.1" /db_xref="EnsemblGenomes-Gn:BSU34110" /db_xref="EnsemblGenomes-Tr:CAB15416" /db_xref="GOA:O07014" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG12441" /db_xref="UniProtKB/Swiss-Prot:O07014" /translation="MDKQLNDAPCGFLALSEEGSIIAANRTLIKILDYEPEQVIGQHM NMMLTIPAQLFCQLYFFPLLKLEHHIEEIYISLKARDGEEIPVLINAIARHDSGASVF DCVLIPMRKRNEYENELLIARNEAQEALLAKQKANAELEIALETLKAKQEELLEINKQ NQQFKLNTKRELELARKIQKNSLTEPIVNDQVQIDSYYNASSELSGDLYGYYQIDEHR YGIIILDVMGHGISSALITMSLHPLFQRQITQGLSPVKVMKELDRHLHSLFQNDEEAR HYCTAIYLEIDIARQRIDYVNAGHPPALWQDDSGTQHLLHATSPPIGMFEDLEFQSSS LSYTEDGRLLLYTDGVMDPTASCYLFDLLKDHPDSPIADLKEKILTSLQHQKEAHHKS DDECFILVDVK*" /label="rsbP CDS" gene 2930614..2931825 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /label="rsbP gene" downshifts 2931812 /Source="Nicolas_upshifts" /id="D1774" /incds=0 /nref=181 /ntot=246 /MaxReadThrough="0.90827" /MaxDrop="5.41923" /score="26.3528321" /energy="-17.8" /TU="NA" /idTUdmin="U2692" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2931879..2933168) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11682178, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,4-galactanase" /protein_id="NP_391292.2" /db_xref="EnsemblGenomes-Gn:BSU34120" /db_xref="EnsemblGenomes-Tr:CAB15417" /db_xref="GOA:O07013" /db_xref="InterPro:IPR011683" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12440" /db_xref="UniProtKB/Swiss-Prot:O07013" /translation="MKSKVKMFFAAAIVWSACSSTGYAAAIEKEKHVSELRAEDLFVK KVEGMNKDFIKGADVSSVIALENSGVTFYNTNGKRQDIFTTLKQAGVNYVRVRIWNHP YDSNGNGYGGGNNDVQKAIEIGKRATANGMKVLADFHYSDFWADPAKQKVPKAWANLS FEAKKAKLYEYTKQSLQKMIKEGVDIGMVQVGNETTGGFAGETDWTKMCQLFNEGSRA VRETNSNILVALHFTNPETAGRYSFIAETLSKNKVDYDVFASSYYPFWHGTLQNLTSV LKAVANTYGKKVMVAETSYTYTAEDGDGHGNTAPKSGQTLPYPISVQGQATAVRDVME AVANTGKAGLGVFYWEPAWIPVGPKTQIEKNKVLWETYGSGWASSYAAEYDPEDAGKW YGGSAVDNQALFDFNGHPLPSLQVFQYAESGHIPKKR*" /label="ganB CDS" gene complement(2931879..2933168) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /label="ganB gene" CDS complement(2933248..2935311) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /EC_number="3.2.1.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="short chain beta-1,4-galacto-oligosaccharides beta-galactosidase (beta-galacto-pyranoside hydrolase)" /protein_id="NP_391293.1" /db_xref="EnsemblGenomes-Gn:BSU34130" /db_xref="EnsemblGenomes-Tr:CAB15418" /db_xref="GOA:O07012" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12439" /db_xref="UniProtKB/Swiss-Prot:O07012" /translation="MMSKLEKTHVTKAKFMLHGGDYNPDQWLDRPDILADDIKLMKLS HTNTFSVGIFAWSALEPEEGVYQFEWLDDIFERIHSIGGRVILATPSGARPAWLSQTY PEVLRVNASRVKQLHGGRHNHCLTSKVYREKTRHINRLLAERYGHHPALLMWHISNEY GGDCHCDLCQHAFREWLKSKYDNSLKTLNHAWWTPFWSHTFNDWSQIESPSPIGENGL HGLNLDWRRFVTDQTISFYENEIIPLKELTPDIPITTNFMADTPDLIPYQGLDYSKFA KHVDAISWDAYPVWHNDWESTADLAMKVGFINDLYRSLKQQPFLLMECTPSAVNWHNV NKAKRPGMNLLSSMQMIAHGSDSVLYFQYRKSRGSSEKLHGAVVDHDNSPKNRVFQEV AKVGETLERLSEVVGTKRPAQTAILYDWENHWALEDAQGFAKATKRYPQTLQQHYRTF WEHDIPVDVITKEQDFSPYKLLIVPMLYLISEDTVSRLKAFTADGGTLVMTYISGVVN EHDLTYTGGWHPDLQAIFGVEPLETDTLYPKDRNAVSYRSQIYEMKDYATVIDVKTAS VEAVYQEDFYARTPAVTSHEYQQGKAYFIGARLEDQFQRDFYEGLITDLSLSPVFPVR HGKGVSVQARQDQDNDYIFVMNFTEEKQLVTFDQSVKDIMTGDILSGDLTMEKYEVRI VVNTH*" /label="ganA CDS" gene complement(2933248..2935311) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /label="ganA gene" CDS complement(2935330..2936181) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17056685, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391294.1" /db_xref="EnsemblGenomes-Gn:BSU34140" /db_xref="EnsemblGenomes-Tr:CAB15419" /db_xref="GOA:O07011" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12438" /db_xref="UniProtKB/Swiss-Prot:O07011" /translation="MLADMKVRRYIRLLFSYLLLAFMAVIIVYPLLWTAGASFNPGNS LISTSIIPKHPTFDHYKELFAGKESLQYVQWYVNSMKISLFTMAGSLLCVTFTAYAFS RFRFKGRKYALTLFLLLQMIPQFSALIALFVLAQILGMINSHWLLILLYIGGLIPMNT YLMKGYMDSIPMDLDESAKIDGASSTRIFFQIILPLSKPMAAVVAMNGFTGPLGDFVL SSTILRTPESYTLPVGLFNLVNDVMGASYTTFAAGALLISIPVAVIFIMLQKNFVSGL TAGGTKG*" /label="ganQ CDS" gene complement(2935330..2936181) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /label="ganQ gene" CDS complement(2936185..2937441) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11160890, 15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 15849754, 16850406, 17056685, 27501980; Product type t : transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391295.1" /db_xref="EnsemblGenomes-Gn:BSU34150" /db_xref="EnsemblGenomes-Tr:CAB15420" /db_xref="GOA:O32261" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12437" /db_xref="UniProtKB/Swiss-Prot:O32261" /translation="MQHRQVALLLSIIPGLGQFYNKQWIKGIVFLFLGASFFAVFGDL LNMGFWGIFTLGTEVPRDNSVFLLAEGIIAVIVTCFGLAVYYVNLRDAFQSGKQRDEN KPLSSLKEQYQHIISEGYPYVVSGPSLFILIFAVIFPILFSFALAFTNYDLYHSPPAK LIDWVGFQTFANIFTVDIWRSTFFDVLAWTVVWTLAASTLQVTLGIFLAIIVNQKDLR FKRFFRTILILPWAVPGFVTILIFAGLFNDSFGAMNHDILAFFGIDPLPWMTDANWSR LALILMQGWLGFPYIFLVSTGVLQSIPDDLYEAATIDGASVFSKLRYITLPMVFIAMA PIIITQFTFNFNNFNIIYLFNGGGPAVTGSTAGGTDILVSWIYKLTMQSSQYSLAAAL TILLSVFVISIALWQFRQTKSFKEEA*" /label="ganP CDS" gene complement(2936185..2937441) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /label="ganP gene" CDS complement(2937481..2938746) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11682178, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="polygalactose / cyclodextrin-binding lipoprotein" /protein_id="NP_391296.1" /db_xref="EnsemblGenomes-Gn:BSU34160" /db_xref="EnsemblGenomes-Tr:CAB15421" /db_xref="GOA:O07009" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12436" /db_xref="UniProtKB/Swiss-Prot:O07009" /translation="MKMAKKCSVFMLCAAVSLSLAACGPKESSSAKSSSKGSELVVWE DKEKSNGIKDAVAAFEKEHDVKVKVVEKPYAKQIEDLRMDGPAGTGPDVLTMPGDQIG TAVTEGLLKELHVKKDVQSLYTDASIQSQMVDQKLYGLPKAVETTVLFYNKDLITEKE LPKTLEEWYDYSKKTADGSKFGFLALFDQIYYAESVMSGYGGYIFGKAKDGSYNPSDI GINNEGAVKGAALIQKFYKDGLFPAGIIGEQGINVLESLFTEGKAAAIISGPWNVEAF SNAGINYGITKLPKLENGKNMSSFIGVKSYNVSAFSKNEELAQELAVFLANEKNSKTR YEETKEVPAVKSLANDPAIMKSEAARAVTEQSRFSEPTPNIPEMNEIWTPADSALQTV ATGKADPKQALDQAAETAKGQIKAKHSGK*" /label="ganS CDS" gene complement(2937481..2938746) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /label="ganS gene" promotor_-10 complement(2938778..2938797) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2938800) /Source="Nicolas_upshifts" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2938812..2938819) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2938887..2939879) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 10486575, 17056685, 27501980, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 10486575, 17056685, 27501980, 28617843; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the galactan degradation operon (GanR / beta-1,4-galactobiose)" /protein_id="NP_391297.1" /db_xref="EnsemblGenomes-Gn:BSU34170" /db_xref="EnsemblGenomes-Tr:CAB15422" /db_xref="GOA:O07008" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12435" /db_xref="UniProtKB/Swiss-Prot:O07008" /translation="MATIKDIAQEAGFSISTVSRVLNNDESLSVPDETREKIYEAAEK LNYRKKTVRPLVKHIAFLYWLTDKEELEDVYFKTMRLEVEKLAKAFNVDMTTYKIADG IESIPEHTEGFIAVGTFSDEELAFLRNLTENGVFIDSTPDPDHFDSVRPDLAQMTRKT VNILTEKGHKSIGFIGGTYKNPNTNQDEMDIREQTFRSYMREKAMLDERYIFCHRGFS VENGYRLMSAAIDTLGDQLPTAFMIAADPIAVGCLQALNEKGIAIPNRVSIVSINNIS FAKYVSPPLTTFHIDIHELCKNAVQLLLEQVQDKRRTVKTLYVGAELIVRKSMN*" /label="ganR CDS" gene complement(2938887..2939879) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /label="ganR gene" downshifts complement(2938921) /Source="Nicolas_upshifts" /id="D1775" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="1.40325" /MaxDrop="2.80992" /score="14.7399792" /energy="-8.3" /TU="NA" /idTUdmin="U2694" /TUdmin=1111 /isTUend="FALSE" /label="downshifts" S_feature complement(2940009..2940058) /Source="Nicolas_S_feature" /locus_tag="new_3509781_3509830_c" /HighExp="Sw, BC, M0t90, M40t90, B60, Lbstat, Lbtran, S2, B36, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29208099999999998" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1307" downshifts complement(2940032) /Source="Nicolas_upshifts" /id="D1776" /incds=0 /nref=88 /ntot=240 /MaxReadThrough="1.88481" /MaxDrop="5.0699" /score="7.28170345" /energy="-13.7" /TU="NA" /idTUdmin="U2694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2940059..2940718) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18604637, 24196425, 25031425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18604637, 24196425, 25031425; Product type r: regulator" /codon_start=1 /transl_table=11 /product="L-lactate utilization global transcriptional regulator (GntR family)" /protein_id="NP_391298.2" /db_xref="EnsemblGenomes-Gn:BSU34180" /db_xref="EnsemblGenomes-Tr:CAB15423" /db_xref="GOA:O07007" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12434" /db_xref="UniProtKB/Swiss-Prot:O07007" /translation="MIKNGELKPGDKLDSVQALAESFQVSRSAVREALSALKAMGLVE MKQGEGTYLKEFELNQISQPLSAALLMKKEDVKQLLEVRKLLEIGVASLAAEKRTEAD LERIQDALKEMGSIEADGELGEKADFAFHLALADASQNELLKHLMNHVSSLLLETMRE TRKIWLFSKKTSVQRLYEEHERIYNAVAAGNGAQAEAAMLAHLTNVEDVLSGYFEENV Q*" /label="lutR CDS" gene complement(2940059..2940718) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /label="lutR gene" S_feature complement(2940719..2940824) /Source="Nicolas_S_feature" /locus_tag="new_3510491_3510596_c" /HighExp="M0t90, Lbstat, BC, M40t90, Lbtran, Sw, S2, B60, ferm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69672000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1308" promotor_-10 complement(2940816..2940835) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2940825) /Source="Nicolas_upshifts" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2940850..2940853) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2940877..2940884 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2940899..2940918 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2940899 /Source="Nicolas_upshifts" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="upshifts" S_feature 2940902..2941007 /Source="Nicolas_S_feature" /locus_tag="new_3510674_3510779" /HighExp="T1.30H, S1, T1.0H, M40t90, T2.0H, M0t90, T3.0H, T2.30H, T0.30H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1309" promotor_-10 complement(2940908..2940925) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2940912) /Source="Nicolas_upshifts" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2940933..2940939) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2941008..2942699 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25031425; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_391299.1" /db_xref="EnsemblGenomes-Gn:BSU34190" /db_xref="EnsemblGenomes-Tr:CAB15424" /db_xref="GOA:P71067" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG11875" /db_xref="UniProtKB/Swiss-Prot:P71067" /translation="MQWTQAYTPIGGNLLLSALAALVPIIFFFWALAIKRMKGYTAGL ATLGIALIIAVLVYRMPAEKALMSATQGAVYGLLPIGWIIVTSVFLYKITVKTGQFDI IRSSVLSITDDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLVGLGFNPLYAAGIC LIANTAPVAFGAIGIPITAVEGPTGIPAMEISQMVGRQLPFLSVFIPLYLIIIMSGFR KALEIWPAILVSGVSFAVVQYLSSNFLGPELPDVLSALVSMAALAVFLKWWKPKTTFR FAGEQESAASIETARTNPAAPAYRGGQIFKAWSPFLLLTAMISVWGIPSVKSALTGHY EGSAVFLKWLNAVGEKLTFSPGVPFLNNQIVNADGTPIEAVYKLEVLGSAGTAILIAA VLSKFITAISWKDWGTVFKETVQELKLPILTIASVVGFAYVTNSSGMSTTLGMTLALT GSMFTFFSPVLGWLGVFITGSDTSANLLFGNLQKVTALSVGMDPVLSVAANSSGGVTG KMISPQSIAVACAAVGLAGKESDLFRFTIKHSLFLLLLVCIITFLQHHVFSWMIP*" /label="lutP CDS" gene 2941008..2942699 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /label="lutP gene" downshifts 2942684 /Source="Nicolas_upshifts" /id="D1777" /incds=0 /nref=153 /ntot=245 /MaxReadThrough="4.82757" /MaxDrop="5.44233" /score="20.8815301" /energy="-11.7" /TU="NA" /idTUdmin="U2695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2942726..2944036) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11274109, 12533460, 12634342, 16166551, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 12533460, 12634342, 16166551, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-54 factor (sigma-L)" /protein_id="NP_391300.1" /db_xref="EnsemblGenomes-Gn:BSU34200" /db_xref="EnsemblGenomes-Tr:CAB15425" /db_xref="GOA:P24219" /db_xref="InterPro:IPR000394" /db_xref="InterPro:IPR007046" /db_xref="InterPro:IPR007634" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10748" /db_xref="UniProtKB/Swiss-Prot:P24219" /translation="MDMKLQQVQVLKPQLTQELRQAITLLGYHSAELAEYIDELSLEN PLIERKETDTPPLSYHKTNKNRMNAQEAGLQLSNPQKTLQDALKQQSLDMNLTNTEKK IFNYLIHSLDSNGYLEEDIEEAARRLSVSAKEAEAVLAKLQSLEPAGIGARSLQECIL LQLQRLPNRNEQAEMLVSAHFDAFAQKKWKTLSVETGIPLHTIQDISDDIAALHPRPG LLFARPEQDVYIEPDIFITVKNGHIAAELNTRSFPEIDLHPQYRTLLSSGSCQDTVSY LSAKYQEWRWLSRALRQRKQTITRIINELITRQKDFFLKGRSAMKPLTLREVADCLSL HESTVSRAIKGKTIQTPYGLFEMKLFFSAKAEASGDGDASNYAVKTHLENLINQEDKT KPLSDQKLVDLLYEQHGIQISRRTVAKYRDQMNIPSSAARKRYK*" /label="sigL CDS" gene complement(2942726..2944036) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /label="sigL gene" S_feature 2942729..2943799 /Source="Nicolas_S_feature" /locus_tag="new_3512501_3513571" /HighExp="M9-stat, T1.30H, S1, Sw, T1.0H, T2.0H, T0.30H, G/S, T3.30H, T2.30H" /AntisenseName="sigL" /AntisenseCor="0.63927172079726402" /AntisenseRegPval="-31.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1310" downshifts complement(2942738) /Source="Nicolas_upshifts" /id="D1778" /incds=0 /nref=62 /ntot=219 /MaxReadThrough="2.33779" /MaxDrop="5.56948" /score="28.2409666" /energy="-11.7" /TU="NA" /idTUdmin="U2698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2943856..2943875 /Source="Nicolas_upshift_promotors" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2943856..2944114 /Source="Nicolas_S_feature" /locus_tag="new_3513628_3513886" /HighExp="LBGstat, LBGexp, G180, Paraq, H2O2, LBGtran, Oxctl, Lbexp, dia0, HPh" /AntisenseName="sigL" /AntisenseCor="-0.50245218771496702" /AntisenseRegPval="-17.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1311" upshifts 2943856 /Source="Nicolas_upshifts" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2944050..2944069) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2944065) /Source="Nicolas_upshifts" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2944084..2944087) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2944115..2944333 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391301.1" /db_xref="EnsemblGenomes-Gn:BSU34210" /db_xref="EnsemblGenomes-Tr:CAB15426" /db_xref="InterPro:IPR018590" /db_xref="PDB:2GSV" /db_xref="PDB:2JS1" /db_xref="SubtiList:BG11876" /db_xref="UniProtKB/Swiss-Prot:P71066" /translation="MSELFSVPYFIENLKQHIEMNQSEDKIHAMNSYYRSVVSTLVQD QLTKNAVVLKRIQHLDEAYNKVKRGESK*" /label="yvfG CDS" gene 2944115..2944333 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /label="yvfG gene" downshifts 2944312 /Source="Nicolas_upshifts" /id="D1779" /incds=0 /nref=53 /ntot=250 /MaxReadThrough="3.27525" /MaxDrop="4.21929" /score="-0.306638574" /energy="-13.4" /TU="U2697" /idTUdmin="U2697" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" SCAR join(2944340,2944347) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs26" N_region 2944341..2944346 /note="EcoR site (GAATTC)" /created_by="User" /modified_by="User" /label="IIG_Bs26" promotor_-35 2944378..2944381 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2944387 /Source="Nicolas_upshifts" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2944398..2944416 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2944432..2945901 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7828905, 15138843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7828905, 15138843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="para-nitrobenzyl esterase (intracellular esterase B)" /protein_id="NP_391319.1" /db_xref="EnsemblGenomes-Gn:BSU34390" /db_xref="EnsemblGenomes-Tr:CAB15444" /db_xref="GOA:P37967" /db_xref="InterPro:IPR000997" /db_xref="InterPro:IPR002018" /db_xref="InterPro:IPR019819" /db_xref="InterPro:IPR019826" /db_xref="InterPro:IPR029058" /db_xref="PDB:1C7I" /db_xref="PDB:1C7J" /db_xref="PDB:1QE3" /db_xref="SubtiList:BG11844" /db_xref="UniProtKB/Swiss-Prot:P37967" /translation="MTHQIVTTQYGKVKGTTENGVHKWKGIPYAKPPVGQWRFKAPEP PEVWEDVLDATAYGSICPQPSDLLSLSYTELPRQSEDCLYVNVFAPDTPSKNLPVMVW IHGGAFYLGAGSEPLYDGSKLAAQGEVIVVTLNYRLGPFGFLHLSSFNEAYSDNLGLL DQAAALKWVRENISAFGGDPDNVTVFGESAGGMSIAALLAMPAAKGLFQKAIMESGAS RTMTKEQAASTSAAFLQVLGINEGQLDKLHTVSAEDLLKAADQLRIAEKENIFQLFFQ PALDPKTLPEEPEKAIAEGAASGIPLLIGTTRDEGYLFFTPDSDVHSQETLDAALEYL LGKPLAEKVADLYPRSLESQIHMMTDLLFWRPAVAYASAQSHYAPVWMYRFDWHPKKP PYNKAFHALELPFVFGNLDGLERMAKAEITDEVKQLSHTIQSAWITFAKTGNPSTEAV NWPAYHEETRETLILDSEITIENDPESEKRQKLFPSKGE*" /label="pnbA CDS" gene 2944432..2945901 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /label="pnbA gene" downshifts 2945878 /Source="Nicolas_upshifts" /id="D1780" /incds=0 /nref=4 /ntot=150 /MaxReadThrough="3.66738" /MaxDrop="2.70933" /score="-9.70074934" /energy="-12.2" /TU="U2703" /idTUdmin="U2703" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS 2945904..2946095 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514003.1" /translation="MGKTGYIGAAIVVAACIIILSAVVCLRDTVYYQPMRWTGIILFF AGIVMVPAYSAKRKPGKEK*" /label="hypothetical protein CDS" gene 2945904..2946095 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /label="gene" downshifts 2946074 /Source="Nicolas_upshifts" /id="D1781" /incds=0 /nref=24 /ntot=181 /MaxReadThrough="-0.096" /MaxDrop="4.20686" /score="34.8993337" /energy="-22.3" /TU="NA" /idTUdmin="U2703" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2946122..2946607) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /EC_number="4.1.1.102" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9546183, 12903944, 17295427, 18326577, 21685295, 26658822" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9546183, 12903944, 17295427, 18326577, 21685295, 26658822; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase" /protein_id="NP_391320.1" /db_xref="EnsemblGenomes-Gn:BSU34400" /db_xref="EnsemblGenomes-Tr:CAB15445" /db_xref="GOA:O07006" /db_xref="InterPro:IPR008729" /db_xref="InterPro:IPR012674" /db_xref="PDB:2P8G" /db_xref="PDB:4ALB" /db_xref="SubtiList:BG12433" /db_xref="UniProtKB/Swiss-Prot:O07006" /translation="MENFIGSHMIYTYENGWEYEIYIKNDHTIDYRIHSGMVAGRWVR DQEVNIVKLTEGVYKVSWTEPTGTDVSLNFMPNEKRMHGIIFFPKWVHEHPEITVCYQ NDHIDLMKESREKYETYPKYVVPEFAEITFLKNEGVDNEEVISKAPYEGMTDDIRAGR L*" /label="padC CDS" gene complement(2946122..2946607) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /label="padC gene" CDS complement(2946630..2946941) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="EnsemblGenomes-Gn:BSU34410" /db_xref="EnsemblGenomes-Tr:CAB15446" /db_xref="GOA:O07005" /db_xref="InterPro:IPR011250" /db_xref="InterPro:IPR020915" /db_xref="PSEUDO:CAB15446.2" /db_xref="SubtiList:BG12432" /db_xref="UniProtKB/Swiss-Prot:O07005" /translation="MPGGADSQMIRANGRTDLSARYVIETADHELIYIENNGIRQVSK PFRKQAAAGEIIEPEHVYFRTVPTFETGSEVYQWLHDRLFIGSAERTPDYVLLDIYEV Q*" /label="yveG CDS" gene complement(2946630..2946941) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /pseudo /label="yveG gene" CDS complement(2946993..2947085) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU34420" /db_xref="EnsemblGenomes-Tr:CAB15447" /db_xref="PSEUDO:CAB15447.1" /db_xref="SubtiList:BG12431" /db_xref="UniProtKB/Swiss-Prot:O07004" /translation="MKKPVLKPFASLEIKVDPPITIGETSLGLR*" /label="yveF CDS" gene complement(2946993..2947085) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /pseudo /label="yveF gene" promotor_-10 complement(2947125..2947144) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2947142) /Source="Nicolas_upshifts" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2947158..2947165) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2947216..2947899) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /EC_number="5.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9987136, 19063962, 2054383, 28894939" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 19063962, 2054383, 28894939; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aminoacid racemase (prefers arginine, lysine and ornithine)" /protein_id="NP_391323.1" /db_xref="EnsemblGenomes-Gn:BSU34430" /db_xref="EnsemblGenomes-Tr:CAB15448" /db_xref="GOA:P32960" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004380" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="SubtiList:BG10391" /db_xref="UniProtKB/Swiss-Prot:P32960" /translation="MIGILAGMGPKSTSPFIDKVIDYCQKLYGASNDIDYPHMMIYSC PTPFYADRPIDHDEMKKAIIDGAVKLEKTGVDFIALPCNTAHVYYEEIQQALSVPMLH IVEETIKEIPHPAKKAVVLGTEPTIQSAIYQKVLKGNGQEVIHKDHWQQAVNQLIAAI KQPNHMQHTQALWQTLYEEISQHADIIISACTDLNAVLDHIQSEIPIIDSSACLAKST VSTYLAYQS*" /label="racX CDS" gene complement(2947216..2947899) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /label="racX gene" downshifts complement(2947234) /Source="Nicolas_upshifts" /id="D1782" /incds=0 /nref=122 /ntot=223 /MaxReadThrough="3.49026" /MaxDrop="5.32077" /score="5.15607483" /energy="-9.3" /TU="U2705" /idTUdmin="U2704" /TUdmin="-708" /isTUend="FALSE" /label="downshifts" CDS complement(2947915..2949270) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7592498, 9987136, 12533473, 14679248, 19063962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592498, 9987136, 12533473, 14679248, 19063962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4*" /protein_id="NP_391324.1" /db_xref="EnsemblGenomes-Gn:BSU34440" /db_xref="EnsemblGenomes-Tr:CAB15449" /db_xref="GOA:P32959" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR021860" /db_xref="SubtiList:BG10390" /db_xref="UniProtKB/Swiss-Prot:P32959" /translation="MKQNKRKHLQTLFETLGEKHQFNGTVLAAEGGDILYHHSFGYAE MTEKRPLKTNSLFELASLSKPFTALGIILLEEKGILGYEDKVDRWLPGFPYQGVTIRH LLNHTSGLPDYMGWFFANWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVL LAVIIEKASGMSYADFIKTSIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETY VLPDELEETNYVVYLDGIQGDGTVNSVTSDLFRFDQALYQDDFISKASKESAFSPVRL NNGETIDYGFGWVLQNSPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTE YEQAILKAAEHILFGQPYDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAAQVTTEN ERLYLEIAGQLRLELFPSSETRFFLRALSVEVEFTLGEDAAKSFILYEDGSEEEAVRT K*" /label="pbpE CDS" gene complement(2947915..2949270) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /label="pbpE gene" promotor_-10 complement(2949282..2949297) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2949298) /Source="Nicolas_upshifts" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2949309..2949318) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2949572..2949579 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2949593..2949612 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2949596 /Source="Nicolas_upshifts" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="upshifts" S_feature 2949618..2949808 /Source="Nicolas_S_feature" /locus_tag="new_3535821_3536011" /HighExp="G150, G180, G135, LBGexp, Mt0, Lbexp, LBGtran, dia0, GM 150, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.219024" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1314" CDS 2949809..2951230 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /EC_number="2.4.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levansucrase; levanase (moonlighting)" /protein_id="NP_391325.1" /db_xref="EnsemblGenomes-Gn:BSU34450" /db_xref="EnsemblGenomes-Tr:CAB15450" /db_xref="GOA:P05655" /db_xref="InterPro:IPR003469" /db_xref="InterPro:IPR023296" /db_xref="PDB:1OYG" /db_xref="PDB:1PT2" /db_xref="PDB:2VDT" /db_xref="PDB:3BYJ" /db_xref="PDB:3BYK" /db_xref="PDB:3BYL" /db_xref="PDB:3BYN" /db_xref="SubtiList:BG10388" /db_xref="UniProtKB/Swiss-Prot:P05655" /translation="MNIKKFAKQATVLTFTTALLAGGATQAFAKETNQKPYKETYGIS HITRHDMLQIPEQQKNEKYQVPEFDSSTIKNISSAKGLDVWDSWPLQNADGTVANYHG YHIVFALAGDPKNADDTSIYMFYQKVGETSIDSWKNAGRVFKDSDKFDANDSILKDQT QEWSGSATFTSDGKIRLFYTDFSGKHYGKQTLTTAQVNVSASDSSLNINGVEDYKSIF DGDGKTYQNVQQFIDEGNYSSGDNHTLRDPHYVEDKGHKYLVFEANTGTEDGYQGEES LFNKAYYGKSTSFFRQESQKLLQSDKKRTAELANGALGMIELNDDYTLKKVMKPLIAS NTVTDEIERANVFKMNGKWYLFTDSRGSKMTIDGITSNDIYMLGYVSNSLTGPYKPLN KTGLVLKMDLDPNDVTFTYSHFAVPQAKGNNVVITSYMTNRGFYADKQSTFAPSFLLN IKGKKTSVVKDSILEQGQLTVNK*" /label="sacB CDS" gene 2949809..2951230 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /label="sacB gene" downshifts 2951224 /Source="Nicolas_upshifts" /id="D1783" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.33324" /MaxDrop="3.39023" /score="9.57663013" /energy="-7.7" /TU="NA" /idTUdmin="U2706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 2951304..2952854 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /EC_number="3.2.1.64" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11739774, 15528654, 26773563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11739774, 15528654, 26773563; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endolevanase, selectively cleaves the (beta-2,6)fructosyl bonds" /protein_id="NP_391326.1" /db_xref="EnsemblGenomes-Gn:BSU34460" /db_xref="EnsemblGenomes-Tr:CAB15451" /db_xref="GOA:O07003" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG12430" /db_xref="UniProtKB/Swiss-Prot:O07003" /translation="MNYIKAGKWLTVFLTFLGILLFIDLFPKEEHDQKTKSKQKPDYR AAYHFTTPDKWKNDPQKPIYFDGKYHYFYLYNRDYPKGNGTEWRHAVSEDLVHWTDEG VAIPKYTNPDGDIWTGSVVVDKENTAGFGKNALVAIVTQPSAKDKKQEQYLWYSTDKG KSFKFYSGNPVMPNPGTDDFRDPKVIWDDQDNKWVMVMAEGSKIGFYESDNLKDWHYT SGFFPEQAGMVECPDLYMMRASDGTNKWVLGASANGKPWGKPNTYAYWTGSFDGKEFK ADQTEAQWLDYGFDWYGGVTFEDSKSTDPLEKRYALAWMNNWDYANNTPTMKNGFNGT DSVIRELRLKEQDGTYSLVSQPIEALEQLTVSTDEIEDQDVNGSKTLSITGDTYQLDT DLSWSELKNAGVRLRESEDQKRHIDVGIFAEGGYAYVNRAATNQPDKSNTYVESKAPY DVNKRKVHLKILVDKTTIEVFVGDGKTVFSNEVFPKPEDKGITLYSDGGTASFKNITV KHFDSIHE*" /label="levB CDS" gene 2951304..2952854 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /label="levB gene" promotor_-35 2952898..2952904 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2952918..2952929 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2952918 /Source="Nicolas_upshifts" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="upshifts" CDS 2952962..2954524 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12730183, 15528654, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12730183, 15528654, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-aspartate/L-glutamate / proton permease" /protein_id="NP_391327.1" /db_xref="EnsemblGenomes-Gn:BSU34470" /db_xref="EnsemblGenomes-Tr:CAB15452" /db_xref="GOA:O07002" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12429" /db_xref="UniProtKB/Swiss-Prot:O07002" /translation="MSKQGNFQKSMSLFDLILIGMGAIFGSAWLFAVSNVASKAGPSG AFSWILGGAIILLIGLVYAELGAALPRTGGIIRYPVYSHGHLVGYLISFVTIVAYTSL ISIEVTAVRQYVAYWFPGLTIKGSDSPTISGWILQFALLCLFFLLNYWSVKTFAKANF IISIFKYIVPITIIIVLIFHFQPENLSVQGFAPFGFTGIQAAISTGGVMFAYLGLHPI VSVAGEVQNPKRNIPIALIICIIVSTIIYTVLQVTFIGAIPTETLKHGWPAIGREFSL PFKDIAVMLGLGWLATLVILDAILSPGGNGNIFMNTTSRLVYAWARNGTLFGIFSKVN KDTGTPRASLWLSFALSIFWTLPFPSWNALVNVCSVALILSYAIAPISSAALRVNAKD LNRPFYLKGMSIIGPLSFIFTAFIVYWSGWKTVSWLLGSQLVMFLIYLCFSKYTPKED VSLAQQLKSAWWLIGFYIMMLIFSYIGSFGHGLGIISNPVDLILVAIGSLAIYYWAKY TGLPKAAIDYDK*" /label="aspP CDS" gene 2952962..2954524 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /label="aspP gene" downshifts 2954502 /Source="Nicolas_upshifts" /id="D1784" /incds=0 /nref=12 /ntot=29 /MaxReadThrough="1.71122" /MaxDrop="3.47798" /score="-0.444529447" /energy="-11.7" /TU="NA" /idTUdmin="U2707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 2954514..2955203 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391328.2" /db_xref="EnsemblGenomes-Gn:BSU34480" /db_xref="EnsemblGenomes-Tr:CAB15453" /db_xref="GOA:O07001" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:2F07" /db_xref="SubtiList:BG12428" /db_xref="UniProtKB/Swiss-Prot:O07001" /translation="MINKEARGFLASLFFTNKHTRDKMNESQSLLEVFLMPKQTSGKY EKILQAAIEVISEKGLDKASISDIVKKAGTAQGTFYLYFSSKNALIPAIAENLLTHTL DQIKGRLHGDEDFWTVLDILIDETFLITERHKDIIVLCYSGLAIDHSMEKWETIYQPY YSWLEKIINKAIANHEVTEGINSKWTARTIINLVENTAERFYIGFEQDENVEVYKKEI FTFLKRSLGTA*" /label="yvdT CDS" gene 2954514..2955203 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /label="yvdT gene" promotor_-35 2954553..2954560 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2954574..2954593 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2954583 /Source="Nicolas_upshifts" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="upshifts" downshifts 2955184 /Source="Nicolas_upshifts" /id="D1785" /incds=0 /nref=189 /ntot=242 /MaxReadThrough="4.85194" /MaxDrop="4.84113" /score="-0.444529447" /energy="-11.7" /TU="U2708" /idTUdmin="U2707" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(2955282) /Source="Nicolas_upshifts" /id="D1786" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="0.8852" /MaxDrop="3.45447" /score="0.398849185" /energy="-11.7" /TU="NA" /idTUdmin="U2709" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS 2955285..2955620 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22978536; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium / proton antiporter subunit A" /protein_id="NP_391329.1" /db_xref="EnsemblGenomes-Gn:BSU34490" /db_xref="EnsemblGenomes-Tr:CAB15454" /db_xref="GOA:O32262" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12427" /db_xref="UniProtKB/Swiss-Prot:O32262" /translation="MNWVLVFIAGLLEVVWASSLKHADSLLDWIIIFILIAVSFILLI RSYQKIPMAAAYTVFVGIGTVGTYLTGIVLGESFSAAQMFFLALLLAGILGMKLFTKE SKSQPGGEK*" /label="psmA CDS" gene 2955285..2955620 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /label="psmA gene" CDS 2955620..2955940 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11160890, 22978536; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium-proton two component antiporter subunit" /protein_id="NP_391330.1" /db_xref="EnsemblGenomes-Gn:BSU34500" /db_xref="EnsemblGenomes-Tr:CAB15455" /db_xref="GOA:O06999" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12426" /db_xref="UniProtKB/Swiss-Prot:O06999" /translation="MAWFLLVIAGIEEIIAAIAMKYIDGTRKKWPIIVMTVGFGLSFY CLSQAMIVLPAGVAYAVWTGIGSIGVSAVGLIWFKERFQLSQVISLCLILAGVIGLRL TSSS*" /label="psmB CDS" gene 2955620..2955940 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /label="psmB gene" S_feature 2955941..2956131 /Source="Nicolas_S_feature" /locus_tag="new_3542144_3542334" /HighExp="Sw, BC, BI, Lbstat, M0t90, Lbtran, M40t90, H2O2, S8, Paraq" /AntisenseName="yvdQ" /AntisenseCor="3.5547360410813897E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1315" CDS complement(2955976..2956488) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391331.1" /db_xref="EnsemblGenomes-Gn:BSU34510" /db_xref="EnsemblGenomes-Tr:CAB15456" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR021617" /db_xref="SubtiList:BG12425" /db_xref="UniProtKB/Swiss-Prot:O06998" /translation="MGILSGNPQDEPMHYGEVFGLWSYVMAGNKMVGNYQMLLNHVGD DDLKKLLRESIEKCQDEIKQVSTILKENGVALPPASPEPPTADLNDIPPGARFLDPDV AASAAAENAAGLVTCSKMMGQSIREDIAMMFGQFHMSKAATGAKYLRLLKNKGWLIPP PLHLQKHHEA*" /label="yvdQ CDS" gene complement(2955976..2956488) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /label="yvdQ gene" downshifts 2956108 /Source="Nicolas_upshifts" /id="D1787" /incds=1 /nref=6 /ntot=39 /MaxReadThrough="1.61612" /MaxDrop="4.65362" /score="0.608596632" /energy="-14.2" /TU="NA" /idTUdmin="U2708" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2956524..2956535) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2956530) /Source="Nicolas_upshifts" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2956550..2956556) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2956603..2956739) /Source="Nicolas_S_feature" /locus_tag="new_3542806_3542942_c" /HighExp="BT, S7, S8, S6, B36, G/S, S5, Pyr, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1316" downshifts complement(2956646) /Source="Nicolas_upshifts" /id="D1788" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.38169" /MaxDrop="2.9968" /score="15.2862513" /energy="-10.3" /TU="U2710" /idTUdmin="U2709" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" CDS complement(2956740..2958083) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /EC_number="1.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat protein; putative oxidoreductase" /protein_id="NP_391332.1" /db_xref="EnsemblGenomes-Gn:BSU34520" /db_xref="EnsemblGenomes-Tr:CAB15457" /db_xref="GOA:O06997" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12424" /db_xref="UniProtKB/Swiss-Prot:O06997" /translation="MGSTQLTGRVIFKGDPGYTEAIKNWNPYVDVYPLVFVFAQNSYD VSNAIKWARENKVPLRVRSGRHALDKNLSVVSGGIVIDVSDMNKVFLDEENAIATVQT GIPVGPLVKGLARDGFMAPFGDSPTVGIGGITMGGGFGVLSRSIGLISDNLLALKTVD AKGRIIHADQSHNEDLLWASRGGGGGNFGYNTQYTFKVHRAPKTATVFNIIWPWEQLE TVFKAWQKWAPFVDERLGCYLEIYSKINGLCHAEGIFLGSKTELIRLLKPLLHAGTPT EADIKTLYYPDAIDFLDPDEPIPGRNDQSVKFSSAWGHDFWSDEPISIMRKFLEDATG TEANFFFINWGGAISRVPKDETAFFWRHPLFYTEWTASWKNKSQEDSNLASVERVRQL MQPYVAGSYVNVPDQNIENFGKEYYGANFARLREIKAKYDPENVFRFPQSIPPSR*" /label="cotNP CDS" gene complement(2956740..2958083) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /label="cotNP gene" promotor_-10 complement(2958112..2958131) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2958120) /Source="Nicolas_upshifts" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2958144..2958153) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2958145..2958150 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2958166..2958184 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2958169 /Source="Nicolas_upshifts" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2958378..2958387 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2958396 /Source="Nicolas_upshifts" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2958401..2958420 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2958439..2959401 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 20378985" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 20378985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat lipolytic enzyme" /protein_id="NP_391333.1" /db_xref="EnsemblGenomes-Gn:BSU34530" /db_xref="EnsemblGenomes-Tr:CAB15458" /db_xref="GOA:O06996" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG12423" /db_xref="UniProtKB/Swiss-Prot:O06996" /translation="MAKYRIMTFDGGGTLGALSLQLLNRLARQNPKLISRTHVFSGNS IGSFTALALASGRSPRETLQYFEDEILPAFSISRPGGPVFNQQLPYSGFIKAVRNFFP ADLQLIDLRKRIVVPSFKLYSQKLDRWTPVLFHNFPGSPYLNEKVSDVILRSSGAPAT QRAYQNYVDGYVVATNPSTASIAFAVGKANVPLDQIAVLSIGTGEAPTRLRRDTRGWG MVSADNIRPENLKNLPPNWGVLLDRSPNEPLLPFLQMIAGGNGYYESMVSANLLGDRF FRLDPRIPNFSKTDPAVVPAVIEIANKTNLQPANQFIEKNWGSK*" /label="cotR CDS" gene 2958439..2959401 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /label="cotR gene" S_feature 2959402..2959655 /Source="Nicolas_S_feature" /locus_tag="new_3545605_3545858" /HighExp="BT, S8, S7, B36, S6, Pyr, G/S, S3, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1317" downshifts complement(2959682) /Source="Nicolas_upshifts" /id="D1789" /incds=0 /nref=190 /ntot=241 /MaxReadThrough="3.19421" /MaxDrop="5.60739" /score="16.7489574" /energy="-13.2" /TU="U2713" /idTUdmin="U2713" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" tRNA complement(2959686..2959761) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA (CCG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnQ-Arg tRNA" gene complement(2959686..2959761) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /label="trnQ-Arg gene" promotor_-10 complement(2959788..2959807) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2959809) /Source="Nicolas_upshifts" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2959823..2959826) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2959892..2959898 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2959908..2959983 /Source="Nicolas_S_feature" /locus_tag="new_3546111_3546186" /HighExp="Salt, S3, S4, Etha, S5, LoTm, Gly, M9-stat, BT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1318" upshifts 2959908 /Source="Nicolas_upshifts" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2959913..2959932 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2959960..2959967 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2959981..2960000 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2959985 /Source="Nicolas_upshifts" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="upshifts" CDS 2960031..2960624 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /EC_number="3.4.21.92" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease proteolytic subunit; Maxwell's demon" /protein_id="NP_391334.1" /db_xref="EnsemblGenomes-Gn:BSU34540" /db_xref="EnsemblGenomes-Tr:CAB15459" /db_xref="GOA:P80244" /db_xref="InterPro:IPR001907" /db_xref="InterPro:IPR018215" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR033135" /db_xref="PDB:3KTG" /db_xref="PDB:3KTH" /db_xref="PDB:3KTI" /db_xref="PDB:3KTJ" /db_xref="PDB:3KTK" /db_xref="PDB:3TT6" /db_xref="PDB:3TT7" /db_xref="SubtiList:BG19016" /db_xref="UniProtKB/Swiss-Prot:P80244" /translation="MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSI VSQLLFLAAEDPEKEISLYINSPGGSITAGMAIYDTMQFIKPKVSTICIGMAASMGAF LLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILLLRDKLNKVLAERTGQ PLEVIERDTDRDNFKSAEEALEYGLIDKILTHTEDKK*" /label="clpP CDS" gene 2960031..2960624 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /label="clpP gene" downshifts 2960613 /Source="Nicolas_upshifts" /id="D1790" /incds=0 /nref=292 /ntot=300 /MaxReadThrough="4.45406" /MaxDrop="8.24306" /score="30.2626808" /energy="-14.6" /TU="U2714" /idTUdmin="U2715" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" S_feature 2960658..2961056 /Source="Nicolas_S_feature" /locus_tag="new_3546861_3547259" /HighExp="Etha, dia15, Heat, LoTm, M9-stat, Gly, dia5, Diami, S8, H2O2" /AntisenseName="pgcM" /AntisenseCor="0.13310786898312499" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1319" CDS complement(2960670..2961350) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /EC_number="2.7.1.41" /EC_number="5.4.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 11081794, 15996095" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 11081794, 15996095; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase" /protein_id="NP_391335.1" /db_xref="EnsemblGenomes-Gn:BSU34550" /db_xref="EnsemblGenomes-Tr:CAB15460" /db_xref="GOA:O06995" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR010972" /db_xref="InterPro:IPR010976" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3NAS" /db_xref="SubtiList:BG12422" /db_xref="UniProtKB/Swiss-Prot:O06995" /translation="MKAVIFDLDGVITDTAEYHFLAWKHIAEQIDIPFDRDMNERLKG ISREESLESILIFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLLPGIGRLLCQ LKNENIKIGLASSSRNAPKILRRLAIIDDFHAIVDPTTLAKGKPDPDIFLTAAAMLDV SPADCAAIEDAEAGISAIKSAGMFAVGVGQGQPMLGADLVVRQTSDLTLELLHEEWEQ YRIRESIP*" /label="mdxM CDS" gene complement(2960670..2961350) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /label="mdxM gene" downshifts complement(2960694) /Source="Nicolas_upshifts" /id="D1791" /incds=0 /nref=2 /ntot=36 /MaxReadThrough="3.4944" /MaxDrop="3.50516" /score="-9.43329271" /energy="-14.6" /TU="U2718" /idTUdmin="U2718" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" CDS complement(2961347..2963032) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9573215, 10229946, 1670768" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573215, 10229946, 1670768; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligo-1,4-1,6-alpha-glucosidase (sucrase-maltase-isomaltase)" /protein_id="NP_391336.1" /db_xref="EnsemblGenomes-Gn:BSU34560" /db_xref="EnsemblGenomes-Tr:CAB15461" /db_xref="GOA:O06994" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="PDB:4M56" /db_xref="PDB:4M8U" /db_xref="PDB:4MAZ" /db_xref="PDB:4MB1" /db_xref="SubtiList:BG12421" /db_xref="UniProtKB/Swiss-Prot:O06994" /translation="MSEWWKEAVVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGA DVIWLSPVFDSPQDDNGYDISDYKNMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNH TSDEHAWFAESRKSKDNPYRDYYLWKDPKPDGSEPNNWGSIFSGSAWTYDEGTGQYYL HYFSKKQPDLNWENEAVRREVYDVMRFWMDRGVDGWRMDVIGSISKYTDFPDYETDHS RSYIVGRYHSNGPRLHEFIQEMNREVLSHYDCMTVGEANGSDIEEAKKYTDASRQELN MIFTFEHMDIDKEQNSPNGKWQIKPFDLIALKKTMTRWQTGLMNVGWNTLYFENHDQP RVISRWGNDRKLRKECAKAFATVLHGMKGTPFIYQGEEIGMVNSDMPLEMYDDLEIKN AYRELVVENKTMSEKEFVKAVMIKGRDHARTPMQWDAGKHAGFTAGDPWIPVNSRYQD INVKESLEDQDSIFFYYQKLIQLRKQYKIMIYGDYQLLQENDPQVFSYLREYRGEKLL VVVNLSEEKALFEAPPELIHERWKVLISNYPQERADLKSISLKPYEAVMGISI*" /label="mdxL CDS" gene complement(2961347..2963032) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /label="mdxL gene" CDS complement(2963025..2965298) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /EC_number="2.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16707683, 28527120" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 28527120; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose phosphorylase" /protein_id="NP_391337.1" /db_xref="EnsemblGenomes-Gn:BSU34570" /db_xref="EnsemblGenomes-Tr:CAB15462" /db_xref="GOA:O06993" /db_xref="InterPro:IPR005194" /db_xref="InterPro:IPR005195" /db_xref="InterPro:IPR005196" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR017045" /db_xref="SubtiList:BG12420" /db_xref="UniProtKB/Swiss-Prot:O06993" /translation="MINQRLFEIDEWKIKTNTFNKEHTRLLESLTSLANGYMGVRGNF EEGYSGDSHQGTYIAGVWFPDKTRVGWWKNGYPEYFGKVINAMNFMGIGLYVDGEKID LHQNPIELFEVELNMKEGILRRSAVVRIQDKTVRIRSERFLSLAVKELCAIHYEAECL TGDAVITLVPYLDGNVANEDSNYQEQFWQEEAKGADSHSGHLAAKTIENPFGTPRFTV LAAMANETEGFVHESFKTTEMYVENRYSYQTKASLKKFVIVTTSRDFREEELLSKAKE LLADVVENGYEDAKRRHTDRWKERWAKADIEIKGDEELQQGIRYNIFQLFSTYYGGDA RLNIGPKGFTGEKYGGAAYWDTEAYAVPMYLATAEPEVTKNLLLYRYHQLEAAKRNAA KLGMKGALYPMVTFTGDECHNEWEITFEEIHRNGAICYAIYNYINYTGDRNYMEEYGI DVLVAVSRFWADRVHFSKRKNKYMIHGVTGPNEYENNVNNNWYTNVIAAWTLEYTLQS LESISAEKRRHLDVQEVELEVWREIIQHMYYPFSEELQIFVQHDTFLDKDLQTVDELD PAERPLYQNWSWDKILRSNFIKQADVLQGIYLFNDRFTMEEKRRNFEFYEPMTVHESS LSPSVHAILAAELKLEKKALELYKRTARLDLDNYNHDTEEGLHITSMTGSWLAIVHGF AGMRTANETLSFAPFLPKEWDEYSFNINYRNRLINVTVDEKRVIFELVKGEPLHMNVY EEPVVLQGRCERRTPNE*" /label="mdxK CDS" gene complement(2963025..2965298) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /label="mdxK gene" CDS complement(2965276..2966160) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16707683, 16850406, 20436965; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative component of maltodextrin transporter" /protein_id="NP_391338.1" /db_xref="EnsemblGenomes-Gn:BSU34580" /db_xref="EnsemblGenomes-Tr:CAB15463" /db_xref="GOA:O06992" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG12419" /db_xref="UniProtKB/Swiss-Prot:O06992" /translation="MKNLENKSFIIRCLKAAASPSGVCRYGNTFSWLQLSFLFLFLTA CLMAPLAVSFVKMDRFSVSSFMPSAIQGVNDQFADQLQGFQIRNGKLTGGKSSERIED GQNVMAVDMKHEYETSGENGRLKVTGFENAIIFQPDQLVITDQNETGFSVGYAKMDVK LEKPNVHDVEVLIDTLWLAQYKPMIMMLAYTVVSMIQLLLTFVLAGGLWITKISNMVS IASFKEAASIAICASALPAFAAAAIGMVHFDLITVLMIHSCGVTLMISFAFRYLTKTR RDNGNLHSGGNDDKSAVI*" /label="mdxJ CDS" gene complement(2965276..2966160) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /label="mdxJ gene" CDS complement(2966166..2967002) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transporter (permease)" /protein_id="NP_391339.1" /db_xref="EnsemblGenomes-Gn:BSU34590" /db_xref="EnsemblGenomes-Tr:CAB15464" /db_xref="GOA:O06991" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12418" /db_xref="UniProtKB/Swiss-Prot:O06991" /translation="MNASTARMLNKICTYLFLTLLSIVIIYPLLITASSAFRVGNSAA FQLDFSGSWTLDHFKRLFDETLYLNWYSNTLVIALSVMVLQVTIVTLAGYSYSRYRFA GRKKSLIFFLIIQMVPTMAALTAFYVLAMLIGALDQYWFLTAIYIGGGIPMNTWLMKG YFDTVPREIDEAARIDGAGHLRIFASIVLPLVKPMLAVQALWAFMAPFGDYLLTKFLL RSPERLTIAVGLQSFISNPQQQKVALFAAGAILAALPICVLFFFLQKNFVSGLTAGGT KG*" /label="mdxG CDS" gene complement(2966166..2967002) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /label="mdxG gene" CDS complement(2967003..2968310) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transport system (permease)" /protein_id="NP_391340.1" /db_xref="EnsemblGenomes-Gn:BSU34600" /db_xref="EnsemblGenomes-Tr:CAB15465" /db_xref="GOA:O06990" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12417" /db_xref="UniProtKB/Swiss-Prot:O06990" /translation="MNKHHTLTKQKRKAGLLSIIPGLGQIANQQLSKGLLFLAITGLF AFELCVFGIQALTGLMTLGSVPGEDHSLFMLIEGTLQLIVTMIFLMFYIFNIHDSRKT AAMKAAGLEVNTTAKDMICHAGDKGFPYLFTLPAYIMMVFVIIFPVLVTLFVALTNYD FYHIPPNRLIDWVGFKNFLNIFFLGSYRETFVNVLGWTVIWTICATTLQIILGIVTAL FVNQDFIKGKRIFRMIFLFPWAVPAFITIMSFSNMFNDSIGAVNAQVIPLFNHLPFVE LPAIAWKTDPFWTKTALIMIQTWLGFPYIYVMVTGVLQAIPGELYEAAKIDGATFIQR FRHITFPMILFATAPVMITQYTFNFNNFSIIYLFNEGGPGSAGAGAGSTDILISWIYK LTTGTSPQYSVAAAVTLLISFIVIGISLIAFKKSNAFGNEEVM*" /label="mdxF CDS" gene complement(2967003..2968310) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /label="mdxF gene" promotor_-35 2967368..2967377 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2967390..2967409 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2967394 /Source="Nicolas_upshifts" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2968350..2969603) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="maltose/maltodextrin-binding lipoprotein" /protein_id="NP_391341.1" /db_xref="EnsemblGenomes-Gn:BSU34610" /db_xref="EnsemblGenomes-Tr:CAB15466" /db_xref="GOA:O06989" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12416" /db_xref="UniProtKB/Swiss-Prot:O06989" /translation="MVLLKKGFAILAASFLAIGLAACSSSKNPASSDGKKVLTVSVEE TYKEYIESIKTKFEKENDVTVKIVEKQMFEQLEALPLDGPAGNAPDVMLAAYDRIGGL GQQGHLLDIKPSNTKSFGDKEMQQVTVDGKVYGMPLVIETLILYYNKDLLKTAPKTFK DLEKLTEDPRFAFASEKGKSTGFLAKWTDFYMSYGLLAGYGGYVFGKNGTDSGDIGLN NKGAVEAVKYAEKWFETYWPKGMQDNSSADDFIQQMFLEGKAAAIIGGPWSAANYKEA KLNYGAAPIPTLPNGEEYAPFAGGKGWVASKYTKEPELAEKWLEYAANDANAYAFYED TNEVPANTAARKKADEQKNELTSAVIKQYETATPTPNIPEMAEVWTGAESLIFDAASG KKSTQTSANDAVNVIKENIKEKYVK*" /label="mdxE CDS" gene complement(2968350..2969603) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /label="mdxE gene" S_feature complement(2969604..2969698) /Source="Nicolas_S_feature" /locus_tag="new_3555807_3555901_c" /HighExp="T1.0H, T0.30H, BC, T1.30H, M40t90, M0t90, BI, B60, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.804" /TUlongSig="NA" /TUlongPSig="NA" /label="S1320" CDS complement(2969699..2971468) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10825545, 15650689, 16707683, 19465663, 27871383, 27871383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10825545, 15650689, 16707683, 19465663, 27871383, 27871383; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maltogenic alpha-amylase" /protein_id="NP_391342.1" /db_xref="EnsemblGenomes-Gn:BSU34620" /db_xref="EnsemblGenomes-Tr:CAB15467" /db_xref="GOA:O06988" /db_xref="InterPro:IPR004185" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013777" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12415" /db_xref="UniProtKB/Swiss-Prot:O06988" /translation="MMEYAAIHHQPFSTDAYSYDGRTVHIKIRTKKGDADHIRFIWGD PYEYNDGKWSANEQPMRKIAATEMHDYWFAEVVPPFRRLQYAFVVTDDHEDIFFGSSG VCPYNEKTLETIHYYFKFPFVHEADTFQAPEWVKSTVWYQIFPERFANGREDLSPKNA LPWGSKDPDVNDFFGGDLQGIVDKLDYLEDLGVNGIYLTPIFSAPSNHKYDTLDYFSI DPHFGDPELFRTLVSQLHQRGMRIMLDAVFNHIGSASPQWQDVVKNGDQSRYKDWFHI HSFPVTDDNYDRFAFTADMPKLNTANPEVQKYLLDIALYWIREFDIDGWRLDVANEVD HVFWKTFRQAVSTEKPDVYILGEIWHSAEPWLRGDEFHAAMNYPFTEPMIEYFADQTI SASRMAHRVNAHLMNGMKQANEVMFNLLDSHDTKRLLTRCRNDEKKARALLAFMFAQT GSPCIYYGTEIGLNGENDPLCRKCMVWEKEKQNQDMLQFMKRLIALRKQENTLLTEGH LEWNLLDDKNDFISFSRTLDEKILIYFFNQGNVVQHVSLRELNIDRNKKICDAWTEQP LQHHDVIAVQPGEFLILSAAAPV*" /label="mdxD CDS" gene complement(2969699..2971468) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /label="mdxD gene" promotor_-35 2971389..2971394 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2971410..2971428 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2971420 /Source="Nicolas_upshifts" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2971506..2971525) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2971519) /Source="Nicolas_upshifts" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2971538..2971545) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2971581..2972531) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16707683, 23951303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 23951303; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the maltodextrin operon (LacI family)" /protein_id="NP_391343.1" /db_xref="EnsemblGenomes-Gn:BSU34630" /db_xref="EnsemblGenomes-Tr:CAB15468" /db_xref="GOA:O06987" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12414" /db_xref="UniProtKB/Swiss-Prot:O06987" /translation="MATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELN YIPNYAARALVQNRTQVVKLLILEEMDTTEPYYMNLLTGISRELDRNHYALQLVTRNS LNIGQCDGIIATGLRKNDFEGVIKAFEKPLVVFGQNEMGYDFIDVNNEKGTFMATRHV MGLGEREVVFFGIDLDEPFERAREQGYIRAMNKSFKKSNMFRIDNSSKKSECLARELL KSMDNQAAFVCASDRIALGVIRAAQSLGKRIPEDVAVTGNDGVFLDRISSPRLTTVRQ PVVEMGEACAKMLLKKMNEDGAAQGSLFFEPELIVRESTL*" /label="mdxR CDS" gene complement(2971581..2972531) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /label="mdxR gene" promotor_-10 complement(2972546..2972564) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2972559) /Source="Nicolas_upshifts" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2972576..2972584) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2972665) /Source="Nicolas_upshifts" /id="D1792" /incds=0 /nref=134 /ntot=243 /MaxReadThrough="0.22626" /MaxDrop="5.17193" /score="21.4455132" /energy="-10" /TU="NA" /idTUdmin="U2720" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2972737..2973312) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391344.1" /db_xref="EnsemblGenomes-Gn:BSU34640" /db_xref="EnsemblGenomes-Tr:CAB15469" /db_xref="InterPro:IPR005269" /db_xref="InterPro:IPR031100" /db_xref="PDB:1T35" /db_xref="SubtiList:BG12413" /db_xref="UniProtKB/Swiss-Prot:O06986" /translation="MKTICVFAGSNPGGNEAYKRKAAELGVYMAEQGIGLVYGGSRVG LMGTIADAIMENGGTAIGVMPSGLFSGEVVHQNLTELIEVNGMHERKAKMSELADGFI SMPGGFGTYEELFEVLCWAQIGIHQKPIGLYNVNGYFEPMMKMVKYSIQEGFSNESHL KLIHSSSRPDELIEQMQNYSYPILEKKWTEI*" /label="yvdD CDS" gene complement(2972737..2973312) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /label="yvdD gene" downshifts complement(2972749) /Source="Nicolas_upshifts" /id="D1793" /incds=0 /nref=30 /ntot=209 /MaxReadThrough="4.23893" /MaxDrop="3.6086" /score="21.4455132" /energy="-10" /TU="U2720" /idTUdmin="U2720" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2973355..2973374) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2973361..2973368 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2973371) /Source="Nicolas_upshifts" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="upshifts" upshifts 2973378 /Source="Nicolas_upshifts" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2973381..2973400 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2973389..2973396) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2973429..2973749 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16120674, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrophosphohydrolase" /protein_id="NP_391345.1" /db_xref="EnsemblGenomes-Gn:BSU34650" /db_xref="EnsemblGenomes-Tr:CAB15470" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011411" /db_xref="SubtiList:BG12412" /db_xref="UniProtKB/Swiss-Prot:O32263" /translation="MQLADAEKWMKEFYEKRGWTEYGPFIRVGFLMEEAGELARAVRA YEIGRDRPDEKESSRAEQKQELIEEMGDVIGNIAILADMYGVSLEDVMKAHQEKLTKR FEHA*" /label="yvdC CDS" gene 2973429..2973749 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /label="yvdC gene" downshifts 2973730 /Source="Nicolas_upshifts" /id="D1794" /incds=0 /nref=134 /ntot=247 /MaxReadThrough="2.19085" /MaxDrop="5.46819" /score="35.8658106" /energy="-11.6" /TU="NA" /idTUdmin="U2721" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2973776) /Source="Nicolas_upshifts" /id="D1795" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="0.462300000000001" /MaxDrop="6.90114" /score="30.4681035" /energy="-11.3" /TU="NA" /idTUdmin="U2722" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(2973776..2975368) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion transporter" /protein_id="NP_391346.1" /db_xref="EnsemblGenomes-Gn:BSU34660" /db_xref="EnsemblGenomes-Tr:CAB15471" /db_xref="GOA:O06984" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12411" /db_xref="UniProtKB/Swiss-Prot:O06984" /translation="MRFSGRFKGYNLQKFQKDLIAGIVVGVVAIPLGMAFAIASGVEP EYGLYTVVIAGICISLFGGSKYQIGGPTGAFVPILFGIIMQYGLENLLIAGFMAGVML VLFGLFKLGKIMKFVPKPVIVGFTAGIAVLIFTEQIANFLGLRNVEKHENFHHNMFEI VQQLGTFNVYAILTAVIGLVILLVSAKVMPKVPGALLALLISTVVAVVFFPDRMATIG STYGEIPRHLPEFQFPELTLDKMVMLFPAALVIALLGGLESILSAMVADNMKGSKHDS NKELVGQGIANMAAPLFGGIPATGAIARTATNIKNGAVSPVSGVVHGVVVLLVLLVFA PYASHVPLASMAPILMVVAWNMSERKEVANMLRLKNADSFILAATFALTVLFDLIIGV ATGLLLAFVFFIRRMSEATRIHNQETHPVLAKREDPSVSMYAIEGPLFFGSIDSLESS LLEHVQKKPKTLILLMNKVHYMDTSAEAVLGNIMNRIKRHNGKLMIVGLQSQPKELLH KTGLFHKIGKQHFFDHHDEITG*" /label="yvdB CDS" gene complement(2973776..2975368) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /label="yvdB gene" CDS complement(2975387..2975980) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /EC_number="4.2.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10611359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carbonic anhydrase" /protein_id="NP_391347.1" /db_xref="EnsemblGenomes-Gn:BSU34670" /db_xref="EnsemblGenomes-Tr:CAB15472" /db_xref="GOA:O06983" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG12410" /db_xref="UniProtKB/Swiss-Prot:O06983" /translation="MNQMVSLTSILEHNQRFVSEKKYEPYKTTKFPSKKLVIVTCMDT RLTELLPQAMGLKNGDAKIVKNAGAIVSHPFGSVMRSILVAIYELQAEEVCIVGHHEC GMSGLNASSILEKAKERGVEDSCLNLLTSAGLDLKTWLTGFHSVEESVSHSVNMIKNH PLLPKKVPVHGLVIHPETGKLDVVINGYETELINNHS*" /label="yvdA CDS" gene complement(2975387..2975980) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /label="yvdA gene" promotor_-10 complement(2976022..2976041) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2976035) /Source="Nicolas_upshifts" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2976056..2976060) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2976106..2976111 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2976127..2976145 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2976128 /Source="Nicolas_upshifts" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2976301..2976308 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2976322..2976341 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2976326 /Source="Nicolas_upshifts" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" CDS 2976363..2977340 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /EC_number="1.1.1.215" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811658, 25769838; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-ketogluconate reductase; hydroxypyruvate / glyoxylate reductase" /protein_id="NP_391348.1" /db_xref="EnsemblGenomes-Gn:BSU34680" /db_xref="EnsemblGenomes-Tr:CAB15473" /db_xref="GOA:O32264" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12409" /db_xref="UniProtKB/Swiss-Prot:O32264" /translation="MLKPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLK EAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTL DDTVADLAFSLILSSARRVAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIG EQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETY HMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNP LLQLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQGQTPKNLTREFQ*" /label="yvcT CDS" gene 2976363..2977340 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /label="yvcT gene" downshifts 2977312 /Source="Nicolas_upshifts" /id="D1796" /incds=0 /nref=223 /ntot=269 /MaxReadThrough="2.44036" /MaxDrop="5.93476" /score="1.05732532" /energy="-14.7" /TU="NA" /idTUdmin="U2724" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2977378..2979318) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (permease)" /protein_id="NP_391349.1" /db_xref="EnsemblGenomes-Gn:BSU34690" /db_xref="EnsemblGenomes-Tr:CAB15474" /db_xref="GOA:O06981" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG12408" /db_xref="UniProtKB/Swiss-Prot:O06981" /translation="MNLRTIARKNILGNLQRYVAYFLSCVFAVSVFFVFTSFIFHPDV NEDNIYGGSLVKTCLSAALVVIIVFCIFFITYSNSAFLQARKKEFGLLTLFGTSKQQL RKMIYYEQSLISLAAIAAGIGAGLLFSKLFFMIMTWMLSVKVPISFAIVPKAFVMTIA GFLILFQTLLILSLGRIRKLEIIELIKSAKKPKSLPVYSKWLTVLSLLCLGSGYYLSA TANAIDMMFRVFPILILVLIGTYFFFTQSSVAFFRMLYRKKHSFYKGTNIIVRSNMIF RLKDHARMLFLTSVITAVILTATGVIYMFYSDLQRQEEQSIPQSVSWVEKDASRFQVM KPETAENTLKKAHAVITYKVDATGIPVTFQSDLPYGNKKMEAEALLISEKVYNQVAKE KGFPVIHLQENEAFINVSFQMMVKDTFGEGETAAFHMKSGKTLSYVMKKQQNKGILMS VDGVSRLLVVSEKSFDSLSQDVPLKEQMRMVGYELEHWQETVDVSEKLENMVPKEHTS DFQTRAPSYQIVKQGVALMLFIGLFVSVLFFIVQGSMLYLRMFTEIEDTGVQVLALKR IGVTDKEIHSILGKQIGFLFFIPFIAGTIHAGFAYAALSNMLNSNLFLEAVIVIFIYF VFQALYYIVTRHIYKRAVLQRM*" /label="psdB CDS" gene complement(2977378..2979318) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /label="psdB gene" downshifts complement(2977402) /Source="Nicolas_upshifts" /id="D1797" /incds=0 /nref=11 /ntot=187 /MaxReadThrough="0.26118" /MaxDrop="4.59213" /score="26.9028733" /energy="-14.7" /TU="NA" /idTUdmin="U2725" /TUdmin=34 /isTUend="FALSE" /label="downshifts" CDS complement(2979293..2980072) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12432961, 14651641, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (ATP-binding protein)" /protein_id="NP_391350.1" /db_xref="EnsemblGenomes-Gn:BSU34700" /db_xref="EnsemblGenomes-Tr:CAB15475" /db_xref="GOA:O06980" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12407" /db_xref="UniProtKB/Swiss-Prot:O06980" /translation="MNVLQTTNLSKTYYSNKGTISYQALSAFDLSVSKGEFVGIMGPS GSGKTTLLNLLATIDKPTQGEMMINGIQPKTLKDQELALFRRRELGFVFQDFNLLDTL TIRENILLPLALDKVKLREMEARLDELADTLQIKHILDHRTYEVSGGQQQRAACARAI IHNPALILADEPTGNLDSKSAKQVMNTLAQLNEEKEATILLVTHDATAASFCKRIVFI KDGRFFSEIHRGTNRQVFYQSILDTLSVLGGDFHEFENYRP*" /label="psdA CDS" gene complement(2979293..2980072) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /label="psdA gene" S_feature complement(2980073..2980154) /Source="Nicolas_S_feature" /locus_tag="new_3566276_3566357_c" /HighExp="LBGtran, M0t45, H2O2, C30, Lbexp, Lbstat, LBGstat, dia0, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1321" CDS complement(2980155..2981225) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [PsdR] response to lantibiotics (nisin and gallidermin)" /protein_id="NP_391351.1" /db_xref="EnsemblGenomes-Gn:BSU34710" /db_xref="EnsemblGenomes-Tr:CAB15476" /db_xref="GOA:O06979" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12406" /db_xref="UniProtKB/Swiss-Prot:O06979" /translation="MLKTYLIDRLAIILFSLLGIGSAMLIAYLSIVESGAEPSKENMM YIWILPGTLLAAGFAADYVRQFSFLTYVKKLAEQASSSNDIGQSLKARKPRTGEQALW TKMINALGQQYESRLSQYINQQKQHYTFTNQWVHHMKTPVSVISLMIQEGKNGTSSSF PTFLEELEDENERFRHGLDMMLQTARLEEFAFDVKPQTFDLAEMVRSLINQEKRQFIK RRLFPTLHVPPNAVQISSDQKWLSFVVEQILFNALKYSKQGVGDPITIRIETQGHETR LSVADEGIGIPPQDLPRIFDAFFTGENGRTMKEATGMGLYLAKQVCSRLGHKLYAESK EGAGTVMTIVFSSDTLVNVTAL*" /label="psdS CDS" gene complement(2980155..2981225) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /label="psdS gene" CDS complement(2981219..2981932) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [PsdS] responding to lipid II-binding lantibiotics (nisin and gallidermin)" /protein_id="NP_391352.1" /db_xref="EnsemblGenomes-Gn:BSU34720" /db_xref="EnsemblGenomes-Tr:CAB15477" /db_xref="GOA:O06978" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12405" /db_xref="UniProtKB/Swiss-Prot:O06978" /translation="MYRILLVEDDERIASLLGGHLQKYGYEVKIAEQLNDIKLEFAEM KPDLVLLDINLPFFDGFYWCRQIRTISNAPIIFISARTDELNQVMAIENGGDDYITKP FHLEVVMAKIKSVLRRTYGEYSPSLPQESRIVELGGLTIYPDQNEAEWNSVRILFSQK EFQLLSIFVREHKKIVSRDELLEALWDDVDFVDDNTLTVNVNRLRRKLENAGLTDCIS TIRGQGYQFQVNRKDEAEC*" /label="psdR CDS" gene complement(2981219..2981932) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /label="psdR gene" promotor_-10 complement(2981978..2981997) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2981990) /Source="Nicolas_upshifts" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2981992..2982253) /Source="Nicolas_S_feature" /locus_tag="new_3568195_3568456_c" /HighExp="H2O2, G135, G180, Cold, Paraq, G150, dia15, Oxctl, LBGexp, C30" /AntisenseName="yvzJ" /AntisenseCor="0.56014644713727801" /AntisenseRegPval="-22.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1322" promotor_-35 complement(2982010..2982013) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2982013..2982020 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2982031..2982050 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2982036 /Source="Nicolas_upshifts" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2982079..2982288 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="YP_003097790.1" /db_xref="EnsemblGenomes-Gn:BSU34729" /db_xref="EnsemblGenomes-Tr:CAX52696" /db_xref="GOA:C0H3R7" /db_xref="UniProtKB/Swiss-Prot:C0H3R7" /translation="MKKIMLFLAMTSILSACQPNYTGKYIEIGDTLTDYTKECFKENE IPYKYEKGKLYIPEDAFDTAIYTCS*" /label="yvzJ CDS" gene 2982079..2982288 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /label="yvzJ gene" downshifts 2982266 /Source="Nicolas_upshifts" /id="D1798" /incds=0 /nref=7 /ntot=138 /MaxReadThrough="1.16039" /MaxDrop="3.61604" /score="-5.58790836" /energy="-11.4" /TU="NA" /idTUdmin="U2726" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2982298) /Source="Nicolas_upshifts" /id="D1799" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="3.16808" /MaxDrop="2.84175" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(2982324..2983088) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10876241; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative arylamine N-acetyltransferase" /protein_id="NP_391353.1" /db_xref="EnsemblGenomes-Gn:BSU34730" /db_xref="EnsemblGenomes-Tr:CAB15478" /db_xref="GOA:O06977" /db_xref="InterPro:IPR001447" /db_xref="SubtiList:BG12404" /db_xref="UniProtKB/Swiss-Prot:O06977" /translation="MIKMSDFLKDCFQKIGWEKDHVSFGDLPLFLKAMAYRFPFENRA VLAKENYKITKEELWRRLLKDQHGGLCYDLNGFLYFVLREAGFHVKLIRGTVYAGDQE GWALEGTHAAVWLSAENGDYLVDIGFGINLALQPIPLSGETVQSPVGSFRIKKEETEK GSYVLLMDKGEGWQIGYAFTLEESDLGDLDNMKDIIHSHEKSPFNKSLLASKLTPSGR MVMSERHFTIYENGGNIQKSDIGPSGFEEKLNTHFL*" /label="yvcN CDS" gene complement(2982324..2983088) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /label="yvcN gene" downshifts complement(2982346) /Source="Nicolas_upshifts" /id="D1800" /incds=0 /nref=143 /ntot=253 /MaxReadThrough="3.19848" /MaxDrop="6.45069" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2983089..2983346) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="catabolite repression HPr-like protein" /protein_id="NP_391354.1" /db_xref="EnsemblGenomes-Gn:BSU34740" /db_xref="EnsemblGenomes-Tr:CAB15479" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1K1C" /db_xref="PDB:1MO1" /db_xref="PDB:1MU4" /db_xref="PDB:1ZVV" /db_xref="PDB:2AK7" /db_xref="PDB:2RLZ" /db_xref="SubtiList:BG12403" /db_xref="UniProtKB/Swiss-Prot:O06976" /translation="MVQQKVEVRLKTGLQARPAALFVQEANRFTSDVFLEKDGKKVNA KSIMGLMSLAVSTGTEVTLIAQGEDEQEALEKLAAYVQEEV*" /label="crh CDS" gene complement(2983089..2983346) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /label="crh gene" CDS complement(2983370..2984320) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10986251, 17603302, 19836336, 24097947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative morphogen" /protein_id="NP_391355.1" /db_xref="EnsemblGenomes-Gn:BSU34750" /db_xref="EnsemblGenomes-Tr:CAB15480" /db_xref="GOA:O06975" /db_xref="InterPro:IPR003802" /db_xref="InterPro:IPR018478" /db_xref="InterPro:IPR023054" /db_xref="InterPro:IPR027434" /db_xref="InterPro:IPR033981" /db_xref="SubtiList:BG12402" /db_xref="UniProtKB/Swiss-Prot:O06975" /translation="MSFASETKKELTNLEVKDCCINAELSALIRMNGALSFTNRHLVL DVQTENAAIARRIYTLLKKQYDVSVELLVRKKMRLKKNNVYIVRFSENAKAILEDLKI LGENFVFERSISKELVKKRCCKRSYMRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDS LCDLLNEFQLNSKTLERKKGYITYLKEAEKITEFLNVIGAHNSLLRFEDVRIVRDMRN SVNRLVNCETANLNKTIGASLRQVENIKYIDERIGLEALPEKLREIAQLRIDYQEVTL KELGEMVASGKISKSGINHRLRKLDEIAEQLRTGQTVTLK*" /label="whiA CDS" gene complement(2983370..2984320) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /label="whiA gene" CDS complement(2984343..2985296) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159; Product type f: factor" /codon_start=1 /transl_table=11 /product="gluconeogenesis morphogenetic factor (UDP-sugar binding)" /protein_id="NP_391356.2" /db_xref="EnsemblGenomes-Gn:BSU34760" /db_xref="EnsemblGenomes-Tr:CAB15481" /db_xref="GOA:O06974" /db_xref="InterPro:IPR002882" /db_xref="InterPro:IPR010119" /db_xref="SubtiList:BG12401" /db_xref="UniProtKB/Swiss-Prot:O06974" /translation="MGQKPKIAIFGGGTGLSVLLRGLKHKPVDITAIVTVADDGGSSG RLRNELKIPPPGDIRNVLAALSDVEPLVEDLFQHRFNKGNDLTGHSLGNLILAAMTNI TGDFFHAVTEMSKVLNVRGKVLPAANASVVLHAEMEDGRVVSGESTIPEYGQRIKRVF LTPEQIDPLPETIDVIREADLIIIGPGSLYTSILPNLLVPKIGEEVIKAPAKKVYICN VMTQPGETLHYTAADHVKALNQHMGCGFIDTILVNSEDIPDEIKRKYEMESARPVDFD IEELKAMGLEVIRDQIVTYKNDVIRHDTHKVASLLVDLLKE*" /label="mgfK CDS" gene complement(2984343..2985296) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /label="mgfK gene" CDS complement(2985298..2986185) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /function="15.6: DNA transformation" /experiment="publication(s) with functional evidences, PMID:18334534, 19074378, 21179021, 21709426" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18334534, 19074378, 21179021, 21709426; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase possibly involved in regulator sRNA degradation" /protein_id="NP_391357.1" /db_xref="EnsemblGenomes-Gn:BSU34770" /db_xref="EnsemblGenomes-Tr:CAB15482" /db_xref="GOA:O06973" /db_xref="InterPro:IPR005337" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12400" /db_xref="UniProtKB/Swiss-Prot:O06973" /translation="MSVSESHDIQLVIITGMSGAGKTVAIQSFEDLGYFCVDNLPPSL LPKFLELMKESNSKMSKVALVMDLRGREFFDRLIEALDEMAENPWITPRILFLDAKDS ILVTRYKETRRSHPLAATGLPLEGIALERELLEELKGRSQIIYDTSDMKPRDLREKIV KHFATNQGETFTVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIESMRPLTGKDKEVSS YVMKWNETQKFNEKLIDLLSFMLPSYKREGKSQVVIAIGCTGGQHRSVTLAENLADYF KKDYYTHVTHRDIEKRSRK*" /label="yvcJ CDS" gene complement(2985298..2986185) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /label="yvcJ gene" CDS complement(2986210..2986686) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /EC_number="3.6.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative triphosphate pyrophosphate hydrolase" /protein_id="NP_391358.1" /db_xref="EnsemblGenomes-Gn:BSU34780" /db_xref="EnsemblGenomes-Tr:CAB15483" /db_xref="GOA:O06972" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG12399" /db_xref="UniProtKB/Swiss-Prot:O06972" /translation="MTYLQRVTNCVLQTDDKVLLLQKPRRGWWVAPGGKMESGESVRD SVIREYREETGIYIINPQLKGVFTFIIKDGDHIVSEWMMFTFVADSYTGQNVSESEEG KLQWHDVNDIQNLPMAPGDGHILDFMMKGQGLLHGTFTYTPEFELLSYRLDPQHIK*" /label="yvcI CDS" gene complement(2986210..2986686) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /label="yvcI gene" promotor_-10 complement(2986706..2986725) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2986720) /Source="Nicolas_upshifts" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2986741..2986745) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2986764..2986783) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2986777) /Source="Nicolas_upshifts" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2986798..2986801) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2986853..2987003) /Source="Nicolas_S_feature" /locus_tag="new_3573056_3573206_c" /HighExp="dia15, Diami, dia5, H2O2, Etha, LPhT, Cold, Paraq, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1323" downshifts complement(2986896) /Source="Nicolas_upshifts" /id="D1801" /incds=0 /nref=9 /ntot=78 /MaxReadThrough="6.94979" /MaxDrop="3.73811" /score="11.9453839" /energy="-11" /TU="U2729,U2733" /idTUdmin="U2734" /TUdmin=2904 /isTUend="FALSE" /label="downshifts" CDS complement(2987004..2987954) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /EC_number="1.8.1.9" /function="16.6: Maintain" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14597697, 15659166, 23813734, 24401092" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14597697, 15659166, 23813734, 24401092; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin reductase" /protein_id="NP_391359.1" /db_xref="EnsemblGenomes-Gn:BSU34790" /db_xref="EnsemblGenomes-Tr:CAB15484" /db_xref="GOA:P80880" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR005982" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12398" /db_xref="UniProtKB/Swiss-Prot:P80880" /translation="MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMIERGIPGGQM ANTEDVENYPGFESILGPELSNKMFEHAKKFGAEYAYGDIKEVIDGKEYKVVKAGSKE YKARAVIIAAGAEYKKIGVPGEKELGGRGVSYCAVCDGAFFKGKELVVVGGGDSAVEE GVYLTRFASKVTIVHRRDKLRAQSILQARAFDNEKVDFLWNKTVKEIHEENGKVGNVT LVDTVTGEESEFKTDGVFIYIGMLPLSKPFENLGITNEEGYIETNDRMETKVEGIFAA GDIREKSLRQIVTATGDGSIAAQSVQHYVEELQETLKTLK*" /label="trxB CDS" gene complement(2987004..2987954) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /label="trxB gene" S_feature complement(2987955..2988042) /Source="Nicolas_S_feature" /locus_tag="new_3574158_3574245_c" /HighExp="dia5, Diami, dia15, H2O2, Etha, Salt, Cold, Paraq, LPhT, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1324" promotor_-10 complement(2988031..2988050) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2988042) /Source="Nicolas_upshifts" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2988044..2988135) /Source="Nicolas_S_feature" /locus_tag="new_3574247_3574338_c" /HighExp="Cold, Oxctl, G180, G135, Paraq, C30, LBGexp, G150, S1, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1325" promotor_-35 complement(2988065..2988068) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2988083..2988089 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2988103..2988121 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2988117 /Source="Nicolas_upshifts" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="upshifts" S_feature 2988118..2991504 /Source="Nicolas_S_feature" /locus_tag="new_3574321_3577707" /HighExp="Sw, M9-stat, B60, T0.30H, Gly, BC, B36, T1.0H, Salt, C30" /AntisenseName="yvcD" /AntisenseCor="-0.261780844003138" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1326" CDS complement(2988160..2989581) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /EC_number="3.4.-.-" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted cell wall DL-endopeptidase" /protein_id="NP_391360.1" /db_xref="EnsemblGenomes-Gn:BSU34800" /db_xref="EnsemblGenomes-Tr:CAB15485" /db_xref="GOA:P40767" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG11023" /db_xref="UniProtKB/Swiss-Prot:P40767" /translation="MRKSLITLGLASVIGTSSFLIPFTSKTASAETLDEKKQKIESKQ SEVASSIEAKEKELTELQENQSKIEKELKDINDKALDTSNKIEDKKEENDKTKEEIKK LKKEIKETEARIEKRNEILKKRVRSLQESGGSQGYIDVLLGSTSFGDFISRATAVSSI VDADKDLIKQQEQDKAKLEDSEADLNDKLKEVQAALAKLETMQKDLDKQLNEKDKLFD EAKASQKKTAKAISELKSEASELANQKANTEAEQARIKKEQEAAAALIKKQEEAQKAS DETQTDDSQTATTESSKASSSDDSSDNSSDNSSNGSSNSSSNGSSSKKSSGSNSNSGG TVISNSGGIEGAISVGSSIVGQSPYKFGGGRTQSDINNRIFDCSSFVRWAYASAGVNL GPVGGTTTDTLVGRGQAVSASEMKRGDLVFFDTYKTNGHVGIYLGNGTFLNDNTSHGV SVDSMSNPYWKAAFKGVVRRVVQ*" /label="cwlO CDS" gene complement(2988160..2989581) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /label="cwlO gene" downshifts complement(2988180) /Source="Nicolas_upshifts" /id="D1802" /incds=0 /nref=8 /ntot=106 /MaxReadThrough="6.31311" /MaxDrop="3.4602" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1620 /isTUend="FALSE" /label="downshifts" downshifts complement(2988304) /Source="Nicolas_upshifts" /id="D1803" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="7.07718" /MaxDrop="2.13349" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" misc_feature 2989208..2989212 /Source="Nicolas_upshift_promotors" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2989218 /Source="Nicolas_upshifts" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2989497..2989501 /Source="Nicolas_upshift_promotors" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2989504 /Source="Nicolas_upshifts" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2989582..2989779) /Source="Nicolas_S_feature" /locus_tag="new_3575785_3575982_c" /HighExp="S1, Cold, T-3.40H, M9-exp, MG t5, MG 5, MG 15, T-5.40H, GM-0.2, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1327" downshifts 2989702 /Source="Nicolas_upshifts" /id="D1804" /incds=0 /nref=2 /ntot=119 /MaxReadThrough="6.41604" /MaxDrop="3.8522" /score="6.14322693" /energy="-7.6" /TU="U2730,U2731" /idTUdmin="U2731" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2989767..2989786) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-10" upshifts complement(2989779) /Source="Nicolas_upshifts" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" promotor_-35 complement(2989798..2989805) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-35" CDS complement(2989962..2991416) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391361.1" /db_xref="EnsemblGenomes-Gn:BSU34810" /db_xref="EnsemblGenomes-Tr:CAB15486" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12396" /db_xref="UniProtKB/Swiss-Prot:O06968" /translation="MGKHTSEHKNHAQIVQLLQDGQYFFHKGLKAYKERNLKRASKLI QRAVHLEPEDSEMLSQLAVIYSEMGQYQESNDLLDYIMANLEAEMPECHYFKANNFAH LGLFQEAYKEAAAYSDADPDGEFAEENDSLLDLLDLGDDGIEDSLYDQDELLVKQDRA KSLLESGQLAEAVAALEEITTEYPELWSAYNNLALAYFYSGNVVKAKQTAYEVLSHNE GNLHALCNLLVFYYYEREDEKVAELSDQLSNVYPMLLEQRYKLGATLALVGRYEIGYK WLKSLYKTGFEGDDTFFYWLSCSAYFTGHTDFAETIWRKVESQYPGEDRPAPWIERRE ALPSSVEQRLAAYYISSTKGETEHLEAVIRSKRITAPFETHFVKLLLNGDSAAADVSE DALFAYQTVKLLEQAEKEEMKTEVMSCWVFHVIQQIRAAAPLKNEKGWAAAICYIWKE AHGKQDTKKDTAARFGISPATLTKYMKYIDDILE*" /label="yvcD CDS" gene complement(2989962..2991416) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /label="yvcD gene" downshifts complement(2989982) /Source="Nicolas_upshifts" /id="D1805" /incds=0 /nref=11 /ntot=190 /MaxReadThrough="3.36188" /MaxDrop="3.98985" /score="16.3455178" /energy="-9.1" /TU="U2734" /idTUdmin="U2734" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" S_feature complement(2991417..2991541) /Source="Nicolas_S_feature" /locus_tag="new_3577620_3577744_c" /HighExp="LBGstat, Sw, Cold, BC, BI, Lbexp, dia0, G150, LBGtran, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1328" downshifts 2991462 /Source="Nicolas_upshifts" /id="D1806" /incds=0 /nref=4 /ntot=36 /MaxReadThrough="1.81602" /MaxDrop="3.41181" /score="7.59889121" /energy="-9.9" /TU="NA" /idTUdmin="U2730" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2991542..2993311) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16405427, 18215075, 21077936, 22711831, 24630999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16405427, 18215075, 21077936, 22711831, 24630999; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (ATP-binding and permease protein)" /protein_id="NP_391362.1" /db_xref="EnsemblGenomes-Gn:BSU34820" /db_xref="EnsemblGenomes-Tr:CAB15487" /db_xref="GOA:O06967" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12395" /db_xref="UniProtKB/Swiss-Prot:O06967" /translation="MPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSL LIPLLTKQLVDGFSMSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLREL LWKKLIKLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTILF IMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQILPEIRLVKA SNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIGYGGMQVSSG ELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQI ENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYS PTAGTIRLGDEPVDTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEK AAEMAYALNFIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDEATSS LDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMAS HGLYRDFAEQQLKMNADLENKAG*" /label="bmrA CDS" gene complement(2991542..2993311) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /label="bmrA gene" S_feature complement(2993312..2993386) /Source="Nicolas_S_feature" /locus_tag="new_3579515_3579589_c" /HighExp="LBGstat, Cold, Lbexp, G150, Oxctl, dia0, T1.30H, T0.30H, BC, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1329" misc_feature complement(2993375..2993394) /Source="Nicolas_upshift_promotors" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2993386) /Source="Nicolas_upshifts" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" CDS complement(2993476..2993835) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391363.1" /db_xref="EnsemblGenomes-Gn:BSU34830" /db_xref="EnsemblGenomes-Tr:CAB15488" /db_xref="SubtiList:BG14157" /db_xref="UniProtKB/Swiss-Prot:O32265" /translation="MTSLFSESETEIVSTTYMFLTQDEMKGKAGTLNQPINDFLSLTK KFESSLKEEIKGQKGLIVKKIKKELESNSEKRKAALQMIKEEHTAKVDRYKMIIEDLR QQDVTLTYRKKKPVKDV*" /label="yvzA CDS" gene complement(2993476..2993835) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /label="yvzA gene" downshifts complement(2993496) /Source="Nicolas_upshifts" /id="D1807" /incds=0 /nref=146 /ntot=246 /MaxReadThrough="2.52417" /MaxDrop="4.81771" /score="18.5636016" /energy="-13.2" /TU="NA" /idTUdmin="U2735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2993850..2995760) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391364.1" /db_xref="EnsemblGenomes-Gn:BSU34840" /db_xref="EnsemblGenomes-Tr:CAB15489" /db_xref="SubtiList:BG12394" /db_xref="UniProtKB/Swiss-Prot:O06966" /translation="MGNKNVFENENVKLRLIDLEYDYKQKFASTIASEVKKAKKDFEA DIRRIYKEETHHDLPENMKIEIYTSNELVNQNTSIQSSTRESGYDGTAIHIIDEKKHI DQLQIISEGSADNKDWSYNFFGLFLGIDHSQYEATKEFTNKAKKAAGNSEDLKTFALG HSLANNNQVMVQLIDGEYDEVYGVNGAQVNIDQLLETDESLYRYVIRKFSYKYEDIDS IPPEKLKKEIQKYYEDKGVTTNITQRISKDDPLYGVSGKADFITFGDVKMADTNTSVK GIRNIMDGVPDEDVRSIQKFLQKYKDDYEKDGLNGFIKAASGIDIDLIEKVKNTDGAL KKVSVLYEHFDDVKQMYGRIKEELPSFLGFLHTLLRNSGPVVDQLAENGYIDETQKKV IKKELTNINASMRGIESRYEHFIDHLKHGQFMQALKDVGEIVDYVKSILSSLKTLDTE TKDALKLIVDGHSIVQMLNALSKEKGFSYKGSDIYFTGKSGSGETIQVNLSSAVRIYQ NGMKIVEDMEDAISKYQKVYSQEIDEDFIDKKQAIITAIHHMEENPSHYAFDLQFRLA AGFSHTFDKLEKISVHESFHTGALPANDGIVAELKKQTTEKRDFIKNIRESIEKLFEK EEMISQLFDFQS*" /label="yvcB CDS" gene complement(2993850..2995760) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /label="yvcB gene" CDS complement(2995762..2996487) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17590234; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391365.1" /db_xref="EnsemblGenomes-Gn:BSU34850" /db_xref="EnsemblGenomes-Tr:CAB15490" /db_xref="GOA:O06965" /db_xref="SubtiList:BG12393" /db_xref="UniProtKB/Swiss-Prot:O06965" /translation="MKKIIFICFSLLLALTGGCSMNDNDKNSTNDNKTEAVKPKDMDP KDLPQVPAFQDEKTREYMVSTKEEEPGYYLLESKLKGFRMLFPEDGKYLSRRSSLTGK NKESIGFNSYDKDTNVMFDGHVTYYKEESFANEPKTMLDIVSGKNDYKGEYKKSSKKK TDIYTAKKKDIFDDIDRKYNYSYSYFGYVKSTEEDNLGVEYAFTLGCKNENQPCSLDE EKAKNKVEKLINSITFLIDKKEK*" /label="yvcA CDS" gene complement(2995762..2996487) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /label="yvcA gene" S_feature complement(2996488..2996576) /Source="Nicolas_S_feature" /locus_tag="new_3582691_3582779_c" /HighExp="T1.30H, T0.30H, T1.0H, T2.0H, T2.30H, T3.0H, T-1.40H, T-1.10H, MG 150, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1330" promotor_-10 complement(2996576..2996595) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2996576) /Source="Nicolas_upshifts" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2996578..2996707) /Source="Nicolas_S_feature" /locus_tag="new_3582781_3582910_c" /HighExp="Etha, Diami, HiTm, T1.0H, Cold, MG 15, T0.30H, BMM, T1.30H, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1331" promotor_-35 complement(2996611..2996614) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2996733..2997362) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /EC_number="3.5.4.19" /EC_number="3.6.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15871048, 17767732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase" /protein_id="NP_391366.1" /db_xref="EnsemblGenomes-Gn:BSU34860" /db_xref="EnsemblGenomes-Tr:CAB15491" /db_xref="GOA:O34912" /db_xref="InterPro:IPR002496" /db_xref="InterPro:IPR008179" /db_xref="InterPro:IPR021130" /db_xref="InterPro:IPR023019" /db_xref="InterPro:IPR026660" /db_xref="SubtiList:BG12603" /db_xref="UniProtKB/Swiss-Prot:O34912" /translation="MKQADELRFNEDGLIPAIVQDAASKEVLTLAYMNKESYEKTLET KETWFYSRSRQALWHKGETSGNTQAVKGIRYDCDQDALLVLVEPSGPACHTGSYSCFT KEQTEEQAADRFGIMNELERVIAERQAEMPEGAYTTYLFREGVDKILKKVGEEASEVI IAAKNRDHEELKWEAADLLYHLLVLLREQSLPLDDVLDVLKKRHSEIEE*" /label="hisIE CDS" gene complement(2996733..2997362) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /label="hisIE gene" downshifts complement(2996752) /Source="Nicolas_upshifts" /id="D1808" /incds=0 /nref=104 /ntot=178 /MaxReadThrough="4.37156" /MaxDrop="4.76747" /score="14.9565762" /energy="-8.4" /TU="U2738" /idTUdmin="U2735" /TUdmin="-3256" /isTUend="FALSE" /label="downshifts" CDS complement(2997359..2998117) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /EC_number="4.3.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 17767732, 19636909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase subunit" /protein_id="NP_391367.1" /db_xref="EnsemblGenomes-Gn:BSU34870" /db_xref="EnsemblGenomes-Tr:CAB15492" /db_xref="GOA:O34727" /db_xref="InterPro:IPR004651" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12600" /db_xref="UniProtKB/Swiss-Prot:O34727" /translation="MITKRIIPCLDVKEGRVVKGIQFLELKDAGDPVELAEVYDREGA DELVFLDISASHEGRKTMVDVVEQVAAKLAIPFTVGGGINQLSDMKTILRAGADKVSV NTAAVLRPELITEGAEFFGSQCIVLAIDAKYDKESDTYKVYTHGGRKKTDWEVTAWAK EGVKRGAGEILLTSMDSDGEKKGFDHTLTKLVSEAVPVPVIASGGAGNAQHMLEAFTK GEADAALAASIFHYKETSIKEVKSYLKEYGVNVR*" /label="hisF CDS" gene complement(2997359..2998117) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /label="hisF gene" CDS complement(2998114..2998851) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /EC_number="5.3.1.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 26294764; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase" /protein_id="NP_391368.1" /db_xref="EnsemblGenomes-Gn:BSU34880" /db_xref="EnsemblGenomes-Tr:CAB15493" /db_xref="GOA:O35006" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR006063" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023016" /db_xref="SubtiList:BG12597" /db_xref="UniProtKB/Swiss-Prot:O35006" /translation="MSAFTLYPAIDMRNGKCVRLVQGDYNKETIYGDSPYDMAELFEK EGAEWIHLVDLDGAKEGKRVNDRHVIEIAQKLNLKVEIGGGIRSENDVYEYLSAGVER VILGSSAVSNPPFVKKMLKQYGEKIAIGLDARNGFVSTEGWLETSTLKATELGKELAN EGAEVFIFTDIATDGMLSGPNVKSTVELAKETGKSVIASGGVSSVADLEALARNEADG VSGAIIGKALYTNQFTLSEALERVKRK*" /label="hisA CDS" gene complement(2998114..2998851) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /label="hisA gene" CDS complement(2998848..2999486) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /EC_number="2.4.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 15301532" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 15301532; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase, glutamineamidotransferase subunit" /protein_id="NP_391369.1" /db_xref="EnsemblGenomes-Gn:BSU34890" /db_xref="EnsemblGenomes-Tr:CAB15494" /db_xref="GOA:O34565" /db_xref="InterPro:IPR010139" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12602" /db_xref="UniProtKB/Swiss-Prot:O34565" /translation="MIGVIDYGMGNLYSVSKALERVGVPYFVSEKPEELKEADAFILP GVGSFGDAMDNLGYTKLDQLIHDMVSEGRLLLGICLGMQLLFEESEENGTASGLGLLK GKAVRLKAEDEKGNKLKVPHMGWNRLSFHNESPLLTKTEQGYAYFVHSYYIDGMEENA LLASADYGVRVPAVVGKRNVFGAQFHPEKSSTVGMSILTQFTKMAAEQKVKK*" /label="hisH CDS" gene complement(2998848..2999486) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /label="hisH gene" promotor_no_box 2999344..2999444 /Source="Nicolas_upshift_promotors" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2999404 /Source="Nicolas_upshifts" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2999487..3000071) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /EC_number="4.2.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 24311587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazoleglycerol-phosphate dehydratase [Mn(II)-dependent]" /protein_id="NP_391370.1" /db_xref="EnsemblGenomes-Gn:BSU34900" /db_xref="EnsemblGenomes-Tr:CAB15495" /db_xref="GOA:O34683" /db_xref="InterPro:IPR000807" /db_xref="InterPro:IPR020565" /db_xref="InterPro:IPR020568" /db_xref="SubtiList:BG12598" /db_xref="UniProtKB/Swiss-Prot:O34683" /translation="MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFT KHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVPMDEAL AQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTH HMIEAVFKALGRALDEATTIDPRVKGIPSTKGML*" /label="hisB CDS" gene complement(2999487..3000071) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /label="hisB gene" CDS complement(3000068..3001351) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /EC_number="1.1.1.23" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10353847, 10353848, 21672513, 24140957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol dehydrogenase" /protein_id="NP_391371.1" /db_xref="EnsemblGenomes-Gn:BSU34910" /db_xref="EnsemblGenomes-Tr:CAB15496" /db_xref="GOA:O34651" /db_xref="InterPro:IPR001692" /db_xref="InterPro:IPR012131" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR022695" /db_xref="SubtiList:BG12599" /db_xref="UniProtKB/Swiss-Prot:O34651" /translation="MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAV RSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQVIRQAIENIREYHERQLQSSWFY HRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDG LLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREV FGDVDIDMIAGPSEIVVLADETAIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVS AEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAPEHLEIITQSPEALL GSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQ SAFEEHAESIAAFARLEGLEAHARSIEARERRISK*" /label="hisD CDS" gene complement(3000068..3001351) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /label="hisD gene" CDS complement(3001348..3001989) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /EC_number="2.4.2.17" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 14741209, 15660995, 17154531, 21774583, 22989207, 28092443, 28872824; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP phosphoribosyltransferase" /protein_id="NP_391372.1" /db_xref="EnsemblGenomes-Gn:BSU34920" /db_xref="EnsemblGenomes-Tr:CAB15497" /db_xref="GOA:O34520" /db_xref="InterPro:IPR001348" /db_xref="InterPro:IPR013820" /db_xref="InterPro:IPR018198" /db_xref="InterPro:IPR024893" /db_xref="PDB:2VD2" /db_xref="SubtiList:BG12601" /db_xref="UniProtKB/Swiss-Prot:O34520" /translation="MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVP EENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEEERDVYEVLDLNISKCHLAVAGL PNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVST GQTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK*" /label="hisG CDS" gene complement(3001348..3001989) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /label="hisG gene" CDS complement(3001982..3003157) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /EC_number="2.4.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 15660995; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase-like subunit of ATP phophoribosyltransferase" /protein_id="NP_391373.1" /db_xref="EnsemblGenomes-Gn:BSU34930" /db_xref="EnsemblGenomes-Tr:CAB15498" /db_xref="GOA:O34459" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR004517" /db_xref="InterPro:IPR006195" /db_xref="SubtiList:BG12606" /db_xref="UniProtKB/Swiss-Prot:O34459" /translation="MFMFEKPHGMRDTLPGLYETKKKVRRSLTDLIDKWGYQFMETPT LEFYDTVGVQSAIEEQQLFKLLDQDGKTLVLRPDMTGPIARVAASKLLKHGHPLRVGY AANVFRAQEREGGRPAEFEQVGVELIGDGTTSADAEVIALVVGALKNAGLASFKIAIG HAGIADALFVEVLGNVERADVLRRFLYEKNYVGYREHVKSLPLSSIDKSRLLELLELR GGIEVCGRAEEIVDSAQGKSVVDELKALWDILEDYGCTENVRLDLNMVSHMSYYTGIL FEVYAENVGFVIGSGGRYNKLLGHFDSPAPATGFGLRIDRLIEALHMKDEPCEIDAVI FSKEQRAQAIAYANEERMKGNKVVLQDLSGIENIDQMTKSFANVTYFIGARKEEQNG* " /label="hisZ CDS" gene complement(3001982..3003157) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /label="hisZ gene" S_feature complement(3003158..3003235) /Source="Nicolas_S_feature" /locus_tag="new_3589361_3589438_c" /HighExp="Diami, M/G, Etha, BMM, MG 15, MG 10, T-1.10H, T-0.40H, T-1.40H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1332" promotor_-35 3003201..3003207 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3003219..3003238 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3003219..3003238) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3003232 /Source="Nicolas_upshifts" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3003235) /Source="Nicolas_upshifts" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3003251..3003258) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3003367..3003386 /Source="Nicolas_upshift_promotors" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3003374 /Source="Nicolas_upshifts" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="upshifts" CDS 3003408..3004160 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydratase" /protein_id="NP_391374.1" /db_xref="EnsemblGenomes-Gn:BSU34940" /db_xref="EnsemblGenomes-Tr:CAB15499" /db_xref="InterPro:IPR016997" /db_xref="SubtiList:BG14130" /db_xref="UniProtKB/Swiss-Prot:O34735" /translation="MKTLRTLCVLMILSGVIFFGLKIDAKDIDIPFLNSLKKVVSDSD TDSAANSKKELKGSAKPLDVILYNQMDAPRLYNGCEVTSLAMVLNYAGYDVTKNTLAN QVATVPLTYSSGLKGDPNDGFVGDMANGPGLGVYHRPIYQLAKTYAGDKVSDLTGKSI SAVYQQLEKGNPVWVITTANFTPVDNMQTWKTPNGTIEITYSEHSVAVTGYDDKYVYL NDPYGYKNRKTDRTSFEKAWKQMGSQAVVIQK*" /label="yvpB CDS" gene 3003408..3004160 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /label="yvpB gene" S_feature 3004161..3004399 /Source="Nicolas_S_feature" /locus_tag="new_3590364_3590602" /HighExp="LBGstat, LPhT, Cold, Sw, M/G, G180, G135, LBGtran, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1333" promotor_-10 complement(3004182..3004193) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3004188) /Source="Nicolas_upshifts" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3004208..3004214) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3004400..3005065 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658655, 15187182, 16514142, 20000851, 24236123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658655, 15187182, 16514142, 20000851, 24236123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted pectate (polygalacturonate) lyase" /protein_id="NP_391375.1" /db_xref="EnsemblGenomes-Gn:BSU34950" /db_xref="EnsemblGenomes-Tr:CAB15500" /db_xref="GOA:O34310" /db_xref="InterPro:IPR004898" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG14129" /db_xref="UniProtKB/Swiss-Prot:O34310" /translation="MKKIVSILFMFGLVMGFSQFQPSTVFAADKVVHETIIVPKNTTY DGKGQRFVAGKELGDGSQSENQDPVFRVEDGATLKNVVLGAPAADGVHTYGNVNIQNV KWEDVGEDALTVKKEGKVTIDGGSAQKASDKIFQINKASTFTVKNFTADNGGKFIRQL GGSTFHVDVIIDKCTITNMKEAIFRTDSKTSTVRMTNTRYSNVGQKWIGVQHIYENNN TQF*" /label="pelC CDS" gene 3004400..3005065 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /label="pelC gene" downshifts 3005036 /Source="Nicolas_upshifts" /id="D1809" /incds=0 /nref=85 /ntot=213 /MaxReadThrough="1.40389" /MaxDrop="4.93342" /score="16.0973385" /energy="-14.9" /TU="NA" /idTUdmin="U2739" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(3005085..3005603) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21761520, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21761520, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphorylated heptaprenylglyceryl phosphate O-acetyltransferase" /protein_id="NP_391376.1" /db_xref="EnsemblGenomes-Gn:BSU34960" /db_xref="EnsemblGenomes-Tr:CAB15501" /db_xref="GOA:O34993" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG14128" /db_xref="UniProtKB/Swiss-Prot:O34993" /translation="MRKTDRHPVSGANSLWHVYQTVPFLKVVKNFIVIQIARYTPFIG MKNWLYRTFLRMKVGKQTSFALMVMPDIMFPEKISVGTNTIIGYNTTILAHEYLIHEY RIGKVLIGDEVMIGANTTILPGVKIGDGAVVSAGTLVHKDVPDGAFVGGNPMRIIYTK EEMQERLKKSAE*" /label="hprF CDS" gene complement(3005085..3005603) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /label="hprF gene" downshifts complement(3005119) /Source="Nicolas_upshifts" /id="D1810" /incds=0 /nref=245 /ntot=283 /MaxReadThrough="1.27998" /MaxDrop="6.44997" /score="38.2106579" /energy="-14.9" /TU="NA" /idTUdmin="U2741" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3005607..3006257) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /EC_number="3.6.1.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9465101, 12359880, 12411438, 16182622, 22353596" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9465101, 12359880, 12411438, 16182622, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Hpr-associated pyrophosphatase" /protein_id="NP_391377.1" /db_xref="EnsemblGenomes-Gn:BSU34970" /db_xref="EnsemblGenomes-Tr:CAB15502" /db_xref="GOA:Q9JMQ2" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023733" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14127" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ2" /translation="MSDKQVTTILFDLDGTLINTNELIIASFLHTLEHYYPSKYKRED VLAFIGPSLFDTFSSMDPDKCEDMIAMYRAYNHDMHDSLVTEYETVYETLDALKKAGF TLGIVTTKLRDTVNMGLKLTGIGEFFETVVTLDDVTNAKPDPEPVLLALKQLGSEPAE AIMVGDNYHDVLAGKNAGTKTAGVAWTIKGPEMLAKHEPDFMLEKMSDLLQIVGVK*" /label="ppaX CDS" gene complement(3005607..3006257) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /label="ppaX gene" CDS complement(3006254..3007192) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27226549; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with nucleotide binding domain" /protein_id="NP_391378.1" /db_xref="EnsemblGenomes-Gn:BSU34980" /db_xref="EnsemblGenomes-Tr:CAB15503" /db_xref="GOA:O34382" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG14126" /db_xref="UniProtKB/Swiss-Prot:O34382" /translation="MKKIFLAGLAAGFQTTWTLGKVIFPVTLLVTLLQHTPVMDWLVR LITPVMGLFGLSGEAAIPLVLGNMLNLYAGIAGILTLDLSVKEVFILAVMLSFCHNLI IESTVAAKVGIRIGVILAVRIGLAAVSAIVINLIWHGGKETAQYGFIAAKSAAPDSWL GMLAEALTKAGLGVLQLAAIVIPLMIIIQFLRDLGWLYRFSRWLSPFTQLLGMNKNTS MTMVTGLTIGLAYGAGVMIKAVEDDGVSKRDMTLAFIFLVACHAVVEDTLVFIPLGIP VWPLLLIRVTTAVLLTMAIAHTWKKWKPSAVGKEAI*" /label="yvoD CDS" gene complement(3006254..3007192) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /label="yvoD gene" CDS complement(3007216..3008025) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /EC_number="2.4.99.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prelipoprotein diacylglycerol transferase" /protein_id="NP_391379.1" /db_xref="EnsemblGenomes-Gn:BSU34990" /db_xref="EnsemblGenomes-Tr:CAB15504" /db_xref="GOA:O34752" /db_xref="InterPro:IPR001640" /db_xref="SubtiList:BG12611" /db_xref="UniProtKB/Swiss-Prot:O34752" /translation="MNEAIEPLNPIAFQLGPLAVHWYGIIIGLGALLGLWIAMRESEK RGLQKDTFIDLVLFAIPIAIICARIYYVAFEWDYYAAHPGEIIKIWKGGIAIHGGLIG AILTGYVFSRVKNLSFWKLADIAAPSILLGQAIGRWGNFMNQEAHGEAVSRAFLENLH LPEFIINQMYINGQYYHPTFLYESLWSFVGVIVLLLLRRANLRRGEMFLIYIIWYSIG RYFIEGMRTDSLMLTDSLRIAQVISIVLIVLAVAAIIFRRVKGYSKERYAE*" /label="lgt CDS" gene complement(3007216..3008025) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /label="lgt gene" CDS complement(3008039..3008971) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /EC_number="2.7.4.-" /EC_number="2.7.11.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine protein kinase/phosphorylase (pyrophosphate-producing)" /protein_id="NP_391380.1" /db_xref="EnsemblGenomes-Gn:BSU35000" /db_xref="EnsemblGenomes-Tr:CAB15505" /db_xref="GOA:O34483" /db_xref="InterPro:IPR003755" /db_xref="InterPro:IPR011104" /db_xref="InterPro:IPR011126" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG14125" /db_xref="UniProtKB/Swiss-Prot:O34483" /translation="MAKVRTKDVMEQFNLELISGEEGINRPITMSDLSRPGIEIAGYF TYYPRERVQLLGKTELSFFEQLPEEEKKQRMDSLCTDVTPAIILSRDMPIPQELIDAS EKNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKS ETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPELIEHLLEIRGLGIINVMTLFGAG AVRSNKRITIVMNLELWEQGKQYDRLGLEEETMKIIDTEITKLTIPVRPGRNLAVIIE VAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQEE*" /label="hprK CDS" gene complement(3008039..3008971) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /label="hprK gene" promotor_-10 complement(3009013..3009032) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3009019) /Source="Nicolas_upshifts" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3009048..3009053) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3009088..3009095 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3009107 /Source="Nicolas_upshifts" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3009110..3009127 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3009153..3010343 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /EC_number="3.5.1.25" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6774970, 14557261, 21602348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6774970, 14557261, 21602348; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosamine-6-phosphate deacetylase" /protein_id="NP_391381.1" /db_xref="EnsemblGenomes-Gn:BSU35010" /db_xref="EnsemblGenomes-Tr:CAB15506" /db_xref="GOA:O34450" /db_xref="InterPro:IPR003764" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2VHL" /db_xref="SubtiList:BG12630" /db_xref="UniProtKB/Swiss-Prot:O34450" /translation="MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYS KEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQ EHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVEL FKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGA SHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKL ILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNC SWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKE ADQI*" /label="nagA CDS" gene 3009153..3010343 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /label="nagA gene" promotor_-35 3010141..3010147 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3010162 /Source="Nicolas_upshifts" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3010163..3010181 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3010340..3011068 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /EC_number="3.5.99.6" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15755726, 18436239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 18436239; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate isomerase" /protein_id="NP_391382.1" /db_xref="EnsemblGenomes-Gn:BSU35020" /db_xref="EnsemblGenomes-Tr:CAB15507" /db_xref="GOA:O35000" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="PDB:2BKV" /db_xref="PDB:2BKX" /db_xref="SubtiList:BG12631" /db_xref="UniProtKB/Swiss-Prot:O35000" /translation="MKVMECQTYEELSQIAARITADTIKEKPDAVLGLATGGTPEGTY RQLIRLHQTENLSFQNITTVNLDEYAGLSSDDPNSYHFYMNDRFFQHIDSKPSRHFIP NGNADDLEAECRRYEQLVDSLGDTDIQLLGIGRNGHIGFNEPGTSFKSRTHVVTLNEQ TRQANARYFPSIDSVPKKALTMGIQTILSSKRILLLISGKSKAEAVRKLLEGNISEDF PASALHLHSDVTVLIDREAASLRP*" /label="nagBA CDS" gene 3010340..3011068 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /label="nagBA gene" CDS 3011086..3011817 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /experiment="publication(s) with functional evidences, PMID:16207374, 20047956, 21602348, 23667565, 24673833, 26162881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 20047956, 21602348, 23667565, 24673833, 26162881; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_391383.1" /db_xref="EnsemblGenomes-Gn:BSU35030" /db_xref="EnsemblGenomes-Tr:CAB15508" /db_xref="GOA:O34817" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2WV0" /db_xref="PDB:4U0V" /db_xref="PDB:4U0W" /db_xref="PDB:4U0Y" /db_xref="PDB:4WWC" /db_xref="SubtiList:BG14124" /db_xref="UniProtKB/Swiss-Prot:O34817" /translation="MNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQF GISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGS RLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNES HFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNG TAFEHAKSVYRGDRYTFVHYMDRLS*" /label="nagR CDS" gene 3011086..3011817 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /label="nagR gene" CDS complement(3011837..3015706) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_391384.1" /db_xref="EnsemblGenomes-Gn:BSU35040" /db_xref="EnsemblGenomes-Tr:CAB15509" /db_xref="GOA:O34986" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR011401" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036415" /db_xref="SubtiList:BG14123" /db_xref="UniProtKB/Swiss-Prot:O34986" /translation="MRKYTVIASILLSFLSVLSGGHHESKAFPVVQQELFQTPHYIPL LENPPQIDVKAEMRSNLMIEAQVRDNSYQAFSAFLFYKQSNELGYKMVPMDPTPGAVR KFLAQIPKRLIWNSELEYYIVMSNGKQRVESETKKLKLEGYQADLAHIPELLITELAV DTKNIGRADGYEFIEIFNTTDRTIDFKDYHIRYRYPKEGPDSDLIWRPDERILIPSGE TFVVWLKPAGHPELTSADFNRYYQTQLKEGKNLAVIDETEGMANTRPRAVVISTNTGK DISVAHYRKHALRRLSSVLYKYPLNGTAELLNISIGEKNPSPGTVLQAQVPDQKRKIK LDKEKPVIEDLTDRKPVRPAESIELRADIRDRSLVKTVAFYYRTDENKPFKRILAEKD RNDNLFHYIVYSPELIGKDQLEYYVAAGDGINEARTPVKMIDIKQTSKAHGLRMNIEN RDTLSGTQFLKATTEGRADSIKLWIDGKKQVTEPAMEKEVYFAFDTRKTNLYFKNAVT MEGKVLKVFDDTTNKYRTYSVPLPETLLRKGKQLQRITIRSGSKVSPFDTAENRDDFL VKNARLVLSDGTVIRDQRVSPEKELFIGDNQRSNKSWQFQFNLPDGLFTSQLLEWDTS KLSEGAHHIQASDGKENVSLVVRVDNSGPHIEPNITEGQTYKGNLILQADMYDKWSRI EEAEASLDGESITLPYHTSSSDLLPGKHSLKVTATDLAGNKTVIERIFKTEREHPDQP EVIDSEADTHKAKLSVRVKDPTNDAMDVGFYRGFQYTARNHVKIFKHASLTEPPKSFV PERETPFTNKELERVSAADGKTVSTENKELFPYHRFEVTVDPSIDENDLAESVWKGSS LPGRKVTMYAWNYRTNEWQPVDSFVAKDDKPFTLKASVIAADFVRESKMNVIVQDEIP PAKDMYTFVWMSDTQYYAESYPHIFDKQTEWIKDNQKQLNIKYVFHTGDIVDDSADIR QWKNADRSMSVLDKSGIPYGVLAGNHDVGHKDGSYRAFGKYFGSDRFDKKFHYGGSYK NNRGHYDLISSNGNDYIMLYMGWGITDEDIAWMNQVLKKHPDRMAILAFHEYLLVSGN RSPIGEKIFKEIVKPNPNVVMVLSGHYHSAMRKTDELDDDGDGKPDRLVHQMLADYQG GPEGGQGYLRLLQFDQANDMVHVSTYSPYVKDKNYYDTDTYGNKDEFSLSLDLKPRIK KVETDYFECNVYTNEELGKREQVKSGDTAEFRWDHLEPQSVYYWYIIVEDSFNGKTKS PIWKFKTKKETYRPAPDQFDFRHVSNP*" /label="yvnB CDS" gene complement(3011837..3015706) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /label="yvnB gene" downshifts complement(3011959) /Source="Nicolas_upshifts" /id="D1811" /incds=1 /nref=19 /ntot=109 /MaxReadThrough="1.28942" /MaxDrop="4.39575" /score="28.0438848" /energy="-16.5" /TU="NA" /idTUdmin="U2744" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3015726..3015737) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3015733) /Source="Nicolas_upshifts" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3015752..3015758) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3015796..3015802 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3015816..3015835 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3015821 /Source="Nicolas_upshifts" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="upshifts" CDS 3015871..3016344 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391385.1" /db_xref="EnsemblGenomes-Gn:BSU35050" /db_xref="EnsemblGenomes-Tr:CAB15510" /db_xref="GOA:O34692" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14122" /db_xref="UniProtKB/Swiss-Prot:O34692" /translation="MDNSIHDELFQAIQQFALKRDKRVWQKVQIPSIGISSQHHDHLK KDWTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNK KEIFYTLTDSGRKLAALHEQLHEKAKEQYKQLFNEFSIDDLKTVTAFFNLWIKYM*" /label="yvnA CDS" gene 3015871..3016344 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /label="yvnA gene" S_feature 3016345..3016452 /Source="Nicolas_S_feature" /locus_tag="new_3602548_3602655" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, T2.30H, M9-stat, T2.0H, T1.30H, T1.0H, BC" /AntisenseName="cypX" /AntisenseCor="-1.1473096183385199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1334" CDS complement(3016385..3017602) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /EC_number="1.14.-.-" /function="16.5: Explore" /function="16.14: Store" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:4204912, 20690619, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 20690619, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclo-L-leucyl-L-leucyl dipeptide oxidase, pulcheriminic synthase" /protein_id="NP_391386.1" /db_xref="EnsemblGenomes-Gn:BSU35060" /db_xref="EnsemblGenomes-Tr:CAB15511" /db_xref="GOA:O34926" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR030904" /db_xref="InterPro:IPR036396" /db_xref="PDB:3NC3" /db_xref="PDB:3NC5" /db_xref="PDB:3NC6" /db_xref="PDB:3NC7" /db_xref="SubtiList:BG12580" /db_xref="UniProtKB/Swiss-Prot:O34926" /translation="MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFIS RYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALD HLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSG VADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMAL SDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRY KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK SAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYT RGPVSLLVAFDGA*" /label="cypX CDS" gene complement(3016385..3017602) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /label="cypX gene" downshifts complement(3016398) /Source="Nicolas_upshifts" /id="D1812" /incds=0 /nref=11 /ntot=50 /MaxReadThrough="2.27112" /MaxDrop="6.67384" /score="-0.264310319" /energy="-11.6" /TU="NA" /idTUdmin="U2747" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3016424..3016429 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3016444..3016455 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3016454..3016739 /Source="Nicolas_S_feature" /locus_tag="new_3602657_3602942" /HighExp="BC, Sw, Lbstat, T5.0H, M9-stat, T4.0H, T3.30H, B60, T1.30H, T0.30H" /AntisenseName="cypX" /AntisenseCor="-4.04991056466339E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.438, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1335" upshifts 3016454 /Source="Nicolas_upshifts" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="upshifts" downshifts 3016696 /Source="Nicolas_upshifts" /id="D1813" /incds=1 /nref=9 /ntot=165 /MaxReadThrough="3.27492" /MaxDrop="3.99509" /score="54.0406126" /energy="-11.4" /TU="U2745,U2746" /idTUdmin="U2746" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3017618..3018364) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /EC_number="6.-.-.-" /function="16.14: Store" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:4204912, 19430487, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 19430487, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclodipeptide synthase (tRNA-dependent), pulcherimminic acid precursor" /protein_id="NP_391387.1" /db_xref="EnsemblGenomes-Gn:BSU35070" /db_xref="EnsemblGenomes-Tr:CAB15512" /db_xref="GOA:O34351" /db_xref="InterPro:IPR030903" /db_xref="SubtiList:BG14121" /db_xref="UniProtKB/Swiss-Prot:O34351" /translation="MTGMVTERRSVHFIAEALTENCREIFERRRHVLVGISPFNSRFS EDYIYRLIGWAKAQFKSVSVLLAGHEAANLLEALGTPRGKAERKVRKEVSRNRRFAER ALVAHGGDPKAIHTFSDFIDNKAYQLLRQEVEHAFFEQPHFRHACLDMSREAIIGRAR GVSLMMEEVSEDMLNLAVEYVIAELPFFIGAPDILEVEETLLAYHRPWKLGEKISNHE FSICMRPNQGYLIVQEMAQMLSEKRITSEG*" /label="pchC CDS" gene complement(3017618..3018364) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /label="pchC gene" S_feature complement(3018365..3018551) /Source="Nicolas_S_feature" /locus_tag="new_3604568_3604754_c" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T3.0H, T1.0H, B36, BT, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1336" promotor_-10 complement(3018537..3018556) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3018551) /Source="Nicolas_upshifts" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3018570..3018577) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3018685..3018692 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3018707..3018726 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3018719 /Source="Nicolas_upshifts" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="upshifts" S_feature 3018720..3018789 /Source="Nicolas_S_feature" /locus_tag="new_3604923_3604992" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T1.0H, T0.30H, B36, T3.0H, BT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1337" CDS 3018790..3019299 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27542896; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for pulcherriminic acid synthesis" /protein_id="NP_391388.1" /db_xref="EnsemblGenomes-Gn:BSU35080" /db_xref="EnsemblGenomes-Tr:CAB15513" /db_xref="GOA:P40762" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11018" /db_xref="UniProtKB/Swiss-Prot:P40762" /translation="MSDLTKQMIYDIYVRLLHLNEQKANTSLQQFFKEAAEEDVAEIP KNMTSIHVIDCIGQHEPINNAGIARKMNLSKANVTKISTKLIKEEFINSYQLTDNKKE VYFKLTRKGRRIFDLHEKLHKKKELAFYQFLDSFSQEEQKAVLKFLEQLTSTLEAEQT DGTPDKPVK*" /label="pchR CDS" gene 3018790..3019299 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /label="pchR gene" S_feature complement(3019195..3020533) /Source="Nicolas_S_feature" /locus_tag="new_3605398_3606736_c" /HighExp="T0.30H, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, G135, T2.30H, T-1.10H, G180" /AntisenseName="yvmA" /AntisenseCor="0.2423954904641" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1338" downshifts complement(3019236) /Source="Nicolas_upshifts" /id="D1814" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.42525" /MaxDrop="2.72496" /score="14.1278884" /energy="-7.8" /TU="NA" /idTUdmin="U2749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3019320..3020531 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27542896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pulcherriminic acid efflux transporter" /protein_id="NP_391389.1" /db_xref="EnsemblGenomes-Gn:BSU35090" /db_xref="EnsemblGenomes-Tr:CAB15514" /db_xref="GOA:O34307" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14120" /db_xref="UniProtKB/Swiss-Prot:O34307" /translation="MAHTKSKAVLILYTVCFSAFFASLSQNIYSPILPIIKESFHVST AMVNLSVSVFMIVTAIMQIILGAIIDFKGARIVLITGILATAAASIGCAVTTDFTLFL IFRMIQAAGSAALPLIAATTIGQLFTGNERGSAMGTYQMLLSVAPAIAPVLGGFIGGA AGYEGIFWILAAISIVLLVTNSITFPKDSPTESMQQAKGNVFAHYKSIFTNRTGNVIL TLSFVLFFIYFAVIVYLPILLTEHYHIDVGIAGLLYLPLALSTIAGTFLFKRIQAKIG LHTLFIGSNVIAACSIILFAVTHSVSLVLMALTLALFGISMGVIPPLYSTMITNEFEH NRGSAIGMFNFIRYTGMAAGPMVSAYLLTMMPSAMSFSLLGLGFAALSFCLLPPMFSP QKRTKQKKHHM*" /label="pchE CDS" gene 3019320..3020531 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /label="pchE gene" downshifts 3020529 /Source="Nicolas_upshifts" /id="D1815" /incds=0 /nref=33 /ntot=196 /MaxReadThrough="5.27186" /MaxDrop="4.73361" /score="54.0406126" /energy="-11.4" /TU="U2748" /idTUdmin="U2748" /TUdmin="-721" /isTUend="FALSE" /label="downshifts" CDS complement(3020559..3020918) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26296725; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral phage holin-like membrane protein" /protein_id="NP_391390.1" /db_xref="EnsemblGenomes-Gn:BSU35100" /db_xref="EnsemblGenomes-Tr:CAB15515" /db_xref="GOA:O34648" /db_xref="InterPro:IPR007165" /db_xref="SubtiList:BG14119" /db_xref="UniProtKB/Swiss-Prot:O34648" /translation="MVKWAVSILVNALLLIVIDGYIDSIHISSIGAAIIASLILSILN VLIKPLLIIFTLPVTMVTLGLFLFVINAITLMMTASIMGDSFQIDGFGTAIWASVILS VFHLLIQKGILEPLRKK*" /label="yvlD CDS" gene complement(3020559..3020918) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /label="yvlD gene" S_feature 3020574..3021290 /Source="Nicolas_S_feature" /locus_tag="new_3606777_3607493" /HighExp="LBGstat, S8, Gly, C30, G135, S7, C90, Sw, Fru, S6" /AntisenseName="yvlC" /AntisenseCor="0.178445666283919" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1339" downshifts complement(3020578) /Source="Nicolas_upshifts" /id="D1816" /incds=0 /nref=129 /ntot=265 /MaxReadThrough="4.63835" /MaxDrop="5.15146" /score="14.4434545" /energy="-9.6" /TU="U2749" /idTUdmin="U2751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3020920..3021117) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23980836; Product type r : regulator" /codon_start=1 /transl_table=11 /product="membrane associated phage-like stress regulator,nisin resistance" /protein_id="NP_391391.1" /db_xref="EnsemblGenomes-Gn:BSU35110" /db_xref="EnsemblGenomes-Tr:CAB15516" /db_xref="GOA:O34719" /db_xref="InterPro:IPR007168" /db_xref="SubtiList:BG14118" /db_xref="UniProtKB/Swiss-Prot:O34719" /translation="MNKLYRSEKNKKIAGVIGGLAEYFNWDASLLRVITVILAIMTSV LPVLLIYIIWIFIVPSERDMK*" /label="yvlC CDS" gene complement(3020920..3021117) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /label="yvlC gene" CDS complement(3021122..3022219) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function, stress-related" /protein_id="NP_391392.1" /db_xref="EnsemblGenomes-Gn:BSU35120" /db_xref="EnsemblGenomes-Tr:CAB15517" /db_xref="InterPro:IPR016599" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14117" /db_xref="UniProtKB/Swiss-Prot:O34628" /translation="MKQEKERILKLVEEGKLTAQEALTLIEKLDSDYKEKEEKITALS VHVHDEEEPFTTAKKESGKPSLGAKLFDWIDSAVKKVKEVDLDLNFGHAYDVQHIFQF KDTDFSSVELQIANGSVNIVPWEDDDIRAECQAKVYRADSQDAARHAFLQHIECEIKG NKFFIRTEKKTMKTNVTLYIPQKEYDKIRVKLFNGPVRGEHLHVKEFSAKTTNGVLSF SYLTAEKAIAETANGQIKLASHSCGTIEAETINGLIDLRGKSESIDVQSFNGNIAINV TESDCRSIYAKTTTGNVELAIPDDLAVKAELKSNLGTLSHELMDVEMLKEKNDTIQKE MMFTSNQAHDQNITVFSESLTGAIKLKYSQR*" /label="yvlB CDS" gene complement(3021122..3022219) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /label="yvlB gene" CDS complement(3022244..3022570) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391393.1" /db_xref="EnsemblGenomes-Gn:BSU35130" /db_xref="EnsemblGenomes-Tr:CAB15518" /db_xref="GOA:O34322" /db_xref="SubtiList:BG14116" /db_xref="UniProtKB/Swiss-Prot:O34322" /translation="MNRNQAIIASLCYFSVFIAPIIVPIVAYFVVNEKETKRHAIRSL ISHIVPFVGWLFLFIALLGGAVAIDGDSLLPVFVIIGGAVIYFLVVIGIIIWNVIQGI KVLRAA*" /label="yvlA CDS" gene complement(3022244..3022570) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /label="yvlA gene" promotor_-10 complement(3022623..3022638) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3022638) /Source="Nicolas_upshifts" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3022640..3023130) /Source="Nicolas_S_feature" /locus_tag="new_3608843_3609333_c" /HighExp="H2O2, G180, Paraq, G150, G135, dia15, Oxctl, Diami, Lbexp, LBGexp" /AntisenseName="yvkN" /AntisenseCor="0.37678416921083902" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1340" promotor_-35 complement(3022650..3022659) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3022718..3022721 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3022736..3022755 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3022746 /Source="Nicolas_upshifts" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="upshifts" CDS 3022788..3023018 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391394.1" /db_xref="EnsemblGenomes-Gn:BSU35140" /db_xref="EnsemblGenomes-Tr:CAB15519" /db_xref="SubtiList:BG14115" /db_xref="UniProtKB/Swiss-Prot:O34604" /translation="MEKDPSDYTVTQESVLKLIQEQKRMNREMITELEQIHGPFPISH DIQYIKVLLDSSNTHIVQDLMSVSKQLYKKTL*" /label="yvkN CDS" gene 3022788..3023018 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /label="yvkN gene" promotor_-10 complement(3023121..3023140) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-10" upshifts complement(3023131) /Source="Nicolas_upshifts" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="upshifts" promotor_-35 complement(3023156..3023160) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-35" CDS complement(3023217..3023699) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16936039; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="putative flagellin" /db_xref="EnsemblGenomes-Gn:BSU35150" /db_xref="EnsemblGenomes-Tr:CAB15520" /db_xref="GOA:O34366" /db_xref="InterPro:IPR001029" /db_xref="PSEUDO:CAB15520.1" /db_xref="SubtiList:BG14158" /db_xref="UniProtKB/Swiss-Prot:O34366" /translation="MDALIEEVDGISNRTEFNGKKLLDGTETDGFTFQIGANAGQQLT VNIDSMSSTALGVNALNVTDFANTPFDTQLESIDTAINNVSNQRAKLGAVQNRLEHTI NNLGASSENLTAAESRIRDVDMAKEMSEFTKNNIPSQASQAMLAQANQQPQNVLQLLR *" /label="yvzB CDS" gene complement(3023217..3023699) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /pseudo /label="yvzB gene" downshifts 3023225 /Source="Nicolas_upshifts" /id="D1817" /incds=0 /nref=13 /ntot=113 /MaxReadThrough="0.9814" /MaxDrop="4.76969" /score="2.6592903" /energy="-5.7" /TU="NA" /idTUdmin="U2750" /TUdmin=17 /isTUend="TRUE" /label="downshifts" downshifts complement(3023240) /Source="Nicolas_upshifts" /id="D1818" /incds=0 /nref=118 /ntot=206 /MaxReadThrough="2.62918" /MaxDrop="8.97968" /score="25.6132739" /energy="-19.8" /TU="NA" /idTUdmin="U2752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3023372) /Source="Nicolas_upshifts" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3023380..3023383) /Source="Nicolas_upshift_promotors" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3023460..3023464) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3023460) /Source="Nicolas_upshifts" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3023480..3023483) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3023700..3023833) /Source="Nicolas_S_feature" /locus_tag="new_3609903_3610036_c" /HighExp="H2O2, Sw, M40t45, M40t90, Diami, Salt, dia15, BC, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1341" CDS complement(3023861..3026734) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit A)" /protein_id="NP_391396.1" /db_xref="EnsemblGenomes-Gn:BSU35160" /db_xref="EnsemblGenomes-Tr:CAB15533" /db_xref="GOA:O34863" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004602" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12697" /db_xref="UniProtKB/Swiss-Prot:O34863" /translation="MAMDRIEVKGARAHNLKNIDVTIPRDQLVVVTGLSGSGKSSLAF DTIYAEGQRRYVESLSAYARQFLGQMDKPDVDAIEGLSPAISIDQKTTSRNPRSTVGT VTEIYDYLRLLYARVGKPHCPEHGIEITSQTIEQMVDRILEYPERTKLQVLAPIVSGR KGAHVKVLEQIRKQGYVRVRIDGEMAELSDDIELEKNKKHSIEVVIDRIVVKEGVAAR LSDSLETALRLGEGRVMIDVIGEEELMFSEHHACPHCGFSIGELEPRLFSFNSPFGAC PTCDGLGMKLEVDADLVIPNQDLSLKENAVAPWTPISSQYYPQLLEAVCTHYGIDMDV PVKDLPKHQLDKVLYGSGDDLIYFRYENDFGQIREGEIQFEGVLRNIERRYKETGSDF IREQMEQYMSQKSCPTCKGYRLKKEALAVLIDGRHIGKITELSVADALAFFKDLTLSE KDMQIANLILREIVERLSFLDKVGLDYLTLSRAAGTLSGGEAQRIRLATQIGSRLSGV LYILDEPSIGLHQRDNDRLISALKNMRDLGNTLIVVEHDEDTMMAADYLIDIGPGAGI HGGQVISAGTPEEVMEDPNSLTGSYLSGKKFIPLPPERRKPDGRYIEIKGASENNLKK VNAKFPLGTFTAVTGVSGSGKSTLVNEILHKALAQKLHKAKAKPGSHKEIKGLDHLDK VIDIDQAPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKVRGYKKGRFSFNVKGGRCEA CRGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVTYKGKSISDVLDMTVEDALSFF ENIPKIKRKLQTLYDVGLGYITLGQPATTLSGGEAQRVKLASELHKRSTGRTLYILDE PTTGLHVDDIARLLVVLQRLVDNGDTVLVIEHNLDIIKTADYIVDLGPEGGAGGGTIV ASGTPEEITEVEESYTGRYLKPVIERDKTRMKSLLKAKETATS*" /label="uvrA CDS" gene complement(3023861..3026734) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /label="uvrA gene" downshifts complement(3023878) /Source="Nicolas_upshifts" /id="D1819" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="4.46283" /MaxDrop="5.3695" /score="12.0157254" /energy="-18.6" /TU="U2754,U2756" /idTUdmin="U2755" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3026742..3028727) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit B)" /protein_id="NP_391397.1" /db_xref="EnsemblGenomes-Gn:BSU35170" /db_xref="EnsemblGenomes-Tr:CAB15534" /db_xref="GOA:P37954" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004807" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR024759" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036876" /db_xref="PDB:2D7D" /db_xref="PDB:2NMV" /db_xref="PDB:3V4R" /db_xref="SubtiList:BG10502" /db_xref="UniProtKB/Swiss-Prot:P37954" /translation="MKDRFELVSKYQPQGDQPKAIEKLVKGIQEGKKHQTLLGATGTG KTFTVSNLIKEVNKPTLVIAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYV PQTDTFIEKDASINDEIDKLRHSATSALFERRDVIIIASVSCIYGLGSPEEYREMVVS LRTEMEIERNELLRKLVDIQYARNDIDFQRGTFRVRGDVVEIFPASRDEHCVRVEFFG DEIERIREVDALTGEILGDRDHVAIFPASHFVTRAEKMEKAIQNIEKELEEQLKVMHE NGKLLEAQRLEQRTRYDLEMMREMGFCSGIENYSRHLTLRPPGSTPYTLLDYFPDDFM IVVDESHVTIPQVRGMFNGDQARKQVLVDHGFRLPSALDNRPLRFEEFEKHMHNIVYV SATPGPYEIEHTDEMVEQIIRPTGLLDPLIDVRPIEGQIDDLIGEIQARIERNERVLV TTLTKKMSEDLTDYLKEIGIKVNYLHSEIKTLERIEIIRDLRLGKYDVLVGINLLREG LDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNAEGRVIMYADKITKSMEIAINE TKRRREQQERFNEEHGITPKTINKEIRDVIRATVAAEDKAEYKTKAAPKLSKMTKKER QKVVEQMEHEMKEAAKALDFERAAELRDLLLELKAEG*" /label="uvrB CDS" gene complement(3026742..3028727) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /label="uvrB gene" promotor_-10 complement(3028761..3028780) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3028773) /Source="Nicolas_upshifts" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3028775..3028860) /Source="Nicolas_S_feature" /locus_tag="new_3614978_3615063_c" /HighExp="Gly, Sw, B60, BT, LoTm, Salt, Etha, M9-stat, B36, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1342" promotor_-35 complement(3028792..3028799) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3028905) /Source="Nicolas_upshifts" /id="D1820" /incds=0 /nref=4 /ntot=60 /MaxReadThrough="5.68784" /MaxDrop="3.17938" /score="11.285993" /energy="-12" /TU="U2755,U2756" /idTUdmin="U2755" /TUdmin="-5027" /isTUend="FALSE" /label="downshifts" CDS complement(3028913..3029143) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 1592822, 1744042; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_391398.1" /db_xref="EnsemblGenomes-Gn:BSU35180" /db_xref="EnsemblGenomes-Tr:CAB15535" /db_xref="GOA:P37953" /db_xref="InterPro:IPR019242" /db_xref="SubtiList:BG10501" /db_xref="UniProtKB/Swiss-Prot:P37953" /translation="MITKAVFALFFPFMLVVLFTRVTFNHYVAIALTAALLFASYLKG YTETYFIVGLDVVSLVAGGLYMAKKAAEKKEE*" /label="csbA CDS" gene complement(3028913..3029143) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /label="csbA gene" promotor_-10 complement(3029170..3029189) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-10" upshifts complement(3029180) /Source="Nicolas_upshifts" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="upshifts" S_feature complement(3029182..3029246) /Source="Nicolas_S_feature" /locus_tag="new_3615385_3615449_c" /HighExp="Gly, M9-stat, B60, Sw, Etha, LoTm, BT, B36, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1343" promotor_-35 complement(3029203..3029210) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-35" promotor_-10 complement(3029223..3029241) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3029244) /Source="Nicolas_upshifts" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3029256..3029262) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3029312) /Source="Nicolas_upshifts" /id="D1821" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.9693" /MaxDrop="4.37808" /score="-1.92287727" /energy="-4.2" /TU="NA" /idTUdmin="U2761" /TUdmin=4752 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(3029338..3029438) /Source="Nicolas_upshift_promotors" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3029378) /Source="Nicolas_upshifts" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3029460..3029467 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3029481..3029500 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3029498 /Source="Nicolas_upshifts" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3029590..3032085 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /EC_number="2.7.-.-" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25012659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_391399.1" /db_xref="EnsemblGenomes-Gn:BSU35190" /db_xref="EnsemblGenomes-Tr:CAB15536" /db_xref="GOA:O34796" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG14114" /db_xref="UniProtKB/Swiss-Prot:O34796" /translation="MYSVLFRQAEESSQLAGAKGMNLIKLTKHGLPVPDGFIIQTNAL ARFMEDNQLQETSENVEGGIISGTFSDELKDELTSSFYKLRESYRSVAVRSSSASEDL EGASFAGQYETYLNIKTEEEFLAKVKECWASFFSGRVSSYKKKMNNQIAEPLMGIVVQ GLIDSEMSGVIFSRNPVTHDDRELLISASYGLGEAVVSGNVTPDTFIVNKSSFEIQKE IGAKEIYMESAAEGIAEKETSEDMRSRFCLTDEQVIELAEITKKTEDLYGYPVDIEFG IADHQIYLLQARPITTIDQDKKAAEEKRSFMITDTDMNDFWLNMESNIEGPVSPLFSS FIVPALEYGLKKSMQKFPIGVVVDEVKLYRGHIYSKNQGGQQPPSEDCGKELFPILSE HMYDIINHTYLPFYRTLDQLAQTEHTAESALEAFQKLKAFYLTAYEEHFNIVFPQILL TNKLQAMYQDIQGESENAHFYEMLTGKMNKSLETDRCLWLFSVEVQENPNLLAIFENN KPEQLQEKLEQTDEGRHFLKNVHEFLQEYGWRSVKSHDLIEQIWVENPYFALANIQNY VRNGYHFDNEFQKTKEKREKLYNEFLESIEDPGLRTEFDRYYQWTLNSANIKDDHHFY IDAMLDAKARIFLLKIGELLAENGVIQDREDLWFLYDDEVEQALLHPVSLQEKAEKRR QIFHEYELAQAPAYLGTPTKEQLKAAEEIVGAVIEDEKNTENHIFGIAASSGIATGPV KIIRDANEFSQFAPGDVLVCKMTTPLWTSLFQDAKAIITDTGGILSHAAIIAREYGIP AVLGTRTATERLRDGDIITVDGSSGKITVVSRS*" /label="yvkC CDS" gene 3029590..3032085 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /label="yvkC gene" misc_feature 3032100..3032104 /Source="Nicolas_upshift_promotors" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3032118 /Source="Nicolas_upshifts" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="upshifts" CDS 3032161..3032730 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391400.1" /db_xref="EnsemblGenomes-Gn:BSU35200" /db_xref="EnsemblGenomes-Tr:CAB15537" /db_xref="GOA:O34643" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG14113" /db_xref="UniProtKB/Swiss-Prot:O34643" /translation="MRPTNKRILDAAMQLLVKKGYRATTTKEIAEKANVSEATIFRNF KNKQGLVEALLSQHSSNRGSILEQTEGDLYKDLLHIGTCLLEELEHRKDIIKISFREP AMFQDVINHVTEYPQSMKQLLVDYLKTMGEKGVIQTGNEAEHADVFMSIIFGYFIHRL HLGDRVISMPQEKMLEHSTALFVKGISAD*" /label="yvkB CDS" gene 3032161..3032730 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /label="yvkB gene" CDS 3032761..3034095 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391401.1" /db_xref="EnsemblGenomes-Gn:BSU35210" /db_xref="EnsemblGenomes-Tr:CAB15538" /db_xref="GOA:O34502" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14112" /db_xref="UniProtKB/Swiss-Prot:O34502" /translation="MSSRKEWALIVSLLLGAILVPINSTMIAVALSSISHTYNESIAS ITWVVTVYLIVMAVTQPIAGKLGDMYGNKTMYLWGVGLFLIASLGCALSPSLLLLIVF RALQAVGGALLTPNSIAIIRHVVSEKRLPKVFGFFGLGAGLGAALGPFIGSILIDSFS WHSIFWVNIPFLAIALFTALTMFPQYKENKSDAPLDIIGSLLLAGSIVSIILLTKNEA PWGYTVYSVLILLFVPLFFRREKRTQHPIIDFALFKSSTFTNANLSVLLSNLMMYAVL LIMPLFMTNQFGLNTSNSGMALSVFSIFMSASNWVGAQLHHKWGAKKIIFLSFAMMAG ANLLFLLLSSSHSVLFLMLSLILGGLASGVGLTSMQVSSLATVDPGMSGVASGIFSTF RYFGSIISSALIGLISGYHTLFMILFAVSIIGVFVSLGIKSDETARIEKNSA*" /label="yvkA CDS" gene 3032761..3034095 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /label="yvkA gene" downshifts 3034076 /Source="Nicolas_upshifts" /id="D1822" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="0.94661" /MaxDrop="3.57731" /score="21.0606505" /energy="-28.8" /TU="NA" /idTUdmin="U2759" /TUdmin=1276 /isTUend="FALSE" /label="downshifts" CDS complement(3034143..3035336) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16030230, 16850406, 18976281, 19019154, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16030230, 16850406, 18976281, 19019154, 26735940; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="topological determinant of cell division" /protein_id="NP_391402.1" /db_xref="EnsemblGenomes-Gn:BSU35220" /db_xref="EnsemblGenomes-Tr:CAB15539" /db_xref="GOA:O34375" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14111" /db_xref="UniProtKB/Swiss-Prot:O34375" /translation="MSVQWGIELLKSAGLFFLHPLFWFFIIITLAFGYVRIKRERKTF HTRIADIYDDLKFTYTKGLIPGLLLSVILGGLGISIPLGLLAIIAVITAAAAFTLRAN WMSAAYIVSVSMLIGFGLQIYQAEPFLERFPQGFAVVWPAVAVFLGLLIITEGAVAYR SAHVRTSPALVVSSRGLPIGQQLANRVWLLPLFLLVPGNGLESHLSWWPVFTVPGGSF HFLWIPYFVGFGQRVQGSLPETSIRITAKRVCILGLAVAVLGAASLLWTPLAGAAVCT ALLGRIFLSIKQRVNDNAAPFYFSKRDQGLMVLGIIPNTPAEDLELKIGEIITKVNGI PVKNVSDFYEALQHNRAYVKLEIIGLNGEIRFDQRASYEGEHHELGILFVKDDREDEA VASGS*" /label="minJ CDS" gene complement(3034143..3035336) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /label="minJ gene" downshifts complement(3034152) /Source="Nicolas_upshifts" /id="D1823" /incds=0 /nref=3 /ntot=85 /MaxReadThrough="3.18641" /MaxDrop="3.13207" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=66 /isTUend="FALSE" /label="downshifts" downshifts complement(3034217) /Source="Nicolas_upshifts" /id="D1824" /incds=1 /nref=94 /ntot=239 /MaxReadThrough="4.11808" /MaxDrop="4.31508" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(3035337..3035414) /Source="Nicolas_S_feature" /locus_tag="new_3621540_3621617_c" /HighExp="LBGstat, Lbstat, M0t90, Cold, M/G, GM 10, GM 25, GM 15, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1344" downshifts complement(3035340) /Source="Nicolas_upshifts" /id="D1825" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="6.36185" /MaxDrop="3.35962" /score="-9.46264764" /energy="-7.1" /TU="U2760,U2761,U2762" /idTUdmin="U2762" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(3035415..3035753) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16030230" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16030230; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein fragment; C-terminal part of swrAA" /db_xref="GOA:O32266" /db_xref="InterPro:IPR035388" /db_xref="PSEUDO:CAB15540.1" /db_xref="SubtiList:BG14160" /db_xref="UniProtKB/Swiss-Prot:O32266" /translation="MCVKKKYYELVEQLKDRTQDVTFSATKALSLLMLFSRYLVNYTN VESVNDINEECAKHYFNYLMKNHKRLGINLTDIKRSMHLISGLLDVDVNHYLKDFSLS NVTLWMTQER*" /label="swrAAc CDS" gene complement(3035415..3035753) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /pseudo /label="swrAAc gene" CDS complement(3035728..3035844) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein; N-terminal part of swrAA" /db_xref="PSEUDO:CAX52697.1" /translation="MLVSTPVLLLILARAYLYKENGGSQLKRASIVREKKIL*" /label="swrAAn CDS" gene complement(3035728..3035844) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /pseudo /label="swrAAn gene" S_feature complement(3035845..3035934) /Source="Nicolas_S_feature" /locus_tag="new_3622048_3622137_c" /HighExp="LBGstat, M0t90, Cold, Lbstat, GM 25, Gly, nit, GM 15, GM 10, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1345" promotor_-10 complement(3035916..3035934) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3035934) /Source="Nicolas_upshifts" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3035936..3036016) /Source="Nicolas_S_feature" /locus_tag="new_3622139_3622219_c" /HighExp="LBGstat, Lbstat, Cold, M0t90, GM 25, nit, Gly, M/G, MG 150, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigGF" /TUshortPSig="0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1346" promotor_-35 complement(3035948..3035953) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3036002..3036020) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3036016) /Source="Nicolas_upshifts" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3036034..3036041) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3036153..3037595) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14526016, 17557826, 27342562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526016, 17557826, 27342562; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="PDZ-containing carboxyl-terminal protease processing protease [Zn(II)]" /protein_id="NP_391404.1" /db_xref="EnsemblGenomes-Gn:BSU35240" /db_xref="EnsemblGenomes-Tr:CAB15541" /db_xref="GOA:O35002" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="PDB:4C2C" /db_xref="PDB:4C2D" /db_xref="PDB:4C2E" /db_xref="PDB:4C2F" /db_xref="PDB:4C2G" /db_xref="PDB:4C2H" /db_xref="SubtiList:BG14110" /db_xref="UniProtKB/Swiss-Prot:O35002" /translation="MNQKIMAVIAAGSMLFGGAGVYAGINLLEMDKPQTAAVPATAQA DSERDKAMDKIEKAYELISNEYVEKVDREKLLEGAIQGMLSTLNDPYSVYMDKQTAKQ FSDSLDSSFEGIGAEVGMEDGKIIIVSPFKKSPAEKAGLKPNDEIISINGESMAGKDL NHAVLKIRGKKGSSVSMKIQRPGTKKQLSFRIKRAEIPLETVFASEKKVQGHSVGYIA ISTFSEHTAEDFAKALRELEKKEIEGLVIDVRGNPGGYLQSVEEILKHFVTKDQPYIQ IAERNGDKKRYFSTLTHKKAYPVNVITDKGSASASEILAGALKEAGHYDVVGDTSFGK GTVQQAVPMGDGSNIKLTLYKWLTPNGNWIHKKGIEPTIAIKQPDYFSAGPLQLKEPL KVDMNNEDVKHAQVLLKGLSFDPGREDGYFSKDMKKAVMAFQDQNKLNKTGVIDTRTA ETLNQQIEKKKSDEKNDLQLQTALKSLFVN*" /label="ctpB CDS" gene complement(3036153..3037595) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /label="ctpB gene" downshifts complement(3036242) /Source="Nicolas_upshifts" /id="D1826" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="3.56833" /MaxDrop="3.1636" /score="0.562448109" /energy="-11.6" /TU="U2762" /idTUdmin="U2762" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3037641..3037652) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3037652) /Source="Nicolas_upshifts" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3037667..3037673) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3037735..3038625) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 23855774, 23869552" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 23855774, 23869552; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-division ABC transporter" /protein_id="NP_391405.1" /db_xref="EnsemblGenomes-Gn:BSU35250" /db_xref="EnsemblGenomes-Tr:CAB15542" /db_xref="GOA:O34876" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR004513" /db_xref="SubtiList:BG12591" /db_xref="UniProtKB/Swiss-Prot:O34876" /translation="MIKILGRHLRESFKSLGRNTWMTFASISAVTVTLILVGVFLVIM LNLNNMATNAEKQVEIKVLIDLTADQKAQDKLQNDIKELKGIQSVTFSSKEKELDQLV DSFGDSGKSLTMKDQENPLNDAFVVKTTDPHDTPNVAKKIEKMDHVYKVTYGKEEVSR LFKVVGVSRNIGIALIIGLVFTAMFLISNTIKITIFARRKEIEIMKLVGATNWFIRWP FFLEGLLLGVFGSVIPIALVLSTYQYVIGWVVPKVQGSFVSLLPYNPFVFQVSLVLIA IGAVIGVWGSLTSIRKFLRV*" /label="ftsX CDS" gene complement(3037735..3038625) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /label="ftsX gene" downshifts complement(3037752) /Source="Nicolas_upshifts" /id="D1827" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="3.3693" /MaxDrop="6.15417" /score="15.3496791" /energy="-14.6" /TU="U2763" /idTUdmin="U2763" /TUdmin="-102" /isTUend="FALSE" /label="downshifts" CDS complement(3038618..3039304) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division signal transducer (ATP-binding protein)" /protein_id="NP_391406.1" /db_xref="EnsemblGenomes-Gn:BSU35260" /db_xref="EnsemblGenomes-Tr:CAB15543" /db_xref="GOA:O34814" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005286" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12590" /db_xref="UniProtKB/Swiss-Prot:O34814" /translation="MIEMKEVYKAYPNGVKALNGISVTIHPGEFVYVVGPSGAGKSTF IKMIYREEKPTKGQILINHKDLATIKEKEIPFVRRKIGVVFQDFKLLPKLTVFENVAF ALEVIGEQPSVIKKRVLEVLDLVQLKHKARQFPDQLSGGEQQRVSIARSIVNNPDVVI ADEPTGNLDPDTSWEVMKTLEEINNRGTTVVMATHNKEIVNTMKKRVIAIEDGIIVRD ESRGEYGSYD*" /label="ftsE CDS" gene complement(3038618..3039304) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /label="ftsE gene" S_feature complement(3039305..3039437) /Source="Nicolas_S_feature" /locus_tag="new_3625508_3625640_c" /HighExp="Cold, UNK1, MG-0.2, MG 15, MG-0.1, C30, MG 25, MG 10, M9-exp, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.998" /label="S1347" promotor_-10 complement(3039427..3039446) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3039437) /Source="Nicolas_upshifts" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3039461..3039464) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3039538..3039876) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10473570, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10473570, 19222757; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome c551" /protein_id="NP_391407.1" /db_xref="EnsemblGenomes-Gn:BSU35270" /db_xref="EnsemblGenomes-Tr:CAB15544" /db_xref="GOA:O34594" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG12574" /db_xref="UniProtKB/Swiss-Prot:O34594" /translation="MKSKLSILMIGFALSVLLAACGSNDAKEEKTDTGSKTEATASEG EELYQQSCVGCHGKDLEGVSGPNLQEVGGKYDEHKIESIIKNGRGNMPKGLVDDNEAA VIAKWLSEKK*" /label="cccB CDS" gene complement(3039538..3039876) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /label="cccB gene" downshifts complement(3039539) /Source="Nicolas_upshifts" /id="D1828" /incds=0 /nref=192 /ntot=265 /MaxReadThrough="3.58546" /MaxDrop="6.88513" /score="18.0901387" /energy="-16.8" /TU="U2764" /idTUdmin="U2765" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3039903..3039922) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3039916) /Source="Nicolas_upshifts" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" CDS complement(3039925..3040809) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10473570, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391408.2" /db_xref="EnsemblGenomes-Gn:BSU35280" /db_xref="EnsemblGenomes-Tr:CAB15545" /db_xref="GOA:O34792" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG14109" /db_xref="UniProtKB/Swiss-Prot:O34792" /translation="MLSESIGRNGGYMMDVRNKTLWILRDYVYILIGAAITAVSFNVF LLPNKIAAGGVSGISTILQSYGFEAAYVQWIINIPLFIAGVILLGGKFGLKTLAGSVF LPLVVFLTRDIQPATHHELLAAIFGGVGIGIGIGIVYLGKGSTGGTALAAQIIHKYSG LSLGKCLAIIDGMIVVTAMIVFNIEQGLYAMLGVYVSSKTIDVVQVGFNRSKMALIIT KQEQAVKEAVLQKIDRGVTKISAVGGYTDDDRPILMCVVGQTEFTKLKQIVKQIDESA FVIVADASEVLGEGFKRA*" /label="yvjA CDS" gene complement(3039925..3040809) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /label="yvjA gene" promotor_-35 complement(3039936..3039943) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" promotor_-10 complement(3040797..3040816) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3040818) /Source="Nicolas_upshifts" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" promotor_-35 complement(3040831..3040838) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" CDS join(complement(3041966..3042037), complement(3040936..3041964)) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /experiment="publication(s) with functional evidences, PMID:1408743, 9696765, 9882663" /ribosomal_slippage /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1408743, 9696765, 9882663; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 2" /protein_id="NP_391409.1" /db_xref="EnsemblGenomes-Gn:BSU35290" /db_xref="EnsemblGenomes-Tr:CAB15546" /db_xref="GOA:P28367" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004374" /db_xref="InterPro:IPR005139" /db_xref="InterPro:IPR020853" /db_xref="SubtiList:BG10742" /db_xref="UniProtKB/Swiss-Prot:P28367" /translation="MELSEIRAELENMASRLADFRGSLDLESKEARIAELDEQMADPE FWNDQQKAQTVINEANGLKDYVNSYKKLNESHEELQMTHDLLKEEPDTDLQLELEKEL KSLTKEFNEFELQLLLSEPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWGERRGF KVETLDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVS CEVMPEFNDEIDIDIRTEDIKVDTYRASGAGGQHVNTTDSAVRITHLPTNVVVTCQTE RSQIKNRERAMKMLKAKLYQRRIEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSMVK DHRTNTEMGNVQAVMDGDIDTFIDAYLRSKLS*" /label="prfB CDS" gene complement(3040936..3042037) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /label="prfB gene" downshifts complement(3040952) /Source="Nicolas_upshifts" /id="D1829" /incds=0 /nref=193 /ntot=257 /MaxReadThrough="2.78016" /MaxDrop="6.41678" /score="27.1588259" /energy="-9.8" /TU="NA" /idTUdmin="U2766" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(3042038..3042106) /Source="Nicolas_S_feature" /locus_tag="new_3628241_3628309_c" /HighExp="Etha, Sw, Cold, BC, G150, BI, dia15, Mt0, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1348" CDS complement(3042107..3044632) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="translocase binding subunit (ATPase)" /protein_id="NP_391410.1" /db_xref="EnsemblGenomes-Gn:BSU35300" /db_xref="EnsemblGenomes-Tr:CAB15547" /db_xref="GOA:P28366" /db_xref="InterPro:IPR000185" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR011115" /db_xref="InterPro:IPR011116" /db_xref="InterPro:IPR011130" /db_xref="InterPro:IPR014018" /db_xref="InterPro:IPR020937" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036266" /db_xref="InterPro:IPR036670" /db_xref="PDB:1M6N" /db_xref="PDB:1M74" /db_xref="PDB:1TF2" /db_xref="PDB:1TF5" /db_xref="PDB:2IBM" /db_xref="PDB:3DL8" /db_xref="PDB:3IQM" /db_xref="PDB:3IQY" /db_xref="PDB:3JV2" /db_xref="PDB:5EUL" /db_xref="SubtiList:BG10741" /db_xref="UniProtKB/Swiss-Prot:P28366" /translation="MLGILNKMFDPTKRTLNRYEKIANDIDAIRGDYENLSDDALKHK TIEFKERLEKGATTDDLLVEAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEMKT GEGKTLTSTLPVYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGLTVGLNLNSMS KDEKREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRPLHFAVIDEVDSILIDEAR TPLIISGQAAKSTKLYVQANAFVRTLKAEKDYTYDIKTKAVQLTEEGMTKAEKAFGID NLFDVKHVALNHHINQALKAHVAMQKDVDYVVEDGQVVIVDSFTGRLMKGRRYSEGLH QAIEAKEGLEIQNESMTLATITFQNYFRMYEKLAGMTGTAKTEEEEFRNIYNMQVVTI PTNRPVVRDDRPDLIYRTMEGKFKAVAEDVAQRYMTGQPVLVGTVAVETSELISKLLK NKGIPHQVLNAKNHEREAQIIEEAGQKGAVTIATNMAGRGTDIKLGEGVKELGGLAVV GTERHESRRIDNQLRGRSGRQGDPGITQFYLSMEDELMRRFGAERTMAMLDRFGMDDS TPIQSKMVSRAVESSQKRVEGNNFDSRKQLLQYDDVLRQQREVIYKQRFEVIDSENLR EIVENMIKSSLERAIAAYTPREELPEEWKLDGLVDLINTTYLDEGALEKSDIFGKEPD EMLELIMDRIITKYNEKEEQFGKEQMREFEKVIVLRAVDSKWMDHIDAMDQLRQGIHL RAYAQTNPLREYQMEGFAMFEHMIESIEDEVAKFVMKAEIENNLEREEVVQGQTTAHQ PQEGDDNKKAKKAPVRKVVDIGRNAPCHCGSGKKYKNCCGRTE*" /label="secA CDS" gene complement(3042107..3044632) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /label="secA gene" S_feature complement(3044633..3044713) /Source="Nicolas_S_feature" /locus_tag="new_3630836_3630916_c" /HighExp="Etha, M9-stat, T0.30H, B60, dia5, Cold, dia15, Lbexp, Salt, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1349" misc_feature complement(3044703..3044722) /Source="Nicolas_upshift_promotors" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3044713) /Source="Nicolas_upshifts" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3044800..3045369) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome-associated sigma 54 modulation protein;ribosome dimerisation factor" /protein_id="NP_391411.1" /db_xref="EnsemblGenomes-Gn:BSU35310" /db_xref="EnsemblGenomes-Tr:CAB15548" /db_xref="GOA:P28368" /db_xref="InterPro:IPR003489" /db_xref="InterPro:IPR032528" /db_xref="InterPro:IPR034694" /db_xref="InterPro:IPR036567" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10740" /db_xref="UniProtKB/Swiss-Prot:P28368" /translation="MNYNIRGENIEVTPALKDHVERKIGKLERYFDHSVDADVNVNLK FYNDKESKVEVTIPMTDLALRSEVHNEDMYNAIDLATNKLERQIRKHKTKVNRKFREQ GSPKYLLANGLGSDTDIAVQDDIEEEESLDIVRQKRFNLKPMDSEEAILQMNMLGHNF FVFTNAETNLTNVVYRRNDGKYGLIEPTE*" /label="hpf CDS" gene complement(3044800..3045369) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /label="hpf gene" downshifts complement(3044808) /Source="Nicolas_upshifts" /id="D1830" /incds=0 /nref=78 /ntot=209 /MaxReadThrough="8.66806" /MaxDrop="4.7023" /score="29.9030506" /energy="-12.2" /TU="U2768,U2769,U2770,U2773" /idTUdmin="U2773" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 3045336..3045342 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3045355..3045374 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3045362 /Source="Nicolas_upshifts" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3045396..3045414) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3045404) /Source="Nicolas_upshifts" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3045406..>3045507) /Source="Nicolas_S_feature" /locus_tag="new_3631609_3631729_c" /HighExp="C30, M0t90, S4, Lbstat, S5, M40t90, Glucon, Gly, C90, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigD, SigD" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1350" promotor_-35 complement(3045426..3045434) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 3045507..3045508 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_008" CDS complement(3045511..3045993) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:24706744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24706744; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for flagellar based motility" /protein_id="NP_391422.1" /db_xref="EnsemblGenomes-Gn:BSU35420" /db_xref="EnsemblGenomes-Tr:CAB15559" /db_xref="GOA:P39808" /db_xref="InterPro:IPR007809" /db_xref="InterPro:IPR036679" /db_xref="SubtiList:BG10400" /db_xref="UniProtKB/Swiss-Prot:P39808" /translation="MSAKAIIEQLKRLCVLHEHLLTLSEEKTEALKAGKTKELSNILT KEQKYIQAITQTEDDRIKTTSAFLGYSENNTISACIAKTSGSEKEELEQLYESLSQVL GRLKKVNEMNRQLTRDALQFISISYDMLVPKENNFNYSKSIKAELPKSSKMKLFDSKA *" /label="flgN CDS" gene complement(3045511..3045993) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /label="flgN gene" CDS complement(3046009..3046275) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma factor repressor of sigma(D)-dependent transcription" /protein_id="NP_391423.1" /db_xref="EnsemblGenomes-Gn:BSU35430" /db_xref="EnsemblGenomes-Tr:CAB15560" /db_xref="GOA:P39809" /db_xref="InterPro:IPR007412" /db_xref="InterPro:IPR031316" /db_xref="InterPro:IPR035890" /db_xref="SubtiList:BG10399" /db_xref="UniProtKB/Swiss-Prot:P39809" /translation="MKINQFGTQSVNPYQKNYDKQAVQKTVAQPQDKIEISSQAKEMQ HASDAVTGSRQEKIAQLKAQIENGSYKVDANHIAKNMINFYKKQ*" /label="flgM CDS" gene complement(3046009..3046275) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /label="flgM gene" S_feature complement(3046276..3046355) /Source="Nicolas_S_feature" /locus_tag="new_3640552_3640631_c" /HighExp="T0.30H, Cold, C90, T-5.40H, T-4.40H, GM 150, T-2.40H, GM 45, S2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1353" CDS complement(3046356..3046775) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696775; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of flagella formation" /protein_id="NP_391424.1" /db_xref="EnsemblGenomes-Gn:BSU35440" /db_xref="EnsemblGenomes-Tr:CAB15561" /db_xref="GOA:P39807" /db_xref="InterPro:IPR022258" /db_xref="SubtiList:BG10398" /db_xref="UniProtKB/Swiss-Prot:P39807" /translation="MGELANCPKCNALFLKTKLQTVCQACIKEEEKSFETVYKFLRKQ ENRQSTLSRITEETGVEEELILKFIRQKRIQITHLPNLAYPCERCGTSIREGKFCKAC QSDIKDQMDHLNHEDALKIEKENSKKDTYYAYNTKNS*" /label="yvyF CDS" gene complement(3046356..3046775) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /label="yvyF gene" promotor_-10 complement(3046814..3046832) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3046825) /Source="Nicolas_upshifts" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3046846..3046853) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3046849..3047571) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 28618091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the DNA transport apparatus" /protein_id="NP_391425.2" /db_xref="EnsemblGenomes-Gn:BSU35450" /db_xref="EnsemblGenomes-Tr:CAB15562" /db_xref="GOA:P39147" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005222" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10397" /db_xref="UniProtKB/Swiss-Prot:P39147" /translation="MSNEAGGGIHKLICLLCDSQFSQDVTWRALFLLKPDEKVCYSCR SKLKKITGHICPLCGRPQSVHAVCRDCEVWRTRIRDSLLLRQNRSVYTYNDMMKETLS RFKFRGDAEIINAFKSDFSSTFSKVYPDKHFVLVPIPLSKEREEERGFNQAHLLAECL DRPSHHPLIRLNNEKQSKKKKTERLLSECIFDTKNNSAEGMNIILIDDLYTTGATLHF AARCLLEKGKAASVSSFTLIRS*" /label="comFC CDS" gene complement(3046849..3047571) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /label="comFC gene" CDS complement(3047535..3047831) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 25423369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 25423369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of competence, pole located" /protein_id="NP_391426.1" /db_xref="EnsemblGenomes-Gn:BSU35460" /db_xref="EnsemblGenomes-Tr:CAB15563" /db_xref="GOA:P39146" /db_xref="InterPro:IPR019657" /db_xref="PDB:4WAI" /db_xref="SubtiList:BG10396" /db_xref="UniProtKB/Swiss-Prot:P39146" /translation="MLVNSKEIVMKELLDRYMDQLHMACTCQVCQNDVLALSLNKVSP SYVTDFKKIAYTKAELVDKQKNTAMLVILAESAAVVSESPSDLCQTKQEEAFIN*" /label="comFB CDS" gene complement(3047535..3047831) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /label="comFB gene" promotor_-10 complement(3047857..3047876) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3047870) /Source="Nicolas_upshifts" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3047887..3047894) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3047891..3049282) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045895, 11359569, 12123453, 16009133, 21397556, 28559293" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045895, 11359569, 12123453, 16009133, 21397556, 28559293; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase competence protein" /protein_id="NP_391427.1" /db_xref="EnsemblGenomes-Gn:BSU35470" /db_xref="EnsemblGenomes-Tr:CAB15564" /db_xref="GOA:P39145" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10395" /db_xref="UniProtKB/Swiss-Prot:P39145" /translation="MNVPVEKNSSFSKELQQTLRSRHLLRTELSFSDEMIEWHIKNGY ITAENSISINKRRYRCNRCGQTDQRYFSFYHSSGKNKLYCRSCVMMGRVSEEVPLYSW KEENESNWKSIKLTWDGKLSSGQQKAANVLIEAISKKEELLIWAVCGAGKTEMLFPGI ESALNQGLRVCIATPRTDVVLELAPRLKAAFQGADISALYGGSDDKGRLSPLMISTTH QLLRYKDAIDVMIIDEVDAFPYSADQTLQFAVQKARKKNSTLVYLSATPPKELKRKAL NGQLHSVRIPARHHRKPLPEPRFVWCGNWKKKLNRNKIPPAVKRWIEFHVKEGRPVFL FVPSVSILEKAAACFKGVHCRTASVHAEDKHRKEKVQQFRDGQLDLLITTTILERGVT VPKVQTGVLGAESSIFTESALVQIAGRTGRHKEYADGDVIYFHFGKTKSMLDARKHIK EMNELAAKVECTD*" /label="comFA CDS" gene complement(3047891..3049282) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /label="comFA gene" promotor_-10 complement(3049296..3049315) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3049311) /Source="Nicolas_upshifts" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3049329..3049336) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3049388..3050233) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /EC_number="2.7.2.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit A" /protein_id="NP_391428.1" /db_xref="EnsemblGenomes-Gn:BSU35480" /db_xref="EnsemblGenomes-Tr:CAB15565" /db_xref="GOA:P32436" /db_xref="InterPro:IPR003797" /db_xref="PDB:3FYS" /db_xref="SubtiList:BG10394" /db_xref="UniProtKB/Swiss-Prot:P32436" /translation="MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELD WKSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAA DSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFM VDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLD EDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGALGI CWCFK*" /label="fakBA CDS" gene complement(3049388..3050233) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /label="fakBA gene" downshifts complement(3049399) /Source="Nicolas_upshifts" /id="D1835" /incds=0 /nref=207 /ntot=249 /MaxReadThrough="2.43976" /MaxDrop="5.65998" /score="25.7738948" /energy="-9.9" /TU="NA" /idTUdmin="U2779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3049650..3049657 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3049671..3049690 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3049681..3051413 /Source="Nicolas_S_feature" /locus_tag="new_3643957_3645689" /HighExp="C30, S2, C90, Pyr, T0.30H, GM 150, G/S, T-4.40H, T-3.40H, T1.30H" /AntisenseName="degU" /AntisenseCor="1.0564647169900101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1354" upshifts 3049681 /Source="Nicolas_upshifts" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3050260..3050279) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3050279) /Source="Nicolas_upshifts" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3050294..3050297) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3050331..3051020) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_391429.1" /db_xref="EnsemblGenomes-Gn:BSU35490" /db_xref="EnsemblGenomes-Tr:CAB15566" /db_xref="GOA:P13800" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10393" /db_xref="UniProtKB/Swiss-Prot:P13800" /translation="MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARI VEHYHPDVVIMDINMPNVNGVEATKQLVELYPESKVIILSIHDDENYVTHALKTGARG YLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSAHPQHEVYPEIR RPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVV VAIKNGWVEMR*" /label="degU CDS" gene complement(3050331..3051020) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /label="degU gene" downshifts complement(3050345) /Source="Nicolas_upshifts" /id="D1836" /incds=0 /nref=178 /ntot=235 /MaxReadThrough="5.12878" /MaxDrop="6.38336" /score="20.9249268" /energy="-12.8" /TU="U2781" /idTUdmin="U2779" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature complement(3051021..3051102) /Source="Nicolas_S_feature" /locus_tag="new_3645297_3645378_c" /HighExp="M40t90, Lbtran, M0t90, LBGtran, G180, T3.0H, M40t45, C90, T3.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1355" CDS complement(3051103..3052260) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [DegU]" /protein_id="NP_391430.1" /db_xref="EnsemblGenomes-Gn:BSU35500" /db_xref="EnsemblGenomes-Tr:CAB15567" /db_xref="GOA:P13799" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008595" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR016381" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10392" /db_xref="UniProtKB/Swiss-Prot:P13799" /translation="MNKTKMDSKVLDSILMKMLKTVDGSKDEVFQIGEQSRQQYEQLV EELKQIKQQVYEVIELGDKLEVQTRHARNRLSEVSRNFHRFSEEEIRNAYEKAHKLQV ELTMIQQREKQLRERRDDLERRLLGLQEIIERSESLVSQITVVLNYLNQDLREVGLLL ADAQAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDRGAEDG FQEIKNLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLYTTEEYNGKVKIHFQ CIGETEDQRLAPQFEVALFRLAQEAVSNALKHSESEEITVKVEITKDFVILMIKDNGK GFDLKEAKEKKNKSFGLLGMKERVDLLEGTMTIDSKIGLGTFIMIKVPLSL*" /label="degS CDS" gene complement(3051103..3052260) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /label="degS gene" S_feature complement(3052261..3052388) /Source="Nicolas_S_feature" /locus_tag="new_3646537_3646664_c" /HighExp="T0.30H, Lbtran, M9-stat, T3.0H, T1.0H, HiOs, T1.30H, T2.30H, T3.30H, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1356" promotor_-35 3052308..3052311 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3052326..3052345 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3052337..3052423 /Source="Nicolas_S_feature" /locus_tag="new_3646613_3646699" /HighExp="UNK1, Cold, C30, Lbexp, MG 15, G135, G180, G150, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1357" upshifts 3052337 /Source="Nicolas_upshifts" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3052382..3052401) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3052388) /Source="Nicolas_upshifts" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3052405..3052413 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3052412..3052419) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3052425 /Source="Nicolas_upshifts" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3052427..3052435 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3052477..3053130 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11116084, 15103642, 21239490, 22404850; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative translation regulator" /protein_id="NP_391431.1" /db_xref="EnsemblGenomes-Gn:BSU35510" /db_xref="EnsemblGenomes-Tr:CAB15568" /db_xref="InterPro:IPR001498" /db_xref="InterPro:IPR015269" /db_xref="InterPro:IPR015796" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020569" /db_xref="InterPro:IPR023582" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR036956" /db_xref="SubtiList:BG11052" /db_xref="UniProtKB/Swiss-Prot:P32437" /translation="MLHSYFTVKEAGEHEIVIEKSRFICHLSRVSTEQEAQEFIQKIK KQHWNATHNCSAYVIGENDHIQKANDDGEPSGTAGVPMLEVLKKRRLKDTCAVVTRYF GGIKLGAGGLIRAYGKSVSEGLNHIGVVERKLMRIMHTSADYTWLGKIENELRESQFL LKEIHYSENVEFETYVEEKETNAFSEWMTELTNGKSDIKEGELTYLEKAVNHIKETE* " /label="yvyE CDS" gene 3052477..3053130 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /label="yvyE gene" S_feature complement(3052833..3053425) /Source="Nicolas_S_feature" /locus_tag="new_3647109_3647701_c" /HighExp="Etha, M9-stat, Gly, C30, B60, Salt, T0.30H, Sw, LoTm, S8" /AntisenseName="yvyE" /AntisenseCor="-0.139956338862644" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1358" CDS 3053130..3054305 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19099556, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain" /protein_id="NP_391432.1" /db_xref="EnsemblGenomes-Gn:BSU35520" /db_xref="EnsemblGenomes-Tr:CAB15569" /db_xref="GOA:P96499" /db_xref="InterPro:IPR004474" /db_xref="PDB:3NXH" /db_xref="SubtiList:BG12449" /db_xref="UniProtKB/Swiss-Prot:P96499" /translation="MAERVRVRVRKKKKSKRRKILKRIMLLFALALLVVVGLGGYKLY KTINAADESYDALSRGNKSNLRNEVVDMKKKPFSILFMGIEDYATKGQKGRSDSLIVV TLDPKNKTMKMLSIPRDTRVQLAGDTTGSKTKINAAYSKGGKDETVETVENFLQIPID KYVTVDFDGFKDVINEVGGIDVDVPFDFDEKSDVDESKRIYFKKGEMHLNGEEALAYA RMRKQDKRGDFGRNDRQKQILNALIDRMSSASNIAKIDKIAEKASENVETNIRITEGL ALQQIYSGFTSKKIDTLSITGSDLYLGPNNTYYFEPDATNLEKVRKTLQEHLDYTPDT STGTSGTEDGTDSSSSSGSTGSTGTTTDGTTNGSSYSNDSSTSSNNSTTNSTTDSSY* " /label="tagV CDS" gene 3053130..3054305 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /label="tagV gene" promotor_-10 complement(3053421..3053439) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3053430) /Source="Nicolas_upshifts" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3053453..3053459) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3054277 /Source="Nicolas_upshifts" /id="D1837" /incds=0 /nref=199 /ntot=276 /MaxReadThrough="2.38202" /MaxDrop="7.1642" /score="16.6000843" /energy="-18.6" /TU="NA" /idTUdmin="U2782" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(3054378..3055454) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /EC_number="2.7.8.33" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl-1-P transferase" /protein_id="NP_391433.1" /db_xref="EnsemblGenomes-Gn:BSU35530" /db_xref="EnsemblGenomes-Tr:CAB15570" /db_xref="GOA:O34753" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG12684" /db_xref="UniProtKB/Swiss-Prot:O34753" /translation="MLDERMIRIVVAFIVSLLTVLIITPIVKRIAIKIGAVDQPSNRK VHDKIMPRMGGLAIFIGVVAGVLASGIYTETRMTAITVGAFIIIVLGILDDKYQLSAK VKFLIQLGVAIMIVSTGLKMDFFSVPFLTERFELGWMAYPLTVLWIVGITNAINLIDG LDGLAAGLSVIGLSTIAVMALSGGKVLILSLSLVVIASTLGFLFYNFHPAKIFMGDTG SLFLGYSISILSLLGLYKSVTLFSIVIPIIILGVPIFDTTFAIIRRILNKQPISAPDK SHIHHRLMAFGLSHRMSVLVIYLIGFIFSISAIVLKSATIWLSLFIIFILIIFMQIIA EVTGLVNEKFKPFTKFYKRLVKRN*" /label="tagO CDS" gene complement(3054378..3055454) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /label="tagO gene" downshifts complement(3054394) /Source="Nicolas_upshifts" /id="D1838" /incds=0 /nref=221 /ntot=280 /MaxReadThrough="1.7614" /MaxDrop="8.41647" /score="29.109706" /energy="-11.6" /TU="NA" /idTUdmin="U2785" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 3054440..3054449 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3054463..3054482 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3054471..3055704 /Source="Nicolas_S_feature" /locus_tag="new_3648747_3649980" /HighExp="S8, S6, S7, S5, BT, S4, B36, Pyr, S3, G/S" /AntisenseName="tagO" /AntisenseCor="-0.60515751332040901" /AntisenseRegPval="-27.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1359" upshifts 3054471 /Source="Nicolas_upshifts" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3055455..3055537) /Source="Nicolas_S_feature" /locus_tag="new_3649731_3649813_c" /HighExp="LPhT, Cold, LoTm, T0.30H, T3.0H, LBGstat, T1.30H, T1.0H, T2.30H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67123699999999997" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1360" promotor_-10 complement(3055525..3055544) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3055537) /Source="Nicolas_upshifts" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3055556..3055562) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3055599..3056792) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391434.1" /db_xref="EnsemblGenomes-Gn:BSU35540" /db_xref="EnsemblGenomes-Tr:CAB15571" /db_xref="GOA:O32267" /db_xref="SubtiList:BG12695" /db_xref="UniProtKB/Swiss-Prot:O32267" /translation="METKEAIIHVIVATAEWGKDQLRYRRHRLAEFLAAQEETKEVIW VCPAPRAQGKEFQEVHSGIRQFAVKDLLQKKMFRFGRYTDVFYRHKLSPLLDELTPAS ANGERCCLWYTFPGFPLLSSLYSWDQVIYDCSDLWAAPISGRSNLLSEFRRKVIKSAE LRIIQRADSITCSSDYLHKEVDKKLTAGREKVHTVENGVEYELFSANKQAPDRSILQG REGIVLGFIGGIKPKLDFKMIKEAALQKPDWTFLWVGPDATNGDVSFQELLRLPNVIW TGPADPKEVPHYMELIDIGIMPYKQSPYNQAVFPLKLFEFLAAGKPVVGTNLPSTSKM QKPYVYEYVEGDHPIDFIAACEKVLGQNGDETYKEMRRNIARTQDWNCLFRQIMKYTG IQKHA*" /label="tuaH CDS" gene complement(3055599..3056792) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /label="tuaH gene" downshifts complement(3055629) /Source="Nicolas_upshifts" /id="D1839" /incds=0 /nref=23 /ntot=141 /MaxReadThrough="7.20583" /MaxDrop="4.88676" /score="4.72365619" /energy="-10.8" /TU="U2786" /idTUdmin="U2785" /TUdmin="-1236" /isTUend="FALSE" /label="downshifts" CDS complement(3056821..3057579) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391435.1" /db_xref="EnsemblGenomes-Gn:BSU35550" /db_xref="EnsemblGenomes-Tr:CAB15572" /db_xref="GOA:O32268" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12694" /db_xref="UniProtKB/Swiss-Prot:O32268" /translation="MTNWKPLVSVITPSYNARDYIEDTVHSVLDQSHPHWEMIIVDDC STDGTRDILQQYEKIDERIHVVYLEENSGAAVARNKALERAQGRYVAFLDSDDKWKKD KLEKQLEFMMERSCAFSFTGYSLMAQDGTPLDKFIHAPESLTYDDALKNTIIGCLTVM IDREQTGQIQMPNIRTRQDLATWLSLLKKGFTAYGMNECLAEYRLVNNSISSNKWKAA KKTWFVYREIERLHFMKATWCFVQYAKNAVKKRL*" /label="tuaG CDS" gene complement(3056821..3057579) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /label="tuaG gene" CDS complement(3057603..3058283) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase involved in teichuronic acid synthesis" /protein_id="NP_391436.1" /db_xref="EnsemblGenomes-Gn:BSU35560" /db_xref="EnsemblGenomes-Tr:CAB15573" /db_xref="GOA:O32269" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG12693" /db_xref="UniProtKB/Swiss-Prot:O32269" /translation="MNDILIRIARRIKKNIIWIIAVPIILGAAGYILPSQIADQKSYT AEDTLAVGSYDHPVYNSTEEIPLLLKSDSFLKEALPDEKDEDVAEIKEKLTINTESKS LLTLSYSDEDKDRTESVLNAISSTFLKNDQKLYAEREAVIRSSIDALEGESVSEDSKV DKERFLYELKNTQLNLKAASVTDSETVSETAGGGMSPKKKAVLGVMIGLTIAFMFVVI PEFFRESF*" /label="tuaF CDS" gene complement(3057603..3058283) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /label="tuaF gene" CDS complement(3058312..3059778) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 15849754, 16850406, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative polymerase of teichuronic acid repeating units" /protein_id="NP_391437.1" /db_xref="EnsemblGenomes-Gn:BSU35570" /db_xref="EnsemblGenomes-Tr:CAB15574" /db_xref="GOA:O32270" /db_xref="InterPro:IPR007016" /db_xref="SubtiList:BG12692" /db_xref="UniProtKB/Swiss-Prot:O32270" /translation="MSIKRSAVHTLALLAAAIFGVVLLLGAIHKDIGFMQMAAVLAVL AIGLFLLTLATAFTTKERLFMAVIYILIACTFLNNAFFAIHLGFFSLFLYRLLLIAAG CLHIFGMVRNRTHIERWHGLQVKGILLFFAFWFIYGLVSLLWAKSVTVGLKYLALLAM GIFFIYLIVMYVQKMERLMIVYAIWLVMTVFLMIIGFYNHITHHHLASSTLYSGPEYK QHYPTSVFFNQNDFATFLSISFFFYITMMKNIKNGYIKAIGLVLSLCALYLIFATGSR ASLLGIFAGIAVYIFIVLPPVLKRMAIWLSAAGIALFAVLFASKIYSKFWELFLAPQT LHSFHDRLPSNVARANLLKNAWHFFLDSYGFGVGAGNVSYYLEHYAVYDTDNVAEVHN WLVEILANFGLFIMLGYLSVYAYLIWVLYKFYERKLENQSKLITEGLITAMVSFLVSS ISPSSVSNLFFHWVFMALVIAAVNVLRRSRQMPEPMYR*" /label="tuaE CDS" gene complement(3058312..3059778) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /label="tuaE gene" S_feature complement(3059779..3059862) /Source="Nicolas_S_feature" /locus_tag="new_3654055_3654138_c" /HighExp="LPhT, S3, B60, S7, S4, S6, LBGstat, BI, S8, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1361" CDS complement(3059863..3061248) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10376820, 10913081, 12970183, 16000785, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376820, 10913081, 12970183, 16000785, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 6-dehydrogenase (teichuronic acid)" /protein_id="NP_391438.1" /db_xref="EnsemblGenomes-Gn:BSU35580" /db_xref="EnsemblGenomes-Tr:CAB15575" /db_xref="GOA:O32271" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12691" /db_xref="UniProtKB/Swiss-Prot:O32271" /translation="MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGV IPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKA AAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAI HDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISF INDIANICERVGADVSKVADGVGLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSA GYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALD IIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKE MELVKVKTLLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLE ELAKDLGSVNL*" /label="tuaD CDS" gene complement(3059863..3061248) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /label="tuaD gene" CDS complement(3061310..3062479) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391439.1" /db_xref="EnsemblGenomes-Gn:BSU35590" /db_xref="EnsemblGenomes-Tr:CAB15576" /db_xref="GOA:O32272" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG12690" /db_xref="UniProtKB/Swiss-Prot:O32272" /translation="MKILWITSVYPSSMKPGEGVFHETQVQELQKLGLDITVICPRPF HSAPVRMLKKTYRKKDVRPEYEIRKGIPVYRPFYRAVPGQLKWAQPHRRIASAVLKTM KQRDLYPDLIHAHFAMPSGGAAAVVSESAQIPYVLTLHGSDVNVYPHYSKGAFKAFKR AVGSASVVLAVSHKLQEEAKKLSGFDSSVLPIGIQLSRFQGNEETKEEIRKRLGLPLD QRLAVYVGRLVREKGIFELSEAIESLQDSPKAVFVGDGPAKSTLTQKGHIVTGQVPNH QVRDYLLAADLFVLPSYSEGMPTVVIEALALRVPVICTDVGGVSSLFGKHQHLLIKPK SAQALAEAITRYEHEQIWKPEVADDLYETVQAQFDAGKNAKALHHQYQTVTKTSV*" /label="tuaC CDS" gene complement(3061310..3062479) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /label="tuaC gene" CDS complement(3062476..3063927) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10048024, 11994144, 15849754, 16850406, 22720735, 26284661; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative exporter involved in biosynthesis of teichuronic acid" /protein_id="NP_391440.1" /db_xref="EnsemblGenomes-Gn:BSU35600" /db_xref="EnsemblGenomes-Tr:CAB15577" /db_xref="GOA:O32273" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG12689" /db_xref="UniProtKB/Swiss-Prot:O32273" /translation="MPSITKQIMSGAKWTSISTMCITIIQIVQFALLGNMMTLTEFGL VGMITTVTVFAQIVLDMGFGAALIQRDDATERQLSTLYWLNIMTGVLLFVLLYVSSPV IAGFYQREELVFLVRILAIMFLIAPIGQQYQYMLQKQLHFNTLSKIEIFSNVLSFGYL AIAVFMMDAILAYVISQVLLQSSKGILYWAVYRKKWHPAFVFDLRGMKDFFSFGAFQL SSRLVNRLGANIDMILIGRFIGAEALGIYNLAYQIVTIPVLKINPIVTRVAFPIFAKN KYENSVIREGFLNMTKMLALVSFPLLIGLVSVSDAFITAVFGEKWLAAVPILNVLAIV GILRVLMNPNGSVLLAKGRADLAFYWDSGVLLLYGLSLFAAVQTGSLLTVAWVYAIIS VVNFLIGRWLLAYVIKLNLSAYFQSIMKPFLITAAMGIIAFGVSLSTEHFSMQAEMRL AISVAAGALCYLFLLVKAYPQTKSKLLRKGRLS*" /label="tuaB CDS" gene complement(3062476..3063927) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /label="tuaB gene" CDS complement(3063983..3064132) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; C-terminal part of TuaA" /db_xref="SubtiList:BG12688" /translation="WAQVNGGYDMTPKEKLIFDLYYIRNLTFTLELKIMLKTCKVVWT GDGAR*" /label="tuaAc CDS" gene complement(3063983..3064132) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /pseudo /label="tuaAc gene" CDS complement(3064077..3064616) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /EC_number="2.7.8.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 10048024, 11994144, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; N-terminal part of TuaA" /translation="MSAEKSMNVSREFSVQQIHSFTLSEKTARYLAIKRVMDIWFALI GLAIALPMIAVFSILICLETPGPAIYTQERVGKGGKPFKLYKLRSMKIDAEKSGAVWA QKQDPRVTRIGAFIRRTRIDELPQLFNVLKGDMSMIGPRPERPVFTEKFQNEIPGFTQ RLGSGERRLRYDAEGKADI*" /label="tuaAn CDS" gene complement(3064077..3064616) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /pseudo /label="tuaAn gene" misc_feature complement(3064672..3064689) /Source="Nicolas_upshift_promotors" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3064676) /Source="Nicolas_upshifts" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3064843..3066333) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /EC_number="3.5.1.28" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1357079, 9537764, 14594841, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9537764, 14594841, 17298895, 19542270, 22469514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (major autolysin)" /protein_id="NP_391442.1" /db_xref="EnsemblGenomes-Gn:BSU35620" /db_xref="EnsemblGenomes-Tr:CAB15579" /db_xref="GOA:Q02114" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007253" /db_xref="SubtiList:BG10407" /db_xref="UniProtKB/Swiss-Prot:Q02114" /translation="MRSYIKVLTMCFLGLILFVPTALADNSVKRVGGSNRYGTAVQIS KQMYSTASTAVIVGGSSYADAISAAPLAYQKNAPLLYTNSDKLSYETKTRLKEMQTKN VIIVGGTPAVSSNTANQIKSLGISIKRIAGSNRYDTAARVAKAMGATSKAVILNGFLY ADAPAVIPYAAKNGYPILFTNKTSINSATTSVIKDKGISSTVVVGGTGSISNTVYNKL PSPTRISGSNRYELAANIVQKLNLSTSTVYVSNGFSYPDSIAGATLAAKKKQSLILTN GENLSTGARKIIGSKNMSNFMIIGNTPAVSTKVANQLKNPVVGETIFIDPGHGDQDSG AIGNGLLEKEVNLDIAKRVNTKLNASGALPVLSRSNDTFYSLQERVNKAASAQADLFL SIHANANDSSSPNGSETYYDTTYQAANSKRLAEQIQPKLAANLGTRDRGVKTAAFYVI KYSKMPSVLVETAFITNASDASKLKQAVYKDKAAQAIHDGTVSYYR*" /label="lytC CDS" gene complement(3064843..3066333) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /label="lytC gene" downshifts complement(3064865) /Source="Nicolas_upshifts" /id="D1840" /incds=0 /nref=145 /ntot=213 /MaxReadThrough="3.26689" /MaxDrop="6.50948" /score="13.9455176" /energy="-13.3" /TU="NA" /idTUdmin="U2788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3066372..3068489) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 16306698, 17269748" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 16306698, 17269748; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modifier of major autolysin amidase LytC" /protein_id="NP_391443.1" /db_xref="EnsemblGenomes-Gn:BSU35630" /db_xref="EnsemblGenomes-Tr:CAB15580" /db_xref="GOA:Q02113" /db_xref="InterPro:IPR007253" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="SubtiList:BG10406" /db_xref="UniProtKB/Swiss-Prot:Q02113" /translation="MKSCKQLIVCSLAAILLLIPSVSFAADSNISVKLLNYIGNKSSI SLSPTGFYKVTGDNVAVTDRFAGASRYETATLASNSQWKNPNTVILVNRDIFIDALPV IPLAKKLNAPVLFTQPDTLTKTTERQIAKFNPDNILIIGGARSISKDVENKLKSYGAV KRISGKNRYVLSENIAKQMGSYDKAIVVTGRVFQDALAIAPYAAAHGYPILLTEKDKL PDYDLPKQVIIIGSSFSVSDSVENQIKKTSTVQRIPGSTRYELTANIIKQLKLKADKV VMTNGTKYADVLIGASLASKKNSQILFVKQDSVPAAAKSITKDKATYAYDFIGSTSSI SAEVENSLADEFYLADGGTYNLKINSGKLNLENIKTYGNSLRIKPENYSTSNRISLDG KQYLGTVNFSIESTKYIRPVNENIPFEDYLKGVIPNEMPASWSLEALKAQTVAARTYS ITKTGTTVPDTTAFQVYGGYSWNSNTNKAVEQTKGKVLKYNGSLITAAYSSSNGGYTE ASNEVWSSSVPYLIAKKDTKDPQIGWTLTLSKQQLDTKSLDLTKPSSWWSSATETDSA RLSGVKNWILKNKETSADSVKIASIDDLSFSGTTQGQRAKTASMKVKYFVKSSTGSYN LSKITTISVPTSELRTMIGATVFKSTYVTVKKDTSKYTISGKGYGHGIGMSQYGAKAR AEAGDSYSSILKFYYPGTTLTSY*" /label="lytB CDS" gene complement(3066372..3068489) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /label="lytB gene" CDS complement(3068513..3068821) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1357079, 10974124, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 10974124, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="membrane bound lipoprotein" /protein_id="NP_391444.1" /db_xref="EnsemblGenomes-Gn:BSU35640" /db_xref="EnsemblGenomes-Tr:CAB15581" /db_xref="GOA:Q02112" /db_xref="SubtiList:BG10405" /db_xref="UniProtKB/Swiss-Prot:Q02112" /translation="MKKFIALLFFILLLSGCGVNSQKSQGEDVSPDSNIETKEGTYVG LADTHTIEVTVDNEPVSLDITEESTSDLDKFNSGDKVTITYEKNDEGQLLLKDIERAN *" /label="lytA CDS" gene complement(3068513..3068821) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /label="lytA gene" downshifts 3068727 /Source="Nicolas_upshifts" /id="D1841" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.03108" /MaxDrop="2.46089" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2787" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 3068817..3068821 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3068830..3068844 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3068831..3068849) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3068837 /Source="Nicolas_upshifts" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3068863..3068870) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3068866) /Source="Nicolas_upshifts" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3068887..3068895 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3068909..3068922 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3068927 /Source="Nicolas_upshifts" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="upshifts" CDS 3069005..3069925 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 9636707, 12034833, 19099556, 28197687, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9636707, 12034833, 19099556, 28197687, 29107701; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of major autolysin expression" /protein_id="NP_391445.1" /db_xref="EnsemblGenomes-Gn:BSU35650" /db_xref="EnsemblGenomes-Tr:CAB15582" /db_xref="GOA:Q02115" /db_xref="InterPro:IPR004474" /db_xref="InterPro:IPR023734" /db_xref="SubtiList:BG10404" /db_xref="UniProtKB/Swiss-Prot:Q02115" /translation="MRNERRKKKKTLLLTILTIIGLLVLGTGGYAYYLWHKAASTVAS IHESIDKSKKRDKEVSINKKDPFSVLIMGVDERDGDKGRADTLIYMTVNPKTNTTDMV SIPRDTYTKIIGKGTMDKINHSYAFGGTQMTVDTVENFLDVPVDYFVKVNMESFRDVV DTLGGITVNSTFAFSYDGYSFGKGEITLNGKEALAYTRMRKEDPRGDFGRQDRQRQVI QGIINKGANISSITKFGDMFKVVENNVKTNLTFDNMWDIQSDYKGARKHIKQHELKGT GTKINGIYYYQADESALSDITKELKESLEK*" /label="tagU CDS" gene 3069005..3069925 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /label="tagU gene" downshifts 3069915 /Source="Nicolas_upshifts" /id="D1842" /incds=0 /nref=224 /ntot=261 /MaxReadThrough="0.434639999999999" /MaxDrop="6.11301" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2789" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3069965..3071107) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /EC_number="5.1.3.14" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12107153, 16952950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12107153, 16952950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmannosamine 2-epimerase" /protein_id="NP_391446.1" /db_xref="EnsemblGenomes-Gn:BSU35660" /db_xref="EnsemblGenomes-Tr:CAB15583" /db_xref="GOA:P39131" /db_xref="InterPro:IPR003331" /db_xref="InterPro:IPR029767" /db_xref="PDB:1O6C" /db_xref="PDB:4FKZ" /db_xref="SubtiList:BG10403" /db_xref="UniProtKB/Swiss-Prot:P39131" /translation="MKKLKVMTVFGTRPEAIKMAPLVLELKKYPEIDSYVTVTAQHRQ MLDQVLDAFHIKPDFDLNIMKERQTLAEITSNALVRLDELFKDIKPDIVLVHGDTTTT FAGSLAAFYHQIAVGHVEAGLRTGNKYSPFPEELNRQMTGAIADLHFAPTGQAKDNLL KENKKADSIFVTGNTAIDALNTTVRDGYSHPVLDQVGEDKMILLTAHRRENLGEPMEN MFKAIRRIVGEFEDVQVVYPVHLNPVVREAAHKHFGDSDRVHLIEPLEVIDFHNFAAK SHFILTDSGGVQEEAPSLGKPVLVLRDTTERPEGVEAGTLKLAGTDEENIYQLAKQLL TDPDEYKKMSQASNPYGDGEASRRIVEELLFHYGYRKEQPDSFTGK*" /label="mnaA CDS" gene complement(3069965..3071107) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /label="mnaA gene" downshifts complement(3069989) /Source="Nicolas_upshifts" /id="D1843" /incds=0 /nref=126 /ntot=236 /MaxReadThrough="0.41249" /MaxDrop="5.56107" /score="7.64930656" /energy="-11" /TU="NA" /idTUdmin="U2790" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3071146..3071165) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3071160) /Source="Nicolas_upshifts" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3071180..3071183) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3071236..3071240 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3071256..3071275 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3071257..3071352 /Source="Nicolas_S_feature" /locus_tag="new_3665533_3665628" /HighExp="C90, dia5, Salt, Lbexp, T1.0H, MG 5, GM 90, MG 45, LoTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1362" upshifts 3071258 /Source="Nicolas_upshifts" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="upshifts" CDS 3071353..3072231 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2846750, 8126437, 8320212, 9658024, 17662947, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846750, 8126437, 8320212, 9658024, 17662947, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_391447.1" /db_xref="EnsemblGenomes-Gn:BSU35670" /db_xref="EnsemblGenomes-Tr:CAB15584" /db_xref="GOA:Q05852" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10402" /db_xref="UniProtKB/Swiss-Prot:Q05852" /translation="MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIIEE AVEAGIEDIIIVTGKSKRAIEDHFDYSPELERNLEEKGKTELLEKVKKASNLADIHYI RQKEPKGLGHAVWCARNFIGDEPFAVLLGDDIVQAETPGLRQLMDEYEKTLSSIIGVQ QVPEEETHRYGIIDPLTSEGRRYQVKNFVEKPPKGTAPSNLAILGRYVFTPEIFMYLE EQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYDVGEKLGFITTTLEFAMQDKELR DQLVPFMEGLLNKEEI*" /label="gtaB CDS" gene 3071353..3072231 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /label="gtaB gene" S_feature 3072232..3073323 /Source="Nicolas_S_feature" /locus_tag="new_3666508_3667599" /HighExp="Etha, Gly, C30, M9-stat, B60, T1.30H, B36, T1.0H, M40t90, T0.30H" /AntisenseName="yvzH" /AntisenseCor="-0.24043295548020899" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1363" S_feature complement(3072301..3072656) /Source="Nicolas_S_feature" /locus_tag="new_3666577_3666932_c" /HighExp="C30, LPh, HPh, Gly, G135, HiOs, aero, GM 25, MG 25, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.74940200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig="0.996" /label="S1364" CDS 3072565..3072783 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514004.1" /translation="MATILIPLTTLLDLSRIVGLIENHGIKPASIQTIKGTSPIPVMT SLLLRIPNTNQYAIIRIRGFKTCHNTPK*" /label="hypothetical protein CDS" gene 3072565..3072783 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /label="gene" CDS complement(3072657..3072740) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative teichoic acid translocation permease protein tagG (fragment)" /db_xref="PSEUDO:CAX52700.1" /translation="MMAYWFVFGMRNSKLVITGIGEVPFIV*" /label="yvzH CDS" gene complement(3072657..3072740) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /pseudo /label="yvzH gene" S_feature complement(3072741..3072932) /Source="Nicolas_S_feature" /locus_tag="new_3667017_3667208_c" /HighExp="HPh, LPh, C30, Gly, S0, HiOs, aero, G135, Mal, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1365" CDS complement(3072933..3075635) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16735734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16735734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase" /protein_id="NP_391448.1" /db_xref="EnsemblGenomes-Gn:BSU35680" /db_xref="EnsemblGenomes-Tr:CAB15585" /db_xref="GOA:P46918" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR007554" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11192" /db_xref="UniProtKB/Swiss-Prot:P46918" /translation="MNEKSFNYDFSVIMPIYNVELYLTEAIESIINQTIGFENIQLIL VNDDSPDKSEIICKEYAQKYPNNIVYAKKQNGGVSSARNYGLKYAEGRYIQFLDPDDL VSEGTFENVLNFFDEHKNEIDIVAIPIFFAEGRTGEHNLNNKFSSTRILDVEKEPHHI LTHCCSTFIKKDALKNIRFDENCKIGEDAKLVNLIISQKKKYGLVKEAKYHYRVREDG SSAMQTAKANKNWFNHSLITFSKNLIDIIKNHEQKIPLFLQYMVMHDLKWKLLIKDIS ETPLDENEYSEFLTLIREVLSYIDDDVIIETKSVSHFYLYHALKIKHGENYSRYVYER ETEQDYYLYREGKIVSKLSDQTLTIEILEENEDSIHIEGFWSSLFNSKGFKFYAKIGE TKIKAKNIKRQHNDYISLGEVIKKYPGFSIDIPKGHLADNHHIEFFITKGKKRKLTKL RFFKYSGLSNDLYNTYVAKKDYIFYYNYKKLMFKKNNFKNRFIKEFRFLKSLHKSGEK SKKRKSAIKKALMARMVHHVFTIFNRKPVWLFIDRQDKADDNAEHLFKYAINKNDGVK KYFIIKKDSKDYDRIKKYGKVIPYRSFRHKILTLSSSKVISTHADIWVVNPFFNMEIY FRDLFNFEFIFLQHGITMADHSEWLNKYNKNIKLLVTSAKPEYRSIVKGNYNYKKENI LLGGFPRYDNLKKSEGEKQLLIMPTWRKDIVLPKDQAKGVRPYNPKFKDSEYFSRYNA LINDERLIEFAKKNNYKITFFPHPDIQQQIVDFEKHDYVEFADYNSSYQMLFNSSNIM ITDFSSVAFDFAYEKKPVIYYQYEKSYHFKLDYYDYKKMGFGDVLENHNSLVDKVIYY MKNNSRMEDKYRKRVDNFFAYTDKNNRNRIYNAILELDNNKVAK*" /label="ggaB CDS" gene complement(3072933..3075635) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /label="ggaB gene" S_feature complement(3075636..3075758) /Source="Nicolas_S_feature" /locus_tag="new_3669912_3670034_c" /HighExp="BMM, HiOs, MG 15, C30, SMM, GM 90, HPh, MG 150, MG 25, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1366" promotor_-35 3075657..3075663 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3075678..3075696 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3075683..3078515 /Source="Nicolas_S_feature" /locus_tag="new_3669959_3672791" /HighExp="Sw, LoTm, M9-stat, Salt, B60, T0.30H, Gly, T1.0H, B36, BI" /AntisenseName="ggaA" /AntisenseCor="-0.503651102561819" /AntisenseRegPval="-18" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1367" upshifts 3075683 /Source="Nicolas_upshifts" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3075759..3077099) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16735734, 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase (missing signal peptide)" /db_xref="EnsemblGenomes-Gn:BSU35690" /db_xref="EnsemblGenomes-Tr:CAB15586" /db_xref="GOA:P46917" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PSEUDO:CAB15586.1" /db_xref="SubtiList:BG11367" /db_xref="UniProtKB/Swiss-Prot:P46917" /translation="MFSIIIPIYNSENYLRYSIESVLNQSIGFKENIELILIDDGSVD SSPQICESFKNLYPNNIKIMKIENSGPSAARNCGLSNVSERSKFIGFLDSDDAFSQNA LQSVYDFFCDSEHVNIAVLPVYYTGEKEGGHKLNNRFEKGTRVINILNDYKAIHFYIG GTFYRRHTLTSTVLFDESIKFWEDAIFFNQLLLKEKRYGAVAEGKYFYRKRKEQDSLV DRSWFNKKRYTYLLNECYMTLLMDSFNKYDIVLPYLQFLIVYHIKLFLYPNYRDVYKS VLDQQEQRVFVDDFIKVLKFIDPQFIKEQDMPMYYKEFMFHLLKENTEALENIKKERV LHSSCTVTSAKIKGLRLELTGHFINQYYEMKENDRIYIKYFKRLKKCKRKELKKTIEV WGYKLRDFRYAGFVVEIPIWAFAFDFVLKTPNDSLELNHVNIFKSLLTRVFKKR*" /label="ggaA CDS" gene complement(3075759..3077099) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /pseudo /label="ggaA gene" CDS complement(3077140..3077346) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /EC_number="2.7.8.12" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (fragment)" /db_xref="PSEUDO:CAX52701.1" /translation="MYDLPAYRDCIRGFYFNFQQKTPGNLLQTSEELIDTVKELLHNP YIDHNYEDFYNKFCNLEEARLLKE*" /label="yvzI CDS" gene complement(3077140..3077346) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /pseudo /label="yvzI gene" S_feature complement(3077347..3078220) /Source="Nicolas_S_feature" /locus_tag="new_3671623_3672496_c" /HighExp="HiOs, Heat, BMM, MG 15, GM 90, MG 25, MG 150, C30, GM 25, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99943499999999996" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1368" promotor_-10 complement(3078214..3078233) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3078220) /Source="Nicolas_upshifts" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3078222..3078461) /Source="Nicolas_S_feature" /locus_tag="new_3672498_3672737_c" /HighExp="Cold, LBGstat, C30, GM 25, GM 15, GM 45, GM 60, GM 10, GM-0.2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1369" promotor_-35 complement(3078246..3078252) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3078443..3078461) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-10" upshifts complement(3078461) /Source="Nicolas_upshifts" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="upshifts" promotor_-35 complement(3078475..3078482) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-35" promotor_-35 3078484..3078491 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3078503..3078522 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3078517..3078647 /Source="Nicolas_S_feature" /locus_tag="new_3672793_3672923" /HighExp="Sw, T0.30H, LoTm, B60, T1.0H, Lbtran, C30, LBGtran, dia5, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1370" upshifts 3078517 /Source="Nicolas_upshifts" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3078589..3078689 /Source="Nicolas_upshift_promotors" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3078649 /Source="Nicolas_upshifts" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS 3078653..3079249 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /EC_number="2.7.7.9" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase) (UDPGP) (fragment)" /db_xref="PSEUDO:CAX52702.1" /translation="MISFFHYILQKEPKGLGHAVWFAPNFIGDEPFAFLLGDDIVQAD TPGLRQLTDEYERTLSSIIGVQQVPEDETHCYGIIAPLTSEGRRYQVKNFIEKPPKDT APSNLAILGRYVFTPEIFMYLEEQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYD VGEKLGFITTTLEFAMQDKELRDQLVPFMEGLLNKEEI*" /label="yvzE CDS" gene 3078653..3079249 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /pseudo /label="yvzE gene" downshifts 3078847 /Source="Nicolas_upshifts" /id="D1844" /incds=1 /nref=94 /ntot=183 /MaxReadThrough="4.62614" /MaxDrop="5.15039" /score="34.2325445" /energy="-14.3" /TU="U2792,U2795" /idTUdmin="U2796" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3079288..3080871) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /EC_number="3.6.3.40" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 17012386, 18156271; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding teichoic acid precursor transporter component" /protein_id="NP_391451.1" /db_xref="EnsemblGenomes-Gn:BSU35700" /db_xref="EnsemblGenomes-Tr:CAB15587" /db_xref="GOA:P42954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015860" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030284" /db_xref="SubtiList:BG11191" /db_xref="UniProtKB/Swiss-Prot:P42954" /translation="MKLKVSFRNVSKQYHLYKKQSDKIKGLFFPAKDNGFFAVRNVSF DVYEGETIGFVGINGSGKSTMSNLLAKIIPPTSGEIEMNGQPSLIAIAAGLNNQLTGR DNVRLKCLMMGLTNKEIDDMYDSIVEFAEIGDFINQPVKNYSSGMKSRLGFAISVHID PDILIIDEALSVGDQTFYQKCVDRINEFKKQGKTIFFVSHSIGQIEKMCDRVAWMHYG ELRMFDETKTVVKEYKAFIDWFNKLSKKEKETYKKEQTEERKKEDPEAFARFRKKKKK PKSLANAIQIAILSILTVFMAGTMFFNAPLRTIASFGAIPQNEVKNHHGDAKGKSEER LTAINKQGFIANEKAAAYKDQGLKQKADVTLPFGTKVTVAAKGKQAAKIKFDGHSYYV KQSAVATNMKHAELHATAFTSYVSQNAASSYEYFLKFLGDSSTSIQSKLNGYTEGNKA DGRKTLNFDYEKISYVLENDKATELIFHNISPINPASLSLSDSDVLYDSSKKRFLVNT DDQVFAVDNEEHTLTLMLK*" /label="tagH CDS" gene complement(3079288..3080871) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /label="tagH gene" downshifts 3079331 /Source="Nicolas_upshifts" /id="D1845" /incds=0 /nref=2 /ntot=19 /MaxReadThrough="1.20059" /MaxDrop="5.25978" /score="34.2325445" /energy="-14.3" /TU="NA" /idTUdmin="U2792" /TUdmin=440 /isTUend="FALSE" /label="downshifts" CDS complement(3080891..3081718) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 15849754, 16850406, 17012386, 18156271, 27213893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="teichoic acid precursors permease" /protein_id="NP_391452.1" /db_xref="EnsemblGenomes-Gn:BSU35710" /db_xref="EnsemblGenomes-Tr:CAB15588" /db_xref="GOA:P42953" /db_xref="InterPro:IPR000412" /db_xref="InterPro:IPR013525" /db_xref="SubtiList:BG11205" /db_xref="UniProtKB/Swiss-Prot:P42953" /translation="MNDLLRILREQITSFPLILRLAAYETKSKYQMNYLGVLWQFLNP LIQMLAYWFVFGMGIRKGGPVTTGAGEVPFIIWMLAGLIPWFFISPTILDGSNSVFKR INMVAKMNFPISSLPSVAIASNLFSYMIMMVIYIIVLLVNGVFPSVHWLQYIYYFICM IAFMFSFSLFNSTISVLIRDYQFLLQAVTRLLFFLLPIFWDVNAKLGQSHPELVPVLK LNPLFYIIEGFRNSFLDGAWFFHDMKYTLYFWLFTFLLLLVGSILHMKFRDKFVDFL* " /label="tagG CDS" gene complement(3080891..3081718) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /label="tagG gene" S_feature complement(3081719..3081783) /Source="Nicolas_S_feature" /locus_tag="new_3675995_3676059_c" /HighExp="H2O2, LBGstat, dia15, Oxctl, LBGexp, G150, Paraq, G180, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1371" promotor_-10 complement(3081779..3081798) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3081783) /Source="Nicolas_upshifts" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3081785..3081882) /Source="Nicolas_S_feature" /locus_tag="new_3676061_3676158_c" /HighExp="G180, G135, Cold, G150, LPh, S0, Oxctl, Paraq, HPh, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1372" promotor_-35 complement(3081814..3081817) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3081883..3084123) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /EC_number="2.7.8.12" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase)" /protein_id="NP_391453.1" /db_xref="EnsemblGenomes-Gn:BSU35720" /db_xref="EnsemblGenomes-Tr:CAB15589" /db_xref="GOA:P13485" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10725" /db_xref="UniProtKB/Swiss-Prot:P13485" /translation="MSLVVDTNKRKQKGKSFYTEEQKKVMIENTVIKCILKSLKNNLG SLELLISIDSEHQFLEDYQLFLKLKERRSGTESEFPLQNTGSLEYKTEINAHVLPMPV EMGQTYDFYVEFRKKYEDAEQEPLLKRLSAEVNSIERAFHVDQTTELLILPYTTDKGN FSIKVKREAKIIRFDQIEISSEEISITGYAGYLSSENQYRIKNLNLILKKGGETPIEE KFPIKLERKTHGLENMRADGFVPELYDFEVKVPLKEIPFSNEKRYVYRLFMEYICNDD EGTDIQFNSTALVLGDRKNKLKGLVSIIKTNNAPVRYEVFKKKKKQTLGIRVNDYSLK TRMKYFIKGKKKRLVSKIKKITKMRNKLITKTYKSLFMMASRMPVKRKTVIFESFNGK QYSCNPRAIYEYMRENHPEYKMYWSVNKQYSAPFDEKGIPYINRLSLKWLFAMARAEY WVVNSRLPLWIPKPSHTTYLQTWHGTPLKRLAMDMEEVHMPGTNTKKYKRNFIKEASN WDYLISPNGYSTEIFTRAFQFNKTMIESGYPRNDFLHNDNNEETISLIKSRLNIPRDK KVILYAPTWRDDQFYAKGRYKFDLDLDLHQLRQELGNEYIVILRMHYLVAENFDLGPF EGFAYDFSAYEDIRELYMVSDLLITDYSSVFFDFANLKRPMLFFVPDIETYRDKLRGF YFDFEKEAPGPLVKTTEETIEAIKQISSPDYKLPVSFGPFYDKFCYLESGRSSEKVVN TVFKAE*" /label="tagF CDS" gene complement(3081883..3084123) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /label="tagF gene" CDS complement(3084123..3086144) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /EC_number="2.4.1.52" /function="16.8: Protect" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose:polyglycerol phosphate alpha-glucosyltransferase" /protein_id="NP_391454.1" /db_xref="EnsemblGenomes-Gn:BSU35730" /db_xref="EnsemblGenomes-Tr:CAB15590" /db_xref="GOA:P13484" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR015397" /db_xref="SubtiList:BG10724" /db_xref="UniProtKB/Swiss-Prot:P13484" /translation="MSLHAVSESNIKQIPDMDYYFISGGLPSNYGGLTKSLLLRSKLF GEECNQNTFFLTFRFDLELSSKIDELYSNGKIDKKFTSVINLFDDFLSVRTNGKRSYE ERIGLDQIKKQVGMGKFAKTLLRLFGKKNNEMSVVYYGDGETIRYVDYWNDKNQLIKR EEYTKNGNLVLVTHYDVQLNKMYLQEYINDQNQVYLDKLYVWNNEEKDVQLSHIIWYS LEGEIKVKDESELRQYWIEYLQKQNDKPKLFLVDSRPQDKHVFKVKKSPSSYYGAIIH NKHYGSNKYQIKGRYKEVFSQMYNLDAVFFITEEQLEDFKLISGEQETFFFTPHTIDK PLDPAVLNVPSEKYKAVIISRLASMKNLIHAVKAFSLVVKEIPEAKLDIFGSGEDFEK IKKEIEDTKLQNNVFLKGYTDNPDSEFQKAWLTISTSHFEGFGLSNMEALSNGCPVVT YDYDYGARSLVTDGANGYVIEQYNIEKLGQAIISLMKDESTHQKFSEQAFKMAEKYSR PNYIENWAFALNQMIEVRIEREKFSKKVGKKDPSISSYTEDFDKTKIEIDIENFDHND IKKIRLVGLDRKNKAEIISTNLQNDQLFVIDLEKDVNIEKIAANKTQVIDFYIVFNAN GHIKTMRRLSSEETKLSGNSIDTNNGYRVEPYTTVKGNFSWRVTEIKES*" /label="tagE CDS" gene complement(3084123..3086144) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /label="tagE gene" promotor_-35 3084886..3084895 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3084908..3084923 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3084919 /Source="Nicolas_upshifts" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3086145..3086304) /Source="Nicolas_S_feature" /locus_tag="new_3680421_3680580_c" /HighExp="G180, G135, Cold, G150, Oxctl, LBGexp, Paraq, Lbexp, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1373" CDS complement(3086305..3086694) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /EC_number="2.7.7.39" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol-3-phosphate cytidylyltransferase" /protein_id="NP_391455.1" /db_xref="EnsemblGenomes-Gn:BSU35740" /db_xref="EnsemblGenomes-Tr:CAB15591" /db_xref="GOA:P27623" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR006409" /db_xref="InterPro:IPR014729" /db_xref="PDB:1COZ" /db_xref="PDB:1N1D" /db_xref="SubtiList:BG10449" /db_xref="UniProtKB/Swiss-Prot:P27623" /translation="MKKVITYGTFDLLHWGHIKLLERAKQLGDYLVVAISTDEFNLQK QKKAYHSYEHRKLILETIRYVDEVIPEKNWEQKKQDIIDHNIDVFVMGDDWEGKFDFL KDQCEVVYLPRTEGISTTKIKEEIAGL*" /label="tagD CDS" gene complement(3086305..3086694) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /label="tagD gene" S_feature complement(3086695..3086829) /Source="Nicolas_S_feature" /locus_tag="new_3680971_3681105_c" /HighExp="BC, Cold, T3.0H, HiOs, MG-0.2, T1.30H, T3.30H, LPhT, MG 15, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1374" promotor_-10 complement(3086813..3086832) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3086829) /Source="Nicolas_upshifts" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3086843..3086850) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3086984..3086990 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3087001..3087093 /Source="Nicolas_S_feature" /locus_tag="new_3681277_3681369" /HighExp="B60, LoTm, Cold, T3.30H, T3.0H, Salt, T5.0H, T4.0H, Lbexp, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1375" upshifts 3087001 /Source="Nicolas_upshifts" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3087002..3087021 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3087094..3087864 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /EC_number="2.4.1.187" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase" /protein_id="NP_391456.1" /db_xref="EnsemblGenomes-Gn:BSU35750" /db_xref="EnsemblGenomes-Tr:CAB15592" /db_xref="GOA:P27620" /db_xref="InterPro:IPR004629" /db_xref="InterPro:IPR034714" /db_xref="SubtiList:BG10450" /db_xref="UniProtKB/Swiss-Prot:P27620" /translation="MQTETIHNIPYVNSNLTSFIDYLEKHYIDQKIGAVISTVNPEIA FAAIKDRDYFDVLSSSNFILPDGIGVVMMSRLTNNRLQSRIAGYDVFKELLGVANKKK KRIFLYGAKKDVIKGVVSKISSEYPNIKIAGYSDGYVQDRTLVAKQIARANPDMVFVA LGYPHQEKFIHNYRHLFPKAVSIGLGGSFDVFSGNVKRAPSWMIRLNLEWFYRLILNP WRWKRMLSIPKYALTVLKEEKNKKTFYPKPEKDHTKQI*" /label="tagA CDS" gene 3087094..3087864 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /label="tagA gene" S_feature complement(3087221..3087569) /Source="Nicolas_S_feature" /locus_tag="new_3681497_3681845_c" /HighExp="S8, S6, S7, S5, S4, G135, S3, C30, G180, ferm" /AntisenseName="tagA" /AntisenseCor="-0.35014495927301897" /AntisenseRegPval="-8.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1376" promotor_-10 complement(3087573..3087584) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3087577) /Source="Nicolas_upshifts" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3087599..3087605) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3087889 /Source="Nicolas_upshifts" /id="D1846" /incds=0 /nref=2 /ntot=103 /MaxReadThrough="6.64821" /MaxDrop="3.225" /score="-6.01444425" /energy="-10.9" /TU="U2800" /idTUdmin="U2800" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" CDS 3087897..3089042 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /EC_number="2.7.8.44" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid primase, CDP-glycerol:N-acetyl-beta-d-mannosaminyl-1, 4-N-acetyl-d-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase" /protein_id="NP_391457.1" /db_xref="EnsemblGenomes-Gn:BSU35760" /db_xref="EnsemblGenomes-Tr:CAB15593" /db_xref="GOA:P27621" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10451" /db_xref="UniProtKB/Swiss-Prot:P27621" /translation="MKIRSLLANCYLYFLSAIAFFLQWVKPESKVTLLISFEANAKAI LEEYEQGQYSYKLNILYTQQASAIAESFPNVDAYLLQEKNPIHLIKAVYLMFNSKVII TDNYFLLTSVLNKRKQTKCIQVWHANGSLKKFGLEDITNMQRTKTDIKRFQKVYSSYD YLTVGSEEMANIFKKSFGIKDNQLLKIGVPLTDPYYRENKKKISDTLNIQRKKIILYA PTFRDYNMQSIQLPFTEEQLIHQLKEEYVLFVKLHPAIQNNIDIKYSSDYIKDVSNYA LFDLLMAADILITDYSSVPFEFSILNKPILFYTYDLKLYQQKRGLVDNYLSIIPGRAC YDSESLINEIQTPFNYSKIKVFSDRWNKYSDGNSSQNLLNFIENLIS*" /label="tagB CDS" gene 3087897..3089042 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /label="tagB gene" downshifts 3089030 /Source="Nicolas_upshifts" /id="D1847" /incds=0 /nref=101 /ntot=235 /MaxReadThrough="3.54908" /MaxDrop="5.95551" /score="-3.22062454" /energy="-10" /TU="U2800" /idTUdmin="U2800" /TUdmin="-1169" /isTUend="FALSE" /label="downshifts" promotor_-35 3089084..3089091 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3089106..3089125 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3089116 /Source="Nicolas_upshifts" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="upshifts" CDS 3089162..3090490 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7952180, 16269821; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis)" /protein_id="NP_391458.1" /db_xref="EnsemblGenomes-Gn:BSU35770" /db_xref="EnsemblGenomes-Tr:CAB15594" /db_xref="GOA:P27622" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG10453" /db_xref="UniProtKB/Swiss-Prot:P27622" /translation="MRKKELFDFTNITPKLFTELRVADKTVLQSFNFDEKNHQIYTTQ VASGLGKDNTQSYRITRLSLEGLQLDSMLLKHGGHGTNIGIENRNGTIYIWSLYDKPN ETDKSELVCFPYKAGATLDENSKELQRFSNMPFDHRVTPALDMKNRQLAIRQYDTKNN NNKQWVTIFNLDDAIANKNNPLYTINIPDELHYLQGFFLDDGYLYWYTGDTNSKSYPN LITVFDSDNKIVLQKEITVGKDLSTRYENNFREPEGICMYTNPETGAKSLMVGITSGK EGNRISRIYAYHSYENFMNHVPMLRSPLLKTVGHQDTPPERFQPFIQTFILEYNAQNK KWMVPTSGYLPSYTSNLVRNITINADGNLQVTLNERYISLLHQSIEGDFRLKQKDIRM GSWYFAGGEKSNVLEIGFMKGSTKIRPDDAAISNASRMSIFMIVADKIEV*" /label="tagC CDS" gene 3089162..3090490 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /label="tagC gene" downshifts 3090485 /Source="Nicolas_upshifts" /id="D1848" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.77356" /MaxDrop="4.002" /score="-7.52215775" /energy="-19.3" /TU="NA" /idTUdmin="U2802" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3090546) /Source="Nicolas_upshifts" /id="D1849" /incds=0 /nref=141 /ntot=248 /MaxReadThrough="0.94732" /MaxDrop="5.40128" /score="-0.11635468" /energy="-19.3" /TU="NA" /idTUdmin="U2803" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" SCAR 3090570..3090571 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_002" downshifts 3090594 /Source="Nicolas_upshifts" /id="D1854" /incds=0 /nref=163 /ntot=235 /MaxReadThrough="3.35965" /MaxDrop="5.65658" /score="24.125299" /energy="-9.8" /TU="NA" /idTUdmin="U2809" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3090647..3091888) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /EC_number="3.4.19.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12073126, 12644511, 16689787, 16952838, 26158264, 28664519" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073126, 12644511, 16689787, 16952838, 26158264, 28664519; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-DD-glutamyl hydrolase (PGA depolymerase)" /protein_id="NP_391467.1" /db_xref="EnsemblGenomes-Gn:BSU35860" /db_xref="EnsemblGenomes-Tr:CAB15603" /db_xref="GOA:P96740" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG12535" /db_xref="UniProtKB/Swiss-Prot:P96740" /translation="MNTLANWKKFLLVAVIICFLVPIMTKAEIAEADTSSELIVSEAK NLLGYQYKYGGETPKEGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGD ILFFKKEGSTGTVPTHDALYIGDGQMVHSTQSKGVIITNYKKSSYWSGTYIGARRIAA DPATADVPVVQEAEKYIGVPYVFGGSTPSEGFDCSGLVQYVFQQALGIYLPRSAEQQW AVGEKVAPQNIKPGDVVYFSNTYKTGISHAGIYAGAGRFIQASRSEKVTISYLSEDYW KSKMTGIRRFDNLTIPKENPIVSEATLYVGEVPYKQGGVTPETGFDTAGFVQYVYQKA AGISLPRYATSQYNAGTKIEKADLKPGDIVFFQSTSLNPSIYIGNGQVVHVTLSNGVT ITNMNTSTYWKDKYAGSIRVQ*" /label="pgdS CDS" gene complement(3090647..3091888) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /label="pgdS gene" downshifts complement(3090666) /Source="Nicolas_upshifts" /id="D1855" /incds=0 /nref=228 /ntot=317 /MaxReadThrough="2.27329" /MaxDrop="7.15996" /score="10.2499259" /energy="-9.8" /TU="NA" /idTUdmin="U2812" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3091910..3091928) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3091932) /Source="Nicolas_upshifts" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3091941..3091948) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3092029..3092196) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16267300, 16689787, 20812257, 21357437, 23583563, 25843804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267300, 16689787, 20812257, 21357437, 23583563, 25843804; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor required extrachromosomal elements maintenance" /protein_id="NP_391468.1" /db_xref="EnsemblGenomes-Gn:BSU35870" /db_xref="EnsemblGenomes-Tr:CAB15604" /db_xref="SubtiList:BG12534" /db_xref="UniProtKB/Swiss-Prot:P96739" /translation="MKFVKAIWPFVAVAIVFMFMSAFKFNDQLTDQEKQKIDMEMNKI QQQEEPVNANK*" /label="edmS CDS" gene complement(3092029..3092196) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /label="edmS gene" downshifts complement(3092056) /Source="Nicolas_upshifts" /id="D1856" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="0.6752" /MaxDrop="2.78178" /score="24.9141523" /energy="-14.7" /TU="NA" /idTUdmin="U2812" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" CDS complement(3092211..3093353) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /EC_number="6.3.2.-" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 12644511, 16689787, 19745567, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 12644511, 16689787, 19745567, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (acid resistance)" /protein_id="NP_391469.1" /db_xref="EnsemblGenomes-Gn:BSU35880" /db_xref="EnsemblGenomes-Tr:CAB15605" /db_xref="InterPro:IPR019079" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12533" /db_xref="UniProtKB/Swiss-Prot:P96738" /translation="MKKELSFHEKLLKLTKQQKKKTNKHVFIAIPIVFVLMFAFMWAG KAETPKVKTYSDDVLSASFVGDIMMGRYVEKVTEQKGADSIFQYVEPIFRASDYVAGN FENPVTYQKNYKQADKEIHLQTNKESVKVLKDMNFTVLNSANNHAMDYGVQGMKDTLG EFAKQNLDIVGAGYSLSDAKKKISYQKVNGVTIATLGFTDVSGKGFAAKKNTPGVLPA DPEIFIPMISEAKKHADIVVVQSHWGQEYDNDPNDRQRQLARAMSDAGADIIVGHHPH VLEPIEVYNGTVIFYSLGNFVFDQGWTRTRDSALVQYHLKKNGTGRFEVTPIDIHEAT PAPVKKDSLKQKTIIRELTKDSNFAWKVEDGKLTFDIDHSDKLKSK*" /label="capA CDS" gene complement(3092211..3093353) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /label="capA gene" CDS complement(3093372..3093821) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 15849754, 16689787, 16850406, 19734658" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 15849754, 16689787, 16850406, 19734658; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate amide ligase/translocase subunit" /protein_id="NP_391470.1" /db_xref="EnsemblGenomes-Gn:BSU35890" /db_xref="EnsemblGenomes-Tr:CAB15606" /db_xref="GOA:P96737" /db_xref="InterPro:IPR008338" /db_xref="SubtiList:BG12532" /db_xref="UniProtKB/Swiss-Prot:P96737" /translation="MFGSDLYIALILGVLLSLIFAEKTGIVPAGLVVPGYLGLVFNQP VFILLVLLVSLLTYVIVKYGLSKFMILYGRRKFAAMLITGIVLKIAFDFLYPIVPFEI AEFRGIGIIVPGLIANTIQKQGLTITFGSTLLLSGATFAIMFVYYLI*" /label="capC CDS" gene complement(3093372..3093821) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /label="capC gene" promotor_-35 3093515..3093521 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-35" upshifts 3093529 /Source="Nicolas_upshifts" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="upshifts" promotor_-10 3093535..3093553 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-10" S_feature 3093542..3095751 /Source="Nicolas_S_feature" /locus_tag="new_3699152_3701361" /HighExp="Sw, Salt, dia5, BC, B60, Diami, Lbstat, H2O2, dia15, Gly" /AntisenseName="pgsB" /AntisenseCor="7.6745622610153399E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="0.40410200000000002" /TUshortSig="SigB" /TUshortPSig="0.853" /TUlongSig="NA" /TUlongPSig="NA" /label="S1382" CDS complement(3093836..3095017) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11606194, 11751809, 12644511, 16689787, 19420703, 19734658, 27446033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (ATP-dependentamide ligase)" /protein_id="NP_391471.2" /db_xref="EnsemblGenomes-Gn:BSU35900" /db_xref="EnsemblGenomes-Tr:CAB15607" /db_xref="GOA:P96736" /db_xref="InterPro:IPR008337" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="SubtiList:BG12531" /db_xref="UniProtKB/Swiss-Prot:P96736" /translation="MWLLIIACAVILVIGILEKRRHQKNIDALPVRVNINGIRGKSTV TRLTTGILIEAGYKTVGKTTGTDARMIYWDTPEEKPIKRKPQGPNIGEQKEVMRETVE RGANAIVSECMAVNPDYQIIFQEELLQANIGVIVNVLEDHMDVMGPTLDEIAEAFTAT IPYNGHLVITDSEYTEFFKQKAKERNTKVIIADNSKITDEYLRKFEYMVFPDNASLAL GVAQALGIDEETAFKGMLNAPPDPGAMRILPLISPSEPGHFVNGFAANDASSTLNIWK RVKEIGYPTDDPIIIMNCRADRVDRTQQFANDVLPYIEASELILIGETTEPIVKAYEE GKIPADKLHDLEYKSTDEIMELLKKRMHNRVIYGVGNIHGAAEPLIEKIHEYKVKQLV S*" /label="capB CDS" gene complement(3093836..3095017) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /label="capB gene" promotor_-35 3095731..3095738 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3095753 /Source="Nicolas_upshifts" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3095754..3095773 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3095774) /Source="Nicolas_upshifts" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3095779..3095793) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3095801..3095805) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3095801..3096781 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11750820, 16519689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11750820, 16519689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ribose operon repressor (LacI family, D-ribose)" /protein_id="NP_391472.1" /db_xref="EnsemblGenomes-Gn:BSU35910" /db_xref="EnsemblGenomes-Tr:CAB15608" /db_xref="GOA:P36944" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10876" /db_xref="UniProtKB/Swiss-Prot:P36944" /translation="MATIKDVAGAAGVSVATVSRNLNDNGYVHEETRTRVIAAMAKLN YYPNEVARSLYKRESRLIGLLLPDITNPFFPQLARGAEDELNREGYRLIFGNSDEELK KELEYLQTFKQNHVAGIIAATNYPDLEEYSGMNYPVVFLDRTLEGAPSVSSDGYTGVK LAAQAIIHGKSQRITLLRGPAHLPTAQDRFNGALEILKQAEVDFQVIETASFSIKDAQ SMAKELFASYPATDGVIASNDIQAAAVLHEALRRGKNVPEDIQIIGYDDIPQSGLLFP PLSTIKQPAYDMGKEAAKLLLGIIKKQPLAETAIQMPVTYIGRKTTRKED*" /label="rbsR CDS" gene 3095801..3096781 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /label="rbsR gene" promotor_-35 3096630..3096637 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3096651..3096670 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3096666 /Source="Nicolas_upshifts" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" CDS 3096783..3097664 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /EC_number="2.7.1.15" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 16978644; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribokinase" /protein_id="NP_391473.1" /db_xref="EnsemblGenomes-Gn:BSU35920" /db_xref="EnsemblGenomes-Tr:CAB15609" /db_xref="GOA:P36945" /db_xref="InterPro:IPR002139" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR011877" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG10877" /db_xref="UniProtKB/Swiss-Prot:P36945" /translation="MRNICVIGSCSMDLVVTSDKRPKAGETVLGTSFQTVPGGKGANQ AVAAARLGAQVFMVGKVGDDHYGTAILNNLKANGVRTDYMEPVTHTESGTAHIVLAEG DNSIVVVKGANDDITPAYALNALEQIEKVDMVLIQQEIPEETVDEVCKYCHSHDIPII LNPAPARPLKQETIDHATYLTPNEHEASILFPELTISEALALYPAKLFITEGKQGVRY SAGSKEVLIPSFPVEPVDTTGAGDTFNAAFAVALAEGKDIEAALRFANRAASLSVCSF GAQGGMPTRNEVEELLS*" /label="rbsK CDS" gene 3096783..3097664 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /label="rbsK gene" CDS 3097661..3098056 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /EC_number="5.4.99.62" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 12738765, 21276853; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose pyranase" /protein_id="NP_391474.1" /db_xref="EnsemblGenomes-Gn:BSU35930" /db_xref="EnsemblGenomes-Tr:CAB15610" /db_xref="GOA:P36946" /db_xref="InterPro:IPR007721" /db_xref="InterPro:IPR023064" /db_xref="InterPro:IPR023750" /db_xref="PDB:1OGC" /db_xref="PDB:1OGD" /db_xref="PDB:1OGE" /db_xref="PDB:1OGF" /db_xref="SubtiList:BG10878" /db_xref="UniProtKB/Swiss-Prot:P36946" /translation="MKKHGILNSHLAKILADLGHTDKIVIADAGLPVPDGVLKIDLSL KPGLPAFQDTAAVLAEEMAVEKVIAAAEIKASNQENAKFLENLFSEQEIEYLSHEEFK LLTKDAKAVIRTGEFTPYANCILQAGVLF*" /label="rbsD CDS" gene 3097661..3098056 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /label="rbsD gene" CDS 3098072..3099553 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ATP-binding protein)" /protein_id="NP_391475.1" /db_xref="EnsemblGenomes-Gn:BSU35940" /db_xref="EnsemblGenomes-Tr:CAB15611" /db_xref="GOA:P36947" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015861" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10879" /db_xref="UniProtKB/Swiss-Prot:P36947" /translation="MQIEMKDIHKTFGKNQVLSGVSFQLMPGEVHALMGENGAGKSTL MNILTGLHKADKGQISINGNETYFSNPKEAEQHGIAFIHQELNIWPEMTVLENLFIGK EISSKLGVLQTRKMKALAKEQFDKLSVSLSLDQEAGECSVGQQQMIEIAKALMTNAEV IIMDEPTAALTEREISKLFEVITALKKNGVSIVYISHRMEEIFAICDRITIMRDGKTV DTTNISETDFDEVVKKMVGRELTERYPKRTPSLGDKVFEVKNASVKGSFEDVSFYVRS GEIVGVSGLMGAGRTEMMRALFGVDRLDTGEIWIAGKKTAIKNPQEAVKKGLGFITEN RKDEGLLLDTSIRENIALPNLSSFSPKGLIDHKREAEFVDLLIKRLTIKTASPETHAR HLSGGNQQKVVIAKWIGIGPKVLILDEPTRGVDVGAKREIYTLMNELTERGVAIIMVS SELPEILGMSDRIIVVHEGRISGEIHAREATQERIMTLATGGR*" /label="rbsA CDS" gene 3098072..3099553 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /label="rbsA gene" CDS 3099555..3100523 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (permease)" /protein_id="NP_391476.1" /db_xref="EnsemblGenomes-Gn:BSU35950" /db_xref="EnsemblGenomes-Tr:CAB15612" /db_xref="GOA:P36948" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10880" /db_xref="UniProtKB/Swiss-Prot:P36948" /translation="MKTEQLQTEQKRIHFDGVMQKLGPFLGLFILVIIVSILNPSFLE PLNILNLLRQVAINGLIAFGMTFVILTGGIDLSVGAILALSSALVAGMIVSGVDPVLA IILGCIIGAVLGMINGLLITKGKMAPFIATLATMTVFRGLTLVYTDGNPITGLGTNYG FQMFGRGYFLGIPVPAITMVLAFVILWVLLHKTPFGRRTYAIGGNEKAALISGIKVTR VKVMIYSLAGLLSALAGAILTSRLHSAQPTAGESYELDAIAAVVLGGTSLSGGRGRIV GTLIGVLIIGTLNNGLNLLGVSSFYQLVVKGIVILIAVLLDRKKSA*" /label="rbsC CDS" gene 3099555..3100523 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /label="rbsC gene" CDS 3100535..3101452 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ribose-binding lipoprotein)" /protein_id="NP_391477.1" /db_xref="EnsemblGenomes-Gn:BSU35960" /db_xref="EnsemblGenomes-Tr:CAB15613" /db_xref="GOA:P36949" /db_xref="InterPro:IPR025997" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10881" /db_xref="UniProtKB/Swiss-Prot:P36949" /translation="MKKAVSVILTLSLFLLTACSLEPPQWAKPSNSGNKKEFTIGLSV STLNNPFFVSLKKGIEKEAKKRGMKVIIVDAQNDSSKQTSDVEDLIQQGVDALLINPT DSSAISTAVESANAVGVPVVTIDRSAEQGKVETLVASDNVKGGEMAAAFIADKLGKGA KVAELEGVPGASATRERGSGFHNIADQKLQVVTKQSADFDRTKGLTVMENLLQGHPDI QAVFAHNDEMALGALEAINSSGKDILVIGFDGNKDALASIKDRKLSATVAQQPELIGK LATEAADDILHGKKVQKTISAPLKLETQK*" /label="rbsB CDS" gene 3100535..3101452 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /label="rbsB gene" promotor_-35 3101461..3101467 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3101482..3101500 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3101484 /Source="Nicolas_upshifts" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="upshifts" CDS 3101534..3102070 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall binding enzyme" /protein_id="NP_391478.1" /db_xref="EnsemblGenomes-Gn:BSU35970" /db_xref="EnsemblGenomes-Tr:CAB15614" /db_xref="GOA:P96729" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR036028" /db_xref="SubtiList:BG12530" /db_xref="UniProtKB/Swiss-Prot:P96729" /translation="MNKPTKLFSTLALAAGMTAAAAGGAGTIHAQQPETTVSIDDLYS YPIDSYLVSAEALNVRTKPSASSQKADTLHLGDSLKLISFSNADWAKVKYKNGKTGFV STHYIVKAATTVKTKTKTKVYTSADGKSIKTLPADTSVSFLGWSKTNKGGFDFDWVFV DYGGTTGYMKTKDLHMTK*" /label="ywsB CDS" gene 3101534..3102070 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /label="ywsB gene" downshifts 3102053 /Source="Nicolas_upshifts" /id="D1857" /incds=0 /nref=187 /ntot=255 /MaxReadThrough="5.87246" /MaxDrop="7.38203" /score="26.4284327" /energy="-19" /TU="U2817" /idTUdmin="U2814" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature 3102098..3102208 /Source="Nicolas_S_feature" /locus_tag="new_3707708_3707818" /HighExp="Etha, M9-stat, Sw, M40t90, G150, B60, T0.30H, M0t90, T1.30H, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1383" promotor_-35 3102177..3102183 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3102198..3102209 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3102210 /Source="Nicolas_upshifts" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3102226..3102522 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11782522" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391479.1" /db_xref="EnsemblGenomes-Gn:BSU35980" /db_xref="EnsemblGenomes-Tr:CAB15615" /db_xref="InterPro:IPR024997" /db_xref="SubtiList:BG12529" /db_xref="UniProtKB/Swiss-Prot:P96728" /translation="MDQFEAAYESYKARQTTADQENVPSGKEEIIAVRRNEEDNIIAV KTNTGRELDYPTALSEAKSGKLAHVDVFHKYGRDILRSEPDGIKENNLSELPDF*" /label="ywsA CDS" gene 3102226..3102522 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /label="ywsA gene" S_feature 3102523..3103175 /Source="Nicolas_S_feature" /locus_tag="new_3708133_3708785" /HighExp="Etha, M9-stat, S5, S7, S6, Sw, S8, B60, G150, S4" /AntisenseName="ywrO" /AntisenseCor="-0.23279201478213099" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1384" CDS complement(3102562..3103089) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11782522, 14697229, 17768344; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase (unknown substrate)" /protein_id="NP_391480.1" /db_xref="EnsemblGenomes-Gn:BSU35990" /db_xref="EnsemblGenomes-Tr:CAB15616" /db_xref="GOA:P80871" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12528" /db_xref="UniProtKB/Swiss-Prot:P80871" /translation="MKILVLAVHPHMETSVVNKAWAEELSKHDNITVRDLYKEYPDEA IDVAKEQQLCEEYDRIVFQFPLYWYSSPPLLKKWQDLVLTYGWAFGSEGNALHGKELM LAVSTGSEAEKYQAGGANHYSISELLKPFQATSNLIGMKYLPPYVFYGVNYAAAEDIS HSAKRLAEYIQQPFV*" /label="ywrO CDS" gene complement(3102562..3103089) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /label="ywrO gene" downshifts complement(3102572) /Source="Nicolas_upshifts" /id="D1858" /incds=0 /nref=48 /ntot=208 /MaxReadThrough="3.48831" /MaxDrop="4.56453" /score="1.41593376" /energy="-17.4" /TU="U2819" /idTUdmin="U2821" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3103109..3103128) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3103122) /Source="Nicolas_upshifts" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="upshifts" downshifts 3103133 /Source="Nicolas_upshifts" /id="D1859" /incds=0 /nref=26 /ntot=56 /MaxReadThrough="0.805200000000001" /MaxDrop="4.7199" /score="10.409416" /energy="-6.8" /TU="NA" /idTUdmin="U2817" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3103142..3103149) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3103188) /Source="Nicolas_upshifts" /id="D1860" /incds=0 /nref=20 /ntot=149 /MaxReadThrough="4.85403" /MaxDrop="6.46739" /score="-8.02974492" /energy="-5" /TU="U2821" /idTUdmin="U2821" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3103189..3103956) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /EC_number="4.1.1.5" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7685336, 10972805, 12363365, 17183216, 21531833, 26454865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7685336, 10972805, 12363365, 17183216, 21531833, 26454865; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate decarboxylase" /protein_id="NP_391481.1" /db_xref="EnsemblGenomes-Gn:BSU36000" /db_xref="EnsemblGenomes-Tr:CAB15617" /db_xref="GOA:Q04777" /db_xref="InterPro:IPR005128" /db_xref="SubtiList:BG10472" /db_xref="UniProtKB/Swiss-Prot:Q04777" /translation="MKRESNIQVLSRGQKDQPVSQIYQVSTMTSLLDGVYDGDFELSE IPKYGDFGIGTFNKLDGELIGFDGEFYRLRSDGTATPVQNGDRSPFCSFTFFTPDMTH KIDAKMTREDFEKEINSMLPSRNLFYAIRIDGLFKKVQTRTVELQEKPYVPMVEAVKT QPIFNFDNVRGTIVGFLTPAYANGIAVSGYHLHFIDEGRNSGGHVFDYVLEDCTVTIS QKMNMNLRLPNTADFFNANLDNPDFAKDIETTEGSPE*" /label="alsD CDS" gene complement(3103189..3103956) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /label="alsD gene" CDS complement(3104018..3105730) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /EC_number="2.2.1.6" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972805, 12363365, 17183216, 7685336, 25393087, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972805, 12363365, 17183216, 7685336, 25393087, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate synthase" /protein_id="NP_391482.2" /db_xref="EnsemblGenomes-Gn:BSU36010" /db_xref="EnsemblGenomes-Tr:CAB15618" /db_xref="GOA:Q04789" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012782" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10471" /db_xref="UniProtKB/Swiss-Prot:Q04789" /translation="MTKATKEQKSLVKNRGAELVVDCLVEQGVTHVFGIPGAKIDAVF DALQDKGPEIIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLATGLLTANTEG DPVVALAGNVIRADRLKRTHQSLDNAALFQPITKYSVEVQDVKNIPEAVTNAFRIASA GQAGAAFVSFPQDVVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKLPVVLVG MKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLSRDLEDQYFGRIGLFRNQPGDLLLE QADVVLTIGYDPIEYDPKFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTINH IEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSDRAHPLEIVKELRNAVDDHVT VTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGD GGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNRTSAVDFGNIDIVKYA ESFGATGLRVESPDQLADVLRQGMNAEGPVIIDVPVDYSDNINLASDKLPKEFGELMK TKAL*" /label="alsS CDS" gene complement(3104018..3105730) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /label="alsS gene" promotor_-35 3104629..3104638 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3104652..3104671 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3104652 /Source="Nicolas_upshifts" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3105784..3105803) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3105789) /Source="Nicolas_upshifts" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3105809..3105816 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3105818..3105822) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3105830..3105849 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3105840 /Source="Nicolas_upshifts" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="upshifts" CDS 3105888..3106796 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling alsSD, ictEP expression (LysR family)" /protein_id="NP_391483.1" /db_xref="EnsemblGenomes-Gn:BSU36020" /db_xref="EnsemblGenomes-Tr:CAB15619" /db_xref="GOA:Q04778" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10470" /db_xref="UniProtKB/Swiss-Prot:Q04778" /translation="MELRHLQYFIAVAEELHFGKAARRLNMTQPPLSQQIKQLEEEVG VTLLKRTKRFVELTAAGEIFLNHCRMALMQIGQGIELAQRTARGEQGLLVIGFVGSAT YEFLPPIVREYRKKFPSVKIELREISSSRQQEELLKGNIDIGILHPPLQHTALHIETA QSSPCVLALPKQHPLTSKESITIEDLRDEPIITVAKEAWPTLYMDFIQFCEQAGFRPN IVQEATEYQMVIGLVSAGIGMTFVPSSAKKLFNLDVTYRKMDQIQLNAEWVIAYRKDN HNPLIKHFIHISNCQQTRTKESDAGT*" /label="alsR CDS" gene 3105888..3106796 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /label="alsR gene" promotor_-35 3106864..3106872 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3106874..3107006 /Source="Nicolas_S_feature" /locus_tag="new_3712484_3712616" /HighExp="BT, S8, B36, S7, G/S, S6, Pyr, B60, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.14666000000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.896, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1385" upshifts 3106874 /Source="Nicolas_upshifts" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3106886..3106905 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3107007..3108335 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/H+ antiporter" /protein_id="NP_391484.1" /db_xref="EnsemblGenomes-Gn:BSU36030" /db_xref="EnsemblGenomes-Tr:CAB15620" /db_xref="GOA:O05224" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12527" /db_xref="UniProtKB/Swiss-Prot:O05224" /translation="MLAFFVTMIFIFWRPKGLNEAIPATFGALMVLLCGSVSLADLGE IGTKVTGASVTILATMIMAIALESFGFFYWVAAKLLQQSKGSGIKLFWLTNLLCFLMT IFLNNDGSILITTPILLLVLKYLGLKKHQKAPYLLSGVLIATASSAPIGVSNIVNLIS LKIIGMDLYLHTAMMFVPSMMGLIFMTCLLFMFFYKRLPKSLPDIPGHFQSLRHRRYH PLHSPSAPLPERNQTKIMLFVLAFVFLVRMSLFAASYTGISVPLVAVIGSFILLSWRW IYFKTSPRDLLYKSPWHIFIFAFTMYVLIYGLHNIGFTELLVSYFEPVVSGSLAHATF ASGISTSVFSNLFNNHPALMISTFTLTEMTLNPSTTKIIYLANIIGSDIGSLLLPMGT LATLIWMHILKQHDESISWGEYIKTTIIIIPLTVLFTLTCLYFWISWLFL*" /label="ywrK CDS" gene 3107007..3108335 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /label="ywrK gene" downshifts 3108326 /Source="Nicolas_upshifts" /id="D1861" /incds=0 /nref=16 /ntot=32 /MaxReadThrough="1.63489" /MaxDrop="6.12455" /score="-6.14091334" /energy="-11.9" /TU="NA" /idTUdmin="U2823" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3108392..3109069) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14762006, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391485.1" /db_xref="EnsemblGenomes-Gn:BSU36040" /db_xref="EnsemblGenomes-Tr:CAB15621" /db_xref="InterPro:IPR020139" /db_xref="InterPro:IPR020173" /db_xref="SubtiList:BG12526" /db_xref="UniProtKB/Swiss-Prot:O05223" /translation="MKGLNQFLNTDVEVVISGDTRFVGTLIDIGQDIFVIFDGCNYLY IPLLHLHQINKAKIVTSTEKPFLINPEDPMIEAETQAFSYRNTLNKVKGQFIEVYVTG GRSIHGYVTNVLNDYIVFFSPVFKILFISMHHLKWFTPYSTEQTPYTLDNSQLPVVPS KVPLVRNFEEQIKKNIGELVIFDMGEVPEKVGLLKGVSNNIIELINASGEPVIWKLNH LKTMHLP*" /label="ywrJ CDS" gene complement(3108392..3109069) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /label="ywrJ gene" downshifts complement(3108402) /Source="Nicolas_upshifts" /id="D1862" /incds=0 /nref=14 /ntot=28 /MaxReadThrough="1.74629" /MaxDrop="5.1172" /score="-4.02447737" /energy="-9.5" /TU="NA" /idTUdmin="U2824" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3109129..3110271) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8755863, 10559171, 11737650, 14762006, 19933362, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755863, 10559171, 11737650, 14762006, 19933362, 27185916; Product type s : structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_391486.1" /db_xref="EnsemblGenomes-Gn:BSU36050" /db_xref="EnsemblGenomes-Tr:CAB15622" /db_xref="GOA:P07789" /db_xref="SubtiList:BG10491" /db_xref="UniProtKB/Swiss-Prot:P07789" /translation="MSKRRMKYHSNNEISYYNFLHSMKDKIVTVYRGGPESKKGKLTA VKSDYIALQAEKKIIYYQLEHVKSITEDTNNSTTTIETEEMLDADDFHSLIGHLINQS VQFNQGGPESKKGRLVWLGDDYAALNTNEDGVVYFNIHHIKSISKHEPDLKIEEQTPV GVLEADDLSEVFKSLTHKWVSINRGGPEAIEGILVDNADGHYTIVKNQEVLRIYPFHI KSISLGPKGSYKKEDQKNEQNQEDNNDKDSNSFISSKSYSSSKSSKRSLKSSDDQSSK SGRSSRSKSSSKSSKRSLKSSDYQSSKSGRSSRSKSSSKSSKRSLKSSDYQSSKSSKR SPRSSDYQSSRSPGYSSSIKSSGKQKEDYSYETIVRTIDYHWKRKF*" /label="cotB CDS" gene complement(3109129..3110271) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /label="cotB gene" promotor_-10 complement(3110308..3110327) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3110316) /Source="Nicolas_upshifts" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3110318..3110398) /Source="Nicolas_S_feature" /locus_tag="new_3715928_3716008_c" /HighExp="S6, S7, S8, S5, BT, B36, S4, G/S, Pyr, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1386" promotor_-35 complement(3110341..3110349) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3110399..3111487) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762006, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762006, 25115591, 27185916; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein kinase" /protein_id="NP_391487.1" /db_xref="EnsemblGenomes-Gn:BSU36060" /db_xref="EnsemblGenomes-Tr:CAB15623" /db_xref="GOA:Q45535" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG11791" /db_xref="UniProtKB/Swiss-Prot:Q45535" /translation="MKNQSNLPLYQLFVHPKDLRELKKDIWDDDPVPAVMKVNQKRLD IDIAYRGSHIRDFKKKSYHISFYQPKTFRGAREIHLNAEYKDPSLMRNKLSLDFFSEL GTLSPKAEFAFVKMNGKNEGVYLELESVDEYYLAKRKLADGAIFYAVDDDANFSLMSD LERETKTSLELGYEKKTGTEEDDFYLQDMIFKINTVPKAQFKSEVTKHVDVDKYLRWL AGIVFTSNYDGFVHNYALYRSGETGLFEVIPWDYDATWGRDIHGERMAADYVRIQGFN TLTARILDESEFRKSYKRLLEKTLQSLFTIEYMEPKIMAMYERIRPFVLMDPYKKNDI ERFDREPDVICEYIKNRSQYLKDHLSIL*" /label="cotH CDS" gene complement(3110399..3111487) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /label="cotH gene" S_feature complement(3111488..3111601) /Source="Nicolas_S_feature" /locus_tag="new_3717098_3717211_c" /HighExp="S6, S8, S7, S5, BT, B36, Pyr, G/S, S4, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1387" promotor_-35 3111543..3111552 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3111565..3111584 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3111578 /Source="Nicolas_upshifts" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3111601) /Source="Nicolas_upshifts" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3111605..3111619) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3111628..3111632) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3111628..3112215 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14762006, 15621419, 22720735, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14762006, 15621419, 22720735, 25115591, 27185916; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore morphogenetic protein" /protein_id="NP_391488.1" /db_xref="EnsemblGenomes-Gn:BSU36070" /db_xref="EnsemblGenomes-Tr:CAB15624" /db_xref="GOA:P39801" /db_xref="SubtiList:BG11017" /db_xref="UniProtKB/Swiss-Prot:P39801" /translation="MGHYSHSDIEEAVKSAKKEGLKDYLYQEPHGKKRSHKKSHRTHK KSRSHKKSYCSHKKSRSHKKSFCSHKKSRSHKKSYCSHKKSRSHKKSYRSHKKSRSYK KSYRSYKKSRSYKKSCRSYKKSRSYKKSYCSHKKKSRSYKKSCRTHKKSYRSHKKYYK KPHHHCDDYKRHDDYDSKKEYWKDGNCWVVKKKYK*" /label="cotG CDS" gene 3111628..3112215 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /label="cotG gene" CDS 3111716..3112195 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /function="14.1: Surface structures" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="doubtful CDS (putative in frame frameshift)" /protein_id="YP_009514005.1" /translation="MEKNAVIKSRTALTKNLAAIKNHTALTKNLAVTKNHSVLTKNLA ATKNHTALTRNLAATKNRTVLTKNLAAIKNLTVLTKNLVAIKNLAVLTKNLAATKSLT VLTRKNLAAIRSHAAHTKNLIVPIRNTTKNRTTTATTTKDTMIMTAKKNTGKTAIAG* " /label="doubtful CDS (putative in frame frameshift)" gene 3111716..3112195 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /label="gene" S_feature complement(3112099..3112296) /Source="Nicolas_S_feature" /locus_tag="new_3717709_3717906_c" /HighExp="S5, S6, S4, B60, S3, nit, G/S, SMMPr, S8, ferm" /AntisenseName="cotG" /AntisenseCor="0.60092819988141299" /AntisenseRegPval="-27.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1388" downshifts 3112132 /Source="Nicolas_upshifts" /id="D1863" /incds=1 /nref=1 /ntot=54 /MaxReadThrough="7.80801" /MaxDrop="2.7794" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(3112142) /Source="Nicolas_upshifts" /id="D1864" /incds=1 /nref=3 /ntot=23 /MaxReadThrough="4.99409" /MaxDrop="6.67733" /score="-1.37249416" /energy="-5.2" /TU="U2827" /idTUdmin="U2824" /TUdmin="-3740" /isTUend="FALSE" /label="downshifts" downshifts 3112201 /Source="Nicolas_upshifts" /id="D1865" /incds=0 /nref=41 /ntot=80 /MaxReadThrough="4.68169" /MaxDrop="5.35584" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts 3112280 /Source="Nicolas_upshifts" /id="D1866" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="2.30708" /MaxDrop="3.92552" /score="17.1895651" /energy="-10.7" /TU="NA" /idTUdmin="U2825" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3112295..3112314) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3112301) /Source="Nicolas_upshifts" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3112323..3112330 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3112327..3112336) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3112345..3112364 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3112351 /Source="Nicolas_upshifts" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="upshifts" CDS 3112389..3113006 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /EC_number="1.14.13.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-binding monooxygenase" /protein_id="NP_391489.1" /db_xref="EnsemblGenomes-Gn:BSU36080" /db_xref="EnsemblGenomes-Tr:CAB15625" /db_xref="GOA:O05220" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12525" /db_xref="UniProtKB/Swiss-Prot:O05220" /translation="MYIFQADQLSAKDTYKLLSGTVIPRPIAFVTTLSSGGAVNAAPF SFYNVVSSDPPLLSISVNRTEGRQKDTARNAVENGEFVVHVSDEAIIEDINETAASLR PDESELTRTSLHPVESKAVSVPGIKEARVRFECKLERHITFDNDQGITTADLLIGRVV CFHLDEKVYDAEKGYILTDELKPASRLAGNHYAKLGEEFTLIRPS*" /label="ywrF CDS" gene 3112389..3113006 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /label="ywrF gene" S_feature 3113007..3113107 /Source="Nicolas_S_feature" /locus_tag="new_3718617_3718717" /HighExp="Etha, dia5, Diami, dia15, Lbtran, LBGtran, LPhT, M40t45, M40t90, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1389" downshifts 3113064 /Source="Nicolas_upshifts" /id="D1867" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="4.52989" /MaxDrop="4.48979" /score="-1.9002322" /energy="-14.9" /TU="U2828" /idTUdmin="U2828" /TUdmin="-454" /isTUend="FALSE" /label="downshifts" promotor_-35 3113133..3113142 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3113154..3113169 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3113155 /Source="Nicolas_upshifts" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3113184..3113519 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391490.1" /db_xref="EnsemblGenomes-Gn:BSU36090" /db_xref="EnsemblGenomes-Tr:CAB15626" /db_xref="GOA:O05219" /db_xref="InterPro:IPR025441" /db_xref="SubtiList:BG12524" /db_xref="UniProtKB/Swiss-Prot:O05219" /translation="MTNFWILMLIAITISLASQFFIKKKYGIDKSGWRYKHVSNTHKW IEITLLILFVFSLSFFPVEYLLLLFFIVIDSIRIFMEWHYRPEDKQYMYHIVEVSLMF MLLIYVCTL*" /label="ywrE CDS" gene 3113184..3113519 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /label="ywrE gene" promotor_-10 complement(3113475..3113493) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3113484) /Source="Nicolas_upshifts" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3113508..3113513) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3113518 /Source="Nicolas_upshifts" /id="D1868" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="5.64855" /MaxDrop="3.64569" /score="-1.9002322" /energy="-14.9" /TU="U2829" /idTUdmin="U2828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3113524..3115101) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /EC_number="3.5.1.126" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12823818, 14762019, 19935659, 27303801, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxamate amidohydrolase" /protein_id="NP_391491.1" /db_xref="EnsemblGenomes-Gn:BSU36100" /db_xref="EnsemblGenomes-Tr:CAB15627" /db_xref="GOA:O05218" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="SubtiList:BG12523" /db_xref="UniProtKB/Swiss-Prot:O05218" /translation="MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACL AVVYPHMTGLGGDSFWLTFHQETKAVKVYNGSGRSGKNVTRDVYKGKSAIPLRGIDSA ITVPGMVDSWDAVLKEYGRLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTP YTADIFTRRGKAPVPGERFVQKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSY MTIDDFKAHRGEWAAPVSSDYRGYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSF EYYHVLVEALKKSFLDRDAVLTDPAFADIPLERLLDKRYAKQLAEEIGYLAIPAESRP VGSDTAYAAVIDADGNAVSFIQSLYFEFGSAVTAGDTGILLQNRGSFFSLDENHVNTL EPRKRTFHTLMPAMVCKGGKPKILYGTQGGEGQPQTQTAIITRMLDYGMHPQQAISEP RWVWGRTWGEEYEGLRVEGRFTDKTIQKLKDSGHLVEVVGDYDPLMGQAAAIKVDEEG FLQGGADPRGDGAAVGI*" /label="hpxW CDS" gene complement(3113524..3115101) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /label="hpxW gene" S_feature 3113563..3115274 /Source="Nicolas_S_feature" /locus_tag="new_3719173_3720884" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T-0.40H, T0.0H, Salt" /AntisenseName="ywrD" /AntisenseCor="0.153519829066777" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1390" promotor_-35 3115252..3115259 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3115270..3115289 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3115276 /Source="Nicolas_upshifts" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3115315..3115791 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23989926; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional negative regulator of chromate transport (Lrp/AsnC family)" /protein_id="NP_391492.1" /db_xref="EnsemblGenomes-Gn:BSU36110" /db_xref="EnsemblGenomes-Tr:CAB15628" /db_xref="GOA:O05217" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12522" /db_xref="UniProtKB/Swiss-Prot:O05217" /translation="MSHEYQIPNLVLDETDKQILTILHEEGRISYTDLGKRVDLSRVA VQARINQLIEAGVIEKFTAVINPAKIGIHVSVFFNVEVEPQFLEEVALKLEEEPAVTS LYHMTGPSKLHMHGIFTNDQEMEEFLTKRLYPLRGVVSVDCQMLIKRYKSRMGMKL*" /label="chrS CDS" gene 3115315..3115791 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /label="chrS gene" CDS 3115805..3116398 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit N" /protein_id="NP_391493.1" /db_xref="EnsemblGenomes-Gn:BSU36120" /db_xref="EnsemblGenomes-Tr:CAB15629" /db_xref="GOA:O05216" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12521" /db_xref="UniProtKB/Swiss-Prot:O05216" /translation="MKNHPYRDMTAAMVRTGILGFGGGPSVIPLIRHEAVNKYKWIDD DEFGEILAIANALPGPIATKMAAYLGFKLKGTLGAIVAILAHILPTCLAMVGLFAAVN VLSHSAIVAGMIGAVTPVIAVMLGIMAYEFGQKALKGFGWVTGILFFIIAFIGLQTLQ INPGLVIIIFLAYGAFHFKLKDKITNKHSKDKGMSAS*" /label="chrB CDS" gene 3115805..3116398 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /label="chrB gene" CDS 3116395..3116931 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit C" /protein_id="NP_391494.1" /db_xref="EnsemblGenomes-Gn:BSU36130" /db_xref="EnsemblGenomes-Tr:CAB15630" /db_xref="GOA:O05215" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12520" /db_xref="UniProtKB/Swiss-Prot:O05215" /translation="MISIYLFMAFFIANLLGYGGGPASIPLMFEEVVNRYSWLSNDQF SNMLALANALPGPIATKIAAYVGYSAGGWPGFLIALIATVVPSALALIVLLRIIQRFR QSPVIKGMTLSVQPVIAVMMLILTWQIGADGIKAIGWVQSIVITGISLLAMTKFKMHP AFLIIAAFLYGGLVIPYL*" /label="chrA CDS" gene 3116395..3116931 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /label="chrA gene" downshifts 3116912 /Source="Nicolas_upshifts" /id="D1869" /incds=0 /nref=4 /ntot=90 /MaxReadThrough="0.0513700000000004" /MaxDrop="3.46649" /score="29.5508265" /energy="-8.6" /TU="NA" /idTUdmin="U2829" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(3116958..3117179) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391495.1" /db_xref="EnsemblGenomes-Gn:BSU36140" /db_xref="EnsemblGenomes-Tr:CAB15631" /db_xref="SubtiList:BG12519" /db_xref="UniProtKB/Swiss-Prot:P96727" /translation="MKFLLSVIAGLLILALYLFWKVQPPVWIQVETNSSQLKQSVRMA GTTLQVKHMIKSDAGEETAVISNGISGLK*" /label="ywqO CDS" gene complement(3116958..3117179) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /label="ywqO gene" upshifts 3117126 /Source="Nicolas_upshifts" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3117133..3117134 /Source="Nicolas_upshift_promotors" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3117176..3117721) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391496.1" /db_xref="EnsemblGenomes-Gn:BSU36150" /db_xref="EnsemblGenomes-Tr:CAB15632" /db_xref="GOA:P96726" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLI" /db_xref="SubtiList:BG12518" /db_xref="UniProtKB/Swiss-Prot:P96726" /translation="MKIAVINGGTRSGGNTDVLAEKAVQGFDAEHIYLQKYPIQPIED LRHAQGGFRPVQDDYDSIIERILQCHILIFATPIYWFGMSGTLKLFIDRWSQTLRDPR FPDFKQQMSVKQAYVIAVGGDNPKIKGLPLIQQFEHIFHFMGMSFKGYVLGEGNRPGD ILRDHQALSAASRLLKRSDAI*" /label="ywqN CDS" gene complement(3117176..3117721) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /label="ywqN gene" promotor_-35 3117738..3117745 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3117760..3117779 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3117764 /Source="Nicolas_upshifts" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="upshifts" CDS 3117844..3118725 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391497.1" /db_xref="EnsemblGenomes-Gn:BSU36160" /db_xref="EnsemblGenomes-Tr:CAB15633" /db_xref="GOA:P96725" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12517" /db_xref="UniProtKB/Swiss-Prot:P96725" /translation="MELKQLITFITAAEHVNFTLTAKMLNYAQSSVTSQIKSLEEEIG TPLFERLGKRLILTEAGKTFKSYAQKIIALTEEAKMATNQVRETTGTLKIGATESQCT YRLPPIIKEFKQAFPQVKLIFKPYISNEQAKEQLLQGQLDITFILDVNRMEDALHVES LIQDEIKMVAANDHPFPADLPVTLKDLQNETLLLTEDGCSYRTLFENNLHDSGIYPNK LEFVSIEAIKQCVMAGLGIGILPEMTVKDDIAAGRMKELNWQSDCPVFTQLAWHKDKW MSAPLKAFIDLTRKTFK*" /label="ywqM CDS" gene 3117844..3118725 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /label="ywqM gene" CDS complement(3118810..3119526) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /EC_number="3.1.21.7" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1692969, 22056936, 27530626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1692969, 22056936, 27530626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease V" /protein_id="NP_391498.2" /db_xref="EnsemblGenomes-Gn:BSU36170" /db_xref="EnsemblGenomes-Tr:CAB15634" /db_xref="GOA:P96724" /db_xref="InterPro:IPR007581" /db_xref="PDB:3GA2" /db_xref="SubtiList:BG12516" /db_xref="UniProtKB/Swiss-Prot:P96724" /translation="MKVFDVHKFDMKKEQDFLQVQFNLKNRINLSPTIHPDSINTCAG VDLAYWEQDGEPYGVCCIIVIDADTKEVIEKVHSMGRISVPYVSGFLAFRELPLIIEA AKKLETEPDVFLFDGNGYLHYNHMGVATHAAFFLGKPTIGIAKTYLKIKGCDFVTPEI EVGAYTDIIIDGEVYGRALRTRRDVKPIFLSCGNYIDLDSSYQITMSLINQESRLPIP VRLADLETHVLRTFYQKNHV*" /label="nfi CDS" gene complement(3118810..3119526) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /label="nfi gene" downshifts complement(3118830) /Source="Nicolas_upshifts" /id="D1870" /incds=0 /nref=44 /ntot=216 /MaxReadThrough="1.91774" /MaxDrop="3.62442" /score="12.1019223" /energy="-7.4" /TU="NA" /idTUdmin="U2834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3119536..3120000) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease antitoxin" /protein_id="NP_391499.1" /db_xref="EnsemblGenomes-Gn:BSU36180" /db_xref="EnsemblGenomes-Tr:CAB15635" /db_xref="InterPro:IPR011652" /db_xref="SubtiList:BG12515" /db_xref="UniProtKB/Swiss-Prot:P96723" /translation="MENEYDMKSIKEKGVDFEDLWFSSVSDEILDNPEDENGQPFTGL AYELYPNGQIIYFTKYKNGLAHGLTCEFYENGNKKSEKEYRYGQLHGISIIWFENGRK KSEQQYEHSILISEKNWDEEGNLLNKYEIDTDSPHFEILESRRETHINLGRE*" /label="rttO CDS" gene complement(3119536..3120000) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /label="rttO gene" CDS complement(3119990..3121798) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /EC_number="3.1.-.-" /function="15.8: Toxin production and resistance" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease toxin" /protein_id="NP_391500.1" /db_xref="EnsemblGenomes-Gn:BSU36190" /db_xref="EnsemblGenomes-Tr:CAB15636" /db_xref="GOA:P96722" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR025968" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG12514" /db_xref="UniProtKB/Swiss-Prot:P96722" /translation="MSKVFESKSLIEEAKSRKKQYETLEEQLNTLKKAFQGVADLGDN FKGNGADNIKDFFQGQAEIVDSWLTLVSAQIAFLNGISGDIKDQELNDSYVETSFLDH ELPNGDLKASEIVSAHKEEIDSILSGISDIIDLDMYTLDDYADKMGDAQKIRRDTITA VDKLDESLTTEYQNLESLDNAVLTKYSVLMQATSNGKSASPMYYDKKAFHSNEVYKSV IEVENQGTTYIDAKTQQAEARRLQEKAEEEANKPWYEKTWDGVCNFTGEVTGYYDYKR ATEGVDPVTGEKLSTAERVTAGAMAAAGFIPVVGWAGRAFKGGKAIYKTGKAAIAAEH ALDAYKTGKSLDILKMTEMGAYGLVASNGFSEAVTGRDMFGNKVSEEKRKQGALEAIT IIGGAGLAHYFDRLYQKNAPYVNKVSNESLISNIAKTTEEKQTRLQYLRNKHGVLSKE DLHHRINLRAEVLNELSRIKSSGLTKKQRGPAVAGVLDKKTGNYYFGINNIDGKPPKV LHPLIHDRIVNMPTELKEGYIKTSGAGSHAEVNALNEALLQRPDADLKDLMVYVVSAR KINKKMPEGVPMPRCPHCEYITQNTNYIPEALKYGK*" /label="rttN CDS" gene complement(3119990..3121798) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /label="rttN gene" CDS complement(3121817..3122077) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391501.1" /db_xref="EnsemblGenomes-Gn:BSU36200" /db_xref="EnsemblGenomes-Tr:CAB15637" /db_xref="InterPro:IPR020299" /db_xref="SubtiList:BG12513" /db_xref="UniProtKB/Swiss-Prot:P96721" /translation="MSEIKLKYDTVIKTLDSVKDALADVSIGAAGSNGKNSLDYTKKY HEREENIKTMLGDYKKAVQKNIEDTKDNVDSLKEQDEAIAVK*" /label="ywqI CDS" gene complement(3121817..3122077) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /label="ywqI gene" CDS complement(3122087..3122509) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15101989" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391502.1" /db_xref="EnsemblGenomes-Gn:BSU36210" /db_xref="EnsemblGenomes-Tr:CAB15638" /db_xref="InterPro:IPR020326" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG12512" /db_xref="UniProtKB/Swiss-Prot:P96720" /translation="MGYESMLADIKSSLNGKISDVEDKIEKLKKAKKDIDTLQEEAIT EIKEIVKPELGKHWTGTKADDFDKGREEAKSEASKIVNDKYNEYMASINGKIFDLEWD KAKYASELFIANGAADLLKKGEEFAEEVGNTISKLKWW*" /label="ywqH CDS" gene complement(3122087..3122509) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /label="ywqH gene" S_feature complement(3122510..3122592) /Source="Nicolas_S_feature" /locus_tag="new_3728120_3728202_c" /HighExp="T2.30H, T4.0H, T5.0H, T3.0H, T3.30H, T1.30H, T2.0H, S4, T-0.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1391" promotor_-10 complement(3122584..3122603) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3122592) /Source="Nicolas_upshifts" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3122616..3122623) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3122726..3122851) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514006.1" /translation="MTKSDMADQMKNINMNNKLSAERGRSTTSASFKCLYNYDIR*" /label="hypothetical protein CDS" gene complement(3122726..3122851) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /label="gene" S_feature complement(3122769..3122900) /Source="Nicolas_S_feature" /locus_tag="new_3728379_3728510_c" /HighExp="HiOs, BI, M9-tran, T-2.40H, MG 150, Sw, M9-exp, S1, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19133600000000001" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1392" downshifts complement(3122812) /Source="Nicolas_upshifts" /id="D1871" /incds=0 /nref=29 /ntot=208 /MaxReadThrough="3.03928" /MaxDrop="3.47153" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2835" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3122901..3123686) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391503.1" /db_xref="EnsemblGenomes-Gn:BSU36220" /db_xref="EnsemblGenomes-Tr:CAB15639" /db_xref="InterPro:IPR015315" /db_xref="InterPro:IPR035948" /db_xref="PDB:1PV5" /db_xref="SubtiList:BG12511" /db_xref="UniProtKB/Swiss-Prot:P96719" /translation="MNHLPEKMRPYRDLLEKSAKEYVKLNVRKGKTGRYDSKIAGDPY FPKHETYPTDENGQPMKLLAQINFSHIPQLDGYPSSGILQFYISVHDDVYGLNFDDRC EQKNFRVIYFENIVENDDELVSDFSFIGTGECDFPILSEAAVEPVKSSEWVLPTDFQF EQYTGMETMEFFGQFGEDEEDIYNELAENGFGHKIGGYASFTQHDPREYAYKEHTIML LQIDSDDDIDSMWGDVGIANFFITPEDLRKKDFSNVLYNWDCS*" /label="ywqG CDS" gene complement(3122901..3123686) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /label="ywqG gene" S_feature complement(3123687..3123802) /Source="Nicolas_S_feature" /locus_tag="new_3729297_3729412_c" /HighExp="HiOs, T-1.40H, T-2.40H, T-3.40H, M9-tran, MG 150, SMM, GM 150, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1393" promotor_-10 complement(3123795..3123814) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3123802) /Source="Nicolas_upshifts" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3123828..3123835) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3123878..3125200) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 15866923, 16415592" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 15866923, 16415592; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose dehydrogenase" /protein_id="NP_391504.1" /db_xref="EnsemblGenomes-Gn:BSU36230" /db_xref="EnsemblGenomes-Tr:CAB15640" /db_xref="GOA:P96718" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12510" /db_xref="UniProtKB/Swiss-Prot:P96718" /translation="MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGIS PIFEPGLEELMRKNTADGRLNFETSYEKGLAQADIIFIAVGTPQKSDGHANLEQITDA AKRIAKHVKRDTVVVTKSTVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIY DTFHGDRIVIGTADEKTANTLEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFI NEISNICEKVGADIEAVAYGMGQDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVE HDFELLKSVIKVNNNQQAMLVDKALNRLGGVTGKTIALLGLSFKPNTDDMREAPSIVI ADRLAALDARIRAYDPIAVSHAKHVLPQAVEYKETIEEAVKGSDAVMILTDWADIKQF PLAAYQDLMETPLIFDGRNCYTLDEALAAGVEYYSVGRKAVVPSGAIQ*" /label="uglF CDS" gene complement(3123878..3125200) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /label="uglF gene" downshifts complement(3123890) /Source="Nicolas_upshifts" /id="D1872" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.29767" /MaxDrop="6.20721" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2836" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3125234) /Source="Nicolas_upshifts" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3125236..3125361) /Source="Nicolas_S_feature" /locus_tag="new_3730846_3730971_c" /HighExp="dia15, H2O2, Diami, dia5, LBGstat, Paraq, LBGexp, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13453899999999999" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1394" promotor_-10 complement(3125236..3125254) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3125270..3125275) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3125341..3125360) /Source="Nicolas_upshift_promotors" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3125361) /Source="Nicolas_upshifts" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3125395..3126159) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15866923, 16415592, 16549871, 21605684, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15866923, 16415592, 16549871, 21605684, 27148221; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine-phosphatase" /protein_id="NP_391505.1" /db_xref="EnsemblGenomes-Gn:BSU36240" /db_xref="EnsemblGenomes-Tr:CAB15641" /db_xref="GOA:P96717" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR016667" /db_xref="PDB:3QY6" /db_xref="PDB:3QY7" /db_xref="SubtiList:BG12509" /db_xref="UniProtKB/Swiss-Prot:P96717" /translation="MIDIHCHILPAMDDGAGDSADSIEMARAAVRQGIRTIIATPHHN NGVYKNEPAAVREAADQLNKRLIKEDIPLHVLPGQEIRIYGEVEQDLAKRQLLSLNDT KYILIEFPFDHVPRYAEQLFYDLQLKGYIPVIAHPERNREIRENPSLLYHLVEKGAAS QITSGSLAGIFGKQLKAFSLRLVEANLIHFVASDAHNVKTRNFHTQEALYVLEKEFGS ELPYMLTENAELLLRNQTIFRQPPQPVKRRKLFGFF*" /label="ptpZ CDS" gene complement(3125395..3126159) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /label="ptpZ gene" downshifts complement(3126178) /Source="Nicolas_upshifts" /id="D1873" /incds=0 /nref=4 /ntot=152 /MaxReadThrough="3.17433" /MaxDrop="3.31415" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(3126212..3126925) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /EC_number="2.7.10.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maintenance protein tyrosine kinase involved in biofilm formation" /protein_id="NP_391506.1" /db_xref="EnsemblGenomes-Gn:BSU36250" /db_xref="EnsemblGenomes-Tr:CAB15642" /db_xref="GOA:P96716" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12508" /db_xref="UniProtKB/Swiss-Prot:P96716" /translation="MALRKNRGSRMQRNVIAMTEPKSLNSEQYRTIRTNIEFASVDRQ MKSVMITSACPGEGKSTTAANLAVVFAQQGKKVLLIDADLRKPTVHTAFFLENTVGLT SVLLKKSSMEQAVQASNEKHLDVLTSGPIPPNPAELLSSKWMKELAYEACAAYDMVIF DTPPILAVADAQILGNVADGSVLVISSGKTEKEQAAKAKEALATCKSKLLGAIMNGKK LSKHSEYGYYGTKDNFMQK*" /label="ptkA CDS" gene complement(3126212..3126925) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /label="ptkA gene" downshifts complement(3126229) /Source="Nicolas_upshifts" /id="D1874" /incds=0 /nref=10 /ntot=157 /MaxReadThrough="4.4352" /MaxDrop="4.08842" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-381" /isTUend="FALSE" /label="downshifts" CDS complement(3126915..3127661) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 23939619, 24493247, 26283769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 23939619, 24493247, 26283769; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of PtkA protein tyrosine kinase activity; modulation of biofilm formation" /protein_id="NP_391507.1" /db_xref="EnsemblGenomes-Gn:BSU36260" /db_xref="EnsemblGenomes-Tr:CAB15643" /db_xref="GOA:P96715" /db_xref="InterPro:IPR003856" /db_xref="InterPro:IPR032807" /db_xref="SubtiList:BG12507" /db_xref="UniProtKB/Swiss-Prot:P96715" /translation="MGESTSLKEILSTLTKRILLIMIVTAAATAAGGLISFFALTPIY ENSTQILVNQSKNERKEVQFNDVQTNLQLINTYNVIIKSPAILDEVIKEMGLSMTSQE LNDKITVSSEQDSQVVNISVRDENAETAAHIANTIASVFQDKITSIMNVDNVSILSKA EVSEHPSPVSPKPLLNIAIAFAAGLAGSIGLAFLLEHLDNTIKSEEQLESLLDIPVLG TVSTIANEQKTAKTLQGFQSEKTGSGHFGA*" /label="tkmA CDS" gene complement(3126915..3127661) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /label="tkmA gene" promotor_-10 complement(3127693..3127712) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3127705) /Source="Nicolas_upshifts" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3127729..3127732) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3127895..3128038) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097792.1" /db_xref="EnsemblGenomes-Gn:BSU36269" /db_xref="EnsemblGenomes-Tr:CAX52703" /db_xref="UniProtKB/Swiss-Prot:C0H3S3" /translation="MSEKKLNQEEFLKILMHAHEIGEQSSEMTTKEMLENLISHIKNG YAT*" /label="ywzD CDS" gene complement(3127895..3128038) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /label="ywzD gene" downshifts complement(3127916) /Source="Nicolas_upshifts" /id="D1875" /incds=0 /nref=221 /ntot=264 /MaxReadThrough="2.76798" /MaxDrop="8.13076" /score="15.8630799" /energy="-9.3" /TU="U2839" /idTUdmin="U2841" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3128039..3128124) /Source="Nicolas_S_feature" /locus_tag="new_3733649_3733734_c" /HighExp="S6, S8, S7, MG-0.2, S5, M9-stat, MG-0.1, MG 25, T0.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD, SigK" /TUshortPSig="0.275, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1395" misc_feature complement(3128114..3128125) /Source="Nicolas_upshift_promotors" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3128124) /Source="Nicolas_upshifts" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3128126..3128356) /Source="Nicolas_S_feature" /locus_tag="new_3733736_3733966_c" /HighExp="S6, S8, S7, S5, BT, Cold, LBGstat, LPhT, Pyr, C30" /AntisenseName="ywqB" /AntisenseCor="3.4267833233812203E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1396" promotor_-35 3128163..3128167 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3128183..3128202 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3128192 /Source="Nicolas_upshifts" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="upshifts" CDS 3128242..3129852 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative replication initiation protein" /protein_id="NP_391508.2" /db_xref="EnsemblGenomes-Gn:BSU36270" /db_xref="EnsemblGenomes-Tr:CAB15644" /db_xref="GOA:P96714" /db_xref="InterPro:IPR007527" /db_xref="SubtiList:BG12506" /db_xref="UniProtKB/Swiss-Prot:P96714" /translation="MLQNMISKDDVLASAEQLKELLPYNEENVQLIKKALILYRQDSV YRLQAVSPTEVTAYVQDVVPVRVTLNLFVIVKSGCSCPSGRICRHMLAVFLYVYAMFE RVGTFTEYWLEREKLEESKELVRRQFQEKVLPNEESLSSWLAFFDSEFSLWQARTPEG SQNMQGLYYGYLSALKKHAPNKPELKSLYQIHSAIAVWLRMFTLIEAGKLNPEQDFYS LNPYVEQLMDTIYSSIDKLKTYALSFALDPFLDKTPDVIRHLLLKEEIFQYERIRVFG EIWSALLSRPKWVAREQEILKKEAGRRFSPELQFGRLHLEFLQKNDDVIFEEADQFPP EALPYTFQWLSEMTAKKDWKRLKTWYQQIEPIAMGYTKLDKPFKEIRDVIGELFLLLN AYVQQTNDQALFERFAAGCLPYTFTEYSHHLYEKKRYAEWIEIHSLVGFSINEMDKMM LKEIAASDPEALIPAYHREVAFFIDQKNRSSYKEAARYLKKLRTLYKKAKKQKVWERY IQLLSSHYKRLRALQEELQKGKLIDGES*" /label="ywqB CDS" gene 3128242..3129852 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /label="ywqB gene" promotor_-10 complement(3128344..3128362) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3128356) /Source="Nicolas_upshifts" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3128358..3128532) /Source="Nicolas_S_feature" /locus_tag="new_3733968_3734142_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, B60, C30" /AntisenseName="ywqB" /AntisenseCor="-0.10880748846525" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1397" promotor_-35 complement(3128376..3128383) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3128519..3128538) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3128532) /Source="Nicolas_upshifts" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3128552..3128560) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3129839..3132607 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9507009, 9614128, 11751638, 17913745, 19282450; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATPase involved in RNA remodelling DNA recombination and repair" /protein_id="NP_391509.1" /db_xref="EnsemblGenomes-Gn:BSU36280" /db_xref="EnsemblGenomes-Tr:CAB15645" /db_xref="GOA:P94593" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR022138" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12505" /db_xref="UniProtKB/Swiss-Prot:P94593" /translation="MASLKEILIHVEQMEDGSFTLSAFDENEQPLPYSHMKKHLFQWH ESSFYGTFLEDVSFIGTTAVLLSPWMTVELLGKNSFNSFSSVQLTEETEPLIEAASTI YEFIADGDFMPDYDAWTNGVFRWKDRDNILEGFTAEWFSAAVQDYIQYDDDLREKWEH IKEKSPAVTTFRGHFLDEEDFLEGIGWIDDQSPFTVGLRLNEPDFDGDEWKIEMFLRD KKSGAVEFFDGLKSLKKSWQAYSDKIAREQDRFHRTVPWLSFDSGTTLISEEEAWIFL SEASETLVDMGVEILLPSWWQIVRDSNMMLKAKVSSSPRGESFVGMNALLDFNWRFAT NGIELTEAEFNELVASNRRLVNIRGQWVKIDPQFIKQMKRLMEKAESEGLHMSDILAR ELMDQQDGGLEDSDLIDTSAFAGIQFDLSKQLRSLIRKLTAAENLPEHKVSPSFKGTL RPYQKYGMNWLLFLRESGFGACLADDMGLGKTIQMIAYFLHVKESGRQKTPHLIIAPT SVLGNWQRELQTFAPDLSVALHYGPRRPKGDDFAAHYENADVVLTSYGLSHADTEELS SVTWNTICLDEAQNIKNAHTKQSRAIRKLKGLHHIALSGTPMENRLTELWSIFDFMNK GYLGSLTGFHKRYVLPIEKDRDEKRIGQLQQLIRPFLLRRTKRDEEVALNLPEKLEEK EFIPLSAEQASLYEQLVKDTFDHMTSLTGMQRKALILSMLGRLKQICDHPALYLKEEQ TELLAGRSVKLEKLLELMTAIRAQNESCLIFTQYIQMGNMMKRLLEKTFGEPVQFLNG SLSKQERDTLVEKFQRKEYPTLILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATD RAYRIGQERFVHVHKMITTGTIEEKIDVMLESKQTLNDQIIQSENWITELSTQELEEL FTLSATAQ*" /label="hepA CDS" gene 3129839..3132607 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /label="hepA gene" downshifts complement(3132656) /Source="Nicolas_upshifts" /id="D1876" /incds=0 /nref=9 /ntot=202 /MaxReadThrough="1.80101" /MaxDrop="4.14573" /score="30.708119" /energy="-14.4" /TU="U2843" /idTUdmin="U2844" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3132733..3133590) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25848029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase of unidentified specificity (possibly promiscuous)" /protein_id="NP_391510.1" /db_xref="EnsemblGenomes-Gn:BSU36290" /db_xref="EnsemblGenomes-Tr:CAB15646" /db_xref="GOA:P94592" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:1NRW" /db_xref="SubtiList:BG12504" /db_xref="UniProtKB/Swiss-Prot:P94592" /translation="MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRA HFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYE VFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQEL FEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQAL KRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHG VAHMMKHLL*" /label="ywpJ CDS" gene complement(3132733..3133590) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /label="ywpJ gene" CDS complement(3133596..3134372) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11491085" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11491085; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (glucose repression ofcatabolic operons)" /protein_id="NP_391511.1" /db_xref="EnsemblGenomes-Gn:BSU36300" /db_xref="EnsemblGenomes-Tr:CAB15647" /db_xref="GOA:P94591" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12503" /db_xref="UniProtKB/Swiss-Prot:P94591" /translation="MYQEERLVAILDFLKQHNRITTEQICTLLQVSRDTARRDLVKLE EQNAIIRTRGGAILPTVHQKIQSYSGRLKTVSEEKNKIGRLAASLIHDGDRVILDAST TVQACAKHLNAVDCTVITNSINLADVLSDKEGIEIYLLGGKLEKEHRFLYGSSVIEKL SSYHVDKALIGVVGISEHGITIAHEEDGMVKRKMIQQAKQVIALADHSKLGSTSFYQY AELNEIDLLITDRLPNQAFCDLLDRNGVELLVTEQDEGKD*" /label="glcR CDS" gene complement(3133596..3134372) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /label="glcR gene" promotor_-10 complement(3134398..3134417) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3134420) /Source="Nicolas_upshifts" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3134422..3134494) /Source="Nicolas_S_feature" /locus_tag="new_3740032_3740104_c" /HighExp="C30, GM 150, T-4.40H, G/S, C90, S2, T-5.40H, T-3.40H, T-2.40H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1398" promotor_-35 complement(3134432..3134439) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3134496..3134595) /Source="Nicolas_S_feature" /locus_tag="new_3740106_3740205_c" /HighExp="HiOs, S2, T-3.40H, T0.30H, C90, G/S, T1.0H, T0.0H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1399" downshifts complement(3134539) /Source="Nicolas_upshifts" /id="D1877" /incds=0 /nref=221 /ntot=258 /MaxReadThrough="3.81096" /MaxDrop="7.17295" /score="-7.00620083" /energy="-7.5" /TU="U2844" /idTUdmin="U2846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(3134596..3134937) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762004, 16009133, 16549871, 17630974, 25138221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762004, 16009133, 16549871, 17630974, 25138221; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391512.2" /db_xref="EnsemblGenomes-Gn:BSU36310" /db_xref="EnsemblGenomes-Tr:CAB15648" /db_xref="GOA:C0SPB6" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="PDB:3VDY" /db_xref="SubtiList:BG12502" /db_xref="UniProtKB/Swiss-Prot:C0SPB6" /translation="MFNQVMLVGRLTKDPDLRYTSAGAAVAHVTLAVNRSFKNASGEI EADYVNCTLWRKTAENTALYCQKGSLVGVSGRIQTRSYENEEGVNVYVTEVLADTVRF MDPKPREKAAD*" /label="ssbB CDS" gene complement(3134596..3134937) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /label="ssbB gene" promotor_-10 complement(3134959..3134978) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3134978) /Source="Nicolas_upshifts" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3134992..3134999) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3135014..3135397) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="interaction partner of DynA" /protein_id="NP_391513.1" /db_xref="EnsemblGenomes-Gn:BSU36320" /db_xref="EnsemblGenomes-Tr:CAB15649" /db_xref="SubtiList:BG12501" /db_xref="UniProtKB/Swiss-Prot:P94589" /translation="MNQFRLKEIYIDGVPSESHLIQKEVTYMLSRKEVFEVHLNKKGR ISFLYETQDGMEQYKIKLSMPEKKLSFQWFAWDGSSYVRMNTQNWLTKQIFFRFLKST YFFKGKKQKMFLAEGKMKTKDKNRG*" /label="ywpG CDS" gene complement(3135014..3135397) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /label="ywpG gene" promotor_-10 complement(3135419..3135438) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-10" misc_feature 3135426..3135445 /Source="Nicolas_upshift_promotors" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3135430 /Source="Nicolas_upshifts" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3135439) /Source="Nicolas_upshifts" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="upshifts" promotor_-35 complement(3135453..3135460) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-35" misc_feature 3135520..3135539 /Source="Nicolas_upshift_promotors" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3135523 /Source="Nicolas_upshifts" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3135572) /Source="Nicolas_upshifts" /id="D1878" /incds=0 /nref=2 /ntot=169 /MaxReadThrough="0.85282" /MaxDrop="4.02798" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2846" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS 3135572..3135982 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25663006" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391514.1" /db_xref="EnsemblGenomes-Gn:BSU36330" /db_xref="EnsemblGenomes-Tr:CAB15650" /db_xref="InterPro:IPR025573" /db_xref="SubtiList:BG12500" /db_xref="UniProtKB/Swiss-Prot:P94588" /translation="MKTFKLVDLNVERVDKEEQSIEQFPLIDGLIINKEDGENHWLIE ALVQKEHLSFFEQLQNSQSEAKVFVTITKKSNRPAQLTAAVKNIVKLEESIQVLLYGQ MVTRKQQGTETILESLVKEGYTGTKLIEAFKQKL*" /label="ywpF CDS" gene 3135572..3135982 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /label="ywpF gene" S_feature 3135983..3136066 /Source="Nicolas_S_feature" /locus_tag="new_3741593_3741676" /HighExp="BC, LBGtran, T3.30H, Etha, T2.0H, Lbtran, M9-stat, T3.0H, dia5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1400" downshifts 3136024 /Source="Nicolas_upshifts" /id="D1879" /incds=0 /nref=214 /ntot=260 /MaxReadThrough="1.83981" /MaxDrop="6.19197" /score="18.4023831" /energy="-14" /TU="NA" /idTUdmin="U2847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3136122..3136430) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 21800427, 21906378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sortase" /protein_id="NP_391515.1" /db_xref="EnsemblGenomes-Gn:BSU36340" /db_xref="EnsemblGenomes-Tr:CAB15651" /db_xref="GOA:P94587" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG12499" /db_xref="UniProtKB/Swiss-Prot:P94587" /translation="MRRDQKMGEGNYPLAGHHLKQKNLLFGPLENIKTGAQIVITDFK KDYIYSVTSKDIISEMDADVVEETNKKEITLITCDKAVKTEGRLVVKGELVDSFGHTN *" /label="ywpE CDS" gene complement(3136122..3136430) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /label="ywpE gene" downshifts complement(3136123) /Source="Nicolas_upshifts" /id="D1880" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="0.11027" /MaxDrop="2.8132" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2849" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS 3136774..3137610 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16740923; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative two-component sensor histidine kinase" /protein_id="NP_391516.1" /db_xref="EnsemblGenomes-Gn:BSU36350" /db_xref="EnsemblGenomes-Tr:CAB15652" /db_xref="GOA:P94586" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12498" /db_xref="UniProtKB/Swiss-Prot:P94586" /translation="MKIRERFSMVDLPVLIITAAIIGHDKYKAFHAGANDILQKPYHY SEFMARIQNLIMMKHTANQATRMEMAFLQSQIKPHFLYNVLNTIISLTHLDIEKAREV TEEFTNYLRMSFDFQNTSAISSFRHELSIINSYLSIEKTRFSNRLEVLFDIDEDIDFI LPPLMIQPLVENAVLHGVSKKRGGGWIKLTAKKQSKNEYHIKVEDNGPGITPEKQIDL LSTDFDRSVGLKNINQRLKHFCGSELMISSTPDAGTSVSMLIHLAETTGSPKELKDTE RT*" /label="ywpD CDS" gene 3136774..3137610 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /label="ywpD gene" promotor_-35 3136990..3136997 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3137012..3137031 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3137015 /Source="Nicolas_upshifts" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3137609 /Source="Nicolas_upshifts" /id="D1881" /incds=0 /nref=13 /ntot=132 /MaxReadThrough="0.11837" /MaxDrop="3.37937" /score="9.16906941" /energy="-8.6" /TU="NA" /idTUdmin="U2848" /TUdmin=154 /isTUend="FALSE" /label="downshifts" CDS complement(3137657..3138049) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /function="16.1: Circulate" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12948773, 15063854, 15165739, 16897034, 22685134, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12948773, 15063854, 15165739, 16897034, 22685134, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="large conductance mechanosensitive channel protein" /protein_id="NP_391517.1" /db_xref="EnsemblGenomes-Gn:BSU36360" /db_xref="EnsemblGenomes-Tr:CAB15653" /db_xref="GOA:P94585" /db_xref="InterPro:IPR001185" /db_xref="InterPro:IPR019823" /db_xref="InterPro:IPR036019" /db_xref="SubtiList:BG12497" /db_xref="UniProtKB/Swiss-Prot:P94585" /translation="MWNEFKAFAMRGNIVDLAIGVVIGGAFGKIVTSLVNDIIMPLVG LLLGGLDFSGLSFTFGDAVVKYGSFIQTIVNFLIISFSIFIVIRTLNGLRRKKEAEEE AAEEAVDAQEELLKEIRDLLKQQAKSPE*" /label="mscL CDS" gene complement(3137657..3138049) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /label="mscL gene" downshifts complement(3137663) /Source="Nicolas_upshifts" /id="D1882" /incds=0 /nref=216 /ntot=255 /MaxReadThrough="2.23487" /MaxDrop="6.5103" /score="28.9904077" /energy="-11.4" /TU="NA" /idTUdmin="U2849" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3138122..3138547) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /EC_number="4.2.1.59" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8910376, 12682299, 15194690, 15371447, 18093984, 22580319, 23322253, 27874013; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacyl-[acyl carrier protein] dehydratase" /protein_id="NP_391518.2" /db_xref="EnsemblGenomes-Gn:BSU36370" /db_xref="EnsemblGenomes-Tr:CAB15654" /db_xref="GOA:P94584" /db_xref="InterPro:IPR010084" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12496" /db_xref="UniProtKB/Swiss-Prot:P94584" /translation="MLDTQQIKEIIPHRYPFLLVDRITEVEEGKRAKGYKNVTANEEF FNGHFPQYPVMPGVLIVEALAQVGAVAMLIKEENRGRLAFFAGIDNCRFKKQVKPGDQ LHLEVEIIRARGTIGRGKGVATVDGEVVCEVELTFALGE*" /label="fabZ CDS" gene complement(3138122..3138547) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /label="fabZ gene" promotor_-10 complement(3138608..3138627) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3138624) /Source="Nicolas_upshifts" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3138626..3138710) /Source="Nicolas_S_feature" /locus_tag="new_3744236_3744320_c" /HighExp="Diami, dia5, Cold, dia15, H2O2, C30, Etha, Oxctl, Paraq, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigD, SigA" /TUlongPSig="0.999, 0.837" /label="S1401" promotor_-35 complement(3138642..3138649) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3138689 /Source="Nicolas_upshifts" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3138692..3138711 /Source="Nicolas_upshift_promotors" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3138702..3138721) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-10" upshifts complement(3138710) /Source="Nicolas_upshifts" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="upshifts" S_feature complement(3138712..3139796) /Source="Nicolas_S_feature" /locus_tag="new_3744322_3745406_c" /HighExp="Cold, C30, Lbstat, Glucon, Glu, Paraq, Pyr, H2O2, Fru, C90" /AntisenseName="rapD" /AntisenseCor="5.8390464430913601E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.837" /label="S1402" promotor_-35 complement(3138735..3138740) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-35" CDS 3138739..3139803 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391519.1" /db_xref="EnsemblGenomes-Gn:BSU36380" /db_xref="EnsemblGenomes-Tr:CAB15655" /db_xref="GOA:P94583" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11967" /db_xref="UniProtKB/Swiss-Prot:P94583" /translation="MISKFIEKRMLNMLDEWYSAMSKRKMNHVCTLKEKIDQHLPKIK KNTKLWMRYQLFQARHQLLFENQNGLDSLFDGLYGLEDKMDDELKYYLYFFSGLYEMV KTAPKHAVHHFKKAEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIY LHQFGYIKKVITCKLLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDENLLCHAYYNLG FLKATEKKDQEALLYFRKVLKNQEFEMNSPVSYLHCVYESVRALFKTGNITEAKAVLQ KGKELSEKVDIQTIYLKLKTLEALYTSAEDPYEQLLEYVLELEKIEAWVDLEVLLEDI TEYYKKKDDFEKAAFFIMRG*" /label="rapD CDS" gene 3138739..3139803 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /label="rapD gene" S_feature 3139804..3140688 /Source="Nicolas_S_feature" /locus_tag="new_3745414_3746298" /HighExp="M9-stat, T4.0H, T2.0H, T3.30H, T2.30H, T3.0H, T1.30H, T5.0H, T1.0H, T0.30H" /AntisenseName="flhP" /AntisenseCor="-0.32116112580252298" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1403" CDS complement(3139826..3140635) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-basal body accessory protein" /protein_id="NP_391520.2" /db_xref="EnsemblGenomes-Gn:BSU36390" /db_xref="EnsemblGenomes-Tr:CAB15656" /db_xref="GOA:P39753" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10918" /db_xref="UniProtKB/Swiss-Prot:P39753" /translation="MLRSMLTASTTLNQLQQQIDTISSNLSNSNTTGYKAKDTNFSEL VRQQFDQVDEKNEEVAKARKTPPGLRLGVGAMMSSRLVSDQGSIQKTDRDLDIAFTSP YQYLQVNVNGNRQYTRDGALYVTPSAANANQLQLVTGNGYPVLDENGNTVNIDSSMKN ITINKNGTLTASDGNAVQRFNLGVVQVNNPQELKSEGNNLFSIDNAAAFEELNGANRQ NIGMQQGSLEMSNVDISEQMTDLITSQRSYQLNSRTITMGDQMLGLINSVR*" /label="flhP CDS" gene complement(3139826..3140635) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /label="flhP gene" downshifts complement(3139841) /Source="Nicolas_upshifts" /id="D1883" /incds=0 /nref=174 /ntot=256 /MaxReadThrough="4.65461" /MaxDrop="5.56507" /score="8.59904552" /energy="-7.4" /TU="U2853" /idTUdmin="U2854" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3140669..3141481) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1905667, 16621824, 22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905667, 16621824, 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body accessory rod protein" /protein_id="NP_391521.1" /db_xref="EnsemblGenomes-Gn:BSU36400" /db_xref="EnsemblGenomes-Tr:CAB15657" /db_xref="GOA:P39752" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10917" /db_xref="UniProtKB/Swiss-Prot:P39752" /translation="MLKGLYTATSAMIAQQRRTEMLSNNIANANTSGYKADQGSMRAF PEMLLSRIESKSPAGTSRTEIGSVNTGVYMQELKPLFTQGSLKSTDQPTDIALIENQV PMSAETNEKAALFYPVQTADGIRYSKSSTFSLNENNQLTINGRPILSTDRQPITVDNE NFTVSENGTVTTNGRTAGQIDVRMAEDVRNLKRDGNDLYSTADGNDLPSAAGNNQVAY SLKQGVSELSNVDVTSAYTEMTEAYRSFEANQKVIQAYDKSMDKAANEIGKI*" /label="flhO CDS" gene complement(3140669..3141481) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /label="flhO gene" S_feature complement(3141482..3141561) /Source="Nicolas_S_feature" /locus_tag="new_3747092_3747171_c" /HighExp="C90, Lbtran, Cold, GM-0.2, GM 15, GM 10, C30, GM 90, GM-0.1, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.999, 0.837" /TUlongSig="NA" /TUlongPSig="NA" /label="S1404" promotor_-35 3141512..3141519 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3141533..3141552 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3141542 /Source="Nicolas_upshifts" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3141555..3141573) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-10" upshifts complement(3141561) /Source="Nicolas_upshifts" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="upshifts" promotor_-35 complement(3141587..3141594) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-35" CDS complement(3141644..3142645) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="MreB-like morphogen" /protein_id="NP_391522.2" /db_xref="EnsemblGenomes-Gn:BSU36410" /db_xref="EnsemblGenomes-Tr:CAB15658" /db_xref="GOA:P39751" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10916" /db_xref="UniProtKB/Swiss-Prot:P39751" /translation="MFARDIGIDLGTANVLIHVKGKGIVLNEPSVVALDKNSGKVLAV GEEARRMVGRTPGNIVAIRPLKDGVIADFEVTEAMLKHFINKLNVKGLFSKPRMLICC PTNITSVEQKAIKEAAEKSGGKHVYLEEEPKVAAIGAGMEIFQPSGNMVVDIGGGTTD IAVISMGDIVTSSSIKMAGDKFDMEILNYIKREYKLLIGERTAEDIKIKVATVFPDAR HEEISIRGRDMVSGLPRTITVNSKEVEEALRESVAVIVQAAKQVLERTPPELSADIID RGVIITGGGALLNGLDQLLAEELKVPVLVAENPMDCVAIGTGVMLDNMDKLPKRKLS* " /label="mbl CDS" gene complement(3141644..3142645) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /label="mbl gene" downshifts complement(3141650) /Source="Nicolas_upshifts" /id="D1884" /incds=0 /nref=108 /ntot=240 /MaxReadThrough="5.6154" /MaxDrop="4.18076" /score="20.122637" /energy="-11.2" /TU="U2854" /idTUdmin="U2855" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" misc_feature complement(3142700..3142719) /Source="Nicolas_upshift_promotors" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3142724) /Source="Nicolas_upshifts" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="upshifts" S_feature complement(3142726..3142810) /Source="Nicolas_S_feature" /locus_tag="new_3748336_3748420_c" /HighExp="S5, S6, S4, S7, S8, S3, B36, T5.0H, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1405" CDS complement(3142811..3143092) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023218, 9324264, 15598884, 22720735, 24584501" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023218, 9324264, 15598884, 22720735, 24584501; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (stage III sporulation)" /protein_id="NP_391523.1" /db_xref="EnsemblGenomes-Gn:BSU36420" /db_xref="EnsemblGenomes-Tr:CAB15659" /db_xref="GOA:P15281" /db_xref="InterPro:IPR014208" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="PDB:2L0K" /db_xref="SubtiList:BG10408" /db_xref="UniProtKB/Swiss-Prot:P15281" /translation="MHDYIKERTIKIGKYIVETKKTVRVIAKEFGVSKSTVHKDLTER LPEINPDLANEVKEILDYHKSIRHLRGGEATKLKYKKDEILEGEPVQQS*" /label="spoIIID CDS" gene complement(3142811..3143092) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /label="spoIIID gene" CDS complement(3143107..3143217) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9023218; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative factor required for translation of spoIIID" /protein_id="NP_391524.1" /db_xref="EnsemblGenomes-Gn:BSU36430" /db_xref="EnsemblGenomes-Tr:CAB15660" /db_xref="SubtiList:BG11984" /db_xref="UniProtKB/Swiss-Prot:O32276" /translation="MGIFHKLTFKTIQRRSGIMNDSLQNTDLISHFSHPF*" /label="usd CDS" gene complement(3143107..3143217) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /label="usd gene" promotor_-10 complement(3143248..3143266) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3143270) /Source="Nicolas_upshifts" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3143282..3143287) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3143363..3143369 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3143383..3143402 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3143399 /Source="Nicolas_upshifts" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="upshifts" CDS 3143442..3143855 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391525.1" /db_xref="EnsemblGenomes-Gn:BSU36440" /db_xref="EnsemblGenomes-Tr:CAB15661" /db_xref="GOA:P94578" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12495" /db_xref="UniProtKB/Swiss-Prot:P94578" /translation="MSYVNRHLIHQINQSARLIAKKANEQLEPFGLYSSQWSVLYCLR TIGPMTQKEIWSYLNVEAPTVTRTIKRLEENGWVQRRQGEDKREKLVVLTKEAEKKYE EINVKMLKFEEELLADFRDEDKEAFSHLFRMFLQQ*" /label="ywoH CDS" gene 3143442..3143855 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /label="ywoH gene" CDS 3143877..3145067 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391526.1" /db_xref="EnsemblGenomes-Gn:BSU36450" /db_xref="EnsemblGenomes-Tr:CAB15662" /db_xref="GOA:P94577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12494" /db_xref="UniProtKB/Swiss-Prot:P94577" /translation="MKKADAIWTKDFIMVLLVNLFVFVFFYTFLTVLPIYTLQELGGT ESQGGLLISLFLLSAIITRPFSGAIVERFGKKRMAIVSMALFALSSFLYMPIHNFSLL LGLRFFQGIWFSILTTVTGAIAADIIPAKRRGEGLGYFAMSMNLAMAIGPFLGLNLMR VVSFPVFFTAFALFMVAGLLVSFLIKVPQSKDSGTTVFRFAFSDMFEKGALKIATVGL FISFCYSTVTSYLSVFAKSVDLSDISGYFFVCFAVTMMIARPFTGKLFDKVGPGIVIY PSILIFSVGLCMLSFTHSGLMLLLSGAVIGLGYGSIVPCMQTLAIQKSPAHRSGFATA TFFTFFDSGIAVGSYVFGLFVASAGFSAIYLTAGLFVLIALLLYTWSQKKPAEAEGKV SIAE*" /label="ywoG CDS" gene 3143877..3145067 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /label="ywoG gene" CDS complement(3145158..3146564) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15266115, 16607952, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pectin lyase" /protein_id="NP_391527.1" /db_xref="EnsemblGenomes-Gn:BSU36460" /db_xref="EnsemblGenomes-Tr:CAB15663" /db_xref="GOA:P94576" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12493" /db_xref="UniProtKB/Swiss-Prot:P94576" /translation="MRKWYFILLAGVLTSVILAFVYDKTKANEEGSGDYLYVSPNGSD QNEGTKEKPFRTLAHASEKAAAGTTVMIREGTYHETLDVKHSGTDGKPITFRNYENEN VVISGESVANAEYETPLIRIHDKHDIAISGLTIQDLSVSSEEATAIGIYVSGSSSHIA IKDNHIRGIKTTADEGNAHGIAVYGTGSMKDIRIEDNTVEKLTLGASEAVVLNGNIDG FTVAGNVVRNNNNIGIDLIGYEGTADKNDYVRNGVVENNTVYQNSTYGNPAYGDEYSA GGIYVDGGHDIEIKNNTVYDNDIGIEATSEHKGKYANAIQITDNKVYNNAYTGISIGG YDKKRGGTSNSLIARNIMYRNDTKGLYGGQLLLQYDTKNNTIEKNILTAGDSRLFIGN DFTENEGNTVNHNVYHKEADQDGIWMWKKKEYDSFSSYRKATKNDQQSIYADPMFRDE ASYDFSLDPDSPARPVIE*" /label="ywoF CDS" gene complement(3145158..3146564) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /label="ywoF gene" downshifts complement(3145455) /Source="Nicolas_upshifts" /id="D1885" /incds=1 /nref=1 /ntot=78 /MaxReadThrough="5.28695" /MaxDrop="2.1962" /score="4.73902293" /energy="-22.3" /TU="U2857" /idTUdmin="U2857" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3146597..3146616) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3146615) /Source="Nicolas_upshifts" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3146631..3146634) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3146670..3148142) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 15849754, 16850406, 26967546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 15849754, 16850406, 26967546; Product type t : transporter" /codon_start=1 /transl_table=11 /product="allantoin permease" /protein_id="NP_391528.1" /db_xref="EnsemblGenomes-Gn:BSU36470" /db_xref="EnsemblGenomes-Tr:CAB15664" /db_xref="GOA:P94575" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR012681" /db_xref="SubtiList:BG12492" /db_xref="UniProtKB/Swiss-Prot:P94575" /translation="MKLKESQQQSNRLSNEDLVPLGQEKRTWKAMNFASIWMGCIHNI PTYATVGGLIAIGLSPWQVLAIIITASLILFGALALNGHAGTKYGLPFPVIIRASYGI YGANIPALLRAFTAIMWLGIQTFAGSTALNILLLNMWPGWGEIGGEWNILGIHLSGLL SFVFFWAIHLLVLHHGMESIKRFEVWAGPLVYLVFGGMVWWAVDIAGGLGPIYSQPGK FHTFSETFWPFAAGVTGIIGIWATLILNIPDFTRFAETQKEQIKGQFYGLPGTFALFA FASITVTSGSQVAFGEPIWDVVDILARFDNPYVIVLSVITLCIATISVNVAANIVSPA YDIANALPKYINFKRGSFITALLALFTVPWKLMESATSVYAFLGLIGGMLGPVAGVMM ADYFIIRKRELSVDDLYSETGRYVYWKGYNYRAFAATMLGALISLIGMYVPVLKSLYD ISWFVGVLISFLFYIVLMRVHPPASLAIETVEHAQVRQAE*" /label="pucI CDS" gene complement(3146670..3148142) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /label="pucI gene" CDS complement(3148323..3149681) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391529.1" /db_xref="EnsemblGenomes-Gn:BSU36480" /db_xref="EnsemblGenomes-Tr:CAB15665" /db_xref="GOA:P94574" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12491" /db_xref="UniProtKB/Swiss-Prot:P94574" /translation="MLSKKSRAVFLTAVASGTMLNPLNSSMISLALHSIQHEFHLSFT TVSWLISSFYLASAVAQPVTGKLGDLIGRKRLFLFGLILVAVSAIGAPFAPTFMTLLV MRLFQSVGSSAIYPSGVGLIRNHIHERQASALAVLSIFASAMTALGPTAGGFLIVWGG WPAIFIVNLPFIILSFLLGLYMFPKDQKKGAGIKTIIRQLDILGIVLFAGGIIFLLSF LLSFSTSPHAVEGVLGLLLLCAFVWRELKTDKPFIDVRLFKTQRNLSAVYVQFILLNV FFYCLFFGLPSYFQDEMHLSVQTSGLFMLFMSGMSIVVSPLTGKWIDRSGVVKPIFAG ALLMTAGAVLLTIFFINVQTIGKGLILSLLGIGYGLGNVALQAAMLETSPSNMVGTTS GLFQTCRYLGSILSSVILGILFGKEITAAHFDMMGIIMIIAGGASLLMAVRFAALMKT AS*" /label="ywoD CDS" gene complement(3148323..3149681) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /label="ywoD gene" downshifts complement(3148337) /Source="Nicolas_upshifts" /id="D1886" /incds=0 /nref=58 /ntot=198 /MaxReadThrough="1.44148" /MaxDrop="4.13092" /score="20.2036192" /energy="-12.8" /TU="NA" /idTUdmin="U2858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3149681..3150250) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of isochorismatase family" /protein_id="NP_391530.2" /db_xref="EnsemblGenomes-Gn:BSU36490" /db_xref="EnsemblGenomes-Tr:CAB15666" /db_xref="GOA:P94573" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12490" /db_xref="UniProtKB/Swiss-Prot:P94573" /translation="MMNTLNIDFQKTALVIIDLQKGIVPIDQSGQVVPNAKKLVDEFR KHNGFISFVNVAFHDGADALKPQTDEPAQGGSGEMPADWAEFVPEIGVQDGDYTVTKR QWGAFFGTDLDLQLRRRGIDTIVLCGIATNIGVESTAREAFQLGYQQIFITDAMSTFS DEEHEATLRFIFPRIGKSRTTEEFLEQVK*" /label="ywoC CDS" gene complement(3149681..3150250) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /label="ywoC gene" promotor_-10 complement(3150269..3150280) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3150287) /Source="Nicolas_upshifts" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3150294..3150300) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3150357..3150524) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CCQ48605.1" /translation="MSYPALDGPPQIHGHFQAGTDRQQAGDEAMTPFMITVLAGLFVC TTCYYYIKEKS*" /label="hypothetical protein CDS" gene complement(3150357..3150524) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /pseudo /label="gene" CDS complement(3150434..3150898) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21856850; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391531.1" /db_xref="EnsemblGenomes-Gn:BSU36500" /db_xref="EnsemblGenomes-Tr:CAB15667" /db_xref="GOA:P94572" /db_xref="InterPro:IPR020218" /db_xref="SubtiList:BG12489" /db_xref="UniProtKB/Swiss-Prot:P94572" /translation="MMNKGGRLRKAVRKSIPATFRLFLAFNFFVYGLAKVVIGQFGEV TPEIEAAAGKGFTIAWTFFGYSHVYELFIGFGEILAAVLLLIPRTAALGAVIFMPIIV NIVLINYCFDIGVQDLSTILMVMCLILLWMDRRKFMGIFRQEPIDSRQVMKR*" /label="ywoB CDS" gene complement(3150434..3150898) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /label="ywoB gene" promotor_-10 complement(3150928..3150947) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3150933) /Source="Nicolas_upshifts" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3150961..3150968) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3151099..3151102 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3151117..3151136 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3151121 /Source="Nicolas_upshifts" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3151180..3152394 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 15849754, 16850406, 17001076, 21435182" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 15849754, 16850406, 17001076, 21435182; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ammonium transporter" /protein_id="NP_391532.1" /db_xref="EnsemblGenomes-Gn:BSU36510" /db_xref="EnsemblGenomes-Tr:CAB15668" /db_xref="GOA:Q07429" /db_xref="InterPro:IPR001905" /db_xref="InterPro:IPR018047" /db_xref="InterPro:IPR024041" /db_xref="InterPro:IPR029020" /db_xref="SubtiList:BG10869" /db_xref="UniProtKB/Swiss-Prot:Q07429" /translation="MQMGDTVFMFFCALLVWLMTPGLALFYGGMVKSKNVLSTAMHSF SSIAIVSIVWVLFGYTLAFAPGNSIIGGLEWAGLKGVGFDPGDYSDTIPHSLFMMFQM TFAVLTTAIISGAFAERMRFGAFLLFSVLWASLVYTPVAHWVWGGGWIGQLGALDFAG GNVVHISSGVAGLVLAIVLGKRKDGTASSPHNLIYTFLGGALIWFGWFGFNVGSALTL DGVAMYAFINTNTAAAAGIAGWILVEWIINKKPTMLGAVSGAIAGLVAITPAAGFVTP FASIIIGIIGGAVCFWGVFSLKKKFGYDDALDAFGLHGIGGTWGGIATGLFATTSVNS AGADGLFYGDASLIWKQIVAIAATYVFVFIVTFVIIKIVSLFLPLRATEEEESLGLDL TMHGEKAYQDSM*" /label="amtB CDS" gene 3151180..3152394 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /label="amtB gene" promotor_-10 complement(3152010..3152028) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3152011) /Source="Nicolas_upshifts" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3152042..3152049) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3152260..3152266 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3152280..3152299 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3152282 /Source="Nicolas_upshifts" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3152406..3152756 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 17001076, 21435182, 23461034, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen-regulated PII-like regulator protein" /protein_id="NP_391533.1" /db_xref="EnsemblGenomes-Gn:BSU36520" /db_xref="EnsemblGenomes-Tr:CAB15669" /db_xref="GOA:Q07428" /db_xref="InterPro:IPR002187" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017918" /db_xref="PDB:4R25" /db_xref="PDB:4RX6" /db_xref="SubtiList:BG10870" /db_xref="UniProtKB/Swiss-Prot:Q07428" /translation="MSGQMFKVEIVTRPANFEKLKQELGKIGVTSLTFSNVHGCGLQK AHTELYRGVKIESNVYERLKIEIVVSKVPVDQVTETAKRVLKTGSPGDGKIFVYEISN TINIRTGEEGPEAL*" /label="glnK CDS" gene 3152406..3152756 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /label="glnK gene" downshifts 3152749 /Source="Nicolas_upshifts" /id="D1887" /incds=0 /nref=179 /ntot=251 /MaxReadThrough="2.13701" /MaxDrop="8.63831" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2860" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3152808..3152816 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3152830..3152838 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3152837 /Source="Nicolas_upshifts" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3152879..3152888 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3152901..3152916 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3152905 /Source="Nicolas_upshifts" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" CDS 3152937..3153518 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /EC_number="3.6.1.27" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate phosphatase (bacitracin resistance)" /protein_id="NP_391534.1" /db_xref="EnsemblGenomes-Gn:BSU36530" /db_xref="EnsemblGenomes-Tr:CAB15670" /db_xref="GOA:P94571" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR033879" /db_xref="InterPro:IPR036938" /db_xref="SubtiList:BG12488" /db_xref="UniProtKB/Swiss-Prot:P94571" /translation="MNYEIFKAIHGLSHHNSVLDSIMVFITEYAIVAYALILLAIWLF GNTQSRKHVLYAGITGIAGLVINYLITLVYFEPRPFVAHTVHTLIPHAADASFPSDHT TGALAISIAMLFRNRKIGWPLVIFGLLTGFSRIWVGHHYPVDVLGSLVVAIIIGFLFF RFSDLLRPFVDLVVRIYEAIINKLTKKPTDQNF*" /label="bcrC CDS" gene 3152937..3153518 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /label="bcrC gene" promotor_-10 complement(3153035..3153054) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3153045) /Source="Nicolas_upshifts" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3153068..3153076) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3153499 /Source="Nicolas_upshifts" /id="D1888" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.1929" /MaxDrop="6.53316" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2863" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(3153559..3153981) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14762009, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391535.1" /db_xref="EnsemblGenomes-Gn:BSU36540" /db_xref="EnsemblGenomes-Tr:CAB15671" /db_xref="GOA:P71045" /db_xref="InterPro:IPR006976" /db_xref="SubtiList:BG12487" /db_xref="UniProtKB/Swiss-Prot:P71045" /translation="MNRLLLAGWIFFILLSVCTESFSGMVVSQTVAFHFQPHPDLSQF LVMDFTELTVPEAFIQKIGHAFSFFVLTYLLWKQRGSIRSAAAGSFAFAFFTEVLQLF FSRNGCIRDVLIDAVGIGLFYGLYVLAKRRKQEMYEKY*" /label="ywnJ CDS" gene complement(3153559..3153981) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /label="ywnJ gene" downshifts complement(3153578) /Source="Nicolas_upshifts" /id="D1889" /incds=0 /nref=9 /ntot=75 /MaxReadThrough="0.80227" /MaxDrop="3.65224" /score="4.98901321" /energy="-13.6" /TU="NA" /idTUdmin="U2869" /TUdmin=215 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3154016..3154031) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3154035) /Source="Nicolas_upshifts" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3154044..3154053) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3154092..3154943) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /function="16.8: Protect" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore protein required for alternative engulfment" /protein_id="NP_391536.1" /db_xref="EnsemblGenomes-Gn:BSU36550" /db_xref="EnsemblGenomes-Tr:CAB15672" /db_xref="GOA:P71044" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11978" /db_xref="UniProtKB/Swiss-Prot:P71044" /translation="MREEEKKTSQVKKLQQFFRKRWVFPAIYLVSAAVILTAVLWYQS VSNDEVKDQLADNGGNSAYDNNDDAVEVGKSMENVAMPVVDSENVSVVKKFYETDAAK EEKEAALVTYNNTYSLSKGIDLAEKDGKDFDVSASLSGTVVKAEKDPVLGYVVEVEHA DGLSTVYQSLSEVSVEQGDKVKQNQVIGKSGKNLYSEDSGNHVHFEIRKDGVAMNPLN FMDKPVSSIEKAATQETEESIQQSSEKKDGSTEKGTEEKSGEKKDDSTDKSGSKESST TEDTEQS*" /label="spoIIQ CDS" gene complement(3154092..3154943) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /label="spoIIQ gene" downshifts complement(3154101) /Source="Nicolas_upshifts" /id="D1890" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.592" /MaxDrop="5.16472" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts complement(3154343) /Source="Nicolas_upshifts" /id="D1891" /incds=1 /nref=4 /ntot=59 /MaxReadThrough="6.6416" /MaxDrop="3.0034" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" promotor_-35 3154580..3154582 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3154599..3154618 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3154600..3154946 /Source="Nicolas_S_feature" /locus_tag="new_3760210_3760556" /HighExp="LBGstat, LBGtran, Cold, Sw, dia15, C30, G180, Lbexp, LBGexp, UNK1" /AntisenseName="spoIIQ" /AntisenseCor="-0.81767802234568998" /AntisenseRegPval="-65.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1406" upshifts 3154600 /Source="Nicolas_upshifts" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3154938..3154941 /Source="Nicolas_upshift_promotors" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3154948..3155083 /Source="Nicolas_S_feature" /locus_tag="new_3760558_3760693" /HighExp="LBGstat, S8, LBGtran, Sw, LoTm, BC, Cold, S7, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.122, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1407" upshifts 3154948 /Source="Nicolas_upshifts" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3154977) /Source="Nicolas_upshifts" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3154983..3154992) /Source="Nicolas_upshift_promotors" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3155084..3155575 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /EC_number="2.3.1.183" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 16021622, 27694229; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacid analogs (phosphinothricin) N-acetyltransferase" /protein_id="NP_391537.1" /db_xref="EnsemblGenomes-Gn:BSU36560" /db_xref="EnsemblGenomes-Tr:CAB15673" /db_xref="GOA:P71043" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1VHS" /db_xref="SubtiList:BG12486" /db_xref="UniProtKB/Swiss-Prot:P71043" /translation="MTLRLAEHRDLEAVVAIYNSTIASRMVTADTEPVTPEDRMEWFS GHTESRPLYVAEDENGNVAAWISFETFYGRPAYNKTAEVSIYIDEACRGKGVGSYLLQ EALRIAPNLGIRSLMAFIFGHNKPSLKLFEKHGFAEWGLFPGIAEMDGKRYDLKILGR ELS*" /label="ywnH CDS" gene 3155084..3155575 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /label="ywnH gene" promotor_-35 3155313..3155318 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3155334..3155352 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3155345 /Source="Nicolas_upshifts" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3155436..3156344) /Source="Nicolas_S_feature" /locus_tag="new_3761046_3761954_c" /HighExp="H2O2, dia15, Diami, dia5, S8, Paraq, G180, G135, C30, G150" /AntisenseName="ywnG" /AntisenseCor="0.27407310266030799" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S1408" CDS 3155572..3156090 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391538.1" /db_xref="EnsemblGenomes-Gn:BSU36570" /db_xref="EnsemblGenomes-Tr:CAB15674" /db_xref="GOA:P71042" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12485" /db_xref="UniProtKB/Swiss-Prot:P71042" /translation="MISLDKDENEIEHHNEENSLVEQETAPVGQESRQLSASAVKSLS DIAKWGKISGILLIIMGSLVTLSVLMTVIGAIPGVLLIISGVFLMRSAKAAAEAEGNL TGSAGESMLENYGTFIKMQLFYAASSIVTVLIGIIVAIFVLVVIGIAAFENTPSYDDP DSYYYEDDPVFE*" /label="ywnG CDS" gene 3155572..3156090 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /label="ywnG gene" downshifts 3155895 /Source="Nicolas_upshifts" /id="D1892" /incds=1 /nref=1 /ntot=29 /MaxReadThrough="4.194" /MaxDrop="1.82458" /score="-3.39058903" /energy="-13.3" /TU="U2867,U2868,U2870" /idTUdmin="U2868" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 3156093 /Source="Nicolas_upshifts" /id="D1893" /incds=0 /nref=3 /ntot=133 /MaxReadThrough="2.87136" /MaxDrop="2.9486" /score="-3.39058903" /energy="-13.3" /TU="U2867" /idTUdmin="U2870" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3156249..3156380 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514007.1" /translation="MNIKKTDEVGINPKPHFLFRVSACKKTHPDRLENLNNPGADLL* " /label="hypothetical protein CDS" gene 3156249..3156380 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /label="gene" CDS complement(3156377..3156811) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391539.1" /db_xref="EnsemblGenomes-Gn:BSU36580" /db_xref="EnsemblGenomes-Tr:CAB15675" /db_xref="GOA:P71041" /db_xref="InterPro:IPR020205" /db_xref="SubtiList:BG12484" /db_xref="UniProtKB/Swiss-Prot:P71041" /translation="MNFYRVEQMPGFIKTEMQKIQKAVQPFMKKTVIYRFLAIPLAAF SLFNLAAFLFHASADRESLISAGIFALLAALGLAFFKEAGYQHKQIQKTVHIYMLNRI KKSEILSEERKSSYARQIKEEPFAMRSFVEFLTEEDRRKKMY*" /label="ywnF CDS" gene complement(3156377..3156811) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /label="ywnF gene" downshifts complement(3156389) /Source="Nicolas_upshifts" /id="D1894" /incds=0 /nref=174 /ntot=254 /MaxReadThrough="4.22489" /MaxDrop="5.35802" /score="21.5198482" /energy="-21.3" /TU="U2871" /idTUdmin="U2873" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3156860..3156879) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3156867) /Source="Nicolas_upshifts" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3156869..3157166) /Source="Nicolas_S_feature" /locus_tag="new_3762479_3762776_c" /HighExp="Etha, S6, S3, S4, S8, S5, S7, M9-stat, Sw, Salt" /AntisenseName="clsA" /AntisenseCor="-0.16109419145114601" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF" /TUshortPSig="0.99, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1409" promotor_-35 complement(3156894..3156901) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3156940..3156944 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3156961..3156980 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3156973..3157053 /Source="Nicolas_S_feature" /locus_tag="new_3762583_3762663" /HighExp="LBGstat, Diami, dia15, G180, Oxctl, H2O2, T0.30H, S8, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1410" upshifts 3156974 /Source="Nicolas_upshifts" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3157054..3158502 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14973018, 16755131, 18820022, 26708983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16755131, 18820022, 26708983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cardiolipin synthase (major)" /protein_id="NP_391540.1" /db_xref="EnsemblGenomes-Gn:BSU36590" /db_xref="EnsemblGenomes-Tr:CAB15676" /db_xref="GOA:P71040" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG12483" /db_xref="UniProtKB/Swiss-Prot:P71040" /translation="MSISSILLSLFFILNILLAIIVIFKERRDASASWAWLLVLFFIP VLGFILYLLFGHNLRRKHLFQWEDRKKIGIERLLKHQLEDLETKQFQFNNRATFDNKD LIYMLIMNNHAVFTEDNSVDVITDGRDKFQRLLSDISKAKDHIHLQYYIYKGDELGKK LRDALIQKAKEGVQVRVLYDELGSRTLRKKFFKELREAGGHVEVFFPSKLRPINLRLN YRNHRKLVIIDGMTGYVGGFNVGDEYLGLNPKFGYWRDTHIRLQGTAVHAIQTRFILD WNQASHHHTLTYIPNHFPDYGPKGNVGMQIVTSGPDSEWEQIKNGYIKMISNAKRSIL IQTPYFIPDASLLDALRIACLSGIDVNIMIPNKPDHAFVYWATLSYIGDLLKAGATVY IYDNGFIHAKTIVVDDEIASVGTANIDVRSFRLNFEVNAFIYDITIAKKLVSTFKEDL LVSRKFTYEEYLQRPLWIRIKESVSRLLSPIL*" /label="clsA CDS" gene 3157054..3158502 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /label="clsA gene" upshifts complement(3157166) /Source="Nicolas_upshifts" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3157167..3157185) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3157168..3157511) /Source="Nicolas_S_feature" /locus_tag="new_3762778_3763121_c" /HighExp="S6, S8, S4, S5, S7, S3, T5.0H, M9-stat, C30, T4.0H" /AntisenseName="clsA" /AntisenseCor="3.3648966966722899E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1411" promotor_-35 complement(3157201..3157207) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3157489..3157507) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3157511) /Source="Nicolas_upshifts" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3157523..3157528) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3158491 /Source="Nicolas_upshifts" /id="D1895" /incds=0 /nref=6 /ntot=214 /MaxReadThrough="0.7051" /MaxDrop="4.44298" /score="26.7449315" /energy="-19.5" /TU="NA" /idTUdmin="U2872" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3158523..3159296) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10200972, 11581256, 18502870" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 11581256, 18502870; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulating efflux transporters synthesis (Fur-independent bacillibactin export)" /protein_id="NP_391541.1" /db_xref="EnsemblGenomes-Gn:BSU36600" /db_xref="EnsemblGenomes-Tr:CAB15677" /db_xref="GOA:P71039" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012925" /db_xref="InterPro:IPR036244" /db_xref="PDB:1JBG" /db_xref="PDB:1R8D" /db_xref="SubtiList:BG12482" /db_xref="UniProtKB/Swiss-Prot:P71039" /translation="MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDA DLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAALQSQKEILMKKKQRMDEMIQTID RTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSA DDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGE VYITDERFTDSINQYGEGLAAFLREAIIIYCDHQENPRP*" /label="mta CDS" gene complement(3158523..3159296) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /label="mta gene" downshifts complement(3158545) /Source="Nicolas_upshifts" /id="D1896" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="0.46006" /MaxDrop="2.97389" /score="11.4339746" /energy="-19.5" /TU="NA" /idTUdmin="U2876" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" promotor_-35 3159371..3159374 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3159390..3159409 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3159394 /Source="Nicolas_upshifts" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="upshifts" CDS 3159441..3159824 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391542.1" /db_xref="EnsemblGenomes-Gn:BSU36610" /db_xref="EnsemblGenomes-Tr:CAB15678" /db_xref="GOA:P71038" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12481" /db_xref="UniProtKB/Swiss-Prot:P71038" /translation="MNPETMNKTLISISKWGKATGILFIIMGAITALSGAFFFLIGAV PGVLQIISGIFLMRSAREAGQMAEHNSGQSEDLMLENYAKFVKMQGIYLIVSIAVSIL AIIAFFIFLMLGIADGLFSDTYSTY*" /label="ywnC CDS" gene 3159441..3159824 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /label="ywnC gene" downshifts 3159811 /Source="Nicolas_upshifts" /id="D1897" /incds=0 /nref=60 /ntot=180 /MaxReadThrough="1.0319" /MaxDrop="4.45212" /score="35.5991488" /energy="-11.4" /TU="NA" /idTUdmin="U2875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3159859..3160500) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391543.1" /db_xref="EnsemblGenomes-Gn:BSU36620" /db_xref="EnsemblGenomes-Tr:CAB15679" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12480" /db_xref="UniProtKB/Swiss-Prot:P71037" /translation="MKIGIIGASGKAGNEILKEAKKRGHEVTAIVRNASKVQEQDVAI LEKDVFELTAEDIKPFDAVVNAFGAAPGQEHLHVEAGRALISILKDAKHTRLLVVGGA GSLFVDEAKTTRLMDTPEFPKEYLPTASNQGENLKDLQQTDSISWTFLSPAAFFDPAG KRTGSYQKGKDNVIVNAKGDSYISYADYAIAVLDELEHPEHKNERFTVVSEAE*" /label="ywnB CDS" gene complement(3159859..3160500) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /label="ywnB gene" downshifts complement(3159909) /Source="Nicolas_upshifts" /id="D1898" /incds=0 /nref=20 /ntot=170 /MaxReadThrough="3.62026" /MaxDrop="4.98934" /score="21.1363072" /energy="-11.4" /TU="U2876" /idTUdmin="U2876" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(3160568..3160969) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391544.1" /db_xref="EnsemblGenomes-Gn:BSU36630" /db_xref="EnsemblGenomes-Tr:CAB15680" /db_xref="GOA:P71036" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1XD7" /db_xref="SubtiList:BG12479" /db_xref="UniProtKB/Swiss-Prot:P71036" /translation="MINSRLAVAIHILSLISMDEKTSSEIIADSVNTNPVVVRRMISL LKKADILTSRAGVPGASLKKDPADISLLEVYRAVQKQEELFAVHENPNPKCPVGKKIQ NALDETFESVQRAMENELASKSLKDVMNHLF*" /label="ywnA CDS" gene complement(3160568..3160969) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /label="ywnA gene" promotor_-10 complement(3161018..3161037) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3161028) /Source="Nicolas_upshifts" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3161030..3161103) /Source="Nicolas_S_feature" /locus_tag="new_3766640_3766713_c" /HighExp="BT, Etha, S1, B60, LoTm, B36, S2, Glucon, Sw, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.18507799999999999" /TUshortSig="Sig-" /TUshortPSig="0.106" /TUlongSig="SigH, SigA, SigB, SigB" /TUlongPSig="1, 0.993, 1, 0.995" /label="S1412" promotor_-35 complement(3161052..3161057) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3161104..3162813) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (alpha subunit)" /protein_id="NP_391545.1" /db_xref="EnsemblGenomes-Gn:BSU36640" /db_xref="EnsemblGenomes-Tr:CAB15681" /db_xref="GOA:P77837" /db_xref="InterPro:IPR005848" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR011612" /db_xref="InterPro:IPR017950" /db_xref="InterPro:IPR017951" /db_xref="InterPro:IPR029754" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11983" /db_xref="UniProtKB/Swiss-Prot:P77837" /translation="MKMSREEYAELFGPTTGDKIRLGDTDLWIEVEKDFTVYGEEMIF GGGKTIRDGMGQNGRITGKDGALDLVITNVVLLDYTGIVKADVGVKDGRIVGVGKSGN PDIMDGVDPHMVIGAGTEVISGEGKILTAGGVDTHIHFICPQQMEVALSSGVTTLLGG GTGPATGSKATTCTSGAWYMARMLEAAEEFPINVGFLGKGNASDKAPLIEQVEAGAIG LKLHEDWGTTPSAIKTCMEVVDEADIQVAIHTDTINEAGFLENTLDAIGDRVIHTYHI EGAGGGHAPDIMKLASYANILPSSTTPTIPYTVNTMDEHLDMMMVCHHLDAKVPEDVA FSHSRIRAATIAAEDILHDIGAISMTSSDSQAMGRVGEVIIRTWQVADKMKKQRGALA GENGNDNVRAKRYIAKYTINPAITHGLSHEVGSVEKGKLADLVLWDPVFFGVKPELVL KGGMIARAQMGDPNASIPTPEPVFMRQMYASYGKANRSTSITFMSQASIERGVAESLG LEKRISPVKNIRKLSKLDMKLNSALPKIEIDPKTYQVFADGEELSCQPVDYVPLGQRY FLF*" /label="ureC CDS" gene complement(3161104..3162813) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /label="ureC gene" CDS complement(3162810..3163184) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (beta subunit)" /protein_id="NP_391546.1" /db_xref="EnsemblGenomes-Gn:BSU36650" /db_xref="EnsemblGenomes-Tr:CAB15682" /db_xref="GOA:P71035" /db_xref="InterPro:IPR002019" /db_xref="InterPro:IPR036461" /db_xref="SubtiList:BG11982" /db_xref="UniProtKB/Swiss-Prot:P71035" /translation="MKPGAFQIAEGTITINEGREIREVTVKNTGSRSIQVGSHFHFAE ANGALLFDRELAIGMRLDVPSGTSVRFEPGEQKTVSLVEIRGRKTIRGLNGMADTFID ERGKEKTLANLKQAGWMEGVIR*" /label="ureB CDS" gene complement(3162810..3163184) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /label="ureB gene" CDS complement(3163181..3163498) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /EC_number="3.5.1.5" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (gamma subunit)" /protein_id="NP_391547.1" /db_xref="EnsemblGenomes-Gn:BSU36660" /db_xref="EnsemblGenomes-Tr:CAB15683" /db_xref="GOA:P75030" /db_xref="InterPro:IPR002026" /db_xref="InterPro:IPR012010" /db_xref="InterPro:IPR036463" /db_xref="SubtiList:BG11981" /db_xref="UniProtKB/Swiss-Prot:P75030" /translation="MKLTPVEQEKLLIFAAGELAKQRKARGVLLNYPEAAAYITCFIM EGARDGKGVAELMEAGRHVLTEKDVMEGVPEMLDSIQVEATFPDGVKLVTVHQPISAE VKS*" /label="ureA CDS" gene complement(3163181..3163498) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /label="ureA gene" S_feature complement(3163499..3163583) /Source="Nicolas_S_feature" /locus_tag="new_3769109_3769193_c" /HighExp="BT, B60, B36, S1, Etha, LoTm, M9-stat, S2, T0.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigH, SigB" /TUshortPSig="0.106, 1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1413" upshifts complement(3163583) /Source="Nicolas_upshifts" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3163585..3163598) /Source="Nicolas_upshift_promotors" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(3163585..3163678) /Source="Nicolas_S_feature" /locus_tag="new_3769195_3769288_c" /HighExp="BT, Etha, B60, S1, B36, BC, S2, LoTm, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30781199999999997" /TUshortSig="SigH, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1414" CDS complement(3163679..3163843) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (putative phage interference protein)" /protein_id="YP_009514008.1" /translation="MVNLKNILLNKQLEGIQILIVELVRQVIIEISRKKDICYLSRAQ SGKRVNLIFP*" /label="ywzE CDS" gene complement(3163679..3163843) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /label="ywzE gene" promotor_-10 complement(3163766..3163784) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-10" upshifts complement(3163778) /Source="Nicolas_upshifts" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="upshifts" promotor_-35 complement(3163796..3163804) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-35" S_feature complement(3163844..3164015) /Source="Nicolas_S_feature" /locus_tag="new_3769454_3769625_c" /HighExp="Etha, BT, S1, GM-0.2, GM-0.1, Salt, GM 5, T-5.40H, MG 60, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1415" CDS complement(3164016..3164198) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="PSEUDO:CAX52705.1" /translation="MKAGILHSLRGTVAISEVTVHDAELMAIVGFSVSWRSAPQTGLH AMLPVAEQNNGLPSGM*" /label="ywzF CDS" gene complement(3164016..3164198) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /pseudo /label="ywzF gene" S_feature complement(3164199..3164345) /Source="Nicolas_S_feature" /locus_tag="new_3769809_3769955_c" /HighExp="Etha, BT, S1, Salt, GM-0.2, GM-0.1, M9-stat, GM 5, GM 45, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15897800000000001" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1416" promotor_-10 complement(3164333..3164352) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3164345) /Source="Nicolas_upshifts" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" S_feature complement(3164347..3164461) /Source="Nicolas_S_feature" /locus_tag="new_3769957_3770070_c" /HighExp="Etha, Salt, M9-stat, S8, B60, B36, Sw, Gly, LoTm, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1417" promotor_-35 complement(3164367..3164374) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" Polymorphism join(3164448,3164450) /Source="geneious" /ID="SNP_BsDelta6_3770059_3770058" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)8 -> (A)9" /Codon_Change /Coverage=64 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="2.1e-197" /Variant_Raw_Frequency=61 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 3164475 /Source="Nicolas_upshifts" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3164478..3164482 /Source="Nicolas_upshift_promotors" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3164495..3164683) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10376822, 11988534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376822, 11988534; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein" /protein_id="NP_391548.1" /db_xref="EnsemblGenomes-Gn:BSU36670" /db_xref="EnsemblGenomes-Tr:CAB15684" /db_xref="InterPro:IPR008462" /db_xref="InterPro:IPR036629" /db_xref="SubtiList:BG12478" /db_xref="UniProtKB/Swiss-Prot:P70964" /translation="MGNDSVKDKMKGGFNKAKGEVKDKVGDMADRTDMQAEGKKDKAK GEIQKDIGKAKDKFSDKD*" /label="csbD CDS" gene complement(3164495..3164683) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /label="csbD gene" downshifts complement(3164506) /Source="Nicolas_upshifts" /id="D1899" /incds=0 /nref=69 /ntot=139 /MaxReadThrough="6.39376" /MaxDrop="6.75256" /score="21.8463823" /energy="-10.2" /TU="U2881" /idTUdmin="U2882" /TUdmin=221 /isTUend="FALSE" /label="downshifts" downshifts 3164673 /Source="Nicolas_upshifts" /id="D1900" /incds=0 /nref=15 /ntot=36 /MaxReadThrough="0.59322" /MaxDrop="5.27268" /score="-5.47050177" /energy="-8.1" /TU="NA" /idTUdmin="U2880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3164709..3164727) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3164720) /Source="Nicolas_upshifts" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3164741..3164747) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3164756..3165256) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391549.2" /db_xref="EnsemblGenomes-Gn:BSU36680" /db_xref="EnsemblGenomes-Tr:CAB15685" /db_xref="GOA:P70963" /db_xref="SubtiList:BG12477" /db_xref="UniProtKB/Swiss-Prot:P70963" /translation="MHVRGNSMFGFNDMVKFLWSFLIVLPLVQIIHVSGHSFMAFIFG GKGSLDIGMGKTLLKIGPIRFRTIYFIDSFCRYGELKIDNRFSNALVYAGGCLFNLIT IFAINLLIIHSVLKPNVFFYQFVYFSTYYVFFALLPVRYSEKKSSDGLAIYKVLRYGE RYEIDK*" /label="ywmF CDS" gene complement(3164756..3165256) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /label="ywmF gene" promotor_-10 complement(3165292..3165311) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3165299) /Source="Nicolas_upshifts" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3165325..3165331) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3165391..3166524) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9843420, 10629174, 12875849, 19332814, 19684115" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9843420, 10629174, 12875849, 19332814, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391550.1" /db_xref="EnsemblGenomes-Gn:BSU36690" /db_xref="EnsemblGenomes-Tr:CAB15686" /db_xref="GOA:P70962" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11965" /db_xref="UniProtKB/Swiss-Prot:P70962" /translation="MAAYEIPSSQVGVKINKWYKHILAFQVADAVKLKEEIDLDIEQM EEDQLLLLYYQLISYRHQIMLDYVKPDLHEESQLQYRELIKTLESNQDSISGLSEYYF HLFRGMYEFEQNNYISAISFYRKAEKMLAFVEDEIERAEFHFKVAEVFYIMKQTHFSM NHAVQALETYKAHDFYRVRRIQCHFVISGNYIDYRNYEKALEHLDDAYRLALLEGQPR LIGSALYNIGNCYDDKGELDQAAEYFEKALPVFEDYQLEQLPKALFSLTRVLFKKQDS EAAIRYYEKGIAIAQKRNDFFSLAKYKFLQALYVESVNLNMIQEVFDYMEEKGLYVYI EEFALDAASYFSHREQYKEAVYFYEKAVSMREMIQRNDCLYEV*" /label="rapB CDS" gene complement(3165391..3166524) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /label="rapB gene" downshifts complement(3165409) /Source="Nicolas_upshifts" /id="D1901" /incds=0 /nref=244 /ntot=265 /MaxReadThrough="2.8683" /MaxDrop="6.81344" /score="30.5146793" /energy="-8.1" /TU="NA" /idTUdmin="U2883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(3166551..3166570) /Source="Nicolas_upshift_promotors" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3166558) /Source="Nicolas_upshifts" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3166621..3166639) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3166637) /Source="Nicolas_upshifts" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3166653..3166660) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3166716..3167741) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /EC_number="4.1.99.22" /function="16.10: Respire" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170340, 7860592, 16632608, 19566093, 23286307, 25896388, 25941396, 26575208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP 3',8-cyclase" /protein_id="NP_391551.1" /db_xref="EnsemblGenomes-Gn:BSU36700" /db_xref="EnsemblGenomes-Tr:CAB15687" /db_xref="GOA:P39757" /db_xref="InterPro:IPR000385" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010505" /db_xref="InterPro:IPR013483" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG10980" /db_xref="UniProtKB/Swiss-Prot:P39757" /translation="MITESRQMLDKRNRPLRDLRISVTDRCNFRCTYCMPAELFGPDY PFLKKEELLSFEELERLATLFVTRFGVEKIRLTGGEPLMRKDMPELIKKLARIPGIRD IAMTTNGSLLPVYAKRLKEAGLKRVTISLDSLEDERFKKINGRGVSVSKVLEGIEAAK QAGLGVKINMVVQKGVNEKDILPMARYFKEKGHILRFIEFMDVGNTNQWEKKDVMTKA EIIDLINKHMPVEPIAPNYIGEVASRFRYLDGSGEIGVISSVSDAFCGSCNRARLSAR GELFTCLFASSGFDLRAPVRQELSDDELSEMIGTVWKNRIDQYSVDRTLSKASGKKKV EMSYIGG*" /label="moaA CDS" gene complement(3166716..3167741) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /label="moaA gene" downshifts complement(3166729) /Source="Nicolas_upshifts" /id="D1902" /incds=0 /nref=23 /ntot=147 /MaxReadThrough="3.05546" /MaxDrop="3.66108" /score="13.625744" /energy="-10.8" /TU="NA" /idTUdmin="U2885" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3167757..3168545) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /function="16.11: Scavenge (Catabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2170340, 7860592, 19114526, 20011599, 22194618; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein sulfur transferase involved in molybdenum cofactor synthesis" /protein_id="NP_391552.1" /db_xref="EnsemblGenomes-Gn:BSU36710" /db_xref="EnsemblGenomes-Tr:CAB15688" /db_xref="GOA:P39756" /db_xref="InterPro:IPR003786" /db_xref="InterPro:IPR016193" /db_xref="SubtiList:BG10979" /db_xref="UniProtKB/Swiss-Prot:P39756" /translation="MNDKVTAVRDVWRYEQGEISKVEDRMVTEFPLTVILNGSEFVTL VCTPEHIEELVIGFLASEGVIRFQKEIKRFTIDESLGFVYVDLVHPETLDQKDYTKRV IGSCCGKGRHFYFQQDVKTAKTAVSQIKISPEACLALMKDMQQGSGTFQDTGGVHNAA LCDTEKLLLMRTDIGRHNALDKLYGHCLLNGMSVRDKLIVFSGRISSEVLLKAAKIGV SIVISKSAPTELAIQMAEELNITAIGFVRNGSFNVYTHPERIRE*" /label="fdhD CDS" gene complement(3167757..3168545) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /label="fdhD gene" promotor_-10 complement(3168571..3168590) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3168577) /Source="Nicolas_upshifts" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3168579..3168790) /Source="Nicolas_S_feature" /locus_tag="new_3774188_3774399_c" /HighExp="Etha, Sw, Salt, Heat, S8, Gly, S6, S7, BC, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16930300000000001" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1418" promotor_-35 complement(3168604..3168611) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3168791..3168952) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391553.1" /db_xref="EnsemblGenomes-Gn:BSU36720" /db_xref="EnsemblGenomes-Tr:CAB15689" /db_xref="GOA:P70966" /db_xref="SubtiList:BG12476" /db_xref="UniProtKB/Swiss-Prot:P70966" /translation="MKLFGMIFLIATVAFILLGVLLKLAAFFFVSILTLIAAIVLFTV LKKNQHNQT*" /label="ywmE CDS" gene complement(3168791..3168952) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /label="ywmE gene" promotor_-10 complement(3168965..3168983) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-10" upshifts complement(3168985) /Source="Nicolas_upshifts" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="upshifts" promotor_-35 complement(3168997..3169003) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-35" CDS complement(3169046..3169720) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391554.1" /db_xref="EnsemblGenomes-Gn:BSU36730" /db_xref="EnsemblGenomes-Tr:CAB15690" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12475" /db_xref="UniProtKB/Swiss-Prot:P70961" /translation="MKKLLAAGIIGLLTVSIASPSFAAEKQADTNVAVLFDGSGSMVQ KTGGERKIDIAKKSVKSFAELLPKDTNLMLRVFGHAGNNKLSGKALSCSTTETIYGLH PYEGSLFDNSLSELKPTGWTPIAKALADTRKEFEAFDADGKNVVYLITDGEETCGGDP AAEIEKLRASNVDTIVNIIGFNFDVKGNEEMKQAAVAGGGEYISANSADEFEQAWEKE AQKFTE*" /label="ywmD CDS" gene complement(3169046..3169720) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /label="ywmD gene" downshifts complement(3169061) /Source="Nicolas_upshifts" /id="D1903" /incds=0 /nref=16 /ntot=88 /MaxReadThrough="0.76221" /MaxDrop="4.19611" /score="25.2461653" /energy="-9.6" /TU="NA" /idTUdmin="U2886" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(3169773..3169913) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514009.1" /translation="MITQAVYAFWAEMAKNERHFKRFWTDRESSTKGSMSYIFLHFRI LA*" /label="hypothetical protein CDS" gene complement(3169773..3169913) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /label="gene" CDS complement(3170044..3170727) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391555.1" /db_xref="EnsemblGenomes-Gn:BSU36740" /db_xref="EnsemblGenomes-Tr:CAB15691" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12474" /db_xref="UniProtKB/Swiss-Prot:P70960" /translation="MKKRFSLIMMTGLLFGLTSPAFAAEKTETEAKAPANVAVLLDAS GSMAKRIDGVSKFNSAKKEISKFASSLPEGTQVKMSVFGSEGNNKNSGKVQSCEAIRN VYGFQSFNEQSFLNSLNTIGPTGWTPIAKALNEAKSSFDQLDAKGEKVVYLLTDGEET CGGNPIKTAKELQKDNITVNVIGFDYKEGYKGQLNAIAKVGGGEYFPAYTQKDVEKIF TQQSLMLSK*" /label="ywmC CDS" gene complement(3170044..3170727) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /label="ywmC gene" promotor_-35 3171104..3171108 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3171113..3172144) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15752199, 16959571, 17376078, 27226615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15752199, 16959571, 17376078, 27226615; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="lytic transglycosylase; autolysin required for complete dissolution of the asymmetric septum (stage II sporulation)" /protein_id="NP_391556.1" /db_xref="EnsemblGenomes-Gn:BSU36750" /db_xref="EnsemblGenomes-Tr:CAB15692" /db_xref="GOA:P07372" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="InterPro:IPR014225" /db_xref="SubtiList:BG10766" /db_xref="UniProtKB/Swiss-Prot:P07372" /translation="MKQFAITLSVLCALILLVPTLLVIPFQHNKEAGASVESEKTAVS TKPASKGAETLKASPVSIPVYRTANQSVENIPLEEYVIGVVASEMPATFKPEALKAQA LAARTFIVRLMVSNSAVEAPKGSLVDDTQMFQVYKSKAELKKQWGTSYETKLKKITDA VASTQGKILTYNNQPIEASFFSTSNGYTENAEAYWTSAIPYLKSVKSPWDKKSPKYKA TKTFTAAEFQQKLGVKLDGSSAVGKITGETPGHQVATAVINGKTLKGRDIREKLGLNS ADFEWKRNGDTITVTTRGFGHGVGMSQYGANFMAKEGKTVDDIVKYYYQGTQISEADA FLNKYMAKK*" /label="spoIID CDS" gene complement(3171113..3172144) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /label="spoIID gene" promotor_-10 3171123..3171142 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3171129) /Source="Nicolas_upshifts" /id="D1904" /incds=0 /nref=56 /ntot=156 /MaxReadThrough="0.87893" /MaxDrop="6.31542" /score="12.1351765" /energy="-8.7" /TU="NA" /idTUdmin="U2888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 3171141 /Source="Nicolas_upshifts" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3172172..3172190) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3172185) /Source="Nicolas_upshifts" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3172187..3172304) /Source="Nicolas_S_feature" /locus_tag="new_3777796_3777913_c" /HighExp="S8, M40t90, M9-stat, B36, LBGtran, G180, H2O2, M0t90, BT, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigI, SigWXY, SigA" /TUshortPSig="0.947, 0.999, 1, 0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1419" promotor_-35 complement(3172206..3172211) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3172246..3172251 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3172263..3174923 /Source="Nicolas_S_feature" /locus_tag="new_3777872_3780532" /HighExp="S8, S6, S7, S4, S3, C30, S5, T5.0H, T3.30H, BT" /AntisenseName="murAA" /AntisenseCor="5.8371061376981899E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.971" /TUlongSig="NA" /TUlongPSig="NA" /label="S1420" upshifts 3172263 /Source="Nicolas_upshifts" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3172267..3172285 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3172340..3173650) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /EC_number="2.5.1.7" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 14763982, 17714441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14763982, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391557.1" /db_xref="EnsemblGenomes-Gn:BSU36760" /db_xref="EnsemblGenomes-Tr:CAB15693" /db_xref="GOA:P70965" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG11955" /db_xref="UniProtKB/Swiss-Prot:P70965" /translation="MEKIIVRGGQKLNGTVKVEGAKNAVLPVIAASLLASEEKSVICD VPTLSDVYTINEVLRHLGADVHFENNEVTVNASYALQTEAPFEYVRKMRASVLVMGPL LARTGHARVALPGGCAIGSRPIDQHLKGFEAMGAEIKVGNGFIEAEVKGRLQGAKIYL DFPSVGATENLIMAAALAEGTTTLENVAKEPEIVDLANYINGMGGKIRGAGTGTIKIE GVEKLHGVKHHIIPDRIEAGTFMVAAAITEGNVLVKGAVPEHLTSLIAKMEEMGVTIK DEGEGLRVIGPKELKPIDIKTMPHPGFPTDMQSQMMALLLRASGTSMITETVFENRFM HAEEFRRMNGDIKIEGRSVIINGPVQLQGAEVAATDLRAGAALILAGLVAEGHTRVTE LKHLDRGYVDFHQKLAALGADIERVNDESASEQENKEVVSDLNA*" /label="murAA CDS" gene complement(3172340..3173650) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /label="murAA gene" downshifts complement(3172349) /Source="Nicolas_upshifts" /id="D1905" /incds=0 /nref=171 /ntot=256 /MaxReadThrough="5.3301" /MaxDrop="5.5423" /score="31.3825723" /energy="-11.8" /TU="U2890,U2891,U2892,U2894" /idTUdmin="U2890" /TUdmin="-98" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3173674..3173693) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3173681) /Source="Nicolas_upshifts" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3173684..3174424) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391558.1" /db_xref="EnsemblGenomes-Gn:BSU36770" /db_xref="EnsemblGenomes-Tr:CAB15694" /db_xref="InterPro:IPR014794" /db_xref="InterPro:IPR036209" /db_xref="PDB:2FPN" /db_xref="SubtiList:BG12473" /db_xref="UniProtKB/Swiss-Prot:O32277" /translation="MKKKQVSHAIIISVMLSFVIAVFHTIHASELTPLAQMAEGMERQ DVSIDKWTLHAKQNLSLTEKEFYQKVQRLKQEYRQYDWVIAREDKMIKAIGTYTDKKN RTSFRLQLVTTLKKHNPTSYLLYEQMSLETPDSWNDTYEQFERETLGIFQEKVVIFTC LNGHLDDNMNIVLQKKANQLLNEFQARSVEHVVEPNFVSISAFTDEWEEYIMTSKHKM NLQIALRSAGMGGKHTVTVGTPIVTTEY*" /label="ywmB CDS" gene complement(3173684..3174424) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /label="ywmB gene" promotor_-35 complement(3173707..3173716) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3174055) /Source="Nicolas_upshifts" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3174057..3174065) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3174079..3174087) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3174179..3174194) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3174187) /Source="Nicolas_upshifts" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3174207..3174216) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3174425..3174552) /Source="Nicolas_S_feature" /locus_tag="new_3780034_3780161_c" /HighExp="UNK1, S2, Lbexp, MG 60, MG 15, M9-tran, M/G, G135, MG 5, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1421" CDS complement(3174553..3174783) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391559.1" /db_xref="EnsemblGenomes-Gn:BSU36780" /db_xref="EnsemblGenomes-Tr:CAB15695" /db_xref="GOA:O32278" /db_xref="InterPro:IPR009526" /db_xref="SubtiList:BG14163" /db_xref="UniProtKB/Swiss-Prot:O32278" /translation="MSVLGQQAAIGIVVHLIFIAVTWWALQAVNIDPLIKKGKVVQAR LLMILLTIAIGTAVANFFLDYLNYSQQLPYLF*" /label="ywzB CDS" gene complement(3174553..3174783) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /label="ywzB gene" S_feature complement(3174784..3175046) /Source="Nicolas_S_feature" /locus_tag="new_3780393_3780655_c" /HighExp="UNK1, S2, Lbexp, MG 5, M9-tran, M/G, MG 15, MG 60, GM 15, MG t5" /AntisenseName="ywmA" /AntisenseCor="-0.24099136307237601" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1422" misc_feature 3174919..3174938 /Source="Nicolas_upshift_promotors" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3174925 /Source="Nicolas_upshifts" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="upshifts" CDS 3174953..3175426 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391560.1" /db_xref="EnsemblGenomes-Gn:BSU36790" /db_xref="EnsemblGenomes-Tr:CAB15696" /db_xref="SubtiList:BG12472" /db_xref="UniProtKB/Swiss-Prot:P70958" /translation="MNHSFFQPEKQYGEDLPIFDQEWEAIAFYYDYRQSQIEELNELC QFFNISLTYTRESLEELENLYFQSIQELLLADWNLPIEEFEKMISVYLIDCVIARHED AEWVVKPYPYKDGAYTLGFRRHRKSWHTMNACDGLYLRPKEDRPLLSLFDSLVRS*" /label="ywmA CDS" gene 3174953..3175426 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /label="ywmA gene" promotor_-10 complement(3175030..3175049) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-10" upshifts complement(3175046) /Source="Nicolas_upshifts" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="upshifts" S_feature complement(3175048..3175431) /Source="Nicolas_S_feature" /locus_tag="new_3780657_3781040_c" /HighExp="G135, G180, G150, H2O2, Oxctl, Paraq, Cold, M9-stat, C30, S0" /AntisenseName="ywmA" /AntisenseCor="-1.9581968147303098E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1423" promotor_-35 complement(3175064..3175067) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-35" CDS complement(3175460..3175858) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /EC_number="3.6.3.14" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8021203, 12837747, 15347741, 22720735, 23967352" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 12837747, 15347741, 22720735, 23967352; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit epsilon, F1 subunit)" /protein_id="NP_391561.1" /db_xref="EnsemblGenomes-Gn:BSU36800" /db_xref="EnsemblGenomes-Tr:CAB15697" /db_xref="GOA:P37812" /db_xref="InterPro:IPR001469" /db_xref="InterPro:IPR020546" /db_xref="InterPro:IPR020547" /db_xref="InterPro:IPR036771" /db_xref="InterPro:IPR036794" /db_xref="SubtiList:BG10822" /db_xref="UniProtKB/Swiss-Prot:P37812" /translation="MKTVKVNIVTPDGPVYDADIEMVSVRAESGDLGILPGHIPTVAP LKIGAVRLKKDGQTEMVAVSGGFVEVRPDHVTILAQAAETAEGIDKERAEAARQRAQE RLNSQSDDTDIRRAELALQRALNRLDVAGK*" /label="atpC CDS" gene complement(3175460..3175858) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /label="atpC gene" downshifts complement(3175476) /Source="Nicolas_upshifts" /id="D1906" /incds=0 /nref=283 /ntot=320 /MaxReadThrough="4.15968" /MaxDrop="7.84101" /score="22.7623678" /energy="-10.8" /TU="U2897,U2899" /idTUdmin="U2895" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3175850..3175868) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3175859) /Source="Nicolas_upshifts" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3175882..3175888) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3175882..3177303) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit beta, component F1)" /protein_id="NP_391562.1" /db_xref="EnsemblGenomes-Gn:BSU36810" /db_xref="EnsemblGenomes-Tr:CAB15698" /db_xref="GOA:P37809" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005722" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR024034" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10821" /db_xref="UniProtKB/Swiss-Prot:P37809" /translation="MKKGRVSQVLGPVVDVRFEDGHLPEIYNAIKISQPAASENEVGI DLTLEVALHLGDDTVRTIAMASTDGVQRGMEAVDTGAPISVPVGDVTLGRVFNVLGEN IDLNEPVPADAKKDPIHRQAPSFDQLSTEVEILETGIKVVDLLAPYIKGGKIGLFGGA GVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLFYEMSDSGVINKTAMVFGQM NEPPGARMRVALTGLTMAEHFRDVQGQDVLFFIDNIFRFTQAGSEVSALLGRMPSAVG YQPTLATEMGQLQERITSTNVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERK LTEMGIYPAVDPLASTSRALAPEIVGEEHYAVAREVQSTLQRYKELQDIIAILGMDEL GEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKETVQGFKEILAGKYDHLPE DAFRLVGRIEEVVEKAKEMGVEV*" /label="atpD CDS" gene complement(3175882..3177303) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /label="atpD gene" CDS complement(3177329..3178192) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit gamma, component F1)" /protein_id="NP_391563.1" /db_xref="EnsemblGenomes-Gn:BSU36820" /db_xref="EnsemblGenomes-Tr:CAB15699" /db_xref="GOA:P37810" /db_xref="InterPro:IPR000131" /db_xref="InterPro:IPR023632" /db_xref="InterPro:IPR035968" /db_xref="SubtiList:BG10820" /db_xref="UniProtKB/Swiss-Prot:P37810" /translation="MASLRDIKSRITSTKKTSQITKAMQMVSAAKLNRAENNAKSFVP YMDKIQEVVSNVGRVSGNVKHPMLLSREVKKTAYLVITSDRGLAGAFNSSVLRSAYQA MQERHQSKDEYAVIAIGRVGRDFFKKREIPIISELTGLGDEVTFTEIKDLARQTIQMF IDGAFDELHLVYNHFVSAITQEVTEKKLLPLSDLGSGGGKRTASYEFEPSEEEVLEVL LPQYAESLIFGALLDSKASEHAARMTAMKNATDNAKELIDSLSLSYNRARQAAITQEI TEIVGGAAALE*" /label="atpG CDS" gene complement(3177329..3178192) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /label="atpG gene" S_feature complement(3178193..3178268) /Source="Nicolas_S_feature" /locus_tag="new_3783802_3783877_c" /HighExp="S0, S2, MG-0.2, MG-0.1, Mal, G150, BI, M0t45, G180, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1424" CDS complement(3178269..3179777) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit alpha, component F1)" /protein_id="NP_391564.1" /db_xref="EnsemblGenomes-Gn:BSU36830" /db_xref="EnsemblGenomes-Tr:CAB15700" /db_xref="GOA:P37808" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000793" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005294" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033732" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10819" /db_xref="UniProtKB/Swiss-Prot:P37808" /translation="MSIKAEEISTLIKQQIQNYQSDIEVQDVGTVIQVGDGIARVHGL DNCMAGELVEFSNGVLGMAQNLEESNVGIVILGPFSEIREGDEVKRTGRIMEVPVGEE LIGRIVNPLGQPVDGLGPILTSKTRPIESPAPGVMDRKSVHEPLQTGIKAIDALIPIG RGQRELIIGDRQTGKTSVAIDAILNQKDQDMICVYVAIGQKESTVRGVVETLRKHGAL DYTIVVTASASQPAPLLYLAPYAGVTMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLL LRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGAGSITALPFVETQAGDISAYIPTNV ISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGSAQIKAMKKVSGTLRLDLASYREL EAFAQFGSDLDQATQAKLNRGARTVEVLKQDLNKPLPVEKQVAILYALTKGYLDDIPV ADIRRFEEEYYMYLDQNHKDLLDGIAKTGNLPADEDFKAAIEGFKRTFAPSN*" /label="atpA CDS" gene complement(3178269..3179777) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /label="atpA gene" CDS complement(3179794..3180339) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit delta, component F1)" /protein_id="NP_391565.1" /db_xref="EnsemblGenomes-Gn:BSU36840" /db_xref="EnsemblGenomes-Tr:CAB15701" /db_xref="GOA:P37811" /db_xref="InterPro:IPR000711" /db_xref="InterPro:IPR020781" /db_xref="InterPro:IPR026015" /db_xref="SubtiList:BG10818" /db_xref="UniProtKB/Swiss-Prot:P37811" /translation="MSGSAVSKRYASALFDIANESAQLNQVEEELIVVKQVFQNEKAL NDVLNHPKVPAAKKKELIQNAFGSLSQSVLNTIFLLIDRHRAAIVPELTDEFIKLANV ARQTEDAIVYSVKPLTDAEMLPLSQVFAKKAGVASLRIRNEVQTDLIGGIKVRIGNRI YDGSVSGKLQRIERQLAGENR*" /label="atpH CDS" gene complement(3179794..3180339) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /label="atpH gene" CDS complement(3180336..3180848) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit b, component F0)" /protein_id="NP_391566.1" /db_xref="EnsemblGenomes-Gn:BSU36850" /db_xref="EnsemblGenomes-Tr:CAB15702" /db_xref="GOA:P37814" /db_xref="InterPro:IPR002146" /db_xref="InterPro:IPR005864" /db_xref="InterPro:IPR028987" /db_xref="SubtiList:BG10817" /db_xref="UniProtKB/Swiss-Prot:P37814" /translation="MSQLPLELGLSFNGGDILFQLLAMLILLALLKKYALGPLLNIMK QREDHIAGEITSAEEKNKEAQQLIEEQRVLLKEARQESQTLIENAKKLGEKQKEEIIQ AARAESERLKEAARTEIVKEKEQAVSALREQVASLSVMIASKVIEKELDEQAQEKLIQ DYLKEVGESR*" /label="atpF CDS" gene complement(3180336..3180848) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /label="atpF gene" S_feature complement(3180849..3181010) /Source="Nicolas_S_feature" /locus_tag="new_3786458_3786619_c" /HighExp="S2, Lbstat, Mal, M40t90, M0t90, G150, MG-0.1, G135, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1425" CDS complement(3181011..3181223) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit c, component F0)" /protein_id="NP_391567.1" /db_xref="EnsemblGenomes-Gn:BSU36860" /db_xref="EnsemblGenomes-Tr:CAB15703" /db_xref="GOA:P37815" /db_xref="InterPro:IPR000454" /db_xref="InterPro:IPR002379" /db_xref="InterPro:IPR005953" /db_xref="InterPro:IPR020537" /db_xref="InterPro:IPR035921" /db_xref="SubtiList:BG10816" /db_xref="UniProtKB/Swiss-Prot:P37815" /translation="MNLIAAAIAIGLGALGAGIGNGLIVSRTVEGIARQPEAGKELRT LMFMGIALVEALPIIAVVIAFLAFFG*" /label="atpE CDS" gene complement(3181011..3181223) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /label="atpE gene" CDS complement(3181269..3182003) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit a, component F0)" /protein_id="NP_391568.1" /db_xref="EnsemblGenomes-Gn:BSU36870" /db_xref="EnsemblGenomes-Tr:CAB15704" /db_xref="GOA:P37813" /db_xref="InterPro:IPR000568" /db_xref="InterPro:IPR023011" /db_xref="InterPro:IPR035908" /db_xref="SubtiList:BG10815" /db_xref="UniProtKB/Swiss-Prot:P37813" /translation="MNHGYRTIEFLGLTFNLTNILMITVASVIVLLIAILTTRTLSIR PGKAQNFMEWIVDFVRNIIGSTMDLKTGANFLALGVTLLMYIFVSNMLGLPFSITIGH ELWWKSPTADPAITLTLAVMVVALTHYYGVKMKGLKEYSKDYLRPVPFMLPMKIIEEF ANTLTLGLRLYGNIFAGEILLGLLAGLATSHYSQSVALGLVGTIGAILPMLAWQAFSL FIGAIQAFIFTMLTMVYMSHKISHDH*" /label="atpB CDS" gene complement(3181269..3182003) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /label="atpB gene" promotor_no_box 3181817..3181917 /Source="Nicolas_upshift_promotors" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3181877 /Source="Nicolas_upshifts" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3182011..3182394) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /function="16.1: Circulate" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12917488, 15849754, 16850406, 23123906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12917488, 15849754, 16850406, 23123906; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit i)" /protein_id="NP_391569.1" /db_xref="EnsemblGenomes-Gn:BSU36880" /db_xref="EnsemblGenomes-Tr:CAB15705" /db_xref="GOA:P37816" /db_xref="InterPro:IPR005598" /db_xref="SubtiList:BG10814" /db_xref="UniProtKB/Swiss-Prot:P37816" /translation="MDDPKLTFSRQRKYLLFILAVYVLGYGLTAYKTVFLGLILGTVF SLFNFLLLVRRMNAFDRAVEKGKSIRSLGSAARWCNAILAVAVAYKNPEYFHMASTVI GLMTIYPVIMIDSFIQLKRSSMEER*" /label="atpI CDS" gene complement(3182011..3182394) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /label="atpI gene" misc_feature complement(3182083..3182101) /Source="Nicolas_upshift_promotors" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3182085) /Source="Nicolas_upshifts" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3182395..3182665) /Source="Nicolas_S_feature" /locus_tag="new_3788004_3788274_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, UNK1, B60, G135, G180, G150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.96" /label="S1426" promotor_-35 3182627..3182636 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3182636 /Source="Nicolas_upshifts" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3182641..3182660) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" promotor_-10 3182650..3182669 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3182665) /Source="Nicolas_upshifts" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3182667..3182788) /Source="Nicolas_S_feature" /locus_tag="new_3788276_3788397_c" /HighExp="Etha, G180, H2O2, G135, Oxctl, G150, LBGexp, dia15, B36, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.96" /label="S1427" promotor_-35 complement(3182673..3182680) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3182817..3183446) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /EC_number="2.4.2.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7798145, 15689504, 15716449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 15689504, 15716449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil phosphoribosyltransferase" /protein_id="NP_391570.1" /db_xref="EnsemblGenomes-Gn:BSU36890" /db_xref="EnsemblGenomes-Tr:CAB15706" /db_xref="GOA:P39149" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005765" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR034332" /db_xref="SubtiList:BG10945" /db_xref="UniProtKB/Swiss-Prot:P39149" /translation="MGKVYVFDHPLIQHKLTYIRNENTGTKDFRELVDEVATLMAFEI TRDLPLEEVDINTPVQAAKSKVISGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGL YRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEAIHSLKKRGAKNIRFMCL VAAPEGVEELQKHHSDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK*" /label="upp CDS" gene complement(3182817..3183446) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /label="upp gene" downshifts complement(3182833) /Source="Nicolas_upshifts" /id="D1907" /incds=0 /nref=180 /ntot=252 /MaxReadThrough="5.83241" /MaxDrop="5.91252" /score="1.39547358" /energy="-7.3" /TU="U2900,U2901" /idTUdmin="U2900" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3183490..3183509) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" upshifts complement(3183513) /Source="Nicolas_upshifts" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" promotor_-35 complement(3183524..3183531) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3183581..3184828) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /EC_number="2.1.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine hydroxymethyltransferase" /protein_id="NP_391571.1" /db_xref="EnsemblGenomes-Gn:BSU36900" /db_xref="EnsemblGenomes-Tr:CAB15707" /db_xref="GOA:P39148" /db_xref="InterPro:IPR001085" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR019798" /db_xref="SubtiList:BG10944" /db_xref="UniProtKB/Swiss-Prot:P39148" /translation="MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQG SVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRAKEIFGAEHVNVQPHSGAQANMAVY FTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKAL AHKPKLIVAGASAYPRTIDFKKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYAD FVTTTTHKTLRGPRGGMILCREEFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQD DFKTYAQNVISNAKRLAEALTKEGIQLVSGGTDNHLILVDLRSLGLTGKVAEHVLDEI GITSNKNAIPYDPEKPFVTSGIRLGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGK LEEARQRVAALTDKFPLYKELDY*" /label="glyA CDS" gene complement(3183581..3184828) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /label="glyA gene" downshifts complement(3183604) /Source="Nicolas_upshifts" /id="D1908" /incds=0 /nref=183 /ntot=229 /MaxReadThrough="5.99283" /MaxDrop="6.62881" /score="22.1245386" /energy="-15.8" /TU="U2901" /idTUdmin="U2902" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3184870..3184889) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3184887) /Source="Nicolas_upshifts" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3184889..3184973) /Source="Nicolas_S_feature" /locus_tag="new_3790498_3790582_c" /HighExp="dia5, C90, dia15, Diami, Lbtran, LPhT, M40t45, H2O2, BI, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1428" promotor_-35 complement(3184904..3184909) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3185018) /Source="Nicolas_upshifts" /id="D1909" /incds=0 /nref=3 /ntot=12 /MaxReadThrough="7.23859" /MaxDrop="5.0386" /score="-3.86767322" /energy="-4.3" /TU="U2902,U2903" /idTUdmin="U2904" /TUdmin=1137 /isTUend="FALSE" /label="downshifts" CDS complement(3185035..3185577) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391572.1" /db_xref="EnsemblGenomes-Gn:BSU36910" /db_xref="EnsemblGenomes-Tr:CAB15708" /db_xref="InterPro:IPR006340" /db_xref="InterPro:IPR028345" /db_xref="SubtiList:BG10943" /db_xref="UniProtKB/Swiss-Prot:P39157" /translation="MNELKQTWKTMLSEFQDQAELKQDQLFVLGCSTSEVAGSRIGTS GSVDIAESIYSGLAELREKTGIHLAFQCCEHLNRALVVEAETAKLFRLPTVSAVPVPK AGGAMASYAFKQMKSPVLVETIQADAGIDIGDTFIGMHLKPVAVPVRVSQNSLGSAHV TLARTRPKLIGGVRAVYECE*" /label="ywlG CDS" gene complement(3185035..3185577) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /label="ywlG gene" CDS complement(3185590..3186039) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /EC_number="5.3.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15755726, 15995210, 18640127, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 15995210, 18640127, 19446032; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose 5-phosphate epimerase (promiscuous)" /protein_id="NP_391573.1" /db_xref="EnsemblGenomes-Gn:BSU36920" /db_xref="EnsemblGenomes-Tr:CAB15709" /db_xref="GOA:P39156" /db_xref="InterPro:IPR003500" /db_xref="InterPro:IPR004785" /db_xref="InterPro:IPR036569" /db_xref="SubtiList:BG10942" /db_xref="UniProtKB/Swiss-Prot:P39156" /translation="MKVAIASDHGGVHIRNEIKELMDELQIEYIDMGCDCGSGSVDYP DYAFPVAEKVVSGEVDRGILICGTGIGMSISANKVKGIRCALAHDTFSAKATREHNDT NILAMGERVIGPGLAREIAKIWLTTEFTGGRHQTRIGKISDYEEKNL*" /label="rpiB CDS" gene complement(3185590..3186039) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /label="rpiB gene" S_feature complement(3186040..3186139) /Source="Nicolas_S_feature" /locus_tag="new_3791649_3791748_c" /HighExp="Diami, dia5, C90, dia15, LPhT, M40t45, LBGtran, Lbtran, T-0.40H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.68276199999999998" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1429" promotor_-10 complement(3186131..3186150) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-10" upshifts complement(3186139) /Source="Nicolas_upshifts" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="upshifts" promotor_-35 complement(3186164..3186171) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-35" CDS complement(3186196..3186648) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /EC_number="3.9.1.2" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210, 22517742, 24825175, 25610436, 27524296" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210, 22517742, 24825175, 25610436, 27524296; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-arginine(tyrosine moonlighting) phosphatase (oxidative stress)" /protein_id="NP_391574.1" /db_xref="EnsemblGenomes-Gn:BSU36930" /db_xref="EnsemblGenomes-Tr:CAB15710" /db_xref="GOA:P39155" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1ZGG" /db_xref="PDB:4ETI" /db_xref="PDB:4ETN" /db_xref="PDB:4KK3" /db_xref="PDB:4KK4" /db_xref="SubtiList:BG10941" /db_xref="UniProtKB/Swiss-Prot:P39155" /translation="MDIIFVCTGNTCRSPMAEALFKSIAEREGLNVNVRSAGVFASPN GKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLAMTHQHKQIIASQFGRYRDKV FTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKKDRR*" /label="prpB CDS" gene complement(3186196..3186648) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /label="prpB gene" promotor_-10 complement(3186665..3186684) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-10" upshifts complement(3186683) /Source="Nicolas_upshifts" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="upshifts" promotor_-35 complement(3186699..3186702) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-35" CDS complement(3186724..3187281) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 25774656, 25794618, 26076491; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="manganese efflux pump" /protein_id="NP_391575.1" /db_xref="EnsemblGenomes-Gn:BSU36940" /db_xref="EnsemblGenomes-Tr:CAB15711" /db_xref="GOA:P39154" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR022929" /db_xref="SubtiList:BG10940" /db_xref="UniProtKB/Swiss-Prot:P39154" /translation="MSDLFIGELITLSIMAFALGMDAFSVGLGMGMVKLRKKQIFYIG FIIGLFHVIMPLAGMAAGNMLSGLLGVLAVYIGGALLFVLGVQMLMASFKQSEERFMS PAGPGLLLFAIGVSLDSFSVGLSLGIYGSHPLLTITLFGLFSMMLTWLGLLVGKQVQS WLGTYSEALGGIILIVFGLKLLLPI*" /label="mntP CDS" gene complement(3186724..3187281) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /label="mntP gene" promotor_-10 complement(3187308..3187326) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-10" upshifts complement(3187321) /Source="Nicolas_upshifts" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="upshifts" promotor_-35 complement(3187342..3187347) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-35" CDS complement(3187360..3188400) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; threonine-dependent ADP-forming ATPase" /protein_id="NP_391576.1" /db_xref="EnsemblGenomes-Gn:BSU36950" /db_xref="EnsemblGenomes-Tr:CAB15712" /db_xref="GOA:P39153" /db_xref="InterPro:IPR005145" /db_xref="InterPro:IPR006070" /db_xref="InterPro:IPR010923" /db_xref="InterPro:IPR017945" /db_xref="SubtiList:BG10939" /db_xref="UniProtKB/Swiss-Prot:P39153" /translation="MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGL GANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLEDLTGPAPEKAKTLMKRFWPGAL TLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTK AEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIH VDKGLSDQNEKPISPGMKYTHYAPTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTE EKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIAESFPDTGVGLAIMN RLMKAAGGRVIR*" /label="tsaC CDS" gene complement(3187360..3188400) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /label="tsaC gene" downshifts complement(3187365) /Source="Nicolas_upshifts" /id="D1910" /incds=0 /nref=4 /ntot=166 /MaxReadThrough="2.08557" /MaxDrop="2.98653" /score="-6.24994287" /energy="-9.8" /TU="NA" /idTUdmin="U2905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3188401..3188465) /Source="Nicolas_S_feature" /locus_tag="new_3794010_3794074_c" /HighExp="dia15, Diami, C90, LBGstat, Heat, LBGtran, dia5, LBGexp, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1430" promotor_-10 complement(3188455..3188474) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3188465) /Source="Nicolas_upshifts" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3188467..3188556) /Source="Nicolas_S_feature" /locus_tag="new_3794076_3794165_c" /HighExp="S3, M9-stat, Etha, LoTm, T5.0H, S7, S8, S4, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1431" promotor_-35 complement(3188490..3188494) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3188557..3189000) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391577.1" /db_xref="EnsemblGenomes-Gn:BSU36960" /db_xref="EnsemblGenomes-Tr:CAB15713" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10938" /db_xref="UniProtKB/Swiss-Prot:P39152" /translation="MFYQLRVAREKDGDVLEAFLKQAKTSYEGVKEGFTQFLMLEDSE KNIAGCLGIEKISCDQGLLRSLVISDKLHQGHIVTLFQSMEVLCEKHQIKTVYLVANQ HSSADFLTAMGFERAESVPEELFSSDHFCESRQTEGAVLMKKASG*" /label="ywlB CDS" gene complement(3188557..3189000) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /label="ywlB gene" CDS complement(3189067..3189741) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15044948, 16824103, 18378688, 20802044, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15044948, 16824103, 18378688, 20802044, 22111992; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator signal of pro-sigma(E) spoIIGA endopeptidase (stage II sporulation)" /protein_id="NP_391578.1" /db_xref="EnsemblGenomes-Gn:BSU36970" /db_xref="EnsemblGenomes-Tr:CAB15714" /db_xref="GOA:P39151" /db_xref="InterPro:IPR014202" /db_xref="SubtiList:BG10937" /db_xref="UniProtKB/Swiss-Prot:P39151" /translation="MKKTVIICIYIFLLLSGALVGLAKEETAQKSENQPVVIPDQAIR LRILANSDSDQDQQLKRHIRDAVNKEITTWVKDITSIEEARRVIRSKLPEIKAIAKET MEKEGANQSISVDFDKISFPTKLYGNMVYPAGEYEAILITLGNGDGANWWCVLFPPLC FLDFSNGEAVKEQEDKEASKKQTEKVLEDVTAKAEKAKKEENEEKEDGTEVKFFLVEW ISDLFS*" /label="spoIIR CDS" gene complement(3189067..3189741) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /label="spoIIR gene" promotor_-10 complement(3189503..3189521) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3189510) /Source="Nicolas_upshifts" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3189536..3189542) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3189773..3189790) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3189774) /Source="Nicolas_upshifts" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3189806..3189811) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3189847 /Source="Nicolas_upshifts" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3189851..3189870 /Source="Nicolas_upshift_promotors" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3189882..3190244 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391579.1" /db_xref="EnsemblGenomes-Gn:BSU36980" /db_xref="EnsemblGenomes-Tr:CAB15715" /db_xref="GOA:P39150" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG10936" /db_xref="UniProtKB/Swiss-Prot:P39150" /translation="MKYNYTVLLSAFTMSVLYSVIYIHSFIIAALITMAFYFLFPYLI FALPLQIMMNKKPKRFSPLYLLYYLAAAFIANAIIFGMLQPSGQSLFQNTAFYLFAVL TALIYWIWDSVLLQKKEA*" /label="ywlA CDS" gene 3189882..3190244 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /label="ywlA gene" downshifts complement(3190257) /Source="Nicolas_upshifts" /id="D1911" /incds=0 /nref=27 /ntot=242 /MaxReadThrough="2.64328" /MaxDrop="5.72616" /score="26.8558862" /energy="-11.3" /TU="U2910" /idTUdmin="U2909" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3190261..3190548) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391580.1" /db_xref="EnsemblGenomes-Gn:BSU36990" /db_xref="EnsemblGenomes-Tr:CAB15716" /db_xref="GOA:P45874" /db_xref="InterPro:IPR035167" /db_xref="SubtiList:BG11317" /db_xref="UniProtKB/Swiss-Prot:P45874" /translation="MKKALTAGILLIAIESMIGTIFPQALSYEAIFGVASLVLVGLAI ITSGLAVSGSDQRANYHSETKEGRTSRMKMAAAFFVAAIPSILCYLLTILF*" /label="ywkF CDS" gene complement(3190261..3190548) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /label="ywkF gene" S_feature complement(3190549..3190607) /Source="Nicolas_S_feature" /locus_tag="new_3796158_3796216_c" /HighExp="S6, S8, S7, BT, G135, G180, Paraq, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1432" promotor_-10 complement(3190605..3190624) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3190608..3191474) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /EC_number="2.1.1.297" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 16364916, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine methylase of release factor 1 (and perhaps others) at a GGQ site" /protein_id="NP_391581.1" /db_xref="EnsemblGenomes-Gn:BSU37000" /db_xref="EnsemblGenomes-Tr:CAB15717" /db_xref="GOA:P45873" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004556" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR019874" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11316" /db_xref="UniProtKB/Swiss-Prot:P45873" /translation="MKTIFEALKWASSYLTEAGREENAAELLLLYDTGMERSKLLASL QEPIGEDELYRFKRHVEMHKEGVPVQYIIGKEFFYGREFMVNDDVLIPRPETEEVVFH LLEKYRSVFSEDGKLEVVDVGTGSGAIAVTLALENQSFSVSAVDISKEALQVASANAE KLGANVRFYQGDLLEPFIKAGKKADIIVSNPPYISEEEMADLSEIVRFHEPLHALTDG GDGLKFYKRFMEDIPLVMKDKVFVVFEIGWKQGAAVKDLILKAFKGAEVEVLKDINGK DRTICALIHKNK*" /label="prmC CDS" gene complement(3190608..3191474) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /label="prmC gene" upshifts complement(3190621) /Source="Nicolas_upshifts" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3190637..3190646) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3191476..3192546) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /experiment="publication(s) with functional evidences, PMID:2186375, 1408743, 10446248, 12237459, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2186375, 1408743, 10446248, 12237459, 12682299; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 1" /protein_id="NP_391582.1" /db_xref="EnsemblGenomes-Gn:BSU37010" /db_xref="EnsemblGenomes-Tr:CAB15718" /db_xref="GOA:P45872" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004373" /db_xref="InterPro:IPR005139" /db_xref="SubtiList:BG11244" /db_xref="UniProtKB/Swiss-Prot:P45872" /translation="MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQET VDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEEISELQKETETLSERLKVLLIPK DPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEK DIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARI YDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQILEGK LDEVVEALIVEDQASKLQQSEG*" /label="prfA CDS" gene complement(3191476..3192546) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /label="prfA gene" downshifts complement(3191479) /Source="Nicolas_upshifts" /id="D1912" /incds=0 /nref=23 /ntot=212 /MaxReadThrough="5.17118" /MaxDrop="3.44681" /score="-9.55295942" /energy="-10.5" /TU="U2910" /idTUdmin="U2912" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" downshifts 3192547 /Source="Nicolas_upshifts" /id="D1913" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.13519" /MaxDrop="4.28706" /score="36.3991981" /energy="-10.4" /TU="NA" /idTUdmin="U2911" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3192574..3192593) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3192598) /Source="Nicolas_upshifts" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3192600..3192711) /Source="Nicolas_S_feature" /locus_tag="new_3798209_3798320_c" /HighExp="S6, S8, S7, BT, S5, Etha, B36, C30, S4, GM 25" /AntisenseName="ywkD" /AntisenseCor="-0.43140174721346802" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.927" /TUlongSig="NA" /TUlongPSig="NA" /label="S1433" promotor_-35 complement(3192607..3192613) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3192643..3192662 /Source="Nicolas_upshift_promotors" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3192657 /Source="Nicolas_upshifts" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3192672..3193058 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391583.1" /db_xref="EnsemblGenomes-Gn:BSU37020" /db_xref="EnsemblGenomes-Tr:CAB15719" /db_xref="GOA:P45871" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11315" /db_xref="UniProtKB/Swiss-Prot:P45871" /translation="MLLKSIHHIAIICSDYEKSKAFYVHKLGFQVIQETYREERGSYK LDLSLNGSYVIELFSFPDPPERQTRPEAAGLRHLAFTVGSLDKAVQELHEKGIETEPI RTDPLTGKRFTFFFDPDQLPLELYEQ*" /label="ywkD CDS" gene 3192672..3193058 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /label="ywkD gene" promotor_-10 complement(3192693..3192711) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-10" upshifts complement(3192711) /Source="Nicolas_upshifts" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="upshifts" promotor_-35 complement(3192725..3192732) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-35" promotor_-35 3193126..3193134 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3193145..3193163 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3193146 /Source="Nicolas_upshifts" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3193180..3193734 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15780934, 17139259, 19478798, 22720735, 27059541, 27085804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15780934, 17139259, 19478798, 22720735, 27059541, 27085804; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome-pole-anchoring protein RacA" /protein_id="NP_391584.1" /db_xref="EnsemblGenomes-Gn:BSU37030" /db_xref="EnsemblGenomes-Tr:CAB15720" /db_xref="GOA:P45870" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR023522" /db_xref="PDB:5I41" /db_xref="PDB:5I44" /db_xref="SubtiList:BG11314" /db_xref="UniProtKB/Swiss-Prot:P45870" /translation="MNTNMVASELGVSAKTVQRWVKQLNLPAERNELGHYSFTAEDVK VLKSVQKQISEGTAIQDIHLPKSAKKRTGFLVQKTSSDTERRIEQLEQKLDTLLQQRQ DESELMARMSELERQLKQKADEGVSYQLLQHRREIDDILADLQSLTSQMKEFTAHSIP ETAAASEKTKTRKKPLLSLFKFQT*" /label="racA CDS" gene 3193180..3193734 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /label="racA gene" misc_feature 3193664..3193668 /Source="Nicolas_upshift_promotors" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3193669 /Source="Nicolas_upshifts" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3193713 /Source="Nicolas_upshifts" /id="D1914" /incds=0 /nref=213 /ntot=274 /MaxReadThrough="0.82868" /MaxDrop="8.28021" /score="36.3991981" /energy="-10.4" /TU="U2913" /idTUdmin="U2914" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3193768..3194727) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12949160, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391585.1" /db_xref="EnsemblGenomes-Gn:BSU37040" /db_xref="EnsemblGenomes-Tr:CAB15721" /db_xref="GOA:P45869" /db_xref="InterPro:IPR004776" /db_xref="InterPro:IPR014024" /db_xref="SubtiList:BG11313" /db_xref="UniProtKB/Swiss-Prot:P45869" /translation="MSILDILILLAPIFFVIVLGWFAGHFGSYDAKSAKGVSTLVTKY ALPAHFIAGILTTSRSEFLSQVPLMISLIIGIVGFYIIILLVCRFIFKYDLTNSSVFS LNSAQPTFAFMGIPVLGSLFGANEVAIPIAVTGIVVNAILDPLAIIIATVGESSKKNE ESGDSFWKMTGKSILHGLCEPLAAAPLISMILVLVFNFTLPELGVKMLDQLGSTTSGV ALFAVGVTVGIRKIKLSMPAIGIALLKVAVQPALMFLIALAIGLPADQTTKAILLVAF PGSAVAAMIATRFEKQEEETATAFVVSAILSLISLPIIIALTA*" /label="ywkB CDS" gene complement(3193768..3194727) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /label="ywkB gene" downshifts complement(3193790) /Source="Nicolas_upshifts" /id="D1915" /incds=0 /nref=36 /ntot=74 /MaxReadThrough="2.86006" /MaxDrop="4.78642" /score="20.048754" /energy="-10.4" /TU="U2916" /idTUdmin="U2917" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3194765..3194783) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3194779) /Source="Nicolas_upshifts" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3194798..3194804) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3194809..3196557) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12949160, 16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949160, 16788182, 20933603, 22740702, 23136871, 24325460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_391586.1" /db_xref="EnsemblGenomes-Gn:BSU37050" /db_xref="EnsemblGenomes-Tr:CAB15722" /db_xref="GOA:P45868" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11312" /db_xref="UniProtKB/Swiss-Prot:P45868" /translation="MGYYLTWLTISRKKEICLNNIKKTKEGHLETTLRGKEVLSIPTL NKGVAFSLEERQELGLEGLLPPTVLSLDQQAQRAYEQFQAQPDRLRQNVYLSDLANRN EVLFYKLLKNHLREMLPVVYTPTVGEAIQEYSHEYRRPQGIYLSIDNIDGIEKAFENL HATAGDIDLIVATDSESILGIGDWGVGGINIAIGKLAVYTAAAGIDPSRVIPVVLDVG TNNEKLLNDPLYIGNKHERVQGERYEAFIDAYVKAALKFFPKALLHWEDLGNKNARNI MKKYNHEILTFNDDIQGTGAITLAGVLAAMKKTGASIKDQRVVIFGAGSAGIGIADQI RDTMVLAGLSEEEANKRFYTLDYRGLLTEDIEGILDFQKPYLRNADEVKDWKRDEKGQ IPFDEVVRQAKPTILIGTSGVSGAFTEEIVKEMASHVDRPVIMPMSNPTHLAEAVPED LFKWTDGKVLIATGSPFDNVEYNGVSYEIGQSNNAFAFPGLGLGSIVAEARIITPAMF AATADAIAEMVDLETPGAGLLPSIDKLQEVSIQVAIAVAEAAIKDGVANRQPEDVKQA VLDAMWTPEYKKVIAK*" /label="maeA CDS" gene complement(3194809..3196557) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /label="maeA gene" promotor_-10 complement(3195283..3195301) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3195291) /Source="Nicolas_upshifts" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3195316..3195322) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3196558..3196648) /Source="Nicolas_S_feature" /locus_tag="new_3802167_3802257_c" /HighExp="GM 25, GM 15, GM 60, GM 90, GM 120, MG-0.2, MG 15, GM 45, MG-0.1, GM 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1434" promotor_-10 complement(3196632..3196651) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3196648) /Source="Nicolas_upshifts" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3196665..3196672) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3196791) /Source="Nicolas_upshifts" /id="D1916" /incds=0 /nref=11 /ntot=126 /MaxReadThrough="2.81368" /MaxDrop="3.39095" /score="20.3711149" /energy="-7.5" /TU="NA" /idTUdmin="U2918" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(3196796..3197383) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /EC_number="2.7.1.21" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2423635, 17132103; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidine kinase" /protein_id="NP_391587.1" /db_xref="EnsemblGenomes-Gn:BSU37060" /db_xref="EnsemblGenomes-Tr:CAB15723" /db_xref="GOA:Q03221" /db_xref="InterPro:IPR001267" /db_xref="InterPro:IPR020633" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10419" /db_xref="UniProtKB/Swiss-Prot:Q03221" /translation="MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKP VIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLS SLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLID GKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK*" /label="tdk CDS" gene complement(3196796..3197383) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /label="tdk gene" CDS complement(3197472..3197672) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_391588.1" /db_xref="EnsemblGenomes-Gn:BSU37070" /db_xref="EnsemblGenomes-Tr:CAB15724" /db_xref="GOA:Q03223" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027491" /db_xref="InterPro:IPR034704" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10417" /db_xref="UniProtKB/Swiss-Prot:Q03223" /translation="MKAGIHPNFKKATVKCACGNEFETGSVKEEVRVEICSECHPFYT GRQKFASADGRVDRFNKKYGLK*" /label="rpmEA CDS" gene complement(3197472..3197672) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /label="rpmEA gene" downshifts complement(3197485) /Source="Nicolas_upshifts" /id="D1917" /incds=0 /nref=268 /ntot=279 /MaxReadThrough="5.35148" /MaxDrop="6.82076" /score="15.63162" /energy="-10.3" /TU="U2918,U2919" /idTUdmin="U2921" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3197673..3197750) /Source="Nicolas_S_feature" /locus_tag="new_3803282_3803359_c" /HighExp="HPh, LPh, LPhT, GM 45, Paraq, MG 45, MG 60, aero, LBGexp, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1435" promotor_-10 complement(3197746..3197765) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3197750) /Source="Nicolas_upshifts" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3197779..3197786) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3197791..3199074) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10027981, 16014871, 18852477, 28520932, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10027981, 16014871, 18852477, 28520932, 28723971; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcriptional terminator Rho" /protein_id="NP_391589.2" /db_xref="EnsemblGenomes-Gn:BSU37080" /db_xref="EnsemblGenomes-Tr:CAB15725" /db_xref="GOA:Q03222" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004665" /db_xref="InterPro:IPR011112" /db_xref="InterPro:IPR011113" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036269" /db_xref="SubtiList:BG10416" /db_xref="UniProtKB/Swiss-Prot:Q03222" /translation="MKDVSISSLENMKLKELYELARHYKISYYSKLTKKELIFAILKA NAEQEDLLFMEGVLEIIQSEGFGFLRPINYSPSSEDIYISASQIRRFDLRNGDKVSGK VRPPKENERYYGLLHVEAVNGDDPESAKERVHFPALTPLYPDRQMVLETKPNFLSTRI MDMMAPVGFGQRGLIVAPPKAGKTMLLKEIANSITANQPEAELIVLLIDERPEEVTDI ERSVAGDVVSSTFDEVPENHIKVAELVLERAMRLVEHKKDVIILMDSITRLARAYNLV IPPSGRTLSGGIDPAAFHRPKRFFGAARNIEEGGSLTILATALVDTGSRMDDVIYEEF KGTGNMELHLDRSLAERRIFPAIDIRRSGTRKEELLVPKEHLDRLWSIRKTMSDSPDF AEKFMRKMKKTKTNQEFFDILNQEWKQANLSSARR*" /label="rho CDS" gene complement(3197791..3199074) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /label="rho gene" S_feature complement(3199075..3199377) /Source="Nicolas_S_feature" /locus_tag="new_3804684_3804986_c" /HighExp="H2O2, Cold, G135, HPh, G180, G150, LBGstat, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1436" CDS complement(3199105..3199266) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 20525796" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514010.1" /db_xref="EnsemblGenomes-Gn:BSU37089" /db_xref="EnsemblGenomes-Tr:CCQ48606" /db_xref="UniProtKB/TrEMBL:L8EA05" /translation="MFLSSLPSKLIKTILLTKAPIMGGSVTDRSSFMLKKECALADVV QKQQMTCSE*" /label="hypothetical protein CDS" gene complement(3199105..3199266) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /label="gene" promotor_-10 complement(3199357..3199376) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3199377) /Source="Nicolas_upshifts" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3199392..3199396) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3199481..3200446) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /EC_number="3.1.3.11" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose 1,6-bisphosphatase class II" /protein_id="NP_391590.1" /db_xref="EnsemblGenomes-Gn:BSU37090" /db_xref="EnsemblGenomes-Tr:CAB15726" /db_xref="GOA:Q03224" /db_xref="InterPro:IPR004464" /db_xref="SubtiList:BG10415" /db_xref="UniProtKB/Swiss-Prot:Q03224" /translation="MERSLSMELVRVTEAAALASARWMGRGKKDEADEAATSAMRDVF DTVPMKGTVVIGEGEMDEAPMLYIGEKLGNGYGPRVDVAVDPLEGTNILASGGWNALT VIAVADHGTLLNAPDMYMQKIAVGPEAVGCIDIEAPVIDNLKAVAKAKNKDVEDVVAT ILNRERHAKIISELREAGARIKLINDGDVAGAINTAFDHTGVDILFGSGGAPEGVLSA VALKALGGEIIGKLLPQSEEEITRCHKMGLDLSKVLRMEDLVKGDDAIFAATGVTDGE LLKGVQFKGSVGTTESLVIRAKSGTVRFVDGRHSLKKKPNLVIRP*" /label="glpX CDS" gene complement(3199481..3200446) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /label="glpX gene" downshifts complement(3199487) /Source="Nicolas_upshifts" /id="D1918" /incds=0 /nref=56 /ntot=196 /MaxReadThrough="5.42698" /MaxDrop="5.21817" /score="-2.15106481" /energy="-10.2" /TU="U2921,U2922" /idTUdmin="U2922" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 3200063..3200072 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3200085..3200104 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3200093 /Source="Nicolas_upshifts" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3200477..3201766) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /EC_number="2.5.1.7" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14763982, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14763982, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391591.2" /db_xref="EnsemblGenomes-Gn:BSU37100" /db_xref="EnsemblGenomes-Tr:CAB15727" /db_xref="GOA:P19670" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10414" /db_xref="UniProtKB/Swiss-Prot:P19670" /translation="MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGL PEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMISMPLPNGKVKKLRASYYLMGAML GRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDV VSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGV KELHGCKHTIIPDRIEAGTFMIAGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETS DDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGTSVVTDTIYSARFKH IDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGL EHIDRGYSSLEKKLEGLGATIWRERMTDEEIEQLQNS*" /label="murAB CDS" gene complement(3200477..3201766) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /label="murAB gene" S_feature complement(3201767..3202126) /Source="Nicolas_S_feature" /locus_tag="new_3807376_3807735_c" /HighExp="dia5, Fru, UNK1, Glucon, HiOs, T-5.40H, nit, SMM, MG 120, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16076699999999999" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1437" CDS complement(3202145..3202783) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /EC_number="2.2.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 12469342, 22212631, 23468065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 12469342, 22212631, 23468065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transaldolase" /protein_id="NP_391592.3" /db_xref="EnsemblGenomes-Gn:BSU37110" /db_xref="EnsemblGenomes-Tr:CAB15728" /db_xref="GOA:P19669" /db_xref="InterPro:IPR001585" /db_xref="InterPro:IPR004731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018225" /db_xref="InterPro:IPR022999" /db_xref="InterPro:IPR033919" /db_xref="PDB:3R8R" /db_xref="SubtiList:BG10413" /db_xref="UniProtKB/Swiss-Prot:P19669" /translation="MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRL REITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLG IKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQ IIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK*" /label="tal CDS" gene complement(3202145..3202783) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /label="tal gene" downshifts complement(3202171) /Source="Nicolas_upshifts" /id="D1919" /incds=0 /nref=6 /ntot=65 /MaxReadThrough="6.97243" /MaxDrop="4.038" /score="-6.93331064" /energy="-18.4" /TU="U2921,U2922" /idTUdmin="U2926" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" S_feature complement(3202784..3202902) /Source="Nicolas_S_feature" /locus_tag="new_3808393_3808511_c" /HighExp="dia5, LBGtran, M40t45, Lbtran, Mt0, M40t90, M0t45, Lbstat, Lbexp, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1438" CDS complement(3202903..3203760) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /EC_number="4.1.2.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphate aldolase" /protein_id="NP_391593.1" /db_xref="EnsemblGenomes-Gn:BSU37120" /db_xref="EnsemblGenomes-Tr:CAB15729" /db_xref="GOA:P13243" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10412" /db_xref="UniProtKB/Swiss-Prot:P13243" /translation="MPLVSMTEMLNTAKEKGYAVGQFNLNNLEFTQAILQAAEEEKSP VILGVSEGAGRYMGGFKTVVAMVKALMEEYKVTVPVAIHLDHGSSFESCAKAIHAGFT SVMIDASHHPFEENVATTAKVVELAHFHGVSVEAELGTVGGQEDDVIAEGVIYADPKE CQELVERTGIDCLAPALGSVHGPYKGEPNLGFKEMEEIGKSTGLPLVLHGGTGIPTAD IKKSISLGTAKINVNTENQISSAKAVRETLAAKPDEYDPRKYLGPAREAIKETVIGKM REFGSSNQA*" /label="fbaA CDS" gene complement(3202903..3203760) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /label="fbaA gene" S_feature complement(3203761..3203887) /Source="Nicolas_S_feature" /locus_tag="new_3809370_3809496_c" /HighExp="C90, Lbtran, LBGtran, dia5, LBGexp, aero, M0t90, Glu, Lbexp, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1439" promotor_-10 complement(3203869..3203888) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-10" upshifts complement(3203887) /Source="Nicolas_upshifts" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="upshifts" promotor_-35 complement(3203902..3203909) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-35" CDS complement(3203941..3204315) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator of sporulation initiation" /protein_id="NP_391594.1" /db_xref="EnsemblGenomes-Gn:BSU37130" /db_xref="EnsemblGenomes-Tr:CAB15730" /db_xref="GOA:P06628" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="PDB:1F51" /db_xref="PDB:1FSP" /db_xref="PDB:1NAT" /db_xref="PDB:1PEY" /db_xref="PDB:1PUX" /db_xref="PDB:1SRR" /db_xref="PDB:2FSP" /db_xref="PDB:2FTK" /db_xref="PDB:2JVI" /db_xref="PDB:2JVJ" /db_xref="PDB:2JVK" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG10411" /db_xref="UniProtKB/Swiss-Prot:P06628" /translation="MMNEKILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVT KERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYGELDMIQESKELGALTHF AKPFDIDEIRDAVKKYLPLKSN*" /label="spo0F CDS" gene complement(3203941..3204315) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /label="spo0F gene" promotor_-10 complement(3204355..3204373) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3204369) /Source="Nicolas_upshifts" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="upshifts" S_feature complement(3204371..3205010) /Source="Nicolas_S_feature" /locus_tag="new_3809980_3810619_c" /HighExp="dia15, Diami, dia5, G135, Etha, G150, G180, Salt, H2O2, Paraq" /AntisenseName="ywjG" /AntisenseCor="0.58536525532649697" /AntisenseRegPval="-25.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1440" promotor_-35 3204372..3204375 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3204384..3204392) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" promotor_-10 3204391..3204410 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3204404 /Source="Nicolas_upshifts" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3204418..3204423 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3204439..3204458 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3204449 /Source="Nicolas_upshifts" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" CDS 3204481..3205002 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391595.1" /db_xref="EnsemblGenomes-Gn:BSU37140" /db_xref="EnsemblGenomes-Tr:CAB15731" /db_xref="InterPro:IPR019676" /db_xref="SubtiList:BG11053" /db_xref="UniProtKB/Swiss-Prot:P06629" /translation="MLKIFTTQLTGIFSRIQDKESDAIEDGARLLAQAVISGHSIYLY GANELQGVFYEATESKEPFPSVKAFPENAEEVTESDRVLMFCSGTGTAEEQELAKELY EKGAGVVCVSPAAKDSAGIEQYCDVHIDSKLKMPLVPDEDGTRYGFPSLMTALYVYHA LSFTLKEILQEYA*" /label="ywjG CDS" gene 3204481..3205002 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /label="ywjG gene" promotor_-35 3204945..3204948 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3204963..3204982 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3204977 /Source="Nicolas_upshifts" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3205000..3205019) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3205010) /Source="Nicolas_upshifts" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="upshifts" downshifts 3205021 /Source="Nicolas_upshifts" /id="D1920" /incds=0 /nref=191 /ntot=242 /MaxReadThrough="1.98527" /MaxDrop="5.8354" /score="11.5531593" /energy="-11.9" /TU="NA" /idTUdmin="U2923" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3205034..3205041) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" CDS complement(3205084..3206691) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /EC_number="6.3.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11544212, 15252202, 17158658, 17302819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544212, 15252202, 17158658, 17302819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CTP synthetase" /protein_id="NP_391596.1" /db_xref="EnsemblGenomes-Gn:BSU37150" /db_xref="EnsemblGenomes-Tr:CAB15743" /db_xref="GOA:P13242" /db_xref="InterPro:IPR004468" /db_xref="InterPro:IPR017456" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033828" /db_xref="SubtiList:BG10410" /db_xref="UniProtKB/Swiss-Prot:P13242" /translation="MTKYIFVTGGVVSSLGKGIVAASLGRLLKNRGLNVTIQKFDPYI NVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTTGKIYSTVLKKE RRGDYLGGTVQVIPHITNELKDRVYRAGKETNADVVITEIGGTVGDIESLPFLEAIRQ MKSDIGRENVMYIHCTLVPYIKAAGELKTKPTQHSVKELRSLGIQPNIIVVRTEMPIS QDMKDKIALFCDIDTKAVIECEDADNLYSIPLELQKQGLDKLVCEHMKLACKEAEMSE WKELVNKVSNLSQTITIGLVGKYVELPDAYISVVESLRHAGYAFDTDVKVKWINAEEV TENNIAELTSGTDGIIVPGGFGDRGVEGKIVATKYARENNIPFLGICLGMQVASIEYA RNVLGLKGAHSAEIDPSTQYPIIDLLPEQKDVEDLGGTLRLGLYPCKLEEGTKAFEVY QDEVVYERHRHRYEFNNEFRQQMEEQGFVFSGTSPDGRLVEIIELKDHPWFVASQFHP EFKSRPTRPQPLFKGFIGASVEAANQK*" /label="pyrG CDS" gene complement(3205084..3206691) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /label="pyrG gene" downshifts complement(3205097) /Source="Nicolas_upshifts" /id="D1921" /incds=0 /nref=222 /ntot=259 /MaxReadThrough="2.2929" /MaxDrop="8.17874" /score="18.9699606" /energy="-12.1" /TU="NA" /idTUdmin="U2927" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3206692..3206879) /Source="Nicolas_S_feature" /locus_tag="new_3812301_3812488_c" /HighExp="LBGexp, Lbexp, dia0, G150, G135, G180, Paraq, Oxctl, dia15, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1441" promotor_-10 complement(3206867..3206886) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3206879) /Source="Nicolas_upshifts" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3206901..3206908) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3206933..3207454) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase (delta subunit) and transcriptional repressor" /protein_id="NP_391597.1" /db_xref="EnsemblGenomes-Gn:BSU37160" /db_xref="EnsemblGenomes-Tr:CAB15744" /db_xref="GOA:P12464" /db_xref="InterPro:IPR007759" /db_xref="InterPro:IPR029757" /db_xref="PDB:2KRC" /db_xref="PDB:2M4K" /db_xref="PDB:4NC7" /db_xref="PDB:4NC8" /db_xref="SubtiList:BG10409" /db_xref="UniProtKB/Swiss-Prot:P12464" /translation="MGIKQYSQEELKEMALVEIAHELFEEHKKPVPFQELLNEIASLL GVKKEELGDRIAQFYTDLNIDGRFLALSDQTWGLRSWYPYDQLDEETQPTVKAKKKKA KKAVEEDLDLDEFEEIDEDDLDLDEVEEELDLEADDFDEEDLDEDDDDLEIEEDIIDE DDEDYDDEEEEIK*" /label="rpoE CDS" gene complement(3206933..3207454) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /label="rpoE gene" downshifts complement(3206989) /Source="Nicolas_upshifts" /id="D1922" /incds=0 /nref=7 /ntot=182 /MaxReadThrough="6.49215" /MaxDrop="3.2129" /score="19.8764263" /energy="-19.4" /TU="U2928,U2929" /idTUdmin="U2927" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" S_feature complement(3207455..3207557) /Source="Nicolas_S_feature" /locus_tag="new_3813064_3813166_c" /HighExp="H2O2, Paraq, Oxctl, LBGexp, G180, dia15, dia0, Lbexp, BMM, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1442" promotor_-10 complement(3207538..3207557) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3207557) /Source="Nicolas_upshifts" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3207559..3207636) /Source="Nicolas_S_feature" /locus_tag="new_3813168_3813245_c" /HighExp="T0.30H, S8, S7, S6, S4, S3, S5, Sw, BC, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1443" promotor_-35 complement(3207573..3207576) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3207637..3208776) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase" /protein_id="NP_391598.1" /db_xref="EnsemblGenomes-Gn:BSU37170" /db_xref="EnsemblGenomes-Tr:CAB15745" /db_xref="GOA:P45867" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG11239" /db_xref="UniProtKB/Swiss-Prot:P45867" /translation="MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFRE MANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFG TEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNG GVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCV VPASKRLGEEGEGFKIAMKTLDGGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIA EQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEA VQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD*" /label="acdA CDS" gene complement(3207637..3208776) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /label="acdA gene" CDS complement(3208773..3210890) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative iron-sulphur-binding reductase" /protein_id="NP_391599.1" /db_xref="EnsemblGenomes-Gn:BSU37180" /db_xref="EnsemblGenomes-Tr:CAB15746" /db_xref="GOA:P45866" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11311" /db_xref="UniProtKB/Swiss-Prot:P45866" /translation="MSGFLIANALLFLIVTAYAVYLFVYLVKTRLAYIKLGQKEQFDQ RFKERLHAIWVNVFGQKKLLKDKKSGIIHVMFFYGFILVQFGAIDFIIKGLAPGRNLS LGPVYPAFTFFQEIVTFLILIAVGWAFYRRYIEKLVRLKRGFKAGLVLIFIGGLMLTV LLGNGMNLIWHEHGLSWSEPIASGIAFMLSGVGKTGAAVIFYIAWWIHLLFLLSFLVY VPQSKHAHLIAGPANVFFNRMESAGKLEKIDFTDETKESYGAGKIEDFRQSQLLDLYA CVECGRCTNMCPATGTGKMLSPMDLILRLRDHLTEKGAAVTSRSPWVPAAAFRHTRGN QLAAASAGSGSQEAAAALDYNPSLIGDVITEEEIWACTTCRNCEDQCPVMNEHVDKII DLRRYLVLTEGKMDSDAQRAMTSIERQGNPWGLNRKERENWRDEAPDAEIPTVKEMKK EGKEFEYLFWVGSMGSYDNRSQKIAISFAKLLNHAGVSFAILGNKEKNSGDTPRRLGN EFLFQELAEKNISEFEKNDVKKIVTIDPHAYNLFKNEYPDFGFEGEVYHHTEVLAELV KNGKLRPQHPLHETITFHDSCYLGRYNEVYDPPREILKAIPGVQLVEMERSRETGMCC GAGGGLMWMEEETGNRINVARTEQALAVNPSVISSGCPYCLTMLGDGTKAKEAEDQVK TYDVVELLAQSVLGADLKMGEKQ*" /label="fadF CDS" gene complement(3208773..3210890) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /label="fadF gene" S_feature complement(3210891..3210949) /Source="Nicolas_S_feature" /locus_tag="new_3816500_3816558_c" /HighExp="T0.30H, S6, BC, S8, S7, Sw, S5, S4, Lbstat, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1444" promotor_-10 complement(3210950..3210969) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3210963) /Source="Nicolas_upshifts" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3210983..3210990) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3210989..3210995 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3211009..3211020 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3211014 /Source="Nicolas_upshifts" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="upshifts" CDS 3211045..3212241 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14973018, 16514141, 18820022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16514141, 18820022; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase (phospholipase D family)" /protein_id="NP_391600.1" /db_xref="EnsemblGenomes-Gn:BSU37190" /db_xref="EnsemblGenomes-Tr:CAB15747" /db_xref="GOA:P45865" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="SubtiList:BG11310" /db_xref="UniProtKB/Swiss-Prot:P45865" /translation="MKVFIVIMIIVVIFFALILLDIFMGRAGYRKKAYEPVFSKKKSD IELIHCGADLVERMMNDIRQAASSVHMMFFIMKNDEVSHNMYTLLKTKAQAGVSVYLL LDWAGCRAIKKTALQTMKNAGVHVHVMNRPRFPFFFFHMQKRNHRKITVIDGKIGYIG GFNIAEEYLGKKAKFGNWEDYHLRMIGEGVHDLQTLFASDLKRNTGIELGSDVWPKLQ QGTISHKIYATDGYSLENIYLANIAQAKNRLTVCTPYYIPSKPLQEALINARKNGVSV RIIVPMKSDHPLVREAAFTYYSELLDAGCLIYRYYQGFYHVKALIIDDHLSIIGTANF DKRSLFLNEEVNVEIDDEAFTSEVYATIEEDMKKSELLTMEDFSKRTFRQRPAEWLGR ALSYFL*" /label="clsB CDS" gene 3211045..3212241 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /label="clsB gene" S_feature complement(3211237..3212115) /Source="Nicolas_S_feature" /locus_tag="new_3816846_3817724_c" /HighExp="S4, S5, S3, S6, S7, S8, BT, B36, LoTm, B60" /AntisenseName="clsB" /AntisenseCor="0.84883232203587" /AntisenseRegPval="-75.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1445" promotor_-10 complement(3212105..3212123) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3212116) /Source="Nicolas_upshifts" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3212139..3212144) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3212254..3213216 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /EC_number="3.-.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8614629, 22961846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8614629, 22961846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UV DNA damage repair endonuclease" /protein_id="NP_391601.1" /db_xref="EnsemblGenomes-Gn:BSU37200" /db_xref="EnsemblGenomes-Tr:CAB15748" /db_xref="GOA:P45864" /db_xref="InterPro:IPR004601" /db_xref="InterPro:IPR023520" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11309" /db_xref="UniProtKB/Swiss-Prot:P45864" /translation="MIFRFGFVSNAMSLWDASPAKTLTFARYSKLSKTERKEALLTVT KANLRNTMRTLHYIIGHGIPLYRFSSSIVPLATHPDVMWDFVTPFQKEFREIGELVKT HQLRTSFHPNQFTLFTSPKESVTKNAVTDMAYHYRMLEAMGIADRSVINIHIGGAYGN KDTATAQFHQNIKQLPQEIKERMTLENDDKTYTTEETLQVCEQEDVPFVFDFHHFYAN PDDHADLNVALPRMIKTWERIGLQPKVHLSSPKSEQAIRSHADYVDANFLLPLLERFR QWGTNIDFMIEAKQKDKALLRLMDELSSIRGVKRIGGGALQWKS*" /label="uvsE CDS" gene 3212254..3213216 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /label="uvsE gene" promotor_-35 3213230..3213236 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3213251..3213269 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3213251 /Source="Nicolas_upshifts" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="upshifts" CDS 3213297..3213569 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391602.1" /db_xref="EnsemblGenomes-Gn:BSU37210" /db_xref="EnsemblGenomes-Tr:CAB15749" /db_xref="InterPro:IPR035895" /db_xref="SubtiList:BG11308" /db_xref="UniProtKB/Swiss-Prot:P45863" /translation="MKNIKSLKVAAQAFTLRNLIHLYKMCHSGSHEVYIYSKKTMCKI KSLIELETFRMAHNEKEYLIVVEGTKASQLIEKFQNLIEPAEREAL*" /label="ywjC CDS" gene 3213297..3213569 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /label="ywjC gene" downshifts complement(3213303) /Source="Nicolas_upshifts" /id="D1923" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="1.03516" /MaxDrop="5.08765" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 3213559 /Source="Nicolas_upshifts" /id="D1924" /incds=0 /nref=54 /ntot=128 /MaxReadThrough="4.49396" /MaxDrop="7.49636" /score="14.0189582" /energy="-10" /TU="U2932" /idTUdmin="U2930" /TUdmin=178 /isTUend="FALSE" /label="downshifts" S_feature 3213604..3214010 /Source="Nicolas_S_feature" /locus_tag="new_3819213_3819619" /HighExp="Etha, C30, Sw, Gly, C90, M/G, BC, Salt, Fru, G135" /AntisenseName="ywjB" /AntisenseCor="0.2646821361217" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1446" CDS complement(3213611..3214135) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391603.1" /db_xref="EnsemblGenomes-Gn:BSU37220" /db_xref="EnsemblGenomes-Tr:CAB15750" /db_xref="GOA:P45862" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG11307" /db_xref="UniProtKB/Swiss-Prot:P45862" /translation="MERKTVLYIAVSLDGMIAKEDGSIDWLDEFEGEGDNGYSDFYQT VDTVILGRSTYEHVKVLTPVFPYQDKTCYVFTGSPDSYQDEHVTFINEGARAFTARLK QEKGSNIWIAGGAELVNDFMKEDAIDEFIITVIPVVLGSGIPLFHELTNETKLRLKGT KQFGQAVQLHYVRA*" /label="ywjB CDS" gene complement(3213611..3214135) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /label="ywjB gene" downshifts complement(3213633) /Source="Nicolas_upshifts" /id="D1925" /incds=0 /nref=194 /ntot=239 /MaxReadThrough="1.38978" /MaxDrop="6.19859" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3214145..3215872) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12119303, 12354229, 25652542; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC lipid transporter (ATP-binding protein)" /protein_id="NP_391604.1" /db_xref="EnsemblGenomes-Gn:BSU37230" /db_xref="EnsemblGenomes-Tr:CAB15751" /db_xref="GOA:P45861" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11306" /db_xref="UniProtKB/Swiss-Prot:P45861" /translation="MLRQFFSYYKPYKTLFFLDFFSAIAGGLMELSFPLIVNYFIDTL LPGRDWGLIIATSIGLFAVYALSSALQYIVTYWGHMLGINIETDMRKSLFDHLQKLSF KFYDNNKTGTLMSKLTNDLMYIGEVAHHGPEDLFIAVMTILGAFGVMLFINWQLALLT FIIMPIVIWLALYFNKKMTKAFTTLNKDIGDFSARVENNIGGIRLVQAFGNEAFEKER FAVNNQRFRVTKLSSYKIMAKNGSISYMLTRFVTLFVLLCGTWFVIRGSLSYGEFVAF VLLTNVLFRPIDKINAIIEMYPRGIAGFKSYMELMETEPDIQDSPDSKDVSGLKGNIR YKHVSFGYDDHHNVLNDINLSIQAGETVAFVGPSGAGKSTLCSLLPRFYEASEGDITI DGISIKDMTLSSLRGQIGVVQQDVFLFSGTLRENIAYGRLGASEEDIWQAVKQAHLEE LVHNMPDGLDTMIGERGVKLSGGQKQRLSIARMFLKNPSILILDEATSALDTETEAAI QKALQELSEGRTTLVIAHRLATIKDADRIVVVTNNGIEEQGRHQDLIEAGGLYSRLHQ AQFGQMVHR*" /label="ywjA CDS" gene complement(3214145..3215872) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /label="ywjA gene" promotor_-10 complement(3215906..3215925) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3215920) /Source="Nicolas_upshifts" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3215939..3215945) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3215961..3217463) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /EC_number="2.7.8.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14973018, 15743965, 16514141, 26025016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase" /protein_id="NP_391605.1" /db_xref="EnsemblGenomes-Gn:BSU37240" /db_xref="EnsemblGenomes-Tr:CAB15752" /db_xref="GOA:P45860" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG11305" /db_xref="UniProtKB/Swiss-Prot:P45860" /translation="MLKRRLEFFFLYMMLIGAYVIWFFPVSRLEFYGGLLCYISIILF SIYSLILENRTSQHTLLWIHILVFFPIVGYVFYLFSGQLYVKGKLFKTKRMYNREKLR KLFDKEETPEVTGLKDNQERFFTYSIRAAHMNINTKSNIKVLKNGEETFPDIFKAMRK AESYIHIEYYMFKSDMLGRGMMDIMMEKARQGVEVRFLYDAAGSMKLARRDIMRMKQA GVDIVPFSPLKYGFFNQKLNFRNHRKIVIIDGKTGFVGGLNVGKEYISRDPYIGFWRD THLRLEGEIVQTLHAIFMLDWEYVSNEVLIDQEEYNTPVPVEGGGIYQIVATGPDMKE SMSDLYYEMISSAQKSIWIATPYFVPNESIRTALKAAATKGVEVRVMVPEKNDSFLTQ YASRSYFPELLLEGIEVYSYQKGFMHQKVMIIDGDLASVGTANMDMRSFQLNFEVNVF FTDAEAIRTLEAHFEEDMQESEKLSPVGFYKRGVADRTKESFARLFSGVL*" /label="clsC CDS" gene complement(3215961..3217463) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /label="clsC gene" promotor_-10 complement(3217487..3217505) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3217505) /Source="Nicolas_upshifts" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3217520..3217526) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3217550..3217922) /Source="Nicolas_S_feature" /locus_tag="new_3823159_3823531_c" /HighExp="Lbtran, M40t45, nit, LBGtran, LBGstat, S0, ferm, M0t45, Lbstat, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30294500000000002" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S1447" downshifts complement(3217593) /Source="Nicolas_upshifts" /id="D1926" /incds=0 /nref=4 /ntot=19 /MaxReadThrough="2.94229" /MaxDrop="4.09744" /score="13.5274489" /energy="-11.4" /TU="NA" /idTUdmin="U2935" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3217949..3218620) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (gamma subunit)" /protein_id="NP_391606.1" /db_xref="EnsemblGenomes-Gn:BSU37250" /db_xref="EnsemblGenomes-Tr:CAB15753" /db_xref="GOA:P42177" /db_xref="InterPro:IPR003816" /db_xref="InterPro:IPR023234" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11084" /db_xref="UniProtKB/Swiss-Prot:P42177" /translation="MSGQILWGIMPYIVLTIFIGGHIYRYQHDQFGWTAKSSELLEKK KLAAGSTLFHWGLLCVVGGHVMGILIPEGVYASLGISEHMYHKMAIGAGLPAGIAACT GLVILTYRRLFDKRIRKTSSPSDILTLLLLLFMMLSGVAATFLNIDSKGFDYRTTVGP WFREIVLFRPDASLMESVPLWFKFHIVIGYVVFILWPFTRLVHVFSLPLKYLTRSYVV YRKRS*" /label="narI CDS" gene complement(3217949..3218620) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /label="narI gene" downshifts complement(3217967) /Source="Nicolas_upshifts" /id="D1927" /incds=0 /nref=4 /ntot=13 /MaxReadThrough="6.70789" /MaxDrop="4.50566" /score="27.8375931" /energy="-11.7" /TU="U2935" /idTUdmin="U2935" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(3218617..3219171) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase molybdenum cofactor assembly chaperone NarJ" /protein_id="NP_391607.1" /db_xref="EnsemblGenomes-Gn:BSU37260" /db_xref="EnsemblGenomes-Tr:CAB15754" /db_xref="GOA:P42178" /db_xref="InterPro:IPR003765" /db_xref="InterPro:IPR020945" /db_xref="InterPro:IPR036411" /db_xref="SubtiList:BG11083" /db_xref="UniProtKB/Swiss-Prot:P42178" /translation="MNTTDRQITFSALSCLLSYPDEEWRAELPDWKALIQEIGNRQIR EKLLHFFETSASYSPEALIEHYVYTFDFGKKTNMYVTYFNSGEQRERGIELLHLKNTY EQSGFLPTEKELPDYLPLMLEFAAAAEIEAARSVFEKYLSNVRELASRLEKNDSIYAE LLHVLLAALENIGVRESVEGAVQA*" /label="narJ CDS" gene complement(3218617..3219171) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /label="narJ gene" CDS complement(3219197..3220660) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (beta subunit)" /protein_id="NP_391608.1" /db_xref="EnsemblGenomes-Gn:BSU37270" /db_xref="EnsemblGenomes-Tr:CAB15755" /db_xref="GOA:P42176" /db_xref="InterPro:IPR006547" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR029263" /db_xref="SubtiList:BG11082" /db_xref="UniProtKB/Swiss-Prot:P42176" /translation="MKIKAQIGMVMNLDKCIGCHTCSVTCKNTWTNRSGAEYMYFNNV ETKPGIGYPKQWEDQDKYKGGWTLKKGKLELKSGSKTNRLAGLFYNPNQPSIDDYYEP WNYDYETLTNSPQKKHQPVARPKSSLTGDFMNIEWGPNWEDDLAGGHITGLEDPNVQK MEESIKTEFDDVFMMYLPRICEHCINPACVSSCPSGAMYKREEDGIVLVDQNACRSWR YCVSSCPYKKVYFNWQTNKAEKCTLCFPRLEAGLPTICSETCVGRIRYLGVMLYDADK VEEAASVENEKDLYHSQLDVFLDPNDPEVAKLAKEQGIPAEWIEAAQQSPIYKMIIDW KIALPLHPEYRTLPMVWYIPPLSPIMNLFEGKGSRQTAEDIFPAIDQMRIPIDYLAQL LTAGDTDHIRSTLKKMSVMRQYMRAVQTNKSIDPELISSVGLTEQQIEDMYRLLAIAK YDDRFVIPSSHREEVSDLYAEQGSCGLSFSGGPGSCF*" /label="narH CDS" gene complement(3219197..3220660) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /label="narH gene" CDS complement(3220650..3224336) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /EC_number="1.7.5.1" /EC_number="1.7.99.4" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11289299, 7557333, 7860592, 8846791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (alpha subunit)" /protein_id="NP_391609.2" /db_xref="EnsemblGenomes-Gn:BSU37280" /db_xref="EnsemblGenomes-Tr:CAB15756" /db_xref="GOA:P42175" /db_xref="InterPro:IPR006468" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="InterPro:IPR028189" /db_xref="SubtiList:BG11081" /db_xref="UniProtKB/Swiss-Prot:P42175" /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRW QYDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGAS FSWYIYSPLRVKYPYVRGVLINLWREALQTHQNPLEAWKSIVENPEKAKSYKQARGKG GFVRAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPM LSFYDWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEAR YKGAKVISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEY AKQYTDFPFLVTLSKENGVYTAGRFLHAKDIGRKTKHDQWKPAVWDEQTSSFAIPQGT MGSRWDGQQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLP IKKMNLNGEETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKE AVVKIAREFAQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGW AHYVGQEKLRPAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPI AASSRYKHHADYNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQL QEKKLKFAIEDPDNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDS IRPEEIKWREQAPEGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFI HPFAPAISAPWESKSDWDIFKALSKAVSDLAEEVDMEPVKEVVATPLLHDTMQELAQP FGKINDWSKGECEAIPGKTMPNIQVVERDYKHIFHKMTALGPNVALKPSGTKGMSWSI ADEYESLKQRLGEITSDSVAKGCPNISEAKQAAEAILTLSSTSNGKVAVKAWESLENI TNLKLKDLAEEREEECFTFEQITAQPKTVITSPAFTGSEKGGRRYSPFTTNVEKLIPW RTLTGRQSYYVDHELMMEFGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKW SVHSMYFDSLPMLTLFRGGPTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHR IPKGMAFMHHAQDRHINVPGTKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYY GPTGNQRDLNVVIRKLKEVDWLED*" /label="narG CDS" gene complement(3220650..3224336) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /label="narG gene" misc_feature complement(3224367..3224386) /Source="Nicolas_upshift_promotors" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3224391) /Source="Nicolas_upshifts" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3224393..3224522) /Source="Nicolas_S_feature" /locus_tag="new_3830002_3830131_c" /HighExp="Lbtran, M40t45, LBGtran, ferm, M0t45, nit, S0, Lbstat, LBGstat, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1448" CDS complement(3224532..3225008) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 11698370, 16428414, 22178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 11698370, 16428414, 22178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_391610.1" /db_xref="EnsemblGenomes-Gn:BSU37290" /db_xref="EnsemblGenomes-Tr:CAB15757" /db_xref="GOA:P46910" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018490" /db_xref="SubtiList:BG11345" /db_xref="UniProtKB/Swiss-Prot:P46910" /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSF LHSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSD ILILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS*" /label="arfM CDS" gene complement(3224532..3225008) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /label="arfM gene" downshifts complement(3224567) /Source="Nicolas_upshifts" /id="D1928" /incds=0 /nref=10 /ntot=39 /MaxReadThrough="5.03469" /MaxDrop="3.83412" /score="30.7487171" /energy="-10.5" /TU="U2936" /idTUdmin="U2936" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3225031..3225050) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-10" upshifts complement(3225043) /Source="Nicolas_upshifts" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="upshifts" promotor_-35 complement(3225065..3225068) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-35" upshifts 3225115 /Source="Nicolas_upshifts" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3225118..3225137 /Source="Nicolas_upshift_promotors" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3225152..3225871 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16428414, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391611.1" /db_xref="EnsemblGenomes-Gn:BSU37300" /db_xref="EnsemblGenomes-Tr:CAB15758" /db_xref="GOA:P46909" /db_xref="InterPro:IPR025576" /db_xref="SubtiList:BG11344" /db_xref="UniProtKB/Swiss-Prot:P46909" /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYL AVYPVTLALKKKQSKPYQKWMCYYGFPTCCFLMISVFHKPPLIWVGVSLLPLFLIHMY FARRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVK SVIRERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTI GILEIVNACFFLAVMCLFITR*" /label="ywiC CDS" gene 3225152..3225871 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /label="ywiC gene" downshifts 3225855 /Source="Nicolas_upshifts" /id="D1929" /incds=0 /nref=14 /ntot=34 /MaxReadThrough="2.00369" /MaxDrop="5.63285" /score="-3.54009378" /energy="-5.8" /TU="NA" /idTUdmin="U2937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3225903..3226619) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 16796679, 21068385, 23046954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 16796679, 21068385, 23046954; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of anaerobic metabolism (FNR/CAP family)" /protein_id="NP_391612.1" /db_xref="EnsemblGenomes-Gn:BSU37310" /db_xref="EnsemblGenomes-Tr:CAB15759" /db_xref="GOA:P46908" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR012318" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018335" /db_xref="InterPro:IPR018490" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11343" /db_xref="UniProtKB/Swiss-Prot:P46908" /translation="MNFLSVRPSDSDLISSDLYELLESISTKRKMEKHTYLFREGMDA EELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEV LVINKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSN SYGVERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKR DYLRCEIECENCPLEICNID*" /label="fnr CDS" gene complement(3225903..3226619) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /label="fnr gene" downshifts complement(3225905) /Source="Nicolas_upshifts" /id="D1930" /incds=0 /nref=116 /ntot=238 /MaxReadThrough="3.06242" /MaxDrop="8.21489" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-84" /isTUend="FALSE" /label="downshifts" downshifts complement(3225975) /Source="Nicolas_upshifts" /id="D1931" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.51297" /MaxDrop="3.71248" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" misc_feature complement(3226645..3226664) /Source="Nicolas_upshift_promotors" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3226657) /Source="Nicolas_upshifts" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3226718..3227905) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 15849754, 16796679, 16850406, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 15849754, 16796679, 16850406, 26786044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite extrusion permease" /protein_id="NP_391613.2" /db_xref="EnsemblGenomes-Gn:BSU37320" /db_xref="EnsemblGenomes-Tr:CAB15760" /db_xref="GOA:P46907" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11342" /db_xref="UniProtKB/Swiss-Prot:P46907" /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEI SLVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGG FFLGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKS TVQMYLILLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAF VAFTIYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFA GLTLSGIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAM GGLGGFFPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQ SIN*" /label="narK CDS" gene complement(3226718..3227905) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /label="narK gene" misc_feature complement(3227935..3227954) /Source="Nicolas_upshift_promotors" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3227953) /Source="Nicolas_upshifts" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3228041..3229711) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /EC_number="6.1.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8289305, 9862121" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8289305, 9862121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginyl-tRNA synthetase" /protein_id="NP_391614.1" /db_xref="EnsemblGenomes-Gn:BSU37330" /db_xref="EnsemblGenomes-Tr:CAB15761" /db_xref="GOA:P46906" /db_xref="InterPro:IPR001278" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR005148" /db_xref="InterPro:IPR008909" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR035684" /db_xref="InterPro:IPR036695" /db_xref="SubtiList:BG11341" /db_xref="UniProtKB/Swiss-Prot:P46906" /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHG DYSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTK LIPSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAG YDVSREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEY GDRFVNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKAL EALREKGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDK LINVWGADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVT MRDLIEEVGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQ GEEQGLKPAADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASA LHSFYNAEKVIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM*" /label="argS CDS" gene complement(3228041..3229711) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /label="argS gene" downshifts complement(3228043) /Source="Nicolas_upshifts" /id="D1932" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="1.71727" /MaxDrop="6.56513" /score="23.3947976" /energy="-12.5" /TU="NA" /idTUdmin="U2941" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3229708..3230136) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_391615.1" /db_xref="EnsemblGenomes-Gn:BSU37340" /db_xref="EnsemblGenomes-Tr:CAB15762" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015231" /db_xref="PDB:1R0U" /db_xref="SubtiList:BG14161" /db_xref="UniProtKB/Swiss-Prot:O07624" /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYY EEHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKS IQSDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA*" /label="ywiB CDS" gene complement(3229708..3230136) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /label="ywiB gene" misc_feature 3230204..3230218 /Source="Nicolas_upshift_promotors" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3230204..3230223) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3230211 /Source="Nicolas_upshifts" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3230220) /Source="Nicolas_upshifts" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3230240..3230243) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3230275..3230294) /Source="Nicolas_upshift_promotors" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3230287) /Source="Nicolas_upshifts" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="upshifts" SCAR join(3230316,3230323) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs09" N_region 3230317..3230322 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs09" S_feature <3230323..3232801 /Source="Nicolas_S_feature" /locus_tag="new_3842996_3845478" /HighExp="Lbstat, nit, ferm, BI, M0t90, S2, M40t90, BT, M0t45, GM 150" /AntisenseName="ywhL" /AntisenseCor="7.7827453562424306E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1450" CDS complement(3230324..3231700) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12073041" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391624.1" /db_xref="EnsemblGenomes-Gn:BSU37440" /db_xref="EnsemblGenomes-Tr:CAB15771" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12464" /db_xref="UniProtKB/Swiss-Prot:P71004" /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDFPEGFKVDTAEA SAAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGD GAVSVIHTEEIDQVVYYAAQSGRCPDFSQITVEDLLIVPPFYGSPLTVAGTLVLPPSP DPQSYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLV SVIDNKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPG ALDFALDPNGQYVYTANGSSWSVDKYDVNTGQLVESIIDTFEFPSLITTPYAGNFAYV LNGELWPKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNL YVVNTARQRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVG AGPSAIAM*" /label="ywhL CDS" gene complement(3230324..3231700) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /label="ywhL gene" CDS complement(3231739..3233094) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12073041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073041; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DNA helicase PcrA" /protein_id="NP_391625.1" /db_xref="EnsemblGenomes-Gn:BSU37450" /db_xref="EnsemblGenomes-Tr:CAB15772" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12463" /db_xref="UniProtKB/Swiss-Prot:P71003" /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFV VDPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRN QYGQGDGAVSVIHNAEIDQVVYYSDESDDCPDISDITIENLVVVPPFYGSPLSVTGTI VLVPEPEPVYAFTANPNDQSVSVIDTNTDTVVTTIALPYNPAGIEITPDKSAVFVLHP NNNVISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAVYVIGIDTLTVDRS IPVEGYDVAIDPNGLFAYVLNFGIVQKVDLTTGEVTGTIERELIVSTIETNWPERYAY VLEQEFFFNYLTVIDLNTFTISSTQELEYEGEYRMFTSGAEVYLYDGFTGNLYSVSPN GAGVIGNVPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAIT I*" /label="ywhK CDS" gene complement(3231739..3233094) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /label="ywhK gene" promotor_-10 complement(3233130..3233149) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3233148) /Source="Nicolas_upshifts" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3233162..3233171) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3233274..3233293 /Source="Nicolas_upshift_promotors" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3233275 /Source="Nicolas_upshifts" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3233320) /Source="Nicolas_upshifts" /id="D1937" /incds=0 /nref=7 /ntot=59 /MaxReadThrough="2.35357" /MaxDrop="4.85842" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=1867 /isTUend="FALSE" /label="downshifts" CDS 3233324..3234469 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase anti-activator of ComA" /protein_id="NP_391626.1" /db_xref="EnsemblGenomes-Gn:BSU37460" /db_xref="EnsemblGenomes-Tr:CAB15773" /db_xref="GOA:P71002" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3ULQ" /db_xref="PDB:4I9C" /db_xref="PDB:4I9E" /db_xref="SubtiList:BG11968" /db_xref="UniProtKB/Swiss-Prot:P71002" /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQME EDQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYY FNFFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFS MDYARQAYEIYKEHEAYNIRLLQCHSLFATNFLDLKQYEDAISHFQKAYSMAEAEKQP QLMGRTLYNIGLCKNSQSQYEDAIPYFKRAIAVFEESNILPSLPQAYFLITQIHYKLG KIDKAHEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYA DLEDFAIDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV*" /label="rapF CDS" gene 3233324..3234469 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /label="rapF gene" promotor_-35 3234328..3234332 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3234349..3234368 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3234356 /Source="Nicolas_upshifts" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3234439) /Source="Nicolas_upshifts" /id="D1938" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="1.70728" /MaxDrop="2.74755" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 3234453..3234572 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type f: factor" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapF" /protein_id="NP_391627.1" /db_xref="EnsemblGenomes-Gn:BSU37470" /db_xref="EnsemblGenomes-Tr:CAB15774" /db_xref="GOA:P71001" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11960" /db_xref="UniProtKB/Swiss-Prot:P71001" /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI*" /label="phrF CDS" gene 3234453..3234572 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /label="phrF gene" downshifts 3234557 /Source="Nicolas_upshifts" /id="D1939" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="5.48985" /MaxDrop="6.14096" /score="19.6493244" /energy="-9.9" /TU="U2946" /idTUdmin="U2947" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" S_feature 3234602..3234670 /Source="Nicolas_S_feature" /locus_tag="new_3847279_3847347" /HighExp="S2, S3, S4, S5, S6, S1, BT, S7, S8, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.921" /TUlongSig="NA" /TUlongPSig="NA" /label="S1451" CDS 3234671..3235144 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA editing enzyme" /protein_id="NP_391628.1" /db_xref="EnsemblGenomes-Gn:BSU37480" /db_xref="EnsemblGenomes-Tr:CAB15775" /db_xref="GOA:P71000" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12462" /db_xref="UniProtKB/Swiss-Prot:P71000" /translation="MSLKSVRTHFTQWNRENDVTEFETSSATVEQAAETIGVSLSRIA KSLSFRGEGDQVILIVAAGDAKIDNKKSRQTFGFKARMLSPNEVLEQTGHEIGGVCPF GLAHDPEVYLDVSLKRFQTVFPACGSRNSAIELTPKELSEFSFSKVWIDVCKDWE*" /label="ywhH CDS" gene 3234671..3235144 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /label="ywhH gene" downshifts 3235133 /Source="Nicolas_upshifts" /id="D1940" /incds=0 /nref=30 /ntot=156 /MaxReadThrough="2.85314" /MaxDrop="4.40065" /score="-6.80415499" /energy="-11.3" /TU="NA" /idTUdmin="U2946" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3235176..3236048) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /EC_number="3.5.3.11" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9723923, 10931887, 24678831, 28807600, 28291380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10931887, 24678831, 28807600, 28291380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="agmatinase" /protein_id="NP_391629.1" /db_xref="EnsemblGenomes-Gn:BSU37490" /db_xref="EnsemblGenomes-Tr:CAB15776" /db_xref="GOA:P70999" /db_xref="InterPro:IPR005925" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG12461" /db_xref="UniProtKB/Swiss-Prot:P70999" /translation="MRFDEAYSGKVFIASRPEWEEADAILYGMPMDWTVSYRPGSRFG PSRIREVSIGLEEYSPYLDRDLADLNFFDAGDIPLPFGNPQRSLDMIEEYVDSILEKG KFPMGMGGEHLVSWPVIKAMYKKYPDLAIIHFDAHTDLRVDYEGEPLSHSTPIRKAAE LIGPHNVYSFGIRSGMKEEFEWAKENGMHISKFEVLEPLKEVLPKLAGRPVYVTIDID VLDPAHAPGTGTVDAGGITSKELLASVHEIARSEVNVKGADLVEVAPVYDHSEQTANT ASKIIREMLLGFVK*" /label="speB CDS" gene complement(3235176..3236048) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /label="speB gene" downshifts complement(3235187) /Source="Nicolas_upshifts" /id="D1941" /incds=0 /nref=49 /ntot=171 /MaxReadThrough="2.5482" /MaxDrop="5.46925" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3235253) /Source="Nicolas_upshifts" /id="D1942" /incds=1 /nref=8 /ntot=50 /MaxReadThrough="5.83631" /MaxDrop="3.87062" /score="29.5788849" /energy="-11.3" /TU="U2948" /idTUdmin="U2948" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(3236109..3236939) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /EC_number="2.5.1.16" /function="16.3: Control" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9723923, 26735940, 28546427, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 26735940, 28546427, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermidine synthase; polyamine metabolism" /protein_id="NP_391630.1" /db_xref="EnsemblGenomes-Gn:BSU37500" /db_xref="EnsemblGenomes-Tr:CAB15777" /db_xref="GOA:P70998" /db_xref="InterPro:IPR001045" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030373" /db_xref="InterPro:IPR030374" /db_xref="InterPro:IPR035246" /db_xref="InterPro:IPR037163" /db_xref="PDB:1IY9" /db_xref="SubtiList:BG12460" /db_xref="UniProtKB/Swiss-Prot:P70998" /translation="MSELWYTEKQTKNFGITMKVNKTLHTEQTEFQHLEMVETEEFGN MLFLDGMVMTSEKDEFVYHEMVAHVPLFTHPNPEHVLVVGGGDGGVIREILKHPSVKK ATLVDIDGKVIEYSKKFLPSIAGKLDDPRVDVQVDDGFMHIAKSENQYDVIMVDSTEP VGPAVNLFTKGFYAGIAKALKEDGIFVAQTDNPWFTPELITNVQRDVKEIFPITKLYT ANIPTYPSGLWTFTIGSKKYDPLAVEDSRFFDIETKYYTKDIHKAAFVLPKFVSDLIK *" /label="speE CDS" gene complement(3236109..3236939) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /label="speE gene" S_feature complement(3236940..3237035) /Source="Nicolas_S_feature" /locus_tag="new_3849617_3849712_c" /HighExp="Paraq, G180, Oxctl, H2O2, LBGexp, G150, G135, C30, dia15, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1452" promotor_-10 complement(3237023..3237042) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3237034) /Source="Nicolas_upshifts" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3237055..3237062) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3237080..3237085 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3237101..3237119 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3237103 /Source="Nicolas_upshifts" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="upshifts" CDS 3237141..3239216 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10767540, 11567005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10767540, 11567005; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation specific penicillin-binding protein 2D" /protein_id="NP_391631.2" /db_xref="EnsemblGenomes-Gn:BSU37510" /db_xref="EnsemblGenomes-Tr:CAB15778" /db_xref="GOA:P70997" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG12459" /db_xref="UniProtKB/Swiss-Prot:P70997" /translation="MDAMTNKRLRLTLKTVRAFIFLGAFAALAAAAVFMTVILIAKYQ GAPSVQVPQSTILYASDGSKLGETNYGEKRYWVPLKDMNPTIVKATVAIEDQNFYDHH GFDYKRMAGAALADLKAFAKVQGASTITQQYARNLYLEHDKTWKRKWNEAFYTIRLEQ NYSKDEILEGYLNTIYYGHGAYGIEAASRLYFGKHAKNLTDAEAALLAGIPKGPSGYS PYVNETKAKERQKTIVRMMEKQQMISQKKADELIKEPLSYQPLNKQVSKRKAPYFYDN AMRELEKKLGMTREQIETSGLNVYTTVDKRMQRIAEETITETVNAGSDIQVGFSAIDP RTGNVLALVGGRDYQKSPFDRTTQAKRQPASTIKPLLYYKAIQSGFTPVTLMKSEETE FQIDAKGETYSPSNYNGYYANKPITLLQALALSDNIYAVKTHLFLGTNKLVKTAKEFG ITAHLQALPSLALGTEPVRPIEMVNAYAMLANGGKKIEPTFISRVTDAAGHVLYENPN QHKQVLDEKAAFVTASMMTGMFDIDLNGYTSVTGRTIANRLTRTYAGKSGTTSADSWM IGFNPKLAAGVWTGYDKNSTIDSVEEKSYAKTIWADFMEDALKGEPETAFKPPKGVTG VYIDPETGYSSGPGCAAKHYTYFVKGTEPANVCYGAEPAKQTKDRLPSKEKPASEKKW WDKWLGRHH*" /label="pbpG CDS" gene 3237141..3239216 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /label="pbpG gene" downshifts complement(3239269) /Source="Nicolas_upshifts" /id="D1943" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="1.43573" /MaxDrop="3.61075" /score="-7.59753556" /energy="-10.7" /TU="NA" /idTUdmin="U2951" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(3239393..3239508) /Source="Nicolas_S_feature" /locus_tag="new_3852070_3852185_c" /HighExp="Sw, C90, BI, dia5, dia15, Diami, LBGexp, M0t45, Lbexp, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1453" downshifts complement(3239436) /Source="Nicolas_upshifts" /id="D1944" /incds=0 /nref=198 /ntot=248 /MaxReadThrough="3.25498" /MaxDrop="6.4287" /score="-7.59753556" /energy="-10.7" /TU="U2951,U2952" /idTUdmin="U2952" /TUdmin="-156" /isTUend="FALSE" /label="downshifts" CDS complement(3239509..3240027) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391632.1" /db_xref="EnsemblGenomes-Gn:BSU37520" /db_xref="EnsemblGenomes-Tr:CAB15779" /db_xref="InterPro:IPR014852" /db_xref="SubtiList:BG12458" /db_xref="UniProtKB/Swiss-Prot:P70996" /translation="MEEKKKKSIGFNIIKSDPTDGHGGFGVGALSLDNISPVFVDVEE KEAFVDIGAMHARSTVEKGIKFLPNKEEVPNGKPYWLVWVTIDRKEEGPYYAGVTACE MTVDRSIRRGYKSLPEHVNLMDKSMKRKIIVDKMDDSSKRVLGEFLKKHDQGLWDRSS DELKTSLLPENN*" /label="ywhD CDS" gene complement(3239509..3240027) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /label="ywhD gene" CDS complement(3240041..3240700) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /EC_number="3.4.24.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase; integral membrane protein" /protein_id="NP_391633.1" /db_xref="EnsemblGenomes-Gn:BSU37530" /db_xref="EnsemblGenomes-Tr:CAB15780" /db_xref="GOA:P70995" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG12457" /db_xref="UniProtKB/Swiss-Prot:P70995" /translation="MDRFLYYPLSLMPYLVITLIVSFTMHELAHAYVAYKFGDDTAKK QGRLTLNPIKHLDPFGTILILVAGFGWARPIPVNRRFFKKPRLAGVLVSIAGPVSNLI LAFIGFFLLVLMHAYGMEMLAAFSTGLDQFFSIWIQLNLVLFLFNLLPLPPLDGYRII EDLVPPGVRAKMTQAESYGFIVFLVLFVTPLGSYVLWPMLNAGRDSILKLFSAIFQPL L*" /label="ywhC CDS" gene complement(3240041..3240700) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /label="ywhC gene" promotor_-35 3240723..3240726 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3240736..3240755) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3240741..3240760 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3240744 /Source="Nicolas_upshifts" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3240754) /Source="Nicolas_upshifts" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3240756..3241039) /Source="Nicolas_S_feature" /locus_tag="new_3853433_3853716_c" /HighExp="Diami, dia5, dia15, C90, Etha, Sw, H2O2, G135, M40t45, Lbtran" /AntisenseName="ywhB" /AntisenseCor="0.10541372702249199" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1454" promotor_-35 complement(3240770..3240777) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3240809..3240997 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /EC_number="5.3.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12051677, 14624569, 14730980, 15301547, 17902707" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12051677, 14624569, 14730980, 15301547, 17902707; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxymuconate tautomerase (promiscuous)" /protein_id="NP_391634.1" /db_xref="EnsemblGenomes-Gn:BSU37540" /db_xref="EnsemblGenomes-Tr:CAB15781" /db_xref="GOA:P70994" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="InterPro:IPR018191" /db_xref="PDB:2OP8" /db_xref="PDB:2OPA" /db_xref="SubtiList:BG12456" /db_xref="UniProtKB/Swiss-Prot:P70994" /translation="MPYVTVKMLEGRTDEQKRNLVEKVTEAVKETTGASEEKIVVFIE EMRKDHYAVAGKRLSDME*" /label="hmtB CDS" gene 3240809..3240997 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /label="hmtB gene" downshifts 3240986 /Source="Nicolas_upshifts" /id="D1945" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="1.74275" /MaxDrop="4.93207" /score="4.21502693" /energy="-10.5" /TU="NA" /idTUdmin="U2950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3241040..3241459) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391635.1" /db_xref="EnsemblGenomes-Gn:BSU37550" /db_xref="EnsemblGenomes-Tr:CAB15782" /db_xref="GOA:P70993" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12455" /db_xref="UniProtKB/Swiss-Prot:P70993" /translation="MDHDKLEANLLDHALTKYLKSTKQLDEATVPKHVNNVRGFILRI IYRHGSCTIKDILKEVTLSPSATTTALNHLEQEGFIERSRNNNDRRTVWITLSESGRG AAEQMIENRQQLIDGMFERLTAEEKKTFLAIIAKLAQ*" /label="ywhA CDS" gene complement(3241040..3241459) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /label="ywhA gene" promotor_-10 complement(3241509..3241528) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3241520) /Source="Nicolas_upshifts" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3241543..3241550) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3241579..3243495) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9353933, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9353933, 15831787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_391636.2" /db_xref="EnsemblGenomes-Gn:BSU37560" /db_xref="EnsemblGenomes-Tr:CAB15783" /db_xref="GOA:P18256" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10421" /db_xref="UniProtKB/Swiss-Prot:P18256" /translation="MSKHVHIQLPDGQIQEYPKGITIKEAAGSISSSLQKKAAAGQVN GKLVDLSFKLEEDAELSIVTLDSQEGLQVLRHTTAHVLAQAVKRLYGEVSLGVGPVIL DGFYYDMKLGKSLASGDLEAIEKEMKNIINENLEIKRIEVSYEEAEELFAQKDERLKL EILKDIPRGEDITLYQQGEFVDLCRGPHLPSTGMIKAFKLTRVSGAYWRGDSKNEVLQ RVYGVAFQKKKDLDAHLHMLEEAAKRDHRKLGKQLGLFMFSEEAPGMPFYLPKGQIVR NELERFSRELQTNAGYDEVRTPFMMNQRLWEQSGHWDHYRDNMYFSEVDDTRFAMKPM NCPGHMLIFKNSLYSYRDLPIRMAEFGQVHRHEYSGALNGMLRVRTFCQDDAHIFVRE DQIESEIKEAIRLIDEVYRTFGFEYSVELSTRPEDSLGDDSLWEASERALARVLEELG LSYEINEGDGAFYGPKIDFHIKDALKRSHQCATIQLDFQMPEKFDLTYINELNEKVRP VVIHRAVFGSIDRFFGILIEHYGGAFPVWLAPIQVQIIPVSHVHLDYCRKVQAELKQA GIRAGIDERNEKLGYKIRESQVQKIPYVLVLGDHEEQENAVNVRRFGHQQNEHVPFQT FKDKLVKQVENRGM*" /label="thrZ CDS" gene complement(3241579..3243495) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /label="thrZ gene" promotor_-10 complement(3242773..3242791) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3242778) /Source="Nicolas_upshifts" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3242808..3242812) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3243526) /Source="Nicolas_upshifts" /id="D1946" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.2774" /MaxDrop="3.56231" /score="36.3785359" /energy="-19.5" /TU="U2955" /idTUdmin="U2953" /TUdmin="-968" /isTUend="FALSE" /label="downshifts" misc_RNA complement(3243549..3243770) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /product="T-box" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTB RNA" gene complement(3243549..3243770) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /label="tboTB gene" misc_RNA complement(3243802..3244023) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTA RNA" gene complement(3243802..3244023) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /label="tboTA gene" S_feature complement(3244055..3244317) /Source="Nicolas_S_feature" /locus_tag="new_3856732_3856994_c" /HighExp="S8, S7, S6, S5, BT, Sw, B36, B60, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.61719100000000005" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1455" downshifts 3244066 /Source="Nicolas_upshifts" /id="D1947" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="0.92811" /MaxDrop="3.85666" /score="1.17237511" /energy="-8.3" /TU="NA" /idTUdmin="U2950" /TUdmin=3080 /isTUend="FALSE" /label="downshifts" downshifts complement(3244098) /Source="Nicolas_upshifts" /id="D1948" /incds=0 /nref=52 /ntot=200 /MaxReadThrough="6.68945" /MaxDrop="6.6969" /score="36.414771" /energy="-17.3" /TU="U2955" /idTUdmin="U2953" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3244105..3244260) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514011.1" /translation="MLFTVSREGRTAEIFLTQGKQLTAFEPYQGKQVSDTVMLRYSIF KPIIMCN*" /label="hypothetical protein CDS" gene complement(3244105..3244260) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /label="gene" promotor_-35 3244267..3244270 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3244279..3244292 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3244286 /Source="Nicolas_upshifts" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3244294..3244313) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3244317) /Source="Nicolas_upshifts" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3244327..3244333) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3244340..3245740) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11104814, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11104814, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="toxic compound efflux transporter (may export homoserine)" /protein_id="NP_391637.1" /db_xref="EnsemblGenomes-Gn:BSU37570" /db_xref="EnsemblGenomes-Tr:CAB15784" /db_xref="GOA:Q00538" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10420" /db_xref="UniProtKB/Swiss-Prot:Q00538" /translation="MKNSGSIQESTSSTGISVLIVLALGFLMATLDVTVVNVAMADMK NTLSMSLSGVTWVVDGYILTFASLLLAGGALADRFGSKTIYILGLAVFVMASCLCAAS INGQMLIAGRLIQGIGAALFMPSSLSLLAASYLDERARARMFGLWAALVSAASALGPF IGGVLVQLAGWQSIFLINVPIGAAALISAYRILSRVPGKSSRVNIIGHLLGMMALGFL SYALIQGPSAGWRSPVILVAFTAAVLAFVLFLLREISAKTPILPASLYKNGRFSAAQF IGFLLNFALFGGMFMLSLFLQEAGGASSFMAGVELLPMMAVFVIGNLLFARLANRFEA GQLMFVSMAVSCIIALLLFVLISPDFPYWQLAVLMSVMNLCTGITVPAMTTVIMQAAG QRHTNIAGAALNANRQIGALVGVAITGVIIHLSATWYAGAGFAFLMMGAAYSLAALLV WLFLAAHNGTAASEKM*" /label="mmr CDS" gene complement(3244340..3245740) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /label="mmr gene" CDS complement(3245740..3246210) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885456; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391638.1" /db_xref="EnsemblGenomes-Gn:BSU37580" /db_xref="EnsemblGenomes-Tr:CAB15785" /db_xref="GOA:P71047" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12454" /db_xref="UniProtKB/Swiss-Prot:P71047" /translation="MKMKSGMEQAVSVLLLLSRLPVQASLTSEAISQRLRVSPSYLKK LMRTLVQAGLAESLPGTKGGFTLTKPLADITLYDVYQAVEGRGSMYQGKGLLQSVFEG ESHCVLETVMAEIEDKWSNLMREESLQHVMDRVGELYDLEKIDDWVIKQVKGQL*" /label="ywgB CDS" gene complement(3245740..3246210) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /label="ywgB gene" downshifts complement(3246166) /Source="Nicolas_upshifts" /id="D1949" /incds=0 /nref=11 /ntot=145 /MaxReadThrough="2.78131" /MaxDrop="4.29115" /score="17.3758052" /energy="-11.2" /TU="NA" /idTUdmin="U2956" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3246322..3246822) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391639.1" /db_xref="EnsemblGenomes-Gn:BSU37590" /db_xref="EnsemblGenomes-Tr:CAB15786" /db_xref="SubtiList:BG12453" /db_xref="UniProtKB/Swiss-Prot:P71046" /translation="MLKEHAKLMKVFSDSGEIIGRKKLQKMIYIAKKMQFPFYEKYDF HFYGPYSEELTLQIEELCNLGFLHEVKEKKGGYFQYRYSLTETGSAFLDHADLDMPDM KGYIDSVNSRSSRFLELVSTILYFDGLEDEEKKEKVFTIKSKQKYTNEEYDEALQYIE ELKQIC*" /label="ywgA CDS" gene complement(3246322..3246822) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /label="ywgA gene" downshifts complement(3246325) /Source="Nicolas_upshifts" /id="D1950" /incds=0 /nref=9 /ntot=105 /MaxReadThrough="4.00805" /MaxDrop="6.12059" /score="17.3758052" /energy="-11.2" /TU="U2956,U2957" /idTUdmin="U2957" /TUdmin="-137" /isTUend="FALSE" /label="downshifts" CDS complement(3246858..3248159) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent nucleotide (pyro)phosphohydrolase" /protein_id="NP_391640.1" /db_xref="EnsemblGenomes-Gn:BSU37600" /db_xref="EnsemblGenomes-Tr:CAB15787" /db_xref="GOA:P39651" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG10639" /db_xref="UniProtKB/Swiss-Prot:P39651" /translation="MAYPNGKLSEEKVFKDPVHRYVHVRDKLIWDLIGTREFQRLRRI KQLGTTYLTFHGAEHSRFNHSLGVYEIVRRMVDDVFKGRPEWDDSERELCLAAALLHD LGHGPFSHSFEKVFHLDHEDFTRGIILGDTEVNQVLRKVSPGFPQDVAEVIAKTYKNK QVVSLISSQIDADRMDYLQRDAYYTGVSYGHFDMERILRVMRPREDQIVIKESGMHAV EDYIMSRYQMYWQVYFHPVTRSAEVILTKILHRAKQLHDEGYVFTHAPVHFYSIFEGK LTLEDYVKLDESIILYYFQAWEDEEDAILSDLCRRFINRQLFQYVEFNPNEEMSAYFE LTSLFKEAGIDPSYYLVVDSSSDLPYDFYRPGEEEERLPIHLLTQNGQIKELSRQSAI VESISGKRRTDHKLYYPKDLICDGTKHPEAKMKIRQLLGLT*" /label="ywfO CDS" gene complement(3246858..3248159) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /label="ywfO gene" promotor_-10 complement(3248183..3248202) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3248197) /Source="Nicolas_upshifts" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3248199..3248320) /Source="Nicolas_S_feature" /locus_tag="new_3860876_3860997_c" /HighExp="G180, Paraq, Oxctl, G135, H2O2, G150, C30, LBGstat, LBGexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1456" promotor_-35 complement(3248218..3248220) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3248321..3248545) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391641.1" /db_xref="EnsemblGenomes-Gn:BSU37610" /db_xref="EnsemblGenomes-Tr:CAB15788" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR020880" /db_xref="SubtiList:BG14164" /db_xref="UniProtKB/Swiss-Prot:O32280" /translation="MANEFRVCDDCQATNIKTLLPRLKEVDPDAKVEVGCQSYCGPGR KKSFAFVNNRPLSAPTEDELIDKVKKKIKK*" /label="ywzC CDS" gene complement(3248321..3248545) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /label="ywzC gene" S_feature complement(3248546..3248630) /Source="Nicolas_S_feature" /locus_tag="new_3861223_3861307_c" /HighExp="G180, Paraq, H2O2, G135, LBGexp, dia15, G150, Lbexp, Heat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1457" promotor_-10 complement(3248619..3248638) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3248629) /Source="Nicolas_upshifts" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3248653..3248656) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3248696..3248702 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3248717..3248728 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3248718 /Source="Nicolas_upshifts" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="upshifts" CDS 3248760..3249536 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10629188, 16497325, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629188, 16497325, 22829778; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="prespore-specific transcription regulatory gene" /protein_id="NP_391642.1" /db_xref="EnsemblGenomes-Gn:BSU37620" /db_xref="EnsemblGenomes-Tr:CAB15789" /db_xref="GOA:P39650" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017877" /db_xref="SubtiList:BG10638" /db_xref="UniProtKB/Swiss-Prot:P39650" /translation="MTKQRQDAWSEENDLLLAETVLRHVREGSTQLNAFEEVGDKLNR TSAACGFRWNAVVRHQYEKALQLAKKQRKQRMRALGNGQPAKKRLLYQPPAVDPEIIQ ETAAEEPVKTETPSVENEQPLMSGEHMPFVDESFKEELASLSHLLSPQTPAAAPEMTM NDVIRFLQNYEGNHEQSSALKMENERLKKENQELQNKTEQLEAEVQKLEKDQKTIQED YETLVKIMNRARKLVLFEEDEHASPSFKMDRNGNLEKLAE*" /label="psrF CDS" gene 3248760..3249536 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /label="psrF gene" downshifts 3249522 /Source="Nicolas_upshifts" /id="D1951" /incds=0 /nref=14 /ntot=78 /MaxReadThrough="4.08166" /MaxDrop="4.36214" /score="-5.88286948" /energy="-14.4" /TU="U2958" /idTUdmin="U2958" /TUdmin="-3036" /isTUend="FALSE" /label="downshifts" promotor_-35 3249624..3249631 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3249646..3249665 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3249650..3253876 /Source="Nicolas_S_feature" /locus_tag="new_3862327_3866553" /HighExp="T1.30H, T2.0H, T1.0H, T2.30H, T0.30H, T3.0H, T3.30H, T4.0H, T5.0H, T0.0H" /AntisenseName="pta" /AntisenseCor="-0.61235087907102503" /AntisenseRegPval="-28.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.836" /TUlongSig="NA" /TUlongPSig="NA" /label="S1458" upshifts 3249650 /Source="Nicolas_upshifts" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3249680..3250570) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative toxic excess metabolite exporter" /protein_id="NP_391643.1" /db_xref="EnsemblGenomes-Gn:BSU37630" /db_xref="EnsemblGenomes-Tr:CAB15790" /db_xref="GOA:P39649" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004779" /db_xref="SubtiList:BG10637" /db_xref="UniProtKB/Swiss-Prot:P39649" /translation="MKGNIYSLFVLIAAFFWGTTGTVQALAPESATPLAFGAFRLLIG GSAMLLAVWISRELHVKNWAWPLVFLAAVCMACYQPLFFTAVKETGIAVGTVIAIGSA PIIAGTLEWAVLKKRPRNSWWIATVLALAGCWLLFSDSSNVRIDVAGVLMALGAGASF AGYTLISKAMMKTQPPRATSAVVFMISAILLTPLLWQLDISWILTPRGLGTSLYIGLI ATCAAYFLFAKGLTGVPASAAVTLSLAEPLTASLLGVFFIGEMLSPSSWLGIALMMLG LLVISAAPRKQKTAEAAHMS*" /label="ywfM CDS" gene complement(3249680..3250570) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /label="ywfM gene" promotor_no_box complement(3250570..3250670) /Source="Nicolas_upshift_promotors" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3250610) /Source="Nicolas_upshifts" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3250738..3251583) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /function="4: Biosynthesis of cofactors, prosthetic groups, and carriers" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidotransferase of the octanoyl moiety from octanoyl-GcvH to the E2 subunit of pyruvate dehydrogenase" /protein_id="NP_391644.1" /db_xref="EnsemblGenomes-Gn:BSU37640" /db_xref="EnsemblGenomes-Tr:CAB15791" /db_xref="GOA:P39648" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024897" /db_xref="SubtiList:BG10636" /db_xref="UniProtKB/Swiss-Prot:P39648" /translation="MANQPIDLLMQPKWRVIDQSSLGPLFDAKQSFAMDDTLCMSVGK GVSPATARSWVHHDTIVLGIQDTRLPFLQDGISLLESEGYRVIVRNSGGLAVVLDDGV LNISLIFEDEKKGIDIDKGYEAMVELMRRMLRPYNAKIEAYEIEGSYCPGSYDLSING KKFAGISQRRVRGGVAVQIYLCADKSGSERADLIRRFYQAALKDKQNDKKGVYPEIRP ETMASLSELLQKDISVQDLMFALLTELKALSTHLYSAGLSIDEEMEFEKNLVRMAERN AKVFG*" /label="lipL CDS" gene complement(3250738..3251583) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /label="lipL gene" downshifts complement(3250901) /Source="Nicolas_upshifts" /id="D1952" /incds=1 /nref=4 /ntot=180 /MaxReadThrough="3.21908" /MaxDrop="3.30122" /score="31.9003746" /energy="-18.6" /TU="U2961" /idTUdmin="U2961" /TUdmin="-27" /isTUend="FALSE" /label="downshifts" CDS complement(3251632..3252531) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sulfur assimilation CysL, activatescysJI expression" /protein_id="NP_391645.1" /db_xref="EnsemblGenomes-Gn:BSU37650" /db_xref="EnsemblGenomes-Tr:CAB15792" /db_xref="GOA:P39647" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10635" /db_xref="UniProtKB/Swiss-Prot:P39647" /translation="MYYDVLKTFIAVVEEKNFTKAAEKLMISQPSVSLHIKNLEKEFQ TALLNRSPKHFTTTPTGDILYQRAKQMVFLYEQAKAEIYAHHHYVKGELKIAASFTIG EYILPPLLAQLQKLYPELNLDVMIGNTEEVSERVRMLQADIGLIEGHTNENELEIEPF MEDEMCIAAPNQHPLAGRKEISISDLQNEAWVTREKGSGTREYLDHVLSSNGLRPKSM FTISSNQGVKEAVINGMGLSVLSRSVLRKDLIHREISILHINNFSLKRKLSYIHSPLM ENTKNKEIFITMLKSNYQSQLLK*" /label="cysL CDS" gene complement(3251632..3252531) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /label="cysL gene" promotor_-10 complement(3252574..3252593) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3252577) /Source="Nicolas_upshifts" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3252607..3252614) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3252678) /Source="Nicolas_upshifts" /id="D1953" /incds=0 /nref=222 /ntot=251 /MaxReadThrough="1.96406" /MaxDrop="7.24606" /score="32.3178773" /energy="-17.3" /TU="NA" /idTUdmin="U2962" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3252678..3253649) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /EC_number="2.3.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphotransacetylase" /protein_id="NP_391646.1" /db_xref="EnsemblGenomes-Gn:BSU37660" /db_xref="EnsemblGenomes-Tr:CAB15793" /db_xref="GOA:P39646" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR004614" /db_xref="InterPro:IPR012147" /db_xref="PDB:1TD9" /db_xref="PDB:1XCO" /db_xref="SubtiList:BG10634" /db_xref="UniProtKB/Swiss-Prot:P39646" /translation="MADLFSTVQEKVAGKDVKIVFPEGLDERILEAVSKLAGNKVLNP IVIGNENEIQAKAKELNLTLGGVKIYDPHTYEGMEDLVQAFVERRKGKATEEQARKAL LDENYFGTMLVYKGLADGLVSGAAHSTADTVRPALQIIKTKEGVKKTSGVFIMARGEE QYVFADCAINIAPDSQDLAEIAIESANTAKMFDIEPRVAMLSFSTKGSAKSDETEKVA DAVKIAKEKAPELTLDGEFQFDAAFVPSVAEKKAPDSEIKGDANVFVFPSLEAGNIGY KIAQRLGNFEAVGPILQGLNMPVNDLSRGCNAEDVYNLALITAAQAL*" /label="pta CDS" gene complement(3252678..3253649) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /label="pta gene" promotor_-10 complement(3253684..3253703) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3253709) /Source="Nicolas_upshifts" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3253719..3253723) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3253797..3253808) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3253800) /Source="Nicolas_upshifts" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3253822..3253828) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3253871..3253890 /Source="Nicolas_upshift_promotors" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3253878 /Source="Nicolas_upshifts" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="upshifts" CDS 3253919..3254683 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /EC_number="4.1.-.-" /function="4.3: Heme, porphyrin, and cobalamin" /experiment="publication(s) with functional evidences, PMID:15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-coproporphyrin (coproheme) decarboxylase" /protein_id="NP_391647.3" /db_xref="EnsemblGenomes-Gn:BSU37670" /db_xref="EnsemblGenomes-Tr:CAB15794" /db_xref="GOA:P39645" /db_xref="InterPro:IPR010644" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR031332" /db_xref="SubtiList:BG10633" /db_xref="UniProtKB/Swiss-Prot:P39645" /translation="MSEQQMTNEAAKTLDGWYALHDFRTMDWASWKLLSSDERQSIIH EFTGLLEKWGVAQKEGKGSQTLYSIVGQKADFMLMILRPTMEELNQIELEFNKSRLAE FTIPAYSYVSVVELSNYLASGDGDPYENPHVRARLYPELPESKYVCFYPMDKRRSGND NWYMLSMEERRNLMRSHGLIGRSYAGKVKQIITGSVGFDDYEWGVTLFSDDVLQFKKL VYEMRFDEVSARYGEFGSFFVGNHLSLDTLPQFLYV*" /label="hemQ CDS" gene 3253919..3254683 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /label="hemQ gene" downshifts 3254670 /Source="Nicolas_upshifts" /id="D1954" /incds=0 /nref=155 /ntot=246 /MaxReadThrough="5.49286" /MaxDrop="6.26609" /score="19.319449" /energy="-14.5" /TU="U2964" /idTUdmin="U2959" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(3254690,3254697) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs11" N_region 3254691..3254696 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs11" S_feature <3254697..3254749 /Source="Nicolas_S_feature" /locus_tag="new_3873771_3874382" /HighExp="Etha, Salt, Gly, Heat, C30, LPhT, HiTm, C90, S8, M/G" /AntisenseName="bacA" /AntisenseCor="9.8443047207874598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1459" CDS complement(3254699..3255937) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15609023, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391655.1" /db_xref="EnsemblGenomes-Gn:BSU37750" /db_xref="EnsemblGenomes-Tr:CAB15802" /db_xref="GOA:P39637" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10625" /db_xref="UniProtKB/Swiss-Prot:P39637" /translation="MNSNQNNDIKTKHHFPLLLALALTMGVFAAGSEELVISPLLPDL AKAFSSDVSVLALSISIYGVMIFIGAPLLVPLGDKYSRELSLLAGLMIFIIGTVICAL AQNIFFFFLGRALSGLAAGAFVPTAYAVVGDRVPYTYRGKVMGLIVSSWSLALIFGVP LGSFIGGVLHWRWTFWIFALMGVLVVLLILLEMRRHAQHKNSGKEEIEEPAGTFRDAL KVPRVPVYITITFCNMIGFYGMYSFLGTYLQDVFTGGNTAAGLFIMIYGIGFSMSVIT GKIADRIGKMRSLLIALGVISVLLACLPYAPASMFLLIASLFIWGLMQSLTVTLLSTI LSDCSERHRGKVMVFYSLASNLAVTLGSALMGPVYVAYGYAAVGLICAAITVLGFVLS VFAYKKYGKLEQKADQSLSQ*" /label="ywfA CDS" gene complement(3254699..3255937) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /label="ywfA gene" promotor_-10 complement(3255979..3255998) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3255991) /Source="Nicolas_upshifts" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3256010..3256017) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3256147..3257559) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7540694, 8113162, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="basic aminoacid permease" /protein_id="NP_391656.1" /db_xref="EnsemblGenomes-Gn:BSU37760" /db_xref="EnsemblGenomes-Tr:CAB15803" /db_xref="GOA:P39636" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10624" /db_xref="UniProtKB/Swiss-Prot:P39636" /translation="MQNHKNELQRSMKSRHLFMIALGGVIGTGLFLGSGFTISQAGPL GAIAAYIIGGFLMYLVMLCLGELAVAMPVAGSFQAYATKFLGQSTGFMIGWLYWFSWA NTVGLELTSAGILMQRWLPSVPIWIWCLVFGIVIFLINALSVRSFAEMEFWFSSIKVA AIILFIVIGGAAVFGLIDFKGGQETPFLSNFMTDRGLFPNGVLAVMFTLVMVNFSFQG TELVGIAAGESESPEKTLPKSIRNVIWRTLFFFVLAMFVLVAILPYKTAGVIESPFVA VLDQIGIPFSADIMNFVILTAILSVANSGLYAASRMMWSLSSNQMGPSFLTRLTKKGV PMNALLITLGISGCSLLTSVMAAETVYLWCISISGMVTVVAWMSICASQFFFRRRFLA EGGNVNDLEFRTPLYPLVPILGFCLYGCVLISLIFIPDQRIGLYCGVPIIIFCYAYYH LSIKKRINHETIEKKQTEAQ*" /label="rocC CDS" gene complement(3256147..3257559) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /label="rocC gene" downshifts complement(3256154) /Source="Nicolas_upshifts" /id="D1957" /incds=0 /nref=16 /ntot=112 /MaxReadThrough="1.06691" /MaxDrop="5.69562" /score="41.626335" /energy="-15.9" /TU="NA" /idTUdmin="U2971" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3257559..3259259) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8113162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase involved in arginine and ornithine utilization" /protein_id="NP_391657.1" /db_xref="EnsemblGenomes-Gn:BSU37770" /db_xref="EnsemblGenomes-Tr:CAB15804" /db_xref="GOA:P39635" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG10623" /db_xref="UniProtKB/Swiss-Prot:P39635" /translation="MQYTKISHMNPAERVEALTASLVSLSSVNGTVGEGTKADFIKEV ITSYPYFQENPSHVWEQAIPNDPYKRKNIFAFIKGHGESRNTVIYHAHLDTVGIEDFG PLKDIAFDCEKLAEYFSRYEFDQDVQRDAKSGEWMFGRGSVDMQSGIAVHLANLLHFS ENLETLPGNVLFMANPDEESQHSGILASISELNRLKKEKQLHYLAAINTDFITPLYDG DQTRYIYTGAAGKLLPCFYIYGREVHVGDTLAGIDPNFISSEITSRLHNNIHLAEKVE GELVLPPSCLYQRDNKESYNVQTAVSTSLYFNCFIYERTAKEMMDLLIEVTEEACRET EQKLSDYYEEYVKRANLPKKHLSWGIQVYSLEQYLEKLRNRGIDPEQCIEQTFKANEH LELRMRCFQAIEELQKLDPDQGAKVILFYAPPYLPHNYLKEDSARDQLLQHVIKEAAD KTAESTGETFVFKKFFPYLADGSFLSLHETDGEIDSFIRNFPGWNMIGTIPFKDIRKL NIPSINMGVYGKDGHKWTERVYKPYTFHVLPLLIQQTTVHLLQSYRMTITAKEPKGEG *" /label="rocB CDS" gene complement(3257559..3259259) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /label="rocB gene" misc_feature complement(3258228..3258244) /Source="Nicolas_upshift_promotors" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3258240) /Source="Nicolas_upshifts" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3259333..3260880) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11418582, 12634342, 8113162, 9383188, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-1-pyrroline-5 carboxylate dehydrogenase" /protein_id="NP_391658.1" /db_xref="EnsemblGenomes-Gn:BSU37780" /db_xref="EnsemblGenomes-Tr:CAB15805" /db_xref="GOA:P39634" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10622" /db_xref="UniProtKB/Swiss-Prot:P39634" /translation="MTVTYAHEPFTDFTEAKNKTAFGESLAFVNTQLGKHYPLVINGE KIETDRKIISINPANKEEIIGYASTADQELAEKAMQAALQAFDSWKKQRPEHRANILF KAAAILRRRKHEFSSYLVKEAGKPWKEADADTAEAIDFLEFYARQMLKLKEGAPVKSR AGEVNQYHYEALGVGIVISPFNFPLAIMAGTAVAAIVTGNTILLKPADAAPVVAAKFV EVMEEAGLPNGVLNYIPGDGAEIGDFLVEHPKTRFVSFTGSRAVGCRIYERAAKVQPG QKWLKRVIAEMGGKDTVLVDKDADLDLAASSIVYSAFGYSGQKCSAGSRAVIHQDVYD EVVEKAVALTKTLTVGNPEDPDTYMGPVIHEASYNKVMKYIEIGKSEGKLLAGGEGDD SKGYFIQPTIFADVDENARLMQEEIFGPVVAICKARDFDHMLEIANNTEYGLTGALLT KNRAHIERAREDFHVGNLYFNRGCTGAIVGYQPFGGFNMSGTDSKAGGPDYLILHMQA KTTSEAF*" /label="rocA CDS" gene complement(3259333..3260880) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /label="rocA gene" downshifts complement(3259340) /Source="Nicolas_upshifts" /id="D1958" /incds=0 /nref=4 /ntot=50 /MaxReadThrough="5.60027" /MaxDrop="3.5628" /score="41.626335" /energy="-15.9" /TU="U2971,U2972" /idTUdmin="U2973" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3260924) /Source="Nicolas_upshifts" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3260926..3261106) /Source="Nicolas_S_feature" /locus_tag="new_3880559_3880739_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1460" misc_feature complement(3260927..3260945) /Source="Nicolas_upshift_promotors" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3261107..3262381) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate dehydrogenase" /protein_id="NP_391659.2" /db_xref="EnsemblGenomes-Gn:BSU37790" /db_xref="EnsemblGenomes-Tr:CAB15806" /db_xref="GOA:P39633" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K92" /db_xref="SubtiList:BG10621" /db_xref="UniProtKB/Swiss-Prot:P39633" /translation="MSAKQVSKDEEKEALNLFLSTQTIIKEALRKLGYPGDMYELMKE PQRMLTVRIPVKMDNGSVKVFTGYRSQHNDAVGPTKGGVRFHPEVNEEEVKALSIWMT LKCGIANLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQIVGPTKDIPAPDVYTN SQIMAWMMDEYSRLREFDSPGFITGKPLVLGGSQGRETATAQGVTICIEEAVKKKGIK LQNARIIIQGFGNAGSFLAKFMHDAGAKVIGISDANGGLYNPDGLDIPYLLDKRDSFG MVTNLFTDVITNEELLEKDCDILVPAAISNQITAKNAHNIQASIVVEAANGPTTIDAT KILNERGVLLVPDILASAGGVTVSYFEWVQNNQGYYWSEEEVAEKLRSVMVSSFETIY QTAATHKVDMRLAAYMTGIRKSAEASRFRGWV*" /label="rocG CDS" gene complement(3261107..3262381) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /label="rocG gene" S_feature complement(3262382..3262464) /Source="Nicolas_S_feature" /locus_tag="new_3882015_3882097_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.83780600000000005" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1461" upshifts complement(3262464) /Source="Nicolas_upshifts" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3262477..3262495) /Source="Nicolas_upshift_promotors" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3262557) /Source="Nicolas_upshifts" /id="D1959" /incds=0 /nref=9 /ntot=144 /MaxReadThrough="4.82066" /MaxDrop="4.13762" /score="22.6949864" /energy="-11.4" /TU="U2973" /idTUdmin="U2977" /TUdmin=369 /isTUend="FALSE" /label="downshifts" CDS complement(3262558..3263022) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /experiment="publication(s) with functional evidences, PMID:15187182, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 28751732; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm protein, member of the processed secretome contributing to biofilm hydrophobicity" /protein_id="NP_391660.1" /db_xref="EnsemblGenomes-Gn:BSU37800" /db_xref="EnsemblGenomes-Tr:CAB15807" /db_xref="GOA:P39632" /db_xref="InterPro:IPR034650" /db_xref="PDB:5MKD" /db_xref="SubtiList:BG10620" /db_xref="UniProtKB/Swiss-Prot:P39632" /translation="MLKRTSFVSSLFISSAVLLSILLPSGQAHAQSASIEAKTVNSTK EWTISDIEVTYKPNAVLSLGAVEFQFPDGFHATTRDSVNGRTLKETQILNDGKTVRLP LTLDLLGASEFDLVMVRKTLPRAGTYTIKGDVVNGLGIGSFYAETQLVIDPR*" /label="bslB CDS" gene complement(3262558..3263022) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /label="bslB gene" S_feature complement(3263023..3263133) /Source="Nicolas_S_feature" /locus_tag="new_3882656_3882766_c" /HighExp="C90, S1, S0, MG 150, M9-tran, LPhT, BI, GM 150, Lbtran, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1462" promotor_-10 complement(3263115..3263134) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-10" upshifts complement(3263133) /Source="Nicolas_upshifts" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="upshifts" promotor_-35 complement(3263149..3263156) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-35" downshifts complement(3263344) /Source="Nicolas_upshifts" /id="D1960" /incds=0 /nref=32 /ntot=80 /MaxReadThrough="3.01999" /MaxDrop="4.92444" /score="6.35246869" /energy="-8.4" /TU="U2977" /idTUdmin="U2977" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(3263346..3263801) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /EC_number="5.1.3.13" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25239894; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-deoxyrhamnose-3,5-epimerase (cell surface and spore coat)" /protein_id="YP_054595.1" /db_xref="EnsemblGenomes-Gn:BSU37810" /db_xref="EnsemblGenomes-Tr:CAE01469" /db_xref="GOA:Q7WY56" /db_xref="InterPro:IPR000888" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG14195" /db_xref="UniProtKB/Swiss-Prot:Q7WY56" /translation="MIDGVKVKKLMKHSDDRGFFAELVRDDENLLEHFGQASWSKSYP GVIKAFHYHEKQDDLWFFPTGHAQVVLYDLREDSKTKGETDVYYMGEDNPMLLLIPKG VAHGYRVLGETPLTIIYFTTMSYNPDQPDEKRIPWDDETIGFNWNTEFR*" /label="spsL CDS" gene complement(3263346..3263801) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /label="spsL gene" misc_feature 3263436..3263455 /Source="Nicolas_upshift_promotors" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3263444 /Source="Nicolas_upshifts" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3263794..3264645) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /EC_number="1.1.1.133" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-dehydrorhamnose reductase" /protein_id="NP_391661.3" /db_xref="EnsemblGenomes-Gn:BSU37820" /db_xref="EnsemblGenomes-Tr:CAB15808" /db_xref="GOA:P39631" /db_xref="InterPro:IPR005913" /db_xref="InterPro:IPR029903" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10619" /db_xref="UniProtKB/Swiss-Prot:P39631" /translation="MTKVLVTGAGGQLGLELCRQLKQAGYEVIALTKKMMNIADQRSV RHSFGHYQPDIVVNSAAFTSVDQCEKELDKAYLINGIGAYYTALESTRIGAQYVHIST DYVFNGKGTQPYREDDPLDPKTIYGKSKRLGEELIRLTTKDSTIIRTSWVYGHGGSNF VETMLKLAETKQELRVVSDQIGSPTYTKDLAEAVIKLFSHPPGIYHVSNSGICSWYEF ATAIMEESGLETAILSVTTEEYGNKTPRPAYSVLSHRAIEEAGIRPRHWREALREYLQ ERSSACD*" /label="spsK CDS" gene complement(3263794..3264645) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /label="spsK gene" CDS complement(3264659..3265606) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /EC_number="4.2.1.46" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dTDP-glucose 4,6-dehydratase" /protein_id="NP_391662.1" /db_xref="EnsemblGenomes-Gn:BSU37830" /db_xref="EnsemblGenomes-Tr:CAB15809" /db_xref="GOA:P39630" /db_xref="InterPro:IPR005888" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10618" /db_xref="UniProtKB/Swiss-Prot:P39630" /translation="MAKSYLITGGAGFIGLTFTKLMLRETDARITVLDKLTYASHPEE MEKLKQNSRFRFVKGDISVQEDIDRAFDETYDGVIHFAAESHVDRSISQAEPFITTNV MGTYRLAEAVLKGKAKKLIHISTDEVYGDLKADDPAFTETTPLSPNNPYSASKASSDL LVLSYVKTHKLPAIITRCSNNYGPYQHSEKMIPTIIRHAKQGLPVPLYGDGLQIRDWL FAEDHCRAIKLILEKGTDGEVYNIGGGNERTNKELASVILKHLGCEELFAHVEDRKGH DRRYAINASKLKNELGWRQEVTFEEGIARTIQWYTDNDR*" /label="spsJ CDS" gene complement(3264659..3265606) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /label="spsJ gene" CDS complement(3265606..3266346) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /EC_number="2.7.7.24" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate thymidylyltransferase" /protein_id="NP_391663.1" /db_xref="EnsemblGenomes-Gn:BSU37840" /db_xref="EnsemblGenomes-Tr:CAB15810" /db_xref="GOA:P39629" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005907" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10617" /db_xref="UniProtKB/Swiss-Prot:P39629" /translation="MKGVILAGGNGSRLMPLTKAVNKHLLPVGPYPMIYWSIMKLQEA GIKDILLISQKEHMPQFYKLLGNGEELGVTITYQVQPAASGISDGLSYAKRFTKKESF ILLLGDNIFEDSLKPYTERFEQQGKGAKVLLKEVDDPERFGIAEIDEKNKRIRSIIEK PEQPPTNLCVTGIYMYDAEVFSYIEQISPSKRGELEITDVNNLYIENSQLTYDVLSGW WVDAGTHESLYLASQLVHQALRKGQDEK*" /label="spsI CDS" gene complement(3265606..3266346) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /label="spsI gene" promotor_-35 3266364..3266369 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3266370 /Source="Nicolas_upshifts" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3266371..3267390) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391664.1" /db_xref="EnsemblGenomes-Gn:BSU37850" /db_xref="EnsemblGenomes-Tr:CAB15811" /db_xref="GOA:P39627" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10615" /db_xref="UniProtKB/Swiss-Prot:P39627" /translation="MHVGIFADGGYEKGMGHVVRMKRLAEGLKQRCLITFYTNQDSEA FLHEEHWQVIVKPELQQHEFILREIKSKKLDLLLFDILGAPAELLKKIKTETDAKIVL FEEKNGKSIQYSDAVINGIYGDIRSRVYVQGNTRIYEGPDYLILHPAFQAAREDYTLK KDCRNILVALGGSDPKQLIFKVLAAADQVPDIKDKNMMFVMGSASPHQEAVRRRIEKK PQYKMIEQTNDMAGLMKQADAAIVAGGISLYEAICIGVPCLVLSQVEHQTATAKTFAD QGAALDLGLGELVPDETLIYQMSRIMSSYPLRLSLHKGGRPLVDGKGIIRVTAILQDL YEQEI*" /label="spsG CDS" gene complement(3266371..3267390) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /label="spsG gene" promotor_-10 3266384..3266402 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3267254..3267263 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3267276..3267291 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3267287 /Source="Nicolas_upshifts" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3267393..3268115) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391665.2" /db_xref="EnsemblGenomes-Gn:BSU37860" /db_xref="EnsemblGenomes-Tr:CAB15812" /db_xref="InterPro:IPR003329" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10614" /db_xref="UniProtKB/Swiss-Prot:P39626" /translation="MNDILFIIQARMGSTRLPGKVLRPLGSNRLLDILVHRVRQSAFY QKDRDNLVIATSDKETDDILEAHCIKQGFRVFRGSEERVLDRFVKVIEAVKPSVIIRL TGDNPFVDPELLDVMIQAHFDQGSDYTYILNAPLGICGEVVNANLLIDISRIQALEDQ YQEHVTLYIRNHPALYRVQFLEAPERFRAPQYRLTIDTKEDYESIKALYQKAGERPDV SASELITLLNRNPDAATEREAD*" /label="spsF CDS" gene complement(3267393..3268115) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /label="spsF gene" CDS complement(3268108..3269229) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /EC_number="2.5.-.-" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12597896, 15774001; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoenolpyruvate-sugar pyruvyltransferase" /protein_id="NP_391666.1" /db_xref="EnsemblGenomes-Gn:BSU37870" /db_xref="EnsemblGenomes-Tr:CAB15813" /db_xref="GOA:P39625" /db_xref="InterPro:IPR006190" /db_xref="InterPro:IPR013132" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR036732" /db_xref="PDB:1VLI" /db_xref="SubtiList:BG10613" /db_xref="UniProtKB/Swiss-Prot:P39625" /translation="MAAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEA GADAVKFQMFQADRMYQKDPGLYKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQ VIFLSTVCDEGSADLLQSTSPSAFKIASYEINHLPLLKYVARLNRPMIFSTAGAEISD VHEAWRTIRAEGNNQIAIMHCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHP TEAPCAAVRLGAKLIEKHFTIDKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGIT KPVSEKLLGSSYKTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQG LHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE*" /label="spsE CDS" gene complement(3268108..3269229) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /label="spsE gene" CDS complement(3269229..3270098) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative TDP-glycosamine N-acetyltransferase" /protein_id="NP_391667.1" /db_xref="EnsemblGenomes-Gn:BSU37880" /db_xref="EnsemblGenomes-Tr:CAB15814" /db_xref="GOA:P39624" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10612" /db_xref="UniProtKB/Swiss-Prot:P39624" /translation="MYTVKENVSKEAIEEFLQSRKLTLDVPYQFSLGLFENSRLQGVL LYEDSLWESKVLQKKVMNVKLLAANSTGQLKRLFEAFYTVRQMDETDFIFVRVPAEDI GAAHVIQQQPSSYFVGSLLKLAMPPSFYDKTPPFFELGPPEPGDTEAICELARDSFTK SRYFQDPHLSRDAANEIFQEWTRNNLNGRAAVNIVAKHNGEVIGYLQGLSRDDECILD LMAVKPGFEGKRIAFHLLANLIEQPETQKHRTVTAGTQLHNVRAIRLYERMGFTAEQS YYYYHIWPGKEAK*" /label="spsD CDS" gene complement(3269229..3270098) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /label="spsD gene" CDS complement(3270099..3271268) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /EC_number="2.6.1.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14602648; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glutamine-dependent sugar transaminase" /protein_id="NP_391668.1" /db_xref="EnsemblGenomes-Gn:BSU37890" /db_xref="EnsemblGenomes-Tr:CAB15815" /db_xref="GOA:P39623" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10611" /db_xref="UniProtKB/Swiss-Prot:P39623" /translation="MVQKRNHFLPYSLPLIGKEEIQEVTETLESGWLSKGPKVQQFEK EFAAFVGAKHAVAVNSCTAALFLALKAKGIGPGDEVITSPLTFSSTANTIIHTGATPV FADIDENTLNIDPVKLEAAVTPRTKAVVPVHFGGQSCDMDAILAVAQNHGLFVLEDAA HAVYTTYKQRMIGSIGDATAFSFYATKNLATGEGGMLTTDDEELADKIRVLSLHGMSK AAWNRYSSNGSWYYEVESPGYKMNMFDLQAALGLHQLKRLDDMQKRREEIAGRYQTAF QQIPGLITPFVHDDGRHAWHLYVLQVDEKKAGVTRSEMITALKDEYNIGTSVHFIPVH IHPYYQKQFGYKEADFPNAMNYYKRTLSLPLYPSMSDDDVDDVIEAVRDIVKGAD*" /label="spsC CDS" gene complement(3270099..3271268) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /label="spsC gene" CDS complement(3271289..3272713) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22611084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP glycosyl/glycerophosphate transferase or transport" /protein_id="NP_391669.2" /db_xref="EnsemblGenomes-Gn:BSU37900" /db_xref="EnsemblGenomes-Tr:CAB15816" /db_xref="GOA:P39622" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10610" /db_xref="UniProtKB/Swiss-Prot:P39622" /translation="MSAYLSNYWVLYRKYVELFDKLRYKGIPLGLISNFYQYISPELR VMMEEEPELFGSVDQHIDEGQIQPFFEERIQNIVKTNDEPVKGKVILHFDYLRFSNEN YYQFDPEKTAVLARWSLPHYCDLPVISKREIADSCQKGDSKQYLETACSLLAPYDDHP AFGDQAFRDRLFKDIPLFIEAIDTVDALFEQEKISAVIVGTAEDIYSRVLALMCQRKG AVSICLQHGALMGDEAFIPVFTTYQAVFGAYEAEWFIRKGCKPEQILVTGHPRFDQIF NRTPMDMSIFYRKLAFQPTKKIVLIATQPFSEDFYSGVLQGLSDQKQLQIIIKPHPWE IGKNKLDLYHEAAKKHQACRVIKKELELYDLLPYVDAAVTQTSTVGLEAMLFQKPVLI GKSSGNRSYPYYESLGDFMFDQPDELAHTLVEVLRSPDVHQKAEEARLAFIAANYPVA ESTNALFAELKAKTGVDYRREDTE*" /label="spsB CDS" gene complement(3271289..3272713) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /label="spsB gene" CDS complement(3272718..3273488) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10350455, 11042447, 11733986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10350455, 11042447, 11733986; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat dTDP-glycosyltransferase" /protein_id="NP_391670.1" /db_xref="EnsemblGenomes-Gn:BSU37910" /db_xref="EnsemblGenomes-Tr:CAB15817" /db_xref="GOA:P39621" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PDB:1H7L" /db_xref="PDB:1H7Q" /db_xref="PDB:1QG8" /db_xref="PDB:1QGQ" /db_xref="PDB:1QGS" /db_xref="SubtiList:BG10609" /db_xref="UniProtKB/Swiss-Prot:P39621" /translation="MPKVSVIMTSYNKSDYVAKSISSILSQTFSDFELFIMDDNSNEE TLNVIRPFLNDNRVRFYQSDISGVKERTEKTRYAALINQAIEMAEGEYITYATDDNIY MPDRLLKMVRELDTHPEKAVIYSASKTYHLNENRDIVKETVRPAAQVTWNAPCAIDHC SVMHRYSVLEKVKEKFGSYWDESPAFYRIGDARFFWRVNHFYPFYPLDEELDLNYITD QSIHFQLFELEKNEFVRNLPPQRNCRELRESLKKLGMG*" /label="spsA CDS" gene complement(3272718..3273488) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /label="spsA gene" promotor_-10 complement(3273523..3273542) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3273537) /Source="Nicolas_upshifts" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3273556..3273565) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3273656..3273661 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3273677..3273695 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3273679..3273807 /Source="Nicolas_S_feature" /locus_tag="new_3893312_3893440" /HighExp="S5, S4, S3, S7, B36, S8, S6, B60, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1463" upshifts 3273679 /Source="Nicolas_upshifts" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="upshifts" CDS 3273808..3274353 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12644503, 15317760, 16936016, 16936016, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12644503, 15317760, 16936016, 16936016, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391671.1" /db_xref="EnsemblGenomes-Gn:BSU37920" /db_xref="EnsemblGenomes-Tr:CAB15818" /db_xref="GOA:P39620" /db_xref="InterPro:IPR014099" /db_xref="SubtiList:BG10608" /db_xref="UniProtKB/Swiss-Prot:P39620" /translation="MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQ PMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPTPSGPGQSVPGMLPVEESYIENI LRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDY ITFDEEIAYTYPYSMASYSPR*" /label="gerQ CDS" gene 3273808..3274353 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /label="gerQ gene" downshifts 3274339 /Source="Nicolas_upshifts" /id="D1961" /incds=0 /nref=60 /ntot=77 /MaxReadThrough="1.98659" /MaxDrop="7.96105" /score="16.9179802" /energy="-11.7" /TU="NA" /idTUdmin="U2978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3274397..3274768) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15919996, 21810204; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391672.2" /db_xref="EnsemblGenomes-Gn:BSU37930" /db_xref="EnsemblGenomes-Tr:CAB15819" /db_xref="GOA:P39619" /db_xref="InterPro:IPR006696" /db_xref="SubtiList:BG10607" /db_xref="UniProtKB/Swiss-Prot:P39619" /translation="MKVFIILGAINALLAVGLGAFGAHGLEGKIPDKYLQVWHTGVQY HMYHALGLFVVAFLADKLSGIGSVTTAGWLMFAGIVLFSGSLYILSVTQISILGAITP LGGVAFIISWIMIVVAAVKYL*" /label="ywdK CDS" gene complement(3274397..3274768) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /label="ywdK gene" downshifts complement(3274415) /Source="Nicolas_upshifts" /id="D1962" /incds=0 /nref=134 /ntot=227 /MaxReadThrough="3.65585" /MaxDrop="4.84049" /score="15.105437" /energy="-11.7" /TU="NA" /idTUdmin="U2979" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3274830..3276152) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine/pyrimidine permease" /protein_id="NP_391673.2" /db_xref="EnsemblGenomes-Gn:BSU37940" /db_xref="EnsemblGenomes-Tr:CAB15820" /db_xref="GOA:P39618" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="SubtiList:BG10606" /db_xref="UniProtKB/Swiss-Prot:P39618" /translation="MKLVLGALQWTAFIIAAAIVVPVAVAQSFHLDHSDSARLIQSTF FVLGIAAVIQCLKGHRLPINESPAGLWWGVYTIYAGLTGTVFATYGDTLRGLQGALLV SAVCFFLLSVFKVIDRLAKLFTPVVTGVYLLLLVMQLSQPIIKGILGIGYRQDGVDGL VFGLALVVIAAAFIMTNSNIMFFKQYSILLALFGGWVLFAAAGAAKPIEMPDRLFQLP SLFPFGTPLFNSGLIITSIFITILLIVNMLASMKVVDIAMKKFSKQPDGKHHERHAGF AASFSHLLSGLTGAIAPVPISGAAGFIETTKMPSKKPFMLGSILVIVISVIPFFMNTF ASLPSPVGFAVNFVVFSAMGGLAFAEFDSYEKEESKRVRSIIGISLLTGVGIMFVPET ALKGLHPVFISLLSNGLVLGTLAAIAADQFQLWRRRKSDNLVSTENKH*" /label="ywdJ CDS" gene complement(3274830..3276152) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /label="ywdJ gene" CDS complement(3276172..3276489) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391674.3" /db_xref="EnsemblGenomes-Gn:BSU37950" /db_xref="EnsemblGenomes-Tr:CAB15821" /db_xref="InterPro:IPR035218" /db_xref="SubtiList:BG10605" /db_xref="UniProtKB/Swiss-Prot:P39617" /translation="MNIHISALIQKMEEELKKAKTAERDEELKRYVAVVRSLCDVVLD QPENASAPRIQPSVTPSPAAPPSTDQLMMEKMMGSAGLNKYRKQEKEKQEEDGNGESL FDF*" /label="ywdI CDS" gene complement(3276172..3276489) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /label="ywdI gene" promotor_-10 complement(3276518..3276537) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3276529) /Source="Nicolas_upshifts" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3276551..3276557) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3276592..3276599 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3276615..3276634 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3276618 /Source="Nicolas_upshifts" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="upshifts" CDS 3276657..3278027 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391675.2" /db_xref="EnsemblGenomes-Gn:BSU37960" /db_xref="EnsemblGenomes-Tr:CAB15822" /db_xref="GOA:P39616" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10604" /db_xref="UniProtKB/Swiss-Prot:P39616" /translation="MNSIPSIISKHKAYFAAGHTRPLESRLNILRKLKQAVRTHEADL IAALYQDLHKSEQEAYSTEIGIVLEEISFVMKRLRKWSKPKRVKTPLTHLGSKSIIIP EPYGTVLVIAPWNYPLQLALSPLIGAIAAGNTVVLKPSEYTPAVSAILSKLISSVFPT DYVAMAEGGPDVSTALLQQPFDYIFFTGSVAVGKIVMEAAAKQLIPVTLELGGKSPCI VHKDADIQLAAKRIVFGKFTNAGQTCIAPDYLFVHEDIKTKLTEEMKRAIREFYGPQP ERNPQYGKIVSERHYQRLLSFLNDGIPLTGGQSDPNHHKIAPTILEQVRDDSPVMQEE IFGPILPLFTYRNIGEVIEKVQSRPKPLALYLFTTNKEIERAVLGNLSFGGGCVNDTL MHVATPYLPFGGVGESGIGSYHGFDSFNTFTHKKSVVKQTNRFDFAFRYPSSKNGLRM IRKILK*" /label="ywdH CDS" gene 3276657..3278027 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /label="ywdH gene" CDS complement(3278052..3278729) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /EC_number="3.2.2.27" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1902430, 9776748, 10080896, 21542855, 22056936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1902430, 9776748, 10080896, 21542855, 22056936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil-DNA glycosylase" /protein_id="NP_391676.1" /db_xref="EnsemblGenomes-Gn:BSU37970" /db_xref="EnsemblGenomes-Tr:CAB15823" /db_xref="GOA:P39615" /db_xref="InterPro:IPR002043" /db_xref="InterPro:IPR005122" /db_xref="InterPro:IPR018085" /db_xref="InterPro:IPR036895" /db_xref="PDB:3ZOQ" /db_xref="PDB:3ZOR" /db_xref="SubtiList:BG10603" /db_xref="UniProtKB/Swiss-Prot:P39615" /translation="MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRD IFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSVKPGVKQPPSLKNIFLELQQDIG CSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVI FILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPI DWCIKDL*" /label="ung CDS" gene complement(3278052..3278729) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /label="ung gene" downshifts complement(3278066) /Source="Nicolas_upshifts" /id="D1963" /incds=0 /nref=66 /ntot=224 /MaxReadThrough="2.25259" /MaxDrop="4.72154" /score="26.8023311" /energy="-9.1" /TU="NA" /idTUdmin="U2982" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3278556..3278575) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3278572) /Source="Nicolas_upshifts" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3278591..3278596) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3278743..3279549) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /EC_number="2.4.-.-" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9334165; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391677.1" /db_xref="EnsemblGenomes-Gn:BSU37980" /db_xref="EnsemblGenomes-Tr:CAB15824" /db_xref="GOA:P39614" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10602" /db_xref="UniProtKB/Swiss-Prot:P39614" /translation="MKISIVIVTYNRIPALCELLESISRQTLMPYEIIIVNDAGESVV PVKALYPELPIAVINLEKNSGHVAARNAGVKEASGDCIMLCDDDDFFTPGHIEKMAKE IETADFVHSDAEIVSFEEKNGTRYPVSRKLFAYTADYEDMRVFSTYVPSGSMYRRFLH DEIGYFDADVHNYWDWDFYLRAAKDYRVKRVPCASVIYAFSDAGDNQSADLGAKRKQY LDRLSEKHGLGELPTKNFAVLLEEPEMKRREAKSEMVWDGEPVYSRLHRS*" /label="ywdF CDS" gene complement(3278743..3279549) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /label="ywdF gene" promotor_-10 complement(3279042..3279060) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3279056) /Source="Nicolas_upshifts" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3279075..3279081) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3279578..3279597) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3279584) /Source="Nicolas_upshifts" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3279613..3279620) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3279639..3280172) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391678.1" /db_xref="EnsemblGenomes-Gn:BSU37990" /db_xref="EnsemblGenomes-Tr:CAB15825" /db_xref="GOA:P39613" /db_xref="SubtiList:BG10601" /db_xref="UniProtKB/Swiss-Prot:P39613" /translation="MRISSCLYGFVAHGAVFLFTGGCMLLAMAASLPFVFLLDRLPDV VFTAGAILTLLCSYAYVWFWAVRFAYNQKMRLFEVQLGSFVLLALMISLFLLDGSSMK DIMMNWDDAGCAFVPPAFTFLCLSYALVLLPVYQSKLWRLILPNGVRMKDIFHVFGDL MLIMVLLIGATLLFLSL*" /label="ywdE CDS" gene complement(3279639..3280172) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /label="ywdE gene" CDS complement(3280220..3280855) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391679.2" /db_xref="EnsemblGenomes-Gn:BSU38000" /db_xref="EnsemblGenomes-Tr:CAB15826" /db_xref="GOA:P39612" /db_xref="SubtiList:BG10600" /db_xref="UniProtKB/Swiss-Prot:P39612" /translation="MDKETYVSEIKSGLKGLPEGEAMIEEIESHIEHHLFRSFQEGKS EEEAMQTLLQAFGTPTDIVSSFKKIQPVTFRAFLMFHLFCNSALFAVGIAITIMHVWL ESPFVQAVWKGISVSVWLILAAYMIYWVLIGYQGVKEFGKRGEKLVLHTILISMVPNV IFMLVFLFNVIPAALFQSLLTPWFVGTCAFATLLFPLFGRMGCYIGRRQLV*" /label="ywdD CDS" gene complement(3280220..3280855) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /label="ywdD gene" CDS complement(3280848..3281186) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator, PadR family" /protein_id="YP_003097793.1" /db_xref="EnsemblGenomes-Gn:BSU38018" /db_xref="EnsemblGenomes-Tr:CAX52706" /db_xref="GOA:C0H3S6" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3S6" /translation="MLNRELVKGSTVILVLTLLNERPMYGYELVKEMGSRSGNELQMK EGTLYPSLHKLERQGYISSYWEKQEKGPDRKYYRITDEGKEVLAERTKEWSVFSAMMD RILKWSGQNG*" /label="ywzG CDS" gene complement(3280848..3281186) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /label="ywzG gene" promotor_-10 complement(3281208..3281227) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3281219) /Source="Nicolas_upshifts" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3281242..3281249) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3281270..3281273 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3281288..3281307 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3281288 /Source="Nicolas_upshifts" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="upshifts" CDS 3281330..3282145 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /EC_number="2.7.1.35" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14973012, 17012797" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14973012, 17012797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyridoxine, pyridoxal, and pyridoxamine kinase" /protein_id="NP_391681.1" /db_xref="EnsemblGenomes-Gn:BSU38020" /db_xref="EnsemblGenomes-Tr:CAB15828" /db_xref="GOA:P39610" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="PDB:2I5B" /db_xref="SubtiList:BG10598" /db_xref="UniProtKB/Swiss-Prot:P39610" /translation="MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAM DPNNSWNHQVFPIDTDTIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLK NVVIDPVMVCKGANEVLYPEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDM IEAAKKIHALGAQYVVITGGGKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTF SAAVTAELAKGAEVKEAIYAAKEFITAAIKESFPLNQYVGPTKHSALRLNQQS*" /label="pdxK CDS" gene 3281330..3282145 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /label="pdxK gene" downshifts 3282124 /Source="Nicolas_upshifts" /id="D1964" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="2.56759" /MaxDrop="5.39956" /score="22.0760698" /energy="-18.1" /TU="NA" /idTUdmin="U2985" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3282200) /Source="Nicolas_upshifts" /id="D1965" /incds=0 /nref=20 /ntot=111 /MaxReadThrough="0.56945" /MaxDrop="6.81686" /score="39.7901804" /energy="-16.8" /TU="NA" /idTUdmin="U2987" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3282235..3282483) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391682.1" /db_xref="EnsemblGenomes-Gn:BSU38030" /db_xref="EnsemblGenomes-Tr:CAB15829" /db_xref="SubtiList:BG10597" /db_xref="UniProtKB/Swiss-Prot:P39609" /translation="MNIHEQKITPECLEKAANQVEDKREEYKDVLLQLKKMLGGTTPH SETAEILTRAYEQMKEYALFVQSIETFLRKSANNLKIK*" /label="ywdA CDS" gene complement(3282235..3282483) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /label="ywdA gene" downshifts complement(3282255) /Source="Nicolas_upshifts" /id="D1966" /incds=0 /nref=6 /ntot=123 /MaxReadThrough="6.75845" /MaxDrop="3.89221" /score="22.6408081" /energy="-10.8" /TU="U2987,U2988" /idTUdmin="U2986" /TUdmin=11 /isTUend="TRUE" /label="downshifts" upshifts complement(3282501) /Source="Nicolas_upshifts" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3282503..3282576) /Source="Nicolas_S_feature" /locus_tag="new_3902136_3902209_c" /HighExp="G150, Mt0, Diami, Lbexp, dia0, dia5, T0.30H, Oxctl, Etha, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.536, 0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1464" misc_feature complement(3282511..3282517) /Source="Nicolas_upshift_promotors" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3282577..3284016) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /EC_number="3.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3100393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sucrose-6-phosphate hydrolase" /protein_id="NP_391683.2" /db_xref="EnsemblGenomes-Gn:BSU38040" /db_xref="EnsemblGenomes-Tr:CAB15830" /db_xref="GOA:P07819" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR006232" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG10596" /db_xref="UniProtKB/Swiss-Prot:P07819" /translation="MTAHDQELRRRAYEEVEKKEPIANSDPHRQHFHIMPPVGLLNDP NGVIYWKGSYHVFFQWQPFQTGHGAKFWGHYTTQDVVNWKREEIALAPSDWFDKNGCY SGSAVTKDDRLYLFYTGNVRDQDGNRETYQCLAVSDDGLSFEKKGVVARLPEGYTAHF RDPKVWEHEGTWYMVIGAQTENLKGQAVLFASDNLTEWRFLGPITGAGFNGLDDFGYM WECPDLFSLQGSDVLIVSPQGLEADGFRYQNVYQSGYFVGRLDYNKPELKHGEFTELD QGFDFYAPQTLEDDQGRRILFAWMAVPDQDEGSHPTIDCHWIHCMTLPRQLTLSGQKL IQQPLPELKAMRRNEKKIHINMHGSSGALPVEKPERTEILLEDIHTESGFSISIRGTA TFSFHKDEGIVTLERKSFDGKRTEARHCRIKDLHTVHMFLDASSVEIFINNGEEVLSA RYFPFPGNHEVTASATGKSEMNVGIWTLM*" /label="sacA CDS" gene complement(3282577..3284016) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /label="sacA gene" CDS complement(3284013..3285398) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /EC_number="2.7.1.211" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1577686, 3122206, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 3122206, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) sucrose-specificenzyme IIBC component" /protein_id="NP_391684.3" /db_xref="EnsemblGenomes-Gn:BSU38050" /db_xref="EnsemblGenomes-Tr:CAB15831" /db_xref="GOA:P05306" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10595" /db_xref="UniProtKB/Swiss-Prot:P05306" /translation="MDYKETAKRLIELLGGKENIISAAHCATRLRLVMKDESKIDQAQ VEELDGVKGAFSSSGQYQIIFGTGLVNKVFDAFSKEADIEREEHVNHQDAAKEKLNPA ARFAKTLSNIFVPIIPAIVASGLLMGLLGMINAFHWMSKDSALLQLLDMFSSAAFIFL PILIGVSASKEFGSNPYLGAVIGGIMIHPNLLNPWGLAEATPDYMHLFGFDIALLGYQ GTVIPVLLAVYVMSKVEKWTRKVVPHAVDLLVTPFVTVIVTGFVAFIAIGPLGRALGS GITVALTYVYDHAGFVAGLIFGGTYSLIVLTGVHHSFHAIEAGLIADIGKNYLLPIWS MANVAQGGAGLAVFFMAKKAKTKEIALPAAFSAFLGITEPVIFGVNLRYRKPFIAAMI GGALGGAYVVFTHVAANAYGLTGIPMIAIAAPFGFSNLIHYLIGMAIAAVSAFIAAFV MKINEDEERKK*" /label="sacP CDS" gene complement(3284013..3285398) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /label="sacP gene" misc_feature complement(3285417..3285426) /Source="Nicolas_upshift_promotors" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3285431) /Source="Nicolas_upshifts" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3285433..3285497) /Source="Nicolas_S_feature" /locus_tag="new_3905066_3905130_c" /HighExp="Diami, G150, dia5, Mt0, M9-stat, Lbtran, Gly, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1465" promotor_-10 complement(3285476..3285493) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3285497) /Source="Nicolas_upshifts" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3285509..3285516) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3285539..3285558) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3285557) /Source="Nicolas_upshifts" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3285572..3285579) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3285638..3285641 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3285648 /Source="Nicolas_upshifts" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3285656..3285675 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3285700..3286470 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16207915, 16428414, 16850406, 18691156; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite transporter" /protein_id="NP_391685.1" /db_xref="EnsemblGenomes-Gn:BSU38060" /db_xref="EnsemblGenomes-Tr:CAB15832" /db_xref="GOA:P39608" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG10594" /db_xref="UniProtKB/Swiss-Prot:P39608" /translation="METQALQKVEQYALKKQNIFASSKIRYVLRSILASIFIGFGITA ASKTGSYFFMADSPFAFPAAAVTFGAAILMIAYGGGDLFTGNTFYFTYTALRKKISWR DTLYLWMSSYAGNLIGAILFAILISATGLFEEPSVHSFLIHLAEHKMEPPASELFFRG MLCNWLVCLAFFIPMSLKGEGAKLFTMMLFVFCFFISGFEHSIANMCTFAISLLIEHP DTVTLMGAVRNLIPVTLGNLTAGIVMMGWMYYTLNPDQ*" /label="nirC CDS" gene 3285700..3286470 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /label="nirC gene" S_feature 3286471..3287538 /Source="Nicolas_S_feature" /locus_tag="new_3906104_3907171" /HighExp="S0, ferm, M0t45, Lbexp, Mal, dia0, M/G, UNK1, M40t45, BI" /AntisenseName="sacT" /AntisenseCor="-0.34218080984654098" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1466" CDS complement(3286509..3287339) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1577686, 2163394, 8535520, 8702561, 19202299, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 2163394, 8535520, 8702561, 19202299, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator of sacAP expression" /protein_id="NP_391686.1" /db_xref="EnsemblGenomes-Gn:BSU38070" /db_xref="EnsemblGenomes-Tr:CAB15833" /db_xref="GOA:P26212" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="SubtiList:BG10593" /db_xref="UniProtKB/Swiss-Prot:P26212" /translation="MKIYKVLNNNAALIKEDDQEKIVMGPGIAFQKKKNDLIPMNKVE KIFVVRDENEKFKQILQTLPEEHIEIAEDIISYAEGELAAPLSDHIHIALSDHLSFAI ERIQNGLLVQNKLLHEIKALYKKEYEIGLWAIGHVKETLGVSLPEDEAGYIALHIHTA KMDAESMYSALKHTTMIKEMIEKIKQYFNRKVDENSISYQRLVTHLRYAVSRLESNEA LHRMDEEMLYFIQKKYSFAYQCALELAEFLKNEYQLHLPESEAGYITLHVQRLQDLSE *" /label="sacT CDS" gene complement(3286509..3287339) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /label="sacT gene" downshifts complement(3286510) /Source="Nicolas_upshifts" /id="D1967" /incds=0 /nref=49 /ntot=139 /MaxReadThrough="3.34691" /MaxDrop="4.9787" /score="11.2756812" /energy="-8.1" /TU="U2992" /idTUdmin="U2991" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3287365..3287384) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3287371) /Source="Nicolas_upshifts" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3287379..3287681) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391687.2" /db_xref="EnsemblGenomes-Gn:BSU38080" /db_xref="EnsemblGenomes-Tr:CAB15834" /db_xref="SubtiList:BG10592" /db_xref="UniProtKB/Swiss-Prot:P39607" /translation="MKRLLVSLRVWMVFLMNWVTPDRKTAAAAVYSAQRTYQRKAAVQ AAGLVSFYEWRMAVNEEEKQKAKAAALYKRRCLQAFKESPKQERAGPHLYMAVKRR*" /label="ywcI CDS" gene complement(3287379..3287681) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /label="ywcI gene" promotor_-35 complement(3287399..3287406) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3287682..3287820) /Source="Nicolas_S_feature" /locus_tag="new_3907315_3907453_c" /HighExp="T5.0H, M9-stat, S2, S4, T4.0H, S3, T3.30H, LoTm, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.823" /TUlongSig="NA" /TUlongPSig="NA" /label="S1467" misc_feature complement(3287805..3287824) /Source="Nicolas_upshift_promotors" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3287820) /Source="Nicolas_upshifts" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3288135..3288143 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3288154..3288172 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3288155 /Source="Nicolas_upshifts" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="upshifts" CDS 3288211..3290631 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15205417, 15596354, 16946274, 17666034, 18689487, 25666135" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15205417, 15596354, 16946274, 17666034, 18689487, 25666135; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391688.1" /db_xref="EnsemblGenomes-Gn:BSU38090" /db_xref="EnsemblGenomes-Tr:CAB15835" /db_xref="GOA:P29141" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR025965" /db_xref="InterPro:IPR034213" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10591" /db_xref="UniProtKB/Swiss-Prot:P29141" /translation="MKKGIIRFLLVSFVLFFALSTGITGVQAAPASSKTSADLEKAEV FGDIDMTTSKKTTVIVELKEKSLAEAKEAGESQSKSKLKTARTKAKNKAIKAVKNGKV NREYEQVFSGFSMKLPANEIPKLLAVKDVKAVYPNVTYKTDNMKDKDVTISEDAVSPQ MDDSAPYIGANDAWDLGYTGKGIKVAIIDTGVEYNHPDLKKNFGQYKGYDFVDNDYDP KETPTGDPRGEATDHGTHVAGTVAANGTIKGVAPDATLLAYRVLGPGGSGTTENVIAG VERAVQDGADVMNLSLGNSLNNPDWATSTALDWAMSEGVVAVTSNGNSGPNGWTVGSP GTSREAISVGATQLPLNEYAVTFGSYSSAKVMGYNKEDDVKALNNKEVELVEAGIGEA KDFEGKDLTGKVAVVKRGSIAFVDKADNAKKAGAIGMVVYNNLSGEIEANVPGMSVPT IKLSLEDGEKLVSALKAGETKTTFKLTVSKALGEQVADFSSRGPVMDTWMIKPDISAP GVNIVSTIPTHDPDHPYGYGSKQGTSMASPHIAGAVAVIKQAKPKWSVEQIKAAIMNT AVTLKDSDGEVYPHNAQGAGSARIMNAIKADSLVSPGSYSYGTFLKENGNETKNETFT IENQSSIRKSYTLEYSFNGSGISTSGTSRVVIPAHQTGKATAKVKVNTKKTKAGTYEG TVIVREGGKTVAKVPTLLIVKEPDYPRVTSVSVSEGSVQGTYQIETYLPAGAEELAFL VYDSNLDFAGQAGIYKNQDKGYQYFDWDGTINGGTKLPAGEYYLLAYAANKGKSSQVL TEEPFTVE*" /label="vpr CDS" gene 3288211..3290631 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /label="vpr gene" upshifts 3288369 /Source="Nicolas_upshifts" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3288378..3288397 /Source="Nicolas_upshift_promotors" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3290619 /Source="Nicolas_upshifts" /id="D1968" /incds=0 /nref=7 /ntot=104 /MaxReadThrough="0.60305" /MaxDrop="5.33856" /score="26.8487936" /energy="-16.5" /TU="NA" /idTUdmin="U2993" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3290669..3291670) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913069, 15774866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391689.1" /db_xref="EnsemblGenomes-Gn:BSU38100" /db_xref="EnsemblGenomes-Tr:CAB15836" /db_xref="GOA:P39606" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10590" /db_xref="UniProtKB/Swiss-Prot:P39606" /translation="MVSLSILDQSPVSEGSNAETALQQTVALAQAAEDLGYKRFWVSE HHFSKRLAGSSPEVLISHIAAKTKRIRVGSGGVMLPHYSAYKVAENFRVLEGLTPGRI DLGLGRAPGGMPIASWALNDGGKRNADQYPQQIKELTMYLHDLADDKHRFPNLTAAPH ISTAPDVWLLGSSGESALLAAESGAGYMFAHFINGEGGEGTVRQYKRRFKPSVLGDTP RAAVAVFVLCADTEEKAEELGAVLDFTLLAGEQGIPLEGVPSYEAVRKNTYSPYEQRR IADNRNRMIVGTKEQVKERLLALSNAYETEEIMVVTITHHFEDKLRSYRLLQEAFAD* " /label="ywcH CDS" gene complement(3290669..3291670) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /label="ywcH gene" S_feature complement(3291671..3291832) /Source="Nicolas_S_feature" /locus_tag="new_3911304_3911465_c" /HighExp="Etha, Diami, dia15, LPhT, dia5, H2O2, B60, LBGstat, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1468" CDS complement(3291844..3292593) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /EC_number="1.5.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-containing NADPH-linked nitro/flavin reductase" /protein_id="NP_391690.1" /db_xref="EnsemblGenomes-Gn:BSU38110" /db_xref="EnsemblGenomes-Tr:CAB15837" /db_xref="GOA:P39605" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:3N2S" /db_xref="SubtiList:BG10589" /db_xref="UniProtKB/Swiss-Prot:P39605" /translation="MNNTIETILNHRSIRSFTDQLLTAEEIDTLVKSAQAASTSSYVQ AYSIIGVSDPEKKRELSVLAGNQPYVEKNGHFFVFCADLYRHQQLAEEKGEHISELLE NTEMFMVSLIDAALAAQNMSIAAESMGLGICYIGGIRNELDKVTEVLQTPDHVLPLFG LAVGHPANLSGKKPRLPKQAVYHENTYNVNTDDFRHTMNTYDKTISDYYRERTNGKRE ETWSDQILNFMKQKPRTYLNDYVKEKGFNKN*" /label="nfrAA CDS" gene complement(3291844..3292593) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /label="nfrAA gene" downshifts complement(3291877) /Source="Nicolas_upshifts" /id="D1969" /incds=0 /nref=11 /ntot=191 /MaxReadThrough="5.92216" /MaxDrop="3.39651" /score="17.7447455" /energy="-9.9" /TU="U2995" /idTUdmin="U2996" /TUdmin=770 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3292611..3292630) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3292628) /Source="Nicolas_upshifts" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3292645..3292648) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3292699..3293880) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9622350, 15612918, 15849754, 16850406, 28085152" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 15612918, 15849754, 16850406, 28085152; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycosyltransferase involved in extension of thelateral walls of the cell" /protein_id="NP_391691.1" /db_xref="EnsemblGenomes-Gn:BSU38120" /db_xref="EnsemblGenomes-Tr:CAB15838" /db_xref="GOA:P39604" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10588" /db_xref="UniProtKB/Swiss-Prot:P39604" /translation="MSRYKKQQSPFYQGDLIFIFGVFFIISVVSIYAAGQFGQYGNTD WIQQIVFYLLGAVAITVLLYFDLEQLEKLSLYIFIIGILSLIILKISPESIAPVIKGA KSWFRIGRITIQPSEFMKVGLIMMLASVIGKANPKGVRTLRDDIHLLLKIAGVAVIPV GLILMQDAGTAGICMFIVLVMVFMSGINWKLIAIIAGSGILLISLILLVMINFPDVAK SVGIQDYQIKRVTSWVSASNETQEDSNDSWQVDQAIMAIGSGGILGNGISNLKVYVPE STTDFIFSIIGESFGFIGCAIVVIMFFFLIYRLVVLIDKIHPFNRFASFFCVGYTALI VIHTFQNIGMNIGIMPVTGIPLLFVSYGGSSTLSTLIGFGIVYNASVQLTKYRSYLFN S*" /label="rodA CDS" gene complement(3292699..3293880) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /label="rodA gene" downshifts complement(3292713) /Source="Nicolas_upshifts" /id="D1970" /incds=0 /nref=20 /ntot=124 /MaxReadThrough="3.38052" /MaxDrop="5.67563" /score="31.4805549" /energy="-13.3" /TU="U2996" /idTUdmin="U2996" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3293881..3294012) /Source="Nicolas_S_feature" /locus_tag="new_3913514_3913645_c" /HighExp="Heat, T0.30H, H2O2, T1.0H, Salt, Paraq, T1.30H, LBGstat, Oxctl, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1469" promotor_-10 complement(3294006..3294021) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-10" upshifts complement(3294012) /Source="Nicolas_upshifts" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="upshifts" promotor_-35 complement(3294033..3294042) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-35" promotor_-35 3294247..3294254 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3294265..3294375 /Source="Nicolas_S_feature" /locus_tag="new_3913898_3914008" /HighExp="M9-stat, T0.30H, T1.30H, T1.0H, T4.0H, T2.30H, T3.30H, T3.0H, T5.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1470" promotor_-10 3294265..3294284 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3294265 /Source="Nicolas_upshifts" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="upshifts" CDS 3294376..3294639 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16159778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159778; Product type f: factor" /codon_start=1 /transl_table=11 /product="holin-like protein required for proper spore morphogenesis and germination" /protein_id="NP_391692.1" /db_xref="EnsemblGenomes-Gn:BSU38130" /db_xref="EnsemblGenomes-Tr:CAB15839" /db_xref="GOA:P39603" /db_xref="InterPro:IPR020185" /db_xref="SubtiList:BG10587" /db_xref="UniProtKB/Swiss-Prot:P39603" /translation="MMDMFFAYLLVASATPLFIWLDNKKVALSAIPPIILMWVFFFFY ATESLSPLGHTLMIILFAVNVIVAHIAAFIIYGLPYLRRKRSS*" /label="ywcE CDS" gene 3294376..3294639 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /label="ywcE gene" downshifts 3294529 /Source="Nicolas_upshifts" /id="D1971" /incds=1 /nref=1 /ntot=99 /MaxReadThrough="6.85004" /MaxDrop="2.5697" /score="27.9247684" /energy="-11.4" /TU="U2997" /idTUdmin="U2997" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3294645 /Source="Nicolas_upshifts" /id="D1972" /incds=0 /nref=7 /ntot=90 /MaxReadThrough="2.04756" /MaxDrop="6.52141" /score="27.9247684" /energy="-11.4" /TU="NA" /idTUdmin="U2997" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3294682..3295056) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit IV)" /protein_id="NP_391693.1" /db_xref="EnsemblGenomes-Gn:BSU38140" /db_xref="EnsemblGenomes-Tr:CAB15840" /db_xref="GOA:P34959" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014250" /db_xref="SubtiList:BG10586" /db_xref="UniProtKB/Swiss-Prot:P34959" /translation="MANKSAEHSHFPWKHIVGFILSIVLTLLALWVAVYTDLSSSAKL WIIFGFAFIQAALQLLMFMHMTESENGTIQVGNTLFGFFGAIVIVLGSIWIFAAHYHH GDHMDGNPPGGAEHSEHSGHNE*" /label="qoxD CDS" gene complement(3294682..3295056) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /label="qoxD gene" downshifts complement(3294693) /Source="Nicolas_upshifts" /id="D1973" /incds=0 /nref=222 /ntot=267 /MaxReadThrough="2.42368" /MaxDrop="9.0593" /score="21.3154492" /energy="-11.4" /TU="NA" /idTUdmin="U3000" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3295058..3295672) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit III)" /protein_id="NP_391694.1" /db_xref="EnsemblGenomes-Gn:BSU38150" /db_xref="EnsemblGenomes-Tr:CAB15841" /db_xref="GOA:P34958" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR014246" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10585" /db_xref="UniProtKB/Swiss-Prot:P34958" /translation="MEHAEHGNSNAPMEYQSETGRLNILGFWIFLGAEIVLFSTLFAT FFVLKNRTAGGVLPDELFEVNLVMIMTFLLLISSFTCGIAVHEMRRGSLKGVVIWTII TLLLGAGFVGCEINEFVHYVHEGAALSTSAFWSGFFVLLGTHGTHVTIGIFWITGILI QLKKRGLTPQTSSKIFISSLYWHFLDVVWIFIFTGVYLMGLGGL*" /label="qoxC CDS" gene complement(3295058..3295672) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /label="qoxC gene" CDS complement(3295686..3297635) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit I)" /protein_id="NP_391695.1" /db_xref="EnsemblGenomes-Gn:BSU38160" /db_xref="EnsemblGenomes-Tr:CAB15842" /db_xref="GOA:P34956" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014233" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10584" /db_xref="UniProtKB/Swiss-Prot:P34956" /translation="MKFKWDEFFVTGDPLILGAQVSIALSTIAIIFVLTYFKKWKWLW SEWITTVDHKKLGIMYIISAVIMLFRGGVDGLMMRAQLALPNNSFLDSNHYNEIFTTH GTIMIIFMAMPFLIGLINVVVPLQIGARDVAFPYLNNLSFWTFFVGAMLFNISFVIGG SPNAGWTSYMPLASNDMSPGPGENYYLLGLQIAGIGTLMTGINFMVTILKMRTKGMTL MRMPMFTWTTLITMVIIVFAFPVLTVALALLSFDRLFGAHFFTLEAGGMPMLWANLFW IWGHPEVYIVILPAFGIFSEIISSFARKQLFGYKAMVGSIIAISVLSFLVWTHHFFTM GNSASVNSFFSITTMAISIPTGVKIFNWLFTMYKGRISFTTPMLWALAFIPNFVIGGV TGVMLAMAAADYQYHNTYFLVSHFHYVLIAGTVFACFAGFIFWYPKMFGHKLNERIGK WFFWIFMIGFNICFFPQYFLGLQGMPRRIYTYGPNDGWTTLNFISTVGAFMMGVGFLI LCYNIYYSFRYSTREISGDSWGVGRTLDWATSSAIPPHYNFAVLPEVKSQDAFLHMKE EKTELYPESKFKKIHMPSNSGRPFFMSVAFGLAGFGLVFEWYWMGVVGLIGVLLCMVL RSFEYDNGYYISVDEIKETERKISE*" /label="qoxB CDS" gene complement(3295686..3297635) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /label="qoxB gene" misc_feature 3296899..3296918 /Source="Nicolas_upshift_promotors" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3296905 /Source="Nicolas_upshifts" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3297329..3297429 /Source="Nicolas_upshift_promotors" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3297389 /Source="Nicolas_upshifts" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3297499 /Source="Nicolas_upshifts" /id="D1974" /incds=1 /nref=1 /ntot=73 /MaxReadThrough="3.07388" /MaxDrop="3.44223" /score="-7.14620582" /energy="-8.1" /TU="U2999" /idTUdmin="U2999" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" CDS complement(3297663..3298628) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 22720735, 26196462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit II)" /protein_id="NP_391696.2" /db_xref="EnsemblGenomes-Gn:BSU38170" /db_xref="EnsemblGenomes-Tr:CAB15843" /db_xref="GOA:P34957" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR006332" /db_xref="InterPro:IPR006333" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR034227" /db_xref="InterPro:IPR036257" /db_xref="SubtiList:BG10583" /db_xref="UniProtKB/Swiss-Prot:P34957" /translation="MIFLFRALKPLLVLALLTVVFVLGGCSNASVLDPKGPVAEQQSD LILLSIGFMLFIVGVVFVLFTIILVKYRDRKGKDNGSYNPEIHGNTFLEVVWTVIPIL IVIALSVPTVQTIYSLEKAPEATKDKEPLVVYATSVDWKWVFSYPEQDIETVNYLNIP VDRPILFKISSADSMASLWIPQLGGQKYAMAGMLMDQYLQADKVGTYEGRNANFTGEH FADQEFDVNAVTEKDFNSWVKKTQNEAPKLTKEKYDELMLPENVDELTFSSTHLKYVD HGQDAEYAMEARKRLGYQAVSPHSKTDPFENVKKNEFKKSDDTEE*" /label="qoxA CDS" gene complement(3297663..3298628) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /label="qoxA gene" S_feature complement(3298629..3298697) /Source="Nicolas_S_feature" /locus_tag="new_3918262_3918330_c" /HighExp="M0t90, M40t90, Lbtran, Lbstat, M40t45, S2, nit, ferm, LBGstat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="0.626, 1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1471" promotor_-10 complement(3298684..3298703) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3298697) /Source="Nicolas_upshifts" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3298699..3298884) /Source="Nicolas_S_feature" /locus_tag="new_3918332_3918517_c" /HighExp="LBGstat, Heat, G150, G135, LBGtran, G180, BMM, Salt, LBGexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1472" promotor_-35 complement(3298716..3298720) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3298815..3298820 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3298836..3298854 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3298841 /Source="Nicolas_upshifts" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3298875..3298894) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3298884) /Source="Nicolas_upshifts" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3298886..3298995) /Source="Nicolas_S_feature" /locus_tag="new_3918519_3918628_c" /HighExp="Heat, Salt, LBGstat, BMM, Oxctl, H2O2, MG 15, UNK1, MG-0.1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1473" promotor_-35 complement(3298909..3298913) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3298951 /Source="Nicolas_upshifts" /id="D1975" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.69533" /MaxDrop="4.01393" /score="13.5410442" /energy="-16.4" /TU="U3001" /idTUdmin="U3001" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3298980..3298999) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3298995) /Source="Nicolas_upshifts" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3299015..3299019) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3299073..3299091) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3299078..3299084 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3299090) /Source="Nicolas_upshifts" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3299099..3299117 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3299102 /Source="Nicolas_upshifts" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3299107..3299112) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3299144..3299389 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391697.2" /db_xref="EnsemblGenomes-Gn:BSU38180" /db_xref="EnsemblGenomes-Tr:CAB15844" /db_xref="GOA:O32282" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG14162" /db_xref="UniProtKB/Swiss-Prot:O32282" /translation="MSFLISLIVAIIIGWLGSLFVKGDMPGGIIGSMIAGLIGAWIGH GLLGTWGPHLAGFAIIPAVIGAAIVVFLVSLLTRKRG*" /label="ywzA CDS" gene 3299144..3299389 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /label="ywzA gene" downshifts 3299371 /Source="Nicolas_upshifts" /id="D1976" /incds=0 /nref=125 /ntot=189 /MaxReadThrough="2.63086" /MaxDrop="7.72876" /score="13.5410442" /energy="-16.4" /TU="NA" /idTUdmin="U3005" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3299460..3301001) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /EC_number="2.7.7.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917, 11790749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917, 11790749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactose-1-phosphate uridyltransferase" /protein_id="NP_391698.2" /db_xref="EnsemblGenomes-Gn:BSU38190" /db_xref="EnsemblGenomes-Tr:CAB15845" /db_xref="GOA:P39575" /db_xref="InterPro:IPR000766" /db_xref="InterPro:IPR005849" /db_xref="InterPro:IPR005850" /db_xref="InterPro:IPR023425" /db_xref="SubtiList:BG10582" /db_xref="UniProtKB/Swiss-Prot:P39575" /translation="MSIIEHLEQLLEYGLERKLISIWDREYTRNRLYEALGITHPEPN SSTSIKQSQSLPDLLAPIYKWAAETGRMEADTDTYRDLLSAKLMGCFVPAPSEVIRKF EETKALYGPKQATKEFYQYSEDVYYIRTDRIAKNVHWTVPTEYGELEMTINLSKPEKD PKAIAAAKEQEQTNYPMCLLCKENVGFEGSVNHPARQNHRIIPVILEDEQWFLQFSPY VYYPEHCIVLKGEHEPMEISKKTFERLLSFLGQYPHYFIGSNADLPIVGGSILSHDHF QGGAHDFPMARAEAEDVYELNDYPGVSLGLVKWPMSVLRLQGDEPGHVAEAADHIFRT WQTYSDEKAGIAAYTGDTPHNTVTPIARRRGDLYELDIVLRNNRTDEEHPLGIFHPHQ EVHHIKKENIGLIEVMGLAILPGRLQEEMKETAAALCSADPKTALEQNPLTAKHSEWA LRTMEKRTITKENVDLVIKEELGHVFARILEHAGVFKQTAEGKQAFRRFIDQLGAKPV KSLNR*" /label="galT CDS" gene complement(3299460..3301001) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /label="galT gene" downshifts complement(3299489) /Source="Nicolas_upshifts" /id="D1977" /incds=0 /nref=190 /ntot=254 /MaxReadThrough="0.3431" /MaxDrop="6.63153" /score="21.0691542" /energy="-14.7" /TU="NA" /idTUdmin="U3006" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3301005..3302177) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /EC_number="2.7.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactokinase" /protein_id="NP_391699.1" /db_xref="EnsemblGenomes-Gn:BSU38200" /db_xref="EnsemblGenomes-Tr:CAB15846" /db_xref="GOA:P39574" /db_xref="InterPro:IPR000705" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR006206" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR019539" /db_xref="InterPro:IPR019741" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022963" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10581" /db_xref="UniProtKB/Swiss-Prot:P39574" /translation="MREELKGIFASVFGEKEGLRFFFAPGRVNLIGEHTDYNGGHVFP CALTMGTYAAVAERNDGLVRMYSDNFRNAGIKECSLDDIRYQKEDDWANYPKGVIYEF QQRGYAVPHGFDIVFSGNIPNGAGLSSSASIELLMGVVLQSYFHPEVDALELVKMAQH AENHFIGVNCGIMDQFAIGMGKKHHAMLLNCDTLDYEYSKLNVSGLALVIANTNKKRT LADSSYNTRRQECNDALLDLKKGLDIAALGDIKPSDFDAHSSLIQNETNRRRAKHAVY ENHRAIKTAHMFKENNIDEIGQLMKESHLSLKDDYEVTCPELDELVFAAWDHEGVIGS RMTGAGFGGCTISIVKDEFVDDFIQKVGDRYQEKTGLRADFYVADIGEGARELKGE*" /label="galK CDS" gene complement(3301005..3302177) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /label="galK gene" promotor_-10 complement(3302195..3302213) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3302217) /Source="Nicolas_upshifts" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3302228..3302234) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3302258..3302641) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882654, 15849754, 16850406, 18192405; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall glycosylation protein" /protein_id="NP_391700.1" /db_xref="EnsemblGenomes-Gn:BSU38210" /db_xref="EnsemblGenomes-Tr:CAB15847" /db_xref="GOA:P39602" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG10580" /db_xref="UniProtKB/Swiss-Prot:P39602" /translation="MYIIMGVFTTIVNIASFYILVEIMNVDYKAATVAAWILSVLFAY ITNKLYVFQQKTHDLQSLLKELTAFFSVRVLSLGIDLGMMIILVGQFNTNETLAKILD NAVIVVVNYVASKWLVFKKTKEEGV*" /label="ywcD CDS" gene complement(3302258..3302641) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /label="ywcD gene" CDS complement(3302659..3303330) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of slrA (biofilm formation)" /protein_id="NP_391701.2" /db_xref="EnsemblGenomes-Gn:BSU38220" /db_xref="EnsemblGenomes-Tr:CAB15848" /db_xref="GOA:P39601" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10579" /db_xref="UniProtKB/Swiss-Prot:P39601" /translation="MKKNKFQIKREATFESFIDAGVNLLIDRAYDPVSVEDISRAAGY SKGAFYVHFVSKDDFLLYLLEKRQMKKKIIIGYLDQMERESVKSLTLDEAAKHAAELL YSYYINKPSWDITSFAMNMPTYKVLKKCKAYVRLYELWVEENVLYIKWLKERKLIDAC IDPEYTAKIICAVLDGIIKQSYVLGQPATFRSFLDALSVFFTLDREHERPRILKSFSE SEEHQ*" /label="slrC CDS" gene complement(3302659..3303330) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /label="slrC gene" promotor_-10 complement(3303352..3303371) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3303361) /Source="Nicolas_upshifts" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3303387..3303390) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3303471..3303474 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3303489..3303508 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3303498..3303685 /Source="Nicolas_S_feature" /locus_tag="new_3923131_3923318" /HighExp="T0.30H, T1.0H, Cold, T1.30H, HiOs, T-0.40H, T2.0H, T2.30H, T4.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1474" upshifts 3303498 /Source="Nicolas_upshifts" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="upshifts" CDS 3303686..3303844 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168, 26857544" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168, 26857544; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-repressor of SlrR" /protein_id="YP_003097794.1" /db_xref="EnsemblGenomes-Gn:BSU38229" /db_xref="EnsemblGenomes-Tr:CAX52707" /db_xref="GOA:P0C8M5" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="UniProtKB/Swiss-Prot:P0C8M5" /translation="MKTHVKKDLDKGWHMLIQEARSIGLGIHDVRQFLESETASRKKN HKKTVRQD*" /label="slrA CDS" gene 3303686..3303844 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /label="slrA gene" S_feature 3303845..3304229 /Source="Nicolas_S_feature" /locus_tag="new_3923478_3923862" /HighExp="T0.30H, Cold, T1.30H, T2.0H, T1.0H, HiOs, T2.30H, T3.0H, LBGstat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1475" promotor_-35 3304210..3304215 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3304231..3304249 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3304231 /Source="Nicolas_upshifts" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="upshifts" CDS 3304287..3304595 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of acetate transporter as a volatile signal for biofilm formation" /protein_id="NP_391702.1" /db_xref="EnsemblGenomes-Gn:BSU38230" /db_xref="EnsemblGenomes-Tr:CAB15849" /db_xref="GOA:P39600" /db_xref="InterPro:IPR007436" /db_xref="SubtiList:BG10578" /db_xref="UniProtKB/Swiss-Prot:P39600" /translation="MYKADYKQIAATPSFQAFLKQKRAFIVPSAIFFFVFYFSLPVLT SYFTFLNAPAIGAVSWAWLFAIAQFAMTWILSTVYSRRAAHFDKYVSALKEDLKGEQT *" /label="vbfB CDS" gene 3304287..3304595 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /label="vbfB gene" downshifts complement(3304373) /Source="Nicolas_upshifts" /id="D1978" /incds=1 /nref=3 /ntot=15 /MaxReadThrough="0.42282" /MaxDrop="5.4957" /score="10.1452497" /energy="-8.3" /TU="NA" /idTUdmin="U3010" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3304377..3304477) /Source="Nicolas_upshift_promotors" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3304417) /Source="Nicolas_upshifts" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3304592..3306133 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="acetate Na+-dependent symporter subunit involvedin volatile signal for biofilm formation" /protein_id="NP_391703.2" /db_xref="EnsemblGenomes-Gn:BSU38240" /db_xref="EnsemblGenomes-Tr:CAB15850" /db_xref="GOA:P39599" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG10577" /db_xref="UniProtKB/Swiss-Prot:P39599" /translation="MNMTAFLLFLAIVGLTLIITYFAAKRTKTTSEFYTAGGGLTGVQ NGLAIAGDYMSAASFLGIAGMIALYGFDGFFYSIGFLVAYLVVLYIVAEPLRNLGKYT MADMIAARFKEKKIRGVAALNTIAISTFYMIAQLVGAGALIKLLLGLDYTAAVLIVGV LMTIYVVFGGMIATSWVQIIKAVLLMAGTLVISIIVFSKFGFSLNTMFEQMKTATPLG ADFLNPGNKYKVPLETLSLNLALVLGTAGLPHILIRFYTVKDAKTARTSVVSATWIIG VFYIMTVFLGFGAAAFVGFDAITAADQAGNMAAPLLAKALGGDFLFAFVSAIAFATIL AVVTGLVLSAASAFAHDIYSQIIRKGEATEKEQMKAARWASVAVSVLSILLAIFAQSL NVAFLVALAFAVAASANLPLIVFTVFWKRFNASGALWGSLTGLISALVLVSMSPSVWD PAGGAIFTGDPLIPLSNPGIISIPLGFLGAWLGTVLSSDKTIDEDTFAEIQVKAHTGV HMEQE*" /label="vbfA CDS" gene 3304592..3306133 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /label="vbfA gene" downshifts 3306124 /Source="Nicolas_upshifts" /id="D1979" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="2.40129" /MaxDrop="4.15104" /score="2.66606932" /energy="-7.8" /TU="NA" /idTUdmin="U3009" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3306164..3306766) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reductase" /protein_id="NP_391704.1" /db_xref="EnsemblGenomes-Gn:BSU38250" /db_xref="EnsemblGenomes-Tr:CAB15851" /db_xref="GOA:P39598" /db_xref="InterPro:IPR001853" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10576" /db_xref="UniProtKB/Swiss-Prot:P39598" /translation="MTVHIKVYSDYVCPFCFVGKAAFEEAIKGKDVEVEWMPFELRPS PSPQLDPVNDPSKQYMWQTSIQPMAEKLGVEINFPNVSPHPYTDLAFEGFHFAKEYNK GHEYNTRVFQAFFQEDQNIGDIDILTKLAEEVGLDGASFKSALETRTYQDVQRQALKH AYEEADITAVPTFIIGDTVIPGAAGKDVFEKAISDEQKKK*" /label="ywbO CDS" gene complement(3306164..3306766) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /label="ywbO gene" downshifts complement(3306178) /Source="Nicolas_upshifts" /id="D1980" /incds=0 /nref=12 /ntot=123 /MaxReadThrough="1.89374" /MaxDrop="3.51247" /score="21.9354981" /energy="-7.8" /TU="NA" /idTUdmin="U3011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3306767..3307048) /Source="Nicolas_S_feature" /locus_tag="new_3926400_3926681_c" /HighExp="T1.0H, G135, G150, T1.30H, Lbexp, G180, Lbstat, dia5, LBGexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.984, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1476" CDS complement(3307049..3308299) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /EC_number="1.11.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxidase converting ferric iron into ferrous iron" /protein_id="NP_391705.1" /db_xref="EnsemblGenomes-Gn:BSU38260" /db_xref="EnsemblGenomes-Tr:CAB15852" /db_xref="GOA:P39597" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR006313" /db_xref="InterPro:IPR006314" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019546" /db_xref="SubtiList:BG10575" /db_xref="UniProtKB/Swiss-Prot:P39597" /translation="MSDEQKKPEQIHRRDILKWGAMAGAAVAIGASGLGGLAPLVQTA AKPSKKDEKEEEQIVPFYGKHQAGITTAHQTYVYFAALDVTAKDKSDIITLFRNWTSL TQMLTSGKKMSAEQRNQYLPPQDTGESADLSPSNLTVTFGFGPGFFEKDGKDRFGLKS KKPKHLAALPAMPNDNLDEKQGGGDICIQVCADDEQVAFHALRNLLNQAVGTCEVRFV NKGFLSGGKNGETPRNLFGFKDGTGNQSTKDDTLMNSIVWIQSGEPDWMTGGTYMAFR KIKMFLEVWDRSSLKDQEDTFGRRKSSGAPFGQKKETDPVKLNQIPSNSHVSLAKSTG KQILRRAFSYTEGLDPKTGYMDAGLLFISFQKNPDNQFIPMLKALSAKDALNEYTQTI GSALYACPGGCKKGEYIAQRLLES*" /label="efeB CDS" gene complement(3307049..3308299) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /label="efeB gene" downshifts complement(3307145) /Source="Nicolas_upshifts" /id="D1981" /incds=1 /nref=67 /ntot=232 /MaxReadThrough="5.0552" /MaxDrop="3.65898" /score="21.9354981" /energy="-7.8" /TU="U3011,U3012" /idTUdmin="U3011" /TUdmin="-967" /isTUend="FALSE" /label="downshifts" CDS complement(3308318..3309475) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipoprotein binding ferrous or ferric iron for transport" /protein_id="NP_391706.1" /db_xref="EnsemblGenomes-Gn:BSU38270" /db_xref="EnsemblGenomes-Tr:CAB15853" /db_xref="GOA:P39596" /db_xref="InterPro:IPR018976" /db_xref="InterPro:IPR034981" /db_xref="SubtiList:BG10574" /db_xref="UniProtKB/Swiss-Prot:P39596" /translation="MNFTKIAVSAGCILALCAGCGANDTSSTKEKASSEKSGVTKEIT ASVNKMETIISKLNDSVEKGDQKEIEKKGKELNSYWLSFENDIRSDYPFEYTEIEKHL QPIYTEAQKDKPDAGKIKTESESLKASLEDLTEAKKSGKKASDQLAKAADEYKGYVKE QSDQLVKATEAFTGAVKSGDIEKSKTLYAKARVYYERIEPIAESLGDLDPKIDAREND VEEGDKWTGFHKLEKAIWKDQDISGEKATADQLLKDVKELDGSIQSLKLTPEQIVAGA MELLNEAGISKITGEEERYSRIDLVDLMANVEGSEAVYQTVKSALVKDHSDLTEKLDT EFSEFEVLMAKYKTNDQSYTSYDKLSEKQIRELSTKLTTLSETMSKIANVL*" /label="efeM CDS" gene complement(3308318..3309475) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /label="efeM gene" misc_feature complement(3308391..3308410) /Source="Nicolas_upshift_promotors" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3308418) /Source="Nicolas_upshifts" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3309472..3310917) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrous ion permease" /protein_id="NP_391707.2" /db_xref="EnsemblGenomes-Gn:BSU38280" /db_xref="EnsemblGenomes-Tr:CAB15854" /db_xref="GOA:P39595" /db_xref="InterPro:IPR004923" /db_xref="SubtiList:BG10573" /db_xref="UniProtKB/Swiss-Prot:P39595" /translation="MARGLALILFSLLMVFGSAAHAEDDPIAALIQLNKQMIKSVKDG DMDSAQQTFDTFKAKWKKEEPSIKKENLSSHSEMDANIAMISLSFINQDARKLKTQLE ELASHLETYQQAVVLKKTSSGQSRASLTAYIQSLKDTKQFIEKKQLDEASSAIDNLVT SWLAVEGDVVSQSKEAYTTSEENLALMKAEIGSHPEKVSKQIDEMIQLLEPIASSSYS WWDAALIPVREGMEALLVIGALLTMTKKARVTRSSTWIWGGASAGMAVSLAAGIGVTV LFSSSVFGENNFLLGGVTGVLSAVMLLYVGVWLHRNASMDKWREKINIQKSQALKKRS LLSFALIAFLAVVREGLETVIFFIGLVGKLPLTELIGGTAAGLIVLVIVGVLMIKLGM RIPLKPFFLLSMAVVLYMCVKFLGTGVHSLQLAGILPSDAESWLPSVSVLGIYPSVYS TIPQMLILLFLLIALVSEAAKHFTNGKELTK*" /label="efeU CDS" gene complement(3309472..3310917) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /label="efeU gene" promotor_-10 complement(3310951..3310970) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3310961) /Source="Nicolas_upshifts" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3310984..3310991) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3311074..3311742) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /EC_number="2.5.1.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10382260, 16291685, 19888457, 22616866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-phosphate pyrophosphorylase (thiamine phosphate synthase)" /protein_id="NP_391708.1" /db_xref="EnsemblGenomes-Gn:BSU38290" /db_xref="EnsemblGenomes-Tr:CAB15855" /db_xref="GOA:P39594" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR034291" /db_xref="InterPro:IPR036206" /db_xref="PDB:1G4E" /db_xref="PDB:1G4P" /db_xref="PDB:1G4S" /db_xref="PDB:1G4T" /db_xref="PDB:1G67" /db_xref="PDB:1G69" /db_xref="PDB:1G6C" /db_xref="PDB:2TPS" /db_xref="PDB:3O15" /db_xref="PDB:3O16" /db_xref="SubtiList:BG10572" /db_xref="UniProtKB/Swiss-Prot:P39594" /translation="MTRISREMMKELLSVYFIMGSNNTKADPVTVVQKALKGGATLYQ FREKGGDALTGEARIKFAEKAQAACREAGVPFIVNDDVELALNLKADGIHIGQEDANA KEVRAAIGDMILGVSAHTMSEVKQAEEDGADYVGLGPIYPTETKKDTRAVQGVSLIEA VRRQGISIPIVGIGGITIDNAAPVIQAGADGVSMISAISQAEDPESAARKFREEIQTY KTGR*" /label="thiE CDS" gene complement(3311074..3311742) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /label="thiE gene" downshifts complement(3311083) /Source="Nicolas_upshifts" /id="D1982" /incds=0 /nref=44 /ntot=194 /MaxReadThrough="1.62789" /MaxDrop="4.13196" /score="10.8502035" /energy="-10" /TU="NA" /idTUdmin="U3013" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3311739..3312557) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /EC_number="2.7.1.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10382260, 16291685, 22938038, 28729425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10382260, 16291685, 22938038, 28729425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-(2-hydroxyethyl)-4-methylthiazole kinase" /protein_id="NP_391709.1" /db_xref="EnsemblGenomes-Gn:BSU38300" /db_xref="EnsemblGenomes-Tr:CAB15856" /db_xref="GOA:P39593" /db_xref="InterPro:IPR000417" /db_xref="InterPro:IPR029056" /db_xref="PDB:1C3Q" /db_xref="PDB:1EKK" /db_xref="PDB:1EKQ" /db_xref="PDB:1ESJ" /db_xref="PDB:1ESQ" /db_xref="SubtiList:BG10571" /db_xref="UniProtKB/Swiss-Prot:P39593" /translation="MDAQSAAKCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPV MAYAKEEVADMAKIAGALVLNIGTLSKESVEAMIIAGKSANEHGVPVILDPVGAGATP FRTESARDIIREVRLAAIRGNAAEIAHTVGVTDWLIKGVDAGEGGGDIIRLAQQAAQK LNTVIAITGEVDVIADTSHVYTLHNGHKLLTKVTGAGCLLTSVVGAFCAVEENPLFAA IAAISSYGVAAQLAAQQTADKGPGSFQIELLNKLSTVTEQDVQEWATIERVTVS*" /label="thiM CDS" gene complement(3311739..3312557) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /label="thiM gene" CDS complement(3312565..3313470) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23504016; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family, cidAB expression)" /protein_id="NP_391710.1" /db_xref="EnsemblGenomes-Gn:BSU38310" /db_xref="EnsemblGenomes-Tr:CAB15857" /db_xref="GOA:P39592" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10570" /db_xref="UniProtKB/Swiss-Prot:P39592" /translation="MDIRHLTYFLEVARLKSFTKASQSLYVSQPTISKMIKNLEEELG IELFYRNGRQVELTDAGHSMYVQAQEIIKSFQNLTSELNDIMEVKKGHVRIGLPPMIG SGFFPRVLGDFRENYPNVTFQLVEDGSIKVQEGVGDGSLDIGVVVLPANEDIFHSFTI VKETLMLVVHPSHRLADEKECQLRELKDEPFIFFREDFVLHNRIMTECIKAGFRPHII YETSQWDFISEMVSANLGIGLLPERICRGLDPEKVKVIPLVDPVIPWHLAIIWRKDRY LSFAARAWLEHTKSYLWDPKKDSKG*" /label="cidR CDS" gene complement(3312565..3313470) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /label="cidR gene" misc_feature complement(3313205..3313224) /Source="Nicolas_upshift_promotors" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3313216) /Source="Nicolas_upshifts" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3313511..3313530) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3313521..3313528 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3313532) /Source="Nicolas_upshifts" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" upshifts 3313540 /Source="Nicolas_upshifts" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3313542..3313561 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3313546..3313553) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3313576..3313962 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 22383849, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator of murein hydrolases" /protein_id="NP_391711.1" /db_xref="EnsemblGenomes-Gn:BSU38320" /db_xref="EnsemblGenomes-Tr:CAB15858" /db_xref="GOA:P39591" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023760" /db_xref="SubtiList:BG10569" /db_xref="UniProtKB/Swiss-Prot:P39591" /translation="MKKLLLTVIQIALLFIFARLINWVTALLHINIPGSIIGIVILFT LLHFNIIKLEWIELGAAWLLGELLLFFIPSAVGVIEYGDIMSKFGVSILLVVIISTFV VMVSTGTLTQLIAKRKEKKHTCSSEL*" /label="cidA CDS" gene 3313576..3313962 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /label="cidA gene" CDS 3313944..3314621 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator controlling activity of murein hydrolases" /protein_id="NP_391712.2" /db_xref="EnsemblGenomes-Gn:BSU38330" /db_xref="EnsemblGenomes-Tr:CAB15859" /db_xref="GOA:P39590" /db_xref="InterPro:IPR005261" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG10568" /db_xref="UniProtKB/Swiss-Prot:P39590" /translation="MFIGIVSLFLTVLVYLGAKKVYQRFPRVYTSPLLVTPAVLVGLL LLVNVPYESYNLGGGLLTDMLQPATVAFAIPLYKYFPVLKKYAVEIILNVAVGSCIAI ISTALIAKWLHLGTGLIDSLVPRSVTTPIAMNVSEMIGGMPAVTAVFVILTALLGTVI GPMVIRYFRIDNEIARGVLLGTSAHGAGTSKAFELSSVSGTISSVSMILAAIMTLCAA PFLLSFM*" /label="cidB CDS" gene 3313944..3314621 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /label="cidB gene" downshifts 3314593 /Source="Nicolas_upshifts" /id="D1983" /incds=0 /nref=13 /ntot=88 /MaxReadThrough="2.20109" /MaxDrop="4.23919" /score="27.0474383" /energy="-8" /TU="NA" /idTUdmin="U3015" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3314665..3314672 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3314683 /Source="Nicolas_upshifts" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3314686..3314705 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3314725..3315924 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar permease" /protein_id="NP_391713.1" /db_xref="EnsemblGenomes-Gn:BSU38340" /db_xref="EnsemblGenomes-Tr:CAB15860" /db_xref="GOA:P39589" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024989" /db_xref="InterPro:IPR026032" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10567" /db_xref="UniProtKB/Swiss-Prot:P39589" /translation="MHNLQVRRHYAALKGFYLFAFLGTGSIIPLLSMYLTKEQHLSGS QVGLIMSLGPIVMIFFQPFWGMLSDYTQKTKGLLAVCTSITGIIGLAYIAFDSFPLFI LIAACFAAFQSTIIPLSDSISLRYTQETNGNYGGIRLFGSLGFGVAVFAMGQVTNQLY PIHVIFIFGCAFLCIAAILASQVPGQQKTTKVNIRKGFRELISNKTFLIFMIITFTTF APNLANNTYFSLFLDKSGASLSAIGILFFIGVISEIPFMRFAQTFIDKMGLLNVIMLS GGVSLFRWALYFTAPSLWIIYATVFLQGVAIGLFIPAALQYVKKITPRHVEATALTMY AAIGNGFGNWFCTFAGGYIFDYVSIFAVYLLFGILSIAGFGLTLYLMKAEKNKHTLHQ PAVTFKP*" /label="ywbF CDS" gene 3314725..3315924 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /label="ywbF gene" CDS 3315958..3316155 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391714.1" /db_xref="EnsemblGenomes-Gn:BSU38350" /db_xref="EnsemblGenomes-Tr:CAB15861" /db_xref="InterPro:IPR019240" /db_xref="SubtiList:BG10566" /db_xref="UniProtKB/Swiss-Prot:P39588" /translation="MNGQERNSISKGLQVDIVLKADQKTGKLTRGTVKDILTKSNFHP HGIKVRLEDGRIGRDQQIVST*" /label="ywbE CDS" gene 3315958..3316155 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /label="ywbE gene" downshifts 3316134 /Source="Nicolas_upshifts" /id="D1984" /incds=0 /nref=15 /ntot=205 /MaxReadThrough="1.90583" /MaxDrop="4.20528" /score="21.8132292" /energy="-12.2" /TU="NA" /idTUdmin="U3016" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(3316190..3317380) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18786544, 18789337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="large subunit ribosomal RNA m5C1962 methyltransferase" /protein_id="NP_391715.1" /db_xref="EnsemblGenomes-Gn:BSU38360" /db_xref="EnsemblGenomes-Tr:CAB15862" /db_xref="GOA:P39587" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019614" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10565" /db_xref="UniProtKB/Swiss-Prot:P39587" /translation="MKLLTLKKAHAAKIKKGYPLIEKEALAGSAGHMKEGDLVDIVSE SGGEFLARGYYGLQNKGVGWTLTRNKHEQIDQAFFLSKLTKAAQARAKLFEAQDTTAF RLFNGEGDGVGGVTIDYYDGYLLIQWYSKGIYTFKDMLISALDEMDLDYKAIYEKKRF DTAGQYVEDDDFVKGRRGEFPIIIQENGIQYAVDLNEGAMTGIFLDQRHVRKAIRDRY AKGKTVLNTFSYTGAFSVAAALGGAEKTTSVDVANRSLAKTIEQFSVNKLDYEAHDIK VMDVFNYFSYAAKKDLRFDLIILDPPSFARTKKRTFSAAKDYKNLLKETIAITADKGV IVASTNSSAFGMKKFKGFIDAAFKETNERYTIIEEFTLPEDFKTISAFPEGNYLKVVL LQKK*" /label="rlmI CDS" gene complement(3316190..3317380) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /label="rlmI gene" downshifts complement(3316205) /Source="Nicolas_upshifts" /id="D1985" /incds=0 /nref=5 /ntot=127 /MaxReadThrough="0.0525399999999996" /MaxDrop="4.51664" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin=71 /isTUend="FALSE" /label="downshifts" downshifts complement(3316289) /Source="Nicolas_upshifts" /id="D1986" /incds=1 /nref=42 /ntot=233 /MaxReadThrough="2.99734" /MaxDrop="3.89369" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" misc_feature complement(3317404..3317423) /Source="Nicolas_upshift_promotors" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3317420) /Source="Nicolas_upshifts" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3317440..3317447 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3317456 /Source="Nicolas_upshifts" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3317461..3317480 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3317501..3317881 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24330391, 25283443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391, 25283443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase I; hemithioacetal-bacillithiol lactoyl-bacillithiol formation" /protein_id="NP_391716.1" /db_xref="EnsemblGenomes-Gn:BSU38370" /db_xref="EnsemblGenomes-Tr:CAB15863" /db_xref="GOA:P39586" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10564" /db_xref="UniProtKB/Swiss-Prot:P39586" /translation="MAKRIDHTGIMVRDINASITFYEEVLGMKLKDRITHTNGVIELA FLGFEDGPETEIELIQGYSSELPAEGKVHHIALLTDDIAAEYTKAEKMNAKFIDEEIT TLPNGYRYFYIEGPDGEWIEFFQR*" /label="glxA CDS" gene 3317501..3317881 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /label="glxA gene" downshifts 3317779 /Source="Nicolas_upshifts" /id="D1987" /incds=1 /nref=14 /ntot=215 /MaxReadThrough="3.76076" /MaxDrop="3.68951" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-357" /isTUend="FALSE" /label="downshifts" downshifts 3317850 /Source="Nicolas_upshifts" /id="D1988" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="3.05249" /MaxDrop="3.56101" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" CDS complement(3317919..3318596) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391717.1" /db_xref="EnsemblGenomes-Gn:BSU38380" /db_xref="EnsemblGenomes-Tr:CAB15864" /db_xref="InterPro:IPR024250" /db_xref="SubtiList:BG10563" /db_xref="UniProtKB/Swiss-Prot:P39585" /translation="MLDYIWLDDESPILQQVPVEYSSAALIFSPFIQMPEGWENAKRK NDYEHIYPNDNEIRGIGKAVSWKKVMSSCGFQTHAELALALMTSIGALRDEFAREDLA EVLHENINGDLYYPSEDHISNFHIPSLVKVLGANGSNRFYYAEPIVENRGVLDITEAN LRTVLDEAATELVLTDEKMDFVFMSVYDSFINVFLAKDKNIHELVERMGWEAMICDES TYISWYR*" /label="ywbB CDS" gene complement(3317919..3318596) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /label="ywbB gene" downshifts complement(3317926) /Source="Nicolas_upshifts" /id="D1989" /incds=0 /nref=6 /ntot=156 /MaxReadThrough="0.15283" /MaxDrop="5.41362" /score="0.491291944" /energy="-11.7" /TU="NA" /idTUdmin="U3020" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3318605..3318624) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3318630) /Source="Nicolas_upshifts" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3318636..3318642) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3318673..3320007) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8990303, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cellobiose phosphotransferase system enzyme IIC permease component" /protein_id="NP_391718.1" /db_xref="EnsemblGenomes-Gn:BSU38390" /db_xref="EnsemblGenomes-Tr:CAB15865" /db_xref="GOA:P39584" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG10562" /db_xref="UniProtKB/Swiss-Prot:P39584" /translation="MSTFTRVMEEKIMPVAGKIAGQRHLSALRDGIILTMPLIIIGSV FLILTSLPIPGYADFMASVFGNEWADKLGYPVNASFDIMAMIAAFGIAYRLAESYGVD ALSAGAISIAAFLLATPFEVPFTPHGSTESIMVGGGIPITLLGSKGLFVAMLIALFST EIYRYIIQKNIVFKMPDGVPPAVSKSFVALIPGFIIVLLVWLARLLIEMTPFQSLHNV VGDLLGTPLSILGGSLGGSLIAEFVQMLLWSCGIHGASIIGGIMAPIWYGAMDANRLA FQAGEALPSIFTTQFFQIWINVGGSGATLALVLTMLVRSRSKQMKQLGRLGIGPALFN INEPIIFGMPIVMNPLLIVPFIIAPLLTITATYIGMSTGLVARPAGIAVPWTMPPLIS GYLATGGKVSGAVMQLVNLLITCAIYYPFFRIWDHQKWREESAVESGDKNVM*" /label="ywbA CDS" gene complement(3318673..3320007) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /label="ywbA gene" misc_feature complement(3320055..3320073) /Source="Nicolas_upshift_promotors" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3320078) /Source="Nicolas_upshifts" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3320172..3320179 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3320184 /Source="Nicolas_upshifts" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3320193..3320211 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3320235..3322172 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391719.1" /db_xref="EnsemblGenomes-Gn:BSU38400" /db_xref="EnsemblGenomes-Tr:CAB15866" /db_xref="GOA:P16396" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10561" /db_xref="UniProtKB/Swiss-Prot:P16396" /translation="MKNMSCKLVVSVTLFFSFLTIGPLAHAQNSSEKEVIVVYKNKAG KETILDSDADVEQQYKHLPAVAVTADQETVKELKQDPDILYVENNVSFTAADSTDFKV LSDGTDTSDNFEQWNLEPIQVKQAWKAGLTGKNIKIAVIDSGISPHDDLSIAGGYSAV SYTSSYKDDNGHGTHVAGIIGAKHNGYGIDGIAPEAQIYAVKALDQNGSGDLQSLLQG IDWSIANRMDIVNMSLGTTSDSKILHDAVNKAYEQGVLLVAASGNDGNGKPVNYPAAY SSVVAVSATNEKNQLASFSTTGDEVEFSAPGTNITSTYLNQYYATGSGTSQATPHAAA MFALLKQRDPAETNVQLREEMRKNIVDLGTAGRDQQFGYGLIQYKAQATDSAYAAAEQ AVKKAEQTKAQIDINKARELISQLPNSDAKTALHKRLDKVQSYRNVKDAKDKVAKAEK YKTQQTVDTAQTAINKLPNGTDKKNLQKRLDQVKRYIASKQAKDKVAKAEKSKKKTDV DSAQSAIGKLPASSEKTSLQKRLNKVKSTNLKTAQQSVSAAEKKSTDANAAKAQSAVN QLQAGKDKTALQKRLDKVKKKVAAAEAKKVETAKAKVKKAEKDKTKKSKTSAQSAVNQ LKASNEKTKLQKRLNAVKPKK*" /label="epr CDS" gene 3320235..3322172 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /label="epr gene" promotor_-10 complement(3321379..3321398) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3321380) /Source="Nicolas_upshifts" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3321412..3321420) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3322162 /Source="Nicolas_upshifts" /id="D1990" /incds=0 /nref=175 /ntot=224 /MaxReadThrough="1.26567" /MaxDrop="6.00181" /score="15.6173594" /energy="-13" /TU="NA" /idTUdmin="U3021" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3322275..3322282 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3322297..3322316 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3322316 /Source="Nicolas_upshifts" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3322528..3322535 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3322548..3322567 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3322548 /Source="Nicolas_upshifts" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="upshifts" CDS 3322600..3323979 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11580842, 1400159, 8535520, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11580842, 1400159, 8535520, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of SacY" /protein_id="NP_391720.1" /db_xref="EnsemblGenomes-Gn:BSU38410" /db_xref="EnsemblGenomes-Tr:CAB15867" /db_xref="GOA:P15400" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10560" /db_xref="UniProtKB/Swiss-Prot:P15400" /translation="MHKEIAKELLLLAGGKNNIISISHCTTRLRFDVKDETKIDIHAI ENLQGVQGTFFRYGLFQIIFGAGVVNKIYKEVVHVWETAPSEEPVHQKKASRKLNPAA AFAKTLSDIFVPIIPAITASGLLMGLIGMIKVFHWFAAGSPWIKMLDLVSSTAFILLP ILVGFSAARQFGSNPYLGAVIAGLLTHPDLLDPSMLGSKTPSSLDIWGLHIPMMGYQG SMIPILLSVFVMSKIEKLLKSIVPKSLDVVIIPFITVMVTGCLALIVMNPAASIIGQI MTQSIVYIYDHAGIAAGALFGGIYSTIVLSGLHHSFYAIEATLLANPHVGVNFLVPIW SMANVAQGGAGLAVFLKTKQSSLKKIALPASLTAFLGIVEPIVFGVNLKLIRPFIGAA IGGAIGGAYVVAVQVVANSYGLTGIPMISIVLPFGAANFVHYMIGFLIAAVSAFIATL FLGFKEETE*" /label="sacX CDS" gene 3322600..3323979 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /label="sacX gene" S_feature complement(3323688..3324891) /Source="Nicolas_S_feature" /locus_tag="new_3943322_3944525_c" /HighExp="Etha, B36, B60, M9-stat, Salt, Sw, LoTm, C30, Gly, Heat" /AntisenseName="sacY" /AntisenseCor="-0.177403958488455" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1477" CDS 3324033..3324875 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9305644, 9457872, 11580842, 12079345, 15528654, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9305644, 9457872, 11580842, 12079345, 15528654, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391721.1" /db_xref="EnsemblGenomes-Gn:BSU38420" /db_xref="EnsemblGenomes-Tr:CAB15868" /db_xref="GOA:P15401" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1AUU" /db_xref="SubtiList:BG10559" /db_xref="UniProtKB/Swiss-Prot:P15401" /translation="MKIKRILNHNAIVVKDQNEEKILLGAGIAFNKKKNDIVDPSKIE KTFIRKDTPDYKQFEEILETLPEDHIQISEQIISHAEKELNIKINERIHVAFSDHLSF AIERLSNGMVIKNPLLNEIKVLYPKEFQIGLWARALIKDKLGIHIPDDEIGNIAMHIH TARNNAGDMTQTLDITTMIRDIIEIIEIQLSINIVEDTISYERLVTHLRFAIQHIKAG ESIYELDAEMIDIIKEKFKDAFLCALSIGTFVKKEYGFEFPEKELCYIAMHIQRFYQR SVAR*" /label="sacY CDS" gene 3324033..3324875 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /label="sacY gene" CDS complement(3324926..3325786) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11377871, 19659723; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase (general stress protein)" /protein_id="NP_391722.1" /db_xref="EnsemblGenomes-Gn:BSU38430" /db_xref="EnsemblGenomes-Tr:CAB15869" /db_xref="GOA:P25148" /db_xref="InterPro:IPR002495" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10558" /db_xref="UniProtKB/Swiss-Prot:P25148" /translation="MRKDEIMHIVSCADDNYARHLGGMFVSLLTNMDQEREVKLYVID GGIKPDNKKRLEETTLKFGVPIEFLEVDTNMYEHAVESSHITKAAYYRISIPDLIKDE SIKRMIYIDCDALVLEDISKLWDLDIAPYTVAAVEDAGQHERLKEMNVTDTGKYFNSG IMIIDFESWRKQNITEKVINFINEHPDEDFLVLHDQDALNAILYDQWYELHPRWNAQT YIMLKLKTPSTLLGRKQYNETRENPAIVHFCGGEKPWNSNTKHPYRDEYFHYMSYTKW NTIGNPAINQ*" /label="gspA CDS" gene complement(3324926..3325786) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /label="gspA gene" downshifts complement(3324936) /Source="Nicolas_upshifts" /id="D1991" /incds=0 /nref=73 /ntot=227 /MaxReadThrough="5.61926" /MaxDrop="7.47527" /score="21.8603429" /energy="-10.6" /TU="U3025" /idTUdmin="U3025" /TUdmin="-1224" /isTUend="FALSE" /label="downshifts" downshifts 3325770 /Source="Nicolas_upshifts" /id="D1992" /incds=0 /nref=8 /ntot=30 /MaxReadThrough="1.49599" /MaxDrop="5.33818" /score="10.6843241" /energy="-4.5" /TU="NA" /idTUdmin="U3026" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3325808..3325826) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3325826) /Source="Nicolas_upshifts" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3325841..3325847) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3325896..3326609) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391723.1" /db_xref="EnsemblGenomes-Gn:BSU38440" /db_xref="EnsemblGenomes-Tr:CAB15870" /db_xref="GOA:P25149" /db_xref="InterPro:IPR011737" /db_xref="SubtiList:BG10557" /db_xref="UniProtKB/Swiss-Prot:P25149" /translation="MQKYVQSDYKHDPFHLFSTEHVVTLAIISLLAILLFLFQDEVKQ PRASRFLRSLFVFLLLGSQIGYQIWMVATDRWSVRTSLPLQLSDLSVYLSAIMLVTKS RKLFVFLFFVGIGSSIQALATPDLGMFSFPHIRYILFFISHGSVFLSCLLMAVIGTYR MGQRSLWVTVLLVNVYGVCIFLIDRWLGANYMYLTKKPGGSSLLDVLGPWPWYIVSAE AITIASFFILYWLYRIFKK*" /label="ywaF CDS" gene complement(3325896..3326609) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /label="ywaF gene" promotor_-35 3326011..3326012 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3326032..3326049 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3326034 /Source="Nicolas_upshifts" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3326637..3326648) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3326638) /Source="Nicolas_upshifts" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3326663..3326669) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3326684..3326690 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3326705..3326724 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3326715 /Source="Nicolas_upshifts" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 3326760..3327275 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25733610; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling expressionof tyrZ" /protein_id="NP_391724.1" /db_xref="EnsemblGenomes-Gn:BSU38450" /db_xref="EnsemblGenomes-Tr:CAB15871" /db_xref="GOA:P25150" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10556" /db_xref="UniProtKB/Swiss-Prot:P25150" /translation="MERSHQHQQLRKEEHDTLSKLKQMPVESLNLEAISIATNLYRSA QRLRVKMETEVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLE KKSFCRKSIDTRDRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDEQKILTGL LRKVADNLHTT*" /label="tyrZR CDS" gene 3326760..3327275 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /label="tyrZR gene" misc_RNA 3327276..3327482 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /product="T-box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboYB RNA" gene 3327276..3327482 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /label="tboYB gene" downshifts 3327442 /Source="Nicolas_upshifts" /id="D1993" /incds=0 /nref=15 /ntot=112 /MaxReadThrough="1.84575" /MaxDrop="4.56656" /score="23.8000948" /energy="-14.5" /TU="NA" /idTUdmin="U3028" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3327524..3328765 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /EC_number="6.1.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1735721, 1806041, 25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1735721, 1806041, 25733610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_391725.1" /db_xref="EnsemblGenomes-Gn:BSU38460" /db_xref="EnsemblGenomes-Tr:CAB15872" /db_xref="GOA:P25151" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024108" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10555" /db_xref="UniProtKB/Swiss-Prot:P25151" /translation="MMRTFEQLTASQQKEVERQLQLYMTGAHEVIPPEELKAKLVKSI STGTPLKIKLGLDPSAPDVHLGHTVVLNKLRQFQENGHIVQLLIGDFTGKIGDPTGKS AARKQLTDEEVQHNAKTYFEQFGKVLDPEKVELHYNSKWLKTLNLEDVIELAGKITVA RLMERDDFEERIAMQKPISLHEFFYPLMQGYDSVVLESDIELGGTDQHFNVLMGRHFQ ERYNKEKQVVILMPLLEGLDGVEKMSKSKHNYIGINEHPNDMYGKTMSLPDSLMKKYI HLATDLELEEKKQLVKDLETGAVHPRDAKMLLARTIVRMYHGEKAAEAAEHSFKTVFQ ENSLPEDIPAVNWKGEKTIAMIDLLVKLKLLSSKSEARRMIQNGGVRIDGEKVTDVHA KAEIRENMIIQVGKRKFLKLQ*" /label="tyrZ CDS" gene 3327524..3328765 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /label="tyrZ gene" promotor_-35 3328856..3328864 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3328875..3328893 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3328886 /Source="Nicolas_upshifts" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="upshifts" CDS 3328921..3330288 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15668014, 23426795, 26898926, 28257579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668014, 23426795, 26898926, 28257579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported double-zinc aminopeptidase" /protein_id="NP_391726.1" /db_xref="EnsemblGenomes-Gn:BSU38470" /db_xref="EnsemblGenomes-Tr:CAB15873" /db_xref="GOA:P25152" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR007484" /db_xref="SubtiList:BG10554" /db_xref="UniProtKB/Swiss-Prot:P25152" /translation="MKKLLTVMTMAVLTAGTLLLPAQSVTPAAHAVQISNSERELPFK AKHAYSTISQLSEAIGPRIAGTAAEKKSALLIASSMRKLKLDVKVQRFNIPDRLEGTL SSAGRDILLQAASGSAPTEEQGLTAPLYNAGLGYQKDFTADAKGKIALISRGDLTYYE KAKNAEAAGAKAVIIYNNKESLVPMTPNLSGNKVGIPVVGIKKEDGEALTQQKEATLK LKAFTNQTSQNIIGIKKPKNIKHPDIVYVTAHYDSVPFSPGANDNGSGTSVMLEMARV LKSVPSDKEIRFIAFGAEELGLLGSSHYVDHLSEKELKRSEVNFNLDMVGTSWEKASE LYVNTLDGQSNYVWESSRTAAEKIGFDSLSLTQGGSSDHVPFHEAGIDSANFIWGDPE TEEVEPWYHTPEDSIEHISKERLQQAGDLVTAAVYEAVKKEKKPKTIKKQMKAKASDI FEDIK*" /label="eapD CDS" gene 3328921..3330288 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /label="eapD gene" downshifts 3330265 /Source="Nicolas_upshifts" /id="D1994" /incds=0 /nref=3 /ntot=37 /MaxReadThrough="1.38814" /MaxDrop="6.05871" /score="27.7635079" /energy="-13.3" /TU="NA" /idTUdmin="U3029" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(3330318..3330950) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /EC_number="2.7.6.5" /function="16.7: Manage energy" /function="16.3: Control" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_391727.1" /db_xref="EnsemblGenomes-Gn:BSU38480" /db_xref="EnsemblGenomes-Tr:CAB15874" /db_xref="GOA:P39583" /db_xref="InterPro:IPR007685" /db_xref="SubtiList:BG10553" /db_xref="UniProtKB/Swiss-Prot:P39583" /translation="MDLSVTHMDDLKTVMEDWKNELLVYKFALDALDTKFSIISQEYN LIHGHNPIEHTKSRVKSFESIVNKLMRKGCEITTKEMKEHIHDIAGVRIICSFISDIY NVVNVLKQHEDLRIVKVKDYIQTPKPNGYRSLHLIIEMPVNLTNRVEYVKAEIQIRTI AMDFWASLEHKIYYKLNNDVPKQLTDELKEAAEIAHYLDEKMLGIKKEVD*" /label="relQ CDS" gene complement(3330318..3330950) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /label="relQ gene" downshifts complement(3330336) /Source="Nicolas_upshifts" /id="D1995" /incds=0 /nref=200 /ntot=257 /MaxReadThrough="2.49976" /MaxDrop="5.49802" /score="47.236042" /energy="-13.3" /TU="NA" /idTUdmin="U3030" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3330986..3331001) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3330994) /Source="Nicolas_upshifts" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3331014..3331022) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3331092..3332027) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /EC_number="2.5.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6780514, 9573170, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-dihydroxy-2-naphthoate octaprenyltransferase" /protein_id="NP_391728.1" /db_xref="EnsemblGenomes-Gn:BSU38490" /db_xref="EnsemblGenomes-Tr:CAB15875" /db_xref="GOA:P39582" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR004657" /db_xref="InterPro:IPR026046" /db_xref="SubtiList:BG10552" /db_xref="UniProtKB/Swiss-Prot:P39582" /translation="MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVL AMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFKRGLDTAESVGIGGAIVRHGMKP KTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGEL FSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRK TLAILMGHKGAVTLLAASFAVAYIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQ NEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR*" /label="menA CDS" gene complement(3331092..3332027) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /label="menA gene" downshifts complement(3331104) /Source="Nicolas_upshifts" /id="D1996" /incds=0 /nref=10 /ntot=113 /MaxReadThrough="3.08081" /MaxDrop="4.6874" /score="16.8971767" /energy="-8.5" /TU="NA" /idTUdmin="U3032" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3331771..3331780 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3331794..3331813 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3331798 /Source="Nicolas_upshifts" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3332028..3332115) /Source="Nicolas_S_feature" /locus_tag="new_3951662_3951749_c" /HighExp="LBGstat, Paraq, G180, LBGexp, G135, Oxctl, C30, Cold, Diami, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.81271400000000005" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.498" /TUlongSig="NA" /TUlongPSig="NA" /label="S1478" promotor_-10 complement(3332098..3332117) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3332115) /Source="Nicolas_upshifts" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3332133..3332137) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3332160..3332172) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3332160) /Source="Nicolas_upshifts" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3332187..3332193) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3332190..3332324) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514012.1" /translation="MECFELIHNKGKDTWSQKIFLTFKKCNVLKKIFLYLFVQVKAET *" /label="hypothetical protein CDS" gene complement(3332190..3332324) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /label="gene" promotor_-35 3332271..3332278 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-35" promotor_-10 3332292..3332311 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-10" upshifts 3332301 /Source="Nicolas_upshifts" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="upshifts" S_feature 3332304..3332408 /Source="Nicolas_S_feature" /locus_tag="new_3951938_3952042" /HighExp="H2O2, Paraq, Oxctl, G180, G150, C30, G135, LBGstat, dia15, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1479" promotor_-35 3332403..3332412 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3332410 /Source="Nicolas_upshifts" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3332424..3332439 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3332446) /Source="Nicolas_upshifts" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3332448..3332462) /Source="Nicolas_upshift_promotors" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3332474..3332623 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical membrane protein" /protein_id="YP_003097795.1" /db_xref="EnsemblGenomes-Gn:BSU38499" /db_xref="EnsemblGenomes-Tr:CAX52708" /db_xref="GOA:C0H3T3" /db_xref="InterPro:IPR021008" /db_xref="UniProtKB/Swiss-Prot:C0H3T3" /translation="MLQLMKQLYEKPAVKWTCHTGFYLMILLVLFFMYGFHTANTGSY IYNDF*" /label="ywzH CDS" gene 3332474..3332623 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /label="ywzH gene" CDS 3332641..3334152 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /EC_number="6.1.1.13" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine:D-alanyl-carrier protein ligase subunit" /protein_id="NP_391729.1" /db_xref="EnsemblGenomes-Gn:BSU38500" /db_xref="EnsemblGenomes-Tr:CAB15876" /db_xref="GOA:P39581" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR010072" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:3E7W" /db_xref="PDB:3E7X" /db_xref="SubtiList:BG10551" /db_xref="UniProtKB/Swiss-Prot:P39581" /translation="MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQ KRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAEL LIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKG VQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKD AVNKPKVLFEELKKSGLNVWTSTPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSV AKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKPDMNIFIMDE EGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIF CQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHE FEKEFQLTSAIKKELAASLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLV*" /label="dltA CDS" gene 3332641..3334152 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /label="dltA gene" CDS 3334149..3335336 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 15849754, 16850406, 17263852; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine transferase from DCP to undecaprenylphosphate for lipoteichoic acid and wall teichoic acid" /protein_id="NP_391730.1" /db_xref="EnsemblGenomes-Gn:BSU38510" /db_xref="EnsemblGenomes-Tr:CAB15877" /db_xref="GOA:P39580" /db_xref="InterPro:IPR004299" /db_xref="InterPro:IPR024024" /db_xref="InterPro:IPR024194" /db_xref="SubtiList:BG10550" /db_xref="UniProtKB/Swiss-Prot:P39580" /translation="MTPYSSFLFFILLGILLLPTIILGLNGKRFQAYNMFISIIILAL IFSHDLHGVIALCLFTIWQVLLISGYLAYRQKANSGFVFCGAVIASILPLFLSKIWPF LSHPQPHHPPHNLISFLGISYLTFKGVQLIMEARDGLLKEQLPLHRLLYFILFFPTIS SGPIDRYRRFVKDEQKAWTKEEYADLLYTGIHKIFIGFLYKFIIGYAINTYFIMNLPA ITHNKILGNLLYMYGYSMYLFFDFAGYTMFAVGVSYIMGIKSPENFNKPFISKNIKDF WNRWHMSLSFWFRDYVFMRFVFWMTKKKWIKNRMAVSNIGYFLLFMLMGVWHGLAPQY IIYGLYHAVLMTCYNFFEKWNKKYKWLPSNRWTTILAIVITFHFVCFGFYIFSGKPFH HHH*" /label="dltB CDS" gene 3334149..3335336 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /label="dltB gene" CDS 3335353..3335589 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 26193422" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 26193422; Product type c: carrier" /codon_start=1 /transl_table=11 /product="D-alanyl carrier protein" /protein_id="NP_391731.1" /db_xref="EnsemblGenomes-Gn:BSU38520" /db_xref="EnsemblGenomes-Tr:CAB15878" /db_xref="GOA:P39579" /db_xref="InterPro:IPR003230" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:4BPF" /db_xref="PDB:4BPG" /db_xref="PDB:4BPH" /db_xref="SubtiList:BG10549" /db_xref="UniProtKB/Swiss-Prot:P39579" /translation="MDFKQEVLDVLAEVCQDDIVKENPDIEIFEEGLLDSFGTVELLL AIENRFDILVPITEFDRDVWNTPNNIVNQLSELK*" /label="dltC CDS" gene 3335353..3335589 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /label="dltC gene" CDS 3335589..3336767 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 17263852, 17600057, 23858088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine from undecaprenylphosphate tothe polyglycerolphosphate chain for lipoteichoic acid andwall teichoic acid synthesis" /protein_id="NP_391732.1" /db_xref="EnsemblGenomes-Gn:BSU38530" /db_xref="EnsemblGenomes-Tr:CAB15879" /db_xref="GOA:P39578" /db_xref="InterPro:IPR006998" /db_xref="InterPro:IPR023896" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG10548" /db_xref="UniProtKB/Swiss-Prot:P39578" /translation="MKKRFFGPIILAFILFAGAIAIPSSWLTGFITDKRVKESATALN PSMFQGLYLQDQMLKDPTYLPIYGSSELSRLDEFHPSNYFQVNNEGFTPYLVGKGGSQ SLIHSLNFAAHMDQLKGKKIVFIVSPQWFIKRGSDEQHFAPNYSALQGLDLAFNDQID PEIKKKMMKRMLRFKAVQNDAILSELYKAMVNGQTWKVNALKPAAKVYYSMLEKKDLY YSTTESSGPKRYISQSVKDKSWSELNKLADQSGKRHSGSNDFHIDNPVYKKLKPKVPK LKGKNKGRSYAVSPEYGDFEMMLDILKDAGAEPMFVTIPVNGKWYDYTGFPKKGRTDY YKKVNKQIRAKGFQVADFSGHEYDPYFMKDTIHIGWKGWVYVDKAIDEFYKTGKVTSS *" /label="dltD CDS" gene 3335589..3336767 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /label="dltD gene" S_feature 3336768..3336857 /Source="Nicolas_S_feature" /locus_tag="new_3956402_3956491" /HighExp="Paraq, H2O2, Oxctl, LBGexp, Lbexp, dia0, C30, Cold, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1480" CDS 3336858..3337616 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7797557, 14665680; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391733.2" /db_xref="EnsemblGenomes-Gn:BSU38540" /db_xref="EnsemblGenomes-Tr:CAB15880" /db_xref="GOA:P39577" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10547" /db_xref="UniProtKB/Swiss-Prot:P39577" /translation="MKMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAE AKQQLPNIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELF VDGDEIELNFQAPVHLSALFTPHLMKQPEAAIVQVTSGLAFNPLAVYPVYCATKAALH SFSLTLRHQLRDTSVEVIEMAPPMVDTGLNQKSRDKQGLTYRGISSEEYVQYFLDGLK EGKQEITNERVEGLRDATRADYDRLFEQMNTQEN*" /label="dltE CDS" gene 3336858..3337616 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /label="dltE gene" downshifts 3337584 /Source="Nicolas_upshifts" /id="D1997" /incds=0 /nref=48 /ntot=172 /MaxReadThrough="5.94016" /MaxDrop="4.72547" /score="22.6844301" /energy="-13.7" /TU="U3035" /idTUdmin="U3035" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature complement(3337618..3338845) /Source="Nicolas_S_feature" /locus_tag="new_3957252_3958479_c" /HighExp="T0.30H, T1.0H, T1.30H, C30, B60, T2.0H, C90, Gly, T2.30H, S8" /AntisenseName="ilvK" /AntisenseCor="-0.12928749136401099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1481" promotor_-35 3337664..3337671 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3337685..3337704 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3337698 /Source="Nicolas_upshifts" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="upshifts" CDS 3337757..3338848 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 17611193, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 17611193, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid aminotransferase" /protein_id="NP_391734.2" /db_xref="EnsemblGenomes-Gn:BSU38550" /db_xref="EnsemblGenomes-Tr:CAB15881" /db_xref="GOA:P39576" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10546" /db_xref="UniProtKB/Swiss-Prot:P39576" /translation="MTKQTIRVELTSTKKPKPDPNQLSFGRVFTDHMFVMDYAADKGW YDPRIIPYQPLSMDPAAMVYHYGQTVFEGLKAYVSEDDHVLLFRPEKNMERLNQSNDR LCIPQIDEEQVLEGLKQLVAIDKDWIPNAEGTSLYIRPFIIATEPFLGVAASHTYKLL IILSPVGSYYKEGIKPVKIAVESEFVRAVKGGTGNAKTAGNYASSLKAQQVAEEKGFS QVLWLDGIEKKYIEEVGSMNIFFKINGEIVTPMLNGSILEGITRNSVIALLKHWGLQV SERKIAIDEVIQAHKDGILEEAFGTGTAAVISPVGELIWQDETLSINNGETGEIAKKL YDTITGIQKGAVADEFGWTTEVAALTESK*" /label="ilvK CDS" gene 3337757..3338848 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /label="ilvK gene" downshifts 3338750 /Source="Nicolas_upshifts" /id="D1998" /incds=1 /nref=10 /ntot=90 /MaxReadThrough="6.0829" /MaxDrop="3.1965" /score="32.8755878" /energy="-13.6" /TU="U3035,U3037" /idTUdmin="U3035" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 3338838 /Source="Nicolas_upshifts" /id="D1999" /incds=0 /nref=157 /ntot=264 /MaxReadThrough="2.21106" /MaxDrop="6.83094" /score="32.8755878" /energy="-13.6" /TU="NA" /idTUdmin="U3035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3338882..3340210) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8990303, 10438772, 22720735, 23874669, 24673833; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-beta-glucosidase" /protein_id="NP_391735.1" /db_xref="EnsemblGenomes-Gn:BSU38560" /db_xref="EnsemblGenomes-Tr:CAB15882" /db_xref="GOA:P46320" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11350" /db_xref="UniProtKB/Swiss-Prot:P46320" /translation="MTKGLKIVTIGGGSSYTPELVEGFIKRYDELPVRELWLVDIPEG EEKLNIVGTLAKRMVEKAGVPIDIHLTLDRRKALKDADFVTTQFRVGLLQARAKDERI PLKYGVIGQETNGPGGLFKGLRTIPVILEIAKDIEELCPNAWLVNFTNPAGMVTEALL RYSNLKKVVGLCNVPIGIKMGVAKALDVDVDRVEVQFAGLNHMVFGLDVFLDGVSVKE QVIEAMGDPKNAMTMKNISGAEWEPDFLKALNVIPCGYHRYYFKTKEMLEHELEASQT EGTRAEVVQKVEKELFELYKDPNLAIKPPQLEKRGGAYYSDAACNLISSIYNDKHDIQ PVNTINNGAIASIPDDSAVEVNCVMTKTGPKPIAVGDLPVSVRGLVQQIKSFERVAAE AAVTGDYQTALLAMTINPLVPSDTVAKQILDEMLEAHKAYLPQFFNKIEA*" /label="licH CDS" gene complement(3338882..3340210) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /label="licH gene" downshifts complement(3338890) /Source="Nicolas_upshifts" /id="D2000" /incds=0 /nref=12 /ntot=98 /MaxReadThrough="4.92442" /MaxDrop="6.75565" /score="45.1562234" /energy="-15.7" /TU="U3038" /idTUdmin="U3038" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" CDS complement(3340207..3340539) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIA component" /protein_id="NP_391736.1" /db_xref="EnsemblGenomes-Gn:BSU38570" /db_xref="EnsemblGenomes-Tr:CAB15883" /db_xref="GOA:P46319" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG11349" /db_xref="UniProtKB/Swiss-Prot:P46319" /translation="MNEEMEQIIFQIILHGGNGRSSAMEAIAAAKSGDAEEARKKLQD AAEELSKAHHYQTELIQNEAGGEKTEMTLLMVHAQDHLMNAMTVKDMAAEIIELYEKI TEQRGASI*" /label="licA CDS" gene complement(3340207..3340539) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /label="licA gene" CDS complement(3340558..3341916) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIC component" /protein_id="NP_391737.1" /db_xref="EnsemblGenomes-Gn:BSU38580" /db_xref="EnsemblGenomes-Tr:CAB15884" /db_xref="GOA:P46317" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG11348" /db_xref="UniProtKB/Swiss-Prot:P46317" /translation="MNKVNQILEEKVMPIAGRIAGQRHLQALRDGIILTMPLIIIGSF FLIIGNLPIPGYAEFMAKTFGSSWSEKLAYPVDATFEIMGLVAAFGIAYRLAEKYGVD ALSAGAISLAAFLLATPYQVPFMPDGATKEIMVGGGIPLSLMGSKGLFVAMIIAMVST EIYRLIIQRNLVFKMPDGVPPAVSKSFVALIPGFAVIFLIWAARLIVEATPFESLHNI VSVLLGTPLSILGGSLGGSLVAEAVKMLLWACGLHGANIVGGVMAPIWYGAMDANRIA FQAGEELPKIFTQQFFDIWVNIGGSGATLALVVTMFLRARSKQMKQLGKLAVGPAIFN INEPIIFGMPIVMNPMLLLPFIITPLVTVTLTYIGMSTGLVAKPAGIAVPWTMPPIFS GYLATGGKVSGAVMQAINIAVSFVVYYPFFRMWDKQKLKEENDLELVQTPAATDDKEA AL*" /label="licC CDS" gene complement(3340558..3341916) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /label="licC gene" CDS complement(3341932..3342240) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 23874669; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIB component" /protein_id="NP_391738.1" /db_xref="EnsemblGenomes-Gn:BSU38590" /db_xref="EnsemblGenomes-Tr:CAB15885" /db_xref="GOA:P46318" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11347" /db_xref="UniProtKB/Swiss-Prot:P46318" /translation="MNILLVCAAGMSTSLLVSKMEKSAQEQGKDYTIWAVSGDSVQNH IDKADVLLLGPQVRYMLPQLKKLGESKGVPVDVINTVHYGTCNGAEVLKSAEQLGHVS *" /label="licB CDS" gene complement(3341932..3342240) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /label="licB gene" promotor_-10 complement(3342285..3342304) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3342301) /Source="Nicolas_upshifts" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3342318..3342324) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3342369) /Source="Nicolas_upshifts" /id="D2001" /incds=0 /nref=3 /ntot=74 /MaxReadThrough="3.19679" /MaxDrop="2.70222" /score="27.6067633" /energy="-11.1" /TU="U3040" /idTUdmin="U3040" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3342369..3344294) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 9353933, 10438772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 9353933, 10438772; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the lichenan operon" /protein_id="NP_391739.1" /db_xref="EnsemblGenomes-Gn:BSU38600" /db_xref="EnsemblGenomes-Tr:CAB15886" /db_xref="GOA:P46321" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG11346" /db_xref="UniProtKB/Swiss-Prot:P46321" /translation="MLHGRLRDILRLLMAAEAPVTSSFFAAQLNVTTRTVRNDIKELQ GVLSGHGAFVQSVRGSGYKLRIDDEQVFRTLLQDEFQQKKGLPVLPEERMAYLMKRLL LADHYLKLDELAEELFISKSTLQTDLKEVKKRLLPYRIVMETRPNYGFKLRGDEVQMR YCMAEYIVDERETEIDVLNEKADILPKEEIEIIRSAILKKMKNDRIPLSNMGLNNLII HIAIACKRIRTENYVSLFPKDMDHILHQKEYQAAEAIVKELESKLSVTFPKDETAYIT MHLLGTKRMTQSQCGEDTFSIEEETDQLTLAMIKAVDRELKLGILHDKELKIGLALHM KPAISRNRYGMNLRNPMLAAIKEHYPLAFEAGIIAGIVIKEQTGIEIHENEIGYLALH FGAAIERKKTESPPKRCIIVCASGAGSAQLLREKLRSHFGKRLDILGTAEYYSLDQMS YESIDFVISTIPIKKELPVPVLKVNTILGGTDFTKIESILSDEKEKANRYLKKELVFF QEDLRSKEEVIQFLGQKVVECGFADEEIIDSIFEREDMSPTCFGNLVAIPHPLVPQTK TTFWAVCTLKKPIDWESQRVQFVCLLCVEKENKADLQSMYKLLGSILDDPAAMNQLIK CRSYQELSDVFDQKMLS*" /label="licR CDS" gene complement(3342369..3344294) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /label="licR gene" promotor_-35 3343032..3343041 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3343055..3343074 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3343063 /Source="Nicolas_upshifts" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3344367..3344384) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-10" upshifts complement(3344391) /Source="Nicolas_upshifts" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="upshifts" promotor_-35 complement(3344399..3344406) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-35" CDS complement(3344457..3344615) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391740.1" /db_xref="EnsemblGenomes-Gn:BSU38610" /db_xref="EnsemblGenomes-Tr:CAB15887" /db_xref="SubtiList:BG14169" /db_xref="UniProtKB/Swiss-Prot:O32283" /translation="MVEKKEGRIGALKKMIKTVIKWAPVIYPIVRKIMKDRKASKQKN MSASRTAG*" /label="yxzF CDS" gene complement(3344457..3344615) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /label="yxzF gene" downshifts complement(3344484) /Source="Nicolas_upshifts" /id="D2002" /incds=0 /nref=75 /ntot=208 /MaxReadThrough="0.739420000000001" /MaxDrop="6.4099" /score="27.6067633" /energy="-11.1" /TU="NA" /idTUdmin="U3041" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3344644..3345234) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /EC_number="3.2.2.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14729667, 27698084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14729667, 27698084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-alkylated purines and hypoxanthine DNA glycosidase" /protein_id="NP_391741.1" /db_xref="EnsemblGenomes-Gn:BSU38620" /db_xref="EnsemblGenomes-Tr:CAB15888" /db_xref="GOA:P94378" /db_xref="InterPro:IPR003180" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036995" /db_xref="SubtiList:BG12555" /db_xref="UniProtKB/Swiss-Prot:P94378" /translation="MTREKNPLPITFYQKTALELAPSLLGCLLVKETDEGTASGYIVE TEAYMGAGDRAAHSFNNRRTKRTEIMFAEAGRVYTYVMHTHTLLNVVAAEEDVPQAVL IRAIEPHEGQLLMEERRPGRSPREWTNGPGKLTKALGVTMNDYGRWITEQPLYIESGY TPEAISTGPRIGIDNSGEARDYPWRFWVTGNRYVSR*" /label="aag CDS" gene complement(3344644..3345234) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /label="aag gene" promotor_-10 complement(3345262..3345280) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3345273) /Source="Nicolas_upshifts" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3345294..3345300) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3345303..3345309 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3345325..3345343 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3345328 /Source="Nicolas_upshifts" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="upshifts" CDS 3345363..3347006 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9393707, 9555886, 10503549, 24123749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9555886, 10503549, 24123749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="major catalase in spores" /protein_id="NP_391742.1" /db_xref="EnsemblGenomes-Gn:BSU38630" /db_xref="EnsemblGenomes-Tr:CAB15889" /db_xref="GOA:P94377" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11945" /db_xref="UniProtKB/Swiss-Prot:P94377" /translation="MKDDHQNKQHQSNAQGSEEAFSHKTSGKNESEDTLTNRQGHPVT DNQNVRTVGNRGPTTLENYDFLEKISHFDRERIPERVVHARGAGAHGYFEAYGSFGDE PISTYTRAKLFQEKGKKTPAFVRFSTVNHGKHSPETLRDPRGFAVKLYTEDGNWDLVG NNLKIFFIRDPLKFPDLVHAFQPDPVTNIQDGERIFDFISQSPEATHMITFLFSPWGI PANYRQMQGSGVHAYKWVNEEGKAVLVKYHFEPKQGIRNLTQKEAEEIQGKNFNHATQ DLYDAIENGDYPEWEVYAQIMSDDEHPELDFDPLDPTKLWYKDDFPWKPIGKLVLNKN PENYHAEVEQASFGTGVLVDGLDFSDDKLLQGRTFAYSDTQRYRVGANYLQLPINSPK KHVATNQEGGQMQYRVDRAEGQNPHVNYEPSIMGGLKEAKQDGKDHTPHVEGDVKREA IDRTNNFGQAGETYRRFTEFERNELITNLVNTLSTCRKEIQDQMIENFTKADPDYGKR VAEGLKKVSENNSNGPIGTTETEQAAKQAEQESHPSDPY*" /label="katX CDS" gene 3345363..3347006 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /label="katX gene" S_feature complement(3345500..3347049) /Source="Nicolas_S_feature" /locus_tag="new_3965134_3966683_c" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T3.0H, S8, T3.30H, S6, T0.0H" /AntisenseName="katX" /AntisenseCor="0.28909015498211399" /AntisenseRegPval="-5.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1482" downshifts 3347001 /Source="Nicolas_upshifts" /id="D2003" /incds=0 /nref=28 /ntot=49 /MaxReadThrough="0.942820000000001" /MaxDrop="5.69337" /score="45.0252072" /energy="-12.7" /TU="NA" /idTUdmin="U3042" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3347051..3347142) /Source="Nicolas_S_feature" /locus_tag="new_3966685_3966776_c" /HighExp="T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, T3.30H, T4.0H, T3.0H, T0.0H, T5.0H" /AntisenseName="yxlH" /AntisenseCor="-4.8005444617814199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1483" promotor_-35 3347053..3347059 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3347067 /Source="Nicolas_upshifts" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3347074..3347093 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3347094) /Source="Nicolas_upshifts" /id="D2004" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="3.81662" /MaxDrop="3.1285" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1557" /isTUend="FALSE" /label="downshifts" CDS 3347111..3348313 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391743.1" /db_xref="EnsemblGenomes-Gn:BSU38640" /db_xref="EnsemblGenomes-Tr:CAB15890" /db_xref="GOA:P94376" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12554" /db_xref="UniProtKB/Swiss-Prot:P94376" /translation="MELQQDLIPQKKTIGALDHAVFLCMVFCFWFSGYIYVPVFSLYL EDLHFSYGAIGIILGSYGVTQILLRFPLGLLSDILFSLRKQLLIAGFGFSVLSSLLFL MFDSFFFVLAARLFAGITASTWVMATILYAHYFNNGNASKAMGIMQFFTVMPQFASIV FCGLAAAHLGRQVPFWMALAASAAGLVICCFIQDPSAPPANRGTIRVNQYIKDTLRLP KLKLFTILSMTAHAVLFITVFGFTPLYMNQLGMGDAELLWVMSAFFLPHAAATLSFVF LRFTSRIAYSVMLISFAVTGVCLLYVPFLAALFTVCITHACIGLALGFVFPLLLSHVV EISSARLKMSVMGFYQSFYALGIFLGPLLAGKIAQLIGLAGVFYGAGSLAFAAFFVML AQKRNMIN*" /label="yxlH CDS" gene 3347111..3348313 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /label="yxlH gene" S_feature complement(3347144..3348309) /Source="Nicolas_S_feature" /locus_tag="new_3966778_3967943_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T0.0H, T3.0H, T3.30H, T-0.40H, T4.0H" /AntisenseName="yxlH" /AntisenseCor="-4.5703316381945601E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1484" downshifts complement(3347187) /Source="Nicolas_upshifts" /id="D2005" /incds=1 /nref=3 /ntot=61 /MaxReadThrough="6.44992" /MaxDrop="2.92619" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS complement(3348310..3349086) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC-transporter (permease)" /protein_id="NP_391744.2" /db_xref="EnsemblGenomes-Gn:BSU38650" /db_xref="EnsemblGenomes-Tr:CAB15891" /db_xref="GOA:P94375" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12553" /db_xref="UniProtKB/Swiss-Prot:P94375" /translation="MKVMMALLQKEWLEGWKSGKLIWLPIAMMIVGLTQPLTIYYMPE IIAHGGNLPDGMKISFTMPSGSEVMVSTLSQFNTLGMALVIFSVMGSVANERNQGVTA LIMSRPVTAAHYIVSKWLIQSVIGIMSFAAGYGLAYYYVRLLFEDASFSRFAASLGLY ALWVIFIVTAGLAGSTIFRSVGAAAACGIGLTAAVSFAVSLFPDGAKWLPAEICKQAE HILLHGERADFFGWSLTFSILCIMLLAVFSVWRFRRYESY*" /label="yxlG CDS" gene complement(3348310..3349086) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /label="yxlG gene" CDS complement(3349083..3349970) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter component (ATP-binding protein)" /protein_id="NP_391745.1" /db_xref="EnsemblGenomes-Gn:BSU38660" /db_xref="EnsemblGenomes-Tr:CAB15892" /db_xref="GOA:P94374" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12552" /db_xref="UniProtKB/Swiss-Prot:P94374" /translation="MLSIESLCKSYRHHEAVKNVSFHVNENECVALLGPNGAGKTTTL QMLAGLLSPTSGTIKLLGEKKLDRRLIGYLPQYPAFYSWMTANEFLTFAGRLSGLSKR KCQEKIGEMLEFVGLHEAAHKRIGGYSGGMKQRLGLAQALLHKPKFLILDEPVSALDP TGRFEVLDMMRELKKHMAVLFSTHVLHDAEQVCDQVVIMKNGEISWKGELQELKQQQQ TNVFTLSVKEKLEGWLEEKPYVSAIVYKNPSQAVFELPDIHAGRSLLSDCIRKGLTVT RFEQKTESLEDVYLKVVHA*" /label="yxlF CDS" gene complement(3349083..3349970) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /label="yxlF gene" CDS complement(3349977..3350165) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma-Y activity" /protein_id="NP_391746.1" /db_xref="EnsemblGenomes-Gn:BSU38670" /db_xref="EnsemblGenomes-Tr:CAB15893" /db_xref="GOA:P94373" /db_xref="InterPro:IPR027379" /db_xref="SubtiList:BG12551" /db_xref="UniProtKB/Swiss-Prot:P94373" /translation="MNISWEMILPLIVLQLALAVFALISCIKEERTNGPKWMWAAIIV CINIIGPILFFTVGRKQR*" /label="yxlE CDS" gene complement(3349977..3350165) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /label="yxlE gene" CDS complement(3350162..3350368) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative sigma-Y antisigma factor component" /protein_id="NP_391747.1" /db_xref="EnsemblGenomes-Gn:BSU38680" /db_xref="EnsemblGenomes-Tr:CAB15894" /db_xref="GOA:P94372" /db_xref="SubtiList:BG12550" /db_xref="UniProtKB/Swiss-Prot:P94372" /translation="MTQTEIIITVAACLIVLAQGIFLFIDAKKRNHMAWVWGIVGLIQ APMPLICYYFFVIRPDRKKRGIKQ*" /label="yxlD CDS" gene complement(3350162..3350368) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /label="yxlD gene" CDS complement(3350365..3350685) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sigma-Y antisigma factor" /protein_id="NP_391748.1" /db_xref="EnsemblGenomes-Gn:BSU38690" /db_xref="EnsemblGenomes-Tr:CAB15895" /db_xref="GOA:P94371" /db_xref="InterPro:IPR035238" /db_xref="SubtiList:BG12549" /db_xref="UniProtKB/Swiss-Prot:P94371" /translation="MNKEKLSDHLKSEWKKIDQTANPSIPNQKELLHQLSQMKAEYRK KLLQEIILFVFCALMVVSAAILAFTQAPAVFIVLQVCVLAVLPILIAAEKKRHLGECE VKRG*" /label="yxlC CDS" gene complement(3350365..3350685) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /label="yxlC gene" promotor_-35 3350498..3350507 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3350520..3350539 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3350522 /Source="Nicolas_upshifts" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3350678..3351214) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y)" /protein_id="NP_391749.1" /db_xref="EnsemblGenomes-Gn:BSU38700" /db_xref="EnsemblGenomes-Tr:CAB15896" /db_xref="GOA:P94370" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11975" /db_xref="UniProtKB/Swiss-Prot:P94370" /translation="MDTQEEQRLIQQAKEGNDEAFTALFHYHYSFLYKYLLKLSLHPD LSEELVQETFLKGYIHLRSFQGRSKFSTWLISIASRLYLDHQKKRKREWKRNQTVTEE TIRKIKWDVSAKGAEWSETLDLFSKLDPKLRTPVLLRHYYGYTYAEIGVMLQIKEGTV KSRVHKGLQQIRKEWDDE*" /label="sigY CDS" gene complement(3350678..3351214) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /label="sigY gene" upshifts complement(3351242) /Source="Nicolas_upshifts" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3351243..3351258) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3351270..3351279) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3351345..3351352 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3351366..3351385 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3351375 /Source="Nicolas_upshifts" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="upshifts" CDS 3351426..3352799 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2191181, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine-cytosine (pyridoxine) permease" /protein_id="NP_391750.1" /db_xref="EnsemblGenomes-Gn:BSU38710" /db_xref="EnsemblGenomes-Tr:CAB15897" /db_xref="GOA:P94369" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR026030" /db_xref="SubtiList:BG12548" /db_xref="UniProtKB/Swiss-Prot:P94369" /translation="MKVERRTIEYIPNEERHGKAKDLFPVWFGANMHITTLVTGTIPV AMGLNLFWSVAAIICGTLIGAIFMASHSAQGPQLGIPQMIQSRAQFGVIGAILPLFLV MFIYLGFFASSTILAAGTLSSFVPIPGSWSIIGLSAVCFLLTIFGHDLIHKMQKILSW TSFAVFFAATILIFQLPIPAGSWIPGAIDLPIFLVAVSAVATWQLAYAPYVADYSRYL PVKTPASKTFWYSYAGTSVSSIWMMLLGALLTTSLPDFTANSGSQIVQLFGPFSFIML IIVLFGQMAINVFNLYGAFMSTTTTLEPFLKLKVTPKVRIIMILGVTLVGTVLSLLGQ SNFMELFLNFIFFISYFLIPWTAINLVDYYFVRHGKYQVKAMFDVNGPYGKVNWITTI AFVLSILLEIPFINTSFYIGPLAKMFGGGDIAWIIGLAVPSVLYYVLMKPRLKKRAGY QEKLSSL*" /label="yxlA CDS" gene 3351426..3352799 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /label="yxlA gene" S_feature complement(3351706..3352248) /Source="Nicolas_S_feature" /locus_tag="new_3971340_3971882_c" /HighExp="Etha, LBGstat, T1.0H, T0.30H, Diami, T1.30H, dia15, G150, G135, G180" /AntisenseName="yxlA" /AntisenseCor="-8.6586358833710395E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1485" promotor_-10 complement(3352236..3352255) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3352248) /Source="Nicolas_upshifts" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3352270..3352277) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3352634 /Source="Nicolas_upshifts" /id="D2006" /incds=1 /nref=30 /ntot=136 /MaxReadThrough="1.87017" /MaxDrop="3.59478" /score="22.3054019" /energy="-12.9" /TU="NA" /idTUdmin="U3046" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3352814..3353644) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12457846, 21994945, 22940582, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12457846, 21994945, 22940582, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H dehydratase" /protein_id="NP_391751.1" /db_xref="EnsemblGenomes-Gn:BSU38720" /db_xref="EnsemblGenomes-Tr:CAB15898" /db_xref="GOA:P94368" /db_xref="InterPro:IPR000631" /db_xref="InterPro:IPR017953" /db_xref="InterPro:IPR029056" /db_xref="PDB:1KYH" /db_xref="PDB:3RPH" /db_xref="PDB:3RPZ" /db_xref="PDB:3RQ2" /db_xref="PDB:3RQ5" /db_xref="PDB:3RQ6" /db_xref="PDB:3RQ8" /db_xref="PDB:3RQH" /db_xref="PDB:3RQQ" /db_xref="PDB:3RQX" /db_xref="SubtiList:BG12547" /db_xref="UniProtKB/Swiss-Prot:P94368" /translation="MNVPFWTEEHVRATLPERDAESHKGTYGTALLLAGSDDMPGAAL LAGLGAMRSGLGKLVIGTSENVIPLIVPVLPEATYWRDGWKKAADAQLEETYRAIAIG PGLPQTESVQQAVDHVLTADCPVILDAGALAKRTYPKREGPVILTPHPGEFFRMTGVP VNELQKKRAEYAKEWAAQLQTVIVLKGNQTVIAFPDGDCWLNPTGNGALAKGGTGDTL TGMILGMLCCHEDPKHAVLNAVYLHGACAELWTDEHSAHTLLAHELSDILPRVWKRFE *" /label="nnrA CDS" gene complement(3352814..3353644) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /label="nnrA gene" downshifts complement(3352820) /Source="Nicolas_upshifts" /id="D2007" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="3.50755" /MaxDrop="3.84264" /score="7.61210868" /energy="-12.9" /TU="U3048" /idTUdmin="U3051" /TUdmin=792 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3353663..3353681) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3353678) /Source="Nicolas_upshifts" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3353696..3353702) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3353722) /Source="Nicolas_upshifts" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3353724..3353743) /Source="Nicolas_upshift_promotors" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3353730..3355457) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391752.1" /db_xref="EnsemblGenomes-Gn:BSU38730" /db_xref="EnsemblGenomes-Tr:CAB15899" /db_xref="GOA:P94367" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014223" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11928" /db_xref="UniProtKB/Swiss-Prot:P94367" /translation="MKKEEWILPYIKQNARLFVLVIFLGAVTIFSAAFLMFTSGFLIS KAATRPENILLIYVPIVAVRTFGIARSVSRYVERLVGHHIILKIVSDMRVRLYNMLEP GALMLRSRFRTGDMLGILSEDIEHLQDAFLKTIFPAISALLLYAVSVIALGFFSWPFA ILLALYLFVLVVLFPVVSLLVTRAKNAKLKSGRNVLYSRLTDAVMGVSDWMFSGRRHA FIDAYEKEERDWFELERKKQRFTRWRDFAAQCLVAGLILLMLFWTAGQQADGELAKTM IAAFVLVVFPLTEAFLPLSDALGEVPGYQDSIRRMNNVAPQPEASQTESGDQILDLQD VTLAFRDVTFSYDNSSQVLHNFSFTLRQGEKMALLGRSGSGKSTSLALIEGALKPDSG SVTLNGVETALLKDQIADAVAVLNQKPHLFDTSILNNIRLGNGEASDEDVRRAAKQVK LHDYIESLPDGYHTSVQETGIRFSGGERQRIALARILLQDTPIIILDEPTVGLDPITE RELMETVFEVLKGKTILWITHHLAGVEAADKIVFLENGKTEMEGTHEELLAANERYRR LYHLDVPVK*" /label="cydD CDS" gene complement(3353730..3355457) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /label="cydD gene" downshifts complement(3353829) /Source="Nicolas_upshifts" /id="D2008" /incds=1 /nref=7 /ntot=46 /MaxReadThrough="5.39758" /MaxDrop="3.66431" /score="25.0271963" /energy="-10.6" /TU="U3051" /idTUdmin="U3051" /TUdmin="-217" /isTUend="FALSE" /label="downshifts" CDS complement(3355454..3357157) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391753.1" /db_xref="EnsemblGenomes-Gn:BSU38740" /db_xref="EnsemblGenomes-Tr:CAB15900" /db_xref="GOA:P94366" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014216" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11927" /db_xref="UniProtKB/Swiss-Prot:P94366" /translation="MGKDLFRYKGMKRILTLITCLTLIQTAAIIMQAEWLSEAVTGLF NGKGITSLLPVIGFFLIAFIARHGMTVARQKIVYQYAARTGADLRKSFLDQLFRLGPR FAKKEGTGQMVTLAMEGISQFRRYLELFLPKMVSMAIVPAAVVIYVFFQDRTSAIILV AAMPILIIFMILLGLVAQRKADRQWKSYQRLSNHFVDSLRGLETLRFLGLSKSHSKNI FYVSERYRKATMSTLRVAFLSSFALDFFTMLSVATVAVFLGLRLIDGDILLGPALTAL ILAPEYFLPVREVGNDYHATLNGQEAGKTIQEILSQPGFKEETPLQLEAWSDQDELKL SGVSVGRSVSDIHLSFKGKKKIGIIGASGAGKSTLIDILGGFLEPDGGMIEVNGTSRS HLQDGSWQKNLLYIPQHPYIFDDTLGNNIRFYHPSASAEDTTRAAASAGLTELVNNLP DGLEGRIGEGGRALSGGQAQRVALARAFLGNRPILLLDEPTAHLDIETEYEIKETMLD LFEDKLVFLATHRLHWMLDMDEIIVLDGGRVAEIGTHNELLEKNGVYTKLVKAQLGER A*" /label="cydC CDS" gene complement(3355454..3357157) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /label="cydC gene" CDS complement(3357157..3358173) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit II)" /protein_id="NP_391754.1" /db_xref="EnsemblGenomes-Gn:BSU38750" /db_xref="EnsemblGenomes-Tr:CAB15901" /db_xref="GOA:P94365" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG11926" /db_xref="UniProtKB/Swiss-Prot:P94365" /translation="MASLHDLWFILVAVLFVGFFFLEGFDFGVGMATRFLGHNELERR VLINTIGPFWDANEVWLLTGAGAIFAAFPNWYATMLSGYYIPFVIVLLALMGRGVAFE FRGKVDHLKWVKVWDWVVFFGSLIPPFVLGVLFTTLFRGMPIDADMNIHAHVSDYINV YSILGGVTVTLLCFQHGLMFITLRTIGDLQNRARKMAQKIMGVVFVAVLAFAALSAYQ TDMFTRRGEITIPLAVLIVICFMLAAVFIRKKKDGWTFGMTGAGLALTVGMIFISLFP RVMVSSLHSAYDLTVANASSGDYSLKVMSIAALTLLPFVIGSQIWSYYVFRKRVSHKE PMTY*" /label="cydB CDS" gene complement(3357157..3358173) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /label="cydB gene" promotor_-10 complement(3358047..3358065) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3358056) /Source="Nicolas_upshifts" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3358081..3358086) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3358157..3359563) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit I)" /protein_id="NP_391755.1" /db_xref="EnsemblGenomes-Gn:BSU38760" /db_xref="EnsemblGenomes-Tr:CAB15902" /db_xref="GOA:P94364" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG11925" /db_xref="UniProtKB/Swiss-Prot:P94364" /translation="MSELVLARIQFASTTLFHFLFVPMSIGLVFMVALMETLYLVKKN ELYLKMAKFWGHLFLINFAVGVVTGILQEFQFGLNWSDYSRFVGDVFGAPLAIEALLA FFMESIFIGLWIFGWDRLPKKIHALCIWLVSFGTIMSSFWILTANSFMQEPVGFTIKN GRAEMNDFGALITNPQLWVEFPHVIFGALATGAFFIAGVSAFKLLKKKEVPFFKQSFK LAMIVGLCAGLGVGLSGHMQAEHLMESQPMKMAASEGLWEDSGDPAAWTAFATIDTKN EKSSNEIKVPYALSYLAYQKFSGSVKGMKTLQAEYEKIYGKGDYIPPVKTTFWSFRIM VGAGVVMILAALGGLWLNRRKKLENSKWYLRIMIALISFPFLANSAGWIMTEIGRQPW TVMGLMTTAQSVSPNVTAGSLLFSIIAFGVMYMILGALLVFLFIREIKKGAEHDNHHD VPVSTDPFSQEVYHGISS*" /label="cydA CDS" gene complement(3358157..3359563) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /label="cydA gene" S_feature complement(3359564..3359772) /Source="Nicolas_S_feature" /locus_tag="new_3979198_3979406_c" /HighExp="M0t45, ferm, UNK1, Gly, Lbexp, Lbstat, dia0, nit, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1486" promotor_-10 complement(3359755..3359774) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3359772) /Source="Nicolas_upshifts" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3359774..3359882) /Source="Nicolas_S_feature" /locus_tag="new_3979408_3979516_c" /HighExp="LPhT, LBGtran, ferm, LBGstat, M0t45, dia0, Etha, dia5, Lbexp, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1487" promotor_-35 complement(3359788..3359793) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3359879..3359898) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-10" upshifts complement(3359894) /Source="Nicolas_upshifts" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="upshifts" promotor_-35 complement(3359912..3359919) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-35" promotor_-35 3360040..3360047 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3360057 /Source="Nicolas_upshifts" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3360062..3360080 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3360119..3361471 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11566984, 12525174, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11566984, 12525174, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="citrate/malate/H+ symporter" /protein_id="NP_391756.1" /db_xref="EnsemblGenomes-Gn:BSU38770" /db_xref="EnsemblGenomes-Tr:CAB15903" /db_xref="GOA:P94363" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12546" /db_xref="UniProtKB/Swiss-Prot:P94363" /translation="MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALL FILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGKSIPIVRSIGGPAILATFIPSAV VYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVG SVTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAF ALVLPSIMLGSLCAIILAGLLNRIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFN LSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFRLVPASIENGAFGVS RFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMY PIETAIINACHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY *" /label="cimH CDS" gene 3360119..3361471 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /label="cimH gene" S_feature complement(3361070..3363552) /Source="Nicolas_S_feature" /locus_tag="new_3980704_3983186_c" /HighExp="Cold, C30, LBGstat, Paraq, GM 120, GM 90, H2O2, Oxctl, GM 25, GM 45" /AntisenseName="yxkI" /AntisenseCor="0.564471040461903" /AntisenseRegPval="-23.3" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1488" downshifts 3361456 /Source="Nicolas_upshifts" /id="D2009" /incds=0 /nref=63 /ntot=147 /MaxReadThrough="2.93791" /MaxDrop="3.97692" /score="3.68725156" /energy="-12.7" /TU="U3053" /idTUdmin="U3053" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3361547..3361566 /Source="Nicolas_upshift_promotors" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3361553 /Source="Nicolas_upshifts" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="upshifts" CDS 3361593..3363281 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_391757.1" /db_xref="EnsemblGenomes-Gn:BSU38780" /db_xref="EnsemblGenomes-Tr:CAB15904" /db_xref="GOA:P94362" /db_xref="InterPro:IPR001915" /db_xref="SubtiList:BG12545" /db_xref="UniProtKB/Swiss-Prot:P94362" /translation="MPMGTHLFLFMLLGLGFYLISALAAKLIPAIDFWIDIVLWVGAA AYIFSHLSFMDGIVSLATMFYCYWTAMDLIVSERVEKPSGDWQEIELAKNKTRLLSDI TLTAIVFAGAVIFFIYGPDTSPLKYVILLGMISGGGALVKRILNVFSVKVFYSAALEK LHISSHYETRTYPLSDLKNIQLESTADLLKLHPLLTMYSSRLDLTTSFQQVIKLSLPG ETLFLTVKEPQKWKTILQEYTDAENNVDNVISVLPFYHRKNVKRLLGKLYFAASVKGV SAYALLVLALYALHASPWVMAVAVILYWVFNMYMSDRVLRAAMDAKSCHHPHVQAAAD KIFRSAGISHVRIYETESDDYNGMAVGMNVGRSMVILTSATLTLPQRVIEGILAHEAI HIKKRDVLSSQLLRFLYLGAVVGIFLLFEQHITHPEAHKIALWAFIMAIIILFQLYQS FCSQWMEVRADNLGASLLDGGYKQMAEALRILAVRQDEDIQKQSAYSSEAGEDELQID SLTRDKSWFFRLIDFQFAPHPPMYWRVGTLLSNKGHGVLKRWLRDRLKESITLK*" /label="yxkI CDS" gene 3361593..3363281 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /label="yxkI gene" promotor_-35 3363279..3363288 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3363300..3363315 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3363304 /Source="Nicolas_upshifts" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="upshifts" CDS 3363339..3363539 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391758.1" /db_xref="EnsemblGenomes-Gn:BSU38790" /db_xref="EnsemblGenomes-Tr:CAB15905" /db_xref="SubtiList:BG14168" /db_xref="UniProtKB/Swiss-Prot:O32284" /translation="MIVIILLFISIIVFLSVIQPQPSKNKSRQQADSGYFGYSDHSSH HDGCSSDGGFSDSGCGGGGGGD*" /label="yxzE CDS" gene 3363339..3363539 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /label="yxzE gene" S_feature 3363540..3364484 /Source="Nicolas_S_feature" /locus_tag="new_3983174_3984118" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T0.0H, T-0.40H, Salt, T3.30H, T3.0H" /AntisenseName="yxkH" /AntisenseCor="0.147753218660366" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1489" CDS complement(3363553..3364392) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported polysaccharide deacetylase, lipoprotein" /protein_id="NP_391759.1" /db_xref="EnsemblGenomes-Gn:BSU38800" /db_xref="EnsemblGenomes-Tr:CAB15906" /db_xref="GOA:P94361" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG12544" /db_xref="UniProtKB/Swiss-Prot:P94361" /translation="MKRLFLSIFLLGSCLALAACADQEANAEQPMPKAEQKKPEKKAV QVQKKEDDTSAWIKTEKPAKLPILMYHSISSGNSLRVPKKEFEAHMKWLHDNGYQTLT PKEASLMLTQDKKPSEKCVLITFDDGYTDNYQDAYPVLKKYGMKATIFMIGKSIGHKH HLTEEQMKEMAQHGISIESHTIDHLELNGLTPQQQQSEMADSKKLFDNMFHQQTTIIS YPVGRYNEETLKAAEKTGYQMGVTTEPGAASRDQGMYALHRVRVSPGMSGSAFGAYIE SMK*" /label="yxkH CDS" gene complement(3363553..3364392) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /label="yxkH gene" promotor_-10 complement(3364418..3364436) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3364436) /Source="Nicolas_upshifts" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3364449..3364456) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3364451 /Source="Nicolas_upshifts" /id="D2010" /incds=0 /nref=27 /ntot=142 /MaxReadThrough="0.40982" /MaxDrop="6.50242" /score="33.6694147" /energy="-13.4" /TU="NA" /idTUdmin="U3055" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(3364499..3365596) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multiple sugar (maltodextrins) transporter ATP-binding protein" /protein_id="NP_391760.1" /db_xref="EnsemblGenomes-Gn:BSU38810" /db_xref="EnsemblGenomes-Tr:CAB15907" /db_xref="GOA:P94360" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005116" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11954" /db_xref="UniProtKB/Swiss-Prot:P94360" /translation="MAELRMEHIYKFYDQKEPAVDDFNLHIADKEFIVFVGPSGCGKS TTLRMVAGLEEISKGDFYIEGKRVNDVAPKDRDIAMVFQNYALYPHMTVYDNIAFGLK LRKMPKPEIKKRVEEAAKILGLEEYLHRKPKALSGGQRQRVALGRAIVRDAKVFLMDE PLSNLDAKLRVQMRAEIIKLHQRLQTTTIYVTHDQTEALTMATRIVVMKDGKIQQIGT PKDVYEFPENVFVGGFIGSPAMNFFKGKLTDGLIKIGSAALTVPEGKMKVLREKGYIG KEVIFGIRPEDIHDELIVVESYKNSSIKAKINVAELLGSEIMIYSQIDNQDFIARIDA RLDIQSGDELTVAFDMNKGHFFDSETEVRIR*" /label="msmX CDS" gene complement(3364499..3365596) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /label="msmX gene" downshifts complement(3364500) /Source="Nicolas_upshifts" /id="D2011" /incds=0 /nref=81 /ntot=171 /MaxReadThrough="3.31232" /MaxDrop="7.04855" /score="29.2689404" /energy="-14.4" /TU="U3057" /idTUdmin="U3058" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3365629..3365648) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3365646) /Source="Nicolas_upshifts" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3365648..3365716) /Source="Nicolas_S_feature" /locus_tag="new_3985282_3985350_c" /HighExp="M0t90, M40t90, Lbstat, Lbtran, T2.0H, dia5, T2.30H, M9-stat, S2, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1490" promotor_-35 complement(3365661..3365668) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3365717..3366610) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10746760" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10746760; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates yxkF-msmX expression)" /protein_id="NP_391761.1" /db_xref="EnsemblGenomes-Gn:BSU38820" /db_xref="EnsemblGenomes-Tr:CAB15908" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12543" /db_xref="UniProtKB/Swiss-Prot:P94359" /translation="MKSLLAIYPGSIVSEELCIREGCLCFFDESNQRYISIPKTEISE KEVLVLQSFLTPADEGNQLSMKSPEENKWFSFLFSRGELPAYIKKRTRFVHFHLFGKI ERTSFTEAVRHFWPVSFVIVWIHEDRGVIVEQESEAAAEKDELESLAKVLESDFYFSV RFYAGRFYEPDECLRKHYAREQAYFLFAEKRLPQVQSVTFEMIFPFLLLETEKEKLET LLSEEAELLFGSESELRKTIKLFIENNSNVTLTAKKLHLHRNSLQYRIDKFIERSGID IKSYKGALLAYFICLQNESSE*" /label="yxkF CDS" gene complement(3365717..3366610) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /label="yxkF gene" promotor_-10 complement(3366637..3366656) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3366656) /Source="Nicolas_upshifts" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3366670..3366677) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3366684..3366689 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3366705..3366723 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3366714 /Source="Nicolas_upshifts" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3366731..3366737 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3366752..3366770 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3366758 /Source="Nicolas_upshifts" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="upshifts" CDS 3366794..3368251 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391762.1" /db_xref="EnsemblGenomes-Gn:BSU38830" /db_xref="EnsemblGenomes-Tr:CAB15909" /db_xref="GOA:P94358" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="PDB:4DNG" /db_xref="SubtiList:BG11903" /db_xref="UniProtKB/Swiss-Prot:P94358" /translation="MSFETLNKSFINGKWTGGESGRTEDILNPYDQSVITTASLATGK QLEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKST IELEQTIAILDEAMTYTGELGGVKEVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLS MRSIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGM LTNPIPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAI FGKFIHQGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQ IEKALEIIEQAKTDGIELAVEGKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKA GSDQEAIDMANDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHVNDQSVNDSPNIAFGG NKASGVGRFGNPWVVEEFTVTKWISIQKQYRKYPF*" /label="aldY CDS" gene 3366794..3368251 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /label="aldY gene" promotor_-10 complement(3367677..3367695) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3367692) /Source="Nicolas_upshifts" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3367710..3367715) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3368232 /Source="Nicolas_upshifts" /id="D2012" /incds=0 /nref=14 /ntot=39 /MaxReadThrough="1.43471" /MaxDrop="4.03346" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 3368276 /Source="Nicolas_upshifts" /id="D2013" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="1.40793" /MaxDrop="3.07407" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3368293..3369129) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10735877, 10931887, 15096624, 15849754, 16850406, 21317561; Product type t : transporter" /codon_start=1 /transl_table=11 /product="guanidinium exporter" /protein_id="NP_391763.1" /db_xref="EnsemblGenomes-Gn:BSU38840" /db_xref="EnsemblGenomes-Tr:CAB15910" /db_xref="GOA:P94357" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12542" /db_xref="UniProtKB/Swiss-Prot:P94357" /translation="MKKRMLDVLMLVIGAFFFALAVNLFAIPNDLGEGGVTGITLILY YLFQWSPGVTNFILNAFLLLIGYKFLDGKTTVYTIIAVAANSLFLHLTHGWSIPSDEL IINTIFAGVFAGVGIGMIIRVGGTTAGSAILARIANKYLDWNISYALLFFDLIVVFSS YFIIGAEKMMFTIVMLYIGTKVMDFIIEGLNTKKAITVISENKSEIAEQVNTLMDRGV TILSGKGNYTGQSKEILYIVINKQELSMLKKIIRSCDKKAFVIVHDVRDVFGEGFVDI SK*" /label="gdnE CDS" gene complement(3368293..3369129) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /label="gdnE gene" downshifts complement(3368311) /Source="Nicolas_upshifts" /id="D2014" /incds=0 /nref=19 /ntot=137 /MaxReadThrough="1.00689" /MaxDrop="4.07213" /score="21.5028874" /energy="-13.8" /TU="NA" /idTUdmin="U3062" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" misc_RNA complement(3369206..3369308) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /product="guanidine riboswitch (type I)" /experiment="publication(s) with functional evidences, PMID:21317561, 27989440, 28096518" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21317561, 27989440, 28096518" /label="gdwB RNA" gene complement(3369206..3369308) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /label="gdwB gene" downshifts complement(3369232) /Source="Nicolas_upshifts" /id="D2015" /incds=0 /nref=194 /ntot=247 /MaxReadThrough="3.21415" /MaxDrop="5.58394" /score="-0.190335837" /energy="-10.7" /TU="U3062" /idTUdmin="U3065" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3369334..3369353) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3369345) /Source="Nicolas_upshifts" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3369347..3370088) /Source="Nicolas_S_feature" /locus_tag="new_3988981_3989722_c" /HighExp="S6, S8, S7, C30, S5, Gly, C90, Fru, BT, Pyr" /AntisenseName="yxkC" /AntisenseCor="-0.38162570069976298" /AntisenseRegPval="-10" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1491" promotor_-35 complement(3369367..3369373) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3369425..3369432 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3369445..3369463 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3369454 /Source="Nicolas_upshifts" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" S_feature 3369464..3369549 /Source="Nicolas_S_feature" /locus_tag="new_3989098_3989183" /HighExp="Cold, SMM, MG 150, GM 90, Glu, C30, GM 150, GM-0.2, GM 15, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1492" promotor_-35 3369525..3369532 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3369546..3369565 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3369551 /Source="Nicolas_upshifts" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" CDS 3369697..3370239 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818, 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391764.2" /db_xref="EnsemblGenomes-Gn:BSU38850" /db_xref="EnsemblGenomes-Tr:CAB15911" /db_xref="GOA:P94356" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12541" /db_xref="UniProtKB/Swiss-Prot:P94356" /translation="MRHKIITFILAVVVIIIIGNMIGGGGGSEATSKTSSSSKAETEK TYNIGDTVKTEKTEVTVTKVEDRDTVGTQYVEKKASEGGTIVAVQYTIKNVSKKPISS FSIPTVKLVDADGTSYDSDIDASVNYATETKVDNSKILSDLNPNIKVTGVKAFEVDKE AYAKGTWKLKFSNDVIVKIK*" /label="yxkC CDS" gene 3369697..3370239 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /label="yxkC gene" promotor_-10 complement(3370064..3370083) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3370088) /Source="Nicolas_upshifts" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3370097..3370106) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3370229 /Source="Nicolas_upshifts" /id="D2016" /incds=0 /nref=78 /ntot=276 /MaxReadThrough="4.33141" /MaxDrop="6.78221" /score="9.28209494" /energy="-14.4" /TU="U3063,U3064" /idTUdmin="U3064" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" S_feature 3370274..3370596 /Source="Nicolas_S_feature" /locus_tag="new_3989908_3990230" /HighExp="Cold, C30, Heat, Fru, Glu, C90, BMM, Glucon, M/G, Mal" /AntisenseName="galE" /AntisenseCor="0.165797390333391" /AntisenseRegPval="-2.2000000000000002" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1493" CDS complement(3370314..3371333) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /EC_number="5.1.3.7" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1906927, 9555917, 14597172" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906927, 9555917, 14597172; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 4-epimerase" /protein_id="NP_391765.1" /db_xref="EnsemblGenomes-Gn:BSU38860" /db_xref="EnsemblGenomes-Tr:CAB15912" /db_xref="GOA:P55180" /db_xref="InterPro:IPR005886" /db_xref="InterPro:IPR008089" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11837" /db_xref="UniProtKB/Swiss-Prot:P55180" /translation="MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRV KEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLT GTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILR DLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFG NDYPTKDGTGVRDYIHVVDLAEGHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFE KVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNG YKSAE*" /label="galE CDS" gene complement(3370314..3371333) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /label="galE gene" downshifts complement(3370332) /Source="Nicolas_upshifts" /id="D2017" /incds=0 /nref=235 /ntot=261 /MaxReadThrough="1.7919" /MaxDrop="7.32805" /score="24.6899971" /energy="-14.8" /TU="NA" /idTUdmin="U3066" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3371359..3371378) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3371373) /Source="Nicolas_upshifts" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3371393..3371396) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3371448..3371954) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phospholipid binding protein" /protein_id="NP_391766.1" /db_xref="EnsemblGenomes-Gn:BSU38870" /db_xref="EnsemblGenomes-Tr:CAB15913" /db_xref="InterPro:IPR005247" /db_xref="InterPro:IPR008914" /db_xref="InterPro:IPR036610" /db_xref="SubtiList:BG11899" /db_xref="UniProtKB/Swiss-Prot:P55185" /translation="MNIYVEANPYLHDKYSKYADEKYKREGNPFVSFPIHFDDIPSGA KTLALTFIDHDAIPVCGFSWIHWTAANIPAYIGELPEHASEERQDLMIQGQNSFASPL AGSNDPKVIHQYCGPTPPDKDHAYTLTVYALDAELNLQPGFYLNELYQEMKEHILAET SIELLARV*" /label="yxkA CDS" gene complement(3371448..3371954) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /label="yxkA gene" promotor_-10 complement(3371960..3371979) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3371982) /Source="Nicolas_upshifts" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3371984..3371987 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3371993..3371999) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3372002..3372021 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3372005 /Source="Nicolas_upshifts" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="upshifts" CDS 3372084..3372959 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391767.1" /db_xref="EnsemblGenomes-Gn:BSU38880" /db_xref="EnsemblGenomes-Tr:CAB15914" /db_xref="GOA:P55181" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11898" /db_xref="UniProtKB/Swiss-Prot:P55181" /translation="MDLKWLQTFIAAAESESFREAAEHLYLTQPAVSQHMRKLEDELD MRLFLHSGRRVVLTDEGRLFLPYAKEMIHVYQAGKQKVSQWKQGYSRSLTLAVHPYIA SYILPRFLPAYIQKHPHVELSTHVAGSDAIKQAVEHNEADIGLSRKDPNTNTLYYQHI CEGTLCLAAPFQESRPDAASVLTRYRLLTHDHPSYGDAFLDNIRSHYPYLQMMAVGQT DTAVHMMKAGMGASFLPTYIIKQEEAEKKLMAVSTPAHLELPASQTFMMWKRNSEDIQ HFHAMLHDFMQREQV*" /label="yxjO CDS" gene 3372084..3372959 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /label="yxjO gene" S_feature complement(3372334..3372422) /Source="Nicolas_S_feature" /locus_tag="new_3991968_3992056_c" /HighExp="GM 60, MG-0.1, MG 10, GM 5, S8, T0.30H, BC, S6, GM 15, GM 150" /AntisenseName="yxjO" /AntisenseCor="0.14032494397598999" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0669" /TUlongSig="NA" /TUlongPSig="NA" /label="S1494" downshifts complement(3372356) /Source="Nicolas_upshifts" /id="D2018" /incds=1 /nref=22 /ntot=45 /MaxReadThrough="0.10815" /MaxDrop="6.05884" /score="5.06408541" /energy="-5.6" /TU="NA" /idTUdmin="U3069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3372382..3372482) /Source="Nicolas_upshift_promotors" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3372422) /Source="Nicolas_upshifts" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="upshifts" CDS 3373037..3373510 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391768.1" /db_xref="EnsemblGenomes-Gn:BSU38890" /db_xref="EnsemblGenomes-Tr:CAB15915" /db_xref="GOA:P55182" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR020223" /db_xref="SubtiList:BG11897" /db_xref="UniProtKB/Swiss-Prot:P55182" /translation="MAMSPYIFIVLILIILSMYRERTVKPGKLLIIPLLLLWGVSASF QPAYFHSVLHVAISGILLLIGLACGFGIGKMVNVRIHPETGKVTSRGSLGSVILILVI LSLRMAARTWLPESNEMFIAIIHSMFFVPLGTITARNIMLYKAYRRLTAGKVSIQ*" /label="yxjN CDS" gene 3373037..3373510 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /label="yxjN gene" CDS 3373528..3374748 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxjL]" /protein_id="NP_391769.1" /db_xref="EnsemblGenomes-Gn:BSU38900" /db_xref="EnsemblGenomes-Tr:CAB15916" /db_xref="GOA:P55183" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11896" /db_xref="UniProtKB/Swiss-Prot:P55183" /translation="MNGQTPARHYYKKLVPSLILILNCIQFLSHPTKADPILLAFVFA VYLAFIWIIPYVASTAVSLSIFIGLWLLTDFFWAVSGQEQGAAYFLIVFLMIYAAFRL PSRLSLIFTACLIGGNILLLSSQGGSLNTIISNISIMLGLYVLFSSMRFRREARREAE RNHAELAKMHVQLEHAHKELQKAHAELQEASVLSLRYAVLEERTRIARDIHDSIGHEL TSVIVQLQSLPYILKSSKEDSEKVIQNVLSVARECLQEVRSVVHQMGRSESMVGLTAL RGLIHQVEERSGLHVSLDTAGLSEESWPPNVSETIYRILQEALTNIIRHADASHAAAV ISNDKSHLYVTITDDGQFTGSLTYGFGLTGMKERAEKAGGSLTFSAVQPSGLKIELSL PLMTTNKEQKDEQR*" /label="yxjM CDS" gene 3373528..3374748 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /label="yxjM gene" CDS 3374735..3375391 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YxjM]" /protein_id="NP_391770.1" /db_xref="EnsemblGenomes-Gn:BSU38910" /db_xref="EnsemblGenomes-Tr:CAB15917" /db_xref="GOA:P55184" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11895" /db_xref="UniProtKB/Swiss-Prot:P55184" /translation="MNKDKIRVALADDQPLVREGFRYVINAQTDMTVSGEAGDGHDII ALAKQTKPDVILMDVQMPRCSGIEAAKDIMSALPNTKIVILTTFDTEEYVFEGIRAGA VGYLLKDTLPEELIDAIRAAARGEAIFRTVTAAKIISETFRAKQQTHAEELAEPFTKR ELEVLQQMAYGLRNEDIAEKLFVSESTVKTHVHRILQKCNAQDRTQAVVFAIRNGIVQ *" /label="yxjL CDS" gene 3374735..3375391 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /label="yxjL gene" promotor_-35 3375389..3375394 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3375408..3375427 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3375411 /Source="Nicolas_upshifts" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="upshifts" CDS 3375441..3376673 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /EC_number="3.4.11.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8978088, 10987140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8978088, 10987140; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase T (tripeptidase)" /protein_id="NP_391771.1" /db_xref="EnsemblGenomes-Gn:BSU38920" /db_xref="EnsemblGenomes-Tr:CAB15918" /db_xref="GOA:P55179" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010161" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11842" /db_xref="UniProtKB/Swiss-Prot:P55179" /translation="MKEEIIERFTTYVKVDTQSDESVDTCPSTPGQLTLGNMLVDELK SIGMQDAAIDENGYVMATLPSNTEKDVPTIGFLAHVDTATDFTGKNVNPQIIESYDGK DIVLNEQLQVTLSPDQFPELSGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIKH PEIKHGTIRVAFTPDEEIGRGPHKFDVKRFNASFAYTVDGGPLGELEYESFNAAAAKI TIKGNNVHPGTAKGKMINSAKIAMKLNSLLPADEAPEYTEGYEGFYHLLSIQGDVEET KLHYIIRDFDKENFQNRKETMKRAVEELQNEYGQDRILLDMNDQYYNMREKIEPVIEI VNIAKQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISVDNM VKAVNVIVEIAKQFEAQA*" /label="pepT CDS" gene 3375441..3376673 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /label="pepT gene" downshifts complement(3375458) /Source="Nicolas_upshifts" /id="D2019" /incds=0 /nref=4 /ntot=116 /MaxReadThrough="0.86167" /MaxDrop="3.19485" /score="-2.15704435" /energy="-9.1" /TU="NA" /idTUdmin="U3069" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" downshifts 3376658 /Source="Nicolas_upshifts" /id="D2020" /incds=0 /nref=203 /ntot=244 /MaxReadThrough="3.3949" /MaxDrop="6.35116" /score="27.2051031" /energy="-13.5" /TU="U3070" /idTUdmin="U3070" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 3376719..3376728 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3376741..3376756 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3376743..3376965 /Source="Nicolas_S_feature" /locus_tag="new_3996377_3996599" /HighExp="T-0.40H, T0.30H, T0.0H, T-1.40H, T1.0H, T-1.10H, T3.30H, T2.0H, T1.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80396299999999998" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1495" upshifts 3376743 /Source="Nicolas_upshifts" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3376922 /Source="Nicolas_upshifts" /id="D2021" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="4.83682" /MaxDrop="4.66302" /score="-1.57383757" /energy="-6.2" /TU="U3071" /idTUdmin="U3070" /TUdmin=242 /isTUend="FALSE" /label="downshifts" promotor_-35 3376976..3376982 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-35" S_feature 3376995..3377095 /Source="Nicolas_S_feature" /locus_tag="new_3996629_3996729" /HighExp="Etha, Gly, Sw, Salt, B60, T0.30H, LoTm, M9-stat, T1.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1496" upshifts 3376995 /Source="Nicolas_upshifts" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="upshifts" promotor_-10 3376997..3377015 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-10" promotor_-35 3377074..3377081 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3377095..3377113 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3377097..3377194 /Source="Nicolas_S_feature" /locus_tag="new_3996731_3996828" /HighExp="Etha, T0.30H, Gly, T1.0H, Sw, Salt, T1.30H, GM 15, B60, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1497" upshifts 3377097 /Source="Nicolas_upshifts" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" CDS 3377195..3377458 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391772.1" /db_xref="EnsemblGenomes-Gn:BSU38930" /db_xref="EnsemblGenomes-Tr:CAB15919" /db_xref="GOA:P94353" /db_xref="SubtiList:BG12540" /db_xref="UniProtKB/Swiss-Prot:P94353" /translation="MLFIDLEFFEYFLAFYPYNREYQNFFWEVCNMILFIIIALCGYL LFSFSKDNRRKPQKTSPLPAAAPHHNNLIDLDAIRQKRRMHLS*" /label="yxjJ CDS" gene 3377195..3377458 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /label="yxjJ gene" promotor_-35 3377222..3377225 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3377240..3377259 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" upshifts 3377252 /Source="Nicolas_upshifts" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3377406 /Source="Nicolas_upshifts" /id="D2022" /incds=0 /nref=4 /ntot=92 /MaxReadThrough="7.33654" /MaxDrop="3.1638" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3377450 /Source="Nicolas_upshifts" /id="D2023" /incds=0 /nref=44 /ntot=188 /MaxReadThrough="5.58502" /MaxDrop="4.5161" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 3377525..3377534 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3377540 /Source="Nicolas_upshifts" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3377546..3377561 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3377587..3378075 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391773.1" /db_xref="EnsemblGenomes-Gn:BSU38940" /db_xref="EnsemblGenomes-Tr:CAB15920" /db_xref="InterPro:IPR007612" /db_xref="InterPro:IPR025659" /db_xref="SubtiList:BG12539" /db_xref="UniProtKB/Swiss-Prot:P94352" /translation="MIELFMKQKMFSFKDAFHIYDRDEQETFKVEGRFFSLGDSLQMT DSSGKTLVSIEQKLMSLLPRYEISIGGKTVCEVTKKVTFSKPKFVISGLNWEIDGDLW RDEFQLTDGENVRMSVSKKWLSWGDSYHLQIAYEEDVLICTAIAIVLDMVLYNDEDES IF*" /label="yxjI CDS" gene 3377587..3378075 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /label="yxjI gene" promotor_-35 3378080..3378087 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3378101..3378120 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3378111 /Source="Nicolas_upshifts" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3378141..3378247 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswI RNA" gene 3378141..3378247 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /label="mswI gene" downshifts 3378242 /Source="Nicolas_upshifts" /id="D2024" /incds=0 /nref=22 /ntot=102 /MaxReadThrough="7.18775" /MaxDrop="3.7896" /score="9.64734237" /energy="-14.5" /TU="U3075,U3076" /idTUdmin="U3072" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3378330..3379463 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyl-tetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391774.2" /db_xref="EnsemblGenomes-Gn:BSU38950" /db_xref="EnsemblGenomes-Tr:CAB15921" /db_xref="GOA:P42319" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11157" /db_xref="UniProtKB/Swiss-Prot:P42319" /translation="MAQQTNVAGQKTEKQRKAPFRADHVGSLLRSVPVKEARQKKAAG EMTAEQLRDIENQEITRIVEKQKEIGLDVVTDGEFRRSWWHYDFLEGLDGVEPFIPAE GIQFHNTKTKARSIKVTGKLDFTSHPALGDYQFLHEIAGNATPKLTIPSPNMLFFGEK ADKGIYDDQEEYFHDMAQAYKKAIKAFYDAGCRYLQLDDTSWSLFFEDKGREVVRALG GDPETLPAIFAKTINDAVADRPDDLTITMHICRGNFRSTWAASGGYDAVAETILDGLN LDGLFLEYDDDRSGNFDPLRFVKRKDLQIVLGLITSKYGELENPEDVKRRINEAARFV SLDQLCLSPQCGFASTEEGNLLTEEQQWAKLRHVIDIANDVWR*" /label="yxjH CDS" gene 3378330..3379463 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /label="yxjH gene" S_feature complement(3378603..3378846) /Source="Nicolas_S_feature" /locus_tag="new_3998237_3998480_c" /HighExp="dia15, Diami, H2O2, dia5, C90, Paraq, Sw, BC, LBGstat, Lbtran" /AntisenseName="yxjH" /AntisenseCor="-0.34694665046491102" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1498" promotor_-10 complement(3378841..3378860) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3378850) /Source="Nicolas_upshifts" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3378875..3378882) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3379469..3379476 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3379491..3379510 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3379497 /Source="Nicolas_upshifts" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3379532..3379638 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswJ RNA" gene 3379532..3379638 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /label="mswJ gene" downshifts 3379585 /Source="Nicolas_upshifts" /id="D2025" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="8.35488" /MaxDrop="3.50346" /score="29.0146782" /energy="-14.5" /TU="U3075,U3076,U3078" /idTUdmin="U3075" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 3379639..3379715 /Source="Nicolas_S_feature" /locus_tag="new_3999273_3999349" /HighExp="MG 5, MG t5, T1.0H, MG 10, T1.30H, BMM, T0.30H, T-0.40H, T0.0H, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigD, SigB, SigWXY" /TUlongPSig="0.554, 1, 1, 1" /label="S1499" CDS 3379716..3380852 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254, 21749987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391775.3" /db_xref="EnsemblGenomes-Gn:BSU38960" /db_xref="EnsemblGenomes-Tr:CAB15922" /db_xref="GOA:P42318" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11156" /db_xref="UniProtKB/Swiss-Prot:P42318" /translation="MSQQTTPAEQKSLQRKKPPFRADQVGSLLRSEPVKKARLQKAAG EMTAEQLRQIENDEIIRIVEKQKETGLNVVTDGEFRRAWWHFDFLENLDGVEPFTPEQ GIQFHNVQTKARGIKVTGDIDFSTHPMLEDYSFLHSIAGDATPKMTIPSPNMLFFRGK LEKDEYKNDYQLFQHDVSKAYKKAIQAFYDRGCRYLQLDDTAWAVFLSEKGLKQIEAF GTTPDELRQLFAKSINDAIADRPDDLTVTMHICRGNFQSTWTAEGGYDAAAETIFDGL NLDGLFLEYDDSRSGGFEPLRYVKRSDLQLVLGLVTSKFGELENPDDVKRRIEEASRY VSLDQLCLSPQCGFASTEEGNKLTEEQQWAKLRHVVEIANDVWK*" /label="yxjG CDS" gene 3379716..3380852 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /label="yxjG gene" downshifts 3380839 /Source="Nicolas_upshifts" /id="D2026" /incds=0 /nref=81 /ntot=187 /MaxReadThrough="4.24668" /MaxDrop="5.8124" /score="11.1243305" /energy="-12.8" /TU="U3076,U3078" /idTUdmin="U3075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3380905..3381678) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacid dehydrogenase" /protein_id="NP_391776.2" /db_xref="EnsemblGenomes-Gn:BSU38970" /db_xref="EnsemblGenomes-Tr:CAB15923" /db_xref="GOA:P42317" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011294" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11155" /db_xref="UniProtKB/Swiss-Prot:P42317" /translation="MRKQVALVTGAAGGIGFEIAREFAREGASVIVSDLRPEACEKAA SKLAEEGFDAAAIPYDVTKEAQVADTVNVIQKQYGRLDILVNNAGIQHVAPIEEFPTD TFEQLIKVMLTAPFIAMKHVFPIMKKQQFGRIINIASVNGLVGFAGKSAYNSAKHGVI GLTKVGALEGAPHGITVNALCPGYVDTQLVRNQLSDLSKTRNVPYDSVLEQVIFPLVP QKRLLSVKEIADYAVFLASEKAKGVTGQAVVLDGGYTAQ*" /label="yxjF CDS" gene complement(3380905..3381678) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /label="yxjF gene" downshifts complement(3380915) /Source="Nicolas_upshifts" /id="D2027" /incds=0 /nref=23 /ntot=63 /MaxReadThrough="0.65" /MaxDrop="6.97604" /score="24.6585594" /energy="-12.8" /TU="NA" /idTUdmin="U3079" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3381695..3382345) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit B)" /protein_id="NP_391777.1" /db_xref="EnsemblGenomes-Gn:BSU38980" /db_xref="EnsemblGenomes-Tr:CAB15924" /db_xref="GOA:P42316" /db_xref="InterPro:IPR004164" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11154" /db_xref="UniProtKB/Swiss-Prot:P42316" /translation="MKEARKRMVKRAVQEIKDGMNVNLGIGMPTLVANEIPDGVHVML QSENGLLGIGPYPLEGTEDADLINAGKETITEVTGASYFDSAESFAMIRGGHIDLAIL GGMEVSEQGDLANWMIPGKMVKGMGGAMDLVNGAKRIVVIMEHVNKHGESKVKKTCSL PLTGQKVVHRLITDLAVFDFVNGRMTLTELQDGVTIEEVYEKTEADFAVSQSVLNS*" /label="scoB CDS" gene complement(3381695..3382345) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /label="scoB gene" CDS complement(3382342..3383058) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit A)" /protein_id="NP_391778.1" /db_xref="EnsemblGenomes-Gn:BSU38990" /db_xref="EnsemblGenomes-Tr:CAB15925" /db_xref="GOA:P42315" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11153" /db_xref="UniProtKB/Swiss-Prot:P42315" /translation="MGKVLSSSKEAAKLIHDGDTLIAGGFGLCGIPEQLILSIRDQGV KDLTVVSNNCGVDDWGLGLLLANKQIKKMIASYVGENKIFERQFLSGELEVELVPQGT LAERIRAGGAGIPGFYTATGVGTSIAEGKEHKTFGGRTYVLERGITGDVAIVKAWKAD TMGNLIFRKTARNFNPIAAMAGKITIAEAEEIVEAGELDPDHIHTPGIYVQHVVLGAS QEKRIEKRTVQQASGKGEAK*" /label="scoA CDS" gene complement(3382342..3383058) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /label="scoA gene" CDS complement(3383082..3384500) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative acid metabolite permease" /protein_id="NP_391779.3" /db_xref="EnsemblGenomes-Gn:BSU39000" /db_xref="EnsemblGenomes-Tr:CAB15926" /db_xref="GOA:P42314" /db_xref="SubtiList:BG11152" /db_xref="UniProtKB/Swiss-Prot:P42314" /translation="MELIIILLALGLLMFTAYRGFSVILFAPICALFAVLLTDPSHVL PFFSSIFMEKMAGFIKLYFPVFLLGAIFGKVVEMAGLAASIAKTIVRLVGAKRAILAI VLMGAVLTYSGVSLFVVVFAVYPFAKNMFQEANIPKRLIPGTIALGAFTFTMDALPGT PQIQNVIPTSFFKTDIYAAPWLGLMGAVIVLAAGMLYLESRRKKAQASGEGYGGFDSQ NAPAPESIESAAEPDKSPIRHALAFVPLILVGAVNKYFTIYLPKWYPNGFDFSSIGLK EFGRLDISSAAAIWSVEIALVIGIITTILFDWRSVFAQLKEGLNEGIGGALLASMNTG AEYGFGGIIAALPGFHKLSSGISHTFTDPLVNGAVTTTALAGITGSASGGMGIALSAM SEQYLQAIQAYNIPPEVMHRVISMASGGMDTLPHNGAVITLLAVTGLTHRQSYRDIFA ITLIKTAAVFAVIAIYSLTGLV*" /label="yxjC CDS" gene complement(3383082..3384500) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /label="yxjC gene" promotor_-10 complement(3383668..3383686) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3383687) /Source="Nicolas_upshifts" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3383702..3383707) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3384501..3384585) /Source="Nicolas_S_feature" /locus_tag="new_4004135_4004219_c" /HighExp="S5, S4, S6, S3, S7, M9-stat, B60, S8, T4.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1500" promotor_-10 complement(3384569..3384587) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3384585) /Source="Nicolas_upshifts" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3384603..3384608) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3384654..3385502) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /EC_number="2.1.1.188" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11967079, 14999102, 18406425, 23716046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m(1)G748 methyltransferase (class II)" /protein_id="NP_391780.1" /db_xref="EnsemblGenomes-Gn:BSU39010" /db_xref="EnsemblGenomes-Tr:CAB15927" /db_xref="GOA:P42313" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR016718" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11151" /db_xref="UniProtKB/Swiss-Prot:P42313" /translation="MKRTVDFSMFRCPLCDSSMDAASGKSLICTERGHTFDLSRHGYV NFLTKPVKTSYGAELFEARSRLIGECGFFDPLHDAIAELISHPKSGHEAFTILDSGCG EGSHLNALCGFDYAGKAAIGTGIDLSKDGILKASKAFKDLMWAVADVARAPFHDRQFD VVLSIFSPSNYAEFHRLLKNDGMLIKVVPRSDYLIELRQFLYTDSPRRTYSNTAAVER FTANAAHSRPVRLRYVKTLDQQAIHWLLKMTPLAWSAPKDRVSLLKEMKSADITVDVD ILIGMK*" /label="rlmA CDS" gene complement(3384654..3385502) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /label="rlmA gene" downshifts complement(3384664) /Source="Nicolas_upshifts" /id="D2028" /incds=0 /nref=54 /ntot=218 /MaxReadThrough="1.618" /MaxDrop="4.63737" /score="17.0758624" /energy="-15.1" /TU="NA" /idTUdmin="U3081" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(3385503..3385688) /Source="Nicolas_S_feature" /locus_tag="new_4005137_4005322_c" /HighExp="B60, LBGstat, LPhT, M9-stat, C30, T0.30H, HPh, Oxctl, Heat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1501" promotor_-10 complement(3385677..3385696) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3385688) /Source="Nicolas_upshifts" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3385690..3386415) /Source="Nicolas_S_feature" /locus_tag="new_4005324_4006049_c" /HighExp="LBGstat, C30, GM 25, Heat, GM 10, GM 45, GM 60, GM 90, T0.30H, GM 120" /AntisenseName="NA" /AntisenseCor="0.20859849915331599" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1502" promotor_-35 complement(3385712..3385716) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3385850..3385857 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3385870..3385889 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3385879 /Source="Nicolas_upshifts" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3385889..3385991 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswB RNA" gene 3385889..3385991 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /label="gswB gene" S_feature 3385992..3386095 /Source="Nicolas_S_feature" /locus_tag="new_4005626_4005729" /HighExp="C90, G180, M40t45, dia15, LBGexp, Lbexp, Lbtran, G135, Mt0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1503" promotor_-35 3386067..3386073 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3386087..3386098 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3386097 /Source="Nicolas_upshifts" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="upshifts" CDS 3386118..3387311 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12787499, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="purine nucleoside transporter" /protein_id="NP_391781.2" /db_xref="EnsemblGenomes-Gn:BSU39020" /db_xref="EnsemblGenomes-Tr:CAB15928" /db_xref="GOA:P42312" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG11150" /db_xref="UniProtKB/Swiss-Prot:P42312" /translation="MYFLLNLVGLIVIMAVVFLCSPQKKKIKWRPIITLIVLELLITW FMLGTKVGSWAIGKIGDFFTWLIACASDGIAFAFPSVMANETVDFFFSALLPIIFIVT FFDILTYFGILPWLIDKIGWVISKASRLPKLESFFSIQMMFLGNTEALAVIRQQLTVL SNNRLLTFGLMSMSSISGSIIGSYLSMVPATYVFTAIPLNCLNALIIANLLNPVHVPE DEDIIYTPPKEEKKDFFSTISNSMLVGMNMVIVILAMVIGYVALTSAVNGILGVFVHG LTIQTIFAYLFSPFAFLLGLPVHDAMYVAQLMGMKLATNEFVAMLDLKNNLKSLPPHT VAVATTFLTSFANFSTVGMIYGTYNSILDGEKSTVIGRNVWKLLVSGIAVSLLSAAIV GLFVW*" /label="nupG CDS" gene 3386118..3387311 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /label="nupG gene" promotor_-10 complement(3386402..3386420) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3386418) /Source="Nicolas_upshifts" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3386433..3386440) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3387087 /Source="Nicolas_upshifts" /id="D2029" /incds=1 /nref=1 /ntot=58 /MaxReadThrough="5.88279" /MaxDrop="2.4159" /score="8.04757856" /energy="-16.6" /TU="U3082,U3083" /idTUdmin="U3082" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" downshifts 3387307 /Source="Nicolas_upshifts" /id="D2030" /incds=0 /nref=71 /ntot=204 /MaxReadThrough="2.7474" /MaxDrop="4.05925" /score="8.04757856" /energy="-16.6" /TU="NA" /idTUdmin="U3082" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3387353..3387781) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminus)" /translation="KTKKQANSRALKREYQTSFSVKYNAAGKLSIQTLNYIYSGGAHG LTSVQSFNYDLKAQKRVTLDQILNTKTKVSKTRDYLYSYIKKHDVLFFSDVKKEDITL NRDTMFYFTANGIAIVFGQYDLGPYAAGIRDVQVPASIYQ*" /label="yxiTc CDS" gene complement(3387353..3387781) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /pseudo /label="yxiTc gene" CDS complement(3387782..3388024) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (N-terminus)" /db_xref="PSEUDO:CAB15929.2" /db_xref="SubtiList:BG11149" /db_xref="UniProtKB/Swiss-Prot:P42311" /translation="MKWNNMLKAAGIAVLLFSVFAYAAPSLKAVQAKTPTVSTHTYKK IKELTYPQVHHVGNAAFEKKINQELKAYMNNRIRNT*" /label="yxiTn CDS" gene complement(3387782..3388024) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /pseudo /label="yxiTn gene" S_feature complement(3388025..3388088) /Source="Nicolas_S_feature" /locus_tag="new_4007659_4007722_c" /HighExp="T2.30H, S6, Etha, T3.30H, S5, BT, T3.0H, T4.0H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.942" /TUlongSig="NA" /TUlongPSig="NA" /label="S1504" promotor_-10 complement(3388077..3388092) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3388088) /Source="Nicolas_upshifts" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3388104..3388113) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3388121 /Source="Nicolas_upshifts" /id="D2031" /incds=0 /nref=10 /ntot=69 /MaxReadThrough="0.814549999999999" /MaxDrop="3.89525" /score="14.5338714" /energy="-6.9" /TU="NA" /idTUdmin="U3082" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(3388169..3388459) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391783.2" /db_xref="EnsemblGenomes-Gn:BSU39040" /db_xref="EnsemblGenomes-Tr:CAB15930" /db_xref="SubtiList:BG11148" /db_xref="UniProtKB/Swiss-Prot:P42310" /translation="MNEKQLTEAYERDENMMILVFAQWCVNHDLDPMELYAKAYPQQK LNESLKKTMDDLVVPKHEAEHIPDQTVIAVLEMFGNTDLAQALHEAISGRKQ*" /label="yxiS CDS" gene complement(3388169..3388459) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /label="yxiS gene" downshifts complement(3388175) /Source="Nicolas_upshifts" /id="D2032" /incds=0 /nref=168 /ntot=241 /MaxReadThrough="3.10756" /MaxDrop="6.10709" /score="16.5130207" /energy="-6.9" /TU="NA" /idTUdmin="U3086" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3388484..3388503) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3388501) /Source="Nicolas_upshifts" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3388509..3390569) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7559348, 8931328, 16151211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559348, 8931328, 16151211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catalase 2" /protein_id="NP_391784.2" /db_xref="EnsemblGenomes-Gn:BSU39050" /db_xref="EnsemblGenomes-Tr:CAB15931" /db_xref="GOA:P42234" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024712" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11102" /db_xref="UniProtKB/Swiss-Prot:P42234" /translation="MSDDQNKRVNEHSKDEQLEQYRTDNSGKKMTTNQGLRVSEDEHS LKAGVRGPTLMEDFHFREKMTHFDHERIPERVVHARGFGVHGFFQVYEPMTEYTRAKF LQDPSVKTPVFVRFSTVAGSKGSADTVRDARGFATKFYTEEGNYDLVGNNIPVFFIQD AIKFPDLVHAFKPEPHNEMPQAATAHDTFWDFVANNPESAHMVMWTMSDRGIPRSYRM MEGFGVHTFRFVNEQGKARFVKFHWKPVLGVHSLVWDEAQKIAGKDPDFHRRDLWETI ENGGKVEYELGVQMIDEEDEFKFDFDILDPTKLWPEELVPVKIIGKMTLNRNQDNVFA ETEQVAFHPGNVVPGIDFTNDPLLQGRLFSYTDTQLIRLGGPNFHEIPINRPVCPFHN NQYDGYHRMTINKGPVAYHKNSLQNNDPSPATAEEGGYVHYQEKVEGKKIRQRSDSFN DYYSQAKLFWNSMSPVEKQHIISAFCFEVGKVKSKDVQRQVVDVFSNVDADLAEEIAK GVGVAAPAKRKASKEILTSPALSQARTVKTASTRKVAVLAGNGFHEKELQTVLEALKQ EGITVDIISQNLGYMTSGSGQQLEASGTFLTVDSVLYDAVYAAGGLELKDNKQAMAFI REAYNHYKAIGAANEGIDLLQSSVGTTEGLGIVTAKDEPDYTAFSKAFIDAVAAHRHW DRRI*" /label="katE CDS" gene complement(3388509..3390569) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /label="katE gene" promotor_-35 complement(3388517..3388524) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3390598..3390616) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3390602) /Source="Nicolas_upshifts" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3390631..3390637) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3390662..3390667 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3390681 /Source="Nicolas_upshifts" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3390683..3390701 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3390695..3390769 /Source="Nicolas_S_feature" /locus_tag="new_4010329_4010403" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, LoTm, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1505" CDS 3390770..3392050 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8892821, 11053381, 15849754, 16850406, 18556792" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8892821, 11053381, 15849754, 16850406, 18556792; Product type t : transporter" /codon_start=1 /transl_table=11 /product="secondary transporter of divalent metal ions/citrate complexes" /protein_id="NP_391785.2" /db_xref="EnsemblGenomes-Gn:BSU39060" /db_xref="EnsemblGenomes-Tr:CAB15932" /db_xref="GOA:P42308" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11146" /db_xref="UniProtKB/Swiss-Prot:P42308" /translation="MLAILGFVMMIVFMYLIMSNRLSALIALIVVPIVFALISGFGKD LGEMMIQGVTDLAPTGIMLLFAILYFGIMIDSGLFDPLIAKILSFVKGDPLKIAVGTA VLTMTISLDGDGTTTYMITIAAMLPLYKRLGMNRLVLAGIAMLGSGVMNIIPWGGPTA RVLASLKLDTSEVFTPLIPAMIAGILWVIAVAYILGKKERKRLGVISIDHAPSSDPEA APLKRPALQWFNLLLTVALMAALITSLLPLPVLFMTAFAVALMVNYPNVKEQQKRISA HAGNALNVVSMVFAAGIFTGILSGTKMVDAMAHSLVSLIPDAMGPHLPLITAIVSMPF TFFMSNDAFYFGVLPIIAEAASAYGIDAAEIGRASLLGQPVHLLSPLVPSTYLLVGMA GVSFGDHQKFTIKWAVGTTIVMTIAALLIGIISF*" /label="citH CDS" gene 3390770..3392050 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /label="citH gene" S_feature 3392051..3392190 /Source="Nicolas_S_feature" /locus_tag="new_4011685_4011824" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, BT, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.382965" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1506" downshifts 3392147 /Source="Nicolas_upshifts" /id="D2033" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.69139" /MaxDrop="3.50434" /score="10.8797157" /energy="-9" /TU="NA" /idTUdmin="U3088" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3392208..3392936) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /EC_number="3.2.1.73" /EC_number="3.2.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1369198, 3106158, 7704256, 20600285, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1369198, 3106158, 7704256, 20600285, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,3-1,4 glucanase" /protein_id="NP_391786.1" /db_xref="EnsemblGenomes-Gn:BSU39070" /db_xref="EnsemblGenomes-Tr:CAB15943" /db_xref="GOA:P04957" /db_xref="InterPro:IPR000757" /db_xref="InterPro:IPR008263" /db_xref="InterPro:IPR008264" /db_xref="InterPro:IPR013320" /db_xref="PDB:3O5S" /db_xref="SubtiList:BG10476" /db_xref="UniProtKB/Swiss-Prot:P04957" /translation="MPYLKRVLLLLVTGLFMSLFAVTATASAQTGGSFFDPFNGYNSG FWQKADGYSNGNMFNCTWRANNVSMTSLGEMRLALTSPAYNKFDCGENRSVQTYGYGL YEVRMKPAKNTGIVSSFFTYTGPTDGTPWDEIDIEFLGKDTTKVQFNYYTNGAGNHEK IVDLGFDAANAYHTYAFDWQPNSIKWYVDGQLKHTATNQIPTTPGKIMMNLWNGTGVD EWLGSYNGVNPLYAHYDWVRYTKK*" /label="bglS CDS" gene complement(3392208..3392936) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /label="bglS gene" downshifts complement(3392225) /Source="Nicolas_upshifts" /id="D2034" /incds=0 /nref=64 /ntot=139 /MaxReadThrough="1.52649" /MaxDrop="6.38109" /score="-8.35070051" /energy="-16.3" /TU="NA" /idTUdmin="U3089" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3392967..3392986) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3392978) /Source="Nicolas_upshifts" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3393000..3393007) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3393124..3393231) /Source="Nicolas_S_feature" /locus_tag="new_4012758_4012865_c" /HighExp="Sw, LPhT, T0.30H, M0t90, M9-stat, M40t90, Lbtran, Lbstat, S2, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1507" downshifts complement(3393167) /Source="Nicolas_upshifts" /id="D2035" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="3.35114" /MaxDrop="4.38508" /score="-8.35070051" /energy="-16.3" /TU="U3090,U3091" /idTUdmin="U3091" /TUdmin="-174" /isTUend="FALSE" /label="downshifts" CDS complement(3393232..3394065) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_391787.2" /db_xref="EnsemblGenomes-Gn:BSU39080" /db_xref="EnsemblGenomes-Tr:CAB15944" /db_xref="GOA:P39805" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1H99" /db_xref="PDB:1L1C" /db_xref="PDB:1TLV" /db_xref="SubtiList:BG10474" /db_xref="UniProtKB/Swiss-Prot:P39805" /translation="MKIAKVINNNVISVVNEQGKELVVMGRGLAFQKKSGDDVDEARI EKVFTLDNKDVSEKFKTLLYDIPIECMEVSEEIISYAKLQLGKKLNDSIYVSLTDHIN FAIQRNQKGLDIKNALLWETKRLYKDEFAIGKEALVMVKNKTGVSLPEDEAGFIALHI VNAELNEEMPNIINITKVMQEILSIVKYHFKIEFNEESLHYYRFVTHLKFFAQRLFNG THMESQDDFLLDTVKEKYHRAYECTKKIQTYIEREYEHKLTSDELLYLTIHIERVVKQ A*" /label="licT CDS" gene complement(3393232..3394065) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /label="licT gene" promotor_-10 complement(3394096..3394115) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3394115) /Source="Nicolas_upshifts" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3394129..3394136) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3394161..3394841) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391788.1" /db_xref="EnsemblGenomes-Gn:BSU39090" /db_xref="EnsemblGenomes-Tr:CAB15945" /db_xref="SubtiList:BG11145" /db_xref="UniProtKB/Swiss-Prot:P42307" /translation="MRRIGLCISLLVTVLVMSACESEGEAQMFADCDQKTVKQTAAKP MSSKKKQDFQALASDRQLAIVFSSMIQVSEAFDYGIGNPEYFVRISMTEEEADIAKEN LESIKLENKSLKKQNSEAVALLQKTRNQDMSRIEIQQLTENRAGFFETADSMIKLINQ VTPKNAKKTRQQLDQLKKQYTQYSAESIKIMNSIVKKQKADKASFERHLEALLQKQPG QQVRSELY*" /label="yxiP CDS" gene complement(3394161..3394841) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /label="yxiP gene" promotor_-10 complement(3394888..3394907) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-10" upshifts complement(3394897) /Source="Nicolas_upshifts" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="upshifts" promotor_-35 complement(3394921..3394928) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-35" promotor_-35 3394989..3394992 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3395007..3395026 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3395007 /Source="Nicolas_upshifts" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="upshifts" CDS 3395048..3396334 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12583894, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391789.1" /db_xref="EnsemblGenomes-Gn:BSU39100" /db_xref="EnsemblGenomes-Tr:CAB15946" /db_xref="GOA:P42306" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024671" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11144" /db_xref="UniProtKB/Swiss-Prot:P42306" /translation="MMKRFTKQENSWVLYDWANSAYSIVVTTAVFPLFYKSAAAESGV SAAQSTAYLGYTIAISTFILAMLGPILGTIADYEGCKKKFFGFFVSAGVASTAMLAFI PSEHWLLLLLFYTVSAIGFSGANVFYDAFLVDVTPEKRMNLVSARGFGLGYIGSTIPF IISIAVILLAQAETIPVSVSAASQLSFFITAAWWGLFTIPMIKHVHQRYYIKKEPHIV INSFKRLGQTMKRIRQYRALFLFLLAYFFYIDGVGTIITMSTSYGSDLGIGSSSLLII LFVTQVVAAPFSIIYGKLAERFTGKTMLYVGIVIYMIVCVYAYFMETTLDFWILAMLV ATSQGGIQALSRSYFAKLVPKRHANEFFGFYNIFGKFASIMGPLLIAVTAQLTGKSST AVFSLIILFVIGIVILAFVPEETSTDVSQQQNDLPL*" /label="yxiO CDS" gene 3395048..3396334 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /label="yxiO gene" promotor_-10 complement(3395779..3395797) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3395787) /Source="Nicolas_upshifts" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3395811..3395818) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3396305 /Source="Nicolas_upshifts" /id="D2036" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="2.50578" /MaxDrop="3.06646" /score="-7.45683354" /energy="-16.7" /TU="NA" /idTUdmin="U3092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3396353..3397792) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase for 23S ribosomal RNAmaturation" /protein_id="NP_391790.2" /db_xref="EnsemblGenomes-Gn:BSU39110" /db_xref="EnsemblGenomes-Tr:CAB15947" /db_xref="GOA:P42305" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005580" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028619" /db_xref="PDB:2G0C" /db_xref="PDB:2HJV" /db_xref="PDB:3MOJ" /db_xref="SubtiList:BG11143" /db_xref="UniProtKB/Swiss-Prot:P42305" /translation="MSHFKNYQISHDILRALEGLGYTEPTKVQQSVIPAALERKDLVV KSQTGSGKTASFGIPLCELANWDENKPQALILTPTRELAVQVKEDITNIGRFKRIKAT AVFGKSSFDKQKAELKQKSHIVVGTPGRVLDHIEKGTLPLDRLSYLVIDEADEMLNMG FIEQVEAIIKHLPTERTTMLFSATLPQDIEKLSRQYMQNPEHIEVKAAGLTTRNIEHA VIQVREENKFSLLKDVLMTENPDSCIIFCRTKEHVNQLTDELDDLGYPCDKIHGGMIQ EDRFDVMNEFKRGEYRYLVATDVAARGIDIENISLVINYDLPLEKESYVHRTGRTGRA GNKGKAISFVTAFEKRFLADIEEYIGFEIQKIEAPSQEEVARKKPEFLAKLNDRPESK KDKSEELNKDIMKLYFNGGKKKKIRAVDFVGTIAKIDGVSADDIGIITIMDNASYVEI LNGKGPHVLKVMKNTTVKGKQLKVNKANK*" /label="deaD CDS" gene complement(3396353..3397792) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /label="deaD gene" downshifts complement(3396376) /Source="Nicolas_upshifts" /id="D2037" /incds=0 /nref=200 /ntot=269 /MaxReadThrough="1.50578" /MaxDrop="5.83238" /score="3.28924902" /energy="-18.2" /TU="NA" /idTUdmin="U3095" /TUdmin=5 /isTUend="TRUE" /label="downshifts" misc_feature complement(3397816..3397835) /Source="Nicolas_upshift_promotors" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3397833) /Source="Nicolas_upshifts" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3397874..3399022) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10746760, 25394512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="esterase (lipoprotein)" /protein_id="NP_391791.2" /db_xref="EnsemblGenomes-Gn:BSU39120" /db_xref="EnsemblGenomes-Tr:CAB15948" /db_xref="GOA:P42304" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="PDB:2O14" /db_xref="SubtiList:BG11142" /db_xref="UniProtKB/Swiss-Prot:P42304" /translation="MKKWMAAVFVMMLMLCFGGIENVKAAEPKVYQFDFGSGSMEPGY IGVRASDRYDRSKGYGFQTPENMRDVAASGAGVKSDAVQFLAYGTKSNNTFNVDLPNG LYEVKVTLGNTARASVAAEGVFQVINMTGDGAEDTFQIPVTDGQLNLLVTEGKAGTAF TLSALKIKKLSDQPVTNRTIYVGGDSTVCNYYPLNSSKQAGWGQMLPHYIDKHTFQVR NMASGGQIARGFRNDGQLEAILKYIKPGDYFMLQLGINDTNPKHKESEAEFKEVMRDM IRQVKAKGADVILSTPQGRATDFTSEGIHSSVNRWYRASILALAEEEKTYLIDLNVLS SAYFTSIGPERTLGLYMDGDTLHPNRAGADALARLAVQELKRQGIAGF*" /label="yxiM CDS" gene complement(3397874..3399022) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /label="yxiM gene" promotor_-10 complement(3399049..3399065) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3399065) /Source="Nicolas_upshifts" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3399067..3399151) /Source="Nicolas_S_feature" /locus_tag="new_4018701_4018785_c" /HighExp="T3.30H, T4.0H, T2.30H, T3.0H, T2.0H, T-3.40H, T5.0H, T-2.40H, Lbexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1508" promotor_-35 complement(3399080..3399085) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3399152..3399340) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52710.1" /translation="MRFENISASKLDDLESIDSVALEIVPTDDQWERLRYYVYDEENQ ISFYCGGWDVIKCDKKSH*" /label="yxzI CDS" gene complement(3399152..3399340) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /pseudo /label="yxzI gene" CDS complement(3399371..3399502) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097796.1" /db_xref="EnsemblGenomes-Gn:BSU39139" /db_xref="EnsemblGenomes-Tr:CAX52711" /db_xref="UniProtKB/Swiss-Prot:C0H3T5" /translation="MNITQYEKLKQHLSDEDTGPFTLNEFSFYMKEDDRYIHIPVFE* " /label="yxzJ CDS" gene complement(3399371..3399502) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /label="yxzJ gene" CDS complement(3399514..3399975) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type f: factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391793.1" /db_xref="EnsemblGenomes-Gn:BSU39140" /db_xref="EnsemblGenomes-Tr:CAB15950" /db_xref="SubtiList:BG11140" /db_xref="UniProtKB/Swiss-Prot:P42302" /translation="MEITSISSIGNLDMIELKPDQTVMACELEDAESFYRFWAGLAYD RIMIQVITTGSFIEDLSEYFEGHAYKVTKLAKREFHFQSILQEADRDIADFLFLLASI NDDVFLITDPQPDKSYFSEGKLQCLTDSGERIIWFEYDAVDIYMIGGESYK*" /label="yxiK CDS" gene complement(3399514..3399975) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /label="yxiK gene" CDS complement(3399991..3400287) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391794.1" /db_xref="EnsemblGenomes-Gn:BSU39150" /db_xref="EnsemblGenomes-Tr:CAB15951" /db_xref="InterPro:IPR025551" /db_xref="SubtiList:BG11139" /db_xref="UniProtKB/Swiss-Prot:P42320" /translation="MLQKLRKRQRELEEKQYPDELYGFEAEIYEFFMLVAGSLDYVLA NKRIPRHQRRSLEKSFFELYPDILPDMIKNDKDLYHHILLYEQVRQEICVALSN*" /label="yxiJ CDS" gene complement(3399991..3400287) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /label="yxiJ gene" CDS complement(3400315..3400803) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391795.1" /db_xref="EnsemblGenomes-Gn:BSU39160" /db_xref="EnsemblGenomes-Tr:CAB15952" /db_xref="InterPro:IPR020323" /db_xref="SubtiList:BG11138" /db_xref="UniProtKB/Swiss-Prot:P42301" /translation="MMNWRALSQTKQDRIWSEVNKIIKWKPGSRCHHIIPPDPYRVFD ISSAMSSKAGHNDVSGVLSDLETSILKAFQLGTGKNDVMYALDWQHDGYTFSPHQAMP KDEFGEWPVPVFPNGDYYFFFHQDFSWGLLGDPWKCAITVFGEELLEAIDNDPPILFR NK*" /label="yxiI CDS" gene complement(3400315..3400803) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /label="yxiI gene" CDS complement(3400821..3401273) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391796.1" /db_xref="EnsemblGenomes-Gn:BSU39170" /db_xref="EnsemblGenomes-Tr:CAB15953" /db_xref="SubtiList:BG14170" /db_xref="UniProtKB/Swiss-Prot:O32285" /translation="MWCFTLDGQQKEIHIDRKLEEMDAPAVDDCYGLAEKNGLIYMLY YGDAVIAAFDETVVRRVWILSDKEPDSEAFDQLAISEEGFLVGTFNCYSADLKSSLYL ISADVSQEMEEITCCDSNGEGLDVQQLKLTSYAVYAVASSGVYKQDIQ*" /label="yxzG CDS" gene complement(3400821..3401273) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /label="yxzG gene" S_feature complement(3401274..3401342) /Source="Nicolas_S_feature" /locus_tag="new_4020908_4020976_c" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, T2.0H, T-3.40H, T5.0H, T-2.40H, T-4.40H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19384199999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1509" CDS complement(3401343..3401672) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391797.1" /db_xref="EnsemblGenomes-Gn:BSU39180" /db_xref="EnsemblGenomes-Tr:CAB15954" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11137" /db_xref="UniProtKB/Swiss-Prot:P42300" /translation="MKKLKLNKIINENTQDCFFHADPQGRVYIGKGLKGGITITIYDP SGDVRDFRVKEQISYSDILLFQQCADGYVFVYYESYEPKVKVFSEEGRVKSVFHLPSG VSCCLLD*" /label="yxiH CDS" gene complement(3401343..3401672) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /label="yxiH gene" S_feature complement(3401673..3401794) /Source="Nicolas_S_feature" /locus_tag="new_4021307_4021428_c" /HighExp="T3.30H, T4.0H, T3.0H, T2.30H, T-4.40H, T-3.40H, LBGexp, T-2.40H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1510" CDS complement(3401795..3402211) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391798.1" /db_xref="EnsemblGenomes-Gn:BSU39190" /db_xref="EnsemblGenomes-Tr:CAB15955" /db_xref="SubtiList:BG11136" /db_xref="UniProtKB/Swiss-Prot:P42299" /translation="MTMYQTINEWVDYIDKGCSVLHLDFNVFKKELSLDIKVFEDEGE YTHKISFQNVASAYYSADVGDMRLEKIDPEEYNWQVFEMSYHPEGIGNLSNSIIPEYQ SNANFLIDMNRMLIAIEAETVRFDDQSFYAYQLNTK*" /label="yxiG CDS" gene complement(3401795..3402211) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /label="yxiG gene" CDS complement(3402262..3402630) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391799.1" /db_xref="EnsemblGenomes-Gn:BSU39200" /db_xref="EnsemblGenomes-Tr:CAB15956" /db_xref="SubtiList:BG14167" /db_xref="UniProtKB/Swiss-Prot:O32286" /translation="MVDWKPFGTYLLRKKLQYLNISTVLCILIKNHLVLEYVVIKLSE TNLIECINKIKSVLNGQTTREEVSDWAGTYVYADDPEVEDDRVWDMLILLSGIDLKDS SETYLHSTDDLNDWIKQYTE*" /label="yxzC CDS" gene complement(3402262..3402630) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /label="yxzC gene" CDS complement(3402624..3403094) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391800.1" /db_xref="EnsemblGenomes-Gn:BSU39210" /db_xref="EnsemblGenomes-Tr:CAB15957" /db_xref="SubtiList:BG11135" /db_xref="UniProtKB/Swiss-Prot:P42298" /translation="MQKRLIEKLAENKRRLLMSEIKEKLVPCAERGFTYRFADLAQSR QLLELVLSNSIPANTREVDALEKTEAKQLIWKISQSYVAYDDRDVLLFHQYSSEIGAL VCSFGKCLEHLDCLLECIEFDEGILNHSFILVEPKCQFGLCILHTEYGCELVYW*" /label="yxiF CDS" gene complement(3402624..3403094) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /label="yxiF gene" S_feature complement(3403095..3403419) /Source="Nicolas_S_feature" /locus_tag="new_4022729_4023053_c" /HighExp="T3.30H, T-2.40H, T2.30H, T3.0H, T4.0H, SMMPr, MG 120, C90, T2.0H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1511" CDS complement(3403420..3403848) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /experiment="publication(s) with functional evidences, PMID:1529529, 16306698, 19763274, 23572593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1529529, 16306698, 19763274, 23572593; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin of WapA tRNase" /protein_id="NP_391801.1" /db_xref="EnsemblGenomes-Gn:BSU39220" /db_xref="EnsemblGenomes-Tr:CAB15958" /db_xref="SubtiList:BG10798" /db_xref="UniProtKB/Swiss-Prot:Q07836" /translation="MAKIKDDCIELELTPRRYQELDDDPFILSVFELLENKKAVVRDF SAVLLESEYKVLISGIETMIKGNQDSISLETIEPFLFLSIDQENGNYRIKIKIIFDDY KESKSNSNLFEINCNEEKLESFVTALKLNLENTKNPSKLP*" /label="wapI CDS" gene complement(3403420..3403848) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /label="wapI gene" CDS complement(3403910..3410914) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated tRNA nuclease precursor; intercellular growth inhibitor" /protein_id="NP_391802.2" /db_xref="EnsemblGenomes-Gn:BSU39230" /db_xref="EnsemblGenomes-Tr:CAB15959" /db_xref="GOA:Q07833" /db_xref="InterPro:IPR006530" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR022385" /db_xref="InterPro:IPR031325" /db_xref="SubtiList:BG10797" /db_xref="UniProtKB/Swiss-Prot:Q07833" /translation="MKKRKRRNFKRFIAAFLVLALMISLVPADVLAKSTEEENGNRIA ADDPEETLQKEQTEEAVPFDPKDINKEGEITSERTENTKLYYEGDGVYKQEVYLDPIH TKETPDADWEDISPELKESTSKQVETENAILNSDFQKQMKNGLYATFEHNDHKVTYSL AEAKGPNKTSLTPKDTSADYKTDSNEIVYPDVFPNIDLQTFTFNENIKEDLVLHQYNG YNTFTFQLKTDLQAKEQEDGSIDFSDEKGKVVFSVPKPFMTDSKLDELSGEVERSDKV SYKLEKNEEGYLLHLTADENWLKDPERVYPVSIDPSTSLSVSSDTFVMSAYPTTNYSA SSQKWDANLKAYVLKTGYYDKTTGTNYAFMKFNNLKPIQNMTVTKATLKTYVAHSYYG TKATGLWLDTVNSNYDNAKVTWNTKPASKNIGKADVHKGQWASYDVTAAVKSWNSGGA NYGFKLHTNGNGKEYWKKLISSANSANKPYIEVTYTIPKGNTPTIKAYHNGDSTGYFD ISWKKVEGAKGYKVWIYNGKEYQAISAGNVTSWSTKGKKIWPTSAEIASKRYKLHLDG KDGAELALDPSPVYKNSGGSYATSKNYWIGVSAIFDQGEGAMSAPAKPVIPNVGKAQA PSAKGYNNGNATGYFDLSWKAVSGATGYKVQVFNGKGFETLDLGNQTSWTTKGKKIWP TSAEIKAGKYALHLKDGSGAELPINPGPTYKNAGGDGAKRNYSFKIIAYNKDGEAIAS PAATPALPDIARPKNVTGYLYTNTKSSQTGYVNLIWEKVQNAKGYKVNIYNGKEYQSF DVGDADHWTTQNKNIWPTSEEIKAGSYKLHTDGKGGELALDPSPVYNNANGNYKGKKN YSFTLVAYDANGETIPTAPFNPTFHEGAEFLGTEEYWSIIDIPSGQLNGATGNVIVNE EDLSIDGRGPGLGLSRTYNSLDSSDHLFGQGWYADAETSVISTDGGAMYIDEDATTHR FTKKADGTYQPPTGVYLELTETADQFILKTKDQTNAYFNKKGGKLQKVVDGHNNATVY TYNDKNQLTAITDASGRKLTFTYDENGHVTSITGPKNKKVTYSYENDLLKKVTDTDGT VTSYDYDSEGRLVKQYSANSTEAKPVFTEYQYSGHRLEKAINAKKETYVYSYDADKKT LLMTQPNGRKVQYGYNEAGNPIQVIDDAEGLKITTNTKYEGNNVVEDVDPNDVGTGKA TESYQYDKDGNVTSVKDAYGTETYEYNKNNDVTKMKDTEGNVTDIAYDGLDAVSETDQ SGKSSSAAVYDKYGNQIQSSKDLSASTNILKDGSFEAQKSGWNLTASKDSGKISVIAD KSGVLSGSKALEVLSQSTSAGTDHGYSSATQTVELEPNTTYTLSGKIKTDLAKSRAYF NIDLRDKDQKRIQWIHNEYSALAGKNDWTKRQITFTTPANAGKAVVYMEVDHKDKDGK GKAWFDEVQLEKGEVSSSYNPVQNSSFTSATENWNVSGASVDSEEGFNDDVSLKAART SASQAGSVTKQTVVLGQSANDKPVYLTLTGMSKASSVKFTDEKDYSLQANVTYADGST GIYNAKFPSGTQEWNRAAVVIPKTKPINKVDISILFQKSATGTVWFDDIRLIEGSLLT KSTYDSNGNYVTKEEDELGYATSTDYDETGKKTSETDAKGEKTTYTYDQADQLTNMTL SNGTSILHSYDKEGNEVSKTIRAGADQTYKFEYDVMGKLVKTTDPLGNVLASEYDANS NLTKTISPNGNEVSLSYDGTDRVKSKSYNGTEKYIFTYDKNGNETSVVNKEQNTTKKR TFDNKNRLTELTDRGGSQTWTYPSDSDKLKTFSWIHGDQKGTNQFTYNKLDQMIEMKD STSSYSFDYDENGNVQTFITGNGGGTSFSYDERNLVSSLHIGDKNGGDILTESYEYDA NGNRTTINSSASGKVQYEYGKLNQLVKETHEDGTVIEYTYDGFGNRKTVTTIKDGSSK TVNASFNIMNQLTKVNDESISYDKNGNRTSDGKFTYTWDAEDNLTAVTKKGEDKPFAT YKYDEKGNRIQKTVNGKVTNYFYDGDSLNVLYETDADNNVTKSYTYGDSGQLLSYTEN GKKYFYHYNAHGDIIAISDSTGKTVAKYQYDAWGNPTKTEASDEVKDNRYRYAGYQYD EETGLYYLMARYYEPRNGVFLSLDPDPGSDGDSLDQNGYAYGNNNPVMNVDPDGHWVW LVVNAGFAAYDGYKAYKSGKGWKGAAWAAASNFGPGKIFKGASRAYKFTKKAVKITGH TRHGLNQSIGRNGGRGVNLRAKLNAVRSPKKVIKQPNGATKYVGKKATVVLNKRGKVI TAYGSSRAKGSKHVFHTHGKGNKSKRRR*" /label="wapA CDS" gene complement(3403910..3410914) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /label="wapA gene" misc_feature 3410921..3410935 /Source="Nicolas_upshift_promotors" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3410935 /Source="Nicolas_upshifts" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3410945..3410964) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3410960) /Source="Nicolas_upshifts" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3410979..3410986) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3411076..3412011) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391803.1" /db_xref="EnsemblGenomes-Gn:BSU39240" /db_xref="EnsemblGenomes-Tr:CAB15960" /db_xref="GOA:Q07835" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10796" /db_xref="UniProtKB/Swiss-Prot:Q07835" /translation="MQQDPSISSKQKSTAVIKMVISMVIFGSIGFFSEHTNLPSFELV FVRCLCATLFLGFCWLASGQYKTEKWSKRDVLQTLACGFFLVFNWVFLFKSFEETSVT IAISVYHLAPVLVLLLGSFFYREKLNVISVSSIIICFLGTALISGINGSTSLTQLMGS GIIWAVLAALFYAFTTLLGKGIHNLSPYTTTFLQTGLGVIILIPFIHFGAFADLSQGN WIMVVSTGIIHTGIVYLLFFDSLRFLSTKFISIIVFLDPAVAIVLDTVFTGFRPDLYQ TLGIVMIFAGMALTLVRRQGKANVTAEGTDIEQIQ*" /label="yxxF CDS" gene complement(3411076..3412011) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /label="yxxF gene" downshifts complement(3411297) /Source="Nicolas_upshifts" /id="D2038" /incds=1 /nref=1 /ntot=153 /MaxReadThrough="1.33481" /MaxDrop="2.42407" /score="29.0290332" /energy="-5.9" /TU="NA" /idTUdmin="U3098" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(3412012..3412132) /Source="Nicolas_S_feature" /locus_tag="new_4031646_4031766_c" /HighExp="T3.0H, T1.0H, T3.30H, LBGstat, T1.30H, T0.30H, T4.0H, M9-stat, T2.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="Sig-" /TUlongPSig="0.196" /label="S1512" CDS complement(3412163..3412609) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10913081, 12644671, 17210127" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 12644671, 17210127; Product type f: factor" /codon_start=1 /transl_table=11 /product="phosphate starvation protein (universal stress protein A family)" /protein_id="NP_391804.1" /db_xref="EnsemblGenomes-Gn:BSU39250" /db_xref="EnsemblGenomes-Tr:CAB15961" /db_xref="GOA:P42297" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11134" /db_xref="UniProtKB/Swiss-Prot:P42297" /translation="MFNKMLVAIDGSDMSAKALDAAVHLAKEQQAELSILHVGREAVV TTSSLTGIVYVPEHFIDEIRNEVKKEGLKILENAKEKAAEKGVQAETIYANGEPAHEI LNHAKEKGVSLIVVGSRGISGLKEMMLGSVSHKVSQLSTCPVLIVR*" /label="yxiE CDS" gene complement(3412163..3412609) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /label="yxiE gene" downshifts complement(3412177) /Source="Nicolas_upshifts" /id="D2039" /incds=0 /nref=22 /ntot=144 /MaxReadThrough="4.33955" /MaxDrop="6.75522" /score="45.6082379" /energy="-8.4" /TU="U3098" /idTUdmin="U3099" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3412646..3412665) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3412653) /Source="Nicolas_upshifts" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3412679..3412686) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3412712..3414121) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_391805.2" /db_xref="EnsemblGenomes-Gn:BSU39260" /db_xref="EnsemblGenomes-Tr:CAB15962" /db_xref="GOA:P40740" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG10935" /db_xref="UniProtKB/Swiss-Prot:P40740" /translation="MSSNEKRFPEGFLWGGAVAANQVEGAYNEGGKGLSTADVSPNGI MSPFDESMTSLNLYHNGIDFYHRYKEDIALFAEMGFKAFRTSIAWTRIFPNGDEEEPN EEGLRFYDDLFDELLKHHIEPVVTISHYEMPLGLVKNYGGWKNRKVIEFYERYAKTVF KRYQHKVKYWMTFNEINVVLHAPFTGGGLVFEEGENKLNAMYQAAHHQFVASALAVKA GHDIIPDSKIGCMIAATTTYPMTSKPEDVFAAMENERKTLFFSDVQARGAYPGYMKRY LAENNIEIEMAEGDEELLKEHTVDYIGFSYYMSMAASTDPEELAKSGGNLLGGVKNPY LKSSEWGWQIDPKGLRITLNTLYDRYQKPLFIVENGLGAVDKVEEDGTIQDDYRINYL RDHLIEAREAIADGVELIGYTSWGPIDLVSASTAEMKKRYGFIYVDRDNEGNGTFNRI KKKSFNWYQQVIATNGESL*" /label="bglH CDS" gene complement(3412712..3414121) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /label="bglH gene" CDS complement(3414144..3415973) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /EC_number="2.7.1.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17074746, 8626332" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17074746, 8626332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) beta-glucoside-specific enzyme IIBCA component" /protein_id="NP_391806.2" /db_xref="EnsemblGenomes-Gn:BSU39270" /db_xref="EnsemblGenomes-Tr:CAB15963" /db_xref="GOA:P40739" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011297" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10934" /db_xref="UniProtKB/Swiss-Prot:P40739" /translation="MDYDKLSKDILQLVGGEENVQRVIHCMTRLRFNLHDNAKADRSQ LEQLPGVMGTNISGEQFQIIIGNDVPKVYQAIVRHSNLSDEKSAGSSSQKKNVLSAVF DVISGVFTPILPAIAGAGMIKGLVALAVTFGWMAEKSQVHVILTAVGDGAFYFLPLLL AMSAARKFGSNPYVAAAIAAAILHPDLTALLGAGKPISFIGLPVTAATYSSTVIPILL SIWIASYVEKWIDRFTHASLKLIVVPTFTLLIVVPLTLITVGPLGAILGEYLSSGVNY LFDHAGLVAMILLAGTFSLIIMTGMHYAFVPIMINNIAQNGHDYLLPAMFLANMGQAG ASFAVFLRSRNKKFKSLALTTSITALMGITEPAMYGVNMRLKKPFAAALIGGAAGGAF YGMTGVASYIVGGNAGLPSIPVFIGPTFIYAMIGLVIAFAAGTAAAYLLGFEDVPSDG SQQPAVHEGSREIIHSPIKGEVKALSEVKDGVFSAGVMGKGFAIEPEEGEVVSPVRGS VTTIFKTKHAIGITSDQGAEILIHIGLDTVKLEGQWFTAHIKEGDKVAPGDPLVSFDL EQIKAAGYDVITPVIVTNTDQYSFSPVKEIGKVQPKEALLALS*" /label="bglP CDS" gene complement(3414144..3415973) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /label="bglP gene" promotor_no_box complement(3415965..3416065) /Source="Nicolas_upshift_promotors" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="promotor_no_box" upshifts complement(3416005) /Source="Nicolas_upshifts" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="upshifts" S_feature complement(3416007..3416199) /Source="Nicolas_S_feature" /locus_tag="new_4035641_4035833_c" /HighExp="Diami, T0.30H, B60, T0.0H, G150, M9-stat, T1.0H, T1.30H, Gly, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29980099999999998" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.998, 0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1513" promotor_-10 complement(3416180..3416199) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3416199) /Source="Nicolas_upshifts" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3416201..3416334) /Source="Nicolas_S_feature" /locus_tag="new_4035835_4035968_c" /HighExp="S2, HiTm, Sw, S8, M9-stat, Lbstat, S0, T2.0H, Mal, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1514" promotor_-35 complement(3416212..3416219) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3416356..3416664) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391807.1" /db_xref="EnsemblGenomes-Gn:BSU39280" /db_xref="EnsemblGenomes-Tr:CAB15964" /db_xref="SubtiList:BG11071" /db_xref="UniProtKB/Swiss-Prot:P40738" /translation="MLLINKQKDPVFQFLAGTFHQDIETPDDAIQELLIEESKEYLED AIVFLTDFIESEHSDNKKNDYIQSCADGVYLPAFNLEPIDWLKNVIVQIKKSLKKFKR *" /label="yxxE CDS" gene complement(3416356..3416664) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /label="yxxE gene" downshifts complement(3416379) /Source="Nicolas_upshifts" /id="D2040" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.99098" /MaxDrop="5.76651" /score="24.0715465" /energy="-21.3" /TU="U3101,U3102" /idTUdmin="U3101" /TUdmin="-3718" /isTUend="FALSE" /label="downshifts" CDS complement(3416710..3417153) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin factor of the RttD-RttE toxin-antitoxin system" /protein_id="NP_391808.1" /db_xref="EnsemblGenomes-Gn:BSU39290" /db_xref="EnsemblGenomes-Tr:CAB15965" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG11070" /db_xref="UniProtKB/Swiss-Prot:P40737" /translation="MSYNFIKSNKENDFYPVNQSEIEEVEKNLNLKLPSELVNFYLEV GYGFIKGSEFNTNRILDPYSVRDFRLRINDFEFYPDIEIYDEFENDKLIFFEGSESAL MSIELNDNNKNPIYYYDIQIATSLTEFLRKIEENDQYYLDLLDDE*" /label="rtbE CDS" gene complement(3416710..3417153) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /label="rtbE gene" CDS complement(3417150..3418859) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease toxin of the RtbD-RtbE toxin-antitoxin system" /protein_id="NP_391809.2" /db_xref="EnsemblGenomes-Gn:BSU39300" /db_xref="EnsemblGenomes-Tr:CAB15966" /db_xref="GOA:P42296" /db_xref="InterPro:IPR003615" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG11133" /db_xref="UniProtKB/Swiss-Prot:P42296" /translation="MKTLDVHALHEGIQHTIEKLDKQKQQLEKLEKSVEHLAGMKDAL KGKGGDAIRTFYEECHKPFLLFFGIFIDEYKKVLKQTQHAISSVESNSHGMIAEAFLS HDARHGVKHAREVTEQLTDAVNRQTSAIDHIVSLPTVNDSFFRMETEQAERLISDTLN KLFQFDGQQTQALEAAKSDFQTMKKYIDQLETMYTGPKIEITGYKSGSILKSQEEENI NQIFGAINPQMKQADDSPMEMMLKKLAENEKSKVDSVVKTGDSKKVSKNIIVINGKVY NTSEHREHIKTDFSNAEVKQVVYNDTLYNVYISGNDMKLEPVVSLSDIKVDENGYVKI LETAVELTGVYDLFKAATGRDPVSGEKVTGKDRVVASINSVPFAKIAKLEKLIDINKL INNGKKAKKASEVKNVAKDKGKIANDVSGSANKINSDLIKKYARDIEQRTGRELPKNQ IDKLKEALRNKEYKKMSPIETAKHRTKFDKVKNKVIKEWEENTGQKWPVYKENVVSEK TGKIIRKKGDKYDAHHIIENTFGGEHEWWNMHPAKFPNEHQAGIHGTGSPANELFKGG KKK*" /label="rtbD CDS" gene complement(3417150..3418859) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /label="rtbD gene" misc_feature complement(3418021..3418040) /Source="Nicolas_upshift_promotors" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3418029) /Source="Nicolas_upshifts" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="upshifts" CDS complement(3418879..3419148) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391810.1" /db_xref="EnsemblGenomes-Gn:BSU39310" /db_xref="EnsemblGenomes-Tr:CAB15967" /db_xref="InterPro:IPR020315" /db_xref="SubtiList:BG11132" /db_xref="UniProtKB/Swiss-Prot:P42295" /translation="MAQEIKMVYDTVKQGLSQLKNSAELKSSLPGHLSGRNHLNVVKS IEQLNKDIKELTEAYASVLAKHIAQTESAVNAMKETDENISSSMK*" /label="yxiC CDS" gene complement(3418879..3419148) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /label="yxiC gene" CDS complement(3419160..3419525) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391811.1" /db_xref="EnsemblGenomes-Gn:BSU39320" /db_xref="EnsemblGenomes-Tr:CAB15968" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG11131" /db_xref="UniProtKB/Swiss-Prot:P42294" /translation="MHSEMLLHSVKADLHEKQEQIHQLKRVLHEIRQIKHDFSEAQHL IHRPHLNREAWRGTHAERFEDIREGMNKAYQQIKSDQVSGIIESIEGKIHSLEGDVYS IRRQITRIEHEIEKEKHKK*" /label="yxiB CDS" gene complement(3419160..3419525) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /label="yxiB gene" S_feature complement(3419526..3419591) /Source="Nicolas_S_feature" /locus_tag="new_4039160_4039225_c" /HighExp="T-1.40H, T-3.40H, T2.30H, T-2.40H, T-0.40H, T1.0H, T-1.10H, T-5.40H, T3.30H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1515" promotor_-10 complement(3419578..3419597) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3419591) /Source="Nicolas_upshifts" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3419612..3419615) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3419832..3421241) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 18408032, 18607095, 20883454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 18408032, 18607095, 20883454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan endo-1,5-alpha-L-arabinosidase ([Ca(2+)-dependent]" /protein_id="NP_391812.2" /db_xref="EnsemblGenomes-Gn:BSU39330" /db_xref="EnsemblGenomes-Tr:CAB15969" /db_xref="GOA:P42293" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR023296" /db_xref="InterPro:IPR032291" /db_xref="PDB:2X8F" /db_xref="PDB:2X8S" /db_xref="PDB:2X8T" /db_xref="PDB:4COT" /db_xref="SubtiList:BG11130" /db_xref="UniProtKB/Swiss-Prot:P42293" /translation="MFNRLFRVCFLAALIMAFTLPNSVYAQKPIFKEVSVHDPSIIET NGTFYVFGSHLASAKSNDLMQWQQLTTSVSNDNPLIPNVYEELKETFEWAQSDTLWAA DVTQLADGKYYMYYNACRGDSPRSAMGVAVADNIEGPYKNKGIFLKSGMEGTSSDGTP YDATKHPNVVDPHTFFDKDGKLWMVYGSYSGGIFILEMNPKTGFPLPGQGYGKKLLGG NHSRIEGPYVLYNPDTQYYYLYLSYGGLDATGGYNIRVARSKKPDGPYYDAEGNPMLD VRGKGGTFFDDRSIEPYGVKLMGSYTFETENEKGTGYVSPGHNSAYYDEKTGRSYLIF HTRFPGRGEEHEVRVHQLFMNKDGWPVAAPYRYAGETLKEVKQKDITGTYKLIQHGKD ISADIKQTINIQLNKNHTISGEMTGTWRKTGKNTADITLAGKKYNGVFLRQWDSVREK NVMTFSVLNTSGEAVWGSK*" /label="abnB CDS" gene complement(3419832..3421241) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /label="abnB gene" downshifts complement(3419855) /Source="Nicolas_upshifts" /id="D2041" /incds=0 /nref=2 /ntot=38 /MaxReadThrough="0.825980000000001" /MaxDrop="3.49689" /score="16.962389" /energy="-7.9" /TU="NA" /idTUdmin="U3101" /TUdmin="-7194" /isTUend="FALSE" /label="downshifts" S_feature complement(3421242..3421351) /Source="Nicolas_S_feature" /locus_tag="new_4040876_4040985_c" /HighExp="S2, T2.30H, BC, T2.0H, M9-stat, T3.0H, T3.30H, T4.0H, S1, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1516" CDS complement(3421375..3421539) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097797.1" /db_xref="EnsemblGenomes-Gn:BSU39339" /db_xref="EnsemblGenomes-Tr:CAX52712" /db_xref="UniProtKB/Swiss-Prot:C0H3T6" /translation="MAVSQLMQNLTKQLLHVRERKTDVMQEGETAKELNYEGEDMQAT SSAQNRQTSV*" /label="yxzL CDS" gene complement(3421375..3421539) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /label="yxzL gene" promotor_-10 complement(3421424..3421442) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3421439) /Source="Nicolas_upshifts" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3421453..3421461) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3421731..3421750) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3421747) /Source="Nicolas_upshifts" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3421763..3421770) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3421779..3421786 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3421801..3421820 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3421804 /Source="Nicolas_upshifts" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="upshifts" CDS 3421858..3422304 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391813.2" /db_xref="EnsemblGenomes-Gn:BSU39340" /db_xref="EnsemblGenomes-Tr:CAB15970" /db_xref="GOA:P10943" /db_xref="InterPro:IPR015111" /db_xref="InterPro:IPR023552" /db_xref="InterPro:IPR036482" /db_xref="PDB:1VEA" /db_xref="PDB:1WMQ" /db_xref="PDB:1WPS" /db_xref="PDB:1WPT" /db_xref="PDB:1WPU" /db_xref="PDB:1WPV" /db_xref="PDB:1WRN" /db_xref="PDB:1WRO" /db_xref="PDB:1WRQ" /db_xref="PDB:3BOY" /db_xref="PDB:4H4L" /db_xref="SubtiList:BG10666" /db_xref="UniProtKB/Swiss-Prot:P10943" /translation="MTLHKERRIGRLSVLLLLNEAEESTQVEELERDGWKVCLGKVGS MDAHKVVAAIETASKKSGVIQSEGYRESHALYHATMEALHGVTRGEMLLGSLLRTVGL RFAVLRGNPYESEAEGDWIAVSLYGTIGAPIKGLEHETFGVGINHI*" /label="hutP CDS" gene 3421858..3422304 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /label="hutP gene" downshifts 3422309 /Source="Nicolas_upshifts" /id="D2042" /incds=0 /nref=157 /ntot=226 /MaxReadThrough="6.10706" /MaxDrop="5.43744" /score="3.19376411" /energy="-17.8" /TU="U3105" /idTUdmin="U3105" /TUdmin="-7018" /isTUend="FALSE" /label="downshifts" CDS 3422417..3423943 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /EC_number="4.3.1.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9535092, 10220322, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine ammonia-lyase (histidase)" /protein_id="NP_391814.1" /db_xref="EnsemblGenomes-Gn:BSU39350" /db_xref="EnsemblGenomes-Tr:CAB15971" /db_xref="GOA:P10944" /db_xref="InterPro:IPR001106" /db_xref="InterPro:IPR005921" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR022313" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10667" /db_xref="UniProtKB/Swiss-Prot:P10944" /translation="MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERI VRDEKTIYGINTGFGKFSDVLIQKEDSAALQLNLILSHACGVGDPFPECVSRAMLLLR ANALLKGFSGVRAELIEQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGE VFFEGERMPAMTGLKKAGIQPVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTE RIASLTIEGLQGIIDAFDEDIHLARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDA YSLRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFNDGDKVISGGNFHGQPIAFA MDFLKIAISELANIAERRIERLVNPQLNDLPPFLSPHPGLQSGAMIMQYAAASLVSEN KTLAHPASVDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAVEYRG IEHAASYTKQLFQEMRKVVPSIQQDRVFSYDIERLTDWLKKESLIPDHQNKELRGMNI *" /label="hutH CDS" gene 3422417..3423943 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /label="hutH gene" CDS 3423940..3425598 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /EC_number="4.2.1.49" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15313616, 17395359, 22933560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urocanase" /protein_id="NP_391815.1" /db_xref="EnsemblGenomes-Gn:BSU39360" /db_xref="EnsemblGenomes-Tr:CAB15972" /db_xref="GOA:P25503" /db_xref="InterPro:IPR023636" /db_xref="InterPro:IPR023637" /db_xref="InterPro:IPR035085" /db_xref="InterPro:IPR035400" /db_xref="InterPro:IPR035401" /db_xref="InterPro:IPR036190" /db_xref="PDB:2FKN" /db_xref="SubtiList:BG10668" /db_xref="UniProtKB/Swiss-Prot:P25503" /translation="MTDVKKSIRANRGTELECLGWEQEAVLRMLRNNLDPEVAEKPED LIVYGGIGKAARDWDAFHAIEHSLKTLKNDETLLVQSGKPVGMFRTHPQAPRVLLANS VLVPKWADWEHFHELEKKGLMMYGQMTAGSWIYIGSQGILQGTYETFAELARQHFGGS LKGTLTLTAGLGGMGGAQPLSVTMNEGVVIAVEVDEKRIDKRIETKYCDRKTASIEEA LAWAEEAKLAGKPLSIALLGNAAEVHHTLLNRGVKIDIVTDQTSAHDPLIGYVPEGYS LDEADRLRQDTPELYVRLAKQSMKKHVEAMLAFQQKGSIVFDYGNNIRQVAKDEGLEN AFDFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIYRTDALLKELFPTNKALHRWIDM AQEKVTFQGLPSRICWLGYGERKKMGLAINELVRTGELKAPVVIGRDHLDCGSVASPN RETEAMKDGSDAVGDWAVLNALVNTAAGASWVSFHHGGGVGMGYSLHAGMVAVADGSE LADERLARVLTSDPGMGIIRHADAGYERAVEVAKEQDIIVPMQK*" /label="hutU CDS" gene 3423940..3425598 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /label="hutU gene" CDS 3425611..3426876 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /EC_number="3.5.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16990261, 17395359, 18296777" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16990261, 17395359, 18296777; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazolone-5-propionate hydrolase" /protein_id="NP_391816.1" /db_xref="EnsemblGenomes-Gn:BSU39370" /db_xref="EnsemblGenomes-Tr:CAB15973" /db_xref="GOA:P42084" /db_xref="InterPro:IPR005920" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2BB0" /db_xref="PDB:2G3F" /db_xref="SubtiList:BG11100" /db_xref="UniProtKB/Swiss-Prot:P42084" /translation="MPKQIDTILINIGQLLTMESSGPRAGKSMQDLHVIEDAVVGIHE QKIVFAGQKGAEAGYEADEIIDCSGRLVTPGLVDPHTHLVFGGSREKEMNLKLQGISY LDILAQGGGILSTVKDTRAASEEELLQKAHFHLQRMLSYGTTTAEVKSGYGLEKETEL KQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFLDQMLSLLPEIKEQELASFA DIFTETGVFTVSQSRRYLQKAAEAGFGLKIHADEIDPLGGAELAGKLKAVSADHLVGT SDEGIKKLAEAGTIAVLLPGTTFYLGKSTYARARAMIDEGVCVSLATDFNPGSSPTEN IQLIMSIAALHLKMTAEEIWHAVTVNAAYAIGKGEEAGQLKAGRSADLVIWQAPNYMY IPYHYGVNHVHQVMKNGTIVVNREGAILG*" /label="hutI CDS" gene 3425611..3426876 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /label="hutI gene" CDS 3426869..3427828 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /EC_number="3.5.3.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931887, 15355972, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formiminoglutamate hydrolase" /protein_id="NP_391817.1" /db_xref="EnsemblGenomes-Gn:BSU39380" /db_xref="EnsemblGenomes-Tr:CAB15974" /db_xref="GOA:P42068" /db_xref="InterPro:IPR005923" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="PDB:3M1R" /db_xref="SubtiList:BG11099" /db_xref="UniProtKB/Swiss-Prot:P42068" /translation="MDKYPFLREAGSSFKDRDVTKMSDLIATWDGQDIKGPALIGVPL SKSSISHSGASFAPGTIRQALKHSSAYSAELGEHVVSELLYDLGDIDIHVTDIVKSHH HIFQTMHALLSDHPDWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTED GGPTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKG LIPTIKEILPVVQDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQ QPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK*" /label="hutG CDS" gene 3426869..3427828 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /label="hutG gene" S_feature 3427829..3427903 /Source="Nicolas_S_feature" /locus_tag="new_4047463_4047537" /HighExp="Sw, BC, T3.30H, T4.0H, T5.0H, T3.0H, T2.30H, S8, M9-stat, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1517" CDS 3427904..3429331 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="histidine degradation metabolites permease" /protein_id="NP_391818.2" /db_xref="EnsemblGenomes-Gn:BSU39390" /db_xref="EnsemblGenomes-Tr:CAB15975" /db_xref="GOA:P42087" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11101" /db_xref="UniProtKB/Swiss-Prot:P42087" /translation="MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQA GPGGTILAYVIGGLMMYLVMQCLGELSVAMPVTGSFQKYATTFIGPSTGFMVGIMYWI NWVVTVGSEFTASGILMQRWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSV KIVTIILFIILGGAAMFGLISLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFA FSGTELIGVTAGESANPQKDIPRSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESP FVAVFAEIGIPYAADIMNFVILTALLSVANSGLYASTRMMWSLANENMISSRFKKVTS KGIPLNALMISMAVSCLSLVSSIVAPGTVYVVMVAIAGFAGVVVWMSIALSQLLFRKR FLKKGGDVKDLTFRTPLYPLMPIAALLLCSASCIGLAFDPNQRIALFCGVPCIILCYL IYHFKRNVTKAKKISQEEYPADHIL*" /label="hutM CDS" gene 3427904..3429331 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /label="hutM gene" downshifts 3429327 /Source="Nicolas_upshifts" /id="D2043" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="0.7432" /MaxDrop="6.18816" /score="8.21347356" /energy="-11.7" /TU="NA" /idTUdmin="U3105" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3429375..3430676) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /EC_number="2.4.2.2" /EC_number="2.4.2.3" /EC_number="2.4.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 15530033, 16469506, 21707079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 15530033, 16469506, 21707079; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside phosphorylase" /protein_id="NP_391819.2" /db_xref="EnsemblGenomes-Gn:BSU39400" /db_xref="EnsemblGenomes-Tr:CAB15976" /db_xref="GOA:P39142" /db_xref="InterPro:IPR000053" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR013102" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR017872" /db_xref="InterPro:IPR018090" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="InterPro:IPR036566" /db_xref="PDB:5EP8" /db_xref="SubtiList:BG10985" /db_xref="UniProtKB/Swiss-Prot:P39142" /translation="MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMA IFFQDMSDRERADLTMAMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAAL DVPVAKMSGRGLGHTGGTIDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPA DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELA KAMVRIGNNVGRQTMAVISDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLG SQMVVLAKKADTLDEARAKLEEVMKNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAY QIDVPAKEAGVVSEIVADEIGVAAMLLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGE PLVTLYANRENVDEVIAKVYDNIRIAAEAKAPKLIHTLITE*" /label="pdp CDS" gene complement(3429375..3430676) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /label="pdp gene" downshifts complement(3429392) /Source="Nicolas_upshifts" /id="D2044" /incds=0 /nref=122 /ntot=224 /MaxReadThrough="1.27022" /MaxDrop="5.60021" /score="14.0361257" /energy="-13.1" /TU="NA" /idTUdmin="U3107" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(3430706..3431887) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8550462, 11065368, 12591866, 15849754, 16850406, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 11065368, 12591866, 15849754, 16850406, 25890046; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside Na+(H+) cotransporter" /protein_id="NP_391820.2" /db_xref="EnsemblGenomes-Gn:BSU39410" /db_xref="EnsemblGenomes-Tr:CAB15977" /db_xref="GOA:P39141" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG10984" /db_xref="UniProtKB/Swiss-Prot:P39141" /translation="MKYLIGIIGLIVFLGLAWIASSGKKRIKIRPIVVMLILQFILGY ILLNTGIGNFLVGGFAKGFGYLLEYAAEGINFVFGGLVNADQTTFFMNVLLPIVFISA LIGILQKWKVLPFIIRYIGLALSKVNGMGRLESYNAVASAILGQSEVFISLKKELGLL NQQRLYTLCASAMSTVSMSIVGAYMTMLKPEYVVTALVLNLFGGFIIASIINPYEVAK EEDMLRVEEEEKQSFFEVLGEYILDGFKVAVVVAAMLIGFVAIIALINGIFNAVFGIS FQGILGYVFAPFAFLVGIPWNEAVNAGSIMATKMVSNEFVAMTSLTQNGFHFSGRTTA IVSVFLVSFANFSSIGIIAGAVKGLNEKQGNVVARFGLKLLYGATLVSFLSAAIVGLI Y*" /label="nupC CDS" gene complement(3430706..3431887) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /label="nupC gene" S_feature complement(3431888..3431967) /Source="Nicolas_S_feature" /locus_tag="new_4051522_4051601_c" /HighExp="G150, G135, Oxctl, G180, Mt0, M40t45, Lbtran, M0t90, M40t90, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1518" CDS complement(3431968..3432639) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /EC_number="4.1.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 27033207" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 27033207; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyribose-phosphate aldolase" /protein_id="NP_391821.2" /db_xref="EnsemblGenomes-Gn:BSU39420" /db_xref="EnsemblGenomes-Tr:CAB15978" /db_xref="GOA:P39121" /db_xref="InterPro:IPR002915" /db_xref="InterPro:IPR011343" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR028581" /db_xref="SubtiList:BG10983" /db_xref="UniProtKB/Swiss-Prot:P39121" /translation="MSLANIIDHTALKPHTQKADILKLIEEAKTYKFASVCVNPTWVE LAAKELKGTGVDVCTVIGFPLGANTTETKAFETKDAISKGATEVDMVINIAALKDKED DVVEADIRGVVEAVAGKALVKVIIETCLLTDEEKERACRLAVSAGADFVKTSTGFSTG GATKEDIALMRKTVGPDIGVKASGGVRTKEDVDTMVEAGASRIGASAGVSIVKGENAS GGDNY*" /label="deoC CDS" gene complement(3431968..3432639) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /label="deoC gene" promotor_-35 3432588..3432591 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3432606 /Source="Nicolas_upshifts" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3432607..3432626 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3432667..3432686) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3432682) /Source="Nicolas_upshifts" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3432700..3432707) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3432745..3433686) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 10714997, 24863636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 10714997, 24863636; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of pyrmidine deoxyribonucleosides degradation (DeoR-dR5P)" /protein_id="NP_391822.1" /db_xref="EnsemblGenomes-Gn:BSU39430" /db_xref="EnsemblGenomes-Tr:CAB15979" /db_xref="GOA:P39140" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR013324" /db_xref="PDB:4OQP" /db_xref="PDB:4OQQ" /db_xref="SubtiList:BG10982" /db_xref="UniProtKB/Swiss-Prot:P39140" /translation="MDREKQQLSIEAARLYYQSDYSQQQIAEQLNISRPTVSRLLQYA KEKGYVQIRVMDPFEDLDALGSILEEKYGLLEAHVVFSPTPDYAGITHDLSRYGAEYM HETVKDGDIVGVSWGTTMYQIAQNMQPKQVKGVEVVQLKGGISHSRVNTYSAETIQLF AEAFQTMPRYLPLPVVFDNADVKRMVEKDRHIERIIEMGKQANIALFTVGTVRDEALL FRLGYFNEEEKALLKKQAVGDICSRFFDAKGNICSSAINDRTIGVELQDLRLKERSIL VAGGSRKVSSIHGALTGKYANVLIIDQHTARALVNDL*" /label="deoR CDS" gene complement(3432745..3433686) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /label="deoR gene" promotor_-10 complement(3433731..3433750) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3433737) /Source="Nicolas_upshifts" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3433739..3433819) /Source="Nicolas_S_feature" /locus_tag="new_4053373_4053453_c" /HighExp="Etha, Diami, Salt, MG 10, Gly, MG 60, G180, GM 60, G135, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.55204399999999998" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1519" promotor_-35 complement(3433766..3433769) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3433820..3434647) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391823.2" /db_xref="EnsemblGenomes-Gn:BSU39440" /db_xref="EnsemblGenomes-Tr:CAB15980" /db_xref="GOA:P39139" /db_xref="InterPro:IPR009597" /db_xref="SubtiList:BG10981" /db_xref="UniProtKB/Swiss-Prot:P39139" /translation="MAVKDRYMSKIKQETKPWIKRFGRLGYFAFGGVFILLGVLAFMT AAGAGRAKDSSGALQTLSRMPYGSLLLFFIGIGLIGYVIWMVLSAIKDTEGHGNSRRG LSRRIGNFFSAAVYTSIAWNALRFVFGQGDGGTSEQTWSAYVLAQPFGQWLTGLTGAG FIVFAIVQFMKGVRAAFMKEFDTSKMNKQMICITKNTGRAGNIARAIIFSAIGYFLIK TAMTADPDDTRGFDGALAELAQQPHGKLILSILALGLILYGMYAIMKGIYQHMTWEK* " /label="yxxB CDS" gene complement(3433820..3434647) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /label="yxxB gene" downshifts complement(3434619) /Source="Nicolas_upshifts" /id="D2045" /incds=0 /nref=6 /ntot=96 /MaxReadThrough="4.46865" /MaxDrop="3.48502" /score="14.6805498" /energy="-16" /TU="U3109,U3111" /idTUdmin="U3111" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3434672..3434690) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3434685) /Source="Nicolas_upshifts" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3434704..3434710) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3434720..3435832) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1860825, 10746760, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ethanolamine permease" /protein_id="NP_391824.1" /db_xref="EnsemblGenomes-Gn:BSU39450" /db_xref="EnsemblGenomes-Tr:CAB15981" /db_xref="GOA:P54957" /db_xref="InterPro:IPR007441" /db_xref="SubtiList:BG11894" /db_xref="UniProtKB/Swiss-Prot:P54957" /translation="MTVNDAVVFILAAFLLWGAADYCLGNRWGLGERFADGFKAMGPL ALSMIGIVSLAPVLAAILIPIVAPFYTAIGADPSSFANTILAIDMGGYALAGEMAKDP QAGLFSWVFLGTMMGPAIVFTIPVALGIIEKEDHPYFAKGILIGLCTVPIGCLIGGLC AGFDIGMIGKNLLIPSLLSAVIAFGLWRYTDRMIQLFHLFGKAVSMVAIIGLAAVSVE TMTGIVLIPGMENVETGIQTTGTIAIALAGAFPMTAFITKTFKKPLQALGKCLHLDET ATAGLVTSLAHHIPMLASLKDMTPRGKVINVAFAVSGAFVLGSHLGFVAGMKKEMAAA MIIGKLAGGVTAAAAAAWMTPAQSAKQQKRISASHS*" /label="yxeR CDS" gene complement(3434720..3435832) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /label="yxeR gene" CDS complement(3435902..3437239) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic enzyme" /protein_id="NP_391825.2" /db_xref="EnsemblGenomes-Gn:BSU39460" /db_xref="EnsemblGenomes-Tr:CAB15982" /db_xref="GOA:P54956" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11893" /db_xref="UniProtKB/Swiss-Prot:P54956" /translation="MSKQGLTAGLAEAVRTSQPEHSVDAIHEAKKGLLDFTAASFAGR EDKGIQKLLRLIEDEGGRPLVPVIGQGKKAAPLQSAMLNGFIAHALDFDDVHSDVRGH PSAVIVPALIASAARGHDERLLGAYVVGVEVMARLGESIGSRHYEKGWHNTGTLGAIA AACAVGYAEELTQEELEKAIGFAATQSAGMRVQFGTEMKPLHAGLAAQAGLLAVKLAQ SEFGGSRTALDGETGFFSLYGDVEKAQHTLLNDWGAPWRIVQPGLWFKIYPFCSAAHH AADAVRQLISEETISAANTERIEVIFPPGGDAALTERSPKAGEEGRFSVEYVIALALH GHGLTVEHFSSQPIPNGVQTTMGRIQRVYDNAIQPAPHAVPKGRFTIVRAYLSDGRIC EARVDCPKGAPGNELSEEDIIEKLTLTVPQEKARRIITAVEKADIKEFLAHIE*" /label="yxeQ CDS" gene complement(3435902..3437239) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /label="yxeQ gene" CDS complement(3437236..3438378) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-sulfur-metabolite deacetylase" /protein_id="NP_391826.2" /db_xref="EnsemblGenomes-Gn:BSU39470" /db_xref="EnsemblGenomes-Tr:CAB15983" /db_xref="GOA:P54955" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="PDB:1YSJ" /db_xref="SubtiList:BG11892" /db_xref="UniProtKB/Swiss-Prot:P54955" /translation="MADKAFHTRLINMRRDLHEHPELSFQEVETTKKIRRWLEEEQIE ILDVPQLKTGVIAEIKGREDGPVIAIRADIDALPIQEQTNLPFASKVDGTMHACGHDF HTASIIGTAMLLNQRRAELKGTVRFIFQPAEEIAAGARKVLEAGVLNGVSAIFGMHNK PDLPVGTIGVKEGPLMASVDRFEIVIKGKGGHAGIPNNSIDPIAAAGQIISGLQSVVS RNISSLQNAVVSITRVQAGTSWNVIPDQAEMEGTVRTFQKEARQAVPEHMRRVAEGIA AGYGAQAEFKWFPYLPSVQNDGTFLNAASEAAARLGYQTVHAEQSPGGEDFALYQEKI PGFFVWMGTNGTEEWHHPAFTLDEEALTVASQYFAELAVIVLETIK*" /label="sndB CDS" gene complement(3437236..3438378) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /label="sndB gene" CDS complement(3438395..3439144) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391827.1" /db_xref="EnsemblGenomes-Gn:BSU39480" /db_xref="EnsemblGenomes-Tr:CAB15984" /db_xref="GOA:P54954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11891" /db_xref="UniProtKB/Swiss-Prot:P54954" /translation="MITVKNIRKAFKDLVVLDGIDLEVKRGEVVAIIGPSGSGKSTLL RCLNLLERPDQGLIEIGEAKLNAEKFTRKEAHRLRQQTAMVFQNYNLFKNKTALQNIT EALIVAQHKPRDEAKRIGMEILKQVGLEHKADSYPITMSGGQQQRIGIARALAVNPHA ILLDEPTSALDPELVTGVLQVIKSIAEKQTTMIIVTHEMAFAKEVADQVIFMADGHII EQGTPEELFDHPKNERTKRFIKQVGEPAELI*" /label="yxeO CDS" gene complement(3438395..3439144) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /label="yxeO gene" CDS complement(3439157..3439831) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 15849754, 16513748, 16850406, 16885442; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391828.1" /db_xref="EnsemblGenomes-Gn:BSU39490" /db_xref="EnsemblGenomes-Tr:CAB15985" /db_xref="GOA:P54953" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11890" /db_xref="UniProtKB/Swiss-Prot:P54953" /translation="MNTIDWEFMISAFPTLIQALPITLFMAIAAMIFAIIGGLILALI TKNKIPVLHQLSKLYISFFRGVPTLVQLFLIYYGLPQLFPEMSKMTALTAAIIGLSLK NAAYLAEIFRAALNSVDDGQLEACLSVGMTKFQAYRRIILPQAIRNAIPATGNTFIGL LKETSLAFTLGVMEMFAQGKMYASGNLKYFETYLAVAIVYWVLTIIYSILQDLFERAM SKPYRT*" /label="yxeN CDS" gene complement(3439157..3439831) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /label="yxeN gene" CDS complement(3439854..3440648) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_391829.1" /db_xref="EnsemblGenomes-Gn:BSU39500" /db_xref="EnsemblGenomes-Tr:CAB15986" /db_xref="GOA:P54952" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11889" /db_xref="UniProtKB/Swiss-Prot:P54952" /translation="MKMKKWTVLVVAALLAVLSACGNGNSSSKEDDNVLHVGATGQSY PFAYKENGKLTGFDVEVMEAVAKKIDMKLDWKLLEFSGLMGELQTGKLDTISNQVAVT DERKETYNFTKPYAYAGTQIVVKKDNTDIKSVDDLKGKTVAAVLGSNHAKNLESKDPD KKINIKTYETQEGTLKDVAYGRVDAYVNSRTVLIAQIKKTGLPLKLAGDPIVYEQVAF PFAKDDAHDKLRKKVNKALDELRKDGTLKKLSEKYFNEDITVEQKH*" /label="yxeM CDS" gene complement(3439854..3440648) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /label="yxeM gene" promotor_-35 3440220..3440229 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3440241 /Source="Nicolas_upshifts" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3440242..3440257 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3440673..3441170) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur-containing aminoacid acetyltransferase" /protein_id="NP_391830.2" /db_xref="EnsemblGenomes-Gn:BSU39510" /db_xref="EnsemblGenomes-Tr:CAB15987" /db_xref="GOA:P54951" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11888" /db_xref="UniProtKB/Swiss-Prot:P54951" /translation="MKPRYRLAVERDAEQLLELTLRAYEPIRKLGIRFAAAHADLDLV LKNIRENACYVMEEDGRIIATITLRMPWGKQPGPYGVPHIWWFAVDPDTGKKGIGTKL LQWLEETILRDTLKVPFVSLGTADKHPWLIEMYERKGYVRSGEQDLGKGHITVYMKKQ LRHDL*" /label="snaB CDS" gene complement(3440673..3441170) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /label="snaB gene" CDS complement(3441184..3442509) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8892809, 12193636, 15294834, 16513748, 16885442, 23944997; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391831.1" /db_xref="EnsemblGenomes-Gn:BSU39520" /db_xref="EnsemblGenomes-Tr:CAB15988" /db_xref="GOA:P54950" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG11887" /db_xref="UniProtKB/Swiss-Prot:P54950" /translation="MTSKKKQIKLGVFLAGTGHHVASWRHPDAPSDASMNLDYFKELA KTAERGKLDMLFLADSLSIDSKSHPNVLTRFEPFTLLSALAQVTSKIGLTATASTTYS EPFHIARQFASLDHLSNGRAGWNVVTSSIESTALNFSGEKHLEHHLRYQRAEEFVEIV KGLWDSWEEDAFIRNKETGEFFDKEKMHELNHKGEYFSVRGPLNVSRTPQGQPVIIQA GSSGDGKALAAKTAEVIFTAQNHLESAQEFYQSIKEQAAEFGRDPEKIAIMPGIFPII ADTEEAAQAKYKELQDLIIPSVGLQILQNYLGGIDLSAYPLDGPLPKLDAEASNAVKS RFKLVQEMAERDNMTIRELYKYVAGSRGHHIFVGTPEQLADKMQEWVDTKACDGFNIM PPLLPEGIEVFVDQVVPILQERGVFRKEYEGTTLREHFGLEKPVNRYAK*" /label="yxeK CDS" gene complement(3441184..3442509) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /label="yxeK gene" promotor_-10 complement(3442586..3442605) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3442590) /Source="Nicolas_upshifts" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3442619..3442626) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3442695..3442922) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_391832.2" /db_xref="EnsemblGenomes-Gn:BSU39530" /db_xref="EnsemblGenomes-Tr:CAB15989" /db_xref="SubtiList:BG11886" /db_xref="UniProtKB/Swiss-Prot:P54949" /translation="MSLINSHQSADSGLNIWSQLFFYTIVTASEWIGGLQKRRKGKGN GEILYEIIGRKLSLCFIRLSFLADIEVALVE*" /label="yxeJ CDS" gene complement(3442695..3442922) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /label="yxeJ gene" CDS complement(3442909..3443895) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /EC_number="3.5.1.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15937167, 16511127, 18667582, 21978958" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937167, 16511127, 18667582, 21978958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin V amidase" /protein_id="NP_391833.2" /db_xref="EnsemblGenomes-Gn:BSU39540" /db_xref="EnsemblGenomes-Tr:CAB15990" /db_xref="GOA:P54948" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029132" /db_xref="PDB:2OQC" /db_xref="SubtiList:BG11885" /db_xref="UniProtKB/Swiss-Prot:P54948" /translation="MCTSLTLETADRKHVLARTMDFAFQLGTEVILYPRRYSWNSEAD GRAHQTQYAFIGMGRKLGNILFADGINESGLSCAALYFPGYAEYEKTIREDTVHIVPH EFVTWVLSVCQSLEDVKEKIRSLTIVEKKLDLLDTVLPLHWILSDRTGRNLTIEPRAD GLKVYDNQPGVMTNSPDFIWHVTNLQQYTGIRPKQLESKEMGGLALSAFGQGLGTVGL PGDYTPPSRFVRAVYLKEHLEPAADETKGVTAAFQILANMTIPKGAVITEEDEIHYTQ YTSVMCNETGNYYFHHYDNRQIQKVNLFHEDLDCLEPKVFSAKAEESIHELN*" /label="yxeI CDS" gene complement(3442909..3443895) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /label="yxeI gene" downshifts complement(3442913) /Source="Nicolas_upshifts" /id="D2046" /incds=0 /nref=7 /ntot=52 /MaxReadThrough="2.95669" /MaxDrop="3.32309" /score="23.0334771" /energy="-17.9" /TU="NA" /idTUdmin="U3113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3443046..3443055 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3443069..3443088 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3443079..3443712 /Source="Nicolas_S_feature" /locus_tag="new_4062713_4063346" /HighExp="S6, S7, S8, S5, Paraq, G150, H2O2, G180, LBGexp, Oxctl" /AntisenseName="yxeI" /AntisenseCor="0.24221971906572701" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S1520" upshifts 3443079 /Source="Nicolas_upshifts" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3443950..3443969) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3443961) /Source="Nicolas_upshifts" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3443984..3443991) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3444050..3444862) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 21575135, 23582330, 25527541, 25848029, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sugar-phosphate hydrolase (promiscuous)" /protein_id="NP_391834.1" /db_xref="EnsemblGenomes-Gn:BSU39550" /db_xref="EnsemblGenomes-Tr:CAB15991" /db_xref="GOA:P54947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11884" /db_xref="UniProtKB/Swiss-Prot:P54947" /translation="MYKLIAIDMDGTLLNDHHEVTEEVRDALHAAKAEGVKIVLCTGR PIGGVQRYLDELNLIEEGDYVIAYNGALVQNTHTNEVVSELSLGYDDLTSLYDLSLEL KTPMHFFDSSNLYTPNRDISEFTVYESYVTQVPLHFRKIDEVPKDILIPKVMFIDKPE NLSRVITSIPKDVREKYTMVRSAPFFYEILHSEASKGNAVRQLAQLLGIEQAEVMCIG DNGNDLTMIEWAGCGVAMANAIPEVLEAANFQTRSNNEHGVAHAIHELVLAK*" /label="hadM CDS" gene complement(3444050..3444862) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /label="hadM gene" promotor_-10 complement(3444892..3444911) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3444902..3445459) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391835.1" /db_xref="EnsemblGenomes-Gn:BSU39560" /db_xref="EnsemblGenomes-Tr:CAB15992" /db_xref="GOA:P54946" /db_xref="SubtiList:BG11883" /db_xref="UniProtKB/Swiss-Prot:P54946" /translation="MRNQKAERLVAAGLVLHIIQWIFILWAFLKVKHLFSDYTIYNPN VISGSMQSLSFIQMMRAMMYSGAIVNYVLFFALVLLIYGIVLHAILIVLEMAAYVMIR RNPSSSWGFFFIAAGVKLAILNITGIPFLAAGFLLMKQKKAENGVKAERKRKPRLRIR RQGRRLNRIRRKPSLPVEYQKEKTI*" /label="yxeG CDS" gene complement(3444902..3445459) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /label="yxeG gene" upshifts complement(3444915) /Source="Nicolas_upshifts" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3444926..3444933) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3445440..3445874) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /function="18: Unknown function" /experiment="publication(s) with functional evidences, PMID:11160890, 22693626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 22693626; Product type s: structure" /codon_start=1 /transl_table=11 /product="lipocalin-like lipoprotein" /protein_id="NP_391836.1" /db_xref="EnsemblGenomes-Gn:BSU39570" /db_xref="EnsemblGenomes-Tr:CAB15993" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR021664" /db_xref="PDB:2JOZ" /db_xref="SubtiList:BG11882" /db_xref="UniProtKB/Swiss-Prot:P54945" /translation="MVIPLRNKYGILFLIAVCIMVSGCQQQKEETPFYYGTWDEGRAP GPTDGVKSATVTFTEDEVVETEVMEGRGEVQLPFMAYKVISQSTDGSIEIQYLGPYYP LKSTLKRGENGTLIWEQNGQRKTMTRIESKTGREEKDEKSKS*" /label="yxeF CDS" gene complement(3445440..3445874) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /label="yxeF gene" promotor_-35 3445899..3445908 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3445918 /Source="Nicolas_upshifts" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3445921..3445940 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3445934) /Source="Nicolas_upshifts" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3445935..3446346) /Source="Nicolas_S_feature" /locus_tag="new_4065569_4065980_c" /HighExp="Salt, H2O2, Paraq, dia15, Oxctl, Diami, Cold, G150, Lbtran, LBGexp" /AntisenseName="yxeE" /AntisenseCor="-0.602938477548701" /AntisenseRegPval="-27.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.391, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1521" promotor_-10 complement(3445940..3445954) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3445963..3445967) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3445963..3446328 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 17905812, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 17905812, 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391837.1" /db_xref="EnsemblGenomes-Gn:BSU39580" /db_xref="EnsemblGenomes-Tr:CAB15994" /db_xref="SubtiList:BG11881" /db_xref="UniProtKB/Swiss-Prot:P54944" /translation="MNPYQYYSPQLPQQEPYYSHYEYNPYPQQDVYDPYQMDRQPALE RRIAALERQNEQQSRELTRLTNEDRRQNREIARIAEQVNQLSQAVERHTRRLNRLNQR LRTVENRLNIPFTAGEGGF*" /label="cotNE CDS" gene 3445963..3446328 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /label="cotNE gene" downshifts 3446342 /Source="Nicolas_upshifts" /id="D2047" /incds=0 /nref=31 /ntot=47 /MaxReadThrough="1.46494" /MaxDrop="8.36553" /score="27.2157513" /energy="-12.2" /TU="U3115" /idTUdmin="U3115" /TUdmin="-38" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3446346..3446350) /Source="Nicolas_upshift_promotors" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3446346) /Source="Nicolas_upshifts" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3446348..3446434) /Source="Nicolas_S_feature" /locus_tag="new_4065982_4066068_c" /HighExp="Salt, S8, H2O2, dia15, S7, Paraq, Diami, aero, Oxctl, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1522" promotor_-10 complement(3446427..3446446) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3446434) /Source="Nicolas_upshifts" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3446460..3446467) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3446507..3446513 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3446527..3446538 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3446534 /Source="Nicolas_upshifts" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="upshifts" CDS 3446576..3446929 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26506528" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391838.2" /db_xref="EnsemblGenomes-Gn:BSU39590" /db_xref="EnsemblGenomes-Tr:CAB15995" /db_xref="SubtiList:BG11880" /db_xref="UniProtKB/Swiss-Prot:P54943" /translation="MHNTQHGLQQLNQCRQTAQQLIQQTQQSSQQYRQMLHQEQQNIQ MLQQILNHEQQAAHTIQQALHGHDMAIQKCQQVVNMCNQMQQELTGQSSVMNTNVSTL PFGQNTTFQQQSYQQ*" /label="yxeD CDS" gene 3446576..3446929 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /label="yxeD gene" downshifts 3446924 /Source="Nicolas_upshifts" /id="D2048" /incds=0 /nref=24 /ntot=55 /MaxReadThrough="0.20641" /MaxDrop="6.88486" /score="27.2157513" /energy="-12.2" /TU="NA" /idTUdmin="U3119" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(3446973..3447371) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391839.2" /db_xref="EnsemblGenomes-Gn:BSU39600" /db_xref="EnsemblGenomes-Tr:CAB15996" /db_xref="GOA:P54942" /db_xref="SubtiList:BG11879" /db_xref="UniProtKB/Swiss-Prot:P54942" /translation="MGITKRGAAWEWLHSWWMLFIFMPFAITSFFAFLFIGIKVRNRK WIMYGIIYFFIFAFGFVLPDLPGVFIVVPLWAVTIIHGFKVRPLYLIQLDVYKDHVEA RAFAEARSEAESRFHAPKQSIQDIHIRKEQ*" /label="yxeC CDS" gene complement(3446973..3447371) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /label="yxeC gene" downshifts complement(3446981) /Source="Nicolas_upshifts" /id="D2049" /incds=0 /nref=145 /ntot=243 /MaxReadThrough="1.70512" /MaxDrop="5.26494" /score="9.81431167" /energy="-12.2" /TU="NA" /idTUdmin="U3120" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3447386..3447405) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3447402) /Source="Nicolas_upshifts" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3447420..3447423) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3447459..3447466 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3447475..3447493) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3447481..3447500 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3447490 /Source="Nicolas_upshifts" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3447490) /Source="Nicolas_upshifts" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3447509..3447514) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3447549..3448514 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 16672620, 8388528, 19254027, 23924612, 25007174; Product type t : transporter" /codon_start=1 /transl_table=11 /product="desferrioxamine-and ferrichrome-binding transporter lipoprotein (shuttle system)" /protein_id="NP_391840.2" /db_xref="EnsemblGenomes-Gn:BSU39610" /db_xref="EnsemblGenomes-Tr:CAB15997" /db_xref="GOA:P54941" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG11878" /db_xref="UniProtKB/Swiss-Prot:P54941" /translation="MKKNILLVGMLVLLLMFVSACSGTASKGSSSDSASEKTEMRTYK SPKGNVNIPAHPKRIVTDFYAGELLSVGANVVGSGSWSFDNPFLKSKLKNVKDVGDPI SVEKVMELQPDLIVVMNEENVDKLKKIAPTVVIPYNTAKNVEDTVSMFGDIAGAKDQA KSFMADFNKKAEAAKKKIAGVIDKDATFGIYENTDKGEFWVFNDNGGRGGQAVYNALG LKAPEKIEQDVIKKGEMKQLSQEVIPEYAADYMFITDYNPKGESKTLDKLENSSIWKN LDAVKHNRVFINDFDSFYPYDPISVSKQVDIITDMLIKRAEENKK*" /label="frxB CDS" gene 3447549..3448514 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /label="frxB gene" upshifts 3447942 /Source="Nicolas_upshifts" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3447949..3447967 /Source="Nicolas_upshift_promotors" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3448421 /Source="Nicolas_upshifts" /id="D2050" /incds=1 /nref=55 /ntot=191 /MaxReadThrough="6.103" /MaxDrop="4.3334" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=193 /isTUend="FALSE" /label="downshifts" downshifts 3448492 /Source="Nicolas_upshifts" /id="D2051" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="4.41732" /MaxDrop="3.7101" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=264 /isTUend="FALSE" /label="downshifts" S_feature 3448537..3449333 /Source="Nicolas_S_feature" /locus_tag="new_4068171_4068967" /HighExp="H2O2, Paraq, Lbexp, dia0, LBGexp, G150, B36, dia15, B60, GM 25" /AntisenseName="yxeA" /AntisenseCor="0.20524492145617201" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1523" CDS complement(3448555..3448902) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391841.1" /db_xref="EnsemblGenomes-Gn:BSU39620" /db_xref="EnsemblGenomes-Tr:CAB15998" /db_xref="InterPro:IPR006542" /db_xref="InterPro:IPR036166" /db_xref="PDB:3NPP" /db_xref="SubtiList:BG11877" /db_xref="UniProtKB/Swiss-Prot:P54940" /translation="MKKAMAILAVLAAAAVICGLLFFHNDVTDRFNPFIHQQDVYVQI DRDGRHLSPGGTEYTLDGYNASGKKEEVTFFAGKELRKNAYLKVKAKGKYVETWEEVK FEDMPDSVQSKLK*" /label="yxeA CDS" gene complement(3448555..3448902) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /label="yxeA gene" downshifts complement(3448568) /Source="Nicolas_upshifts" /id="D2052" /incds=0 /nref=2 /ntot=78 /MaxReadThrough="1.28842" /MaxDrop="2.99568" /score="38.5550476" /energy="-11.6" /TU="NA" /idTUdmin="U3120" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(3448916..3450784) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15849754, 15870467, 16850406, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15849754, 15870467, 16850406, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease); efflux of cationic peptides" /protein_id="NP_391842.2" /db_xref="EnsemblGenomes-Gn:BSU39630" /db_xref="EnsemblGenomes-Tr:CAB15999" /db_xref="GOA:P42424" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG11129" /db_xref="UniProtKB/Swiss-Prot:P42424" /translation="MTFLQFAYKNVTRNKRAYLAFFLSSAFSVLIFFTFAMFLFHPAL KEGYLNNIAKKGLTAAEWMIFVFSFLFVLYSVNAFLKSRNKEFGILLMQGITPGQLRK LITAENMIIGVMSIAAGIIGGFIFSKTFFTVGAYILEMDALPLYMPWKALGITACGFL LLFFFLSQFTILFVRSNTVIKLIKGTGKVKPEPKPSVLLSLFGIACLCGGYGMVLKGN VHGAEPFIILLLTVIGTYFFFSQSSIWILRALKKWKTFYLRGKNIIWVSDLVYRLKDN ARLFFIVSIISAVAFTATGVLAMYKSTVGAEESAYEMEYLSYSNNPKEQTHLKDIDHE LKTHGFTYTKDKIDVSYVRYQEGETVPPVYMISESDAAKYFHVKVNGLKEDEAVYFPG TYDRNFKNEAPDQLKLLNQKGELSDQKLSVKEVKKPLISLNAIIAVNDQTFDQLKSLG DKASLYGYSYDHWKDSLEISQSLQNEIYGNYIDVHSDFASKAGTYYDTVQLPSLSLFI GLFIAIVFFVAAASFLYFRLFTDLDEDRERYRSLAKIGLSEREMAQSVTIQLAILFFF PFVIAVMHTLFALRTLAVEGYSDVAGPLSLTIGGFFIFQLLFFLAVRSSYLKKMNK*" /label="tpeM CDS" gene complement(3448916..3450784) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /label="tpeM gene" CDS complement(3450759..3451532) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15870467, 17600057, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15870467, 17600057, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein); efflux ofcationic peptides" /protein_id="NP_391843.2" /db_xref="EnsemblGenomes-Gn:BSU39640" /db_xref="EnsemblGenomes-Tr:CAB16000" /db_xref="GOA:P42423" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11128" /db_xref="UniProtKB/Swiss-Prot:P42423" /translation="MANMLEVKHINKTYKGQVSYQALKQISFSIEEGEFTAVMGPSGS GKTTLLNIISTIDRPDSGDILINGENPHRLKRTKLAHFRRKQLGFVFQDFNLLDTLTI GENIMLPLTLEKEAPSVMEEKLHGIAAKLGIENLLNKRTFEVSGGQRQRAAIARAVIH KPSLILADEPTGNLDSKATKDVMETLQSLNRDDHVTALMVTHDPVSASYCRRVIFIKD GELFNEIYRGENRQVFYEQILDVLSMLGGNANDLSSVRL*" /label="tpeL CDS" gene complement(3450759..3451532) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /label="tpeL gene" CDS complement(3451676..3452653) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxdJ]" /protein_id="NP_391844.1" /db_xref="EnsemblGenomes-Gn:BSU39650" /db_xref="EnsemblGenomes-Tr:CAB16001" /db_xref="GOA:P42422" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11127" /db_xref="UniProtKB/Swiss-Prot:P42422" /translation="MKLFLRSHAVLILLFLLQGLFVFFYYWFAGLHSFSHLFYILGVQ LLILAGYLAYRWYKDRGVYHWLSSGQEGTDIPYLGSSVFCSELYEKQMELIRLQHQKL HETEAKLDARVTYMNQWVHQVKTPLSVINLIIQEEDEPVFEQIKKEVRQIEFGLETLL YSSRLDLFERDFKIEAVSLSELLQSVIQSYKRFFIQYRVYPKMNVCDDHQIYTDAKWL KFAIGQVVTNAVKYSAGKSDRLELNVFCDEDRTVLEVKDYGVGIPSQDIKRVFDPYYT GENGRRFQESTGIGLHLVKEITDKLNHTVDISSSPGEGTSVRFSFLTKM*" /label="tpeK CDS" gene complement(3451676..3452653) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /label="tpeK gene" CDS complement(3452650..3453339) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [TpeK(YxdK)]" /protein_id="NP_391845.1" /db_xref="EnsemblGenomes-Gn:BSU39660" /db_xref="EnsemblGenomes-Tr:CAB16002" /db_xref="GOA:P42421" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11126" /db_xref="UniProtKB/Swiss-Prot:P42421" /translation="MNKIMIVEDSEDIRGLLQNYLEKYGYQTVVAADFTAVLDVFLRE KPDVVLLDINLPAYDGYYWCRQIRQHSTSPIIFISARSGEMDQVMAIENGGDDYIEKP FSYDIVLAKIKSQIRRAYGEYAAKQGEKVVEYAGVQLFVERFELRFQDEKSELSKKES KLLEVLLERGEKVTSRDRLMEKTWDTDIFIDDNTLNVYITRLRKKLRELNAPVSIEAV RGEGYQLRAQS*" /label="tpeJ CDS" gene complement(3452650..3453339) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /label="tpeJ gene" promotor_-10 complement(3453366..3453385) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3453384) /Source="Nicolas_upshifts" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3453400..3453406) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3453447..3454319) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /EC_number="4.1.2.29" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 10658656, 11325924, 18310071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 10658656, 11325924, 18310071; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid 6-phosphate aldolase" /protein_id="NP_391846.1" /db_xref="EnsemblGenomes-Gn:BSU39670" /db_xref="EnsemblGenomes-Tr:CAB16003" /db_xref="GOA:P42420" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11125" /db_xref="UniProtKB/Swiss-Prot:P42420" /translation="MAFVSMKELLEDAKREQYAIGQFNINGLQWTKAILQAAQKEQSP VIAAASDRLVDYLGGFKTIAAMVGALIEDMAITVPVVLHLDHGSSAERCRQAIDAGFS SVMIDGSHQPIDENIAMTKEVTDYAAKHGVSVEAEVGTVGGMEDGLVGGVRYADITEC ERIVKETNIDALAAALGSVHGKYQGEPNLGFKEMEAISRMTDIPLVLHGASGIPQDQI KKAITLGHAKININTECMVAWTDETRRMFQENSDLYEPRGYLTPGIEAVEETVRSKMR EFGSAGKAAKQQVG*" /label="iolJ CDS" gene complement(3453447..3454319) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /label="iolJ gene" downshifts complement(3453451) /Source="Nicolas_upshifts" /id="D2053" /incds=0 /nref=89 /ntot=172 /MaxReadThrough="3.05314" /MaxDrop="6.87265" /score="26.7325466" /energy="-8.2" /TU="NA" /idTUdmin="U3126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3454340..3455176) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /EC_number="5.3.99.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inosose isomerase" /protein_id="NP_391847.1" /db_xref="EnsemblGenomes-Gn:BSU39680" /db_xref="EnsemblGenomes-Tr:CAB16004" /db_xref="GOA:P42419" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="PDB:1I60" /db_xref="PDB:1I6N" /db_xref="SubtiList:BG11124" /db_xref="UniProtKB/Swiss-Prot:P42419" /translation="MKLCFNEATTLENSNLKLDLELCEKHGYDYIEIRTMDKLPEYLK DHSLDDLAEYFQTHHIKPLALNALVFFNNRDEKGHNEIITEFKGMMETCKTLGVKYVV AVPLVTEQKIVKEEIKKSSVDVLTELSDIAEPYGVKIALEFVGHPQCTVNTFEQAYEI VNTVNRDNVGLVLDSFHFHAMGSNIESLKQADGKKIFIYHIDDTEDFPIGFLTDEDRV WPGQGAIDLDAHLSALKEIGFSDVVSVELFRPEYYKLTAEEAIQTAKKTTVDVVSKYF SM*" /label="iolI CDS" gene complement(3454340..3455176) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /label="iolI gene" S_feature complement(3455177..3455261) /Source="Nicolas_S_feature" /locus_tag="new_4074811_4074895_c" /HighExp="M40t90, M0t90, BI, Sw, BC, T5.0H, T0.30H, T4.0H, T3.30H, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.101524" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1524" CDS complement(3455262..3456131) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9887260, 11566986, 12112707, 23874669; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_391848.1" /db_xref="EnsemblGenomes-Gn:BSU39690" /db_xref="EnsemblGenomes-Tr:CAB16005" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11123" /db_xref="UniProtKB/Swiss-Prot:P42418" /translation="MKLALDPSMYRDDLTLEEMVYKTAELGYEYIELSPREDFCPFYK YPKVDSAKIKQLKRLLRDTGVKLSSLLPLYHWAGPDEDRRQAAVRNWKRAIEIAVELE VDLMNSEFSGSKYDPLTSEEKFIKSMDELLPVFEKEGIKLNLQAHPYDFIETHKGAMD MIRALDKDWINLVYSTAHTFFYDDGKGDIETMFDEAGDRLTHVLFADTYNHKAAHGLR YIVNPPDAKVTVHQHLDIGQGEVDFDTIFRKLREMKFDGIATNAVFAWVDERADESSR FMLKKMKEELGLA*" /label="iolH CDS" gene complement(3455262..3456131) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /label="iolH gene" CDS complement(3456151..3457185) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /EC_number="1.1.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase" /protein_id="NP_391849.2" /db_xref="EnsemblGenomes-Gn:BSU39700" /db_xref="EnsemblGenomes-Tr:CAB16006" /db_xref="GOA:P26935" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR023794" /db_xref="InterPro:IPR036291" /db_xref="PDB:3MZ0" /db_xref="PDB:3NT2" /db_xref="PDB:3NT4" /db_xref="PDB:3NT5" /db_xref="PDB:3NTO" /db_xref="PDB:3NTQ" /db_xref="PDB:3NTR" /db_xref="PDB:4L8V" /db_xref="PDB:4L9R" /db_xref="SubtiList:BG10669" /db_xref="UniProtKB/Swiss-Prot:P26935" /translation="MSLRIGVIGTGAIGKEHINRITNKLSGAEIVAVTDVNQEAAQKV VEQYQLNATVYPNDDSLLADENVDAVLVTSWGPAHESSVLKAIKAQKYVFCEKPLATT AEGCMRIVEEEIKVGKRLVQVGFMRRYDSGYVQLKEALDNHVIGEPLMIHCAHRNPTV GDNYTTDMAVVDTLVHEIDVLHWLVNDDYESVQVIYPKKSKNALPHLKDPQIVVIETK GGIVINAEIYVNCKYGYDIQCEIVGEDGIIKLPEPSSISLRKEGRFSTDILMDWQRRF VAAYDVEIQDFIDSIQKKGEVSGPTAWDGYIAAVTTDACVKAQESGQKEKVELKEKPE FYQSFTTVQN*" /label="iolG CDS" gene complement(3456151..3457185) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /label="iolG gene" CDS complement(3457208..3458524) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="inositol transport protein" /protein_id="NP_391850.2" /db_xref="EnsemblGenomes-Gn:BSU39710" /db_xref="EnsemblGenomes-Tr:CAB16007" /db_xref="GOA:P42417" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11122" /db_xref="UniProtKB/Swiss-Prot:P42417" /translation="MGNTNGDSAFNKRTIAAALANYIDAGSIVAGSAGLSLWVSYLKL SDTQIGLLGALSANAISAAVGALLGGFLADKVGRKAVYTNSMLVYALGICLVLFGVNF PMLLSGYIIIGLSVGADITASWTIIAENAPKKNRARHCGVAQVAWAAGAVVVLLLSVL AGDLGLLGNKIVFAHLLVIALITYILRIRLPESDAWQTKNQPEEAQAEKPAVLNKTSY FDLLKPMYLKSILFLMGVYLVWNLAAGVMGFFMPYIYQQVGGVSANMANLLQMGLFIF TGLGVALIFMPFADKYRKTVFGIAAFMAVIGWTLFLLPVEGLPILLLFIVVIGINNGA GQQANYQLWASEIFPTQYRASAQGLMFFLVRISIGIWSLFVPMIITNFGIGTMAAILL GCVTASMIIGLLFAPNTSGKSLEQIQEELYGSPQSQVKKGTESKIM*" /label="iolF CDS" gene complement(3457208..3458524) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /label="iolF gene" CDS complement(3458539..3459432) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /EC_number="4.2.1.44" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 14993306, 22720735, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 14993306, 22720735, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inosose dehydratase" /protein_id="NP_391851.1" /db_xref="EnsemblGenomes-Gn:BSU39720" /db_xref="EnsemblGenomes-Tr:CAB16008" /db_xref="GOA:P42416" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR023952" /db_xref="InterPro:IPR030823" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11121" /db_xref="UniProtKB/Swiss-Prot:P42416" /translation="MGKNEILWGIAPIGWRNDDMPEIGAGNTLQHLLSDIVVARFQGT EVGGFFPEPAILNKELKLRNLRIAGKWFSSFILRDGLGEAAKTFTLHCEYLQQVNADV AVVSEQTYSVQSLEKNVFTEKPHFTDDEWERLCEGLNHLGEIAAQHGLKLVYHHHLGT GVQTAEEVDRLMAGTDPAHVHLLYDTGHAYISDGDYMGMLEKHIGRIKHVHFKDARLN VMEQCRLEGQSFRQSFLKGMFTVPGDGCIDFREVYQLLLKHSYSGWIVIEAEQDPDVA NPLEYALIARNYIDQQLLDLA*" /label="iolE CDS" gene complement(3458539..3459432) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /label="iolE gene" CDS complement(3459449..3461362) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /EC_number="3.7.1.22" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase" /protein_id="NP_391852.2" /db_xref="EnsemblGenomes-Gn:BSU39730" /db_xref="EnsemblGenomes-Tr:CAB16009" /db_xref="GOA:P42415" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR023757" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR030817" /db_xref="SubtiList:BG11120" /db_xref="UniProtKB/Swiss-Prot:P42415" /translation="MGKKIRLTTAQALIKFLNQQYIHVDGKEEPFVEGIFTIFGHGNV LGIGQALEQDAGHLKVYQGKNEQGMAHAAMAYSKQMLRRKIYAVSTSVGPGAANLVAA AGTALANNIPVLLIPADTFATRQPDPVLQQMEQEYSAAITTNDALKPVSRYWDRITRP EQLMSSLLRAFEVMTDPAKAGPATICISQDVEGEAYDFDESFFVKRVHYIDRMQPSER ELQGAAELIKSSKKPVILVGGGAKYSGARDELVAISEAYNIPLVETQAGKSTVEADFA NNLGGMGITGTLAANKAARQADLIIGIGTRYTDFATSSKTAFDFDKAKFLNINVSRMQ AYKLDAFQVVADAKVTLGKLHGLLEGYESEFGTTIRELKDEWLAERERLSKVTFKREA FDPEIKNHFSQEVLNEYADALNTELPQTTALLTINETIPEDSVIICSAGSLPGDLQRL WHSNVPNTYHLEYGYSCMGYEVSGTLGLKLAHPDREVYSIVGDGSFLMLHSELITAIQ YNKKINVLLFDNSGFGCINNLQMDHGSGSYYCEFRTDDNQILNVDYAKVAEGYGAKTY RANTVEELKAALEDAKKQDVSTLIEMKVLPKTMTDGYDSWWHVGVAEVSEQESVQKAY EAKEKKLESAKQY*" /label="iolD CDS" gene complement(3459449..3461362) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /label="iolD gene" CDS complement(3461395..3462372) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /EC_number="2.7.1.92" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid kinase" /protein_id="NP_391853.1" /db_xref="EnsemblGenomes-Gn:BSU39740" /db_xref="EnsemblGenomes-Tr:CAB16010" /db_xref="GOA:P42414" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR022841" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="InterPro:IPR030830" /db_xref="SubtiList:BG11119" /db_xref="UniProtKB/Swiss-Prot:P42414" /translation="MKYTFNEEKAFDIVAIGRACIDLNAVEYNRPMEETMTFSKYVGG SPANIAIGSAKLGLKAGFIGKIPDDQHGRFIESYMRKTGVDTTQMIVDQDGHKAGLAF TEILSPEECSILMYRDDVADLYLEPSEVSEDYIANAKMLLVSGTALAKSPSREAVLKA VQYAKKHQVKVVFELDYRPYTWQSSDETAVYYSLVAEQSDIVIGTRDEFDVMENRTGG SNEESVNHLFGHSADLVVIKHGVEGSYAYSKSGEVFRAQAYKTKVLKTFGAGDSYASA FIYGLVSGKDIETALKYGSASASIVVSKHSSSEAMPTAEEIEQLIEAQS*" /label="iolC CDS" gene complement(3461395..3462372) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /label="iolC gene" CDS complement(3462396..3463211) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /EC_number="5.3.1.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-deoxy-D-glucuronic acid isomerase" /protein_id="NP_391854.2" /db_xref="EnsemblGenomes-Gn:BSU39750" /db_xref="EnsemblGenomes-Tr:CAB16011" /db_xref="GOA:P42413" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR023770" /db_xref="InterPro:IPR024203" /db_xref="SubtiList:BG11118" /db_xref="UniProtKB/Swiss-Prot:P42413" /translation="MSYLLRKPQSHEVSNGVKLVHEVTTSNSDLTYVEFKVLDLASGS SYTEELKKQEICIVAVTGKITVTDHESTFENIGTRESVFERKPTDSVYISNDRAFEIT AVSDARVALCYSPSEKQLPTKLIKAEDNGIEHRGQFSNKRTVHNILPDSDPSANSLLV VEVYTDSGNWSSYPPHKHDQDNLPEESFLEETYYHELDPGQGFVFQRVYTDDRSIDET MTVGNENVVIVPAGYHPVGVPDGYTSYYLNVMAGPTRKWKFYNDPAHEWILER*" /label="iolB CDS" gene complement(3462396..3463211) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /label="iolB gene" S_feature complement(3463212..3463285) /Source="Nicolas_S_feature" /locus_tag="new_4082846_4082919_c" /HighExp="M40t90, M0t90, Lbtran, BI, Mt0, T0.30H, Sw, BC, S1, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1525" CDS complement(3463286..3464749) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /EC_number="1.2.1.27" /EC_number="1.2.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylmalonate-semialdehyde dehydrogenase" /protein_id="NP_391855.1" /db_xref="EnsemblGenomes-Gn:BSU39760" /db_xref="EnsemblGenomes-Tr:CAB16012" /db_xref="GOA:P42412" /db_xref="InterPro:IPR010061" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR023510" /db_xref="PDB:1T90" /db_xref="SubtiList:BG11117" /db_xref="UniProtKB/Swiss-Prot:P42412" /translation="MAEIRKLKNYINGEWVESKTDQYEDVVNPATKEVLCQVPISTKE DIDYAAQTAAEAFKTWSKVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEAL GEVGRGIENVEFAAGAPSLMMGDSLASIATDVEAANYRYPIGVVGGIAPFNFPMMVPC WMFPMAIALGNTFILKPSERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNGILEH PEIKAISFVGSKPVGEYVYKKGSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAA FGSAGERCMACAVVTVEEGIADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKR TLSYIEKGLEEGARLVCDGRENVSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIR VKNLKEAIEIANKSEFANGACLFTSNSNAIRYFRENIDAGMLGINLGVPAPMAFFPFS GWKSSFFGTLHANGKDSVDFYTRKKVVTARYPAPDFN*" /label="iolA CDS" gene complement(3463286..3464749) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /label="iolA gene" S_feature complement(3464750..3464954) /Source="Nicolas_S_feature" /locus_tag="new_4084384_4084588_c" /HighExp="M0t90, M40t90, Lbtran, BI, Mt0, T0.30H, BC, S1, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1526" promotor_-35 3464753..3464760 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-35" promotor_-10 3464776..3464795 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-10" upshifts 3464783 /Source="Nicolas_upshifts" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="upshifts" S_feature 3464790..3465096 /Source="Nicolas_S_feature" /locus_tag="new_4084424_4084730" /HighExp="G180, Paraq, G150, Oxctl, H2O2, G135, Diami, LBGexp, dia5, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.788" /TUlongSig="NA" /TUlongPSig="NA" /label="S1527" promotor_-10 complement(3464936..3464955) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3464954) /Source="Nicolas_upshifts" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3464956..3465108) /Source="Nicolas_S_feature" /locus_tag="new_4084590_4084742_c" /HighExp="M40t90, M0t90, Lbtran, Diami, Heat, dia5, C30, BI, S1, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1528" promotor_-35 complement(3464970..3464977) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3465056..3465063 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-35" promotor_-10 3465078..3465097 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-10" upshifts 3465098 /Source="Nicolas_upshifts" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="upshifts" promotor_-10 complement(3465109..3465128) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-10" upshifts complement(3465125) /Source="Nicolas_upshifts" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="upshifts" promotor_-35 complement(3465144..3465151) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-35" CDS 3465165..3465920 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 11807058, 18310071, 24878601, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 11807058, 18310071, 24878601, 26735940; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the iol operon (DeoR family)" /protein_id="NP_391856.1" /db_xref="EnsemblGenomes-Gn:BSU39770" /db_xref="EnsemblGenomes-Tr:CAB16013" /db_xref="GOA:P46337" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11364" /db_xref="UniProtKB/Swiss-Prot:P46337" /translation="MKLMRIQEMEEYILSHGTVSLDELCQVFNVSKNTVRRDINKLTE KGAIEKVYGGVTSIEKTALVPFENRTIQHQDEKTKIAHYASRFIEDHDLVFIDSGTTT KSILDTLDPAKNVTILTNSLDIINAASALKNINLIIIGNNYKRKTRSFVGMDDPAMLD KYNINKAFMSATGTTLTHGLTNSDLLEYEIKKRISEKAKEVYLLADHSKFGKSTLLTY APFDRLHCIVTSQPLDDEYTQYCNEHQIGIHLA*" /label="iolR CDS" gene 3465165..3465920 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /label="iolR gene" promotor_-35 3465899..3465905 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3465920..3465939 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3465934 /Source="Nicolas_upshifts" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="upshifts" CDS 3465974..3466906 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9226270, 15019785, 22720735, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_391857.1" /db_xref="EnsemblGenomes-Gn:BSU39780" /db_xref="EnsemblGenomes-Tr:CAB16014" /db_xref="GOA:P46336" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PYF" /db_xref="PDB:1PZ0" /db_xref="SubtiList:BG11363" /db_xref="UniProtKB/Swiss-Prot:P46336" /translation="MKKAKLGKSDLQVFPIGLGTNAVGGHNLYPNLNEETGKELVREA IRNGVTMLDTAYIYGIGRSEELIGEVLREFNREDVVIATKAAHRKQGNDFVFDNSPDF LKKSVDESLKRLNTDYIDLFYIHFPDEHTPKDEAVNALNEMKKAGKIRSIGVSNFSLE QLKEANKDGLVDVLQGEYNLLNREAEKTFFPYTKEHNISFIPYFPLVSGLLAGKYTED TTFPEGDLRNEQEHFKGERFKENIRKVNKLAPIAEKHNVDIPHIVLAWYLARPEIDIL IPGAKRADQLIDNIKTADVTLSQEDISFIDKLFA*" /label="iolS CDS" gene 3465974..3466906 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /label="iolS gene" downshifts 3466908 /Source="Nicolas_upshifts" /id="D2054" /incds=0 /nref=154 /ntot=259 /MaxReadThrough="4.521" /MaxDrop="7.17874" /score="39.70215" /energy="-17.1" /TU="U3129" /idTUdmin="U3127" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-35 3466985..3466992 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3467006..3467025 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3467012..3467167 /Source="Nicolas_S_feature" /locus_tag="new_4086646_4086801" /HighExp="dia5, LPhT, Diami, Etha, dia15, LBGstat, M9-stat, Lbtran, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.835, 0.994" /TUlongSig="SigA" /TUlongPSig="0.99" /label="S1529" upshifts 3467012 /Source="Nicolas_upshifts" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="upshifts" CDS 3467168..3467818 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391858.1" /db_xref="EnsemblGenomes-Gn:BSU39790" /db_xref="EnsemblGenomes-Tr:CAB16015" /db_xref="GOA:P46335" /db_xref="SubtiList:BG11362" /db_xref="UniProtKB/Swiss-Prot:P46335" /translation="MKLKYVKALVAVTVALGVLLPSTISHAKSFSGRSSSSYSSRSSS SSYSGSYKSSPKSSYSSGSSSSSKKSKTSDDSSSSISLKKKPSEKASSSSSKKSSGTF SGATSKVTGKTYSGKTSKAYVGGRYVSVNHYYHAGFAPSGWFGYYSGFTMGMFMISMM HPWGYTYHPVGGPGYVSYGASPIAWIVDIIALIIILIIVIALIRAFKAPKTYRRRF*" /label="yxcE CDS" gene 3467168..3467818 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /label="yxcE gene" CDS 3467822..3468130 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391859.1" /db_xref="EnsemblGenomes-Gn:BSU39800" /db_xref="EnsemblGenomes-Tr:CAB16016" /db_xref="InterPro:IPR020516" /db_xref="SubtiList:BG11361" /db_xref="UniProtKB/Swiss-Prot:P46334" /translation="MRLILNEQEIVDGICVYISNEEDIYPEDVEVKELSYNKRTGFFA EATFGLHHKQLMSDDISEGIIQFLEEYHNFNPDVTVVELQFDKKKGFSALVFVNEAEE *" /label="yxcD CDS" gene 3467822..3468130 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /label="yxcD gene" downshifts 3468132 /Source="Nicolas_upshifts" /id="D2055" /incds=0 /nref=185 /ntot=262 /MaxReadThrough="1.91541" /MaxDrop="6.4314" /score="14.1581732" /energy="-8.8" /TU="NA" /idTUdmin="U3130" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 3468274..3468280 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3468296..3468314 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3468306 /Source="Nicolas_upshifts" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="upshifts" CDS 3468368..3469753 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391860.1" /db_xref="EnsemblGenomes-Gn:BSU39810" /db_xref="EnsemblGenomes-Tr:CAB16017" /db_xref="GOA:P46333" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11360" /db_xref="UniProtKB/Swiss-Prot:P46333" /translation="MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTL TEGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIA SRVILGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFE AWRWMVGLAAVPAVLLLIGIAFMPESPRWLVKRGSEEEARRIMNITHDPKDIEMELAE MKQGEAEKKETTLGVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGT SASALGTMGIGILNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLS ASTAWMTVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSAANLIVS LVFPLMLSAMGIAWVFMVFSVICLLSFFFAFYMVPETKGKSLEEIEASLKKRFKKKKS TQNQVLNERTL*" /label="csbC CDS" gene 3468368..3469753 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /label="csbC gene" downshifts 3469739 /Source="Nicolas_upshifts" /id="D2056" /incds=0 /nref=69 /ntot=115 /MaxReadThrough="4.59405" /MaxDrop="7.32264" /score="22.9943012" /energy="-16.4" /TU="NA" /idTUdmin="U3131" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 3469784..3470334 /Source="Nicolas_S_feature" /locus_tag="new_4089418_4089968" /HighExp="Etha, C30, C90, Gly, Sw, G135, Fru, HiTm, M/G, Mal" /AntisenseName="htpG" /AntisenseCor="7.4766600377621104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1530" CDS complement(3469795..3471675) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III heat-shock protein (ATP-dependent molecular chaperone HSP90)" /protein_id="NP_391861.1" /db_xref="EnsemblGenomes-Gn:BSU39820" /db_xref="EnsemblGenomes-Tr:CAB16018" /db_xref="GOA:P46208" /db_xref="InterPro:IPR001404" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR019805" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020575" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037196" /db_xref="SubtiList:BG11359" /db_xref="UniProtKB/Swiss-Prot:P46208" /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIY YKALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAF KKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPC EKDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEG SENEFEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGA VRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSED LSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVY NDFGANKDQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQT EMVADKGYEILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESK YKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAE KVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKV MV*" /label="htpG CDS" gene complement(3469795..3471675) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /label="htpG gene" downshifts complement(3469801) /Source="Nicolas_upshifts" /id="D2057" /incds=0 /nref=169 /ntot=288 /MaxReadThrough="0.81611" /MaxDrop="6.49379" /score="34.0973015" /energy="-16.4" /TU="NA" /idTUdmin="U3132" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" S_feature complement(3471676..3471773) /Source="Nicolas_S_feature" /locus_tag="new_4091310_4091407_c" /HighExp="Lbtran, S1, LBGtran, C90, M40t45, M9-tran, GM 150, dia0, T-2.40H, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="SigA" /TUlongPSig="0.995" /label="S1531" promotor_-10 complement(3471764..3471783) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3471773) /Source="Nicolas_upshifts" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3471798..3471805) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3471843..3472094) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391862.1" /db_xref="EnsemblGenomes-Gn:BSU39830" /db_xref="EnsemblGenomes-Tr:CAB16019" /db_xref="GOA:P46332" /db_xref="SubtiList:BG11358" /db_xref="UniProtKB/Swiss-Prot:P46332" /translation="MKVQHKKELKFYCIVTIPSAFVVLTVISFLLQEITFPVTASAFL NASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG*" /label="yxcA CDS" gene complement(3471843..3472094) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /label="yxcA gene" downshifts complement(3471861) /Source="Nicolas_upshifts" /id="D2058" /incds=0 /nref=11 /ntot=62 /MaxReadThrough="3.50049" /MaxDrop="5.56962" /score="-3.89567108" /energy="-6.7" /TU="U3133" /idTUdmin="U3133" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" misc_feature complement(3472116..3472135) /Source="Nicolas_upshift_promotors" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3472125) /Source="Nicolas_upshifts" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="upshifts" promotor_-35 3472158..3472164 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3472178..3472196 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3472179 /Source="Nicolas_upshifts" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="upshifts" CDS 3472211..3473032 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391863.2" /db_xref="EnsemblGenomes-Gn:BSU39840" /db_xref="EnsemblGenomes-Tr:CAB16020" /db_xref="GOA:P46331" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11357" /db_xref="UniProtKB/Swiss-Prot:P46331" /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQME ETVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHE YPVDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKG GITNLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEQFREANKWITPL GRLGQPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIEEKWKEETK*" /label="yxbG CDS" gene 3472211..3473032 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /label="yxbG gene" downshifts 3473016 /Source="Nicolas_upshifts" /id="D2059" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="2.87575" /MaxDrop="5.67438" /score="22.9485028" /energy="-10.5" /TU="U3134" /idTUdmin="U3134" /TUdmin="-221" /isTUend="FALSE" /label="downshifts" CDS complement(3473061..3474203) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11160890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391864.1" /db_xref="EnsemblGenomes-Gn:BSU39850" /db_xref="EnsemblGenomes-Tr:CAB16021" /db_xref="GOA:P46330" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG11356" /db_xref="UniProtKB/Swiss-Prot:P46330" /translation="MPESAEAQVKEALLALLKDRDIQHITMKEIAEKAKVSRGSLYLY YEDKFSIIEDVIEDMKEGLGKALFDAFSHMDTLHLNKKRQTVHPTLSFVHEHRSFFSV MMNRGHFHRFFKDVFQQDVLLAPIHVNLTPIERDIYGHYRALYTYAIILYWLNEDAAA SPEAISQKVWELVSQKRFYWLFGKAVPGEREKEKQIDRRVVRTREALQKAFLDVLAEK QDYAGITISDITRKSNIRRATFYDHYANKEELLQTMIQRSCAEIIDHLTIASSPNEFS LKEAEKALAILLSALSNMPIVHFLNREWGVPHVIPDMFKALESFYLHQQTDIHAEKKL YAHYVSAMIIGLLLYRLDEGKAHPPEVLAREFLQFLDVKKYKVVLL*" /label="yxbF CDS" gene complement(3473061..3474203) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /label="yxbF gene" downshifts complement(3473071) /Source="Nicolas_upshifts" /id="D2060" /incds=0 /nref=10 /ntot=163 /MaxReadThrough="1.63217" /MaxDrop="3.79969" /score="-0.564494299" /energy="-10.5" /TU="NA" /idTUdmin="U3135" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3474204..3474303) /Source="Nicolas_S_feature" /locus_tag="new_4093838_4093937_c" /HighExp="H2O2, Diami, dia15, Paraq, G180, G135, G150, dia5, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1532" promotor_-10 complement(3474291..3474310) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3474302) /Source="Nicolas_upshifts" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3474324..3474331) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3474346..3475683 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /EC_number="1.2.1.3" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391865.2" /db_xref="EnsemblGenomes-Gn:BSU39860" /db_xref="EnsemblGenomes-Tr:CAB16022" /db_xref="GOA:P46329" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11355" /db_xref="UniProtKB/Swiss-Prot:P46329" /translation="MEQQVKDDIQRVFQLQKKQQKALRASTAEQRREKLQRFLDSVIA HEEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPDANG ILMYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRD AFDEKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGK SPTIIDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGF MEDDHTPDRSKFTQIVNDRNFNRVKDLFDDAIERGAEVVFGGVFDASDRTISPTVLKN VTPDMKIMQEEIFASILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHT TSGNAAINDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQAAE*" /label="aldX CDS" gene 3474346..3475683 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /label="aldX gene" S_feature complement(3475088..3475688) /Source="Nicolas_S_feature" /locus_tag="new_4094722_4095322_c" /HighExp="T1.30H, T2.30H, T2.0H, T1.0H, T-2.40H, T3.0H, T3.30H, T0.0H, T-0.40H, T-3.40H" /AntisenseName="aldX" /AntisenseCor="-0.39894728806999702" /AntisenseRegPval="-11" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1533" CDS complement(3475722..3476201) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391866.2" /db_xref="EnsemblGenomes-Gn:BSU39870" /db_xref="EnsemblGenomes-Tr:CAB16023" /db_xref="GOA:P46328" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11354" /db_xref="UniProtKB/Swiss-Prot:P46328" /translation="MNIIPTCQVPKDLVSAFFQKHWGSPQMVISSGIYNCDELDGYGM LNDDNQIVGLITYIFEEDACEIISLDSVIENKGIGTALLEKAEEACRERNIKQIKLIT TNDNIHALAFYQKRGYRLDRLFVNAVETARKMKPEIPLLADNKIPIRDELLLVKELQ* " /label="yxbD CDS" gene complement(3475722..3476201) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /label="yxbD gene" downshifts complement(3475733) /Source="Nicolas_upshifts" /id="D2061" /incds=0 /nref=1 /ntot=39 /MaxReadThrough="3.82941" /MaxDrop="2.52984" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3476281..3477273) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391867.1" /db_xref="EnsemblGenomes-Gn:BSU39880" /db_xref="EnsemblGenomes-Tr:CAB16024" /db_xref="GOA:P46327" /db_xref="InterPro:IPR003347" /db_xref="PDB:1VRB" /db_xref="SubtiList:BG11353" /db_xref="UniProtKB/Swiss-Prot:P46327" /translation="MSAVTESVLESIISPVTMSEFLEEYWPVKPLVARGEVERFTSIP GFEKVRTLENVLAIYNNPVMVVGDAVIEESEGITDRFLVSPAEALEWYEKGAALEFDF TDLFIPQVRRWIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEK TWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLPDAEIVNLTPGTMLYL PRGLWHSTKSDQATLALNITFGQPAWLDLMLAALRKKLISDNRFRELAVNHQSLHESS KSELNGYLESLIQTLSENAETLTPEQIFQSQDSDFDPYQSTQLVFRQLLTSYKF*" /label="yxbC CDS" gene complement(3476281..3477273) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /label="yxbC gene" downshifts complement(3476305) /Source="Nicolas_upshifts" /id="D2062" /incds=0 /nref=5 /ntot=98 /MaxReadThrough="5.86537" /MaxDrop="5.28716" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-1188" /isTUend="FALSE" /label="downshifts" downshifts 3477263 /Source="Nicolas_upshifts" /id="D2063" /incds=0 /nref=2 /ntot=56 /MaxReadThrough="1.15059" /MaxDrop="3.74519" /score="9.93493822" /energy="-12.4" /TU="NA" /idTUdmin="U3134" /TUdmin=4026 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3477296..3477315) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3477314) /Source="Nicolas_upshifts" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3477330..3477337) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3477336..3477343 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3477357..3477781 /Source="Nicolas_S_feature" /locus_tag="new_4096991_4097415" /HighExp="T2.0H, T5.0H, M9-stat, T3.0H, T1.30H, T1.0H, T3.30H, T2.30H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998942" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1534" upshifts 3477357 /Source="Nicolas_upshifts" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3477358..3477377 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 3477363..3477775 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /product="putative small RNA or mRNA leader sequence" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="srlX RNA" gene 3477363..3477775 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /label="srlX gene" upshifts complement(3477383) /Source="Nicolas_upshifts" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3477393..3477407) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3477415..3477419) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3477747 /Source="Nicolas_upshifts" /id="D2064" /incds=0 /nref=2 /ntot=9 /MaxReadThrough="8.39077" /MaxDrop="5.02548" /score="9.93493822" /energy="-12.4" /TU="U3137" /idTUdmin="U3134" /TUdmin=4510 /isTUend="FALSE" /label="downshifts" CDS 3477782..3478516 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /EC_number="2.1.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941984, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_391868.1" /db_xref="EnsemblGenomes-Gn:BSU39890" /db_xref="EnsemblGenomes-Tr:CAB16025" /db_xref="GOA:P46326" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11352" /db_xref="UniProtKB/Swiss-Prot:P46326" /translation="MITAEECRTYKEFVDLYQSYLYPLLGARLSRMYSPKNKVIIDMG TGPGYLSIQLAKRTNAHVHAVDINPAMHEIAQEEAKKSGVSSLISFDLEDVHHLSYAD QYADFIVSYSCLHHWEDVVKGLKECYRVLAPGGKIVILDTFNPQGSHLEIMRKQIKEP EYFRFVREAFEESYSFEDIHQFVQDAGIPNYSLETFHFLPEDFIESLDELEDAPLWEQ NDQSTDHEIESVTWMLTIEKEKEGAL*" /label="yxbB CDS" gene 3477782..3478516 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /label="yxbB gene" CDS 3478516..3478785 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17083466" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391869.1" /db_xref="EnsemblGenomes-Gn:BSU39900" /db_xref="EnsemblGenomes-Tr:CAB16026" /db_xref="InterPro:IPR008792" /db_xref="SubtiList:BG11351" /db_xref="UniProtKB/Swiss-Prot:P46325" /translation="MINESTVLSKNPEMPSRKYLKSIIIEPGITLNEMASDIYNHIDG KVSIHDICSKIVNEYDVDYQTCLEDCMELFELLIDHEAIKVKQGA*" /label="yxbA CDS" gene 3478516..3478785 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /label="yxbA gene" CDS 3478789..3479271 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20185509" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391870.1" /db_xref="EnsemblGenomes-Gn:BSU39910" /db_xref="EnsemblGenomes-Tr:CAB16027" /db_xref="SubtiList:BG14166" /db_xref="UniProtKB/Swiss-Prot:O34704" /translation="MEKQKVLALPDDVHELSTHRSKSIVNYIITLLAFAKKQGLTHQD IVSWIHEQYEERGYYDEWRHINSQQPVGSFVELFIKGRRLLYDKIELFETEDKYVVNT HTWYEKEPSEAFFYFEIDPEEFSAYASILAIENAKRLGIKIDIVKETDVETAYIYKHQ *" /label="yxnB CDS" gene 3478789..3479271 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /label="yxnB gene" CDS 3479292..3481535 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /EC_number="6.3.5.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 17083466, 20185509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 17083466, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (glutamine-hydrolyzing)" /protein_id="NP_391871.2" /db_xref="EnsemblGenomes-Gn:BSU39920" /db_xref="EnsemblGenomes-Tr:CAB16028" /db_xref="GOA:P42113" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11116" /db_xref="UniProtKB/Swiss-Prot:P42113" /translation="MCGLAGIINLAAPRSQECTFHILKGMADAISYRGPDDEQYHIDS KVGFAFRRLSILDLVNGQQPFLNEDGSIVVMVNGEIYNYKELKASLHNHMFKTTSDCE VIVHLYEEKGIGFVDDIIGMFSIAIWDKNKNKVFLVRDRFGIKPLFYTELKHELIFAS EIKSLFSHPHCPRQFNWKEALSDIWLSGEAASNHKETTSFFVNIQNLDAGHYLEINLT TNERKTASYWSLQDILLRQGYRENLHPDDLIEGYRELLADSVHRCLQSDVEVGLFLSG GIDSAAVAHFAAEKQDLHTFTVLSQSTFTNEDAKYAHWLAKDLHLPNHQVLYQLGNDE LLQPESYKHLLWICETPFCGPEQLYKFHLHKYAKAIRPNLKVMLTGQGSDEFNGGYST TLSPAENPSWEGFIESVNTMEMNRLHRLQGNIFRVWEEHFGLSPINLSYLKSNDSSQA DPWQSYVLTKYRDLQMYNCWHEDRIAAANHIENRVPFLDHRLVEWVCGIPDGLRKDLL WDKSVLRKSLTNELHTSYTHRPKVPFFYGKDVRYTHKMMFHLLKKNNYQLIEEAFSHS DASSIIQVEHIHAIMTYLEDDPEFTNFEFLLRLVNMGLLSKMTKETPSVQLDITSHLE SITIKDWHSQEGDIASRLNISANKCEGQDILALNPGVTLLRPESDSEHCIYIAEEGFI QFIVSEEDVGAWLHILCDINGKDTLHTILDRHGVSLEEVAKYIQEAIEHNIILIKQKN LPEGAYR*" /label="asnH CDS" gene 3479292..3481535 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /label="asnH gene" CDS 3481532..3482731 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989, 15849754, 16850406, 20185509; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391872.2" /db_xref="EnsemblGenomes-Gn:BSU39930" /db_xref="EnsemblGenomes-Tr:CAB16029" /db_xref="GOA:P42112" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11115" /db_xref="UniProtKB/Swiss-Prot:P42112" /translation="MSIFYSFSALRGLAMGIFSPIWILYLISKDYDFLQIGLMGAVLE IAKLIFEVPSGVFADRYGIKISIASSFFFSILTWAFFPFIDSAAICILAMIIWALSDS LISGSFETWMSRVAGEDRFGKEMMKNTQLLITFLIIGSIASGYLYSLNIYFPFLLVMV IYLLLFIWMSVFIKVPSVSETNHGDQNQHDSIKIIKESLKIIFNKKRVLLIVIAGFFT ATAYDTISRYWQPFLSDLGFSEKSLGYIFALGGFTALVLLTLTIRFEKKIEKNPYLAL TSLDSMGMVMTFLLSRAFRPLGIPCTAFLLAIEDIHHPIVTSYLNKFFPDSYKNTLFS LNSGVGAIGEILSGVIFGIISAAFGLSAMFVVVAVFLLIPIILYTIVPKIKDNDMKVQ IEKSQQV*" /label="yxaM CDS" gene 3481532..3482731 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /label="yxaM gene" promotor_-10 complement(3482487..3482505) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3482509) /Source="Nicolas_upshifts" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3482520..3482526) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3482722 /Source="Nicolas_upshifts" /id="D2065" /incds=0 /nref=71 /ntot=174 /MaxReadThrough="3.22879" /MaxDrop="5.42242" /score="-6.94914943" /energy="-8.5" /TU="U3137" /idTUdmin="U3137" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts complement(3482795) /Source="Nicolas_upshifts" /id="D2066" /incds=0 /nref=156 /ntot=227 /MaxReadThrough="3.53794" /MaxDrop="6.77896" /score="7.32872401" /energy="-16.9" /TU="U3140" /idTUdmin="U3141" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3482795..3484027) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 15743949, 17060472, 18165306, 22720735, 26060272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane associated protein kinase with beta-propeller domain" /protein_id="NP_391873.2" /db_xref="EnsemblGenomes-Gn:BSU39940" /db_xref="EnsemblGenomes-Tr:CAB16030" /db_xref="GOA:P42111" /db_xref="InterPro:IPR002372" /db_xref="InterPro:IPR011047" /db_xref="InterPro:IPR018391" /db_xref="SubtiList:BG11114" /db_xref="UniProtKB/Swiss-Prot:P42111" /translation="MVKSFRMKALIAGAAVAAAVSAGAVSDVPAAKVLQPTAAYAAET VFSQNNGASGFLPGRYDVQAMAPAMFNWSRESRFAGNTDGTLKWQNDIRTTPQNGAGA VIDGDGTVYLHSRDGEMKAFNPDGSVKWVTGNLGKTYTQSPVLGTNGVIYLASYDKKI YFIDKETGEILTTVPLSGGPSSETVIGSDGTLYFSTLDNYVHAIKPTSKSTWTERWKL KTNGVVSSVPVLAKNGTVYVGTYNYVFYAINSGTGQVKWSRTTSNAFKGYPVIDKDGN IYAGNQDGQLYAYTSTGSLKWTFPLNGFSSSSPAIDHNGNIYIGSGSGELFSISKNGD MNWSFYTDGPVRTAPLIDAKGTVYFGSDDMKVYAADANGNELWSYQTDSNVVSSPQLA EDGTLYIGSYTKLMAFGK*" /label="yxaL CDS" gene complement(3482795..3484027) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /label="yxaL gene" promotor_-10 complement(3484059..3484078) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3484071) /Source="Nicolas_upshifts" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3484092..3484097) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3484128..3484553) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949, 15849754, 16850406, 27902860; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391875.2" /db_xref="EnsemblGenomes-Gn:BSU39950" /db_xref="EnsemblGenomes-Tr:CAB16032" /db_xref="GOA:P42109" /db_xref="InterPro:IPR020204" /db_xref="SubtiList:BG11112" /db_xref="UniProtKB/Swiss-Prot:P42109" /translation="MSKKNSVAIMTTISAFLFCAVIVAASLSPLAGTGAAANQFNSAG MWSAVGMILVLYFIPFLVYMLGVDAMRYVMAVLCGFGLLIHLSSAGFILMFSFFSDHL LSEVIFVLGVSLAAAAVNVIWFVAAFRSGAEKTSVNTLT*" /label="yxaJ CDS" gene complement(3484128..3484553) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /label="yxaJ gene" promotor_-10 complement(3484581..3484600) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3484595) /Source="Nicolas_upshifts" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3484613..3484619) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3484745..3484752 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3484762 /Source="Nicolas_upshifts" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3484767..3484786 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3484810..3485265 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391876.1" /db_xref="EnsemblGenomes-Gn:BSU39960" /db_xref="EnsemblGenomes-Tr:CAB16033" /db_xref="GOA:P42108" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11111" /db_xref="UniProtKB/Swiss-Prot:P42108" /translation="MEKPAGFWIRFLAYFIDGIIVSVPSYIILFIINSVFVAGAVATN PYMTEEEYLVKYMTLAFLPTMLIMIVISVLYYGLLTASKMQGTLGKKILGLKVVNEQG ERVSVGQGIGRYFAYILSGIIFYIGFIMIAFGEKKGLHDIICKTRVVYK*" /label="yxaI CDS" gene 3484810..3485265 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /label="yxaI gene" downshifts 3485203 /Source="Nicolas_upshifts" /id="D2067" /incds=1 /nref=58 /ntot=234 /MaxReadThrough="3.24719" /MaxDrop="5.4441" /score="18.1083522" /energy="-13.4" /TU="U3142" /idTUdmin="U3142" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" S_feature 3485266..3485879 /Source="Nicolas_S_feature" /locus_tag="new_4104900_4105513" /HighExp="LPh, HPh, MG 60, BMM, MG t5, G180, MG 45, G150, MG-0.2, MG 10" /AntisenseName="yxaH" /AntisenseCor="0.37646026982403002" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1535" CDS complement(3485295..3486503) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein involved in response to flavonoids" /protein_id="NP_391877.2" /db_xref="EnsemblGenomes-Gn:BSU39970" /db_xref="EnsemblGenomes-Tr:CAB16034" /db_xref="GOA:P42107" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11110" /db_xref="UniProtKB/Swiss-Prot:P42107" /translation="MSSLQPTLTNERIGVLDVLRGMAIFGILFVNLAHFSYPDMYLSM LGKENFFMDKWSEADFAAADILKFFIQTKCILLFSFLFGFGMVVMMERAENKGKRFVP LYVRRLMALLLFGTIHAFLIWDGDILTEYALLGFVLLLFRKAKPKTLLIWAVSLYLLF SIPFMLTSFDQSNGQEWVQAVTQQAKQAIHVYGSGSLKDIAEQRIHDRLVYMSSNGML TYNPLNYFFASIPYFSMFLLGAAAAKSRYLHEPEKHRKGLKRLWMAGLVIGIGAQVLY SVTDKEICLLIGAPFLMFFYVTTVVYLYHKTRVRTVLQSFSAVGRMAFTNYLMQSIVC TWIFYHYGLGLYGKVYPAAGVLITIAVCAVQMVFSHLWLRVFRMGPFEWLWRSATYLS WQPIAKKTKV*" /label="yxaH CDS" gene complement(3485295..3486503) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /label="yxaH gene" downshifts complement(3485322) /Source="Nicolas_upshifts" /id="D2068" /incds=0 /nref=14 /ntot=66 /MaxReadThrough="0.30987" /MaxDrop="3.782" /score="34.1593124" /energy="-16.2" /TU="NA" /idTUdmin="U3143" /TUdmin=286 /isTUend="FALSE" /label="downshifts" S_feature complement(3486504..3486610) /Source="Nicolas_S_feature" /locus_tag="new_4106138_4106244_c" /HighExp="T-5.40H, T-4.40H, SMMPr, T-2.40H, T-3.40H, T-1.40H, Sw, T0.0H, Pyr, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1536" CDS complement(3486611..3487624) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /EC_number="1.13.11.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quercetin dioxygenase" /protein_id="NP_391878.2" /db_xref="EnsemblGenomes-Gn:BSU39980" /db_xref="EnsemblGenomes-Tr:CAB16035" /db_xref="GOA:P42106" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:1Y3T" /db_xref="PDB:2H0V" /db_xref="SubtiList:BG11109" /db_xref="UniProtKB/Swiss-Prot:P42106" /translation="MKTLCTHSLPKEKMPYLLRSGEGERYLFGRQVATVMANGRSTGD LFEIVLLSGGKGDAFPLHVHKDTHEGILVLDGKLELTLDGERYLLISGDYANIPAGTP HSYRMQSHRTRLVSYTMKGNVAHLYSVIGNPYDHAEHPPYASEEVSNERFAEAAAVAD IVFLDEAKPACSAKLAELTELPDGAVPYVLESGEGDRLLTGDQLHRIVAAQKNTDGQF IVVSSEGPKGDRIVDHYHEYHTETFYCLEGQMTMWTDGQEIQLNPGDFLHVPANTVHS YRLDSHYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCEPQALRFDRILQNIEALDLKV MKP*" /label="qdoI CDS" gene complement(3486611..3487624) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /label="qdoI gene" S_feature complement(3487625..3487698) /Source="Nicolas_S_feature" /locus_tag="new_4107259_4107332_c" /HighExp="T-3.40H, T-5.40H, T-1.40H, T-2.40H, T-4.40H, T-0.40H, T0.0H, Pyr, SMMPr, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1537" promotor_-10 complement(3487683..3487702) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3487698) /Source="Nicolas_upshifts" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3487715..3487722) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3487718..3488293) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17483215, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483215, 21737930; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of qdoI" /protein_id="NP_391879.2" /db_xref="EnsemblGenomes-Gn:BSU39990" /db_xref="EnsemblGenomes-Tr:CAB16036" /db_xref="GOA:P42105" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1SGM" /db_xref="SubtiList:BG11108" /db_xref="UniProtKB/Swiss-Prot:P42105" /translation="MTSRGDSREKILHTASRLFQLQGYHATGLNQIVKESGAPKGSLY HFFPNGKEELAIEAVTYTGKIVEHLIQQSMDESSDPVEAIQLFIKKTASQFDNTESIK GIPVGLLASETALISEPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMI EGGIMLSLTNKDKTPLLLIAEQIPVLVRKKG*" /label="qdoR CDS" gene complement(3487718..3488293) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /label="qdoR gene" downshifts complement(3487742) /Source="Nicolas_upshifts" /id="D2069" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="1.66581" /MaxDrop="2.62803" /score="-2.51956315" /energy="-8.8" /TU="NA" /idTUdmin="U3144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3488322..3488341) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3488336) /Source="Nicolas_upshifts" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3488356..3488363) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3488364..3488370 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3488385..3488403 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3488392 /Source="Nicolas_upshifts" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="upshifts" CDS 3488424..3489494 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391880.2" /db_xref="EnsemblGenomes-Gn:BSU40000" /db_xref="EnsemblGenomes-Tr:CAB16037" /db_xref="GOA:O32291" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14165" /db_xref="UniProtKB/Swiss-Prot:O32291" /translation="MTIDHSVTNTEQLEQQNPAIKTKLKLKKLKDQVIVITGASSGIG LVTARMAAEKGAKVVAAARNEEALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETA ISTFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVP GALINVGSLFGDRGTVIQSTYASAKFALHGWTESIRMELEKEQAPVSVTLIHPGRIDT PYNEHAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALF PRLTDRLMEKIMYHSQHAERPSNPREESALYDAGCGMHDRGTNKGWMRSRSYYTKATK RPIVSAAVVAGLVAWAAAKRCR*" /label="yxnA CDS" gene 3488424..3489494 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /label="yxnA gene" downshifts 3489492 /Source="Nicolas_upshifts" /id="D2070" /incds=0 /nref=7 /ntot=44 /MaxReadThrough="2.68466" /MaxDrop="3.96227" /score="-3.48213422" /energy="-11.2" /TU="NA" /idTUdmin="U3145" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3489551..3489982) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391881.1" /db_xref="EnsemblGenomes-Gn:BSU40010" /db_xref="EnsemblGenomes-Tr:CAB16038" /db_xref="GOA:P42103" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11106" /db_xref="UniProtKB/Swiss-Prot:P42103" /translation="MQNQNPVELIEYELTTFIRRAVYLDQSEKRTGNLERSSYLLLRQ LDEFGPARVKELAESFKLDISTLSRQAAALEAKELIYRFSDPSDGRVSLFTITKLGKQ LLKADQQKRLERYEQMLKEWSTQEKEMFGELLQRMNKAFID*" /label="yxaD CDS" gene complement(3489551..3489982) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /label="yxaD gene" promotor_-35 3490012..3490019 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3490033..3490052 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3490042..3490208 /Source="Nicolas_S_feature" /locus_tag="new_4109676_4109842" /HighExp="LBGstat, Cold, Heat, Salt, Etha, H2O2, G180, LBGtran, GM 150, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1538" upshifts 3490042 /Source="Nicolas_upshifts" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3490094..3490113) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3490114) /Source="Nicolas_upshifts" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3490128..3490135) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3490209..3490613 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein involved in export murein hydrolases" /protein_id="YP_003097798.1" /db_xref="EnsemblGenomes-Gn:BSU40021" /db_xref="EnsemblGenomes-Tr:CAX52713" /db_xref="GOA:C0H3T7" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR036640" /db_xref="UniProtKB/Swiss-Prot:C0H3T7" /translation="MKVIRIILQVLILYVFFMIGEAIQHLFHLPVSGSIVGLVLLLIC LGLRIVPVSIIEDGAGFLLSFLPLLFIPAMTGVINYPSLISFNGLMLLITVVLSTIVT IIAAGFASQLLEKKAKKREEKEKCSKHVSRSL*" /label="yxzK CDS" gene 3490209..3490613 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /label="yxzK gene" S_feature complement(3490230..3491282) /Source="Nicolas_S_feature" /locus_tag="new_4109864_4110916_c" /HighExp="Etha, C30, H2O2, Salt, Paraq, GM 120, Diami, Oxctl, G180, Sw" /AntisenseName="yxaC" /AntisenseCor="0.145103505386703" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1539" CDS 3490583..3491275 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative murein hydrolase export regulator" /protein_id="NP_391882.3" /db_xref="EnsemblGenomes-Gn:BSU40022" /db_xref="EnsemblGenomes-Tr:CAB16039" /db_xref="GOA:P42102" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG11105" /db_xref="UniProtKB/Swiss-Prot:P42102" /translation="MQQACIAIIIILLTVAAYLAMVKLYKRFPLPFLIPVLTTTILIV AALMMFHVSYEGYMIGGKWINSLLGPAVVALAYPLYKQWHIIVKHCVPILGGVLVGLC MGMISGLIFAEAFGIDHDLLLSILPKSITTPVAIQIAAGLGGVPSMTVVFVMIAGFSG VILGPLFLKWLRIRSSLGQGIALGSASHALGTSKALEYGELAVSMSSVSMTLCAVLGS FFGPLVVWLFHI*" /label="yxaC CDS" gene 3490583..3491275 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /label="yxaC gene" CDS complement(3491315..3492346) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /EC_number="2.-.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9298659, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exopolysaccharide pyruvyl transferase (biofilm formation)" /protein_id="NP_391883.3" /db_xref="EnsemblGenomes-Gn:BSU40030" /db_xref="EnsemblGenomes-Tr:CAB16040" /db_xref="GOA:P42101" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11104" /db_xref="UniProtKB/Swiss-Prot:P42101" /translation="MTVQEIKGKKLVKGIAPNVEPEALLNDKRKVFLFGSPSYTNIGD QAIAYAEEKFIKNHFPYYEYIEIMDYATDEGIELVKEIIREDDIVCFTGGGNLGNLYL DIEEDRRKVFSAFKDYKSISLPQSVYFEDTEEGQKEKKKTQDAYHQNTNLTIAARETQ TLDVVKETFNSNVIFTPDMVLSLDIVPRELERDGVLFILRADKEKVTDEDFISQMKQW AEKTTYTERTDTVLDTVDTIDYADREKHFMEMLDRIGSSKLVITDRLHAMIFSIITKT PCLVFGNSYGKAKHSYRDWLESLNFIEYTDKNDVEELERMIDRLLQAEPNDVDLSKDF QPLIDFFAS*" /label="yxaB CDS" gene complement(3491315..3492346) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /label="yxaB gene" downshifts complement(3491327) /Source="Nicolas_upshifts" /id="D2071" /incds=0 /nref=5 /ntot=94 /MaxReadThrough="6.52386" /MaxDrop="4.6522" /score="17.8326496" /energy="-15.3" /TU="U3149" /idTUdmin="U3150" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-35 3492313..3492316 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3492329 /Source="Nicolas_upshifts" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3492333..3492352 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3492383..3492401) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3492401) /Source="Nicolas_upshifts" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3492416..3492422) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3492439..3493587) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /EC_number="2.7.1.31" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15771780, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-glycerate kinase" /protein_id="NP_391884.2" /db_xref="EnsemblGenomes-Gn:BSU40040" /db_xref="EnsemblGenomes-Tr:CAB16041" /db_xref="GOA:P42100" /db_xref="InterPro:IPR004381" /db_xref="InterPro:IPR018193" /db_xref="InterPro:IPR036129" /db_xref="SubtiList:BG11103" /db_xref="UniProtKB/Swiss-Prot:P42100" /translation="MKIIIAPDSFKESLSALEAAEAIERGFKSVFPGADYRKLPVADG GEGTVQSLVDATNGRIIEQVVTGPLGEPVRAFFGMMGDGRTAVIEMAAASGLHLVPVD KRNPLITTTRGTGELIGAALDAGAERLIIGIGGSATNDGGAGMIQALGGRLLDNSGSE IGPGGGALSQLASIDVSGLDSRLRNVKLEVACDVDNPLTGPKGATAVFGPQKGATADM LDVLDQNVSHFADMAEKALGSTFRDTEGAGAAGGLGWSLLTYLQADLKRGIDIVLEAV DFESIVQDADLVITGEGRIDSQTVHGKTPIGVAKAAKSYDVPVIGIAGSISRDSNAVY QHGIDALFSIVPGAVPLEDAFEHAAEYMERTARDIAASIKLAKTMFLI*" /label="glxK CDS" gene complement(3492439..3493587) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /label="glxK gene" promotor_-10 complement(3493626..3493645) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3493637) /Source="Nicolas_upshifts" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3493656..3493663) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3493709..3493716 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3493730..3493749 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3493737 /Source="Nicolas_upshifts" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3493783..3494514 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7476858, 7642511, 8655507, 9106211, 26151451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7476858, 7642511, 8655507, 9106211, 26151451; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR-gluconate)" /protein_id="NP_391885.1" /db_xref="EnsemblGenomes-Gn:BSU40050" /db_xref="EnsemblGenomes-Tr:CAB16042" /db_xref="GOA:P10585" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10648" /db_xref="UniProtKB/Swiss-Prot:P10585" /translation="MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSE NTIAAEFSVSRSPVREALKILASEKIIRLERMGAVVIGLTEKKIAEIYDVRLLLETFV FERLVKIDIEPLVKDLSKILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMI WNNLKPVMESFILLSMRVRLKEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFD DVQDKVEDLWLSQQMLAKGAEYNND*" /label="gntR CDS" gene 3493783..3494514 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /label="gntR gene" CDS 3494507..3496048 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /EC_number="2.7.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1659648, 2537826, 3020045, 11468405" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1659648, 2537826, 3020045, 11468405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-gluconate kinase" /protein_id="NP_391886.1" /db_xref="EnsemblGenomes-Gn:BSU40060" /db_xref="EnsemblGenomes-Tr:CAB16043" /db_xref="GOA:P12011" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006002" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10649" /db_xref="UniProtKB/Swiss-Prot:P12011" /translation="MTSYMLGIDIGTTSTKAVLFSENGDVVQKESIGYPLYTPDISTA EQNPEEIFQAVIHTTARITKQHPEKRISFISFSSAMHSVIAIDENDKPLTPCITWADN RSEGWAHKIKEELNGHEVYKRTGTPIHPMAPLSKIAWITNERKEIASKAKKYIGIKEY IFKQLFNEYVIDYSLASATGMMNLKGLDWDEEALRIAGITPDHLSKLVPTTEIFQHCS PEIAIQMGIDPETPFVIGASDGVLSNLGVNAIKKGEIAVTIGTSGAIRTIIDKPQTDE KGRIFCYALTDKHWVIGGPVNNGGIVLRWIRDEFASSEIETATRLGIDPYDVLTKIAQ RVRPGSDGLLFHPYLAGERAPLWNPDVRGSFFGLTMSHKKEHMIRAALEGVIYNLYTV FLALTECMDGPVTRIQATGGFARSEVWRQMMSDIFESEVVVPESYESSCLGACILGLY ATGKIDSFDAVSDMIGSTYRHTPIEDSAKEYRTLMPIFINLSRLLENQYTQIADYQRG LITHK*" /label="gntK CDS" gene 3494507..3496048 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /label="gntK gene" CDS 3496077..3497423 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3020045, 15849754, 1659648, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3020045, 15849754, 1659648, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gluconate/proton permease" /protein_id="NP_391887.1" /db_xref="EnsemblGenomes-Gn:BSU40070" /db_xref="EnsemblGenomes-Tr:CAB16044" /db_xref="GOA:P12012" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG10650" /db_xref="UniProtKB/Swiss-Prot:P12012" /translation="MPLIIVALGILALLFLIMGLKLNTFISLLVVSFGVALALGMPFD KVVSSIEAGIGGTLGHIALIFGLGAMLGKLIADSGGAQRIAMTLVNKFGEKNIQWAVV IASFIIGIALFFEVGLVLLIPIVFAISRELKISILFLGIPMVAALSVTHGFLPPHPGP TAIAGEYGANIGEVLLYGFIVAVPTVLIAGPLFTKFAKKIVPASFAKNGNIASLGTQK TFNLEETPGFGISVFTAMLPIIIMSVATIIDLLQETIGFADNGVLAFIRLIGNASTAM IISLLVAVYTMGIKRNIPVKTVMDSCSTAISQIGMMLLIIGGGGAFKQVLINGGVGDY VADLFKGTALSPIILAWLIAAILRISLGSATVAALSTTGLVIPLLGHSDVNLALVVLA TGAGSVIASHVNDAGFWMFKEYFGLSMKETFATWTLLETIISVAGLGFILLLSLVV*" /label="gntP CDS" gene 3496077..3497423 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /label="gntP gene" promotor_-35 3496876..3496880 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3496896..3496915 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3496905 /Source="Nicolas_upshifts" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3497446..3498852 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /EC_number="1.1.1.343" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 9535092, 9931298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 9535092, 9931298; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconate dehydrogenase (NAD+-dependent)" /protein_id="NP_391888.1" /db_xref="EnsemblGenomes-Gn:BSU40080" /db_xref="EnsemblGenomes-Tr:CAB16045" /db_xref="GOA:P12013" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10651" /db_xref="UniProtKB/Swiss-Prot:P12013" /translation="MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQK LDGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNS HYEDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAA QVGDDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFE TWNQGELKSYLIEITAEILRKKDEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPS TIITESLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEYVRQALYMGKVCAYA QGFAQYKMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPY FTDKLHAYQTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGA HTYERTDMDGVFHTNWSE*" /label="gntZ CDS" gene 3497446..3498852 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /label="gntZ gene" downshifts 3498841 /Source="Nicolas_upshifts" /id="D2072" /incds=0 /nref=128 /ntot=228 /MaxReadThrough="3.81668" /MaxDrop="5.52642" /score="20.2280166" /energy="-10.2" /TU="NA" /idTUdmin="U3151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 3498949..3498968 /Source="Nicolas_upshift_promotors" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3498951..3499242 /Source="Nicolas_S_feature" /locus_tag="new_4118585_4118876" /HighExp="S8, Etha, Sw, T0.30H, Cold, H2O2, B60, S5, S4, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1540" upshifts 3498951 /Source="Nicolas_upshifts" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="upshifts" promotor_-35 3499215..3499222 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3499237..3499256 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3499244 /Source="Nicolas_upshifts" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3499266..3499273 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3499288..3499307 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3499291) /Source="Nicolas_upshifts" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3499294..3499308) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3499303 /Source="Nicolas_upshifts" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3499316..3499320) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3499316..3499879 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /EC_number="1.11.1.5" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932315, 14766928, 26322180" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932315, 14766928, 26322180; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (small subunit)" /protein_id="NP_391889.1" /db_xref="EnsemblGenomes-Gn:BSU40090" /db_xref="EnsemblGenomes-Tr:CAB16046" /db_xref="GOA:P80239" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017559" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11385" /db_xref="UniProtKB/Swiss-Prot:P80239" /translation="MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFS FVCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHKGWHDSSEKISKITYAMIGDPSQ TISRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQ NPGEVCPAKWEEGGETLTPSLDLVGKI*" /label="ahpC CDS" gene 3499316..3499879 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /label="ahpC gene" CDS 3499893..3501422 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /EC_number="1.6.99.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932314, 14766928, 16232966, 23899494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932314, 14766928, 16232966, 23899494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (large subunit)" /protein_id="NP_391890.1" /db_xref="EnsemblGenomes-Gn:BSU40100" /db_xref="EnsemblGenomes-Tr:CAB16047" /db_xref="GOA:P42974" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR012081" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11204" /db_xref="UniProtKB/Swiss-Prot:P42974" /translation="MVLDANIKAQLNQYMQLIENDIVLKVSAGEDDTSKDMLALVDEL ASMSSKISVEKAELNRTPSFSVNRVGEDTGVTFAGIPLGHEFTSLVLALLQVSGRPPK VDQKVIDQVKKISGEYHFESYISLTCHNCPDVVQALNMMSVLNPNITHTMIDGAAYKA EVESKNIMAVPTVYLNGESFGSGRMTLEEILAKMGSGTDASEFADKEPFDVLVVGGGP AGASAAIYTARKGIRTGVVAERFGGQVLDTMSIENFISVKATEGPKLAASLEEHVKEY DIDVMNLQRAKRLEKKDLFELELENGAVLKSKTVILSTGARWRNVNVPGEQEFKNKGV AYCPHCDGPLFEGKDVAVIGGGNSGIEAAIDLAGIVNHVTVLEFAPELKADEVLQKRL YSLPNVTVVKNAQTKEITGDQSVNGITYVDRETGEEKHVELQGVFVQIGLVPNTEWLE GTVERNRMGEIIVDKHGATSVPGLFAAGDCTDSAYNQIIISMGSGATAALGAFDYLIR N*" /label="ahpF CDS" gene 3499893..3501422 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /label="ahpF gene" downshifts complement(3501249) /Source="Nicolas_upshifts" /id="D2073" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="3.25325" /MaxDrop="3.69049" /score="1.76901559" /energy="-18" /TU="NA" /idTUdmin="U3157" /TUdmin=198 /isTUend="FALSE" /label="downshifts" downshifts 3501415 /Source="Nicolas_upshifts" /id="D2074" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="3.92009" /MaxDrop="8.88048" /score="33.1934883" /energy="-19.6" /TU="U3154" /idTUdmin="U3156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3501448..3501531) /Source="Nicolas_S_feature" /locus_tag="new_4121082_4121165_c" /HighExp="G150, C30, LPhT, G135, S8, LBGstat, T0.30H, G180, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1541" downshifts complement(3501491) /Source="Nicolas_upshifts" /id="D2075" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.37922" /MaxDrop="4.44094" /score="1.76901559" /energy="-18" /TU="U3157" /idTUdmin="U3157" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3501532..3502971) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8125345, 14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8125345, 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-6-phospho-beta-glucosidase" /protein_id="NP_391891.1" /db_xref="EnsemblGenomes-Gn:BSU40110" /db_xref="EnsemblGenomes-Tr:CAB16048" /db_xref="GOA:P42973" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11203" /db_xref="UniProtKB/Swiss-Prot:P42973" /translation="MGNMPKDFLWGGALAAHQFEGGWNQGGKGPSVVDVMTAGAHGVP RKITDTIEENEFYPNHEAIDFYHRYKEDIALFAEMGLKCLRTSIGWSRIFPKGDEAEP NEAGLQFYDDVFDELLKHGIEPVITLSHFEMPLHLAREYGGFRNRKVVDFFVNFAEAC FTRYKDKVKYWMTFNEINNQMDVNNPLFLWTNSGVVVGENENAKEVMYQTAHHELVAS ALAVAKGKDINPEFQIGAMVSHVPIYPFSSNPEDVMLAEEEMRQRYFFPDVQVRGYYP SYALKEFEREGYNITFEDGDDEILRNGTVDYLGFSYYMSTTVKSDVKNDNTGDIVNGG LPNGVENPYITSSDWGWAIDPTGLRYTLNRFYDRYQIPLFIVENGFGAVDTLEEDGKV HDPERIQYLKSHIEALKKAVTYDGVDLIGYTPWGIIDIVSFTTGEMKKRYGMIYVDRD NEGNGSMKRYKKDSFEWYKNVIQTNGEEL*" /label="bglA CDS" gene complement(3501532..3502971) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /label="bglA gene" CDS complement(3502985..3503215) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /EC_number="2.7.1.-" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867744, 28731580" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867744, 28731580; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucose phosphotransferase system enzyme IIA component" /protein_id="NP_391892.1" /db_xref="EnsemblGenomes-Gn:BSU40120" /db_xref="EnsemblGenomes-Tr:CAB16049" /db_xref="GOA:O32292" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG14172" /db_xref="UniProtKB/Swiss-Prot:O32292" /translation="MVTPTKHAIGLRSASGVELLAHIGLDTVTFDGTPFSLKVKEGDT VKKGEVLVEFDKAFIEDIEESALHQKIFTVVS*" /label="ptsJ CDS" gene complement(3502985..3503215) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /label="ptsJ gene" S_feature complement(3503216..3503427) /Source="Nicolas_S_feature" /locus_tag="new_4122850_4123061_c" /HighExp="G150, LPhT, T0.30H, Diami, G135, LBGstat, G180, Oxctl, Lbexp, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1542" promotor_-10 complement(3503424..3503443) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3503429) /Source="Nicolas_upshifts" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3503458..3503465) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3503491..3503498 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3503509..3503528 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3503524 /Source="Nicolas_upshifts" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="upshifts" CDS 3503559..3504269 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_391893.1" /db_xref="EnsemblGenomes-Gn:BSU40130" /db_xref="EnsemblGenomes-Tr:CAB16050" /db_xref="GOA:Q45591" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3BWG" /db_xref="SubtiList:BG11484" /db_xref="UniProtKB/Swiss-Prot:Q45591" /translation="MLKYQQIATEIETYIEEHQLQQGDKLPVLETLMAQFEVSKSTIT KSLELLEQKGAIFQVRGSGIFVRKHKRKGYISLLSNQGFKKDLEDFNVTSKVIELDVR KPTPEAAENLNIGMDEDIYYVKRVRYINGQTLCYEESYYTKSIVTYLNNEIVSHSIFH YIREGLGLKIGFSDLFLHVGQLNEEEAEYLGLEAGLPKLYIESIFHLTNGQPFDYSKI SYNYEQSQFVVQANSFLL*" /label="yydK CDS" gene 3503559..3504269 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /label="yydK gene" CDS 3504297..3504455 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097799.1" /db_xref="EnsemblGenomes-Gn:BSU40139" /db_xref="EnsemblGenomes-Tr:CAX52714" /db_xref="GOA:C0H3T8" /db_xref="UniProtKB/Swiss-Prot:C0H3T8" /translation="MYKIIIPAILAIFALWILLQISLEMSIVKNPMNYFIVFIIFFLF VKMVKEKQ*" /label="yyzN CDS" gene 3504297..3504455 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /label="yyzN gene" downshifts 3504532 /Source="Nicolas_upshifts" /id="D2076" /incds=0 /nref=16 /ntot=177 /MaxReadThrough="0.96913" /MaxDrop="4.2349" /score="-9.95345673" /energy="-14.7" /TU="NA" /idTUdmin="U3158" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3504586..3505308) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /function="16.1: Circulate" /function="16.3: Control" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="permease for export of regulatory peptide LiaD*" /protein_id="NP_391894.1" /db_xref="EnsemblGenomes-Gn:BSU40140" /db_xref="EnsemblGenomes-Tr:CAB16051" /db_xref="GOA:Q45592" /db_xref="SubtiList:BG11483" /db_xref="UniProtKB/Swiss-Prot:Q45592" /translation="MKLEFKKSISNKVIIILGAMFVFLFLLGYFLLVGIDKVSNVTPE MFFFSSYTVATQFGLMLFSFVIAFFINREYSNKNILFYKLIGENIYTFFYKKIAVLFL ECFAFITLGLLIISLMYHDFSHFALLLFLFSAVILQYILIIGTISVLCPNILISIGVS IVYWMTSVILVAISNKTFGFIAPFEAGNTMYPRIERVLQSDNMTLGSNDVLFIILYLV SIIIINAIVLRFSKTRWIKMGL*" /label="liaM CDS" gene complement(3504586..3505308) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /label="liaM gene" downshifts complement(3504598) /Source="Nicolas_upshifts" /id="D2077" /incds=0 /nref=225 /ntot=267 /MaxReadThrough="2.70741" /MaxDrop="6.21099" /score="7.49162587" /energy="-10.5" /TU="NA" /idTUdmin="U3160" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-35 3505209..3505212 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3505228..3505232 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3505243 /Source="Nicolas_upshifts" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3505329..3505958) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter for regulatory peptide LiaD* (ATP-binding protein)" /protein_id="NP_391895.1" /db_xref="EnsemblGenomes-Gn:BSU40150" /db_xref="EnsemblGenomes-Tr:CAB16052" /db_xref="GOA:Q45593" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11482" /db_xref="UniProtKB/Swiss-Prot:Q45593" /translation="MNIANYTLKVKGKTLLQDTDLHFSSGKINHVVGKNGVGKSQLAK DFLLNNSKRIGRDIRQNVSLISSSSNIPNDVSKDFLLHFLSKKFDAKMIDKIAYLLNL DNIDGKVLIKNLSDGQKQKLKLLSFLLEDKNIIVLDEITNSLDKKTVIEIHGFLNKYI QENPEKIIINITHDLSDLKAIEGDYYIFNHQEIQQYHSVDKLIEVYINE*" /label="liaL CDS" gene complement(3505329..3505958) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /label="liaL gene" S_feature complement(3505959..3506107) /Source="Nicolas_S_feature" /locus_tag="new_4125593_4125741_c" /HighExp="T-0.40H, LoTm, T-2.40H, T0.0H, M9-tran, SMMPr, T-1.40H, GM 150, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1543" CDS complement(3506108..3506866) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease acting on modified factor LiaD" /protein_id="NP_391896.2" /db_xref="EnsemblGenomes-Gn:BSU40160" /db_xref="EnsemblGenomes-Tr:CAB16053" /db_xref="GOA:Q45594" /db_xref="SubtiList:BG11481" /db_xref="UniProtKB/Swiss-Prot:Q45594" /translation="MKILKYEDEKYEVLVQNNVFIKDKKSGEYYKNSLNSLSDKQLLR FKMYKEKVSPKFFYLFLSFTALMFILNYIHLIKLQNGLSSVFYGWKMWIIIVIYFIMN IVLHELGHIYSLKFFGKNFDKVGFKLNFYVFPAFYVQLNETYMLSRNEKIIVHLFGLF INYLLINTLELINQFTFSSEALTMAFMLFSSTLLWNLIPILNSDGYKILLAFLSLDEY SRFKTNHWLVLTIQIIGIGLAVNSVVHWILYIVN*" /label="liaK CDS" gene complement(3506108..3506866) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /label="liaK gene" promotor_-10 complement(3506556..3506575) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3506572) /Source="Nicolas_upshifts" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3506588..3506595) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3506847..3507806) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /EC_number="5.1.1.-" /experiment="publication(s) with functional evidences, PMID:17921301, 18307109, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17921301, 18307109, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="AdoMet radical amino acid epimerase modifying factor LiaD" /protein_id="NP_391897.1" /db_xref="EnsemblGenomes-Gn:BSU40170" /db_xref="EnsemblGenomes-Tr:CAB16054" /db_xref="GOA:Q45595" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR023904" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG11480" /db_xref="UniProtKB/Swiss-Prot:Q45595" /translation="MYNKTVSINLDSRCNASCDHCCFSSSPTSTTRMEKEYIRELVTE FAKNKTIQVISFTGGEVFLDYKFLKELMEIIKPYEKQITLISNGFWGLSKKKVQEYFH DMNSLNVIALTISYDEYHAPFVKSSSIKNILEHSRKYPDIDISLNMAVTKDKMSNHIL EELGDSILGVKITKFPMISVGAAKTRIKQENIHKFYSLEDEDSLHCPGYDIVYHHDGE IYPCCSPAIFETKITLREEYNQSFERTVEKLNSNLLLFILRKEGFKWFLNILKENNKI EEFDIPYEFSSICGVCGSLFNSAEKINYFYPYMEKYYNENFKV*" /label="liaE CDS" gene complement(3506847..3507806) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /label="liaE gene" downshifts 3507795 /Source="Nicolas_upshifts" /id="D2078" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.40583" /MaxDrop="2.5017" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3507842..3507845 /Source="Nicolas_upshift_promotors" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3507850 /Source="Nicolas_upshifts" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3507864..3508013) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 17921301, 28644475; Product type r: regulator" /codon_start=1 /transl_table=11 /product="precursor of exported modified peptide (epipeptide) controlling LiaRS activity" /protein_id="NP_391898.1" /db_xref="EnsemblGenomes-Gn:BSU40180" /db_xref="EnsemblGenomes-Tr:CAB16055" /db_xref="InterPro:IPR023898" /db_xref="SubtiList:BG11479" /db_xref="UniProtKB/Swiss-Prot:Q45596" /translation="MKKEITNNETVKNLEFKGLLDESQKLAKVNDLWYFVKSKENRWI LGSGH*" /label="liaD CDS" gene complement(3507864..3508013) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /label="liaD gene" downshifts complement(3507871) /Source="Nicolas_upshifts" /id="D2079" /incds=0 /nref=99 /ntot=172 /MaxReadThrough="7.62324" /MaxDrop="6.01674" /score="7.49162587" /energy="-10.5" /TU="U3163" /idTUdmin="U3167" /TUdmin=2794 /isTUend="FALSE" /label="downshifts" misc_feature 3507922..3507939 /Source="Nicolas_upshift_promotors" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3507927 /Source="Nicolas_upshifts" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3508008 /Source="Nicolas_upshifts" /id="D2080" /incds=0 /nref=99 /ntot=170 /MaxReadThrough="2.55247" /MaxDrop="5.95806" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3508034..3508053) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3508055) /Source="Nicolas_upshifts" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3508068..3508075) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3508348..3508355 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3508370..3508389 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3508374 /Source="Nicolas_upshifts" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="upshifts" CDS 3508485..3510410 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /EC_number="3.1.3.11" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:221467, 9696785, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 221467, 9696785, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphatase" /protein_id="NP_391899.2" /db_xref="EnsemblGenomes-Gn:BSU40190" /db_xref="EnsemblGenomes-Tr:CAB16056" /db_xref="GOA:Q45597" /db_xref="InterPro:IPR009164" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11478" /db_xref="UniProtKB/Swiss-Prot:Q45597" /translation="MESKYLDLLAQKYDCEEKVVTEIINLKAILNLPKGTEHFVSDLH GEYQAFQHVLRNGSGRVKEKIRDIFSGVIYDREIDELAALVYYPEDKLKLIKHDFDAK EALNEWYKETIHRMIKLVSYCSSKYTRSKLRKALPAQFAYITEELLYKTEQAGNKEQY YSEIIDQIIELGQADKLITGLAYSVQRLVVDHLHVVGDIYDRGPQPDRIMEELINYHS VDIQWGNHDVLWIGAYSGSKVCLANIIRICARYDNLDIIEDVYGINLRPLLNLAEKYY DDNPAFRPKADENRPEDEIKQITKIHQAIAMIQFKLESPIIKRRPNFNMEERLLLEKI DYDKNEITLNGKTYQLENTCFATINPEQPDQLLEEEAEVIDKLLFSVQHSEKLGRHMN FMMKKGSLYLKYNGNLLIHGCIPVDENGNMETMMIEDKPYAGRELLDVFERFLREAFA HPEETDDLATDMAWYLWTGEYSSLFGKRAMTTFERYFIKEKETHKEKKNPYYYLREDE ATCRNILAEFGLNPDHGHIINGHTPVKEIEGEDPIKANGKMIVIDGGFSKAYQSTTGI AGYTLLYNSYGMQLVAHKHFNSKAEVLSTGTDVLTVKRLVDKELERKKVKETNVGEEL LQEVAILESLREYRYMK*" /label="fbp CDS" gene 3508485..3510410 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /label="fbp gene" S_feature 3510411..3511775 /Source="Nicolas_S_feature" /locus_tag="new_4130045_4131409" /HighExp="Lbstat, dia5, C30, Gly, Etha, dia15, C90, Fru, G135, Mal" /AntisenseName="yydD" /AntisenseCor="0.44422072328838003" /AntisenseRegPval="-13.7" /CDS_PredictionProba="0.22050400000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1544" S_feature complement(3510623..3510943) /Source="Nicolas_S_feature" /locus_tag="new_4130257_4130577_c" /HighExp="Cold, C30, M/G, S8, Fru, nit, Glu, BMM, Heat, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1545" CDS complement(3510944..3512704) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative DNA wielding protein" /protein_id="NP_391900.1" /db_xref="EnsemblGenomes-Gn:BSU40200" /db_xref="EnsemblGenomes-Tr:CAB16057" /db_xref="InterPro:IPR018760" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11477" /db_xref="UniProtKB/Swiss-Prot:Q45598" /translation="MIVMIIKNLFVCNSQEILKEYKFNAVGVNIILGEKREDHEETNG VGKSTMIECISFLLGKTISNFYTTNEILLNKNVFIVLNVEIDGNQVFLARSFNSPKHG YTLHDTSLTFNLEEWKKVSISVYKKFIEKEILKGEKEDITFAALREYIIRDEKTGFND IVLPNRGGLKQYKLLNYLFTLPTHTEKNIKVFRDKIEKLNSEIKLIESMNINIGDLKV KEDELINEIEDYNRVIYQTKTANKYNNDTNRYSEIKSELNKIQNEIFENEHICKQYQR NIDDLNKKVTKIKELENIEKFYEDIVGFFPEEVKQNYNKVQEFYNFMVESRGSYFKDK IVKIQADLKKLNIKKQGLTEQLESSARILKSNNFIEDISIVMEEQRRKEIELAEVRLR ISDYDKKNHIFDKINELQHEILRVNSMYYDEFQSYSAIVSELKKLFNNLMDVTYNQHG FLDFEYDNRISNAKQSTTGRIKISCSIPDERSHGRLHMKINIFDLTWFLYRCINKCSL NILIHDGSYSNPDPHVKGTLLKHINSSLLENRIGQYFVTINKNELLLDDLQELESKGM IVAKLDRNNEDKNRFFGFRF*" /label="yydD CDS" gene complement(3510944..3512704) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /label="yydD gene" downshifts complement(3510987) /Source="Nicolas_upshifts" /id="D2081" /incds=0 /nref=11 /ntot=199 /MaxReadThrough="4.99391" /MaxDrop="4.47843" /score="7.49162587" /energy="-10.5" /TU="U3167" /idTUdmin="U3167" /TUdmin="-322" /isTUend="FALSE" /label="downshifts" misc_feature 3511772..3511773 /Source="Nicolas_upshift_promotors" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3511777 /Source="Nicolas_upshifts" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3512704..3513102) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391901.1" /db_xref="EnsemblGenomes-Gn:BSU40210" /db_xref="EnsemblGenomes-Tr:CAB16058" /db_xref="SubtiList:BG11476" /db_xref="UniProtKB/Swiss-Prot:Q45599" /translation="MIDLKIETAENILKYSYVLLENEFKNIQIGNDLIPLVNNSPLKK EKAERPEMNHFLLTKYNAVEENILYSSKILYELLEKEKHIDQLFLDYAKSQGIIINLN IERILYLSLTFLYSLGKVSFNQNMISRTES*" /label="yydC CDS" gene complement(3512704..3513102) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /label="yydC gene" CDS complement(3513095..3514540) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphohydrolase" /protein_id="NP_391902.1" /db_xref="EnsemblGenomes-Gn:BSU40220" /db_xref="EnsemblGenomes-Tr:CAB16059" /db_xref="GOA:Q45600" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11475" /db_xref="UniProtKB/Swiss-Prot:Q45600" /translation="MKVRFLQISDLHFQFQNYDTIVMRDKLLDFIEVLRRESDFDFLL LTGDIAHKGDVYNEDVKEYLNGIIKSMGLSKNNVHLVPGNHDISRDMTRTLLIDSIMK SPNPSEMLDKLDQKATNILVEGQRKFFDFYEDFMGVKYPEEDLHFLYQSEKYNVLSIN TCLLSDKKGEEGTLLTAQMKLYKAIRKMNKEKNKGKVLNIAIGHHTLGCIESSERESI KAHFDDYFIDLYLAGHVHDSSFNITANTNENPFLELVSGAIIKDEYATPEFISVDVNL DNGETEVTYYIWNTEYKYWSKNNQGGRRLQEGKLNYKINRLESLIEKEIEDNDDKIDE DEFKSFIIDFHEYRESYKTFTSNFDNQIGLDKKFYDMKSGETFKRKFDSYSEYFGVIN HIMDSTSYVSADKKELIAETIVDKYLEFHNQYNNGDEIFVKIVNEIYLECHSVLPYSK ALTKKYIKILTCWCIYECEIFNDNKRSVKND*" /label="yydB CDS" gene complement(3513095..3514540) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /label="yydB gene" promotor_-35 3513790..3513797 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3513809..3513828 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3513819..3514868 /Source="Nicolas_S_feature" /locus_tag="new_4133453_4134502" /HighExp="C30, Salt, Gly, S8, Etha, LPhT, T0.30H, Heat, C90, M9-stat" /AntisenseName="yydB" /AntisenseCor="0.36202116146901597" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.431" /TUlongSig="NA" /TUlongPSig="NA" /label="S1546" upshifts 3513819 /Source="Nicolas_upshifts" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3514541..3514801) /Source="Nicolas_S_feature" /locus_tag="new_4134175_4134435_c" /HighExp="Cold, M0t90, Lbtran, M40t90, Lbstat, T0.30H, MG 150, M40t45, Gly, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1547" CDS complement(3514802..3515281) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /EC_number="2.1.1.177" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18755835, 20817755, 22411911, 22720735, 28428565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (pseudouridine1915-N3)-methyltransferase" /protein_id="NP_391903.1" /db_xref="EnsemblGenomes-Gn:BSU40230" /db_xref="EnsemblGenomes-Tr:CAB16060" /db_xref="GOA:Q45601" /db_xref="InterPro:IPR003742" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1TO0" /db_xref="SubtiList:BG11474" /db_xref="UniProtKB/Swiss-Prot:Q45601" /translation="MNINIVTIGKLKEKYLKQGIEEYTKRLSAYAKIDIIELPDEKAP ENLSDQDMKIIKDKEGDRILSKISPDAHVIALAIEGKMKTSEELADTIDKLATYGKSK VTFVIGGSLGLSDTVMKRADEKLSFSKMTFPHQLMRLILVEQIYRAFRINRGEPYHK* " /label="rlmH CDS" gene complement(3514802..3515281) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /label="rlmH gene" S_feature complement(3515282..3515361) /Source="Nicolas_S_feature" /locus_tag="new_4134916_4134995_c" /HighExp="dia5, LBGtran, T0.30H, Diami, Cold, M0t90, dia0, M0t45, M40t45, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1548" CDS complement(3515362..3515532) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097800.1" /db_xref="EnsemblGenomes-Gn:BSU40239" /db_xref="EnsemblGenomes-Tr:CAX52715" /db_xref="InterPro:IPR025626" /db_xref="UniProtKB/Swiss-Prot:C0H3T9" /translation="MKQAYYSCEEHIETVLDMYIDDHELPPEIRKIEHTNSLSTACEL CGDPAVYIVGNE*" /label="yyzF CDS" gene complement(3515362..3515532) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /label="yyzF gene" promotor_-10 complement(3515573..3515592) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3515589) /Source="Nicolas_upshifts" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3515606..3515611) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3515655..3515662 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3515675..3515694 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3515692 /Source="Nicolas_upshifts" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="upshifts" CDS 3515717..3516130 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21911367; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391904.1" /db_xref="EnsemblGenomes-Gn:BSU40240" /db_xref="EnsemblGenomes-Tr:CAB16061" /db_xref="SubtiList:BG11472" /db_xref="UniProtKB/Swiss-Prot:Q45603" /translation="MRFRWVWLFVIMLLLAECQPSYWVLEKDRIGEGSPDLEIYANYL QMHDDVKGYQVFTISEGKKMVVVSLGSSEKDKKLEVSDVKFSSKETIVTVERKPAPTA NEKNPFILIGLDKIEGDLIVQDETGDRFEETDYQQ*" /label="yycS CDS" gene 3515717..3516130 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /label="yycS gene" downshifts 3516110 /Source="Nicolas_upshifts" /id="D2082" /incds=0 /nref=17 /ntot=131 /MaxReadThrough="1.50241" /MaxDrop="5.73792" /score="16.0382598" /energy="-10.8" /TU="NA" /idTUdmin="U3168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3516164..3517390) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18820069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_391905.1" /db_xref="EnsemblGenomes-Gn:BSU40250" /db_xref="EnsemblGenomes-Tr:CAB16062" /db_xref="GOA:Q45604" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014184" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11471" /db_xref="UniProtKB/Swiss-Prot:Q45604" /translation="MGGMALTGNKAVVYKGKGTVAVEDIGYPELILRDGPGVPKANVN RKCEHGVILKVITTNICGSDQHMVRGRTTAPEGLVLGHEITGEVIETGRDVEFIKKGD IVSVPFNIACGRCVMCKTQKTHVCLNVNPDRPGSAYGYVDMGGWVGGQSEYVMVPYAD FQLLVFPDKEQALEKILDLTMLSDIFPTGFHGAYTAGVQTGSTVYIAGAGPVGLAAAH SAQLLGASTVIVGDLNEDRLAQARSFGCETVNVQKHDRLGEQIEQILGEPTVDAAVDC VGFEASGHGNQGEAPAAVLNSIMDVTQVGGSLGIPGLYVTEDPGAKDADAKTGSLKIR FGLGWAKAHTFVTGQTPAMTYNRNLMKAILSGRAQIAKAVNATVISLDDAPKGYSDFD KGAAKKFVIDPHGTLK*" /label="yycR CDS" gene complement(3516164..3517390) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /label="yycR gene" downshifts complement(3516179) /Source="Nicolas_upshifts" /id="D2083" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="0.14321" /MaxDrop="4.77892" /score="8.82768619" /energy="-6.2" /TU="NA" /idTUdmin="U3169" /TUdmin=7 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3517413..3517431) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3517418) /Source="Nicolas_upshifts" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3517443..3517451) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3517453..3517623) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097801.1" /db_xref="EnsemblGenomes-Gn:BSU40259" /db_xref="EnsemblGenomes-Tr:CAX52716" /db_xref="GOA:C0H3U0" /db_xref="UniProtKB/Swiss-Prot:C0H3U0" /translation="MQTNRVILLAVMICLVSAITVFLLNGCKVDFLDIGGTIIGCFLG IFVVVRIQKKQS*" /label="yyzG CDS" gene complement(3517453..3517623) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /label="yyzG gene" promotor_-10 complement(3517642..3517660) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3517660) /Source="Nicolas_upshifts" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3517674..3517680) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3517728..3517976) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391906.1" /db_xref="EnsemblGenomes-Gn:BSU40260" /db_xref="EnsemblGenomes-Tr:CAB16063" /db_xref="GOA:Q45605" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG11470" /db_xref="UniProtKB/Swiss-Prot:Q45605" /translation="MGAIAVLFIVFGFPIVAGVFGIAGHFLFKRFWVAPLIVLITSLI LLVTLASGNSSFIFWVVMYTAIALVTSVATLFLRKFFE*" /label="yycQ CDS" gene complement(3517728..3517976) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /label="yycQ gene" CDS complement(3517992..3519155) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812, 16291680" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391907.2" /db_xref="EnsemblGenomes-Gn:BSU40270" /db_xref="EnsemblGenomes-Tr:CAB16064" /db_xref="InterPro:IPR011047" /db_xref="SubtiList:BG11469" /db_xref="UniProtKB/Swiss-Prot:Q45606" /translation="MKKWMITIAMLILAGIALFVFISPLKSHKTVSQQDLRNPDFLDD KEVLLYFSSSADQDAFGGGKSYALFISHDGTLSSFQMKGLELGSAKVHGDSVMLEDKN TIYTIKNGLRSHKRTYQHTGDSAGFLQNTDGFYTLYNSGYDKKGDGYRSELYRQMDGE WKKDVIPYYIRASGFHDGAIYALVPTDDGKGYQLLQIQADQKKLTYLSITEWQYREGA SVESQLAVDDQAVYVMVRGQKAHDLYQMVKINKKSGEVELHDIAEYKNDEQTIYSSMP FSFKNSFFPYDGNLYFIDGFGKVHKIDAKTGKTSIVFTLSPDKMKAEFKEITQKGSSL YFFTYTYHKPAYIEQYSLKTGKKMKEKEIGKVKDVVTPKSHLKLYDVEVMKRF*" /label="yycP CDS" gene complement(3517992..3519155) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /label="yycP gene" promotor_-10 complement(3518026..3518044) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3518034) /Source="Nicolas_upshifts" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3518056..3518064) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3519166..3519903) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_391908.1" /db_xref="EnsemblGenomes-Gn:BSU40280" /db_xref="EnsemblGenomes-Tr:CAB16065" /db_xref="SubtiList:BG11468" /db_xref="UniProtKB/Swiss-Prot:Q45607" /translation="MKLKKRVSMFLVALTMCGGLFVTPAKAVKTTNYAEEIAALQPGT TPEEIMKSASQIAKQQHVKQDVILKQFYKEITADKAEGDRLAKESGMSIMGGSSGTKK LPTSAKGNIYYTNSYTAYYNHGHVGMYSAADKIVESVPSDGVRQIAYNARDVEDNSIV QTVSVSSSQKTAAADWAVSKVGDPYSFNFVNNRNTGHDGAKNCSKLLWSAFLLKAGID IDSNGGLGVYPRDITSSSYTTTIMTIY*" /label="yycO CDS" gene complement(3519166..3519903) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /label="yycO gene" promotor_-10 complement(3519945..3519963) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3519951) /Source="Nicolas_upshifts" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3519977..3519985) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3520045..3520515) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14635137, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391909.1" /db_xref="EnsemblGenomes-Gn:BSU40290" /db_xref="EnsemblGenomes-Tr:CAB16066" /db_xref="GOA:O32293" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1ON0" /db_xref="PDB:1UFH" /db_xref="SubtiList:BG11467" /db_xref="UniProtKB/Swiss-Prot:O32293" /translation="MTIMLTPMQTEEFRSYLTYTTKHYAEEKVKAGTWLPEDAQLLSK QVFTDLLPRGLETPHHHLWSLKLNEKDIVGWLWIHAEPEHPQQEAFIYDFGLYEPYRG KGYAKQALAALDQAARSMGIRKLSLHVFAHNQTARKLYEQTGFQETDVVMSKKL*" /label="yycN CDS" gene complement(3520045..3520515) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /label="yycN gene" downshifts complement(3520058) /Source="Nicolas_upshifts" /id="D2084" /incds=0 /nref=1 /ntot=78 /MaxReadThrough="3.78599" /MaxDrop="2.94893" /score="8.04802973" /energy="-7.6" /TU="U3175" /idTUdmin="U3174" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3520516..3520586) /Source="Nicolas_S_feature" /locus_tag="new_4140150_4140220_c" /HighExp="S4, S5, S6, LoTm, S3, S7, S8, B36, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1549" promotor_-35 3520547..3520553 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3520567..3520586 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3520568..3520587) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3520568 /Source="Nicolas_upshifts" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3520586) /Source="Nicolas_upshifts" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3520588..3520863) /Source="Nicolas_S_feature" /locus_tag="new_4140222_4140497_c" /HighExp="S4, S5, S6, S7, S8, S3, B36, BT, LoTm, T5.0H" /AntisenseName="rapG" /AntisenseCor="-0.20647217228472101" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1550" promotor_-35 complement(3520602..3520609) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3520626..3521723 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391910.1" /db_xref="EnsemblGenomes-Gn:BSU40300" /db_xref="EnsemblGenomes-Tr:CAB16067" /db_xref="GOA:O32294" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11466" /db_xref="UniProtKB/Swiss-Prot:O32294" /translation="MNKIAPAEIASMLNDWYLAIKKHEVEESSRLFEEVKPLLDDMEE DQEVLAYFSLLELRHKVLLHEARGQGFQHEEPSHMNATSDMLKYYFFLFEGMYEAYKN NYDIAIGLYKDAEQYLDNIPDPIEKAEFHLKVGKLYYKLGQNIVSLNHTRQAVKTFRE ETDYKKKLASALITMSGNFTEMSQFEEAEAYLDEAIRITSELEDHFFEAQLLHNFGLL HAQSGKSEEAVSKLEEALQNDEYARSAYYYHSAYLLIRELFKIKKKEQALSYYQDVKE KLTAEPNRICEAKIDILYAIYAEGGHAETFHLCKQHMDDLLSEKEYDSVRELSILAGE RYRELELYKEAAHFFYEALQIEELIKRTEVI*" /label="rapG CDS" gene 3520626..3521723 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /label="rapG gene" promotor_-10 complement(3520854..3520872) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-10" upshifts complement(3520863) /Source="Nicolas_upshifts" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="upshifts" promotor_-35 complement(3520887..3520892) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-35" promotor_-35 3521447..3521455 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3521467..3521485 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3521480 /Source="Nicolas_upshifts" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="upshifts" CDS 3521724..3521840 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878, 16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878, 16816200; Product type r: regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapG" /protein_id="NP_391911.1" /db_xref="EnsemblGenomes-Gn:BSU40310" /db_xref="EnsemblGenomes-Tr:CAB16068" /db_xref="InterPro:IPR030968" /db_xref="SubtiList:BG11465" /db_xref="UniProtKB/Swiss-Prot:O32295" /translation="MKRFLIGAGVAAVILSGWFIADHQTHSQEMKVAEKMIG*" /label="phrG CDS" gene 3521724..3521840 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /label="phrG gene" downshifts 3521829 /Source="Nicolas_upshifts" /id="D2085" /incds=0 /nref=39 /ntot=249 /MaxReadThrough="4.8963" /MaxDrop="7.30713" /score="31.0184314" /energy="-13.7" /TU="U3173,U3176" /idTUdmin="U3173" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3522077..3522967) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /EC_number="3.5.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginase" /protein_id="NP_391912.1" /db_xref="EnsemblGenomes-Gn:BSU40320" /db_xref="EnsemblGenomes-Tr:CAB16069" /db_xref="GOA:P39138" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR014033" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG10932" /db_xref="UniProtKB/Swiss-Prot:P39138" /translation="MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTV EDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIG TLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAP KIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGV HLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHK NKTGKTAVELVESLLGKKLL*" /label="argI CDS" gene complement(3522077..3522967) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /label="argI gene" downshifts complement(3522083) /Source="Nicolas_upshifts" /id="D2086" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.33097" /MaxDrop="3.38667" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" downshifts complement(3522145) /Source="Nicolas_upshifts" /id="D2087" /incds=1 /nref=28 /ntot=201 /MaxReadThrough="5.16507" /MaxDrop="5.79932" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-151" /isTUend="FALSE" /label="downshifts" CDS complement(3523041..3524444) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7540694, 10648515, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 10648515, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arginine/ornithine/gamma-aminobutyrate permease" /protein_id="NP_391913.1" /db_xref="EnsemblGenomes-Gn:BSU40330" /db_xref="EnsemblGenomes-Tr:CAB16070" /db_xref="GOA:P39137" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10933" /db_xref="UniProtKB/Swiss-Prot:P39137" /translation="MNTNQDNGNQLQRTMKSRHLFMISLGGVIGTGFFLGTGFTINQA GPLGAVLSYLVGGFIMFLTMLCLGELAVAFPVSGSFQTYATKFISPAFGFAFGWLYWL GWAVTCAIEFLSAGQLMQRWFPHIDVWIWCLVFAALMFILNAITTKAFAESEFWFSGI KILIILLFIILGGAAMFGLIDLKGGEQAPFLTHFYEDGLFPNGIKAMLITMITVNFAF QGTELIGVAAGESEDPEKTIPRSIKQTVWRTLVFFVLSIIVIAGMIPWKQAGVVESPF VAVFEQIGIPYAADIMNFVILIALLSVANSGLYASTRILYAMANEGQAFKALGKTNQR GVPMYSLIVTMAVACLSLLTKFAQAETVYMVLLSLAGMSAQVGWITISLSQIMFRRKY IREGGKIEDLKFKTPLYPVLPLIGLTLNTVVLISLAFDPEQRIALYCGVPFMIICYII YHVVIKKRQQANRQLEL*" /label="rocE CDS" gene complement(3523041..3524444) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /label="rocE gene" S_feature complement(3524445..3524666) /Source="Nicolas_S_feature" /locus_tag="new_4144079_4144300_c" /HighExp="Lbstat, S0, LPh, T1.30H, HPh, T2.0H, LPhT, BI, M0t90, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.884" /TUlongSig="NA" /TUlongPSig="NA" /label="S1551" CDS complement(3524667..3525872) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /EC_number="2.6.1.13" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7540694, 9383188, 22720735, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 9383188, 22720735, 23869754; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine aminotransferase" /protein_id="NP_391914.1" /db_xref="EnsemblGenomes-Gn:BSU40340" /db_xref="EnsemblGenomes-Tr:CAB16071" /db_xref="GOA:P38021" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR010164" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR034757" /db_xref="SubtiList:BG10722" /db_xref="UniProtKB/Swiss-Prot:P38021" /translation="MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNE YMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEM ILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEY KRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAI CKEENVLFIADEIQTGLGRTGKTFACDWDGIVPDMYILGKALGGGVFPISCIAADREI LGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGEYFKSELESIDSPVI KEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIE KIKHVLRNA*" /label="rocD CDS" gene complement(3524667..3525872) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /label="rocD gene" misc_feature complement(3525929..3525947) /Source="Nicolas_upshift_promotors" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3525932) /Source="Nicolas_upshifts" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3526042..3526047 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3526062..3526081 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3526077 /Source="Nicolas_upshifts" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="upshifts" CDS 3526113..3527498 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9194709, 12533460, 12634342, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9194709, 12533460, 12634342, 23869754; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NtrC/NifA family)" /protein_id="NP_391915.1" /db_xref="EnsemblGenomes-Gn:BSU40350" /db_xref="EnsemblGenomes-Tr:CAB16072" /db_xref="GOA:P38022" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG10723" /db_xref="UniProtKB/Swiss-Prot:P38022" /translation="MVKDSEFLTLVFQSILDEIDVGLHVVDEHGNTIVYNNKMMQIED MEKHDVLNKNLMDVFMFSKQQDSTLVQALQEGKTIKNVKQSYFNNKGQEITTINHTYP IVQDGKIRGAVEIAKDVTKLERLIRENMNKKGSTTYTFDSILGTSPAIQDVIENAKRA TRTSSSVLLAGETGTGKELFAQSIHNGSDRSGGPFISQNCAALPDSLVESILFGTKKG AFTGAVDQPGLFEQAHGGTLLLDEINSLNLSLQAKLLRALQERKIRRIGSTKDTPIDV RIIATMNEDPIDAIAGERMRKDLYYRLSVVTLIIPPLRERKEDILLLASEFIQKNNHL FQMNVEHISDDVKQFFLSYDWPGNIRELEHMIEGAMNFMTDEQTITASHLPYQYRMKI KPADIPEPETPRHQPAADLKEKMESFEKYVIENVLRKHGHNISKAAQELGISRQSLQY RLKKFSHSSNE*" /label="rocR CDS" gene 3526113..3527498 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /label="rocR gene" CDS complement(3527480..3527668) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17198402; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative sensor protein" /db_xref="PSEUDO:CAX52717.1" /translation="MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIG RGTVFLIRLPAPDYSLDE*" /label="yyzO CDS" gene complement(3527480..3527668) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /pseudo /label="yyzO gene" CDS complement(3527785..3527913) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514013.1" /translation="MPGCFDMQKKLNRGHARSVEKGYIEYEEKYKMDVTRETANGS*" /label="hypothetical protein CDS" gene complement(3527785..3527913) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /label="gene" downshifts 3527837 /Source="Nicolas_upshifts" /id="D2088" /incds=0 /nref=1 /ntot=146 /MaxReadThrough="0.86899" /MaxDrop="2.90385" /score="20.2816165" /energy="-10.8" /TU="NA" /idTUdmin="U3178" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS complement(3527933..3529135) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /EC_number="3.4.21.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 16030236, 25384476" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 16030236, 25384476; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation membrane serine protease" /protein_id="NP_391916.1" /db_xref="EnsemblGenomes-Gn:BSU40360" /db_xref="EnsemblGenomes-Tr:CAB16073" /db_xref="GOA:P39668" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG11054" /db_xref="UniProtKB/Swiss-Prot:P39668" /translation="MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPY LSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTKIVSNMSPAVVGVVNIQKSDIWG ESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVD SNGDGQPDWNAEVLQTDAAINPGNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPS KLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPKNVTNGAVVMGVDAF SPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKL SSADQLGS*" /label="htrC CDS" gene complement(3527933..3529135) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /label="htrC gene" downshifts complement(3527957) /Source="Nicolas_upshifts" /id="D2089" /incds=0 /nref=134 /ntot=253 /MaxReadThrough="2.3073" /MaxDrop="5.06813" /score="5.6507537" /energy="-15" /TU="NA" /idTUdmin="U3179" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3529167..3529178) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3529167) /Source="Nicolas_upshifts" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3529193..3529199) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3529217..3530011) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9829949, 16030236, 21169496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391917.2" /db_xref="EnsemblGenomes-Gn:BSU40370" /db_xref="EnsemblGenomes-Tr:CAB16074" /db_xref="GOA:C0SP91" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11464" /db_xref="UniProtKB/Swiss-Prot:C0SP91" /translation="MSLQFSVLASGSTGNAFYLETEDHAFLVDAGLSGKAMDGLMAQI GRKLDDVDGIFVTHEHSDHIKGLGVVARKYKLPIYANEKTWKAMENQIGKIDTDQKFV FPMETVKSFGGLDVESFGVSHDAAEPMFYVFHYSGRKLALMTDTGYVSDRMKGIIRSA NVFVFESNHDVGMLQMGRYPWSIKRRILSDVGHVSNEDAALAMTDVIGDETSRIYLAH LSQDNNMKELARMSVQQTLASKGFVTGETFDLYDTDPKKATPLCAV*" /label="walJ CDS" gene complement(3529217..3530011) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /label="walJ gene" CDS complement(3530033..3530875) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 17307848, 17307850, 18408157, 21219466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 17307848, 17307850, 18408157, 21219466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK" /protein_id="NP_391918.1" /db_xref="EnsemblGenomes-Gn:BSU40380" /db_xref="EnsemblGenomes-Tr:CAB16075" /db_xref="GOA:Q45612" /db_xref="InterPro:IPR018604" /db_xref="PDB:2O3O" /db_xref="SubtiList:BG11463" /db_xref="UniProtKB/Swiss-Prot:Q45612" /translation="MEWNKTKSIFIVAFLILDIFLGYQFFQKWQATGKEYEVIKNDVE HDMKADHITYEGLNKEATEGYRITANQKSFSKEEIEALKDQKPLMDMPSDDHKVTSLK MKFANPIALSKKDIEDDAQALVSSKIQDGEKYKLWKVDKSKKEIIFFQTYEGHYIYQK TDNPSNMIGQVVLHLNGKNEVVSYDQTTLETFKQIQKESLITEMDAVELLYYQNQLKE YSTVKSCKFGYVAQYPLTSTQVLAPVWRITVEYEKKVNGEKKTVQEYFTVNALESTIL DTDQ*" /label="walI CDS" gene complement(3530033..3530875) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /label="walI gene" CDS complement(3530862..3532229) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 16600972, 17307850, 26999783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 16600972, 17307850, 26999783; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK(YycFG)" /protein_id="NP_391919.1" /db_xref="EnsemblGenomes-Gn:BSU40390" /db_xref="EnsemblGenomes-Tr:CAB16076" /db_xref="GOA:Q794W0" /db_xref="InterPro:IPR009996" /db_xref="PDB:2FGT" /db_xref="SubtiList:BG11462" /db_xref="UniProtKB/Swiss-Prot:Q794W0" /modified_by="User" /translation="MKRENIKTILLTVLVVISLVFTWGIWTFQPNFSEGSSSTESTVR VKHKIEKTTQKLSETVRPRDMFIHDDGAHYKVDDNALYEEIWSDLPHWDVKGIKDISD QYDKAGFKSWFYGIGGSEAKLDLQFSDTIPIDIFQTLFKWSNQSFEYSSFDHILIPFN ETKANKKIYLVSYSKQLILEVTVESANYRNIMNDLKNRQSNMPAFSLFSIGSKKEFLL PNKPLTMDKKEFVTESIKTNTFKQALFSDPSIVREDSNYTNRNVLTDGISRLDVNLSQ RQVQFQQRNLVQSTSYQTGELIKKSQKYLEDTGSWTDHYQFFNINDSQQLSFYIFMDQ IPVINSTAKPFGATSAITVQWANDDILSYKRPNYSLGTNPIKTSETELMGGSEVKMLL SKQTAYDTDKIDQIFLAYQLVSTSTNDDPLVELEPVWAMKVNGKIVPITKDLLRKEGA NSGVE*" /label="Delta6_BSU_40390_SNPvariant" gene complement(3530862..3532229) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /modified_by="User" /label="Delta6_BSU_40390_SNPvariant" Polymorphism join(3531456,3531458) /Source="geneious" /ID="SNP_BsDelta6_4151091_4151091" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="N -> T" /CDS_Position=773 /Change="T -> G" /Codon_Change="AAC -> ACC" /Coverage=184 /locus_tag="BSU_40390" /Protein_Effect="Substitution" /Reference_Frequency="0.5%" /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="Delta6_BSU_40390_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(3532219..3534054) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YycG]" /protein_id="NP_391920.1" /db_xref="EnsemblGenomes-Gn:BSU40400" /db_xref="EnsemblGenomes-Tr:CAB16077" /db_xref="GOA:Q45614" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3SL2" /db_xref="SubtiList:BG11461" /db_xref="UniProtKB/Swiss-Prot:Q45614" /translation="MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISS YEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTKSDEVREISFVDKSYEV VGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEV VGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAM ELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGV IATNRNGAIILLNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQDSMLLEI ERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPL TTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNRE WIQIVRFMSLIIDRFEMTKEQHVEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYS PEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGL GLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDEA*" /label="walK CDS" gene complement(3532219..3534054) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /label="walK gene" CDS complement(3534062..3534769) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YycF]" /protein_id="NP_391921.1" /db_xref="EnsemblGenomes-Gn:BSU40410" /db_xref="EnsemblGenomes-Tr:CAB16078" /db_xref="GOA:P37478" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2D1V" /db_xref="PDB:2ZWM" /db_xref="PDB:3F6P" /db_xref="SubtiList:BG10001" /db_xref="UniProtKB/Swiss-Prot:P37478" /translation="MDKKILVVDDEKPIADILEFNLRKEGYEVHCAHDGNEAVEMVEE LQPDLILLDIMLPNKDGVEVCREVRKKYDMPIIMLTAKDSEIDKVIGLEIGADDYVTK PFSTRELLARVKANLRRQLTTAPAEEEPSSNEIHIGSLVIFPDAYVVSKRDETIELTH REFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPNW IVTRRGVGYYLRNPEQD*" /label="walR CDS" gene complement(3534062..3534769) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /label="walR gene" S_feature complement(3534770..3534866) /Source="Nicolas_S_feature" /locus_tag="new_4154404_4154500_c" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, dia0, LBGstat, dia5, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="1, 1, 0.11" /TUlongSig="SigA" /TUlongPSig="0.986" /label="S1552" promotor_-10 complement(3534854..3534873) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3534866) /Source="Nicolas_upshifts" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3534868..3535060) /Source="Nicolas_S_feature" /locus_tag="new_4154502_4154694_c" /HighExp="G180, Paraq, Oxctl, G135, G150, H2O2, T0.30H, BMM, Cold, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="0.986, 1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1553" promotor_-35 complement(3534889..3534892) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3535060) /Source="Nicolas_upshifts" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="upshifts" misc_feature complement(3535070..3535089) /Source="Nicolas_upshift_promotors" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3535152) /Source="Nicolas_upshifts" /id="D2090" /incds=0 /nref=8 /ntot=83 /MaxReadThrough="5.21091" /MaxDrop="5.81799" /score="24.1725164" /energy="-10.6" /TU="U3183,U3184" /idTUdmin="U3181" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" tRNA complement(3535153..3535225) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Phe tRNA" gene complement(3535153..3535225) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /label="trnY-Phe gene" tRNA complement(3535261..3535337) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Asp tRNA" gene complement(3535261..3535337) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /label="trnY-Asp gene" S_feature complement(3535338..3535418) /Source="Nicolas_S_feature" /locus_tag="new_4154972_4155052_c" /HighExp="Oxctl, Heat, BMM, Paraq, UNK1, H2O2, C30, MG 45, G180, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1554" tRNA complement(3535419..3535490) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Glu tRNA" gene complement(3535419..3535490) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /label="trnY-Glu gene" tRNA complement(3535500..3535575) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Lys tRNA" gene complement(3535500..3535575) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /label="trnY-Lys gene" misc_feature 3535547..3535563 /Source="Nicolas_upshift_promotors" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3535560 /Source="Nicolas_upshifts" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3535576..3535672) /Source="Nicolas_S_feature" /locus_tag="new_4155210_4155306_c" /HighExp="LBGstat, C30, UNK1, Oxctl, HPh, Heat, MG 150, BMM, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1555" promotor_-10 complement(3535656..3535675) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3535672) /Source="Nicolas_upshifts" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3535689..3535696) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(3535706..3535807) /Source="Nicolas_upshift_promotors" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3535746) /Source="Nicolas_upshifts" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3535800..3537092) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /EC_number="6.3.4.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1312531, 10368157, 16163456, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1312531, 10368157, 16163456, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate synthetase" /protein_id="NP_391922.1" /db_xref="EnsemblGenomes-Gn:BSU40420" /db_xref="EnsemblGenomes-Tr:CAB16079" /db_xref="GOA:P29726" /db_xref="InterPro:IPR001114" /db_xref="InterPro:IPR018220" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033128" /db_xref="SubtiList:BG10002" /db_xref="UniProtKB/Swiss-Prot:P29726" /translation="MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGNNAGHTIK FDGITYKLHLIPSGIFYKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRA HVILPYHLKLDEVEEERKGANKIGTTKKGIGPAYMDKAARIGIRIADLLDRDAFAEKL ERNLEEKNRLLEKMYETEGFKLEDILDEYYEYGQQIKKYVCDTSVVLNDALDEGRRVL FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPTKIKHVVGVSKAYTTRVGDGP FPTELKDEIGDQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVL AGIETLKICVAYRYKGEIIEEFPASLKALAECEPVYEEMPGWTEDITGAKSLSELPEN ARHYLERVSQLTGIPLSIFSVGPDRSQTNVLRSVYRAN*" /label="purA CDS" gene complement(3535800..3537092) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /label="purA gene" downshifts complement(3535811) /Source="Nicolas_upshifts" /id="D2091" /incds=0 /nref=200 /ntot=241 /MaxReadThrough="2.03104" /MaxDrop="6.53551" /score="13.9967927" /energy="-10.5" /TU="NA" /idTUdmin="U3185" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3537132..3537151) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3537152) /Source="Nicolas_upshifts" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3537166..3537173) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3537298..3537717) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16731985" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391923.1" /db_xref="EnsemblGenomes-Gn:BSU40430" /db_xref="EnsemblGenomes-Tr:CAB16080" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:1TWU" /db_xref="SubtiList:BG10003" /db_xref="UniProtKB/Swiss-Prot:P37479" /translation="MGKRFSSFQAAQIRIARPTGQLDEIIRFYEEGLCLKRIGEFSQH NGYDGVMFGLPHADYHLEFTQYEGGSTAPVPHPDSLLVFYVPNAVELAAITSKLKHMG YQEVESENPYWSNGGVTIEDPDGWRIVFMNSKGISGK*" /label="yycE CDS" gene complement(3537298..3537717) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /label="yycE gene" promotor_-10 complement(3537715..3537726) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3537726) /Source="Nicolas_upshifts" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3537741..3537747) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3537838..3539202) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /EC_number="3.6.4.12" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="replicative DNA helicase" /protein_id="NP_391924.2" /db_xref="EnsemblGenomes-Gn:BSU40440" /db_xref="EnsemblGenomes-Tr:CAB16081" /db_xref="GOA:P37469" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR007692" /db_xref="InterPro:IPR007693" /db_xref="InterPro:IPR007694" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036185" /db_xref="SubtiList:BG10004" /db_xref="UniProtKB/Swiss-Prot:P37469" /translation="MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFY RMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLLEEVGGISYLTDIANSVPTAANI EYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQ NIKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTA FALNIAQNVATKTDESVAIFSLEMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKL TMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILIDYLQLIQGSGRSKDN RQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADI VAFLYRDDYYDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGV PPGA*" /label="dnaC CDS" gene complement(3537838..3539202) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /label="dnaC gene" downshifts complement(3537858) /Source="Nicolas_upshifts" /id="D2092" /incds=0 /nref=3 /ntot=107 /MaxReadThrough="1.37092" /MaxDrop="3.96365" /score="31.6981667" /energy="-12.6" /TU="NA" /idTUdmin="U3187" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3537902) /Source="Nicolas_upshifts" /id="D2093" /incds=1 /nref=9 /ntot=190 /MaxReadThrough="3.89737" /MaxDrop="3.21735" /score="31.6981667" /energy="-12.6" /TU="U3187" /idTUdmin="U3190" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3539233..3539252) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3539247) /Source="Nicolas_upshifts" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3539267..3539269) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3539314..3539320 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-35" promotor_-10 3539335..3539353 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-10" upshifts 3539337 /Source="Nicolas_upshifts" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="upshifts" CDS 3539372..3539572 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391925.1" /db_xref="EnsemblGenomes-Gn:BSU40450" /db_xref="EnsemblGenomes-Tr:CAB16082" /db_xref="InterPro:IPR018691" /db_xref="InterPro:IPR020086" /db_xref="SubtiList:BG10005" /db_xref="UniProtKB/Swiss-Prot:P37480" /translation="MIKKYAITPNVDADGWFIEVENVAPTALYTSKDAAIEKAKQVAK ENSPSKLVIYDQFKNVEEEHSF*" /label="yycD CDS" gene 3539372..3539572 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /label="yycD gene" downshifts 3539542 /Source="Nicolas_upshifts" /id="D2094" /incds=0 /nref=15 /ntot=43 /MaxReadThrough="4.45045" /MaxDrop="5.68737" /score="12.3008592" /energy="-9.5" /TU="U3188" /idTUdmin="U3188" /TUdmin="-352" /isTUend="FALSE" /label="downshifts" S_feature 3539587..3539908 /Source="Nicolas_S_feature" /locus_tag="new_4159220_4159541" /HighExp="Etha, C30, Salt, S6, S8, M9-stat, S7, Oxctl, Paraq, Heat" /AntisenseName="yyzB" /AntisenseCor="0.309580857935493" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1556" CDS complement(3539620..3539823) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391926.1" /db_xref="EnsemblGenomes-Gn:BSU40460" /db_xref="EnsemblGenomes-Tr:CAB16083" /db_xref="SubtiList:BG14171" /db_xref="UniProtKB/Swiss-Prot:O32296" /translation="MHAPLSLLKQMLKEHQIDTEKAVTFEEYIAMRLKLQELMGKFAS IGEWDLYQKAADLMMHIGIQWMK*" /label="yyzB CDS" gene complement(3539620..3539823) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /label="yyzB gene" S_feature complement(3539824..3540124) /Source="Nicolas_S_feature" /locus_tag="new_4159457_4159757_c" /HighExp="S6, S8, S7, S5, S4, BT, B36, T5.0H, S3, C30" /AntisenseName="yycC" /AntisenseCor="-0.77379453158709499" /AntisenseRegPval="-54.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.049" /TUlongSig="NA" /TUlongPSig="NA" /label="S1557" promotor_-35 3539889..3539892 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3539907..3539926 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3539910 /Source="Nicolas_upshifts" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="upshifts" CDS 3539944..3540084 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28546427" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391927.1" /db_xref="EnsemblGenomes-Gn:BSU40470" /db_xref="EnsemblGenomes-Tr:CAB16084" /db_xref="InterPro:IPR025550" /db_xref="SubtiList:BG10006" /db_xref="UniProtKB/Swiss-Prot:P37481" /translation="MRPLQISAETAQKLAESLNLPLEQIMHMPQHILLAKMAELQKED KS*" /label="yycC CDS" gene 3539944..3540084 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /label="yycC gene" S_feature 3540085..3540156 /Source="Nicolas_S_feature" /locus_tag="new_4159718_4159789" /HighExp="Sw, LoTm, Gly, BC, HiOs, B60, S0, T-5.40H, LBGstat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig=1 /label="S1558" upshifts complement(3540132) /Source="Nicolas_upshifts" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3540135..3540149) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3540157..3540161) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3540157..3541365 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25790494; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion ABC transporter (permease)" /protein_id="NP_391928.1" /db_xref="EnsemblGenomes-Gn:BSU40480" /db_xref="EnsemblGenomes-Tr:CAB16085" /db_xref="GOA:P37482" /db_xref="InterPro:IPR004747" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10007" /db_xref="UniProtKB/Swiss-Prot:P37482" /translation="MPHPHNKKIQSFWLITGIIFIAFNLRPAITSVGPVISSIRAELH MSNGAAGFLTALPLLSFAVLSPLAPKLGQRLGNERTLWLGLVILLIGVLTRSTGYTAA LFFGTALIGVGIAIGNVLLPSLIKHKYPEKPGIMISLYTTSMNIFAALASGVSVPLAT QMNGGWKQAFLLWGGLALLALLIWIPQLRHRDTANQTMKLQSSSIWASKMAWYVTIFM GLQSFLFYSSIAWFPEILRSHGIDTATAGWMVSLMQFASLPSTFLTPVLADRVKQQRG IVAALASVYLIGLCGLLAGGSHTLLAIWMIIIGIGQGSSISLALTLIGLRSENAQQAA ALSGMSQSFGYLLAAVGPIFVGYLFDQTHSWTMPIVLLIAALIVMGAAGQGAGRDRYI FQSEKQRNSA*" /label="yycB CDS" gene 3540157..3541365 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /label="yycB gene" downshifts 3541346 /Source="Nicolas_upshifts" /id="D2095" /incds=0 /nref=148 /ntot=242 /MaxReadThrough="3.65611" /MaxDrop="4.91246" /score="26.443484" /energy="-10.1" /TU="U3189" /idTUdmin="U3189" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 3541470..3543527 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase" /protein_id="NP_391929.2" /db_xref="EnsemblGenomes-Gn:BSU40490" /db_xref="EnsemblGenomes-Tr:CAB16086" /db_xref="GOA:P37483" /db_xref="SubtiList:BG10008" /db_xref="UniProtKB/Swiss-Prot:P37483" /translation="MKTKRFDAALILILLAAAFLNTYHIWQDDTANQYYLAAVKSMTQ SFHNFFYASFDPSGFVTVDKPPVVLWIQTIFALIFGVHTWSVIIPQALAGVGSVFLLY RMVKPTFGVGAARIAALVMALTPIAVAVSRTNNIDSMLVFTLLLGSTCLLRAVKQGKL VWLLTAFALIGLAFNMKMMQAFMVLPAFVLFYLIASRVSLKKKIGSLLLSLVLLTGLS LSWAIAVDSASSSSRPYVGSSQTNSVLELAFGYNGTERLFGQTTGLAKGDMNAAGGGN MQNQDNMQAPNGNGSSFSQNGNQSFGNHSQAPQPPNGQTGALNGGGGTPPTGGNGPGN GGPGGGGGKSVNMFGTGDPGPLRLFQSALSGQISWMLPFSLIGLLGAIISWYRDRRGH AAKMKETLFWAAWLVPVAGFFSIAGFFHQYYLIMLAPPIAALSGIGWYTMHRLYKNNK DWSSYLLPAAVLITAVFQVYILSAYTSQIGSVWMYVLGLLGLGITLALLMLKRSHPFS KLLTIISLCVLLLTPVYWSATPLLYGGNSVLPESGPQLKGSANGGNMFSSEVDSGLLS YLRKHNTGEEYLFATLTTVTAAPYIIYENESVMAMGGFNGTDPILTVSELKKLIKEGK VKYFLLSENNSGNSELVSWIKKNGKEITSDEYSGSSSSTNSVQGMRRGPGGESQQTLY LVE*" /label="yycA CDS" gene 3541470..3543527 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /label="yycA gene" downshifts 3543392 /Source="Nicolas_upshifts" /id="D2096" /incds=1 /nref=43 /ntot=203 /MaxReadThrough="1.96363" /MaxDrop="3.65354" /score="19.8733078" /energy="-16.6" /TU="NA" /idTUdmin="U3189" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(3543564..3544013) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 23002217; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L9" /protein_id="NP_391930.1" /db_xref="EnsemblGenomes-Gn:BSU40500" /db_xref="EnsemblGenomes-Tr:CAB16087" /db_xref="GOA:P37437" /db_xref="InterPro:IPR000244" /db_xref="InterPro:IPR009027" /db_xref="InterPro:IPR020069" /db_xref="InterPro:IPR020070" /db_xref="InterPro:IPR020594" /db_xref="InterPro:IPR036791" /db_xref="InterPro:IPR036935" /db_xref="SubtiList:BG10009" /db_xref="UniProtKB/Swiss-Prot:P37437" /translation="MKVIFLQDVKGKGKKGEVKNVADGYAHNFLIKKGLAVEANASNI SALNGQKQKEKKEAIAELEQAKSLKETLEKLTVELSAKSGEGGRLFGSVTSKQITEQL QKDHNIKVDKRKLELPDGIRALGYTNVPVKLHPEVQAVLKVHVKEEA*" /label="rplI CDS" gene complement(3543564..3544013) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /label="rplI gene" downshifts complement(3543578) /Source="Nicolas_upshifts" /id="D2097" /incds=0 /nref=231 /ntot=266 /MaxReadThrough="2.69721" /MaxDrop="6.57383" /score="44.1169256" /energy="-16.6" /TU="NA" /idTUdmin="U3191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3544010..3545989) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /EC_number="3.1.4.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphodiesterase acting on cyclic dinucleotides" /protein_id="NP_391931.1" /db_xref="EnsemblGenomes-Gn:BSU40510" /db_xref="EnsemblGenomes-Tr:CAB16088" /db_xref="GOA:P37484" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR014528" /db_xref="SubtiList:BG10010" /db_xref="UniProtKB/Swiss-Prot:P37484" /translation="MPSFYEKPLFRYPIYALIALSIITILISFYFNWILGTVEVLLLA VILFFIKRADSLIRQEIDAYISTLSYRLKKVGEEALMEMPIGIMLFNDQYYIEWANPF LSSCFNESTLVGRSLYDTCESVVPLIKQEVESETVTLNDRKFRVVIKRDERLLYFFDV TEQIQIEKLYENERTVLAYIFLDNYDDVTQGLDDQTRSTMNSQVTSLLNAWAQEYGIF LKRTSSERFIAVLNEHILTELENSKFSILDEVREKTSFDGVALTLSVGVGASVSSLKE LGDLAQSSLDLALGRGGDQVAIKLPNGKVKFYGGKTNPMEKRTRVRARVISHALKEIV TESSNVIIMGHKFPDMDSIGAAIGILKVAQANNKDGFIVIDPNQIGSSVQRLIGEIKK YEELWSRFITPEEAMEISNDDTLLVIVDTHKPSLVMEERLVNKIEHIVVIDHHRRGEE FIRDPLLVYMEPYASSTAELVTELLEYQPKRLKINMIEATALLAGIIVDTKSFSLRTG SRTFDAASYLRAKGADTVLVQKFLKETVDSYIKRAKLIQHTVLYKDNIAIASLPENEE EYFDQVLIAQAADSLLSMSEVEASFAVARRDEQTVCISARSLGEVNVQIIMEALEGGG HLTNAATQLSGISVSEALERLKHAIDEYFEGGVQR*" /label="gdpP CDS" gene complement(3544010..3545989) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /label="gdpP gene" misc_feature complement(3544491..3544510) /Source="Nicolas_upshift_promotors" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3544494) /Source="Nicolas_upshifts" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3544907..3544914 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3544928..3544946 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3544932..3545598 /Source="Nicolas_S_feature" /locus_tag="new_4164565_4165231" /HighExp="LBGstat, C30, Cold, GM 10, GM 25, GM 15, GM-0.1, GM 45, GM 120, GM 90" /AntisenseName="yybT" /AntisenseCor="0.145393098609886" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1559" upshifts 3544932 /Source="Nicolas_upshifts" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3546026..3546955) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22956758; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391932.1" /db_xref="EnsemblGenomes-Gn:BSU40520" /db_xref="EnsemblGenomes-Tr:CAB16089" /db_xref="InterPro:IPR018710" /db_xref="SubtiList:BG10011" /db_xref="UniProtKB/Swiss-Prot:P37485" /translation="MKQTRALMEGAILISLFAIITLLVVYVPVIGTILLFALPLPMIL YTIRHGLKLGIWMGAVSLPVVFIVGSFNGLIVAFMSACAGIAMGHFFKRKEPGHAIIS GALIYMLSIVFYFVISIQFLGINIIDEAMTQYRQSLDIVETVAKQSGNAGQFEKQLKL MEEQLGIVQYLFPTAIVMVGVIFSFLSYLIAKPLLRRFSPDIPNLKPFRELKFPQSVV VLYLIIVMLSFLPLEKGQMLYSIALNGEFILGFLIFIQGLSFIFFYCHKKQYPKAAAV IAVILGFVHPVFMAAIRILGVLDMGFHIRNKVK*" /label="yybS CDS" gene complement(3546026..3546955) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /label="yybS gene" S_feature complement(3546956..3547092) /Source="Nicolas_S_feature" /locus_tag="new_4166589_4166725_c" /HighExp="H2O2, G150, G180, Cold, Paraq, G135, Oxctl, Salt, Etha, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1560" promotor_-10 complement(3547074..3547093) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3547092) /Source="Nicolas_upshifts" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3547108..3547113) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3547182..3547331) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097802.1" /db_xref="EnsemblGenomes-Gn:BSU40529" /db_xref="EnsemblGenomes-Tr:CAX52718" /db_xref="GOA:C0H3U2" /db_xref="UniProtKB/Swiss-Prot:C0H3U2" /translation="MWDMIKNFFLFSSGVLQATTLLLVILIFMYVRKTKKKNKESSGF MDDKH*" /label="yyzH CDS" gene complement(3547182..3547331) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /label="yyzH gene" downshifts complement(3547208) /Source="Nicolas_upshifts" /id="D2098" /incds=0 /nref=1 /ntot=44 /MaxReadThrough="6.98636" /MaxDrop="3.23568" /score="-6.7107279" /energy="-8.4" /TU="U3194" /idTUdmin="U3197" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3547370..3547389) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-10" upshifts complement(3547387) /Source="Nicolas_upshifts" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="upshifts" promotor_-35 complement(3547403..3547409) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-35" promotor_-35 3547410..3547419 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3547432..3547451 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3547438 /Source="Nicolas_upshifts" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3547450) /Source="Nicolas_upshifts" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3547452..3547965) /Source="Nicolas_S_feature" /locus_tag="new_4167085_4167598_c" /HighExp="dia5, Diami, H2O2, Salt, dia15, Etha, Paraq, LPhT, G180, C30" /AntisenseName="cotF" /AntisenseCor="-0.33406696665100499" /AntisenseRegPval="-7.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1561" promotor_-10 complement(3547454..3547468) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3547477..3547481) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3547477..3547959 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1708381, 19933362, 23335421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1708381, 19933362, 23335421; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_391933.1" /db_xref="EnsemblGenomes-Gn:BSU40530" /db_xref="EnsemblGenomes-Tr:CAB16090" /db_xref="GOA:P23261" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="InterPro:IPR016493" /db_xref="SubtiList:BG10012" /db_xref="UniProtKB/Swiss-Prot:P23261" /translation="MDERRTLAWHETLEMHELVAFQSNGLIKLKKMIREVKDPQLRQL YNVSIQGVEQNLRELLPFFPQAPHREDEEEERADNPFYSGDLLGFAKTSVRSYAIAIT ETATPQLRNVLVKQLNAAIQLHAQVYRYMYQHGYYPSYNLSELLKNDVRNANRAISMK *" /label="cotF CDS" gene 3547477..3547959 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /label="cotF gene" downshifts 3547946 /Source="Nicolas_upshifts" /id="D2099" /incds=0 /nref=20 /ntot=52 /MaxReadThrough="5.45774" /MaxDrop="4.1869" /score="-3.60126456" /energy="-16.9" /TU="U3195" /idTUdmin="U3195" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3547989..3548366) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22238377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22238377; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Cys-activated by oxidative stress)" /protein_id="NP_391934.1" /db_xref="EnsemblGenomes-Gn:BSU40540" /db_xref="EnsemblGenomes-Tr:CAB16091" /db_xref="GOA:P37486" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4A5M" /db_xref="PDB:4A5N" /db_xref="SubtiList:BG10013" /db_xref="UniProtKB/Swiss-Prot:P37486" /translation="MSEKKNIYPNKEGCPVEFTLDVIGGKWKGILFYHMIDGKKRFNE FRRICPSITQRMLTLQLRELEADGIVHREVYHQVPPKVEYSLTEFGRTLEPIVLQMKE WGESNRDVLESYRSNGLVKDQQK*" /label="hypR CDS" gene complement(3547989..3548366) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /label="hypR gene" S_feature 3547991..3548520 /Source="Nicolas_S_feature" /locus_tag="new_4167624_4168153" /HighExp="S8, S6, S7, BT, S5, B36, C30, B60, G/S, Pyr" /AntisenseName="yybR" /AntisenseCor="-0.26586375565089998" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1562" downshifts complement(3548010) /Source="Nicolas_upshifts" /id="D2100" /incds=0 /nref=124 /ntot=240 /MaxReadThrough="4.32896" /MaxDrop="5.38963" /score="10.6464065" /energy="-15.3" /TU="U3197" /idTUdmin="U3197" /TUdmin="-802" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3548421..3548440) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3548433) /Source="Nicolas_upshifts" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3548454..3548461) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3548502..3548506 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3548520..3548539 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3548522 /Source="Nicolas_upshifts" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3548547..3548561) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3548550) /Source="Nicolas_upshifts" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3548571..3549500 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /EC_number="3.6.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic pyrophosphatase (Mn2+-dependent)" /protein_id="NP_391935.1" /db_xref="EnsemblGenomes-Gn:BSU40550" /db_xref="EnsemblGenomes-Tr:CAB16092" /db_xref="GOA:P37487" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR004097" /db_xref="InterPro:IPR022934" /db_xref="PDB:1K23" /db_xref="PDB:1WPM" /db_xref="PDB:1WPN" /db_xref="PDB:2HAW" /db_xref="PDB:2IW4" /db_xref="SubtiList:BG10014" /db_xref="UniProtKB/Swiss-Prot:P37487" /translation="MEKILIFGHQNPDTDTICSAIAYADLKNKLGFNAEPVRLGQVNG ETQYALDYFKQESPRLVETAANEVNGVILVDHNERQQSIKDIEEVQVLEVIDHHRIAN FETAEPLYYRAEPVGCTATILNKMYKENNVKIEKEIAGLMLSAIISDSLLFKSPTCTD QDVAAAKELAEIAGVDAEEYGLNMLKAGADLSKKTVEELISLDAKEFTLGSKKVEIAQ VNTVDIEDVKKRQAELEAVISKVVAEKNLDLFLLVITDILENDSLALAIGNEAAKVEK AFNVTLENNTALLKGVVSRKKQVVPVLTDAMAE*" /label="ppaC CDS" gene 3548571..3549500 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /label="ppaC gene" downshifts 3549486 /Source="Nicolas_upshifts" /id="D2101" /incds=0 /nref=235 /ntot=270 /MaxReadThrough="2.06965" /MaxDrop="8.02492" /score="25.8885382" /energy="-11.7" /TU="NA" /idTUdmin="U3195" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 3549502..3549503 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_014" CDS complement(3549505..3550059) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /EC_number="2.3.1.79" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12731863, 12793527, 19087206, 22226636, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose O-acetyltransferase" /protein_id="NP_391965.1" /db_xref="EnsemblGenomes-Gn:BSU40850" /db_xref="EnsemblGenomes-Tr:CAB16122" /db_xref="GOA:P37515" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR024688" /db_xref="SubtiList:BG10043" /db_xref="UniProtKB/Swiss-Prot:P37515" /translation="MLRTEKEKMAAGELYNSEDQQLLLERKHARQLIRQYNETPEDDA VRTKLLKELLGSVGDQVTILPTFRCDYGYHIHIGDHTFVNFDCVILDVCEVRIGCHCL IAPGVHIYTAGHPLDPIERKSGKEFGKPVTIGDQVWIGGRAVINPGVTIGDNAVIASG SVVTKDVPANTVVGGNPARILKQL*" /label="maa CDS" gene complement(3549505..3550059) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /label="maa gene" CDS complement(3550077..3550457) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19087206; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_391966.1" /db_xref="EnsemblGenomes-Gn:BSU40860" /db_xref="EnsemblGenomes-Tr:CAB16123" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10044" /db_xref="UniProtKB/Swiss-Prot:P37516" /translation="MQIEHTAVWVNDLERMKSFYESYFNGEANDLYHNEKKDFKSYFI TFDSGARLEIMKKGNVTDPPSQTMTGWAHIAFSVGSREKVDELTDRLKADGFAVVNGP RTTGDGYYESVIEDDEGNLIEITI*" /label="yyaH CDS" gene complement(3550077..3550457) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /label="yyaH gene" CDS complement(3550513..3551448) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9457849, 9642180, 16267306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457849, 9642180, 16267306; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of carbon supply (LacIfamily)" /protein_id="NP_391967.1" /db_xref="EnsemblGenomes-Gn:BSU40870" /db_xref="EnsemblGenomes-Tr:CAB16124" /db_xref="GOA:P37517" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10045" /db_xref="UniProtKB/Swiss-Prot:P37517" /translation="MANIKEIARLANVSVSTVSRVLNHHPYVSEEKRKLVHQVMKELD YTPNRTAIDLIRGKTHTVGVILPYSDHPCFDKIVNGITKAAFQHEYATTLLPTNYNPD IEIKYLELLRTKKIDGLIITSRANHWDSILAYQEYGPVIACEDTGDIDVPCAFNDRKT AYAESFRYLKSRGHENIAFTCVREADRSPSTADKAAAYKAVCGRLEDRHMLSGCNDMN DGELAAEHFYMSGRVPTAIYANSDEVAAGIHLFAKKNNWDVEIIGEGNTSISRVLGFP SLDLNLEQLGIAAFSLFLQDEPADIKIQHKFKKKA*" /label="ccpB CDS" gene complement(3550513..3551448) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /label="ccpB gene" promotor_-35 3551438..3551447 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3551461..3551480 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3551468 /Source="Nicolas_upshifts" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3551492..3551511) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3551506) /Source="Nicolas_upshifts" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3551507..3552265) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /EC_number="3.1.11.2" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10540738, 16237020, 18203828, 21441501, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10540738, 16237020, 18203828, 21441501, 24244006, 24914186; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="apurinic/apyrimidinic endonuclease" /protein_id="NP_391968.1" /db_xref="EnsemblGenomes-Gn:BSU40880" /db_xref="EnsemblGenomes-Tr:CAB16125" /db_xref="GOA:P37454" /db_xref="InterPro:IPR004808" /db_xref="InterPro:IPR005135" /db_xref="InterPro:IPR020847" /db_xref="InterPro:IPR020848" /db_xref="InterPro:IPR036691" /db_xref="PDB:5CFE" /db_xref="SubtiList:BG10046" /db_xref="UniProtKB/Swiss-Prot:P37454" /translation="MKLISWNVNGLRAVMRKMDFLSYLKEEDADIICLQETKIQDGQV DLQPEDYHVYWNYAVKKGYSGTAVFSKQEPLQVIYGIGVEEHDQEGRVITLEFENVFV MTVYTPNSRRGLERIDYRMQWEEALLSYILELDQKKPVILCGDLNVAHQEIDLKNPKA NRNNAGFSDQEREAFTRFLEAGFVDSFRHVYPDLEGAYSWWSYRAGARDRNIGWRIDY FVVSESLKEQIEDASISADVMGSDHCPVELIINI*" /label="exoA CDS" gene complement(3551507..3552265) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /label="exoA gene" promotor_-35 complement(3551524..3551531) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3551798..3552301 /Source="Nicolas_S_feature" /locus_tag="new_4198071_4198574" /HighExp="C30, S8, S7, S6, BT, S5, M/G, Glucon, C90, T1.0H" /AntisenseName="exoAA" /AntisenseCor="-0.177921457862244" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1574" downshifts 3552260 /Source="Nicolas_upshifts" /id="D2118" /incds=0 /nref=2 /ntot=12 /MaxReadThrough="2.65789" /MaxDrop="4.11352" /score="16.4680636" /energy="-6.8" /TU="NA" /idTUdmin="U3224" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS complement(3552330..3552569) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 22720735, 24310371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 22720735, 24310371; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S18" /protein_id="NP_391969.2" /db_xref="EnsemblGenomes-Gn:BSU40890" /db_xref="EnsemblGenomes-Tr:CAB16126" /db_xref="GOA:P21475" /db_xref="InterPro:IPR001648" /db_xref="InterPro:IPR018275" /db_xref="InterPro:IPR036870" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10047" /db_xref="UniProtKB/Swiss-Prot:P21475" /translation="MAGGRRGGRAKRRKVCYFTSNGITHIDYKDVDLLKKFVSERGKI LPRRVTGTNAKYQRKLTAAIKRARQMALLPYVSGE*" /label="rpsR CDS" gene complement(3552330..3552569) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /label="rpsR gene" downshifts complement(3552336) /Source="Nicolas_upshifts" /id="D2119" /incds=0 /nref=217 /ntot=268 /MaxReadThrough="4.97781" /MaxDrop="7.46952" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227" /idTUdmin="U3229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3552404) /Source="Nicolas_upshifts" /id="D2120" /incds=1 /nref=13 /ntot=142 /MaxReadThrough="8.89363" /MaxDrop="3.9797" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227,U3229" /idTUdmin="U3229" /TUdmin="-68" /isTUend="FALSE" /label="downshifts" CDS complement(3552613..3553131) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391970.1" /db_xref="EnsemblGenomes-Gn:BSU40900" /db_xref="EnsemblGenomes-Tr:CAB16127" /db_xref="GOA:P37455" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10048" /db_xref="UniProtKB/Swiss-Prot:P37455" /translation="MLNRVVLVGRLTKDPELRYTPNGAAVATFTLAVNRTFTNQSGER EADFINCVTWRRQAENVANFLKKGSLAGVDGRLQTRNYENQQGQRVFVTEVQAESVQF LEPKNGGGSGSGGYNEGNSGGGQYFGGGQNDNPFGGNQNNQRRNQGNSFNDDPFANDG KPIDISDDDLPF*" /label="ssbA CDS" gene complement(3552613..3553131) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /label="ssbA gene" CDS complement(3553172..3553459) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 19653700, 26447183" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 19653700, 26447183; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S6 (BS9)" /protein_id="NP_391971.1" /db_xref="EnsemblGenomes-Gn:BSU40910" /db_xref="EnsemblGenomes-Tr:CAB16128" /db_xref="GOA:P21468" /db_xref="InterPro:IPR000529" /db_xref="InterPro:IPR014717" /db_xref="InterPro:IPR020814" /db_xref="InterPro:IPR020815" /db_xref="InterPro:IPR035980" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10049" /db_xref="UniProtKB/Swiss-Prot:P21468" /translation="MRKYEVMYIIRPNIDEESKKAVIERFNNVLTSNGAEITGTKDWG KRRLAYEINDFRDGFYQIVNVQSDAAAVQEFDRLAKISDDIIRHIVVKEEE*" /label="rpsF CDS" gene complement(3553172..3553459) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /label="rpsF gene" S_feature complement(3553460..3553526) /Source="Nicolas_S_feature" /locus_tag="new_4199733_4199799_c" /HighExp="MG t5, LPhT, GM 90, SMM, T-5.40H, GM-0.2, MG 150, GM 45, Gly, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.993, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1575" promotor_-10 complement(3553525..3553544) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3553526) /Source="Nicolas_upshifts" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3553558..3553563) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3553570..3554670) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12837776, 16014871, 18713637, 21527254, 22995830, 26018081, 26160547, 26912459; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent informational ATPase interacting with 70S ribosome; ROS stress regulator" /protein_id="NP_391972.1" /db_xref="EnsemblGenomes-Gn:BSU40920" /db_xref="EnsemblGenomes-Tr:CAB16129" /db_xref="GOA:P37518" /db_xref="InterPro:IPR004396" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR013029" /db_xref="InterPro:IPR023192" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="SubtiList:BG10050" /db_xref="UniProtKB/Swiss-Prot:P37518" /translation="MALTAGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGIV EVPDDRLQKLTELVNPKKTVPTAFEFTDIAGIVKGASKGEGLGNKFLSHIRQVDAICH VVRAFSDDNITHVSGKVDPIDDIETINLELILADMETVEKRITRVSKLAKQKDKDAVF EFEILSKLKEAFESEKPARSVEFTEEQQKLVKQLHLLTSKPILYVANVSEDEVADPSG NENVAKIREYAAGENAEVIVVCAKIESEIAELEGEEKQMFLEELGIQESGLDQLIKAS YSLLGLATYFTAGEQEVRAWTFKKGMKAPECAGIIHSDFERGFIRAETVAYEDLLAGG GMAGAKEAGKVRLEGKEYVVQDGDVIHFRFNV*" /label="engD CDS" gene complement(3553570..3554670) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /label="engD gene" promotor_-10 complement(3554718..3554737) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-10" upshifts complement(3554733) /Source="Nicolas_upshifts" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="upshifts" promotor_-35 complement(3554752..3554759) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-35" CDS complement(3554797..3556800) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /EC_number="1.-.-.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17114254, 20817769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (molybdoenzyme)" /protein_id="NP_391973.1" /db_xref="EnsemblGenomes-Gn:BSU40930" /db_xref="EnsemblGenomes-Tr:CAB16130" /db_xref="GOA:P37519" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG10051" /db_xref="UniProtKB/Swiss-Prot:P37519" /translation="MSKVHQSACPLNCWDSCGFLVTVDDGKVTKVDGDPNHPITEGKI CGRGRMLETKTNSPDRLRYPMKKQNGEFVRISWEQALDEIADKLREIKETSETTAVLH SHDYANNGLLKALDQRFFNGYGGVTEIVGSICWGSGIEAQSWDFGRSYGHGPLDIYNS KHVVVWGRNVSRTNMHLYHHLQQVKKKGATITVIDPIFNPTAKLADRYISVKPGMDGW LAAAVLKVLIEMGRTDETFISEHSVGFDDVKELLKTVSLEEFIVKTETSMEELEYLAG LYADGPVSTFMGLGMQRYKNGGGTIRWIDALVAASGNVGIKGGGANFGNVQIGESFAK TKLTLPELKTTSRSFSMMTQAEEVLTAADPAIEMIIVTCGNPLTQVPNTNKVRQAFEK VPMTVAIDSIMTDTAELCDYVLPTATVFEEEDIYYSSMYHHYVQYGKKLVEPQGEAKS DSWIWSELAKRLGFGELFEYSTQEFLEMGLSSLEAEDVTLERLKEKGHLPLPVKQVPW DDYQFLTPSGKFEFTSSLAEQKGFSGSLQLNVPEESVFHNEELAGKYPYTLLSIHPQR SNHSQHVPFIEKLQHVQVDISPDIAAGQDLQDGDEVVIFNDRGSMKGKVKVMKQAHAK TINIDEGMWAAFGGSVNALTNDTNSDNGMGSTLFDCLVGLKKA*" /label="yyaE CDS" gene complement(3554797..3556800) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /label="yyaE gene" CDS complement(3556851..3557057) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21348639, 22333191, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="YP_003097803.1" /db_xref="EnsemblGenomes-Gn:BSU40939" /db_xref="EnsemblGenomes-Tr:CAX52723" /db_xref="InterPro:IPR009296" /db_xref="UniProtKB/Swiss-Prot:C0H3V8" /translation="MADKDFGLNDIVEMKKPHPCGANSWKIIRMGMDIRIKCEGCSHS VMIPRREFERKLKKVLVKHEEPTS*" /label="yyzM CDS" gene complement(3556851..3557057) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /label="yyzM gene" promotor_-10 complement(3557019..3557038) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3557044) /Source="Nicolas_upshifts" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3557053..3557059) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3557083..3557102) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-10" upshifts complement(3557094) /Source="Nicolas_upshifts" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="upshifts" promotor_-35 complement(3557119..3557123) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-35" CDS complement(3557151..3558167) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16847258, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391974.1" /db_xref="EnsemblGenomes-Gn:BSU40940" /db_xref="EnsemblGenomes-Tr:CAB16131" /db_xref="SubtiList:BG10052" /db_xref="UniProtKB/Swiss-Prot:P37520" /translation="MLWRAGMKWMLLILGSLIGAGYASGQEIWQFFGAESGLAIVLFT IMFIFSSYIVMKISFKVQSTHFLPVLEHLMGPWLAKIYDVLIIFYLFSTTMVMIAGGG VTLQMYKLPFWWGITLICIVTVCLFLWDVKGILSINSILIPVLVAGLLYALISFQSTH HHTWTIDLSQQYNWPASITFTSLNILSVVAILSSVGKEMKGLGEAKIASVASGLIFGV ISFVYNETLVELAGSLSQFEIPLFAVLEGAPYFLFLCMTAVLCLAIYTTTVAGLLGLS SRLMAFIHMPRWMIVLILLVLMVPFTSFGFSDLIAFLYPIYGMLNLYLLVCLLLYPIL SKWK*" /label="yyaD CDS" gene complement(3557151..3558167) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /label="yyaD gene" promotor_-10 complement(3558200..3558218) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3558212) /Source="Nicolas_upshifts" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3558234..3558239) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3558343) /Source="Nicolas_upshifts" /id="D2121" /incds=0 /nref=32 /ntot=184 /MaxReadThrough="1.8976" /MaxDrop="3.72136" /score="9.09987016" /energy="-7.4" /TU="NA" /idTUdmin="U3230" /TUdmin="-397" /isTUend="FALSE" /label="downshifts" promotor_-35 3558527..3558532 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3558545..3558626 /Source="Nicolas_S_feature" /locus_tag="new_4204818_4204899" /HighExp="S4, S5, S3, S6, LoTm, S7, T5.0H, BT, M9-stat, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1576" upshifts 3558545 /Source="Nicolas_upshifts" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3558548..3558566 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3558627..3559244 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 26362088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore-specific protease" /protein_id="NP_391975.1" /db_xref="EnsemblGenomes-Gn:BSU40950" /db_xref="EnsemblGenomes-Tr:CAB16132" /db_xref="InterPro:IPR009665" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10053" /db_xref="UniProtKB/Swiss-Prot:P37521" /translation="MNRKGGLFSSQERVKQYVSHTDAAAAKQIQTILSSSLRKAAGKP IVVVCIGTDRSTGDSLGPLVGMKLKQMQLTRFHVYGTLSDPVHAVNMKDKINDIHKLH KNPFVIAVDACLGRVKSVGSFQIGDGPLKPGAGVQKDLPEVGDLHINGIVNVSGFMEY FVLQNTRLNLVMNMANVLAEGLSLTDRTEWRQERLNPLQRLTGRI*" /label="sprC CDS" gene 3558627..3559244 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /label="sprC gene" promotor_-35 3559215..3559223 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3559234 /Source="Nicolas_upshifts" /id="D2122" /incds=0 /nref=11 /ntot=30 /MaxReadThrough="2.64888" /MaxDrop="3.74502" /score="0.352922387" /energy="-6.6" /TU="NA" /idTUdmin="U3231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 3559237..3559255 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3559256 /Source="Nicolas_upshifts" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3559283..3560131) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103; Product type f: factor" /codon_start=1 /transl_table=11 /product="site-specific DNA-binding protein" /protein_id="NP_391976.1" /db_xref="EnsemblGenomes-Gn:BSU40960" /db_xref="EnsemblGenomes-Tr:CAB16133" /db_xref="GOA:P26497" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10054" /db_xref="UniProtKB/Swiss-Prot:P26497" /translation="MAKGLGKGINALFNQVDLSEETVEEIKIADLRPNPYQPRKHFDD EALAELKESVLQHGILQPLIVRKSLKGYDIVAGERRFRAAKLAGLDTVPAIVRELSEA LMREIALLENLQREDLSPLEEAQAYDSLLKHLDLTQEQLAKRLGKSRPHIANHLRLLT LPENIQQLIAEGTLSMGHGRTLLGLKNKNKLEPLVQKVIAEQLNVRQLEQLIQQLNQN VPRETKKKEPVKDAVLKERESYLQNYFGTTVNIKRQKKKGKIEIEFFSNEDLDRILEL LSERES*" /label="parB CDS" gene complement(3559283..3560131) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /label="parB gene" downshifts complement(3559303) /Source="Nicolas_upshifts" /id="D2123" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="3.01094" /MaxDrop="5.3801" /score="9.82080496" /energy="-7.9" /TU="U3233" /idTUdmin="U3233" /TUdmin="-257" /isTUend="FALSE" /label="downshifts" CDS complement(3560124..3560885) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome partitioning protein; transcriptionalregulator" /protein_id="NP_391977.1" /db_xref="EnsemblGenomes-Gn:BSU40970" /db_xref="EnsemblGenomes-Tr:CAB16134" /db_xref="GOA:P37522" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10055" /db_xref="UniProtKB/Swiss-Prot:P37522" /translation="MGKIIAITNQKGGVGKTTTSVNLGACLAYIGKRVLLVDIDPQGN ATSGLGIEKADVEQCVYDILVDDADVIDIIKATTVENLDVIPATIQLAGAEIELVPTI SREVRLKRALEAVKQNYDYIIIDCPPSLGLLTINALTASDSVVIPVQCEYYALEGLSQ LLNTVRLVQKHLNTDLMIEGVLLTMLDARTNLGIQVIEEVKKYFRDKVYKTVIPRNVR LSEAPSHGKPIILYDPRSRGAEVYLDLAKEVAANG*" /label="parA CDS" gene complement(3560124..3560885) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /label="parA gene" misc_feature complement(3560919..3560938) /Source="Nicolas_upshift_promotors" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3560937) /Source="Nicolas_upshifts" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3561029) /Source="Nicolas_upshifts" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="upshifts" promotor_-10 complement(3561032..3561040) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-10" promotor_-35 complement(3561054..3561062) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-35" promotor_-35 3561066..3561074 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3561082 /Source="Nicolas_upshifts" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3561086..3561104 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3561133..3561573 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25651892; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative antibiotic immunity protein" /protein_id="NP_391978.2" /db_xref="EnsemblGenomes-Gn:BSU40980" /db_xref="EnsemblGenomes-Tr:CAB16135" /db_xref="GOA:P37523" /db_xref="InterPro:IPR009589" /db_xref="SubtiList:BG10056" /db_xref="UniProtKB/Swiss-Prot:P37523" /translation="MVYQTKRDVPVTLMIVFLILLIQADAIVPFVLGNMRVSGWIIFI LLTLLNGLIIWSFIDLKYVLKEHHLIIKAGLIKHQIPYENIDKVVQKKKLWSGFRLIG SRHAITIYYQGGWGHAVISPQKSEEFIHKLKEKNSNIIIFTKSK*" /label="yyaB CDS" gene 3561133..3561573 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /label="yyaB gene" downshifts 3561522 /Source="Nicolas_upshifts" /id="D2124" /incds=0 /nref=3 /ntot=144 /MaxReadThrough="2.25356" /MaxDrop="3.41185" /score="-0.6683508" /energy="-14.5" /TU="NA" /idTUdmin="U3235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3561624..3562475) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /function="16.13: Shape" /function="16.8: Protect" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11807071, 15210112, 16549676, 25568309, 28500529" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807071, 15210112, 16549676, 25568309, 28500529; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-binding protein Spo0J-like" /protein_id="NP_391979.1" /db_xref="EnsemblGenomes-Gn:BSU40990" /db_xref="EnsemblGenomes-Tr:CAB16136" /db_xref="GOA:P37524" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR023705" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10057" /db_xref="UniProtKB/Swiss-Prot:P37524" /translation="MKHSFSRFFGLGEKEQEPEIAEHDTNKEEILEIPVNAIVPNRFQ PRTIFSDEKIKELAMTIHTHGIIQPIVVRHTEEEGQYELIAGERRWRAVQSLEWEKIP AIIKDFSDTETASVALIENLQREELSSIEEAHAYARLLELHDLTQEALAQRLGKGQST IANKLRLLKLPQPVQEAIMEKKITERHARALIPLKQPELQVTLLTEIIEKSLNVKQTE DRVVKMLEQGQRKPKPRRKAFSRDTRIAMNTIRQSLSMVEDSGVKLNTEEEEFEEYIQ LTIRIPK*" /label="nocA CDS" gene complement(3561624..3562475) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /label="nocA gene" downshifts complement(3561643) /Source="Nicolas_upshifts" /id="D2125" /incds=0 /nref=245 /ntot=265 /MaxReadThrough="2.30868" /MaxDrop="6.68899" /score="29.5496038" /energy="-14.5" /TU="NA" /idTUdmin="U3236" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(3562476..3562596) /Source="Nicolas_S_feature" /locus_tag="new_4208749_4208869_c" /HighExp="LBGstat, G135, G180, H2O2, dia15, G150, Paraq, T0.30H, Oxctl, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1577" CDS complement(3562597..3563316) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /EC_number="2.1.1.170" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12001236, 17238915, 17573471, 19622680, 24509311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12001236, 17238915, 17573471, 19622680, 24509311; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-methylguanosine methyltransferase (16S rRNA, nucleotide G527)" /protein_id="NP_391980.1" /db_xref="EnsemblGenomes-Gn:BSU41000" /db_xref="EnsemblGenomes-Tr:CAB16137" /db_xref="GOA:P25813" /db_xref="InterPro:IPR003682" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XDZ" /db_xref="SubtiList:BG10058" /db_xref="UniProtKB/Swiss-Prot:P25813" /translation="MNIEEFTSGLAEKGISLSPRQLEQFELYYDMLVEWNEKINLTSI TEKKEVYLKHFYDSITAAFYVDFNQVNTICDVGAGAGFPSLPIKICFPHLHVTIVDSL NKRITFLEKLSEALQLENTTFCHDRAETFGQRKDVRESYDIVTARAVARLSVLSELCL PLVKKNGLFVALKAASAEEELNAGKKAITTLGGELENIHSFKLPIEESDRNIMVIRKI KNTPKKYPRKPGTPNKSPIEG*" /label="rsmG CDS" gene complement(3562597..3563316) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /label="rsmG gene" CDS complement(3563330..3565216) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11914360, 14993678, 17062623, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA uridine 5-carboxymethylaminomethyl modification enzyme" /protein_id="NP_391981.1" /db_xref="EnsemblGenomes-Gn:BSU41010" /db_xref="EnsemblGenomes-Tr:CAB16138" /db_xref="GOA:P25812" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004416" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR026904" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10059" /db_xref="UniProtKB/Swiss-Prot:P25812" /translation="MGYEAGQYDVIVIGAGHAGVEAALASARQGAKTLVLTINLDMVA FMPCNPSVGGPAKGIVVREIDALGGEMGRNIDKTHIQMRMLNTGKGPAVRALRAQADK FQYQHEMKNTLEKEPNLTLLQGIVERLIVEDGECRGVITQTGAHYRAKAVVMTTGTYL RGRIILGDLSYSSGPNNQQPSIKLSEHLEELGFDLVRFKTGTPPRVKSDTIDYSKTEI QPGDDVPRAFSYETVEYITDQLPCWLTYTSPETHEIIDSNLHRSPMYSGMIKGTGPRY CPSIEDKVVRFNDKPRHQIFLEPEGRNTQEVYVQGLSTSLPEDVQQRMLATIPGLENV QMMRAGYAIEYDAIVPTQLWPTLETKKITNLYTAGQINGTSGYEEAAGQGIMAGINAG RKALGKEEVILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTE IGHRIGLISDERYAAFEKKKAAIEAEKKRLHSVIIKPSPENQEYIRSLGGSELKDGVR GTDLMKRPEMNYETVTKLAPPEVPVPQDVAEQVEIQVKYEGYIEKSLQQVEKLKKMEN KKIPDRIDYDAIKGIATEARQKLKNVRPLSVAQASRISGVNPADISILLVYLEQGRIA KIAE*" /label="trmF CDS" gene complement(3563330..3565216) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /label="trmF gene" CDS complement(3565237..3566616) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /EC_number="3.6.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15522079, 15616586, 19052377, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA modification GTPase and tRNA-U34 5-formylation enzyme" /protein_id="NP_391982.1" /db_xref="EnsemblGenomes-Gn:BSU41020" /db_xref="EnsemblGenomes-Tr:CAB16139" /db_xref="GOA:P25811" /db_xref="InterPro:IPR004520" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR018948" /db_xref="InterPro:IPR025867" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031168" /db_xref="SubtiList:BG10060" /db_xref="UniProtKB/Swiss-Prot:P25811" /translation="MDTIAAISTPMGEGAIAIVRLSGPEAIQIADKIYKGPKGKTLSS VESHTIHYGHIVDRPSDRVVEEVMVSVLKAPRTFTREDVIEINCHGGIVTVNQVLQLA LREGARLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAMNQMEGRLSALV RRLRSEILETLAHVEVNIDYPEYDDVEEMTHQILVEKATAVKKEIETLLRTSEQGKIL REGLSTVIIGRPNVGKSSLLNSLVHEAKAIVTDIPGTTRDVIEEYVNVRGVPLRLVDT AGIRETEDIVERIGVERSRQVLKEADLILLVLNYSEELSEEDVKLFEAVEGMDVIVIL NKTDLEPKIDTERVRELANGRPVVTTSLLKEEGINDLEEAIQSLFYTGAIESGDLTYV SNTRHITILQQAKRAIEDALSGIEQDVPIDMVQIDLTRCWELLGEIIGDSVHESLIDQ LFSQFCLGK*" /label="mnmE CDS" gene complement(3565237..3566616) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /label="mnmE gene" S_feature complement(3566617..3566747) /Source="Nicolas_S_feature" /locus_tag="new_4212890_4213020_c" /HighExp="dia15, Diami, LBGstat, H2O2, Paraq, dia5, G180, T0.30H, LBGexp, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1578" promotor_-10 complement(3566739..3566758) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3566747) /Source="Nicolas_upshifts" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3566774..3566778) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3566802..3566821) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-10" upshifts complement(3566812) /Source="Nicolas_upshifts" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="upshifts" promotor_-35 complement(3566835..3566842) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-35" promotor_-35 3566902..3566908 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3566913..3569198 /Source="Nicolas_S_feature" /locus_tag="new_4213186_4215471" /HighExp="T0.30H, C30, T1.0H, T1.30H, S2, T0.0H, T-1.10H, T-0.40H, T-1.40H, C90" /AntisenseName="oxaAA" /AntisenseCor="-0.20593684080740801" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.685" /TUlongSig="NA" /TUlongPSig="NA" /label="S1579" upshifts 3566913 /Source="Nicolas_upshifts" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3566923..3566942 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3566927..3567553) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1487728, 12813085, 26883633, 27776484; Product type f: factor" /codon_start=1 /transl_table=11 /product="SpoIIIJ-associated RNA/ssDNA-binding protein" /protein_id="NP_391983.1" /db_xref="EnsemblGenomes-Gn:BSU41030" /db_xref="EnsemblGenomes-Tr:CAB16140" /db_xref="GOA:Q01620" /db_xref="InterPro:IPR001374" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR032782" /db_xref="InterPro:IPR034079" /db_xref="InterPro:IPR036867" /db_xref="SubtiList:BG10061" /db_xref="UniProtKB/Swiss-Prot:Q01620" /translation="MRNVTAAGRNVDEAVQSGLQELGLTKDKVEITVIEEGNKGFLGI FGKKPAIVKLVEKIDPIQQAKLYLQTIAEAIAGKSDVTVQESKKTVRYHITGEKAALL IGKRGQTLNALETLTQLALNRYPGQYKNVTVDAENYRLKRKETLSQLAIKLADQVLKT KKSIQLEPMPSSERKIIHDTLSGYANHQIKTYSMGEGENRHLVISHKR*" /label="jag CDS" gene complement(3566927..3567553) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /label="jag gene" downshifts complement(3566944) /Source="Nicolas_upshifts" /id="D2126" /incds=0 /nref=229 /ntot=258 /MaxReadThrough="2.29192" /MaxDrop="6.32351" /score="24.2602773" /energy="-14.1" /TU="NA" /idTUdmin="U3239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3567550..3568335) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_391984.1" /db_xref="EnsemblGenomes-Gn:BSU41040" /db_xref="EnsemblGenomes-Tr:CAB16141" /db_xref="GOA:Q01625" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG10062" /db_xref="UniProtKB/Swiss-Prot:Q01625" /translation="MLLKRRIGLLLSMVGVFMLLAGCSSVKEPITADSPHFWDKYVVY PLSELITYVAKLTGDNYGLSIILVTILIRLLILPLMIKQLRSSKAMQALQPEMQKLKE KYSSKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEH SFLWFDLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAI NFPAALSLYWVVGNLFMIAQTFLIKGPDIKKNPEPQKAGGKKK*" /label="oxaAA CDS" gene complement(3567550..3568335) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /label="oxaAA gene" promotor_-10 complement(3568380..3568399) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3568392) /Source="Nicolas_upshifts" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3568394..3568479) /Source="Nicolas_S_feature" /locus_tag="new_4214667_4214752_c" /HighExp="G135, G180, H2O2, Oxctl, Paraq, G150, Cold, LPh, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1580" promotor_-35 complement(3568411..3568417) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3568480..3568830) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /EC_number="3.1.26.5" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16061811, 16163391, 16980484, 17299131, 21347352, 24580115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein component of ribonuclease P (RNase P) (substrate specificity)" /protein_id="NP_391985.1" /db_xref="EnsemblGenomes-Gn:BSU41050" /db_xref="EnsemblGenomes-Tr:CAB16142" /db_xref="GOA:P25814" /db_xref="InterPro:IPR000100" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020539" /db_xref="InterPro:IPR020568" /db_xref="PDB:1A6F" /db_xref="PDB:4JG4" /db_xref="SubtiList:BG10063" /db_xref="UniProtKB/Swiss-Prot:P25814" /translation="MKKRNRLKKNEDFQKVFKHGTSVANRQFVLYTLDQPENDELRVG LSVSKKIGNAVMRNRIKRLIRQAFLEEKERLKEKDYIIIARKPASQLTYEETKKSLQH LFRKSSLYKKSSSK*" /label="rnpA CDS" gene complement(3568480..3568830) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /label="rnpA gene" S_feature complement(3568831..3568981) /Source="Nicolas_S_feature" /locus_tag="new_4215104_4215254_c" /HighExp="G135, G180, Oxctl, H2O2, Paraq, Cold, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1581" CDS complement(3568982..3569116) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7539334, 9371771, 12682299, 23002217, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7539334, 9371771, 12682299, 23002217, 25182490; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L34" /protein_id="NP_391986.1" /db_xref="EnsemblGenomes-Gn:BSU41060" /db_xref="EnsemblGenomes-Tr:CAB16143" /db_xref="GOA:P05647" /db_xref="InterPro:IPR000271" /db_xref="InterPro:IPR020939" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10064" /db_xref="UniProtKB/Swiss-Prot:P05647" /translation="MKRTFQPNNRKRSKVHGFRSRMSSKNGRLVLARRRRKGRKVLSA *" /label="rpmH CDS" gene complement(3568982..3569116) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /label="rpmH gene" promotor_no_box 3569140..3569240 /Source="Nicolas_upshift_promotors" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(3569152..3569171) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3569162) /Source="Nicolas_upshifts" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3569164..3569232) /Source="Nicolas_S_feature" /locus_tag="new_4215437_4215505_c" /HighExp="Oxctl, G180, Paraq, H2O2, LBGstat, GM 120, MG-0.2, HPh, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1582" promotor_-35 complement(3569187..3569194) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3569200..>3569333 /Source="Nicolas_S_feature" /locus_tag="new_4215473_4215670" /HighExp="T0.30H, C30, T1.0H, T1.30H, T0.0H, T-0.40H, S2, T-1.10H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.048" /TUlongSig="NA" /TUlongPSig="NA" /label="S1583" upshifts 3569200 /Source="Nicolas_upshifts" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3569218..3569237) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3569232) /Source="Nicolas_upshifts" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3569253..3569257) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3569334..3569481 /locus_tag="new_1_148" /created_by="stephanmichalik" /label="S1" S_feature complement(3569357..3569630) /locus_tag="new_24_297_c" /created_by="stephanmichalik" /label="S2" S_feature 3569483..3569742 /locus_tag="new_150_409" /created_by="stephanmichalik" /label="S3" ORIGIN 1 atggaaaata tattagacct gtggaaccaa gcccttgctc aaatcgaaaa aaagttgagc 61 aaaccgagtt ttgagacttg gatgaagtca accaaagccc actcactgca aggcgataca 121 ttaacaatca cggctcccaa tgaatttgcc agagactggc tggagtccag atacttgcat 181 ctgattgcag atactatata tgaattaacc ggggaagaat tgagcattaa gtttgtcatt 241 cctcaaaatc aagatgttga ggactttatg ccgaaaccgc aagtcaaaaa agcggtcaaa 301 gaagatacat ctgattttcc tcaaaatatg ctcaatccaa aatatacttt tgatactttt 361 gtcatcggat ctggaaaccg atttgcacat gctgcttccc tcgcagtagc ggaagcgccc 421 gcgaaagctt acaacccttt atttatctat gggggcgtcg gcttagggaa aacacactta 481 atgcatgcga tcggccatta tgtaatagat cataatcctt ctgccaaagt ggtttatctg 541 tcttctgaga aatttacaaa cgaattcatc aactctatcc gagataataa agccgtcgac 601 ttccgcaatc gctatcgaaa tgttgatgtg cttttgatag atgatattca atttttagcg 661 gggaaagaac aaacccagga agaatttttc catacattta acacattaca cgaagaaagc 721 aaacaaatcg tcatttcaag tgaccggccg ccaaaggaaa ttccgacact tgaagacaga 781 ttgcgctcac gttttgaatg gggacttatt acagatatca caccgcctga tctagaaacg 841 agaattgcaa ttttaagaaa aaaggccaaa gcagagggcc tcgatattcc gaacgaggtt 901 atgctttaca tcgcgaatca aatcgacagc aatattcggg aactcgaagg agcattaatc 961 agagttgtcg cttattcatc tttaattaat aaagatatta atgctgatct ggccgctgag 1021 gcgttgaaag atattattcc ttcctcaaaa ccgaaagtca ttacgataaa agaaattcag 1081 agggtagtag gccagcaatt taatattaaa ctcgaggatt tcaaagcaaa aaaacggaca 1141 aagtcagtag cttttccgcg tcaaatcgcc atgtacttat caagggaaat gactgattcc 1201 tctcttccta aaatcggtga agagtttgga ggacgtgatc atacgaccgt tattcatgcg 1261 catgaaaaaa tttcaaaact gctggcagat gatgaacagc ttcagcagca tgtaaaagaa 1321 attaaagaac agcttaaata gcaggaccgg ggatcaatcg gggaaagtgt gaataacttt 1381 tcggaagtca tacacagtct gtccacatgt ggataggctg tgtttcctgt ctttttcaca 1441 acttatccac aaatccacag gccctactat tacttctact attttttata aatatatata 1501 ttaatacatt atccgttagg aggataaaaa tgaaattcac gattcaaaaa gatcgtcttg 1561 ttgaaagtgt ccaagatgta ttaaaagcag tttcatccag aaccacgatt cccattctga 1621 ctggtattaa aattgttgca tcagatgatg gagtatcctt tacagggagt gactcagata 1681 tttctattga atccttcatt ccaaaagaag aaggagataa agaaatcgtc actattgaac 1741 agcccggaag catcgtttta caggctcgct tttttagtga aattgtaaaa aaattgccga 1801 tggcaactgt agaaattgaa gtccaaaatc agtatttgac gattatccgt tctggtaaag 1861 ctgaatttaa tctaaacgga ctggatgctg atgaatatcc gcacttgccg cagattgaag 1921 agcatcatgc gattcagatc ccaactgatt tgttaaaaaa tctaatcaga caaacagtat 1981 ttgcagtgtc cacctcagaa acacgcccta tcttgacagg tgtaaactgg aaagtggagc 2041 aaagtgaatt attatgcact gcaacggata gccaccgtct tgcattaaga aaggcgaaac 2101 ttgatattcc agaagacaga tcttataacg tcgtgattcc gggaaaaagt ttaactgaac 2161 tcagcaagat tttagatgac aaccaggaac ttgtagatat cgtcatcaca gaaacccaag 2221 ttctgtttaa agcgaaaaac gtcttgttct tctcacggct tctggacggg aattatccag 2281 acacaaccag cctgattccg caagacagca aaacagaaat cattgtgaac acaaaagaat 2341 tccttcaggc cattgatcgt gcatctcttt tagctagaga gggacgcaac aacgttgtaa 2401 aactgtccgc aaaaccggct gaatccattg aaatttcttc caattcgcca gaaatcggta 2461 aagttgtgga agcaattgtt gcggatcaaa ttgaaggtga ggaattaaat atctctttta 2521 gtccaaaata tatgctggat gcactaaagg tgcttgaagg agcagaaata cgcgtaagct 2581 ttacaggcgc aatgagacct ttcttaattc gcacgccgaa tgatgaaacg attgtacagc 2641 ttatccttcc tgtcagaacc tattaatccg atacactgct gccgacccgt cggcagcttt 2701 tctattcggt atctgctccg acaagttttc cctttcccta attcgttttt ttttagtaca 2761 attagatatt agtgatattt gaaagaggtc gatataatgg caaatccgat ttcaattgat 2821 acagagatga ttacactcgg acaattctta aaattagccg atgtgattca gtctggcggt 2881 atggcgaagt ggtttttaag cgagcatgaa gtgcttgtga acgatgagcc ggacaaccgc 2941 cggggcagaa agctgtatgt tggagatgtg gtagagattg aaggatttgg ttcatttcaa 3001 gtcgtcaatt aaagcgggtg acactgattg tatatccaga acttagaact gacatcttac 3061 cgcaactacg accatgctga acttcaattt gaaaataaag taaatgtgat catcggagaa 3121 aacgcccagg ggaagacaaa cctcatggag gcgatctatg tcttgtccat ggcgaaatcg 3181 caccggacat caaatgacaa agaacttata cggtgggaca aagactatgc taaaatagag 3241 ggaagagtga tgaagcaaaa cggggcgatc ccgatgcagc tcgtcatctc caaaaagggt 3301 aaaaagggca aggtcaatca tattgaacag caaaagctca gccagtatgt cggggccctc 3361 aacaccatta tgttcgcgcc ggaagattta aatcttgtaa agggaagccc tcaagtgaga 3421 aggcggtttc ttgacatgga aatcggacag gtttctcccg tctaccttca tgatctttct 3481 ctttaccaga aaatcctttc ccagcggaat cattttttga aacagctgca aacaagaaaa 3541 caaactgacc ggacgatgct cgatgttctg accgatcagc ttgtagaagt tgcagcaaaa 3601 gtcgtcgtaa aacgcctgca gtttacagca cagctcgaga aatgggcgca gcccatccat 3661 gcaggcatct caagagggct tgaagaactg accctgaaat accatacagc tcttgatgta 3721 tcagatcccc tagatttgtc gaaaatagga gatagctatc aagaagcgtt ttctaaatta 3781 agagaaaaag aaattgagcg tggtgtgacg ctgtcagggc ctcatcgcga tgatgttctt 3841 ttctatgtga acggacgcga tgtgcagacg tatggttctc aaggacagca gcgaacgacg 3901 gcgttgtccc ttaagctggc ggagattgac ctgatccatg aagaaatcgg agaatatccc 3961 attttactat tggatgatgt actgagtgaa ctggatgatt atcgccagtc acacttgctt 4021 catacgatcc aaggccgtgt acaaacgttt gtcacaacga caagcgttga tggcattgat 4081 cacgaaacct tacgtcaagc aggaatgttc cgtgtgcaaa atggtgcgtt agtgaagtga 4141 agaaatgagg tgagcaattg tatattcatt taggtgatga ctttgtggtt tcaacacgag 4201 atattgtcgg catttttgac tttaaagcca acatgtcgcc tattgttgaa gaatttctga 4261 aaaaacagaa acacaaggtg gtgccttccg taaacggcac gcccaaatct atcgtagtca 4321 cggttcagaa tatatattac tctcccttat cttccagcac attaaaaaaa cgtgcgcaat 4381 ttatgtttga aatagattct tagaaatttt ttatcacgaa tatatcgttt agaaaagtgt 4441 aggtgaatga cgtggctatg gaacagcagc aaaacagtta tgatgaaaat cagatacagg 4501 tactagaagg attggaagct gttcgtaaaa gaccggggat gtatatcggt tcgacaaaca 4561 gcaaaggcct tcaccacttg gtatgggaaa ttgtcgacaa tagtattgac gaagccctcg 4621 ccggttattg tacggatatc aatatccaaa tcgaaaaaga caacagtatc acggttgtag 4681 ataatggccg cggtattcca gtcggtattc atgaaaaaat gggccgtcct gcggtagaag 4741 tcattatgac ggtgcttcat gccggaggaa aatttgacgg aagcggctat aaagtatccg 4801 gaggattaca cggtgtaggt gcgtcggtcg taaacgcact atcaacagag cttgatgtga 4861 cggttcaccg tgacggtaaa attcaccgcc aaacctataa acgcggagtt ccggttacag 4921 accttgaaat cattggcgaa acggatcata caggaacgac gacacatttt gtcccggacc 4981 ctgaaatttt ctcagaaaca accgagtatg attacgatct gcttgccaac cgcgtgcgtg 5041 aattagcctt tttaacaaag ggcgtaaaca tcacgattga agataaacgt gaaggacaag 5101 agcgcaaaaa tgaataccat tacgaaggcg gaattaaaag ttatgtagag tatttaaacc 5161 gctctaaaga ggttgtccat gaagagccga tttacattga aggcgaaaag gacggcatta 5221 cggttgaagt ggctttgcaa tacaatgaca gctacacaag caacatttac tcgtttacaa 5281 acaacattaa cacgtacgaa ggcggtaccc atgaagctgg cttcaaaacg ggcctgactc 5341 gtgttatcaa cgattacgcc agaaaaaaag ggcttattaa agaaaatgat ccaaacctaa 5401 gcggagatga cgtaagggaa gggctgacag cgattatttc aatcaaacac cctgatccgc 5461 agtttgaggg ccaaacaaaa acaaagctgg gcaactcaga agcacggacg atcaccgata 5521 cgttattttc tacggcgatg gaaacattta tgctggaaaa tccagatgca gccaaaaaaa 5581 ttgtcgataa aggtttaatg gcggcaagag caagaatggc tgcgaaaaaa gcgcgtgaac 5641 taacacgccg taagagtgct ttggaaattt caaacctgcc cggtaagtta gcggactgct 5701 cttcaaaaga tccgagcatc tccgagttat atatcgtaga gggtgactct gccggaggat 5761 ctgctaaaca aggacgcgac agacatttcc aagccatttt gccgcttaga ggtaaaatcc 5821 taaacgttga aaaggccaga ctggataaaa tcctttctaa caacgaagtt cgctctatga 5881 tcacagcgct cggcacaggt atcggagaag acttcaacct tgagaaagcc cgttaccaca 5941 aagttgtcat tatgacagat gccgatgttg acggcgcgca catcagaaca ctgctgttaa 6001 cgttctttta cagatatatg cgccaaatta tcgaaaatgg ctacgtgtac attgcgcagc 6061 cgccgctcta caaggttcaa caggggaaac gcgttgaata tgcatacaat gacaaggagc 6121 ttgaagagct gttaaaaact cttcctcaaa cgcctaagcc tggactgcag cgttacaaag 6181 gtcttggtga aatgaatgcc acccagctat gggagacaac catggatcct agctccagaa 6241 cacttcttca ggtaactctt gaagatgcaa tggatgcgga tgagactttt gaaatgctta 6301 tgggcgacaa ggtagaaccg cgccgaaact tcatagaagc gaatgcgaga tacgttaaaa 6361 atcttgacat ctaatcataa aaagccttat ttccaataag aaataaggct tttttctgaa 6421 caagatcaga tgcagcgatg cctgcaatac ctatatattc tagcaattta atgtgtataa 6481 tcataagttt attgatataa tggagaatag tgaaatcgta ttgaaggtca taatggacaa 6541 tctactccca catatttcat gtgatacttc agggaggttt tttaatgagt gaacaaaaca 6601 caccacaagt tcgtgaaata aatatcagtc aggaaatgcg tacgtccttc ttggattatg 6661 caatgagcgt tatcgtgtcc cgtgctcttc cggatgttcg tgacggttta aaaccggttc 6721 atagacggat tttgtatgca atgaatgatt taggcatgac aagtgacaag ccttataaaa 6781 aatccgcgcg tatcgttgga gaagttatcg ggaaatacca cccgcacggt gattcagcgg 6841 tatatgaatc catggtcaga atggctcagg atttcaacta ccgttatatg ctcgttgacg 6901 gtcacggaaa cttcggttct gttgacggag actcagcggc ggccatgcgt tatacagaag 6961 cacgaatgtc taaaatctca atggagattc ttcgcgacat cacaaaagac acaatcgatt 7021 accaggataa ctatgacggg tcagaaagag aacctgtcgt tatgccttca aggttcccga 7081 atctgctcgt gaacggtgct gccggcattg cggtaggtat ggcaacaaac attcctccgc 7141 accagctggg agaaatcatt gacggtgtac ttgctgttag tgagaatccg gacattacaa 7201 ttccagagct tatggaagtc attccagggc ctgatttccc gaccgcgggt caaatcttgg 7261 gacgcagcgg tatccggaaa gcatacgaat caggccgagg ctctatcacg atccgggcaa 7321 aagctgagat cgaacaaaca tcttcgggta aagaaagaat tatcgttaca gagttacctt 7381 accaagtaaa taaggcgaaa ttaattgaga aaattgctga tctcgtaagg gacaaaaaga 7441 tagagggtat cacagatctg cgtgatgagt cagatcgtac aggtatgaga attgtcattg 7501 aaatcagacg cgatgccaat gcgaatgtta tcttaaacaa tctgtacaaa caaactgctc 7561 tacaaacatc ttttggcatc aacctgcttg cgcttgttga tggccagccg aaagttttaa 7621 ctcttaagca atgcctggag cattaccttg accatcaaaa agttgtcatt agacgccgta 7681 ctgcttatga attgcgtaaa gcagaagcga gagctcatat cttggaagga ttgagagttg 7741 cactggatca tctcgatgca gttatctccc ttatccgtaa ttctcaaacg gctgaaattg 7801 cgagaacagg tttaattgaa caattctcac tgacagagaa gcaagcacaa gcgatccttg 7861 acatgaggct ccagcgttta acgggactgg aacgtgaaaa gatcgaagaa gaataccagt 7921 ctcttgttaa attaattgca gagctaaaag acatcttggc aaatgaatat aaagtgcttg 7981 agatcattcg tgaagaactc acggaaatca aagagcgttt taacgatgaa agacgtactg 8041 agatcgtcac ttctggactg gagacaattg aagatgaaga tctcatcgag agagaaaata 8101 tcgtagttac tctgacgcac aacggatacg tcaaacgtct tcctgcatca acttaccgca 8161 gtcaaaaacg gggcggaaaa ggtgtacaag gtatgggaac aaacgaagat gatttcgttg 8221 aacatttgat ctctacgtca actcatgaca cgattctctt cttctcgaac aaggggaaag 8281 tgtatcgtgc aaaagggtat gaaatccctg aatacggcag aacggcaaaa ggaatcccga 8341 ttattaacct gctggaggta gaaaagggtg agtggatcaa cgcgattatt ccagtcacgg 8401 aattcaatgc ggagctttac ctcttcttca ctacaaagca tggggtttca aaacgaacat 8461 cgctatctca attcgctaat atccgcaaca atggtctaat tgctctgagt cttcgtgaag 8521 atgatgaact gatgggtgta cgtctgactg acggcacaaa acaaatcatc attggaacga 8581 aaaacggttt actgattcgt ttccctgaaa cagatgtccg agagatggga agaactgcgg 8641 cgggcgtaaa aggcatcacc ctgacggatg acgacgttgt tgtcggcatg gagattttag 8701 aggaagaatc acacgtcctt atcgtaactg aaaaagggta cggaaaacga actcctgctg 8761 aagagtacag aacccaaagc cggggcggaa aaggactcaa aacagcgaaa atcaccgaga 8821 acaacggcca actagtagca gtgaaagcta ctaaaggtga agaggatcta atgattatta 8881 cagctagcgg cgtactcatc agaatggaca tcaatgatat ctccatcacc ggacgtgtca 8941 ctcaaggtgt gcgtctcatc agaatggcag aagaagagca tgttgctaca gtagctttag 9001 ttgagaaaaa cgaagaagat gagaatgaag aagaacaaga agaagtgtga aaaaaagcgc 9061 agctgaaata gctgcgcttt tttgtgtcat aaccctttac agtcataaaa attatggtat 9121 aatcatttct gttgtctttt taaagacaca agcatgacca ttatgactag taaaaacttt 9181 ttcaaaaaag tattgaccta gttaactaaa aatgttacta ttaagtagtc gctttgagag 9241 aagcacacaa agttctttga aaactaaaca agacaaaacg tacctgttaa ttcattttta 9301 taaatcgcac agcgatgtgc gtagtcagtc aaactagggc ctgcacgacg caggtcacac 9361 aggtgtcgcc gcaggatgcg gtgaacttaa cctgtgatcc atttatcgga gagtttgatc 9421 ctggctcagg acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg gacagatggg 9481 agcttgctcc ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa 9541 gactgggata actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt 9601 caaacataaa aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt 9661 tggtgaggta acggctcacc aaggcgacga tgcgtagccg acctgagagg gtgatcggcc 9721 acactgggac tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc 9781 aatggacgaa agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa 9841 gctctgttgt tagggaagaa caagtgccgt tcgaataggg cggtaccttg acggtaccta 9901 accagaaagc cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt 9961 tgtccggaat tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc 10021 ccccggctca accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag 10081 tggaattcca cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg 10141 cgactctctg gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag 10201 ataccctggt agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct 10261 tagtgctgca gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac 10321 tcaaaggaat tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac 10381 gcgaagaacc ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt 10441 cgggggcaga gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt 10501 taagtcccgc aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta 10561 aggtgactgc cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct 10621 tatgacctgg gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg 10681 ttaagccaat cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg 10741 aagctggaat cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt 10801 gtacacaccg cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt 10861 ttaggagcca gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc 10921 gtatcggaag gtgcggctgg atcacctcct ttctaaggat attttacgga atataagacc 10981 ttgggtctta taaacagaac gttccctgtc ttgtttagtt ttgaaggaac tttgttcctt 11041 gaataagtta agatgggcct gtagctcagc tggttagagc gcacgcctga taagcgtgag 11101 gtcggtggtt cgagtccact caggcccacc atcttatata acggggcctt agctcagctg 11161 ggagagcgcc tgctttgcac gcaggaggtc agcggttcga tcccgctagg ctccaccaac 11221 gtgttctttg aaaactagat aacagtagac atcacattca attagtaaca caagatatca 11281 catagtgatt ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta 11341 ggagccgatg aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg 11401 atccggagat ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga 11461 attcatagga tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag 11521 agaaagcaaa tgcgattccc tgagtagcgg cgagcgaaac gggatcagcc caaaccaaga 11581 ggcttgcctc ttggggttgt aggacactct gtacggagtt acaaaggaac gaggtagatg 11641 aagaggtctg gaaaggcccg ccataggagg taacagccct gtagtcaaaa cttcgttctc 11701 tcctgagtgg atcctgagta cggcggaaca cgtgaaattc cgtcggaatc cgggaggacc 11761 atctcccaag gctaaatact ccctagtgac cgatagtgaa ccagtaccgt gagggaaagg 11821 tgaaaagcac cccggaaggg gagtgaaaga gatcctgaaa ccgtgtgcct acaagtagtc 11881 agagcccgtt aacgggtgat ggcgtgcctt ttgtagaatg aaccggcgag ttacgatctc 11941 gtgcaaggtt aagcagaaga tgcggagccg cagcgaaagc gagtctgaat agggcgcatg 12001 agtacgtggt cgtagacccg aaaccaggtg atctacccat gtccagggtg aagttcaggt 12061 aacactgaat ggaggcccga acccacgcac gttgaaaagt gcggggatga ggtgtgggta 12121 ggggtgaaat gccaatcgaa cctggagata gctggttctc tccgaaatag ctttagggct 12181 agcctcaagg taagagtctt ggaggtagag cactgattgg actaggggcc cctaccgggt 12241 taccgaattc agtcaaactc cgaatgccaa tgacttatcc ttgggagtca gactgcgagt 12301 gataagatcc gtagtcgaaa gggaaacagc ccagaccgcc agctaaggtc ccaaagtata 12361 cgttaagtgg aaaaggatgt ggagttgctt agacaaccag gatgttggct tagaagcagc 12421 caccatttaa agagtgcgta atagctcact ggtcgagtga ctctgcgccg aaaatgtacc 12481 ggggctaaac gtatcaccga agctgcggac tgttcttcga acagtggtag gagagcgttc 12541 taagggctgt gaagccagac cggaaggact ggtggagcgc ttagaagtga gaatgccggt 12601 atgagtagcg aaagaggggt gagaatcccc tccaccgaat gcctaaggtt tcctgaggaa 12661 ggctcgtccg ctcagggtta gtcgggacct aagccgaggc cgaaaggcgt aggcgatgga 12721 caacaggttg atattcctgt accacctcct caccatttga gcaatggggg gacgcaggag 12781 gatagggtaa gcgcggtatt ggatatccgc gtccaagcag ttaggctggg aaataggcaa 12841 atccgtttcc cataaggctg agctgtgatg gcgagcgaaa tatagtagcg aagttcctga 12901 ttccacactg ccaagaaaag cctctagcga ggtgagaggt gcccgtaccg caaaccgaca 12961 caggtaggcg aggagagaat cctaaggtga tcgagagaac tctcgttaag gaactcggca 13021 aaatgacccc gtaacttcgg gagaaggggt gctctgttag ggtgcaagcc cgagagagcc 13081 gcagtgaata ggcccaggcg actgtttagc aaaaacacag gtctctgcga agccgtaagg 13141 cgaagtatag gggctgacgc ctgcccggtg ctggaaggtt aagaggagcg cttagcgtaa 13201 gcgaaggtgc gaattgaagc cccagtaaac ggcggccgta actataacgg tcctaaggta 13261 gcgaaattcc ttgtcgggta agttccgacc cgcacgaaag gcgcaacgat ctgggcactg 13321 tctcaacgag agactcggtg aaattatagt acctgtgaag atgcaggtta cccgcgacag 13381 gacggaaaga ccccgtggag ctttactgca gcctgatatt gaatgttggt acagcttgta 13441 caggataggt aggagccttg gaaaccggag cgccagcttc ggtggaggca tcggtgggat 13501 actaccctgg ctgtattgac cttctaaccc gccgccctta tcgggcgggg agacagtgtc 13561 aggtgggcag tttgactggg gcggtcgcct cctaaaaggt aacggaggcg cccaaaggtt 13621 ccctcagaat ggttggaaat cattcgcaga gtgtaaaggc acaagggagc ttgactgcga 13681 gacctacaag tcgagcaggg acgaaagtcg ggcttagtga tccggtggtt ccgcatggaa 13741 gggccatcgc tcaacggata aaagctaccc cggggataac aggcttatct cccccaagag 13801 tccacatcga cggggaggtt tggcacctcg atgtcggctc atcgcatcct ggggctgtag 13861 tcggtcccaa gggttgggct gttcgcccat taaagcggta cgcgagctgg gttcagaacg 13921 tcgtgagaca gttcggtccc tatccgtcgc gggcgcagga aatttgagag gagctgtcct 13981 tagtacgaga ggaccgggat ggacgcaccg ctggtgtacc agttgttctg ccaagggcat 14041 cgctgggtag ctatgtgcgg acgggataag tgctgaaagc atctaagcat gaagcccccc 14101 tcaagatgag atttcccatt ccgcaaggaa gtaagatccc tgaaagatga tcaggttgat 14161 aggtctgagg tggaagtgtg gcgacacatg gagctgacag atactaatcg atcgaggact 14221 taaccatatt tttgaatgat gtcacacctg ttatctagtt ttgagagaac actctcaatt 14281 tgtttggtgg cgatagcgaa gaggtcacac ccgttcccat accgaacacg gaagttaagc 14341 tcttcagcgc cgatggtagt cgggggtttc cccctgtgag agtaggacgc cgccaagcaa 14401 gcttaaaccc agctcaatga gctgggtttt ttgtttgtta aaaatgaaga agaaactgtg 14461 aagcgtattt agggaatttc ttttctgata ctaataaaaa ctgctgaatt aacacgtagt 14521 catcacttat atgctgtgtt aataactcat accaccattc tgtttcatac cttgcaatca 14581 tcccaacgtt gtacaaaatc aaataatgaa ttgtcatttc gggaagcctc agaaattgct 14641 ccctttgaga agggatataa tattggttct tttccatgtc aaacaataag ctggtcgatg 14701 tccatggctc cttgtcttgt ggtgaaattt cgaacagcag cccgtgttca tttttttttg 14761 taaaagacca ttgataatga tgggacatgt attcagcaaa ccttgaatca gacattttgt 14821 aattgattac tacttcctcc ggtacaaaaa tttcgttctt atccttctca acttttgtca 14881 taaatcgttc tttctgctga aagtagaaaa tatcgctaag ttctggaatg gccattaata 14941 attttttcat ggtataccgt tcatctacta tatccgattg tccgaataaa tgtttcataa 15001 aatgtacgca taggccattc cgttgtattt tcacttcatc gtcgctaaaa caataatttt 15061 gtttctttcg ttttcttgtt gttacgccat gtgccagtac tgatgtatgg cttggataat 15121 gaggatcacg tgtaattaag catgctttga taagctgtgc cattccataa aataaaagaa 15181 tcggtttgat ttctaaggga gaatatgcgg cttgtttata aaacgattcg gcatgcttta 15241 agaaataaat aaaccgttca ctgtttttaa aagagttttt tttcgcatcg ttaataccgt 15301 ttaagatata aaccttttct agaaatttct gggttgattc aacggagtaa aatagcgcta 15361 agtctttcca ctcatgatat gtcatgtata tttcttaatc ctttccgtta tctaaatatt 15421 tcaactcttt cccgcttcct tgacatgctc ttggctagtt gataatctac atataatatt 15481 ttgccgaaaa gagggggatt tactaatgtg ggaaagtaaa ttttcaaaag aaggcttaac 15541 gttcgacgat gtgctgcttg taccagcaaa gtctgaggta cttccgcgtg atgtggattt 15601 atctgtagaa cttacaaaaa cgttaaagct aaatattcct gtcatcagcg caggtatgga 15661 cactgtaaca gaatcagcaa tggcaattgc aatggcaaga cagggcggct tgggcatcat 15721 tcacaaaaat atgtccattg aacagcaggc tgaacaagtt gataaagtaa agcgttctga 15781 gcgcggcgtt atcacaaatc ccttcttttt aactcctgat caccaagtat ttgatgcgga 15841 gcatttgatg gggaaataca gaatttccgg tgttccgatt gtaaataacg aagaagacca 15901 gaagcttgtt ggaattatta caaaccgtga ccttcgtttt atttctgact actcaatgaa 15961 aatcagcgac gtcatgacga aagaagagct agttactgca tctgtaggaa ctactctgga 16021 tgaagctgaa aagattttgc agaaacataa aattgaaaag cttcctctcg tagatgacca 16081 gaataaatta aaaggtctta tcacaattaa agacattgaa aaagtcattg agttcccgaa 16141 ctcatctaaa gacattcacg gccgcctgat cgttggcgcg gcagttggtg taactggcga 16201 tacaatgact cgcgtcaaaa agcttgttga agccaatgtt gatgtgattg ttatcgatac 16261 agctcacgga cactctcaag gcgttttaaa cacagtcaca aaaatccgtg aaacgtatcc 16321 cgaattaaac attattgctg gaaacgtggc aacagctgaa gcgacaagag cgcttatcga 16381 agctggagca gacgttgtca aagttggaat agggcctggt tcaatttgta ctacacgtgt 16441 tgtagccggc gtgggtgttc cgcaaattac agcaatttat gattgtgcga ctgaagcaag 16501 aaaacacggc aaaacaatca tcgccgacgg tgggattaaa ttctctggcg atatcactaa 16561 agcattggca gccggcggac atgctgttat gctcggaagc ttgcttgcag gcacatcaga 16621 aagccctggt gaaactgaaa tctaccaagg cagaagattt aaggtatacc gcggcatggg 16681 atcagttgct gcaatggaaa aaggaagtaa agaccgttac ttccaagaag aaaacaaaaa 16741 atttgttcct gaaggaattg aaggacgcac accttacaaa gggccagttg aagaaaccgt 16801 ttatcagcta gtcggaggcc ttcgttctgg tatggggtat tgcgggtcca aagatctgcg 16861 tgcgctaaga gaagaagctc agttcattcg catgactggc gcaggacttc gcgaaagcca 16921 tccgcatgac gtacagatta caaaagaatc acctaactat acaatttcat aataaattgt 16981 tacaaattaa aaacatttga cagggtctct gactctgtct atttttttta tactgattat 17041 gataaaattt atactgttgt gcattgaaaa tgtccttaac ggcttaatta tagatgaaga 17101 aaatgaaata cggaggtcgt acgattgaac atcaagaaat gtaaacagct actgatgtca 17161 ttggttgtgt taactctagc tgtcacgtgt ctggctccaa tgtcaaaagc gaaagcagcc 17221 agcgatccaa ttgatatcaa tgcatctgct gctattatga tcgaagcttc ttcaggtaaa 17281 attctttaca gtaaaaatgc agataagaga ctgccaattg cgagtatgac aaaaatgatg 17341 acagagtatc tgttattgga agcaattgat caaggtaaag tgaaatggga ccaaacctat 17401 acgcctgatg actatgtgta tgaaatttcc caagataaca gcttatcaaa cgttcctctt 17461 cggaaagacg ggaaatacac agtaaaagaa ttatatcaag ctacagcaat ttattctgca 17521 aatgctgctg ctattgcgat tgcagaaatc gttgccggtt ctgaaactaa gtttgttgaa 17581 aaaatgaatg caaaagcaaa agaactaggc ttaacagatt acaaatttgt taacgcaaca 17641 ggtcttgaaa acaaagatct tcacgggcat cagcctgagg ggacaagcgt aaatgaagaa 17701 agtgaagttt ctgcaaagga tatggcggtt cttgcggatc acttgattac tgactaccct 17761 gagatactgg agacttccag tatcgccaaa acgaaattca gagaaggcac cgatgatgaa 17821 atggacatgc cgaactggaa ttttatgctg aaggggcttg tcagcgagta taaaaaagcg 17881 actgtagacg gactgaaaac aggttctact gactctgcgg gttcatgctt tacaggaaca 17941 gctgaacgca acggtatgcg tgtcatcact gttgttttaa acgcaaaggg caaccttcat 18001 acaggccgtt tcgatgaaac gaaaaaaatg tttgattatg ctttcgacaa tttctccatg 18061 aaagaaattt atgctgaagg cgatcaagta aaaggccata aaacaatttc agttgataag 18121 ggtaaagaga aagaagtagg cattgtgaca aacaaggcgt tctctcttcc tgtcaaaaat 18181 ggtgaagaaa agaattacaa agcgaaggtc acactgaata aagacaactt aactgctcct 18241 gtgaaaaaag gaaccaaggt tgggaagctg actgcggaat acacaggtga tgaaaaggat 18301 tacggattcc ttaacagcga tctggctggc gtagaccttg ttacaaaaga aaatgtagaa 18361 aaagcaaact ggtttgtttt gacaatgcgc agtatcggcg gattttttgc cggaatttgg 18421 ggaagcattg ttgatacggt aaccggctgg ttttaatcaa ttgaaagagc tctgatggat 18481 gttagggctc tttcgcgtaa tatactgaaa aaacccaatt tttaataaaa aatgattttc 18541 aaagcgctaa aaaccgaata aaatagtata tatgcatatg aattattgga tttctaggat 18601 acaataagga ttagaaatca tataactata ccttgattag ggggaccaag aaatggctca 18661 aacaggtact gaacgtgtaa aacgcggaat ggcagaaatg caaaaaggcg gcgtcatcat 18721 ggacgtcatc aatgcggaac aagcgaaaat cgctgaagaa gctggagctg tcgctgtaat 18781 ggcgctagaa cgtgtgccag cagatattcg cgcggctgga ggagttgccc gtatggctga 18841 ccctacaatc gtggaagaag taatgaatgc agtatctatc ccggtaatgg caaaagcgcg 18901 tatcggacat attgttgaag cgcgtgtgct tgaagctatg ggtgttgact atattgatga 18961 aagtgaagtt ctgacgccgg ctgacgaaga atttcattta aataaaaatg aatacacagt 19021 tccttttgtc tgtggctgcc gtgatcttgg tgaagcaaca cgccgtattg cggaaggtgc 19081 ttctatgctt cgcacaaaag gtgagcctgg aacaggtaat attgttgagg ctgttcgcca 19141 tatgcgtaaa gttaacgctc aagtgcgcaa agtagttgcg atgagtgagg atgagctaat 19201 gacagaagcg aaaaacctag gtgctcctta cgagcttctt cttcaaatta aaaaagacgg 19261 caagcttcct gtcgttaact ttgccgctgg cggcgtagca actccagctg atgctgctct 19321 catgatgcag cttggtgctg acggagtatt tgttggttct ggtattttta aatcagacaa 19381 ccctgctaaa tttgcgaaag caattgtgga agcaacaact cactttactg attacaaatt 19441 aatcgctgag ttgtcaaaag agcttggtac tgcaatgaaa gggattgaaa tctcaaactt 19501 acttccagaa cagcgtatgc aagaacgcgg ctggtaagaa cataggagcg ctgctgacat 19561 gttaacaata ggtgtactag gacttcaagg agcagttaga gagcacatcc atgcgattga 19621 agcatgcggc gcggctggtc ttgtcgtaaa acgtccggag cagctgaacg aagttgacgg 19681 gttgattttg ccgggcggtg agagcacgac gatgcgccgt ttgatcgata cgtatcaatt 19741 catggagccg cttcgtgaat tcgctgctca gggcaaaccg atgtttggaa catgtgccgg 19801 attaattata ttagcaaaag aaattgccgg ttcagataat cctcatttag gtcttctgaa 19861 tgtggttgta gaacgtaatt catttggccg gcaggttgac agctttgaag ctgatttaac 19921 aattaaaggc ttggacgagc cttttactgg ggtattcatc cgtgctccgc atattttaga 19981 agctggtgaa aatgttgaag ttctatcgga gcataatggt cgtattgtag ccgcgaaaca 20041 ggggcaattc cttggctgct cattccatcc ggagctgaca gaagatcacc gagtgacgca 20101 gctgtttgtt gaaatggttg aggaatataa gcaaaaggca cttgtataaa acagttgaaa 20161 gctgtggaaa cttatagtac attataagca caaataaaga tcgaaaagcg ttgataggaa 20221 ctagtaggga gcctctcttt ctaagagagc cgatggttgg tgcgaatcgg tgaaagatgc 20281 tgtctgaatc catccttgag cgaaatgctg aagcgagtag gcatttacgg gataaccgtt 20341 atgtttgaaa gtggaaaacg agtctttgat ttgttttcaa tcagggtggc aacgcgagag 20401 ctctcgtccc tttatgggga tgagggctct ttttattttc gataaatcaa taaaaaaagg 20461 agtgtttcgc atgcttgata cgaaaatgct gagagcaaat tttcaagaaa ttaaagcaaa 20521 gcttgtacac aaaggcgaag acttaactga ttttgataag tttgaggcgc tggatgatag 20581 acgaagagag cttatcggca aggttgaaga gttaaaagga aaacgaaatg aagtttctca 20641 gcaggttgct gtgctgaagc gtgagaaaaa agacgcggat cacattatta aagaaatgcg 20701 tgaagtcggc gaggaaatta aaaagctcga tgaagaatta cggacagtgg aagctgagct 20761 tgatacaatc ctgctctcaa tcccgaatat tccgcatgag tctgtacctg tcggtgaaac 20821 agaagacgac aacgtagaag tgcgtaaatg gggtgaaaag ccttcatttg cttatgagcc 20881 gaagccgcac tgggatattg cggatgagct gggtattctg gattttgaac gtgctgccaa 20941 agtaacagga agccgtttcg tgttctataa aggcttaggt gctcgtctgg agcgtgcgct 21001 ttataacttt atgcttgatc tgcatgtgga tgagtataac tacactgaag tgatcccgcc 21061 atatatggta aaccgcgcaa gcatgacggg aacggggcag cttcctaaat ttgaagagga 21121 tgcatttaaa atcagagaag aagattattt cttaattcca acggcggaag tgccgattac 21181 aaacatgcat cgcgatgaaa tcctttcagg tgacagcctg ccgatcaact atgcggcatt 21241 cagtgcttgc ttccgttctg aagctggttc agcaggacgt gacacacgcg gattaattcg 21301 tcagcaccaa tttaataaag ttgagcttgt aaagtttgtg aagcctgaag attcttatga 21361 agaattagag aaacttacaa accaagcaga acgggttctt cagctgcttg agcttccata 21421 ccgtgtcatg agcatgtgta cgggtgactt aggctttacg gctgcgaaaa aatacgatat 21481 cgaagtttgg attccaagcc aagacacata tcgagaaatc tcttcttgca gcaacttcga 21541 agcgttccag gcgagacgtg cgaatattcg tttcagacgt gaagcgaaag gcaagcctga 21601 gcatgtacac acactgaacg gctcaggact ggcggttgga agaacagttg ctgctatctt 21661 agaaaattat cagcaggaag acggaagcgt tgtgattccg aaagtgcttc gtccttatat 21721 ggggaataga gaagtaatga aaccgtaaat tatggaaagg cgtgcctgac aaggtgcgcc 21781 tttttgctta tgtaaacacg gcattttcat aaaaacaaaa aaagttttta aaaatgcttg 21841 accacacgag aacatacgtg atatagttag tcttgtcgat acggaggaat acccaagtcc 21901 ggctgaaggg atcggtcttg aaaaccgaca ggggtgtcaa agcccgcggg ggttcgaatc 21961 cctcttcctc cgccatattg attttaattc taatgaaaca caagcatata ttggagattg 22021 ttttgtccgt tgcattcggt gcggcggatt ttttatttta aagaaaaagt gaatctcgac 22081 tgagattcac tttttttgat tatcatgaat aactgaagca atttgatcta caatattttc 22141 aatcgagttt tcgtcgttca gaagatcata atcttcaatg cgaagtttta aaacagggca 22201 ggcattaaaa ccgcttatcc agttctcgta gcgtgtatgc atttcttccc aataagaccg 22261 gcttgtctga agctccatct cacggccgcg ttgttcaatc cggtttaaaa tgttctccag 22321 atctccttct aaatagatca acacatctgg atgtgggaaa tacggtgtca ttaccattgc 22381 ttcgaaaagg cttgtgtaag tcttataatc aacctttgac attgtccctt tatcagcatg 22441 catttttgcg aaaattcctg tatcttcata aatcgaacga tcctgtacaa aacctccgcc 22501 ggcttcaaaa attgttttct gttctttgaa gcgttcagct aagaagtaaa tttgaaggtg 22561 aaagctccaa cgttcaaaat catgatagaa cttttccaaa tatggattat gatcgacttc 22621 ctccaacgat gttttaaatc caagccgttt agctaaagtt tttgttaaag tcgattttcc 22681 gacacctact gttcctgcta ctgtaataat tgaattctta gggatatgat gttccttcat 22741 acgataagct cctttacatg ggcggcaatg cgttcaaagt cgctcttatt caaaacgaaa 22801 tcctttgaat caccatctac ggttaacact gtaagttcag ggtctgcttc ctgcagctgc 22861 ttgatggcga cttcataatc tgaaatcagc tgctccaaat agctagtttc aatttttttc 22921 tcaaaggggc gcccgcgttt ttcaatgcgg tgtagcaatg taggcagact ggcctttatg 22981 taaatgatga aattcggctt tggcagatca tccgttagca ggtgatatat ctttttgtat 23041 ttttccagct gatgtggaga caaggttcgt tccgcaaaaa tcacattttt ataaatatga 23101 taatcagcta ttacaggctg tccctttttt aaaaagtgat cactggtgtc ttcaagctgt 23161 ttgtatctgt gacaaagaaa aaacatctcg agctggaagc tccattcctt tatattgtca 23221 taaaacttat caaggtacgg gttatcctct acaatctcat tgatcatagg gaatccgaat 23281 ttttgtgaga gcatcgttgc gagagttgtt tttcctgccc cgataggacc ttctattgca 23341 ataaaagggg ctgtattcat cggaatcctc cttatatctg aaaaacgtgc gtcagttacc 23401 gaccttcata ttgtatcaca acccttgggt gcccccatga aaaaaagacg tttccaaatt 23461 atcgaaacgt ctttttgaca acattaaatt gatcagacag cagcagccag ttttgtggaa 23521 aggaaagacc cagcttccaa tagctgatgc ctcttaaatt cagctcttta atcagattga 23581 attttgcttg aatcgagcgg gcatcctcga accatacctc gtgccttctg ttttctgcat 23641 cagtatagcg gaagaaagga gcttgagcgg tttggtcata ctgaatggaa gcattgttct 23701 gatcagctat gacaatggct tgctgagggc ttactgctct tgctggagtt ccccctgctg 23761 tatatggcag cgtccagtca tatccatata aattctggcc catgacaatt ttgttcgcag 23821 gcatttcagt caaagcatat tctatgacat cacggacagg tccaattgga gaaaccgctt 23881 gaggcggtcc gccgctatag ccccattcat atgtcatgag aacaacaaag tcgacaattt 23941 cgccatgtgc cctgtaatca tgagcttcat accacctgcc ctgctgtgtt gcacttgttt 24001 taggagcaag agccgtagaa atttctaagc cctctcgatg gaaaagatcc cttgcttcgc 24061 ggaggaattg attataggcc tctctatcct ggggccgcaa atattcaaag tcgaaatgaa 24121 tgtcacggaa gccatatctt ctggcattct cgactatttc atttagaagc cgtcttttta 24181 cagtttcgtc gttcaaaagg atccggccaa gttcatcgct gaatgcctgg ttttctaggt 24241 tcgttataat catcatcaat gttgtatttt gactttctgt aatgctcctt aaattcgtta 24301 aaggcggtgc gactaaggtt ccgttccgct gtgcctggaa gctgaatgcg ccaaggtaag 24361 ttaagtaggg cgacgcttct ctggccgcct gctggagatt ttcgctgact tgatttcctc 24421 ggggctccaa ataagcattt gattcgatgt ctcgtttagg agctggaggg atgtataaac 24481 ggaaaccaat ctgaagcacg gtatttaact ggatgcggtt aacccttgcg agctcggctg 24541 ctgttgtatt gaactgccgg gcgatggatg tcagggtatc acctcgcttc acatcataga 24601 actggccagc tattggaatg acaatggttt gtccgacaac aaggctgtcg ggattcggta 24661 tttcattcgt ttcagtgatg tcatttgtgg ttgttctgta ttgtgaagcg atagcagaaa 24721 gagtgtcgcc ttgttttacc acataaattt gaatgaaaaa cgcctccttt catatcgcta 24781 tcaatgtatg aaagaaaagc gctgatcatg tttatttttc tataatttgt tcttccgtcg 24841 taatttctgc gaaaagaaca ttctccatca tggttaaggc gaattcgtta tcttcgtcac 24901 tgtttgacgc gatacagtcc ttaggaatcg tgatgctgta ttccctcata taagcgtcat 24961 tagcggtaaa cagcacgcat atattgccgg ctatacctgt tatgataata tgtctcacct 25021 gcaactcagt aagaagggtg tgaagtgctg tttcgtagaa agcggaatgt ttcggtttga 25081 ttaaaaaata atcagcatct accggagcta tctttgtgat gatatccttg cttctttcat 25141 ttgtgcattc ttgctgtatg tttttaatgt cagcttgcca aagtccataa tgatcattga 25201 tgtaaataat cggccattca ttttgtctcg cgtgctcctt taatgataaa atatgaggaa 25261 cgattttttc tgttttttta gcgagggttt cccccatatc gaattcaaaa ttattgatca 25321 tgtctacaat gagaagggct ttatctgctt tggacaatcg acagtctcct ttccgtttca 25381 gttatagtta atatgtagcc tttttaggca atgaaaaaac tttgaaaaga gagcttatcc 25441 ttatgacaca agatgaactt tatatgaaag aagcaattaa agaagcgaaa aaggctgaag 25501 agaaaggtga agtgccaata ggtgcggtgc ttgtcattaa tggtgaaatt atagcgcgtg 25561 cgcataattt aagagagact gaacagcgat ctattgccca tgcagaaatg cttgtaattg 25621 atgaagcgtg taaggcactc ggaacatggc ggctggaagg tgcgactctt tatgtgacgc 25681 ttgagccttg tccaatgtgt gctggtgcag tcgtactttc tcgagtggaa aaagtggttt 25741 ttggcgcatt tgatccgaaa ggcggctgtt caggcacgct aatgaacctt cttcaggagg 25801 aacgctttaa tcatcaggct gaagtggtga gcggtgtgct tgaggaagaa tgcggcggaa 25861 tgctcagtgc gtttttcaga gaactaagaa aaaagaagaa agccgccagg aaaaacttgt 25921 ctgaatagta cggttgcaat ttttagggga aacagatata cttaagtgtg catcgtaata 25981 gatgcaacat aaaatttgat atttattttg ccgtgctaag cggggaggta gcggtgccct 26041 gtacctgcaa tccgctctag cagggccgaa tcccttctcg aggttcgttt actttaaggc 26101 ctgccttaag taagtggtgt tgacgtttgg gtcctgcgca atgggaattc atgaaccatg 26161 tcaggtccgg aaggaagcag cattaagtga aacctctcat gtgccgcagg gttgcctggg 26221 ccgagctaac tgcttaagta acgcttaggg tagcgaatcg acagaaggtg cacggtaaat 26281 caatcatcaa attttcagac tcacctaata ttaggtgagt tttttgttat gtaaaaagag 26341 cttttggaat cgaaacaagg ttcatgtata atgggaatga tgaataacgg aggagggcaa 26401 acccgtgagt taccaagctt tatatcgagt attcaggcct cagcgctttg aagatgtggt 26461 cggacaagaa cacattacaa aaacgctgca aaatgccctt ttgcaaaaaa agttttctca 26521 cgcctatctg ttttccgggc ctagaggaac cggaaaaacc agtgcagcca aaatatttgc 26581 taaggctgtc aactgtgaac atgctcctgt tgatgagcca tgcaacgaat gtgcggcctg 26641 taaagggata acaaacgggt caatatccga tgtcatagaa attgacgccg cttctaataa 26701 cggtgttgat gagattcgtg acattcgcga taaagtgaag tttgccccat cggccgtcac 26761 atataaggta tatatcatag atgaggtgca tatgctttct atcggcgctt ttaatgcatt 26821 actaaaaaca ttagaagagc cgcctgagca ttgtattttc atattagcaa caactgaacc 26881 gcacaaaatt cctttaacca ttatctctag atgtcagcgt tttgacttta aacgaattac 26941 ctcccaagcg attgtaggcc gcatgaataa aattgttgat gctgaacagc tgcaagtgga 27001 ggaaggatcg ctggaaatca tcgcgagtgc tgcagacgga gggatgaggg atgccctgag 27061 ccttcttgat caggccatat cattcagcgg cgatatcctg aaagtcgaag atgcgctttt 27121 aattacgggt gctgtttctc aattatatat cgggaagctt gcaaaatccc tgcatgataa 27181 aaacgtttct gacgcactgg aaacattaaa tgaattgctt cagcaaggaa aagatccagc 27241 taagctgata gaagatatga ttttctattt cagggacatg ctgctgtaca aaacagcccc 27301 tggcttagag ggagtgcttg agaaagtaaa agtcgatgaa acgttccggg aactaagtga 27361 acaaattccg gctcaggccc tatatgaaat gattgatatt ctgaacaaga gccatcagga 27421 aatgaaatgg acaaatcatc cgcgtatctt tttcgaagtg gccgttgtga agatttgcca 27481 aacctcacat caatctgctg ctgatctccc ggaagtggat atgctgatga aaaaaatcca 27541 gcagctcgaa caggaagtag agcggctcaa aacaacgggc ataaaagcag ctgcggaaag 27601 cccgaaaaaa gaagcgccgc gtgtgccaaa gggcgggaaa tccaattaca aagcgccagt 27661 aggcagaatt catgagattt tgaaggaagc cacaagaccg gatcttgatc tgctcagaaa 27721 cagttggggc aagcttcttg ctcatctcaa acagcaaaac aaagtatcac atgccgcttt 27781 gctgaatgac agtgaacctg tggctgccgg atcggcggca tttgttctga aattcaaata 27841 tgaaattcat tgtaaaatgg tcgctgagga taacaacgga gtccggacta atcttgagca 27901 gattttagaa tcgatgctcg gaaaaagaat ggatttgatt ggcgttccag aagcacaatg 27961 gggtaaaata agagaagaat ttttagaaga tcatcagcag gaaaatgaag gatcaaatga 28021 accggctgaa gaagacccgc ttattgccga agcgaaaaag cttgttggag cggatttaat 28081 tgaaataaaa gactaacaaa atgaaagaga gtgaatgcta tgcgtggcgg aatgggtaat 28141 atgcaaaaaa tgatgaaaca aatgcaaaaa atgcaaaagg acatggcgaa ggctcaagaa 28201 gagcttgcag aaaaggttgt tgaaggaact gcaggcggcg gtatggtaac agtaaaagca 28261 aacggccaaa aagaaatcct ggatgttatc atcaaagaag aagtcgttga tcctgaagat 28321 attgatatgc ttcaagattt agtgcttgct gcaacgaatg aagctttgaa aaaagttgac 28381 gaaatcacaa acgaaacaat gggtcaattt acaaagggaa tgaacatgcc aggtttattc 28441 tagggggata aaagaacatg caatatcctg aaccaatatc aaagctgatt gacagcttta 28501 tgaaattgcc agggatcgga ccgaaaacag cggttcgtct ggcttttttt gttctaggta 28561 tgaaagaaga tgtagtatta gattttgcga aagcattagt aaatgcgaaa cgcaacctga 28621 catattgttc agtttgcggg catattacag atcaggaccc ttgctatata tgtgaagata 28681 cgcgcaggga taagtctgtt atctgtgttg tgcaagaccc taaagacgtt atcgctatgg 28741 agaaaatgaa ggaatacaac ggacagtatc acgttcttca cggcgctatt tctccaatgg 28801 acggcatcgg accggaggat attaaaatac cagaattgtt aaaacgatta caggatgatc 28861 aagtgacaga agtgatcctc gcgacaaacc ctaatataga aggggaagca acagcgatgt 28921 atatatcaag gctcctcaag ccgtctggta ttaagctctc ccgtattgcc cacggactgc 28981 ccgtcggcgg tgatttggaa tatgctgatg aggtcactct ttctaaagca cttgaaggaa 29041 gacgtgaatt gtaaggagga aaaagcgatc catgggtttt cttcgcaaga aaacattaag 29101 aagagagttt gatgaaaaac taaccgagca gctttttaag caaaaggaag agtggaacag 29161 gcaaaaaaag ctggttgaaa aaagcttaga accgtctgct gaagtgttat acgaactgaa 29221 agtagctgaa gcgaagtatt ttttttactt aagggaagcg aagcagcgaa atttaaaaat 29281 cagccggtgg aagtaagtgg tctaaactcc tggatcttct cataagcttg tactagaaca 29341 agcgaaggag atgagaagat tcatggagcc tatttttatt attgggatta ttttaggact 29401 ggttattctt ctttttttat caggttcagc agcgaagcct ttaaagtgga ttggcatcac 29461 agctgttaaa tttgtggcag gtgctttgct gctggtttgt gtaaatatgt ttggcggcag 29521 tcttggcatt catgtgccga ttaatctggt tacaacagct atcagcggaa ttttaggaat 29581 acccggaata gctgcgttag tcgtcattaa gcaatttatc atttaattga tattatgtat 29641 tgacttagac aactgaaggt gttattctaa tatacgtcgc tgatgacgaa cagctttttt 29701 gaaaagaaaa tgctaaaaag ttgttgacag tagcggcggt aaatgttatg ataataaagt 29761 cgcttaaacg agcggtaaac aaagttcttt gaaaactaaa caagacaaaa cgtacctgtt 29821 aattcatttt tataaatcgc acagcaatgt gcgtagtcag tcaaactact ttatcggaga 29881 gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa gtcgagcgga 29941 cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg tgggtaacct 30001 gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt tgtttgaacc 30061 gcatggttca aacataaaag gtggcttcgg ctaccactta cagatggacc cgcggcgcat 30121 tagctagttg gtgaggtaac ggctcaccaa ggcgacgatg cgtagccgac ctgagagggt 30181 gatcggccac actgggactg agacacggcc cagactccta cgggaggcag cagtagggaa 30241 tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga aggttttcgg 30301 atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg gtaccttgac 30361 ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 30421 gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct taagtctgat 30481 gtgaaagccc ccggctcaac cggggagggt cattggaaac tggggaactt gagtgcagaa 30541 gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag gaacaccagt 30601 ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg gggagcgaac 30661 aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt tagggggttt 30721 ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta cggtcgcaag 30781 actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt ggtttaattc 30841 gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta gagataggac 30901 gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg tgtcgtgaga 30961 tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc attcagttgg 31021 gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg tcaaatcatc 31081 atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag ggcagcgaaa 31141 ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt ctgcaactcg 31201 actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg aatacgttcc 31261 cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga agtcggtgag 31321 gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga agtcgtaaca 31381 aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat tttacggaat 31441 ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt gaaggaactt 31501 tgttccttga ataagttaag atgggcctgt agctcagctg gttagagcgc acgcctgata 31561 agcgtgaggt cggtggttcg agtccactca ggcccaccat cttatataac ggggccttag 31621 ctcagctggg agagcgcctg ctttgcacgc aggaggtcag cggttcgatc ccgctaggct 31681 ccaccaacgt gttctttgaa aactagataa cagtagacat cacattcaat tagtaacaca 31741 agatatcaca tagtgattct ttttaacggt taagttagaa agggcgcacg gtggatgcct 31801 tggcactagg agccgatgaa ggacgggacg aacaccgata tgcttcgggg agctgtaagc 31861 aagctttgat ccggagattt ccgaatgggg aaacccacca ctcgtaatgg agtggtatcc 31921 atatctgaat tcataggata tgagaaggca gacccgggga actgaaacat ctaagtaccc 31981 ggaggaagag aaagcaaatg cgattccctg agtagcggcg agcgaaacgg gattagccca 32041 aaccaagagg cttgcctctt ggggttgtag gacactctgt acggagttac aaaggaacga 32101 ggtagatgaa gaggtctgga aaggcccgcc ataggaggta acagccctgt agtcaaaact 32161 tcgttctctc ctgagtggat cctgagtacg gcggaacacg tgaaattccg tcggaatccg 32221 ggaggaccat ctcccaaggc taaatactcc ctagtgaccg atagtgaacc agtaccgtga 32281 gggaaaggtg aaaagcaccc cggaagggga gtgaaagaga tcctgaaacc gtgtgcctac 32341 aagtagtcag agcccgttaa cgggtgatgg cgtgcctttt gtagaatgaa ccggcgagtt 32401 acgatcccgt gcaaggttaa gcagaagatg cggagccgca gcgaaagcga gtctgaatag 32461 ggcgcatgag tacgtggtcg tagacccgaa accaggtgat ctacccatgt ccagggtgaa 32521 gttcaggtaa cactgaatgg aggcccgaac ccacgcacgt tgaaaagtgc ggggatgagg 32581 tgtgggtagg ggtgaaatgc caatcgaacc tggagatagc tggttctctc cgaaatagct 32641 ttagggctag cctcaaggta agagtcttgg aggtagagca ctgattggac taggggcccc 32701 taccgggtta ccgaattcag tcaaactccg aatgccaatg acttatcctt gggagtcaga 32761 ctgcgagtga taagatccgt agtcgaaagg gaaacagccc agaccgccag ctaaggtccc 32821 aaagtatacg ttaagtggaa aaggatgtgg agttgcttag acaaccagga tgttggctta 32881 gaagcagcca ccatttaaag agtgcgtaat agctcactgg tcgagtgact ctgcgccgaa 32941 aatgtaccgg ggctaaacgt atcaccgaag ctgcggactg ttcttcgaac agtggtagga 33001 gagcgttcta agggctgtga agccagaccg gaaggactgg tggagcgctt agaagtgaga 33061 atgccggtat gagtagcgaa agaggggtga gaatcccctc caccgaatgc ctaaggtttc 33121 ctgaggaagg ctcgtccgct cagggttagt cgggacctaa gccgaggccg aaaggcgtag 33181 gcgatggaca acaggttgat attcctgtac cacctcctca ccatttgagc aatgggggga 33241 cgcaggagga tagggtaagc gcggtattgg atatccgcgt ccaagcagtt aggctgggaa 33301 ataggcaaat ccgtttccca taaggctgag ctgtgatggc gagcgaaata tagtagcgaa 33361 gttcctgatt ccacactgcc aagaaaagcc tctagcgagg tgagaggtgc ccgtaccgca 33421 aaccgacaca ggtaggcgag gagagaatcc taaggtgatc gagagaactc tcgttaagga 33481 actcggcaaa atgaccccgt aacttcggga gaaggggtgc tctgttaggg tgcaagcccg 33541 agagagccgc agtgaatagg cccaggcgac tgtttagcaa aaacacaggt ctctgcgaag 33601 ccgtaaggcg aagtataggg gctgacgcct gcccggtgct ggaaggttaa gaggagcgct 33661 tagcgtaagc gaaggtgcga attgaagccc cagtaaacgg cggccgtaac tataacggtc 33721 ctaaggtagc gaaattcctt gtcgggtaag ttccgacccg cacgaaaggc gcaacgatct 33781 gggcactgtc tcaacgagag actcggtgaa attatagtac ctgtgaagat gcaggttacc 33841 cgcgacagga cggaaagacc ccgtggagct ttactgcagc ctgatattga atgttggtac 33901 agcttgtaca ggataggtag gagccttgga aaccggagcg ccagcttcgg tggaggcatc 33961 ggtgggatac taccctggct gtattgacct tctaacccgc cgcccttatc gggcggggag 34021 acagtgtcag gtgggcagtt tgactggggc ggtcgcctcc taaaaggtaa cggaggcgcc 34081 caaaggttcc ctcagaatgg ttggaaatca ttcgcagagt gtaaaggcac aagggagctt 34141 gactgcgaga cctacaagtc gagcagggac gaaagtcggg cttagtgatc cggtggttcc 34201 gcatggaagg gccatcgctc aacggataaa agctaccccg gggataacag gcttatctcc 34261 cccaagagtc cacatcgacg gggaggtttg gcacctcgat gtcggctcat cgcatcctgg 34321 ggctgtagtc agtcccaagg gttgggctgt tcgcccatta aagcggtacg cgagctgggt 34381 tcagaacgtc gtgagacagt tcggtcccta tccgtcgcgg gcgcaggaaa tttgagagga 34441 gctgtcctta gtacgagagg accgggatgg acgcaccgct ggtgtaccag ttgttctgcc 34501 aagggcatcg ctgggtagct atgtgcggac gggataagtg ctgaaagcat ctaagcatga 34561 agcccccctc aagatgagat ttcccattcc gcaaggaagt aagatccctg aaagatgatc 34621 aggttgatag gtctgaggtg gaagtgtggc gacacatgga gctgacagat actaatcgat 34681 cgaggactta accacatttt gaatgatgtc acacctgtta tctagttttg agagaacacc 34741 tctctaaagg cggaaggtaa ggaaactccg ctaagggctc tcacatcctg tgagaaacgc 34801 ccagtacctt catcctgaag gcatttgttt ggtggcgata gcgaagaggt cacacccgtt 34861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 34921 gtgagagtag gacgccgcca agcaagctta aacccagctt aatgagctgg gttttttgtt 34981 tactcaagat cgagaaaatc aaacaaatac aaacaccgag ggcttatata gcccatatac 35041 tgatttaaag tttcaaaaag gtctaaatag tgtatacaat atccgtttta aggggaggct 35101 aactgtacgg aggtggagaa gatggacgaa acagttaaac ttaatcatac atgtgtgatt 35161 tgtgatcaag agaagaatag aggcattcat ctttatacga aattcatatg cttagattgt 35221 gagagaaaag taatttctac atcaacttct gatcctgact atgcgtttta cgtaaaaaaa 35281 ctaaagagca ttcatacacc gccattatat tcatagacct gaaaaggtct ttttttgtac 35341 tcttaataat aaaaagaaga tgaaacttgt ttaaggattg aacgtagtag ataataatat 35401 taaaactgag tatagacaca ggagtcgatt atctcatgca gagatttttt cactttttgg 35461 tgtggagttt aactagcagt gcgacttttg ttttcattgg aatattgagc ttttttggtt 35521 taaaccagtc gattttttta tctattgttt atgggcttgc ttctggagca gccgtatata 35581 tagctggcat ctggaatgca agacggttat ttcttaaaaa gcatgaattg acaggaagag 35641 agtatgctta cattaagaaa aacttagagg aagcaaggca gaaaatggtc cgtcttagga 35701 aagccttgtt tcaggctaaa agcattcaaa tgtttaagca aaatgcagaa atgctaagga 35761 ttgtgagaag gatttatctc ctcaccaaaa aagagccaaa gcggttttat caggcagaac 35821 gattttttta tcaaactctc gattcggttg ttgaattgac agagaagtat gcttttctat 35881 catctcaccc aaaaaaaagc aaagaactgt cgatgtcgtt aagtgagaca cgcatcactc 35941 ttactgaatt gaccaagcgt ttagaggaag atttaactca agcaatgggt gatgaaattg 36001 acgagttgca gtttgaatta gacgcagcaa aacattcatt aaagaaataa gggaagaggg 36061 taagagcgat gaaccgagac caaagcgacc ttcatataga tgaattattg gcagatcctt 36121 ttggtggtaa catagagata ccaggttcgg aggctgtaaa agcagagaaa gagcaagtac 36181 ggcttgttga tgttcttcct gaggaaaaca aggaaaaagc aattcagctt gctggacaga 36241 ttgatcataa aaatatgcaa agcattgtct tatacggttc acaagctcaa tctaaactgc 36301 tgaacttttc tcatgatatg attaatcatg ttcaaaagaa ggatgtcggg gagattggcg 36361 aaatacttgg agagctgatg aaaaagctgg agcaagtaaa tcctgatgat ctccaatcta 36421 agaaaaaggg ttttttggca cgcatgtttg gaagagtatc aagttctctt caagaggtgc 36481 tgtctaaata ccaaaagacc agtgtgcaga tagacagaat cagcttgaag ctggagcact 36541 ctaaaaatgc tttaatcagt gacaacaagc tgttagagca gttatatgaa aaaaataaag 36601 aatatttcgc agcgctgaat gtttatattg ctgcaggaga actgaagctg gaggaattaa 36661 aaacaaaaac gattcctgaa ctgaagcaac aggctgaatc gagtgatcat aaccaaatgg 36721 ccgttcaaga ggtgaatgat ttaattcaat ttgctgaccg gttagataaa agggtgcatg 36781 atttgctgct gagcaggcaa attacaatcc aaagtgcacc gcaaatcagg ctgattcaaa 36841 atacaaacca agcgttagct gaaaagattc agtcatccat tgtgacagcg attccgttat 36901 ggaaaaatca agttgccatt gcactgacgc ttttaaggca gcgcaatgca gtggatgcac 36961 agcagaaagt atctgataca accaatgagc ttttgctgaa aaatgcggag cttttaaaaa 37021 ccaatacaat tgaaactgca cgggcaaatg aaagaggcct tgttgatata gataccttga 37081 agaaggtgca ggaaagctta ataagcacgc ttgaagaaac actgactata caagaagaag 37141 gacgaatcaa acgccgtcag gcagaagaag agctcatgat gatggaaggc gacctgaagc 37201 aaaagctgat tacaataaag gaaagatgat taccagtaag tctggcttta agttctgtca 37261 gaggcacgat ataataaggt gtaagaagac acattcaaag gattgttttc atgaacacac 37321 ctttatataa agcattaatt caacatgcga gaagaaattc tcattcattt catgttccgg 37381 gacatcacaa tggagatgtc ttttttgatg acgctaagtc aatattcgat ccgcttctca 37441 ccattgatgt aactgaactg gcaggactgg atgatctcca tcatccttct ggggtgatta 37501 aggaagctca ggagcttgcc agtcaattat atggatcggc ggaaagtttt tttctggtaa 37561 atggtacgac tgtcggaaac ttagcgatga ttttatctgt ttgtgaacct ggtgatacaa 37621 ttctggttca aagaaactgt cataaatctg tatttcatgc tgttgatttg tccggtgctg 37681 agccggttta tcttgcacct gacgttgatt cagcgatgca tgtgcctacg catgttccgc 37741 ttggaacaat taaagaggcc ctggaagcat atccagatgc gaaaggcttg gtactgacca 37801 atccgacata ttacggacat agtgctgatt tgactgagat cattactgaa gcccatcatt 37861 acgggattcc tgttttggtc gatgaagcgc atggcgcaca ttttatttta ggtgagcctt 37921 ttccggtctc agctttaaaa atgggggcag atattgttgt tcagtcggcc cacaaaacgt 37981 tgccagccat gacgatgggt tcttatttgc atctcaacag cagctgcagg attaacaggg 38041 atcgggtggc agagtattta aaccgattac aaagcagcag cccgtcttat ccgattatgg 38101 cttcgttaga tattgcccgc gcttatgtac agcatattat agaagaacaa aagctttctg 38161 acattctgca gcggatagaa acacttaaac aaacgtttga ttcacttaca aatgcagaag 38221 ctgttaaccc tgctaatcca ctgatcatca cggatccgct aaagctcaca attcgttcaa 38281 aacgcgggca ttctggctat acgctgcaaa gcattttaga gcgtgccaac atattcactg 38341 agcttgctga tgaaaatcaa gttctgctcg ttctcccatt gggaggaaaa cggagaataa 38401 acgctgaaat cattagaagc atcgatgaag agattgagaa aacgcctccg gatcagacgt 38461 ttgtttctgc agaatggggt gtgcagcctg ttactgtctt gccttatcca aaaaaggtct 38521 tacattcgtt taagaaagaa tatgtgagct ttgaggaagc agctggccgg cttaatgcag 38581 aagatatcat cccttatcct ccgggtatcc cgatgattat ggcgggagaa agaataacaa 38641 aagaaagtgt gcaaaagctc agccgcttga tcagcatgaa aacgcatgtt caagggaata 38701 tgaaaatcaa agagaaacaa ctacttgttt atatagaaga ggagaaatca tgagcggttt 38761 atttattaca ttcgaaggtc ctgaaggtgc agggaaaacg actgttctgc aggagatcaa 38821 aaacatactg acagcagaag gccttcaggt tatggcaact cgagagccag gcggaataga 38881 tattgcagaa caaattagag aggttattct gaatgagaac aatatattaa tggacccaaa 38941 aacagaagct ctcttatatg cggctgcaag acgccagcat ttagttgaaa aagtaaaacc 39001 tgctttagaa caggggttta tcgttctttg cgacagattc atagacagtt ctcttgcgta 39061 tcaaggatat gcaagagggc ttggaattga tgaggttctg tccattaatg aatttgccat 39121 tggagatatg atgccccatg taacggttta tttttcaatt gatccggaag aaggactgaa 39181 gcgtatttac gcaaacggct cacgggagaa aaacaggctc gatttagaaa aactggactt 39241 tcatacaaaa gtacaagaag gttatcaaga gctgatgaag cgatttccgg aaagatttca 39301 ttcagttgat gccgggcaat ccaaagacct cgtcgttcag gatgttctaa aggtgatcga 39361 tgaagcgttg aaaaaaattc aattgtgacc tgtttcccaa tagttgatat aataatgtaa 39421 acgagatcac gttgtttcca atctaaagga ggccttcaca gatgaaattg atagtggcag 39481 ttgtacaaga tcaggacagc aacagacttt tgaaaacctt aacggatcac aacttcagag 39541 tcacaaagct tgcaacgaca ggaggatttc ttaaatcagg caatacaacg tttatgatcg 39601 gtgtcgagga tatacgcgtc aataaagcgt tgagtctcat taaagaaaac gggcagaaac 39661 gtgatcagat gattgcccct gtatctccaa tgggtggaaa tgctgattcc tatgtccctt 39721 atccagtcga agttgaagtt ggcggagcga cagtatttgt ccttccagtc gatgaatttc 39781 atcaatttta aggatctgaa actgtgaaaa ttaataaaga tatacgtaca tttatagata 39841 ataagcagat tccctctgtg aaaacatctg agatcacagc atcgtttaaa acatcaatgg 39901 aaaaccaaag cagcaaaatg aagcttgatc agcttaccag gctgttatct gatatagaag 39961 catttggaaa aaggctaacg aaatctcgga attttaaaga cttagcgaga tttaaaggac 40021 ttgtgaaacg ttttgtcaaa gaagctgtgg acagcggtct ttcacatgaa acatcgaaaa 40081 gctttgacct ttacgggaac agcagaacgc tgggacttgt gaaagaaata gatgacaaat 40141 tgatacagct tacggaagag atgatggatc aggaaaaacc ggcaattgat ttgctggagc 40201 gtattggcga aataaaaggt ttattaatta acctttacac atagagagtg atacaatggc 40261 aatatcctgg aaggaaatga acgagcttca gcccagagtg atgaagcttt tatataatag 40321 tattgagaag gacagactat cacacgctta tttgtttgag gggaaaaaag gaacaggcaa 40381 gcttgatgcc gcgctgcttc ttgcaaaaag cttcttttgt ctggagggtg gcgcggagcc 40441 ttgtgagagc tgccgaaact gtaaacggat agagtcaggg aaccatcctg atctccatct 40501 tgttcagcct gatggcttat caatcaaaaa ggcgcaaatt caagcgctcc aagaagagtt 40561 ttctaagaca ggacttgaat cgcataaaaa gctgtatatt atttcgcacg cagatcaaat 40621 gacagcaaat gcggcgaaca gcctgctgaa atttttagaa gaaccgaaca aagacacaat 40681 ggccgtcctc atcactgagc agccccaaag gttattggat accatcattt caagatgcca 40741 aacccttcct tttcagcctt tgcagccgaa agcaattgaa gacagactga tcgaacagga 40801 cgtctcgcct catatggcaa ggcttctggc caacatgact aataatgtag cagaagcagt 40861 cgaattaagt cgaaatgatg agtttgcaga gtctagagcg aaagtgataa aattgtatga 40921 agtcctacac cagcggaaag gacatgcttt tttctttatt caagatcaat ggatgccctt 40981 tttcaaagaa aaaacccatc aagaaatggg tcttgatatg ctcttattga tatatcgtga 41041 tgtgttgtcc atccaaatag gaaatgaaga taaattgatt tatcaagact tattccaatc 41101 aataaaacag catgcgctac aatcaacaca acaaagcgtt acgaatcaga tacttgctgt 41161 tttagaagca aagaaacggc ttcattccaa tgtgaatgta caaggattaa tggagcactt 41221 ggtgttaatg ttgcaggagg gataagcttg tacaatgtaa ttggtgtccg ctttaagaaa 41281 gcgggtaaaa tatattattt tgatccgaat ggatttcata tagaacatga cagctgcgta 41341 attgtagaaa ctgtcagagg cgttgagtac ggccaggtcg taattgcaaa taaacaggtg 41401 gatgagcatg atgtggtgct tccccttcga aaagtgatac gtgtggcaga cgatcgcgat 41461 cttctcattg tagaagaaaa taaacaggaa gcactatcag catttgatat ctgccaaaag 41521 aaagtgattg agcatggctt ggatatgaag ctggtcgatg ttgaattcac gtttgatcgc 41581 aataaagtca ttttttactt cactgctgac ggccgagtcg actttagaga gcttgtaaag 41641 gatttggctt ctatctttaa gacaagaatt gagctgcgcc aaatcggagt gagggatgag 41701 gcaaaaatgc tcggaggaat cggtccttgc ggaagaatgc tttgctgttc aacgtttctt 41761 ggagattttg aacccgtttc cattaaaatg gccaaggatc agaacttgtc tttaaatcct 41821 acgaagattt cgggtctttg cggacgattg atgtgctgtc taaaatatga gaacgatgag 41881 tatgagacgg caaaagaaca gcttccggat ataggagaaa tgattacgac agcaaacggt 41941 cccgcgaagg tcgtcggact aaatattctg gaacgggtgc ttcaggtgga actgataaac 42001 cgtgaaaaag tgatagaata tacttgggaa gagctcttgg aagagggcgt cgtatccgca 42061 caaaccacag attaacgagg tgtggaacct tggataaaaa agagttattt gatacagtca 42121 ttaacttaga agaacaaatt ggctcactgt accggcagct gggggatttg aagcagcata 42181 tcggtgagat gattgaggaa aatcatcatt tacagcttga aaacaagcat ttgcgcaaac 42241 ggctggacga tacgacgcag cagattgaaa agttcaaagc tgataaaaaa gaatcaaaaa 42301 cacagaagac agagcaaact gatatagggg aaggatatga taatctggca cgtctgtatc 42361 aagaaggatt tcatatctgc aatgtccact atggaagtgt tcgaaaagag gattgtcttt 42421 tctgtctgtc attcttaaat aaaaaatagg gaaaaggctt ccgcataaga cgggagcctt 42481 tttcaaaggt actgaaagga taagaagatg gtttcattac atgatgatga aagattagat 42541 tatttgctgg cagaggacat gaaaatcata caaagcccaa cagtgtttgc tttttcgttg 42601 gacgctgtgc ttctgtccaa atttgcgtac gttccgattc aaaaagggaa aattgttgat 42661 ttatgcaccg gcaatggtat tgtgccgctg ctgctcagta caagatcaaa agcagacatt 42721 ctgggagtcg aaattcaaga aagactgcat gatatggctg ttcgcagcgt ggagtataat 42781 aagttggacg atcagatcca gatcatacat gatgacctga aaaacatgcc ggagaaactt 42841 ggacataatc gatatgatgt tgtcacctgc aatccgccgt attttaaaac gccgaaacaa 42901 actgaacaaa acatgaacga gcatctccga atcgcaagac atgaaatcca ctgcacgctg 42961 gaggatgtca tttcagtcag cagcaagctg ctcaagcaag ggggaaaagc agctcttgtt 43021 caccggccgg gaaggcttct ggagattttt gaactgatga aggcttatca aatcgagccg 43081 aaacgtgtac aatttgtcta tccgaagcaa gggaaagaag ccaataccat tttggttgaa 43141 ggtatcaaag gcgggcgccc ggatttgaaa attcttcctc ccttattcgt atatgatgaa 43201 caaaatgaat atacaaaaga aatcaggacc attttatatg gagacaaata accatttctt 43261 ctacgtcgtg aaatgtaagg acaatagctg gtatgccggg tataccaacg atctgcataa 43321 acgagtgaaa acgcacaatg atggaaaggg cgcaaagtac acaaaagtaa gacgtccggt 43381 tgaattaatt tttgccgaga gcttttcaac aaagcgggaa gctatgcagg cggaatatta 43441 tttcaaaaaa ctaactcgga agaaaaaaga gctttatata gaagaaaagc ggaacagcaa 43501 ggaggctgta tatgttaagg cgccaaatga gctttaatgg aaagtcggac atggggattc 43561 tttacttggt cccaacccca atcggaaatt tagaggatat gacattccgg gcgatcgaca 43621 cgctgaaatc agtggatgcg attgctgcgg aagatacgag gcaaacgaaa aagctttgtc 43681 atgtatatga aattgaaaca ccgctcgtca gctatcacga acacaataaa gaaagcagtg 43741 ggcacaaaat tattgaatgg ctgaaatcgg gaaaaaacat tgctcttgtc agtgatgccg 43801 gtctgccgac gatttctgat cccggagcgg aaattgtaaa ggattttacg gatataggcg 43861 gttatgttgt tccgttgccg ggagcaaatg ctgcattaac agctcttatt gcttcaggta 43921 ttgtaccgca gccttttttc ttttacggtt ttctcaacag acagaaaaaa gaaaagaaga 43981 aggagcttga agcccttaaa aaacggcagg aaacgatcat tttttatgaa gcgccccaca 44041 gattgaagga aaccttgtca gcgatggcag agatattagg agatcgggaa attgctgtaa 44101 cacgtgaact cactaagaaa tatgaagagt ttatccgagg aaccatatct gaggtcattg 44161 gatgggcaaa cgaggatcag atacgcggcg agttttgtct tgtcgtagaa ggaagtaata 44221 atgaagaggt agatgaggaa gaacaatggt gggaaaccct cactgcgaaa gaacatgtcg 44281 agcattacat ttcgaaaggc gctacgtcta aagaagctat taaaaaagca gcagtcgatc 44341 gcaatgtacc aaagcgtgaa gtgtacgatg cttaccatat taagcaataa aaaaacgttc 44401 ttgtgtcata acaagaacgt tttttgtaca agaaatgatt atttaaggtt ttgaagctgg 44461 ttttggattt cgctgatgat ttgctcagcg ccttctttac taagaaccaa tttaccgcct 44521 gcaagtttaa ggttatcatc agaaacttca ccagttactt ggcaagtcat gtttggttta 44581 tattttttaa ggatgatttt ttcatcatca acatagattt caagagcatc tttttctgcg 44641 attccaagag tacgacgcag ttcgatagga ataactacac gtcctaattc atcaacttta 44701 cgtacaatac cagtagattt cataaacatt ctcctcccaa gagatactta tttgtttaaa 44761 ttatattttt cttcgtcatt attcgacaaa atccttacct tcatagcata acaaggtttc 44821 caataatcgt caatcatttt gtttactatt gattgtaaga attagttctt atagtcagta 44881 atgtcttgga aactaccgaa ataacagcat tttataaata tttaataaag ctattatcct 44941 actaaaaatc cttttaaatc aagactttcg aaccaaagtt ttttatttca tttgattata 45001 tacgacaaaa ttcgacacga acagactttt tttattttca ttaaagattt ttaattttaa 45061 ttattctttt tcagggcgta tgtatatatt cttgatctta aaggctaaga tggtatcata 45121 gataaaggat aaatataaat aatattcata tatgatttgc acttatcgcc gctctcgtcc 45181 tttgggcggg agctttttga cattctgatt aggaggtttc aagatgccgc aagaaaacaa 45241 tacattttac attacaacac cgatttatta tccgagcgga aaattacata tcggccatgc 45301 atatacgaca gtcgcaggag atgcaatggc acgttacaaa agattaaaag ggttcgatgt 45361 tcgctattta acgggaacgg acgagcatgg acaaaagatc cagcaaaaag ctgaacagga 45421 aaacattaca cctcaggagt atgtggatcg cgcagcggca gatattcaaa aactgtggaa 45481 gcagcttgaa atctcaaacg acgactttat ccgcacgaca gaaaaacggc ataaagttgt 45541 cattgaaaaa gtgtttcaaa agcttcttga taacggggac atctatcttg atgagtatga 45601 aggctggtac agcatccctg atgaaacgtt ctacacggaa actcagctcg ttgatattga 45661 gcggaatgaa aagggagagg tcatcggcgg aaaaagccct gacagcggtc acccagttga 45721 attgatcaaa gaggaatctt atttcttccg catggggaaa tacgcggatc gtcttctgaa 45781 atactatgaa gaaaacccga cattcattca gccagaatca cgcaaaaacg aaatgattaa 45841 taactttatc aaacctggac ttgaggattt ggcagtatca cgtaccactt ttgattgggg 45901 cgtgaaggtg ccggaaaatc caaagcatgt tgtatatgtt tggattgacg cactatttaa 45961 ctatttaacg gcactcggtt atgatacaga aaatgatgag ctttatcaaa aatattggcc 46021 tgccgatgtt catttagtcg gtaaggagat tgtacgattc catactattt actggccaat 46081 tatgctgatg gcgctggatc ttccgctgcc aaagcaagta ttcgcgcatg gctggctttt 46141 gatgaaagac ggaaaaatgt cgaaatcaaa aggaaacgtt gtagatccgg ttacattaat 46201 tgaacgctat ggtttagacg aacttcgcta ttacttgctt cgcgaagtgc cgttcggatc 46261 agacggtgtt ttcacgccgg aaggatttgt tgagcgaatc aactatgatt tagcgaatga 46321 tttaggaaat ctattgaatc gtactgttgc gatgattaat aagtattttg acggacaaat 46381 cggttcttac aaaggtgctg ttacggaatt tgaccatacg ctcacttctg ttgctgaaga 46441 aacagtgaaa gcttatgaga aagcaatgga aaatatggag ttctcggtag cactttcgac 46501 tttatggcag ctcatcagcc gcacaaacaa atacattgat gagacagctc catgggtgct 46561 tgcgaaagat ccggcaaaag aagaagaatt gcgatcagtt atgtatcatc tcgctgaatc 46621 attgcgtatt tcagcggtac tgcttcagcc attcttaaca aaaacacctg aaaaaatgtt 46681 cgagcagctg ggcattactg atgaatcttt aaaagcttgg gacagcatta cagctttcgg 46741 ccagctgaaa gatacaaaag tacaaaaagg cgagccattg ttccctcgtt tagaggcaga 46801 agaagaaatt gcttacatca aagggaaaat gcaaggttca gcaccagcga aagaagaaac 46861 aaaagaagaa gagcctcaag aggtcgatcg tttacctgaa attacgattg atcaatttat 46921 ggatgtagag cttcgcgtag ctgaggtcat tgaggcagag ccagtgaaaa aagcagaccg 46981 tttattgaag ctgcagcttg atcttggttt tgaaaagcgc caagtggtat ccggcattgc 47041 gaagcattat acgcctgaag agcttgttgg aaaaaaactc gtttgtgtaa caaatctaaa 47101 accggttaaa ctcagaggag agctttctca aggtatgatc cttgcaggag aagcagacgg 47161 cgttttaaag gtcgtatcta tcgatcagtc gttaccaaaa ggcacaagaa ttaaataatg 47221 ataaacaaaa ggtgtttcac gtgtaacaat tcgtcgaaca ccttttgtgt ttcgacaaga 47281 aaggagtttt tcacttatgt tgtttgacac tcacgcgcat ttaaatgcag aacaatatga 47341 tactgatctt gaagaggtta ttgaacgggc aaaagctgaa aaagttgaac gaattgtcgt 47401 agttggtttt gaccgtccga cgattacccg tgcgatggaa atgattgagg aatatgattt 47461 tatttatgca gccattggct ggcaccctgt tgacgctatt gacatgacag aggaagactt 47521 agcgtggatt aaagagcttt ctgctcatga gaaagtggta gcgatagggg aaatgggact 47581 ggattatcat tgggataaat cacctaaaga tattcaaaaa gaggtgttta gaaatcaaat 47641 cgccttagcg aaagaggtca atttgcctat tatcattcat aaccgtgatg caacggagga 47701 tgtcgtgacc attttgaaag aggaaggcgc agaagctgtg ggcggaatca tgcactgctt 47761 tacaggaagt gcggaagtgg caagagaatg catgaaaatg aatttttatt tatcatttgg 47821 gggaccggtg acatttaaaa atgcgaagaa accgaaggaa gtagtgaagg aaattcccaa 47881 tgaccggctg ctgattgaaa cggactgccc gtttctcaca ccgcaccctt tccgcgggaa 47941 aagaaatgag ccaagctatg tgaaatatgt ggcagaacaa atcgccgaat taaaagaaat 48001 gacctttgaa gagattgctt ccatcacgac tgaaaatgcg aaaagacttt tccgtataaa 48061 ctgacaaaaa acgctagcgg gttttgtaag agcttgtccc ttacagcgtt tttctataaa 48121 agttctacat gctttcttct cctcatagga taggtttgtc gacaagtctt tcttccgttt 48181 ctcagtgtat ttcaggataa tgaagaggac actgagcttt tgggagaaag agaagggagg 48241 gttgacagcc ttttagatac tctatataat ctctccgagg agaaggaggc gtttttcatc 48301 acacaaaaaa tgaaaaagct gttttccgta aagcttagca aaagcaaagt cattctggtt 48361 gctgcttgtt tgcttttggc aggaagcggg actgcgtacg cggctcatga gctgacgaaa 48421 caatcagtct cagtttctat caatggcaaa aagaaacata tacgcacaca tgcaaataca 48481 gtcggtgatc ttttggagac gcttgatata aagacaagag acgaagacaa gatcacacct 48541 gctaaacaga caaagataac agcagacatg gacgttgtgt atgaggctgc aaaacctgtg 48601 aagcttacaa taaacgggga agaaaagacg ttatggtcaa cagcaaaaac ggtcggtgca 48661 ttactggacg aacaagatgt tgatgtgaaa gaacaagatc aaattgatcc cgcaatagat 48721 acagatattt cgaaagacat gaagattaac atagagcccg catttcaggt tactgtgaat 48781 gatgcaggga aacaaaagaa gatctggacg acttcgacta cggtcgctga ctttttaaaa 48841 cagcaaaaga tgaacataaa agacgaagat aaaatcaagc ctgcgttaga tgcaaagctg 48901 acgaaaggaa aggctgatat tacaattact cgtatcgaaa aggtcaccga tgtagttgaa 48961 gagaagattg cgttcgatgt gaaaaagcaa gaagacgctt ctcttgaaaa agggaaagaa 49021 aaggtcgtcc aaaaaggaaa agaaggcaag ctaaaaaaac atttcgaagt cgttaaagaa 49081 aacggtaaag aagtgtccag agagcttgta aaagaagaaa cagctgaaca aagcaaagat 49141 aaagtgattg ctgtcggcac aaagcaaagc agtccaaaat ttgaaacggt cagtgcttca 49201 ggtgattcaa aaacagttgt gtcccgcagc aatgaatcaa caggcaaagt catgactgta 49261 tcatctacgg cttatacggc aagctgcagc ggttgttcag gacatacagc gacaggcgtc 49321 aatttaaaaa ataatccgaa tgccaaagtc atcgctgtgg atccaaatgt cattccgcta 49381 ggctccaaag tccacgtgga aggctatgga tatgccattg ctgcagatac cggttcagcg 49441 attaaaggga acaagataga cgtctttttc ccagagaaat catcggcgta ccgatgggga 49501 aataaaacag tcaaaattaa aatcttaaat tagtatatac ttatgtattc agagggtttt 49561 gcgccctctg tttttttcgt tataatagac aaagtgcatt ttctgcttat tagacgctcg 49621 atataagaaa aagtttcatg aatatacaaa agtttttatt ttgtcttgga ggaaataatg 49681 aaaattaaag agatcattgt ggtcgagggg cgtgacgata cggcccgcat caaattggct 49741 gttgatgcag acacaattga aacaaatggt tcagccatcg atgatcatgt gattgaccaa 49801 atccgtttgg cccagaagac gagaggcgtc attattttaa cggatccgga ctttccggga 49861 gagaagattc gcaaaaccat ctcagaggct gtacccggct gtaagcatgc atttttgcca 49921 aaacatcttg ccaaacctaa aaacaagcgg ggaattggtg tggagcatgc atcggttgaa 49981 agcattaggg catgtttaga aaatgtgcat gaggagatgg aagcgcagcc gagtgacatt 50041 tcagctgagg atttgattca tgccggacta ataggcgggc ctgcggccaa atgccgccgg 50101 gaacgactgg gtgatctgtt gaaaatcggc tatacaaatg gcaaacagct tcaaaaacgg 50161 ctgcaaatgt ttcaaattaa aaaaagtgat tttatgagtg cgctcgatac cgttatgcgg 50221 gaggaacaga atgaataaag atattgcgac accgattaga acgaaagaga tactgaagaa 50281 atacggtttt tcttttaaaa agagcttagg acagaatttc ttaattgata cgaacatttt 50341 aaacagaatt gttgatcacg cggaagtgac ggagaaaaca ggtgtcattg aaatcggccc 50401 gggaatcggg gctttaaccg aacagcttgc caagcgggcg aaaaaggtcg tggcatttga 50461 gattgaccag cgattattgc cgattctgaa ggatacactg tcaccttacg aaaatgtcac 50521 tgtcattcat caggacgtgt taaaggctga tgtcaaatca gtcattgaag aacaatttca 50581 agattgtgat gagatcatgg tagttgccaa ccttccttat tacgtaacaa caccgattat 50641 catgaaactg cttgaagaac atcttccgct gaaagggatt gtggttatgc tgcaaaaaga 50701 agtggctgag cgcatggcgg ctgatccttc atctaaggaa tacggctcgc tttcaatcgc 50761 ggtgcagttt tatacagaag ccaaaacggt gatgatcgtc ccgaaaaccg tatttgttcc 50821 tcagcctaat gtcgattccg cagtcattcg tctgattctc cgagacggcc cggcagtgga 50881 cgtggaaaac gaatcctttt tctttcagct catcaaggca agctttgcac agcgccgtaa 50941 aacgctgctc aataacttag ttaacaatct gcctgaagga aaagcacaaa aatcaacgat 51001 tgaacaagtg ctcgaagaaa caaatattga cggtaagcgc cgaggtgaat ccctgtctat 51061 tgaggaattc gcagcgctgt ctaacggatt gtataaagcc cttttctaaa agggcttttt 51121 gttttgcgca ccacatggac tgccgctaca taggctagag aaggaccttt cattcaatga 51181 taagaaaaaa cttggactca gcgaaaaaag gcgctttctc aaggctcttt ctttcatgat 51241 gaggcttagt ctatgtgtgg agtgaggaac gtgcaatttc aaatagggga tatggtagcc 51301 agaaaatcct atcagatgga tgttttgttt cgaattatag gaatagagca aacaagcaaa 51361 ggaaattcaa ttgccatttt gcatggagat gaagtcaggc tgattgctga ttcggatttt 51421 tctgatctgg tggcagtgaa aaaggatgag cagatgatgc ggaaaaagaa agatgagagc 51481 agaatgaatg agtcgctcga attgctccgc caagattata agctgctcag agaaaagcag 51541 gagtactatg cgacaagcca atatcagcat caggagcatt atttccatat gccgggcaaa 51601 gtgcttcatc tggatggtga cgaagcatat ttgaaaaaat gcctgaatgt ctataaaaaa 51661 attggagtgc cggtctatgg catccattgc catgaaaaga aaatgtctgc ttctattgaa 51721 gtattgctcg acaaatatcg acctgacatc ctggtgatca cagggcatga tgcgtactcg 51781 aagcaaaagg gcggtattga tgatttgaat gcgtacagac attctaagca ctttgttgaa 51841 acagttcaaa cagcccgaaa aaagatccct cacttagatc agcttgttat ttttgcgggg 51901 gcctgccaat cccattttga atcactcatc agagcgggtg cgaattttgc aagttcaccg 51961 tcaagagtca atattcatgc gcttgatccg gtatatatcg tcgcgaagat cagctttacg 52021 ccgtttatgg aacggattaa tgtatgggaa gtgctccgta atacgctgac aagagagaaa 52081 gggcttggag gtattgaaac aagaggagtt ctgagaattg gtatgcctta taagtccaat 52141 taacagttga aaacctgcat aggagagcta tgcgggtttt ttattttaca taatgataca 52201 taatttaccg aaacttgcgg aacataattg aggaatcata gaattttgtc aaaataattt 52261 tattgacaac gtcttattaa cgttgatata atttaaattt tatttgacaa aaatgggctc 52321 gtgttgtaca ataaatgtag tgaggtggat gcaatggcga agacgttgtc cgatattaaa 52381 agatcgcttg atgggaattt aggtaaaagg ctgacgttaa aagcaaacgg tggccgccga 52441 aaaacgattg agcgttcggg cattttagct gagacgtacc cttctgtttt tgtgatacaa 52501 ctagatcaag acgagaactc gtttgaaaga gtttcataca gttatgctga tattttgact 52561 gagactgttg agctgacatt taatgatgac gccgcaagct cagtggcatt ttaacgggca 52621 gtgaaccttt tgtttactgc tttttgtttt gccctttttt ggtttccaat aattttaacg 52681 aaagttccat ctgatttaac aaaagataaa acagtcacat attatcgtga cgtgcacgaa 52741 tggctatcac ttctaaaaaa ggagttgttt cgtttgggca gacgtcgtgg agttatgtca 52801 gatgagttta aatatgagct ggctaaagac cttggttttt atgacacagt aaaaaatgga 52861 ggctggggtg aaattcgggc ccgcgatgcc ggtaacatgg tgaagcgtgc tattgaaatc 52921 gccgaacagc aaatggctca gaatcagaat aaccgataag gatgtgaccc gggggacgtg 52981 ctgttccctg gtttttttat tttggatata aatacataat gggctgaata tggatatgtt 53041 catcctgtac ttcaaatgtg atacaatgtt catacttatg tttagatgga gaagtaggtg 53101 aaagctatgc gtattttaga aaaagcgcca gctaagatca atctgtcact tgacgtcacc 53161 cgaaaacgcc cggatggcta tcatgaagtc gaaatgatca tgacgacaat tgatttagct 53221 gatcgaattg aattgacgga gcttgcagag gatgaagtga gggtttcctc ccacaaccga 53281 tttgtgcctg atgaccaaag aaacttagct tatcaggctg ccaagctgat caaggacaga 53341 tacaacgtga aaaagggagt ttccatcatg attacgaagg taattccggt ggctgccggt 53401 cttgccggcg gaagcagtga tgcggcggcg acactcagag ggctgaacag actgtggaat 53461 ttaaatctgt ccgcggaaac gcttgctgag cttggagcgg aaattggctc tgacgtttca 53521 ttttgtgtct atggcggaac tgcattagca acagggcgcg gcgagaaaat taaacatatc 53581 agcacgcctc cgcactgctg ggtcatttta gcgaagccga caatcggtgt ttcaactgct 53641 gaagtgtaca gagcgctgaa actggatggt atagagcatc ccgatgtaca aggcatgatc 53701 gaggcgatag aagaaaagag ttttcagaag atgtgcagcc ggttaggcaa tgtgcttgaa 53761 tctgttacac tcgatatgca tcctgaagtt gcgatgatca aaaaccagat gaaacgcttt 53821 ggtgcagatg ccgtgttaat gagcgggagc ggcccgacag tgtttggact ggttcagtat 53881 gagtcgaagg tgcagagaat ttataacggg ttaagaggct tctgcgatca agtttatgcg 53941 gtgagaatga tcggcgaaca gaacgctctt gattaaatcc gtatgttaag ttatattgat 54001 cttaaaatat tcggattttg ggggtgagtt catgaagttt cgtcgcagcg gcagattggt 54061 ggacttaaca aattatttgt taacccatcc gcacgagtta ataccgctaa cctttttctc 54121 tgagcggtat gaatctgcaa aatcatcgat cagtgaagat ttaacaatta ttaaacaaac 54181 ctttgaacag caggggattg gtactttgct tactgttccc ggagctgccg gaggcgttaa 54241 atatattccg aaaatgaagc aggctgaagc tgaagagttt gtgcagacac ttggacagtc 54301 gctggcaaat cctgagcgta tccttccggg cggttatgta tatttaacgg atatcttagg 54361 aaagccatct gtactctcca aggtagggaa gctgtttgct tccgtgtttg cagagcgcga 54421 aattgatgtt gtcatgaccg ttgccacgaa aggcatccct cttgcgtacg cagctgcaag 54481 ctatttgaat gtgcctgttg tgatcgttcg taaagacaat aaggtaacag agggctccac 54541 agtcagcatt aattacgttt caggctcctc aaaccgcatt caaacaatgt cacttgcgaa 54601 aagaagcatg aaaacgggtt caaacgtact cattattgat gactttatga aagcaggcgg 54661 caccattaat ggtatgatta acctgttgga tgagtttaac gcaaatgtgg cgggaatcgg 54721 cgtcttagtt gaagccgaag gagtagatga acgtcttgtt gacgaatata tgtcacttct 54781 tactctttca accatcaaca tgaaagagaa gtccattgaa attcagaatg gcaattttct 54841 gcgttttttt aaagacaatc ttttaaagaa tggagagaca gaatcatgac aaaagcagtc 54901 cacacaaaac atgccccagc ggcaatcggg ccttattcac aagggattat cgtcaacaat 54961 atgttttaca gctcaggcca aatccctttg actccttcag gcgaaatggt gaatggcgat 55021 attaaggagc agactcatca agtattcagc aatttaaagg cggttctgga agaagcgggt 55081 gcttcttttg aaacagttgt aaaagcaact gtatttatcg cggatatgga acagtttgcg 55141 gaagtaaacg aagtgtacgg acaatatttt gacactcaca aaccggcgag atcttgtgtt 55201 gaagtcgcga gactcccgaa ggatgcgtta gtcgagatcg aagttattgc actggtgaaa 55261 taataagaaa agtgattctg ggagagccgg gatcactttt ttatttacct tatgcccgaa 55321 atgaaagctt tatgacctaa ttgtgtaact atatcctatt ttttcaaaaa atattttaaa 55381 aacgagcagg atttcagaaa aaatcgtgga attgatacac taatgctttt atatagggaa 55441 aaggtggtga actactgtgg aagttactga cgtaagatta cgccgcgtga ataccgatgg 55501 tcgcatgaga gcgattgcat ccatcacgct ggatcacgaa tttgttgtac atgatattcg 55561 tgtgattgat ggaaacaatg gtcttttcgt tgcgatgccg agtaaacgca cccctgatgg 55621 agagttccgc gatattactc atcctattaa ttcaagcacg cgaggaaaga ttcaagatgc 55681 cgtgttaaat gagtatcatc gtctgggtga cactgaagca ttagaattcg aagaagctgg 55741 agcttcttaa aaaataacca aaaagcaagg actgctgaaa gggctgacat aagccttttg 55801 ccggcggtcc ttttttaatt ctgatttttc aaacttagtt gcactcaata gaaaattctt 55861 gcacttcatg aagtctcctt gaaatcagaa gatatttagg atatattttt ctatggataa 55921 aagggatatt ggaggccaat aaatggataa gcggtttgca gttgttttag cggctggaca 55981 aggaacgaga atgaaatcga agctttataa agtccttcat ccagtttgcg gtaagcctat 56041 ggtagagcac gtcgtggacg aagccttaaa attatcttta tcaaagcttg tcacgattgt 56101 cggacatggt gcggaagaag tgaaaaagca gcttggtgat aaaagcgagt acgcgcttca 56161 agcaaaacag cttggcactg ctcatgctgt aaaacaggca cagccatttc ttgctgacga 56221 aaaaggcgtc acaattgtca tttgcggaga tacgccgctt ttgacagcag agacgatgga 56281 acagatgctg aaagaacata cacaaagaga agcgaaagct acgattttaa ctgcggttgc 56341 agaagatcca actggatacg gccgcattat tcgcagcgaa aacggagcgg ttcaaaaaat 56401 agttgagcat aaggacgcct ctgaagaaga acgtcttgta actgagatca acaccggtac 56461 gtattgtttt gacaatgaag cgctatttcg ggctattgat caggtgtcta atgataatgc 56521 acaaggcgag tattatttgc cggatgtcat agagattctt aaaaatgaag gcgaaactgt 56581 tgccgcttac cagactggta atttccaaga aacgctcgga gttaatgata gagttgctct 56641 ttctcaggca gaacaattta tgaaagagcg cattaataaa cggcatatgc aaaatggcgt 56701 gacgttgatt gacccgatga atacgtatat ttctcctgac gctgttatcg gaagcgatac 56761 tgtgatttac cctggaactg tgattaaagg tgaggtgcaa atcggagaag atacgattat 56821 tggccctcat acggagatta tgaatagtgc cattggcagc cgtacggtta ttaaacaatc 56881 ggtagtcaat cacagtaaag tggggaatga tgtaaacata ggaccttttg ctcacatcag 56941 acctgattct gtcatcggga atgaagtgaa gatcgggaat tttgtagaaa ttaaaaagac 57001 tcaattcgga gaccgaagca aggcatctca tctaagctat gtcggcgatg ctgaggtagg 57061 cactgatgta aacctgggct gcggttcaat tactgtcaat tatgatggaa agaataagta 57121 tttgacaaaa attgaagatg gcgcgtttat cggctgcaat tccaacttgg ttgcccctgt 57181 cacagtcgga gaaggcgctt atgtggcggc aggttcaact gttacggaag atgtacctgg 57241 aaaagcactt gctattgcca gagcgagaca agtaaataaa gacgattatg tgaaaaatat 57301 tcataaaaaa taatcctaaa ttcggaggtt tatccatgtc taatcaatac ggagataaga 57361 atttaaagat tttttctttg aattcgaatc cagagcttgc aaaagaaatc gcagatatag 57421 ttggagttca attagggaaa tgttctgtca caagatttag tgacggggaa gtccaaatta 57481 atatcgaaga aagtattcgc ggatgtgatt gttacatcat ccagtctaca agtgaccccg 57541 ttaacgagca tattatggaa ctgctgatta tggtagatgc gttaaaacgc gcttctgcaa 57601 aaacgattaa cattgttatt ccttattacg gttatgcgcg tcaagacaga aaagcaagat 57661 cccgtgagcc aatcacagct aaacttttcg ctaacctgct tgaaacagcc ggtgcgactc 57721 gtgtgattgc acttgacctg catgcgccgc aaattcaagg attctttgat ataccgattg 57781 accacttaat gggtgttccg attttaggag aatattttga aggcaaaaat cttgaagata 57841 tcgtcattgt ttcaccagac catggcggtg tgacacgtgc ccgcaaactg gctgaccgac 57901 taaaagcgcc aattgcgatt atcgataaac gccgtccgcg tccaaacgtg gcggaagtca 57961 tgaatattgt aggtaacatc gaagggaaga ctgctatcct catcgatgac attattgata 58021 ctgcaggtac gattacactt gctgctaatg cgctcgttga aaacggagcg aaagaagtat 58081 atgcatgctg tacacaccct gtactatcag gccctgcggt tgaacggatt aataattcaa 58141 caattaaaga gcttgttgtg acaaacagca tcaagcttcc tgaagaaaag aaaattgaac 58201 gctttaagca gctttcagtc ggaccgcttc tggccgaagc gattattcgc gttcatgagc 58261 agcaatcagt cagctatctg ttcagctaaa ccatttttcg aggtttaaat ccttatcgtt 58321 atgggtattg tttgtaatag gacaactaaa acgacaagag gatggtgctg aatatggcaa 58381 ctttaacggc aaaagaaaga acggacttta ctcgttcgtc tcttcggaat atccgtactt 58441 caggacatgt tccaggtatc atatatggga aggatacggg taacaaacct gtgtcattag 58501 acagtgtgga gctcatcaaa acgctgaggg acgaaggcaa aaatgcagtc attacgcttg 58561 aggtcagcgg agaaaaacac tcagtcatgg taacagacct gcagacggac ccgctgaaaa 58621 atgaaatcac tcatgctgat tttcaagtag ttaatatgag tgaggacatt gaagtggaag 58681 ttccgattca tctgaccgga gaagccattg gagtgaaaaa cggaggcgta ctgcagcagc 58741 cgttatatgc acttactgta aaggccaagc caaaagccat tccgcaaacg attgaggctg 58801 atatttcaag cctcgatgta aatgaagtac tgacgattgc ggatttgcct gctggcggtg 58861 actactcctt taatcatgaa tcagatgagg ttgtggcttc aatccttcct ccgcagcagc 58921 aggaagcagc tgaggtcgat gaagaggaat ctgccgatgc tcagcctgaa ggtgaaaacg 58981 aacaataata gcttaaggcg taaccctccc gcggttacgt cttttgtgct agaatgagaa 59041 gaattatagc ccgtttatga agacgggagt tatgtgacta agggaggatt cgccatgctt 59101 gtgattgccg gtctcggaaa cccggggaag aactatgaaa atacacggca taatgtcgga 59161 tttatggtga tagatcagct tgcaaaggaa tggaatatag agctgaatca aaataaattt 59221 aacggattat acggaaccgg atttgtttcc ggcaaaaagg ttctacttgt taaaccgctt 59281 acatatatga atttatcagg agaatgtttg cggcctttaa tggactacta tgatgtcgat 59341 aacgaagatt tgacagtcat ttacgacgac cttgaccttc cgactggcaa gatccgttta 59401 agaacgaaag gaagcgccgg agggcacaat ggcatcaaat cactgatcca gcatcttgga 59461 acgtccgagt ttgaccgtat ccgcatcgga atcggccggc ctgtaaacgg catgaaggtc 59521 gttgattatg tgttaggctc ctttaccaag gaggaggcac ctgagatcga agaagcggtt 59581 gataaatctg tgaaggcttg tgaggcttct ttgagtaaac cgtttttaga agtcatgaac 59641 gaatttaacg caaaggtata aaatgtaaca acaaagtcca tactacacca aaatgacttt 59701 ttcatcagga ggacccttgt atggctttgc attattattg tcgtcattgc ggagtgaaag 59761 taggcagtct cgaatcttca atggtatcga cagactcact tggatttcag cacttaacaa 59821 atgaggaaag aaacgatatg atttcttata aagaaaatgg agatgtccat gttttgacga 59881 tatgtgaaga ctgccaagag gcgcttgacc gaaatccgca ttaccacgaa tatcacacat 59941 ttattcaata aaaagctttg gtgtagacac tagaccaaag cgtttttctg ttctcgcagg 60001 aaacagagag gaggggccat atggacaaca ttcaaacctt tataaaagaa agcgatgact 60061 ttaaatccat catcaacggt ttacacgagg gcctgaagga acagctgctc gcgggtctgt 60121 cgggttccgc gcgttctgtt tttacttctg ctctggctaa tgaaacgaat aagcctatct 60181 ttctcatcac ccataactta tatcaagccc agaaagtaac agatgatctg acttcacttc 60241 tagaggatcg gtctgtcctt ttgtaccccg tcaatgaact catttcatca gaaatcgcag 60301 ttgcaagccc tgaattgcgg gcgcagcgat tagatgtcat taatagacta acgaatggag 60361 aagcgccaat tgtcgttgct ccggtagctg caatcagaag aatgctgccg cctgttgagg 60421 tgtggaaaag cagccagatg ctcattcaag taggccatga tattgaacct gaccagcttg 60481 cctcacggct ggtagaggta gggtatgagc ggtctgatat ggtttctgcg cccggggaat 60541 tcagtattcg cgggggaatc attgacattt atccgctgac ttcagagaat ccggtgagaa 60601 ttgaactttt tgacaccgag gtggattcaa tccgcagctt taattcagat gatcagcggt 60661 caattgagac ccttacctcg atcaatatcg gtcccgcgaa ggaattaatt atcagaccgg 60721 aagaaaaagc gcgggcgatg gagaaaatcg atagtggtct tgccgcgagc ttgaaaaaat 60781 taaaggctga caaacaaaaa gaaatacttc atgcgaatat ttctcacgat aaagaacgct 60841 tgtctgaagg ccagacagat caggagctcg tgaagtatct ctcatatttc tatgaaaagc 60901 ctgctagttt actagattat acacctgata atacacttct gattttggat gaagtcagtc 60961 ggattcatga gatggaagaa cagcttcaaa aagaagaagc ggagtttata acaaatcttc 61021 ttgaggaagg gaagattttg catgacattc gtttgtcatt cagcttccaa aaaatagtgg 61081 ctgagcaaaa acggcctctg ctgtactact ctttattttt gcggcatgta caccatacga 61141 gcccgcaaaa tatcgtcaat gtgtcaggcc ggcaaatgca gagtttccat ggccaaatga 61201 acgtgcttgc gggcgaaatg gagcgtttta aaaaatcaaa tttcactgtt gtgttcttag 61261 gagcaaacaa ggaacgtacg cagaaattgt catctgtttt ggctgattat gatatcgagg 61321 ccgccatgac agacagcaaa aaagcgcttg ttcagggaca ggtctatatc atggaaggcg 61381 agctccaatc gggatttgag ctgccgttaa tgaagcttgc cgttatcacg gaagaagaac 61441 tgttcaaaaa ccgtgtaaag aagaagccgc gaaaacagaa gcttaccaat gcagagcgca 61501 tcaaaagcta ttctgagctt caaattggag attatgtcgt tcatattaat cacgggatcg 61561 gaaaatacct ggggattgaa actcttgaaa tcaacggcat tcataaagac tatttaaata 61621 tacattatca gggcagtgac aagctttacg tccctgtaga acaaattgat caggtccaaa 61681 aatatgttgg ctccgaagga aaagagccaa agctgtataa attaggcgga agtgaatgga 61741 agcgggtcaa gaaaaaagta gagacatccg ttcaggatat tgctgatgac ttaattaagc 61801 tgtatgccga aagagaagcg agcaagggct atgcgttttc tcctgaccat gagatgcagc 61861 gtgaattcga atcggctttc ccttatcaag agactgagga tcagctccgt tctattcacg 61921 aaatcaaaaa agacatggaa agagaacgtc cgatggaccg cttgctgtgc ggagatgtgg 61981 gctacggtaa aacagaggtt gccatacgtg ccgcgtttaa ggcgatcggt gacggaaagc 62041 aggtagctct gctcgttccg acaaccattt tggcacagca gcactatgaa accataaaag 62101 agcgcttcca ggactatccg attaatatcg gccttctcag caggttcaga acgagaaaag 62161 aagcaaacga aacaatcaaa gggctgaaaa atggaacggt tgatatcgtc atcgggacgc 62221 atcggctgct atcaaaggat gtcgtgtata aagacttagg gctcctcatc attgatgaag 62281 agcagcgttt cggtgtaacc cataaagaaa agatcaagca aataaaagcc aatgttgatg 62341 tattaacgtt aacagcaacg ccgattccgc gtacgctgca tatgtctatg cttggcgtaa 62401 gggacctttc agtcatcgag actccgccgg aaaatcgctt ccccgtacag acgtatgttg 62461 tggaatataa cggcgctctt gtcagagagg cgattgaacg tgagcttgca cgcggaggcc 62521 aggtctattt cttgtacaac cgggtagagg acattgagcg gaaagcggat gaaatttcaa 62581 tgctagtccc tgacgcgaag gtagcatatg cgcatgggaa aatgacagaa aatgaattag 62641 aaaccgttat gctaagcttc cttgaaggag aatcagacgt tctcgtcagc acaaccatta 62701 tcgaaactgg cgtggacatc ccaaacgtca atacgctgat cgtatttgac gccgacaaga 62761 tgggactttc tcagctttac cagctgcggg ggcgtgtcgg ccgttctaac cgtgtggcgt 62821 atgcgtactt cacgtatcgc cgggataaag tgctgacaga agtggctgaa aaaaggctgc 62881 aggctattaa agaattcaca gagttaggtt ccggttttaa aatcgcaatg cgtgacttaa 62941 cgattcgcgg agccgggaat cttcttggtg cccagcagca tggcttcatc gattcggtcg 63001 gatttgacct ctattcacaa atgctgaagg aggccattga ggagcgtaaa ggagacacag 63061 cgaagacaga gcagtttgaa acagaaattg atgtcgagct tgatgcgtat attccggaaa 63121 cttatattca agacggcaaa cagaaaattg atatgtataa acgcttcagg tctgtggcga 63181 caatcgaaga gaagaatgag cttcaagatg aaatgatcga ccgctttgga aactatccaa 63241 aagaagtcga atacttgttt actgttgcag aaatgaaagt ctatgcgaga caggaacgtg 63301 tcgagctgat taagcaggat aaagatgctg tcagattgac gatttctgaa gaagcaagtg 63361 ctgaaattga cgggcagaag ctgtttgagc ttggcaatca atatggcaga caaatcggac 63421 tgggaatgga agggaaaaaa ctcaaaatct ccatacagac gaaaggccgt agtgctgatg 63481 aatggctcga caccgtgctg ggcatgctga agggcttaaa agatgtgaaa aagcaaacca 63541 tttcatcaac gtaaattttg ttactctctg gtgtatatta catttgatgt gacggatact 63601 aatttcaagc gaggcggaag gtacataaag taactgcttt aggtctttcc cacatgtata 63661 taccatcaaa tgaaagagag gcaccagaga tgaaagcaac cggtatcgta cgtcgtattg 63721 atgacttagg tcgggtcgtg attcctaaag aaattcgaag aactctgaga atcagggaag 63781 gcgatccgct tgagattttt gtagatcgtg acggagaagt gattttgaaa aagtactctc 63841 cgatcagtga gcttggagac tttgcaaagg agtatgcaga cgcgctttac gacagcctcg 63901 gccattcagt gctgatttgt gatcgtgatg tatatattgc cgtgtccggc agctccaaaa 63961 aagattactt aaacaagtca atcagcgaaa tgctggaaag aacaatggat cagcgcagct 64021 ccgtgcttga gagtgatgcg aaatcagtac agcttgtgaa tggaattgat gaggacatga 64081 attcttatac tgtaggccca attgtggcga acggtgatcc gataggtgct gtggtgatct 64141 tttcaaaaga tcagacaatg ggcgaagtag agcataaagc cgttgaaaca gcagctggat 64201 ttttggctcg tcaaatggaa cagtaggtct tattcctttc ttcgaaaata ggtatgtaaa 64261 gaacagctct ccttgggacg ctgttctttt tcatgcgtgc cgaaaaagga atccaagggt 64321 tgggatgtgg tataataacc tcgtttttat ttgtgccgcg gtaatacgtg aaccgtattg 64381 cccctgacgt tgggaaggag cttttggatg gacgattcaa taggcgttaa acggcattgg 64441 atttggcagg gggcttttgt tttaattctg gcaggcgtca tcacaaaaat tttaagcgct 64501 gtttacagag tcccgtttca aaacattgtc ggcgatgttg gattttatat atatcagcag 64561 gtatacccct ttcttggtat tgcggtcatg ctgtccacat caggatttcc agtcattatt 64621 tcaaagctga tgaatgatta tagtgaaaaa aatcatcaca ccatattaaa aatatcagcg 64681 ttgtttttgt ctttaatcgg tattttatta tttctttgtt tatatctggg tgctgttcct 64741 attgcactct ttatgggaga ttcgcatcta gccgtgttaa ttcaagtggc cgcatacgcg 64801 tttctgcttt tcccatttgt cgcgttgcta agaggcggtt ttcaggggcg gcacgaaatg 64861 ctcccttcag ccttatcaca gatgacagag cagtttctgc gtgttgcggt gctcttgggt 64921 ttatcatttt ggctcgtgaa aaagggagcc tcgctttata ctgcgggagc ggcagccgct 64981 tcaggctctc ttgccggaag tttggttgca ttgataatac tggggttttt ttggttcaaa 65041 acgaaaagag acaaccaaac ggataggcaa aacgaaaatg tcatcacaac aaaagaattg 65101 acgaaaaaac tgcttttata ttcggtcaca atttgtgtaa gcagtttgct gcttttgttt 65161 atccagcttg ttgatgcttt gaatttatat gcattgcttt cgggtggtga ggcaagcgaa 65221 gaagcaaaat gcctaaaggg gatctatgat cggggacaac ccttgttgca gctcggttca 65281 gtttttgccg taagcattgc gacgtcactc gttccgtata tttctatggc tgtaaaaaac 65341 aaagagctga agatcatgaa agaaaaaatc acgtcatctt tgaaactatg ccttgtgctc 65401 ggtacaggcg catcggctgg gttgatttgc attctaaagc cggtaaatat catgctgttt 65461 caaaatggag aagggacagg tgcgttacaa gtatttagct gctccatttt gtttgcatcc 65521 ttggcggtaa cggcagcggc agtcttacag ggagcgggat acacagtttt tcctgcgata 65581 gcggtgggcg cgggtgttgc ggtgaaatgg gtgttaaaca cacttttggt tccgcgctat 65641 gggattgaag gcgcatcgct tgcgacagcg gcttcctttg cggctgtcgc cggccttaac 65701 ttgtatcagc ttcggcaaaa ggaatggctc gataagctta gaggcgtttt gattccgatt 65761 attggatctg ctcttttgat gtcagctgtt ttgcttgcgt atacgcgtct ctggactttc 65821 ttgtttcctg caacaggaag aggagcggct gtgattgaga gtctttctgc tgttgccatt 65881 ggtggcgcgg tgtttattta ttgtatgatg agattgggaa tatttacaga tgaagagctg 65941 aacagtgtgc cattcggcag caagttaagc aaattcatga gaaggagaga acaaaatggc 66001 gggtaaaatt acagtcgtcg gacttggtgc cggagacatg gaccaattga caattggtat 66061 acacaagctg ctgacgaagg cagatacgct gtatgtcaga accaaggatc atcctttaat 66121 tgaggagctt gaaaaagaaa cgaagaacat ccgtttcttt gatgatatat atgagaaaca 66181 tgatcagttc gaggcggtat atgaagaaat tgcagatatc ctctttgaag cggcgcggcg 66241 tgaggacgtg gtttacgctg tgccgggaca cccttttgtc gcagaaaaaa cagttcagct 66301 gctgacggag cggcaggaaa aggaaaacgt tcaagtgaaa gtcgcggggg gacaaagttt 66361 ccttgatgcc acattcaatg tcttgcaaat tgacccgatt gaaggttttc aatttgtgga 66421 tgccggcaca ttgtccgcgg atgagcttga gctcagacat catctgatca tatgtcaggt 66481 ttacgaccaa atgacggctt ctgaagtcaa gctgacattg atggagaagc tgcctgatga 66541 ttatgaggtc gtcattgtga ctgcagcagg cagccgtggc gaggagatca ggacagtgcc 66601 attatttgag ctggaccgca atgtcgcttt gaacaactta acaagtgtgt atattccgcc 66661 gattaaagaa gagaagctgc tttatcacga attctccacg ttccgaagca tcatcagaga 66721 gcttcgcgga cctaatggat gtccgtggga taaaaagcag acgcatcagt cattaaagca 66781 gtacatgatt gaagaatgtt atgagcttct cgaagctatt gacgaagaag acacagacca 66841 tatgatcgaa gagcttggcg acgttttgct tcaggtcttg cttcacgcgc aaattggtga 66901 agatgaaggt tatttcacaa ttgatgatgt cataaaagga atcagtgaaa aaatggtccg 66961 aagacatccc catgtgttta aagatgttaa ggttcaggat gaaaacgatg ttttagccaa 67021 ttgggaagat ataaaaaagg ccgaaaaaaa tacatctgaa tcatcattac tagacagcgt 67081 accgaaaacc cttccagctc tttcgaaagc agctaaattg cagaaaaaag cagcgaaggt 67141 cggttttgac tgggaagacg tcagcgatat ttgggaaaag gtaagtgagg aaatgaagga 67201 attttcttct gaggtttctg aagctcctca cgaacacaat cttaaagctg agtttggcga 67261 cattttgttc gcgctggtga atgtagcccg cttctacaaa atagagccag aggaagcgct 67321 gaccatgact aatgacaaat tccggagacg gttctcgtac attgaggaaa cagcgaagga 67381 agagggagtc gagttggctg atatgtccct tgaggacatg gacaaactgt ggaatgaagc 67441 aaaagaaact gagaggagat catagatatg agattagata aatttttgaa agtatcacgg 67501 ctgatcaaac ggcgtacact agcgaaggaa gtagctgacc aaggacgaat ctctattaac 67561 ggaaaccaag ctaaagctag ctctgacgta aaaccgggag atgaactaac ggtccgcttc 67621 ggccaaaagc ttgtaacggt tcaagttaat gaattgaaag acacgacgaa aaaagaagaa 67681 gctgcaaaca tgtacacgat tctaaaagaa gaaaaactcg gcgaataggc ttgttctaaa 67741 aaaacccccc acctcataca atgcagtaat aatgctaaaa gtatcgagga tatgggggct 67801 gaatagatga attcatatta tgatcaaaaa ggttcttcgt ctgttccgga acagcatgat 67861 gtgacaatga aaggccggaa gcatttagat atttctgggg ttaagcatgt ggagagtttt 67921 gataacgaag aattcctgct ggaaacggtg atgggaatgc tctccgtcag aggccaaaac 67981 ctgcagatga aaaatcttga tgtggaaaaa gggattgttt cgattaaagg cagggtattt 68041 gatttagtgt acttagacga acaacaaggg gataaagcta aagggttttt tagcaagttg 68101 tttaaatgac gctgacgaca caattctata caatgctagc gatgtccggt atgggtctct 68161 ggcttggtgc ttcgcttgat acataccggc tctttgtcat tcgtgccaaa acagccagat 68221 ggctattatt tattcatgat attcttttct ggattatgca agggctgctt ttcttttatg 68281 tcttgcttca tgtaaatgag ggagaattca ggatttacat ctttttagcg gttctgctgg 68341 gcgttgcgac gtatcagagc ctttgcaaac gaatctatat aaaaatactg aaattcgtca 68401 tttaccttgt tgtttctgtt tatcaattct tcaaaaaact cattcagcac gtgttatttc 68461 gtcctattgt gtggacatgc ggagcgatca tctggctggc ggcattttta ttcaagaaaa 68521 catacagcct gataggtttt ctcctgctgt gtctatataa aatagtcatg gttctgtgtt 68581 ttccgatccg ttttatcgcg aaacaatgtt tgaaacttct tcctgtgaaa atgcgtctaa 68641 cttttagacg ttattttgaa aaaggtgcag gatttctcaa aaagaagaag aaactattga 68701 taaccataag aacgaccatc acacggtttt tgaagagatg aaaggaggac cgtctggttt 68761 gaatttttcc agggaacgaa cgataactga aatacaaaac gactataaag aacaagtaga 68821 acggcaaaat cagctgaaga aacgaagacg caaagggctg tacagacggt taactgtatt 68881 cggcgcccta gtattcctga cggcaattgt gctggcaagc tctgtatggt cccaaacatc 68941 ttcccttagt gcaaaagaag aaaagaaaga acagcttgaa aaagaactga aaagtttaaa 69001 gacaaaacaa acggatttaa aagaagaaat atccaaattg aaggatgagg attacgtcac 69061 agagcttgcc agaagggact tattcatgtc tggagacgga gaaattatct tcaatgtgga 69121 gaagaagagc aagtagcctt gttgacactt aaatttttat ttaggtataa ttaagcaaac 69181 gatcttttta taagcctaag gaggagcact ttttttatgt cgattgaagt tggcagcaag 69241 ttgcaaggga aaattacagg tattacaaat tttggagcat ttgttgaatt gcctggaggc 69301 tcaaccggtc tcgttcacat tagtgaggta gctgataatt atgtcaaaga cattaacgac 69361 cacttaaaag tcggcgacca agttgaagtg aaagtcatca acgttgaaaa agacgggaaa 69421 attggtttat ctattaaaaa agctaaagac cgtccgcaag ccagacctag aaatgatttc 69481 cgtccgaaag aatcttttga acagaaaatg aataagtttt taaaagacag cgaagatcgc 69541 ttgtcatctt taaaacgcaa tacggaatca aaacgtggag ggcgcggagc aagaagagga 69601 taacttgctg ctttctataa aataaatgaa gcatccgttc atcccgacgg atgctttttt 69661 attatcctca ttctctttaa gagtcagaaa attacaacat taaagtttct gttgacgaaa 69721 gagacaaacc tttgtattat ataacttgtg cttagaagca caaaacaata tggcggtgta 69781 gctcagctgg ctagagcgta cggttcatac ccgtgaggtc gggggttcga tcccctccgc 69841 cgctaccata tttgtttggc ccgttggtca agcggttaag acaccgccct ttcacggcgg 69901 taacacgggt tcgaatcccg tacgggtcat cctaacaaat cggtttctct tgcagaagcc 69961 gatttttttc atttttagac aacattccgg aaattctttt cataaacgaa tatcaaggca 70021 gaaaccgtcg aagatttctt tggtattgtt accttctttt gacaaaatcc tatctgtgct 70081 ttcgctataa tgacaggcaa cgaatataac aggtgggaga tgagaggaat ggaaaaagca 70141 gaaagaagag tgaacgggcc aatggcggga caagctttgg aaaaactcca atcgtttttt 70201 aacaggggca cgaagctggt gactcatcat ttgcattcac tgtttttcta taaaggattc 70261 atttatgttg tcatcggatt tttgcttgga cgggctttca tattatccga ggtgcttcct 70321 ttcgcacttc ctttctttgg agcgatgctt cttatcagaa gagacaaagc gttttatgcg 70381 gttttggctg tgcttgcagg tgcgctgacc atatctccaa agcactcatt gctcatactg 70441 gcggcattgc tggcattctt cgtattttct aaagtggctg ccttcattac cgacgatcgt 70501 gttaaagcgc tcccgattgt cgtgttcttc tccatggctg cagcaagagc cgggtttgtt 70561 tatgcccaaa atggcgtatt tacaacctat gattatgtaa tggctatcgt tgaggctgga 70621 ctatcgttta tcttaacact gattttcctt cagagccttc cgatttttac tgtgaaaaaa 70681 gtgaaacaat cattaaaaat agaggaaatc atttgcttta tgattcttat tgcctctgtt 70741 ttaacggggc tggctggctt gtcctaccaa gggatgcagg cagaacatat attggctcgt 70801 tatgttgtgt tgagtttttc ctttattggc ggagcaagca tcggctgtac ggttggggtt 70861 gtgaccggcc tgattcttgg cttggcgaat atcggaaacc tatatcaaat gagtctgctt 70921 gctttttccg gtttattggg cggtttgctg aaggaaggga aaaaagcggg tgcagcaatt 70981 ggtttgatcg ttggatcact tcttatatct ttatatggtg aaggctctgc cggtctgatg 71041 acaacgctct atgagtcatt aatcgcagtc tgcctgtttt tgctcacacc tcaatctatt 71101 acgaggaaag tggcgagata tattccggga actgtcgagc atcttcaaga gcaacagcaa 71161 tacgctagaa aaatccgtga tgtcactgct cagaaggtag accaattctc caatgtattt 71221 cacgcgctgt ctgaaagctt tgcaaccttt tatcaagcat cagacgaaca gacagatgac 71281 agcgaagttg atctgttctt aagcaaaatc acggagcatt cctgccagac gtgctacaag 71341 aaaaacaggt gctgggtaca gaactttgat aaaacatatg acttaatgaa acaagttatg 71401 cttgaaacag aggaaaaaga atatgcatca aaccgaaggc tgaaaaaaga gtttcaacag 71461 tattgttcta aatccaagca ggttgaagag ctgattgagg atgagctcgc acatcatcat 71521 gcccatttga cactcaagaa aaaagtccaa gacagcaggc gccttgttgc tgaacagctt 71581 ttaggcgttt ctgaggttat ggccgacttt tctcgggaaa taaaaagaga gcgagaacaa 71641 cactttctgc aggaagagca aatcatagaa gcgcttcagc atttcggaat tgagattcag 71701 catgtcgaga tctatagtct tgaacaagga aatatcgata ttgaaatgac cattccgttc 71761 agcggacatg gagaaagtga aaaaatcatt gctcctatgc tttctgacat tctggaggaa 71821 caaattcttg tgaaagccga acagcactct ccgcatccga atggatacag ccatgtcgcc 71881 tttggatcaa caaaatcata cagggtgtcc acgggagctg ctcacgctgc gaagggcggc 71941 ggccttgtct ccggtgacag ctacagcatg atggagcttg gagccagaaa atatgctgca 72001 gcaatcagtg acggaatggg caatggcgca agagcgcact ttgaaagcaa tgaaacgatc 72061 aagcttcttg aaaaaatcct tgaatcgggc attgatgaaa aaatagcaat taaaacgatc 72121 aacagcatac tgtctctaag gacaactgac gaaatatatt ccacgcttga cctatctatt 72181 atcgatcttc aagatgccag ctgtaaattt ttgaaggttg gatcgacgcc cagctttatc 72241 aaacggggtg accaggtcat gaaagttcaa gcgagcaatc tgccaatcgg tattattaat 72301 gaattcgatg tggaggttgt gagtgaacag ctgaaagcgg gtgacctctt aattatgatg 72361 agtgatggca tttttgaggg gcctaagcat gtggaaaatc acgacttatg gatgaagcgt 72421 aaaatgaaag ggttgaaaac aaatgacccg caggagattg ccgatttgct tatggaagaa 72481 gtcatccgca caagatccgg ccaaattgag gacgatatga ctgttgttgt cgtccggatt 72541 gatcacaata caccgaagtg ggcatccatt cctgttccgg caatctttca aaacaaacaa 72601 gaaatttcat aacgcttccg tataaatcaa atttcttctg gcgaagatgg gaatatatga 72661 atctgagaat cctcgtattc tccaggagga atgaatgtga acaacggaca tttaaatcaa 72721 attttgctga taacggatgg ctgctcaaac catggggaag acccgcttgc aatggctgct 72781 tttgctaaag agcaggggat tacggtaaat gtcattggta taatggaaga aaatcaaatt 72841 gaccctgagg caatgaagga agtcgaaggg attgcacttg ccggaggagg cgtgcaccaa 72901 gtcgtttatg catctcagct ttcacaaact gttcaaatgg taacaaagaa agcgatgacg 72961 caaaccttac aaggtgtagt caatcaagaa ctgaaacaga ttctcggaaa gaatgtggaa 73021 atggaagagc tttctccgga aaaacgcggc gaagtcatgg aagtggtaga cgagcttgga 73081 gaaacggtgc atcttcaggt tttggttctt gttgatacaa gtgcaagtat ggcgccaaag 73141 cttccaacag taaaagaggc gctgattgat ttgtctgtaa gcctcaattc ccgaattggg 73201 aataacgaat ttgcgatgtg tatatttccc gggaaaaaac aagaggtcga gcttgtgctg 73261 aactggacac cgaagctgca atctctttcc acactctttg caaagctttc gacaggcggc 73321 atcacgccga caggtccggc gattcgtgaa gcgacactgc agtttgaaaa aatacgctca 73381 agaaggggca tgctggcaga tgatgaacga cgctttgacg agtttggcat gtagcctcaa 73441 gccgggtacg acaatcaaag gcaagtggaa tggaaacact tatacattgc gtaaacagct 73501 tggtaaaggg gccaatggaa ttgtgtattt ggcagaaaca tcagatggac atgttgcctt 73561 aaaggtgagt gatgacagcc tgtctattac ttctgaagtg aatgtcttga aatctttctc 73621 aaaggcccag tccgttacga tggggccttc tttttttgat acggatgatg cctatattcc 73681 cagtgccaat acgaaagttt cattttatgc aatggaatac ataaaagggc cgctgctttt 73741 gaagtatgtc agtgataaag gagcagagtg gataccggta ttaatgattc agctgttatc 73801 cagcttatcg gtgcttcacc agcaaggatg gatattcggc gatcttaaac ctgataatct 73861 gatcgtaact ggtccgcccg caaggatccg ctgcattgat gtgggcggca cgacaaagga 73921 aggccgggcg ataaaagagt atacggagtt ttatgacaga ggctattggg ggtatggaac 73981 aagaaaggca gagccatcct atgatctgtt cgcagttgcc atgattatga tcaacagtgt 74041 gcataaaaaa gaatttaaga aaacgaacca gcccaaagaa cagcttaggt ctctcatcga 74101 aggaaacccg ctgcttcaaa agtataaaaa agcgcttttt tcagccttga acggagatta 74161 tcaatccgca gatgaaatga aaaaggatat gctagacgcg gggcaaaaag cagcacaaag 74221 aaaacagcct ataaaagcat caccgcagcc tgccacacga caaagacagc aaaaaccgcg 74281 ccaaggaaaa ataacgaaga cgcgatatac cccaaaacag aaaccggcta agtcgggggg 74341 gttatttgaa acaacgctta tcgtgatcag tgttttagcg ctttatttcg cctatattat 74401 ctttttctta atctgaatgg tgcaaactgc agagcctatg cttcttcttt gcttggaggg 74461 gttgaaagtg ttaggatatg aatatcttta aaatacctgc tcattgtgag gaggacattg 74521 tgaaaagtgt caaagatttt ttaaacaaac acaatcttac gttaaaaggg gcgacaatca 74581 ttgtaggcgt ttccggcggt ccggactcaa tggctcttct tcacgcgttg catacgttat 74641 gcggccgttc agcgaatgtt attgcagctc acgttgacca tcggttcaga ggtgcggaat 74701 ccgaggagga catgcgtttt gtccaagctt attgtaaagc tgaacagctc gtgtgcgaaa 74761 cggctcaaat caatgtaacc gcatatgcac aggaaaaagg actcaataag caggctgcag 74821 cacgcgattg ccgctaccag ttttttgagg aaatcatgtc gaagcaccaa gcggactatc 74881 tggctcttgc gcatcatggt gatgaccagg ttgaaacaat gcttatgaaa ctggctaagg 74941 gtacgcttgg aacgggactt gcgggaatgc agccggttag acgttttggg acagggcgga 75001 tcatcaggcc gttcttaacc attacaaagg aagagatcct tcactattgc catgaaaacg 75061 gcttgagcta ccggacggat gaaagcaacg ccaaagatga ctacacaaga aacagattca 75121 gaaaaacagt gctcccgttt ttgaagcagg aatctccgga tgtgcataaa aggtttcaga 75181 aagtgagtga agcactgacg gaagatgagc aattcttaca gtcattaacg aaagatgaaa 75241 tgaataaagt aatcacaagc cagtctaata catcagttga aatcaattcc tctcaattgc 75301 ttgccctccc gatgccttta caaagaagag gagttcaact aatattaaac tatctttatg 75361 aaaacgttcc atcatccttt tcagcccatc acattcagca gtttctcgat tgggcggaaa 75421 atggcggtcc ttcaggagta ctggactttc cgaaagggct gaaggtggtc aaatcatatc 75481 agacatgttt gtttacattt gaacaatggc agtgcaaaaa tgttcccttt gaataccaaa 75541 ttagcggagc tgctgatgaa acggcagtgc tccctaatgg atatctgata gaggcaaggc 75601 attatgcgga ctcgcctgaa gaacatggga atgctgtttt tatcacaagt gaaaaaaagg 75661 tgcgatttcc cttaacaatc cggacgagaa aagctggaga ccggatcaaa ctaaaaggga 75721 tgaacggctc aaaaaaggta aaggatatat ttattgataa gaaattgcct ctccaagaaa 75781 gagacaactg gccgattgtg acggacgcaa gcggtgaaat tatctggata cctggcttga 75841 aaaaatcaat ttttgaagat cttgtgattc caaacagcga ccgcattgta ttacaatata 75901 gacagcatga aaagtgtagg gggcaagcaa aatcatgatg aaacatgata tcgagaaagt 75961 actgatctca gaggaagaga tacaaaagaa agtaaaagag ttaggtgcag aattaacgag 76021 cgagtatcaa gatacatttc cgttggcaat cggtgtgtta aaaggagcac ttccttttat 76081 ggcggatctt atcaagcata ttgatacata tttggaaatg gatttcatgg atgtatcaag 76141 ctacggaaat tctacggttt cttctggaga agtaaaaatc attaaagatt tggatacatc 76201 tgtagagggc cgggacatct taattattga agatatcatc gacagtgggt taaccttaag 76261 ttatctcgta gagctcttcc gataccgtaa agcaaaatca attaagattg ttaccctttt 76321 ggataaaccg agcggaagaa aagcggacat caaagcagac tttgtcggtt ttgaagttcc 76381 tgacgcgttt gtagtgggtt acggacttga ttatgctgag cgctatcgca atctgcctta 76441 tatcggagtg ttaaaaccgg cagtttatga aagctgatcg gcagcctgct tccgagatgg 76501 ttattgtttg tattggaatg attttctatg gtactattga acatagttgt gcttactgtg 76561 ggaggaggta aggaatgaat cgggtcttcc gtaataccat tttttattta cttattttat 76621 tagtagtaat cggggttgtg agctacttcc agacctcaaa tccgaaaaca gaaaatatgt 76681 cgtacagtac gttcatcaaa aacctggatg acgggaaagt tgatagcgta tcggttcagc 76741 ctgtcagagg tgtttatgag gtaaaagggc agctgaaaaa ctacgacaaa gatcaatact 76801 ttttgactca tgttcctgaa ggaaagggag cagaccagat atttaacgct ttgaaaaaga 76861 cagacgtaaa ggttgagccc gcgcaagaaa caagcggatg ggtgacgttc ctgacgacca 76921 tcatcccatt tgtcattatc tttattctgt ttttcttcct gctcaatcag gctcaaggcg 76981 gcggcagccg tgtcatgaac tttggcaaga gtaaagcgaa gctgtataca gaggaaaaga 77041 aacgcgtcaa atttaaagac gttgcagggg ctgacgaaga aaagcaagaa cttgttgaag 77101 ttgttgagtt tctgaaagat ccccgcaagt ttgccgagct cggcgccaga ataccgaaag 77161 gcgtgctttt agtcggacct ccgggtaccg gtaaaacatt gcttgccaag gcttgtgcag 77221 gagaagccgg cgtacctttc ttcagcatca gcggatctga tttcgttgaa atgtttgtag 77281 gggtcggtgc ttcccgtgtg cgtgacttgt ttgaaaatgc gaaaaagaat gcgccttgtt 77341 tgatcttcat tgatgaaatt gacgcagtcg gacgccagcg tggcgctggt ctcggcggtg 77401 gacacgatga acgtgaacag acgctaaacc aattgcttgt tgaaatggac ggattcagcg 77461 ctaatgaagg aattatcatc attgctgcga cgaaccgtgc ggacatcttg gacccagcct 77521 tacttcgtcc gggacgtttt gaccgtcaaa tcacagtgga ccgcccagat gtcattggcc 77581 gtgaagctgt attgaaagtc catgcgagaa acaaaccgct ggatgaaacg gttaacctaa 77641 aatcaattgc catgagaaca ccaggcttct caggcgctga cttagaaaac ctcttgaatg 77701 aagctgcgct tgtagcggct cgtcaaaaca agaaaaaaat cgatgcgcgt gatattgacg 77761 aagcgacgga ccgtgtaatt gccggacccg ctaagaagag ccgcgttatc tccaagaaag 77821 aacgcaatat cgtggcttat cacgaaggcg gacacaccgt tatcggtctc gttttagatg 77881 aggcagatat ggttcataaa gtaacgattg ttcctcgggg ccaggctggc ggttatgctg 77941 ttatgctgcc aagagaagac cgttatttcc aaacaaagcc ggagctgctt gataaaattg 78001 tcggcctctt gggcggacgt gttgctgaag agattatctt cggtgaagtc agcacagggg 78061 cgcacaatga cttccagcgt gcgacgaata ttgcaagacg aatggttaca gaattcggta 78121 tgtcagaaaa actgggaccg ttgcaatttg gacagtctca gggcggtcag gtattcttag 78181 gccgtgattt caacaacgaa cagaactaca gtgatcaaat cgcttacgaa attgatcagg 78241 aaattcagcg catcatcaaa gaatgttatg agcgtgcgaa acaaatcctg actgaaaatc 78301 gtgacaagct tgaattgatt gcccaaacgc ttctgaaagt tgaaacgctt gacgctgaac 78361 aaatcaaaca ccttatcgat catggaacat tacctgagcg taatttctca gatgatgaaa 78421 agaacgatga tgtgaaagta aacattctga caaaaacaga agaaaagaaa gacgatacga 78481 aagagtaatt cgctttcttt ctaaaaaaac tgccggctga cgctggcagt ttttttatgt 78541 aaatgattgg ctcagctgcg gcttttacaa tcatccaatt ctggtatcga tttgtttaca 78601 aatgagccgc tgatcgtgta tggtattgta gaatgtttgt aaaaagtaaa gtagagaaac 78661 tattcaaaag tggtgataga ggttgttact ggttatcgat gtggggaaca ccaatactgt 78721 acttggtgta tatcatgatg gaaaattaga atatcactgg cgtatagaaa caagcaggca 78781 taaaacagaa gatgagtttg ggatgatttt gcgctcctta tttgatcact ccgggcttat 78841 gtttgaacag atagatggca ttattatttc gtcagtagtg ccgccaatca tgtttgcgtt 78901 agaaagaatg tgcacaaaat actttcatat cgagcctcaa attgttggtc caggtatgaa 78961 aaccggttta aatataaaat atgacaatcc gaaagaagta ggggcagaca gaatcgtaaa 79021 tgctgtcgct gcgatacact tgtacggcaa tccattaatt gttgtcgatt tcggaaccgc 79081 cacaacgtac tgctatattg atgaaaacaa acaatacatg ggcggggcga ttgcccctgg 79141 gattacaatt tcgacagagg cgctttactc gcgtgcagca aagcttcctc gtatcgaaat 79201 cacccggccc gacaatatta tcggaaaaaa cactgttagc gcgatgcaat ctggaatttt 79261 atttggctat gtcggccaag tggaaggaat cgttaagcga atgaaatggc aggcaaaaca 79321 ggaaccaaag gtcattgcga caggaggcct ggcgccgctc attgcgaacg aatcagattg 79381 tatagacatc gttgatccat tcttaaccct aaaagggctg gaattgattt atgaaagaaa 79441 ccgcgtagga agtgtatagg aggtttagta atggattatt tagtaaaagc acttgcgtat 79501 gacggaaaag ttcgggctta tgcagcgaga acgactgata tggtaaatga ggggcagaga 79561 cgccatggta cgtggccgac agcatccgct gcactaggcc gtacaatgac agcttcactt 79621 atgctcggcg ctatgctgaa gggcgatgat aagctgaccg tgaaaatcga gggcggaggt 79681 ccgatcggag ctattgtagc tgatgccaat gccaaaggag aagtcagagc ctatgtctct 79741 aacccgcaag ttcattttga tttaaatgaa caaggtaagc ttgatgtcag acgtgcggtt 79801 ggaacaaacg gaacgttaag tgtcgtaaaa gatttaggtt tgcgcgagtt cttcacagga 79861 caagtagaaa tcgtttcagg agaattagga gatgatttta cttactatct tgtgtcatct 79921 gagcaggttc cttcatcagt gggcgtaggt gtgctcgtaa atcctgacaa taccattctt 79981 gcggcagggg gctttattat tcagctgatg ccgggaacag atgatgaaac aatcacaaaa 80041 attgaacagc gtctatctca agtagagccg atttctaagc tcatccaaaa agggctgaca 80101 ccagaagaaa ttttagaaga agtcctaggc gagaaacctg agattttgga aacgatgcct 80161 gtcagattcc attgcccttg ttcaaaagaa cggttcgaaa cagccatttt aggactaggc 80221 aaaaaagaaa ttcaagatat gatagaagaa gatggacaag ccgaagcagt atgccatttt 80281 tgtaatgaaa agtacttatt tacaaaagaa gagctggaag ggcttcgtga ccaaactacc 80341 cgctaagctc tttagcgggt ttttaatttg agaaaagggg ctgaaagcag gtttgaaatc 80401 aagaacaatc tggaccatta ttttaggggc gctgttggtt tgctgtattg ctgttgcata 80461 tacgctgacg aaatcccaag ccggcgcatc gtcatccggt gagtctattg cgactatcgg 80521 aggcaagagt gtgacaagag aagaatggct gaaagaaatg gaagatcagt atggtaagtc 80581 aacgcttgaa gatatgatca atgtccgagt tgttgagcag ctggctaaaa agaacaaact 80641 taaaatatcc aaaagcgaag ttgatcgtga gtttttgctg attaaagcgg tcaataattc 80701 cttttacgaa gatgaacata cgacggagaa agagtggaaa gaccaaattc gttataatat 80761 cctccttgag gatttgttaa caagggatat cgatatctca aacaaagaat tggaatcatt 80821 ctataataaa aataaggaac tatatcagtt tgatgattcg tatcgaattc ggcacattgt 80881 tgtaaaagat gaagaagaag caagagaagt cctgaaagaa ctgaaaggcg gatcaagctt 80941 tgaagctgtc gctgccgaaa gatctacaga cagatataca tcaccatacg gcggagattt 81001 aggttttgtc acagaggcat cagacaacat tccatcagca tacattgaag aggcgaaaac 81061 actcaaagag gatgaatggt ctcaggaacc aataaaggtc agcaacggat atgccattat 81121 ccagctgaaa gaaaaactaa aggcaagaac gttctcattt gatgaagtaa aggaccagat 81181 cagacggcaa atcgcaatgg atcagctagg cgataaagcg acagttaaga cactttggaa 81241 agaagccgat gtatcttggt tttatgggga aaaaagtact aagtgattga caaaaaattt 81301 tgaaattgat agattatata cataatacca atacaaatag tcggaaattg aggtgtcgag 81361 aatggtacgt gtagcaaact ccattactga attaattggg aatacgccaa tcgttaaatt 81421 aaatcgcctt gcagatgaaa acagtgcgga tgtatatcta aaacttgaat acatgaaccc 81481 tggaagcagt gtaaaagacc gtatcggttt agctatgatt gaagcggctg aaaaagaagg 81541 aaaattaaaa gccggtaata caatcattga accgacaagc ggaaatactg gaatcgggct 81601 tgcaatggtt gctgctgcta aaggattaaa agccattttg gttatgcctg atacaatgag 81661 catggagcgc cgcaaccttc ttcgcgcata tggtgctgag cttgtgctga ctcctggtgc 81721 ggaaggcatg aaaggtgcta ttaagaaagc tgaagagctt gctgaaaagc acggatactt 81781 tgtgccgcag cagtttaaca acccttctaa ccccgaaatt caccgccaaa caacgggtaa 81841 agaaatcgtt gagcaattcg gtgatgatca gcttgacgca tttgtagccg gaatcggaac 81901 gggcggaacg attacgggag cgggcgaagt gctgaaggaa gcataccctt ccatcaagat 81961 ttatgctgtt gaaccgtcag attccccagt gctttcagga ggaaaaccag gcccccacaa 82021 aattcaggga atcggagcag gattcgtgcc ggacatctta aacactgaag tatatgatga 82081 aatcttccct gtgaagaatg aagaagcatt cgaatatgcc cgcagagctg cacgtgaaga 82141 aggaattctc ggaggcatct catcaggtgc ggcaatttat gctgctcttc aagtagcaaa 82201 aaaactcgga aaaggcaaaa aagtattggc catcattcca agtaacggcg aacgttatct 82261 aagcacgccg ctgtaccaat tcgattaaaa aaagccaaaa ctcccggttc gccgggagtt 82321 tttttatatt tcgtgcatca aatatgccat gtctgcgacg aatgttattc ttggaagaga 82381 aattcacttt tttcactaac aacattgctt tacaattaaa aacaagtaaa aaagaaaata 82441 gaggaatgat acaaatggca caacgcagac cggcaggcaa aaaaatacct tttcaaaaag 82501 actcattctt acaacaattt gagaaacttg cgcaatcccg gaaacatcat gtacttctcg 82561 aaagtgcaag aggcggcaga tatagtatag ccggtcttga tccaattgcg actgtgaaag 82621 gaaaagacgg aataactaca attaagcatg gtgatgagat gctgtttaaa gaaggtgatc 82681 cattacgggc cttccacagc tggtttaaaa cactggaaac agaaacgaat catgagttcc 82741 ctgactttca aggcggggca atcgggtttc tcagctatga ttacgcacgg tacattgaaa 82801 attttaaaat gctctcatta gatgatttag aaacaccaga tatttatttt cttgtttttg 82861 atgatatagc agtttatgac catcaagaag agtctctatg gctgattact catgttaatg 82921 gttctgatca ggaaacagcg gatgtgaagc tatctgagtt agagcagatg tggttgactg 82981 agcttcccgc tgtcacttcg cgagagatga agcctgaaac agctggttct ttcgcggcgc 83041 catttaccga ggatgggttc tcacaagctg tagagaaaat caaacaatac attgccagcg 83101 gagatgtgtt tcaagtcaat ctatcaataa ggcagtcaca gtcactgtct gtccacccat 83161 atcaaattta caaaaccttg agagaagtaa atccttctcc ttatatggcg tatttagaaa 83221 cacctgattt ccaaatcatt tgcggatcgc ctgaactgct tgtcagcaaa aagggcaagc 83281 tattagagac gagaccgatt gcgggcaccc gttccagagg gaaaacaaat gaagaagacg 83341 aggcgcttgc aaacgaattg atacacaatg aaaaagaacg cgcggaacat gtcatgctgg 83401 ttgatcttga gcgaaatgat ctgggaagag tatcacgtta cgggtctgtg cgcgtaaatg 83461 aattcatggc aattgaaaaa tactcgcatg tgatgcacat tgtgtctaat gtccaaggtg 83521 aactgcagga tgggtatgat gctgtagata ttattcatgc tgtgtttccc ggaggaacca 83581 ttactggtgc accgaaagta agaacgatgg aaattataga agaacttgag ccgacacgcc 83641 gagggcttta tactggatct ataggatggt ttggatataa tcacgatctg cagtttaata 83701 tcgtcattcg aaccatttat gcaaccggag ggcaggcatt tatgcagtcc ggtgcaggag 83761 ttgtgattga ttctgttccg aagcacgaat acaaggaatc attcaaaaaa gcttttgcga 83821 tgcaaagagc attagagctg agcgaagaag agacaaaaat tagatgaggt gagcggagaa 83881 atgattttaa tgattgataa ctacgattca ttcacgtaca acttggtaca gtatttgggc 83941 gagcttgggg aagagctggt tgtgaaacgc aatgacagca tcacaatcga tgaaattgaa 84001 gaactgtctc cggactttct gatgatatct cccggaccgt gcagccctga tgaggcggga 84061 atcagcctcg aagcaattaa acatttcgca gggaaaattc ctattttcgg tgtatgtctc 84121 ggacatcagt ccatcgcaca agtgttcggt ggtgatgttg ttagggcaga acggcttatg 84181 cacgggaaaa cctcggatat cgagcatgac ggcaaaacca tttttgaagg gttgaaaaat 84241 ccccttgttg cgacgcgata ccactcgctg atcgtaaaac ctgagacgct gccaagctgt 84301 tttacagtaa cagcacaaac gaaagaagga gaaatcatgg ctattcgcca caatgacctc 84361 ccgatagagg gtgtgcaatt tcacccagag tctattatga cctcctttgg gaaagaaatg 84421 ctcagaaatt ttattgagac atatcgcaag gaagttattg cgtgatgata tatgtgaacg 84481 gccggtatat ggaggagaaa gatgcagttc tttctccttt tgaccatggg tttttatatg 84541 ggatcggtgt tttcgaaacc ttcaggctct acgaaggctg cccgtttttg cttgattggc 84601 atatagagag gcttgaacgc gcgcttaagg atctgcaaat cgaatatact gtttcaaagc 84661 atgagatcct tgagatgctg gacaagctgc ttaagctaaa tgatatcaag gatggcaatg 84721 cccgcgtcag actgaacata tcagcgggaa tcagcgataa aggctttgtc gcccagacgt 84781 acgataagcc caccgtttta tgctttgtga atcagctgaa accagaaagt cttcctttgc 84841 aaaaagaagg aaaggtttta tcgatacgga gaaacactcc agagggatcg ttccggttaa 84901 aatctcatca ttatctaaat aatatgtatg cgaaacggga aattggaaat gatccgcgtg 84961 tcgagggaat tttcttaacg gaggatggag ctgttgcaga gggtatcata tctaatgtct 85021 tctggagaaa aggtcgctgt atctatacgc catcgcttga taccggtatt ctggacggcg 85081 tcacgagacg ttttatcata gaaaatgcaa aggatatcgg cctggagctc aaaacgggcc 85141 gatatgagct agaagctctc ttgacagctg acgaagcgtg gatgacgaac tcggttcttg 85201 aaatcatccc gtttactaaa atagaagaag taaactatgg aagccaaagc ggagaagcaa 85261 cctccgctct tcaattgtta tacaaaaaag aaataaagaa catgattcat gaaaagggag 85321 gaagagcatg gcgcagcaca caatagatca aacacaagta atccacacta agcccagcgc 85381 tttatcatat aaagagaaga cgctggtgat gggaatttta aacgtaacgc ctgactcttt 85441 ctcggacggc ggaaaatatg acagcttgga caaggcgctg ctgcacgcga aagagatgat 85501 cgatgatggt gcccatatca ttgatattgg aggggaatcg acaaggcctg gcgctgagtg 85561 cgtatctgag gatgaggaga tgtccagagt cattccggtg attgagcgga ttacgaaaga 85621 gcttggtgtt cctatttctg tagacacgta caaggcttct gtcgcagatg aagcagtgaa 85681 agccggtgca tccattatca atgatatttg gggagccaaa catgatccga agatggcttc 85741 cgttgcagct gaacataatg ttccaattgt actcatgcat aaccgccctg aaagaaacta 85801 caatgactta ttgccggata tgctgtcgga cttaatggag agtgtaaaaa ttgctgttga 85861 ggccggagta gacgagaaga acattattct tgatcctggt atcggtttcg cgaaaaccta 85921 tcacgataac ttggcagtga tgaacaaact agagattttc agcggattgg gatatccggt 85981 tcttctggca acctcccgaa aaagattcat cggacgtgtt ctggatcttc cgcctgagga 86041 gcgggctgag ggcacaggcg cgactgtgtg tctcggcatt caaaaaggct gtgacattgt 86101 cagggtccat gatgtaaagc aaattgccag aatggcgaaa atgatggacg cgatgctgaa 86161 taagggaggg gtgcaccatg gataaagttt atgtagaagg tatggagttt tacggatatc 86221 acggtgtgtt cacagaagaa aacaaacttg gccagcggtt taaagtcgat ttaaccgctg 86281 agctggattt aagcaaagct ggacagacag acgaccttga gcaaacgatc aactatgctg 86341 agctctatca cgtatgtaaa gatatcgtgg aaggggagcc tgtgaaattg gtggaaacgc 86401 tggcggaacg tattgctggc actgttctcg gaaaatttca gcctgttcag caatgtacgg 86461 tgaaagtgat taagccagac ccgccaattc ccggacacta taaatcagta gcaattgaaa 86521 ttacgagaaa aaagtcatga acaacatagc ttatattgca cttggatcta atattggaga 86581 tagagaaacg tatttaaggc aagcagtggc tttactgcat cagcatgctg cggtgacagt 86641 cactaaagtg tcgtctattt acgaaactga cccggtcgga tacgaagatc aagctcaatt 86701 tttgaatatg gctgttgaaa tcaagacatc attgaaccct tttgaactcc ttgaactgac 86761 gcagcagata gaaaatgaat taggcagaac aagggaagta agatgggggc cgcggacggc 86821 agaccttgac attttgttat ttaatcgtga aaatattgaa acagagcaac taattgttcc 86881 gcatccgaga atgtatgagc gtttgtttgt ccttgcgccg cttgcggaaa tttgccagca 86941 ggttgaaaaa gaggctacaa gcgccgaaac agaccaagaa ggtgtaagag tatggaagca 87001 gaaatctggg gtagacgaat tcgtgcattc agaaagctga aaggttatac tcaagaagga 87061 tttgcaaaag cattaggtat atcagtttct attctcggcg aaattgaacg cggaaaccga 87121 ttgccgtctg ctgccatcat tcaagatgca gcagatgttt taaatataag tgcggacgaa 87181 ttggcgccgc cagaaaaata gaacaaatga aaggaggaga aaaattgttc aaaatcggag 87241 atattcaatt gaaaaaccgg gttgtgctcg cacctatggc tggtgtctgc aactctgcgt 87301 tcagattgac tgtaaaggaa ttcggagccg gattggtatg cgctgaaatg gtcagtgaca 87361 aagcgatcct ttacaacaat gcaagaacaa tgggtatgct ttatattgat gaacgtgaga 87421 aaccactgag ccttcaaatt ttcggaggaa aaaaggaaac ccttgtggaa gcggcgaagt 87481 ttgtagacca aaacacaact gctgatatca ttgatattaa catgggatgt cccgtgccga 87541 agattacaaa atgcgatgcg ggagccaaat ggcttctcga tcctgataag atttacgaaa 87601 tggtttctgc agtagtggat gctgttaata agccagttac agtgaaaatg agaatgggct 87661 gggatgaaga ccacattttc gcagtgaaaa atgcacaggc tgtagaacgt gcgggcggta 87721 aagcagtggc gcttcacggc cgtacgagag tgcagatgta cgaaggaacg gcaaactggg 87781 atatcatcaa agaagtaaaa caatcagtat cgattccggt tatcggaaac ggcgatgtta 87841 agacaccgca ggatgctaag cgtatgctcg atgagacagg agtagacggg gtcatgatcg 87901 gacgcgctgc attgggtaac ccgtggatga tttaccgtac ggttcagtat cttgaaacag 87961 gtaaattaaa agaagagccg caagtacgcg aaaaaatggc cgtatgcaaa ctgcatcttg 88021 accgcctgat tgacttaaaa ggtgaaaacg tagcggtaag agaaatgaga aagcacgctg 88081 catggtatct gaaaggcgtg aaaggcaatg cgaacgttcg taatgaaatc aatcattgcg 88141 agacgagaga agagtttgta cagcttttag atgcatttac ggttgaagtt gaggcaaaag 88201 agcttcaaaa tgcaaaagta ggataatact cacctctatt tgctgctcac tgctagtttt 88261 acgctggcag tttttctgct tttttcatga aacaatatct gtaatggagt gataacaatg 88321 agtcaagaag agcataacca tgaagaattg aatgatcagc tgcaagtcag acgcgataaa 88381 atgaatcagc tgagagataa cggcatcgat ccattcggcg cacgttttga aagaactcat 88441 cagtctcaag aagttatttc ggcatatcaa gatctaacca aagaagagtt agaagaaaaa 88501 gcgattgaag ttacaatcgc aggccgcatg atgacaaaac gcggcaaagg aaaagccggc 88561 tttgcccatc ttcaggattt agaaggccaa atccaaatct acgtaagaaa agacagtgtc 88621 ggtgacgacc aatatgaaat cttcaagtct tctgacctcg gtgatcttat cggcgtaacc 88681 ggaaaagtct tcaaaacaaa tgtaggcgaa ttgtctgtta aagcaacttc ctttgaattg 88741 ctgacaaaag cgcttcgtcc gcttcctgac aaataccatg gtttaaaaga cgttgagcag 88801 cgctaccgtc agcgctatct ggatcttatc gtaaacccag acagcaaaca tacgttcatt 88861 acacgaagca agatcattca agctatgaga aggtaccttg atgatcatgg atacttagaa 88921 gtagaaacac ctacaatgca cagcattcct gggggagctt ctgcacgtcc gtttatcact 88981 caccacaacg cgttagacat tccactctat atgcgtattg ctatcgaact gcacctaaaa 89041 cgtctaattg tcggcggttt agaaaaagta tatgaaatcg gccgtgtttt ccgtaacgaa 89101 ggtgtctcta cacgccataa ccctgaattt acaatgattg agttatatga agcatatgcg 89161 gactataaag atatcatgag cttaactgaa aaccttgtcg ctcatatcgc ccaagaagtg 89221 cttggcacaa ctacgattca atacggggaa gagcaaatcg accttaaacc ggagtggaaa 89281 agaatccata tggttgacgc agtcaaagaa gcgaccggcg ttgatttctg ggaagaggtt 89341 actgttgagc aggcgcgtga atatgcaaaa gaacatgaag tagaaattaa agactctatg 89401 acagtaggcc atatcatcaa cgaattcttc gaacaaaaaa ttgaagaaac gcttattcag 89461 ccaacgttta tttacgggca tcctgtagaa atttctcctc ttgctaagaa aaaccctgag 89521 gacccgcgtt ttacagaccg ttttgagctg tttatcgttg gccgtgaaca tgccaacgcg 89581 tttacagagc tgaatgatcc tattgatcaa agagaacgct ttgaagcgca attaaaagag 89641 cgtgaagccg gtaatgatga agctcattta atggatgaag actttgttga agctctggaa 89701 tacggtatgc cgccaacagg aggtttaggc atcggtatcg accgtctggt tatgctgctg 89761 acgaatgccc cttctattcg cgatgtgctg ttattcccgc aaatgagaca acgctaataa 89821 aaaagagcgg tatcctccat agggaaagga tgccgctctt tttaaatccc ttagtatttc 89881 ttcaaaaaaa ctattgcact attatttact aggtggtata ttattattcg ttgccgctaa 89941 acaaggcgat aacgaaaaaa agaacttcaa aaaaagttat tgacttcact gagtcaacga 90001 gttataataa taaagtcgct tgaacgaagt gaacaaaatg atctttgaaa actaaacaag 90061 acaaaacgta cctgttaatt cagtttttaa aaatcgcaca gcgatgtgcg tagtcagtca 90121 aactacttta tcggagagtt tgatcctggc tcaggacgaa cgctggcggc gtgcctaata 90181 catgcaagtc gagcggacag atgggagctt gctccctgat gttagcggcg gacgggtgag 90241 taacacgtgg gtaacctgcc tgtaagactg ggataactcc gggaaaccgg ggctaatacc 90301 ggatggttgt ttgaaccgca tggttcaaac ataaaaggtg gcttcggcta ccacttgcag 90361 atggacccgc ggcgcattag ctagttggtg aggtaatggc tcaccaaggc aacgatgcgt 90421 agccgacctg agagggtgat cggccacact gggactgaga cacggcccag actcctacgg 90481 gaggcagcag tagggaatct tccgcaatgg acgaaagtct gacggagcaa cgccgcgtga 90541 gtgatgaagg ttttcggatc gtaaagctct gttgttaggg aagaacaagt gccgttcgaa 90601 tagggcggta ccttgacggt acctaaccag aaagccacgg ctaactacgt gccagcagcc 90661 gcggtaatac gtaggtggca agcgttgtcc ggaattattg ggcgtaaagg gctcgcaggc 90721 ggtttcttaa gtctgatgtg aaagcccccg gctcaaccgg ggagggtcat tggaaactgg 90781 ggaacttgag tgcagaagag gagagtggaa ttccacgtgt agcggtgaaa tgcgtagaga 90841 tgtggaggaa caccagtggc gaaggcgact ctctggtctg taactgacgc tgaggagcga 90901 aagcgtgggg agcgaacagg attagatacc ctggtagtcc acgccgtaaa cgatgagtgc 90961 taagtgttag ggggtttccg ccccttagtg ctgcagctaa cgcattaagc actccgcctg 91021 gggagtacgg tcgcaagact gaaactcaaa ggaattgacg ggggcccgca caagcggtgg 91081 agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac atcctctgac 91141 aatcctagag ataggacgtc cccttcgggg gcagagtgac aggtggtgca tggttgtcgt 91201 cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tgatcttagt 91261 tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga ggaaggtggg 91321 gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta caatggacag 91381 aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc tcagttcgga 91441 tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg atcagcatgc 91501 cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga gagtttgtaa 91561 cacccgaagt cggtgaggta accttttagg agccagccgc cgaaggtggg acagatgatt 91621 ggggtgaagt cgtaacaagg tagccgtatc ggaaggtgcg gctggatcac ctcctttcta 91681 aggatatttt acggaatata agaccttggg tcttataaac agaacgttcc ctgtcttgtt 91741 tagttttgaa ggatcattcc ttcgaaacgt gttctttgaa aactagataa cagtagacat 91801 cacattcaag taatacaaga tatcacatag tgattctttt taacggttaa gttagaaagg 91861 gcgcacggtg gatgccttgg cactaggagc cgatgaagga cgggacgaac accgatatgc 91921 ttcggggagc tgtaagcaag ctttgatccg gagatttccg aatggggaaa cccaccactc 91981 gtaatggagt ggtatccata tctgaattca taggatatga gaaggcagac ccggggaact 92041 gaaacatcta agtacccgga ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc 92101 gaaacgggat tagcccaaac caagaggctt gcctcttggg gttgtaggac actctgtacg 92161 gagttacaaa ggaacgaggt agatgaagag gtctggaaag gcccgccata ggaggtaaca 92221 gccctgtagt caaaacttcg ttctctcctg agtggatcct gagtacggcg gaacacgtga 92281 aattccgtcg gaatccggga ggaccatctc ccaaggctaa atactcccta gtgaccgata 92341 gtgaaccagt accgtgaggg aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc 92401 tgaaaccgtg tgcctacaag tagtcagagc ccgttaacgg gtgatggcgt gccttttgta 92461 gaatgaaccg gcgagttacg atcccgtgca aggttaagca gaagatgcgg agccgcagcg 92521 aaagcgagtc tgaatagggc gcatgagtac gtggtcgtag acccgaaacc aggtgatcta 92581 cccatgtcca gggtgaagtt caggtaacac tgaatggagg cccgaaccca cgcacgttga 92641 aaagtgcggg gatgaggtgt gggtaggggt gaaatgccaa tcgaacctgg agatagctgg 92701 ttctctccga aatagcttta gggctagcct caaggtaaga gtcttggagg tagagcactg 92761 attggactag gggcccctac cgggttaccg aattcagtca aactccgaat gccaatgact 92821 tatccttggg agtcagactg cgagtgataa gatccgtagt cgaaagggaa acagcccaga 92881 ccgccagcta aggtcccaaa gtatacgtta agtggaaaag gatgtggagt tgcttagaca 92941 accaggatgt tggcttagaa gcagccacca tttaaagagt gcgtaatagc tcactggtcg 93001 agtgactctg cgccgaaaat gtaccggggc taaacgtatc accgaagctg cggactgttc 93061 ttcgaacagt ggtaggagag cgttctaagg gctgtgaagc cagaccggaa ggactggtgg 93121 agcgcttaga agtgagaatg ccggtatgag tagcgaaaga ggggtgagaa tcccctccac 93181 cgaatgccta aggtttcctg aggaaggctc gtccgctcag ggttagtcgg gacctaagcc 93241 gaggccgaaa ggcgtaggcg atggacaaca ggttgatatt cctgtaccac ctcctcacca 93301 tttgagcaat ggggggacgc aggaggatag ggtaagcgcg gtattggata tccgcgtcca 93361 agcagttagg ctgggaaata ggcaaatccg tttcccataa ggctgagctg tgatggcgag 93421 cgaaatatag tagcgaagtt cctgattcca cactgccaag aaaagcctct agcgaggtga 93481 gaggtgcccg taccgcaaac cgacacaggt aggcgaggag agaatcctaa ggtgatcgag 93541 agaactctcg ttaaggaact cggcaaaatg accccgtaac ttcgggagaa ggggtgctct 93601 gttagggtgc aagcccgaga gagccgcagt gaataggccc aggcgactgt ttagcaaaaa 93661 cacaggtctc tgcgaagccg taaggcgaag tataggggct gacgcctgcc cggtgctgga 93721 aggttaagag gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg 93781 ccgtaactat aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac 93841 gaaaggcgca acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg 93901 tgaagatgca ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg 93961 atattgaatg ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca 94021 gcttcggtgg aggcatcggt gggatactac cctggctgta ttgaccttct aacccgccgc 94081 ccttatcggg cggggagaca gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa 94141 aaggtaacgg aggcgcccaa aggttccctc agaatggttg gaaatcattc gcagagtgta 94201 aaggcacaag ggagcttgac tgcgagacct acaagtcgag cagggacgaa agtcgggctt 94261 agtgatccgg tggttccgca tggaagggcc atcgctcaac ggataaaagc taccccgggg 94321 ataacaggct tatctccccc aagagtccac atcgacgggg aggtttggca cctcgatgtc 94381 ggctcatcgc atcctggggc tgtagtcggt cccaagggtt gggctgttcg cccattaaag 94441 cggtacgcga gctgggttca gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg 94501 caggaaattt gagaggagct gtccttagta cgagaggacc gggatggacg caccgctggt 94561 gtaccagttg ttctgccaag ggcatcgctg ggtagctatg tgcggacggg ataagtgctg 94621 aaagcatcta agcatgaagc ccccctcaag atgagatttc ccattccgca aggaagtaag 94681 atccctgaaa gatgatcagg ttgataggtc tgaggtggaa gtgtggcgac acatggagct 94741 gacagatact aatcgatcga ggacttaacc atatttttga atgatgtcac atctgttatc 94801 tagttttgag agaacactct caatttgttt ggtggcgata gcgaagaggt cacacccgtt 94861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 94921 gtgagagtag gacgccgcca agcaattgca cgttagtgca attatggagg attagctcag 94981 ctgggagagc atctgcctta caagcagagg gtcggcggtt cgagcccgtc atcctccacc 95041 attatgccgg tgtagctcaa ttggtagagc aactgacttg taatcagtag gttgggggtt 95101 caagtcctct tgccggcacc acttttatat gatataatac tcaagtctct tgtagaagag 95161 ccattagctc agttggtaga gcatctgact tttaatcaga gggtcgaagg ttcgagtcct 95221 tcatggctca ccattttacg cgggtgtggc ggaattggca gacgcgctag acttaggatc 95281 tagtgtcttt atgacgtggg ggttcaagtc ccttcacccg cattatatag gataacagtt 95341 agaaaaactg gacatcctgt ctgcggaagt agttcagtgg tagaacacca ccttgccaag 95401 gtgggggtcg cgggttcgaa tcccgtcttc cgctccaact ataccatcca cgccggggtg 95461 gtggaattgg cagacacaca ggacttaaaa tcctgcggta ggtgactacc gtgccggttc 95521 aagtccggcc ctcggcatta tgttttgcgc ccgtagctca attggataga gcgtttgact 95581 acggatcaaa aggttagggg ttcgactcct ctcgggcgcg ccatatcttt taatagaata 95641 gataggaaat cgggaagtag ctcagcttgg tagagcacat ggtttgggac catggggtcg 95701 caggttcgaa tcctgtcttc ccgaccattt ttttatgggg ccttagctca gctgggagag 95761 cgcctgcttt gcacgcagga ggtcagcggt tcgatcccgc taggctccac caaaagtttt 95821 taaaaaagtt gttgactttg aagaagtgac gttgtatact aataaagttg ctttaacaaa 95881 gcggacaaac aaaatgatct ttgaaaacta aacaagacaa aacgtacctg ttaattcagt 95941 ttttaaaaat cgcacagcga tgtgcgtagt cagtcaaact actttatcgg agagtttgat 96001 cctggctcag gacgaacgct ggcggcgtgc ctaatacatg caagtcgagc ggacagatgg 96061 gagcttgctc cctgatgtta gcggcggacg ggtgagtaac acgtgggtaa cctgcctgta 96121 agactgggat aactccggga aaccggggct aataccggat ggttgtttga accgcatggt 96181 tcaaacataa aaggtggctt cggctaccac ttacagatgg acccgcggcg cattagctag 96241 ttggtgaggt aacggctcac caaggcaacg atgcgtagcc gacctgagag ggtgatcggc 96301 cacactggga ctgagacacg gcccagactc ctacgggagg cagcagtagg gaatcttccg 96361 caatggacga aagtctgacg gagcaacgcc gcgtgagtga tgaaggtttt cggatcgtaa 96421 agctctgttg ttagggaaga acaagtaccg ttcgaatagg gcggtacctt gacggtacct 96481 aaccagaaag ccacggctaa ctacgtgcca gcagccgcgg taatacgtag gtggcaagcg 96541 ttgtccggaa ttattgggcg taaagggctc gcaggcggtt tcttaagtct gatgtgaaag 96601 cccccggctc aaccggggag ggtcattgga aactggggaa cttgagtgca gaagaggaga 96661 gtggaattcc acgtgtagcg gtgaaatgcg tagagatgtg gaggaacacc agtggcgaag 96721 gcgactctct ggtctgtaac tgacgctgag gagcgaaagc gtggggagcg aacaggatta 96781 gataccctgg tagtccacgc cgtaaacgat gagtgctaag tgttaggggg tttccgcccc 96841 ttagtgctgc agctaacgca ttaagcactc cgcctgggga gtacggtcgc aagactgaaa 96901 ctcaaaggaa ttgacggggg cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa 96961 cgcgaagaac cttaccaggt cttgacatcc tctgacaatc ctagagatag gacgtcccct 97021 tcgggggcag agtgacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg 97081 ttaagtcccg caacgagcgc aacccttgat cttagttgcc agcattcagt tgggcactct 97141 aaggtgactg ccggtgacaa accggaggaa ggtggggatg acgtcaaatc atcatgcccc 97201 ttatgacctg ggctacacac gtgctacaat ggacagaaca aagggcagcg aaaccgcgag 97261 gttaagccaa tcccacaaat ctgttctcag ttcggatcgc agtctgcaac tcgactgcgt 97321 gaagctggaa tcgctagtaa tcgcggatca gcatgccgcg gtgaatacgt tcccgggcct 97381 tgtacacacc gcccgtcaca ccacgagagt ttgtaacacc cgaagtcggt gaggtaacct 97441 tttaggagcc agccgccgaa ggtgggacag atgattgggg tgaagtcgta acaaggtagc 97501 cgtatcggaa ggtgcggctg gatcacctcc tttctaagga tattttacgg aatataagac 97561 cttgggtctt ataaacagaa cgttccctgt cttgtttagt tttgaaggat cattccttcg 97621 aaacgtgttc tttgaaaact agataacagt agacatcaca ttcaagtaat acaagatatc 97681 acatagtgat tctttttaac ggttaagtta gaaagggcgc acggtggatg ccttggcact 97741 aggagccgat gaaggacggg acgaacaccg atatgcttcg gggagctgta agcaagcttt 97801 gatccggaga tttccgaatg gggaaaccca ccactcgtaa tggagtggta tccatatctg 97861 aattcatagg atatgagaag gcagacccgg ggaactgaaa catctaagta cccggaggaa 97921 gagaaagcaa atgcgattcc ctgagtagcg gcgagcgaaa cgggatcagc ccaaaccaag 97981 aggcttgcct cttggggttg taggacactc tgtacggagt tacaaaggaa cgaggtagat 98041 gaagaggtct ggaaaggccc gccataggag gtaacagccc tgtagtcaaa acttcgttct 98101 ctcctgagtg gatcctgagt acggcggaac acgtgaaatt ccgtcggaat ccgggaggac 98161 catctcccaa ggctaaatac tccctagtga ccgatagtga accagtaccg tgagggaaag 98221 gtgaaaagca ccccggaagg ggagtgaaag agatcctgaa accgtgtgcc tacaagtagt 98281 cagagcccgt taacgggtga tggcgtgcct tttgtagaat gaaccggcga gttacgatcc 98341 cgtgcaaggt taagcagaag atgcggagcc gcagcgaaag cgagtctgaa tagggcgcat 98401 gagtacgtgg tcgtagaccc gaaaccaggt gatctaccca tgtccagggt gaagttcagg 98461 taacactgaa tggaggcccg aacccacgca cgttgaaaag tgcggggatg aggtgtgggt 98521 aggggtgaaa tgccaatcga acctggagat agctggttct ctccgaaata gctttagggc 98581 tagcctcaag gtaagagtct tggaggtaga gcactgattg gactaggggc ccctaccggg 98641 ttaccgaatt cagtcaaact ccgaatgcca atgacttatc cttgggagtc agactgcgag 98701 tgataagatc cgtagtcgaa agggaaacag cccagaccgc cagctaaggt cccaaagtat 98761 acgttaagtg gaaaaggatg tggagttgct tagacaacca ggatgttggc ttagaagcag 98821 ccaccattta aagagtgcgt aatagctcac tggtcgagtg actctgcgcc gaaaatgtac 98881 cggggctaaa cgtatcaccg aagctgcgga ctgttcttcg aacagtggta ggagagcgtt 98941 ctaagggctg tgaagccaga ccggaaggac tggtggagcg cttagaagtg agaatgccgg 99001 tatgagtagc gaaagagggg tgagaatccc ctccaccgaa tgcctaaggt ttcctgagga 99061 aggctcgtcc gctcagggtt agtcgggacc taagccgagg ccgaaaggcg taggcgatgg 99121 acaacaggtt gatattcctg taccacctcc tcaccatttg agcaatgggg ggacgcagga 99181 ggatagggta agcgcggtat tggatatccg cgtccaagca gttaggctgg gaaataggca 99241 aatccgtttc ccataaggct gagctgtgat ggcgagcgaa atatagtagc gaagttcctg 99301 attccacact gccaagaaaa gcctctagcg aggtgagagg tgcccgtacc gcaaaccgac 99361 acaggtaggc gaggagagaa tcctaaggtg atcgagagaa ctctcgttaa ggaactcggc 99421 aaaatgaccc cgtaacttcg ggagaagggg tgctctgtta gggtgcaagc ccgagagagc 99481 cgcagtgaat aggcccaggc gactgtttag caaaaacaca ggtctctgcg aagccgtaag 99541 gcgaagtata ggggctgacg cctgcccggt gctggaaggt taagaggagc gcttagcgta 99601 agcgaaggtg cgaattgaag ccccagtaaa cggcggccgt aactataacg gtcctaaggt 99661 agcgaaattc cttgtcgggt aagttccgac ccgcacgaaa ggcgcaacga tctgggcact 99721 gtctcaacga gagactcggt gaaattatag tacctgtgaa gatgcaggtt acccgcgaca 99781 ggacggaaag accccgtgga gctttactgc agcctgatat tgaatgttgg tacagcttgt 99841 acaggatagg taggagcctt ggaaaccgga gcgccagctt tggtggaggc atcggtggga 99901 tactaccctg gctgtattga ccttctaacc cgccgccctt atcgggcggg gagacagtgt 99961 caggtgggca gtttgactgg ggcggtcgcc tcctaaaagg taacggaggc gcccaaaggt 100021 tccctcagaa tggttggaaa tcattcgcag agtgtaaagg cacaagggag cttgactgcg 100081 agacctacaa gtcgagcagg gacgaaagtc gggcttagtg atccggtggt tccgcatgga 100141 agggccatcg ctcaacggat aaaagctacc ccggggataa caggcttatc tcccccaaga 100201 gtccacatcg acggggaggt ttggcacctc gatgtcggct catcgcatcc tggggctgta 100261 gtcggtccca agggttgggc tgttcgccca ttaaagcggt acgcgagctg ggttcagaac 100321 gtcgtgagac agttcggtcc ctatccgtcg cgggcgcagg aaatttgaga ggagctgtcc 100381 ttagtacgag aggaccggga tggacgcacc gctggtgtac cagttgttct gccaagggca 100441 tcgctgggta gctatgtgcg gacgggataa gtgctgaaag catctaagca tgaagccccc 100501 ctcaagatga gatttcccat tccgcaagga agtaagatcc ctgaaagatg atcaggttga 100561 taggtctgag gtggaagtgt ggcgacacat ggagctgaca gatactaatc gatcgaggac 100621 ttaaccatat ttttgaatga tgtcacatct gttatctagt tttgagagaa cactctcaat 100681 ttgtttggtg gcgatagcga agaggtcaca cccgttccca taccgaacac ggaagttaag 100741 ctcttcagcg ccgatggtag tcgggggttt ccccctgtga gagtaggacg ccgccaagca 100801 agcttaaacc cagctcaatg agctgggttt tttgtatttt ggtttattgg tatcataaaa 100861 ttccacttaa ctgtataata taataacttt ataccgaatt ttaaatcagc aatcaggttt 100921 tgtggaccgg gaaaatggaa ataatgaagg atagagcgag aaagttgaaa attctcgaga 100981 aacggcttat agtaagatta aagtcaaata tagtcaaagt cagtaaagga gggggttgag 101041 tgggacataa tatttctgac atcattgaac aatatttaaa acgagtgtta gatcaaaatg 101101 gcaaggaaat tttagagatt aaacgaagtg aaattgcaga taaatttcaa tgcgttcctt 101161 cccaaataaa ttatgtcatc aacaccagat ttacaagcga aagaggatat attgttgaga 101221 gcaaacgcgg gggcggcggt tacatcagaa tcattaaaat taaaatgaac aatgaagttg 101281 tcctgatcaa taatataatt tctcaaatta atacccattt gtctcaagca gcctctgatg 101341 acattatttt aaggctatta gaagacaagg taatttcaga aagagaagca aaaatgatgg 101401 tcagcgtaat ggaccgctca gttttacaca ttgacttacc tgaacgtgat gaattaagag 101461 cgagaatgat gaaggcaatg ctgacttctt taaaattaaa ataagcgggt gaaaagattg 101521 atttgtcaag agtgccacga gagaccagcc acttttcact ttacaaaggt tgttaacgga 101581 gaaaaaatag aagttcatat ttgtgaacaa tgtgccaaag aaaatagtga ttcatatggt 101641 ataagtgcaa atcagggttt ctctattcat aatttacttt cgggtttact gaacatggat 101701 tcttcatttc aaaatgcagg aactcaaatg ttcagtcact cggagcaaat atctgcttgt 101761 ccgaaatgcg gaatgacttt tcagcaattc agaaaaattg gccgttttgg atgttctgaa 101821 tgttacaaaa catttcatag caacattaca ccaatcctac gtaaagtgca cagcggaaac 101881 actgtgcatg caggtaagat accgaaacga ataggcggca atcttcatgt cagacggcag 101941 attgatatgc taaaaaagga attagaatcc ttaatccatc aagaagaatt tgaaaatgca 102001 gctcatgtaa gagatcaaat tcgtttatta gaacaatcac tcaaaagtac agatagtgag 102061 gaggaacagg agtaatgtcg ctaaagcatt ttattcagga cgcactaagc agttggatga 102121 agcagaaagg acctgaaagt gacattgtac tcagcagccg catacgttta gcaagaaact 102181 ttgagcatat tcggttccct acgcggtatt ccaatgaaga agcctcatcc atcatacagc 102241 aatttgaaga tcagttttca gagcaagaaa ttcccggaat cggcaaattt gttttgatta 102301 gaatgaatga tgcacagcct ttagaaaagc gtgtacttgt tgaaaaacat ctaatcagcc 102361 cgaatttgac agagtctcct tttggcggct gtttgctttc tgaaaatgag gaagtaagcg 102421 tcatgctaaa tgaagaggac catattagaa ttcagtgtct tttccctgga tttcagcttt 102481 tagaagcaat gaaagccgca aaccaggtcg acgactggat tgaagaaaaa gttgattatg 102541 cattcaatga gcaaagagga tacttaacca gctgtcctac aaacgtaggt actggtttaa 102601 gggcttcggt catgatgcat ctgccggcgc tggttttaac taggcaaata aatcgaatta 102661 taccggcaat taatcaatta ggcttagttg ttagaggaat ttatggggaa ggcagcgaag 102721 cagtagggaa tatctttcaa atttcaaatc agatcacgct tggtaagtca gagcaggata 102781 ttgtagagga tcttaacagt gttgctgctc agttgattga acaagaacga tctgcccgag 102841 aagcgattta tcaaacttct aaaatcgaac ttgaggatcg ggtatatcgg tcatatgggg 102901 tcttgtctaa ttgccggatg atagaatcga aagaaactgc aaagtgcctt tcagatgttc 102961 ggttaggcat agacttaggc ataataaaag gactttcaag caacatactt aacgaactta 103021 tgattttgac gcagccaggg tttttacagc aatactcggg aggcgctttg cgaccgaacg 103081 aaagggacat tcgaagagcg gctctcatca gagaacggct tcacttagaa atgaatggga 103141 aaagacagga ggatgaatcg atatgatgtt tggaagattt acagaacgag ctcaaaaagt 103201 actggcgcta gcacaggaag aagcacttcg gttaggtcat aataacattg gcactgagca 103261 tattttatta ggactggtaa gagaaggaga gggcattgct gctaaagctc ttcaagcgct 103321 tggactcggt tcagaaaaaa ttcagaaaga agtagaaagt ttgatcgggc gcgggcagga 103381 aatgtctcaa acgattcatt atactcctag agctaaaaaa gtcattgagc tttcaatgga 103441 tgaggcaaga aaactcggtc attcttatgt gggaacagaa catattcttc ttggtctgat 103501 tcgtgaagga gaaggtgttg ctgcgagagt tctgaataat ctcggtgtca gcttaaataa 103561 agcaagacag caggtgctcc agcttctagg aagtaatgaa acaggatcat cagcggcagg 103621 aacaaacagc aatgcgaata cgcctacgct tgacagcttg gcaagagact taactgctat 103681 tgcgaaggaa gacagccttg accctgtaat cggcagaagc aaggagatcc agcgtgtcat 103741 tgaagtgtta agccgcagaa cgaaaaacaa ccctgttctc attggggaac caggtgtagg 103801 taaaacggct atcgcagaag gtttggcaca gcaaattatc aataatgaag tacccgaaat 103861 tttgcgtgat aaacgtgtga tgacattaga catgggaaca gttgttgccg gcacaaaata 103921 ccgcggagaa tttgaggatc gcctgaagaa ggtcatggat gaaattcgcc aggcaggaaa 103981 tatcattcta ttcatcgatg agctccatac attaatcggg gcaggcggag cagaaggtgc 104041 tattgatgca tctaatattt taaaaccttc acttgctcgt ggcgaactcc aatgtattgg 104101 tgcaacgact cttgatgagt accgtaaata tattgaaaaa gatgcagcac tggaacgccg 104161 ttttcagccg attcaggttg atcagccatc tgtagatgaa agtattcaaa ttttacaagg 104221 tctgcgtgac agatacgaag cccaccaccg cgtttctatc actgatgatg ccattgaagc 104281 tgcggttaag ctttctgaca gatatatttc tgaccgcttc cttccggata aagcaattga 104341 cttgatcgat gaagcgggtt caaaggtgag actgcgctca tttacaacgc ctcctaactt 104401 aaaagagctt gagcagaagc ttgatgaggt tcgtaaagag aaggatgcgg cagtgcaaag 104461 ccaagagttt gaaaaagctg cttccttgcg tgatactgaa caacgcctgc gcgagcaagt 104521 agaggatacg aagaaatcat ggaaagagaa gcaagggcag gaaaactcag aggttactgt 104581 ggatgatatt gcgatggttg tatccagctg gaccggtgtg cctgtatcta aaatcgccca 104641 aactgaaact gataagcttc tcaatatgga aaacattctt cactcccgtg tcatcggcca 104701 ggatgaagca gttgtagcgg ttgcaaaagc cgtcagacgt gcaagagcag gattgaaaga 104761 tcctaaacgc ccaatcggct cattcatttt cttaggccct acaggtgtag gtaaaacaga 104821 acttgcacga gcacttgctg aatccatttt tggcgatgaa gaatccatga tcagaattga 104881 tatgtctgaa tacatggaaa aacattcaac ttcaagactt gttggttcac ctccgggtta 104941 tgtgggatat gatgaaggcg gtcaattgac agagaaagtc agaagaaaac cttactctgt 105001 cgtgcttctt gatgagatcg agaaagcgca ccctgatgtc ttcaatatcc ttctgcaagt 105061 tcttgaagac ggacgattga ctgattctaa aggacgcaca gtcgatttcc gcaataccat 105121 tctgatcatg acatcaaacg tcggagcaag tgagctaaaa cgcaataaat atgtcggctt 105181 taacgttcag gatgaaactc aaaatcataa agacatgaaa gataaagtga tgggtgaatt 105241 aaaacgagcg ttcagacctg agttcatcaa ccgtattgat gaaatcattg tcttccattc 105301 acttgagaaa aaacatctca ctgagattgt gtcattaatg tctgatcaat taacgaaacg 105361 cctgaaagaa caagatcttt ctatcgaatt gacagatgct gcaaaagcga aagtcgcgga 105421 agagggcgtt gacctggaat acggtgcccg tccgttaaga agagcgatcc aaaaacatgt 105481 cgaggatcgt ttatctgaag aactcctcag aggaaatatt cataaaggac agcatattgt 105541 tcttgatgta gaagatggcg aatttgtcgt aaaaacgact gctaaaacga attaatatag 105601 aagacggaaa tgaggcatac agcatgtaag tgtatgcctc actttcatat caagaaatag 105661 aacaagggag aggtcttaca ctatatatgg ctaaaacaaa atcgaagttc atctgccaat 105721 cctgcggcta cgagtctcca aaatggatgg ggaaatgtcc gggctgtggt gcttggaata 105781 caatggtgga agaaatgatt aaaaaagcac cggccaatcg gagagcggct ttttctcatt 105841 ctgttcaaac tgtacagaaa ccttcaccta ttacatcaat cgaaacatca gaagaacccc 105901 gcgtcaaaac ccagcttggc gagtttaaca gagtactcgg cggaggtgtc gttaaaggct 105961 ccctcgtttt aattggcggt gatcctggta tcggaaagtc aacgctatta ctgcaggttt 106021 ccgctcaatt atcaggctca tcaaacagtg tcctgtatat ttcgggagaa gaatctgtaa 106081 agcaaacgaa gctgcgagca gaccgtctcg gcattaataa tccgtcactg catgttttat 106141 ctgaaaccga tatggagtat atttcgtctg ctatacaaga gatgaatcca tcgtttgtcg 106201 ttgttgactc tattcaaacg gtttaccaaa gcgatattac atctgctcca ggcagtgtgt 106261 cacaggtcag agaatgtacc gctgagctga tgaaaattgc aaaaacaaaa ggtattccga 106321 tttttatcgt agggcacgtg acgaaagaag ggtctattgc aggtccgaga ctgttggagc 106381 atatggttga cactgtttta tattttgaag gagaacgcca ccatactttc cgtattttgc 106441 gggctgtaaa aaaccgtttc ggatctacaa acgaaatggg cattttcgaa atgcgggaag 106501 aggggctcac tgaggttttg aatccttcgg aaattttctt agaagaacgc tctgctggtt 106561 ccgcaggctc gagtatcact gcctctatgg agggcactag accgattctc gttgaaattc 106621 aggcactcat ctcgccaaca agttttggca acccaaggcg tatggcaacg ggaatagacc 106681 ataacagggt ttctctgtta atggctgtgt tagaaaaaag agttggactg ctgctgcaaa 106741 atcaggatgc ttatttgaaa gtggctggcg gcgttaagct tgatgaaccg gcaattgatc 106801 ttgcgattgt gattagtatt gcatcaagct ttagagacac acctccaaat cctgcagatt 106861 gttttattgg agaagtggga ttaaccggag aagtccggcg ggtttcaaga attgaacagc 106921 gtgtgaaaga agcggcaaag cttggtttta aacgcatgat catacccgcg gcaaatctgg 106981 atggatggac aaaaccaaaa gggattgagg ttatcggagt agcaaatgtt gcagaagcgc 107041 ttcgtacttc attaggagga taatagatgg aaaaagagaa aaaaggggcg aaacacgagt 107101 tagacctgtc atctatattg cagtttgttg ctccgggtac accgctcaga gcggggatgg 107161 aaaacgtctt gagagcaaat acaggcggtc tgattgttgt tggatataat gataaagtaa 107221 aagaagtggt ggacggcggc tttcacataa acacggcttt ttctccggcg catttatatg 107281 agctggctaa aatggatgga gcgatcattt taagtgattc tggtcaaaag atcctatacg 107341 cgaatactca gctgatgccg gatgccacaa tttcttcatc agaaacagga atgcggcaca 107401 gaactgccga aagagtagct aagcaaactg gctgtcttgt aatcgccatt tctgaaagaa 107461 gaaatgtcat aacgttatat caggaaaaca tgaagtatac actaaaagac ataggattta 107521 ttttaaccaa ggcgaaccaa gccattcaaa cacttgaaaa atataagaca atcctcgata 107581 aaacgattaa tgcactgaac gcgttagagt ttgaggaact tgttaccttc agtgatgtct 107641 tgtctgtcat gcatcgttat gaaatggtac tgagaatcaa aaacgaaatt aatatgtata 107701 tcaaagagct ggggacagaa gggcatctga tcaaactgca agtcattgaa ttgattacgg 107761 atatggaaga agaggccgct ttatttatta aggactatgt aaaagaaaag attaaagatc 107821 cgtttgttct cttgaaggag ctgcaggata tgtccagtta tgatctgctg gatgattcca 107881 ttgtgtataa gcttctcggt taccctgctt ctactaatct tgatgattat gtattgccga 107941 gaggatacag gctgttaaat aagataccgc gtcttccgat gccgattgtt gaaaatgttg 108001 tagaagcatt tggagtcctg ccaaggatta ttgaggcgag tgcagaagaa ttagatgaag 108061 tagagggaat cggtgaagta cgagcccaaa aaatcaaaaa aggattaaaa cgcctgcaag 108121 agaagcatta tttagacaga caactgtgat ttcggttaaa accttatgaa tacgggtata 108181 ttaatgttgg tttttgttta ttctgatatt cgtaggatgc ataagacttt gtgaaattaa 108241 aatgttaaaa aaggaggtgg gggtatgtta aaacgaatag ttcaggcgtt cttcattatt 108301 tttggcggcg ttgttggtat atttttgata cctgaattgt ttgtactgtt aaatatacag 108361 gacatacctt taataacaaa cgcatatacg tctgcggcaa taggagcaat tatctttttt 108421 ctcatcagta tatggggtac agaatacgtt gtgaactggg tgaagtggat agaggattca 108481 ttgttaaaag cgccggttcc agatttgtta tttggaagtc ttggcttagt ttttggactt 108541 ataattgctt atcttatcgt aaatgttatt cctttagaca atatacctta ccgcatattc 108601 agcacaataa ttcctgtatt tttggctttc ttcctcggtt atctcggctt ccaggtgggc 108661 tttaagaaaa aggatgaatt gatcagcctg ttttccattt ccgccagaat gcaaaagaaa 108721 aaaggaacag ctgatgaaga acatgaggtt caagacaaga agctgaaaat tttggacact 108781 agtgttatta ttgatgggag aatagcagat atttgtcaga ctggtttttt agagggagtt 108841 atcgtgattc cgcagtttgt ccttgaggaa ttgcagcata ttgcagactc ttcagatgtt 108901 ttaaaacgaa acagaggacg ccgcggtctt gatatcctga accgcattca gaaagaatta 108961 gacattgaag ttgaaattta cgaaggcgac tttgaagata ttcaggaggt tgacagcaag 109021 ctcgtcaaac ttgctaagct gacatccggg gtcgttgtga cgaatgattt taatttaaat 109081 aaagtgtgcg agcttcagaa ggtagcagta ttaaacatta atgaccttgc caatgcggtt 109141 aagcctgttg tgcttcctgg cgaggaaatg aatgttcagg tcattaagga cgggaaagag 109201 cataatcagg gagttgccta cttggatgac ggtacgatga ttgtcgttga agaaggacgg 109261 aattatatcg gcaagcatat tgatgtactc gtcacaagtg tgctgcagac agcagcggga 109321 cgaatgattt ttgcgaagcc taagctgttg gagaaggcgc tgtaaaggga gaagaaacaa 109381 tgagttatga tgtggtgatt cctgcagccg gacagggaaa gcggatgaag gcagggagaa 109441 ataaactgtt cattgagctg aagggagacc cggtgatcat acacacgtta agagtgtttg 109501 acagccaccg gcagtgcgat aaaatcattt tggtgattaa cgagcaggag cgggagcact 109561 ttcagcaatt gctgtccgat tacccgtttc aaacttcaat tgagcttgtt gcaggcggag 109621 atgagcgaca gcacagtgtg tataaggggc tgaaagccgt aaagcaggaa aagattgtcc 109681 ttgtacatga cggtgcccgt ccatttataa aacatgaaca aattgacgaa ctgatcgcag 109741 aggcggaaca gacaggagcg gccatccttg ctgttccggt aaaagatacg attaaacgcg 109801 ttcaagattt acaagtcagt gagacgattg aacgttcaag cttgtgggct gtccaaacgc 109861 cacaagcttt tcgtctttct ttattgatga aggctcacgc tgaggccgag cgcaagggat 109921 ttttagggac ggatgacgcc agcctcgttg aacagatgga gggcggttcg gtccgtgttg 109981 tagaaggcag ctatacaaat attaagctga cgacgccaga cgatttgacg tcagctgaag 110041 ctatcatgga atcagaaagt gggaataaac atgtttagaa ttggacaagg atttgatgtg 110101 catcaattag tggagggccg tcctctcatt attggcggaa ttgaaatccc gtacgaaaaa 110161 gggctgcttg gccattctga tgcagacgta ttgttgcata ccgtcgctga cgcctgcctg 110221 ggagctgtgg gtgaaggaga cataggcaag cattttcctg acacagatcc cgagttcaag 110281 gacgcagatt ctttcaaatt acttcagcat gtctggggaa tcgtgaaaca gaaggggtat 110341 gtccttggga acattgattg caccatcata gcgcaaaagc cgaagatgct gccgtacata 110401 gaagatatga gaaaaagaat tgctgaaggc cttgaggcag atgtttctca agtaaatgta 110461 aaagcaacaa cgacagaaaa gcttggattt acaggccggg cggaaggaat agcggctcag 110521 gcgacagtac tgatacaaaa aggctaactt gttttgatgc cgggtctatt tggtggtaga 110581 atagattcat acatttttgc ctgaggccat acatgacatg aaaggaagta tttgaaaatg 110641 ggaaacgaag tacgcgtccg ttatgcaccg agtccaaccg gacatttgca tattggaaat 110701 gccagaacgg cgctttttaa ttatttattt gcccgcaatc aaggcggtaa gtttatcatt 110761 cgagttgagg atactgataa aaagcgcaat attgagggcg gagaacaaag ccagctgaat 110821 tatctgaagt ggctaggtat tgactgggat gagagtgtgg atgtcggagg agagtacggt 110881 ccataccgtc agtcagagcg taacgatatc tataaagtgt actatgaaga gcttcttgaa 110941 aaagggcttg cttataaatg ttactgtacg gaagaagagc ttgaaaaaga gcgtgaagaa 111001 cagattgccc gcggagaaat gcctcgttat tccggaaaac acagagacct gactcaggaa 111061 gaacaggaga aatttatcgc cgaaggcaga aaaccaagta ttcgtttccg tgtgccggaa 111121 ggaaaagtca tcgccttcaa cgacatcgta aaaggcgaaa tttcttttga atcagatggc 111181 atcggcgact tcgttattgt gaaaaaggac ggaacgccta cttataactt cgcggtagct 111241 attgatgact acttaatgaa aatgacacac gtgctgcgcg gtgaggatca tatttctaac 111301 acaccgaaac agattatgat ctatcaagca ttcgggtggg atattcctca gttcggacac 111361 atgacgctga ttgtaaacga aagccgtaaa aagctcagca aacgtgatga atccattatt 111421 caattcatcg agcagtacaa agagcttggc tacctgccag aagcgctgtt caactttatc 111481 ggcttgttag gctggtcacc ggttggagaa gaagagcttt tcacaaaaga gcagtttatt 111541 gaaatttttg atgtaaatcg tttatctaaa tcaccagctt tgtttgatat gcataagcta 111601 aaatgggtta acaaccaata tgtgaagaag ctggatcttg atcaggttgt tgaactgacg 111661 cttccgcatt tgcaaaaagc cggcaaagtt ggcactgagc tttctgctga agaacaagaa 111721 tgggttcgta aactgatttc cctgtatcat gagcaattaa gctacggtgc ggaaattgtt 111781 gagctgactg atttgttctt tacggatgag atcgagtata atcaagaagc gaaagctgtt 111841 ctggaagaag aacaggttcc tgaagtgctc agcacattcg cagcgaagct tgaagagctt 111901 gaggagttca ctccggataa tatcaaagca tcgatcaaag cagtgcagaa agaaactggc 111961 cataaaggga aaaaactgtt tatgccgatt cgtgttgctg taacagggca aactcacggt 112021 ccggaactgc cgcaatcaat tgaattgatc ggtaaagaga ctgcaattca gcgtttaaag 112081 aatatctaaa taaatgattg ttgacaggga agagtataaa gctttaggcc attacagaaa 112141 ggatcttcat tggctgagag agatccatga gccgggtttt agaagtgcgc ccttaagacc 112201 tttgaagaac gttttttgaa atcagtattc aaaggcggcc gccgccgtta caggctgaag 112261 ttgggagagc agaagtctgc ttttcaaaca gagtggaacc gcgcggttaa agcgtctctg 112321 tcatgtttac atgcagagac gcttttttta ttgggtagag gaaatcagat agagaaacgg 112381 ggggaagcat gtgtttttta gaatgctcaa agaagacatt gatactgtgt tcgatcaaga 112441 tcccgcagca agaagctatt ttgaagtgat tttaacttat tccggtttac atgctatatg 112501 ggcgcatcgg attgcacatg ctttatataa acgaaaattt tatttccttg cacgccttat 112561 atctcaagta agccgatttt ttaccgggat agaaatccac cccggcgcta caatcgggag 112621 aagatttttc atagaccacg gcatgggggt tgtcattggg gagacatgtg aaatcggcaa 112681 taacgtaacc gtttttcagg gggttaccct cgggggaacg ggaaaagaaa agggaaaaag 112741 gcacccaacg attaaagatg acgcattgat agccacaggt gctaaagtgc tcggttctat 112801 tacggtcggt gaaggctcaa agattggcgc tggttcagta gtgctgcatg atgttcctga 112861 tttttcaaca gttgtcggta tccctggacg ggtcgttgta caaaatggca agaaagtaag 112921 acgcgattta aaccatcagg atttgcccga tccagttgct gaccgcttta agtctttgga 112981 acagcagatt ttagagctga aggcagaact tgaagacaga aaagaaagga tcaatcaaaa 113041 atgacaatca cactttataa tacattgact agacagaagg aaacattcgt tcctcttgaa 113101 gagggaaaag tgaaaatgta tgtatgcgga cccacggttt acaattacat tcatatcggg 113161 aacgcgcgtc cggcaatcgt ttacgatacg gttcgaaact atttagagta taaaggctat 113221 gatgtgcagt atgtctctaa cttcacagac gtagacgata aattaattaa agcggcaaat 113281 gaactcggtg aggatgtacc caccatttca gagcgtttta ttaaagcata ctttgaagac 113341 gtaggtgcgc tcggctgccg aaaagccgac cttcatccgc gagtaatgga gaacatggat 113401 gccattatcg aattcgtaga tcagctcgtg aaaaagggct acgcatatga atcagaaggt 113461 gacgtatatt tcaaaaccag agcatttgaa gggtacggaa agctttctca gcaatcaatc 113521 gatgaactaa gatcaggtgc acgcatccgg gtcggcgaga aaaaagaaga tgctcttgat 113581 ttcgcactgt ggaaagcggc aaaagaagga gaaatctctt gggatagccc ttgggggaaa 113641 gggcgtccgg gctggcacat tgaatgctca gcaatggtga aaaagtatct cggtgaccag 113701 attgatatcc atgcgggcgg acaggattta acattccctc accatgaaaa cgaaattgcg 113761 caatctgagg cgctgacagg caaaacgttt gcgaagtact ggcttcataa tggttatatc 113821 aatattgata atgaaaaaat gtcaaaatca ctaggcaact ttgtgcttgt gcatgacatc 113881 attaaacagc atgatccgca gcttttgaga ttctttatgc tatctgttca ttatcgccat 113941 ccgattaact attcagaaga gcttctggag aatacgaaaa gcgcgttcag ccgtttaaaa 114001 acagcgtaca gcaatcttca gcaccgtctg aacagcagta cgaatttaac cgaagatgac 114061 gatcaatggc ttgaaaaggt tgaagaacac cgcaaagcat tcgaagaaga gatggacgat 114121 gattttaata cggcgaatgc catttcagtc ttgtttgact tagcgaaaca cgccaattat 114181 tatcttcaga aagatcatac ggctgatcat gtgattacgg cgtttattga gatgtttgac 114241 cgcattgttt ctgtcctcgg tttttcgttg ggtgagcagg aacttctcga tcaagagatt 114301 gaagacttaa tcgaaaagcg aaatgaagcg cgccggaatc gcgattttgc attgtcagac 114361 cagatccgcg accagctgaa aagcatgaat atcattcttg aagatacggc tcaaggcact 114421 cgctggaaac ggggagaata acagatgctt gaatttgata cgataaaaga ttctaagcag 114481 cttaacggtc ttgcgcttgc ttatataggt gatgccattt ttgaagtgta tgtcaggcat 114541 cacctgctta agcagggctt taccaaacca aatgatcttc ataagaaatc aagccggatt 114601 gtttcagcaa agtcacaggc tgagatccta ttttttctgc agaatcaatc attttttacg 114661 gaagaagagg aagcggtgct gaaaagaggc agaaatgcca agtcagggac aacacctaaa 114721 aatacagatg ttcagacgta ccgctacagt acagcatttg aagcgcttct gggctacctt 114781 tttctagaga aaaaagagga acgacttagt cagctcgtag ccgaagctat acaattcggg 114841 acgtcaggga ggaaaacaaa tgagtcagca acatgattac gtcataggga aaaatgcagt 114901 gatcgagacg ttaaaatctg atcggaagct gtataagctg tggatggcgg aaaacaccgt 114961 aaagggacaa gcacagcaag tgattgagct tgccaaaaag cagggaatca cgattcaata 115021 cgtcccgaga aaaaaactcg atcaaatggt gacaggacag catcagggcg tagtggcaca 115081 ggttgcagcg tatgaatatg cagaactgga cgatttatat aaagcagccg aagaaaaaaa 115141 tgaacagcct ttcttcctca ttctggacga gcttgaagac cctcataatc ttggttccat 115201 tatgaggaca gcagatgcgg tcggcgctca tggcatcgtc attccaaaac ggagagctgt 115261 cgggctgaca acaacagtgg caaaagcttc aacaggagca attgagcaca ttcctgtagc 115321 aagagtcacc aatttggcac ggacgttaga agagatgaaa gagcggggaa tctgggttgt 115381 cggaacggat gcgtccgcgc gtgaggattt ccgtaatatg gacggcaata tgcctttggc 115441 tctagtcatc ggaagtgaag gaaaagggat gggccgcctt gtgaaggaaa agtgcgattt 115501 tctcattaaa ctcccgatgg ccggaaaggt aacttcacta aatgcatctg tcgcggctgg 115561 tcttttgatg tatgaagtct accggaaacg aaaccctgtg ggagaataaa gacccatgga 115621 tatcctgtta gtagacgggt acaacatgat tggagcctgg ccgcagctga aggatttaaa 115681 agcgaacagt tttgaagagg cgagagacgt actgattcag aaaatggcgg aatatcaatc 115741 gtatacagga aacagggtta ttgttgtttt tgacgcgcat ctcgtaaaag ggcttgagaa 115801 aaaacagacc aaccatagag ttgaagtaat ttttacaaaa gaaaatgaga cggctgatga 115861 gcggatagaa aagctcgctc aggctttgaa taatattgcg actcaaattc acgttgcgac 115921 ctctgactat actgagcagt gggcgatttt cggacagggg gcattgcgga aatcggcccg 115981 ggagcttctg agagaggtag aaacgattga aaggcgaata gagagacggg taagaaaaat 116041 cacttccgaa aagccggcgg gtaaaattgc tttatcggaa gaggttttga aaacgtttga 116101 aaagtggagg cggggagact tagattaagt tgacgctttt ttgcccaata ctgtataata 116161 tttctatcta cgtgcgccgg ggggatcgga gtgaatctac agaacaacaa gggaaaattc 116221 aacaaagagc agttttgcca gttggaggac gagcaggtca ttgaaaaggt tcatgttggg 116281 gacagtgatg cgttagatta cttgattacg aagtaccgaa actttgttcg ggcaaaagca 116341 agatcctatt tcttaatagg ggcggacaga gaggatattg ttcaggaagg catgataggc 116401 ctctataagt ctattcgtga cttcaaagag gacaagctta cctcattcaa agcttttgca 116461 gaattatgta ttacccgcca aattattacc gcaataaaga cagctactcg ccagaaacac 116521 attcctttga attcctacgc ctcattagat aaaccgatct ttgatgaaga atcagaccga 116581 acgctgctgg atgtcatttc aggagcgaaa accttaaatc ctgaggaaat gatcattaat 116641 caggaagaat ttgatgatat tgaaatgaaa atgggagaac tattaagtga tttagagaga 116701 aaagtactcg tcttatatct cgacgggaga agttaccaag agatttctga tgaactgaac 116761 cgacatgtga aatcgatcga caatgccctt cagcgtgtga aacgcaagct ggagaagtac 116821 ttggaaattc gcgaaatcag tttgtaatag gaatttatgc tatattgaca gtatttttct 116881 gactatgata tgttactaaa gataagaact aatgtctatt tagaaaaagg tgtaatgaca 116941 tgagaaaaaa gattacgtta gcatgcaaga catgcggaaa ccgtaattat acgacaatga 117001 agagctctgc atcagcggct gagcgattag aagtaaagaa atactgcagt acttgcaatt 117061 cacatacagc tcatcttgaa acaaaatagt ttttgcgctt ttaaattgtg gaggtctttt 117121 acatgcgtat tatgaaattc tttaaagatg ttgggaaaga aatgaaaaag gtaagctggc 117181 ctaaaggaaa agagttaacg cgttatacca ttacggtaat ttcaacagtt atcttttttg 117241 ttatcttttt tgccctcctt gacacaggaa tttctcaatt aattcgttta atagttgaat 117301 aatgatcagc aatacgtgct ataatagatc ataatattac ttgccaaaac ccgttcagcg 117361 ggttttttat tgtggcttaa aatgaaagtt atcataggct tgccgcctat tttttgaagc 117421 gttatggtaa ttcactaaaa ccaaatgcgg ggagggaagg actggacagt cctgaataga 117481 atggaaaaga attggtatgt tgttcacacg tactctggtt atgagaataa agtaaaagcc 117541 aacttggaaa agcgtgttga atcaatgggg atgcaggata aaattttccg tgtagtcgta 117601 cccgaagaag aagaaacgga tatcaaaaac ggcaagaaaa aagtcgtgaa aaagaaagta 117661 ttccctggtt atgtgcttgt tgaaattgta atgacagacg actcttggta tgtcgtccgc 117721 aacacgccgg gcgttactgg attcgtagga tctgccgggt caggttcaaa accgacgccg 117781 cttcttccgg gggaagcaga aaccattctg aagagaatgg gcatggatga acgaaaaact 117841 gatattgact ttgaactgaa agagacagtg aaagtaatag acggaccttt tgctaacttt 117901 acaggatcaa ttgaagagat tgattatgat aaaagcaagg tcaaagtttt cgttaatatg 117961 tttggccgtg aaacgccggt tgagctggaa tttacccaaa tcgataaatt gtaatgtgaa 118021 aaaacttgaa attgctatat ataaatgata atatagcaaa ggtacgtctt ggacttatcc 118081 aaggcaacta gcatgatatt tcgtcattca tataaagaat gaaaccttga gtgggagggt 118141 ttaccctatt accacatcac ggacttaagg aggtgtgtct cgtggctaaa aaagtagtta 118201 aagttgtaaa attgcaaatt cctgctggaa aagctaaccc agcaccacca gttggacctg 118261 cacttggtca agccggtgtt aacatcatgg gattctgtaa ggagtttaac gctcgtacag 118321 ctgaccaagc tggtttaatc attcctgttg aaatttcggt ttacgaagac cgttcattta 118381 catttattac aaaaactcca cctgctgcag tattgcttaa aaaagcagct ggaattgagt 118441 ctggttctgg tgaaccaaac cgtaataaag tggcaaccgt taagcgcgat aaagtacgcg 118501 aaatcgctga aacgaaaatg cctgacttaa acgcagcaga cgttgaagcg gcaatgcgca 118561 tggttgaagg tactgcccgc agtatgggta ttgtaatcga ggattaattt gtttcttgtc 118621 gggttgcgag ttttaacaag ttcgcaaccc ttattcgtgg gaggttattc cgctataacc 118681 acataaggag gaaattttaa aatggctaaa aaaggtaaaa agtacgttga agctgctaag 118741 cttgtagacc gttctaaagc ttacgacgtc tctgaagcag tagctctcgt taaaaaaaca 118801 aacacagcta aattcgacgc tacagttgaa gtggctttcc gtttaggggt tgaccctcgt 118861 aaaaacgacc agcaaatccg tggagcagtt gtgcttccaa acggaactgg taaaactcag 118921 cgcgttctcg ttttcgcaaa aggcgaaaaa gcgaaagaag ctgaagctgc tggtgcagat 118981 ttcgtaggcg atactgacta catcaacaaa attcaacaag gctggttcga tttcgatgtt 119041 atcgtagcta cacctgacat gatgggtgaa gttggtaaaa tcggtcgtgt acttggacca 119101 aaaggtttaa tgccgaaccc taaaactggt acagttactt tcgaagttga aaaagctatc 119161 ggcgaaatca aagctggtaa agttgaatac cgcgttgata aagctggaaa cattcatgtt 119221 cctatcggta aagtttcttt cgaggatgaa aaacttgttg agaacttcac aacaatgtac 119281 gatacaatcc ttaaagctaa acctgctgca gctaaaggcg tttacgtgaa aaacgttgct 119341 gtaacttcta ctatgggacc tggtgtcaaa gtagactctt caacttttaa cgtaaaataa 119401 tattgacatg acatcaacat tctgatatta ttcaaaatgt tgtaaaatag aatatcattt 119461 ataccgtaga cagtaggggc ctaaccgctt aattatccta ccgaggtgta tattatcaca 119521 gctattacgt tacgtatgct tgtatataca gcctccatgt ctcatggagg ctttttatat 119581 ggaatccgtc gtctcagtcg tgatcaccta acggtataag tgttacacaa gaatctacag 119641 gaggtgtaac catgagcagc gcaattgaaa caaaaaaagt tgttgttgaa gaaattgctt 119701 ctaaactgaa agaaagtaaa tcaacgatca tcgttgacta tcgcggactt aacgtttctg 119761 aagtaactga acttcgtaaa cagcttcgcg aagctaacgt tgagttcaaa gtttacaaaa 119821 atacgatgac tcgccgtgcg gttgaacaag ctgagcttaa tggtttgaat gatttcttaa 119881 ctggaccgaa cgcgatcgca ttcagcactg aagatgttgt cgctccggct aaagttctta 119941 atgacttcgc taaaaatcac gaagctcttg aaatcaaagc tggcgttatc gaaggtaaag 120001 tttctactgt tgaagaagtg aaagctcttg ctgaacttcc atcacgcgaa ggcttgcttt 120061 ctatgttgct tagcgtactt caagctccag ttcgcaacct tgctcttgct gcaaaagctg 120121 tggcagaaca aaaggaagaa caaggcgctt aatctaatca gtttttcata aattaaaaca 120181 aaatggagga attacaaatg gctttaaata tcgaagaaat cattgcttcc gttaaagaag 120241 caactgtact tgaattgaac gacctagtaa aagcaatcga agaagaattt ggcgtaactg 120301 ctgctgctcc tgtagctgta gctggcggag ctgctgctgg cggagctgct gaagagcaaa 120361 gcgaattcga tcttatcctt gctggtgcag gatctcaaaa aatcaaagtt atcaaagttg 120421 tacgtgaaat cactggtctt ggcttgaaag aagctaaaga gcttgttgac aacactccaa 120481 aaccacttaa agaaggtatt gctaaagaag aagctgaaga gcttaaagct aaacttgaag 120541 aagttggcgc ttctgtagaa gttaagtaat cttcacttac ctgtagggga agctcgcttt 120601 tatgaggcga gctttttctt tgccattctt taagccatga aaaaaggagg ttctaataat 120661 gagtgagcac tattattcag aaaaaccttc agtaaaaagc aacaagcaaa cctggtcttt 120721 taggcttcgg aataaagatt tcacgtttac cagcgacagc ggggtttttt ctaaaaaaga 120781 agttgatttc ggctcccgcc tgctgattga ttcttttgaa gagcctgagg ttgagggcgg 120841 cattttagat gtaggctgcg gatacggccc gattggttta tcgctcgcca gcgactttaa 120901 agaccggacc atccacatga ttgacgttaa tgagagagcc gtagaactat caaatgaaaa 120961 tgcggaacag aacggaataa caaacgttaa gatttatcaa agcgatttgt tttcaaacgt 121021 tgattctgct caaacatttg cttctattct tacaaatccc ccaatccgag ccggaaaaaa 121081 agttgtccat gctatctttg agaaaagcgc tgaacactta aaagcttcag gtgaattgtg 121141 gatcgtcata cagaaaaagc aaggcgcgcc ttctgccatt gaaaagctcg aggaactgtt 121201 cgatgaagtt tccgtcgttc aaaaaaagaa aggctattat atcataaaag caaaaaaagt 121261 ttgactcggt attttaacta tgttaatatt gtaaaatgcc aatgtatata ttttgcttga 121321 tatgatgaat tgtcaatatc tatgtataaa ttatacaagt atggaaatgc taataaaatc 121381 ggtatttgtt tttggatgtg gttttcttaa ttagaaaccc ttttttcttt tgtcttgtaa 121441 aagtattttc tttctttgga agaaatgctt attacacata taatacgcat gatttgaggg 121501 gtgaatcagt tgacaggtca actagttcag tatggacgac accgccagcg cagaagctat 121561 gctcgcatta gcgaagtgtt agaattacca aatctcattg aaattcaaac ctcttcttat 121621 cagtggtttc ttgatgaggg tcttagagag atgtttcaag acatatcacc aattgaggat 121681 ttcactggta acctctctct tgagttcatt gattatagtt taggtgagcc taaatatcct 121741 gtagaggaat caaaagaacg tgatgtgact tactcagctc cgctaagagt gaaggttcgt 121801 ttaattaaca aagaaactgg agaggtaaaa gaccaagatg tcttcatggg tgatttccct 121861 attatgacag atacaggtac ttttatcatt aacggtgcgg aacgtgttat cgtttcccag 121921 cttgttcggt ctccaagtgt atatttcagt ggtaaagtag acaaaaacgg taaaaaaggt 121981 tttaccgcaa ctgtcattcc aaaccgtggc gcatggttag aatacgaaac tgatgcgaaa 122041 gatgttgttt atgtccgcat tgatcgcaca cgtaagttgc cggttacggt tcttttgcgt 122101 gctctcggct tcggctccga tcaagagatt cttgatctca taggagaaaa cgaatacctg 122161 cgaaatacgc ttgataaaga taacacagaa aacagcgaca aagcgttgct ggaaatttac 122221 gagcgtctcc gtcctggaga gccgcctaca gtagaaaatg cgaaaagctt gcttgattct 122281 cgtttctttg atccgaaacg atacgatctt gccaatgtag gacgctataa aattaataaa 122341 aaacttcata ttaagaatcg cctcttcaat cagagacttg ctgaaacgct tgttgatcct 122401 gaaacaggag aaatccttgc tgaaaaaggc cagattcttg atagaagaac gcttgataaa 122461 gtactgccat acttagaaaa cggaatcggt tttagaaagc tgtatccgaa tggcggcgtt 122521 gttgaagatg aagtgactct tcaatcaatt aaaatctttg ctccgactga tcaagaagga 122581 gaacaggtta tcaatgtaat cggcaatgct tacatcgaag aagagattaa aaacatcacg 122641 cctgctgata ttatttcttc aatcagctac ttcttcaacc tgctgcacgg agtaggcgac 122701 acagatgata tcgatcatct tggaaaccgc cgtttacgtt ctgtaggcga gcttctccag 122761 aaccaattcc gtatcggttt aagccgtatg gagcgtgtgg ttcgtgagag aatgtcaatt 122821 caagatacga atacaattac gcctcagcag ctgatcaata ttcgtcctgt tattgcgtcc 122881 attaaagagt tctttggaag ctcacagctt tctcaattca tggatcagac gaacccgctt 122941 gctgaattaa cgcacaagcg tcgtctgtca gcattaggac cgggcggatt gacacgtgag 123001 cgtgccggaa tggaagtgcg tgacgttcac tactcccact atggccgtat gtgtccgatt 123061 gaaacgcctg agggcccgaa catcggtttg atcaactcac tatcatctta tgcaaaagta 123121 aaccgttttg gctttattga aacgccatat cgccgcgttg accctgaaac agggaaggta 123181 acgggcagaa tcgattactt aactgctgat gaagaggata actatgttgt cgctcaagcg 123241 aatgctcgtc ttgatgacga aggcgccttt attgatgaca gcatcgtagc tcgtttccgc 123301 ggggagaaca ccgttgtttc cagaaatcgt gtagactaca tggatgtatc gcctaagcag 123361 gttgtatctg ctgcgacagc atgtatcccg ttcttagaaa acgatgactc caaccgtgcc 123421 ctcatgggag cgaacatgca gcgtcaggct gtgcctttga tgcagccgga agcgccattt 123481 gttggaactg gtatggaata cgtatcagga aaagactctg gtgccgctgt tatttgtaaa 123541 caccctggta tcgttgaacg cgtagaagcc aaaaacgttt gggttcgccg ttatgaagaa 123601 gtagacggtc aaaaagtaaa aggaaacctg gataaataca gcctgctgaa atttgtccgc 123661 tctaaccaag gtacgtgcta caaccagcgt ccgatcgtaa gtgtcggcga tgaagtggta 123721 aaaggagaaa tccttgctga cggtccttct atggagcttg gtgaacttgc acttggccgt 123781 aacgtaatgg tcggcttcat gacgtgggat ggctacaact atgaggatgc catcatcatg 123841 agtgaacgcc tagtgaagga tgatgtttat acatctatcc acattgaaga atacgaatca 123901 gaagcacgtg atacgaaact tggacctgaa gaaatcactc gcgatattcc aaacgtcggt 123961 gaagatgcgc ttcgcaatct tgatgaccgc ggaatcatcc gtattggggc agaagtaaaa 124021 gacggagatc ttcttgttgg taaagtaacg cctaaaggcg taactgaact gactgccgaa 124081 gaacgccttc ttcacgccat ctttggcgag aaagcccgcg aggttcgtga tacttctctt 124141 cgtgtgcctc atggcggcgg cggaattatc catgacgtta aagtcttcaa ccgtgaagac 124201 ggagacgaac ttcctccagg tgttaaccag ttagtacgcg tatatatcgt tcagaaacgt 124261 aagatttctg aaggggataa aatggccggt cgtcacggta acaaaggtgt tatctctaag 124321 attcttcctg aagaggatat gccttacctt cctgacggca caccaattga tatcatgctt 124381 aacccgctgg gcgtaccatc acgtatgaac atcgggcagg tattggaact tcacatgggt 124441 atggccgctc gttaccttgg cattcacatt gcatctcctg tatttgacgg agcgcgagaa 124501 gaggatgtct gggaaacact tgaagaagcc ggcatgtctc gtgacgccaa aacagtgctt 124561 tacgacggac gtactggaga gccgtttgat aaccgtgtat ctgtcggtat catgtacatg 124621 atcaaactgg ctcacatggt tgacgataaa cttcatgcac gctctacagg cccttactca 124681 cttgttacgc agcagcctct tggcggtaaa gcgcaatttg gcggacagcg ttttggtgag 124741 atggaggttt gggcacttga agcttacggt gcggcttaca ctcttcaaga aattctgact 124801 gttaagtctg atgacgtggt tggacgtgtg aaaacatacg aagccatcgt taaaggcgac 124861 aatgttcctg aaccaggtgt tccggaatca ttcaaagtat taatcaaaga acttcaaagc 124921 ttaggtatgg atgtcaaaat cctttctggt gatgaagaag aaatagaaat gagagattta 124981 gaagacgaag aagatgcgaa acaagctgac ggcctggcat tatcaggtga tgaagagccg 125041 gaagaaacag catctgcaga cgttgaacgc gatgtagtaa caaaagaata atctctagtt 125101 ataaaggcaa gtgacatcgg ttaatccgaa gataaaaagg gaggtaggcc ccttgctaga 125161 tgtgaacaat tttgagtata tgaacatcgg tcttgcttca ccagataaaa tccgttcatg 125221 gtcttttggt gaagtgaaaa agcctgaaac gataaactat cgtacgttaa aacctgaaaa 125281 ggacggtcta ttctgcgaac gcattttcgg accgactaag gactgggaat gtcattgcgg 125341 gaagtacaag cgagttcgtt ataaaggcgt agtttgtgac cgctgcggag tcgaagtaac 125401 acgggctaaa gtccgtcgtg agagaatggg gcacattgaa ctggctgccc cagtttccca 125461 catttggtat ttcaaaggta ttccaagccg tatgggtctt gtgctggata tgtcacctcg 125521 tgctttagaa gaagtcattt actttgcttc ttacgttgta actgatccgg cgaatacacc 125581 gcttgaaaag aaacagcttc tgtctgagaa agaataccgt gcttatcttg ataaatacgg 125641 taataaattc caagcatcta tgggtgctga agcaattcat aaacttcttc aagatatcga 125701 tcttgtaaaa gaagttgata tgttaaaaga agagctgaaa acttcacaag gacaacgccg 125761 tactcgtgcg atcaaacgtc ttgaagtttt agaagccttc cgtaactcag gaaacaagcc 125821 ttcttggatg atccttgatg tgcttcctgt tattcctccg gagcttagac cgatggttca 125881 gctagatggc ggacgttttg cgacttctga tttgaatgac ctttatcgtc gtgtcatcaa 125941 ccgtaacaat cgtttgaaac gccttttgga ccttggtgcg cctagcatca tcgttcaaaa 126001 cgaaaagcgt atgcttcaag aggctgtcga tgccctaatt gacaacggcc gccgcggacg 126061 ccctgtaaca ggtcctggaa acagaccgtt aaaatctctt tctcacatgc tgaaagggaa 126121 gcaaggccgt ttccgtcaaa accttcttgg taaacgtgtc gattactccg gacgttctgt 126181 aatcgttgtt ggtcctcatt tgaaaatgta ccaatgcgga ttaccgaagg aaatggcact 126241 tgaacttttc aaacctttcg ttatgaaaga acttgttgaa aaaggtcttg ctcacaacat 126301 taagagtgcg aaacgcaaaa ttgagcgcgt acagcctgaa gtttgggatg tactagaatc 126361 agttattaag gagcatccgg tactgctgaa ccgtgcccct acacttcaca gattaggtat 126421 ccaggcgttt gaaccaacgc ttgttgaagg acgcgcaatc cgtcttcacc cgctcgtatg 126481 tacagcttac aacgctgact ttgacggtga ccaaatggcg gttcacgtac cattatctgc 126541 tgaagcacaa gctgaagcac gcatcttgat gcttgctgct caaaacatct tgaaccctaa 126601 agatggtaaa ccggttgtaa caccgtctca ggatatggta ctaggtaact attacctgac 126661 acttgagcgt gccggtgctg tcggtgaagg tatggtcttc aagaatacag acgaagcgct 126721 tcttgcttat caaaacggat atgttcacct tcatacgaga gtagctgttg cagctaactc 126781 acttaagaat gtgacattta ccgaagaaca gcgctcaaaa ttgttaatta caactgtcgg 126841 taagcttgtc ttcaatgaaa ttcttccgga atcattccct tacatgaatg aaccaacgaa 126901 gagcaacatt gaagagaaaa cacctgaccg tttcttctta gaaaaaggtg ctgatgttaa 126961 agctgttatc gcacagcagc caatcaatgc gccgtttaaa aaaggcattc tgggtaaaat 127021 catcgcggaa atctttaaac gattccatat tacggaaacg tctaaaatgc ttgaccgcat 127081 gaaaaaccta ggtttcaaat attcaactaa agctggtatt acagttgggg tttctgacat 127141 cgtcgtactc gatgataaac aagaaattct tgaggaagcg caaagcaaag ttgacaacgt 127201 tatgaagcaa ttccgccgcg gtcttatcac tgaagaagaa cgctatgaga gagtcatctc 127261 tatctggagt gctgcaaaag acgttatcca aggcaaactg atgaaatcac ttgatgaact 127321 caacccgatc tacatgatga gtgactctgg tgcccgtggt aacgcatcta actttacgca 127381 gcttgccgga atgcgcggcc tgatggccaa cccggctgga cgtatcattg agttgccgat 127441 caaatcaagt ttccgtgaag gtctgacagt attggagtac tttatctcca cacacggtgc 127501 gcgtaaaggt cttgccgata ccgctcttaa aactgctgac tcaggttacc ttacacgccg 127561 tctcgttgac gttgctcagg atgttatcat ccgtgaaact gattgcggaa ctgaccgagg 127621 cattcttgct aagcctctta aagaaggaac tgaaacaatt gagcgcttag aagaacgctt 127681 aatcggacgt tttgcaagaa aacaagtgaa gcaccctgaa acaggtgaag tgcttgtgaa 127741 tgaaaacgaa ctgatcgatg aagataaagc actggagatt gtcgaagccg gcattgaaga 127801 agtgtggatc cgttctgcct tcacatgtaa tacgcctcat ggtgtatgta aacgatgcta 127861 tggccgaaat cttgcaactg gctccgatgt tgaagtcggt gaagctgtcg gaatcattgc 127921 tgcccaatca atcggtgagc ctggtacaca gttaacaatg cgtacattcc atacaggcgg 127981 ggttgccgga gacgatatca cacagggtct tccgcgtatc caagagcttt tcgaagcgcg 128041 taatccgaaa ggtcaggcaa caattacaga aatcgacggt acagtcgttg agatcaatga 128101 agttcgtgat aagcaacagg aaattgtggt tcaaggcgca gtggaaacac gttcttatac 128161 ggcaccttac aactcccgcc tgaaagtagc ggaaggagat aaaattactc gaggccaagt 128221 actgacagaa ggttcaatcg atccgaaaga acttcttaaa gtgactgacc tgacgactgt 128281 tcaagagtat cttctccatg aggttcaaaa ggtttaccgt atgcagggtg ttgaaatcgg 128341 tgataaacac gtagaagtaa tggttcgcca gatgcttcgc aaagtacgcg tgattgatgc 128401 cggtgacact gatgtgcttc caggtacatt gcttgatatt caccaattta ctgaagcgaa 128461 caaaaaggta ttgcttgaag gcaaccgacc agctacaggc cgtcctgtct tactcggtat 128521 tacaaaagca tctcttgaaa ctgattcatt cttatctgct gcttccttcc aggaaacaac 128581 acgtgtcctt acagatgcag cgatcaaagg taagcgtgac gagcttctcg gcttgaaaga 128641 gaatgttatc atcggtaagc ttgttccagc aggtacagga atgatgaaat accgtaaagt 128701 aaaaccagta tcaaatgttc agccgactga cgatatggtc ccggttgaat aactgattta 128761 actctgctga aagactgcaa aaacagtctt tcagcagata tatttatgaa aaagtcactc 128821 tatgagaaga acgaatctaa aaaatgtcat accttgttga cattcgtctc ctagaatgat 128881 aatataacca aggtgctcga aataaacctg ttactttgga ggatatgttt atgtcttatg 128941 ataaagtatc acaggccaaa tcaattatta ttggtacgaa gcaaacagtg aaagctctaa 129001 agcgaggttc agtaaaggaa gtagtcgttg caaaagacgc agatccgata ctcacgtcaa 129061 gtgttgtttc acttgctgaa gatcaaggta tctctgtctc aatggttgaa tccatgaaaa 129121 agctcggcaa agcctgcgga attgaggtag gagcagccgc tgttgccatt attttataac 129181 gtacttttgt ttttgcgtaa gattccatct tgtgtaaaga cattgttttt tgccttttga 129241 tgaaccacct gggtatgtgg gttataaaac gtaatgaagg gaggaaaaat tcatgcctac 129301 aattaatcag ctaattcgca aaggacgcgt gagtaaagta gaaaactcaa agtctcctgc 129361 acttaacaaa ggatacaaca gctttaaaaa agagcacact aacgtatctt ctccacaaaa 129421 acgcggggta tgtactcgtg ttggtacaat gacaccgaaa aaaccgaact cagcacttcg 129481 taaatatgct cgtgttcgtt tgactaacgg aatcgaggtt actgcttaca ttcctggtat 129541 cggtcacaac ctgcaagagc acagtgttgt acttatccgc ggcggacgtg taaaagactt 129601 accaggggta cgttaccaca tcgttcgtgg tgcgcttgat actgctggag ttgaaaaccg 129661 tgcacaaggc cgttctaaat acggtacgaa aaaacctaaa gcaaaataat atacgaaaat 129721 acgcataatt gatgaaggga ggatattcag atgccacgta aaggtcctgt agcaaaaaga 129781 gatgttttac ctgatccgat ttacaactct aagcttgtat ctcgtttaat caacaaaatg 129841 atgatcgatg gtaaaaaagg taagtctcaa acgatcctat acaagtcatt cgatatcatt 129901 aaagaacgta ctggcaatga tgcaatggag gttttcgaac aagcattgaa aaacatcatg 129961 cctgtacttg aagtaaaagc acgccgtgta ggtggtgcga actaccaagt tcctgtagaa 130021 gttcgtcctg aacgtcgtac gactcttgga cttcgctggt tagttaacta cgctcgtctt 130081 cgtggagaaa aaacgatgga agagcgttta gctaacgaaa tccttgacgc agctaacaac 130141 actggtgctg ctgttaagaa acgtgaagac actcataaga tggctgaagc aaacaaagca 130201 tttgctcact atcgctggta ggatttatag attaacaaaa cacaatttcc taataaggaa 130261 ggagaaatta cccaatggca agagagttct ccttagaaaa aactcgtaat atcggtatca 130321 tggctcacat cgatgccggt aaaacgacta ctacagaacg tatcttgttc tatactggtc 130381 gtatccacaa aattggtgaa actcatgaag gagcttcaca aatggactgg atggagcagg 130441 aacaagaacg tggtatcaca atcacttccg ctgcgactac tgcacagtgg aaaggatacc 130501 gcgtaaacat catcgatact ccaggacacg tagacttcac agttgaagtt gaacgttctc 130561 ttcgtgtact tgatggtgct gttgctgtac ttgacgcgca atcaggcgtt gagcctcaaa 130621 cagaaactgt ttggcgtcag gcaacaactt atggagtacc gcgtatcgtt tttgttaaca 130681 aaatggacaa aatcggtgca gacttccttt actctgtagg aactttaaga gaccgtcttc 130741 aagcaaacgc tcatgcaatt caattgccga tcggtgctga agataacttc gaaggtatca 130801 ttgaccttgt agaaaacgtt gcgtatttct acgaagatga cctcggaact cgttctgatg 130861 caaaagaaat ccctgaagag tacaaagagc aagctgaaga gcttcgcaac agccttattg 130921 aagctgtatg tgagcttgat gaagagctta tggataagta ccttgagggt gaagaaatca 130981 caattgacga gttaaaagca ggaattcgta aaggtacatt aaatgttgaa ttctaccctg 131041 ttcttgttgg ttctgccttc aaaaacaaag gtgttcaact agtacttgat gctgttcttg 131101 actaccttcc tgcaccaact gacgttgctg caatcaaagg tacacgtcct gatacaaatg 131161 aagagattga gcgtcattct tctgacgaag agccattctc tgcattagca tttaaagtta 131221 tgactgaccc ttacgttggt aagttgacgt tcttccgtgt gtactctgga acacttgatt 131281 ctggttcata cgtgaaaaac tctactaaag gcaaacgtga gcgtgttgga cgtattcttc 131341 aaatgcacgc taacagccgt gaagaaatct ctactgtata cgcaggggat atcgcagctg 131401 ctgtaggtct aaaagataca actactggag atactctatg tgatgagaag gatcttgtta 131461 tccttgagtc aatggaattc ccagaaccag ttatcgacgt tgctattgag cctaaatcaa 131521 aagctgacca agataaaatg ggtatcgctt tagcgaaact tgctgaagaa gatcctacat 131581 tccgtactca aacaaaccca gaaactggcc aaacgatcat ctctggtatg ggtgaacttc 131641 accttgatat cattgttgac cgtatgaaac gcgaatttaa agtagaagcc aatgttggtg 131701 ctcctcaagt tgcgtaccgt gaaacattcc gtaccggtgc aaaagttgaa ggtaaattcg 131761 tacgtcagtc tggtggacgc ggtcagttcg gacacgtttg gatcgaattc gaaccaaacg 131821 aagaaggcgc tggctttgaa tttgaaaatg cgattgtcgg tggggtcgtt cctcgtgaat 131881 acatcccagc tgttcaagca ggtctggaag atgcactcga aaatggtgta ctagcaggct 131941 tcccgcttat cgacattaaa gctaaacttt tcgacggttc ttaccatgat gttgactcaa 132001 acgaaatggc atttaaagtc gctgcttcta tggcattgaa aaatgcagtc agcaaatgta 132061 acccagttct tcttgaacca atcatgaaag tggaagtggt tattccagaa gaatatatgg 132121 gagatatcat gggtgatatc acttcacgtc gcggacgcgt agaaggtatg gaagcacgcg 132181 gtaacgctca agttgttcgt gctatggttc ctcttgctga aatgttcggt tacgctactg 132241 cacttcgttc taatacgcaa ggtcgcggta cgttcactat gcacatggat cactacgaag 132301 aagtgccgaa gagcgtcgca gaagaaatta tcaaaaaaaa taaaggcgaa taattgattt 132361 tgccgcttaa ctcaagtata actactattg taagatgagg aagtgaaagc tttctttcac 132421 ttcctatcac tctatacatt actaattaaa agctcttaag gaggatttta gaatggctaa 132481 agaaaaattc gaccgttcca aatcacatgc caatattggt acaattggac acgttgacca 132541 tggtaaaaca actttaactg ctgctatcac aacagtactt cataagaaat ctggtaaagg 132601 tacagctatg gcgtacgatc aaattgatgg tgctccagaa gaacgcgagc gcggtatcac 132661 aatctctact gcacacgttg agtacgaaac tgaaactcgt cactatgcac acgttgactg 132721 cccaggacac gctgactatg ttaaaaacat gatcactggt gctgcgcaaa tggacggagc 132781 tatccttgta gtatctgctg ctgatggccc aatgccacaa actcgtgagc acatccttct 132841 ttctaaaaac gttggtgtac catacatcgt tgtattctta aacaaatgcg acatggtaga 132901 cgacgaagag cttcttgaac tagttgaaat ggaagttcgc gatcttctta gcgaatacga 132961 cttccctggt gatgatgtac cagttgttaa aggttctgct cttaaagctc ttgaaggaga 133021 cgctgagtgg gaagctaaaa tcttcgaact tatggatgcg gttgatgagt acatcccaac 133081 tccagaacgc gacactgaaa aaccattcat gatgccagtt gaggacgtat tctcaatcac 133141 tggtcgtggt acagttgcta ctggccgtgt agaacgcgga caagttaaag tcggtgacga 133201 agttgaaatc atcggtcttc aagaagagaa caagaaaaca actgttacag gtgttgaaat 133261 gttccgtaag cttcttgatt acgctgaagc tggtgacaac attggtgccc ttcttcgcgg 133321 tgtatctcgt gaagaaatcc aacgtggtca agtacttgct aaaccaggta caatcactcc 133381 acacagcaaa ttcaaagctg aagtttacgt tctttctaaa gaagagggtg gacgtcatac 133441 tccattcttc tctaactacc gtcctcagtt ctacttccgt acaactgacg taactggtat 133501 catccatctt ccagaaggcg tagaaatggt tatgcctgga gataacactg aaatgaacgt 133561 tgaacttatt tctacaatcg ctatcgaaga aggaactcgt ttctctattc gtgaaggcgg 133621 acgtactgtt ggttcaggcg ttgtttctac aatcactgag taatagtatg gttttaaacg 133681 agacccctgt gggtctcgtt ttttgtttgc ttatcttttt cttgtataat aggatctatc 133741 atattcgagg ggttaatatt tatgattcct gaaaagaaat caatcgcaat catgaaagaa 133801 ctaagcattg gaaatacaaa gcaaatgctg atgattaatg gagttgacgt gaaaaatcca 133861 ttgctgcttt ttttacatgg cgggccggga acgccgcaaa tcggatatgt tagacattat 133921 caaaaagagc tggaacagta ttttacagta gttcattggg atcagagagg atcggggctt 133981 tcttattcta agcgaatttc gcatcactct atgacaataa atcacttcat taaagataca 134041 atccaagtca ctcaatggct tttagctcat ttttcaaaat caaaacttta cctagccggt 134101 cattcttggg gatcaatact ggcgcttcat gtgctgcagc agcgtcctga tttattttac 134161 acgtattatg gaatcagcca ggttgttaac ccgcaagatg aagaatcaac tgcttatcaa 134221 catattcgtg aaatttccga atcaaaaaaa gccagcatat tatctttcct tacacgtttc 134281 attggtgctc cgccttggaa gcaggatatc cagcacctta tctatcggtt ttgtgttgag 134341 ctaaccaggg gaggattcac tcaccgtcat cgtcaatctc tcgctgtatt atttcaaatg 134401 cttactggca atgagtatgg agtgcggaac atgcacagct tccttaatgg attgcgcttc 134461 agtaaaaaac atttaactga tgagttgtac cggtttaatg cttttacatc agttccttct 134521 attaaagtac cgtgtgtttt catttcaggg aaacatgact taattgttcc tgcagaaata 134581 tcgaaacagt attatcaaga acttgaggca cctgaaaagc gctggtttca atttgagaat 134641 tcagctcaca ccccgcatat tgaggagcca tcattattcg cgaacacatt aagtcggcat 134701 gcacgacacc atttatgata gatccttgat aaataagaaa aacccctgta taataaaaaa 134761 agtgtgcaaa tcatgcatat tttaaataag tcttgcaaca tgcgcctatt ttctgtataa 134821 tggtgtatgt tggtctttga ctgcgatgaa gtgagaggtt gctgacacac ccggccgctt 134881 tgccatggca aggtgttcag gtttttctca cggagaactg tctaacgtga tgtaggcgaa 134941 aaggagggaa aataatggca aaacaaaaaa ttcgtattcg tttgaaagca tatgatcata 135001 gaatccttga tcaatctgca gagaagattg ttgaaacggc aaaacgttct ggtgccagcg 135061 tatctggtcc gattccgttg ccaactgaaa aatcagttta cacaatcctt cgtgcggtgc 135121 acaaatacaa agattctcgt gagcaatttg aaatgcgtac acataaacgt ttaatcgaca 135181 ttgtgaaccc aacaccacaa actgttgatg ctcttatgcg attagactta ccatctggtg 135241 tcgatatcga aattaaactt taattctaaa atatagaatg atcttaatag gaggtgtgac 135301 gaatgaccaa aggaatctta ggaagaaaaa ttggtatgac gcaagtattc gctgagaatg 135361 gtgatcttat tccggtaact gttatcgagg ctgctccaaa cgttgttctt caaaagaaaa 135421 cagctgaaaa cgacggttac gaagcaatcc agcttggttt tgacgacaag cgtgaaaagc 135481 tttctaacaa acctgaaaaa gggcacgttg caaaagcgga aactgctcct aagcgcttcg 135541 ttaaagaatt acgcggagtg gaaatggatg cgtatgaagt tggtcaggaa gtcaaggttg 135601 aaattttctc tgctggagaa atcgtagatg taacaggagt atctaaaggt aaaggtttcc 135661 aaggtgcgat caagcgccac ggacaatctc gcggacctat gtctcacggt tcacgctacc 135721 accgtcgtcc tggttcaatg ggacctgtag atcctaaccg tgtattcaaa ggtaaattat 135781 tacctggacg tatgggcgga gagcaaatca ctgttcaaaa ccttgaaatc gtaaaagttg 135841 atgcagaacg caatcttctt ttgatcaaag gtaacgtacc tggtgcgaag aaatctttaa 135901 tcactgttaa aagtgctgtt aaatctaaat aattctctta ggaaaggagg aaattgatta 135961 tgccaaaagt agcattatac aaccaaaacg gttctactgc tggtgacatc gaattaaacg 136021 cttctgtatt tggtatcgaa ccaaatgaga gtgttgtatt cgacgctatt cttatgcaaa 136081 gagcttcctt acgtcaagga actcacaaag taaaaaatcg ttctgaagta cgcggcggag 136141 gtcgtaaacc atggcgtcaa aaaggtactg gacgtgcccg tcaaggttca atccgttcac 136201 cgcaatggcg cggaggtggt gtcgtattcg gcccaacacc acgcagctat tcttataaat 136261 tacctaaaaa agttcgccgc ttggcaatca aatcagtatt gtcttctaaa gtgatcgaca 136321 acaacatcat cgttcttgaa gatcttactc ttgatacggc taaaacaaaa gaaatggcag 136381 ctatccttaa aggattatct gttgagaaaa aagctttaat cgtaactgcg gatgcaaacg 136441 aagcagtagc attatctgct cgtaacattc ctggagttac tgttgttgaa gctaacggaa 136501 tcaacgtttt agacgttgtc aaccacgaga agcttctgat tacaaaagca gcggttgaaa 136561 aagtagagga ggtgcttgca taatgaaaga tcctcgtgat gttctaaagc gccccgtcat 136621 tactgaacgt tctgccgatt taatgactga aaaaaaatat acttttgaag ttgatgtaag 136681 agctaacaaa acagaagtga aagacgcggt tgaaagcatc tttggagtga aagttgacaa 136741 agtcaacatc atgaactaca aaggcaaatc aaaacgtgtt ggacgctaca ctggtatgac 136801 tagccgtcgc agaaaagcga tcgtaaaact tactgcagac agcaaagaaa tcgaaatttt 136861 tgaagcttaa ttatctgtaa aaagaaggag ggaaattcaa aatggcgatt aaaaagtata 136921 aaccgacctc taatggacgt cgtggcatga caacttcaga ttttgctgaa atcacgactg 136981 acaagccgga aaaatccttg cttgctcccc ttcacaaaaa aggcggacgt aacaaccaag 137041 gtaaattgac tgtacgtcac caaggtggcg gacataaacg ccaataccgt gttatcgact 137101 tcaaacgcga taaagatggt atacctggac gcgttgctac agttgaatac gatccaaacc 137161 gttcagctaa catcgctcta atcaactatg cagacggaga aaaacgttac attcttgctc 137221 ctaaaggaat tcaagtaggt actgaaatca tgtcaggtcc tgaagctgac attaaagtag 137281 gtaatgcact tccacttatc aacatccctg ttggtacagt tgtgcataac attgaattaa 137341 aacctggtaa aggcggacag cttgtacgtt cagctggtac atctgctcag gttcttggta 137401 aagaaggtaa atacgttctt gtacgtctta actctggtga agttcgcatg atcctttctg 137461 cttgccgtgc ttctatcggt caagtaggta acgaacagca cgaacttatc aacattggta 137521 aagctggacg ttctcgctgg aaaggcatcc gtcctacagt tcgtggttct gtaatgaacc 137581 ctaacgatca cccacacggt ggtggtgaag gacgtgcgcc aatcggacgt aaatcaccaa 137641 tgtctccatg gggcaaacca actcttggat tcaagactcg taagaaaaag aacaaatccg 137701 ataaatttat cgtacgtcgt cgtaaaaata aataacgggg ttgtctacgg ttcttttcgg 137761 accgtagtgc aatcacgaag ggaggttcca aaatggctcg cagcttaaaa aaaggaccat 137821 ttgtcgatgg acacttgatg actaaaatcg agaaattaaa tgaaacagac aagaaacaag 137881 tcgtaaaaac ttggtctcgt cgttctacta ttttcccaca gtttattggt cacacaatcg 137941 cagtctatga cggacgtaaa cacgtgcctg tattcatctc tgaagatatg gtagggcaca 138001 agttgggtga attcgctcca actcgtacgt acaaaggtca tgctagtgat gacaaaaaaa 138061 caagacgcta agagaggagg cttttaaatg caagctaaag ctgttgcaag aacagtccgt 138121 attgctcctc gtaaagcacg tctagtaatg gacctgattc gaggcaagca agtaggtgag 138181 gcagtatcaa tcttgaacct tacaccaaga gctgcttctc caattatcga gaaagtatta 138241 aaatccgcta ttgcaaatgc tgagcataac tatgaaatgg acgctaacaa cctggttatt 138301 tctcaagcat tcgttgacga aggccctacg ttaaaaagat tccgcccacg tgctatggga 138361 cgtgcgagcc aaatcaacaa acgtacgagc cacattacaa tcgttgtatc agaaaagaag 138421 gagggataag tagtgggtca aaaggtaaat ccagtcggtc ttcgtatcgg agtcattcgt 138481 gattgggaat ctaagtggta cgctggtaaa gattacgctg acttcctgca cgaagattta 138541 aaaattcgtg aatacattag caaacgcctt tctgacgctt ctgtttctaa agtagaaatt 138601 gagcgtgcag caaaccgcgt taacattacg atccacacag ctaagcctgg tatggttatc 138661 ggtaaaggcg gttctgaagt cgaagcactt cgcaaagccc ttaacagcct tactggcaag 138721 cgtgtacaca ttaacattct tgaaatcaaa agagcagatc ttgatgcaca gctagttgct 138781 gacaacatcg ctcgtcaatt agaaaaccgt gtttctttcc gccgtgcgca gaaacaacaa 138841 atccaacgta ctatgcgtgc tggagcacaa ggtgtgaaaa caatggtttc tggtcgtctt 138901 ggcggtgcag atatcgctcg ttctgaatac tacagtgaag gaactgttcc attgcacaca 138961 ttacgtgcgg acattgacta tgcaacatct gaagctgata ctacttacgg taagcttggt 139021 gtaaaagtct ggatctatcg tggagaggtt cttcctacta agaagaaaaa tgaggaagga 139081 ggaaaataat atgttattac caaaacgcgt taaatatcgc agagagcatc gcggaaaaat 139141 gcgtggccgt gcgaaaggcg gtactgaagt acatttcgga gaattcggta tccaagctct 139201 agaagcttct tggattacta accgtcaaat cgaagctgca cgtattgcga tgactcgtta 139261 catgaaacgt ggcggtaaag tttggatcaa aattttccct tctaaacctt acactgctaa 139321 accacttgag gtacgtatgg gatccggtaa aggggctcca gaaggttggg tagctgttgt 139381 aaaaccgggc aaagttttat ttgaaatttc tggtgtgtct gaagaggttg ctcgtgaagc 139441 gcttcgcctt gcatctcaca aattgccaat taaaacgaag ttcgtaaaac gtgaagaaat 139501 tggtggtgaa tcaaatgaaa gctaatgaaa ttcgtgacct taccactgct gaaattgaac 139561 aaaaagtaaa gtctcttaaa gaagaacttt tcaatcttcg ctttcaatta gcgacaggac 139621 aacttgaaaa tactgctcgc attcgtgaag tgcgcaaagc tatcgcgcgc atgaaaactg 139681 tgattcgtga aagagaaatt gctgctaata aataatcact gaggggaggt cgtgagcatg 139741 agcgaacgta accaacgcaa agtttaccaa ggccgtgttg tttctgacaa aatggataaa 139801 accattactg ttgttgttga gacatacaaa aaacatacac tttacggtaa acgcgtaaaa 139861 tactcaaaaa aattcaaagc acatgatgaa aataatcaag ctaaaatcgg tgacatcgtt 139921 aagatcatgg aaactcgtcc attgtctgca actaagcgtt tccgtctagt tgaagttgtc 139981 gaagaagctg ttattatcta ataaagttcg gaattctttt tccgaaggga ggtaacaaat 140041 aatgattcaa caagagactc gtttaaaagt agctgacaac tctggcgcac gtgaagtact 140101 tactattaaa gttcttggtg gttctggacg taaaacagct aacattggtg atgtaattgt 140161 ttgcacggtt aaacaagcaa caccaggagg cgttgtcaaa aaaggtgaag tcgtaaaagc 140221 tgttatcgtt cgcactaaaa gcggagcgcg cagaagtgac ggttcataca tcagcttcga 140281 tgagaatgca tgtgttatca tccgtgacga caagagccca cgcggaactc gtatcttcgg 140341 accagttgct cgtgaattgc gtgaaaacaa ctttatgaaa attgtttctc tagctccaga 140401 agttatctaa ttgaaataaa tgccttactc aaggaggtgc gatcaggatg catgtaaaaa 140461 aaggcgataa agttatggtt atctctggta aagataaagg caaacaagga acaatccttg 140521 ctgctttccc taaaaaggac cgcgttttag ttgaaggtgt taacatggta aagaaacact 140581 ctaaaccaac tcaagctaac cctcaaggcg gtatttctaa tcaagaggcg ccaattcatg 140641 tatcaaacgt tatgccgctc gatcctaaaa caggtgaagt gactcgcgta ggatacaaag 140701 tggaagatgg caaaaaagtt cgtgtagcaa aaaaatctgg gcaagttcta gataaatagt 140761 attaaaagga agggaggtct atctcatgaa ccgccttaaa gaaaagtaca ataaagaaat 140821 tgcacctgct ttaatgacta agttcaacta tgattcagtc atgcaagtgc ctaaaatcga 140881 aaaaatcgta atcaacatgg gtgttggtga cgctgttcaa aacgccaaag caatcgacag 140941 tgctgttgag gaattaacgt ttatcgcagg tcaaaaacct gtcgttactc gtgcgaagaa 141001 atcaattgct ggattccgtc ttcgtgaggg aatgcctatc ggtgcgaaag taactcttcg 141061 cggagagcgc atgtatgatt tccttgataa acttatttct gtatctttac cgcgtgtacg 141121 tgacttccgc ggggtttcta aaaaatcttt cgacggtcgc ggtaactaca cacttggtat 141181 caaagaacag ttaatcttcc ctgaaattga ctacgataaa gtaacaaagg ttcgcggaat 141241 ggacatcgtt atcgtaacaa ctgctaatac tgacgaagaa gctcgtgagc tattaactca 141301 agtaggtatg ccgttccaga aataatcaat gaaagggagg cgaaatcgtg gctaaaaagt 141361 ctatgattgc gaaacaacaa cgtacaccaa agtttaaagt acaagagtac acacgctgtg 141421 aacgctgcgg acgtccgcat tcagtcattc gtaaatttaa actttgccgt atttgtttcc 141481 gtgagcttgc atataaagga caaattcctg gcgtgaaaaa agccagctgg taatccccaa 141541 gaaagggaag gaggtaatta tataatggtt atgacagatc caattgcaga tatgctaact 141601 cgtattcgca atgcaaacat ggtacgtcat gagaagcttg aaattcctgc ttctaaattg 141661 aaaagagaaa ttgctgaaat tttaaagcgt gaaggtttca ttcgtgacgt tgagttcgta 141721 gaagacagca aacaaggtat tatccgcgtt ttcttgaaat acggacaaaa caacgagcgc 141781 gttatcactg gtcttaaaag aatcagcaag cctggtttgc gtgtttatgc taaatctaat 141841 gaagtacccc gcgtacttaa cggtcttgga atcgcgatta tttctacatc acaaggtgtt 141901 ttaacggaca aagaagcccg tgcaaaacaa gctggtggag aagttctagc atacgtttgg 141961 taagaagttt aacatgaatg gaggtgtttg gtatgtctcg tgtaggtaag aagctacttg 142021 agattccttc tgatgttaca gtaacgttaa atgataacaa cactgtagct gtgaaaggac 142081 caaaaggaga attaactcgt acgtttcacc ctgatatgga gattaaagta gaggacaatg 142141 tgcttacagt cgctcgtcct tctgatcaaa aagagcaccg tgccctgcat ggtacgactc 142201 gcagtctgct tggcaacatg gttgaaggtg tatctaaagg atttgaaaga ggtttggaat 142261 tagtcggtgt cggttaccgt gcttctaaat ccggaaataa acttgtttta aacgttggat 142321 actctcatcc tgttgagatc gttcctgaag aaggcatcga aatcgaagtt ccttctcaaa 142381 caaaagtagt tgtaaaaggt acagacaaag aacgcgtagg agctattgct gctaacatcc 142441 gcgctgtacg ttctccagag ccttacaaag gtaaaggaat ccgctacgaa ggtgaagttg 142501 ttcgccgtaa agaaggtaaa tctgctaagt aagatcgctt aaagtgaaga aaggagtgac 142561 ctagatgatt acgaaaacta gcaaaaatgc tgctcgtctt aaaagacacg ctcgtgttcg 142621 cgctaaactt tccggtactg ctgaaagacc gcgcctgaac gttttccgtt ctaacaagca 142681 catttacgct caaatcatcg atgatgtaaa tggtgtaaca cttgctagtg catctactct 142741 cgataaagac ttgaacgttg aaagcactgg agatacttct gctgctacta aagttggaga 142801 attagttgca aaacgcgctg ctgaaaaagg catttctgac gtagtatttg accgtggcgg 142861 atacttatac catggacgtg taaaagcttt ggctgatgcc gctcgtgaag ctggacttaa 142921 attttaataa aagaaggagg gacacatgat tatgcgtcgt attgacccaa gcaaattaga 142981 gttagaagaa cgcttagtta cggttaaccg cgtagcgaaa gttgttaaag gtggtcgtcg 143041 tttccgcttc gcagctctag tcgttgtcgg tgacaaaaac ggacacgtag gattcggtac 143101 tggtaaagca caagaagtac cagaagcgat tcgcaaagct gttgaagatg cgaaaaagaa 143161 tttgattgaa gtaccaatgg ttggaactac aattccacac gaaatcatcg gacgtttcgg 143221 tgcaggtaac atcttgttaa aacctgcttc tgaaggtact ggagttatcg ctggaggccc 143281 tgtacgtgcg gtacttgagc tagctggtgt agctgatatc ctttctaagt ctttaggttc 143341 taacacaccg atcaacatga ttcgtgcaac acttcaaggt ttaagtgaac ttaaacgtgc 143401 tgaagacgtt gcgaagcttc gtggaaaatc tgtagaagaa ctgttaggat aaggagggaa 143461 cattaatggc taaattagaa attaccctca aacgaagtgt aatcggtcgc ccggaagacc 143521 aacgcgttac tgtaagaaca cttggtttaa agaaaacaaa ccaaactgtt gttcatgaag 143581 acaacgctgc gatccgtggt atgattaata aagtatctca tttagtttct gttaaagaac 143641 aataaaaata tttgatcgga taaggaggtg tcctaatgaa acttcatgaa ttaaaacctt 143701 cagaaggttc acgcaaaacg cgtaatcgcg taggtcgtgg tattggttct ggcaacggta 143761 aaacagctgg taaaggtcac aaaggtcaaa acgctcgttc tggcggcggt gtacgccctg 143821 gattcgaggg gggacaaatg cctttattcc aacgtcttcc taaacgtggt ttcactaaca 143881 tcaaccgcaa ggaatacgct gtagtcaacc tagacaaatt gaacggtttt gcagaaggaa 143941 cggaagtcac tcctgaactt cttctagaga ctggtgttat tagcaaactt aatgcaggag 144001 taaagattct tggcaacggt aaattagaga aaaaattaac tgtaaaagcc aataaattct 144061 ctgcttctgc gaaagaagct gttgaagctg ctggcggtac agctgaggtg atctaacttg 144121 tttaaaacaa tctccaactt tatgcgtgtg agtgatatca ggaataaaat catattcact 144181 ttactcatgc ttatcgtctt tcgcataggt gcgtttattc ctgtgcctta cgttaacgct 144241 gaagcgttac aggcacagtc tcaaatgggt gtttttgatc tccttaatac atttggcggc 144301 ggtgcgcttt accaattttc cattttcgca atgggaatta ctccttatat cacggcttcg 144361 atcatcattc agctgcttca gatggatgtg gtaccgaagt ttaccgagtg gtctaagcaa 144421 ggtgaagttg gccgccgtaa attagctcag ttcacaaggt actttacgat tgtgcttggt 144481 ttcatccaag cgttaggtat gtcatatgga ttcaacaatc tggcaaacgg tatgctgatc 144541 gaaaaatccg gtgtatcgac atatcttatc attgctttag tgctcactgg cggaactgcc 144601 tttttaatgt ggcttgggga acaaattact tctcatggag taggcaacgg aatatcgatc 144661 attatcttcg cggggattgt gtctagtatt ccaaaaacaa ttgggcaaat atatgagact 144721 caatttgtcg gcagcaacga tcagttgttt attcatattg tgaaagtcgc acttcttgtg 144781 attgcgattt tagcagttat tgttggagtt attttcattc agcaagccgt acggaaaatt 144841 gcgattcaat atgctaaagg cacaggtcgt tcacctgctg gcggaggtca gtctacacac 144901 cttccattga aagtgaatcc tgcaggggtt attccggtaa tctttgcggt tgcgtttttg 144961 ataacgccgc ggacgatcgc gtcattcttt ggaacaaacg atgtgacaaa gtggattcaa 145021 aacaactttg ataatacgca tccggtgggt atggcgatat atgttgcgtt gattattgcc 145081 tttacgtact tttatgcttt tgtacaggta aaccctgaac aaatggctga taaccttaaa 145141 aaacagggtg gctatatccc gggggttcgt ccagggaaaa tgactcaaga tagaattacg 145201 agcattttgt atcgacttac gtttgtgggt tctatattct tagccgtgat ttccattctt 145261 cctatctttt tcattcaatt cgctggattg cctcaaagtg cacaaattgg cggaacatct 145321 ttgttaattg ttgtcggggt agccttggag acaatgaaac aactagaaag ccagttggtg 145381 aaacgaaact accgtggatt tatgaaaaac tagaggaaat ggatttatcc attccctctt 145441 aataaagaga ggacggggga aatccgaatg aacttagtct taatggggct tcctggtgcc 145501 ggtaaaggca cacagggcga acgaattgtt gaggattatg ggattcctca tatctcaaca 145561 ggagatatgt tccgtgctgc tatgaaagaa gaaacaccac tcggactcga agcaaaatct 145621 tatattgata agggagagct cgtacctgac gaagtcacaa tcggaattgt aaaagagaga 145681 cttggcaaag atgattgtga aagaggtttt cttctggacg gatttccgcg aacagtcgct 145741 caagccgaag ctcttgaaga aattcttgag gaatacggca agccgattga ttatgtcatt 145801 aacattgaag tcgacaaaga tgttctgatg gaacgtctga ctggacgcag aatttgcagt 145861 gtttgcggca caacctatca tttagtcttt aatccgccga aaacgccggg tatttgtgat 145921 aaagacggag gcgaactcta tcaacgggca gatgataatg aggaaacagt ctctaaacgg 145981 cttgaggtaa acatgaagca aactcagcct ttactcgatt tctattcaga gaaaggttat 146041 cttgcaaacg tgaatggcca gcaggacatt caagacgttt atgcagatgt gaaggatctt 146101 cttggaggat taaaaaaatg attatctgta aaaccccacg tgaacttggt atcatgcggg 146161 aagcagggcg aatcgtggct ttaactcatg aagagttaaa aaagcacatt aaaccaggaa 146221 tctcgacaaa agaattggat caaattgccg aacgttttat taagaagcag ggtgcaatcc 146281 catcttttaa ggggtataat gggtttcgcg ggagcatttg cgtatcagtt aatgaagaac 146341 tcgttcacgg catacctggc agcagggtgc tgaaggacgg tgacatcatc agtattgata 146401 tcggtgctaa attaaatggt tatcatggtg actctgcatg gacatatccg gtaggaaaca 146461 tcagcgatga tgacaaaaaa cttctggaag tgacagagga gtctttatat aaaggcttgc 146521 aggaagcaaa accaggtgaa cgtttgtcga atatttccca cgcaatacaa acgtatgtcg 146581 aaaatgagca gttttcagtt gttagggagt atgtcggaca tggtgttggt caagacttgc 146641 atgaggaccc gcaaattcct cattacggtc cgcccaacaa aggaccacgg cttaaacctg 146701 gcatggttct cgctattgaa cctatggtga acgctggcag ccgctacgtg aaaacattgg 146761 ctgataactg gacggttgta acggtagatg ggaaaaagtg tgctcatttt gaacatacga 146821 ttgcgattac ggaaacgggt tttgatatac tgacgagagt ctagatgatg aaaataattc 146881 cgaagacaga tgtttttcaa gcttgatagg gcagaaagct tgggtgaaca ttggcaagac 146941 cgaattcatc ttgcttcttg tcgttggaat tttaaccatc atcaatgtac taacagcaga 147001 cggagaaaag cgtacatttc attctcctaa gaaaaagaat atcaatcatt taacccttta 147061 tgattgcgta tctccggaag ttcagaacag tataaacgaa acagggcgtg tgacaaactt 147121 cttttgaaat ttgtcagaaa gcaagttact gatttgaaga agggagaaca cttgaatggc 147181 gaaagacgat gtaattgaag tggaaggtac tatagtcgaa acactgccaa acgcgatgtt 147241 caaagttgaa cttgaaaatg gccacactgt tttggctcat gtatctggta aaatccgcat 147301 gcacttcatt cgcattttac ctggagacaa agttacggta gaattatctc catatgactt 147361 aactcgtggc aggattacgt accgttacaa ataaagcact ccggaaactg aaggaggttg 147421 gaaacacatg aaagtgagac catcagttaa accaatctgc gaaaaatgta aagttattcg 147481 cagaaaagga aaagtaatgg tgatctgtga aaatccaaag cataaacaaa aacaaggata 147541 atttataagg aggtgcccag agaatggctc gtattgctgg tgtagatatc ccacgtgaca 147601 aacgtgttgt tatttcttta acatacatct tcggaattgg ccgcacaacg gctcagcaag 147661 ttttaaaaga agctggagtt tcagaagata ctcgtgtgcg cgatcttact gaagaagaac 147721 ttggtaaaat ccgtgatatt attgacaaac tgaaagtaga aggtgacctt cgccgtgaag 147781 tttctcttaa tatcaaacgt ctgatcgaaa tcggaagcta ccgcggaatc cgtcatcgca 147841 gaggattacc tgttcgcgga caaaactcta aaaacaacgc gcgtactcgt aaaggtccgc 147901 gtcgtactgt agctaacaag aaaaaataag taagggaggt tcttaaacaa tggctgctgc 147961 tcgtaaatct aacacgcgta aacgtcgcgt gaaaaagaat attgagtctg gaattgctca 148021 tattcgttca actttcaata acacgatcgt tacgatcact gacactcatg gtaatgctat 148081 ttcttggtct agtgccggag ctttaggatt cagaggttct cgtaaatcta ctccttttgc 148141 tgcgcaaatg gctgcagaaa cagctgctaa aggttcaatc gaacatggtc ttaaaactct 148201 agaggttact gttaaaggac ctggttcagg ccgtgaagct gcaatccgtg cacttcaagc 148261 tgctggacta gaagtcactg ctatcagaga cgtaactcct gttcctcata acggatgccg 148321 tccaccaaaa cgtcgccgcg tgtaatttgt ttgtatagat tttgtgtccc tgtcaataat 148381 gggttatgat acagttattt atgaaacgaa tgcaccgact cgttgcctga gcacatacgg 148441 gactaaacaa tggggaattt cggatggaat ctcatatgat tctattcgag gtttcgacgt 148501 tttgaaggag ggttttaagt aatgatcgag attgaaaaac caaaaatcga aacggttgaa 148561 atcagcgacg atgccaaatt tggtaagttt gtcgtagagc cacttgagcg tggatatggt 148621 acaactctgg gtaactcctt acgtcgtatc ctcttatcct cactccctgg tgccgctgta 148681 acatcaatcc agatagatgg tgtactgcac gaattctcga caattgaagg cgttgtggaa 148741 gatgttacaa cgattatctt acacattaaa aagcttgcat tgaaaatcta ctctgatgaa 148801 gagaagacgc tagaaattga tgtacagggt gaaggaactg taacggcagc tgatattaca 148861 cacgatagtg atgtagagat cttaaatcct gatcttcata tcgcgactct tggtgagaat 148921 gcgagtttcc gagttcgcct tactgctcaa agaggacgtg ggtatacgcc tgctgacgca 148981 aacaagagag acgatcagcc aatcggcgtg attccgatcg attctatcta tacgccagtt 149041 tctcgtgtat cttatcaggt agagaacact cgtgtaggcc aagttgcaaa ctatgataaa 149101 cttacacttg atgtttggac tgatggaagc actggaccga aagaagcaat tgcgcttggt 149161 tcaaagattt taactgaaca ccttaatata ttcgttggtt taactgacga agctcaacat 149221 gctgaaatca tggttgaaaa agaagaagat caaaaagaga aagttcttga aatgacaatt 149281 gaagaattgg atctttctgt tcgttcttac aactgcttaa agcgtgcggg tattaacacg 149341 gttcaagagc ttgcgaacaa gacggaagaa gatatgatga aagttcgaaa tctaggacgc 149401 aaatcacttg aagaagtgaa agcgaaacta gaagaacttg gactcggact tcgcaaagac 149461 gattgactag tttcccttgt gaactaggat tttcgtgtgt ttattattca gaaacagcat 149521 tccaataaag gaggggacat cacatgtcat acagaaaact aggacgtacg agtgcacagc 149581 gtaaagctat gcttcgtgat cttacaactg atttgatcat caacgaaaga atcgaaacaa 149641 ctgaaacacg tgcgaaagaa cttcgctctg tagttgaaaa aatgatcacg cttggcaaac 149701 gcggtgatct tcacgctcgc cgtcaagctg ctgcatacat ccgcaacgag gttgcaaacg 149761 aagaaaataa tcaagatgca cttcaaaaat tattctctga cattgcaact cgttacgagg 149821 agcgccaagg tggatacaca cgtattatga agcttggtcc tcgccgtggt gacggagcac 149881 caatggcaat tatcgaattg gtttaatcac atatttttgt gtatctaaag aagggcggga 149941 cagtttctaa ctggatctat gccctttttt tagatactgc aacttttaat agagagaaaa 150001 gcagagcatt agctgagagg aggccggttt tccatgaatc aaaatcagtt gatatcggta 150061 gaggatatcg tatttcgata tcggaaggac gcagaaagac gagcactaga cggcgtctcc 150121 ctgcaggtgt atgagggtga atggcttgca atcgtaggtc ataacggttc agggaaatca 150181 acactggccc gggcattgaa tggtttaatt cttcctgaat caggcgacat tgaggttgcc 150241 gggattcaat tgacagagga atctgtttgg gaagtgcgta agaagatagg tatggtcttt 150301 caaaatccgg ataaccaatt tgtcggaacg actgttcgcg atgatgtggc ttttggttta 150361 gaaaacaatg gtgtaccgcg ggaagaaatg attgagagag tagactgggc agtaaaacag 150421 gtgaatatgc aagattttct cgatcaagag ccgcaccatc tctccggagg ccaaaagcag 150481 agagttgcga ttgcgggggt tattgccgca cgtcctgata ttattatctt agatgaagca 150541 acatccatgc ttgatccgat cgggcgagaa gaagtgcttg aaacggtaag acatttaaaa 150601 gagcagggca tggcgactgt catatccatt acacatgacc tgaatgaggc agcaaaagca 150661 gacaggatca ttgtcatgaa tggcggtaaa aaatatgctg aagggccgcc tgaagagatt 150721 tttaaattga ataaagaact tgttcgaatt gggcttgatt tacccttctc attccagctt 150781 agccagcttt taagagaaaa tggactggct ttggaagaaa accatttgac tcaggaaggg 150841 ctggtgaaag agctgtggac attacaatca aagatgtaga gcatcgctat cagatgaaga 150901 ccccgtttga gcgcctagca ctgtatgata tcaatgcatc gattaaagaa ggaagctacg 150961 tagccgttat cgggcataca ggctctggca agtccactct tctacagcac ctaaatggtc 151021 tcctgaagcc gacgaaggga cagatatcac taggcagcac tgtcattcag gcagggaaaa 151081 agaataaaga tctgaaaaaa cttcgtaaaa aagtcggaat cgttttccaa tttcctgagc 151141 atcaattatt cgaagaaaca gttcttaaag atatttcatt cggaccgatg aactttggtg 151201 ttaaaaaaga agatgctgaa caaaaagcga gagagatgct gcagcttgta ggtttatcag 151261 aagagctttt ggacaggtca ccctttgaat taagcggggg acaaatgcgc agagttgcaa 151321 ttgccggcgt acttgcaatg gaccctgaag tgcttgttct ggatgaaccg actgcaggat 151381 tggacccaag agggcgaaaa gagattatgg acatgtttta tgagcttcat caacgtggga 151441 acttgacgac gatccttgtg acacacagca tggaggatgc agctgcatac gctgatgaaa 151501 tgattgttat gcataaagga acgatacaag catcaggcag tccgcgtgat ctgtttttaa 151561 agggtgaaga gatggccggc tgggggctgg atcttcctga aacaataaaa ttccaaagac 151621 accttgaagc tgcactgggt gtgagattta atgagcctat gctcacaatc gaagatgccg 151681 ctgccgaaat ccgtgctctt tttcagggag agaagacttt atgatggaca gcatgattat 151741 cggcaagtat gtaccgggga cttcacttgt gcaccggctt gaccccagaa caaaactgat 151801 cacgatcttt ttatttgtct gcattgtatt cttagccaat aatgttcaga catatgcgtt 151861 gcttggttta tttacaattg gcgtcgtttc tttaacaaga gttcctttct cttttttaat 151921 gaaagggctg aagccaatca tctggattgt cctttttacg ttccttcttc acattcttat 151981 gacacatgaa ggaccgatta tctttcaaat aggttttttc aaagtctatg agggcggtct 152041 ggttcagggg atattcattt ctcttagatt cgtctatttg attttaatca caaccttatt 152101 aacgcttacg actacaccga ttgagattac cgatggaatg gagcagctgc tgaacccatt 152161 gaaaaaatta aagcttcctg ttcatgagct ggctcttatg atgtcaattt ctttacggtt 152221 tattccgaca ctgatggagg agacagataa gatcatgaag gctcagatgg cgcgaggcgt 152281 tgattttaca agcgggcctg tcaaagaaag agtgaaggct attgtcccgc ttcttgtccc 152341 gctcttcgtc agcgcattta aacgcgccga agagcttgcg gtggcaatgg aagcaagagg 152401 ctatcaaggc ggagaaggac gtacgaaata tagaaagctt gtatggacag gaaaagacac 152461 ttctgtcatt gtcagcttaa ttgtattagc tgctttgtta tttttcttaa gggcttagag 152521 gtgctgtatg agactgaaat gcacgatttc ttatgacgga catttgttta acggttatca 152581 ggttcagccg ggcaaaagaa cggttcagga tgaactggag aaggctttgg ctgtcctgca 152641 taagtcaaaa gacagaattc cggtcgtttc gtctggaaga acagacagcg gggttcacgc 152701 agccggacag gtgattcatt ttgacactcc gctgtctatc ccggctgaga gatggccata 152761 tgccttaaat gcactgcttc cggacgatat cgcagtcaaa caggcagaaa ttgcggatga 152821 tgggttccat gcacgattta gcgcagtcaa aaaagaatat cgctactttg tatacacgga 152881 gaaacacccg gacgtattta aacggcatta cgcttaccat ttttcatatc gccttaatgt 152941 gcaggacatg agagaagcgg caaagcatct tatagggaca catgatttta cgagcttttg 153001 cgcggctaaa acagaagtgc aggacaaggt aagaacgata tacgaacttg attggactga 153061 gacggctgac ggcctgcaaa tgcggatcac aggcagcggt ttcttatata atatggtcag 153121 aattattgcg ggtactttgc ttgatgcagg tattggaaaa atttctcccg atgaggtgaa 153181 atccatgctg gaagcgaagg atcgcgaagc ggcagggcgc acagcgccgg ggcacgggct 153241 atatttatgg aacgtttact atgacaacta aaccaggtgt ataatatttt cttgacagag 153301 tctgcataaa gttataagat atcatatggt atgtatttca accccacgat aagccccgga 153361 acttattgtg ttgtgaaata gaacgtaatc gaagtttatt gaaaatgaca gatcatttag 153421 gagggaaatt caatgcgtac aacacctatg gctaacgcaa gtactattga acgcaagtgg 153481 ttagttgttg atgctgctgg caagacttta ggtcgtcttt cttcagaagt tgcagctatc 153541 cttcgcggaa aacacaaacc aacttacaca ccacacgttg atactggaga tcatgtgatc 153601 atcatcaacg ctgaaaaaat cgagttaact ggtaaaaagt taactgacaa aatctactac 153661 cgtcacactc aacatccagg cggattaaaa tcaagaactg ctcttgaaat gcgtacaaac 153721 taccctgaga aaatgcttga gcttgctatc aaaggcatgc ttccaaaagg ttctctaggt 153781 cgtcaaatgt tcaaaaaatt gaacgtatac cgtggttctg agcatccaca cgaagcacaa 153841 aaacctgaag tttacgaact tcgcggttaa ttaaaaagga ggttaccaat ttggcacagg 153901 ttcaatatta cggtactggc cgtcgtaaaa gctctgtagc gcgtgtgcgt ttagttccag 153961 gagaaggccg tatcgtcgtt aataatcgtg aaatcagcga acatatccca tctgcagctt 154021 taatcgaaga tatcaaacaa ccattaactt tgactgaaac agctggcact tatgatgttt 154081 tagtaaacgt acatggaggc ggcctatctg gtcaagctgg agcaatccgt cacggtatcg 154141 ctcgtgcttt gcttgaagca gatccagaat accgtacaac tcttaaacgt gcaggtcttc 154201 tgactcgtga cgctcgtatg aaagaacgta aaaaatacgg tcttaaaggc gctcgtcgtg 154261 cacctcagtt ctcaaaacgt taattttacg ttttcaaaaa gctctcgacc ttgggttggg 154321 agcttttttc tttcaataaa acgtggcagt cccgcataaa aataacaact gaatggacgc 154381 ttgacggggt taagcaaatt gtttgtttat aaacggtctc tttgtaataa tcatggtaga 154441 tttcattctt attcaattgg aagttcggtc aatgtttatt atcgttatgt gatcagccca 154501 gctccatcta accactgtat ctcatccgtt aaagttcact gctgattctt aacccggaga 154561 aacaatagct ctcattgcta atggctttat gtaacgaagt aaaagtaaat ctgatgatat 154621 aaatcacata tctcctttgt gatttttttg cgtttttatg aacttttttc taaatatgca 154681 aagggaaagc gatatcaatc tagaaatatt tgttatactc tatacattaa agtaaggaga 154741 agattcatga atgcgttagt agctcataat agcaaagcct gggataaaaa agtagaaaca 154801 ggcaatgaat ggactgttgc tgttgaacag caggttatcg aacaagcaaa aaaaggcaat 154861 tgggatataa gggtaacacc aatgaaagat gtaccgaagg attggtttcc gcctatcaaa 154921 ggtctgaaag tactctgttt agcatcaggc ggcggccagc agggtccagt tttggcagcc 154981 gcaggcgcgg atgtcactgt attagataac tcagaaaaac agctgaatca ggatagaatg 155041 attgctgagc gagatggtct gacgatacac actgtcaaag gaagcatgga cgatttaagt 155101 gtatttaatg atgaatcatt tgatgtcatt gtacatcctg ttgccaatgt ttttgttgag 155161 aatgtcctcc cggtatggaa ggaagcgtac cgtgtgttga aaaggaacgg cattctaatc 155221 tcgggttttg tcaatcctgt tgtatttctg tttgatacag aattagaaca gcaaggtgtt 155281 ttaaaagtaa aacactctat tccatacgct gacccagaag atcttccgaa acataaagtg 155341 aaaaaactga tcgaaaataa tgaggctctg gaattcggcc attccttaga agaccaaatc 155401 aaaggccaaa ttgatgccgg ttttatcgtt actggttttt atgaagataa aggcggtttt 155461 gtattagacc aatatatcca tacatattct gcaacaagaa gcgtgaaagt atgaaaagca 155521 gcgacctgtt agaggggctg cttttttcat aaccaattac agaacatttg ttcctcaccc 155581 tgcagaaagc tgatttttta tcaatgttac accttcattt gggcgaattt ccaaccgaat 155641 tcgggcattg tttcatcatc caaacctcaa aataatcggt aaaaggagag tgaatttata 155701 tggcagaagt actgtctttt atggatgtga aacgccaaaa ggattttgaa ttagaaaaga 155761 acttgctcaa agaactctct ctgagacaaa ttatccagtc tgttaaggat tgtttggaac 155821 cattatttcc atttttacat gatgaacgag atattattac cgaaggctgt attgattttg 155881 cgattgaagc ttatttgtta ggcgggcgtt ttgggatatt cggctattac ggagaatcaa 155941 tgcagagtat cagtgcccgc tctgcaagag aagaagaaga gctgcgtatg gagttttttg 156001 attatctcta taattggata cacgagcaat acgcaacatt tgataaaaac actgtttatg 156061 aagcggcacg caagttcatt aaagattggt ggacagcagg gtttgttcaa agagaaaaac 156121 agtgtaagct tcgcatgcgg taatcatatt tcccgaccct gtcccatagt tatgtaataa 156181 cggacaagcg ggaggggaag ggatgaggaa aaagcttaaa tggctcagtt ttttgctagg 156241 cttcatcata ttactatttc tgttcaagta tcagttcagc aataacgact cttggaagcc 156301 gtggagcctg cccttgagcg gtaaaatcat ttatctagat ccaggtcatg gcgggcctga 156361 cggcggagca gtcggcggaa agctgttaga gaaggatgtt accctggaag tggcctttag 156421 agtcagggat tatcttcaag aacaaggagc gcttgttatc atgaccagag aaagtgatac 156481 tgatctcgct ccagaaggaa caaaaggcta tagccgacga aaagctgagg atctaagaca 156541 acgagtcaaa ttaataaacc attcagaggc ggagctctat atcagcattc atcttaatgc 156601 gattccgtca caaaaatgga gcggagccca aagcttttat tacgggaaat atgcggaaaa 156661 tgagaaagtc gcaaaataca ttcaggatga gctgagaaga aatctggaaa acacaacccg 156721 gaaagcaaag cggattcatg gtatctactt aatgcaaaac gtcaccaaac cgggggcgct 156781 tatagaagtc ggatttttat ccaatccaag tgaagcaacg ttgctcggta aaccgaaata 156841 tcaagacaag gtggcatctt ccatatataa aggcattttg cgatatttca cagaaaaagg 156901 agaccctccg gagtaatgga gggttttctt gtggttctaa gcataagaca cccgccattt 156961 atgtatgata taataataat tgtaaacgaa tacacaaaag ggtgaggttc gatgataaga 157021 gaagatgaag taagaaaact agtcggagaa atgcgcgaac cttttcttca aagacctctg 157081 ggagaattgg atgccgttaa ggaaattaaa ataaagcctg aaaaacggca tatcagtgta 157141 aaagtcgctc ttgcaaaaac aggaactgca gaacaaatgc agattcagca agagatcgta 157201 aacgtattaa aaggggcagg agctgagaca gtcggccttc gatttgaaga gctgcctgaa 157261 gaaacggttg ctaaattccg ggcgccgtca gctgagaaaa aaacattatt aaatatggat 157321 aacccgccag tctttcttgc tgtagcaagt ggaaaaggcg gcgtaggcaa gtcaactgtg 157381 tcagtaaacc tagctatttc tctggctcgt ctagggaaaa aggttggttt aattgatgcg 157441 gatatttatg ggttcagtgt gccggacatg atgggtatca ctgtgcgtcc aacaattgaa 157501 ggagagaaac ttcttcctgt tgaacgcttt ggagtaaagg tcatgtcaat gggctttttc 157561 gtagaagaaa atgccccggt cgtatggaga gggccgatgc tcggcaaaat gctgaataat 157621 tttttccatg aagtagagtg gggagaagta gactatatcg ttcttgatct tccgcctggt 157681 acaggggacg ttgctctcga tgtacataca atgcttccga gctgcaaaga aattatcgta 157741 tctacgccac atccgacagc tgcttttgtc gcggccagag cgggctctat ggcgattaaa 157801 accgatcatg aggtcgtggg tgtcatagag aacatggctt attatgaaag tgcaaagaca 157861 ggggaaagag aatatgtgtt tggaaaaggc ggaggagata aactggctga ggaactaaac 157921 gtgcctttgc tcggcagaat cccattgaaa cagcccgatt gggataagga ccaatttgct 157981 ccgtctgttt atgacgaaaa tcatccaatc ggagaaatat atcaggacat cgcaaaaaaa 158041 atagatgcaa aaatgtcagt gcaggtataa aaggtgaacc gggattccag atcccggctt 158101 tccctttatt cactttcttt tgctgtgtct tttgctgctt ttttcagctc atcttcgaac 158161 tgctttttgt aaagcggact agaaagtgtt tcgttaataa cctcttctaa ataactgcgg 158221 aattcttggc tttttgccag ctggctgtac tttttatcca tgccgggatc ctgcataacg 158281 ctcatcagca tcttctggta atctggatcc ttcatcagct ttttaatcac tttttcatgc 158341 tctgtctgaa gagttttggc aaagccctca gcaaaatcag tgtcttcaaa gatgtttttc 158401 caaaattctt cacctttttt agatgtgagt gttttttcta ttgttccttt aattgcatct 158461 tggtcaatca ccagcgcttc attcatggca tcatcattta ataattcctt aatagctttc 158521 tttccatcat cagtttttaa tatatcaaca accatttttt tggtctgatc atagtccata 158581 tccgctgctt ggtcttttgg agcgcaagct gttacagata ataacaaaaa acagctcatc 158641 aatagcgttt tggcttttga catgcttaag ctcctttcac atacttgtct tacctttaat 158701 atgattcatc tgtttggaat tatacataac aaaatatcgc tgttcgcgat ttttgagggg 158761 atgaataaag aaatgaaaag ccgtggttta gttcgttttt tcttttctat tttagctgtc 158821 ggggcgctta tcacgagtat tgtgggtttt gctttaaagt ggggagaata tagagggctg 158881 tttctaacat ttgaagcggg acagattttc tctgttttat tttggtttat cggtgtaggc 158941 atgattttca gtgtgatcag ccaaatgggt tttttcgtgt ttttaacagt tcatcggttt 159001 gcgcttgaga tattaaggtc ctcctctttg tggaatttgc tgcagttgtt tttcatcctg 159061 tttgttgctt ttgatttaat gtacgtgcgt tttttatttt ttggagagag cggagaatcg 159121 ctggctggct atgcgtggtt accggtgttt ttattgatct ttggagtgat tacagcttat 159181 ataaagcaaa agcagtcctc taagaaaaca tttgtgtcat cgttattttt gatggttgtg 159241 attaccgcat tagaatggtt ccctgcatta agagtaaatg atgaggactg gctttattta 159301 atgctttttc cgttaatggc atgtaatgcc ttccaattgc tgatgctgcc gaagtttgca 159361 gcaaagtaat tactttacct ctgcggattt ggcatcagaa tttgcgatga gatcacccac 159421 ggttacattt tttaatcctt tttctttcag ctgatggatg atatcaggca atgcttcttc 159481 tgtttgtttt gcagaatcgg aggcatgtaa aagaataatg tctccaccgg aaacttgctt 159541 ggtcacattg tcgatgattt tttcaactcc gggatttgtc cagtcttgag agttcacact 159601 gtaatgaacg actgtataat tgtattgctt tgcgaccttt agaacattct tattgaattg 159661 gccggtaggg ggtcttaata gctgtatgtc tttgacccct aacttttcaa aggctgtttg 159721 cgcacggttc atgtcctttt ttatttcgct gctctctaaa ttggcatagt ttttataagc 159781 gtagcccatg ctcccgattt gatggccgtc ctttacgata cgggccactg tgtcgggatg 159841 gcgttctgcc caagaagcgg acaggaaaaa cgttgcgttt ttaatcccgt ttgctttcag 159901 agtattaagt atcggttctg ctctctcatc accccagctg atatcgaaag taagtgaaat 159961 atctttagag tctgtttctc ctttataaat ggctttaggt ccggtgtcag ttgaaaacac 160021 gggaagcggg acagctcttt ggatataaaa aaagctggca gctgcaaatg cggcgataag 160081 tataataatt aattgtttta cccgtttaat gtgccacaca tagaagtgat tcactgatga 160141 tgcctcctta tcttgtccat cattcttgtt ttacatctta tgagcatgga caattgaata 160201 taaccgataa aatgtctctt cacatacagc ctaaattggg tgttgacctt ttgataatat 160261 ccgtgatata ttattattcg tcgctgataa acagctgaca tcaactaaaa gcttcattaa 160321 atactttgaa aaaagttgtt gacttaaaag aagctaaatg ttatagtaat aaagctgctt 160381 cgttaagcgg cagtaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca 160441 tttttataaa tcgcacagcg atgtgcgtag tcagtcaaac tactttatcg gagagtttga 160501 tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag cggacagatg 160561 ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta acctgcctgt 160621 aagactggga taactccggg aaaccggggc taataccgga tggttgtttg aaccgcatgg 160681 ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc gcattagcta 160741 gttggtgagg taatggctca ccaaggcaac gatgcgtagc cgacctgaga gggtgatcgg 160801 ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag ggaatcttcc 160861 gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt tcggatcgta 160921 aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct tgacggtacc 160981 taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta ggtggcaagc 161041 gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc tgatgtgaaa 161101 gcccccggct caaccgggga gggtcattgg aaactgggga acttgagtgc agaagaggag 161161 agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac cagtggcgaa 161221 ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc gaacaggatt 161281 agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg gtttccgccc 161341 cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg caagactgaa 161401 actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta attcgaagca 161461 acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata ggacgtcccc 161521 ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg 161581 gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag ttgggcactc 161641 taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat catcatgccc 161701 cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc gaaaccgcga 161761 ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa ctcgactgcg 161821 tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg ttcccgggcc 161881 ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg tgaggtaacc 161941 ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt aacaaggtag 162001 ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg gaatataaga 162061 ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga tcattccttc 162121 gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaagtaa tacaagatat 162181 cacatagtga ttctttttaa cggttaagtt agaaagggcg cacggtggat gccttggcac 162241 taggagccga tgaaggacgg gacgaacacc gatatgcttc ggggagctgt aagcaagctt 162301 tgatccggag atttccgaat ggggaaaccc accactcgta atggagtggt atccatatct 162361 gaattcatag gatatgagaa ggcagacccg gggaactgaa acatctaagt acccggagga 162421 agagaaagca aatgcgattc cctgagtagc ggcgagcgaa acgggattag cccaaaccaa 162481 gaggcttgcc tcttggggtt gtaggacact ctgtacggag ttacaaagga acgaggtaga 162541 tgaagaggtc tggaaaggcc cgccatagga ggtaacagcc ctgtagtcaa aacttcgttc 162601 tctcctgagt ggatcctgag tacggcggaa cacgtgaaat tccgtcggaa tccgggagga 162661 ccatctccca aggctaaata ctccctagtg accgatagtg aaccagtacc gtgagggaaa 162721 ggtgaaaagc accccggaag gggagtgaaa gagatcctga aaccgtgtgc ctacaagtag 162781 tcagagcccg ttaacgggtg atggcgtgcc ttttgtagaa tgaaccggcg agttacgatc 162841 tcgtgcaagg ttaagcagaa gatgcggagc cgcagcgaaa gcgagtctga atagggcgca 162901 tgagtacgtg gtcgtagacc cgaaaccagg tgatctaccc atgtccaggg tgaagttcag 162961 gtaacactga atggaggccc gaacccacgc acgttgaaaa gtgcggggat gaggtgtggg 163021 taggggtgaa atgccaatcg aacctggaga tagctggttc tctccgaaat agctttaggg 163081 ctagcctcaa ggtaagagtc ttggaggtag agcactgatt ggactagggg cccctaccgg 163141 gttaccgaat tcagtcaaac tccgaatgcc aatgacttat ccttgggagt cagactgcga 163201 gtgataagat ccgtagtcga aagggaaaca gcccagaccg ccagctaagg tcccaaagta 163261 tacgttaagt ggaaaaggat gtggagttgc ttagacaacc aggatgttgg cttagaagca 163321 gccaccattt aaagagtgcg taatagctca ctggtcgagt gactctgcgc cgaaaatgta 163381 ccggggctaa acgtatcacc gaagctgcgg actgttcttc gaacagtggt aggagagcgt 163441 tctaagggct gtgaagccag accggaagga ctggtggagc gcttagaagt gagaatgccg 163501 gtatgagtag cgaaagaggg gtgagaatcc cctccaccga atgcctaagg tttcctgagg 163561 aaggctcgtc cgctcagggt tagtcgggac ctaagccgag gccgaaaggc gtaggcgatg 163621 gacaacaggt tgatattcct gtaccacctc ctcaccattt gagcaatggg gggacgcagg 163681 aggatagggt aagcgcggta ttggatatcc gcgtccaagc agttaggctg ggaaataggc 163741 aaatccgttt cccataaggc tgagctgtga tggcgagcga aatatagtag cgaagttcct 163801 gattccacac tgccaagaaa agcctctagc gaggtgagag gtgcccgtac cgcaaaccga 163861 cacaggtagg cgaggagaga atcctaaggt gatcgagaga actctcgtta aggaactcgg 163921 caaaatgacc ccgtaacttc gggagaaggg gtgctctgtt agggtgcaag cccgagagag 163981 ccgcagtgaa taggcccagg cgactgttta gcaaaaacac aggtctctgc gaagccgtaa 164041 ggcgaagtat aggggctgac gcctgcccgg tgctggaagg ttaagaggag cgcttagcgt 164101 aagcgaaggt gcgaattgaa gccccagtaa acggcggccg taactataac ggtcctaagg 164161 tagcgaaatt ccttgtcggg taagttccga cccgcacgaa aggcgcaacg atctgggcac 164221 tgtctcaacg agagactcgg tgaaattata gtacctgtga agatgcaggt tacccgcgac 164281 aggacggaaa gaccccgtgg agctttactg cagcctgata ttgaatgttg gtacagcttg 164341 tacaggatag gtaggagcct tggaaaccgg agcgccagct tcggtggagg catcggtggg 164401 atactaccct ggctgtattg accttctaac ccgccgccct tatcgggcgg ggagacagtg 164461 tcaggtgggc agtttgactg gggcggtcgc ctcctaaaag gtaacggagg cgcccaaagg 164521 ttccctcaga atggttggaa atcattcgca gagtgtaaag gcacaaggga gcttgactgc 164581 gagacctaca agtcgagcag ggacgaaagt cgggcttagt gatccggtgg ttccgcatgg 164641 aagggccatc gctcaacgga taaaagctac cccggggata acaggcttat ctcccccaag 164701 agtccacatc gacggggagg tttggcacct cgatgtcggc tcatcgcatc ctggggctgt 164761 agtcggtccc aagggttggg ctgttcgccc attaaagcgg tacgcgagct gggttcagaa 164821 cgtcgtgaga cagttcggtc cctatccgtc gcgggcgcag gaaatttgag aggagctgtc 164881 cttagtacga gaggaccggg atggacgcac cgctggtgta ccagttgttc tgccaagggc 164941 atcgctgggt agctatgtgc ggacgggata agtgctgaaa gcatctaagc atgaagcccc 165001 cctcaagatg agatttccca ttccgcaagg aagtaagatc cctgaaagat gatcaggttg 165061 ataggtctga ggtggaagtg tggcgacaca tggagctgac agatactaat cgatcgagga 165121 cttaaccata tttttgaatg atgtcacatc tgttatctag ttttgagaga acactctcaa 165181 tttgtttggt ggcgatagcg aagaggtcac acccgttccc ataccgaaca cggaagttaa 165241 gctcttcagc gccgatggta gtcgggggtt tccccctgtg agagtaggac gccgccaagc 165301 agatttatta attctaccat gtttgtttat gaagctttat attattccgc agtagctcag 165361 tggtagagct atcggctgtt aaccgatcgg tcgtaggttc gaatcctacc tgcggagcca 165421 ttgcttccat agctcagcag gtagagcact tccatggtaa ggaagaggtc agcggttcga 165481 gcccgcttgg aagcttaaat gtattattac caaggtttct cataaggaga aagctttttt 165541 tattgcgata tgcggaagta gttcagtggt agaacaccac cttgccaagg tgggggtcgc 165601 gggttcgaat cccgtcttcc gctccattta tcctaacggg atattgtaaa ttgaattgcg 165661 cccgtagctc aattggatag agcgtttgac tacggatcaa aaggttaggg gttcgactcc 165721 tctcgggcgc gccatatctt ttaatagaat agataggaaa tcgggaagta gctcagcttg 165781 gtagagcaca tggtttggga ccatggggtc gcaggttcga atcctgtctt cccgaccatt 165841 ttttatgggg ccttagctca gctgggagag cgcctgcttt gcacgcagga ggtcagcggt 165901 tcgatcccgc taggctccac caaaagtttt taaaaaagtt attgactttg aagaagtgac 165961 attgtatact aataaagttg ctttaacaaa gcggacaaac aaaatgatct ttgaaaacta 166021 aacaagacaa aacgtacctg ttaattcagt ttttaaaaat cgcacagcga tgtgcgtagt 166081 cagtcaaact actttatcgg agagtttgat cctggctcag gacgaacgct ggcggcgtgc 166141 ctaatacatg caagtcgagc ggacagatgg gagcttgctc cctgatgtta gcggcggacg 166201 ggtgagtaac acgtgggtaa cctgcctgta agactgggat aactccggga aaccggggct 166261 aataccggat ggttgtttga accgcatggt tcaaacataa aaggtggctt cggctaccac 166321 ttacagatgg acccgcggcg cattagctag ttggtgaggt aacggctcac caaggcaacg 166381 atgcgtagcc gacctgagag ggtgatcggc cacactggga ctgagacacg gcccagactc 166441 ctacgggagg cagcagtagg gaatcttccg caatggacga aagtctgacg gagcaacgcc 166501 gcgtgagtga tgaaggtttt cggatcgtaa agctctgttg ttagggaaga acaagtaccg 166561 ttcgaatagg gcggtacctt gacggtacct aaccagaaag ccacggctaa ctacgtgcca 166621 gcagccgcgg taatacgtag gtggcaagcg ttgtccggaa ttattgggcg taaagggctc 166681 gcaggcggtt tcttaagtct gatgtgaaag cccccggctc aaccggggag ggtcattgga 166741 aactggggaa cttgagtgca gaagaggaga gtggaattcc acgtgtagcg gtgaaatgcg 166801 tagagatgtg gaggaacacc agtggcgaag gcgactctct ggtctgtaac tgacgctgag 166861 gagcgaaagc gtggggagcg aacaggatta gataccctgg tagtccacgc cgtaaacgat 166921 gagtgctaag tgttaggggg tttccgcccc ttagtgctgc agctaacgca ttaagcactc 166981 cgcctgggga gtacggtcgc aagactgaaa ctcaaaggaa ttgacggggg cccgcacaag 167041 cggtggagca tgtggtttaa ttcgaagcaa cgcgaagaac cttaccaggt cttgacatcc 167101 tctgacaatc ctagagatag gacgtcccct tcgggggcag agtgacaggt ggtgcatggt 167161 tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc aacccttgat 167221 cttagttgcc agcattcagt tgggcactct aaggtgactg ccggtgacaa accggaggaa 167281 ggtggggatg acgtcaaatc atcatgcccc ttatgacctg ggctacacac gtgctacaat 167341 ggacagaaca aagggcagcg aaaccgcgag gttaagccaa tcccacaaat ctgttctcag 167401 ttcggatcgc agtctgcaac tcgactgcgt gaagctggaa tcgctagtaa tcgcggatca 167461 gcatgccgcg gtgaatacgt tcccgggcct tgtacacacc gcccgtcaca ccacgagagt 167521 ttgtaacacc cgaagtcggt gaggtaacct tttaggagcc agccgccgaa ggtgggacag 167581 atgattgggg tgaagtcgta acaaggtagc cgtatcggaa ggtgcggctg gatcacctcc 167641 tttctaagga tattatacgg aatataagac cttgggtctt ataaacagaa cgttccctgt 167701 cttgtttagt tttgaaggat cattccttcg aaacgtgttc tttgaaaact agataacagt 167761 agacatcaca ttcaagtaat acaagatatc acatagtgat tctttttaac ggttaagtta 167821 gaaagggcgc acggtggatg ccttggcact aggagccgat gaaggacggg acgaacaccg 167881 atatgcttcg gggagctgta agcaagcttt gatccggaga tttccgaatg gggaaaccca 167941 ccactcgtaa tggagtggta tccatatctg aattcatagg atatgagaag gcagacccgg 168001 ggaactgaaa catctaagta cccggaggaa gagaaagcaa atgcgattcc ctgagtagcg 168061 gcgagcgaaa cgggattagc ccaaaccaag aggcttgcct cttggggttg taggacactc 168121 tgtacggagt tacaaaggaa cgaggtagat gaagaggtct ggaaaggccc gccataggag 168181 gtaacagccc tgtagtcaaa acttcgttct ctcctgagtg gatcctgagt acggcggaac 168241 acgtgaaatt ccgtcggaat ccgggaggac catctcccaa ggctaaatac tccctagtga 168301 ccgatagtga accagtaccg tgagggaaag gtgaaaagca ccccggaagg ggagtgaaag 168361 agatcctgaa accgtgtgcc tacaagtagt cagagcccgt taacgggtga tggcgtgcct 168421 tttgtagaat gaaccggcga gttacgatct cgtgcaaggt taagcagaag atgcggagcc 168481 gcagcgaaag cgagtctgaa tagggcgcat gagtacgtgg tcgtagaccc gaaaccaggt 168541 gatctaccca tgtccagggt gaagttcagg taacactgaa tggaggcccg aacccacgca 168601 cgttgaaaag tgcggggatg aggtgtgggt aggggtgaaa tgccaatcga acctggagat 168661 agctggttct ctccgaaata gctttagggc tagcctcaag gtaagagtct tggaggtaga 168721 gcactgattg gactaggggc ccctaccggg ttaccgaatt cagtcaaact ccgaatgcca 168781 atgacttatc cttgggagtc agactgcgag tgataagatc cgtagtcgaa agggaaacag 168841 cccagaccgc cagctaaggt cccaaagtat acgttaagtg gaaaaggatg tggagttgct 168901 tagacaacca ggatgttggc ttagaagcag ccaccattta aagagtgcgt aatagctcac 168961 tggtcgagtg actctgcgcc gaaaatgtac cggggctaaa cgtatcaccg aagctgcgga 169021 ctgttcttcg aacagtggta ggagagcgtt ctaagggctg tgaagccaga ccggaaggac 169081 tggtggagcg cttagaagtg agaatgccgg tatgagtagc gaaagagggg tgagaatccc 169141 ctccaccgaa tgcctaaggt ttcctgagga aggctcgtcc gctcagggtt agtcgggacc 169201 taagccgagg ccgaaaggcg taggcgatgg acaacaggtt gatattcctg taccacctcc 169261 tcaccatttg agcaatgggg ggacgcagga ggatagggta agcgcggtat tggatatccg 169321 cgtccaagca gttaggctgg gaaataggca aatccgtttc ccataaggct gagctgtgat 169381 ggcgagcgaa atatagtagc gaagttcctg attccacact gccaagaaaa gcctctagcg 169441 aggtgagagg tgcccgtacc gcaaaccgac acaggtaggc gaggagagaa tcctaaggtg 169501 atcgagagaa ctctcgttaa ggaactcggc aaaatgaccc cgtaacttcg ggagaagggg 169561 tgctctgtta gggtgcaagc ccgagagagc cgcagtgaat aggcccaggc gactgtttag 169621 caaaaacaca ggtctctgcg aagccgtaag gcgaagtata ggggctgacg cctgcccggt 169681 gctggaaggt taagaggagc gcttagcgta agcgaaggtg cgaattgaag ccccagtaaa 169741 cggcggccgt aactataacg gtcctaaggt agcgaaattc cttgtcgggt aagttccgac 169801 ccgcacgaaa ggcgcaacga tctgggcact gtctcaacga gagactcggt gaaattatag 169861 tacctgtgaa gatgcaggtt acccgcgaca ggacggaaag accccgtgga gctttactgc 169921 agcctgatat tgaatgttgg tacagcttgt acaggatagg taggagcctt ggaaaccgga 169981 gcgccagctt cggtggaggc atcggtggga tactaccctg gctgtattga ccttctaacc 170041 cgccgccctt atcgggcggg gagacagtgt caggtgggca gtttgactgg ggcggtcgcc 170101 tcctaaaagg taacggaggc gcccaaaggt tccctcagaa tggttggaaa tcattcgcag 170161 agtgtaaagg cacaagggag cttgactgcg agacctacaa gtcgagcagg gacgaaagtc 170221 gggcttagtg atccggtggt tccgcatgga agggccatcg ctcaacggat aaaagctacc 170281 ccggggataa caggcttatc tcccccaaga gtccacatcg acggggaggt ttggcacctc 170341 gatgtcggct catcgcatcc tggggctgta gtcggtccca agggttgggc tgttcgccca 170401 ttaaagcggt acgcgagctg ggttcagaac gtcgtgagac agttcggtcc ctatccgtcg 170461 cgggcgcagg aaatttgaga ggagctgtcc ttagtacgag aggaccggga tggacgcacc 170521 gctggtgtac cagttgttct gccaagggca tcgctgggta gctatgtgcg gacgggataa 170581 gtgctgaaag catctaagca tgaagccccc ctcaagatga gatttcccat tccgcaagga 170641 agtaagatcc ctgaaagatg atcaggttga taggtctgag gtggaagtgt ggcgacacat 170701 ggagctgaca gatactaatc gatcgaggac ttaaccatat ttttgaatga tgtcacacct 170761 gttatctagt tttgagagaa cactctcaat ttgtttggtg gcgatagcga agaggtcaca 170821 cccgttccca taccgaacac ggaagttaag ctcttcagcg ccgatggtag tcgggggttt 170881 ccccctgtga gagtaggacg ccgccaagca attgcacatt agtgtaattt tttaaaaaag 170941 ttattgactt tgaagaagtg acattgtata ctaataaagt tgctttaaca aagcggacaa 171001 acaaaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca gtttttaaaa 171061 atcgcacagc gatgtgcgta gtcagtcaaa ctactttatc ggagagtttg atcctggctc 171121 aggacgaacg ctggcggcgt gcctaataca tgcaagtcga gcggacagat gggagcttgc 171181 tccctgatgt tagcggcgga cgggtgagta acacgtgggt aacctgcctg taagactggg 171241 ataactccgg gaaaccgggg ctaataccgg atggttgttt gaaccgcatg gttcaaacat 171301 aaaaggtggc ttcggctacc acttacagat ggacccgcgg cgcattagct agttggtgag 171361 gtaacggctc accaaggcaa cgatgcgtag ccgacctgag agggtgatcg gccacactgg 171421 gactgagaca cggcccagac tcctacggga ggcagcagta gggaatcttc cgcaatggac 171481 gaaagtctga cggagcaacg ccgcgtgagt gatgaaggtt ttcggatcgt aaagctctgt 171541 tgttagggaa gaacaagtac cgttcgaata gggcggtacc ttgacggtac ctaaccagaa 171601 agccacggct aactacgtgc cagcagccgc ggtaatacgt aggtggcaag cgttgtccgg 171661 aattattggg cgtaaagggc tcgcaggcgg tttcttaagt ctgatgtgaa agcccccggc 171721 tcaaccgggg agggtcattg gaaactgggg aacttgagtg cagaagagga gagtggaatt 171781 ccacgtgtag cggtgaaatg cgtagagatg tggaggaaca ccagtggcga aggcgactct 171841 ctggtctgta actgacgctg aggagcgaaa gcgtggggag cgaacaggat tagataccct 171901 ggtagtccac gccgtaaacg atgagtgcta agtgttaggg ggtttccgcc ccttagtgct 171961 gcagctaacg cattaagcac tccgcctggg gagtacggtc gcaagactga aactcaaagg 172021 aattgacggg ggcccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 172081 accttaccag gtcttgacat cctctgacaa tcctagagat aggacgtccc cttcgggggc 172141 agagtgacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 172201 cgcaacgagc gcaacccttg atcttagttg ccagcattca gttgggcact ctaaggtgac 172261 tgccggtgac aaaccggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgacc 172321 tgggctacac acgtgctaca atggacagaa caaagggcag cgaaaccgcg aggttaagcc 172381 aatcccacaa atctgttctc agttcggatc gcagtctgca actcgactgc gtgaagctgg 172441 aatcgctagt aatcgcggat cagcatgccg cggtgaatac gttcccgggc cttgtacaca 172501 ccgcccgtca caccacgaga gtttgtaaca cccgaagtcg gtgaggtaac cttttaggag 172561 ccagccgccg aaggtgggac agatgattgg ggtgaagtcg taacaaggta gccgtatcgg 172621 aaggtgcggc tggatcacct cctttctaag gatattatac ggaatataag accttgggtc 172681 ttataaacag aacgttccct gtcttgttta gttttgaagg atcattcctt cgaaacgtgt 172741 tctttgaaaa ctagataaca gtagacatca cattcaagta atacaagata tcacatagtg 172801 attcttttta acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg 172861 atgaaggacg ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga 172921 gatttccgaa tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata 172981 ggatatgaga aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc 173041 aaatgcgatt ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc 173101 ctcttggggt tgtaggacac tctgtacgga gttacaaagg aacgaggtag atgaagaggt 173161 ctggaaaggc ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag 173221 tggatcctga gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc 173281 aaggctaaat actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag 173341 caccccggaa ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc 173401 gttaacgggt gatggcgtgc cttttgtaga atgaaccggc gagttacgat ctcgtgcaag 173461 gttaagcaga agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt 173521 ggtcgtagac ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg 173581 aatggaggcc cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga 173641 aatgccaatc gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca 173701 aggtaagagt cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa 173761 ttcagtcaaa ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga 173821 tccgtagtcg aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag 173881 tggaaaagga tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt 173941 taaagagtgc gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta 174001 aacgtatcac cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc 174061 tgtgaagcca gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta 174121 gcgaaagagg ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt 174181 ccgctcaggg ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg 174241 ttgatattcc tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg 174301 taagcgcggt attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt 174361 tcccataagg ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca 174421 ctgccaagaa aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag 174481 gcgaggagag aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac 174541 cccgtaactt cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga 174601 ataggcccag gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta 174661 taggggctga cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg 174721 tgcgaattga agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat 174781 tccttgtcgg gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac 174841 gagagactcg gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa 174901 agaccccgtg gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata 174961 ggtaggagcc ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc 175021 tggctgtatt gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg 175081 cagtttgact ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag 175141 aatggttgga aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac 175201 aagtcgagca gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat 175261 cgctcaacgg ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat 175321 cgacggggag gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc 175381 caagggttgg gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag 175441 acagttcggt ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg 175501 agaggaccgg gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg 175561 tagctatgtg cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat 175621 gagatttccc attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg 175681 aggtggaagt gtggcgacac atggagctga cagatactaa tcgatcgagg acttaaccat 175741 atttttgaat gatgtcacac ctgttatcta gttttgagag aacactctca atttgtttgg 175801 tggcgatagc gaagaggtca cacccgttcc cataccgaac acggaagtta agctcttcag 175861 cgccgatggt agtcgggggt ttccccctgt gagagtagga cgccgccaag caagcttaaa 175921 cccagctcat tgagctgggt tttttgtttt atatctgtgc cgatttgctt tcgtcagtat 175981 ccattttatc aagcttctgc tttttaaagt tttctaatac ttttgaattc caatacaatc 176041 cctagcatga tcaacatgag agtcataaat aatcaaaatg cagtttgtac gggagactca 176101 tccagactcc atccgactgc gattggcagg atagagccgc caatccattg gcagcgaaca 176161 gcatgcttgt cgtttgttct gtttttccat gataaaattg attggtgaca ataaaataat 176221 ggcgaacatg ccggccataa ataagtccta agaaaaaact aagaataatc cctgcaaaag 176281 ctgttttatt gattgccaaa atacagagtt aaatgaggcc gctcatattt atcagcctga 176341 gataatgatg ataggttatt ttttcggaaa ccagctcggg ttgccaaatg agagaaaaga 176401 tattactgtc attaaaacga ttcttggttt catccggata tgataaaatg tctcagacta 176461 tatttgagcc atttttttct tcagcaatca tcttgcgtaa ttgataaaaa tttattatga 176521 tactctttgt atgacaactc cttgcctcaa tacaatatac tcaacgtttc cccgttttct 176581 ccggtcgttt ttcttttcat tttctcccgt aaaataaaaa aagctcccaa tacaatagat 176641 atggtgcgga tttatttttt actaaaaagg agtcgttata tttgaataat agttttacat 176701 taaaacagca atggttcggg aatatccgaa aagacattct tgctggcatt ttagttgcgt 176761 tagcgttaat acctgaagcg attggctttt ctattatagc cggtgtggat ccgatggtcg 176821 gtctttatgc gtcattttgc atagccatta ttatttctat ttttggtggc agacctggca 176881 tgatttcagc tgcgacaggc tcaatggcag tcgttatggt gtcgctggtt gctgatcatg 176941 ggcttcagta tttatttgcg gctacgattt tgacaggcat tattcaggtg attttaggta 177001 tcagtaaaat tgcaagatta atgaaattca tcccgcgttc tgtgatgatc gggtttgtga 177061 atgcgctggc gatccttatc ttctctgcgc agcttcccca gtttgaaggt gcttcttgga 177121 gcatgtatgc gatgcttgcc gggtcgttgg ttattattta tgtgctgcca aggtttacga 177181 ctgctgttcc gtctccgctt gtggcgatta ttgtgatgac aattattgcg gtcactttcc 177241 atgtggatgt gcggacggtt ggtgatatgg gcaatatttc tagttcattg cctcatttct 177301 taatccctga tgttccgttt acctttgaaa cactgcaaat tatttttcct tattcaattg 177361 ctttagcgtt tgtcgggttg cttgaatctt tgctgacagc acagattatt gatgaaatga 177421 cggatacgga tagtgataaa aataaagaga gccgcggaca gggaattgcg aatatcgtga 177481 ctggattctt tggcggaatg gcaggctgcg ctatgatcgg acaatctgtc attaatacaa 177541 aagcgggcgg tcgcggacgt ttgtcagcat ttgttgccgg tgcttttctg atgtttttaa 177601 ttgcggtgtt aagtcatgtc gtggtgaaaa tcccaatggc ggcgttagta gctgtaatgg 177661 ttatggtgtc tgtcggcact tttgattggt cttctttaaa aggtctcaaa aaagcgccgc 177721 tcacggactc gattgtcatg gttgtgactg tggttacggt tgttgtgacg gatgacttat 177781 ctaagggtgt atttgtcggt gttcttttaa gtgccgtgtt ctttgtagca aaaatctcga 177841 agctgaaaat cgtttctcat gcagaggatc aaaagcttag aacgtatcaa gtgaaggggc 177901 aaatcttttt tgcgtcagtg actgatctta cgaatgcgtt tatatatcaa gaggatattg 177961 agcgggttgt gattgactta actgaagctc acgtatggga cgattctggt gcggccgcac 178021 ttgataagat tgttgcgaag tttaaggaac aaggcattga agctgagtta aaaggtttga 178081 ataaagcgag taaatctcta atgaaacaga tggcataaaa tagagaagcc cagatgaatg 178141 agatctgggc ttttttatat aacatacact taagcagcat tgatataata gagagaagag 178201 aaattttaaa taggggactt gcatatgatg cttcagaagc tgaaccgtgt attggggaga 178261 gtgatgccgc tgttaacgcc gactagtgtg gtgctgggcg tgctgctgtc tcagttttta 178321 aatgggtatg aatgggctgt gccttggatc tttgctttta ttacgtttgc aggcagtttg 178381 agcgcgaact ttcaatcttt gagacatgca ttgtctcatc ctctccctat gattcttgca 178441 ctattcgttc ttcatatttt catgccgctt tttgcttggg gcagcggcca tcttatattt 178501 aaaggtgatc ctttgacgat taccggttta acattggctg ttgtgattcc tacggggatt 178561 acaagcttga tttgggcagc gatgtacaaa gggaatgtcg gtttgacact ttcgattatt 178621 ttagttgata ctgtgctgtc accgctaatc gtaccgctga gtctttcatt gctggccggc 178681 gctcaggttc acatggatgt gtggggaatg atgaaaggtc tgattgtaat ggtcgtgatt 178741 ccttcttttt tgggcatgct gtttaatcag atgtcatctc cagaaagaac tgcgtttgtg 178801 agcagtgcgc tgtcgccttt ttcaaagctt tgcttgatgg cagtgattgc gattaacagt 178861 tcagcgattg ctccttattt caaatccatt gatttgagat ttgcaggaat agctgtaacg 178921 gtattcttta tcgcgttaac aggttatgcc gctgcttggc tgatcggaaa aatgatgaaa 178981 aggcggcaag aggaaatagt ctctcttata tttacgggag gcatgaggaa tattagtgcc 179041 ggcgcagttc ttgccgttac gttcttcccg tctcaggttg ccgttcctgt tgtgatcggc 179101 atgctgtttc agcagatatt ggctgctttg tttggctata tgctgaatcg ttttgaatta 179161 aaaccaatgt tgcagaaggc ataaaaaaac cgctcatagg gttgagcggt tttttccgta 179221 tagccattcg agcgcgttga tgaactgttt gcagaaatac ttgtggtggt gcaccgctcc 179281 tttttcaatt gaaagacaca actggtcttc agtgaagcct ttttctttta gactttgatg 179341 aacttgcttt gtttttttca gcatatgtcg ctgaatggat tgtttttcac ggccttcttc 179401 actcccgata gacatgaaaa cacgtgcagt gccgggcttt aaagaagata tatgaatggt 179461 ttccgctgcg ttctcgtacc agtatgaacc tgatatagag cctattttcc cgaacattga 179521 cggatatttt aatatggcga acattgagat gaggccgcct aatgaggcac cgatcattcc 179581 tcttgactgc ggttccctgg tgacgttcca gttttcttcg attagcggaa tgaactggtt 179641 cgttatatca gacagatagt gatatcccat tccgccgaag tccgtgaacc gatcactgag 179701 tgatgcagcc ggccatgggg tgtattcatc aagccggttt tcgggttcga taccgatcag 179761 cacgagttca gggagccttt gctgttgaaa ggcgctttct agtaattcga tttggttttg 179821 gaacaaagaa ctgccatcct gcacgtaaac agcaggaaat cccccgctgt ctgtgctgta 179881 ggaaggaggg aggtacagcg tgaacctcct gttgccggct ttgtgttctg aaagagatcc 179941 tttcaagcat tctccccctt tttttgcttg aaaagcagat ataagaaata aggaactccg 180001 aggatcgcca aaatgatgcc tgcgggcact tctgcgggct gaaaaaacag ttttccggca 180061 aagtctgcgc ttatcacaag aagcatcccg attaaaccgc tcagtggcag gatatagcga 180121 tgttcgacgc cagccagtct ccgtgagata tggggagcaa ttaagccgac aaacgccata 180181 cttcccgcta cggagacaca ggcgctgatg attgctacac aggcaacgag aaggatggtt 180241 ttttctttat ttgatgaaat accgaggctt ctgactgtgt cttcatcaaa acgaatggtg 180301 tcgagcaggc gggatttgcc gataagaatc ggtataaaca gcagcatcca tgggagtaca 180361 gctgtaatat acgtccagtt ggcagaccag atgcttccgt ttttccacac catggccatt 180421 tgatagtctt gcgggtccat ttttaaagat aaaaacaaag acagggcgct gaatcctgaa 180481 ttgatcgcaa tccctaccaa aataattctt cctgaatcta aattgcctct gtgccatgca 180541 aatatgtaaa tcaggatcgc cgcgatgagc ccgcctatca atccaaagag cggcattccc 180601 atcgctgcag ctatggatgt cacttccttc tggccttgga ataagagcat aaacgctaca 180661 atgccagctc ctgcccctgc gttgattccg agaattccag ggtcagcaag cccgtttctc 180721 gtgatggcct ggataacagc gcctgcaatg ccaagaccga gtccaataat agcagccatg 180781 acaacccgcg gcagtcttaa atcgaacagc aaaatttcat actgcggatt cgggtcgatt 180841 tgaaaaagag tggagagcag ctcagcagga cgaacagaaa atgatccgct cgttaagctg 180901 aaatagctga caacaagaat caaagcgatg aacaatgcat attttttagc cattttgctc 180961 ccctcctttt cgtttaatta aataaaggaa gaaaggtacg ccgataatgg atgttacgac 181021 ctcaatcggt gtttcaaacg gatagttgat aaatctgctt gcgagatcac acagggttaa 181081 aaagattccg cccaaaatac aggaacacgg aatcagcctg ctgtaatcag agccgacgag 181141 aaatctcgtg atatgcggaa caaccaaccc gacaaacgca atttttccgg ccagcgctac 181201 ggcactgccg gttagaatga tgacggaaag catcgccatg attttaatgg tttttttctt 181261 ttgccccagg cttttagaaa tgtcgtcccc taatgataca gcggttacct ttttgctgag 181321 agaaatggcc attataatgc caatcaggaa aaacggagcg gcaagcttca ggaaatctgg 181381 actcatttga tgaagtctgg cactgtacca gaaactgaga tcctgagaaa tttgaaaata 181441 aatcgacatg gccgctgata agctgctgag cagcatgctt gtgactgtgc cgatgatggc 181501 gagctgcacg ggggtaaatc cgtttggcat catggcggca aggccgaata ctaacaccgc 181561 tcctaacgct gagccgataa aagagtatat catcatttca atcgaagatg attgcgggag 181621 cagaaccatg caaagcgtaa tgataaacgc tgaaccatct gaaacaccca taatggatgg 181681 cgaagctaaa taattgcgcg taatgccctg cataagcgct ccagaaacag caagggctgc 181741 ccctatgagc agagcgccgg cagcccttgg aatccgggaa tgccatataa tttgatggtc 181801 tgtgtttccc ggatcgaaat gaataagaga tgtaaaaaca atatctgtgc tgagatgctt 181861 tgccccataa aggattgaaa gcaaaagtga cagcgctata gcaaatggag aagtaatcaa 181921 tatgatacgt gtccactgtt ttgaatacat acaaaaacct actctgaatt agttttgtgt 181981 caatttttca gcagccgctt tcaggaaacg gactttgctc caagctgtgc cgccttgtgc 182041 gagagggtcc actgagttga catacacatg gtcttctttg actgctttaa ggcttttcca 182101 gattggattt ttctctaaat cttttaaggc atcaggtttg tctgcatttt catcatcaga 182161 aaattggacg aaaatatggt ccgggttcat ttcacttaat ttttctaatg aactcagctc 182221 ttgcgctttt gcagccttta cttcgttcgg cgccttaagg cctaaatcac cgtatagtgt 182281 ggagttgaaa tacacctgtt cagggtaaat gtaaatgttg ccttgtctga ttctgatgac 182341 aagcgctttt gaatctttcg ctttatcgtt gatttttgtt tttatttctt ttagatcctg 182401 ttcatagtct gcaataattt tctttgcttt tttctctttt ccagtcagct gggcaagaag 182461 catcatgttt tccttccagt ttgaagagat atgagaaact gggatcgtcg tgcctgctgt 182521 gctgattttt tgcagcgttt tttccggaaa ctttgttgaa gcaaggataa catctggctt 182581 catttcaaga atcttttcaa tatttggctc cattttttct ccggttggtt cggctttatc 182641 agtgatgtct ttgaacatat cagggaattt gccggagaat gaaattgcgc cttgcggatg 182701 aacgtcaagc aatttcgcgt cttccattga ttcaacgctt cccgtaatgg caattttgtc 182761 tgtcggtaca gttacttcat atgttttatc aaggtattca attttcttct tctcagatgc 182821 tgtgccgctt gccttgctgg cagttgattc atttttgctg ccgcaagctg ccgccgtcag 182881 cgcgagaagt aagattaata aggtaagaga tatctttttc atctatagag cctcctgttc 182941 aattgataac tattatcaat tggaattata gagaatgaac agatataaca ccatggacaa 183001 attcctgatt tatcatggac aatctccgga tagtaaagaa acagtttgct gaacgatgcg 183061 ttcgtgcccg caagctgagt attcattcca cgggtcaagg gatagaagat aaacacggtt 183121 atctcgtacc gcgcttaggt tttgccatgc ttctgtctgc tgtaattgct ggtagtaagc 183181 tatggtctcc ggctctttaa aaagaaaaag catcatacag tcagcttggt aatttgcgat 183241 attttctaac gaaatcgctt gttctgaagg tgtgtcagcc gttgttgccg agctgaatcc 183301 taaatcccca aagaaaactt cgcggacact tcggttatga gccagataga agttttgctt 183361 atgcagcctc aaaaagagaa aacgcagccc ttgaacgtgc tgaagtgttt ttttggcggc 183421 cgttgtctgc tggtcataat ccgctagcca cttttctgct tcggactcct cctttaaaaa 183481 tgaggcagtt tgcagaaagt gggttctcca gctttcttct gaaggaaggt acatgacttc 183541 tgcgatgcga ttcaggcgat cttgttcttc tggagaaata gaatccatgc tgacaatcac 183601 atctggttct gcctgtgata acgtgtacag gttttcttcc cacttttcat taaaccggta 183661 tgcactgagc tggacgggta tatctgtcga ataatgctga tagtagtaag acgtccattt 183721 cggatgcaga gcggccgcaa aaggtatgtg gtgaagaggg atgagatggc ccattgtgcc 183781 ccttccgtat gcggcgattt tctttcggcg ttttttcata tagcttgtag gtgaacagcc 183841 tgtatatttt ttaaagattc tgctgaaata aaattcatct tgataaccgg tttggtgtgc 183901 gatttctttc aatttgcagt ttgattttgc catgagccgt tttgcctttg tgattcgtgt 183961 tttcgtaata aattctgtta cgctctgtcc tgtccatttt ttaaagcttt cactgtagtg 184021 tttggcactg attcctgcca tttgcgacag ctgggcaagc gtgatttttg tatcggcatg 184081 ggtttcgata tagtgttttg ttttttcgat tgctgaatgt gtatccgttt gatcagataa 184141 actggcagta aaaagatcat aaatcaggct ttgtacttca atcacacatt ttagctgaga 184201 aagctgagac gattcattcc atagtgcggc aagctcttga agccggactg caagattttc 184261 gatatgtgaa acattcataa gcttcagttt ggctaattcc gattctgtgc acggtgtgaa 184321 aatatcttgc ccggtttcct tgatatagct tagaagcctg attatacagg catctatatg 184381 tccatcggct gctggcgtaa agccaaaggt ctcgttaggc ggacaaacat aaagtgtctt 184441 tttttgcaga ggattggtgt ttgttccgat cgaaatatag ccgtttcctt ttaaatgaaa 184501 aatcagcacg aatgaatcgg ctaattgctg ttctgagaag agatcacttg tcttttttag 184561 atattcaatt tgtactggtt gataaatcac tgcattttgc acgagtagac caccttttca 184621 gaagctttca attgataatc attttcaata aaaattgtac caaataaatg aaagttttcc 184681 tatataaagc gggtgggttt ttagcatgaa aaaaaccctt acttatgtgt aaaagtaagg 184741 gtctttcgtt caataagaat atgttacacg tgtaacatac gatgcttatg ttctaataaa 184801 tgagatactt ttttcttgtt ttgctgaatt gttggagtgt tttttcatag ctgtttatga 184861 tgttctcaac cgaagttcca ttttcaattt ttgtcctgat ccagccgttg cctgccagtt 184921 tatcgaatga acctgttgac aggaactcaa aatcctcagg atagagatcg tgtatggttt 184981 taatgactga aagacccgtt ttaacggctt caaacttatc tctgtctgtc acatagagct 185041 gcacaccgtg gcaaagcgtt ccttgatgtt tagaaaacgt cggtgtgaag gatgctgccc 185101 taaatgtaac gcccggcaaa tggaggctgt ttaatgtttc ttcaagttct gtgcttttga 185161 taaagggagc tccgatcaat tcgaatggct ttgttgtccc tcgcccttcg gatatatttg 185221 ttccttcaat cagcccggtt gcaggataaa caaatgtgct ttccaccgtc ggcatgttag 185281 gcgaagggag gacgaaaggc aatcgggtat cgtcaaaatc catttttcgt ttccagtgtt 185341 tcatttttac cactgtaaga tcggcatcaa tactaaattc tttgttgaac agtgaagcca 185401 attcgcctat cgtcatccca tgcttcaatg gaatgggata caatccgaca aatgaggcgt 185461 attcaggttc taagattggt ccttcaatat gattcccgcc ttgaggattc ggacggtcca 185521 gcaccataaa tggaatgccg ttttctttag cggcttccat tgcgtatgcc attgtataaa 185581 tgtacgtgta gaaacgggtc ccgacatcct gaatgtcaaa cattagaata tcgacatttt 185641 taagcatttc tggagtcggt tttttcgttt ttccgtagag gctgtatacg ggaaccccgg 185701 ttttttcgtc aatgtaagag cctacttcgt ctccagcctg ggcgtcaccg cggacgccgt 185761 gttcagggcc gaataaagct gtcagtttga tatccgggtt ctcgtaaagg atatcgacac 185821 tgctttttag agatgtgttt actccggctg gattggtgat cagtccgatg cgttttccct 185881 tgagctgttt tttatagtct ggcaagagcg tgtctatccc agtctggact ttaggttttt 185941 tagctgtttg attctttgaa tcgggtgaag cagaggcagc ggttatcgtt ccgaacatca 186001 tgagccctgt cagaaaagcg aatattgttt ttctcatgtg tccctcctta ttaaagcggt 186061 cttcccgttt tgatatttaa tccgtagcca agtgggtaaa gggtgttccc tggtttcgtg 186121 actgacggaa tgtcaactgg aagtgtgcct ttaggttttg cctggccgaa tatcgccatc 186181 actccggccg gaatattagg ttgaagataa cggccatttg cgtatccttt aaagccatag 186241 actgcaatca gtgcttttgc ttcttcgaaa ttggctgcgt cataggggtt gcgcaggctc 186301 attaagacaa atggtttgtt gtgctgcagt gcggctttca tgacagctct cggaaacacg 186361 gtggcccatt tgcttgaatc tgatattgtg tcgtcgatga caccgtcgtt gacgacaggg 186421 tcatttttga cgacatagga gccggtaatg atataatcag cctcttttac ttgtttttca 186481 tgctcggtct taaatacttg gctggcaaag ttcattttgc tgagggatac gggtttgatt 186541 ttctttcgct tgatgagatc gtgaatggtt tgttcgattg aagcagtttg ttcttcgtaa 186601 ggtgccacaa ttaagattcg gctgcctttt ttaggcttga acggcaaagt gtgctgttca 186661 ttttttaata cagttactgc tttttcagct aattttttct ctgctttcag gtgctgcttg 186721 cttcctacga tttttttggc tttggctatt ttttcttttg tactgtcgct gtttcgcgct 186781 ggatacatgc cgcgttttat tttcagggaa atgattcttt caactgaatt gttgatttgt 186841 tgttcaggaa tatccccgtt tttcacggct tctttcaaag cttgaataac acgtgcgaat 186901 ttctgttctt ctttcaatga agtgactgag gctggcatta atgcaatatc gacaccagct 186961 tttacggcca tgaccacagc ctcttcctgt ccgaaatgat ctgcgattgc cttcatattg 187021 agcgcatcgg taacgatgac cccattaaag cccatttcct gacgaagaag acctgtcatc 187081 actttttttg aaagtgtagc tggaaccaga atgtccgatc catcgagttt gcttttgtaa 187141 gtggtgtcat caaaggcggg aaactgaaca tgggctgtca tcaccatatc agcaccagca 187201 tcaattgctt tttgaaaagg ataaagctcg acctcacgaa gccgttcttg gccatgggaa 187261 acgagcggca gtccataatg gctgtcaacg tccgtgtctc catgtcccgg gaaatgtttg 187321 agggcagacg cgatatcctg ccgctgcaac cctttcatcg tatataaacc gaggcgtgat 187381 gtcagttctc gattggagct gaatgaccgt acgccgatta caggattatc aggattattg 187441 ttaatgtcca cgacagggct gaaatctgta ttgatgccta aggcagagag ctcttttccg 187501 atgatgctgc cggtctgata cgcattgatt ctgcttctgg ctgcgcccag cgccatattc 187561 cctgggaaat tagtgccctc ccctaacctc gttacaatgc cgccttcctg atcaatactc 187621 agcatgagcg ggatttttgg acttgccttt tggtaatcgt ctgtcagttg gacagtttgt 187681 tttgttgttt ttacattttc tgcaaaaagg atgatgcctc cgaattgata tttcttgacg 187741 aggctggcga cttcatcatt catttttgta agggcttgcg gagaggactc gccttccttt 187801 tgccaatttc taaaatcagg catcagcatc tggccgagtt tttcatctaa cgacatacga 187861 ttgacaatct gattggcatc gattgcacgt ttggatgcag aggcttctgt ctgtctggcc 187921 ccgaaaaagc atgaaagaaa gagaacggct gaaaggataa gcggaaagac aggtctcata 187981 gaaacttcct cctatcgtct aatcattcac tccatcgctt cataaatcgc ggttatgaca 188041 cttccataac tgcctgttgg aaattggtca ccttcaaaga cgttcggatt ttcttccgga 188101 tcaataactg gtgtatgctt tttatttgtt aacaatgcga tgcctaaatt gtatgctgga 188161 tcaataattg taactgtccc cgtccagccg gtatgcccgt aagcattttc gctggcatga 188221 gggccaaaca tccattccat gcttttactt ccgttccgcc tccagccaag agcgaatgtc 188281 ggatctgttg ctgaaggtgc tgtaaacagg tcggctgttt tctgatcaaa taaagaaatg 188341 tttcggtatg aacctttgtt taacatgact tgcagcagta tggccatatc atctgcattt 188401 gagaacaatc cggcatgccc agacacgccg tccattgagt aaaacgcttt ttcgtcatgc 188461 acctctcctt gcagcgtgtt tgtgcggatg ttagggaatt gaataacgcc gtcacgtgta 188521 ttgcccatgc gttcagtagc tgcgaactgt ttcggtttaa agcccttttg cagcggattg 188581 tacaaggtat gcttcagcct gagcggtttg tagagctctt gctccgtgta gacatcaagc 188641 ggtttgccgg tgagtttttc gacaatacat ccgagtagca tatatccaat gtcactgtat 188701 acgtgttttg tcccggtttg ataatcgagc ggaattttcg tcaaatattc aatcgttttg 188761 tcccgttctt gggaatagta cttgccggct ttttccggcg tgtaaaagta aaagcttgat 188821 gggagccctg attggtgctg gaggacatca atgacacgta tcttgtcttt tccttttatg 188881 aggtcacccg gctgatcctt gaaacccggc aaatatgcag aaactttttc atagacgtca 188941 agttttcctt ggctgactaa gcgctgcaat gcaaaatttg ttgcgtacat ttttgtattt 189001 gaggctaagt caaacatcgt gcgggttttc attttggccg gacggcgcag cagttctgat 189061 ccttcgtact ttttactgta gccgtatgct gcttttttta tgatgcgtcc atccttcacc 189121 accacaagaa cggcgcctgg aaatcctgct gcaatatccc gttctatcat ctgatctacc 189181 ttccttagct tcttcgtcga gaattgtgca gtttctgcat ttatgatttt cggctcaatc 189241 aagttgcctg ctgtttgtgc gaaggtttca tttggcgcaa atatcgatag ggttaaaatg 189301 gcactgaata tgaacagtgt ctttgttttc acaggctagc ccctttctgt gcttctatcc 189361 cgtttactat ccctaaaaca gaaacaattt aatcgaactg agaagccatt tcatctttat 189421 atccgaatgc ataggtcaat aaaaaaccgg ccgcgtagga aataaagagc ccaacgatat 189481 acaggatgat ttgcgaaggc aggactagaa aagatagcgg cagtccggag acaccaatcg 189541 caatggtggc tacttgaaaa taagcttgaa aggcgccgcc gattccagct cctaaacatg 189601 ctgttaaaaa cggacggcca agcggcagcg tgactccgaa aataagcggt tcaccaatgc 189661 cgagcagtcc cgatggaagc ccgccggcga ttgctttcct cagtgttgtt tttttcgtct 189721 tcacgaaaac ggcaaaggcc gcgcctacct gtcctgcacc tcccatagcc aaaataggga 189781 gcagaggatc attgccaatt gaattgatca gttccatgtg cacaggcgtc aagccttgat 189841 gcagtccggt tacgacgaga ggaaggaagg ttgcgcccag aataaagccc gcagcgatgc 189901 cgccgatgtc caggatggac agtaggccgg atgtaatagc atcagaaatg aatccgccta 189961 aaggcataaa tacgacatac gttacgattc cggtgattaa cagtgaaacg gtgggtgtga 190021 caatgatatc aagtgattga ggaataaaac ggcgaataaa ttgttcggtg taagcaatga 190081 atatggctgc gaaaaggacg ccgatcagac ctcccctgcc cgggagaagc tcttctccaa 190141 ataaactgat ttttgcgatc tccggattga taatcaagat cccggccaaa gccccaagtg 190201 cgggtgtccc gccaaattct ttcgaagcgt taataccgac gagaatgccg agataagtga 190261 acagccctga tccgatgact gtcaggataa tcgcaatttg tgagtctgca gagagccagc 190321 ctgcttgaat aattgctttg gtaatcccag taattaaacc ggaagcgact agagcgggaa 190381 taagagggat aaaaatgctg gcaattttac gtaagaaaag tttaaaagga gtggcatttt 190441 tccgattgat atcggctttc tttttggccg ctgcttcttt gacatcggca ccttcttctg 190501 ctgacacgag ctttgagaaa gcagctgtaa catgattgac aactcctgtg ccgaggataa 190561 tttgtaaggt ttcagcttca acgaccccca atacgccgtc aagctttctt aaagcctgag 190621 catccgcttt gctttcatcg taaggcgtaa tgcgcaggcg tgtcatgcaa tgcgtatatg 190681 aagaaatatt ggattttcct ccgcatagct caaggatttt ctgtgcgaga tgatggtagt 190741 tattttcttt gctcattaaa acccctcccc ttcaagatgc cttattttat tctcatagat 190801 tgtatggctg ctctcgtttt atctatataa ccggttgtcg tttcatactg ctcagccgcc 190861 atgcctaaaa acaaaacatc aattataaaa agctgggcga ggcgggaaga agtggctgca 190921 cttcgaatca aggcttcatt ggaatgggct gtatacaaag ggacatcagc cagtgcggag 190981 acggatgtct gactgaattg tgtgaggctg atcgttgtga tgcctttttc cttagccatg 191041 gcgaacagtt caacgatttc ctgtgtctct cctgaaaacg aaatggcgaa tacgatgtcg 191101 tctttatctg catttgcgat taaagatgcc acaagatgag tgtctgtaaa cgcggttgct 191161 tgtttatgaa tgcgaagcca cttttgctgg gcgtccttgg cgacaatgcc ggaagccccg 191221 aggccgataa aatgcacggt atgagctttg agaagcagag aaaccgctcg ttcaagctct 191281 ttgtagtcca tcaggtctga agtatcctga atggcttgaa tggcattgcc ggccgttttt 191341 tcggaaatgg agggcagcgg ctcgtgggga acaatatccc ggtagccctg aaacgtaggc 191401 tttgccagat cgcctgctac tctcattttt aaatcttgaa atccttttaa accgagtgat 191461 ttgcagagcc tgatgacggc agcgtcactt gaattggcta aggcgctgat ttcgttgacc 191521 gtgctttcga ttgctttgtg gggatgggct aggatataat ctgcaagttt gcgctcggat 191581 ggagggagct tatgcttcat tgattggatg atcgctaaac cgcctgtggc cattctagtt 191641 ctctccttat catggatggt aatgttcgat tgctttgtca atgaaaccgt ttgcttcatc 191701 gagtaatgtc tgtgcttgtt tctgatctgt gcttgttttg agcatgacga ttgctgtttt 191761 gacgtgatga tcggcttgtt ccagagtgta tctggctgtg tcgtatgaag cgtttgtaag 191821 gctttggatg atgctgatgg cgcgttcttt tagttttttg ttgctgacgt tgacgtctac 191881 catcaagttt tcgtaaacct tgccgatttt gaccattaca gcggtagata tcatgtttag 191941 aatcatttta tgagcggttg cggctttcat acgtgttgat cctgtaatgg cctcaggtcc 192001 gacgacaacc tcaatgctgt gatccgcatc cttgctgatg gcggaatttt cattgcaagt 192061 aagggcgatg gtgtgtgctc cgactttacg ggcgtatctt agggcgcctg cggcgtaggg 192121 tgtgcggccg cttgctgcga tggcaatgac ggtgtcattt gaagtgagct gtatgtttct 192181 taaatcttca gctcctgctt cttcactgtc ttcaatgccc tctgctgcct gtaaaaaggc 192241 ttcggggcct ccagccatga ttccgatgac ctgatctggg cttacgctgt aggtgggagg 192301 acattcaaca gcatccatga cgccgagtct gccgcttgtg ccggcgcctg tatatatgag 192361 ccggcctcca ttttgaaacg attcatatgc gcagtctaca gctgttttga tgtcggggag 192421 aacctcctga acggctgcag cgactttcat atcttcgttg ttgatcattt taaggatgcc 192481 gagagtgttt gctttgtgga tttcaactgt ttgactattg cgtgattccg ttgtaagacg 192541 gtgaaggttt aatggttctg acatgaggat gccccctgtt ttaaaatgat atatctcaat 192601 attcagtata ttcatttctg ttatgatatt tcaactatgt ttttaaattt ttgaaatttt 192661 atttcactta agactataag aaatgatgaa ggatcaactg ttctccaagc ggcccgattc 192721 ttcgccgtcc tttatcaagg aacccgcttt tcatataaag gtgttttgcg cgtatgttca 192781 gatgattgac ggccaagatg atttcgtcgc accatggaaa atatccgctc acaaaagcgg 192841 gaagcaaaag catggctttt ttcgcatagc cttttccgtg atgcacagcg gttaaagaca 192901 gggagctgag cagtaaagca aatggattgt tagaatagga agcaagcgtt tcttttgatg 192961 catgtaaaat gaaaaaaccg actggaaggt cgtcttttaa gatgacaacc gggtatcggt 193021 cctgtatgcc cagagcctga gacagcacct ctttcgggag ggaggtaaag cgtttgtcat 193081 cgttggtgag cgtgaatgat tggagctcgg gcaagtgttc aggcttatag aaggataaag 193141 aaatgtcttg agtcatgggg tggcctcctt acaatatgtc gttaagctcg ttttccgaaa 193201 tgacgcggta gcccgcttgt tttaacagtg cggcggttac tccgctgccg gtgatttttt 193261 tgccagagaa tgtgccgtta tagataaaac cgcttccgca agatggactg ttttctttta 193321 atatgacggc agaagcgttg atttcttttg cgtaagccaa tgttttcgcg gcgccttcca 193381 tatatagttc tgtgacgtct tctcctgaag ctgtcacgat tttcgctgtt ccattgagga 193441 catcctcgcc agtgcctcct atgatttctg cgggttcgcg tggggtagag aagccgccga 193501 gaagttcagg gcaagccatg actgctttct tttcatcgac tagttttctg attttctccg 193561 acgctgcgtg agagccgtta tatctgcatt caatgcctcc aaggcaagaa ctgactagaa 193621 tcatattggt ttctcctctc ttgctttgct tgtctctatc ataaaataaa tggctttagt 193681 tgggaggctt tttcagttaa aaaaggagtt aaaaagtttg aaaataaaaa atttaatttt 193741 cctctttaca aacagggggt gacctgtata taataacttt tgtcagctcg acgagaacac 193801 aacggcccgt tggtcaagcg gttaagacac cgccctttca cggcggtaac acgggttcga 193861 atcccgtacg ggtcaccatt tggaggatta gctcagctgg gagagcatct gccttacaag 193921 cagagggtcg gcggttcgag cccgtcatcc tccaccatct tgccggtgta gctcaattgg 193981 tagagcaact gacttgtaat cagtaggttg ggggttcaag tcctcttgcc ggcactgttt 194041 tttcaaaatt ttatgtggag gggtagcgaa gtggctaaac gcggcggact gtaaatccgc 194101 tccctcaggg ttcggcagtt cgaatctgcc cccctccacc attattgggc tatagccaag 194161 cggtaaggca acggactttg actccgtcat gcgttggttc gaatccagct agcccagtca 194221 cagacacctt tgatcaaaag gtgtcttttt tcttttcgga aaaatcattc caacttctaa 194281 ctgttcagtc tgtataataa ttttaaaaat atgttaaggt agtttattca cgaattacca 194341 tctacaccct gccaaaaatt tgataaactt attttataaa aaaattgaaa ccttttgaaa 194401 cgaagctcgt atacatacag accggtgaag gcagaggtta gataaatatg gaaatgatga 194461 ttaaaaaaag aattaaacaa gtcaaaaaag gcgaccagga tgcatttgcg gacatcgtag 194521 atatttacaa agataaaatt tatcagcttt gctaccgtat gcttggcaat gtgcatgagg 194581 cggaggatat tgcacaggaa gctttcatca gagcgtacgt taatatcgac agttttgata 194641 ttaaccggaa attttcaact tggctttatc gaatcgcgac caatttgacc attgaccgca 194701 ttcgcaaaaa gaagccggat tattacctcg acgcagaggt ggctggtacg gaaggcttga 194761 ccatgtattc tcaaatcgtc gcagatggtg ttttgcctga agatgcagtt gtatcgctgg 194821 agctctcaaa cacgatacag cagaaaattt taaagcttcc tgacaaatac agaacagtca 194881 tcgtattaaa gtatattgac gaactctcat taattgaaat cggggagatt ctaaacattc 194941 ctgtggggac tgtgaaaacg cggattcaca gaggcagaga ggctcttaga aaacaattaa 195001 gggatcttta agtggggtga tgaaatgagc tgtcctgaac aaattgtgca gcttatgcat 195061 atgcatcttg atggagatat ccttccaaaa gatgaacacg tattaaatga acatctggag 195121 acatgcgaga aatgcagaaa gcatttttac gagatggaga aatccatagc gctcgtacgg 195181 agcacatcgc atgtcgaagc ccccgcggat tttaccgcta atgtcatggc aaaattgcct 195241 aaggagaaga aaagagcttc tgtaaaaaga tggttcagaa cccatcccgt tatcgcagct 195301 gctgcggtat tcatcatttt gatgggcggg ggttttttta acagctggca taatgaccac 195361 aatttcagcg tgtccaagca gccgaatctt gtggttcata accatactgt gaccgtgcca 195421 gaaggtgaga cggtcaaagg tgatgtcact gtcaaaaacg gcaagctgat tattaaaggc 195481 aaaatagacg gggatgtaac cgtcgtaaac ggcgaaaagt atatggcctc tgctggacaa 195541 gtcaccggtc agattgaaga aatcaatcag ttattcgact ggacatggta caagatgaag 195601 tctgcgggga aaagtgtact cgatgcattc aatccgaacg gagaagagta aagcgcgtta 195661 gccgctttgc tctttttttg cgggctgaga gggctggcac atttcacttg ctaaatcgaa 195721 atgtggtata atgggctcgc tatgtaaagt acatatgcgt aacacgtaaa acacaaaata 195781 cgaaatgact gaaatcttgg aggacgagga aatggctttt gaggatatcc cttttttgca 195841 gtacctcggc aatgccgttg atattctcct tgtttggtat gtgatatata aattgattat 195901 ggtgatacgc ggcacgaaag cggttcagct gttaaaagga attgtagtca tcgtgcttgt 195961 tcgtatggcc agccaatatt tgggcctcag cacacttcaa tggctgatgg accaagcgat 196021 aacatgggga tttttagcaa ttattattat ttttcagcct gagctgagaa gagcgcttga 196081 acagctaggc cgcggccgct ttttttcgag gagcggcacg cctgttgaag aagcgcagca 196141 gaaaacgatt gaggccatta caaaagcaat caattatatg gcgaaacgcc gtataggcgc 196201 cctgctgacc attgagcggg atactggaat gggcgattat attgagaccg gcataccact 196261 aaatgccaaa gtcagctctg agctgctgat caatattttt attccaaaca ccccgcttca 196321 tgacggtgcg gtaattatga aaaataatga aattgccgcg gccgcctgtt atctgccgct 196381 ttctgagagc ccgtttattt caaaagaact gggcacgcgg cacagagcag ctgtcggtat 196441 cagtgaagta acagacagtt tgacgattat tgtgtctgaa gagaccggcg gcgtcagtgt 196501 ggcaaagaac ggcgaccttc acagagagct tacagaagaa gcgctgaaag aaatgcttga 196561 agccgagttt aagaaaaaca ccagagacac ttcttctaac cgctggtatt ggaggggcaa 196621 gaaaaatgga taaattctta aacaaccgct gggctgtgaa aattattgct ctgcttttcg 196681 cgctcttgct ttatgtggcg gttaacagca accaagcacc gactccaaaa aaaccgggtg 196741 aatctttctt tccgacatca acaactgatg aagcaactct gactgatatt ccggttaaag 196801 cgtattatga tgatgaaaat tacgtcgtga cgggtgttcc gcaaacggtt aatgtcacga 196861 taaaaggctc gacaagcgcc gtgaaaaagg ctcggcagac caaaaacttt gaaatatatg 196921 ccgatatgga acatttgaaa accggcacac ataaggttga gcttaaggcc aaaaacgtgt 196981 cggatgggct gacaatctca attaatccgt ctgttacgac agtgaccatt caggaacgga 197041 cgaccaaaag ttttcccgta gaagtggagt actacaacaa aagcaagatg aaaaaaggct 197101 attctccgga gcagccgatt gtcagtccga aaaatgtgca gattaccgga tcgaaaaatg 197161 tgatcgataa tatttctctt gtaaaagctt cagtgaattt ggaaaacgca gatgaaacga 197221 ttgaaaagga agcgaaagtg actgtctatg ataaagacgg aaacgcgctt cctgtcgacg 197281 tggagccctc ggtcatcaag attaccgttc cggtgacaag cccgagtaaa aaagtgccct 197341 ttaaaattga acggacagga agccttcctg acggtgtcag catagcgaat attgaatcca 197401 gccccagtga ggtaacggtt tacggctcac aggatgtgtt ggattctctt gaatttattg 197461 acggcgtcag cctagattta agtaaaatta acaaggattc cgatatcgag gcagatattc 197521 cgcttcctga cggtgtcaaa aaaatctcac cgtcaaaggt gactttgcat atagaagtcg 197581 atagtgaagc ggatcagaag ttcgagaatg tccctatcaa gactgtaggg ctgagcagct 197641 cacaaaacat tgaatttctt gatcctgaat cacaagcgat agatgtaacg gctaaaggct 197701 ctcccacgaa tataaataaa ctgaaaaaat cagatattga attgtatgtg aatgtttcag 197761 atttagagga cggggagcat agcgtgaagc ttgaagtgaa cgggccacag aatgtaactt 197821 ggtccttggg gcggaaaaac gccaaaatca agctgacgtc taagaaaagc aatacatcaa 197881 cgaatgataa cagcagcaat acatcaggga accaggacac agataaacaa acaaatgatc 197941 aaaagaacaa tcagcaagaa gatacaaaga acactgataa aaacaacaac gatcaaaacc 198001 aagacggaaa taaagatcaa aaccaagatc aggatgagga tgaatccact gcgaattcac 198061 aatcctcatc ggaataaaaa aggagcgatt ataaaatggg caagtatttt ggaacagacg 198121 gtgtaagagg tgtcgccaat agtgagctta cacctgagct ggcctttaaa gtcggacgtt 198181 tcggcggtta tgtgctgaca aaagacaaac aacgtccaaa agtgctgata ggccgcgata 198241 cacgcatctc cggccatatg ctggagggag cccttgtcgc cggactttta tccattggcg 198301 cagaagtcat gcgcctgggt gtcatttcta caccaggtgt atcttatttg acaaaagcga 198361 tggatgcaga ggcgggcgtc atgatttccg cttctcataa cccagtgcag gataacggca 198421 tcaaattctt tgggggagat ggatttaagc tttctgatga acaggaggct gaaattgagc 198481 gcctgatgga cgaacctgag gataagctgc caagacctgt cggagcagac cttggacttg 198541 taaacgatta ttttgaaggc ggacaaaaat atctgcaatt cttaaaacag acagctgatg 198601 aagatttcac aggcattcat gtggcattgg actgtgccaa tggcgcaacg tcatccttgg 198661 cgacacacct gtttgctgat ttagatgcag atgtttctac aatggggact tccccgaacg 198721 gattaaacat taatgacggc gtcggttcga ctcatcccga agcgctcagc gcgtttgtca 198781 aagagaaaaa cgcggatctc ggtcttgcgt tcgacggtga cggcgaccgc ctgattgctg 198841 tcgatgaaaa aggaaatatt gtagacggcg accaaatcat gtacatatgc tcaaaacatc 198901 tgaaatcaga gggccgttta aaggatgata cagtggtttc aaccgtgatg agcaacctcg 198961 gcttctataa ggcgctcgaa aaagaaggca tcaaaagcgt gcagacagct gtcggcgacc 199021 gctacgtagt agaagcaatg aaaaaagacg gctacaacgt cggcggagag cagtcaggac 199081 atcttatttt ccttgattac aacacgacag gggacggatt attgtctgct attatgctga 199141 tgaacacttt aaaagcaaca ggcaagccgc tgtcagagct tgcagctgaa atgcagaagt 199201 tcccgcagct gttagtcaat gtgagagtga ctgataaata taaagttgaa gaaaatgaaa 199261 aagtaaaagc agttatttct gaagttgaaa aagaaatgaa cggcgacggc cggattttgg 199321 tgcgcccttc aggaactgaa ccgctcgtcc gtgtcatggc tgaagcgaag acgaaagagc 199381 tgtgcgatga gtatgtcaat cgcattgttg aagtcgtccg gtcagaaatg ggattagagt 199441 aacgaagtct attatcagag agtgaacaag acaagcgagg tttacataag ataattgtga 199501 gacatacggc aaagttgctt aaaaaacaat tgaccgttta tgccacatgt tgtaaaatca 199561 agcttgtctt gttcttattt tctcaatagg aaaagaagac gggattattg ctttacctat 199621 aattatagcg cccgaactaa gcgcccggaa aaaggcttag ttgacgagga tggaggttat 199681 cgaattttcg gcggatgcct cccggctgag tgtgcagatc acagccgtaa ggatttcttc 199741 aaaccaaggg ggtgactcct tgaacaaaga gaaatcacat gatcttccaa aaaacatgta 199801 ggaggggacg attgaaagtc cccttgaaat ttgactttct tcgtctcctt ttacaatctt 199861 aggaggaaga aaaatatgtg tggaatcgta ggttatatcg gtcagcttga tgcgaaggaa 199921 attttattaa aagggttaga gaagcttgag tatcgcggtt atgactctgc tggtattgct 199981 gttgccaacg aacagggaat ccatgtgttc aaagaaaaag gacgcattgc agatcttcgt 200041 gaagttgtgg atgccaatgt agaagcgaaa gccggaattg ggcatactcg ctgggcgaca 200101 cacggcgaac caagctatct gaacgctcac ccgcatcaaa gcgcactggg ccgctttaca 200161 cttgttcaca acggcgtgat cgagaactat gttcagctga agcaagagta tttgcaagat 200221 gtagagctca aaagtgacac cgatacagaa gtagtcgttc aagtaatcga gcaattcgtc 200281 aatggaggac ttgagacaga agaagcgttc cgcaaaacac ttacactgtt aaaaggctct 200341 tatgcaattg ctttattcga taacgacaac agagaaacga tttttgtagc gaaaaacaaa 200401 agccctctat tagtaggtct tggagataca ttcaacgtcg tagcatctga tgcgatggcg 200461 atgcttcaag taaccaacga atacgtagag ctgatggata aagaaatggt tatcgtcact 200521 gatgaccaag ttgtcatcaa aaaccttgat ggtgacgtga ttacacgtgc gtcttatatt 200581 gctgagcttg atgccagtga tatcgaaaaa ggcacgtacc ctcactacat gttgaaagaa 200641 acggatgagc agcctgttgt tatgcgcaaa atcatccaaa cgtatcaaga tgaaaacggc 200701 aagctgtctg tgcctggcga tatcgctgcc gctgtagcgg aagcggaccg catctatatc 200761 attggctgcg gaacaagcta ccatgcagga cttgtcggta aacaatatat tgaaatgtgg 200821 gcaaacgtgc cggttgaagt gcatgtagcg agtgaattct cctacaacat gccgcttctg 200881 tctaagaaac cgctcttcat tttcctttct caaagcggag aaacagcaga cagccgcgcg 200941 gtactcgttc aagtcaaagc gctcggacac aaagccctga caatcacaaa cgtacctgga 201001 tcaacgcttt ctcgtgaagc tgactataca ttgctgcttc atgcaggccc tgagatcgct 201061 gttgcgtcaa cgaaagcata cactgcacaa atcgcagttc tggcggttct tgcttctgtg 201121 gctgctgaca aaaatggcat caatatcgga tttgacctcg tcaaagaact cggtatcgct 201181 gcaaacgcaa tggaagctct atgcgaccag aaagacgaaa tggaaatgat cgctcgtgaa 201241 tacctgactg tatccagaaa tgctttcttc atcggacgcg gccttgacta cttcgtatgt 201301 gtcgaaggcg cactgaagct gaaagagatt tcttacatcc aggcagaagg ttttgccggc 201361 ggtgagctaa agcacggaac gattgccttg atcgaacaag gaacaccagt attcgcactg 201421 gcaactcaag agcatgtaaa cctaagcatc cgcggaaacg tcaaagaagt tgctgctcgc 201481 ggagcaaaca catgcatcat ctcactgaaa ggcctagacg atgcggatga cagattcgta 201541 ttgccggaag taaacccagc gcttgctccg ttggtatctg ttgttccatt gcagctgatc 201601 gcttactatg ctgcactgca tcgcggctgt gatgtggata aacctcgtaa ccttgcgaag 201661 agtgttactg tggagtaata attaattaac ccctttggat aagaaggtct tcacatgtgc 201721 tgctaggctc caaatgtaca cctttccgta agggcaaagt caaatgtgaa aaaaaactgt 201781 tccaaagtta atcagaaatt tattttcata ttgtatcctt cggtatcaag tgaaaggagc 201841 atcatatgaa aacattatgg aaagtcctca aaattgtttt tgtcagcttg gctgctttgg 201901 ttttgcttgt atccgtctcg gtatttattt atcaccattt ccagctaaat aaggaggcgg 201961 cactgctgaa aggtaaaggc acagtagtcg atgttgacgg taaaaagatg aatgtgtatc 202021 aagagggaag cgggaaggat acgtttgtgt ttatgtccgg ttcgggtatt gctgcgcctg 202081 cttatgaaat gaaggggctg tacagcaagt tttcaaaaga aaataagatt gctgttgtag 202141 atcgggcagg ttatggatac agtgaagtgt ctcacgatga cagagatatt gatacggtat 202201 tggaacagac gaggaaagcg cttatgaaaa gcggaaataa gcctccttat attttaatgc 202261 ctcattcgat atccgggatt gaagcgatgt attgggcaca gaaatatcct aaggaaatca 202321 aggccattat tgcgatggat attggattgc cccagcagta cgtcacgtat aaattgagcg 202381 gagttgaccg attgaaagtg agagggttcc acctgttaac ctcgattggt tttcatcggt 202441 ttataccttc cgctgtatat aatcctgagg tgattcgaca gtcgttttta actgatgaag 202501 aaaaagaaat ctataaagcc attaacttta agcaattttt taatgcagat atggagcatg 202561 agcttttaca gtcttaccaa aacggcagca aatctgtgaa tctgcctgcg ccaaaggaaa 202621 ctcccgtctt gattttagat gcagtctctg accaaaatag acattcaaag tatgctatac 202681 aaaaccgaaa agactatgaa gcgtttgcgg ctcaattcaa tactgccgat ataaaggaac 202741 tgaggggaac acacagtatt tatttatatc agcctgatca aatatataaa ctgtccatgg 202801 agtttatgag aaaggttcgc taggatgaag ggttatcgta ttttaatcgt tgaggacgat 202861 gtgatgattg gtgatttgct gcaaaagatt ttgcagcgcg agggatatcg tgtgatatgg 202921 aaaacagatg gagcggatgt gctttcggtg attcagaagg tggatttggt cattatggat 202981 gtgatgctgc cgggtgaaga cgggtatcaa atgtctgcaa aaatcaaaaa gctggggctg 203041 ggcattccgg ttatttttct ctcagcccgc aatgacatgg acagcaagct tcaaggtttg 203101 cagatcggcg aggattatat ggtaaagccc tttgatccga gagagctgct attaagaatg 203161 cggaatatgc ttgagcatca ttatgggacc tttacgcaaa tcaaacattt gtatattgat 203221 gcggtaacga aaaaagtgtt caatgaaagc ctgcatgatg aggtattatt tactgcgatt 203281 gagcggaaaa ttttctttta tttatatgaa aatagagaca gtatcctgac aaaggaacat 203341 ttctttgaat atctatggca gctcgaagat agaaacccga atattgtcaa tgtgcatatt 203401 aaaaaaatta gagctaaaat caatgatcaa gcgggtgaga tgattgaaaa tatatatgga 203461 gaagggtatc ggctgaatac cgttgtgaag aaatgaagct caagacaaaa tatcagttgt 203521 tattgtttac ggccgtcatt agtgttccga tgctattgct ggcggtcagt gttttgatgt 203581 cggtgattta tgacagcatg tttaaaccga tgaatcatgg tatgcccttt cacaggtcgt 203641 ttgcataccc ggcaatgatc gttgtatttt tgatatcact cttattgtta gcttttttat 203701 tttcaaagtc gattcattct ctgttgcata aaatcaatct attaaatcaa accattcggc 203761 atttggcgag tgatcaaagg gtgcccgata aaattgaagt gaagcgtgct gatgaaatcg 203821 gggaactgat caagtcggtc aatttgttaa ttgaacggac gacatatcgt gaactggagc 203881 tgagacagca ggaggaaatc aaaaaggagc ttttgcaaaa actgcggcat gacattaata 203941 cacctttaac ggctctcagg ctgcagttat tttatttgga agaccaatgt catggtcagg 204001 ctgtattcga atcattgtat cagcaaatcg aatatatctc ggaattaact aatgaattca 204061 atctatattc cgctgagacg ctggaaagct cttatattgt aaatgaagaa gtgcgtctaa 204121 acgagctatt agaaacagcg gtgaaaaagt gggattattt atacagtatg agtgggattg 204181 agctgcacta taagccggca gatcaagatg tgatatggat gagcaacacg ttatggatgg 204241 aaaggctgtt tgataatatt tttcaaaata cgttaaggca ttcaaaagct aaaaagatgg 204301 aagtcacgat tgaacatggc gatgttttta ttcgtgatga cggtattgga tttgatcgga 204361 atgagagcag tgagggactt gggttaaaga ttattgagga tacatgcagg ctgcttgcga 204421 ttacttatga gctgcataca aatgataacg gaacggggtt cttgttttca aaagagtgac 204481 cccgctgatg tttttctttc tcctataaaa tttatataat agggagaaag aaatggggtg 204541 aacatcatat gtttaaaaaa atcatcaaaa cgattaagta cctctcaagc agttctagtg 204601 accgatatcg cagacaccgg cattacagca gcagccggcg cagacattat cgcagctaca 204661 gcagcagttc gggcaaaaga agacactacg accgttatgg cggcagtcat cgttacaaac 204721 gccggagcta cagcagcagt taatccaaaa aaagttcttg ttccgctttt gggacaaggg 204781 tttttttatg tgaccgattg aatggcccgg tttagatcct cgcgaatgga agcggtgtgc 204841 tgatactctt cctcaatgcc caataatctt ttcagcagca aggttacttc ctttgtcagt 204901 gttaattcct ccagccaagt gccgtttttc ttcttttttc ctttatattg agagtacagc 204961 aagaataaca gcgtttctcc gagatcgaag aagtcatcct gttttcgtac ctttatttcc 205021 tccatttctt caggagtcaa ttgtttggca aggccgaaat cgatgaggca gagcctgcca 205081 tcattgatga tgatattagg cgttctgatg tcgctgtgga agataaggcg atcatgcagg 205141 tattctataa tctcaagcag ctgcgaaatc agttgtaacg ccataagctc tgtgaacggc 205201 tgttttcgaa aaaataataa ttcttctata ttctctccct caatgaactg catgacataa 205261 taagcctgtc cgtctatgat gaattcatct atgaagcccg gaatttgcgg gtggtgaatg 205321 tttttgagca gttttatttc ctgctggaat cggactttct ctttttcctt tttggctttt 205381 gtcggccgaa gctgttttaa gacataaggt gtttgagcta ggatatcggt gcacaaataa 205441 accaaaccgt agcctcccat accgaggcac tcttcgattt tgtattgatg atttaagata 205501 acgccgttct ttagagggcg gtcaaatagc agttttttta gaagttttaa tgccatgtct 205561 gcacttccct tggttgtact gactatagtt taccttctag acggagaata aaaaagagcc 205621 ggataaccgg ctcggtataa gttaaaactg ctttgtcacg tcgtattcat aatctatttt 205681 tgcttttacg ttgctcatcg tcgatctggc tgtcgctaat gtattatatt taaaactcca 205741 tacctttgcc acactgagtt gatccgacaa agagatatca taagaccctg aagtcgagct 205801 gtttacaagg gcacggctcc attcgttatt ttcgcttgtc atgatcagat ggcgtgtatt 205861 tccctggctt ggtgtttgag tggcggttgt ttgaactctg gttacaatgg catcacgcgg 205921 tatcccagat tggtttgtta aatcaacctt gatcacgctg gagtcagaac ctgaggggct 205981 aaggcttgta tttcctttat tttcagcaac gccgctgaat tggaacgttc cgctgcctga 206041 tttgattcgg tcttcaattg aaagcgtaaa gtacatgttt ccagtatagg tgcctcgtga 206101 cactttcaca tagaaggtat ccgtcgtgtt ttgggcgtct gcatttgcat aaataaaaga 206161 agaaaacgta ttagggttaa taacttctgt cccttgagaa acaggtattc tgttcttgtc 206221 ataaatttca attttcatcc ctgtatacgc gctctggtat gtactcctca tgtatacttt 206281 ttctccctta ttagccgtaa aagtgaaata ggcttcatct tgaccagctt ccagtattgt 206341 tgtatcgata tttttatatt tccaataacc gatcggcatt gcggtatcaa atgaattgtt 206401 tcctgtgata gcagtgactc cgacagctga tgccgaatac gtaaaggtag ataagacaga 206461 aagcataaca gcgaattgaa taagccattt tttcaccatg caaacaacct ccttttattt 206521 ccatcataca taataacgat ttaggtgtaa ataaatgttt tttgaggtta atatatacat 206581 tatattcgcc gataaaaaag aataagagag aatactcggg agggaattca atgcgtctga 206641 atcggcaatt tatccgcact cagctgattg cacagaacat attgagcaag aatgcgcctg 206701 ccaaacggga gaatgcgact gaaaatccag cggcagttct ggaaaaggca tatagcaggc 206761 ttaagtcaca atcttcaact gggggaatca atcagttcaa ttattctaaa accagcgtgt 206821 cgggaaacag cgggacgttc agcaaagtgt atcaatcagc gaatgatcga acagtgacag 206881 acacagggga agaaacagtg attcaatccc aaaaccccta tgaatctgag agtgatatca 206941 gaatcaaaat actagatgaa aaatacagca ggatgaatgc gattaataaa acaaagtctg 207001 atccattagg ctatattaag gataagtacc aaaattcaaa gtctccttat ttcagaagtg 207061 atctgtcagc tgcagaaaga caggccgctt acgataatga aacagaatgg ttattcaaag 207121 ggaaggcgca aaactataac cttcaggatg ctgtgtttcg gaatgtcaca tttcatgggg 207181 aagtggaagc tgagaatgaa aaggtgtatc agcggggaca ggttaaccag cagctgcaag 207241 tactgttgaa tcgaaaccat attcatattc cagaggggac agagctgacg tttacaatca 207301 caccgattga ctatcaggtg cgggtaagcg ggacagacga tcaggatctg atcaagcaaa 207361 ttgagcaagt gctgcaatct ggagacaaca gcaaagaact atttttacac atcatgaaaa 207421 gtcaaagcag tgattcagca caattttccg aagaggccta taaaaagtat caggcagctc 207481 gtgagatgta tgaagttaca ggctaccatt tgaaggattt agaagtgatt gatgggcggt 207541 acgtcacgcc tgagggacgt gacttaatgg atgtatataa ggaagagctt gaaaaagatc 207601 cagtgcagaa acaaacggct tcttatgcta tatcttacta tcgttcagag ctcagtaaaa 207661 tcgcggaagc cgggtataat gccattccgg atttcatcct atcaattgat tacagcaatg 207721 gatctctgag agatgtggga caaagcaaga gctatgggac cggagatacc gggtggcttg 207781 aagcattaaa gcgtcaaacg ggtgtgaatt attaggtaag ctgttcatgt aggacagctt 207841 attttttatg agaatctaag gggtgaatta atcccaatat tcaaataatt ttattatttt 207901 tatataaaag attttaaaag aagtgaacga ttcaaaactc tgaacaaagg tgtttacctg 207961 aaaaaaacaa ttgtattttc cagagaaatt tattatgatg aaataagtaa tttaggagat 208021 tatataacaa ttttaagttt gaattttctg attgttatca ctgattcatg tgaaggcaag 208081 caggtctgct gttttctcat ttatgagtat tttgttagga ggaggaagag gagtggcaaa 208141 taaagaatta aagaggggcc tgggcgcgcg ccatattcag atgatcgcct tgggcggtac 208201 aatcggtgtt ggcttgttta tgggttctgc cagcacgatt tcatggactg gcccatctgt 208261 ccttctggct tatgcaatat gcggaatttt tatctttttt attatgcgtg cgatgggtga 208321 aatgctgtat gtcgagccga gcacaggttc ttttgcgacg ttcggccatc aatatattca 208381 tccgatggca ggttatataa cagcatggag caactggttc cagtggatta tcgtcggcat 208441 gtcagaaatt atcgctgtcg gttcttatac gaagtattgg ttcccggatt tgcctgcttg 208501 gatacctggt atcgtggcaa tggtgattct tggtgcggcg aatttaattt ctgttaagtc 208561 gtttggggaa tttgagtttt ggtttgcgat gattaaaatc gtgacgatta tcttgatgat 208621 tattgcggga atcggaatta ttttcttcgg ttttggcaat ggcggagatg cgatcggttt 208681 gtcgaacctg tggtctcacg ggggcttctt tgcaggaggt ttctcaggtt tcttctttgc 208741 actgtctctt gtcattgcag cctatcaagg agttgagctg atcgggatta cagcgggtga 208801 agcgaaggac ccgcaaaaca cgctaagaaa tgcgattcaa agtattatct ggcgtatttt 208861 gattttctac attggcgcta tttttgtgat cgtgacggtg tatccttggg atgagctcaa 208921 ctcactcgga agtccgtttg tgtctacgtt ctcgaaaatt ggaattacgg cagcggccgg 208981 cattattaac tttgtcgtga ttactgcggc aatgtccggc tgtaacagcg gtattttcag 209041 cgcgggccgc atgctgtata cactgggtgt caatggacaa gcaccgaaat tctttaagaa 209101 gatttcacgc aatggtgtgc cgctgtatgg cacaattgcg gtgctgatcg gtttggctgt 209161 cggcgttgta ctgaactata tcgcgccgcc gaagatcttt gtctatgtat acagcgcaag 209221 cgtgctccca gggatgattc cttggtttat cattttgatc agccatatcg gattcagaaa 209281 agcgaagggt gctgcattag ataaacatcc attcaaaatg ccgtttgctc cttttacaaa 209341 ctatttgacg attgctttct tgctgatggt tctggttggc atgtggttta acgatgatac 209401 tcgtatctcc ctgattgtag gcgtgatttt cttagcgctt gtggtcatta gttattatgt 209461 gtttgggatt ggcaaacgca cgcaggccaa tttgacaaaa agcgaacaag cagctgaata 209521 acgataaaaa agagacattc acggatgtct ctttttttat ttttcgcgta tggattttcc 209581 ctattttagc aagctatagg gtaaagatag cagaaggaaa ggtgttcata aaatggatgt 209641 tacactcggt tatttgcgcg aatcactttc gaatcatcta gaaaatgaag tctgccagcg 209701 tatttgcaag aagatgctgg cgaagcgtta tgcaaatgaa gaggaatttg taaaagactt 209761 agatgataat gaaatgtctt ttttgaacca tgtattagaa aaagaaatta agtatgccca 209821 gaatgaacag gatcaaaaac gggccaagga attaaacgag gtgtatgaat tactgctttg 209881 agaaaggcgg gtaagaaatg ggagcaattg aacgaagcgg atatacattt cagccggagt 209941 ttagcgttgt ccgtcaaaac ggagccatcc atgtgtacca tcaaggagaa tttgtggaag 210001 aaatcgaatt tgaatttaac ggggaatatc ccgatcatga tttgattgaa gagcttgtga 210061 atcattattg ttttgagcat gagatttaga gccctgccgt gcagggctct tttatttagg 210121 atgtaatcag gccatacttt ttcaggatat ccacggtgat gtttttggct tttgtgccgg 210181 aatcatcgac attggtgaca aagacataag agccatgctc tgttttgatg aatccgacaa 210241 accatcctaa tcccatatca gtcaggcggg ttccggtttt cccgtagagc gtgtaatgat 210301 cgccttcctc ttgaatcatc atgcgcttga cgattttcat caccggcttg tcaaatggaa 210361 gctcctcttt agccagtttc tccaaaaaag tttcttgttc cagcggagat attgtgagcg 210421 agctttgcag ccaaaactgg tcgattcccc cgctgatatc ctcgttgccg taagatagag 210481 tatgaagcca tgttttcatt ctttcctcgc cgatatctct cgctaatgcc tgataatacc 210541 agattgcgga ttcgcgcatg gccgagccaa gcgtatggtc gcggttccat gattcgaatt 210601 cacgcttgac cccgtcccat cgtttaacat cgtattcatc tcttacagct ttgacctgca 210661 aaccgattaa agcgttcacg actttaaagg tggattgcgg agtttgtctt tgatttgccc 210721 gttttctgtt atagacaaat gtctgatcct tttgtaaatc gtgaagaatg aaggttccat 210781 ccgtatcctt gaattcatca tcgacattca ttttgctgac attcaagtgt ttttcatgag 210841 cagatgatgc tgcgtggacg gagaagccgc cgatccctgc aatactcagc acaagcacaa 210901 catatatcca ttttttcatt ttgttctccc cttcgttttg attaactacc ttttctctct 210961 ttcgtttgtt cttcctttaa aaaataatca aaaagcgctt aaatttggtt ttgcaaacaa 211021 atactgttac tgggtttata gtcggaagat aacgtgaaaa tagagggtaa aaaggaaggc 211081 agggtaagcg gatgaatgag cagattccac atgacaaaag tctcgataac agtctgacac 211141 tgctgaagga agggtattta tttattaaaa acagaacaga gcgctacaat tcagatctgt 211201 ttcaggcccg tttgttggga aaaaacttta tttgcatgac tggcgctgag gcggcgaagg 211261 tgttttatga tacggatcga ttccagcggc agaacgcttt gcctaagcgg gtgcagaaat 211321 cgctgtttgg tgttaatgcg attcagggaa tggatggcag cgcgcatatc catcggaaga 211381 tgctttttct gtcattgatg acaccgccgc atcaaaaacg tttggctgag ttgatgacag 211441 aggagtggaa agcagcagtc acaagatggg agaaggcaga tgaggttgtg ttatttgaag 211501 aagcaaaaga aatcctgtgc cgggtagcgt gctattgggc aggtgttccg ttgaaggaaa 211561 cggaagtcaa agagagagcg gatgacttca ttgacatggt cgacgcgttc ggtgctgtgg 211621 gaccgcggca ttggaaagga agaagagcaa ggccgcgtgc ggaagagtgg attgaagtca 211681 tgattgaaga tgctcgtgcc ggcttgctga aaacgacttc cggaacagcg ctgcatgaaa 211741 tggcttttca cacacaagaa gatggaagcc agctggattc ccgcatggca gccattgagc 211801 tgattaatgt actgcggcct attgtcgcca tttcttactt tctggtgttt tcagctttgg 211861 cgcttcatga gcatccgaag tataaggaat ggctgcggtc tggaaacagc cgggaaagag 211921 aaatgtttgt gcaggaggtc cgcagatatt atccgttcgg cccgttttta ggggcgcttg 211981 tcaaaaaaga ttttgtatgg aataactgtg agtttaagaa gggcacatcg gtgctgcttg 212041 atttatatgg aacgaaccac gaccctcgtc tatgggatca tcccgatgaa ttccggccgg 212101 aacgatttgc ggagcgggaa gaaaatctgt ttgatatgat tcctcaaggc ggggggcacg 212161 ccgagaaagg ccaccgctgt ccaggggaag gcattacaat tgaagtcatg aaagcgagcc 212221 tggatttcct cgtccatcag attgaatacg atgttccgga acaatcactg cattacagtc 212281 tcgccagaat gccatcattg cctgaaagcg gcttcgtaat gagcggaatc agacgaaaaa 212341 gttaaattaa aaagctctct tcctttatcg aagagagctt tttgattact tctttttttc 212401 atcgtagtat tggacgggat acatggagcc ttctgatacc attttgttgt cctcgatatc 212461 ttgcgggtcc gggtggccgg ctttatcaac tgggaacgtt tccatgtctg gctgttttgt 212521 tattttcatc ttcatgctgt gaatgaattc tcttgccttt tggcgatttg acgggtcttt 212581 taatagataa gaagtgatgc cgacagttga aacagcgaga cctgaaagta acagcttttg 212641 tttcatggtg atactccttt ctattttaag aatagtgttt cctgtatcat tcccgttttg 212701 gaaattgcta aacctgttgt gtttttatca ttggaattaa cagtaaattc catttaagaa 212761 gaaactagtg acttcattcc tgtattggaa ggtaatatac attgacttat tatagatttc 212821 agtcaaaatt cgataaatat tgacaaagta aagtaatcag aataataata taattagcaa 212881 gagaatgtca tcatacatga aaggtgttta cgatatgaat caattgcatc gaagaatggg 212941 aacgttttcc ctcatgatgg tcgggctcgg gtcgatgatc ggttcaggct ggctgttcgg 213001 ggcttggcgt gcggctcaaa tagcaggacc agctgctatt atttcatggg ttattggaat 213061 ggtcgtcatt ttatttattg ctctttctta tagtgaacta ggttctatgt tccctgaagc 213121 ggggggaatg gtcaaataca cgcaatattc acacggttcg tttatcggtt ttattgcggg 213181 ctgggccaac tggattgcga ttgtgtccgt cattccggtt gaagcggtgg cctccgttca 213241 atatatgagt tcttggcctt gggaatgggc gaaatggaca agcggtttgg tgaagaatgg 213301 aacgctgact ggggaaggac tagcgtttgc ctctgtattg cttctcattt attttctgct 213361 gaactactgg acagtcaatc tattttcgaa agcgaattca ttaattacga tttttaaaat 213421 tattattccg ggtcttacga ttggagcttt gctgtttgtc ggattccacg gagaaaactt 213481 tactggcggt caaagcattg cgccgaatgg ctgggcaagt gtgctgacgg cggttgccac 213541 ttccggtatc gtttttgcgt ttaatggttt ccaaagcccg attaatatgg cgggtgaagc 213601 aaaaaatccg gggaaatcaa tcccgattgc ggttgttggc tctctttttg ttgcgacagt 213661 gatttatgtc ctgctgcaga tcgccttcat tggagctgtg aatccttctg atattgctca 213721 cggctggagc catctgaatt ttaattctcc ttttgctgat ctggcgattg cgctgaatat 213781 taactggctt gttattgtgt tatatgcaga tgcatttgta tcaccgtctg gaacggggat 213841 tacgtatacg gcgacaacgt cccgaatgat ttacggaatg gaaaaaaaca aatacatgcc 213901 gagtatattc gggaagcttc atccgattta cggcgttccg cgacaagcaa tgttctttaa 213961 cttgattgtt tcgttcatct ttttgttcct gttcagagga tggggcgtat tagcggaaat 214021 tatttctgtt gctacgttaa tttcttatat caccggcccg atcacagtga tgacattgag 214081 acggacgggg aaagacctgt acaggcctct tcgtttaaaa ggcttaaatg tgattgctcc 214141 gcttggattt atctttgcgt cactggtgct gtattgggcg cgctggccgt taacaggaca 214201 ggttctgttt attatcctga tcggtcttcc gatttatttc tattatcagg cgaaggcgaa 214261 atggaaaggg tttggccgga actttaaagc cggcgtctgg atggtgtttt atctgctggc 214321 catgatggtt atttcttatt tgggcagtga taaattcggc ggcctgaatg tcattcatta 214381 tggctgggat atggttctga ttgcgatggt atcccttgta ttctatgtgt gggcgctgaa 214441 gagcggctac cagacagaat acttaaagga tgcgaaagag ataaattctc agctgcttaa 214501 tggacagtca gaagctgctg ccggaaaaga ataaaatata gaagaaaacc ttgcgatagt 214561 tgtcgcaagg ttttttgctt ttaataaccc ttttttactt tgtggaaaag atcaggatag 214621 ttggtgaaca ctcctgttac gccccaatca agcaggcgat gcatatcagc ttcattattg 214681 actgtgtaag gatgaagcag gaggccgtgg ctgcggatca tacggacgtt ttcttgattt 214741 aaagctttat aatccgggcc cgcaccgaca gcgtatgttt tgatttcttc cagggcagca 214801 tctgtcattg acgccatttg tttggcttcc agcaattgaa cggtcggcag gtttggctgt 214861 aattgatgga cttttaccag gctttctttg ctgaacgatt gaatgatcac ctggcctggc 214921 ttagaatgct ttcccagtaa tttatgtttc tgcaaagaag cgatcagttt ttcttccata 214981 cctgggtagg tgtcaggcga ttttgtttca atgtagtagt tcgcgtgctt tccgaaacgg 215041 tctaatacct cttctaatgt aggaacttta aggccgacgt actgcggctt tgctttttcc 215101 ggataggctt cattaaacca agaaccggcg tcaagcttct taatgtctgc gagcgtatgg 215161 tctttcaccc aacccattcc gtttgtggtg cggtccagtt tttcgtcatg catgacaatc 215221 aattttccgt cttttgtcat ttgcagatcc aattcaataa aatcagcttt cattttctga 215281 gcggtttcgt aagacagaat cgtgtgctca ggcacatatc cagaagcccc tctgtgcgcg 215341 acggtcagga tacggtcagg tgacagcagg tttccttttg acgctgccga cactggcgtt 215401 accataaatg agagtaagcc cagcgacaga acaaacaagg ccagtattct attttttctc 215461 atgatttctc ctccttatag ataagcacta cctgtctttc ataataaaaa acggatgtaa 215521 acggcgtgtt ggaaaactat taatctttta tgtgtctttc ttaaacatgc tctgcccgtt 215581 ttcctgtatt ccacgtcaaa gccaagaaga cgatggcaag aatgcaggat gagatcagca 215641 tgataaagcc gccgttccag ttaaaacggt ccacgacaaa gcccataatg gcgtttgcga 215701 aggcggatcc gccgatgtat ccgaaaaatc cggtcaaacc ggctgcagtt ccggctgctt 215761 ttttcggtgc taggtcaatt gcttgaaggc cgatcagcat aacaggtccg tagattaaga 215821 agccaatgct gatcagggcg atattgtcca cgagcggatt gccggccgga ttcagccagt 215881 acaccaatac ggcaatgaaa acacccgcca taaacaaaac gcctgccggt gcccggcggc 215941 ttttgaagaa tcggtcactg atccagccgc acaagatcgt tcccggtatg cctgcgtatt 216001 cgtaaagaaa atacgaccag cgtgagtctt caggagaaaa gcctttggct tctgttaagt 216061 aagtaggcgc ccagtcaacc acgccgtatc gcacgaaata aacaaataca ttggcaaaag 216121 cgatgtacca aagaaatttg ttgttcagca catattgaaa aagaatttct tttgttgtta 216181 attctttttc ctgattttta aaagcgtgtt ttggatagtc attccgatac tcttcaattg 216241 gcgggagtcc gcaggattga ggcgtatcac gaaccaataa aacaattaaa aatgaaatga 216301 taatggcgat gatggcaggg aagaaaaaca cgcttttcca agtgacgaac atcgcgatcc 216361 caagagtgac aagcggagca agaataccgc cgcctatgtt atgggcgaca ttccagatcg 216421 acatttttgt gccgcgttca cttatggaga accaatgggc catcgtcctg ccgcatggcg 216481 gccagcccat tccttgaaac catccgttga taaacataaa aataaacatg atggtgacgc 216541 tcgaagtcac ccaaggcatt gaaacgaata gaatattaac gattgctgat aaaaataggc 216601 ctgtcgccag aaaatatctc ggattacagc ggtcagacac cattcccatg atgaatttgc 216661 tgaagccgta cgcaatggac acagcggcca gcaccaaacc cagttctgtt ttcgaaaatc 216721 cctgttcctg cagataagga atggcaaagg caaagttttt ccgcagcagg tagtagcctg 216781 cgtagccaat gaaaatacca atgaatactt gcagtctgag ccgtttgtat gccgcatcca 216841 tctttgaatc atccagtctc tcaatatgag gagccggttt aaatatatta agcattaata 216901 attatccccc tttgctgttt gtgctggatg tgtggcgtgc ctcctttccc gaaaaacaaa 216961 aagagccaga aaacacccct tgtcaaaagg ggttggattc ctggctctcc tcatctccat 217021 ccaagctatt aacttatcat gatagcgctt tcttaaatta tcatagtccg gagcgaatgt 217081 aaacgggtaa ttttcaaatt gggccttagg gaagtgaata ttatcctttt actaaatgca 217141 attatatttt tttactagta acataaaaat ctggagggag gctgtttaaa gatggatgaa 217201 ttagatatcg cattctttat tttaccgtta ggaattatgc tgctatcgat tgtcgggacc 217261 tgtatttgta aaaacccgta tctgatgcca atgcttagtt tggtgatttc tcttgtgctc 217321 acctttacca tttttaatca atcatttttg ggatgggctg ttgtctatag cttggtttct 217381 ctggctttat cctatatcac attgattgtg gtaaggaaaa ggaaggaatc aggaaattaa 217441 aaagacctca ctttctaaca tatcgttgac taaagcaact atatgtgatt ataattgctt 217501 tagtcaacga tattagaaag tgggaattga tttgaaaaca agagaatcat ctgtcgggtt 217561 aaaattcaga aagttcaatc gattttatac aaacgtcctt ggtttcctta atgagcacat 217621 ttacgacagc ccgttttcct taacagaaac acggatttta tttgagattt ataatacgcc 217681 taattgtacg gcaaaagctc ttcaggataa gctggggctt gaccggggat atgtcagcag 217741 gattgtgaag cagtttgaaa aagaagattt gatttataaa cagaggagca aagatgacgc 217801 ccgccaccat tacatttttg tcacagaaac aggaaaaacg atttataaaa agctggagga 217861 gaaagccaac gaacaagtag aactgatgct gaaggtaatc aaccaaaagg agcagcacaa 217921 gcttgccgag gcgatggcag agattgaagc gatcctttca cagtcgcttt ctgccagagc 217981 atcagagata tcgattagag attattttct ttcggaggat cttcaactcc ttattgagaa 218041 acaaagacaa ttttacgcgg aggctcacgg ttgggatgac acgtttttag cttatcttca 218101 ggagacattt gacgctgaca tcgaaaaaat atggattgcg gaaagcggcg ggaaatttgc 218161 cggctctgtc gggttggtca agcacgatga aaagacagtc cagctcagat ggtttctggt 218221 tgatgcggat tttcggggca gggggcttgg cacgcaattg ctggagcatc tggttgcata 218281 ctgccaagac atgaagtttg accgcatttt cctttggacg gtgagcacga tggctgaggc 218341 tcgtccgctc tataaaaaat ttggattcag gataagtgaa gtaaaacaag aagcgccatt 218401 atggggacag cagctgacag aagaacggtg ggatttggag ctgtcatgaa aagactgcat 218461 tatgcgtgga tcatcgtctc cgtcaccttt ttgatcttat tggcggttca gggggtgcgg 218521 ctgtcgtttg gtgcgtttgt ggagccgtgg gaacggcagt tttcaatcga tagaagcacc 218581 atctcgctga tttcgacggt gagttttatt gtttatggca tatcacagcc tgtgatcggt 218641 cggcttgtgg acaaatgggg tgcccgggct gttttggcat ggagtgcgtt actgacagga 218701 gtcagcattt tcttaacata ccttgtgact tcgccttggc agctgttttt gctttacggg 218761 ctgggtgtct cgcttggagt gggcggagca tcgaatgtgg cggcaagtgt attggtcgtc 218821 aattggttca gcaaaaagcg gggactagcc tttgggatca tggaagcagg ctttggcgcg 218881 gggcaaatgc ttctcgttcc cggctcactc atgttgatcc attggtttag ctggaagctg 218941 acggttgtgg tgttgggact gctgttaatc gtgattgtct ttccggctgc gctgctgatg 219001 ctgcggaaca atccttcaga aaagaataca gagccgatag gcggactggc tgcatcagaa 219061 aaagaaacag cacccaaaac aacagctctt tcagtggccg ggatgtttcg tatgaggcaa 219121 ttctggttct tgatttttcc gtttttgatc tgtggattta cgaccgtggg gctgatggat 219181 acccatttga ttccgttttc tcatgatcat ggcttttcaa cgacagtcac gagtgctgct 219241 gtcagtctgc tagcaggctt taatattgct gggatcttgc tgtccggaat tgtagcggac 219301 cggtggagca gccggaaaat cctgtgcatt ttatatgcgg tgcgggcgct gtcgatcgtg 219361 attcttattt acagccacga gccctacttg cttttagcct ttgcgattct gtttggatta 219421 gtggactttg caacggtagc accgactcaa atgctcgcca cccagtactt tcaaaactac 219481 tcgatcggcc tcatgattgg ctggctgtca ctcgcccatc agatcggatc ggcactaggt 219541 gcgtatgtgc ccggcgtcat ctacacggta acgggtgagt atacactggc tttttatttg 219601 tcgattggaa tgctcgtgct tgcgagcgta atgaatgtga tgctgaggga gccagctgcg 219661 gttacgcgtg acagtgcggc tgtggtagac aagtgatgag gacaaaggga aagcatctct 219721 gatttcgaga ttattcagag atgctttttt tgtatttttg ttctaatacg aagtcgatca 219781 taccgactat gcgggcgttt tcggattttt gtttgaagcg ttcagaaatt tgaacttttc 219841 ttgaaaatgg ggaaacaata aaaacccaaa aaaggccgat caaggcaaaa aacatttgta 219901 cagctaattc tattaattca ttaaaacgag tgctgaaaaa atagaagtat aacgttatta 219961 atgtcacagt acatacgatt ttggcaagtg tgtttgaatg taagcaatgg ttcactaaag 220021 aataccttta attgattcag catgattgaa tcatatttgt ttaggaaaat aagaagttct 220081 ttatcatctt ttttatgttc taaaataaag ttgctgtttc tgtttcttta tatgtatggt 220141 ggtctacatt caatatatac atctcttaaa gtataaaaat tgagtatttc ttagtaagga 220201 tgaaacaaaa ttacatgatt tttttgttat atctttcagt tagaataaaa tctataactc 220261 ctctcattcg caaatattcg gctctctgtg caaagtgcag aacagtatgt aattgtcctt 220321 ttctagatat atttaaaagc tttatcaaat caataaggat tttcaagaaa ataattaata 220381 atagaaagat aaaaatgtgt ggtatgtcaa tgtaattgat ttgtcctgaa aataaagaag 220441 ttgcatagac aacaataata cttccgcaaa acatcaaact catataatgt ggaagggaaa 220501 atggacgagt tgaaaaatat gcttttaatt ggcttagcat agcattatct cttgtatcta 220561 agtagcccaa aagctcttta tcatttttac taattgtaag aacatgattc aatacagcac 220621 taaaattcat tgaatcttca ttatcagagg cagtatgttt attagcctgt atgttttgtt 220681 gatccatttt atatttttta taaagtattg tattaattaa cttgtttttc tcatagaatt 220741 cagatcgttg attaagggat gcttttcctt tgtttttatt tccttttttt atgattttag 220801 tataagtcat aaaaatacaa atgactgtaa aaatagaaaa cactgcaggt gaaatatctg 220861 aaagaatagt attggtgaag acttcttttg cttggatgaa aaggaaagaa gctaaagtca 220921 tagatataaa catgcataaa actgctactt tcacaagaaa ctgaagcgga agagaaggtt 220981 ccgaataata gtgcttcaac tggttgagtg tcagagaatc ttggcgaaaa agataatcta 221041 ttatctcctg ctgattttgc atctgattga tatcatgagc gatgtttttt gttttttcaa 221101 aaactatttg atcatttttc atttttgata aacctccaaa agacgataga taaactaaaa 221161 aaactgcatg agcatatttt aacttatgtt catgcagttt tgtattaaag ttagctagta 221221 taataagcaa aaatggccag taacatagca gataatgcgg tagcgacttt gactccttta 221281 ttgttcgtta aatcactgcc catattccca attagtaaaa gtgcagcaac acctacaaca 221341 gggaataaat attgatcata agacggccaa tctaacgcta attcactctc gggagacgta 221401 actggtactc ccttgtacgt ctttatttta aacgtaatcg tagtcgttag tccagttgtg 221461 acattgtcac cgactggaat atcaggtgta tagattttaa tttgaatgtt taaagattca 221521 gctgttggat ttacataaac ctccaaataa ccgttgcgta ctgataagct cagactattt 221581 aaaaggtttt gataagagtc gatttgtgac gcagtgagag acgtttgagt gtcgcccaat 221641 aaacccgtga tataggcacc tggtttacca tttgtaatgg taattgtgtt tggtgaacct 221701 tcacttggta tggttgccag aagtgaagtt gatagaataa tatccaactc aggtgatgtg 221761 aaaatggttt ctgtcgtatc aaattcaaac atcgcgtttg ccagacttgt tagattttct 221821 aaagctggaa tggtagataa aatgtctgtc agtgtacgca gtcttgcatc atataccgga 221881 tcagacggcg gatttacatt gcttgcacct gagtctcttc ctgaataccc gtctttatca 221941 atcccgatgc ttccagagcc gcttccgatg gttccttcat aaaattgatc aaaggcccag 222001 ttgtttggca tcggatagcc gagattgccg ctaaatcctg ttgacatatt tgccacaaaa 222061 ctatactttg tcagtcctgc ttcagatgta cggatacaaa tgtttcttgg tccgtaaacc 222121 cctatttcat acttaggtgc ggttgaaaat gtctgcattt ttgtaaatgc tgacttaatc 222181 tcttggaaat aaggaatgat tttatcggtc acttcataat cgtatgcatc aaaatcgaca 222241 gcgaaataaa tggtcgtgcc tgacggaaaa cctaatcttc tagcagcaga agcggcacta 222301 tatgcatctc ttgtgccttg gtctttgaca aaataagaag attcatagcc gccgtcttga 222361 taaattggga aaaccttcaa tccggcatca agaataactg caagctcttt agatgtcagg 222421 gctttagatg tgaggccgct gcttgtccgc acatttccgg tcaaatatct gccaaccgtt 222481 ttataaccgt tattccgcag tgtttgagct ttttctgcgg ttataattgt agcagtgtca 222541 caagcagaag cggtgcgagt tgtgtctcct gagcttgata ataaagcttt aatggttggc 222601 atatctgcat aacctgtttg cggcaggcac atgaactctt gaaatgcttt aacagctgaa 222661 acaacaccca caccatattt gccgtcaaac tcaccaggat cgaacgattt tccgttacaa 222721 tagagggcgt actgaacaat taagacaaat cctgttcttg aatcgccggg agttaaagta 222781 gggcacaaac ttgtggtgcc gtttccgaaa aatccattgg caacacttgt gctcatgcct 222841 tcttcttttt gcagggcata aataagagct ttatttgtat cgcggccata cagtccgtca 222901 caaggcatta acccgatata gtcattgtag tctcgattta agttttgttg aatctggcga 222961 attcttgaat cacccccaga caccagctta aaagcgctca tgtctaataa ggctttcata 223021 attaacgtgg tgacaatccc atcctgtgtt gtcagtccgg cagctttttg aaattctttt 223081 accgcatttt ctgttttttc gtaaaagacg cctgtaaaac cgccgggatt aaagccttta 223141 caccataaag ccccttgtaa aataaaattc atgttgcttg gttttgaatc tggagcttgg 223201 cgtttaagag gcttaaataa gcgctgtgtt gtcggcccga agttatcggc tggctctgag 223261 atacccaatt caatttgaag cgcccgagtc agaccgtaga tcgtatccca cccagttttc 223321 ccgctttctt caactgggtt atacccatgt ttgccgctgt acgtatcgtt cagccattgc 223381 tgtgtgatta agaccatttc atcaaccatt tcgattcctc ctttgttaga ttgcgttcat 223441 ttataggtgg caaacgtagg acaaaataaa aaaatggatg ccgttaagca tccattttac 223501 atccgttctc caacagcttc gctttcggtt tcagctctga aatgtagagg cctaaaagtg 223561 taagcgcgcc tcctagaaga gcgatccatg tcatgttttc gtgcagaatc aggacagaag 223621 cggcgatcgt gataaccggg accatgtaaa tatacgcact ggatttgacg gctccgagca 223681 ctccaactga ataattccaa gtggcgaagc acagggcaga agcgccaatc cctaagaaaa 223741 gcatgttgag tatatttgaa gcagatgaaa atcggcttag gtcaaaatgg aagtcgaaca 223801 aaaataaagc gggaaccata aacaataaac catacaaaaa tactctctgt gtcagctcga 223861 tgatgtggta ttcgtaggcg cttaattttt tcatgaatat cgagtatccg ccaaacacga 223921 gagcagcccc ggctgccatg atgtctccga gcggatttag acgcagtacc acattgccgt 223981 taaacgtaat caataaaagc ccgatcagtg ccgagataaa tccaatcaaa aaagtcagac 224041 gcaatttttc gccttcgagc agaaaatggg ccaaaaccgc agtgatcatc ggtataatgg 224101 acacgatcat gccgacattg gaggcgtatg tataggtgag agctatattt tctaatagaa 224161 agtataaggt tacgccaaat aaaccagctc cggcaaacaa cagctcctgc cgccaatttc 224221 tgaacggaat catgttggga cggacgagga taagagcgat aaagcccatc aaaaaccgat 224281 aaaataatat ttccattgga gagaagtcag ccagcagaac ttttgtcgaa ataaaggtcg 224341 tcccccaaat cagaatggtc acaatggctg cgatatgccc cgaagtttct ctttgtatgt 224401 tcatctgtga agctcctttt caaaaatctt catgtattgc ttcggcgtca gccccacctg 224461 ccgtttaaaa aacttcgtca tatgactctg atcgctgaat cctgtctgaa atgccgcatc 224521 aatcggcctt accccttgtt caaggagttt tttggcttga ttaatccgga ttgtttccat 224581 gtagctatta ggggtaatgc ctttttgttt tgtaaatgaa cgcaataaat gatacttgct 224641 ccagcctgtt aattcactca aatcattgag tgtaacattt tcggcataat gctcttctaa 224701 aaattcacaa accattttga cttcgtctga tggttctgga acgctgctaa ggaacgtgac 224761 atctgaataa tggcggatca gctcctctaa tagatgaaga aacagctcct ccttacgcaa 224821 agcttgtttt tcctcggata tcaaaatatg caattcctgc aggctggctg tcagctcatg 224881 gcggaataac acatgctggg agaaataagg gagatgcccg gagccagtaa tctctttcac 224941 cgccttctcc atgatatccg gcatgacatt gatacaccga taatcaagcg tccggccgtc 225001 aatctgttca cagctatgcg tgtcacgggg gttaaagagg agaagatcac ctggattgat 225061 gatatattct tgatcctgac aggccagata ccgttgccct ttttcaataa atccaatcac 225121 ataataatcg tgaaagtggt tcgggaactt ctgcataatt cccttgaagc ggtaggcttc 225181 tatatgaagg tgtgggtcaa gctgcagtgt gcgggtttcg ttttgcatgg gatgcctcct 225241 gtcggtgtgg tggtcttgga ttaagtgtag catgattttg ggggatttct tgtatgatgt 225301 tgctgtttag gaatagagaa agcagaccgt tatttgtctg ctttcgttta agaatttaaa 225361 agattttaac cctcaataat aattttatct tttttaataa aaatttattt ttcaaatatt 225421 tcagttataa tggtttggaa cagataggag gggcaaagat gtatcaatca aagaaggttt 225481 tattgttagg ttcaggtgaa ttaggtaaag aggtagtgat tgaagcccag cgtcttgggg 225541 tacagacggt ggcagttgac agttacgagc atgctccggc gatgcaggtc gcgcataaca 225601 gttatgtcgt tgatatgctg gacccagagc agatcagaac catcattgag aaagaaaatc 225661 cggatttgat tgtgcctgag gttgaggcga ttgcgacgga tgaattgctg aagcttgaag 225721 aggaaggatt tcacgttatc ccgaatgccc gtgcggccaa gctgacgatg gatcgggaag 225781 gcatcagacg acttgcggcg gaaacgcttg gacttgcgac agctggctat gaatttgcga 225841 atacatatga tgaatttata caagcggcag ctcagatcgg ttttccttgt gtcgttaaac 225901 cattgatgag ttcttctgga aaaggccaaa gtgtgtgccg ctctgaagcg gatttagaga 225961 gctgctggga gacggcgatg gaaggcggac gggtgaaaaa cggccgcgtg atcgttgagg 226021 agtttatccc tttcgaatca gaaatcacac tcttaaccgt acgtgcggtt aacggtacgg 226081 cattttgtga gccgatcggt catgtgcaaa aggacgggga ttatatcgaa tcgtggcagc 226141 cgcatgatat gacagagcag caaatagaag aagcgaagca tattgcgaaa acgatcacgg 226201 atgagcttgg cggatacggc ctgtttggtg ttgagctgtt ccttgcgaaa gatagggtat 226261 atttcagtga ggtatctcct cgtccgcatg atacgggtct tgtcacgctg gtgacgcaaa 226321 atttgtcaga atttgcgctg catgtccggg cgattctcgg ctttccgatt acagaaatca 226381 cacagctttc tcctggcgcc agcaggcccc tcaaagcgcc ggaagaatta gcggattaca 226441 ctgttgaagg attggaaaac gcactggcag tcccaaagac tcaagtgcgc gtctttggaa 226501 agccgataac aaaagccgga cgtcgtatgg cagttgcgct ttctgctgct gattcagttg 226561 aaacggcaag agagaatgca aagaaagcgt tggaccagct aattttaaaa tagagtttga 226621 acaggtcttg tcatgggaca aggcctgttt ttttctttct ccgtaaaagt tttatcataa 226681 gaatcagaaa cctgattata atgtaaaagt cttccatcga tacgggtggt tgacactaaa 226741 ggagggagat gacaaaatga aattagttcc aagattcaga aaacaatggt tcgcttactt 226801 aacggttttg tgtttggctt tggcagcagc ggtttctttt ggcgtaccgg caaaagcggc 226861 agagaacccg caaacttctg tatcgaatac cggtaaagaa gctgatgcta cgaaaaacca 226921 aacgtcaaaa gcagatcagg tttccgcccc ttatgaggga accggaaaaa caagtaaatc 226981 gttatacggc ggccaaacgg aactggaaaa aaacattcaa accttacagc cttcgagcat 227041 tatcggaact gatgaacgca ccagaatctc cagcacgaca tcttttccat atagagcaac 227101 cgttcaactg tcaatcaagt atcccaacac ttcaagcact tatggatgta ccggattttt 227161 agtcaatcca aatacagtcg tcacggctgg acattgtgtg tacagccagg atcatggatg 227221 ggcttcgacg ataaccgccg cgccgggccg caatggttcg tcatatccgt acggtactta 227281 ttcaggcacg atgttttact ccgtcaaagg atggacggaa agcaaagaca ccaactatga 227341 ttacggagct attaaattaa acggttctcc tggaaacacg gttggctggt acggctaccg 227401 gactacaaac agcagcagtc ccgtgggcct ttcctcgtca gtgacaggat tcccatgtga 227461 caaaaccttt ggcacgatgt ggtctgatac aaagccgatt cgctccgctg aaacgtataa 227521 gctgacctat acaaccgata cgtacggctg ccaaagcggc tcgcctgttt atcgaaacta 227581 cagtgataca gggcagacag ctattgccat tcacacgaac ggaggatcgt catataactt 227641 gggaacaagg gtgacgaacg atgtattcaa caatattcaa tattgggcaa atcaataaat 227701 acagcaaact agccatattc atgtctattt tgtttttatg cgggtgcagt tcgcagacgc 227761 attcttctca aaaagaaacg actattcctg tcactcttca tgtggaggat gctaaggggc 227821 tgccggtcga aggggttcaa gtgacgattg tcaaagcgcc ctcttcagat gaggagccga 227881 gtacagagat tggcgagata ctcggtaaaa cagacaaaaa cggagatatc aaatgggata 227941 ccggcagaaa aggcgattac tcagtcgcgt tgacgaaggg tgaaacatca gtaacccatc 228001 acatctcgtt aacagaggat aaaaaagatc atgccattcc attagtcttc aaagaatagc 228061 agtttccttg attttaaggg aactgccttt tttatttatt gcaggaaacc aaactatata 228121 ctggaaattt attatgtgag ataataagaa ataggtattt tttcttacga gacaaaaggg 228181 gcgttatcct ttatatcaat caaacccgga ggaaaaagaa gaagatgata caagattcaa 228241 tgcagtttgc cgcggttgaa agtggtctgc gcttttacca ggcatatgat caaagccttt 228301 ctttgtggcc gattgagtcg gaagcattct atgtttctac tcgttttgga aaaacacata 228361 tcattgcaag tgggccaaag gacgcacctt cgctcatttt gcttcacgga ggccttttca 228421 gctctgcgat gtggtatccg aatatcgcag cgtggagcag tcaatttcgt acatatgcgg 228481 tcgatataat aggagacaaa aataaaagta taccatcagc agccatggaa acgagagctg 228541 attttgcaga atggatgaaa gatgtctttg attctcttgg acttgagacg gcacatctgg 228601 ccggcctttc gcttggcggg tcccatatcg tgaatttctt actccgcgcg cctgaaagag 228661 tagagcgggc ggttgttatc agtcccgctg aagcgtttat ttcatttcat ccggatgtct 228721 ataaatacgc tgcagagctt acaggggcaa gaggagctga atcatatatc aagtggatca 228781 caggcgacag ttatgatctg catcctttac tgcaaagaca aattgtggcg ggcgtggaat 228841 ggcaggatga gcaaaggagc ctgaagccga cagaaaacgg ctttccgtac gtgttcacag 228901 accaggaatt gaaatcaata caagtcccgg tacttctgat gttcggtgag cacgaggcta 228961 tgtaccatca gcaaatggcc tttgagcggg cttcggtatt ggtgccggga attcaggctg 229021 aaatcgtaaa gaacgccgga catctgttat ctctggagca gccagagtac gtcaatcaac 229081 gcgtcttgtc ctttttatgc ggggggataa aatagtaagg aacatgaaaa gattggcatt 229141 catttttcaa aaggtaacaa atgttgtata ataatagaat ttgaatgctg ctttttttgg 229201 gagcattcta tgttatcatg cttattggag aaaaattttt cctgtaacgc tattcgatca 229261 ctatcgtcaa ataatataga tggttttaca attggaggtt tggttacact gtgaattaca 229321 tcccctgtat gattacgata ggaaacttca tttgcggatt gctggcgatt cattccttgc 229381 tatatcacaa cattcattca gcagtgcttt ttatttttac aggcatgttc cttgatttct 229441 ttgacgggat ggctgctcgt aagctgaatg ccgtttctga tatggggaga gaactggatt 229501 cgtttgccga tctggttacg tttggggtgg ctccttctat gcttgcttac agtgtcgcgt 229561 tgtataccct gccatttatc gggatcttat gcgcattgac gtacagcatt tgcggaatgc 229621 ttcgcctctc taaatttaac attgaacaaa gcaagctccc gacgtttatc ggtatgccga 229681 ttccgtttgc gggcatgtgt ctcgttattc taagcttcac ctataacccg atccttctgg 229741 caatcggcac ttgcggactc tcatatttga tggtgagtaa aataaaattc cctcatttta 229801 aaaaacatgc ggcagaaaac ctggagtctg ggagatggaa ttagttcagc agctcatagc 229861 ggattacggt tatctcgcta tttttttgat gctggtatta ggaattgtag gattgccgat 229921 tccagatgaa gtgatgatga ccgttgttgg ctatttcacg cataccgatg tattgaatta 229981 tgagctttcg atattgatta gttttgtcgg ggctttgtta ggtatgctga tcagctacat 230041 gattggcaga aaagccggac gcccgtttat cgacaagtac ggcaagtggg tcggcttaaa 230101 agaaaaaaga atgatgaaag tggaaaaatg gatgaagaaa tacggtccat attctcttat 230161 tttaggttat tttattcccg gcgtcagaca tgtgacgtgc tacttttcgg ggatcggcaa 230221 aatggatctg aaaacgtatg ttgcgtttgc tgcaatcggc gcctttttat ggtgctttgt 230281 ttttattaca atcggaaggg ttatagggat tattcatgtt taatacggct gtaaagattc 230341 tgtatcgatc attgatagag ctgacgaatc atcgtctgtc atcctatctg attaaaggat 230401 tttgcgagtc gaaaatcagc aaaccggtca ttccgctttt ctcaaaacat tttcggctga 230461 attgggatga tgtggacggt acggctgctg attacggatc gctgtccgaa ttgttcattc 230521 gacaaataaa tctggagcgg cgccctgtgt caaaagaggc gcatgcggtg gtcagccctg 230581 ttgacggtgt ggttcagacg gtaggaatca tcaacccgaa tcaaaccttt acggtgaagg 230641 gaaaagatta ctcattcgct gagctgaccg gctgtaaaag cgcagaccat caatacaacg 230701 gcggatattt cgtcgtgctg tatttaagcc cgaggcatta tcaccgtttc cattctccga 230761 tcagctgcag gtatcaaaag ctggccgagc tcggaaatcg ctcatacccg gtaaatcaac 230821 taggcttaaa atacgggaaa gatgtgctgt cgaaaaatta tcggtttgtg tacgagctga 230881 atagcggcag ccgaaatgtc ctgatgattc ctgtcggcgc gatgaatatt aattctatcg 230941 tgcagacgaa tacccgtact gaattggaga tcggcgagga gctgggatac ttttcatttg 231001 gctcaaccgt cattttggtt tttgaaaaag acgcgttcca gccgtccgcc catttagcag 231061 aaggccaaga agtccaagtc ggagaactga taggttacga agaataaaaa gaggagcttg 231121 cataaacgca gcgcctcttt ttttgaagaa aggtgagatt catggagaaa caaatcatca 231181 gctggattac agattatcag aacaccggag atgaagccgt cctgcggcaa gtgcgagaag 231241 tgtgctggcc gatcgttgaa gcggttttgc aagagaaagt aatggatgat gaacaagcga 231301 acaatttgcg cgaaaaagga atcgagcggt ttccattcat catcagcaaa taccaagcgg 231361 atgtgcagct tccggttgag acatttttac aaaatacgta tcggttttac tttcatcagg 231421 tgatgagaga atccagctaa agcttctttc aacagagaag cttttttttg ttggcaggaa 231481 aaggaaactt tttctatatc tatctcgtaa tgactagaga acctagcaga aaaggagaga 231541 tagaattgaa acgaatgata gtgagaatga ccctgccgct gctgatcgtt tgtctggcgt 231601 tttcttcttt ttcagcctca gcccgtgctg cttctgaaga aaaatattgg gatcactgga 231661 ttgaacgaca tgcacagcct ctggatgctt ccaatgcttc aaacaaagac cttcgatttc 231721 taaaaaaggt gctgaaggga aaacgaatcg ttcagttagg agaaaccaca cacggtgctg 231781 gcgaaatcaa tgccacaaag gtcagaatga tcaaatacct ccacgaagag ctgggatacg 231841 atgtattggc ctttgaatcc ggctttcctg atacaaatgc atcctacctt aatatggacc 231901 aattaacccc taaaagcacg atgaaaaact ccatttacgc tgtatggcac acagaagatg 231961 tcgtcgaatt gtttgattac atgaaagagc aaaaagagaa aggcgatccg ctgatcctta 232021 ccggttttga tattcaaagc atgaagaatt cattcaatgt agctgcgact caatgggtaa 232081 aagcggtgga ccctgagaaa gcagagttgc tctcccaatc agaaaatgat ttttcaacat 232141 tagtgacaga cagcaatacg tttgatgaat tttcgcaaaa gaaggaaaag cttgtgaaaa 232201 actatcagaa gctgatcaag ttcactaaaa cacatgcttc agagctaaaa gaaaaccttc 232261 caaaagagcc gaaagcttat gagatgttta tgcattctct tcagctgaga attgacgtaa 232321 tggaaacata tatgctggaa gaaatgaaag aaaaactaga ggagtatccg gagaatattg 232381 aggatttttc attctttatg agagaccgca tgatggctga acaatttcag tgggtagccg 232441 acacccttta tccgaaaaag aaaatcattg tctggggcca caattaccat ctacgcaaac 232501 agaatacgaa gatgataaag gactgggtac agctaaacgg ccctaacatg ggtgattatt 232561 tgccggagcg gctgaaaaaa caaacatata cgattggcat ttatgcttac tcaggtgcga 232621 gtcttgatag ctccgataat aagactgtta agccggttac aagcccgccg ccgtctggga 232681 gccttgaagc tttgctgaaa gcggcggacc gaccggctgt ttttgttgat tttctccata 232741 caaaaaacaa gaaaggcact tcgtggatgt ataccccgcg gactgcgctc tattgggggt 232801 acatggaaga gcagatgatc ctgaaggaac aatatgacgg tgtcatttgg ctggagcata 232861 tcacgccctc tgtcattatc aagtgagcgg tgtcccctgt ggtaaacagg ggatttttac 232921 atatcgcaaa aataatcaaa acatataatc cgtgatccat tattctaaaa cagaaaggag 232981 attggagcgt gcaatgtatt atgaaaaagc tgtccagaaa acaatcaatt ggattgaatc 233041 acatttacat gagcaaatat caaacgagga tattgttaac gtttcaagct tttcaaaatt 233101 ccattttcat cggatttttc aaaaagaagt cggcatgtcg gttgcttctt atattcggtt 233161 aagacgtctt gcgaatgcgg cggcagcttt gctttataca gatcatcgta ttatcgatat 233221 tgctttgtat tatcagtttg aatctcaaga agcatttacg aggacgttca aaaagatgta 233281 tcacatgccg ccaggagcat accgaacatt tatgaaacgc tttacttcaa aaaaggagga 233341 atcttacatg gagaaaaaaa tgaaaggctg ggtattgagc gggagccatc cgttccaatt 233401 cgaaatgggg attgaccggg aaaatgtaca tcagggaaaa gcttcagggt atttaaagtc 233461 aacgatggtt caggatatcg gtgaatttgc gacgatgatg cagcaattca aagcagatcg 233521 ctatctagga aaaaggcttc gtctatcaag ttttatcaaa acaaaggggg tgcagcattt 233581 tgcctcactt tggatgcggg ttgacagtgc tgctgatgat gttctccaat ttgataatat 233641 gagcaacaga cctattaccg gaacaaccaa ttggaatcat tatgctatcg ttttagatgt 233701 cccagaaaat agcgctgtga tatcttttgg cgttcaatta tctgggccgg gtcaggtgtg 233761 gatggatcat gttgtttttg aagaggtaga tgagagcgtt ccttcaacaa accttgaaat 233821 gccgggagaa cttttagatg aaccggtaaa tttatctttt gaagaggaac tacaaaaata 233881 gttttcagac aactactttt attagtgagt taatggaaaa tactatttgt tattaataaa 233941 cccttgtgct gcttaggttt gtaagagctt ggatattttt atcagtctgg gcggatctgt 234001 tcatctttgc ggcattttcc tgtatgatat agtaagagtg tgcatagcaa ctaactataa 234061 ttgaacaggg tgtttaaaac atggaaaaac aatacagagt attactttac tataaatatg 234121 ttccgattga agatccagag gcgtttagag agcagcatct ggctttttgt aaggagcttg 234181 gtttgttagg ccgtatcctt gtttcttctg aaggaattaa cggtacggta tcaggtacgg 234241 ttgaacagac tgaaaaatat atggaaacaa tgaaagctga tcctcgcttt gcggacatgg 234301 tatttaaaat tgatgaagca gaaggccatg ccttcaaaaa aatcttcgtc cgccataaaa 234361 aagagcttgt aacgcttcgt cttgaagatg atgtcgatcc gaacgaaaca acaggccagc 234421 atttgaagcc tgcagaattt tatgagaaga tgcaggatcc aaacacaatt gtcatcgacg 234481 cgcgtaacga ttacgagtat gaccttggcc atttcagagg tgcggtccgt cctgacatcg 234541 aagccttccg tgaattacct gaatggattg aagagcacaa agatatgctt gaaggcaaaa 234601 agattttaac gtactgtaca ggcggcgtgc gctgtgaaaa gttctcagga tggctggtga 234661 agcaaggctt tgaagatgta gctcagcttg atggcggaat cgtgacatac ggaaaagatc 234721 cagaggtgca aggcaagctt tgggacggcc agtgctacgt atttgatgaa agaatcagcg 234781 tgcctgtcaa ccgtgtcgag catgtgattg tcggcaagga ctactttaca ggagaaccgt 234841 gtgagcgtta tgtgaactgc gcaaatccat cttgcaataa aaaaatgata tgcacaccgg 234901 aaaatgagta taaatatatg cgcagctgca gccacgaatg ccgcacgaac ccaagaaacc 234961 tgtatgtgaa agagcataat atgacagaag aagaagtaaa cgcaagactg gcagcgattg 235021 aaacagaaga tcacgctgct gctgaataaa aaaagaacac ctcgtattga ggtgttcttt 235081 ttttctatat gctttcagtt tggctgtttg cggaaaccca ttctttttgg cggaaggcct 235141 tttcccattt tgataccacg atacaggcga tcgcatgtcc cggtacgttc acgcctgttc 235201 tcgccatgtc catgacgcgg tcaacacccg cgataatggc aacgccttca gccggcagtc 235261 ctacagcatt ggcagtcgcc agaagaacta caagcgatcc tgagggtaca gctgcaatgc 235321 ctttactggt catcacaagc acaagcatca tgagcagctg ctgggacaat gtcatgtcta 235381 cttgaaaggc ctgtgcgaga aagatacaag aaaccgataa atataagctg gagccgtcac 235441 agttcaatga caagccggag ggaacgacaa atgataccac tcgtttggga cagccgtatt 235501 tctccattct atccatcagc tgagggagaa tggtttcagt gcttgtggtg gaaaatgcaa 235561 ttaaaaacag atcccatatc attttcaata cttcgaaata cttaatctga aagatgagac 235621 cgacaagcgg aaagaggaca aagaggatca ggaacaggcc aaggaatacg gtgccaacca 235681 gcttaaacat agggaggagg agttcaatgc catattggcc tacagaagca gccatcaggg 235741 ctaacacgcc gataggagca gtgaccatga cgatttgcgt gagcttgaac ataatctgag 235801 ctgtagattc aaaaaacttc attactggtt cagaagcttt gccgatacca gctgcggcga 235861 caccaaataa aatggcgaag aaaataacgg caagcaaatc atttctggcc atgacatcaa 235921 taatgtttgt agggataata tccaggatca tttgcttgaa atcaacaact ttgtctgtgt 235981 agccggaaag ttcatgaata tctttttttg ccaaatggga gaggtcaagc ccgacacctg 236041 gttttaagac attcgctaat aaaagtccaa gccctaatac caacgttgta atcacttcga 236101 accaaatgat cgtcttgatg ccgagactgc ccattttttt catgcttccg cttcctgcgg 236161 ctccaatgac aatggtagaa aatacaatcg gcacaacaat cattttaatc aggcggataa 236221 atccatctcc gacaggcctc agtgccatcc cgaaatcagg aaaaaagtgg ccgatcaccg 236281 cgccgacagc caaagcgatt aaaatttgaa acgcgattaa ttttttcaaa tgaatccccc 236341 tttagaacga tagaatgtag gcatattcat atcattcgtg attcaaatgc aaacaccttt 236401 tttcaagtta ttttattttg acagcgcttt cattatgttg gcgaaaaagt cccccgcagc 236461 aggggggact tttttacttc atttgaatgt gctttagatc ttcttcagag gtatttgtga 236521 aaataaccgg tgttatggct gaagcggcat gctgcttgat gtaattgaga tcaaaggtga 236581 gaagcagttc gccttgtttg acggcttgtc cgcttgtgac atgtgcttca aagccttccc 236641 cattcagttt gacggtatcg atgccgacat gaatcaggat ttcagtgccg ccggcgctca 236701 taaagccgat ggcgtgtttt gtcggaaaaa tcgagacgat ctcgccgtcc gcaggtgcaa 236761 cgacttttcc ttctgatggt ataatcgcaa atccctcgcc catcattttt tctgaaaaga 236821 cctgatcagg cacatcccct aaagagactg tttctccttt aatcggataa ataaaggtct 236881 catcggaatc gggcttcagc ggtttgtcag ttaccgtgtc cagcgcggcg gcggtggcag 236941 ggacgcctcc ggccatgatt gttttgatgt cgtcttttaa ggcatcggac ttggttccga 237001 atattgcctg gaagttgttg ttgacctcca gcacacctac tgcaccaagc cgttttaatt 237061 catccttgca gacttggctt ggctgatgaa cggtcacacg aagccttgtg atacatgcat 237121 ccaggttagc gatattttgc tgtccgccca aggcctgcag cacgtgaaag gcaagctggt 237181 cttttgcaac tggagctttc tcctcattct gaccgtcttc atctgtctca cggccgggcg 237241 ttttcaaatt ccatttcaga atcgcaaatc ggaacaaata ataataaatg aaagcaaaca 237301 cgatcccgac aggaatgaca acccagccgt ttgtagacag tccgtagttc aagacgtagt 237361 caattcctcc gcctgagaac gtatagccgt ggcggacatg gaataaatca caaacgacaa 237421 agatgacgcc ggcaagaata gagttaatca aatagagcac gggcgcaacg aacaagaaag 237481 aaaactcaac cggttctgta attccggtca gcatagatgt gagcgccgca gaaatcatca 237541 cgccggagat catttttttc ttttccggac gcgcggtatg gataatggca agagcaacgg 237601 ccggcagaca gaaaatcatg taagggaaat cccccatcat aaagcgcccg gctgtcgggt 237661 ctcccgcgaa aaaccttgtc aggtcgccgg ttacggtgtt gcctgttgat gggtctgtgt 237721 attctcccat cataaaatag aaaggcgtat aaaaaatatg atgcaggcca aaaggaatca 237781 gcaaacgata gatcgttgca taaaagaaca ggccgactgt tgaatcggca attaaactgc 237841 tggctgcgtt aattccgttt tggatcagcg gccaaacgaa tgagaaaatg acgccgatca 237901 ccaatgaact gacggaagta atgatcggga caaagcgttt tccagagaaa aatccaagga 237961 ccggatgcag ctcgattgat gaaaatcgct tatataaata ggcggcgaga agcccgataa 238021 tgattcctcc gaaaaccccc atatcaatca ggtgctcggc tccttcatac ggaggctgaa 238081 ggccgagtaa ttttcccata ttgtcgaggg tgacggttaa aattaagtat ccgatgacag 238141 cggcaagtcc ggctacacct tctccgccgg ctaatccgat cgcgaccccc acggcgaaaa 238201 tcagcggaag gttatcgaat acaacgccgc ccgcatcctt tataataggg atgttcagta 238261 aatccttgtc tccgaaacgg agcaaaagac ctgctgccgg caggacggca accggagtca 238321 tcaacgcgcg gccaagctgc tgcagaattt gaaatgcctt tttaaacatg acagtctcct 238381 tttattgtgt tatgagaatg atgcactctt taatttttga gctgctttat aatcggcgat 238441 aacggttaca tgattgtgtt tttgaagaat ggaggctggt acatctgtcg tgacaggacc 238501 ttcagccatc ttttgaatgg cgtctgcttt ttcctcgccg cttgctaaaa gcacaatatg 238561 tttgctgaat tccatgatgg ttttaatgcc cattgaaatc gcgagtctcg gaaccagcac 238621 cggatcgccg ccgaagaatc tggcatttgc ctgtatcgtg ctttccgaga gcttcacaac 238681 acgtgtccgg tcttcaaaat cagatcccgg ttcattaaaa ccgatatggc cattggcgcc 238741 gatgccgaga atttggacat caatgcctcc cgcctggcgg atgagatcct cgtatacttt 238801 gcatgccgcc tcaagctgcg gattgtctcc ttgcgggata tgaatatgat caggctgcat 238861 attgatatgc tgaaaaagat gctcatgcat aaaatggtta taactttgcg gatgagatgg 238921 agagagacca gcatattcat ccaaattaaa tgtagtaacc tttgaaaaat caatttcgcc 238981 tgcctgatag tctgaaatca actgcttata caagccgacc ggtgtgcttc ctgttgccag 239041 gccgagaacg gcatctttct tagcttgtat ttgttcttta ataatggcag cgcttaactt 239101 acagagttct tcgtagtgct cggcgatcag aatcttcatg tgacaccccc tcaaagagat 239161 agacaagcac catatttgtt atgaccaatt tatgatactt gtcattacga atttagcacc 239221 gcccttatca aactgtcaat attaatttct gaaaatttgt tataaaagaa ggatacaaat 239281 ctttcatatt gggagggcaa atggtattat ggtctcaatg aaaaagaacg gattgcatac 239341 agaatgggga gaatgaaatg acagctttat attctgttat caagtttaaa atcattgagt 239401 taattaaatc gggcaaatat caggcgaatg atcagctgcc gacggagagt gagttttgcg 239461 aacaatatga tgtcagcaga acaactgtga gactggctct gcagcagcta gagcttgagg 239521 gatatattaa aagaattcaa ggaaaaggga catttgtatc ggcggccaaa atacaaacgc 239581 cgattccgca taagattacg agctttgcag aacaaatgag aggacttcgt tctgaatcaa 239641 aagtgcttga gcttgtggtg attcctgccg atcattccat cgccgagctt ttgaaaatga 239701 aagagaatga acctgtcaac aagcttgtca gagtcagata cgccgagggg gaacctttgc 239761 agtatcatac ctcatatatt ccctggaagg cggcaccggg gctggcgcag gaggaatgca 239821 ccggctcgct gtttgaattg ttaaggacaa aatacaatat tgaaatcagc aggggcacgg 239881 aatcgatcga accgatttta acggatgaaa cgatcagcgg acacttatta accaatgtcg 239941 gagcgcctgc gtttttatca gaatccctta cctatgataa aaatgaagaa gtggtggaat 240001 atgcgcaaat tattacacgg ggagaccgaa cgaaattcac cgtagaacag tcatatcatt 240061 cataaagcaa tgtgttttaa gaagggaatg gtggttctat gtttttattt acgaatggaa 240121 aagtgctgtg gggagcagtg attgctgcat tcatcctttc aattgtattt tacccttttc 240181 tgccgacgca gatgccgatt cattatgatg ttgcgaacag tccggatctg acggttaaca 240241 agctggcggg gactgtgatg ctgcctgttt tgatggtggt gtttgcatgg gcgcggaaga 240301 tcaattggca atttgtattc gcagtgtata ttttgctgat ttgccacatt gtcgtccttt 240361 gtttagcgct ctaaatcaaa cagccagaat aaaactggct gttttcttta atttcagctt 240421 catctgacaa tgaatgtggt gtataatagc tgatgatcct aaagaatatt ctgaaattta 240481 taggtgtgaa gcggcgtatt attaaaggaa aggctgtata ctttttgcag ctttaaaaag 240541 actgaatatt taaacaatta tgtgaaaggt gtgctgatta gattgaataa gcttattgaa 240601 cgagaaaaaa ctgtatatta taaggaaaag cccgacccgt cttccttggg gtttggacaa 240661 tattttacag attatatgtt tgtgatggac tacgaagagg ggattggatg gcatcatccg 240721 agaattgcgc cgtacgcacc gcttacgctt gatccgtctt catctgtttt tcattacggc 240781 caggctgttt ttgaaggatt aaaagcatac agaacagacg acggcagggt gctgctgttc 240841 cgtccggatc aaaatatcaa acggctgaac agatcgtgtg agcgcatgag catgccccct 240901 ttagacgaag agctggtgct tgaggcattg acgcaattag ttgagctgga gaaagattgg 240961 gttccaaagg aaaaaggaac gtcactgtat attcgtcctt ttgtcattgc cacagaaccg 241021 agtctcggtg tgaaggcatc caggagctat acatttatga tcgtgctttc gcctgtcggc 241081 tcctattatg gcgacgatca gctgaagccg gttagaatct atgtcgaaga tgagtatgtg 241141 agggcggtca acggaggagt cgggtttgca aaaacggctg gaaactatgc cgccagtctt 241201 caggcacagc ggaaagcgaa tgaactgggc tatgaccagg tactgtggct ggacgccatc 241261 gaaaagaaat atgtggaaga agtagggagc atgaacatct ttttcgtcat aaacggggaa 241321 gctgtcacac ctgctttaag cggaagcatt ttaagcgggg ttacacgtgc gtctgcgatt 241381 gaattgattc gaagctgggg cattccggtt cgtgaagaga gaatatcgat tgatgaggtg 241441 tatgcggcct ctgcacgcgg agaattgaca gaggtctttg gcacaggcac ggcagcagtc 241501 gttacgcctg tcggtgaact caacatccat ggaaaaacgg tgattgtagg cgacgggcaa 241561 atcggggacc tctcgaaaaa gctgtatgaa acgataacag atattcagct tggcaaggta 241621 aaaggcccgt ttaactggac agtggaagtg tgaaaatcga aaaagaacct gcccggaggc 241681 aggttctttt tattttgaat gagtcatatc agcagccggc tggcttttgc ggttttttac 241741 ataatatatt gcatagcaaa tggccataaa tggaacgccg caatagagtg cgattctttg 241801 attcggatca aaggcaatgc caacgacgga agccaggcat aacaggaacg cagcaatcgg 241861 cacgaacgga tacaaagggg ttctgtattt caaatcagta accttgtttc ccgcttcgat 241921 ataacgtttt ctgaacatga attgagaagc agcgattccc atccacacga caacgacggc 241981 aaaaccggaa atcgacacga gcacaacgta tacagtgtct ggcgcaaata cgctggacag 242041 caacgacaga atgccgccga tcatgctgaa caccagcgcg ttaaaagggg ttccttttga 242101 cgtcagcttt gcaaatgtcg gatgaagcgt tttttctttt gataaagacc acagcatccg 242161 ggaagaagcg tagagtccgg aattagccgc tgacaggatc gctgtcagga taacaaagtt 242221 catgatatcg gctgcgtatg gtacaccgac tctgtcaaag acagcgacaa acgggctttt 242281 gatgacacct gcatcttgaa tcggaatcag ccctgacagc acaaaaattg ttccgacaaa 242341 gaagagcgag agacgccaga ccgttgtttt tatcgctttt ggtatcgtct tgtcaggatc 242401 aacgctttca ccggctgcga ttccgattag ttccgttccc gaaaaggcaa aattgacgga 242461 cagcatcgtc atcaaaatcg ggacaaatcc attgggaaaa agcccgcctt ccgccgtgaa 242521 gttggacagc atcggagcgg cttctccgcc tttgatcggg atgatgccga acatggcaga 242581 gccgcctaaa agaataaata atacaatggc taatactttg atgctggaaa accaaaattc 242641 tgattcagcg aaaaacttga ccgaaaatgc gttaagcaag aagatgaaca gcgcaaagac 242701 ggcactccac atccaaaccg atgtatgggg gaaccagcgc tgcattaaca ggccggctgc 242761 tgtgaattct gatcccaatg ccacggtcca tgtcagccaa tacagccaag cgaccgtaaa 242821 tccggtgccc ggccctatgt atttggctgc ataggtgtga aaggcgccgg tcacaggcat 242881 ggcgactgac agctcaccga ggcatagcat gaccagatag acgatgccgg ccccgactaa 242941 gtaggcgagt atcgttccgg ccgggcctgc ttgctgaatg gtataacctg agcttaaaaa 243001 cagcccggtt ccgatgacac ctcccaagga aagcataaag aggtgccggc ttttcatact 243061 tctctgaaag gttgtctcat tcttgttgtg ggcagagttc atctttttcc aactttctat 243121 cagcgattta tttccttcct aataaaaaat ctcatgtcag aaagtgacac gagactccgg 243181 cgaaccggct ttaagttaga atatacaaac tattccgata agtcaagttg tttttaaaga 243241 gcgggcccaa gccgcaattt cttgaatatt ttcgggtttt gtccggcagc agccgccaat 243301 cagcctcgct cctttttcat gccaggtgcg ggcgctcgcc ccgtaagatt ctgcgcatgc 243361 tgcgccgttc cacgtttttg tttccggatc atattgctca cctgaattcg ggtagacaat 243421 gatcggtttt gacgtgttct tttttaactc ctctatcaag gaagggatat gctgaagcgg 243481 cgtgcagttg atgccgagtg ctgcaatttg gcggtgttca tcaagccacg atgcgcagtc 243541 agctgcaggt gttccgtcac tgatatgcaa gccgtcttta gcactgaagc tgatccatgc 243601 atacgtttca ggaaattcct tcaacagccg aacaatcgct ttggcttcag tcagacacgg 243661 aatcgtttcg catgccaata catcagctcc ggcttcaatc agcgccttca tccgggggcg 243721 atgaaattca atcagttcat cttctgatat tgcgtagttg ccgcgatact cagacccgtc 243781 tgcaagataa gcgccataag ggcctataga agccgcaatg atcggttttg gccgattcaa 243841 acggttctct tcaagcgacc aaaattcatc acgtgcttca gctgcgatgc tgacggacaa 243901 ctcgatgagc cggcgtgctt ccgcttcgct cagcccgcgt gcggcaaagc cttcaaatgt 243961 agactgatag ctggcggtga ttgcacaatc ggcgcctgcc gcaaaataat cagtatgaac 244021 ttgtttaatc agctccggct cttccatcag gatttttgcc gaccacagac tgtcattcaa 244081 attacagccc ttgcgttcaa gctcggtcgc catggcgccg tctagcacaa taagcgggta 244141 tgtatctaat atgtgttgga taggattcat agaatgtacc gatgccttct ttcagatttt 244201 tttgaaaaag atatgaaaat cgtaatggag gcttacgtgt ttgtcaataa acgcaaaaag 244261 agaaaggtgt tcagcccata tgtctgaaca cccttttctt atgatatttg tttgttgtgc 244321 gtgtcagtct ttgtgtctga aaccggccag cactcaatgc cattatggtt tttgagcaca 244381 tctttataaa agaccggatc cttgcctgct tttttctggc gtgtatagtc tttcagcgcc 244441 gtaaaaacga cctttgatag taagaaaatc gcgattaaat tcacgatgac catcaaaccc 244501 atgaacaaat cagcaagatc ccagacgagc tggactttgg caacacagcc aaacacgatc 244561 attgccagca cgccgatacg gtagacaaaa atcagttttt tgcttttgtt caaaaagccg 244621 atattggttt cgccataata atagtttcca attagagcac agaatccgaa taacaaaatc 244681 agaatcgcga gaaagcctga tgcccatgat ccgacatggg agctgaggga ggcttgtgtc 244741 aaggcgattc cgctcagacc cggagtatga taggcatccg aaaacagaat gataaaagcg 244801 gtgcttgtac aaatgaccag tgtatctgtc agtacaccaa aagcttggat cagcccctgt 244861 ttgacgggat ggcttgttgt ggcggtggca gcggcatttg gtgcgcttcc cattcccgct 244921 tcgtttgaaa agattccccg tctgacgcct tgcatgagtg ccgcgcccaa agccccgccg 244981 gcggcctggt caaaaccaaa cgcatttttc acgattagcg caagcacacc tggcagctgc 245041 gtaatgttgg agaaaatgac gaaaaacgca actccgatat acaggacagc caatacgacg 245101 acaatggatt cagccagctt tgcaatgcgc ttgactccgc caaaaataat cgtgccgaat 245161 acagcaatta aaatgagtcc caatgtcagg cggtttgtgc caaacgcgtt ttcaaaggca 245221 aggctgactg tattggattg aaccgagttg aagacgatac cgaacgataa ggtgattaac 245281 acagcgaaca gcgcgcccat ccaccttttg ttcagccctt tttccatgta atacgccggc 245341 ccgccgcgga agccgtttac atcttttact ttataaatct gagccagtgt gctttccaca 245401 aagctggatg ctgatccgat aatggcgata atccacatcc agaagattgc accgggcccg 245461 ccgagtgcaa tggcgatagc aatgcccgta atatttcccg ttccgacacg ggccgccatg 245521 ctgatgcaaa aggcttgaaa cggagaaatg ctgttttttg accgggaagc agcaccttct 245581 cttaataccc tgaccatttc tttcagcatg cgaacctgta aaaacttaag cctgaacgta 245641 aaatagattc caaaagaaag gagcaaaaca attaatagct ttgaccacaa aagatcattt 245701 gcaataccga cgatatgttc taggatttgc tgcatagaat cacctctttt ttcatgttta 245761 aaaaatgctg agctcccatt cctgcgccat atgcttcagc agcataccgc cagtgaggct 245821 gttgccgtat tcatcaatgg caggcccgta aatgccgatg ccgcatccgg attgaaaagg 245881 ctgttctctt ctggcgcttg gaggcaccag cgccatgatg ccgccggaga cgccgctttt 245941 ggccggcacg ccgacaaacg ccgcatattt gcctgaagcg ttgtacatgc cgcacgtcag 246001 cattaatgcc ttggccaatt ttgccacatc ttttggaatc acctgctcgt gtcgaatcgg 246061 atgatacccg tcatgagcaa ggatcaggcc gatcaacgca atatcttctg tagtgctctc 246121 catagcgcat tgcttcaagt acacctcaag tgtttcttct acttcagctt ctaaaaagtt 246181 tgtttctttt aaatagtagg ccagcgctct gttgcggtgg gcggtttccc attcagaacg 246241 gaatacttct tcatgaattc ttggccgttt tcctatcaaa gtttccatca ccgagtaaag 246301 aaactcgagc ttttcgtatg cagattctcc gggaaggatc gaagcgatgg tgagggcacc 246361 cgcgttgatc atgggattga agggctttcc cggcttgttg atttcgagcc gaatgattga 246421 attaaaggcg tcacctgtcg gctcgacatc tacgcggtca agcacatagg gaatgccgcg 246481 gctcatgcag gcggcaataa agctaatcac ttttgaaatg ctttgcatgg taaaagagac 246541 gttccagtcg ccggcgtgta tcatcgttcc atcaggctcc aatacacaga tgccgagctg 246601 tgaatcattg acttttccta aagcggggat atagtttgcg ctttgtccat tggcggcaaa 246661 agggcgatag tattcaaccc aatcatgaag ctgtaacgcc gggtttatgt ctttctggtg 246721 ctcttttatc aattctttca tcgaattcct cctcactgat ttttttctta aaggactgag 246781 gtgtatcaaa acgaaggcta agggggcgtt aaacgctttc ataatagcgg aaggtataat 246841 tactgtataa tggagactac agaatcatac aaaatacgac aaaaacattt tgaaaataag 246901 cagtaagatt tataaaaacc tcatgttctg ggtcaaaagc aatttgcagg ttttctcccg 246961 attccccaaa ataaaaagcg aggatgtgat caacataaaa ctggaacggt ttattgaaaa 247021 agacggatat atactggccc tcatgctgat tacggtgccg ctggccggtg aactgaaatt 247081 ttatcccctc aatgaagaat tccgggtcag ctttggggca ccggtttttt tcttcttttt 247141 atcattgttg cggcatgtgc ccgctgtgct gccgggtttt ctgactggag cggctgtttt 247201 catctttcgc gtctttctgg aattatgggg cggaggacac aatgggctga ctccgattct 247261 gtatgatcaa gcgtctggct ttttctttta tatgacttac gcctgtctgt tttccatatt 247321 aaaggccaat cgtttccgtg aacggccgat tatgctcggt ttcattgggt ttatgattga 247381 agttgtgtca gattgtgtcg agctaactgt gcaatttctc atttttcata cggttgtcac 247441 gcctgagaaa atcactgaca ttgcggtgat tgcgatttct cacacattta ttgtgatgag 247501 cttttatagt gtgctgaagc tgtatgaaac acaatcgaga gaaaaacaga caaggcagca 247561 gcacgagcac atgctgatga tcgtttccaa tttatatgaa gaaacggtgc acctaaaaaa 247621 gacattgaaa acgacagaga aagtgacaaa cgattcgtat cagctctatc gggaaatgaa 247681 gggcaaggat gttcagctga gcggcagaat cctgagactg gccggagaga ttcatgaagt 247741 gaaaaaggac aaccagcgga tattcgcagg gctttcaaaa ctgatttcga atgagagttt 247801 gagagattat atgagggctt ctgatttgct gcagctcgtg attcgaatga atgaaaagta 247861 cgctgaagca ctagggaagc agattgattt ttactgctcg atcgagggag agcatgacga 247921 atatcacgta tttatcgtgc tttcgatcat taataatcta acagcaaatg cggtagaggc 247981 tatggatgaa gagggaatgg tcagcctgag gctccgtaag ccaaatgaga gtatggtaga 248041 attccaggtg gaagacaatg gccccgggat ttccgagaaa atcggagaca ttgtgtttga 248101 cccgggcttt acttcaaaat atgacgaatt tggcacgcct tctacgggta tcggactttc 248161 ctacgtaaag gaaatcgtga cagagctaga aggggatatc acgtttgata atcagcagcg 248221 gggagtggtg tttgccatca ggctgcctgt ccggcatttg attcagaaag ggtgaaccaa 248281 aagctatgcg tttttttatt gcagatgatg accgtgcggt gcggtcaatt ttaaggcaga 248341 tcattgagga cgaagatctc ggggaagctg ctggtgaagc agacgacgga agccaagtgg 248401 aagggcatat gctgcaattt aagcagattg atattttatt aatcgatctg ttaatgcccg 248461 gaagagacgg cattgagacg attcgtcaga tccagaatac gtactccggc aaaatcgtaa 248521 tgatctctca agtggaggcg aaggaaatgg tcggggaagc gtactcgctc ggcatcgaat 248581 attttatcca taagccgatt aaccgcattg aaattgtcac ggttctccaa aaggtgaagg 248641 agcggatcga gcttgaacac tcgattggag ccattcagca ttctctaagc cggcttgtca 248701 atcggactga acggaaagcg cgtccccagc agaagagtga cagcggttta aaagaggcag 248761 gaacattcct gttgtccgag ctgggcatga tgggagaagg cggcgcacat gatctcatgg 248821 cggtcctgca gtatttagca gaacacgagc aatccgagcc gcacgaaaaa caaagccctt 248881 cgctaaaaca aatattcacc caagtagcgg tacggaagct ggggacagga gcctcacaga 248941 cggaagtcaa tcgcgaaatg aaagcctcgg agcagcgtat ccgcagagcg attattcatt 249001 cgctgcacca ttttgcttca ctgggcacaa ctgatttttc gaatccaaaa tttgaaacct 249061 atgcatcgaa attctttgat tttccggttg tcagccagaa aatgaaagaa ctccaatcca 249121 aggatgcaaa accccttgca cctgctagaa taaatatgaa aaaattcatc cacgtgtttt 249181 ttttggaagc aaagcttttg catgagacga tgaaacaaag aaggatataa accaaacagc 249241 cggctgacca ggctgttttt ttgctgcgca gaatcccggc cggacagtga tttaccgctt 249301 ttttataaaa tatcagaaaa taaagatatt gacttattgt ttatttgtct tacaattaaa 249361 caaaaggata tatgggaagg agcggatgtg aaagaaaaat taataaaagc gcttacagat 249421 agaggccgta tacacaaata acaggaggtt atgttgatga gccgtatcag aaaagcaccc 249481 gctggaattt taggttttcc ggttgctcct tttaacacac aaggaaaact ggaggaagaa 249541 gctctttttc aaaacattga gtttttgctg aatgagggct tggaagcgat atttatcgct 249601 tgcgggtctg gtgaattcca atctctcagc cagaaggaat atgagcaaat ggtggaagtc 249661 gcagtctcgg cagccggagg aaaggtgccg gtctacacgg gggtgggcgg caacctcagc 249721 acagcgcttg attgggcgca gctgtcggag aaaaaaggcg ccgacggcta cttgattctg 249781 cctccgtatt tggtgcatgg cgaacaggag gggctgtacc agtatgcgaa aacgattatt 249841 gaaagcactg acttgaacgc gattctttat cagcgcgata acgcagttct ctctgttgaa 249901 cagatcaaac gtctgaccga atgtgaacag cttgtcggtg tcaaagacgg ggtaggaaat 249961 atggatttga atatcaatct cgtctatacg atcggcgacc gcttgggatg gctcaacgga 250021 atgccgatgg ctgaagtgac gatgccggct tatctgccga tcgggttcca ctcttactct 250081 tcagcgattt caaattatat cccgcatatt tcgcgaatgt tctatgatgc attgaaaaac 250141 ggaaatgacg agcttgtgaa ggaactctat cggcatgtga ttctgccgat caacgacatt 250201 cgcaaacaac gaaaaggcta cgccgtatcc ttgattaaag ccggtatgga aatcatgggt 250261 ttgaatgtaa ggaatacagc cagaccgcct gtcggcccgg ttgaaaaaga tcattatcag 250321 caattggaag caattttgaa gcaggcggct gaccgttttc cgaaaaaagc cgcgacggtt 250381 tgaccagaaa aaacacgaaa ggggcaatgg gcatgtctgt gatcacggaa caaaacacgt 250441 acctcaactt tattaacgga gagtgggtta agtctcaatc aggcgatatg gtcaaagtcg 250501 aaaaccctgc cgatgtgaat gatattgtcg gatatgtaca gaattcaacg gctgaagatg 250561 tggaacgtgc cgtcaccgcc gccaatgaag ccaaaacggc ttggagaaag ctgacgggtg 250621 ccgagcgcgg ccaatactta tacaaaacag cggatatcat ggagcagcgc ttggaggaaa 250681 tcgccgcctg tgcaacgcgt gaaatgggta aaacattgcc ggaagcgaag ggagaaacag 250741 cccgggggat tgccattctg cgctattacg ccggagaggg catgcgaaaa acgggtgacg 250801 tcattccgtc tactgacaaa gacgcgctca tgtttaccac ccgtgttccg ctcggtgtgg 250861 tcggtgtgat ttctccgtgg aacttcccag tggcgattcc gatttggaaa atggcgccgg 250921 cattggtata cggcaatacc gttgtcatca aaccggcgac agaaacagct gtgacatgcg 250981 cgaagatcat tgcctgcttt gaggaagcgg ggctcccggc aggggtcatc aatttggtga 251041 caggcccggg ttctgttgtc gggcaggggc ttgctgagca tgacggtgta aacgccgtta 251101 cgtttaccgg ttcaaatcaa gtcggaaaaa tcatcgggca agccgcttta gcgaggggag 251161 ccaaatatca gcttgagatg ggcggcaaaa accctgtcat cgtagctgat gacgctgacc 251221 ttgaagctgc ggcagaagct gtcataacgg gggccttccg ttcaaccggc cagaaatgca 251281 ccgcgacaag ccgtgtcatc gtacaaagcg gaatttacga gcgctttaaa gaaaaactgc 251341 tccagcgcac aaaagatatt acaatcggag acagcttaaa agaggatgtc tggatgggac 251401 cgatagccag caagaatcag cttgataact gcctgtcata cattgagaaa ggcaaacagg 251461 agggcgcttc ccttttaata ggaggagaaa agctggagaa cggaaagtat caaaacggct 251521 attatgttca gcctgccatc tttgacaatg tgacatctga gatgacaatt gcccaggagg 251581 aaattttcgg tccggtgatc gccttgatca aggtggactc gatagaggag gcgctgaaca 251641 tcgccaatga tgtgaagttc ggtttaagtg catccatctt cacggaaaac atcggccgaa 251701 tgctttcttt cattgatgaa atcgatgccg ggctggttcg gatcaatgca gaaagcgcag 251761 gtgttgagct gcaggcgcct tttggcggca tgaagcagtc gagctcccac tcccgagaac 251821 agggtgaggc agcgaaggac tttttcacag cgatcaaaac tgtttttgtg aagccgtaat 251881 ggtgctggaa agaggcgtgc gtctctttcc cggtttatca caaccagcat atgattctct 251941 actttgaaaa ggagaagata ctatgaaaaa agactttgcg agtgttactc cggcgggcaa 252001 aaaaacgtcc gtgcgctggt tcatcgtgtt tatgctgttt cttgtgacct ctattaacta 252061 cgcggatcga gcgacgcttt ccatcaccgg agattccgtc cagcacgatt tgggattgga 252121 ctcggtcgcc atgggatatg tcttttctgc ctttggctgg gcctatgtca tcggacagct 252181 tccgggcggc tggctgctgg accgttttgg ttcaaagact atcattgcgt taagcatctt 252241 tttctggtcg ttttttacgt tgctgcaagg ggcgattggc tttttctccg ccggcacagc 252301 gattatcctg ctgtttgcac tgcgttttct ggttggttta tcagaagcgc cttcatttcc 252361 cggaaacggc agagttgttg cctcatggtt tccaagctcc gagcgcggga cagcttcagc 252421 cttttttaat tcagcacaat acttcgcaat cgtcattttt tctcctttaa tgggctggct 252481 tacccactct ttcggctggc attccgtttt cgttgtcatg ggtattgcag gcattcttct 252541 ggctgtcatc tggctaaaaa cggtgtatga accgaaaaaa catccgaagg ttaatgaagc 252601 tgagcttgcg tacatcgaac agggcggcgg gctgatttcc atggatgaca gtaaaagcaa 252661 acaagaaaca gaatcgaaat ggccgtatat caaacagctg ttaacgaacc gcatgctgat 252721 tggcgtgtac atcgcgcaat actgtattac gactctcacc tatttctttc tcacatggtt 252781 tccggtatat ttggttcagg cccgcggcat gtctattctt gaagctgggt ttgtcgcttc 252841 cctgccggcg ctgtgcggat ttgccggcgg cgtgcttggg ggcattgtgt cagacatctt 252901 actcaaaaaa ggccgttcac tgacctttgc aagaaaagtg ccaatcattg ccggcatgct 252961 gctgtcttgc agtatgattg tctgtaacta cacagattca gcatggctcg tcgttgtcat 253021 tatgtcgctc gcgtttttcg gaaaaggctt cggcgcattg ggttgggctg tcgtgtcgga 253081 cacgtctccg aaagaatgtg caggattaag cggcggtttg ttcaacactt tcgggaatat 253141 tgcctcaatt acaacaccga ttattatcgg atacattgtc aatgccactg gatctttcaa 253201 tggcgcgctt gtgtttgtcg gcgctaacgc gattgcggcg atcctcagct atttgctgct 253261 ggtcgggccg atcaaacggg tcgtgttaaa gaaacaagaa caagaccccg atcaatcgtt 253321 gcctgtctaa tatttatgaa agcgctttat aaagggagga aaatgcatga gttcaccgat 253381 acaagagcag gttcaaaaag aaaaaagatc gaatattccc tcaatttctg aaatgaaggt 253441 gattcctgtt gcgggacatg acagcatgct gctgaatcta agcggagcac acagcccgtt 253501 ttttacccgg aatatcgtaa tcttaacaga cagcagcgga aatcagggag tcggcgaggt 253561 gcctggcgga gagcatattc gccgcacact ggagctgtca gagccgcttg ttgtcggaaa 253621 atctatcggt gcgtaccagg cgatattgca aacggtcaga aagcagtttg gcgatcagga 253681 caggggaggg cgaggaaacc agacgtttga tttgcgcacc actgtgcacg ccgtcaccgc 253741 actggaagcg gctttgttgg atttgcttgg aaagtttctt caggaaccgg tcgcggcttt 253801 gctgggcgaa gggaagcagc gtgatgaagt aaaaatgctc ggttacctct tttacatcgg 253861 cgaccgaaat cggacgacct tgccgtatca aagcgatgag cagtcagatt gtgcgtggtt 253921 ccgtctgcgc catgaggaag cgctgacgcc ggaggccatt gtgcgtcttg ccgaatccgc 253981 acaggagcgc tatggctttc aggatttcaa attgaaaggc ggggtgctgc ggggagaaga 254041 ggaaatcgaa gctgttaccg cattatcgaa acgttttcca gaggcaagga tcactcttga 254101 tccgaacggg gcatggtcat tagaggaagc tattgcatta tgcaaaggaa agcaagatgt 254161 gctcgcgtat gcggaagatc catgcgggga tgagaatggc tactccgctc gtgaagtaat 254221 ggctgaattc cgccgcgcga cagggcttcc gactgcgaca aatatgattg cgactgactg 254281 gcgggaaatg ggtcacgcga ttcagctcca cgcggtcgat ataccgctgg ctgatccgca 254341 tttttggacg atgcaagggt cggtgcgggt tgcgcaaatg tgccatgatt ggggtttgac 254401 atggggctcg cactccaaca accactttga tatttccctt gcgatgttta cccatgtggc 254461 agcagcggct ccggggcgga tcacggcgat tgatacccat tggatctggc aggacgggca 254521 gcgattaacg aaacagcctt ttgagatttc ttctggctgt gtcaaggtgc cggataagcc 254581 tggactaggc gtcgatattg atatggaaca agtggaaaaa gcgcatgaga tctatcggaa 254641 aatgaattta ggcgcacgga atgatgcgat cccaatgcag ttcctgatca gcaactggga 254701 atttgaccgg aagcgcccgt gtcttgtgcg ataagtttga ttgtaaatat tgtcatatcc 254761 gctattttgt cttacaattg aacaactgaa gggagagttg ttcgtgtacg aaggtttaga 254821 ggatttgaaa gtcgatacag tcaatcggaa aacattagcc aagcaggtca tcgaacggat 254881 tgtccattta ttatcgagcg gacagttgag ggccggagac aaattgccga cagaaatgga 254941 actgatggac attttgcatg tcagcaggcc ggtgctacgg gaagcactca gttcacttga 255001 aacgctgggc gtcattacga gaaaaacacg agggggcaca tatttcaacg ataaaatcgg 255061 catgcagcca ttttccgtca tgcttgcttt ggccactgat aatcttccgg ctatcattga 255121 agcgcggatg gcgctagaac tcgggctcgt gacaattgcc gcggaaaaaa tcaatgagga 255181 agagcttcag cgtttgcaga agacgatcga cgatattgcc aacagcactg acaatcatta 255241 tggtgaagcg gataaagagt tccatcgaat tattgcgtta agcgccaata accccgtcgt 255301 tgaagggatg attcagtccc tgctgatcac ccatgcgaaa attgacagcc aaattccgta 255361 cagggagaga gatgtaacgg tcgaatatca caaaaaaatc tacgacgccc ttgccaaaag 255421 agatccgtac aaagcacatt accacatgta tgagcatctg aaatttgtcc gtgacaaaat 255481 tctaaaagga atggatgaaa aataatggtg agcaaccgca gttgaaacgt aagagctgcg 255541 gtttttttaa accaatttag aaaacgctta ctaaaatatg aggagtgatt ttcatatggc 255601 gatgaacctc aggaagaacc aagcccccct ttacatcaaa gtgcatgaaa tagataacac 255661 cgcgattatt gtaaatgatg gagggctgcc aaagggcact gttttctcat gcgggctcgt 255721 acttgaagag gatgttcctc aaggccataa ggtggccctc accgatctca atcaagggga 255781 cgagatcgtg cgttacggag aggtgatcgg atttgctgat gagacgatca aacgcgggag 255841 ctggatacgg gaagccctcg tgagaatgcc cgctcctccg gcgttagacg atcttcctct 255901 cgcaaacagg gtgccgcagc cgcggccccc acttgaagga tatacatttg aaggataccg 255961 aaatgcggat ggcagtgcgg ggacaaaaaa tatcctcggc atcacgacaa gtgttcaatg 256021 tgttgttggc gttttggatt atgcagtcaa acgaataaaa gaagagctgc tgccgaaata 256081 cccaaatgtc gatgacgttg tgccgctgca tcatcaatac ggatgcggcg tggcgatcaa 256141 tgcgcccgac gctgtcattc cgatccgcac gattcaaaat cttgcgaagc atccgaactt 256201 cggcggtgaa gtaatggtaa tcggattggg atgtgaaaag ctcctcccgg aaagaattgc 256261 ctccgaaaat gatgatgaca ttctatcgct ccaggatcac cgaggttttg cggcgatgat 256321 ccaatccatt ttggaaatgg cggaggaacg gttaatcagg ctgaacagca gaacccgggt 256381 gtcatgccct gtttcggatc tggttatcgg cctgcaatgc ggcggcagtg atgcgttttc 256441 cggcgtgacg gcgaaccctg ccgtggggta tgcggctgat ttattggttc gcgcaggtgc 256501 aacggttttg ttttctgaag tgacagaggt gcgggatgcc attcatttat taacgccgcg 256561 ggctgtcagt gaagaggtcg gacaatcgct gatcaaagag atgaagtggt atgacagcta 256621 tcttcggcgg ggagacgcag accgtagcgc aaacccgtca ccaggcaata aaaaaggcgg 256681 attatccaat gtggtggaaa aagcgttagg ttcggtagcg aaatcaggca caagccccat 256741 ctccggcgtg ctcggccctg gtgaaagagc aaagcaaaaa ggcctgctgt tcgcggcgac 256801 accggcaagc gattttgtgt gcggcaccct gcagctggct gcgggcatga atttgcaggt 256861 gtttacgaca gggagaggaa caccatatgg cctggctgct gcgccggttc tgaaagtatc 256921 gacgcggcat tccttatcag agcattgggc tgatttaatc gatatcaatg ccggccgaat 256981 cgcgacagga gaggccagta tcgaagacgt aggctgggaa atcttcagga cgattttgga 257041 tgtggcaagc ggccgcaaac aaacgtgggc agaccgttgg ggtcttcata atgatttgtg 257101 cttgtttaat cctgctccag tgacttgatt catgttttta tagcggaaag atggaatatg 257161 ctgtaaaatg aaaatcagcg tataggaaac ggaggggtta cagcatggca ttcattagat 257221 tccgagtgac acgaattcaa tagtgaacaa ctctcgcctg aatgcgagag aatcgggatg 257281 aatccgccta tgtatgagcc cttatatggt tatcaaaaaa gagggtggcg tgcctgccct 257341 tttttgtgcc ttcaagcatc ccttctctct actgcaggcc ggagcatgag aaaggggaaa 257401 tgggatgaca aaccttaacg aaaaacagct tatcactgag attgtcgggc ttgcacgcag 257461 ccaaggtttg acggttcatt ctgagaacgc gcaattgaat gaaaccggaa tggactttca 257521 agttgtattt gccaaggacg acacaggtat gccatgggtg ctgcgaaaac cgcggcgaag 257581 tgatgttgtg gaaagagcat ctgcagaagg cataacgctt gcctttctcc gcgcgaatct 257641 gactgctgat gtgccggatt ggagaattca tacaccggaa ttgatcgctt accccatgtt 257701 aaaaggaacg ccggctgctg gaattgactt ggaacaaaag caatatgtat ggaatatgga 257761 tcatcagccg ccgtcagacg actttgtccg cacacttgcc gacatactgg ctgaattaca 257821 tggcacggat caaatatctg ctgggcaatc cggaatagaa gtgataaggc cagaagattt 257881 caggcaaatg acagcagact ctatggttga tgtgaagaat aagcttggcg tatctacgac 257941 gctttgggaa agatggcaaa agtgggtaga tgatgatgca tactggccgg gtttctcttc 258001 tttgatacac ggcgatctcc acccgccgca tatccttatc gatcaaaatg gacgtgtcac 258061 aggacttctg gattggacag aagcgaaggt tgctgaccca gccaaggatt ttgttcttta 258121 tcaaaccatt ttcggagaaa aagaaactgc ccgtttgctt gaatactatg atcaagcagg 258181 cggccgaata tgggcaaaaa tgcaggaaca catctcagag atgcaggcgg cgtatccggt 258241 ggaaatcgcc aagctagctc tgcaaacaca gcaggaggaa cacatcaata tggcgctgga 258301 agcacttggt gtaacatcgg attaagaatt gacttcgttt catgaaccga gtattataaa 258361 ctctacaaat aatagaacgg attaacaatc gtgaggaaga gcaagtacgc atcagaatgg 258421 aggttcagag agtcggtggc aggtgtgaac cgatcctccc ctgatgccga atgggcttct 258481 gaattgcttt gctgaacgga tagtaggcga tgccgggttt ctctccccgt taccaagaga 258541 ggagtatcga aacataggtt ttctgtactt agagtgaacg gctgtatagc tgttaataaa 258601 ggtggtaccg cgagaccctc gtcctttgca taggacgggg gttttttgtg tttcttaaag 258661 gaggtgacgg ccaatgtacg atggctggtg gtggcatagc agatgagtta gaaaggagga 258721 tatcaaatgg tcattgcaac tgatgatctt gaggtcgcat gtcctaaatg tgaaagagcg 258781 ggagaaatcg aaggaacacc ttgcccggcc tgcagcggaa aaggtgttat tctgactgct 258841 caaggatata cgcttctcga ttttatccaa aagcatttga ataagtaaag gagaaaagct 258901 gagctgagat gagagcagaa gagcagagta agattcgtga ggccgcagca ggtacgattt 258961 ttttgctgat cggaacagtt tgttttgcgt ctaaatcgat ttggataaaa tgggcatacc 259021 aaatgggtgc tgagccagat gccgtgctgc tatacaggca gctgctggct gttccgctgt 259081 tttggctgat ttttttaata taccgtcctc caatgccaga cggtaagaaa aaaggagacc 259141 tatggaaggc ttgtggcgcg ggagtgtttt gtttttttct gtctcccttg cttgatttta 259201 tcgggctgaa ccatgtatcc gcaatggttg aacgtatatt gctgatgagc tatccgttgt 259261 ttgtgtttgg attcaccgcg tgtcgtgacc ggaaaatgtc ctcaattcag gaccttttcg 259321 cagttctggc ggtcatgttt gggcttttct tggcgctggg cggctggaat gctgagcttt 259381 tccaggcgaa tatgattgga gctgtattca ttttgttatc ttcggccgtc tatgctggtt 259441 atcttgtcct ttccgggcat ctcgtccatc aaatcggagg gatccgtctc aatgcatacg 259501 ggatgacagc tgctggagct gccatgatgc tttacacagg gataaaatcg gcggctggca 259561 tgaatacgcc aatggcagca tatccgcttt ctatgtatgg tttgttcgca gtaattgcag 259621 tcgttaccac agtgattcca tttgtgctaa tgcttgaggg cataaaacga atcggggcac 259681 agcgagccgc cgccatttca atggcagggc ctatcctgac gattttctat ggagctttat 259741 ttctcggtga acggctcggg ctcattcaag tcattggatg cggtggcgta ttttttgtca 259801 ttacgggcat ggaatacagg aagctgaaaa caggaaaaaa agaataattt ttataaaaca 259861 cacacgtttt tcaattacaa taagtgtaat tacgtgtgtg ttttttgatt ttgtaaaggt 259921 taggtgagga gatgcagcgc atattgcttg tagaagacga ccactcaatc agtgaaatgg 259981 tggatcatta tttaacaaaa gaaggctttg gaattgtgca tgctttcgac ggagaagagg 260041 gcatccggct gtttcagcag ggttcatacg atttggtcct ccttgatatc atgctcccga 260101 agctgaacgg catggatttt ctgaaaatca tccgggaaaa aagcaatata ccggtcttaa 260161 tgatttcggc aaaagatgga gatgtggaca aggcattggg actgggcttt ggggcggatg 260221 attatatcgc caaaccgttt tcgatgattg agctgacagc ccgagtaaaa gccgcgatac 260281 ggcgggcgac gcaatattcg gcagaggagc cggctgtgaa taaggtgatc cggattcacc 260341 agcttgcgat agatatagac aatgtttccg ttttgaaaaa cggagagccg ctccagctga 260401 cgtcaacaga atggcagctg ctgtgcttat ttgcatcaaa tcctaaaaaa gtgtttacga 260461 aagaacaaat ctaccgttcc gtttggaatg aagagtactt tgatgatcag aacatcatta 260521 acgtacatat gcggcggctc agagaaaaga ttgaggatga cccctcctcc cctcaatata 260581 ttaaaacgtt atggggcatc ggttataaat taggagagtt ttagaatgac agtgctatgg 260641 gtggccgctg tcatcgctct ggcgtgtctg aatgtgattc aattcataat gaaaaagaag 260701 cgggacggga atctggctta cacggctgac cagcttagct acatgctcag ccgggattcg 260761 gcaggacaaa ttttgcttcc tacagacgat catgcgctca aagacttgct tgttaacatc 260821 aatcttatcg ttgagaatcg tcagcagatc agcgcccaat ttgccaaaac agagcaatcc 260881 atgaagcgga tgctgaccaa tatgtcgcac gacctgaaaa cgccgttaac ggtcattctc 260941 ggttatattg aagccattca aagtgacccg aacatgccgg acgaagagcg ggaaagattg 261001 ctggggaagc tccgccagaa aacaaatgaa cttattcaga tgatcaattc cttttttgat 261061 ttagcgaaat tagaatctga agataaagag atcccgatca ccaaagtaca tatgaacgac 261121 atatgcaaac gaaatatcct gcactattat gacgctgttc agtcaaaagg ctttcaagca 261181 gccatcgata tccccgatac gccggtgtat gcgcaggcga atgaagaggc tctggacaga 261241 atcctgcaaa acctattgtc caatgcgatt caatatggcg cggccggcaa gttaatcggg 261301 ctgacgctgt cttatgatga gaggaacatc gccatcaccg tatgggatcg cggaaaaggg 261361 attagtgaaa ccgatcagca gcgggtgttt gagaggctgt acacactgga agaatccaga 261421 aataaagcat ttcaaggaag cggcttgggt ttaaccatca caaaacggct tacagaaaaa 261481 atgggaggca tcatatccgt ccaaagcaag ccgtacgaac ggactgcatt tacgatcaca 261541 ttgaaacgca tgacatatta atcgtaagaa tttcttaagg tttgagaaat aaaaatgaca 261601 gggctcgccg ctacaataga aaacaggaaa agagagggaa ggagaaacaa agttgactta 261661 tatcgtacaa acaaacgggc tgaccaaaac atatcagggc aaagaggtcg tatccaatgt 261721 cagcatgcat attaaaaaag gtgaaatcta tggctttctc ggcccgaacg gcgcggggaa 261781 aacaaccatt atgaaaatgc tgacgagcct tgtcaaaccg acaagcggtg aaatcatcat 261841 ccttgggaac aagttcaccc acacgtcata tgaggtgctg gggaacatcg gcagcatgat 261901 tgaatatccg attttttatg aaaacctgac agctgaagaa aatttagatc tgcattgtga 261961 atatatggga taccacaata aaaaagccat acaagaagtg ctggatatgg tgaatttaaa 262021 acaaatcgac aaaaaacccg tcaaaacctt ttccctcggg atgaagcagc gccttggaat 262081 tgcgcgtgcc atcctcacga agccggacct gcttattctg gatgagccgg tgaatggtct 262141 tgaccctctc ggcattaaaa agatcaggca attgtttcaa gtgctgagca aagagtacgg 262201 gatgacgctg ctgatctcaa gccacctgct gggtgaaatc gaacaaatcg cggacacaat 262261 cggcgtcatt cgggacggca ggctgcttga agaggtatca atggaggatg tcaggggcca 262321 gaacactgaa tacatcgagc ttgtcacgcc gaatcagaca agggcctgct ttgtgctgga 262381 gaaagagctg caattaacca actttaaaat attaaatgag aaaacgattc gaatttacga 262441 ggctgaagcc tctcaggctg ccatatccaa agcattgatt ttaaatgatg tagacattga 262501 atcaatgaac aaaaagtata cgtcgctgga ggattatttt atcaaattga tcaacggcaa 262561 tagcatcagt gcgtaaagga ggagagacac gttgatgaat ttgatcagaa tcgaattaag 262621 aaaaatgaaa atgggctggt atatcagagg tgccctcatt gccaacgtga tcattatggg 262681 ttttatgtgg ctgatcagtt attccgaaaa agccgatggc ggggtttcgt tccaaagtac 262741 ggatgaagca ttcctcatca tcggcacctt cgtcagagcg gtatttatcg tatttggcgc 262801 tgtgctgatc gtaaaattgg tgatttcgga atataaaaac aaaaccattc ttgtgatgtt 262861 cacgtacccg atcagccgta aaaagctgct caccgctaag ctcatgatcg cgggcggact 262921 gacgtttatc acgattttac tttcaaatat actcatagcc gccggtttct tttggctgaa 262981 ctcgatctgc catttcatac cgggagagct tacttccgag atcatttctc aacaggcggt 263041 caaaatggcg gttttcgctt ttggcgccgc tggaaccagt ttagttccca tcttttttgg 263101 gatgcgtaga cactcggttc cggcgaccat catttcatct gtagtaattg tgatgctcat 263161 cagctcaaca agtccgggct tctcgatttc atctgttgtg tatatcccgt tatcgttagc 263221 ggcattcggt ttgttctttt cctacatggc gatcaggaat gcggacaagc aggatgcgta 263281 aacaaaggcg cccaatatgt ataaaaggcc gatgctgtca gcaccggcct ttccattatg 263341 agtctgttct tgtttcaaga taatgcttct tgccaatctc tttgctcatc atatagaaat 263401 ggaagcaata ttcaccgatt gccatgacga tcgcgccgaa taaagccgcc aatgcaactt 263461 caccgccagt catccccata gaaagcggca tgcccatcag ccagatcacg agaaaggcca 263521 aaccaaaatc agccaaagtt gcaatcatat tattccattt cggcaataca taaagatcgc 263581 ccagcaaata agaaataacc cctaacacaa tcgtcattag cagcgtatca ccaaacgtga 263641 aaccaaagcc cagaccaagc accagataca acacaataat cgtcataata cctttaatag 263701 cgagcgcttt cacatgtgtc attacaattc ctccttttgt catttgattt gttatgtata 263761 attcctcaaa tgtaaaaagt taaaccttat ttcttttcgg aggcgggtgc aaatctgctg 263821 gggagaggtc aatgatgtga atccaggaat tgaggctgcg gcgcttcgac agcggaaacg 263881 tgaagcttgt actgcaccgg acgctgcttt gatgcccaac agcccattat gtttgctgtt 263941 tttagatgaa taaatttaaa aacttctcct gtccctccgt catcacttct gaagtaatga 264001 aatatgatga aaagagatca aggggaggtg acgtgatggc ggtcgtgaga gcaacgagtg 264061 cggatgtcga tttgatggca aggctgctca gagcggaagc ggaaggcgaa ggcaagcagg 264121 ggatgctgct tgtcggcaac gttggaatta atcggctgcg ggcgaattgc tcagatttta 264181 aaggcctccg caccatcagg cagatgattt atcagccaca cgcgtttgag gctgtgactc 264241 atggatattt ttatcaaagg gcgcgagata gcgagcgtgc ccttgcacgc cggtcgatta 264301 atggtgaaag gcgctggcct gcaaaattta gtttatggta cttcaggccg cagggggact 264361 gtccagccca gtggtataac cagccgtttg tggccagatt taagtcacac tgcttttatc 264421 agccgacggc ggagacgtgt gaaaatgtat ataacacatt ttagagacag gacaccgttc 264481 aaattgaacg gtgtttttct ttgaaaagat gcaatgcaaa atattcctgt gagataatca 264541 aagaaaaaag agctgacgga gatgacagaa tggcaacaat tgacctgcaa aagaaaagtg 264601 taaagatcgt actggagaaa aagcagttaa cgaaggtgac ggctcgtgtt ggactggttc 264661 ttgatattac gggatcgatg agaccgctct acaaaaacgg gacggttcaa aatgtggtgg 264721 agcggatttt ggcagtggct gatcagtttg atgataacgg tttgctggat gtatgggtgt 264781 atgataatga attttcccga ttaaagccag tttcagaaaa ggatttttcg ggctatgtcg 264841 atcgtgaaat tttaaataat gaccgcttgc ataaattcgg cagaaatgat gagccgccag 264901 tcatgaagga cgtgctgcgc aaatatgtta cggaggaacc gagctcgtat cctgctttca 264961 ttgtttttat caatgacggg ggctgtaaaa agtcaatcaa accgataatt gaagcttctt 265021 ctgataaacc ggtgttctgg cagtttgtcg gcatcggaaa cggaaacttt gattttctca 265081 ataaactgga tacgttagaa gggcgtgtca ttgataacac gaacttcctg catatcgaag 265141 agattgaccg catttctgat gatgagcttt atgatgctct gcttgctgaa tttccatttt 265201 ggctgaaaga agcgaaggaa aaagggattg taagagaaca agagcctcct gctgaaaagc 265261 cgaaaaagaa gggctttttc agcagattgt tttcgaaata actgataaag agcactgagt 265321 cattctgcga aatggctcgg tgtttttgtt tttttaagat catgtgaaga aaaataggcc 265381 gaatgggcgg cttgcaaacg acaggatatg cagaaaacgc gtcattcagc cagctttcgg 265441 catgtttcag cagcaggctt gtgagggaag acctgttttt aatgttcagc gcttacaatc 265501 agttcacact tcttcacagt cgtttaacaa tgatttccta taatggagac gatcaatgag 265561 gagagagggg atcttgaatg gcatacgaca gtcgttttga tgaatgggta cagaaactga 265621 aagaggaaag ctttcaaaac aatacgtttg accgccgcaa atttattcaa ggagcgggga 265681 agattgcagg actttctctt ggattaacga ttgcccagtc ggttggggcc tttgaagtaa 265741 atgctgcgcc taacttctca agctatccgt ttacattagg ggtagcgtca ggtgatccgc 265801 tttctgacag tgtcgtgctt tggacacgtc tggcaccaga tccgctgaat ggcgggggaa 265861 tgccgaagca agcagtgcct gtcaaatggg aggtcgcaaa ggatgagcat ttccgcaaaa 265921 tcgtaagaaa aggcactgaa atggctaaac caagtcttgc ccattccgtt catgtggaag 265981 cggacgggct tgagccaaac aaagtgtact attaccgttt caaaaccggc catgaactaa 266041 gccctgtcgg aaaaacaaaa acactgcctg cccctggcgc caatgtgccg caaatgacct 266101 ttgcatttgc ttcctgccag caatatgagc acggatatta tacggcctac aagcatatgg 266161 caaaggaaaa gcttgatctt gtcttccatc tcggtgatta catatatgaa tacggcccaa 266221 atgaatatgt atcaaaaaca ggcaatgtcc gcacgcacaa cagcgcggaa atcattacgc 266281 tgcaagacta tcggaaccgt cacgctcaat accgttctga cgccaatctt aaagctgcac 266341 atgcggcatt cccttgggtt gtaacttggg atgaccatga agttgaaaac aactatgcca 266401 ataaaatacc tgaaaaagga cagtcggttg aagcattcgt gctccgccgc gcggcagcat 266461 accaggcata ctatgaacat atgccgctcc gcatttcctc tttgccgaat ggcccagata 266521 tgcagctgta ccggcacttt acgtacggaa acctggcgtc cttcaatgtg cttgataccc 266581 gccagtacag ggacgaccaa gccaataacg acggcaataa gccgccttct gatgaatcgc 266641 gcaatccgaa tcggactctg cttggaaaag aacaggagca gtggctcttc aacaatttgg 266701 gcagctcgac agcccactgg aatgtgctgg cgcagcagat tttctttgcc aagtggaatt 266761 tcgggacaag cgcaagcccg atctacagca tggattcgtg ggacggctac ccggctcagc 266821 gcgaacgggt tatcaatttc attaaaagca aaaatctgaa taatgttgtc gtactgacag 266881 gtgatgtaca cgcaagctgg gcatcgaatt tgcatgtcga tttcgagaag acaagttcaa 266941 aaatattcgg agccgaattt gttggaacct cgatcacttc cggagggaac ggagcggata 267001 agcgagcgga tacggaccaa attttaaaag aaaatccgca catccagttc tttaacgact 267061 atcgcggata tgtccgctgt acagtgacgc ctcaccagtg gaaagccgat tatcgggtga 267121 tgccatttgt gaccgagccg ggcgcagcca tttccacgcg ggcttcattc gtttaccaga 267181 aagaccaaac cgggttgaga aaggtatcat ccacaacaat ccaaggcggg gtgaagcaat 267241 ccgatgaggt cgaagaggat cgtttctttt cgcacaacaa agcccacgaa aaacaaatga 267301 ttaagaagcg tgcaaaaatc acgaattaag gagtggaaat tatgttttca aacattggaa 267361 taccgggctt gattctcatc ttcgtcatcg ccctcattat ttttggccct tccaagctgc 267421 cggaaatcgg gcgtgccgcc ggacggacac tgctggaatt taaaagcgcc acaaaatcac 267481 ttgtgtctgg tgatgaaaaa gaagagaaat cagctgagct gacagcggta aagcaggaca 267541 aaaacgcggg ctgaatgctg atgaggcaga caccgggtct gcctcttttt ttatgaaagg 267601 gagggctttt ttgaatggat aaaaaagaaa cccatctgat cgggcattta gaagagcttc 267661 gccgccggat tatcgtcacc cttgcggcat tttttctatt tctcatcacg gcttttttgt 267721 tcgtacagga catttatgac tggctgatca gggatttgga tggaaagctg gctgtgctag 267781 gaccgagtga aatcctctgg gtgtatatga tgctttccgg catttgtgcc attgcggctt 267841 ctatccctgt tgccgcgtac cagctgtggc gtttcgttgc accggcgctg actaaaacgg 267901 agcgcaaggt gacgctcatg tacataccag gtttatttgc gttgtttttg gcgggcatct 267961 ccttcggata ctttgtcttg tttccgatcg tgctcagctt tttgactcat ttatcctccg 268021 gccactttga aacgatgttt acggctgacc gctactttag gtttatggtg aatttgagcc 268081 tgccgttcgg cttcttgttt gagatgccct tggtggtgat gtttttaaca aggctgggca 268141 tcttaaatcc ttacagactg gccaaagcga gaaagctttc ctattttctg ctgattgtcg 268201 tgtccatatt gattacaccg cctgatttta tttctgattt tctcgtgatg atcccgcttc 268261 ttgtcctgtt tgaagtgagt gtcaccctat cggcgtttgt ctacaaaaag aggatgaggg 268321 aagaaacagc ggcggccgct tagtgcagcg taccacccgg tgacttcaca tcctcatcat 268381 attgtgcggc cgtaacagcg gcgattctca atgcccggac aatcgtgtcc aggctgaggc 268441 tcggcgctgt tttgtcgatt gtttgctgcg gaatgtaagg aatatgaata aaaccgccgc 268501 gaatgtgtgg ggatgtccgg ctaatgtgat ccattaaccc gtagaacaaa tagttgcata 268561 caaaggtccc cgctgtgtag gaaaccgcag ctggaatgcc gtgttccttc atcttagcag 268621 tcattcgttt cacgggaagc cttgtccagt aagcggcggg cccatctgga gaaatctctt 268681 catcaatcgg ctgatgtcct tcgttatcgg ggattcgcgc atctgcaagg ttgattgcca 268741 ctcgttccgg tgtaatctgc atccgtcctc ctgcttggcc gacacaaatt acgatatctg 268801 gctgatgttt ttgaatggct tggcgcagag tgtccagagc ggatctaaag acggttggaa 268861 tttgttccgc tgtaataatg gcttcttctg tctcgaagcc attaagccgt ttcgccgctt 268921 cccatgatgg attgacggtt tctttgtcaa aagggtcaaa gcctgtgatc agcacttttt 268981 ttctcattct cccatctcct ttttctttta ttctattgtt tatttatggg tttttcatca 269041 aaataatgta aaggagtgaa tcataatgga gcatttgccg gagcagtatc gccagttatt 269101 cccaaccttg cagacgcata cgatgcttgc cagctgttct cagagcgcat tggcagagcc 269161 tgtatcaagg gcgatccagg attattatga tagcctgctg tataaaggga cgaactggaa 269221 agaagcgatt gaaaaaacag agtttgcgag aaacgagttt gcaaagctga tcggggctga 269281 accggatgaa gtggcgattg tgccgtcagt ttctgatgca ctggtttctg tagcatcgtc 269341 cttaactgca tttggaaaga agcacgttgt atatacagat atggattttc cggcggtgcc 269401 tcatgtttgg caggcacact ccgattatac cgtatccgtc attccatcaa tagacggcgt 269461 gctgccgctt gaacaatatg aaacgcatat ttcggatgaa acagtactga cgtgtgttcc 269521 tcacgttcat tatcgtgacg gctatgttca ggatataaaa gcgattgccg agatttctca 269581 gagaaagggc tctttattgt ttgtagatgc ttatcaatca gccgggcata ttcccattga 269641 tgtgaaggaa tggggcgtag atatgctggc agcaggcacc cggaagtatt tgctcggcat 269701 accgggtgtg gcgtttcttt atgtgagaaa ggagctggct gacgcactga agccgaaagc 269761 atcagcttgg ttcggaagag agagcggatt tgatggggct tatgcaaaag tcgcgcgccg 269821 ttttcaaacg ggcaccccag cttttatcag cgtatacgca gctgcagcgg ctttatcgct 269881 gctgaatcat attggggttt ctcatatcag ggatcatgtg aaaacgatct gtgccgatgc 269941 agttcaatat gccgctgaaa aaggcctgca gctggcggcg gcacaaggtg ggattcagcc 270001 gggcatggtt gcgatccggg atgagcgggc atcggaaacg gcggggttgc tgaagaagaa 270061 aaaagtgatt tgcgcgccgc gggaaaatgt tatccgtctc gctccccatt tttataatac 270121 gaaggaggaa atgcggcacg cgattgatga aatcgcggcg aaaacgatcc acaagtaaac 270181 atgaaaaagc ccctgaacac tagtcagggg cttttcatat taatgatcta ctttaacgcg 270241 tttcataaag aaagcgccaa ttaaaccgat aatggcaaca atcattgcaa acacaaatgc 270301 gtgctgtacg cctgctgtca aagcttgcgg gatgactgcc ggatcggcag ggtttttaac 270361 tgtactcata taatcatgct ggcctgcagc cataatgctg accgcaaccg ctgttccgat 270421 agcgccggcc atttgctgca gcgtgttcat aatggcggtg ccgtctggat aaaattcacg 270481 cggcagttgg tttaaaccgt ttgtctgtgc aggcatcatg atcatagaaa tcccgatcat 270541 caagcaggtg tgcaggatga taatcagcac agctgttgaa gtggtcgtga catttgagaa 270601 gaaccatagt acaacggtga caatcacaaa tcccggaatg acaagccatt tcggcccgta 270661 tttatcgaac aagcggcctg taacagggga cataaatcca tttaaaatac cgcccggcaa 270721 gagaacaaga ccagatgcaa atgcagtgag gactaagccg ccttgcagat acatcggcag 270781 aagcagcata gatgacagaa tgaccatcat acaaatgaac accatgatca cacccaaaat 270841 aaacatcggg tatttgaacg cacggaggtt catcataggc tgcttcattg tcagctggcg 270901 gattgaaaat aagataaggc cgacaacgcc gacaatcagc gacacgataa cagtcgggct 270961 ggaccatccc ccggagcctt cacccgcgtt gctgaatccg aatacaatgc cgccgaagcc 271021 aatcgtcgac aggatgatag acaatacatc gattttcggc tttgtcgttt cagatacatt 271081 ttgcatatat gcgataccga aaacaagcgc cagcacaagg aatggaagag agatccagaa 271141 aatccagtgc cagttgagat gctccagaac caatcctgag aaagttgggc cgatggcggg 271201 cgcgaacata atgacaagcc cgatcgttcc cattgcggca ccccgtttat gaggcgggaa 271261 aatcaccaag attgtgttaa acatcagcgg cagtaaaaga ccggttccaa gtgcctgaac 271321 gatccttgcc gctaataaaa acgagaagct cggcgcaagc gccgcaatga atgtacctaa 271381 aattgaaaag ataagtgaca cggtaaaaag ctgtcttgtt gtgaaccact gcaacagcag 271441 tcctgaaaca ggaacaagga taccgagtac aagcaggtag cccgtcgtta accattggac 271501 ggttgccgct gtaatgttca attccttcat aaggtcggtt aacgcaatat tcagcgctgt 271561 ttcactgaac atgccgataa aaccggccaa cagcaaggaa atcataatcg gcatcacttt 271621 gtattgctga gatgctttag ctgttgtttc caaaatcatt tcccctctct atcaactgca 271681 tgtagtatgt cgtttttttt atctcttcag caggtcagga atgcagctgg agatatgaag 271741 gagcggcgta ctgttttttg ccgtcaaaga taaaaggatg ccgccttcaa tcatcgcgtt 271801 aaccacagtg ctggcttctt ttgcacggct ctcgctgcag ccagtctgcc gcagtttttc 271861 ctcatacaca gaggcccatt ctttgtaggc ttcatgacag gcttcgcgca acggttcgct 271921 tttcaatgac gtctcagccg ctagcaagcc cacaggcaag ccttcaatgt cttccgtaca 271981 tgaaaactgg caggagagct ccttcaaaaa ggcttgaatg ccttccgctg gatcggtgca 272041 ggcttccatg cagtccgcga ttttctgacg gatatactcc ttcatctcat tcacggcttc 272101 gatcgcaagc tgttctttac ccccgggaaa gtggtagtaa agagagcctt taggcgcgcc 272161 gctttccttt ataatctggt tcagccccgt gccgtaatac ccttgcagct gaaaaagccg 272221 ggtagctgcc gaaaggattt tctcacggga atctccataa ctcataacat tcccacctta 272281 ctgaattgca atcaaaaata tagtgactgg tctattatct tgattcaatc atcaattgtc 272341 aagaaaaatt cattgtatga aaagacaaaa aaagaaggat atgacaacaa aaaatactga 272401 gagaaaagct gactgatctt ttgactgaat agataaaatg tacaatgatt aatcatcata 272461 tggatgtaag gagagaaata gatgaaaaaa caacgaatgc tcgtactttt taccgcacta 272521 ttgtttgttt ttaccggatg ttcacattct cctgaaacaa aagaatcccc gaaagaaaaa 272581 gctcagacac aaaaagtctc ttcggcttct gcctctgaaa aaaaggatct gccaaacatt 272641 agaattttag cgacaggagg cacgatagct ggtgccgatc aatcgaaaac ctcaacaact 272701 gaatataaag caggtgttgt cggcgttgaa tcactgatcg aggcagttcc agaaatgaag 272761 gacattgcaa acgtcagcgg cgagcagatt gttaacgtcg gcagcacaaa tattgataat 272821 aaaatattgc tgaagctggc gaaacgcatc aaccacttgc tcgcttcaga tgatgtagac 272881 ggaatcgtcg tgactcatgg aacagataca ttggaggaaa ccgcttattt tttgaatctt 272941 accgtgaaaa gtgataaacc ggttgttatt gtcggttcga tgagaccttc cacagccatc 273001 agcgctgatg ggccttctaa cctgtacaat gcagtgaaag tggcaggtgc ccctgaggca 273061 aaagggaaag ggacgcttgt tgttcttaac gaccggattg cctcagcccg atatgtcacc 273121 aaaacaaaca caactacaac agatacattt aaatcagaag aaatgggctt cgtcggaaca 273181 attgcagatg atatctattt taataatgag attacccgta agcatacgaa ggacacggat 273241 ttctcggttt ctaatcttga tgagctgccg caggttgaca ttatctatgg ataccaaaat 273301 gacggaagct acctgtttga cgctgctgta aaagccggag caaaggggat tgtatttgcc 273361 ggttctggga acgggtcttt atctgatgca gccgaaaaag gggcggacag cgcagtcaaa 273421 aaaggcgtta cagtggtgcg ctctacccgc acgggaaatg gtgtcgtcac accaaaccaa 273481 gactatgcgg aaaaggactt gctggcatcg aactctttaa acccccaaaa agcacggatg 273541 ttgctgatgc ttgcgcttac caaaacaaat gatcctcaaa aaatccaagc ttatttcaat 273601 gagtattgaa gaaaagaagg cgaataagcc ttcttttttt tggcttttta ggaccaataa 273661 tgacctctga atcttaaaat ttctttaaaa ataagccaaa attacccttt acttaattaa 273721 tttggtaacg taatataatt ggagaatttg ttacaaaaaa aggaggatat tatgaaattt 273781 gtaaaaagaa ggatcattgc acttgtaaca attttgatgc tgtctgttac atcgctgttt 273841 gcgttgcagc cgtcagcaaa agccgctgaa cacaatccag tcgttatggt tcacggtatt 273901 ggaggggcat cattcaattt tgcgggaatt aagagctatc tcgtatctca gggctggtcg 273961 cgggacaagc tgtatgcagt tgatttttgg gacaagacag gcacaaatta taacaatgga 274021 ccggtattat cacgatttgt gcaaaaggtt ttagatgaaa cgggtgcgaa aaaagtggat 274081 attgtcgctc acagcatggg gggcgcgaac acactttact acataaaaaa tctggacggc 274141 ggaaataaag ttgcaaacgt cgtgacgctt ggcggcgcga accgtttgac gacaggcaag 274201 gcgcttccgg gaacagatcc aaatcaaaag attttataca catccattta cagcagtgcc 274261 gatatgattg tcatgaatta cttatcaaga ttagatggtg ctagaaacgt tcaaatccat 274321 ggcgttggac acatcggcct tctgtacagc agccaagtca acagcctgat taaagaaggg 274381 ctgaacggcg ggggccagaa tacgaattaa tgaaaaacaa aaccttgaag aatgctattc 274441 ttcaaggtta ttctgctttc agcacaatgg ttttcgcagc catatcatga acggtttgtt 274501 ttttcttcgt aaatgcggca gtcaaataga tcaggcggga gaacacatgc acccacgcta 274561 tcaggtaacg gacaatggct tgcgggaagg atattttttt atatgtttcg tccctcacga 274621 tttgcagccc gatgattttt ttgcctagtg tgcccttcca atttgtcagc ggcatcagca 274681 aagggtacac aatcagcatc aatatggcga caataatgac accggcggac ccatcgccaa 274741 acgtaaatcc ggctgccaaa atcactgctg cggcaatgat tacatcaagt aaaagagcgc 274801 aggcgcgcag catgaaacca gctagttcca atagaaacac tccttaaaat gttaaataaa 274861 cacctaatga ttgtaaaaaa gaagggccta aagtgggaat aggtgataag ccttaaatca 274921 caaaagttgg tgaaaatgtc ataggtaaat tggcataatc agccagctta tcacattacc 274981 aaattctttt ttagcccgaa accaagccct cagaagttat ttttgttaaa atagaaaagt 275041 tacaacagaa ttcggagggt ttattgtggg aaaagtgaaa cgaaatgccc cttgcccatg 275101 cggcagcggc aagaaatata aaaaatgctg cggaagtaaa gttgtcgact tcccggcgga 275161 actagcggca aaagaagcga aacaaattca ggaagactta gtggagtatg ccttcacagt 275221 acatagagaa agcatttcag gctttatcaa ccagcatgat tttctttctg ctatggacag 275281 acagacgaaa gacatcagcg tatttaactt aggaatctgg ggaatcttct tccacccgct 275341 tgctggtgag aagacaatct tcgaagagta ccttcagaaa aaaggcgatt cgatcactcg 275401 tccgaaaacg cgtgagatcg tagaatcatg gcagagcatg acgcctgctt tattgctgct 275461 gaaggacctg aaggaaggca tcattcactt tgaagatgtc attacggcaa aacaattcga 275521 agtggaaatg gacgccagca atcaagacct tcctccagtg ggaagcctga ttcttggata 275581 cccaatccac gaagcggaaa aagcagaatt cttcatgcag ttcacgatct tcccggtgaa 275641 gagaacagaa gcgctgatca gcaaggtgaa gaaatatgcg gatgccgctg tgaaggacgg 275701 caaaacgccg gaggacttca tgaagcagga attcaacaac gttctgttcg cgttgttagc 275761 tgagaaagat gaagagccac aagcagagaa agcggaagta agcactgttg agtgggcaaa 275821 cgacttggag aaagaaaccg ctgcggctat tgaagaaggc atgagcgggg aagagtatcc 275881 gactgaattg atcccagctg ttattgacat ctggaaaaca ttctgcgaga aaaaatcacc 275941 tgtcatcaga aagccggaag cttttgcggc ggcagttgaa tattatgtaa acgcaatttc 276001 tcttaacggc gcgtccgttt cccaggctaa actggcgaaa aaatacggcg ttagcgcatc 276061 aacgatttcc agccgttaca aagaaattga aagcacgctg caagatgaag cagatcgttt 276121 tgcacaagcg ttatcctcat aatggaaaaa accttgaaaa gccaggcttt tcaaggtttt 276181 tttatttctg aaacggaatt ttgatttcta accggaagat ggggtggcgg taggtaaaat 276241 ccagcctgcc aaaagcgccc ttcaccagtt tttgaatgat atatgtgccc atgccttcat 276301 gagcgccgtt tttcgttgag cggccaaacg attgataaat tgtatcgagc acttttgggt 276361 ccatcccggg agtgctgttt tcacaagtca gtacataaag cccgctgcgc agtgaagtct 276421 ccagtttaat ctctgctttt tctcgggcct ccgccgcgct gtcgagcgca ttttctaata 276481 tgttgccgac caagctgacc tgatcagcag gcgaaaacgg aagggaagaa agcggtgtat 276541 gcatatgcag cgaaacactc acattcgagg cgcgggcttt ttctaaaaaa tcataaagca 276601 cccctgcaac gtacgcgttc tctcctttca aaaaacggtc atattggctg tattgatccg 276661 cccagttttg aatatatgct tgtgtatctg ccttgggctg agctgatttg attgcagtga 276721 tatgtttcat tgtgtcatga ttccggcttc tgacatcaat cagcatttga ttggcgtgct 276781 gttcagcttg agtcagctta tcaatttgat cagaaagcct tgcctgcaaa gcagactgtc 276841 cgatacggag cccttcacac cctgcaaata tcgcgattac acataatacc ggcatgatgt 276901 ctgtgccaat caacaccact cccaccgaca tcacttgaat caccgcaatc cacgcacaaa 276961 gccctgagga acagtgtttc cacacccgct tcgtattcca aatgtacaat cctgcagcag 277021 ctgcgcctaa agcagcggcg agccaagagg cggctgtgct gtgtgaaaaa gcagcagctc 277081 cctgataaca tatgaaacta aataaaatca gataaagaca ttgaaaaagg gtaatcacgt 277141 actaaactcc tcaaaaatag tagttttgaa aataatcaag ctgctgctta gtgatcatcg 277201 cttttttaga cgttccctca aaggaaactg tgaatgaatg cttggtataa gcggaaaaat 277261 gctttatgta atgaatgttg ataataaagg aacgatgcga acgaagaaaa tctttttcgg 277321 gcaggtcgcc tttaatatca tttaatgttt gatacgtttg cacctcttcg gcggttgtca 277381 caatcgtcgt cgaacgtccc gtccgttctg cgaaaataat atccttcttt tgcaggacgt 277441 gcatttcaga cttttgcttt atcaatatac gcccattcaa actcgtttcc gttttctttt 277501 tcaagtaccg gtcgaaggaa gcggccagac ggtcggcata gtacggcttc ataatataat 277561 catggacgtt caggtcaaag gcgtgaaccg cataaccgcc gtggccggta acaaaaatca 277621 catccacatc aagtgaatgg gatttgatca aatcagcaag ctcgtagcca gacatatggg 277681 gcatctcgat atcggcaagc agcagatcaa tgtctccgtt ctttacccgc ctgtaggctt 277741 ccttcgctga atcggtggaa aagacaattt cgacgtcctg cattctggac acgatcgctt 277801 ctaacttctc taaatctact cgataatcat ctacaagtcc gacttttacc attatcattc 277861 ccctagttac atagaatcat ctttattcta tcccatttca cgacataaaa agaactcttc 277921 gcgacaactt tatccaacta atccagcttt tcgtatatag tcattactag aaataaagat 277981 aagggagatt gtgacatgat tacactgacc gattgcagcc gcaggtttca ggataagaaa 278041 aaagtagtca aagcggtgcg agatgtaagc ttaacaattg aaaaaggaga agtcgtcggc 278101 attctcggag aaaacggtgc cggcaaaacg acgatgctga gaatgattgc ttccttgctt 278161 gaaccatcac agggtgtaat cacagtagac ggctttgaca cggtcaagca gccggctgag 278221 gtcaaacaaa gaatcggtgt cttattcgga ggagaaaccg ggctttacga caggatgacc 278281 gctaaagaaa atctccaata cttcggcagg ctgtatgggc tgaaccgcca cgagatcaaa 278341 gcaagaatag aagatttatc gaaacggttc ggcatgcgcg attatatgaa ccggagagtg 278401 ggcgggtttt cgaaaggcat gaggcagaaa gtcgccattg ccagagcgct gattcacgat 278461 ccggacatca ttttatttga tgagccgaca actgggcttg atattacgtc aagcaacatc 278521 ttccgcgaat ttatacagca gctgaaaaga gaacaaaaaa cgattctttt ctccagccac 278581 attatggagg aagtgcaggc gctctgtgac agtgtcatca tgattcacag cggagaggtg 278641 atttaccgag gggcgcttga atcactatac gagagcgagc gcagtgagga tttgaattac 278701 atctttatgt ctaagcttgt cagggggatt tcttaaatgc tgagccatat ttataaaaaa 278761 gaaatgatcg acgctttacg cgacagaaaa acgatattac tcacaatctt agtgccgatg 278821 attatgatgc ttggacttgt ctttttttat gaaagcatgc tgtccgacaa aggggagcag 278881 tacacgctgg ctgtcggcca ttcgcttccg cccgcactgg aaagcaagct taatgagatt 278941 gacgaaatca gcgtaaaaac atttgcaaag cctgaagagg cagttgatga aggaaaagca 279001 gatgcctatc tgaacgtccc gaaagagttc gactcatatg tcaacagcat gacacctttt 279061 aaggttgatg tttacggcaa ttcaatcgat caagggtcgt caaatgccat gcagcttgtg 279121 cagtctgcct tagatcagta caaaaatgaa attgtgcagc aacgtttaac aaataagcat 279181 attgatcaat cggtgatcca gccgtttaca attcagcaaa aggaagcgga tgaggagaaa 279241 gggacttccg ctattatgct ttccgccatt ctgcccatgc tgattctgac ttccattgtt 279301 tccggcgcaa tgccgatcgc tcttgatatc atggccggtg aaaaggaccg aaagtcaatc 279361 gaggcgctgc tattaacgcc agtcagcaga aacaaagtgc tggtcggcaa gtggcttgcg 279421 gtttccactt ttggcgtggc ttcaggtgta tttgctttgg tgtttttgat tttgtccacc 279481 gtgttattta ccgaaaattt aaaaacggcc ttccagctgg gagatcatat gtggagtgta 279541 atcggcgctt cagccttaat cattgtgctc tctgcattgc tgatatctgc gatggagctt 279601 ttcatcagca tcatgtccag ctcggtaaaa gaagcgcaaa gttatatgtc tctcgtcgtc 279661 tttctgcctg tgttcccgat gtttttcatc ttcagcaagg caccgaacca atttgactta 279721 tcatactttc tcatcccgtt tctgaacctg catgcgttat ttaaacagct tttattcggg 279781 atggttgacc cggctaccat tttgtctacg tcaggaacca tcgccgtgct catcgccatc 279841 ttctttttac tagccagagc ctgcttcctg aaagacaaat gggttcttcc aaaataaact 279901 tgcgaaagga gaaatacact ttctcctttt tgtatatcct gaaaaaagaa ggaaaataga 279961 aaaaggatat ctaatacaaa aagtgaccct gcactatttt tcatcaaaat tggtttcaaa 280021 ggagaaggaa caatggatca aacacgtaca ctcggcaaaa cgaagctgaa ggtgaagcgg 280081 atcggattcg gcgcgaatgc ggtcggcggg cataatctat ttccaaatct aaatgatgaa 280141 acagggaagg atttagtgcg cacggcattg gatggcggcg tcaattttat cgataccgcc 280201 tttatatatg gattggggcg atctgaagaa ttaatcggcg aagtcgtaca ggaacgcggc 280261 gtgcggaatg agctcatcat cgccaccaaa ggagctcata aagaagtgga cggcagcatt 280321 gaattagaca atagccggga gtttcttcgc agcgaggtgg agaagagcct gaagcggctg 280381 aaaacagatt acattgattt gtattatgtt cactttccgg atggaaaaac acctctcgct 280441 gaagtggcgg gcactttgaa agagctgaag gatgagggga aaatcaaagc gatcggcgct 280501 tcgaacctcg attatcagca attgcaggat tttaatgctg acggctattt ggaggtcttc 280561 caggccgaat attctctcat acagcgtgat gccgagaaag agcttcttcc atactgtgaa 280621 aaacaaggca tctcctttat tccttacttt ccgcttgcgt ccggactgct gacaggaaaa 280681 ttcacgcaag acacagtctt tgatgatttc agaaaggata aacctcaatt tcagggtgaa 280741 acgtttatcc acaatctcaa aaaagtagat aagctgaaag cagtagcgga ggaaaaacaa 280801 gcggatacgg cacatgtcgc cttggcgtgg ctgttaacga gaccggcgat tgatgccatt 280861 attccaggag ctaaacgacc ggagcaatta caggataacc tgaaaacctt gaacattgaa 280921 ctgaccgaag atgaagtgaa tttcatcagc gacattttca aataaaaaag gaaatagccg 280981 tcatggctat ttccttttgg tgttttattc tttgatgaat gcttcgacta attctgctgc 281041 tctgtaatca tccatatcaa gctgccattg gtcgatgtca tttttcttca ttttcacttc 281101 aactgttttt tcagatgaag caggtccaag ctttttgaat tcctcaggat agacttgaag 281161 cgcgtatttc actgcctctt catagctggc actagagttt ttactgtagt agtctttcac 281221 tttgtcttcg atgcggtctg aaagagaaga tgcatctaca ggtttaactg tggcttcaac 281281 aattgcttcg tctttagaga ttgaagtcgt ttttgcttga atggaagagt ttttgcttaa 281341 tccctcttta atgccgttca cgatattatc aagcgctttg ctgtccgcat atgtgctgga 281401 aaggccggaa gctgagagat aaccgtcttt ggctgattca ttaaaatcat ttacaatttc 281461 atttttgtta gcgccggtga ttttttcgaa atcggcgtta tctttgccga aaagaaggac 281521 atcaacataa gctgataacg cttttgcaga atcttggagc ttatctgccg tcgccaggat 281581 ttttttgtct tttccgtcaa ttttaaaagt aactgatttt ggctttttat caccgtaaga 281641 ttccggcgta tagttaagct cgtattgctt gcctttatct acaacgaaga aaagatttcc 281701 ttcaacggat ttgtcagcgt taatcgtgct gccctgaagc ttttcgctat agtcttcagg 281761 gtctgtgtca gacattttgg tatcaccttg atacaatgtg aaatccatac tgtctacatt 281821 cagcgggtct tttcctgtgt ttttcaccgc gacattgact tttaacacaa gctggtcatc 281881 tgaagtggac ttatcatatt tagacggaag tgtgtaagag acatccttga ttttgacttg 281941 agctatatct gagctttttt ctgtttctga ttctttcttc tccgcgcttg ttttgctgcc 282001 ggaacaagca gctgtaaaca tcatcagcag aagaattagg aaaacagcgt acgttttttt 282061 ctgaaacatt catttttcct cctcaaatgg tttaggaaag gggagtcttt tgtctttgag 282121 aaatggatct ttttgaatgg attagcatca tataaccaaa aaaatcagtt cttttctcac 282181 ggttttcacc ggattttctg gaaactccgc cctcctttgt catgaatgga cctataaaaa 282241 gttacaacgg aattaatttt aagattatta gcttttatat tgaataggtt catcatccta 282301 tttttggtga aaaatgttct ggtaaaactg gtaaactcag aaaactgtgt attttagact 282361 attacttttt gattagttgg agggaactta agaaggatga aaggggccgc ctttgtgaag 282421 aaagagggac tgaaacaaaa agcactggaa atcggccggg tgccgacaca cttaaaactg 282481 gaaattgaag attatggcgg tgatgataaa agagctcatt tttgttgggc agatcctcag 282541 gatgagaata ccggcattat cgtggagctt ggaccggacg gagagctgga atccctttcc 282601 cgtgatattg agcctgaaag cggagaaagg ctgtctgagg agaaactaga ggatatcatg 282661 cgccaatttg tcgagactca tcatccgggg gcactctctg cctttgttcg tgaagaaaat 282721 gaccgtgcat acggcgataa agtgagattt tcatatgttc aaatggaggc tgggcttcct 282781 ctccccatga gcggatttat ggctgatgtt tccttatcag gtgagattgt ttacttccgt 282841 tattacggcg aagcgggcag catcatcaag ccaaagcggg tcgcggatgt tgaagaggca 282901 cttgccttta tcaagaagga cgtggagttc gaccttttgt ttgaggttct ccatcgttct 282961 gtttacaaaa acggagatga tcagccgcat ttggtgtacg agcctgaagg tagggcgatt 283021 accgtacctg cggatttggt tcaagaagaa caagcagttg atgatgacga tgattacagg 283081 gagccggaga gctttcctct ccctttattc gagggcatcc gcgaaaaggc cgatcctgac 283141 agcatgattg gtattgaaaa tgggtttgtc aaagagcggg aagcggattt gggagatggg 283201 agaattggaa tcgtttggcg gaatccggat gaccctgtgt atcagccggc ggataaaagc 283261 atggacagct ggtttaaggg acggactcat caagtgctga aaaccatcta taacaaagaa 283321 accggaaaac tcgaaggcgt catgtcattt atggagaaaa aagggccgct gacagtaacc 283381 ttggcagagt gtgaaaaaat cgcgcttcgc tttctatttg ctttatttcc gaatgccgat 283441 caatatttta ggatcagata cgacgaaaaa gatgaagaag aaaacgcagt cgctggtttt 283501 acgtttgaag cgcattgtca cggagttccg ctccgatttg ggcagatcag aatttgtgtc 283561 agccgccaga cagggtatat caccgtttat atgggaccgg atattgaccc aaataagctg 283621 gcaaccattg atcctgtgcc ggctatttca gttgaacaag ccaagtctat cttttggcag 283681 cattttaaag ttgagcttgg ctgggaaaga gagtacgggg atgatgaaga acacagctac 283741 cggctcgtct ataagccggt gtatccgcat tttatcgatg cacatacagg ggagcctgtc 283801 ttcagcatat ggtgaaacag ccaaaagtca cgcaattgcc tcagatatag aagagagtat 283861 gtgatgaaag taacagaaag aatctcaaaa aacaatgaca ataatagaaa aggacctttc 283921 ttcactttaa atgaagaaag gtctttttat ataataaaca ggattctctt tgtcgtagac 283981 tctttgaaag ggatgacttc attggttaat aaacagctga aaaagaaggc gcaggagatc 284041 ggaaatgtac cgacgcatta tgagcttgag atagaagatt acgaccaaaa gcaaaagaag 284101 tacgggcagg catattttat ctggaaggac cctaaagatc cggaaaagca cattacagtt 284161 gaacttagaa atgacggcgc cttgctcacc ttttcaacaa ctgtccactc cgagacagac 284221 aaaaaacttc cagatgccga gctgaagctg acggctcttc agtttgccgc tgccaatcat 284281 cccggcacat ttatgaattt tcattttcaa ggcaaggaag aaagggggca gcacatccgg 284341 tttgtctata ccaaaatgga gctggggctt ccgattccca attcaggctt tttaattgat 284401 atgacacgaa gcggtcagat tgtccacttt ctatattacg gggaagggca taaagccgaa 284461 gttccgacgg aatttgtagc aaaagagaag gttgtatccc attacttaaa cacaatgtct 284521 tttgagctga tgtacgatgt cattgatggc gaacaggaac caaggcttgt atatgaaccg 284581 attctaccgg gatacagcta tcccgcagat gtagacgaaa ttgtgcccga ccagcatatc 284641 gcagatgaaa gaatagaaaa cacggcgcca ctgccgccgc ttcagaacaa ggaagaagtt 284701 gatatatttg ccttgctggg ttttacctct gatatgcaga aagtcagtga aagagacttt 284761 ggagaacaaa ttggaagcac gtggcgcagg ggcgctgcgc cggagcgtaa ggatttaagc 284821 ataggaagct attttgaaac gagaaataaa aatacaatca aaatgaagac ggataaaaga 284881 accggaaaat taaaagcagc gctttctttt atggactggc ggaacaacct ccaatgctcc 284941 acggaagaat gccaagagat agcgcttcaa tttttgtatg ccctctatcc gagagcggct 285001 gagtttttca gggtgaatcc cgtccgaatt gatgaaagag ggagagtccg caaccatttt 285061 tctgtctggt ataaaggagt gccgctgcgg ttcggcgctg cccgcatcat tgtcaatccg 285121 gaaactgggt tgattgacgc ttttatggcg cctgatattg aacctgaaca attggaagcg 285181 ataaatcaca ggccggatgt ttccgctgaa gaagcgaaag aagcattttt agccgctttt 285241 gatgtgaaac tggaatggca gcctgatttt acagcaggca gtgaccagca ctgcaaactt 285301 gtctataagc cggtttaccc ttcctatatt gatgcgcaca taaggaaaaa gaaaaggctg 285361 tgaggggtgt ctagttagga atcatctcca agtgggggta gtccttgaat cgtttccaat 285421 ccccgcccca ttcgaaaccg agtgtcttag cgatctcgac aacctccagc caatctgatt 285481 ttccgttttg attgccgtca tattccatat cccatatgat gctgccatcc tttttttgaa 285541 gggcgaaatc aatcgctaaa ccatagttat gatacgattc ccctcctctt gcataggtga 285601 caatattccc tttttttgta cgtccctgtt tatataattc atcttgttcc ttaaaggacc 285661 tgaatccttc agtaatgacg acgtcaatgc ctttattcgc tgcagcggct ttgagtgcat 285721 cggcattctg cttcacaatc ggatgaagat ccgaggggac aggcatgtcc tgcaaggcgt 285781 tttgagaatg ccattcatgc cgaatataac taaaacaaag atctagaaga aatagaatac 285841 ataagataac aaatgttttt gcgggtaagt tcatatcggt ctcactttct caagatgtgc 285901 tgaatgttaa cgcttttaag tgattgactc tctctaaaag cgaacagcta tgataaaata 285961 taacataaat agtagcagga ggaaggaggc agaccgatga gagcaaagat tccatcagaa 286021 gaagtagcag taaagctgaa tgaatggtac aagctcattc gcgcatttga agcagatcaa 286081 gcagaagcgt taaagcagga gattgaatat gatttagaag atatggaaga gaatcaggac 286141 ttgcttttat atttttcttt gatggaattc cggcatcgaa tcatgcttga taagctgatg 286201 ccggtgaaag acagcgatac caagcctccg ttctctgata tgctgaacga aattgaaagc 286261 aatcagcaaa aactcacggg cttactggaa tactactttt attatttcag aggaatgtac 286321 gaattcaagc agaaaaattt catattagcg attgaccatt ataaacatgc cgaggaaaag 286381 ctcgagtatg tcgaggatga gatcgaaaaa gctgagtttc tttttaaagt cgcagaagtg 286441 tattatcaca tcaaacaaac gtatttttcc atgaattatg cgagccaggc gcttgatatc 286501 tatacgaaat atgaactgta cggtcgccgc cgggttcagt gtgaatttat catcgccgga 286561 aatttgaccg atgtgtatca tcatgaaaaa gcactgaccc acttgtgcag cgctttagaa 286621 catgccaggc agcttgaaga agcgtacatg atcgctgctg cctattataa tgtcggacac 286681 tgtaagtaca gtctgggtga ttacaaagaa gcggagggct atttcaaaac agccgccgcc 286741 atttttgagg agcacaactt tcagcaagct gttcaagctg tattttcact gacccatatc 286801 tactgtaaag agggaaaata cgacaaggca gtagaggctt atgaccgcgg gataaagagc 286861 gcggctgaat gggaggatga catgtacttg acgaaattcc gcctcattca tgagctgtat 286921 cttggaagcg gcgacctgaa cgtgcttaca gaatgctttg acctgctgga atccaggcag 286981 cttcttgctg acgccgaaga tctgctgcat gatacagcgg aacgtttcaa tcagttggaa 287041 cattacgagt ccgccgcttt cttttaccgc aggctgatga atattaaaaa gaagcttgcc 287101 gagcagcgtt ttcaatagga aatggcagag aactacaggt tctctgcttt ttttgtgctg 287161 ttttcaactc ggaaaaacag ggtattttcc actgcatagt gagaaacaga ggaggatatc 287221 aagtatgtac aaagatttaa ccggaaaaac agcgattgtg acagggtctt caaaaggaat 287281 cgggaaagcc attgcggaac ggttcggaaa ggagaaaatg aatgttgttg taaattacca 287341 cagcgacccg tctggagcag atgaaactct ggaaatcatt aagcagaacg gagggaaagc 287401 cgtctcagtt gaggcggacg tgtcaaaaga agaggggatt caggcgctct tggacacagc 287461 tttagagcat ttcggcacgc tcgatgtgat ggtaaacaac tccggtttta acggcgttga 287521 ggcgatgccg catgagatga gtcttgaaga ttggcagaga gtgattgatg tcaatgttac 287581 cggaaccttt ctgggagcga aagcagcact taaccacatg atgaaaaaca atatcaaggg 287641 caatgtgctg aatatctcaa gtgttcatca gcagattccg cgccctgtaa acgttcagta 287701 ttccacatcc aaaggcggca tcaagatgat gacggaaacg ctggcgctca attatgcgga 287761 taagggaatc cgcgtcaatg cgatagcgcc cggcaccatt gccacagaat caaatgttga 287821 tacgaaaaag gaagagagca ggcaaaaaca attgaaaaaa atcccgatga aagccttcgg 287881 aaagcctgaa gaagtggcgg cagcagcagc ttggctcgta tctgaggaag caagctatgt 287941 gaccggcgca acacttttcg tcgacggcgg aatgacactt tatccatctc agcttgaata 288001 gaagacaaaa cagggggatt gcgggatgaa aacagactgg tggaaggatg cagtggtgta 288061 ccaaatttac ccgagaagct ttcaggacag caatggagac ggaattgggg acttgcgggg 288121 gattatttcc cgtcttgact acataaagga gctcggggca gatgtgattt ggatttgccc 288181 gatctatcct tctccgaatg ttgattacgg ctatgatgtg acaaaccata aggcgattat 288241 ggattcttac ggaacaatgg acgattttca cgagctgctg gaccaggtgc atcagcgggg 288301 attaaagctg gtgatggact ttgtgttaaa tcacacctcg gtcgagcatc cgtggtttaa 288361 agaagcggag ctggacaaaa acagcaaata ccgtagctat tattattggc gtcccggcac 288421 aaagaacggc ccgccgacgg actggctctc aaactatgga tgcccggtct ggcaatacga 288481 agagcacacc ggagaatact atctccatat gaatgccgtc aaacaagctg atttaaactg 288541 ggaaaatccc gaagttcgcc aggcggtgta tgacatgatg aaattttggc tcgataaagg 288601 ggtcgacggt ttgcgaattg atcagctcca tctcatttct aagaaagaat atcttccttc 288661 gtatgaggac tatatcaatc agcaggcaga gccgaagccc tttcagccaa atggcgaacg 288721 aatccatgac tatttaaaag aaatcacaga tgaagtgttt tctcattatg atgtcatgtc 288781 tgtcggagag gtcggcagtg tcacaccgga agaaggcctg aaatatacgg gaacagataa 288841 gcatgagctg aatatgattt ttcactttca gcatatggag cttgatcagc agcccggaaa 288901 agaacattgg gatttgaagc cccttgagct ttctgattta aaatcggttt tgacaaaatg 288961 gcaaaagaag cttgaacatc aaggctggaa tacattgttt tggtgcaacc acgaccagcc 289021 ccggattgtg tccagattcg gagacgatgg ggaataccgc aaagcatcag cgaaaatgct 289081 ggcagccgta atttatttta tgaagggcac gccgtatatt tatcagggag aagaaatcgg 289141 gatgacaaac gcgccgttca cccggattga agactacaaa gatatccaaa cgatcaatat 289201 gtatcataaa cgggtgtttg aaaaaggcta tgatccaaat gatgtgatga gatcgatctt 289261 agccaaaagc cgggatcacg cccggacccc gatgcagtgg aacagcggca aaaatgccgg 289321 atttactgac ggcacgcctt ggctgaaggt caatccgaac ttcaccgcaa tcaatgtgga 289381 ggaagcgcag ggagatcctg attctgtctt aaactattac aaaaagctga tcagcctgag 289441 aaagcagtac gctgacctca tgaaagggag ctttgatctt ttgcttccgg acgatccgca 289501 gttgtttgta tacatgagag aaaacagtaa acaacagctt ttgtcggtca ataatttttc 289561 aaaagagcag gctgtttttc agtggcctaa gaactgcggc aaagctcagg cctcactgct 289621 tctcagcaat tataacaacg atgatcttga tgacgaaatg gtgttccggc cttatgagag 289681 cagggtctat cttctggaca aaacaaacta atgattgaag tagcccggca tttttagccg 289741 ggttttttta gtacatatat tcgctctgca ggcgggaaga ataaatgaaa atgaaattta 289801 ttcttgcaaa acgtaatgac ttcggtttat tatgatatag gattacaaaa tcgttatcat 289861 tttgatttaa agttactgaa aaagagggga tatacgatat gtttaaaaaa tggagcggtt 289921 tgtttgtgat tgcagcgtgc tttttattag ttgcagcatg cggcaactca tcaacaaaag 289981 ggtcggcgga ttcaaagggt gataaactgc acgttgtcac aacgttctac ccgatgtatg 290041 aattcacaaa acaaattgta aaagacaaag gcgatgtgga tctgttaatc ccatcttccg 290101 ttgaaccgca tgattgggaa ccgacgccga aagacattgc caacattcag gatgctgatt 290161 tgttcgttta taatagtgaa tacatggaga catgggttcc gtcagctgaa aaaagcatgg 290221 gccaaggcca tgccgttttc gttaatgcaa gcaaaggcat tgatttaatg gaaggctctg 290281 aagaagaaca cgaagagcat gatcatgggg agcatgagca cagtcatgca atggaccctc 290341 acgtatggct tagccctgtt ctggcacaga aggaagttaa aaatattacg gctcaaatcg 290401 tgaagcagga cccggataac aaagaatact atgagaaaaa tagtaaagaa tatattgcaa 290461 aactgcagga tcttgataaa ctatatcgta caaccgcaaa aaaagcggag aaaaaagaat 290521 ttatcacgca gcatacagct tttggctatc tggcaaaaga atacggcttg aagcaggttc 290581 cgattgcagg gctttcacct gaccaagaac cgagcgcagc cagcttggca aagctgaaaa 290641 catatgccaa agaacataat gtaaaagtta tttactttga agaaattgca tcctcaaagg 290701 tcgcagatac gctcgccagt gaaatcggcg cgaagacaga agtgctgaat acactggaag 290761 gcttgagcaa agaagaacag gataaaggtt tagggtatat cgacattatg aaacaaaacc 290821 tcgatgccct gaaagattca ctattggtta aatcataaga tagtgtgcgc cggaggggtg 290881 cacactattt ctttgtgaga aaggaagatt aacatgaatc tcgtctcatt gaaagatatc 290941 gttttcggct attcccatac gcctgtttta gataaagtat cacttgatat tgaaagcggt 291001 gagttcgtcg gcatcactgg accaaacggc gcctctaaat cgacgctcat aaaggtaatg 291061 ctcggcatgc tgaaaccgtg ggaaggcaca gtgacgatca gtaaaaggaa tacagaaggg 291121 aaacgcctga ccatagggta cgtcccgcag caaatttctt catttaatgc cggatttccg 291181 agcacggtgc tggagcttgt tcagtcaggc cgctatacaa aagggaaatg gtttaaacgt 291241 ttaaatgaag aagatcatct tgaagtagaa aaagcattga aaatggtgga aatgtgggac 291301 ctccgccatc gtaaaatcgg tgatttatca ggcggacaga aacagaaaat ctgtatcgcc 291361 agaatgctcg ccagcaaccc ggatctgctg atgctggacg aaccgacgac agctgttgat 291421 tacgacagca gaaaaggatt ttacgaattt atgcatcatc tcgtgaaaaa tcacaaccgc 291481 acagttgtga tggttactca cgaacaaaac gaagtacagc aatttttaga taaagtgatt 291541 cgattagaga gaggagaaaa aggcggatgg aaatgtttga cttggaattc atgcgacgag 291601 cttttctagc aggcggcatg atcgccgtca tggctccgat actaggagtg tatctcgttc 291661 tcagaagaca ggccttaatg gctgacacac tttcacatat ctcattgtca ggtgttgcca 291721 tcggcttttt tctcagcacc aatataaccg cagcaagcat agtcgtcgtg accatcggcg 291781 cgatcggaat tgaatacatg cggcgggcgt atcggactta ttcagaagtg tccattgcca 291841 tcttaatggc agctggtttg tccttcgcga tgtttttaat cagcctttcc aaaggcacag 291901 ccaatatgag catcgatcaa tacctatttg gatcgcttgt gacagtaaac cagcagcagg 291961 tctatattat cagtattatc acactgctga tcctgcttta ttttattgta ctgagaaggc 292021 cgctctacct gctgacgttt gatgaagcta cagccaaaac atcgggaatc aatacaaacg 292081 ttctctcgtt gtcattcagt attgtcacag gccttgcgat ttcagtcatt attccgatca 292141 tcggggtcct tcttgtatcg gccctgctcg tattgccggc agccttcgcc atcagaattg 292201 caaaaggctt taacatggtt ttcattacag ccatactcat ttcattattc agcgtattta 292261 cgggactgac atcatcctat cagctcggga cgccgccagg tccgtctatt accctgctat 292321 tgatcgtttt gctattaatc ggatttgcag ttcagggagt ttggacgttt atcaaaaaag 292381 aagctcagcg caaaaaaaga agccgataac atgaaaagca gttttcccta gggaaaactg 292441 ctttttttat agaaacaatt cggcaaggcg ctcataagat tcttttttcg cctcaaaatc 292501 aaacacattg cacagaacca tgatttcatt tgtttcgtag cagcctgtga ggtctaacag 292561 ctgttgtttg acagtggtgg gagaaccgat caccatccgc tttctgtttt cttctatgag 292621 ttttttatcg gacgctgtat agggatgagc tttcgcttcc tcgatgcttg gcacgcggct 292681 gtccaagcct tttccgacgc gaagaagcca cagatcctgg cttaatgcga gttcttctgc 292741 ctcttcatct gtttttgcgc aaatgacaaa aatcgtaaac agtgcggatg gattcgaaaa 292801 atgggctgag ggccgaaagc tttcccggta gatgcggaat gcattttctc ctcgctcggg 292861 attaatgaaa tgcccaaata catatccaat cccctggtgc gccgcgcgtc ttgcgctgtt 292921 ttcaccaaga ccgagcaccc atagctcggg tgccgtacca ataaggggcg ccgctttgat 292981 tccggcatac ggatggtcgg gaggaaggga atctgttaga aaataagaga catcctgcag 293041 ctgtctgtta aattcggtta agcttttttt caccccgtcc gttaatgcaa gtctggtttt 293101 tgtcgtgccg ccgggggagc gaccgacgcc gaggtcaatc cggtttggat acagggcctc 293161 aagctggcga aaggtttcag ccactttaaa tgggctgtat tggggcagaa gcacgccgcc 293221 tgatccgaca cgaatggtgt ttgtctgtgc tgcgatgcgg gcgatcatga tttcaggcgc 293281 tgtgcttgcc agtcctttcg tgctgtgatg ctcggcaaac caataacgct tatagcccca 293341 ctgttcgctt aattgggcaa gctcaaccga atgctggaga gttgtcacag ggctttctcc 293401 tttagaaaca ggtgcctgat caagtatgct taaatgaatc aaaaggccgc ttcctttctg 293461 tctgttttta gatggtgaca ccagaatagg caaaatgact tgcccgcgtc aaatggtttg 293521 tttaagaagc gcactttata gcatttgcaa atcatatatc aaatatggaa gttttttttc 293581 gaggtttttc gtcaattatt cttaactttt acgaaacttt gatataataa caaacgtata 293641 tattagtaat ttacggctta ttttccttgt gagcgtaaaa ataaatgtga ctatcttcac 293701 attttgatga gtaggagtga atcgtgtggc aatttcttta gaaaaaggtc aacgaattga 293761 tttaacaaaa ggaaaagccg gtctgtcaaa attgatggtc ggtctcggct gggacccagt 293821 gtcctcaggc ggaggattct tcagcaaact gcttggcgga ggcggtccga atatcgactg 293881 tgacgcttca gtgctgatgc tggaaaacgg aaaattcacc gataagaaaa acctgattta 293941 tttcggcaac ctgaaaagcc gctgcggcgg tgtacagcat acaggcgaca acctgacggg 294001 tgacggtgcg ggcgatgacg agcaaattat gatagattta gataaagtgc ctggaaacat 294061 cgataagctt gtatttgtag tgaacattta cgattgtgtc agaagaaaac aagatttcgg 294121 catgattcaa aatgcgttta tccgcgtagt tgatcaatct aatcacgagg aaatgctcaa 294181 gtacaatttg agagacaatt acgccggcag aacaagcctg attacagcag aaatctaccg 294241 cagcggcagt gagtggaagt ttgcggcggt cggtgaaggc acaaacgata cgagattaga 294301 agatattatc agtcgatacg tataaaagaa aaggagtgga tgaaacatga caatttcatt 294361 ggcaaaagga caaaaagtag atttaacaaa aacaaatccg ggtctttcaa aggttgttgt 294421 cggtttaggc tgggatacga acaagtatga cggcgggcac gactttgatc ttgactcaag 294481 tgtgtttctg ttagacgccg cgggcaaatg cgcgtcacca aacgacttta ttttctacaa 294541 ccagcttgaa ggcggcaacg gttcagtcgt tcattcaggc gacaacctga ctggtgctgg 294601 cgaaggcgac gatgagaatg taaaagtaaa tctcagcgct gtaccggcaa acattgataa 294661 aatctcattt gttattacca ttcacgatgc agaagcgcgc agccaaaact ttggacaagt 294721 atcaaacgcg tttgtccgca tcgtaaatga agaaacaaat gaagagctca tccgttacga 294781 tcttgcagaa gatttctcta ttgaaacggc aatcattgca ggggagcttt acagacataa 294841 cggcgagtgg aaattctcag caatcggctc aggctaccaa ggcggccttg cccgcattgc 294901 aacagactac ggtttgcaag tcggttaaga caaatacgaa gagcagaaag gagagaggca 294961 gtatggccat tcaattatca aaaggacagc gcattgattt aacaaaaaca aatccgggac 295021 tgactaaagc ggtgatcggc ttaggctggg atacaaacaa gtactccggc ggacacgatt 295081 ttgacctgga tgcttcggcc tttttagttg atgcgcatga taactgcgta aatgatctcg 295141 atttcgtctt ctataataac cttgaacatc cgagcggcgg tgtcatccat acgggtgaca 295201 accgcacggg tgagggcgac ggagatgatg agcagattat cgttgatttc tcaaaaatcc 295261 ctgctcacat tgagaaaatc ggcatcacag tgaccattca cgacgctgaa gcacgcagcc 295321 aaaactttgg acaagtttcc aatgcatttg tccgcgttgt ggatgaagaa acgcagaatg 295381 agcttcttcg cttcgatttg ggagaagact tctccattga aacagctgtt gtcgtttgtg 295441 agctttacag acacggcggc gagtggaaat tcaatgcaat cggcagcgga ttttccggcg 295501 ggctggctgc attgtgccgg aattacggtt tgcaagtgta agcgagtgac aaatagagaa 295561 gtcaccgttt caaattatag gaggaaaaaa cttggacttt ttacatcata ttttgtctac 295621 gtatgcttca tttttcgatt ggaaaatgtg gggggaagtt ctgactgatc ctgtttcctg 295681 gggtttgatc ggttcccttg ttgttctgga aggcctttta tcggccgata acgcgcttgt 295741 tcttgcggtc atggttaaac acctgccgga aaaacagcgg aaaaaagcgt taacgtatgg 295801 tttgtttgga gcttatattt tcaggtttat tttcatcggg ctcggtatgc ttctcattaa 295861 attctggtgg atcaaggtgc ttggcgcgct ttacctggct tggctcgtca ttaagcactt 295921 ctggataggc gaaaaagaag aggaagcgga cggcatgaag aaaaactctt ggatggtccg 295981 cacgttcggg atcttctggg cgactgtcat ttcagtagaa ttaatggatc ttgccttctc 296041 tgtggacagc atcctggccg cgtttgcagt atctgaaaaa gtatgggtgc ttctgattgg 296101 cggtatgctt ggtattttaa tgatgcgtac agtggcaaaa gtgttccttg tgctgattga 296161 taaaattcct gagctggaaa acacagcatt cgtcttaatc ggcattatcg cgctgaaaat 296221 ggcggggagc gctttccatt acgaaatgcc gcactctgta ttcttcatta tcattatcgc 296281 tgcatttgcg gtaacattga tcattcacta catcaataaa caaaagcagg tgcgcgaaca 296341 aacagccgct tcaaaagaag aataaaacaa aacaaggagg gaggttcaat gtccttcctt 296401 ttttgttacc gaaatatcgt ttcaatgaca aaccggaaag gaggatatga tgagacaaga 296461 agaactaacc attcataaag cacttccggc tgatggcgat tggaaaagcc tgctgtttca 296521 gccattgccg gagcgggatc actatgaaac tgcacaaggc ctttcttttt ctcgtcttgc 296581 cggtcagata ttgggcacgc ctattgatga gacggactac tataacgagc tgtatgagct 296641 gtctgtaaac gaccgcataa cgattttgag tgaaacgctt gataaaacaa tcgaaccgga 296701 aacatttcaa aagcttcagc atattcattc catcaatcag aaagaaaaag ggctgtcagt 296761 cagccgcttt gttgcctttc tggacgggga aaagctgatt gcgaagcact caaatccctt 296821 gatgcaccgc catttaagaa aagcgttgat gacgctttta catacctttg cggacagtca 296881 tgaaaagggg ctgaatcatc ctgattttcg cagagtgctg cttgatgtct cgaagttttc 296941 cttaaaccat ctgaaccctt ggctggaaaa aaccgatata gagcgggaga tgccgaaggt 297001 tgtttggtat ggagatgcga cgaaaagcca gctctatttc ttatattatc tgatgctggt 297061 cggctgtgat gtactgctgt tccatccggc gggaacggat cagctggcgc ttgtcgaccc 297121 gaagcaggag ctcggtttta cggaaaagct cccggatgtt tcggagcttc agccgtttcc 297181 gaaagaaaaa ccagaccgga aatcaacagt ggcttaccgc tcaacaaagg aaattgaaca 297241 tgtgctgaat cacgaggaat ccatgctata taagccgtgg cagttcagag atcacacacc 297301 ggtgtccgtt acgctgaaaa cgacctatga tgaattgttt ttaatcacga aagaacgcgc 297361 ctttattcgg ccgaatttca aagctgataa acattccatt gagattccga atgtattcgc 297421 caaaattatg ggcgtgtcga aagacaataa ggaatattgg aacaggcttc atactctagc 297481 ggattatcag gaaacagaaa tggtcagaag ctttccattt acagaagaaa taaagtcgaa 297541 ctatcaattt cactacagcc acgcacttga tcaagaaggg aacattgatc cggacaagct 297601 gatggcaagc aatgtgtggc agtacaaaca gctgccggcg ggcgttcaga ctgccattgc 297661 caaaacgatt tcgagaatgt gcaggtaccc gcggcttaaa gccttgcatc aggaacaagt 297721 caaggatgtt caaatctatt tgtttaaaca aacaacaaac ctgcctgcta atctgctgaa 297781 attgattcaa atgttcgact atgcgcaaac cgttccgaaa ctcgttttat atcatacgga 297841 aatgagcggc ggactcacgc gttcggatgc tgccgccctg ctgttcctga atgaaatcgg 297901 aatcgatatc atcatttata atccgcccgg acaccaagat attgagcagt ttattgaaga 297961 ggatcagtat gatatccact ggctggatga catggtgttt cagcaggact acaaagagcc 298021 ttcgcttgtg aaaaggctct tcagaaccat tacccaaaaa taaggagaga agaaaagcat 298081 gacaacagaa aatcaaaatc cgcttgttct cgataaaaat gaagagattt cccagcaaaa 298141 agctgacgat atccgtcttc agctccgtca ggaaccagaa gtgaagcggc ttgctcaaca 298201 aattgacgtc aaaaaccaaa tggagctgct tgagtacggc aaggagccgg ccgttgaaat 298261 atccaagttc tctgaccgca tcttggggat gatgaaaaca acaagcgtga cagactccgg 298321 cacaatgctg actcagcttg ggaaaatcat ggaccgcttc gacaaaaatg attttgatga 298381 gccaaaggga ttaatggcga aaattttcaa acgcggcggc agcatgattg aaaaaatctt 298441 taaaaagtat cagacgcttg gcggagagat tgaaaaaatc cacgttgaga tttcaaaata 298501 caaagatgag atgacgaaga cgaactacac gctcgatgaa atgtatgaaa acaatatcaa 298561 atactatatg gagcttgaaa aatacgtcgt tgccgggcag atgaaactgg aagagatgca 298621 gtcgatcctt ccttcatatg aggaaaaagc ggcaagcggg aaccagctgg cgcaaatgca 298681 gctcgatacg ttgcgcaacg gcattcaggc gcttgaggaa cgggtgtatg atcttgacat 298741 ggcacggatg gtggcgcttc aaaccgcacc tcaaatccgt ctcctgcagc gaggaaatgc 298801 aaagctgatc gggaaaatca actccgcgtt tatcattacc attccgattt tcaaaaacgg 298861 cattattcag gctgttacgg taaagcggca aaagcttgtg gctgattcca tgagcgagct 298921 tgaccgccgg acaaacgaga tgctgaaacg aaatgctgaa aacatctcga gccaaagtgt 298981 tgaaattgcg agaatggccg gcagaccgag catagatatt gaaacgattg aatcgtcttg 299041 gaacacgatt gtcagcggca tgcaggaaac aaaacaaatc gaagaagaaa acaagcgcct 299101 ccgcgaagac ggcgcgagac gaattgccca gcttcaggat aatattaaaa aagcagcatt 299161 gcagcaataa taaaaacccc gcttgtggaa cataagcggg gtatttcaat tacatcattt 299221 agttaatgac aatgtgtaaa gacaggtgta aacttaaacg gtaatcattt tgcatatcag 299281 aggtgttggc aatgggaaaa caacagccta tatcccagcg taaactgctg ggcgtcgccg 299341 gtttggggtg gctgtttgat gcaatggatg tcggaatatt atcgtttatt atcgccgcgc 299401 tccatgtaga gtggaatctg tcgcccgaag aaatgaaatg gatcggaagc gtcaattcca 299461 tcggcatggc tgcgggtgcg tttttgtttg gtttgcttgc tgatcgaatc ggccgcaaaa 299521 aagtgttcat catcaccctt ttatgctttt ccatcggaag cggcatttcc gcttttgtga 299581 cgagcttatc ggcatttcta atccttcgtt tcgtgattgg tatgggactt ggcggcgagc 299641 ttccagtcgc ttcaacactc gtttcggaag cggttgtgcc tgaaaagcgg ggcagagtga 299701 ttgtgctttt ggaaagcttt tgggccgtgg gctggctcgc agcggccttg atttcttact 299761 ttgtgatacc aagcttcggc tggcaggctg cccttctgtt aactgcgctg actgcttttt 299821 atgcgctgta cctgcggacg agtctacctg attcgccgaa atatgaatcg ctttctgcca 299881 aaaagaggtc gatgtgggag aatgtaaaaa gcgtctgggc aagacagtat atacggccga 299941 cggtgatgct gtcgatcgtt tggttctgtg tggtgttttc ttattacggc atgttcctat 300001 ggctcccgag tgtcatgctg ctgaaaggct tcagcatgat tcaaagcttt gaatatgtcc 300061 tgctgatgac gcttgctcag ctacctggct atttctctgc cgcatggctg attgaaaaag 300121 cgggccggaa gtggatactc gtcgtttact tgattggcac agcaggaagc gcctatttct 300181 tcggaacggc ggattcctta agtcttctgc ttacggctgg agtgctgtta tcgtttttca 300241 atctcggtgc gtggggcgtg ctgtatgctt ataccccgga gcaatacccg actgcgattc 300301 gagcaacagg ttcaggaacg acagcagcgt ttggaagaat cggcggcatc ttcgggcctt 300361 tgctcgtcgg aaccctggca gcccgtcata tttcgttttc ggtcatcttt tcaatctttt 300421 gcattgcaat cttacttgcg gttgcttgta ttttgattat ggggaaagaa acgaaacaaa 300481 ctgagctaga ataggaaaag cacctcttaa aagaggtgct ttcagcgtgt cgacaaaccc 300541 tcgcattcgt tgtcaggact gcgcttcggt gctcaatgcg aagtggatca acggctaaat 300601 tctcaggcgt cctgcctaaa cgccgtcgtc atcacatcct gtgaatgtcc gctcctatgc 300661 tcgtccttcc tagacttcaa gggttttcaa tcacgctgaa aagattttgt caacaatctg 300721 aggcacctct tgaatgaggt gcttttttac aattgcgccc gggctgtgga ttggcgtttc 300781 ccggttttac tgattgtctg gtagagcgtc atagaaagta tgaacagaat ggcagtaaat 300841 cctgtgacag ctccgaaatg ctgtgtgctt tgatataaaa aacctgcaat acttgtaccg 300901 acagtggttc cggcatacat agcggcattg gaaagggaag cgatggttcc tcgcgcattt 300961 ggtgcaatgg attgaaagac acccatcatt aacggaaaga tgatgccagc tgtaaagaac 301021 gtgagaaaaa agccggcttc tactaaaaac aagtttggaa agaacggaag agcgaaatag 301081 agagcgccca ttagcagcat cccgctgatc agtgttttaa acatgcccag cttttctgaa 301141 acccggctgc cgataaggct cccgagcata tttcccagtc cgagtacaag catagctgcg 301201 ccaatttgtg acacggttaa atgataatcc gcggaaagcc aagtacccag aaagctgaac 301261 gatgcgaagt ttccggtttg aaacagaaaa taggcaagca gaatgaccga tgttttcggc 301321 aatgaaaaaa gctcccgata ggggttgaca attgatgggc gcgccaatgg ttcagaaggc 301381 cggatgccag gcatgaccgc cgccaggatc aatagaagaa taagcgagca cgctgacaaa 301441 acgaaaaatg gcgtatgcca tgtaaaggaa gcgagaaacc ctccaatagg aagtccgagc 301501 atttgtgaag cggccaaacc tgctgtcgca atccccatgc cttttatgat ctgagaaggc 301561 tggacaatga ctgggatgga cgcccaaatt tgaggcgtca caaacgcagc gctaacgcct 301621 gcggcaaaac ggaacaggca catggcggca aaagagggag cgatgccgca taaaaatgtg 301681 gatacgataa agcctgcaag tccccacagc atgactgttt tcctgttcag ccggtctgag 301741 attgggcctg caatgaaagc gaagagtgca taaccgagtg cataagcact gaccatccag 301801 cctgacaaat cagtagagac atgaaactga tcctgtaaaa gggggagaag cggcgaaagc 301861 aaaaaggtat ccgtgccaat gacaaacatg acactgaaga aaagccaaat gcgattcaaa 301921 ttttatcact cctattgttt tataacttta aaactatgaa acagatatgt atagagaaaa 301981 ccctttgtta gagggtttcc aaaaagccag gcaggtatgt ttgaaatgtg tcttcacgca 302041 gactgacgta ttttgtccgc gaatctttcc gggttgccgt caatcccgct tcacgcagcg 302101 ttttaaaatg ataagatgcc gtggttttga caatattgca cttttcacct acttcaccgc 302161 agctgagttc ttttccgctg acataaagcg tacgaataat ggcaagcctt gattcatcag 302221 acagtgcttt aaaaatttgc gctctgattt gatcatctga ttgtttcata gtcatgaaac 302281 tataatacat aatgggtgtt gaaaaagcaa cttatttttc cagtaaagga gcaggaagtc 302341 ataagaggaa ggaggaattc aattccaata aaagcgtttt caactaaagg taggagaaaa 302401 atcacccgta aaatacaatc atataggagg attacagagc atttagaagc ataaataaga 302461 tcatgtggtc acatggatgt ttataaagaa atggtacaga ataaaagaga atatgctgtt 302521 tgtgtgggaa gttacataaa tgttacggta ataaagattg cttaatatgg agggaaaata 302581 tgagtgtaga tgagaaacca attaagataa aagtcgagaa agtctctaag atttttggga 302641 aacaaacaaa gaaggcagtt caaatgcttg ccaacggaaa gacaaaaaaa gagatcctga 302701 aagcaaccgg atcaaccgtt ggggttaatc aggcagattt tgaagtatat gatggtgaga 302761 tatttgtcat catgggtcta tcagggagcg gtaaatcaac tttagtacgg atgttaaacc 302821 ggcttattga accgactgcc ggaaatattt acattgatgg tgacatgata acaaatatgt 302881 caaaagacca gctccgggaa gtccgccgga aaaaaatcag catggtcttc caaaagttcg 302941 ctctgtttcc gcacagaacg atacttgaaa acacagaata cggactggag cttcaaggtg 303001 tagacaaaca agagcggcag caaaaagcgc ttgagtctct taagctcgtt ggactggaag 303061 gatttgaaca ccaatatccc gaccagcttt ccggcgggat gcagcagcgt gtcggccttg 303121 cccgcgcgtt gacgaatgac ccggacatcc ttctgatgga cgaagcgttc agtgcgctcg 303181 atccactgat tcgtaaagat atgcaggatg agcttcttga tcttcacgat aatgtcggaa 303241 aaacaattat ctttattacg catgacttgg acgaagcgtt gcggatcggc gacagaattg 303301 tcctaatgaa ggacggcaac atcgttcaaa tcggcacgcc tgaagaaatc ctgatgaatc 303361 catctaacga atatgttgag aaattcgtcg aagatgttga tttgtctaaa gtcctcacag 303421 caggccacat tatgaaacgc gctgaaacag tgcggattga taaagggcct cgcgtagcat 303481 tgacactgat gaaaaacctt ggaatttctt caatttatgc agtggataaa caaaagaaat 303541 tattaggtgt tatctatgcg tctgatgcga aaaaagcggc tgagtctgat ttgtcacttc 303601 aagacatctt gaatacagaa tttacgactg taccagagaa tacgtatctg actgagattt 303661 ttgacgttgt gtccgatgcg aatattccaa ttgcggttgt ggatgagaag caaagaatga 303721 aaggaattgt cgtaagaggc gcgctgattg gcgcacttgc cggcaataac gagtatatca 303781 atgctgaagg cactaacgaa caaacacaag atccttctgc acaggaggtg aaataagatg 303841 gatagactgc ctagaatacc tttagcagat attattgacc gttttgttga ctggattacg 303901 atgacgtttg gcggattctt cgacggaatc gctaacggat tggccgcttt tgtaaatgga 303961 attgtcaccg gtcttggatt tattccatct attttgttaa cgattatttt cgccgcactt 304021 gcgtggtgga tcagtacaag gggaattgcg ttatttacgt tgattggatt cctcctgatc 304081 gattatttag gatattggga cccaatgctg caaacattgg cgcttgtttt gacatctgtg 304141 attatttcga ttgtggtcgg ggttccgatc ggaatttggg cgtctcagaa agaaacggtt 304201 cgccgtattg taacgccaat tcttgattta atgcagacaa tgcctgcttt cgtatatcta 304261 ttgccggcga ttttcttctt taacatcggt gttgtgccgg gtgttgttgc atctgttatc 304321 ttcgcgatgc cgccgacaat ccgcatgact gttctcggta ttaaacaagt gccggcggat 304381 ttgattgaag cgactgaggc attcggttct acaacagctc agcgtttgtt taaagttcag 304441 ctcccgcttg cgacaaaaac gattttggcc gggatcaacc agagcatcat gcttgcgtta 304501 tcaatggttg ttatcgccgc aatggtcggt gcaccgggac ttggttctga agtatacagt 304561 gccgttacac agctgaaaac cggggtcgga gtagaggccg gtatcgccat cgttatcgtt 304621 gccattaccc tggaccgtat tactcaaaat attaaagtga agaagaaaag cagggggaat 304681 gcctgatgct taaaaaaatc ataggcatcg gcgtttccgc catgctggcg ctctcacttg 304741 cggcttgcgg ttcagaaaac gatgaaaatg catccgcagc agaacaagtg aataagacca 304801 tcatcgggat tgaccccggt tcagggatta tgtccctgac tgacaaagcg atgaaggatt 304861 atgacctgaa tgactggaca ttgatttcag cgtcaagtgc tgcgatgacc gctacgctta 304921 aaaagtcata cgaccgtaag aaaccgatta tcattacagg atggacaccg cactggatgt 304981 tctccagata taagctgaaa tatctcgatg atccgaaaca atcttatggc agcgcagagg 305041 aaatccatac gatcacacgc aaaggcttca gcaaagagca gccgaatgcc gcaaagcttc 305101 tgagccagtt taaatggacg caggacgaaa tgggcgaaat catgatcaag gtggaagaag 305161 gcgagaaacc tgccaaagtt gctgctgagt acgtcaataa acacaaggat cagattgccg 305221 aatggacaaa aggcgttcaa aaggtgaagg gagacaaaat caaccttgcc tatgtggcgt 305281 gggacagtga gattgcaagt acaaacgtca taggcaaagt cttagaagac ttgggctatg 305341 aggtaacact tactcaggta gaggctgggc cgatgtggac tgcaattgcg acgggaagtg 305401 cggatgcatc cctttccgca tggctgccga atacccataa agcatacgcc gctaaatata 305461 aaggcaaata tgatgatatt ggcaccagta tgactggtgt gaagatgggg cttgttgttc 305521 ctcaatatat gaaaaatgtc aactcaattg aagatttgaa gaagtaatca aaaaagcagc 305581 ctgtgtcagg ctgctttttt tgcgttaaga agcgttagcg gcagcaagtg attccgcctt 305641 ctgaaatgtt ttgagcacgg cgttcgccaa aatatgaatg ccggtaaaca tcgcatttct 305701 gtcaaaggtc atgtgcggat gatggagccc cggctggagc ccgcagccta gtccgagcat 305761 cgttgttttc agattcggca ccttcacggc gtaaaaatgg aaatcctcgc cgccggtggt 305821 gacaagcggg tcatcaagcc gctcagcccc gatgatttcc gtaatggctt ctgccatgat 305881 cgcttcagct tctttatttt gtgttgccgc aggaaggctg tgttctttgt gcagctcgat 305941 ctttgcgcca aatgcagcgg cggccgcttc acaggctctt tctgtttcgg cgattaatgc 306001 ctccatggct tcattggtct gtgcgcgcaa atcaaggctg aacgatgctt ttcctggaat 306061 gatgttagag ctttcaccgc cggcttgcag ttttgtcatt ttgacggtat gcgggatttg 306121 cgggtcaata tgaatgagtc cgagcttgtg tacaagaaat gccgcaattt caatgctgtt 306181 tttcccgagg tgcggacggg cgccatgagc ctcttccccg atgatcgttc cctcaatgtg 306241 ctggcttgat ccgtgcagaa tagaaggagc gcagcggccg ttctgtgttt cctggatcgg 306301 acggacgtga acgccataca aatagtcgat atcatcaagc acgccttctt ctatcatttt 306361 caaggcgccg ccgccttttt cttctgccgg ctgaaagata aaacggattg tgcccttcgg 306421 aagctcaggt tgttttttta gcagcattaa cgtgcccaat gccattgtca tatgtgaatc 306481 gtgtccgcag gaatggttgg cgcgaaatgt gccgttaacc tcctgccaca gcgcgtcaat 306541 atcagcgcgt accgctacaa caggtgagcc tgagccgatt tcgccgacaa ccccggtgca 306601 gtctgaaaac gtgcgcgtcc ggcaccctaa atcctcaagc ttttgtttca aaaatgaagt 306661 tgtctcatat tccttccagc tgacttcagg gttcgcgtgc agatgctcga agatgtccat 306721 aatggtttgt ttcatttctt ctgaaagctt ttgcatggta agaaatacct ccttctatca 306781 gaatgaattt ttaccttctt tactttattt atattgaaac aggaagatag gctgtatata 306841 atatagcaca tattgctact attcagaata attaatattt tcaaacagag gggatggatc 306901 gaaatatgag tatgccagca gccgaaacac agcctaagaa aaaacgtatg acatttaaaa 306961 tgcctgacgc ctatgtcctc ttatttatga ttgctttcat ttgcgcaatc gcttcatata 307021 ttgtgccggc aggtgaattt gaccgcgtga caaaggggga tgtcacgacc gctgttccgg 307081 gaagctatca ttcaattgaa cagtctccgg tcagattgat cagctttttt acttctctac 307141 aggatggaat ggttggatca gcacccatca tctttctgat tttattcaca ggcggcacca 307201 ttgctattct agaaaaaacg ggtgccatca atggcctgat ttacaatgtc atcagcaaat 307261 tccgcacaaa gcaattatta tttatttgta ttgtcggcgc attgttctcc attctcggaa 307321 caaccgggat tgtcgtgaat tcagttatcg gttttatccc catcggcctc attgtggcac 307381 gatccttaaa atgggacgca gtcgcgggag ccgctgttat atacatcggc tgctacgctg 307441 gatttaactc caccatatta tcaccgtcac cgctcggttt atcacaatca atcgcggagc 307501 tccctctttt ctcaggaatc ggcctgcgag ttgtgatata catatgcttt ttgctgtctt 307561 ctattattta tatctatttg tatacgagaa aattaaaaaa atcaaaagat gccagtgtgt 307621 taggaacaga ttggttccct gcggcaggaa tgggcgaagc cggtaaagaa gaagatcagt 307681 cagtgccgtt taccgttcgc cataagctga ttttggctgt ggcgggactc tcacttgtcg 307741 gatttttata cggcgctttg aagcttggct ggtcagattc ccaaatggct gcgacattta 307801 tttttatttc tgtccttgcc ggtttaatag gcgggcttgc ggcgaacgat attgccaaaa 307861 ccttcattac gggctgccaa agtcttgtat acggggcgct gattgtcggg atggcacgaa 307921 gcatttccgt tatccttgaa aatggaaagc ttctcgatac tgtcgtcaat gctttggctt 307981 cacttttgga tggattcagc ccgattgctg gggcaatcgg catgtatatc gccagtgcgc 308041 tgcttcattt tctcatctct tcaggttctg gcgaagccgt tgtatttatt ccaatcctgg 308101 cgccgctcgc tgatttgatg ggaatcacga gacaggttgc ggttgaagcg gttatgcttg 308161 gagaaggggt cgtcaactgt gtgaacccga catccggcgt tctcatggcg gtgcttgccg 308221 ccagcggtat tccgtatgtc aagtggctgc ggtttatggt gccgcttgct ctgatttggt 308281 tcttgatcgg gcttgtcttt atcgtgatcg gagtcatgat caattggggg ccgttttaac 308341 gattgctgcc cgccggcttg tacggcgggc ttttgagtta ttcattgcag aagcgcaggc 308401 tgttattgta acatgtaagc cataagccat tcgtaaaagt gcgggaggaa ggtcatgaat 308461 aatctgcgta atagactttc aggcgtgaat gggaaaaata agagagtaaa agaaaaagaa 308521 caaaaaatct ggtcggagat tgggatgata gcgggagcat ttgcgctgct tgatgtgatc 308581 atccgcggca ttatgtttga atttccgttt aaagaatggg ctgcaagcct tgtgtttttg 308641 ttcatcatta tcttatatta ctgcatcagg gctgcggcat ccggaatgct catgccgaga 308701 atagacacca aagaagaact gcaaaaacgg gtgaagcagc agcgaataga atcaattgcg 308761 gtcgcctttg cggtagtggt gcttacgatg tacgacaggg ggattcccca tacattcttc 308821 gcttggctga aaatgattct tctttttatc gtctgcggcg gcgttctgtt tctgcttcgg 308881 tatgtgattg tgaagctggc ttacagaaga gcggtaaaag aagaaataaa aaagaaatca 308941 tcttttttgt ttggaaagcg agggaagcgt tcacagtttc gggcagcttt ttttatagga 309001 acattgattt gtattcactc tgccaagttg ttttgataga gtgattgtga taattttaaa 309061 tgtaagcgtt aacaaaattc tccagtcttc acatcggttt gaaaggagga agcggaagaa 309121 tgaagtaaga gggatttttg actccgaagt aagtcttcaa aaaatcaaat aaggagtgtc 309181 aagaatgttt gcaaaacgat tcaaaacctc tttactgccg ttattcgctg gatttttatt 309241 gctgtttcat ttggttctgg caggaccggc ggctgcgagt gctgaaacgg cgaacaaatc 309301 gaatgagctt acagcaccgt cgatcaaaag cggaaccatt cttcatgcat ggaattggtc 309361 gttcaatacg ttaaaacaca atatgaagga tattcatgat gcaggatata cagccattca 309421 gacatctccg attaaccaag taaaggaagg gaatcaagga gataaaagca tgtcgaactg 309481 gtactggctg tatcagccga catcgtatca aattggcaac cgttacttag gtactgaaca 309541 agaatttaaa gaaatgtgtg cagccgctga agaatatggc ataaaggtca ttgttgacgc 309601 ggtcatcaat cataccacca gtgattatgc cgcgatttcc aatgaggtta agagtattcc 309661 aaactggaca catggaaaca cacaaattaa aaactggtct gatcgatggg atgtcacgca 309721 gaattcattg ctcgggctgt atgactggaa tacacaaaat acacaagtac agtcctatct 309781 gaaacggttc ttagacaggg cattgaatga cggggcagac ggttttcgat ttgatgccgc 309841 caaacatata gagcttccag atgatggcag ttacggcagt caattttggc cgaatatcac 309901 aaatacatct gcagagttcc aatacggaga aatcctgcag gatagtgcct ccagagatgc 309961 tgcatatgcg aattatatgg atgtgacagc gtctaactat gggcattcca taaggtccgc 310021 tttaaagaat cgtaatctgg gcgtgtcgaa tatctcccac tatgcatctg atgtgtctgc 310081 ggacaagcta gtgacatggg tagagtcgca tgatacgtat gccaatgatg atgaagagtc 310141 gacatggatg agcgatgatg atatccgttt aggctgggcg gtgatagctt ctcgttcagg 310201 cagtacgcct cttttctttt ccagacctga gggaggcgga aatggtgtga ggttcccggg 310261 gaaaagccaa ataggcgatc gcgggagtgc tttatttgaa gatcaggcta tcactgcggt 310321 caatagattt cacaatgtga tggctggaca gcctgaggaa ctctcgaacc cgaatggaaa 310381 caaccagata tttatgaatc agcgcggctc acatggcgtt gtgctggcaa atgcaggttc 310441 atcctctgtc tctatcaata cggcaacaaa attgcctgat ggcaggtatg acaataaagc 310501 tggagcgggt tcatttcaag tgaacgatgg taaactgaca ggcacgatca atgccaggtc 310561 tgtagctgtg ctttatcctg atgatattgc aaaagcgcct catgttttcc ttgagaatta 310621 caaaacaggt gtaacacatt ctttcaatga tcaactgacg attaccttgc gtgcagatgc 310681 gaatacaaca aaagccgttt atcaaatcaa taatggacca gagacggcgt ttaaggatgg 310741 agatcaattc acaatcggaa aaggagatcc atttggcaaa acatacacca tcatgttaaa 310801 aggaacgaac agtgatggtg taacgaggac cgagaaatac agttttgtta aaagagatcc 310861 agcgtcggcc aaaaccatcg gctatcaaaa tccgaatcat tggagccagg taaatgctta 310921 tatctataaa catgatggga gccgagtaat tgaattgacc ggatcttggc ctggaaaacc 310981 aatgactaaa aatgcagacg gaatttacac gctgacgctg cctgcggaca cggatacaac 311041 caacgcaaaa gtgattttta ataatggcag cgcccaagtg cccggtcaga atcagcctgg 311101 ctttgattac gtgctaaatg gtttatataa tgactcgggc ttaagcggtt ctcttcccca 311161 ttgagggcaa ggctagacgg gacttaccga aagaaaccat caatgatggt ttcttttttg 311221 ttcataaatc agacaaaact tttctcttgc aaaagtttgt gaagtgttgc acaatataaa 311281 tgtgaaatac ttcacaaaca aaaagacatc aaagagaaac ataccctgga aggatgatta 311341 atgatgaaca aacatgtaaa taaagtagct ttaatcggag cgggttttgt tggaagcagt 311401 tatgcatttg cgttaattaa ccaaggaatc acagatgagc ttgtggtcat tgatgtaaat 311461 aaagaaaaag caatgggcga tgtgatggat ttaaaccacg gaaaggcgtt tgcgccacaa 311521 ccggtcaaaa catcttacgg aacatatgaa gactgcaagg atgctgatat tgtctgcatt 311581 tgcgccggag caaaccaaaa acctggtgag acacgccttg aattagtaga aaagaacttg 311641 aagattttca aaggcatcgt tagtgaagtc atggcgagcg gatttgacgg cattttctta 311701 gtcgcgacaa atccggttga tatcctgact tacgcaacat ggaaattcag cggcctgcca 311761 aaagagcggg tgattggaag cggcacaaca cttgattctg cgagattccg tttcatgctg 311821 agcgaatact ttggcgcagc gcctcaaaac gtacacgcgc atattatcgg agagcacggc 311881 gacacagagc ttcctgtttg gagccacgcg aatgtcggcg gtgtgccggt cagtgaactc 311941 gttgagaaaa acgatgcgta caaacaagag gagctggacc aaattgtaga tgatgtgaaa 312001 aacgcagctt accatatcat tgagaaaaaa ggcgcgactt attatggggt tgcgatgagt 312061 cttgctcgca ttacaaaagc cattcttcat aatgaaaaca gcatattaac tgtcagcaca 312121 tatttggacg ggcaatacgg tgcagatgac gtgtacatcg gtgtgccggc tgtcgtgaat 312181 cgcggaggga tcgcaggtat cactgagctg aacttaaatg agaaagaaaa agaacagttc 312241 cttcacagcg ccggcgtcct taaaaacatt ttaaaacctc attttgcaga acaaaaagtc 312301 aactaaccgc aactttagag taaagggctg attgtcaatg tgggagcagt tgtatgatcc 312361 gtttggaaac gagtatgtga gcgcacttgt ggcgctcact ccgattctct tttttctttt 312421 ggctttaact gttttgaaaa tgaaaggcat tcttgcggca tttcttaccc tagccgtcag 312481 tttcttcgtc tccgtttggg catttcatat gccggttgaa aaagcgattt cttctgtttt 312541 gttaggaatc gggagcgggc tgtggcccat tggctacatc gtcctgatgg cggtgtggct 312601 gtataaaatc gccgtgaaaa ccgggaaatt taccattatt cggtccagca ttgccggcat 312661 ttcgcctgac caacgattac agctattatt aattggtttt tgttttaacg cgtttttaga 312721 aggcgcggcc ggttttggtg ttccgattgc gattagtgcg gcgctgctcg tcgaacttgg 312781 ttttaaaccg ttaaaagcgg cggcgctctg cttgattgca aacgctgcct ccggagcctt 312841 tggggcgatt gggattcctg tcatcacagg ggcgcagatt ggtgatttgt ctgctcttga 312901 gctgtctcgg acattaatgt ggacactgcc gatgatctca tttttaatac cattcctgct 312961 tgtattctta ttagaccgaa tgaaaggaat caaacagaca tggcccgctc ttctggttgt 313021 gagcggtggg tatacagcgg ttcagacact gacaatggcg gtgctcgggc cggaattagc 313081 aaacattttg gcggccttat tcagcatggg cgggcttgcc ctcttcctcc gcaaatggca 313141 gccgaaagag atttaccgcg aggaaggggc cggcgatgct ggtgagaaaa aggcataccg 313201 tgccgctgac attgcgaaag cgtggtctcc tttctacatt ttaactgcgg cgatcaccat 313261 ctggagcctt cctgccttca aagcgctttt ccaagaaggc gggctgttat atcaatcaac 313321 gctcctgttc aaaatgcctt ttctgcatca gcaaattatg aaaatgccgc cgattgcgcc 313381 atctgccatg ccgttagatg cagtctttaa agttgatctg ctgtcagcga ctggtacagc 313441 gattttagcg gcggtcatcg tgacagggct gttcagcaaa aagttctcct ctcgggatgc 313501 ctttgcttcc ttgaaggaga cgggaaaaga gctgtgggtg ccgattatga cgatctgctt 313561 cgtgatgggg tttgccaatc tggccaactt cgcagggctc agctcttcaa ttgggttagc 313621 attggcgaaa acaggagacc tgttcccgtt tgtcagtcct gttctcggct ggattggcgt 313681 gttcatcacc ggttctgttg tcagcaataa tgctttgttc ggccatttgc aggttgtcac 313741 gggagcgcag atcggtgcgg gttcagattt gctgttagcc gcaaatacgg cgggcggtgt 313801 catggcgaaa cttgtttctc ctcaatctat cgccatcgct gccgcagcgg tcggccaaac 313861 aggcaaggaa tctaaactgt ttaaaaggac agtggcgtac agcctgattc tgttattgat 313921 catttgtata tggacgttta ttcttgcaag attaggagtg taatagaaaa aagcagtaca 313981 tgcccagcat gtactgcttt ttttatgtta atttgctttc tttgtcattt cggctgttgt 314041 tttcactctg gcttttccca taaataaaat ggtaaccgcc gcgaggacaa ttggaatcaa 314101 agcgagcaaa aagacatacg tgatacttga tgacatcgcg tcaataatgc gattcaggat 314161 cgcatcagga atctgggaac gtgttcccgc ttggaatatc tcctgcgggt cgccaatatt 314221 ttgcgcagcg cctgatcccg ctgagccttt cataccgctg aaggcgtcat tcagcttgtt 314281 tgtgaatacg tttgtttgca ccgttccgaa aatggtgaca cctaaggtca tgccaaatga 314341 tcgcaaaaat gaatttgtag agtttgccgt tccccgaaag cgaggttcaa gatcattcat 314401 cgatgccgcc ggcagcaggg agaagttaaa gcctacacca aagcctgaaa tcatcataaa 314461 gactgtcagc catacccgtg ctgtgtcagg cgtcatattg gaaagaagca gcatgccgat 314521 aaagaaagct ataacagata tcagcatcaa attgcggaag cttgccttcg tttggaagat 314581 cccgccgatc atgcttccga tgactgatcc aatcatcatc ggcgtcagaa tgaagcccgc 314641 gcttgtcgcc gagctgccgt agaccgcctg aacgaaaatc ggaataaata ccgctaaaat 314701 aataaatgtt ccgccataca ggaaagcgag aatctgtgct gtggcaaaca agcggttctt 314761 aaacatccag aaagaaataa tcggctcttc tgcttttctc tccacaataa aaaaggcaat 314821 gaagaaaacg gcgaatacaa taaacagccc gatgatctga atggagttcc aatcgtatgt 314881 tttgccgcca agctcaaggg cgaacatcag gcatacaatg gatacgacta aggtaatcgc 314941 gccgccccag tctattttct gctttctgtg ctccagagat tctttgtagt agcgaataat 315001 gaaaaacaat gacaatgcgc cgatcggcac attgatgtaa aacacccagt gccagctgat 315061 cgaatctgta atgatcgcgc ctaagagcgg accaagaaca ctggataatc caaatacagc 315121 accgaacatg ccggacattt ttccgcgttt ttccggcgga aacaaatcaa agataatggt 315181 aaaggcaatc ggcaggagcg cgccgcctcc gatcccttga atggcccgga agatgatcag 315241 ctgattcatc gtctgggcaa tcccgcataa agcagaaccg attaagaaaa aaataagtcc 315301 aaacaggaaa aaacgttttc ggccgtacat atcggaaagc ttgccgtaaa tcggcatgcc 315361 agccataacc gccaccatat aggatgccgt cacccaggca aatttatcga agcttccaag 315421 atcggctacg atattgccca tcgcggtggc aacaatcgta ttgtccattg cagacatcaa 315481 gatgcccagc aggagaccga ggaccacaaa tttggtggaa gcctgttttg ctgttgttgt 315541 gtccatttgt tctacctcct cttacttttc tatgtaagtt ctgatatcat gataatagtt 315601 tgattgttga atatctcgat tatcaagata aactcgattt tatagggagg actgtcagtt 315661 gtcaacaaga aattccagaa gtgagttgga aaagactgct gttcagcttt ttcgaaaact 315721 gggcacaaga acggttctgt ttcatcaggc agccgctcaa gctctcggtc tgtttcccac 315781 cgatttgaaa tcagctgaca ttttaaatga agcagggccg atgacggccg gagagctggg 315841 gaaaaaaacc ggcctcagca cgggttccgt cacggcgctt gttgaccggc tggaaaaagc 315901 ggggtatgtg gctcgtgaaa aggacccgaa cgatcgcagg agagtcgtaa tcgtcccttt 315961 gactgcttcg aaaaaacata taaaggattt gttccgtcct ctgtctgagt caacgatgga 316021 tttgtgccgc gaatatacgg aagaggagct ggaactcatt ttcagttttg taggcaaagc 316081 tgccgatatt atggaggaag agcttgaacg tctgaaacag taagtgaatt tgtgcatagc 316141 ttggcccgtt cccgaataaa ttgtacaagt tacataagag aagggagtac gggccggtga 316201 acattttttt gagctatatt gtgctgggac tgtccttgtc tgcgcctgtg gggccagtga 316261 atgcggcgca aatagacaaa ggaattaaaa acggtttttg gcatgcatgg attttcggtt 316321 taggcgccat gacagcggat gggctgtaca tgctttttat ctatttcggg ctgtcgcagt 316381 tcttgaccgc tccatttgtg aaaacgtttt tgtggctgtt cggctttttt gtcctgacct 316441 ataccggaat tgaaacgctg aaaaacgtca gagaaccgat ggatgtgcga agctcgcggg 316501 ggaaaccgtc atacaggaaa acattcgcat cgggttttct catttcattg tcaaacccat 316561 tgagcatcct tttttggctt ggaatttacg gaagcattct tgcgaaaaca gcagaggcct 316621 acaatatgaa tcagcttcta atctatagct ccggcatcat gatcggcatt ttaatctggg 316681 atttctgcat ggctatcaca gccagtacgt tcagaaacct gcttcatgaa aagctattga 316741 gaggattgac cggaatcgcc ggtgtatccc tccttgtgtt tggcttttac tttggttatc 316801 agggcatcaa acagttattg ggctgattca tgaaggacag tcacctgccg cttccagttt 316861 taatatagta tccagatgat actggaggtg gatcaatggt gaatgggatt tacaccaaaa 316921 gttttctgga acgtattcag gaagagcttc ctgaatggca aagaatcgct tttgagctgc 316981 tggcagaaac tctgggggac gacgcggata catttccgtg cattcccgga cgccaggcgt 317041 ttctgactga tcagcttcgg attgcttttg ccggagatcc gcgggaaaac cgcacagcgg 317101 aggaactggc tccgttgctt gcggagtacg gcaagatatc gcgggacacg ggaaaatacg 317161 catccctcgt tgtgttgttt gatacaccgg aagatttggc ggagcattat tcgattgaag 317221 cgtatgaaga gctgttttgg cgctttttaa atagactgag tcatcaagac gaaaaagaat 317281 ggccggaaga cattccggcc gatcctgagc attataaatg ggagttttgt tttgacggcg 317341 agccgtattt cattctgtgc gctacaccgg ggcacgaggc aagaagaagc cggagctttc 317401 ctttttttat ggtcacgttt cagccaaggt gggtgtttga tgacctaaat ggatcaactg 317461 catttggccg taacatgagc aggctgatcc gatctcgttt agaggcctat gatcaggctc 317521 cgattcaccc gcaattaggc tggtacggag gaaaagataa tcgtgaatgg aagcagtatt 317581 tcctccgtga tgacgaaaaa caggtatcga agtgcccgtt ttcttattta aagaacatgt 317641 tcaacaaaat gaaataaatc aaggactggc agggcgatct ttatgaccct gctttttttg 317701 atagatcatg gtaacgatgg cgataatcac gagaaaacct atgctgacga aaaaaccggg 317761 ccggcttgat ttttcaaaca atgtaccgga cacagctgca gcaatcagaa ccatcgctaa 317821 ataaatttgc gtttttccca tgccctcggg atcagtcagc tttttgctgg agaacaggat 317881 aaacagccaa gtgtataaaa gcataagccc cgcagctgtt gtcatatgct cataaatgtt 317941 tttaggcagc actaacgaca aaataatgga gaggacaagc cccgcaaacg tcagcccaag 318001 tgccggccag catatttttt tgccttcctt tagagtaaag catttcggcg cgtcgccgtc 318061 atcagccatt gtacaaagca atgtcgtaac cgcaaatagc gaagcgacaa gggtcgagaa 318121 ccctgcgatg atgaaaatcc cgttaaatat atcaaggatg atctcaaggt tatatccttt 318181 taatgacgta atgaacggac tgtcctgttc agtaaacgtg tgtaacggaa ccaaaagcag 318241 agcaagcccg attgaaatga tataaataat cgccagcgtc gccagcatca gtttccctga 318301 tttagacgct tcctcaggtt tttttaagtg aaccgccatc agccccatga cctcaattcc 318361 gccaaaagcg taaaacgcgt agattaaacc tgtccacagc cccatggcgc cgtatgggaa 318421 aaactcactc gtcttatttg gaacatgtat gccatgattt ccgccggaca ggataccgca 318481 taaagccagg atggcaatga caataaacat aaaaatagca gctgttttaa tgactgccag 318541 cacgttttct gttttttcaa agacggacag gccggtgaaa ataataagga gcccaagtac 318601 tgcgtagatt gaggcaaaca cccatagcgg cacttgagga aaccaatgct tcgtaaagag 318661 cgaaatggct gtcagctggc ttccggtaat cagcatttct gatgtccagt acacccagcc 318721 gttgctgaag cctgcccatt tgccgaatgc ttttcgggca tacgcacaaa acgagccctt 318781 ttccggctgc ttcgccgata gcttggcgag ctgttcaaag acaaaatacg taccgatccc 318841 tgcgatcaga aatgaaagga gaacggaaaa accgcttttt acaattgcga tgctggaacc 318901 gagaaagaag cctgttccaa tcgtgcagcc gactccgatc agtgacagct gccaccaagc 318961 cagattccct tttggctggt ctttttttgt ttggctcatt atttattcaa ccccttttat 319021 ctaaggttag attgtgatct gtccaaagct tatatacatc ggatttttgc ctctttttac 319081 atggagaagg aagcagacgc tcatactaat gaaaaaagga gcaaaccaat gacacagcaa 319141 tatattgtgg agccgaaaaa agggcttggg ctgaagctga aaaaggggca gattttaaag 319201 gtggttgatg tagaagggca gcaggtggct gattttgtcg cataccatgc caaggatttt 319261 tatgaacacc ttgatcaggg agcgacgata gacgccaatc actccattca tgtgaaggtc 319321 aacgaccatc tctactccaa cctgtataag ccgatgttaa ccctgattga agatacggtc 319381 ggcaagcatg atctgctgtt gcccgcctgc cgtcctgata tgaacaggct cttatatggg 319441 aagcaaaagg atgagtttca ggatacgtgc tatgacaata tgaaccgtgc gcttgagcag 319501 tttggcgtac cgaagcccca catgcattac ccatttgcga tttttatgaa tactgtcctt 319561 gatgagaaag ggaatctgtc tgtggaaacg ccgctttcga atgccggaga ttatgtaagg 319621 ctcagggcgg agatggattt aattgtcgcg ttttcttcct gcccgattga aaaagggaaa 319681 tgcaatggcg acagtgtgac atccatacgg gttgaagtca gctgatctct cttgttcaca 319741 gtgaatgaag acctgtgcta tatttaatag ggatacataa cagtcatgat tcattttcat 319801 tgatttaggg aaatgatcag taataaggga aaatgtacag gaggaatgat tgggatgagc 319861 atgcaggaaa agattatgcg tgagttacat gtgaagccct caattgatcc aaagcaagaa 319921 attgaggacc gagtcaattt tttaaaacaa tatgtaaaga aaaccggtgc taaaggcttt 319981 gtattgggaa tcagcggggg ccaggattca acacttgcgg gaagactcgc tcagcttgcg 320041 gtggagagca ttcgcgagga gggcggagac gctcaattta tcgcggtccg tcttccgcat 320101 ggcacacagc aggatgaaga cgatgcccag cttgctttga agtttattaa gccggataaa 320161 tcatggaagt ttgatattaa atcgacagtc agcgcttttt ctgatcagta tcagcaggaa 320221 acaggcgatc agctgacgga ctttaataaa ggaaacgtaa aagcaagaac aagaatgatc 320281 gcgcaatacg cgatcggcgg ccaggaaggt cttcttgtgt taggaacaga ccatgctgct 320341 gaagcagtga ctggtttctt tacgaagtac ggtgacggcg gagcagacct cctgccgctg 320401 acaggcttga cgaagcgcca gggaagaacc ttgctgaaag agctgggtgc accggaacgc 320461 ttatacttaa aagaaccgac tgccgatctg ctcgacgaaa aaccgcagca gtcggatgaa 320521 acagagcttg gcatttccta cgacgagatt gacgattatc tcgaaggaaa agaagtatca 320581 gcgaaagtat cagaagcgct ggaaaaacgc tacagcatga ctgaacataa acgccaggtt 320641 ccggcgtcta tgtttgatga ctggtggaaa taagttgaag aaagcccgct ctcggagcgg 320701 gcttttgtcg tgtacagaag ctttatttga tgcggatatg attcagcttt accattaatc 320761 tgtcggcgaa ccttcggagg ctgcctcttg tatcaggatc taatgggagt tcggctctcg 320821 cggcaatgtt ctctgccaca tcctgaatcg acaggttgtc tgtttgaatg tggtcctcaa 320881 aaatgggtga tgataatcct tcaacacagc ggtcaatttg tttggcggcc catgagtttt 320941 ttccttctgc tctggtgcgc agccttttta acaaggtttc ctttgaagcc attagtgtaa 321001 agtggtgaac gatcctgcct tcctgtctga gcctgccgat gatctcattg aagtattcag 321061 ggtgtacaat cgtcataggc acaataagga tgccgcggta tgtatctgtc agagaagcta 321121 gcaaactgta attgaacgcc cgccataaag gatagctttg aaaatcgtcc tttgcgatct 321181 cctgcggcac catggagcgc agcgcaaaac ccattttctc gggatcatac acgtaagatg 321241 ggttcagcct tctgtgcagt tcgaaggctg tttgtgtttt tcccgaaccg aatgccccgt 321301 ttatccaaat gatcatcgcc atttctccct tcctatttat catacagaaa aagacccttc 321361 catcgaagag tcagctggaa aaacaataaa ggcggaaggt tttaacgctt ttttgcgtcg 321421 aagtattaaa atacctgcag aaatgttgta caatgaatgt cattcaggca aaaatggcta 321481 caacaaagcg cactataagc ttgaccggta aagccggtat ctatataaat attcgctaaa 321541 taagcatata atgaatatat aatttcattc cttaggagga tttcgccgaa gatgaacgct 321601 aaacgagcca tcccagtaag agaaagaaat atcgtcctga tcggattcat gggtgtagga 321661 aaaacaacaa tcggccaatt ggtcgctaaa aaattatata gagattttat tgatattgac 321721 cagcagatcg aaaaggattt caatatgtca attcctgaga tatttgagaa aaagggagaa 321781 gactttttcc ggaaaacgga gaaggaatat attttagaca tctgccatca taaacgattc 321841 aaaatcgtat ctctgggcgg gggatctttt aaacaagaag aaatcagaaa ttgctgtctg 321901 gaaaactgtc tcgtgcttca tctggacctg tcatgggaga actggaagca gcgcgcggat 321961 ttattgatcg aaagccgccc tgtactgcat aaccgttcaa tggatgaaat ggaacagctg 322021 tttaacgaaa gaaaagtcat ttatgacaag cacaattcaa aagtggcaac agacaacctt 322081 tccccggaag aggttgccga ttacattgtt gagacattaa aaattggctg ggatctttat 322141 cagccgatgt aaaaagccgt gcgcagcgca cggctttttt tatcgtttta tcccttgtat 322201 caaaatcgct tttaaacaaa aggagatggg ctgtccgttt tggttcaatg taatacagaa 322261 cgtgtcgcgt gcttcgtctg atgcgtgatt caagtgggta atgatttgtt tttctcggtc 322321 agcgggggtt ccgcctcgtt tgatccagct atcgtattga atcggcaagt tccacttttg 322381 gatgtcttga taggccagtt gattggcgct gaacatcgcc tgccattctg ataatgagct 322441 ttcacgaaca tgggaagggt ctcgaagccg gttcaaatga ttgacaaact catcaagaac 322501 gggatcttca ggcgcgtaat gatcaactaa gagaaaacgt ccgtcctgtt ttagtacgcg 322561 tgcaacctct ctgacagctt tgcggacatc tgaaaaatgg tgggctgcgt atcggcaggt 322621 gatgatgtca aatgaatcgt cggggaaggg gagtgactct gccgttcctt gctgaaagcg 322681 tacgttttca actccttttt cttgcgcgaa ggaggacgca acctcaacca tctctttcgt 322741 tgcatcaaca ccgatgcact cctgtacata aggagaaaat gccagcgccg tatggccggc 322801 gcccgctcct atatccagca ctcgatgctc tgcccggcat tccgctgttt tgatcatcaa 322861 ccccaaatct tccccctcgg caaatacctt ttcatcccga tacatctcgg cgtttttaga 322921 aaacggtgtt tcatttgtca tttgaaccag ctccttcttt tcgtaaatga tgatatggat 322981 tatgttagca atttctgtta tgattcgtcc aagatataaa aatgatgaaa atgataggtt 323041 caacctatgg aggctgaaat ggatattaaa gtgatggaat atgcagcgga aattgcccgg 323101 cgccaaagct ttacaaaggc ggcggaacat cttcatatcg cacagccgtc tctcagccag 323161 caaatcaaaa agcttgaggc tgagctgggg cttacccttt ttcacagatc ccatggctct 323221 gttacactga cacctcacgg caggcgtttc attgaaaaag ccgaggacat cattcgttcc 323281 agagatgatt tgcttcggga aatgcaggag cgatcacagg gaatcggtca taaattatcc 323341 atcgggattc ctgctgtaac agggagatat ctctttcctc cgctgctgaa gcagtttttg 323401 gcgcgctatc ctcatgtgga ggttcagctt gttgaaaaag atccggtttc attagagaag 323461 atgacggcaa agggagaagt tgacctttct gttttatcct tgcccatcga ggatgaacgg 323521 ctctccatta cacccttgct cacggaaccg gttgttctcg cggtgccgaa ggaaaaacaa 323581 aggtggatgc cgccggaatt ggtcgcgctg attgagaaag cgctggaaga agatgaggga 323641 cgccagccgt gtgtgccgat tgacatggta aggaacgtgc cctttattct gttaaaagaa 323701 ggcttcggct ttcgcaggac agttctcgat ctctgtgcgg aaagcggctt taagccgaat 323761 gctgccttta agacgagcca tattgaaacc gcccaatctc ttgtggctaa cggattaggt 323821 gtgacaatgg caccgaatat ggtcagaagg gataaagatc cgggtgtgat ctatttatcg 323881 attcaatccg cgccatcacg aaccctcgtc tttgtctttt taaagaaccg ctatgtcagt 323941 ctgacggccc aggcctttat ggaactaagc cgggaaagtc ttaaacaaac gtttgatgaa 324001 ggctgtctgg gaaacaaaga tgaaaatatt tagaaaacaa agacgaaacg tggtagtata 324061 ggaatacaaa ctaaatctta taaaacaaag gggaataatc ggaaatgcaa ctattcgatc 324121 tgccgctcga ccaattgcaa acatataagc ctgaaaaaac agcaccgaaa gatttttctg 324181 agttttggaa attgtctttg gaggaacttg caaaagtcca agcagaacct gatttacagc 324241 cggttgacta tcctgctgac ggagtaaaag tgtaccgtct cacatataaa agcttcggaa 324301 acgcccgcat taccggatgg tacgcggtgc ctgacaagga aggcccgcat ccggcgatcg 324361 tgaaatatca tggctacaat gcaagctatg atggtgagat tcatgaaatg gtaaactggg 324421 cactccatgg ctacgccaca ttcggcatgc ttgtccgcgg ccagcagagc agcgaggata 324481 cgagtatttc accgcacggt cacgctttgg gctggatgac gaaaggaatt cttgataaag 324541 atacatacta ttaccgcggt gtttatttgg acgccgtccg cgcgcttgag gtcatcagca 324601 gcttcgacga ggttgacgaa acaaggatcg gtgtgacagg aggaagccaa ggcggaggtt 324661 taaccattgc cgcagcagcg ctgtcagaca ttccaaaagc cgcggttgcc gattatcctt 324721 atttaagcaa cttcgaacgg gccattgatg tggcgcttga acagccgtac cttgaaatca 324781 attccttctt cagaagaaat ggcagcccgg aaacagaagt gcaggcgatg aagacacttt 324841 catatttcga tattatgaat ctcgctgacc gagtgaaggt gcctgtcctg atgtcaatcg 324901 gcctgattga caaggtcacg ccgccgtcca ccgtgtttgc cgcctacaat catttggaaa 324961 caaagaaaga gctgaaggtg taccgctact tcggacatga gtatatccct gcttttcaaa 325021 ctgaaaaact tgctttcttt aagcagcatc ttaaaggctg ataaatgtga aaagccgccg 325081 catatcatca ggcggttttt ttctgcaaac tgccggaatg agaacagact ggagacgaat 325141 agatatgaaa caaagaatca ttgatgaatt aaaacggatc gagcagtcat acggagtcaa 325201 aatcgtgtat gccgtcgagt caggaagccg cgcatgggga tttccctcgc aggatagtga 325261 ttacgacgtc cgctttattt atgttccgaa aaaggagtgg tacttttcaa ttgagcagga 325321 gcgtgatgtc attgaggaac cgattcacga tttgctggat atcagcggct gggagctgag 325381 aaaaacgctt cggcttttca aaaagtcaaa ccctccgcta ctcgaatggc tgtcctcaga 325441 cattgtgtat tatgaagcat ttacgaccgc agagcagtta agaaaactcc gcacggaggc 325501 atttaagcct gaagcaagcg tgtatcacta tatcaatatg gcgagaagga acgtcaagga 325561 ttatctacaa ggacaagagg tcaaaattaa aaagtacttc tacgttcttc ggcctatttt 325621 ggcctgccaa tggattgaaa agcacggaac cataccgcca atggacttta ctgttttgat 325681 gaatgaactt gttgctgaac ccgagctgaa ggctgaaatg gaaaccttgc ttgaacggaa 325741 aagaagaggg gaagagcttg acctcgaagc aagaatcgat gttattcacc aattcattga 325801 aacggaaatc gaaagaatca tggaagcggc aaaagaactg aaggcagaga aaaaagatat 325861 gacatctgaa ttgaaccgtt tgcttttgaa tacggttgaa gaagtgtgga aggatggagg 325921 aagctgatgt tttttgtcgc ttccttttct cctttattcg acagaatccc cccccgactt 325981 tctaactatc tgattgtggc aaacccacaa aaataatcag aatctttgta ttttgagaat 326041 attgtgaacg ctggttttgt ccatttacaa taaactcata caaatacttc ttagattgcg 326101 gggtgttgag gttggaagtg atcacaagag attttttctt atttttatcc aaaagcggct 326161 ttctcaataa aatggcgagg aactggggaa gtcgggtagc agcgggtaaa attatcggcg 326221 ggaatgactt taacagttca atcccgacca ttcgacagct taacagccaa ggcttgtcag 326281 ttactgtcga tcatttaggc gagtttgtga acagcgccga ggtcgcacgg gagcgtacgg 326341 aagagtgcat tcaaaccatt gcgaccatcg cggatcagga gctgaactca cacgtttctt 326401 taaaaatgac gtctttaggt ttggatatag atatggattt ggtgtatgaa aatatgacaa 326461 aaatccttca gacggccgag aaacataaaa tcatggtcac cattgacatg gaggacgaag 326521 tcagatgcca gaaaacgctt gatattttca aagatttcag aaagaaatac gagcatgtga 326581 gcacagtgct gcaagcctat ctgtaccgga cggaaaaaga cattgacgat ttggattctt 326641 taaacccgtt ccttcgcctt gtaaaaggag cttataaaga atcagaaaaa gtagctttcc 326701 cggagaaaag cgatgtcgat gaaaattaca aaaaaatcat ccgaaagcag ctcttaaacg 326761 gtcactatac agcgattgcc acacatgacg acaaaatgat cgactttaca aagcagcttg 326821 ccaaggaaca tggcattgcc aatgacaagt ttgaatttca gatgctgtac ggcatgcggt 326881 cgcaaaccca gctcagcctc gtaaaagaag gttataacat gagagtctac ctgccatacg 326941 gcgaggattg gtacggctac tttatgagac gccttgcaga acgtccgtca aacattgcat 327001 ttgctttcaa aggaatgaca aagaagtaaa aaaggagaga ttatcatgac aacaccttac 327061 aaacacgagc cattcacaaa tttccaagat caaaacaacg tggaagcgtt taaaaaagcg 327121 cttgcgacag taagcgaata tttaggaaaa gactatccgc ttgtcattaa cggcgagaga 327181 gtggaaacgg aagcgaaaat cgtttcaatc aacccagctg ataaagaaga agtcgtcggc 327241 cgagtgtcaa aagcgtctca agagcacgct gagcaagcga ttcaagcggc tgcaaaagca 327301 tttgaagagt ggagatacac gtctcctgaa gagagagcgg ctgtcctgtt ccgcgctgct 327361 gccaaagtcc gcagaagaaa acatgaattc tcagctttgc ttgtgaaaga agcaggaaag 327421 ccttggaacg aggcggatgc cgatacggct gaagcgattg acttcatgga gtattatgca 327481 cgccaaatga tcgaactggc aaaaggcaaa ccggtcaaca gccgtgaagg cgagaaaaac 327541 caatatgtat acacgccgac tggagtgaca gtcgttatcc cgccttggaa cttcttgttt 327601 gcgatcatgg caggcacaac agtggcgccg atcgttactg gaaacacagt ggttctgaaa 327661 cctgcgagtg ctacacctgt tattgcagca aaatttgttg aggtgcttga agagtccgga 327721 ttgccaaaag gcgtagtcaa ctttgttccg ggaagcggag cggaagtagg cgactatctt 327781 gttgaccatc cgaaaacaag ccttatcaca tttacgggat caagagaagt tggtacgaga 327841 attttcgaac gcgcggcgaa ggttcagccg ggccagcagc atttaaagcg tgtcatcgct 327901 gaaatgggcg gtaaagatac ggttgttgtt gatgaggatg cggacattga attagcggct 327961 caatcgatct ttacttcagc attcggcttt gcgggacaaa aatgctctgc aggttcacgt 328021 gcagtagttc atgaaaaagt gtatgatcaa gtattagagc gtgtcattga aattacggaa 328081 tcaaaagtaa cagctaaacc tgacagtgca gatgtttata tgggacctgt cattgaccaa 328141 ggttcttatg ataaaattat gagctatatt gagatcggaa aacaggaagg gcgtttagta 328201 agcggcggta ctggtgatga ttcgaaagga tacttcatca aaccgacgat cttcgctgac 328261 cttgatccga aagcaagact catgcaggaa gaaattttcg gacctgtcgt tgcattttgt 328321 aaagtgtcag actttgatga agctttagaa gtggcaaaca atactgaata tggtttgaca 328381 ggcgcggtta tcacaaacaa ccgcaagcac atcgagcgtg cgaaacagga attccatgtc 328441 ggaaacctat acttcaaccg caactgtaca ggtgctatcg tcggctacca tccgtttggc 328501 ggcttcaaaa tgtcgggaac ggattcaaaa gcaggcgggc cggattactt ggctctgcat 328561 atgcaagcaa aaacaatcag tgaaatgttc taagcgggac taaatgggca tcctccctgc 328621 gggggtgtcc atttcatcca tatactataa aaaagaggag gaagtgccat agaaaacaca 328681 cagctgatta tttcgatttg tatttatatg gcgggaatgc tgctaatcgg ctactttgct 328741 tacaagcgta cgtcgaatct gacggattat atgctgggag gacgctcttt gggtccggca 328801 gtaaccgctc tcagtgccgg cgctgccgat atgagcggct ggctgctaat ggggcttccg 328861 ggcgccatgt tttctactgg tctgagcggc gcttggatcg tcatcggact ttgccttgga 328921 gcgtgggcga actggcttta cgtcgcacca cggctgagaa cctatactga aaaagcgggg 328981 aattctatta caattcccgg attcctggaa aatcgcttcg gagatcaaac aaagcttctc 329041 agactgtttt cgggaattgt cattttagtc tttttcacgt tttatgtatc gtccggaatg 329101 gtgtccggcg gcgtcttatt caacagcatc ttggggatgg attatcacac cggcctgtgg 329161 attgtgacgg gtgttgttgt ggcatatacc ctgtttggcg gctttttggc agtcagctgg 329221 acagattttg ttcaggggat tattatgttt gccgcactca ttcttgtgcc gatcgttacg 329281 tttttccaca cgggaggagc aggtgataca gttgctgaaa tccgctctgt agatcctgat 329341 atgtttaata ttttcaaagg aacgagcgtc cttggcatta tttctttgtt tgcctggggg 329401 ctgggatact ttggccagcc gcatattatt gtgcgtttta tggcgataac gtctgtcaaa 329461 gagatcaaaa gagcgcgcag aattgggatg ggctggatga ttttgtctgc agtaggcgca 329521 gtgctgaccg gtttgggcgg aatcgcttat taccatcagc gcggcatgac actgaaggac 329581 ccagagacga tttttattca attagggaat atcttgttcc atccgattat cacgggtttt 329641 ctgatttcag cgattttggc cgcgattatg agtacaattt cttcccagct gcttgtgaca 329701 tcaagctctc tggtagaaga tttgtataag tcgatgttca gacgctcagc ttcagataaa 329761 gaactggtgt ttttaggccg actggctgtt ctggctgttt caattgtcgc gttggttctg 329821 gcttgggaga aaaataacac catccttgga ttggtcagct acgcgtgggc gggcttcggt 329881 gcatcattcg ggccagttgt actgctcagt ctgttttgga aacgaatgac caaatggggg 329941 gcactcgccg gcatgattgt gggagcagcg actgtaatca tttgggcgaa tgccggtctt 330001 tcggactttc tgtatgaaat gatacctggt tttgctgcga gtctattatc tgtctttttt 330061 gtcagcatat tgacgcaggc tccgtcacaa gctgtcacag accagttcaa cgactaccaa 330121 gatacaatgt cgcaataaag atcgaaagga ggaggaaggg gctgtccctt tttcctcttt 330181 tctcctttta agcggccatt tttttctttt ggaaacaaac gtattttttt ctatacaaaa 330241 agaccccgta tggatatgat taaagtaaaa aaagtatagg agaaaaaggt atggaagagc 330301 ttttagagag agttttttca ttttcagatg ttgataagct aattgatttt attagctatg 330361 aactgcaaaa gccagtgata ctggaaagcg cggatttctt tttgttagcc tataattctt 330421 actatattaa ccattttgat tctgccaacc agcagactat tttttcgaaa aagtgtccgg 330481 tccagatttt tgagaggttt ctgaaggacg gaattattga aaaattgaaa acagagcctg 330541 agccttttcg cgtcaataaa attgaaagca ttgggttaaa ccagagggtg gtcgtgagtg 330601 caaagcacaa aggggaagtc atgggctaca tctggattca ggagctggac caaaatctga 330661 cggatgaaga gctcgacttt ttgtacgaga cctccttcca tgtcgggaaa atcatttata 330721 aaacgaataa attgaaacag gaaaaggaag aaaaagcaga ggatctcatc aaacgggcga 330781 tctatcagca atttacctct gagaaggaac tcagacggga agctgaaagg atcaacaccg 330841 tgctgccttc catgttttca gttgttatcc tgcacgccgc aaatggggat ggggaagcgg 330901 ttgaggattt aaaggaaaat atcaggtcgt acctgaattt acgggataag gtcagtcatg 330961 tcttaacgat cgaatcaaac attgtcatcg tcgtagcgag tttttcccaa aaaagctccg 331021 tctcctcagc agcttctgag tttattaaca agctgttaac acattttcac tttcaaaaaa 331081 tacctacccc tatttatatc ggtatcggaa acgaatataa tcacctatta aaacttggca 331141 agagctacac agaagcactt gaagtcatca aagccgcaga aatcaccggc aatcaggaaa 331201 acattccata tgaatatgcc aaactcggca tttaccgcta tttagaaagc atcgaacaga 331261 aaaatgaatt tttagaatac gagaataaag atttagcttt attaaaagca aaagacgaag 331321 aaagcagcac tgagctgctc aaaaccttgg aaatctatct cctcaacaac tgcaaaacaa 331381 aaccagcggc agaacagctg tttattcacc aaaatacatt gaattaccgc atcaaacaga 331441 ttactgagat gacgtcgatc gatttaagcg atttcagaac gcggtgccag ctctatctcg 331501 atttgatgct gatgaaaaag aaataaaaaa gaaaccagta cttgtactgg tttcgtcttc 331561 acttaaaatc ctctgtaaac atacggatca tcaggttttt taatggtatt ccagtcagtt 331621 actttgacga cagggagagt tgacttgaat ggctggtaat attctgaggc cagagtgccc 331681 ttaatgtgaa tccattcatc atccttgatg tccatgtcct tcggaaattc cacaagcatc 331741 ccgtacacgc cggaatcagc gatacagtga atgatgccaa accttaatac gaacagctga 331801 tttttgttaa ttgcgtttcc tttgtaagca aatccatgaa attctatcgt ccgtccgaga 331861 aattcacccg gatagttata gatggtttcc attcctttta ggaaatcgtc atcggtcaga 331921 gaaatctctt ttttgctgga atacttatta aacagctgtt tcatttgttt gtcatagctg 331981 tcttgcgcgt aataaaggct ggcatcaggc cgcaaatact gtgtttggga gtagtgatct 332041 ccgctctcca tcgccttaaa cgagaaccct tttgttttga ctatggatga gtcaagcgtt 332101 gcaatcggga agaagatgcc tgacaccaaa ggaaaaagaa aaacaacata aatcaaataa 332161 cgctgataaa atggcttgtt ttgttcatgg tcatgctcgt gatcatggcc gcacccgcaa 332221 tcatggtcat ggtgatgtcc gcttttttca ggcgacttga taaatagata tgcttggacg 332281 gcggtcagaa tggccagcag gaagatcgca ataaaggaaa gataggcata tttcatattg 332341 atatattttg ttagatttcc tgaggcatgc agatgataaa agaaaaacgt aaatcccatc 332401 agcaccaata aacgaaacat ccaatcaccc ctttaccagt agtgatcccg ctaaaacaat 332461 cacgacaatg tatgtaatca gcaggaaaac aaatcgtttt ttgaaggccg caagcatcat 332521 caatagattc ttaatatcca ccattgcacc aaagacgaga aaggcgatta acgatcctaa 332581 tgaaaacgtg ctgctgaagg aagacgcgat gaacgcatca acttctgaac aaagcgacag 332641 gacaaacgcc agacccatca tcacgaggga agaggataca tcattctgcc cgatcgcaag 332701 cagagtggat gttttgacat acgtctgcat agcggctgcg ataaaggcgc cgatgattaa 332761 atatttcccc acggagaaaa attcatcaat ggcatgccgc aaggtcccgc ccagtttttg 332821 gagcaaggtg ccgtgatgat gatggtggtg cccgggttca tcaggcttta aaagctggtt 332881 atccttaaat tgataggata agatgacccc gatgatcagc gaaacggcga gagccagtcc 332941 gcctctgtaa aagaccacgc tccatctatt cccgaacgca atataagtag aaaataaaac 333001 gataggatta atgataggcg cggtcagcat gaaagcaacg cccgcatgca gaggaactcc 333061 ctttaacaga agccgcctcg taatcgggat gatgccgcat tcgcaggcgg gaaataaaac 333121 gccggccagc gcaccgaata aaacggcgag aaaacggttt ttcggcatga ttcttgcaat 333181 catttcttca gaaacaaaca tttgaatgat tccggaaagt atgacgccaa tcagaataaa 333241 cggaatggct tctattaaaa tgctgataaa aatagaattc agctgaagaa aagatgattg 333301 tgctgtcaca ataaaacctc cgctcatgtt aagctgcctt tcttatgata ccagaaaaaa 333361 aggcactgct tgtttgacgg aggaggggaa aggatcgttt cactttggtt aggattccaa 333421 aaagccgagt aggatactgc ctgtttctgc agcttctttt ccgagccaaa tcaggtgtcc 333481 ccatgagtga agcaaacaga gaacagcgcc acgaatgtgc tcttttgcat gatgtgcatg 333541 tgacaagtca accaatccgt cataaacact ttgcataatc agcacgggac atatgatggc 333601 ttgcaggtct tttaaagaga cagcggcggt ttgtgacaag tcaatcagaa atccttcacc 333661 cgagcgctgc cggctgttca ttttccgaaa tgcttctatg tctttttcat tcatcaagga 333721 cttgattcgc tgaaacggaa gcgtgctgaa ttgggggctc atagctcgaa acatcaaacg 333781 cgggaaagcg ttattcaagg aagaaatcag cttccatatc cacttttcca ccggcgggcg 333841 gaagagaatt tcccccaatt tatattcagt gtcttttggg gtgagccact ctttggtgac 333901 tgcggattgc agggtcaatg tatttactct ttccggataa tgtgaggcaa agcatatgcc 333961 gctcggccct cctgctgaga tggcgatcac atggacactc tcgatttgta gatgatctaa 334021 taatttcaca tagaaacggc aggcattggc aagacttttt ccaatttctt ttgacgtccg 334081 tccatagcca ggccttgaag gcgtaatgat ggaataccct tgttcaatca acgctgtgta 334141 tccgaattcc tcgtaacaat ttgaatgccc gccatgcatg acaaggatcg gagttccctt 334201 gcctgtcaca gaatattcta gtgtaccgcc atcgaaggtg atcgtttcaa ctcgtctttt 334261 catctgtttc acccaattgg tttttgccta ttatagagtt ttcagcaatt gaccacaagg 334321 tagaagaaat gaataaacaa aggcccttga aatatgatat actttgtatt gatattcatt 334381 ctcaattaaa actttgatat agatgtgaac gggaggcagg acggatggct gagaatcaag 334441 aggtatatga cgttacgatt ataggcgggg ggccgatcgg gctgtttact gctttttact 334501 gcgggatgcg ggagctgaaa acaaaggtaa tcgaattttt gccgaagctc ggagggaagg 334561 tgtctttatt ctttcctgag aaaatcattc gcgatatcgg cggcataccg gggattgcgg 334621 gaaagcagct gatcgagcag ctgaaggagc aggcggcaac gtttgatcct gatatcgtat 334681 tgaatcagcg tgtgaccggg tttgaacgcc tagatgacgg caccattgtt ctgacgggtt 334741 ctgaagggaa aaagcactat acaagaactg tgattttggc ttgcggcatg ggtacacttg 334801 aggtcaatga gtttgacagc gaggatgcgg cccgatatgc gggcaaaaat cttcattatg 334861 gagtggagaa gctcgatgcg tttaaaggga aacgcgtggt gatatcaggc ggcggagata 334921 ctgcggtcga ttgggctaat gagcttgaac cgattgcggc gtctgtgact gtcgttcatc 334981 ggcgtgagga attcggcgga atggaaagca gcgtgacgaa aatgaagcaa tcatcggtgc 335041 gggtgcttac gccttatcgg ctggagcagt tgaacggaga tgaagagggc atcaaaagcg 335101 tgaccgtttg tcatactgag tctggccaga ggaaagacat agaaattgat gagctgatca 335161 ttaatcatgg gttcaaaatt gatctcgggc cgatgatgga gtgggggctg gagattgaag 335221 aaggaagggt gaaagctgac agacatatgc gaacgaatct tccgggcgtg tttgtggcgg 335281 gcgacgcggc tttttatgaa agcaagctga gattgattgc cggcggattt acggaaggcc 335341 cgacagcggt caacagtgcc aaggcttatc tggaccctaa ggccgagaat atggcgatgt 335401 attccaccca tcataaaaaa ttggtgcata aataaaacag cccttgagga aaagggctgc 335461 ttgccatcag gtgtgaagga gttttttctc tgcatgttga ttgtggatga aagctagcaa 335521 ttcatcctgt tcttgtacgg ctgtgaatcc ataaatgccg gcagctgagt catcgcctat 335581 gcagacgata ggagggcggc ttgctgacgg ttccggcaaa atgccaattt gttcgccacc 335641 attgatcaat tgctgaacgg acagcttgtt tgggcaaatg accatgtgca gcggggattc 335701 actgatggta cgctgaatca tgtgggtgaa ccggtcatct atgacgtttt catgagtgat 335761 ataaaacgaa caggattcat gcttttgcat gttttccact gcatggcggc tcccgacaac 335821 aagacgtttc tctgaatcag gctgaatggc ggtgacaaga aagccccgtt tctcaagctc 335881 tgtctttgct tgctcagatg ctgcactcag tttggctgtc agctggcgga tgtcgatttt 335941 ctgagaagcc agtgctctga aaaattcaca aaccgcccgg cgcgatgtga aaaaaacgtc 336001 ttcaaaggtg ccaatctttc gaagaatttc ttcattgaca ggcatgtttt cggtccgcca 336061 tttcggccac tcgatgagat cggcgccgga atcgcgcagc ttgtctgcaa gcgggtcttc 336121 atcttcgcca tgagtcacaa ccatcaaatg ccgtccgatg agcggtttgc tttcaaacca 336181 gctgtgtgtt tgaaagttga cgatgtctcc gatgacgata atcgcagggt ttgtaatctg 336241 gtgttcctgc actttttgct gaatgttctc aagtgttcct ttcacactcc gctggcggcc 336301 ccacgttccc cattggatga caatgacagg gacagaaggc gatttcccgt atgaaataag 336361 ctgctggcaa atataagaca agttcttgac acccatgtaa aaaacaaggg tttgaacgct 336421 tcgggccagc ccttcccagt caaggttcgg cgtgcctttt aatgatttat catgcgctgt 336481 aatcatggca aaagacgatg caaaatcccg atgcgtgacg gggatgcccg catatagcgg 336541 cgctgcaatt ccagaggtga ttcccggcac catttcatag cgaatgccgt gctcatgaag 336601 agcatctgct tcctcgccga ctctgccgaa tacgctcgga tctccgccct tcaagcgaac 336661 gacggttaac ccatttaatg ctttttcaac cagcagggcg ttaatttctt tttgtttcat 336721 aaaatggcgg tttggcagtt ttccgcaata aataaactgg cagtccggtg atgcaaattc 336781 gagcagcttc gggttggcga gccggtcata taaaatcaca tctgcttcct tgagcgcctg 336841 ttttcctttg atggtgagca ggcctgggtc gccgggtccg gctcccacga aatatacgat 336901 tccgttcttc atgatcatgt catccttccg tcactgtaaa aaatgaagga ccactagaaa 336961 agtgatccgg tcttttgatc aatatacgag ataaacatgt tctccttcga tcagcgtttc 337021 atatgttttg acgcatccgt ggtcaggttc ttggacgatt ccgtcttcta aggaaatttt 337081 ccagtcgtgc atcgggcaga aaacatattg accgctgacg atgccttctg ccaggacgcc 337141 gcccttatgc ggacagcggt tttcaatggc gcggatgctt ccgtctgaaa gcttgaaaac 337201 cgcgagctcc ttatcttcaa tatacactgt tttgcctaat tgttcaggca attcttcaat 337261 ttttccgata catacttttg ttacgtcttt gtttaccatg tccattcctc ctcaatgata 337321 gtttttgtca ttatgatgtg gtcacgacat tttcaaataa ttctttagag gtttgtttat 337381 cctctaaaaa gtctttccac ggatccttgt ggacagagag tgtttcattc attcggccgt 337441 tcagctcctg ccgcttttcc ggatcgttta acacggattg gacatgggat aaaccgacgc 337501 gctcaagcca tgcggacgta cgctccagat agtttgcggt ttccctgtaa tattgcaggt 337561 aagcgcccgc gtattctaag acttcttcat ttgttttcac cttcatcagc aaatcgccgg 337621 cacgcaaatg ggttccgccg tttccgccga cataaagctc ccagcctccg tcgatgccga 337681 caacgccaag gtccttaatg ccggattccg cacagtttcg cgggcaggca gacacggcca 337741 ttttgacttt gtgaggcgtg ttcagccctt cgaatttttt ctcaagcgca atgcccagtg 337801 ccatggagtc ttgtgtgccg aagcggcaga attgctcgcc tacacatgtt ttcactgtgc 337861 ggagcgtttt tccgtacgcg tagcccgatg gcatatcaag atcttcccat accttcggaa 337921 ggtcttcttt tttcacgccg ataagatcaa ttcgctggcc gcctgtcatt ttcacgagcg 337981 ggatctcata tttgtcaacg acatcggcga tcttgcgcaa atctgtggag ttggtcacgc 338041 cgccgtacat ccgaggaacg actgagtatg ttccgtcttt ttgaatattg gcgtgcattc 338101 gttcattaac aaagcgggat gtccggtcat cctcgtattt ggttggattg atcatgccta 338161 agtagtagtt cagagcgggt cggcatttag aacagccttc tggcgttttc cagccgagca 338221 cattcatgac ttctcttgta tgtgacagcc ctttggcttt gatttcttct acgacttcat 338281 ctctcgacaa tgtggtgcag ccgcaaatgg cttctttttg cgctgacgca tcaaagtctg 338341 atccgagcgt atgctggagg atttcttcta cgagcggctt acagcctccg catgagcggg 338401 atgcgccggt gcatgctttg atttcgtccg ttgacgagca gcccttttcc tgtatggctt 338461 gaataatcgc accttttgac acgccgttac agccgcagat gatttcatcg tcgctcatcg 338521 ctgcggttat gcttgtgcct gcttcctggc tgaggggctg taagattgat attttagagg 338581 tttcagagat atcggcttct ttttgaatca tagaaaacag gcgattgcct tcgctgctgt 338641 cgccgaataa aacagcaccg acaatttgat tgcctctcag gacaattttt ttatagatgc 338701 cgtcctgctc atcgaagact ttaatcgctt ttttctcctc tgattcgtta aagtcaccgg 338761 cagagaagac ctcgacgcct gataccttta actgtgtgga gagaacggag ccctcatacg 338821 gttttgtttc gatgccgcac atatgctttg ccagcacttt tgcctgttca tacagcggcg 338881 ccacaagccc gtaggcgatt cctcggtgct cggcacattc gccgaccgcg taaatgtgcg 338941 ggatttcagt ctgcatataa tcgttgacga tgatgccgcg gttaaccgga atgccgctct 339001 cggccccgag cgttgtattt gggcggatgc cgacagccat gacgactaaa tcagcttcaa 339061 tgcttgtgcc atccttgaat cggaggcctt cgacacggtc gtcaccgaca atttcttctg 339121 tttgcttttc aagtaaaaag gtcatacctt gtttttctaa ctcgttttgc agcaggcgtc 339181 ctgccgttgc atcaagctgg cgctccatca ggaatggggc aaggtggatg acggacacgt 339241 ccatgccgag attcagcagt ccgcgagctg cttccaaacc aagtagtcct ccgccgatga 339301 cggcagcttt tttatattgt tttgacgcgg cgagcattgt gtctgtatct tttatgtccc 339361 ggaaagctgt gacgcctttt ttgtctgcgc ccggaatcgg aaggataaaa gggaccgatc 339421 ctgtcgccag gatcaattca tcgtaaggct ggattctgtc tgcatctgtg atgactgttt 339481 tgttttccgt gtccactttg atgactgttt catttgtata caattgaatg ttgttttctt 339541 cgtaccagtc ccaatcgttt aacgtaatat ctttaatatc tgtatcgcct tgaagcactt 339601 ttgacaaaag gattcggttg taattgggat gcggttcggc accgaaaatt gtgatctgaa 339661 actcgtcttt agcaacactc agtatctctt caatggccct taccccggcc attccattac 339721 caacaagaac tagctgtttt tttcccatca gatgatccgc tccttatcaa atgttttttc 339781 cagcgtagca cagcaaaaag gaatatttaa gatacatgtt ataaaatgta acaaaatata 339841 cgaaaagttc taaaaatttt atgaaaaatt taaataggta tgattcggac ggcgcatacc 339901 ttaaaaccgg gcattttaca ggctggatct aaggcttccc cgattaaatc attcacattt 339961 tgagcgtctg cccaatggat gggaacaaaa acggtatctt ttctgatttg ttctgataat 340021 ttgctgcgga cggtgatgct tccccgcggc gattctattt ttaccagtac acggtcctcg 340081 atattgtagg tcgctgctgt ttgcggatgg atctccataa acgattcaaa atgtctcgcg 340141 gcaagggcgg cgctttttct tgtttggacg cctgttaagt agtgagacat gactctgcct 340201 gtcgttaaat aaagcggata atcggctgtc ggcttctctt ttggaacagg tggttcgttt 340261 ggaatcacac ttaatgccgc tttttgatcc ggatgagcaa atgattctgt aaacaagcgc 340321 ccagttccgg gatgatcaga ttccggacac ggccaatgaa tgccgccttc acgtctgagc 340381 ctgccgtatg agatgcctga ataatcggca atcccgcctc ggctcgcttc tctcaattca 340441 ttgaaaatat cctccgctga cgtataagaa aagtagcggc ccttgccgag agcggatgcg 340501 agatcacaaa tgatctgcca atcatgcttt gcttcgccgg ggcatggccg gcttgcttct 340561 cttaatgtca cgcgtccttc tacatttgtc atggtgcctt catcttctaa gtaagaggag 340621 gcaggtaaaa tcacatctgc gtatttcgca gtctcagaaa taaacaaatc gattgcgaca 340681 aagaatgtca gtcttcttaa agcctttttc acgagatttg catttggact ggaaacagca 340741 gggttggagc acatgaggaa cagtcctttg atgtcgccgt cattgatttt ttccatcatt 340801 tcataggctg agacaccttt tcgcgggagt tcatcctgat ggattcccca cactttcgca 340861 atatgcgccc ggtgttcttc gttttcgata gaacggtagc ctggaagctg atcggctttt 340921 tggccatgct ctctggcgcc ttgcccgttg ccttgtccgg tgatcgcccc gtagcccgag 340981 taaggtttgc cgatttttcc tgtgatcagc accatgttta agaagccttt cacagccgct 341041 gttccatcgg tttgctgttc aatcccgcgg gctgtaaaca gcatgccgga cgtttccttg 341101 gcaaacttca cagcagcttt tcttatatcc accagcgaga cactcgtctg ttcggcgatg 341161 tcattcaggt ccaacgagtc agtatgctgc ttcagctctt cgaatccatt tgttcgtgat 341221 tgaatgaaat cctcgtttat aagctgttcg tcaatgatga ttttgacgag accgttggca 341281 agggcggcgt ctgtgccggg tttgattttc agatgaagat cggcgatttt cgttgtcgct 341341 gtttcacgag gatcaatggc aatgaagtaa gctccgtttt ctttcgcttt ttcaaaatac 341401 ggcataatcg taggctggca ttccgcaata ttggtgccgg ccagaatgat cacacgggtg 341461 tgggggatgt ctgataaagg attcgttaag cctctgtccg cgccgaatgt ttggttggct 341521 gcggtggctg ctgcggacat acaaagtctc ccgttgtagt cgatgtattt tgtctgtaag 341581 cctactcgtg cgaacttccc taacaaatac gcctcttcat ttgtaatcga ggcgcttccg 341641 tataccgcca tggcgtcatg tccgtgttca gtttggatca ttgtcacttg gtctttgata 341701 tgattcagtg cttcttccca ggaaacaggc ataaactcgc cgtttttctt cagcagcggc 341761 cgggtgatgc gggaggagtt caaggcatgc tggtgagcat tcatgccctt gatgcatagc 341821 cgaccctgtg tcgtaggatt atcaatcccg atcgcagtgt actttttgcg cgtgacgatg 341881 gtttgttcca cgagctgcat tttgcactgc atgctgcaaa acgggcattg agtgtcatat 341941 gttttttctg attggacgtc ttgctgttta tcacggaaat atctaagcag tcgttcagtc 342001 aaaatgcctc atcctttctt atatgcgccc gtctctacag tcgggttttg aatcagtgac 342061 agatctgttt ggaggctttc cagcagctgt gcccttaggt cttcttcgaa tagcacttct 342121 ctgatatgaa cgatcccgag acggtctatc cactgatgaa caccttctaa gtaatgagcc 342181 gtttcccgat aatactggat cagtcctttg atcatgccgg cagtgctgtc ttcgttctca 342241 gtcacgcaaa acaaagctcc tgaacgggca tgagttcccc ggacgccgcc gatgtgaatg 342301 tcccagccag cttgtgtccg aattgcgccg acatcttgca gggcggcctc ggtgcagtct 342361 gtttcacatg ataagctgat agaaatggga gcgggtaagg gaagcatctc aagttgtctt 342421 tcgatttggg ctgccagctg ctgaatcgat cgattttgcc cgcatgtaca tgctttgatg 342481 ctttgcagcg cgtgtcggtg ttcattagtg taaacgggca ttttcaggtc ttttttcatg 342541 ttcgggagat ccgcaggctt gatcccggaa agcttcagcc tttggccgtg agtgatggat 342601 acgtcgggaa tgctgtatgc ctcaatgatg ttggcgatgg ttcttagctg ctccgcgttt 342661 gtccgcccgc cgtacatttg cggaatcagg atgcatgtct cttcagtggc tggctcaggc 342721 tggacaaacc cagggtacag catttccaga tagtattgaa tcgcaggaac acaagtactg 342781 catccgtttt ttgttttcca gtcaagctgg ttcatcactt ctgccggatt agtgaatggc 342841 ctgcgctgaa gctcagcgat gatgtcgtct tctgtaaaat cagtacagct gcaaaacgaa 342901 ggtgtgctgg cgggcttcgt atattcgctg ttggtcatgt atctcaaaag gtcttcaacg 342961 agcggtttgc atcctccgca ggacccagtg gctttggtgc agtgcttgac ttcctcaaca 343021 gttgttaagc tattcgtgtg caccgcgtct tcaatcgcgc ctttcgtcac tgtgttgcat 343081 tggcaaatcg tttcactgga aggcatggat tcaaataaag ggccgcttgt ctccggttcg 343141 atgatctgtt ttttggcaat ggagatgtct cgttgtttaa gcaggctgtc gagaagccgc 343201 tgcttgtcac gggtgtctcc gaataaaata acgccggcca gtttgtcatc tacaaaaagc 343261 gcttttttat aaacgcctgc ttgttcgtcg tagattttga tgctcgtcgt gcgttcatcc 343321 tcttggatct ttcctgctga ccacacatcg attccagcta tttttaacgc cgcagatggt 343381 gctgagcctt gatattcctc acatggaacg ccgcaaatat gactggcgag cgcttttccc 343441 tgctcataaa gcggagccac caatccgtac accgttccgt tatgctcagc gcattcacca 343501 acggcgtaga tattcggttc gcttgtctgc atgaagtcat tcacgatgat cccgcggttc 343561 actttgattc cagcggatac agccaattca atattcggtt tgacgccggc cgccatcaca 343621 atcaagtctg cttttaatga agagccatct ttaaaatgga ttcggtctgc cttcgtggcg 343681 ccggaaatgg agacggtgtc tttctccaaa agaaaggtta ggcctttttg ttccagctct 343741 gtttgcagca gccgcgccgc tgtttgatcg agctgttttt gcataatgcc ggcggagtgg 343801 tgaatgacgc tgacatccat accgagatgc tgtaaaccta ctgcagcttc cagtcctaat 343861 aagccggctc cgattaccgc agccttttga aagtgctggg ccatgttcat cagcgcttgg 343921 cagtcttcta ttgtccgaaa tccatagaca ccttttttgt ctgccccggg gatagggaga 343981 atatgagggg aggagcctgt tgccactatt aatttgtcat acgacagagt gcgtttccga 344041 tctgtgatga cctgctgctg atctgtatca atctgaataa ccgtttcgcc tgtgtaaagc 344101 gtgatcccgt gcttgtcgta ccaatccttg ctgttcagtg taatatcatc gagtgacgct 344161 tcaccctgca atacagagga taagagaatg cgattgtaat tgggatgcgg ctcgcttccg 344221 aaaatgacaa tctcaaacat gtggcgattc agctttaata cttcttcaat acagcggatt 344281 ccggccatgc cgtttcccgc taacactaat ctttgtttct tcatgtatca gacctccttt 344341 ggcgaagctc gtaagttttc tcctattaaa aattatgtca caatgcattg ttaacgcatt 344401 aaacgtgtca caaaaactta cacatgtctt ttccagaaaa taatggtcct atatccttga 344461 ttcagaaaat gtaaaataat gagggtctag aaaggggaat cttatgaagc tgtcggaact 344521 gaaaactagc ggtcatccac tcactttgct ctgttccttt ttatactttg atgtcagttt 344581 tatgatatgg gttatgcttg gggcgctggg tgtttatatt tctcaggatt ttggcctgtc 344641 tccttttgag aaagggcttg tcgtagctgt gccgatttta tctggatctg tgtttcgtat 344701 cattcttggt attttaacgg acagaatcgg accgaaaaaa acggcagtga tcgggatgct 344761 ggtgacgatg attccgctgc tttgggggac attcggcggc cgttccctga ctgagctgta 344821 tgccatcggg attctgcttg gcgtggcggg agcaagcttt gctgtagcgc tgcctatggc 344881 cagccgctgg tatccgcctc atttgcaggg acttgcgatg gggattgccg gagcggggaa 344941 cagcggcacg ttgtttgcaa ccctgtttgg ccctcgtctg gcagagcagt tcggctggca 345001 cattgtcatg ggaattgcgc taattccatt attgatcgtc tttattcttt ttgtatccat 345061 ggcaaaggat tcccctgcac agccgtctcc ccagccgctc aaaagctatc tgcatgtgtt 345121 tgggcaaaag gaaacatggt ttttctgcct gctgtacagc gtcacatttg gcggatttgt 345181 cgggctctca agctttttat ctattttctt tgttgatcaa taccagctgt caaaaattca 345241 cgcaggggac ttcgttacat tatgtgtggc ggcggggagc tttttccggc ctgtcggggg 345301 cttgatttca gatcgtgtcg gcggcacgaa agttctttct gtattgtttg tcatcgtggc 345361 actgtgtatg gccggagtca gtagcctgcc atctctctca atggttattg ttctattgtt 345421 tgtcggaatg atggggctcg gaatgggaaa cggcgcagta ttccagctcg tgccgcagcg 345481 cttccgcaaa gaaatcggca tggtgacggg aatcgtcggt gcggccggag gaatcggagg 345541 gtttttcttg ccgaacatct taggatctct caaacagatg acaggcacat atgctatcgg 345601 ttttatcacg ttttcctgta tcgcgctgct ggcgtttgca cttgtgcttg ccgcaggcta 345661 ttactggcgg aaaagctgga gcgcggaaag cagcccggcg gatgtttagg attttgacgg 345721 acacgcgttt gtgcgtgtct tttttatttt ctcttgattt tcaacagtga accgatcaaa 345781 ataaatagta attattacga tttgttagtg agaggagttt tctgaatgaa tcaacatacg 345841 ctgctcccga aaaaaacgga gcgtcttcaa tactttggat cggtcagtcc gatcaaaggc 345901 gagaaaccag tggaaaaaga gaaaatgaag gacctgcaaa atatcaggaa ggattatttt 345961 tttgacattc agcatgtagg tgtagctaat gtgtcccatc cagtcacaat cacttctgcc 346021 atgatgcctg ccgagcaaac aacggctgcg aactttacaa tgacttgtaa tttgccgaga 346081 aatcagaagg ggattaacat gagccggtta acagagctgc tgcaagtcta tcatcaaaat 346141 ggctggattc tctcattttc ctctcttcag caatttacga aagagcttgc agaaaacatg 346201 gacacatcat ctgccacagt tgaagtgagg tttccgtggt ttttcgaacg gaaaagcccg 346261 aagcttgaga aagcgggttt gatgcatgct gatatattca tgtctgtcac ctatcgcaaa 346321 gatcagccgt ttaaacagcg tgccggcatc tcagcaaaag taacgactct gtgcccttgc 346381 tccaaggaaa tcagcgaata cagtgcccat aatcagaggg gaacggtcag catttgggcg 346441 gatattcacc cggccgcatc gctgccaagt gatgttaaag ctgatttgct tcacgccgca 346501 gaatcaaatg cttctgcgag actgcatccg gtattgaagc ggcctgatga aaaagccgtg 346561 acagaaacgg cctatgaaaa cccgagattt gttgaggatc tcgcccggct gattgctgca 346621 gatttgtttg agcttgaatg ggtgtcagcc tttgagattg aatgccgaaa tgaagaatcg 346681 atccatcttc acgatgccta tgcgaagctg tgtttttcga aggaagtgga taaaatatga 346741 aactctcatt attcattatt gcagttctta tgccagtcat cctgctgtca gcctgctccg 346801 atcatgcaga agaacacgca agtatcaata caaagaaaac ggtcgaaaac ataacggacg 346861 ttcgaaaaac agcaaaaaca agcattgatt ggacaaagcc ttcgggcgga gaatacccgg 346921 atattaaaca gaagcatgtc tggattgatg tgaatgtgaa ggagcagaag gcttacatca 346981 aggaaggaag caacaccatc tatacaatga tgatttcttc tggtcttgat caaacaaaag 347041 atgatgctac gccaaagggc accttttatg tagagcctga acggggagaa tggtttttct 347101 ccgaaggata ccaggaaggc gcagaatact gggtatcatg gaaaaatcac ggtgaatttt 347161 tatttcatag tgtgccaatg actaaggatc aaaaagtcat caaaacggaa gcagaaaaac 347221 taggaacgaa agcatctcac ggatgtatca ggctgaccat tccagatgcg aaatgggtat 347281 atgaaaatat ccctgaacat acaaaagtgg tgatcagctg aattgaaaac cgttgacaaa 347341 aaggaaaaaa gaccatacaa tttaaatcgt aacaattacg ttttatgata aatggcttat 347401 cattgtctgt gcatctgtga aaagcggaaa ggcatcgatt aaggatcttg ctgtcggcaa 347461 aggcaaggat ttgcgatggg gaaaaggatt aaacgcggtt ggagtcttta ctgatttaga 347521 aatcgggcgg cagcgagaaa tgagcgcgaa aagctgctct acaccattgt acatacggcg 347581 aagtattcaa tttaaatcgt aatcattcta ttttaatgga ggcactatta tgaaaaaaat 347641 tccggttacc gtactgagcg gttatctcgg tgcgggaaaa acaacattgc tgaacagcat 347701 tttgcaaaat cgcgaaggct tgaaaatagc ggttatcgta aacgatatga gcgaggtgaa 347761 cattgacgcg ggcttggtta agcaggaagg tggcctttcc agaacagatg aaaagcttgt 347821 ggaaatgtca aatggctgca tttgctgcac gcttcgcgaa gacttattaa ttgaagttga 347881 gaagctggca aaagacggac ggtttgatta tatcgtcatc gaatcgacag gaatcagcga 347941 accgatcccg gtggcccaga ctttctctta tatcgatgaa gagatgggaa tcgatcttac 348001 aaaattctgt cagctggata cgatggtgac ggttgttgat gccaaccgtt tttggcatga 348061 ttatcagtca ggcgaaagcc ttctggaccg caaagaagca ttgggggaaa aggatgaaag 348121 agaaatcgcc gacctcttga tcgatcaaat tgagttttgc gatgtactga tcttaaataa 348181 atgtgatttg gtcagcgagc aagagctcga acagcttgaa aacgttcttc gtaaactgca 348241 gccaagagcc aggttcattc gttccgtcaa aggaaatgta aaaccgcagg agattttgca 348301 tacagggtta tttaacttcg aggaagcgag cggatcggcc ggctggattc aagagctgac 348361 ggcaggccat gcggaacaca ccccggaaac agaagaatac ggtatctctt catttgtata 348421 taagagacgt ttgccgtttc attctacacg attttaccgt tggttggatc aaatgccaaa 348481 gaacgtggta cgtgccaaag gaatcgtctg gtgcgcatct cataacaacc tcgctttgct 348541 gatgtcgcaa gcaggtccgt cggttacgat tgagcctgta tcttattggg tggcggcgtt 348601 gccgaagctt gagcaggagc aagtcaaaca gcaggagccg gaaatcctgg aggagtggga 348661 cccggagttc ggcgaccgcc taacgcagct agtttttatc ggaactgacc tggatgaaga 348721 aacgatcacg aaagagcttg atcaatgcct gttgactgag tatgaatttg attccgactg 348781 gtcgctgttt gaggacccgt ttaaatggaa gctgaatcaa tagaaaaaaa gccgtcccat 348841 ggggaacggc tttttttaat gaaacgtttg tttaaacata atgagcgtat tttttctcaa 348901 ggatattctg aaagaccgcg gcaatggagc agatggccca ataaatgaga gcggtcagaa 348961 tatacatggt catataatca aactctctgc ccccgatgat tttcgcatgc tggagcaatt 349021 ccggcactgt aatcatcgca gcgagagagg acgccttgat caagtcgagc aatacattgg 349081 caagcggagg cagcgcaata cgtatcgatt gcggcaaaat gatgcccctc atcgtctgcc 349141 aataggaaag acccagcgag gatgcggctt cccactgtcc tttttcgacg gatgaaatgg 349201 ctgaacggtt aatttccgca atgtaggcgg cgctgtttag gctaaagccg attaaagcag 349261 ccgtgacagc ggaaaattca atgccgatat aaggaaaccc gaaataaagg ataaacaaaa 349321 tcaccaaaat cggaacgcct cgcataaatg agatatagag cttcgccggc catcttaaca 349381 aagcaagttt agacattctg gcgagtgata tgaacaggcc gatcacagtt cccgcaaaca 349441 tgcttacaaa agagatgagc agtgtataac caatgccttt tatgacataa gggaacgatt 349501 caatggccag cttcgtgttg aaaatatatt cccactgaat gctattgatc atggcgtccg 349561 attacaaatc aacgtcctga acgtcggcat caattttttt tgatacatct gctttattga 349621 agaattgttt cgacagttta gtcaaagagc catccttgct catctctttc aatgcttcgt 349681 tcatcttttt ctgaagtgcc gcattgcttt ttttcatgac aagggcctgt ttgttcggca 349741 tgtacttgat gtcaggatga attgtaatgt tgagatccgg gaatgccgcg agcgcaagtg 349801 tctgcaggta atagtcgttt aaaatgacgt cagtgcgtcc gttggcaaca tcttttaaat 349861 attgctcatt cgtcgcatta tcataaatca cttctttggc gccgtatttt ctcgcgacct 349921 ccatgtagac ggttgtagcc gcgccagccg ctttcttccc ttttaaatcc ttgagcgttt 349981 taatccctga taaatcgtct tttcggacaa ttgccgtgcc gtatgaatat ttatatggag 350041 tggaaaatgc gaacttctcc tcacggtcct tcgtcacatc gatgtcattc gcggctgcgt 350101 caacctgtcc gctgttcacc gctgtcagca tcccgtcaat gcccatctcc ttgaactcaa 350161 ccttcagccc caagcgtttt gccgcttcac gaacaacttc aacctcgtag cccgtcagct 350221 tatcagagcc agagtcagta tcgtgataag aagtgggata gagcgtacct gatgtagcga 350281 ctacgatttt ccctttatcc ttaatctgct cccagcctgt atccttggaa tcggcttcat 350341 ttttgccgga acaggctgcc aatataagaa agaaagccat tgtgaaactg aatataacgg 350401 ctttggaatg catgaatgat ttcacctata gttcccccaa tctgttaatc aactaaaaag 350461 atagcattga acataagggg ttgcaatatg ttgatcgcgt tttcaaaaag ttcgaattgt 350521 gtatacaaaa agcatgggtg ggtgtttaaa agcgtctatg aagggaagag gtgatgaaaa 350581 aaggaattgt ccaaggatga atgccagacg taccaaggaa acgcatgtga aagtgaagga 350641 tgcagcagac ccgtcactca tctatgccaa taccggaaga aatggtcaag aggcatgaaa 350701 ccgatcttca gaataaattt aagtcttgct gatgccccta aggcatatga tatattcgat 350761 gagaaagaaa atggaaacat ttaaaccata atggggagtc aaatgaatat ttacaaacca 350821 gccggatttt ggatcagact tggagctgca ttgttagact acattatagt ctccgtgccg 350881 cttttgctga tctattggct gattacagga aaagacccaa acgacagcat gttcatcagt 350941 ttggttgttc tgctgtattc tattttgctg ccgatgtttt ggcgcggtta tcttatcgga 351001 aaaaggatct gcggaatcag aatcgtaaaa aaagacggat cacaggtcag tctgttaaca 351061 atgtttttac gggttattgt agccggcctg gtttactgta taaccttcgg actcggcttg 351121 atcgccagcc tgattctgat tgccgtacga gaagacaaac ggaccctgca tgatttaatc 351181 gcgggaacat atgtcactta tgcgacacca ggtgaagagg aacttaatgc tgacgaagag 351241 attagaaaga gcgaataatg gttcgctctt tttattttta tgcataaaaa atacaaggca 351301 gcaaaacata tgaaaaatag gattggagga ataaaatgga tgaaacgaat aaccatcaac 351361 attatcacaa tgttcattgc agcggctgtc atttctctga ccggtacagc tgaggccgct 351421 gaaaaacagc agcagtctcc cgcaaatgtt acactgacag atcagcaaaa gaaagagatt 351481 gaacaactgg aagcagagat tcttaaaaag cgcaaagacg tgatctcaaa gtatgtacaa 351541 tacggtatcc tgcctaaaga aagaggagaa cacatcaaaa atcacttgga caaacacttt 351601 gaaatgatga aacaaaacgg ctttgttcca aagcaccatc ctcatccgca taaatttgaa 351661 aaaagacatt aagattttaa gcatccaatg ggaattgggt gcttttgcgt tatttacagg 351721 taggcaatat tagctgagct gttccgcgac taacatcgag ttgatatgaa acgcgtttca 351781 tagcctatga taggtttatc aaataattca ggagtgataa acactatgat ccaccagcat 351841 ccagaatctt ttccgaaaca ttttttgtgg ggctctgctt ctgcagcgta ccagattgaa 351901 ggcgcttgga atgaagatgg caaaggccct tctgtttggg atgtgtttac gaaaataccg 351961 ggcaaaacgt ttaaaggaac caatggcgag attgcggttg accattatca ccgatttaaa 352021 gaagatgtcg ctctgatggc tgagatgggg ttaaaagcat atcgattttc cgtcagctgg 352081 ccacgggttt ttccaaaagg aaaaggagag atcaatgaag caggtctagc gttttacgat 352141 agtctgattg atgaattgct ttctcatcac atcgagccgg ttctgacttt atatcactgg 352201 gatttgcctc aagcgcttat ggacgaatac ggcgggtttg aatccagaaa catcatagag 352261 gattttaatc actactgtat tactctttat aaacgttttg gagacagggt gaaatattgg 352321 gttacgttaa acgaacagaa ctacaatttt aatcacggat ttattacagc catgcatccg 352381 cctggagtga aagacagaaa acgattttac gaagcaaacc atattgcgtt tctggctaat 352441 gcaaaagcca tcgaatcatt tagagaatat gtgcctgaag gcaaaatagg tcctagcttt 352501 gcttattctc cggcttaccc tttatcaagt catccagagg atatactggc atttgaaaac 352561 gccgaagaat ttacgaacaa ttggtggctt gacatgtatt gctggggaac ctacccgcaa 352621 attccattcc gctgcttgga aaaacaggga tgggcgccga caattgaagc aggagatatg 352681 gacctgctcg ccaaagggaa gcctgatttt gtaggtgtca attattatca gacgatcacc 352741 tatgaacgaa atccgcttga tggtgtgtca gaagggaaaa tgaatacgac aggccaaaag 352801 ggaaccaatc aggagacggg gatacccgga gtgttcaaaa cgaaaaaaaa tccgcatctg 352861 acaacgagca actgggattg gacaattgac ccaattgggc tgcgtatcgg tcttcgccga 352921 attacaagcc gctatcagct tccagtgttt ataacagaga acggtttggg tgaatttgat 352981 aaagttgagg acggcactgt acaggatgat tatcgaattg attatttgcg ttcgcatctt 353041 gagcaatgca gacaagccat cagtgacggt gtcgatttaa tcggctattg cagctggtcg 353101 tttactgatc tgttaagctg gctgaacggc taccaaaaaa gatacggatt tgtatatgtc 353161 aatcgtgatg aagaaagcac atccgattta aaacgcttga agaaaaaaag cttttattgg 353221 tatcaagatg tcatcaagac aaacggagaa agtttataaa gagtccctga gagttattct 353281 ctcaggggtt tttcattaca cagaaacagc atcaataata taagtgtcgg cgtgcaaatc 353341 tgacatttca gccggcacag tccagcatgt caattgatag tctcctttag gcagatcaaa 353401 ggacagtctt ttagacatga tgctttcaat atgaattccg ttttctgtga catgaaaagg 353461 aacagtcact tttttttcgt aggagtttac tgtttctgaa ctgttcaggc gaaaaagaat 353521 aaaggccttt gtatttcgct gtgcctcaaa ggaaatggct ccgtctgccg cagcatatcc 353581 tttttcaatc gcttcgtcag tccaatccat tacaggaggt gtagaatcct tttgaaatac 353641 agtaaattga tgatatgaaa tcgaaagttc ttgcggcttc catgatttga tcaatgtgct 353701 gttcctcctc tatgtactgt ttactgaatt gtgaataaaa cctttgtgcc gtctgggtaa 353761 tcggtaagcc gatgcccgac ccaagagcct gctccgcggt tgtcagcggg agaaatgtat 353821 tctacagaag ctccctcacc gccttctttg cacatggcca ttggccattc atctctgtca 353881 tacccctttt tggaaggtac gtcctttaat gattgctcgc ggcgttcttc agctccgtct 353941 ctgtcaatag tgcacacctc tgagtgcccc tcatttatcg catccttaat atgcttggca 354001 gtttcgggat accggtcaga tgggaaggcc attgtttcat catattcttt cgtttgagac 354061 gttttttgat cagctgagaa aaagtctcct tttatcaggc cgacagctgc agctgctatg 354121 atgacgatga cgagaagtat cgtttttatg atgtccgtcg tgatgttcac ctcccgcttt 354181 taaaactgac acaagagtaa tccagaaagc atttggtgta aaggtttaaa ttttatgttt 354241 tacgatcagt ttattgcaga aatcgtaatt ttagcagatc gaaatatttg ttttcagcaa 354301 aatacgattg ccaatttaca ataatgatag taagtcatca gccgttttcg gcttgattaa 354361 tcattttaaa ttggcttatg ataccggtaa gctcctcagc taattgagaa agtgtttcag 354421 aagctgcggt aatctcctcc attgcagcaa attgctcctc tgttaatgca gccgcttgcc 354481 gggtattttt agtagattct ttaatgtcgg ccgtattggc tgcaaaggaa tcatttattt 354541 gatgtgcact ggctgaaatg tttgttacag atgctgataa atcactaatc tcggcgctga 354601 tttcacctgt tgcagctgca atttccttaa atgcatctct ggtgcgctgg atcatggtga 354661 ctccttctgc agcttctgtt ttcacatgct caacagatct tgcagaccgg ttcatatcct 354721 tttgtatttc tatgatcagt tttgaaatct gccccgcaga ctgttgagac tcttctgcta 354781 atttccgtac ttcatcagca acaacagcaa agccttttcc ttgttcaccg gctctggcag 354841 cttcaatcgc tgcattcagc gcaagcaggt ttgtctgatc agcaatttgg gtgatgaccg 354901 ataaaatttg ctcaatttgt ttagagcggc cgtctaactg gtgtatgatt tctccgcttt 354961 tctgaattga ctggtgaatc gcatccattt gcgcctgtac atttgcaatt tccttttgtc 355021 caatgtctgc ttttgattga gcgagctgcc ctttgtcagc gatagcggca gtatttgcag 355081 aaatatcccg gatgtctgct gaagcttgtt ttaatgagct ttcactattt tcaattcggg 355141 tgatctgatc ttgggctcca tttgcaatct gctgtacagc ttctgtgatt ttttctgaag 355201 cttgatttgt ttcctctgct ccggctgaga gctgctgaga ggctgacgca agctgaaggg 355261 ctgattgttg tacggtttgt atggtatcgt tcagcttcat tctcatctta ttataataga 355321 cgcttagttc tgaaagctcg tcaccggttt tgtctgacac ctctattgtc atatctccgt 355381 ttccggcact ttcaaaggcg ctttttaaag cgttcagccg cttgttgatt tttctggtga 355441 aaaccaagac aaggatgact gataccataa tgacgataac aagaacgata gcgaattgag 355501 tgaaaagtga ttgtgtaagt gatgctaaaa tactttgatt agctccggta tacagcatgc 355561 cgatgatgtt cccattttga tcttttaacg gcatgtatgc agtctgataa gaagaacctg 355621 ctacatctgc ttgtccgtaa aaacgctttc ctttctttaa aacagcggca ataacttcag 355681 aagaagcctg ggtgccgacg gctctttcgc catttttcat gacattggtt gcaacacgag 355741 tatcgccttg gaaaatggta atggtatcac ctgtcttttc accaagcaga tcaacaatat 355801 cttcatttcc attgatttgt gtttgccctt tatagagctt attgtttttc acctgccagt 355861 cgcctgacat gacatcatca atataagtgc tgcttaaagc gagatcacct ttcgcttttt 355921 cagttgccat ttgtttcatg ctttctgtaa tttccttaag catcacagtg ccaactgatg 355981 ccgaaaacaa aagaatcacc acgaaaacga ggcaaagaat tttagttcct agcttcatct 356041 taaatcgttt tatcaacata attcctccct ttacgatttg caggtcatat tacttatcgg 356101 gtttttgggt ttaaagtttt attttagaaa aaataaaacc ggcctgatct tcaggccggt 356161 tgtgtgatgc tattcaaggt ttgcgtggtg agtgaacata gtttcagaat cgagaccttt 356221 tttctccatg agttttaaaa tcactgcatc atagaagagc agcaaagttt gttcaaataa 356281 tgatcccatt ggctgaatgg ttttatagct tccgttagac tggtctttag gggaaccagg 356341 cattctgatg atgaggtccg cttgttttcc gatgcttgat tccggattga tggttaaagc 356401 ggcaacaatt ccgtgtaagc tttttgcttt tgctgcggta tgaatcaagc tctttgtctc 356461 gcctgatcct gagccgataa taactagatc tccttcggcg agcggcggag tgagaatctc 356521 acctactata tgggcgttga agcccatgtg catcagtctc atcgcgaagg attttgccat 356581 caggccagac cgccccgcac ccgcggtgaa aatttggtgg gatgaaagaa tgtgatcggc 356641 aagctggtca gcttcttcat tagaaatata agctgctgaa ttgtgtaact cattgagaat 356701 ttccgctacg tattcagtcg ttttcatcgg agttatcctt ggacaatcag ctgcttcatt 356761 tttgaagctg tttccgcctt atcagctgcg cttgtaattc cgcccccgac aatgacaagg 356821 tcaggctttt gctggatcac ttctggcagt gtatcaagtt tgatgccgcc cgcgattgcg 356881 gtttttgcgt tttttacggt atttttgatt gtcgttaatt cttcgaaaga gtttttgccc 356941 tctgcttgaa gatcatagcc agtgtggacg cagatgtagt caacaccgag tgcgtcaatt 357001 tctttcgcac gggattcgat atctttcacg ttaatcatgt ccactaagat tttcttcttt 357061 tgttttttgg cttcttctac tgcgccttta atcgttgcat cgtctgtagc ccctaaaacg 357121 gtgatgatgt cagcgcctgc ttccgacgct ttcataattt cgtagcctcc ggcatccatg 357181 attttcaggt ctgcaagaac cttcaattga ggaaatgctt cttttatttc tttaacggct 357241 cttaggcctt cattgatgac gaccggtgtt ccgatttcaa ctacgtcgat gtattgttct 357301 acctctttga caagctcaat ggcttccggg atgttgacga ggtctaatgc aagctgtaat 357361 tccattgttg atccactccc tttttcgaat tattgttcat tctataggtt ccttcttttg 357421 ttgagaagta ggcactttga agtcaacaag ttacttggag gatactgtga ggagagacaa 357481 tcagatttct ttcgcttgat tttatgagtg agtataatga aaaaagagtc tgcaaaaaag 357541 taagtaagtg atgatacgta tctaacatac aaaaaggtta ctaagggggg ggattctatt 357601 gagccggatg gacgacaaaa ggtttaattg tgagaaggaa ttaacgcttg cagtgattgg 357661 cggtaaatgg aaaatgctca ttttatggca tttaggaaaa gaaggcacaa aacggttcaa 357721 tgaattaaaa acattgattc ctgatattac gcagaagatc ctcgtgaatc agctgagaga 357781 gcttgagcag gatatgattg ttcacaggga agtgtatcca gttgtcccgc cgaaggttga 357841 atattctctg accccgcacg gagaaagcct catgcctatt cttgaagcca tgtatgagtg 357901 ggggaaaggc tatatggaat tgattgatat cgacaaaaat gtcatgaaag aatcgttgta 357961 agacgctctt cgcaagggtg tctttttttg cctttttttc ggtttttgcg cggtacacat 358021 agtcatgtaa agattgtaaa ttgcattcag caataaaaaa agattgaacg cagcagtttg 358081 gtttaaaaat ttttattttt ctgtaaataa tgtttagtgg aaatgattgc ggcatcccgc 358141 aaaaaatatt gctgtaaata aactggaatc tttcggcatc ccgcatgaaa cttttcaccc 358201 atttttcggt gataaaaaca tttttttcat ttaaactgaa cggtagaaag ataaaaaata 358261 ttgaaaacaa tgaataaata gccaaaattg gtttcttatt agggtggggt cttgcggtct 358321 ttatccgctt atgttaaacg ccgcaatgct gactgacggc agcctgcttt aatagcggcc 358381 atctgttttt tgattggaag cactgctttt taagtgtagt actttgggct atttcggctg 358441 ttagttcata agaattaaaa gctgatatgg ataagaaaga gaaaatgcgt tgcacatgtt 358501 cactgcttat aaagattagg ggaggtatga caatatggaa ataacttttt accctttaac 358561 ggatgcacaa aaacgaattt ggtacacaga aaaattttat cctcacacga gcatttcaaa 358621 tcttgcgggg attggtaagc tggtttcagc tgatgcgatt gattatgtgc ttgttgagca 358681 ggcgattcaa gagtttattc gcagaaatga cgccatgcgc cttcggttgc ggctagatga 358741 aaacggggag cctgttcaat atattagcga gtatcggcct gttgatataa aacatactga 358801 cactactgaa gatccgaatg cgatagagtt tatttcacaa tggagccggg aggaaacgaa 358861 gaaacctttg ccgctatacg attgtgattt gttccgtttt tccttgttca ccataaagga 358921 aaatgaagtg tggttttacg caaatgttca tcacgtgatt tctgatggta tctccatgaa 358981 tattctcggg aatgcgatca tgcacattta tttagaatta gccagcggct cagagacaaa 359041 agaaggaatc tcgcattcat ttatcgatca tgttttatct gaacaggaat atgctcaatc 359101 gaagcggttt gaaaaggaca aggcgttttg gaacaaacaa tttgaatcgg tgcctgaact 359161 tgtttccttg aaacggaatg catccgcagg gggaagttta gatgctgaga ggttctctaa 359221 agatgtgcct gaagcgcttc atcagcagat tctgtcgttt tgtgaggcga ataaagtcag 359281 tgttctttcg gtatttcaat cgctgctcgc cgcctatttg tacagggtca gcggccagaa 359341 tgatgttgtg acgggaacat ttatgggcaa ccggacaaat gcgaaagaga agcagatgct 359401 tggcatgttt gtttctacgg ttccgcttcg gacaaacatt gacggcgggc aggcgttttc 359461 agaatttgtc aaagaccgga tgaaggatct gatgaagaca cttcgccacc aaaagtatcc 359521 gtataatctc ctaatcaacg atttgcgtga aacaaagagc tctctgacca agctgttcac 359581 ggtttctctt gaatatcaag tgatgcagtg gcagaaagaa gaggatcttg cctttttgac 359641 tgagccgatt ttcagcggca gcggattaaa tgatgtctca attcatgtaa aggatcgatg 359701 ggatactggg aaactcacca tagattttga ttaccgcact gatttatttt cacgtgaaga 359761 aatcaacatg atttgtgagc gcatgattac catgctggag aacgcgttaa cgcatccaga 359821 acatacaatt gatgaattaa cactgatttc tgatgcggag aaagagaagc tgcttgcgag 359881 ggccggcggt aaatctgtga gctaccgtaa ggacatgacg ataccagagc tgttccaaga 359941 aaaggctgaa ctgctttctg atcatccagc ggttgtattt gaagatcgca cattgtccta 360001 tcgaacgtta catgagcaat ctgcacgcat cgccaatgtg ctgaaacaga aaggggttgg 360061 cccggacagt cctgtcgcgg ttttgattga acgctctgaa cggatgatta cagctatcat 360121 gggaatttta aaagccggcg gagcctatgt gccgattgat ccgggttttc ctgctgagcg 360181 cattcaatat attttggagg actgcggggc ggatttcatc ctgactgaat cgaaggttgc 360241 ggcgcctgaa gccgatgctg agctgattga cttagatcag gcgattgagg aaggtgcaga 360301 agaaagcctg aatgcagatg tgaacgctcg gaaccttgcc tacattattt acacatcggg 360361 aacaaccgga cgcccgaaag gcgttatgat cgagcatcgc caggttcatc atttggttga 360421 atctctgcag cagacgattt atcaaagcgg cagccaaacc ctgcggatgg cattgcttgc 360481 gccgttccac tttgatgcgt cagtgaagca gatcttcgcg tcgcttcttt tgggccaaac 360541 cctttatatc gtaccgaaga aaacagtgac gaacggggcc gcccttactg catattatcg 360601 gaagaacagc attgaggcga cggacggaac accggctcat ttgcaaatgc tggcagcagc 360661 aggcgatttt gaaggcctaa aactgaagca catgctgatc ggaggagaag gcctgtcatc 360721 tgttgttgcg gacaagctgc tgaagctgtt taaagaagcc ggcacagcgc cgcgtttgac 360781 taatgtgtac gggccgactg aaacgtgcgt tgacgcgtct gttcatccgg ttatccctga 360841 gaatgcagtt caatcagcgt atgtgccgat cgggaaagcg ctggggaata accgcttata 360901 tattttggat caaaaaggcc ggctgcagcc tgaaggcgtg gcgggtgagc tttatatcgc 360961 gggagacggt gtgggccgag gctatttaca tttgcctgaa ttaacggaag agaagttttt 361021 acaagatcca ttcgtgccgg gcgatcgcat gtaccggacc ggggacgtgg tgcgctggct 361081 tccagatgga acaatcgaat atttaggcag agaggatgac caggtcaaag tccgcggata 361141 ccggattgag cttggggaaa ttgaagccgt gattcagcag gcgccagacg ttgcaaaagc 361201 cgttgttttg gcacgccctg acgaacaggg aaatcttgag gtttgcgcat atgttgtgca 361261 gaagcctgga agcgaatttg cgccagccgg tttgagggag catgcggcca gacagcttcc 361321 tgactatatg gtgccggctt actttacaga agtgacagaa attccgctta caccaagcgg 361381 caaagtcgac cgccgcaagc tgtttgcact agaggtgaag gctgtcagcg gcactgccta 361441 tacagcgccg cgaaatgaga ctgaaaaagc aatcgcagcc atttggcagg acgtgctgaa 361501 cgttgagaag gcggggatct ttgacaattt ctttgaaact ggcggacatt cattaaaagc 361561 catgaccctt ttaacaaaga ttcataagga aacaggcatt gagattccgc ttcaattttt 361621 gtttgagcat ccgacgatta cggctcttgc agaggaagct gatcacagag aaagcaaagc 361681 ttttgcggtg attgaacctg ctgaaaaaca ggagcattac ccgctttcat tggcacagca 361741 gcgaacatat atcgtcagcc agttcgagga tgcgggagtc ggctataaca tgccagcagc 361801 agcaattctg gaagggcctt tagatattca aaagctggag cgcgcatttc agggattaat 361861 ccgacgccac gagtcattga gaacatcatt tgttcttgaa aacagcacgc cgagacagaa 361921 aattcacgat agcgttgatt tcaacatcga aatgattgaa agaggcggcc gctcagatga 361981 ggcaattatg gcttcattcg ttcggacatt tgatttggcg aaagctccgc tgttcagaat 362041 cggtttgctg gggcttgaag agaaccgtca tatgctgctg tttgacatgc accatttgat 362101 ttctgacggt gtatccattg gcattatgct ggaggagtta gcacgcattt ataaaggcga 362161 acagcttcct gatcttcgtc tccagtataa ggactacgct gtatggcaaa gcagacaggc 362221 tgctgaaggg tacaagaagg accaggctta ttggaaggaa gtctttgcag gcgagctccc 362281 ggtgcttcag cttctgtccg attacccaag accacctgtt caaagctttg aaggggatcg 362341 ggtgtcaatc aagctggatg cgggggtaaa ggatcgcctc aatcgtttgg ctgaacaaaa 362401 cggcgccact ttatatatgg tgatgctttc cgcttactat acgcttttgt caaagtatac 362461 ggggcaggat gacatcattg tcgggacacc gtcagcgggc agaaatcact ccgatacaga 362521 gggcattatc gggatgttcg tcaatacgct tgcgattcgc agtgaggtga agcagaatga 362581 gacgtttacc caattgatct cgcgtgtccg caaacgggtg ctggatgcct tttctcatca 362641 ggactatccg tttgagtggc ttgttgaaga tttgaacatc ccgcgtgatg ttagcaggca 362701 tccgctgttt gacacgatgt tcagccttca aaacgcgaca gagggcattc cggctgtcgg 362761 cgatctttcc ttgtctgttc aagagaccaa tttcaagatt gccaaatttg atttgacggt 362821 gcaggcgaga gaaaccgatg aaggcattga gattgatgtg gattacagca caaagctgtt 362881 taaacaaagc acggcagaca ggctgcttac gcattttgcg cgtttgcttg aagatgctgc 362941 ggctgatcca gagaagccga tttctgagta taagcttctt tctgaagagg aggctgcttc 363001 gcaaattcag cagtttaacc cgggcagaac accttatccg aaagataaaa caattgttca 363061 gctgtttgag gagcaagcgg cgaatacgcc agaccacact gcgcttcaat atgaaggcga 363121 atcactcact tatcgtgaac tgaatgaacg ggccaatcgt ttagcccgcg gcattctttc 363181 tcttggagct ggcgaaggca gaactgcggc tgtcttatgc gagcggtcaa tggatatgat 363241 tgtgtcgatc ttggcagtat taaaatcagg ttcggcttat gttccgatcg atccggaaca 363301 tccgattcag cggatgcagc atttcttccg tgacagcgga gcaaaggtgc ttctcactca 363361 gaggaaatta aaggctttgg cggaagaagc ggaatttaag ggcgttatcg tgctagccga 363421 tgaggaagaa agctatcatg ccgatgcgcg aaatctcgca ctgcctcttg attctgcagc 363481 aatggccaac ctgacgtata cttccggaac gactggaaca cctaagggga atatcgtgac 363541 acatgccaat attctccgca cggtgaagga aacgaattat ctcagcatta cagaacagga 363601 tacgattctc ggtctttcca attacgtgtt tgacgcgttt atgttcgata tgttcggctc 363661 tttgttaaac ggagccaagc tggtgctgat accgaaggaa accgttttgg acatggctcg 363721 cctgtcccgc gtcattgaac gggagaacat cagcattctc atgattacaa ccgctttgtt 363781 ccacttgctt gtggacttga atccggcatg cttgtcaacg cttcgcaaga ttatgtttgg 363841 cggggaacgg gcttcggttg agcatgtcag aaaagctttg caaacggttg gaaagggcaa 363901 gctccttcat atgtatggac cgtctgaaag cacggttttc gcgacgtatc atccggttga 363961 tgaattggag gagcacacgc tgtctgttcc gattggaaaa ccggtcagca atacggaagt 364021 atacattctt gaccgtacgg gacacgtgca gcctgccggg attgccggag agctttgcgt 364081 cagcggcgaa ggactcgtga aaggctatta caaccgtcca gaactgactg aggagaaatt 364141 tgttccccat ccgtttacat ccggcgaacg catgtataaa acgggagacc ttgcgagatg 364201 gctgccgaat ggcgacatcg aatttatcgg gcgaatcgac catcaggtga agattcgcgg 364261 acagcgcatc gagcttggag aaatcgaaca tcagctgcaa acccatgatc gtgttcagga 364321 aagtgttgtg cttgccgttg atcaaggagc gggagataaa ctgttgtgtg cttactatgt 364381 cggagaagga gacatctcat cacaagagat gagagagcat gctgcgaagg acttgccggc 364441 atatatggtt cctgcggtgt ttatccaaat ggacgagctg ccgctgacag ggaacggaaa 364501 aattgaccgg agagcgctgc cgattcctga tgccaacgtt tcaagaggtg tttcatatgt 364561 tgcgccacgc aatggaacgg aacaaaaagt cgcggacatt tgggcacagg tacttcaggc 364621 agaacaagtc ggcgcttatg accacttctt tgacattggc ggacattcat tagcaggcat 364681 gaagatgctt gccttggttc atcaggaact gggcgttgag ctgtcactca aggatctctt 364741 ccagtcaccg acggttgagg gcttggcaca ggtgattgcc tctgctgaaa aagggacagc 364801 cgcaagtatc agcccggcag agaaacaaga tacgtatcct gtttcttcac cgcaaaaacg 364861 gatgtacgtg cttcagcagc ttgaggatgc gcaaacgagc tataacatgc cggcggttct 364921 gcgcctgaca ggtgagcttg atgttgaaag gcttaacagc gtcatgcagc agttaatgca 364981 gcgtcatgaa gccttgagaa ccacgtttga aataaaagat ggagaaacgg tgcagcggat 365041 ctgggaagag gctgagtgcg agatagccta tttcgaagcc ccggaagaag agacagagcg 365101 gatcgtttct gagtttatta agcctttcaa aatcgaccaa cttccactgt tcagaatagg 365161 gcttatcaag cattcagaca ctgagcatgt gctgctgttc gatatgcatc atattatttc 365221 tgatggtgca tctgtcggtg tgctgattga ggagctttca aagctgtacg acggagaaac 365281 ccttgagccg ctccgtattc aatataagga ttatgccgtg tggcagcagc agttcattca 365341 gtctgagctt tacaagaagc aagaagagca ttggctgaag gagctggacg gagagctgcc 365401 ggtgctgacg cttccgactg attacagtcg gcctgccgtt caaacatttg agggagaccg 365461 cattgcattt tcattagaag caggcaaagc tgatgctctg cgcaggcttg caaaagaaac 365521 ggattccacg ctttacatgg tgcttctggc ttcatacagt gcgtttttat caaaaattag 365581 cgggcaagac gatatcatcg tcggttcacc tgtggccgga cgatctcaag cggacgtcag 365641 ccgcgtcatc ggaatgttcg tcaatacatt ggcgctgcgc acgtatccga agggtgaaaa 365701 gacgtttgct gactatctta acgaagtgaa agaaacggca ctcagcgctt ttgatgcgca 365761 ggattaccca cttgaggatt tgatcggaaa tgttcaggtt cagcgtgaca caagcagaaa 365821 tccgttattc gatgcagttt tttcaatgca aaatgcgaat ataaaggatt taacaatgaa 365881 agggattcag cttgagccgc atccgtttga acggaaaaca gccaagtttg acctcacgct 365941 gacggctgac gaaaccgacg gagggcttac attcgtactc gaatacaata cagctctgtt 366001 taagcaggaa acgattgaac gatggaagca atattggatg gagcttttag atgcagttac 366061 tgggaacccg aaccagccgc tttccagcct gtcactggtc accgagacag aaaagcaagc 366121 gcttcttgag gcatggaagg gcaaagcgct gcctgtgccg acagacaaaa cggttcatca 366181 gctattcgaa gagactgccc agcgccacaa agaccgcccg gctgtcacat acaacggcca 366241 gtcttggacg tacggcgagc tgaatgcgaa ggcaaaccgt ctcgcgcgga ttctgatgga 366301 ctgcggcatc agcccggatg accgcgtcgg cgttctcacg aagccgtcgc ttgaaatgtc 366361 cgccgcggtg ctcggcgtct tgaaagccgg agcggcgttt gtgccgattg atcctgacta 366421 tccggatcag cggattgagt atattttaca ggacagcggc gcgaagcttc tcttgaaaca 366481 ggaaggcatt tcagtgccgg acagctatac gggagatgtc attcttctcg acggaagccg 366541 cacgattcta agcctgccgc ttgatgaaaa cgacgaggaa aatccagaaa ccgctgtaac 366601 cgcggagaac ttggcgtaca tgatttacac gtctggaacg accggacagc cgaagggtgt 366661 catggtcgag caccatgcgc ttgtgaacct gtgcttctgg caccacgacg cgttcagcat 366721 gacagcggag gaccgcagtg cgaagtacgc gggctttggg ttcgacgctt ccatttggga 366781 gatgttcccg acctggacga tcggtgccga acttcacgtc attgaggaag cgatccgcct 366841 cgatatcgtc cgcctgaacg attattttga aacgaacggc gtaacgatca cgttcctgcc 366901 gacacagctt gcggaacagt tcatggagct tgagaacaca tcacttcgcg tattgcttac 366961 tggaggagac aagctgaagc gcgcagtgaa aaagccgtac acactcgtca ataactacgg 367021 gccgacagag aatacggtcg ttgccacaag cgcagaaatc catccggagg aaggctcgct 367081 ttccatcgga agggccattg ccaatacgag agtatacatt ctcggcgagg gcaatcaggt 367141 gcagccggaa ggcgtagccg gagagctttg cgtggcgggg cgcggactgg cacgcggcta 367201 tctgaatcga gaagacgaaa ccgcgaagcg gtttgtcgct gatccgtttg tgccgggtga 367261 gcgcatgtac cgcaccggcg atttggtgaa atggacgggc ggcggcatcg aatacatcgg 367321 ccggatcgac cagcaggtca aggtccgcgg ctaccggatc gagctctcag aaattgaagt 367381 ccagctcgcc cagctttctg aggtgcagga tgcggcggtg acagctgtca aagataaagg 367441 cggcaacaca gcgatcgcgg cgtatgtcac accggaatca gctgacatag aagcactgaa 367501 atcagcactg aaggaaaccc tgccggatta catgatcccg gcgttctggg tgacgctgaa 367561 cgagcttccg gttacggcaa acggcaaagt ggaccgcaaa gccttgcctg agccggacat 367621 cgaagcggga agcggagaat acaaagcgcc gacgaccgac atggaagagc tgcttgccgg 367681 catctggcag gacgtgcttg gaatgtctga agtcggtgtc accgacaatt tcttctcgct 367741 tggcggagat tccatcaaag gaattcaaat ggcgagccgc ttgaaccagc acggctggaa 367801 gctggaaatg aaagatctct tccagcaccc gacgatcgaa gagctcaccc agtacgtaga 367861 gcgtgccgaa ggcaaacagg cagaccaagg cccggtggag ggcgaagtca tcctgacgcc 367921 gatccagcgc tggttctttg aaaagaactt cacgaacaag caccactgga accaatctgt 367981 gatgcttcac gccaagaagg gctttgatcc tgaacgggtg gagaaaacat tgcaggcgct 368041 gatcgagcat catgacgcgc tccgcatggt ctatcgtgag ggacaggaag acgtcattca 368101 atacaacaga ggtcttgaag ctgcttcagc tcaattggag gtcatccaga ttgagggcca 368161 agctgcagat tacgaagacc gaatagagag agaagcggag cgtttgcaaa gcagcatcga 368221 cttgcaggaa ggcggcttgt taaaagcagg cttgttccaa gcggaagacg gagatcactt 368281 gcttcttgcc attcaccact tagtggttga cggcgtgtcg tggcggattt tactggagga 368341 tttcgccgcg gtatatacac agcttgagca aggcaatgaa ccggttctcc cgcagaaaac 368401 acattcattt gcagagtatg cagagagatt gcaagacttc gcgaactcca aagccttttt 368461 gaaagaaaaa gagtattgga gacagcttga agaacaagct gttgcggcaa agcttccgaa 368521 agaccgcgaa tctggtgatc agcgaatgaa acatacaaag acaattgaat tctcgctgac 368581 tgctgaagag acagaacagc tcaccacaaa ggtgcatgag gcatatcaca cagaaatgaa 368641 tgatattttg ctgacggcat tcggattggc aatgaaggag tggacgggtc aagatcgagt 368701 aagtgttcat ttagaggggc atggacgtga agaaatcata gaagacctga ccatttctcg 368761 cacagtcggc tggtttacaa gtatgtaccc aatggtgctc gatatgaagc atgcggatga 368821 tctgggctac cagctgaagc aaatgaaaga agatatcaga catgtgccga ataagggagt 368881 cggatacggc attctgcgct atctgacggc accggaacat aaagaagatg tggcgttctc 368941 gattcagccg gatgtcagct tcaactattt aggtcagttt gacgaaatgt cggatgcagg 369001 tttgtttacg agatcagagc tgccatcagg acagtcatta agccctgaaa cagaaaaacc 369061 gaatgcgctg gatgttgtcg gatatatcga aaacggaaaa ctgacgatgt cactggccta 369121 tcattctctt gaatttcatg aaaaaacagt acaaacattc agtgacagct ttaaagcgca 369181 tcttctcaga atcattgaac attgcctatc tcaagatggt acggaactga ccccgagtga 369241 tcttggtgac gacgatttga cgctggatga gctggataaa ttaatggaaa ttttctaata 369301 gaggtggcat atgagcaaaa aatcgattca aaaggtgtac gcactgacac caatgcagga 369361 gggaatgctg tatcatgcga tgcttgatcc gcattcttcc tcgtacttca cacaattaga 369421 gcttgggatt cacggcgctt ttgatcttga aatctttgag aaaagcgtca atgaactgat 369481 tcggtcatac gatattctcc gtacggtatt tgtgcatcag cagctgcaaa aaccgcgtca 369541 ggtcgtgtta gcggaacgca aaacaaaagt gcattatgag gatatcagtc atgcagacga 369601 aaaccgccag aaagagcaca ttgagcgtta caaacaagac gttcagcgcc aaggctttaa 369661 cctggcaaaa gacatattgt tcaaggtagc ggttttccgc cttgctgcag atcagctgta 369721 tcttgtctgg agcaatcatc atattatgat ggacggctgg agcatgggcg tcctcatgaa 369781 aagcctgttc caaaactatg aagcgctcag agcaggcagg acaccggcaa acggtcaggg 369841 caagccttat tccgattaca tcaagtggct tggaaaacag gacaatgaag aagcggagag 369901 ctactggagc gagcgcttgg cgggttttga acagccaagc gtgctcccgg gccgcctgcc 369961 tgtgaaaaaa gacgaatacg tcaataaaga atattcattt acatgggacg aaacactggt 370021 tgcccgtatt cagcaaaccg caaatctcca tcaagtgaca gggcctaacc tatttcaggc 370081 cgtttggggc attgttctca gcaaatacaa ctttacggat gatgtgatct tcggaacggt 370141 cgtctcggga cgaccgtctg aaatcaacgg aatcgaaacg atggcggggc tgtttatcaa 370201 caccattcca gtgcgggtga aagttgaacg agatgctgca ttcgctgata ttttcacagc 370261 tgttcagcag catgcagtag aggcagagcg ttacgattac gtgccgctct atgagattca 370321 aaaacgctca gctcttgatg gcaatctctt aaaccatctg gtcgcgtttg aaaattatcc 370381 gcttgatcaa gagcttgaaa acggcagcat ggaagaccgc ctcgggtttt cgattaaggt 370441 agaaagcgca tttgaacaaa cgagcttcga tttcaacctg attgtgtatc cgggcaaaac 370501 gtggaccgtc aaaattaaat ataacggagc cgcctttgat tccgctttta tcgaacggac 370561 agcggagcac cttacccgca tgatggaagc agctgtcgat cagccggccg cttttgtgcg 370621 tgagtacggg cttgtgggag acgaagagca gcggcaaatt gtcgaggtgt ttaacagcac 370681 gaaagccgaa ctccctgaag gaatggctgt tcaccaagtg tttgaagagc aagcgaaacg 370741 gacgccggcg agcaccgccg tcgtatatga aggaaccaag ctgacgtacc gcgagctgaa 370801 tgcagcggct aaccgtctgg cgagaaagct tgtcgaacat gggcttcaaa aaggggaaac 370861 agcagcgatt atgaacgacc gctcagtaga aaccgttgtc ggcatgctgg ctgttttaaa 370921 agcaggcgcc gcatatgtgc cgcttgatcc agcgcttcct ggggatcgtc ttcgtttcat 370981 ggcagaggac agctccgttc gaatggtttt gatcggaaat tcttatacag ggcaggcaca 371041 tcagctgcaa gtgccggttc ttacactgga cataggcttt gaagagagtg aagcggctga 371101 caatctcaac ctgccatccg ccccgtctga tttggcgtac atcatgtaca catccggttc 371161 aacgggcaaa ccgaaaggcg tcatgatcga acataaaagc attctgcgcc tcgtcaaaaa 371221 tgccgggtac gttcctgtta ctgaagaaga ccgcatggcg caaacgggag ctgtcagctt 371281 tgatgccgga acgtttgagg tattcggcgc actgctgaat ggcgcagcac tttatccggt 371341 caaaaaagag acactgcttg atgcgaaaca atttgctgca ttcctgcgtg agcaaagcat 371401 cacaactatg tggctgacat cacctttatt caaccagctt gctgcaaagg atgcgggtat 371461 gttcggcaca ctgcgccatt taatcatcgg cggagatgcc cttgtcccgc atattgtcag 371521 caaagtaaaa caggcatcgc cgtcgctttc attgtggaac ggatacggcc cgacagaaaa 371581 cacgacgttt tcaaccagtt ttctgatcga ccgcgagtat ggcggctcta tcccaatcgg 371641 gaagccgatc ggaaattcca ctgcctatat tatggatgag cagcaatgcc tgcagccaat 371701 cggcgcgcct ggtgagcttt gcgtaggcgg aatcggtgta gcgcgtgggt atgtcaatct 371761 ccctgagctg acggagaagc aatttctgga agacccgttc agaccgggtg agagaattta 371821 ccgcactggt gacttggcaa gatggctgcc ggacggcaat atcgaatttt taggcagaat 371881 cgacaaccaa gtgaaggtgc gcggcttccg aattgagctt ggcgaaattg aaacaaaact 371941 gaacatggct gagcatgtga cagaagccgc ggtgatcata cgcaagaaca aagcagacga 372001 aaatgaaatt tgcgcgtact tcacggcgga tcgtgaagtg gctgtgagtg agctgagaaa 372061 aacactgtct cagtctttgc ctgactatat ggtccctgcc cacctgattc aaatggacag 372121 cctgccgctc acgccaaacg ggaaaatcaa caaaaaggaa ctgcctgcac cgcaatcaga 372181 agccgtgcag ccggaatacg cagcaccaaa aacagagagt gaaaagaaat tagcggagat 372241 ctgggaagga atactcggcg tcaaagcagg cgttaccgat aacttcttta tgatcggcgg 372301 ccattctttg aaagcgatga tgatgacggc gaaaattcaa gagcattttc ataaggaagt 372361 tccgataaaa gtgctttttg aaaagccgac tattcaagaa ctggcactgt atttggaaga 372421 gaacgaaagc aaggaggagc agacgtttga accgatcagg caagcatctt atcagcagca 372481 ttatcctgta tccccggccc agcggagaat gtatatcctc aatcagcttg gacaagcaaa 372541 cacaagctac aacgtccccg ctgtacttct gctggaggga gaagtagata aagaccggct 372601 tgaaaacgcg attcagcaat taatcaaccg gcacgaaatc ctccgtacat cgtttgacat 372661 gatcgacgga gaggttgtgc aaaccgttca taaaaacata tcgttccagc tggaggctgc 372721 caagggacgg gaagaagacg cggaagagat aatcaaagca tttgttcagc cgtttgaatt 372781 aaaccgcgcg ccgctcgtcc gttcgaagct tgtccagctg gaagaaaaac gccacctgct 372841 gctcattgat atgcatcata ttattactga cggaagttca acaggcattc taatcggtga 372901 tcttgccaaa atatatcaag gcgcagatct ggaactgcca caaattcact ataaagatta 372961 cgcagtttgg cacaaagaac aaactaatta tcaaaaagat gaggaatact ggctcgatgt 373021 ctttaaaggc gaactgccaa tactggatct tcccgcggat ttcgagcggc cagctgaacg 373081 gagctttgcg ggagagcgcg tgatgtttgg gcttgataag caaatcacgg ctcaaatcaa 373141 atcgctcatg gcagaaacag atacgacaat gtacatgttt ttgctggcgg cgttcaatgt 373201 actcctttcc aagtacgcgt cacaggatga tatcattgtc ggctcgccga cagctggcag 373261 aacacatcct gatctgcaag gtgtgccggg tatgtttgtc aacacggtgg cactcagaac 373321 ggcaccagcg ggagataaaa ccttcgcgca attccttgaa gaggtcaaaa cagccagcct 373381 tcaagcattc gagcaccaga gctatccgct tgaggagctg attgaaaagc ttccgcttac 373441 aagggataca agcagaagtc cgctgttcag cgtgatgttc aacatgcaga atatggagat 373501 tccttcatta agattaggag atttgaagat ttcctcgtat tccatgcttc atcatgttgc 373561 gaaatttgat ctttccttgg aagcggtcga gcgtgaagag gatatcggcc taagctttga 373621 ctatgcgact gccttgttta aggacgagac gatccgccgc tggagccgcc actttgtcaa 373681 tatcatcaaa gcggccgcgg ctaatccgaa cgttcggctg tctgatgtag atctgctttc 373741 atctgcagaa acggctgctt tgctagaaga aagacatatg actcaaatta ccgaagcaac 373801 ctttgcagca ctttttgaaa aacaggccca gcaaacacct gaccattctg cggtgaaggc 373861 tggcggaaat ctgttgacct atcgcgagct tgatgaacag gcgaaccagc tggcgcatca 373921 tcttcgtgcc caaggggcag gaaatgaaga catcgtcgcg attgttatgg accggtcagc 373981 tgaagtcatg gtatccattc tcggtgtcat gaaggcgggg gcagctttcc ttccgattga 374041 tcctgataca cctgaagaac gaatccgtta ttcattagag gacagcggag caaaatttgc 374101 ggtcgtgaat gaaagaaaca tgacggctat tgggcaatat gaagggataa ttgtcagcct 374161 tgatgacggt aaatggagaa atgaaagcaa ggagcgccca tcatccattt ccgggtctcg 374221 caatcttgca tacgtcattt atacgtccgg tacgaccgga aagccaaagg gcgtgcagat 374281 tgagcatcgt aatctgacaa actatgtctc ttggtttagt gaagaggcgg gcctgacgga 374341 aaatgataag actgtattgc tttcatctta cgcatttgac cttggctata cgagcatgtt 374401 ccctgtactt ctgggcgggg gcgagctcca tatcgtccag aaggaaacct atacggcgcc 374461 ggatgaaata gcgcactata tcaaggagca tgggatcact tatatcaagc tgacaccgtc 374521 tctgttccat acaatagtga acaccgccag ttttgcaaaa gatgcgaact ttgaatcctt 374581 gcgcttgatc gtcttgggag gagaaaaaat catcccgact gatgttatcg ccttccgtaa 374641 gatgtatgga cataccgaat ttatcaatca ctacggcccg acagaagcaa cgatcggcgc 374701 catcgccggg cgggttgatc tgtatgagcc ggatgcattt gcgaaacgcc cgacaatcgg 374761 acgcccgatt gcgaatgccg gtgcgcttgt cttaaatgaa gcattgaagc ttgtgccgcc 374821 tggagcgagc ggacagctct atatcacggg acaggggctc gcgagagggt atctcaacag 374881 gcctcagctg acagccgaga gatttgtaga aaatccatat tcgccgggaa gcctcatgta 374941 caaaaccgga gatgtcgtac gaagactttc tgacggtacg cttgcattta tcggccgggc 375001 tgatgatcag gtgaaaatcc gaggctaccg cattgagccg aaagaaattg aaacggtcat 375061 gctcagcctc agcggaattc aagaagcggt tgtactagcg gtttccgagg gcggtcttca 375121 agagctttgc gcgtattata cgtcggatca agatattgaa aaagcagagc tccggtacca 375181 gctttcccta acactgccgt ctcatatgat tcctgctttc tttgtgcagg ttgacgcgat 375241 tccgctgacg gcaaacggaa aaaccgacag aaacgctctg ccgaagccta acgcggcaca 375301 atccggaggc aaggccttgg ccgcaccgga gacagcgctt gaagaaagtt tatgccgcat 375361 ttggcagaaa acgcttggca tagaagccat cggcattgat gacaattttt tcgatttagg 375421 cggccattca ttaaaaggga tgatgctgat tgccaacatt caggcggaat tggagaaaag 375481 cgtaccgctt aaagcactgt tcgagcagcc gacagttcgc cagctggcgg cttatatgga 375541 ggcgtctgct gtttcaggcg gccatcaagt actcaaaccg gctgacaagc aggatatgta 375601 tccattgtca tccgcacaga aacgaatgta cgtgctcaat cagcttgacc gccagacgat 375661 aagctacaac atgccatctg ttcttctaat ggaaggagag cttgatattt cgcgcctgcg 375721 cgactcactc aatcagcttg tgaaccgtca cgaatcattg cggacgtcat ttatggaagc 375781 taatggtgag cctgttcagc gcatcattga gaaggcggag gttgatcttc atgtgtttga 375841 agccaaagaa gacgaagcgg accaaaagat taaggaattt atccggccat tcgacttaaa 375901 cgacgcaccg ctcattcgcg cagctttgct tcgaatagaa gcgaaaaaac atttgctgct 375961 tttagatatg catcatatca tcgcagacgg cgtctcaaga ggcatctttg taaaagaatt 376021 ggcgctgctt tacaaaggag agcagcttcc ggagccgacg cttcattata aagatttcgc 376081 cgtttggcaa aatgaagctg agcaaaaaga acggatgaag gagcatgagg cgtactggat 376141 gtcagttctt tcaggcgagc tgccagagct tgatctcccg ctcgattatg cccgtccgcc 376201 tgtgcaaagc tttaaaggag atacgatccg tttccgtacg ggaagtgaga cggcaaaggc 376261 ggtagaaaaa ctgcttgccg aaaccggaac gaccttgcac atggtgctcc atgctgtttt 376321 ccacgtcttt ttaagcaaaa tttccggaca gcgggatatc gtcatcggct ccgttactgc 376381 cggccggacg aatgctgatg ttcaggacat gccgggaatg ttcgtcaata cacttgccct 376441 gagaatggaa gcgaaagaac agcaaacatt tgcggagctt ttggagctag caaagcagac 376501 gaacctgtca gcccttgagc atcaggagta tccgtttgaa gatctggtta atcagcttga 376561 tctccctcgg gatatgagcc gaaacccatt gtttaatgtg atggtgacga cagaaaaccc 376621 tgataaagaa cagcttacat tgcaaaatct gagcatttca ccttatgagg ctcatcaggg 376681 aacttctaag tttgatctga cactgggcgg atttactgat gaaaatggca ttggcttgca 376741 gctcgaatat gcgacagatc tgttcgcaaa agaaacagct gaaaaatgga gcgaatacgt 376801 tctgcggcta ctaaaggctg ttgcggataa cccgaaccag ccgctttcca gtctgttact 376861 ggtcaccgag acagaaaagc aagcgcttct tgaggcatgg aagggcaaag cgctgcctgt 376921 gccgacagac aaaacggttc atcagctatt cgaagagact gtccagcgcc acaaagaccg 376981 cccggctgtc acatacaacg gccaatcttg gacgtacggc gagctgaacg cgaaggcaaa 377041 ccgcctcgcc cggattctga tggactgcgg catcagcccg gatgaccgcg tcggcgttct 377101 cacgaagccg tcgcttgaaa tgtccgccgc ggtgctcggc gtcttgaaag ccggagcggc 377161 gtttgtgccg attgatcctg actacccgga tcagcggatt gagtatattt tacaggacag 377221 cggcgcgaag cttctcttga aacaggaagg catttcagtg ccggacagct atacgggaga 377281 tgtcattctt ctcgacggaa gccgcacgat tctaagcctg ccgcttgatg aaaacgacga 377341 gggaaatcca gaaaccgctg taaccgcgga gaacttggcg tacatgattt acacgtctgg 377401 aacgaccgga cagccgaagg gtgtcatggt cgagcaccat gcgcttgtga acctgtgctt 377461 ctggcaccac gacgcgttca gcatgacagc ggaggaccgc agtgcgaagt acgcgggctt 377521 cgggttcgac gcttccattt gggagatgtt cccgacctgg acgatcggcg ctgaacttca 377581 cgtcattgat gaagcgatcc gcctcgatat cgtccgcctg aacgattatt ttgaaacgaa 377641 cggcgtaacg atcacgttcc tgccgacaca gcttgcggaa cagttcatgg agcttgagaa 377701 cacatcactt cgcgtcctct tgaccggagg agacaagctg aagcgggcag tgaaaaagcc 377761 gtacacactc gtcaacaact acgggccgac agaaaatacg gtcgttgcca caagcgcaga 377821 aatccatccg gaggaaggct cgctttccat cggacgggcc attgccaata cgagagtata 377881 cattctcggc gagggcaatc aggtgcagcc ggaaggcgta gccggagagc tttgcgtggc 377941 ggggcgcgga ctggcacgag gctatctgaa tcgagaagac gaaaccgcga agcggtttgt 378001 cgctgatccg tttgtgccgg gtgaacgcat gtaccgcacc ggcgacttgg tgaagtgggt 378061 gaacggcggc atcgaataca tcggccggat cgaccagcag gtcaaggtcc gcggctaccg 378121 gatcgagctc tcagaaattg aagtccagct cgcccagctt tctgaggtgc aggatgcggc 378181 ggtgacagct gtcaaagata aaggcggcaa tacagcgatc gcggcgtatg tcacaccgga 378241 aacagctgac atagaagcac taaaatcaac actaaaggaa accctgccgg attacatgat 378301 cccggcgttc tgggtgacgc tgaacgagct tccggttacg gcaaacggca aagtcgaccg 378361 caaagccttg cctgagccgg acatcgaagc gggaagcgga gaatacaaag cgccgacgac 378421 cgacatggaa gagctgcttg ccggcatctg gcaggacgtg cttggaatgt ctgaagtcgg 378481 tgtcaccgac aatttcttct cgcttggcgg agattccatc aaaggaattc aaatggcgag 378541 ccgcttgaat cagcacggct ggaagctgga aatgaaagat ctcttccagc atccgacgat 378601 cgaagagctc acccagtacg tagagcgtgc cgaaggcaaa caggcagacc aaggcccggt 378661 ggagggcgaa gtcatcctga cgccgatcca gcgctggttc tttgaaaaga acttcacgaa 378721 caagcaccac tggaaccaat cggtgatgct tcacgccaaa aagggctttg atcctgaacg 378781 ggtggagaaa acattgcagg cgctgatcga gcatcatgac gcgctccgca tggtctaccg 378841 cgaggaaaac ggggacatcg ttcaggtgta taaaccgatc ggtgagagca aggtcagctt 378901 cgaaatcgtg gatctgtacg gctccgatga agagatgctg agaagccaga ttaagcttct 378961 cgcgaacaag ctgcaaagca gtctcgatct gcgaaacggg ccgcttttaa aggcggagca 379021 atatcgcaca gaagctgggg atcacctgct cattgctgta caccatctcg tggtcgacgg 379081 tgtgtcatgg cggattttgc ttgaagactt tgcttcaggc tacatgcagg ctgagaaaga 379141 agagagcctt gtcttcccgc aaaaaacaaa ctccttcaag gattgggcgg aagaactggc 379201 ggcattcagc caatcagcgc atcttttaca gcaggctgaa tactggtcgc aaattgccgc 379261 tgaacaggtt tctcctttac ctaaggattg tgaaacagag cagcggatcg tcaaggatac 379321 atcatctgtc ctatgtgaat taacggcaga agacactaag catcttttaa cagatgttca 379381 tcagccatat ggaactgaaa tcaacgatat tcttctcagc gcgctcggtt tgacaatgaa 379441 agaatggaca aagggggcca aaattggcat taaccttgag ggacacggcc gggaggacat 379501 tatcccgaat gtgaatatct ccagaacggt cggctggttt acggcacaat accctgttgt 379561 gctcgacata tctgacgcag atgcctcagc tgtgatcaaa acagtcaaag aaaacctgcg 379621 ccgcattccg gacaaaggtg ttggctacgg cattcttcgt tatttcacag aaacagcgga 379681 aacaaagggc ttcacaccgg agatcagctt caactatttg ggccaattcg acagtgaagt 379741 caaaaccgat ttctttgaac cgtccgcttt cgatatgggg cgccaagtaa gcggagaatc 379801 agaggcgctg tacgcattaa gcttcagcgg catgatcaga aacggccggt ttgtgctttc 379861 ctgctcctac aatgagaagg agtttgaaag agctacagtc gaggagcaaa tggaacggtt 379921 taaagaaaac ctcctgatgc taatccgcca ttgcacggaa aaagaagaca aggaattcac 379981 accaagcgac ttcagcgccg aagaccttga aatggacgag atgggagata tctttgacat 380041 gcttgaggag aatttaaaat aaaacgcaag ggaattacag aaggcgggag cgaaacatat 380101 gagtcaattt agcaaggatc aggttcaaga tatgtattac ctatcgccga tgcaggaagg 380161 gatgcttttt catgccatcc tgaatcccgg ccaaagcttt taccttgaac aaatcacgat 380221 gaaagtaaaa ggcagcttga atatcaaatg tcttgaagaa agcatgaatg tgatcatgga 380281 ccggtacgat gtatttcgta ccgtgttcat tcacgaaaaa gtaaaaaggc ctgtccaagt 380341 cgtattgaaa aaacggcagt tccatataga agaaatcgat ctgacacact taacgggcag 380401 cgagcaaaca gccaaaatca atgagtacaa agaacaggat aagatcaggg gttttgattt 380461 gacgcgggat attccgatgc gggcagccat tttcaagaaa gctgaagaaa gctttgaatg 380521 ggtgtggagc taccaccaca ttattttgga cggatggtgc ttcggcatcg tcgtacagga 380581 tctatttaag gtatacaatg ctctgcgcga acaaaagccg tacagcctgc cgcccgtcaa 380641 accgtataaa gactacatca agtggcttga aaagcaggat aaacaagcat cactgcgtta 380701 ctggcgcgaa tatttagagg gctttgaagg acaaacgacg tttgcggagc aaagaaagaa 380761 acaaaaggac ggctatgagc cgaaagagct gctcttttca ctgtcggagg cggaaacaaa 380821 ggcctttacc gagcttgcaa aatcgcagca taccactttg agtacggcgc tgcaggcagt 380881 ctggagcgta ttgatcagcc gctatcagca gtctggcgat ttggccttcg gtacagttgt 380941 ttcagggcgt cccgcggaaa tcaaaggcgt tgaacatatg gtcgggctgt ttatcaacgt 381001 tgtcccgaga cgtgtgaagc tgtctgaggg tatcacattt aacggcttgc tcaagcggct 381061 gcaggagcaa tcgctgcagt ccgagccgca tcaatatgtg ccgctttatg acatccaaag 381121 ccaggccgat cagccgaaac tgattgacca catcattgtt tttgagaact atccgcttca 381181 ggatgcgaaa aatgaagaaa gcagtgaaaa cggctttgat atggtggatg ttcatgtttt 381241 tgagaagtcg aattatgatc tcaacctgat ggcttccccg ggagatgaga tgctgattaa 381301 gcttgcctat aatgagaatg tgtttgatga ggcgtttatc ctgcgcttga aatctcagct 381361 tcttacagca attcagcagc tcatccagaa tcctgatcag cctgtcagca cgatcaacct 381421 cgttgacgac agggagagag aatttttgct aaccggctta aacccgccgg ctcaagctca 381481 tgaaacaaag cctctgacgt attggttcaa ggaagcagtg aacgccaatc cggatgcacc 381541 ggcgcttacg tattccggcc agaccctgtc ttatcgcgaa ttagatgagg aagcgaaccg 381601 cattgcacgc cggctgcaaa aacacggtgc gggcaaaggc tctgttgtag cgctgtacac 381661 gaagcgctca cttgaactgg tgatcggcat tctcggtgta ttaaaggcgg gagcagccta 381721 tctgccggtt gatccgaagc tgccagagga ccgaatctcg tatatgctgg ctgacagtgc 381781 ggcagcctgt cttctgacgc atcaggagat gaaagaacaa gcggctgagc tgccgtatac 381841 aggcacaacg ctcttcattg atgatcaaac acggtttgaa gaacaggcaa gcgatcctgc 381901 aaccgcgatt gatcctaatg atccggcata tatcatgtac acgtccggca caaccggaaa 381961 gccaaagggc aatatcacca ctcatgccaa tattcaagga ttggtcaagc atgtagacta 382021 catggcattt tctgatcagg atacgttctt gtctgtttcg aattacgcct ttgatgcatt 382081 tacctttgat ttctatgctt ctatgctgaa tgcggcacgg ctcattatcg cagatgaaca 382141 tacgctgctt gatacagaac ggctcacaga tctgatcctg caagagaatg tcaatgtcat 382201 gtttgcgaca accgcactat ttaatcttct cacagatgcg ggagaggatt ggatgaaggg 382261 gcttcgctgt atattattcg gcggagagcg cgcgtcagtg cctcatgtca gaaaagcgct 382321 gcggatcatg gggccgggca agctgattaa ctgctacggg ccgactgagg gaacagtgtt 382381 tgcgacagct cacgtcgtgc atgatctgcc ggattccatc tcctcattgc cgatcggaaa 382441 gccgatcagc aatgccagtg tttatattct gaatgagcaa agccagctcc agccattcgg 382501 ggcggtcggt gaactgtgca tcagcggaat gggcgtgtca aaagggtatg taaatcgtgc 382561 tgacctcacg aaggaaaagt ttatcgagaa cccgttcaag ccgggagaaa cgctttaccg 382621 tacaggggat ttagcgcgct ggctgccgga tggaacgatt gaatacgccg gccgtattga 382681 cgaccaggtc aaaatacgcg gacaccggat tgagcttgaa gaaatcgaaa agcagctgca 382741 ggaataccca ggtgtgaaag atgcggtcgt tgtggcggac cgccatgagt ctggcgatgc 382801 atcaatcaat gcctaccttg tgaaccgaac gcagctttca gctgaagacg tgaaggcgca 382861 cctgaaaaaa cagcttcctg cttacatggt gccgcaaacc tttaccttct tggatgagct 382921 tcctttaacg acgaacggga aagtcaataa acggctgctc ccaaaacctg atcaggatca 382981 gctggcggaa gaatggattg gaccgcggaa cgagatggaa gaaacaatcg cacaaatatg 383041 gtctgaggtt ctcggcagaa agcaaattgg cattcatgac gatttctttg cgctcggagg 383101 gcattccttg aaggccatga ccgccgcgtc ccgcatcaag aaagagctcg ggattgatct 383161 tccagtgaag cttttgtttg aagcgccgac gatcgccggc atttcagcgt atttgaaaaa 383221 cgggggctct gatggcttgc aggatgtaac gataatgaat caggatcagg agcagatcat 383281 tttcgcattt ccgccggttc tgggctatgg ccttatgtac caaaatctgt ccagccgctt 383341 gccgtcatac aagctatgcg cctttgattt tattgaggag gaagaccggc ttgaccgcta 383401 tgcggatttg atccagaagc tgcagccgga agggccttta acattgtttg gatattcagc 383461 gggatgcagc ctggcgtttg aagctgcgaa aaagcttgag gaacaaggcc gtattgttca 383521 gcggatcatc atggtggatt cctataaaaa acaaggtgtc agtgatctgg acggacgcac 383581 ggttgaaagt gatgtcgaag cgttgatgaa tgtcaatcgg gacaatgaag cgctcaacag 383641 cgaagccgtc aaacacggcc tcaagcaaaa aacacatgcc ttttactcat actacgtcaa 383701 cctgatcagc acaggccagg tgaaagcaga tattgatctg ttgacttccg gcgctgattt 383761 tgacatgccg gaatggcttg catcatggga agaagctaca acaggtgttt accgtgtgaa 383821 aagaggcttc ggaacacacg cagaaatgct gcagggcgaa acgctagata ggaatgcgga 383881 gattttgctc gaatttctta atacacaaac cgtaacggtt tcataaatga agtgatgaaa 383941 ggaggagaca gccaatgagc caactcttca aatcatttga tgcgtcggaa aaaacacagc 384001 tcatctgttt tccgtttgcc ggcggctatt cggcgtcgtt tcgccctctc catgcttttt 384061 tgcaggggga gtgcgagatg ctcgctgccg agccgccggg acacggcacg aatcaaacgt 384121 cagccattga ggatctcgaa gagctgacgg atttgtacaa gcaagaactg aaccttcgcc 384181 ctgatcggcc gtttgtgctg ttcggacaca gtatgggcgg aatgatcacc ttcaggctgg 384241 cgcaaaagct tgagcgtgaa ggcatctttc cgcaggcggt tatcatttct gcaatccagc 384301 cgcctcatat tcagcggaag aaagtgtccc acctgcctga tgatcagttt ctcgatcata 384361 ttatccaatt aggcggaatg cccgcagagc ttgttgaaaa taaggaggtc atgtcctttt 384421 tcctgccttc tttccgatca gattaccggg ctcttgaaca atttgagctt tacgatctgg 384481 cccagatcca gtcgcctgtt catgtcttta acgggcttga tgataaaaaa tgcatacgag 384541 atgcggaagg gtggaagaag tgggcaaaag acatcacatt ccatcaattt gacggcgggc 384601 acatgttcct gctgtcacaa acggaagaag tcgcagaacg gatttttgcg atcttgaatc 384661 agcatccgat cattcaaccg tgatcaaaag cggacagctt cggctgttcc gctttttttg 384721 tgttgaatgc caatttctgc atggtataat agtcgaaata ctcaaataaa ggcaggtcga 384781 aacatgcgca cgtctcccag gatgaaatgg tttgtattgc tgtttacgtt tgttttcgcc 384841 atcggaatga actcattcag aaattccttt caatttttta tgctgccaat ggcagacgcc 384901 ttccatgccg acaggtcgct gatttcggtt tctgtcagca tttttatgat cacaaccggc 384961 atcgtccagt tttttgtcgg tttttttatc gaccgtttca gtgtcagaaa aattatggcg 385021 ctgggagctg tttgcatcag cgcaagcttt ttggtgcttc cttattcacc gaatgttcat 385081 gtgttttccg ccatttacgg tgtgcttggc ggaatcgggt attcctgcgc ggtcggcgtg 385141 acgacccagt atttcatcag ctgttggttt gacacacaca aaggtctggc gcttgctatt 385201 ttgaccaatg ccaactctgc gggcctgctg cttctctcgc ccatttgggc tgcggctccg 385261 tatcatgccg gctggcagag cacctatacc attttgggaa tcgtcatggc ggctgttctg 385321 ctgccgctcc tcgtctttgg gatgaagcac ccgccacatg cgcaagcgga aactgtgaaa 385381 aaatcttatg attggcgagg gttttggaac gtgatgaagc aatcccgcct cattcatatc 385441 ctgtacttcg gcgtgtttac ttgcggattt acaatgggaa ttattgatgc tcacctcgtc 385501 ccgatactga aggatgcgca tgtctctcat gtcaacggaa tgatggccgc gttcggggca 385561 tttatcatca ttggcggatt attggcgggc tggctgtcag atctcctcgg cagcagaagc 385621 gtcatgctat ccatcttatt tttcattcgg ctgctcagcc tcatttgcct gctcattccc 385681 attctcggaa ttcatcacag cgacctttgg tacttcgggt ttatcctgtt attcgggctc 385741 agttacacag gcgtgatccc gctgaccgcg gcgtcaattt cggaaagcta tcaaacagga 385801 ttgatcggat cgctgttagg catcaatttc tttatccatc aggttgccgg agctctcagc 385861 gtgtatgcgg gcggtttgtt ttttgacatg actcatggtt atttactgat tgtcgctgtg 385921 tgcatcgtgt ttgtgggttt atcggctgta atagagctgg tgccgttttt agataaacag 385981 aaggcaaaag aaacccacca ttcaatataa aaggatcagc actgtcaatg ctgatccttt 386041 ttaaatttga gtttttttgt ttcggtattt ttaaggataa tctccttgaa tctgttcatc 386101 tcctcttcgg agtgaaaaaa atgtttgggg atcgcaatat attggccact tgatgtattg 386161 accctgaaga tatttttata ttcgaaaaca gctgtaattt catcccaatt gaaaatgagg 386221 tcatattttt tagaacatat acgaattcct tcttggttca gagtatatgt tcttttggat 386281 ttcatccgtt cgttcttctt gtatgctctg gaaaacttca catatagaag aaggaggagc 386341 agcagtgtaa acagaacgga catcacgata atcaacatac tgttcataaa caagttaagc 386401 gcgtcacttc cataaacgat acggggccat ccgttaatga agttaactgc agcaaatatg 386461 gcgcaaaaca atagaaagta aaagcatgat atttttgcga tttgataaaa aaagatttct 386521 cttacatcct taaaagtgat ttctcctgga agattgatac tttcactagc atattgaatc 386581 atacggtaaa cctacacctc taaccatgtt tttcctttta gtctagcata atttctcatt 386641 tttttgcagg cataccaggg cgctttgttt ttttctccag attgatattg ctccccacca 386701 cgccaatcat aatacaaaca gccccggcaa gatgatacca ggccaggctt tcgttgagaa 386761 tcacaaatcc tgcaatcatc gtcacaatgg tagatacatg attaaaagcg ctcattttaa 386821 acgcctcaat tcgcgacagc gtatagttag acagaaatga agtgacaagt gaagacagca 386881 cgcccaaata cacaatggcg agaacgaagc cgggctcccg gaacggcaga aaataagtgc 386941 cgactgttcc cgccgctccg tgacgcacaa gggcgatggc gttgaagacg acaaagccga 387001 tggctgacat gatgtaggtg agctcggtca gcttgaaccg ctgcgtcatt tttctggcag 387061 cagtattgta catcgctgaa gacaaagcgg acaataggat cagcaaagac ccttttaagc 387121 tggctgattc cacgtcaacg cctttcatca caaaaataaa catgacgccg gcaacggata 387181 aaaccgtgaa ccccttttgc gtccacgttg ggcgttcctt taaaacataa gcggcaaaga 387241 ccatcgtgaa aatcggaatg gctgcctgaa taattcccgc ttcagaggag gacgagtaca 387301 caaggccgaa tgcctgaaag ctgaaaaata acgcgggata cagcagggcg agcggcaaaa 387361 tgtcaatgac gtcctttacg cggattgata gctttaccca gccgaataag atcggtacag 387421 tggccgcagc aaacgcaatg gtgaaccgat gcgccaaaat atcaaacggc tctgctgttt 387481 gcagtgcgat ttttacgaat agaaaggata aaccgataat gaacgaatat aaaatagccg 387541 ctatataagc gggggtttgc tgatgtttaa ccataatggg aagggctcct ttacctgaat 387601 tgcagcgccg gtcgctccct ttattgtatg gccgcggtca gaacggtaca atgagaaaaa 387661 caatgaactg taccggtaca aaacaggggg agaaggcatg gagaaatata tgagtctatt 387721 aacgaggata gaggagatga tgcaaagcac ctcatatcaa gaaggagaca ggcttccatc 387781 tatccgtcag ctgtccgccc gctaccaagt cagcaaaagc acagtgatcc gcgcgctgca 387841 ggagctggaa aagcgccacc ttatctattc tgttccgaaa agcggctatt atattgtgaa 387901 aaagtcaggg aaatcaaaaa gcgggcagcc tggccccatc gactttgcca catctgcgcc 387961 ggatcccgat gtgtttccgt atcttgattt tcagcactgc atcaacaaag cgattgatac 388021 atacaaaaac gatttgttta tttatgggac gccaaagggg cttccatcac tcatccgcgt 388081 actccgaaag ctcttggcca ctcaacaggt atttgcggat gaacggcata ttttcattac 388141 atcaggtgtc cagcaggcgt tatccttgct ttgtgccatg ccgttcccaa atgggaaaga 388201 gaagatcgcc attgaacagc cgggctacca tttgatggtc gaacagcttg agacacttgg 388261 gattcccgcc atcggggtga aacgaacgga agaagggctt gatatagcca aggttgagcg 388321 gttatttcaa acagaatcga ttaaattttt ttatacgatg ccgcgcttcc ataacccgct 388381 tgggtgctca ttgtcagagc gtgataaaca ggagcttgtg agactggcag aagcgtatga 388441 tgtctatctc gttgaggatg attacctcgg tgatctggag gaaaataaaa aggcagatcc 388501 gctgtacgca tatgatctgt cctcacatgt catctatttg aaaagcttct cgaaaatgat 388561 gttccccggc ctccgcgtgg gggcggctgt tttgcccgaa gcgctgactg acacgttcta 388621 tgcgtacaaa aagctgaacg acatcgactg ttcgatgatt tctcaagcgg cattggagat 388681 ttacctgaaa agcggtatgt acggcaggca taaggagaaa atcagagatt cttataaaga 388741 gcggtcgctg aggctacatc aagccattcg aactcacagg cagctgggaa gcggacgctt 388801 tacgttctcc agcgggcagg caccctgtat gcacacccat ctggtgcttc ctcaggatct 388861 gcccgcctca agagtgattc atagactgga aaaacaaggg gttctccttg aggcgataga 388921 ccgtcattat ttatcagatt atccgaaaga aaatctatta aaaatcaata tttccaatgt 388981 gaaaacggaa gatattgagc gcggtgtcaa gctgttgatg agccatttat aaaagctctt 389041 cgtacgagac cattgtgata tcctcgggga aatcagggtg tacggcgcat acagccattt 389101 tgtagccggg atcgacctca tacgttttga tatagcatgg ggaatggctg tccggaagct 389161 caatggatac ttgtccgtcc tggtgcaggc gcactgaaaa ggaatcaagc ggaagcgata 389221 agcctttgcc ttccttgttt gataaagctt tctttcattg accatagatg ataaaaatag 389281 tctgtctgct cgtccttgtc ttttgctaaa aggtcgctgt actctgtttt tgaaaagaag 389341 cgcttggcga tctcaaggct gatcggtttc gttttttcga tatctatgcc gatcggctgt 389401 gaatcaaacg cgcaaatgac ccagcgtccg gagtgagaaa tgttgaaatg agcgtcggga 389461 agatcaggga tgcacggctt cccgtattcc tgcgtgctaa agcggatatc ggatttgtcc 389521 aactgatact gcctgcttat gactgagcga acgagcacat ctcccagcag ggtgcggtga 389581 gcatcttctt tatgataaaa tctccggcat ttctcccgtt tttcaggtga tatgaaagac 389641 atgaaccgtt cattttcttc ctgtgaaagc gggcggtcca tataaattcc gtaaatcttc 389701 attctagatc ctccgtctgc aaaagattgt caaaaccatc ctatcatact tccacaagac 389761 tcatatagag gagaaaataa aaaaacaaag ccaaggcggc tttgttttag tgtacaggcg 389821 gagatgcttt cactgcggct gtccgccttg ccacagcata attcagcaac tggattgact 389881 ggggcaatga aaaacgcaaa ataagtccgg tgaggatggc ggtcaaaatg gtgccaaaac 389941 cgatcggtcc gcccatgccc catgccgcaa acaaaatggt taattccatg ccgttccgca 390001 cccattgcac attccagccg gttttttctg taatcagcat catcagtgaa tcacgcggcc 390061 ccgcgccaag gcctgctgat acataaacac cgacgccgta accaatcagc accacgccta 390121 gagagaagac gatgatcgag cctgtgtagg tcgagagggc aggcagaatg aaattgaaaa 390181 aatctataaa tacaccaatg agcaccatat tcaggagggc accaattttc ggccaagctc 390241 tcgtaaacaa tgacgtgaat ccgacgatga gcgctccaat aatgatggac cactggccga 390301 cggtaagccc gaagtgctga aacaggctgt aatgaaatgc atcccacgga ctaatgccga 390361 gtgcttttcc ttctatcgtc agggatacac caaaagccaa aatgatcaaa ccggcaaaat 390421 aaaatgtcca gcgcagaaca agttcttgct tcacgtgagg tcccttcttt cgtaaaaatc 390481 agtcgattgt cattgtagca catctgacag aagggcggaa taggcgaaag gggctcaaca 390541 aaaaaacagg gccgccggag gcgccctgtt tcagcgtgtt ggcaaaccct tgcattcgtt 390601 gtcaggcctg tgcttcggtg ctcacgaatt taacattagc tgtgctccaa tgctcgccct 390661 tcctagactt caaaggtttt caatcacgct gaaaatcaca aaatcctaaa acgaatatcg 390721 ttttaggatt ttgtcaataa tctgaaacag ggcgctgacg ctctgttttt cttattacag 390781 cgggttcaaa atccggttta agaaccgctg tgtccgttct tcttttggtg cggagaaaat 390841 ttgctccggc ggtccctgct ccacgataac gccgccgtcg atgaagatga cttcatccgc 390901 aacctcctgc gcgaacttga tttcgtgggt cacgacgacc atggtccagc cttcattggc 390961 caagtccttg ataaccttca gcacctctcc gacaagctcg ggatcaagcg ctgaggtcgg 391021 ttcgtcaaac agcatgagct caggctgtat cgccagtgcg cgggcgatgc cgacgcgctg 391081 ctgctggccg ccggaaagct ggaacggata taaatccatt ttgtccttca atccgacttt 391141 atcaagaagc tgaatcgctt cttttctgac ttcctctttg ttccgttttt gcacctgaac 391201 agggccctcc atcacgtttt cgagggctgt gcggtgcggg aacaggtgat acgcctgaaa 391261 caccattccg gattttcggc gaagctttag gatatccgcc tgtttcacct ttttggagaa 391321 atcgatggag aaatcatcaa atgcaagctc tccgcgattc gggatctcca gagcgttcag 391381 gcagcggagc agcgtcgttt tccctgaacc tgaaggccca agtatggcga tgacttttcc 391441 tttttcaatc ttcatatcta tcttttttaa aatttcattt tcaccgaatg atttgtttaa 391501 tcctttaacg gtaagcatac tcggaacctc cttatttggc cacgtagcgg tcaagacgcc 391561 gttcgatgac atgctggacg agtgagagca ggaagcagat aatccaataa ataaaggctg 391621 cttcaatata gatcactaaa atttgatcaa gattccgcgc gccgatttcc tgggcttttc 391681 tgaacagctc agcgaccaga atttgagagg cgagggatgt atctttaatc aggctgataa 391741 aggtattgga taatggcggg atcgacacac gaaacgcctg cggcaaaatg acgcggaaca 391801 gcgttttttg atgtgtcatg ccaattgtgt agccggcttc ccattgccct ttcggcacgg 391861 ataaaataga tgcccgaatg atttcagatg cataggcgcc gacgtttaat gaaaaggcga 391921 taactgcgct tggaaatgga tctaatgtga cgttaaaggc cgggaacaga tagaaaatga 391981 tgaacaattg aacgagaaga ggagtgccgc gtattgcgga tacgtatacg ctgaacaccc 392041 atctcaaagg tctcactttc gacattctgg caagcgccgt aatcagcgcc aggatcattc 392101 cgaatataaa ggaaagaatc gtaaggggaa tcgtatagta gattccccct gaaagtatcg 392161 gccagaatga ctgctgcacc agatcccacg ggatcgccgt gccaagcgtc aatgccggca 392221 gattatttag aaacatcttc gccgaaccat tttttagaaa ttttagaaag agtcccgtcc 392281 tctttcattt cttttaatgc tttgttgact tgatcaacaa cctcgccgct tcctttacgg 392341 aacgtgaaat atgttgactg aggctcacct gtttcaaacg cgattttcac gtttttattg 392401 ccagatgttt ttaagtagtt caatacggca agcttatcgt tgtatgtcat atcgacgcgg 392461 ccttgctgga tcatttgaag ggcctgcgcc atgccttcaa cgccttctac tttagcgccg 392521 gcatttgtag ctaatttgtt gtagttgctt gtcagtgatt gagctgacgt ttttcctttt 392581 acatctgctt cagacttaat atcgttgttg tcttttttcg ttacgacaac ggctcttgat 392641 gttgtgtatt tatctgagaa atcatatttg tcttcacgat ctgtttttcc gacttggttg 392701 gcaacaacgt caaaccgttt ggaattcagg ccggcaaaca tactgtccca ttgtgtttcc 392761 ttaaagtcga ctttaagccc gaggcgtttt gcgacttctg tgataacttc gacatcatag 392821 ccagtcagtt tatcagtgtc tttgtcgtgg taagtgaacg gctcatatgt tccttccgtt 392881 ccgactgtga gcacaccttt tttcttaatt gaagcccaaa gatcgccatc tttggcatta 392941 tcttttgact gattgtcatt tcctgctccg caagctgcaa gagctgcaat acttacgacc 393001 atgaataaag ccaataatgc ttttttcatc ttattcccca cttttctggt tgattttatt 393061 gaaataaaaa attagcttac aaatctaaag gataactttt ttttagtatg agtcaagtat 393121 ttggttttca taagacaaaa tcttttaaaa taaatccaaa aattgctgtg ccggtttagg 393181 caaataactg tccgttctcc acatgacagc cggtgtcata atgaagggat tattttcgat 393241 atggacggtg tgaacgtgat ttctcatatg aacgggaatc attgtgacag gcaaaataga 393301 cgcgccgaat ccggatgaca cgaggctgag caaagttgca gagtcgtggc attcacaaac 393361 aatgcgcggc tccaggttca aacgatgaaa ttcattcatg acctgattat agacgccttt 393421 tccgttgaca ggccgcagca ggatcagcgg aaatgaagga atgtccacca tcttaatggt 393481 gtctccgcac ggatatccgg cttcatctga aagcacgagc acacatggaa tgtcatcaag 393541 ctgcttgaat tgtactgtgt cacttttgat cagtgttgtc gtgaccgccg catcgatttg 393601 ccggctttcc agcagttcca acagtgtcgc gggttcattt tcccaaatat taaaggtgag 393661 atgggggtat ctctctttga tctgtgttac tttttcaagc atcagagccg cgcaataaat 393721 cgttgatccc acggcaagtg taccggctac ttcctccttc agctcctgta cctcaatgac 393781 tgcatcttca aacctatgca gaatctcttt tgctcttttt agaaaaacag ctccttcata 393841 tgtaagagtc atttgttttt tcttgttacg gtcaaacaga acaacaccaa gttcgtcctc 393901 cagctgtttg agctgcctgc ttaaaggcgg ctgcgccatg tgaagctttt tggctgcgga 393961 cgtaattttc tgttcttggg caatggtaat gaagtatcga agctggcgaa tatccaaaag 394021 aaagcgcctc cttatcatac cttttaggta ttaattatag atttaataga tatttttcat 394081 atggatatat caggagtatg attgaaatga aagcagaatt caagcgtaaa ggagggggca 394141 aagtgaaact cgttgtcgga atgacagggg caacaggggc cattttcggg gtcaggctgc 394201 tgcagtggct gaaggccgcc ggagtggaaa cccatctcgt tgtgtctcct tgggcaaacg 394261 tcacgatcaa acacgaaaca ggctatacgt tacaagaagt agaacaactg gccacataca 394321 cttactcaca taaggatcag gcggcagcca tttcaagcgg gtcgtttgat accgatggaa 394381 tgattgttgc gccgtgcagc atgaaatctc tcgcaagcat tcgcacagga atggcggata 394441 atctgctgac acgtgcggcg gatgtcatgc tcaaggagag aaaaaaactc gtcctcttaa 394501 cgagagagac gcctttgaac caaattcatc tcgaaaatat gctagcgctt acgaaaatgg 394561 gcaccatcat tcttcctccg atgccggcat tttataatcg gccgagaagc ttagaggaaa 394621 tggttgacca tattgttttt agaacgttgg accaattcgg cattcggctt cctgaagcga 394681 agcgctggaa tgggattgaa aaacaaaaag gaggagcttg atcatggctt atcaagattt 394741 cagagaattt ctcgctgccc ttgaaaaaga aggacagctg cttacagtga atgaagaggt 394801 aaagccggaa ccggatttag gggcctccgc acgggcagcc agcaatcttg gcgataaaag 394861 ccctgcgctc ttatttaaca acatttacgg ctatcataac gcgcgaattg cgatgaatgt 394921 catcggctct tggccaaacc atgccatgat gctgggcatg ccgaaagaca caccggtaaa 394981 agaacagttt tttgaattcg caaagcgtta tgaccagttt ccgatgccgg tcaaacgtga 395041 ggaaacagcg ccatttcatg aaaatgaaat cacagaagat atcaatttgt tcgatatact 395101 gcctcttttc agaattaacc agggtgatgg aggctactat ttagacaaag catgtgtcat 395161 ttcccgtgat cttgaggacc ctgacaactt cggcaaacaa aatgtcggca tttacagaat 395221 gcaagtcaaa ggaaaagacc gccttggcat tcagcctgtc ccgcagcacg atattgcaat 395281 ccatctgcgc caagctgaag aacgcggcat caaccttccg gtcactattg cgctcggctg 395341 tgagccggtc attacaacgg cggcatcgac tccgcttctc tatgatcaat cagaatacga 395401 aatggcaggt gcgattcaag gcgaaccata tcgcatcgtc aaatcaaagc tgtctgatct 395461 tgatgttccg tggggcgctg aagtggtgct tgaaggtgag attattgccg gagagcgcga 395521 atatgaaggg ccgttcggtg aattcacagg ccattattcc ggcggacgca gcatgccgat 395581 tatcaaaatt aaacgcgtct atcacagaaa caatccgatc tttgaacatt tatacttagg 395641 catgccttgg acagaatgcg attacatgat cggcattaac acatgcgtgc cgctttatca 395701 gcagttaaaa gaagcgtatc cgaacgaaat tgtggcagtg aacgccatgt acacacacgg 395761 tttaatcgcg attgtttcca caaaaacccg ctatggcgga tttgcgaaag cggtcggcat 395821 gcgcgcactc acaacgccgc acggactcgg ctactgcaaa atggtcatag tcgttgatga 395881 ggatgtcgat ccattcaacc ttccgcaggt catgtgggcg ctttcgacca aaatgcatcc 395941 gaaacatgat gcggtcatca ttccggactt atctgtcctg ccgcttgatc cgggatccaa 396001 tccatcagga atcactcaca aaatgattct cgacgccact acaccggttg cgccggaaac 396061 aagaggccat tattcacagc cgcttgattc tccgctaaca acgaaagaat gggaacaaaa 396121 actaatggac ttaatgaata aataaggaaa ggatgttcga aatgcataca tgtcctcgat 396181 gcgactcaaa aaagggagaa gtcatgagca aatcgcctgt agaaggcgca tgggaagttt 396241 atcagtgcca aacatgcttt tttacatgga gatcctgtga accggaaagc attacaaatc 396301 ccgaaaaata caatccagcg tttaaaattg atccaaagga aacagaaaca gcaattgaag 396361 ttccggcggt gccggaacga aaggcttgat ccgcgtgaac tgtatgtcag accgtctctt 396421 tgagctgctt gacgggagct gcctgaatga gaagcagcat gaggccttcg ttctgcaaac 396481 agtatcagag gatggctggc cgcatgccgc tatgatcagt gcaggtgaaa tcatcgcgct 396541 gagccgaact gatatccgaa tcgctctgtg gaaaaacaca atgacttcgg ccaacatcct 396601 tcgcacagga aaagcacagt tcacggcgtg gtggaaggga gcggcctatt atgtaaagct 396661 tgaatgcgcg cctttaccgc ctttgaaaga tgccgaatat gaaagagacc gtttttcctg 396721 ccgcatcgtt tcagtgaaag aggacgttgc gaaatacgct gatttgactt caggtgtccg 396781 tatacagctt cacagccctg aagaggtgct gagcagatgg aaaaagaccc tggaagattt 396841 aaaacggtaa tatcgatagc ctgacgccat gcgtcaggct ttttttatat aatgaaaaca 396901 aaagggggcg tgagaaatgg aacgtgcggg gatctgtcac tcggacggct ttgatttagc 396961 ttatcgaatt gagggcgagg gcgcacccat ccttgtgatc gggagtgcgg tttactatcc 397021 gcgccttttt tcctcagata tcaaacagaa atatcaatgg gtctttgtcg accatagggg 397081 atttgctaag cctaagcggg agcttcgtgc ggaggattcg aggcttgatg ctgtcttggc 397141 tgatatcgaa aggatgagaa catttcttca gcttgaggat gttactatcc tgggacattc 397201 cgggcacgct tttatggctt tagagtatgc caggacatat cccaaacaag ttcggaaggt 397261 ggcgctcttt aatactgcgc ctgataacag tgaagaaaga cagcgaaaaa gcgaatcatt 397321 tttcatggaa acagccagtc ttgagagaaa gaaacgcttt gaaaaagaca tcgagaattt 397381 gccgcaggac atcgacaaag atcctgaaag gcgctttgtg cacatgtgta ttcgcgctga 397441 agcgaaaagc ttttatcaag agcggccgca tgctgctgcc ttatgggacg gtgtattcac 397501 gaatatgccg atcattgatg aattatgggg caatacattt gcccggattg atcttcttca 397561 gcggttagct gatgttcgta tgccggtgta tatcggatta gggagatatg attatttggt 397621 tgcgcccgtt tcgctatggg atgctgttga cggtttatat ccccatgttg ataaggttat 397681 ttttgaaaag agcggccatc agccgatgct ggaagaaccg gaagcctttg atcaaagctt 397741 caggaaatgg cttgatcaat aaaaaacagc ccgcagatca acatccgcgg gctgtttctg 397801 attataagac ccctttcatc gcgcgtttga tcaccggcga gagcagcagg agaatgccgc 397861 caagaacgat agaaatcaaa ccgatggtgc cgaagtacat tgtttcagga attttatcaa 397921 acaatccggc tacttgggca ttgatcgctt gggctgctgc gttcgtcaga aaccacatac 397981 tcattgtctg tgcagagaag gcagctggtg ccagtttcgt tgtcacggat aaaccgactg 398041 gagacaggca cagctctcca agcacgacaa gcaggaagct gagaacgagc caaagcgggc 398101 ttacgagtgc ttcttttcct tgcatagcag ggaataccat aatgataaat gacaatccgg 398161 ctaaaataat tccgattgag aatttaactg gtgtagacgg ctgacgtttg ccaagcttca 398221 tccagagcca tgcgaatatt ggcgcaaaaa tgacaacaaa caatggattt aatgattgga 398281 accatgatga ctgaagttcg aatccgccca atgaaagtct tatgcgttca tcagcgtata 398341 ccgcaagaat ggtcgctccc tgttcctgaa tggcccagaa catgacagca ccgataaaca 398401 aaggaacgta agcggcaaga cgggattttt ctgttttgtc cgcttttttg cttgtaaaca 398461 tgatgatgaa ataaatcaca ggaatcaaaa taccgagaat acttacaagg tcaatgaaac 398521 gtttgatcgt cagcacgcct gtttgtacag agataatcac tgcgatcgcc acaatgataa 398581 caccgattcc ggtgccaatt gcagattttt tagacagcgg attcggcaca ttggaacctg 398641 caagcccgag gtttttcttt cttgtcaaag caaatacgat aagtccgaga agcattccga 398701 ccgcggcagc tccgaatccg agatgatagt tgtacttctg tccgagtgtt ccgacaatta 398761 acggcgcgag taaaccaccg aggttaatcc ccatgtagaa aatactgaaa cctgagtcgc 398821 ggcgcgggtc ttctttcgtg taaagatccc caactacgct tgaaacgttt ggttttaata 398881 agcctgttcc gacaatgata agcaccatac tgatatagaa tgctatcgaa ctgcccggat 398941 aggcgagtgc aatgtggccg aacataatga atatgccgcc gtaaaacacg gtgtttgcgg 399001 taccgaatac ccggtcagcg agccatccgc caataatggt ggacatgtat acgagtgatc 399061 cgtaaatcga cataatggca accgcagtgc ccttgtcaaa gccgagccct ccgtttaccg 399121 tctctgtata caaatagtaa agtaagattg ctctcattcc atagtaagag aaacgctccc 399181 aaaattcggt gaaaaatagt gtaaatagtc ctcgcgggtg accaaagaac cctttttgcg 399241 ggacgctttt aatgatactt tcgttatcaa tcgaagccat gtcagccaaa ccctttctaa 399301 aaaaagtgta ttataaaaat catattctta tataatactt gtgtcaatat aatttatact 399361 catttcaaat agttccatat tggaaaaatt ataaatacct aaaaatagtg atttcctcct 399421 aatttttaaa ctttttatcg tgagattttc ttacacaact attcctttat atttttttaa 399481 taaaatttta gagaaatgta caagcagatc gggaggaccg ctggtgaatc aatcccctgt 399541 aacggggatt tttttatgtc cgtaaaccgc tttgaaaagc cgctgcacac cctcctgaat 399601 atcttcttcc ttcagccgtg caaagccgat aatgagagca ggcctgcccg tttgccgctt 399661 gttttccttc aagttaaatc ggctcattcc gaatatttca agctgcagcc cggcagcatg 399721 tgacaggatg tcttgttcgg tgcgcctggt atcaaattcg gtaacaaaat gcagccccgc 399781 atttgcccct tttacggtaa cctctccgct gaactctgct tctaaagcgg tgatcaggcg 399841 ttctctcttt tctttataat gctgcttcat tttttttata tgcttctgat attcaccaga 399901 ctcgataaat tcctgcaggg tgagctgtgt gagtgatgag caagtctgca gatcatagcc 399961 ccgctgtttg tatgccctca acagctcagg cggcaacacc atatagctga tccgtaagcc 400021 ggggagaagg gactttgaaa aggttcccat atagatgaca ttttgaaaac ggtcgaggct 400081 ttgcagcgcc ggaatactgt ctacatcata tgtgaattca ctatcataat cgtcctcaat 400141 gatatatcgg cgcggctcct cggctgccca gttcagcagc tgaattcttc tggatacagg 400201 cataatcgtt ccggacggaa actgatgcga cggggtggtc accagcacat ctggctgctg 400261 tctggtgatt tcagcaatcg acatgccttt ttcatccagc atgatcgtct ttacttgttt 400321 tccggcattc ttcaaaagct gatacatgcg cctgtagcca ggctcctcca tcgcatacac 400381 ggcttccttg ggtaaaagct cagtcaacag ctgcatgagc acctgtgtgc ctgcccctat 400441 gatcatttgt tccggcctgc attttacacc cctcgtcagg gaaatgagcc tcgtaatggc 400501 cgctctcact tcatatatcc cttgcggatg tgacatatcg ccgagcgtgc ggtatgagcg 400561 ggaggccgct ttttgctcgc agcggaacca gcttttgatc ggaaaatggt ctgtatcgga 400621 actcatgtgt gaaaacgata tccaatcgct ctggtcgatg tgaatctctt ttaggtcatc 400681 cggcagtgca aatggagggt gctcctcggc ggaaaacatg tctagttcct ccacgaagaa 400741 accctttcgt tcaatggcgt acaaataccc ctcagccagc agctgctgat aggctgaatt 400801 cactgaattt acgctgacct tgagattttc agccagctcc cgcttggagg gaaccttcga 400861 gtgcggcagc agattgcggc tgaggatttc ttttttcagc ttttgataaa tttgctgata 400921 gatataatcg gcttgttctg aacgatcgag tgtaatcgtg atatccattt tgtagtttct 400981 ccttctgata ccatcaaaaa gttataattg gtacttttca tcataccaaa gagaagtcag 401041 aatgataaga aaataccgac agggggatat tcacatgagt caaacaacag caagcatcac 401101 aactgcacaa tggcagcaaa aacgggatca atttgtgtca aaaggtgtga gcaacggcaa 401161 ccgcagtctg gcggtcaaag gagaaggggc cgagctgtac gatctggatg gccggagatt 401221 tattgatttt gcaggcgcca tcggcacgtt aaatgtcgga cactcgcatc cgaaggtggt 401281 tgaggctgtg aagcggcagg cggaggagct gattcatcct ggttttaatg tcatgatgta 401341 cccgacttat atcgaattag cagaaaaact gtgcggcatc gcgccgggca gccatgagaa 401401 aaaagcgatt tttcttaact caggggcaga agcggtcgaa aacgctgtga aaatcgccag 401461 aaagtataca aagcgccaag gcgttgtctc gtttacacgc gggtttcacg ggcgcacgaa 401521 tatgacgatg agcatgacaa gcaaggtaaa accttataaa ttcggtttcg ggccttttgc 401581 gccagaggtt tatcaagcgc cgttccctta ttattatcag aagccggccg gcatgagtga 401641 tgaaagctat gacgatatgg tcattcaagc attcaatgat ttctttatcg cttcagtggc 401701 gcctgaaacg gtggcgtgtg tcgtgatgga gccagtgcag ggagaaggcg gatttattat 401761 tccttcgaaa cggttcgtac agcacgtcgc ttcattctgc aaagaacacg gcattgtttt 401821 tgttgctgat gaaatccaaa ccggctttgc cagaactggc acttatttcg caattgagca 401881 ctttgatgta gtgcccgatc tgatcacggt ttctaaatcg cttgcggcag gcctgccatt 401941 aagcggtgtg atcgggcgtg cggaaatgct tgatgcggca gcgccagggg agctgggcgg 402001 cacgtatgcc ggcagcccgc tcggctgcgc ggcggctttg gcagtcttgg atattatcga 402061 agaagaagga ctgaatgagc gatctgaaga aattggcaaa atcattgaag acaaggcgta 402121 tgagtggaaa caagaattcc cgttcatcgg tgacatccgc agactcgggg cgatggccgc 402181 aatcgaaatc gtcaaggatc ctgacacgcg tgagcctgat aagacaaaag cagcagcgat 402241 cgcggcctat gcgaatcaaa acggattact tttgctgaca gcgggaatta acggtaatat 402301 catccgcttt ttgacaccgc tcgtcatctc agacagccta ttaaatgaag ggctcagcat 402361 cttggaggcg ggcctgcgag cttaatcatt ggaaagaaaa tggccgggtc tgctatcatt 402421 ttaagtaatc atgaaaagaa aggaatgttc aatatgccag atcaattaac ggtctacaac 402481 ccggctacgg gcgaggagat caaaacgatt cctcagcaat cagccacaga ggtagaagaa 402541 gccattgaac gttcacatca agcgtttaaa acgtggtcta aaacatcagc gaacgaaaga 402601 acgtctcttt tgaaaaaatg gtatgagctg attgttgaac ataaagaaga gcttgcagat 402661 ttaattacaa aggaaaacgg aaaaccatac caggaagcag tcggcgaggt actttacggc 402721 gcaggctata tcgaatggtt cgcagaggaa gcgaagcgtg tgtacggaag aacggtcccg 402781 gccccgacaa ctggtaaacg aattgttgtc acacgccagc cggtcggccc cgttgctgct 402841 atcacgccct ggaatttccc gaatgcgatg attacacgca aagcggcgcc tgctcttgcc 402901 gccggctgta catttatcat caagccggcg ccggacacac cgctgtctgc ttatgaacta 402961 gcgcgcctcg catatgaagc gggcattccg aaggatgttc ttcaggttgt gatcggcgat 403021 ggagaagaaa tcggaaatgt gttcacaagc agtccgaaaa tccgcaaaat cacgttcaca 403081 ggctcaacac ctgtagggaa aatccttatg aaaaacagcg ctgacaccgt aaagcacgtc 403141 tcaatggagc tcggcggaca cgccccgctg atcgtagatg aagatgcgga cattgacctt 403201 gccgttgaac aggcgatggc gtccaaatac cgaaacgccg gccaaacctg cgtatgtgcc 403261 aaccgcctga tcgttcatga atccattaaa gatgaatttg ctgcgaaact gagcgagcaa 403321 gtgtctaagc tgaaagtcgg aaatggactt gaggaaggcg tcaatgtcgg cccgattatc 403381 aacaaacgag gcttcgaaaa aatcgtcagc caaatagatg atgcggttga aaaaggcgcg 403441 aaagtgattg ctgggggcac atatgaccga aacgatgaca aagggtgcta ctttgtgaat 403501 ccgacagtgc tcaccgatgt cgatacgtcc atgaacatca tgcatgagga aacattcggc 403561 ccggtcgccc cgatcgtcac gttttctgat attgatgaag cgattcagct tgccaacgat 403621 acaccgtatg gcttggctgc ttacttcttc acagaaaact accgccgcgg catctatatt 403681 tccgagaatc tagagtatgg cattatcggc tggaatgacg gcggaccgtc agcggttcaa 403741 gcgccattcg gcggaatgaa agaaagcggc atcggccgtg aaggcggttc agaaggtatc 403801 gagccgtacc ttgaaacaaa atatttgtcc atcggtttat aaaagaatgc acgctcctga 403861 gagctgccgg attttccggc agctcttttt gtgttccggc gaataatcac aacaattcca 403921 gccaaaataa cagcaaatac attttgaaag aaggttcccc aacaatggat ttattattgg 403981 ctcttctccc ggctttgttt tgggggagca ttgttctctt caatgtgaaa ttaggcggcg 404041 ggccgtacag ccagacactg ggaacgacga tcggggcact cattgtttct atcgttattt 404101 acttttttgt tcagcccgtt ctgtcccttc gcatttttat tgttggaatc gtatccggct 404161 tattttggtc acttggacag gccaaccagt tgaaaagcat tcaattgatg ggcgtgtcga 404221 aaacaatgcc gatttccaca ggaatgcagc tcgtttccac ctcgctgttc ggtgtgatcg 404281 tgttccgcga atggtcaaca ccgattgcga ttacgcttgg cgttctcgct ttgatcttta 404341 tcattgtggg aatcattctc acgtccttgg aagataagaa tgataaaaaa gagggcgagc 404401 caagcaattt gaaaaagggc attttgattc tccttgtttc gactcttggt tatttggttt 404461 atgtagtcgt ggctagatta ttcaatgtgt ccggctggtc cgcgctgctg ccacaggcaa 404521 ttggcatggt ggtcgggggg ttagttttaa cctatagaca caaacccttt aacaagtatg 404581 cgatcagaaa tattctccca gggttaatct gggcaggcgg aaatatgttt ttgtttattt 404641 ctcagccgcg agtcggcgtt gcaacgagct tttccctttc acaaatggga attgtcattt 404701 ctacgctcgg cggtattttc atcctgcgtg aaaagaaaac gaaacgccag ctaatagcaa 404761 ttgcgatcgg gattatcctg attattgccg ccgccgtatt cttaggaatc gccaaaacaa 404821 attcataaca aatggaggag gatgtatatg tatccggatt taaaaggaaa agtcgtcgct 404881 attacaggag ctgcttcagg gctcggaaag gcgatggcca ttcgcttcgg caaggagcag 404941 gcaaaagtgg ttatcaacta ttatagtaat aaacaagatc cgaacgaggt aaaagaagag 405001 gtcatcaagg cgggcggtga agctgttgtc gtccaaggag atgtcacgaa agaggaagat 405061 gtaaaaaata tcgtgcaaac ggcaattaag gagttcggca cactcgatat tatgattaat 405121 aatgccggtc ttgaaaatcc tgtgccatct cacgaaatgc cgctcaagga ttgggataaa 405181 gtcatcggca cgaacttaac gggtgccttt ttaggaagcc gtgaagcgat taaatatttc 405241 gtagaaaacg atatcaaggg aaatgtcatt aacatgtcca gtgtgcacga agtgattcct 405301 tggccgttat ttgtccacta tgcggcaagt aaaggcggga taaagctgat gacagaaaca 405361 ttagcgttgg aatacgcgcc gaagggcatt cgcgtcaata atattgggcc aggtgcgatc 405421 aacacgccaa tcaatgctga aaaattcgct gaccctaaac agaaagctga tgtagaaagc 405481 atgattccaa tgggatatat cggcgaaccg gaggagatcg ccgcagtagc agcctggctt 405541 gcttcgaagg aagccagcta cgtcacaggc atcacgttat tcgcggacgg cggtatgaca 405601 caatatcctt cattccaggc aggccgcggt taaacataaa aagcgaccca gacatgacat 405661 ctggatcgct ttctttatta ggcacgcttt ttctttacaa gtgctgctac agataaaata 405721 atggcagccg cagacagcac catcgctgta atgtctagag ctgaagaacc tgagttttcg 405781 gaatcgtctt ctgttttcgt ggcgccgtgc tcatctgtca cttgctttgc agacgtgatg 405841 tttgtaatgg aatgaggtgt atcggcatcc tcgtcacctg tccactcaac aatgctgccg 405901 tctttgtaat attggtatgc gtcccaagca gcttcctccg ctttgtcagg gtttttggca 405961 acaaaggtaa actgctggaa ctggccttcc tgaatgcctc cgtcagtcgc ctcccatgtc 406021 acggatactg atttgtcatc atgtttttga gtggaaacct tccagcccgg aattggctca 406081 tattgctgga attcaacatc cttcggcatt ttgaggacaa ccttcgttgt cggcagattt 406141 ttctcagaag gaaccttcat tgtatacgtt tcccaagagc ctgcagcaga ctcagccggt 406201 tttacagaaa catgcgcgct ggcaggggcc gtaaagaata agagggagcc gacaatagcc 406261 ggacatagtg tcaatgcgat ttttttcaac aacgtaaaca ctccttaatt ggtctttgta 406321 aacatgatat tgatttcgtt aaagtcgccg gtcaggccgt ggactttgat cttccagttt 406381 cctttttcat taatcgacag gttttgatct tggaagacgc cttttgtttt ttcttttaat 406441 gtaaaggtgc ttttgttttc gctgcctgac aggcctgttt tataaacggt taacgtgatt 406501 tgctggatgt ttttcacggg atcaccgtta tggtcggtga cccgcagctc aaaaacattt 406561 tttccaggct ggtttgggct gatgctgaga gaaacgcttt gtccgttctc tatcgctttg 406621 gtttggtaga acggttccgg cgctggctca ggcgggcttg gcaggcttgt aaacacggcc 406681 gctgtgatca atacagcgat gccgattgcc cactccgctt tcaacgttcg gctgattcct 406741 gtgcggcgct gctttctggt aagcagaaaa tgaattgcgc ctaagaccag catgaaaaca 406801 aacagcccgc ttttcactaa aagagcttgt ccgtacgctg tatggaacag tgaatccatt 406861 gaacgaatga tgaaaaatcc attgagcaag cctgaaaaca aaatgacgcc gactgcagtg 406921 agcgcccatg gggagaaccg tctgaccgtc tcccacgcga gcgttttgtc aggctgcctc 406981 cattcttttg agagcagcaa aacgagtgcc gctattccgc cgacccagat ggaagcggaa 407041 gttaaatgaa ggaaatccat caaaatgccg accgtttttt cttcaacgac agcagcatgc 407101 ccggtaaacg ccttggcaag caggagaccg aaaaagaaaa tgagcggcgc tgtccaatag 407161 ccaaaggatg aaaagcggtt tttccgtatc gcagggatga cagacagtgc gagcagcacg 407221 aacagcgcag cctgtatgat ccaaatggag ccgcctgctg tctcaaacag tgtttctctg 407281 atgtagcccg gctggaatgc gctgccccag ccgccgcctg cgttcgcttt tgtctgaatc 407341 ggaagctgaa gcaaaagcgc cagccccaat gctgcgatcg agccggtcag gatacgtctc 407401 gtccgtttga cgagctgttc tgatttccct ttataccaga aaagatggaa gaaaaccgtt 407461 ccgataaaca gagataaggc tgtatacaga atcgcgcgat ctgctgctgt tcccggattc 407521 agcgctgaat cggctgcttt ttggctgctg aatccgccat ccgctttccc gatactgaac 407581 ggaatgacgc cggaaacagg atgtccatcc gcggatacgg cattccattc cgctctgtac 407641 acatctttag gcagattctt cttcagcttc actgtcatga tgtgatgatt atcttttttg 407701 atttcagtct tgtccgtatc cacacggtcg ccgtttgaat tatagacttt aatgtaatga 407761 aacccttctt caaccggttc attaaattcg atttccacct gcgcaggggc gctttttaat 407821 tcgctgtttt ccccaggtga agatttgaca atataggcgt gagcaaagct tgttttcggc 407881 aggaaaacaa gaaaaagcag aaggatgatc caccatctgt ttcgcttcat cactcagaca 407941 ccaccttccg ctgtatgtgt tgtgttattt cttggtgcag gtgcagcgtt tctttcggtc 408001 ttgaagcatg tcttccagcg cttggtcgaa agtgcagacg gctccgccga atcctttttg 408061 aaatcgttcg gcatggtcaa gtgtcgcaaa cggaatggcc tgcggctggc agcagtgcag 408121 gtttaattca gcatttacga cgaaataagc cgaaccggca ctgacggttg tctgtaacag 408181 aaaatctctg caaatcaagt gtgaaacctc ttccgtttta tccgcgtaac gcaaaaacgc 408241 gcaatgtgcg cagcatagct gttcaatgtc ttggtttacc gtaatcagct gaaccgaatg 408301 agcttgattg acgggcttca agcaatagct gcacatatga tctgtttgag gtgttcggac 408361 ggggagcgtg atgccgccgg ccgttttaat gacctgattt gactgaacca gctgattgac 408421 atctctatat accgtcattt ccgaaacgcc gaaccttgcg ctgatgtcag aaattctaag 408481 cgagccttct tctttcagcc acttcagtat gtgttgctgt ctattaatcg gaagcattca 408541 tacaccctct tcattaagat ctatttaagc gtagaggatt ttagagacgg agacaagtaa 408601 gtggatgata aaaaatgtga aaatgtgttg aacagcaaca aaacgaaaca gaagggactc 408661 tggtataata gacagatgga atagaaagtg aggaataccc tatgaaagaa acaccatgcc 408721 cgaactgcgg caaacctttg acaggcgata tggtcagatc atcaaatgtg ccttgtcaat 408781 ttcgctgcgg ccactgccgg gaacggcttt atgaatataa agtttcagct ccgattatgc 408841 tggtatcatt agcggccatc gtgctgctta tttatctttt gatgctcctc cgcaatgcgg 408901 caggctcagt gctgccagct gtacagcacg tgccgatggc tgtatttgcg cttgtgtgcg 408961 cgtatcccgt ttttattgtg agtgagcgga tgattgcaaa gtacgtgatt caaaatggca 409021 acatcattta tagaggaaag agaaaaggct cctgaaacca ggagcctttt tatttttaaa 409081 aaattgtcac agtcatgtgc caaagtcctc tttactttca attgtatagg gactgtaagc 409141 gttttaacat agagtcaaag ggaagcatca ttctctgaac atatttttgt atcttacagc 409201 gacaaacaaa acagggaggg tttatatatg cagcagcaag aacagcagca aggcggcatg 409261 aaagtgaaag tgcaacgctt tgggagttat ttgagcggaa tgatcatgcc gaatatcggc 409321 gcgtttatcg cgtggggtat cattaccgcg ctgtttattc cggcaggatg gtttccgaat 409381 gaacagctga acacgctggt cagcccgatg attacgtatt tattgccgct tttgatagcg 409441 tatacaggcg gaaaaatgat ctacgaccac cgcggcggag ttgtcggagc gacagcggca 409501 attggggtga ttgtaggatc ggatattcca atgtttttag gcgcaatgat tatgggtccg 409561 cttggcggat acctcattaa acagactgat aaattattca aggataaagt caagcaaggc 409621 tttgaaatgc tgatcaacaa ctttacggca gggattgtcg gcgcggcttt aacgattctc 409681 gcgttttacg ccatcggccc ggttgtcttg acgctaaata aattgctggc ggctggtgtg 409741 gaagtcattg tacacgctaa tttactgccg gtagccagtg tttttgtaga accggcgaaa 409801 gtgttgttcc ttaacaacgc cataaaccat ggaatcttaa gcccgatcgg aatcgagcaa 409861 gcatctcaaa caggaaaatc aattctgttt ttagtagaag caaaccctgg accggggctc 409921 ggcattttgc tggcctacat gttctttggc aaaggatctt caaaatcaac ggctcccggt 409981 gcggcgatca tccatttctt cggagggatt cacgagattt acttcccgta cattctgatg 410041 aaaccggccc tgattctcgc agccattgcc ggcggagcaa gcggactctt aacatttacg 410101 atctttaatg ccggacttgt cgcggcagcg tcaccgggaa gcattatcgc attgatggca 410161 atgacgccaa gaggaggcta tttcggcgta ttggcgggtg tattggtcgc tgcagctgta 410221 tcgttcatcg tttcagcagt gatcctgaaa tcctctaaag ctagtgaaga agacctggct 410281 gccgcaacag aaaaaatgca gtccatgaag gggaagaaaa gccaagcagc agctgcttta 410341 gaggcggaac aagccaaagc agaagaagcg tctgagctgt ctcctgaaag cgtgaacaaa 410401 attatctttg cgtgtgatgc gggaatggga tcaagtgcca tgggggcatc catcttaaga 410461 aacaaagtga aaaaagcgga gcttgacatc agtgtgacca acacggccat taacaatctg 410521 ccaagcgatg cggatattgt catcacccac aaagatttaa cagaccgcgc gaaagcaaag 410581 ctgccgaacg cgacgcacat atcagtggat aacttcttaa acagcccgaa atacgacgag 410641 ctgattgaaa agctgaaaaa gtaatcttat agaaagagag tgattgtcat gcaagtactc 410701 gcaaaggaaa acattaaact caatcaaacg gtatcatcaa aagaagaggc tatcaaattg 410761 gcaggccaga cgctgattga caacggctac gtgacagagg attacattag caaaatgttt 410821 gaacgtgaag aaacgtcttc tacgtttatg gggaatttca ttgccattcc acacggcaca 410881 gaagaagcga aaagcgaggt gcttcactca ggaatttcaa tcatacagat tccagagggc 410941 gttgagtacg gagaaggcaa cacggcaaaa gtggtattcg gcattgcggg taaaaataat 411001 gagcatttag acattttgtc taacatcgcc attatctgtt cagaagaaga aaacattgaa 411061 cgcctgatct ccgctaaaag cgaagaagat ttgatcgcca ttttcaacga ggtgaactga 411121 catgatcgcc ttacatttcg gtgcgggaaa tatcgggaga ggatttatcg gcgcgctgct 411181 tcaccactcc ggctatgatg tggtgtttgc ggatgtgaac gaaacgatgg tcagcctcct 411241 caatgaaaaa aaagaataca cagtggaact ggcggaagag ggacgttcat cggagatcat 411301 tggcccggtg agcgctatta acagcggcag tcagaccgag gagctgtacc ggctgatgaa 411361 tgaggcggcg ctcatcacaa cagctgtcgg cccgaatgtg ctgaagctga ttgccccgtc 411421 tatcgcagaa ggtttaagac gaagaaatac tgcaaacaca ctgaatatca ttgcctgcga 411481 aaatatgatt ggcggaagca gcttcttaaa gaaagaaata tacagccatt taacggaagc 411541 agagcagaaa tccgtcagtg aaacggtagg ttttccgaat tctgccgttg accggatcgt 411601 cccgattcag catcatgaag acccgctgaa agtatcggtt gaaccatttt tcgaatgggt 411661 cattgatgaa tcaggcttta aagggaaaac accagtcata aacggcgcac tgtttgttga 411721 tgatttaacg ccgtacatcg aacggaagct gtttacggtc aataccggac acgcggtcac 411781 agcgtatgtc ggctatcagc gcggactcaa aacggtcaaa gaagcaattg atcatccgga 411841 aatccgccgt gttgttcatt cggcgctgct tgaaactggt gactatctcg tcaaatcgta 411901 tggctttaag caaactgaac acgaacaata tatcaaaaaa atcatcggtc gctttgaaaa 411961 tcctttcatt tcggacgatg tgacccgcgt agcgaggtca cctctcagaa aactgggaga 412021 aaatgataga cttgtaggcc cggcaaagaa aataaaagaa ccgaatgcac tggctgaagg 412081 aattgccgca gcactgcgct tcgatttcac cggtgaccct gaagcggttg aactgcaagc 412141 gctgatcgaa gaaaaaggat acagcggcgt acttcaagag gtgtgcggca ttcagtccca 412201 tgaaccgttg cacgccatca ttttaaagaa acttaatcaa taaccgacca cccgtgacac 412261 aatgtcacgg gcttttttta ctatctcgca atctagtata atagaaagcg cttacgataa 412321 caggggaagg agaatgacga tgaaacaatt tgagattgcg gcaataccgg gagacggagt 412381 aggaaaagag gttgtagcgg ctgctgagaa agtgcttcat acagcggctg aggtacacgg 412441 aggtttgtca ttctcattca cagcttttcc atggagctgt gattattact tggagcacgg 412501 caaaatgatg cccgaagatg gaatacatac gcttactcaa tttgaagcag tttttttggg 412561 agctgtcgga aatccgaagc tggttcccga tcatatatcg ttatgggggc tgctgctgaa 412621 aatccggagg gagcttgagc tttccattaa tatgagaccc gccaaacaaa tggcaggcat 412681 tacgtcgccg cttctgcatc caaatgattt tgacttcgtg gtgattcgcg agaacagtga 412741 aggtgaatac agtgaagttg gcgggcgcat tcacagaggc gatgatgaaa tcgccatcca 412801 gaatgccgtg tttacgagaa aagcgacaga acgtgtcatg cgctttgcct tcgaattggc 412861 gaaaaaacgg cgcagccatg tgacaagcgc cacaaagtct aacggcattt atcacgcgat 412921 gccgttttgg gatgaagtct ttcagcagac agccgctgat tatagcggaa tcgaaacatc 412981 atctcagcat attgatgcgc tggccgcttt ttttgtgacg cgtccggaaa cgtttgatgt 413041 cattgtggcg agcaacttgt tcggtgatat tttaaccgac atcagctcaa gcctgatggg 413101 aagcatcggc attgcgcctt ctgcgaacat caatccatcc ggcaaatatc cgtccatgtt 413161 tgaaccggtt cacggctcag ctcctgacat tgccggacag ggccttgcca atccgatcgg 413221 ccagatttgg acagcgaagc tgatgctcga ccacttcgga gaggaagaat tgggggcgaa 413281 aattctggat gtaatggagc aagtgactgc cgacggcatc aaaacacgcg acattggggg 413341 acaaagcaca acggctgagg tcactgatga aatctgttcg cgcttaagaa agctctgatg 413401 aatcaggccg gtggcagatg gctgccccgg cctgtccatt tccttacgaa aatttccacg 413461 aaagtctaac caagcagatc caaatgctgt ataataattt ggaattctta ggaaagcatc 413521 gggtgaagga agttgaatgc aaaaacaatc acgttaaaga aaaaaagaaa aatcaaaacg 413581 atcgttgtac tcagtatcat tatgatcgca gctctcattt ttacgatcag attggtgttt 413641 tacaagcctt ttcttattga aggatcatca atggccccaa cgcttaaaga ctcagaaaga 413701 attctggttg ataaagcagt caaatggact ggcgggtttc acagaggaga catcatagtc 413761 attcatgaca aaaagagcgg ccgctcattt gtcaaacgtt taatcggttt gcctggtgac 413821 agcattaaaa tgaaaaatga tcagctatac ataaatgata aaaaggtgga agaaccatac 413881 ttaaaggaat ataaacagga ggtcaaagag tcgggtgtaa ccttaacagg tgacttcgaa 413941 gttgaggttc cttccggtaa atattttgtg atgggagata accgtctcaa ttcactggat 414001 agcagaaacg gaatgggcat gccttctgag gacgatatca tcggtactga atctctcgtc 414061 ttttatccat tcggtgagat gagacaggca aaataaaatg caatgcaaaa agaacatgga 414121 acatgacggc accgataata aagcgccgtg cacgtttaaa aaaatgatga tgaaacggtg 414181 cggagccggc tttccgcccc gttttttatg atagaaagcg ttttgaagaa aagggccctg 414241 ttgaaataaa cagaatcagg attggcgaag ccgtgaagcg catcgaattg gtaaatctca 414301 agatgggtat gctgtttttc ccgcagtttt ttgataagaa gcgctacgtc aaacgacggc 414361 tcataattag ggaaaaacaa taggaccggg caggctggca tgtgatgaag agagtcgcgt 414421 atccgggaac cgtaataaca aaccgatccg ctcacctcag gcatactgct gcatttccat 414481 gcgatagtag cccccacgct gaatccaatc acaaagatgt gccgtccggc gttttgcctg 414541 atcacattct ggatgatggt ttctcccgtt ttcagccttt cgtgttttgt aaattgttcg 414601 tatgccgttt tttcttcttt cagtgtgtag acttcatcct cgccgagcag gttgggcgtc 414661 aacacatcat atccagccat tttgatcagc cggcccatct ttttcatatg gctgtttaca 414721 ccatatattt cgtgtgcgag aatgacaagc ggttttggga acataacggc ctccttttgt 414781 gttttttcca ttatatccta tcgtttcact ttaggctgag atataatggt caaaaaaagg 414841 agatataaaa tgaactcatt atctttgcct caccgctatc catttttgtt tattgatggc 414901 gtgacggata gcgagcccgg caaacatgcg gcagcttata agctgattag tgagaacgac 414961 tggtttatca ctgatacgca aacagaaatg ccgttttcac ttgtgattga agcgcttgcg 415021 caaaccgcgg cttttacagg aattacagat gagaacagct tgggattatt gtcttcggtg 415081 aagaaagcgg aaaagctggg agaagctgtg cctggtgacc ggcttgatct tacgtttgaa 415141 gtcacgcgca atcggcgcgg gtttgtgttc ggacatgcca aggcatcagt tggagagcag 415201 cctgttgctg aagctgaaat cggcatctat attgaaaaat gaaaaaaacc cttcacaaca 415261 ttttgtgagg ggttctattt tgtgtcgtaa tcccgttcgc tttgagagtt atctctttgc 415321 tggcgtttgt gtttttcatc attcatattt tccttcagct cttcattagg aatcggatcg 415381 gttaagtcgt tgtgctcggg gttttcattt ggtttgtttt gctgtttttt ttctgtcatg 415441 tttgatcacc tcaccgtttg ttttcctctt attcattctc ctcaaacata ggaaatcgct 415501 tttttgtccc gctgggtata atgtattaga atagagagaa gcacaacaaa aagataaaga 415561 gaggtacata tatgtctgtt caaagagaag atgtagatat caagctgatc gcaattgata 415621 tggatggtac actgctgaac gacgagcagc tgatctcgga tgaaaaccgc aaagccattc 415681 gtgaagcgga ggataaaggt gtgtatgtgg tgatcagcac gggccggacg ctgatgacgt 415741 gcagggagct ggcggaatcg ctaaagctgt catcctttct aatcacggca aacggcagtg 415801 aaatttggga ttcgaatttt aatttggtgg aacggaagct gcttcatacg gaccatattc 415861 aaatgatgtg ggatttgcgg aataagcaca acactaattt ctgggcttct acggtgaata 415921 aagtatggag aggcgagttt ccggaaaaca ttacggatca tgaatggctc aaattcggct 415981 ttgacatcga ggatgacgat atccgaaacg aagtgcttga ggagctgaga aaaaacaaag 416041 agctcgaaat cacaaattca agtccgacaa acattgaagt caacgcgctt ggcatcaaca 416101 aagctgcagc ccttgccaag gttacggaaa aactcggctt tacaatggag aatgtgatgg 416161 cgatgggcga cagccttaat gacattgcga tgatcaaaga agcgggtctt ggcgtcgcaa 416221 tgggcaatgc gcaagacatc gtaaaagaaa cggctgatta tatcacggat acaaatattg 416281 aggatggtgt cgctaaagcg attcgccatt gggtactata aaaaaagaga gtcctaagat 416341 ggactctctt ttttagtttg gcaggtttta ttctgggacc atggtaggtt ttctgacaaa 416401 agtatttcac aaactgatat gattcactta taatgaaata aagttcaaaa attcggaata 416461 gtcgttccga atttcgggac aataaatgac ataaagcata tcgtttgctt tggcaggagg 416521 gattctgtgt ttcagattga tttaaactgt gatttaggag aaagcttcgg agcctacaag 416581 ataggccttg accaagatat tttagagtat gtgacatcag cgaatatcgc atgcggattt 416641 catgcaggag atcctagtgt tatgcgaaaa accgtcgcgc ttgcagcaga aagaggcgtg 416701 aaaatgggtg cgcatccggg cttgccggat ttactcggtt ttgggcgccg caatatggcg 416761 atttctcctg aggaagcgta tgatcttgtc gtttatcaaa ttggcgcgct ctctggcttt 416821 ctaaaagcag agggacttca catgcagcac gtcaagccgc atggcgcttt atacaatatg 416881 gcggcagtcg atcaaaaact gtcggatgct atcgcgaaag ctgtctataa ggttgatccc 416941 ggcctgattc ttttcggtct tgctgagagc gagcttgtaa aagcgggaga acggatcgga 417001 cttcagaccg caaatgaagt gttcgccgac agaacatacc aatcggacgg cacgctgaca 417061 ccgcgctccc agccggacgc actcattgaa agtgatgatg ccgccgtcac ccaggtcatc 417121 aaaatggtga aagaaggggc ggtcaaatct cagcaaggac atgatgtgtc attaaaagca 417181 gatacagtct gcattcatgg agatggagcc catgcgctga catttgcgca aaaaatcaga 417241 aaacagctca aagcggctgg aattgaagtg acagctattt cagaacagag gtcaacataa 417301 aggaggaaca atagatggag cagcagaaaa agacagcagg aaaaaaagcg ggcagctggt 417361 cattgctgat gggcgccgcc tttttaatgg cgacatcagc aatcggaccg ggtttcctca 417421 cccaaaccgc aacattcaca aacacactcg cagcaagctt cggttttgtc atcttaatct 417481 ctattatttt agatattttc gcccaaacca atgtgtggcg catcatcgca gtttctggaa 417541 aacgaggtca ggaaattgcg aatatggtgc ttcccggact ggggtatttc atcgccattc 417601 tcgtcgtgct tggcggacta gcttttaata ttgggaatat cggaggggcc gggctgggac 417661 ttcaggtgct gttcggcatt acacctgaaa caggcgcttt aatcagtgcc gttatcgcca 417721 ttttgatttt tgtcatcaag gaagcaggaa aagcgatgga ccgttttacg caaatcgcgg 417781 ggttcgtgat gattatttta acggtctacg ttgcggcgac gacagctcct ccggtcggac 417841 aggcagtcgc aaatacattc gtcccggaac acatcagcat atttgccatt gtcaccctag 417901 tgggcggaac cgtcggcggt tatatcacat ttgccggagg acaccgtttg cttgatgccg 417961 gaattaaagg aaaggaatcc attccgcagg tgacaaagag ctcggttgtc ggcattttaa 418021 ttacatctgt catgcgtatc gctctttttc ttgcggttct aggcgttgta tcgaaaggcc 418081 tgcacatcga tgaaagcaac ccggcggctt ctgtcttcaa gctggctgct ggaaatgtcg 418141 gttataaaat tttcggattg atcatgtggt ctgcggcgat tacgtctgtt attggagcag 418201 cctatacatc tgtttcattt tttaaaacct tttctccaaa aattgaaaag aattcacgcg 418261 gtattattat cggatttatt gtggtttcta cgttagcttt tgtcacaatc ggccagcctg 418321 cgaagatcct cgtccttgtc ggttcactga acggcttaat tctgccgatt gcgctcggaa 418381 cgctgcttgt tgccgcctac aagaaaaaca ttgtcggtga ttataagcat ccgctttggc 418441 tgacaagcac aggcgcgctt gtagtgattg taatggcagt tatgggaatc tacacgttat 418501 gtacacaact tcctcaattg tggagctgat ataagtggag caattaaaca aaatggcgcc 418561 aaaggatgta cgcgccctga tacgagaggg gaaaataaac gggccgaccg caggcatgtc 418621 cggcggctac gcccaagcga atcttgtggt tttgaaaaag gaccttgcgt ttgattttct 418681 gctgttttgc cagcgaaatc aaaagccctg ccccgtgctg gatgtgactg aagcaggttc 418741 gcctgtgccg tctctggctg cgccggatgc tgatatcaga acggactttc cgaaataccg 418801 tatttacagg cacggtatcc taacggaaga agtatctgat attacgccat actgggagga 418861 cgattttgtc ggctttctga tcggatgcag tttctccttt gaacaggcac tgatcaataa 418921 tgggatagct gtccggcata ttgatgaggg gacaaacgtc tcaatgtata aaacgaatat 418981 cgattgtgtt ccggcggggg cgtttcacgg acagatggtt gtcagcatga ggccggttcc 419041 tgaacggctg gctgtacgtg ctgcacaagt gacctcgcgt tttccggctg tgcacggagg 419101 gccgatccat attggcaatc cgggagcaat cgggattcgc gatctcggga aaccggattt 419161 cggagatgcc gtttccattc gtgacggcga ggttcctgtt ttttgggcat gcggagtgac 419221 cccgcaagcc gtggctatga atgtaaagcc tgaaatggtc atcacacatg cgccggggca 419281 tatgctcatc acagatattc gagacgagtc gcttgcggtg ctgtagcctc tcgtcatcct 419341 gatgaacgag aattaaaaga ggtgagaaag atgactgtac gatatcaaat cgaacagctc 419401 ggtgattctg caatgatgat ccgattcgga gaagaaatca atgaacaggt caacggcatt 419461 gtccatgcag cggccgctta tatagaagaa cagccatttc cgggattcat tgaatgtatc 419521 ccggctttta caagtctaac cgtattttat gatatgtatg aagtgtacaa gcatttgcct 419581 caaggcataa gctcaccttt tgagagtgtc aagcgcgatg tcgaagagcg gctggcagaa 419641 atagccgaag actatgaggt caaccgccgt attgtagaaa ttcccgtttg ctatggcggt 419701 gaattcggtc cggatttaga agaggtggcg aagatcaatc aactgtcacc ggaggaagta 419761 atcgacattc atacaaacgg tgaatatgtg gtgtatatgc ttggcttcgc gcccggtttt 419821 ccttttctag gcgggatgtc aaaacgcatt gcagctccga gaaaatcatc gccaagaccg 419881 tcgattcccg caggttcggt cggtattgcg ggattgcaga caggcgttta tccgatttca 419941 acgccgggcg gctggcagct gatcggcaaa acgccgctgg ctcttttccg gccgcaggaa 420001 aacccgccga cattgctgcg ggcgggagat attgtgaaat tcgttcgcat ctcagaaaaa 420061 gactatcacg cctataagga ggagtccaat tgagcatgaa agtattaaag cccggactgc 420121 tcacaacggt tcaggatata ggcagaacgg gttaccaaaa atacggcgtt ctggccagcg 420181 gcgctatgga cacggtttca ctgcgcattg ccaatctgtt gataggaaac ggcgaaaatg 420241 aagcaggtct cgaaataacg atgatggggc ccggtccgtc gtttcatttt tcaaaacaga 420301 cactgattgc tgtgacaggg gcggacttca cgctgcgtat taatgacgag gaagcgcctt 420361 tatggaagcc tgtgctcatc aaggaaaaca gcacggtcag ctttggcccc tgcaaactcg 420421 gcagccgtgc ttatttggcg gcagctggcg gcattgaggt gcctgccgtc atggaaagta 420481 aaagcacata cgtcagagga agcattggcg gacttcatgg cagagcgctt caaaaagaag 420541 atgaactgaa cattggagag atgtcagctc tttcgcaaac catcctttct cgcttaagtt 420601 cgcagcttgg aaaacaggga tttgcagcac cgaagtggtc agtcagccgc ggcagatttc 420661 tgccattgaa gaagaatccc gtcattcggg tgctggaagg aaagcaattt gcctttttca 420721 cagaagaatc aaaaacgcgt ttttatgaag aagcatttcg tgtcacgccg cagtccgacc 420781 gtatgggcta caggctcaaa ggagaaccgc tcgaactgaa ggccccgctt gagatggtgt 420841 cggaagcggt ttcattcgga acagttcagg tgccgcctga cggcaacccg attatcctgc 420901 ttgcagaccg gcagacgact ggcggctatc cgaggatcgc gcacatcata tccgctgatc 420961 ttccgattgt ttcccaaatc atgccgggcg agcacgttca gtttgagcct gtgtccctcc 421021 aggaggcaga agcgcttgcg gtagaacggg aacagcatat aaaagaactg aaaacgagaa 421081 tgaagatgga atggctgaca tagcaaaggg gatgaatgat gcagaataaa aataaaaccg 421141 tagtcaaatc tatggcgctg cttaatttgt ttttgcataa accaagccta accttaagtg 421201 aactggtgtc gctgacggga atgccgaaga cctctgttca ccggatggtc agctccttgg 421261 aggaaatggg gttcctcagt cgggatgcgt ccggcgctta ttcgctggga ttggtgtttt 421321 tggaattcgg acagcttgtc gctgacaggc tggatatcag aaaaatagcg aaaccggtga 421381 tggaagagct gtgccgggaa gtggatgagg ccgtgcagtt gatcatgagg gacggcaatg 421441 aagcgatata cgttgagaaa atagaaggga cacagactgt gcggctgtat acggcgatcg 421501 gcaggcgttc ccccctatac gcgggagcgt gcgccagaag cattctgtcc tttcttcccc 421561 gtgaagaaat cgaagcatac atcaaacaaa ccgagctcat ttcgattggc tccggaacga 421621 ttaccgatcc cgaaaaactg cttcaggaga ttgatgcctc tgtgcaaaat ggctatactg 421681 tcagctattc agagctcgaa aactatacgg cggcgatcgg cgccccgatc tttaaccatg 421741 agcgccaggt ggcagccggc attagcattg caggctttga agcgagattt acagaagaca 421801 ggctgcccta tttaacagaa aaggtgaagg acgccgcttt acagatttca agaaaaatag 421861 gatatacata agtagccaat cttttctctg ctgcgtacat taacgtatcg acgttcaaga 421921 gtggaggaaa gaacatggtg cttcgatata cagctctggg cgattccttg acgacaggga 421981 gaggctccgg gctgttttca cccggcttcg tccagcgttt tggggacatg atggaagctg 422041 acttgaaaac aagaacggca ataaacatat ttgccagatc aggtctgaat acagaagaga 422101 ttttgggact cctgtcatat ccctatgtgc aaaaatgtat tcgagatgct gatatgataa 422161 cgatcacagg gtgcggaaac gatctcatcg attcggtctt agcctaccaa acctctaagg 422221 atgaaacgat tttcagccgt gtatccgccc attgccatga gaattttgaa aagatgattg 422281 ccaaagtcgc cgagattaaa ggagaaaatc cttccccgta cgccattcgt gtgttcaact 422341 tatacaatcc gtttcccgaa attgatatcg ccggcaaatg gatcacttcg tttaattcac 422401 atttagaaac acttgcatca gcaccccatg tcaaaatcgc ggatgcctat agcatcttca 422461 aaggcaaaga acaggaatat ctgtcctttg acggtgtcca tccgaacagc aaaggctatc 422521 aagcgatggc tgaagccgtt cacaagctag gctataaaga attatcagtt tcatagaaaa 422581 cgcgcctcat gacaggcgcg ttttttatgt gtgatcgaaa tattaaaaga aacttaaaat 422641 tctctgtctt ctgttctaca gacaaacaaa gtgcgctaga ataatggagg gcgtaggcaa 422701 atatagccat aacgttcaat atttcgtata taaggaagga tggtcctttt gtttcggatt 422761 tttaaaatgt cttttgcggt tatcattatt atactggcgc ttattgcttt taactatacg 422821 gaacacacct ctgtaatcca atcggtcatg ctcgtctttc ttggtgcggt catgtttatg 422881 caggggcttg aagagcgcaa aaaagaaaat gacggctcag gcgcttttaa tatttatacc 422941 gccgtttttg tatggtctgt ctcccttatc ggttttacac ttcatattat ataaatctat 423001 tacacatcct gaaaatgctc gaccgtcggg aacggggtat agaaccgatg aagcaaggct 423061 ttccactctt gatactctga agaaccgcga aagccttccg tatggtcctc aagtgtttcc 423121 cactccacaa gaagcagata tttatgcgtt tcctccatgc attttgataa cgagtgagtg 423181 atatagccct tcatgccgga aataatcggc gcagcttgcc ggaatgcatc ctcaaactct 423241 tgttcaaggc cttctttaat gtgaagcatt gctgcctctc tgaccatgct atcccttctt 423301 tctgtctttt caaatagtct acagcaaacg ataggagatt tctgcaaaat cggtgaactt 423361 ttccttcatt ttcaaaaaaa tcttgcacgc accaattcaa ttaagagaaa ataacaagtg 423421 gaaggcaggg gaaagtcatg ttaaaaaagt gtattctact agtatttcta tgcgtcggat 423481 tgattgggtt aatcggatgc tccaaaacag attcaccaga ggatcgcatg gaagcattcg 423541 tgaaacagtg gaacgatcag caattcgatg acatgtatca aagcctgact aaagatgtca 423601 aaaaagaaat ctccaaaaaa gatttcgtca acaggtataa agccatctat gagcaggccg 423661 gcgtaaaaaa tttgaaagtc actgcgggag aagtagataa ggacgatcaa gacaacaaga 423721 cgatgaaaca tatcccgtat aaagtcagca tgaacacaaa tgccggcaaa gtcagcttca 423781 agaatactgc tgtgctgaaa ttagaaaaaa cagatgacga ggagtcatgg aatatagatt 423841 gggacccatc gtttattttc aagcagctgg ctgacgacaa aaccgtgcaa attatgagca 423901 ttgaaccgaa acgaggccaa atttacgata aaaatggaaa aggcttagcc gtcaatacag 423961 atgttccgga aattggaatt gttcccggag agcttggcga taaaaaagag aaagtcataa 424021 aagaactcgc caaaaaactt gatttgactg aagacgacat caagaaaaag ctggatcaag 424081 gctgggtaaa agacgattcg tttgtgccgc tcaaaaaggt caagcctgac caggagaaat 424141 tagtttctga agcgacgtca ttacaaggcg taacaagaac gaatgtcagc tcccgctact 424201 atccgtatgg cgaaaagaca gcccatttga caggctatgt ccgcgccatt acagcggaag 424261 aactgaagaa aaagaaagaa ggaacgtaca gcgatacgtc taacatcggt atcgccggac 424321 ttgaaaatgt gtatgaagac aagctaagag gcacaactgg ctggaaaatc tacgtgccgc 424381 aaaccgggga agtcatcgct gaaaagaaag caaaggacgg cgaggatctt cacctcacaa 424441 ttgatatcaa aacgcaaatg aagctgtatg atgaactgaa ggatgacagc ggggcggcag 424501 tcgcgctgca gccgaagaca ggcgaaacac tcgcccttgt cagcgcgcct tcctacgatc 424561 caaacggatt tattttcggc tggagcgata aggaatggaa aaagctaaac aaagataaaa 424621 acaatccgtt ttcagcgaaa ttcaataaga catacgcgcc aggttctacc attaaaccga 424681 ttgcggctgc tattggaatc aaaaacggca cccttaaagc cgatgagaag aaaacaatca 424741 aaggcaagga gtggcaaaaa gattcaagct ggggcggcta ttcagtgaca cgtgtgtctg 424801 agagacttca acaagtcgat ttggaaaacg cccttattac gtcagacaat atttattttg 424861 cccagaatgc gcttgatatg ggagcggaca cctttacaaa aggcttgaag acattcggtt 424921 tttcagagga cgttccgtac gaattcccga tccagaaatc gtctattgca aatgacaagc 424981 ttgattcaga cattttgctt gcggatacag gctacggaca agggcaaatg caaatgtctc 425041 cgcttcactt ggcaactgct tacacgccat ttgttgacaa tggagacctt gtcaaaccga 425101 cgctgatcaa aaaagattca caaacagctg atgtttggca caagcaagtg gtcacgaagg 425161 aaggagcggc agacattaca aaaggtctga aaggcgttgt ggaagatgag cgcggatcag 425221 cgtatcagcc tgtcgtgaaa ggaatcacag tggctggaaa aacaggaaca gccgagctga 425281 aaacatcaaa agatgataaa gacggcacgg aaaatggctg gtttgtcggc tacgattacg 425341 aaaacaaaga cctgcttgtc gccatgatga tccaaaatgt gcaggaccgc ggcggcagcc 425401 actatgtcgt tgagaaagcg aaaaagcaat ttcaatcgaa ttaaaatgtc tttttaaaag 425461 gagcgaaagg aaaaagggga tctgaggccg aatgaactag taagggggca aaacccggtt 425521 tatacaaaga aaagagggat tttgcatgca gcgtattcaa ttggcggagg atcttcaatt 425581 ttcaagagtc atacacgggc tttggcggct gaatgaatgg aactattcag atgctgaact 425641 tctaagcctc attgaatggt gtatcgatca cggcatcacg acctttgatc atgcggatat 425701 ttatggaggc tatacgtgcg aaaagctgtt tggaaacgcc cttgcccttt cgcctggatt 425761 aagagaaaac atagagttgg tcacaaaatg cggtatcgtt cttgaatcgc ctgaacggcc 425821 cgctcacaga tcgcatcatt ataacacaag caaatcgcat attttggcat ccgttgagca 425881 atcgcttatg aaccttagga cggattatat cgatatgctt ttgattcaca gaccggaccc 425941 gctcatggat ccggaggggg tagcagaggc gtttcaggcc ttgaaatgct ctggcaaggt 426001 caggtacttt ggcgtttcaa attttaaaga tcaccagtat cggatgctgg aatcatattt 426061 gcctgagaag ctcgtaacca accagattga gctttccgca tacgaattag aaaatatgct 426121 cgacggcact ttgaacctgt gccaggaaaa acggattccg ccgatggctt ggtcgcctct 426181 ggcaggcggc aaagtattca ctgaaaacac ggataaagac cgacgtgtcc gtacggcgct 426241 tgaatccgtc caaggggaaa tcggcgccgc ttcattggac gaggtgatgt acgcatggct 426301 gtatacgcat ccggccggca tcatgccgat tgtcggaagc ggaaagcgcg agcggatttc 426361 cgccgcgata aatgcgttgt catacaagct tgaccaggat caatggttcc gcatttttac 426421 agccgtacag ggttacgata ttccataaaa agcatcagtt taccagctga tgctttttca 426481 atattgtcac accgcttagt gccaaattac catttataag tgattgattc tttcttgaaa 426541 gcgttttata ttaaaaggaa acctctctat atcctctact gcatctcctt gcgacttcat 426601 ccgcacatca agattggcta ggaggtcttt tttatgtata tgactgccag agaacaaaag 426661 ctgttaaagc acttattatt acaaaacaga tatataaccg taactgagct tgctgagctg 426721 atgcaagtca gcacgagaac cattcacagg gaactcaaat caattaaacc gctgatggaa 426781 accgtggggc ttacgttaga taaacagccc ggtaaagggt tgaaagcagt gggaagtccc 426841 gagggtaaac aaaagctgct tactgattta tcatatgaac agcatgaata cagcgccgac 426901 gaacggaaac tgctcattct ttgttcgtta ttagagtctc aggagcccgt caaactgtac 426961 acgcttgctc atgatctcca ggtgacgaat gccacggtca gctatgactt agatgagctc 427021 gagaagtgga tttctccctt tggactgaca ctgatccgca aaagaggttt tggcatccag 427081 ctcatagggc cggagaatgc gaaacggaaa attgtcggca acttgattgt gaaccgtctc 427141 gacatccaaa tgtttttgga agcggttgaa ttaaacatca aaggaaaaac cgattcttca 427201 gagaaaatgt tcggggttgt cagcaaaggt gagctgttaa aaatggagcg catcttattt 427261 cagctcaaag aaaaaatcgc tttttcattg tccgacagct cctatatagc gctcgtcgtc 427321 catctgacgt atgcgatcga acgaattaag cttggggaaa ctatcaccat ggagcaaaat 427381 gagcttgagg aactgatgaa tgcgaaggaa tacagctccg ctcttgaaat cgcgggcgag 427441 cttgaacgtg ccttcggcgt gacgattcca gaggcggagg tcggctatat tacaatccat 427501 cttcgaagcg ccaatcgaaa atacaaaaca gaatacaaag cgcaggaaat tgagctggaa 427561 acagccctgc aaacaaagcg gctcattgct tttatttcag acaaaatcag aatggatctg 427621 acgaaaaact actctttata tgaaggcttg attgcccatt tggagccggc cgtcagccgc 427681 ataaaagaaa atattgagat atacaatccg atgaaggaac agatcaagcg cgattatttt 427741 ctgctttata tggcgatcga agaaggtgtc gaaaagtatt ttccgggcat gtccttttct 427801 gatgatgaaa tcgcttttat cgttcttcac tttggctcgg ctcttgaaat caaaaaagaa 427861 gaagcaaaag tgaaagcgct tgtcgtctgc tcaagcggga tcggctcctc gaaaatgctt 427921 gcctccagac tgaaaaaaga gctgccggaa attgaatcgt ttgatatgtc atctctgatc 427981 gagctaaagg ggaaggatgt tcaagcctat gatatgattg tgtccactgt accgattcct 428041 tatgaaaaca ttgattacat catggtcagc ccactattaa atgaggaaga cgcaaaccag 428101 gtcaagcagt atatcaagcg gaagattccc cttattctta acaaaaaaag aagctcgaag 428161 gaagaggcgc agcaagctga tgtacctgac atgctggagg cggcggaaag catagggcgg 428221 tatatggaag ttatccaaga tgttctgcgc cattttacgc tagctcaact caaaacaaac 428281 ccggaccata gcatgcttct gctagagctt tttcaacagc tgaagaagga tggcctgatc 428341 cgtgatccgg aaaaagccgc ggtttgcctg gctgagcggg agaaacaagg gggattggga 428401 atccccggaa caaacatggc gctttatcat ctcaaaaatg atgaaatcgt cctgcctttt 428461 ttcaaaatgt ttgatctcag caccccctat gaagtggatg gcatggacgg aaataccctc 428521 aggatgacac gcattctcgt catgatggcg cctggctcat tatctgctga aggctcggag 428581 attttaagcg cgatcagctc ggcaattatc gagagcggag aaagcatggc ggggtttcag 428641 gaagaaggag gacaagaatt gtatcagcgg ttaaaccgca tatttttcac atggatgaaa 428701 gaaaaaaaca tactgtaaac ctgcatggca cacgtcaaaa atttggcgtg tgtttttctg 428761 tggatgggga acaaaataag aaaatgtggg actattttat cattcagtat tggaataatt 428821 ccaaaatgaa atagttttac aagttatctt ttttgggtta aaatgggtga ggtaaggaag 428881 aaaatctaac aaattattga agattcaaga gaatatagga gatgacgata tggaaacatt 428941 acagcatctg attctgcatg acatgccgaa tagcgaagaa atagaggctg taaaaagcgg 429001 agaccataca ctgacatata aaggttaccg taaacggatt aatcagctgg cgaatgccat 429061 gcttcaaaaa ggaattcaaa agggcgaccg tgttgcattg ctttgcaaaa acggccatcc 429121 cgcctcaact gttatgttcg ccgcacttga aataggtgct gttgtcgtac ctgtcagctg 429181 gcagctgaaa ccatatgaaa tgacaggcat tttaaaagca agtgaaccaa aagcgatgtt 429241 ttacggagcg gagtttaaag agatactgga tgaagttctt cctgaattgt cctcactgtg 429301 tgtaacaatg gaaacaggaa cagcttacga aacatctgct gaatttgaag cgctgtttgc 429361 aggtcctgat catttgccag agacggaaat ggtttcacct gatgatacag cacttctgat 429421 gtttacatct ggaacaacgg gaaacccgaa aagatgcatg attacacatg gcggcatata 429481 cagatacgtt aaaaaatcca acagctcaat agcacgtatg aagggccttc gttttctcgc 429541 gtgccatccg atttatcata cgagtgcgct catttgcatc atgcttggaa cgtttgcaga 429601 aacaacattt gtgtttacaa aggatcaaga tcctgttcac atgctgaagg tcattgaaga 429661 agagaagatt cagaccgtga tggctcttcc tgtgttctac acgtatttgc ttgaggcgtg 429721 ggaaaagcac caaactgact tatcttcgct tgttatttta atgacaggcg gaacaaaagt 429781 gccgagcagc ctaataagcc gctatcttga tattggcatt ccgcttgcgc atggctatgg 429841 aagtactgag gcttggggca tcagcacatg gacgcctgat atgggaatgg ataaagcggc 429901 atctgcagga aaacctgtgg caggtgttaa agtcaaagtg gaagatcctc tgaccggaga 429961 agaacttcct caaggagaaa tcggcgaaat cgttgttcat actccattct tatttaaagg 430021 ctatgaagac aatcctgaag caacagcgaa agtgctgcaa aatggatggt ttagaaccgg 430081 agattcagga tatgtagatg aagatggctt tattttcatc acgggacgct acaaggatgt 430141 cattatttac ggaggcgata acgtctatcc tgatcaggtt gaagaagtta tccagcagat 430201 cccgggaatc cttgaaacgg ctgtggtcgg tattcctgac ccgctttacg gtgaaaaacc 430261 gaaagctttt atcgtgaaaa atggcggcca gcgcatcacg gaagaggatg tcatcgcatt 430321 ttgtaaagaa cgcctgtccg cttacaaaat acctgaagtt gaatttgtta acgaactgcc 430381 gaaaaacaac cttggcaagg tgaaaaaaga cgtcctgcgc aatcaggctg tacattcata 430441 aaagaagaag cccgtccact ttatgtggcg ggcttctttg cagttgcaca gacggaaagc 430501 tcaggcttaa tgttcttaaa ttgtatatca atgtcttcga agccggctgc tttaaagtca 430561 gcaatcatct gtcttccaaa tgatttggtt ttctcaggac tggcatccgc ttcccgcggc 430621 tgcatcgtaa tggctgcttt gccgcctggc tttaatgccc gataaatctg ttttatgcct 430681 tttgtttggt cattccaaat ggtgtagttg ttaacggaaa tcactttatc ataaaacgag 430741 gcggggagag gaaatgtctc gatgcttcct tgtatcaggc gtacgccctt tggtttcact 430801 ctgcgggcgg ccagcttcag catggcctct gatacatcaa tcccatgaag atgaacatcc 430861 ttctcgcgtt tcagcatctg ctgcatgcag tatcccgggc caaacccgac ttctaaaatg 430921 ctgtccccgc gcgtgatacc cagctgattg attgtccact gattcagtgt ttgattttca 430981 gcagccatga tgtacccggc aatcatgccg atgacgccct ttggcctgct gaatcttcta 431041 gaaagcatgt taatcattca gcaaccaacc ccctttttga gttaatttcc tctcagcgtt 431101 ccatgtgaaa catttttctg ataaagcaat gcgaaggtgc caagccatgt ttatccaaag 431161 agtgtgtgag gtacacaaca aatagacatg aaaacaaagg aggagaatca tcatggcaaa 431221 ttatccaaaa gaactgccgg cacaaactca aagtcgccag ccgggaattg aaagcgaaat 431281 gaatccaagt ccggtgtatg agtacgagga ttataaagga gcagacaaat taaaaggaaa 431341 agtagctctt attacaggcg gcgacagcgg gatcggacgc gcggtttccg tcgcttacgc 431401 aaaggaaggc gcagacatcg ccattgtgta taaggatgag catgaagacg ctgaggagac 431461 gaagaaacgt gttgaacaag aaggcgtaaa atgcctgctg attgctggtg acgtaggtga 431521 agaggaattc tgcaatgaag cggttgaaaa aacggtcaag gaactaggcg gccttgacat 431581 ccttgtcaac aatgcaggtg aacagcaccc gaaggaaagc atcaaagata ttacgagcga 431641 acagcttcac cgcacattca aaacaaattt ttattctcaa ttttatttga ctaaaaaagc 431701 aattgattac ctgaaaccgg gcagcgccat catcaatacg acatccatca acccgtacgt 431761 agggaacccg acactgattg attatacagc gacaaaaggg gcgatcaatg cctttacaag 431821 aacaatggcg caggcgcttg tcaaagacgg catccgtgta aatgcagtcg cgccgggtcc 431881 aatttggacg ccactaatcc cagctacgtt ccctgaagaa acagttgctc aatttgggca 431941 agatacgccg atgggccgtc ctggacagcc tgttgagcac gtcggctgtt atgtgcttct 432001 ggcatcagat gagtcctctt acatgacagg tcagaccctg catgtcaacg gcggaaactt 432061 tgtgacgaca taagagggag tgagacatat gggcatcacg aaagaagaag tgaacagcta 432121 ctatcaaaaa gcagggattg tattaacgga cgaggaagta gaccaaatcc agctgatgga 432181 ttacggctta ggaaaagaaa gaaaagtcgg gctccagctc ttcgtctacg tcaatacaga 432241 ccgttattgt tcaaaggaat tggtgctgtt tccgggacag acttgcccgg aacaccgcca 432301 tccaccggtc gacggccagg aaggcaagca ggagaccttc cgctgccgct acggaaaagt 432361 gtatctttac gtagaaggag aaaaaacgcc gcttccaaaa gttctccctc ctcaggaaga 432421 cagagaacac tatacggtct ggcacgaaat tgagctagaa ccgggcgggc aatacacgat 432481 tccaccaaac acaaagcatt ggttccaggc cggggaagaa ggtgccgtcg tgacggaaat 432541 gtcatcgacg agcacggata aacatgatat ctttaccgat ccaagaatat aaggatgggc 432601 ttaacagccc atcctttttg tattgaaaaa aacagaatca tcgctataat gggtaaaaaa 432661 ggaaagaggg cgaggcaatg ttcacttgca aggtaaatga gcacatcacc atccgattat 432721 tggagccgaa ggatgcggag cggctggccg aactcattat ccaaaatcag cagcggcttg 432781 gcaagtggct gttttttgcg gaaaatccaa gcagcgctga cacgtaccga gaaacaatca 432841 ttccagattg gcggcgccag tatgccgacc tgaacggcat tgaggcgggt ctcctttatg 432901 acggcagcct atgcggcatg atcagcctgc ataaccttga tcaagtgaat cgtaaggcgg 432961 aaatcggata ttggattgcc aaagaatttg aagggaaagg cattattaca gctgcctgcc 433021 gaaaactcat tacgtatgct tttgaagagc ttgagctgaa tcgtgtggcg atctgtgcgg 433081 ctgtcggaaa cgaaaaaagc agagcggttc cggagcggat cgggtttcta gaggaaggaa 433141 aggcacggga tggcttatac gtaaacggca tgcatcacga cctcgtctac tacagtctgt 433201 taaagcgtga atgggaaggc gaaaaataaa gagcacactt tcttgtttaa atcttccccg 433261 gatgtggaaa agtaacagcg gagacgttaa aaaggagtga ttcgagatga atcagcaaga 433321 cattaaacaa aaagtgcttg atgttctaga tcaccataaa gtaggttcgc tcgcaacagt 433381 tcaaaagggc aaaccgcatt cccgctacat gacttttttc catgacgggc tgacgattta 433441 cacaccgaca agcaaggaaa ctcataaagc ggaagaaatt gagaacaacc ccaatgtcca 433501 cattttatta ggctatgatt gtgaaggttt tggcgacgca tatgtcgaag ttgccggaaa 433561 agcaaagatc aacaattcgg cagaactcaa ggacaaaata tggagttcca aattagagcg 433621 ctggtttgac ggcaaggatg atccgaatct ggtgattctt gaaattgaac cggaggatat 433681 cagattaatg aatgccgggg agaaaacacc ggtctcactc gaactataaa aaatttgtgt 433741 tttcaggggc gatatgttat tatgaatagc tagtaagaaa aataagcaaa taaaaaagaa 433801 agtaaacttc ttttttctgt tttgagagag aagcttaccg cttcccaagc agcataacca 433861 gctgccctta ttcttttcct tcataacaaa tcgcccctaa cgatgagatg gaaaaaagac 433921 ttttttgttt tacaattcac accggcgcgg cttcggagcc gcagtgacga ttgagaggta 433981 gggctttcgt tgtcttgtgt tcaagaaatt tccatggtgt ttactttcca gaatgattct 434041 tcggaacaat gctttatgaa tctaacccgc ctgacttggc ggatgatata atctttattt 434101 gcgtatagaa aagaataaga caaaccgccc ggcgtacgcc ggacggtttt tttattgcaa 434161 aaaacacatc gtactgaaac ctccttgtct tctttccagt cttatctcta ggatgaaatt 434221 ggaggaagaa taacgtgcat gtcattacaa cacaagtact ttttattttt tgttttttat 434281 tgctgattca ctcgatagaa accttagcct atgcgacaag gctttccgga gctcgcgttg 434341 gatttattgc gtccgcgctt tctctgttta atgtcatggt catcgtatcc agaatgtcga 434401 atatggtgca gcagcccttt actgggcatt taattgatga tgctggaaaa aacgcactgg 434461 cgattgtagg ggagcagttc cgctttttaa ttttcggatc gacagtcggc accattttgg 434521 gcattatcct gctcccgtct tttgtcgctc ttttttcacg ggcgattatt cacttggcgg 434581 gcggcggcgg ctccgttttt caagtattcc gaaagggatt ctcgaaacaa ggattcaaaa 434641 atgccctttc ctatttgcgt ctgccgtcca tttcatatgt aaaaggattt catatgcgct 434701 tgattccgaa gcgtttgttt gtcatcaaca tgctgatcac atcgatttat acgattggtg 434761 tgctttcggc tttatacgca ggccttttgg cgccggagcg cagcacgaca gccgtcatgg 434821 cttcgggttt gatcaacgga attgcaacga tgctgctggc tatttttgtt gatcctaagg 434881 tatccgttct tgctgatgat gtggcaaaag gaaaacgaag ctatatctat ttaaaatgga 434941 cctctgtcac aatggtcaca tcaagggtgg cgggcacact cctcgcccag ctcatgttta 435001 ttcccggggc ctactatatc gcgtggctga caaagtggtt ttaataagaa aggctggatc 435061 ataaagatcc agcctttttg cgcttcctta tttatagttc cttaatccgc ggtcgtacaa 435121 aaaatttccg aatgggacga aagcggcgat gaagccggca gctgaccatt tcagcggcca 435181 tttgacagag aaggttgcat aagccaagac aagcaaatac aaaatgaaca acccgccgtg 435241 aaccgaaccg acaattgtca ccgcaagcgg aaggcctgcc caatatttaa gcggcatagc 435301 gatgaacaac aggattaaga gtgacattcc ttcaataaaa cccatcgtgc gaagtcttcc 435361 gatcggcgtg tgcagcataa atcgccctcc ttgtggacac gttttcattt tatactataa 435421 acaatccggg ggggcatatg acagctttca aaaaatgttc ggaaaacatt catttttaca 435481 tgccttttct agggaactgt acttgtcatt tacaaaaata cccgagataa tgtgtacaaa 435541 atcaaaaaag aaggatgttg aaatgaaact tgaccagatt gatctgaata tcattgagga 435601 gctgaagaag gacagccgtt tgtcgatgag ggaattaggc agaaaaatta agctgtcgcc 435661 tccatctgta acagaacggg taagacagct tgaatcgttt ggcatcatca agcaatacac 435721 gctggaggtc gaccagaaaa aactggggct tcccgtttcc tgcattgtgg aagcaaccgt 435781 taaaaacgcg gattatgagc ggttcaaaag ctatattcaa acattgccga atattgaatt 435841 ttgctaccgg attgcgggtg cagcctgcta tatgctgaaa atcaatgccg aaagcctcga 435901 agcggtagaa gatttcatta acaaaacatc gccctacgcg caaaccgtca ctcacgtcat 435961 tttctcagaa attgacacga aaaacgggcg cggttagaga gtgccgcgcg aagtctgtta 436021 taataacagg atgagcgtga aagaaagaga agtgatcaag catgtcaaaa acagttgtat 436081 tagctgaaaa accttcagtc ggccgggatt tagcccgggt actgaagtgc cataaaaaag 436141 gaaacggtta tctcgaaggc gatcaatata ttgtgacttg ggctttaggc catttggtga 436201 cgcttgctga tccggaaggc tacggaaaag aatttcaatc atggcgccta gaggatctgc 436261 cgattatccc agaacccttg aagcttgtgg tgataaaaaa aaccggaaag cagttcaatg 436321 cagtcaaatc ccagcttacc cgtaaagacg tcaatcagat tgtcatcgcg actgacgcag 436381 gccgggaagg tgagcttgtt gcgcgctgga tcattgagaa agcgaatgtc cgaaaaccaa 436441 tcaagcggct gtggatttca tctgtgacgg ataaagcgat caaggaaggt tttcaaaagc 436501 tgcgcagcgg caaagaatat gaaaacctgt accattctgc cgtcgccaga gcggaagcgg 436561 attggattgt ggggatcaac gccacccgtg cacttaccac aaaattcaat gcccagctct 436621 catgcgggcg tgtgcagact ccgacgcttg ccatgattgc aaagcgcgag gcagacattc 436681 aggcgtttac gcccgttccg tattacggca tacgtgctgc agtcgacggc atgacgctga 436741 cgtggcagga taagaaatca aagcagacga gaacgttcaa tcaagatgta acaagccgtt 436801 tgctaaaaaa tctccaagga aagcaagcgg tcgtagctga gctgaaaaaa acagcgaaaa 436861 aaagctttgc gcctgcgctt tatgatttaa cggagctcca gcgtgacgcc cacaagcgct 436921 tcggtttttc tgccaaagaa acgctttctg tcctgcagaa gctatatgag cagcataagc 436981 tcgtcacata tccgcggacg gactctagat ttttatccag tgacatcgtc ccgacgttaa 437041 aagaccgtct ggaaggcatg gaagtaaaac cgtatgccca atatgtcagc caaattaaaa 437101 aacgcggcat taaatctcat aaaggatatg tcaatgacgc gaaggtgtca gaccaccacg 437161 cgattatccc gaccgaagag ccgctcgttc tcagcagtct gagtgataaa gaacgaaagc 437221 tgtatgacct gattgcgaaa cgtttcctgg ctgtattaat gcctgcattc gaatatgagg 437281 aaacaaaggt catcgcagaa atcggcggag aaacctttac ggcgaaaggc aaaaccgtgc 437341 agtcgcaagg gtggaaagcc gtttatgata tggcggaaga ggatgatgag caggaggatg 437401 acagagatca gacacttcct gcgcttcaaa aaggcgacac acttgccgtc cgcacgttaa 437461 cggaaacaag cggccaaacg aagccgcctg cccgctttaa tgaagggacc ttgctgtcag 437521 cgatggaaaa cccaagcgcg tttatgcagg gagaagaaaa aggcctcgtc aaaacgcttg 437581 gagaaacagg cggcctcggc acggtggcaa cgcgtgccga cattattgaa aaactgttca 437641 acagcttttt aatcgagaaa aaaggccaag atatttttat cacatctaaa ggaaaacagc 437701 tcctgcagct tgttccggag gatctgaaat caccggcctt aacagcagaa tgggagcaaa 437761 agctgtctgc gatcgcggcc ggcaaattga aatcggctgt ttttattaaa gatatgaagg 437821 cttacgctca ccaaacggta aaagaaatca aaaacagcag ccaaaccttc cgacatgaca 437881 acattacggg aacggcatgt ccggaatgcg gcaaaatgat gctgaaagta aacggcaaac 437941 gcgggacgat gctcgtgtgc caagatcgtg aatgcggaag cagaaaaacg attgcccgaa 438001 aaacaaacgc acgctgccca aattgccata aaagaatgga gcttcgcggc caaggcgagg 438061 gccaaacctt tgcgtgtgtg tgcggtcacc gtgaaaagct ctctgtattt gaaaaacgaa 438121 aaaacaaaga caaagcgcgt gctaccaaac gggacgtatc ctcttatatg aaaaaacaaa 438181 ataaagatga gccgattaac aacgcgctgg cagaacagct gaaaaaactc ggtttggata 438241 aataataaaa aaacctgtgc ctatcgcaca ggttttttat tggacttagg tcctgttttc 438301 ttaatgttca aaaagggaaa aaaaagctag caatctgcat tttttttctt ttatagtaaa 438361 tgtactttgt aacatggcag tcatattttc gtctataact atttgtgagc gtctgatttg 438421 cttcaggcga caaaggggga tttgcctgtg aggcatgtac taattgctgt catcttattc 438481 ttcttatcta tcggactttc cgcagggtgt gctgaagctg gaaacaagac ccaaaatcag 438541 tcggcgacag aagtgaatgc cagcccgctc cagccggcgg aatatttcat ctatcacaat 438601 ttaatgaatg acaaagggct gatcaaaacc gatttttcag accagccttc ttacttgtcg 438661 gaatctctcg gactgtggat ggagtttctg ctcagcaaaa atgacgcacc acatttccag 438721 gatcaatatc agcatctgac tgattcattt ctgatgagca atcacttggt gacgtggaag 438781 attcaaaatg gccaagcgag cgggacgaat gcgctgatag atgatatgag aattatgctg 438841 tctcttgacc aagccgccgc aaaatggggc cgcagcgact acgcgcaaac ggctagggat 438901 atcggcacgt ctttgaagac atacaatatg aacaacgggt tttttacaga cttttacgac 438961 tcacaggccg cttcaaagga tgtgacgctt tcatacgtca tgcctgatgc cttagctgtc 439021 ttaaagaaga atggaatcat agacgaagaa acagaacagc ggaatgccaa tgttctctat 439081 tcagctcctt taaaaaatgg ctttctgccg aagacataca gctcggagac gaaggaatac 439141 acatatgata gtgaaatcaa cctgattgat cagctttacg ctgcttggca tttgccggaa 439201 ggggatgaaa aagcatctgt tttagcggac tggatcaagc aggaatttca gaaaaacgga 439261 aagctgtacg ggcggtattc ggcatatacg aaggagcctg ccgtccaata tgagtctcca 439321 tccgtatatg ccttagccgt attgtttttg acaaaacagc atgaaaacag ttctgtcatc 439381 aaagccatat atgatagaat gaatgacttt gaaattcatg atccggtgaa atcgtattat 439441 ggaggctata tgagcggcac tcagacgcat tcatttgaca atctgctgcc gctgttagcc 439501 gaaaggaagc tttttaatga aaatatcatt cagtgaatca caaaaattat ttgcttattt 439561 ttcagggctc atcgcggccc tgtctttgtt tatttattat gtgtcagccc agcaatcaga 439621 aggtgctctg atcctttgca tcacatttgg cgtcatcgcc gcaggcatct ggttcggccc 439681 gatttacgcg ctggcagtga ccttaatcgt actctttgtt ctcggcacct taatgatgtt 439741 tttccagact ggacagacat cgctctttcc ggctgaggaa gggctgcgaa tgcttgtcgt 439801 gtggggaatc gcgcttttgc tgttttcttt tatttctgga agaatccacg atattacagc 439861 agagcttcgg cgctcaatga cacggcttca atccgaaatt aaaagctatg ttgctgttga 439921 cagagtgact ggttttgata acaagcaaag gatgaagctg gaactttcag aagaaatcaa 439981 gcgggcggag cgctacggca attcttttgt gtttttgctg ctccatatgc attatttcaa 440041 agagtttaag tctttgtacg gtgaaaaaga aacggaccgc ctcttccaat atgtcggtca 440101 gcaaatcagg acaagcgttc gggaaacgga taagaaattc cgtccctctg acgagcgtat 440161 cgggatcgtg ctgacgcaca cgcctgctga acatatgccg gccgttctga ctaagctgaa 440221 gaaacaattg gatacatatc agctggaaaa tggaaagtat gtgtcgctta cgttccacgt 440281 ttgctatttg ccctaccgca acgatatcca aacagctgat caatttttag aagaactgga 440341 aaacgagatg atgatgaatg aactataaag gaatcacatt gctatgcgtc atgatgcttc 440401 tattttcagc tattgcgtct tttcccgttt ctgcgcaagc gaaagatcag gatgccggca 440461 ttctcatcat ctactcaacc ttggacggca aagagtcgtc acaagtcaaa atgctcgatt 440521 tgcttgcggg ccactttaca tcccatgtga cagtcaaaaa agattcagac gttgaagcgt 440581 cggatttcaa agggaaagac catgtgattt attacggcca aacgaaaaga aagctcagcc 440641 aaaaattgct gtctcttatc agcggcgtga aaaaaccggt tgtcgccatt ggctataacg 440701 caggccaaat cagccaattt tctgggcttt cattagcccg caaagaaaat gtgtttcagg 440761 ttcacagcag gtcagaaaag gccgatgtgt ctctggaaag cgggcttaac gtgctgagtg 440821 tatcaggcct gaaaggaacg gcgctttaca ccttcaaagc ggatgaaggc acaacgcatt 440881 cttttatatg gaaaacaaaa aaagggaatg tgtacattgg attaacaaat ttgttaaatg 440941 acaatttgat cgtggcgaaa cagctcagag aagctttcgg agagaaggcg gggacgacgt 441001 tattgtattt gcgtctcgag gatatcagcc cgatgtctga tgaaaaactg ctgcttcaag 441061 ccggtacata cctgcataag cggcatattc cttttatcct ggcggtcatt ccggtttact 441121 tgaatccgga aacaggcgac aaagtgtatt tgtctaatca accgaagatg gtcaaggtgc 441181 tgaagaagct gcaaagcatg ggcggcagta tcatagttca cggctatact cacgcttatc 441241 gctacagtga aacaggagag ggatttgaat tttgggatgc aaaggcggat cagccgatta 441301 catccggaaa tgccgaagac cccccgtcca ttttggagaa agaacaggac ttcccgaacg 441361 aacaagccta tcacagctat cttgaaccat ttcgggaaaa ggaagaaacg tatacaaaac 441421 aaaaactgac gcgtgccatt gaggatttga catcatcggg tctttacccg ctggcgtttg 441481 aagcgccgca ttacacgatg tccgaatatg gctatcaaat cgcctcgcag tattttacaa 441541 gcattttcgg ccaggtccag ctcagcagca caacatggaa aacatccggt gcacctccgt 441601 ttgtgactgc tccttcgatg ctgcacggaa tgacgcttta tccggaaacg atcggctttg 441661 tcgacacatc gaagcaaaac ccgctcggtg agatggagga gcatatctcc cagatgattg 441721 attttgaagg cggagtagcc ggaggatttt atcacccgta ccttgggatg aaatatctgc 441781 ctgagctggt tgatcagatg gaacgcattc cagacagtga atggcttgat ttaaagaaaa 441841 cgaaacaaac cgtcaaaaca gacaaagtgg aaattcatac aagcggtgac ggaacgattc 441901 aggtgaaaaa cggcgtaagc cccatttacg agtttttcga tcatcaccgg caaacccctc 441961 tggaaaaggc gttatggatt ctctccgctg ttgtgctctt atttgtcatc atgtttgtca 442021 gttatacgtt ttacttgaga gccacattga aaaaacgaat ttttaaggag agaagaagcc 442081 ttgggtaata cgctgttctt tatctcgcta agtttaatat gggttatgct tctctaccac 442141 atgttcctca tgcagggcgg gtttcgccac tatatgacct tcgaacggaa tatcccgaag 442201 tggagagaaa atatgaagga actgccgaag gtcagcgtcc tcatcccggc gcataacgaa 442261 gaggttgtga ttcggcagac gctgaaggcc atggtcaacc tttattatcc gaaggaccgg 442321 ctggagatta tcgtcgttaa tgataattca tcagaccgga cgggtgatat cgtcaatgaa 442381 ttttccgaga aatacgattt catcaaaatg gtgattacga agccgccaaa tgcaggaaaa 442441 ggaaaatcct ctgcacttaa ctcgggtttt gccgaatcga acggcgatgt gatctgtgtg 442501 tatgacgccg acaacacgcc tgagaaaatg gccgtgtatt acctcgtgct cggcctgatg 442561 aatgacgaaa aggcaggcgc cgtggtaggg aaattccgcg tcatcaatgc ggcaaagacg 442621 ctgctgacga ggtttattaa tatcgaaacg atctgttttc agtggatggc ccagggaggc 442681 agatggaagt ggttcaaaat cgccacgatc ccaggcacca acttcgcgat ccgcagaagc 442741 attatcgaaa agctcggagg ctgggatgac aaagcgctcg ctgaggatac tgagctgacc 442801 atccgggtat ataatctcgg ctatcacatc cgctttttcc ctgccgccat cacgtgggag 442861 caggaaccgg aaacatggaa ggtatggtgg cgccagcgca cccgatgggc gcgcggcaat 442921 caatatgtcg tgctcaaatt tttggcgcag ttttttaagc tgaaacgaaa acggattatc 442981 tttgatttgt tttatttttt ctttacgtac ttcctgtttt tctttggcgt gatcatgtca 443041 aatgcgattt ttgtagtgaa tttgttttat gatttgcatt tgtctgttgg atttttggca 443101 atgattctct ggattttggc gtttttctta tttatgacag aggtcatgat tacgttgagc 443161 attgaaaaaa cagaaatgaa caagcaaaac ttttttatcg tatttctcat gtacttcaca 443221 tactcgcagg catggattgt gcttgttatc tactctttat tcgtagaaat caagcaccgt 443281 ttattcaagc aagaggtcaa atggtacaag acagaacgat acaatcaaca taaaagcggg 443341 tgaccttttt gaaacaaata atgatttttc tcacaagctt catgctgctg gcgatgactg 443401 gacaaacggc tcttgccaaa gacgtacagg tcagcggttc gctccttggg aaaagcagcc 443461 aagaacaagc caaacagcag gtgctgacaa gcgagctgat tacactgtat ggatcaaaag 443521 acagcgcaga gctgacgtat cagatcccgg caggcgcctc ttcgggcaat cagcaattgg 443581 taatcgaata cgaggcatca aatcttttaa tttctccatc atcgttaacg gttgtcattg 443641 atgatgaacc ggtcaagacg ttaaagcttg atggtgattc caaacggaaa acagtgaagc 443701 tgaatctgaa taaaagccag tctgcgcaag gctatcacaa cgtatcgctg aaattctacg 443761 gcgtaatgaa agagggcgtg tgcgtcagac aggatacatc aggcaactgg atcaaaattt 443821 atccggacag ccggctgaca cttgctgaca gcagtgaagc gaagggaacg tcgctggacc 443881 attatccgta tcctttcgcc caatctggaa atacagcgga agaaacagct atcgtcattc 443941 cggataaccc aagttcagca gaaatagaag ctgctgttaa aacagaaggc tatttgaaaa 444001 cggtggacag cagtgtcagt attgcgtatg tcacggaatc tgaactgaaa aaaatcgata 444061 agccgacgat tgttatcggc gtggacaagc attggaacgg caaagtgaaa aaactgttga 444121 aacaagccgg gctacaggca aaaggagaaa accttctgct tgcggagcgg gtgctgaaag 444181 cagagggcaa acagcagccg gttctgtttg cgcaagcggc gtccgaggac gcgctcacaa 444241 aaaaaatcag cgtgatgaca gatcagacat atacaggcca gctcagcggc gatacacttt 444301 caatcagcaa gcttcagcag actgaaaaaa aagaaagcga taagctgacc cttgagaatt 444361 ttggagcggg tgatatcaca attggagccg acaaaacatc ttcagcacat tatttttatc 444421 cggcttcggc tgttttagat gaaaaccaat cggcgaagct gtcgcttaaa ctgaaaaagt 444481 ctgaaacgat tcaagcctca acggctgaaa acgagtcagc ctctcaggct gcagaactga 444541 aagtgatgat caacggccag ccgcactcgg tccggcttga tgaattagga aaagaagata 444601 aaaacggatt ctatcatgtc acagtgaaag tggaccctaa gctgctgcaa aaaaaccgct 444661 acattgatat tcagttcgtc acgaccggtt taaaggaaaa caacccttgt aacaccactg 444721 atgaagaaaa gtgggttttt atcgataaaa acagtacatt atcatacgcc atcaaaggca 444781 tgtccccgtc agcggatttt caagagtggc cgctgcctta cgccggaaac caggatcaaa 444841 caacgttaat cgtgcttcct gacaccgtaa gccaatcgaa gctagaggag ctttctctcg 444901 taacagaatc ctttggcaac gaagcacagc attcatatac ggtaaagaaa tcatctgacg 444961 ttacagcaaa tgatgcgaaa ggacgaaacc tcattttcat aggagggatc aatcaatttt 445021 ctcttctgaa ggagaaatca tcagatctgc ttgtgccgca ggaaaagaac ggctcgtttg 445081 atgtatctag tttcgagatg ctgaatgaga cgacaaaaca agtggtattt acccaagcat 445141 cggtttggga ttcacgctat acaatggctg tctttgcacc gtcaaaagga gatggcacgg 445201 ctgtcacaaa agagatcatc agttatctga acagcaacga tgagtcggca accgtcctta 445261 atgaaacaaa cagccagcag gtgtttacaa accaccagca gctcaaatcg gaaacaaaca 445321 gttccgatgc agaacaacca acacaggatc atagccagaa atggatgtat attggtgtgc 445381 tggcactcat tatggtggtt gcggcagtgt tcatttggat tgccgtaaga cgcaaaaaaa 445441 gaaagacaga tacagaataa aacagaggcg attttagcct ctgttttttt atttttggta 445501 agtaaattcc atttgtggaa cctgtcattt tatttttttc tctcagccaa taagcctctt 445561 tacaacgtgc gggaacggga gtatgatctc ttttagaaaa caaatcgctt aatctgaaat 445621 cagagcgggg gacccaatag aacggctttt tgccgttggg gtgaatcctt tttaggtagg 445681 gctaactctc atatgcccga atccgtcagc taacctcgta agcgttcgtg agaggagatg 445741 aatgaaacct gtgttcgatg ttatggcaca ggggcatccg tttgcctctg tgttttttgt 445801 tgttcatttt tgaatgcaaa tcgcatacag agacatcata gcagaaagga ctatcatcaa 445861 catgtgagag caagacactg atggatgttt tattgtttta attgaaaaat gagaaattaa 445921 aaggggaaga catcgatgta tcattcaatc aaacgttttt tgattgggaa accactaaaa 445981 tcccaagcag ctggagagca aaaactgacg aaattaaaag ccttggctat gctttcctca 446041 gatgcgctgt catctgtcgc atatgggaca gaacaaattc taatcatttt ggcaacaatc 446101 agtgcagccg cattttggta ctccattccg attgcggttg gcgttctcat cttgctgctc 446161 gcactgattc tttcatacag gcaaattatt tacgcttatc cgcagggcgg cggggcgtat 446221 atcgtttcta aagaaaatct cggtgaaaaa ccgggattga ttgcgggcgg ttcattgctt 446281 gttgattata ttttaacagt agcggtaagt atttccgcag gcacggatgc catcacgtca 446341 gcctttcctg cattgcatga ttatcatgtg ccgatcgcta tttttctcgt gttagtgatt 446401 atgattttga acctgcgcgg gctttcggaa tcagcatcca tacttgccta cccggtttat 446461 ctgtttgtgg tggcgctttt ggttctcatt gcagtcgggt tgtttaaact tatgacagga 446521 caaatagacc agccagccca tcatacatcg ctcggcacac ctgtagccgg cattacgcta 446581 tttttgctgc ttaaggcttt ttcctccgga tgctcagcgt tgaccggggt tgaggccatt 446641 tctaatgcga ttcctgcatt caaaaacccg cctgcgcgaa acgcggcaag aacgcttgcg 446701 atgatgggga ttttgctggc gattctgttt tccggcatca cggttctcgc gtacgggtat 446761 ggtacggcgc cgaaacctga tgaaacagtg gtttcacaaa ttgcgtccga aacctttggg 446821 cggaatgtgt tctactatgt catccaaggt gtcacatcgc ttattttggt tcttgcggca 446881 aatacgggat tctcagcctt cccgcagctt gccttcaacc tggcgagaga ccagtatatg 446941 ccgcgaatgt ttacagtcag gggcgaccgc ttaggcttct caaatgggat tatcttttta 447001 ggctttgcct ccattgttct cattatctta ttcgggggac agacggagca cttaatcccg 447061 ttatatgctg tgggcgtatt tattccattt acgctttcac aaaccggcat gtgcatgaaa 447121 tggatcaagc aaaaaccaaa aggctggatc ggaaaaatgc tgatcaactc ctgcggcgct 447181 ctgatatcat ttatggttct atccattctg tttgtgacga agtttaatgt cgtatggcct 447241 gtgttaatct ttatgcctat cgtcgttttg ctgttttttg cgattaaaaa tcactatact 447301 gcggttggtg aacagcttcg catcgtagac aaagagccgg aagaaatcaa aggcaccgtt 447361 gtgattgtgc ctgtggccgg tgtcaccacc gtcgtgcaaa aatcgattca ctatgcgaaa 447421 tcactgtccg atcaggtgat cgccgttcac gtgtcatttg acagagaaca ggaaaagaaa 447481 ttcgaaaaac gttgggaaga gcttaataac ggagtgcgtc tcgtgacgct tcactcctct 447541 tacagaagcc ttgtccatcc gtttgataag tttttggaaa cagttgaggc aaaagcgaag 447601 aaggagcagt tttccgttat ggtgctgttt ccgcaattta taacgaaaaa acgctggcac 447661 accatccttc acaaccaatc ggccttcctc ctcagagtcc ggctgttctg gaaaaaggac 447721 ataatggttg ccacactgcc gtatcatttt aaaaagtaaa gctctaggac caagggaatc 447781 accttggtcc tttttagcgg gaaaaggagg tatgggggtg tatacacaag gtgcttttgt 447841 gatcgtattg aacgaaagtc agcaaattct gctggtgaaa cgaaaagatg tccctctatg 447901 ggatttgccg ggcggcaggg ttgatcccgg ggaatcggct gaggaagcgg cagtgcggga 447961 gatattggaa gaaacgggat acaatgcagc gctttctgcg aaaataggtg tttaccaaag 448021 gccaaagttt caagatgaac agcatctgtt tttcggaagc attacaggcg gacaagcaat 448081 ggctgacggc acagagacag cgggattaaa gtgggtttcc ccggggcgtt tgccgctttt 448141 tatggtgccg aatcgaaaaa ggcagatcaa tgatttcaag aacggcgctc aagatgtaaa 448201 tgtcaccgtc aaggatagcg ggttgctcgc ggcgatcgac ctgttgaaaa gaagactggg 448261 caagtgattc aggtctccgg gttttaaagc ctttctcctg tggtattgaa aaaaggaaaa 448321 aggaggatac gttatggcac acaaaactgc aggacaagca atgacagagc tgcttgagca 448381 atggggagtt gatcatgtat acggcatccc cggagacagt ataaatgagt ttatcgaaga 448441 attaagacac gaaagaaatc aactgaagtt cattcaaacc cgccacgaag aggtagcggc 448501 actggcagcc gcggctgaag caaaactcac cggcaagatc ggagtctgtc tgtcaatcgc 448561 agggccggga gcggtgcact tattaaatgg tttatatgat gctaaagccg acggcgcccc 448621 tgtgctggcg attgcaggac aggtttcttc tggcgaagtc ggacgggact atttccagga 448681 gattaagctg gagcaaatgt ttgaggacgt ggccgtgttc aacagagagg tacatagcgc 448741 ggaatcactt ccggatctct taaatcaggc gatcaggacc gcctacagca aaaaaggcgt 448801 tgcggtattg agcgtgtcag atgatttgtt tgcggagaaa atcaaacggg agcccgtgta 448861 tacttcaccg gtgtatattg aagggaacct agaaccgaaa aaagaacagc tcgtcacctg 448921 cgcccaatat attaataacg ctaagaaacc gattatcctg gcagggcagg gaatgaaaaa 448981 ggcgaaacgg gagctcttag aatttgcgga caaagccgcc gctccgatcg ttgttacact 449041 cccggcaaag ggtgttgttc ccgataagca cccacatttt ctcggcaacc tcggtcagat 449101 cggaacaaag ccggcttacg aggcaatgga ggaatgtgat ttattaatca tgctcggaac 449161 gtcattcccg taccgtgatt atttgcctga tgacacgccg gcgatacagc tcgattcaga 449221 cccggcaaaa atcggaaaac ggtatccggt gacagcgggc cttgtctgtg attcggctct 449281 cggtttgcgc gaattgacag agtatattga acgcaaggaa gacagaagat tcctgaatgc 449341 ctgcacagaa catatgcagc attggtggaa cgaaattgaa aaagatgaga cagaggcaac 449401 aacaccgctt aaacctcagc aggtcgtggc ccgtcttcag gaagcggcag ccgatgatgc 449461 ggtgctctct gtagatgtcg gcactgtgac agtctggatg gcgcgtcatt tcaaaatgaa 449521 cgcgaatcag gatttcatcg tttccagctg gcttgcgaca atgggctgcg gcctgccggg 449581 agcgattgca gcgagcttgt ccgaaccgga acgccaggcg atcgccgtct gcggtgacgg 449641 gggattttcc atggtcatgc aggaccttcc gaccgccgtt aaatataagc tcccgatcac 449701 agtcgttatt ttaaacaacg aaaatctcgg catgattgag tacgagcagc aggtcaaagg 449761 caatatcgac tatgtcacaa aacttcaaaa tgtcgactat gccgcatttg cagaaagctg 449821 cggagcaaag ggcatcaaag tgaccaaagc ggaagagctt gcgccggctt ttcatgaggc 449881 gctgcactct gaccaaccgg tcgtagtgga tgtcatgatt ggaaacgaac cgccgcttcc 449941 tggcaaaatc acctacgggc aggcgaaagg ctttagcaag tacatgctga aaaacttctt 450001 cgaaaaccaa aaatttgaaa tgccgtcact gaagaaaagt ttgaaacggt tattttaaaa 450061 aaacaggggc cctaagagcc cttgtttttt tttttttttt tggaaacaaa tgtattttca 450121 gcatgtttga attcataaaa tgatcggtat atgtattagg aactgatttc gccatactcg 450181 aaacagacaa aaggacaaat gcatcttgtt tcaaaggaag atgcatttgt ccttgcatgc 450241 ttattcttat caaatcttac agaactcttc tcataatagg ttatttttct tttttcttca 450301 gcccgaagaa gaaaggaaaa gcagaaccga ccaagaaggt gccgaataaa aacatgccgc 450361 cgataaacac gtggaaattt gtgtgtccgg ccgtaaacgc cgtgattagg gaaatgatac 450421 tgagcacgat catggcaatg ccgggcgcga ctctcatttt tcccttggat ttatgggcag 450481 caacagaaca taaaatgccg ataacaatag gaacaatcca caaataaaac agaataaata 450541 ctgacatcat caaaactccg atttttcttc tatcataaca aatttctgtc aaaaagggta 450601 tcaatgagct tttgcggaaa aataaaaacc ggctttagaa gccggttttt ttatcgaaac 450661 gtatctacaa ttaaaaacac attcaaagca acgatcaata cagcaatcag ccaagacacc 450721 actgtgatcc atttggcgtt gatcagagat cccatgatcc gtttattgct tgtaaacata 450781 ataagcggaa tgagggcaaa ggcgatcccg aaggacagca cgacctggct cagtacgaga 450841 gcggtcgtcg gattaacacc tgacgcgatg atcaagatcg gcggaatgat cgtgataaaa 450901 cgccgtacat acagcggaat gcggtagttg ataaatcctt gcataatcac gtcgcctgaa 450961 agtgtgccga cagacgaact ggatagaccg gcaacgagca gcccgatccc gaacaaagcc 451021 gcagacatag ggctgacaag atgtccgaat tgctgaaatg cgacgtcgag atcctcaaca 451081 aacaggccgt ttttgaagaa taatgcggca gccacaatca gcatacttgc attaatagcc 451141 cctgcaatca gcatcgctat taaaatatca ataaattcaa acctaaagat ttttttccgt 451201 tctgcatcag ttttgccaac cacccgccgc tgtgtaaggg cagagtgtaa ataaatggcg 451261 tgcggcataa cagttgcgcc aagaataccc gctgcaagaa gcacactgtc ggtgccatga 451321 aacgccggga caaaaaggcc cttcatcact gacacggcat caggctttgc gaaaaaggtc 451381 tgcaacgcaa aggcgatcac gaccacaaac agcataccgg caatacctgc ttcaagtgag 451441 cgataaccac ggcgctgaag ctccaatatc gcgaaagaac cgatcgccgc aataatagac 451501 gcttcaagca tcggaatgcc gaacagcaaa tacagtccca gagccgctcc gataaattcc 451561 gccagatcag ttgcgataat gaccaactcg ccctgaatcc ataatccgat cgagacaggc 451621 ttcgggaatt cttcacgggc aacctcaggc agatttttgc ctgtcgcaat accgagtttg 451681 gcggataggg attgaattaa aagcgccatg atattggaaa ataagatcac ccataagagc 451741 atatatccgt atttagaacc cgccgaaata ttcgttgcga agttgccggg atcaatatag 451801 gcaatggctg ctataaatgc agggccgaga aaagggagca gccctctgaa tcctctgatt 451861 ttcccgtcaa gcgcatcttg gacggctttg gaacggggag attgtgctgt gatgtccttg 451921 ttcatcatgt ctcacctgaa ttctgtttgt ttttgccgta caacaaagag tttccttaag 451981 gcaaattatt ttatctacat catatgacca tcccggtttc ttgtcaaccg aaaatgttca 452041 aaatacactt ctgaattttt ccctgttatg taacatgata tgtagggatt cgtgataagg 452101 tcccatataa aaagacatcg tttcatttcg aaacgatgcc tcctgtatct aatgagtcta 452161 ggcttccttc cgcagcccgc ggaatataag gcccagcaag aacacgaaga tggctgcccc 452221 gatgatggcc gggaaaatag caaagccggc gaggctcggt ccccatgtgc caagaagtcc 452281 gtgcccaatc caagcgccga tcagcccggc aatcatagag ccgaaaattc ctcccggcag 452341 ccggtttcct acaatggcgc tcccaattaa tccgataaca attgcaacaa ctaatgaaac 452401 caaaaagcta agcatcatga tcacctctca taaatgattt accaatcaat aaccgctcct 452461 gatcatttcg aaacacttga aagcatattc ctttatgatc ctgttttaat ctttctctgc 452521 acactgccgt cagctaaatg aacaatgacc tcagtgcctt tatgcgccgc gatttccttt 452581 gcccgttcaa tcgcttcttt ctttgtatcc ttgatttcag acacacgttt ggcgccctcg 452641 gctttgactg cccagccttt tttatgctta ataacatgct ctgctttatt catgagctcg 452701 gggccgctgc cgctgcttgg atcagcatcg cgttctgtct catcatcatg cgtcaggaaa 452761 tcatcaattt catctgtaga ggcgttttcc gcccattcct tcgctttgct tgtcgcaatt 452821 ggaatcgcgc gcccttcctc atagccttca tcaatcatcg cattcgcaat gtctatcgcc 452881 ttttttctca ccggcttctc aagatttttt aatgaagcag gataatcctt catcgaccaa 452941 ggcatgtcta tcactccttt tccttttata aaaatggtac ccgcaggtga aaaataaaaa 453001 cgcatccgaa aaaatgaagg tatactatat agtagaaaaa acggaaggga agtgcgggtt 453061 gggtgccaac agaacgaaaa gaagacttac atcagcaatt aaaagagata gagaaatggg 453121 aaaaagatca gcaaaaagtc tggttttggg aaaagctcag ccgtctcccg tttcaactcc 453181 tggacaagct gacaccagaa ttcatccaga aaaagatcgg caagctcttg gatgaggtcg 453241 gcagctttgt tcaaacaggc ggacagtacc tgacatctga aaaacagatt atcaggatgt 453301 ttcaaaagaa actgccggag gagatctttg aatcgctgga ggacatccgg aaagcgcctc 453361 ttcctgtcat ggatgaaatt gcggaaggaa tgggcaaaaa cagaaccaac gcagcaaccg 453421 ttcaaggcgc gacaaccggt gtgggcggcg tgtttacgct ggcggcagac attccggcag 453481 tgcttggctt atcactaaaa acattacagg atatcgcagt cgcatacggc tatgacccaa 453541 aggagaaaaa agaacgagtc ttcattgtga aatgcctgca gcttacgtcg gctgatgttg 453601 tcggcaaaag atcgattttg caggaattaa aacactacga tcaagaccgt acatataaga 453661 atgtcgcttc tcaaatccaa ggctggcgag aagtcgtttt gggctatcga gacacgtttg 453721 gctggaaaaa acttttccag atagtgccgg ttgccggaat ggtttttggc gccgctgcca 453781 atcgctcaac attaaacgac attaccgaga caggcatgat gctgtacaaa aagaggcgca 453841 ttcttgaacg actgaaagaa acagaacgag agatggaata gcagaaagca gacggacacc 453901 gcgatccgcc tgcttttttt agtggaaaca tacccaatgt gttttgtttg tttaaaagaa 453961 ttgtgagcgg gaatacaaca accaacacca attaaaggag gaattcaaaa tggcagacaa 454021 taacaaaatg agcagagaag aagcaggtag aaaaggcgga gaaacaacaa gcaagaacca 454081 tgacaaagaa ttctatcaag agattggtca aaaaggcgga gaagccacta gcaaaaacca 454141 tgacaaagaa ttctatcagg aaatcggcga aaaaggcgga gaagccacta gcaagaacca 454201 tgacaaagag ttctatcaag aaatcggtga aaaaggcgga gaagccacta gcgaaaatca 454261 tgacaaagaa ttctatcaag aaatcggccg aaaaggcgga gaggcaacaa gcaaaaatca 454321 tgataaagaa ttctaccaag aaattggctc aaaaggcgga aacgcccgca acaacgacta 454381 atcaaaagca taaaggcaga caacctgtaa ataaaaaagc gatccggcac atcagctgga 454441 tcgctttttt ttggaatctt ctcaatttat gccgctattg agatacaata agtgaaaaag 454501 gggttttcgc taatgtccaa gatgcaaaac ttgctcgcca tcgcaaatga agtcaaagaa 454561 aagcacgcca atttttcaat ctcagaggtc aacgaccact gcgtgcgcct tgcggtgttt 454621 acgggagaat atgactggca ccatcaccct gactcagacg aattgtttat tgttcttgaa 454681 ggggagctgc tgatcgattt taaggacaaa gaaaccgcgg tgctcaaagc aaatgacagc 454741 ctgctgatcc ctaaaggcac ggttcaccgc acacgctctt acgtcagaac ggtaaatctc 454801 tgtgtggagc ataaacaagc cgaaaccgtc atcatagagg agcagccatg ctaatcaaaa 454861 agatgatatg tgaagtagat gctgcaaacg ctgaagcatt tgcaaaagcg cagtcacagt 454921 gggaagcgtt atcgcatata agcggcttta tcaaacaggc cggcggctgg cgaaaaacga 454981 tagacgagcc gctcaccgca gaaatcatca gtgtatggga aaacagagaa gcctatgatc 455041 attttatgga gaacgaacat gacagcatat acgaggaaaa cgatcagaag gctgtaattc 455101 tttcgataga ggtgacggtg tacgaagagg ataaaccgtt cgttcacgat ctgttacata 455161 accccgatat ccggtacgaa ccaaactgga cggttctgaa ggcataatca aagcccaaaa 455221 catcatgttt tgggcttgtc tctttactcg cgtcccggaa gtgtattatg aacaaaaggc 455281 ggtgctggtt ttaactccgg tttttctcca aacgtttttg cttctttcac atattcaaag 455341 gcttctccgt ccggcgcttt ttcattcagc cagttttgct cggcgcttac ttcgccttca 455401 gagaaattga taagctgatg tgagaactct tgtttttcga gcgctttcgg gaatgtaccc 455461 ggcacaaccg gaccttcctg tgcttctaat tctttaatgg cggcgagcca ttggttctgg 455521 tgcatcgtgt cacgcgccag caggaagctg agcatatctt tgacgccttt gtcatccgtc 455581 atttcaaaca ggcgtgcgac ctgcagacgg ccctgagatt ccgcattcag gttggcgcgg 455641 aagtctgcca gcaggtttcc gcttgctacg atataaccgc cgctccaagg tacgcctgta 455701 ctgctttccg gcatggcgcc aagtcctgat acaatcgcat ggtgagggtt catgccgcct 455761 aggatggagc cgatgaccgg atcttcagca gctttttcct gctgatcaag aggggcatcc 455821 tcaagaagtc tggcaatcat cgttgcgatc atttcaacat gcccgagctc ctcagttgcc 455881 gtatccatca gcaagtcctt gtatttttca tttcctcttg tgttccagcc ttgaaataag 455941 tactgcatgg caactgaaat ttctccgaat tgcccgccta aaatttcttg cattttttta 456001 gcgaataatg gatctggacg atctggttta gcaggatgct gcagcatttt tgtgtgctta 456061 aacatgtacc catctccttt ttcgtttatc tctttttata tttccgatcg atagaaagat 456121 aaacgaaaaa cagcgtatcg agatgggaac tatgaatctt ttcgcagctc caacagttcc 456181 cggatcagct cccggccaaa gatgggctca tactgccggt aaacagggtc aagacgcttc 456241 atccattctt gtttctcttt atctgacagc tcataaatat gtatagcaga attctttttg 456301 atttcttcca gctgctcctt gttcatttgt tcggcatacg tttcattcca ctccgttgtc 456361 tccttcatcg cttcagtcaa aatgcgtctt gtttctggtg tttgcgcctt ccagaagtgt 456421 tcatcagtca tgacagcgta gccgagataa ccgtggctgc ttattgtcaa atagtcctga 456481 acattataaa attttttaga atagatgttt gaaattgtat tttcttcgcc atcgactaca 456541 ttgttttcta acagctgaaa ggtagaattg aaggattcct gatgaggtgt tgcgccaagc 456601 agcttgaact gatcctcaat cacatcgctt tgcataatgc gcagatcctg cccttttaag 456661 tcatccggtg ttttgaccgg cccttgattt gttgtgattt gcttaaagcc gttcgtccaa 456721 taggccaatc ctttcaattg gtttttcttt agagaatcaa acagctgtgt gccgatgctt 456781 ccgttcagcc cttttttgac ggcgttgtaa tctgtaaatg catacggcag atccagcact 456841 ccccattcag gcgagagcat gccgagcttc gatgtggagg gggcgataaa ttgaacatcg 456901 ccgttttgca atgcttcaat ttcttcaatg tccgagtaca ggcttccatt cggaaatact 456961 tctattttta tttttccgcc tgatttttcg ttcaccagat cagcgaattt attggcggcc 457021 agcccttttg gcgtattttc agcaaccacg tggctgaatt taaacacgat ttgatcctgc 457081 aggccttcct ggtcgtcatc ataaacaatc tttttattgc cggtatgatc atggaatccg 457141 ataaataaag cggttgcaat tccagcgatc atcagtgcga gacatgcaag caaactcttc 457201 atgaaaagcc ctcccctatg ttaaggataa tgggggctat gacattcgta aagacctgaa 457261 aggagaagct gatgaacaaa aagaagctct caatccgttg gaaaatcacg atcttatcct 457321 atatactcgt cattttctcc tttttgatcg gcggcattgt gctcatcggc aacattcagc 457381 atacagagga gcgggagctg aaaaagcggc tgatgaatac ggcccggacg gtgtcagaga 457441 tgacagaagt gaaagaagcc ttggcgcgaa aaaaacaaac agaagcggtt cgccatgcgg 457501 ttgaagaaat caggatgatt aatgaagcag actatattgt cgtcatggat atgaatcaca 457561 tccgatatac gcatcctgtc agcacaagca ttggcaagaa atcagaaggt gcagacgagg 457621 aggcagcttt tgcggagcac atttatttct ctgaagcaaa gggcgagatc ggcacggcgg 457681 ttcgcgcttt ttatccggta aaggatcaag acctgaacca aataggcgtg gtgcttgtcg 457741 gaaaaacgct gccggggatc gctgacatcc tgcttcattt aaagcgtgat atcgccttca 457801 tcgttgtgct gacactcggc tttggccttg ctggttcctt tttgctggcc cgccatatca 457861 aaaaacaaat gtttcagctt gaaccccatg agattgtccg aatgtatgaa gaacggacag 457921 cgacgtttca ctcgatgaat gaaggggtga tcgctattga caatcgtctc gtcattacga 457981 tcttcaatga aaaagcgaaa cagatctttg aagtgcaggg ggatctaatc ggcaaggtga 458041 tttgggaggt tctcaaggat tcgcgcctgc ccgaaatcgt ggagcggaac aaagcggttt 458101 ataatgaaga aattcgtgtc agcggtaagg tgatcatgag cagcagaatt ccgatcgtca 458161 tgaagaaaaa agtgatcggc gccgttgcga tttttcagga cagaacggaa gcggccaaga 458221 tggcagagga attgactggt gtcagaaact ttgtggaggc gctccgtgtc caaaaccatg 458281 agcatatgaa taagctgcac acgatcgccg gtctcatcca gctggggaaa tctgaaaaag 458341 ccttgcagct tgcattccag gcgtcaactg agcaggaaaa tgtgactgaa tttctgcacc 458401 gctcgattca aaatgacgct gcggcaggcc ttctattaag taaaatcaga aggggaagag 458461 agctcggcat tgctgttcat atagatgaaa acagcagtct tcagcaattt cccgagcatg 458521 ttgatcagca tgatattgtc gtgcttttgg ggaatctgat tgaaaatgcc ttcggctcat 458581 ttgaaaccgt tcaatctgaa gacaaacgaa ttgacattag tatcgaacaa acagatgata 458641 tccttgctat tttaatagaa gataacggct gcggaattga accgacacat atgcctcgcc 458701 tttatgacaa aggttttacg gtcaataaaa ctggcggcac aggctatggc ctgtatctag 458761 tgaaacaaat catagacaaa ggatcgggca cgatagaagt tgattcacat gcggggcagg 458821 ggacatcttt ttctatcgtt tttccaatga agggggagga agcacagcat ggctcgtaaa 458881 gaatggaagg ttctgctcat tgaagacgat ccgatggttc aagaggtcaa taaggatttc 458941 attacaactg ttaaaggcgt tactgtctgt gcaacggcag gaaacggaga ggaaggcatg 459001 aagctgatta aagaagaaca gccagatctc gtcattctcg atgtgtacat gccgaaaaaa 459061 gacggcatca agaccttgca ggagatcaga aagcaaaagc ttgaagtgga tgtcattgtc 459121 gtctccgctg caaaagacaa ggaaacgatc tcactcatgc tgcaaaacgg ggcggttgac 459181 tatatcttaa agccgtttaa gcttgagcga atgagacagg cactcgaaaa gtacaagcaa 459241 tataaacaaa aaatcgaagc gaatgatacg ctgtcccagg aacagctcga tgcgatcctg 459301 aatattccgc agcaggccgt acaggatctg ccgaaagggt tgaatcactt cacgatgaat 459361 gaagtcactg cttttttgaa acagcaaacc gcatcccttt ctgctgaaga ggttgccaag 459421 gcgctcggca tcgccagagt gacagccaga cgatatcttg attacttaga aaaaaccggg 459481 atcatcaaat tggacgttca atacggcgga gtcggccggc cggtcaaccg ctacgtgtta 459541 aaaggataaa cctgagacca aaaagaccaa aatgtccgtt atgatcataa acttccccag 459601 actgtatgaa aacgctatca ttctagtaag aaagacacaa aaggcgaata ggacaggggg 459661 atgaaggata tgaaactgtt taaaaattta acagttcagg tcataaccgc ggtcatcatc 459721 ggggtcattg tcgggctggt ctggccggat gtcggcaaag aaatgaaacc gcttggtgat 459781 acatttatca acgctgttaa aatggtgatc gcaccaatca ttttcttcac aatcgttctc 459841 gggattgcaa aaatgggcga tatgaagaag gttggaaaag tagggggaaa agcgtttatc 459901 tatttcgagg ttgtcaccac cctcgcactc attatcggtt tatttgtcgt caatattatg 459961 aagccgggtg cgggtcttga ttacagcaag cttgaaaaag gagatgtatc acaatacacg 460021 caaaatggcg gtcagggaat cgactggatt gaatttatta cacacattgt tccgtccaac 460081 atggttgatg ccttcgcaaa aggggacatt ttgcaggtct tattcttttc tattcttttc 460141 ggagtgggtc ttgcggcatt aggcgaaaaa ggaaaaagcg tcattgattt cttcgacaag 460201 gtttctcacg tttttttcaa aattatcggc tacattatgc gtgccgcgcc aatcggggca 460261 ttcggggcga tggcgtatac aatcggacac ttcgggctcg attccatcaa accgctggca 460321 agcttaatga tgtctgttta tattacgatg ttcctgttcg tatttgttgc tttaaatatc 460381 atctgcaagc tttacggatt cagcctgtgg aattaccttc gcttcattaa ggatgagctt 460441 ttgatcgtgc ttggcacaag ctcttccgaa tcggtgcttc cgcgtatgat ggataaaatg 460501 gagcgctacg gctgttccaa atccgttgtc gggcttgtta ttccgacggg ctattcgttt 460561 aacctcgacg gcacatccat ctatttatca atggcgactg tctttttggc acaggtgttt 460621 ggagtagacc tcagcatcgg ccagcaaatt acgattatcc tcgttctgat gctgacatcg 460681 aagggagcgg caggtgtgac gggaagcgga tttatcgtcc ttgcctcaac gctgtcagcg 460741 ctgcaggtca ttccgctgga ggggcttgca ctcctgctcg gggtcgaccg tttcatgagt 460801 gaaggaagag ccattgtgaa cctgatcgga aacggaatcg ccacgatcat tgttgccaaa 460861 agcgaaaatg aatttgatga agcaaaaagc atagaggctg ttgaaggcat gaaaaaaatg 460921 aaaacagcag tctgaaaaaa gaacggccca tccatgggcc gtttttttaa ttgtttaaga 460981 attattaagg taaggacaga gacctcagca tttttttgtt atataattta caaatggata 461041 ctatattgaa tgaaggacgt ttgtcctaac aggagtgtat aaatggccgc tttagttaaa 461101 ttttttcagc acccgggagt aaggcgtttc tccatctttg tcgtgttaac tggtgtgtta 461161 tatctattta agagcatgat caacttaata ttgcttacct tcattttcac atttctaatg 461221 gatcgtttgg agcttgtcgt gcggcagttt gtaagccagt tcttccgcgt gagccagcgg 461281 gttgtcatta cgtttcttta catgttgctg gctgtgctgc ttacagtcgg gggctttgtg 461341 ttttatccgg tcgtcgcggc gcagatccag cagctggtaa agcagattaa acatattgcg 461401 tatcatcctg acagcatccc tttctttgat gagatcacca gtgtcttcgg agatattaac 461461 atcagttcat atgtcaaaga gggcttcaat gtagtgtata cgtatctggc cgatatcagc 461521 acattcggct tgcaggtcgt gatggcgctc attcttagca tgtttttctt atttgagaaa 461581 aaacggcttt ctgaattcat ggcgaaattt aaaacgagca aacttagggt cttttatgag 461641 gagattgctt ttttcggaag caaatttgca agaacgttcg gcaaggtgct cgaggctcaa 461701 tttatcattg cgctcgtcaa ctgtattctg acgtttatcg cgctttggat tatgcatttt 461761 ccgcagctgt ttgggctttc gattatggtg ttcttccttg gattgatccc tgtagcaggc 461821 gtcgtcattt ccctgattcc gctcagcatt atcgcctaca gcactggcgg tggaatgtat 461881 gtgctctaca ttgtccttgt catattcgcc attcatgcga tcgaaaccta tttcttaaat 461941 ccgaagctga tgtcggcgaa aacagagctg ccaatctttt tcaccttcac agtactcatt 462001 ttctctgaac acttcttcgg catttggggt ttaattatcg ggattccgat ctttgtgttt 462061 ctccttgata ttctggatgt caccaacaag gaagataggt ctaaaggacc ccgagagaat 462121 agcgataaaa agtagtttaa aatcgaataa tgagtgtgcc tcgatctgcc ggcctgcctg 462181 ttcagggcat ggaattaaga ctcggaatcg gagcttggca ttgccttgca cagtggtgaa 462241 cacaacaggt gacaatgctt gtcatcagta cggaaactga aaagaacaaa cagtcggagc 462301 aaacgctcat catcggttta accaaacatt tggaagcaac aaatgctata atacaaacag 462361 tgcctaatgt tgggcactgt ttattttttg tcgaaaaagg aggaaggctt tatggctgag 462421 ccgattttac atattgaagg cctcgataaa aaaattgggt ctaaacagat tttaaaacag 462481 atcagcatgg acgtcatgga gggtgaaatc atcggccttc tcggtccgaa tggttccgga 462541 aaaacaacac tcatccgtat catcgtcggg ctgttgaaac aaaacagcgg aagcgtgaca 462601 atcagcggat tccagcatga tacagagttt gaaaaagcga tggaagcggt tggagcgatt 462661 gttgagaacc ctgagttcta tccgtacctg acaggctggg aaaacctcaa gcactttgcg 462721 aatatgcaca aaaaaatagc ggatgaacgg cttgatgaag tggtggaacg tgtcgggctg 462781 acgtcagcga ttcatgataa ggtgaaaacc tattcccttg ggatgcgcca gcgtctggga 462841 atcgcccagg caattcttca ccggccgaag cttctcattc tagatgaacc gacaaacggc 462901 ctcgatcctg cggggatgaa ggattttcgg gatcatatta aggaactcgc agaaatggaa 462961 ggaacagctg tcctgttcgc cactcattta ttgcgcgagg ttgaagactt gtgcgaccgt 463021 gtcatcatca ttcaaaaagg tgagatcaaa gcggaagtca gcttacaagg aaccgatcaa 463081 accacagaaa aagcgattat agaagtgcag ccgcaagaaa aagcgctcaa ttggctgaca 463141 ggcaatcaat atcaagctga gagccaagac gggacgattg tagttgaggt ggcaaaagaa 463201 aacataccgg agctgaaccg atcacttgtc ggacaagatc tgaatgtatt ttccattacg 463261 ccttacacgc agtcactgga agacgaattt ataaaagcga caacagctca tcaagaggag 463321 ggagaagagc ttgtctaaat taatttggaa tgaacatatg aaacttttta atcggaaggt 463381 cactttggtt tctcttatcc tgatggctgt ctttcaattc ttcatggcat tgatcattaa 463441 acggattgtc atcagtgccg gaacagatga aaacttcatc ggctatttat cgtatacacc 463501 gagcctgaac attttgctgc aggctttaac gatcgtaatt gcagcaacaa ttgtttcgat 463561 ggaatttgat aaaaagacga tcaaattttt gctcattcgt ccggttaaac gccaaaaggt 463621 cttttggtca aaattaatca cagtcgtgat ggtcagcttc tatttgtatt tggcatacta 463681 cattctggca ttattattcg gtctcttgtt ttttggcaca tcggtgactg cggaatcaaa 463741 gacattgctg gtcaacacct tggcgctgat cgggtcaaac tggcttgaag ctgtaatgat 463801 gggattattc gggctgcttt gttcttcgct gttccgcaat agcgcggtag cagttgttgt 463861 ttcttttgtc gttttatacg gagcgagtac acttgttcag ctcatgaagt tgtttgaaaa 463921 caagtggggc agctttttgc tttttgcgaa cactgacttt acgcaataca gaagcggaga 463981 gacagcgttg ttttcaggca tgacgccatt gttttcaatt ggaattctca tcatacatgc 464041 catattcttc atcgttgttg gctggtggtg cttctgtaaa cgggatgttc gggtctaaag 464101 gcaaggaatg acatttttgt gaaaaagctc acgtaaatca atatcatttg atattttggt 464161 ttatactaaa ggtactgacg gaggtgtctc gattgaggaa ctttattacc gctttaccga 464221 tcgtattgct gcttggattc tcatttgtgt cattcatgtt tcagtttgaa catcttgttt 464281 atttcaggct cgcgcttggg ttgttttctc tcgtgggact gtacatgata tataaaatga 464341 agacgggcat ccgctatttt atcatctatc tgtatgccag ctggattgtg ttggccgcag 464401 tgaccgcttt tgaagagccg attttctcaa gctttttctt tggcggcctg gtgatgacga 464461 tgggttacct gacatatatg ctgatttatc tcggcatgaa acaagaccgg gatgcaaatc 464521 ctgtgtaatc gcgctgttcc cttggggaac ggcgtgtttt tctatactgg gcaaaaggtt 464581 aacagttgcg gaaaaatggc aggaaatcta taatacatat taaatttatc ggaattaaaa 464641 ctggggggct gccggatgtc attatttata caaaacgatc aacagcggca atggatggag 464701 aaaatcggac ggattgcgga tgaatttcag caaacagctg ctgaagatga cgaacaggga 464761 cgttttcctg cagagaaaat acaaaaactg cgtgatgctg ggtatacagc attaacattg 464821 ccggcatctc atggcggagg gggcatttct gtttacgata tgctcttgtt tcaagaacgg 464881 cttgcacggg gagatgctcc gacggctctt agcatcggct ggcatttgag cgtgatcggg 464941 gagcttggag aaggcaacag ctgggatgaa gacgtatttg catttgttgc caaggaagtc 465001 caaaacggag ccgtcattaa cagggcggcg actgaagcga aaaccggaag cccgacaaga 465061 ggagggcgtc ccggtacaca cgccgtcaaa aaggatggca aatgggcagt gaacgggaga 465121 aaaaccttta cgacgatgtc acaagctctg gattattttt tagtaaccgc atggattgag 465181 gacaaacaaa caacaggcgt gtttctcatt cataaagatg atcccggctt gtcgattgaa 465241 gaaacgtggg atatgatggc gatgcgggcg actgggagcc atgaccttgt actgaacgaa 465301 gtaatgcttg atgagaataa gctggtggaa ctgcttcaag ggcctcgtgg agctaagccg 465361 aatggctggc tgcttcacat tcctgcgatt tatcttggtg tggctcaagc tgctcgtgac 465421 tatgcagtgc aatttgcatc tgagtattct ccaaacagct tgaatggacc gatcaagaat 465481 gtcccggccg tacagcaaag aacaggcgaa atggagcttg aactgctcaa tgccagacac 465541 tttcttttcc atatcgctca attgtatgac gatccggtgc ggcgtccaca cttgaccagc 465601 gagctcggtg cggcgaaaca tatcgtcaca aacgctgcgc tgtctgttgt tgataaagcg 465661 atgagaattg tcggggccaa aagcctggaa cgaaccaacc cgcttcagcg ctattaccgt 465721 gatgtgcgcg ccggtcttca caacccgccg atggatgacg ccgtgataca caagctggca 465781 gctgaagcgt ttgagtcata aaaaaaagag ccttaccggc tctttttatg tattgttttg 465841 ctcttgcaga tttttttgat gcttgcggtc gatcctgtca taaataacgt tcatcagctt 465901 tggattgccc ataatcgcct ctttgttttc ctggatcagc tgttggtaag ttttcacttt 465961 acgcttcggc atgctccggc gccctcctga catgtttgta ttcactttct aactccgtca 466021 gcgacaattc atacagatga cgctttgact ttttgtatat accattctgt attaacagat 466081 gaatgagctg tttttttctg atttctgcag actgaggtgt cattgtgtca ccaacctcca 466141 atcaaacgat attgataatc attatcaatt aacttcagta tacaatgtcc gcaatagcct 466201 gtaaagatga aaagagtcct attcttggcc aatttacaaa cattcaacaa atcgacaaaa 466261 agtttcccgg gcaataattt gctgtcgaaa tattccgctt cattgaacgc accctgctat 466321 ttttcatgtt ttgaaccata ctatgtaata gaatggaggc tggtattcaa tggagcggac 466381 agaaaatctg aaaaagggag aaaaaggggc gctcctcaat atttttgcat atgtcatcct 466441 tgctgttgta aagctagtta tcgggattct atatcattct gaagcgctga gagcagacgg 466501 gttaaataat ggaacagata ttgttgcgtc agtagcagtg ctgataggat tgcggatttc 466561 tcaaagaccg gctgacagcg atcatccata cggccattat cgggctgaaa caatttcgtc 466621 tcttgttgcg tcttttatta tgatggcagt cggcattgaa gtgttaatcg gcggaggaaa 466681 agcgattgcg ggcggcacaa cggaaacgcc aaatcttatc gcggcatgga cggcgttagg 466741 cagtgctgtg tttatgtatg gcatctattt atataacaaa aggctggcag cgtccattaa 466801 aagctctgcc ctgatggcag cggcaaagga cagcaggtca gacgcttttg taagtgccgg 466861 cgcgtttatc ggtgtttttt cgtcccagct gaagctgccg tgggttgatc cggtaacggc 466921 ttttatcatc ggcatcatca tttgcaaaac tgcgtgggat atctttaaag acgcttcaca 466981 ttccttaaca gacggcttcc atttaaaaga tcttgagcct tacaaacaga ccgtcggcag 467041 gatcgaaaat gtgcatcgcc taaaggatgt gaaagcgagg tatttaggca gtacagttca 467101 tatcgagatg gtgattacgg ttgatccgaa gcttacagta gaagaaggcc atggagtggc 467161 ggatgaagta gaagacaaaa taaaacatga acacgatgtc actcatgttc atgttcatgt 467221 agagcctgac gacataaaat aaggctgttt aacgaattag cttatatgtt cagataaaaa 467281 ttcagtcact tcttcaggcg ttttggcatt ggcgctgtga aggtgagctg ttttttcacc 467341 gttcttgaaa ataagcaggc tgggaatgcc cattacttgg tatttttcag ccaggtcagg 467401 aagctcgtcc ttattcagct cataccagtc gttttggttg tattcttcca aaatatcgcc 467461 gatgaacata ttcatgcgtg tgcagtctgg gcaccaatca gcataaaact ttacaatgat 467521 ttctttatca gattgaatca gttcattaaa ttgttcgttt gttgtgattt ttttcatatg 467581 tcacatctcc ttttcaatgc cattttaata taaaataaaa aggaattaca tacaaatgca 467641 ttcaacatca gcatgcccaa aaataattag atcattttcc ggtgaaaatg ataagatagt 467701 aaagatgaat tgtagtgggg ggagtatcca ttgaaaacaa gtctaggatt agtgtacgga 467761 ggaaagtcgg cagaacataa tgtttccctg cagacagctc tggctgtaat caaagcgcta 467821 aatactgaga agtttgatat acatccgatt tatataacag aaaaaggcga atgggttaga 467881 ggcgcccgtt taactgaacc tgtttcaaac gtgaaaatgc ttcaatttga gcaaggaggc 467941 agtgcttttt ctccagctgc cctgaaccag gagatgtttc cgcaggaagc gtcacagcaa 468001 aatgaagcca tcgacgtcgt attcccgctc ctccacggac cgaacggaga agacggtacg 468061 atccagggaa tgctcgagct gttgaacatt ccttatgtcg gcaacggagt gcttgcttcc 468121 tcagctggca tggataaagt tgtcatgaaa catttatttg cgcaggttgg ccttgctcag 468181 gctaaatacg cagctttcct taagaaagac tggactcgtt ctccgaaaga aagctgtgag 468241 gaggttgaac aggaattagg ctacccttgc ttcgtaaaac cggcgaacct cggctcaagt 468301 gtcggaatca gcaaatgccg aaaccgtgaa gaactgcaaa aagcgtttga gcttgctttc 468361 caatatgacc gcaaagtcgt cgttgaagaa ggaattaacg gccgcgagat cgaaatcggc 468421 gttcttggaa atgatgatcc taaatgctct gttgtgggag aaatcgcacc gaagacagat 468481 ttctacgatt acaaagcgaa atatgaggat ggagatactg atctgatgat tccggcgatt 468541 gtgactgatg aggaatacgc aacaatcagt gatatggcga tcaaagcgtt taaagcgatc 468601 gacggttcag gactcgtcag agcggacttt ttcctgacag ctgacggcga agttctgatc 468661 aatgaagtca acacaatgcc tggctttaca cctttcagca tgttcccgtt gctctggaaa 468721 gaagccggag tggaatatgc tgacctgatt gaacagcttg tggagcttgc aaaagaacgc 468781 cacgctgaaa aacaattgat taagcataca ttctaatgaa gaaggacact gccggtaaaa 468841 gggcagtgtt ttttcccgta tatacaaaag aaagagaggg accttacttg attaagcgaa 468901 cagtaaaaaa cattgccgaa atggttaaag gcacactagc aaatccgcaa tatgaacaaa 468961 cagtcattca tggagtggca accgatacaa gaaaactgga acaacatcag ctctttattc 469021 cgctgaaagg ggaacgtttt gacggccact cttttgtgga gcaggccttt gaagctggtg 469081 tagcggctgt tctttgggat cggtcagtac caaatccgcc cgagaatcac gccgtcattt 469141 tagtggacga tacccttact gcacttcagc agcttgcaaa agcttatttg caggagcttg 469201 gcacgcgtgt catcggagta accggaagca atggcaaaac gacaacaaaa gatatgattc 469261 acgccgtatt ggggacccag taccgtgtcc acaaaactgg aggaaacttc aataatcata 469321 tcggtttgcc gctgacggtt ttagcgatgc ctgaaaatac ggagatcgcc gtattggaga 469381 tgggaatgag cgccaaagga gaaattgacc tcttgagccg actggcaaac ccggatgcgg 469441 cagtgattac gaatatcggc gaatcgcata tgcaagacct cggctctaga gagggcatcg 469501 cggaggcgaa gcttgaaatc ataaacgggc ttaaagaaga cggagtgctg atttatatcg 469561 gggacgaacc gcttcttcaa aatgcataca gctgccagac gaaaacgtac ggtacgggaa 469621 cgcataatga ttatcagctt caggatgtca gccagagtga ggaaggaacc cattttacaa 469681 tcaaagggat agaaaacacg ttttttattc caatactcgg caagcacaat gtgatgaacg 469741 ccatggctgc aattgctgca ggggcttatt ttggcatcgc gcctgaggat gcggcaaaag 469801 gactgagcgg cctaaaggta accgggatga ggcttgaact catcaaaaca gacagcggcc 469861 tttcgataat caatgacgct tataatgcga gcccgacttc catgaaagct gcaattcaat 469921 tgacagaaag ccttgaaggc tacggcaaaa aaatgctcgt gctcggtgat atgcttgaac 469981 tcggcgatct tgaagaaacg ttccataaag agtgcggcgc tgtgatcagc cctgataaaa 470041 ttgaccgcgt ctttacgtac ggaaaactgg gagcttttat cgcggaaggc gccctgaaac 470101 actttgagaa agaccgcgtc agccattaca ctgagaaaaa agatctcctt caagctgtga 470161 aggaaaacgc atcaaaaggc gatttgattt tattcaaagc gtccagaggt atgaagcttg 470221 aagaaatcgt taaagattta atagagagcc cgctttcata agaaaatatt ttgcgaaaaa 470281 acgcatattg catcataaaa taacctgata tgcaaacact aatgtatgcc ggccgaaaat 470341 tatgtatatc tggccggctg cggctatgat acaatatata taggttattt cgcgatacga 470401 acatattcgt ccggactttt catcgtgacc cgaagttctc cgctggattc ttgggagcgg 470461 atggagcagc agccggcata ttcgagatgc cgatctgctt ctcatcttat tgaaaaacaa 470521 atagtgtaat ggtaagataa aacttaaagt aattcgggct ttgtatacgg atggatcctg 470581 tccttcttgt ctaaagggca gttttataag tggtaaatca cgacattact gaaacagcaa 470641 ttagaaggag tttgaataat ttgactataa cgtttcaaga ttttaattta agttctgatc 470701 tcatgaaagc aattaatcgt atgggatttg aagaagcaac accgattcag gcacaaacga 470761 taccgctcgg actttcaaat aaagacgtca ttggacaagc gcaaacaggt acaggtaaaa 470821 cagctgcgtt tggtataccc cttgttgaaa aaattaaccc cgagtctcct aatattcaag 470881 caatcgtaat cgcgccaacc cgtgaattag ccattcaagt atctgaagaa ttgtataaaa 470941 tcggacaaga taaacgtgcg aaggttcttc ctatttacgg cggacaggat attggacggc 471001 aaatccgggc gttaaagaag aatccgaata ttattgtcgg aacacctgga cgtcttcttg 471061 accacatcaa ccgccgcacc attcgtttaa acaatgtaaa taccgttgta atggatgaag 471121 cggatgaaat gctgaacatg ggattcattg acgatattga atctatcctt tcaaacgtgc 471181 caagcgagca tcagacactt ctgttctctg ccacaatgcc tgcgccgatc aaacgcattg 471241 cagagcgctt catgactgag ccggaacacg taaaagtaaa agcgaaagaa atgacggttt 471301 ctaacattca gcagttctat ttggaagtgc aagaacgtaa aaaattcgat acactgactc 471361 gccttcttga tattcagtct cctgagcttg cgatcgtatt cggacgtaca aaacgccgtg 471421 tcgatgagct ggctgaagct ctgaaccttc gcggatatgc agctgaaggt attcacggtg 471481 acttaacgca ggcgaaacgt atggttgcgc ttcgtaaatt taaagaaggc gcaatcgaag 471541 ttctagtcgc aactgatgtt gccgctcgcg gacttgatat ctcaggtgtt acacacgtat 471601 acaacttcga cgtgcctcaa gatcctgaaa gctacgttca ccgtatcgga agaacgggcc 471661 gtgcaggaaa aacaggtatg gcgatgacgt tcattacacc gcgtgagaaa agcatgcttc 471721 gcgcaattga acaaacaaca aaacgcaaaa tggaccgcat gaaggagcct acacttgatg 471781 aagcgttaga aggtcagcaa caggttactg ttgaacgtct tcgcacaaca atcagtgaaa 471841 acaacctgaa cttctacatg acagcggcag ctgagctgct tgaagatcat gatgcagtaa 471901 cagtggttgc ggcggctatc aaaatggcta caaaagagcc agacgacaca ccggttcgct 471961 taacagacga agcgccgatg gtcagcaaac gctacaagaa ccagcgctct tctaaacgca 472021 gagacggtca aggcggcggc taccgcggcg gaaaagggaa aagcaacaac cgttcttcct 472081 atgacaaaaa gcgttcaaac gatcgccgtt cttcaggtga cagacgccag aaaaaatctt 472141 actaatttga tcgattcaga gcccaaaaca tgatgttttg ggctttttta tgttcgtgat 472201 ttgttattca gcaaactttc agctgacgga agccattttt ctctgtatgc ttaagaatga 472261 aacctttctg taaaagagac gtataaataa cgacgaaaaa aagggaggta ggtatttttg 472321 agagagcagc caaaaaacca aatcagtcca gacggattaa aggtttggcg acttcaagag 472381 atcatcatat ccgctgtttg cttgcttatt gtcattgcag ttgcagtgtt aagctattat 472441 tttcattggc cgtactggat cagcggcgtg ctcggcgctg tttggctgct gggatcgatt 472501 gtgacggtct ttatcattcc gaaggtccgt cataaggtgt ggcgatatga agtccatgaa 472561 catgaaatag atattcagtc aggtattttt gtggtgacac gtgtgattgt tccgatggtc 472621 agagttcagc acgtcgatac gtcacaaggg ccattattaa aaaaatacaa cctggcaacg 472681 gtgaaaattt ccacagccgc gaccgttcat tcgatccccg ctttagagat ggaggaagcg 472741 gatcggctaa gagactccat ttcccgtctg gcgagggtga ctgacgatga tgtctgaacc 472801 gaaacgcctg cacccggtgg cagtcatttt gaatttatgc cataccatta ttcaaacgat 472861 aaaaaatatc attctgccat tcttttttgt gtatattgtc aattcaaacc atactgtccg 472921 tttttacgga gccattgcgc tcggtgtgct gttcatctgg cttgtagcgg caagcattat 472981 caaatggaga aggtttacct atcgaattga agatgatgaa tttagaattg aagaaggctt 473041 atttgttacg aaaaaacgat acatatcgat tgatcggatt caaacaatga atacgagcgc 473101 gggccttgtc cagcaaatct ttaagcttgt gaagctgcaa attgaaacag caggcggagg 473161 caaggaggca gaagccgttc tttctgctat ttctgttgaa gaagcggaac gcatcaaaga 473221 agctgtcttt aagaaaaaag cgcaaagacg agaaaatgaa cttgatgaag aacggcttga 473281 agctgaagag gagttggatc cgtccgttga ggtgcaagag cactatcgca tgaacgcgaa 473341 agaattgctc atggccgctt ctacctccgg cggaatcgga gtcattatct ccgctgtatt 473401 tgcacttatt tcccagcttg atgaagtgct gccgatggat tggttattcg ataaattttc 473461 cttccttcag cacgccagca tcggtattta tgcggtactc atttttatcg gtttatttat 473521 cgcctggatt ttcagcatcg cgggcatgat gtttagatac gcgaactttc aaatcataaa 473581 aaaagagcag gaactggtga tttcaagggg aattattgaa aaacatcaag tcacgattcc 473641 gctgcgaaaa atacaagcca ttaaaatcaa agaaaatatc attcgccagc ttttcggctt 473701 tgtaacggtg tccatcgtca gcgcaggagg cggcgaccgg gaaaaagaag aaggcgcttt 473761 gaccattctc tttccaatga ttcataaaaa aaagcttccg cacatgctcc gaacatttac 473821 gccggaatac acgctggaag aaaactgccg ccgcctgccg cggcgcgcgt tgaaacgcta 473881 tttgttccgt tctgtcattt tttcactctt tttgatcatc ccgttatgta tcttctttca 473941 gccatggggc tatctgtcag tgatcctgct gccgatagaa ttgctcttcg gctatctcgc 474001 gtataaagag gctgcatgga cgatcaacgg ggaccgtctt cagctgacgt ctagatttat 474061 aggcagaaca accgccattg tactgaaaaa acgaatgcag gtctgcaagt tcagccaatc 474121 ctatttccaa aagaaaggcc gcttgtatac catttctact tcggtgaaat catcgagcca 474181 tatggaagag ttaacggtga gggacgtagg tgaagaggat gcagccttca ttttaaagtg 474241 gtactcatat gaaaaagcgg acggttaata ccgccgctcc agcgtgtcgg caaaccctcg 474301 cattcgttgt caggactgcg cttcggtgct caatgcgaag tggatcaacg gctaaattct 474361 caggcgtcct gcctaaacgc cgtcgtcatc acatcctgtg aaagtccgct cctatgctcg 474421 tccttcctag acttcatggg ttttcaatca cgctgaaaag atgacaaaat cctaaaatga 474481 aaaccatttt aggattttgt caacaatctg aagcggcggt taataccgcc gctctttttt 474541 ttgcacgcat aaaaacgaaa gaagaaaccc gccgcatagt ccaaacaaat gggccatcat 474601 gttaatattg gagttgataa acgacatgag aacggcaaat gcgagcagtg tgatgatcat 474661 tttggaatgc tcctgcccaa ttaactcatt gcgaaaaaga accataaaca ggtatacgcc 474721 aaatagcccg aaaatggcgc ctgaagcccc gacatgcacg taatcaagcg gctctgtaac 474781 ataagtgccg atattgccga tgatgccgga gccggcgtat acaagaagga aacgcgcttt 474841 tcccagcatg cgttccaaag ccggggcaaa taaaaagatg gacatggaat taaacagcag 474901 atgtgtgaaa ccggcgtgca gcaaaatcgg tgtgataagc cgccaccatt caccgtttgc 474961 gacacctaga ttatagcctg tgacggtatc cctccataac acgactgaat gggcaggaag 475021 tgaaaaaaac agccagagaa cagcttgcaa agccaatata aaggtgacaa cggggtaaag 475081 cctgataaat gtttgaaaat tttcagtccg tataaacatt ccgagcccct tttcttcatt 475141 ttggtatatc tatagtaaca cgtttatgag acaaaccatt taaatagtac gtacgcaaag 475201 gaggttatca tacatgattt acggcattgg gctggacatt accgagctta aacggatcgc 475261 ctctatggct gggcgccaga aaaggtttgc cgagcggatt ttgacgcgaa gcgagcttga 475321 ccaatactat gagctttcag agaaaagaaa aaacgaattt ctcgcgggca gattcgcggc 475381 aaaagaagcg ttctcgaaag catttggcac cggcattggg aggcagctca gctttcagga 475441 cattgaaatt aggaaagacc aaaatggcaa gccctatatc atttgtacga aactgagcca 475501 ggccgccgtt cacgtatcga tcactcatac aaaagaatac gctgccgcgc aggttgtgat 475561 tgaaaggttg tcaagctagt ctgcatatta gggaaacccc actcatatat ttgatagtgc 475621 attaagggag acaagttgtt tgaggctttt atggtacgca tctgttctgc ctaaacgtgt 475681 accgagcgta ccgttaaagt caaacaagcg atttcttcct tttacatcaa ttgagaaaaa 475741 ggggttgaaa aaggtgagaa aaagctttgt tttgctttta acgggactgc ttgctgttct 475801 tattctttct gcctgcgggc aaaaaacaca gcaagatatt gtggccgggt tagatgaaaa 475861 ggcgaaagaa tacacctcgt acaaagcaaa agcgaaaatg accatcgaga cagggagtga 475921 gcctcaagta tacaatgtgg aaatctggca caaaaagccg tctctgtaca gggtttattt 475981 agaaaatccg aaaaaggacc aaaaccaagt cattttacga aatgaaaacg gagtattcgt 476041 tctcacgccg tctttaaata agagcttcag atttcaaagc gattggccga acaacagcag 476101 ccaggtttat ctgtttgaat cgctcgtaaa ggatgttcaa aacgattcgg atgcagtttt 476161 cacagcgaaa gaaaagaaat acgtatttga aacaaaaaca aactatcagc ataacaaaat 476221 gctgcccacg caagaaatca catttaacaa aaaagatatg agcccgtcat ctgtcaaagt 476281 gatggatact gaccggaaag tgatggtcaa agtagaattc agcagctttg aatttaataa 476341 acaatttgat aaagaatcat ttgatgaaaa gaaaaatatg accctttctc aaatggatgt 476401 cgccacaagc gcaaagcctt ccgatacatt tgcggtcaaa acgccgctgg aactgccgct 476461 tggcgtcaag ctgcttgaag aaaaagatat atctactgaa gacgggaagc gcatcatcat 476521 gacgtacgga ggagaaaaat catttacgtt aattcaggaa aaagcccaga ttgccaaggc 476581 ttcctcctcc gttacgctga acggcgaacc ggtaaatctc ggctacacca tcggcgccct 476641 gtcggatgca tcattatcat ggacatatga cggcgtagat taccttctct cttctaaaga 476701 tctttctaaa gaggaaatgg tgacagtagc gaaaagcatg cagggacaat catcgaaata 476761 accgccaaag gccaaacatg atttggcctt tttttcgtta gacatcgttt ccctttagcc 476821 tttaatttta gtatgatatg taaatgatat tgaataaaag ctaggaagtg tcgtaatgag 476881 cacaaaacct ttttacagag atacgtgggc ggaaattgac ttgtccgcga taaaggaaaa 476941 tgtcagcaat atgaaaaaac atatcggtga acatgtccac ttgatggcag ttgtgaaagc 477001 aaacgcctac gggcatggtg atgcagaaac agcaaaggct gctcttgacg caggtgcttc 477061 atgcttggcc gtggccattt tggatgaagc gatttcactg cgcaaaaagg gattgaaggc 477121 gcctatattg gtgcttggcg cggttccccc ggagtatgtg gcaatcgctg ctgagtatga 477181 cgtgacctta acaggttatt ctgttgaatg gcttcaggag gcagcccgcc acacgaaaaa 477241 aggttctctt cattttcatc tgaaggtcga tacggggatg aacagacttg gtgtaaaaac 477301 agaggaagaa gttcagaacg tgatggcaat tcttgaccgc aaccctcgtt taaagtgcaa 477361 aggggtattt acccattttg cgacagcgga tgaaaaagaa agaggctatt tcttaatgca 477421 gtttgagcgc tttaaagagc tgattgctcc gctgccgtta aagaatctaa tggtccactg 477481 cgcgaacagc gccgctggac tccggctgaa aaaaggcttt tttaatgcag tcagattcgg 477541 catcggcatg tatggccttc gcccgtctgc tgacatgtcg gacgagatac cgtttcagct 477601 gcgtccggca tttaccctgc attcgacact gtcacatgtc aaactgatca gaaaaggcga 477661 gagcgtcagc tacggagccg agtacacagc ggaaaaagac acatggatcg ggacggtgcc 477721 tgtaggctat gcggacggct ggctccgaaa attgaaaggg accgacatcc ttgtgaaggg 477781 aaaacgcctg aaaattgccg gccgaatttg catggaccaa tttatggtgg agctggatca 477841 ggaatatccg ccgggcacaa aagtcacatt aataggccgg cagggggatg aatatatttc 477901 catggatgag attgcaggaa ggctcgaaac cattaactat gaggtggcct gtacaataag 477961 ttcccgtgtt ccccgtatgt ttttggaaaa tgggagtata atggaagtaa gaaatccttt 478021 attgcaggta aatataagca attaacttac ctaaatggag aattcataaa acagctttgc 478081 ttgaagagtg aataatggta tcattatcac tggatggata aaagagtcgt atccgtaagt 478141 ttggtggagg tgtatgtttt ttgtctgaat ccagcgcaag aaccgaaatg aaaatcagct 478201 tgcccgaaaa cctagtagct gaattggatg gtgtagcgat gcgggagaaa cgaagcagaa 478261 acgaactgat atcacaagca gtgagagcgt atgtcagcga acgaacaact cgtcacaacc 478321 gtgatttgat gagacgcggc tatatggaaa tggcgaaaat caacctgaat atttcttctg 478381 aggctcactt tgcggagtgc gaggctgaaa cgacagttga gcgcttagtc agcggaggat 478441 aatcatttga ttgtgaaacg cggcgatgtt tattttgctg atttatctcc tgttgttggc 478501 tcagagcaag gcggggtgcg cccggtttta gtgatccaaa atgacatcgg aaatcgcttc 478561 agcccaactg ctattgttgc agccataaca gcacaaatac agaaagcgaa attaccaacc 478621 cacgtcgaaa tcgatgcaaa acgctacggt tttgaaagag attccgttat tttgctggag 478681 caaattcgga cgattgacaa gcaaaggtta acggataaga ttactcatct ggatgatgaa 478741 atgatggata aggttgatga agccttacaa atcagtttgg cactcattga tttttagaca 478801 tatttgcagg ttgctcaaat agagcaactt tttttgtttt caaaaaacat aaacgatata 478861 atagtgaaat aacgaaaaaa tatgttgttt tttattggga ggtaagcgaa tttgatgtcg 478921 aaccagactg tataccagtt cattgccgaa aatcaaaatg aactgctcca actgtggact 478981 gacacactaa aagaattaag cgagcaagaa tcctatcagc tgactgacca agtgtatgaa 479041 aatatatcta aagaatatat cgacattctg ctgctgtctg ttaaggacga aaatgctgct 479101 gaaagccaaa tcagcgaact ggcgcttcga gcggtccaaa tcggactgtc tatgaagttt 479161 ttggctactg cacttgccga attctggaag cgtctctaca cgaaaatgaa tgataagaga 479221 ttgccagatc aagagagcac ggaattaatc tggcagattg atcgcttttt cagcccgatt 479281 aacacagaaa tttttaatca atactcaatc tcatgggaaa aaacagtatc cctgcaaaaa 479341 atcgcgctgc aagagctgtc tgcgccgctt atcccggtgt ttgaaaatat cactgtgatg 479401 cctcttgtcg gaacaattga taccgaacgc gcgaaacgaa ttatggaaaa ccttcttaat 479461 ggcgtcgtca aacaccgttc ccaagtcgtg ctgattgaca ttacaggtgt ccctgtcgtc 479521 gatacgatgg ttgcccatca tattattcag gcatcagaag ctgtaaggct tgtcggagca 479581 aaatgcctgc tggccggaat ccgtccggaa attgctcaaa caatcgtcaa cctggggatt 479641 gatttatccc aagttataac taagaatacc ctgcaaaaag gaattcaaac agcattggaa 479701 atgacggatc gaaaaatcgt ttcattgggg gaataacatt ttgagacatc cgaaaatccc 479761 gatcttgaaa ctgtataatt gcttattagt gtccattcag tgggaacttg atgaccagac 479821 agcattaact tttcaagaag acttattaaa taaaatatac gaaacaggtg ctaacggagt 479881 cgtcattgac ctgacatctg tggatatgat tgattcattt atcgcgaaag tgctggggga 479941 cgtcattaca atgtctaagt taatgggggc taaagtcgtc ttgaccggca ttcagcccgc 480001 tgtggcagtg acgctgattg aacttggaat cgcgcttgag gaaatcgaaa ctgcgctcga 480061 cttagagcag gggcttgaga cattgaagcg ggaattgggg gaatagcgaa tgaacgacca 480121 atcctgtgta agaatcatga cagaatggga tattgtggcc gccagacagc tgggacgaaa 480181 cgttgcgaaa gaactgggtt tcggcacggt agaccaggct agaattacaa cggctatttc 480241 agaattagcc aggaatattt atttatatgc cggcaaaggg cagattggaa ttgaacaggt 480301 cgcagacaga ggaaaaaaag gcctgaaaat catagcggaa gaccaagggc cgggaattcc 480361 tgatatccga aaagtcatgg aagacgggtt ttcaacgtct ggaggacttg gtgcgggact 480421 tcccggggtc aaaaggctga tggatgaatt cagcttaaat tccgtagcgg gggaaggaac 480481 agagatacaa gccatcaaat ggcttcggta ggaggtaaga acgtggattt tagggaggtt 480541 attgagcagc ggtatcatca gctgcttagt cgatatatag ccgaattaac agaaacatct 480601 ttatatcaag cccaaaaatt cagccgaaaa acaatcgagc accaaattcc tccggaagaa 480661 atcatcagca ttcacagaaa agtgctgaag gagctgtatc caagtctccc ggaagatgtg 480721 tttcattcgc tggatttttt aatagaagtc atgattggct atggaatggc ttatcaggag 480781 catcaaaccc ttagagggat acagcaggaa atcaaatcag aaattgaaat cgcggcaaat 480841 gtccagcaga cgcttctcgg aactaaagtt cctcaggagg aagcgctgga tatcggcgcc 480901 atcagtgttc ccgctaaaca gatgagcggt gattactacc actttgtcaa agacaaggaa 480961 tccatcaata tcgcaatcgc ggacgtgatc ggaaaaggca ttccagcggc tttatgcatg 481021 tccatgatta aatacgcaat ggactctttg ccggaaacgg gcatacaccc ttctcaagtg 481081 ctgaaaaatt tgaatcgtgt tgttgaacaa aacgttgatg ccagtatgtt tattacgatg 481141 ttttatgcga attacaatat ggacaagcat caatttacat atgcttcagc gggacatgaa 481201 ccgggattct attattctca aaaagacaac acgttttacg atttagaggc caaaggactc 481261 gttctcggca tctcgcagga ctatgactac aaacaattcg atcagcatct ggaaaagggc 481321 gatatgattg ttttattttc tgacggcgtc acagaatgca gaacggaaaa cggtttcttg 481381 gagcgtcctg atctgcagaa gctcattgag gaacatatgt gttcctctgc gcaggaaatg 481441 gtcaaaaaca tttatgacag cctcctcaaa ttgcaggatt ttcagcttca cgatgatttt 481501 acgttaattg ttttgcggag aaaggtttaa cgtctgtcag acgagggtat aaagcaacta 481561 gtgatttgaa ggaaaatttg aggtgatacg aatgaatata aatgttgatg tgaagcaaaa 481621 cgagaatgat atacaagtaa acattgcagg agaaattgat gtatactcag ccccggtgct 481681 tagagagaag ctcgttcctc tggcagaaca aggagctgac ttaagaattt gcctgaaaga 481741 tgtcagctac atggacagta ccggattggg cgtttttgta gggaccttta aaatggtgaa 481801 aaaacaaggt ggttcgctga aacttgaaaa tctttctgaa cggctgatcc gactgtttga 481861 cattacaggc ttgaaggaca tcattgatat ttctgcaaag tcagaaggtg gagtgcaatg 481921 aagaataatg ctgattacat cgaaatgaaa gtgccggccc aacctgaata tgtgggaatt 481981 ataagactga cgctgtcagg ggtcgcaagc agaatgggct atacgtacga tgaaattgaa 482041 gacttgaaaa tcgcagtcag tgaggcgtgc acaaatgcgg ttcagcacgc ttacaaagaa 482101 gataaaaatg gggaagtgtc aatacgattc ggtgtgtttg aagaccgttt agaggttatt 482161 gtggcggatg aaggagacag ctttgacttt gatcaaaagc agcaggatct agggccgtac 482221 acaccttcgc acacagttga tcaattatca gaaggagggc tcggtctata tttaatggaa 482281 acgctcatgg atgaagtcag agtgcaaaac cactccggcg tcaccgtagc gatgacaaag 482341 tatttaaatg gggagcgagt tgatcatgac acaaccatca aaaactacga aactaactaa 482401 agatgaagtc gatcggctca taagcgatta ccaaacaaag caagatgaac aagcgcagga 482461 aacgcttgtg cgggtgtata caaatctggt tgacatgctt gcgaaaaaat actcaaaagg 482521 caaaagcttc cacgaggatc tccgccaggt cggcatgatc gggctgctag gcgcgattaa 482581 gcgatacgat cctgttgtcg gcaaatcgtt tgaagctttt gcaatcccga caatcatcgg 482641 tgaaattaaa cgtttcctca gagataaaac atggagcgtt catgtgccga gacgaattaa 482701 agaactcggt ccaagaatca aaatggcggt tgatcagctg accactgaaa cacaaagatc 482761 gccgaaagtc gaagagattg ccgaattcct cgatgtttct gaagaagagg ttcttgaaac 482821 gatggaaatg ggcaaaagct atcaagcctt atccgttgac cacagcattg aagcggattc 482881 ggacggaagc actgtcacga ttcttgatat cgtcggatca caggaggacg gatatgagcg 482941 ggtcaaccag caattgatgc tgcaaagcgt gcttcatgtc ctttcagacc gtgagaaaca 483001 aatcatagac cttacgtata ttcaaaacaa aagccaaaaa gaaactgggg acattctcgg 483061 tatatctcaa atgcacgtct cgcgcttgca acgcaaagct gtgaagaagc tcagagaggc 483121 cttgattgaa gatccctcga tggagttaat gtaatgatcc aggttgaaga aaacgagcat 483181 attcaaactc tagtatatca actgaataaa gaagggaaat cgatttgcgg tgacagtttt 483241 tttatgaaag ctgatgataa ggagttaatt tgcgcggttg ctgacggact gggaagtgga 483301 tcacttgcta acgaatcctc tgcagccatc aaagacttag tggaaaacta tgcgagtgaa 483361 gacgtagaaa gcattatcga acgctgtaat caggcgatga aaaacaaaag aggcgctaca 483421 gcatctatcc tgaaaatcaa ttttgagcaa aggcagttta cgtactgctc tgtcggaaat 483481 gtacggttta ttctgcattc cccgtctggt gaaagctttt atcctctgcc gatttcgggc 483541 tatttatcag gcaagccgca aaaatacaaa acgcacaccg ccacctatga aaagggttca 483601 aagttcatta tacatacaga tggactcaac gtacctgata tccgctccca tttgaaaaaa 483661 ggccaatcgg tagaagaaat atcgaattcg ctgaaaatgt atacgacatc gagaaaagat 483721 gacctgacct atattctcgg acagctgtcc taaaaaacca gaaaaagaag ctggacatcc 483781 ggcttctttt ttttgcggtt gactattaat aagtgcgctt attatactta ataagtgaac 483841 ttatcattct gggagcttat gggatgtgga attatgaata cacagcgata gctgatgtgg 483901 atgtgggaaa acctggaact gttatcagga aacagaaaca atggatcaat gggagacggg 483961 tattgcatca gattctttga aaggacaatt tcaaaatgga acggaaggaa cattgcttct 484021 gcaaggaaaa acaattctct tatggcttga gcatgtggag aaacatcggg cgttttctgt 484081 catggtcaac atgcccgcat agcaatgtaa taatggagtt ttttcacgtg cttcaaaagc 484141 aaaaagaaga tttgtgtatc acatatggaa ttgtattaga aggcgctgaa gcaaaaaagt 484201 ggggagaaat cattgggact gaactgtcta aagacatgcc gacggctgtc agcaggcttg 484261 tccatcttta cggaggagtg ataaaatgaa cacaaattac tggatcggcg ttgtgtcaga 484321 gcaacatgta ttaaaaggcg ctgccggcgg ttttgcacag ctgtgccatg gaaaaaaagc 484381 cccgctcgcc aaaatgaaag agggagattg gctgatttat tattctccga gagacgcata 484441 tccagacggc aaactgctgc gaagctttac tgcgatcggc aaagtaaaaa gcggaaacat 484501 ctatccgtat caaatggctc cgaattttat tccataccga ttagatatag actattatcc 484561 atgccataaa atcggttttt acgacattaa atcaaagctt gaatttgttc aggaaaccaa 484621 gcatcttggc tttttatttc gcagaggaca ctttgaaata agcaaaaaag attttttgac 484681 aatagcacaa gcgatgggag ttaacataag tggaatggca ctctaaattt agcggtccga 484741 acacaagccc gggcttttta ttatggcagg ccacgcaaag ttggcagcgg aaagtaggaa 484801 aagcattggc tgagtttgac ctgacccacg ttcaatttgt tctgctgacc tcgtgcaagt 484861 atatgattgc tcacggagaa accgtcacgc aaaaaaaact tgcaagcttc agccagacca 484921 atatcatgat ggtttcggag gttgtgcgga cgcttgagaa aaaaggattt atcgaaagaa 484981 gcaaaaatcc ccaggataaa agagaggtcc tcctgtctct tacagaaata ggaggagaaa 485041 aagtaacagc ggctttgcca attgttgaga agattgatca agccttcttt gcagctgcga 485101 tgaaaaaaga gaattttctg agcggcttac aggaactatt gaaacatgag taaagatacg 485161 ggcagcgcca gctgtctttt tttatgtgtt tttttcggtt tttgatacac tagagaaaga 485221 acgacaaaat tggaggcttt ggttacatgg aaacgtcagc ccttttaaaa cagcaaattg 485281 cgaaagaaat aggtttatca caaaaacacg ttgaaagtgt catccgcctg cttgaggacg 485341 gcaatacagt cccgtttatt gcccggtatc gaaaagagca gacgggttca atggatgagg 485401 ttcagattca gacgatttct gaacgctggc aatacataca aaacctgaat cagcgaaaag 485461 aagaagtcat caggctgatt gcagagcagg ataaactgac agataatcta aaacgtaaaa 485521 tcgagcaatc ggtgaagctt caggaagtgg aagaccttta ccgcccttat aaacaaaaac 485581 gtaaaacaaa ggcgacagtc gccaaaagca aaggccttga gccgcttgcc gactatatcc 485641 tgacacttcc ccaagatgat catctggcag caactgcaga ccaatacatc agcgaagaaa 485701 aagaagtgtt cacacgagaa gaagcgattg aaggcgccaa gcacattatt gcggaacaaa 485761 tctcagacga gccgaccttc agaaagtgga ttcgccagga aaccttcaaa agaggaacca 485821 ttaagtctgc agccggaaag tcggcagaca ccgatgagaa aaatgtgtat gaaatgtatt 485881 acgagtatga agagccaatt gcaaaagttg ttccgcatag ggtgctggca atgaaccgcg 485941 gcgaaaaaga agacatttta aaggtagcga tcgaaccgcc tgcggatcac attaaggcgt 486001 atttagaaaa acaaatcatc aaaaatcgct caacatccgt aagagagatt ttgcaggaga 486061 caattgaaga cagctataaa aggctgatcc agccggcaat cgagcgtgaa atcaggaaag 486121 agctctcaga aaaagctgat gaacaggcga ttcatatttt ctcagagaac ttgagaaagc 486181 ttcttttgca gccgccgatg aaaggcaaaa ccgttctcgg tgttgaccca gcctttcgaa 486241 ctggctgtaa gctcgctgtg tcagatgaga ccggaaaagt cttgaaaatt gatgtgatct 486301 atccgcatgc gccagtcaac aaaacaaaag aagcccatga aaaagtgaaa aagattcttg 486361 agcagtatca agtcgagatg gtggcgatcg gaaacggcac agcatccaga gaaacagagc 486421 aattcatcgt caatgtactc agagacatgc cgcgcaaaat ttattatgtg atcgtcaatg 486481 aagcgggagc aagcgtctat tcggcttcag agcttgccag agaagaattc cctgacctta 486541 aggttgaaga gcgcagtgcc gtatctattg ctcggagact tcaagacccg ctcgcggagc 486601 tcgttaagat cgatccgaag tctgttggtg tcggacagta tcagcatgac gtcagccaaa 486661 aacgcttaaa tgaatctctg cggtttgtcg tcgaaactgt cgtaaaccag gttggagtaa 486721 acgtcaacac agcctccgcc gcgctgcttc aatatgtagc tggattatcg aagtctgtag 486781 caggcaacgt tgtcaaaaaa cgtgaggaaa tcggaaagtt ttcaaatcga aaagaactga 486841 aggacatccc aaggttaggt gcgaaaacct atgagcaatg tatcggtttc ttaagagtgc 486901 aggaagggac agagcctttg gatagaacag gcatccaccc ggaaagctat aaagaaacaa 486961 aagcactttt gaaaaaactc ggactttcaa cagaacatat cggcacggcg gaattgaagg 487021 acaaaatcaa tcagctggcg ctctctgaaa cggcaaaaga gctgggaatc ggcgaaatca 487081 ctctgaaaga catttgtgaa cagctgacaa ggccggaacg cgatccacgc gataaggtgc 487141 ctaagccttt gctgaaaaca gacgtccttc agctggaaga tttgaaagag ggaatggaac 487201 tgcagggcac cgtgcgcaat gtagtggact tcggagcgtt tgttgatatc ggagtcaaac 487261 aagacgggct tgtgcatatc tcaaaattga gcaatcaatt cgtcaagcat cctcttgatg 487321 tcgtatctgt cggcgatatt gtgacagttt gggttgacgg cgtagatgta caaaaaggca 487381 gagtatcgct gtctatggta aaataaaagc actgcttacg agcagtgttt tttcctatag 487441 aaataccagc attgattcag cagtttaatt tggtaattat ctttttcaag gaacgctttt 487501 tgcatctgct ttttaagcca atttggcata ggctcattcc tcctcagctt ttatcataag 487561 agggacagtg attaccatat tgtatgcgaa cggtgaattg tcccgttcaa tgttttttaa 487621 gtgaggtgca ccatggataa caaagagctt caaaagctga cagaggatat ttctgaaaca 487681 tattttaaaa agccgttccg ccatcaggcg ctttttaatg accggcttaa aaccactggc 487741 ggcaggtacc tgttaacctc ccataacatt gaattgaaca gaaaatattt gattgaacac 487801 ggcagggagg aactgattgg catcatcaag cacgagctct gccattatca tcttcatctt 487861 gaaggaaaag ggtacaagca cagagacaga gattttagaa tgctattgca gcaggtcaac 487921 gcgccgaggt tctgtacacc ccttaagaaa aaagcggaaa acaaaaaaac ttatatgtat 487981 atctgtacga cctgcggcca acagtatata aagaagcgcg ccatgaaccc tgacagatac 488041 agatgcggaa aatgccgcgg aaaaataaaa agaatttttt cgtgaaaaag gttgacgaat 488101 atggcaagcc tatgttacat tataaaagtc gtcacgagag ataaataaaa acatttacct 488161 cttgacactg caaatcaagg ctgatataat aagtcttgtc tcattattcc acagtagctc 488221 agtggtagag ctatcggctg ttaaccgatc ggtcgcaggt tcgaatcctg cctgtggagc 488281 catattggag aagtactcaa gtggctgaag aggcgcccct gctaagggtg taggtcgcgt 488341 aagcggcgcg agggttcaaa tccctccttc tccgccataa gatttcgata taagttctca 488401 accatcggcc cgttggtcaa gcggttaaga caccgccctt tcacggcggt aacacgggtt 488461 cgaatcccgt acgggtcatt ccatttcgtt gggctatagc caagcggtaa ggcaacggac 488521 tttgactccg tcatgcgttg gttcgaatcc agctagccca gccattttta tttttgaaat 488581 ctaatagtaa gagccattag ctcagttggt agagcatctg acttttaatc agagggtcga 488641 aggttcgagt ccttcatggc tcaccatttg tctttttgcg ggtgtggcgg aattggcaga 488701 cgcgctagac ttaggatcta gtgtcttacg acgtgggggt tcgagtccct tcacccgcac 488761 tttatttaca aagtgcacgc aaatctgttt tactaggtta agagcctact aaaccagcac 488821 aacacaattt aatgatcacg cggtcgtggc ggaatggcag acgcgctagg ttgagggcct 488881 agtgggtgaa taacccgtgg aggttcaagt cctctcggcc gcatctcaat aataccaagg 488941 gtttaaccac ctttggtatt atttttttgt gtggaaaata cggctatggg agaagacttg 489001 ctcaccaaaa ctcaccagtt acttaaagta agtcatccaa acggtcggcg gttccttctg 489061 tttattagga aaaagatatc cgttcattgt aaaagaaacg aaccatgtcc tattcgttca 489121 aaaaaactaa agggtgatac atattataca tgattaatat gtatcaccct tttctttctt 489181 gttcaacaat cgcgcttgag gagaacataa gctaatacaa ctgactcgat ttctaaagtt 489241 gctccattct ttttttaaac aactcatcca caacctgttt taaaatctcg tacgactgaa 489301 tttccttgct caattcgtaa atattagata acacaattaa ttcatctgcg tgatacattt 489361 gttggaaatc aattagttcg cgacgaattg tttctcgatc acccatgatt gtatacccca 489421 gtcgactgtg gagaatttct aattcaaact gtgataacga ttctaggaag ttttcagtgg 489481 gtggaataag cttacttaaa ttatttgtat aaatatcaat atacacctgc aaatgacttg 489541 cagaaataaa agatgcctcg tctatagatt ctgctgcaat cacattaatg caagcgatca 489601 cataaggttc ttgtaaataa gaagacggtt ggaaattttc tcgataaata gagagcgctt 489661 cttccatcga atggggtgaa aattgagcgc caaatgcata gggtaaacca agctttgcag 489721 caatttccgc tgaatccgtt gaggatccta acacaaaaac aggcacatgc gttccaatac 489781 ccggataagc gcgaacctca ccctgtacac tcttatcccc gacaaaacgc aaaatatcat 489841 ttacttctct ttcaaagaaa aacactccat tatggttgga acgacgaatc acatcggccg 489901 ttttttgatc cgttccgggt gcgcgtccta atgccaaatc tacacgattt ggatataatg 489961 tttcaagtgt tccaaattgc tccgctacga ttaatgggga atgatttggc aacataatac 490021 cccctgaacc tacgcgaatg tcttttgtat ttgctaatat atgttgtaca attgatacgg 490081 ttgctgcact tgcataagcg tcgtgattat gatgctctgc aaaccaaatc cgtttatagc 490141 ccatattatc tacagcttta gctaatgaca ctgcagaatc aatcccttgt ttcattgttt 490201 ctccttgtct taatggagca actgataaaa cagatatatc aaattttttc ataatttcac 490261 ctctaaaata atgaacttat acaagatcaa tggaaaaaac attttgaaaa attgtttcat 490321 attaaatggt gtccattcct ctttgatttg catgcaaata aatatatact ttctcaaacg 490381 atcaatacat aggcaaaata aagttatttc acaatttcac tttactttta aagttttaag 490441 caaacataaa aaaatgttca gtgaacaaaa tatgtaaaat acatcttatt tttcagaaag 490501 gatacaagaa aatgattgat gaaatagata aaaaaatact tgatgagctg tctaaaaata 490561 gtcgccttac aatgaaaaaa ttaggggaaa aagtacatct cactgcacca gcaaccgcat 490621 caagagtagt aaagttaata gacaatggca taataaaagg atgtagtatc gaagtgaatc 490681 aagtgaaatt aggcttctct atacatgctt ttcttaatat ttatatcgaa aaaatccatc 490741 atcaacccta tttagctttt atagaaacac aagataacta tgtaataaac aattataaag 490801 ttagtggaga cggttgctat ttgcttgaat gtaaatttcc ttcaaacgag gtattagatc 490861 aatttttaaa tgacttaaat aaacatgcaa actataaagt gtcgattgtt attggtaaat 490921 agttaacttt ataaaacgga gatgtgcggt catataacat gatatatatg ctctaaaaaa 490981 gccctaggtt ggatatggaa tttaccaagc tggggccttt ttatacatta taataacaag 491041 cgcattattc atcagacatt aatgaagtat tataatgctt ttttacttcc ttaatagaca 491101 aataaagctg atagtttcca tacttcaata aatcattcag aaggtgattt aaaacttctt 491161 gtgaatgaac cgttaccttc agaagataac atgcatctcc cgaaacacga tgagcttcgc 491221 taatttcatt acgagtagca ataaatttca ataaatcatc atgcatatat gcattcatga 491281 aaaagaagac aaaggctgta aaagaaaacc ccatcttcaa ttcatcaacc acaatcgaat 491341 atgctttaat gataccgtta tcctccattt ttttgatgcg attgcctacc gcttgtcctg 491401 tcatatgaat tttttcaccg atttctttcc attgtatccg agcattttta tttaataatt 491461 ggagaatttg aaaatcaatt gaatcaattt gcatagtaac tcctttcaca gtgaaaaagt 491521 tttacaaaat agtatttcat gagaccatcg aaaattcaat ggaaattata tatccttata 491581 cagtataaaa attttaagag gtgaaaaaat gacaacagct ttattagtga ttgatattca 491641 aaatgattac tttccaaatg ggaagatggc tttaacaaac ccagagaaag cagcacaaaa 491701 tgcggctaaa ctactttcac actttagaaa cacaggcgca cctgtctttc atgtacagca 491761 tatcacagaa ggtaacatcg ctcatttttt ccatccaaat acagaaggtg tcgaaattca 491821 tgagtcagta cgtccattag agaaagagac agtcattgta aaacatatgc cgaatagctt 491881 tttcaataca gatttaaatg gaaagctaca agaagaaggg gttaaagaat tagttgtttg 491941 cggtatgatg tcccatatgt gtattgatgc aacagttcgt tctgcagttg aacatggtta 492001 tgtatgccaa gtggtagaag atgcttgcgc aacaacaaca ttgcaaattg aagataaaat 492061 cgttcctgct gagcatgtcc attacgcatt tatggccgca ttaaatggtg tctatgcaac 492121 agtaaaaacc acagaggcat ttttaaaata aaagaatttc ctgcgcgaac ataacgtctt 492181 tcttttcaca agaaagatga ttcaacaact taaaaaagga tgttcagaaa aatacttctg 492241 gacatccttt attcattatc ttttattgtt tttcagtatc attattccca tctgataaaa 492301 gatcaagatg tcctgttttt gatccatagt aagaccatat acagggattg tttttgccat 492361 aaatatagat attgatgaag gtttacataa agcacctaat tgcttgattt actttaatgt 492421 tagatccctc aataactcca ttctcttcta atttctctac tctagctgta gctgctgggc 492481 atgttaaatg tactctctcc cagatctttc attgaattcg gctattatac ataatttctc 492541 tataattttt tatctgtttg atctatttga acgttaattc ctttcgaaaa taaagtcaaa 492601 gagttaaaac actttttttt atctatgtat tcgaacactg ctgatattat acacttaact 492661 ctgtcgatct aagacaaata aaaaaagaaa gtgagttgta aatatgaata ttacacaaat 492721 tcgaaatgca acaattgttg taaaatacgc aaataaaaaa tttttgatag atcctatgtt 492781 agcagagaaa ggtacgtacg ctactttccc tgaaacgatc agacaagatt tatttaatcc 492841 tttggtgagt ttgccaacat caattgataa cattctggat ggcgtagatg cggtaattgt 492901 tactcatcta cacctagatc actttgatga tgtggcaaaa aacgtattgc caaaaaacat 492961 caaaatgttt gttcaaaatg aagcagatgc aaaagaagta aaagcaagtg gtttcaaaaa 493021 tgtagaagtg ctacatcaag acactgtttt tgaagggatc caattagtaa aaacaaaagg 493081 tgaacatggc agaggggaag agttattaaa cttaatgggt gatgtttgtg gattagtatt 493141 caagcaccca agtgaaaaag ttttatatgt agctggggat acagtttggt atgatgctat 493201 cgaagacgag attcatacac atcaaccaga aatcattgtg gttaatggtg gagacaatca 493261 aagattagat ttaggttcac tcatcatggg aaaagaagac atctatgaag ttcacaaggc 493321 tgctcctcat gctaagatta tatctgttca tatggaagct gttaaccatt ggacactatc 493381 tagagaagaa ttaaaaaact ttagtaaaga aaaaggattc tcaagtaata ttttagtgcc 493441 agaagatggc gagtcttaca cattttaata tgaacaccga caaataaata gaagaagctc 493501 ataattataa aaactaatca tgagcttctt ctaataatga atattttaaa ttttaaatat 493561 atcgaaaatc ctaaatatac ggaataacaa aaatggaatg ttccaatgat gacaaaaaaa 493621 cttgaaaagc aacaaagatg tgtcgttagg aggtagaatt catggtaatg acaaaaaaag 493681 atacaaatat atcaacacag cagcctcttt ggttacaagg ttatattgat tcaccagaaa 493741 aacaaaacca actttataaa aaaacattaa aaatcttgat tttttcacaa atatttgggg 493801 gagcaggact tggagctggg ataacagttg gggcgcttct tgcacaagat atgataggat 493861 cggaaaatgt agcaggaatt ccaactgccc tctttacttt tggatctgcc gtagctgccc 493921 tgcttatagg agcatcctca caacgttttg gtcgcagagc tggacttgca ggtggtttcc 493981 ttataggcgg attaggtgct ataggtgtga taatcgcggc tttaattaac agcgttgccc 494041 tattatttgt ttctcttctt atttatggag caggtatggc ttctaatctt caagttcggt 494101 atgctgggac agaccttgca aatgagaaac aacgggcaac tgctgcaagt atggccttag 494161 tttctactac tttaggagct gtagtaggtc ctaacttagt taatacaatg ggggaatttg 494221 cagattcaat tggtgttccc aatttagctg gtccgtttat tatgtcagga gcagctttta 494281 taattgctgg aattattctc ttaatttttc ttcgtccaga tccgctgttt gtatcaacag 494341 ctattgcgaa tgctgagaaa aaagacgata aagtacaaat aggaggaagt ctaaaaaatc 494401 ctgctataga caaaaaagga ataatggtag gagctgtcat tatgatttta gctcaactaa 494461 tcatgacagc tattatgaca atgacaccgg ttcacatggg tcatcacggt catggtttaa 494521 gcgaagtggg attagttata ggactccata ttgcagcgat gtatcttcct tcaccattga 494581 ctggtttatt agtagataag tttggtcgca caactatggc tattgcttca ggtgccacac 494641 ttcttgccgc tgggttggtg gcagctattg caccggcaga ctcattatca ttgctaatcc 494701 tagcactagt attactaggg gtaggttgga actttggttt actaacggga actgccctta 494761 ttatagattc aacacatcca tctctacgtg caaaaacaca gggaacattc gatgttttat 494821 tagcactatc aggagcagca ggtggagcct tgtcaggaat ggttgttgca cattctagtt 494881 atacaatact atcaatttct ggagccgttt tatcattgtt actcattcca gtagttattt 494941 ggtattttag aaggattcag gaaaaagcat aagcttatat aactgtcttt gaagaaccta 495001 agtagacatt actttaccgg aacctccttt ttctatttat tatagtaagg agttgacatg 495061 gcattagtgg catgtgtata actacacaat tatttgggat tcagagagca tgtaatgaac 495121 ggaagagata attatttatc acttttatta ttgtacggtg ttcttgtggc attaagttca 495181 gtcaattttg gtctaactgt tttctttttg ttttcatcac ctctccatat tattaacaaa 495241 cacgaaaagg attttaatga aaataaaatg attagcgtat gtatctctaa ttttcaaaat 495301 gaatgaatag tcctttttaa gatttacaca cttattctcc aaggaaaaat gactcaattt 495361 ttcgattttt tatgtaaatc aaaaaagaat catgttagag taggtgtgct gaaaataatt 495421 caaaaaatta ttttgcgata tgattaaagt aatattgcca gagagtttca attggacaaa 495481 attgtaagtg tttaatacac tggggctgca atcaaatatg cacctggaat caattgctaa 495541 acgggggagt ttatatgaac aacaagaaaa atatctttga tattgttatg tacattattt 495601 tcggtgtgtt aagtcttttt ctagttgcaa aaactgatta tggcactgga gttttagtgt 495661 ttgttgcaat tttatacctc gctgttattg cttataaaat taagcaagta tttagtaatt 495721 cagattctta aggtgtaaca caaggaggat ttcaattgag aaagaaaaga gttattactt 495781 gtgttatggc tgcatcattg actttaggct cacttttacc tgcaggttac gcttctgcaa 495841 aggaggactc taagacaacc ccttcttacg aagaactagc tctacattac aaaatgaaaa 495901 gtgaaaagat ttcatcgaac gggaaattag ttgaaattga gtatgtgagt ggaaatgaaa 495961 ctcacaaagt tcagatgaac ggaaataatc atactgtaaa agtcgatggc atagaacaaa 496021 aaggtttaaa ctttgagtat gatgaaaatg ttgctaaaag aacaaattat gaaaacaata 496081 atttgaaatc aaatgaattc acaacacagg ctgcaaaacc taaaaaggga taccattatg 496141 tggggacttt atctgggcat acaaaagcag ctaaaaatgc gttatcagtt acaatgtcat 496201 tagtcggtat tgtccctggc ttgggatggg ggagtaaggc tgccactatt ttattctctt 496261 attgggcaaa agaacaaatc cctgatgcgt attataaata tgatttatac gaaaaaggag 496321 caatgactga tagttggtat cagtatgcta cagttcaatt ttttgaagat aaagctcata 496381 aaaagaaaat gggcaaacct tggacaagta ctcctgcaaa agtagattta cctaatagct 496441 aattttaaaa tcactttgtc tttataaagg acaaagtgat tttttgttat acagaagtaa 496501 aatccctcgt ctgaggaatc ttggaaaaaa cttggttcaa ttttgatata acatgttttt 496561 ttcttgctaa tttagttttt ctatgtatcg ctacacattc taaataataa gatattagcc 496621 ggacggttga tgccaagctc aaaagtttat atggaagtca aagcataaaa aagggtgtta 496681 caacgtgtag tcttcttttt attttgccaa cgtaacaagt gtgaaagtaa tgatttgtag 496741 gatcagttaa gaaaggttta agattagata ttgaaaaatt ttatatattt tcaataaaat 496801 actggtacta taataaatgt atacagattg tatggagatg taattaatta aaaaggagtt 496861 ttttaattgc gttggagtaa atggttcaat gttttttgta tagtagcatt gggatcaata 496921 tatggttata aattatttac taaccaagaa gtcagtacta ctcgtttaat aatagcttct 496981 gtaattgtgt tgtggaatat tgttggactt tttagcaaag aatcagtaaa acaagcacag 497041 caagcaaatt aaaagtcata aagttgggaa agaaggatgt tacttatgta gtatccttct 497101 ttattattcc ttgaaaaatg aaacaaattg gagattacag cttatataat caattgaagt 497161 cgttgattat tttcatgaac aggagattta atgctttctg atgaaatatt atcgtatgaa 497221 tgttgcaaga ggaaacgtta ctcaaagatt acagggatgt gatgaacact cctctttatc 497281 gcactcacct gaccccaaat tgttggggaa gggcaggtac ggaagataga gtattttttc 497341 ttcgtaacaa atcgaaaagg ttggataata aaaaacttat aatctaaggc ggtatatagt 497401 tgtgaaaaag gcgttatttc ttatattaga ccagtatgca gattgggaag gtgtttactt 497461 agcatctgca ttaaatcaaa gagaagattg gtcggttcac actgtttctt tagaccctat 497521 tgtaagctca ataggtggtt ttaaaacatc tgtcgattac ataatagggt tagaacctgc 497581 aaattttaat ttgctagtta tgattggcgg ggattcctgg agtaatgaca ataaaaaact 497641 attacatttt gtaaaaactg catttcaaaa aaacattcca atagcagcga tatgcggtgc 497701 agtggatttt ttggcgaaga atggtttgct gaataatcat agccatacag gtaattttgt 497761 ttacttatgg aaagattaca aacaatataa accgattagc agttttgtag agaaacaagc 497821 agtaagagat aaaaatttgg ttactgctaa tggaactgcc cctattgaat ttactaattt 497881 aattttagag atgattgatt ttgatactcc tgagaacata gagaaaatga tgtatatgaa 497941 tcgttatggt ttttatcatt tttgtgataa atatggaaat ccatttgttg attaatttgc 498001 tggaaatgat tttcccgaat agggggcttt gcgattgagt tgaatttcct aataaagcaa 498061 agaaagatga tttgaggtca agtttaacaa ataatgccat caatattaat ttgcagttat 498121 ttccgattcc tgatataata aagaagaatt atttttgttc ggtgtaaagg atagtatgaa 498181 gattgacttt tcgtcttgat gatactttgg gcaaggatag tatatactgt gtggttacac 498241 actaggaggc aacaaaaatg gaacaaggta cagttaaatg gtttaatgca gaaaaaggtt 498301 ttggctttat cgaacgcgaa aatggagacg atgtattcgt acacttttct gcaatccaaa 498361 gtgacggatt caaatcttta gacgaaggtc aaaaagtatc gtttgacgtt gagcaaggtg 498421 ctcgtggagc tcaagctgct aacgttcaaa aagcttaatc ttcaatcgtt tatacaaaca 498481 ggctctttat atagggcctg tttttttatg tctatatcat actcaataaa aaaccctact 498541 caacgttcga gtagggagat gctacaaggt aatagaaaaa gatttaaaac ttcaaaggtt 498601 tgtttacagt ataacatact ggattgacaa tatgcggaat gtatataaat tatttaatgt 498661 tttgttcaaa tatagataac tgactctttt tttcactaac ctgttcgttc atttaagtaa 498721 gattagatga attataaaaa tggtttcatc taaatgttat caactcgcat atctctttta 498781 tgagaagaag ataaacaatt attattcaat gttgcagtgg atataagaaa ttcttaaaaa 498841 taatgaggag atcgattgtt tttttctcct ggaaataatc acttagagat acctaaaaca 498901 atgaaagccc tacctctctt ccatccttac ggctccttgt ccgtgccagt gtgaatcagg 498961 atactaaaaa aagtgactat tttattgagt tttttggtaa aacttcaatc ttcgcagaag 499021 aaatgtaaat aataaaaatg gattagaatg taggaataac aaaagaggtc gttaatgttc 499081 taaacataag ttggagaaga tttgcttttc atcataatat tccgaaatat cttttgggat 499141 gtatctaacc aaaacttttt atttgttttt cagtgattcc tttaattact tccagttcac 499201 taatcaaaaa ttcatatgca ttatccagca tttttttttc gcttgcatta agtgcttttt 499261 ctttcttcat acgcattaaa tcacgtacaa cttcagcacc ttcttgtatt tcacctgttt 499321 ttattttgtc cgtgtttatt ttgtaccttt gcttccatgg cagtaaccta tcggattctc 499381 catgctgaaa aatgtgcata atgtgtttta atgcaagtat atcggtaact ggtcgtatat 499441 tcgaactcaa tattttactc gttggaatca taactgtcat attactgatt gacattctta 499501 tgacataata ctgttgtttt tcctctaaga attctttttc ttctatggct tcaattatac 499561 ctgctccgtg cattggataa acaatgttat cgccaatttg aaacatatca tccacctcca 499621 tatatggtat ccttcttaag attaccatat atggaggtgt aatatcaaaa ttttaataat 499681 aacatgatcg aatttttgat gtcaataact tttttgaaaa aacagatcaa gcaaaaacaa 499741 tagggaacgt gtcggatttc caatcaggaa aaggtcaatt gatccgtgtg agcagttttt 499801 cattggctca atgacattac agaaatgatt tgagtagata agaaagaacg atattcgtga 499861 aatgtcagct aaaaatattt aaagcacatg attaagttct aatttcttta ccgatttgat 499921 atggataacg gccgacttac ttaatgatgc attttcactt atcttgcaag cagaaaaagg 499981 tttgttgata aacatttagc caccaaattg gcattattat cagggaaatt gacaaccttc 500041 aaatgggtat tgaggcgaga agaaaaataa agaaaggaga gattataaat gaagaccaga 500101 acataaagaa gtaaagggga aagaacaagg ttaattgaaa agcaaactat ataaaatagt 500161 ttgctttttt ttgttatgac ttcacttctt tttctttctc tttaatgact aataaaacac 500221 cgctcagaat taaaaacgaa cctatccaaa atgtcccgcc tatttgttct ccaagcagaa 500281 tccatccgag taaggttcca accagaggct gaaaaaagaa aaagaggcct ccacttgagg 500341 catttaataa ttgtaagccg tggttccaca ataaaaatgc acaagctgtt gaaacaattc 500401 ccaaatacaa aaggccacct agaattttag ggtcaagcag tagtggcgta aaaatcgtgc 500461 taggggagta ccattaacag ggactccatt tattaataga ataaacttta tgaattcatt 500521 tttttgtatg ataatggcgt catattcatc gcttgttgaa atttacttat gaaataactg 500581 gtactgttaa atccaacttg ataagacact tctgtcacat tggattcagg gtgttgcagt 500641 aataataagc ttttttgaat tctataatcc attacataac gtaatggcgt cttattcagc 500701 attcgtttaa aataacggca gcattcagaa cggctcagtt ggccagcttt tgcaatgtcc 500761 tctaatgtga ttttttcaac ataatggaga tggatccagt ttaacatttg tttcattcga 500821 tgacttttta tcatttcaga ttgatcgtac tctaattgaa aaccattaac gaccaggttt 500881 ttccacatta acgttaattg catcgtaatg tcaatctcat agagcgatgt cttttgttga 500941 atcaattgat ttattttttt aacagcatct agaatatttt ttgcccactg ttgatttcca 501001 gccaaaaata aatagggcaa attggttgaa aacatatagg gctgaacata gcttgaatac 501061 agttcctgag ataaaacgaa atggggtgac acattcaagc aaatatacgt acaatccgag 501121 ccttcctttt cttcggccat gtgcaggtag ccgctattga taaataatcc atccccttcg 501181 tgaacctcta ttttttcttc atttatttga aagagagcta tcccttttag tatcaaaaca 501241 aattggattt catcatgcca atgaagcgga atatagccat ttatattttg attgatcgtt 501301 gtcttgtagc aggcaactgg caattctacc gttcggtgct ctgttaattc ttttaaattt 501361 tgatcgatca caaaattctt cattctgact tcacacctca atatatttat attttttcat 501421 tcaatttgag tattttttat catgttttgc atttattata acactattat tatatttatt 501481 agtgaggagt catgtatgaa tacttccaat agaagaatgg gattgttcta tgttatcaca 501541 ggggcgacat gttgggggat tggaggcaca gtagccaaaa aactttttca agaatatcaa 501601 attgatgtca attggcttgt aacgacacgc ttgcttacgg ctggaatgtt acttttaatg 501661 ctgcaactgt tcagaaagga tcgttcccag gttattgagg tgtggaaaca caaagcgtcg 501721 gctggccagc ttctaatttt tggcctattg ggaatgctag ctgtgcagta cacatatatg 501781 gcatccattc aacatgggaa tgctgccgtt gctacgttat tgcaatattt atccccagta 501841 atcgtcatta tctacacgct gttgcgaaaa caaacggttc ttaccaaaca agatatcata 501901 actgttgtac ttgctttagt gggttgcttt tttttgttaa caaatggttc aatgtctcaa 501961 ctttcagtgc cggcagctgc agtagtatgg ggagttttat caggattcgc ggcagctttt 502021 tatactttgt atgccgttgg tttattaaat aaatttgatt ctcttgtcgt tgtaggttgg 502081 gctatgatta ttggcggttt tgcattgggt tttatccatc cgccatggca actggatttt 502141 caacgattaa ctgctgaggc gtatgcatat atcttattcg tgatattatt tggaacaatg 502201 attgcgttct ggttcttcat aaaaagcttg gaaagcctct ctccaaaaga aacaagccta 502261 ctaggcagtc tagagcctct atcagctgtt gtaacaactg tcgtttggtt aaaagcgcca 502321 tttggttctt ttcaatggat tggtgctatt tgtattatag ggataacttt aatattggct 502381 ttacataaag agccttctat ggagagtgaa aaatcgatat taaagattag gaatcatgca 502441 aatcgggata tataggggct ttttttgctt acatgaccgg tccggcaatg aaaaacactg 502501 gtggagtttg agccctctcg gcagtatcaa aaataccaag ggttttgacg ccctaggtat 502561 tttttcttca agaaccttca atttttcttc tctgattgaa aaacgtatta cttttttgtg 502621 attggtatcc aaatttcact tttaaaagat ggtgatgtta catccttatg ctcgttccac 502681 aatatttctg gaccttctat ttgttcgtaa tttgacgatg gaaaccattc ggaataaatg 502741 cgtccccata cttcttgcag tgtatccgga aatggcccga ttgattcgaa tacagcccat 502801 gttgaggcag gaacttcaag ccgtgagaag ttatctggac accgtttcgt tgtggctgcg 502861 ccaatatagt gatcgagctc tccgttttcc tctgtccgac cttcagaaaa attcgtggat 502921 gcactaatga ggcctgatgg tgctacatta gatagctctt ttagtttatt tattgctttt 502981 tcatctaaac tttcccacat agatgcaatt tccggattaa ttcctttgaa aataatagga 503041 actctttttt taatgccaac gatgcgaaat gcctcttttt cttcaatacg gtagttcatt 503101 tcatttcctc ctttaattgt tagctggaag gtcattcgtg gataagcttt aagggaatgg 503161 ccattaaatc tggcttttga tgggtttatg ccatgtaaat tttggaatgc ccgtgcaaaa 503221 gaatctggtg agttataacc gtactttatt gcaatatcaa tcacttttac attgctgtct 503281 ttcagttcaa aagctgcaag agtaagacgt ctgcgacgaa tatattccga taatgaaata 503341 cctgcaagga aggaaaacat ccttttaaaa tgatattcag agcagaaagc aagctttgct 503401 gcctcttgaa aatcaatatc attagtgagg ttttcttcaa tatactttaa cgccctattc 503461 atacttttaa gcaaatccat ttatttggcc tcctttaacc aaagaataac aggagtgaaa 503521 tgtatttatc cgacattctg tgcacagttt tgcaggatga cttatatgaa ataaagtaag 503581 tgattcactt gtatttgtac aggttttatt gaagcatgct gttcataaaa aggcatcaat 503641 aaaagaaagt tataattgtc ttataaacgg cacattcata taattgagtg aaaaaggatg 503701 cgtatcatgc ctatcaattc ttttgaaaat tatccgatga gctggaagcc atcgattgat 503761 aaagctgaaa agcctattta taaagcactt gcagggcaat tggaacagga tattttaaac 503821 ggagttttat tacctggaac aaaacttcct ccacagcgag aattggccga ttatctagat 503881 ttaaatgtga gtacgatttc aaaagcattt aaagtgtgtg agttaaaagg gctgctgagt 503941 gcgactgtag ggagcggcac atttgtatcg tatgatgcgt tgtcgaatgc gtatttactt 504001 gaggatacta agccgacaca tttaattgaa atgggagcaa tacttccaga tcacgcttca 504061 tatgagccct tgttatacca actgaaaaac atggttcatg aggaggatta tgaaaaatgg 504121 tttagctatg gccgggcagg tgaaagcctt tggcaaaaag atgcagctgt aaagctcatc 504181 caaagaggcg gatttgaaac atccgttgat cacattttat ttgcaaatgg agggcaaaat 504241 gcgattgcag cgacattggc gagtctttgt aagcctggag atcgcatcgg agttgaccat 504301 catacgtacc ctggattaaa aactgttgca tcattgctta gtgtgcaaat cgtaccgata 504361 aaatcagaaa acgatgaaat gagtccggag tcacttgaat atgcgtgtaa aaacgaaaat 504421 attaaaggtt tgtatttaat cccggattat cataatccga cgacttcctt tatgtctgtt 504481 gagaatcgaa gaatggttgc agacattgta aagaaatata atctgtttgt tattgaggat 504541 gcatcgtacc atcttctcaa caaaaatccg cttccggcac tcgcctcatt cgcaccgcaa 504601 caggttattc atattgcaag tttatcaaaa tcgttagcgc caggcctgcg tttggcttat 504661 gtagcagtgc cgagacaata taaggagcca atatcaaagg cgctttataa tttaaatata 504721 actgtttccc cgctattagc tgaacttact gctcgcacga ttgtatcaaa tcaatttgaa 504781 gtcttaattg agagtcatcg tgaacaaacc attcgcagaa atcaactcgt aaaccgatat 504841 gttgcgggat atacatgttt aggtgttgaa acaggcattt ttcgttggtt gttgttaccg 504901 ggtaaaatgt ctggtgccga atttgaagaa ttggctgctc gacttggcgt gcaagtgtat 504961 gcggctgaac gctttgtagt gggaaatagt tgtcctgaaa gggctgtaag ggtttctgtc 505021 tgtgcaccaa aaacacttga agagcttgaa caaggattaa tgatcctgag acgtttgcta 505081 gacgatctta cctaatattg tttgccatac aattatgaca ttgtatggct tttttgtgcg 505141 tgttatgatg atccacatct agagggaggt ttatacaaaa ttggctttta gaaaggaagg 505201 tcagatgatg ttagacaagg acagcgtaaa agcaatagat gttcaaactg cttcattaca 505261 gagctacatc agttcaccag aaaaacaaaa atcgttatac aagcgtacac tattcgttgt 505321 gagtatctca caaatttttg gcggtgcggg gctggcggca ggagtgactg tcggtgcgct 505381 tattgcacag caaatgcttg gcactgatgc gtttgctggt ttgccttctg ctttatttac 505441 tttagggtca gcaggatctg cattaattgt tggaagactt tctcaacgtt atggccgtcg 505501 aacaggtctt tcagctggct ttatgattgg cggacttgga gcaataggcg ttattatggc 505561 agcaatcata aatagtattt tcttgttatt tatttcgttg cttatttacg gtgcaggtac 505621 agccactaat ttacaggccc gttatgcagg tacagactta gcaaatcata agcagcgagc 505681 gactgctgtt agtataacca tggtttttac tacatttggc gcagtggcag gtccaagctt 505741 agtgaatgtg atgggggatt tcgctctttc tattggtgtt ccatcacttg ctggcccttt 505801 cattttagcc gcagcagcat atatgttagc aggtgtggtc cttttcatta tgcttcgtcc 505861 agatccatta gttatagcaa gaacaataga agcggcaaat gaagagcctg gtgataaagg 505921 acatttggcg gcaactgagc atacagaaaa caaaaaaggg ataatcgttg gggcaacggt 505981 tatggttctt acccaaatag taatggtagc tattatgaca atgacaccgg ttcatatgag 506041 acatcatggg catgacttgg gtgcagtcgg tcttgttatt ggttttcata taggtgctat 506101 gtatctccct tcacttgtta caggtgttct tgtagatagg ttgggacgta ccgcaatggc 506161 tatttcctct ggaacaacgt tgcttttggc aggtgtaata gcagcatttg ctccgggaga 506221 atctatgatt cttctcgtca ttgctctttc tttactggga ttagggtgga attttggttt 506281 gataagcggg actgccctta ttgtagattc aactgatact gccacacgag ctaaaacgca 506341 ggggacagtg gatgttctga ttgcgttgtc aggagctgct ggcggagcat tatctggaat 506401 gattgtggca ggttcaagtt acctcgcatt atcacttatt ggagggattt tgtccttatt 506461 actcattccg gtggtggtat ggtctagggg ccgctaaagg gtaggattgt ttaatttaca 506521 ttaatttgtt atattgttag ataaagtata ttgcagcatc taatattcta acgaactata 506581 gttgctccat taaatctatt ataaagattt gaccaggatt ccttatagct gtgtcactca 506641 ctgcatattc tttaattgaa tcacataaaa tggttatcgg atttgaaaaa ggcaggatta 506701 ctcgctttag gtaaaggagt cataacgttg ttaaaaaggt tttctcttgt tattgttaca 506761 ctaatgatgt ctatcgttgt tgttttagcg gctgctaaag agtcgcctgg agatcatgtc 506821 atctcatttg atgaacctat tatcttgatg atctcaattg gaatcgttgt atttttattg 506881 atccctccat tagtcatgtc cttttttggc aatttggttg taagaataat atctggtgta 506941 taccaatgtt ttatcgtttt cacttttctg gggctcattc caattggatt tcttattccc 507001 aatggctttt tgacaattct agtttctatt gcaggaactt tagtcagtat agctagtgtt 507061 gccgtaacct tatgcattgg caagaataaa aaagatatat aatcatcgaa ttgttatttt 507121 ttcagattgt cagtgaaata attatacaaa aagagaaggc ttgtgggcct tctttttttg 507181 ttgttgcatc atccccactt tgagcttaat ctattgaata ataagagaag gaacctatag 507241 aagaataaaa taaataccga gatgtcaaaa ataaaactgg acttcattat tgtgaattca 507301 cgtaaatgta aaaagattgg aaagagggga attccttcat gacaaatagc agaacaaatc 507361 cgaaggttga tgaattttta agtaaagcga aaaagtggaa ggaagaattt gagaagttga 507421 gaaccatcat tcttgactgt gagctgactg aagattttaa gtggatgcat ccttgttaca 507481 catatcataa taaaaatatt gttttaatac atgggtttaa agaatattgc gcgcttctgt 507541 tccacaaagg cgtcttatta caggatacag atggaattct cattcaacaa acggagaatg 507601 tacaggcggc gcgccagatt cggtttacaa atgttcagga aataaatgag ctagaaaaca 507661 ttttgaaagc ctatattcac gaagccattg aagttgaaaa agccggtttg aaagtggatg 507721 ttaacaaaaa tattgaattg aacattcctg aagaacttca aaataaattc gatgaaatcc 507781 ctgcattgaa aattgctttt gaagctttga ccccgggacg gcaaagagcg tacactcttt 507841 atttttctca agccaaacaa tccaaaaccc gagaatcgag agtcgaaaaa tatgtgcaaa 507901 aaattctcga tggaaaggga ttaaaggatt aggcacgcca aggttcaggc taaaggaata 507961 gcatcatagc gtaataagat catttctata gaagaaaaac aagcatagta agatgcttgt 508021 tttttcttag gacaacattc acttactgct gaaatgcttc taacattgta tgccactaga 508081 cagcgttata aaatattaat gcaacaccta gaaatctatc caatgaaata gctcaatggt 508141 atggctcatt acatttagaa tgcctaggag aactaataga accggaagat ttttagcaag 508201 ttactacact ccaaactttg tttttgtatt aatatacctt attaaccatt gtttttagtc 508261 aggtgcagac aaacgaatac tgattaatga atcatcatga tatcaatgag ccgcttgatt 508321 ttttcatcgt cgcctgtatc aacgtacact gtttttctgt tttttatgat actctcagtc 508381 acttcccgca tgacgccttt ttctatatca tcagcggaat cccagcgtaa aggcacatta 508441 tatacatgaa ttgtgccatc cccattgcca tgataagtga ctgatccatc cactaaacga 508501 gaacctgcca actgggtcac attttctgga tagctggcac ttgtatcatc attaggatta 508561 attggctcgc cagccgcaat atgtcgaaca tttaattcat ctatctcttg attaggtcca 508621 agttgaagcc aaactctggc atattcaatt ttttccgaag agtatgctgc caatacattg 508681 tcttctttgc ttttctcttc tgctgaagag gtatcatttg cagcttttgt tgcggattct 508741 tctgattctg ttattggctc cgcttcatcc ttgcgtattt tggtgctctc ttcaggctca 508801 gtgtgttttt cgtcagtttg cacagcagaa gcttgatttg aaggttgttg tgcttctcca 508861 tccttactgt ccgtacatcc agcaagcaaa atcataagca gcagggcagt attgcaataa 508921 catatctttc tgcgtttctt cattttttca ttcctctcta ttaattcagg tcagcttcat 508981 atataagttt atgtatctaa atattaccat ggaatagata ggatgatatt gaaaactgtt 509041 taagaagagg aaacgatctt gaatagcatc gcgaaaacct aagaatctta agaagttttg 509101 cccctttttc ttcaggtatt gaatgtaaag tgggatataa atgcaaacaa aaacgaaatg 509161 ccttatccac ctcgtgtcat ggcagaaaaa gtgggggatt tattagagcg gatttgataa 509221 tggcggcagg taaatgggtg ttgacttata tgtctaagcg ggagactcaa gtctgctcga 509281 tcgcatacaa aataccaagg gccagcaacc cttggtattt ttataccttc atgcattttt 509341 gaagtttatg cttaaaggtc tgccttactt tgcaaatcgc cgagctgctg caacgcacat 509401 gataacggcg atattcactg ctacgagtgc ccagcccact ttctcgtgca gaatcactga 509461 ggcaagcagc agtccaaaaa aaggctggag aagctggagc tgcccaaccg ctgcaattcc 509521 cccttgggca agacctcgat accagaacac gaagccaatc agcatgctga ataaggatac 509581 atatgcaaga ctgagcagtg cgggaacgcc gatcgccgac catgagtccg gcgtaaaaaa 509641 gaacgacaat ggcagcataa gaggaagcga cagaacgagt gcccatgaga tcacctgcca 509701 attccccaga cgccgtgaaa gtttggcccc ttctgcataa ccaagaccgc atacgacaat 509761 agaagccagc atgtacgcgt cgccaagcgg ggatgaacct cccccctgaa tgagggcgaa 509821 acctgctact aacaagctgc cggcagctga gaaaatccag aagacggggc gagggcgttc 509881 acccccgcgc agtacgccga agactgccgt tgcgagtgga agaagtccaa tgaagacaat 509941 ggcgtgtgcg gatgtgacat gctgaagcgc taaagctgtc agcaacggga aaccaatcac 510001 tacgccgaac gctaccacta acaatgaaat gagatctctt ttggcaggat gctgctgccg 510061 gaagatgaga aggagacctc ccgccagtac accagctatc gcagcacggc aaactgtgag 510121 aaataacgga tcgaagtctg acacagccaa acgggtcgca ggcagcgagc cgctgaaaat 510181 gagtacgcct ataaaaccat ttatccagcc atttgttgtt ttgttcatta taatcactcc 510241 acatatcttt cttgttcatt gtctgtattt tcttaacaaa accagcagct aaggattaca 510301 atgactataa actggaattg gccttttata aacagccagt tttcataaaa aaatgcatac 510361 cagttaggag aacaacgcgc aaatggatat cacgcctttt ttgaatagaa ctctggatat 510421 tccgctttat cagcagcttt atcggtattt taaagaaaat atgcatcggg gccgtattca 510481 aaaaggaatg aagcttcctt caaaaagact cctggcgaat cagctttcca tcagccaaac 510541 gactgtagaa cgtgcctatg aacagctcgc tgctgaaggt tatattgtga gcaagccaag 510601 aagcgggtgg tttgctgatt atcatgattc tgattttgct tatgatagaa tgccaagcac 510661 aacacccatt caacaagaag cagaagaaaa taaacaatgg attgattttc attatgggaa 510721 tgtagattct tcttacttcc ctttttccgc atggcgaaaa agcatggtca atagcttaga 510781 ccaatatgga cacgagcttt atcggccggg acatgtttta ggagagtttg agctgagaac 510841 actcattgca gagtacctgt atcaatctcg gggggttcat tgcggccctg aacaagtgat 510901 tataggtgcc gggaacccta ttctgctgca aatcttgtgc caagtttttg agccgaatat 510961 ttctataggg tatgaggatc ctggttatcc aagagcacgc aagatttttg aagccaaccg 511021 catgaatatt gttcctatac cagtcgatga tgagggaatc tgtatacaga agatcaaaga 511081 acagcagcca aaccttgtat atgtcacacc ttcccatcaa tttacgctgg gaaccataat 511141 gacaataaac agaagaattc agctgctcaa atgggcggcc gaaaatcaat cctttatcat 511201 agaggatgat tatgacgggg aatttaggta cacaggacag ccggttcctt ctctgcaagg 511261 gcttgatcag cataaccgtg tcatttatat gggcactttt tctaagtctc ttttgccctc 511321 gctgcgtatc agctatatga ttcttccttc gcctctttta aaaaagggtc atgaaatcac 511381 gtccttatat aagcagacag tgtcctgcca cagtcagcta accctagctg aatttataaa 511441 aaatggagag tggcaaaaac acatcaacag aatgagaaaa ctttaccgca aaaaaagagc 511501 cattgtatta gaggcagtgc aaagggaatt aggagagcat gtcagaatcc gcggagaaaa 511561 ctctgggctt cgtatcttac ttgacgttta tttgccattt ggtgaaaaag agttaattga 511621 gaaggcgaaa aaacatggag taaaaattta tcctgtttct ctttcttatc aacatcatcc 511681 tcctacaaaa acggtctcgc tcgggtttgc aggggtttct gaatccgaca taagagaagg 511741 cataaaaaaa ctgaaggctg cctggaagat atgagggagc tttcagttta gcaaaacggc 511801 caagtgacga ctaagtgttg agagctgttc aatatttttt aagtatatga tgagtgcctg 511861 cagtccaggc cacgatacgt ctgtttagcg aaaaacagaa ttttttattt gctcctcaca 511921 gtgctaaaat aaacaaaata gacaattgaa aaaatagagg tgtaagaatg aagttagatg 511981 agtttacaat tggccaggtc ttcaaaacga aatcattaaa agtatcaaaa gatgatatta 512041 tgcggtttgc gggtgaattt gaccctcagt atatgcatgt agatgaagaa aaagcgagta 512101 aaggcagatt taatggaatt atcgcttccg gcatacaaac actggccata tcttttaaac 512161 tttggattga agaaggtttc tatggagacg atattatagc cggaacagag atgaatcata 512221 tgacattcat aaaacccgta tatccggatg atgaattgtt tacaattgtt gaggttcttg 512281 ataagcagcc aaagagaaat gaattgggaa tactcacagt attgctatct acttataatc 512341 aaaaagaagt aaaagtgttt gaaggtgagt tatctgtatt gatcaaacga taactcagaa 512401 agcccgcttt tcgcgggctc gattgaagca gatgggtgaa agatgttagc gggtttcctt 512461 tgaaaaataa gaggttaaaa catcataaac aataggcaaa gaagtaaatc cctcatcttc 512521 tagaaaatga cctccgtgct gaacttcata taacgcagca tcaatttgtt gtgccagatc 512581 cttgctgaat gaaaaaggca caatttggtc gtccttagaa gcaatgacag cacggtgctt 512641 cgcggactcg atgatttttt gatgatcaaa cgatccctgt gtaaattcat ctaacatctg 512701 taaagtgggc aatgatttgg caaagccgga aacaagtatg attccgccaa gctgttttcg 512761 taattgaaga tgttccaaaa atctcaaaat ggcggggcaa cctaagctgt gcgcaaccaa 512821 atacgtattt tcatgtaaag tgtgctgata taaagagagt gtatccagcc aatcctcaag 512881 tcttggctgg agcggattag gcatgtttaa aatgtctgct tggaccccat ctgcgagcag 512941 acgttttttc agccaaggga accaatgatt tgttgaggag gctctgtagc catgaatgat 513001 atagacttgt tttgtcatta tttcctccta agaaatattt tcattcagta taaaattcct 513061 ctcattggga aacaagtacg cacttttttg taagtagctt tacatatgag gccctccttg 513121 tgccattccc cacttacaca tctcatctat gaggggatac aaagatcgcc ctctgtcaga 513181 taacgaatac tctactttca gtggggtgtg agaaacctca gaccgatgaa taaggccgtc 513241 agtttgcaat tccttaagct gtgcgcttaa cattttatgg gtgatgaagg gcatagccct 513301 tttcagctcg ccgtatctca tcgttttttc acaccctaac tcatagagaa ttctcatttt 513361 ccatttgccc cctataagag ataaggtgta ttcaaatggg gcttgtttac tgcggcacag 513421 gctattcatt gtaatcaaac ctcctttttt aagtatcata tcagaataaa ttaggatttt 513481 cggtgttgaa gtttgagggc gattcacgat ctgaagtgaa aggggccgct tgctcaacag 513541 gcggcacggt acatgaatgt tctaagtcaa agagggttac cttactgtta gttactttat 513601 ttaaaaaaac gcatgttttt agctgaaaat atctattatg gtatatttaa atataaagaa 513661 atatttgaga aatgaggaat ggtatgaata cacccaaaaa acataagaaa tttaaagcga 513721 aaatgattct ccaaatcatc atggttatca ttggaggaat catagcggca tatggactag 513781 aaacagtgct cattccaaac agtgtatctg atggaggggt gacgggtctt agcatcgttg 513841 gttcacagct attcaacttg ccgctgggga ttttgattgc tgtgatcaac attccatttg 513901 tctggttagg atataagcaa attgggaaaa gctttgcatt attatcaatt atcggaatcg 513961 tatcgcttgc cgcggggaca agctttttcc accacacacc cgctatcata gaaggagata 514021 ccctgttaat taccgttgtc ggcgggatta tccttggatt cggaatgggg ctggcgctgc 514081 gtaatggcgg cgcattagat ggaattgaca tgcttgctgt gctgctatcc cgaaaactgc 514141 cattcggaac gagcgatctc attctattct taaacctatt tgtgtttatt tttgtttcca 514201 cagtatttgg cttacaaggg gcattgcttt cagtcattgc ttactacatt gcatccaaag 514261 tgattcatgt tgtggaggaa ggcttaagcg gctctaaaac ctttcaaatt attacaaccc 514321 aacctgaatt aatggtagag acaatacgtg atcaattagg ccgaagcgcc acatataaag 514381 aagcttacgg gggtttttcc cacgagaaat ttaaagaaat cacatgtgtc atcaaccgtt 514441 tagaagaaac caaactaaag gaaattatta atgatattga taaaactgcc tttgttaccg 514501 tgtatgatgt agctgaagtg aagggcagca attttagaaa tcttaatcat cactaaaaaa 514561 tagaatgacc tttttaaccg taactgacat gccgcgggta atttaatcaa aaacactttt 514621 ttgaggcttg tgggtgaata accggtgaag gtctgaatca cagaaatacc aagggcgtca 514681 aaacccttgg tattttttct ggttattaga ttttatcttc agctttacgt gctgcttcga 514741 gcttatcaat cctgtcttta tatttttctc cccagtcctt catgtgcagg ataacaggtt 514801 ctaatgttct tccaaactca gttaaagagt attcgacttt tggagggacc tgtttataaa 514861 cctcgcggtg aatcacgcca tcccgttcca attctcttaa ttgtagcgtg agcatacgct 514921 gggtaatttt tgggtatagt tttcgaaact cattaaacct ctttttaccg tcaatgagat 514981 gataaagaag aatgcctttc cacttacctc cgatgatatc taatgttgtc tccaccggac 515041 atccttcaaa gtcatcagaa gaataatcaa tgccgagttt acgatttctc aagctgttca 515101 ctcctaatag tatacttttt gatactatat acattcaatg tgcgtacttt ttatatttta 515161 atatacatca tataatgatg tcacatctaa ggaatgaaag gaatggatca tatgaaaaca 515221 ctcgtactcg ttgtacatcc gaatatagaa tcctctcgta tcaataaaaa gtggaaagaa 515281 gccgttttaa gtgaaccaga tgtaactgtc catgatcttt atgaaaaata tcgcgatcaa 515341 ccaattgatg tggaatttga acaacagcag ctcctggccc atgaccgtat cgtttttcag 515401 tttccattat actggtacag cagcccaccg cttttaaaac agtggtttga tgaagtgttt 515461 acgtttggct gggctcatgg tcccggcgga aataaattga aggggaaaga gtgggtaact 515521 gccatgtcca tcggttcacc tgaacactct tatcaagccg gcggatataa cttgttttcg 515581 ataagcgagc tgacaaaacc gttccaagca tctgcccatt tagtaggcat gacctatctg 515641 ccttcctttg ccgaatatcg cgccaataca atcagtgacc aagaaattgc cgaaagtgcg 515701 aatcggtatg taaagcatat tacaaatata gaattaaacc cgaaggttcg cctgcaaagg 515761 tatttgaaac agctggagag tgtcgattta acataaagat tgatttttga aaatcctgta 515821 ctcaccaagc aggatttttt cttgttcagc agagggattt taacatatag caaaaaaaga 515881 agaagccacc aaaaataagc tatttgcttg gtcctgactg cttatttttg gtgaaatact 515941 tatttctctg tgatgaaata aagcaaagcg atgaccggaa aagcgattcc aatccataat 516001 gctgtactcc atccgcctga ggcatatgcc catcctccaa ttgatgaccc tatcgcaccg 516061 cctagaaaga agatcgccat gaataatccg tttaatcgac tgcgaatttc aggcgccaac 516121 gaaaaaatag cacgttgact gagcacaagg tttgcagata cacccatatc taacagaata 516181 gcagcggcca ctagaactgt tataccgacg ggggagctgc tctgaatcat gagcggcagt 516241 aataaagaga caacgacaac accgagagcg attccagtgg caagcctggt taagcctcga 516301 tcagccaggc ggccgcctat tggtgcagtg actgcacccg caatgcccac caatgcgtag 516361 agtgctattg ccttctgaga aaaatgaaaa tcaggaccgg acaataataa aggaacagtt 516421 gtccagaaca agctgaaagc tccaaataca aacgcatgat agatggcacg gcggcgtaag 516481 actggagtcg tgcgcagcag cttccacatt gaaccgagta aggcagtata gtttgtattt 516541 gctgttggtt ttctggcagg aagcactttt gataatacga tggccaggat aacacttacc 516601 acggcggaca aagcgaatat tgcattccac ccccagatat cagcgactag actagatatc 516661 ggacgggaaa gcataatacc gagtaataag ccgctcatga cattgccaac aacccggccg 516721 cgtgcagcgt ctgatgcaag gtatgatgca aatggaacaa gcacttgggc tgcgattgat 516781 cccaatccga cgaaaaacgc agctgctaaa aacagtgttc catgcttcac aaatgctgtt 516841 agtgtcaaag ccgctgcgct tagaaggagc gatacaacaa taagtttttt gttttcgata 516901 atatctccta aagggacaag gaatagtaag ccggcaacgt atccgatttg ggtgagtgtg 516961 acaatcaatc cagcaccgct tggagaaagt ccaattgcct tactaattaa tccgaccaag 517021 ggttgtgcat agtaaagatt agcaacaatg ataccgcatg cagttgcgag aagaagggtt 517081 aaactgggtg aaatcctctg acctgcttgt ttgtttccat tagccatatg aatgaactcc 517141 tttttaagtg gttttttgag tgtaatcatg acttctcaca agtgatttta taaactgaac 517201 gttcagtttc gtcgattaat aaaaataata tactaaacgt tcagttttgt aaatggattt 517261 ctgttttctt tttttattca atttaagtat actgaacgta tagtttatat tgcgggaagg 517321 aatgatttat gtgcagagta aacgagggcg gccgcgtgat gaaggaacgc ataaggcgat 517381 tctctctgca gcctatgacc tattgctgga aaaaggcttc gatgcggtga cagtcgataa 517441 aattgccgag cgtgcgaaag tgagtaaagc aacgatttat aaatggtggt ctaacaaggc 517501 tgccgttatc atggacagct ttctttcgac cgcgacggac aggctgcctg tgcctgatac 517561 agggtcgtca gtacaagata tagtaaccca cgccacgaat ttagctaggt ttttgacaag 517621 ccgggaagga accgttatta aggaattaat aggtgcaggg cagttggatg aaaaattggc 517681 agaagaatat cgcacgcgat ttttccagcc tcgccgcctc caagcgaaag gccttctaga 517741 aaagggaatt cagaaaggtg aattgagaga gaatcttgat attgaagtaa gcatagatct 517801 catttacgga ccaattttct atcgtctgct tataacaggg gatgaggtga atgattccta 517861 tgtgcgtgat ttggtgatga atgcgtttaa gggagttcaa gctacctctg ctacagagag 517921 tatgtagctg ataagaactg caaaagctgc ggattatatg acaaattggt tccatcgtac 517981 agtgaaatat aagatttttg ttgctgagcg gaatcatcga gggaaaagtt ctcttatcgg 518041 atgtcgaaaa agaagtcatt caatcgtgaa tacataacat catattatta cattcctttt 518101 catcgattgg aacaagggtt ctatacttca atggaatacc gcaaagttgg agtatttaaa 518161 caacagggga aaatcgatgg ccattatgta ggtgtcatgg caatggaaaa aatacttgca 518221 atgtaaacag gcctctaaag agacctgttt tttaatatcc agatgattgt ctagtttcag 518281 cttgggctct atgaccactc ccataactga aatagtctaa tatttatacc agaagggatt 518341 gtttatataa ataaaagttt atataatgac gggggcgcta aggaaacgcg gggagcgact 518401 caggttttcg tttcaaagtt ttgatcctta agatatacgg agcgctacat atggaaacgt 518461 aaaggggaat gtataatcat ttggcgtgta tataacgatt tgcttatata ttgatttggg 518521 aaggaggagc tcatatgacg attgatgttg cggcgatgac tcgttgtttg aaaacactta 518581 gtgatcaaac taggcttatc atgatgagat tatttcttga acaagaatat tgtgtctgtc 518641 aattggttga tatgttcgaa atgagccagc ccgccataag ccagcatttg cggaaattaa 518701 aaaacgcagg ttttgtgaat gaggacagaa gaggccaatg gcgttattat tcaataaatg 518761 gttcctgtcc tgagtttgat acattgcaat tgatcttaca tcaaattgat caagaggatg 518821 aattgttaaa ccatatcaaa caaaagaaaa ctcaagcgtg ttgccagtaa ggaggcatta 518881 gattgacatc aatgattttg gcagtattca tctttttatt aactctagta ttggtcatat 518941 ggcagccgaa aaatttatct atagggtggt cagcctgtgg aggcgcagtt ttagctctaa 519001 tagcaggtgt tgtcaatttt catgatgtgt taactgtgac agggattgtt tggaatgcga 519061 ccttggcttt tgtggccatc atactgatat cgttaattct tgataatatc ggtttctttg 519121 aatgggcagc gcttcatatg gctaaggctg caaaaggata cggtgtgcgg atgttcgttt 519181 atgtatctct attaggagct atcgtcgccg cgttatttgc aaatgacggt gcagctctta 519241 tattgacacc aatcgtatta gcgatggtca gagcattaca ttttaatgaa aaattagttt 519301 ttccttttat cattgccagc ggatttattg cggataccac ttcgcttcct tttgtagtaa 519361 gcaatttggt caacattgtt tcagcggact attttcatat tacgtttatt gattatgcat 519421 ccagaatggt tgtcccgtac ctgttttcgc tgctggcgag catcattgta ctttaccttt 519481 tctttagaaa aagcatacca aaacgctatg atctgactga ggttaaaaaa cctgttgaag 519541 caattaaaga tcaaaacatg ttcagactgt catggtatat cttagggctg ctgttaattg 519601 gatattttgc aagtgaattt ttttctatcc ctgtatcagt ggtagcgggc agcattgcaa 519661 tcattttctt aatcgctgcg caaaagagtc cggccgtcca tacaaagaaa gtggtgaaag 519721 aggcgccatg ggctatcgta ttcttttcaa ttggcatgta cgttgttgtg tatggtgtcc 519781 gaaatgccgg attaacggat gtcctttcag atgtgattca agccgcagct gatcaaggat 519841 tgtttgctgg gacaattgga atgggcttta ttgcggcgat tctttcttcc attatgaata 519901 acttgccgac tgttatgatt gacgcattgg ccattgccgg tacagataca catgggatga 519961 tgagagaagc gcttatttat gcaaatgtga tcggttcaga tttagggcct aaaataacac 520021 cgattggttc cttagcgaca ttattatggc ttcatgttct ttcgcacaaa ggtatgaaga 520081 tttcctgggg cacgtatttt aaaacaggaa ttatcctcac gatacccact ttattgatca 520141 cacttgtcgg cctgtatatt tggctgctga taatccattc ttgtttctaa aaggacaagg 520201 tcactatatc aaggaaaaca atgcactggt aactcttgcc gcagccaaat ggctgaaggg 520261 tgggggagaa aataccttgg ggctaagtgg aatgtgtaca gcgcaggaat cgaagctcaa 520321 ggatgacatc gagtgctgtc aaagcaatga aagaagcagg gattgatatt tcaaatcaaa 520381 catcggagaa atttgatgat ccggcaaaag cacacggaac agaagaagtg tttccaaagg 520441 gtccgtgatg aaattggtga ccgtttaaaa cagtttgctg taactgggga ataaagaatc 520501 gatatattca gcgttttctt gggttatata atacaatgtg ttgttcaaca ggtgtctgcg 520561 agctgagtgc agacacctgt ttttgttttt atttgtctga gattcgtaac agggaagtta 520621 tttagctggt gacagaggaa aattgatttg tgaacagaat catgaaggag acggtgtttt 520681 aaaggagttg tctgttttgc aggaattaac aaaaaaaaaa tacagtagct taaaaacaat 520741 gtttgatgac aaatattgtc ccacatttgt ctattcaata ttagaccaaa ccattccggg 520801 agctgtttat gcagatgatc aaacctttcc taaatcgttt tttataggaa ctgaatcagg 520861 catttatttt attgcgggag accaagggaa tcgggatttt catgatttca ttgcaggata 520921 ttatgaagaa caagtgaaat catcaaaacg atttaccttg ttttcttcca gtgatacatg 520981 ggatagcgta ctgaaaccca tactgaaaga tgacttaaac caaatgagaa gagctgcatt 521041 ttcttatcaa ccaaaatctt tcaaaaagac tttgcaactg ccaaaggggc ttgtattgaa 521101 aagaattgac gaagacatca tttcacatag cacagcgttt aacagcgcgt attatgagga 521161 gtattggaat tctgtctcac agtttgcttc aaaaggtttt ggatttgccg tattacatgg 521221 caatcacgta gtaagtgagt gtacctctat atttttaggg cataatcgag cggaaatgga 521281 tatctataca cttgaagaat atagaggact ggggttagct tattgcgtag caaataggtt 521341 tatagcgttt tgtatggaaa atgggattgt tcctagctgg gattgtgata tttgcaacaa 521401 ttcgtccatt gcattagcag ctaaactagg gtttaagacg gtaacggaat acactattta 521461 ctactctggc taaccttaat gaaagaacct taaaaggaga taccaaccga tgttggtatc 521521 ttttttgttt tagagttttt ttaccctttt agcagaaaaa tgggtgatga aaatcttatt 521581 cattttattt acttttaggt aggtaaaaca taccccgcca actgtaacca ctccgcctag 521641 cagagagagc agtgtgggta tctcgccgat ccagagccaa gatatgatca aggctaaagc 521701 cggtgtaaca taaagtgaaa gggttgcttc tgaagcaccg acgaatgaag tgacatatgc 521761 tagtgcgaag taaggaataa ccgtcggcaa taatcctaag taaacgatag acaaagttgc 521821 gcttattgaa gcgttcatca tctcttcgcc taagcctggc agaaacacaa gcataggtat 521881 tgttccgccc caaatggtga atgtaacgaa tggaataaaa ccatattttt ttatatagcg 521941 ggcttgaaaa acgaaataaa tactctccga aaatgctgcc agcaggatga ccaagatacc 522001 gctcattgaa tatgtaaagt ctcccgcccc aaatgcaatc aataatacac ccaataaact 522061 gatcatagag ccaagccatt tcgtaaatcc aaaatgctct ttataaaaca ggcgggatag 522121 catggctgag aagatcggtg ccgtagtaac gagtaagctt gcaactccgg cactaactgt 522181 tttttcaccg atgttcagca aaatgtgata gaatgcaaat cctaaaaacc ctaaaagaaa 522241 aatggcagga atgtctttca agtcgggtag gcgcatctga gtcaaaacag caaaaagcaa 522301 taatgccata gagccgatta acaaacgaaa taaagcaagg tgttctggcg tgtacccttc 522361 aagtcctgcg cgaattcccg gaaaagcaga tgcccataaa ccaatcatga gactatgaga 522421 tatcattatt tgaactgttt tctttcgcat tcctctcact cctctttaca aaaaccaacc 522481 agttatttaa tgtgtttcta tactaataaa gatttgatga tatggcttca accagttcaa 522541 tagattttga cccaaccaat ttattttaag gagaccgatt ctatgagctt tccagaagaa 522601 aaaaagatga aaaagctccc taagtacaga caaatcgttc attttattaa agagaaaata 522661 ggaaatggag agtggccgat tggaagcaag attccaagcc agcgcacgct tgcaaaagat 522721 tttcaggtaa atcggagcac agtgattaca gcgttagagg aattgatggc cgatgggcta 522781 atagaaggca caatggggaa aggcacagtt gttatcaaca acacatggac actgatggct 522841 aagaattctg ctcccgattg ggatcaatat gtcacctctg gcattcagat gccaagccga 522901 aaaatcgttc aagagataaa tcaatcagaa tcaaatacag accttataca gctcagtaaa 522961 ggtgaacttt cagctgagat ttttcctttg gctgttatga aagagatgat ggggaaggta 523021 tctcaacaca tggaggcatt cggatatgaa gaaccaaaag gttacttacc tttgagggag 523081 gcattaagca actatttaaa aaccattgga atcaacgtct catcttcttc cattctgatt 523141 gtctcaggag cgttgcaagc cttgcagctg atatcaatgg ggctgttaca aagaggatca 523201 accgtttatc ttgatcagcc ctcctacctt tattcattac acgtatttca atcagctggt 523261 atgaagctga ctggacttcc tatggataat gaaggacttt tgcctgaaaa tgttcattta 523321 acaagaggag agcggggaag ggctatctta tatacaaatc catgttttca caatccgact 523381 ggtattctta tgtctaaaaa gcgacgggaa gaaatcctag cagtaagtga gaatacacag 523441 cttcctatta ttgaagatga catttatcgt gagttatgga tcgatgaaat tccgccatat 523501 cctattaaaa caattgataa aaatggacac gtactgtaca taggaagttt atcgaaaaca 523561 ttaagcccag gtttgaggat tggatggatc gtcggaccgg aaccggtgat tgaacgttta 523621 tctgacatta aaatgcaaac agattacgga tccagttcgc tatcccagag agtagcggca 523681 gagtggttta cttccggcca ctaccagcag catgtagaaa aggttaggca gcaattaaag 523741 gtgagaagag aattggcctt gagtgcttta gaaactcatt tgaaagaagt ggcgacatgg 523801 aatatcccaa aaggagggtt ttttgtctgg ataaaaatat tgccttccat atcaatgaaa 523861 ttactttata ctaaagcctt atcaaaaggg attctgatca atctcggcag tatctatgct 523921 caggaaaaag ggaattatat tcgcttatca tatgcttatg catctcttga agaccttcaa 523981 aaggggattt atgagttggg tttaatgatt aaagaattgg caagcaggta acttttatat 524041 ccttaaatgg atgtttcact aaaaaagaga tcaagcctaa tgatcgcttg atctgataat 524101 aacaagggtt actagaatag accaaatcat ggttcggtct taaaataatc atgtctctga 524161 acgaaaagtc tttccgactt ctcttcctaa accaaagtag tgtctgaaat tatagataag 524221 cgggctccat ttggaagggt tgatatggtt ttcgtccaga atgatacttt cctcggcatg 524281 aaaatgtagt gcctgcgtct ctacaattgc gaatgacgat tcatattctg gaagccgaat 524341 gtgtttcact tcggcttcga tttggatagg gcattcttta attcgtgttg gtgatactgt 524401 ttttgattgt aaaggcgtta accctgctgc ctcgtatttt tcttttttat atgtaaatcc 524461 gatctgcttc tttaaaggcg gtatactctt ttttccgcta taagatgaaa ttctttcaac 524521 gttttcccat aaatccgggc caggcaagtt tatgacacac tctttgtgtc tttccaaatt 524581 gtcgatggct tttcctccca gtcctactcc aaggattata taatgtccaa gagcccaaga 524641 agaagacata ggactaatat tagtggttcc atcctcattc aatgtggtta gaagaaatgt 524701 cgaggtacca taatacatga tcttgggttt gatttcctta aatcgacgag tgtcttgttt 524761 tttgatgtcc aacgtttttt cctccttgtc acgcttacat ttatattgta aaggattaac 524821 atttcaacta tcatcgaaat atgaatgtaa ggaggaaaat catgaatcct aatattgcaa 524881 aaatctcttc gttgctatca gatccctcgc gttcttccat tcttctcagt ctgatggatg 524941 gaaggataca ccctgcggga gagcttgcat atctcgctaa cattaaacct caaactgcaa 525001 gttttcacct gaataaattg cttgaagcaa agctgattag cgtagagaag catgggagac 525061 atcggtatta cagattggct gactcagatg ctgcaaatgt gatcgaacaa ttgcttcata 525121 ttgcgcctaa agcaaaagtc aaatctttaa aagagtcaaa agagaaaaag gacttgcatt 525181 tcgcccggac ctgttatgat catttggcag gttatgtggg cgtgcaaatg gcacattcac 525241 tagttgagca ggggatgtta aaaaaagttg atttaaactt tgaggtgact tcagagggtg 525301 ctttattctt ttcgaagtta ggcatcaatg aagagcaaca acggaataag aggagagcct 525361 ttgcccgctg ctgtttggat tggagtgaac ggcagcatca tattgcagga gcattaggaa 525421 acgccctatt ggtgcgcatg ttagaagaag aatggatcgt tcgtatgcct aaaacgagag 525481 cgattaggat tacacaaagc gggaaaatcg cgtttgaaaa gcacctaaac gtgaagattt 525541 aggattttga agcggaaaca tcagatgatg aggcacgata tctaggagga gtaagatttg 525601 ttctaatctt actccttctt cttattttga agcagctcga ttccccattg caatagagat 525661 gcggttccaa ctgtttattt gattaatgat cagaacaagg tcaacatatt gttcctcatc 525721 ataatgttcc cgcacccgat gatatagctc atcaggaacc cttttagatg gaatgagcgt 525781 gatgtgttca gatagttcga gagccgcttt ctcttcaggt gagtaaaaat cacattcatt 525841 ccaagcatgt aaacagtaaa ttcgctgttc agtttctccc attttgcggg catcggacgt 525901 atgcatatct atgcagaagg cacagccgtt catttgagag actctgattt tgattagttc 525961 tctcgtcgtt cggttaattg aggattgttt cgtgtatttc tccatatcca tcatgatttt 526021 cataccttca ggtgcaatct catagtagga cactctttga ctcataaagc aagactcctt 526081 tccatagaat acctagattg tatcccggta ttgatcattt taccaatgtg cggtttgaat 526141 gacagctgtt tcagcgtctt ttggaaagaa gcttctttga ataaaaataa gggtagccag 526201 caatgatgag tggagctgct aatgcaagca gtatccatga gcctgattgg ctgtctctag 526261 tgactctaat gaatatataa gtaccgatca gaaaatataa taaagcacct agaaaccaat 526321 acatgttcat tcctcttttt ccttgctttt tggttgcgca tttttgtctg tcatatggct 526381 taatcgatca gggttctgat tttttaatac cttttcggtc cggattcctt ttctctttaa 526441 tgataaaatt gtgagatcaa tcgatttcaa tgatgatcat tccttcaatg aatagtaagt 526501 tccttatgat tttaaaggta aatttgaaaa gataaaacgt acatagaggc agaacgttca 526561 tgtacgtttg ggcaatgatc acttgttgga aactctaatg tttccctgca cctgatattg 526621 ttgtgttcct tctcttccta taaaatgatt ggatacatgt atgtttgcac gttgaaatat 526681 gggttcgatt ttcatgaatc tctattcggt gaaacaggta aaggaagtgg ataaggtttg 526741 cttataagga atccttttaa agataaatat tactcacatg ataggcgggc attaaacatg 526801 cttgcactca gagtgccggg cctggctttt attctcatga tctatatagc ctctatcgtg 526861 ctgcaatttg tttctggggg ctggtccatt ttattgcttt atgcgtttac catattaatc 526921 gccatttttg ctttgcttca ttggcactca tatcgctggg ttaagaaaag agtgattctg 526981 tatttcgcgg tacaaggttt gatcaccttt gcacttgcta atctcatgac tggcttcttt 527041 atacttgtga ttatcggcct ttatgcattt ttaattggac aaattatagg aatggcagac 527101 agaagaagga cttttctcat tctttatcta ttgctgctgc tggtcataaa ttcggcgtat 527161 caccttcata aaggtgaagt tttgcatttt attgttattg ctgcgccgat catgattgtc 527221 atcatcactt atgccgcaac attttttgcc caagtcgatg aaaaaataaa agctcaattg 527281 actcttgaaa ggctggagct ggctcatcag caggtagaac agctgacgct gcagaacgaa 527341 agacagcgga tggcccgaga cttacacgat acgcttgctc aaggtcttgt cagtttaaat 527401 atgcagctgg atgcgattca tgttcatctc gccaaaggca acacagagag agcgaaggaa 527461 atcatacaac aatcgatgaa aagagtgaaa agcacaatag ctgatgcacg ttcagctatt 527521 gacgatctcc gcagcaaatc agaagaaatc ggtgttttaa aagaaagaat tacctcgcta 527581 atggatcatt ttatagagtc gacaggcatg gcttgtttat tagattacag attgcatcag 527641 gtgctggatg tgcgtacagc tgaaaactgt tattacatca ttggagaatg catgacgaat 527701 gcggcaaagc atgctgaggc gaaaacaatc tggatatcca tttgggatga tgaaaaggga 527761 aggctccatt taacagttaa ggataacggc aagggatttg atgttgaaaa aggaaagaaa 527821 aagagaggac attatgggct tcttggcata caagaacgcg tcagggcaat aaatggccaa 527881 ttcaatatca agagtacaaa attgaaagga acacaaattg agatcactgt accaattcag 527941 ggagagatgc aagatgaata aggttttaat cgttgatgac catcttgtcg tgagggaagg 528001 tctgaagctt ttaattgaaa cgaatgatca atacaccatt ataggagagg cggaaaatgg 528061 aaaagtagca gtccgtcttg cagatgaatt agaaccggat atcattctga tggatttgta 528121 tatgccggag atgagcgggt tagaggccat taaacaaata aaagaaaaac acgatacccc 528181 catcattatt ttgactacat ataatgaaga tcacttaatg atcgaaggga ttgaattagg 528241 agcgaaagga tatctgttaa aagatacgag ttcagaaacc ctttttcaca caatggatgc 528301 agccatcaga ggaaatgtgc tattgcagcc tgatatcctt aaacgtctgc aagaaatcca 528361 atttgagcgg atgaaaaagc agcgcaatga gacgcagctg acagaaaagg aagtcattgt 528421 tctaaaagca attgctaaag gtcttaaaag caaagcgatt gcctttgatt tgggcgtctc 528481 tgagcgaaca gtaaagtcca gattaacgtc catttacaat aaattaggcg cgaattcaag 528541 aactgaggca gtaacgattg ccatgcaaaa aggtattctg acaatagaca actaaactgc 528601 atatttgaaa attgcccaaa cgtacatgcc cgaatgtacg tttttttcat ttcattgtca 528661 actacaatga gaaagaatgt gatcaagcaa tgtgttgaaa ggagattatc atgtcaaaaa 528721 tgttatatac attaggagga tgggttgctc gcaatcgcat aaaagcaata tgtgcgtgga 528781 tcgttgtgtt agttgctgcg ataggccttg cagtgacctt gaaaccaagt ttttctgagg 528841 atatgtccat acctgacaca ccttcggaaa aagcgatgga tgtgattcaa aaagaatttc 528901 ctcatggtcc tgataaaggg agcatacggg ttattttcgg tgctggtgat ggggagaaac 528961 ttactgggaa gccagcaaaa aaagcaatag aagatacgtt caaagaaatc agtaaagatg 529021 attctgttga ctcgattgca agtccttttg tgacagggac aatcgcgaaa gatggcacag 529081 ttgcctatgc tgatatccag tataaatcat cagcagatga tataaaggat tactctatca 529141 aacacttaaa agacagtttg aaaatggctg atgatgaagg attgcaaact gagctaagcg 529201 gagatgtacc gggagcggag atggagatag gcggtgtctc tgaaattgtc ggcattatct 529261 tggcttttgt cgttttagcc attacattcg gttctttatt aatagcaggt ttgccgattt 529321 taactgcact gattggttta ggtgtaagta ttggactggt tttgattggg acacaagtat 529381 ttgatattgc ttctgtcagt ctttcattag ccggaatgat tggccttgct gttggtattg 529441 attatgcttt atttattttt acgaaacacc gccagttttt aggcgaaggc atacaaaaga 529501 atgaatcaat tgcgagagcc gtgggaacag cgggaagtgc agtggttttt gccggactta 529561 ctgttatcgt tgcactttgc ggattaactg tcgttaacat tccttttatg tctgcgatgg 529621 ggctgacagc agggcttagt gtactgatgg ctgttttggc ttccatcaca cttgtgcctg 529681 cggtcttatc gattgcaggg aagcggatga ttccgaaatc aaacaagaaa atagaaaaac 529741 aaagcactga aacaaatgtc tggggacgct ttgtcaccaa aaatcctatc atgctaagtg 529801 tatgcagcat tctgattttg atcgtcatta gtatcccatc tatgcatttg gaactgggct 529861 tgcctgatgc tgggatgaaa gctaaggata atccggatcg ccgggcatat gacttgcttg 529921 ccgaaggctt tggagaagga tttaatggcc aattaacaat cgtagcggat gccacaaatg 529981 ctacagaaaa taaggcggag gctttcgcag atgcagtgaa agaaataaag ggcttagacc 530041 atgtagcaag tgtcactcct gcaatgccta ataaagaagg gaactttgcc atcattacgg 530101 tcgttcctga aacaggtcca aatgatgtca caacgaaaga tttggtacat gatgtacgca 530161 gtttatcaga taaaaacgga gtagatttgc ttgttactgg atcaactgca gtgaatattg 530221 acatttcaga tcgcctgaat gatgcgatac cggtgtttgc tgtacttatt gttggctttg 530281 cgtttgtatt gctgaccatc gttttccgtt cgctgcttgt gccgcttgtt gctgttgcag 530341 gtttcatgtt gacgatgaca gccactcttg gaatctgtgt atttgtcttg caagacggga 530401 atctcatcga ctttttcaaa atacctgaaa aagggccgat actcgcgttc ctgccgattt 530461 tatcgattgg gattctgttc gggttagcca tggattatca agtattcctt gtcagcagaa 530521 tgcgtgaaga atatgtaaaa acaaacaatc cagtacaagc cattcaggct ggattaaaac 530581 acagtggtcc tgttgttaca gcagccggct tgatcatgat cttcgttttt gcaggattta 530641 tctttgcagg cgaagcttct attaaagcca atgggctggc tctttccttt ggtgtactct 530701 ttgatgcctt tattgtaaga atgacactga ttccaagtgt catgaagctg atggggaatg 530761 cagcctggta tttgccgaaa tggttagaca agattattcc gaatgtggat atagaagggc 530821 atcaactgac aaaggaaata cagccggaaa tagatcatga acaaaagaaa caaatcagtg 530881 tgtaatagaa aaagcagatc ttttatgatc tgctcttttg cttatggtag tatttagaag 530941 atgaagtcgg cagttaaaag gagacgctta tggcgccatc actcattttc gatatggatg 531001 gaactttgtt tcatattggc agaagctgca tcatactagc aggcatccca ggagaagtga 531061 catgattttt tgactttgca ttcactactt gatgccaagg atcttgagaa tccttcttga 531121 aaataaagga ttttacaact gatcatataa gaaacctaaa gaaacaagca cacaaaacca 531181 gctgcgggtt ttgtccaaga aaaatagagt ccataagagg gactctattt tttgaagtgc 531241 ccggctagaa gcatattgca ggactttatg aatgcaaatc actatcttat aagcccttac 531301 cgtgaaatgc ctgtttctgc attgaaaaaa cgcattacac gttcatttac gtaagtgggt 531361 tgttccatcg ataaaacatg tccggcattt ttaatgactt ccgcctcaat atctggaacg 531421 aatgaagagg ctcggtgcag ggctgagtgg ggatcataga tgacttcatg ttcaccaagt 531481 aataatagga taggaactct tgctgaacgt aattcctcat cggtaaaaac atacggaaat 531541 ccgtcggcat taggatttgg atttcttgat ccatcctgcc acattacccc tgccttaaac 531601 tgcttcacaa aaatcgggtg cagcacattc tgatcattca tcatccaatt taagaatgtt 531661 tcaactccat ttgacgctgt aaggccaaga gcgtatttgt agaaatcgtg atgaaatggc 531721 aaaaacgttt ctgccggact cagtatagct gcgcttttta ctctctcagg catacgtaaa 531781 aggaaattca tcgtatggag accgccaagc gaaagtccga tcatgtggga cttttcgatc 531841 cccagattgt caaacacatc aagaagccaa ttggcgtaat ccgttcttgt accgcttaca 531901 ttctcaggaa tactcttgtt tttatcacct atgatatcaa ctgcataagt tctgtattta 531961 ctgctccaat cggcgatgtt gggataccac atcgtcgagc tgaataatgc tccgtggagt 532021 aatacaagcg gcggggcatc ctctgggccg cttgcaatca catgtgtttg accaaaacga 532081 gtagatatat agaatgattt acaacggacc ggccaaagac taaggctttc attataagtt 532141 tgataatagc ggataccgtt gtcacttaat tcgggaatac tagatgaatg gtttgacata 532201 caaatgcccc tcccaatttt gtttaaatga atgtgccgtt tcgtgatggg gaatctgatt 532261 ttgatataac agactttatt tacaatataa tacagttgtt attagacgtc aaatccaaga 532321 tgaaaaggaa aaaaacgatt gaaacagatt attgaaaatc aatataacag aatattaacc 532381 tcctttgtgg agccgcttca ttaaaaccgc aatccaaatg catgaatcac aaaaatcaca 532441 acaggaggga tcaggaggga aggcagcaga ttcagtgttt tgaacttctt gattccaaga 532501 atgcttagac ctgaactgag gatgagtatg cctcccacaa ttgtgatttc attaataagg 532561 tctgtattga ttgcgctctc cattacttgt gcaaataaat agatggagcc ctgccaggaa 532621 aataatacaa gtgcggcagc cgctattcca aaaccaaaag ttgaagcgag cacaatggag 532681 gtgatcccat ctaacatccc gtttgtcaga aggtatgtat aatctccatg caaagcggct 532741 tcaacagggc ctaatattga cagcgaacct atacaaaata ataagaccgc agttgataag 532801 ccctctgcta aattgctttt agaaaatttg ttcaccagct tgttgaatcg taattctaaa 532861 ttgatgatct ggcctagcaa acctccaatg gctaaactca cgatgaatag aatggggtat 532921 ttactatcag gcaaatgctg tgtaatggcg ttgatcccca gtgcgaccgc agcgaatccc 532981 attgcctgca tcaaaatatc ctggtattca tctttaatgc cttttttgaa tatccccccg 533041 attatgcttc ctgcaatgat catcactgtg ttaaaaatcg ttccaaacat aagctttctc 533101 ctccaaaaat cattcctgca taaaaaataa accctctagt tagtagagag tcaagggaga 533161 tcaaaacata ttcatgagat tatttgatgg gcagcaggat ttcagtcacg taattatcta 533221 ggttattcgt aatgccataa tcaatgagtg tgatttcgat tgagtcccct gctacctcat 533281 aatgatgttc tttcatatat gccagtaatt ttttgtagta tggttcggct tctggatgtg 533341 accctttaaa cctaatttgc agatattctc ttgaaggaaa gatgatttct gaagaagttt 533401 tttcattttc atcttcaaga atcataaata tactggaata tttgtcaaac tgttttgctt 533461 tcacatttgc tgcagaaatg gataaaccaa tcttgcctat gaatatatct tcgtttacat 533521 tcaggtgggt tctcaattca gctaacgaat gttcgatatc atggccgaga acatattcat 533581 gctgcaaata ggccacacgc attgcgggaa gtttgatttt tgaaatttga tgtaacggca 533641 tgttaacggc atcttctata tgtgtgatgc gtcgggagat ctttcgttca atgcgttcca 533701 attctttctt cttgcgatca atttcaacct gctggctttt tagtaaatga agaagagtgt 533761 ttgtattttg agagttataa aaatcaagaa gcttattgat tggcaggcct agggccctca 533821 aatacttgat ggtatccagc cgctcaaact gttgggtaga ataatatcta tagttcgttt 533881 gctcatcttt atattccggt ttcaaaaggc cgatttcatc ataataccga agagcagaga 533941 ttttcacatt gaataacttt gacacttctc caatcgaaaa aaattccttc attctaacaa 534001 cctttctgtc ctatgattga tatacacaca ttatatagta cggcgagtac taaaggtaaa 534061 gtttgcagca taaagaaaaa actccttcta aaaaggagct tttcattctt cgaaataagg 534121 atttacatgg atgagcactt cttctacatc tgaaaactgt cttttgattt catttcgaat 534181 ttcgcgggca atgtcgtgtc cctgcttaat tgtcaaatca tgatccaaag ataaacggac 534241 atcaagcaat ttatagtggc catgttctcg cgcgcggatt ctatcaattc gttttacctg 534301 atcacattga aaaataacag ctttatattc ctctatcagc tcgggatcaa cactcttttc 534361 catgagcaca tcaacagacg gcctgattaa ttccattgaa atcttaaaaa tgaggtaagc 534421 aacgattgca ctggcaatgg catcggcgta caacagatag gaccatccac ggctgtttcc 534481 gatgatagcc aacaggacgc cgataaaagc ggcaagagag gcaacgatat cgcctttatg 534541 atcgtacgca atcgctataa tcgctttgct gttccatttt ttcccttgct ttatagaata 534601 acgatataag atttccttag ccacgtacga aatcagagcc gcaaacaatg cgctgtattg 534661 gggaacgctt ggccctttaa caaaggacag aatcgcttct atgaggatat aaacggatac 534721 gatcactaag ataattccta caatcgcctc actaatgact tcagcttttc cgtgaccaaa 534781 aggatggtct tgatcgggcg gtttattgga aattccgatc actgccaaga ctgcaatcga 534841 agcaacgaca tctgccgcgg aatgtattcc gtctgcaaac acggcttcac tatcgcctac 534901 cagcccaaaa aagacctttc ctgccattaa gatcagattg gcgatcaatg caatcaaagc 534961 aacttttctg cttatttgtt ctctttcact tgccattttt tcctcctata aaactgcaca 535021 aaaaaatagg agtgctctat atacgctctc cgtatccttt cctgtgtaat cactttgttt 535081 atcataccaa ttcaatttcg agtgggtcta tagcaacgtt gtttcctgtt tactaataaa 535141 taaggtgaca gaaaaaaagt tggagctatg ctaaaaaggt catacagcaa acaaatgagt 535201 tcttatgtaa caacagtgat gattcgctat taaaatgctg ccgtcagtga aaaatttcca 535261 cctaattttc aaaaacctat tgacatgaga agatctgtat tttactatta tctcatattc 535321 aagatatttt aatttgagat atttggtcgg aaagatcagc gatcaagcgc aactctaagt 535381 gttcaatcgt tgtcagttct tttacacaat attcaatatg attttttata acataatatc 535441 tcgaattcga gataaaaggg agtgtagcgt aatggctgaa tttactcatt tagtcaatga 535501 aagacgatct gcaagcaatt ttctttcagg tcatccaatc acaaaagaag atctcaatga 535561 gatgtttgaa ttggttgcat tggcaccatc ggcttttaat ttgcagcata caaaatatgt 535621 gacggttctt gaccaggacg taaaggaaaa gctgaagcag gccgcaaacg gacaatataa 535681 agtggttagc tcttctgcgg ttctcttggt attaggggat aagcaggcat atcaacaagc 535741 ggccgatatc tatgaaggtt taaaggtatt ggggatatta aataagcaag agtatgacca 535801 catggtgcaa gacaccgttt cgttttatga aaacagggga gaacaattta agagagatga 535861 ggcgataagg aatgcttcac tttctgcgat gatgtttatg ctgagtgcta aggaaaaagg 535921 ctgggatacc tgcccgatga tcggctttga tgcggaagcc gtaaaacgga ttttgaacat 535981 agacgaccaa tttgaggttg tcatgatgat tacgattgga aaagaaaaaa cagagagcag 536041 aagaccgcgc ggctaccgga agcctgtgaa tgagtttgtt gagtatatgt aaaaggagcg 536101 gataaaaatg gctaaaaaaa cgatgggaat tcatcatatt acagcgattg tcggtcaccc 536161 tcaagagaac acagattttt acgcaggagt gcttgggctt cgtttggtca agcaaactgt 536221 caattttgat gacccaggta cgtatcatct ttattttggg aatgaaggcg ggaagccggg 536281 aacaatcatt accttctttc cgtgggccgg agcccgccaa ggcgtcattg gagacggtca 536341 agttggcgtg acttcgtatg tcgtgccgaa aggggctatg gcattttggg aaaagagact 536401 agaaaagttc aacgttccct acaccaaaat cgagcgcttt ggggaacaat atgtagaatt 536461 tgatgatcct catggactgc acttagaaat cgtggaaaga gaagaaggag aggctaatac 536521 gtggactttc ggagaagtaa cgcccgatgt tgccattaaa ggttttgggg gtgcaaccct 536581 attatcagag cagcctgaca aaaccgctga ccttttagaa aacatcatgg ggctggagcg 536641 agtcggcaaa gaaggagact tcgttcgtta tcgttccgcc ggtgatatcg gaaatgtgat 536701 tgaccttaag ttaacgccta ttggccgcgg gcaaatgggg gccggaacgg tgcatcacat 536761 cgcttggcgg gctaacgatg atgaagatca gttagattgg caaagatata ttgcttccca 536821 cggatatggt gtaactcctg ttcgggatag aaactacttt aatgccattt acttcaggga 536881 acacggggaa atcctgtttg aaatcgcaac tgatccccca ggctttgcac atgatgaaac 536941 acaggaaaca atgggcgaaa aactgatgct gcctgtgcaa tatgaaccgc atcgcacaca 537001 aattgaacaa gggctgctgc cgtttgaagt aagagagtta gattgatttg acacataaaa 537061 aataaagaaa catatattca attgatgatt gctggatggt actgtcagca aagaatcaga 537121 taaaatcaaa gatgaggaga gatacaaatg gaagatgcag gactgttgct tattcgtata 537181 atgattggtg tggtgttttt gttttatggc acacaaaaat tattcggctg gtttggcgga 537241 tacgggatta aaggaaccgg acaatggttc gaatcaattg gggtgaaacc aggaaacgtt 537301 gcggccgctc tatcaggtct tggggagtta gtaagcggaa ttctatttat tttaggcgta 537361 ttcctcccgc ttggagctgc tatcataaca atcatcatgt taggtgctat cgtaaaagtc 537421 catggagcga aaggttttgc gaatggcgcc ggaggttttg aatataacct ggtgctcatt 537481 gcagtttcca taggggttgc actcatcggt tcaggagctt acgctttgca tttttaatac 537541 gaaagtatgt aagaacagtt gctgcttgtc agtaactgtt cttttatttt cacattttcg 537601 gcaagcttgc aggtactctg caaagcaaaa aagcggatat cataaatata aatctgtata 537661 gtgaatgata cgtattgatg agcttggtca tgaaaaacag acctatttga aggagtaaat 537721 ggatgaaaga gatgacagga ttacattcat tagtttctat agaaaacttt atcaaacagc 537781 acaaattcag ttttatttat atatcaaggc ctggctgtac agtatgtcac gcagttctgc 537841 cccagctcag aatagtattg gatcagtttc caaacatcaa attggggcat atcaatgctg 537901 acgatgtagc agaggtcgcc ggcagatttt cagttttcac cgttcctgtg cttcttttgt 537961 tcattgatgg gactgagttt ctaagagaag cccgttttgt tcattttgaa cagcttgaac 538021 aaaagctgaa aagggtttat cgattatatg aaggcgaata aaggaataag gcaaaaaaag 538081 aactcaaatg agttcttttt ttattcttca ctaggcgaag aagggttatc aacctgccct 538141 tgatcacttg tatcattatc acaacttgct gaaataataa ttgaatgaga aggagagtaa 538201 tctcctaatg tgaaattcac tccgtaattt ttgctgttcg cagtatggct gttttgcaag 538261 ttttgtccga tatctgtatt ggcgttttgt gtcattccat ttatcgtgag atttgagatg 538321 ttgatttgag atcgcatgct tcaaaaactc ctttcactca gaagtagctg tcataaagga 538381 cgctggcagt ctatttactt ctatgatatt gcgtttttat atcattgcat caacataatg 538441 gtaaaaataa tagcgagtga atgatcatct tttgaagatg atcaacctat cagcagaaat 538501 aaagccgcct gataaagagg cggcagatcg ttatatgtca tctatgaatt tgatgtatcg 538561 tttttcgttt gcctgaagga taagatagtc gtttttaatg atgagtagga gcctatagca 538621 gcgtagccat aaaaccagcc cataaatacg ccagaaaaga ggctgtgtcg atggcttatg 538681 aaaacagaaa tgacaaggcc tgttattaag gcaactgacg gtacaaaagt tttggggatt 538741 ttcaataata ttttgaggat ttgggttatc aatatgatga ttggaacagc tatcacagca 538801 tcccaaaagt tcgtgtgaat aattggaaaa gccatacggc acctcatgaa gtgtttattt 538861 cttaattttt acgctaaaag cttggaaagc agctcttgga tcgcatatgt tacattttgg 538921 gcttgattgg cggagcttgt ttggcttaaa gcattggatt caaaaaccaa acctgtatta 538981 ctcccaccgg aaccctctgt tgttttagac acagagaacg ggctgatgga aactgcaaat 539041 ccgttattaa aaacgctgtt cccggatatc gaatgaatat aaactgggaa tttcatcatt 539101 catctctcct ctctgttatg actgtttata caatatggtg tgtgagcagc agttgcttaa 539161 acaaaacggc aaaaactttc agtaagagac aaaaacctgc aaaatgccac aagcgccttt 539221 tgttaatgca gctttttagg gacgtttttt ttattttttt tgccaacttc atcaaaaata 539281 ttctgattgc cagactgggc ttgtccgtcc ttatttatga aatcggggtg aatgagtttt 539341 ttcagatccc tgactgttaa aggcttggcg tcatcagtta attctattcc taattgcccg 539401 tttgcctcta atgtcgcaat tttgacatct tgtatagccg taacgccgtg aagccttagc 539461 tgcatttcaa gctggtcagc tgtaagtctc atcttcttta agttttcgat atgaagctgt 539521 ccgttttcaa tgacgatttt tgcttttccg gttaacatct tttcaatggt gttcgatttc 539581 atttggatcc attccataac gatgagtgtg cttgtgaaaa ttgccgctgc aattaatgtt 539641 ttgaagaggc tgtactcgat gattggctga acgataatag ttccgatcga aatcatgaca 539701 accgtttgag tcgacgtcat ttgtgcgatt gatttccttc ctgaaattct cagcaaaatg 539761 accccggcta caatgagaac aagagattcc caagtgaaat tcatgctacc acctgaccaa 539821 tgatgaatta gatttgtcat gggattggct tttcttccgg ccaatcgcaa tttaatatat 539881 ccgaaaggca gtcggttcat tctgtcctga accgaacaat atttttggta tagatggata 539941 tattaagcca aacaatgata gcaacaggag ttttttggcc gaaacaatct gggaagcggg 540001 gagcgccata acatgattga acttgaagtt gtcattagaa cggttgccag ctttggcttg 540061 ctgttaatcg cagaacgaat tttaggcaaa cagacaatct ctcaaatgac gatttttgat 540121 tttattgcgg cgatcacact aggggcgatt gctgccggat tagcttacaa tacttcaata 540181 aaaccgcaca atatggccat ttcgtttagt atttttgtgc taaccatttt tctaatttcg 540241 tttctgtcga taaagaacag gaagctgagg aaattttttg ccggagatcc aacagtgctg 540301 attcaaaacg ggaagatact tgaatcaaat atgaggaaaa tgcgttacac acttgattat 540361 ttaaatcagc aattacggga aaaagaaata tttaatatcg aagaagttct ttttgccatt 540421 cttgaaacga atggtcagct gactgtgtta agaaaaccgc aattccggca tgtgaccaaa 540481 caggatttaa tgattgcggt aaaccaagaa caaaggcttc cgatagaact tattatggac 540541 ggagaaatca ttgagaataa tttaaagcag aatcgtttga cggaatcctg gcttttggaa 540601 gaattgcgaa aaagagacat aaaggtgaaa gagaccgtgt acgcagtgct gctgggtaat 540661 ggggatattt atgtggatca atataaagac catatatcag tccctatgga taaggaatga 540721 aggaacaatc aatcttaaag ccccttattg aacgcaacgg tttcaacttg tcttgggtac 540781 gaaatatgca gaagcccgtt taacagctga atctgtaaca aatgagtttc agcggcttcg 540841 ggaagctgaa tgattcgctc aatttctccg taataccgtt cacgcagcac ttccatttcg 540901 gctggaaaaa caggcgtgat cgttcctttg atcagcagct gggttttaga cagtaaacgg 540961 atcgttaatt cttcctcata cacaccgggc atttccacaa tgataaaatt atattcctca 541021 tcttgataaa agtcgtaaac aaacgtagaa gcttcggaat caaaaaaatg ttccggggct 541081 ttatatttga gcacatttgt ccaaaagtca ctttgtttat attcattcgt aatctcaagc 541141 cactttcgaa ttttttcgaa atccatatga gattctcctt aaatttgatt tgaaatcggc 541201 gcagaagggt ttccgatttg gtcttggtca ctaacgtctg aatcaatatt tccagtgttt 541261 aaaagtgaag acgtaggcga aagatcccct aaggaaaagt ttgctccaaa atatttgctg 541321 ttcgcagtat ggctgttgtg cacagtcgga ccgacatcta tatttccgtt ttgcgtgacg 541381 ccgttgatct taatatttgc gatattaatt tgatatggca tagacgaaac ccctttaatc 541441 taaaattggc ggtggtgcaa tcggaggagc attaacgttg gatgtatcag agttgccgat 541501 agatgtctgg tcatttacat caggatcgtt taagaagttt tccattacgg attctgtagg 541561 tgatgtatca ccgaaagaag agttggtccc ttgagatttt tgattgttgg tagggctgtt 541621 ataagcagct tcgcctattg taattgaacc attgcccgaa atactgttga tcttcaaata 541681 atataggttg attactgtag acggcatccc atcacaccct tccatctttc tgtacagtac 541741 attatgcgcc gctgcaccca attgttcctt gcatttacgg gcaaaactct atctggcccc 541801 ggagtgatgc tcaattatca gtgaatgaaa agccattgat ataggaatca atgaattgat 541861 tcagttattc gaaatgcatg agacctttta ataaaggaag ctggcaaaca ggatcagttt 541921 gaaataattg acaatgaagc taatgccatg aaataatact cgtgagtaac attactcgtg 541981 ggtattattt ttggggtggt cctagttgaa aagtaaagga gtagaaagcc gaaaacgatt 542041 acttaaagct gccgctaatg aattttcggt tcggggattc catgacgcga aggtaagtga 542101 aattgtgaaa aaagctgggt tcacgcagcc ttcattttac ctgtactttc aaagcaaaga 542161 agccatcttt gccgagttaa taaccgattt tcactctcga gtcagaaagc tgacagagtc 542221 acttcttctg gaaaacggat taaacacgga ggatgtgtca aaacgggtac tgctagctgt 542281 agagactgtt tttcaatttt tggatgagga caaggattta accaagatcg gcttttttct 542341 caacccggaa gcaaaacaaa tgaaaaaaga cttggcgatg gttttgaaag agaacttaga 542401 agcagaacag cggcttggct attttcactc tgaactggat atggaaactg tcgctgagtg 542461 tttggtcggc atgattgaac atttaaccga atcatttttg ttaaccggaa tcaaagatcc 542521 ggcaagcctc gcagcagagg ttgtgaatct tttaatttac gggatgcttc cgaaagggaa 542581 tgatgtaaga tgatatctat tatgatgaaa gtcagtttgg cagtttttat gcttgcggga 542641 ggcatcataa aggtaagccg cgttcccttt caagttgagc attggcggca ttatcaatat 542701 ccattatggt ttctgactgt tactggcatt cttgaaatag ccggggcact tgctatgaca 542761 gcgggaattt ggaatcggta tgcagcaatt ggagcaggtg ttctgtttgt cgttctcatg 542821 gcgggagcaa ttcatgcgca tatgtttcga gcaagacaat ctgtcatcat ggcgatacaa 542881 gcgatgattt gtttgattgt ttcaatcatg atcatcatgg ggagttacac gtaagctttt 542941 cactaatgtt taagaacaag cccatttgca ggaaatctcc ttttcttatc gaataataga 543001 aagtccagga attaactgaa tcagtaaaat agagctccat ttctgtgtta ttcgtccggc 543061 atcagctggg ctttttttat aaaggaggaa tacaggatgg cattcacttt ggaagacatg 543121 actgaggaag agttcgaagc ctttcgcggg atgtccgtgc aaaattttgc gaaacaaaac 543181 ataacgtcag gaacttggac ggaaaaagag gcatttgaga aatcggagca ggcatatgag 543241 aacatgattc cgaatgggcg agacagcagc aatcattatt tttggaacat cacaaatgac 543301 caaggagaaa gaatgggctg gctctggctg tatgctgatc cattacatcc gcaaaaggaa 543361 gcgtttatct attcctttgg attgtatgaa gcctttcgcg gaaaaggact tgctcaattg 543421 gcgcttcaaa cgcttgatga aagagcaaga gagcttggtg cggaaaggct ggctctacat 543481 gtatttgcac acaacgagac agccgtctat ctttatcaga agatgggcta tgccatgacc 543541 aatatacgta tgcggaaaca gctatgctga aaagccgctt acgttaccca aatacaacat 543601 gcctatctgg aagcggtggc agggtactat aagtcatcat tagaaagatt aaggtcatgg 543661 gaggcttgaa catataaaga aaaaggacaa cagctgttgt ccttttcaat gccgcttgaa 543721 ctttctccct cagtcttttt tgtcttgatg atccagctct tttattcgtt tcgtaagctc 543781 attgaaagcc tgatcaagct ccttataccc tttatcattt ggcgtcataa aactgagctt 543841 tcccagcact tcttgtcttt ctgtctcaag ctttaaccga agctcctccc gctcatttct 543901 ttctgaagga acgtcgttta actgcttttc gatgccgttg tttgagatga cgagtttact 543961 gtttgttgtt ttttcgagaa agtatcggtc atgtgaaacc gccagcaatg tgccgctgta 544021 ttgtgacagt gtttcttcca gctgttcgcg tgacggcagg tcgagatggt ttgtcggctc 544081 atctaaaatc agcacgtctt tttcctccag aatatatgcc atcagcttga tctttacacg 544141 ctcacccata ctcatatgct tgatcggttc agtccattgg gcggctgtaa aacctaagtg 544201 cctcatcaga ttttgaacgt gcccccttgc tttgaatgtt tcattctcaa ataactcttc 544261 cggtgtttgt tctaaaggca aatcaaacac ctcctgcgtt aaatagccga tgtttgcgga 544321 cggcgacacc catacacttc cttctgctgt ttcctgtccc agaatgatgt tcagtaatgt 544381 cgtttttccg ctgccattgg ggcctatgat cgcaaccttt tcgccgtgct gaattgtaaa 544441 gtttgcgttt ttaaagagag tcctttctcc aaacgctttt gttacattct gaacttctaa 544501 aaaacgtttt cctgttttgt gggttgtatc gattgaaaag cggactgtat attctggggt 544561 aacgggttcc gcctttgctt tttcaagctc tttttcaagc cgcttctgct tggattttat 544621 ctgggcatcc gtacgcttcg cttttacccg gtgatattct ttaaaccctt cctttttcgt 544681 cgattgagca tgggcttttt ccgaccaaga agcgagccca ttcatttgtg cttcaatccg 544741 ttcaaccatt ttttgctgct tttcatattc acgctgctgg gtgagtcttt tcttctcccg 544801 gaacttcata tacccggagt aattcccttt gaattcaatc agcgtctgat cctcaagcga 544861 ccatattttt gttgcggctt cgtctaaaaa atatcgatcg tgagaaacga gaatcacagt 544921 gccgttataa tgtttcagct gttggatgag aaattgcaag cttttttcat caaggtggtt 544981 tgtcggttca tctaacagca gcagatctgc atcctctgat agtcctttcg ccagccgcgc 545041 tttcagtttt tcaccgccgc ttaactgatg aaaatcacga agaggcacat gccatttctc 545101 cagtaacttc ttttcggcag gtgtctgatc cgcaaaggaa tacgccgcgg tttcctgttc 545161 aaccaaagcc agttttatat ccttccgaag gatttgaccc tgtgcagggg ctaagtcatt 545221 gtgaatgagg tgcagcaacg tagatttccc agcgccgttt ttgccgataa tcccaatgat 545281 atctccttgc tgaacactgg cgtttacatg tttaaaaaca gtttgatcct ttacttcata 545341 gctaacgttt gttaatgtta cgatctcttt catccatatc cctcgcttta aagggagaat 545401 aaaaaaatcc tcccaaatgt gttggaagga ttagccgtgc ctgtgcatga tcaaataagc 545461 tattttttat aaatagcagt gtcgtatata tagaaaatgg gcagactaat cctatttttt 545521 gatttgaaat attgatttca aacggtaaaa ataagattag ttaatcattg tccacccatc 545581 atcccttctt gttttgatta caaacactat agcatacctt taaattcaaa agcaaaggtc 545641 attttcatca aaaaaactcc tgctctcatt tttgaggcag gagttttgag tcttattgat 545701 gcttcgcttt tctcacttta taaatcacaa tcagcaaaat aaaccaaacc ggtgtgacaa 545761 ataaggaaac acgagtatcc tgtgccagtg ccagcacaac cagaacaaac gccaggaacg 545821 caagaatcag gtaatttgta aacggataaa gcggaagctt aaacttgttt gttttcgcta 545881 attcaggtct tgttttgcgg tatttcatat ggcagatgac cgtaatcccc caaatgtaga 545941 taaagcatac ggttgaaata cttgtgatca gggtgaatac gccttctggc atgatgtagt 546001 ttaacgtaac accgattaaa atcacgatag ctgaaaagaa taaagcattt ctaggcactt 546061 tacgctgagt cagtttcgcc attgactcag gcgcattgtg atctttcgcc agggaataga 546121 ccatacggct tgtactgaat acagcgctgt tgcatgctga agcagcggat gtcaacacaa 546181 caaagttgat aatacttgca gccccgacga tgccaacagc gacaaatact tgtacgaatg 546241 ggctttcgct gggattgatg atatcccaag gatagatgct cataatcacg agaagagccc 546301 cgatataaaa aagcagcaca cggacaggaa tattgttgat cgccttaggg attacttttt 546361 cagggttttc tgtttcaccg gccgtaagcc cgacaagctc aatgccgaca aaagcaaaca 546421 caaccatctg gaacgagagg ataaacccgt gcatgccatt cgggaacagg cctccgtggc 546481 tccagaggtt tgtgaagctg gacactcctg agcttgtgga aaagcctttg aaaatcatca 546541 caaggccaat gacgattaac gccaaaatgg caatgacttt aatcaaagcg aaccaaaatt 546601 ctaattctcc aaaaagcttg actgtcgcca gattcataat cagtaaaata ataagagcga 546661 ttaagccagg cacccattgc ggcacacccg ggagccaata ttgagtgtag agcccgactg 546721 ctgtcagatc agccatcgca atggaaatcc agcagaacca atatgtccag ccggtgataa 546781 aagctgccat atcgcctagg tagtcttgta caaaatccac aaaagagtga tagttcaagt 546841 ttgataacag cagttcaccc agcgatctca taattaaaaa gcaaatgatc cctgtgatca 546901 tataagcaaa taaaatcgaa ggtccggcaa aatgaatcga tttgcccgag ccgagaaata 546961 agcctgtccc aatggctccg ccgatggcga tgagctggat atgcctgttt ttcaagcctc 547021 tctgcaacgt ttgctgattt atattgtctt tcgtcatgtc gtctgtcact ttatgtgttc 547081 ctccattgaa aattgtttat tgagtcagca atctattttt aatgattatt ataacactaa 547141 aatttctatc ttttttacta aaaaaggatt gatgaaaaga attttaatgt gatttggact 547201 atttcccgaa aaaagcggct ccatttaggg agccgctttt ttatgctttt tcagtttttg 547261 tcataaacag gtagagcccg taatctgtcg gtgcggatgc gtagcctgcc tgccgcagca 547321 ttgctgtgat attgccgcgg tggtatgtcc cgtgattgac aacgtgggga agcagttcgg 547381 aaacagttgt tttcatgatt ccgcttgagg gattttgaat ctggagtggc ttattgagct 547441 gttctttttg ctgtaaaaat agtatatagc gctcggataa cctcagaaaa aggtcttcca 547501 tttcctctat ttctttagcc tctgtctgtt ctttaagctg ttcagctaaa gccaacgcat 547561 cgctcaaggt tttgccggaa aacacttcaa tccagccgag atcagaaaga taaacatgag 547621 acaatacatg ggatattgac ggaaacacgc tttgaatttc ttgatggtat atctcttttg 547681 gaagctcttt taatcggttg aatatttgtt gattggccca gacgttatat tcatacaatt 547741 tgaatgcaaa atctgacatg ttaaaattcc ccctttcgtg tgtatagctt tcattataca 547801 cgaacatgag ttcttatgta gagtgctcga aaataaaatt tgttgacata tatagtttag 547861 aggaataaac taattgacat tgaacataaa gtttagcggg gtaaactata atgcgtctga 547921 ttagagctca tttcataaat tcttgttttt tgcagcacac ctgtcgactc aagaagcagg 547981 ttatccagca ggtcagtaat taagtttccg tggttataca cccacgaccc gttccacgga 548041 ttgccccctg catcaacagg aagggaactt tgcgctccaa taatataatg atgaggatta 548101 gcatgtttaa ccgcttcatc aagtggcgct tgatctgtac cttgactgcc gacaccttca 548161 ccgcctgatt catctaataa agcattgatt gtgttttgaa ccagttcaac gtgggcaatc 548221 tcctctaaaa aaatgccgcg aagcagatcg cggtactgtt tctgctttcc tctgaaatta 548281 gagctttgga aaaaaactgc atcattgtac gcatttctcc gtaatgaccg cctaatatct 548341 cctgcaggac cttagcagct gccgggtctg gcttgtccgg tttaatgata ttaatcagtt 548401 cctctttgta gtaatacata acacgcctca tttcttctta agagattttc ttatattatt 548461 tgtaagatga gataaaatat atacatgata agcatgggaa ggcgtgaaag aagaaaataa 548521 aaaaatacag gaaaagtgtt gaccaaataa aacaggcatg gtatattatt aaacgtcgct 548581 gatgaacagc gtgaaacaaa acagaaaaac aaaaaagttt tcctaaggtg tttacaagat 548641 tttaaaaatg tgtataataa gaaaagtcga attgaaaaag attcgaaaaa acattaaaaa 548701 acttcttgac ttcaacatca aatgatagta tgatagttaa gtcgctcaat aagcgcccgt 548761 agctcaattg gatagagcgt ttgactacgg atcaaaaggt taggggttcg actcctctcg 548821 ggcgcgccat ataagatacc acgcgggtgt agtttagtgg taaaacctca gccttccaag 548881 ctgatgtcgt gagttcgatt ctcatcaccc gctccattat tgaatgatct ttgaaaacta 548941 aacaagacaa aacgtacctg ttaattcagt ttttgaaaat cgcacagcga tgtgcgtagt 549001 cagtcaaact agggcctgca cgatgcaggt cacacaggtg tcaccgcggg atgcggtgga 549061 cttaacctgt gatccattta tcggagagtt tgatcctggc tcaggacgaa cgctggcggc 549121 gtgcctaata catgcaagtc gagcgaacag atgggagctt gctccctgat gttagcggcg 549181 gacgggtgag taacacgtgg gtaacctgcc tgtaagactg ggataactcc gggaaaccgg 549241 ggctaatacc ggatggttgt ttgaaccgca tggttcaaac ataaaaggtg gcttcggcta 549301 ccacttacag atggacccgc ggcgcattag ctagttggtg aggtaatggc tcaccaaggc 549361 aacgatgcgt agccgacctg agagggtgat cggccacact gggactgaga cacggcccag 549421 actcctacgg gaggcagcag tagggaatct tccgcaatgg acgaaagtct gacggagcaa 549481 cgccgcgtga gtgatgaagg ttttcggatc gtaaagctct gttgttaggg aagaacaagt 549541 accgttcgaa tagggcggta ccttgacggt acctaaccag aaagccacgg ctaactacgt 549601 gccagcagcc gcggtaatac gtaggtggca agcgttgtcc ggaattattg ggcgtaaagg 549661 gctcgcaggc ggtttcttaa gtctgatgtg aaagcccccg gctcaaccgg ggagggtcat 549721 tggaaactgg gaaacttgag tgcagaagag gagagtggaa ttccacgtgt agcggtgaaa 549781 tgcgtagaga tgtggaggaa caccagtggc gaaggcgact ctctggtctg taactgacgc 549841 tgaggagcga aagcgtgggg agcgaacagg attagatacc ctggtagtcc acgccgtaaa 549901 cgatgagtgc taagtgttag ggggtttccg ccccttagtg ctgcagctaa cgcattaagc 549961 actccgcctg gggagtacgg tcgcaagact gaaactcaaa ggaattgacg ggggcccgca 550021 caagcggtgg agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac 550081 atcctctgac aatcctagag ataggacgtc cccttcgggg gcagagtgac aggtggtgca 550141 tggttgtcgt cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct 550201 tgatcttagt tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga 550261 ggaaggtggg gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta 550321 caatggacag aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc 550381 tcagttcgga tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg 550441 atcagcatgc cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga 550501 gagtttgtaa cacccgaagt cggtgaggta accttttagg agccagccgc cgaaggtggg 550561 acagatgatt ggggtgaagt cgtaacaagg tagccgtatc ggaaggtgcg gctggatcac 550621 ctcctttcta aggatattat acggaatata agaccttggg tcttataaac agaacgttcc 550681 ctgtcttgtt tagttttgaa ggatcattcc ttcgaaacgt gttctttgaa aactagataa 550741 cagtagacat cacattcaat tagtaataca agatatcaca tagtgattct ttttaacggt 550801 taagttagaa agggcgcacg gtggatgcct tggcactagg agccgatgaa ggacgggacg 550861 aacaccgata tgcttcgggg agctgtaagc aagctttgat ccggagattt ccgaatgggg 550921 aaacccacca ctcgtaatgg agtggtatcc atatctgaat tcataggata tgagaaggca 550981 gacccgggga actgaaacat ctaagtaccc ggaggaagag aaagcaaatg cgattccctg 551041 agtagcggcg agcgaaacgg gattagccca aaccaagagg cttgcctctt ggggttgtag 551101 gacactctgt acggagttac aaaggaacga ggtagatgaa gaggtctgga aaggcccgcc 551161 ataggaggta acagccctgt agtcaaaact tcgttctctc ctgagtggat cctgagtacg 551221 gcggaacacg tgaaattccg tcggaatccg ggaggaccat ctcccaaggc taaatactcc 551281 ctagtgaccg atagtgaacc agtaccgtga gggaaaggtg aaaagcaccc cggaagggga 551341 gtgaaagaga tcctgaaacc gtgtgcctac aagtagtcag agcccgttaa cgggtgatgg 551401 cgtgcctttt gtagaatgaa ccggcgagtt acgatcccgt gcaaggttaa gcagaagatg 551461 cggagccgca gcgaaagcga gtctgaatag ggcgcatgag tacgtggtcg tagacccgaa 551521 accaggtgat ctacccatgt ccagggtgaa gttcaggtaa cactgaatgg aggcccgaac 551581 ccacgcacgt tgaaaagtgc ggggatgagg tgtgggtagg ggtgaaatgc caatcgaacc 551641 tggagatagc tggttctctc cgaaatagct ttagggctag cctcaaggta agagtcttgg 551701 aggtagagca ctgattggac taggggcccc taccgggtta ccgaattcag tcaaactccg 551761 aatgccaatg acttatcctt gggagtcaga ctgcgagtga taagatccgt agtcgaaagg 551821 gaaacagccc agaccgccag ctaaggtccc aaagtatacg ttaagtggaa aaggatgtgg 551881 agttgcttag acaaccagga tgttggctta gaagcagcca ccatttaaag agtgcgtaat 551941 agctcactgg tcgagtgact ctgcgccgaa aatgtaccgg ggctaaacgt atcaccgaag 552001 ctgcggactg ttcttcgaac agtggtagga gagcgttcta agggctgtga agccagaccg 552061 gaaggactgg tggagcgctt agaagtgaga atgccggtat gagtagcgaa agaggggtga 552121 gaatcccctc caccgaatgc ctaaggtttc ctgaggaagg ctcgtccgct cagggttagt 552181 cgggacctaa gccgaggccg aaaggcgtag gcgatggaca acaggttgat attcctgtac 552241 cacctcctca ccatttgagc aatgggggga cgcaggagga tagggtaagc gcggtattgg 552301 atatccgcgt ccaagcagtt aggctgggaa ataggcaaat ccgtttccca taaggctgag 552361 ctgtgatggc gagcgaaata tagtagcgaa gttcctgatt ccacactgcc aagaaaagcc 552421 tctagcgagg tgagaggtgc ccgtaccgca aaccgacaca ggtaggcgag gagagaatcc 552481 taaggtgatc gagagaactc tcgttaagga actcggcaaa atgaccccgt aacttcggga 552541 gaaggggtgc tctgttaggg tgcaagcccg agagagccgc agtgaatagg cccaggcgac 552601 tgtttagcaa aaacacaggt ctctgcgaag ccgtaaggcg aagtataggg gctgacgcct 552661 gcccggtgct ggaaggttaa gaggagcgct tagcgtaagc gaaggtgcga attgaagccc 552721 cagtaaacgg cggccgtaac tataacggtc ctaaggtagc gaaattcctt gtcgggtaag 552781 ttccgacccg cacgaaaggc gcaacgatct gggcactgtc tcaacgagag actcggtgaa 552841 attatagtac ctgtgaagat gcaggttacc cgcgacagga cggaaagacc ccgtggagct 552901 ttactgcagc ctgatattga atgttggtac agcttgtaca ggataggtag gagccttgga 552961 aaccggagcg ccagcttcgg tggaggcatc ggtgggatac taccctggct gtattgacct 553021 tctaacccgc cgcccttatc gggcggggag acagtgtcag gtgggcagtt tgactggggc 553081 ggtcgcctcc taaaaggtaa cggaggcgcc caaaggttcc ctcagaatgg ttggaaatca 553141 ttcgcagagt gtaaaggcac aagggagctt gactgcgaga cctacaagtc gagcagggac 553201 gaaagtcggg cttagtgatc cggtggttcc gcatggaagg gccatcgctc aacggataaa 553261 agctaccccg gggataacag gcttatctcc cccaagagtc cacatcgacg gggaggtttg 553321 gcacctcgat gtcggctcat cgcatcctgg ggctgtagtc ggtcccaagg gttgggctgt 553381 tcgcccatta aagcggtacg cgagctgggt tcagaacgtc gtgagacagt tcggtcccta 553441 tccgtcgcgg gcgcaggaaa tttgagagga gctgtcctta gtacgagagg accgggatgg 553501 acgcaccgct ggtgtaccag ttgttctgcc aagggcatcg ctgggtagct atgtgcggac 553561 gggataagtg ctgaaagcat ctaagcatga agcccccctc aagatgagat ttcccattcc 553621 gcaaggaagt aagatccctg aaagatgatc aggttgatag gtctgaggtg gaagtgtggc 553681 gacacatgga gctgacagat actaatcgat cgaggactta accatatttt tgaatgatgt 553741 cacacctgtt atctagtttt gagagaacac tctcaatttg tttggtggcg atagcgaaga 553801 ggtcacaccc gttcccatac cgaacacgga agttaagctc ttcagcgccg atggtagtcg 553861 ggggtttccc cctgtgagag taggacgccg ccaagcatta cttttatcat cgcggggtgg 553921 agcagttcgg tagctcgtcg ggctcataac ccgaaggtcg caggttcaaa tcctgccccc 553981 gcaaccaaat atatggttaa ataaggagtg ccctaagggt gcaaccaaaa taatcctata 554041 caaatatggt ccggtagttc agttggttag aatgcctgcc tgtcacgcag gaggtcgcgg 554101 gttcgagtcc cgtccggacc gccattaatg taaacgaaac gatcatgttt tcgttttttt 554161 tgtgttttct tttactgtat cttctgcttg gtgtcatagc caagctttct ttatatcggg 554221 aacatcttgg atattccagc aaaattcgat aaactaggaa gagcacaaat aggcataagc 554281 agggttgaaa ggaggttttg gttcatggat gaatttgatt tgatacatag cattactccg 554341 cggaccattc accattcttc cgttgatgta ggaataggtg atgatgcagc gctctacact 554401 gcgaaacacg gcgttcagga aattgtttgt gttgatacta tggtagaaga cgtgcacttc 554461 aaattacact attcctcacc tgaagatatc gggtacaagg cgttagccgt taatataagt 554521 gatattgccg cgatgggagg cattcctaag ttttatctgg tatcacttgc ggtaccttca 554581 aaatggactg aatctgaaat caaggcgatg tatgaaggaa tgaatgaact ggcgaaacta 554641 tatcatatgg atctgattgg cggcgataca gtttctaccg ctgacaaatt agtcgttaca 554701 gtcactgtaa tcggtgaaat tgaaaaggga caggcctgtt tgcgcagctt ggcaaaaccg 554761 aatgatattg tgtttgtaac cggtgaaatc ggttcttctg cagcagggct ttctttattg 554821 ctggaagaga ctaatcctca aaactcatct gtggaaacgg attactttat ccacaggcat 554881 aaacggcctg agccaagagt aagcgtcggc agattatgct cgatttttaa acgggcagct 554941 ttaaatgatg ttagtgacgg attggctagt gaactgaacg agattgcaga agccagctgt 555001 gtttcaattg aaattgttga aagcatgctt ccaattcatt ctgatttgcc taagcttcat 555061 cctaactgga aagaatgggc tttgtttggc ggtgaggatt ttgagctgac agggacggtt 555121 tcaaatgagg agtgggaagt gttgaagcag gagtgcgcag cgcttcatct tcccattaca 555181 aagattggct atgtcaggga aaaaacaaaa tctaaagtga tcctaaaaac agatcaaaca 555241 tcaatgatct tagagaaaaa gggatataat cattttaaat aagacgggtg actcgtgtga 555301 agcaattaaa atggagaact gtaaatccag aagaaacaaa agcaattgcc aagctgacgg 555361 cagcgtttgc taaaccggga gacgtcctga cattagaggg cgatttaggt gcaggaaaaa 555421 cgacttttac gaaaggtttt gcagaagggc tgggaattac acgtattgta aacagtccga 555481 cttttacaat tataaaagaa tataacgatg gcgtacttcc tctttatcac atggatgtgt 555541 atagaatgga agatgaaagt gaagatttgg gacttgatga atattttcac ggacaaggtg 555601 tctgtctcgt tgaatgggct catttaattg aagaacagct gccacaggag cgactgcaaa 555661 ttgtcatcaa aagagctggt gatgatgagc gggaaattac ctttactgct gtcgggaatc 555721 ggtatgaaat gctttgtgag gagttaagta gacatgacaa tattagcaat tgatacatca 555781 aattatacat tgggcattgc gctgcttcga gaagacactg ttatagcaga atacattaca 555841 tatttgaaaa agaaccactc tgtaagagcg atgcctgctg ttcattcatt gctgaatgat 555901 tgtgatatgg caccgcagga cctttctaaa attgtcgttg caaaaggccc tggttcatac 555961 acaggagtaa gaataggtgt gacgttggcc aaaacacttg cctggtcttt agacattcca 556021 ataagtgctg tatcaagtct tgagacgctt gcggcaaatg gccggcattt tgacggtctg 556081 atcagcccaa tctttgatgc tagacgggga caggtgtaca caggtctgta tcaatataaa 556141 aatgggcttt tagagcaagt tgttccagat caaaatgtga tgctggcaga ttggctggag 556201 atgctaaaag aaaaggaccg ccctgttttg tttttaggcc atgatacttc tcttcacaag 556261 cagatgatcg aggatgtgct tggaacaaaa ggattcattg gaactgccgc ccagcataac 556321 ccgcgccctt cagaattggc ttttctcggg aaggaaaagg aagcagctga tgttcatggg 556381 cttgtcccgg attacttgcg gctggcagaa gctgaagcga aatggattga aagtcaaaag 556441 tagggtgata ggatgaaaac aaaagcagcg gtcagaaata tgcggcttga agatatagat 556501 cacgtatacg aaatcgaagc atcctccttt acgtctcctt ggacgaagga ttcgttttat 556561 catgagctgc tggaaaatcc gtatgctcat tatctcgtga ttgaaaagga cggccatctt 556621 gctgggtatt gcgggatttg gattgtgatg gacgatgccc agattacaaa tatagcgata 556681 aaaccagagt atcgcggcca gtctttagga gaaacgcttt ttcgctcagc tgttgaactg 556741 tgcaaagaaa aagacgcaag gcggctttcg cttgaagtga gggtttcgaa tcatcctgct 556801 caaggcttat ataagaaatt cgggatgcag cccggcggaa taagaaagaa ctattatact 556861 gataacgggg aagatgcgtt aattatgtgg gtgacgataa atgagtgagc aaaaagacat 556921 gtacgtatta ggaattgaaa caagctgtga tgagactgct gcagctattg tgaaaaacgg 556981 gaaagagatc atttcaaacg tagtagcctc tcaaattgaa agccataagc gcttcggagg 557041 cgttgttccg gaaattgctt caagacatca tgttgaacaa atcactttgg ttatagaaga 557101 ggcgtttcgc aaagctggca tgacgtatag tgatattgat gcgattgcag taacagaagg 557161 tccgggactg gtgggagcgc ttcttatcgg agtgaatgcc gctaaagcat tgagctttgc 557221 atataacatt ccgttagtag gcgttcatca tatagccggt catatatacg cgaaccgtct 557281 tgtagaagac atcgtgttcc cggcactggc attggtcgtt tcaggaggcc atacagaact 557341 ggtttatatg aaggaacatg gatcatttga agtcattggg gaaacccttg atgatgcggc 557401 aggagaagcc tacgacaaag tggcgcggac gatgggattg ccatatccgg gtggaccgca 557461 aattgacaag ctagctgaaa aagggaatga caatattccg cttcctcgcg catggcttga 557521 agaaggctct tacaacttca gctttagcgg attgaagtct gcggtgatca atacgcttca 557581 taatgcatcc caaaaagggc aagagattgc tccggaagat ttgtctgcca gtttccaaaa 557641 tagtgtgatc gatgtcttgg taaccaaaac ggcgcgcgcg gcaaaggaat atgatgtcaa 557701 acaggtcctt ttagccggag gagtagctgc aaacagaggc ctcagagctg cattagaaaa 557761 ggaatttgcc cagcatgaag ggattacgct tgtcattcct ccattagctt tatgcacgga 557821 taatgctgcg atgattgctg ctgctggtac aattgctttt gaaaaaggaa ttcgcggtgc 557881 atatgatatg aatggccagc ccggccttga attgacttct tatcaaagtc tcacgagata 557941 atagcgtgag actttttatc tgtttgttat taacagacaa ttcacaattt atccacatat 558001 ctgtgagtaa ttatagagat attgatggat aaagggctga ggtcactgtt aataaagtgg 558061 ataaattcag aatattttgt ggatagtgtg tataaagcgc ttactttgtt tatttattag 558121 gggatgttct gtggataaaa agcacctcta aaaagaggtg cttgactttt ttaatcttct 558181 tctgtggata gttcttccca ttcggacaaa agagattcca gctcctgatt aagcttctca 558241 ttgtctgcat ggatagcttg tactttttca tgatcctgat agacttcagg gtcacatagc 558301 aattcatcat tgcggctgat gttctcctca atggtttgaa cggtggtttc aatttcttca 558361 atccgacgga gtcgttggcg ctctttcttt ttccattctt tttcttcctc gtaggaacgt 558421 ttggagtcag acttcactgt agctggcgtt ttatcagttt cctcttgctg attcattttc 558481 tccaattcaa gctgctctgt ttttttctct gtataataat cgtaatctcc cagatactcc 558541 tctatatggc ttgaagaaag ctccaatact cttgtggcga ttctgttaat aaaatatctg 558601 tcatgtgaga caaataacag tgtgcctgga taatcaatca gcgcgttttc gagaacttct 558661 ttgctgtcta aatccagatg gttcgtcggt tcatcaagga tgagaaagtt ggctttttga 558721 agcatcagct tagctagagc caatcttgct ttttcgcctc cgctcagtga atgaactggt 558781 ttcagcacat catctccgga gaataagaaa tttccgagac acgttctgat ttctttttct 558841 gggagcccgg ggtactcgtc ccacagctca tcaaggacac gtttagagga agtcaactca 558901 gcctgttcct ggtcataata gccgacactg acatttgagc cgtaagaaat tgttccctga 558961 tctggtttta gggtgtctat taatgttttc agcaatgtcg atttacctat tccgttaggg 559021 ccgacaagcg cagcgctttc tcctcttgtg agcatgaatg acacttctgt taaaagcggc 559081 ggctggtttt catagctgat tgtgagatcc tgaacacgaa ggacttcatt tccgctctgt 559141 tttgtaatat caaaatgaaa gtttgcggat ttttcatcgc caagcggttt tgacatgaca 559201 tccattcgct caagctgctt tctgcggctt tgcgcccttt tggtggtaga ggctctcgcc 559261 agatttcgat ctacgaagtc ctgcagcttt gcaatctcgt cctgctgctt ttcatacatt 559321 ttcagatctt tttcatactg cgcggctttt tggtcgagat aagcgctgta gttgccgtga 559381 tactttttgc tttctgctct tgatacctcg tatacctggt ttactacttt gtccaaaaag 559441 tagcggtcat gcgaaacgat gagaatggcg cctgaatagc cttgtaaata atgctcaagc 559501 caggtaagcg tatcaatatc cagatggttt gtcggctcat caagaatgag caaatcaggc 559561 tgtgttaata gaagcttacc taaagccagt cttgttttct ggcctccgct gaggctttga 559621 acctgtgtag aatcgtcaaa atggctgaag ccgagaccat gcagcacaga tctaacatcc 559681 gcttcatatt gataaccgcc tttatctttg aattcctgct gaagacggtc gtaggttttc 559741 atgatgcttt ctaattcacc cgggtcagct gccgccattt tttcttccat agcccgcatt 559801 tccttttcca ttgcttttaa gtggtcaaaa acagtcagca gctcttcttt tatggtaagc 559861 ttagaatcca agccagtatg ctgggcgaga tatcccattg taatatcttt cggtttaata 559921 atttcgccct tttcatacga aagctggcct gcgataattt taaggagcgt ggattttccg 559981 gcgccatttc ttcctacaat ggcgatgcga tcacgatttc tgacttccag ctttatattg 560041 tttaaaatag tatcagcacc aaatgatttg gacagctgat taacttgtaa gatcatcata 560101 ttatttcacc tctgctataa taagttaagt gtagcttatg aaccagaagt cagcaaacaa 560161 tacattggcc atataagaca tagagaagaa aatagtgtat gatctgttta aggagcgttt 560221 taatatgaat ggattttctc attttaatga acagggcaga gcccagatgg tggatattag 560281 cgaaaaatct tcgactgtcc gtactgcggc ggctgtttca agcgtacaca tgaagaatga 560341 agtgtacgag aaaatacaaa gtcacgatat cggcaaagga gatgtactgg ctgtcgcaca 560401 ggtggcaggc attatggccg caaagcaaac gtcgaatatc attccgatgt gccatccgct 560461 ttcattgagc ggggtagata tatcgtttga ctggaaaata aaagaagcag aagttatact 560521 tcatataaaa gcacaggtca aaacgaaagg gagtacaggt gtggaaatgg aagcgctcac 560581 ttctgcatcg gtgtgcgctc ttaccgttta cgatatgtgc aaggcccttg ataagggaat 560641 ggtcatcggc cctactttct tgctggagaa gacaggcggg aaaaacggtg actttaaaag 560701 agaactatcc gagtataatt tggaggacca aaaatgaata aggatcaatc aaaaattccg 560761 caggcgacgg cgaaacggct gccgctttac tatcgctttt taaagaatct gcatgcgtca 560821 ggaaaacagc gtgtatcatc cgctgaactc agtgatgccg taaaggttga ttctgccacg 560881 attcggaggg atttttccta ttttggagct cttggcaaaa aaggatacgg atataatgtg 560941 gattatttgc tgtctttttt ccggaaaacg cttgatcagg atgagatgac agacgtcatc 561001 ttgattggtg tcgggaactt gggaacggca tttcttcact ataatttcac aaaaaacaat 561061 aacacaaaaa tttctatggc ttttgatata aatgagagta aaataggaac tgaggtaggc 561121 ggcgtgcccg tctataacct tgatgacctt gaacaacacg taaaagatga atcagttgcc 561181 attcttacag tgccagcagt tgccgctcaa tccattacag acagattggt cgcattagga 561241 atcaagggaa tccttaattt tacgccggcc cgtttgaatg tgccggaaca cattcgaatt 561301 catcatatag atttagcagt tgagcttcag tcactggttt attttttgaa gcattattca 561361 gttttagagg aaatcgaata gagggaaagg aggagcccaa atatgccgat cggtcctgga 561421 agccttgctg ttatcgcaat cgttgctctg attatcttcg gtcccaaaaa gctgcctgaa 561481 ttggggaaag cagcgggaga cacacttcgt gaatttaaaa acgctactaa aggattaacg 561541 agtgatgaag aggaaaaaaa gaaagaagat cagtaagtta ggatgacacg aatgaaagtg 561601 aatcaaatgt cgctgctgga gcatattgct gagcttcgaa aacggttgct gattgtagcg 561661 ctggcgtttg tcgttttctt tattgctgga ttttttttag caaagccgat tattgtgtat 561721 ctgcaagaaa cagatgaagc gaagcagctt acgcttaacg cgtttaacct gacagacccg 561781 ctttatgtgt ttatgcaatt tgcgtttatc atcggcatag tcttgacctc gccggttatt 561841 ctttatcagc tttgggcttt tgtgagcccg ggcctctatg agaaagagcg caaagtaacg 561901 ctcagctaca ttccggtctc tattttgctg tttttagcgg gcttatcttt ttcatattat 561961 attttatttc cttttgttgt tgattttatg aagcggattt ctcaggactt gaatgtcaat 562021 caggtgatcg gaattaatga atattttcat tttcttctgc agctgacgat tccgtttgga 562081 ctgctgttcc aaatgccggt catcctcatg tttttgacaa ggctcggaat tgtgacaccg 562141 atgttcttgg cgaaaatcag aaagtatgcg tattttacgc tgctggtgat cgcagccctg 562201 attacaccgc ctgagcttct gtcccatatg atggtcacag tcccgctttt gattttatat 562261 gaaatcagta tccttatatc gaaggccgct tatcggaaag cacagaaaag cagtgctgcc 562321 gatcgggacg tgtcttctgg gcaataataa aaaatccatt tctcatgcga gaaatggatt 562381 ttctttattt ttggttcttt ttgattttaa atgaaaaggc gaacatctta aaagaaatgc 562441 tgatgttgta agcggcgaac accatcagca ggatggagta aaatgaccac atgctgcctg 562501 gcgagcttgc ggcaagataa gtaaagatgc accctacggc aaagtagatc attccccaaa 562561 ctaccgggtt tctcataaaa ataatcctcc aataatcaat tgcatttgtg tgctctgctg 562621 ttcaaggtaa ttacgaacag gctcaagctg catgatgacg acgaatgtat tcatcattaa 562681 atgggcgaaa atcggcaccc atatccgttt tgttctcgca tataaaaagg caaaggtaaa 562741 gcccattgct gtatatagaa ggagatgctt caaatcagcg tgaacaatac cgaagataac 562801 cgagctgatc agtcctgcga aaaagaaatt cgttttttcg tacagcgcgc cgaaaatgat 562861 ttttctgaag atgatttctt ctaatatagg cccgacgatg gaagaaacga taatcatgag 562921 cgggactgcc tgaatgacat ccagaatcgc ttgtgtattt tctgattctc ttccgatgcc 562981 aaaaacataa tattcaatag agcctgctat tccttgagag aaaagggcaa tgaaaaaacc 563041 ggctatcgcc caaaggatag aaagtccgat tgagtccttc tgtccgtttc gcagcgtttc 563101 tttcggaacg gttctcagaa tgagcagaac aacaacgaga caggcgataa agctgataac 563161 ggaccataat ccttgtgcat gcagcatatt ttcatctgta ggctgtcctc cggcataacc 563221 gaatttaaat aacaagggaa tcgcgattaa tgcggaaaac tgcatgatga tatatgtcaa 563281 aataataaac caatactgtt ttctcaaatg gtatgtactc ctttgttaag tgggtttcgt 563341 tcatctacag ctattgtaac ataatcggta cgggggtgaa aaagctaacg gaaaagggag 563401 cggaaaagaa tgatgtaagc gtgaaaaatt ttttatctta tcacttgaaa ttggaaggga 563461 gattctttat tataagaatt gtgttagcac tctttagtgc tgagtgctaa aattacatat 563521 tcatactatt gaggaggtta tttcattgtt aaagccatta ggtgatcgcg ttgtcattga 563581 actcgtagaa tctgaagaaa aaactgccag cggaattgtg ttgccggatt ctgcaaaaga 563641 aaaaccgcaa gaaggcaaaa tcgtggcagc tggttcaggt cgcgtgttag aaagcggaga 563701 gcgcgttgct ttagaagtaa aagagggcga ccgcattatc ttctcaaaat acgcaggtac 563761 tgaagtgaaa tacgaaggta ctgaatactt aatcttacgt gaaagcgaca ttttagctgt 563821 tatcggctaa ttcttaaata aacaatactt aaaacatttg aggaggtctt gtaaacatgg 563881 caaaagaaat taagtttagt gaagaagctc gccgcgcaat gcttcgcggt gtcgatgcac 563941 ttgctgatgc tgttaaagta actttaggac caaaaggacg caacgtggtt ctagagaaaa 564001 aattcggttc tccgttaatc acaaatgacg gtgtaacaat cgctaaagaa atcgagctag 564061 aagacgcgtt tgaaaacatg ggtgctaagc ttgttgctga agtagccagc aaaacaaacg 564121 acgttgccgg tgacggtaca acaactgcaa cagttcttgc gcaagcaatg atccgtgaag 564181 gccttaaaaa cgtaacagca ggcgctaacc ctgtaggcgt gcgtaaaggg atggaacaag 564241 ctgtagcggt tgcgatcgaa aacttaaaag aaatttctaa gccaatcgaa ggcaaagagt 564301 ctatcgctca ggttgctgcg atctctgctg ctgatgagga agtcggaagc cttatcgctg 564361 aagcaatgga gcgcgtagga aacgacggcg ttatcacaat cgaagagtct aaaggcttca 564421 caactgagct tgaagttgtt gaaggtatgc aattcgaccg cggatatgcg tctccttaca 564481 tggtaactga ctctgataag atggaagcgg ttcttgacaa tccttacatc ttaatcacag 564541 acaaaaaaat cacaaacatt caagaaatcc ttcctgtgct tgagcaggtt gttcagcaag 564601 gcaaaccatt gcttctgatc gctgaggatg ttgaaggcga agcacttgct acacttgttg 564661 tgaacaaact tcgcggcaca ttcaacgcag tggctgttaa agctcctggt ttcggtgatc 564721 gccgtaaagc aatgcttgaa gacatcgctg tccttactgg cggagaagtc atcacagaag 564781 atcttggcct tgacctgaaa tctactcaaa tcgctcaatt gggacgcgct tctaaagttg 564841 tcgttactaa agaaaacaca acaatcgttg aaggcgctgg cgaaacagac aaaatttctg 564901 cccgtgtgac tcaaatccgc gctcaagtgg aagaaacaac ttctgaattc gacagagaaa 564961 aattacaaga gcgtcttgct aaacttgctg gcggcgtagc tgtcatcaaa gtcggcgctg 565021 cgactgaaac tgagctgaaa gagcgtaaac ttcgcatcga agacgccttg aactcaactc 565081 gcgcagctgt tgaagaaggc atcgtatccg gtggtggtac agcgcttgta aacgtatata 565141 acaaagtcgc tgcagttgaa gctgaaggcg atgctcaaac aggtatcaac atcgtgcttc 565201 gcgcgcttga agagccaatc cgtcaaatcg cacacaacgc tggccttgaa ggatctgtca 565261 tcgttgagcg cctcaaaaac gaagaaatcg gcgtaggctt caacgctgca actggcgaat 565321 gggtaaacat gatcgaaaaa ggtatcgttg acccaacaaa agttacacgc tcagctcttc 565381 aaaacgctgc gtctgtagct gcaatgttct taacaacaga agctgttgtc gctgacaagc 565441 cagaagaaaa cggtggcggc gcaggaatgc ctgatatggg cggcatgggc ggtatgggtg 565501 gaatgatgta ataaagggat attaaccctt atacatcaat gttttaaccg tcttaaaaaa 565561 ctagacaaag cgtgaataaa aaaagagaag gtctttcatc agtttactaa actgttggga 565621 gaccttttct ccatattagc ggtcatatga gcataaatgt ccatcgtcgt atttatgtcc 565681 gaatgaccaa attgttgctg gatttcttta atgcctactc ctgcctcaat tagtaaggag 565741 gtatgggtat gcctaaaaga gtggggggtg acattctttt tatcccagct tttttgagca 565801 gccgtttaag tctagtctca ataacctttc ttaattgcgg atgaccatcc tcccgctcaa 565861 aaataaatga tgagtcttga taaatcaatc tatttttaag cttaatttca ttttgataaa 565921 ttttattttt ttttagtaga ttgacatcgt ttcatcaatt cgaacgatat caacagatcc 565981 tgttgtttta ggtgttagca attggtattt ttcaatttga ttgttagggg tgtatagggt 566041 ctttgtgacc tggcttatca ttgaaatctg tccattttaa agcaagaagt tcaccaattc 566101 ttaggtcggt ctaggcaagt acggtaaaga ccaaatggtc catttctagc ccgtcagatt 566161 gagcgagctt tagaaaatgt gtcagcacct ctttttccaa tgctttgttg cttcttgggt 566221 aattgaaaat ccccagttgg gttcatttta ataatccctt gagttttagc ttttcggaaa 566281 atcatacggc cgcaggcatg aatacctccc aaacaattgt gactgtattg ctcgttcagt 566341 tctaacgtgc ggtcttcata catttttttg tgttttgcta atcgggtatt gacccaatac 566401 tgcgataaaa tgcatcattt tcttttcact ggcccgtaca ctgcttattt ttaccccact 566461 ccggttgtaa atcttaagcc aaccttttgc aaatgttttg aagggcatat ctgactcctt 566521 aataaaagtc ccgttgtcgt tttggagttc tacgtgacgg gctgctactg gggcttcttt 566581 ctttgtttta aatcttcctt tggatatttc tagacgtttt ttggttaaag ggtcaatgcc 566641 tagtagatat gataactcca cgtcttaccg cattgcttga gttttgccat ttatttgtcc 566701 ctaactaatt ttttttcatc aaattggtct ttaagtgagt ttaataattt ttgtttctct 566761 cgactggtca ataattgccc ttcatatttc aaaagattgg ataaatttga gatggaatca 566821 atcctgatgg atggtaccgt agactttaat aagaaacgaa aggccaactg cgacttcagt 566881 tggcctttcc tatttataat aaagaaattg agtgagattg ctgacagaac tacgtactac 566941 tcgttttctt tagttgccct tgctaatcgt tcaacctctc cccgaatccc aatcgcaggc 567001 tcccacgaat caatcaaacg aatcgccttc tgattagatt ccaccgcttt cgttttctct 567061 cctttacgat acaacagctg cgccattccg tagtgatagt agatcagttc aacttgattg 567121 gcgttatgtt tgtcatagag catttgctca aaggcttctt ccgctttttc aaactgatca 567181 catttcacgt aagcgacacc cagattgaaa taggcttcta tcgttttttc gccgccgtat 567241 gtggagctga tttcatttgc cgcttcgtat aattgaatgg cttctacatg ataacctctc 567301 gcaaagctta agtcaccgcg aaccaataga actctgtgtt gaatggtagg ggaaatcggt 567361 tgattttcga tttcgtttaa aattgtctct gctttttcct gttgcccgtc ttttaaaaac 567421 agccttgctt tgagtgcatg tccccaaacc tttagatcat aggcatcgtg agcgtctgat 567481 tgttcaagaa tcttcagccc ggcttctatt tgctgaagcg ctccgtctaa atcattgact 567541 tccatcaatg cccagcctga ggtgtcgatt cggaagtacg cttctcgtgt gtgttggcct 567601 aagtgatggg cggcgtcggc cgctttgcgt ccgtattcga ttcgcagggg caggttgatt 567661 ctgcttagaa aatggctaat gcgggtgatg agttcgatta ggatttcttt ttgttcagtt 567721 tcacttgccc attggatgac ctttaagatg tttggccatt cttgtttcat ttgatctaag 567781 ttccgtccca gcaggtagct ccaatagata gagttgggct gttcccgctt taaatgggtt 567841 tcggcataat caatataata gtgcgcccag cgattgcggg cttctttttc atattcgtgc 567901 tgttcggaca agtgctgttc tccgtaagcg acaacggttt ggtgcgctaa gtattgtgtc 567961 ctgccttggc ttcgttccgg ctgaatcagc gcatatgacc gcatttgttc catagcgtaa 568021 tgaaaacggc gggcgtctaa tccggctgct gccgccaggc ttttttcatc aggcggcttg 568081 ctgaaaaagc aaagcgtctg ccagagcttt cgcgtatctt cattgcatct atcccaggtg 568141 cggccaaaga ggaattcaaa caattccagc agtgagtagc ctgcttttcc aagctcatga 568201 atcagctgct gagcggggat gtcatcgtct gacatatagg caatgctgag tgccatggct 568261 ttcgggtttc cggcagtcgc tgaaatgaat tcgtttttca ggtcagatga tagatgtaac 568321 agctgctcca gcttttcccg tttacgtggg aggttgcatg tttgtaagca gtgatgcact 568381 tcttgttgaa aaaattcgtg ggcatctgtt tggtcaagac cgcttagctg aatggctgtc 568441 atttctccga agctttcccg ataagtttgc tttacgtttt cccgcgctgt aaggagaact 568501 tttacgcctt gcggaaggct ggtgataaat tcatgaatgt cacgttctgc agtatcaatg 568561 ctgtcaacga tcagcaggat cggtttttct ctagtgtaat tggctaacgc attgcggacg 568621 acaaaccgtt ttacattgat tgatttatcg atttgttctt tgcgtccgag ctgataggcg 568681 atcgtattta aaaaatcgct aaagcttaat cctttccaat cagcgctgac ccagatgatg 568741 ctgttgaatg ccggccaaac tgaagtatcg tcgacacagg aataggcggc ttcaagagca 568801 attgtggttt ttcccatgcc ggcccagccg gtgattaaac agactggtga tggagaaagc 568861 atccattgcc gtatcgcttc catatcaaag ctgcgtccga taaagcgtcc ggaccagcgt 568921 gagggtaaat tatgcgtgat gggctgttct gtaagcgcat tcgtttcttg gccgggtctg 568981 tcatgaaaca gccgttttac tacattttca atttcgcctt cactcggagc cccgaataat 569041 ccgtcttttc gcagtatttt cgcttttttc aaacaggatg ctgcccatac aggcaatgcg 569101 ggtttgatga ctgggatagt ggtggcttcc agcaagtcgg tcaaccactc gatatccaag 569161 tcggtctttt cgagaatgat ccagatcatt ccgaacagtt ttccgtcgtc gattcttccg 569221 ggaatgtagt ttgcccccat ctgtccgatc cagcttttga tcgtgtttgg ggagactccc 569281 agctggagtg cgattttatc tatgtaagac tgtcctgttt tttcattctt tttccttctg 569341 actttataat caggatgaag ttttagcgtt ttgacgccag gtgccagcat ttgtgcaaat 569401 tgttttcggt tttcaagttc agccataagc ctgcacctcc tattagtact attttatcaa 569461 tccagcgttt tttgtatatg aaaaaataaa agtacagtgc cgctgtcctt ttatacagca 569521 ggaaaggctg ttgaacgtgt taaaaagcag ataaaatggg ggcagtaaca gagaaaacaa 569581 aaatgtatgc acttacattt tattttctaa agaaaggaac ttgccaaatg actcacacag 569641 tacctcaaaa catgaaagcg gctgttatgc acaacacaag agagatcaaa attgaaacat 569701 tgcctgtgcc tgatatcaat catgatgaag tgttgattaa ggtgatggct gtcggaattt 569761 gcggatctga tctgcattac tatacaaatg gccgaatagg caactatgtt gtggaaaaac 569821 catttatcct tgggcatgaa tgtgcgggtg aaattgccgc tgtcggatca tctgtcgatc 569881 aattcaaggt gggagaccgc gtcgctgtag agccgggtgt tacgtgcgga cgctgtgagg 569941 cgtgcaaaga aggacgctat aatctttgcc cggatgtaca gtttttggct acaccgccgg 570001 tagacggtgc gtttgtccaa tatattaaaa tgcgtcagga ctttgttttt ttaatcccag 570061 actcactttc ttatgaagaa gctgctttga tcgagccgtt ttctgtcggt atccatgcgg 570121 cggccagaac gaagctacag cccggatcaa cgattgcgat tatggggatg ggccctgttg 570181 ggttaatggc tgttgccgca gctaaagcat ttggggcagg cacaatcatt gtcaccgact 570241 tagagccgct gcggttagaa gctgcgaaaa aaatgggagc gactcacatt attaatatac 570301 gtgaacagga tgcacttgaa gagattaaaa cgatcacgaa tgatagaggc gttgatgttg 570361 cttgggaaac agcagggaat ccagcggcat tgcaatccgc actggcttct gtgcgccggg 570421 gcggaaaatt ggcgattgtc ggtttgcctt cacagaacga gattccgctc aacgtgccgt 570481 ttattgcgga taatgagatt gatatttacg ggatcttccg ttatgccaat acgtatccaa 570541 agggaatcga atttcttgct tcaggcattg tggacacgaa gcatctagta acggaccaat 570601 attcgctgga gcagacgcaa gatgcgatgg agcgggcgct tcaatttaag aatgaatgtt 570661 taaaagtgat ggtgtatcca aatcgctgag tgaacaggga ggatcttcgt attctccctc 570721 ttgtttactg gaaatgaaaa cggattcttg gggtgggaaa tgatgattgg aacagaaaaa 570781 gtaacggcat tgaaggcgaa gcatcagtca aaatccagca ccggcctgtc ctggtttgaa 570841 cgaatcggtt atggattcgg cgatatgtcg tataatatta tctttcagtt tgtaaacgca 570901 tacttattat tttattatac agacgtcggc ggcattcagc ctgcggtaat cgcaactttg 570961 tttcttgttg tgcgtgtgct ggatgctatt tttgacccga tcatgggatt gattttagat 571021 aaaacgaata caaggtgggg aaaagcaagg ccatatttgc tgtgggtggc atttcctttt 571081 gcgctattca cattcttatg tttcacgacg cctcatttcg gtgagaccgg aaatatggta 571141 tatgcgtatg tcacttatat tctgcttggg atgtccttta gtatgcaaac gatcccggtg 571201 aacagcttaa cggggcggat gacgaattcg gtggaggaac gaacggttct gaccacaacc 571261 cggatgattt tggtgtatat cggcattctt ttatccattt cctgtgcgac accgcttgca 571321 actgctatcg gaggagagga tcaggcgttt ggatttcaga tgacggcgct catctatgcg 571381 gctgtcagca tcgttttgaa tctatttagt ttctttactg tacgggagcg gattcagcct 571441 aaaaagagaa aaaaacaagg gatcaaaaag acgttatccg ttttattcaa aaacaaaccc 571501 ttgctcatgt taatttcatc atttttggct tttgcgatcg ggtttaatat taagctcagc 571561 acgatggtgt attattttac gtataacgta aaccataaag agttcgtgtt tatgggcacc 571621 gttttatttt tcggggcagc gctgatcagc aatttgttta ttcctttctt ttctgagaag 571681 tggggcagaa aacaagtcat gattatcacg gcagctctat cgcttatttc ttatgccggc 571741 ctgcatttta cgccgtattc ttcaattcca ctcattttca tttggctttt cgcttcggga 571801 tttttcacaa cgcctttaaa tacgcttgct tggggaatgg ttgcggattg cgtcgattat 571861 gcggaatgga aaaccggaat tcgcgcggat ggtgttgtga tttcgagcat gagctttatt 571921 aataagctgg gtgttgcgtt agccgggtca ttttcggcca tttatttagg aatcgccggg 571981 tatgtggcga atacagacca gacagttgcg tcgttgaatg cgattaaaaa tatgaatgct 572041 ttgattccgg gatttttcat tttgctttct attattctta tcgccttcta tcctttaacg 572101 gaaaaaagat ataaacacat catctctgag ctggagcaaa ggtctgcgag ataaatagat 572161 gtaaaatttt taatattcaa tgttgtattt atggcaaaaa gtaatatact gagactgtaa 572221 tctagacttt ataaatgagt gtgataatat gcgtagtcat tctgtagttt gtattgggga 572281 attgttgatt gatttctttt gtaccgatgt tgacgttgat ttaatggaag ggcgccaatt 572341 cctgaaaagt gccggcgggg caccggcgaa tgtgtcggca gcgattgcca agctgggcgg 572401 agacgccgct ttcagcggaa aagtaggaaa ggatccgttt gggtattttc tgaagcgaac 572461 attggacgct gtacatgtcg atacctctat gctggtgatg gatgagaaag cgcctacaac 572521 gcttgctttt gtttcattaa aacaaaatgg agagcgtgac tttgttttta atagaggcgc 572581 ggacgctttg tttacgctgg aggacattga ccaggaaaaa ctaaacgaag cgaaaatcct 572641 tcatttcggc tctgcgacgg cactgttatc ggatccgttt tgctcagcct atttacggtt 572701 gatgtcgatt gcgaaagaca atggacagtt tatttcgttt gaccctaact accgtgaaga 572761 tttatggagg ggaagagtct cagagtttgt aagtgttgcg aaaaaagcga tcgctgtaag 572821 tgattttgtg aaagtcagtg acgaggaact tgagattatc agcggtgtga aggatcatga 572881 aaagggagtt gcgatccttc atgagatcgg agccaacatt gtcgctgtga cacttgggaa 572941 aagcggaacg cttctttcca atggaaaaga ccgtgaaatc attccaagca ttccggtgac 573001 atcaattgac tcaacagggg cgggagatgc ttttgtcggt gcggctttat atcaattggc 573061 aaacacggat cagattcaat ctgtagatgc tgattttgtg aaactgcgtg agattgtggc 573121 gtttgccaat aaggtcggag ctcttgtgtg cactaaaatt ggagcgattg atgcactgcc 573181 gagtttggat gagattggag tttctttgta aatcattgaa gatgtttctt gaaagtcttt 573241 ggacttttgg gggcatcttt ttttattgct tacatttttg ttcaggtaaa aagttgtata 573301 ttttttgttt gaaatgtcat tttttattaa aaaagtgaaa cttttaacga taataaatag 573361 tatatgtaac aagggttacc gaattagctt taggaggaac gatataatga gtataattgg 573421 aagatttaaa gatattatgt ctgcgaatat caatgcttta ttggacaagg ctgaaaatcc 573481 ggagaaaatg gtagatcaat atttaagaaa tatgaatagc gatttggcta aggttaaggc 573541 agaaacagca gctgttatgg ctgaggagca gagagcaaaa agagaatatc acgaatgcca 573601 ggcggatatg gaaaagatgg aaagctatgc aatgaaggcg ctgcaagccg ggaatgagag 573661 cgatgcgaga aaatttcttg aaagaaaaac atctttggag tcaaagcttt ctgagctgca 573721 ggcggcgaat caaattgctg caaccaatgc cgcacagatg agaaagatgc atgacaaatt 573781 ggtatctgac attggagagc tggaagcacg caaaaatatg atcaaggcga agtgggcagt 573841 agcgaaaacg caagaaagaa tgaacaaact gggcgcttct gtttcaagta caagccaatc 573901 aatgtctgca ttcggccgaa tggaggacaa agtaaataag gcacttgatc aggccaatgc 573961 aatggctgaa ctgaacagcg ctccgcagga tgatatggct gatctgtctg caaagtatga 574021 cactggcggt tcaagccagg ttgatgatga acttgcggcg ttaaaagcga aaatgatgct 574081 cgataagtaa tacataggag gccgcagctt tcggctgcgg cgtcatttta tcataaaatg 574141 tgagagggaa cggtaatgat aatatcttat aagtgtccga actgcggcag tgatatggca 574201 tttgacagtg aaaccggctc gttatcctgc agcagctgcg gaagacagga caatattgaa 574261 agccttccga aagaaaacat tgcggcacgg ttttctgatg atgaagcaaa agaatatcaa 574321 tgtaaaaact gcggtgccgt tttgatcacg gaagctgaaa cgacagcaac gacgtgcagc 574381 ttctgcggag gtgctgcaat acttgccgat cgtttatcag gacatttggc gccggcgaag 574441 gtcattccat ttacaatcag caagcaagaa gcggagcagg catttcgaaa gtggtgcaaa 574501 aaaggccttc tgacaccaag aggtttcatg tctgctgatc gtatcaaaag catcaccggc 574561 atgtatattc cattttggat gtttgattta aatagtgaag tacaggtgag agcaaactgt 574621 accagagtcc atcaatatga agaaggggat tatatttgca cggaaacaga gcactttgaa 574681 gcgtttcgtg atatcaatct cgattatttg aaaatccctg tcgatgcctc tgaaaaaatg 574741 aaagacgaat taatggacaa attggagcct tattcatacg aagagctgaa ggactttcaa 574801 acggcatatt tggccggtta tattgcggaa aagtacaatt ataccgatga ggagcttttt 574861 ccgagggcaa aagagaaaat cagcagttat atagattcat acatccattc tactttttcc 574921 ggatatacgt cagtcaatgt gagggacaaa catattcaca cgaaaaacgt gaacagcttt 574981 tacgttttgc ttcctgtttg gatggtcagt tacgattatg aaagagcgga gcatatcttt 575041 gcgatgaacg ggcaaacagg aaaggtcgtt ggaaagccgc cgatcagtcg aggaaaagtg 575101 gctgcatggt ttagcggaat agcaggcggg acatttcttg cgttgaagct cgtctcattg 575161 atgatgggag gcggattttg atgcgtggat tttttgggaa agcgatcttt gttgtgctgg 575221 ctgttttcat catgatgcct ttactgggta tcgaagcggt aagagcctct gaattgcagc 575281 agcatgtgta cgatcgcgct catctattgt caaaagcgga gatcggaaaa cttgaatctc 575341 tctcggcaaa gctgggtgca aagagggaca ctgatttcat cattattacg accaaaagca 575401 caaacggtga agatattgca gactataccg gcgattttta tgatcgttac ggaaaaggca 575461 gtacagccat tctgacgatt gatatgacaa acagagaagt gtttatcgca ggctttaaaa 575521 aagccgaaca gtatttggac aacagcaggc tcaatagcat cagaaatacg atttcatctg 575581 atttatccaa tgaaaattat tttgaagctt ttgagacata tattcagctt tcctataaag 575641 atatgggcat aaaaccggga gtaaaccctg acaacatatt ctttacatgg tggtttcagc 575701 tgattgctgc catcgcagtc gggggaattg cggtttcaat catgctttat catgcaggcg 575761 gcaaagtaac ggttaatgga agtacatata tggatcagcg tacgtctgat gtgattgatc 575821 aatacgacac ttatattaga acgactgtaa caagagaaag aaaaccatca gataaagaca 575881 gcggcagcga tggcggtgtt acgaaaggcg gcacgtcata cagtgggagc cggggcagtt 575941 tttaaatgta agaaatagag aaagggagag gcgtaatgtc gtttttcaga aatcaattag 576001 cgaatgtagt agagtgggaa gaatttagag atgatatgat tttttataaa tggaacaatc 576061 gtgaaatcaa aaaagggagc cgtttaatca ttcgtcccgg acaggatgct gtctttttga 576121 acaatgggcg ggttgaagga gtctttcaag atgatggcga ttatgatatt gaatcagaaa 576181 ttattccatt cctttcaacg ttaaagggct ttaagtttgg ctttaacagc ggcatgcgag 576241 ctgaggtgct gtttgtcaat acgaaggaat ttaccgtaag atggggaaca aaacaggcga 576301 taaatattcc ggcagcggga atgccaggcg ggatgcccat tcgcgcaaac ggcacattta 576361 atttcaaggt gcaggactat atcagcctga ttgataaaat cgctggcgtg aaagatcaat 576421 attttgtaga ggatattaaa acccgtatca tttctattct ggatcagctt ctcatgaagt 576481 ggatcacaag agaagggaaa gatatgttta atcttcaagc aaacgctttt gatattgcca 576541 agggaattca agaggactta gatatgcaat taataagcga cgggatgacg gtcactggtt 576601 ttcaaatcat gagctttaat tatcctcaag aggttcaaga tatgattaca aagaacgctt 576661 cctacggtat ggttggggat gtgaacagat accagcaaat atcaatgacg gatggaatgg 576721 catccggaaa gatgagcgga agcggagcgg cttcggatat ggctggaatg atgatgggaa 576781 tgaatatggc caatcagatg atgaaccaaa tgaatcagaa tcagcaggca cagtcatcag 576841 gcccacagtc aactggcagc ggaagcaaac cgaatttctg tccaaactgc ggaacaaaaa 576901 cgggcgaagc caatttttgt ccgaattgcg gccagaagct tgtataagaa tcatacagtg 576961 aaaagtccgg agtgatcagc actcgggact tttttattta ggagaataag cattacctat 577021 tgcttgctcc tgaacaggcc attttcgagc ccccgcttgg ataattccca gcagcaattg 577081 acgacgttcc tttattgaat tgacggcaat ttgaaatgtt tgctttgata aagccggtat 577141 gcctgattgt tgaagctttg agatgtctgg ttctggcggc gcttgttctg caggatggat 577201 ataggcagta tgaacggtat ccagatagtt tttgatactt gagcgcgctt ctttgatatg 577261 aagctgattc ggctgatatt gttcaggaat tccgtatttg aaaatggtta gagcctcatc 577321 caatacagca acagctataa tggatgattc ctgatgctgc gtgctgtggt aaaaatgaag 577381 gatggggaag gcgttatgct gagcggtcag ctttcccagt tctgatgagg cagcgacaag 577441 aagaaaatca atgtcgtgaa aatctttgcc attccatgca ttatggacga tttcagttcc 577501 gtcatgccct agacttaata cactttgggc aaaggagcgt ttttgattaa ccgcactcaa 577561 gacggaaatc aaatacgtga cagaaaatgt gatggtaagc agtccttgag ctgtttcaat 577621 aatcgtgaca agcttccata ggcctccgtt cggagcgagg tcgccatttc ctaatgtaaa 577681 catgacatag ccggaaaaat aaattcggtc tgaccaggaa gccggttctt ttgattgagt 577741 ttccataagt gagtgagggt cactcgagta aatcaaaacc cacccgctcc aaaatagact 577801 gatccatatc actaacgtca ggcataacag cagaggacca gccatactta gaacctttgc 577861 gtggtcaccg ctgattttgc ggcagccctt ccacagccag gcagacaggc atcttgtgat 577921 cgggccggca ccgctctcta accataacgt ggtccataaa aaatcaatca tccccgctgt 577981 caataataaa aggcctgcaa tgatataacc ctcattcatt ttggttgcct cccttaagtc 578041 agccttcttt tattttcttc tctatttcct tttatcctga gtctgaaaca attgaacgaa 578101 tgtttgattt tacagagaaa aataggtggg agttacccaa cacttactca tttttcaata 578161 tgaacagaaa atcacaagat ttttgacttg attcacacat tttcatgaag aaaaacgttc 578221 attttcccct tgaattggtg attttccttt tatagagtaa aaaattttca gaaatttata 578281 ttgactgaaa gcgtttttat aattatgata atatcagata taacaaaaat gtcactataa 578341 catcactaca attgaactat taagtgacta ataaatacca aatgaacgag gttatgcaca 578401 aagaaatgac cattgttctt ttaacgagaa atgaaatcgc ttccataggg attgacatgc 578461 taagaagaag ggaaggttat gaggttattg gataaaaaca tgaacaacta ttttctgaag 578521 cctgcttacg aaatgtgagg aaggcagcag ccctggaata agtttttgac atacgcattt 578581 tgaaaaagac tgggggaaac agtatgaata aacaaggaaa tcaaatgtca tttttacgta 578641 caattatttt agtctccact ttcggcgggc ttctttttgg ctatgatacc ggtgtgctca 578701 atggagcttt gccgtatatg ggagagccgg atcagcttaa tctcaatgcc ttcacagaag 578761 gccttgtcac cagttcactt ctttttggag cggcactggg tgctgtgttt ggcggcagga 578821 tgtctgattt taacggccgc cgcaaaaata ttttgttcct cgctgttata ttttttattt 578881 caacgattgg gtgtacgttt gcaccaaatg ttacggtcat gattatttcc cgttttgtgc 578941 tcggtattgc ggttgggggt gcatccgtaa cggtgcctgc ctatttagca gagatgtctc 579001 ctgtggaaag caggggacgg atggtgacgc agaacgaatt gatgattgta tcaggacagc 579061 ttttggcctt tgtttttaat gcgatccttg gaacaacaat gggagacaac tcccatgtgt 579121 ggaggtttat gctggtcatt gcgtcacttc cagccttgtt cctgtttttc ggcatgatca 579181 gaatgcccga gagtccccgt tggcttgttt ctaaaggaag aaaagaagat gctttgcgtg 579241 tattgaaaaa aatcagggac gaaaaacggg cagcagctga gctgcaagaa attgaattcg 579301 ctttcaaaaa agaagaccag cttgaaaaag cgacatttaa agatctttca gtcccatggg 579361 tgcgccgtat tgtgtttatt ggattaggga ttgcgattgt acagcaaatt acaggtgtga 579421 attcgattat gtattatggg actgaaattc taagaaattc cggtttccaa acggaagccg 579481 ctttaatcgg aaatattgcg aatggcgtga tttcggtatt ggcaacattc gtcggaatct 579541 ggctgctggg aagagtgggg cgccggccga tgctgatgac aggcttgatc ggtacgacaa 579601 cagcattatt gctaatcggg atattctcac ttgtacttga aggatcaccg gcacttccgt 579661 atgtagtcct gtcattaacg gtcacatttc ttgcttttca gcagggcgcc atttcaccag 579721 tgacttggct gatgctatct gaaattttcc cgcttcgcct tcgcggactg ggaatgggtg 579781 ttacggtatt ctgtctgtgg atggtgaatt ttgcagtcag tttcacgttt ccgatattgc 579841 tggcagctat cgggctgtcc acaacgttct ttatcttcgt tggattagga atttgctctg 579901 tcttgtttgt gaagaggttt ttgccggaaa cgaaagggct ttcgcttgag cagctggagg 579961 aaaacttccg cgcttatgat cacagcgggg caaagaagga ttctggggct gaagtgattg 580021 gataatttaa aaaagaatcc gcacccgagt gcggattctt tttggtttca aattagttag 580081 gtctaacaag gattttgact tggcttttct ctttaataag agccccgaag ccttcctcga 580141 tcaaatcatc tagtacgatt tttttcgtta cgagtttgtc ggctgagaaa tagccttctt 580201 tcattaatga caatacagcc gggaagatgt cgcggtatcc gataattcct tttactgtac 580261 gttctttgat tacgatatcg ttcggatgga tttcagcacc tttttcccaa atgctgacga 580321 tgacggtttc accggcaatt gtagtggact ggatggcttg tcgtaacacc actgggacac 580381 cagtgacttc gaatgctacg tcaacaccgc ctcctgtacg ttctgcaatc tcagcgacta 580441 catcgtctgt tttagacgga tcaacgatga tcgcgccaag ctcctcagct ttttgctggc 580501 gttcaggaga aagctcaaca gcgtaaatat cagttgcacc ggcagccttc agcgcttcaa 580561 tgacaagaag tccgatcggg ccgcagccga atacagccgc tttgtcgcct gctttgagtt 580621 tgcttgagcg gacagcgtat agagcaactg cagaaggttc aacgagcgcg ccttgttcat 580681 atgataattc atcaggaagt ttgaacaaaa gctcttcatc cacagagacg tattcagaga 580741 aaccgccgcc tccgccggct aagccgagga atcccatttg ttcatcaagg ttgtaggcgc 580801 cttggtggcc gtgtgtagca aaaatcggct cgactacaac gcggtctcca actttataat 580861 tttcaacgcc ttctccgact tcgacaactt caccggagaa ttcatgcccc attgtgacag 580921 gtgccgtttc atttgttaat gggtgcggtt tgtcaaccgg aataaagatc gggccgccca 580981 gatattcgtg taaatcactt ccgcagatgc cgcaccattt gactttgatc tttacttttc 581041 ccggctccgt ttttggctct tcgatatgtt caatacggat atccttttgg ttatgccatc 581101 ttgctgcctt catggattac cactcctata acttttgatg tgagtaattc cgcaccggtc 581161 aatatgaact gttcacaaaa tcgccatttt taaaaccaaa aaagaaatga aatttttata 581221 taatataatc tacgtttttt tgaaaaaaag aaactttaaa gaaaaaaggg tctcgcacac 581281 tcttttttct ttatatgaga gtatcaatcg tttacatagc tatgaatttg gtttgaacaa 581341 tacggtaatg gttcgttcat attgaatgcg acaactactc tatcaataat tataactcta 581401 atactgctat tataatagga taatcttcca tggtttattt tagcagaggt aacttttttg 581461 actttgtaac attactgtaa ggatattgaa ataaaaaata gctggttgat cgtgtataat 581521 cttcctagat gttaacaaac agggggacga aatgttgaag aaagtcattt tagccgcttt 581581 tatcttagta ggaagtactt tgggagcttt tagtttttca tcagatgcca gtgcgaaaca 581641 tgtgaacgga aatattactt ggtataatgg agtcgggaaa aaaggctctt caggtaagaa 581701 acttggacat tgggattgtg cgaccaaaat cggatttgat gttcctagaa acgggacaaa 581761 aatcagagct tatgcaaaag cgaagcctaa aaaggtgatt acggtttata aaaatgatgt 581821 tggcagaatg cctaatgcag tgctggatgt tagccctaaa gcgtttaaag cgcttggata 581881 cccattaagc aaaggtaaag tagcggggca ttacagctat taatgtacat atataatctg 581941 gaaagcaaga agtcacattc ttgctttttc tattggtgga gataaaagat gaaaaaaaga 582001 atcatattat tattagcagt gataatagcg gcagctgccg cgggggttgc gttttatgtt 582061 gcaaaggata aaggccatga gaaggctgct gatgtttcag tcaataccga aagcggtgat 582121 gagctgctgg tttcaattac agatacggat ctgctgacaa agtattatga aaatgacaag 582181 gtgatccatg aggagaagct gaccagctat ccggcatttg ccttggatca aaaacagcag 582241 gtgctctatt atacgggcaa taatgaacag aatgaaatga ggctttttaa attggatctg 582301 aagtctcata aaaaaacgat gctttataaa ggcgcggaga gtgcggacag tttattttta 582361 tcaaaggacc gttcaaccat ctatttccgc ttaggaaaag cggacgaaag caattttcga 582421 atcgccgctt ttgatctgaa gacgaaaaag tataaaaatc tttatcctgc cgctaatgat 582481 caggatgaca ccgtcagcag cttcttttat aaccaaaaaa acgattcatt tgcattgctt 582541 cattattctg tagaagaaga ctacaagaaa acagatgaag caaacgaaaa gggcatcgac 582601 cctgaaccga caacgattca ttttgcggaa ggccgccaaa ataaatttaa tgagctgaaa 582661 agcctgaacc aatttatcag cgatattgct gtttctgatg atgataaacg tattttattc 582721 acatcatata cgcaaaaagg aacggagcaa accgcttcta ttcaaatgct caatgcggat 582781 acgaaaaaat atgaaagcat catctcaaat caaaaatcat ttaagctgtt aattgacgca 582841 cagcctcagt tttctaagga tgggaagaac atttattttc ttgccgaagc caagggggct 582901 aaaaagctga aggacgaaac agggcgtgaa gctaaggtgc ggacgattta ttcctatagc 582961 cttgagaata agaccttcaa aaaagtatgg gaaaatccga acggcatcat caacagcttt 583021 tttgtgatta actaataaaa accactcggc atgagctgag tggctttttt aatggatgag 583081 gtgcagggct aatgatccga gccatttaaa gatatgaatc agaggtaccg acaaaaacag 583141 aagttcaaca tatgagttca ttgcaacatt cagctttttg aacgcagctc tttttttcaa 583201 gtctttttgc tgctggtttg agatcacgtt atcactcctc ttatatccat attataccat 583261 taaaacagac aaaaaagccc taaacgttta cagttttggg cttctttctt cgtatttggc 583321 ctcttgcaat gagaggcttt tattctgaaa tatagaattt tgtctccgtt cggggtttgt 583381 ttgcttgcgg gagactgcat ttgttatagg gaagaactag cttgttttcg tttggctgtt 583441 gttttggaga ttcactaatg aacggatgcc gtcgaccatt ttacttccgc acaaagggca 583501 caatggcgta tcactgctgg cgaagttttt tcgggtccag ccattacagt cttcttttgt 583561 gcattcccaa gtactcacat cttcctttgg cagcggttct tgatttcgtt tgttatagta 583621 agacataaag tcacttcttc cctcatgtat tttactgcac atttcctatt gtctcatact 583681 tttccctaat ctcctaattc ctttttcttt atgactttcc aataacccca tctaaaaagg 583741 agaggagtgt gctgttaaaa gcatctggct cttctaaaaa cgggcaatgg ctgcttttag 583801 gaaaggtaac gagtgtcgcg tttggaatat tgctgcgcaa gtgttcccca gctgctgtag 583861 agaaaaattt cttgtcttcc ccgaagcaca gcaatgccgg cacattgatg ttttggaggg 583921 tgccccggta atcagcggcc gtttggttaa ataaaatcgt gctagaaatg gcagccggct 583981 gtttgaggat ttctgccagc atccattctg tttcggtctc ggcaggcggt tctgcgaaca 584041 tattctggat gaagctttcg tagaaaggca gcgggtcagt ttgaatggcg tgcatcgctg 584101 tttttaagcc gtcaaaatca aatggaccat gttcccagcc ctcccattga tagtccgaag 584161 cggattgatc gatgatcaca gcggcttgaa tgttatcatt cccaaactga ttgagataat 584221 cccatacgac aaaagcaccc attgaccagc cggcaagaac gacatgatca agctccattg 584281 catttagaaa ttcccttatg tcacgggcat attgggaaat ggtgtggccg tgaagcactt 584341 tgtcagattc gccgtgtcct ctaagatcaa gacgaataca ttgataattg gcagaaagca 584401 ccgaaaattg tttgtggaaa aattgtccgc tcatcagcac cccatgtata aacaggatcg 584461 gcgtcccgct cccgtgtgtt tcatagtaaa ggcgtgtctg atcttctaat atgatgtatg 584521 gcatgtttct cctcctttag tttccatcat gagtatggct ggctgctgtt gagctgatga 584581 tggcagctgt cgcggctgcc tgctgcgctt gaatgactgt ttcgatagcg gtgtatagtc 584641 ctgattccat cagcagattt ttctccatat gctcactgag atagaggctg acagcaattt 584701 taaagttcat ttccttttgc catttaaaag ctttttcctg gtttaattcg tcagtgatgc 584761 acaaaacggt tttgatatct ggctcttcca gaaatgtgag gagagcaagg tctggataat 584821 gataatcctt tgtttttttg acagattcag tgatcgattg atatatctgt ttgcaagcgg 584881 aaacaagcat ttcgggctct ttttcacttt gcaaggccag aatatggctg acctgatgta 584941 agtactgtcc ttttttaaag ccgttggctg ccagcagttg atagcatgtt tccgccttct 585001 gtagcgcctg caaacctttt ccgttttctc caagcagtac ggcaagcgga acattctgag 585061 ttgaagtgag gaaataatga tttttcttca tctgctgata aacagctagc cccatgttca 585121 tctgttcttt ttggtttgtc gtttcagatt tgccggtgag caagatcaga gcggaaaggt 585181 atgtgaacat atcccgctta taccctagct tcaccatttc attgtataca tcgatgaaag 585241 tctgaaatgt ttgttttgcc tcatgctgaa aatgaatgtc cagaatagat gcaacagtaa 585301 agcggtggtg tgaattgagt gttgagaagc tgccgatgtt tgatttgata tagctgctca 585361 aatcataaaa gcgctgaaaa tcaaactctc ttttattcac aatatatgca gaagaaatga 585421 gcattaatat ctgatcgtgt gaaactttcc attttaattt tgtttttaat tcagcataaa 585481 tggaaatgta atgctttgtt ttttcatgta gatcgtgtgt gagcataaaa agcagctcct 585541 tttgttgttt ttacgtaata cgataaatag ggccaaaggt ttcataaaga aaaaacttgc 585601 ctgctagagg caagtttgtc gggttattta tggggatcag ttatatccat cggtctcatc 585661 atgtcatagt cttcatgctc tagaatatgg caatgccata cgtatcgtcc gctgtacgga 585721 ccgaatgtcg ccgcgattct caggacttca cctgcatgcg cttgaatggt gtctttccag 585781 cccttttcac ttggcggcgg cgggacagcc ggaccggtat aggacaattc cccgctttct 585841 tgataacggg cgatatcaaa cggccgccgg tctaatacac ggaaggagac tagatgcagg 585901 tggatcggat gtgttccgcg tgtcgggttg ataatggacc atatttcagt tgtgccgact 585961 tttggtgttt ctgtgacggg atcgtgccag cgtttgttat taagcagaag gacgggtctg 586021 ccgtattcgt cctgggtgcc tgccagtttt aacgttctga tgttttgtat tctttcatgc 586081 tgtaccgaag ggtatgaggc gaggtacttc ggctttctgc tttcgtcttt ttgtgccaat 586141 ggttttgtga ctctgaattg catgatattc gcatctgttt caggattgac gtcaccgccg 586201 cagcccgcgc tgtttgccaa aatgatcgat tctccttcat atgctgtgaa gtcaatgatg 586261 atatcgtaac gttcagcagg cgcaaggctg aaagaattca gtttaacaga tcgcggcagg 586321 agccctccat ctgaaccaat ctgaataaaa tctccgccat tatcgagtga caggttatag 586381 gttcttgtat tggaggcgtt gatgacacgg aatcggtatt tccttggctc gacttccaag 586441 tatggccata ccttcccgtt gacgagtatg gtttctccgc aaaaagccgg aacgattgaa 586501 ggattaggca gtgacggaga agggttttcc ggtgcgctcg gataaaacaa agaaccatcc 586561 tcattgatcg tgcggtctgt gataagaagc ggcacatcgt attcgtctga aggcagtttt 586621 aagcgttttt cctttgggtc atgaatgata tatgcaccga caagtccggc atagacattt 586681 agcctggtga gcgccatggc gtgatcgtga taccacaata tagccccgcg ctgctggttt 586741 ggataatgat aaacctctct tttgaaataa ggtcctgttt gttcaaagtc tttggaaaac 586801 caagcctccg gatacccgtc actatcatct ggcgtgacgc cgccgtgtaa atgaacaaca 586861 gtctttacct cgggctcttc atgctggctg tcactgtgat gaatggtgtg atcaatcgga 586921 aggaaatgcg tggaaggaag gttattcatc cattttacat atacgttttc atttctttta 586981 acctcaatgg tcggtcccgg aaataagccg ttgtagcccc acaggcgggt tggagggaga 587041 tcgcgatgga gctgatgagt gcattcctcc atggtgactt cgtagtatgt tttttctttt 587101 gattgctgta ctggctttag tgtatctggg attgggagag catccacaaa tttttcaagt 587161 gtcattttca tctgtcctta tctaaatttt ccaaattggt actatagtta atgacaataa 587221 ggacgtgatg gttacaaaaa atcttcgtgc tgcagcccgc ccgaagaaga aaataacaaa 587281 atcctaaacg gcaggccgtt taggatttga tcagcattaa ggcaggatat cgggttgctg 587341 ctgtgtgact gggttggcag ccgctttctc gctcaccttg cgttttctga acacaaggta 587401 agaaatcaga acgattcccg tgatgacgcc tgtcagcagc agctcgtctc tcatggaatc 587461 aataaacgcc atggacacta aaattccgca aatggcgatg atggtcaagt aggttaggaa 587521 agggaagagc cacattttga tcttcaatgc ttctgggttt gttttttcga gttttttccg 587581 cattttcagc tgggaaacgg cgatgacaag atagacgagt aaagcgattg cgcctgatga 587641 gttgactaag aataaaaaga cggtatccgg tgaaaaatag ttcattacga ccgcgatata 587701 agagaaaaat gtcccggcca caatggcttg tacgggaacg ccttttttgc tcaatttcat 587761 aaaacggcgc ggcgcttcat ttctttctgc aagtgaatac agcattctgg atgtggtata 587821 caaacctgaa ttcaggcaag agagtacggc tgtgaggacg ataaagttca taatctgtgc 587881 ggctgcgggc actcctatat gctcaagtac agcgacgaaa gggctttcta aaatatttgc 587941 tgaattccat ggcaacagcg ccacgacaat ggcgattgag cccacgtaaa agacgatgat 588001 gcgccataca acggatctgg tggcttttgt cacagattcg atcgggttgg atgtttcccc 588061 tgctgcaatg gcaacgattt cagttcccat aaaagagaag atgacaacga caatgccgag 588121 caatacggag ctgatgccct ccgggaaaaa tccgcctttg cctgtaagat tcgaaaaacc 588181 gactggctca ctgcccggtg caaagccaaa aataaaggca aaaccaacga ttagaaaagc 588241 aatgatagtc acaactttaa tgagggagaa ccaatattca aactcaccga aagacttaac 588301 ggagtagacg tttgtcaggg tgagcacaat ggtcaagatc aaacttgtca gccacagcgg 588361 aatatcatgg aaccagtatt gaataatgcc agcaccggca atggcttcga tcgctatgac 588421 gatcacccag aaaaaccagt acagccagcc gattgtaaat cctgcccacg gtccgatggc 588481 gtcgtgagcg tattgagaaa acgatccgct cgtcgggttt acggcagaca tctcaccgag 588541 cattctcata ataaaaatca ccaataatcc ggctaacgcg taagaaacaa cggcacccgg 588601 accggtcgag tgaatcactg aaccgctgcc tacaaatagg ccggctccga ttacaccggc 588661 aatcgaaatc attgtcatat ggcgggtctt taattccttt tttaatcctg attgagactg 588721 gttcataagt tacctccttt taaaatgcaa tcattactga atattatgat aattgaaact 588781 ctatcataaa tatacagttt gtcgaaaatt cgtgtaagaa aatataccag cttatttcaa 588841 atttgtagtg ttttgtttgc gctttcagcg aatgtgtgga aaaaatgttt cgttttttat 588901 tcgctgtgtg attttgcgta atatttacaa ttcgatagaa tgcgagaagc actggtgtcc 588961 ttgggtttga tgggattttt ggcggagcaa ataaattgga tgagagaaaa agtgttcctt 589021 cgtcactatt tttctgtggc gggtgaatca tgtttctgta gacccactgc ggatcagctt 589081 tgtaagataa taataggaaa atgtgagcga gaggaggttt tgtatggaga gatatgatga 589141 actgaaaaag ggagaatccg gagcgctggt cagcattgcc gcgtatctag ttctttccgc 589201 aattaaactg atcatcggtt atctttttca ctcggaagca cttacggcag acgggttaaa 589261 taacacaact gacattattg cttctgttgc tgtgctgatt ggcctgcgca tctctcaaaa 589321 gcctcctgac gaagatcatc catacggcca ctttcgagcg gaaacgattg catcgcttat 589381 cgcatcgttt attatgatgg ttgtcggact gcaagtgctg ttcagcgccg gagaatctat 589441 tttttctgct aaacaagaga cgccagatat gattgcggct tggacggcag cgggcggggc 589501 agtcctgatg ctgatcgttt accggtacaa taaaaggctg gccaaaaagg tgaagagcca 589561 ggcgctcctt gctgcggctg ctgataataa atcagacgca ttcgtcagta tcggcacatt 589621 tatcggcatt gtggctgctc aattccatct tgcttggatt gatacggtca ctgcgtttgt 589681 gatcggtctg cttatttgca agaccgcatg ggatatcttt aaagagtcat ctcactcttt 589741 gacagatgga ttcgacataa aggacatttc cgcttataaa cagacaatcg aaaaaatctc 589801 cggtgtgagc cgtttaaaag acataaaagc aagatacttg ggcagtacgg ttcatgttga 589861 tgtggtggtt gaggtatcgg cagatttaaa tattacggaa agccacgata tagccaatga 589921 aattgagcgg agaatgaagg aggagcatgc gattgattat tcgcatgttc atatggagcc 589981 tttagaacaa aaataatgga gcttcctgtc acaggaagct tcagcgtgtc gacaaaccct 590041 cgcattcgtt gtcaggtctg cgcttcggtg ctcacgaatt agaacattcg ctccgctcct 590101 atgctcgtcc ttcctagact tcaagggttt tcaatcacgc tgaaaagatg acaaaaccct 590161 aaaatgaaag ccattttagg attttgtcaa caatctggag cttcctgcca caggaagctt 590221 ttttgtgtgt tttggccagc tttattggta acaatttgct agaatcgttt ttttatacag 590281 attgcttttt gtggtaaagt taggttacat tatgatgaat tttgtagatg actaggagga 590341 aaataatggc atatcaagaa gacctgcatc ctttgctggg gaaagcagtt gaacatatta 590401 atagagtaat ggttggaaaa cgagacatcg ccatactcag cttagcagcc cttcttgcca 590461 aagggcatgt gctgcttgag gatgtacccg gagtcggaaa aacgatgatg gtccgcgcgc 590521 tggcaaagtc aatcggcgcc gatttcaaaa gaatccaatt cactccggat ttgctgccat 590581 ctgatgtaac aggggtatct atctataatg cgaaaacgat ggaatttgaa tatcgtcccg 590641 gcccaattat gggaaatatc gtgctggcag atgaaatcaa ccgtacctct ccgaagacac 590701 agtcggcttt gctcgaagcg atggaagagg ggagcgtcac ggtagatggc catacgatgc 590761 agcttgccga tccgtttttt gtgatggcaa cgcaaaaccc ggtcgaatat gaagggacct 590821 atcctttgcc ggaagctcag cttgaccgtt ttttattcaa acttcggatg ggttatccgt 590881 cctttaatga agagcttgac gtcttatctc ttcaggaaaa aagccatccg attgagacgc 590941 ttgagccggt tattgcaaaa gaagacttca tctttttaca gagggaagtg caaaatgtcc 591001 gtgctgatga cagcattaag gaatatatcg ttgaaattgt gcagaaaacg agacagcatc 591061 cttctgttca attaggcgtc agtccgcgcg gctcaatcgc cctcatgaaa gcggcacagg 591121 catacgcgct gctgcatcat cgcgactatg tcataccgga tgatattcaa tatttagctc 591181 ctttcacgct gccgcaccgg atgatgcttc atcctgaggc aaaatttgaa gggattcagg 591241 cagaagcgat cgtaagggag atcatgtcag ctgtgaaggt gccggttcaa aggtcggcgg 591301 tccgctgatg aataagaaat ggcaatggct cgtatatggt tggaagctga ttatattaac 591361 tttattgacg gctgctgttt tttcttatgc gatgtttcag ggcggctttg tcagctggtt 591421 tttgttttac gcgtttctcc cttttgtctt gtatgccggg ctgttggcct tgtatccgct 591481 ccgttctttt caggcttcaa ggcaaatgga taaaacacaa ttgcatgcgg gggacaggct 591541 gggcgtaacg gttacgctga gaagaaagct gccatttccg ctgatgtata tggtgattga 591601 agattgcctg ccagaaggta tcgagtcatt aaatcgagac ggagccgcgg ccaaacggct 591661 cgtttttcct tggtttaaac ggagcatgac gatgtcgtat gaattagctc gggtaccgcg 591721 cggagagcat cactttcatt ctgtcagggt gcgaaccggg gatgttcttg gcttgattga 591781 aaaaacagca ttttttgagc tggatgatac cttgtttgtt tatccattct atcagcgttt 591841 ttcctatcag gtgaatgaga ggcatcagga agacggtgta agcggttctt ctcctattca 591901 tcagcaccat tcctcagtcg cagcaagtgt gcggaattat cagccgggag accggtttgc 591961 tgcgttagat tggaagacat ctgcacggcg gagccagctg atgacgaagg aatttgagcc 592021 ttctcgcagc aaaaatctgt ttctgctgat ggaccgtttt tcctcagacg cattcgaaga 592081 ggtcgtttca gtgacagctt cgattcttca ttctgtttta aaaaacggcg cgggtgctgg 592141 tctggcttcc atcgggaagg aaaaaaacat tttccctatt caggaagggg atcagcattt 592201 taagcacatg cttcggcatt tagccatcgc tcattgtgat gcggcagacc cgataagccg 592261 atatgcacgg gaagagctgg gaaagccatc tgttcgccaa gctgatcaag ttgttgtcac 592321 gggacagtta acggaagata tgctgcacct cgcagaaata ggaggcggcc gggttacggt 592381 gatactggca aaagagaaag atgctgagct ctctcaagct gaaaatgtca tgattgaacg 592441 catgatgaaa cgccaaatca gagttcggat catgaggggc gggcgagttt cgcgtgttgt 592501 ttagaaagag aggtgactgg ttcacatgcc gcacgatgat cacaagggaa gccgtttgag 592561 cttgctgtta ttttattttc tggctttttt attgctgtgg gagtggctta ggccgcttga 592621 cagttttact gaaacgaaac atacaggctt ttttagtgtc tttatcggct tgacgtttct 592681 gctgactttt ttcaggatga ggtggtttgt caccgttcct ttttgtgtca tatttacatt 592741 gatctcgata cacatcctgt tttatcaagg atctatattc gacttgagct gggtcagctc 592801 ttttttgcag gatgtctatc tgaatatcac gctgattcaa tcagggcaat ggaatgacat 592861 gattccttca tttcggaccc tgctgttttt tgtgctgctg tggctgctgg tctatctcct 592921 gcattattgg gtgatttacc agagaagaat tttgtttttc tttttgatga cagtagcgta 592981 tattacgatt cttgatacct ttacgccata tgatgccact tttgccgtaa tccgtatcgt 593041 gctgatcggc ttctttatgc tgggcctttt atacttggaa cgcattaagc tgatggaaag 593101 aatcacactg ccaaaaacat ctgtcctgaa atggtttctt cctttatctg tattggtttt 593161 ggctgcaacg ggattcggac tcgccgctcc aaaatcagag ccggcttggc ctgatccggt 593221 gccttttctt aaaaaaatca ctcatcaaga ccgcgtgtct gcaggggaaa gcaaaatcgg 593281 atacgggaat catgatgaat cactcggcgg cccgttccag caggatgcta cacctgtttt 593341 tacatggcag ggaaaagagc gtacgtattt ccgtgtggaa acgaaggaca cgtataccgg 593401 aaaaggctgg attgaaacag acacaggcat gtcgtatcag cttagcaatg gaaaagttga 593461 aaatctgtgg tttgaccata aggttgcgac agagcgccgc accgtccgtg taaaagtcga 593521 taagcactac gggtataacc atctgatgta tccgattggt gcggaaacca ttcagccaaa 593581 gcaggctgtc tcacttgaaa tgaacggcaa cacggagcaa atttctccga tcagtgaaca 593641 agccggtgaa atcagaaata tggggaatta tacagtaacg tacaattccc cggtctataa 593701 gctggatgaa ctgagaaagg taaaagtgag aaaaaacagt gaggagtaca cattcagcga 593761 tcgctacatg cagcttccag attcactgcc agagcgggtg agaacccttg cgatcaaact 593821 gactcaggat cacgacaata tgtttgataa ggtgaaagcg gttgaggact atttagggtc 593881 aaatgcgttc acatatgaaa cagaaaacgt gaccattccg aagaatgatg aagattatgt 593941 cgatcaattt ctctttgaaa cgaaaatggg ttattgtgat aacttttctt ccgccatggt 594001 ggtgctcttg cgctcggccg gcattccggc ccgctgggta aagggttata cgtccggcga 594061 atacaaagaa gcagggaaca aaaatggcag catttacgaa gtgacaaata acaatgccca 594121 ttcctgggta gaggtgtatt tcccggaaca gggctgggtt acatttgagc cgactaaagg 594181 gtttacaaat ccggctcaat ttacatcttc tgacacaaaa gactctggca gcgatagcag 594241 cagctcgccg aagaaagcaa aagagaaaca gaaagaagag aaaaaacagc cgcaaaaaga 594301 ggaaaaacaa aaggaaaagc gggagccagc tgtttctaaa aagccgtccg cttcgcatac 594361 taatgccggt gcgggcttgt atgcagcgct tgcggttctt gcagtcctcc tggtggcagc 594421 tgtattgctg tatgttttcc gctcgttatg gattcctgtt ttcgccgtga ggaaattgaa 594481 gcggcgcagt gatcagcacg cgttttttga ggcatatggc gcgctgctga aacaactgaa 594541 gagaaaagga ctgccgaaac gagacagtga aacgctgcgt gattatgcaa aacgaattga 594601 tgaaaaatac gacatagaag acatgtcaaa gctgacatta agctatgaaa gggcgcttta 594661 cagaaatgaa gattcttcgg cgctatggaa tgattcgaga gagttatggg aaaatttaat 594721 taaaagaaga tggtcttgac cgcttatcga cgtgttgtta gaattagtga atattatcgg 594781 agtctgggag cgagttggcc tgactccggc aaacggcctt gccaaagagg gcggagcgag 594841 cttcatatct gtcctcgttt ttttctgtgt caaaaaactt agaggagatt aggtgacaac 594901 catgacaaag ttagtgaatg aaatgattct tgtccttgat ttcggcagtc agtataacca 594961 gctgattaca cgccgtatcc gtgaattcgg tgtttacagc gagctgcatc cacatacatt 595021 gacggctgaa gaaattaaaa aaatgaatcc aaaaggaatt attttatccg gcggtccaaa 595081 cagtgtgtat gatgaaaact ctttccgctg tgacgagaaa atcttcgagc ttgatattcc 595141 tgttttggga atttgctacg gcatgcagct gatgactcat taccttggcg gtaaagttga 595201 agcggcaagc cagcgtgaat acggaaaagc aaacatccgc atcgaaggca cacctgattt 595261 gttcagagat cttccgaatg aacaagtggt ttggatgagc cacggcgatt tggttgtaga 595321 agttcctgaa ggcttcactg ttgacgcgac aagccatcac tgcccgaact cagcaatgag 595381 caaagcggac aaaaaatggt atggcgttca gttccacccg gaagtgcgcc actctgaata 595441 cggcaatgat cttctgaaaa actttgtatt cggtgtttgc gaatgcgaag gcgaatggtc 595501 aatggagaac tttatcgaaa tcgaaatgca aaaaatccgt gaaacggtcg gagacaaaca 595561 ggttctttgc gcgctaagcg gcggcgttga ttcctctgtt gttgctgttt tgattcataa 595621 agcgatcggc gaccagctga cttgtatctt tgtagaccat ggtcttctcc gtaaaggcga 595681 agctgagggt gttatgaaaa cattcagcga aggctttaac atgaatgtga ttaaagtaga 595741 cgcaaaagat cgattcttaa acaaactaaa aggcgtttct gatcctgagc aaaaacgcaa 595801 aatcatcggt aatgaattca tttacgtgtt tgatgatgaa gcggacaagc tcaaaggcat 595861 cgactacctt gcacaaggta cgctttacac agatatcatc gagagcggta cagcaacggc 595921 gcaaacgatc aaatctcacc acaatgtcgg cggacttcct gaagacatgc agtttgagct 595981 gatcgagccg ttaaatacgc tcttcaaaga cgaagtgcgc gcgcttggca cagagctcgg 596041 cattccggat gaaatcgtat ggcgtcagcc gttcccagga ccgggactcg gaatccgcgt 596101 tcttggcgaa gtaacagaag aaaaacttga aatcgttcgt gaatcagatg caatcttgcg 596161 tgaagaaatt gcaaatcacg gcttagagcg tgatatctgg caatacttca ctgttcttcc 596221 tgacatccgc agcgttggtg ttatgggtga cgcaagaaca tatgattaca caatcggaat 596281 ccgcgccgtt acatcaatcg acggcatgac atctgactgg gcgcgtatcc cgtgggatgt 596341 gcttgaagtc atttcgacac gtatcgtaaa cgaagtgaag cacattaacc gcgtggtgta 596401 tgatattaca agtaagccgc ctgcgacgat tgagtgggaa taagaatcaa ttaatggaaa 596461 ccatcttttt ggcaattttg ccgggaagat ggttttattt gtttattacg aacaaaatcc 596521 gattttgcgc gactattgtt cgctttttgt attgtttttt caaaatgaac ttggtacaat 596581 agacacagaa atcaaataag atgaattcgt ataatcgcgg gaatatggct cgcaagtctc 596641 taccaagcta ccgtaaatgg cttgactacg taaacatttc tttcgtttga tataaataaa 596701 acacggttat ttattcaaac tgaaatccgt ctgtagtcaa gcgtcccaaa atgtattggg 596761 acgtttttta tttggcgttt tcaggacaga ataaatagca aagagtgaag ggagtcaaat 596821 agcttgaaaa cgttttttca gtttgatgag ctgggcacca gctatcgcaa tgaaatcatt 596881 ggcggattaa cgactttttt atctatggca tatattttgt tcgtcaatcc gattacgctt 596941 gctttggaga gcgtgaaaga ttttccggag gcgctgagaa ttgaccaggg tgcggtcttt 597001 acggcgacag cgctggcgtc tgcagcaggc tgtatcttaa tgggattaat agcgagatat 597061 ccgattgcca tcgcgccggg tatggggctg aacgcgtttt ttgcgttttc tgttgtcctt 597121 ggtatgggta tttcatggca ggcagctttg tccggtgttt ttatttcagg tcttattttc 597181 gttgctcttt ctttaacagg ttttcgtgaa aaaatcatca acgccattcc gcctgagctg 597241 aaattggcag tcggtgcggg gatcggcctg tttattacat ttgttggatt acaaggttca 597301 ggaatcatta cagcgaatcc ttctacgctc gtcacgatcg gaaacattca cagcggtcct 597361 gtgctgttaa cgattttcgg tgtgattgtc acggttattt taatggtgct tcgcgtgaac 597421 gcaggcgtgt ttatcgggat gctattaaca gcggtagccg gcatgatttt cggtttggtt 597481 ccggttccga ctcaaattat cggcagtgtg ccaagccttg cgccgacttt cggacaagcg 597541 tggattcacc tcccggatat tttctctgta caaatgctga tcgttatttt aacattcttg 597601 tttgtcggat tttttgatac agctggtaca cttgttgctg tggcaacaca agctggttta 597661 atgaaggaaa acaaattgcc gcgtgcgggc cgtgcgcttt tagctgattc atcttctatt 597721 gtgatcggtg ccgtgcttgg tacgtctaca acaacttctt acgtggaatc aagctcaggt 597781 gtcgctgcgg gtgcccggtc aggatttgcc gcaattgtaa cagggattct ctttttactg 597841 gctacgtttt tctcgccgct cctatcagtc gttacgtcaa atgtaacagc gccggcgctt 597901 attattgttg gtgcattgat ggtggcgccg cttggcaaaa tcgcttggga taagttcgaa 597961 gtggccgttc ctgctttcct taccatgatc atgatgccgt taacgtacag catcgcgact 598021 ggtattgcca tcggatttat tttctatccg attacaatgg tgtgcaaagg aaaagcaaaa 598081 gaggttcatc caatcatgta cgggctgttt gtcgtattta tcctgtactt tatcttctta 598141 aaataaggaa tgaaaaacca gctgcactgg cagctggttt ttttgttgca aaagataaaa 598201 ccatttcata cgatataccg tcatgtagat gtgccgccat gctttactta aatggaaatg 598261 acttgactgt tcaggaaggc ttcggtacct tatataagtg ttttattttc ttgctgaatg 598321 gtattccgcc gtattttttt gataggagtt gctgacatga cggaagaaag aaaagaaacg 598381 tttgaagaag aaattaacca gagtgaaaga atagatgcag atgaagaacc gctatcgaga 598441 atgtccagaa aggcgagccg gcaaagcaag cagaagcaaa aacaaaagca gaaaccgcgc 598501 caggaacgcg gtgaatcaac tgttaaagac aagcttgcgt ctgtttgggc agccatcaac 598561 agatattgcg gttttgcgtt ctcgatttta aaatctccgg cgaaaactgt cgtaacggat 598621 ggtttttctc attataagta cggtctgatt tcaatgctta tattcagtat cattttttca 598681 attgggaatt ggtttcagtt aaaggcaagc tggaatcggc cgctcggttt cggagaacgc 598741 catcatgctt tctatgacgg gtttttagtt gttcttgtgt atttgctgat ctttttcgcg 598801 gtaatggtct ttgctatatg ggctgtctcc cgctatatga tgaagcagaa ggtgacgttc 598861 agagaagcgg ctgccgtatt gggttcattg cttgtacccg taattgctgt ttcaatcctt 598921 tggctgatct ttgcgatcgt aaatatccca atgctgacag tactgtttac ggtgctgatc 598981 ttgttttcca tcttttttat catcgcgctg tatgtacagc gtgtgtacca ggcggcacaa 599041 gatgcaccaa ttgattatat ctattgtgta tttgcagtag ttgcgatagc gctgctgttt 599101 acggcagtga cttggccgtt tatttctgaa tatattacgg cgtcgttgat tccgctttaa 599161 tgaaaaaacc ggctaatcct agccggtttt tttatgtcac actttttaca aatatatcta 599221 aaaaacatag ttgatttgta ggattaaccc gtgtatgatg gggaaaatgc tgaaaacgtc 599281 cagcgcaaaa acctttatgt ttaaggagga tgatggacat ggctgatgta cttcgccgag 599341 caattaacca aaagaagcaa tttttaaaaa ccaaattact gctctcggaa ttttatcaag 599401 gaagagggga acagcttgct gactacacgc tgagtgagct tgagaaagaa tacaagtccc 599461 ttcagaaaat gaaaaaagag atctgacaat agatataaag aggtgagtct gctgaaaagc 599521 gggctttttt gttttgattt tgaaaaggcg agaaagaggg taaactacta ctgttcaaca 599581 cataaaagcg tgtcgaaata ttttgcttaa gcttacgggc gaagctgatt gtaaacggct 599641 catttctcta gtagaatatg aatgctttgt gcaagctgaa gagtaggggg atgaataaaa 599701 tgatgcaaac catcttatca aatgggatag ccatggttct cataattctc attattaata 599761 ttgtctatgt gtcatttttt acgataagaa tgattttaac gctgaaagga cagcgttatt 599821 tagcggccgg catcagtacg attgaaatac tggtttatgt gacaggactg agtctggtgc 599881 tcgataactt agaccagatt caaaatgtga tcgcgtacgc gctcggttac ggtcttggcg 599941 taattgtcgg catgaaaata gaagaaaaat tggcgcttgg ctatattatg gtcaatgtga 600001 ttacgaagga gctcgatctt gatcttccga agcagctccg tgaaaaaggc tacggcgtga 600061 caaactgggt ggcaggcggg cttgaaggcg accgcacagc ccttcagatc ctgacgccga 600121 gaagatatga actccagcta tatgatacga ttaaaacact tgattcaaaa gcctttatta 600181 ttgcgtacga accaaaaaca atccacggcg gcttctgggt caaagcggtg aagaagagga 600241 gaattaaaga ataatggcaa agccgaagaa gaaaaagttt gaagtgacag agcagcaaac 600301 gattgatgcg gtgcttcagc aaatgaaaga agaaggatat ctgcctgtaa ggcgaatgga 600361 agagcctatt tttatggaaa aaaaggaaaa tgggtcaatt cagatcgttc cgtgcgggaa 600421 aaaaatcgta tttgaaggga aattgatcta aaacacgaac attagtagaa tgaatttttg 600481 tatcgttcga taatatcgtt gacattatcc atgtccgttg ttaagataaa catgaaatca 600541 aaacacgacc tcatataatc ttgggaatat ggcccataag tttctacccg gcaaccgtaa 600601 attgccggac tatgcaggaa agtgatcgat aaaactgaca tggatatatc gcagaagcga 600661 acgactgacg atacatgtac catgcccggt ttgtattgct tcctcataag tgcaatgcag 600721 agcgggtatt ttttattttc tgaaaacaaa agcattagaa ggtggggaac agaatgcagc 600781 cgctagtagg aatcatcatg ggaagcactt ccgattggga gacaatgaaa cacgcatgcg 600841 acatacttga cgaactcaat gttccgtacg aaaaaaaggt cgtttccgct caccggacgc 600901 ctgatttcat gtttgaatat gctgaaactg ctagagaaag aggcatcaag gtgattattg 600961 ccggtgccgg aggagcggcg catctgccag ggatgacggc tgcgaaaaca acactgccag 601021 tcattggagt tccggttcag tccaaggcgc tgaacggaat ggattcactt ctttccatcg 601081 tccaaatgcc tggaggcgtg cctgttgcga caacatccat cggcaaagcg ggtgctgtga 601141 acgcaggcct gttagcggcg caaattttgt cagcatttga cgaagacctt gcccgtaagc 601201 tggatgagag aagagaaaat acaaaacaga cagtgttaga aagcagtgat cagcttgtct 601261 aaacaaatca tctatccggg agctgtaatc ggcattatcg gcggcggcca gcttgggaaa 601321 atgatggctg tgtccgccaa acaaatgggg tataaagtcg cggtcgttga tccggtgaaa 601381 gattcgccgt gcgggcaggt tgcggatgtc gaaattaccg ctcattataa tgaccgtgaa 601441 gcgattcgaa aattggctga aatcagcgat atcatcacat atgagtttga aaacatcgac 601501 tatgatgcgc tgcattggct aaaagatcat gcgtatctcc cgcaaggaag tgagctgctg 601561 cttattaccc aaaaccgtga aacagagaaa aaagcaattc aatccgcggg ctgtgaagtc 601621 gcaccgtaca gcatcgtcaa aacaaagaat gaattgaaac aggcagtaca ggagctcagg 601681 cttccggcag tgctgaaaac atgccgcggc gggtacgacg gcaaaggcca atttgtgata 601741 aaagaagagg cgcaaatgga gcaggcagcc gctctgttag aacacggaac ttgcattctt 601801 gaaagctggg tttcttttaa aatggaactg tcggtgatcg tcgttagatc ggtaaacggt 601861 gaaatttcaa catttccgac agctgaaaac attcaccaca acaatattct tttccaaagc 601921 atcgtgcccg cacgggtaga gaaagggatt cagcagaagg ctgctgatct cgcagttaag 601981 cttgcagatg agcttaacct tgtcggaccg cttgctgttg agatgttcct gacagaggac 602041 ggagagcttt tggtcaatga actggcgcca agaccgcaca attcagggca ttatacgctg 602101 gacctttgcg agacgagcca gtttgagcag catatcagag cggtatgcgg gcttccgctt 602161 gggaagacag atttgctgaa gccgggcatg atggtgaatc ttctcggcga tgaagtgaag 602221 cttgttgagg aagacccgga gcttttaaaa gaggcaaagc tatatatata cggaaaacat 602281 gaaatcaaaa aaggccgcaa aatggggcat attacattta tgaagcagcc tgaagacgaa 602341 tggattcagg agatcacaaa taaatggatg aatagagacg gaggacaagc agaatgatcg 602401 aacgttattc aagacctgaa atgtccgcga tttggacgga tgaaaacaga tttcaagcat 602461 ggttagaggt tgaaattctt gcctgtgaag cgtgggcgga gcttggcgtc attccgaaag 602521 aagatgtaaa ggttatgcgc gaaaacgcgt catttgacat caaccgcatt ttagaaatcg 602581 aaaaggacac gcgccatgac gttgtcgctt ttacgcgcgc tgtatccgaa tcactgggcg 602641 aagaaagaaa atgggtgcat tacggcttaa cgtcaactga cgttgttgat acggctcttt 602701 cctacttatt aaaacaggca aacgatattt tgctcaagga tcttgagaga tttgttgaca 602761 ttataaaaga aaaagcgaaa gaacataaat acacagtcat gatggggcgc acacacggcg 602821 tacacgctga gcctacaaca ttcggcttaa aacttgcgct ttggcatgaa gaaatgaaac 602881 gtaatcttga gcgcttcaaa caagcgaaag caggcatcga ggttggaaag atttccggtg 602941 ctgtcggcac atatgcgaac attgatccat ttgttgaaca atatgtctgt gagaagctcg 603001 gattgaaagc agcaccgatt tccactcaaa cccttcagcg tgaccgccat gctgactata 603061 tggcaacact tgctttgatc gcgacaagca tcgagaaatt cgctgtggaa atccgcggac 603121 tgcaaaagag tgaaacacgt gaagtagagg aatttttcgc gaaagggcaa aagggttcat 603181 ctgcaatgcc gcataaacga aatccgattg gctctgaaaa catgacaggc atggcgcgcg 603241 tgatccgcgg ctacatgatg acagcttacg aaaatgttcc attatggcat gagcgcgata 603301 tttctcattc ttcagcagaa cgaattattc ttccggatgc gacaattgcg ctgaactaca 603361 tgctgaaccg cttctccaac atcgtgaaga acttaacggt cttcccggaa aacatgaagc 603421 gcaacatgga ccgcactctc ggccttatct attctcagcg tgtgctcctt gctttgattg 603481 acacaggcct gactcgtgaa gaagcctatg atacagttca gccgaaagca atggaagcgt 603541 gggaaaaaca agtgccgttc cgcgagcttg tggaagcgga agagaaaatc acgtcacgtc 603601 tttctccaga aaaaattgct gactgctttg attacaatta ccatctgaaa aatgttgatc 603661 tgatctttga acgtttaggt ttagcataga agaagctttt agcggcttct tctaagccgc 603721 cgcagtttga aaattcccaa cattcgggtt aggaggcctt ccgtgaatat tgtgaagaat 603781 gaacttttat acgaaggaaa agcaaaaaag atctacaaaa ccgatgacga aaacacgctg 603841 tatgtcgtgt ataaagactc cgccactgcc tttaacggcg agaaaaaagc agaaatcagc 603901 ggaaaagggc gcttaaataa tgaaatttca agcctcattt tcaaacacct tcatgctaag 603961 ggcattaaca atcattttat cgagcgcatt tcggaaacgg agcagctcat taaaaaggta 604021 acgattgtgc cgcttgaagt cgtggtaaga aatgttgtgg caggaagcat gtccaaacgt 604081 ctcggcattc cagaaggcac ggagcttgag cagccgatta tcgagtttta ctacaaggat 604141 gacgcgctgg gtgatccgct catcacagaa gatcatattt ggcttttgaa ggcggcgact 604201 cctgagcagg tagaaaccat taagtccatt acaacaatag taaatgaaga gcttcaaagc 604261 atcttcgacg attgtcatgt cagattaata gatttcaagc ttgaattcgg tttagatgca 604321 gaagggcaag tgcttttggc ggatgaaata tctcctgaca catgccgctt gtgggataaa 604381 gaaacgaacg aaaagctgga caaagattta ttcagacgca atctgggaag cttaaccgac 604441 gcatacgaag agattttcaa tagactggga ggcattcatc atgtataaag taaaagttta 604501 tgtcagctta aaagaaagtg tactagatcc acaagggagc gctgtccagc atgccttgca 604561 cagtatgact tacaacgaag ttcaagatgt gcgcatcggg aaatacatgg agcttaccat 604621 tgaaaaatct gaccgtgatc ttgacgtgct agtgaaagaa atgtgcgaaa aacttcttgc 604681 gaacacagtg attgaagatt atagatatga ggttgaggag gtagtcgcac agtgaaattt 604741 gcggtgattg tgttacccgg ctccaactgt gatatcgata tgtatcatgc tgtaaaggat 604801 gagctcggcc atgaagtgga atacgtctgg catgaggaaa caagccttga cggcttcgac 604861 ggcgtgttaa ttccgggagg attttcttac ggcgattact taagatgcgg cgccatcgcc 604921 cgatttgcga atattatgcc agctgtcaaa caagcagcgg ctgaaggaaa acctgttctt 604981 ggcgtctgta acggattcca gattttacag gagcttgggc tgctgccagg cgcaatgaga 605041 cgcaacaaag atctgaagtt catttgccgt ccggttgaat tgattgttca gaacgacgaa 605101 accttattca cagcttccta cgaaaaggga gaatcgatta caatcccggt tgcccatggt 605161 gaagggaatt tctactgtga tgacgagacg cttgctacat taaaggaaaa caatcaaatt 605221 gctttcacat acggctctaa tattaatgga agtgtcagcg acattgccgg tgtcgtgaat 605281 gagaaaggca atgtattagg catgatgcct caccctgagc gcgcggtcga tgaactgctt 605341 ggaagcgccg acggtcttaa attgttccag tctatcgtga aaaattggag ggaaactcat 605401 gtcactactg cttgaaccaa gtaaagaaca aataaaagaa gagaaactgt atcagcaaat 605461 gggtgtcagt gatgatgagt ttgcattgat agaatccatt cttggaagat tgccgaacta 605521 cacagaaatc ggaatttttt ctgtcatgtg gtctgagcat tgcagctata aaaactcaaa 605581 gccgattctg cgtaaattcc cgacaagcgg cgagcgtgtg ctgcaggggc cgggggaagg 605641 cgccggaatc gttgatatcg gtgataacca agcggttgtg ttcaaaattg aatcacataa 605701 ccacccatca gctctcgagc cttaccaagg cgctgcgact ggcgtaggcg gaattatccg 605761 tgatgtattc tcaatgggtg cacgcccaat cgctgtattg aactctcttc gatttggtga 605821 actgacttca ccccgcgtga agtacttgtt tgaagaagta gtagcgggta tcgccggata 605881 cggcaactgt atcggcatcc cgacagtcgg cggagaagtg cagtttgaca gcagctatga 605941 aggaaatccg ctcgtcaacg caatgtgcgt cggtttaatc aaccatgaag acatcaaaaa 606001 aggccaggca aagggtgtcg gcaacacagt aatgtacgta ggagcgaaaa cagggcgtga 606061 cggcatccac ggcgctacgt ttgcttctga agaaatgtca gactcgtctg aagaaaagcg 606121 ttctgctgtc caagtcggcg atccgtttat ggagaagctt ttgcttgaag catgtctgga 606181 agtcatccaa tgcgacgcct tagtcggcat tcaggatatg ggagctgccg gtttaacaag 606241 ctcaagtgca gaaatggcaa gtaaagccgg ttctggcatt gaaatgaatc ttgacctgat 606301 tcctcagcgc gaaacaggca tgaccgcgta tgaaatgatg ctttctgaat cacaagaacg 606361 gatgcttttg gttattgagc gcggacgtga gcaggaaatc atcgatattt ttgacaagta 606421 tgatcttgaa gcggtttctg tcggacatgt gacagatgat aaaatgcttc gcctgacaca 606481 taaaggagag gttgtgtgcg agctgcctgt tgatgccttg gcagaagaag caccggttta 606541 ccataagcct tctcaagagc ctgcttacta tcgcgagttt ttggaaacag acgttccggc 606601 tccgcaaatt gaagatgcga atgaaatgct gaaggccctt cttcagcagc cgacgattgc 606661 gagtaaagag tgggtttatg atcagtatga ctacatggtg cgcacgaata cagttgtcgc 606721 tcctgggtct gatgctggtg ttctcagaat ccgcggaacg aaaaaggcgc tggcgatgac 606781 gacagactgt aacgcgcgtt atctctatct tgatcctgaa gtcggaggga aaattgctgt 606841 cgctgaagca gcgcgcaaca tcatttgctc aggcgcagaa ccgcttgcgg tgacagataa 606901 ccttaacttc ggaaaccctg agaagccgga aatcttctgg cagatcgaaa aagcggcaga 606961 cggcataagc gaagcgtgca atgttctcag cactccggtt atcggcggta acgtatcgct 607021 ttataacgaa tcaaacggca cggcgatcta tccgacacca gttatcggca tggtcggcct 607081 aattgaagat acagcgcaca ttacaacaca gcatttcaaa caagcaggag atctcgtata 607141 cgtgatcggc gaaacaaaac cagagtttgc cggaagcgag ctgcaaaaaa tgacagaagg 607201 ccgtatttac ggcaaagcgc cgcaaatcga tcttgatgta gagctgtctc gtcaaaaagc 607261 actgcttgac gcgattaaaa aaggcttcgt tcaatctgcg catgatgtgt ctgaaggcgg 607321 cttaggcgta gcgattgcgg aaagtgtcat gacgacggaa aaccttggcg ctaatgtgac 607381 tgtagaaggg gaagcggcgt tattattctc tgaatctcaa tctcgcttcg tcgtttcagt 607441 gaaaaaagaa catcaagctg cgtttgaagc aactgtcaaa gatgcagttc atattggtga 607501 ggtaacagct gacggaattc tggcgattca aaaccaagac ggacaacaaa tgattcatgc 607561 gcaaacgaaa gagcttgaac gcgtatggaa aggagctatc ccatgcttgc tgaaatcaaa 607621 ggcttaaatg aagaatgcgg cgtttttggg atttggggac atgaagaagc cccgcaaatc 607681 acgtattacg gtctccacag ccttcagcac cgaggacagg agggtgctgg catcgtagcg 607741 actgacggtg aaaagctgac ggctcacaaa ggccaaggtc tgatcactga agtatttcaa 607801 aacggcgaac tcagcaaagt aaagggaaaa ggcgctatcg ggcacgttcg gtacgcaacg 607861 gctggaggcg gcggatacga aaatgttcag ccgctcctct tccgttccca aaacaacggc 607921 agcctggcgc ttgctcataa cggaaatctt gtcaacgcca ctcagctgaa gcagcagctc 607981 gaaaatcaag ggagcatctt tcaaacctct tcggatacag aggttttggc tcacctgatc 608041 aaaagaagcg gacacttcac gctgaaggat caaattaaaa actcgctttc tatgctgaaa 608101 ggcgcctacg cgttcctgat catgaccgaa acagaaatga ttgtcgcact tgatccaaac 608161 gggctgagac cgctatccat cggcatgatg ggcgacgctt atgtggtcgc atcagaaaca 608221 tgcgcatttg acgtcgtcgg cgcaacgtac cttcgcgagg tagagccggg agaaatgctg 608281 atcattaatg atgaaggcat gaaatcagag cgtttttcca tgaatatcaa tcgttccatt 608341 tgcagcatgg agtacattta tttctccaga ccagacagca atattgacgg tattaatgtg 608401 cacagtgccc gtaaaaacct tgggaaaatg ctggctcagg aatccgcagt tgaagctgac 608461 gtcgtaaccg gggttccgga ttccagtatt tcagcggcga tcggctatgc agaggcaaca 608521 ggcattccgt atgagcttgg cttaatcaaa aaccgttatg ttggcagaac gtttattcag 608581 ccgtcccagg ctctgcgtga gcaaggcgtc agaatgaagc tgtctgcggt gcgcggggtt 608641 gtagaaggca aacgcgtcgt gatggtggat gactctatcg tgcgaggaac aactagccgc 608701 cggattgtca cgatgctaag agaagcgggt gcgacagagg tgcatgtgaa aatcagttca 608761 ccgccgatcg ctcatccgtg cttttacggc attgacactt ccacacatga agaactgatc 608821 gcgtcttcgc attctgttga agaaatccgt caggaaatcg gagccgatac cctctcattt 608881 ttgagtgtgg aagggctgct gaaaggcatc ggcagaaaat acgatgactc gaattgcgga 608941 cagtgtctcg cttgctttac aggaaaatat ccgactgaaa tttaccagga tacagtgctt 609001 cctcacgtaa aagaagcagt attaaccaaa taaaacttga aaaatgacat aaaggcagcg 609061 cagttcggct gcctttctct ttctgccctc gttcggggag atattttgaa aagcgcctta 609121 aaggagtgaa taggatgtct gaagcatata aaaacgcagg agttgacatc gaagccggat 609181 atgaagctgt aaaacgaatg aaaaaacacg tggagcgcac gaaacggctt ggcgttatgg 609241 gcagccttgg cggttttggc ggcatgtttg acctgtctga gctttcttat caaaaaccag 609301 ttctcatttc gggaacggac ggtgtcggca caaaattaaa gctcgctttt tccatggata 609361 agcatgacac gattggcgtg gatgctgttg caatgtgtgt caatgacgtg ctggcacaag 609421 gtgcagagcc gctgtttttc ctcgattatt tagcggttgg caaagcggac ccagtgaaaa 609481 ttgaacagat tgtacaaggt gttgcggaag gctgtgagca gtcaggttca gccttagtcg 609541 gcggtgaaac ggctgaaatg ccggggctct atacagctga tgaatacgat attgccggtt 609601 tctcagtcgg agtggcagaa aaggacgaaa tcgtgactgg agaaaaaatt gaagagggcc 609661 atctgttgat cggcctcagc tccagcggcc ttcacagcaa cggcttttcc cttgtcagaa 609721 aagtgcttct ggatgatgcg gagctggacc tcgatacaac atatgagccg tttgaacgcc 609781 cgcttggcga ggaattgctt gaaccgacaa ggatttacgt gaagcctgtg cttgccgcgg 609841 tcaaaagcgg aaaaatcgac ggcatggcgc acgtgacagg cggaggattt attgaaaata 609901 ttccgcgtat gcttccggaa ggcttaagtg cggaaattga tcatggctca tggccgatcc 609961 cgccgatttt ttctttcttg caagagtacg gcaagctaaa ggaagaagac atgttcaacg 610021 tctttaatat gggtatcggt tttgttttgg cagtcaaaga agagcatctg acagatgtga 610081 tcggaacgct tgaaagccat ggcgaaaaag cctatttaat cgggcgtgtg aaaaaaggtg 610141 aaggcgtcac attcggcggt gcggcacttt catgaaaaag tttgcggtat ttgcatcagg 610201 aaacggttca aacttcgaag ccatcgtcac gcgtttgaag gaggagaact gggatgcgtc 610261 agcagcgctc ctcgtttgcg acaaaccgca ggcgaaagtc atcgaacggg cggaagcatt 610321 ccacattcca tccttcgcat ttgagccgaa gtcttatgaa aacaaggctg catttgaaca 610381 agccatcatt gaacagcttc gtcttcacga ggttgaattg attgctcttg ccggctatat 610441 gaggctgatc ggtgatacgc tccttcaagc atatggggga aaaatcatta acattcaccc 610501 atcgcttctt ccggcgtttc ctggaatcga cgcagtcgga caggcgttcc gggcgggtgt 610561 gaaggtggcc ggaatcaccg tgcattatgt cgatgaagga atggatacag gtccgatcat 610621 cgctcaaaag gcaatcgaaa ttgatgaaca tgatacattg gaaacaatcg aacagcgaat 610681 tcacaagctt gagcataaat ggtatccgag tgtgattaaa cagctattag gattaaataa 610741 cagaggtgaa aaggcatgac cattaaacgt gcattaatca gtgtttcaga taaaacaaat 610801 ctcgttcctt tcgtaaaaga actgacagag cttggcgttg aagtcatctc cacaggcgga 610861 acgaaaaagc ttcttcaaga aaacggtgtg gatgtgatcg gaatttctga agtgacaggc 610921 tttcctgaaa ttatggacgg ccggttaaaa accctacacc cgaatattca cggcggcctt 610981 ctggcggttc gcggcaatga agagcatatg gcgcagatca atgaacacgg gattcagccg 611041 attgacctcg ttgtcgtcaa cctctatcca tttaaagaaa cgatttctaa agaagacgtc 611101 acgtatgaag aagcgatcga aaatatcgac atcggcggac ctggcatgct gcgcgcggca 611161 tcaaagaacc atcaggatgt cacggttatc gtcgatccgg ccgattacag cccagtgcta 611221 aatcaaatca aagaagaagg cagcgtatct cttcagaaaa aacgcgagct cgcggcaaaa 611281 gtattccgtc atactgcggc atatgatgca ctgatcgctg actatctgac aaatgttgtc 611341 ggtgaaaaag aaccagagca attcactgtg acatttgaga aaaaacaatc gcttcgctat 611401 ggagaaaacc cgcatcagga agcaactttc tatcaaacag ctcttcctgt caaaggctcc 611461 attgcgcaag cagaacagct tcacggaaaa gagctttctt acaacaacat taaagacgcg 611521 gatgctgcag ttcaaatcgt tcgtgaattc actgaaccgg ctgctgttgc tgtgaagcat 611581 atgaacccgt gcggcgtggg aacaggaaaa acgatcgcag aagcgtttga cagagcgttt 611641 gaagcggata aaacatctat cttcggcggc attatcgcgc tgaaccgtga agtggacaag 611701 gcaactgccg aagcgcttca caacattttc ttagaaatca tcattgcgcc ttcattcagc 611761 caagaagcgc tcgacgtcct gactgcgaag aaaaatctcc gtctgctgac gcttgacgta 611821 tccgccgctg ttcaaaagga aaaacagctg acatccgttc aaggcgggct gctgattcaa 611881 gatttagata tgcacggctt cgatgatgct gagattagca ttccgacaaa aagagagccg 611941 aacgagcaag agtgggaaga cttgaagctt gcttggaaag tcgtgaagca tgtgaaatca 612001 aatgcgattg ttctcgcgaa ggacaacatg acagtcggcg tgggagcagg ccaaatgaac 612061 cgcgtcggat cggcaaaaat cgcaatcgag caagcagggg aaaaagcgaa gggcagcgcg 612121 ctcggttcgg atgcatattt cccaatgcca gatactgtcg aagaagcggc aaaagcgggc 612181 gttacagcca tcattcagcc aggcggatcg atccgagatg aggattccat caaaaaagcg 612241 gatgaatacg gcattgccat ggtattcacc ggcatcagac acttcaaaca ttaaggggat 612301 gaaaacgacg tgaatgtatt aattatcggt aaaggcggaa gagaacatac gctggcgtgg 612361 aaggcagcgc aaagcagcct cgtcgagaat gtatttgccg ctcccggaaa tgacggcatg 612421 gcagcttccg ctcagcttgt aaacattgag gaaagcgacc acgcagggct tgtctcattt 612481 gcaaaacaaa atcaggtcgg cctgaccatt gtcggccctg aggttccttt aattgaaggt 612541 ctggtggatg aattcgaaaa agcgggctta catgtgttcg gtccgtcaaa agctgcggcg 612601 atcatcgaag gaagcaaaca gttcgctaag gatttaatga agaaatacga cattccgacc 612661 gcagaatacg agacgtttac atcctttgat gaggcgaagg catatgtgca ggaaaaaggt 612721 gctccgattg tgataaaagc agatggactt gcagctggaa aaggcgttac tgtggctatg 612781 acagaggaag aagcaattgc gtgcttgcat gactttcttg aagatgaaaa gttcggtgat 612841 gcgagcgcgt ccgttgtcat tgaagaatat ctttctggtg aagaattttc tctaatggcc 612901 tttgtcaaag gggaaaaggt gtatccgatg gtgattgccc aggatcacaa gcgggcgttt 612961 gacggagaca aaggcccgaa tacaggcggc atgggcgcct actcgccagt tccgcaaatt 613021 tcggaagaaa cggtccgcca tgctgtagaa acgatcgtta agccggctgc aaaagcaatg 613081 gtacaagaag gccgttcctt cactggcgtt ttgtacgctg gattgatgct tactgaaaac 613141 ggctcgaagg tcattgaatt taatgcccgt ttcggcgatc cggaaacaca ggtcgtgctt 613201 ccgcgcatgg aatctgatct ggtacaggtg cttcttgatc ttttagatga taaggaagtt 613261 gacttaagat ggaaggatac cgcggcagtg agtgttgtgc ttgcatcaga agggtatccg 613321 gaaagctatg caaaaggcac gccgatcggc agccttgcag cagaaactga gcaggtcgtg 613381 gtcttccatg ccggaacgaa agcagaaggt ggagagttcg ttacaaacgg ggggcgcgtc 613441 gccaatgtga cggcttttga tgaaacgttt gaagcggcta gagaccgagt gtacaaagcg 613501 gttgatgaaa ttttcaaacc gggactcttt ttcagaaaag acattggggc acgcgcttta 613561 aaggctgccc aaaaataagt gaggaaaacc cgcagaatag ctgcgggttt tttgttatca 613621 aaaagcggga tggcagctag aagaagaaag cacaacgagc gtggttggtt ttccatgggc 613681 catcgaggtg tcaataaaat cctcaagcgt atgtaccgat tcagtcacga cctttgtcac 613741 atagctgtac atccccgtga tgcggtggtt ttctgctaca tcaggatgcg atgttgcaaa 613801 ggcggcgtag tgcttgcagc ttttcggctc catgagaata aaagcggtga catgcttgtt 613861 tagtttttcg taacagatat tcgcgctgta gccggtaatc actcctttgt cttccagctt 613921 cctgacacgc tccgccgcgc ttggcgagct gagtccgaca agctttccca gctcaaccat 613981 cgttaatctg ccgtttcgct gcaaatgcga gagaatctga aggtctgtat cgtccatttg 614041 tctggctcct ttacatattt aggcgaatga atgaaaattc ctttgatcgt aaggtaatgc 614101 tgttgattta acttcattgt agcatatgga tgccgtctta ttttttctat aataaagcca 614161 tcaatcagag agggggcatc atgttgccag aattgcagcg ctctattact tggatacaag 614221 ggacggcgtt aacgattggg gcggttttag gatgcgggat attaatcctg ccgtctgtca 614281 ccgcggacac ggccggcccc gcttctttat ttgtttgggt gttcatgtcc ttcttatcct 614341 tttttcttgt cggcacgctg gcccggcttg tgaaaatagc gcctagcgcg ggaggaatca 614401 cggcttatgt gcagctggcc tttcagaaaa aagccggggc tattttgggc tggatcatgt 614461 tagggtccgt tccgatcggc gttcccatca tcgctttgac tggcgcgcat tacgtcagtt 614521 acatcacaga ggcggccgat tggcagatta cattgattgc tggttgcatg ctggctatat 614581 ctattttgct tcatatgaga gggattcaac tatcagcaaa cattagtaca ctcgttatat 614641 gtgtcatcgt atttctgctt gtcacttcta ttgctgtgtc attgccacac gtcacgatag 614701 cagaattcaa gccgtttctt ccgcatggct ggtctgccgc tggatctgtt tctgttatga 614761 tttttttctc ttttgtaggc tgggaaatga ttaccccgtt ggctgaggaa tttcatcgtc 614821 ctgaaaaaga tgtcccgctc agcttgtttt tggcagcgtc ttgtgtggcg gggctgtata 614881 tcatgctgtc atttgtgacc gtgggtactc attcatatgg agagaatgga gaaattgcat 614941 cgcttgccat gctcatttca aaaggagcag gagaaagcgg tgtatatgtc acggtatgtt 615001 tagcgctgtt tattacattc gccaccatcc atgccaatat tgccggtttt tcaagaatgg 615061 tgtacgcatt ggcgagagag gggcacatac ccgtattttt tggaaaactc agtgcgacaa 615121 aacgtacgcc tattcgcgtt ttgacagcga tggccgcagt gtttggctta gtgcttgcag 615181 cgcatggtct gtttcaaatc gatttgacga ctctgttgaa agggccgagc gcggctttta 615241 tcgcatctta catatgtaca atggcggcag cactgaaact gctgggcagg agagatatag 615301 gctggtggat ggcgctcggg gcatttgtgg cgtgcgcggt gatttattca ttcagcggct 615361 gggcactgct ttatccggca gtgctggcag ctgcaggata tttctatatg aaaacaaagg 615421 gtgggcataa aaaaaagctt gatcacgttt tgtgatcaag cttttccatt tatccgtttt 615481 gatgctcgtt atttccagaa tcgctgtgtt gaaacatgta ggtcacagga cagaagcgca 615541 agattcccga acccgctttc atggccccca taaagatgta aaagagatgc attctgcacc 615601 aaggtttttt cgtaaacttt gcactggcgg ctgacataat cgtcaatccg caggcgattc 615661 tgaacacggc attgatgaga ctgatgtttg gcttcaagga aatccgctcc ttttacttaa 615721 aaaagttttt taatcgaacc ttcaaaaatt tgtaacgttt ttatcgtgcg tgatgaggaa 615781 ggatgtgata ccatgagtct aatacatgta aaggagagta tgtgaatgtc cgaacgcacc 615841 tttaactgga aaaacaaaga catcagggca caggttgatg ttgtagactc aaagctgctt 615901 ccaacgctcc ttttacggaa tgctctcgtc ttaaatccat atgtaaaaca atggctgaaa 615961 aaaaacattt ggatttatca ggaccgcatt gtttatgtgg gtcatgaact tccgaataga 616021 gccgaagaaa ttcatacgat tgattgtgaa ggaaaataca ttgtgccagg ttatattgaa 616081 ccgcacgcac atccttttca aatatataat ccccaaacac tggcggaata tgtgtctcaa 616141 tacggaacaa cgacattcgt gaatgataac ttatttttgc ttttgcaaag cggaaaaaag 616201 aaagcgctta cgattttgaa tgaactcaaa aagcagcctg tccagtattt ttggtggtca 616261 cgctatgacc tccagaccga ggttctgaac gaggaccacg tccttccatt tgacgtcaga 616321 aaacagtgga ttgaacatcc ggatgtgatt caaggcggag aaatgaccgg atggcctcgc 616381 ctggtagatg gtgatgattt aatgctccac tgtatgcaag ctacaaagaa acagagaaaa 616441 cgtattgaag ggcattttcc cggcgcttct gataaaacgc ttacaaaaat gaagctgttc 616501 ggtgcggatt gtgatcatga agcgatgaca ggtgatgaag tgatgagaag gctggaactg 616561 ggctattatg tttcccttcg gaactcttcc attcgccccg atgtaagaaa aatcttgcaa 616621 gagctgcatg agaagggctt ccgctattat gaccacttct tttacacgac agatggcgca 616681 accccgaatt tctataaagg cggcatgaca aacgagctga ttcgcattgc gttagaagaa 616741 ggcgtacctg caatcgacgc ctacaatatg gcatcattta atatcgcaaa gtattaccaa 616801 atggatgatt atttaggagt tgtcggaccg ggcagactgg catcgctaaa catactggaa 616861 gatccgttaa atccgaatcc agtgactgtt ctgtcaaaag ggaccattct gcgtgaaaac 616921 ggctgtgatt tgaaggcgtt tacaaagacg gactggcaca aaggcggtct tgtcccgctt 616981 gagctttcat atgatatgac gatggatgac ttgcagtttt ctatgccgat gggcgtgaaa 617041 atgcggaatg cggttattat ggagccatat atgattgaga tcgacaattc gatggaacag 617101 ctctcgtttg accatgatga aagttatttg acgatgctcg acagacacgg gaaatggcgc 617161 gtcaatacga tgataaaagg gtttgcctca agcgtgcagg gatttgtaag ctcctttacg 617221 acgacgggcg acattgtcgc gattggaaaa aataaagcgg atatgctgct cgctttcgcc 617281 cgcatgaaag aaatcggagg aggaattgtt ttagcggaga acggaaacat tctgcatgaa 617341 atcccgcttg cgctgtgcgg ctgcgcctct tcggaagcgt atgaagacgt gcttgagaag 617401 gaacaaaagc tgagagatct tttgactgaa agaggctatg agttttgcga tcctatctat 617461 acgctgctct ttttgcaaag tacgcacctt ccgtatatac gcattacgcc aagaggaata 617521 ttcgacgtca tgaaaaaaac tgtactcttt ccatcgataa tgcgttaaaa tataaaagag 617581 cagggagccg acatatgaaa aaatggatga cagtttgcgc gctgtgtttc gtgttttttc 617641 tgctggtatc ctgccagcag aaggatgctg tcccggatac tgcaaagaag ctgaaagctc 617701 ctttaacggg gctaaagact gaacagaaag tgactgaacg ccgccctgtt gctgttgtgg 617761 tgaacaatca cccgaaggcg aggccgcagt cgggtctgtc taaagccgac attgtcatag 617821 aagcgctagc cgaagggcaa atcacaagat ttctggccat tttccaaagc cagatgcctg 617881 aaactgtcgg acctgtgcgg agcgcgcggg aatatttcgt cactctcagc aatggctttg 617941 acagcatatt tgtccatcac ggctggagtc ccggcgccaa aaagcagctg gaatccggag 618001 ctgccgatta tatgaacgga ttggattttg acggaagctt attttggaga gctgatttca 618061 gcaaaccgcc ccacaattcc tatacgtctt atgattacat aaaaaaggcg gcagaacaaa 618121 agggttataa gctgaagcag gaaacaaatc cgctgctgtt tcaaacatca gatgcaaaac 618181 ctgcaaatga atcttacaat gttcgggtag attatggaac aaataacgtt acaaatcttg 618241 tcgaatacaa ctatgataaa aaagctgaat tttatacaag aagctctgat ggtgtcataa 618301 cgacagaccg ggaaaccgga aagccggttg caatgcaaaa tattttcatt gttgaagcca 618361 gccatcatat tattgatcaa gatggaaggc gggacatcga cttggaatca ggaggaaaag 618421 gtctgttgtt tcagcacgga aacgtcattg aaacagactg gaaacaagtg aatggcagaa 618481 ttgtgccggt aaaagacggc aagtggcttc cgtttgtgcc aggaaagact tggatcaata 618541 tcgtacctga tcttgatgcg gcttccatta gtaaaggaga aggtgtgtaa cgatgcaaat 618601 cgataaatta cgcggcaaag agctggacca gttatttaac tcgatcttat cgctgaaaga 618661 cctggaggaa tgttaccgat tcttcgatga tctatgcaca attaacgaaa ttcaatcgct 618721 ggctcagcgc cttgaagtgg cgcgcatgct tcgcgaagga aacacgtatc ataagattga 618781 aacagaaaca ggcgcttcca cggctacgat ttcccgtgtg aaacgctgct taaattacgg 618841 aaatgacgct tatgaaatgg cgcttgaccg tgtgaaggag acggaaacag agtcttcttc 618901 caaataaaaa accgccctgc cgtctggcaa gggcggtttc tttatgaaac aaattgatgg 618961 atcaggttgt cgatattgat gatactgcca tcctctttcc gatagacaac atgctccttg 619021 gaaaaatgaa tcggcgaatt aatccctgct gcggctgcaa ggttaaatag tccctcgcgc 619081 aatgaaataa cgtagttgca gacacgatgc tgtttttcct caacgctcag tgctttttgc 619141 aatttcggat ctgtcgtcgc cacacctgcc ggacaggtgt tggtgtggca gacgagagcg 619201 cggatgcagc caacggaaaa catcatgccg cgtgcgatgt taacaaagtc agcgccgagg 619261 gctaaggcga ccgcgatttt atcaggagtc aggagctttc cggaagcaaa gattttcagc 619321 tggctgcgca agccgtactg tttaagaagc gtgtccacaa taggcagcgc tgtcataatc 619381 ggaaggccga ctgtatccgc gagctcgtaa aaggaagctc cggtaccgcc ttcacttccg 619441 tcgatcgtga taaaatccgg atgctttccg cttttctgca tatgagagaa aagctcatgc 619501 aattcttcag gatgccctgc gaccagtttg atgccgactg gcttttgtcc gacatctcta 619561 agtttttcaa taaagtcgag catttcagga gggtttgaga attcataaaa gcggttcggg 619621 ctgtcaatcg actttccagg ttcgacattc cgaatgtctg ccacttcctc tgatactttg 619681 gcgccgtcca catggccgcc gcgggttttc gctccttgtg ccagctttag ctcaaacgct 619741 ttaatctggt caatcctgct ttttctttta aattcctccc acgaaaattc cccgtttctt 619801 ttgcgcacgc cgaataggcc cggtccgatt tggcaaatga tatcggcgcc gccctttaag 619861 tgatattcag acaatccccc ttcacctgta ttcatccagg tgccgcctgc cagatggagc 619921 ccttttgaga gcgccgtaac agcccgttct ccaagagaac cgtagctcat ggcagactgg 619981 ccgactaagc ccttcacata aaatggcttc tcgcatgtat gctcgccaat cacctgtaca 620041 tcatcaggat ggagaaaata cgggtctgcc ttgatatgtt cggcatgctc cttgcgtttg 620101 aacagattgt cagcatccat tttatagatt tgggtttcaa tttttggcgt ttgatttaca 620161 tgcatttctt ccctttgttt tggaaacata gcgttacgga tataatagcc aggtttatca 620221 aaatctctta cagatccaaa gcccatcatt ctgcttttgt atttgccgga gatgacggtt 620281 tgctcatatt cctttcgtga aaatggctgc tcttcattgt cattgctgta taaatactgt 620341 ctgagctccg gcccgatttt ttcaaggata taccgaaacc ttccgatgac gggatagttg 620401 cgaagaattg agtgctcctg ctgtttttca tcctttatgt agatccaggc aaacaagacg 620461 atcgggatag cgatgatccc aatgataaat gcgatgagtg ctattatgat ggtttccatc 620521 tctcagcctc cctttttatg taaccatttc cacagtagaa cactttccaa acaatagcag 620581 aaggaatctg gtgaaaaatg tgtgctcctg ccgatacagg actcaccatg caggtactgc 620641 catatgctct ctttttttat gaaaaaagaa tcaaaacacc tttttcagtg aataacgaga 620701 ttaacggctt tttccgtttt tccgcgctat gtgaatttgt tataatgttt aaatggtaac 620761 aaacgaatgg aggaacgtat gacgtgtacg atgtaacgga gtggaagcat gtctttaaac 620821 tcgatccaaa taaagatttg cctgacgaac agctggagat tctttgcgaa tcaggaacgg 620881 atgcggtcat tatcggagga agcgatggtg tgacagagga taatgtcctg cggatgatgt 620941 ctaaggtaag acggtttttg gtgccgtgtg tcctagaggt atcagcgatt gaagcgattg 621001 ttcccggctt tgacttatat tttattccga gtgtattaaa cagcaaaaac gcggattgga 621061 ttgtcggaat gcaccagaaa gccatgaagg aatacggaga actgatgtct atggaagaaa 621121 tcgtggcgga gggctactgc atcgcaaatc cagattgcaa agccgcggca ctgactgaag 621181 cggacgccga tctgaatatg gatgatattg tcgcctatgc gcgtgtgtcg gagctgctgc 621241 aactgccgat tttttattta gaatacagcg gcgtgcttgg agacatagaa gctgtcaaga 621301 aaacgaaggc tgtattggaa acgtccacct tgttttacgg cggcggcatc aaggatgcgg 621361 aaacggccaa gcagtacgca gagcatgcgg acgtgatcgt tgtaggcaat gcggtgtatg 621421 aagattttga cagggctttg aaaacagtag cggctgtgaa aggcgagtag taaattgtac 621481 ggatttggtt tatgatagaa cgtatgtttt gtataggcgg gtgaacaaat tttgaattat 621541 attagcaatc aattactaag cggtttaaac cccgttcagc aggaagcagt caaaacaacg 621601 gacgggcctc ttttgctgat ggcgggagcg ggtagcggaa agacgcgtgt cctgacccat 621661 agaattgctt atttaatggc agaaaagcat gtggcgccgt ggaacattct ggcgatcaca 621721 tttacaaata aagcggcacg cgaaatgaaa gaacgtgtgg aaagcatcct cggacccggc 621781 gcggacgata tctggatctc cacattccac agcatgtgcg tgcggatctt gcgcagagat 621841 atcgaccgga ttgggatcaa ccgaaatttc tccatccttg atacggctga ccagctttca 621901 gtgatcaagg ggattttgaa ggagcgcaat cttgatccga agaagtttga cccgagaagc 621961 atcctcggca cgatcagcag tgcaaaaaac gaattgaccg aaccggagga attctctaaa 622021 gttgctggcg gctactacga tcaggtggtc agcgatgtat atgctgatta tcagaagaag 622081 ctattgaaaa accagtcgct cgatttcgac gatttaatta tgacgacgat taaactgttt 622141 gacagagtgc ctgaagtgct tgaattttat cagcgcaaat tccagtacat ccacgttgat 622201 gagtatcagg atacgaacag ggcacaatac atgctcgtta agcagcttgc cgagcgtttc 622261 cagaaccttt gcgttgtggg ggattctgat cagtcaatct acagatggcg cggcgcggat 622321 atcaccaaca ttctttcatt tgaaaaagat tatccgaatg caagcgtgat tttgctagaa 622381 caaaactatc gttcaacgaa acggattttg cgcgcggcta acgaggtcat taaaaacaac 622441 tctaaccgca aaccgaaaaa tttgtggacg gaaaatgatg aaggcatcaa gatttcctat 622501 tatcgcggtg ataatgagtt cggtgaagga cagtttgtgg ccggcaaaat tcatcagctt 622561 cacagcacag gcaagcggaa gctgtcggat atcgccatat tataccggac aaacgcgcag 622621 tcccgtgtga ttgaggaaac gcttctcaaa gcgggcttga actataacat tgtcggcggc 622681 acaaagttct atgacagaaa agaaattaaa gacattcttg cgtacctgcg cctcgtatcc 622741 aatccggatg acgatatcag tttcacgcgc attgtcaatg tgccgaagcg cggagtcggc 622801 gcgacatcac ttgaaaaaat cgcttcgtat gcggccataa acggcttgtc ctttttccaa 622861 gcgattcagc aggttgattt tatcggcgtc agtgccaaag cggcaaacgc gcttgacagc 622921 tttagacaga tgattgaaaa cctgaccaat atgcaggatt acttatccat tacagagctg 622981 acagaagaaa ttcttgataa gacggaatac agagaaatgc tgaaggctga gaaatcgatc 623041 gaagcccaaa gccgtttaga aaatatcgac gagttcctgt ctgttacgaa aaactttgaa 623101 cagaaaagtg aagacaagac actcgttgcg ttcctgacag acttggcatt gatcgcagat 623161 attgatcagc tcgatcagaa ggaggaagag tcaggcggca aggatgcgat caccctgatg 623221 acactgcacg ccgcgaaagg actggagttt ccggttgttt tcttgatggg gcttgaagaa 623281 ggcgtcttcc cgcatagccg ttcactcatg gaggaagcgg aaatggaaga agaacgccgc 623341 cttgcgtacg ttgggattac aagggcggaa caggagcttt atctgaccaa tgctaaaatg 623401 cgcaccttgt ttggccggac aaatatgaac ccggaatctc gcttcattgc tgaaataccg 623461 gatgatttat tggaaaacct aaatgagaaa aaagaaacaa gagcgacgtc tgcgagaaaa 623521 atgcagccga gacgcggccc tgtttcacgc ccggtatcct acgccagcaa aacaggcggc 623581 gacaccttga actgggcagt cggagataag gcgggccata aaaaatgggg aacaggaact 623641 gtcgtcagcg tgaaaggcga aggagaaggg acagagcttg atattgcctt cccgagccct 623701 gtcggcgtga aacgcctgtt agcagcattt gctcctattg aaaagcagta attgaagagg 623761 aaaggaagaa gcagatggac aaagaaacag cgaagcagcg ggcagaagaa ctgcgccgca 623821 ccatcaacaa gtatagctat gaatattaca ccttagatga accgagcgtc ccagatgccg 623881 aatacgacag attgatgcag gagctgatcg cgatcgagga ggagcaccca gacctcagaa 623941 cgcctgactc tcctacgcag cgcgtcggcg gagccgtgct tgaagcgttt cagaaagtca 624001 cccacggcac accgatgctc agtctgggca acgcctttaa tgctgatgat cttcgtgatt 624061 tcgaccgccg tgtgcgccag tccgtcggcg acgatgtggc gtataatgtg gagctgaaaa 624121 tagacggtct tgctgtttct ctccgttatg aagacggcta ttttgtcaga ggggccacaa 624181 gaggtgacgg gacgacggga gaggatatca cggagaatct gaagacgatc cgcaatatcc 624241 cccttaaaat gaaccgtgag ctgtcgatcg aagtgcgcgg cgaggcgtat atgccgaagc 624301 gttcgtttga agcactcaat gaggaacgga ttaaaaatga ggaagaaccg ttcgccaatc 624361 cgcgaaatgc cgcggcggga tctctcagac agctcgatcc gaaaattgca gcgaaacgaa 624421 acctcgatat cttcgtctac agtatagcgg agcttgacga gatgggtgta gagacgcaaa 624481 gccaagggct tgattttctc gacgaactcg gatttaaaac gaatcaggaa cgaaaaaaat 624541 gcggcagcat agaagaagtc attacgctga tcgatgagct tcaggcgaag cgcgcggacc 624601 tgccgtacga aatagacggc attgtcatta aagtcgattc tctcgatcaa caggaggagc 624661 tcggttttac ggcgaaaagc ccgcgctggg ccatcgcgta taagtttcct gctgaagagg 624721 tcgtgacgaa gcttctcgat atcgaattaa atgtcggcag aacgggtgtg attacgccga 624781 ctgcgattct tgagccggta aaagttgccg gcacaacggt ctcaagagca tcccttcata 624841 acgaagattt aattaaagag aaggacattc ggattttgga taaggttgtc gtcaaaaaag 624901 cgggcgatat catcccggaa gttgtgaatg tcctcgttga ccagcgcaca ggagaagaaa 624961 aggaattcag catgccgacg gaatgtcctg aatgcggcag tgaactcgtc cggatcgaag 625021 gagaagtggc gcttcgctgc attaaccctg aatgtccggc gcaaatccgg gaagggctta 625081 tccatttcgt ttcccggaat gccatgaaca ttgatgggct cggcgaacga gtgatcacac 625141 agctgtttga ggaaaacctt gtccgcaatg tggcagattt atataagctg acgaaggaac 625201 gagtcatcca gctcgagcgc atgggcgaaa agtccactga aaacctgatc agctccatcc 625261 aaaaatcaaa agaaaattcg ttagagcgcc tgctgtttgg gcttggcatc cgttttatcg 625321 gatcaaaggc cgcaaagacg cttgccatgc attttgaaag cttggagaac ctgaaaaaag 625381 cctctaaaga ggaacttctc gcggtagatg aaatcggtga aaaaatggct gatgctgtga 625441 tcacctattt tcataaagaa gaaatgcttg aactcttgaa tgaacttcag gagctgggcg 625501 taaacacgct ctacaaaggc ccgaaaaaag taaaagcaga ggacagcgac tcttactttg 625561 ctggtaaaac aattgttctg acaggaaagc tggaagagct gtcaagaaac gaagccaaag 625621 cgcaaatcga agcgctgggc ggaaagctga ctggaagcgt cagcaaaaac acagacttag 625681 tcatcgccgg agaagcggcg ggaagcaagc tgacaaaagc acaagagctg aacattgaag 625741 tgtggaatga agaacagtta atgggagagc taaagaaata agaggagtgt tttctattga 625801 aaaagacgtt ggcattggcg gcaacggcgg cagtattaat gctgtctgcc tgctcgtcag 625861 gtttcggggg ggagaaggag gaagagatta cgcaaaagac ggcgaaatcg tcagaaaaag 625921 cgattgtccc gaaatataat atctctgact cctattacaa aatggtgctg ccgtttaagg 625981 caggcaaagc gcgcggctta acaacggaac agctgaatac aaggctggac attgacgaat 626041 ttgaaacagg gctgatgcgc cttgcccaag attctttctc aactgacgat tatctgttcc 626101 aagaaggaca atatttagat gaggatacag tattaagctg gctggcacgg aaaaaaacgg 626161 gctctgattt gaaaaaagcc gaaaaagaag ataagaactt caaaaatgaa ggcttgaacc 626221 cggcgctccc gagttctggt tcaacagaag aaaagaacga aagcagccca atttatttag 626281 catccatgct tgagcacgat tatttagtca gaaaagacaa gaattctatc cagcttggcg 626341 gcgtcatgat cggactggcg ttaaactcag tgtattacta tcgtgaaaaa actggcgacc 626401 cgcaaaaaga agtggagatt aaagacagca cgcttcgcca gcagggagaa aaaattgcac 626461 aggaggttat taaccgcctc cgcaaaaaag ataacttgaa gaatgtgccg attaccgtgg 626521 cgctctacaa gcaggcgtca aaaacatcga ttgtgccggg gaacttcatc gccaaaacag 626581 aggtcaaagc aggctctact gatatctcaa attgggatga catcaatgaa aaatatgtat 626641 tctatccggc ggatacaacc acagcagaaa agtacccgga tgacaccgag gtctttaagc 626701 ggttcaaaaa ctcaattgaa gaatatttcc cgaactatac aggcgttgtc ggtacagcgc 626761 tgtatgaaaa tgatgaaatg aagaaaatga agattgacat accaatgcaa ttctacggaa 626821 aaagtgaagt tgtcgcgttt acccagttct taacgggtga agtgatggac tactactcta 626881 agagctcagt tgatgtcgaa gtcaatatca cgtcctcaga cggacaggaa gcggtcatta 626941 tccgcaatgc cggagataaa gagccgactg ttcacattta tgactgatag aaaacccttg 627001 tgccatattg gcacaagggt ttttatgtta caattaacag gaaaagggaa aatattttca 627061 cttctgccga aacacaaatc aaggggaggt atgttgatgc tggaaatcgt gtgaaaacaa 627121 tcattatcaa atctatagca atgaaaggat gttagacgtg cataaagata tcaaaaaaat 627181 atttcatgaa gagcaggttt tggcagaagc tgcagcgaga tacggtttct caaaagatca 627241 ggtgcgtttt ctggctgatg cggaaaacta tgtatatgaa tgtatgaaag acaatcaacc 627301 ttatatttta aagattaccc atacgattcg gagatcttct gattatatga tgggagagat 627361 ggaatggctc cgtcaccttg caataggggg aatttcagta gccaaaccgc tcccgtcgct 627421 gaacggaaaa gacgtagaag cagtgccgga cggaaacggc gggtcatttt tattgagagt 627481 gtatgagaaa gcgccggggc aaaaagtgga tgaatcggac tggaatgaaa cgctatttta 627541 tgagcttggc agatacacag gcagcatgca cagcctgaca aaaagctaca aattgagcaa 627601 tcccgctttc aaaagacagg aatgggatga agaggagcaa ttaaagctga gaaaatatgt 627661 gcctgaagat cagataaagg tgtttcagca agccgattct ttgatgaatg aactgcggag 627721 gctcccgaaa agccaggaca actacggctt ggtgcatgcg gatctgcacc atggcaattt 627781 taactgggat catggcaaaa tcacggcatt tgattttgat gatatcggct acaactggtt 627841 tgttaacgat attagcattc ttctctacaa tgtcctgtgg tatcctgttg tgccatatga 627901 tgataaagct gcgtttacag aagaatttat gacgcatttt atgaaagggt actgggagga 627961 aaatgagctt gaccctgcat ggctgatgat aatacctgat ttcctccgcc ttcgccatat 628021 gctgatttac ggattgctgc atcagatgtt tgaccttaac acaataggag aagaggaaaa 628081 agaaatgctg gccggtttca gaagagatat agagaatggc acgccgatta cagcatttga 628141 tttttcagca ctggtgtaga tagaaaaagc caatgggatt ccagtcccat tggcttttat 628201 aatgtatcac acttcacgcc gactacgcct tcaatggctt taatgtcata gtagacatcg 628261 gtcgtgtatc tgtttttatg gacgcggacc ttcacttcca taattggaaa atccttttcg 628321 cctaggtcgt cgatccgaac ggagtgtgct ttgatatctc ttcttttcat ttcttttaaa 628381 atctctgtca ttttgtcttt atcagaaagt gacattctga tgcggatgtc tttttcctgc 628441 aggcggtcgg ggccgatttt tctgaccacc catgggagaa attccacact gatcaggatg 628501 aacagaagac tggcaaacgc ttctttataa aaaccggctc ccgtagcaag cccgagcccc 628561 gctgcccccc agatcatggc cgatgtcgtc aggccggaaa tgacatcatt gctttttcgc 628621 aggatgacac cggcgccgat aaacccgacg ccggagatga tttgtgccgg cagacgaagc 628681 ggatccatca tgatgcggta gtatttaggg aaatgatatg ccgcattaat actgacgatc 628741 gtcagcatgc atgagctgac tgcgatgaca atacaggttt ttaatccgag cggcttattt 628801 tttaattcgc gttcaagccc gatgaccatg ccaatcaatg tggcaatgcc caatttcaat 628861 aaaatatcag gatcaatata ccagctcaac agcaaacttc ccccttctct atggtgtttt 628921 taaataaata tgattttctc acagtattta tagcaaaaca agagcacaaa agccaccaag 628981 ctgcgcttga tggcttattg cttacttttt gcgttttaac agcttttcca tgacaccgaa 629041 taatcggtaa gaggcttttg caggacgttt tgtgatcatg ctgacaatga tgccggcaat 629101 catactgaga ataaacccag ggatgatttc gtacacaccg gttgattttg ccaggccggt 629161 tgtaatccag atcaacacgg tcgcagcccc gacaatcatg gcagcaagcg cgccccattc 629221 gttcattcgt ttccaataca gactgagcag aatcgcaggc ccgaaagctg aaccgaagcc 629281 ggcccaagcg tatccgacca aatcaagaat ggtgctgttc gggttcaatg acaagagtac 629341 cgcgataacg gcaatgacta agacggacaa tcgcccgatc atgaccaatt ctttatcaga 629401 agcttttcgt ctgaaaaatg accggtataa atcctctgtt acagcacttg ctgtgaccaa 629461 gagctgtgag gaaatcgaac tcatgatggc agccaaaata gctgacaata agaaccctgt 629521 aattaatggg tggaacaaga ttttagagaa gataatgaaa atcatctccg gatcttttac 629581 agcaactccg aatttatggg cgtatgcaac accgattaaa cccgtcagca cggaacctag 629641 aactgtaatg atcatccagc tcatgccgat tcggcgtgca ggttttaaat ctttaatgtc 629701 tttaatggcc ataaatcgga cgatgatatg aggctggccg tagtagccca acccccaggc 629761 taaataggaa ataatgctaa tgacgctcgc gcctttaaaa atatccaata aatgtggatt 629821 aacagcgtcg atttcatgga aagtcggagc aacgccgccc acatgggtaa aagcaacgat 629881 cggcacaagc actagtgctg caaacatgat cgcaccctgc acgaagtcag tcagactgac 629941 agcaaggaaa ccgccaaaca gtgtgtataa cacgacaact gcggtggtca gaaacaggcc 630001 taatttgtaa tccgcaccaa aagcagattc aaacagccgt ccgccagata ccataccgga 630061 agaggtatac aatgtgaaaa agatcatgat gatcaatgca gatacgattt tcagcagtga 630121 tgaagaatgc tggaatcgtt tatcaaagaa atcaggaatt gtaatcgcat catctgccgc 630181 ttctgtataa gcacgcagcc ttggagccag cagcaagtaa tttgagtacg ccccgattgt 630241 aagacctaaa gcaagccata aggtggacag ccctgtcgca aacatcgcgc cgggaacacc 630301 catcagcatc catccgctca tatcggccgc gccggcagac aaagcagtaa cgaatggtcc 630361 gaggcctctt cctccaagca tgtaatcatt gatgtcagtg gttttcttga atgcatacca 630421 gccgattaac agcatggcaa taaagtaaat tcctaaagat ataataattt caatactcac 630481 gttttaccct ctcttcattt ctaataatgt tgcatcacct ctcaaattga tggtgccagt 630541 taagcagcct ggcgtaagtg caaaacaaaa gaaattcttt tgcgggtgca cttggtaact 630601 taacctaaca aagtattccc ggccattcaa gcgatgaaac attgatcata agctggaaat 630661 accgttgcaa acctagaagg gaataaagaa taaaacgctt tcaaaaaata attaaagtaa 630721 aaatattcag aaaaatattt cgtttctcct tctcctcatt ttagtataaa atatataggg 630781 tattgtttcg aaaacacagg cctgtctcaa ggcgttttgt tgctttaaag ggcttgtttt 630841 tgatatgatc agtattatat gacttaacgg agaaatatgt ggaggtggat catatgtcac 630901 gaatttcaat agaagaagta aagcacgttg cgcaccttgc aagacttgcg attactgaag 630961 aagaagcaaa aatgttcact gaacagctcg acagtatcat ttcatttgcc gaggagctta 631021 atgaggttaa cacagacaat gtggagccta caactcacgt gctgaaaatg aaaaatgtca 631081 tgagagaaga tgaagcgggt aaaggtcttc cggttgagga tgtcatgaaa aatgcgcctg 631141 accataaaga cggctatatt cgtgtgccat caattctgga ctaaaggagg gacacaagaa 631201 tgtcattatt tgatcataaa atcacagaat taaaacagct catacataaa aaagagatta 631261 agatttctga tctggttgat gaatcttata aacgcatcca agcggttgat gataaggtac 631321 aagccttttt ggcattagat gaagaaagag cgcgcgcata cgcgaaggag cttgatgagg 631381 cggttgacgg ccgttctgag cacggtcttc ttttcggtat gccgatcggc gtaaaagata 631441 atatcgtaac aaaagggctg cgcacaacat gctccagcaa aattctcgaa aactttgatc 631501 cgatttacga tgctactgtc gttcagcgcc ttcaagacgc tgaagcggtc acaatcggaa 631561 aactgaacat ggacgaattc gccatggggt catctacaga aaactcagct tacaagctga 631621 cgaaaaaccc ttggaacctg gatacagttc ccggcggttc aagcggcgga tctgcagctg 631681 cggttgctgc gggagaagtt ccgttttctc ttggatctga cacaggcggc tccatccgtc 631741 agccggcatc tttctgcggc gttgtcggat taaaacctac atacggacgt gtatctcgtt 631801 acggcctggt cgcatttgcg tcttcattgg accaaatcgg accgattaca cgtacggttg 631861 aggataacgc gtttttactt caagcgattt ccggcgtaga caaaatggac tctacgagtg 631921 caaatgtgga cgtgcctgat tttctttctt cattaactgg cgacatcaaa ggactgaaaa 631981 tcgccgttcc gaaagaatac cttggtgaag gtgtcggcaa agaagcgaga gaatctgtct 632041 tggcagcgct gaaagtcctt gaaggtctcg gcgctacatg ggaagaagtg tctcttccgc 632101 acagtaaata cgcgcttgcg acatattacc tgctgtcatc ttctgaagcg tcagcgaacc 632161 ttgcacgctt tgacggcatc cgctacggct accgcacaga caacgcggat aacctgatcg 632221 acctttacaa gcaaacgcgc gctgaaggtt tcggaaatga agtcaaacgc cgcatcatgc 632281 tcggaacgtt tgctttaagc tcaggctact acgatgcgta ctacaaaaaa gcgcaaaaag 632341 tgcgtacgtt gattaagaag gatttcgagg acgtatttga aaaatatgat gttattgttg 632401 gaccgactac accgacacct gcgtttaaaa tcggtgaaaa cacgaaggat ccgctcacaa 632461 tgtacgcaaa cgatatctta acgattccgg tcaaccttgc cggcgtaccg ggaatcagtg 632521 tgccatgcgg attagcagac ggacttccgc tcggcctgca aatcatcgga aaacactttg 632581 atgaaagcac tgtataccgc gttgctcatg catttgaaca agcaacagac catcataaag 632641 caaaacctga actgtaaggg gtgaaaagaa ttgaactttg aaacggtaat cggacttgaa 632701 gtccacgttg agttaaaaac aaaatcaaaa attttctcaa gctctccaac gccattcggc 632761 gcggaggcga atacgcagac aagcgttatt gacctcggat atccgggcgt cctgcctgtt 632821 ctgaacaaag aagccgttga attcgcaatg aaagccgcta tggcgctcaa ctgtgagatc 632881 gcaacggata cgaagtttga ccgcaaaaac tatttctatc ctgacaaccc gaaagcgtat 632941 cagatttctc aatttgataa gccaatcggc gaaaacggct ggatcgaaat tgaagtcggc 633001 ggcaaaacaa aacgcatcgg catcacgcgc cttcatcttg aagaggatgc cggaaaactg 633061 acgcatacgg gcgacggcta ttctcttgtt gacttcaacc gtcaaggaac gccgcttgtt 633121 gagatcgtat cagagccgga catccgcacg ccggaagaag cgtacgcata tcttgaaaag 633181 ctgaaatcca tcatccaata tacaggcgtt tctgactgta aaatggaaga aggctcactt 633241 cgctgtgacg ccaatatctc tcttcgtccg atcggccaag aggaattcgg cacaaaaaca 633301 gaattgaaaa acttgaactc ctttgcgttt gttcaaaaag gccttgagca tgaagaaaaa 633361 cgccaggagc aggttcttct ttccggcggc gtcatccagc aagaaactcg ccgttatgat 633421 gaagcaacga agaaaaccat tcttatgcgt gtcaaagagg gatctgacga ctaccgttac 633481 ttcccagagc cagatctagt cgagctctac attgatgatg aatggaagga acgcgtaaaa 633541 gcaagcattc ctgagcttcc ggatgagcgc cgcaagcgtt atatcgaaga gcttggcttg 633601 cctgcatatg acgcaatggt tctgacgctg acaaaagaaa tggctgattt cttcgaagaa 633661 accgttcaaa aaggcgctga agctaaacaa gcgtctaact ggctgatggg tgaagtgtca 633721 gcttacctaa acgcagaaca aaaagagctt gccgatgttg ccctgacacc tgaaggcctt 633781 gccggcatga tcaaattgat tgaaaaagga accatttctt ctaagatcgc gaagaaagtg 633841 tttaaagaat tgattgaaaa aggcggcgac gctgagaaga ttgtgaaaga gaaaggcctt 633901 gttcagattt ctgacgaagg cgtgcttctg aagcttgtca ctgaggcgct tgacaacaat 633961 cctcaatcaa tcgaagactt taaaaacgga aaagaccgcg cgatcggctt cctagtcgga 634021 cagattatga aagcgtccaa aggacaagcc aacccgccga tggtcaacaa aattctgctt 634081 gaagaaatta aaaaacgcta ataaaaaagc agcccttaga ggctgctttt tttatggtca 634141 aattgagata aagacaagat gagggcccga agcctttcaa cttctttgtc gttggttccg 634201 gccaaattgg acagcatgcc tttaataatc ggcttgcgcg gtttatcctg agtcaattct 634261 tcctcgataa catcaagtga cacggtgata tcctcgggca gcgtgctgtt ttctttcact 634321 ttctgaatgt cctcaagcag ctggtctttt cccgcaggca tcgggttaaa aatgtctttt 634381 gatacaatcg gattgagtgc agaacggctc agcccctgta caagatcatc cagtctctca 634441 ataataaagg ctgagatttc ttctgcatcg atattaagct caccgttaaa taccatcacg 634501 ttcatatagg aatgcacaat gcctcttgcc atgatggaca gatctgcgac ataccgctcg 634561 attccttcgc cataggatac cagcaaggcg ttccggtaca gcttatccgt ctccatggtt 634621 actttgtaaa agtattgctt gatttcttga ttttccggaa tgatattttc ggtaagcaaa 634681 agaacgataa aatctttatg atcgcgaaaa tcctcaaatt gagcgccaat ttgctttttt 634741 aacacttcct taggcggctt tccggcgaga tcttcttcta tatttttcat tttgttcata 634801 gacataccga tataatattc acaggcagat aacagcagcg cttctttcga tttgaagtgc 634861 aaataaaaag cgcccttcga aatgccgcat tcactggcga tttcttggat cgtcgtagct 634921 gcgaatcctt ttttcgcaaa taaacgaatg ctggttttta tgattctctc ttttttttca 634981 ttcatgacgt gcttcccctt aatccttgaa aaatttagta aaattttctg gtatatgagt 635041 tgacgttgtt gcgttataac gtttagtatt atatagaatg accagtcagt caataaaaaa 635101 tgtaatggag gatatgatga accacgttat taatttcgtt ctgaaaaaca aattcgccgt 635161 atggctgatg acgattattg taacggcagc cggcttgtat gcgggtatga atatgaagca 635221 agagtctatt cctgacgtga acatgcctta cttgacgatc agcacgacat atccgggtgc 635281 aacaccaagc caagtggctg atgaagtgac caaaccggtt gaacaagccg tacagaactt 635341 ggacggtgtc agcgttgtga cgtcgacgtc ctatgaaaac gcatcgtcgg tcatgattga 635401 atatgattat gagaaagata tggacaaagc gaaaacagaa gcagctgaag cgttagaaaa 635461 cgtcaacctg cctgatgacg cgaaggatcc ggagatttca cgctacagct tgaactcatt 635521 cccgattctg acgctgagcg tgtccagtga taaagataat ctgcaagagc tgacgaaaca 635581 agtggaggac agcctcgttt ctaagcttga aggcatagaa ggcgttgcgt ccgtccaagt 635641 atcaggccag caggtggaag aggttgaatt ctctttcaaa gaagacaaac tgaaggaata 635701 cggccttgat gaagatacag tcaagcaagt gattcaaggt tcagatgtga caactccgct 635761 tggattgtac acattcggaa atgaagaaaa atctgtcgtc gtcagcggcg atattgaaac 635821 aattaaagat ttgaagaata tgagaatccc gacggcatct gcttcaagtg caggcagcag 635881 cgcagcatct caagcaggtg cgcagagtgc tcaagcagcc caaagcgcgc aagcggcagc 635941 acaggtgcag caaagcgcaa gcacagcagt gccgacggtc aagctttctg acattgctac 636001 aattaaagat gtgaaaaaag ctgaatccgt ttcacgcaca aatggcaaag acagcatcgg 636061 catcaacatc gtcaaagcaa acgatgcgaa tacggtagag gttgccgacg atgtcaaagc 636121 tgagctgaaa aagttcaaag aagaccataa aggcttcaat tacagcgcaa ctctcgacat 636181 ggcggagccg atcacacagt cagttgacac gatgttaagc aaagccatct tcggtgctat 636241 ttttgcgatt gtgattattc tcttattctt aagagatatc aaatcaacat taatttctgt 636301 tgtttcaatt ccattatcat tgctgatcgc actccttgtg ctgcagcagc ttgatatcac 636361 attgaatatt atgacgctcg gcgcaatgac cgttgccatc ggacgtgtag tcgatgactc 636421 catcgttgtg atcgagaaca tttaccgccg catgagactc aaagatgagc cgctccgcgg 636481 aaaagccttg gttcgtgaag cgacgaagga aatgtttaaa ccgatcatgt catcaacgat 636541 tgtgacaatc gcggtattcc tgccgctcgc acttgtaggc ggacaaatcg gtgaattgtt 636601 tattccattt gccttaacga ttgtttttgc gcttgccgca tccctagtga tttcaatcac 636661 gcttgtgccg atgctcgcac acagcctgtt caaaaaatca ttaaccggtg cgccgattaa 636721 agcgaaagaa cacaaacctg gcagacttgc aaacatctat aaaaaagtat tgaactgggc 636781 gctgagccac aaatggatca cgtctatcat cgcggttctg atgctccttg gaagcttgtt 636841 cctcgtaccg ttaatcggtg ccagctacct gccgtccgag gaagaaaaaa cgatgcagct 636901 cacatacagc ccagaaccgg gtgaaacgaa aaaagaagcc gaaaatgaag ctgaaaaagc 636961 ggaaaaaatc ctgcttgacc gcaagcatgt cgatacggtt cagtattcat taggctctgg 637021 cagcccgctt gccggaggag attctaacgg tgcgttattc tatatcaaat atgaaagcga 637081 cacacctgac tttgataaag aaaaagataa cgttctgaag gaaatccaaa agcaatctga 637141 ccgcggagaa tggaagtcac aggacttcag ctcttcaggc aataataacg aattaacata 637201 ctatgtgtat ggcgattctg aaaacgatat taaagacacg gtcaaagaca ttgaaaaaat 637261 catgaaagat gaaaaggatc tgaaaaacgt aaattcaggc ctttccagca catatgatga 637321 gtacacattt gtcgctgacc aagaaaaact aagcaagctc ggtttaaccg cgtctcaaat 637381 ttctcaggcc ttaatgtcac aaacatcgca agaaccgctc accactgtga aaaaagacgg 637441 caaagagctt gatgtgaaca ttaagacaga aaaagacgag tataagagtg tgaaagattt 637501 agagaataaa aagatcactt ccgcgactgg ccaggaagtc aaaatcggcg atgtggcaaa 637561 agtgaaagaa ggatcaacat cagataccgt gtcaaaacgt gacggaaaag tctatgcaga 637621 tgtcacaggt gaggttacct ctgacaacgt cacagccgta tcagctgcta tccagaagaa 637681 aatcgataag cttgaccacc ctgataacgt atcgattgac acaggcggcg tatcagcgga 637741 tatcgctgat tccttcacga agctcggttt agcgatgctg gcagcaatag cgatcgttta 637801 ccttgtgctc gtgattacct tcggcggagc actagcgcca tttgcgattc tgttctcatt 637861 gccgttcaca gtcatcggtg ccctggtcgg actttacgta tcaggtgaaa cgatcagtct 637921 gaacgccatg atcggtatgc tcatgctgat cggtatcgtt gtcacgaatg ccattgtctt 637981 aattgaccgc gtgattcata aggaagcgga aggcctgtct acgagagaag cgctcctgga 638041 agccggctct acacgactcc gtccgatcct gatgacagcc attgcgacaa tcggcgcctt 638101 gattccatta gccctcggct tcgaaggcgg aagccaggtc atttcaaaag gactcggcgt 638161 aacggttatc ggcggtttaa tcagttcaac gcttctgacg ctcctgatcg tgccaatcgt 638221 atatgaagta ttggcgaagt tccgcaagaa aaaaccggga acggaagaag agtaaaaaac 638281 aaaaagcctc agctctgctg aggctttcag cttgttgaaa aaccctcgca ttcgttgtca 638341 ggtctgcgcg tcggtgctca cgaattctac attcgctccg ctccaatgct cccccttcct 638401 agactacaag ggttttcaat caagctgaaa gaatgttaag gatgacaaaa gctcaaaaca 638461 agaatcagtt ttgagctttt gtgcgttttc acctgtaaga ttatgtacat tttgttgcga 638521 tttttttaac tcatagtata attaaaggtt gttagtgtaa aaatggatcg gatactctta 638581 agtaggatga tgagataatg aaacgtgcac gcataatata caatccgact tcaggacggg 638641 agatctttaa aaagcatctt gcccaggtcc tgcaaaaatt tgaacaagcc ggctatgaaa 638701 cctccaccca tgcgacgaca tgcgcaggag acgctacaca cgctgccaag gaagcggcat 638761 tgcgtgagtt tgacctgatc attgcggcag gcggagacgg aacgatcaac gaggtcgtca 638821 acgggcttgc gcctttagac aatcgtccga cactcggtgt gattcctgtc ggcacaacga 638881 acgacttcgc cagagcgctc ggaatcccac gcgaggatat tttaaaagcg gcagatacgg 638941 tcattaacgg cgttgcccgc ccgattgata tcggacaggt caacggccag tattttatca 639001 atatcgccgg cggaggccgt ctgacggagc tgacgtacga cgtgccaagc aaactgaaaa 639061 caatgctcgg ccagcttgct tattatttaa aaggaatgga aatgctgcct tcacttcgtc 639121 cgacagaagt cgagattgaa tatgacggca agctgtttca aggtgaaatc atgctgtttt 639181 tggtcacgct gacaaactcc gtcggcgggt tcgaaaagct cgcgccggat tccagcctga 639241 atgacggcat gtttgatttg atgatactaa agaaagcaaa ccttgctgaa tttatcaggg 639301 tcgccacgat ggcgcttcgc ggagaacaca tcaacgacca gcacattatt tatacaaaag 639361 cgaaccgcgt gaaagtcaat gtatcagaaa agatgcagct gaacctggac ggcgagtacg 639421 gcggcatgct gccgggcgaa ttcgtgaatc tgtaccggca cattcacgtc gtcatgccga 639481 aggagaaagc ggaacagttg gatgactaaa acttggcttg gtaagccaag ctcagaatgt 639541 tgacaaaatc ctaaaacagt tttcgtttta ggattttgtc atcttttcag cgtgattgaa 639601 aacctttgaa gtctaggaag ggcgagcatc ggagcacagc gaatgttgaa ttcgtgagca 639661 ccgaagcaca ggcctgacaa cgaatgcgaa ggtttgccta cacgctgaaa cttggcttga 639721 ataggccaag tttttctttc gcttaaaact agaggtgatt atagatgaaa atgaaacccc 639781 cagtagaaaa aaatgaatac tacgatgtga catttgagga tttgacacat gaaggagcgg 639841 gcgtcgcaaa ggtccaaggc ttcccgatct ttgtgccgaa tgccctaccc gaggaaaaag 639901 cccaaatcaa agtgacacgc gtcaaaaaag ggttcgcctt cggccgcctg attgagctga 639961 aggaagaaag cccgcataga acggacgccc catgcccgat ttacaaacaa tgcggaggct 640021 gccagcttca gcacatgacc tacgaaggcc agctcctgtt taaacagaaa caagtcaaag 640081 acgtcttaga acgcatcggc aagctggacc tttcaaaagt caccgtgcac ccgacactcg 640141 gcatggaaga cccgtggaac tacagaaaca aagcacaggt gccggtagga gaacgggaag 640201 gcggactcgt cgcgggattc tatcagcaaa gaagccatga catcatcgac atgagcgcct 640261 gcctgatcca gcaatccaaa aacgacgaag ccgttcaagc tgtcaaagac atttgcgcaa 640321 actacggtgt caaagcctac aacgaagaac gccacaaagg ctggctccgc cacatcatgg 640381 tcagatacgg cgttgttacg ggcgaaatga tgatcgtctt catcacaaga acaagcgact 640441 tcccgcacaa agcgaagatc atcgaagaca tcacagcgca attcccgcac gtcaaatcca 640501 tcgtgcaaaa catcaaccca aacaaaacaa acgtcatttt tggcaacgaa acaaacgtca 640561 tctggggcga agaatacatc tacgacctca tcggagacgt caaattcgcc atctccgcca 640621 gatcgtttta tcaggtcaac ccagagcaaa caaaagtgct ctacgacaaa gcgcttgagt 640681 acgctgagct tcaaggggaa gaaaccgtca tcgacgctta ctgcggcatc ggaacgattt 640741 ctctcttcct ggcaaagcag gcgaaaaaag tgtacggtgt agagattgtg ccggaagcaa 640801 ttgaggacgc gaagcgaaac gccgaattaa acggcaacac aaacgcagag tttgctgttg 640861 gagaagcgga aaccgtgatt ccaaagtggt acgaagaagg cattacagct gatacgctgg 640921 tcgtcgaccc gccaagaaaa ggctgcgacg aagccctcct gcggacaatt gtggagatga 640981 agccgaagcg ggtagtgtat gtgtcctgta atcctggcac gcttgcgaga gatttgcggg 641041 tgcttgagga tggcgggtac gtgacgcgcg aagtgcagcc tgtggatatg tttccgcata 641101 cgaatcatgt ggagtgctgt gtgttgataa aattaaaaga ataaatagtc aaaaatctat 641161 gctgatggaa ctgttggttc tctaaaacga taattgattt caatggttcc atttgcatgt 641221 acttctattt catctactaa caaatgaagc atttcggggg taagtgtacc ttccttcatg 641281 aatttatcta agctcttttt aaaatcaatt atttcttttt caatcttttg aaattctagg 641341 tccttagata gttggtgaag ggtagtttca aaatttgaaa tatcttcatt ggtgatattt 641401 atggctaatt ggtaatcttc tttagatata acaccattag caagagagat aactaaattg 641461 gatttatctc tctttttatc gtttaatttt tcattaattt cgattatctt agattcgatt 641521 ttttctttgt actttaacgc tttttcactt aattctttaa aataattttc cttactgaat 641581 ttcaaatata tcttatttag gttggttatt actttatcag ttaaatctat ttcacttacg 641641 taatgatcac tacatgcttt taaaccatgt ttattataac ttccacaaac ataacctttt 641701 cgattctttt taaaatgcat tgacctcctg caatctttgc aaaccgcagt atttgtaaag 641761 agatgtactt cagcttgagg tctccttctt tttctagtta ttaaaatctc ttgtacaata 641821 agaaagtctt ctaaaggtat gattggttcg tggctttttt caataattat ttggttttct 641881 aggttaactg accttcttct tttactggta acactcggtc tatattctct acattgttgt 641941 agtgtcccag tatagtgagg attttcgaga atttttctta ttgaagatcc gtgccatttg 642001 tcagtagcgt tctttttgcg ggcaagctgc gagggactag tgaccccttc gttatacaat 642061 ccccttgcta ttgcatcaaa gccttttcca gcaatatatt ctgaaaagat tctaatattt 642121 actattttct ctgcgtttgc tgaatttgag agagatatga ttgtagaacg aactcaagaa 642181 ggtaaaatgt tggccaagca gaatccggat ttccgagaag gaagacccaa aaagttcaca 642241 aagcagcaaa tcaatcatgc attaacatta ctagaaaatc attcgtataa acaagttgaa 642301 gatatgactg ggatatcagt ttctacactt gtaagagcta aaaagaagaa agctgctgaa 642361 gctataaatg gataaatatt gtgaattaat tattcaatat cttgagaaat ttttataaaa 642421 gtaatcaaaa gtttaatggg ggaaacgaaa tggcgctcat tgatttagaa gataaaattg 642481 ctgaaatagt gaatcgagaa gatcattcag atttcttgta tgaattactc ggtgtatatg 642541 atgttccacg agctacaatt acgcgcttga aaaaaggaaa tcaaaacctt acaaaacggg 642601 ttggtgaagt acacttaaag aataaggtgt ggtttaagga ggctaagaaa ggaaagctct 642661 ttgacgccct tattgatata gaacaacaag ttgaatatct ttcagctaag ccacgatatt 642721 tattagttac tgactatgat ggagtattag cgaaagatac aaaaacatta gaggctcttg 642781 atgttaaatt tgaagaactt cctcagtatt tcgatttctt ccttgcttgg aaaggtattg 642841 agaaagtaga gtttgaaaag gaaaaccccg ctgatattaa agcagccgaa cgttttgcac 642901 ggatatatga tgtacttcgt aaagaaaaca atattattga gactaataga gggttagatt 642961 tatttcttat tcgtttactg ttttgttttt tcgcagaaga tactgacatc ttcaaacgaa 643021 atagttttac gaatttaatt aagactttga ctgaagaaga tggttcaaat ctaaataaat 643081 tatttgctga tttatttatc gtgttagata aaaatgaacg agacgatgtt ccatcttatt 643141 taaaagagtt tccgtatgta aatggccagt tgtttactga accacataca gagttggaat 643201 tttctgccaa atccagaaag ttaattattg agtgcggtga attattaaac tgggctaaaa 643261 tcaatcctga tatctttggt tcaatgattc aagctgttgc ttctgaagaa agccgtagtt 643321 atttaggtat gcactacaca agtgtcccca atataatgaa ggttattaaa ccgcttttcc 643381 tagataaact taatcagtct tttttagatg catacgatga ttatacaaaa cttgaaaatc 643441 ttctaacacg aatcggcaaa attaaattct ttgatcctgc atgtggttca gggaactttt 643501 tgattattac ctacaaagaa ttacggcgta tggaaatcaa tattataaaa cgacttcaag 643561 aactcttggg agagtatctt tatgtacctt cagtaacttt atctcaattt tacggaatag 643621 agattgaaga ttttgcacat gacgttgcaa aattatcact ttggattgct gaacatcaaa 643681 tgaatgaaga attaaaaaat gaagttcata atgcagtacg cccaacgtta ccacttcata 643741 cagcagggga tattcgttgt gcaaatgcta ttagggttga gtggactgag gtttgtcccg 643801 cacaaggatc tgaagaagta tatgtttttg gtaatccacc gtatcttggt tcaaaaaaac 643861 aaaacaaaga acataaatct gatatgttat caatttttgg aaaagtcaag aatggtaaaa 643921 tgcttgatta tatttctgct tggttttact ttggtgctaa atacgcttca actacaaatg 643981 caaaagttgc ctttgtatca acaaattcag ttactcaagg ggaacaggtt tctatcttat 644041 ggaatgagtt attcaagttt ggaattcaaa tcaattttgc ctataaatct tttaaatggg 644101 cgaataatgc taaaaataat gctgcggtaa ttgttgtgat tgtaggtttt ggcccgttag 644161 ataccaaagt aaacaagtat ttatttgttg atgaaacgaa aaagctagtt tctaacatta 644221 gtccctattt aactgatggt gaaaatattc ttgtttcttc taggacgaag ccaatttcag 644281 acttacccaa actgcatttt gggaacatgc ctaatgatgg cggaggatta ctctttacca 644341 ttacggaata tacagacgca atcaataagt atcctgaatt agttccctat tttaaaaagt 644401 ttataggttc agtagagttt attaatggtg gtttacggta ttgtttatgg cttaatgaag 644461 caaaatatga aaaaataaag tctaatcctc taatacaaga aagaatctca atttcaaaaa 644521 atcacaggga aaaatcaaca gataaaggaa cgaataaact tgcattaact ccgtggaagt 644581 ttagagatac tcatgaaaca actaattatt ccattgttgt tccatctgtg tcttctgaaa 644641 atagatttta tattccaatg ggattagcag gtgcagatac aattttgtca aatctaattt 644701 atgtaattta cgatgcagaa atttaccttc taggcatttt gatgtcacgg atgcatatga 644761 cttgggtaaa agctgtagcc ggaagattaa aaactgacta taggtactct gcaggtttat 644821 gttataacac tttccctatt cctgaattat caacaagaag gaagaatgaa attgaagaag 644881 caattcttga aattcttgat cttcgtgaag agcagggtgg tacattagca gagctttata 644941 acccttcaac aatgccaatt gaattaaaag tagcacatga aaagttggat ggaattgtag 645001 aaagagcgta tcgtcaaaaa caatttgaat ctgatgaaga acgcttagaa gtattgctta 645061 aattgtatca agaaatgaca gaacggtagg tgtaaggtgt atggaaaata taattgaaat 645121 taattataac caaactggta aaagtaagaa aacaaatgaa tacggtatgc gtgaaatgca 645181 ggcaagagct tttgaaaaac gtaactcaca atatctctta gttaaagcac cgccagcttc 645241 tgggaaatct agagctttaa tgtttatcgg tttggataag ctcataaatc aaggtttgag 645301 gaaagtgatt gttgctgtac ctgaacgctc tataggttct tcatttaaaa atacggattt 645361 aaaaagttat ggtttctttg aaaattggaa agttgatcct agaaataatt taactgttgg 645421 cggagataac tctaaggtta aatcttttgt tcgttttatg gaatcggacg atcaggtgtt 645481 aatatgtacg cactctactt tgcgatttgc gtttgaaaaa attgatgata aagcatttga 645541 taattgttta cttgcaatag atgaatttca ccatgtatcg gcagatgtca attctcgatt 645601 aggtgaattg ttaagaagta ttattcataa ttcatcagca catattgtag cgatgactgg 645661 gtcgtatttc cgtggagatt ctgtaccaat tttattacca gaagatgagg aattatttga 645721 caaggtaact tattcctatt atgaacaact tgatggatat gaatatctaa agggatttgg 645781 tataggatat cacttctatc aaggccagta cacatcagct attaatgaag tattggatac 645841 aaataagaaa acaatcgttc atattccaaa tgtaaactca ggggaatcga caaaggataa 645901 gtacgatgaa gttggtaaga tacttgatat gattggtgaa gttgaatatc aagatgatga 645961 tactggaatt atttatgtta agcgacattc tgacggtaaa acattgaaaa ttgcagattt 646021 agtagatgac caagttggaa gagaaaatgt cgttgcgtat ttgcgtaata ttgaagccct 646081 agacgattta gatataatta ttgctcttgg tatggcgaaa gagggctttg actggccgtt 646141 ttgtgaacat actttgacag ttggttatcg tggctcactt acagaaatag tacaaataat 646201 tgggcgctgt acacgtgata gttacaataa aacctatgct caatttacca acctaatcgc 646261 aatgcctgat gcaaaggatg aagtagtgac ttatacagtg aatacaatgc ttaaagctat 646321 ttctgcctca cttttgatgg agcaggtcct tacacctgac tttaaattta aacgtagaag 646381 aaatgaaagt gaaaaatctt ctactacagg agaattattc gttaagggat tgaaagaacc 646441 atcaacagaa aatgtcaaaa agattattga aaatgatatt aatgatttaa aagcaaaaat 646501 catgcaagat tcacaagtcc aaaaaacatt tagtggagaa gtagatccca aagtattgaa 646561 caaagtgttg attccgaaag ttattcaaaa agtatatcca aatttatcag atgaggaaat 646621 tgaggaagtt agacagcacg ttgttctaga tacagttatg aaaggtgcta agtctgaagt 646681 tgtaggaagt aaagaattta taagaatggc agataagttt ataaacattg aggatttaga 646741 tatcaatctg attgattcca tcaatccgtt ccaaaaagca tttgaggttc tatcgaaaga 646801 attgaactca ccagtgctaa aactgattca ggaaactatt gatgcaaaac gtattaattt 646861 tgatgaagat gaactagtat tcatatggcc aaaggtttag gaattttatc gttcaactgg 646921 tagaagacct gattcaaaat ctgaagaccc acttgaaagg cgtatgggtg aagctgtatt 646981 atacatgcaa gagcttagga ggaaacgtga aaatggcaag taatagatac cattctatta 647041 atgaaatcat ggaaagtcag ctgttttacc aaatcacaac accacctaag aaaacacaaa 647101 aagcccagta tgatcctgaa gttgaaaagt ttttggagat tattgaattc gtcaaagaaa 647161 atgggcgaga accccaaaaa gtccctactg atttaactga aagaagttta gcaagtcgat 647221 taattgggat tcggaaagat cctgatcgta tggaatattt gaaagagtat gatgaaattg 647281 gattacttga agtaagatcg aaggaactaa caattcctaa aatttcttca attgatgata 647341 ttctaaaaag tggcttatct gcattattag gtgataattt aaataatgat ataactaggt 647401 caatttttga tacaagttca cttcaaaagg ttacgacaat gcctgaatac gttgcaaagc 647461 gtaaaaaaat aaaagatttt ggaaagtttg aagagctatt caagaagtgc cacaaggaaa 647521 ttacagaggg taaacgaaaa attttaactt tcaaaaatga acaagacata cagtcaaata 647581 gtttttatat attaaaagga gttcttcttt atgttgaaga tgtgggagaa cgtaaaaaag 647641 caaagggaaa aaccaatgct agacttcgat gtatatttga aaatggaacg gaatcagata 647701 tgttactacg ttccttatca gcggagttat ataaacatgg tagacgtgtg accgacaatg 647761 aagatacatt gttggataat gttagagaag atgatgtttc gactggcttt atttacgtac 647821 taaaatcttt gagtacagat ccgcaaatta gttccattaa gaatttatat aagatcggtt 647881 ttacaactgg ttcagtagaa aatagaatca ggaatgcaga aaatcaatca acttatcttt 647941 atgctccagt agaaattgta accacatatc aagtgttcaa tatgaatgct agcaaatttg 648001 agacggcaat ccatcatgcg ctagcaaata ataatttgga tgtttctatt ttgggggcaa 648061 atggaaagat gttagttcct aaagagtggt tcgttgtcac acttgaagat ttacaagctg 648121 taatagatga gattgtgatg atggttcatc tttatgacta aattagtata ttaggatttt 648181 agtattaata ataattttat agtagactat gaaaaaattt gatgccataa caataacttg 648241 ttccgctttg gagtttgtca caattgtaga attatgtgtt gcgagtatta ataggaaggg 648301 gttgagcgac cgcaaaaaaa attttcggtg ctgtccgcaa aagggagttt gggtgttttg 648361 cgttatattt ggttgtgtga aggttagcgg aaactcaatt cgtgaagtta ggattgcggt 648421 tattacgact gagtagtttc gtcatactct tttagcagtt tttctgtctt atgcatttct 648481 ttgagcatcg gattcatgta gtcgttagct gattctagat atgctctcgt cagagtgtct 648541 agtttatttc taactttaga gaggtcttct tcgaattttc catccgatga ttgaaggata 648601 aattcttttg cctcttcata tctttttaat atgtttttca ccattggagt tggattcttt 648661 tgatttattg tttttattac agtgattgtt aaatttattt gttttattaa ttcttttctt 648721 actgtcaagg tgatgctcct tttaaatctc tattctattt gagagttgct atatctgttt 648781 aatggtttga tagactactc atctttataa tttagagcaa tttttacaac ttgttccgct 648841 gtgtaatctt cattgctcca gaaaattaaa tcacttggtg ccggataagg aacatttttc 648901 tctaataaat cgagatattc actgactttc tcatcatcta atgttgggtt cattaattcc 648961 tttacaagaa agatcaactc ttcttttgtc agtttatcca ttgtttgccc tccaatagat 649021 tgtatctcca ttgattttac aaatgacttt atttcttctg ataatgttat aggttgtttg 649081 cataatgata gataattgtc ttgagaaaag ttagtctcat tatagagttt attaattgta 649141 tttataacaa tatattcata tggaaaacct ctaaaatatc tttattttag attggtttat 649201 aaaaaatagc tcagcagagt agggctgagc cattttttaa ttatagaccg aggtaactaa 649261 ttacaaattc tttatcatcc tcatcttcag gcaaaatacc aaggttttta tattcccata 649321 ttgcgattct ttcatatcca tctaattctg aggctaaaat atcatcataa ttataatcta 649381 attggaattc tccgctacga tccaatgtta gtgtaaggtt agtccaaaca tcatcgttat 649441 tatttctgtg ttcagttctt aattcttcaa aaagttctct tagttctctt aacaacgtct 649501 tgaaaatatc cttgcttacg ttgtaatggc taggtatatc ttgtgaataa ataatttgat 649561 tattttctgg tgttctgaaa tgaaaaagaa ccattgtgga atcatctaat acttctgcat 649621 aaagatatat ctttgtccat tcaccaggta tgatgtcatt gagtttttct ccaataagtt 649681 gatacaaatc ttgcatcttc ctagtttcca ttcttctaac ccccaggctg atttttaata 649741 gagacgctta tttcttttct gctcccaatt ttgtaggtta catcgaaata tgatggtcta 649801 agtgaatccc cagaatagac tggttctatt tgaactgcta cttttttagg tggttttttg 649861 cttagggctt ttgcccactc ctgctccatc tcataccatt tcccaccgct cctattaatc 649921 tgagaattca tcggcacgat attgtcaaac tggcctgagc ctttgaattg ggtggcgatt 649981 aaatggccgc cgtcatcgtc aggctttcgg tcctggggct ttccagcatt cgtttgtgca 650041 tattggtttc gtttcgcttc tcccagctgc aagtctgctt tgacacttgt aattctacca 650101 tagttgtcag tcgtgtacgt gtagccttct tttgttttgt agatgatatt aggcttcagc 650161 actttctttc tgctccatct tgcgaaatgc tcgccgtatt tgacggttac cggcggtaca 650221 tgtggcgctg gagttcgtct tccgcttgat gacgttccgt atggtttcgg caggatgacc 650281 ttggcgaatt tttgcagtcc ttctttaagc gtgaccccgt tgactgcgtt gtaaggaacg 650341 cctgccggca ctaaatcatg acggggatga tacgggagaa tatccgcaag tgtgagatct 650401 ccgatttgat ttaacttggt tttgacgtgt ttttttgata cttcaatgcc tgtgtttact 650461 ttttgtttga tgtgatcaac ggtttgtttt gagactgtta tggctttttg ggctgttgct 650521 gatttgcttg ctgctgtttt gactttggtc gtcactttgg cggctgtgcc agtttttgag 650581 acggctccta cgccttttgt gccgacaatt gatgtgacaa cagtgccaac cgcatatgac 650641 acccatcttg ctcttgagta ggtgtcacca ttcaccatgt ctttttgata cgattcttcg 650701 attgccgctg aaatggcttc atacgttttg atcgggtgag ccatcgctcc ggtaatcgct 650761 tcaacggttc ctcccggatc tgtgaccata tcccacaggc ctacgaccgc gtctttcccg 650821 gaatcataaa ggccgacggc aacccctttg aagcctgctt caagctcacg cgtgttttca 650881 atttgggtga agtatctctg ttgttcagct gtcagatttt catagccgat cgtttttgcc 650941 atttcgtaga attcatcggc atctgcataa tcgtagtttt tcagtctttc tttcagtttc 651001 tcaatctcgc gttccttcgc ttcctctttc ttaatcttca agtaagcctc agtccgcttt 651061 tcaatgtcgc cttttttctt atgtatgtca ctctcacggt acgccttggc gttgtagtgg 651121 atgggtgtgg cgtttttgcc tttacccgtt gcttcttgga gcttttggaa gtcggatttg 651181 atgaattgtt cgtttggttc agacagggcg tattctgttt tcaggtcttc gtccaaggcg 651241 tccaattttt ccagtgtttt tttgcgtttg tcgttggcat cggccagctc gtctttgaag 651301 gtttctgttg aaaacaggtc gagcgggagg atgtcgtcga tatcgtttag gatgtctttc 651361 atcgcttttt tctgttcgga catgatggat ttagattttt tattggcatt tgccagttcg 651421 tgctccagga aggattcttc gatgtatgcg tctgagaggc ctttgtcttc ggcggctccg 651481 gcgatgctgt tgaaaaatgc gattttcatg tcgatgtagt cgatccactg gtcggcgacg 651541 ccgacgtggt cgtgatagaa tgccttgatg ttgctggcgc cttttcctga gaattcactg 651601 tcactgagat cagcgactcc ttttaacgct tttctcaagt tgaccatttg cgttcttagt 651661 tctttgtact cttttgcacg gtctgtcgct tccgaaagca gtgttttcgc ttcaaatact 651721 ttcatgacca tttcccttct tttgttcgct caatatcaaa attttaccac gggtcgggat 651781 aaggtggggg tgagaacgtg ttttggtgga aaaatgagtc atttggcatg tgtctttatt 651841 cgtggaggga ttggaggaaa catggtcgaa atgatattga ttgctacaca ttttttggaa 651901 gtttgtattc tatattgttt tttaaggagc atgttgatga cgaaaaaacg gattacattt 651961 ggtttattag ttttaatggt atgtgtcatc ctgtttgttc tgtatgttca gttacgcaat 652021 aaagatagta ttcctgtcca atcttccgcc attcaccccg aagaagaccg catctttttt 652081 atttactcca atcctttcat aaaagaaagc gtgctgcttt caacctctac aggcgaacgg 652141 tttaacaggc gtacgtttaa ggtggcggat gtgccttata ttcaaacgaa atcttatgca 652201 tcaacagacc ttgtattatt ggcggaacac gagccttttt actacacgct ggagaaggat 652261 gtgatcaaag agcatccgct gtcagatcca tttgcgtttt ggtatgaggg gaaggatgtc 652321 actattgagg cctataatgt tgatacgacg ggaaatgaga tccacataaa cgacagaaaa 652381 acgaaaaagg aatataccct taccttgcct ccgcttgtca caatgggggc cagtgatgag 652441 aactttattt atatcattca aagcatgtct atttacgtga ttgacagaaa aacagaggaa 652501 atgattgaga ccctgagctt agcctcatac gctgatcaat tcgcagactc ggaggaattt 652561 atcgtcgcga gctcggatca taaattgact gtgattgaaa aagggacatg gaagacgaca 652621 tatattgcgt atcctgaaga tcttgaatat gcagatactg tgtactatga caaagaaagc 652681 ggcagttttt acgtggcgta cgaggacaaa gagggtggag cgaacttgct ggaatatggg 652741 gaggattttt ctattcacac atacagcttg aaattccctt atatggaggc gaagtttaag 652801 gggaatctat tgtatatagt tgcccaggaa gagcataaaa agggcatcgg cggatacgtg 652861 ggtgtgtttg atatccattc taaggagatg ctttatcagt ttgatttgcc tgaggaacag 652921 gtgaaggttc aggattttgt tgtggttgac aataagtgaa tactatatga aatagaatga 652981 caaagaccct tgcataaagg gttctttttt atgaaaaaaa caaattgaca ggatgaaaaa 653041 acaatttctt ccttctatat tgttttcaaa atttgggatt gatagaatat gacatatctc 653101 atagagaagg agggaagccg ttgagtcaag ccataccgtc ttcgcgtgtt ggtgttaaga 653161 ttaatgaatg gtataaaatg attcgccagt tcagtgttcc ggatgctgag attctgaaag 653221 cggaggttga gcaggacatt cagcagatgg aagaagatca ggatttactg atctattatt 653281 ctctgatgtg ttttcggcac cagctgatgc ttgattattt ggagccggga aaaacatacg 653341 ggaatcgccc tacagtgaca gagcttcttg aaacgatcga gacccctcag aaaaaactca 653401 caggtctttt gaaatactac tctttgtttt tccgcggcat gtatgaattt gaccaaaaag 653461 aatatgtgga agcgatcgga tattatcgcg aggcggagaa agaactgccg tttgtgtcag 653521 atgatattga gaaagcggaa ttccatttta aagtggcaga agcgtattat cacatgaagc 653581 aaacccatgt gtcgatgtat catattcttc aagccttgga catttatcaa aaccatcctc 653641 tatacagcat tagaacgata caaagcttgt ttgtgatcgc cggcaactat gatgatttca 653701 aacattatga taaagcgctc ccgcatttag aggcggcgct ggaattggca atggacattc 653761 aaaatgacag gtttatcgcc atttctctat tgaacattgc aaacagctat gacagatcag 653821 gagacgatca gatggctgta gaacatttcc aaaaagcggc gaaagtaagc agagagaaag 653881 tgcctgatct gcttccgaaa gtcttgtttg gattaagctg gacattatgt aaagcgggcc 653941 aaacacagaa ggcgtttcag ttcatagagg aaggattaga ccatatcaca gcacgttctc 654001 acaaatttta taaagaattg tttctgttct tgcaggccgt gtacaaggag actgttgatg 654061 aacgaaaaat tcatgatctt ttaagctatt tcgaaaaaaa gaacctgcac gcttacattg 654121 aagcatgtgc ccggagtgct gccgctgttt ttgaaagcag ctgtcacttt gaacaagcag 654181 ctgcgtttta tcggaaagtg ctgaaagccc aagaagatat tctaaaagga gagtgtttat 654241 atgcctatta agaaaaaagt gatgatgtgt ctggctgtta ctctagtttt cggaagcatg 654301 tcgtttccaa ccctgacaaa ctccggtgga tttaaggaat cgacagatcg aaatacgacg 654361 tatatcgatc attcccctta caaacttagt gatcagaaga aagcccttag ctagggcttt 654421 ttcttgcttt acggaagacg ttccattttc cacatcgcgg cattccttct atttctaacg 654481 caagacactc gaaacaacca aaccatttga ggtataatgg ataaagtgaa taacagtatt 654541 tagattgata tatatgaaag agagtggaac atcatgggcc gtaagtggaa caatattaaa 654601 gagaagaagg cgtctaagga cgcaaatacg agtcggattt atgcgaagtt tggccgtgag 654661 atttatgtgg cggcgaaaca gggcgagcct gatccggaat ccaaccaggc gctgaaggtt 654721 gtgcttgaac gtgcgaagac ttacagcgtg ccgaaaaaca tcattgaacg tgcgatcgag 654781 aaggcgaagg gcggagcgga agagaattac gatgagcttc gttatgaggg cttcgggccg 654841 aacggatcaa tgattatcgt tgatgcgctg acgaataatg taaaccgtac ggcgccggaa 654901 gtgcgtgcgg cgttcgggaa aaacggcgga aacatgggtg tgagcggatc tgttgcttac 654961 atgtttgacg cgacggctgt aatcggtgtg gaaggcaaaa cggctgacga agcgcttgaa 655021 atcctgatgg aagcggatgt tgatgtacgt gacattttag aagaggatga cagcgcgatc 655081 gtgtatgccg agcctgatca attccatgcg gtgcaagagg cgtttaaaaa cgcgggtgtc 655141 gaggaattta cagtagcgga gctgacaatg cttgcgcaaa gtgaagtaac gcttccggat 655201 gatgcaaagg aacagtttga aaaattgatt gatgcattag aagatttgga agatgttcag 655261 caggtatatc ataacgttga tttaggtgag taaggagtga gcaggctgtt atggcctgct 655321 ttttttgtcc cggaaattgt tttagctgta tgtaggcggc cgcctatacg atctataaga 655381 tattctcata ctctggactg taacctatgt gaaggagaga gtaaatatga ctgatacaag 655441 acatatgtat ggcggacctg gttttggtca ttatcagggc tttggtattg gccacccggg 655501 ctatggcatg caaagcacag gctatccggg ctatggcatg tatggaggcc acccgggcta 655561 tggcatgcaa ggctacccag atcacggcat acatggagga gtcggcggct atccgggata 655621 tggtgggtac ggcggttacc caagcggcgg ctatggaggc tctccgggaa ctggaagcta 655681 tccgagcatg caccatgaaa atgatggcca tcaccactat tatcaccatc atcatgatgg 655741 aaaagataat cttcatcacc atcatcacca tgttggaaag gataatcatc accaccatca 655801 tgatggtcat tatggccacc atcatcacca tatgggccac tggggaaaag acggttataa 655861 ataaagaaga tgatgataaa aagaggacac tcttgcagat caagagtgtt tttttagctt 655921 ttttcttgac tgttcagtct ggaaaatggt aacatttgtt tcaggaggtg atcatttttt 655981 ggggaggaat aaagaatttg atacggcgct tgttcttcac agggcgatag aggtttttgg 656041 agagtatggc tacgaaggaa cgtctcttca ggatctgctc tctcatttag gcattgcgcg 656101 ccaaagtttg tatgatacgt atggaacgaa gcgtgatttg tttttgtccg ctgtgaaatc 656161 gtatcttgaa gggaaaaacg ctgccgttat ggaaaggctt gaagcgccag gatctgtaaa 656221 ggaagccatt cgtgatattt ttcaggaggg tgtcaatgcc ctgagggatc cggaacgggc 656281 gaaggcgtgc tacattatta acagcgcgat tgaacagatc ccgcatgacc ctgagcttgc 656341 ccggtatttt gaaagacaat ccaagcagct tgaggacgct ttttatcacg ggcttttaag 656401 agcgaaggat caaggagaat tgaatggcga agatactgat atatctgcgc ttgctcggta 656461 cctgaatcag agcaggctgt cactgacatt tattgcaaaa gtgacggcag atatggatcg 656521 gcttcaggac catgttgacg tgagtttatc agtgcttgat taacatgtgg taaaggattc 656581 tttgcccatg tatgtacttt ttggactgaa tagtctagaa ataaaaatga ggtgatgatg 656641 aatgttgatg aatgagtttg aaaaagcatg tgaaacattg agaaagttta tggcttatat 656701 gcttgagaag gacatgaaga gctggacgga gctttgggat gagaatgctg tatttgagtt 656761 tccttatgcg ccggagggat caccaaaaag aatagaagga aaagcggcca tttacgatta 656821 tattaaagat tatcctaagc agattcatct ttcttcattt accgctccga cagtgtaccg 656881 ttcagcagac tcgaatacgg tgattgcgga gtttcaatgt gacggccatg tgattgagac 656941 tggactgcct tatcgccaaa gctatatcag tgtcatcgaa acgagagacg gccgcattgt 657001 gcgttatagg gattattgga atccgcttgt tgtaaaagag gcctttggag gatcattttt 657061 gcaaacagag gagagtggga aatgatgaaa cagaatccga ttttaatcac gggcgggacc 657121 ggcacagtcg gcagccgaat cgccagccgt ttaataaagc tgggatacag agtgcgtatt 657181 gcaagccgga aaaagggcgc gcttgctgat gctgagtatg tgtattttaa ttggaagtac 657241 gcctccagtt ttacgcctgc tctggaacag gtaaaacaga tctatcttgt tgctccggtc 657301 ggtgtatttg atccggctcc ctatgtgctt ccctttttaa aggaagcaaa gcgtctcggc 657361 gcaaagcggg tagtgatgca aagtgcgtct gttgtctccg agaacggtcc cgtgtttggc 657421 gcgcttcacc aggcagtgcg cgagtttcca gaatggacgg tgctgcggcc ctcatacttt 657481 atgcaaaatt tcatcaatgt ccagcaccgc atgtctattc aaacggaggg gcgcatcaca 657541 acggcttcgg gtgaaggaaa acttgggttt attgacgctg atgacatcgc agaaacagcc 657601 gtcagggctt tgattgatga tgttcctcat caaacacatc atattctgac aggtcccgag 657661 gcgctgagct atgccgaagc ggcggagatc attggagctg cggcgggacg ccgggtggag 657721 catgtcagca tttctcgttc cgagctgcag cataaaatgg aggcaggagg tttgcccgcg 657781 gattatgccc attttatggc gaagcttgat gaggcaatta gccatggtgc ggaacatcgg 657841 gtaacggata cagtgaagcg tgtgacggga aaagaacctc gttcgctgtc agagtttgcg 657901 gctgctcatg ctgcatattg gacctcattt tggactgaat agtctagaaa gaccttcggc 657961 gcttccgaag gtcttcttat tgaaaaagct aagtcgtgtt ttagtcataa tcatgcctcc 658021 tgcctcatac ctattaaggt cattgttttt gagaaaggag gagccggaat gaaggatatg 658081 cagccgttta cgcctgtcaa atcatatacg ccctttcaca gccgttttga tccctgtccg 658141 cccataggga agaaatatta cagaacgccc cctaaccttt atatgacctt tcagcctgag 658201 cacatggagc agttttcgcc gatggaggct ttgaggaaag gcaccctttg gaaggatctc 658261 tatgattttt atgaaaaccc ttatcgaggg ggagacgcac atggcaaaaa aggttgacgc 658321 cgaatattat cgtcagctag agcaaataca ggctgctgat tttgtgcttg ttgagctgag 658381 tctttattta aatacacatc ctcatgatga agatgcgttg aagcaattca atcaatattc 658441 cggctattca aggcacttaa aaagacagtt cgaatcctct tacggaccgc ttctgcagtt 658501 cggcaacagc cccgcgggca aggattggga ttggggaaaa gggccatggc cgtggcaagt 658561 ataaggagga atgcctgaat gtgggtgtat gaaaagaagc tgcaataccc tgtcaaggtc 658621 agtacgtgca acccgacgct ggcgaagtat ttgattgagc agtatggcgg agcggacggc 658681 gagctggccg cggctctccg gtatttgaac cagcgttata cgattcctga taaggtcatc 658741 ggccttttaa cagatatcgg cacggaggag tttgcccatt tggaaatgat tgcgaccatg 658801 gtctataagt taacgaaaga cgccacaccg gagcagctgc gtgaagctgg gcttggcgat 658861 cattacgtca atcacgacag cgcgcttttt tatcataatg cggcgggcgt gccgtttacc 658921 gcgagctata tccaagcgaa gggcgatccg attgccgatt tatacgaaga tattgccgca 658981 gaagaaaagg cgcgggcgac gtatcaatgg ctgattgata tttcggatga tcctgattta 659041 aacgattccc tgcgtttttt gcgtgagcgt gaaatcgtac actctatgcg cttcagagaa 659101 gcggttgaaa ttttaaaaga agaacgggat aaaaagaaga ttttctaata ggcagattgg 659161 cctctctttc atacaccctt ttacatacag agaaaatggt ctgtttttgc agtttggtct 659221 gcattataat caaggtgtgt gtgcaagctt actttttgat tgggaggcct ttatgacagc 659281 ttttaagatt gagaacgaaa cgattgcaga tggattttac gcgtgtccgg ccgtctatga 659341 ggatgcagaa tcgattaccg ggttgctcgt ccgaacagct gaatggctcc gggatcgggg 659401 ttctaaccaa tggagcggac ttctcaaagg gcaagatata catgatatca cggggtcaat 659461 tgaaaaggga catgtgtttg tgtttaaaaa agatgaagag cttgcggctg tcgtgatgct 659521 gctgcctgca ccgagcgagt gggaccggac gctttgggga gacgatgggc atgaggagtc 659581 catttattta caccgcctcg cagtaagccg ccggtttgcg ggacaggggc ttggagcccg 659641 cgtccttcag tgggcggaga cgggcataca ctttccggaa aaaacgcgga tccggcttga 659701 ctgtgtcgct gatagtgacg ccctgcattc cttttatcgg cgtatgggat atgaattcat 659761 gggtgctgat gcgtccggat atcatttgtt tgagaaagag attacggcag aataagcgtc 659821 ctttgcaggg ggcttttttg tctttttcta aaagggaggc aggcgatgtg tggtcaatat 659881 tatttgtgac agggattgtg acggcttgtc tgtttgctgg cgtatccgta ttgatgcgga 659941 tgagatttcc tgacaaaagt cggccggaat ggatgttggc cgggctgatc gtccttggtg 660001 tgtttgcgat ctggtacagc ctcgtgtatg tacgcggctg ggaaggggct gcgctcggaa 660061 tgcttggatt caatgtcatt ttcggagcca ttgccggata tttgatcgat aaggccatcc 660121 ggcgttacag gaaaagataa ggctgctgcc gtctctcaac aggtcgaaat tttcacagac 660181 cggcaggaat tttctttcga aaggagaaat acatattact ttaaaatgaa agcgttttcc 660241 aaagcaggaa ggtgatgttg atgatacaca gtgtggcaaa tgggctgaat catttttgta 660301 cgtgggtgat gagactggcc tatttgaatg tgctttggat tttgttttct cttgcaggcc 660361 tggttgtatt tgggctgatg cccgctactg ccgcgatgtt tacagtggcg agagaatggg 660421 cgaaggggaa tacagatgcc ccggtgtttt ctgtcttttt tcggacgttt aaaaaggaat 660481 ggcgggcatc acagatcctc gggcttatcg ttgtgacggc tgccctgttt ctgtttgcgg 660541 atatgcggat agcggctcag atggaccagc ctgtgctcgt caatgtattc gtgagcatta 660601 gtttgatttt cgcgtttgtt gtgctgtatg tgttcccggt attttctcat tttgacgtaa 660661 aaatcagaga ggtgctgagc atcagctttt tcattgcctt cagtcgtccg gcggtgacgc 660721 ttttgatggc agcgggcgct gtcggtgtgc tttgtctcgt tctgtttcat gtcacgtttc 660781 tattgttttt cagcgggagt ttactcagcc tgatcttaac gaagctgtcc tttaaagcgt 660841 ttcggtcaat ggatcagcgg caggagaaag aaaaggcggc atgaagaaaa gagttgctgg 660901 ctggtacagg cggatgaaga ttaaggataa gctgtttgtg tttctatcgt tgattatggc 660961 cgtatccttt ctgtttgtat acagcggggt ccagtatgcc tttcatgtgt atgatgagca 661021 gatttaccgc aagtcctcgg aggtgcttcg gatgtcttct gaaaggatcg aagacgagct 661081 gaagaagata gaggatgtgt catatgaaat cattacagac gaacagattc agcgcatcct 661141 gagcatgcaa aatcgggatg atacgtatga tcaatatcaa atgaagcagg agctgtggga 661201 tcagcttgcg ggatatgcca gcgatgaaaa gtacatcgat tccattcatg tgattgatgc 661261 ccgcggctca gagtattcag ccggaagcag ttcttcagat cttttgcagc aggagcagga 661321 agaggtattt aagcgagcga aagcgaaaag tggaagaaat ctttggatga cgctcggcgg 661381 gtcagacccc gtcctgattt cagcacggca gatcaggtcc tatcaccagc tgagtctgaa 661441 cggcttgggc atggtactga tccaggtcaa tgtaaaacag atgattcgtg atgtgccgaa 661501 ggattggggc gattcagtcg gagacattat gattgctgac caaggcggta atttggtgta 661561 tacggcacat gcatcagcgc atgttcctga ggcagcaaaa gagacgttga agcaccccgg 661621 ttatgacttg ataaaaaaga atggcaaacg ttactttatt tcttatcttc aatcatccta 661681 ccaaaattgg agctactata acgttatccc ctttgatcag atgttcgcaa aaatttcctt 661741 tatgaaaaca gtgatcggca catgctttct tctctttttc tgtgtggttt tgcttttcgg 661801 aaggaaaatc gccaacagca tcacggagcc gattgaacag cttgtgaccg cgatgaaatc 661861 ggtacagcac agcggcattg aagcaggtgt gtcgctttct ctgccggaac atacacagga 661921 tgaggccggc atgctgaacc gccattttac tgtcatgatg aaacggatta atgagctgat 661981 ggaagaaaat gtggaaaaac agctcatcat taaagaaacc gaattgaaag cactgcaagc 662041 ccagatcaat ccgcattttt tatataacac gctcgagtcc atcaattggc tggccaaggc 662101 gaatcagcaa aagcaaatct caaaaatggt ggaatcgctc ggttttcttc tgcgaaacag 662161 catacatatg aagaaggata tcgtgaccat tcaggaggag gcggacattg tacgtcacta 662221 tatgaccatt cagcgatttc gatttgaaga gcgcctgaaa ttcacgttgg atattgacga 662281 tgaggtgaag cattgcctca ttccgaaact gacgctccag ccgcttgcgg aaaatgcgat 662341 tcaatacgcg cttgaaccct ttacaaggcc atgcgccatc cggattcagg cgaaaaaggc 662401 gaagggctgt gtctgtatta cggtcgaaga taacggccct ggcatggatg gacggattct 662461 tgaatcaacg ggtggaagag gaatcggact ttggaatatt cgcgagcgca tcagcctgac 662521 attcggagag ccatacggat tgcggattca tagtgagcat gaaaagggga cgaggattgt 662581 gatcacaata ccgtgccgaa atgaggtggt gtgatgtata aaatactgct ggctgatgat 662641 gagaggatta tccttgatgg aatggcggga atcattgagt gggagtcgct tggcgcctca 662701 ttgatcggaa aagcgcagaa cggacatgaa gcatatgaaa agattgtaca taagcagccg 662761 catatcgtca tcacagacgt caaaatgccc ggcatggacg ggcttgagct gatcaaaaag 662821 gtgtcagccg tcagcccgtc ggtgcaattt atcgtcctgt ccgggtttgg agagtttgag 662881 tacgcaaagg aagccatgaa atatggggtg aagcattatt tgctgaaacc ctgcaatgaa 662941 cagcagatta tcagctcgct ggaggaaatc attgctgagc tgaagcggca agatgtgcac 663001 aaaaagaaaa cagcccatct gaaacacgag ctggaccata tccgttcctt tgcagccgat 663061 caatacttgg aaggcttgat cgccggtgtg gcccagcttt ctccgccgcc ttcacttgcc 663121 ggaaaaaaga tccgcctctt gatcttaaaa ggggaacaat ctattgatgc tgcagccaga 663181 gaggcactcg gatcggcact gacagcggtt tgcagcagcg gtgaatggac cgtgctcgcc 663241 gtagaggaga acgccgctga aaaggtggcg gaggtttttg cggaccgcaa gatggccatc 663301 agtcaggcgg gagaactccg gcacgcgggg cagctgtttc gtgacacagc tgaagcgtct 663361 ggtgacctgc atgggagcgc agtgatttca aaaatgatca ggcttattgc cgacgagctc 663421 ggaaatccga atctgtcctt aaaatgggcg gcgaaggata tgctgtttat gaatcctgat 663481 tatctcggga agttatttaa gcaggaaaca ggcgagaaat tttcccaata tgttacacgg 663541 gtgcgtcttg agcatgcgat gaagcagatg aaaataagga gggacgtgag cgtttcagaa 663601 attgctgaag aaatcgggtt tggcgataat ccgaagtatt tcagtcttgt ttttaaaaaa 663661 tataccggtc tgacaccgtc agaattcaga agaaaacagg gaggcgcttc cgcaggatag 663721 ccatctctgt ttttttgact ttcgccactg ttttttgagt gtttcgccct atccgaacgc 663781 tttaaaataa aatgtaagca cttacattaa aggggggatt ggtttgaaga agatttgtta 663841 cgtgctgtta tcccttgtct gcgtcttttt gttcagcgga tgttcagcgg gtgaagaggc 663901 ctcgggaaaa aaagaagatg ttacactcag aatcgcgtgg tggggcgggc agccaaggca 663961 tgattataca actaaggtaa ttgaactata cgagaaaaag aatccgcacg tccatattga 664021 agcggaattt gcgaactggg atgactactg gaaaaagctt gcgcccatgt ctgccgccgg 664081 ccagcttcct gatgtcattc aaatggatac cgcttactta gcccaatacg gaaagaagaa 664141 ccagctggaa gatttaacgc cgtatacaaa ggatggaacg attgacgtca gttcaatcga 664201 cgagaatatg ctgtcgggcg gaaaaatcga caataagctt tatggattta cgctaggtgt 664261 caacgtgctg tctgtgattg ccaatgaaga tttgctgaaa aaagccggtg tgtctatcaa 664321 tcaggaaaac tggacgtggg aggattacga gaagctggcg tatgatcttc aggaaaaagc 664381 cggtgtctac ggttccaacg gaatgcatcc gcctgatatt ttcttccctt attatttgcg 664441 cacaaagggt gagcgctttt ataaagaaga cggcactggc ctcgcgtatc aagatgatca 664501 gctgtttgtc gattactttg aacggcagct gaggctagtg aaagcgaaaa cgtccccaac 664561 acctgatgaa agcgcacaga ttaaagggat ggaagacgat tttatcgtca aaggcaaatc 664621 agcgattaca tggaactact ccaatcaata tttgggcttt gcccggctga cagactcgcc 664681 gctgtctctc tatctgccgc cggagcaaat gcaggaaaag gcgctgacac tgaagcccag 664741 tatgctgttt tccattccga aaagctctga gcataaaaaa gaggcagcga aatttattaa 664801 tttcttcgtg aataatgagg aagcgaacca gctgattaaa ggcgagcgag gcgttccagt 664861 ctccgacaag gtggcggatg cgattaaacc gaagctgaat gaggaagaaa ccaacatcgt 664921 ggagtatgta gaaaccgcgt caaaaaacat cagcaaagcc gatccgccag agcctgtggg 664981 aagcgcggag gtcatcaagc tgctgaaaga tacgtcagat cagattctgt atcagaaggt 665041 atcgccggaa aaagccgcca aaacgttccg gaaaaaggcc aatgagatat tagagaggaa 665101 taattgacgg gaaatggggc tgacgcaatg aaaaaaagcc ggagtataag aaaagacaat 665161 ctggcgggat atgcttttat ttctccgttt atcatcgggt tcctatgctt tacggtgatt 665221 ccgatggggg cgtccctgtt tctgtccttc acgagctatg acttgtttac ggcgccgaaa 665281 tggatcgggc tcgacaactt taaggaaatg tttacgggtg acgaaaagta ttggcagtct 665341 ctgaaggtga cgtttacgta tgtgcttgcc ggggttccgc tccgcctcgg cttcgcgctt 665401 tttatcgctg tcattttaaa caatgcagca aaaggaacgg ccatttacag aacgctcttt 665461 tatctgcctt cgatcatcgg cgggagcgtc gccgtggcga ttatgtggcg caatattttt 665521 ggcaatgacg gggtcatcaa tgcgctgctg ttttttgtcg ggattgatca aaaaattctt 665581 tggtaccaga atccgacaag tgcgctgtgg acattgattc tgctgtccgt ctggcagttc 665641 gggtcgtcaa tgctgatttt tttggccggg ctgaaaaaca ttccgtcttc gtatttggaa 665701 gcggcaagtg tggatggggc aaatcgggtg cagcgtttct tcaagatcac gcttccgatc 665761 cttacaccga ttattttctt taacctagtg atgcagacga tttctgcttt tatgacattt 665821 acacctgcct atatcatttc gaagggcgag ggcgggccgc ttgacgggac acttctctat 665881 tcgctctatt tgttccagcg tgcgtttaac tattttcaaa tgggctacgc atcggcgatg 665941 gcgtgggtca tgcttgtcat tgtcgggctg attacgctca tattgtttaa aacatcgtca 666001 tattgggttc attacgagtc aaaggaggaa tgacggatgg agccggtcaa ccagcctgtc 666061 agagaagccc cggtttttga gagaaaaaaa gccgggcgcg tcagtcccaa acgcatactg 666121 ttccatgttt ttacggcaac gctggcggtg ttgctgctgt acccggttat ttggctgttt 666181 gtcagctcgt ttaaagaaag cgccagtatt tttacaacct cacattctct cattccagac 666241 ccttttattc tcagtaacta tgctgaaggg tggaagggca ttgcgggaca gccgtttctg 666301 acgtttatta aaaactcggc gattattgtc gggctgtcaa caatcggtgc cgtcatgtca 666361 tcggctgtca ttgcgtacgg atttgcgcgt ataccgttta agggaaaaaa attttggttt 666421 gcgtgcatga tggggacgtt aatgctgcct catgaagtgt tgatgattcc gcagtatatt 666481 atgtttgcga aattagactg gctgaattcc tttaaaccaa ttgtcgttcc gcaatttttc 666541 gggcatgcgt tttttatctt tctgatgatc cagtttatcc ggacgattcc cgaggagctg 666601 gatgaagccg cgcgaatcga cggatgcgga cgctttgcct gcttttggcg gatcattctc 666661 ccgctgattg cccccgcgct tgcgacgtct gcgattttct ccttctattg gaagtgggag 666721 gagctgattc agccgctctt gtatttgaat aagccggagc tttaccctgt ttcacttgcg 666781 ctgaagcttt ttctcgatac agagtcggct tcgaactggg gcgcgatgtt tgccatgtca 666841 gccgtctcgt tattgcctgt gattcttgtt ttctttttgt ttcagaaata tatcgttcag 666901 ggcatcagta cgaccggatt aaaataaaaa ggagtgttgc agatggcaca gcttatcttt 666961 gatgaagaaa aggtgacgtc ggttattgac cggatcgtga aacggacatt tcagatggat 667021 tttgcgtggg attggccggg cggcgttgcg ttttacggtg tggcggaggc ctatgaagcg 667081 acggaaaacg aggaatatat caatctgtta aaaacgtggg tggatgaaca gctggaggat 667141 gggctgccgc cgctttcgat caacggagtt tccattgggc atacgctttt gttcctccac 667201 aaggtgacag gtgatgacgt gtatttggaa acagcggccg agatggcgga atatgtgctg 667261 cataaggcgc cgcgctttgg cgagggtatc cttcagcata cggtgaatgc ggcagaatac 667321 gtattccctg aacaggcatg ggcggatacg ctgatgatgg ctgggctgtt tatgctgaga 667381 atcgggcggg tcatggagcg tgaggattat tttgaagacg gcctgcgcca gtttcacgga 667441 catgaggatg tgcttcagga ccctgtcacg aatttgtact accacgcctg ggacaacaaa 667501 gcgcaaaatc atctgtcggg gatttattgg ggcagggcga acggctgggc ggcactcacg 667561 atggcaaagg cgctcccgct tattgaggtg acacatcctt cctttatgat catcgacgga 667621 tcgctcagag accagctgag cgcgcttgtc cggcttcagg atgaatcagg gctgtggcat 667681 acaattttgg atgatccgga ttcttatctg gaggtttcgg catcagcggg tattgcttct 667741 gctctgatgt cgagcggaaa gctgtataca aaatatgtgc agaaatcgct tgccgccatt 667801 ttggatgcag tggaagagga cggacgggtc agcagggtat cggccgggac agccgtcatg 667861 aaaaatgccg aaggatacaa acaggtgcct tacaaacgaa tacaaggatg ggggcaggga 667921 cttgcgctga cgtttcttgc tgatgttttg aaaacgaaaa aacgcttgta tcagtaaaga 667981 tagcggcggg gggagaggga tgaaaaaaca gcctcaacag aaggaacggg tttctcgctg 668041 gaagggaacg tatttcaaaa gaaactttgt cttcattttg ctgattgcct gtattcccgg 668101 attgctgact ggcggcgcaa tctactttct ttcgatcgac aaggtggaga aagagctgca 668161 gagatcgcat gaaacacagg tggcgcgtga ggtcagccga atggatgaga agctgggagt 668221 gcttgaactg gcactcaccc agatggccta cgattcttca ctgatgaacg gattggccga 668281 gagggatttg gagaaagact ttacgttctc ctatcaatta acgaaaaagc tgtttctttt 668341 gcgggatcag cagccgctga tcgagcaggc ttccatcttt ctgaacagcc cccggccact 668401 tgtgctgagc cctgaataca gcgctttgac agaacaggag gcgcttcgca agtatcgctc 668461 gctgcttgcc tcagaccaca gcatttattg gaaacggtcg ggaaaccaag cgatgctgat 668521 ccagctcatt ccgggcgcgg cggagaaacc gttcggcgcg atcatgctgg cggttgatcc 668581 gaaagaaatg gaatcaatcc tgcaaagctt gtccccctat cctgatggca gtgcgttgct 668641 tttagatcaa aatcgagagg tgctgtttca tgagggggaa aaagattttg aaaagacttt 668701 acttcatgag ataaaaaaac agcctgctga gaacggccat tttcagatgg aatggaaagg 668761 caaggtgtat tctgtctcct ttggagaaat gaaccggatg catcagcaat ggacctttgt 668821 gtcagcggcg cctctttcag ctattacagc gccgatggtg tttttatcaa aagtgatcat 668881 cgtgatgctg gtcatttgca tcggtttggc ggtgtgcatg acatggtatg catcaaaaaa 668941 aatctatcgt cccatccagc atttgcttgg cttgtttacc ggaggagaga agaaaacatg 669001 gcaggcgtcc gggcaggatg aattcaaatg gattgaaaag agatggcagg atctatccct 669061 tgaaagccgg aagctccaac agcagctcct gcggcagacg ccccatatga aaaagagttt 669121 tttgcagcat ctcttacaga gcgattttta ctatgacaac gaggaaagcc tcagatttcg 669181 gatggaggag gctggctgga acatcggcgg aaacgtgttt catgtgcttg atctacaggt 669241 gacagggctc cgctgtgaaa aaagcatctt ccgtgaaggt gatgaacagc ttgccgtgtt 669301 tacactgact aatatcgctg aggaattggc ggctaaacgc gtttttcagc tctccatact 669361 tgatatcggc cggctttctg tcaccgttct tgtgatgaaa acaaacagct ctgatctgaa 669421 ggcgtatata acggagctgg cacgccaatt tggagatgta accggactat gcctgacctc 669481 gacattgagc agcaagacgg agcgtgtcac ggaaattcct tctttatttc aggatgtgaa 669541 atgcggcaaa tcccgcagga agtttgctaa ccgggatcag gtcattgatt tgcaggccga 669601 cttccctcgg gatgagcagt tcgctcctta ttaccctttt gagctggaaa aacaaattgt 669661 tcagaccatc cggctggaaa gaaaacagga agccaaggaa ctgatagatg gatgtatgaa 669721 ggaactgtcg gaaaaagcgg ccatagacag gcatgtgcat tccgccctga ttcagctgtt 669781 ttcccgcatt caggaggata ttttgcattc cgggctcaat cccagcgaac tgtttcagca 669841 ccggaatccg tttcttgata tttcagaatt gcgcgaacct aacgaagcgg cggcctggct 669901 gatggatgta gtggtgacgc cttacctttc caagcttgag ggcagaaaaa acagacagca 669961 aaagcagctg gcagaacgtg tgattgcgat gattcacgaa cagtatatgg cggacatttc 670021 attggaaagc tgtgccgatg cgcttggcat gaattcctat acgttaagca aggcatttaa 670081 gcaagtgacc ggcattaatt ttatcgatta tgtgacccag atcagaatcg aaaaggcgaa 670141 agaactgctg gtcaatacga ataaaaaaat tcatgatgtg tctgaagaag tcggctatcg 670201 ccacaattat ttcaatcgga tttttaaaaa acaggtcggc atgccgccgg gtgtcttcag 670261 gcaaatgtat caggaaacgc cgtgaaagga gagaacatgt gatgaagaaa ccgattcaag 670321 tatttttagc gggggattcc actgtgagtg actgcccgcc tcatgaagcg ccgatggcgg 670381 ggtgggggca ggtattcggg caattgtttt ctgaaggtgt gctggtccgc aatcatgcca 670441 aaggaggagc gagcaccaat tcttttgtgg aggaaggaag gcttcaagca attgccgagc 670501 acatcacaca aggcgattat ttgttgattc aattcggcca caatgaccaa aaaccgcggg 670561 ggacgaagcc gtactccaca tttcagcagt ttcttacctt gtttgcagat acggcacgcg 670621 aaaagggcgc gcatcctgtg ttcgtcacat cggtgcagcg ccgccgcttt gatgaaaacg 670681 gacggatcga gcatacgctc ggtgagtatc ccgatgcgat gaaagcactg gcgaaggagc 670741 tcgatgtacc tgtgattgat ctgcttgcga aaacaaaggt gctgtatgaa gcatacgggc 670801 cggaggagtc gaagcgattg ttcgtttggt ttcagccgaa tgaacatccg aattacccgg 670861 acggcattga ggacaatacg catttttcgg aaaaaggtgc aatggaggtt gcgaagcttg 670921 tggcagaagg cattgaagag ctcggacttc cgcttaagga ccaccttgtg agccgggagg 670981 gaaaagaaca tgtataagga aggcgcttgc ttgtaccgca atccgctccg gtctaaaagc 671041 gatgtgaagg attggcggat ggagggaggc ggacagatct catttgacga tcacagcttg 671101 cacctgtcac atgtccagga tgaagcgcac tttgtctttt ggtgtccgga aacctttcca 671161 gacggcatca ttgtgacatg ggacttctct ccgatcgagc agcctggact gtgtatgctg 671221 ttttttgccg ctgcgggtat tcgcggcgag gatttgtttg acccaagtct caggaaaaga 671281 acaggaacat accctgagta tcattcagga gatatcaatg ccctccacct gtcgtatttc 671341 cgcagaaaat acgcggagga aagagcgttc cgcacctgca atttaagaaa aagccgcggt 671401 ttccatctcg ccgcaatggg ggccgatccg ctgccttctc cagacgacgc tgattctccg 671461 tatcgtatga agctgatcaa agacaaaggc tatgtgcact tttcaatcaa tggtctgccc 671521 attcttgagt ggatggacga cggcagcaca tatgggcctg tgttaacaaa aggaaaaatc 671581 gggttccggc agatggcccc catgaaagcc gtttacaggg attttgccgt gcatcaagcg 671641 gtgagaagat gaagacgact gtaacggatg cgctttatgc aggctgcgaa gcggtggtga 671701 aaatagcatg gctcaacggg ctgtggctgt tgtttacact tttgggcggc gttcttttcg 671761 gatgggcgcc gagcacagct gcgatgtgtg ccgttataag gaaatggctg atggggcaaa 671821 aggatgtccc gatattttcg ttatttctcg atacctataa aaaagagttt ctcaaggtta 671881 atgcgatcgg attggcgttt tcggctcttt tgctcatatt gtctgccaac tatcattatt 671941 tttctgccag tacgaattgg ctgtcctttg ccgtaacaag ctgcacgctg cttgcagggc 672001 ttttgtatat catcgcgctg atgtatgtgt ttccccttta tgtgcattac cagctcccgc 672061 ttcgcaaata tattccgcag gcactgctgt ttggcgccat gagaccgctg acaactggct 672121 gtatgctgat cgggtgcgga tttgtccttt atttgctgta tacgcttcct ggcctgatcc 672181 cattttacgg cccgtgttta tttgggcttg tgttgatgtt ttttgctctt aggggatttc 672241 aaaagacgga ggcccagcac catcaagccg ggtaacaaaa aaatgacaaa taagcaaaaa 672301 agtgcagtgt ccgaaatagg cagatgcaaa aaagtgaaat tgaagacagc tcacaaagcg 672361 cataaaatcc aatttaagta agcgcttaca gataaatgag aaggagctgt ctgatgatta 672421 gacgaaggaa acgcatgttt accgctgtta cgttgctggt cttgttggtg atgggaacct 672481 ctgtatgtcc tgtgaaagct gaaggggcag cgcggcagat ggaagcgctg aaccgggggc 672541 ttgtagcggt caagacggac gggggcattt ttgtcagctg gcggtttctt ggaaccgaaa 672601 acgcatctgt tttgttcaat gtgtacagag acgggcaaaa actgaatgct gcgcctgtca 672661 aaacaacgaa ctatgtggat aaaaacggtt cggcgggctc aacgtatacg gttcgggctg 672721 ttgtaaacgg taccgaacag ccggcttctg aaaaagcctc cgtatgggcg cagccgtatc 672781 attccgtccc gctggataaa ccggctggcg gcacgacgcc aaagggtgaa tcttacacgt 672841 acagcgctaa tgacgcaagt gttggcgatg tggatggtga cgggcaatac gagctgatcc 672901 tgaaatggga cccgtccaac tcaaaagaca attcacagga tggctatacg ggtgacgtgc 672961 tgattgacgc gtataaactg gacggcacaa agttatggcg gatcaatctc ggcaaaaaca 673021 tcagagcggg cgcgcactac acccagttta tggtgtatga ccttgatggt gacggaaaag 673081 cagaagtggc aatgaaaacg gcagacggga caaaagacgg cacgggcaaa gtaattggaa 673141 atgccaatgc agattacaga aatgaacagg ggcgtgtgct ttcaggccct gaatatctca 673201 ctgtgtttca aggttcaacc gggaaagagc ttgtcaccgc aaattttgaa ccggcgcgcg 673261 gcaatgtgtc ggattgggga gacagctacg gcaaccgtgt tgaccgtttt ctcgccggca 673321 ttgcctacct tgatggacag cggccgagcc tgatcatgac cagagggtat tacgctaaaa 673381 ccatgctagt tgcctataac ttcagggacg gaaagctgtc aaagctttgg acgctggact 673441 cctcaaagtc aggaaatgaa gcgtttgccg gacaggggaa tcacaacctg agcatcgcgg 673501 acgttgacgg ggatggaaaa gatgagatta ttttcggctc aatggctgtt gatcatgacg 673561 ggaaaggcat gtactcgacc ggcttaggcc atggggatgc cctccataca ggagatcttg 673621 atccgggccg gccggggctt gaggtgtttc aagttcatga ggacaaaaat gcaaaatacg 673681 gcttatcttt ccgggatgct gcaactggaa aaatcctttg gggcgtttat gccggcaagg 673741 atgtaggccg gggaatggct gctgatattg acccgcgtta tccgggacag gaggtgtggg 673801 caaacggttc tctctactca gcgaaagggg tcaaaatcgg aagcggggtt ccgtcctcga 673861 ccaacttcgg catctggtgg gacggcgatc tgctccggga acagctggac agcaaccgaa 673921 ttgataagtg ggattatcaa aacggcgtat cgaaaaatat gctgactgca tcaggcgcag 673981 cggctaacaa cggcacaaaa gcaacaccaa cgcttcaggc tgatctgctc ggtgactggc 674041 gcgaggaagt ggtgtggaga acggaggaca gcagtgctct gcgcatttac acgacgacca 674101 ttccgactga gcacaggctg tatacgctga tgcacgatcc ggtgtaccgg cttggcatcg 674161 cctggcaaaa tatcgcctat aaccagccgc cgcacacaag cttcttttta ggagacggca 674221 tggcggaaca gccaaaacca aatatgtata cgccttaact gaaaggggga aggaacgggc 674281 tgcgcgcagc ccgttcccat caaatgaaac caaaaaagag gcaaatggaa tacctgacca 674341 gaggtttgat tgcggtacag acagaacagg gcgtgtttgt cagctggcgt tttctcggca 674401 cggatcatga gacgacggct tttcaccttt atcgggatgg aaagcggatc acccgcgatc 674461 caatcgctga aagcactaat tttctcgatc aaaacggaac ggctgactct gtttatcaag 674521 tggcggctgt caataaagga cgggaagaaa agctttccaa gaaagctcgt gtttggcagg 674581 aaaatgtcct ggaggttcct cttgccaaac cggaaggcgg tgtgacgccg gacggaaagc 674641 cgtacactta cagcgccaat gatgccagtg tcggggatat agacggggat ggagaatatg 674701 aaatgatcct gaagtgggac ccgtccaatt caaaagacaa cgctcatgac ggttataccg 674761 gggaggtgct catagatgcc tataaactgg acggcacctt tttgtggcgc atcaacctcg 674821 gcagaaacat cagagcgggt gctcattaca cgcaatttat ggtgtatgac cttgacggtg 674881 acggaaaagc agaaatcgcc atgaaaacag ctgacggcac aacagacggg aaaggacata 674941 tcatcggtga tgagcaggcc gattttagaa acgaacaggg cagaattttg tccggtccgg 675001 aatatttgac cgtgtttaaa ggagaaaccg gtgaggcgct cacgaccgtg gaatatgaac 675061 cgccccgcgg caagctggag gattggggag acggctatgg aaaccggatg gaccgttttc 675121 tcgccgggac cgcttatttg gatggggagc ggccgagcct tgttatggcg cgcggctact 675181 atacgagaac cgtgctcgtg gcatacgatt tcagaaacgg aaggctcaaa aaacgatggg 675241 tatttgactc caaccagccg ggacatgaag catacgcagg acaggggaac cacagcttga 675301 gcgtggcgga cgtcgacgga gacggaaagg atgaaatcat atacggcgca atggctgtcg 675361 atcatgacgg aaccggcctg tactcaacgg gcctcgggca cggagacgcg atgcatgtag 675421 gggatctgga cccgtcacga aaagggcttg aagtgttcca ggtgcatgag gacgccacga 675481 agccgtacgg actgtcgctg cgagatgccg gaaccggtga gatattatgg ggcgtccatg 675541 ctggaactga cgttggccgg ggcatggcgg ctcatattga tccaagctac aaaggatcgc 675601 tcgtctgggg aattgatccg ccgggcaatg atggcatgtc gtacgggctt ttcacgagca 675661 aaggcgaaaa aatcagcgac aaagcgccct cttcagccaa tttcgccatc tggtgggacg 675721 gtgatttggt cagagaactg cttgatcatg actgggacgg aacgatcggc aggccaaaga 675781 ttgaaaaatg ggatgctgaa aacggctgtc tgaagacgat atttcagccg gccggcgtgt 675841 tgtccaacaa cggcacgaaa ggaaacccgg ttcttcaggc caacctgttc ggagactggc 675901 gggaagaagt gatatggaga acggaagaca gcagcgcgct ccgtatctat acaacaacac 675961 atctcacccg ccactgcttt tacacgctga tgcatgatcc ggtttacagg ctcggcatcg 676021 cctggcagaa taccgcctac aaccagccgc cgcacacgag cttttacctc ggaacgggaa 676081 tgaaaaaacc gccgaagccc gccctgtaca tagcgggaag caaagcggag gcgccgctgt 676141 aggaggacta agggataaga cgcaaaggct gaacgctacg ccaagatgat tagagaactg 676201 gcaggacgaa ccaatgctca agcgctgtac gcaccggttt tttcaaggga agagctatcc 676261 gtgatggaag ctgtataaaa aacgaggagg aatgaaaaaa tggcaaatca tatttatctt 676321 gccggcgatt cgactgttca aacgtatgga gacagcacaa atcaaggggg ctgggggcag 676381 tttctcggct cgcatctgcc ggagcatatt caagtgatca acagagcgat cgggggaaga 676441 agctcgaaaa catttgtgga agagggcagg cttcaggcaa tcctcgatgt gattgagccg 676501 gatgattggc tgttcgtgca gatgggccat aatgacgcgt caaaaaataa gccggagcgc 676561 tacaccgagc cctatactac ttataaacaa tatttaaagc agtatatcgc aggcgcgcgg 676621 gaaaaaggcg cccatccgct tctcattacc cccgtagccc gctttcatta cgaaaacggc 676681 gtgtttttga acgattttcc tgattactgc attgccatga agcagacggc cgctgaggag 676741 aatgtccagc tcattgatct gatggagaaa agtctcgctt tctttactga gaagggcgag 676801 gaaaaagtgt acacctattt tatgatttca gaagggatta acgattacac gcattttaca 676861 aaaaaaggcg caaatgaaat ggcgaaactt gtggcaaaag gcataaagga gctcggcctg 676921 ccattgacag aatcgatcat caaagaaagg tgaaaatgtg atgagaaaac tgtatcatgg 676981 cgcttgctat tatccggaat tatgggatga agagacgatt cagcaggaca ttgacatcat 677041 gcgtgaagtt ggcgtaaatg ttgtgcggat cggcgaattt gcctggtcag tcatggaacc 677101 tgaagaagga aaaattgacg tcggtttttt caaagaaatc atcgcccggc tgtatgatag 677161 cgggatcgaa acgattatgt gcacgccgac gcctaccccg ccgatttggt tctcacatgg 677221 ccggcccgaa cgcatgcatg ccaatgaaaa aagagagatc atggggcatg gctcccgtca 677281 gcatgcctgt acgaacaacc cgtatttccg aaaaaaagcc gccatcatca ccacagccat 677341 cgccaaggag cttggccggc tcccggggct gatcggatgg cagctagaca atgagtttaa 677401 atgccatgtt gcagaatgca tgtgtgagac atgcttgcgc ctatggcatg actggctcaa 677461 aaatcgctac ggggtaattg agcgcttgaa tgaagcttgg ggaaccgatg tgtggagcga 677521 gacctatcag acgtttgagc aagtcccgca gccgggaccg gccccgtttc tgcatcatgc 677581 ctctctacgc actatgtatc agctgttttc gatggagatg atcgcttcgt ttgcggatga 677641 acaggccaaa atcatccgct gctattcaga tgcgccgatc acgcataacg gatcagtcat 677701 gttcagcgtg gacaatgagc gaatgtttca gaatctcgat tttgcctcct atgacacgta 677761 cgcttcgcag gaaaacgcct ctgccttttt attgaactgt gatttatgga gaaatctgaa 677821 acaagggcgc ccgttttgga ttttggaaac gagtccgtcg tatgccgcct cgcttgaaag 677881 ctccgcttac ccgcacgcag acgggtattt gcaggccgaa gccgtatcgt cctacgcctt 677941 agggagccag gggttttgct actggctatg gcgacagcag cgttcaggca gcgagatttc 678001 ccacggttcg gttctcagtg cctggggcga acccaccatc ggctatcaaa atgtgctggc 678061 ggttgagcgg gcaagaaagg aaatcgagcc tattattcta tcgactgaac ccgttcaagc 678121 cgaggcggcg atgacttact ctgacagagc aaaagcattt attaaaactg agcctcaccg 678181 gggactccgg catcgttcgc ttgtgacgca tttttatgaa cgtattctca acacggggat 678241 tcaccgtgac cttattccgg aaggcgctcc actggacggc tatcgcttgc tgtttacgcc 678301 atttgtgccg tatttgtctt ctgaatttat caaaaaagct tcggcattcg ctgaagcggg 678361 cggcatctgg atcaccgggc cgctgacagg aggacgcaca tgcgagcata ccattcatac 678421 cgattgcgga cttggcgaac ttgagaaaac gtcagggatc aaaacacttt ttacctttcc 678481 gatgaatgag aacgtgaata caggaaaagc gtttggcatc acggcgccgc tcggactgtg 678541 gagcgcggtg tttgacacag agagcggaaa cacccttggc acggttgaag caggaccggg 678601 ggcgggccat gcttttctga cggaacggaa ttacggcgag gggaaaattg tcatgctggg 678661 ctcgcttcca tccgggaaag aaggggatgc gatgctggaa gcgctcgtca ggcattatgc 678721 ggaggaagct gttatttcca gccggtcgga tgtgacaccc ggcacgatcg ttgccccgcg 678781 tataggcgaa aacggccttg tgtggatcgt tgtgaatatg gatggaaaag gcgggagcgt 678841 gacattgccg gaatcgggaa cggatttgtt gacgcaccgc ttggaaaagg cggggagact 678901 ggcggtcgga ccgcatgaat accgtgtgat tcaatttgac aatcacagct gattctttgt 678961 atcgaatcag cttttttcta tggagggaga gacagatgaa aaagatcaaa tggttatcag 679021 gacagccaaa ggtgacaagc ggcgtgacgt ggggcatgcc atggaaaaaa ggagaattaa 679081 aaaaaggaga ccgtctggcg cttatgaatg aaaacgcgga aacgcgatat gtgcaaagcg 679141 aaccgtcggc ctattggccg gacgggagca tcaagtggac gaagcacgcg gcggtgtttg 679201 gcggtcagga aaaccaaagc tttacagtgc acaaaagaga agtgccgcag ccaactgaat 679261 cgctcagcat tcttgagaca gagcatgata tccaagtgga tacaggagca ctcgtttgta 679321 ccattcataa aacaggatct gatttcattc aatcattgca gatcaatgga aagccgatcg 679381 ccgcaggcgg gaggctcgtt gcgataagag aaacgagaaa agagtcagcg gcgaaaatgg 679441 ttcttttgca tgaaaggtct gtcagcttta tcaaacgggc ggcgattgag cagagtggtc 679501 ctgtcaaagc agtagtcaaa atcgagggag tgcatgtgct tcataaaacg tatgaggaat 679561 ggctgccgtt tgtcatccga ttaacgtttt atgccgggct gtctgagatc ggccttgtgc 679621 acacgcagct gattgacagg agcggtaaac tagaattcgt taaggggctc ggcatcgaat 679681 tcgacctttt tttggaggga gagccgtaca accgccattt ccgctttgcg ggagagaaag 679741 ggatgtataa agaacccgcc cagctgtttg gcacacgtaa attcaatgaa cgatatccgc 679801 tttatgaaaa acaaatcaat ggcgaaatgc tgtctccaga tgaagagcat aaggaatggt 679861 ttgcacatgg cacacagaat gcggtttggg acgatgtcaa gatcgtgcaa gattccagcg 679921 atcattacag cctgtcaaaa cggaccggaa aagattatgc gtgggttgga atgctgcatg 679981 gcagccgggc gaaggggctc tgctatgcgg gcggaaaaaa tggcggtgtg gctctcggcc 680041 tgcggtattt ctttgagaaa tatccttcag cactggaaat cacaggtctt gccggcagcc 680101 gccccaaaat gactatctgg ctttggcctc cggacggcga agcgatggat ttgcggcatt 680161 atacaggaaa cactcacgtg gccagcgcgt atgaaggctt tgatgaaatg cgctctgatc 680221 cgacaggcat tgcgaacaca aatgaaataa gcctggcgtg cttttcgcac atgccgtctg 680281 acgaagtcct caatgcgctg gctgacaaat ggcaggcgcc cccgctcatt gtatgcgagc 680341 cggacgtcta ttacgaatca aaagcactcg gggtatggag catcattgac acatcccatc 680401 cgctcaaaaa agagctggaa gaacagcttg atgcggcctt tctgttttat aaaaaggaag 680461 tagagcaacg cagatggtac ggtttttggc attatggcga tgtcatgcat acgtatgacc 680521 cgatccggca tatgtggcgg tacgatctcg gcggatacgc atggcaaaac aatgagctcg 680581 ttccgaccct atggctgtgg caggcgtttt tccgctcagg cagagaggat atcttccgaa 680641 tggcagaagc catgacccgc catacgagtg aaacggacag ctttcacctc ggtgaatatg 680701 ccgggcttgg ctcacggcat aatgttgtgc actggggatg cggctgcaag gaagcgagaa 680761 tcagcatggc cgggcttcat aaattctatt attatctgac gggtgatgac cggacgggag 680821 atcttttgac agaagtgaag gatgccgatt atgcccttgt caaaaccgat ccgatgcgcg 680881 ctttttacga gaaaggcaag cacccgactc acgccagaac gggaccggac tgggcggcgt 680941 tttgctcgaa ctggctggcg gaatgggagc ggaccgaaaa ttcggaatat ctcaaaaaaa 681001 tcgaaacggg aatcaactgt ctgaagcggc tgccgctccg cttattatct ggcccgacat 681061 ttgaatatga tccggcgacc tcgatgcttc atcatatggg agacggcatt gcgggcggat 681121 atcatatgat cattgccttc ggcgcgccgc aagtgtggat ggagctggct gagcttcttg 681181 atgactggga atgggaggat atgctgagtg aattcggcga attttacaca ctcagtgatg 681241 aggaaaaacg aaaaaaaagc ggaggcgctc ttcatgacgg gcattttcac tggccgatgt 681301 tcgccgccgg tatgacagcc tacgccgcaa gaaaaaagca agatcctcat ctcgccgcca 681361 aagcgtggaa tcttttgcta gaagataagc tcagccatac gccgcttccg atcaaaccgg 681421 agcgcatcga gacatggacg cagctagagg agcttccatg ggtgacaacg aacactgtct 681481 ctcaatggtg tttaaatgtc atagcggcgc tggaactgat cggagattcc cttccggcaa 681541 aaaaagaaac atcgggcaaa aaaggataac agccggaatt tcataggaga aatggtgcaa 681601 aaaatgaaga ttgcaagaat ttatgtaagc gctttatatt gagaggggca aaggggaaat 681661 gcaaattgaa aaaaggggga cttacgcaac atgaaaataa gaatgcgaaa aaaatggatg 681721 gccttgccgc ttgctgccat gatgatcgcc ggatgcagcc attcggaaac atccaattca 681781 gcaagcggtt cgaaagatac gatcaaaatt atggcgccgc tcttatcgcc ggaaagccca 681841 agtgataaga gcccttcatt aaaagcgctc gaaaaataca caggcaaaga gattaaggtc 681901 acatgggtgc ctgattcatc ctacaacgac aaattcaaca tcgtcatggc ttcaggagag 681961 atgcctcacg cgattgtcat taaagataag tcagccggct ttatcaaatc tgtcaaagca 682021 ggggcgtttt gggagctgtc tccttattta aaagactaca agaatttaag ccaggcagat 682081 gaaaagattt tgaagaacag ctcggtgaac ggcgaggtgt acggaatcta cagaacgagg 682141 gatctgatca gggcgtgtat gatcatcaga accgactggc tgaaaaatgt cggtctggat 682201 atgccggaaa cgcttgatga tttctatgaa gtgctgaaag cctttaagga aaaagatcct 682261 gacggaaacg gcaaggatga tacgtacggc atggtcgtgc cgaaatggat gggactcggc 682321 aacggaagcc catgggatgt tctgcaaatc tggttcggcg ctccgaaccg ctacggtgtt 682381 gaaaacggaa agctgattcc agattttaca acgaaggaat acatggatgc gctcacgttt 682441 tttaaaaagc tctatgatga gggcttgatc aataaggact ttgctgtcat ggattctgcg 682501 aagtggaatg atccggttgt aaaaggaaaa gcgggtgtca tcgttgatac aggctcaaga 682561 gcgtctcaaa tccaaagcgc gatggaggag gcggatgagt cgaacaagga tatcattgat 682621 atcgtcggct cgcttgaggg accgaatggc aagcgcacct tcccgacatc tggttattca 682681 ggcatgatca cgataccaaa atcaagcgtc aaaaccgaaa aagagctgaa agaggtgctg 682741 tccttcctcg ataagatgaa tgataaggaa gcgcagattc tcacgaacaa cggagtgaag 682801 ggccgcaatt acgagctcaa ggacggcgta ttcacctcac ttgaaaaaaa caataaatct 682861 ctcctgtatg agcatgaagg cttggcacag ttcagcatgt cgattccgaa aagcgagtat 682921 tacatcgaag accagaaaac caagctcttc cagcatcgca aggacatcat aaccgaagga 682981 gaaaaaatag ccgtctttaa ccctgctgag tcgcttgtat ctgatgtcta tacccaaaaa 683041 ggagcccagc ttgacaacat catcctcgac gcgagaacac aatttatcat tggagaaatt 683101 gatgaaaaag ggttcgatga tgcggtggag ctttggaaaa aaagcggcgg caatgaactg 683161 atgaaggact tgaacaaatt gtaccaatcg tcaaaataaa ccgatgcgcc tgcctttcgg 683221 cgggcgcccc ggtatcacga aaggagaaca gatatggaaa cagtgccgaa gaagagagat 683281 gcacctgttc tcaccgctgg aaaaggcatc agctggatgg ctgcgctcaa acgggacaaa 683341 tggctttatc ttcttcttat tcccggtctg ctttatttct tgattttcaa atacttgccg 683401 atgtggggtg tgctgatcgc ttttaaagac tattcgccat atctcggctt ctggaaaagc 683461 gaatgggtcg gctttgatta tttcaaagac ttttttatga atccggattt tttccggctg 683521 ctgcgcaaca ccctcatgct ggcgagtctg gatcttttgt ttgcctttcc cgcgcctctc 683581 attttggctc tgcttttgaa tgaggtaaga aaggccgtgt ataaaagatg tatccaaacc 683641 tttatttacg taccccattt tgtatcatgg acaattgtgg tcagcatcac cttcgttttc 683701 tttactgtcg atacaggtgt gatcaacaaa ttgattatga gcctgacagg tgagcagatt 683761 tctttcttgt cggatgcaga ctggttccgg ccaatgattg tgatgcaaag catttggaag 683821 gagacaggct ggggaacgat tctatttttg gcagcgcttg ctacggttga tcaagagcag 683881 tatgaagcgg ccatcatgga cggagcgggg cggttcagga gaatgtggca tattacgctg 683941 ccggcgatta gaagcaccat tatcgttttg ttgattttaa gaatcggcag ctttttgaat 684001 cttggctttg aacaggtgta tttgatgacg aactcactca accgcagtgt ggctgacatc 684061 ttcgacacgt atgtgtacat gatggggatt acccaagggg cgtatagcta cagcacggcg 684121 gtcggtttgt ttaaatcagt tgtcgggatt atcttgattt ttggcgccaa ttacattgcg 684181 aaaaagtttg atcaggaagg attgttttag aggagggaga ggtatggctg aaattcacac 684241 gatgcacaac accaaagccg gacgggtgtt tgacgtctgc aacattctgt ttctcggcgg 684301 tgtcggcgcg attaccattt tgccgttttt atatattatc gccggttcct ttgcgacaga 684361 agcggaactc gcccagcgga gcttctttat tttcccgaaa acctttacac ttgatgctta 684421 caagtatgtg ttttcgacac cgacgttcct tcgaagcatg ggcgtgtcca tcttcatcac 684481 ggtggttggg acggctgtac agctgttttt taccttcacg atggcgtatc cgctggcgaa 684541 acggcatgtg aagggacgga atctgctgtt gaatctggtg attttctcca tgctgttttc 684601 aggcggcatg attccgacgt accttgtcgt aaaatcactt ggccttttgg atacgtattg 684661 ggcattgatt ctgccgatgg cgattaatcc gttcaacctt attattatca aaaacttctt 684721 tcagcagctg ccgcgcgagc tggaggaatc agcaaaaatt gacggctgtt ccgaaatcgg 684781 cgtcttctgg cggatcgccc tgcctctgtc aaagccagtt attgcgacct ttgcgctgtt 684841 ttatgcggtc gggatttgga atgatttctt ccacgctctc ttatatatca atgacagtgc 684901 aaaatggccg ctgcaaatgg tgcttcgcca agtcacaatt ttatcggatt taacggcgac 684961 caatggtgat acgatgcaaa atgcagttcc gccggagcag ggaattaaac tcgctgtcat 685021 tgtcattgcg acgctgccga ttttggcggt ctatccattt ttacaaaaac actttgcaaa 685081 aggaatgctg atcggttcgg tgaaaggctg agaaagggag tgtttcatat cagtacatta 685141 gatcagatta agattgccta tatcggcggg gggtcccaag gctgggccag aagcctgatg 685201 agtgatttgt cgattgatga acggatgtca ggcacggtgg cgctctatga tcttgatttt 685261 gaagccgctc agaaaaatga agtgatcggc aatcacagcg ggaacggcag atggagatat 685321 gaggctgttt ctactttgaa aaaggcgtta tcagccgcgg atatcgtcat tatttccatt 685381 ttgccgggat cactggatga tatggaagtc gatgtgcact tgcctgagcg ctgcggtatt 685441 tatcagtctg taggtgatac tgtcgggcct ggagggatca tcaggggctt gcgtgctgtg 685501 ccgatatttg cggaaattgc ccgggcaata agagactacg cacctgaatc atgggtcatt 685561 aattatacaa acccgatgtc tgtctgtaca agagtgctgt ataaagtgtt tcccggcatc 685621 aaagcgattg gctgctgcca cgaggtattc gggacgcaaa agctattggc ggaaatggtc 685681 acggaaaggc tggggattga ggtgccgcgg cgtgaggata tccgcgttaa tgtgctcggc 685741 attaaccatt ttacatggat cacaaaagcc tcttaccgcc atattgacct gttgcctata 685801 ttccgtgaat tcagcgcgca ctatggggaa tcaggatatg agctggaggg ggaatgctgg 685861 agggacagcg tcttttgttc ggcacaccgt gttgcgtttg atttatttga aacgtatggc 685921 gccatccctg ctgcgggtga caggcatctg gcagagtttc ttcccggccc atacctcaaa 685981 cagcctgaag tatggaaatt tcatctcaca cctatatcat tcagaaaaca agacagagct 686041 gagaaacgac aagaaacaga acggttgatc gtgcaacaac ggggcgttgc tgagaaagct 686101 tcgggagaag aaggcgtgaa catcatagcg gctcttctcg gattgggtga actcgtcaca 686161 aatgtaaata tgccgaatca aggccaggtc ttaaaccttc ctatacaagc cattgtcgaa 686221 acaaacgcat tcatcacaag gaaccgtgtc cagccgattt tgtccggagc gcttccgaaa 686281 ggtgtggaaa tgctggcggc taggcatata tccaatcagg aggcagtggc ggacgcaggt 686341 ttaacaaagg atactggcct cgcgtttcaa gccttcctca atgacccgct tgtccagatt 686401 gaccgcagtg atgcagagca gcttttcaat gacatgctcc aatgcatcat gcaaagctga 686461 gcttgccgat tagctctttc cggtttagaa aggaaagcat tgaccatact gatagtataa 686521 tcaagaagta ggtgctatca atatgggaaa ttatttaagt gttgcggtag aactggtctg 686581 cggtttaggc attttattta tcatcttaaa gcttctcggg aaaacccaat tttctcaaat 686641 tacgccgttt gactttattt ctgctttaat tttaggtgaa ttggtcggaa atgccgtcta 686701 cgatcatgaa atcaaaatca aagaaattat ttttgcttcg ctattgtggg gcgtgctgat 686761 ttatattatt gaatttatca cgcaaaaaat gaaatcatcg cgaaagttct tggagggcga 686821 gccgaatatc gtcatccgca aaggggagct tcaatataaa gtaatgaaga aaaataagat 686881 agacattaac cagctgcaaa gcctattgag gcaagctggg agcttttcga tccaagaagt 686941 agaatatgcg attcttgaaa caaacgggat ggtcagcgtg cttccaaaat cagactttga 687001 caaaccgaca aataaggatt tgcagattcc ttcgaagtcc gtttctctgc cgatcacgtt 687061 aatcatagat ggagagattg tgcgggataa tttgaaggaa gcaggtgtgg atgaacagtg 687121 gctgaaacaa gaattgaaaa agaagaacat tgataagaca gaggacgtgt tatttgcaga 687181 atggcataaa aataagccgc tgtatactgt aacgtacgaa caaagcagat caacatgact 687241 cttagaaaaa agcttgcagc aaggcgcaag ctttttattg attgtatgtc ccttgtttga 687301 cagcacgtac atggtacatg ctcacttcag tgctgatcag atagtcaggc tttggtttgc 687361 ctttgtttgc tttatggccg gcgatatgcg catcgctttt ttcccattgc ttccagtgat 687421 cctctgattc ccagcgaatc atgacaacaa cttcttcatc accgcggcgc acatttttct 687481 caagcactgt cacatcaatt aaaccttctt gtttttcaat gattccttca gcgctgaaac 687541 gttctatgac tttatctgca aagccttctt taaccgtcat ttttctcaac tgtacaaaca 687601 tttgtctcac tccaatcatt ctcacatatg aataattgta aatgaaattc attctcaatg 687661 tcaaagaaag cgcagggcgg aatcgaaccg ccgtgcgcaa cagtttattc ttttaataaa 687721 aacacatttc cgtcttcgtc cttaaattga acgaaggtgc cccactccat ttgattgggc 687781 tcaccgagaa attctacacc gtttgtcttc attttctcgt atgtaccaaa gatgtcttcg 687841 cattcaaaca caatagaagc cttcatttgc tctgagcctt tcatcatggc tttcgggtaa 687901 atgactaaac gagtctcggc tccttttggc gcaacctcca gccagcttgc ttcaggtccc 687961 attgggtgat ccgctgcaat atcaaagcct accttctctg tccaaaattg cttcgctttc 688021 tgctggtcct cgacatatac agcaacagtg ccaatttgtt tgatcatagg gaaacctcca 688081 agttgaaaag ataataatac tataacctgt ttacggccga agtaacataa aaaaatcagc 688141 cgggaaaccg gctgattatt aaaatgagca gcttacaaca tcgatgtgat ttgtgtctaa 688201 ggcgaaataa acccagcggc gccgtgagga atcccaataa aagccgccga cggatcttct 688261 gccaaggatg atcgggtaaa accaaaatga gcggccattg gttaaccaga cataggtaaa 688321 tcggaaaagg caaggacgaa tggtgattgg ttcaactaac aaaacggctc cttgagaacc 688381 ctgcggtttt gggggtttcg ctggtatttg ggaaggagga ggtccctgcg gcgcaccgcc 688441 gaagcctggg ctggcaccgc tgccaatacc agggccggag ccgccgccaa agcctggaac 688501 agcaccaccg ccaatgccag gaccggagcc gccgccagag cccggaacag cgccgctgcc 688561 aatgccaggc catggatatc ggtattcata ttcaaaagca ggccaaggct cataaaaatg 688621 ccccgcaaac atataaggat caacataata catgtgataa cgtcctttct cattgtaaac 688681 tgtacattgc agtttatgcg ggcggactct tattggtgca ttcgcctaag gatatgaagc 688741 tggaatgctc tcagagagca gaatcatttg atttttctct agtcttattc acaattccga 688801 tttatcattt tataatgaaa gtgcttctat tacgaaaaag gagacagacc gtgaatatcg 688861 atcaattatt atatcaatat atcatagaca acactgcgga tattactgag aaatggttca 688921 gtttgcgttg ccagctaaaa ggcgagctat attccgccag ccatttaagt gaagaaacga 688981 aaacactttt aaccgagcag catacattta ccaatataac aatcgcaagc gcatttctgg 689041 aggatcaaac cgattttcaa gaaaacatga caaaatgggc gcaaaacgtt gcgaaaaaca 689101 gggtagagca ggatgttcaa gtgcatgagg tcgtagaagc catatccaat tcaagaatct 689161 cattctggga cgcagtcgcc acatttataa aagagaatca ggagattgtg acaaatgagg 689221 atgcagaccg atggaaccgc attgtgaatc agtcgttcga taagctgatt attgaattct 689281 ccgagcagta ccaaaaattc atgctgatga ggcttacatc tcagcaggaa ctgatctcag 689341 agcttggctg cccggtcatt tccattgccg atggaatcgg gatattgccg cttatcggct 689401 ccattgatac aaaacggcac aggtcatttt agaaacagtg ccggtccgct gtgtcgagag 689461 aaaaatcaca agcctcgtcg ttgatctttc gggtgttccg attgtggata ccatggtggc 689521 tcagcaattg tacaacctgt ctaaaacact tttcttatta ggcgtcaaag ccgtattttc 689581 aggaattcgc ccggatgtgg cccaaacatc gattcaattg gggcttgatt ttagtgaata 689641 tgaaacgtac ggcacgctga agcaggcatt agaaaacatg ggtgtccgct gtattgttga 689701 ggaattggaa gaaaacaaat aggaagtttc caggcatatg attgtccgtc accgggtgat 689761 catatgcctt tttgatttga acagaaatca ccattgattt atcgaaaaaa acataatatt 689821 ataattctta taagaatact gtgaattaaa acctattcaa caggggggaa ggtcttttgg 689881 tttctaaatc aacgattgat ccggaagtga ttgaaaaaat catcagctcg ctggaaacac 689941 tcgatttcgg cacggttcag attacggttc atgattctca gattacccaa attgagaaaa 690001 tagaaaagca ccgtttttcg ctgaaaagga aagaatcaaa atgataatgt aaagggcgtt 690061 tgttttcatt aaattctcct taaaacatat acatatttca tccaattttt atataataga 690121 cctttaagat cattttttag gaggattttt gacatgcaag ctacggttca cgagagtaag 690181 caatcgatca tgcaacgcat tttgacagtc tttgtcttca cattgctgat cgcgactgtc 690241 ggccttttta tcggccaatt tgttcctgtc gctttgatgc tgccgctttc tattcttgaa 690301 gtggcgatga ttattctggc cttctggatg cgcagaagaa aagcggtcgg gtatgcgttt 690361 gtatatacat tcgcgttcgt ttccggcatt accttatttc cgatcgtcag ccattacgct 690421 tccatcgccg gcgcctatgt cgtgctcgaa gcctttggct ctacatttgt catttttgcc 690481 gtcttgggca caatcggcgc aaaaatgaag aaggatttat ccttcctgtg gtcgtttctg 690541 ctggttgcgg tgctcgcact cgcagtggta gggattttca acattttcag cccgttaaac 690601 tcagcggcga tgatggcgta ttccgtgatc ggaaccatcg tcttttccct ttacattttg 690661 tatgatttga accaaatcaa gcaccgccac attacggaag acttgattcc ggttatggcg 690721 ttatcgctgt acctagactt tatcaacttg ttcatcaacc tgctccgctt cttcggcatt 690781 ttgagcagtg atgattaatg aaaaagcgtc tgtcattgga taggcgcttt ttgccataca 690841 tcaaaaaggc aggtggagta ttggtgaaaa aacaaatggg cgcatatgta tctctggcag 690901 cagctatggc gatcgtcggc agttctgtcg ttgtcggcaa gctgatggtc gaacggattc 690961 cggtctttct ttcctcagga ttgcgttttt tgatcgcttc tgtcgtattg ctcatgctgc 691021 tgttttgcat tgaaaaaggg tttccggctt tgacgaaaaa agatgtgttc gtattactgg 691081 tgcaatcatt cacaggcgtg tttttgttca gtatttgcct gctgtatggg gttcaatata 691141 cgacgggaac ggaaagcggc attttgacaa gcacaacccc catgttgatc ggtattttat 691201 cctttttcct gctgagagaa aaaattgaga aaaagacgct gatcggcatt ttgctggcgg 691261 tttgcggcgt aatggcgatt aatttgtttg gagccgggag ccaagacggg acgccgcacg 691321 ccttattcgg gaacatgctg atcattgctg cagtcattgg cgaagcgttg tttacattga 691381 tggccaagct gctatccccg catatttcgg cactggcgat ttcgaccttc gtatcgctct 691441 tcggcttcct gttttttctc ccgtttgctt tgtttgaggc ctcttcattt gattacagcg 691501 tgccgactgt tttggattgg tcgtatgtgc tgtattacgc gctttttgtc actgttttgg 691561 cgttttactt atggtatagc ggggtgacga aggtgccggc gggtgtatcg ggcattttca 691621 catccgttct tccggtctca gctgtcattt tgtcaggcgt gatattgaag gagccatttg 691681 agtttgtgca tttcatcggc attgcatgtg tcatcggcgg catatttgtt acggtcataa 691741 agaaaaaaca gccggatgcg tatccggctg cagaagaaaa gacgctatag cctgtccgga 691801 tcggacgggt tttttagtct ttaaacacgc tcagcctttc aaaaagatca ccaagcatct 691861 tcacgaacat gtctttttcc tcgtcgctgt agttttccat gacagcggat attttgctga 691921 aatggccggg cagaaattgc tccaggcgtg ctttgccttc tgttgtcagt tcaatgctga 691981 tttttcgttt atcctctgtg tgatgcctgc ggctgacaaa accgtctctc gccagcccgt 692041 ctagcaggcc tgtaattgtt gctttcgtga catttgaccg cttggcaagc tctgtcggac 692101 ttaacctatg atccttggca tcaaagagca gcatcaggat tttgaatttt ccttctgaaa 692161 gccctcggcc agcaaagtaa tgctccatca catgattcat tttttttgaa atatcaaaaa 692221 gagataaaaa caattcaaga gagccggcgt caatattggc atacgtttcg gcgtgctctg 692281 ttatatgctt atatttcggt aaatgtttta attccatcgc aattagctcc cgtacattcg 692341 ttgtgacacg attataaagg agggaaaacc ataacgcaac ttggcttgga gatgattgac 692401 agcttttctt gggacatagt aaggtaatat agttaggcgc ctaactaata catatagagc 692461 tgaaaaggtg gttattgata tgaaacatat gttaatagca ggaggcggaa tcggcggctt 692521 gtcagcggcc atttctctcc gtaaggcagg gttttccgtc accttatgtg aagcggcttc 692581 agaaaatcga aaaacaggtg cggggattct tcagccgcaa aacgcactgg cggtgttgaa 692641 agaactgggc gtattcgaag attgctgtaa gcacggcttt caaacagaat ggtttaaaac 692701 gtttgatgaa caggggaatt tgctgtttca agtcagtgaa tcctttttag acgattcact 692761 tccgggacgc aataatatcc tgcgcaaaac gttaaatgac attctcatga agcatgccga 692821 ggcagtgggt gtagacatca agtgggggaa aaaggttgtc gcctatgaag aaactgctga 692881 atcggtcact gccttatgtg aagatggaga aaagatgcag gctgacattc tggcgggctt 692941 tgacggcatt cactccgttg ttcgtgataa gatgctgcaa aaggaaacgg aaaaagagca 693001 tctcggcatg ggagcgtggc gcttttatat cgaacttcct gattacacat tcgaggacgc 693061 aacattcatg tatagaagcg gagacacaca aatcggggtg gtgccattgg cacaacacgc 693121 tggctatgtc ttcgtcctcc agccttgcac gagcgattac tgggatgagg aagatacccg 693181 gtttgataga gtaaaagaga ttctttctgg ttttcggggg ctggattttg tcacaaagca 693241 catgtcaaaa cagcatcctg tcatctttaa caaactggag caggtcgccg tgcaggagcc 693301 atggcataaa ggccgcgtca tcatcggagg agacgccgcc cacgccggtg cgccaaccct 693361 ggcacaagga gcggcaatgg cgatcgagga tgccatcgtc ctcgccgaag aactccaaaa 693421 ccacgccgac cacgaaacag cattacaggc gtactataaa agaagagccc cacgagcgct 693481 caaagtccag aacctatcat ctgaaatcgt ccgccgcagg ctgaaaggag agccgggagc 693541 ggaagaactg attggggagt gctatgcggt gttgagggaa gggtattaaa taggaaaagt 693601 ccagaaagtg atttctggac tttttagtct tgctctgttt tattccttat ccgctcaatc 693661 acctcatgca gcccctcagg cttataaaac tccaccggtg aactgccttt ctcaaacgaa 693721 atcgtctcgg cttcaatcag cgcgacatag cgcccgttta cttttgcgag atgaatagaa 693781 tcgccaaaat ccgctagcaa tcccttaatc tctgtttctc cgactttcat tttcagctgg 693841 gcctctggcg tgtgctcgat gatttgggcg gaggcttcga tgacttgatg ggtgtcgagg 693901 cgctcttgga tttcccgttt ttcgcttgct tcccaaatct caatgtcgtg ctcgaactgc 693961 ttgagttctt cgctgttgtc ttcaaatgtc tcgtagacgt gctcttgtac catgttcatg 694021 acctgatttt tcatgatttc tggcatcgat tctccgtact cgacgaattt cagaaagtcc 694081 tcaaaatagc gggcgtgcga ggcctggtgg attttcagtt caccttcctc gaccattcct 694141 tcctctggca tgtacgggta ttggatgctt ttcatgtttt ttgtcgtgat cgccatttcg 694201 acttttttaa tgagagaaga cgcgtcagag atgcgggcga ccttcggctc aaaatcacat 694261 ttcataatga agacaaatga ctcatcaaag tattttctcg gcacggccga agcgacgaga 694321 aacacgccgc cgcgaaccgc gcttgtgtca aggtacgtgc ggacgaactg ctcgctcagc 694381 tcattgaagt cttcttttgt ttccgccaga cgcgcgcggt tgaacatgtt gtagtttggg 694441 ttggaatcga gctcgtggcc gggctcgacg ataaaatggc cgattttcgt cggcacctgc 694501 tcggactgcg gatggcggtc ggctttccgt ttaacgattt ttttcagttc cccgtcgaga 694561 aagtccttca gctcgctttc ttcaaattct cccgtatcaa gggtctggaa gtgcttgaac 694621 tgcttgttcg cctgctcatc tttgccttcc acctgtatga cataaaagga taaaaaccga 694681 atttcaaaat ccatatataa actcacctta ttcgcgtatt gtacagcttc tcaagtatag 694741 aaaaaacagc gatcatgcgt caattgggag aacggaataa tcatgaccat gaaagggaaa 694801 tgtagtcaaa tagaaggcat ttcatacgga aaggaatggt tcgatgaagg aaacaagccc 694861 gattcctcag ccgaagacgt ttgggccgct cggcaatttg cctttaattg ataaagacaa 694921 accgacgctt tcgctgatca aactggcgga agaacagggc ccgatttttc aaatccatac 694981 acccgcgggc acgaccattg tagtgtccgg ccatgaattg gtgaaagagg tttgtgatga 695041 agaacggttt gataaaagca ttgaaggcgc cttggaaaag gttcgcgcat tttccggtga 695101 cggattgttt acgagctgga cgcatgagcc taactggaga aaagcgcaca acattctgat 695161 gccgacgttc agccagcggg ccatgaagga ctatcatgag aaaatggtcg atatcgctgt 695221 tcagctcatt caaaaatggg caaggctcaa cccgaatgaa gcagtcgatg tcccgggaga 695281 tatgacccgg ctgacgctcg acaccattgg gctatgcggg tttaactacc gctttaacag 695341 ttactacaga gaaacgcccc acccgtttat caacagcatg gtgcgggcgc ttgatgaagc 695401 gatgcatcaa atgcagcggc ttgatgttca agataagctt atggtcagaa caaagcggca 695461 attccgctat gatattcaaa cgatgttttc gttagtcgac agcattattg cagagcgcag 695521 ggcgaatgga gaccaggatg aaaaagattt gctcgcccgc atgctgaatg tggaagatcc 695581 ggaaactggt gaaaagctcg acgacgaaaa tatccgcttt cagatcatca cgtttttgat 695641 tgccggccat gaaacaacga gcggcctgct ttcctttgcg acttactttt tattgaagca 695701 tcctgacaaa ctgaaaaagg cgtatgaaga ggtcgatcgg gtgctgacgg atgcagcgcc 695761 gacctataaa caagtgctgg agcttacata catacggatg attttaaatg aatcactgcg 695821 cttatggccg acagctccgg ctttcagcct ttatccaaaa gaagacacag tcattggcgg 695881 aaaatttccg atcacgacga atgacagaat ttctgtgctg attccgcagc ttcatcgtga 695941 tcgagacgct tggggaaagg acgcagaaga attccggccg gaacggtttg agcatcagga 696001 ccaagtgcct catcatgcgt acaaaccatt cggaaatgga caacgggcct gtatcggcat 696061 gcagtttgcc cttcatgaag ccacacttgt gttaggcatg attctaaaat atttcacatt 696121 gattgatcat gagaattatg agcttgatat caaacaaacc ttaacactta agccgggcga 696181 ttttcacatc agtgttcaaa gccgtcatca ggaagccatt catgcagacg tccaggcagc 696241 tgaaaaagcc gcgcctgatg agcaaaagga gaaaacggaa gcaaagggtg catcggtcat 696301 cggtcttaac aaccgcccgc ttctcgtgct gtacggctca gataccggca ccgcagaagg 696361 cgtcgcccgg gagcttgctg atactgccag tcttcacggc gtaaggacaa agacagcacc 696421 tctgaacgac cggattggaa agctgccgaa agagggagcg gttgtcattg tgacctcgtc 696481 ttataatgga aagccgccaa gcaatgccgg acaattcgtg cagtggcttc aagaaatcaa 696541 accgggtgag cttgagggcg tccattacgc ggtatttggc tgcggcgacc acaactgggc 696601 gagcacgtat caatacgtgc cgagattcat tgatgagcag cttgcggaga aaggcgcgac 696661 tcggttttct gcgcgcgggg aaggggatgt gagcggtgat tttgaagggc agcttgacga 696721 gtggaaaaaa agcatgtggg cggatgccat caaagcattc ggacttgagc ttaatgaaaa 696781 cgctgataag gaacgaagca cgctgagcct tcagtttgtc agagggctgg gcgagtctcc 696841 gctcgctaga tcgtacgaag cctctcacgc atccattgcc gaaaatcgtg aactccagtc 696901 cgcagacagc gatcgaagca ctcgccatat cgaaattgca ttgccgccgg atgttgaata 696961 tcaagagggc gaccatcttg gcgtattgcc aaaaaacagc caaaccaatg tcagccggat 697021 tcttcacaga ttcggtctga agggaaccga ccaagtgaca ttgtcggcaa gcggccgcag 697081 tgcggggcat ctgccattgg gccgtcctgt cagcctgcat gatcttctca gctacagcgt 697141 cgaggtgcag gaagcagcca caagagcgca aatacgtgaa ctggcgtcat ttacagtgtg 697201 tccgccgcat aggcgcgaat tagaagaact gtcagcagag ggtgtttatc aggagcaaat 697261 attgaaaaaa cgaatttcca tgctggatct gcttgaaaag tatgaagcgt gtgacatgcc 697321 gtttgaacga tttttagagc ttttacggcc gttaaaaccg agatactatt cgatttcaag 697381 ctctccaaga gtgaatccgc ggcaagcatc gatcacagtc ggtgtcgtgc gcggcccggc 697441 gtggagcggc cgtggcgaat acaggggtgt ggcatcaaat gatttagctg agcgtcaagc 697501 cggtgatgat gtcgtgatgt ttatccgcac accggaatcc cggtttcagc ttccgaaaga 697561 ccctgaaacg ccaattatta tggtcgggcc aggcacggga gtcgcgccat ttcgcggttt 697621 ccttcaagcc cgcgatgttt taaagcggga gggcaaaacg ctcggtgagg ctcatctcta 697681 ttttggatgc aggaacgatc gggattttat ttaccgagat gagcttgagc ggtttgaaaa 697741 agacggaatc gtcactgtcc acacagcctt ttcccgaaaa gagggcatgc cgaaaacata 697801 tgtccagcat ctcatggctg accaagcaga tacattaata tcaatccttg accgcggtgg 697861 caggctttat gtatgcggtg atggcagcaa aatggccccg gatgtggagg cggcacttca 697921 aaaagcgtat caggctgtcc atggaaccgg ggaacaagaa gcgcaaaact ggctgagaca 697981 tctgcaggat accggtatgt acgctaagga tgtctgggca gggatataga taaagaagac 698041 tggagacatc cagtcttttt agtcctttcg aaaaaatggt gatcgcgcta aacattgatg 698101 catacaataa cttcagtccg ccggaagggc gggctgtctg caaaacctat ttttcgtttt 698161 tgctagttta tgttattctt atactcggta tctatttctt ttttcaaagg cacacatgac 698221 aaaagaaatc ctttttttat ttccgagaaa aaaatgtgaa acgaaatgaa ggtttctttc 698281 gtccagtgat tggtttccaa atggttgtaa taaaaatgat atggtgcgaa acataaatat 698341 tccggcttgc cgcggtgtat ttattgttgt gtgatgcctt gattttgttt ggaaagaagg 698401 aattggaagg caggatataa agagcaggta aatatgaatg aagaacttaa agtgtttaag 698461 aaagtagagg ttgccatgaa gaaacttttt tcttacaaac ttagcttttt tgtgctggct 698521 gttatactgt tttgggcaaa aacgtattta tcctacaaga ctgagtttaa tcttggggta 698581 aaaggcacaa ctcaggagat cctcctgata tttaacccat tctcaagcgc cgtcttcttt 698641 ttaggactgg ctttgctggc gaaagggcgt aaatcagcca ttattatgct gattatcgat 698701 ttcttgatga catttgtgtt atatgcaaat attttattct atcgtttctt tgacgatttc 698761 ttgacgttcc cgaacattaa acagtccgga aacgttggaa acatgggaga cgggattttc 698821 agtatcatgg ccggtcatga tattttctat ttcttagata ttatcatttt gattgcggta 698881 ttgatctgga gacctgaatt aaaagaatac aaaatgaaaa aacgctttgc atctttagtg 698941 atcctttctg ggatcgcact gtttttcatc aacctgcact atgcggaaaa agaccgtccg 699001 caactgctga caagaacgtt tgaccgcaat tatattgtga aatatttagg tttatacaac 699061 tacaccattt atgacggtgt acagacggct caaacagaga cgcaaagagc ctatgcaagc 699121 agcgatgatt taacaagtgt cgagaattac acgacgtctc attatgcgaa accaaacgcc 699181 gagtacttcg gctctgccaa aggcaaaaat atcattaaaa ttcacctcga aagcttccag 699241 tcattcctga ttgactacaa gctaaacggt gaagaggtga cgcctttctt aaataaactt 699301 gcgcacggcg gggaagatgt gacgtatttt gataacttct tccatcagac aggccaggga 699361 aaaacatctg atgccgagct gacaatggat aactcgatct tcggtcttcc tgaaggctcc 699421 gcgtttgtga cgaaaggcga aaacacctac cagtcgcttc ctgcgatttt agaccagaag 699481 gaaggctata caagcgccgt cctgcatggt gattacaaat cgttctggaa ccgtgaccag 699541 atttacaaac atatcggata tgacaagttc ttcgacgcaa gcacgtatga tatgtcagat 699601 gaaaatgtga ttaatatggg gcttaaggat aagccgttct ttacagaatc gattccaaag 699661 cttgaatctc ttaaacagcc attttatgcg catttgatta cattgacaaa ccattatccg 699721 tttaaccttg atgaaaaaga cgcgtctctt aaaaaagcga caacaggcga taacacagtt 699781 gacagctact tccagacagc gcgttacctt gacgaagcgc ttgagcaatt cttcaaggag 699841 ctgaaggaag ccggcctgta tgacaactca gtcatcatga tttacggtga ccataacggt 699901 atttctgaaa accataaccg agcgatgaaa gagattcttg gaaaagagat cacagattat 699961 caaaacgcac agaaccagcg tgtgccgctg atgatccgcg ttcctggcaa aaaaggcgga 700021 gtgaaccata cgtatggcgg cgaaattgac gtcatgccga cacttctgca cttagaagga 700081 attgattctc agaaatatat caactttggt actgatttat tctctaaaga ccacgacgat 700141 acggtggcat tcagaaacgg agacttcgta acgccgaagt acacatcagt cgacaatatc 700201 atttacgata cgaagacagg tgaaaaactg aaagcgaatg aagaaacgaa gaatctgaaa 700261 acaagagtga accagcagct gagcctttca gacagtgtcc tgtacaaaga cttgctgagg 700321 ttccataaac taaatgattt caaagccgtt gatccgtcag actatcatta cggcaaggag 700381 aaagaaatca aataagatga aaaagagcct tgagcgggcg cattgccttc gctcaaggct 700441 ctttttttgg ttatacaacc aacttgaaaa aatagattcc atttggtcac caaggctggc 700501 tttctctcat atcattacag tagattttga aaccggattg aaatcggaca aattatcggg 700561 gaaatgcctt gatagattgt gaagatgtac caggtttcga actcaatatt catagagatg 700621 aggggtagag atgaaagcgg tcattctctg cggcggaaaa ggaacgagaa tgagtgaagt 700681 cacgaatgac attcctaaac cgctcgccat gataggcggc aaaccgattc tatggcatat 700741 tatgaaaatt tatcagtact acggagtaaa cgagtttatt ctgcttttgg gctataaagg 700801 agaaaaaatc aaggaatact ttctcgacta tgaatggaag cacaacagcc tgacactcga 700861 cagctctacg ggagaggtac agatgctggg gcagcctgaa acgtggaaaa ttacgttttt 700921 ggagactggg gtagatacgc tgacagccgg aagaatcttg caggcgaaag actatatcgg 700981 tgatgaaaca tttctgctca cctatggaga cgggctggcc aatatcaatc ttttccatct 701041 catcagctat catcagacaa aaggtgctgc cgcgactgtc accggcattg acaaagtctc 701101 gcagtttggc accttgacag ttgaggatgg catggcgaaa acattttctg agaagacatc 701161 aagtgatgga atcatcaacg gcggattctt cgttcttagt ccaaaggttt tcgattattt 701221 gccgaaggac gggaacacga tgttcgaaga tgaaccgctg aagaaccttg ccaaagatgg 701281 ggagcttgct gtgtaccgcc attacggatt ttggacggcc atcgatacgt ataaaaatct 701341 cttagaagtc aacaaaatgt ggaatcaagg acaacaagta tggaaggtat ggtgaattga 701401 tttgagtttc tggaaaaata aaaacgtatt tgtcacggga tgcacaggtc ttttaggaag 701461 ctatttggtg aaagagctga tcgaacaggg cgcaaacgtt acggggctag tcagggatca 701521 tgtgcctcaa tccaatcttt atcagggaga acatatcaag aaaatgaaca tcgtgcgggg 701581 ctctcttgag gacttggctg tgattgaacg cgcgcttggc gagtatgaga tcgacacagt 701641 ctttcatctt gctgcacaag cgattgtcgg cgtggcaaac cgcaacccga tttctacctt 701701 tgaagcgaat atcctcggca cctggaatat tctcgaagcc tgccgcaagc atccgttaat 701761 taagcgggtc attgtcgctt caagtgataa agcttacggc gatcaagaaa accttccata 701821 cgatgaaaac atgccgctgc aaggcaagca cccgtacgac gtctcaaaaa gctgcgcaga 701881 tctgatcagc cacacctatt ttcacacgta cgggcttccg gtctgcatta cgcgctgcgg 701941 aaacttatac ggcggcggag atttgaactt caaccgcatc attcctcaga cgattcagct 702001 tgtgctgaac ggggaagcgc cggaaatccg aagcgacggc acatttgtac gggactactt 702061 ctatattgaa gacgccgttc aggcttatct gcttcttgca gaaaaaatgg aagaaaacaa 702121 tcttgccgga gaggccttta acttcagcaa tgagatccag ctgaccgtac ttgaactggt 702181 agagaaaata ttaaagaaaa tgaacagtaa tctgaaacct aaggtgctga atcagggaag 702241 caatgaaatc aaacatcaat atttatccgc ggaaaaagca agaaagctgc tgaattggac 702301 accggcctac actattgatg agggacttga aaaaacgatt gagtggtata cggaattctt 702361 caaaaagtaa tgtgaaacga ggtgaacaag actgtgacca gcgcgtattg caccgtttta 702421 tcaaaaggaa gattatatca ggcagtcgct ttgtttaagt cgttagagca agttgatcaa 702481 gacagtccca tttttatact ttgcatggat gaagatacgc accgcgtgtt acagaagctg 702541 aagatgaagc agctgaacct tgtgccggtg gccgctcttg aaaatgaatt gctgctgaag 702601 ctgaaggaaa ctagagatca aagtgagtat tgctggacga tgaagccgat ctttctgcaa 702661 gctgtgctga acagcaatcc tgagctggag cgtgtgacgt atattgacgg ggatctcttt 702721 ttctatgcag atccatcgcc gatttttgaa aaccagccgg actgctcggt gttgctttca 702781 cgaggggata ttgtaatccc ttcttttgag aaagagcaga ttgacatgct gcagcgtctt 702841 ttaggcagat ataattccgg gtttatcagc ttcaagcatg atgatgcagg cacggattgc 702901 ttggagtggt ggaaggaacg ctgtcttgag gaatgcaaaa atgcaccggg tgaagggaaa 702961 ttcggtgatc agggctattt ggattatatg tctgagctgt ttccgaatgt gtgtgacatt 703021 acaacacccg gcgtgaacat cggccattgg aattatggac agcatacgtt ttcctggaaa 703081 gatggccgga tcgtgctgga ggatggcagt ccgctgatct tttatcattt cagcggatac 703141 cgaatcgtca gcatcaatga aatcaaacag attcatgaaa caacccgcac agatctgccg 703201 tttgtgcatg aactgtatca agagacactg ccgcatatca ttcagcacat gcaaacgtta 703261 gaccctgaat ttaacggttt tgcttcaaaa gatgacaaca aataaatgag taaatacagg 703321 aagtgaaaat gaagtgaaag caagcgttat tattcctgca tataattcga aggagcgtct 703381 ttacaacagc cttctgtcat taaaccagca ggagtgcgat gaagaatttg aagtcattgt 703441 agcggacaat ggctctgagg acgggacgct ctcgatgctt gagtcatttc aagctgattt 703501 tccgctgatc tttacacgga ttaaagaaaa caggggcatt gcgtacggac gaaatcaggc 703561 gcttcgcaat gccagaggag acatcctgat tttccatgac agcgatatgc ttgcggcaaa 703621 ggaccttgtg gcaaaacata ttaaagccca tgagaacgaa gagaatctcg tcgtgtgcgg 703681 gttgttttgg aaacggatct acagttttta ctatgaacga tttgaagaag aacataagga 703741 acagctcgca aagctcacag gtgaaatgcc gaagaaagac aaacaaaagc tgctggagga 703801 agcggacatc aaaaacggaa gctttcttga taaaagcttt gacctcgata ccgactttat 703861 agacgtgctc aagaagattt tagatgagta cggcgatgac ttgaaaggct atcatatgcc 703921 atggcgcttt tttatcacga ataattcctc tgtgaaacgc aagcatgtgg ttgacctcgg 703981 tttatttgac gaaggcattg tgcggtacgg gtttgaggat tatgacctcg ggatcaggct 704041 tcatcaggcc ggattgacct tcaggcttcg ccgtgatatt gtcagtgttc atcaggaaca 704101 tccaagcaat tgtaagtctg tagacgatat tcgggcaaac attgcctata tgtgcgataa 704161 atacaataac atccgctcct tagacgttca tctcgctttt aatgggccgt tcccgcctga 704221 catgacgaac agaatcatgg ctgatattca aaagctgctg gaatcacaga aatatgatat 704281 gctgctgaat ctgtttcttg agcttctgca tgttgttaaa gagcgcaaca ttgatccgga 704341 ttggcgaaag aaatccccaa gggtgacggc gaaaagcttt gatttgcaaa ctgtccgcaa 704401 gcttctgcct aaggcgaaga aaaagctagg cgtgaacgat tttgccaacg cactgtatgc 704461 gcttgtcaac gatttgctgc acgtggatct tagatcattg gatgtggtat aagtgagtac 704521 atttcatttt tcaacgatag tgtcaaggac acatatcttt aagctcatgc ctatgattca 704581 ttctctccat gagcattgcg atgattttca tttatatgtg ctgtgtgtcg accagaaagc 704641 gtatgaattg cttcagcacg ttccatggga gcatgtaacc tttgtgcagc tgcatgaaat 704701 ggaagacccg gagctgttga aagcgaaaag caacagaacg tttcatgaat attgctggac 704761 gttaaagccc gcctttttgt ttcatgtgat gagcaagtgg gatgacgctg aatactttgc 704821 ccatatggat acggatctat ttttcttttc tgatccggca cgtatttttg cagaaaaccc 704881 aacggcgtct ctgtatttga ctgatcatcg taattcgccg cgcttcatgt cctactacga 704941 ccgaaccgga cgctttaata caggctttgt cggcgccggt aatacaaagg aagcatatga 705001 agcggtgtgg cagtggagac aggactgtat tgaattttgc acggtcgaaa tggatacgga 705061 acgaaagaca tatggtgatc aaagatatgt ggagaaatgg ccggagcagt ttaaaggtgt 705121 tcatgttgtc aaatccatag gagccaatac agcgctttgg aatatcgaaa actataaggt 705181 cgggcaaaag gacggccgcg tgtatataga tgaaacgccg ctgattttct atcatttctc 705241 tgggtttacg ctggtgacag aaaaagagtt taatctttgc tggtactacc ggattgaaga 705301 cgaagcgaca attaagatga tttatatgcc ctatatatta aatctgaaaa gatggattga 705361 tgaaatacag tcggcgtttc cggactttgc ggatggcttt atcccgaagc acgcagtgcc 705421 tgacactcat tttatccagc tggattaaaa aaccccctgc cgcctggcag gggttttttc 705481 agctatgcca ttctctcagc ttctggtcac ttggcaatag gaaggcaagg atgccgagga 705541 cagggagaaa ggcaatggcg atcatcgtcg gggtcagtcc cgcggcatca atcagagcgc 705601 ccagcgccac agcgccgatt gcgcccatcc cgaaggcaag cccgacggtt aaaccggaca 705661 ttgtgccgat ttttccagga actagctcct gtgcgtagac gaccgttaca gaaaagctcg 705721 acatcagaac caagccaatc aatgcgagca cgccgtaggc gagaaccggg ccggcaaatg 705781 gcagcacaat cgccagcggc gccgagcata acagcgaacc gaggataacg aagcgttttc 705841 caaaacggtc tgcaagcggg ccgccgagaa acgtgccgat cgcgccgaac agcaagaaga 705901 caaaaatata gctttgtgcc tgctgaatgc ttacgtgata ggtatccatc gcgtaaaacg 705961 tgtaaaagtt accgatcgca ctcgtatacc aagaacgagc aaaaatgaga aatataataa 706021 taataagagc agatacaaca gatttggtga tggccgtgtt ttcagccgtt ttcttttgct 706081 tgcctgattt ctgggcaagg ctgccgagac gtgaggcgta ccatttcgca atatacatga 706141 gaaacataac agcaagcgcg gcgacaagcg tgaaccaaac agcgccgaat tgcccgagcg 706201 gcacaaggat cagcgcggtg atcagcggtg ccatcgcctg gcctgagttt ccgcccacct 706261 gataaatcga ttgggcgagc ccgcgttttg tgccggcggc catatacgcc acacgggagc 706321 cctccggatg gaaaatggcc gagcctaatc caatgaaaaa cacacagcat aagatcgtta 706381 tgaatgacgg ggcaaatgca aggcccaaaa tgccaagcat gctggcggtc aaaccgactg 706441 gcagcgcata cggccgcggc cgtttatcgg tataccagcc gacaacaggc tgcatgacgg 706501 atgacaccat gtttaatgtg aaagcaatga tgccgagctg tgtaaacgtc aggctcatgg 706561 agcgttccaa aatagggaac atggccggaa tcacagcctg aagcgaatcg ttgagcatat 706621 ggcaaattcc gataataatc aaaatcggat acaccgtggt gcctggtttt tgaactgttt 706681 tttcttttaa cggggcggcg atagccattg agtctcctcc ttacatatat aaccaaagca 706741 taccaccata ttattcataa ggtgaagaat ttatcaagag gaaaaaagat tcttatgaaa 706801 gaaataccgt cagcctgatt agcagctgac ggtattttcg atattcaaaa tgtgatatag 706861 ctcttcaagc ttacgaatct cataggttgg tatgatctct ggcacattcg gcttcatgtc 706921 agggttcatc cagcaagtat caagcccggc gagctgtccg cctttgatat cagcagttag 706981 tgaatccccg atgattaatg tgtgctctgc tgaaaattga ggaatccgtt caaacacgta 707041 attgaaatat tccttcatcg gcttttggaa gccggtgtct tcagaaacga aaatgtcctt 707101 gaagaatgga aataatcctg aatcacggag acgcttatat tgtgtgtgag acacgccgtt 707161 tgtcacgatg tacaaatcaa actgttgctg cagatttgag atgagatcaa atgcaccgtc 707221 aataagctga tgtccttctt caagaaagcg gcggtatttt tgctcaagca aagcgccgtc 707281 cgcttcgtaa ccgtactcct tgagcaaagc ggaaaaacgt gtgtttacga cttcatcccg 707341 tgtcatctta ccttcttcaa aggctctcca gagaccttga ttgatggttt tatactgcgc 707401 cttcatgtca tttgttaaag gaatgttctg atcttcaaac agcaaacgca gggctaaagc 707461 ttctgccgct tgaaaatcaa ggatggtatc atctacatca aataataaag tgcggtatcg 707521 cttcatctgt gtgtctccct ttctcatatg tattcaaagt atagcacata aaaaaaggaa 707581 aaagccggcg ggtgaggcac cgccggctga aaagagatta tttgtttaat aagctgtgtt 707641 ttctcgaata taggaagtaa accagcgttc cgacagcgat ccagatgaca aatgaaagcc 707701 atgtgacgcc gggaaggctg tacatgaacc aaaggcagat gcctgcgctg ataatcggca 707761 caaccggaac gaatggcact ctgaaggacg ctttgatttc aggatgtttc tttcttaaca 707821 caatgacagc aatggaaatg accgtaaacg cggcaagtgt tcccatgttc accagatggg 707881 ccagcgttcc gaggttaata aagccggcga ttcccgctgc aacgatccct gtcagccatg 707941 tgttgcggaa cggggtttta aatgacggat gaacctttgc gaacaatcca ggcagaaggc 708001 cgtctctgct catggcaaat gtcaagcgga cctgtgcgta cagcaaagcg agcatcaccg 708061 tcgtaatccc gataatcgca ccgacagaaa taattccggc aacagcgtcc tgtccgacga 708121 atttcagcgc aaaggataca ggatctccga cattcaattt ggcataaggc atcatgcctg 708181 tcagcacaag cgataccgcg atgtacagaa ccgtacagac ggctagagct gaaataatgc 708241 cgacgggcat gtttttttgc ggatttttca cttcctctga tgcgttagaa accgcgtcaa 708301 acccaaggta cgcgaagaat acagtggcag cgctaagtat gacgcctttc atcccgaatg 708361 gcataaaagg agaccagtta tccggtttca catagccgat gccgacaata atgaacaata 708421 atatgatcgc gattttcatc agtacgatga cgttgttaaa gcgtgtgctt tccttgacgc 708481 ctctgctgac aatcgcagtg atgaggagaa tgatcaccgc agccggaagg ttaaatacgg 708541 cgcccgccat gcttcccggc gctcctgtca gtgcagccgg aatatgaaga ttgaagccgg 708601 caagcagtga ttgaaagtat gaagaccagc cggtggcaac cgccgacagt gcaatgacat 708661 attcaagcat gagatcccat ccgatcaaaa aggcgagcag ctctccaagt gtcacgtatg 708721 agtatgagta cacgcttccc gaaatcggaa tggaagacga aaactcagca taacagaaag 708781 cagccagcgc acaggcgagc cccgctaaaa taaacgatat gatgagggcg ggacctgcac 708841 cggtcgctgc cactgttcct gtaatgacaa aaatccctgt accgatgaca caaccgatac 708901 cgagcaaggt taaatcaaat gcgcttaacg tacgggcaag gctttttgac ttgctctgcg 708961 cactcaatgt ttcaagcggt ttttttctaa ataatgaact catcaaaagt tcctcctaga 709021 aatattcaaa atattctaat cattatatgc agttcttgtt gtattatatt gtcgaaattt 709081 gacgtagtca ataaaatatt tttctgcttt aaatgataga agcgaaacag cgttgtcgta 709141 tcataggata gtaattttta ctaatcgtat attcaatttt atgcaagatg aaccgataga 709201 aaaaatagat tcgcccatat tttgatttgc ggttataaag gagatgctga ccatgtttca 709261 atatgaagag ttgaataaac agtttatcgg cgggaaatgg caggagggca gcagcccaaa 709321 tgtattggaa aacaaaaatc cttatactca aaaaacattc acaacattcc gtaaagcgac 709381 tgctgacgat gtagatgaag cgtatcgggc agcggcgctg gcaaagaaaa aatgggatgc 709441 ggtcaacccg ttcgagaaaa gaaccatttt agaaaaagcc gtcacgtata ttgaagaaaa 709501 tgaagaagcc attatttatt tgattatgga ggagctaggc ggtacaaggc tcaaagcagc 709561 ttttgaaatc ggtcttgtca aaaacatcat aaaagaagcg gcaacgttcc caatccgcat 709621 ggaggggaaa attcttccgt caacaataga tggcaaggaa aacagattat atcgcgtgcc 709681 ggcaggcgtt gtcggtgtca tcagtccgtt taacttccca ttctttttat ctatgaaatc 709741 agtggcgcct gcactcggag ccggcaatgg cgttgtgcta aagccgcatg aggaaacgcc 709801 gatttgcggc ggaacgctga ttgcgaaaat ttttgagaac gcgggaattc cagcggggct 709861 gctgaatgtt gttgtcacag acattgctga aatcggcgac agcttcgttg agcatccagt 709921 gccgcggatc atctcattta ccggttctac gaaagtcggc agctacatcg gacagcttgc 709981 gatgaagcat tttaaaaagc cgcttcttga gcttggcggg aacagcgcct tcatcgtact 710041 tgaggatgca gatatagaat atgcggtcaa tgcggcggtg ttcagccgat ttacacatca 710101 agggcagatt tgcatgtcag ccaaccgcgt gcttgttcat tcttctattt atgacaagtt 710161 ccttgagctg taccaggcaa aagtggaatc gctgaaagtc ggcgacccaa tggaccctga 710221 tacgattatc gggccattaa tcaacagcag acagacggac gggctgatga agactgtaga 710281 gcaagcaatt gaagaaggcg ctgtaccagt gaagcttggc ggatttaacg ggacgatcgt 710341 ggaaccgacg atcttaaaag acgtcaaacc gttcatgagc attgccaagg aagagctgtt 710401 cggaccagtc gtctccttta tgaagtttga ttcagaagac gaagcggtgg atatcgcaaa 710461 cgaaaccccg tttggcttga gcggtgccgt acatacgtca aatcttgagc gcggcgtggc 710521 ttttgcgaaa cgcattgaaa caggcatgat tcacgtcaat gacacgacca tcaatgatga 710581 accgaatgta gccttcggcg gtgaaaagca atcaggcctc ggccgtttaa acggtgagtg 710641 gagcctcgaa gaatttacaa cgctgaaatg gatctcggtc cagcacgaaa aacgcagctt 710701 cccttattaa tgaaaaggag tgaatggaat tgaccataaa tacggaaaaa gaaaccgcag 710761 atattctgga cgcatttatc aaagtagccc cttatttaaa cagcctggtt caggatgata 710821 ttacaatcgg catttatgat acggaaaaac tgctcgtgaa tataccggcc aaaacctttt 710881 cgctgaacgt aaaagccggc gatccgctgc aggaagggga tatcatcaca gatgccatcc 710941 gcagcaatca gaagaagacg agcatggttc cgaaagaatt gttcggcttc ccattgatcg 711001 cgcgtgccat cccgctgcac gacgagaatg gaagagtcat tggaggcgtc ggcctcggaa 711061 cgagccttga ggagtcgtca aagctgcatg atgtcgcgga aagcttatca gctgttgttg 711121 aacaaacagc cgcggctatt tccgacattt ctgaatcaat taacgggttt tcaactcaaa 711181 tgtcgggcat ttcctctcag gcgaaaaaag taagcgaaag cgccggtgaa atcgccgata 711241 tttcagtaac tgttaaaggc atctcggacc aaagcaatct gctcggcttg aacgccgcga 711301 tcgaagcggc aagagcaggg gagtccggaa aaggattctc tgtcgtcgca gatgagatca 711361 gaaagctagc gacgcattca aaagaaaatg tcggccaaat tgaccagatt acgaaaaaaa 711421 tccacagcct gctgaaaggg ctggaggaat ccattgagtc gattaaccag catacagacg 711481 gacaagccgc tgctgttgaa caaatttccg ccacgatgca ggagatttca ggaagcgcgc 711541 agcatcttgc gaaaatggcc gaaaaagcgc ttgaggaaga gtaagagacc ggggacaaac 711601 atccccggtc tttttcttat cctgcatttc catgaaattc gtctgacgtt ttactagttt 711661 tattccagcg gctgatttaa aatgtacaca tgaacttacg tgaggattga taggaaccat 711721 gagcatatta aaagcggaaa atctttataa aacatacgga gataaaacat tatttgacca 711781 tatctccttt catattgaag agaatgagag aatcggatta atcgggccga acggaacagg 711841 aaaatcaacg ctgttgaaag tgattgccgg cttggaatct atcgaagaag gagaaatcac 711901 gaaatccgga agcgtgcagg tcgaatttct tcatcaagac ccggagctgc ctgcggggca 711961 aacagtgctg gagcatatct attccggtga atcggctgtg atgaaaacct tgcgtgaata 712021 tgaaaaagcg ctgtatgaac tggggaaaga tcccgaaaat gaacagcgcc agaaacacct 712081 gctggcagca caagcgaaaa tggacgcgaa caatgcatgg gatgcaaaca ccttggcaaa 712141 aaccgtattg tctaagctgg gcgtcaacga cgtaacaaaa ccggtcaatg agctctcagg 712201 cggccagaaa aaacgggtgg ccattgccaa aaacttaatt cagcccgctg atttgctcat 712261 tttggacgag ccgacaaacc atttggataa tgaaacgatt gagtggcttg aagggtattt 712321 aagccaatat cccggcgccg tcatgctggt gacgcacgat agatatttct taaaccgtgt 712381 caccaaccgc atttatgagc ttgaaagagg cagcctctac acttacaaag gcaactatga 712441 agtgttttta gaaaaacgcg cggaacggga agcgcaggct gagcaaaagg aaacgaagcg 712501 gcaaaacctg ctgcgccgcg aactggcttg gctcagacga ggagcgaaag cccgctccac 712561 aaaacaaaaa gcgagaattg accgggtaga gacgcttaaa gagcagacag gccctcagtc 712621 atcaggttca ctcgattttg ccattggctc gcaccgtctc ggaaaacagg ttattgaagc 712681 ggagaacgtc atgatcgctt atgacggccg catgctcgtc gaccgtttta atgaacttgt 712741 cataccaggt gaacggatcg ggatcatcgg gccgaacggc atcgggaaaa caacgctgtt 712801 aaatgccctt gccggccgtc atacgccgga cggaggcgat attacgatcg gacagacggt 712861 cagaatcggc tactatactc aggatcatag tgaaatgaac ggtgagttaa aagtcattga 712921 ctatataaaa gaaacggcgg aggtcgtaaa aacggcagat ggcgatatga ttacagctga 712981 acaaatgctc gagcgtttcc tcttcccgcg ttcgatgcag cagacgtata tccgcaagct 713041 gtccggcggg gaaaaacgcc gtttatactt gcttcaggtt ctcatgcagg agccgaatgt 713101 cctgtttctc gatgagccga cgaacgattt ggatactgaa acattaagcg ttcttgagga 713161 ttatattgac cagttcccag gcgtcgtcat caccgtatcc catgaccgct atttccttga 713221 ccgcgtcgtc gaccgtttga ttgtatttga aggaaatggt gtcatttccc gctttcaagg 713281 ctcctatagc gactatatgg aggagtcaaa agcgaaaaaa gcggccccaa aaccggcagc 713341 tgaggaaaaa acggctgaag ccgagccgaa gaaaaaacgg aaaaagcttt cttacaaaga 713401 ccagttggaa tgggacggca tcgaagataa aattgcccag ctggaagaaa agcatgaaca 713461 gcttgaagct gacatcgccg cagcaggcag tgattttggc aaaatccaag agctgatggc 713521 cgagcaggcg aaaacggcgg aagagcttga ggctgcgatg gaccgctgga cagaattgtc 713581 cctcatgatc gaagaactgg aaagctaaaa agcgtggccg cagcaggccg cgcttttttt 713641 cacataatgg acaaaaacga accggcctgc ttatgttagg ataaagttgt gtgtcagcgg 713701 cacatggaaa actaacggag atgatgaagt atgacatggg cgatcgtgat gttaattctc 713761 atgagtctgg tgaaaatcgt attaacctgt cttcctacag gcgtcataga atggctgctc 713821 ggcaaatttg aagtgcacgc caagctgagt gacgaaaatg cgagtctctc tctagatgga 713881 aaacgcctcg agggtgcaga gaagcagaaa gtgattgatc aatttaacga agctatcttc 713941 ctggaaaaat attatatcta tccaggtgat gaagagcgtt atttacatcc ggaaaacggc 714001 ggcacgcctc tggtgataga tacaaaaaaa ggaaaaaaag acgtgaagct gttcgtgtac 714061 cgctacgacg accatatcga cgtcgtgaaa cagtacaaga agaaagtgat cgcgtatcga 714121 gtgctttctg aaagccttca aaaagagtct ctgtcagtgg cgggaagttt agcttaaaca 714181 ggaaagtgaa agacgggtgc tgtatgctgc tcgtcttttt tattgttttt taaaacttaa 714241 cgtttacgtt aaggttcaaa aggtgtataa tggtaacaga aacggcgaag ggggatttac 714301 cttggaatgg atgaagattg atcaagtggc caaaagaagc gggctgacaa agcggaccat 714361 ccggttttat gaagaaatcg gcttgattcc ggcgccgaaa cggacagacg gcggtgtaag 714421 gctttattca gaggatgata tggaggagct tgagaaagtc atcagcacaa aagaggtgct 714481 cggtttttcc cttcaggagc ttcagcattt catggaaacc agccgccagc tagagttaaa 714541 caaagagggg tatttgttgt cactggatcc taaggaacgg aaagaaaaac tggaggaaat 714601 tcaggaaacc ctgaatcacc agctggattt gattgatgag aaaatccgca cattccaaag 714661 ctttaaagaa cgcctgcagg gcatgaaagg caaagcggaa cgcgccattc aatcaatcga 714721 atgaaaagtt tgttaaacgc tatttttgta gcgtttcttt taatggaata aagatggagg 714781 ttaggtcaaa tggataagac aacacaagtg aatcagaaaa cgggtttgct cagccagcca 714841 aaagcggtat gggctgtcgc gtttgcctgt gtgatttctt ttatgggaat cgggctggtc 714901 gatccaattc ttccggccat tgccgcacaa ttgcatgctt cacctagtga agtatcactc 714961 ttgtttacaa gttatttgct tgtaaccgga tttatgatgt ttttctcagg agccatttcc 715021 agccgcatcg gcgcgaaatg gacattaatt ctcggactta tttttattat tgtgtttgcg 715081 gggcttggcg gcagctcaag ctcaatcgct cagttagtcg gctatcgcgg cggctgggga 715141 ttagggaatg ctttgtttat ttcaacagcg cttgcggtca tcgttggcgt gtcagtcggc 715201 ggcagcgccc aagcgattat tttgtatgag gccgcgctcg gtctcgggat ttctgtcggg 715261 ccgcttgcag gcggagagct cggaagcatt tcatggcgcg caccgttttt tggagtatct 715321 gtcctgatgt ttattgcgtt aatcgcgatt tctttcatgc ttccgaagct gccgaaaccg 715381 gcgaaacgcg tcggtgtgtt tgatgcgatg aaggcactca aatataaagg cctgctgaca 715441 atggcggtat cggcattcct atacaacttt ggatttttta ttttgctagc ttattctccg 715501 ttcgtactgg atttagatga acacggtctt ggatatgtct tcttcggctg gggccttctg 715561 ctggcgatta cgtcagtctt tacggcgccg ctcgtgcaca aagcgctggg cacagtgcgt 715621 tcgctagtcg ttctctttat cgcctttgcg gccattctcg ttattatggg gatctggaca 715681 gaccatcaga ctttgattat tacatgtatc gttgtcgctg gtgctgtcct cggtatggtg 715741 aatacgatca tgacaaccgc tgtgatgggt tctgcgccgg ttgaacgttc aatcgcgtct 715801 tcagcctaca gctcagtccg cttcatcggc ggcgcgctcg ccccgtggat tgcaggaatg 715861 ctgtcagaac actttactgc aagcacacca tatacagtag gcggaatcgt cgtttttgtc 715921 ggcatgcttg tccttctcat gggacgtaaa catcttgctg gaattaaggc ggggcattaa 715981 taacgaaaga cactgcgcat atgcagtgtc tttttattcg ttataatgca tcataatcga 716041 attggtgcag gaaaggacaa cctttatgac acaattttac tattttccgg ctgaaaactc 716101 cctttagaaa ccggtttttt cggtcagcaa gaacggcgtt cgcggaaagg gcatccgctt 716161 cggtcaggca ttgatgcggc tgggatttat cttgcagaag ctgagaatgt gtccgttcat 716221 ttacgattgc catttcagtg atggttcatg ctgtagaggg gacgtttgcc atggataagg 716281 caaaacctga cgaatatgat cagaaatgtt tagaaacgct ctatcaatac atacacagcg 716341 tcatgaaaaa cagcttttct cggtcgagtg gtttaccgct tgggaagatg aggaggattt 716401 tgagctgtct gccaaaagag agctgacact tgatgaattc acatctccat tgcagctcat 716461 tttaaaagac agagagcttt tgagaatcgt tcagaaaaaa tggcagtaaa aaacccgccc 716521 tttagcaggc gggttttttt ataaattaaa gcactttcgt cgtccaagac tcgcagttcc 716581 acgtttctgt cgcaatatcc atataaaagt ctggctcgtg ggaaatgagc agaatggagc 716641 ctttatattc tttcagggcg cgcttgagct cttccttggc atcggcatcc aagtggtttg 716701 tcggctcatc gagcaccagc aggtttgttt ctgagttgat tagcttgcac aatctgactt 716761 tcgctttttc gcctccgctt aatacggaga cgcggctttc gatatgcttt gtcgtcagcc 716821 cgcattttgc cagagcggca cggatttcat actgcgtata agaagggaat tcgctccata 716881 cttcttcgat gcacgtattg ttgtttgttt ccttgacctc ttgctcgaaa tagccggtat 716941 agatgtgctc accgcgttca acagagcctt cgagcggctg gatttcacca agcaaacttt 717001 tcagcaatgt cgtttttccg atcccattcg cgccgtaaag ggcgattttt tggccgcgct 717061 ccatgcggag gttgagcgga cgggacagcg gggaatcgta accgatcacg agatccttcg 717121 tttcaaaaat cagcttgcct gacgttctcg ccggcttaaa gtggaattcc ggctttggct 717181 tttctgccgc aagctcgatc atatccatct tatcgagttt cttttggcgg gacatcgcca 717241 tgtttctcgt gctgacacgc gctttgttgc gggcgacgaa atccttcagc tccgcgactt 717301 cctgctgctg ctttttgtag gccgcttcaa gctgctgttt tttcacctcg tagacttcca 717361 taaactgatg gtagtcgccg acataacgtg tcagctcttg attttcaacg tgataaatca 717421 ggttgatgac actattcaag aacggaatat cgtgggaaat caggatgaac gcgttctcgt 717481 attcctgcag gtagcgtttc agccattcaa tatgctgttc atcaagatag ttggtcggct 717541 catcgagaag cagaatttcc ggcttttcaa ggagaagctt agcgagaagg acctttgtgc 717601 gctgtccgcc gctcaaatcg gtgacatctc gctctaaacc gatatcgctc aaaccgagac 717661 cgcgggcgat ttcttccacc ttggaatcaa tgacataaaa atcattgttt gtcagcgcgt 717721 cttgaatgac gccgacttct tcaagcagct tctcgagctc gtcgggatca gcctcgccca 717781 ttttgttgta aatctcgttc atttcctctt ccatcgcaaa taaataatgg aatgcgtctt 717841 tcaggacgtc gcgaatggat tttccttttt ccagcacggt atgctgatca aggtatccga 717901 cacggacatt ttttgaccat tcgacttttc cctcatcagg ttcaagcttt ccggtaataa 717961 tattcatgaa ggttgatttt ccttcaccgt ttgcgccgat caagccgacg tgctcgcctt 718021 ttaacaggcg gaaggaaacg ttattaaaaa tggcccggtc cccgaaaccg tggcttaaat 718081 cctttacaga taaaatactc atgtttacac ctctatcgtt atcaaacacg cacaatcggc 718141 gtgtaatatt cacccttttg attataaagg aggattcgga atgttgaaag gtataggaaa 718201 gaaaaagaaa aattgcgttc cgggcgaggt tttgagatac tatggaatag atttcaggaa 718261 ttgaggagaa caaaatgacg caaacttggc catttttaca taatgcacaa tcatttatac 718321 aagagaattg gaatgcttcc ggctttcaaa agccaacccc tgttcaggag caggcagccc 718381 agctgatcat ggacggaaag gatgtcattg cagaatcgcc gacaggcaca gggaagacgc 718441 tggcgtatgc gctgccggtc ttggagcgga tcaaaccaga gcaaaagcat ccgcaggcgg 718501 tgattttagc gccttcccgt gagctggtca tgcagatttt tcaggtgatt caggattgga 718561 aagcgggctc agagctgcgc gcggcttcct taatcggcgg ggcgaatgtg aagaaacagg 718621 tcgaaaagct gaagaaacat ccgcatatca tcgtcggcac gccaggcagg gtgtttgaac 718681 tgattaaagc gaagaaactc aaaatgcatg aagtgaaaac gatcgtgctt gatgaaacgg 718741 atcagctcgt cctgccggag catcgcgaaa cgatgaagca aatcattaaa acaacattaa 718801 gagaccgcca gcttctatgt ttttctgcca cgctcaaaaa ggaaacagag gacgtgctcc 718861 gcgaattggc gcaagagcct gaggtgttga aggtgcagcg aagcaaggcg gaggcaggga 718921 aagtgaagca tcaatacctg atttgcgacc agcgcgacaa agtgaagctg ctgcaaaagc 718981 tgtcaaggct tgaaggcatg caggcactcg tatttgtgag agacattggc aacctgagtg 719041 tatatgcgga aaaactggca tatcaccacg ttgaactcgg cgttttgcac agtgaagcga 719101 aaaaaatgga gcgagcgaaa atcattgcca cattcgaaga cggagagttt cctcttttat 719161 tggcgactga cattgccgca cgcggtttag atattgaaaa cctgccatac gtgattcatg 719221 ctgatattcc agatgaagat ggctatgtcc acagatcagg acgaacaggc cgggccggaa 719281 aagaaggcaa cgtgctgagc cttgtgacaa aattggagga atctaagctg aaaaaaatgg 719341 cgaagaagct tggtgttgag ctgagtgaag ctgtgtatgc aggcggaaaa ctgaagacga 719401 aataaaaaga agggcgaaga gccctttttt tgttgtaaaa taatagaaaa gattttgcgc 719461 ggaggtggga aaatggcttc aatagacagg tttcaagtaa tgcaggagcc agagctgaaa 719521 atccttgaac actggtttga gaatgaggat accagacgga gaatggatgg gatgctgcta 719581 ttagatgagt ggtatgcacg agtaaataaa gataaacacg atactgtcat catggcgtat 719641 gatggacagc tgccggcagg gatggtcgtt attgagttcg gagaggagcg gacatatatt 719701 ggattgatcg tcaatccttt gtaccggctt aaagggtatg gaaaacagat actgcaaaag 719761 ctgatgaccg aacctgattt tactagcgtg cgagaatggg tggcatgcat tgaagaagac 719821 aatcgaatca gtttagcttg ctttcaagca gcaggattca ctttagaaga cacggaacct 719881 gatgaagatg gttttcttac gctgattctt cgcaactgat ctcatcgaaa cacaaaagga 719941 gggcaaaaag ccctcccgtt ttcatcttca ttcagctcgg atcactgacc ttgatcagct 720001 gtttcccttt attttctccc ttaaataaac cgagaaacgc gtcaggaatg ttttcgaagc 720061 cttctgtgat ggtttcctcg taatggagtt taccagcctt cagccattct gccagctgtt 720121 ttgctccctc agaaaaacga tcggagtagt cgcttacgat aaagccttgc atcagcgact 720181 tcgttttaat gagttttgat tggacacgag ggcccatgtc atctgcttcg ctttctgcgt 720241 tataggaaga aatggcgccg cacaccggaa tgcgggcaaa ttcattgagc agattcatca 720301 ccgcgtctga aatcggtccg ccgacattgt caaaatacac atcgacaccg tcaggacaag 720361 cgttttgaag cgctttttgg atatcatccg ctgttttgta attgatggct tcgtcaaact 720421 gaagctcctg ttttaaatag tcgatttttt catcagagcc cgcgatgccg acgactcgcg 720481 cgcctttgat tttggcaatt tgcccgactg ttgaaccgac ggctccggca gctcctgaga 720541 caaccacggt ttcgccttcc ttcgggcgtc cgatgtccag caatccgaag tatgctgtta 720601 agccggtcat tcccaaaatg ccgagatagg ccgaagcggg agcaaggctt gtatcaattt 720661 ttcgcaaggc agactcgctc acagcggaaa attcctgcca gctgagattt ccgatgacga 720721 tatcgccttt tttcagatga ttcccgtctg acacaacttc agcgataacc cctccagaaa 720781 gcgctttatc caaggcgaac ggctcaacat atgacttcgt atcctgcata cggccgcgca 720841 tataagggtc aaccgataca taaagcgttt tgacaagcac ttccccttgc ttgggttcag 720901 gaaccggaat ggtttcaaag cgaaagtctt catgaacagg aataccttgt ggacgtcttg 720961 ctaattgaat ttgctgctga gatgctgtca ttttcatcct cctatcactt ggttgacacc 721021 actgtaacat ggacaggaga ggaaatacaa aaggtaagct ggcatacaaa aaaggttata 721081 gatgagctta tgctttctac aagctctttt gttttaaaag ttctctttag tcatttatca 721141 ttattagaaa acagaacaga aaaagagctc ctgtacacct agctaagatt ggctagtgtg 721201 tatgtcgatt ctttttcata ttcttgcaag catctgcgag ggggagctta gtcgttcaca 721261 ttttgctttc gcatcaatct gcaatagcaa agtctatgcg atttttttac atcagcaaag 721321 atttgttcaa ttttttcctt ttatgccgag tttttctgaa acagataatt gatggtactc 721381 aaccattttc ttttggtcaa taaagtaatg tttacttatt aattaaacac gcgaaaaagc 721441 aaacgaaaac ataattaaat tttatatatt tattaaaagc ttatatgttt atttaccttt 721501 tttttgaatt gtaattgaga aaatccatat attgcggaca ctaataaaag aatacctgct 721561 gaaacataaa ctaaacgaac tccaaggaaa tctgaaatag cccctatagc cagaattgaa 721621 aacataaaaa tgaactgtac taaagaagac cttgcagaca ttatattaat tcgagtttgc 721681 tcggttgtta tgttctgaat aagtgtttct tgtgtaagat ctcttaatat ataagccggc 721741 cccataaaga gaaccaaaat tagagctaag tatgaattac ttataaaacc atatattaaa 721801 gttaaacttc catatgagac agcgccaatt aacataaaat taattaactt attttgaaat 721861 ctctccgaca gcttatatat tataaatccc cctatcatcg aacctaaata atatgctcca 721921 ttaataaatc cccaccatga ttctccttta tgcaagactt cgttaacgaa agctaaagag 721981 acagatccta tccaaatcat tcctgcccat gactcaatta aatccataat aataattgtt 722041 ctaagtttct tttggctaaa taaataccgc caaccactta ctatactctt attgggagaa 722101 tttttttcac gtatgacaga attagcgtgg ccatgtggta gacaaaataa aagagaaaga 722161 agagatgtaa acaacaaaaa gatagtaagt ataatggtat atccctcacc taaaaatgca 722221 attatgagac cacctaaaga ccagcctaca aattgaaaag tttggtccac tgtagataat 722281 aatccatttg cttttactct tctatcagga gagattattt cccctataat tgcacttttt 722341 aaaggtgaga accatccatt aaaaaaggaa atacagctaa taataataaa gactaaaatg 722401 agagtttgat tagagtaagt tcttaataaa gcatagaaca aacatattaa taacagcatt 722461 tgtatcaatt gagaaataat tattgtaaga ggcagtttta atcgaattgt tattaacggt 722521 aatatagcac ttccaaaaat acgaaaaata atacttatta atgtcaccat agaggcgatg 722581 gttgtcgaat tggtcatttt aaacaaaaac gaaatcacta ccatagtata tagagaaaaa 722641 cctaaatttg tagtggtctg gctaaataaa atagaataat aacctttact catatgtatc 722701 ctcccttgga ataatttttc tcggtaaaga gcttaaacat atttaaacac cttaaaacaa 722761 caaaagtaaa gaaaaaattt ccttgtaaac tatttacttt tattctattt attgttattg 722821 tttatttaag ttctctgact attctatcaa tattcaggga accacatatc ttattaaagg 722881 ggggaaaacc atgagaaaat taagaaaaaa ctggagaaaa tcgattgtta gcccggttct 722941 ttatactaat gaaaaatggt aaacacttag ggaatagcat ttaatgctat tccttatttc 723001 aacaaacaaa tcgggaggtt atcgtaattt gactctatta atgcaagatc ataaatcaat 723061 ttacaataaa gatatagaaa tattaattga agttgaagaa cttattactt ctgttccaga 723121 aaataaaaaa aatgatttta agagtttaat cgataataga attatgactc tactaaataa 723181 aattcaacac cctgtagcag cggaaaatgt gtttgggatg tgtattgctt atccgaatac 723241 ttacataagg tatagattaa ttgatttcgt tgaaaaatgg gtaccttatt tctctgctgt 723301 agaaactata atcaatctaa cccaggatcc ggatgattta gtttctttta aagctatgga 723361 tgtctgtgca aatcataaaa ttgaagaatc tgtagcatat ttgtcttcga ttattgatga 723421 tgtccgggag agtataagct accctaaaaa acctgtggga ttaggggccc aaaaagtatt 723481 aagtacatta ttagatatat tcggtgttga aaaacatgaa gagctagtaa tgctaaaaaa 723541 ttattttgat caaaatggta tacttcctaa taactttgac tttgaagaaa aaattcctca 723601 aagtctaata gaggaattcg aaaaaacaga agaagatggg atgattttaa ttccgggtgg 723661 cttttttgaa ttcggtttaa atgaaaatga aattcctgac aaaacattta attggaaaga 723721 tgctgttcct agacaaaaag tatggttacc tccatttttt atcgataagt atcctgttac 723781 aaataaagat tatgatatct ttaccgagtt catagaggaa aatgggcata tattctgtca 723841 tcctaatgaa ccgcagaata aacaacatag aagaaataca tattgggatg ataggtattt 723901 agataatcat cccgttacag gtatagattt ttatgatgca tttgcttacg caagatataa 723961 ggggaaagaa ttgccaaccg agtttcaatg ggaaaaagct gctcgaggcg aaaagggtaa 724021 tgtctggcct tggggagata aatttgatcc tgcaaaggtt caatatgctg gaagtcttta 724081 taatgaaccc attacttctt taaagtcctg gagagaaaat ttattaaaag ctcatgctga 724141 taaagaatta aatcatttaa caagtgatat ttttgaacaa aatggtgaaa gtccctatgg 724201 agtatgcggt atgatcggcg gaacatggga gtggactaga agtgagctta aaacaaagag 724261 agctttccac cctatttttg agaatgtacc atttaatagt gttaactcat ttgccgttct 724321 taaaggagga tcattcttct ctcatccagg cttaatgttc ccttctttta gagcaaaaga 724381 tattcctttc tgtcgacaca atgaaatggg gattagatgc gtaaagaata ttccagtata 724441 taaaattaga gaatcaatta atgggccaat tactaataaa gcaatttatt aatcattcta 724501 ggttagagac ttgataaaag tatactaaca ttgtgtagta atgttcagct tgtagaaaaa 724561 acaatgtttt ttctacaaga ttttatttta aatgcttttc aaaattatca gggattgaga 724621 atcagaaaaa gagccattaa gctcgatctt agctaggtat tacgatcttc tgtatattat 724681 tgtgagaaat atagaagatt cagttagtta gcatttcgat tttaagctga gcctgcaata 724741 gcaaagcatc tgttttgatt attctttttc tgatacataa gctaattttg tcgcttttct 724801 tttttgtctt ttcacgcatt tcgaggatga cttactataa ttctttcagc ttttctatgt 724861 gttaagattc gaatagatga aataacttta acaagttggt caataagaac agatttaact 724921 ttatgttaaa agagtatctc gtatagaaca taagaagaat gacgagtttt ttaagattat 724981 catcaattat gtgagaataa aatattataa gggaaaatga aggctgtcac gtttctcgac 725041 agccctaggg aattcctctc cttttcattt cgcccgtaat ttcgggcaca gtcccgtcgg 725101 caggcacatt ggcttctggt cgatcgggct tctcatgatg cagcattcca agccgaagac 725161 ttcacggaaa aatggctggg tgaacacatc ttccggtgtt ccggcgttgt atatttttcc 725221 gtccagcaca ctgatcagat agtcagcata ttgagcggct tggtttaaat catggagcac 725281 catgacaacg gtgcggccat ggtcgcggtt cagctttttc agcagttcaa gcacttcaat 725341 ctgatgtgag atgtctaaat acgtggtcgg ctcatcaagc aaaagcaaat cagtgccttg 725401 cgcaagtgcc atggaaatcc aggctctttg tctttggccg cctgagaggg catcaagtgt 725461 ccgatccttc agttcaatca tgcccgttgc ttccagcgcc cactctacca tgtcatgatc 725521 ctcttgggta tgcttggata acagcttttt gtgaggatgt ctgccaaaat agcataattc 725581 ctctaccgtc aatccttcag gagcctgagg agattgtgga agaatggcca gtttttttgc 725641 gacttctttt gatggctggc ggtggatgtc ttttccttct agtagcactg taccgctttt 725701 tggggccatc agcctggcga gcgatttgag gattgttgat ttaccgcagc cattagcgcc 725761 gatgagcgca gtgatttttc cttcttctat ctttaagtcg actccgtcaa taatcactgt 725821 actgtcatat gaaagagtga gctggtctgc agccagtttt cccatggtat cctctcccta 725881 ctgtttcctc gcttcgaatt tcaataaata taagaaataa ggcgcgccga tcacggctgt 725941 cagtattccg gcaggtattt caaccggagg catgatgccg cgccctaacg tatctgcaat 726001 taataatata atagcaccaa tcaatgccga tgcaggcagt aaatatttag ctttttctcc 726061 ggtaagccgt ctggcgatat gcggagcaag caagccgata aaaccgattg agccgacgac 726121 ggctacacag cttcccgcca gcgccaccgc ggtgaaaatc aggatgaatc tcagccggtt 726181 tgcgttttct ccgagaccct gtgcaagctc atccccgagt gacataagat ccagcttcgg 726241 tatgagtatg cagacgatcg gaaaaagaat caaaagccat ggcgcaagca gcttgacttc 726301 ttcccagttt cttccccaga ggcttcctgt cagccaaatg agtgcagcat tcacgtcgcc 726361 tggaaacttg accatcatat attgcattcc ggcgtggcag accgcgccta aagcaatgcc 726421 tgataaagcc agtgaagagg gctgaatgct cttttttcgg gctatcatta ataatagtac 726481 agcaataatg gcggctccgg caaatgcgga gaacggaagc acgtataccg gcgactcagg 726541 aaagatgaga atcacagcca tcgccgcaag tccggagcct tttgaaatgc cgacaacgtc 726601 cggggaagcg agcggatttc ggatcacacc ctgtaaaatc gctccggcag cggcaagtcc 726661 agcacctgcc aaaatcgcta atataatgcg gggaaggcga tattgctgga tgataaattc 726721 aaaggaatga tccagtccca gcagattcgt cactaccgca tcaggtgaaa tgtataatgc 726781 accgattcca atgctgatga cggacagaac gattaaaatc acggccaata tgagtatcgc 726841 cagtaagggg cgtttttgtt ttctggttgt tttcttcatt tcaggtttcg ccctttcctt 726901 gccaaatata agaaaaacgg cgttccgata atcgcggtga caatgccgac cggtgattca 726961 taaggaaatg caatccatct ggccagaaca tctgcgtaca ccagcaaaat ggcaccgaac 727021 agtgccgaaa acggaagcac gtattgataa tgttctccga tcagcttgcg gacaatatgc 727081 gggacgagca gcccgacaaa gccaatcggc ccggcgacgg ctacggaagc gccggaaaga 727141 attaaaataa tcaaactgat cagaatcctg atgccgttca tattttgtcc aagccctttt 727201 gctgtttcgt ctccgagacc gagaacagaa acagaaccgg aaaatacgag ggcaagcccg 727261 atgccaatga cagaaaaagg agcgatggtt atgacgtcct gccagttgct gccgtcgatt 727321 gcgcctgtca tccagtacag aacatcctca cctgactcat ttaaaataat gatggcctgt 727381 gtcatagagg agaggaacaa gtgcacggcc attcctgaca gcgccagctt gacaggcgtc 727441 attccgccgg atgaggcaat catatacaca atcgcgccgc ctgctgccgc acccgcaaaa 727501 gcgaatataa cagatgaata gggcgatgcc ggcagaatga cgagagaagc aacaacaaaa 727561 agcgatgcac ccgcattcac accgaaaatt tggggtgaag ccagaggatt tctggtcata 727621 gcctgcatca gcgcccctgc tacagctagg ctggcgccga caaaaacgcc gattaatgtg 727681 cggggaaggc gaagagtaga gatgatgagc tgttcctttg aaccgtccca tacaaaaaga 727741 tatttcaatg aatctatgat gctgatgtct gaggctccta ctgaaagatt cagcccaagc 727801 ccaaatataa aaataatcag tgcaatgata aacatcatca gtcttgatga tgagcgccgt 727861 ttggctgaat gatacaacag tctcacttcc ttactgcgtc tggttgcaaa aacgaagaag 727921 caaggattcc cctcgcttct catttgtcct atttattata cactttttta agcacatctt 727981 tggcgcttgt ttcactagac ttgatgcctc tgaatcttgt ccaagtgtca cggtccgcat 728041 catagacttg tccatttttc accgctttga gatttttcca gagcgggttc gttttccact 728101 catctacaat ggttttgcct tcgttggctg agatgaacaa aatatcagga tcgattttgc 728161 tcaattgctc aaggctgacc tcttgatagg cgttatctga cttcacagcg tgtgtaaagc 728221 ctagcatttt aaagatttct ccgtcatagg atgatgatgt atgaagctgg aaggaatccg 728281 ctcttgcaac gccgagaacg atgttgcggt tttcatcttt cggaagttcg gcttttagat 728341 cgttgatgac ttttttgtgc tcggcaagct tttcttttcc ttcatcttct ttatttaatg 728401 ctttagcaat ggtcgtaaag ctgtcgatcg tttcgtcata tgtcgcttca cggcttttta 728461 attcaatcgt cggggcgatt tttttcagct gtttataaat gtttttatgg cgctcagcgt 728521 cagcgatgat taaatcaggc ttcaaggaac tgatgacctc aagattgggt tcgctgcgtg 728581 tgcctacaga tgtgtaatca atggagctgc cgacaagctt tttaatcata tcttttttgt 728641 tgtcatctgc gatgcccacc ggcgtaatgc cgagattgtg aacggcatcc aagaatgaaa 728701 gctcaagcac aaccacccgc ttaggtgtgc cgcttactgt cgtttttcct tcttcgtcat 728761 ggatcactct ggaatcctta gactcgcttt tgccgcttcc gttgttattc tggcttgatg 728821 aacagccgga tacaatgagg caggcgagca ataaaacact catgatggca atcaacttgt 728881 tagaataggt gcgcatgtca ttcttccttt tttcagattt agtaatgaga atcattatca 728941 catgtaacac tataatagca tggcttatca tgtcaatatt tttttagtaa agaaagctgc 729001 gtttttactg ctttctcatg aaagcatcat cagacacaaa taagtggtat gcagcgttac 729061 cgtgtcttcg agacaaaaac gcatgggcgt tggctttaga ggtttcgaac atatcagcag 729121 tgacataagg aaggagagtg ctgagataac cggacaattt cttttctatt tcatctgtta 729181 gtgcaaattc aatgtcgccg atattcatga taatcgagaa aacaaagtcg atatcgatat 729241 gaaaatgttc ctcggcaaaa accgcaagct cgtgaattcc tggtgaacat ccggcacgct 729301 tatggaaaat ctgtttgact aaatcactca caatccaagc attgtattgc tgttctggtg 729361 aaaagtattg cattagacat acctcctgct cgtacggata aaggcagcgt ttcatggtcg 729421 tgtgctccgt gcagcggctt ctccttaatt ttgatttttc tgaaaatagg tcccgttcct 729481 atcactttac catggacgga aaacaaatag ctactaccat tcctcctgtt tttctcttca 729541 atgttctgga atctgtttca ggtacagacg atcgggtatg aaagaaatat agaaaacatg 729601 aaggaggaat atcgacatga aaccagttgt aaaagagtat acaaatgacg aacagctcat 729661 gaaagatgta gaggaattgc agaaaatggg tgttgcgaaa gaggatgtat acgtcttagc 729721 tcacgacgat gacagaacgg aacgcctggc tgacaacacg aacgccaaca cgatcggagc 729781 caaagaaaca ggtttcaagc acgcggtggg aaatatcttc aataaaaaag gagacgagct 729841 ccgcaataaa attcacgaaa tcggtttttc tgaagatgaa gccgctcaat ttgaaaaacg 729901 cttagatgaa ggaaaagtgc ttctctttgt gacagataac gaaaaagtga aagcttgggc 729961 ataaagcaag gaaaaaacca aaaggccaat gtcggccttt tggttttttt gcggtctttg 730021 cggtgggatt ttgcagaatg ccgcaatagg atagcggaac attttcggtt ctgaatgtcc 730081 ctcaatttgc tattatattt ttgtgataaa ttggaataaa atctcacaaa atagaaaatg 730141 ggggtacata gtggatgaaa aaagtgatgt tagctacggc tttgttttta ggattgactc 730201 cagctggcgc gaacgcagct gatttaggcc accagacgtt gggatccaat gatggctggg 730261 gcgcgtactc gaccggcacg acaggcggat caaaagcatc ctcctcaaat gtgtataccg 730321 tcagcaacag aaaccagctt gtctcggcat tagggaagga aacgaacaca acgccaaaaa 730381 tcatttatat caagggaacg attgacatga acgtggatga caatctgaag ccgcttggcc 730441 taaatgacta taaagatccg gagtatgatt tggacaaata tttgaaagcc tatgatccta 730501 gcacatgggg caaaaaagag ccgtcgggaa cacaagaaga agcgagagca cgctctcaga 730561 aaaaccaaaa agcacgggtc atggtggata tccctgcaaa cacgacgatc gtcggttcag 730621 ggactaacgc taaagtcgtg ggaggaaact tccaaatcaa gagtgataac gtcattattc 730681 gcaacattga attccaggat gcctatgact attttccgca atgggatccg actgacggaa 730741 gctcagggaa ctggaactca caatacgaca acatcacgat aaacggcggc acacacatct 730801 ggattgatca ctgtacattt aatgacggtt cgcgtccgga cagcacatca ccgaaatatt 730861 atggaagaaa atatcagcac catgacggcc aaacggatgc ttccaacggt gctaactata 730921 tcacgatgtc ctacaactat tatcacgatc atgataaaag ctccattttc ggatcaagtg 730981 acagcaaaac ctccgatgac ggcaaattaa aaattacgct gcatcataac cgctataaaa 731041 atattgtcca gcgcgcgccg agagtccgct tcgggcaagt gcacgtatac aacaactatt 731101 atgaaggaag cacaagctct tcaagttatc cttttagcta tgcatgggga atcggaaagt 731161 catctaaaat ctatgcccaa aacaatgtca ttgacgtacc gggactgtca gctgctaaaa 731221 cgatcagcgt attcagcggg ggaacggctt tatatgactc cggcacgttg ctgaacggca 731281 cacagatcaa cgcatcggct gcaaacgggc tgagctcttc tgtcggctgg acgccgtctc 731341 tgcatggatc gattgatgct tctgctaatg tgaaatcaaa tgttataaat caagcgggtg 731401 cgggtaaatt aaattaagaa agtgaaaaac acaaagggtg ctaacctttg tgttttttaa 731461 ttaattaaaa tgtttattaa cttagttaag gagtagaatg gaaaagggga tcggaaaaca 731521 agtatatagg aggagaccta tttatggctt cagaaaaaga cgcaggaaaa cagtcagcag 731581 taaagcttgt tccattgctt attactgtcg ctgtgggact aatcatctgg tttattcccg 731641 ctccgtccgg acttgaacct aaagcttggc atttgtttgc gatttttgtc gcaacaatta 731701 tcggctttat ctccaagccc ttgccaatgg gtgcaattgc aatttttgca ttggcggtta 731761 ctgcactaac tggaacacta tcaattgagg atacattaag cggattcggg aataagacca 731821 tttggcttat cgttatcgca ttctttattt cccggggatt tatcaaaacc ggtctcggtg 731881 cgagaatttc gtatgtattc gttcagaaat tcggaaaaaa aacccttgga ctttcttatt 731941 cactgctatt cagtgattta atactttcac ctgctattcc aagtaatacg gcgcgtgcag 732001 gaggcattat atttcctatt atcagatcat tatccgaaac attcggatca agcccggcaa 732061 atggaacaga gagaaaaatc ggtgcattct tattaaaaac cggttttcag gggaatctga 732121 tcacatctgc tatgttcctg acagcgatgg cggcgaaccc gctgattgcc aagctggccc 732181 atgatgtcgc aggggtggac ttaacatgga caagctgggc aattgccgcg attgtaccgg 732241 gacttgtaag cttaatcatc acgccgcttg tgatttacaa actgtatccg ccggaaatca 732301 aagaaacacc ggatgcggcg aaaatcgcaa cagaaaaact gaaagaaatg ggaccgttca 732361 aaaaatcgga gctttccatg gttatcgtgt ttcttttggt gcttgtgctg tggatttttg 732421 gcggcagctt caacatcgac gctaccacaa ccgcattgat cggtttggcc gttctcttat 732481 tatcacaagt tctgacttgg gatgatatca agaaagaaca gggcgcttgg gatacgctca 732541 cttggtttgc ggcgcttgtc atgctcgcca acttcttgaa tgaattaggc atggtgtctt 732601 ggttcagtaa tgccatgaaa tcatccgtat cagggttctc ttggattgtg gcattcatca 732661 ttttaattgt tgtgtattat tactctcact atttctttgc aagtgcgaca gcccacatca 732721 gtgcgatgta ttcagcattt ttggctgtcg tcgtggcagc gggcgcaccg ccgcttttag 732781 cagcgctgag cctcgcgttc atcagcaacc tgttcgggtc aacgactcac tacggttctg 732841 gagcggctcc ggtcttcttc ggagcaggct acatcccgca aggcaaatgg tggtccatcg 732901 gatttatcct gtcgattgtt catatcatcg tatggcttgt gatcggcgga ttatggtgga 732961 aagtactagg aatatggtag aaagaaaaag gcagacgcgg tctgcctttt tttattttca 733021 ctccttcgta agaaaatgga ttttgaaaaa tgagaaaatt ccctgtgaaa aatggtatga 733081 tctaggtaga aaggacggct ggtgctgtgg tgaaaaagcg gttccatttt tccctgcaaa 733141 caaaaataat ggggctgatt gcggctctgc tggtctttgt cattggtgtg ctgaccatta 733201 cgttagccgt tcagcataca cagggagaac ggagacaggc agagcagctg gcggttcaaa 733261 cggcgagaac catttcctat atgccgccgg ttaaagagct cattgagaga aaagacggac 733321 atgcggctca gacgcaagag gtcattgaac aaatgaaaga acagactggt gcgtttgcca 733381 tttatgtttt gaacgaaaaa ggagacattc gcagcgcctc tggaaaaagc ggattaaaga 733441 aactggagcg cagcagagaa attttgtttg gcggttcgca tgtttctgaa acaaaagcgg 733501 atggacgaag agtgatcaga gggagcgcgc cgattataaa agaacagaag ggatacagcc 733561 aagtgatcgg cagcgtgtct gttgattttc tgcaaacgga gacagagcaa agcatcaaaa 733621 agcatttgag aaatttgagt gtgattgctg tgcttgtact gctgctcgga tttattggcg 733681 ccgccgtgct ggcgaaaagc atcagaaagg atacgctcgg gcttgaaccg catgagatcg 733741 cggctctata tcgtgagagg aacgcaatgc ttttcgcgat tcgagaaggg attattgcca 733801 ccaatcgtga aggcgtcgtc accatgatga acgtatcggc ggccgagatg ctgaagctgc 733861 ccgagcctgt gatccatctt cctatagatg acgtcatgcc gggagcaggg ctgatgtctg 733921 tgcttgaaaa aggagaaatg ctgccgaacc aggaagtaag cgtcaacgat caagtgttta 733981 ttatcaatac gaaagtgatg aatcaaggcg ggcaggcgta tgggattgtc gtcagcttca 734041 gggagaaaac agagctgaag aagctgatcg acacattgac agaggttcgc aaatattcag 734101 aggatctcag ggcgcagact catgaatttt caaataagct ttatgcgatt ttagggctgc 734161 ttgagcttgg ggagtatgat gaagccattg atctgattaa agaggaatat gcgatacaaa 734221 atgaacagca tgatctttta ttccataaca tccattcgca gcaggtgcag gccattttgt 734281 tagggaaaat aagcaaggca tcggaaaaga aggtcaagct ggtgattgat gagaacagct 734341 cactcgcgcc tcttcctgcg catatcggct tgtcccatct tattacgatt attggcaatt 734401 taattgataa cgctttcgaa gctgtagcgg agcaaagcgt gaaggaagtt ttgtttttta 734461 tcacggatat gggccatgac attgtcattg aagtatcaga cacagggccc ggtgtgccgc 734521 cagagaaaat agaagctgtg tttgagagag gctattcttc aaaggggatg aggagaggct 734581 acggtctggc caatgtgaaa gactcagtgc gtgaactggg cggctggatc gaactggcga 734641 atcaaaaaac tggcggggcg gtattcactg tatttatacc gaaggagaaa caaaggggga 734701 atccatttga ttcacatcgc gattgcggag gatgattttc gagttgcgca aatccatgag 734761 agattgatta aacagcttga tggattcaag attatcggca aggcggctaa cgcaaaagag 734821 acattggcgc ttttgaagga acacaaggct gatttgcttc tgctggatat ttatatgccg 734881 gacgagcttg ggaccgcgtt gattcctgat atacgaagcc gatttcctga agtggacatt 734941 atgattatca cagcggcaac agaaacccgt catttgcagg aagcgctaag ggcgggaatt 735001 gcccactatt tgatcaaacc cgtaacagct gacaagttca ggcaggtgct gcttcagtat 735061 aaagaaaaaa ggaagctgct catgtctcag ccggaggtca gccaatccat gatcgaccat 735121 atttttggga acggtgtgaa gacagctttg ccggcagagg atttgccgac tggcattaat 735181 tcgattacac tgcgaaaaat taaggaagcg cttcagactg cgtcagaagg attgacagcg 735241 gaggaacttg gggaaaaaat gggggcgtca cgaacaactg cccgccgtta tgccgagtac 735301 cttgtgtcaa aggaagaagc aagagccgag cttgaatacg ggattatcgg caggccggag 735361 agaaaatatt atttggcggc ggattagata tgaaaaaatc tataatccta ttgaatattc 735421 tattgatctt tatgcagggt gatatcaggc aggcggctgc gccgcgcctg ccggacgggc 735481 cgatagaaat tgtcgtccct gccgaacctt ctggcggctg ggatgtcaca gcgcaggcga 735541 tccaatcagt tttgaggcag aagcagatcg tgaaggatga tgttcatatc gtctataaat 735601 ccggcggcgg gggagagaaa ggctggaaat atgtcaacaa aagcagcaaa caaaccatca 735661 gcatgacgtc cagcctaata ttgagcaatg atcttctcgg gcaaagcaaa ttaaaaatgt 735721 ccgattttac gccgctcgcc attctctcca aggaatggca gacggttgca ttgccaaaag 735781 gatcagcgtt aacaaatggc aaggatgtgc tgaatgagat caacatgcat cccggcaagg 735841 tgagaatcgg ctttgccccg gggtttggca atgatgatca gctctcgttc gtcagagcgg 735901 cagatatgta cggcattgac ccgtttgaca ttcaattctc acagtatgac agcagcgaac 735961 agctcattca ggcgctgatc agacatgaga tagaagcggc ttccatgaca ctttctgaag 736021 cgaaaccata tgaacgaaac ggcgatatca cgttagccgc tgtaacgtct gataaaagac 736081 ttcccggttt tccaaatgta ccgacgtgga aggagcaggg aatcccgttt gttttttctc 736141 attggagagg gattttgggc ccgaaaaata tgtctgagga agagatttct tactgggatc 736201 aagcgctaaa gaaggtcacc tcctcacctg aatggaagcg gaaaataaac gaacaggact 736261 gggaaagctt ttatttaaac agcagggaaa cgaaacggtt tttagaagag caatctgctt 736321 tttatcaaag catcatgaca ggaaattaaa atcccgacat cccgggattt ttttcatgcc 736381 gaaaattgat caaaaagaac aaaacggttt taaaaaatta aaaatacaaa aaaaccaaat 736441 tatttacttg cggttggttt tcccatacga tggcaaaaag gcaagacaaa aaggggagta 736501 agggagaaaa aaatgtaagc ggattcattt aagggggaat ggatgtgtta gcaatcttag 736561 gctttctcat gatgcttgtg tttatggcat tgatcatgac aaaacggctt tctgttttaa 736621 cagcattagt tttgacgccg attgtgtttg cgcttatcgc cggatttgga tttactgaag 736681 ttggggacat gatgatttcg gggattcagc aagtcgcgcc gactgcggtc atgattatgt 736741 ttgcgatctt atattttgga attatgattg atacaggcct gtttgatcca atggttggca 736801 aaattttaag catggtcaaa ggagaccctt taaaaattgt tgtcgggaca gcggttctta 736861 caatgctcgt cgccttggac ggagatggct cgacaacgta catgattacg acaagcgcca 736921 tgcttccgct ctatttgctg ctaggcatcc ggccaattat cttggcagga atcgcgggag 736981 tcggcatggg aatcatgaac acgattccat ggggaggtgc gacgccgagg gcggcgagtg 737041 cgctgggggt tgatccagct gagcttacag ggccgatgat tcctgtcatt gcaagcggga 737101 tgctttgtat ggtggcagtt gcgtatgtgc ttggaaaagc ggaacgaaag cgccttggtg 737161 tgattgaact gaaacagcca gccaatgcca atgaaccggc tgctgcggtt gaagatgagt 737221 ggaagcggcc gaagctttgg tggttcaatt tattgttaac gctttcttta ataggatgtt 737281 tagtatcggg taaagtcagt ttaaccgtac tgtttgtcat tgcgttttgt attgcgctga 737341 ttgtgaatta tcccaatctc gagcatcaga gacagcgcat cgcggcgcat tccagcaacg 737401 tgctggctat cggttcaatg atttttgctg cgggggtgtt cacggggatt ttgacaggca 737461 cgaaaatggt tgatgaaatg gcgatctcgc tcgtgtccat gataccggaa caaatgggcg 737521 gattgatccc ggcgattgtt gccttaacaa gcggcatttt cacatttttg atgccgaatg 737581 acgcgtattt ctacggggtg ctgccgattt tatcagaaac agctgtcgca tacggtgtgg 737641 ataaagtgga aattgccaga gcctctatta tcggccagcc gattcatatg ctgagtccgc 737701 ttgtgccatc cactcatttg cttgtcggac tcgtcggagt ttctattgat gaccatcaaa 737761 aattcgcatt gaaatgggcg gttctcgcag tgatcgtcat gacggctatc gctctattga 737821 tcggtgcgat ctctatttcc gtatgataat tcaggcgtaa tgacacacac taacggcata 737881 caacattccg gaggtgtcat tatgagtgat ccttatatgc cgctgacttc agtcagaagc 737941 ggagcggggt tcgaagcggc aaaaggggtg cacggcctga ctgtgcaaat tgcgaatgtc 738001 tattttattc agctgccttc tgaacctcac tcatttgttt taattgatgc cggcatgccc 738061 caatcagccg gcgtgattgt caatgaagcc aaacaaagat tcggtgaagg gtttcagctg 738121 aaggcgatta tcctcacaca cgggcacttt gaccatattg gggcaatcga agagatcctt 738181 gagcattggg atgtgcctgt ttatatccat tctcgggaaa tgccttatgt aacaggtaaa 738241 gaggattatc ctccggctcg tcctgacagc aagagcgggc tggtcgctaa gctgtcgccg 738301 ctgtttccgc ggcactctat cgatatttcc tcacatgtcc aggcactgcc ggaagacggt 738361 tcagttcctt ttcttgacga gtggatgtgg atcgcgacac caggacacac gccgggccat 738421 atttcgttat tccgcgatga cggccgcgtg cttgtggcag gtgatgctgt tattacagtg 738481 gaacaggaga aaatggctga cgtcttgata caaaaacagg agcttcacgg gccgccggct 738541 tatttcacgc ctgacacaga gacggccgct gagtccattc taaagctggc cggtcttgaa 738601 ccggaagcgt tattgaccgg gcacggcata ccgatgaccg gcaaaaactt tcgaagtgac 738661 ttaactgaat tggcaaatcg gttatcgtct atttgacacc cgcaccacgc gggtgttttt 738721 tattgttttc caggaagttg cagaaaaatc atttgtcttg ccgcttaaaa acgatacaat 738781 gaaaagcatg aagtgatgtg aaggggagag tttgttggaa gaaaaagaaa tactctggaa 738841 cgaagcgaaa gcgtttattg ccgcatgcta tcaggaattg ggaaaggagg aggaagtgaa 738901 agaccgtctc gcggacatta aaagtgaaat tgacctgacc ggaagctatg tacatacgaa 738961 ggaagagctg gagcacggag cgaaaatggc ttggagaaac agcaaccgct gcatcggcag 739021 attgttctgg aattcgctga atgttatcga cagacgagac gtccggacga aggaggaagt 739081 gcgtgatgcc ctctttcacc atattgaaac cgccaccaat aacgggaaaa tcagaccgac 739141 cattacgatt ttccctccgg aagagaaggg tgaaaagcaa gtcgagatct ggaatcatca 739201 gctgatccgg tacgctggat atgagtcaga cggagaaaga atcggcgacc cggcttcctg 739261 ttccctgaca gcagcctgcg aagagctcgg ctggcgcgga gagcgaacgg attttgacct 739321 gctgccgctc atttttcgca tgaaagggga cgagcagcct gtctggtatg agctgccgcg 739381 ttcacttgtg attgaggttc caatcacaca tccggacatc gaggcgtttt ctgatttgga 739441 gctgaagtgg tacggcgtgc ctattatttc tgatatgaag cttgaggtcg ggggcattca 739501 ttataatgcc gcgccattta acggctggta tatgggcacg gagatcggag cgagaaacct 739561 cgcagatgaa aagcggtacg acaagctcaa aaaagtagcg tccgtgatcg gcatcgccgc 739621 tgattacaat acggatttat ggaaggatca agcgctagtt gaattgaata aagctgtgct 739681 gcactcgtat aaaaagcagg gtgtcagcat cgttgaccat catacagcgg caagccagtt 739741 taaacggttt gaagaacagg aggaagaagc gggcagaaag ctgacggggg actggacgtg 739801 gctgattccg ccaatttcac ccgctgccac tcatatcttc caccgctcct atgataactc 739861 aatcgttaag ccgaactatt tttatcaaga taagccttat gagtaaacaa tagaaaatcg 739921 atgatggcct tcaaggctgc gggattcagt cacagagatg tcggtaacct ttgagaaagg 739981 gcttccgttc tttacagcct caacaaacga ttgcagggcg ttttccggac cctctgccaa 740041 aatctcgaca cgcccgtcat cacggttttt gacccagccg gccagttttc gcttatcagc 740101 ttccatttga acaaaatagc gaaagcccac accttgaacc cggccgtcta caatgattcg 740161 gtattgaagc atgtaaaaac caccttttct ttttatgata atcaatcatt ttacaacctg 740221 taaaggggat gtgtttgtat gaaacaagag cgctattcag ttctttctct taatctggga 740281 aaaccgcaga cgcttgaata tgacggaaag aaaatcgaaa ccggcatcat gaagcggccg 740341 gctaaatcag ccgtcatgct gtatcgggag aattttgaag gagacggaca ggcggacctc 740401 gtcaaccacg gcggacctga taaggctgtc tgtgtctacc cggcggagca ttatccgttt 740461 tgggaagagt tcctctcaag accgctgtca aatgccgcat ttggagaaaa tctgacggtc 740521 gcgggcctga ctgaggagaa tgtttgcatc ggggatgtgt tcagacttga tgaagctgtt 740581 gttcaggtca gccagccgcg ccagccgtgt gtaaagctgg cgaaaaagtt tggtgtaaaa 740641 gaaatggtgc tgaaggtcca gcaaaccggc tatacagggt tttattttcg cgtgctggag 740701 gagggcaggg tgtctcccgg cgcgaacctt gaattgctgt ccagaggaga gaaaggcata 740761 tccgtccagt tcgcgaaccg catcaactac catgatgcaa aaaatctcac cgccattgaa 740821 cggattttaa gtgaggctgc actatcggaa agctggagag cgtcctttat gaaaaaaaag 740881 gacaggctgc tgccggttga atagaaaaaa gccgcgcata tcaacgtgcg cggctttgcc 740941 atatttaaga ttgttttttc tttgattcaa gcaggttggc aagaaaatag gttttatagc 741001 tttgaagctt tcttccttca tggtgcgtga tcccctgctt ttttagttct gccacatacc 741061 agcctttact gccgtaatgc atgtcagaaa actcctttcc ctatctgatt tcgaaacgat 741121 tggcattgta acatctataa aaagatgctg aaaagagatg cggggaaaac tgagcctttc 741181 gcactagatg tacgaatgtt cttctgaatg tatatgcgga gcaaaagccg aatatgattt 741241 aatggccggt tagtttgatc atgacaacgc caaatgtcat aatggcgaaa acaatgccga 741301 tatatgtgag catcccgttt tttttcttaa cgccgtaaac ggtcataatg atgccttcaa 741361 tgaaaaaaat gatgccgaaa ataataaacc acatgcagat aaaggctcct ttcacagaca 741421 taatagtagt gtagcatatc tgaaagagcc gggctgtgac aatatcaaga aagccgggcg 741481 catatcgccc ggctcatgtt ttattgttta tcaaccaatt tgaccagaag ctgtgccaaa 741541 tgttctttct catcttcgtc tgcaacgctc caaagctctt gcagcagcat ttcttcaccg 741601 ttttgcggct cttcatgctt tgcgaggtag tctcccagga tcgcagcgct ttttacaagc 741661 ttgccgtcat ccaatcccag ctttttgcct cggttgactt gttttttcag gtagccttta 741721 aattcctcaa agtcttttaa aatgtcttct tttattgtgc catgcatcgc gttcatttcg 741781 ttttcaattt ggattttttc ttgatctctg ttcattgcaa gacctcctcg tacagaataa 741841 tgatgcttta cctgcaattg gaggaggtta aacctgccgg aagcccggaa tgtgttttac 741901 agtttcgtca ggataatcgg ttcatctttt gtgatgacga tcgtgtgttc aacttgggca 741961 accatgcttt tatccggcgt cttgaacgtc cagccgtctc cagcttcaac aatcgtttct 742021 gctttcgttg aaataaacgg ttcaagcgcg atgactgtgc catttttgaa cagcgcatta 742081 tcaaacggat cataatagtt catgatgtgg ttcggcgctt catgcaggct tcggccgatt 742141 ccgtggccgg tcagggtttt gatgacggta aagccttgag agcgtgcttc atgataaacg 742201 gctcttccga tctggttttg gcgcttgccc gcttttgcct gctgaagccc cttttgaaaa 742261 gcgttttccg cgcattggca aagcttatga aggcgttctt ctccttcacc gagcacaaat 742321 gagatgcctg tgtcggaata gaagccgcca aattcagcgg agatgtcgat gttgacaagg 742381 tcccctgctt ttaaaatttt ggatgtgctt ggtatgccgt gagccacttc atcatttacg 742441 ctgatacatg tcacacctgg aaaatcgtat tccttctcag gagctgaaac ggcgccgtgc 742501 tcatcaagca cagcttttcc gataaggtca aggtcttttg tgctcatgcc gggctctgcc 742561 ttccgcttca tttcttcacg cgcaagcgcg acgattcttc cgattttttt caggccttct 742621 aattcttgat cgtttgttac aatcatctgt cattcccgct ttctttttaa ataatctaga 742681 ttaagcttac cacaactgtc ttaaaaatag gaaacacacg gacctgggaa aaaagaaata 742741 cccccgggaa aattggtata gatcactaga tatcttatat ggtatatttg aaaaaaaagg 742801 gtatgagggg gatgggtatg ctttcatttt tacaaaaact cgggaagtca tttatgctcc 742861 cgattgcggt tctgcctgcg gttggaatta tccttgcgct tggcagagag gatgtattta 742921 atatcccgtt tgtctatcag gcggggacgg cggtttttga tcatctgccg cttatttttg 742981 cgatcggtat tgccatcggc atttcaaaag acagcaatgg ggcagcgggt ttatcagggg 743041 cgatatcgta tctgatgctt gacgcggcaa caaagacaat tgataaaaca aataacatgg 743101 cggtgtttgg gggaattatt gccggtttaa ttgccggtta cacctataac cgcttcaagg 743161 ataccaagct gcctgaatat ctcgggttct tcagtggcag acggcttgtg ccgattttaa 743221 cagccattat tacgatcatt ttagcgggca tattcggagt ggtctggccg ccgattcaat 743281 cgtgtatcaa ctcgtttgga gagtggatgc tcgggctcgg cggcatcggg gcaggcatat 743341 tcggcctatt caacaggctg ttaattccgc ttggccttca ccatgtgctg aacaatattt 743401 tctggttcca attcggagaa tataacggag tgacagggga tttggcgcgc tttttcgcga 743461 aagatccgac tgcgggcaca tatatgaccg gatttttccc aatcatgatg ttcggtcttc 743521 cggcggcgtg tctggctatg gttgtgactg cgaagccgtc taaacggaaa gcgacggctg 743581 gaatgatgat tggatttgct ttaacggcgt ttatcacagg gattacggag ccgattgagt 743641 ttgcatttat gtttttatct ccgcttttat acgctgttca cgcggtctta accgggttat 743701 ctttatttat cgtcaactgg ctcggcatcc gctcaggctt ctctttttca gccggagcta 743761 tcgattatgt gctcagctat ggaatcgcgg aaaaaccgct gcttctgctt ttggtaggta 743821 tatgctatgc ggcagtatac tttatcgtgt tttatgtact gattaaggct ttgaatttaa 743881 aaacgcctgg acgggaagac gatgatgtgg atgaagtgct ggatgaaaat actgttcagg 743941 atgtaaatga aaacatcatg ctgaaagggc tcggcggaaa agaaaacctt caaaccattg 744001 atcattgcgc cacaaggctg cgactgactg tgaaggatac cgctttggtg gatgaagcac 744061 tgctaaagaa agcaggcgca aaaggggttg tcaaatcggg cgggcaatcg gttcaagtca 744121 ttattggccc gaatgtggaa tttgcagctg aggaattgag ggctgctgtc aaataaaaaa 744181 gcggagaggg caacctctcc gctttttctt atttatcttc gttatccttt gacgtttcgg 744241 aagaatcttc gtcatgtttt gtgtaatcat aatcagaagg attcaccttc ttaaaacctt 744301 tcggctcgta gaaccgcagc aggtctccgt ttatgatttt atcggacatt tcaagttcct 744361 tcttgacgag tgagtcttct gacttgtcga cttcggattc atcgagttct tttccggttt 744421 tcgtgtcgta atacttaccg gatattttcg tgtacttcgg tgaaataaag tctccgtttc 744481 ggaacggaat cacttcacgg tgttctttcg ataaaatatc agaaccggac atcagatagt 744541 ccttcgtatc cactccgagc agatgcagaa tggtaggagc cacatcaacg tctccggcat 744601 atttatgaac tttctcgccc ttcacgccgg cagcgtggat aaagagcggc acccgttgaa 744661 gctgggcgtt gtcgtaatca gtgatttcat ccttgccaag cactttcgcc atcgctttat 744721 tgtggttttc agagatgccg tagtggtctc cgtacatcac aataatcgat ttatcatata 744781 acccgtcttt tttcagatca ttgaagaatt gttcaatgga ctgatcaagg taatgggctg 744841 actggaaata gttatcgacg acagagtcac caaagtctcc agccgggaag tctgtatccc 744901 cctcatccat tccgaatggg aagtggttgg aaagggtaat gaacttcgta tagaacggct 744961 gcggcaggct ttccagcagc ggcattgatt ctttgaagaa cggtttgtct ttcatgccgt 745021 agtttttcgt gttttcttcg ttcatgtcat agtaagcaga atcaaagaat ttatcaatgc 745081 cttccgcctt gtacatttcg ttacggttcc agaacgtctg cgtgttcccg tggaaagtag 745141 cagatgtgta attcttagac ttcagaatcg ccggaacgga ttgcagcgtg ttttgcgctt 745201 tgtttacgaa aactgaacct tgagccagcg ggtacagaga gttttccatc ataaattcag 745261 catcagatgt tttaccttgt cccgtttggt ggaaaaagtt atcaaagtag aacgtttcgt 745321 tatcatgtgc cagtttattt aagaatggtg tcacttcttt gccgtcaatt ttatagtcga 745381 tgataaatga ctgcaaagat tcaagtgaaa cgtaaatgac gttttttcct tccgctttgc 745441 cgaaatacac gttattcggc acatcgtaat tggctttcat gtagttttct acttccgtta 745501 cgtcgctgga atcggcaagc gcgcgctggc tgttggactt gatattctgt acagcgtcat 745561 aaatcgtgaa attgtatgtt cccaagtatt tcacaagata gttccggtcg aatgatcttg 745621 tcagcaattc aggacggtct gattccgcaa ctgccaggtt gatcaagaac acaagaattg 745681 aagacgcaaa aataattcgg aacgattttt tgcttgacgt ttcggcaggc ttgtttactt 745741 tgatcgccaa gatgatcagg atgatcgtat cgataaagta aaaggcgtca gtcggtctca 745801 tcagcgaaaa tgcgctgtca ccgagttggc cgccgtttgt tttagcctgc ataatgaccg 745861 gaattgtaat aaaatcattg aaaaatctgt agtacacaat gttggcgtac agtaaaaaag 745921 acattaaaaa atgaatcact ataatggctg tctgctgtaa ttttttcttg aacaagagtc 745981 caaagccaag aaagaacaag cttgagctaa gaggattcac aaaaagcaat attttttgta 746041 tcgtgttgtc tattcctaag ttgaaattca ggacataacc gacatacgtt ttgatccata 746101 acaggacgac cgcaattaag aagaaggcca gtcctctttc ttttataaat gttttcattg 746161 ttacactcct tttttccgat ccagttcgag cgaaacgata gaaaaaacga acgtatccaa 746221 tataacacga atcagcagat tagaaaagtg aaaatcgtat gagggagaaa gtggcgaaaa 746281 acgccgtcga atcaacgttt cgctttgata ttaccaaatg taaaacaagg tatctttcta 746341 gaaataaagg aataaaatgg tacattgaga attgtatgat aaaatataag gtatagataa 746401 aaagaggtga aatgatggat ttttcccata ttgtgtctga agataaaatt aagcgcgcca 746461 tcaaagacgg ggactttcaa aacctcccgg gaatggggaa gccgctgccg aaggatgacg 746521 cggcacactt gccggaatcg ctgcgcatgg gctatcgtat tttgaaaaac gcgggaatgg 746581 cagaggacga gggcgcgctc aaaaaagagc ttatgaccat cgaccattta atcgaaaagt 746641 gctatgacga aaaagaacgc gagcaattaa tcagaaaaaa atctgaaaag caattgctgc 746701 ttgataagct tgtcgacaaa aaaggcatgt tttcaaagcc agcatccgct ttttataaga 746761 ataaagtata tgaccggctt ggacgaaaca gaccttcttc cagctgattt gtcttgtctg 746821 caggatggcg attgataaaa gccatccttt ttatgttcca agttctatgt caaaaggttt 746881 atgtttttcc atctatggga aatgattcat aaacgaaaaa agggtgatgg gatggaacga 746941 ctattagtat ggatagagca tatatctgat tggctgtggg gtccgccgct aatcatcctg 747001 ctgacgggga cgggcttgta tttcactatt ttgctgaaag gttttcaatt tcgctatcct 747061 ttatacattt tcaaacagac aatcggcagt gtaggaaaaa agccgaaggg agaaggcaca 747121 gtcacaccgc ttcaggcatt gacctcagcc ctcagttcaa cgatcggtgc agcgaacatt 747181 gtcggtgtgc ccgccgctat tatgtttggg ggaccaggag cggttttttg gatgtggctt 747241 attgccttat ttgccatggc gattaagttt tctgaaagtg ttcttgctgt tcattacaga 747301 gaaaaaaatg agcagggtga atacgtcggg ggaccgatgt attacataac aaaagggctg 747361 cgcatgaaat ggctcggcgt attcttctct gttgcgctga ttgtggagct gattcccagc 747421 attatggttc agggaaattc ggtttcagtc tcgcttgccg agacgttttc tttcaataaa 747481 atatacgcag gaatcggaat tgcatttttg attgggttag tggtgatagg aggggtaaag 747541 cggatcggaa aagtaacaga gtttgtcgtg cctcttatgg caggggcata cgcaggtgcc 747601 ggtctcctga ttgttctcat gaatctatca tcagtgccgg cgtttttctc tctcgttttt 747661 tcaaatgcgt ttacctcttc ttcagcagtt ggagggttcg caggtgctgc gttggcggaa 747721 accgttcgct ggggatttgc ccgcgggctg tattctaatg aagccgggat gggaacagcc 747781 ccgattgcac atgcggcagc aatgactgat catcctgtgc ggcaagggtt ttggtctgtg 747841 atcggcattg tcattgacac cttaatcatc tgtacgacta ccgcttttat cgtccttgca 747901 tccggtgtat ggacagggaa gaacgcctca aatgacccgg cagcactgac aacggccgca 747961 tttcagcact atttcggttc tggaggagga tacttcgttt cggtttccct ggtcttcttt 748021 gtcgtatcaa ccattatggt tgtcattttt tacggcgtaa agcaagctga atttctgttc 748081 gggcggctgg caggacatgt gattaaattc gtttatttag cggctattat cataggtgcc 748141 gcaggcggag caaaagccat ttggggcgta ttggacttag cattggtttt tattgttgtc 748201 ccgaatgtga ttgcgctctt gttattgagc agaaaggtaa aagcgctgta caccgaattc 748261 tttacatctg aacagtacta cctgaaagat ataagaaaaa cgaaacaaaa gcctgtttat 748321 ccaacaaaag aagctaaaaa ttcctagtgt tttgcttttg cgccgaacaa tgctttgctt 748381 tttatgatca aataaatgag taaaggcagc aaaagagaaa tcactacatt aatgattggt 748441 ttgattctgt taaagtcgat tagctgattt gtatttaaaa aaaaccaaaa gccgcatacg 748501 actgagaaca tgccggttgg tgtatacatg gctttcgggt cgatttttga gtgtaaaaac 748561 gaaaggccgt ataccacgat atatagggaa cctgctatct tcaccataat gaccggaatc 748621 caaaaagccg cgatgatcag gtctgagcga tccagaaaat ccgtaatgcg gatctgcctg 748681 atgaccatat aagcaggatc aaagaaagta gatgtcaggt tgggaccaaa gacagaaatt 748741 gaagaaaata acatcacggc cagcaataaa gcgcccagca gtatcgcgaa aatggtgtat 748801 tttagcggga cgctccggtt tgagaagaga agcggaagga taatcaattc ccccattgtc 748861 ccaaacgcgt aatagcctga ttgaaggtat gggattagac cttcaaaaac aggtgtcaag 748921 ttttgaagct caatttgtgt ggccagcgta aatggaagga acaagaccag gatgccgaat 748981 ggaaatagga atatctgcgc cattctggtc aatgtttctt ttccctctct ggcaatacag 749041 atcgccacaa agataataac accgccaaga acagccattg gtgttctcgg gagaaataaa 749101 atgttaatca aattgatgaa aaaacgtata tcatgagcat tgattaacag gaaatacaaa 749161 gaaaacagta aaatgataat ccggcctgcg attggtgagg aatcgctcag cagctcatag 749221 atatttttat cctgatgctt tttcatcagc ctatgcatga gccagagtgc cggaatcacg 749281 atgacaacgc cgaggatgta gctgtgccag gcattttgtt ttgctgattc gatcatgaga 749341 atcggagcat gctttaatcc gactgctaac gtatacagag ctccgaaaaa taatccttgg 749401 tatgcagagg tcttgtccat aaagcacatc ctttctgtca tgttcaaaac ggaatatatt 749461 taaacaggtg ccccagccgc ggaagcaggg gattcactct catataaatc catagaaaag 749521 cacttcctgc aattagcagg ctgaaggccc attttgttag attgttagcg gaacgaaaat 749581 tcttccattc atatgcgtat atggcaatgc acacaatcaa tgtctgtacg atatagctga 749641 tcatgctgac gcacctccat taatggctga tcgttttgta taggacaccg ccctgctcaa 749701 tcgtcacaat tgggacgacg tgaacctcca tatccttata tacctcttcc cattcctttt 749761 tcagcagatt cttcgtggtt gccgtgcttc tgatggtcct gtcttgaaag ccggccgggt 749821 ccgcctttag cttttgcaaa cgatgaacgg tgctgatcac gtccttcttt atggttctgt 749881 ttaatgcttt ttgaatgatg taatactggt cattttctct cgtctcatag gttgattggt 749941 tttccataat aattcctttg gctctgatct cgattgtcat tgacagcttt ccgttttttt 750001 cagcggcatg aaaggatgca ttggactttt gaagctgaat ggatgcttgc cccatttgat 750061 tcggcaggtc tactatgaat tctggctggc gggcttgatt cagcaacatc agggctgctg 750121 tcatgtgttc atctttgaaa atatccatca atctgtcctt tttaaagatc gcaagcccgt 750181 caattttcaa attagatttg cctttccctc caggttttgt tttagatgca gagatgaccg 750241 gtgcatacgg atcactgcct atttctacta gatcagacat gaatctgctt aagaaaacgg 750301 ggcggctcgt tgcgataatg gccagctccc gaatcatttc cgccggaaac tgttcaagct 750361 gaacatcggt atttaaaatg tcccgcgctt ctccccggct gactaaaatg agcgccgtta 750421 atctgttctg cggatttcgc gttaaaatat caaagactgg ggcaacgccg tctctcgcca 750481 tatcctctcc aataatgact gtacgtctgt gggacgtatt gattgtccgt gacaaggagg 750541 tttgcagctt gttgttcgct tctctgatcg tagtgccgga agctgaatca acataccatg 750601 tttttgaacc ggcagttccg ccgccgcccc ctgtttgtcc gcctaattgg ccgaccaagg 750661 gaatctgcat ggccactcga tactgatctt ttttcttatc aatggctgag ctgacaacaa 750721 atgcaatgtc attgatttct gtccggtccc agcaccccgt tagaaggata caaatgagaa 750781 gcggcaaaac acacttatat attgttttct tcatcttttg ggtcctctct tttcgctccc 750841 ttctgtccgt tgccgcgcga atacgtgccc ggccttctgg tcatcgtcca ccaaggcgcc 750901 ctgacaaaaa tatcttttac ttcatctcgt ttaaacggag aaatcccgga taaataagga 750961 atgccgaaag attgcagctt gcataaatga agcactaaga taatcgtgcc gagcataatg 751021 ccgaatatcc caaaaatact cgccaaaaac ataagcggga aacgaagcat cctgatggag 751081 atagctaagt taaaccgcgg aattgtaaat gacgcgatcc ctgttaacga tacgatgatc 751141 accatggggg cagacacaat tcccgcttca acagcggctg tcccaatgac tagggccccg 751201 agaatactga cggtctggcc gatggttttc ggcaggcgca ctcccgcctc acggagagcc 751261 tcaaaagaaa tttccataat caatgcttct atgatggcgg ggaaaggaat cggttcacgc 751321 gcagaggcca cactgaacat taagtttgtc ggcattaagt cctggtggta tgtaataacg 751381 gcaacataaa tagccggcaa atataaagca acgaataaaa acatatagcg aagccagcgg 751441 attaagttag acatcaaata acgctcatag taatcttcac tggcctgcat aagctgccaa 751501 aacgtaatcg ggcctgttaa gacaaagggc gtattatctg tgaaaatggc aaatcggcct 751561 tcgagaagct gggcggcgac ggtgtccggc ctttctgtgt attgcagctg ggggaatggc 751621 gagtacgtgt cgtcttcgat aaattcttca atatatccgc tttctaagac agcatcaatc 751681 tttatctttt tgattctttt ttttgctttg tcaataacct ttggatcggc aagcccgtca 751741 atataggcca agacaacatc ggttttggtt ttcgtgccga ttttaaaaga gatcatttta 751801 agctgaaacg ttttgacgcg aaagcgcaca agagcggtat tgaccctgag gctttcagtg 751861 aagccctctc ttgaccctct gatggtcgat tctgttatcg gctcttcaat gcttcttctt 751921 tgtccgcctt ttatatttaa gatcaggcct tttgagtgcc cgtcggcaaa taaaaccgcg 751981 ttcccctcaa tgatggatgc agccactttg ctcatactcg tttctaatgc aacacttgaa 752041 attgatagag tattttgcag cgcctcttca tgttcatcta tttgatccgt caaatgcatt 752101 aagaaagggc ggagggcgtg atcctgaata tgttcagatt ttacaattcc ttcgatataa 752161 acaataaatc cgcacagccc gtttccaaag tcaaattgtc taaatacgat gtctgagcag 752221 ccttctgtta ataaggtcag attttcgagg ttttccttca aattgggaga gatcggtctg 752281 tcctgattgt cttcaagctc tttgatgagc tgaagcgctt tgtcgcgttt attcatagag 752341 gctcaccctg ctttttaatg tcatattcaa taagtgcttg tgacttttag ggtaaccttg 752401 tctgtttcat atattccaga ctaggatgaa agcgctataa aaaagtgttg actacctgta 752461 tatacaggaa tacaatatga ttataagttg tatatacaag ttataaaaac ggatacggag 752521 gggttggcat gggggaactg aacaaatcgg cacgtcagat tgtcgaagca gtcggcggtg 752581 ctgaaaatat tgcagcggca actcattgtg ttacacgttt gcgttttgct ttaatagatg 752641 aaagcaaggt tgaccaagag atgcttgatc aaattgatgt ggtaaaggga tcattctcga 752701 caaacggaca gtttcaggtc gtaatcggcc agggaactgt caataaagta tatgctgaac 752761 tggttaagga aacggggatt ggcgagtcaa caaaggatga agtgaagaag gcctcagaaa 752821 aaaatatgaa tcctttgcag cgtgctgtga aaacgcttgc agatattttt attccaatat 752881 tgcctgcgat tgtcacggcg ggtcttttaa tggggatcaa taacatttta acggcggaag 752941 gcattttctt cagcacaaaa tcgattgtgc aggtttatcc gcagtgggcg gatcttgcta 753001 atatgattaa cctgattgca ggcacggcct ttacgttttt gcctgcgtta atcggatggt 753061 ctgccgtcaa gcggttcggc ggcaatccgc ttctcggcat tgtgctcggg gttatgctcg 753121 tgcatcctga tttgctgaat gcgtggggat atggcgcggc agaacaaagc ggagagatcc 753181 cggtatggaa tctattcggc ctagaggtgc agaaagtcgg ctatcagggc caggtgctcc 753241 caattttgct tgcttcttat atgctggcga agattgaggt atttttaaca aaacgcacac 753301 ctgagggcat acagctgctc gttgtcgcac caattacgct tctcttaaca ggatttgcct 753361 cttttatcat tatcggcccg attacatttg cgatcggtaa tgtactgact tcagggctta 753421 tctcggtgtt tggttctttt gccgcactgg gcggtctgtt atatggcggt ttctactcag 753481 cgctcgtgat taccggtatg catcacacgt ttcttgcagt cgacctgcag ctcatcggtt 753541 caaagctcgg cggcaccttt ttatggccga tgctggcgct ttctaatatc gcacaaggtt 753601 cggcggctct ggccatgatg tttatcgtga aggatgagaa acaaaaaggc ctctccctca 753661 catcagggat ttctgcttat cttggcatta cagagcctgc catctttggg gtgaatctgc 753721 gatacagatt cccgtttatc attgcaatgg tcagctctgg cctggccgga atgtatattt 753781 cttctcaagg tgtgctggca agctccgtcg gtgtcggcgg cgtgccgggg attttctcaa 753841 tcatgagcca gtactggggc gcgtttgcaa tcgggatggc tattgtattg atcgtgccgt 753901 ttgccggaac atacgcgtat gcgagattca aacataaata acaagtgggg agcgggacgt 753961 gttgaacgtt cccttttccc gttttcaatt taaatatggt ggtggaaaca gatgaaaaca 754021 gaacaaacgc catggtggaa aaaagctgtg gtttatcaaa tttatccgaa aagctttaac 754081 gatacgacag gaaatggtgt tggcgatctg aacggcatta ttgaaaagct ggattactta 754141 aaaacgctac aggtggatgt gctttggctg acgccgattt atgattctcc ccagcatgat 754201 aatgggtacg atattcgtga ttattactcg atttatcctg aatacggaac gatggaggat 754261 tttgagcggc tagtgtccga agcacataaa agagacctga aagtcgtcat ggatcttgtt 754321 gtcaatcata cgtcaacaga gcacaaatgg tttcgcgagg cgatctcttc aatagacagc 754381 ccgtaccgtg atttttatat atggaaaaaa ccgcaggaaa acggttctgt tccgacgaac 754441 tgggaatcga aattcggcgg ctcggcatgg gagcttgacg aagcatcggg ccaatactat 754501 ttgcatctgt ttgatgtgac gcaggctgat ttgaattggg aaaatgaaga ggtcagaaag 754561 catgtctatg acatgatgca tttttggttt gaaaagggaa tagacggctt taggcttgat 754621 gtcatcaacc tgatttctaa agatcagcgc tttccgaatg cggaggaagg cgacggccgc 754681 tctttttaca ctgacgggcc gcgggtgcac gaatttctgc atgaaatgaa cgaaaaggtg 754741 ttttcacatt acgacagcat gacggtcggt gagatgtctt caacaaccgt agaccactgc 754801 atccggtata cgaatcctga caataaagaa cttgatatga cattcagctt ccatcatctc 754861 aaggttgact atcctaacgg cgaaaaatgg gccttggcgc cgtttgattt tttgaagctg 754921 aaggagatcc tatctgactg gcaaacgggg atgcacgcag gagggggatg gaacgctctg 754981 ttctggtgca atcatgatca gccgcgcgtc gtatcaagat atggagatga tggcgcatat 755041 agggtgaaat cggcgaaaat gcttgctacg gccattcata tgatgcaggg cacgccttat 755101 atttatcagg gcgaggagct ggggatgacg aatccgaagt tcactgacat aagctcctat 755161 cgggatgtcg aatcgctgaa catgtatcac gcctttaagg aaaaaggaat ggctgatcaa 755221 gatattacag ccattttaca ggcgaaatcc cgtgacaatt ccagaacccc cgttcagtgg 755281 gatgctacgg aaaatggtgg ttttacaacg ggcacaccat ggataccggt tgcaggaaat 755341 taccgggaaa tcaatgctga agcggcgctg agggatcaga attcggtgtt ttaccattat 755401 caaaaattga ttcagattcg caaaatgtat gacattgtga cagagggtac gtatgagata 755461 attgcaaagg atgacccgaa catttttgcg tatctcagac acggcagcaa tgaaaagctg 755521 ctcgtgatca ataattttta cgggacagag gcggccttta cactgccgga ctctttagcg 755581 cctgacgaat ggaaggcaga ggtgctgttg acgaacgatg aagcaaggga agggcttcag 755641 aacatgacgc ttcgcccata tgagtccatt gtttatcgtt taacgaaacc gtgttaaact 755701 aagctgggtg gtccataatg aaggtgaata aattcatcac aatttataaa gacatcgcac 755761 agcaaattga aggcggccga tggaaagcgg aggagattct tccgtctgaa catgagttga 755821 ccgcacagta cggtacatca agagaaacgg tccgaaaggc gcttcatatg ctcgcgcaaa 755881 acggttatat ccagaaaatc aggggaaaag gctccgtcgt gctcaatcgt gaaaaaatgc 755941 agtttcccgt ttcgggcctt gtcagcttca aggagctcgc gcaaacgctt ggcaaagaaa 756001 cgaaaacaac tgtacacaaa ttcgggctgg agcctccgtc agagctgatc caaaaacagc 756061 tccgggccaa tctggatgac gacatctggg aagtcatcag gtctagaaag attgacgggg 756121 aacatgtgat tttggacaag gattactttt tcagaaagca tgtccctcac ctgacgaaag 756181 aaatttgtga aaactccata tatgaatata tagaaggaga gctcggtctt tcgatcagtt 756241 acgcccaaaa agaaattgta gccgagccgt gtacggacga ggacagagag ctgctcgatt 756301 tacgcggcta tgaccatatg gtcgtggtga gaaactacgt ctttttggag gataccagtt 756361 tgtttcaata tacggaaagc agacaccgtc tcgacaaatt ccgatttgtt gattttgcgc 756421 ggcgggggaa atgagagagg cgcctgcctg cggcagcgcg cttttttgtt tggtatcaaa 756481 attgatacta tccaacaaaa atgtgcgtac ttttactttt tatcataatg gctacaatag 756541 agatgagagt aatctaaagg agaggtgttt tacatggcag atctaaagac acaaattctg 756601 gatgcataca atttcaggca tgcgactaag gaatttgacc cgaataaaaa agtgtcagac 756661 agcgattttg aatttatttt agaaacagga agactgtctc cgagctcact cggccttgag 756721 ccttggaaat ttgtcgtcgt ccaaaatccg gaattccgcg agaagcttcg tgaatacaca 756781 tggggcgcgc aaaagcagct gccgaccgca agccatttcg tcctgattct tgcgcgtaca 756841 gcgaaggata tcaaatataa tgcggactac atcaaacgtc atttaaaaga agtaaaacaa 756901 atgcctcaag acgtgtacga aggctattta agcaaaacag aagaattcca gaaaaacgat 756961 ttgcatttgc ttgaaagtga cagaacattg tttgactggg catcaaaaca aacctatatc 757021 gcgcttggca acatgatgac tgccgctgcg caaatcggtg ttgattcctg cccgatcgaa 757081 ggcttccagt acgatcacat tcaccgtatt cttgaagaag aaggccttct ggaaaacgga 757141 agcttcgata tttctgtgat ggtggcattc ggctaccgag tgagagaccc tcgtccgaaa 757201 acaagatctg ctgttgaaga tgttgtgaag tgggtttaaa agaagaaagc tgctcgcata 757261 gcgagcagct cttttttatg cctgattcgc tctattctgt tttctcctct gatgtaagta 757321 cattgccgtt ccgagtgcgc tgatcagaaa tccggccaac aggatcgagt acatggatgt 757381 ggctgtgtcc ggaagcaggc cgccagccgg accgtctgtt cctgatccgc ccgaaccgtt 757441 tccaccagag ccgttagtcg gttgagtgcc gggaggcgta tcatttcctc cgtttccgtc 757501 agttggctgt tttccgcctg gtttgtcgga gcctccgcca tgattgccgt catcaccgcc 757561 tgtcggttga tctgacggga atgccggcgg tttgttgttt gaaccggaat ttaagatcgt 757621 gtattcgctg aagtggtttg tatatcctgt caccatatca tcatcgactg atccgtgacc 757681 tgtctttgtg aaagctttct tttttctatc gacgtgataa atggcagggt tatgggcttc 757741 ttcaatatca aacatgcgaa gcgaaagctg tacgggctcc ttgaatgatt ttatttcttt 757801 tcctttttgc ttcactgtaa agtcatatac atctgacagt gacacatcca attctcccgt 757861 agacttgatt ccgattgcag tgtctgcggt tttaaggttc gccattggca tcttcatgct 757921 gtaccagtag ttgaacatcg tcaatgaagg atctgactct ctttctttca aaagtttgac 757981 ctgatctttt ttcactttaa gattgatagg cttctcttga gatccttcat gtattccata 758041 atagacaaat ggcgtgttgg catttttagc ataaatcgca aatttgtctt catcaagtgt 758101 ccagctgccg tccttctgct ttgtcggcag gaatacttct ttgattcgtc cttcaacttt 758161 aggagagacc ttgtttccta gttttttcag ctgttcggtg aaaatctcat aatcaacgta 758221 gccaaggtct tcaccatggg aggcttctgt aaagacagaa tatccgtctc ctccggcacc 758281 gacaaaatta tttgttgcca cgcggtaggt atcatccgta tttatagcaa ctttgtctcc 758341 gttaggcgat tcaattttca cttctaacac acggtgtcca ggtttgttgt ttaatgtaaa 758401 ggtatattcg attccggcca cctgagggaa agcgccgccg ccattttcca cattgcttag 758461 gccttgttca agggcttctt taatttgttt tccggttaaa tcggccacgt aaagcgtatt 758521 gccgaacggc atcacgttga gcacctcgcc gagtgtgata tcacctttgt caatgcctgc 758581 tctgatgccg ccgccatttg ttatcgctat tctggcgccg gctgcttctt tcgcttttgc 758641 cagcataccg tccgcgatga agtttccgag attcgtttct ttcgtgcgca catgctcacg 758701 ctggccgtca agcgccacat ccgtgtagcc gactttttca tttttcacgt cctctaattc 758761 atttttgaac tgatcgagct cttgttttgc ttctgggttt tcttctgtat gttcatcaat 758821 tggcagcacg ctcagatttg atttatctgt ttgcacaacg cctttttcat caaacgcgac 758881 atcaacgcgc cccaagaatt ggccgtattc ttttgcctgc gccacgatcg tcggttcttc 758941 gttgttcacg acctccattt tgtctacgag ggtgtgagtg tgtccgccga tgatcaaatc 759001 aatgcctttt acttttttgg ctagctcaag atcccggtta tgtccgatgt gggttaaagc 759061 aataatttta tttacctttt cttcttcttg aatcgctttg acggtgtttt gtgctgtttc 759121 aaaggcatca ttgaatacga tgcttttgcc cgggcttgat gtggtggctg tatcttctgt 759181 tgtcaggccg aatacggcga ctttctcccc gtcaacgtct aacagaatgt aagggtgaat 759241 gccggcctct ttcttttcac ctgccgtaaa ggtttgcggc tttttgacaa atgatttcag 759301 cttgggctca tttgacacat ctacgtttgc actgacaatc ggaaattccg gcgcttcaaa 759361 gtgatagcgg ttcgccggat caacggttgc gctgtttccg cttagaaaat cagaaagcac 759421 cgtcgggcct ttgtcaaatt catggtttcc gaaggtcatg gcgtcatagc ccatcatgtt 759481 catcattttc agatcggcca aaccgttcca tttagtaaaa tacagatcgc cggaaaacac 759541 atctcccgca tcaaggagaa tattgtgatt tgtttcgctg cgtacttcgt tgattttcgt 759601 cattcgtctc gctgcatcat cgagatgggc gtgcgtatca ttggtgtgca tgacggtcag 759661 atcccacagt ccgtctttag gaggatctgg atttgaatca tcatcgaatt gcagcttata 759721 cacaccatag ccttcattcg cagacttgcc tacataagcg acatcgtctg ctttatcggc 759781 aaatggcttg gccaaaagcg aggattcaaa cgtcagattc gtgccggaaa caggcgcgat 759841 tgaccagttg ttgtctgctt ttggattgac tgttttttgt tcaataatgt aatccatcag 759901 cacctgccta ttttcaactg cagagccgtg gacaatttta tcgctcgtca gatgagggaa 759961 cccgccgcct ccggacgcac gatagttatt ggtgactacg agaaattcct ggcttgggct 760021 gatcggcttg ccttcatagg aaagattgat gatacgggat gaatccgcat tgatcacttt 760081 tccgttctca ttgtatttag ccggttttgt cacatcgacc tgatatgtga caccgtcaat 760141 cacgtcaaaa ttataggagc ggaaattctc gttcagcaag gcctggtcgc cgcctttagc 760201 tggatcaatt tgattgaatt ggcctgctga catctccagc cagtccttga cctcgctgcc 760261 tgtcagcttg acgatttgaa cagtattatc gtaaagatac aagtcaccga catttttaat 760321 cgcaagatct ccggctggaa tgtttgtata gtaattggct ccgtttctgc cgcctgcttt 760381 aaacggcgct ccagcggata aaatcggcag gttcttgtac tcggtatcct tcatttcttt 760441 ttcagcgtac cacttttgcg cgtcagtcac gatctgaatg gaaggatcat ctttgacctg 760501 tgcaaagaag ctgttaatat ctgcttcggt tttgccgact ggctttcgga catactccag 760561 tgtgttttgg tgtgtttgct gaatggtgtt tgtaacggtt tcgtttcttg atgtgacgtt 760621 gccagcaata gattcaatac ttcctttgga atctgctacc ttccatgagc cgtccgcctt 760681 ttcaagcttg aggtcaatca cgcctaaata tttgccccag ctgcttggca tgacgacagg 760741 aatgccgtta attgttccct tttccacatt gaactgagca acacccgcat actcggcgga 760801 aggaaagagt ccgtgctgat ggcccgagat aatcgcgtca atgcctttcg ttttggtggc 760861 aaggtcaaac acggcgtttt ctgcgcctga tgattgcgcc tgcttttcaa tgccggtgtg 760921 ggcgagggca ataatgacat ctgcgccttc cgccttcatt ttcgggatcg tttcattggc 760981 ggattctacg atatcctgca cctgaacttg cccctcgaga ttctttttgt cccatgtcat 761041 gatttgcggc gggacaaagc ctatgtagcc gacttttact ttctgctcat taccgttttc 761101 atcaatgagg gttttttcat taatcacata cggcgtataa cggttttcgc cgctagttgt 761161 tttgacgttg gcatttacaa tcgggaaatc ggctcctttg attgtgccgt cgagaaagtc 761221 gagcccgtag ttgaattcat gattgccaag cgttccggcg tcgtatttca gcgcattcat 761281 gacgctgata atcggatggg ttttcgtgcc ggagataatg tcgtcttttt gatatttcac 761341 cgcgtattca cccagcggat tcccttgaat caagtcgccg ttatccacaa gcagggtgtt 761401 agggttttgc tcgcggtgct tttggatcaa ttgcgctgtt ctcgccagac cgaaatccgc 761461 cgtttctttg tcgctgtagt aatcgtaatc catcatgttg gcatgaatat cagtcgtagc 761521 caaaatactc agatgcacct gaggagccgc gctttcttct gcatgaatgg gtggtgttgg 761581 gaggattagg ctaagtatca taattggggg caaaagaata cggagaatgt tttcgacgtg 761641 tgttcgtctt ttctgtattc tcaccagttc tccacctttc aacgaaattt gtgttacagc 761701 tcctattgta agaatatttt gtaactattt gtaggtgttt ctttatgatt attgtaaaag 761761 ggagaaaaat gagtattatg tagcagtatc aaacgacaaa tactgggcat ttatgcttat 761821 cgtttgtcac aatcgcggaa tgtttatttt agtgtggctg gggtagagtg ttttatgtag 761881 acatataaag cgggaggtta tgaatcatgg ggaaaaaaat tgcagttgtt ttaacatatt 761941 attttgagga cagcgagtac actgagcctg cgaaagcctt taaagaagcg ggacatgaac 762001 tgactgtcat cgaaaaagaa aaaggaaaaa cagtaaaagg caagcaggga acagcggaag 762061 tgacggttga cgcgtccatt gacgacgtaa attcttcaga ctttgatgcg cttttgattc 762121 ctggaggatt ttcaccagac cagcttcgcg ctgacgatcg tttcgtccaa tttacaaaag 762181 cgtttatgac tgacaaaaag ccggtatttg ccatttgcca cggcccgcag cttttaatca 762241 atgcgaaagc gctcgacggc cgaaaagcga cgggctatac gtccattcgt gttgacatgg 762301 aaaacgccgg tgccgacgtt gtggacaagg aagtggttgt ttgccaggat caattggtca 762361 ctagccgcac accggacgat ataccggcat ttaaccgcga gtcattggca ttgcttgaga 762421 aataagaaaa aacggacgct cttgggcgtc cgtttttttg ttgcttaggc ttgagcacct 762481 gtcagtttct tgtacctgta atacaagaaa gcagctgcag ccgttccgat gaccgcaatg 762541 ccgaagtcga atatgaaaat atgggcgatg ccccccgctt ttgcgataag ccctgttgca 762601 atcggcagca gaatcgatgc aagacttgaa gcagtcgcta caattccggt aacggttcct 762661 tttcgcttcc agaaaagctc tgtcattaac gtaatggtaa tttgaaacac acccgcagtt 762721 gaaaagccta agaaaaaggc agtgatgtcc agcacaactg ggatatgaac ggtcagcatg 762781 actgcgagcg tacataaagt aataatagga tataagagcg ttatgaagac aggtttgacc 762841 catctattca gcaaaacggc taataataaa acagatgcca gagatcctat actataatag 762901 ctcagcaatt gtacagatgc tgattcagct aaaccggctg ccttttgcgc gtagctcggg 762961 agccagattt gagaaaccgt aaataaagcc gtggatgtaa aaccgatgat aatcagtgcg 763021 gtgccttcct tctgaaaaac gggttcagac aagaaaacgg gagattcctg ttggccgcta 763081 ttagttggtt tcttatgttt tttaggaaac gaaagcgttg ataaataaat aatattcagg 763141 agatagaccg ctgccggcag ataaaaagca aatccgtaaa acatgctgtg gtctgctaaa 763201 aatgtgatca aaagcggcaa aagtgcggcc cccacagaca taaaggcttt aaccaagaca 763261 tttgccgaac cggaagcaga cggaaagagc tcggttaggg ccggatatgt tccggcatcc 763321 atggctgaat tagcgactcc ggctaataaa gcgaacacaa acgccagctc atagctcggt 763381 gataaaggaa taccgactaa aaagacggcc ataattcccg cagaagcgac aacaagcggc 763441 tttctgccga ttttatctga tagaacgccg gaaatgccgt atgtcagcag tttgccaaac 763501 ccgatagcgg caatgacata actgatgccg gtcggatcgg tattccactg ttttgttaat 763561 gaagacatat tggatgcgag aatgatgttg accatcccca gaaagaagta gttgatatac 763621 attccggatg ctgttttgat agatgtcgtt tgcatgcttg tactccttca aatcttattc 763681 gaacactttg ctgttttggt ttggggaaat gataaaaaag actcgccgag tttccggcca 763741 gtctccatta tttacgaagc gaggctaatt cttgagcaat cgcctgcatt tcacttgggc 763801 tgaatgattc ttttttcatc accattctgt gaaggtacgt gaggtcttca atcttctcat 763861 cactgaaatc ctccgctttg attacgccga cgttcagcat gttcagcttt tgggaaatct 763921 cttcaatcat ttgagttaat gtttctgtat ttgggctgga caaagggttc catcctttct 763981 atgcgcaata taggtatgtt ttattctaac agaattccat cagaaaaaaa ccctattcta 764041 aaagcaggct gttcattcca aaaaagtgaa gacatcagtt gaaaagaaaa tgaacatcct 764101 actaagatat tcatgaaggt ttctttttag agaaataggg gcaaagaata gggaggttgc 764161 acatcatgat aagcgtgtta tttgtttgtt taggtaacat ttgccggtct ccgatggcgg 764221 aagcgatttt tagggacctg gcagccaaaa aaggattaga ggggaaaatc aaggcggact 764281 cagccggtat tggcggctgg cacatcggca accccccgca tgagggaacg caggagatat 764341 tgcgcagaga aggaatcagc tttgatggca tgctggcgcg tcaagtcagc gaacaggatc 764401 tggacgattt tgattacatc attgcaatgg atgcagaaaa tatcggaagt ctcagaagca 764461 tggcgggttt taaaaacacc tcgcatatca aaaggctctt ggactatgtt gaagattcag 764521 atctggctga cgtacccgat ccttactaca cagggaactt tgaagaggtc tgccaattaa 764581 tcaaaacggg ctgtgagcag ttgcttgcat ccattcaaaa agaaaaacaa ttgtgagtga 764641 aaggagaatt tgcatgaaca acgaacgttt aatgctgaaa gggatatttc tcggagctgc 764701 ggcaggcgcg gcgttatcac tgctccataa gccgacaaga caggcgtgcg ggatgagatg 764761 gctgacatgc aagcataaac tttcactgta caaaagcaac ccagagctgt taaaaaacac 764821 tgtcatcaca aaagtggatg aggccaaaaa gctcgcccga acgctttcaa aggaagtcga 764881 ctttgtgaac cagcaggtga aagagctgaa gaaaacaacg ccgcaagtga tggaactcgt 764941 gcaagaaacg aaagagcatt tttcaaaaaa atgatcaaac atgcgaggtg agacgacatg 765001 agttttttga aagagctttt cagcagatac acccttcatg aaggacaaag taaatcagcg 765061 gagctggcgt atttttttct attgtcactg tttccgtttt tgatttttat gctgacgctc 765121 accgcgtatc ttccgctttc taccgatgat gttttaggag tcatagaaca atatgctccc 765181 gccagtgcga tgtcactcgt tgaatccatt acccatcaaa ccttaaataa tcgaaatggc 765241 ggtttgctgt cattcgggat tatcgccgca ttatggtctg cgtctaatgg aatgaatgcg 765301 atcgtccggt cgctgaacca cgcgtatgat gtggaagaaa accgctcttt tatcattgtt 765361 cgtctaacct cgattttttt gacgattgcc atggtattta cgattttagt ggctttgctt 765421 ctgccggtat ttggccggga gattggaagg ctcgcttctg actttgtcgg cgcgtcggat 765481 ctgtttttat ccgtctgggc cgccattcgc tggggtgtca gcccgcttgt gcttttgatt 765541 gttttttccg cgctgtatgt gattgcgccg aacaaaaagc tgtctctccg gtttgtcatg 765601 ccgggtgcgg tctttgcgac tatcggctgg atcattgtca gcacattgtt ttcattttac 765661 gtcagcacgt ttgcgaacta tagcgccact tacgggagca tcgggggaat catcgttctg 765721 atgatttggt tttacttgag cggcatttta attatcctag gcggagaaat caacgctctt 765781 ttacataaac gtaaaaagct tcctgatgaa aatccctacc attagcgcac cctataaacg 765841 aacttcggtt caaaaagaag tcggggggat atcgtgatga ccaagcatac gaaaaaaggc 765901 ggaagccata acaaacaaaa ctcgaaaagc aaatcgagcc ataaaacaag cggaagcgcc 765961 aacggacaaa acggctacca ttagcataaa agcctcctga catgatgtcg ggaggctttt 766021 tgattaagaa gatgaagaat aggtttcagc cggtgaccag cttttcggtt tgcccagcac 766081 aagggccagc cacacagagc taagcgtgag agtaatgaag tagaacaagt ttgcgctttc 766141 aaatgtctgc atataccagc cgccggcaac tgggccgagg atgctaccga gactgaatgt 766201 aatgccgcaa agcaggtttc ccgccggcag gaggtgaggc ggaagaaggt ctgtcatata 766261 gctgatgcca agtgtaaagg ttgatccgac tgccattcct gcaataaaaa agcagccgcc 766321 gatcacgtag ggcgaaggaa atacaccggc gatgaaaaag caaagagccc cagtcagtaa 766381 aatcaccagc agcacattcc gcctgccgta tttatcgctg aggatgccga gcggaaactg 766441 aaagataatg cttccaatcg caaatgcggg aaggatgatc gctactgcgt ctactgatat 766501 ccccaaacgg agcgcgtaca ccggaaagct tccgttcagc gccgtttcca gaaagccata 766561 gccaaatgta ggcataaagg caacccaccc aaacagcatg gcctgataaa atcgcctgaa 766621 actattgtct gatttggttt catgaggact ggtttccggg tatgcatttt gtagaaagaa 766681 aacaaaaagc cacgcaaaca gactgatgca gccggacacg ataaaaggaa gcgacggact 766741 cagcttgaca agcggcacca tgaacgggcc tgcggcaaag ccaaggccaa aggaaagccc 766801 ataaatagac aggtttcttc cgcgattttg ttttgatgac atggaggtca cccacgtttg 766861 cgtagaaaag tgaagcatgt ggtcgccgat tccaatgaac aggcgaagca ggaaccagac 766921 ccaaactgac tgaagccaaa taaatccgaa taagcttaaa atgacaatgc ttccgcccat 766981 gacgatcagc ggcttgaacc cgagctttct gagcggtgct tccataaacg gcgaagccaa 767041 aagcacaccg atatacagcc cggtcgcgtg caggccgttg atagcagcgg attctccatt 767101 tgtttcaaaa atgattgaaa tgacaggcag cagcatgcct tgtgaaaacc cggaaatgga 767161 aacgagcaag acaaggataa agaaatgaaa tcgtgacatc gtgtcagttc tccttatatg 767221 gaatctatgt tgatcgtaca acgttttcca aaagcaggca acctgaaaaa agcctatatc 767281 acgctataca tttgccctcg tgtaatcatg aaggtttttg tgaagaataa aaataaaaca 767341 agtcataaaa aaggagctat ttcaccatga atcgtatctt ttttatttta gtggcggccg 767401 gtgttccgct ttctgtgatt ggcagtttga tgcattggcc ttccgcggtt ctatttgcag 767461 tttattgcgt gacgattatc gcgcttgcaa gctatatggg gagggcgaca gaatcactgt 767521 ccatcattgc aggaccgcgt atcggcggtt tgttgaatgc aaccttcggg aatgcggtgg 767581 agctgattat ttcccttttt gcattaaaag aaggcctgac aggaatcgtg cttgcctctt 767641 taaccggttc agtgctgggg aacctgttgc tggtagcggg cctatcgttt tttgtcggcg 767701 gtttaaaata taagcggcag gaatttaata tccatgatgc ccgccataac tccgggcttc 767761 tgatttttgc catcattgtc gcctttgtga ttccggaggt attctctgtt ggtatgggaa 767821 acgccagcaa gctcaattta agcatcggca tcagcatcat tatgattctg ttatatgtgg 767881 cggcgctgta ctttaaactt gtcacgcatc ggggcgttta tcagccgaat aatgccgctc 767941 agactgaaga agaggaagag ccagaatggt cagggaaggt tgcgacgatt gtcttgtttg 768001 cggcaacgat tgtggttgca tacatatccg aaaacctggt ccataccttt cactcggtgg 768061 ctgaacagtt cgggtggagc gagctgttta ttggggtcat catcgtggcg attgtaggaa 768121 atgcggcgga gcatgcgtca gcgattatta tggccttcaa aaataaaatg gacattgctg 768181 ttgaaattgc agtaggctct acgctgcaga tcgctatgtt tgtcgcaccg gttctcgtca 768241 tctgttctat cttttttccg acaagcatgc cgcttgtatt tacattgcct gagctcgtcg 768301 cgatggtatc agcggttctc ttgatgatcg cgatttcgaa tgacggggat tccaactggt 768361 ttgaaggggc gacactgctt gctgcatatg tcattatggc gatcggcttt ttccttcttt 768421 aacctgaaaa aatgatggat aacaacaaag cgggatgaaa agactaaggg aaaatgccat 768481 agaaagagtg atatgatgaa aaagctattt cattccacac ttattgtgtt gttattcttt 768541 agttttttcg gcgttcagcc catccacgcg aaaaagcagt ttaaggttcc taattctgtc 768601 gcaagcattt caaaggaaaa cacgtatccg aatgcttcac aggatcagcc aatgcttcag 768661 ccgagcaagc tggcaaagga attgctcgat cattctgagg taaagattga aaatccgcat 768721 ctcatcaaaa tgctgaatga atccaacata tccggcacac cgcttgcagt agggtaccgg 768781 gcgacaatat ttctcgggaa atgggcgctc ggctatgaat caaatgaaac agtcgcaaac 768841 tgggaatata aaaaaatcaa tacaaaccgt gcggataacc gcggcgggaa agaaacggct 768901 gaaatgcatt atgcccagga acagcagtac agagtgaagg gcggcttgac agctaaagtt 768961 ccaaatgctg aagatgtcaa aagcatgatg atgcaaaaag caatgaagaa aacgaacctc 769021 ccgcttgcat ttgagacggt catcggggct ggcacaaaac gggatcagat ttataaagtc 769081 gctcctaaaa aaatcggtta tctacatgca tatgcaccgg ctgtgaatga aaaaggaaaa 769141 gtgacttacg gagaagtgta cttagtgctg aaaggaaata aacgaaaact cgtcgtgaaa 769201 aatgtcacgt cacagggaat cggcgcgtgg attccggttc aagatcatgt cacgtttggc 769261 tttcagcttt cctcactgcc aagataaata aaaaactgat tccaactcgg aatcagtttt 769321 tttgtttatt gggttctctc gattcggacc gcttcctcaa gcatttgcac attgttttgg 769381 tagagctggc gaacgagaac ccgtcttact gcaaggctgg cactgaaata atcatcatct 769441 ttcaccatgc ctttaaccgt aaattcgacg ccgcgattga ttttattcaa tgcggtgatg 769501 ccgtggattt gaaacggttc tgtcggattg ccgaattcat cccgcttcaa tgaatcacga 769561 agctcttcat tcagcatgtc acatgcctct tccaacacgc tgtacacgcg gtccggatct 769621 tctttaaagc tgataagaaa ggattcggta atccgcataa aatcaatatt atagttctct 769681 atttgtctga cctcgccgtt gctgatggtg agcagcttcc cgctccattc ccggatttgc 769741 agcgagcgga ggccgatttc ctccactgtc ccgttgaaca agttgttgac ggtgacataa 769801 tcgcctttgt gcagctggcg ttcatatatt aagaatacac cagccagcac atctttgatc 769861 agcgattggg cgccaaaacc gatcacgata cctgctacgc ccgccccggc caatatcttg 769921 ccgaaatcat gcacaaataa agaaataacg taaaagataa aaccaattgt tgccgtatac 769981 tgggtgacag aacggacaag gctttcaatc gttttttcct ttttttcttc aataaagtcc 770041 gtccgtttaa aaaatagctg taccagccgg ttgatgataa agacaccgat ccaaaggata 770101 acggcaacga ggagaatatc gacgatttta ttttgaaaaa tctccgtaag tgtttctttc 770161 atccgcatct aactcctggc ttgacgtttt gtgaagtctg tatcctgata ataactgttt 770221 ttgacaagaa cattcggtcc gaggcaccgg acattcgggc agtggcaact cagttctttc 770281 gcaagcttgg tctctctcca cttttcatag gcggaaggga ggctgtccgt ctgaatgttg 770341 ccaagcggcg gggtatcacc gaaatcggtc acgataatgt ttccgtcgaa aatgttcaca 770401 ttcaggcggg atcggccgtc agggtcattt cgcactgtga cgtttttcgc cgcgcgaagc 770461 cggcgaagca gcttttggtc gtcttcgtcc ggactgcagg cataaaacgg cagcgttccg 770521 aacagcatcc acgtattttc atcacgaata tccagcaagc ggtgaatggc ctgtctcatc 770581 tctttcaggc tgagggattc aagagcgctt gcgaaatcgc ttggatacat tgggtggacc 770641 tcgtgacgct gacatttcat atcttctgtg atttggcggt gaatatgctc aatatgcgga 770701 agtgttcgtt tgttcagcat cgtttccgca gataccatta ctccggcatc cacgagcgtg 770761 cggctgtttt cgatcatttt ttcaaaatag cgcgcgcgct gttcgaaggt cggttttctg 770821 tccatcatgg caaagccgat ttcagcaaaa tcttcaactg ttccccagtt atgtgaaata 770881 tgtagcacat cgagatacgg aatgatccat tcgtaccgct cgatgtcgag ggtcagattt 770941 gaattaattt gtgtccgcac accccgttca tgggcatatt tcaataaagg aacaacatat 771001 tcttttactg atttcaacga aagcatcggc tctccgcctg tgatgctgat ggatctgagg 771061 cgcgggattt cctccagccg ttttaacaga agatctattg gcagagcatt cgggtcttta 771121 ggctgcaatg tatagcctac agcacaatgc tcgcatctca tattgcacag tgtcgttgtt 771181 gtgaattcaa cgtttgtcag ctgcatgtct ccgtattggt caacatccat ataggcttcc 771241 caagggtcaa actcgggcgt aatcggacgc agcttcgtgt tttgtgtcat gactatctaa 771301 ctcctttata aatgggcata ctaacgctgc caacagttaa ttttagacct gatttgccaa 771361 gatcgcaagt agcgcggcga ttgaaaaacg gcaaaaaatg agctaccata ataaaaaatg 771421 aatggaggaa cagaatgggg aacgccgtaa acaataaaga tcagcagatt gattatttaa 771481 agaacagact tgacatgttt atgaacgtca tcgattcatt agaccctgaa gcaaccgacg 771541 ttgaagatat agacaggctt atcagcatgc ttgatgacct ggaagccaaa tacgaacgtt 771601 ttaaaaaaga ttgggaataa aaccgcgtgc ccgccgcggt ttttttattg gcataaagca 771661 acagtataaa acaaagtctc tatctgtaaa ataagaaaaa atgcagaagg agcgctggcc 771721 atgaagtgga tgtgttcaat atgctgcgcc gccgtattgc ttgccggagg tgcagcacag 771781 gcggaagcgg tgccgaatga gccgattaat tggggcttta aacgaagtgt caatcatcag 771841 ccgccagatg ccgggaagca gctgaacagt ttaattgaaa aatatgacgc gttttattta 771901 gggaatacaa aggaaaaaac gatttactta acgtttgata acggatatga aaatggctat 771961 acgccaaaag tgcttgatgt cttaaaaaaa catcgcgtaa caggaacgtt ttttgtcacc 772021 gggcatttcg taaaggacca gcctcagctg atcaaacgaa tgtcagatga gggccatatt 772081 atcggcaatc attcctttca ccatccggat ttaacgacaa aaacagctga tcagattcag 772141 gatgaacttg attcagtcaa cgaagaggtt tataaaatta cgggaaagca ggacaacctg 772201 tatttgcgtc cgccgcgcgg cgtgttcagt gagtacgtac tgaaagaaac gaaacgcctc 772261 ggctatcaaa ccgttttctg gtcggtcgct tttgttgatt ggaaaatcaa caaccaaaag 772321 ggaaagaaat atgcctacga tcatatgatc aagcaggcgc acccgggagc catttacctg 772381 cttcacaccg tatcgaggga caatgcagaa gcgctggatg acgcgattac agatctgaaa 772441 aaacagggct acacttttaa aagcattgat gatctgatgt ttgagaaaga aatgaggctg 772501 ccgtctttgt aaaagagaaa gacctctcct taaacggaga ggcttttctt tattttatac 772561 atttaatcag tgcggcccag tccagatccc cgaagccttt ctcaatcccg ctttcaaaat 772621 ggctcttggc cagctcggca agaggaagat ttgcagaaac ccgttttgcg gcggcgagtg 772681 ccaggttggt atccttcagc cctaaagaca ttttgaagcc ggccggctca aatttctgct 772741 cggccataat ggttccgtaa ttttgataga ctggagaacc aaagagcgcg ctggcgattt 772801 ctaaaaattg tttttgttct aagccgtatt tctccatcat taaaaaggat tcagataacg 772861 cctccagcat ggacacaagc aagaaattaa tgctgatttt ggctgcattt gccgtcttgc 772921 tttcttcgcc gacgtcaaat atctgctggc tcaggctgtc gagcagaggc ttggcagctt 772981 gctttgcttc cgccggtccg gctgttatga tacggagcgc ggctttggct gcggcatccg 773041 gtctgccaag gacaggagcg gcgagaaaaa attgtccttt ctctgcatga gccgctgcga 773101 gcttttctga gaactcaaca ctgattgtgc tcatcgagat gtgtatgccg ttctctgcta 773161 atccttcaag cagcccgtct tctccgaatg tcacggtgct gacagaatca tcatctgcaa 773221 gcattgtgat gacaatatca gcggactttg ccgccagccg cggcgtatca gctgcctgtg 773281 cgccttctgt gacaaggtct tctgtctttt gtttcgtccg gttatagaca gtcaattcgt 773341 agcctgcttg aagaacattt cgggcaatgg gctgtcccat attgccgagt ccgatgacag 773401 caattttcaa tctaatcact ccctgaatat tttttccatt ataaacaata tgaacagaat 773461 atgcatagcg atcggcttac aacaaaaaag aacagctgct cgctgtcctc atttaaaaat 773521 attgaaccat cctttatgta caaaccaaat cagcattcca atcacaagcg cggccatcag 773581 gccaagtaca gcgaaatatc cgtatttcca atgcagctcc ggcataaagt cgaagttcat 773641 accgtataca ccggcaataa aggtgagcgg gatgaaaatg gttgatacga tcgtcagtgt 773701 catcataatc gcattcatcc ggtttgagtt tagcgtcacg tagctgtcac gcaagtcgga 773761 cgtcatgtca cggttggatt ccacaatttc agacaacttt aacaaatgat catatatgtc 773821 gctgaaatag gctttcgttt cccgctgctc tttcacatgg tcaaggctta aaatccggta 773881 gagcaaatca cgcatcggga taatcgtccg tctcaaatgc aataggtctg ttctgagatc 773941 aaacacctcg ttcatcagcg ttccatacgt tttgtgggga cggctttctt caatttcatt 774001 cagccggtct tcaattttat acacgagagg aaaatattca tcaacaagct gatccatgat 774061 catataagaa atatgcccgg gccctttttt caatatgtcc ggtgaagcat acaaacgctc 774121 ccggacttta gcgataccgg gcgtttcgtg taaatgaaag gtgacgacaa atttttcgcc 774181 ttgaaagata tcgacttcct ccgtctcaag tgtttcctta ttcagcgcat gaatcacgta 774241 aaaacgatag ccgtcataat ggtcaagctt tggccgctgc atatgctgga agcaatcctc 774301 aatggcaagc gggtgaaaat gaaaaaaatc tctcaataac gccgtttccg tatcctccgg 774361 gccgtaaaaa tcaacccagt accatgcaat atcaggctgt tccactcgtt cgatcggtat 774421 atttttcagc agctgatgct ctgttgtgat tgcggtaatg ttgatcataa acaaccctcc 774481 acctgccatt atatcatgcg gtctttatga gaaaagtata cggtactctc tgcctaattc 774541 cagcggcatg ttatactgaa caaaaacgga aaaaagggtg gatctcatgt ggaaggaaaa 774601 agtatctgtc acgcctccgt atcattttga ccgcgtgctg gacaggctgt ctttagaccc 774661 cctcaatgct gttgatcgag aggcgaggga agtccgtgtg ccaatcagaa atcaagcggg 774721 ggacgtatgt attgtaaagg tacaggcgtt aggccatgcg ggcgagcctg agttcctcgt 774781 cagcggggaa acggatcagg gagaaatgat gaaggaaatc aagcggattt ttcaatggga 774841 aaatcatttg cagcacgttc tggatcattt ttcaaaaacg agcctgtccg ccatttttga 774901 agagcatgcc gggacgccgc ttgttctgga ctacagcgtg tacaactgca tgatgaaatg 774961 cattatccac cagcagctta atctttcctt cgcttacacg ctaacagaac ggtttgttca 775021 tgcgtttggc gagcagaagg atggcgtgtg gtgctatcca aagccggaaa cgattgcgga 775081 actcgattat caggatctgc gtgatctgca attcagcatg agaaaagcgg aatacaccat 775141 tgatacatca aggatgatcg cagaaggcac actcagcttg tcagagctgc cgcatatggc 775201 ggatgaagac attatgaaga aactgatcaa aatcaggggt atcggcccgt ggaccgtgca 775261 aaacgtcctc atgttcggac ttggccgtcc caatttattc ccgcttgccg atatcggcct 775321 ccagaatgcc atcaaacgcc actttcagct ggacgataag ccggcaaagg atgtcatgct 775381 ggcgatgagc aaggagtggg agccttattt aagctatgcg tctttgtatt tgtggaggag 775441 tatagaataa ttcgtctgac aatgaaggaa atcctgcaaa cgtgttatac tagaaagatg 775501 tgaaaaaacc atttcacttt ctgccatccg cagaaagctt catatagaaa cggagagaac 775561 aacgtgaacc aacaaaagaa acaggcgccc gtcgaactga aggtcggaca aacttttccg 775621 ctgacgatta agcgtctcgg cattaacgga gaaggtgttg gctattttaa gaaaaaagtc 775681 gtcttcgtgc ccggcgcgct tcctggcgaa gaagttgttg tgcaggccac aaaggtccag 775741 ccgaagtttt cggagggccg cattaagaaa atccgcaagg catctgagca ccgggtggca 775801 ccgccttgcc ctgtttatga acaatgcggc ggctgtcagc ttcagcacct tgcatacagc 775861 cagcagcttc gggaaaaacg tgatatcgtc attcagtctc ttgaacgcca tacgaagttt 775921 aaagttgaaa acatggaaat caaagaaacg attggcatgg acaacccgtg gaattaccgc 775981 aataaaagcc aattccagat cgggcgctcg caaagcggca gcatcatcgc cggcttatac 776041 ggccttgatt ctcatgatat cgtgccgatt aaagactgta tcgttcagca tccggcaacg 776101 aacaaaacaa caggcatcgt ccgccgcatt ttagaggact tcaatgtgtc tgtttataat 776161 gaaagaaaac gaaaaggcga cgttcgcacg atcgtgacga gagtcggctt tgaaacaggc 776221 gaagtgcagg tcgtgcttgt aaccgcaaaa gaaacgcttc cgcacaagga agaaatcgtc 776281 aaagcgattc aaaagcgatt gccagaggtc aaatccatta ttcagaatgt aaacggggcg 776341 aaaacctcag tgatttttgg tgagaaaaca aaacagctcg ccggaaaaac agtgattcaa 776401 gaagtgctcg gcgacgtatc ttttgaattg agcgcccgcg ctttcttcca gctcaatccg 776461 gaacagaccg tcaagctgta tgatgaagtg aaaaaagcgg cgcagctgac cggaaaagaa 776521 aaagtcgttg atgcgtattg cggcgtcggc actatcggca tgtgggttgc ggacggagcg 776581 aaggaagtcc gcggcatgga cgtcatcaag gaatcaattg acgatgctaa gaaaaacgcc 776641 aaaaaacacg gcatggcaaa tgccacatac gtaacaggaa cagccgagca ctggctcccg 776701 aaatggacga aagaaggctt ccgcccggac gtcgtcattg tagacccgcc aagaacgggc 776761 tgtgacagca cgttcttgga cacgatcaaa aaagtcaaac cgaaacgctt tgtctacgtt 776821 tcctgcaatc catccacgct tgcgaaagat ttgcagacgc tgtcgaagga ctatcgcgtg 776881 gactatattc agcctgtcga tatgtttccg cagacggcgc atgttgaagc agtggcgagg 776941 cttgtattaa aatcgtctaa ctaaaaagaa catttcccag tcataaaata gttttcctaa 777001 taagacctgg atttcggtaa aataaacaat tccgatttcc gggtcttttt cgtgcgcagc 777061 tcttgtccta acggtctgtt ctcaatttta tcttccttct tttcgcggag atctttattt 777121 taactggcga aaagaattga aaaaacgtgt tgaaaagcag gtgaaaaaaa gcgttattta 777181 accggaaaaa tatcctccca gtatgtttaa aatacatgag tagaatgatg taaaatcata 777241 gatgtatttt cataatttgt aaaattatat attgacttgc agttattacg tgtgaaatat 777301 tgatgatagg aatataagga aagtatggcg tatatcattt caagagtcat tcgatgtaaa 777361 aagttgaaac attgtaataa atgaaagagg tgaaaatgat ggccaacccc attttaaaat 777421 gcataacgta tgagcactac aacaattaaa taatagtgcc gagacgataa caactattac 777481 agtaatacct acaatggtta tatccttgcg acaatcatgc ttcataatat aatgatttta 777541 gattgacact tggctaaaaa gtattgcaga gaaggaaatg gataattaaa tggataaagt 777601 atataaaaga agttggtttc aaacattttt ggcattttta gtatctcagc tttattttaa 777661 ttttgtagaa ttaacgggat ggggtcctaa gtatagagaa atgaatggat tcccagcaaa 777721 catagttgaa ctagatttct ttcaaacata tctttcattc tatgataatc catggtttaa 777781 tattattact gttttcttgg gagttttcac tattatacaa ataattacag ggataacaaa 777841 ggatattcga aattaaagca ataacttctg atgccttatt taatgatgaa agaaaatgta 777901 cactttctta attatcttat gagtgaagac tgcgacactt agtcagcagt ctattttatg 777961 gttctggatc aggattaccg aattataacc ctatacaaat atatagtagg ttgccacttg 778021 ctgcgttggt tattttctaa atcatgagca aatcccaaat gattcagatt gaagttcttg 778081 aattctttta aataagggtt tattttctct tctcatcctc tttactccat gtgattcaca 778141 agtggtagca gcttaagtag gttttttcat tctcttgagt actcagttat accaccccca 778201 actcaatttg ctttatctct attagttttt ccgcaaatat gatatagaga tacggatatg 778261 gtgtagtgtt aaatatctta tcttcaataa cagggcaatt attttgcgtt ggtaatatgg 778321 agaactcata tgatattcta tttaggttgg aatccttttt atccaaaaag ttcaaaagca 778381 aggccactaa gaaagacgaa ggtcagcgcc agttaaccag aatataaaaa atagggtaga 778441 taatcatccc acgtgaaatc ttcaaaattt actatagatt gataagaaat gctttcgcat 778501 gcgataagtg taaaagaagc atggtcagtt tttaatttgg gataaaggtt cagccgtatc 778561 ccataatgaa aggatttgat ttttgttatg acagaaaatt tctggcgtga attaccacgg 778621 ccgttttttg tactggcacc aatggaagat gtgacagatg ttgttttccg gcatgtagta 778681 agtgaagcag gcagaccgga tgtgtttttt acagagttca caaactcaga gagctattgc 778741 cacccggatg ggaaggatag cgtgcgcggc cgtttgactt ttacagagga tgaacagcca 778801 attgtggccc atatatgggg agataagcct gaaaacttcc gtaaaatgag tattggcatg 778861 gcagagttag gatttaaagg actagatatc aatatgggct gccctgtgcc taatgtggcg 778921 gggaatggaa agggaagcgg ccttatttgc cgtcctgcag ttgcggcaga attaatacaa 778981 gctgcaaaag cagggggatt gcctgtaagc gtgaagacaa gacttggata cacggatgtg 779041 gatgaatggc gcgagtggct gacacacatt ttgaaacagg atattgcgaa tctttctatt 779101 catctgcgta caagggcaga aatgagcaaa gtagatgcgc attgggagct catcccagag 779161 attaagaaac ttcgtgacga ggtggcacca gatacattgc taacaataaa cggggatatt 779221 cctgaccgtc aaactggctt gaaacttgct gaacaatacg gcgtcgatgg aattatgata 779281 gggcgcggta tttttacaaa tcctttcgct tttgaaaagg agccgaaaga gcatagcagc 779341 aaggaattgc ttgatctctt aaggctgcat ctggatctcc atgatgaata ttcaaaagaa 779401 gaagcccgtc catacaagcc tcttcctcgc tttttcaaga tttatctccg cggattccga 779461 ggggcaagtg aattaagaaa tcaatgcatg aacacaaagt caacagatga agtgcgtgca 779521 ttgctcgacg actttgagag aaagtatctt gatgggatag agtaacagca gtgcttgatt 779581 caaaaaaggc taacaaaata aagggatttt tacacaattc ttgactaaaa taaacctgga 779641 ttttcggtaa atccgggtct tttttgtacg cagcttttac tcagcctgtc ttttctctaa 779701 tttattgtaa gaaaataatg gtatatttag tggagatatc atataaaggg ggagaggaaa 779761 atgaaacggc tatgcatcat cccctgcggc aagaaaaaaa tctgggatgt ccagcctgat 779821 gccgggccgg taagagcaga ggacgcttat ctcagcccgt ttcatcaggc gtgcgagcgg 779881 tatgcaaaaa catttttcga tgagtgggtg attttgtcgg cgaagcacgg gttcctccgc 779941 cctgatgatc tcgtttcggg aaattacgat gtcacttttg gcaccggtca tccggaaatc 780001 atgacagcgg acgagctgcg ccgtcaattt cacgaaaaag gcttttctga tatcgaagag 780061 ctagtcatgc ttggcggaaa aaaatatcga agcgttctaa acgccgtcat cggagaacac 780121 cagcatatca gctggccgct atcatcatac aaaggcatag gctatatgct ccaagcgctg 780181 aaccgggctg ttgaagaaaa gcatgaactg tagcacgtac atatgaggaa aagagtggga 780241 acatgaaaaa acttgtgttt ggcttgcttg ccattgtgtt attcggatgc ggactatata 780301 tctatcatgt atggttcggt gatccatttt cgaaaaatgc tgcagaacag aagctagtgt 780361 cttatgtgaa acaaacctat cctaagaaag aaatcaagat cacgaatggg gtatataacg 780421 ctaaaacgtc tgaatatgta tttgaagcaa cctcccaatc tcatcgctac ccaatgtgta 780481 cgaagggatt tctgcatcct aaagtaacgt gcgatggaat tgaagaagcg tataccgaat 780541 cagtagcaaa acatgtaaat gaagaagcaa cgaaggcaat cgaagcagat ctgaaaaaag 780601 cggttcctcg atttataaaa gctgatgctg ctttgagtat cgaaaacgga cagttcacgt 780661 tagatacaaa atggaacaaa aagctggctg aaaaagcgcc tatgagcatg acgattcagt 780721 tagacgccag cgggttatca aaaacagatg ccgcaaagat ggcggaaacg gtcagaaaaa 780781 cgcttaatga aaagggatat acatactcaa acggcacgat agactgtatg cagaaggacg 780841 gggacggcgg tattggatat gtcaaatatt caattgattt tctttcaaaa gcagctattc 780901 agtcaaacga tgcagaggaa ctaggaagtt aaaaagattt ccaaggaaat aaatacgtcg 780961 atcattgtca aaggccgggt gatatccggt cttttttttg catgctgtaa aacgagacaa 781021 atgaatcagt ttgagacaaa acgagacaca cgtctcaaac tgtctccaaa gtgaagatga 781081 gaagactgat tttacgggct caaaagactg gcacacttct tgcatttata atggtgaacc 781141 ctaaatagaa ggaggcgcac aaaatgaaat tgttaaaacg agaaggcttg tcattaactg 781201 aggaaaaagc gctgtggatg taccaaaaga tgctggagat caggggcttt gaagacaaag 781261 tgcatgaact gttcgcccag ggagtgcttc ccggattcgt tcatttatat gccggtgagg 781321 aagccgtggc tgtaggggtg tgcgctcatt tacatgatgg cgacagcatt acaagcaccc 781381 acaggggaca tggacattgt atcgccaaag gctgtgacct ggacggcatg atggcggaaa 781441 ttttcgggaa agcgaccgga ttgtgcaaag gcaagggcgg ttctatgcac attgcggatc 781501 ttgataaagg catgttaggc gcaaatggaa tcgtcggggg cggctttacg ctcgcatgcg 781561 gatcagcgct cacggctaaa tataaacaga ctaaaaatgt aagcgtttgc tttttcgggg 781621 acggggcaaa taaccaaggt accttccacg aagggctgaa tttagcggct gtatggaacc 781681 ttcctgtcgt atttgttgct gaaaacaacg gctatggcga agctacccca tttgagtacg 781741 catcagcctg tgattcaatc gccgatcggg cggctgctta taacatgccg ggggttacag 781801 ttgacggcaa agatatttta gcagtttacc aggcagccga ggaagcgata gaaagagcaa 781861 gaaacggcgg cggcccgtct ttgattgaat gtatgaccta cagaaactac ggccatttcg 781921 aaggagatgc ccaaacctat aaaacgaagg atgaaagagt tgagcacctt gaagaaaaag 781981 atgccattca aggttttaaa aactaccttt taaaagaaac agatgctaat aagctgtcag 782041 acattgaaca gcgtgtcagc gaatcgattg aaaaagccgt ctcgttcagc gaagacagcc 782101 catatccaaa agattcggag ctgctgacag atgtgtatgt gtcatatgaa aaaggaggaa 782161 tgtaagagat ggcgagagtc ataagcatgt cagacgcgat caatgaagca atgaagcttg 782221 cgatgagaaa agacgaaaat gtgcttttga tcggtgagga tgtcgccggg ggagcggcgg 782281 tcgatcattt gcaggatgat gaagcatggg gcggtgtatt aggggtcaca aagggactcg 782341 tacaggaatt cgggcgtaca agagtgctgg acactccgat ttctgaggca ggctatatgg 782401 gagcggctat ggctgcggca tcaaccggtt tgagaccgat tgccgagctg atgtttaacg 782461 attttatcgg cacgtgcttt gatcaggtga tcaaccaagg ggcgaaattc cgttatatgt 782521 tcggcggaaa agcgcaagtg ccgattaccg tccgcaccac atacggagca gggttccggg 782581 ccgctgccca gcattcacaa tcgctgtatg gccttttcac gagcatccct ggactgaaga 782641 cagttgttcc atccaatccg tatgatgcca aaggtctttt gcttgcagca atagaagata 782701 atgatccggt gtttttcttt gaagacaaaa cgtcctacaa catgaagggc gaggtgccgg 782761 aagattatta tacaattccc ctcggaaaag cggatatcaa acgcgaaggc aatgatgtta 782821 cgctctttgc agtcggcaag caggtcaata ctgcgcttga agcggctgca cagctttcag 782881 agaggggcat cgaagccgag gtccttgatc cccgcagtct gtctcctctg gatgaggatg 782941 cgattttcac atcgttagaa aaaacaaacc ggctgatcat cattgatgaa gccaatccgc 783001 gatgcagcat tgccacggat attgctgcgc ttgtcgctga caagggcttt gatttgcttg 783061 atgcgccgat taaacggatt acagcgccgc atacaccggt tccgttttca ccagtgcttg 783121 aagatcaata tttgccgaca ccagataaaa ttgtcagcgt cacgcttgaa ttgcttggcg 783181 agccggcatt gaattaaagg ggggacacaa atggcggtaa aagtagtgat gccaaaattg 783241 ggaatggcca tgaaacaagg ggaagtatcg atatggaata aaaaagtagg cgacccggtt 783301 gaaaagggag aaagcattgc cagcattcaa tcggagaaaa ttgaaatgga gatcgaagcg 783361 cctgaaaaag gaacgctgat cgatatcaaa gtgaaagagg gagaagaggt tccgcccggc 783421 acagctatct gctatatcgg ggacgccaat gagtcggtgc aggaagaggc gggggcgcct 783481 gttgctgaag acaatatgcc gcaagccgtc cagcccgtca aacaagaaaa caaacccgca 783541 gcctccaaaa aagatcgaat gaaaatatct ccagtcgcca ggaaaatagc agaaaaagca 783601 ggattagacc taaaacaact gaaaggaact ggaccaggcg gacgaatcgt gaaggatgac 783661 gtaacaaagg ctcttgctga acagaaaaaa gatcaagcaa agcctgtttc ggagcagaaa 783721 gcgcaggaaa tcccggtgac aggcatgaga aaggtcatcg ctgcccgaat gcaggaaagc 783781 ctggcaaaca gcgcgcagct gacgatcacg atgaaagctg atatcaccaa gcttgccact 783841 cttcaaaaac agctttcacc aactgcggaa gagagatacg gcacaaaact gacgatcact 783901 cattttgtct caagagccgc cgttctcgct ctgcaagctc accctgtgct gaacagcttt 783961 tatcaaaatg agcgcatcat cacacatccc catgtgcacc ttggtatggc tgtagccttg 784021 gaaaatggct tagtggtgcc tgtcatccgc catgctgaaa agctatcgct gattgaactg 784081 gctcaatcca tctcagaaaa tgccaaaaaa gcacgcgagg gacgtgcggg aagcgaagaa 784141 ctgcaaggat ctactttctc cattacaaac cttggcgcgt ttggagttga gcatttcaca 784201 ccgatactaa atccgccgga aacaggcatt ctcggcatcg gagcaagcta tgacacaccg 784261 gtgtatcaag gggaggagat cgtcagaagc acgatcctgc cactcagcct gacatttgat 784321 cacagagcgt gtgacggcgc ccctgccgct gcattcctga aggcgatgaa aacatatttg 784381 gaagaacccg cagcattaat tttataggaa aagcaggtga aaacgacatg acattagcca 784441 ttatcggcgg cggacctgca ggctatgcgg ctgcggtttc cgcggcacag cagggcagaa 784501 acgtgctgct cattgacaaa ggcaagcttg gggggacctg cctgaatgaa ggctgcatcc 784561 cgacaaagtc tttgttagaa agcgcaaacg ttcttgataa aatcaagcat gccgacagct 784621 ttggaatcga acttccggca ggtgcgatat cagtcgattg gagtaaaatg caaagccgaa 784681 aacaacaggt tgtcagtcag cttgtccaag gcgttcagta cctaatgaag aaaaatcaaa 784741 tacaggttgt aaagggaaca gcctcctttc tttctgaaag aaagctcttg atcgaaggag 784801 aaaacggaaa agaaatcaga gaggcggacc aagtattgat tgcctccggg tcagagccaa 784861 tcgagctgcc ttttgcccca tttgacggcg aatggatcct cgacagcaaa gacgcgcttt 784921 ctctttccga gattccgtct tcactagtca ttgtcggcgg cggtgtcatc gggtgtgagt 784981 atgcagggct gttcgccaga ttgggatcgc aggtgaccat cattgaaaca gcggaccggc 785041 tgatcccggc tgaagatgaa gatattgccc gtctctttca ggagaaactt gaggaagacg 785101 gtgtcgaagt gcatacttca tccagattag ggcgggtgga tcaaacggcc aaaacggcaa 785161 tatggaaaag cggtcagcga gagtttaaaa cgaaggccga ttatgtgctg gtggcgatcg 785221 gcagaaaacc ccgtcttgac ggattgcagc tggaacaggc cggagttgat ttttctccaa 785281 agggcattcc ggtgaatggg cacatgcaga cgaacgtgcc tcatatttac gcgtgcggag 785341 atgctatagg gggcattcag ctcgcgcatg ccgctttcca tgagggcatc atcgctgctt 785401 ctcatgcttc cggaagggat gtcaaaatca atgagaaaca tgtgccgcgc tgcatctata 785461 cgtccccgga aatcgcgtgt atcggaatga cagaacgaca ggcaagaagc atatacgggg 785521 atgtgaagat cggcgaattt tcattttccg caaacggcaa ggcgctcatt aaacagcaag 785581 cggaaggaaa ggtcaaaatc atggctgaac cggaattcgg cgaaatcgtg ggtgtctcga 785641 tgattggccc ggatgtaacc gagctcatcg gccaagcggc agcgatcatg aatggtgaga 785701 tgacggcaga tatggcggag cattttatcg ccgcccatcc gactttatcg gaaacattgc 785761 atgaggcgct gttaagcacg atcggccttg cggtacatgc ataataaagg aaaaagcagg 785821 cgcatggata taaggcgcct gcttttttat tgttgaaagc gctttatttt tcccctacaa 785881 tagatgaaaa cggcgtgtaa gggaggagcg atcaaggaaa tgaattcggt cccaaacgat 785941 ttgcaaacct ggaaacgttt tgtgaaagac ggtgtgcttg acgaagcccg attaagaaaa 786001 cggattgcag agtcatggca tcgctgcaaa aaagctgagg tcaatcctta tttagaaaaa 786061 ggcccgaagg ttttacagca aacggagctg gatcagcagt caaaaaaaca ttcattcttc 786121 ttgacgaccg caaagcctta cctcgaaaaa ctgctgcctg ccataaaaga aatggaaatg 786181 atggcgctgt taattgattc agacggtgtt gttctggcat tggacggcca tccgcgcgcg 786241 ctctatgaag ccaaacgcat caatttcgtc gaaggggcat gctggacaga aacggctgtc 786301 ggaacaaatg cgattggcac ggcgctccac atcagcgagc cggttgcaat acaaggatca 786361 gagcattact ctatcgcttc ccatctttgg aactgttcag ctgctccgat tcaccatgag 786421 gatggcagcc ttgcgggtgt aattgacata tcatgcccgg cggcaggcgc gcatcctcat 786481 atgcttggta ttgccacggc gattgcctat gccgctgaac gggaactcgc agctaaaagc 786541 cgtgagaaag agctggagct gatcagccgt tttggggaga gagctgcatc cagtgtgccg 786601 atggtgctct gtaataccaa gcagcacatc atcagtgcga gcatgccgat tcgaacctca 786661 atgccggatt ggcagggccg gcacctgtac gagttgaagg aacggggcta ttcaatcgaa 786721 aatgctgtca ccataggaga tggcggcact tgtttttatc tttcggaaca aaagaaaaag 786781 aaggcgtttc gattcaatgg agtgatcggg caaagcggcc gatcgcaagc gatgctgatg 786841 caccttgaac gagcagctgc gacggatgca tcggtctgtt tgtcgggtga aacgggtacg 786901 gggaaggagg tcgcggctcg cgcgcttcat gagaacagtg agagacggca cggtccgttt 786961 gttgctgtca attgcggagc gattccgtct gatttgattg aaagcgaact gttcggatat 787021 gcagagggcg cttttacggg agcgaaacga aatggctata aaggcgcctt tcaaaaagcg 787081 aatcaaggca cattattttt agatgaaatc ggagaaattt cccactcgat gcaggttgca 787141 cttttacggg tgcttcagga acgcaagata acgccaatcg gcgggacgaa agaaattccg 787201 gttgatatca gagttattgc cgccacacat tgtgatttac gcgagcttgc cgaaaacgga 787261 aaaatcagag aggacttgtt ttaccgtctt catgtctatc caattgaact ccctccatta 787321 cgcgatcgca ccgaggatat cccggatctc tttgagtact acaaacagaa gaatcattgg 787381 ccaggcgatc ttccttctga tttttgtaat gtgctgaagc aatggaagtg gccggggaat 787441 atccgcgagc tgtttaatgt gtttgaacgt ctttctatca gatttccgga cggccggctg 787501 agagatgaat cgcttcccgc tttactggaa gccgctggat tgccggccag ctctgcagaa 787561 aaaaagccgg ctgctgccgg cgtgcttact tttcgtgagc aaatccaaaa ggatatgatg 787621 atcaaagcgc ttgaatctgc aaaaggaaac gtctctcaag ccgcaaaaat cagcgggatc 787681 ccccgaagca ctttctacaa acgcctgaaa aaattcaact tgtccgctga atcataaagc 787741 atacttcctt caggaaatgg aaacgttatg tattgaagga gggtgttacg atgaatattc 787801 aaagggcgaa agaaattgta gaatctcccg acatgaagaa agtaacatat aacggcgttc 787861 ctatttacat tcagcacgta aatgaagaaa ctggaacagc aagaatttat ccgcttgacg 787921 aaccgcaaga ggagcatgaa gtgcagctga acagcttaaa agaggattaa acaaaaatgg 787981 cccgcttcat aagcaggcca ttttgttatc cgcgcggcgc aaataaaata acacagacac 788041 cgatgagaca aatgaatgcg ccgatccagt catacagatc aggtgttttc cggtcaacaa 788101 gccatcccca caggaccgca agcacgatga atactccgcc ataagcggcg tatacacggc 788161 cgaaagatgg gaaggactga aacgtcggaa gaatgccgta tacaatgagg atcagcgccc 788221 cggcgattcc gtagccagct ggctttgcct ctctcagcca tagccaaacc agatatccgc 788281 cgccaatttc agcaagccct gccgcgagaa ataaaagaat ggtaatcagc atcatgagca 788341 ctcctcaatt tgcatttatc tttcattata gaggaggaga gcttttaaag cttcggatga 788401 ttctcaaatt ccttcaaata cgcttttcgc tgaacctctg taaattggct gatccaattg 788461 ttttgagcct cttcattcaa atggggaagg atatagcgtt caaccgcttc gaaaaacagc 788521 ggattcgtga tgatgttcca ggtcgggatt cgaacgattt tgccgtctgt tttctcgatg 788581 ataatatcct caaaaaagat ccctttcaaa ctgtattgat ggcgtcccat ataaagccgc 788641 ttcacctcgg aaaacagcac gctgcgcttt ctcaagaaga tttcgccact aggtccggtc 788701 tttatggtga aaatgacatt tccacggctt gtgaacgcag gaaaagccat aaagaatgtg 788761 atcaatccat aaatcatcgc cagtaatccg ccgcccaaat aaagcagggc atatttagat 788821 tcaaacgtga gggcttcaga caccagccag actcccacaa taaaggcgcc ccctgtagcg 788881 aggaacagcc aagcccttag aaacatcatg ctttttactt caatcatgtg ctgcccctaa 788941 agcttcggat gattctcaaa ttccttcaaa tacgcactgc gttggatgtc tgtaaactgt 789001 ccgatccaat tgcttttcgc ctcttcattc agatgtggaa ggatatagcg ttcaaccgct 789061 tcgaaaaaca acggattcgg aatgatgttc caagtgggaa tgcgaatggt cttctgatcc 789121 acggtttgga tcaatatatc ttcttggaag attcctttta gactaaattt atggcggctc 789181 atctcaattt tcttgatatc agtaaacgta acagacactt tgtcagtgaa cacttctcca 789241 ttttttcctg tcttgatgcg gaaaatggta tttccccgcg gggtgaaagc cggaaagaag 789301 atgataaata aatataaaca aaacaaggtg aacagaaagc cagcaggaat ggctaatagg 789361 taatatttcg tttgaaacgt aatacccata taaaagagcc acaaacatgc taatcccata 789421 ccggcagatc cgacaaaagc ccatattctc aggaacattt tgcttttgac ttcaatgatt 789481 tcttggtttt tcaatgcttt tctccttttg ttaattcaat tcttatcatt ttgaaatgat 789541 ttgatttaca acatccttat gagcagggag gatagaaaat tcattctggg tgatgcctgt 789601 gacaagccaa gtatggtggg cccccggcag gacgaatgcc atgtcagcca cttcaggagt 789661 gttatctttt ccatatgcca gacgcataag tgtatccatt ttccctttcc gcaaagccag 789721 atcatttgca aatcgggtaa cgtcctcttg gtggtcatgt ttttcaagga actcttttag 789781 atatgaaggg ttgtctgaag cgccctccaa gagtttttca aattcatttg atgtcaatgt 789841 tacaatcgat tctcttttat cctctgtatc tattatatgt aaaaactcat ctgtcttagc 789901 aagtaaccct tcacttgatt ccatttttgt aatgcgatgg acttgttcat caaaaaggag 789961 ttcgtgagag taggtgccga attttgatac atggcatgac acattctgtt cggcaccttg 790021 cccgttaaat ttagaaagct tcactgtata gtcagcgtcg tttaatacat ggataaacgg 790081 acagtactcg tcctttaacc gatattgatg gttccgatat tccgctgcat ccttggctaa 790141 gagtgagcgg cacgcggctt caaataaggc gccgagctgt tcatcttcta tttccggaaa 790201 ataggcctgc ttcaaggcca ttccctgttc aaaaaaccct tcgctgtaaa agcaaaacaa 790261 gagttcttct atgctaattg taaactgctt cattgtttat tctcctatcc aaatgaaaat 790321 ttccctttaa ggaaatgggt tgcgccgtgt ataagcgaat ccgctgtttt ctttgctttt 790381 tccattcctt ttttcgcgct gtctatccct ttatgtatcg atttattcgc cgcatctatg 790441 ccgtcattca ctgatttgac gactttgccg gctgattcca gccctttttt ggctgtatca 790501 acaacagcat ggatcggttc tttcagcttt aaggctgctt tttcagcaaa accggctgta 790561 tatttggcga tttgttctcc gacgactccg ccaatgtatg aacctgctgc cccaagaagg 790621 acagtaccca caggtcctgc aaagcttccg attgcaccgc cgatgacagc accagctgtg 790681 gcaccgccgg caacaaaaat cgtattattc acagcattcc cgacggcctt ggcgttttca 790741 cgcttgagaa cttccggttt atcctggtat tttgcataat tttcagcaat tttcacgcct 790801 gctccgaatg tttcggtcgc tccggtaatc agtgtggcgg taatggcatt tcctttcgcg 790861 aatctcaagc ccgtttttcc cacatccttc aaagtggagc gtacgccggc ttcattaaga 790921 aatccttttg tgtagcttct gacgctgttt gaaaaatcca ccgtgtcctg aggaaagtat 790981 tttgtaaact ttttatgtac caaatctgaa aatggacggt ttgtcttttt caacaaatat 791041 ttaggattca aaagcactct tgccgctttt tgataacgtg agctgtcaac ggccctggaa 791101 atatccaaga gcagttttga gtgctgggct gtatgcaagc cgcttggttg tttcacaaat 791161 ttcgtaagcc ctaatccgta atattttccc tgcgtcagca taagagcggt taagcttgtc 791221 atcgtaccgt atttgtcgta ggcattgtag agctttcgca aaatatcatc ttgttccaca 791281 aatttatcgc ctgtttttct gatgaaaatc tcattgtcac tcagcttagt gacgagcgcc 791341 tttcctgagc tccacgcatc gcccactcca gaaaaacagc tgctgtagcg gggatcgcat 791401 tgcaaaatca tctgccccag ctccacatgc aggtccttat atttgttttc catatcagtt 791461 aattcagtga ctacatcatt tgcaagctgt tcgagcttat ccggatcaac tgcaatgttt 791521 cctgacacac cgttcacctc ccgagtttat gtctttcctc tcttgcttta cgctccagtt 791581 cttccattct ggcaatttca gcttttcgtt cttctatttt gacagcggca gccttcagct 791641 cttggcttgt ttcaagcagc tcctgttcga attgatcgta ggcggctttc gtttcctcga 791701 aatcctggtc aaacgaatct cttgctttgc cctgccaagc atctcccaat gcagataacc 791761 gggattcaag cagcattttg gagcttctga cctcttctgc ggccgcacta tacttgtttg 791821 ccagctcaat gactttatat gagtccaact tttgtcccct gccttttcta aattcacgca 791881 caattggatg ttttatataa atgattataa ataattcggc atgtatccga atcgtacaaa 791941 agaacctttt cataagaatt ggaagggcgt atattcactt aaaattcaca gttggtgaga 792001 ctttaagatt acaaaaaagg taaaaaaacc aaatctctca gacataaggc aaatgagaaa 792061 tttcccgctc tatgggaaaa aacactaaag ttgatcaaat gacctaagtg cgccaaacgt 792121 gttacgggac gagctatctc atggtataaa tggaattgta aacgttatca aggaggtcgt 792181 catatgaaga aaaaatcatt ctcaatcgta atagcgggcg gagggagcac tttcactcca 792241 gggatcgtac tcatgctctt ggaccatttg gaggagtttc cgatcagaaa gctgaagctg 792301 tatgataatg ataaggagag acaggatcga attgcaggcg cctgtgacgt ttttatcaga 792361 gaaaaagcgc cggatattga atttgcagcg acgactgacc cggaagaagc ttttacagat 792421 gtcgattttg ttatggcgca catcagagta gggaaatacg cgatgcgcgc gcttgatgag 792481 caaattccgt taaagtacgg agttgtcggc caggagacgt gcgggccggg cgggatcgca 792541 tacggtatgc gttcgatcgg cggtgtgctt gaaatattag attacatgga aaaatactcg 792601 cctgatgcgt ggatgctcaa ttattccaat ccggcggcaa ttgtggctga agctacgaga 792661 cgccttagac cgaattctaa aattctcaat atctgtgata tgccggttgg gatcgaagac 792721 cggatggcgc aaattcttgg cttatcctca agaaaagaaa tgaaggtccg ctattacgga 792781 ttgaatcatt tcggctggtg gacatcgatt caggatcaag agggcaacga tttaatgccg 792841 aagctgaagg aacatgtatc ccaatacggt tatattccga aaacagaggc tgaagctgtg 792901 gaggcaagct ggaatgacac gttcgccaaa gcgcgtgacg tgcaggctgc agatcctgac 792961 acactgccga atacgtattt gcaatattat ttgttcccag atgatatggt gaaaaaatca 793021 aatccgaatc atacgcgggc gaatgaagtc atggaagggc gcgaagcttt tattttcagc 793081 caatgtgaca tgatcacacg tgaacagtcc tcggaaaaca gcgaaattaa aatcgatgac 793141 cacgcatcgt atatcgttga tcttgcccgg gcgattgcct acaacacagg tgaaagaatg 793201 ctgttgattg ttgaaaataa cggtgcaatt gcgaactttg acccgactgc gatggttgag 793261 gtgccatgca tcgtcggctc aaatggacct gaaccgatta ccgttggcac cattccgcaa 793321 ttccagaaag ggctcatgga gcagcaggta tccgttgaga agctgactgt tgaagcgtgg 793381 gcagagaaat cgttccaaaa gctgtggcag gcgctgatcc tgtcaaaaac agtgccgaac 793441 gcgcgtgtgg caagactcat tcttgaggat ttagtggagg ccaacaaaga cttctggcct 793501 gagcttgatc aaagcccaac ccgcatatca taaatgaaat tcccccattt tcgaatctgt 793561 aattgtatat aatagaaaga aaatgggggg atctgatatg cagctcgaag aactgatcaa 793621 tcagcactac agcaaattga atgacaacga ttttcatatt ttaaaatata tattgaatca 793681 taagcacaca tgctatcacc ttggaatcga cgcgctggcc aaagcttgca gtgtatcgcg 793741 ttcctcaatt ttacggcttg cccaaaagct cggtttcagc ggttacagtg aatttcgcgt 793801 ctttttaaag tgggaagatc agccggaaga aggcgagagt atgagttttg aaaagctgct 793861 tgatgatatt gaagcaaatt tgaagttttt acggacaaag gacatgacgg acatgtgcca 793921 gctgattgat gcagctgacc gcattttcgt ctacggttct ggaaatgcgc aaaagatatg 793981 cgcccgcgac ctgcaaagaa tgtttattcc gcgccatcgc tatcttattt tgattgaaga 794041 cacaaatgaa tttaatttga tgcgcgatga ttttaaagtg aacgatctgt ttatcatcat 794101 ttctctttcc ggagaaacac cggagctgat tcctcaggca agaatgcttt ctgcaaaggg 794161 tattcccttt atttccatta cgaatttaaa aaacaatgtc ctcgcccagc tgactccgca 794221 taatctttat gcgacaagca aacctgtgac attaagcgat agaacggaaa ttgtcgcttt 794281 tgcaccgttt tttctcgttg gcgaagcatt gttccgcgca tatgttgatt acaaagaggc 794341 agaaaaaaat gacaatgagt agcagggggt tctggtatga tgcaaaaaat tcagcgcttt 794401 ggaagcgcga tgtttgtgcc tgttttatta ttcgcgttcg ccggcattat cgtcggtatc 794461 agcacgctct ttaaaaataa aaccctcatg ggaccgctcg ccgatcctga cggtttttgg 794521 tatcagtgct ggtatatcat tgagcagggc ggctggactg tttttaacca aatgccgctc 794581 ttattcgcca ttggcatccc ggttgctttg gcgaagaaag ctcaggcacg cgcctgtttg 794641 gaagcgctta ctgtctacct gacattcaac tattttgtca gcgcgatatt gacggtatgg 794701 ggaggagcat ttggcgtcga catgaatcaa gaggtcggcg gaacgagcgg gttaacgatg 794761 attgcgggca taaaaacgct cgataccaac atcatcggag ccatctttat ttcttcgatt 794821 gtcgtctttt tgcataatcg ctattttgat aaaaaactgc ccgattttct cggcatcttt 794881 caaggctcaa catatatcgt gatgatttcc ttctttatta tgatcccaat tgcgttggct 794941 gtgtcttata tttggccgat ggttcaatcg ggaatcggct cgcttcaaag cttcctggtt 795001 gcttctgggg cggtgggcgt ttggatatac acgtttttgg aacggatttt aattccgacc 795061 ggccttcatc actttattta cacgccgttt atttatggcc cggctgtagc ggaaggcggg 795121 atcgtcacgt attgggcaca gcatctcggc gaatattcgc aaagcgccaa accgctgaag 795181 gagctctttc cgcaaggcgg attcgcgctt cacggcaact cgaaaatctt cggtattccg 795241 ggtatcgccc tggcttttta tgtgacagcc aaaaaggaaa agaaaaaact cgtcgcaggg 795301 ctgctgattc ctgtcacact gacagcgatt gtcgccggta ttacagagcc gattgagttt 795361 acgttcttat tcatttcacc tttcttattt gcggttcacg ccgtgcttgc cgccacaatg 795421 tcgacagtta tgtatatggc cggcgtcgtc ggaaatatgg gaggcggact gattgaggcg 795481 gtaaccttga actggattcc gctctttggc agccacggta tgacatatgt gtatcaaatt 795541 ttgatcgggc tctcgtttac agcaatttat tttttcgtct tcagattttt aatcctcaaa 795601 ttcaatatcg ctacaccagg acgggaaaag gatgaacagc aggaaacaaa gctatattcg 795661 aaaaaggaat acagagaacg aaaaaacaag gatgaaacgg cctccgctgc tgaaacggct 795721 gatgacaccg cttttctgta tattgaagcg ctgggcggaa aagacaacat cactgaagtc 795781 acaaactgcg ccacccgcct cagagtcagt gtcaaggatg aaacaaaggt tgaacccgac 795841 agcgtattcc gcgcgcttgg cgcacacggc gttgtcagga acgggaaggc gtttcaggta 795901 attatcggat taagcgtgcc gcagatgcgg gagcgtgtgg aaaaaatatt gaatcaataa 795961 agactgccct ccttttcggg agggttttcg tttgccgtca aaaagaccgc catagtaaag 796021 taaagaaaga gacaatcgag taaaaagggg tttggaggct tttacatgca aaaggctttg 796081 tcgtttttaa aaccatattc attgctggcg ggaattgctc tgattcttat gctgacggag 796141 cttgcagttg aactgatgca gcctttattg attgcaaaaa tcatcgacga tgggatattg 796201 aagcaagatc tgcggcatgt atggatatgg ggcacggtca tgatcgggct gaccgtgtta 796261 tcctttgcgg cggggatgct gaattccttt tatgccgccc atgtcagcca aagcttttcc 796321 tatgatacga gaaaagggct ttttcaaaaa atccagtcct tctcctattc cacatttgga 796381 cagttttcgt cctcttctta tattacaagg ctgacaaacg acgtcacaca ggttcaaaat 796441 atgattttta tgagtttgcg gtttatgctg cgggctccct taatgattgc aggcggcatt 796501 gtgctgtcgc ttgccgttaa tgtgaaactc gggttttttc tgcttgtgac cattccgatc 796561 ctgatcttgt ttttgctatg ggtattaagg aaaggcgggg cactgttccg ctcagtgcag 796621 aaaaggctgg atcaagtgaa caccatcatg caggaaaatt taattgcaat caagctgatc 796681 aaagcgctgc ttcgcggcag ccacgaagtc aaacgattta tcaaagccaa cacaaggctg 796741 atggaaaaaa cggtttcggc ctttcagctt gtggaattca cgatgcctgt actgatgctg 796801 ctgatgaatc tctgcatcct tttgattttg tgggcggggt cctacagtat tacgagcgga 796861 agcactcagg ttggcgatgt tgttgcgata attaactacg caacacgaat tacaggcgcg 796921 ctttcgatgt ttccgttttt gattatgatt ttcacccggg cgaaggcttc aggggataga 796981 atcggtgagg tgcttgaaac agaaggcgac gagcgggagg aaggcaccat atctgatcgt 797041 ttgtcaggac ggattgagtt tcagcatgta tcctttcgct atcctgaaat ggacagagaa 797101 gcgctcagga atgtctcatt ttccgcaaag ccaagagaaa cgatcgcgat tctcggtgcg 797161 acgggctcgg gcaagtccac gctttttcag ctcattccgc ggctttatca gccggattca 797221 ggccgcattt acatagatga aaagccggtt caagatattc cggctgaagg gctgcgcagg 797281 caaattggat atgtaccgca ggaagtcctc ttgttttccg gcacaatcaa agaaaacatc 797341 gcttggggca aagaaaatgc ttcactagat gaaataatgg atgcggcaaa acttgcgcaa 797401 attcatgaaa cgattttaaa gctcccaaat ggatatgaca ctgttttggg gcaaagaggc 797461 gtcaacctgt ccggcggcca aaagcagcgg atttccattg cgcgggcgct gattcgaaaa 797521 ccggctatcc ttctattaga tgacagcaca agcgcgcttg atctgcaaac ggaggcgaag 797581 ctgcttgaag caatcagcac ataccattgc acaactttga tcattacaca aaaaataacc 797641 acggcgatga aagctgatca gattttgctg cttgaggacg gcgaactgat tgaaaaaggc 797701 actcacagtg agctgctttc tgaatctcag ttatacaagc gcatttacga gtcacaattc 797761 ggaagggagg ggagcgagtc atgctaaaag acatccgcaa gcctttccaa tatcccaaac 797821 tgccaattga caaaaaagaa ggcgcgaaaa agcgggcgaa agcaaaggat acaaagggca 797881 cactgagacg aatctggtct tacttggctg aaagaaaagg actgctcata cttgtcatgc 797941 taatggttgt catcagcgcc atattcggac tccttggtcc ctttgtgatc ggaaaggcca 798001 tcgaccattt tatcgtcggg aaaacggtca gcggcttgat tcctgttttg cttcttctgc 798061 tcgctatcta tatcattcag tccctgtcgc tttggtttca aaactattgg atgattacga 798121 tctcgcaggg cacggttttc agaatgagaa gcgaattgtt cacccatctg catgagctgc 798181 cgattccatt ttttgataaa cagcggcacg gcgagctgat gagccgggtg acgaatgaca 798241 tcgaaaatgt cagttctacc ttaaacacgt cagtcattca aattttgtca agtgtgatca 798301 cctttgtcgg gacgattgcg gtgatgctgt acatgagccc gctccttact ttgattacgc 798361 tgaccattat tccggtgatg gcagcgagcc tgaaatggat caccaaccga acgggaaagc 798421 tgtttaaaga acagcagaaa aaccttggtg atctgaatgg gtatattgag gaatctgttt 798481 caggcgcaaa ggtcatcaaa gcatattcac gtgagaagca gattactgct gaattcctcg 798541 aaaaaaacgc tgcactcaag acgtcgggct tttgggcgca gacgatttcc gggtttattc 798601 cgaaggtcat gaactctttg aataacttaa gctttacaat gattgcggca atcggcggtt 798661 tgtttgcgct gaaaggctgg atctcgatcg gctccatcgt tgtctttgcc gagtattcaa 798721 gacaatttac acgcccttta aacgatctgg ccaaccagtt taatacgatg ctgtccgcaa 798781 tcgccggcgc tgaacgggtg tttgacgtgc ttgatgaaaa agaagagcgc gaggatgaaa 798841 agaacgccgt gcatcagccc atccaaacag gcagcattga attccgggat gtgtccttcg 798901 gttacgataa agggcagcag acactgaagc atttacagtt taccgtgcct gcggggcagt 798961 ccatcgcgtt tgtaggaccg acgggggcgg ggaagacaac cgtcactaac cttctcgccc 799021 gtttttacga gcctaacgat ggaaaaattt taatcgatgg tacagatatt aaaaccctta 799081 ctagagcaag cctaagaaaa aacatggggt ttgttcttca ggattctttc ttatttcagg 799141 gaacgatcag agaaaacatt cgctacggca ggcttgatgc ttctgatcag gaagtcgaag 799201 ccgctgcaaa aacagcgaat gcccatagtt ttattgaaag gctgccaaaa gggtatgaca 799261 ccgtactgac gcaaaacggt tcgggcatca gtcaagggca gaagcagttg atttctatag 799321 cgagggcggt gcttgccgat ccggttcttc tcattttgga tgaagcgaca agcaacattg 799381 ataccgttac agaagtcaac attcaagaag cgctcgcccg tttaatggaa ggaagaacaa 799441 gcgtcatcat tgcccacagg ctgaacacca ttcaaagagc ggaccagatt gtggtgctaa 799501 aaaacggtga aatgattgaa aaaggcagcc atgacgagct gattcggcaa aaaggatttt 799561 acagtgactt atatgaaagc caatttgaga aatagacctt tgtcctgcac agaggtcttt 799621 ttttgttaca gttttatagt acttttattt cattttcgta aaatgtaaca aaattacttg 799681 acgtaaacaa gttatgtata tatactagct tacattaagt aagtgataac atttatcaag 799741 gaggataaaa tgaataaatc atttgaaatt ggcacattac ttttaagagt tattacaggt 799801 attatctttt ttgttcacgg tttatcaaag tttcagggaa tggagggcac catccaattt 799861 ttcggcagca taggccttcc aagctttatg gcgtatgtca tcgcagcgat tgaactgatt 799921 ggcggagtgc ttgtcttctt cggattggct acacgtattg tcggtgtact gttcgctctt 799981 acactgatcg gcgccatcat cactgttaag ctgaaagcgc cattcatggg caatgcagaa 800041 tttgattacc ttctgctttt gacatccatt cacctggcgc ttactggaag tcgattcctg 800101 gcgctggacc catttgtgtt taaaggaaaa aagaacggaa acgtttcagc ataagaaaag 800161 aggcatgcag catgaccagc attcatgagg atacacacat tggctatgcc aaactcacaa 800221 ttcgcagtct ggagcgttcg cttcagttct actgtaacgt catcggtttt caagtcttaa 800281 aaaagacgga ccgccaagcg gaattaacgg ctgacgggaa acgcgtactg cttattcttg 800341 aagaaaatcc gagcgctgtc gtcttgcctg aacggtctgt gacaggcctt tatcactttg 800401 cgattcttct tccggacagg aaagaacttg ggatcgcgct cgcccgcctg attgaacacg 800461 gcattgctat cggacatgga gaccatgctg tcagcgaagc gctctacctg tctgatcctg 800521 acggaaacgg cattgaaatg tacgctgacc gcccccgcag cacgtggcag cgtgatcggg 800581 aaggaaacta cgtcatgacg acaaccgctg ttgacattga gggccttctg gaagaggcag 800641 gagatgagcg gaaaacatcg cttccgaacg atacaatcat cggacacatt catctgcatg 800701 tcagtgattt gaaagaagca aaggcgtttt atacagatgt actgggcttt gacattgtcg 800761 gaaactatgc gggcatgtcc gccctcttcg tttcagccgg ggggtaccac catcatatcg 800821 gcttaaacat ttgggcggga agaaatgcgc cgcctaaacc gacaaatgcc agcggactag 800881 attattatac tgttgtcctg ccccaccaag aggagctgga tttggtggca aaccgagtca 800941 aacatgccgg gtattcgatt gaagagacgg aaaacagctt tcgtgtgaaa gaccctgttt 801001 ccggcgccta tattacattt gtgatttaac tgcaatcccc ttgccgaaat aacggcaggg 801061 ggatttttta tttttgtccg ccttgttatg atgagagaac caacttgtta ggaggcgttt 801121 acatggaact caaccacctt gtgacgggca aaatagcatt aaatcaatat gtgcatcgct 801181 tagagcaaaa ggatgtttca ttttacgtcc actactgggg agcgatgacg aaccactata 801241 acacactgct tcataagcat tccttttatg aaatttgtta cgtggtaaga ggtgaaggat 801301 attaccttga aggcgatcgt acatatccgc ttcgtgaaca gacgattttt ttgtcaaagc 801361 cggagcattt gcaccaaatc aaaagtgaaa cagggctgtt ccttttttac gtcgctttcg 801421 agctgagcga ggatcagtca agcgccgaat ggatcaaagt gatggaagaa gtgaaacaaa 801481 gcccctttat cacaatgcaa ttgaaagatg gcgaaccgcc gggcctgctt tggaaaacgt 801541 taatgctgca agcagcgcaa cctgtcaatg cttttgacaa agagatccta tctcatttgt 801601 cgcatgcatt gatcctgtca ttaatccaaa cctttctccc gtacgcccaa cgcccgaaac 801661 aaaagcagcc cattcacaca tcttctgctt tgctgacaga ggtgaaactg cacataaaag 801721 acaatctgtc acagccgtta aagctgacgg atgtcgctag ccactttcat atctcaggga 801781 ggcatttatc acgtttattt gcagcagaac tgggcgtcag ctactcagaa tttgtccaaa 801841 atgaaaaaat aaacaaagct gccgaactgc tgaaatcaac gaatttgtcg attaaagaaa 801901 tagcggaaga aatcggtttc tcagtacatt atttcactcg cgtcttttcc gctaaaatcg 801961 gcagctctcc agggcttttc cgctcccttt ataaagactc aaaaatgacc gcatttcaaa 802021 tcaataaacc ttttcaaaaa atcgaacagg ccaagccgca cgaataagat gtcctgaaat 802081 gacaaaacaa tgtcttcata tgataaagac gcgagaaatc tcgttgtctt ataatctttt 802141 tagaaagcgg ttacaacaag gggtattgct gaaggaggga tgcattggct tatgcttggt 802201 gtcgggtgct ctgccattct tgaaagaagg ggaagaaagc cgtgagtaca aaaaagaaag 802261 aggctgtaat aggaaaagaa agcttagctc ataaagggct tttacgaacg attacattgg 802321 tatctacatt cggcggcctg ttgttcggtt atgatacggg tgtcattaat ggggcacttc 802381 cttttatggc aactgcaggt cagctgaatc ttacacctgt tacagaagga ctggttgcga 802441 gttccctgct tctcggggca gccttcgggg cgatgtttgg aggacgtctg tccgatcggc 802501 acggccgccg aaaaacgatc ctttatttag ccttactctt catcgcagcc acacttggct 802561 gtaccttttc accaaacgcg tccgtgatga ttgcctttcg ttttctgctt ggactggcgg 802621 ttggctgcgc ttctgtaacg gttccaacct ttttagcgga aatttcgccg gcagaacgca 802681 ggggacgaat cgtgacacaa aatgaactga tgatcgtaat tggccagctt ctggcataca 802741 cctttaacgc cattattggc agcacaatgg gggagagcgc aaatgtatgg cggtatatgc 802801 tggtcatcgc gacacttccg gctgttgtgt tatggttcgg aatgctcatc gtgcctgaaa 802861 gcccgcgctg gctggcagct aaaggcagaa tgggtgacgc cctgcgggtg cttcggcaaa 802921 tccgtgaaga cagtcaggca cagcaggaaa taaaagaaat caaacatgcg attgagggca 802981 cagcaaaaaa ggccggcttt catgattttc aagagccgtg gataaggcgc attctattca 803041 ttgggattgg aatcgccatc gtacagcaaa ttaccggtgt caattcgatt atgtactatg 803101 ggacagaaat tctgagagaa gccggttttc aaacagaagc tgcattaatc ggcaatattg 803161 caaacggtgt tatttcagtt attgcggtca tttttgggat atggcttctc ggcaaagtcc 803221 gtcgccggcc catgctgatc atcggacaga ttggcacgat gacagccctt ctgctgatcg 803281 ggattttatc cattgtcctt gaaggaacac ccgccctgcc gtatgttgtg ctgagtttga 803341 ccattttgtt tcttgcgttt cagcagactg ccatttctac ggtgacgtgg ctgatgctct 803401 cggaaatctt tcctatgcat gtgcgggggc ttggcatggg gatcagcacc ttctgcttgt 803461 ggacagctaa ctttctcatt ggattcacct ttcccatttt gctcaatcat attgggatgt 803521 cggcgacatt ttttatcttt gtcgctatga atatcctagc gattctattt gtgaaaaaat 803581 atgtgcctga gacaaaaggg cggtcacttg aacagcttga gcattccttt cgccagtatg 803641 gccgccgcgc tgatcaggaa atccaaaatc aaacaactca cttatcgtaa cctgagatac 803701 caggaggaat ctatcaatga aactatctta tgtaacagac agcctagggc atttgccttt 803761 tgaagacatg ctcaattttg ccgcaaagct tgggatcgat acacttgaaa tgacaaccgg 803821 gggctggtcg ccggcacctc acttgaatct tgatgaattg ctgcaaagca gcgaaaaaag 803881 aaaagaattt tcacaagcgc tggaaaagcg gaacatgaca ctttgcgcat taaactgctc 803941 ggggaaccct ttagatccgg gtgaattggg caaatcgcac agagacataa ctgacaaaac 804001 gatggagctg gctggattat taggcgtcaa aaaagtgatc atgatgagcg gtttgccagc 804061 cggcggcccg gacgacaaag tgccgaactg gatcacatac acagtaagct ggcctcccgt 804121 tttaaaagat atcctcaact atcaatggga agacgttgcg atcccatatt ggaagaagct 804181 tgtcaaaaaa gcggaggcct gcggcgtggg gaaaatagcg cttgagaact tcagctctca 804241 attagtctat aatcctgaga ctctctttcg gctcagaaat gcagtcggcc cgatggtcgg 804301 tttgaatctt gacccgagcc atttgttatg gatgggcgca gacccgatca tcgcagcaag 804361 ggagctcggc tcagccattc accatgtcca tgggaaagat gtcagaattg aaagatattt 804421 atcggcggtc aacggacttt tagaaacaaa agaagtgaca gatcctgcaa accgggcgtg 804481 gaattacgta gctgtcggct gtggacagga tttacagtgg tggaaggaat ttttttcagt 804541 tgtaaaaatg atgggatatg aaggtgaggt ttctttagaa atggaggatc tgacgatgtc 804601 acctgaagcg ggcatccgta cttctgtaga agctttaaaa caaaccatca gccaatagga 804661 ggttttcatg atgctaaatg gagaaagaat catctctaag ccgcttcgct gggcaatggt 804721 aggcggcggg cggctcagcc aggttggata taaacatcgt attggagcgc tgagagacaa 804781 tactgctttt caattaactg ctggcgcttt tgatatcgat gccgaaagag gaaaagattt 804841 cggggtgaac cttggagtgg atgcggaacg ctgttatccc aactatcaaa ccatgtttgc 804901 cgaggaagcg aaaagacagg atggcataga ggtagtatcg attgccactc cgaacggcac 804961 tcattatgag atttgtaagg cggcgcttga agcaggagtg catgtcatct gtgaaaaacc 805021 gctgttcttc acttcagcag aggggcagga aatcaaagcg ctcgcagaga aaaaagggaa 805081 aattgtcggc gtgacgtacg gtttttcagg caatcaaatg cttcttcaaa tgcgtgcgat 805141 gattgaacaa ggaatgatcg gcgatattcg cgtggttgac ttgcagtaca cacacggttt 805201 ttgtgcaaca gatgaaggtg aaaagataag cgctgcacag aaatggcgtg tcgaccctgc 805261 gatcgccggg ccaagctttg tgctgggcga tttatctacc cacacgtatt atatgtcaca 805321 gcttattatg ccaaagatga aaattaagga gctgctgtgt gaccgacaga gcttcgtcgg 805381 cagccgcgca ccgctagagg ataatgccca tgtgctgatg cattatgaaa atggagcggt 805441 cggaacgatg tggacatcgt caatcaatgc cggatgtatg gatggccata gaatccggat 805501 tgtcggctca aaggcaagca ttgagtggtg ggacagcaag ccaaatgaac tgacgtatga 805561 agtgcaggga gagccgggcc agacactcgt tcgcggcatg ccgtatttag atgatgtttg 805621 caacgccgat gaacgactgg gcgccttaca cagcgaaggg ctgtccgaag catgggccaa 805681 tatttatctt aaatttgcca ttgcgataga cgccaaaaac cgtgaagatg aagaaatctt 805741 gaacaacttg gtttatcctg acattgatgc agggatcgag ggcattcgct ggattgagaa 805801 ctgcgtgcgc tcggcaaacc aagggtcagt ttgggttgaa tttaaataaa tgagggaatg 805861 cgccgcatat gacataaagt tcatatgcgg tttttatttt ccagaaactc ctgtcaaaaa 805921 tgccctgagg caggtatgat aagaagggaa ttgggtatcg ggagtgatga gcgtgaaagc 805981 tctttttttt acgagaatgt tcaccttgat ggtgagctgt ttaatgtatc tgtccattgt 806041 gaaagaggat aactggtttg gatatgtatt tatagcagca ggtgctgcca tgtatgcagc 806101 caatcatgtt ttgctgacaa aagagacaaa tgccatctgg ttctgcctga ttgatattgc 806161 aatcggcttt tcgttcggat ttatctttcc cggcacaggt ttgttcatta ttatgctttg 806221 tccggttgcg gtcgcctttt ttctgcgggg gtttcctaaa agaacagcat ggtctgtctt 806281 atgtctttcc tctattttat ttttgaccgt cctcatccgt acatatgcga tgttcggcaa 806341 tgaatttgtc attgatcatt tgactagcat gacattcgtt gtcttctgcg gtgtcgtggg 806401 caaattaatc cgcaagctgt tggatgcgca ggatacggca aaacagcagt ttcaggaact 806461 gacggagtcc catctggcgc tgtctgctgc acatcaggag ctccatttat atgcgaagca 806521 ggttgaagag ctgactgcca tttacgagcg gaacagaatg gcgcgtgaaa tccatgatac 806581 agtggggcat aaaatgacgg cccttctcgt ccagctgcag cttttgcgtg aatggcaaaa 806641 aagagacagc caaaaagcgg atgagacagt aggtgtctgt gaaacacttg cccgtgaagc 806701 gcttgatgat gtccgcttat cagtacgcac tctgcaaact gaaaacgatc cttcgctaat 806761 cgaatcgctg aaacagctga cagaggactt ttgcaaaaat gcaggagtca caacagaatt 806821 tgcggtcagc ggtgatcctg caatcatccc gctgtctctc catccgaccc tgatcagaac 806881 ggtgcaggaa gcactgacca atgccaaacg gcacggcggc gccgcagcct gttcgataca 806941 gcttgcctgc acaacggaca gcatcagcct tgtcattaag gatgacggca aaggcaatcc 807001 tgaggcagca cttggttttg gtctcttgaa tatgaaaaag cgggcagcgg agcatggcgg 807061 aatgatccgc tttgaaagcg aacgggatca aggatttact gtaaatgcag aattttcact 807121 tgccaataaa aaatggagct tcgggcccgt gcagcaaaag gagagtttat catgattaag 807181 atcatcatta ccgacgatca ggatatcgtc agagaagggc tggcatccct gctccagctc 807241 cgagaagagc tcgatgtgat cgcaacggcg cgaaacggac aggaagcctt cgaaaaggcg 807301 aaagagctgg agccggatat cgtgttaatg gacatccgca tgccggtttc caacggggtg 807361 gagggaacaa aattaatcac aagctcgctg ccaagcgtaa aggttttgat gctgacaacc 807421 tttaaggatt cagcgctgat tgctgaagcg cttgaagagg gagcaagcgg gtatctgctg 807481 aaggatatgt ctgcagatac gattgtaaaa gcagtgatga ctgttcattc tggcggaatg 807541 gtgcttccgc cggaattgac tgcccaaatg ctgaatgaat ggaagcgtga aaaacagctg 807601 aaaggaataa atgagataga aaaacctaac gagctgctcg acctgaccga gcgcgaaatc 807661 gaagttctgg ctgagctggg atacgggctg aataacaaag aaattgccga aaagctttac 807721 attacagaag gcacagtcaa aaaccacgtt tcaaatatta tcagcaagct ggctgtcagg 807781 gacagaaccc aagccgccat ttactcggtc agatatggtg tatctgtctt ttgacatatg 807841 acgttttgca tatacgcttc tctgaaaagg ccttttacag gccttttttt catgccctat 807901 gttctatctg ccgctacatg ccgcacgcct ttctttcttc tacaatggca atggatcaaa 807961 aaaaggagtg agacgacgtg ctgcaagcag aaaacatcaa aaaggcatac ggaaaaaaaa 808021 caatcgtgaa aggcatttct ttttccctca aaaaggggga gtcgttcggt ctgctcgggc 808081 ctaacggtgc ggggaaatcc acaaccatct cgatgatttc cggccttgtg ccgcatgaca 808141 gcgggaacat cacggtgggc ggctatgtta tcggaaaaga aacggccaaa gcgaaacaaa 808201 aaatcggcat tgttccgcag gaaattgcat tatatccgac gctgacggct catgagaatc 808261 ttatgttttg ggggaaaatg tacggactta cgcacggtga ggccaaaaaa agagcggctg 808321 aggtccttga atatgtcggt ctgactgagc gggctaaaga taagattgaa acattttccg 808381 gggggatgaa acgaagaatc aacatcggtg cggctttaat gcataagccc gagctgctga 808441 ttatggatga accgactgtc ggtattgacc ctcaatcgag aaatcacatt ttagaaacgg 808501 tcaaacagct caacgaaacg ggcatgacgg tgatctatac gagtcattac atggaagaag 808561 ttgagttttt atgcgaccgg atcgggataa ttgatcaggg ggaaatgatt gcgattggca 808621 caaaaactga tttgtgcagc cgccttgggg gcgataccat cattcagctc acggtcagcg 808681 ggatcaatga agcgtttctt gtggcgatcc gatctctggc ccatgtgaat gatgtaacag 808741 tacatgaatt agagctcaaa attgacattt ctgcggctca tcatgagaaa gtcgtcacaa 808801 gcctgcttgc tgaagccact gctcatcata taaacctgct gtctcttcag gtgcaggaac 808861 cgaatctgga gcgcctgttt ctgaatctga ccggccgcac gttgcgggat tgaggaggga 808921 cggcaatgaa aaaaagcata tggatcgcat ggaaagatgt gaaaatcaga atcacggaca 808981 gaaaagggtt tatgatgctt atcctaatgc cgctcatcct aacctgtatt ttaggcgcag 809041 cgctcggatc agttgttgac ggaggcagcc ggattgatga tatcaaagtc ggctacattc 809101 aatcagacca gtcagataca gcaaacatgt ttacaaaaga tgttctcaaa aaaatgaagt 809161 cgataaaggt cacaaaagtc ggcagcaaag acaagatgaa aaaactgatt gatgaaaaga 809221 aaatcgatgt aggcatcgtt atcccgaacc attgggaagc cggcaaaacc tcagctgttg 809281 ttaatgccgc tcctgatcaa acattgaaaa gttccatcat tgaaacagct gcaagctcat 809341 ttatagagca atataaagcg gtaaaggaag ccgcgtcagg ctcaatggac tacatcagta 809401 aaacggaagc tgtaaagcaa ggaaaacttg accctgcaca gtttgcagaa aagctggcaa 809461 agacgctaga aaaagaaaca ggtgacaagc ttactattgc ggaaaaatct gtcggcagca 809521 aagccgttac cagttttcaa tactattcgg cggcaatgct ttgcatgttt atgctgtttc 809581 atatcacagt cggggcgaaa tcatttttac aggaaaagga tacggagacg cttgccagaa 809641 tgctgatgac gcctgcgcaa aaatccgtca ttctcttcgg aaaatggctt gggacgtatc 809701 tgtttgccat catacaattt ttcatatttc tgatcgtcac aatcaacgta tttggtgtgg 809761 actggggcgg taatctgctg ttagtgagtg tactcgggct ttcttacgcc gcagctgtat 809821 ctggtatttc aatgctgctt gcgtcgtgca tcagcgatat gaaaactgca gatgcgatag 809881 gcggcttcgg cattcaattg cttgcggttc tcggcgggtc catgctgccg ctgtaccaat 809941 ttccggacgt cttgcagtct gtatccaaag cggtgccaaa tcgctgggcg cttgacggct 810001 ttctttcttt aatggaaggg ggaggctggg ctgaccttca aaagcctgtg cttctttttg 810061 cggcgatcgg cttttgttca cttgtaattg gtatcagacg gcttcataca agataaggag 810121 gtacaaaagg tgaaaaaaat tctagccatt tgcggcattg agctttctct catttttaag 810181 aagccacaga actatttgat catgtttgct gccccgcttt tgcttacctt tgtatttggg 810241 agtatgctca gcggcaatga tgataaggtg cggcttgcaa tcgttgatca ggacgatacg 810301 attctctcac agcattatat tcggcagctg aaggcacacg atgatatgta tgtattcgaa 810361 aacatgtctg aaagcaaagc gtcagaaaag ctgaaacaaa agaaaattgc cgggatcatc 810421 gtcatttccc gctcgttcca gacacagctg gaaaaaggca aacatcctga gctgattttc 810481 cgtcacggcc ctgagctgtc ggaagcgccg atggtcaaac aatatgcaga aagcgcattg 810541 gcaacgctca atattcaggt gaccgcggca aaaacggcat ctcagacagc gggagagaac 810601 tggaaggcgg cgtataaaac ggttttcgcc aaaaaacatg aagatatagt tccggctgta 810661 acacgacaga cgctcagtga taaaaaagag ggtgcggaag caagtgacac agcctccaga 810721 gcagcagggt tttccatcct gtttgtcatg ctgaccatga tgggagcggc tggaaccatt 810781 ttagaagcaa gaaaaaacgg cgtatggtcc agattgctta cagcctctgt cagccgagcc 810841 gaaatcggtg ctgggtatgt gctgtccttc tttgtcattg gctggattca atttggaata 810901 ttgcttcttt ccacccattg gctgtttggc atcaactggg ggaatccggc tgcagttatt 810961 gtattagtgt cactttttct attgaccgtt gtcggcattg gattgatgat tgcggccaac 811021 gtcagaacgc cagaacagca gcttgcgttc ggcaacttgt ttgtcatcgc aacatgtatg 811081 gtgagcggga tgtattggcc gatcgacatt gaaccgaaat ttatgcaatc catcgctgaa 811141 tttcttccgc aaaagtgggc gatgagcggg ttgacagaga ttatcgctaa cggtgcccgc 811201 gtcacagata ttctcggaat ctgcggcatt ttgcttgcat ttgctgcgat cactttcgca 811261 gcggggctga aagcgctccg agcctaaaaa acatctgccg tttaggcaga tgtttttttg 811321 catgtgggta cattcgtatg ggtgcagcct gaactgcggt taatccttat ctatcatagc 811381 taaaattgat tccagccaag aaacgtaatt tttctcccgc tccagcgctt tcgttagcac 811441 aagatagtgg ccgaagtccg gtgaagaaaa tgacatcggc tctgctgaag ccataagctt 811501 ttcatagctt ccctgtaagt cagaaagctt ggcctggcgt ttttgcagct ggtctttgaa 811561 caaatcagaa gcctcctggc gcgatagaca agaaatgaaa taagccttca gcataaattc 811621 atccttcacc gtctcgggta tcggctggtg gcggatcagc cagtcatgca gctcctgctt 811681 tccgctgtct gtcagggtgt acatcttttt ctccagcttt gtgccctgaa tcgttgtccg 811741 gaacgtgata aatccttcat ccgtcagctt tttgagctca gggtaaatct ggctgtgctt 811801 ggcgctccaa aactggccga gctcctcttt aaaataactc gtaatatcgt atccactcaa 811861 ttcgcctttt cgcaaaagcc ctaatatggc gtattttaat actctcatgc tatcctccgt 811921 gtctggctgt ttcgcaaaac agatgagccg gtgctcaact gtgattctaa ctgcctattc 811981 cccttattat agaaaaggga ggaagggaac acaaccgggc tctttggaaa tgaagataaa 812041 aggtttgtca gaaggtatcc gatttatctc cgtcaatata aaagagattt aaatttaatt 812101 ttcagaaaaa atagtaacga tattgatttt ttatatataa taggaaattg gtggtatgaa 812161 aattttttgg gggaataaac gtgaaaaaag tacttatggc attcattatt tgtttatcgc 812221 tgattctatc tgttttagcc gctccgccgt ctggcgcaaa agctgagtca gtacataatc 812281 ctgtcgttct tgttcatgga ataagtggtg catcatacaa ctttttcgct attaaaaact 812341 acttaatttc tcaaggctgg caaagcaaca aactgtacgc aattgatttt tatgataaaa 812401 caggaaacaa cctaaataac ggcccgcagc ttgcttcata tgttgaccgt gttttaaaag 812461 agactggggc aaaaaaagta gatattgtgg ctcatagtat gggaggcgcc aatacgctgt 812521 actatattaa atatttaggc gggggcaata agattcaaaa tgtcgtaacg cttggagggg 812581 ctaatggttt agtgtcatca accgcgctgc cgggcacaga ccctaatcaa aagatcctct 812641 atacatctat ttacagtctc aatgatcaaa ttgtcatcaa tagcttgtct cggttacaag 812701 gagcgcgaaa catccagctt tatggcatcg gtcatattgg cttgctttct aatagccaag 812761 tgaacggcta tatcaaagaa gggctgaatg gcggaggcct caatacaaat taatatcttc 812821 aaaaaacaac ctgctgtctc cgttacagtg ggttttttcg tctgagaaag ccatagggtc 812881 ttatgacctt agtctatcat gcatacgtca atttatgaca tcaggcactt tttcaaatag 812941 agcggacatg ttaaggtaca accatcgatt tctatcaatt tgaaataaaa ggagcgctgt 813001 tatgcaaatt aaagaaattt ttatgatccg ctgcatttcg tgcttaagtg tcgtcttgct 813061 ccatatcatt tcaatggtcc tgatgcttca ggcagaagct cttgcagata tttctcacac 813121 tgttgattct ttccgcacac tcctgatgtt cagcacgccc gcttttattt tcatctctga 813181 atttttactg gcccgttctt atcctgatgg ggtgcctgac ggttttttaa agaagcgggg 813241 aaaagtgatt tttgttcctt ttttatttat cgcagccatc gatgcgctgc tgatgaccag 813301 tgcgatgggg ggagaggtaa cctttctcgc gtttgtgcaa aaatatctgg cgaacgtatt 813361 cttaggaaac tttatcggat acttcattct cgtcatcttt caattttaca tgctgcatat 813421 gatgtttcat gagtatttga aaaaagcatc gccgaaatgg gtgctgtcta tctcatttgt 813481 ggtgacagcc gcttatttag gctatttctc cgcagccagc ccggctcctg cttctgaaga 813541 gggaggggca tttccgttct tctgggttcc gttcgcaggc tggcttttct acttttgtct 813601 agcctactat tgcggaaaag aatacaagcg ttttttagcg ctgctgaacc aataccgctg 813661 ggtggtgtac ggcgccgcaa ttgcttctgg ggcgctggtt gtcactgttt cttatgtcgg 813721 tgaaatcggc atgatcagct cgaagcggcc tgatatcatg ctgtattcaa caagcatgat 813781 tttcctgtgt tttcatttgt tttccaaaat gaagcatgtg ccgaaaatca tgatgtttat 813841 cagcaactat tccttttcga tttatctgct tcatgcctat tttatgatta taggctacgt 813901 gttgcttttg aatatgcccg aaattcctgc cgtaccggct gttctcctgt tgtttgccgt 813961 gtgcacagcc ggcccgatta tgacctcatg ggcgctgaat aagttcaaat acgggtattt 814021 atttgtgggg aaaatttatc agccaaaaca gaagaaggta acagtcgaag tgcgtgatca 814081 cgcagggtga aaaacaagcg gcaggagggc tcctgccgcg tttctttact tctcatccgc 814141 ttgcagaact gtttttaaat atagttttgc agactcagca agtccagata catcagcctt 814201 ttcttcatcg aaatacaggg cgttttgaat gatgccgtca ttcatattga ggaaaaactt 814261 ggcgatagtc gcaagaggct gaaccggctg aaactctccc tgatcgatcc ctttttgcaa 814321 tagccttgaa aacctttcca caaaaagatc ataccttttc tccaaatact gccgccgttc 814381 ttcattgcgc caagctgtca ctaaatattc aaattgcacc ggcgccagcg tatctgctac 814441 atctcgcagg ccctcagtca gttcatccaa atagctggaa atggaggccc aaacactttg 814501 gtgttcagct gatttatcaa gctttcggag tccttcatcc agccctgttt caataatgcg 814561 gcgaaacatc tcctcagtgc ttgaaaaata aagatagaca ccgccccggc tgaaacctga 814621 ctcttctaca acatccttca tcgtcgttaa ttcgaatcct tttcgtttaa aaaccgtttt 814681 ggcagcctct aaaatctctg cctgccgttt atccttgtgc tcctttgtta cttttggtga 814741 caagatatcg cctgctttct gcaattttct tacctataag tgtaatcaac ccaatcatga 814801 tcagcaagca gccacagaca agaaaagcaa gtgatacacc gatccattcc gccagcacgc 814861 ccccgcccgc catgccgagg atagaggcga gggttgtcgc actctgaata gcgccgaaca 814921 ccctaccgct gtaatcgaca ggcactgttg tttgcacgag aatctgaaat ggaatatgga 814981 cgaggccgaa agccgccccc atgatgaaaa aagcaaatat aaagagagtg atgccggcaa 815041 ttcccatacc gcttaggaat ggcgcacctc cagttgctag tccaagaaga agggttccag 815101 ctgagaaata aagcaaataa gaagtgattc gccgtctgcc ggtaatggcc gctgtaagga 815161 gcatcccggc tccgcttacg gccatgcacc agcctgccag ctcgggcgga gctcctgaaa 815221 aggagcggat aagaataatc gcttgggaat caccaatctg caaaacaaag agaacgacac 815281 aagctgttag taagcctgtt aatagaagcg gcatccgttt caaaaactga aggccttcct 815341 tgatagaagt aagtgctgct gttttttctt gaggtgtatt ggctttttgt aaaaaagcat 815401 ctctgggaag gaaaaacaaa atgacagcgg aaagaaagaa ggcgccggcg tttatataaa 815461 aaacagagtg tatcgagaaa gcagcgatca gcgtgccgcc aagggcaggg ccgaagattt 815521 ttgagctgtt atcaatgatg ctgctgacgg aaacggcctg ctgaatgtgt gcttccggag 815581 ccaattcctt aagctttccg tttttagcag gtaaaaaaag tgaagaaaaa cagctctgaa 815641 cggatagcaa tacgtaaagc tgccaaagct cactgacata aacgcagctg ataacagtga 815701 gggcacggcc gatttcagat agaaacatga tcgtttttct gtcaaaacgg tcggcaagca 815761 gacccgatac aggtccgagt acaatgacag gcaaagcaaa cgacatcatt aaaagcgaca 815821 tatctaatgg agaagcatga agctgaaaag cggctaatgt tagcacggcc aaaatgtgaa 815881 gccagtctcc aagtgaagaa atggtttgcg aggctaacag tgtcatcagt cctttttgat 815941 tgcgaaacaa cggtttttcc atgattcatc ctcctgatta ttaaaatgac actagtgtcg 816001 tttttaattg tatgggaaaa agacacaata tacaatcttt ttcttgtaaa ataaaggaga 816061 agattgaata gaagggagaa cattcatgac atcagtcaat ctaagctacc caataggaga 816121 atacaagccg agggaatcca tatcgaagga gcaaaaagat aaatggattc aagtacttga 816181 agaagtgccg gcaaaattga agcaagctgt agaggtcatg acggacagcc agcttgacac 816241 accgtaccgg gacggtggat ggaccgttcg gcaagttgtt catcatctgg ctgacagtca 816301 tatgaacagc tatattcgtt ttaaattgag cttgacggaa gagacaccgg ctatccgtcc 816361 gtatgatgaa aaagcatggt cggagctaaa agactcgaaa acggcagatc cgagcggctc 816421 actcgcgctt ttgcaggagc ttcacggaag atggacggct ctgctccgca ccctgacgga 816481 tcagcaattt aagcgcggat tttatcaccc tgatacaaag gagatcatta ccctggagaa 816541 cgcgctcggc ctgtatgtct ggcactcaca tcaccatatc gctcatatta cggagctttc 816601 cagacggatg gggtggtctt aacgcttttg ccggcggaaa gccggaatac tgatagcagc 816661 aatcaccaga agtgagacca cagcagccgc tgcatataaa tgatcatagc cgctggcgac 816721 actcgcatga atggcgtcgc ttatcgcggt tttgacttca ggaacgggaa tgcgttcgat 816781 ttgttcttgt aaagaagaaa cttcagaact gtcgatctcc ggaatcatct gcatcgcctt 816841 ttctgaatat ccgctgtccg ataagcggct gttgatctca tcacctattt ggtcaaaccc 816901 ggctgtgata aaacctgcat aaagagtagg cgccaaggtc agtccaattt gccttactaa 816961 tgaaagcgtg ccaagagctg tacccttatt tgtttttgcc gcttctgata caaggacgtt 817021 cagcggagcg cctaacagaa agccaaaacc gatcccagct gccacacttg cgatcacaaa 817081 ctcccatttt tccgtgaccc agagcggaaa taaagcaaac cccgcacatg agatgattcc 817141 cgaaagaata acggttttta caggaccttt tttgtcggta agtgctccgc caagccaagc 817201 gccgattccg gaagccaacg caagcggtgt catccaatag cctgcttttg cggcagggac 817261 acccaaatac tgttcgacat atgacgggat aaaaatgact gccgccaaga gccccccgga 817321 taacaaaccg atgataagcg tgcgctgaaa catatggttt cgcagcagag aatacgccaa 817381 aatgggatcg cctcctcgca tttcaactct cttttcatac gagataagcg ctgcaaaaca 817441 gagtatgcca aaaataatac atccataaac ctccggattc cccaagctgt gtaagagatt 817501 tgccccgtca agattggtca tgccgtacat cacagctaaa atcgacaggg acaaaaggaa 817561 gattccggcc gcatcgaggc gcttagcctc aggtgctttt gtttccgcga taaaacatgc 817621 gccgaaaaca accaatagca cggcaatcgg caaattaatc aaaaatagcc aatgccaaga 817681 cccggtccaa tcaagcagaa agcttccgat atttggcccg agcacagcgg ccatcccgtt 817741 cattgcgcca agcagcccaa gcgccttccc ctgtttttcc tttggaaggg tcgcgagaat 817801 gtgagagctg ccgatgatga aaatcccgcc gcctccaagc gcctgaatca gccgcgatat 817861 cagaaagagc gggaagcttt ggctcaaagc aacaagcaaa gaaccaagtc cgaacaggca 817921 aacctcaatg agaaagagtt tttttctgcc gtagcggtcg gaaagttttc cgacgattgg 817981 cacactgacg ctaagaccga gcgtataaag ggtaatgccc catgatcccc aggaagggga 818041 aacggaaaac gactcgttta tcgttgttaa agcagccgaa ataattccgt tatctaaagc 818101 agccataaac acgccaatcg taaacaggct gattgcccac ttttggcttt tctgctctgt 818161 taatgcttca gacattttcg tcaactcctt ttagttcact tgaaatatat tattcatttt 818221 aaatgaacta aatgtcaaat aaaaaaagcc tgctcccgca gtttgcggat gacagactta 818281 ctgatttatt cttttttcgc attctctaat gctcttgaaa ggatagacag cccttcgtaa 818341 acagcctgct tttcttcagg ggacagcagc tctaatgaac gcttcaattt caggtggccc 818401 ttttcataca aaccccggaa aatctttttc gcattctctg tcaactgaac aactacagag 818461 cggcggtcct cttcagaatg tgagcgtttg acaaatcctg atttttcaag ccggtcaagc 818521 agcccagttg tattggacag ggaagccccc attttttcag caatgtcgct cactttcaat 818581 gttccatggt tgtttaatag catcagcacc ttcatttgcg gcatgctcat atccagtttc 818641 atccactcgg acacatcacc gagcccggcg gacgttaaga ctttcatata gagcacccat 818701 atttcccgtt cctccgatga aagaatgttt tcgtttaaga ctgttgtatc gtgtaaatta 818761 tattccattt catcacttcc tcatcattca ctcctcttac catattactc gattttcact 818821 cctgaaagaa agtgagcaga aaccgcatgc gggactttgt ccgaaaaata acggtagtgt 818881 ataatgagtt ggagattatt gggggagagg atcgaactag aatatgattg gagagaccat 818941 tgctgattaa aaagaatgct ttatcaatat taaaaatcgt ttttcctatt gctgttttgc 819001 tatttgttat ttatcaatcg aaaaaagaac tgacaaatct gtcattcaaa cgtacgctca 819061 tggtcatcaa cggactggaa cgaacggatt tattcatgct tgtgttgatc ggcttgctgg 819121 ctgttgcggc tatgtcgctg tatgattacg tcctgaagta ctcactgcgc ctatcgatca 819181 caaacggaaa agttttcagg gtttcctgga tcgccaattc atttaataat gtgttgggat 819241 tcggcggttt agccggagtc gggttaagaa tgatgttcta taaggagcat acgaaagacc 819301 ataaggcact cgtgaaagga atcgcctggc tcacatcatc tatgctgctc ggattatctg 819361 ttttcagcat tttcgttgct gcgagagtgc tgccagttga tgaagtgatt catgagaagc 819421 cttggctgtg ggcggtcgtt atcggttttg cactgatatt gccgttatct ttagcggtgt 819481 ccaaaataaa agaccgcaaa gctggggacg aagagaatgc ggataaagtg aaaaatccga 819541 ttttcgcata tattggagct tcagttgttg aatggctcat ggccgggacc gtcatctatt 819601 ttgctttgtt cgctatgggc attcatgcag atatcaggta tgtgttcggg gtgttcgtca 819661 ttgcggcgat cggaggaatg atcagcctcg tgccgggcgg cttcggctcg tttgaccttt 819721 tatttttgct ggggatggag cagcttggct atcatcaaga ggccatcgtt acttctattg 819781 tgttgtacag gctcgcctac tcatttatcc catttatctt gggactgttc tttgccgccg 819841 gcgacctgac ggaaaataca atgaagcggc tcgaaacgaa cccgcgcatc gcaccggcaa 819901 ttgagacgac aaacgttctg cttgttgttc agcgtgcggt attagtgaga attttgcaag 819961 gctcgctttc ccttattgtg ttcgtagcag gtctgattgt cttggcctca gtttccttgc 820021 cgattgacag gctgacggtt ataccgcaca ttccgcgccc ggcgcttttg ctgttcaacg 820081 gcctgtcctt aagctcagcg ctcattctgc tcattttgcc gatcgagctt tataaacgga 820141 caaaacgttc ctacacgatg gccattacag cgcttgtcgg cggctttgtg ttcagctttt 820201 taaaagggct taacatcagc gcgatattcg tactgccgat gattatcgta ttgcttgtgc 820261 tattgaaaaa acaatttgtc cgcgaacagg catcctatac actgggacaa ttgatattcg 820321 ctgtggcgct gtttactgtg gcgctcttta actacaatct gatcgcgggc tttatttggg 820381 accggatgaa gaaggtgctg cgtcacgaat atttcgtcca cagcacctcg catattacac 820441 atgcaaccat catggcgatc atcattgtgc cgctgttctt cttgatattt acagtggtct 820501 atcataagag aacgaaaccg atcggagaga aagctgaccc tgagcgtctt gctgcgtttc 820561 tcaatgaaaa aggcggcaac gcgctgagcc atcttggttt tcttggagat aagcggtttt 820621 atttttctag cgatggaaat gcactgcttc tgtttgggaa aatcgccaga aggctggtcg 820681 tgctcggcga tccatctggc caaagagaat cattcccgct cgtgctggaa gaatttctga 820741 acgaagcgca tcagaaggga ttcagtgttt tgttctatca aattgaacga gaggacatgg 820801 cgctgtatca cgattttggc tacaacttct ttaaattggg tgaggaagca tatgtagatt 820861 taaatacatt taccttgact gggaagaaaa aagccggcct tcgggcaatc aataaccgct 820921 ttgagcggga ggagtatact ttccatgtgg atcatccccc attttctgat gcgtttttgg 820981 aggagctgaa gcaaatctca gacgaatggc tcggctcgaa aaaagagaag ggattctcgc 821041 tcggattttt tgatccttcc tatttacaga aagcgccgat cgcctatatg aaaaatgcag 821101 aaggagagat cgttgcattc gcaaatgtca tgccgatgta ccaggaagga gagatatcgg 821161 tcgatctgat gcgctatcgc ggcgacgctc caaatggcat tatggacgca ttgtttatcc 821221 gtatgttttt atgggcaaag gaagagggct gtacgtcatt taatatgggg atggcaccct 821281 tggccaatgt cggcactgcc tttacatcct tctggtccga aaggtttgcc gctgtcattt 821341 ttaataatgt cagatacatg tacagtttca gcggcctaag agcctttaaa gaaaaatata 821401 aaccggagtg gcgagggaaa tacttagcgt atcggaaaaa cagatctctt tctgtcacca 821461 tgttcctcgt tacacgtctg attggcaaaa gcaaaaaaga ctccgtctaa taagacggag 821521 tcttttttta tttcgttttt aagaagtagg tttcaatatc atcaagcagg tagtttgcgg 821581 ctttaattcc gcctgcggtt gtccatacga cgtcatcgac ttcatgtgca ttacctgact 821641 tcacggcctt caggtttttc catagtgaac tgcttgtcca ctgattggcc catttttcat 821701 tttcttttgc attatcggct ttataagtga aataaaacag cacatcagca tccatatcag 821761 gaatagattc tttactgtcg gttgagaacg taaattggtc cttttgtttc ttaaacagtt 821821 ccacttgttt ttcagggcgt ttgaagccaa gctggtctaa aataatccca ggaaatgaat 821881 cggtataata gattcttgat tcaccggata aaaagcgtac gactgaaacg gttttgtttg 821941 tctggtcgcc cagcttgttt tttaaatcag aaacacgttt atcaaaatcg gcaatgactt 822001 ccttgccttt gtccgcctta ttcaccgcgt tggcgtatag agtcaggtta tccttccagt 822061 tcccggccaa agattcagca aaaacagtcg gcgcaatcgc atttaactga tcataaattt 822121 tttcctggcg cactttgttt ccaataatca aatcaggctt taattctgcg atggcttcca 822181 cattcggttc cgtttcaaga ccgacgtttt taacaccttt catgtcatct ttcagatagt 822241 cataccacgg gtcgcccttc catgacttta cggctccgac cggcttaatg ccaagcgcta 822301 agagcgcctc tgttccttca ttagttaaaa caacaatccg ttttggattg gcggggatgt 822361 tgtctgatgt ccccattgca tgtttgaccg ttcttgtttt gctgcttgac acctcgctgt 822421 tgcttgaact ttctgaacta ttacaggcag aaagtaccat aacggccatt aaaaatacga 822481 atagcatgct gatatgcttt ttcatctttt tcctcccaat attgaaattc attatcattt 822541 agatcataat aagcagtgtt aagagtgtca atccctaatt gaggattatt ctcaaaaaca 822601 aacattacat agtaaataac taggagaatt agatcatgat ctgcaaaaag gcatcttcaa 822661 aatggattgt gttagtatgt ctgattttca ttttactgac ggctgtctgc gcaagcgtcg 822721 tgtatggcta tacaggtacg tcatggagac aggtctatca ggcgtttact tccttcaatg 822781 gaacaaatga gcatgtcatc atcaaggatg tcaggcttcc gcgcgctttg gttgcgacag 822841 tcgtcggcgc ctcgcttgca gccgcgggcg ctctcatgca ggcgctcaca aaaaatccgc 822901 ttgcgtcacc ggggattttc gggattaacg ccggtgcagg tttttttatt gttgccggat 822961 cgttttttct gcatattcag tcacctcagg cattagtatg gagctcgttt ctgggggcag 823021 catttaccgc tgcgatcgtc tatgcagcag gctcgcttgg gagggaaggg ctgacgccaa 823081 tcaaactgac gctggcggga gctgccatgg cagccatgtt ttcttctctg acacagggct 823141 tgctgtctgt caacgaactc gagcttgccc aggtgctttt ttggctgact ggctctgtgc 823201 agggccggag tctggatctg ttgatgacga tgtttccata tgcagcggca gcgctggtaa 823261 tctgcttctt tctcggccaa aaaattaatc tcctcgttat gggagaagat gtggcaaaag 823321 gactcggcca aaaaacaggc ctgctgaaat ttgtgatggc gctttgtgtt gtcatgcttg 823381 cagggtccgc tgtcgccatt gccgggccga tttcttttat cggcatcatt attccgcatt 823441 ttgcccgctt tgtcgttggt aatgattatc gctgggttct gccattttcc gctgttttgg 823501 gtgccatttt gcttgtttgc gcggatatcg gtgcgcgata tatcattatg cctcaggaag 823561 ttcctgtcgg ggtcatgacc gccatcatcg gaatgcctgt gtttgtgtac atcgcaagaa 823621 ggggggcgaa gctatgaaac ttcgttttgg cgttactgcg gctgaaaaga aagcatggat 823681 cgtctttttg gttttactgg ggttaacagc tgctgtactc atcataagcg ctggtctcgg 823741 acaaaggttt attcctccct gggatgtagc aaaaacattc tttggtgcag gttccaagct 823801 ggatgaactg atgatcatgt cgttccgcat gccaagaatt ttgacggctt tatgcgccgg 823861 tgtctgcttg gcagcggcag gcgcgatatt gcaggggctc gtcagaaacc ctctcgcatc 823921 tccggatatt atcggaataa caggaggagc ggcggtagcg gtcgtgcttt taatgatgtt 823981 cttctcagac cgcagcagtt cacttacgat cagtctgtca tggcttccag cagccgcatt 824041 tatcggcgca tcggctgtcg ggctcatcgt ctatttactg gcatacaaaa atggcgcctc 824101 cacatttcgg ctggtgctta tcggaatcgg attttcaatg tcggcgcagg cgatgactac 824161 cctgttgatg atcaaaggcc cgatttaccg agcatcacaa gccaatgtgt atatcactgg 824221 gtcagtttat gggtcaaact ggcagcatgt aaaaatagct attatcttat ctgtcattct 824281 cttattcatt tgttttgtcg cgctaaaaaa tatgaatata caggtgctgg gtgaagatat 824341 tgcggcgggt gcaggaagcg ctgtgcagcg aaatcgtttt ttcttgctcc ttttgagtac 824401 ggctcttact ggttgtgcag tttcagttgc cggcacaatc ggttttgtcg ggctgatggc 824461 gccccatatt gcaagacggc ttgtcggctc atcttatggc gcgctgctcc cagcgtcggc 824521 acttattgga gctctgctcg ttttaacagc tgatatcgtc ggcagaacct tatttgctcc 824581 ggtggaagtg ccggccggcg tctttacagc ggctatcggc gcaccttatt ttatttattt 824641 gctctataaa acaagaaatt cttaatcgtt acacccattt tcttaaaaaa gaaaatgggt 824701 ttttttgata atgactgaag attcgtaatt atttttgcta tactgacaga gacattgata 824761 aagaaagggc ggcagatgaa tgaaagaagc agaggtatta aaatatgaag catttacaag 824821 cagtcccggc aaaggaaacc ccgcaggcgt cgttttgcag ggagacgatt atacggaaga 824881 cgagatgcag atcatagctg aacgtgccgg gtattcagaa acctccttta tccgaaaaag 824941 cgagtcggcc gatcttgaac tccgttactt tacccctgga cacgaaatga atttgtgcgg 825001 tcatgcgaca gttgcttctc tttacgcatt atgtgagaaa ggaatgctgg agagcggtaa 825061 aacgtacagc atccaaacga aagcgggtat cctgcctgtg aagatttctg aaaaagatgg 825121 ccgcattcat atcacgcttg aacaggcctc tccgcaattc aaaccattta caggcgatcg 825181 gaaaaaactt gcggacgcac tgggtatcac cgatgaagat tttcatgaag accttccgat 825241 tgtgtttggc agcactggga tatggacagc catcgttccg cttaaatcat tggaggcttc 825301 caaaaaaatg gtgccagata acaaacaatt tccggaagtg ttagttgatc tgccaaaagc 825361 ttcagtccat ccgtttacct ttgaaaccgt ccatcccgac agcgacctgc acgggcgcca 825421 cttttcatcc ccgtattcgg gaacgattga agaccccgtg accggcacag catccggcgt 825481 gatgggggct tatatgaaac attatggcaa tgccgagcag cataaattta tcattgaaca 825541 agggcaggaa attggaaaag acggaaaagt ggagatcgaa atgaacgaag ccggcggcca 825601 tgtgaaagtg aacatgacag gaacagccgt ttactcagaa acccgtattc ttaaaatcta 825661 atacggatga tggtttacaa aaagatgcac tttccgttat cattatgaaa tgataatcat 825721 tttcaattgc ataggaaggt gagacggtat gcctcaaacc gaacaaatac atcagcattc 825781 agtactgagg gacatcatac gcagcagaag atcgattcga aagtttaaac aagagccagt 825841 accttcagca gtcattcttg acatgcttga aacggcaaaa tatgcgccaa atcacagagt 825901 gacagagcca tggagattta tttacgtttc cagtgagaca ggtaaagcga acctcattaa 825961 tacatttgca gcgttctcta agaaatccaa gccggatatg acagaggaaa agcttcaaaa 826021 tttcaaaaac acacttgggc gcgttccggg atttctcctc gtcgtgtttc aggaagatga 826081 aaacgaaaga gcgcgggacg acgattttgc ggcaacaagc tcgttgattc aaaatcttca 826141 gcttctcgct tgggaaaaag gaatcggcat ggtttggaaa agcggaaaaa tcctttatga 826201 caaagaagtc catcaggcct ttggtttaca ggataatgag cgtttcgccg ccatcataca 826261 aacaggttat cctgacgagg cgccggaagt gaaaaaacgc acaccgatcc gcgaccgatt 826321 cactgaaatg taaaaaaccc cttgtctcaa acggagacaa ggggtttttc attaacgaga 826381 tttctttttc gctctgttgt cggctgcttt cgcacgctct tgcgcttcgc ggtcatctgc 826441 atcagcaagc tcggttgaat attcttcgta aacgccgtca gtttcccttt ttaaggcatc 826501 gggaacttgt ggaagctttt gtttgttttt atcacggttt ttgtggatat gatttctgcc 826561 catatcaaat tccccctaaa aagtgatatc aaacaaatat agtatttggt tttaaggggc 826621 tatgtattcc tacttccgct tagcagcttt ttccgctttt ttaaattcgc ctgaataaag 826681 aacttcctgc atttttttca ggttggcgcc ttgctggtgc ttctccctct ttttttccat 826741 aaaaaggacc tccttcaacc atgttattct taaggttgac gcttcctgct gtttttatac 826801 agtctttcgg tccgctatca gctgtgagag tgcaaattca agatccgaat atgtaaaacg 826861 aaatccagag gttatcgctt ttttcggaag agcgcgctgt cctttcacaa tcaaaagact 826921 catttcaccc aatgcttttg ataaaaagaa ttccgggacg gggagccagt gcgggcggtg 826981 cttcacccgt gcaatcgttt ttccgaattg cttcatgtcc acaggattgg gcgcggtgac 827041 attcattggg cctgagatgc cggcgttttc caccgcatat cggatcatct gggccgcatc 827101 ctcgacatga atccatgaca gccactgcct tcccgttccg atcgttccgc cggccagaaa 827161 cttatagggg agaatcatga gcgggagagc gcctttttct ccaagcatca cgccaaatct 827221 cgcataaact gtccggatgc ccatcgcttc aatatgctgt ccttcctttt cccacaggtg 827281 tgcagtatgg ctgagaaaat cctcatctga cgttgcagaa tcctctgtga aagttttctc 827341 aaggcttgtg ccgtaaatgc ccacggcact ggcttggatc aatgtcttcg gcttctcctt 827401 ctgtttctga ataagccgct gcacttcacg cgtcgcattg atacggctgg agagaatgtg 827461 ctgcttcgtt ttttctgtcc agcggccaaa aatcgatttt cccgcaagat ttatccagac 827521 atcaatatga ggaagttcct gctccggtgc ggctccttcc gacagccatt ggacatatgt 827581 catatttttt tgttcagttt cccttgcgtt tcttgataaa atataaacat ggtgtccctg 827641 gcgggtaaga acgcctgtca gatgctggcc gagaaaaccg gttccgcccg tcattgcgat 827701 attcatgaac atctctcctc atcgttctaa taaatatact ttacctcatt gtaataaaag 827761 aaaacgcgtt tcaggcctga gaagggagat taagatgccg tttattacaa aaatatcaac 827821 gcaaaaaaag aatacggaac gcttcaatat ttttctggat gataaatacg ccttcagcgt 827881 ggacgcggat gtgctcgtga aatttgagct caagaaggga aaagaactcg atgatcttga 827941 catcattgag attcaatacg gcgatgaagt gaagaaaggc ttcaaccgtg cgcttgactt 828001 tttatcctat cgaatgcggt cgacgaaaga ggtcgaggat cacttaaaga aaaaagaaac 828061 ctcgcccccc gtcattgcgg aagtcatcca taggcttaac gattacaagt acttaaacga 828121 ccaggaattt gccgcagcct atgtcagcac tcacaaaaaa acaaacggaa aaggccctga 828181 tgttttgttc agagagctaa gagcgaaggg aattgatgac gatacaatta aggaggcgct 828241 aagttccttt tcctttgaag atcagacaag agaagcggtc aagcatgttg aaaagcttct 828301 caaaaaagat aaaaagcttt cgacgaaaga actcaaacag cgcgcccagc tgcagcttca 828361 gcgcaagggc ttctcatttg atgttatcag cgcggcgatg gatcagattg aatatgaaaa 828421 tgatgaagac acagagaaag aagcgctgcg ccttcacgcg gaaaaagcgt ttagaaaata 828481 ccgctatgac ggctcatatg aaagcgccat gaaggtcaaa caatttttat tccgcaaagg 828541 attctcactc gatttaatcg agcaattact gcaggaagag gagtactgaa atggagaaac 828601 gatacagtca aatgacaccg catgaactca ataccgaaat cgcattactt tctgaaaaag 828661 caagaaaagc cgaacagcat ggaatcataa acgaactggc agtgctcgaa cggaaaatta 828721 cgatggcaaa agcatatttg ctgaacccgg aagattactc accgggagaa acatatcgtg 828781 tggaaaacac tgaggacgag tttaccatca gttatttaaa tggcgttttc gcatggggat 828841 acaggacctc ttcccctcag caagaggaag cgctgccaat ctcagtattg caagaaaaag 828901 aataaagcgt aacaggaggc tgatgatcag cctctttttg tttgcagcac atttacacga 828961 attcttaaag aaaaaatcat tgaattcact tgaaaaatct tttaagatga aactcgttgt 829021 tttttaaaat caaaggaggc gatgacgttg agtatcaaaa acccatctgt aaaatttatt 829081 atatttgttc ttatgatttg tacattttca atcggctata cagaatacgc ggtgatgggt 829141 attttgacgt cgattgccaa tgactttcat atacaggttt catccgcagg gcttcttgtc 829201 acggcttatg cggcaagcgt ttgtttgaca gggccgctcg tcaccatcat ttccgtcaag 829261 cttccgagaa agcctgtgct tcttgggctg atggcgatat ttatcctttc caacctgatg 829321 agcgcactgg cgccgaattt tgcggtattg gccatttcaa gaattttatc tgcgtccatt 829381 cacggcgctt tcttcgcgat tgccatggta ttcgcaagtg aaatggttcc gccggaaaag 829441 cgtgctgcag ctgctgcttc aatgaacggc ggactgacag tggctctaat gcttggtgtt 829501 ccattcggct cttatctcgg agatgtcctg aattggagag cggtgttttc catcattacg 829561 gcacttggtg tcatcggatt tttaggcctt atggctgccg tgccgaacag aaaaccaaaa 829621 gtgatcccaa tgcttatgaa tgagtggggt gtttttaaac acaaacaagt gctgttttcc 829681 ttcgcgatta ccattttagg ctattccggt gtctttatcg cctacacctt tatcgaaccc 829741 attttgaggc attcagccgg attcagcacg gttggcatta caggtgctct ctttgcgtat 829801 ggattgggag gcgttgccgg gaatttcttt gctggaaagg taccgctgcc tttgctgact 829861 cggacgatga tcggcgtaat gatcggttta atcggtgttc tggctgtatt tccttacatc 829921 gccatttacc cggctgcagc cattgtggca acgttcctat tcggggcatg cgcattcggc 829981 acgccgcctc ttctgcaaac aaaggtcatt tcctcatctg agggcggcac aaccattgcc 830041 gcagctgtca gcgtatcagc atttaacctt gccaatgccc ttggtgcatg gatcggcgga 830101 atgattttaa acggaacagg ctcttattcc tggctgtttg caggaggtgc gcttatgacc 830161 gcatgcggac ttgtgctttc taccttcgca cacttatcag aaaagaagag cgtctacgaa 830221 tatcaagtca ataaagggta aaaaacagct gcagtgtatg cagctgttct tctttaccgt 830281 ttgcctgagg ctctcattct ttcttgagga tgctgattga tagatccgtc agcacgcttt 830341 gaagcatagt cgtcctttgc tctcggttca ccctgaaatt tgttttcgtt ttcgtaagga 830401 aatccttttt ctttatttcg gaccatgtca tatcccccta ggttcgagat caaaaagttg 830461 cgtcttttca gatgaagacg taaggttagt atatggagaa caccacgtaa taaagcgtta 830521 tttttttcct gaagaaagga gactgcacac atgaatatgt acattgagaa actgactaat 830581 ctgcttctgg aaaagaacga gatgatcagc tatatacagg caaaaacgtg ggtggaattg 830641 ttatggagcg atttcgaagc aacctacgca aaagccggac acgcctatca aggtgaaaaa 830701 atgactgaaa aaatcgtcac acaatggatt gaaaactatg gcggccagct ccaccttttt 830761 caaagctccc gtaacgacgt gaatgattac ttaaatcaaa gcagaggcct tttgcattaa 830821 aaacctgccg ttaacgaccg gcaggttttt tcattttctt aaaattacct taacaggaag 830881 aaatcataaa caaaacatgt ttcaccagcc tgtcaatcag ggaataccac ttatatcttg 830941 tcaaaatgcg aggaggagct ttatatgaaa aagaaacaag taatgctcgc tttaacagct 831001 gccgcaggac tgggtttgac agcacttcat tccgctcccg cagcaaaagc tgcgcccctt 831061 cacgacatat ctgtcagcat gccatcatcc gatacttaca tcataaaagc aggaaagctg 831121 aatgtccgga ctgagccaaa tcatgaaggt gatattctcg gcactgtatc atcagaacaa 831181 aaggtaaaag tcgataggtt cgtaaatgcc gattgggctc aaattcattt caaaggaaag 831241 aaagcatata tttcaactca ctttttaatg aaaaccgcaa gccaagcgaa aacaacgaaa 831301 cagacagcct tctatacacc gacgcccgaa aacggaaaag ctaagcagct ctcatctgga 831361 acagaggtga caatacttgg gtggggattc agtgaaaacg gcggatttga cttcacttgg 831421 gcgttcgtgg attatggcgg agttaaaggc tatattcaca caaaggattt acaaatgcga 831481 taaaaaggca ggccgaggct tgtctttttg cctatgcatg aaacatttct tctttctgca 831541 cgtaacaatg agaaaggaga tgatgatatg acgggtttag tcggcggagg gcttatgatc 831601 attgcgggca tactgatcaa actgtttcct cccaaatcga tcaacagtgt gtacggatac 831661 agaacgagac gctcaatgtc agatcaaaga ttatggaatg aagcgaaccg ttacagtgca 831721 tcattaatga tcctgtcagg cttggtgatt gcgggaatgg gtttgctgct gggatcaaac 831781 ttgtttattc ttcagcttat cctgctgatt gccgcctgtg tcataacatt tatgctaacg 831841 gagaaaaggc tgaaaatcat gacgcacagt caaggaggag atagaagtgg acggagttaa 831901 atgccagttt gtcaatacga acggaatcac gcttcacgtt gcagccgcag gacgggaaga 831961 tggcccgtta attgtcctgc tccatggatt tcctgagttt tggtacggct ggaaaaatca 832021 aatcaaaccg cttgttgatg cgggttaccg ggtcattgct cctgatcagc ggggctacaa 832081 tctcagtgac aaaccggaag gaattgattc gtatcggatt gatacattaa gagatgatat 832141 catcgggctt attacgcaat tcactgatga aaaagcaatt gtcatcggtc atgactgggg 832201 aggagctgtc gcatggcatt tggcttccac acgcccggaa tatcttgaaa aactgatcgc 832261 gatcaatatc ccgcacccgc acgtcatgaa aaccgtaacg ccgctttatc cgccgcaatg 832321 gctgaaaagc tcgtatatcg catacttcca gctgcccgat ataccggagg catcactaag 832381 ggaaaatgat tatgatacat tagacaaagc gattggatta tccgaccgtc ccgcgctttt 832441 tacatccgag gatgtcagca ggtacaaaga agcgtggaag cagccgggcg cgctgacagc 832501 tatgctgaac tggtacagag ccctcagaaa aggaagcttg gcagagaaac cctcttacga 832561 aacagtacct taccgaatga tctggggaat ggaagaccgc tttttgagca gaaagcttgc 832621 gaaagagacg gaaaggcatt gcccgaatgg acatctcatc tttgttgatg aagcttccca 832681 ttggattaac cacgaaaagc cagccatcgt caatcagctg attttggaat atcttaagaa 832741 ccaataagct aaaatttctc tccatccgtc tgtcataatg gcagactttt tctgtgcgtt 832801 ttttttcata gtctgtttta aacatgacaa aataacatta aaaatcatga atgtcaccat 832861 aaaattgtaa caaaaaacag gtttaaacga ctttaaaaaa aggaatagcc ttactgaaga 832921 tttgtgtaaa actcccctaa ggcaatactt aaaaagaata ataaaaagaa ggtgccttaa 832981 tgaagcaagg attaatctcg attattatcc cgtcttacaa tgaagggtat aatgttaaac 833041 tcattcatga atctttaaaa aaggaattta aaaacattca ttatgactat gaaatattct 833101 tcataaacga cggaagtgtt gatgacacgc ttcagcagat caaagacttg gcagcgacgt 833161 gcagccgggt aaaatatata tctttttctc gaaactttgg aaaagaagcc gcaattttgg 833221 cgggctttga gcatgttcag ggcgaggcgg ttattgtcat ggatgccgat ctgcagcatc 833281 cgacatattt gctgaaggaa tttatcaaag gctacgaaga agggtatgac caagtcattg 833341 cccaaaggaa cagaaaaggg gacagctttg tccgctcact cttatcatct atgtattaca 833401 agttcattaa taaagcggtg gaagtcgatt tgcgtgacgg tgtcggtgac ttcagattgt 833461 taagccgcca agctgtgaat gcacttttga agctgagcga aggaaaccgc ttctcaaaag 833521 gccttttttg ctggattggc tttgatcaga aaattgtatt ttatgaaaat gtcgaacgaa 833581 aaaacggcac ctccaaatgg tcgttcagca gtctgtttaa ctacggaatg gacggcgtcg 833641 tttcatttaa tcataagccg ctgagattat gtttttatac aggcattttc atcctgctgc 833701 tttccatcat ttatatcatt gccacattcg ttaaaattct gactaacggt atttctgtgc 833761 ctgggtattt caccattatc tcagcagtgt tatttctcgg cggagtacag ctgttaagtc 833821 ttggaataat aggtgaatat atcggccgaa tctattatga aacaaaaaaa cgcccgcatt 833881 atttgatcaa agaggcgaat atcccgaaca aagacctgcc tgaaacgaac gaattaaaaa 833941 gcatgcggcg tctgacaaaa atgcactgaa aataccaagc gccattggca gtgctttttt 834001 tgcgtgtcta ttatcttaaa agcaagactg gagaattcat atgaaaagaa aacatatcat 834061 gatctatgcg gccagtttgc tggtgtccgt tctggcacac gctttttttg tgaaagaatg 834121 ggcggaaggc aggtatatga caggtccggg tgacgggctt gcgcaaatga tcgtatttaa 834181 aaaattatta tttgaccaat atacacacgg gaattttttc tacaattatt cattcggact 834241 tggcggcggc acattcagtc agctcggcta ttatttttct gcgtcttttc tttttcttgc 834301 tgtgtctgcc gctgtttggc tgcttcaagc cgtccagctg atcggagaaa cggatacgct 834361 tttttgggca gagtcagctg tttttatcag tattttcaaa ttgagcttga tcatctttac 834421 gtccgcttct gtttttcatt atcttcttaa gcacagggcg gcatcgttca cgggagccgt 834481 gttatacggc gtctcaatta tttatttccg tcacgaagcg tattgggaat ttttcaccga 834541 tacaatggtt tggcttccgc tgcttgtgct tggcgcagaa aaaattatta gagagcggcg 834601 tccggcgtgg tttatcgttg cgtgttcgct gacgttaatc aacaattttt actttgcata 834661 cataaacctt atattcatcg gaatctatgt gctgttcaga tggctgatcc gtttggaacc 834721 acatgaagag aaaagatgga ttcaaatcag attatttctc gtttcaggct tcatttcttt 834781 tggcatcagt gcggcggcgt ttgtgccggt agtatacggt tttttaaaca acctgcgccc 834841 tccatacagc cagaaaatag agtggctcaa tttcgatgat aatatcttat tttcgagccg 834901 gatcatcatt gtgccggccg cttttctgct gtttttgttt attatttctt tttacaaaaa 834961 ccgtgtgttt cgtctctttg ccgggttgag cctgctgttt attctgtttc atttcagtcc 835021 gtatgcggca agcgtcttta acggtttttc cgccccgcaa aaccggtttg aatatgttct 835081 ggcctttacc attgcgggag cagctgcggc tggtttgtca cagctgtctg aattgaaacg 835141 gaaagaactg ctcccggccg cagctgtcgt cctgcttctt tacttgtatc atatccaaag 835201 gtataagctc gatatatgga agcctgcgaa tgaaagtatt ctattgctct tactcatgac 835261 aatcgcagcc ttgtttgctg cagcttttgc gaaaaaacgg gcaaaaatgg ctgtgtacgg 835321 tataatcatt ctttcttcgc tgtttgtcgc caactcctat caaaaatacg cgctctcaga 835381 aggcggcgat ttggacagtg tgacaaaaga atatcttaca agtgaggaat acagagggcg 835441 ggaatcatct gagctcatca gacgtttaca gaaggaagac gatgacccgc tcatgagaat 835501 cgactggatg aacggggtcc gcaataatac gccaatcatt tacggattta atggcttcag 835561 cgcgtattcc agcattttaa acaaagatct gctggccttc tattggaatg atttaagcat 835621 cgatatgggc agggaaagcg tcagccgtta cgcgtcattg ggagacaggg cgaatttata 835681 cagcctgctt tacggcaaat attatatgac cgaaaaaaca aacgaagcca gcgtcccgta 835741 cggcttcaaa aagcatttag aaacagagca ttatgcagtt tatgagaatc agtacatgct 835801 tccattcgtt aaaacagcgg atgccatata cagcgaaagt gagctggacc gattgcccgc 835861 tcttgcgaaa gaacaggcga tgctgaaagg aattatatta aaagatccat caggaaaaac 835921 ggagcagaca ccaaaaccgt ccaatttgat caccaagtcg gacatcaccg caaaacaagc 835981 ccagtatcaa aacgggctgc taaccgtaac tggagaaaac ggaggagagc tgatcatcac 836041 cccgaaacag ccatcatccg ctccgggaga ctactatgtc agcttttatt tgaaaagcaa 836101 agcaaaagac aaaggattta cattaaaggt aaatgattat gtcacaacaa ggaaatcgaa 836161 caaatcgatc tataaaaccg gagtaaataa tataacggta agagtgccta aatcaggcca 836221 tatctcaatc aatcttccga aaggaaccta tgagctgaga aacatagcgc tctatgaaga 836281 aaattaccaa acgctgaaaa acgctgtaat gcaaaataaa acagagaaag cagacaaact 836341 gaattggaac aaaaatcgac tgaccttttc ctatcatctg tcaaaagacc agtacatcat 836401 gcttccgatc ccatatgaaa aaggctggga gctgaagatc aacggaaaaa cacagaagat 836461 cgaaaaagcg gattatgctt ttataggctt caaggcgcaa aagggagaca atcacattga 836521 gctgacttac tatccgccat acttcaaaat atcggcgatc atatctctcg tcagtctgct 836581 gcttgctgtt ttttatataa gacgtaaaaa gcccggctct atatagagcc gagctttaat 836641 tttttctgaa gtttttcttc gctgaatatc catcccgtat aggatgaacg aatcgtgaga 836701 tcatggccga tatgaacaat tgcgacaaac ggataatggc ctttgctccg ataacgcagg 836761 tcgataaatc tcacctcata atgatcttta aacgtatcca cttcccaccg gtataccgga 836821 gaaaaggaca gaaacgccgc gatgttatca tcctgctttg ccgcatgcat tacatcggtt 836881 tcaggaacag gcacccgatt aaatgtatcc agaatcacga catgtccttc catgcttctt 836941 cctacataga aagcatgtgc tgtcgtcact gcgattcgcc attgcctgaa tttcatcgtt 837001 ggagaaataa taatgctttc gatctcatca tgaatcatct catgaagctt ccgtttaatt 837061 ctcagctgca tgatcaggcg caccaagtag tagcctacca atatgatata taagctgaga 837121 aacgtgatgc cgggactccc gcctgcatac caaatcgcga tagctgccag atggctgata 837181 aaaataaacg gatcaaacgt attaatcagc ccgagcgcaa cccatttttt cgaaaacgga 837241 cgaatggctt gtgttccata ggcgttgaat atatcaacaa agacatgcag aacgactgcc 837301 agcagtgtcc acagccacag gtgcagaaaa tcggcctgag gataaaataa atacagaatc 837361 gccgggatga tgacagacca aaacaaaacg gcgggaattg aatgggtaaa tcctctgtga 837421 ttccttatat aaacagcatt gtttttaagc tttaacacag tatcaatatc cggagcctga 837481 gagcccgcaa gcgttgcgat cataacagcg tgagccattg ccggatctga tccgacaaca 837541 ggatcaagcg tcgcaatacc gcccagtgcg atgcccataa cgacatgtgt gcccgtatcc 837601 ataggtgacc tccttgcagg gtgatcctgc acattcactt tgtaagaaat tccccatttt 837661 catataccca atttttaaac tgattcaatc gttctcatat gtttccgctt tttctttatt 837721 actatttaat gtaacatatt atcgtactgt gcccttagtg tacaacaaaa aacagtctaa 837781 agaaaagcgg ggcgcgaaag actggggaga aacacatatg aacgtacttg aagacaaatt 837841 aaaacaaaaa gacatacagc aatttcgcga tgatttaatc tcatggtttg aacgagagca 837901 gcgcgttttg ccgtggagag aggaccaaga tccatataag gtgtgggtat ctgaagtgat 837961 gctgcagcaa acgagagtag agacagtgat tccttacttt ctccggtttg tagaacaatt 838021 cccgacagtg gaagcgctcg ctgatgctga tgaagaaaag gtgctgaaag catgggaagg 838081 gctcggctat tattcgcgag tcagaaacct gcaaagcgcg gtaaaagaag tgaaacagga 838141 atacggcggc attgttcctc cagacgagaa agattttggc gggttaaaag gcgtcggccc 838201 ttatacaaag ggagcggtgc tcagcattgc ctacaataaa cccattcccg cggttgacgg 838261 aaatgtgatg cgtgtcatgt ccaggattct atctatttgg gatgatattg ccaaaccaaa 838321 aacaagaacg atctttgaag acgccatacg agcttttatt tccaaagaaa aaccatctga 838381 atttaatcag ggcttgatgg agcttggagc cttgatctgt acgccaaaat caccctcatg 838441 cctgctttgc ccggttcagc agcattgctc agcatttgaa gaaggcactg aacgggagct 838501 tccggtaaaa agcaaaaaga aaaagcccgg gatcaaaacc atggccgcga tcgtactgac 838561 tgatgaagac ggacaagtgt atatccacaa acggccgtct aaaggtttgc tcgccaacct 838621 gtgggaattc ccgaatcttg aaacacaaaa agggatcaaa actgagcgtg aacagctcat 838681 tgctttctta gaaaacgaat atggcataca agctgatatc agtgatctgc aaggtgtagt 838741 cgagcatgtt ttcacccacc tggtatggaa tatttcagtg tttttcggta aagtaaaaca 838801 agtgtcggat accagcaagc tgaaaaaagt aacgaaagaa gagctcgaac aatttgcgtt 838861 cccggtgtca catcaaaaaa tctggaagat ggcaggagaa gcagccgcca tctcggctgc 838921 tccgtaaacc attcttaatc gtaagagacg cgcgtgccgt ggctgtagtc cgcttcattg 838981 cgcttcattc cgccgcgcgc ttcaatttct tgcgttaatt cccggtattt tgattggcct 839041 tcttcgttca aataaggcat aatttgctga aaggcatgat gaaaataagc gagttcactg 839101 ttcttccaat cttttttgga aaccatgttc aattcgctca tatcacgtcc gacatacata 839161 acagaagacc ccctttaaag ttcttgccat tattgtttgt ggaaataaaa gaactatacg 839221 ctacaaggag atgaggaaaa atggaacaaa ataaatgtgc actcgtaaca ggaagcagcc 839281 gcggtgtcgg aaaagcggcc gcgatcagac ttgctgagaa cggctataac atcgtcatta 839341 actatgcacg cagcaaaaaa gcagcattag aaacagcgga agaaatcgaa aagcttggcg 839401 ttaaagtgct tgtcgtaaaa gcaaacgtag gacagcctgc aaaaatcaaa gaaatgtttc 839461 agcaaattga tgaaacgttc ggcagacttg atgtttttgt caataatgcc gcttcaggag 839521 tactaagacc tgtcatggaa ttagaagaaa cacactggga ctggacgatg aacattaatg 839581 cgaaagcatt gcttttctgc gctcaggaag ctgccaagct aatggagaag aacggtggcg 839641 ggcatattgt cagcattagt tcattaggct ctatccgcta tcttgaaaac tacaccacgg 839701 tcggtgtatc aaaagcagcg ttagaggctt taacccgtta tcttgccgtt gagctttcac 839761 caaaacaaat tatcgtcaat gctgtttcag gcggagcgat cgacacagat gcgctgaagc 839821 acttcccgaa tagagaagat ctgcttgagg atgcgcgcca aaatacgccg gcgggacgca 839881 tggtcgaaat taaagacatg gttgatactg tggagtttct agtgtcttcc aaggctgaca 839941 tgatccgcgg acagacaatt atcgttgacg gcggacgctc actgctcgtt taaaaatttt 840001 taaaaaagag gaatagctat acgatcacct gcacattcta atgaccgtgg aggtgataac 840061 aatggctaac tcaaataact tcagcaaaac aaacgctcaa caagttagaa aacaaaacca 840121 acaatcagct gctggtcaag gtcaatttgg cactgaattt gctagcgaaa caaacgctca 840181 gcaagtcaga aaacaaaacc agcaatcagc tggacaacaa ggtcaattcg gcactgaatt 840241 cgctagtgaa actgacgcac agcaggtaag acagcaaaac caatctgctg aacaaaacaa 840301 acaacaaaac agctaatcac tgaaacagaa aaaagcactt catcttcggg tggaagtgct 840361 tttttctgtt tgaaaaacga caaaacttgt ggaaggtcta cagaatgagt caaagggttt 840421 gctttatgga gatcgaaatg attaaaggag gaaatgttta tactttcatc aggctgaagg 840481 aggaaccgat gaccgaattt gaaaagctgg taagtgaaca gatgaaaacg atggataagc 840541 ttctcgatct ccaatcagag ctcgaccgct gcaaacaaat tgaggcggaa ctccggcatt 840601 tggaaaggga tgcaaggctg cgtgggattc aggctgaaat tgcggtaaaa cggaaacacc 840661 ttgccgatat acaggatatg tttcaaaagc agacagagca ggtcattcgt tcatatcgca 840721 gctcagaaaa gccgtcttcc tttgtgtagt gcaggaatgt gccattcccc ggccggaatg 840781 gctcttttat tttcattttt caatttgtaa cgttataata ggtaaaagac gttgtcggta 840841 agcaaatttg gacatactaa ctgtagggct ttatagaaag taggggagaa atatgggcta 840901 tcccaaggaa ggagaaacca ttcaaattca cagctataag cacaacgggc tgattcatag 840961 aatttggaat gagacaacaa tcttaaaaag tacagaaatg tgtgtcatcg gagccaatga 841021 ccggacgatg gtaaccgaat cagacggccg gacatggata accagagagc ccgcaatctg 841081 ttattttcac gcaagacaat ggtttaatgt catcgggatg ctgagggaag acggggttca 841141 ttattattgc aacatcagtt ctccgtttgc ctatgatggc gaagcaatta aatatattga 841201 ttatgactta gatgttaagg tttttcctga catgacctac aatattctcg atgaagacga 841261 atatgatgat catcggaaag ccatgaatta tccaaaagaa atcgacagta ttttaagaga 841321 ctacttaaat acgctgctcc attggattca ccagcgtcag ggaccgtttg cgcccgagtt 841381 tgtcgatatg tggtatgaac ggtatttgcg ctatacaaaa taatggttac gtaaaaacct 841441 gttgcggggt acaacaggtt tttcacatgg gctcacacac atcatgataa agagagaggg 841501 ggaatcaacc gtgggggtta tgaaacgcta catgcaattc gtcaaacctt ataagaagca 841561 aattttcgtt acagtgttaa tcgggatcgt aaaattctcc attccgcttg ctctcccatt 841621 gcttctgaag tacgtagttg acgacattat tcaaggaggc ggcacggcca gtgacaaaac 841681 cacgtcattg ttcacgatta tggcgatcat gttcgcctta tttttaattt tgcgcccgcc 841741 tgttgaatat taccggcaat attttgccca gtggactgcc agcaaggtgc tttatgatat 841801 aagagctaag ctgtttgacc atatacaaaa actgagcctt cgtttttacg cgaatacaag 841861 aacaggggaa gtcatttccc gagtgattaa tgatgtagaa caaacaaagg atttcgtcat 841921 cacagggctg atgaatatat ggctcgatat gctgacgatt ttgattgtaa tctctatcat 841981 gctcacactg gacgttaaat taacgctgat ctctatcgtt ttattcccat tatacggaat 842041 atcagtgaag tatttttacg gccgtttacg aaagctgaca agggagcgct cacaggctct 842101 tgctcaagtg caggggcatt tgcatgaacg cattcaaggc atgcctgtca tcagaagctt 842161 tgcgatagaa gatcatgaac aggctcaatt taatgagaaa aacggtcatt tcttagataa 842221 agccatccgc cacacgaatt ggaacgcgaa aacctttgcg gtcgttaata ccattacaga 842281 tttggcgccg ctcatcgtca tagcgtgcgc cgggtatttt gtcattaatg gaccgctgac 842341 agtcggaaca atggtcgcgt ttgtcggata tattgacaga atgtacaacc ctgttagaag 842401 gctgatcaat tcctctacaa ctttgacaca gtcaatcgca tcaatggaca gggtgtttga 842461 atttattgac gagccctatg aactcactga caaaccaaat gcgataaagg ccgatcagat 842521 tcgcggagga gtggagtttc aaaacgtttc gtttcaatat gagaaggaca aagaaaatat 842581 tcttcatgat gtatccttaa aagtaaatag aggagaaact gtagctctcg tcggcatgag 842641 cggaggagga aaatcaacgc tcgtcagcct gatcccaaga ttttatgatg taacaagcgg 842701 cagactgctg attgatggga cggatattcg cgattatgaa gcaagaagcc ttcgcaacca 842761 ggttggtatg gtgcttcaag ataccttttt atttagtgaa acgattcggg aaaatatcgc 842821 gatcggcaag cctgatgcca cacttgaaga gataatcgaa gccgccaaag ctgcaaatgc 842881 ccatgaattt atcatgagtt ttccagaagg atatgagacc cgggtggggg aacgaggcgt 842941 taagctttca ggcggacaaa agcagcggat ctcaattgcg cgggtattcc tgaaaaatcc 843001 gccgctcctc attttagatg aagctacatc agctctggat ttggaaagtg agcattacat 843061 tcaagaagcg atggacaaac tggcgaagga tagaacaact tttgttgtcg cccaccgttt 843121 atcgacaatc acccatgcgg ataagattgt tgtcatggaa aacgggacaa tcattgaaat 843181 cggaacccat gatgaactca tggactatga gagccaatac aagcacttat ttaccattca 843241 aaatttgaac taaaacatca atcttatatc cttttaacga aggatataag atttttttgt 843301 atataaaaaa acccggctgt ttaaccgggt tactcttctg tttctatttc gcagtctttc 843361 ggatgatacg tttgaaaact tgtgataagt gtttctaaat gttcaagctg ctcgcgatat 843421 tccacggcgc ttgccataat attgagcatg ttgtaatcaa taagctcctc atccgtattc 843481 tgctgatttt ttaaaaatga ctttgttaaa agctgcttat accggatgcc ttcttcaacc 843541 gcgtcatcat gcggcttgat ttttccgaca aacctcatca aaatccgctc gtgccagtaa 843601 agcaggtaat caagttcttc agtcaatgtt tcctgaaact cttccggcat atgatagatc 843661 tcgttttcca gacgatgcag cttcttcaat gtatcaagcg cccgatttgc agtaataatg 843721 gcctgtctga acaggacaag ctttcttgat ttcacataag tcgttttctt aaagtaactt 843781 ctttcttctt tatatagaag atatgtctga tcaagcttga tcattttttc tttcagtttt 843841 tcaatatcct ctttcaaaat cgaatgctct gtcgactgcc gcatggacaa tctgatccac 843901 ttcataattt cttcggtgtt ttcgacggta ttatgaatca gctttgtttc gtacttagga 843961 ggcaaaaaca caaggttgac gataaaggaa gaaagcaccc ctaagatgac tgtgcttgtt 844021 ctgatcagcg cgaacattaa aaagtcgtca ccggcagatt ctaatatcgc aatgactgtt 844081 acaagagcaa ttgaaattgt atgttcaatt ttaagtttca gcatgattgt aatgacaata 844141 actgctgtta acccgatcat aatcgggctg ggtccgaaaa taaggccgaa cactgtggca 844201 atcacagctc cgatgatatt tgcttgaacc tggtcaataa taatgagaaa agagcggtaa 844261 atcgacggct ggatcgcaaa tatcgctgca attccagcga aaatcggcgc gggaagcccg 844321 atccacgaag ccaaataaag ggcaagtgta atcgcaatcc cggttttgaa aatgcgggca 844381 ccaagtttca ttggtttgtg cgtgcattcc tttctatagt aaattgtgtg acatagcaaa 844441 tgggctaatc cttaaaattc ccggttagtt tatttgctaa acaattaagt aatatacagg 844501 gatcgataca aatattcaag ctatttttct agaaaaagac caaaatctta cacgctgttt 844561 gattccataa aaaaacagga gctcaaagct cctgttcaag gtatttgatt ctagtttttt 844621 agatgtttaa atgcatcctc gaccgctgta agcgtgtctt taatatcctg ctctgtatgt 844681 gctgtggtaa taaaccaagc ttcatactta gaaggtgcta aattaattcc gcgttccagc 844741 atcagcttga aaaacgtaga gaatgtttct ccgtcactcc gttcagcctg ctcgtaattt 844801 tccactttct catcagagaa gtataccgtg agcgcacctt ttaaccggtt gaccgtaatg 844861 gtgatgccgt gtgtttctgc gtgcttcaaa atgccttcct caagcatagc gccaaggtga 844921 tcaagctttt catacacgcc tttttctttg agcacttcca gacaagcgat gcctgatagg 844981 atggaagcgg ggttccctgc cattgttcct gcctgataag caggccctag cggagctacc 845041 tgctccatga tttcttgttt gccgccatag gccccaatcg gaagtccgcc gccgataatt 845101 ttcccgagtg ctgttaaatc tggtttcacc tgtaagagat cctgcgcgcc gccatacata 845161 aagcggaaag ccgtaatgac ttcatcgtaa ataacgagag cccctgcatt atgtgttaat 845221 tcatttactt gttctaagaa gccctctttc ggctccacga taccgaagtt gccgacaatc 845281 ggttcaacga gaaccgccgc gatttcactg ccccattttt caagagctgc tttatagcta 845341 tcgatatcat taaatggtac tgtgatcact tcgtttgcaa tgcttttcgg tacaccggct 845401 gagtctggtg tgccgagagt agacgggccg gagcctgcgg cgacaagcac aaggtccgaa 845461 tgcccgtgat agcagcccgc aaatttaatg atttttgtcc ggcctgtata tgcgcgagcc 845521 acgcggatgg tcgtcataac ggcttctgta cccgaattga cgaatcttac tttgtccata 845581 gcgggaatgg cttctttgag catttttgca aatgtaacct cgtgtttcgt tggtgttcca 845641 tacaatacac cgttctctgc tgctttttta atcgcttctg taatatgcgg atgggcatgt 845701 cctgtaataa tcggaccgta cgccgctaaa taatcgatgt atttgttgcc gtccacatcc 845761 caaaaataag cgccgcttgc tttctccatt gcaacaggag aaccgccgcc gactgcttta 845821 tatgatctag acgggctgtt tacaccgccg acaatgtgct gtaatgcctc attgtgaagt 845881 tcaattgatt ttgtatgcaa gaataaaaac ctcctatatc tccatgcgtc ctttctattg 845941 tagcatgctt ccgaacaaga acaatggctt cgggcttcag attcagctga gatggttgta 846001 atctggacaa gaattggata cgcttaataa aaaaacatcc ggaggtaacg taatgactat 846061 agaaatcgga caaaaagcgc ctgatcttga gttaaaaggt gatcatgggg aaacagtaaa 846121 attatcggat tataaaggaa agtacatcgt gctttatttt tatccaaagg acatgacacc 846181 gggatgtaca actgaagcat gcgattttcg ggacagtcac gaaagcttcg ccgaactgga 846241 tgccgtcatt atcggcgtca gcccggacag ccaggaaaaa cacggaaaat ttaaagagaa 846301 gcataacctt ccatttctgc ttcttgttga tgacgagcat aagctggcgg aagcatttga 846361 tgtgtggaag ctgaagaaaa acttcggaaa agagtatatg ggaatcgagc gttccacttt 846421 tttaattgat aaagaaggcc ggctcattaa agaatggaga aaagtaaaag taaaggacca 846481 tgtagccgaa gcgcttcaaa ccctcaaaga tatgtctgaa aagtaaatct ctatgagcct 846541 atgcttactt ttaccctgat atcaattgac aaattatcgt agaaagagtt acactaatta 846601 taaacattac aatgtaagaa ttttttttag aagagaggtg catgacggat ggctgcacat 846661 gaactaaaag aagccttaga aacgttgaag gaaaccggag ttcgcattac tcctcaacgt 846721 catgcgattc tggaatatct cgttaactct atggctcatc caacagcgga cgatatatat 846781 aaagctctgg aagggaaatt tcctaacatg agcgtagcga cggtatataa caatttgcgt 846841 gtgttccggg aatcaggttt ggtaaaagag ctcacatacg gtgatgcttc cagcagattc 846901 gattttgtca catccgatca ctatcacgcg atttgcgaaa actgcggtaa aattgtggac 846961 ttccactacc cgggccttga tgaagtggag cagctcgctg cccacgtcac gggcttcaag 847021 gtaagccacc accgtttaga aatttacggc gtctgccaag agtgttcgaa aaaagaaaat 847081 cattaaaaat aagctgaccg cacgaaacgg tcagcttatt ttatttcgac attttctttt 847141 tattataaga ctcatcaaat tcttttcctt ctaatccctt atctaaagtc agcggctctc 847201 ggcaatgcat gcacatatcg actactccta aaacctttgt ctctttatca cagcctggac 847261 aaatgacgcg aaccgcttta gtcgaaagca ttccgatcca aaagtaaact accgtgctga 847321 gaccgatgga taaaagccca agtatcataa acaaactaga aagcaaaact gactctttga 847381 aaaagatccc gatgtacata atgataaacc caacgaaaac caaacttaac gcaaatgttc 847441 tgattttatt aattttgctg gagtatttcg ccatgtccat ccccctctgt tttaactata 847501 gcacaaaccc gatgggattt tcttcatgtt ttcggttgaa ctggaattta catatggaga 847561 gttactgtga aattgtttat aatagttcaa tgtgtttaga aaaaaggaat ttcgttttaa 847621 ccatagaatt gaatcaaata gagaataaaa aaatttgaac aattgcattg gaggaatagt 847681 gatggaaaat cttctccgtc caatttacca agaaagagca agtcacccca atacattggc 847741 tgtcattatg attgagagaa gaaacaaaac atcttcctta acagataact ttgatgcagc 847801 tttgctggtg attgtaaagg atgctgatga gccagttttt ataaagcatt atgaatttga 847861 tcatcaaaca gcttctttgc atgtggtaac agattctcag attcaagaat ggattttgct 847921 tggaacaaat agaagaatca tagattggat tgtaaatggc agagtcttgt ttgaccgtaa 847981 tgaatacgta gttgaactga ttgacaggct gaatacattt ccgtttgccg aacgtaaact 848041 gaagatcgga ctcgaatacg gcaaattaat cagaaggtat gttgaaggga aagctttttt 848101 tgaagccaat caatttttag atgcctacaa tgccgttgtt catgcgctgc atcatttagc 848161 acgtattgaa gtaatcgaca gaggattcca tcccgaaacc acggtgtgga gccaagtgcg 848221 ccagatggag ccccaagtgt acaaattata ttccgagctg attgaaagtc atgagagcct 848281 ggaaaaaaga cttgaattat tattcttagc aaatgatttt ctcatccatt ccaaagccga 848341 gatcggttcg gcgcatcttt tcgaagtaat gaaagaaaaa gacatttggc aattcggtga 848401 gcttcttcaa catcatgacc taaagcactt tacccaagat cttggcgtta tgcttgatta 848461 cttgacggaa aagggactta tcaacgtctg ccagatagaa acgaaaggac aggctgtcta 848521 tcaccgagga tattctttta aaaaaggtgt tgactctgat tcttgaccgt gttatattat 848581 taaacgtcgc tgatgcgctt ctgagaaaac aagctcacag cggcgggaaa ataaatcaaa 848641 aaaacatttg acaaaagaaa gtcaaaatgt tatattaata aagtcgcttc aacaagaagt 848701 gaaaatgatc tttgaaaact aaacaagaca aaacgtacct gttaattcag tttttaaaaa 848761 atcgcacagc gatgtgcgta gtcagtcaaa ctagggcctg cacgacgcag gtcacacagg 848821 tgtcgccgca ggatgcggtg aacttaacct gtgatccatt tatcggagag tttgatcctg 848881 gctcaggacg aacgctggcg gcgtgcctaa tacatgcaag tcgagcggac agatgggagc 848941 ttgctccctg atgttagcgg cggacgggtg agtaacacgt gggtaacctg cctgtaagac 849001 tgggataact ccgggaaacc ggggctaata ccggatggtt gtttgaaccg catggttcaa 849061 acataaaagg tggcttcggc taccacttac agatggaccc gcggcgcatt agctagttgg 849121 tgaggtaacg gctcaccaag gcaacgatgc gtagccgacc tgagagggtg atcggccaca 849181 ctgggactga gacacggccc agactcctac gggaggcagc agtagggaat cttccgcaat 849241 ggacgaaagt ctgacggagc aacgccgcgt gagtgatgaa ggttttcgga tcgtaaagct 849301 ctgttgttag ggaagaacaa gtaccgttcg aatagggcgg taccttgacg gtacctaacc 849361 agaaagccac ggctaactac gtgccagcag ccgcggtaat acgtaggtgg caagcgttgt 849421 ccggaattat tgggcgtaaa gggctcgcag gcggtttctt aagtctgatg tgaaagcccc 849481 cggctcaacc ggggagggtc attggaaact ggggaacttg agtgcagaag aggagagtgg 849541 aattccacgt gtagcggtga aatgcgtaga gatgtggagg aacaccagtg gcgaaggcga 849601 ctctctggtc tgtaactgac gctgaggagc gaaagcgtgg ggagcgaaca ggattagata 849661 ccctggtagt ccacgccgta aacgatgagt gctaagtgtt agggggtttc cgccccttag 849721 tgctgcagct aacgcattaa gcactccgcc tggggagtac ggtcgcaaga ctgaaactca 849781 aaggaattga cgggggcccg cacaagcggt ggagcatgtg gtttaattcg aagcaacgcg 849841 aagaacctta ccaggtcttg acatcctctg acaatcctag agataggacg tccccttcgg 849901 gggcagagtg acaggtggtg catggttgtc gtcagctcgt gtcgtgagat gttgggttaa 849961 gtcccgcaac gagcgcaacc cttgatctta gttgccagca ttcagttggg cactctaagg 850021 tgactgccgg tgacaaaccg gaggaaggtg gggatgacgt caaatcatca tgccccttat 850081 gacctgggct acacacgtgc tacaatggac agaacaaagg gcagcgaaac cgcgaggtta 850141 agccaatccc acaaatctgt tctcagttcg gatcgcagtc tgcaactcga ctgcgtgaag 850201 ctggaatcgc tagtaatcgc ggatcagcat gccgcggtga atacgttccc gggccttgta 850261 cacaccgccc gtcacaccac gagagtttgt aacacccgaa gtcggtgagg taacctttta 850321 ggagccagcc gccgaaggtg ggacagatga ttggggtgaa gtcgtaacaa ggtagccgta 850381 tcggaaggtg cggctggatc acctcctttc taaggatatt atacggaata taagaccttg 850441 ggtcttataa acagaacgtt ccctgtcttg tttagttttg aaggatcatt ccttcgaaac 850501 gtgttctttg aaaactagat aacagtagac atcacattca attagtaata caagatatca 850561 catagtgatt ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta 850621 ggagccgatg aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg 850681 atccggagat ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga 850741 attcatagga tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag 850801 agaaagcaaa tgcgattccc tgagtagcgg cgagcgaaac gggattagcc caaaccaaga 850861 ggcttgcctc ttggggttgt aggacactct gtacggagtt acaaaagaac gaggtagatg 850921 aagaggtctg gaaaggcccg ccataggagg taacagccct gtagtcaaaa cttcgttctc 850981 tcctgagtgg atcctgagta cggcggaaca cgtgaaattc cgtcggaatc cgggaggacc 851041 atctcccaag gctaaatact ccctagtgac cgatagtgaa ccagtaccgt gagggaaagg 851101 tgaaaagcac cccggaaggg gagtgaaaga gatcctgaaa ccgtgtgcct acaagtagtc 851161 agagcccgtt aacgggtgat ggcgtgcctt ttgtagaatg aaccggcgag ttacgatccc 851221 gtgcaaggtt aagcagaaga tgcggagccg cagcgaaagc gagtctgaat agggcgcatg 851281 agtacgtggt cgtagacccg aaaccaggtg atctacccat gtccagggtg aagttcaggt 851341 aacactgaat ggaggcccga acccacgcac gttgaaaagt gcggggatga ggtgtgggta 851401 ggggtgaaat gccaatcgaa cctggagata gctggttctc tccgaaatag ctttagggct 851461 agcctcaagg taagagtctt ggaggtagag cactgattgg actaggggcc cctaccgggt 851521 taccgaattc agtcaaactc cgaatgccaa tgacttatcc ttgggagtca gactgcgagt 851581 gataagatcc gtagtcgaaa gggaaacagc ccagaccgcc agctaaggtc ccaaagtata 851641 cgttaagtgg aaaaggatgt ggagttgctt agacaaccag gatgttggct tagaagcagc 851701 caccatttaa agagtgcgta atagctcact ggtcgagtga ctctgcgccg aaaatgtacc 851761 ggggctaaac gtatcaccga agctgcggac tgttcttcga acagtggtag gagagcgttc 851821 taagggctgt gaagccagac cggaaggact ggtggagcgc ttagaagtga gaatgccggt 851881 atgagtagcg aaagaggggt gagaatcccc tccaccgaat gcctaaggtt tcctgaggaa 851941 ggctcgtccg ctcagggtta gtcgggacct aagccgaggc cgaaaggcgt aggcgatgga 852001 caacaggttg atattcctgt accacctcct caccatttga gcaatggggg gacgcaggag 852061 gatagggtaa gcgcggtatt ggatatccgc gtccaagcag ttaggctggg aaataggcaa 852121 atccgtttcc cataaggctg agctgtgatg gcgagcgaaa tatagtagcg aagttcctga 852181 ttccacactg ccaagaaaag cctctagcga ggtgagaggt gcccgtaccg caaaccgaca 852241 caggtaggcg aggagagaat cctaaggtga tcgagagaac tctcgttaag gaactcggca 852301 aaatgacccc gtaacttcgg gagaaggggt gctctgttag ggtgcaagcc cgagagagcc 852361 gcagtgaata ggcccaggcg actgtttagc aaaaacacag gtctctgcga agccgtaagg 852421 cgaagtatag gggctgacgc ctgcccggtg ctggaaggtt aagaggagcg cttagcgtaa 852481 gcgaaggtgc gaattgaagc cccagtaaac ggcggccgta actataacgg tcctaaggta 852541 gcgaaattcc ttgtcgggta agttccgacc cgcacgaaag gcgcaacgat ctgggcactg 852601 tctcaacgag agactcggtg aaattatagt acctgtgaag atgcaggtta cccgcgacag 852661 gacggaaaga ccccgtggag ctttactgca gcctgatatt gaatgttggt acagcttgta 852721 caggataggt aggagccttg gaaaccggag cgccagcttc ggtggaggca tcggtgggat 852781 actaccctgg ctgtattgac cttctaaccc gccgccctta tcgggcgggg agacagtgtc 852841 aggtgggcag tttgactggg gcggtcgcct cctaaaaggt aacggaggcg cccaaaggtt 852901 ccctcagaat ggttggaaat cattcgcaga gtgtaaaggc acaagggagc ttgactgcga 852961 gacctacaag tcgagcaggg acgaaagtcg ggcttagtga tccggtggtt ccgcatggaa 853021 gggccatcgc tcaacggata aaagctaccc cggggataac aggcttatct cccccaagag 853081 tccacatcga cggggaggtt tggcacctcg atgtcggctc atcgcatcct ggggctgtag 853141 tcggtcccaa gggttgggct gttcgcccat taaagcggta cgcgagctgg gttcagaacg 853201 tcgtgagaca gttcggtccc tatccgtcgc gggcgcagga aatttgagag gagctgtcct 853261 tagtacgaga ggaccgggat ggacgcaccg ctggtgtacc agttgttctg ccaagggcat 853321 cgctgggtag ctatgtgcgg acgggataag tgctgaaagc atctaagcat gaagcccccc 853381 tcaagatgag atttcccatt ccgcaaggaa gtaagatccc tgaaagatga tcaggttgat 853441 aggtctgagg tggaagtgtg gcgacacatg gagctgacag atactaatcg atcgagggct 853501 taaccatatt tttgaatgat gtcacacctg ttatctagtt ttgagagaat aagtttttca 853561 aaaaaacact tgattttctc aagaatacat agtataatgt taaatgtcac tgaaattgtc 853621 tggtgatgat ggcgaagagg tcacacccgt tcccatgccg aacacggaag ttaagctctt 853681 cagcgccgat ggtagtcggg ggtttccccc tgtgagagta ggacatcgcc aggcagactt 853741 cattccgcag tagctcagtg gtagagctat cggctgttaa ccgatcggtc gtaggttcga 853801 atcctacctg cggagccatt attggagagc tgtccgagtg gtcgaaggag cacgattgga 853861 aatcgtgtag gcggtcaact ccgtctcaag ggttcgaatc ccttgctctc cgccactgat 853921 acttatacat aattacaatt gaaagtctgg gcccgttggt caagcggtta agacaccgcc 853981 ctttcacggc ggtaacacgg gttcgaatcc cgtacgggtc attatatgat ggaggattag 854041 ctcagctggg agagcatctg ccttacaagc agagggtcgg cggttcgagc ccgtcatcct 854101 ccaccattat atcatcgcgg ggtggagcag ttcggtagct cgtcgggctc ataacccgaa 854161 ggtcgcaggt tcaaatcctg cccccgcaac caaattttaa aatggtccgg tagttcagtt 854221 ggttagaatg cctgcctgtc acgcaggagg tcgcgggttc gagtcccgtc cggaccgcca 854281 tttgaatact taggctcggt agctcagttg gtagagcaac ggactgaaaa tccgtgtgtc 854341 ggcggttcga ttccgtcccg agccaccacc tatgccggtg tagctcaatt ggtagagcaa 854401 ctgacttgta atcagtaggt tgggggttca agtcctcttg ccggcactgt tttttcaaaa 854461 tttaatgtgg aggggtagcg aagtggctaa acgcggcgga ctgtaaatcc gctccctcag 854521 ggttcggcag ttcgaatctg cccccctcca ccatttatag gggcatagtt taacggtaga 854581 acagaggtct ccaaaacctc cggtgtgggt tcgattccta ctgcccctgc caaatttatg 854641 acatcttgag attatggcgg ttgtggcgaa gtggttaacg caccagattg tggctctggc 854701 actcgtgggt tcgattccca tcaatcgccc catattatca ttgggctata gccaagcggt 854761 aaggcaacgg actttgactc cgtcatgcgt tggttcgaat ccagctagcc cagtctcact 854821 ttttatatca actgcatata atgtattaag tccattaaaa atgcggaagt agttcagtgg 854881 tagaacacca ccttgccaag gtgggggtcg cgggttcgaa tcccgtcttc cgctccaatt 854941 acggcggcat agccaagtgg taaggcagag gtctgcaaaa cctttatccc cggttcgaat 855001 ccgggtgtcg ccttcttatt gccggggtgg tggaattggc agacacacag gacttaaaat 855061 cctgcggtag gtgactaccg tgccggttca agtccggccc tcggcaccaa ttttacttac 855121 atggtaagtt gaattggtgt ttgtgtttta tcattataac taatcatatt aatgatctac 855181 ataagtagat cattttttta atgctttgat ttatcataac aagttaagtt ccgaggccta 855241 ttataaagcg gctgtatagc tagtctttca acacttttat tttatatttc cataaaaact 855301 tttttgaaat acgttgacac tttatgagat ccatgatata tttatattcg tcggttagat 855361 acgacgtaaa acttgccggt gtggcggaat tggcagacgc gcacgactca aaatcgtgtt 855421 ccttctggag tgtcggttcg accccgacca ccggtatact gaaaaacccg tttcttaaca 855481 gaaacgggtt tttatttttt attaaagaaa aggagcctcg gctccttttt atacttactc 855541 agcgtattgg tctaggatct cttctagcac ctcttctagc tcttctgtat cttcaagctc 855601 tgattggctg aaacggacgc gtacaagctg ttctccgtca ttatacatct cttccaacca 855661 ccctcggagt cctcttgctc tgcggtcgac ttcgaaaatg atttccaaac cgtcttcgtc 855721 taaaaggaaa atgagctcta attcatcaag catctgacga taatatccgg aagtcggaac 855781 gaattcgaat tcttgaacga acggaagacg acgctggaag tagggcgctt gttcgcagtc 855841 tgcttcgtta agacggaagc ccaggttttc gattgcttca agcacatttt caatccaagg 855901 gtgcgcttca acgaaaatgc ggtcatgatc ggatttatcg ataccgcctt gaatgtcaag 855961 gtctgtcacc acggcaacct ctactttccc tacagtgatc ggcgtatcta gaggcagagt 856021 gaatgtgaac ggaaattgat gctcttcacc aggctgtatg gtaaatgaac cagtgacccg 856081 gaaagaatga attgtagcgt atttccggtg ctcttcatcg tcttttacaa tgacataccg 856141 tgtgctaagc tgtaaatcga tataacggat gtcctgagcg atttttccgc ctttgacatg 856201 taccgttccc tgtacttctt ctcctggaaa atatgcgtct ttttctaaaa ttgtatctac 856261 ttttgcagct ccaattccgg cacttgccgc aagcttctta aaaaatgaca tgttagatct 856321 tccccttttt cttttttctc aacagatata cgtaagaagg aggaaaaaag attcgtttga 856381 ttcatacttt tttcctatta ttcgtctcgg cctagggaca gactaagaat aatattgaaa 856441 ataaaggagt cgatggaagt gaataaagaa agtttggttg cagatgaatt acacagaatg 856501 tttttggctg gtgagctgca aatcacagta gaggaggata taaacaatat ttccgaaagg 856561 ctgagaaacg gcgatctcag tttagaccga ttaagcggtg aagacgtgtt tataaaagaa 856621 acggtaaatg aggctttaag aagagtggag caataaaaaa gagacggcat ctcatctttg 856681 agatcccgtc tctttttgtg gtctttgctg taagataaaa gcgaatcgat ttggaattgc 856741 tcacccgagc cacccctttt ctaacagaag atctgacagt tcatcatgga gataaacagc 856801 tgtatctaat tgatcatgca atgctcttct gatgtgggga ttttcggttg ctgttgttgc 856861 gacagtgtat ttgttaatgc tggtttttat tgttgttaac aaatcaagaa tatctttggg 856921 acaaagactt tgttcaatgg gaaaccacct cctttgtttt tttagcagct cctgataaga 856981 aagtatttga ctttgtttct tgcttctata caaaatgcta taataagcaa caaattttgt 857041 tggggggtgt gatgatgaag cagattattg cgatgggggg cgggggtttt tcgatggagc 857101 cggataattt gtccctcgat caatatatcc tcaatcaatc aaaacgagag cagcctcgta 857161 tttgtttttt gccgacggcg agcggagatt cccaaaacta tattcagcgg ttttatcatg 857221 catttcaaac attggattgc gtgccgtctc atttatcttt gtttaagcca ccatcatcag 857281 atttagtttc ttttgttatg gaaatggacg tgatttatgt tggcggggga aatacgcgga 857341 atttacttgt gttatggaaa gagtgggggc tggaccatat tctcagggaa gcatggaaga 857401 acggtgtggt tgtagctgga ataagtgccg gtgcgatctg ctggtttgaa gaaggggtga 857461 cagattcagc cggaccgctg acaagtttga aaagtttagg ttttttgcaa gggagctttt 857521 gtccccatta tgacggggaa aaggatcgga gaccggcata ccaccagctg atatctaaca 857581 agttcttatg cagtggctat gcagcggatg atggggctgc tctccatttc ataaatgatc 857641 agctgtttca gactgtgagt tcaaggtcgg gtgcaaaggc atatcgggtg atgatggctg 857701 aacatgaaat agctgaaatc ccgttgccgg tcaaatattt agggtgaaat tggctgaata 857761 ttatctatat tcctcttttt ttcagattga ttttatgata agatgagtgc gaaatcaata 857821 gttactgggg gtgcccgctt tcgggctgag agagaaggca agcttcttaa ccctttggac 857881 ctgatctggt tcgtaccagc gtggggaagt agaggaattg tttttgttat tgtcttgctg 857941 ggcaataata tgtttctttc tgactgtaac cgggttcatt tatatgaatc cggttttttg 858001 tgctggttat gggcttgatt ttgtcctttc aaacgtagaa aggggaagga aaagtaatgc 858061 aaaacaattc agtgcagcaa gccaacattt ccattatgtc aagtttttca ggcagcaaga 858121 aggtatacgt ggagggttct tcttcggaca tccaagtgcc gatgagggag attgcattga 858181 gtccgacgac gggatcgttc ggcgaagagg aaaacgcgcc tgtgcgtgtc tatgatacaa 858241 gcggaccgta tacggaccct gaagtaacca ttaatattca agaaggatta aagccgctcc 858301 gccaaaaatg gatcacagag cgcggtgacg tggaagagta tgaaggtcgg gctataaaac 858361 cagaagataa cggttataaa aaagcaaaac caaacgtaag ctatccagga ttaaagcgga 858421 aaccgctgag ggcgaaggca ggtcaaaatg tcacacaaat gcactatgca aaaaagggga 858481 tcattacacc tgagatggaa tttatcgcca ttcgtgagca tgtgtctcct gaattcgtca 858541 gagacgaggt agccagcggc cgggcgatta ttccttcaaa cattaatcac cctgaaagtg 858601 agccaatgat tatcggccgg aattttcatg tgaagattaa tgcaaatatc gggaattcag 858661 cggttacgtc atccattgaa gaagaagtgg aaaaaatgac gtgggccatc cgctggggag 858721 cggatacgat gatggatctc tctaccggaa aagatattca tacgacgcgt gaatggatta 858781 tccgcaattg ccccgtgcct gtgggaactg ttccgattta tcaggcgctt gaaaaagtaa 858841 acggcgtagc tgaggattta acgtgggaga tttatcgtga tacgctaatc gagcaggcag 858901 agcagggagt ggattatttt acgattcacg cgggtgtttt gcttaggtat gtaccgctga 858961 ctgccaaacg gacaactggt atcgtgtcac gcgggggagc gattatggcg cagtggtgtc 859021 tggctcatca tcaagaaagc tttttataca cacattttga agaaatatgt gagattatga 859081 aaatgtatga tattgctttc tctcttgggg atggtttgcg tcccggatca attgctgatg 859141 ccaatgacga agcgcagttt gctgaattag agacgcttgg agagctgacg caaattgcct 859201 ggaagcatga tgttcaggtg atgattgagg gtcctggaca tgttccgatg cataaaatca 859261 aagagaacgt cgataaacaa atggacattt gtaaagaagc gcctttttac acattggggc 859321 cgttgacaac ggatattgct ccgggatatg accatattac ttcagcgatc ggagcggcga 859381 tgatcggttg gtacgggaca gcaatgcttt gttatgtaac gccgaaggag catttggggc 859441 tgccaaaccg tgatgatgtt cgtgaaggag tcattacata taagatcgct gcgcacgctg 859501 cggaccttgc aaaagggcat cccggagcgc aaatccggga tgatgcgtta tcgaaagccc 859561 gttttgaatt ccgctggcgg gatcagttta atttatctct tgatccggag agagcccttg 859621 aataccatga tgaaaccctg cctgctgaag gagcaaaaac cgctcacttt tgttccatgt 859681 gcggtccgaa attttgcagc atgagaattt cacaggatat tcgggattat gcgaagaaaa 859741 acgatctcag tgaagcagaa gccataaata aaggattaaa agaaaaagca aaagagtttg 859801 tcgatacggg aagcaattta tatcaataaa aaaaatgaag atggagaatg ctccatcttc 859861 atttttttag aaaaacagag agcgtcgaag cggaggaata ctctgttcaa agcggaaaac 859921 attttctgga tcatatgtcg ttttgacacg gcggagtcgt tcaacgtttt cgccgtaata 859981 tgttcttggc cagtttctga tttcgatatc tggccaattt acgtagtctc ccatcgtttc 860041 tttcgaaagg gacgttctca gcccctcaat ccagcggaca ttttgtcttt tttctccagg 860101 ggatgtccag tttgttaagt attcctgggc gatgattgcg tcacgataat aaaatgccgt 860161 ttggtcggga gcgacccgtc cggctgcccc gccgagtgct tgctgccaga cactggcgtt 860221 ttgattcgga gcgtgctcta aaaagtgttt tattgttgag atcgcacgtt ctgataatgg 860281 cttttcaatg aaagagccgg agcgtttcat tttttgaggc tgattgcctc ccgggctgtt 860341 aaaaaaggtt accgcttcaa tgaatggcgt tgtttttacc attccgcttg tcggacttcc 860401 tgctttcaat aaaggcttta acagtttttt taactctgtt tttggcccga caaattggcc 860461 gagggcttct atgcggttta cttctttagg ccaaaactct attgatgatg taagccggtc 860521 atctgtatac ggggcccagt tctgccacgt gttatatact tcctcaaaat catcccatcc 860581 ccatgtaata gaaaaaatcg acacttgaga gatgggcact gctttaaatg tcatggaggt 860641 gactatgccg aaattgcctc ctccgcctcc ctgagacgcc caaaataagt ctggatgatt 860701 tgaacagctg actgtaatca gatcagcgcc ctctttttcg tctgctacga tcatctcaag 860761 ctgcacgagg ctgtcgcaag taagaccggc agcccttgtt aaaagtccaa ttccccctcc 860821 gagagttaaa cctgtgagcc ctacattagc aatggtgcct gcgggaagcg tcaggccgta 860881 ttgccagagt gtccgataga cttctcccaa ttcagccccc gcttcaatat aggccagctt 860941 tttatcctga ttcacagtta tttttttcat ctcgcttaaa tcaataacaa gaccgttatt 861001 taaaagggaa aagttctcat agctgtgtct gccgcctcta atacggaaag gcacacggtt 861061 ttcacgcgcc catttcagcg cattgagtgc atcctgtttg ttttggcaaa acacaatgat 861121 gtcaggatac ctttctaagc ttaggttaat attggttctt gcttcgttat agtccggatc 861181 atcccgtgtc acgatacgtc cggtcaattt tgtcttttcc acactcccac atctctttct 861241 ctcgtattct agtttctcta gcttatgcgt caggggaaaa gagtgtataa ggaaaaagcg 861301 gggatgcaat ctgatacagt gtcaacaccc tcaaaaaata gttgacaggt cggtattgta 861361 tgaattaaca tggtcagtac aaatttttca aatttatcgc gctgatcgga acaccgaagg 861421 ctcttatcgt ttagataagg gccttttttg tatgaaaaag gggggattat tgatgggagt 861481 caaaaaagaa aaggggagaa aacgattcag gaagcgaaaa acctacggga atcagatttt 861541 gccgcttgag ctgctgattg aaaaaaacaa acgagagatt ataaacagcg cggaactcat 861601 ggaagaaatt tatatgaaga ttgatgagaa gcatacgcaa tgtgtaacta aatataaaaa 861661 aacccgctga ctacaacggg tttttgcatt tctccattaa gaatcttttt taatcggcaa 861721 tccaaggcct tctgccacgc gttttccgta ttcaggatcc gctttgtaga agtgctcgat 861781 ttggcgcagc ttgatttctt ctttttctac cggcttcatg gcattaacga tattttcaac 861841 aaggcgggta cgttcatctt cactcattaa acgatacaga tcgccggctt gagtgtagtg 861901 atcgtagtga tcgtagctta cgctgtcagc gataccttgt accggatatg ctgcttgctt 861961 atcctcaggt gactcttttg gaccgccgaa gctgttaggc tcgtaataca cagatccgcc 862021 gccgttatca tcaaaacgca tttgcccatc acgctgataa ttgtttactt tgttgcgtgc 862081 gcggttgatt ggcagcgctt gatggtttgc accgacacgg tagcggtgtg catcatgata 862141 agcaaaaagt cgaccttgaa gcattttatc cggtgaaaca tcaataccag gcacgagggt 862201 tccaggtgaa aatgtcgctt gttctacctc tgcaaagtag ttttccggat ttctgtctag 862261 aaccatgcgt ccgacctcga ttaacgggta gtctttttga gaccaaactt ttgtgacatc 862321 aaacggatcg aaacggtacg tatttgcatc ttctaaaggc atgatttgca catatagttt 862381 ccatgcagga taatcaccgt tttcgattgc gttgaaaagg tcttctgtat ggtaatcagg 862441 gttttcaccg gcaatttttg ctgccgtatt gacatcaagg tttttcacgc cttgttctgt 862501 tttaaagtga tatttaatcc atacgccttc gccttcggca tttgtccatt tgaatgtatg 862561 gcttccgaag ccgtgcatgt ggcgaagtgt cgcaggaatt ccgcggtcag acatcaggat 862621 tgtcacttgg tgcagtgact ctggtgaaag tgaccagaaa tcccatacag ccgtagggtt 862681 tttcaggtgt gtttttggat ctcttttttg tgtatggatg aaatcaggga acttaatcgc 862741 atcgcggata aagaatacag gcgtattgtt gccgacgatg tcgtagtttc cttcttcagt 862801 ataaaattta acagcaaatc cgcgcgggtc gcgaactgtg tcagcagagc caagttcacc 862861 ggcaactgtt gagaaacgga tgaacaacgg tgtgcgtttg ccgacttcag aaaggaaagc 862921 ggctttcgtg tattttgtta cgtcgtttgt cacttcaaaa tatccgtgtg cgcctgctcc 862981 tttggcgtga acaacacgtt caggaacacg ttctcggttg aaatgggcca atttttcgag 863041 taaatgtaca tcttgaatta aagttggtcc gcgagaaccg gcagtcattg agttttgatt 863101 atctccaacc ggagcgcccc agctagttgt cagtttattt gaactcatgt tatcacctct 863161 tggaatttat aagaacataa tatcatctct aagtaaaaag tcaatattat tttataatta 863221 ttataaaata gttatctcta ttaatcgata tatagtatcg aaattgttga aaaaccttgt 863281 tgtaacagct ttttatgaca cttaataatt tttggagaaa taatttttcc ttctctattt 863341 gcgaaacaag cagagtaagt gataaacaag gatatcaaaa atcgtattta aaaaagagtt 863401 gacatatcgg aataatttga attaacatgt tattcaaaca aaaaaacaat tgggcagctg 863461 atcggaccgc cgaaggctct catctctaca agaacagaga tgggggcctt tttgtttttt 863521 ttgaaggcgg ggttggcaga aagagaggga taaaagtggc tgtgaccatc agcatcaaag 863581 aaaaggcatt tgttcaagaa ggccgcaaaa acacggtctt agaaaacata gaattatcaa 863641 tcgcaccagg cgaatttcta acgcttatcg gaccgagcgg gtgcggaaaa agcaccctgt 863701 taaagattat tgcagggctt gattctgaat atgacgggag tgtggaaatt aacggccgca 863761 gcgtaacagc tccgggtatt cagcaaggat ttatttttca ggaacaccgc ctctttcctt 863821 ggctgactgt tgagcagaat attgcagccg acttgaattt gaaggaccca aaagtcaaac 863881 aaaaggtgga tgaactgatc gagattgtca gattgaaagg atcggaaaaa gcatatccgc 863941 gcgagctgtc aggcggcatg tcacaaagag tagccatcgc ccgggccctg ctgcgggagc 864001 ctgaggtgct gcttttagat gaaccgtttg gtgcactcga cgcttttaca agaaaacacc 864061 tgcaggacgt gctgctggat atatggagga agaaaaaaac aacgatgatt ctcgtgactc 864121 atgatataga tgaatctgtt tatttaggaa atgagcttgc gatccttaag gccaaaccgg 864181 ggaaaatcca taagctgatg cccattcacc tggcgtatcc gcgaaaccgg acgactccgg 864241 atttccaagc gatcagacag agagtgctgt cggaattcga gaaaacagaa gatttggagt 864301 acgcagaagg atcagggata tagaaagggc ggaagcggaa atgaaaaaag gactcattgt 864361 attggttgcc gttatttttc tgctcgcagg ctgtggagca aatggagcca gcggtgacca 864421 caaacaattg aaggaaattc gtattggtat tcagcaaagc ttaagccccc ttttgattgc 864481 aaaagaaaaa ggctggttcg aagatgcatt tgaaaaagaa ggcatcaaag tgaaatgggt 864541 ggagtttcaa agcggtccgc cccaatttga aggccttgcg gcagacaaac ttgatttttc 864601 tcaagtcggt aattcgcctg tgatcgctgg acaggcggca ggcattgact ttaaagaaat 864661 cggtttgtct caggacggct tgaaagcaaa cggcatcctt gtcaatcaaa acagcggcat 864721 tcaagacgtt aagggcttaa aggggaagaa aattgcagtc gccaaaggca gcagcgggtt 864781 tgattttttg tataaagcgc ttgatcaagt ggggttgtca gctaacgatg tgacaattat 864841 tcagcttcag cctgatgaag cagcttccgc atttgaaaac ggatctgttg atgcctggtc 864901 catttgggag ccgtacttgt ccttagaaac aatgaaacac ggagcaaaaa tccttgtgaa 864961 cggagaaagc acagatttat attcaccggg ttttacttta gtaagaacaa agttttcaga 865021 agagcatcca gacgaagtgg tccgttttct gaaggtgttt aataaagccg ttgtatggca 865081 aaaggaacat ctggatgaag cagcggactt atattctgac attaaagatc tcgataaaaa 865141 ggtcgtcgaa aatgtgctga aaaatactga gccacttaat gagatcatca gtgacgacat 865201 tgtgaaagca cagcaggaaa cagcagattt tcaatttcga acaaaggcga tagataagaa 865261 gattgatgtg aaggatgttg tcgataacac ttttatcaaa aaagcattag aggagcattc 865321 ctcaggaggt gatcaatgat gaaagcagag gctgcgggct cgctgcccaa aacgaatgcg 865381 gaagcggtgc gaaaaaagcc cggaaggaag agatacggct ggatgaaggg gcttttactg 865441 cccgctgtca tcattgccat ctggcaggtc atcggcgggc tgggggttgt gtccgctaca 865501 gtgctgccta cacctgttac gattgttctg acctttaagg agcttatttt gtccggcgaa 865561 ctgttcggcc atctgcaaat cagcatttat cgggcggcac ttggtttttt gcttggcgcg 865621 gggcttggat tgatgatcgg gattttggcc ggattttcca aacggacgga gctgtatctt 865681 gatccgtcgt tgcaaatgct tagaaccgta cctcatctgg ccgtcacgcc gctgtttatt 865741 ttatggttcg gatttgacga agtatctaaa attttgctga ttgcgctcgg tgccttcttt 865801 cctgtctata tcaatacgtt taacggcatc cgcggggttg acgcgaagct gtttgaagtc 865861 gcccgggtgc ttgaatttaa atggcatcag cagatatcca aagtgatatt gccggcagcc 865921 ctgcccaata tattgctagg cattcgctta tcgctcggca ttgcatggct cgggctcgtt 865981 gtggcagagc tgatgggctc aagctcggga gtcggctata tgatcatgga tgcgagacag 866041 ttttcacaaa cgaataaagt ctttgcaggg attatcattt ttgcagtggt tggaaagctg 866101 acggattcct tcgtcaggct gcttgaacga aagctgttaa agtggagaaa cagctacgaa 866161 ggataaaaga tataaagggg agatgaatat ggaaattctt tggtttatac cgactcatgg 866221 agacgcgaga tatttaggat ctgaaagtga tggacggact gcggatcatc tttactttaa 866281 acaagtcgcg caggcggcag acaggctggg atatacagga gttcttctgc caacgggaag 866341 atcgtgcgag gacccgtggc ttacagcgtc ggcactggca ggagaaacaa aggacttaaa 866401 gtttttagtc gcggtaagac ctggtttaat gcagccttct ctggcagcca gaatgacatc 866461 caccctagac cgcatttcag acggccggct gctgatcaac gttgtggcag ggggcgatcc 866521 gtatgagctg gcaggcgatg gcctgtttat cagccatgat gagcgctacg aggcaacaga 866581 cgaattttta accgtttggc ggagactttt gcagggagaa acggtttcct atgaaggaaa 866641 gcatataaaa gtggaaaaca gcaatctgct tttcccgccg cagcaagagc cgcatccgcc 866701 catctatttc ggtggttcgt cacaggctgg aattgaagct gccgcaaagc atacagacgt 866761 gtacttgaca tggggtgagc cgcctgaaca agtaaaagaa aagatagaaa gagtcaaaaa 866821 gcaagcggca aaagaaggga gatccgttcg atttggcatt aggctgcatg tcattgcccg 866881 tgaaactgaa caagaggcat gggaagcggc agagcgcttg atcagccact tggatgatga 866941 caccattgcc aaagcgcagg cagctttgag ccgttacgac tcttcaggcc agcagcggat 867001 ggccgtcctt catcaaggcg atcggacgaa gcttgaaatc agcccgaatc tgtgggcggg 867061 gatcggcctg gtcagaggag gggcaggaac agctcttgtc ggtgatccgc agacgattgc 867121 cgaccggata gcggagtacc aggcactcgg catagaatcg tttatattct ccggctatcc 867181 gcatttagaa gaagcgtatt attttgcaga gcttgtattt ccgcttttgc cgtttgaaaa 867241 tgatcggacg agaaagcttc agaacaaaag gggagaagcg gtaggaaaca cttattttgt 867301 caaagagaaa aatgcatgag tttaactaaa atacagcccc ccgaacatgg tatgatattc 867361 aaaaaaaggg ggcttttttt ctgaaaacat tgagaagcgc ggcagtcatt tgcctcatag 867421 ctatgctgtc agcatgcgga cattcaaaac agatggaaat caaagcggcg gacatatcag 867481 atcttgaaaa aaacagaatg gatgtcgcag cttcacaggc attcactgcc gaagccgtca 867541 atatcggtga aggtatttct tcagctgaca tgtacatcga acattatcaa aagggaaagc 867601 ttgttgagag gtttggaccg gttcgtgcag attattcaga ggaaaaaact gataccatac 867661 aatttgttta ttttgagaat gaagaggggg aaggaaagaa taaacatacc accattcatt 867721 ttggcattgt ggataaacag ggaactatag cggctgattc atcggtgaaa cgcgacgata 867781 gcacaacaca ggaaatgact cagaatattt catcgccgga accgattact ttcgagaagc 867841 ctgctttgat cggcagcagt attagaggga ctgacgagac aatgcacacc tctgaacata 867901 aaaaagagct cattaagcat caagatgcgt tactgtatta tgtggaattg catcattaga 867961 atgggcggct tcaggccgtc tgttttacaa agcggtatgc ttgctttttt gaatggtgaa 868021 tgatacattt taaatcgtaa caatttcgat ttaaagggag gctatgtgac ttggctaaaa 868081 aatcaaaagt ggcaaaagag ttaaaacgcc aacagcttgt tgagcaatac gctggtatta 868141 gacgcgagtt gaaggaaaaa ggagattacg aggcactcag caagctgcca agagattcag 868201 caccgggaag gcttcacaac cgctgcatgg taacggggcg cccgagagca tatatgagga 868261 agtttaaaat gtccagaatc gctttcaggg agctggccca taaaggccag attcccggtg 868321 tgaaaaaagc aagctggtaa gaaaaaactc cggccgatta cagcgcgccg gagttttttt 868381 cgtttttctt gaaagagatg acgtaggaaa ggtgctggat gatcatgatg ataaacacaa 868441 taataatagg gaaaaacgga atgcgcgatt gaaatagcgg ataaaaaatg agaagaaccg 868501 ctgcggcagg cagcgagaag tagacagcga tatatgacgc gcgacatgct tttgccgtca 868561 tcatctgctc tctttcatcc tgctcttcaa actcatcagg cagaagtagc tgctttctgg 868621 cagggcggct ttttttctgt aagtacaaat aaaccgcaga cgccgcaaca aacagaataa 868681 agggagtgag gtttaaatca aataccatcc cgccgctctt tgtgccgaaa aaagatgcta 868741 tgccttctga ggcttcaaag tatgaaatca gcgcccagca tgcaaggcca aataaaacaa 868801 ggtgaaaagc tgcttttgtt ttcatgctca tcttagtttt cctcctctaa ccaaaagaca 868861 tcctccattt tcatggagaa ggctttgcag attttcagtg ctaacagcag tgagggaaca 868921 taatcgcctt tttcaatcgc tgccacagtc tgtcttgtga cgccgaccgt ttctccgagt 868981 ttttcctgag aatagccgaa gcgtgccctc agctctttta ctttattttt catcatgacg 869041 tctgtcccct tcacaatctc gattgattat attgtatagt atacttaaca ttatgtaaat 869101 ggaacttaac aactttacaa aaagataact ttttttcgac aaaattttta tattcccttg 869161 acgaaaaata aataaacatg taatataaaa aaagtcagag cggtactgtt gctgacaatc 869221 acaaatgcgg gtgtagttta gtggtaaaac ctcagccttc caagctgatg tcgtgagttc 869281 gattctcatc acccgctcca tacatacgtt attaacgcag tgtttcgttt ctcagataaa 869341 cgaagtattg cgttttttta tgtgaaaaag aacacggtat tcgtgttctt ttacgtaagc 869401 caatgtactg tatgggtgcc gccgtgaatt tgttcaaaca ttttcgttaa tgatgataag 869461 aggttaacag cgctgctttt ctcaatcgat ggcgggaaaa aaatgatttg cagcatattc 869521 ttagtctcgt ttgaaacggg atagtggttg acgctgtttt tgaaatcgcc aaaaatgccg 869581 ttttcatcag agaaaagcag tatgttttct ttttctccca atgagatccg gaccggctca 869641 tgaagctttc cggcatcata aatcataata ggcagagaat attttaatgc gaaaaaatcg 869701 attgtgtcat gggccgagtc tttactttcc atgaattgtt ccttggatat cgggaccagc 869761 atgtcctcca ttggggttgt ttctccctca aatgaagggt taagctgttt aaagagtttc 869821 tgccattcct tgacgaagga ttcatcggat ataccgccgt ccgcatagtc gaaaaacaag 869881 gattcttgaa acaggcggag tctgcctttc agcatttgcg gtgaggagcc gacttcgata 869941 ttctcataaa tgacagcagc tgcatgtaag ccggccgcac gttcagtaat aacagaatca 870001 agtttgatat tcactagcat tcactccagt tacgtgatat caacctatta taaacgctgt 870061 gtcgttttat cacaaagaaa ggaggctgtg caaaacatga acgtttatca gctcaaagaa 870121 gaattaattg aatacgcgaa aagcattggc gtagacaaga ttggttttac gaccgctgat 870181 acttttgaca gtttaaaaga ccgtttgatt cttcaagaat cactcggcta tctctccggc 870241 tttgaagagc cagatatcga aaaaagggtg acgccgaagc ttcttttgcc gaaagcgaaa 870301 tcaatagtgg caattgctct cgcatatcct tccagaatga aggatgcgcc gagaagcacg 870361 agaactgagc gcaggggcat tttttgcaga gcttcctggg gaaaagacta tcatgatgtg 870421 ctgagggaaa agcttgatct gctggaggat tttctaaaaa gcaagcatga ggatatcaga 870481 acgaagtcaa tggttgatac aggtgaattg tctgatcgcg ccgttgcgga acgtgccgga 870541 atcggattca gtgcgaaaaa ctgtatgatc acaacacccg agtatggctc ttatgtgtat 870601 ttggcggaaa tgatcacaaa tatccctttt gagcctgatg tgccgattga agatatgtgc 870661 gggtcctgca cgaaatgctt ggacgcctgc ccaacgggag cactggttaa tcccgggcag 870721 cttaatgcgc agcgctgcat ctcttttctg acccagacaa aaggattttt gcctgatgaa 870781 ttccggacaa aaatcggaaa ccgcctgtac gggtgcgata cgtgccaaac ggtatgccct 870841 ctcaataaag ggaaggattt tcatcttcat ccggaaatgg agcctgatcc tgagattgcc 870901 aaaccgttat tgaagccgct tttggccatc agcaatcggg aatttaagga gaaattcggg 870961 catgtctcag gttcttggcg cggaaaaaaa ccgattcagc gaaacgccat tctcgcgctt 871021 gcccatttta aggatgcttc cgcactgcct gaattgacgg aactgatgca caaggatccg 871081 cgtcctgtca tcagggggac agccgcatgg gcaatcggaa aaatcggaga ccccgcctac 871141 gcggaagagc ttgaaaaagc gctggaaaaa gagaaggatg aagaggcaaa gctggaaatt 871201 gaaaaaggaa ttgagttgct aaaagcttca ggcatgacta aacaaggcct gtcctgacat 871261 acgtatagag cagaaggaaa aaacacttga gatcatccaa gtgttttttc tctataaaaa 871321 agtatggcgg gtggggtgag cttgaagtac attttagaac aattagcgga ggagcggctg 871381 ggctttctgg ttaacgggca tgctatgaga caggagtctc aagtcggaga ccttaaagtc 871441 atggagcgta agaaaaagct tctggaaaaa cgtaaagttg acatcataaa agcgaaagca 871501 aaggccgtga ttaatcatgt gcgggttgag gatgacggaa cgacctgcct ttcgtatacc 871561 atccattacg aatacgtgtg taaggaacaa gatgacagct tgtatataga agagcacata 871621 gaggagcgaa tggctttcct gtatgatcac attttgatta gtgatcagga aattgcgaaa 871681 aagccggctg gatttcatga agggaccagt attattgact attctgaagc tgaagaggaa 871741 agagaagcgt ttggcagggc ttttcaatac gatcgtctcg gcgctgtcca atatgccgag 871801 aaattttgga acaagcgcaa tcctgcttat aaaaatttca gcgataactg tacaaatttt 871861 atttctcagt gtcttcatgc aggaggcgcg ccgatgcgcg gtcatccgaa caggggatca 871921 ggctggtgga tgaaacaaag ctcatggagc tacagctgga cggtggctca ctctatgaaa 871981 atgtatttgt cgaattcaaa ggccggactg cgtgcggtgc gggtgaaatc agcggaagaa 872041 ctgatgccgg gcgatgtgat ttgctatgac ttcgaaggag acggccggtt taatcataca 872101 acgattgtcg tggcaaagga caaaggcaat atgccgcttg tcaacgccca gacttatgac 872161 agcaggatga ggtattggtc atatgaggat tctacggcat acacgccgtc aatacgatat 872221 gccttttttc atatcgttga tgatacgaca aaagagtaat taatgttata atgatgggcg 872281 gataagaaaa acagaggtga acattgtggc attacatgtc gttttatatc aaccagaaat 872341 tcccgctaac acagggaata ttgcacgtac ttgtgcagca accaatacaa cgctacacct 872401 gattcgtccg ctcggctttt caacggatga taaaatgctg aagcgtgccg gactcgatta 872461 ttgggagttt gttaacgttg tgtatcatga ttcgttagaa gaattgtttg aggcatataa 872521 aaaaggcaag tttttcttta ttacaaaatt tggccagcag cctcatacat catttgatta 872581 cactgatctt gacgaggatt atttcttcgt gttcggaaga gaaacaagcg gtttgccaaa 872641 ggatttaatt caaaataata tggaccgctg cctgcgtctt ccgatgacag agcatgtcag 872701 atcgttaaat ctgtccaata ctgccgcgat tcttgtttat gaagcgctgc gccagcaaaa 872761 ttaccgtgat ttaaaatagt gaaaaacccg ctcatcgatg atgggcgggt ttttttgcgg 872821 atgttgaaat gctttgtttc gtttttgggc ttaacaacgt aacagtgtta tgttacaatg 872881 tacccatcaa aggagctgga cttatggaag aacaattaat ctctaaaaaa gaattacttg 872941 aaagaacatc gatttcatac ggtcagctgt atcgatggaa gcggaaaaac ttaatacctg 873001 aggaatggtt tattcgtaaa tccacattta cagggcaaga gacgtttttt ccgagagagg 873061 agattttaaa acgtatatca atgattcaaa agatgaaaga aaatttgtct ttggatgaaa 873121 tgagggaaat gctgtcgccg aaaatgaagg atgtcagcat gaccgctgat gaattgcttc 873181 ataaaggttt ggtttcaagg cctgctcttg aagcctattc agaagacgga ggaagtccgg 873241 ttttttcatc cagcgatttg ctttcgctgt ttgtgcttga gggcctgctg cagtctggaa 873301 atgtcagcct tgcagaagca aaaatggctg cagaggtatt aaagaagcat gatactgaag 873361 agattgaaaa acagacggag ctgattgtgc tccgcaagct cggtgtcaca acttgtttta 873421 tagcggctgc ggcggacagc attttgtttg aatcatccgt aaaggttgtg gaacgggtag 873481 atttattaaa agcttcagag gaattaaaaa caacatttat gcaggagggc catcaatgga 873541 tgtagtggaa aagctggtga taaatggatc aggaagttct aagggaggaa catttcaatc 873601 agttgagatt aatggcagcg ggacagtggc cggggacgtg gagtgtgaca ctttttcttt 873661 taatggaaac ggaaaagcgg acggcagcgt caaagcgaaa gcggtaacta tcagcggttc 873721 aggaaagata catggagacg ttgaagcaga atctatccgg atgaatggca ctggttttat 873781 tcaaggagag gtatctgcaa aacaattgaa aatcgctgga tcatcaacat ttggcggcac 873841 tgtcaaggct gatggaattg acattagcgg aaaagctgtc atggaagcag attgtgaaac 873901 agaaaccttt caatcagaag ggaaatgcaa aatcagcggg cttttaaatg cagaccaggt 873961 gatcattaag ctttctgcag gggaaagcta tgcgcgggag atcggctgcc gccatcttca 874021 agtgacctgc agaaaaggaa tgctgacatt gctcagattg atgccgcagc ctgttctaac 874081 agcagagctg atcgaaggtg acgtgattga attgacaaat acaaaggcga aaaccgtgcg 874141 cggtaataaa gtgatcatcg gcccggattg ccagattgaa accgtcgaat acagcgggga 874201 ctatacctgt gatccaagcg cgtcggttga aacatccaca aagttgtaag gaggatcgta 874261 atggagacaa caaaactggg aaatttaaaa ttatatggcg ctgggcatgc cgcaggaggc 874321 gcgtatcaca atgtcagcat caaaggagaa ggtatagttg gagaagggct gtctgctgta 874381 ggctgccgca tatacggaac gggccttttt ctcggaaaag cagagactga gcggctgcgt 874441 gtgctcggag aaagtgaatg taaaggcgat ctgacagccg gcaaaatcaa tatatatggg 874501 acaatgaaag tcagcggctc acttcaattt gatcgattca atctgaaagg ccagactgaa 874561 attggcggga atatgactgg agaatcctgc gatgtgaaag ggaagcttag cgtaataggt 874621 gattgtgaaa cagaaatgtt ccatgtcaca ggctgtgttg atgtatcggg gttattaaat 874681 tcgggtgaga tcaagctggg attgagccat gatataagcc atgtgcagga aatcggcgga 874741 acaacaatta cagtgaaaag acgcgcgagt ttttttagcc ggaagaaagg gaagctgatc 874801 gccgatgtca tagaaggaga tcgggtttat ttggagaata ccgaagcggc agttgtcagg 874861 ggaaaagaag tgatcatcgg gccgggatgc agcatcggaa cgattgagta cgaatacaaa 874921 tgtgaatgcg atccgcattc acagattaaa gaaaaaacaa aactgtaaaa cattgttctg 874981 ttatacaaaa agggtgctct ttcaggagca ccctttttta ttcttttcca ggcttgcttt 875041 cgtatcctgc ggtaaaaatt gatactaaaa aagtgacaat gacacccatc atgatgattg 875101 ttttcaccgt ctctccccct cttcaatttt tccgtgctgt ccgagtctgg atgattctgt 875161 atttttcttt attatgaacg gtcgcagtct gccttgtcaa cgatgtatga gtatctttat 875221 ttttaagaaa ccaaagcatg tatcacgaga tggcggcata gattgtatca aagtacctta 875281 tttgcatagt gtatcaaaca tgatagagga ggtccttatg gatatattaa agaaaattga 875341 aaagtacaga gaggaagagc agcggctgaa atgggaagga actttcgccg attatttgga 875401 gattattaaa gaaaatccga tggtcgcgca atctgctcat tctcgagttt ttaatatgat 875461 aaaagacagc gggatagagg agattgacgg acgcaagaag tacagttttt ttgaccgcga 875521 gctgttcggg cttgaagaat ctctggagcg tcttgtggaa gagtattttc atccggctgc 875581 caaacgtcta gatgtcagaa agcggattct attgctgatg gggcctgtga gcggcggtaa 875641 atccacgctg gtcacaatgc ttaaaaaagg tctcgaagcg tacacgctga cagataatgg 875701 cgctgtatat gcgattaaag gctgcccgat gcacgaggac cctctacatt taatccccca 875761 tcatttacgc gatgactttt acagagaata cggcattaga atagaaggaa gtctttctcc 875821 tttaaatgtc atgaggctgg aggaagagta cggaggaaga attgaggatg tgaaggtgga 875881 gcgcatcttc ttttcagaag ataagcgtac gggaattgga acattcagtc cctctgatcc 875941 gaaatctcag gatattgccg atttgacggg gagtattgat ttctcaacaa tcgccgagta 876001 cggttcagaa tcagatccgc gcgcttatcg atttgacgga gagctgaata aagcgaaccg 876061 cgggatgatg gagtttcagg agatgctgaa atgtgatgag aaatttctct ggcatttgct 876121 ttccttgaca caggaaggga attttaaagc tgggcggttt gcgttaattt ctgctgatga 876181 gctgatcgtg gctcacacga atgaaacgga gtatcgctca tttatttcta ataagaagaa 876241 tgaagccctg cactcaagaa tcatcgtgat gccggttcct tataatttaa aagtgtctga 876301 ggaagagaga atttatgaaa aaatgattgc agaaagcgat gtggcggatg ttcatattgc 876361 cccgcatacg ttgaaggtcg ccgcgatgtt ctcaatcctt acccggttaa aagagccgaa 876421 gcggtcggat attgatctgg tcaagaaaat gagactgtat gatggggaaa gtgtggaagg 876481 atataactct gtcgacgttg aggatatgaa aaaagaatat aatgatgaag gcatgagcgg 876541 aattgatccg cggtacgtga tcaaccggat ttcttcaacg attatcagaa aaaatatgga 876601 atcgattaat tctctcgatg tccttcgctc cttaaaagaa ggtcttgatc agcacccatc 876661 aatttcaagc gaggacaggg agcggtattt gaattttatc tctgccgccc gcaaggaata 876721 tgacgatatt gcgaaaaagg aagttcaaaa agcgtttgtt tattcatatg aagaatcagc 876781 aaaaacactt atggacaatt acctcgataa cgtagaggcc tattgcaata aaaacaagct 876841 tcgtgatcct ttgacaggag aggaaatgaa ccctgacgaa aagctgatga gatccatcga 876901 agagcagatc ggcatttcgg aaaacgccaa aaaagcgttc cgcgaagaaa ttttaatccg 876961 catctcggcc tatgcgagaa aaggcaagcg gtttgattac aattcccatg aaagactgcg 877021 tgaagctatt cagaaaaagc tgtttgctga tctgaaggat gtcgttaaaa ttacgacctc 877081 aacaaaaacg ccggatgagc agcagctgaa aaaggtaaat gaagtcgtgg cccgtttaat 877141 tgatgagcac ggctacaact cgacgagcgc caatgagctg ctgaaatatg tcggcagcct 877201 gctgaaccga taagcaacgt gacccgtccg aatagggcgg gttattttgt cccattttct 877261 aaatagtttg tcaattaaac gtgcatatgt gcatatgatg aatataaatc ttttcaaaag 877321 acttgtttca taatctggca caagccggaa tacgtatgta tcacgaccac aaatggttaa 877381 ggaggggaat tcatgtccca aaatgacagc ggccattttt tgatttctga ggaaaactgg 877441 tccctccatc gcaaaggctt cgatgaccag cagcgccacc agaaaaaagt gcaggaagcg 877501 atcaaaaaca atcttccgga cctcgtaact gaggaaagca ttattatgtc taatggaaaa 877561 gatgtagtga agatcccaat ccgttcactt gatgagtata aaatccgtta taactatgat 877621 aaaaataaac atgtagggca aggagacggc gagagccagg ttggagatgt tgtggcccgg 877681 gatggatcag acaaaaaaca agggcctgga aaagggcagg gtgccggtga tcaggcaggc 877741 gaggattatt atgaagcgga agtttcatta atggatttag aagaagcgct ttttaaagaa 877801 ttagagcttc cgaatctcca gcaaaaagag cgggacaata tcattcatac agatatcgag 877861 tttaatgata tccgtaaaac agggttaacc ggtaatattg ataagaaaag aacgatgatg 877921 tcagccttta aacgaaacgc aatgtcagga aaaccgtcgt tctacccaat ttatccggag 877981 gacctgaaat ataagacgtg gaatgacatc acaaagcccg aatcaaaagc cgtcgtttta 878041 gccatgatgg atacaagcgg cagtatgggg gtttgggaaa aatacatggc cagaagcttc 878101 tttttctgga tgacccgttt tttgcggaca aaatacgaga ctgtggaaat tgaatttatt 878161 gcccatcata cagaagcaag agtggtctcg gaggaggatt ttttctcaaa gggagaaagc 878221 ggcggaacaa tttgttcttc cgtatatcgg aagtcgcttg agcttattga tgaaaagtac 878281 aatcccgccc gctataacat ttacccgttt catttttctg acggtgacaa cctgacatct 878341 gataacgcgc gctgtgtgaa gctggtcaat gatattatga agaaggccaa tctgttttgc 878401 tacggcgagg tcaatcagta caacaggcat tcaacgttaa tgtctgcata taaaaatgta 878461 aaagatgaga aatttaagta ctatatttta aaacagaaat ctgatgtttt tcaggctcta 878521 aagaactttt tcagaaatga agagtctggt gtaagccatc aattttcgta atgaaaagcc 878581 catttcaggg ctttttttta tttaataaaa gcaagaaaac gcttgcgaaa aaaatacggg 878641 agaaaaagaa atttttcctt tgacaaatct tctttcattt attaatattt tatcttgtga 878701 actattattg aggaatgagg tgaaaaggag ttgactgaat cagaacgtgc tttgctcact 878761 tttgaacagc tcttcgatac gtctcgggcg atatataaaa aacagaagaa gatattggag 878821 attgtgcttg agccttttga tattacagtc cttcaatatt tgctgatgtt taaaattcat 878881 caaagcggaa gcaccccgct aagcaagctg gcaatgtcgc ttgatcttaa gcctgcttct 878941 gtgacgcgga tgacagatat tctgtataag cgccaattga tgaatcgata tgacagtccg 879001 gatgaccgcc gtatcgtcat gattcagtta accgaagagg gggaagaact gatagaaaaa 879061 gccgctgtgc aatatgcaaa aatgggtgct ggcttgtacc aaaagcttga tacctcccag 879121 ctgcagtatt tgcgcaaact agccggaagt ttaacgaagc ttgctgaagg ctgttcagaa 879181 aaaagcggta attaaaaact tctcacatat tttcaccagc tttccgcaaa atgatagagg 879241 atgaaacgaa aggagaaaac aaaatgaaca gaggacgttt aattctgacc aacattatcg 879301 gtttgattgt tgttcttgca attatagctg gaggtgctta ctactattat caaagcacaa 879361 actacgtaaa aacagatgaa gcaaaagtag cgggcgatat ggctgctatt actgctccag 879421 cagcaggtaa agtatctgac tgggatctgg acgaaggaaa aacagtgaaa aaaggcgaca 879481 cagttgcaaa aatcaaaggt gaacaaactg ttgacgtaaa atccattatg gatggcacaa 879541 ttgtgaaaaa cgaagtgaaa aacggacaaa ccgtacaagc tggtacaaca attgcacaaa 879601 cgattgacat ggacaaccta tacatcacag caaatattaa agaaacagat attgcggata 879661 ttgaagtagg aaatagtgta gacgtagtag ttgacggaga ccctgatact acatttgacg 879721 gtactgtaga agaaattggt tatgcgacta actcaacttt tgatatgctt ccttctacaa 879781 attcaagcgg aaactacaca aaagtaacac aaaaagttcc tgtgaaaatt tcaatcaaaa 879841 acccatctga taaggtgctt cctggaatga atgcatctgt taaaatttct gagtaaaaca 879901 gatcagtcat caaaccatga aaggaggttg tcttagatgg ctacaggcaa agaaaaaaat 879961 gcaaaaaacc ctatgtcatt gctgattgtg ctaatggcgg gtttattttt ggcaattcta 880021 aaccaaacac tgcttaatgt tgcaatgccg cacttaatga ctgaatttgg cgtaagtgca 880081 acgacgattc agtggctgac aacaggttac atgcttgtta acggtgtatt gattccgtta 880141 tctgctttcc tgattacacg atttggccag cggagtctct ttctcgtcgc gatgttttgt 880201 tttacgctcg gtacgttagt ctgcggtatc gcacctaact tctctacaat gctgatcggc 880261 cgtttgattc aggccgtggg cggaggtatc ttgcagccgc tcgttatgac aaccattctg 880321 ttaattttcc cgcctgaaag cagggggaaa ggaatgggga ttttcgggct agcgatgatg 880381 tttgctccag cggtcggccc gactctttcc gggtggatta ttgagcatta tacatggcgc 880441 attatgtttt acggacttgt gccgatcggc gcaattgtta tcattgtggc tttcttcatc 880501 tttaaaaata tggtggagcc gcaaaaaatc aaactcgata ctcttggcgc aatcctctcg 880561 attgtcggat tcgcctcctt attatacgga gtcagtgaag ccggatctga cggctggacc 880621 gacccgattg tattgtctac agttattatc ggagccattg caattgttgc ttttgttgtt 880681 cagcaattgc gtcatgatga tccgatgctt gatttcagag tgtttaaata tgacattttc 880741 tcactctcga gtgtcattaa tatcattatt acagtggcac tttacactgg tatgttcctt 880801 ttaccgattt atctgcaaaa cctggtcggc tttacggcgc ttcaatccgg tctgcttctg 880861 cttccgggtg cgatcgttat gctgattatg tcaccgatct caggtatttt gttcgataaa 880921 ttcggaccga gaccgcttgc gattatcggg cttctcgtga cagtggtaac aacgtatcaa 880981 tacacgcaat tgacaattga tacaccatat acacacatca tgctgatcta ttcaattcgt 881041 gcatttggta tgtctctctt aatgatgcca gtcatgacag ccgggatgaa ccagcttcct 881101 gcccgtctga acagccacgg aacggcgatg agtaacacgc ttcgccaaat cagcggatca 881161 atcggaacaa gtttaattac gacgatttat acaaaccgga cgacattcca ttattcacaa 881221 attgcagata aaacaagcac ggcggacccg aacttcctcc atgcgttcca aaatgcagtt 881281 tcgaatttaa tggtgaatat gaatgtgtct tatgatacgg cgaaaacata tgtgtactca 881341 catatttata aacacgcatc actcgattcc aatgtcatgg ggataaatga tgcctttatg 881401 tgggcaacct tattctgtgt agcaggtttg attttaagta tcttcctgcg tgacgtcaga 881461 aaagataaat tgcgtaagaa gaaaaaagag gagctttcat tacttcctgc tccaaaagaa 881521 gctaaggaat cttaatctgt acagggaggt ttcctgaatg aaaatttatg tagtgtatga 881581 tagtgaaggc gaacatacta aagtgcttgc agaagcgatt gctgaaggcg cgagagaaaa 881641 cgacgcggct gaagtgttca tcgaccatgt agatcaggct gatatccgca agcttaaaga 881701 tatggatgcg attatttggg gatgcccagg gcatttcgga acaatcagct ccggtcttaa 881761 aacttggatc gacagacttg gctacttgtg ggctgaaggc gagctgatca acaaagtcgg 881821 tgctgtcttc tgcacaacgg caacaacaca cggcggcttg gaaatgacaa tgcacaattt 881881 aatcacgccg atgttccacc aaggcatgat tgttgtcgga ctgcctggca acgtgcctga 881941 aaacgcactt tatggctctt attacggagc aggtgtcact tgtccggtag acagtgatga 882001 gttaatgtct gaggaaggta ttcagcttgg acgcgcgttg ggaagacgtg tcagccaagt 882061 cacaggaaac ctaacagcag gacagtaagg agaggttgaa atggccatta ttatagcaat 882121 aattgctgct gtcattgtca ttgcggccct tattacattt aacgtccgca acgcctcacc 882181 tggacctgag aagcaagaag caaccgatag aatcgcacct ccagaagagg aaaaaaacga 882241 agcgcattac cctgctgaag caagggctgc cgagcatacg ccatccgttg tcaaaaacga 882301 ttctccaaaa gagaagcgtg acacaatggg tgatgatatt tacaggcagg cgctgcaaaa 882361 gtttaagcat tctgatgaag ttcatgcaga agaagaggtc actgaggaaa gtgacaaaat 882421 gcaggaccgc agctatcgtg atgcgctgct ctctatgaaa aataagaaaa agtaatgaaa 882481 aaggcaaatc cgtttactca tgcgggtttg ccttttttgc tgtttccatc aattatgttt 882541 ttatcaaata aatccatgga atatgttgta ttccaccttg atctagtgta ctatgttact 882601 catacaccga ggattttttc cgggaggtaa agacatgaat tcttttttag gtttattaaa 882661 gaaagatatc aagctttcaa gaatgtggct gctagtatgg atatgcggaa tcattttctt 882721 attgggaaca ggccatatta tagcttctcg cacgaaagaa cctctagtca tttttggttt 882781 ttttgttgca gttgcttttt ttctgctttt cttatctcct gtttttgttt tttatcacct 882841 tcgcaaggaa gggaaatcac agctttggct gtacaatcca aatggcggct tatggctgtt 882901 ttcttctaaa ttggcagcat ctttgctcta tcaatttgtg attcagttgg cattaacagc 882961 ctatggcata tggatgtatc atatgctctc tgtaaaaaat ctgctggagc atcaagttga 883021 tataacgagt acagtggctt tgctgaatat gtatgggctt atttcttcgt tagatatgtc 883081 agtaacagtc attgtgtttt ggactgtttt tcactctctc agaaattggc gcggaatgcg 883141 gtgggctgcg atggttctgt tggtcgcaat gtggttattc ttcgatgaat acatcataag 883201 ccctttggtt gaatctcaaa agcatttctg gcctgtaaca gtctattgca attttgattt 883261 ccacttccac aatgtttgga gattggaact aaaacctatc catctgtctg tgctagggtt 883321 tcctattgct atagtcatca cattcttgct gctcatcatg gcttcaaaac tgcttgatcg 883381 taaagtagag gtgtaaatat ggacaatcaa ttccaatcct cgaaaccgat ttatctgcag 883441 atcgctgatc agatctttta taggctggtc aggaaggagc tgctcccagg agacaagctt 883501 ccttcagtaa gagaaatggc gattcaaact aaagtaaatc ccaatacaat tcaaagaact 883561 tacagtgaga tggaaaggct gggtattgtg gagacaagaa gaggtcaagg gacgtttatt 883621 gcggaaaaag cagaaatcgt agacgagctg aaagacaagc tgacacgaga ggtgctggaa 883681 ggctttgtca agcaaatgaa agagctgggg ctaacgaaag aagaaatgtt agaagggatt 883741 aaaacattca cagagggagg ctaaaatgga aatcaagcta gaacatgtat caaaaaaata 883801 cggccgccat acggccgtca atgatgtgtc aatcacccta tcatccggac ggatttatgg 883861 cctgattgga ccgaacggca gcggcaagtc aacgaccctg aaaatgatgg ctggccttct 883921 gtttccgact tcaggatttg taaaagttga tgaagagcag gttacgagag aaatggtgcg 883981 tcaaacggct tatcttactg agcttgatat gttttatccg catttcactg ttaaagatat 884041 ggtgaatttt tatcagtcgc agtttcctga ttttcataca gaacaggttt ataagctatt 884101 gaatgagatg cagctgaatc cggaaaaaaa gatcaaaaag ctatcaaaag gaaatcgggg 884161 caggctgaaa atcgttcttg ctttagcgag acgggcagac gtcatcttgc ttgatgaacc 884221 tttttccggg cttgatccga tggtcaggga ttccatcgta aacagccttg tgtcgtacat 884281 tgattttgag cagcagattg tcgtgatcgc gacacatgaa attgatgaaa ttgagacttt 884341 gttagatgaa gtaatcatcc tcgccaatgg agaaaaagtt gcgcagcgtg aagtagaaga 884401 tattcgtgaa caggaaggca tgtctgtttt gcaatggttt aaatcaaaaa tggaagtttg 884461 ctagaaagag gaggaatatg atgaaaacag tgttggaatt gaaaaacgtg actaaaaaca 884521 tcagaggccg aacgatcatt gatgatctca gttttacgat tcgtgaaggc gaggtattcg 884581 gttttttagg accaaacgga gcggggaaaa cgacaaccat ccggatgatg gtggggttaa 884641 tgaagctgtc gaaaggtgat gtcctcattt gcggccaatc aattacgaaa gaatatgcca 884701 aggcgattaa gcatatcgga gcgatcgttg agaatcccga gctgtataaa tttttgagcg 884761 gatataaaaa tctccagcaa ttcgcaagga tggtcaaggg tgtcacgaag gaaaaaattg 884821 atgaagttgt tgaactggtc ggtttaacag acagaatcca cgacaaggtg aaaacatatt 884881 ctctggggat gagacagcgt cttggcttgg cacaatgcct tctgcacgat ccgaaagtgc 884941 tgattttgga tgaaccgaca aacggccttg atccggcggg gatcagagaa atcagagatc 885001 atttaaagaa gctgacccga gaaagaggaa tggctgtcat cgtttcaagc cacctgctgt 885061 cagaaatgga actgatgtgt gatcgaattg cgattctgca aaaaggaaag ctgatcgata 885121 ttcaaaatgt aaaagatgaa aacattgatg agaatgatac atatttcttc caggttgagc 885181 agccgagtga agccgctact gttttaaatc agtacgattt gctgagtaag acaaatggtg 885241 tagaaatcaa actggctaaa gaggaagtcc ctgcggttat tgaattgctg gtgatgcagc 885301 aaatccgtat ttatgaggtc aaggtcataa caaaatcatt agaggaccgt ttcttagaaa 885361 tgacaggtga aacaaaagag gaggttcagc atgcttaatt tgatttataa tgagtggctc 885421 aaaattttca gccgtgccgg aacatgggtg atgatcggaa ttctggggct gacaatggtt 885481 ggatttgcat ttttggcgaa tcatttttct gccggtgaat caaattccca ttggaaacaa 885541 gagcttcaag cacaaaacgc cgaattaaag aaagaaatca aagaagatcc ttcactgaaa 885601 gatgggtata aagaaacaat cacactcaat gactatcgca tcgagcataa tatccctagt 885661 gacacgggct atacggtatg gtcttatgta acggattcag caaactttac catccttacc 885721 ggtctgttta ctattatcat cgcggccgga attgtcgcga acgaatttaa ttggggaacg 885781 attaagctat taatgattcg gccgctcagt cgttttcaaa ttttgatgtc caaatatatt 885841 acagttctcc tgtttgggct cctgttgctg ttgattttat ttatcggttc tactttatta 885901 gggttgatct tcttcggaac gggtggtgaa accgccgcga atattcattt aatctataag 885961 gatggccatg tcattgagca aaacatgatg gggcatttgg ctacaacgta tctttctgaa 886021 tccgtctcgg ctttaatggt ggcgacgatg gcgtttatgc tgtctgcggt attcagaaac 886081 agctctcttg cggttggttt ttccatcttc ttgttggttg ccggtacgac tgcaactgca 886141 tttattgcag cgaaatttga ctgggcaaag tatatattgt ttgctaatgt cgacttgact 886201 cagtatgtgg atggcacacc gttaataaaa gggatgacta tgacgttttc tctcgtcatg 886261 ctggcgatct actttatcat cttcctgttg cttgctttcg gaatcttcat gaagcgggat 886321 attgcaaact aataaaaaaa gctgttttgc ttatgcaaaa cagctttttt gtcaaaataa 886381 aaactgcagg tttgcacctg cagtttttca tatcaattta tgcttacgct tctttagtaa 886441 cgttagcagc ttgtggtccg cggtttcctt caacgatttc aaaagaaaca gcttggcctt 886501 cttctaaagt tttgaagcct tcgccttgaa tagcagagaa atgaacgaat acatcgtctt 886561 gaccttctac ttcgatgaat ccgaaacctt tttcagagtt gaaccatttt actttacctt 886621 ctaacatgaa atttcctcct aaagcgatca taacgcttaa attcactatt cttgctctta 886681 acaaactttc aagacgaaaa ctcttacaaa actttcttct taaagatagt tcgaacaaaa 886741 ataattacct ttactctacc agtaatcttc agaaaaaaca actgcttatt gaaatttttt 886801 tcggaaaata ccatatttat ttttcaattt gatatttatt tacggaaatt catctgtttt 886861 ctcgatatgt gatcatacgt ttgccttagt attccttcat tttgggaaga taagtaatag 886921 gaattgacaa ccttattgga tatgagtaag gtaaaagtta atcaatatta caaatgacaa 886981 cgtttatcaa ctaagagagc gtatgatttt tatgtctgat attgcttgca tgctctaata 887041 catagatagg agtatggtca caatgaaaaa gtggcttata tgcagtttcg tccttgttct 887101 tctcgtttca tttactgcat gttcaccgtc tgcagaacat gaatcgataa aaatcgggat 887161 tgctgagtct gacggggcaa tatggaacta tattgctcaa aaggctgaag aggcagggct 887221 ggatattcag ctgatccctt tttctgatta tgcggagtct gatatcgcac ttgctaacaa 887281 agaaattgat gccaacgcct ttcaaaccat ttcatatttt cagtcgttca ctgaaaaata 887341 caaacttaat ttggcaccgc tcgggacgac atacataacg cccatgggca tttattcaaa 887401 acgatatgaa cgaatccgag atatatcgcg gggagctgtc gtttctgttc cggataaagc 887461 gttcgatttt ggcagggcgc ttacggtgct ccaggaagcg ggtttgctaa cgctgaaaaa 887521 cggatttaac ggaacaggtt cagttgatat gattaaagat aatccgagac acctgaaatt 887581 aaaagctgtc cggcaacagg atgcagtgag cggtgccgac gtgtttgtca tgaaaccatc 887641 agaagcaaaa aaagcgggct tgaacccgaa aaagcatacg ctaaagagcg gcggactcat 887701 gtctgaggaa gagatgaatt tgattgttgt cagagcggag gatcaagatc gggaagcgct 887761 gcaaaccatt cttgagcttt atcaagctga tgatacagcg gcatttatag aaaaagaata 887821 tcagggagat cttgtcccgg cttttctgcc tttgaaacgt ctttcagatt ggaagaatga 887881 attcgaacat tgaattcatt cttttttttc tgaaaaacac actctgttcc gtcccgtttc 887941 tttcgctttg taaagcattt gatcggcaag aatgggcaag gatcctggct gttccgtatt 888001 attggggtaa tgagcggccc ctagtgatat cgtaactgaa agctcgtcgc cgtttgttaa 888061 tacaatcggt gcatcactta cagtgctcct gatccgttca gcgatccggg ctgctttatc 888121 aagagaacag ttcggcagga gcacggcaaa ttcttcaccg ccgatccgag cggcaggatc 888181 agtatttcgg atggtctgct tcagacgtaa ccctagctct ttgagcacct gatctccttc 888241 atgatggcca tattggtcat tgatggtctt aaaatgatcg atatccatat aaatcagtgc 888301 aaattgaaaa tgcggggtat cggccgcctg ctgatacaga gcttttgtgg tttcttcaaa 888361 ttttcttcgg ttatacacgc ctgttaaaaa gtcaaagtgc gcctgaaact tatattgttt 888421 aaaaagaaga tgtgcatttg tttcatgatc aataatatat aaactgagca tgccgcccgc 888481 tattgatatg atccaaaaat acaaatgaag ttcgtatgaa tgtaaatcta taagaaaata 888541 aaaggaaaag gagatcaagc tatttgtgat tattaaaaga tagaaagcat gttttagttg 888601 aacttttttt cttctagaaa caatgagtga cggaatggca gcgatacaaa tgataataac 888661 cgagtatagt gcagatgtgt tcatcgtaat cagcaagcgg cctgcagtga tcatggccag 888721 ggccgttgcc gttgaaaccc agcctccata aagagcggca atcataatag ggatatttcg 888781 aagatcaata attgaatgct gataggtaaa tccaaaaacc atcagaataa ccccgagcaa 888841 accgcaggcc agtcctttaa cagcttgaaa ggatatgctg tcttttttat gtactagcct 888901 ttctttaaac aggtgggtga agagataatt aaatgtgatt aaaatggtca aatttacaaa 888961 cagttctttc agcaaatatt atcaccctta tataaggtac taaagatgga agggaaagaa 889021 aagaacaaaa aaggcattat ataaggtttt tttacttgaa ttgataagtt aaaataattc 889081 gcacttgacc catcggaatt agtgtaatat agtaaatgag aaaatttgaa gggagagttt 889141 acctgctttg gagactttac tggttgtatt acatgtattt attttatttt tacttatctt 889201 agggctcttt gttatgcaga aaaaacatgt ttccttctct aaacgtgtat ttactgcgct 889261 ggggctgggg attgtattcg gatttgcgct tcagctgatt tacggcccga cttcaaatat 889321 agtcattcaa acagccgact ggtttaatat tgccgggggc ggatatgtca aattgcttca 889381 gatggttgtc atgccgctcg tctttatttc gattctcggc gcctttacaa agctgaagct 889441 gacaaaaaat cttgggaaaa tcagcggttt gattatcggg attttagtag caacaacagc 889501 agttgctgca gctgtcggta tcgcgtccgc gctttcattt gatctgcagg cgattcaggt 889561 tgaccaagga agtacagagc tttcacgggg acaggagctt cagcagaaat cagaggatat 889621 gacagcgaaa acgctgccgc agcagattgt tgaactgctg cctggaaacc cgtttttaga 889681 ttttacggga gctagaccga cttcaacgat cgctgtcgtt atttttgccg ctttccttgg 889741 agtggcattc ctcggcgtaa aacacaaaca gccggaacag gcagaaacat ttaaaaaact 889801 ggttgatgcc gtttatgcca ttgtcatgcg tgttgtcaca ctcattttga gactgacgcc 889861 ttatggggtg ctggccatca tgacaaaaac aattgcaacg agtgatcttg acagcattct 889921 aaaactgggc atgttcgtga ttgcatcata tgccgcgtta atcactatgt ttatcattca 889981 tttgctgctg ctgacgttca gcggcttgaa tccggtgatt tatttgaaaa aagcggtgcc 890041 tgtacttgta tttgcattta cgtcaaggtc tagcgcaggt gctttaccgc tgaatattaa 890101 aacacagaga agcatgggtg taccggaggg aatcgcaaac tttgccggtt cgttcggtct 890161 ttcgatcggc caaaatggat gtgccggcat ttatcctgcg atgctggcga tgatgattgc 890221 tccgactgtc ggccaaaatc catttgaccc ggtgtttatt atcactgtta tcgcagtcgt 890281 tgccatcagc tccttcgggg ttgccggagt cggcggcgga gcgacattcg cggcgcttct 890341 tgttttatca tcattaaaca tgcctgtcgc gctcgccggt ttgttaatct caattgaacc 890401 gttaatcgac atggggcgta ctgctttgaa tgtcagcgga agcatgacat ccggtcttat 890461 tacaagtaag gtcacaaaag aaattgatca aggggcattt catgatcaat ccagagtgat 890521 tgaagctgaa gaagcgtaac atatgaaaac gtgtaatcca agaggattac acgttttttt 890581 aacggccagg ctctaagtcc tccagcattt ccatcatcgt gttgtcgtcc atgacattca 890641 ttgcgttttg ttcaaaatga atgggttcag cataatgcgg ctgtcttttt ttcgcggctg 890701 tctcagtttg cctagtttga gactgtgtat gctgatgctg tggttgctgc tgtccagcgt 890761 gctggtgctg acggccattt tgccgctggc tttgatgctg cgaacggtcc tggttatcac 890821 cgctgcttcc gctgcttccg ctaaatgctt gtttgaccat gtttcctaca ttagaagcat 890881 caaacgtgtt attttctgaa tttcgtctgt tcatttgtcc tgtgataaac ccgctgattc 890941 tttggcggat ctgaggtgat aatgcagtaa taagcatagt tgatcctatg atcaatgctg 891001 cggggctgat tcctcttcgc tggttgaaca acatgatccc tcctttgcag tgtattcata 891061 ttttccccct cgttagacaa attaaccgtt atatttcccg ggaaagcatt tcctccagat 891121 ttgcatgcat aattaaagcc agttagaaaa acctataagt aaagtgataa aggaggaatt 891181 cacatgtttg gaaaaaaaca agtccttgcg tctgtgcttc ttatcccttt gcttatgact 891241 ggctgcggtg tagccgacca aggtgagggc agacgtgata ataatgatgt aagaaacgta 891301 aattatcgaa atccggccaa tgacgatatg cggaatgtaa acaatcggga taacgttgac 891361 aacaatgtta atgataatgt caataacaat cgtgtaaatg acgataataa caacgaccga 891421 aaacttgagg ttgctgatga agcagctgat aaagtaacag acctaaaaga agtaaagcat 891481 gccgatatca ttgtggctgg aaatcaagcc tacgttgcag tcgttttaac caatggaaat 891541 aaaggtgcag tagaaaacaa tctgaagaaa aaaatagcca aaaaggtaag atctactgac 891601 aaaaacattg ataatgttta cgtttcagct aaccctgatt ttgtagagcg tatgcaagga 891661 tatggaaagc gtattcaaaa tggtgaccca atcgccggat tatttgatga atttacacaa 891721 actgtacagc gtgtattccc taacgctgaa taaatgaaag aagccgcaca atttgtgcgg 891781 ctttttcttt gcgttaatga cacactgcga actcaggctg catagagtaa aaataaaaag 891841 gtacaagacg gaccggctca gggagggaga cgtttgcggg atggcatagg aaagcgtgcg 891901 gcatccgctc tattcctgtg cggagtcctt gtgatgctgg ctgtaagctc agccatcgta 891961 tcaagcgcga tgtatatcct gtcttttcca ggtcaggcat ctggaataac aaaagaacaa 892021 gtgacgaagc acatgaagaa agagtcattc aaacaggccg atatttatta cacttctaag 892081 gaaaagtcct tactgccatt gacgaaagaa acgcttgaat atgcggtcag tattaatcag 892141 attatgattg gatattcgaa tcaaaagcct attgacatta ttttttttcc taatgaaaaa 892201 cagatggagg cttactccgg tttattggat gtagttggtt tttattctga acgggagcag 892261 ctgatcggat tgttgcctga agagaaaaag aaactgttag aaggggacga ggtagcggtt 892321 tatttgtacc agagattgtt gattcatgaa tactcgcacc atgcgtttca ccagaaattg 892381 aaggagcttg agacggatcc cgatgagttt ccgttatggt ttcatgaagg gttaagcgag 892441 tggattgcga actatgaatt gctcatagat ccgatcacgt tttctgtcgt gccctttgac 892501 cgtttgcaga ctgatcgaga ctggcaggaa gctagagccg aatatgacac tgatgtctat 892561 ttgcaaagct tttatatgat cgatgagctg acggacaaat acgggaaaga cattatttca 892621 gaaatgatta aggaaacggc aaaaaaaggg gactttgaaa aagggtttaa atcagcaaca 892681 aaggaaagtc ttgatcaatt tgaaaaagat tttaagaaaa aatttgaaaa aaacagtgcg 892741 gcattggata gtatctatcc aatgcctttg ttattagtga agtccttgct gacccattcc 892801 gccttgtgtc ggaggcattt gtccttgggc aggggcgaat gaatttcgca gctgttccat 892861 atcctgcgca tcaagctgag gaacctggta atagccgtgt ttgttttggt ataggaaaat 892921 ttcaaatgcc atttcaacat actcctgaat ttgcgcagac agtacgcgtc ttacggccgg 892981 atttgtcatt tccagagaag ccatcgtcag catagaagct tgtgctttaa tcgcgcaaag 893041 catttgtcgg ctgatgatgc tgtcatcaat atcattcatg gattgaacag gttttttagg 893101 ctgtgacggc tgcatgccgt aaacagtctg gttgtcttcc ttcatcatat aagttgctgt 893161 tttttgtgaa ggttcgcttc ctgttttgaa gcattctgca gttatattgt attgagatgt 893221 gatgaattga tgttgacgat caaggatgtt tagtaattct tgatccttac agaattgtct 893281 cagcatcata aactgatcaa gcacagtaag tgttccggaa agcacctcat gcatatcaaa 893341 catttcatgt ccgccgtggt ttttatgcgg tttgccagga atacctttgt tcatttggga 893401 ttgctgctgc tgattgaact gatccaaacc gaattcctcc ttttttttca gatcagctgt 893461 attttgtgtc agtctgccgt gtattatgca gaagcctgaa aggaattata tgctgtctgt 893521 cgaaatgata agcagacaaa atcgttgtca ttatgtgtat aagggaggaa atatgatgag 893581 gcgtattctg catattgtgt tgatcacggc attaatgttc ttaaatgtaa tgtacacgtt 893641 cgaagctgta aaggcagctg aaccgcaaca gcctatatcg attgagaagg caatacagca 893701 aaaagaagga caggcacttg tcgaaggata tgcagtcggc caggctgttt ccccgcagca 893761 ttataaactg acaagccctt tttcaaatga ttataatgtt gcgctggcag accgtaaaaa 893821 caaaacatcg cccgaacaca tccttcctgt gcaaatcccc tccgccttca gaagccaatt 893881 tgggctgcaa accaatccgc ttcttcttgg gaaaaagata acggttcaag gaaagcttga 893941 aaattacttt aacacgacag gacttaaaaa cgttcagtcg atgaacgtaa ccgatgacac 894001 aaaaactccg ccggctgaac agcaagtgac cataaatgaa gcacggggaa ggctgaatga 894061 agaagtaacg ataaaaggga tcattacagc tgatcaaaac gcaatcggag gcgggaagct 894121 gtcgaccttt ttgcaagatg aaaccggagg cattaacatt tattcgccat cccctgaaca 894181 atttcccgaa ttaaaagagg gtatggatgt cacggtgaca gggaaaatca cgtcttacca 894241 ggggctgaaa gaaatcgttc caaactcatc aggcatcaaa atcaaccagt caaatcaatc 894301 cctccccgcc cccaaacact taacaatcaa tgaacttatt aacggcagcc taggtgatca 894361 gtatgaagga cgccttgtga aactaaccgc ttttgtttcc tcaattccaa gttctcctgc 894421 cggcggcggt tacaatgtaa caatgattga tgacgaccat catgcaatga cgctccgggt 894481 tatgaatgaa acaggggtga taaacgagct tgatgagggc aaatggtatg aatttaccgg 894541 tgtgttaagc agataccaaa cctttcagct gcttccgcga aaatcggctg acctgaagct 894601 gcttgaagag cagcccgcac ctccgtctgc agagggagaa tatgaaggga ttgttgaccg 894661 ggtagttgac ggcgatacca ttcatcttaa atctccggtg cttggaacga caaaaatccg 894721 gtttgtaaat gtagatgcac ccgaaacata tcacacacca aaaaatgacg cagatgaaaa 894781 tcaattaaga tttggcaaaa aagcatctga ctatctaaaa acggttctgt ccccgggtga 894841 taaaattact gtcaaggtcg ggagtgaagc caaggacagc tatggcagat tgctcggaca 894901 agtcataacc gaatcaggtt caaacgtgaa cttagagctt gtaaaaaacg gctatgctcc 894961 gacgtatttt atttggccgg ttgacaatga agaggattat cagcaatttc aggccgcagt 895021 agccgctgca aaaaaagatc aaaaaggaat ttggaatgaa aacgatcccc tcatggaaat 895081 gccgtttgaa ttcagagcca gagagcaagg gaaaggcctg acaagatatg tgggggactc 895141 gtcgaataaa acatatgtgc agccagctga ctggaagaag atagctgtgg aaaacagaat 895201 tttcttcgcc tcagcaagtg aagcggagag cgcgggatat aaaaaaaggc aaacggcacc 895261 tcaagaacat gtgccgctta gaattctcag catgaatgat ttgcatggca aaatcgatca 895321 gcaatatgag cttgatcttg atggaaatgg aactgtagac ggcacgtttg gacgcatgga 895381 ttatgccgcc gcatatttaa aagaaaaaaa ggctgaaaag aaaaactcgc tgattgtgca 895441 cgcgggagat atgatcggcg gaagctctcc agtttcctct cttcttcagg atgaaccgac 895501 tgtagaactg atggaggaca tcggatttga tgtcggaacc gtgggaaacc acgaatttga 895561 tgaaggcacg gatgaacttc tgaggatctt aaatggcggt gatcatccga aaggcacaag 895621 cggatatgat ggacagaact ttccccttgt atgtgccaat tgtaaaatga aatcaactgg 895681 agagcccttt ttgccggctt acgacatcat taatgtggag ggcgtacccg ttgcttttat 895741 cggagttgtc acacagtcgg cagctggcat ggttatgcct gaaggaataa aaaatatcga 895801 gtttacagat gaagcaacag cggtgaataa ggcggccgaa gagctcaaga aaaaaggcgt 895861 gaaggccatc gcggttctcg cacatatgtc agctgaacaa aacggcaacg ccattaccgg 895921 tgagtctgct gatcttgcaa acaaaacaga ttctgaaatt gacgtgattt ttgccgcgca 895981 taatcatcag gttgttaacg gtgaagtgaa tggaaaactg attgttcaag cgtttgaata 896041 tggaaaagcg ataggtgtcg ttgatgtaga gatcgataaa acgacaaaag acattgtcaa 896101 aaagtccgcg gaaatcgtat atgttgatca aagtaaaatc gaaccggatg tcagcgcgtc 896161 agccatttta aagaaatacg aaacaattgc ggaaccgatt atcagcgagg tagtcggcga 896221 agccgctgtt gatatggaag gggggtattc aaatgacggc gatacacctc ttggaaacct 896281 gattgcggat ggtatgagag ctgccatgaa aacggatttt gcccttatga atggcggcgg 896341 catacgtgaa gcgctgaaga agggtccaat tacgtgggga gatctttaca atattcagcc 896401 gtttggaaat gtgttaacga agcttgagat taaaggaaaa gatttaagag agattatcaa 896461 tgcgcaaatc tcgccggttt ttgggcctga ctacagcatc agcgggttta cgtatacgtg 896521 ggataaagaa accggaaaag cagttgatat gaaaatggca gatggcaccg agatccagcc 896581 cgatgccaca tatacattga ccgtcaacaa ctttatggcg acggcgacag gagccaaata 896641 tcagccaatc ggactgctgg gaaaaaatcc ggtgacaggg cctgaggatt tggaagcgac 896701 agttgagtac gtgaagagtt ttgatgagcc aattgcgtat acaaaagagg gaagaattaa 896761 gcttgctgaa gccagtgata ttgaagaccc tgtaacagaa gacccgataa cggaagagcc 896821 tggagatgat ccggggacgg aggatccgat taaagaggat ccaaggccag gtgaagattt 896881 gcctgatata aaagaaactc cgggaacagc accggttcat cagcttccgc cttcagccat 896941 ttcgagattc aatgaaatac caatcaacaa cacaaaaacc gctgatactg ctaatagcat 897001 cagcacattg ccgttacaaa ccgagactgc ggaaagcggg tctgatcatc agcttccgga 897061 tacgtcagcg ggctactata actttatggt aatcggtgcg gcggtgacat tgtcaggaac 897121 ttatctatat gtcagaagaa aaaggagcgc ctccagaacg tgaaaaaagt tattccacta 897181 ttcatcattg ctgccggcct agtgatcgca ggctatggag gctttaaatt gatcgatacg 897241 aatacgaaaa cggaacagac attaaaagaa gcaaagctgg cggctaaaaa gccgcaggaa 897301 gcttcgggga cgaaaaatag cacagatcaa gcaaagaaca aagcatcatt taagcctgag 897361 accggccaag cgagcggcat tttagaaata ccgaaaatca atgcagagct tccgatcgtg 897421 gagggcaccg atgctgatga tttagaaaaa ggtgtcgggc attacaagga cagctattat 897481 cctgatgaaa acggacaaat tgtgctgtca gggcatcggg ataccgtgtt tcgccggacg 897541 ggagagctgg aaaaggggga tcagctccgt cttctcctgt catatggaga attcacatat 897601 gaaattgtaa aaacaaaaat tgtcgataag gatgacacat ctattatcac gctccagcat 897661 gaaaaggaag agctgattct gacgacctgc tatccgtttt catacgtcgg aaatgccccg 897721 aagcgctata ttatatatgg aaaacgagtg acttaaaaag ccgaggcagt gcctgcggct 897781 tttcttcatg aaaaatatgt gcggcaaagg tttttcatat cagcagggaa aggggcttca 897841 gcaactatga gctcgtctgt tatcgggtga accgcttgta ctttattggc gtgcagtgcc 897901 tgcctgttta gcagcttgct cccgcctccg taaagcgagt ctcctgtcaa cggatggccg 897961 aggctcgcca gatgaacacg gatttggtgt gttctgcctg tttccagctc taattcaacg 898021 agcgacagcc gttctttcgc attgctggcc attaccttga aatgagtgac ggctgtttgc 898081 ccgcctggtg aaacccggcg tcttgtcggg tgtgagcggt ctctgccgat cggtgaatta 898141 attgtccctt ttttcgtccg tagcttacct tcagcgatag cggtatacgt acgcttcagc 898201 gtctttttct ctaactgctg gtctaagatg gcgtgtgcca aacgatgctt ggcaaaaacg 898261 atagcgccag atgtatcctg atcaagacga tggacgtggc gcaccttaca tgtttcgcca 898321 tttatctgat aatgatacgc gatcaaatta gccagtgtgc cggtttgccc atcctcattc 898381 ggatgcgtcg cgatgccagc gggtttattg atgatgagca tatgattgtc ctcaaataaa 898441 atatcaagct cgccatactc cggaatgacc gaagatgctt cactttcctg aagatcaatg 898501 aacacgcggt ctcccttttt tacaatcata ttgtttaaga cggattcgtg attgaccttt 898561 atctgttgat gggacatcca gtcttgtatc actggtttag aagctttgag cgctgttttg 898621 agtacggaaa acagccattg gccgtcctgt ttttcattga tgaggatctc aagccctctg 898681 cctttttggt tcatgttaaa tggctccttt tcgaagcgga aggctgctgt ttctcatagg 898741 aaacacttac cttagctttc gcgttttttt ctgtgctatt cttgagtaag acttaggata 898801 ttcgatggca agaaaggtga ttgacgtgag aattgtgaac gcagcaactg cagaacagga 898861 gagctttatc aaggagctgt ctatggagct gatccatgat gtatttcctc tttatttctc 898921 cgaactggac attcagcgct ttaaaaagaa aggcgttctg tctttaaata accattatta 898981 ccaaggaaca ttaaaagaag catttcaaat tatggcttgt ctgcaaatga tacatattat 899041 cctgaccaag ccttcgccgc actctgattt gagtgatcag gcgatttttg aaaaaaacag 899101 caagatgctg aatgattttg ggatttattt tccgtttgct ttttctgact ttcaaaagaa 899161 gactaacaaa gcctttttcg gtcaaagaag gctgatataa tcatgcggca agggcttttc 899221 tatttttaga aaagctcttt ttgtatcaga gaaatcatat cataaaacct ttcctctaac 899281 tcccttttta aacggctcgt gtctgaacat actaatgatt gaaaggggtg ctgacaatga 899341 gttcagttaa agatacaatg acaacgcagg tggcaaccgt ttctccgaat caaacgattc 899401 aggaagcggc ttctctaatg aaacagcata acgtcggggc gatccccgtt gtagagcaag 899461 gtgttttaaa aggaatgctg actgaccgtg acattgcatt aagaactaca gctcagggcc 899521 gtgatggcca gacacccgtt tcagaagtga tgtcaacaga actcgtatca ggaaacccta 899581 atatgagtct ggaagacgcg tcgcagctga tggcccagca ccaaatccgc cgccttccta 899641 ttgtagatca aaacaatcta gtcgggatcg ttgcgcttgg agacctggca gtcaatcaga 899701 tgtcgaacga gtctgcggga tcagcgctga caaacatttc tcaccaaaac attcattaat 899761 aagaaagagc ttgcagtgtg caggctcttt cttcacataa aaccttactt tttgaaagca 899821 gacttgtttc ggggtatagt gagtgtatac atatgtctca attcgtacta aaggagttgt 899881 acccagtgat taaagcgtta atttttgatt ttgacgggct tattctagat acagaaacac 899941 acgaatatga ggttcttcag gaaatatttg aagagcacgg ctcagtgctg ccgctatctg 900001 tctggggaaa ggtcatcgga actgctgcgg gtttccggcc ttttgaatat ttagaagagc 900061 agatcgggaa aaagctgaac catgaagagc tcacacaatt gagaagagag cggtttgcca 900121 aacgcatgga atcagaaaaa gcgagacctg gtgtcgaagc gtatttgaat gcggcaaagg 900181 atttaggctt aaaaataggc cttgcctcca gctctgatta taaatgggtg tccggccatt 900241 tgaagcaaat cggcctgttt gatgattttg aagttattca aacggcggat gatgtggaag 900301 aggtgaagcc gaatcctgaa ctctatttat tggcggcaaa gaacctgggg gtatcgccag 900361 cggaatgtct cgcgtttgag gattctgtca atggttcgat tgctgcgaaa cgtgcaggca 900421 tgaagtgtgt cattgtcccg aataaagtaa cgggtacctt gatgtttgaa gactatgatc 900481 acaggcttga atcaatggcg gagatggagc tcgccctatt gcttgatcat ctgaactcac 900541 aaaactagaa aggagcgagt aggttgtctg agaaattaga tttgacccgg tttgaaaaga 900601 aaatggttat ccgcaatatc gaagagaaag acatcgacaa gattatcgat cttcaaaagg 900661 actgctttcc aggaatggag ccttggaagc gggagcattt aatcagccat ttggagcatt 900721 ttccggaagg acagttttgt gcagaattcg aaggtgaaat tatcggttcg tgctcaagtc 900781 tcctgattaa ctttgatgaa tatgatgacc gccatacgtg gcaggacatt acagatgacg 900841 gttatatcac caaccataat cctgacggct tgaatatgta cggaattgaa gtcatggtgc 900901 acccgaaata cagacgaatg aagatcggcc accgtttgta cgaggcgaga aaggacttag 900961 ccagacgctt aaacctgaaa agcatcatca taggcggacg gattccaaac tatcacaaat 901021 atgcagagga aatgacagcg agagagtatg ttgaacaggt gacacgccac caaatttacg 901081 atccggttct ttcttttcag ctgatgaacg gctttaccct tatgcgaatt aacccgaact 901141 atctcccgga tgatacagct tcgatcaagt atgcgacgct gatggaatgg aataatgtcg 901201 attatctacc gcagcagaca aaacgctatt ataaatcggc gttccctgtt agaatttgtg 901261 tgatccaata cgaaatgaag aaaatttatt cctttgagga atttgcgaat caagtagaat 901321 actatgtcga tgttgcttcc gacgcaagat ctgattttgc ggtgttcccg gaaattttca 901381 caacccagct gatgtccttc cttgaggaac ggtcaccgag cttggcggtg cagagaatta 901441 ccgagtatac agaagattac atcagcctgt ttactgactt ggctgtgaag tataacgtca 901501 acattatcgg cggatctcat ttcgtcgaag aggaaggcaa gatctataat atcgcttacc 901561 tgttcagacg ggacggaacg atcgagaagc aatacaaact ccatattacg ccgaatgaac 901621 gcaaatggtg ggggatcagc gcaggagacc aagttcgcgt gtttgatacg gactgcggga 901681 aaatcgcgat ccagatctgt tatgacattg aatttcctga gcttgcccgg attgcggctg 901741 ataaaggagc caaaatcatc tttacgccat tttgtacaga agaccgtcaa ggctatctgc 901801 gtgtcagata ctgttcgcag gctagagcgg ttgaaaatca aatttatacg gttatctctg 901861 gaacggtcgg aaaccttccg caaacggaaa acatggatat ccaatacgcc cagtcaggca 901921 tctttgcccc gtctgatttt gaattcgccc gagacggcat tgtcggcgaa acaaacccga 901981 atattgaaat ggtcgtcatc ggcgatgttg acctggaaat tctcagaaga cagcgccaaa 902041 acggtacagt gcgccagcta aaagacagac gacgtgatat ttatcatatt caatataaaa 902101 aataattccc aaaaaacccg cctgaattgg cgggtttttt taaacaaaag cggaattgtt 902161 taggtgcttt ctttaaaata aaagtaaatt gtatagtgga tgtgccttat ggagtttctg 902221 tattttcgcc atttcctata tcatacagaa aacggctagg cttcacattg ctattgcaat 902281 ggctgtccaa gttgtttcga gtgcgacctt tatcagtacg atgctgagca ttgtcacttt 902341 gcctgttttg ctttggaagc tgcatcctct ttcttcttga gaaaggggat gttttattat 902401 ttacgcggtt tattgactct gacccggtct ggctttatat tgaaggcagg gaaatcatca 902461 ccaagacatc acataaagag aaggtctgtt tcaattgaat tggcattata gggaacgcta 902521 atgaaatgga gatgatgggg atggaaaaca ttcagcaaaa tcagggatta aagcaaaaag 902581 atgagcaatt tgtgtggcat gccatgaagg gagcgcatca agcggacagc ctgatagccc 902641 agaaggccga aggggcctgg gtaaccgaca cagacggacg ccgctatttg gatgcgatgt 902701 ccggtttgtg gtgcgtcaac attggttacg gcagaaagga gcttgcggag gctgcctatg 902761 agcaactaaa ggagctgcct tactacccgt taacgcaaag tcacgcaccc gcaattcaac 902821 tggcggaaaa gctgaatgaa tggcttggcg gcgattatgt tatttttttt tccaacagcg 902881 gatcggaagc aaacgaaact gcttttaaaa ttgcccgcca gtaccatctg caaaacggcg 902941 accacagccg ttataaattc atctcaagat atcgggcata ccacggcaat acattgggag 903001 cgctctcagc taccggacag gcgcagcgga aatataaata cgagcctttg agccaagggt 903061 tcctgcatgc agctccgcca gatatatacc ggaatcctga tgatgcagac acgcttgaaa 903121 gcgcaaatga aatcgaccgc atcatgacat gggaattaag cgaaacgatt gccggggtca 903181 ttatggagcc catcattaca ggcggaggca tcctaatgcc gccggacgga tatatgaaga 903241 aggtggagga catttgccgg cgccacggag cccttttgat ttgcgatgaa gtgatctgcg 903301 ggtttggacg gacaggtgag ccgttcgggt ttatgcacta cggtgtgaag cctgatatca 903361 ttacgatggc aaagggaatc acaagcgcgt atctgccatt gtcagcgact gctgtgaaac 903421 gggacatttt cgaagcgtat cagggggaag ctccttatga ccgtttccgc cacgtgaaca 903481 cgttcggcgg aagcccggct gcctgtgctt tggcgttgaa aaacctgcaa attatggagg 903541 acgaacagct gattcagcga tcccgtgatc ttggagcaaa gcttttaggt gagcttcaag 903601 ctctgagaga acacccggca gtcggggatg ttagaggaaa agggctgctg atcggaatcg 903661 aactcgtcaa agacaaattg actaaagagc cggctgatgc cgccaaagta aaccaagtgg 903721 ttgcggcgtg caaagaaaaa gggctgatca tcggcaaaaa cggcgataca gtcgccggct 903781 acaacaatgt catccagctt gcgccgccat tttgcctgac agaagaggac ctttccttta 903841 tcgtgaaaac ggtgaaagaa agctttcaaa cgatataata taaaagtgaa ttattaaagg 903901 agcacatgat gagttttcac aaccagccga tcttaccggc tattcgcaat atgaagcaat 903961 ttgatgagtt tttgaacagt tcattctctt acggtgttat tcttgatatt catctcggcc 904021 agctgaaggg cgtgatcaaa gaagcgcaaa agcacggaaa gaacatgatg gtgcacgtcg 904081 atctcattca agggattaag catgacgaat acggtgcgga atttatatgt caggatatca 904141 agcccgctgg gattatttcc acaagatcga atgtgattgc caaagcgaag cagaagaaaa 904201 tttatgccat tcagcgcctg tttttgcttg atacaagcgc gatggagaaa agcatggagt 904261 ttatcggcaa gcataagcct gacttcatcg aagtgcttcc cggcatcgtt ccgtcactca 904321 ttcaggaaat aaaagagaaa acagggattc ccatctttgc cgggggtttc atccgtacgg 904381 aagaggatgt agagcaggca ttgaaagcgg gggctgtagc tgtcacaaca tctaatacca 904441 aattgtggaa aaaatatgaa aactttttga cggaaagtga ttgacaccgc tttcatgcac 904501 tgatacaatt gcactaggtt aatacattgt gatggagaac tcggagacca cagcagctct 904561 ttacggcaaa tgtttatgca cccgtaaagc ggtttgttgt ggttttttta ttctcttctt 904621 ctctatcatg ctttttaatc gtgactttag gaggaatgtg ctatgacagc attttgggga 904681 gaagtcatcg gtacgatgct gcttatcatt tttggtgcag gtgtttgtgc aggtgtcaat 904741 ttaaagaaat cgctttcatt ccagtctggc tggattgttg ttgtatttgg atggggattg 904801 ggtgttgcca tggcggcata cgcggttggc ggcatcagcg gtgcccattt gaatccggcg 904861 ctaacgatag cgcttgcatt tgtaggagat tttccttgga aagaggttcc ggtttatatt 904921 gcggcgcaaa tgatcggagc gatcatcggt gcggtgatta tttatctgca ttacctcccg 904981 cactggaagt caacggatga tcccgctgcc aagctgggtg ttttctcaac agggcccagc 905041 attccgcata catttgcaaa cgttttaagc gaagtgattg ggacatttgt ccttgtactt 905101 ggaatcttgg ccataggtgc aaatcaattt acagaaggac ttaatccttt aatcgtcggt 905161 ttcctcattg tagcaatcgg tatttctctg ggaggcacca ccggctatgc tatcaatcct 905221 gcacgtgact taggtccgcg gatcgcccac gcttttcttc cgattccggg gaagggctca 905281 tcaaactgga aatacgcatg ggttccggta gtcggcccga ttttaggcgg atcattcggc 905341 ggtgtatttt acaacgctgc atttaaaggg cacatcacaa gcagcttctg gattgtaagc 905401 gttatattgg ttgtggtatt gttaggactc tatgtttata cgaaatcaca ttctgctaaa 905461 acattatcaa attctaaata tatttaatca aaggggagac atcttatgga aacgtacatt 905521 ttatccttag atcaggggac gacaagttca agagcgattc tgtttaataa agaaggcaaa 905581 attgtccact ctgctcaaaa ggaatttaca caatacttcc cgcatcctgg ctgggttgag 905641 cataatgcca atgaaatttg gggctctgtc ctcgcggtta tcgcctcagt catctctgaa 905701 tcaggaatca gcgcttctca aattgccggc atcggcatca cgaaccagcg cgagacgacg 905761 gttgtgtggg ataaagatac aggaagtcct gtctataatg caatcgtttg gcagtccaga 905821 cagacgtccg gcatttgtga ggaacttcgt gaaaaaggat ataatgataa attcagagaa 905881 aaaacagggc ttttaatcga tccttacttc tccggcacga aggtgaagtg gattttagac 905941 aatgtggaag gcgcaagaga aaaagcggaa aaaggcgagc tgctgtttgg aacgattgat 906001 acgtggctca tttggaaaat gtcaggcgga aaagcgcatg tgaccgatta ctccaatgcc 906061 tcaagaacac tgatgtttaa tatttacgat ttaaaatggg acgatgaact gctcgacatt 906121 ctaggcgtac cgaaatccat gctccctgaa gtgaagccgt cctctcatgt gtatgcggag 906181 actgttgatt atcacttctt cggaaaaaat atcccgattg ctggagcggc aggcgaccag 906241 cagtccgcat tgttcggcca ggcatgcttt gaagaaggca tggggaaaaa cacttacggc 906301 acaggatgtt tcatgctgat gaataccggg gaaaaagcaa ttaagtccga acatgggctt 906361 ttgacaacaa tcgcttgggg cattgacgga aaagtgaact atgcgttaga agggagcatt 906421 tttgtcgcag gctctgccat ccagtggctt agagacggtt tgagaatgtt ccaggattca 906481 tcgctaagcg aatcttatgc agaaaaagtg gattcaactg acggcgtgta tgttgttcca 906541 gcatttgtcg gactgggaac gccttactgg gacagcgatg tgcgcggttc ggttttcggc 906601 ctgacaagag ggacaacaaa agagcacttt atccgtgcga cactggagtc attggcttat 906661 cagaccaaag atgtgcttga cgcaatggaa gcagattcaa acatttcatt aaagacgctc 906721 cgtgtagacg gaggagctgt aaaaaacaat ttcctaatgc agttccaagg agacctgttg 906781 aatgttcctg tggagcgccc ggaaattaat gaaacgactg cacttggcgc ggcttatttg 906841 gcgggtatcg ctgtgggatt ctggaaggac cgttctgaaa tcgcgaacca gtggaatctg 906901 gataaacggt ttgagcctga attggaagaa gaaaaacgaa atgagctgta taaaggctgg 906961 caaaaagccg tgaaagcagc tatggctttt aaataaagta atactatggt ataatggtta 907021 caagttaata agaacggtcc tgagatgagg agagaccaca gcaccaaagt gtaagcatgc 907081 actttggctg ttgtggtctc tttttctatt taccgtgaca acaaggagga aacgtaatga 907141 tgaatcatca attttcaagt cttgaaagag atcgcatgct gacagacatg acgaaaaaaa 907201 catatgacct atttattatc ggaggaggaa ttacaggagc cggaacagct cttgacgcgg 907261 catcaagggg aatgaaggtc gcactaagcg aaatgcagga ctttgcggcg ggaacatcaa 907321 gccgatcaac gaagctggta catggcggct tgcgctattt aaaacaattt gaagtgaaaa 907381 tggtcgctga ggtaggaaaa gagcgggcga ttgtgtatga aaacggcccg catgtcacta 907441 caccggaatg gatgctgctt ccgtttcata aaggcggcac attcggttca tttacaacat 907501 ctattgggtt aagggtttat gacttccttg caggtgtgaa aaagtcagaa cgaagaagca 907561 tgctttcagc aaaagaaacg ctgcaaaaag agcctttggt gaaaaaagac ggcttaaaag 907621 gcggcgggta ctatgtggaa taccgcactg acgatgcgag actgaccatc gaagtcatga 907681 aggaagcggt taaattcggg gcagagcctg tgaattactc caaagtgaag gagcttcttt 907741 acgaaaaagg caaagccgtc ggcgtattaa ttgaagatgt gctgacaaag aaagaatata 907801 aagtgtatgc gaaaaaaatt gtcaatgcta caggcccttg ggtcgatcag ctcagagaaa 907861 aagaccattc gaaaaacgga aagcatttgc agcatacaaa aggcattcac cttgtatttg 907921 accagtctgt ctttccgctg aaacaggctg tatatttcga tacacctgat ggccggatgg 907981 tatttgcgat tcctcgtgaa ggcaaaacat acgtgggaac aacagacact gtttacaaag 908041 aggcgctgga gcatccgcgg atgacaacgg aggatcgtga ttatgtcatc aaatcaatca 908101 attacatgtt cccggaactg aatatcactg cgaatgacat cgaatccagc tgggcggggc 908161 tgcgtccgct gattcatgaa gaaggcaaag atccttctga aatttcacgg aaagacgaga 908221 tttggacatc tgactcaggc ctgatcacca ttgccggcgg aaaactgact ggatacagaa 908281 aaatggcgga gcacatcgtt gatcttgtcc gtgatcgctt aaaagaagag ggcgaaaagg 908341 attttggacc atgtaaaacg aaaaacatgc caatctctgg cgggcacgtc ggcggttcga 908401 aaaatcttat gtccttcgtt accgcgaaaa caaaagaagg aattgcagcc ggtttatcag 908461 aaaaagacgc aaaacagctt gcgatcagat acggctctaa cgtagatcgc gtctttgacc 908521 gggtagaagc gctgaaagat gaggccgcga aacgcaacat tccggttcat attcttgctg 908581 aggcagaata cagtatagaa gaagagatga ctgcaacccc tgctgacttc tttgtccgca 908641 gaacgggacg tttatttttt gatatcaatt gggtaagaac atataaagat gccgttattg 908701 attttatgag cgagcgattc caatgggatg agcaggcgaa aaacaaacat acagaaaacc 908761 tcaacaagct tttacacgat gcggtcgtac cgcttgagca ataaatcata acgggctgtc 908821 tgcagcccgt tatttctttt tacgtgccga aagggggaga tctcaggtta tcaagtgaca 908881 gaggcacccg cttcatataa aataatggca taagctgata cataggagga cgaatatgac 908941 ttggagaaag agctatgaac gctggaaaca gacagaacat ttagatctgg aattaaaaga 909001 gcgccttatt gaattagagg gagatgaaca ggcccttgag gactgtttct ataaagacct 909061 tgaattcggt accggcggaa tgcgcgggga aatcggcgcc gggacaaatc ggatgaatat 909121 ttacactgtg cgcaaagcat cggccgggtt tgcggcatac atctcgaagc aaggtgagga 909181 agcgaaaaaa cggggcgttg tcattgctta tgattcccgc cataagtctc cggagttcgc 909241 gatggaagcg gcaaaaacac ttgcgacaca aggcatccaa acatacgtgt ttgatgagct 909301 tcgcccgacg ccagagctgt cattcgctgt tagacagctg aacgcttatg gtggaattgt 909361 ggtaacggca agccataacc cgcctgaata taacggctac aaagtatacg gggatgatgg 909421 cggccagctg cctccaaagg aagcggacat cgtcattgag caggtaaacg cgattgaaaa 909481 tgagctgacg atcacagtgg acgaagaaaa taagttaaaa gaaaaaggct taatcaaaat 909541 catcggtgaa gatattgata aagtttatac agaaaaactg acgtccattt ctgtacatcc 909601 tgaattatcg gaagaagtag atgtaaaggt tgttttcaca ccgctgcatg gaactgcaaa 909661 taaaccggtc agacgcggtc ttgaagcact cggctacaaa aatgtaacgg ttgtcaaaga 909721 acaggaactg ccggattcaa acttctccac tgttacatcg ccgaacccgg aagagcatgc 909781 ggcattcgaa tatgccatta agcttgggga ggagcagaat gcagatattc tcatcgcgac 909841 agatcctgat gctgaccgcc tcggcatcgc ggtgaaaaac gatcaaggca aatatacagt 909901 gctgacagga aaccaaaccg gagcgttgct gcttcattac ctgctttctg aaaagaaaaa 909961 acaaggcatc ctgcctgata acggtgttgt tctcaaaacg atcgtcacaa gcgaaatcgg 910021 ccgtgctgta gcttcttcat tcggccttga tacgattgat acgctgacag gctttaagtt 910081 tatcggtgaa aagattaagg aatacgaagc atcaggccag tataccttcc aattcggtta 910141 tgaagagagc tacggttatt taatcgggga ttttgcccgc gataaggacg ccattcaggc 910201 tgcgcttttg gcagttgaag tttgcgcgtt ctataaaaaa cagggaatgt cattgtatga 910261 ggcgctcatc aatctcttta acgaatatgg tttttatcgt gaagggctga aatccctgac 910321 gctgaaaggc aaacaaggag cagagcaaat tgaagcgatt cttgcttcct tcagacaaaa 910381 tccgccgcag aaaatggcgg gcaaacaggt tgtcacagca gaagattacg ctgtaagcaa 910441 acggacgctt ctgactgaaa gcaaagaaga agccatcgac ttgccaaaat caaatgtatt 910501 gaaatacttc ctggaagacg ggtcttggtt ctgtctccgt ccttctggaa ctgagccgaa 910561 ggttaaattt tatttcgccg taaaagggtc atctttggaa gacagtgaaa agcgacttgc 910621 cgtcctttct gaagatgtaa tgaagacggt ggatgaaatt gttgagtcaa cagcaaaata 910681 attcaagtat gagctgggtc attgtaaatg atccggcttt ttctttttct catccaaaag 910741 tctgaaagaa aatcatccta caagtgaagc aatgaaatac aaaaaactgg tataatctta 910801 aatacaagat caatgccgga gtgagaaacg tgagcaaaac gaggatggaa aaattaaaaa 910861 cgctgaaaac gattgcggaa accttaaatc aagggcacga tatcaaagca acactggatg 910921 aggttttaaa agagttgctg agtctgacaa accttcaatc cggatggatt tttctgatcg 910981 aagaagatgg gtcttatacg ttagcggccg acgcttatct gcccccggct ttaagccgca 911041 aggaaaaagt gctgatgtgc gaaggggagt gttactgcct gacgaaattc aataacggag 911101 ggcttagaaa agctgcaaat atcatgaact gcaaacgcat cgaatcagca gaaaacctgc 911161 attgttttga cacagaaggg attacgcatc atgcaactgt gcctttagaa gacggggaca 911221 gaagattcgg attgttaaat gtagcggcgg ccggaaaaac catgtttgat gaggaagagc 911281 tgcatttact cgagtctgtc gcctttcaga tcggaacggc aatccagcgt atgaggcttt 911341 ctgaatatca acaaaaaaat gctcttttaa tggagcgtaa ccgcctcgct caggagcttc 911401 acgattcagt caatcaaatg ctgttttccg tcagtttaac tgccaaagct gcgaagacac 911461 taacaaaaga tgaaaattta cagcagatga ttgatttcat ccaaaaccta tcacaggacg 911521 cgctcgcaga aatgaaagcg ttaatttggc agcttcgccc cggaggattg gaaaaagggc 911581 tggctgaagc cattaaaagc tatggtgcgc tcattggatt gaagatcatt tttacacaaa 911641 aaggctgtcc tgttctgact gatgagcagg agcatatgct atggcgtgtc gtacaggaag 911701 ctttaaataa ctgcaaaaag catgccggaa cggatacggc gtatgttagt ctgactgctt 911761 ctttgtgcca tgcggagctg gatatcatcg atcatggggc aggatttcgc tatgaagcgc 911821 atgccggtct gccttcactt ggcataaaag gtatgaaaga gcgagcggaa aaagccggag 911881 ctaagttttg gattgagtca gcgcttggaa ctggaacaaa gctgtccatc aggcttccgc 911941 taaaaagccg aaaaggaggg gcggtatgaa aattgtcatt gctgatgatc atcatgttgt 912001 cagaaagggt ctgcgttttt tctttgccac ccaggatgat attgaagtcg tcggagaagc 912061 tgcaactgga ttagaagccc tccgtgtcat cgaagagaca aagccggatc ttgtgctaat 912121 ggatttgtct atgcccgaga tggacggcat tcaagccatt aaaaaagcaa tacagcaatt 912181 tccggatacg aatatcattg tgctgacgag ctactctgat caggagcacg tcatccccgc 912241 gcttcaggca ggcgcgaagg cgtatcaatt aaaggatacg gagcccgagg aattggtgaa 912301 aacacgacaa gtgcatggtg gcgaatacaa gctttctaca gctattatgc cccatgtgct 912361 gacacatatg aaaaatcagc acgacccgga aaaagaaaaa tactatcaat taactagaag 912421 ggaaaaagac gttctgactg aaatagcgaa cgggaaaagc aataaagaaa tcgcagcagc 912481 cttgtttatt tcagaaaaaa cagtaaaaac ccatgtatcg aatcttttag caaaacttga 912541 agtggccgat cgcacgcaag cagcgctttt cgcagtgaaa tataacctga atggagagat 912601 ctcaaaatga acatgttagt cataaatggc acgccaagaa aacatggcag aacaagaatt 912661 gcagcatcct atattgcagc tctgtatcac acggatttga ttgatctaag cgagtttgta 912721 ttgcccgttt ttaacggtga agcggaacaa tctgaactgt tgaaagtaca ggagcttaag 912781 caacgcgtta cgaaagcgga tgcgattgta ttattatcgc ctgaatatca cagcggcatg 912841 agcggcgctt taaaaaatgc cttggatttt ctaagcagcg aacaattcaa atataagccc 912901 gttgcattat tggcagtagc gggaggcgga aaaggcggca tcaatgcgct gaacaatatg 912961 agaactgtga tgcggggtgt ctacgccaat gtcattccga agcagctggt gcttgatccg 913021 gtgcatattg atgttgaaaa tgctacagtg gctgaaaaca ttaaggaaag cataaaagag 913081 cttgtcgaag aactcagcat gttcgcaaaa gcaggaaatc ccggcgtcta aacgccggga 913141 tttgtttatg tgagaagggc tatttgatct tcataagtca gctctgtggc atgatcaata 913201 tatcggagaa gggaatacag catcttttct aaaacggcgt aatcctgttc aaaatgatac 913261 gcatgcagaa aatgctcaat tcgttttgat aacaaatcgt cctctgtacg caccattaaa 913321 attaataaat tatcccattg agaacgatgg gtgtaataaa gcgctttatc gtaatcggca 913381 taatccatga atcgcttctc ctttcttggg tgagaagttc atgattagtt tatgccgcat 913441 cctctgttat tgacggggca aaacttgccg tctgcgtcag taaaggggta gcaatatgag 913501 ggagacataa aatcaaaatg cctgaatgaa gatatcgctt ttggtaaacc tatgagggaa 913561 tatattctgg gtacaggaga ctgaaaaaat gaaatccctg ccgtatacca tcgcacttct 913621 tttttgcgga ttgattatcg tgtcaatggc tgcaaaaggt cattcaacgg acacagacga 913681 gtccgttcaa aagtgggaac agcttgcctg gagcaaaatt caggatgaat ataagggcgc 913741 ttcattttct gattatgctt atatggggcg tacagaggtg aatgatcagc agactaaaga 913801 tgtctttcgg gtgacagtca gacagaaaga tgacactttt tctgttcggg ccgaagtcta 913861 ttttcatccg gtgacaaatc atatgatcag catcaacgtc tttaggctct aataaaaaac 913921 tgtacagccg ttaaggccgc acagtttctg tttttagaaa tatcgttttg caccgagata 913981 gcgctgtttc cagtaagagt tgttcatatt ggaaatgaca actccggaat cgttggcatt 914041 tatgaattcc ccgttgccta ggtaaattcc gacgtgggaa gggccggctt tatatgttga 914101 aaagaaaacg aaatctccga cagcaggctg gctaactgat ttcattgtgt tccaatatcc 914161 cgctgccgtt aatctagata cggatgtgac tttgttcagt acatagtaaa tgaatccgct 914221 gcagtcaaac ccggacggtg tcgtgcctcc ccagcgatac ggaaccccaa gctgcgcttt 914281 agcggccgaa atcattgtgt taatcttcgc actcgttgag ctggtggtgt ttgaagaacc 914341 ggatgaagac gatgatgaag cttttccgga aatgaccagc ttttggccaa cctgcaagac 914401 atccgttttt aaattgtttt tctcacgaat ctgctgagct gttacattaa atttttgagc 914461 aatcacccat aaggaatcac cgcttttcac cgtgtatgta gtcgtcgtgc cggagcttgc 914521 atttgacgaa gaagacgacg atgatgaaga gcctgaagat gctttacctg tcagcttcaa 914581 tacttgtcca acgtaaagca catctgattt cagattgttg atatttcgga tttgctgtac 914641 agtcaggtta tagttgtttg cgattttcca aagtgaatca ccgcttttaa cggtatattt 914701 agttgttgct gaagtttggt tcgatttgga tgaattgtct ttagaagacg tatcagagcc 914761 gcttgatttt gttttcaaca cctgattcac gtaaatggtg tctgatttta agttgttcaa 914821 gaccttcaat tcagcgatgg acatattgac tttgtttgca attttccaaa gtgaatctcc 914881 aagctgcacc ttatatgttc ccgtagaaga tgaagaactt gaactcttat tagaactgct 914941 ttttgaactg gagcttgaac tcttattaga gttgcttttt ttactggaac tagagcttga 915001 agaaacagta ccggacacct ttaatttctg cccagcacga attaaatcgc tgcttagtcc 915061 gtttaatttt ttcagttcct gcaccgtcat tttaaactca tttgcgatca gccaaagtga 915121 atctccgctt ttcactgtgt aaacagaact tccgctcttc ttggttgttg agcttgaagt 915181 agatgaagaa gtgctggatt tgctgcctgg aatagtaagc gtctggccga tcgacagaac 915241 agtagtcgaa agatgattgg cggatgtgag ggccgccaca cttgtgttat aggtttgggc 915301 cagtttccat aaagaatctc cgcttttgac cttaatcgtt gctgcttcag ctggtgtcac 915361 tactaaagtt gtgccgacaa tcgcagatgc tgtcagccct gctgctaatt tctttttcat 915421 cttagctctc ctttttcccc caatgatttt gcatttgctg tttctttttt atatcggcac 915481 atttgtctca tcgttttgcc tttttataaa aatagccaaa ttatcttaac aataaggggg 915541 aaaaagggca taaaaaaaga aggaatctta atctattcct tcatttttaa aagcttcatg 915601 atatcttctt tgtttttgac gaggtcgcgc agtgtgtatt tgtctaaaac tgcgaggtag 915661 gctaaaagcg cttcattcag cacatgtttt aagccgcaaa ccggggaaat aacacagaga 915721 ttcttgttcg catcaaaaca ttcaacaata ttaaaatcgt cctccgtttt tctgacaacc 915781 tcaccgatgt tgatgtcttc agggtccatg cctaatcgta tgccgccgcc ccgtccgcgt 915841 atcgtttcta cgtagccgag ctggccgagc ctgtatatga ctttcatgag atgatttttt 915901 gaaatagaat acgtttcggc aatctgtttt atatttgaaa gttctccggg acgctctgca 915961 gccagaaaaa tcaacactct taatgaataa tctgtataat tggttaactt cataataaga 916021 cctcagaata agacattttc tatatcttat cataatcgat tgaaaaatga aaaaaaagga 916081 attaaaaaac atgcacccag ctgggtgcat gttttttgct tacatgtcat tcggcggatt 916141 ttggttttta cggttttttt cgatttctgt gttttgcatt ttgcgttcaa atgtagacag 916201 ataacgtgat gcaaaatcct taccgccaag gccgaaggat aaaccaaaag caagtgcgaa 916261 gccgctaaga acgatgatga acgcggaatt gacgattgtc gcagcgacac ccagctgatc 916321 cagggccata aagaaagcaa gtgcgataat cgtatattta gcaataggcg ctaaagactt 916381 gaattcctga ccttttatca tgcttgcgag cacttttctc accaattctc ctgcgtaaag 916441 gccgagtccg agaatgaata ctgcgacaag gacattcggc agatacgcga tgatgccggt 916501 ggcaatttct acgaggaagt gcagccgaac aatttgaagc gcctcagctg taaagagcag 916561 aatgacaatg atttgcgcaa tcataccgac aacttgagac aaggacagct ttgcaggcgt 916621 tccggcttcc atgcccattt tccctaagac agaatcaaag cctgcgcgat ggagcagtcc 916681 ggacaccatg gatttcaccc attttcctgc ccagataccc gctaatacaa gcacgatggc 916741 aatcatgatg ttcggaagca tgtttaaaat cgtattcagc atagagacag ctggttttga 916801 aatgccggcg acatccagct gatcaagcgc tgaaatgacc accggaatca taatgagcac 916861 ataagcgatt gttccgatga ctgctgaaag gcttgtgtct tttaagtaaa ttgataaacc 916921 catacgtgcc gcgaatcttt cggtgccgat gcttgcaagg aaattcgtaa tgatatcacg 916981 gacaaggcgg gcaacaagcc atccgattaa tacgataagc gccgctgcaa ataatttcgg 917041 cagaaaagcg agcacgcttt ccatcatatt tgtaaaagga cctgaaatgc cgctgatttt 917101 caaagaagat aagacccctg gcagaaaaac aagcagcacg agataaaaga caatttgtga 917161 agcggtattg acagcctggt gaatatcttt tccttcagac accaaattcc acttgcgcag 917221 tttgtcactc gtgttcagct tcatcccgat ttttttgaca aggaagctca aaacagaagc 917281 tgcagcccat cctaacagca gaatgagtcc ggctttcagc acgcttggga tcgcagctgc 917341 aatcgccgaa agcatactga caaacggcga tgccactgtt gtcaggtgca aaatgttaaa 917401 gaataaaata aagacgatga tcagtgcgat aaaataaacg accttgctta tgactttttc 917461 cgaggaatag cgtgaaggct ttttcccagc aaagagcttg tcgtcgattt ttgttttgct 917521 gagtcctttg tataccgctt tttcaatgat tttagcaata gcccagccga ttaataagac 917581 gagtaaagca atgattacgt ttggcagctt actgagataa gaagaaaaca cgtctgctac 917641 attcaattgg tatcgctcct ttttcgtagt atggtgtgtg tttacccact tatccaataa 917701 gcaaacagat gaatgtgccg ggggaatttt ttcttgcccg agtgagacta tcatcttttg 917761 tctggcgggc tcatacatta tagataagtc caagtagggg ggattcggtt gaacgcggag 917821 gagaagaagg gattacagcg ggcaattgag gaaattaccg aaattgcaaa aggattcggc 917881 cttgatttct acccgatgag atatgaaatc tgcccggctg aaattattta tacatttggc 917941 gcgtacggga tgccgacaag attcagccac tggagcttcg gcaagcagtt tcacaagatg 918001 aagctgcact atgatctagg gttaagtaag atctatgagc tggtcattaa ctcagatcca 918061 tgctacgctt ttttgctgga cagcaactca ctgatccaaa ataaattgat tgtcgcacac 918121 gttcttgctc attgcgattt cttcaaaaac aactgccgtt tccaaaacac gaagcgcgat 918181 atggtggaaa gcatggcggc aacagctgaa cggataaaac actatgaaca ggttcacggg 918241 ataaaagaag tcgaatcttt tttagatgca atcctttcga ttcaggagca tatcgatccg 918301 tcgttggtcc gaccaaagct ccaatggagt gtggatgatg aggaagagga gattgaagag 918361 gcagccacgc cttacgatga tctatggtct ttagatgaaa agaaaccgaa aaaacaagtg 918421 aaaaaatcga aaaaaccgtt cccgccgcgg cctgaaaaag atatcctgct ttttatcgag 918481 gagcattccc gggagctgga gccatggcag cgtgatatat taacgatgat gagagaggaa 918541 atgctttatt tctggcctca gctggaaacc aagattatga atgagggctg ggcttcctat 918601 tggcaccaga gaattatacg tgagcttgat ttaacctctg atgaagcgat cgagttcgcc 918661 aagctgaatg caggtgtcgt tcagccgtcc aaaacaggca ttaatcctta ttatttaggg 918721 ctgaaaatat ttgaagacat tgaaaagagg tacaacaacc cgacggagga aatgaagaaa 918781 atgggcgtgc agcctgactc cggccgggag aaaatgtttg aggtcaggga gattgaatcc 918841 gatatctctt tcatccgcaa ttatttaacc aaagaattag tcatgcgcga ggatctttat 918901 ttgtttcaaa aacagggccg agattataaa atcatcgata aacagtggaa gtcggtgcgc 918961 gaccagctcg taagcatgcg ggtaaatggc ggttttccat atttgacagt aaacgacggc 919021 gattatatga aaaataacga actctatatt aagcattggt atgagggcat agagttggat 919081 ttgaaatatt tggagaaagt gcttccttat ttattccagc tttggggaag aagcgtgcac 919141 attgagtctg tgcttgagga taaggaagtc atgttttcgt acgacggaaa aggtgttcac 919201 cgcagatatt tataaaaaag aggatgcagc gttctgcatc ctttttattt tccagttttt 919261 aaaatcttaa atatgatgtt tgcctggtcc gtattgttaa tcaatccgcg gaatttttct 919321 tttccggggc cgtacgcgta taccggtact tcttcgccgg tatgatcggt actcgtccat 919381 ccgctgttgg agcgggtatt aaaaatcttg atgatggctt tggaggcccc tttgcttttg 919441 tcagcctgtg cagctgcttc aacgcttttg atttcttcag atgtgacttt cagattggca 919501 tagcgggcga gcacatcttt aaccggcttg ccttcactga tttttttggc catgaattca 919561 ggtgttttct tagcggagag aatcggttct gcgtgccaat tcttttcccc gtttgcgcca 919621 atggtaaagc cgccggttgt atggtcagca gttgcaatca caagtgtatg tttgtctttt 919681 ttcgcaaatt caatcgcggc tttataggcc tgttcaaaat ctttaacctc gctcatggct 919741 cctactgtat cattgtcatg ggccgcccag tcaatctggc tcccttcgac catcaagaaa 919801 aatccttttt tattttggtt caggcgatca attgctgaaa ccgtcatgtc tttgagagac 919861 ggtgttttac tgtcacggtc gagcgcttta gcaagccctc catctgcgaa aagcccgagc 919921 acctgctgat ctttattttt tttcaatgct tgtttagttg tcacatagct gtagccggct 919981 tgtttgaatt cctttgtcaa gtttctgtcc ttgcggttaa aataagattt tccgccgccg 920041 agcagcacgt ctattttatg tttgcctttt atcttgtcat ccatatagct gttggcgatt 920101 tggtccatgt ttttccgtga ttcattgtgg gcgccatatg cggctggagt ggcgtggtta 920161 atttcagacg tggcgacaag ccctgttgac ttgccttgct gtttggcctc ttcaagtaca 920221 gatttcactt tttttccgtt tttatcgacg ccaattgcat tgttatatgt cttaacgcct 920281 gtcgctaatg ctgttccggc tgctgctgaa tctgtaatat tatagtcagg gtcatccgga 920341 tgcgtcatca tcatgcctgt caggttccgg tcaaattctg ttaacttcgg gttattcggt 920401 gtgtcaccgt tatttttcat ggaacggtag gctcttatgt aaggcgtccc catgccgtcg 920461 cctatcatca caatgacatt tctgatctca gctttgtctt gttttttggc gctggccttt 920521 tctgtttgct gaagctcagc tccggcaaag attccagctg taaggacaga aacagcggcg 920581 attggcagaa gttttgattt catattttga aacaaactca tttttttcat gcctccttta 920641 atgtattccg tttatcatgt tagggaaact ttgttaaatg cggctgttga tcatgtaaac 920701 aataagtaaa gccttgtaag gaaatgaaaa aacgcttttc gttatcttgc cttatttgat 920761 gtaaagcatt catttttcag aaaaatcttt acctctctgt ctttgcatga tatgtttgtt 920821 taaataaaaa aactgcggat aaccacagct ctcctcgaat atactttatc actcattttt 920881 ccgatatatg agccgacccc gaaagttttt catttatttc ctttatgttg aaaaacatcc 920941 cataaaacat gacaaaagca ctcgtttttt gtcacctttg caatgaaaat gaaatattta 921001 atacccttaa aaactttttt ttagaacgaa taattaagaa atttgtcaca tgaagtcaag 921061 actatttctg atgggaatct atccttataa tagaaatcaa taagattaat ttaaaaaaag 921121 agatacatat atatagagtt aacatttggg gaggaaaata tgaaaaagca aatcattaca 921181 gctacgacag cagttgtttt aggatcgacg ttatttgcag gagcggcatc tgcacaaagc 921241 attaaggtga aaaaaggcga cacgttatgg gatctttcaa gaaaatacga cacaacgatc 921301 agtaaaatta aatcagagaa ccaccttcgt tcagacatta tttatgtggg acaaacttta 921361 tcgattaacg gcaaatctac aagttcaaaa agcagcagtt cttcttcctc ttcttctaca 921421 tacaaagtaa agagcgggga cagcctttgg aaaatttcaa aaaaatacgg catgacaatc 921481 aatgaactga agaagctgaa tggcttaaaa tcagatttgc ttcgtgttgg acaagtcctg 921541 aaactgaaag gttcaactag ttcaagcagc tccagctcat caaaagtgtc atcgtcttca 921601 acttctactt ataaagtgaa gagcggagac agcctttcta aaattgcgag caaatacggc 921661 actacggtta gcaaattaaa aagcttaaac ggcttaaaat cagatgtaat ctatgtcaac 921721 caagtattga aggtgaaagg aacaagcaca agcagctcaa aacctgcttc atcttcatcg 921781 tcttcaagca gcaaaacgtc atctacatca cttaatgtga gcaagctggt ttctgatgca 921841 aaagcgttag tcggaacgcc atataaatgg ggcggaacga caacttcagg ctttgactgc 921901 agcggattca tttggtacgt actgaataaa caaacaagtg tgggcagaac aagcactgca 921961 ggatactgga gttctatgaa gagcattgcc agcccgtctg ttggtgattt cgtcttcttc 922021 acaacatata aatccggccc ttctcacatg gggatttaca ttggaaacaa cagtttcatt 922081 catgcaggat ctgacggcgt acaaatcagc agcctgaaca acagctactg gaagcctcgt 922141 tacctcggtg cgaaaagatt ctaattttta gagaaaaccc gttcattgga acgggttttt 922201 ttcattagac ggagcacagg cgttttggtt gctcctaaaa atgaaaatgt gataaaaaat 922261 ccaagaactt tttttctttc ttattttcat aaagggcaat cgcgtaagcg ccggcatagg 922321 gcagctgtac agactgataa ggaattctga tcatctgttt ctctgctaac tcacgcttta 922381 ctgtagataa aggcagaaat gaaactccga gtccttcctt gataaaccgt ttcgttatat 922441 gtgtttgagt gaccttcatt gttctcacaa atggaaatgt cattctgact tgacggagca 922501 agtcgtccca gtaatcagga tgattgtggg tcaaaagcag gtattgttcg agcacctctt 922561 tggcatcaat ttcgttgtct tctatgaaac gcttatcggg cggggcaaca aggacgacag 922621 ggtctttgta taagcagtgg cagcttaaag aagaagactg tacctttaaa cagcttagtc 922681 cgatatctgc ttccccggct ttaatcagtg acgcgatttc cgctgattcg aaaatcgtaa 922741 ccgccatttc tgtttccgta ttcattgctg tgtaccgctt catgacagaa ggaagcactg 922801 tatctgcaat aagcggagaa accgcgagct gtaaggtttg agagtagcct tgtctcactc 922861 tgtgaagctc tgccatgctg ttttcataat catcaagaag cctgagcgca tacggcaaat 922921 acgccctgcc ttcatcagtc agctggattt gcctgccttt acgctcgaac agcttgcagc 922981 tgatttcttt ttctaattgc ttgatatgta cggtcacagt aggctgagat aagaaaagcg 923041 tttccgccgt ttttcggaag ttctcatatt ttgcagcggt cacaaaggtg tgaagccatt 923101 tgaaatccat ttctattctc cctctgatta atatttttaa ttaattccct ttaaaatatt 923161 gattattttt taaatattat atttactata ataacagaaa aggatagggg gaatacaaat 923221 ggtacattac ggattaaagg gaattacatg tgtagaaaca tccatcagcc atattgatgg 923281 tgaaaaaggg cgtctgattt acagaggaca tcatgcaaaa gacatcgcac tgaatcacag 923341 ctttgaagaa gcggcttatt tgattttatt tggaaaactg ccttcaactg aagaattgca 923401 ggtatttaaa gataagctgg ctgcggaacg gaatcttccg gaacatattg agcgcttgat 923461 tcaatcactg ccaaacaaca tggacgatat gtcggtgctg agaacggttg tttcagcatt 923521 gggggaaaat acgtacacat tccatccgaa aacagaggaa gcaatccggc tgattgcaat 923581 cacgccttct atcattgcat acagaaaaag atggacgcgc ggtgaacaag caattgcacc 923641 ttcttcccag tacggacatg tcgaaaacta ctattatatg ctcacaggtg aacagccttc 923701 agaggcaaaa aagaaagcgc ttgaaaccta tatgattctg gccacggagc acggcatgaa 923761 cgcatcgact ttttcggcac gagtcacgtt atctacagag agtgatttag tgtcagccgt 923821 cacggctgct ctcggtacga tgaaaggtcc gctgcacgga ggtgctcctt ctgcggtgac 923881 aaaaatgctt gaagacattg gagaaaagga acatgctgaa gcatatctga aagaaaaact 923941 cgaaaaagga gagcgcttga tgggattcgg ccacagggtg tacaaaacaa aagacccgcg 924001 ggcagaagct ttgagacaga aagcagaaga ggtggccggc aatgaccgtg atcttgatct 924061 tgcgctgcat gtagaagcag aagcgattcg tttgctagaa atctacaaac cgggacgaaa 924121 gctgtacaca aatgttgaat tttacgcagc tgcagtgatg agggccatcg attttgacga 924181 tgaattgttt actccgacct tttcagcaag ccgaatggta gggtggtgcg cccatgtact 924241 ggaacaggca gaaaacaaca tgattttccg cccgtcagcg caatataccg gtgccattcc 924301 cgaggaagtt ctttcataac atattttggc gtttattcat ttctgtcgtg tggtaacgtt 924361 cagtatcaac cacatgtcta ggagtgatga atgtgaaccc aatggacaga caaacagaag 924421 gacaagaacc gcagcatcag gacagacagc cgggcattga gtcaaaaatg aatccgctgc 924481 cgctgtcaga ggacgaggat tatcgaggaa gcggaaaact gaaaggaaaa gttgcgatca 924541 ttactggagg cgacagcgga atagggagag cagcagctat tgcctttgct aaagaggggg 924601 ctgatatctc cattctatac ttagacgagc attcggacgc agaggaaaca cgcaaacgga 924661 tcgaaaagga gaatgtccgc tgcctgctta tcccgggaga tgttggggac gagaaccatt 924721 gtgaacaagc tgtgcagcaa acagtggacc attttggtaa actcgatatc ttagtgaaca 924781 acgccgctga acagcatccc caggacagca ttctcaatat ttcaacagaa cagctggaaa 924841 aaacctttcg cacaaatatt ttttccatgt ttcatatgac gaagaaagct ttgcctcacc 924901 tgcaagaggg gtgtgccatt attaatacga catcgattac cgcttatgaa ggggatacgg 924961 cgttaattga ttattccagc acaaagggtg cgattgtttc ctttacgcgt tccatggcga 925021 agtcgcttgc agataaaggc atcagagtga atgcggtggc gcccggtccg atttggacac 925081 cgcttattcc ggcgacattc cctgaggaaa aagtgaaaca gcacggcttg gataccccaa 925141 tgggaagacc gggacagccg gttgagcatg caggcgccta tgttctgctg gcgtctgacg 925201 aatcttccta tatgacaggg cagaccattc atgtgaatgg cggccgtttt atttcaacgt 925261 aatcaacgaa aaaccagctc aagagctggt tttttgtgtg gtgaaaaatt tcaaaataaa 925321 aaatttgtcg atttttctaa caattttgtt ttcatttttg caattttata tataatattg 925381 agtaggagaa aggaatgatt cgcgaccagt acaaatatag tagaaaaaaa agaataatga 925441 ccattgttac tcatgaattc agaaaattca aataaaatat ataaaaatag atgatcggga 925501 gttgaagggg aatgaaaggg agcgttttta ggaagaaaag cattcaggat ttaatcgctg 925561 cgacgagcgg ggaaaagtct ttaaaaagag aattaggggc atttgattta acgttgcttg 925621 gaatcggcgc cattattggc acagggattt ttgttctgac gggaacaggc gcagtcacgg 925681 ccggtcccgg gctgacgatt tcatttgttg tggcggcgtt ggcttgttta ttcgccgccc 925741 tgtcttacgc ggaatttgcg tcaagtgtgc ctgtttcagg ttcggtgtat acattcactt 925801 atgcgacatt gggagagctt atggccttta ttatcgggtg ggatttaatt ttagaataca 925861 tgctggcggt aagtgcagtg tcggtcggct ggtctggtta tttccaatcg tttttatcag 925921 ggcttggcat tcatcttccg gttgctttaa cagcggcacc gggcgcagtg aaaggcacct 925981 ttaccctgtt taatcttcct gcattcgtca ttgtaatggc gatcacatat ttgctttatt 926041 taggcatcaa agaatcaaaa agagtcaaca atatcatggt tatcttgaag atactggttg 926101 ttctgctgtt tatcgcggtg gcagccgttt acgtgaagcc gcacaactgg cagccgttta 926161 tgccaatggg ctttggcggc gtgttcagtg cagcggcgct cgtattcttt gcttttatcg 926221 gatttgacgc tgtatcctct gctgcggaag aaacgaaaaa tcccgcgaag gatctgccta 926281 aaggcattat tttctcttta ctggtctgca cgattttata tgtcaccgta tcagccatca 926341 tgactggggt tatcccgttt gctcaatttg cgggtgtgga tcatccggtt tctcttgttc 926401 ttcaaagcgc agggcaaaat tgggtggcag gcatcattga tattggcgcc gtgttgggaa 926461 tgacaacagt tatgctcgtg atgctttacg ggcagacccg cgtcatgttt gccatgtcgc 926521 gtgacggact tgtgccgggt tcactttcta aagtgcatcc aaagcacaaa acaccttatg 926581 tagccacttg gtttttcgga acgatgtcgg cgcttctcgg ctcacttgtt ccgctggatg 926641 aacttgcaaa gctggtgaac atcgggacgt tgtcggcatt tgtcctgatt tctgtggcag 926701 ttatcgtttt gagaaagaaa cagcctgatc ttccgagagc ttttaaatgc ccgggagttc 926761 ccgtgatccc aggcctggcg attctgttct gcctgttctt gattttaaat ctgggatggg 926821 tgacgattgt ccgcttccta gtgtggctgt taatcggctt ggtaatctat ttcctgtatt 926881 caagaaagca ttcaaaatta aatcaataac cttttgataa agagagcggc catacaggcc 926941 gcctcttttc tgttcttggc aaatgaatct atagaaatga agacaaaaat aagagataat 927001 ataggctgga aaggaagtga cgtttattgt ctgagcaaaa accagtccaa tgggcttcga 927061 aaattggttt cgtcatggca gcggccggct cggctatcgg cttgggcgcg atttggaagt 927121 tcccttacgt agcggggacc aatgggggag gagccttttt tcttatcttc gtgttattta 927181 ccatcctctt aggctatccg cttttggtgg gggaatttat ttttggaaga cggaaccaga 927241 cgaatgccat tgatgcatat aaaaaagaag cgccgcgatc agcttggttt cttacggggt 927301 ggatcggcgt agcggcgtgt ttcttagtgc tgtcgtttta cagtgtaatc gggggatgga 927361 ttttgctgta tatcgtgaaa acagcgtcag gatcactgtc cgggctttct caagcacagt 927421 atggcgctct ttttgcttct attatccaaa atccggtgca gacgctcgcg gctcagcttg 927481 tctttatggc actgactgta ctcgttgtcg caagaggggt tcaaaaaggg attgaacggg 927541 taagcgcggt gatgatgccg attttgtttt tattgtttat tctgctcgtt cttcggtctc 927601 ttacgcttaa tggtgcaatg gaaggcgtaa agtttctgct tgtgcctcat ttcggcgatc 927661 tgactccgga atccatatta ttcgcgctgg gacaggcctt ctttacgtta acactggggg 927721 tttcggtgat ggtgacctac agctcctatt tgccgaaaac acaaaatatc cctcgttcgg 927781 cagcctccat tgtcttgatg aatatcattg tgacactctt ggcaggtttg gctatttttc 927841 cggcggtttt ctcattcggt tttcagccaa atgaaggacc gacattgctg tttacagtgc 927901 ttccggccgt ttttgaacag cttccgttcg gcacattgtt ttttatcggc tttctcgttg 927961 catttttatt tgcagcctta acctcagcat tttcgatggt tgaaattatc gttgccacaa 928021 tcggaaaagg ggacgaaaag aagagaaaaa aactgtcatg gacgagcggg cttttgatct 928081 ttttggtcgg aatcccatgc tgcttgtctt atggcgtttt gagtgatgtg cacctatttg 928141 gcaaaacgtt ttttgatatt gccgatttta ccgtcagcaa tgttttgatg ccttcaggcg 928201 ctctgttaat ttctctattt atcccgctga aaatttcgaa aagcgaactc ttggctgaaa 928261 tgcgaaatgg atcaaatgca ggtaaagcat tcttttacac atggttttat ttgcttcgtt 928321 ttatcgtgcc gcttgccatt attatcgtgt tcttaaattt aatcggaatt ttatcatttt 928381 aaaaaacagg ctccgtttcc ggggcctgtt ttttatttaa taagatgata tcaacggtgc 928441 ccatgccgtt ttcagttttt ggatgccgag cctgatgtcc tcttctgaca aaccgccata 928501 accgattaag acagaagtaa aaggcgtctg ttctatatat gagggagaca cgggatagag 928561 ggttacaccg tggtcagcgg ctgcttgtat tgcttcttcc tcacttgctg gaaacaaaag 928621 gcgcagcaga atgtgaagcc ccgagttctt accgagaatc tcaacggtgt ttcccagttc 928681 agagcgaatg gcttctaaca ggacagcgtg tttttttcgg tataagcttc tcattctatt 928741 tatgtgtttt tgccactctc cggtttcgat gaagtctgcc agtgccaatt gcgagtgggc 928801 agaaacggtc tgcttcatta actgaacatt gttttggatc ggttccatga gttcaggggg 928861 cacaatcatg aagctgagcc gcaaggaagg cagaagtgac tttgaaaaag tgcccagata 928921 tatgactctg ccattcggat caagaccctg taaagacgga atgggatggc cgctgtagcg 928981 aaattctcca tcgtaatcat cttctataat gaatgaattt gtttctgccg cccatgccag 929041 cagctcctgt ctgcgggtaa tcgtcataat ggtcccaatc ggaaactgat gcgaaggagt 929101 cgtatacatg agataaggat tctgacggta gagctcatcc ggcaggacgc cttctgcatc 929161 agaacaaatc ggagtgacat ccatgtgatt tgcttcaaac atccttcttg aacggtgaaa 929221 gcccggttct tcaaagccga tttttgtacc tggctttagc gaaaggcaaa gattttgcag 929281 aagcacggtg gttcctgcgc cgatgataat ctggccgggt tcacaattta ctccccgaga 929341 cagcctgacg aatcgggcaa tcatgtgcct gagttcgtat tctccttgag ggtcgccaga 929401 ggtgtgaaac gatccggaat agcgatcaag actttttact atgctttttc tccatgcgtt 929461 aaagggaaag agggtcggat caacgctgcc ctgatggaag tcaatagcag gtgcgttttt 929521 ttgatgtaat cccggctgta cagactgctg aaaatggtca ggagctgtcg ggaatcctgg 929581 ttctacttcc gccgcgaacc agccgatttt cggcttgctt ttgacatagc cctcagcagt 929641 taattgctca taagctcgtt ctatagttgc cgtgctgaca tcgagcaagc tggagagcct 929701 gcgttttgac ggaagtcttg ttccctttgt gattcgcgca tgtgaaattt cttgtttaaa 929761 aaaggtataa agctgttcat acagcggtgt tttgctcttt ttatcaagaa acggcgtaat 929821 atccatctca tgtctccttt gtagctggca tggtcatttt ttctgatatt ggctatttgg 929881 caaatgccat ttattagcta tgatcattgt aacgaaagga aaggggattg agaagatgat 929941 ccatatgaaa caattaacct cgaaagaaga atgggctgag tcgtatccga ttatgagtga 930001 attgagaaca gaactggata tagagacgta tttacaaagg cttgaagcct gtgtgcagaa 930061 agaatcgtat atgctgtttg ccttatatga aaatacagca atcagagcgc tgtgcggggc 930121 tctgccgaga gtttccattc ataaaggaga gcacttgtgg attgcggatc ttgttacaac 930181 ggcaccttgc cgatcaaagg gatacggcaa aatgcttttg gattatgcct cagactgggc 930241 gagaaaagcc ggactcggtt ttgtcagtct ttcatctggc cttcagcgta aagacgcaca 930301 tcgattttat acagataaaa tgggttttac tatagaaagt tatttgttcc gaaaaccggt 930361 ataacgaaaa aagacgcctg aaaaggcgtc ttttttaaaa gccaaactgt aaattcgtat 930421 ctacagatac aatggtatac acacaaataa tcacaaagag attaaggatg acgccgagca 930481 ggcctggacc tgtgcgccct ctcttgatga agagttcaac aacgccgaac ggaacggcag 930541 ccatggcgaa cggaagcatt tgataggaat aaaacgtgac gttgctgata atggccaaat 930601 tcagcaacag cagggacaga accgctgtcc cgacagagat ccagccgaat acattgtgtt 930661 ctttaaaaat tcttaccagt tccataattc cacctcgccg acattcgctg attttacaga 930721 tttatttttc agcatgcgct ggatttcctt ggttggccct gtaacgaccg aaccgtatac 930781 attgacaccg tttttctcta cataatctaa tcggttatct acattcaggt ctttccgttt 930841 tgaaatgacc tgagcccatt tttcgtgttt ggacatgaat ttcagggcgt tgataaactg 930901 atcgccattc gacttgcctt ttgtattaag ggcggccaag aactttgaat cctttccagg 930961 atagccaaga ggttctgtgg aagctgtctt atttgtgttt ttctctgttt cgattgcgtt 931021 ccacaaaaag ctcacatcat agcctttgaa tttgttatac acgtcttttg tcggatatgc 931081 acggtcatat gaaaggtaga cctctgatac cgttccttca ggcaatgtgc ttaacgtttt 931141 ttctgctttt gcggtcgttt gttcagactt gtttgaagga tgtgtaaagt aatggccggt 931201 tttattcact tctaagtcat agtagtttac tgccggcgct tttactttgt tataaaacat 931261 ttcaacccgt tcattcccta cggcagccgt cttcgtgcca atctgctttt gcagcgggaa 931321 ttccgtattc attccaaata gcttcacttg gcttttcagt ccggaagtat caacaagaac 931381 attcggcatg gtcagggcta cagtgactgc ggcagtttcc ataaactcat tgccggtgct 931441 gtgttttcca cccattccgt aatagaggta gcttcccagc gtacaaagcg gcaaaatcat 931501 caatgtcgaa atgacggcaa gcacagaaat tcgcaaataa gacttgcgtt tgccgtaggc 931561 taaaatcgct ttttgttttt caggactgat gctgagatcc caatcgttat cgtcctctag 931621 ttcgctgtca atcagttcct gatatacttc aagcttctcg agttcttcct caaatgcagt 931681 catttcctgg tcgctcattt ccccattttt atattgatca aaacgctttt taaattcttc 931741 attcatcatt aacacctcta ttataaagtg ctttcagccg ctgtctggca cgaaataaaa 931801 cacttttaaa attcgcctct gaaatattca taatatggga tgcttctttg tagtttaact 931861 cttttaaata atatagcgtt aaggcctccc gataattatc ggggagctcg gacatataac 931921 cagtcagcac ttcctttatc tctacctgat gggcaggact ttgaacagca ttttgaaaga 931981 ggcttccgat taagtcatca gaaatggtta cttctttctt atgctttctg acgtaatcaa 932041 tgaaggcgtt tcgcgccact tgaaaaagcc agggctttac tttgctgtga tcataggagt 932101 gaatgtgtat gtatgcccgc ataaaggttt cctgcagtaa gtcttcagca agatgcttgt 932161 cttttgtcat ggagagcagg aacctgtaaa catcattcat gtacatttgg taaatttcat 932221 cgatcgtcac tgccttttct cccctctatg ttatacacgc ataagaaagg tttaaagttg 932281 cacattacat gcaaacggct tttttatacc taatcaaaca ccattactat atagtaccca 932341 aaaatggccg caaaagatag tgcggagaaa ggtttaacat tttttccaga ggggaaaaga 932401 tagtgaaaaa gtgaaggagt ggcacaatgg aatataccag tatagcagat acaggaatag 932461 aagcctccag aatcggcctc ggcacatggg ccattggcgg aacgatgtgg ggaggcactg 932521 acgaaaaaac atcgattgaa acaatccgcg ccgctcttga tcaggggatt acactgattg 932581 acaccgcacc ggcttacggc ttcgggcagt ccgaggaaat tgtcggaaag gcaatcaaag 932641 agtacggcaa aagagaccag gtgattctcg caacgaaaac ggctctggac tggaagaaca 932701 accagctgtt ccgccatgcg aacagagcga gaattgtaga ggaagttgag aattctttga 932761 agcggcttca aacagactat attgatcttt atcaggtgca ttggcccgat ccgcttgtgc 932821 caattgaaga aacggctgaa gtcatgaagg aattatatga tgcgggaaaa atccgggcga 932881 ttggcgtcag caatttttca attgagcaaa tggatacatt tcgcgccgtc gcacctctcc 932941 atacgattca gcctccatat aatctgtttg aaagagagat ggaagagagt gtccttcctt 933001 atgcgaaaga taacaagata acaacattat tatacggcag tttatgcaga gggctgttaa 933061 caggcaaaat gactgaagaa tatacatttg agggcgatga tctgcgtaat cacgatccaa 933121 aattccagaa gccccgcttt aaagagtatc tttctgctgt gaatcaattg gataagctgg 933181 cgaagacacg ttatggaaaa tcagtgattc acttggctgt cagatggatc ttagatcagc 933241 cgggagcgga tatcgctctt tggggagcaa gaaagcctgg gcagcttgag gccctatctg 933301 agattacagg ctggacgctg aacagtgaag atcagaaaga tatcaatact atattggaaa 933361 atacgatatc agaccctgtc ggaccggagt ttatggcccc gccgaccaga gaggaaatat 933421 aacaaaagct gagggcgaat cctcagcttt ttggcgttta aacgagagaa atcttaaaaa 933481 ttagtaccag gtaataaaaa atattgttat aatagatgac agaaagaatc attgattacg 933541 acaaaggaag tgcgatatgt ataagttttg tgcaaatgct ttaaaagtta ttctttctct 933601 tcgcggagga gtgaaggtgt ataacaaaga aaaccttccg gccgattcag gttttgtcat 933661 cgcgtgtaca cattccggct gggttgatgt gattacactc ggagtcggga ttcttcctta 933721 tcaaatacac tacatggcga aaaaagagct ttttcaaaat aaatggatcg gttcgtttct 933781 gaagaaaatt catgcctttc cggtagatcg ggaaaatccc gggccaagca gtattaaaac 933841 gccgattaag ctgctgaaag aaggagagat cgtcggtatc ttcccaagcg gaacaagaac 933901 ctctgaggat gtgcctttga aaagaggtgc ggtgacgatt gcgcaaatgg ggaaagcgcc 933961 gcttgtcccc gctgcatatc agggcccttc aagcggaaaa gaattattca aaaaaggaaa 934021 aatgaagctg attatcggtg agcctcttca ccaggctgat tttgcccacc tgccttcaaa 934081 ggaaagactt gcagcaatga cagaggcttt gaatcagcgg attaaagaac tagagaataa 934141 acttgatcag ctataaggcg ttctgagaga ttgtcctgaa actgtgaaaa taagaaaagc 934201 accctataca aggtgctttt cttattatgc ttcctgctgg ttagctgtct ccagaagttc 934261 ttcttcttga agctttttca cttcaatata tgcgacgtgg tggccgtcaa tttcattaat 934321 gatgaattcg cagccctctt cgatgatgga atcatctttt tcaacatcgt atttttgagt 934381 aaggaaccag ccgccgattg tatcgacttc ttcgttctct aaatggatgc ctagcaggtc 934441 gtttacttgg tcaattaaca cttttccgtc aagaatataa tggccttcgc cgattttgcg 934501 gatttcgcta atttcatcaa tatcaaattc gtcgcggatt tcaccgacaa tttcctcaat 934561 gatgtcctca accgtcacaa gcccggcagt accgccgtat tcatcagaca aaatggccat 934621 gtggaccctc tctttttgca ttttgacaag caggtcttgg atcggcgcag attcaatgac 934681 atgaatgata gggttgacga attgagaaat ggtggaatca acagatacct caccgctgat 934741 gcaggcggtc agcacttctt taatgttaat aaccccgata atgttatctt tatcgccctc 934801 ttccacaggg tagcgggtat atttttcaat ctgaatgatg tccatcattt cagaaatctt 934861 gatatcatgc ggaaggctga caatttcggt ccgcggaatc ataatttctt tcgcgagcct 934921 gtcgtcaaat tcaaagattt tattcacata tttaaactct gattggttga tttcaccgct 934981 tttatagctt tcagacaaaa tgattcgcag ctcttcttct gagtgagcca gttcgttttc 935041 tgaaacggtc tccaggccaa atgctttggt caataaccgt gcggaattgt tcaaaagcca 935101 aatgaatggg aacgcgatgc ggtaaaacca aatcagcggt ttcgcaaaca gcatagacac 935161 tgcttccgcc ttttggatag cgactgtttt aggtgcaagt tctccgacaa caacgtgtaa 935221 gaacgtgata atggcatacg caaaaataaa cgatatgaca tgtgaaaggg aacctggaac 935281 gttcatttgg acgaaaagcg ggtgaagcag cctttcgatc gttgattcac ctaaaacccc 935341 taatccgatg gaagtcaatg taattccgag ctgacacgca gataaatatt catcaagatg 935401 cgtggtcact ttttttacgg ctattgctgc tttatttcct tccgcgatca gctgatcgat 935461 ccgtgagcct ctgattctga taatggcaaa ctcagatgcc acgaaaaatg ccgtcagggc 935521 gattaaaaca gcaactaaaa tcaaattcac tatgtccaat tagaaccttc actctagcaa 935581 tgagaatgaa ggtaacacct cctgttagat aaaatggttt taacttaaca gcagcataaa 935641 tgattggaac acggcgagct tttcaggcgg gagtttgctt ttcagcttgt cacgatcctc 935701 gggcttcagc cgttcaaacc gatgcaagat tccggagatg ttttgattca tatgatcaat 935761 ttctaatgcc agatttccaa tttcatcatc aagtttagct gaagagggaa actggttctc 935821 cagtcgatct ttaatatcgg acagggccaa tcgctgcttc ttgcaatcta caataaatat 935881 aagtcgtttg agtgcatttt cgtcgtagta acggtaattt gaacaggatc tggccggcgt 935941 aagcagaccg agattcgtat aataatcaac tgtccgtttc gttactccgg cgagtgccgc 936001 tagttcactg atgcgataag tctcagcccc atctatatcc ctcccaacca tcacgttata 936061 gttatgagaa tagtttaata tatgaacggt gtcttgcaca agtttattgt tttttttaga 936121 ccggaattgg aagttgtgga attcatcatc tgattgaagt aacataggaa gatagaattt 936181 tcaaattttt atatgcggaa gggacagatg aaattggctg ggttatcccg ggaagttgaa 936241 gaaaacttaa ataaaggatc atggattcgc aagctgtttg atgaaggtgc aaggctgaag 936301 aaggagttcg gggaagacca ggtatttgat ttttcactcg gcaacccgat tgttgaaccg 936361 cctgaagctt ttaagagagc gttaatagag gaagctgaaa aaggcagcca cggatacata 936421 caaaaccaag ggcttcttgc agcgagagaa aaagtcgcgc aatttctggg ctcgcgtttt 936481 gaagctgatt tctcagcgga gcgcatcgtc atgacggtgg gcgcgggagg cgctttgaat 936541 gttgcgttaa aaagcatcgt aaaccctggg gaagaggtca ttattcttgc accttatttt 936601 gccgaatata agttgtatat tgagaactac gggggaaaag ccgtcagctg cccgttgaca 936661 agccggtttg agatcgacat tgaagcggta aggcaatcga tcactccaca gacgaaaggg 936721 ctgattctca atacaccgca taaccccaca ggcactgttc tcagccagaa aaatatagac 936781 gatttaggcg ctttattaaa agaaatagaa gagaagagcg gccagacgat ttatgtgctg 936841 tttgatgaac cgtacagtca attaatctat gatgaagagc tggcaaatcc gtttcaatcg 936901 taccatcgtg tgatattggc cagctcattc agtaaagatc tcggcatagc cggagagcgg 936961 ctcgggtata tcggattgga cagccgaatg ccggatgcgg accttttgat caacgctttt 937021 gtgtattgta atcgaacgct tggatttgtg aatgcccctg tcatgatgca gcgggctgtg 937081 gcacgaatgg atgatttaag agtagacgcg agcgcttata aagagcgccg ggatttaatg 937141 gtagacattt taaaagaagc cggttttgaa tttgaaatgc caaagggagg tttctttgtt 937201 tttccgaaat cgccgattga agatgaagtt gcattttgcg tgcatgccgc ccaaaaatac 937261 aaattattaa ttgtgccgag cagcggtttt ggaatgagcg ggcatttccg attatccttc 937321 agtgtgccga tcgagcagat taaaaactca cgggacattt tcatttcttt atataaagat 937381 tttgcttaag aaggcaaaga aaagaaaaca gttttcaagg ctgttttctt tttatatccg 937441 caaaatcctt cctcttccaa tccagacagg cgcagaattg acaagcaggc atgcagttaa 937501 ggctttcttc atgataaaag tctaaaaatt aaaaatcatt tttggaatga gttgtgttac 937561 aataaaatat acaatttata atcaaacttt gacttttgga ggtggtatga tggggccctc 937621 tgcttaggca acaatacacc gcgtacctca atgttaagga aaaatgatta tatcaggagg 937681 tgactcctta tcctttgttg agaggatagg gttaaatgga cgatattgac agtctgattt 937741 taattggcgt gctcattgct ttaaccgcgt ttttcgttgc aagcgagttt gcgattgtta 937801 gagtgaggag atccagaata gatcagctta tcacagaagg aaacaaacgg gcgatactcg 937861 caaggcgtgt cattacagat ttggatgaat atttatccgc atcccagcta ggcattacat 937921 tgacatcaat cgggcttggc gtactgggtg agccggcctt tgaacggctg ctgcatccac 937981 tgtttgaacc gctcggcttg ccggactcgg tttcacatgc agtctctttt gcagtcgcgt 938041 acggcttgat cacgttcctg cacgttgttg taggtgaact ggccccgaaa acggtcgcga 938101 ttcaaaaggc agaacagctg actttactga tagcgggccc tttgcgttta ttctatttgc 938161 tcctgtttcc gtttatttgg atcctcaatg gatcggcgcg gcttttatgc gggatgttcg 938221 gtttgaagcc tgcgtcagaa catgatggtt cccattctga ggaagaactc aggatgctgt 938281 tatctgagag tttaaaaaac ggagagatta atccgtctga atataaatat gtgaataaga 938341 tttttgaatt tgataatcgg atcgccaaag aaattatgat accgcggaag gaaatggctg 938401 ctgtgtcaac tgagatgacg atggccgaga tgcttgaagt catgctgaag gaaaaataca 938461 cgcgctggcc agtcacagat ggagacaaag acagtgtgct cggtttggtc aatacgaagc 938521 atttgttttc tgatttgctg tttatgacag aagaagaacg aatgaagatg acgatccatc 938581 cgtatgtgag gccggtcatc gaagtgattg aaacgatccc ggttcatgac ttgctgatta 938641 aaatgcagcg cgagcgcatt catatggcta tattgtcgga tgaatacgga ggaacctcgg 938701 gacttgtgac gacagaggat attcttgagg aaattgtcgg agagatccga gatgaatttg 938761 atgaagatga acagccgctg atccaaaagc ttggcgacgg ccattatgtg atggatggaa 938821 aggttcggat cgatcaggtg aacagccttc ttggcgcatc gattcaagaa gacgtcgata 938881 cgatcggcgg gctgatatta aaagaaaaca tcgatattga ggctggtgaa tccattcgca 938941 tcggttcata tacgataaag gtgctgaaga tggacggccg attaatcaag caaatcgata 939001 taaaagaaga agccggcaac acaaccggga ttacggcgca ccacaagctg ccgctgcccg 939061 agcctgtgat gctgaacagt gcaaccttga gcgagaaata agctcaaggt ttttttatat 939121 tgtgattgtc cagccgcacc aaaatgcaaa aagcgacccg caaagtgtca ggacgatgta 939181 caagatgctt tcttttacac gtttggccat aaggagttga atagtttcaa cgctgaatgt 939241 ggaaaaggtc gtaaaggcgc caaaaaaccc cgtgccaatg ataagcgaga ccgaagcatt 939301 tgcaacgtga agtcctgtaa atattccgag cccgagagct ccgagaatat tgactgtcag 939361 tatgccaatg ggcaggctga gacctttggt tttggcggtt atgacattgc caagccagaa 939421 gcgaagcatt gcgccaagtc cgccccctat gaaaataccc gctagtgtca tttttcctgc 939481 agcccctttc tttgctgaat gcctgctatg cgccgtccca caaaaacacc aatcagtgca 939541 aatatgatcc ctgatatcaa tgaggctgcc acatataaaa gagccaatga gggttgtcct 939601 tgcaaaagca tcactgtttc cttagaaaac gtggacattg ttgtgaagcc tccgcaaaag 939661 ccggtgccta aaaaagccga cagcagaggc cgttttgccc cgatcataaa aaatccggtc 939721 aaaatgccta atagaaggct gcctgccgca ttttccagcc aggttgccgc cgggaactga 939781 ccggtgtgta tccataagtt taatccgtat cggaggcagg cgccaagcgc gcctccgata 939841 aaaaccgcgc tatatatttt catgtttgcc atcctttatg atgaaatccg ggtaatctgt 939901 aacgatgccg tccacgccca tggcttgtaa ttttgccgct gtcttttgat tgttgacagt 939961 ccatgcaaat atgtttaagc catttttatt gatggagccg atcatcagac ggttaagccg 940021 tgtgtgtttt atattgacat agtttgcaaa agagcggaag gccttcatct gatttctgga 940081 cagcatgcca aagttgggcc ttgtaatgac cgctgtcgga atcgaaggat aaagctcgcg 940141 gaacctttgg acggagcgga actgaaagga ttgaacaata ttattgatag aaaaagaaaa 940201 ttgccctaat agctgtccca cctcttcttc aattccgact tgagacggat ggccttttag 940261 ttcaattaaa aggccgattt ttttgtggta gcgcttgagc accgcttcca gggttggaat 940321 acgctctcct tgaaaagcgg gaccgtacca gcttcctgca tcgagttttt gcaattcctc 940381 caaggtaaaa tccttaacaa agcccgatcc gtttgttgtt cggtcaaccc tgtcatcgtg 940441 tatcacaaca atctgcctgt cttttgtaag ctggacatcc agttcgatca tatctgcatt 940501 cattttcacc gcaaggtcaa atgcggcaat cgtattttcc ggagcgtagc cggatgctcc 940561 gcgatgggca atgatgtaca agctaagtca gctcctcgta tgggcatttc tgttattgta 940621 tcaaatccat atatgcaccg cgatacaaac tggtgaattt tttctgccat atcggaatgg 940681 tccgggctga ggaatgcgta taactaaaaa aagacactca gcgtatcaga acacatttcg 940741 tcagaaaatt aggtctttcg acatgttcac aacaaaatat gatcctttat aatagcaaaa 940801 aaggaggcga gatcatggga aaagggagaa tcagagtgga ggaaagaatt aaagccgaaa 940861 cggatgctga aatgcaaaaa gcaactctcc ttgatcagac acaaacgaaa aaaggtaagt 940921 gactgtccct attgaatctg gctgatagat gaattgagaa atgaccccgg cgtttcgccg 940981 gggttttgtg ctgcataaga catttaaatg aacatcctta cgaatatttt agtataataa 941041 acaattgatt gggatagagg ggagacagtc atgccggatt atctgcagca gtattttacg 941101 cttgataaca tcatacaaat cggcatcagc ttggcgattt tgctggtgtt tcttatactt 941161 agaaaattat tcacaagata tttttttaac ctgcttttta atttgacaaa ccggccgaaa 941221 acagaaattt ttaaacaggt ggttctggcg tttgataagc cggccagatg gttttttgtt 941281 gcccttgggc tgtttttagc gatccggtat tcaccgtttt tagatgagca aatgccggtc 941341 atcagcaaaa tataccgctc actgattgtg gcgctcttgt gttggggtct ttgtaatttg 941401 accgcaacat cgtcgtttat cttccataag gtgaaccagc gcttcgagct tgacatggat 941461 gacattctgg ccccgttttt atccaaattg ctccgttttg tgatcattgc gctcagtgtc 941521 agtgtgatcg ctcaggaatt caattatgat gtcaacggat ttgtagcggg ccttggtctt 941581 ggcggactgg cttttgcgct tgccgcgaag gataccatca gcaacttctt cggcggtatt 941641 atcattatta ctgaaaagcc gtttacaatt ggtgactggg tggagacgtc gacagtaaca 941701 ggatcagtcg aggatattac ctttaggagc acgagattca gaacagcaca gggggcgctt 941761 gtaacggtgc cgaactctac gctgtcgatg gaagcgatca cgaactggac aagaatgacc 941821 aaacgccaga ttacgttttc catccatgtg tcctacgcta cgccgattga gaaccttgaa 941881 cgctccattc attctctcag aacaatgctc ttagagcatg agggcgttga taatgaaata 941941 atcatggtca actttgatac gtttgccgac agctactaca atttattttt taacttctat 942001 acaaaaacga cggtttgggc tgaaaacctt aatattagag aggatatcaa ctataaaatt 942061 attgagattt taggtgcaga aggcgttcag tttgcatatc ccggccaaat ggttgttgtc 942121 aagcaaaagc acgaaagcga ccaattccag gtgaatctaa ataaagagga aaaggaacgg 942181 gcttaaaaga gagacttcgt ctgacagagg cggagtcttt ttcatggtaa aataagagaa 942241 aaaggcggtg ttgagttgga aacattcaaa agtattctac atgaagcaca gagaattgtt 942301 gtgctgaccg gagcgggaat gagcacagaa tcagggatcc ccgactttcg ttcagcaggg 942361 ggcatttgga cggaggatgc ctcaagaatg gaagcgatga gccttgatta ttttttaagt 942421 tatccgcgtc tgttttggcc caaattcaaa gaattgttcc agatgaaaat gagcggcagc 942481 tttgaaccga atgaaggcca tttgctttta gctgagctgg agaagcaagg gaagcaggtc 942541 gatattttca cgcaaaacat tgacggtctt cataaaaaag cggggagcag gcatgtgtac 942601 gaactgcatg gttctatcca gacagcagct tgtccggcat gcggcgcccg atatgatctt 942661 ccccatttgc tggagcggga ggtgccggag tgcacggcgg ccggaaacaa tggggacatt 942721 tgcggaacgg tattaaaaac cgatgttgtt ctctttggcg atgccgtcat gcactttgac 942781 accctttatg aaaagctgga tcaagcagat cttttattgg ttatcggcac gtctctcgaa 942841 gtggctccgg ctagatttgt gcctgaggat gcaagcctga ttcccggcat gaagaaagtc 942901 atcataaacc ttgaaccaac gtattgcgac agcttgtttg acatggtcat ccatcaaaaa 942961 atcggcgagt ttgcccgaag tttgggcatg aaaaagtgag ccgctttatg cgcctcactt 943021 ttttattcat gaacaggaac cattgtgtcc tctaacactc cgaaggaata gcctttttct 943081 tttaatttat tgattagtac cggcagcgca tttacagtag caggaagatc atgcatgaga 943141 attacatttg ggcggcttga agagctgtgt tccatattct caagctgctg taatacggcg 943201 gtcacatact gtgaattccg gtatttccag tccatgctgt cgatcgtcca atcccagtac 943261 acaaacccat ctttctccag attgcgaatt tgtgaggcgg ttagtgacgg cttgcttccg 943321 tatggcgttc tgacaagatc ggttttatat cctgtaatgt cctgcagcgt gtcacgcgcc 943381 tcctgcattt cttttagcgg agatgtcggt gtttgataga acaatctgtt attgtgggta 943441 acgccatgta aaccgagtgc gtggccttcc ttttctgctc ttttcacagc ctgcttgaat 943501 tcgttcatcc gcggtgacag cataaaaaac gtcgctttta catcagcgct tttcagtacg 943561 tcgagcaagc gggttgtaac ggctgaaggg ccgtcgtcga aggttaagta aaccgtttta 943621 tctcccatgt tctgctttgt ctgcagatgt tttatcagga gatcggggga gtcgtttttc 943681 agcttaaggc tttccttctc atctcgaagc tggccgtttg ttgtgacagt gacttccttt 943741 gctttcgttg aactgttgga ataacccaaa atcaccataa gcaaaagcag cacacataaa 943801 actgctaaac ttgcaaattt aaaagcaagc gaaactgcag aaggagaagc ctctcctctc 943861 gtttgtcgca taacaatctc tccattggca taaaatctct acataatgct gtacagcagg 943921 cagcttatga agatgcctta tgtttacaac ctatgtatta ccagtcaagt atacaggaat 943981 aaaactggaa agcacataga aaatttgtcg aaatgtcaga ttttaaggaa aaaataaact 944041 cctttccgct atagatctct tgatctttct gtttttcagc ttgtccaata tggtagaatt 944101 agtgataatg acagcttgaa tgacatcagg gacatctcga aaagggaggg cttttatgaa 944161 ggttttagtc aatggccggc tgattgggcg cagtgaagca tcaatcgatt tggaagatcg 944221 cggttatcag tttggtgacg gcatctatga agtgatcagg gtgtacaaag gagtattgtt 944281 cggcttacgt gagcatgcag agcgtttttt cagaagtgct gctgaaatcg gaatttcact 944341 gccattcagt atagaagatc tcgagtggga cctgcaaaag cttgtacagg aaaatgcggt 944401 cagtgaggga gcggtataca ttcagacaac aagaggtgtg gccccgcgaa aacaccagta 944461 tgaagccggc ctcgagccgc agactactgc ctatacgttt acggtgaaaa aaccggagca 944521 agagcaggca tacggagtgg cggccattac agatgaggat cttcgctggt taagatgtga 944581 tatcaaaagt ctgaatttac tgtataatgt catgacgaag caaagggcct atgaagccgg 944641 agcatttgaa gccattttac ttagggacgg cgttgttacg gagggtacat cctctaacgt 944701 ttatgccgtt atcaacggca cagtgcgaac acatccggct aatcggctca ttctcaatgg 944761 aattacacgg atgaatattt taggactgat tgagaagaat gggatcaaac tggatgagac 944821 tcctgtcagt gaagaagagt tgaaacaggc ggaagagatc tttatttcgt caacgacggc 944881 agaaattatt ccggtcgtga cgctcgatgg acaatcgatc ggaagcggga aacccggacc 944941 ggtgaccaaa cagcttcagg ctgcttttca agaaagcatt caacaggctg ctagcatttc 945001 ataaatgaac gaagaaaaga gcccgctttt tacagcgggg ctctttttat tttttaacaa 945061 atccaatcaa aatggagatc attggcgata tatagaggaa gaacgtaaat gggatgtagt 945121 ctatgactgg aacaccaagt gcgctcgcca taaatgcgcc gctgacgccc caaggaatca 945181 atgggttaat taatgttccg ccgtcctcta atgatcttgt cagaaatttt cgctggatgt 945241 ttcgtttgtc atataaagat ttaaatgatt gtcccggtat taatatcgat aaatactgtt 945301 cgcccgttgc caagttgacg ccgatgcttg agcagacagt tgctgcaaca agacggcctt 945361 ttgagcggat gcctttcatg acgccttcca atagtgcaga aatcaatccg attttctcca 945421 tcaatccgcc gagtgcaaaa gcaatcataa tgagagagac agagcccatc atggattgca 945481 gtccgcctct gttaataatt ttagcggctg cctcattgtc agtttcgaaa gttgtgccat 945541 tttgtaaagc tgtcataaac gcctgcaggc tgctgtaggg tacaaaaata gcagtcaaaa 945601 ttcccgagga aataattccg gcagtcagaa cggggattac tgatacccgt ttcattgcca 945661 gcaaaacgac taagagcgga gaaagaaggg cccacggtgt cacgtttgca gcatctttta 945721 ttccggttat gacctgctga atattatcgg ttgaagcagc gtccgctgac actgatgaac 945781 cgagaaagta aaacagaacg acagtgatga gcaaagctgg aatggttgtg cccatcatat 945841 ggcgaatgtg ttcaaagatt ggtatttcgc ctattccggc tgcaaagttg gttgtgtccg 945901 acatcggcga cattttatcc ccaaaacaag cgccgcatat gactgcgcct gctgtccatt 945961 caagcggaac gccagccgcg ctcgccacgc cgatcagcgc tactccgatt gtgcttacag 946021 ttgtcagact tgagccaaca agtgtgctga tgatcataca tgaaaacaaa gcagtcaaca 946081 gaaggtggct tggttcaata aaggataggg cataaactgt catagtcggt attgcgccgc 946141 tgtacatcca ggcgccgatt aagatgccga tcagcgctag aacaataatc ggctgtacgc 946201 cgtttttgat cccgtctaca atcccttttt caatgctctt ccagggaaat ccaaaccata 946261 aagctgctgc tgaaagcatg acaacactta aaaacagcgg gatatgaggt tctacatgaa 946321 gcaagaataa gcaagaaata ataatgcaca acatgaatat aaataaaccg acggctaacg 946381 gaaacgtcag ctttttttga gaatccaaaa taacacccca tatttatctt taatgctttt 946441 gtgcttttgg gcacgaaagc attataacag aaaaaaacga aaatctatgt tttttcacaa 946501 ttatgaatat aaaagaagtg agcacagggc gtgctcactt tacaatcagg acgggtatat 946561 ccgatttcgc tgaaagcttt tcacttacac ttccgaatat tagctttttc agcctgtttt 946621 ggtctctgct tccggttacg atcatatcgg cagaaatgcg gtttgcatgc tcgataattg 946681 attcagccgg atcgccttct aatatatcga tatctccatc tgcctgctgt tcattcagca 946741 tcattctggc ttcggcgatg acttcttccg tacggtcttc atagatcatt ggctcaggtg 946801 atgttacatc cgatatcagc ggatcaggaa cacttgtcat gcctccgctg atatagcttg 946861 cctcagctgc gggtctgggc gggtcgatga cggtctgatt gtctttcata tcatgtgaat 946921 gggcgacggt aatagcggca tttacggttt tagcaagatc aatggctgtc agaagcgctt 946981 tcttactatt ttcacttccg tcaaacgcaa caatgatacg gtcagcatgg aacatccttc 947041 tcaccctttc aaagcgtctt acaacactac tacccgaatt tgagcacaat taaccttttc 947101 ctattcaagt aatgattgac aataaaaggt tttgtttata tgatgataaa aagatgaaat 947161 cagaatggaa ggagggtttg ctatgccaag gaatttgcgt gtttatcaaa cagtttcata 947221 ttggcgcggc aaaccttttg ttctgttttc gtgaacggtt ttttaggtcg gaccgcgcgc 947281 tgaaaagcgc tgtgcgtaac atatcggtta aaaaaggcat ggagctgacg cttcatgcct 947341 tttttatata caaaatctaa ggaaagacag gtgtatggga tgtgaagaca aatacagagg 947401 cgagggcagt tcgtgccaaa ctggatgaaa aaagctgcaa ggaaaaaata gaaggcggct 947461 gatgaggaga tggggataga tgttttcagt tttgaaaaag cttggctggt tttttaaggc 947521 gtactggctg cgctatacga ttgcgattgt ccttttatta gcagtcaatg tcattgaaat 947581 gtttccgcct aagctcttgg ggaacgccat agatgatatg aaagcagggg catttactgc 947641 ggaagggctg ctgttttata tcggtatctt ttttgtgctg acggcggccg tgtatatcat 947701 gtcttatttt tggatgcatc agctgtttgg cggagcgaat ctgatggaga aaattcttcg 947761 tacgaagctg atggggcatt tgctgactat gtcgccgccg ttttatgaaa aaaaccgaac 947821 aggcgattta atggcacgag ggacaaatga tcttcaggcc gtcagtttaa ccacagggtt 947881 tggcatcttg acgttagttg attctacgat gtttatgatg acgatctttt tgacaatggg 947941 gtttttgatc agctggaagc tgacctttgc cgccattatc ccgcttccag tcatggcgat 948001 tgcaatcagt ctatatggaa gtaaaattca tgagcggttt actgaggccc aaaacgcgtt 948061 cggggcgctg aatgacagag tgctggaatc tgtttcaggc gtgcgggtga ttcgcgcgta 948121 tgttcaggaa acaaacgatg ttcgccggtt taatgaaatg accgctgatg tttatcagaa 948181 aaatatgaaa gtggctttta ttgattcact gtttgagccg acggtaaaac tgcttgtcgg 948241 cgcaagctat ctgattgggc tcggctacgg agcgtttctt gtattccgga acgagctgac 948301 gcttggagag ttagtgtcct ttaacgttta tctcggcatg atgatttggc cgatgtttgc 948361 aatcggtgaa ctcattaatg tgatgcagcg cggcaatgcg tcattagatc gggtaaatga 948421 aactctttct tatgaaacgg atgtgacaga tccaaaacag cccgctgatc ttaaagagcc 948481 tggagatatc gttttcagtc atgtcagctt tacatatcca agctcaacaa gtgacaatct 948541 tcaggatatt tcatttacgg tgcgaaaagg gcagactgtc gggattgcag gtaaaaccgg 948601 gagcggaaaa acgacaatta ttaagcagct tttgcgccag tatcctccag gtgaagggag 948661 cattacattt tcaggtgtac cgattcagca aatccctctt gaccgtctcc gcggatggat 948721 cggatatgtg cctcaggatc atttactgtt ttcacggact gtaaaagaaa atattttata 948781 cggaaaacag gatgcaactg ataaagaggt tcagcaagcc attgccgaag cacattttga 948841 aaaagatttg cacatgcttc cgtccggtct ggagacaatg gtcggtgaaa aaggcgtggc 948901 actgtcaggc gggcagaaac aaagaatttc gatcgcgaga gcactcatgg cgaatccgga 948961 aatcttgatt ctggatgatt cactttccgc tgtagatgcc aaaacagagg ctgcaattat 949021 caagaacatc agagaaaacc gcaaaggaaa aacgacattt attttgacac accgattatc 949081 cgcggtagag cacgctgacc tgatccttgt gatggacggc ggcgtcattg ctgagagagg 949141 cacgcatcaa gaactgctgg ccaataatgg gtggtaccgg gaacaatatg aaagacagca 949201 gctgttcact gcggaagaag ggggagcagg ggcatgaaaa taggaaaaac gttatggaga 949261 tacgcacttc tttatcgaaa attgctgatc acagccgtcc ttttgctaac tgttgccgtc 949321 ggtgcagaac tgactgggcc ctttattggc aaaaaaatga tagacgacca tatcctcggc 949381 attgagaaaa catggtatga agctgcggaa aaagataaaa atgccgttca gtttcacggc 949441 gtctcatatg tcagagagga ccgattgcag gagcctgttt caaaagcaaa agaagcgcat 949501 atttatcaag tgggaatggc gttctatttt gttgatcagg ctgtcagctt cgacgggaat 949561 agaacggttt ctgacgggaa gctgacgatc acaaacggag acaagagccg ggcatatgct 949621 gccgaaaagc tgactaagca ggaacttttc cagttctatc agccggaaat aaagggaatg 949681 gtgttactga tctgcctgta tgggggcttg cttgtgtttt cggtattctt tcaatacgga 949741 cagcattatc tgctgcagat gagcgccaat cggattattc aaaagatgag gcaggacgtg 949801 ttttcgcaca tacagaaaat gccgattcgc tattttgaca accttccggc cggaaaagtc 949861 gttgcgcgga ttaccaatga tacggaggct attagggatt tatatgtcac agtgctttca 949921 acatttgtga caagcggaat ctatatgttc gggatattca cggctttgtt tctgcttgat 949981 gtgaagcttg cgtttgtatg tctggcaatt gtgccgatta tctggctgtg gtcggtcata 950041 taccggagat atgcgtcata ttacaaccaa aaaatccgct cgatcaacag tgacattaac 950101 gcaaaaatga atgagtcaat tcaaggcatg accattattc aggctttccg ccatcaaaag 950161 gaaacaatga gagaatttga ggaattaaat gaatcacatt tttatttcca aaacaggatg 950221 ctgaatttaa actccttaat gtcccataat ctggtcaatg tcatccgcaa tcttgcgttc 950281 gtctgtctga tctggcattt tggcggtgcg agcctgaatg cggcggggat tgtttctatc 950341 ggtgtgctgt acgcgtttgt cgattatttg aaccggttat ttcagccgat cacaggcatc 950401 gtcaatcagt tttcaaagct ggagcttgca agggtctccg ccgggcgtgt ttttgaactg 950461 cttgaagaaa agaatacgga agaagcgggt gaaccggcga aggagcgcgc gctggggcgg 950521 gttgaatttc gtgatgtgtc atttgcgtat caagaaggtg aagaggtatt aaagcatatt 950581 tcctttactg cgcaaaaagg cgaaaccgta gcgctcgtcg gccataccgg atcaggaaaa 950641 agctcgattt tgaatcttct gtttcgtttt tatgatgcgc aaaaaggtga tgtcttaatt 950701 gatggaaaaa gcatttacaa catgtcaaga caggaactca gatcccatat gggtattgtg 950761 cttcaggacc cgtacttatt ctcgggcaca atcggatcta acgtaagtct ggatgacgaa 950821 agaatgactg aagaagaaat aaaaaatgca ctgcggcaag tcggtgctga gcctcttctt 950881 aagaagcttc cgaagggcat taatgagccc gtgattgaaa aaggcagcac gctatcctct 950941 ggagagcggc agttaatttc tttcgctaga gctttggcgt ttgatcccgc gatcttgatt 951001 ttagatgagg caacggcgca tattgataca gagacagagg ccgtgatcca gaaggcgctt 951061 gatgtcgtca aacaaggacg caccaccttc gtcatcgctc accggctttc aacaatcaga 951121 aatgctgatc agattttggt tcttgataaa ggagaaattg ttgagagagg gaaccacgag 951181 gaactgatgg cattagaagg ccaatattat caaatgtatg aactgcaaaa gggacagaaa 951241 cattccattg cataacgctc aaaaacccaa aacaatcgtg ttttgggttt ttggtttatg 951301 tagtcaataa gccagtccga cacggtttcc gacatactca cctgtaacga gctcacgata 951361 taaaaagtcc gcagtatcgc cgaccgaaat gcttgtgccg ccctcaggca aaacgttacg 951421 ctccgtacga taaacgccgg ttgctgttcc gtccgggagg taagtggggc agatgattgt 951481 ccagtctaat gatgattctt taagcatttc gtatactttt gcatgctcct tggctgcgcg 951541 ggtctgcttt cgtttcgatt catttgtttc aaaccggtat tttcccggtt catatcggga 951601 atctaggatc cctgcggtgc cgatcgtaat aagccgtttg atatgctgtt cctccataac 951661 ggagagaatg tgtgccatag cagttgacaa ggtatcatca ccatctgtgc ctagacagct 951721 gatcacgatt tcagcattct ccattatttt tttcacatct tctaagcggc gggcgttccc 951781 catgacagtt ctgtcttttg aaaggggaag atcagcatgt tgagatctga tcagagcgaa 951841 aatatcaaat ctttcatctg ctgcagcttg tgttaaaaag gcttgtccga cgcggccgct 951901 ggctcctaat aaagcgattt tcattaaaaa acctcctcgc ctttcattat aaaaggatgt 951961 tctcagtttg aacagcgcgg gaaagaatac ctgtacaaat aaacagaacg atgggaaaca 952021 tattcatgaa tcatggatac acttacgaat tgaaccagct cccaattcac aatggtgatg 952081 aatgacaccc cgattccctc cctttttttc taggatatgt ggagcaggaa aaaagggtga 952141 caaaataaag agagcgcgga aaccgcgccc tctatagcca tatattgaat tgttattgaa 952201 ctctgccgcc catttgctgc tgagcgaaag atactaaacg ttttgtgatt tctcctccga 952261 cagaaccgtt agcgcgagaa gttgtgtccg ctccaaggtt aacgccgaat tcagaagcga 952321 tttcaagttt catttgatcg atagcctgag ctgcgccagg aactagtaag tcatttgaag 952381 agttttggtt agccatgtgt aaaatctcct ttttatttag tatggttggg ttaactggag 952441 ttgcaccaat ctgtgaaccc ttctcgggtg tcactgccgc ctcggcgtaa cccaatgctt 952501 tgccggcttg ttactacgta ttatgttaaa atggccggaa aatcatgcgg agaattgtgt 952561 ggtaaatctt gagaaataaa aaaagcttag ccgtttaggc taagctagtc ataaatatga 952621 aaaagcatca gttcatgtat ctcgtttgta agagcaggct cgtcagcgcg ggcgggaaac 952681 aagtctcccc attcaatctc accgctctta tgatagatgc cttcataatg ggtcccttta 952741 taataaaatg aaattttcca tccgggcagc ttttcttttg ggaacaaagg tttccagctg 952801 aaatgagaaa tcattacggc cacgctcctt acatttggta tcaattgacc taaataaaaa 952861 cggcttatgt tcattgtatc attgtttcag aacatcattg aagaggccta aatatgcagt 952921 ttgtcccagc tttggataaa gataagcccg ctttattaaa aaagcggaca ggttacgaag 952981 gccacaatgc ttccggagat gtgattgcct tctcagataa atatgacgcg tattcaaaac 953041 ttcttcgttt tgtaagagaa tcaacatgat gcaaatttgg atgagaaaaa atgcttcggc 953101 ccgggcgcga attcgcttca aacatccata ctttaccgtt ctgatcaatg ccaaaatcga 953161 aaccaatctc cccgataaat ccctcgatat gatcatgaag gacatggctt gcagtcagtg 953221 ccgctgcaga aagcttttta atgacctcaa ctctttcagc gggatcatcg tatacttccg 953281 caagtgtctt tacagtgccg ccgttagaaa gatgtgttgt aatgctgttc tttccggaaa 953341 tttttacggc gattgctgtc actgtccatt ttccttttct gtttttattg gtatggacac 953401 ggaaatccgc tggtttgcct tgaaattcga tgagatcaac accttgctga atgagaaagt 953461 cggacgggtt gtgatgtttt tgaaattctg caaggaatga ggcggcatcg gaataatcaa 953521 ttgatgtaaa agttttggcg tcattcgtat gctttaccgt caggccgcca tctgttcttg 953581 tcagctgata aatgccggtg ccgagtgctc catttgccgg tttgatatag acttttttgt 953641 atgcgccaca gagctcatct atcagctcca cagacggtgt cagctcggat ctaggcaaaa 953701 agggtgccgt tcttggatct ttttcgagca attgatgaac gttccattta ttgaaaaacg 953761 ttttattaaa ccatgggatc tgatattcat cgatcagcct cttttttgta tgttgcaaga 953821 gaagtgaatc ttcaattttt cggttcggca aacggtcata aacgacgttc ggcaatggaa 953881 cgattttttt ctcccagccg ttttccctgt aaaggaggcc ttcaatcgtg ccttcctccc 953941 aattgatttg gtgcgcgcca aaaacgaagc agtagccccc ggcttgctcg tgtaacgtga 954001 caagtttaga aaaaaagagg gaacgatcct taaatgggcg ttcaagagat acagtaaacc 954061 ctgccgtaaa gatgccgact aacggcccga tatgcactgt atgatcatga atcagtatat 954121 ctgccctgct tcggtgggga agcaaaagct catgaaacag attttcagag agaagcacgg 954181 tttgttccag atgccgtctg taagcaacgt ggcatctgac aaccttcgtt ccgaatgcgg 954241 catgcaaaag tccgtcttgc ttcagcgaag agggcagaaa cagggtgttt tcactggttt 954301 tgtctatgcc gatcaaaaac cgtttaggat tcacgcggaa gaactccttt ctggctttgc 954361 tcagaaaaca gatattggca gcgttttagg ggacaagtgt acagctgttc tttttgctcg 954421 ggagagacac gcaggattga cttcctgcct ggtttggaat tgatatctaa aatccaaatt 954481 ctcccgtcct ttgcaagaca tatatcaaga ccgagttcaa acaacggccc atagcgctcg 954541 tcaagataat acggaaccga ttgggtaatt gaaaacacat catctagtaa aaccacttgc 954601 tgttttttcg gtatatcttc aaaccaggag tcaaatgtca gcgcatcaga tccgcctgac 954661 aaattggcca gcagcccgtg tttgtatccg cgtcttactg cctttccgac tgtattccat 954721 tcacctgctt cgtttttttc cataaacaga cgaatatcac aagggtattg ttccttatct 954781 tgaatgttta agtaaggctg aagcaaatat tgatgctgaa gcactttttt gcaccatgtt 954841 ttaaaagaag tctggttgga aaacgttttt gtctgcttat cctttccgat gtgataagta 954901 gcagtgatgt ttttcttgcc cagcttcaaa agaatcacgc ctctgcctcc cgcgccgaat 954961 gccggtttaa ggatgcaggc tttttctttg gataaaaagg agtgaatttg ttcgtagcgg 955021 ctcaccttta tcgtttcggg aatataggga ttgattacag agtgctgctg caaatcgtga 955081 aggacggtcc acttatcggg aagaccccgc ccgataaatt ccgttttcgg atattttttg 955141 agccactcaa cgattggttt tgctttttgg gaatgtgaat ccttgccgta aaaacagcga 955201 tcataaatat aatctggaat cgccatttca gtttcgttcc atgtgctgct ggccgaatga 955261 tagaccgatg ctttgacacg caaagtgtca ggtgaaatat caaatggtgt aaaccggatg 955321 aaacgtatgc cgaattcggg tgctcttttg gccagttctg cggaataatc cgcttcatgc 955381 tggcgggata aggacataaa accgagtgtt atcatggtga gactccccct tttattcaaa 955441 agctgccggc gggtgtccgc agctttacac taaatacatg taagacgaac gcagctgacg 955501 gtattctact ttacagaata cgattctcca ccttgcccta ttccaaaaga acaagctgat 955561 tttctaagaa caggaatttg tctcctcgtt tgctaagtga ttgcatgagc ctctataata 955621 cgtataggta cataatctat atgaaaaaag ctgaagcaca gatggaggaa gatgaatagg 955681 aatgggtatt gcaggaacct ttatttttat gatcgtgatc ggcgctgcca ttggagcggt 955741 gaccaatcat ttagcaattc aaatgctgtt taggccgtat aaagcgtact atttgtttgg 955801 gaaacgagtt ccttttacgc ccgggctgat tccaagacgg cgagatgaac ttgcaaaaca 955861 aatgggactg atggtagtca atcatctctt aacccctgaa ggcattaaaa agcggctcgt 955921 ctctgatgca gccaaaacgc aggctcttcg agtgggggaa cagctgattc aaaagctgtc 955981 actttctgaa gtgacagtaa aagaagcgct tgaaaaagcc gggatgaagc gccccgaaaa 956041 agctgctgat gcatggatca gcagctggac cgatgataag ctgcatgagc ttttccgcca 956101 atacggggac caatcgttaa aagagctggt gcctatagag gtgcaggaaa agcttgagga 956161 aaaaattccg atgatttcag gatatatatt gtcacggagt gtccgttatt ttgaaagtga 956221 tgaaggaaaa atccgtcttg gcaatatgat tgatgacttt ttaaaagagc gcggcatgct 956281 tggaagcatg gtgcaattgt ttcttggcaa ttcaagcctt gcggatcgcg tgctgccgga 956341 gctgctgaaa ttcttgcgca atgaggaaac aaataaattg ctttctgatc tcttaaaaaa 956401 cgaatggggc aagctgaggg agtatacgtt taatgaagca gatgaaaaat ggaatgcaaa 956461 ggcgctcatt ttcagtttga aacgaagagt gctgcaagca ttttcgactg cccctttctt 956521 caacaatacg attggcacgc ttaccgtccg ctatgaatct gagctgaccc agcaaatgct 956581 gccggcacta ttagacaaat tgcttgaagg tatttcgtcc aaccttgaaa gtgtcttaaa 956641 acggttgcgt cttgaggaaa tcgtcaagga gcaggtggat cagttcccgg tggagcgtct 956701 tgaagaaatg gtgctgtcca tttcaaaaaa agaatttaaa atgattacct atttgggggg 956761 ccttctcggc ggaattatag gcgcgattca agcattgttt gtcatccttt tttaagaaga 956821 aatggttttt gattaatgaa aggagctcca tagtctgtta tagtggagtg gtatgtcaaa 956881 cggcaatgat gaaaggagct atttacaatg gctgttaatt tttatgatgt agcgtatgat 956941 ctggaaaatg cattacgcgg gagcgaagaa ttcacccgtt taaaaaacct ttacgacgaa 957001 gttaacgcag atgaatcagc gaagcgcatg ttcgaaaact tccgtgatgt acagcttaga 957061 ctccagcaaa aacaaatggc aggagaagag attacacaag aagaagtgac gcaggctcaa 957121 aaaacagttg cgcttgtaca gcagcacgaa aaaatttctc agctgatgga agcggagcag 957181 cgcatgagca tgctgattgg tgaattgaac aaaatcatta tgaagccttt agaagagctt 957241 tacggcagtg ttgaaggcta ataagcaaaa tcccttcttg gataagaagg gattttttat 957301 tcactcagca aacttggaaa tccaatgaat cttttacctc tccattgatg atgactgata 957361 atgtatgaat tcctttgtaa tgctttctgg tggttaaatc cttaaaggat tggattcttg 957421 tgtatgactt cgtttcgttt tttcgtatat ttgtttctgt tattttaaat actttctgat 957481 gacgctggcc tcttgctttt acaaaatcaa ttgcgtactc aattcttact ttttgatccc 957541 tgtctgaatg aatatagaaa gaaaattcaa ggctttcgcc aataactata cgtttgggct 957601 ggcatgttaa atcatgtagt tgtatcgaat cagcattttc ataaccaaaa agcgctaagg 957661 cctgtttatc accctttttt aataaggtcc gataggcgtg tttgataatc cagtctgtat 957721 ggggatgtgt tccgtaccat tgatctgcga cttttctcag taaatgagga tgcgtttttg 957781 atatatcatt aaggttgttg gccacgcttt ttcttacata taaagactcg tcctgcatca 957841 gcttctcaag gatcggcaat acgggggaag ggtccgattt caaagccggt atcgattttc 957901 cccatggcag gcggggcctg ctgccttcgc tcgcaagtct tctcacgtgt tcatttttat 957961 gctcagacca tgcaagcaat tgtgcaatca tcttttcttg atctaacagc aaaaaaggcc 958021 ttacagcaaa ttctgaggtc gaatattgcg taaaggattc caatgccttt attgattctt 958081 cccaatgcgc taacccgtac tgttccacat aatctggaaa taaaattccg ctgagtcctt 958141 taaaatgagg ggctgtatcc cgtaaaattg tgagcgcttc aacgtattgt tttggcaaag 958201 tttcgtataa agaaactgtc acgcggcgca tccgctcttt taaagtgagt tcaggccagt 958261 cctccagccg taatgtatcc aagaatctgt ttttgttaaa atcaggatag gatgacctta 958321 catgatggat caactgagat atcagttctt cattatatat ttcttttaaa tcagccatat 958381 aaacaccgct ttttcgttta ttatttatat tgtatgggaa tgtacgttct ggatcaagtg 958441 tatagtccta aaaattaaca actgatccta ccacggatat acaaaagttg gttacttttt 958501 ttagttaaaa aaacccttgt catcggaaag gaaaactgag ataataacat tgaaagcgcc 958561 tacacttacc tatttcaaat ggatacggtc gcatatcatg ccgttatata gaggggataa 958621 gcaacagaga gtaagtgttc ggagcgcatc attggtcaaa caaggggttc ctgatacatg 958681 atttttcgta aatcgaaata acgatattag ggagaatggc tgcttcgatc gtatcctatc 958741 aacaagccat acataaagtc tgctgagcca ggcttttttt gctttaagaa aaggttgttc 958801 taaacacaga gacagggtca tatcctatac acaagtacag tcatcaagga gggggacatc 958861 tctgtgtcaa aacaattgct tgccttaaat atagatggag cgctgcttcg gtcgaacggg 958921 aagattcatc aggcaacgaa agacgcgatt gaatatgtaa agaaaaaagg gatttacgtc 958981 acacttgtga ccaaccgtca ttttcgctca gcacagaaaa tagcgaaatc gctaaagctt 959041 gatgccaagc tgatcaccca tagcggggca tatatcgctg agaaaattga cgccccgttt 959101 tttgaaaaaa gaatttctga tgatcatacc tttaacattg ttcaagtgct ggagagctat 959161 caatgcaata ttcggcttct tcacgaaaag tattccatcg gaaacaagaa aaaggtgaat 959221 tcgaatttat tagggaaagc actcattcat ccgtctgacc cgatctttta tccagtccag 959281 ttcgttgaat cattaagcga tctcctcatg gatgagccgg tgagtgcacc cgtcatcgag 959341 gtgtacacgg agcacgacat tcagcatgac attacagaaa cgattacaaa agccttccct 959401 gcggtggacg tgattcgcgt aaacgatgag aaactgaata tcgtcccgaa gggtgtctcg 959461 aaggaagcgg gtttggccct cgtcgcttca gagctgggcc tgagtatgga tgatgtcgtg 959521 gccattgggc atcagtatga cgatctgccg atgatcgaac ttgccggtct tggggtagcg 959581 atggggaatg ccgttccgga aattaagaga aaggcagatt gggttacaag gtccaatgac 959641 gagcaaggtg tcgcttatat gatgaaggaa tatttccgaa tgcagcagcg aaaaggattt 959701 cttgataagt tccacatgaa acgtgtgtaa aaaagccgct cgcgccctga caggtgcggc 959761 ggcttttttg ccggattgat tttagcagtt tatttctgta cactaaagaa agttttgaat 959821 ctgataaatt aggtgatgaa gttgcaaatt aaaatagaag gcatacatga tgaccgcctg 959881 catcggcctc tgcaaaatat tgcaaatttg ttttatgaag agtgcgagct tgcgtatggc 959941 ggagaggagc ccgcagattt tgtcatttct ttagcgttgt cacaaacgga tgagcatgtg 960001 acggtttctg gagaagtgaa gggtactggc ataaaggaac agcatacaaa attcttttct 960061 ccagacatga ctgaaaaaga agcttttaag caagtgaaaa acacaatttc ttatgtgtat 960121 ctcaatcttc ttcaggcgca tacgggcatt acgcagaagt ggggaatcct cacaggaatc 960181 cggcccacaa agctgcttca taaaaaactg caaagcggaa tgtccaagga gcaagcgcat 960241 gctgagttga aaaaagacta tttaattcat gatgaaaaaa tcatgctaat gcaggaaatt 960301 gttgaccgtc agctggcggc agtgccggat ttgtaccgag taaaggatga agtcagcatt 960361 tatatcggca ttccgttctg cccgacaaaa tgcgcgtatt gcacattccc tgcgtacgct 960421 atccaaggac aggcgggcag agtcggctca ttcctatggg gactgcatta cgaaatgcag 960481 aaaatcggtg aatggctgaa ggagcatgat gttaaggtta caaccattta ctttggcggc 960541 gggacgccga caagcattac agcggaggag atggatctgc tgtatgaaga aatggtccgc 960601 tccttcccgg atgtgaaaaa cattcgtgag attacggtgg aggccggtcg tcctgacacg 960661 attacagaag aaaaactcgc cgttttaaac aaatatgaca ttgatcggat cagcatcaat 960721 ccgcaatcct acgaaaacga aacgctaaag gcgatcgggc ggcaccatac ggttgaagag 960781 accattgaga aatatcatct gtcacgccag cacggcatga ataatattaa catggacttg 960841 attattggtt tgcctgggga aggcgtgaag gagttcaggc acagtctttc agaaacagaa 960901 aaactgatgc cggaatccct taccgttcat actctttcat ttaaacgggc gtcagaaatg 960961 acgagaaaca agcataagta caaagttgcc ggcagggaag aggtttctca aatgatggaa 961021 gacgcggtag cctggacgaa agagcatggg tacgtgcctt attatttata ccgccagaaa 961081 aacattcttg gaaaccttga aaacgtcgga tactctttgc cgggacaaga aagcatctac 961141 aacattatga ttatggaaga ggtgcagacg attattggca tcggctgcgg cgctgctagt 961201 aaatttattg atcgggatac agggaaaatt acgcattttg cgaatccgaa agatccgaaa 961261 tcgtacaatg agcgcttcga gcactacacg gacgaaaaaa tcaaatattt agagcagatt 961321 tttgaaaaaa cgacaaagca gcactgatta cagtgctgct ttttttatcc ctgttttttt 961381 gcgggctgaa cctcaggctt ccatttaaat accttgttca gcaagcggta aattcgtttt 961441 gattcctttg tgacaagcgg tcccaaaatc gccagaatga ggacatataa tgcggcaaac 961501 ggctttaatg tggccgacag tccgccggct atcccgagat tcgcaacgat aatcgaaaat 961561 tctccccgcg atacgatcgt cagcccgata ttcgatgaag ccttatgaga aagccctgcg 961621 cgtcgtcctg ccaccattcc ggcgataaaa tttcccagaa tggtcaaaat cactgcaccc 961681 aacgcaagcc aaaccgcttc accaagcgaa aacggatcga tgctgaggcc gaagctgaaa 961741 aagaacatcg caccgaagaa gtcgcgaaac ggaacaacga ggtgttcaat cctatcggaa 961801 tgctctgttt ctgaaaagac caaaccgagc agcagcgcgc cgattgcttc tgctacatga 961861 atcgtctctg aaaaaccggc gataaaaaag agtgctgcga aaatgacgat aataaacact 961921 tcgtttgagc gaatgtccaa cagtttgttc aacagcggcg ggagttttct tgctgcgata 961981 aaaaacagca gcatataacc gaaggcgatc aaaatggaca agagtgcact ccctacggat 962041 gtcgcatcac ctagtataag gccggaaaca acggacagat atacggcaag gaaaatatct 962101 tcaaacatga tgatgccgag aatcaattcg gtttccgggt tggcggttct ttttaaatca 962161 acgagcactt ttgcgacaat cgcacttgac gagattgtga tgacgcctgc gaggatgagg 962221 acttccagaa aggaaaatcc ggtgataaac ccgtaaagca gtccgaggct gaagttaatc 962281 aaaatataaa tcgtcccgcc gaccgcgatt gattttcctg atttgattaa cttcccgaca 962341 gagaattcga gtccgagata gaagaggagg aacagtacgc ccattcgccc gaaaaactcg 962401 atgatttcac tgctttgaat aaatgttaga tcaataatcc ccattttcgg cgcgtgcggt 962461 ccaacaagca ttcccagcac aatcagaaac ggaataatcg aaaatttaat tttattggcg 962521 atcacactgg cgattgccac aagcacaagt gcagttccga cttcaaatac aagatggtcc 962581 atcggggctc acacgccctc tccagaaaga aaatcgtgaa tcagtttctt cagatgcttt 962641 ctctcacctg agaggacaag ggtgtcattt tcttcaataa tcgaatccgc tccgggattt 962701 aggagctttt cctggttgtg tttgataatc gcaataacag tgacatcgta attctggcga 962761 acatcaagct caccgagtgt gcgtccgatc gatttggcgc ctttttcgac cttaaaccat 962821 tcaataataa gatcgctgaa ggccatttcg atggactcca gagcttgcgg tttatagacc 962881 atgcccccga gaatagctgc aatttgcctt gcttcagaat catccaatga aatatttgaa 962941 agaagctcat ccgggtcccg gtcattaaac cggtaaattt cccttcttcc gtcatcatga 963001 atgataatcg tcattttttc gtggcttctt gtttcgattt caaacttttt gccgatgccc 963061 ggcagatcgt tttctttaat attcaatgaa aatccctccg aatgtagtgt tggcagtatg 963121 gggtgagtta caaataaaac ttgagcaaat tatattcgga ggtaattaga ctggtatttg 963181 acagggacgg ccaaagcctt ttccagcctg tttatcagcg gttcgtcaag tggtttgaca 963241 gagagctgcc tgacagactg cgccagcggg ctgtactctt tgatcagctc agccgggtgc 963301 atgctgcccg gcgatggcgt ttttgccgat tgtgtttcct gcggatatga agacataggc 963361 acatagctgt cagtgcttgc ttcaaactgg gaaggcagaa ccacgtccga agggggaaag 963421 tacaccataa ataaacttaa cagaaaactg atcagcaatt tatccatgtt cctttcctcc 963481 cttctcatca agatatccct tctttttcac tatataaaac tttatgtttc cattcaaaca 963541 atatgcattt ttcagtatct attgaccttg aaaaataaaa aggtttattt ggggatggcg 963601 gggaatgtat aggagaaaga aaaaagtaag cgcatacatg gaggtgcttt taatggagtt 963661 tgttcaatat gcatgtaatg gggccgttgc agagattatc ctgaatcggc ctgatgccca 963721 tcacgccctg aatgaacaga tgctgtctga attgaaggag gcagtcgaaa tggcggctgc 963781 aagcgaggcg ctcatcgttc tcctgagagg aagcgggaaa ggcttttcgg ccggcggtga 963841 tatcaggatg atgacgtcag agcatgaccc tgaccaattt aaacggctga tggatacgat 963901 tgaggctgtc accctgaatt tatatcagat gaagaaagtg acaattgcag ccattcatgg 963961 tgctgctgcg ggactgggcc tgagtttggc gctttgtgcg gacattgtgc tcgctgaaaa 964021 aaacgccgtt ctcgcgatga attttatcgg cattgggctt gttccggacg gcggaggaca 964081 ttatttgctg aagaaaagaa tcggtgaagc aaaagcgaaa aaactgattt ggagcggaaa 964141 aaaactatct gcctcggaag ctgccgatat ggggcttctt gatgggacat ttgccggaga 964201 ccctgccgaa ggcgcaagac ccattatcga aaccctgttg gcctcccctc ttttggcgat 964261 gatcgaaacg aaaggtattt ttcaaagcct ccaaattgaa gaactgaaaa aagtgctatc 964321 ccttgagcgc agcgcccaag agagaatgag aaggaccaag gatcaccaag aaggaatccg 964381 tgccttttta gaaaaacggg agccgaagtt tcaagcgtaa cagatcagcc ggaaagctga 964441 tcatctgtga aacaaaatca gctttccggc tgcattgact aaacgatgag tatgactatg 964501 aagctctttt tcttttaaga gggcttcacc atgcgttttt gccgcttctt catgttctgc 964561 ctcgaattgc tcgtttacca gcgtgttccc cgaaggatca aatacggtaa ggaaataatc 964621 agccatcagg tttctcctcc attttaaggt ttatcagtct ttcttcattt atattctaaa 964681 aaggaaatca aaatccttta ttatgcttta tccaaaatta gtatataatg ggtcagggaa 964741 ggaggagatt cagtgcttac aattgatcac gtaacgaaga catttggaga ttataaagcc 964801 gttgacggat tggacttaga tattccggaa cagcaaatgt tcggtctatt aggcgcaaac 964861 ggagcgggaa aaacaacaac gtttcgcatg atcctaggat tattaagcat tacggagggc 964921 tcaatcagct ggaagggccg tcctgtgaat tatcatatca gcaacaaaat cggttatttg 964981 ccggaagagc ggggccttta tccgaaaatg aaggtaaggg atcagctcgt ctatcttgcc 965041 agattaaaag ggatggagaa gcgagaggct gtaaaagagc tcgggacatg gcttgaacgc 965101 ttcaatatta cagattacga gaataagaag gtggaagagc tttcgaaggg gaatcagcag 965161 aaaatccaat tcatttcggc agttttgcat aagccggagc tcctgattct tgatgaacca 965221 ttcagcggct tggaccctgt caatgttgag ctgctaaaag aggccgtgat ctcgctgaaa 965281 aacagcggtg tttctatttt attttcaagc catcggatgg aacatgtgga ggagctttgt 965341 gagaaccttt gcatattgca gaaaggaaaa ccggttgtac aaggcaagct gaaggagatc 965401 aagcgttctt tcggtaaaaa gaatgttacc attcactccg atgacgatct gcgctttttg 965461 cagtcccatg aaggcattct tcaatggaag gaaacggcag acggcgtcaa gctgcagatt 965521 gccaatgaag acatttctca agagattttt gcgatgctcc aaggaaaagg gtttatcaga 965581 aagtttgagc ttgaagagcc gtcactgcat gatattttta tagaaaaggt gggggccgtc 965641 tatgaataaa ttttggatca tgctttctca tacatacaaa aataagatta tggcaaaatc 965701 ctttattatt tcgactgtca tcacggtgct gcttgtttta gttgtaacga atctggagtc 965761 gatcatttct ttgtttcaag gtgacgatgc gaaagaaaaa atcgccgttg ttgatgaaac 965821 aaacgaatta tatccggttt tttctaagca gctgaaagcg gtggatacag acggcgatct 965881 tgatgtgaag ctgtcgaagc aatcggagga tgaggtcaca aagcaagtca aagatgaatc 965941 actcgatggc atgctcatca tcaaacgaga tgaaaaaggg accatttcag gaacatataa 966001 agcgttaacg atttctgatg aaagcacgta tcaaacactg cagcaggcgc tgacgcaaac 966061 caaaacagct gtcggaacag cggagctcgg cgtgtcgcag gaaacgatta gcagccttta 966121 tgcgcctgtt actgtggggc agaaggcgct gaaagaaggg gcaaagtctg aggaagagct 966181 tggccagacg gtagggcttg tttacattat gctgttcgtc atttatttct cggtgattat 966241 gtatgccagc atgatagcga tggaggtcgc aaccgaaaaa tcttcgcgag ttatggaaat 966301 cctgatctca agtatgccgc cgatccagca aatgtttgca aagctgcttg gtatcgggct 966361 tgtcgggatc acacagcttg ctattattat aggagccggc tctctgtcgc ttaagctgaa 966421 ccaaaagagc gaaacggctt catctgtcgg cggattcctt aatttgaccg acgtatctgc 966481 aaccactgtc atctatgctg tcattttctt tttgctcgga tactttttgt acgcgacact 966541 tgccgcgttt ctcggcagtg tcgtcagcag aatagaggac gtgcagcaaa cgatcacgcc 966601 gatgacgctt ttggttgtcg ccggttttat gatcgcgatg ttcggtttga atgcgcctga 966661 cgcaggattt attacggtaa cttcgtttat tccgttcttt acgccaatga ttatgttcct 966721 gcgcgtcggc atgcttgata ttccgttctg gcaggcggct gtcggaatcg gaatcacact 966781 gctcaccatt gtcatactgg ccgttatcgg cgccagaatt tataaaggcg gtgtattaat 966841 ttacggcaat tcaagcgcgt tcaaagcgat caaacaagcg ctacgtttag cgaaaaactg 966901 attggaaaac agcctgggga ttctcaggct gtttctttat tgacagaacg tgcattcgca 966961 agaattcggt gctaaaataa gggtacttca tcctggaaag gagcagaatg ttgactgatc 967021 taacctttat tcatgcggca gatcttcatc ttgacagccc gttttacggg atatcgcatc 967081 tgccggagcc gatttttgcc cggattaaag aaagcacgtt tgcaagcgtg agacatatga 967141 tagacgccgc agtgagagag cacgttgatt tcattttgct tgcgggagat ctgtttgatg 967201 aagccaatcg aagcttaaag gctcagctct ttttgaaaaa acagtttgaa agactcagag 967261 agtgcggaat ttcggtatac gtcatctttg ggaatcacga tcatcttggc ggggagtgga 967321 cgccgattga atggcctgag aatgtccata ttttttcgtc cgctgttcca gaagaaaaat 967381 cgttttttaa agaaggcagg cgcatagcaa gcatttacgg cttcagctat caagccagag 967441 cattgatgga aaaccaagcc gcccgctatc ggagatcaac tgacgcaccg tttcatatcg 967501 gcatgctcca cggcacgctg tcaggatctg aaggacacga tccgtattgc ccgtttacac 967561 atgacgacct cgtgaaaagc gggatggatt attgggcgct tggccatata cataaacgcc 967621 aggttctatc tgccgagcat ccggcagtca tttacccggg aaacacgcaa gcacgccata 967681 taaaggagac gggagataaa ggctattatc tcgttcatgt gacaaacgga gatatatctt 967741 atgaatttca gagagcgcat gatgtcctgt gggaaaaagc ggcggttgat gtgacggagg 967801 caaagaatat gacagccctc ttccaaatgg tggaggacac gttttcgaag ctgcggaaaa 967861 aggggagccc tgtttgtgta aggcttgttt tacaagggac ggcgccggaa tggctgctgg 967921 aggcgccaaa aggcaccttg gatgagtttc ttgaagctct tcaggaacaa gaagcggaag 967981 aggaacgttt cgtttggcct cttagattgg acgatgagac agaaaacgaa gcaaacctaa 968041 caaaccttga tccttttttt ggcggtttat ttgaagacat tgatcgcagc gatctgtcag 968101 acgtgctgga agggcttgag cggcatccag tgtatagaag gcacgcggac cggtttagcc 968161 aagaggaggt aaaggaaata aaagagcagg cacagataat attgaaaaga cagcttaagg 968221 tgcttgatac atgaggcggt gacagctttg cgaattatat ctttacatat ctaccaatac 968281 ggaaaatttt ccaatcggac ctttgacttt tccgcctctc ctgtccaagt catctacgga 968341 ttaaatgagg caggaaaaac gacgatgatg tcattcattg aaagcatgct gttcggtttt 968401 ccgaaaacga aaaagtatga accgaaaaca ggcggtgtct acggcggtgt tcttgaagct 968461 gaacatcctg agtatggggt gctgaagatc gaacggacga aagggactgc cgaaaaacta 968521 agcgtgtaca cagaaaaggg cgaagtaaag cagggagatg ttttaaagca gctgttccag 968581 ggcacagaca ggtcgttgta caaagccata tattcgttcg acgtattcgg gctgcaggaa 968641 attcacgcct ttaatcggga caagataggg gaatttttgc tcttttccag cttgtttggt 968701 gctgaagccg tatcaaagct tgattcaagg ctgacgaagg aaagcgaaag gctctataaa 968761 ccaaatgggc gaaaccctca attgaatcag gagctggaaa cgcttaagca gctggcagtt 968821 aagctaaaac aggctgaagc agaggaagcg ggctatcatc agcttctcga ggaaaaacga 968881 acgcttgaag cccgccttgc agccgcggaa accgaattga aagagacggc gggacatatc 968941 cgaatgattg agggagcgat tgagcgaaag ccgctgctaa atgaaaaagc gacactcgaa 969001 caggtgattg cagaatttcc ggaacacgca ggacaatttc ctgctgacgg actgcatcag 969061 ctggaaaaat atgaatccca tcttcacccg aaatcagcac agcttgaggc gcttcgggtg 969121 aagatggcgg agttggacaa acagaggcaa aagcttatcc ccgataaaga actattggcg 969181 aaagaaacgc tgatacaaga gctttcggca gcgtttcata tgtaccaatc ctggggagaa 969241 cagctggcag ccattcaggc acagctgcgc cagacgtctg cgcagacagc ggcagggctg 969301 gaacagctca ataaaacgga tgaaaatgag ctcctgaata tgaacacctc atatgattat 969361 gaatggcagc ttcagcaagc ggtgcagcaa tatgtacagg caagagacag aaaacggcag 969421 cttgacgaga cgtttgaact tgcccggcaa gagctggaag acgcggaaaa ggccgttcgt 969481 gccgcttcgt ccgcgattct tgaaaacagc caaagaaaag ataaagaagc agctcttaga 969541 gcatatgatg aaacacaggg gcagcaccaa gagcaagcga agctcagaga acagctaacg 969601 ttttttgaaa gacagcaggc taaacagaaa aagactgtca ttgcagctgg tatgttgttc 969661 atcgttctct tttctctgct gcagcaatgg attcccgcca taagtttcgg cgctgcactt 969721 attgtgtatt ggcttgtttc aggaaagtcg tcttctcgaa acagccgaga gacaagacag 969781 cccatgacgg atatttcacc agcagaagct gaaatgctta gagaagcgtt atgggaggat 969841 gaccgcaata agcagcacct tctcacacag cgtgcagcgc tccagcaaaa agaggcggcg 969901 tatgaaaggg tcatccagca gtttgaacag tgggaagccg aaatggcgcc gtcctttaca 969961 caggttgagc gttttatgaa tgagctcgga tttaaggaag atccatcatt tttgcttgat 970021 gcatacagct taatgaagga tgttaaaaaa gaagtgaaga aaaagcatga gctgaccata 970081 gaagcaggca ggctgaaaaa gcaccggaga acattcgaag aacgcgtcag tatgcttctt 970141 cccgtgaatc agagtcagga tatctccatt tcggacgccc ttcacacatt gcggaaaaac 970201 attgaacgtg aaaaagaaat tgagaagcaa aaaaaggaaa ttgaaacaga tattcattat 970261 acaaaggaac agatgcttga acttgagcaa gaaatacagt atttccacgc acagattgaa 970321 cagttatttg ccgcggctgc tgcaaaagac agagatgcgt tttttgccat agccgccatc 970381 agcaggcaat tgaaggatac ggagaacaag cttcatcacg taaacgcaca gcttcaaggc 970441 gggtacccgg aggaacttga actggcggat tccaatacgc tttctgaatt gaaagataag 970501 caatttgttg agaatgaaag aaaagagcgg ctgactgagg agatcgagca gctccgcagc 970561 caaatcgcac tgctctcagt caaacaggaa caattagagg cttcgggaat ggtctcagac 970621 ctcaagcttc aaaccgaaat gcaaaaagaa cgtgtgaaag aaacggctaa aaaatgggcc 970681 tccatacaaa tggtcaaaca ggtgatcaga aacaaattgg agcggcataa aaaaatcgag 970741 cttccgcgcc ttctggagac ggcaggagaa tttttccgtc ctctgactga cggaaactac 970801 caaaccattt atttttccga aacggatgat tcgatcatgg ttatgcatcg cgatggcact 970861 gtctatcatg cggaagagct gtcacaaggg acgtgtgaac agctgtatac agcgatccgc 970921 tttgctttgg ccgttacgcg ccagggtgag tcaaagcttc cgttccagct tgacgacagt 970981 tttgttcatt ttgatcagga aaggctgaaa cgtgtattac atgttctgta tgatttatct 971041 gaaggcggta ggcagatttt gtattttaca tgccatgagc acgtaaaaga tgcatttcat 971101 agcagccaaa tcatccattt ggtgtcataa aagaggttct atagctgaaa atcggtatgt 971161 gatatactgg tattatgtaa gatacggagg gagctttaat agaatggcta aagggattat 971221 gctacatgag gttggcgaac aggtggacca gtatctattg attaaatcct cgacgaaagg 971281 gattgcaagc aatggaaaac cgtttctgac gctgatgctg caagaccagt caggcgatat 971341 tgaagcgaag ctgtgggatg ccaagcaaag tgatgaagtg acctatgcgc cgcagacgat 971401 tgtcaaggtc gtcggcgatg ttcaccatta tcgcggacgc acccagctga agctaagaaa 971461 tatcagaccg gtaagcgagc aagaaaacgt caatattgat gattttttag aaaccgcgcc 971521 gattccgaaa aatgaaatga tggataccat cactcaatat atatttgaaa tgaaaaatcc 971581 gaatatccag cgaatcacaa ggtttttggt taaaaaacac gaagctgagt ttatggatta 971641 tccggcggct acgaaaaacc accatgagtt tgtctcaggt ttggcgtatc atgttgtctc 971701 tatgctgaac ctggcgaaag caatagcaga tttatatcct tctcttgatc gtgatctgct 971761 ttacgccggt gttatcctgc atgatcttgg aaaagtgaag gagctgtccg gccctgtttc 971821 cacttcatat acggttgaag gcaatttgct cggccatatt tccatcatgg tgacagagct 971881 ttcaaaagcg gctgaggagc ttcaaatcga ttctgaagag gtgttaattc ttcagcattt 971941 gattttgagt caccacggca aagcagaatg gggcagcccg aaaccgccta tggtgaaaga 972001 agcggaaatt cttcactata tagacaatct ggatgcaaaa atgaatatga tggacagagc 972061 gcttgagcgc gtgaagccgg gcgagtatac tgaacgtgta tttgcactgg aaaaccgttc 972121 cttttataaa ccgacatttc ataaataact taaaaaggac tgatgctgac atattcagct 972181 cagtcctttt tgatgcgtct ttcccgcaca taactcgtct cattcccgca tatggttaag 972241 aataaagaat ctatgcaaag ggggaggagc ccgtgttatt ttttccgtgg tgggtgtatc 972301 tttgtattgt aggcatcatt ttcagcgcat ataaacttgt ggcggcagcc aaagaggaag 972361 aaaaagtaga ccaggctttt attgaaaaag aaggacagat ttatatggag aggatggaaa 972421 aggagcgaga acgccgcagt tctcagcagc atgaagaaga aaatcaaaac cattccatcg 972481 cataaaaaaa gctgtgcggc tcaatgagcc gcacagcttt ttttattatt tagaattgct 972541 tgaagatgaa gaagtgctgt tgcttgttga agatgtatta aatgtgtctt tcagatcttt 972601 atcttttact tcgatgtcag ccttcttcat gactttttga acagcttcct gaacagctgc 972661 gttgtcattt aatttttgtt caagcacttc agatttcagt tcttttttca tatcatcata 972721 tttgccgcgt tcttctgtct ttttaatgat atggtagccg tattgcgttt tgacaggatc 972781 actgacttca cctgttttta atttgaatgc agctttgctg aatgtttcgt ccatttggcc 972841 ttcttttgcg aaccagccaa gatccccgcc ttttgaagca gagctgtctg ttgagtattc 972901 tttcgcaagg tcttcaaact tctcgccttt tttcagcttt ttctctactt cttcagctgt 972961 ctttttatca gcaacaagga tgtggcttgc acggattttg ccttttaagc cttcccagta 973021 ctctttgata tcggcgtctg ttactttgat gttatcttta gccgcttttt gtgtcagcaa 973081 ttcatatttt acttgttctt tcaggtaatc tttgccatat tgcttttcga gggcagtata 973141 ttgatcgcca agctgcgttt tgtattcttt cagcttgttg tcaatttctt tatccgaaac 973201 tttatacttc ttgtccaata ctttttcttg cactagctgt gtcagtacgc ttgcgccagc 973261 tgttttcttc atgtttgtgt aaagctcgcc ttttgtgaca tcgcctgcgt ctgtttttgc 973321 gataacttct ttgtcgccgc tgctgcaagc actgagagcg aggatgcttg tagcagtgat 973381 agctgctatt gcgattttct tcattgtttt caaacactcc taatcattcc aaattaaatt 973441 acctatgcgt atcataacat attgtggctt tctgtaaaaa gattttaaat aaagggcatt 973501 cgtctagtca aacttttgct gatgacatac ttatatattg atcaagaaaa ggaggtatgt 973561 aacatgagcg gaggatactc taacggattc gcgttgctcg tagtactgtt cattttgctt 973621 atcatcgtag gtgcagctta catctactaa gcagcccgag gatcgcttgc aacataagcg 973681 atcctttatt ttcactagcg cctaatcgtt tcaaacatga attgcataac atgtaattgg 973741 taaataaagc ttattacagg aggtgctatt taagatgggt gaagtatttg caggcggatt 973801 cgctttattg gttgtgttat ttattttatt gattatcatc ggcgcttctt ggctgtacta 973861 atcaacataa aaaagcatag ctgcttaatc agcagctatg ctttctttcg tatttacact 973921 gtaaaggaga tctccacaaa cgaagagatc agtaaaatta atatagatac attaataaat 973981 cggaatacct tatcttgccg ctcttcagga atctctctga caaggcataa tgtattggtg 974041 agcctgttta tgaaatataa aataaacacg gcagccacga taaaatagaa taaaatgatg 974101 ggagattccc cctctctctg aactgtccca tattacatta ccaaatattt attaaaaaag 974161 atagaatgca aattgaaaaa tcgccaccag caccagggtt tgactacttt tcaacaagaa 974221 tatccaagcc gtcagcttcc tgatcaataa aagcggtttt cggtgctttt atcagcttga 974281 gagccagcag gaaatcaggc agacagtagc cggcgtgaat gcccgagatc atgcaaaaat 974341 aatgagcgtg attcggaaat gccagtgctg cgtaaaacaa taccggtgta atcagcaaga 974401 acgggctgac gagtgaaatc agcattgttg tttttggtat acgtttccat gtgcgcatgc 974461 gcaatatgta aaactttttt tctatttttc tttttttgca gatgattggc aggacatgga 974521 tgactttatg tacaaataaa ataacgacga gcaaaccgcc gaataaagat acatattcat 974581 cgcttaagct tgtgccaggc cgcagcagct caaaagctaa aaaggtagat ataaaaacca 974641 aaatcataaa acatacagca gttaatatta tgcgaacggc gccataatcc ttcatgagat 974701 ttatggtctt ccagcaattc atcaaagtca tccttccata catcttgaat agaatctcaa 974761 aataatttac tcctcccaag agaaaaaatc aatgcttttt taagaaaaaa tatcatccgg 974821 caggtatttt tttgaaacaa gcaaacaaac tgcgaaatat ggggttagaa ctttcttctc 974881 agtgaattat cagctaaaat aagattaaag atagaaagaa gtggtgtgga tggattcgat 974941 ggatcatcgc attgagcgat tagaatatta catacaatta ttagtgaaaa cagtagatat 975001 ggacaggtac cccttctatg cgcttctcat tgataaaggg ctgagcaagg aagaagggga 975061 agcggttatg aggatatgcg acgaattgtc ggaagagctg gcaacacaaa aagcgcaagg 975121 atttgtaacc tttgataagc tccttgcgct ttttgccgga cagctgaatg aaaaattaga 975181 tgttcatgaa acaatttttg ccctgtatga gcaggggctt tatcaagagc tgatggaagt 975241 ctttatcgac atcatgaagc attttgatta actgtttaca ggttcgagct cttcagccgg 975301 ttcatccgcc gcactgtcct ttgctttttt cttcaatttt ccgtttacgc tttcaaagtc 975361 attgtcaata ttggtgagtg acgtttcgaa aatttccata aaatcatcgc cgtagatatg 975421 gcgtatcata cacatcattt ctgccacttc aggaaatttt ccgaataaat gatataaagg 975481 ctgtgaccct ttaaaaacag cgttgcgtgt cggatcaaat tcctcaagca agctccagaa 975541 tacctcggta ccttcctcag tcaattggac atatgtgttc cgtttatcat tcagccgttt 975601 ggagaacctt aaatatcccc gttcttccag cttttttgaa aagttgaatg cggttgatac 975661 gtgcatgacc ccgaatttcg cgatttcaga aatggaagct ccattcaatt gatacgcaat 975721 ccataaaata tgatgctcat taatattcag gtcatacggt ttgagccatt gctgccaatc 975781 cttctcgatc gatttccaaa gagccttgct aagctgagcc attttctggg tgaaaaccag 975841 agcttctttc acatcatagg gcggttccac tcgattcatt acgtcacctg cttctctttt 975901 tctttttctc tattatgcca ataaaataaa gattaataaa gatgaaaatg taagaatttt 975961 ttaataaatt cacaaaccat tgcgacgaaa gggtttttcg gccaaaaaaa atacgggtcc 976021 aattttggcc cgcatttttt tcttttgaat aggatattag ttttgtaagg ttttctccag 976081 ctgtctgatt ttctcttcga tatcggcaat ttctttttgc agatcctgct ggtgaggctt 976141 gatctcttcc tgccattttt taattgatgt ttggagctcg ccgcccacgt ctttaataac 976201 atccgtgctt tcttttgccg ctttgatcag ctggtctttt aatgcaagcc cgtctgactt 976261 taagcgtttg attgtttctt caaaagaatc ataattggtt ttcatttttt cacgcagctg 976321 ctttcctgag gaaggtgcag taagaagaac cgctgctcct ccgatgatgc cgcctacgaa 976381 tagtcctgtt aatagagaac gtccgctcgc cattacaatc accccgtctt tttcttcaaa 976441 ataggattca ttcagcattt ttcatttttg ttgaaagcct gaacttctat acatagcttg 976501 ctttatttta gcatattttt taagtgaaaa ggagggagaa ggttgtctgt ctttttgatt 976561 gtattatcct gcatcaccct tgccttcgct tcaggcgctg tttactatat caaacttctc 976621 agccaggctg cttcttatcc gcccaagagg gttatccggc agaaagcgct tgtttgttca 976681 accggaaccg cctttacact atgtcttatc tttttcacaa aactcctcgc ttaaaacatg 976741 ctgacatgct gcgggcgctc tgttcaaaaa aacctctccc ggaagcggaa gaggttttgt 976801 gtgacaatta tttagcagct tccataaagc ttgaacgcct taaaatggtt tgcacaatcg 976861 gataaataat gatcattgag attgtattca gcacagcggc cggcagaaca acagccgcga 976921 acaatgcggc gaaaccgccc ggtaaaccga cgatcaataa agctgacgat agaaacacaa 976981 ttcctgataa gatggtcccg atcactgtca gcacagcggc tgcacctgtt ttccggctct 977041 ttctgaacaa gagaaacagg gagaagaaca gaaacgctga tacgggttta tcaatgatgt 977101 tagggatctg tccggctgga aacgcggttg taagcgcgga aatgattccg gtcacgatcc 977161 cgatgacgag tacattttgc acccgcggga acagcagaat gcccatgaac atcatgatca 977221 gcatcatatc tggtttcatg ccgcctaaaa agggcggaat aatggaatga agcgctgcgc 977281 cgattgcggc aaacagagcc ataatgacta actcttttgt tttcataact atgctctcct 977341 ctgctaagct ttttgccctc caataatatg ctcatcattt attgcgaagg ctttacagaa 977401 tgtgttatgc aaacagtata ccaaacggac ggtttgcata gccagacttt ttactcattt 977461 tcctgctgga atttcttcat gaacgcagct aatttttcac agtcttcgag agagaccgcg 977521 ttataaatag aagcgcggca gcctcccacc gaacggtgtc cgccaaggcc gatcatcttc 977581 gcatcttttg ctttctgaac gaatgttttc gttaattcgt catcccgaag cgtgaatgtg 977641 acattcatgc gtgagcggct gtcttttctg gcatgtcctt tatagaagcc gttgctttca 977701 tcaatacagc tgtagagaac ctgcgctttt tgttcattgc gctgttcaac agcttccaca 977761 ccgccgtttt ccttgagcca ttccagaacg aggctcagca tataaatcgc aaatgtcggc 977821 ggagtgttgt agagtgaatc cgctttgaca tgcgtggaat atttcaagat ttttgggacg 977881 ttcgcatttt cattttgcag ccagcttttt ttcatgatga ctacagtcac gccggaaggg 977941 ccgaggttct tttgggcgcc tccgtagatc acatcaaatt tggacacatc gatttttctg 978001 cttaaaatat cgctggacat gtcggctacg agcggaattg gagaattcgg aaactcctgc 978061 cactgagtgc cgaaaattgt attgttggat gtgatatgta aatatgcgcc gtcttttaca 978121 tccgtaaggt caacctctgg aatataactg taattgtctg tttcacttgt agcggtgata 978181 gacgtgttcc cgaacagttt cgtttctgcc agtgcttttt cagaccaagc gccggtcatc 978241 acaaaatgtg cggttttttc aggtgttaaa aagttcatcg gaagcattga gaattgaagg 978301 cttgccccgc cttgaagaaa caagatatcg taatcttccg gaatgcccat cagttcgatt 978361 aagaggcttt tcgctttttg gtgcaccgct tcatactctt tgctgcggtg ggaaagctcc 978421 ataacagaca tgccggattc gttaaaatca ataaattctt tctgtgcttt ttgcagaact 978481 tccagtggca gcgctgcagg acctgcgtta aaattcgttg tacgttccat tatgatctct 978541 ccctgttttc cacgttaatg tataaaataa tacaattatc ctatcacaaa aattcagttt 978601 tttgataaaa aattagaatt atcaaaagaa attgacggat gtttgcgaaa tgttcacaaa 978661 ataaaataac ctcatcttat gatgaggcca ggcgttttgc gatagaggaa gagatgttct 978721 gcagatcctc cggtttataa tcatcagcat gcgttttcca aaccgctccg aatccatctc 978781 cttttccgta gcgagggata atatgcatat ggtagtggaa cacagattgt ccagcttttt 978841 cgccgttatt gttcagcgta tttaagccga tcggttcaaa ttcatcccgg atagcgcggg 978901 cgatttttgg aacagcatgg aaatattgtt ttgctaattc atctgtaaat tcatatacat 978961 tctcaatatg tgttttcgga atgacaagcg tatggccttt tgtcacttgg ctgatatcaa 979021 gaaaggcaag tacatgttca tcttcataca ccttcgctga tggaatgtcg ccggcaataa 979081 ttttacaaaa gatacaattc tctgcacaat gcatgagggt tcctccttat gaaattgttt 979141 agtatgtata cattcatcgt accacagaaa tgcagaaaat agaaaacagg atgaacggcg 979201 agcgttcacc ctgaatgcag aggaagagct tatatgaaga aaatgtgtta tgcctttggt 979261 aagcacctca tttgtcaata aaatgaagac ttgtttaatg cctaacgatt cctgcgataa 979321 acacctcatt tgacaatttg cttcatacat gaagaattca tcaattcagt gaagagaaat 979381 ggtttgagca ttggacatgt ttattttcta tccaactgtt tctaagacgt ctttgacaaa 979441 cacctcattt ttcagttgat atgcttttcc tctacaactt ttatgatgtc cagaaccctg 979501 tctctttatg acagcaaatt catcatttgt taaaagggaa ttgtttcaaa tcaggccttg 979561 tttttggtac tatgaagaaa aacactataa ggggagaaac tatgtctctg ctatcggtaa 979621 aagacttgac cggcggatat acaaggaatc cggttttaaa aaacgtatca ttcacccttg 979681 aaccgaatca aattgtcggc ttaatcgggc tgaatggtgc tggtaaaagt acaacaatca 979741 gacacatcat cgggctgatg gacccgcata aaggttcaat cgaattaaac ggtaaaacgt 979801 ttgctgagga tccggaaggc taccgttcac aatttaccta tatacctgaa acacctgttt 979861 tatacgaaga attgacgctg atggagcatc ttgaactaac agccatggca tatggactgt 979921 caaaagaaac gatggagaaa aggctgcctc cgctactaaa ggaattccga atggaaaaga 979981 ggctgaagtg gttcccggcc catttttcta aaggaatgaa gcagaaggtt atgattatgt 980041 gcgcattttt ggcagagcct gcgctctaca ttattgatga gccttttcta gggcttgatc 980101 cgcttgccat taacgcgctg cttgaacgga tgaatgaagc gaaaaaaggc ggggcgagcg 980161 tgctgatgtc aacacacatt ttggcaacgg cagaacgcta ttgcgattcg tttattattt 980221 tacataacgg cgaggtgcgg gcgcgcggca cgctgtcaga gctcagagag cagtttggaa 980281 tgaaggacgc ggcgctggac gatttgtatc ttgagcttac aaaggaagac gctggccatg 980341 aataatatgc ttgatatttg gcagtcgcgg ctgcaggagc atatcaaaga aacaagaaca 980401 tacatgaaat atatgctcaa cgatcacctc gtcattgttt tgattttttt tctagcgggc 980461 gctgcaagct ggtacagcaa atggatacgg gacattcccg ctcactttcc gtccttttgg 980521 gtgatggccg tgctgttttc gctcgtattg acaagctctt atgtgcgaac gcttttgaag 980581 gaggctgacc ttgttttctt attgcctctt gaagcaaaaa tggagcctta cttgaagcag 980641 gcgtttgtct acagctatgt gtctcagctg tttccgctga ttgcgctgag catcgttgcg 980701 atgccgcttt atttcgcagt cactccggga gcttcgctcg tatcgtatgc cgcggtcttt 980761 gtccaactgt tgctgctgaa agcgtggaat caggtaatgg aatggcgaac gactttccaa 980821 aacgaccgca gcatgaaacg gatggacgtc atcattcgct ttgcggcgaa tacactcgtt 980881 ctttattttg ttttccaatc tgtttatatg tatgcgcttc tcgtctatgt cattatggct 980941 gttctttatc tgtatatgtc ttccgcagca aaacggaaaa catttaaatg ggagagccat 981001 attgagtccg aattgagacg aaagcagcgt ttctatcgga ttgccaacct gtttactgat 981061 gtgccgcatt tgcgaaagca agccaaacgc agagcttatc tcgacttttt gctgcggctt 981121 gtgccgtttg aacagcgcaa aacatttgcc tatatgttca cccgcgcctt tttgcgttcg 981181 agcgattatt tgggcattct tgtcagatta acgatcgttt tcgcgctgat cattatgtat 981241 gtctcagcca gcccgctgat tgccgcggtt ttgactgtgt ttgccatttt cattacgggc 981301 attcagcttc tgccgctctt cggtcacttt gaccatctgg cgcttcaaga gctgtaccct 981361 gtgcaaaaag aaacaaagct gaaaagctat ttctctctat taaaaactgc acttagtatt 981421 caagcgctgc tgatgtctgt tgcatctgcc tatgcagccg gcttgaccgg ttttctgtac 981481 gcgctgatcg gttctgccgt tctgattttt gttgttttgc ctgcttatat gacgaccagg 981541 ctgaaaaagc acggaaagct gtgaactgaa aagaggtaat caaatgacag ataatcagct 981601 gctgatgcag gaagctttgg aatggaaaat gcattttttg cgaaaggatt ccatgtttga 981661 acgcttttcg aagcgtgtcc agacgaaggt gaatgaacgg attcctgaaa aaatccatac 981721 ggtcgtcacc gagagtgtga aaaaaatggt agaagcgaca atggccggct ctaatatcat 981781 cacctataaa aaggatacaa gtgcactgtc gctcagtgaa aaaaacgaat tggcgaaaaa 981841 aacgattgtt tcttatcaaa aagtggcagc tgctgaggga gtcggcaccg gagcgggcgg 981901 cattttttta agcattgctg attttccgct gctgctttca attaagatga agtgtttatt 981961 taccttgtct tccatttacg gctttgatgt caaggatgca caagaaagga tatttttgct 982021 gctcgtgttt cagcttgcgt tttcgagtga tgatggccgt aagtcgcttt tttctgtcat 982081 cgaaaattgg gagacggaga aaaagagcat cgactggaga gtgttccagc aggaatatcg 982141 cgattatatc gacgtcgtga agctttttca gcttttgccg ggcgtaggag cggcagtcgg 982201 cggaattgcc aattataagc tgcttgctca gcttggagaa acggcaagac atgtttttca 982261 tctgaggata ttaaaggaaa cagccggaga ataaacactc cggctgtttt tttatagctg 982321 atgataggtg atcgcagcgc cggcaaggac cttggccgct gtcagcatgg ctttttcgtt 982381 gatatcaaat ttcggatggt ggtgggaata gactcgctct ggctgttcgg gagcggcgcc 982441 tgtaaagaaa aaagtgccct tcacgttttg taagtaataa gcaaaatcct cgccgcccat 982501 ttgtggttca ccgtcaatga cctgctgaac gccctcggta ttctttgcgg tgctcaccaa 982561 gtggttcgtt tctgcaggat ggttcacaac cgctggataa ccctgttcat aggtgtactc 982621 ataggacgcg ccgtgcatgc tgcatattcc ttttacaacc gcttcaattt ctttctccag 982681 aatgtcccgg acattttcat caaaagaacg cgctgtgccg atgagtactg cttggtctgc 982741 gatgacatta aacggattgt cggcgatgaa ggagcctgtc gaaatgacgg cggattgaat 982801 cggattgact ttgcggctga caatgtgctg caaagaggaa acgatttgcg aaccgattag 982861 gacggcgtct ttagtatcat gcggatgagc gccgtggccg ccctttccga agactttaat 982921 cgtaaatcgg tctgccgccg ccattacggc gccggggcgg cagagaatag ttccgagcgg 982981 ctcagttgcc caaagatgag tgccgaatat cacatccgtg ttttcgagac atccgtcatc 983041 aatcattggc tttgcgcctc caggataata ttcttctgca tgctggtgga tcatcacaaa 983101 tgttcccttc agttcatgtc tgttttggtg aaggaccttg gccactgcga gaagagctgc 983161 ggtgtggccg tcgtggccgc atgcatgcat gacaccaggc actttggagg cgtaagggac 983221 atctttttca tcttgaatgg ggagagcgtc aaagtcggcc ctcaaagcga ctgtagggcc 983281 gggttcgctt ccttctatat ttgctaaaac ccctctaccg ccaacgtttg tgcggattgg 983341 gactcctaac gattcataat aggaagcaat aaatgcggcg gttttttctt cttgaaatga 983401 gagctcagga tacatatgaa aatggcgcct gatctcaacc atttcttcaa aacagccgtc 983461 gagctgtttg tttatctctt tctgcagtgt ggatatggac aaagccgctt cccccttttc 983521 tatgcttttc catgattgta tagaaaaagt ctgaatattt caactcatgc tgttttaaag 983581 catcatcaca gctgcgaggg ttgtcaccaa aaggccaatc gcgacgggaa tgaagttttt 983641 tctggcaagc tcaaaaggat caactttgca aatggccgcg gcgggaatca aagcccatgg 983701 gaccagtgtt cctccgccca cccagatggc agagatttgt ccgagcgcgg tcagaatagc 983761 gggatcggca tggagagcgg acgaaaagag ctttgcgatg gagccggcga gagaaatgcc 983821 agaaaatcct gagccgtcaa ggcctgttat ggctccagcg gcagttaatg cagtggcggc 983881 aagctccttt gacataggca tcatatggga taaagcaatg ccaagatcgt tgacaatgcc 983941 gtgggaacct ttagggagtg aagtgcccag tatgctttca tagcctgagt cgccaagata 984001 aaagaaagcg gcaatcggga tgacggggcc gaaaacctta aaaccgaact taaatccgtc 984061 aataaaatag ccggtgattt tttcaagccc tttatgctta tacacgaaaa aatgaacggt 984121 aaagaggata caaattgcag acccgccaat taacgcggtt gcatcatttc cttgtaggtt 984181 aaacaagagc atgcaggcga tatctgcaag aaaggcaagc ggaatcaaaa aagccagtat 984241 ggaccgcagg cgttttggca agtacagcga gttgtcttgt tcgccggaaa gaacggggga 984301 aaaagaagtg ggatgctcct gttttttgcg ttcgcgctga atcatgataa aggcagcagt 984361 tgttgttgtc acacccataa tcagcacaag cggaatactg gccgagacga catcaccgac 984421 tggaatgcct gctgcatccg cagtcagctt tggcgccgcc tgaatgacaa agtctcctga 984481 cagggcaaaa ccgtgtccga ataagttcat ggccatggcc gcggcaagag gcgtcaaacc 984541 ggcacgtgcg gctgcgggga gcaggacggc gccgatcaaa gcgacacccg gagaaggcca 984601 gaagaataga gaaatggcga acatcaggcc tccaatcagc caataggcag tcacaggccc 984661 tctcacaagg cttgcaaagg gagaaatcat cgcttcattt atccctgttt ttgttaacaa 984721 atcactcatt gaaacgataa agcaaatgat gaaaatcgtg ggcagcagtt cgccggccgc 984781 atagataaag ctgtggaata aactgctgac agaagctgaa agtgaatggc tggcccatag 984841 cgatatgata aaaatgccga atagagaaat aaatgtcgtg tcttttctca gcagcataaa 984901 taggataatt gcaccgataa aaaacacata cagaacatgg acaggcaaaa tcccgacttc 984961 catcatcgat cactccttcc gcttacagat tattcatagg cgggcggaag gtgccgggac 985021 agaggggagg gttatgatgg aagatgaaca ttgatctgtt tcagctgctc aatcagatga 985081 tgccttaatc ctctattcgc tttttgcaga tgttttggga agcattcagg agaaaaaatg 985141 acgcaccctt cagcaagcca gttttttcta taggcgatga tgctttccga tggctctata 985201 tgagttatcc tcgtgctgca tctcgtactc atcaaatccg aactgaaaac cgcagcacgg 985261 gcagatttca tgagaatgat tgccttcatg atcatatggc ggttcagcca atccttaaac 985321 ccgcagactg ggcaagtatg cttcattttg ctttcctccc aataaaataa gctgccggac 985381 atgccggcag ctattcgaca gcgaaatatg tggtgacata ggaaggccgg gagaagatcg 985441 acgttgtgtc aattccggca gatgtatcgc gttttttgtg ggcttctttg taagaaccgg 985501 actgctgcca gtcttgaaag gcgctttccg tttcccacaa ggtcagaatg acataggtgt 985561 cactgtcaag cggacggagc actcgaattg cttcaaagcc aggctcgttt tcgacttttc 985621 ccgctctgtt tttaaatctg ttttcaaaca gcggacgccc ttcctgagta acggcaatat 985681 tgttcaatac tgcaaaaccg ggatgtttga tctctccgac ttggtcaatg acttcataag 985741 cgtgtggtgc ctggaaaacg gtatctccgt ttgtttcatg aattaaaatg gcgttttcct 985801 gcccctgcat caaaaggata ttttctgagg gatgcttctg tacgatcgtt tttaaaaaat 985861 cggctgtccc atatgtaata taaaccttca tatcagccac ctcctgcttg ctagtatatc 985921 aaaacaatgg tataagtttc tattggcgag tgcttcgaac ataattccaa acaatttttc 985981 ccatactacc tttagaaagg cgaggtgagt tcatgtttaa gataaagaaa aagaaacttt 986041 ttatacctat cattatttta gtgttaactg cttttctcgc tttaatagga tatatttcaa 986101 ttatttttct cggccattat gtcatagatg aaaaaaagct tattcttcat gcttcttcaa 986161 aaattgttga tcaaaacgga gatgaggttg caagcctgta tacagaaaat cgcgagccgg 986221 tctcgatcaa tgagattcct aagcaggtca gagaagcgtt tatcgctgtt gaggataaaa 986281 ggttctatga gcatcacggc attgatgcaa aatccgtcgg aagggcagtg taccgcgata 986341 tattagcagg cggaaaggtg gaaggcggaa gcacgatcac ccagcagctt gccaaaaata 986401 tttttctgac acatgacaaa acatttctaa gaaaaacaaa agaagtgatc attgcgatta 986461 atcttgaacg ggattacagc aaggacaagc tgcttgaaat gtatttaaac cagctttact 986521 tcggacacgg ggtttacggc atacaagcgg cgtcccacta ttattttaat aaagaagtaa 986581 aagatttgac tgtatctgaa ggcgctgttt tggccgctat tccgaaggcg ccttctacgt 986641 actctccaat tttgcaccct gataaaaata aggagcggcg tgatacaatt ctaggtatga 986701 tgaatgacca aggctatatc agtgcgaaag aggctgtcac cgcacagggc cggacgcttg 986761 gactgcatgt gaagaaacag tcggaaacac cttggtttga cagctacatt gaccttgtga 986821 tcaaagaggc ggaagacaag tattccattt ccggagagca gcttcttcaa ggcggataca 986881 cgatcaaggt gccgctcgat tcgaagctgc agaagacggc ttaccaggtg atgaaagagg 986941 gaagctatta tcccggaaca gatcagaatg ccgagggaag cgcggtcttt attaataaca 987001 agacaggcgg tgtagaagcg gccatcggcg gaagggatta cacatccaaa ggatataacc 987061 gtgtcacagc tgtccgccag ccgggttcca catttaagcc gcttgctgta tacggaccgg 987121 cgatgcagga aaagaaattt aagccatatt ctctattgaa ggatgagttg cagtcctacg 987181 gagattatac gccgaaaaac tacgacagcc ggtatgaggg cgaagtcact atgtctgacg 987241 ccattacgta cagcaaaaac gcgccggctg tctggacgct gaatgagatc ggcgtcgaaa 987301 cagggaaatc ttatttgaaa gcaaacggca ttgatatccc tgatgaaggc cttgctcttg 987361 ctctaggcgg cttggaaaaa ggcgtttcac cgctccagct tgccggcgcg tttcatacat 987421 ttgccgcgaa tggaacgtat actgaaccct tctttatctc gagcataata gatgaagacg 987481 gagaaacaat agccgatcat aaagaagaag gaaagcgggt attcagcaag cagacgtctt 987541 ggaatatgac gagaatgctg cagcaggtag tcaaaaaggg aacggccacg tccggcacct 987601 atcacggcga cctggcggga aaaacaggtt caacatctta tacaggcgtc tccggcgcga 987661 caaaggacgc ctggtttgca ggctatacgc cgaaaataac cggggcagtc tggatgggct 987721 atgacaaaac ggatcaaaac cattatttga aagccgggag ctcatacccg acgcggctgt 987781 ttaaggatat tttgacacag gcaggagaaa ccggtcatgt gttcacaaag cctaaaaacg 987841 ttaaagaact ggaaagcccg attgagctga agccggtcaa aacactcaca gccgattaca 987901 catttaaagc agcggggctc tttactattg aattaaagtg ggacgctcaa gaggatgatc 987961 gggccgtata cagaatttat gtaaacaagg acggcgagga gacgcttctt gattcggttg 988021 aagggaaggg aagctatgaa attccttatg ccaacttatt ttcgggcgcg tcttataaaa 988081 ttgtgcctta taatacacag acaaaaagag aaggggaagg aaccgattac gttcagccaa 988141 aattgttttc ctcttaatgg aattcggcga ttttttgaac tttgagctac atttctatac 988201 catttgccta aaacaaggta tagtgtaata agtcaagaaa tacgaacgta tggttgccgt 988261 atgaaaggtg gaaatcagat gagtaaacga gaaacgttta acgagacgtt tttaaaagct 988321 gcgcggggag aaaaagcgga tcacacgcct gtgtggtata tgaggcaagc agggcgctca 988381 cagccggaat accgcaagct gaaggaaaag tacggattgt ttgagatcac acatcagccc 988441 gaactttgtg cgtatgtcac aagactgccg gttgagcaat acggagtcga tgctgcaatc 988501 ctttataaag atatcatgac gccgctgccg tcaatcggtg tggatgttga aatcaaaaac 988561 gggatcggtc ctgtgattga tcagccaatc cggtctctgg cggacattga aaaactcggc 988621 cagattgatc cggaacagga cgtgccgtac gtgcttgaga cgattaaact gcttgtcaat 988681 gagcagctga acgtcccgct catcggtttc tcaggtgcgc cttttacgct tgcaagctat 988741 atgatcgaag gcggcccgtc gaaaaactac aataaaacaa aagccttcat gtacagcatg 988801 ccagatgcat ggaatctgct gatgtccaag cttgccgaca tgatcatcgt gtacgtgaaa 988861 gcgcagattg aggcaggcgc aaaagcgatt caaatctttg attcgtgggt cggcgcattg 988921 aatcaggcag attacagaac atacatcaaa cccgtgatga accggatctt ttcagagctc 988981 gcaaaggaga atgtgccgct gatcatgttt ggcgttggcg caagccatct tgcaggtgat 989041 tggcatgacc ttcctctcga tgttgtcggg cttgactgga gactcggcat tgatgaagcc 989101 agatcaaaag gaattactaa aacagtgcag ggcaacctgg acccgtccat tttgcttgcg 989161 ccatgggaag tcattgagca gaaaacgaag gaaatacttg atcagggtat ggagtcagac 989221 ggcttcattt tcaatcttgg ccatggggta tttcctgatg tcagtcccga ggttttgaaa 989281 aaactgacag catttgtcca tgaatattca caaaacaaaa aaatgggtca atattcctaa 989341 gcatatcttt tggtatctta atgatatcct gtcaaaatgt ttgtatcaga tcattaaaga 989401 gggtgtaaac agtgagtaga aagaaaatgg ggcttctcgt gatggcgtac ggcacgcctt 989461 ataaggaaga agatattgaa cgttattata cacatatcag aagaggcaga aagcctgaac 989521 ctgaaatgct tcaagatttg aaagacagat acgaagcgat tggcggcatt tcaccgcttg 989581 cccaaatcac agaacagcag gcgcataatc tggaacagca cttgaatgaa attcaggatg 989641 agattacgtt taaagcgtat atcggactga agcatatcga gccgtttatt gaagacgccg 989701 tagcagagat gcataaggat ggcattacag aagcagtcag catcgtgctg gcgccgcatt 989761 tctccacgtt cagcgttcag tcctacaaca aacgcgccaa agaagaggct gaaaaactcg 989821 gcggcttaac gattacgtca gttgaaagct ggtacgatga accgaagttc gtgacatatt 989881 gggttgaccg agtgaaggaa acatatgcgt caatgcctga ggatgaaaga gaaaacgcaa 989941 tgctcatcgt atccgcacac agcctgccgg aaaaaatcaa agaatttgga gacccgtacc 990001 cggaccagct tcatgaatcg gcgaaattaa ttgctgaagg cgcaggcgtt tccgaatatg 990061 ctgtcggctg gcaaagtgaa gggaacacgc ctgatccttg gctcggaccc gatgttcagg 990121 atttaacacg tgatttattc gaacaaaaag gctatcaagc atttgtatat gttcctgttg 990181 ggtttgtcgc ggatcactta gaagtgcttt atgataatga ttatgaatgc aaagtggtta 990241 ctgacgatat cggcgcaagc tattaccggc cggaaatgcc aaatgccaag cctgaattta 990301 ttgatgcttt ggcaacagtc gtattaaaaa aattaggacg ttaaagaagg cgatgaacat 990361 gagtgacggc aaaaaacatg tagtcatcat cggcggcggc attaccggtt tagccgccgc 990421 cttctatatg gaaaaagaaa tcaaagaaaa gaatctgccg cttgagctga cacttgttga 990481 ggcaagtccg agagtcggcg ggaaaatcca gactgtcaag aaagacggct atatcatcga 990541 aagagggcca gactcatttc tggaacgaaa gaaaagcgcc ccgcagcttg ttaaagactt 990601 aggtcttgag catttgcttg tcaacaatgc gaccgggcaa tcctatgtgc ttgtaaaccg 990661 caccctgcat ccaatgccga agggcgctgt aatggggata ccgacaaaaa ttgcgccgtt 990721 tgtttctacg ggtctgtttt ccttgtccgg gaaggcgaga gctgctatgg atttcatcct 990781 gcctgcaagc aaaacaaagg atgatcagtc attgggagaa ttcttccgca gacgtgtcgg 990841 agatgaagtg gtcgagaact taatcgagcc gctactatca gggatctacg caggcgacat 990901 tgacaagctc agcctgatgt cgacatttcc gcaattttat cagacggaac aaaagcatag 990961 aagcctgatt ctcggcatga aaaaaacaag gcctcaaggc tcaggccagc agctgacggc 991021 aaaaaaacaa gggcagttcc aaactctgtc aaccggtttg cagacccttg tagaagagat 991081 cgaaaagcag ttaaagctga cgaaggtgta taaaggcaca aaagtgacca aacttagcca 991141 tagcggctct tgctattcgc tcgaactgga taacggcgtc acacttgatg ctgattcagt 991201 aattgtgact gctccgcata aagcggctgc gggaatgctt tctgagcttc ctgccatttc 991261 tcatttgaaa aatatgcact ccacatccgt ggcaaacgtc gctttaggtt tccctgaagg 991321 ctccgtccaa atggagcatg agggcacggg ttttgtcatt tcaagaaaca gtgactttgc 991381 gatcacagcc tgtacgtgga cgaataaaaa atggccgcac gcagcgccgg aaggcaaaac 991441 gctgcttcgg gcatatgtcg gaaaagccgg agacgaatcc attgtcgatc tatcagataa 991501 tgacattatc aacattgtgt tagaagactt aaagaaagtc atgaacataa acggcgagcc 991561 ggaaatgaca tgtgtaaccc gatggcatga aagcatgccg cagtaccatg tcggccataa 991621 gcagcgtatc aaggagctgc gtgaagcact tgcatctgcg tatccgggtg tttatatgac 991681 aggcgcttct ttcgaaggtg tcggcattcc cgactgcatt gatcaaggaa aagctgccgt 991741 gtctgacgcg cttacctatt tattcagcta aaacctccgc tttatcgcgg aggttttttt 991801 gatgtgcaat ggcaatattg tgtaaaaaat gattgaattg aacagcaggt tatgatacat 991861 ttgcatatgt acttaatgac taaaatgttc aaacggtcag tttcgaggtg aatacaatgt 991921 caatagatcg aaaaaagctc attttggagg cggctacaaa gtctttcacg cagttcgggt 991981 ataaagcgac gacaatggat cttgtcgcaa aacttgcgaa cgtggggaag ggaaccattt 992041 atactttttt caaaaacaaa gaagagctgt ttgacgagat tttcactact ttattaaagg 992101 aaatgaagca aaaagcggat gaagcgatgg agccgagcct tccgttccat gaaaatgtgc 992161 acagagcgct gtttgccatt ctggagttca ggaaaacaca tcagctgacg attaaaattt 992221 tccaagagaa tgccgagatt ggtacaatgg cagttcagga agtgatccag aaaatggagc 992281 gatccatcct gtcttatatc aaaagcaaga ttgaagacgg gatcaaaagc ggcgcaatca 992341 agccgtgcga ccctgagctg acagcctttg tgatgctgaa gctttatatc gcgctcattt 992401 ttgactggga aaaacaacac cccccgcttg ataaagagac aattgcggga ctgcttgaat 992461 tgtatgttgt caaaggattg tcagcgaact agataatcct ttctctttgc aagaaaatga 992521 ccatttttta tgatgagtca gttttagaat ggaggcatca ggatgaacac aatacgaagt 992581 cagtggaaag acatcgtaac aagtaaaaaa ttattgattc ccatcatcgc cattttgttt 992641 gtcccgctta tttacagcgg cgtattctta aaggcttatt gggacccgta cggcacagtt 992701 gaccagctgc ctgtcgttgt cgtcaaccaa gacaagggag caacgtatga aggagaaaaa 992761 cttcaaatcg gtgatgatct ggtcaaagaa ttaaaggata ataacaactt tgattggcat 992821 ttttccaatg atctcgacca atcgttaaag gacttattga atcaaaaata ttatttagtt 992881 gtcgagattc ctgaggattt ttctaagaat gccagcactg tattagacaa aaatccgaaa 992941 aaattggatc tgaaatacca tacaaatgca ggttctaact atgtaggggc aacgatcggc 993001 gaaaaagcga ttgataaact gaaagcctct gtttcaaaag aagtgaccga gcaatatacg 993061 aaagttattt ttgataactt taaagatatc gcaaaaggtt tgagcgacgc gagcagcggc 993121 gcgaaaaaaa ttgatgacgg cacaaaggat gcgaaaaacg gaagcgccca gctgaaagaa 993181 aatctggcga agctgaagga aagcaccgct accatcagtg acaaaacagc gcagcttgca 993241 gatggagcgg ctcaggtgac gagcggcatc caatcacttg acagctcgct cggtaaattc 993301 caggacagca gcaaccagat ttatgataaa tctagtcagc ttgcagcagg atcaggcgag 993361 ctgacaagca agatgaatga acttcttgcc ggacttcaaa atgtgcagaa gggtacgcct 993421 aatcttacta acgggttgga tcagctcaac agtaaagtcc aagaaggttc tgagaaagcg 993481 gcaaaagcgg aaaagatcat taatgcgctc gatttaacga agcttgaaac tgctgtaaac 993541 aatctggaaa agtcagaaac tgcgatgaag gaattcaaaa aacagctgac tgactttgaa 993601 aacagtttga aaaaccgtga tcaggcattt aaaaatgtca tcaattcgag tgacttctta 993661 acagcggagc aaaaaagcca gctgattaat tctgttgaga aaaagcttcc gcaagttgat 993721 gcgcctgatt ttgatcaaat attaagccag ctacctacag ctgatcagct gcctgacatc 993781 gcaacgataa aaagctctct tgaagacgtg aaagcgcagg tggcgcaggt gaaagccatg 993841 ccggaagcta catctaagct ttataacggc gcaaaaacaa tccaagatgc gattgacaga 993901 ttaactgagg gagctgataa gatatacaac ggttctcaga agctgacaga tggccaaact 993961 aaactgacag cgggcatcgg tgaatataat aagcagttcg caaaagcaaa agcgggctca 994021 gagcaattgg tgacaggaag cagccaagta tccggcggat tgtttaagct gttagacggg 994081 tctaaacagg tccaaagcgg atcatcaaaa cttgcagacg gatctgcatc acttgataca 994141 ggtttaggca agctattgga cggcacagga gagctgtcta gtaagctgaa ggatgcggct 994201 gaccaaacag gagatatcga tgctgatgat caaacatacg gcatgtttgc ggatccggtt 994261 aaaaccaaag atgatgccat tcattccgtt cctaactatg gaacagggct gacaccttat 994321 atcctgtcaa tgggcttgta tgtcggcggc atcatgctga cggttgtctt cccgctgaag 994381 gaagcgtcag gacgtccgag aaacggtttt gagtggttct tcagcaaatt caatgtcatg 994441 atgcttgtag gaatcattca atcattgatt gtggcgacgg ttcttctatt gggaattggt 994501 cttgaggtag agagcacgtg gagattttac gtgtttacga tcattacgag tctcgctttc 994561 ctggcgataa ttcaattttt ggctacaacg atgggcaacc cggggcgatt tatcgcagtc 994621 attattttag tgctgcagct gggagcgagc ggaggaacct tcccgctgga attgcttccg 994681 aatttctatc aggtcatcca cggcgcattg ccgatgacct acagcattaa cggattcaga 994741 gcagtcattt caaacggtga ctttggctac atgtggcaga tggccggcgt cttaatcggc 994801 attgccctcg tcatgattgc actaagcatt acttacttta caatgttaag ccggaaggaa 994861 gaaacatcag aagaacagcc ggcttcataa agaaaaagaa cttgtttcct tggaaacaag 994921 ttcttttttt gttacatccc ccatttaata agcaatcctg tataggttaa tccgccgcca 994981 aacccgaaaa gcaaaacgat ttgatctttt ttcagcttcc cggctttcac tgcgagatcg 995041 agcgccaaaa caattgaaac cgaagacgtg tttccgtagt gctcaacact agtgagcgtt 995101 ttttcaatcg ggaacggtgt tttttcacaa attgactcga tcatgcgcaa gttggcgctg 995161 tgaggaacaa accaatcgag atcatcggag ctgagtcctg ctttatgtaa aagccgttca 995221 aattcgccag ggacggttct tgcggcccat ttatatacct cgcgtccgtt ttgcaccatt 995281 tttccggaac cgacaagctg cacaccgttt atttcatttc gcagtccggc acgatacaaa 995341 atatcgccgc cgttcccgct tgttccttgt acagacgcaa gaaatcccgg cgtctcttca 995401 tctcgttcta ctaacagcgc acccgcggca tcgccgaaca gtacgcatgt cgttcgatcg 995461 gtataatcgg ttacctttga taacgtctct ccggcgatga cgagaatttt ttgatgaagg 995521 ccagatgtga tcaatccatt tgccaaatgg aggccgtatg tcagcccggc gcatgtcgca 995581 ttaatatcca gcgcgccggt gctttcccag ccgaaatatt cctgtacgcg gcatgccgta 995641 ctcggaaagg cgtaatcgga tgtggttgtg gcaacgagga tcatatcgac atcatcaagc 995701 gttcctttat aacggctctt gagattcttc accgcttcta tgcataaatc agaggtaaat 995761 tgatgttcat ccgcaatccg gcgttctctc attcctgtgc gctgaacgat ccattcatca 995821 gaggtatcaa cgatcttttc taaatctgca ttggttaaac gtctgctcgg cgcataggtg 995881 ccgatagctg taatttttgc ttttgacata tgaatcactc cttatggtca gattataaca 995941 ctagatatta gtatctggta ctaaaaagaa ggttttttta caaaaaaaga gaagtgtaga 996001 taggaatcta tgaaaaagaa aaaggaggct gaaaaatggt cagtcaagaa gcagtagtct 996061 ttttggcatt atccggggct attgcgtttc tgttgccaat cgggctgatt gtatggttta 996121 agcgaaagta tggtgcctcg cttaaagtgt tttttattgg cgctctcacg ttttttgtct 996181 tcgctcagct gctggaaggc ggcgttcatg tttatgtact gcaagtgaat gaaatgacga 996241 aagaagcgat gcagcatcca ttatggtatg gcatttacgg ctgcttgatg gccggcattt 996301 ttgaggagtg cggaaggtat ttgatgatgc gattttttat gaagcgccat catacttggg 996361 cagatggtct ggctttcggg gcaggccatg gcgggcttga agccatcctg attacaggct 996421 tgtcctctat ctcacttatt gtatacgcat ttgcaatcaa tagcgggacg tttgaacagc 996481 ttttggtcaa tggcgacgtc aaacaggcgc ttttgccgat acaggagcag ctgctgcata 996541 ctccttcgta tgaatggatg ctgggcggaa tagaaagaat cagtgccatt gccgtccaga 996601 ttggtctgtc tctgcttgtt ttgtacgcgg ttaaaaaccg ccggccgctg tttttgctgt 996661 attctattct tttacatgca ctgtttaatg tcccggcggt tttatatcaa agaggaatca 996721 tagagcatgc tgcagctgtt gaaatcattg ttgctcttat agcggcttta tcagtttatt 996781 ggattgtaaa agcaaaaagg gtgtttcaat aaaaggtcca agcagcagca atgcccgctt 996841 ggaaaaatgt gaatggaaat attcattaag catgggtcat cagaatattt ctgattcagt 996901 ctttagcaat gacagcaaga atgtctgtgt tttttacaag agaaacaatg gtgtttcttt 996961 ttcttcttct cgcaagggtc atggcattct ttctttttct tgcaatggtc gtggaaatct 997021 ttatcgaacc actcgtcaaa gaaccaaaaa tcatcgaacc aatcgtgaca acgacatttc 997081 tgttcatgtg aatgacgaca gcacatagaa atccctcctc ttcccatgct ctctacagca 997141 tatgagagat tgataggaaa agattggacg ggtccctcgg gaaaagagta tattttaagt 997201 agaaaataaa aggaggaatg ccctatgacg tccgtacgta aaacgatgga gctcattaaa 997261 gaacttgtat cgatcccaag cccgacagga aatacatatg aggtgatcaa ttatattgaa 997321 agccttttaa aagaatggaa ggtagaaacg gttcggaacc acaagggcgg cttaattgca 997381 acgcttccag gacgcgacac atcccggcat cgcatgctga cagcgcacgt tgacaccctc 997441 ggcgctatgg tgaaggaaat taaagcggac ggccggctga aaatcgactt aatcggcggg 997501 ttccgctaca actcgattga gggggagtat tgccaaattg aaaccgcctc gggaaaaatg 997561 tacacaggca caatcttaat gcatcaaacg tctgtgcacg tatacaaaga cgcgggaaag 997621 gctgagcgga atcaagagaa tatggagatc cgcctagatg aacctgttca ctgccggaaa 997681 gatacggagg agcttggcat tggcgtcgga gactttgtgt cgtttgatcc acgtgtcgag 997741 atcacatcaa gcggatttat taaatcgcgc catttggatg acaaagcaag cgtcgcctta 997801 ttgctccgct taattcatga aattcaaaca gaagacattg agctgccgta tacaacccat 997861 tttcttattt ccaataatga agaaatcggt tacggcggga attcgaatat tcctcctgaa 997921 acagttgaat atttggcggt tgatatgggc gctatcggtg acgggcaggc gacggatgaa 997981 tattcagtat caatctgtgt gaaggatgcg agcgggccgt atcattatca gctcagaaag 998041 catttagttc aattagccga gaagcatcat attgactata agcttgatat atatccgtac 998101 tacgggtctg atgcgtcagc agcgatcaaa tccgggcatg atattgtgca tggcctcata 998161 gggccgggaa ttgacgcttc ccatgcattt gaacgcaccc ataaatcatc tcttcgccat 998221 accgctaagc ttctgtatta ctatgtacag tcaccaatgg tataaggggg aggaccaatg 998281 aagatttata agctgaaaag cacattcggt tgggaaggtg atgacgggtt gggagaacag 998341 ctgattcagc agatccttgc cggagaaaaa agcgccacgt gcgcgccgaa atcattgtat 998401 tcaaaagatg aattgaggga cgtttatcaa acagcgggtc agcttgttac cgtttatgat 998461 aaacatgaca atccaagatg caatataaaa gtaacagatg tctttgaaac cacctttggt 998521 gcgcctgata tgaggttagt caaaggagag ggcaatggag accgaattga ggagtttcaa 998581 gaggatcatc ggatggcatg ggcggaactg atcaaaagcg gtgaactgga gctgaatgag 998641 gatactgttt tgattacaga gttgtttgtg cttgttaaag attaaaaaag cctgcggggc 998701 aagaaccccg caggcttttc attaaccaga aatggttgcg ttttgttctg ttttcgattg 998761 ggacataaca gtttctgctt tcgcaggatt aaacatgcct tcccatttag acatcacaac 998821 ggcagcaagc gcgttaccag tcaggttgac aactgtacgt gccatatcca tgatgcggtc 998881 tacgccggca ataaaggcaa gtccttcagc cggaacgccg atggtgccaa gcgttgcaag 998941 caagacaaca aaagaagtac caggtacggc agccatccct ttggatgtca ccattaagac 999001 gagcacaagc gtaatttggt gccaaatcgt caaatcaatg ccatatacct gtgctaaaaa 999061 gagtgcggca atagattgat agagaacgga accgtctaag ttaaacgtgt aaccgatcgg 999121 aatgacaaat gaaacaatgc cttttggaca tccgattttc tccatttttt ccatgatacg 999181 cggaagaacc gtttcagagc tggacgtact gaacgccagt aagatttcgt ccttcatgta 999241 agcaaggaac ttgaagatgc tgatgccggc aatttttgcg acaatcccga aaataacaat 999301 taagaagaaa gcaagcgcga cataaaccaa tccgacgagc tttccgagag agataagaga 999361 accgagtccg aatttagaca cagtcactcc gataagagcg aaaacgccga atggcgccac 999421 tttcatcaca aggtttacaa cgtggaacat ggcatgggat acaccttcaa aaaaggctaa 999481 tacaggcttg cctctttcac cgatcgcgga aatacccaat gcaaatagta ctgtaaagca 999541 gatgatggct agaagatccc cttcgaccaa tgactggaag aagtttgtcg gcacaatatg 999601 gaggaacgtt tccgccactg atttattact ttgttctttt tcagtttcaa catattgact 999661 gatgtccgat ttttgagctt cgtgtatatt aactcctgta cccggatgga agatgtttgc 999721 aagggctagt ccgagaataa tggcaaaagt cgtgatgatc tcgaagtaca gaatcgttct 999781 gaagcctaat ttaccgactt gctttccatt tcctgcaccg gctacaccga tgattaagct 999841 ggagacaaca ataggaatca ctatcatttt gattaagcgt aaaaagagat ccccgattgg 999901 ctgcaggtaa gtaggcaatg ctgggttgcc ataccaaatg acgccaacaa tgacacctag 999961 aataagtcca acgaatattt gtgtggctaa tccaaactta attcttttca tagattacct 1000021 cccaaaaaac aaagtatcaa catatatcat gaatagacat atatttaatc tcactattag 1000081 atcaaattat aatagataag aaatcaattc gtctatagta aattatattt cgaaaataaa 1000141 gaatattcaa tgacattatg ataatcacca gaattatcta aaaacaggtg agctttgacc 1000201 taacctgact attatttcaa aattaagaga tatgtgaaaa aataagaaaa tcccacgcgt 1000261 aaggcgcggg attttcgctc attacaaatc gtttactttt atacagtcat tgcagatatt 1000321 accataacac tcatgctgct cttctatctt ttttccgcat tccgcacact ttttcgaagg 1000381 caggtttcta aaaaattctg tgattttccc cagcataacc aatccctctt tcccctttgt 1000441 agtgatttca ttgtaatata acagattaca aaaatcaata actgttttga tacaatgttt 1000501 aaaacatgct tttttcaaga aaaatgggta tattgaagga ggaccaattt ttttgaaaag 1000561 ataggaggac attatgaaag ttacagttat cggatgctat ggcggttttc cggccgcaaa 1000621 tgaagcgacg tcaggctatt tgtttcagtc aggtgattac tctctgcttg ttgattgcgg 1000681 cagtgccgta ttgtctaagc tgttcggata tgtgccggcg gaaaagctgg atgcggtcgt 1000741 tctgtctcat tatcaccatg accatatcgc tgatatcgga ccgctgcaat ttgccaagca 1000801 agtcggttcg tttctcggca aaggagagca tacgcttccg atttacggac atgatgctga 1000861 tatagaacag tttcaaaagc ttacatataa aacacataca aaagggatcg cctatcagcc 1000921 ggatcagccg ctgactgccg gtccgtttac gatcaccttt ttaaaaacga ttcacccggt 1000981 gacgtgctat gccatgcgga ttactgacgg cagccacact gtcgtttata ctgctgattc 1001041 cagctatcag gattcattta taccgttttc gaaagatgct gatttattga tctcagaatg 1001101 caatttttat gccgatcaag acggaacaag tgcaggccat atgaacagcc tggaagctgg 1001161 gcgcattgca aaagaagccg gagcgggaga actgctgctg acacatttgc cgcattttgg 1001221 cgtgcatgac aaccttcgca aagaagcgaa aaccgttttt aacggagaag tgaatattgc 1001281 gaaatcaggt tttgtgtggg aaggataaag gaggagcacc atgttattta tagacaatca 1001341 aaatatcaat gatccgcgga tcaatcttgc tatcgaggag tactgtgtaa agcatttaga 1001401 ccctgaacag caatatttgc tcttttatgt gaatcaaccg tctattatca ttgggaaaaa 1001461 ccaaaataca atagaagaaa tcaatacaaa atatgttgag gaaaacggga ttatcgtcgt 1001521 ccgccgttta tcaggcgggg gcgctgtgta ccatgatctg gggaacttga acttcagctt 1001581 tattaccaag gatgacgggg acagctttca taactttaaa aaattcactg agccagtgat 1001641 tcaggcgtta catcagcttg gggttgaagc cgaattaagc ggccggaacg acattgtagt 1001701 agatggccgg aaaatatccg gaaacgctca gtttgcaacg aaaggccgta ttttcagcca 1001761 cggcaccctc atgtttgatt cagccattga tcatgttgta tcagcattaa aggtgaaaaa 1001821 ggataaaatt gaatcaaaag gcatcaaatc gatcagaagc cgagtggcaa acatcagtga 1001881 gtttctcgat gataaaatga ccaccgaaga attccgcagc catttgcttc gccatatttt 1001941 taacacaaac gacgttggaa acgtgccgga gtataagctg acggaaaaag attgggagac 1002001 cattcatcaa atttcgaaag agcgctatca gaattgggat tggaactacg gccgctcacc 1002061 aaaatttaac cttaatcatt cgaagcgtta tccggttgga tcgatcgatt tgcacctgga 1002121 agtcaagaaa ggcaaaatcg aggactgcaa aatcttcgga gatttcttcg gtgtcggtga 1002181 tgtatctgaa attgaaaacc tgctggtcgg aaaacaatac gaacgcagcg tcatcgctga 1002241 tgtgctcgaa ggtgtgaatc tcaagcatta ctttgggaac attacgaaag aggatttcct 1002301 tgatctgatt tactaaggca aaacacatcg tttgaaagag cggttgtgtt tttgaaataa 1002361 tggaggcagg agggattcac atgaaagtgt ttttaatcgg agcgaacgga caaatcgggc 1002421 aaagactcgt ctctttattc caagataatc ctgatcattc catcagagcg atggtcagaa 1002481 aagaagaaca gaaagcgtct cttgaagctg ccggtgcaga agctgtgctt gcgaatctgg 1002541 agggcagccc ggaagaaatc gccgctgcgg caaaaggttg tgacgcgatc attttcacag 1002601 ccggttccgg cggcagcaca ggctatgata aaacgctgct ggtggatctt gatggagcgg 1002661 caaaagccat tgaagctgcg gccattgccg gaatcaaacg gtttattatg gtcagcgccc 1002721 tgcaagccca taaccgtgaa aattggaatg aggcactcaa gccttattat gtggccaagc 1002781 attatgctga taaaattctg gaagcgagcg gtttaaccta tacgattatc cgtccgggag 1002841 gccttcgcaa tgagcctgga acgggaactg tttcagcagc gaaggatctg gagcggggat 1002901 ttatttcccg tgatgacgtt gcaaaaacgg tcattgcctc tttagatgag aagaatacgg 1002961 aaaatcgggc ctttgatctg acagaaggag atacgccgat tgccgaagca ttgaagaaac 1003021 tatgacagta ctgacactca gggctttttg ctcttgagtg tttttttctg tttctctata 1003081 atggagaaga aagcttggct tcaataatga atgactattc attcacttaa ggggtgggag 1003141 aatgaatctt gtttcaaaat tggaagaaac agcatctgag aagcccgaca gcatcgcatg 1003201 caggtttaaa gatcacatga tgacgtatca agagctgaat gaatatattc agcgatttgc 1003261 ggacggcctt caggaagccg gtatggagaa aggggaccat ttagctttgc tgcttggcaa 1003321 ttcgcctgat tttatcatcg cgttttttgg cgctttaaaa gctgggatcg tagttgttcc 1003381 catcaatccg ttgtacacgc cgacagaaat tggttatatg ctgacaaatg gcgatgtaaa 1003441 ggcaatcgtg ggcgttagcc agcttttgcc gctttatgag agcatgcatg aatcgctgcc 1003501 aaaggttgag ctcgtcattt tatgccagac gggggaggcc gagccggaag ctgcggaccc 1003561 agaggtcagg atgaaaatga caacgtttgc aaaaatattg cggccgacat ctgccgctaa 1003621 acaaaaccaa gaacctgtac ctgatgatac cgcggttatt ttatatacgt caggaacgac 1003681 tggaaaaccg aaaggcgcga tgctgacaca tcagaatttg tacagcaatg ccaacgatgt 1003741 cgcaggctat ttgggaatgg atgagaggga caatgtggtc tgcgctcttc ccatgtttca 1003801 cgtgttttgt ttaaccgtct gtatgaatgc accgctgatg agcggcgcaa ctgtattgat 1003861 tgagcctcaa ttcagtccgg catctgtttt taagcttgtt aagcagcagc aggcgaccat 1003921 ttttgccggt gtgcctacaa tgtataacta cttgtttcag catgaaaacg gaaagaaaga 1003981 tgatttttct tcgatccggc tgtgcatttc gggaggcgcg tccatgccag tcgcgttgct 1004041 gacggcgttt gaagaaaaat tcggtgttac cattttggaa ggctacgggc tctcggaagc 1004101 atcacccgtc acgtgcttta acccgtttga caggggcaga aagccgggct ccatcgggac 1004161 aagtatctta catgtcgaaa acaaggtcgt agatccgctc ggacgcgagc tgcccgctca 1004221 ccaggtcggc gaattgatcg tgaaaggccc caatgtgatg aagggctatt ataaaatgcc 1004281 gatggaaaca gagcatgcat taaaagacgg gtggctttat acgggggact tggcaagacg 1004341 ggatgaggac ggctattttt acattgttga ccggaaaaaa gacatgatca ttgtaggagg 1004401 atacaatgtg tatccgcggg aggtggagga ggtgctgtac agccatccgg acgtcaagga 1004461 ggcggttgtc atcggcgtgc cggaccccca aagcggggaa gcggtaaagg gatatgtggt 1004521 gccgaaacgc tctggggtaa cagaggagga catcatgcag cactgcgaaa agcatctggc 1004581 aaaatacaag cggcctgccg ccattacgtt tcttgacgat attccgaaaa atgcgacggg 1004641 gaaaatgctc agacgggcac tgagagatat tttgccccaa taaaatgaaa aagcgaagcg 1004701 gttagcttcg ctttttcatt ttcaatcctt tgcttctttt ttaataatat ttagcagcgc 1004761 ctttgtatca tttttgctta atttgtagta tgtgccatcc ttcaaaaaaa cggcttgctg 1004821 gctgccgtca atccatagtc tgaatgagtc ataccggtct ttatgaaact tgattgtccc 1004881 ttcgtaatca ggggctgatg ttttttctgt cttcacctgt tttccctgat tcataatatc 1004941 cagcatatct ttgacgtgct gtcttttttc aatctcgata tcttcctggc cgcttgaaga 1005001 cagtgtgatc aaatccgcgt ctaccgattg atacacatcg cctgatcggc tgtaaagata 1005061 aaaaaatgcg ataaacacaa gaccgattac cacgatggct gccactattt ttttcatttg 1005121 catcactcca aacattgtta gttttcccag cgatcggggt ttccatgctt aaaagggtgg 1005181 aaaagtgcgg aacacagctt ggttctaaga atttgaattt atgattacaa tagaagtaac 1005241 gggttgatgt gaggagtgag gcgttatgcg caagtggatt gcggcagcag gacttgctta 1005301 cgtgctgtac gggctgtttt tttattggta ttttttcctg tcgggtgatt ccgcaatacc 1005361 ggaagccgtg aaagggacgc aggctgatcc ggcttctttc atgaagccgt ctgagttggc 1005421 agtggccgag cagtattcga atgtcaagaa ttttttattt tttatcgggg taccacttga 1005481 ttggtttctg ttttttgttc tgcttgtcag cggtgtttca aagaaaatca agaaatggat 1005541 cgaagcggcc gtgccttttc ggtttttgca gaccgttggt tttgtgtttg tgctttcgct 1005601 gattacaaca ttggtgacgc tgcctttaga ttggataggc tatcaagtat cgcttgacta 1005661 taacatttcc acacagacaa cggccagctg ggctaaggat caggttatca gcttttggat 1005721 cagctttcca atctttacgc tttgcgttct cgttttttat tggctgatca aaaggcatga 1005781 aaaaaaatgg tggttatacg cctggctgtt aacagtgccg ttttcgctgt ttctgttttt 1005841 tattcagccg gtcattatcg atcctttata caatgatttt tatccgctga aaaacaaaga 1005901 gcttgaaagc aaaattttag agctggcaga tgaagccaat attccggctg accatgtata 1005961 tgaagtgaac atgtcagaaa aaacaaatgc gctgaatgcc tatgttacag gaattggggc 1006021 caataaacgg attgtattgt gggatacgac gctgaacaaa cttgacgatt cagaaattct 1006081 gtttattatg ggccacgaaa tgggccatta tgtcatgaag cacgtttaca tcggtctggc 1006141 tggctatttg ctcgtgtcgc tcgccggatt ttatgtcatt gataagcttt acaagcggac 1006201 ggttcgccta acccgcagca tgtttcattt agaagggcgg catgatcttg cggcacttcc 1006261 gctgttattg cttttgtttt ctgttttgag ctttgcggtt acgccttttt ctaatgctgt 1006321 ctcgcgttat caggagaata aggctgacca gtatgggatc gagttgacag agaacagaga 1006381 agccgctgtt aaaacgtttc aggatttggc cgtgacgggg ctgagccagg ttgatcctcc 1006441 ggtgcttgtg aagattttca gaggcagcca tccgtcgatc atggaacgga ttcaacatgc 1006501 ggagaaagaa gagaatgcgc cggaacatca ggatgctgac aaataaaaag aagcaggtat 1006561 ggaggaacct gcttcttttt actattattg tgcagctgct tgtacgttga ttaacccttt 1006621 tccatagtag aaagagtttc caagatatgt tgcagtgctt tctaaacgat cacggacttg 1006681 cgcgtttgtc caagtcgggt gcttagaaag aattaacgct gctgctccgg caacgtgagg 1006741 agtcgccatg gacgttccgt tataagcgcc gtaagtgcct ccaggaagtg tgctttggat 1006801 ggacacgcca ggagccatca catcaagctc agaacctgcg ctggagaatg aagctctttg 1006861 gttgctgctg tttaccgcac ctactgcaat agtagaagga tattttgcag ggtagccgac 1006921 tgtgcttgtg cttccggatg aaccttcgtt tccggctgcg gcagcaacga cgataccgct 1006981 ggaaacggct ttgtcaacga ctgttttcag cgctgtagaa ccagtaggtc cgccaaggct 1007041 catgttgata acatccatat tgttggaaat ggcccactca atgccgttaa taatccagct 1007101 atattggccg cttcctgttg aatcaagcac ttttactgca tataatgatg cgcttggcgc 1007161 tacgcccaga acaccgattg agttattaag agcggcaatc gtaccggcta catgcgtacc 1007221 gtgagaactg ccgtcctggt atgggtttgt ttcagaaggt acgaagcttg ctccgcctct 1007281 gacgtttaag tcaggatgag aagagtcaat tccgctgtcg ataacagcta cttttacgtt 1007341 agagcctgtg tagccttgag agtgaagagc cggcgcttta atttgagaaa tgccataagg 1007401 aacagattgc gcatattcat gtgcaatatg atcttcttcc acatatgcaa cgctcggatc 1007461 ttttttcaat tcttttacag ctttttcatc caatgttgct gcggccgcgt taacatactt 1007521 aaattgcttt tgaacctttc cgcctttttc agaaataaca tcctttttct tggcggaact 1007581 catggcactc attgtctgtt taaatccgac aatgtatttc ttttctgtac tgctttttcc 1007641 ggcagcctgc gcagacatgt tgctgaacgc catcgtaaag attaacgtta acgcaaacaa 1007701 caagctgatc cacaattttt tgcttctcac tctttaccct ctccttttaa aaaaattcag 1007761 agtagactta cttaaaagac tattctgtga atttattgta atagatggaa taatatttta 1007821 gtagacccat ttttttgaga tgattttatc tctatttagg tatatcatct ctcgctattt 1007881 ccgtagagac tcgaaataac tattttcata cagaaaagaa cgaaaataga catgagtaaa 1007941 tgttcattat gctgaaatgt catgcttttt taggttaaat gctcctgagt cccggcaaat 1008001 tcctgtcgaa aaaattcgtt caaatgacct gcgtgtgctt ccgtgagaac aatggatatt 1008061 atcgtgatat tttttcaaag catgatgata aaagtattct gaaaaataaa ctttacagaa 1008121 aagggataga atgaaaaaat tattgagagg gaggaagaaa taagatgaac attcgccaag 1008181 caaagacatc agatgcggcc gccattgcgc cgctgtttaa ccaatatcgg gaattttata 1008241 gacaggcatc cgatttgcaa ggggcagagg cttttttgaa agctcgtttg gaaaatcacg 1008301 agtctgttat tttgatagca gaagaaaatg gagaattcat aggctttacc cagctctatc 1008361 caacgttttc ttctgtgtca atgaaaagga tatacatatt aaatgactta tttgtcgttc 1008421 ctcatgcgcg tacaaaggga gccggcggcc ggctgctttc tgccgcaaag gattatgcag 1008481 ggcaaaacgg ggcaaaatgt ttaacacttc agactgagca ccacaaccgg aaggcaagaa 1008541 gcttgtatga gcaaaacggc tatgaagagg ataccggatt tgtccattat tgtctcaatg 1008601 tgccggcgaa gtgaaaatgg cggcttgatg atttggtttt ttgaacgttc ttcggttacg 1008661 atataaatga aaaggagtgt gccgaatgtc aacgttattt caagccttgc aggcagaaaa 1008721 aaatgccgat gatgtttcag tccatgtgaa aaccatatca acagaggatt tgccgaagga 1008781 tggtgtcctg attaaagttg cttattccgg cattaattac aaagatggtc tggccggaaa 1008841 agcaggaggc aatatcgtca gagagtatcc gcttatttta ggcattgatg ctgcgggtac 1008901 ggtcgtctct tccaatgatc cgcgttttgc ggagggggat gaggtgatcg cgacaagcta 1008961 tgagctcggt gtctcacgtg atggcggatt aagtgaatac gcttcggtgc ctggtgactg 1009021 gctggtgcct ttgccacaga atctttcgtt aaaagaagcg atggtgtacg gaacggcggg 1009081 atttactgcg gcgttatcag tgcatcggct tgaacagaac ggtctgtctc cggaaaaagg 1009141 cagcgtgcta gtcacaggag caaccggcgg tgtcggcgga attgcggtat cgatgctgaa 1009201 caagcggggt tatgatgtgg tggcaagtac cggaaaccgg gaggcggctg attatttgaa 1009261 acagcttggt gcaagcgaag taatcagcag ggaagatgtc tatgacggaa cgcttaaggc 1009321 gctgtccaag cagcaatggc agggagcggt tgatccagtc ggcggaaaac agcttgcctc 1009381 gcttttaagc aaaattcaat acggcggatc tgtcgcagtg agcggcttaa ccggcggagg 1009441 agaagttccg gcaaccgtgt atccttttat tcttcgcgga gtaagcctgc tcggaatcga 1009501 ttcagtatat tgtccgatgg acgtcagagc cgctgtttgg gagcgcatgt cttctgatct 1009561 caagcctgat cagctgctga ccatcgtgga cagggaagta tcattggaag aaacgccggg 1009621 tgcgttaaaa gatattttgc aaaatcgcat tcaaggaaga gtgattgtga agctttaaca 1009681 ggatcagctt gcagagaatg ttatttttct gcaagctttt ttgtggacag gatgatcagc 1009741 tgctgaactg ctgtgtcgcg aaacaagatt ttcctgtaag ccgaactttc tcttctcatt 1009801 ttaaaaataa ttggtgataa tgattctcat tccgtgttat actactcttg gacatcttaa 1009861 ccatagaaac taccaacagg agagactgga acatatgaaa aaaacactga ttattcttac 1009921 agttttactt ctttctgtct taacggctgc ttgctcgtct tcaagcggca atcaaaacag 1009981 taaagaacat aaagtggcgg taacacatga tttagggaag acaaatgtgc ctgagcatcc 1010041 gaagcgggtt gttgttcttg agctaggttt tattgataca ctgcttgatc tcggcattac 1010101 gcctgtcggg gttgccgatg acaacaaagc gaagcagctg atcaacaagg atgtgctgaa 1010161 gaaaattgac ggctacacat ctgtcggcac tcgctcacag ccaagcatgg aaaaaatcgc 1010221 ttcattaaaa cccgatttaa ttattgctga cacgacccgg cataagaagg tgtacgatca 1010281 gctgaaaaaa atagcgccga cgattgcact taataattta aatgctgatt atcaggatac 1010341 aattgacgct tcgcttacga ttgcaaaagc agtcggcaag gagaaggaaa tggagaaaaa 1010401 gctgacggcg catgaagaaa agcttagcga gacaaagcag aaaatcagcg cgaacagcca 1010461 gtccgtgctt ttgatcggaa atacaaatga taccattatg gccagggatg aaaacttctt 1010521 tacatcgaga cttttaacac aggtcggcta ccgatatgca atcagtacgt caggcaatag 1010581 cgattcaagc aatggcggcg actctgtgaa tatgaaaatg acactggagc agctgctgaa 1010641 aacagatccg gatgtgatca tcctgatgac aggaaaaaca gatgacctcg acgccgacgg 1010701 taaacgcccg atcgaaaaga atgtcctttg gaaaaaactg aaggcagtga aaaacgggca 1010761 tgtataccac gtggatcgtg cggtgtggtc tctgcgccgc agtgtagacg gggcgaatgc 1010821 cattttggac gagcttcaaa aagagatgcc ggctgctaag aaataaaaga aaagacaggc 1010881 aaacgcctgt ctttttctta tttgataaag ccggataagt ggctgttgat attatagtct 1010941 tttatccgcc atttttcttc tgcaaattca atgttgctga ggcaggcgtt gacgagacgg 1011001 gtgctttgaa gctccgggtc accgccggat atttctgtca gcagggcgtg aattgccgca 1011061 ccgtgcgcca cgatcagcac cttcttgttt ggatacgcct gattcacttt tgccaaaccg 1011121 cccatcagcc tgtcagtgag ttcttctaag gtttccatat tcggatagat gttatctgga 1011181 tagcgctttg tccgttcctc cagcggcatg ccctccgcgt cgccgtaatc gcgttcctta 1011241 aaatcatcca tctcgactat cggaagatgc agatattcat taataatttc cgcggttctt 1011301 ttcgctcttt tcagcgggct cgtcacaata atatcccaag aaaagtcctt tacatattct 1011361 ccggtttctc ttgcttggcg ttcacctgtt gcgtttagcg ggatatcggt tttgccttgg 1011421 catttttgct gcaggttcca atcggtttct ccatgtctta ctaaacaaac ggctgtcata 1011481 aaatcccctt cctgacttta ttcatatcgc tattatacta aatcgaaagc gtgtgtccta 1011541 tgaaaaagcc tatgcaagaa cttcaaataa taaagccagt ccgattccgc cgccgcttcc 1011601 gatggctgca acagcatatt gacagtctgg ccgtcttttc gcttcataaa acaatctggt 1011661 taccagagct gcacctgatg caccgtacgg atggccaaga gctaaggcgc cgccgcgcac 1011721 attgattttt gaaaagggaa tgccgagttc ttgcgagcag acacaaattt tgacggcaaa 1011781 ggcttcattg atttcaaata aatcgatatc atcaggtgtt acatcgtgtg tatgtaagag 1011841 ctgacgaatc gcgacaaccg gtgccgcggg cggaaagttg gggtgaatgc cgctgacagc 1011901 gctgccgata aaccgaagca caggcttaag tcccagggct gctgcttttt cttcttccat 1011961 taccaaaaga gcggctgctc cgtctgctat gccactgctg ttggctgctg tgactgttcc 1012021 ggagctggtg tcgaaaaccg gctttgcacg gggaataatc gcttctattg gccgcgtttt 1012081 caaaaatgct tcgtccgtct ccaattcccc gagagcaaca acttcttcac ggtaaaatcc 1012141 ttcatcatgc gcgttcctgc tgcgttgatg gctgagaagc gcgtactcat cctgcatgct 1012201 tctgctgatg gaatagcgtg cagccgtata ttctgccgca atgcccatgt ctggatcgcc 1012261 gatcgcatct ggagaaaagc gagcccgttc tgaaaaaggg gattggctgc tgctttctga 1012321 gccgcccgcg atatacatcg tgccggctcc cgcttgaata aggctgcagg catagcgcac 1012381 agcttcaagg ccggagccgc actgtctgtc aattgtcatt ccgggaaccg ataaaggcag 1012441 tccggcttga agggctgaca gtctggccag gttgccgcct ctgccagtag cgtttccgag 1012501 aatgacctcg tcaacttgat cctctagctt tcggctgaga cagcggatga tgggagccgc 1012561 caaatcctcc ggcaggaagg gcttcagcag tccgttttga tttccaaaga tcgttcgttt 1012621 tgcatcaaca ataaccgcat tcatttatac tgtacactct cttccagcca ttttttcact 1012681 ctggaacggg caatttttcc gctgctcgtt tccggcaagc tgtctgcaaa cacccatttt 1012741 ttcggaattt tataggaggc taatttctgt ttacaccagg ctttcagtgt tctggcatta 1012801 gcgtttccaa gaatgacagc tacagcgatt tctccccaat actcgtcggg aatgccaacg 1012861 acagccgcgc tttcaacctc tgggcaggcg agaagcacac gttcaatttc ttctgggaaa 1012921 atatttaatc ctccgtacac gatcatcccg ttttctcttc ctgatatgta tagaaagccc 1012981 tcttcatcaa cgtagcccat atcatctact gtcatccatt catctggtgt gctgccgttc 1013041 acatagccgg aaaacctcat cgggcttttg acaaatattt ttccgatttc tcctggctgg 1013101 cagcgttctc ctccagcgtt gcggatttcg atccggacat tatgaaaagg gcggcccgct 1013161 gaatgcggct tccgtttgct gtcttccggt gaagaaaacg tcacaaaact aagctctgat 1013221 gtgccgtaaa aatcgtacag cttgagatga ggccatgcag cggcaagctt cttcttggat 1013281 tctgccggcc agtctgcgcc ggatgaaatg attttgacgg gactgtcggg aaaaccctca 1013341 atccttgcga gggcgtctgt catcgtcggt acggtataga gaacactgat ggattcacgg 1013401 cacagccatt ccttcgcttt ggcaggagaa aactttttca gcaaacaaac ggttcctccg 1013461 agaaacaaag tgctgacagc cccatatagg aagtgagagg acattaacgc tccgggaatc 1013521 agaaccttat catctgatga aatcgaaaaa tctgtttctg tacaggtaaa gctctccatc 1013581 catgagcggt gagatcgcgt aaaggccttc ggttttcctg tcgagcccga cgtaaatccc 1013641 atataaaaag ggtgctccgg atcaatggta ggcaagggat cagcggctgc ctcagaaata 1013701 tctgccatac agttatccag caatacaaca ggtgtctggc tatctgtcag tttgtttttg 1013761 aaaaaggcta aagtaaccac aagatccgca ttgcttatgg acagccgctc cttacattca 1013821 gccgggctcc agcgtgtgtc gatgggaatg gccgtacatc cagccgctgc ggctccggca 1013881 aacagctgta aaaacgcgag actatttggg agcaggatcg ccacacgatt cggcatgctc 1013941 ggctgtgacc gcagccaatt tgcggtttga gagacaagcc gatcccaatc atggtacgtg 1014001 atttgctccg attcagtctg gatcgctaca cggccgggcg atgtttcggc agtagatgaa 1014061 taggtatgag taattgtcat gtattgtcat cctccttttg taaacatcgt atcagaaaga 1014121 gacaaggctt gagtgatttt tatcgccaga aatgcagata cagccgcttt tatcaaatca 1014181 ccaggcacat atgcaaggct catgaaggcg gcctgtgaca aatcaatatg catgataaaa 1014241 gcttgtaccg gtataccaag cagataaata aagatgatgc cgaatacgat atgagtgaaa 1014301 aagagacgca atactgtcac cttccgcagc ctgttagcgg ctaaactgat cagccatgaa 1014361 gcgaggggat aagcaatcaa aaagcctgcg ctcggtccga aaaacacacc aaaaccgcct 1014421 cgtccgccgg gcaacagcgg cgctccgaag gcgacgagca gcaaaaagac aagctggctt 1014481 aagaaagcag actttggcct gagaatgctg cctgccaaca tgacaccaag cgtttgcaat 1014541 gtaatcggaa cgggtgtaaa ggataagaag agagggggca taaagccgag cactgccatc 1014601 agcgcggtga aaatcgcaat atgcatcatg tcgattaatt tcagcatgtg aaatcctcca 1014661 aaaagtaatc aaatatggtt atacaataaa tgcaggtaat tattatgtca actgattttt 1014721 aatttaagtt tacataatga acgcaaaaaa accggccgta tggcagaccg gtttttgatg 1014781 gttattcttc tgtcaggatg acaagcgaat caacggaagc ggccacatgg gaaacggcgc 1014841 ggctgacttc ctgaagccct ccaagaaagg cttgcagatc gacgtcgatt ttgcctgatt 1014901 gctctttgct gattttcatg ctgtggacga tttcatcgaa taagcggtta atttgcgtca 1014961 ttttttcttt actttcgctg actagctcat tcacgtcttt gatatgcttg gatacaatgt 1015021 tgatttgtgt attcgtattg ttcacaagct cagaaacagt agagacggtt tttttcgtat 1015081 cctcagaaag cttccgcact tcatttgcca cgacagcaaa gcctttgccg tgttctccgg 1015141 cgcgggcgga ttcaatagat gcattgagcg agagaaggtt tgtttgttca gctatgcctg 1015201 tgacgatgcc gaagattttt tcaatttgct gcgcgatttc atccagcttg accatttctt 1015261 tttcgatttg gacaaggctt gtgtcaattt tgttcatctg tttttgctgg acttctagct 1015321 ctttttttcc gccgatcgac ttttcttcaa cagtgctgga tgttacagtg ccggctttgg 1015381 atgcttgaga aatgccttca gatttgtcca caagctcttg aactgatctg cttgtttctg 1015441 aaaacagatt ggcaatcgat ccagaggttt cttgaatttt ctgatgaaga aggtttttct 1015501 tttcttcttg ttcatcacgg gtctggttgt actcgctttg aaacgcttca aggacaagct 1015561 gctgttctaa gttcaagatt tttgttgttg ctttaatggc ttttagcagt tcttgctgat 1015621 ttgtaatgga cgcttcataa atgtcaatca ttgacaaaag gagctcttga aacgcaccca 1015681 tataccattt tggcaaaagg ccgattctta aatggatgga ggcgattcgg ttacgctttt 1015741 caataaattc atcatcgata acgcctgcaa acatttcctg aatatgccgt tttaacgttt 1015801 gttttaagcg gtcaactgag ctgtgatcat taatgatatc catcaatgag ctttcatggt 1015861 caaggttttt ataaaacgca tcgacgatat ttacgatatt ttcttgaatg agtggctgaa 1015921 gctgctctaa cacataaagc tcagcatctc ccaacctgac cattttgagc tgttttttga 1015981 catctgcatg tttgtttgtg agctgaatgc ggtttttttg ttgtccgttt gaatctgaaa 1016041 agtaagctgt ttcttgtttt ctgtcttttt taaataacaa tacaatgatc ccccttggga 1016101 aaaatataat ttttactttt tggcttttta agcctttttc ttttttatcg gccaagggaa 1016161 acatgaatga agctgcagat gaaaaatatt tgaaaaaacg ttcattaaaa tgaacggttt 1016221 aatcgagatc tatttgtttt aatggtttaa tggccggacc ctctacaact tcgccagatg 1016281 gcttaaagcg tgatccgtgg cacggacaat cccacgtatg ctcactgtcg ttccactcga 1016341 cctcgcagcc taaatgggta caagtcgtat caacgagatg gaggcagcct gtctcatcac 1016401 gaaatgctcc cgctcgcctg ccgtttatgg tgacggcttt cccttctcct ggcgaaatgt 1016461 cttcaaattg gacatcaggc ttttcaagct ttccttttat caaatgcttg gcgacatctg 1016521 cattgtagga aatcactttc tgcaacccgg gattcagatg gaaacgggac ggcgtgaaaa 1016581 tgctttcgta tgggttttct tttttctcca caaggtctga caataaagtg gctgcgactg 1016641 ctgaggacgt catgccccat tttttgaacc cggtcgctac tagaatattg tcctcatttt 1016701 ccgacatcgg cccgataaac gggattttgt cgatcgtcac tagatcttgg gtggaccaat 1016761 aatatggaat gctttcgatg ccgatggtgc tttcggccag ttgtctcagt gtttcataat 1016821 gtgtagacat ggcttttccc tggcctgttt tatggcttac tccgctgaag agaatcagct 1016881 tttcaccgtt tacaaccgta tagcggagcg ccactgacgg ctgatcgata ctcaaataca 1016941 tgccctcggg atactcgatc ttcggcttga tggcaaggac ataagatctg tcggagtaca 1017001 ttctcgcagc atataatccg cctccgtcat aaaaagggaa gtgggaacag catatgataa 1017061 agcggctctt aatggcgtgc cggctttttg ttaccacttc gggcctttcg ccttttttga 1017121 tatcaagcgc aacggtctct tcataaattc ggccgccttt ttgaacaatt tgctccagaa 1017181 gcgcttttaa gtattgaagc ggatgaaatt gagcttgatt cttcatgaca agcgccagct 1017241 tagaacctaa gggaattgga agatccttga taaggtctct ttcaattccg agctttgtgt 1017301 atgcctcatg ctcggtgtgg attttttgaa cagcgttttc atttgccgta taaagatatg 1017361 cgtcttgctc gatccattca caatcaattt gatgttcatc cacaatgcct tttatgtaat 1017421 caattgcgtt ttggtttgct tcataataaa gcctcgcatg gtttaatccg aaatggcgga 1017481 taaattcgtc gtatatcatg tcatgctgtg cggtaacttt agcagttgta tgcgcagtgg 1017541 ttccgttaag aacctgattt gcttcaatca aaacgacacg gaagcctctc ttcgtaagtt 1017601 catatgccgt tgtgattccc gtaatcccgc ctccgataat ggtgacgtca cattcagtgt 1017661 cctcttgaag cgcaggaaaa gaaggcaggt cagttgatgt tttccagtat gtttcaggtg 1017721 cttcctttgc aaaatgttga ttagccaagc cgttatacct ccaatcagat ttattcttaa 1017781 tttttccata ttctatcttt tcatacatag gaagcaggca ttgttcataa cataataagg 1017841 ttgaaaagga gtgatttcat tggcgaatca aaaaaagaaa acattaccgc ctcagcacca 1017901 gaaccagcag cctggttttg aatatctgat ggacccgcgt ccggtttttg ataagccgaa 1017961 gaaagcgaaa aaattagagg gcaaaaccgc tattattact ggaggagaca gcgggattgg 1018021 acgcgctgtc tcggtgttat tcgcaaaaga aggggctaat gtggtcattg tgtatttgaa 1018081 tgaacatcag gacgccgagg aaacaaagca gtatgtagaa aaggaagggg taaaatgcct 1018141 gctgattgca ggagatgtcg gggatgaagc gttttgcaat gatgtggtcg ggcaggcaag 1018201 ccaagtgttt ccatccattg atatattggt taacaatgca gctgagcagc atgtccagcc 1018261 cagcattgaa aaaatcacca gccaccagct gatcagaacc ttccaaacaa acattttttc 1018321 catgttttac ttaacaaagg cagtgctgcc tcatttaaaa aaagggagct ctattattaa 1018381 taccgcttca attaccgcct ataaaggcaa taaaacgctg atcgattatt cagcgacaaa 1018441 aggcgcgatc gttacgttta caaggtccct ttcccagtcg cttgttcagc agggcatacg 1018501 ggtcaatgca gtggcaccgg gtcccatttg gacaccgctt atcccggcca gctttgccgc 1018561 aaaagacgtg gaagtgtttg gttcagacgt gccgatggaa cgcccggggc agccggtcga 1018621 agtggcgcca agctatctat accttgccag cgacgattcc acatacgtca cagggcagac 1018681 gattcacgtc aatggcggaa caattgtgaa cggataataa aaagccaatc cttgaaggat 1018741 tggcttattc gctctgcttg agcgctgcat attctttaga gagcgtaaga aacgcatctt 1018801 tatctttttc gtccaaggct ttgttaattt ggtccgtcag catggcaagc cgacggttat 1018861 acaaggattc atcgagcacc atttgaatgt aaatatccgt cattgtgaca tcgaattctt 1018921 ttgttttttg cgtgttgcgg gacttcatga gctcagtgta cgattttttc tctttcataa 1018981 agaatccccc caatgccttt tttatagtat atggataacg gtcgaaaaaa tcaataaatt 1019041 tttataattt ttagacaact aatacttggc aatctatcga catatcctgc aaaatgccgt 1019101 aaaccggcaa gtcttatgaa agtaaaatcg gtttattact agtcatttag taccattaaa 1019161 tatcattaaa agatgatttt atcttaaatg ttaaaaaaac ctgtcgtttt acaaaaacag 1019221 atgatagatt attagtataa attttgcaga aaaaggatgg aggccataat atgagtcaga 1019281 aaacagacgc acctttagaa tcgtatgaag tgaacggcgc aacaattgcc gtgctgccag 1019341 aagaaataga cggcaaaatc tgttccaaaa ttattgaaaa agattgcgtg ttttatgtaa 1019401 acatgaagcc gctgcaaatt gtcgacagaa gctgccgatt ttttggatca agctatgcgg 1019461 gaagaaaagc aggaacttat gaagtgacaa aaatttcaca caagccgccg atcatggtgg 1019521 acccttcgaa ccaaatcttt ttattcccta cactttcttc gacaagaccc caatgcggct 1019581 ggatttccca tgtgcatgta aaagaattca aagcgactga attcgacgat acggaagtga 1019641 cgttttccaa tgggaaaacg atggagctgc cgatctctta taattcgttc gagaaccagg 1019701 tataccgaac agcgtggctc agaaccaaat tccaagacag aatcgaccac cgcgtgccga 1019761 aaagacagga atttatgctg tacccgaaag aagagcggac gaagatgatt tatgatttta 1019821 ttttgcgtga gctcggggaa cggtattaga aaaataggaa ggagctgacc gaacagggca 1019881 gctcctttca taaagctatg ccgtcggaat tcctccggtg atgccatata cctgagatgt 1019941 cacatagctt gaattctctg aagctagaaa tacataaaca tcggccaatt ccactggctg 1020001 cccagcgcga tttaatggag ctggcggcgt gccttgtccg aatttcggga tgttttccgt 1020061 cggctgtccg ccggaaattt gcagcggtgt ccaaattggt ccgggcgcaa ctgaatttac 1020121 tctgatgcct ttggaagcaa gctgttttcc cagtccgacg gtaaagccga taatggcgtt 1020181 tttcgttgct gcgtaatcta acagcatcgg gcttggatta tagccttcaa ctgaggtagt 1020241 tgtgataatt gaagctccct ccggcaaata cggaagcgcc gcttttacaa cccagtaaag 1020301 ggaaaagacg ttcacttcaa atgttttata gatttgttca gtaggcagat cttcgatgtt 1020361 ttcgaccgct tgctgtttgc ctgcaacgag cgctagcaca tcaagtccgc cgagttcgtg 1020421 atgcgactgt ttgactagat cttggcaaaa ggattcgtcg ctcaagtctc cggggatcag 1020481 cactgctttt cggccttctg cttcaatcag ctcttttacc tcttcagcat ctggctgttc 1020541 ctcgggcaag tagttaatag ccacatcggc accttctctg gcgtaagcaa ttgcggcagc 1020601 gcggccgata ccggaatcgc cgcccgtgac aagcgctttt cgacccgtta gtttacctga 1020661 tcctttgtag cttttttctc cgcaatcagg gacaggcttc atgttctttt gcaggcctgg 1020721 cggttcttga tattgttcgg gaaattcatc atgaaaaaat gcttttatag gattcgtaag 1020781 atttgaatca gacatcagca acgctccttt tctgtttggt gtacattcgt atgtgtaccc 1020841 ctgagcataa gcagaaaaac atgttttggc agtttgaata gtgaaggaaa aagaaaacaa 1020901 gaaaaaacaa agccttcttc catatttatc ttgtcaaata agactatatg aattatgata 1020961 aattcgagct ataaatcaac taaatattgg gtgttgggag agtgaatcgt catgaaaaaa 1021021 gcggcggcgg ttttgctgtc actcggtctc gttttcggtt tttcatacgg agctggccat 1021081 gtggcggaag ccaaaacaaa ggtgaaggtc tataagaact gcaaggagct aaacaaagta 1021141 tacaaaggcg gagtggcccg cacatcgaag gtgaaaaaca aaggcggaaa aacgaagtac 1021201 aagccttacg tttctaaggc actttacgat gccaataaaa acaaagaccg cgataaagat 1021261 cttatcgcct gtgaacggta aataagaaaa agcaatctgg tgtccagatt gcttttttta 1021321 tgcttaggcc gcctgatcgg ccgcagcgct tttcgccttc cttgtcataa ggctgactgc 1021381 catcatgacc gtgatattca aaagcagggc gacgatgccg acattcaagt cttttgcggc 1021441 ttgcggcaga gccggaaata aagtgccgat cgtcgtttcc gtcattgtaa tataagtaac 1021501 tgctccgaca cctgcaataa tgccggcgaa agctccttgc tttgtcacca tattatgctt 1021561 gagcaggctg aacaaaaggg cggggaatag ctgtgtgaca aggctgtagc ccatcaaaag 1021621 cagcgtaacg atggtattcc cgcctttgaa ggtaaaatac accgaaatca gcgcaatcac 1021681 cggcactaaa aacttagcaa gcgccgatac ttgctgttct gtcgtgcggg gcgcgattac 1021741 cttgtacaca ttttttgcaa acagtgtgga ggcggacatt aagatcatag accctggcac 1021801 aagtgctgtc agcagtccgg cagcaccgat aattccgaca aaccaagggt caaatgcttg 1021861 cagagacagt ctcaaaagcg acaaatcccc gtctgcgcca ttcagatctg gaacttgcag 1021921 gatagccgca aagccgacga aaaggacgaa gagcaggacc agctggtaca aaggcatgat 1021981 gatggcgttt ttacgaaaca cttttgggtt ttcggctgaa tacgaagcgg aaaacgtgtg 1022041 aggccacatg taaaaaccaa gcgctgtcaa gagtacggtt gaactgaacc aggccacact 1022101 ttgtcccgat tcggggagcg taagaaagcc aggctttgcc gtttcaatct gctgaaacat 1022161 gtcttgaaat ccgccgtagt aatgaattgg caaatacaca cctaaaaaca gaacgacaac 1022221 cagaatcatg atgtccttca caaccgatat ccaggcagac ccgtgaatgc ctgaaaccat 1022281 aacataaacc gtgatggaaa cagcgccgat ccagatggca gcggtcgggg tgattttgcc 1022341 gtacgaggtt tccgatacaa tcagcccgag gcctttcagc tgcagtacaa gatagggaat 1022401 gagtgcggcg atgccgacca gtgaaacgag aatgccaagc agcggactgt tgtatttttt 1022461 tgtgaaaaaa tcagactgcg acatcagttt atgctgtttc gcgtacgtcc aaactgctgg 1022521 aagaagccag taagaaagga tgtaggccag acatccgtag gcgatgatat aaaaggctgg 1022581 accgcctttt ccgtaggccc agccgctgcc gccgagaaac gtaaaagtag tataaatttc 1022641 gcctgccatc aaaaggaaga cgaaaacagt tccgaagccg cgccctccga ccgtccactg 1022701 ctccaggttc atgtcttttc ctttttgggc gcgtataccg agaaaaatac tcaagagcag 1022761 gacaccgaag atgatgatga gagctgcatt cattctgctt cctccttttt attttccttg 1022821 tcgaggacat acacaatcgc catcagcgca gaggtcaaaa gagcccacat cacaatatag 1022881 gcaagaataa acggcatgcc gaacacatag ggggtcacct tatttgcaaa agggatgccg 1022941 agtaagattc cgataaaggg taaagcggca agaacgtgaa tcagtttcat agaatcctcc 1023001 ttctatttag gattgaggtg tacaagccta agcgtactga aaatgatgtc gcagatatcg 1023061 cagcacatgt cattttttgg agtgaaaggc tgtggttcga attataaata aatttatttt 1023121 gtttgtatag tgtgaattgt ctgaaattaa tgctctgaat cgcccgaaga gggaacgggc 1023181 agtatgattc aaaaggctca gagtctgtct ggggcaaata gatagtatgt taataattcg 1023241 ctgacctgct cacggattcg cggattaaaa tagcgatggt tttcttcata accgtcgatg 1023301 acaaatgtat agagtgtaaa ggcctcatcg cgttccgtct cgcggattgc aatttttctt 1023361 ttcctcagtt cttttctgac ctccatcaaa tccttttgtg ctatttttaa tgattcgctg 1023421 ataagctgtt tataaggatg cttcaatttt aatgtgcttt cttcaattcc ggcgagatca 1023481 cggttaaaaa tcgtaatggc catgggcaaa aagagagccc gttcaattaa atcgtatatt 1023541 tcctcctgca gatttggcat attgactcct tctttctaag ggaacgtttg ttctatttgt 1023601 attctatatc ggctggtgaa atgtttcaag acagaaaaaa tcaccaaaac tttttagttt 1023661 tctgctgata atgtgtagaa taaggataga caaacccggt aaggagtata aatgttggag 1023721 cattttttat cctatttgac acaagaacat ttaactgaat tatttcaaag ctatagggct 1023781 ttcggtccgc tcattgctgt gctgctgcct ttaattgaag catttctccc gtttttgccg 1023841 ctgatcgtgt ttgtggtggc gaatacgaac tcgtttggct tgtgggaagg attcatccta 1023901 tcctgggcgg gatcaactgc tggttccatt ctcgtctttt tgattgtccg tcaatacgga 1023961 cagagaaaat tgcttggatt tatccgcagt catccgtctg tcagaaagct gatgttatgg 1024021 gtggaaagac acggcttcgg tcccatgttt cttctgcttt gttttccatt tacaccgtca 1024081 gccgcggtga atgttgttgc cggtttgtca aggatcggaa cgcggccgtt tattttggcg 1024141 gcagcctcgg ggaagcttgt catgattttt atgatcagct tcatcggata tgatctgcac 1024201 gcgctgatta cacagccgat tcgaacggtc atcgccgtat tggtgatcac tgtcttatgg 1024261 tatgtcggca aaaaggtgga gcggtatctg catgtaagag ccagtcagcg tgagcatgat 1024321 ggagggagac agtaacatga aaaaacggtt ttggtttctt gccggtgtag tgtccgttgt 1024381 tctcgccatt caggttaaaa atgctgtctt tattgattac aaggtagaag gcgtcagtat 1024441 gaacccgacc ttccaggaag gaaacgaatt gttggtcaat aaattttcgc atcgatttaa 1024501 aaccatccat cgttttgaca tcgtcctttt taaaggccct gatcataaag tgctgattaa 1024561 acgggtaatc ggcttgcccg gtgaaacgat caaatataaa gatgatcagc tgtatgtgaa 1024621 cggaaagcag gttgctgagc catttttgaa gcatttgaaa tctgtttctg ccggcagcca 1024681 tgtaacgggt gatttttctt tgaaagatgt gacgggaaca agcaaggtgc cgaaaggaaa 1024741 atattttgtc gttggagata atcgcatata cagcttcgac agccggcatt ttggtccgat 1024801 aagagaaaaa aatattgtcg gtgtgatttc tgatgccgaa taaaaagacg ctaattgaag 1024861 aggcgtcttt ttgtatgccg tttggaaaaa tgtgttgaag aaaaatttgt aaggagctat 1024921 aatcaaaatt gttacctgtg taacaaaatt tatatatttt tttgactgga gggccgtttt 1024981 tattggtttt tgttcgtttt tcatgaaaca aaaggagtgg tgaatgatga tgaaatatga 1025041 agcagtgatt ataggaggag ggccggttgg atttatgctg gcttctgagc ttgcaatagc 1025101 cggagtggga acatgtgtga ttgaacggct tgaaaaacct gttccgcatt ccaaggcgtt 1025161 gacgctgcac ccccgaacgc tggagcttct tgagatgaga gggattttag agcggttcgt 1025221 atccaaggga agcaagatac ctaccggaca tttttcaatg ctggataccc gtctggattt 1025281 ttcaggcttg gatacgagct gtccttacac gcttttgctc ccgcagtcca aaacagaaaa 1025341 gcttcttgaa gatcatgcac gaagcctggg aacagaggtg tttcggggtg ccgaggcgct 1025401 ggcggttacg caaaacgggg aagcggtcca aacaattttt aaggatcggg acggcagtgt 1025461 acggacgatc acaagcaagt ttgccgttgg ggcagatggc gccgggagta ccgtccggaa 1025521 acaggcgaaa attgagtttc cgggaacaga cagcactgtc accgctgcgc ttggggatgt 1025581 ggtgctcctt tctccgccgc cgtcaggtgt gctgtccctt tgcacaaaag agggcggtgt 1025641 tatgattgtt ccgttatctc cagaccgata ccgtgtcgtt gtgatcagcc cttatcgcac 1025701 acaaacgccg aaagatgtgc ctgtgactga ggaagagctg aaagctgacc tcctgcgaat 1025761 ttgcggaact gacttcggtt taaccgaccc ttcgtggatg tcgcggtttg ggaacgccgc 1025821 gcgccaagcg aaacggtatc gggacggcag aatctttctt gcgggtgatg ccgcgcatat 1025881 tcattttccg gcgggcgggc aaggactgaa tgtcggcctt caggatgcaa tgaacctcgg 1025941 gtggaaactg gcggcggcca tcaaaggctc tgcgccttct tggcttttgg acagctacca 1026001 tgatgagcgg catccggcag cggaagggct cctcagaaac acggaggcac agacaaagct 1026061 gatcgatttc actcaagcag gcctccattt gcgaagcatg atgtcggagc tgctggcctt 1026121 ccctgatgtg aatcgatatg tagcggggca aatttctgcg ctcgatgtca gatatgaagc 1026181 tgatcgtacc atgccgccga atcgtttgaa cggggcaagg ctccctgaca tgaagctgat 1026241 tctttccgac ggcaattcgg aacggctgta cagctttctc caaaacggga cattcgtttt 1026301 gctgtcattg aggcaggaag ctgatgatca tatcgaagta aaaggcttac gtacggtaac 1026361 cgcctcgctt gcagaaccga atgaaaagtt gcggaatgtg cataccatat tgattcgtcc 1026421 cgatggacat gtagcctggg cggtggatgc atcagcgccc gattgttccg aggtgattca 1026481 aaaagggatc agccgctggt tttccgtcac cagccgagta taattcaatt cgattgtttc 1026541 atctgtaaca aaacggtatg atagaagaaa caatcgaatg aaaaaggatg gaaaacccga 1026601 tgaacacaga tcatacgaaa cgcaatcttt ttgaattgta tgcggagctc attcatcagc 1026661 aggagaaatg ggaggggctt attaaagcct ttttatctga cgaattgagg aagctggatg 1026721 tagagcacgg gagtaaatct caattgacga tgacagaaat tcatgttcta tcctgtgtcg 1026781 gggacaatga accaattaat gtcacgtcga tagcagaaaa aatgaatacg acaaaagcga 1026841 ctgtatcacg catcagcaca aaattgctcg gcgcaggctt ccttcacaga acacagctca 1026901 gcgataataa aaaggaggtc tacttccgat tgacgcctgc tggaaaaaag ctgcacagtt 1026961 tgcacaaata ttatcatcag aaggctgaac agcgttttct gtcatttttt gaccgctata 1027021 ccgaggaaga gattcttttt gcggaacggc tgtttcggga tctggtgaca aaatggtatc 1027081 cgtcgtcaga agaaattgaa ggggggcttc ctagcatttt taaataaaaa acacgcactg 1027141 cggtgcgtgt ttttcgcttt gcggccgcct cgagaattct ttcatttcac cctctggcag 1027201 cactcacttc aaatctgatc cattaacaac gaaatatccg cttatatttc ctcatctcga 1027261 tggtttgcga attaaaagtt cttgaaccct tttttcaact aggcactact gccgctgatt 1027321 gagctctttt tgtctttttt ttcaccatga agatggtgaa gcaggcgata aaacggcggc 1027381 agcagggcaa taaccagaat gacgcgaatg acctgaaccg caacgacaaa ggtggaatca 1027441 gcatgtaagg taactgacgt cgtcgccatc tctgcaatcc cgccgggcgc aaatgccaga 1027501 acagaagtga tgagcgaaat tcctgtcagc tcggaaacga tcacggcgct caaaaacatt 1027561 gctgcgatta aaccgacgga cgagacaaac ccgacgatga taatacgggt gacgccggca 1027621 aacatgcttt tgtacatctt agagccgatc gttgccccga gaaatacttg tgatacatgg 1027681 ttagcttgtg acaaccacca tgccgtcatg tcgtgccctg tcaccgcagc tccgccaaca 1027741 tgtacaattg ctacaccgag catgctgccg agcagccatg gagctggaaa ttttaaaaat 1027801 ttcgcagctt tgcaagctcc ccaggcagcg agaataagaa tgacggtcca caaaacggga 1027861 gcgagcctaa aatctgtcgt tgcagaagaa atcgtctctg ctgcggcact tgcggtacga 1027921 tcttgttttg tatagatcag aatgactaaa aacggaatgg aaagcaccac gagcagcaca 1027981 cgcatcattt gaacgaggct gactatagcg gtattggcgc ctacttcctg tgcgatgctc 1028041 ggcatggcgg aaagtccgcc gggagcggtg ccgacaaagc tagtcatcat atccgttttg 1028101 ctgaaacgcc aaagcacata tcctgacagc atggccagca ggatagacaa tatcagcata 1028161 acgccgactg aaaaccaatg gtctttgaga acagagagaa cggataaatt cagcttttgg 1028221 cccaattcga tgccgaggat catctgcccg agggcgagcc atcgtcggtt aattcctttt 1028281 tggtctggtg ccatcatcag ccatgccggc cgtatcatgg cgaggcagca ggcgacaatc 1028341 agtgttccga tcatccatcc aattgatatt ccggttaatg aaagaataaa ccccccggct 1028401 gcactgattg cgataaacca tagatctttg aggagatttt cgtctttctt caatgtaaaa 1028461 cccttcttcc tttttcacgt aacactccaa ttgttcacgt agtgaatgta tttattacta 1028521 tagtatattt ttgttgataa agaaattatg aattattttc tataagcgat tcacttttct 1028581 tatgaccttg tgttcgagct tttctattgt gtaagtcaga gataaacccg ctgtcagcag 1028641 acacacggca agagcgtaaa aaatcacttc tccgccaaat gatgtcagga tcagcccgcc 1028701 tgccagcggt ccgattgagc gggatatatc ccaatgcaga ccatagacag cataaaaccg 1028761 gcccagcaaa tgaggcggcg ccaatttcga tatgaaggtc tggatgtggg ttagcccgat 1028821 gctttcacca accgtcatca ccgctgccgt cactaaaagc attgtcagag aggttgagca 1028881 tgcaaagccg gctgccgcaa gggagtagca aatataagta atgaagagga tcgttttcat 1028941 tgaaagcttt tcggtccctt tgacaagagg tacttggaga acacagctga ataaagcttt 1029001 tgctgctgaa tagatggtca gcatggacag ataatcagaa aacatgtttt tgctgaacag 1029061 cctgtatgtt gtttctgttt gtgcatataa catgctgatg gggagagaaa gcagcaaaag 1029121 aagcaggaca ggcctgtata ttgtaaagct cgcggacatt ttcggggtaa cagctgggtg 1029181 tagcggcttt gtctcaggca gtttcagtgc agcgatcaga aagtagataa acaatgctgc 1029241 agcatctaat gcgaatatcc acacggggtt atgattgtac agcagcatcc ccactagcgg 1029301 tcctgccgtc agacccgtcg aatagatcgc attgatgacc gcaaacactt ccgaacgtct 1029361 gctttccggc gtgctttcag cgatttgggc gcgggaagcg ggaatgtaca acgatcttcc 1029421 gatgccattc atgacataga gaatagcgaa aacatacgca tgctcagcaa atacaaaccc 1029481 tgtcattgcc gctgattgaa gaagcaatgc ggtcaaaatc gctgtgcgcc gcccaagccg 1029541 atccgtcacc cgtcctgcag cgagcgtcag gaaaatatca gcaaatggct gaaggctgat 1029601 gatcagcatt ggcatcatga tactgccgtt taattgttca tgcagataca gcaccataaa 1029661 aggtcccatc attgcacctg tcaggcttgt cagcaattcg ccgaaaaagc ggagccgaac 1029721 gggagcggta tatctcgatt ttatagagtg aaaactggtc aacatgtgat cgccgccttt 1029781 cgctgtttga tatagtagta gtgtatagaa ggggcggcgg cccaaaaagt gaagaaaaga 1029841 agagataaaa gttccccttt tgtcgggagg tgcggggatt gaagctgata gagcactacg 1029901 tggcgcttgt aaaaacaggc tgcgccgagt atgggcaaat gaacgaaatg acgctcactg 1029961 agattgccga ctgtttattt tgtacagaaa gaaatgcaaa gctcatttta cataagctgg 1030021 agaacagcaa ttggattatc cgggaaagcg gggcggggcg cggccgcaaa tctaaaatcg 1030081 cgtttcttcg gaggcctgag gaactgcttc ttcaaactgc aaaggaatat accatgtcag 1030141 gaaagcttaa aaaggcaaag gagctgcttc agcagtatca gtccgcgttt ccagggcttc 1030201 aaaacgaata taacatgtgg ctatcagagg tattcggatt tgtgacggag acaggcgaga 1030261 atggggcgaa ggatgtcctg cggctgttca tcacgcctga atctgtcagc agtttggatc 1030321 catgccaaat atttttgcgg tctgagggcc atttcgtcaa acagatattt gatacactct 1030381 tcacgtttga ttcggatatg caggagccga agcctcattt ggttcatgga tgggaagagg 1030441 tcggaaaaaa acaatggaga ttttttcttc gaaaaggtgt gttatttcat aatggacagc 1030501 cgctgacatc gcgggacgtt gcgtttacat ttcagcgctt tttggaactg gctgacaacc 1030561 cgtataaatg gcttctgcac ggagtgaaac aagtcttaga aaagggccct tattgtgtgg 1030621 agctcatact cgataagccg aatgcgcttt tgccgtatgc tctttgtgat gaacggctgt 1030681 ccatactgcc ggcagaacag ggcggcggga aaaatggaac agggcctttt cagatgaatc 1030741 agcaacatag cgggatgctt gtgcttgaag ccaatgagcg ctacttcaag ggacgcccct 1030801 atttggatcg cgttgagttt gtgttttctg agcaagccgg agagatgaac ggttttacca 1030861 ttcaagaaaa acaaacatgt cctgagcagc aaactgtctt tgatgagcgg catgttcagt 1030921 atttgtcgct taatctgaaa aagaaggggc ctcttcagca ccgaagcttt agaaaagcgc 1030981 tccggctgct gatttcctct gaacggctcg ttcgtgaagc gggagggcac cgaagaattc 1031041 cggttacgtc ctttttgcat ccgagtcctt ttgagtggga gggcgtttcg ccatctgaat 1031101 tgttgaaaaa aagcggatac gagggcgaaa caatcgtgct ttataccttt tcggaaacgg 1031161 atcatcgtga ggacgccgaa tggattcaaa atatttgcgc ccagcacggt atcaggctta 1031221 cacttcaatt ctgtgatgct gctgatctgc gacggccgga aatcgtgcag atggcggata 1031281 tcattcatga cagtgcgacg ttttatcaag acagcgagtt tggttttctg catttgctgc 1031341 tgtcggagaa cagtttcttg tatcagcatc tatctgaaaa gctgacacag atttgctcag 1031401 gaatgacaga gcggatgttt tccatgcctg accgctgttc gagaatcaac atcctgcgtg 1031461 acattgaccg gcagatgata caggagctga acgcgatccc gctgtatcaa aatgtgctcc 1031521 aggtgacatc aagtaaaaat gtaaaaggcc tggtgcttga tgaagaggga tggattgatt 1031581 tgtactccgt atggctgtcc aaataaaaag agggttcttt tttgaaccct cttttttacg 1031641 ctgccatgct gcggcattgt tcagcacagg tgaagcaggc tttcgcacat gcttggcaat 1031701 gatcatgatc gtgctttccg cattcagtgc cgcatgcttc acaaatatcg gcgcaaagtg 1031761 cacaaatttc tttcataaac gggctgtccg tttgcatggc tttgaccgcc agcgcgcaaa 1031821 tatccgcgca ttccctgtca agccggatgc atccgctgag atgatgctgc acgctttctt 1031881 ccaagcattt agtgaaacaa tgattgcaag ccttcatgca atcgatgcaa gcctcaatac 1031941 aagcctcaga atattgctcc atggttgatt ccccctgtat gacagtatat ggttttatgt 1032001 ttcacggctg catttgaaaa aaacagggga gtgtgttttt agctaagggg atatgtacat 1032061 ataccctgaa tgggtatatc taacgttcca tcagatagta taggaaccag acagcgtgat 1032121 tttgttcatc acgtgctgcg cgcgtaaaga cgcctttcgc ttttaagttt gacgtttcct 1032181 cggccgcacg caagtaaaag tcgacggttt cttgttcatc tttaaaagcg gcgtccagtc 1032241 ctcttgtgaa attgtccggg cattcttccg tttgtttcgg catgatgtgt ttgccggtaa 1032301 ttgaaccata cagtgtggaa aattcacgga ggtggcgaat ctcgtcacgc ctgatttctt 1032361 caatctgttt tctgacctca tcgctgtggg cgagttcggc aagcttgcgg tagcattgaa 1032421 tagcactgaa ttctccgttg atggccttct gcaaattccg aatcaaaaca ggatcttccc 1032481 ggtatggcac cggataggga tagtagctgt aatgcaaggg gattcaactc cattcttagg 1032541 aattgggctt ctgtaaaagt atatgttggg cagggagaga tgtgcggaga taatcagctt 1032601 tttatatgtg aaaaggccgt ttttaccaat agatcagatt ggtcattttc gtcaacattc 1032661 gataaaatat agagagataa aaagagaggg gtcttctaat ttgggagcag agtttttagt 1032721 aggcaggtcc gggagtggaa aaacgaagct gatcatcaac agcattcagg atgaattgcg 1032781 ccgggctcca ttcgggaagc cgatcatttt tctagtcccg gatcaaatga cgtttttaat 1032841 ggaatacgag cttgctaaaa cgccagatat gggcgggatg atacgcgctc aagtgttcag 1032901 tttttcacga ttggcctggc gcgtcctcca gcatacggga ggaatgagca ggccgtttct 1032961 gacgagcacc ggcgtacaaa tgctcctgcg gaagctcatt gaggagcata aacaggagtt 1033021 caaagtctat caaaaagcga gtgacaaaag cgggtttacc gcacaggttg agcggatgct 1033081 gacagagttt aagcgctatt gtctggaacc ggaggatatc cgccggatgg cggaaagcgg 1033141 aacggcttcc gagtatcgcg gagaacgtgt tttatctgaa aagctccatg acttatcaat 1033201 tctgtatcag caaatggaaa aaagcctcgc agatcaatat cttcactctg aggattattt 1033261 gacattgctg gcagagcata tcccgcttgc ggaagatata aaaggcgccc atatctatgt 1033321 ggatggcttt tatcagttta ccccgcagga attcagggtg ttggagcagc ttatggttca 1033381 tgcggagcat atcacgtttt cgctcacagc ggacaagccg tcatatgagc gggagccgca 1033441 tgaactggaa ttgttcagaa tgacggggaa aacctattac cgcctgcatc agaaggcgaa 1033501 ggaactgaat ttggacatta cgtataaaga gctgagcggg actgagcggc atacaaagac 1033561 gccggaattg gcgcatctag aggcacagta tgaagcgcgt ccggccattc catacgcaga 1033621 aaaacaagaa gcccttactg tgatgcaggc cgcaaacaga cgagctgagc tggaaggcat 1033681 tgctcgggaa attcacgccc tagtcagaga gaagggatat cgctataagg atgtagcaat 1033741 tcttgcgcgc cagccggaag actacaagga tatggtgaag gaagttttcg cagattacga 1033801 gattccttat ttcattgacg gaaaagcatc tatgctgaac catccgttaa ttgaatttat 1033861 ccggtcgagc cttgatgttc tgaaagggaa ttggcgttat gaagcggtgt ttcgctgcgt 1033921 gaaaaccgaa ctgctattcc cgctcaatga accgaaggcc aaagtgagag aacaggtcga 1033981 tcagctcgaa aattactgta tcgcctatgg tattaaaggc gaccgctgga caaagggcga 1034041 tcggttccaa tacaggcgtt ttgtgtcatt ggatgatgat tttgcgcaga ctgatcagga 1034101 aatcgaaatg gaaaacatgt tgaatgacac ccgcgattgg attgttccgc cgctttttca 1034161 gcttcaaaaa cgcatgaaaa aagcgaagac ggttcaagag aaggcggagg cgctctatcg 1034221 ttatttagaa gagacggatg tgccgctgaa gctggatcag gaaaggcagc gtgctgagga 1034281 tgacggcaga atcattgaag cgcagcagca tcagcaggcg tgggacgcag tcattcagct 1034341 gcttgaggag tttgttgaaa tgatgggaga tgatgagatt tctcttgatt tgtttcagca 1034401 aatgatagaa gccggcgcgg agtcgcttac attttctcta attccgcctg cgcttgacca 1034461 ggtgtttgtc ggcaatatgg atttgtccag aatgtatggc acctcctgca cctttgtgct 1034521 cggggcaaac gacggcgttc tgccggcacg ccctgatgaa aacggggtcc tgtcggatga 1034581 tgaccgggaa tggctgaaaa cgattggggt tgagctatcc tcaggcggac gagagcgttt 1034641 gcttgatgag cacttcctca tctacatggc gttttcaagt ccgtctgacc ggctttacgt 1034701 atcgtatccg attgctgatg cggaaggaaa aacgcttttg ccgtcgatga tcgttaagcg 1034761 gctggaagaa ctgtttccgc atcataagga gcgcctgtta acaaatgaac ctgaacaggt 1034821 cagcgatgag gaacagctga tgtatgttgt gaataaaagc gtggcacagt cctttaccgc 1034881 gagccagctc aggttatgga ctcgggaata cgacatcagc gacgtctggt ggagcacgta 1034941 caatgtgctg atgagtgagc aggacaggct gcaatcgaaa aagctgttct caagcctgtt 1035001 tttccggaat gaagtgaagc agcttgaacg cagcgtgtcg agacagctct atggtgaacg 1035061 tattcagggc agtgtatcga gaatggaaac ctttaacgca tgcccgtttt cccattttgc 1035121 gtcacacggg ctgcatttga aggaacggca attcttcaag cttgaagcac cggatatcgg 1035181 ccagctgttt cattccagct taaagctgat ttcggacagg ctgcgtgagc aaaagctgga 1035241 ttggcgcgat ttaacgaagg agcagtgcga gctgttttcc tatgatgcgg tagagcggct 1035301 ggcaccgaaa ctgcaaaagg aaattctgct cagctcaaac cggcattatt atgtgaagga 1035361 aaaactgcaa aaaattgtga cacgtgtgtc cggcatttta agcgagcatg cgaaagcgag 1035421 cggattcgta ccgatcgggc ttgaactggg ctttggagga aaagggccgc ttccgccgct 1035481 gacctttcaa ctgaaaaacg gctgtacgat ggaactcgtc gggcgaattg accgtgttga 1035541 taaggctgaa agctcaaaag gcctgctcct caggattgtc gattataaat caagcgacaa 1035601 aggccttgac ttagcggaag tatattacgg attggcactg caaatgctga cgtaccttga 1035661 tttatcgatt acacattcag ctgactggct cgggatgagg gcgacgcctg ccggagtgct 1035721 gtatttccat attcatgacc cgatgattca atctaatctc ccgcttgggc ttgacgagat 1035781 tgaacaggag atctttaaga aatttaaaat gaagggcttg ctcctcggtg atcaggaagt 1035841 ggttcgcctc atggatacaa cccttcaaga gggacgttca aatatcataa acgccggctt 1035901 gaaaaaagac ggctctctca gatcagactc agcagcagtc ggtgaaaagg aatttgatct 1035961 tttgacaaag catgtgcgcc gcaccttcca agaagcgggc gaacaaatca ccgacgggcg 1036021 cgtatccatt gagccgtaca aaatgaagaa caagacgccg tgcacatact gtgcgttcaa 1036081 atcagtatgc caatttgatg aatcactgga agaaaacgag tatcgcccat taaaggctga 1036141 aaaggacaag acaatacttg agtggataaa aaaggaggcg gatggcaatg aacattccta 1036201 aaccggcaga cagcacatgg acagatgacc aatggaatgc cattgtttca accggccagg 1036261 atattcttgt ggcagcggct gcgggctctg gtaaaaccgc tgtgctcgtt gaacgaatga 1036321 ttcggaaaat caccgcggag gaaaacccaa tagatgtaga ccgtcttctc gttgtgacat 1036381 ttacaaacgc ctcagcggca gagatgaagc accgaatcgc agaagccttg gaaaaagagc 1036441 ttgtacagcg ccccggctcg ctgcatatta gacgccagct gtctctttta aaccgggcca 1036501 gcatttcgac gctccattcc ttttgcctgc aagtgctgaa gaaatattac tacttgatcg 1036561 atcttgatcc gggctttcgg atagctgatc agacggaagg cgagctgatc ggggatgaag 1036621 tgcttgacga gctgtttgaa gacgaatacg caaagggcga aaaggcgttt tttgagcttg 1036681 ttgaccgcta tacgacagac cggcatgatc tggatctgca atttctcgtt aaacaggtgt 1036741 acgagtattc ccgatcccat cccaacccgg aggcgtggct ggaaagcttt gttcatttgt 1036801 atgatgtatc agaaaagagc gccatcgagg agctgccgtt ttatcaatat gtcaaagaag 1036861 atattgcaat ggtgcttaac ggggcgaagg aaaagctctt gcgcgcgctt gagctgacga 1036921 aagcgccggg cggcccggcg ccgcgtgctg acaattttct tgatgatctt gctcagattg 1036981 atgaactgat tcagcatcag gacgatttca gtgaactata taagcgggtg cccgccgtct 1037041 cttttaagcg tgccaaagca gtaaaagggg atgagttcga tccagcgctc cttgatgagg 1037101 cgacagattt gaggaacggc gcaaaaaaac tgcttgaaaa gctcaaaacc gactacttca 1037161 cgcgaagtcc tgaacagcac ttgaaaagcc tagccgagat gaagcctgtc attgaaacgc 1037221 tcgtacagct tgtcatcagc tatggaaaac gattcgaagc tgcgaaacag gaaaaatcaa 1037281 tcatcgattt ttcggatttg gagcattact gtttagcgat tttgacagct gagaatgaca 1037341 aaggtgaacg tgagccgagc gaggctgcaa ggttttatca ggaacagttt catgaggtgc 1037401 tcgttgacga atatcaggat accaacctcg tgcaggaatc gattctgcag ctcgtcacaa 1037461 gcggtccgga ggagactggt aacctgttta tggtaggaga tgtcaaacag tcgatttatc 1037521 gattcaggct tgcggagccg cttcttttcc tctctaaata caaacggttt acagagagcg 1037581 gagaaggcac ggggcggaaa atcgatttaa ataaaaattt ccgaagccgg gctgatattt 1037641 tagacagcac aaacttttta tttaaacagc tgatgggcgg caaaatcggt gaggtcgatt 1037701 atgacgagca ggctgagctg aagcttggtg cagcgtatcc ggacaatgac gagacggaaa 1037761 cagagctgct gctgatcgac aacgcagaag atacggatgc aagcgaggaa gcagaagagc 1037821 ttgaaacggt gcagtttgag gcaaaagcca tcgctaagga aattcgtaag ctgatttcat 1037881 cgccgtttaa ggtgtatgac ggaaaaaaga aaacacatcg caatattcaa taccgagata 1037941 tcgtgatttt gctccgttcg atgccgtggg ctccgcaaat catggaggag ctgagagcac 1038001 agggcatacc ggtttacgcc aatttaacgt caggctattt tgaagcggtc gaagtcgccg 1038061 tcgcgctttc tgtgctgaag gtgattgata atccgtatca ggatataccg cttgcctctg 1038121 tgctgcgctc accgattgtc ggagcagatg aaaacgagct gtctttgatc cggcttgaaa 1038181 ataaaaaagc gccgtactat gaggcgatga aagactacct ggctgctggt gaccggagcg 1038241 atgagcttta tcaaaagtta aatacgtttt acggacatct gcaaaaatgg cgcgcgtttt 1038301 cgaaaaacca ctcagtatct gagctgattt gggaagtgta ccgcgacacc aaatatatgg 1038361 attatgtcgg cggcatgccg ggcggaaaac agcgccaggc caatttgcgt gttctttatg 1038421 acagggcgcg tcaatatgaa tcaacggcat ttcgcggctt gttccgtttc ctgcggttta 1038481 tcgaacgcat gcaggagcgg ggcgatgatc ttggtacggc gagagcgctc agcgagcagg 1038541 aggatgttgt ccgcttaatg acgatccaca gcagcaaagg gctcgaattt ccagtcgtgt 1038601 ttgtagcagg tctcggccgg aatttcaaca tgatggattt gaacaaatcg tacctgctgg 1038661 ataaggagct cggatttggc acgaagtata ttcatccgca attacgcatc agctatccga 1038721 cacttccgct cattgcgatg aagaaaaaaa tgcgcaggga gctgctgtca gaggaattgc 1038781 gtgtgctcta tgttgcatta acgagagcga aggaaaagct gtttctgatt ggctcatgta 1038841 aggatcatca gaaacagctt gcaaaatggc aggcatccgc gtcccaaact gattggcttc 1038901 tgccggaatt tgaccgctat caggcgagaa cgtatctaga tttcattggg ccggctcttg 1038961 ccaggcacag agacttgggg gatttggctg gtgtgccagc acacgctgac atctcaggtc 1039021 acccggctcg ttttgccgtt caaatgatcc attcctatga tttgcttgat gatgatctgg 1039081 aagaaagaat ggaagaaaaa agcgagcgcc tagaagcgat ccgccgaggt gaaccagttc 1039141 ccggctcgtt tgcgtttgat gaaaaagccc gcgagcagct gagctggacc tacccgcatc 1039201 aagaagtgac gcaaattcgg acaaagcaat cagtttctga gatcaagaga aaaagagagt 1039261 acgaggatga atacagcggc agggcccctg taaaaccggc tgatggaagc attctgtaca 1039321 gacgtcccgc ttttatgatg aaaaaaggcc tgacagcggc agagaaaggg actgccatgc 1039381 atacggttat gcagcatatc ccgctgtcac atgtgccgtc gatagaagaa gctgagcaga 1039441 cggttcacag gctttatgaa aaagagcttc tcactgaaga acaaaaagac gctattgata 1039501 tagaagaaat cgtgcaattt ttccatacag aaatcggcgg acagctgatc ggtgctaagt 1039561 ggaaggaccg ggaaatacca ttcagcttag cgcttccggc caaggagatc tatcctgatg 1039621 cacacgaggc agatgagccg cttttagtgc agggtattat tgactgtctc tatgaaactg 1039681 aggacggatt atatctattg gattataagt cggaccggat tgagggcaaa ttccagcatg 1039741 gatttgaagg agcggccccg atcttgaaga aacgatatga aacgcaaatt cagctgtaca 1039801 cgaaggcagt ggagcaaatt gcaaaaacaa aggtaaaggg atgtgcgctt tatttctttg 1039861 acggagggca cattctgaca ttatagcgag atccataagc tccggaattt caggcggagc 1039921 gggtctcgtt ttctatataa aagagaggtg aaagcatttg cggattttac atacggctga 1039981 ctggcatctt ggaaaaacgc ttgaaggaag aagcaggctg agtgaacagg ccgatgtgct 1040041 ggatgaactg aatacgattg taaaggatga gcagatcgat gccattgtaa tggcggggga 1040101 tgcatttgac accgtaaacc cgccagcttt agccgagcag ctgttttatg aaagcctgtc 1040161 tgcgcttagc gacagaggaa agcgcccgat cgtcgtcatt gccggaaatc acgataatcc 1040221 tgaccgtttg tccgccgctt caccgctgac acatgaaaac ggcattcatt taatcggtta 1040281 tccgacaaca gagccgattc atattgaagt gccttcagca ggagagcttt tggcggttgg 1040341 agcgctggcg tacccatctg aagcgcggtt aaatgaagtg ctatccgata cgtttgatga 1040401 aaagctgctc cgtgatcact atgatgtgaa aatcaggcag gcgtttgagc atatgacaag 1040461 ccggttccgg accgatgcag tgaagattgc cgccagccat atttatgtgg caggcggaaa 1040521 ccaaaccgat tcagagcggc cgattgaagt cggcggtgca tacacggtgg ctgctgaaag 1040581 cctgccggca gatgccgctt acgttgcgct cggccatttg catcgcccgc aaacgatcaa 1040641 gcgggcgcgg acgcttgcgc gttattcagg atctccgctc gcctacagct tttctgaagc 1040701 gggctacgct aaatcagtga cgattgtgga cgcaaagcct ggggaagagg ccacttggca 1040761 agaggtgtta ttatcaagcg gcaagccact tgtgaagtgg aaagcggcaa atggattaag 1040821 tgaggtgtac agctggctgg atgaaggcag agatcagaat gcttggattg acttggaaat 1040881 ccgtgtcgcg gaccagctgt cacttgaaga gattcacagg ctgcggaagg cgcacccggg 1040941 ctttatccat atcaggccgg tttttgaaga acagaacaaa gaccgggaac ggatcgaggt 1041001 taaacatgtc tcaatcgagg accgctttaa gaaattttat gaaaaacaaa ctggcggtgc 1041061 ggtgccggat gaagaaatgg tgaagctgtt tttagagctt gcatcaggcg ttgaagagga 1041121 ggatgcgaaa tgaagccgat cgccttaagc attaaggggc tccacagctt tagagaggag 1041181 cagacgatag attttgaagg cctttccggt gccggtgttt tcggcatttt cggcccgaca 1041241 ggaagcggta aatcctctat actcgacgca atgacgcttg ctttatacgg aaaggtggaa 1041301 cgggcggcga ataatacgca cggaatctta aatcacgccg aagatacgct gtctgtgtcc 1041361 tttacctttg cgcttcagac gaatcaccaa atctcataca aagtcgagcg tgtgtttaag 1041421 agaacggatg aaatgaaggt aaaaacggca ctttgccgct tcatcgaaat caaggacgag 1041481 catacggtgc tggctgataa agccagcgaa gtgaataaaa gagtggagga gctcttaggg 1041541 ctgacgatcg acgattttac gagagcggtg gtgctgcccc aagggaaatt tgctgaattt 1041601 ctgtctttaa aaggggcaga gcgcaggcat atgcttcagc gtttatttaa tttggagcaa 1041661 tatggagaca ggcttgtgaa aaagctgaga cggcaggcgc aggaagccaa tgcgagaaaa 1041721 aatgaaatgc ttgctgaaca gtccggtctc ggtgaggcga gctcagaggc agtggagcag 1041781 gctgaaaagg ttctcgaaca agctgaagcc cggctggaag cgatgaggaa gaaccgtgat 1041841 caggcgaagg agcggtttac agagcatcag gagatatgga atgtccaaaa ggaaaaatcc 1041901 acttatgaag aagaggaaaa acgtctcgca gaagaacagc cgcatataga cagcatgcaa 1041961 aaacgcctgc tggaagcaga aacagcagca gcccttaagc cctatgcgga ccggtacgca 1042021 gaagcgatcc agcatgagga gcaagctgaa aaggaacaaa cgctagccca aaaggattta 1042081 gcagaccgga cagctttctt tcagcaaaaa catgaagagt atgaagcgtg gcgccagcat 1042141 aaaagcgaga aagagcctga gcttttagcc aaacaggaac agctttcacg cttgcaggaa 1042201 atcgaaatca aactgagtga ggccaagcaa gaggaagagc gcaaaaaggc tgacctccgg 1042261 cagaaagaag aggctcttca atctgtcatg aatgaattag agaccgtaac agaccgcctg 1042321 acacgagggc aaaacagaca gacagaattg aagcagcagc tcaaatccct gcaggtgaca 1042381 tccgatgagc gaaaaagctg ccagcaggcc gcagagatgg cattgcgcat cagacaaacc 1042441 gaggaacaaa tcaaaaaaga gaaaaaacga agtgaagaat tgaacctcgt gctgcagaag 1042501 atgaatgaag agaagaatac actcgttcaa aagacggaag cggaagaaaa caacatcatt 1042561 caggcatatg aggcagttca aactgtgtac catttggtgt gcgaaacgga acgctcatta 1042621 acacgtatga cggaagaggc tagaaagagt caacacacgc ttcacttaca gcgtgaaaaa 1042681 gcaagggtgg cactgctgac aaaagagtta gcccaaaagc tgactgccgg aaagccttgc 1042741 ccggtatgcg gttcaaccga tcatgatcca tctgcctcgg tacatgaaac gtatgaagcc 1042801 gacagccatc ttgaagagga catcaaacgg acagatgtgt tattgacgga agctgcagct 1042861 ctcagccagg agattctttc agccaaaatt atgcttgaag aacagtccgc gcgctttatt 1042921 gaacagtgtc cgtttttgca gacaattcaa gcacagaacc ttgaagcggc agcttccttc 1042981 gaacatcagc cggtgtatga agcatttgaa actgccaaat ttgaatggaa acgaatcaag 1043041 caggacattc tttctgttaa gacacgaatg gcacaaatga ttggcgccta tcaggagtct 1043101 ttaaaaaagg ccgagcagct taatgaaaaa atcggttttg aaaaaagaga agccgaccgt 1043161 attgaaagca tcatcagtga gcttcaatcc tcaatggaca gcagtctgaa catgtttaaa 1043221 gaagcatttc agaatcaatc tgtggacgaa gcagaaaaat ggcagcaagc cattgaagaa 1043281 aaggaccggg ctgcagaaga atgtgaaaaa cgaattgaga agagtatcgc gtttcttgct 1043341 gagcatgaag cacaaaagga aaaactgcgg gaatcgggac accggcttga gcgggaaaag 1043401 ctggagcttc attatgcggc tgaacgcatc aagagcgtga tagctgatta tgagcacgaa 1043461 ctcggagatt atgcaaaagg agattcgatt caaatcaaac tccgctctgt ccagcaggat 1043521 ctaaagctgt taaaggaaaa agaacaatct ttatatgaag aactgcaaag cgcccaaatg 1043581 aagctcaacc aagcgaaaag ccgcgcttct gcaagcgagc tcactcttca agaggcgaag 1043641 ggcagattgg aaaaagcaaa agctgcttgg cttgagcata caaaaaacac ctccattacc 1043701 cggactgagg aggttgaaca aagtctcatc ccagctgatg aacttgaaaa gatgaaaacc 1043761 ggcatagacc agtttatgga taaactgaag caaaatgctg caaacttaaa acgagtagca 1043821 gagatacttg ccggcagagc attatcagag agcgaatgga acgaaaccgt tgcagcatta 1043881 caagaagctg aggacgcatt tggcgctgct atagaggaaa aaggcgcggc cgcaaaagca 1043941 ctggctgtca ttcgcgacca tcataaacgg tttaatgaaa ttgaagctga actgaaaaaa 1044001 tggcagatgc atatcgacag gctggacaag ctgcaagctg tgtttaaagg caataccttc 1044061 gtcgaatttt tagctgagga gcagcttgaa agcgttgcga gggacgcctc agcaagactc 1044121 agtatgctga caagacagcg ctatgccatc gaagtagatt ctgagggcgg cttcgtgatg 1044181 cgggatgacg cgaatggagg cgtacgacgc ccggtttcca gtttgtctgg aggagagacc 1044241 ttcctcacct cgctttcact tgctcttgcg ctgtctgcgc agattcagct tcggggggaa 1044301 tacccgctgc agttcttttt cttagatgaa ggcttcggca cactggatca agatctgctt 1044361 gatacggttg taacggcctt ggaaaaactt cagtcagaca acctggctgt cggtgtcatc 1044421 agccatgtgc aggaactgcg tgcacggctt ccgaaaaagc tgatcgtcca tccggctgaa 1044481 ccgagcggcc gcggtacgcg ggtatcactt gagttgatgt aagggaggag cggatatggc 1044541 aaagcagatt gccggaatat gtgagctgtg cggccggagc gatgtccagc tgacagagca 1044601 tcatcttaca ccgaaagagg aaggcggaac gtttttgccg acagcgatgc tctgtattcc 1044661 ttgtcataaa cagattcatg ccttatatac caatcaagag ctcgctgtac gtttaaatgg 1044721 aatggctgaa ctcagaagcg atccagagct tgcccggttt gtcaaatgga tcagaaaaca 1044781 gccgcctgag aagctgatca aaactaagaa atcaaatgaa cgaaaaaaga aaaaatgact 1044841 aaaaagcagc cctctctttg cagagcggct gcttttatcc gtttccaacc atatccggaa 1044901 gcaaaagttg ttgttgaaaa gtaaccaaaa agcggtgctc gatgcaccgc ttttttattt 1044961 gcgcccccgt tggactgctg tgtacataat ggatcgcttt ccgtttgaag ccgtccattc 1045021 aaaacggtct cctgtccctt cgctgctgta gttgtagtga tgctgcatcg cgcattgtgc 1045081 ggtgtcattt gaaaagtgat aaaaggacac accctgcccc gccgaagtat tcgaaaagac 1045141 tcctttatta taagaaaaga cgcaatcgaa taccgataag ccgaagctgt gcaagtgctg 1045201 cagaaatgcg agaaaggttt cgtcgtcaag cgaatccaaa agcgccatga gcggccgctt 1045261 gactgatttc tcatagcgga tgcgttctcc gccggaaagg gagatgtttt ctgcaccgca 1045321 tgccaaaacc aacttgtcct gaaagccggc ttgctcccac tttcctttat gatggatcca 1045381 gattgggctg tgttggagac tgtccgccag cagtatatcg ccttcaccgt tttcgattaa 1045441 gcagatgccg tcttcaatga ggatggtgcc gtattcccac tttcgttcct ctgtatataa 1045501 caattgtttc cgtttcatcc atgctgtctc ctttttcttc attcctctct tttctttcca 1045561 attcaagcct gtcccataca actcttttat ggacaaatca actatctgcc tatagatgca 1045621 taaacttact aaggtgctga aagaaacgaa attgttacga aagaaacggg attggagctg 1045681 atgtcacatg tgtggaatta cgggttgggt cgattttaaa aagcagctcg tccaggaaaa 1045741 acaaacgatg gacagaatga cagacactct ttccaaacga gggcctgatg attcaaacgt 1045801 ttggggggag caccatgttt tattcggaca taaaagactt gcggttgttg atattgaagg 1045861 cggacgccag ccgatggcgt gtacctataa aggcgatacg tacaccatta tttacaatgg 1045921 cgagctttat aacacggaag atttgcgcaa agaattgcgg gcgcggggcc atcaattcga 1045981 gcgtacgtca gataccgagg tgcttctgca cagctacatc gagtggcagg aagactgtgt 1046041 cgaccatctc aatggcatat tcgctttcgc tgtgtgggat gaaaagcgta atctgttgtt 1046101 tgccgcgaga gaccgtctcg gtgtaaagcc gtttttttac acgaaggaag gctcttcatt 1046161 tctcttcggg tcggaaatca aagcaatcct cgcgcaccct gatataaaag cgcgagtgga 1046221 cagaacggga ctttctgaaa ttttcggtct tggaccgtcc agaaccccgg gcactggcat 1046281 atttaaaggc ataaaagaaa tccgcccggc tcacgcgctg acattttcca aagacggact 1046341 taatatttgg cgttattgga atgttgaaag cgaaaaacat acggacagtt ttgatgacac 1046401 ggttgccaat gtcagatcgt tatttcagga cgcggtgacg cggcagcttg tgtcggatgt 1046461 gcctgtttgc acattcctat caggcggtct ggactcaagc gcgattacag cgattgcggc 1046521 gggccatttt gaaaaggaag gaaaagcacc gcttcatact tattcgattg attacgaaga 1046581 gaacgataaa tattttcaag caagcgcttt tcagccgaat gatgacggac catggattga 1046641 aaaaatgaca gaggctttcg gcacaacgca ccacaaatgc gtcatcagcc aaaaagacct 1046701 cgttgatcat ttggaggaag ctgtactggt caaagacttg ccgggaatgg cagatgtcga 1046761 ctcatccctg ctgtggtttt gccgggaaat caaaaaggac tttgtcgtca gcctatcggg 1046821 agaatgcgcg gatgagattt tcggcgggta cccgtggttc catacggcag atgttgagtc 1046881 tggctttcca tggatgagat caacggagga gcggatcaag ctgctttctg actcatggca 1046941 gaaaaaattg aatctgaaag aatacgtaaa tgccaaatat gaagaaacct tggcagaaac 1047001 gccattatta gacggagaaa cgggtgtgga taaagcaaga agacagctgt tctatttaaa 1047061 tatgctttgg tttatgacga accttttgga tcggaaggat cgcatgagca tgggggcgag 1047121 cctggaagtg cgggtgccgt tcgccgatca ccggcttgtg gaatatgttt ggaatattcc 1047181 gtgggaaatg aaaatgcatg ataatcggga aaaaggcatt ttgcgcaaag cgcttgaggg 1047241 cattttgcct gatgacattt tgtatcgcaa aaaaagccca tatccgaaaa cacatcatcc 1047301 ggaatataca aaaggcgtca gcgagtggct gaaaacgatc agaagccaaa aggactccgt 1047361 gctccatacc ttactggaca gaaaacaatt agatcagctt ttagaaacgg aaggctcctc 1047421 cttcaaggtc ccgtggttcg ggcagctcat gaaggggcct cagctgatcg cccatcttgc 1047481 tcaaattcat acatggtttg aagcgtatcg cattgatatt gacgagaggt aggttcaata 1047541 caaatgtgat taaaagccag agatgtatag atttaaataa gaaggataga tgagcaggga 1047601 aatatatgct ctatctatcc ttttttgtac aacagcacta tcgaattgcc cccgcattcc 1047661 ttcaataaga atgaataggt tttaatgttc tgccgataaa actagctgat accgggctta 1047721 actttaattc cctagcccat acagaaagtt gaccaatatg gtgaatttcg tgagcgatga 1047781 tatggtgtaa tatttcatct cgcgtatata aaacacctgt ctcccaagga acgcttacaa 1047841 gttcatcttt tatttgatct gaatgtgttt gtaaaacatc aattatttca gttcggaatg 1047901 tatttgagag agatttcact ttattgagtg tttgataatc agcgaactga acagcgatat 1047961 cttcttttcc ttggatagca cgaatccaac tatattccac atcaataata tgaaaaaggg 1048021 tatataaaat attctctact ccgccaagac gatttttaag taattcttca gtggttagtt 1048081 gatgacacca agtaaaccat tgatctctaa cctgccagtt atattcaaaa aatttcatca 1048141 ctaaactcac tccaatacta tcatgtatca taacaattag cccttttttc cgtgattcct 1048201 ctattaatga agtgatgatt gagaaatgtt tacattctac ctgttgtatg gcattaaaaa 1048261 taataatgca tatctcgtcg atgatgctgt gcgtcttgtt acttttacaa agtaagaatc 1048321 ggcattttct tcatatacaa ttaggaaaaa acatactaga cttgaagaag cagtgataca 1048381 taggagtgag aaaatgaaag agataaaaga agcttaccag caatgcggac agattgttgg 1048441 cgaatacgcg ccagcctgtt tcaaagcatt atcatatctc ccgctaaagc aaagacaagc 1048501 ctcttgggca gtattgtcgt tttgccacac ggcggccagt gcagacgaaa aggtattgcc 1048561 cgcatttgaa gctaaagctg atcatgttta ccaaaggaca aataacggta aacaacatct 1048621 atggaaggct tttgatcatg cgtatcggac ctttacattg gaaagcgaac cttttcggga 1048681 gtttattgcc gcacaaaaag aagacgccaa gccgtatgat gaccttgatg aactgctcat 1048741 gtacgcatat cggacgggcg gtgctgccgg attgatgctg ctgccgatac tgacacgccg 1048801 aaaacaagat cagctcaaac aagcagccgt ctctctcggc ttggccatac agctggttcg 1048861 cttcttaagt gatcttggca cagatcagca aaaaaaccgc attccccgtc aggtaatgca 1048921 gcaattcggc tatacagagg ctgatctcca aaaaggcacc gtaaataaag cgttcacaat 1048981 gacgtgggag tatatcgctt ttgaagcaga agcctacctt gaagagtgtc aggatgcctt 1049041 gccgctattt ccgcagtatt ctcaaaaaac ggtgaaagcc gctcttcatt tgcaccgggc 1049101 tgttttagaa aaaatccggg cgaagcagca cgatgtattt caatatcact tcgctctcac 1049161 agagaccgaa gtgaagcaga ttctgtctga tatctaaaaa acacccggcc ttgattgagc 1049221 cgggtgttac gccatacctt tttgaatcca gatacgtgag cgccatcttc tgtacattaa 1049281 gattccccgg acccattcat ccgcgataaa agaaatccaa atgccggcaa gaccgaaacc 1049341 gaggtggatg ccgaaaagat aagcaagcgg gaggccaatg ccccacattg aaatcattgc 1049401 catgtaaacc gggaatttcg catcccccgc ggcccgcaga gagttaatga taatgacatt 1049461 aaacgagcgg cctggttcaa ggataatggt catggcaatc aataggcttg cagttgctat 1049521 aatgtcaggg ctttgtgtga agagtccgat caggtctttt gaaaagatcg tcatcaaaac 1049581 agaggtagcc gcagcaattc cgagtgccca atataagctc ttcatgcagc gctcataagc 1049641 ggcatcaaat tgtttgccgc cgatataacg gccgattaag atttgtgtac cctggctgat 1049701 cgcagtgccg aacagcaaaa taaacatcgt aatattttgc gtatacactt ttgttgtcaa 1049761 cgcctgcgcg cccatgatgg cgataaaata cgtgactatc atttgcgaca ggttgtatga 1049821 aagctgctct cccgcagaag gaatgccgat tttcagcagc ttgcgcaaat gctctttatg 1049881 catatgaaag acttttttca gcgacatctt cagctggatg cgtttgttga caatcacaat 1049941 catcgcgatt aatccgatga cgcgggcgat agatgtggac atggccacac cggcaacacc 1050001 gagaacagga aagccgaaca aaccgaaaat cacaacaaag tttccggcaa tgtttaaaat 1050061 gttcatgccg atagtgacaa acattgtatc ttttgtgtag ccgtagcttt ttaagatcgc 1050121 gctgaatgtc atgattaaag cctgaataaa ggacagacct ccgacaactt gtaaaaagac 1050181 tttcgcatca ggcatcagtg cgtctgataa tcccatcata tgaagcagag ggacagccgc 1050241 gaaaaagacg acggcgctga tggccaggct gatgaagaag ttggcgccga ttgacacata 1050301 agcgacttcc atggcttctt tcttttgccg tgagcctaga aattgtgaaa tgataacggt 1050361 cgttcctgtt gcgataaagc tgaacatcac gataattaaa tttaaaatct ggttgctgac 1050421 gccgactgct gccacgctgt tatccgagta ttggctgagc atcagtgtat cggcattacc 1050481 cataaacata tataatgaga cctcaataaa gatcggccaa gtaagcgaaa ataatgagaa 1050541 cgttttgtca gcgggttttt tcaaagcagt tgatttgaag acagcttgtt tcatcgtgtc 1050601 taaccccttt cgtaaataaa atcaacgttt taaagtgtac ctccatttcc ttataataaa 1050661 aagggataga aacgatactt cttgtaaaaa tccgacttaa aaaggaggat gattcaaatg 1050721 cctcgcatcc tgtttacagt cccgcctttt ccggtattta tcgcagctgg ggaaggggtt 1050781 tttaaaaaag gagaaaccca tgtgaaacgt gtattctccg tgtttgatct gatatatgtc 1050841 aaacagggaa cgttatatat aacggaaaat gaaacatcgt tttctgttga aggcggcgag 1050901 tacatcttgc tttctcccgg tcttgaacac tacgggacga agggcagtga tgaagcaacc 1050961 tcctactatt ggcttcactt cgatgaacat cgatatgaat ttacggcaaa gggaggcagc 1051021 aactggtctg agcttcagca ggaaaaaggg agcttcgaag agctggcccg ctacggattg 1051081 gccttgccga gaaaaggcaa ggtgcagcgc ccgcagttta tggcgcagca gtttgaaaag 1051141 ctgatcgatt actccgcgga aaactctgat ttgccgctca gaaagcaaat tttatttgag 1051201 gagctgatgc tgcatcttca aaaagaagcg ttccaaatac cgtctgcgaa agagcgggta 1051261 gcctgggagg cggcccggta tttacaggag cactataagg aaaagacgac aatcaaggat 1051321 ctgtcgctcg cccttcacta tcatcaggat tatgtgagcc gctgcatgca gcaggtgctc 1051381 ggcgtaactc cggcacaata cacgaaccgg gtgagaatga cggaagcgaa gcgtctttta 1051441 tcctctacaa atgataaaat gggcgttatt gcggaaacgg tcggaatgga agatccgaca 1051501 tacttttcaa aactctttaa gcagatagaa ggcatttcac caattgaata ccggaaaatt 1051561 gtcagccgga aagttcaata accagacgag ggatgaacat gaaaacaaca atttacgatg 1051621 tggcaaaggc ggcgggtgtt tcgatcacaa ctgtgtcccg tgtgataaac aatacgggga 1051681 gaatcagcga taaaacacgg cagaaggtca tgaatgtcat gaatgaaatg gcatacacgc 1051741 ccaatgtcca cgccgcggcg ttaacgggaa aacgaacgaa tatgatcgct ctcgtggcgc 1051801 ctgatatttc aaatccgttt tacggcgaac tggccaaaag cattgaggaa agagcggatg 1051861 agctcggttt tcaaatgttg atttgcagca ccgattacga tccgaaaaaa gaaacaaagt 1051921 atttttctgt gctgaaacag aaaaaggtgg atggcattat ttttgcaaca gggattgaaa 1051981 gccatgacag tatgtctgct ttggaggaaa tcgccagtga acaaattccg attgccatga 1052041 tttctcagga taagccgctt cttccgatgg atattgttgt gatagacgac gttcgtggcg 1052101 gatatgaggc tgccaagcat cttctgtcac tcggccacac gaacatcgcc tgcattatcg 1052161 gagacgggtc aacgacaggc gaaaaaaata gaatcaaagg cttccgtcag gcgatggagg 1052221 aagcgggcgt gcccattgat gaatcactta tcatccagac gcggttttcc ttggaaagcg 1052281 gcaaggaaga agcgggaaaa ttgctcgaca gaaatgctcc gactgctatt tttgccttca 1052341 acgacgtatt ggcttgtgcc gccatacaag ctgcgagaat aagaggcata aaagtgccgg 1052401 atgatctttc tatcattggt tttgataata cgatactcgc agaaatggcg gctccgcccc 1052461 tgacaaccgt agcccagccg ataaaagaga tggggcggag cgtcatcgaa ctgctggcag 1052521 aagcaataga gggaaaacga aaggcgaaac aaaaaatagt gctcccgcct gagcttgtag 1052581 tcagacattc tacatcaccg ctcaacacat gagcccgcta atgagcgggt tttttcatta 1052641 tgacagttga agccaaaaaa acatattgcg tgtaaaccaa aggcggtgta aaatataacc 1052701 atcttttgag aaagcgcttg cgcaaaatgg cagagcggat agaaccgctg tttttttagc 1052761 tgttaagaga aaacgctttc tcaaagcgag cccgaaatga gataaaggag aggatgggac 1052821 gtggaacatc aagtaagatg tgcagtattg ggattaggaa ggctcggtta ttatcatgcg 1052881 aaaaatctcg tcaccagtgt gccgggggca aagctggttt gtgtcggtga tccgttaaaa 1052941 gggagagcgg agcaggttgc cagagaactc ggtatcgaaa aatggtcaga ggacccgtat 1053001 gaagtgttag aagatcccgg cattgatgct gtcattatcg taacgccgac aagcacacat 1053061 ggtgatatga tcatcaaagc agccgagaac ggcaaacaga tctttgttga aaaaccgctg 1053121 acattaagcc ttgaggaatc aaaagcagct tctgaaaaag ttaaggagac aggtgtcatc 1053181 tgccaagtcg gctttatgag acggttcgat cccgcatacg cagatgccaa acggcggatc 1053241 gacgctggag aaatcggcaa acctatctat tataaaggct ttacgcgcga ccaaggcgcg 1053301 cctcccgcag aatttatcaa acacagcggt ggaattttta tcgactgttc catccatgac 1053361 tatgatattg cccgttattt gctaggggcg gaaatcactt ctgtttcagg acacggcagg 1053421 attctgaaca atccgtttat ggagcagtat ggcgatgtgg atcaggcgct gacgtatatt 1053481 gaatttgact cgggcgcagc gggggacgtc gaggcaagca gaacctctcc atacggacat 1053541 gacatccggg cggaggtgat cgggacagag ggcagtattt tcatagggac attgagacat 1053601 caacatgtga ccatcctatc ggctaaaggg agcagttttg atatcattcc agactttcaa 1053661 actcgttttc atgaagccta ctgcttggag cttcagcatt tcgccgagtg tgtccggaat 1053721 ggaaaaacac cgattgtgac tgatattgat gcgacgatca atttagaagt gggtatcgcc 1053781 gcaaccaatt cctttcgaaa cggcatgccg gtacagctag atgtgaagcg cgcttataca 1053841 ggtatgtaaa agctaagtat gttgcatttg aggctttccg caaaaaaagc aagggcattt 1053901 tagcccttgc tttctctttt ctcatataaa tagtacatat aatcagtagg tacgcctgaa 1053961 tggtccagct gtctcagcat ggcggttacg ttccctctgt ggtaagtgcc gtgattgacg 1054021 acatgcagga tggtgtctgc ataggttgat tccagtgtac ctagtttcgg atgctgcatt 1054081 gtgaaggtct gttctaagtc cgtctggcgg ctgaagaaat catgatactg tgactccagc 1054141 tcggcagcgt gctgtttaat cgctgccata ttaccttgcg cggactgtaa tttgcctgcg 1054201 ctgtctataa tctcttggta ggccactccc gaaagaacat tcagccaaat gtagtcagcc 1054261 ctgcacatat gaagcagcac gtcgctgaca gaaggaaata cgctctttac ttcttgatag 1054321 gcagtttcct ccggcaggtt ttcgatatgg gtaaatattt tcttgtttgc ccaagaatga 1054381 tagtcataaa actgttttgc atcagtcatc agcatgcccc cttttctaag aaattcgttt 1054441 ttttcatctg tttctccttc aattgcaaaa gagtgacacc ccaaaatatc ctgccgctgc 1054501 ccacattacc gctgcagagc atttgtttac gatcagcata agcctgccgc tcgtatctat 1054561 cgtctgaaac aaccggcccg ctattgcaag gctgatgaac caaatccaag acacagcgat 1054621 gcaggcggcc ataaagagcc atttctcaag ccccgaatat tgaagagagc tcgtgccgat 1054681 gacgccgatc gtgtccagaa tggcatgcgg gtttaaaaga gaaacagcgg ccgcaaacgc 1054741 agcttgcttt tttggtgtga acgtatgttt ctcattttgg cttgtgttcg gacggatgtt 1054801 ccaagtcacc cagcccatat aaagcaaaaa taaaaatccg ccggccatca tgactgtctc 1054861 aaacacaggc agctcctgca caatgacaga cacgcccgca acggctaata caattaacaa 1054921 ggtatcgcag actgaagcac tgatgacagc tgggagagcc cgccaaatat gcttttgcaa 1054981 cgcgccttgc tgaaaaataa acacattctg cactcccagc ggcaaaatta agccaaacgc 1055041 gagcacaatt ccgtgaatga ttgcattcat gctgaaaaag ctcctttcac attttttttc 1055101 aatcataaga gagattgtca ctaaagtctc cagccatttg gttgggttag gaaccagcca 1055161 aatgtataat gtgtaaaaaa ggggggcatg accttgtcgc aatggcagcc aagccgaaag 1055221 tcggatgttc cgctgcatcg gcagatcgaa caatatatga aagacaagat tcttcacgga 1055281 gagtgggctg tagggacgaa aatcccctca cagagaacgc tggccgacat gtttcaagtc 1055341 aaccgcagca cagtcacagc agccatagat gaactcacgt ctcaaggctt gttagaggga 1055401 agaaaaggcg gcggtacgaa ggttgtaaac agtacttgga gcgtgctgac ggctgagcct 1055461 ccgcttgatt ggagcgatta cgtccgttcg ggcattcatc gcgccaattc ttccatcatt 1055521 caagctatta atcagaacga accaagagcg gatatcatca gattaggaac tggagaactt 1055581 tcaccggatc ttgtgcctgc tgacacaatt ggacggatgt ttcagcaaat caatccgggc 1055641 gtcctgtctt taggatatga gcagccgaaa ggaaaccgtc agctgcggga ggcagtggcc 1055701 gaccatttaa aaggaaagaa gatccatgtg tcaccgtctg caattttaat tgtgtccggt 1055761 gcacttcagg cacttcagct catctcaatt ggacttttaa aacgagattc tgtcattttg 1055821 acggagaagc cgtcctacct tcaatccttg catgtatttc aatcagctgg gatgcggctt 1055881 cgcggcttgc cgatggatga tgaaggggtc aaagcggggc ttgtttcttc taatcgaaaa 1055941 caatatggag gacagctgct ttacacgatt ccgtcgtttc ataatccgac aggcacagtc 1056001 atgtcagagc agcgaaggaa agagatcatc agcctgtcaa aaaaagagca gatgcccatc 1056061 attgaggatg atgcgtacgg tgatttatgg tttgaagaaa aaccgccgca gccgttgaaa 1056121 gcaatggatc atgagggcaa tattctgtat ctgggcgcgt tttcaaaaac ggttagcccc 1056181 ggtctgcgaa tcggctggct tgccggtccg gagccggtta ttgaaaggct ggcggacatt 1056241 aaaatgcaga cagactacgg atcaagcggc ctgtcccagt gggcggctgc cgagtggctg 1056301 tcacagggat attatgaaga gcatctgact tgggtacgca ggaagcttaa agaaaggaga 1056361 gacgccgccg ttcattttct cgagcggtat gccggggaca ttgccacgtg gcggattccc 1056421 gcaggcggct tttatatttg ggtgacattt cacaaaaacc tgcctgtcag ccgtttcttt 1056481 tatgaattgc tgaaacggca ggtgcttgtg aatcccggct atatttatga cggtgaagac 1056541 cgaaacagca tcaggctgtc atattcctat gcatctcttg gagatttgga aactggcatt 1056601 aaagcggcag ctgaaacagc acgccgcctg atgatgtcct aggctttggt tatacgatga 1056661 cagctcccag tgccctggcg aaggcaatcg cgtgctcagg tgcgattttg cagcctttca 1056721 atttgtcgag ggagacatga agctgttcaa aacggcacgt gctgatgtcc atgttttgaa 1056781 gggacgtgcc ggtaaagctg gcgccttcca attcgcatcc gtcaaagtgt gtctgctgga 1056841 gcaccgtatc gctgcattca ctttgcataa gagcacagtg atcaaatcga acttgtttca 1056901 tatttgagta cgaaaatgag ctgaaatgtc cgtggcattc ctcgaatgaa acattccgca 1056961 gcgttgcttc cgccacattc attccaacca tttttgactg cttaactgaa gttctgtgaa 1057021 tgacagcccc gctgaaatcg gcgtttgata aatcgcattt ttcaaagatc acatcggtca 1057081 gttcaatatg ccgaaaagac acatcgataa agacgacatt tctgaatacc gttttttcaa 1057141 cacatagtct ttcgatatct tcgccgcaga tggtgcaatc ttcaaacaaa tgcatgctga 1057201 ttacatcatc ctgtgtcacg gcatcatgaa aatctgcggt ttgcaggttt tccggtatgt 1057261 tcggtttttg aattgcgatt ttattcatgt gatgacatcc tttgctgccc gaaaaacaga 1057321 ggcttccggg ttcaatttaa tagatcgtta aggaaattga tacatatagt aaatcgtgaa 1057381 gagccttttc ttggtacagc agcccgcttg ttttgtaagc ataaatggaa agcttcctat 1057441 acgtcaaggc gtttacaggc cgaaaaagcc aaagggaaca ggaggaatgc ggaatggggc 1057501 attacatcaa aaccgaggag catgtgacac tgtttgtaga ggatatcgga catggaaggc 1057561 cgatcatctt tttgcacggg tggccgttga atcataagat gtttgaatat caaatgaatg 1057621 agcttccgaa aaggggattt cgttttatcg gcgttgattt gcggggatat gggcaatctg 1057681 accgcccttg ggaaggctac gattatgaca cgatggccga tgatgtgaaa gcagtcattt 1057741 atacgctgca gcttgagaat gcgattcttg ccggtttttc aatgggcggc gcaattgcaa 1057801 tccgttatat ggcaaggcat gaaggagccg atgttgataa gctgatttta ctgtctgcgg 1057861 cggcccccgc gtttacaaaa cgcccgggtt atccgtacgg gatgaggaag caggatattg 1057921 acgatatgat tgaattgttc aaagctgatc ggcccaaaac actggctgat ttagggaaac 1057981 agttttttga gaaaaaagtg tctccagagc ttaggcagtg gtttctcaat ctgatgctgg 1058041 aggcttcctc ctacgggacg atccactcgg gcatcgcatt aagagacgaa gatctcagaa 1058101 aggaacttgc tgcaatcaag gtgccgacgc tgatcctgca cgggagaaag gatagaattg 1058161 cgccgtttga ttttgcgaaa gaattgaagc gcggcatcaa acagtcggaa ttggttccgt 1058221 ttgcaaacag cgggcacgga gcattttatg aggaaaaaga gaagatcaac agtttgattg 1058281 cgcagttctc caactcataa gaaaaaaccc gacattgatc gggtttttta tataattcct 1058341 ctgttttgca gtgcgttaat gatgagatca gctccatcgg aaatagaggt ctggtcagac 1058401 tcaatgatga aatcgggtga aagcggcgct tcatacggag aatcgatccc ggtgaaatgt 1058461 ttgatctctc cgtttcgcgc ttttttataa agcccttttg gatcgcgctg ttcacaaaca 1058521 tgcagcgggc acttcacata aatttcgaag aactcacctt taggaaagag cgctctaacc 1058581 atgtcccgat cctctctgaa tggagaaata aaagccgtta aaatcatttg cccgctgtcg 1058641 acaaacagct tcgccacttc tccgatccgg cggatgtttt caatcctgtc accagtctga 1058701 aatccaagat ctttgtttaa gccgtggcgg atattatcac cgtcaagcac gtagctctga 1058761 atgcccttgc ggtaaagctt ttcatcgaca gcattggcca gcaccgattt tccggagccg 1058821 gacaaacctg taaaccaaag gacgcagctt ttgtgtccgt ttaaggactg tctgtcagac 1058881 tttgagatgg cagcgggatg ccaaatgatg ttcggattgt gtgtcattgc aattccccgc 1058941 tgttttgctt gatggcaaca ggctgttggt gaagtccctt gatcagcacg gctgcgacct 1059001 caggccggct gaattcttta ggcggctttt tgccttggcg gagaagctct ctcacttttg 1059061 tgcctgataa gtggatgtgg tctctcgggc tgtgcggaca tgttttggag gtgcccatgt 1059121 ttccgcattt tcggcaataa aagctgtgct caaaaaacag cggcttgatg cccagctctt 1059181 cctctgtgaa tgattgaaaa atattttggg cgtcgtatgt tccatagtag ctgccgacac 1059241 ccgcgtgatc acggcctaca ataaaatggg tacagccgta attttttcgg acgagcgcat 1059301 ggaaaatcgc ttcccgcgga cctgcataac gcatggcggc agggaaaacc gataacatga 1059361 cacgatcctt tggataatag tgattaagca aagcctggta gctctccatt ctgatatcgc 1059421 tggggatatc gtctgacttt gtttctccga caagtgggtg aagcagcaga ccgtcgaccg 1059481 tttctaacgc tgttttttga atgtattcat gcgctctgtg aacagggttc ctggtttgaa 1059541 agccgacaat cgtcttccag ccgagttttt gaaaggccgc tcttgtttca gcgggcgttg 1059601 cataaaactg ttcgaaagat ttgtcaggca ggctgctgac cgtgataggc cctccgatat 1059661 agtaatccgg gcgcgccagc aattttttta cgcctgggtg ggcaggatcg tttgttttaa 1059721 aaacagacag tgcttcttgt gttttatcag gctggtatat atcggtgact gtgatcatgc 1059781 cgtaggtaac accgtctttc acaagcttga cgtgatctcc ggcagacagc tgtcttgctg 1059841 ttttttctcc gacaggcagc gtaatcggca ggctccacgg caagccgttt gccagcctca 1059901 tctctttcac aacggaatga taatcttttt ctcccaaaaa acctgttaac gggctgtagc 1059961 cgccgatcgc aataagctcc agatcactca gtgcaagctg atccagctct gcttggcacg 1060021 cgcacccttc aaaatggcat gcgggatcac agcggttgat taatacccct ccgtggggtt 1060081 cgtttccatt caacgtgttc aacctccatt tatacgtttc cttgttttct tttctgcact 1060141 taatgaaagt ttgacatcag cgccttaaca tcatttcgat tctcacatca agaacctgcc 1060201 atccgctatt cttgatgcag gccgcattct gttttctccc gtccggccca tcttccagcc 1060261 ctctcatcgt tcgggtccgg ggaaggcagt gtacacattt cacagcctat gctcggataa 1060321 tgttgatcgt gcagtttgtt ataaggcaaa ttgtgcaggc ggatgtacgt ccaaacgtca 1060381 tcccatgtcc agtggataag cgggcaaatt ttgatgagct caaacttctg gtccaggttt 1060441 acgtattgaa tatgctttct cgttggtgac tgatcccggc gcagtcctga aatccaagct 1060501 gtcatgccgg acaggtgctt tttgagcggt tcgattttcc gcaattggca gcagaggttc 1060561 gggttatgct tccacagctc tccgccgtac ttcgtcccct gttctgttaa gctcagctcg 1060621 ggttcgagca tctggattgc aaatcccgga tatcgttctt tgacggtctc gatcagctca 1060681 tatgtttcct gaaaatgaag cccggtatcc aaaaagatga tgtgtgcgtt tttgttgatt 1060741 tttgatatta agtcgagaag caccattcct tctgcgccaa agctgcaggc gtacacaatc 1060801 ttttctccgt acgttcggta agcccatttc aacacatcga gctcatcgat caattgatcc 1060861 gttatctgtt tggacagcat gtcgttccaa gtgtcatatg tgatggtttc gttcaatgtt 1060921 ttccccccgt ttgcatctgc tttttttatc tattgatcga gttataggca gactattcat 1060981 tttttgcata aaggttcagg ttttaggtgc cgcgcccgcc taaaatgagg tgcggaacca 1061041 ttaagagccc ggctgaatat gctttttagc aaaatggttt tatgcccaag gagaggtagt 1061101 atgccgattg ccatttatca ggggcatcat cattcgcttg ccccggcgga cattaacatc 1061161 gtcattgatg tcatcagagc ctttacggtc gcccattatg cgtttatcgg cggggcgaaa 1061221 gagattttgt tggtccggac agctgatgaa gcctttgcgc tgaaagacac ctatccggat 1061281 tatgttttga cgggagagga aaagggggtc ggtatcagcg gatttgattt agataattct 1061341 ccaaaacgta tggctgggca gaatatgacg gataaaagcc tgatccagaa aacaacaaac 1061401 ggcgtcacag cagcattggg ggcgctgaac gcaaagcatc tgttcgtaac tggattttcc 1061461 aatgccaaaa caacggcaca gcatgtgaaa aagctcgtcg caaacgattg tgtcataaac 1061521 atagtggctt cccatccatc cggtgatgac gatatggcat gtgcggagta tatcaaaggc 1061581 atcattgaag ggacaaatgt ggtaacggct gcggaggcga ttgaaagaat aaaaggctct 1061641 tctgttgcgg agaagttttt tgactgccgc cagccattgt ttgattcgga agacatcgtt 1061701 tactgtacaa aagaactgac gggcgatttc gtgatgaaag tgaaacaaga tggagaagtt 1061761 ccaacgatag agagggtcat aatatgaatg atttttcact agaattgcca gtgagaacaa 1061821 acaagccgag agaaaccggg cagtccattt taattgataa cggctatccc ttgcaatttt 1061881 tcaaagatgc gatagccgga gcgtccgact atattgattt tgtgaaattc ggctggggca 1061941 catcattact tacgaaagat cttgaagaaa aaatcagcac actgaaagaa catgacatta 1062001 catttttctt tggcggcaca ctgtttgaaa agtacgtaag ccagaaaaaa gtgaatgaat 1062061 ttcatcggta ctgcacctat ttcggctgtg aatatattga gatttcaaac ggtacgctcc 1062121 cgatgacaaa taaagagaaa gcggcttaca ttgccgattt ttctgatgaa tttcttgtgc 1062181 tcagtgaggt gggcagcaag gatgcggaat tagcaagccg gcaaagctct gaggaatggc 1062241 ttgaatatat cgttgaggat atggaagcgg gcgcggaaaa agtgattaca gaagccagag 1062301 aaagcggaac gggagggatc tgttccagca gcggcgatgt caggtttcaa attgttgacg 1062361 acatcatttc ctcggatatt gatatcaaca ggctgatttt tgaagcgcct aacaaaacgc 1062421 ttcagcaagg gtttattcaa aaaatcgggc cgaatgtgaa tcttgccaat attccatttc 1062481 atgatgccat cgcgttggaa acgctgcgtt tagggctaag atccgatacc ttttttctgt 1062541 aaaatagcgg ctgcggggct ctcgtcgtga agagagcctc tgcctattat tttttatggc 1062601 ggtacatagg cgtgagatag ggaagtgagg tcaggcggat gttgtagatg aagtcgatga 1062661 ctcttgtcga tatcacctgg catatgaggg cttgaatgac gatgccccag tcaataatag 1062721 acgcggtgac cataaaaatg atgcaattca tgatgagcag gatcgttcca ggattcccgc 1062781 cgcggtagat agaaatcatc agagcaaggg ctccgaatcc tccgttcgaa attttatatt 1062841 tgtataaaag tccgattccg agtcccaata acactgcgcc gcttgccaga tcaagccaca 1062901 ggttagatgt gatatcagga aaaactgcat caaagatcaa taccgagaca gaggtgacgg 1062961 tgatagaagc gagggtgccg gtgaatgttc tcatctccag ccattttaaa gcggtaaaaa 1063021 gcattgatac attcacagcc cacactgaaa atccgtgggg gatttgaaac agataatgca 1063081 atagcaccgc aatacctgct gcaccgcctg tcggaatatc atgcggaaat aaaaacaagg 1063141 acatgccgag tccttgtagt acgccgccta cgacaatcat aaacgtaagt tttgctttca 1063201 tcagcagttc agccattaag tcatttgctc ctttatgaaa agacttgtcc gctgttttca 1063261 ttttatgagg ctgtccatta tttatgtctc aaaataaaga aatggcccag cttaataggc 1063321 tgagccatcc cacttgtagc gattgacgat ctccatattg atctctgtgc caatgccttt 1063381 tcctttcggg atgtggacca ttccttttga aggctgcagg ctgacgagat ctgtaaaagg 1063441 attctccatg acgtcccact cgatcggttc aatgtgatcg ttcttcattt tagaccatgg 1063501 gggcagacag gcttgtgcaa ataaagcata gagccgtgag agcgatccgt catatgcatg 1063561 ggcggatgct ctgacgccga aataacgcgc gagctggagg cagtcccgaa actcatcaat 1063621 tccgttgaca tgcatgacat cgggctgaat gatatccaaa cagcgctgtg aaaggagagg 1063681 cacatattgc gccgggcctt tcatgttttc tccgccggca acaggaacag acaaacggct 1063741 tcgaagcata gcgtaatcct gcggctgatc aaagggcaaa ggctcctcaa gccagccaat 1063801 gttcgtccat tcggagaaat agcgctccca tttaaaagcc gcagcggcat cgtagctttg 1063861 gtttgcgtcc agaatcatcg taatggagct gcctgctgta tgctgcagcg cattgatgtg 1063921 ccggacatcc tccttgaatg aagtcccgcc aattttgact ttgatttgct caaaaccttt 1063981 tttcaactgg gcttcaacat tggagactga gcggctgatc cattgcgggg agtctgagta 1064041 cgattgaaaa gacgcgtaca caggaatctc ctctctgtat cgcccgcccc ataattcgca 1064101 aaccgaacaa tccgcagctt tggctgcaat ctctgtcagc gccatgctta cagcggaggc 1064161 cgcccgctgg tgccattttt gaatcgtgcg cactaatgac aggcggctgc cagcctgttt 1064221 tcctaataga aatgggatga tccgcttcgt aaaaccgaca tggagagcag ggagccaatc 1064281 aacgcattct ccccagccgt ctatcccgct ttcggtgata atcctgatga gataacaagt 1064341 ccgatatcgt ttaaacccat tggcatctcc gtatggcttt tctaatcgat gaaatagcgg 1064401 aaaggtttca atccgtacaa ttttcacact gggtgctacc tttcctcagc gggctggagc 1064461 cgattgccag ccattttagg gtcttctttt tcttttgttt cttcattgtt ttgcttcaca 1064521 tggatgagca tcatcacaag aatcccgaca acgagagtca atcccgcgat gcttaaaaac 1064581 atgccgggtc tggaccattg catcaggcgg ccgaaaatcg gaggaccgat cgctacccct 1064641 aagaaacgta cagagccgta cagcgaggtg acaaatcccc gtctttcttt gccgacagcc 1064701 ccggtaatga aactgttcac acaaggaagg acaagacctg agcctatact gctcagtaca 1064761 agaacactga taaaaaggac aagattttca atgaatgaca gtgccgcgta ggatacggtc 1064821 atgaacgcca atccaagtac gatcagcttt ttcattaacg attgcttttg cccgattttg 1064881 cttcctgttg tataggacgt cacacacata accaaaagcg ggatcgctaa aattaagcct 1064941 tttttcacgc cgtcggtgtc gtatgttttt tcaagaacat ctgagagata aaacaggatg 1065001 ccgaataaag taaacaaaca ggtcgcaccg gctaaataag cggtaaacag ccatctgcct 1065061 tcatgtttaa agacacttaa cagccctttt gcatattgtc cgattggtgg cggttctttt 1065121 tcctttttct tttctttaat aaaaatccaa gtcagtacga tcgaaatgat acaaaacaca 1065181 ggaaaggcaa aaaacgcgcc ataccagaca agcagggcga tcagcgagcc aatgatcggc 1065241 gatagcactt tccccatgcc gtttgaagct tcaacaaggc cgagcacctt gctctcctgg 1065301 gcgcctttaa acagatctcc cgtcagtgcc atggcaattg ggccggttcc ggctgccccg 1065361 attccctgta acgctcgtcc tgccatgacc caaggatagg cattgtcaaa aaaacctgcc 1065421 gcaaacccgg ctaacaaacc gccggcacca tacaaaatta agcagggaat aatgatgact 1065481 ttccttgaga atcggtctgc gagataaccg acaatcggaa tcgcaaatgc tgcaatcaag 1065541 gaaaatactg tgatcacgag actgacttga aattgtgata aatgaagttc agatttcatt 1065601 tttggcaaaa tcggaataag catcgagttt cctagggtta atattaaagg gattgaaccg 1065661 attgccacaa tcgtcattcc gttattttgt tttgatgatt ccatctcaga gcacactcct 1065721 tttcttctgc ttagaatgtc cctgatggct tcgtttattc agcgatcaga cagcaaaaaa 1065781 ccgaacagaa gatacctgtt cgggaaaaaa gagggttaac cgagagcctg tgaaatcaaa 1065841 gcatataagt gtccattttg aataggcgct tttttctgat agaacaaaat cggaggttca 1065901 tcatctttat gaaatcccat ttctatcagg ctgtcatgca gagacgtgtg ttcactcggt 1065961 atatcgattc gcatcggccc ttgtttgccg gccgccagcc ttgtaattat ctgtgctgca 1066021 acatctgatg atggagcgat gatagggccg aatttcaaat tggccggtgt ctgtacagaa 1066081 agtccgtagc caatgagctg tccgtcctga tttctggcga tgatacattc gcatgaagca 1066141 gaaataagct gctgcaaaag gtttgatcga tctccgccaa aggcagccag atccgccgcg 1066201 gttaagtcgt gaaagtcttg ttctctaaag gatgtcagtt cagcatcaag cttttttgta 1066261 taaggttgaa aactgtgaca gctgtacttt cgcactgaac ctgccgtatg aaaacctgct 1066321 ttttcataaa gcggcaaacc ttcttttgtg gcgcaaagcc tgatggcggt gttttcatcc 1066381 gtttgggtaa tacaggcgtt taccatacgc cggccaagac cgagccgttg atattccttg 1066441 tcaacgataa caaggccgat agaagtaaga cggccaaaca aaaacaagcc gatgcaggaa 1066501 ataatatcac cgctgacatt ttgataaccg aaaaagcgtc cctgctgaac aagcagtttc 1066561 agctcttgtt cgccataatc cggccacccg gcttgcccgc aaagccgcaa taagccggaa 1066621 acgtgttctt catgaagctt aatcagttca tctactacgt ccataagatc acctgcttgt 1066681 tctaagtgtt ttgtacatga caatatgatt gccaatgccg ggaatgtcaa atggttcgcc 1066741 aagttccttc cagccaagct tggcatagta gcccttgaca tggtgtcttg cgttgcacca 1066801 taccgcctga acgccgctct ccgccagttt gtgctccgcg tgtttgatca gcgtgcttcc 1066861 agctttttga tcgcgatatc cctcgagcgt tgccatgcct ctcagccgat acgcagaggc 1066921 ttccgttaat aaaggctgac tttgcgggga aaaagaagcg atgctgatca gcgttccatc 1066981 ataaaacacg ccgagatgaa aggagccttc tgcgtgatcc tctttatatt tgcattgttc 1067041 gatggattga tggggacgca gaatgcgatg ccggatttca tatgtatctt ccacggaaat 1067101 ggttttgact tcgagcataa tgttcctcct catgattgtt tttctatatc gtaacacgaa 1067161 tctcgttgaa aaagactgcc cgattcgatc aggcagtctt ttggaaatta atgcaaaaag 1067221 atattttggc gctgctcatc tttttgctga atatatgatg tgagctcagc ggttaagtca 1067281 gatctgagga aaggcgttat caagtagatg ccgttaaaca gctcgcatgc cgtatccagc 1067341 agggagcgtg caattgcaag gccttccgcc ttttgctttt ctttatcttc accggcatgg 1067401 gccatttttt cgcgaatcgt atcagacagc ttaatgccgg gaatttcatt atggatgaat 1067461 tcggcattcc ggctgcttgt cagcggcatg atgccgatat agatcggcgt cttcagatgt 1067521 tttgtttcgt tatggatatc gacaagctgc tgctcggaat agacaggctg agaaacaaaa 1067581 taatctgcgc cgcaatctat ttttttctca agccgtttta ccgctttatc cagatggcgg 1067641 acgttaggat taaatgcggc ggcaactgag aaattcgttt tcttgccgag cggttttcca 1067701 gacagagaca gaccttcatt gaattgtttg atcagcctga ttaaatcaaa agatgttaaa 1067761 tcatatacag acgtcgcccc aggaaaatcc ccgattttag aagggtcacc tgtaatagca 1067821 agcacgtcat tcagccctaa cgtatcaagg cccattaaat gtgactgtaa gccgataatg 1067881 ttacggtcac ggcacgtaat atggacaagg gaacgcatat cgagctgctg cttgacaagg 1067941 gcgccgcagg caacattgct gatccgcggg gtcgccaaag aattgtcggc gagtgtcagg 1068001 gcatcgattc ccgcttcttt taattcagca gcagcggaca gaaatttgtc aaagcttagt 1068061 tttttcggcg ggtccagctc tacgataata gagcgttttt tcgctgcgat ctcatccagg 1068121 ccgggctcgg ttcgctcgtg atgaacagaa atgaattctt tcgcccgggt tttgacttct 1068181 ttttccgtaa tcggagccag cccgccaacc gcttccgcca tcgccctgat gtgattcggc 1068241 gttgtgccgc agcagccgcc gataatccgc gcaccttgct tacggaattc tgacgcgctg 1068301 ttttgaaaat acgtgtcgtc tgtttcatag acgagccgtc cctcttcaag cgaaggaaga 1068361 ctgctgttcg gataaacgga taagaatacg tcatcaaaaa tcggcacttc gcttagcgct 1068421 tcaatcatgt gataagggcc gaggcggcag ttaatgccga caatatcagc tccgagatcc 1068481 gcaatcgagc gcaatgcgtc agaaagcggc gttccgtcct gcaatacgcc ttgctcgtgc 1068541 atggagacat tgagcataat cggaagatca gtctctttgc gcgcgatttt cagcacttca 1068601 cgggcttctt ccaaatcata atatgtttct aacagcaagc catccggctc ttcatgcagc 1068661 agcagataca gctgctcgcg gaagctgcgc ttaatttcgt caagactgta tgcgttttta 1068721 ttaaatgtgc gtatgccgcc catcgttcca agcacgtatg catcgcctgc tgaagcccgc 1068781 gcgatcttta cggcctcctg attcattttt ttgatgtcat cctcaagccc gtgtctggat 1068841 aatttaatat agttggctcc gtacgtattc gtttgaataa tgttggctcc cgcttcaacg 1068901 tacgctttat gtatgcgctg aatttcctcc ggctttgaaa tattgagctc ctcaaaacac 1068961 ctgtcaatgc cataggagta gaggagcgtc cccatggcgc cgtcaccgat taacacctgt 1069021 ctttgcaaat cttctaaaag tcccattgtc tgcctccttt attcacatca gcaaggaaaa 1069081 aagagaaata aaaaaagtcc tcttaagaag aagactttgt cagtgatttt gtctcttctt 1069141 atcttccaag ctgttcgagc ttgctggatt tagcaccttg gtcatggctg atcgccatta 1069201 caccggttgc tgaagcttcg tcgggccagt ccctctgctt ctcttgataa gaacggatat 1069261 gaaattttcg tgtcaggaag tgccaaaaga tatctggcgt ttttcccttt ctccaaattt 1069321 accgaaaata aagacaataa tcaataggaa tcagaaaatt tatctgaaat ttataaattg 1069381 aacgtcaatt ggcagatctg ctccccgtac agctgagata atctgctgca ggtcatcttt 1069441 gttttttccg gtgacacgca cttgatcatc ctgcacctga gactttactt tcagtccgga 1069501 gtttttgatg atcgtattga ttttttttgc gttgtccttg tcaatgcctt gaacaagctt 1069561 tgcacgctgg cgcaccgttc cgcctgacgc gttttcaacc ttgccgtaat caatgttttt 1069621 tgtcggtacg tttcgtttaa tcaatttgct gaccagcaca tctttcagct ggcttaattt 1069681 gaattcgtca tcggaaacga ggaccagctc ctctttatct aaagaaatgt cgcttttgct 1069741 gcctttaaag tcatatcggg tactgatttc cttcagtgcg atttggattg cgttttgcac 1069801 ttcaggcaat tccaccttgg atacaatatc aaatgaactt tcttttgcca tatgaaaacc 1069861 tccataacat ttaacttatg tgttgattat agtagaataa agagaaactt ccaacagaac 1069921 aaagaatcaa tttgtgatga ttggaaaaaa tgttaacaaa atccgcagag aataagcgga 1069981 acaggaagga cgatagcatg agaccagggc agcaattaac cttgagtata gatcaccaaa 1070041 ccgacttcgg ttacttttta accgatgggg aagatacgat tctcttacat aacagtgaaa 1070101 tgactgagga tatcgaggac agagacgaag tagaagtctt tatatacgta gaccagcagg 1070161 aaaggcttgc ggccacgatg aaaattccga tcatcagcgc ggatgaatat ggctgggttg 1070221 aagtggtgga taaagtggaa gatatgggcg ttttcgttga tgtcggttta tcgaaggacg 1070281 cactagtcgc aactgagcat ttgccgccgt acgaagatgt ctggccgcaa aaaggggaca 1070341 aactttactg tatgctgaag gtgacgaacc gggggcgcat gtttgcgaaa ccagcgccgg 1070401 aagatatcat cagcgaactg tttaccgacg cttcagaaga tctgatgaat aaagagctga 1070461 caggtacggt gtacaggctg atcgcatcgg gttcattcgt gatcacggat gacggtatcc 1070521 gctgttttat tcacccgtca gaaagaaaag aggagccaag actgggttca agagtcacag 1070581 gccgggtgat tcaagtgaaa gaagacggtt cagtcaactt gtcgctgctt ccgagaaaac 1070641 aggatgcaat gtcagttgat gctgagtgca ttctaacgta tatgagaatg agaaacggtg 1070701 ccatgccgta cagtgacaaa agccagcctg acgatatcag agaacgtttt aatatgagca 1070761 aagccgcctt taaacgcgcg ctgggccatt tgatgaaaaa cggaaaagtg tatcaggaaa 1070821 atggatggac atacgagaaa aaatagcatg aaaacggctc gcctgcagca gactgcggag 1070881 cgagccgttt ttttatgtct agtttaattc atcaaccagc gttctgattg ccatttcgcg 1070941 atccacattg tctgaaatcg caatcggcgt aatatcaatg gcgagaatga tcagaatcag 1071001 ggcacctgct gcagcaacat aagaaacata atagaaatag ttagcggtat caacagtgtt 1071061 gacaagctcg gcctgaactc tggatgtatc atccttagaa gcggcgattt cctttgcagc 1071121 ttctactttt tcttcaacga tttgacctgc ttttttcagc agttcatcca ctttcaatgc 1071181 atctttgctg taaacagctt tcttcaggtt atcaaaaaag tcagcatcct cttttttaat 1071241 atcagcgaca acctgattgg caaaagcctt tgcctgtttt gtgttgagtt tgtctgtcat 1071301 cgctttatta aagacctctg gaagctgttt gccaacttcc ccttgggcaa acacaaagcc 1071361 tttaaaaatt tcctcacctg aatactcaag ctgctttgcc tgtgccacac tttcttgctg 1071421 cttcaccaaa aacacagtcg tcaccaatac aaccgacaaa aatactagaa acgccttctt 1071481 caaactgaaa cctctccctt cttgtgtttt ttattccaca acagtctgcg aatatatgta 1071541 aattgaatcg tggaatcgat aggagtgaga tacaatatca aaatgccggc catgataatc 1071601 gaaaaactga tgaggcccag catgactgca aaaatctcat gcataaaaac agcgatgatc 1071661 aaaatcaatc tccaatgctt cttcggcgca aacagtgccg cgaagatgac aatttgaacc 1071721 agcagcgtcc cccatgtcgg aatcaccacg aacggacttg ttacaattgg cttcgttaac 1071781 gcctgaaaaa agccgttgaa gccaatggtt ttttcctggg cgaaataata gacggccgtt 1071841 ccgtccaccc attcctgctg agatagctta gcgacggtag agtgaaaata aagcaccgcc 1071901 acttggattc tgatcacaaa ataagaaata aaagctgtta tttttccaag tgttcttttg 1071961 ccctctatag gtctcgtact ccaatgccat tttctcggat cggtcagcgt gatgggaagc 1072021 aataaaaagg tcatgactgc tgctgcctgc tcgcctccgt cgatgacgat cagcgatgac 1072081 tgcaggctgt aactgacata ccaatgcaga accccggtga ttctggggcg ccagccaatg 1072141 acaacaagca ccagaatggc aatgcagacc catctgaaaa gatttaacat catatagtta 1072201 ttttcgccga gacaaaagag actgagattc attttacaag ctggatagct gctgatcccg 1072261 ctggctggct tcataatgag gctcgggtga ttgatgagca gcgtcagcag gctggatagc 1072321 gcaatgatgc ttcgcgcgag gccatataca tttgtccacg ggtttctttc gtcccatctg 1072381 gtgatggtct gttttatgtt ttcgagcatg agatcacaac cttgactatg ctttttacct 1072441 gataagacga aggggtatat ttagaatagc tccaaggaac aatatcctct ttcgtcaaat 1072501 agtagctgcc acaaagcagc gggcggggag cgggtgtttt taattgcacg gttttggctt 1072561 tgcttttgca tgcgccgagg tccttttctt tacatgctgt ccactgttcc ttgccgactt 1072621 ggctgtagat cacgcccatt tcaacgcctt gtgaccgccc ataccgatac aggccgaata 1072681 ggttgtcagc cctcatattg ggccatctga ccttggcgct ggcattttca gcctcatata 1072741 agccgattgc agtatcacgc ggatttttgc taaaaaagcc ccagccctga gggaggatgc 1072801 tggacatgag aaatttggag tcctttgtca gcggaatcgg ggttgtccct aagctgccaa 1072861 taatagaaaa cagaaatagc gaaccccaaa ggattgaaaa aatgacaaaa aatgatatcg 1072921 atttctgcat tcgactgctc cttttaacct gaagaatcgt ttttacactt ttcataatat 1072981 aaaaacattt atgtaataaa aaggttaaaa agtatgagaa attccatttt tgttaaaagg 1073041 aaaaacagga cattttacac tgctatatgt gattgatata tagtgttttt ttcgatatat 1073101 ttaaaccatg aaaacgaatc aagttaatga ccgctggatt gttcaatttc gaaaagggat 1073161 tttcgagctg gccatcctat cccttctgcg ttctaaaccg atgtacggtt atgagctgac 1073221 gtcatcctta aaaaccacct cggcgctggc tatttcagag ggagcgattt atccgatttt 1073281 gaaacgtatg accgagaagg gatggatcga atttttttgg gaagattcac tggacggccc 1073341 gaaaagaaag tattacaaaa tgacgcaaaa aggagaagaa atgttaaaag aacggctgga 1073401 gaaatacctg gaaacccatc aagccttact gtctttatcg ggggatttgc tatgaatgga 1073461 cagcttatca ttgaccgata catggaggaa ctaaatgcag agctggcgaa tatgcctgat 1073521 gtagagagag aaaacgctat cgacgaatta aaggggcata tcaccgcttt cgttcaagac 1073581 agaatcaaag ccggccttag tgaagaggaa ctgcaggaag ctgttgaatc tgaattttct 1073641 catccgaagg agcttgccga attgatgatg ggtgatgggg gagagacgaa aaggaggagg 1073701 tctttattgg gcaaaagctg gatttcggtc cttctcattg tcacgattat cgccctgccg 1073761 ctgctgccgt ccgacttcag acatctgccg ctggctgttt atttaatggt gctcgccgga 1073821 tatgtatgga agcggaaaaa attggtgatg tttgcaggtg tcagaaaaaa caaaatgcgc 1073881 tctcaaaagg agattgtcaa gatttcgcga gtcggtgcgg tttatctgct gtttttagca 1073941 gtggtgctcc ttttgagccc gttcctcaat gcgcttgtcg tcctgctgct gattgcagta 1074001 agctgcgccg ctttttttct ttttcttaac atcaagtaat cttgtaggag gctgtaagat 1074061 ggaaatcagc atcaattatc tattaattgt catcgcgctt ttattctttg tggttgccta 1074121 ttttgtcgga atcaaaaaac aaacctggat gttggctggg tttaacgagg cgcgtatacg 1074181 ggataaagat cggctggcca gaatagcagg ctactttttc ttgaattccg gtttgttcat 1074241 tttgctgaat agttttatct catttcaagg tcaggagcag ctcatacctc cgcttatact 1074301 ggcatatgga gcaggggtta ttatttatgt caataaaaaa ttagtagagt agaaaaagaa 1074361 gggcagagcg aaatatctct gcccttcttt tttgggaaaa taagaacgaa gcaccacata 1074421 caagtttttg tatttttgat aggatgaaga aaaatggtag attccaaaat aggaaggatg 1074481 tggtgttttg cgcaacttga ccaagacatc tctattactg gccggcttat gcacagcggc 1074541 ccaaatggtt tttgtaacac atgcctcagc tgaagaaagc atcgaatacg accatacgta 1074601 tcaaacccct tcatacatca tcgaaaagtc accgcagaag ccggtacaaa acacaaccca 1074661 gaaagaatcg ctattttcct atcttgacaa gcatcaaacg cagtttaagc tcaaagggaa 1074721 tgcgaacagc cattttcgcg tttcgaaaac cataaaggat ccaaagacaa aacaaacgtt 1074781 ttttaaatta acggaggttt acaaaggaat tccgatttac ggctttgaac aagcggtcgc 1074841 gatgaaggaa aacaaacaag tgaaaagttt ctttggaaag gtgcatccgc aaatcaagga 1074901 cgtctccgtc acaccgtcta tttctgagaa aaaagcaata catacagcaa ggcgtgagct 1074961 cgaggcttcc attggaaaaa tcgaatatct tgatggggaa ccaaaaggcg aattatatat 1075021 ctatccacac gacggtgaat atgatctcgc ctaccttgtg agactctcga catctgaacc 1075081 tgagcctggc tattggcatt atttcatcga tgccaaaaac ggaaaggtca tcgagtcctt 1075141 taatgccatt catgaagcgg caggtacagg aatcggcgtg tcaggtgatg aaaaaagctt 1075201 tgacgtcaca gaacaaaatg ggcgctttta tttggctgac gaaacaaggg gaaaagggat 1075261 caatacattt gacgcgaaga acctgaacga aaccttgttt acgcttttgt ctcaactgat 1075321 cgggtatacg ggcaaagaaa tagtcagcgg cacgtccgta tttaatgaac ctgcggctgt 1075381 agacgcacac gcaaatgcgc aagccgttta cgattattac agcaagacat ttggccgtga 1075441 ttcttttgat caaaacggag caaggattac gtctaccgtg catgtcggca aacaatggaa 1075501 caatgctgcg tggaacggtg tccagatggt atacggggat ggagacggtt cgaaatttaa 1075561 gccgctgtct ggatcgctcg acattgtcgc gcatgaaatc acacacgcag tcacacagta 1075621 ttccgccggt cttttatatc aaggagaacc cggtgcatta aatgagtcca tttctgacat 1075681 tatgggcgcg atggctgacc gtgatgattg ggagatcggc gaagatgtct atactcctgg 1075741 tattgcagga gattcattgc ggtcattgga ggacccatct aagcagggaa atccagatca 1075801 ttactcgaac cgctacacag gaacagagga ttatggcgga gtccatatca attcgtccat 1075861 tcacaataaa gcagcttatc ttcttgcaga aggaggcgtg caccacggtg tacaggttga 1075921 agggattggg cgtgaagcaa gtgaacaaat ttactatcgg gctttaacat attatgtaac 1075981 ggcatctaca gatttcagca tgatgaagca agcggcgatt gaagctgcca atgatttata 1076041 cggtgaaggc tcgaagcaat cagcttcagt cgaaaaggcg tatgaggctg tcggcattct 1076101 atgagcaaac aaaaacagtc aggacacaga gtctgactgt ttttgtttgc tcattttctt 1076161 aaaaagaata tcgccaatgt acctggaccg gcatgcgagc cgatggctga actgattgga 1076221 tgcataatga tttctttcgg cttgaacgct tcctcaatca ggtgtttcat atccgtggct 1076281 ttttctttgt tcgcggcgta gctaatcccg acggtttgat tgctccaatc atccccgcgc 1076341 tctttcataa gctcgatgat ccgtttgaaa agtttcttct gtccgcgaat tttttccaga 1076401 ggcacaagct tgccgtcctc catctgaagc agcggtttaa tattcaacag gccgccgaca 1076461 aaagcggacg ttttggatat ccggccgccc ctcgcgagat atgttaaatc atcaacggta 1076521 aaaatgtgtt caagctggct gcaaaagttc tttacagacg tttcaatttc ttgtattgta 1076581 ttcccgttga tacagagatc ggcagcatgc cggacagcca gaccgtatcc taatgaagcg 1076641 catttggaat caatgacccg caaatcgaaa tcggggaatt cctccttcac ttcattggcg 1076701 atcattacag ctgtctgata cgtgccggag agacctgagg aaaaggcaat gtaaagagcg 1076761 ggatcacctg tttcggcata ttgcaaaaac acatttttaa tcgtttgcgg tgaggcttgg 1076821 gacgtcttag gcgtttctcc attttgcatc gcttcaaata tttgatccgc atgaattgtg 1076881 actgcatctt cgaattcttt atcgccgaga gaaaccctga gcggaataaa gccaatgcct 1076941 ttttcttcaa aataagaacg aggcaaatca gtggcgctgt cagcgatgag atgaactgtc 1077001 atattgcttc ccttctttcc gttatcgctc gttatcatga gagttaagcc aactatatca 1077061 tattaatttg ccaaaatcgt gttcaaatat ttgttttaag ggaaaacata ataaagaaga 1077121 aagagcggag gaacatgcca tggtactaga tcaaacaaaa aaattactca tcgtcatcat 1077181 cggcgcttta ctcaatgctg ccgggctgaa cttatttttg atacctgcag atgtatatgc 1077241 cagcggattt acaggtgttg cccagctttt atcaagcgtc gttgatcaat atgccccctt 1077301 ttacatatcg acgggaacgc tcttgttcct cttaaacatt ccggtcggta ttttaggatg 1077361 gctgaaggtc ggcaaatcgt ttacagtgta cagcatttta agtgtcgcac tcactactct 1077421 gtttatgggg atcctgccgg aaacaagcct gtcacatgac attttgctga acgcggtgtt 1077481 cggcggcgtc atttccgcag tcggtatcgg cttaacatta aaatacggag cttcgacagg 1077541 cgggcttgat atcgtcgcca tggtacttgc aaagtggaag gataaacccg tcggcacgta 1077601 tttcttcatt ctgaacggga ttatcatctt gacggcagga ttattgcaag gttgggagaa 1077661 agcattatat accctggtta cactatatgt gacaacgagg gtgatcgacg ccattcacac 1077721 tcgccacatg aagcttacgg caatgattgt gacgaaaaaa gcggacgaaa tcaaggaagc 1077781 catttacgga aaaatggtgc gcggcatcac aactgttccg gcaaaaggag catttacgaa 1077841 cgaacagaaa gaaatgatga ttatcgtcat cacgaggtat gaactgtacg atttagaaaa 1077901 gatcgtcaaa gaagttgatc caaaagcatt tacgaacatc gttcaaacga cagggatttt 1077961 tggtttcttt agaaaagact gacgaaagca ggtggaagtc gtgaaacggc tgcttgtgat 1078021 gctcctcccc gtgctgcttt tgataggctg cgggaaagat gagcagacag aacccgataa 1078081 ggaggtatca ggcggaatgg agaatcaaga ggttgtttta tctattgacg caattcagga 1078141 gcctgaacaa atcaagttta acatgtcgct gaagaaccaa agcgaacgtg ctattgagtt 1078201 tcaattcagc acagggcaaa aatttgaact tgtcgtgtat gattctgagc acaaagaaag 1078261 ataccgttat tcgaaagaaa aaatgtttac gcaggctttt caaaacctga cgcttgaatc 1078321 tggagaaaca tatgatttct ctgatgtgtg gaaggaagtc cctgagcccg gaacctatga 1078381 ggtaaaggtg acatttaagg gcagggcgga aaatctcaag caggttcagg ctgttcagca 1078441 gtttgaagtc aaataagagg ctatggcgag tcgccatagc ctttttttat tgcagtttgt 1078501 ccagctgatt ttgaaattga tgcaactgtt gacgttccgc atctgtcgaa ttggcatacg 1078561 cagaagatac agcatttttg gctctcagaa tcgcttgctc ctgatcgcct tcctcaaagc 1078621 cgtttgtcac catgaccgcc tgttgaacaa atgattttgc ctgctgaaac agttcatttc 1078681 tcatttaata ttcatactgc ctttcagccg agtctcgtgc cgcggcatgc tggtgagctt 1078741 cttctaaagt agaccgatat ggaaatcttg cggcgtgtag cccgatggag tctttaccct 1078801 gctgaataaa ccttctggat ttgcttcgtt tacccatttt gagactgccc ccttccatac 1078861 tttgacgaga tgagtcgtct tcaatagtat ggtggggtaa agtaaggttt atgagtggga 1078921 aaaattaata cggaccttct ttaaagtgag aaatattctt tcaaaaacct tgccacgccg 1078981 tcctcttcat ttgtggccgt agttcggttg gcaatctgct tgaccgcgtc aattccattt 1079041 cccattgcaa cgccgcagcc tgcaaattca agcatttcca aatcgttatc ctcatctcca 1079101 aaagcaatga tccgctccct cggcacgccg taataatcgc tgattttctg caggccgacc 1079161 gctttattca tgccgctttt gataatttca atgacatgcc aaggagcggc ccatcttcta 1079221 tggtcgatca cctcggcatg cacatccgat aaatatgagc gtattgccgg cacatcctct 1079281 tcctttgcat gtatgagtac ggacgtcaca tcttcaccga gattttcccg caagtctccg 1079341 accgttacat ttgttgtgtt catgttaaag gcatctatca ggtgctcatc atggtaatga 1079401 aagtatacgt cgtcaatcac ttcagcaagc acgttatgta cgttgtagct ctcgctgata 1079461 tccacgagct gtttgacaac atcaagcggc agtgacgtat gataccgtcc ccagctgtcg 1079521 tcttgcggat gatggacaaa tgctccgtta aaattgacaa ttggcgttgt cagctccatc 1079581 tgctggtagt acatggaact tgaacgatac ggacggcctg ttgagatgca gacataatgc 1079641 ccgtcatctt ttaggcgctg tatcgtatga agggtgtttt cagatatggt tttatcatcc 1079701 tttaataatg ttccatctaa atctaatgcg attaaatagg gttttgtctc catgaaaagc 1079761 tcctttaacc ttagattttg cttgttttgc cttacttaca gtgtagcttt ttaccatctt 1079821 tattgtctac atgttacact tatgattatg gttatcctaa ggaggggcac attgtgatac 1079881 aaattgagaa tcaaaccgtt tccggtattc cgtttttaca tattgtaaag gaagagaaca 1079941 ggcaccgcgc tgttcctctc gtgatcttta tacatggttt tacaagcgcg aaggaacaca 1080001 accttcatat tgcttatctg cttgcggaga agggttttag agccgttctg ccggaggctt 1080061 tgcaccatgg ggaacgggga gaagaaatgg ctgttgaaga gctggcgggg catttttggg 1080121 atatcgtcct caacgagatt gaagagatcg gcgtacttaa aaaccatttt gaaaaagagg 1080181 gcctgataga cggcggccgc atcggtctcg caggcacgtc aatgggcggc atcacaacgc 1080241 ttggcgcttt gactgcatat gattggataa aagccggcgt cagcctgatg ggaagcccga 1080301 attacgtgga gctgtttcag cagcagattg accatattca atctcagggc attgaaatcg 1080361 atgtgccgga agagaaggta cagcagctga tgaaacgtct cgagttgcgg gatctcagcc 1080421 ttcagccgga gaaactgcaa cagcgcccgc ttttattttg gcacggcgca aaagataaag 1080481 ttgtgcctta cgcgccgacc cggaaatttt atgacacgat taaatcccat tacagcgagc 1080541 agccggaacg cctgcaattt atcggagatg aaaacgctga ccataaagtc ccgcgggcag 1080601 ctgtgttaaa aacgattgaa tggtttgaaa cgtacttata aagcactaag ttattaacaa 1080661 gagctgaatt tacgttatac tgtagaaaaa aggagtgagg gaacgtggaa gaagcattaa 1080721 aagaaaacat catgggcgcc ctggaacagg ttgtcgatcc tgagcttggc gttgatatcg 1080781 tgaacctcgg cttggtatat gacgttgata tggatgaaga tggcttgacg cacatcacca 1080841 tgacgctaac atcaatggga tgccctttag cgccgattat cgtggatgag gtgaaaaaag 1080901 cattagcgga ccttcctgaa gtgaaagaca cagaggttca cattgtatgg aatccgcctt 1080961 ggactaggga taaaatgtcc agatacgcaa aaattgcgct tggcattcaa taaaacaaaa 1081021 aaggacagcc tgacatgtga ggctgtcctt ttttacagct gaaaggagtg aaaggaaatg 1081081 atgtacctgc tggcagtttt atgcccgccg cttgctgttt tgttttcggg aaaaccgttt 1081141 caggccttgc tgaatctcat attgacctgt atcttttggc tgccgggcgc gattcacgcc 1081201 tgctttatcg tcgccgaccg ccgtgccgaa aaacgggcaa gaagataatt tggaaaaatg 1081261 aggacgcagt catggtataa tggtcataaa aacagcaggg agagcactat gaaaaagaaa 1081321 ttgcttgcat tcgcgctttg tactggcgcg tatgcggccc tgtttgcgta ctctgtgaac 1081381 tcagagcaaa aaacagccac aagcgagatg acggatgtca gccgcctgat gcctgtaaaa 1081441 ataaagcaga cagtgaaagg gcaggaagag gaaatgctca ttgacacagt caaagaggca 1081501 aatcgaaaaa acataaaaat ttcaatcgcc ggggcccagc actccatggg cggccataca 1081561 tattatgagg acggcatcgt tctcgacatg acgggctaca acaaaatcct gtcactcgat 1081621 caagagaaga aaaccatcag ggtgcaaagc ggtgcaacgt ggaatgatat ccagaaatac 1081681 gtgaatccat acggactcgc ggtaaaagtc atgcagtcac aaaacatttt tacaatcggc 1081741 ggatctctca gcgcaaatgc acacggacgt gatattcgct acggctcgct aattgataca 1081801 gtcaaatcat tccggctttt aaaagctgac gggatgatta tcactgtcac tccaaaagat 1081861 gatttgttta cggcggtcat cggagggtac ggcctttttg gcgtgattct tgatgtaacg 1081921 cttgagctga cagatgatga gctgtatgtc atgaagacag aaaaaatgaa ttacagcaca 1081981 tactcagact atttttcaaa gcatgtaaaa ggaaatccag atgtccgaat gcatctggcg 1082041 cgaatttcaa cagcgaaaaa aggatttctg aaagacatgt atgtcacgaa ttacgtattg 1082101 gctaatcatc aggatcagct gtcctcatac agcgaactta aagaagacga gtatacggga 1082161 gccacaaagt ttgcactcgg cttgtcaaga cggtatgaat gggggaggaa ttggctgtgg 1082221 gacacacagc aatcctattt cctgagccag aacggcacag agatttcacg caataacgtc 1082281 atgcggtccg aatcaaagtt tcttgagtat gaaaacaatg acaacacaga tgttttgcaa 1082341 gaatactttg tgcccgtgaa ggagtatggg tcctatattg atgacctgag acaaacgctg 1082401 tcggacgaag atctgaacct gctgaacatt acgatccgct acgtgcagaa aaatgaaaag 1082461 gccgaccttt cctatgcgaa ggacgatatg ttttcgctcg tactattaat aaacgagggc 1082521 ttttcaaaag aagaccaggc agataccgcc cgaatcatca ggcgcatgac agacgttgcc 1082581 atcaagcacg gcggcagcta ttatctgcct tatatgacct accagacaaa agcgcaaatg 1082641 agacaggcat atccgaaaag tgaagcgttt tttcagaaaa aacgaaccta tgacccggat 1082701 gagcgcttta tgaattactt ttatcagagg tataaataat ggggaaaaac aaattaaaat 1082761 ggctgacatt atcacaaagc agcgtgtttt tcgcaagcag cttaatcttt ccgttttata 1082821 ttctgtttgt gaaaaatatc ggctcaagct acacacagtt cggtttttcc tacggattgt 1082881 tcgggttgag cggagcgctt atttacccgc tcctcggacg gctgtctgaa aggtttgaca 1082941 gccgttattt tctgcttctg aactcgtggg ggatggctgt tctgctttta tatgtcccgc 1083001 atatcggaag cgtcgttcaa gtgtatatcg tccaagtgct gttagggctc tttggagcga 1083061 tgcaaaagca tggagaaaaa gtgctgatcg ctaattttac agacagtgga gagcgtggaa 1083121 agaagatcgg gaattaccat ttttggacag ctgtcttttc agcagcagcc attatgctcg 1083181 ggggctttct cgctgacttt ttcacagtgc aaatgatttt ttatgcaagc tctattctat 1083241 attttttgag tggattgatg atgatgaaaa caggctgacg cggtcagcct gtttttttat 1083301 gcggctgaaa tgcggcaccg catcaacgtt tttgtgctgg agtcgtgctg attttttttg 1083361 agcggaattc ccattgaaca gaaaatttat aaatgaataa aaatattaaa tatacgattg 1083421 aattaatttt tattcatgtt ataatgttaa ataatttcac aaagaccaag agggtgaact 1083481 tgttttgaaa ataggaattg taggtgctac aggatatgga ggcaccgaac ttgtcaggat 1083541 tctttcgcat catcctcatg cagaggaatg catactttat tcatccagcg gagaagggaa 1083601 tgtctatagc gagggttatc ctcatcttac cggcttagcg gatcagcagc tgaagccgat 1083661 tgatatgaat acgatcaaac acgaaataga tatcatgttt ctcgctgcgc cgcccggagt 1083721 atcaagtgaa ttgactccaa agctggcaga cgcgggaatt acggttattg atctgtcagg 1083781 tgatctgagg ataaaagaac cggctgaata tgaaaaatgg tataaacgga cagcggcacc 1083841 gaaggcggtg attcaagagg cggtatacgg tctggcagaa ctgaatcaac tgcaaattca 1083901 acaggcgaaa ctcattgcca atccaggctg ttttccaaca gctgttttgc ttggcctcgc 1083961 gccattggct caaaagaaac tgctcgatga atctttcgtt atcgttgacg cgaagaccgg 1084021 tgtttccgga gcgggaagaa aagcatccat gggaactcat ttttctgagc tgaacgacaa 1084081 ttttaaaatt tataaagtca atgaacatca gcacacgccg gaaattgagc aggcgctgaa 1084141 tgaatggcag ccaggtctcg ggcccattac attttcggct cacttggttc cgatgacaag 1084201 gggcatcatg gcgacgatgt ataccagatt aacctgtgac ctaaccgcag atgacctgca 1084261 tgatttatat tcggaatttt accaagattc atattttgtg agagtgaggc caaaaggtca 1084321 gtacccgcaa acgaaagaag tgtacggcag caatttctgt gatatcgccg tgaccctcga 1084381 tgagagaacg aacagagtca cgatcgtctc ggtaatcgat aatttaatga agggtgccgc 1084441 cggtcaggca gtgcaaaact ttaatttgat gaatggctgg aatgaagaaa ctggactcac 1084501 catcacgcca atttatccat agaacgggag agaatcgaac catgattcag ttaagtgaag 1084561 atcaaattgt aaaagtaaca ggtgatgtat cctcgccaaa agggtttcag gcaaagggtg 1084621 tgcattgcgg actgcgctac tcgaaaaaag acctcggcgt cattatcagc gagacaccgg 1084681 ccgtgagtgc agcagtttat acccaaagcc actttcaggc tgctccgatc aaagtgacac 1084741 aagacagctt aaagcacgga ccgacactga aagccgtcat cgtcaacagc gccattgcca 1084801 acgcctgcac gggagaacag ggcttaaagg acgcatacac aatgcgggag agctttgctt 1084861 cacagcttgg cattgagccg gagcttgtcg ctgtttcatc aacgggtgtc atcggcgagc 1084921 atttagacat ggaaaaaatc cacgcgggga tcgaactgct gaaagaaaca cctgcgggat 1084981 caggcgattt tgaggaagcg attttaacaa ctgatacggt gatcaagcag acgtgctatg 1085041 aactggcaat cggcggcaaa acagtcacga tcggcggagc ggccaaaggc tctgggatga 1085101 tacacccgaa catggccacg atgctgggat ttgtgacaac tgacgcggca atcgaagaaa 1085161 aagcgctgca aaaggcgctt cgggaaatca ctgacgtttc atttaaccaa atcacagttg 1085221 acggagaaac atccacgaac gacatggtat tagttatggc gaatggctgc gccgaaaacg 1085281 agtgcctgac agaagaccat ccagactggc cggtctttaa aaaagcgctc ttgctcactt 1085341 gtgaggatct agctaaagag attgccagag acggagaagg cgcgacaaaa ctaattgaag 1085401 cccaagtaca gggagcgaaa aacaatcttg atgcaaacgt cattgccaaa aagattgtcg 1085461 gctcaaatct tgtaaaaacg gcagtatacg gaacagatgc caactggggg cggatcatcg 1085521 gagccatcgg acactccgca gcacaggtga cggcagaaga agtagaggtt tatcttggcg 1085581 gccaatgcct gtttaagaat aacgaacctc agccattctc tgaatctatc gccaaggaat 1085641 accttgaagg agatgaaatc accattgtca tcaagatggc tgaaggggac ggaaacggga 1085701 gagcgtgggg ctgtgacctg acctatgact atatcaaaat taacgcgagc tatcgcacgt 1085761 aataaagggg agcgaaatga agaaaacaat cgtttttaaa tgcgggggaa gcgtcatccg 1085821 tgagctgtcg gaggaatttt atcaaaatct gaaagagctg agggcgtcag gctggaagct 1085881 ggcaatcgta catggcgggg gaccggaaat cacaaatatg ctgaaacggt taaatatcaa 1085941 gacagagttt tcgggcggac agaggaaaac aacgaagccg gtgctggaag tggcggaaat 1086001 ggttttatcc ggttctgtca ataaattttt cgttgctgag cttgccaaac acggactgcg 1086061 agccgcgggc atttctggta aggatggcgg tcttttggag gctgattatc tagatccgga 1086121 aacatacgga gaagtgggag aaatcaaaaa agtcgatgcg tccatggtga acgcgctgat 1086181 ggaaaatggc atcatccccg ttattgcgcc gctgtctatg acaagcgact gcaaaacgct 1086241 gaatgtaaat gctgatctgg ctgcttcagc agtcgccgga gcgcttgaag ccgataagct 1086301 gatgttcgtc acggatgtcg atggaatcat gaaggaaaag cagcgtctgg acgtcctgac 1086361 ccctaaggag attcagatgc tgatcaagca ggaagtgatc acaggaggga tgatcccgaa 1086421 ggtcaattca gccttgtcag ctttatcaga tcaggtgtct gaagtcatga tcgtaaacgg 1086481 taaaggatca ttcttcgcag aacaaacctt tcaagggaca aaaattgtca aagcaaagga 1086541 ggctgtttca tgagcagctt gtttcaaacc tacggccgtt gggatattga catcaaaaaa 1086601 gcaaagggaa cgtacgttga ggatcaaaac ggcaaaacgt accttgattt cattcagggg 1086661 attgcggtat caaatctagg acactgccat gaagcggtga cagaggcagt caaaaaacag 1086721 cttgacagcg tatggcacgt atccaacctg tttcaaaaca gtctccaaga gcaagcggcg 1086781 cagaagctgg cagcgcatag tgcgggagat cttgtctttt tctgcaacag cggcgcggag 1086841 gcgaatgaag gtgcgataaa gcttgccaga aaagcaactg gaaaaacaaa aatcatcact 1086901 tttcttcagt cgttccatgg ccgcacgtat gcagggatgg ctgcgaccgg acaggataaa 1086961 atcaaaacag gcttcggccc gatgcttgga ggctttcact acctgccata caatgatcct 1087021 tctgctttta aagctcttgg ggaggaaggc gatattgccg cggtgatgct tgaaacagtg 1087081 cagggagaag gaggagtcaa tccggcgagt gctgaatttt tatcagccgt acagtcgttt 1087141 tgcaaggaaa agcaagccct tctcattatt gatgaaatcc agaccggcat cggacggacg 1087201 ggaaaaggct tcgcatatga gcacttcgga ctctcaccgg atatcatcac agtcgccaaa 1087261 ggattgggaa acggctttcc ggtcggcgct gtcatcggaa agaaacagct tggagaagcg 1087321 tttacccctg gttctcacgg aacgactttc ggaggaaaca tgctggcgat ggctgctgtg 1087381 aatgccacat tgcaaattgt attccagcct gactttttgc aagaggctgc tgacaaaggg 1087441 gcgtttttaa aagaacagct tgaggcagag ctaaagagcc cttttgttaa acaaatccga 1087501 ggtaaaggat taatgcttgg aattgagtgt gatggcccgg ttgctgacat tattgctgaa 1087561 ttgcagacat taggcttgct tgtattgccg gccggcccga acgtgattcg gctgctgccg 1087621 ccgctcaccg tgactaagga tgaaatagca gaagccgtca gcaagctgaa acaggcaatc 1087681 gctcatcatt ccgctgtaaa ccagtgattt tttttcgata taaaggcata aaaattcatt 1087741 tttataatta attattcatc aagaggtggg ctgttagatg gaaggttatt tagtgttaga 1087801 agatgggaca tcgttcagcg gcgagctgga cggtcatgaa aactgcacgg gagaagctgt 1087861 ttttttcaca ggaatgacag gctaccagga agtgctgaca gatccatcat ataagggaca 1087921 gattattgta tttacctacc cgctgattgg caactacggc ataaatgaaa aggattttga 1087981 aagcaagaaa ccgcaagtaa aagccgcggt tgtctatgag gcgtgtgatc acttttctca 1088041 ttatgaagcg gtatacagcc tcaaggagta tctacagaaa tggaatattc cgctgttaac 1088101 ccatgttgat acgagggctg tcgtgaagaa aatccgggca aacgggacga tgggtgcgac 1088161 agtcacagcc tctaaagaag gagctgagat tgcccttcaa ccagagaatg tggcagagca 1088221 ggcttccgcc caggaaatca gcacattcgg cgacgggaat aaacatatcg ctctcattga 1088281 ttttggctat aaaaagtcaa tcgcatcatc acttgtcaaa cgaggctgca aggttaccgt 1088341 ggtgccatac cagcaaatgg aggccgtata caacatcaaa cccgatgggc tatcgaacgg 1088401 acctggagat ccgaaagcca ttcagccata tttaggaaag atcaaaagca tcatcagccg 1088461 ctttccgact ctaggcattt gtctcggaca tcagctgatc gcgctcgcgt ttggagggaa 1088521 tacttttaag ctgccattcg ggcacagggg agctaatcat ccggtcatcg accgtaagac 1088581 gaaacgggtc tttatgacaa gccaaaacca cagctatgtg gttgatgaac agtcgattaa 1088641 tgaagaagag ctcaccatca ggtttcatca tgtcaatgat acgtcagttg aagggcttgc 1088701 ccataaaaaa ctgcctgtca tgagtgttca attccacccg gaagcccatc ccggacctgc 1088761 ggaaagcgaa tggatttttg atgattatct aaagaatgtg ataccagcaa ggagagaaat 1088821 cgcgcatgcc taaagacacc agtatttcaa gcatattagt aattggctca ggcccgatca 1088881 tcatcgggca ggcggcagaa tttgattatt caggcactca agggtgcatc gcgctgaagg 1088941 aggagggcta ccgggtaatt ctcgtcaaca gcaatccggc gacaattatg actgatgaag 1089001 ccttcgctga tgaaatttat tttgagcctc tgacagcaga aagcctgaca gccatcatta 1089061 agaaagaacg gcctgatggg cttcttgcca atttaggcgg tcagaccgcg ttgaatttag 1089121 cggtggagct tgaagaaacg ggtgttttaa aagagcacgg cgtcaaactc ctcggcacat 1089181 ccgttgaaac gatacaaaaa ggagaggacc gggaaaaatt ccgttcgtta atgaatgaat 1089241 taaaacagcc tgtgccggag agtgaaattg ttgataacga ggccgatgcc ctccattttg 1089301 cggaatccat cggttttcct gttattatca gaccagctta cacattaggc ggaaagggcg 1089361 gaggaatcgc ccctgataaa gaagccttta cagctatgat taagcaggcg ctattagcaa 1089421 gcccgatcaa tcaatgcctt gtcgaaaaaa gcattgccgg ctttaaagaa attgaatatg 1089481 aagtcatgcg tgacagcaat aacacatgca ttaccgtctg caatatggaa aatatcgatc 1089541 cggtcggcgt gcatacaggt gactctatcg ttgtggcgcc gtcacaaaca ttgacagacg 1089601 aagactatca aatgctgcgg acagcaagtc tgacgatcat ctcagcactt gatgttgtag 1089661 gcggctgcaa cattcaattc gcgcttgatc cattcagcaa gcaatattac gtcattgaag 1089721 tgaatccgcg tgtaagccgg tcatcggctc tcgcatctaa agcgaccggt tatccgattg 1089781 cgaagatggc cgcgaaactg gcagtcggat acactcttga cgagctgaaa aatccgctca 1089841 caggctcgac ttacgcaagc tttgaaccgg cactggatta tgtgatcgtc aaatttccgc 1089901 gctggccgtt tgataaattc aaaaacgcag accgcaagct tggcacaaaa atgaaagcca 1089961 ccggtgaagt gatggcgatt gaacggaatt tagaagcggc gatacaaaag gcagccgcgt 1090021 cgcttgaatt aaaaaatatc gggacacacc ttccagagct cagcgggttg tcaattgata 1090081 cgctatggga tttggcaatc actccggatg accgcagatt tttcgttgtc atggagctgt 1090141 tgagccgcag cgtctcgatt gatgacatcc atgaaaaaac aaaaattgat ccgtttttcc 1090201 ttcatacctt tgacaacatc atcaaattgg aaaaccgcct gatggaagca gggagcgatc 1090261 tctcttttga attattgaag aaagcaaagg aaaagggatt ctcagacgca acgattgcct 1090321 cgctgatcag caaaacagaa gaagaggtgc gcgcgcttcg caaggagatg ggcattacgc 1090381 cttcctttaa aatcgtagat acatgcgcgg cagagtttga tgcgaaaaca aactattttt 1090441 actccacata tttcggagag accgatggag acatcagccg caaagagaaa aaacgcgcgc 1090501 tcattatcgg atcaggcccg attcggatcg gccaaggcgt tgaatttgat tacagtgctg 1090561 ttcacggtgt gctgacactg caagagcttg ggttcgaaac catcatgatt aacaataacc 1090621 cggaaactgt cagcaccgat tatgaaattg cggaccgcct gtattttgaa ccgatgacaa 1090681 cggagcatat tgtaaacgtg gcggagcagg aaaatattga ttttgcaatt gtgcaatttg 1090741 gcggtcaaac tgcaatcaat gctgctgaag cgctcgaaaa agccggcatt actcttcttg 1090801 gcacatcatt tcaaacgctc gacgtgttag aggatcggga tcaattttat cagcttcttg 1090861 acgagctggg attgaagcac gcaaaaggag aaattgctta tacaaaagaa gaagccgctt 1090921 caaaagcgag tgagatcggc tatccggtgt taatccgccc atcttacgtt atcggcggaa 1090981 tgggcatgat cattgttgac tcgcaagccc agctttctca gctgctgaat gatgaggaca 1091041 gcatgccata cccgatttta attgatcagt atgtgtctgg aaaggaagtc gaaattgatt 1091101 tgatttccga cggcgaggaa gtctttatcc cgacatatac cgagcatatt gaacgggcag 1091161 gtgtccattc aggggacagt tttgccattc ttcccggacc gtccatcacg agcgggctgc 1091221 agcagggcat gaaagatgcg gcacaaaaaa ttgcccgaaa actttcattt aaaggcatca 1091281 tgaacattca atttgtgatc gacaatggaa acatactcgt tcttgaagtg aatccgagag 1091341 cgagccgcac ggttcctgtc gtcagcaaag taatgggcgt tccgatgatt ccgctcgcca 1091401 cacgtctgct ggcgggagcg tccttaaaag atctaaatcc ggcagttcaa aatcatcatg 1091461 gagttgccgt gaagttccct gttttttctt ctcatgcgat ccaggatgtg gatgtcaagc 1091521 ttggaccgga aatgaaatca acgggagaag gcatgtgtgt cgcatatgat tctaacagcg 1091581 ccttgaaaaa aatctataca agagtctgga gtcaaaaagg aagcatttat ttgcaaaacg 1091641 ttccggaaga tgtgaaggag ttagcagaaa acgcaggttt tacaatacat gaaggaacat 1091701 ttgcctcatg gatggaacag gaaggaaact cgctccacat taatctgagc ggttctgaag 1091761 aagcacgcaa agaacgtttg gaagccatga cgcacggcat ccccgtcttt acagaagaag 1091821 aaactgtgcg ggcgttttta caaagcggtt caggccatcc gcagcctgta tctctcaaag 1091881 acctctataa aaaggaagtg gcatcatgca cacagtgacg caaaccagtt tatacggaaa 1091941 agatttatta acgttaaagg accttagtga agaagatata aacgccttgc tcgcagaagc 1092001 cggtgagctg aaacaaaaca aaattcagcc tatattccat ggcaaaacct tggcgatgat 1092061 ttttgaaaaa tcatcaacgc ggacccgtgt ttcatttgaa gcgggcatgg cgcagctggg 1092121 cgggagcgcc ctctttctaa gccagaaaga tctgcagctg gggcgcggtg agactgtcgc 1092181 tgatacggca aaagtgctgt caggctatgt ggatgccatc atgatccgga cctttgaaca 1092241 tgaaaaggtg gaggaacttg ccaaagaagc tgacattccg gtgatcaatg gacttaccga 1092301 taaataccac ccatgccagg cgctggcgga tctcttgacg attaaggaga taaaagggaa 1092361 gcttaaaggc gtaaaagtcg cgtacatcgg tgacggaaat aacgtggcgc actccttgat 1092421 gatcggctgc gcgaaaatgg gctgtgatat ctcgatcgct tcaccaaagg gatatgaagt 1092481 gttagatgaa gcagctgaag cggcaaagac atatgcactt caatccggct cttctgtcac 1092541 gctgacagat gatccgattg aagctgtaaa agacgcggac gtgatttatt ctgatgtgtt 1092601 tacaagcatg gggcaggaag cggaagagca agaacgtctt gctgtctttg cgccttatca 1092661 ggtgaatgcg gcgctggtca gccatgccaa gcctgactat acatttttac attgtctccc 1092721 tgcgcatcgc gaggaagaag tgactgcgga gattattgac gggccgaact ctgcagtgtt 1092781 ccagcaggcg gaaaaccgtc ttcatgtgca aaaagcactg ctgaaggcca ttttatataa 1092841 aggggaatca tcaaaaaact gctgagccaa actcagcagt ttttttgatg gcaacatatt 1092901 cacagccgct taggcgcata ctacagcaaa aaggaaaagg aggaaaaaca gtgggacagc 1092961 agcaccaatt ccggcccgga cagaaagcgc ctaataacgg tgtctacgta gaaatcggcg 1093021 agacagggag catggttaaa aaccctcaaa aggtccatct gtcagcaggg gaaatgttcc 1093081 ccgaaacatc aaaccacaac cggctgtgga cctacaaaag aaagccgtga ccactaaaaa 1093141 acccaaaaca ataaatgttt tgggtttttg gctttttaat gctggcttgc atttttgttc 1093201 ataggcatga tttctgctaa aaccatgatt aagacataca gtacaacagc aatgacagat 1093261 gatgttttga aattatacgt aacgctgttc atgcttgcaa ccaagtagca tgccatatgt 1093321 gataaaagga acgtccaaat aaaggcaata atatatcgca cgtttccacc tcgtccttct 1093381 cattctattc taaaagttat cataccatac aaaaagcgaa gggggaatcc aattttagca 1093441 gaaagtgagg tgacaaaaga gtctgattcg tcacacttta atggtaaaat ataaaacgtc 1093501 aatcagtata atagccaaaa atgtaaaagg ctaggacttt accttattcg tttcttttct 1093561 atttacataa gatagcgtga gatgaagtgt gaaaggaggc gggcaagcga tgggaataac 1093621 ggaaagatac tttcaactgg gaacggagca taatgtcatt catctgccct atcgcccgaa 1093681 cggcttcggc atctttatct tgggggacag aacccacttt gtcggacatg attcaagctt 1093741 ttggcagcag cattatggca gaaatcagct tctgagcatg ttgatgaatg aaggatacac 1093801 tctttttaac agcaatctgt tcggaaggca ttggggggcg gaaaaagcag tcacctatgc 1093861 caaacagctg atacattctg tgctgaagca ggaaatcctc aatccgaaga ttcatatttt 1093921 agcagaaggc atgggtgctc tcgtggccga tgaactgctt cgtttttccc cggatcatat 1093981 ccgctcagcc gcaatgttga atccttgtct cgatcttcag gcacattatg aatcggaaaa 1094041 agaaaataaa tttttctata agcaattttt gaaagaagta tcgaaaagct acggaatttc 1094101 tgaaaaagaa gcggaagcga ttcgttataa aacaattcaa agctacccga gcggcgtacc 1094161 ggttcatata tggcagcgta tgaccggagc tccatatccc tacagcgtac atgcggaagt 1094221 tttcaaggaa aaacagcaaa agcaaggctc accggtcgac atgacatttc atttatttga 1094281 gcatccaagc agaatttatg catcaatttg caaattcttt catagtcatg aaaaagaatt 1094341 atagagaata taatgacaac agccttctct tttgcggagg ctgttttgtt ttgggaaatg 1094401 aaaaaccgga agggcggcag atgcaatgga atcaacgctg attgtaggtg cggacgaatt 1094461 tttcggcctt tcattatgtg agcgaatgat ggatgaaggc atacatgttg acgttgttct 1094521 ggcggaaaca gaagataaaa tgagacaaat gtacttagaa gaaagactca tgtggcttgg 1094581 gagaaatgaa ctctttcgcc agcttgaaca cattggagac caaaattatg atacaatttg 1094641 tatccagttc ggaagttttt tgcctttaga ccaatatgat tctccttata ttttagtata 1094701 tgaagaagac cgaaaagaat gggataaacg tgaaaaaaca ggctcggaaa aaaccgtgat 1094761 cctgccgaaa atgtacgggc catggaaaga agaaacagag gaagacggct attacacaaa 1094821 cgacgtggct gacgagttgc tgagattcct gttagaacca agccgtcata gcaaagatca 1094881 gctttttgaa ttgcaagtca cagagaaaac ctcaaaagaa gaagcaaaaa caaaaattat 1094941 cgagtggaaa agacaatttt catcaatttt cgacaaatat taagaaaaac cttccatgtt 1095001 tcgagttttc tagatacaat aaacgtataa aaataataca tgttatagct tgtcaaaagg 1095061 agttgaacat gacttgatca caaggcttgt catgatcttt tctgtcctcc ttttattgag 1095121 tggatgtgga caaactccgt tcaaaggaaa aattgagaag gtcggcatgc tctttcctga 1095181 tacgattaat gacctcgtat ggggcacaaa agggtataaa ggattactga atatacaatc 1095241 caaatacaat gtggacgtct attataaaga aggcgttaaa acagaagaag atatcataaa 1095301 tgcgattgag gattttcata agaggggcgt caatctgctc tacggccatg ggagtgaata 1095361 tgctgaggtg tttaacttgg tcggcgaaga ttatccagat atggaattcg tcatttccaa 1095421 tgcgaaagcg aaagctgata atgtaacaag tgtccatttt agcggggaag caatgggctt 1095481 ttttggagga atgactgctg cccatatgtc gaaaacgaat caggtcggtg taattgcttc 1095541 ctttacgtgg cagcctgagg ttgacggttt tatcaaaggg gccaagtatg aaaatccgga 1095601 tatagaggta aatacgaaat atacggatca ttgggatgat gatacaacag cagtaaagct 1095661 ttatcagaaa atgaagaacg aaggcgcgga tgttgtgtat cccgccggag acgggtataa 1095721 tgttcctgtt attcagcaaa tcaaaaaaga cggtctttat gccataggct acgtcacaga 1095781 tcaatcggat ctgggcgaga ataccgtatt aaccagcacg gtgcaaaatg tggacaaggc 1095841 ctatgaaatc attgctgaac aatttaataa aggcaccctt gagggcggcg atcattacta 1095901 cgacctgaac acgggagtcg ttgagatggg aacattcagc ccgctcgtcg atcaagactt 1095961 tcagcaaaga atcgccaagc tgatcaaaac atacaacaaa acaggcgagc tgccaaaaaa 1096021 cgagtaatgg agtgacgtca catgcagcac gaaaaatcac ttgaattctt gcaaattgcc 1096081 atgaaatatc tccctgaagc gaaagaacag cttgagaaat caggcattga gctctcaatg 1096141 gaggccatcc agccgtttat gaatctattt acaacggtaa tggcggaagc ttatgagctt 1096201 ggcaagtctg acgctaaatc tgaaacagaa taagaagaag ccactttttt gaaagtggct 1096261 tttcacatga ttttcttttt aatagcggag agcatgggcg caagctcctt taaagcgggc 1096321 ttgatttgat caagagagtt cataattgaa ccgatttggt ccataatatg catgtaatta 1096381 atcgtctctt cgtcgtttgt ctgagaaacc tgagaaactt cctcttgctg ttcctcctcc 1096441 ttctcttctg ttggttttgc tgcatcgccg aacatcattc ttgaaaacac atccaactgc 1096501 atacgcctcc tttccatata ccatactcta tgagtaagat gaactgatag tttagacgaa 1096561 tatattgcca tgtgaaaaaa aataggatag aattagtacc tgatactaat aattgatcac 1096621 aacctgattg atcttctaaa tttaagatat aaaggagtct tccctaatga aagctggaat 1096681 acttggtgtt ggacgttaca ttcctgagaa ggttttaaca aatcatgatc ttgaaaaaat 1096741 ggttgaaact tctgacgagt ggattcgtac aagaacagga atagaagaaa gaagaatcgc 1096801 agcagatgat gtgttttcat cacatatggc tgttgcagca gcgaaaaatg cgctggaaca 1096861 agctgaagtg gctgctgagg atctggatat gatcttggtt gcaactgtta cacctgatca 1096921 gtcattccct acggtctctt gtatgattca agaacaactc ggcgcgaaga aagcgtgtgc 1096981 tatggatatc agcgcggctt gtgcgggctt catgtacggg gttgtaaccg gtaaacaatt 1097041 tattgaatcc ggaacctaca agcatgttct agttgttggt gtagagaagc tctcaagcat 1097101 taccgactgg gaagaccgca atacagccgt tctgtttgga gacggagcag gcgctgcggt 1097161 agtcgggcca gtcagtgatg acagaggaat cctttcattt gaactaggag ccgacggcac 1097221 aggcggtcag cacttgtatc tgaatgaaaa acgacataca atcatgaatg gacgagaagt 1097281 tttcaaattt gcagtccgcc aaatgggaga atcatgcgta aatgtcattg aaaaagccgg 1097341 actttcaaaa gaggatgtcg actttttgat tccgcatcag gcgaacatcc gtatcatgga 1097401 agctgctcgc gagcgtttag agcttcctgt cgaaaagatg tctaaaactg ttcataaata 1097461 tggaaatact tctgccgcat ccattccgat ctctcttgta gaagaattgg aagccggtaa 1097521 aatcaaagac ggcgatgtgg tcgttatggt agggttcggc ggaggactaa catggggcgc 1097581 cattgcaatc cgctggggcc gataaaaaaa ggtgaggtgc acacaagatg actaaaaaaa 1097641 gagtagttgt tacaggactt ggagcattat ctccacttgg caacgacgtc gatacaagtt 1097701 ggaataacgc aatcaacggt gtgtccggaa tcggtccgat cactcgtgtt gacgctgaag 1097761 aatatccggc aaaagttgcc gctgaattaa aagattttaa tgttgaagat tatatggata 1097821 aaaaagaagc cagaaaaatg gaccgcttta cacaatatgc ggttgtggct gcgaaaatgg 1097881 cggttgaaga tgcagatctt aacattaccg atgagatcgc gccgagagtc ggtgtttggg 1097941 taggctccgg tatcggagga cttgaaacac tagagtctca atttgaaatc ttcttaacaa 1098001 aaggcccaag acgggtaagc ccgtttttcg tgccaatgat gattcctgac atggcgacag 1098061 gccagatttc tattgcatta ggagcaaaag gggtgaactc ttgtacggtt acagcatgtg 1098121 ctacaggaac gaactccatc ggtgacgcgt ttaaggttat tcagcgcggt gatgcagacg 1098181 tgatggtcac aggcggaaca gaagcgccgc tgacaagaat gtcattcgcc ggctttagtg 1098241 ccaacaaagc gctgtctact aatccagatc cgaaaacagc gagccgcccg tttgataaaa 1098301 accgtgatgg ctttgtcatg ggggaaggtg cagggattat cgttcttgaa gaacttgagc 1098361 atgccctggc ccgcggcgct aaaatttacg gagaaattgt cggctacggc tcaaccggag 1098421 acgcttatca tatcacagcg ccggcccaag acggtgaagg cggagcgaga gcgatgcaag 1098481 aagccattaa agatgcaggc attgcacctg aagaaattga ttacatcaat gctcacggga 1098541 caagcacgta ttacaacgac aaatacgaaa caatggcgat taagaccgtt tttggcgagc 1098601 atgcgcataa acttgcggta agctctacaa aatcgatgac aggccacctc ttaggagcag 1098661 ccggcggtat tgaagccatt ttctctatcc tggccattaa agaaggcgtg attccgccga 1098721 caatcaatat tcaaacacct gacgaagaat gtgatttgga ttatgtgcct gatgaagccc 1098781 gcagacagga acttaattat gttctcagca actcattagg attcggcgga cacaacgcaa 1098841 cattaatctt taaaaaatat caatcataat caagccaaac cggctgccct taaagggtag 1098901 ccggtttttt ttgtgtgcat aggattaaaa gaggaggcga tcacatgagt gtagaacaaa 1098961 catatagctg gctcaggaag gccggttcaa tagatgattt ggcgcattac attatcccgc 1099021 ttttttcagg tgcggagaaa aagaactgga agggcattct ggggcatctt cagcatcatg 1099081 ggatgtttaa aaacataaaa gagggtattc agacggtttc caagctgaag gaaaaaggtt 1099141 tttacggaca tatccaaaag gaagaacagt acctcaaaaa caaatggcaa ggtcctgatg 1099201 taccaattgt tacgctgccg gttgatgaac gaaacaggag aatccgttta gaattcggat 1099261 caaaatcagg actcgccttt caagacaaaa tgttcctttt tctttcgtca gatttagatt 1099321 ttgggtcggt atctgccctt atgacgcatg agtatcatca cgtttgccgg ttaggtcatc 1099381 tgacaaaaga ggaaaaggat gtcacattac ttgatacaat catcatggaa gggctggcgg 1099441 aatatgctgt ttatgagagg ttcggccgaa gtcaaacggc tgaatggacg acttggtata 1099501 caccggaaca gcttcaggct ttatatgaaa aaaagattgc gccccatcgg gatatcaaac 1099561 gggataatcg attatttccc cagctgttat tcggcaaagg atatcagcca aaaatgcttg 1099621 gatacgcagt tggattcaat attgtaaaaa aatatttaac cgccagcaag gcaagcaccg 1099681 cagacgggct gtccattcct gctgagacct ttttggatgc aatgctttaa aaggataaaa 1099741 taatggaatt tcattaataa tattacattt atcctaaaaa attcttgatt ttgcaaaatg 1099801 attgtaataa tatacaacta taaaattttt cgataattca atattattta ttatttctga 1099861 ataaagggat tgctttctct tgaaaacgtt tgacaacaag aggggggaaa ggggagctag 1099921 catgagcaca cttttagaag tgaataattt aaagacttat tttttcagga aaaaggagcc 1099981 gatccctgcg gttgacggag tcgattttca catcagcaaa ggcgaaaccg tcgcgcttgt 1100041 aggtgaatcg ggctccggaa aaagcattac ttctttatca attatgggcc tcgtccaaag 1100101 ctcaggcgga aaaatcatgg acggctctat taaactcgaa gacaaagacc tcacctcatt 1100161 cactgaaaac gattattgca aaatccgcgg taacgaagta tccatgatct ttcaggaacc 1100221 aatgacctcc cttaatccgg tgttaacaat cggagaacaa attaccgaag tgctgattta 1100281 ccataaaaac atgaagaaaa aagaagcccg tcaacgagct gttgaactct tgcagatggt 1100341 cggtttctcc cgggcggagc aaattatgaa ggagtacccg catcggctgt ccggcggtat 1100401 gagacagagg gtgatgattg ccatcgcact gagctgtaat cctaaactgc tcattgctga 1100461 tgaaccaacg acagcgctgg acgtgacaat acaagcccag gtgctggagc tcatgaaaga 1100521 tctctgtcag aagttcaata catcgattct tctcatcaca cacgacttag gtgtcgtgtc 1100581 tgaagctgcc gatagagtga ttgtcatgta ctgcggacaa gtcgtagaaa acgccactgt 1100641 tgatgactta tttttagaac cgcttcatcc gtatacagaa ggcctgctta cgtcaattcc 1100701 tgttatagat ggagagattg ataaattaaa tgcgattaaa ggcagtgtgc ctacaccgga 1100761 taatctgccg ccggggtgcc gttttgcccc aaggtgcccg aaagctatgg ataagtgctg 1100821 gacaaatcag ccttcgcttt tgacacacaa aagcggaaga acggtgagat gctttttata 1100881 tgaggaagag ggtgccgaac aatcatgaca gcagctaatc aagaaacaat cttagagctt 1100941 cgtgacgtaa aaaaatactt tccgatccgg tcaggccttt ttcaaagaaa agtcggtgat 1101001 gtaaaagcgg tggatggtgt ttcattttcg ttaaaaaaag gagaaacact cggaatcgtt 1101061 ggagagtcgg gctgcggaaa atcgactgcc ggcagaacga tgatcagact gtacaaaccg 1101121 acagagggcc aaattctttt taaagggcag gatatttcca atctgtcaga ggagaagctg 1101181 cggaagagtg tccgcaaaaa tattcaaatg gttttccaag atccatttgc ttcgttaaac 1101241 ccgagaaaga ccctgcgttc catcataaag gagccgttta atacgcacaa catgtatacc 1101301 atgcgtgaac gaaacgaaaa agttgaagag ctgcttgcaa gagtagggct tcacccgtcg 1101361 tttgccggcc gttatcccca tgagttttca ggcggccagc gtcagcggat cggcattgcc 1101421 agagcactca ctttgaatcc agagctgatc attgcagatg agccggtttc cgcacttgat 1101481 gtatccattc aggcccaagt gattaacttg atggaggaat tacaggaaga atttaatctt 1101541 acgtatctat ttatctctca tgatctgagt gtcgtccgcc atatcagcga cagagtcgga 1101601 gtaatgtatc ttggcaaaat gatggaactg accggcaagc atgagcttta tgacaacccg 1101661 cttcacccat atacccaagc gcttttatcc tccgttccgg ttacaagaaa aagaggttct 1101721 gtcaaacgtg aacgcattgt cctgaaggga gaactgccta gtccggccaa cccgccaaaa 1101781 ggctgcgtat tccacacaag atgtcctgtt gcaaaaccga tatgcaagga acaaatacca 1101841 gaatttaaag aagctgctcc cagccacttt gtggcttgtc acctttatag ctaatgttgc 1101901 ccgcacagct ttgagagggg gtatgcacac tacataaaca acagcctaga agaacgaaca 1101961 tttcaagagg gggaatatct aatgaaaaga cggaaaaccg cactgatgat gctaagtgta 1102021 ttgatggttc tggccatctt tttatcagcc tgctcgggat caaaatcaag caacagcagc 1102081 gcgaaaaaat cagcaggcaa accgcagcaa ggcggggatt tggttgttgg ttcaatcgga 1102141 gaacccacac tttttaactc tctgtattct accgatgacg caagtacgga tattgaaaat 1102201 atgctgtaca gctttttaac gaaaacggat gaaaaactaa atgtgaaatt gtcactcgct 1102261 gaaagcatta aagaattaga cggcggcctt gcatatgatg tgaaaattaa aaaaggcgtt 1102321 aagtttcatg acggaaaaga actgactgca gacgacgtcg tatttacgta cagtgtccct 1102381 ttaagcaaag attacaaggg agaacgcggt tcaacatatg aaatgctgaa atccgtagaa 1102441 aaaaaggcga ttacgaagtc ttgtttaagc tgaaatataa agacggtaat ttctacaaca 1102501 atgcgttaga cagcacagct attctgccga aacatattct cggtaatgtt ccgattgctg 1102561 atttagaaga aaatgagttt aacagaaaga aaccaatcgg ttcaggacca tttaagttta 1102621 aggaatggaa gcagggccaa tatattaagc tcgaagcgaa tgatgattac tttgaaggaa 1102681 gaccgtattt agatactgtg acgtataaag tcattcctga cgcaaatgct gccgttgctc 1102741 agctgcaggc aggcgatatt aatttcttta atgtgcccgc cactgactac aaaacggctg 1102801 aaaaattcaa caacctaaaa atcgttactg atttggcatt aagttatgtg tacatcgggt 1102861 ggaatgaaaa aaatgaatta ttcaaggata aaaaggttcg tcaagcgcta acaaccgctc 1102921 ttgaccgcga gtcaatcgtc agccaagtat tagatggaga cggcgaggta gcttacattc 1102981 cggaaagccc tttatcttgg aactatccta aagatataga tgttccgaaa tttgagtaca 1103041 acgagaaaaa agcgaaacag atgcttgcag aagccggctg gaaagatacg aacggtgacg 1103101 gcattctgga taaagacgga aagaaattct cgtttaccct taaaacgaac caaggaaaca 1103161 aagtccgtga agacatcgct gtcgtcgttc aggaacagct gaaaaaaatc ggcattgaag 1103221 tgaaaaccca gatcgttgaa tggagcgctc tcgttgaaca aatgaatcct ccgaattggg 1103281 attttgatgc aatggtcatg ggatggagtt tatccacatt cccggatcaa tatgatattt 1103341 tccattcaag ccagattaaa aagggtttga actacgtttg gtataaaaat gccgaagcgg 1103401 ataaactcat gaaagatgca aaatcaatca gtgacagaaa gcagtattca aaagaatatg 1103461 agcaaatcta tcaaaaaatt gcggaagatc agccgtatac gttcttgtat tatcctaaca 1103521 accatatggc aatgccggaa aatcttgaag gatacaaata tcatccgaaa cgtgatttgt 1103581 ataatattga aaaatggtgg cttgcaaaat aaatttccct taaaggggag ggagagcgtt 1103641 ttctccctct tctgttttta ataaggaaag taaaggggga caagtatatg gctgcatata 1103701 ttatcagaag aaccttaatg tctatcccga ttttattggg aattacgatt ttatcatttg 1103761 ttatcatgaa agccgcgccc ggagatccga tgacattaat gatggacccg aaaatcagcc 1103821 aggctgacag agagcagttt attgaaaaat acggtctgaa tgatcctcag tacgttcaat 1103881 atttaaagtg gctaggcaac atggtgcagg gtgatttcgg aacgtctatt gtcagaaaag 1103941 gaacgcctgt ttcagaattg attatggcaa gactacccaa tacgctcctg ctgatgctgg 1104001 tttcaacgat tttggctctt atgatttcta ttccgttcgg tgtcctgtcg gcaaagcggc 1104061 cgtattcaaa aatcgactat ggcattacat ttacctcgtt tataggcctg gctattccaa 1104121 acttttggtt tggattaatt ttgattatgg tgttatcggt aaatctcggc tggtttccaa 1104181 ctgggggtgt cgagacactg aataccgaat tcaatatatt tgaccggatt catcatttaa 1104241 ttctgcctgc attcgttcta gctacagctg acatggccgg actgacgaga tacacgagat 1104301 ccaatatgct tgatgtatta aatcaagatt atattcgcac agcgagagca aaaggattta 1104361 aagagaacag agtgctattt aaacatggat tgaggaatgc attattaccc gtcattacaa 1104421 ttttcggttt gatgattcct tcatttatcg gcggatctgt cgttgtcgaa caaattttca 1104481 cttggccggg attaggaaag ctgtttgtcg attcagcatt ccagcgcgat tatccggtta 1104541 tcatggcaat gactgtgatc tcggcggttc ttgtcgttgt cggaaacctc attgcagaca 1104601 tcctttacgc gattgttgat ccgcggatcg aatattaaaa ggagggaaac agagatgtca 1104661 gagctgcaaa caactccctc gccggagatc aggctgaaag aaaatatttc gaaaaagcca 1104721 gaaacaatga caaagatttt ctgggaaaaa ttctcgaaaa acaaactggc cattttaggt 1104781 gccgttattc tttttatcat tattatgtct gctgttttcg cccctttaat tgcaccttat 1104841 ccccaagagc agcaaagcct gcttgataaa tataaggcgc cgggccttga acatctgatg 1104901 ggaacggata aatttggacg tgatattttc agccggatcc tatatggagc gcgtgtctct 1104961 ttattggttg gatttgcgtc cgtagtcggt tcgattttga tcggaacggt tttaggagca 1105021 ttagccggat atttcagagg aatagtggat gctgtcatta tgcgtgtagt tgacattgtg 1105081 ttatccattc ctgatatttt cttgttgatc acgctggtca ccatcttcaa gccgggtgtg 1105141 gacaaattga ttttaatttt ctgtctcaca ggatggacca caacagcacg attagtaagg 1105201 ggagaattct tgtcgctccg ttcaagggaa tatgttcttg ctgctaaaac aattggaaca 1105261 aaaacgcaca aaattatttt ttctcatatc ctgcccaatg cgttagggcc gattatcgtg 1105321 tcagctacgc tgaaagttgg gtctgttatt ctagctgaat cggcgctaag ctacttgggc 1105381 tttggaatcc agccgccaat cgctagctgg gggaacatgc ttcaagacgc acagaatttc 1105441 acagtaatga ttcaagcatg gtggtacccg ttatttcccg ggctatttat tttaatgacc 1105501 gttttatgct tcaactttgt cggtgatggc ctgcgggatg cgcttgaccc gaaaaatatt 1105561 aaataaaaat gaatatcata tctgttataa aatatcacca aatcagaaaa aagcaggtct 1105621 cctttagtca gaaaatatac aaagagatct gctttttatg attcttacat aaacccagtg 1105681 attccagatt tcctcaatct ctttggaata atttctctat cccttgccta tactgtggac 1105741 aacagttttt ataaaagtga ggggttagag atgttatttc ttcatgatgt gtgggtcaat 1105801 tggtttgaag gggaagaaaa tggctacaat gtatgccact ttcacgaatg gcgcaaggaa 1105861 gatacggttg agcttttgga tcaggtgccg ctgttaaggg tgccgtcagt actgtttcat 1105921 tacatagaaa acgatttgtc agagcttccg aaaggtttgc ttgaagacgt acatcagaaa 1105981 tcgtacattc gaaaaaatca tgagcggaca aagcttgagt attgttttgt cgtaacagac 1106041 ggaatcggca ttttagctgt tgacacgatc ggctacacga tccctgtcag aaaaagccgt 1106101 ctaatcccaa gacaggagca gctcgtttat gaaatggtaa aagatgtaga gcctgaaaca 1106161 tatgaatttg agccaaagaa gctggaatcc tccaaggaat atcacatctt atcattagca 1106221 ccagaacatg tcagaggact gacaagaaaa gaacggcaaa ttaagcagct gatgtttatg 1106281 gcgcttgacc aattaaaagg gctgaaaaac cgagcggaaa ttggctactg gtacacagag 1106341 tggaatccgc atatgtatga acaaatcaaa aggatgagct ttgaagagat ttgggacatg 1106401 ctgtataacg aaacaattga aggctggtcg gacaaacacc tagctttttg cgaaaaccta 1106461 ataaaaggac agcctttttt cgaaaagctt tgggaaatgg aaaacgaatc aaaggtcaac 1106521 tgaaaaaaac cgctctttgc aaagagcggt tttttgatta gcgtcttttt cttccaagac 1106581 ccatggcatt ctccattttt ttcagcattt tgtttgctgt ccgattcgct cgttccgcgc 1106641 cttcatcaag aatccggtct aattcttcag attctatcag ctcgtaatag cggtcctgga 1106701 tcggttttaa tgcgttcact acgacttctg ccaaatcacc tttaaactcg ccgtagcctt 1106761 ttccttcgta ctttgcttca agctcttcaa ttgtcgtatt gccgaggatt gaataaattg 1106821 taagaaggtt ggaaacgccc ggtttgtttt ccttatcaaa tttgacaatg ccttcagaat 1106881 ccgttactgc gcttttgatt ttcttttcaa gctgcttcgg ctcatccagc aatgtaatat 1106941 aagctttctg attcggatca gatttgctca ttttcttcag cggatcattc agagacatga 1107001 tacgtgcacc gacttttgga attttcactt ccggaatcgt aaagatgtcg ttgtattttt 1107061 tgttgaagcg ttctgcaaga ttccgcgtca gctcaaggtg ctgcttttga tcctcgccga 1107121 caggtacaag atccgttccg tacagcagaa tatcagcggc catcagcggc ggatatgtta 1107181 acaggccgga gacgacagct tcattgcctt tggatttgtc cttaaattga gtcatccgct 1107241 caagctcgcc gatataggcg acacactgca tcatccatcc ggcctgcgca tgtgcgggga 1107301 cctctgactg aataaacaat gttgcttttt ctggatcaag tccgacagct aagtaaagcg 1107361 ccgcgagatt gcggatattc tttctaagct caagccggtc ttgaggaaca gttatcgcat 1107421 gctgatcgac gatgcaaaaa tagctgttat aatcatgctg cagttcgaca aactgcttca 1107481 ttgcaccgat atagttgccg agcgtcactg agccgcttgg ctgaatgcct gaaaaaatcg 1107541 tttgtttcat gaaaacatca acctcatttc ttaaaacata ataaaaaagg ctcattcttc 1107601 ccctgtaaaa aagggacgaa tgaaccgtgg taccaccctg attattccat taaaatggaa 1107661 tcactctgac gtttgtaacg gagactgctc cggctgagcc tacttttttc cagttcggtc 1107721 agctgctcca aagtccattc cacattgccc gttatctgct cccagcaccg cagactctct 1107781 tcaaacaggt gaaacgtgta ctactctttt tcatagcaag cttttctttt gattgcttca 1107841 ttataaatca attataacca attgtcatca tgaaaaaaca ttcttttttc cagtaaaatt 1107901 gtaataatat aaataacacg agtgctgtaa aatccttaaa tgataactgc tatcagcgta 1107961 aaaacaggca gatattatat gtaaaaagca atatgggcag aaaacacatg aaaaagtttt 1108021 taatcaattt atgctttaaa tggtagaagg atattatgtt catggaagaa aaactaacga 1108081 agtttaaata ttttaaattg ataaaataat attgcaataa attatttgtt tcattataat 1108141 gaacttgttc actctattgt tacagctttt ttacaaaaat aatcagaaaa gacggaacag 1108201 aataaaagtt gtggaaactc aggttcattt gtctgatatt tctgaggatt tagccgtaag 1108261 gagctgaaaa ttattattag ggggtttgcg aatatgaaaa aacgttggtc gattgtcacg 1108321 ttgatgctca ttttcactct cgtgctgagc gcgtgcggct ttggcggcag cggatcaaac 1108381 ggtgaaggga aaaaggacag taaaggaaag acgacactta acattaatat taaaactgag 1108441 ccgttctcct tacatccggg attggcaaat gattcagtat caggcggtgt tatccgtcag 1108501 acttttgaag gattgacacg tatcaatgca gatggtgagc ctgaagaagg catggcttct 1108561 aaaattgaaa cgagcaagga cggaaagaca tatacattta ccattcgtga tggtgtgaaa 1108621 tggtctaatg gagaccctgt aactgcacaa gattttgaat atgcttggaa atgggcgctt 1108681 gaccctaata atgaatcaca atacgcttac cagctctact acataaaagg tgctgaagcg 1108741 gcgaataccg gaaaaggcag cctagacgat gtggcagtaa aagctgtgaa tgacaaaacg 1108801 ctgaaggttg aattaaataa cccgactcca tatttcactg aattaactgc gttctatacg 1108861 tatatgccga tcaataagaa aattgcagag aaaaataaaa agtggaatac aaatgccgga 1108921 gatgattatg tatcaaacgg gccgttcaaa atgacggcat ggaaacacag cggctctatt 1108981 actctcgaaa aaaatgacca gtattgggat aaagacaaag tcaaactgaa gaaaatcgat 1109041 atggttatga tcaacaataa caatacggaa ctaaaaaaat tccaagctgg cgaacttgat 1109101 tgggccggta tgccgctcgg acagcttccg acagaatccc tgccgaccct gaaaaaagac 1109161 ggttctttac atgttgagcc gattgcagga gtgtattggt acaaattcaa cactgaagct 1109221 aagccattag acaacgtcaa tatccgtaaa gctttaacat attcgcttga ccgtcagtcg 1109281 attgttaaaa acgttacgca aggagagcaa atcccggcaa tggctgcagt gccgcctaca 1109341 atgaagggat ttgaggataa caaagaagga tacttcaaag acaatgatgt caaaacagca 1109401 aaagaatacc ttgaaaaagg cctaaaagaa atgggcttaa gcaaggcatc tgatttgcca 1109461 aaaatcaaat tgtcttacaa cactgatgac gcacacgcga aaatcgctca agcagtacaa 1109521 gaaatgtgga agaaaaattt aggcgttgat gttgagcttg ataactcaga gtggaatgtc 1109581 tatattgata agctccacag ccaagattat caaatcggcc gtatgggctg gctcggcgac 1109641 ttcaatgatc ctatcaactt ccttgaattg ttccgcgaca aaaacggagg aaataacgat 1109701 acaggctggg aaaatccaga attcaaaaag cttctgaatc agtcacaaac tgaaacagat 1109761 aaaacaaaac gtgcagagct gctgaaaaaa gcagaaggta ttttcattga tgaaatgccg 1109821 gttgccccaa tctatttcta tactgatact tgggtacagg atgaaaacct aaaaggtgtt 1109881 atcatgccag gtactggtga ggtttatttc agaaacgcat attttaaata aggctacgtc 1109941 tgaaaataaa agacctcaag gtatatgggg agaaaagccc catatacctt tcttactgat 1110001 ggagtataaa aatgtaaaaa ccatggaggt gttccccctt gctaaaatat atcggaagac 1110061 gcttagtcta tatgattatc acactatttg tgattgtaac tgtgacattc ttcttaatgc 1110121 aagcagcacc gggcgggcca ttttcaggtg agaaaaagct tccgcctgaa attgaagcaa 1110181 atttaaatgc gcattatggc ttggacaagc cgctgtttgt acaatatgtc agttatttga 1110241 aatcagttgc aatgtgggat ttcggaccgt catttaaata taaaggtcag agtgttaacg 1110301 acctgatcag ttcaggtttc cccgtttcat ttactcttgg agcagaagct attctcctcg 1110361 ctttagcgtt aggtgtattg tttggggtca ttgcagccct ttaccataat aagtggcagg 1110421 attataccgt cgcgatttta acgatatttg gtatttcggt tccgagcttt atcatggcgg 1110481 ctgttctgca atatgtgttc tccatgaagc ttgggctgtt tccggtcgcg gggtgggatt 1110541 cctgggcata cacctttttg ccttccatcg cacttgcttc catgccgatg gcgtttattg 1110601 ccagactttc ccgttcaagc atgatcgaag tgttaaacag tgattatatc cgcacagcga 1110661 aagcgaaagg gctttcccgc ccagcggtta cagtgcggca cgccattcga aacgcacttt 1110721 tgccggttgt tacatatatg ggcccgatgg ccgcacaggt cttaacgggg agcttcatta 1110781 ttgaaaccat ttttgggatt ccggggcttg gtgcacactt cgtcaacagt attacaaacc 1110841 gtgattatac ggtcattatg ggtgtaacgg tgttcttcag tgtcatcttg ctattgtgtg 1110901 tattaatcgt agatgtgtta tacggcatta ttgatccaag aatcaagctt tccaaagcaa 1110961 agaaaggagc ctaggccatg cagaacattc caaaaaacat gtttgaacca gccgcagcga 1111021 atgccggcga tgcagaaaaa ataagtaaaa agagcctttc cctctggaaa gatgcgatgc 1111081 ttcgcttccg cagcaataag cttgcaatgg tcgggcttat cattatcgta cttattatcc 1111141 ttatggcaat ttttgcgccg atgttctcaa ggtatgatta ttcaactact aatctcttaa 1111201 atgcggataa gccgccttca aaagatcact ggttcggaac agatgatctt ggacgggaca 1111261 ttttcgtccg tacatgggta ggggcgcgaa tctcaatctt tatcggtgtt gcagctgctg 1111321 ttctcgattt gctgatcggc gtcatttggg ggagcatttc aggcttccgc ggaggaagaa 1111381 cagatgaaat catgatgcgt atcgctgata tcctttgggc agttccttca ttattaatgg 1111441 ttatcttact gatggttgtt cttccgaaag gtctatttac gattattatt gccatgacga 1111501 ttacaggctg gattaatatg gccagaatcg tgcgcggaca agtgctgcag ctgaagaatc 1111561 aggagtatgt gcttgcttca cagacactgg gtgcaaaaac atcccgtctt ctatttaaac 1111621 atatcgtgcc aaacgcaatg ggttctattt tggtcacgat gacactgaca gttcctactg 1111681 cgatttttac agaagccttt ttaagctatt tgggacttgg tgttccggct ccgctggcaa 1111741 gctggggaac gatggcttct gacggattgc ctgcattgac ctattatccg tggcgtttat 1111801 tcttccctgc cggatttatc tgcattacaa tgtttggttt taacgttgtc ggcgacggat 1111861 taagagacgc attggatcct aagttacgta aataagggag tgatacgggt gacacgccta 1111921 ttagaagtaa aagatttagc aatttcattt aaaacatatg gcggagaggt ccaggcgatc 1111981 cgcggagtga atttccatct ggataaaggg gagacgctgg ccattgttgg agaatcaggt 1112041 tccggaaaaa gtgtaacctc tcaagcgatt atgaagctga ttccaatgcc tccgggttat 1112101 ttcaaacgcg gtgagatcct gtttgaagga aaggatctgg tgccgctgtc cgaaaaagaa 1112161 atgcaaaatg tccggggaaa agagatcggc atgatattcc aagatccgat gacctcttta 1112221 aatccaacga tgaaggtcgg taaacaaatt acggaagtgc tttttaaaca cgaaaagatc 1112281 tcgaaggaag cggctaaaaa acgcgcggtt gaactgctgg aattagtcgg tatcccaatg 1112341 ccggaaaagc gggtgaacca atttccgcat gaattttcag gcgggatgag acagagggtt 1112401 gtcattgcca tggcgcttgc agcgaatccg aaacttctga tcgccgatga gccgacaact 1112461 gctcttgatg taacgattca agcgcaaatt ttggaattaa tgaaggattt gcaaaagaaa 1112521 attgacacgt ccatcatctt tatcacacac gatcttggtg ttgtggctaa cgttgctgac 1112581 cgggtcgctg tcatgtacgc gggacagatt gtagaaactg gtacggtaga cgaaatcttc 1112641 tacgacccga gacatccgta cacttggggg cttcttgcat ccatgccgac actggaaagt 1112701 tcaggagagg aagagctgac tgcaattccg ggcacgccgc ctgatttgac aaacccgcca 1112761 aaaggagatg cttttgccct gcggagctct tacgcgatga aaatcgattt tgaacaggag 1112821 ccgccaatgt ttaaggtatc cgatactcat tatgtaaaat cgtggctgct tcatcctgac 1112881 gcgccaaagg tagagccgcc tgaagcggta aaagcgaaaa tgcgtaaact ggcaaacacg 1112941 tttgaaaaac ctgtcttagt gagagaagtt gaatgaattg actgaaaaac tattagaaat 1113001 caaacattta aaacagcact ttgtcacgcc gaggggaacg gttaaggctg tagatgattt 1113061 atcatttgat atctataaag gtgaaacatt agggctggtt ggtgaatctg gctgcggtaa 1113121 atcgacaaca ggccgaagca ttatcaggct gtacgaagca accgatggtg aggtgctgtt 1113181 caacggcgaa aatgtgcacg ggagaaaatc gcggaaaaag ctgctggaat tcaaccgcaa 1113241 aatgcagatg attttccaag acccctatgc atccctgaat ccgagaatga cagttgctga 1113301 tattattgct gaaggccttg atattcataa gctggcaaaa acgaaaaaag agcggatgca 1113361 gcgagttcat gaactattgg aaacagtggg attgaacaag gaacacgcga accgctatcc 1113421 tcatgaattt tccggcggcc agcgccaaag aatcgggatt gccagagcgc ttgctgttga 1113481 tccggaattc attatcgcgg atgagccgat ttccgctttg gatgtatcca ttcaagcgca 1113541 ggtcgtgaat ttaatgaaag aactgcaaaa agaaaaaggg ctcacatacc tgtttattgc 1113601 ccacgattta tcgatggtca aatacatcag tgaccgcatt ggcgtcatgt atttcgggaa 1113661 actggttgag cttgcgccgg cagatgagct ttatgaaaat ccgcttcacc catatacaaa 1113721 atcattgctt tctgcgattc cgcttcctga tccggactat gagagaaatc gcgttcgcca 1113781 gaaatatgat ccgtctgtcc atcaattaaa ggatggggaa acgatggaat tccgtgaagt 1113841 caaaccggga cattttgtga tgtgcacgga agccgaattt aaagcttttt catgattcat 1113901 caatccttca agagatttct cttgaaggat ttttttgcgt cttcatagaa agtgagaatg 1113961 ataacattta caattagagg aaaaagcgga ggcgaaatac gattcaattt ctgcataaca 1114021 aaaatgtttt tgcgctattg ctgtctcaat cttttcaatc tttagcagga gtcctcgtca 1114081 caatcgtttt aatggtccgg atctatcaaa tgactgactc cgtttttttg gcgggcctta 1114141 ttttatcgtt catgtcgttt gcgagtatag cagcaagctt ttgcgtctct ccggtgcttc 1114201 gcattctcgg ttttaaaaag gtgcttgcgg gagcgaatct gctgagagcg gtctttatta 1114261 tactgatggc atacagcgtc actcatcacg gacaggcatt cttttggatt acgctgctgt 1114321 ttgtgttttg tttttccttc gcgggcgctt tttttcagcc ggcaagattt gcgctgctgc 1114381 cgattattgt tccaaagaag caatatgtaa aagcgaatgg tgtgatctcc ctctcgaatc 1114441 aattgttctt aacagcaggc tggggccttg gaggccttct gacgtacgcc gtcccttttg 1114501 aactcgttgt cggcgctgcc atttgcctgt ttgttctatc gggagcttcc atcagtgtgc 1114561 tgcatgtaaa tgaagaagag gctgcaggaa ctgctgaaac agcatctgtc agaagtatat 1114621 ggaaggattt aatgatcatc cctattgtaa gagacattac tgtaatggac atgttagaag 1114681 ctttggcggg ttccgtatgg tcatctgcta ttctcctcgc atttactgcg gctgttttgc 1114741 atgaaacaga ggtgtggtgg gggatgttta acgcttccta ttttataggc gcaattgtcg 1114801 gcagtgtgat tgctattcgt ttttcttctt tttttgagcg gaatatgggc tatgccatta 1114861 tgttcagctc gcttgtaatg tcggcgctga cccttttgtt ttcattttct ccagtcccat 1114921 ttttatgcgc tctggcttgt gctgcaatgg ggccttttta tcaggtgcgt gatatttgcc 1114981 aggaaaccat gctgcaggaa gttattcccg agcagaaacg aatcggaatc atggctgcaa 1115041 aaaatgcgat tttgactcct tggtcaggcg tcacctactc cattatgggg ctagtggctg 1115101 atgctgctgg tgcgaaaata gcttttatcg cggctgctgc attatatatc atgacatttc 1115161 tgattgcact ggcgcagccc cgtctggttc attacaggcg agaaaatcga gttcaatgag 1115221 aaacacttca aaatgaacgg agcagctggc tccgttttgc tgaaaaaaaa atgaaaccat 1115281 ggcggaagtt cgcacgtctt tatagatgta aggctgttta aacaagaaga aatggggtat 1115341 atctaaaagt atgaagacaa cgaactcata aggagcaaat caatgaactg gtatgaaaag 1115401 cttagcgagt actttccaat tgaagaaatg aaatcaaaag cgcatatgga agctcttctg 1115461 aaagagcgaa gcgatattta tcataaagat gaaggcaaac atcatatttt aatgtttgcg 1115521 gaattcgatt cttttatctt cgttgattat ctgtatgtgt ctaaggatgc aagagggcag 1115581 gggcttggcg gcaaattgat cgcgaagctg aaaaagaaaa ataagcccat attgctcgag 1115641 gtggaacctg tggatgaaga tgatactgat acagaaaaac gcctgaggtt ttatcaaaga 1115701 gagcatttca agcatgctca gtcaattggg taccggcgcc ggtcattggc tacgaatgaa 1115761 gtaaacaaga tggagattct gtactggtca ccaaaaacag aatcagaaga agaaattctt 1115821 gaagccatga aacagacata tgaaaacatt catacttata aagatgagaa atggtacgga 1115881 gaatcgtacg aaaaaacgga tgaggtcttg gaaatcatcg atgaagaaaa acaaaaaaat 1115941 attttcgatc agttaagcta attgagaata agaacatatc atgaacatta aaaatttgct 1116001 ggattgacac atttttttct taggatactg ttcacactta cttttttata gtataatacc 1116061 tgtaaagatt ccttttttag agtaatttca atttaagaat aaaatagatg ttcatcctac 1116121 taattagagg agtgaagatg aatggttaca ctatacacat caccaagctg tacttcatgc 1116181 agaaaggcga gagcgtggct cgaggagcac gagattccat ttgtagaaag aaacattttc 1116241 tctgaacctt tatcaattga tgaaataaaa caaattcttc gaatgactga ggacggaaca 1116301 gatgaaatca tctcaacccg ttcaaaagta ttccaaaaac tgaatgtgaa cgttgaatct 1116361 atgccgctgc aagatttgta ccgcttgatc aacgagcatc caggtttgct tcgccgtccg 1116421 atcatcattg acgaaaaacg tttgcaggtc ggatataacg aagacgaaat cagacgtttc 1116481 ctgccaagaa aagttcgctc tttccaatta agagaagcac agcgtttggc aaactaatag 1116541 atcgtatcat caaaagaagg ctgagtcatc agccttcttt tatttttcaa cctgctggta 1116601 ataaatgctc gcaaggatga caaacgcaac cgtcaaaatg gggaggagcg tttcgactgt 1116661 gccgtgctgc gccataaaaa gcgacagctt tttgtctctg acaatcattt ctccgccagt 1116721 ataagcaagc agcccgcttc ccgcgtaaat cagaagcggt attttctcta gtgcaatatg 1116781 gatgagtttg ctgccccaaa taataaccgg aaccgataca cacaatccta taacaacgag 1116841 agaaaactca ccgtgtgaag ctcccgcaac tgcgatgacg ttgtccagcg acataaagag 1116901 atctgcaagc acaatcgttc gtatcgctct ccacagggag gtgctgcttt taatgtgttt 1116961 cgtgtctttt ttttcaatca gcagctgata tcctaaatac agcaggaaaa ttccgccggc 1117021 gcactgcaag aacggaatgt tcaaaagata tactgctgca cttgttaatc cgattctcat 1117081 ggcaacggca ataaatgttc cgagaataat ggcttgctgt ctttgcttgt ccggcaaatg 1117141 tctgctggcc atggcaataa caaccgcgtt atctccgccg aggatcaggt caatcccaac 1117201 aatgacgagc agagaaatca gatagtcatg ctccatgaag cggcacctcg ctttcagtcc 1117261 ttcgcttgta ctactactat atgagacagg tcatatttta tgatatcagc cgcctgatct 1117321 gccgtttttt aggcaaaggt gcatttttat ttcttttgtg actgttttat cataaaatag 1117381 aaatacaaag gaattcacac tggccttggt taaggttaag atgtggacgg aatgggtaaa 1117441 gtgtagtaaa gtacaattaa tcgggagctt agatgtccct tcaacatctt atatagaagg 1117501 gaaggttggc aaatggaaat tgaaagaatt aacgagcata cagtaaaatt ttatatgtct 1117561 tacggagata ttgaagatcg cggttttgac agagaagaaa tttggtataa ccgtgagcgc 1117621 agtgaagaac ttttctggga agtcatggat gaagttcatg aagaagagga attcgctgtg 1117681 gaaggcccac tttggattca agttcaggca ctggacaaag gattagaaat catcgtcaca 1117741 aaagcccagc tttccaaaga cggacaaaag ctcgaactgc cgattcctga ggataaaaag 1117801 caagaaccag catctgagga tcttgacgcc ttgctggatg atttccagaa agaagagcaa 1117861 gccgtcaatc aggaagagaa ggagcaaaag cttcaatttg tcttgcgatt tggcgatttt 1117921 gaggatgtta tttctctatc taaattgaac gttaacggaa gcaaaacgac tttatattcg 1117981 tttgagaacc gatattattt atatgtagat ttttgcaata tgactgatga agaggttgaa 1118041 aatcagctaa gcatcctgct ggagtacgca actgaatcct caatcagcat acaccgtctt 1118101 gaagagtacg gcaagctgat tatttcagag catgctctag aaacgataaa aaaacacttt 1118161 gcatcatagc aaaccgattt ccttccggaa atcggttttt tttatgcacg aaaatgccat 1118221 tttagagatg tgaaaaatca aaaacatata gacaagcaga aaatacagcg aacaggagtt 1118281 gatcatcttt tccagaaagt atacttcatc tggaaaggag agatgacaat tgtttagtgc 1118341 tgtgactgaa gacggccaaa tgtttcacct tctaggcgct cagcaaaacc agaaattaaa 1118401 gcggagacgg ttcttctgtc cggtatgcgg gggagagcta gctgtgaagc tcggacttca 1118461 aaaagcgccg cattttgccc ataaacagaa caagtcctgc gccatagaca tcgagccgga 1118521 aagcgcctac cacttagaag gaaaaagaca gctgtatgta tggctgaaaa cgcaacgggc 1118581 ttcaccaata ttggagccgt atataaggac aatcaaccaa agaccggacg tcatggcaag 1118641 aatcaaggag catatgcttg ctgttgaata tcaatgcgcc actatcgctc cagatgtctt 1118701 tcaaaagcgg acagagggct tcaaacaaga aggaatcatc ccgcagtgga ttatgggata 1118761 cagccgctta aaacggactg cttcgtcctt ttatcagctt tcaacttttc attggcagtt 1118821 tatcaatgca agtccataca gagaactgat atgttattgt cctgaaaggc gttcttttct 1118881 ccggctcagc cacatcattc cattctacac aaaccattct tattcctcag tccaaacgat 1118941 ccctatccat cgggcaggtg caggcgatct ttttttcact gaaccgaaac cctcaattca 1119001 atattcaggc tggacgaaag cgattcaccg ttttcgccat aaaccccatc ggtttaactc 1119061 aaaggaaaca aatcgcctta ggctgctgtt ttatgagaaa cgacagacgc ctttttcttt 1119121 tctgccgact gaagtgtttg ttcctgttag aaaaggggca gtttttaaga gtccggtttt 1119181 tgtgtggcag gggtttcttt atttgtttat gacggatctt ggaggtaaac gtgcgccaat 1119241 tcgtttttca gccgttttgc agcagtgcaa actgcacatt cataataaga acattgcact 1119301 caggtccgaa tgcagcgaag agtgtctttc agaagcggtt aaacagtata ttgatttttt 1119361 gtgcaagaag ggatttttaa gggagactca gaaagaagta tatgtgctga atcagcctgc 1119421 aggaggcata cactccatgc aggatctcat agaaagagac cgcagctgtt ttatagaatg 1119481 agtttgtctt atttggctca ccctaagaca aaggtggtgg gcaggctgtg aaaggcacaa 1119541 aaggaaaggt ttttcgtgtt tttactgctt ttttggcatt cgttctcttc attactgcat 1119601 atgatttgac aaaaggcagt gaaaaaccgg aagatattca caacacaagt ttattgagaa 1119661 acagctgttt tttcaattgg cttgaatcaa agaagacgag ggggatcacc atggctgagg 1119721 aaaaaaaagc aaaccaactg cctgacagaa gtgaggtaaa ggcagaagac acatggagac 1119781 ttgaggatat ttttcctagt gatgaggcct ggaataaaga atttcaagct gtaaaagaat 1119841 taattccgaa tttatctaag tataaaggaa agctggcaga ttcagctgat catttatacg 1119901 aggctcttac gtatcaagat aaagtgatgg agcggctagg taggctgtac acatatgcgc 1119961 atatgcgctc tgaccaggat actgggaact ccttttacca ggggctgaat gacaaggcgg 1120021 gaaacctgta tacacaggcc gcaagcgcga cagcttattt ggttccggag attttatcca 1120081 tagaagaaga caaactgcag cagttcattc ttgaaaaaga agaattgaag ctgtactctc 1120141 atgcgattga ggagattaca aaggaacgtc cgcatgtgct gagcgagaag gaagaggcgc 1120201 tgcttgctga agcctccgag gtactggggt catcttcaaa tacattcagc gtgttaaata 1120261 acgcagatat aacgtttcca tccattaaag acgaagatgg gaatgaaaaa cagatcactc 1120321 acggcaactt tattaatttc ttggaaagtg aaaaccgtga agtccgcaaa aatgcgtttg 1120381 acgcagtgta taaaacgtac ggacaatata aaaacacaat ggccacgacg ctaagcggca 1120441 ctgtgaaaaa ggacaacttc tacgcgagag tgaaaaagta caagtccgcg cgtgaggctg 1120501 cgctttctaa caacagtatt cctgaggaag tatacgataa ccttgttaag acgattaata 1120561 agcatttgcc gctcctgcac cgctatattg cgctaagaaa gaaagtgctt gagcttgatg 1120621 aagtgcatat ctatgacctg tatacaccgc ttgtgaaaga tgctgggatg aaggtgacat 1120681 acgaggaagc caaagattac atgctgaaag gcctcgcacc tttaggggaa gaatatgcct 1120741 ctatcctaaa agaaggactg gaaaaccgct gggtggacgt ttacgaaaat aaaggcaaac 1120801 gcaatggggc ttattcatca ggagcttacg gcacgaatcc gtatattttg atgaactggc 1120861 ataataacgt caataatctc tttacgctcg tgcacgagtt tggacattcc gtacacagct 1120921 actatacgag aaagcaccag ccttatccat acggcaatta cagcatcttt gtcgcggaag 1120981 ttgcctctac gacaaatgaa gcgctccttg gcgaatattt gctgaacaat ttagaggatg 1121041 aaaaacagcg cttatatatt ctcaaccata tgcttgaggg cttcagggga acggtcttca 1121101 gacaaacgat gttcgctgaa tttgaacatc tgattcatac aaaggcgcaa gaaggcgagc 1121161 cgcttacacc tgagcttctg acaaatgtct attacgacct gaataaaaag tattttggag 1121221 acggcatggt gattgataag gaaatcggcc ttgaatggtc gcgtattccg cacttctatt 1121281 acaattacta tgtgtatcag tatgcgacag gttacagcgc tgcccaagca ttaagcagcc 1121341 agattttgaa ggaaggaaag ccggcggttg accgttatat tgacttcctg aaagcgggaa 1121401 gctcacaata cccgattgat gtcctgaaaa aagcgggtgt tgatatgacg tctccagagc 1121461 caatcgaagc cgcgtgcaaa atgtttgaag aaaaacttga tgaaatggaa gagctgctga 1121521 tgaaagtcaa gcagtcttaa aaaagtaagc ctgtgcggaa atgacgcaca ggctttttta 1121581 aaacccttta aaggttttcc ggtgattcaa gcggtagagg gtaaacaaaa tagacagaaa 1121641 cagcagagga gaggtaatat aaagcggcag catatgcatc atgcctaaga tattcaagca 1121701 gaaaaaaaca gcaatgcaca caattgagat caaagtagac atcatggcgg tcctcctcgt 1121761 cctttttcct tataaggata tgagtgaatg cacttcgtta tgttttgtga caaaaatatg 1121821 aacattaagc atagaggttg tcaaaagtcg acatcttttg ttatcataag gatgtgaaat 1121881 tgatcacaaa caaacattac ccctttgttt gaccgtgaaa aatttctccc atcccctttg 1121941 ttgtcgttaa gacatatgaa accgcgctta tcccggcgcg gtttctttag tgctaaaaat 1122001 ggaacgtacg tttggttatg gcataaaaaa acagcctcaa gcatatgcac gcctgcggct 1122061 atttttcaca tgattgatat tcatcagaat aagtgctgag agacttccaa aacattccgt 1122121 gtttggcttc cactttggca acctttttag caaacgccag ttttttcatt tctttttcta 1122181 cctcttcaag gctcaggtca tatacaagag caatttcctt cgaggcaacg aagcggaaat 1122241 attcaataaa acattctaaa ggcggtgttt ccgacggctt cggctcgtcg ccaagcatct 1122301 caaataaaat ttcttcatat acatcatatg agtagctgcc aggaacttta agcccttcat 1122361 cctcatgctg cgtattaaaa aacgtcagtg tcggattaac agaaacatcc atctcggcag 1122421 caattttcat gtcacattga agcgccttga ccgcgctttg agaatgcaga tcttttttga 1122481 attcttcaag atcgagactt gtattttcag caatctccaa aagcacgttt tcatccgtaa 1122541 tatttttctt tgaaacaaat aggctctcct gcatatttct gagaaattgc atgccggctt 1122601 ttcgtccttg cagttcggct gctttaaaag cgagagcagc catataaggc gatgaaagcg 1122661 gctgatcctg ttcgaaccag acattgccgt cacatgacat gccagagcgg ctcgcgatct 1122721 tttcccatgc ttctgcgaga agatgctttt ttcgcttttt atttaaagcg gtaaggcttg 1122781 cggaagcgat aatgcgtaag gtgaaaaaac gtccgtatct gattttcagc tttttgatga 1122841 cgggctctaa ggaccagcat tcaggacata aagggtctac aaacatataa atttcaagcg 1122901 gtttttttgg atgaccgtgg caatgggcga agtatagctc atgctgatag tttgtcaaga 1122961 tgatcgatcc tccgcttccg tttgattcac catatgcctt gctgtcaact ccagccggcc 1123021 aaacaaaaac tcacgaattt cgccctccag ccctacatgg tccattgcgt ccttcataca 1123081 gctgagccac gcatcagctc tctcgtttgt aattggaaag ggaagatgcc ttgctctgag 1123141 cataggatgg ccgtgttcct cagtataaag aggaggcccg cctaaatact gagttaagaa 1123201 ttgcttctgt ttcctggcgg tttctgtcaa atcgcttgga aaaatcggct tcagcaaagg 1123261 atgagacgcg acacgctcat aaaaagtatc aacaagttgc gatagaagtt cctctccaat 1123321 cgcttcataa ggtgcgttaa acgattgtcc catgttgact actcctttaa atatggctaa 1123381 taggaatcat aaatcctatt gcaaaaagta attttctgta tttcattgtt tcatctagat 1123441 ttattttagc aacaaggcat catttctaca aacaaactgc cttttatgcg tttgatgact 1123501 catttcggct gacagccggg gtttgtattt catatcatat cacataaaaa tcaggaatgc 1123561 gtaagatttc acttcgcaaa aaaaccagag ggaaagagca cctctggtta cgcgtaataa 1123621 actgaagtta ttttttttac atagttttgc gtttcttgga aaggaggaat gcctccgtat 1123681 cggtcaacat tccccggtcc ggcgttgtaa gccgctaatg ccatagacac attgccgtcg 1123741 tatttatcca gcatttgttt taaatatttc gttccgccct ccacattttg ctgcggatca 1123801 agcggattgg aaacgccaag tgagcttgct gttgacggca tcagctgcat gaggcccatc 1123861 gcacctgctc cgctgaccgc ttttgcatta aagcctgatt cctgtttgat gacggcgcgg 1123921 atcagttttt catcaacgcc atatttatca gcggcttttt taatcgcact gtcaatagag 1123981 aagtctcccg aacggatctg atttgcttca tgtttgtttg aagctgaatc tgcaacagct 1124041 gtttcagtgc tttctgccgc ttttgtgact gaacctgaat tgctgctcgt atatgagtta 1124101 agcccatacg ctgaaagcag tgacggcgct gttgtattcg cgctgttcag catgctgagc 1124161 gggcttggcg atgaagaagg tgctgattgc tgagatgtca gaccgtttgt atattggctg 1124221 agcaaagaac tgaaacttga aagcgggctt tccgtattct gagtgtccga gctgctgcgt 1124281 gcattagata tggactgtaa tgcctgaagc tgaagtaatg ctgcccaatt cgttacattc 1124341 acgatgtcat tccaccttat atagactttc gtttttcttc ataaaaacgc agaattttat 1124401 ttttggtttc gcgctgagga atgctgaatt gctgaagcag cttttcgaag gcttgtctgc 1124461 cctcatgcca atccgccgcc tcaaattcaa tttcatagtc ctctttattt aaatatcggc 1124521 tgtggtctaa aactattaag cctttttctg tttctttttc cgcacggttt gttgctaaag 1124581 atccaaagta ttgtatggca tccgtatcga tctgaagctt gtgcagctgg tccttcacag 1124641 ggccctcggg aactgaaaat ccagcgagat ctgatacctc tgaaagctgc tggtgcgttt 1124701 ccagaagccc cacatcagcc ggctccttta atgtaaggac atactttccg ttttttctgc 1124761 ggatacgaag cgcagcatgt ttttgtttca gcgcgaagct gtctgtatca aaataatgat 1124821 tcttttgatc tgtaaaatct ttttctgtca gctggagtgc cgatgctatg tttttgaatt 1124881 cttgtttggt cagcatgttt ttaaattcga tttcaatctc ttggctcatg atgctcttcc 1124941 tttccgccct gtaaatctta tttttactat tatctcttta gatgttaggt ttatcaatat 1125001 cgagctcgat atgataaaat gaatctgtac tttgtttaaa aaaggagagc attatgcaaa 1125061 acagaatcga aattttgaat gcaacattat cggatgatca gcttcgcctt gcctgtcaga 1125121 cagaaggaaa cgaagcggaa cgcaagccgt caggtcaaat gcttgttgat tctgaccact 1125181 ttgcttttgt atacatactt gaattagctg attcttttga atatgtcatt ataaaggaac 1125241 atgtatggcc ggaactgaag caggcccatg cacaaaaaat accggttgtt ttagaggcag 1125301 gagaccaaac aattgaactg gcaggcctgc atgaggagct ggaatatctt ttagaaaata 1125361 taaaagataa tgcaaactat ggagaagaaa tggaagaaaa agtgaaacgc gtgtttttat 1125421 agaaactggt tcggaattgg gggatgtatg atggatgaca aacaatggga gcgtttttta 1125481 gtgccgtacc gccaggctgt cgaagagttg aaagtgaagc tcaaggggat ccgcacacta 1125541 tatgaatacg aggacgacca ttcaccgatc gaatttgtga ccggacgcgt caagcctgtg 1125601 gcgagcatac ttgaaaaagc gagacggaaa agcataccgc tgcatgaaat tgaaaccatg 1125661 caggacattg ctggccttag aatcatgtgc caatttgtcg atgacatcca aatcgtaaaa 1125721 gagatgcttt ttgccagaaa agatttcacc gttgtggatc agagggatta tattgcggaa 1125781 cataaagaga gcggataccg atcataccat cttgttgtgc tgtacccttt gcagacggta 1125841 tccggagaaa agcatgttct cgtagaaata cagatccgta cactggcgat gaatttttgg 1125901 gcgaccattg aacattcatt gaattataaa tacagcggaa acattcctga aaaagtaaaa 1125961 ctaaggcttc agcgcgcttc tgaagcggct tcccggcttg atgaagagat gtcggagatc 1126021 aggggtgaag tacaggaagc tcaagctgcc ttttcaagaa agaaaaaagg aagcgagcaa 1126081 caataggtaa aggggaagaa gagcatgaaa tttgccgtat catcaaaagg agatcaagtt 1126141 tctgatacgc tgaaaagcaa aatacaggcg tatttattgg attttgatat ggaactggat 1126201 gaaaatgaac cggaaatcgt tatttcagtc ggaggcgacg gaacgctttt gtatgctttt 1126261 cacagataca gcgaccgttt ggacaaaaca gcatttgtcg gcgttcacac aggtcatctg 1126321 ggtttttatg ccgactgggt tcctcatgaa attgaaaaac ttgttcttgc catcgcgaaa 1126381 acgccgtatc atacagtcga atatccgctt ctcgaagtca ttgtgaccta tcacgaaaac 1126441 gagcgggaag aaagatactt agctttgaat gaatgtacga ttaaaagcat cgaaggaagc 1126501 cttgttgctg atgtggaaat caaagggcag ctctttgaaa ccttccgggg cgacggcctc 1126561 tgcctgtcaa ctccatcagg cagcacagcc tacaataagg cgctgggcgg agcgattatc 1126621 catccgtcta tcagggcgat ccagcttgcg gaaatggctt caattaataa ccgcgtgttc 1126681 cgtacggtcg ggtcacctct gcttctccca tcccatcatg attgcatgat taagccgaga 1126741 aacgaagttg actttcaagt gacgattgac catttaaccc ttctccataa ggatgtaaag 1126801 tcgatccgct gccaagttgc atccgaaaaa gtgcggtttg cgagattccg tccgtttcca 1126861 ttttggaaaa gagtccagga ttcgtttatt ggaaaaggtg aatagaaaga ggacatatcg 1126921 tggagcattt ttttatcaga aagaacatta cttccgctga ggacgggatg actgtaaaag 1126981 aatatgccgg tgaactggga atttcgaaac gtctgctgac cgatattaag tttggcgggg 1127041 gagacctgca gattaacggt gagcatgtga cggtcaaata cgttttgaaa gagggagatc 1127101 ttcttatcgt gaagtttcct gaggagcagg tgagcgagac gctgttggca gagcctgttc 1127161 cgctcgatat cctttatgag gatgaacatg tgcttgtgat aaacaagcag ccgtatgtgt 1127221 catcaatccc ttcgagagag cacccctccg gcagcattgc caatggaatt attgatcatt 1127281 atcaaacaac cggagtgagg gcgacagttc atcttgtcac ccggttagac cgggatacat 1127341 caggtatcat gcttgttgcc aagcatcgat ttgcccactc cattttatcg tctgcgcaaa 1127401 aaaacggcct tgtgaaacgc cggtatgcgg cagtggttca cgggcggatg gcacagatgg 1127461 agggaacagt cgatgctccg attggcagac atcctgacag tattattgaa cggacggtaa 1127521 cgccagacgg ccagaaggct gttactcatt tttacgtcac atgtgcaaat gatgacatga 1127581 cctcggtggc attgcagctt gagactggac gaacccatca aattcgtgtt catatgagct 1127641 atctcgggca cccgttgtgc ggcgatacac tgtacggcgg aacgagacag gaaattggcc 1127701 ggcaggctct gcacagcgag catctttcgt ttatccatcc gctgacacag gagaacatga 1127761 ggtttcatgc tccactgcct caggacatga gcaaactgat aaaaggagag aatcattgat 1127821 tctctccttt tttatatggg gcgaaatctt gattcgtcgt aaggcaggga gcttggaaca 1127881 gagacggttt ctatttctgg aaagcgaaag cctgtcagtt gatttccgaa cacgcagcct 1127941 gtatcaatgt tgatggtgcg attgaccttc cgaggctctt tcacaggtgt atgaccgtat 1128001 accacccaag cctttccgtt ataggctgcc gcccaatcac gcctgatggg tctgccgtcc 1128061 ggatatgttt cacccgtcac gtcaccgtaa agcacaaagt ccttcactct gcgggtatat 1128121 ttgccgatat cgtcagctct tatgccagca tgggcgacaa ctaattctcc attatgtaag 1128181 atgtcgtaaa gcggcgctgt ttcgtacagc ttcataaact gttcgctgac tgattttttc 1128241 tcatctttgg aaagttcctc aagctctgcc gctgttgttt cgagaccatg catcactttt 1128301 accggatttc cttttaagta acgatataat ttattgcaat ggtttcccgg gacataacgc 1128361 acagcgcctt tttcgtaagc gccggctaca aatcggatga cctctatcga tttgggccct 1128421 ctgtcagtta aatctccggc aaaaacaagc accctgcctt cttcatggac aggtactcca 1128481 tttttgattg tatagccaag cttttggatt aatgcagtca tttcgtcata gcagccatga 1128541 atatcgctga tgatatcgta agccatgcgg tctcctcctt accgattgtt ttatttatta 1128601 tgaagcaaag tgttgtgagt catcacaagc ttttatgtgc aaattataga agaagaatca 1128661 ttttctaaac aggattaaga ccttatcact ttatttttca tcatcaccct tgttaaaatc 1128721 gcgttatgtt ttttaaaaat gaggttttgt tctctgagtg agaactagca taaccctgac 1128781 ttaaaaagga ggttctgatt atggcgcata catctgtcgc atctttagtt gttgtactta 1128841 tcgttgcatt tttgacaccc atccttttgc atcggtttaa actcagcatc ccggttgttg 1128901 ttgctgaaat cattatgggg ctgataattg ggaaaagcgg ccttaattta gttgtggagg 1128961 gtgacacctg gctccagaca ctctctatgc tcggatttat ctttttaatg tttttaagcg 1129021 ggcttgaaat tgatttttcg tcgtttgaga aaggaaagaa aaagcagttc ctgccgaatg 1129081 gcaaggaagc gccgaatacg tttgctgcgg catctgttat tttcgtcggt atttttattt 1129141 tatcattgct cttgtcctat gggttcgtct tggccggatt tatccaaaat gcatttttga 1129201 tgaccctgat tatttcaacg atttcattag gcgttgtcgt tccaacatta aaagaagaac 1129261 ggatcatgaa ttcgaatatc gggcagatta ttttgcttgt tgctgttatt gctgatttgg 1129321 ccacgatgat tcttcttgct gttttttctt ctttatacgg agaggacagc ggaaacatgt 1129381 ggctcctgat gattctgttt gcggccggag tggtgcttta ctttttcggc cgggtcttca 1129441 aacatcgctc ttttgttcaa tccatgtcaa aagggacgat ccagatcggg acgcgtgcca 1129501 tttttacgtt aatcattgta ctcgttgccc tgtctgaatc acttggggcg gaaaatattc 1129561 tcggcgcttt cttagcgggg gttcttgttt ccctgctttc gccaaacaaa gaacttgttc 1129621 agcagctgga ctcattcggt tatgggttct taataccgat tttcttcgtg atggtcggtg 1129681 tgaagcttga tatttggact cttttccagg ataaaacaat tttaatcatg attccgctcc 1129741 tgctgcttgc gctgttagtc agcaaaatca ttcctgtcat gtacttaaag aagtggtatg 1129801 ataaccgaac cattttcgcg tctggtttcc tgctgacatc aacgctttcg ctcgtgattg 1129861 ctgctgcaac aatcggccag cagcttcacg tgatcagtac aaatatgtca ggagcgctaa 1129921 ttttagtagc cgtcattgca agtattttta cgccgatctg ttttaaaaaa ttatacaaac 1129981 gggaagagca gccggaggag aaaaagacga ttacgttcat tggcgccaat caaatgactt 1130041 tgcctgtcac actcgaattg ccagaggaag agtatgacgt gcgtgttgta cacgtctacc 1130101 aagagaatgc ggaggaaaag ctgtcagaat cagtgtttgc tgttgaaaca atttctgact 1130161 atgaacacga gacgcttgaa tcactcggca tttttgaaac ggatatcctc gttgtggcga 1130221 caggaaatga agatatgaat gcagacattg cattacttgc aaaagataaa ggcacagaaa 1130281 gagtcattgc aagcgtagga tcaccggagc atgaagcagc tctgaaggag cagggaatca 1130341 gcatcttttc tattctgctg tcgacaaaaa cgctgcttcg cgcactgatt gaagcgcctg 1130401 gcgtcatgaa gctgctcacg aaccaagagt cttcgctgta tcaaattaat atggagaaca 1130461 gtaaatatga tggtgtcatt ttacgggaat tccctttaac aggtgacgtc atctttgtca 1130521 ggatcttcag aggtgtggac agcatcgttc ctcatgggga tacgaggctg aaacttggag 1130581 accgtttaat tgtcaccgga tctcgggggt acgtaacgga tcttaagaaa acattggaag 1130641 gataaatctt gaccaaataa ggattcgtgt taatatagag gtgcagaaca attcaatatg 1130701 tattcgttta accactaggg gtgtccttca taagggctga gataaaagtg tgacttttag 1130761 accctcataa cttgaacagg ttcagacctg cgtagggaag tggagcggta tttgtgttat 1130821 tttactatgc caattccaaa ccacttttcc ttgcgggaaa gtggtttttt tattttcaga 1130881 gggggaatga tttgtgaagt tttcagaaga atgccgcagt gcagccgcag aatggtggga 1130941 ggggagcttt gtccatccgt tcgttcaagg aatcggtgac ggaacgcttc cgattgaccg 1131001 ttttaaatac tacgtacttc aggattccta ttatttaacg cattttgcaa aggtgcagtc 1131061 atttggtgcc gcttatgcga aggatcttta tacaacgggg cggatggcaa gccatgccca 1131121 aggtacatat gaggcggaaa tggcgcttca tcgcgagttt gccgagctgt tggaaatcag 1131181 cgaggaagag cgtaaggcgt ttaagccgtc tcctacggcg tactcttata catcccatat 1131241 gtaccgttcg gttttgagcg ggaatttcgc agaaatctta gcggccctgc tgccatgcta 1131301 ttggctctat tacgaggttg gtgagaaatt gctgcattgt gatccggggc atccaattta 1131361 tcagaagtgg attggcacat atggcggtga ttggtttaga caacaggtcg aggagcaaat 1131421 caaccgcttt gatgagctgg cggaaaacag cacggaggaa gtgcgtgcca agatgaaaga 1131481 gaattttgtc atctccagct actatgaata tcaattttgg ggaatggcct atcgaaaaga 1131541 aggctggtct gacagcgcca taaaagaggt ggaggaatgt ggagcttcac gccataacgg 1131601 atgacagcaa gccggtagaa gagctagcga gaatcatcat tacgattcag aatgaagttg 1131661 attttattca cattcgggaa cgctcaaaat cggcggcgga tattttgaaa ctgctcgatc 1131721 ttatttttga aggcggtata gataaacgaa aattggtgat gaacgggcgc gtggatattg 1131781 cacttttctc tactattcac cgcgtgcagc tgccaagcgg cagcttttca ccgaagcaga 1131841 tcagagccag atttccacac cttcatatcg ggaggtcggt gcattcactg gaggaagcgg 1131901 ttcaagcaga aaaggaagac gcggactacg tgctgttcgg ccatgtgttt gaaacggatt 1131961 gcaaaaaggg tcttgaaggc agaggagtat ctttgctgtc agatatcaaa cagcggattt 1132021 ccatcccggt tatagccatc ggggggatga cgccggacag gttaagagac gtaaaacaag 1132081 caggggcaga cggcattgct gttatgtcag gaattttctc ttccgctgaa cctttggaag 1132141 cagccagacg atattcccgc aagctaaagg agatgcgcta tgaaaaggca ttatgaagca 1132201 gtggtgattg gaggcggaat tatcggttcc gcaattgctt attatttggc aaaggaaaac 1132261 aaaaacaccg cattgtttga aagcggaaca atgggcggca gaacgacaag tgccgctgcc 1132321 ggaatgctgg gcgcccatgc cgaatgcgag gaacgtgacg cgttttttga tttcgctatg 1132381 cacagtcagc gtctgtacaa aggtcttgga gaagagcttt atgcattatc cggtgtggat 1132441 atcaggcagc ataacggcgg tatgtttaag cttgcatttt ctgaagaaga tgtgctgcag 1132501 ctgagacaga tggacgattt ggactctgtc agctggtatt caaaagaaga ggtgttagaa 1132561 aaagagccgt atgcgtctgg tgacatcttt ggtgcatctt ttattcagga tgatgtgcat 1132621 gtggagcctt attttgtttg caaggcatat gtgaaagcag caaaaatgct tggggcggag 1132681 atttttgagc atacgcccgt cctgcatgtc gaacgtgacg gtgaagccct gttcatcaag 1132741 acccctagcg gagacgtatg ggctaatcat gttgtcgttg ccagcggggt gtggagcgga 1132801 atgtttttta aacagcttgg actgaacaat gcttttctcc ctgtaaaagg ggagtgcctg 1132861 tccgtttgga atgatgatat cccgctgaca aaaacgcttt accatgatca ctgctatatc 1132921 gtaccgagaa aaagcggaag actggttgtc ggcgcgacaa tgaagccggg ggactggagt 1132981 gaaacaccgg atcttggcgg attggaatct gttatgaaaa aagcaaaaac gatgctgccg 1133041 gctatacaga atatgaaggt ggatcgtttt tgggcgggac tccgtccggg aacaaaggat 1133101 ggaaaaccgt acatcggcag acatcctgag gacagccgta ttttatttgc ggctggccat 1133161 ttcagaaacg ggatcctgct tgctcccgca acgggcgctt tgatcagtga tctcatcatg 1133221 aataaagagg tcaaccaaga ctggctgcac gcattccgaa ttgatcgcaa ggaggcggtt 1133281 cagatatgat gctacagctg aacggtaaag acgtgaagtg gaaaaaagac acaggtacaa 1133341 ttcaagacct gctggcgtcg tatcagcttg aaaataaaat cgttatcgtg gaaagaaata 1133401 aagaaataat cgggaaagaa cgctatcacg aggttgagct ttgtgatcgt gatgtcattg 1133461 aaattgtcca ttttgtagga ggcggatgag catgttaaca attggcggaa aatcatttca 1133521 atcaagattg ctgctgggca cggggaaata cccatcgttt gacattcaaa aggaagcagt 1133581 agctgtttct gagtctgata ttttaacatt tgctgtaagg agaatgaaca tttttgaagc 1133641 atctcagccg aattttctgg aacagcttga tttatccaaa tatacgcttt tgccgaatac 1133701 agcgggcgcc agtactgctg aagaagcggt tcggattgca aggctggcga aagcttcagg 1133761 cctttgtgac atgattaaag ttgaagtcat cggatgcagc cgttccttgc tgcctgaccc 1133821 tgttgagaca ttaaaagcgt ctgaacagct tcttgaagaa ggctttattg tgctcccgta 1133881 cacgtcggat gacgttgtgc tggcgagaaa gctggaagag ctcggcgttc atgccatcat 1133941 gccgggtgca tctccgattg gatcaggaca aggaatctta aatcctttga atctgtcgtt 1134001 tattattgaa caggcgaaag taccggtcat cgtggatgcg ggaatcggct cgcctaaaga 1134061 tgcggcatac gcaatggagc ttggagcgga tggcgtactg ctcaatacgg ctgtatctgg 1134121 cgctgacgat cccgtgaaaa tggctcgtgc catgaagctc gcagtggaag cagggcgcct 1134181 ttcttatgag gcgggccgaa tcccgcttaa gcaatacgga acggcaagca gtccgggaga 1134241 aggtcttcct gtatgacagg caggtattca aggcaggagc tgtttgctcc gatcggccca 1134301 tccggccaga aaaaattgaa agaagcgcgc gccgtgatta tcggcgccgg cgcgctcgga 1134361 acagccagtg cagaaatgct ggtgagagcg ggagtcggct ctgtgaaaat tgccgacaga 1134421 gattatgttg aatggagcaa cctccagcgc cagcagcttt atacagaaga tgatgtcaaa 1134481 aaagaaatgc cgaaagcagc cgctgcggag cgccgtctcc gttcgattaa cagcgatgtt 1134541 gatgtgaccg gccttgtcat ggatgtgaca gcagaaaata tcttcgagct gattagggat 1134601 gcatcgatta ttgtggatgc ggctgataat tttgaaaccc gcctgatcgt aaatgatgct 1134661 gcggtaaagg aagggattcc ttttctttac ggtgcctgtg tagggagcta cggtcttacc 1134721 tttaccgtgg tgccgggttc tactccttgc ctgcattgct tgctcgatgc acttccgatt 1134781 ggcggagcaa catgtgacac agctggcatc atcagtccgg ctgttttgca ggtagcagtc 1134841 tttcaggtaa cagatgcact gaaactgctg acgggagagg agtgcgagcc ggtgctgcgc 1134901 tcctttgatt tgtggaaaaa cgagcggtca gaagtgagag cggccagtct caaacatgac 1134961 gcatgcccaa gctgcggcac aaaggatttt ccgtttttgt cttatgaaaa tcaaacaaaa 1135021 gcggctgtat tgtgcggcag gaacacggtg cagatcagat catctattac gaaagaagcg 1135081 gatcttgaag cgcttgccgg tcagctgagg caggccgggc ttgaagtagc tgcgaacccg 1135141 tatttaattt cctgccgctc ggatgatatg aaaatggtgc tgttccggga cggcagagct 1135201 ttgatccatg gaacaaatga tattgcccgg gcaaaatcca tttatcataa atggattggg 1135261 taataaaagg agtgtagtgt aatgagtata tataaagcat tgacaatcgc cggatcagat 1135321 tcaggcggcg gcgcagggat acaggctgat attaaaacct ttcaagagct tgatgtattc 1135381 ggaatgtctg cgattacggc ggtaaccgct caaaatacgc ttggcgttca cggggtgcat 1135441 ccgctgactg tagagacgtt gagacagcaa attgacgctg ttgctgagga tttgagaccg 1135501 gatgcagtta agacgggaat gctctggaat gccgacatga ttgaagaagt ggcaagaaaa 1135561 attgacgagt acggattcaa tcgtgtaatt gttgatccgg ttatgatcgc aaagggcggg 1135621 gcatccttgc tgcgtgatga gtcagttgcc accttaaagg agttgctcat tccaagaagc 1135681 tacgcgatta cgccgaatgt cccggaagca gaaacgctga caggaatgac aatcagctcg 1135741 ctggatgacc ggaaaaaagc agcggagcag ctcgtcaaga tgggtgcgca gcatgtcatt 1135801 atcaaaggcg ggcaccagcc tgaggacaat cacattactg accttctttt tgatggcagc 1135861 atgtttatgc aaatcaccca tccttatatc aatacgaagc atacgcatgg cacaggctgc 1135921 acctttgctg cggctttaac ggcccaaacg gctaaaggag acagcatcca tcaggcattt 1135981 gaggttgcgg ccaactttgt ccgtgaagcg gtggaaaata cgctcggcat cggatcggga 1136041 cacgggccga caaaccattt cgcttttaaa cgaaacagct taaatacaag ccgatgagat 1136101 caccagctga tggtgatctc ttttgcgttt gctacggtat gcgcttttca tctggacaag 1136161 gttatgatat gataggaatt aagatcaggt actaatacta tgtctttatt aaatatagga 1136221 ggctttatac atatgaattt ttcacttgaa ggccgtaaca ttgttgtgat gggggtagcc 1136281 aacaaacgca gcatcgcctg gggcattgcg cgttctttac atgaagcggg tgcacgtttg 1136341 attttcacat acgctggtga acgcctggag aaatccgttc acgagcttgc cggaacatta 1136401 gaccgcaacg attccatcat cctcccttgc gatgttacaa acgacgcaga aatcgaaact 1136461 tgcttcgcaa gcattaagga gcaggtcggt gtaatccacg gtatcgcgca ttgtatcgcg 1136521 tttgccaaca aagaagagct tgtcggcgag tacttaaaca caaatcgtga cggcttcctt 1136581 ttggctcata acatcagctc atattctctg actgctgttg tcaaagcggc acgtccgatg 1136641 atgactgaag gcggaagcat tgtcactttg acgtaccttg gcggagagct tgtgatgcca 1136701 aactacaacg tcatgggtgt agcaaaagct tctcttgatg caagtgtgaa atatttagct 1136761 gctgacttag gaaaagaaaa tatccgcgtc aacagcattt ctgccggccc gatcagaaca 1136821 ttatctgcta aaggcatcag cgatttcaac tctatcttaa aagacatcga agagcgtgca 1136881 ccgcttcgcc gcacgacaac acctgaagaa gtgggcgata cagctgcgtt cttgttcagc 1136941 gatatgtccc gcgggattac aggtgaaaat cttcacgttg attctggttt ccatatcact 1137001 gcccgctaag caggctgtta atgatgcaag ggctgtcttg ctttctgtag caggggatac 1137061 aaaaatcttg agcggttggc tgttttgccg cgcctgttag cagggcaaga caaatataaa 1137121 tgctgtttcg cccgggtcat ggctacatat aaaaggcgtc tttcctcctc aagagcggcc 1137181 tcgtctcctt ttcttgccgt ttctaatgag aaatcgtgcg gaatcgagcc atctacagtg 1137241 cctaacacgt agactgtttt gaattcaagg ccttttgacc ggtgaatggt catcagctga 1137301 acgccatgtt catccgttct gtttttctca gcggccctca tatggtctac gtgggcaaga 1137361 aagtcaggaa tcgttttgaa cttcttggcg acaaccttga tgtcgcgcag gtcatcagag 1137421 cctttttcca gcttgttgcc ctcattgccc cgctttttta aatactcgga gaagcccatt 1137481 tttccttctg caaaggtgat ggcttctacg ggtttcattg tgcggaggct tgcaaaaaac 1137541 ggtacgattt tcttgatttt gtccagctgg aatggcttca gatcaggcaa tttggccagc 1137601 gctttgatca tggtacagtc ctctgtaatc gagagcgcct tcagcgtatt caaagcggac 1137661 tgttttaaaa acaaggcggg aagcaagtgt ttaatcgcct cggtgtcatc ctcattttgg 1137721 ctggcgtaca agtaggcgag aatctggcgg acgatccgtc tgctgtaaaa cgattggacg 1137781 ccgcggtcag ctgtatacgg aattgacgat tgatgaagcc tttcatatat agcacggcct 1137841 ccgctgtttg tgcggtaaag aaccgcaaag tcttctggac tggctccatt ttgaattttt 1137901 tctttgatat cggaaacgac cattgtggct tcttcctctt catcataagg ataaaacagc 1137961 acagggacct gaatgtcatc gcgggccgct tcaagcgttt tggcatatct gtttttgttc 1138021 tttttcacaa cgatatcagc actagagacg atcgggtgcg tagacctgta gttcgcagtt 1138081 aaatagatcg tcttcgctcc cggataatcc ttttgaaaat caagaatgaa agacggattg 1138141 cttccgcgaa acgcgtagat ggactggtca tcgtctccga cacagcacag gttttgctcc 1138201 gggctggcga gcatttgcat gattttgtat tgaaccggat taatgtcctg aaactcatca 1138261 attaagatat acgtaaaccg agattgatat tgttccagaa ggtcaggccg ctcgataaac 1138321 aattcatagc aggctgaagc catgtcatca aaatcaaatt ggctgtgttc ttttttctgg 1138381 cgttcataat gttcatataa acgataaact tgtttttccc actcatcttt tagagggatg 1138441 cgttcatttg ggacataagt gtttttccaa aaaccgatct gctgcagggc ttggtcaact 1138501 ggggattctt tctcatcgat gccttcttca tagagtgctt ttttgatata ttgttcccgc 1138561 tgccactcca ttttcagcag atgctcaccg ttccatttag cagaattaga gtgatacaag 1138621 atcttataaa acagactgtg gaatgttcct gtcacaattc ttctgacttt tgccggctgt 1138681 aatccgtact ggttcgccat acgctctttc atttcagcga cagcttttgt tgtaaaggtg 1138741 acaagcagca tattttcagg cggtatgcct aagtgttcga tcatgtgggc ggcacgggct 1138801 gtcagtaccc gtgtttttcc gctccccgca cctgcaagca cgaggagcgg gccctctgtt 1138861 tccgtgacag ctttcagctg atccgtgttt aaaccgacag acggaaaaag gctcgtatcg 1138921 ggttctattg tttttggcac aaatggtgtt cctggtttaa tgcttctagg acggtgccat 1138981 tctgtaacag ctggggacgg gtcagcggcg atcgcttttc ccttgggtaa acgaatgaca 1139041 ccagattcct gatcatcttc ttttttcccc tctttagagg gcttcggttc gcacgcctcc 1139101 tcacatgccg gaaaatcgcc tggctggcga tggataaact ctggcggatc ggcgatgtta 1139161 agccgtaaca aaacgggctt tccgcaatga gaacaaaata aatgtccttt tattccctct 1139221 tcaaagagga attgataatg ttctctcgaa tatgtatgta aatgtatgat tctatcattc 1139281 agtcgggcgc atttcaaaaa ggggtcctcc caatcaaaag gtgttcatta cagacaatga 1139341 ctatcatatc aaaagaaatg tgtttcaaaa agtaagttta agggaaaaga gacagcagag 1139401 gggtgggtat tgtatgatat atgcaggtca aattcagaac cagcaatacg ctcaatatgc 1139461 taatagaacg attggacata agcaggatta tgccggaacc gaaaaaatca gctatgtccc 1139521 gtttcagcgg gtatacaaag aactggaaaa gcagcaggag aatcaaacgg cagctgaaag 1139581 aaaagtaaac gagatgaaac gtaagcgctc tctttataag agattgcgag aaaaaggaat 1139641 ggggacatat attaatcgat atgtataaaa aaccgttcat accagagaac ggttttttta 1139701 tatgcagtaa aaatccggat ctcaaaagat ccggatgcgt tcagtccttc atcatttgta 1139761 agtgcggaat gccggcatcg aggaattctt tttcagaaag cacgcgatac ccgtgtttct 1139821 tgtaaaacgg cacagcctgt gtttgcgcgt ttaaaatgaa accggaagcg cctccgtctg 1139881 ccgcggcttt ttcgagcgct ttcataatga tgccgccgac accggctgag cggtggcttt 1139941 tcagtacgca aatccgctct aacttgccgt agccgtcctt catgcgccat cttccggcac 1140001 cgacaggctt ttcaccgtca tacacgacga tatgctctga ctcattttca agttcgtcaa 1140061 tttcttcttc agcaggcacg ttttgttctt tgacaaagac ttcttctctt acatagaatg 1140121 catctttcag ttgttcttca ttttttgcga taactgcttt caaacattat tctcctctgc 1140181 ctagcaagaa ggtttcatat actgtccacg atccgttttc caactggtag agcaagtgga 1140241 aacggtcaac gatttcttca tgcgacactt cctgcatttt taattgtccc agcacatctg 1140301 aatgctcatc gtcggaaaga ttttggccga ccgtcacatg cggaacgaaa ttatattcct 1140361 gttctcctgc caacacaccg gtgtatagct tttcattgag tgtttttaac tcttccgtcg 1140421 gttctgcttt gatgtaaatg acattattga caggcgcaaa tgagctgtat tttgtcattt 1140481 tgagaacgag tgggtgggac tcttttgcga tgtttcttaa atgtgatacg agctgatccg 1140541 ctttctcctc cgcgcattca aaggatgctc tcagcgtcaa atgaggcggg attagagagt 1140601 agcttgggtc atagcgcttt ctgtaagagt ttgcaaggtc ttggagcttt tttgatggaa 1140661 ataaaacgat tccgtatttc atattatgtc cctcctggaa ataaagtatg atagagtgtt 1140721 aaagcatttt tttcagcgcc ggggtgatga gcggctgcca gtatgtccat ttgtggtctc 1140781 cgtcaaatgg ctcgaaatca taatcggaaa gctttttctc cagcagctgt ttcagctccc 1140841 ggttcggttc tgtaaagtcc agaatgttcc cgtctgtcgt gtggacgtca gtttcttttg 1140901 ttccgatttg gtgataaata gagaggtgtt tgatatcgtc tgactgtttt acggcttcta 1140961 gtacgtgttt gtcaacatag ggagactgca tgatgatgtt gccaaacata ttcggataat 1141021 caagcgctgt cataagtgac acggttgctc cgagcgaatc accgatcagc gttcggccgt 1141081 aaccgatctg ataggttgga tactcatcat ctgcaaaagg aacgagctca tgggcgatga 1141141 accgtttata agccgaaaat tttgaaccct ccggatgata agtgtttctg cgctctttta 1141201 catccttata gggaacaccg ataataatgc tccggtctat ttcgcgtttc gacagcaatt 1141261 cctcaacctg tctgccgatt ctccccagcc tgaaataatc gtggccgtcc tgcgcgataa 1141321 tgacatggta tttataaagc ggggagtagt tggacggcag ataaacaagc aaggtcattt 1141381 cctcgttaag ctcttttgaa aagaatttct tttcttgcac tgtgccgttt ttcggtgcca 1141441 taaaaacatt cctccaggac atcactatac tttcttgcat tttcaattat tgtaccatga 1141501 attattagaa atttctctct ttaaacggtt cggcacacga agaaaaaagt gttgaaataa 1141561 actgtgaatt gcgctaatat aaaacaatca gaaaattgaa atcgatattt cttatcgtga 1141621 gaggtggagg gactggccct tagaaacctc agcaaccggc ttgttttgca tttgcaaagc 1141681 gccaaggtgc taaatccagc aagcgttttt tatgcttgga agataagaag aagcgttaaa 1141741 ccccttcttc ttatgaagaa ggggttttta ttttgaaaag ggaaggtgtc agctatatgt 1141801 cacagcacgt tgaaacgaaa ttagctcaaa ttgggaaccg tagcgatgaa gtcacgggaa 1141861 cagtgagtgc tcctatctat ttatcaacag cataccgcca cagagggatc ggagaatcta 1141921 ccggatttga ttatgtccgc acaaaaaatc cgacacgcca gcttgttgag gacgcgatcg 1141981 ctaacttaga aaacggcgcg agagggcttg cctttagttc gggaatggct gctatccaaa 1142041 cgattatggc gctgtttaaa agcggagatg aactgatcgt ttcatcggac ctatatggcg 1142101 gcacgtaccg tttatttgaa aatgaatgga aaaaatacgg attgactttt cattatgatg 1142161 atttcagcga tgaggactgt ttacgctcta agattacgcc gaatacaaaa gcggtgtttg 1142221 tggaaacgcc gacaaacccc ctcatgcagg aggcggacat tgaacatatt gcccggatta 1142281 caaaggagca cggtcttctg ctgatcgtag ataatacatt ttatacaccg gtcttgcagc 1142341 ggccgcttga gctgggagct gacattgtca ttcacagcgc aaccaagtat ttaggcgggc 1142401 ataacgatct gcttgctgga cttgtcgtgg tgaaggatga gcggctcgga gaggaaatgt 1142461 ttcagcatca aaatgcaatc ggcgccgtcc tgccgccatt tgattcgtgg cttctgatga 1142521 gaggaatgaa gacgctgagc ctcagaatgc gccagcatca ggcaaacgcg caggagcttg 1142581 cggcgttttt agaagagcag gaagaaattt cggatgtgct gtatcccgga aaaggcggca 1142641 tgctgtcctt ccgtctgcaa aaagaagaat gggtcaatcc gtttttaaaa gcactgaaga 1142701 ccatttgttt tgcagaaagc ctcggcgggg tggaaagctt tattacatac cctgcgaccc 1142761 agacgcacat ggatattcct gaagagatcc gcatcgcaaa cggggtgtgc aatcggttgc 1142821 tgcgcttttc tgtcggtatt gaacatgcgg aagatttaaa agaggatcta aaacaggcat 1142881 tatgtcaggt caaagaggga gctgtttcat ttgagtaaac acaattggac gctggaaacc 1142941 cagctcgtgc acaatccatt taaaacagac ggcggaaccg gggcagtcag tgtaccgatt 1143001 cagcacgcct cgacttttca ccaatcttca tttgaagagt tcggggcata tgattacagc 1143061 cgctctggca cgccgacaag aacagctctc gaagaaacaa ttgccgcact ggaaggcgga 1143121 acaagaggat ttgctttcag ttcaggcatg gctgccatct caacagcatt tttactgctg 1143181 tcacagggtg atcacgttct tgtgacagaa gatgtatacg gcggaacctt ccgtatggtg 1143241 acagaggtgc tgacccggtt tggcattgag catacgtttg tcgacatgac ggatcgtaat 1143301 gaagtggcgc ggagcatcaa gccgaacaca aaggtcattt atatggagac gccatcaaat 1143361 ccgacacttg ggattacgga tattaaagca gttgttcagc ttgcaaaaga aaacggctgc 1143421 ctgacctttc tggacaatac attcatgacg ccggcactgc agcgtccgct tgatctcggc 1143481 gtggatattg tacttcacag cgcgacaaaa ttcttaagcg gacacagcga tgtgctctca 1143541 ggtttggctg ctgtcaaaga tgaagagctt gggaagcagc tgtataagct acaaaacgcg 1143601 ttcggcgccg tccttggcgt gcaagattgc tggcttgtcc tgcgcggatt aaaaacattg 1143661 caggtccgtt tagagaaagc gagtcaaaca gctcagcggc ttgcggaatt tttccagaag 1143721 cacccggcgg tcaagcgcgt gtattatccg ggactggctg atcatcccgg cgctgaaacc 1143781 cataaaagcc agtcaacggg agcgggcgcc gtgctatctt ttgagcttga aagcaaagag 1143841 gccgttaaga agttagtcga gaatgtgtca ctcccagtct tcgctgtcag ccttggcgcc 1143901 gtggaatcga ttttgtccta tccggcaacg atgtctcatg cggcaatgcc taaggaagag 1143961 cgtgaaaaac gcggtatcac tgatggcctg ctccgtctga gtgtcggcgt cgaacatgca 1144021 gacgatttag aacacgattt cgaacaagcg ctgaaagaaa ttgctccagt ttcggttcgt 1144081 taaaaaagaa gccggggata gtccggcttc ttttattatt gttcgtcatc aggattcaga 1144141 atcgcgagga cttgatgatc ctcccaaacg ccattaattt ttacattttt tcgggcgatg 1144201 ccttctttat gaaatcccgc tttttctaaa acacgcatgg acccgagatt acggggcatc 1144261 acaccggctt caatccgatg cagtttcaat tcgtggaacg cataatcaac aaccaatctg 1144321 actgcctctg tcataatgcc ctttccatta tgggctttgt ctaaaaaata cccgatgaac 1144381 gcagtttgca gcgcgccacg gatgatttga aagagcgaaa ccgtcccgat taatctatcg 1144441 tctgacgctg taaagatgcc aaaatgatat tcttcatctt tctcaagtct ttcctgatac 1144501 tcggttattc gttttctttg cccctcaacc gtatagtaat cgtctgcgcg tatcatagaa 1144561 aactgttcga aaaaatctcg attttcgctt tgcagcccca gattttcttc ggcatccgtt 1144621 acttctaaag gtctaacata aatggttttt ccttttaaca tatagtgatc tctccgttct 1144681 catgtcagca ttcctcttac attattctca gggaaatgca aatatccttt ttataagaag 1144741 gaagaaaacc aatttcccat aaaagtgcca acatagttgc cgattaagta gccgagcgta 1144801 ccgacaagca tgatcggggc gacaagctcc cgccatccct tggcaattgc catcgcagcc 1144861 gcagtcgtcg gtcccccgac agtagcgttg acggcgagca gaatttcttc aagccgcaca 1144921 cggaacaatt ttccggcagc taaggaaacc gctaaattgc taatcgcaat gataaacacg 1144981 aataatagaa taagaggcgc attcgtgacg attaagcgga gatctgcagg aatgccgatc 1145041 accacaaaaa acaaataaat caaaaaggtt ccaagctcct gagatccatt gagcctttca 1145101 aaaaaacgcg ggaaaagaaa aatgataaga acagttaaag acgtaagaac caggtactga 1145161 tcgccaagcg taccggtcag caggggatga gaaaaaatgc ttttaaaata accggaaacc 1145221 ttcatactaa ccgcaacaag cgcgaaagcg gcaccggcat taaaagcgat atcctttaag 1145281 gaaatatcct tccgtttcca atagctttca gcactgtttc cgctgtttcc atcggctttt 1145341 accttctctt caaacggcat ggcataatgc cgctgaaacc atttgagtgc aggaatgctg 1145401 attaaaataa aaaacaaaag cgccatcata aaattatcag ccacaacggt agccgacaca 1145461 tattcaccag gcgtctcaaa ttttgccgcc atcgccgcaa agttgacccc gccgccgata 1145521 taagaggcgc tgatcatccc accgatttta tctaagtaag gaatatgctg tttgagtaga 1145581 aaaaaagcca ggatactgcc aagcactgtt ccaacggagc taatcagaaa aataaacagc 1145641 aaacgcctgc tttccttaaa aatttgccta acattgatct gaaacaataa aagtggtatc 1145701 gccagcggta ccacataaga ccacacagtg tcatacacgg gcgactcaac aggaagcact 1145761 cctacatttg taaacaccat agcacctgca agggcgataa tagcgcccga cacagcagac 1145821 gcccacttaa agcgctgctc cagcccgatg ctcactgccg cccacaccgc aataaacccc 1145881 cataataccc atacatcatc agaagaaatc aaagaatgca aaaccccatc acctctattg 1145941 ttagaaaatt aagacatatt ataatagccg gggaacggaa cagcaagtcc aaaaaaagtt 1146001 tttctaaaaa agcagttgac gaatagaagg taaggttata taatagaact tgtcagaaag 1146061 ataacaacat acccagcaac acatacatat catgattccg tagctcagct gggagagcgc 1146121 taccttgaca gggtagaggt cgctggttcg agcccagtcg gaatcatagc ttaaaccctt 1146181 gcgcagcaag ggttttttac tttgcgttaa taaagccggt tcgtcaaatt cgtgagttgt 1146241 tggcgaactg ttggcgaaat tcattgaccg cagtccaaaa actacctcca aacttacttg 1146301 attagttcaa tagtaacaaa cggaagatcg gatttctgtt aaatcttcat tgagaatagc 1146361 cagtccaaga ccgtcacttc agccatgcat cttttaaatg aaattttgta ctgaaaacat 1146421 caattgtatt tttaaattct gctctagaat cagccccttt ataataatct tgataaattg 1146481 cttggggtga tactgattcg tgatttgtgc tatggtttgc aaggcttgta gcaaaagcag 1146541 gagcaacagt aacgagtaaa gcaagggata atgcaaaacc agttaaagct ttttcaattt 1146601 cattttaagc acttcttttt ttaaaataca actttattat taaatggaat acaaaaacat 1146661 ccaaggtgtt tttttgttag taagttgagt tagggggatt ggatggcact tagaatattg 1146721 tttctgctga tgggatgttg attctggata tatttccaac acgattacag gccggacatg 1146781 aaagcgaacc ttgctttgat cggggcaatc atttcattta cggctgcggt ttactttaaa 1146841 gatattgatg tattgagaga agagggaaaa caaatgaacg gaatttctga gcgttggaac 1146901 acgtttaaat tacaaaaatc ccctgaacca ctctagatca ggggattgct ttcccaacag 1146961 cttattaagt agcggaaggc atgatcaacg atttagtatc aatttattaa ttgcgaatac 1147021 tagaaacata ccgttttccg ccttccttag aagtaacata ttctcgagga acattaagtc 1147081 tattggtaga atgataactt acataaagtt tcatatttgc tcggctcgtt acgatagccg 1147141 tatgatccat ccaaccatca gcatagcgaa gacctatttt attatggtaa tcatagtgat 1147201 atacatctcc aagctttaca tttgaatatg tatcagaaac agtcttcatt tttattccgc 1147261 cagcttttaa aatgtatgat ctaaaggctc ctgcattaac ccaagcatct gtatagggtt 1147321 tccattcttt aaagtacggc attcttccag ctcttaatgc ttgggaaaca aagttagtac 1147381 aatctttgtc tttataatat ttatagtttt tatttggttt taaggcatat ttttctgcat 1147441 atttcattgc agcgtaacca ctatatcctt taacagatgt tgcagtcaca gttagttgat 1147501 tagagttagc agcattgaag ttcatactta ctggtttatc ttcacttttc acttcttctt 1147561 tatcatcatt tttcacttct tgcttatatt tttttaaaaa ttcatctaat ttaacatccg 1147621 aagaatattc ttcatcattt tcatattgta gagttgaaga agaattattt aattgtgtta 1147681 catttagttg cttagaagaa ttactcaatg gtattacatt tagttgatta gaagaatttt 1147741 taacttgaga gaaacttaga ttagaagtat ttgttgattg agaactttgt ttattagaag 1147801 ttgttttggg aatttcaagt ttaatattat cgcccagaga tgttgttact ttttcaacac 1147861 caaaaacaaa gtttcgagta atataagctt caacaattag cttattgttt ttttcagaag 1147921 tcttaacatc gtctatatcg tatgtaaact cgtggaattt ttgtttgtcc actttactta 1147981 acgcagaata cagtaagact ccttcgtcgg aatcagtcaa tttagactct ttaggatgcg 1148041 ctaaaggagt gttgtgttca aaatcatatt tttgttgttc taacatatcc ttaacttttt 1148101 cgtaaccaat ctcgttggta attgaaacat tttctttagt ctctttatta gtagtggctg 1148161 caaaaacttc atttgttgac actaatggtg acaatgatag acataaaact agtgaagcaa 1148221 gtaattcttt tttcatacga aacctccaat aaaatctaaa tataagtaat atttatcatt 1148281 tacaccaatt gaaatatggc ataaaataca tgtaataata taacataaaa ataaatacat 1148341 aaaaaggtat cggaggaaaa aatgaaaaag aaaactaaaa ttatactttc tctcttggca 1148401 gcacttattg ttatattgat agtacttcca gttctatctc ctgttgtctt tacagcttct 1148461 tcggaaaaag gagcaatcag acacgaaatt tataaaagag gatatcccta ccaaagctac 1148521 tttgcagttc tccagaaaag agaaggagac aatgaatctg ggaatcttta ttatgtaaat 1148581 tggctagatt ggaaagatga aacagggcaa actcctcact tatgctattc gaaaaaatca 1148641 tcagatggtg aatacgaagt aagttgtggc acagggccgt aaaaataaat tttaaaattg 1148701 aataagtcca agacggaaag cctgcggaca ctgatcgttt tacagagaaa tttgtgcttc 1148761 gatcggtgtc cgtttttttt cgcaactaac cagatgtcta tcgcgattac tagctatgaa 1148821 aggagtaatt agacatgaaa cagtccaaaa agaaaccatc acagaagcaa catgagcgct 1148881 tagatcgttt ctggcaacaa atgatgaaca ctaacatgca aacactcaga cgtggcaaag 1148941 gcggcgctta taaacgcaga aagtaaaaag ggagtttgag gatgatgaaa aacggattcg 1149001 cttataaaaa cggaaagctt gtgaatatct tttgcggcaa agaagagctc tataacgagt 1149061 tgaaagcctt cttggtcaaa accttcagta tcaacgtgaa agaggtatcg aggccctcaa 1149121 tatatcgcag aacaaaaagc aaacaactgg aatgacactt actctattta actatcagga 1149181 gggaaagcac tatgacagat caaatgattg catgggagat tgaggaatgg attcgtgatt 1149241 ataaattcat gctgcgggag atcaaaaggc tcaaccgtgt attaaacaaa gtggatttta 1149301 ttagcacaaa gctcactgca acatacgggg aggaagcggg catgccaagg ggatcagcag 1149361 gcgtcagtca ggcagaattg cggcagatgg accgaagaga aaggcggctt cacaaatatg 1149421 aatctattgt gcattacctg gacaatgcaa tggaacacat tgaagaagaa aagcaccgaa 1149481 tcgtttacga ttgcatgatg gaaggcatga gctacactgc tattgcaaac caccttgatt 1149541 gctcccggga taccatcaga aagatcaaaa cagccataat cggcaacatc gtcaataaag 1149601 tcaaagaagc caactttctg caatatttga attcgtttaa atcggcggtg taaaatgggg 1149661 ggcaggatcg gcgcggcgga ttattcctgc gtcaccacca atttcataca atgagtaaaa 1149721 cctcccagtg gtaagcgagg atcaactcaa ctgggaggtc ttacatagtg aatcggtgat 1149781 aaaacagcag cagtattgcg tacatgttaa tatccccgac aaaatatgtt tttttcaaca 1149841 gattcgttcg acaaattttg caaattgtta atcgataact tttcattccc gatattaaaa 1149901 atgggagtga attgtaaaat gaaaaaacag aaaaataata aaaagaagaa tattgaaaag 1149961 cgaaatattg aaaagcgaaa tattgaagag aagaataatg aggacttaga agaactggaa 1150021 aatgcgattt atacttatca caaaaaggag ctacttgctt tctttcttga aaaaactcga 1150081 attggtcatg ataaggaaga atacaaaagg ttccaatctc ttctttataa gttggatatt 1150141 gaatgtttag aatttgctat atcgagattt tctcatatag atattatcca tgatcattca 1150201 aaatatgttc cagcctttat ccctttattt gcagcatatc tcaccatgtt ctttaatttt 1150261 tatgaaaaac attggggagc tttatctttt gctgctggta caattgctgc tattgtttgg 1150321 ataattgcag tagaaagaaa acatagaaat caagcaattt ctattatgaa aatatttgaa 1150381 caagtcaaag agagaaaagt gaaagacaga tctaaagact gaaaggagaa aatatgaata 1150441 aggataaatt aaggtatgca atcttaaaag aaatttttga aggtaatacc cctttgtcag 1150501 aaaacgatat tggagttact gaagatcaat ttgatgatgc tgtgaacttt ttaaaacgcg 1150561 aagggtatat cattggggtc cattattcag atgatagacc tcatttatac aaattaggac 1150621 ctgaactgac agagaaaggt gaaaactact tgaaagagaa tggaacatgg tctaaggcct 1150681 ataagaccat taaagagatt aaagattgga ttaaataata agagcatcct gcggggtgct 1150741 ttttttgttc cctgtaaact gcttccggta agtctcagga tagacaattg gcggttaacg 1150801 gcttgagcac ggtggtggtt tagagggaat atcttttcca aaacaacacg aatcagaagg 1150861 gggcggcggt gaatgtagat ggccgaaaag cacattcagg cgtataagga ttacgtcaaa 1150921 ggcatgaaat acaaggacct tgccgagaaa tacggggtgt cagtgaacac cattaaatcg 1150981 tggaagcagc ggcatggttg ggaaaggaaa aagggtgcac ccattgaaaa aagtgtgcac 1151041 acaaaaaaag gcgggcaacc gggcaacaaa aatgcattag ggaacaatgg cggcgcacca 1151101 cagaagaatc aaaatgctgt gactcacggc tttttctcta aattcttgcc agaagagacg 1151161 cttgaaatca tggaagagat tcaggagcgt tcgccagctg atatgatatg ggatcagata 1151221 cagattcaat atgcggccat tcttcgggcg caaaagatca tgttcgtttc tgataaggaa 1151281 gaaatgatca aagagctgaa aaagaaaagg tccctcatat ctgaggtcag cgaaattgaa 1151341 gatgggcttg tcattagttt tagtacgtgg tttcgctaca gactttacag tgaaacaaac 1151401 acctaacaca tttcacattg cttcagattg ccttcaaact tgataatata acttctaaac 1151461 cttcctataa aatgaaggtt ttttatttga tttcaatttt taaatccttt acatacagcg 1151521 attgattaac tcgagcaatc aatgtcgcag ttatatttat ttttcaagaa aatgttataa 1151581 tgaaaagcca taaaatgatg ggagggggaa tttcgatgca ttacataacg gcatgtttaa 1151641 aaatcatcag tgataaagac cttaatgaga taatgaagga attcaaaaaa cttgaggaag 1151701 aaacgaacaa agaagagggt tgtattacat tccatgctta tccgcttgag ccatcagaac 1151761 gtaaaataat gctttgggag atttgggaaa acgaagaagc tgtgaaaatc catttcacaa 1151821 aaaaacacac aatagacgtt caaaaacaag aattaacgga agtagaatgg ttaatgaaaa 1151881 gcaatgtgaa tgattgaaag gctctttaaa aagagacatt caatgactta gtatcagcca 1151941 cttgtgacta agtagtaaat tgttgtccaa ctcttatttt ttctatttaa tattttttga 1152001 gacgaaaatg tttttttaag ctgattttaa aatgtattca aagtcagctc tgtttgattt 1152061 aatggattat attatttgga tagcttgtta ccatcataat ggagatactc cttataaatt 1152121 ggaggttaaa ataatgagtc attctcaaga aaaaattgca ctaattacag gagcaagcag 1152181 tcaaggggat attggtacgg ctatttgtcg taagttagcc tcacagggta tacatatctt 1152241 ctttactcac tggaattctg atacggcctg gatagaagaa tttcaacaag aaattttacg 1152301 tatgggtgtc cgctgtgagg caatgaaaat tgatttatca gatgcacatg ctgcattcac 1152361 aatacatgaa aaaatttcag ataaattagg atatccttcc atccttatta ataatgcagc 1152421 tcattccgca agtgataatt atgtatcgtt agatgctaaa tcacttgatg agcattatgc 1152481 ggttaatatg agatcgaatt ttcttctttg tgttgaattc gcccgtcggt ttaaaaaatc 1152541 taatttaata tcaggaagaa tcatcaatat gacatcaggg caggatttag gtcctttgcc 1152601 tggggagtta gcgtatgcag caactaaagg agctatttct gcatttacta ggtcgttatc 1152661 acaagaactt gcaccattgg gcatcactgt taacgccgta aacccaggtc caacagattc 1152721 tacatggatg acagatgaaa taagaaattt tctttcacct aaatttccaa tggggcgtat 1152781 tggcacacca gatgatgcag cacgaatgat tgcctttctt gcaagtgatg aggctgaatg 1152841 gataactgga caaattattc attcagaagg tggatttatt cggggctaag ctaatgaaac 1152901 acggtataca ccaatgtatg atgtattccc aaaactaaat ctaaacttga agcgaaaata 1152961 aggtcccttc tctttttaga gggggacctt attttattca tgcatgtttt gcatccagaa 1153021 aatctggcgg ataaagatta ataaaccgtt acatatactt ttccgaatac tgcagtacct 1153081 ttaaacaaag taatcgtggc tttccctttt gatttagccg tcactaaacc attttgatcg 1153141 acttcagcaa ctttttggtt atcagtccaa taacgagtag ctgaattatt tttaacagaa 1153201 taggtttctc caacttttag aggtaaatta tagtcttgaa tcttgataac atgtgtaggt 1153261 gaaatagaaa tgttctttac ttcagtaggt gtggagttta tttcatgagc tgaagctacc 1153321 ccgctgaccg acagagctaa cgcagaaatc gataaagcag aaacaaccgt ttttttgaaa 1153381 ttcattttga aacactcctt taaagttttt tgtcttgcac tataacaatt caataaaagt 1153441 aattattttc cttgtaaata aatgttaata atatgtgaac gatcaattga tttgagctaa 1153501 gaatattgtg tgccctgcac agagtttgta tttatgatgg aaaattgctg agagagaatg 1153561 gccatcctta aaatgttaat agcacacatt tgatgggtat tagtttgttg agcgtgtgga 1153621 aattttgtta cctgcacttt atccccgaag ataccaaatc acttttcttc atcatgttct 1153681 tactttcgta ctcatacatt agaaaatctt cgttctaaat aggtgaagaa ttggagtatt 1153741 tttatgaatt tctgctgaat atacattaca tagcaaactc aaagagtata aaaatcgctt 1153801 ttttccggaa gcttcggtaa aaaacgaaac ttttgtctct atgattttgt tttataatgt 1153861 aaacggtttc ttatatagta tacttatact atcaatttgc tcaagtagat actgacagga 1153921 aggatagaaa aacagatgga atacataaat acaagacaaa aagagatttt gtatctgttg 1153981 ttatctgaac ctgatgacta tttagttgtg caagatttcg cagatagggt acagtgttct 1154041 gaaaaaacaa tccggaatga tttgaaagtg atcgaggatt atctcaatga gcattctcat 1154101 gcacagctta ttcgaaaacc agggttgggc gtttatttac atatagaaga acaggaaagg 1154161 acctggctaa gccaacaatt acatactgaa catttttctt ctaggcagcg gagcgataag 1154221 gaaagaatgc tgcacattgc ttatgactta ttaatgaatc cgaagcctgt ttccgcaaaa 1154281 gacattgccg ctcggcattt tgtcaatcga tcttccatta aaaaggattt atacgcagta 1154341 gaagagtggc tgaagcgttt tgatctcaca ctggtttcta ggcagcggct tggattaaag 1154401 gttgaaggga acgaaagaaa taaaagaaag gcattggcaa gaatatctga tttgattcac 1154461 aatacagcgt ttaccagcca atttattaaa agtaagtttt tacattatga agtagacttt 1154521 gtgacgaaag aaatcaaatc actacaaaaa aagcattccc tctatttcac agacgaaacg 1154581 tttgaaagtt tgttgctgca tacattgtta atggtccgcc gcatcaaaat gaagcagccg 1154641 atttcattgt ccccaaaaga aatggcggca gtaaaaaaga agaaagaata tcaatggaca 1154701 tttgcttgtt tacagcggct tgaaccggtt tttgcaattc gcttccctga agaagaagcc 1154761 gtgtacttaa cattacatat attgggcggt aaggttcgtt atccattgca gacagaagag 1154821 aaccttgaaa atgctgtgct tcctaaggtt gtagggcatt taatcaatcg tgtttcagag 1154881 ctgaaaatga tggattttca caaggatcag gatttgatca atggtttgaa cattcatctc 1154941 aatactgtgc tacaacggct gagctacgat ctttctgtag caaatcctat gctcaatgac 1155001 atcaaaaaga tgtaccctta tttgttccac ctcatcattg atgttttgga agacatcaat 1155061 caaacttttg atcttcatat tcctgaggaa gaggcagcat atttgacatt gcattttcag 1155121 gcagcgatcg aacggatgca gggcagcagc gagacacata aaaaggcggt tatcgtctgc 1155181 cacatgggga ttgggatgtc acaattgctg cggacaaaaa ttgaacggaa atatcaccaa 1155241 atcgctgtaa tggcttgtat tgcaaaggcc gatttaaagg attatatcaa aaagcatgag 1155301 gatattgatc ttgtcatatc caccattgcg ctggagaata taacggttcc ccatattgtt 1155361 gtgtctccgc ttttagagcc tggcgaagag aagaaattaa gtgcgtttat acgtcagctg 1155421 ggcgaatcac accgccaaaa acaaaaaacg tttcagatgc tgaacaatac gactcctttt 1155481 ttggtttttt tgcagcagga ggcggagcat cgctacaagt taatcgaaca gctggcgaca 1155541 gctttgtttg agaaaggcta tgttgataag gactatgcgg ttcatgcggt gatgagggaa 1155601 aaaatgtcgg ctacaaatat tgggtcaggc attgccattc ctcatgcaaa cgctaaattt 1155661 attaaacaat cagcaatcgc gattgccaca ttaaaggagc cgcttgaatg gggaaatgaa 1155721 aaagtttcgc tcgtttttat gctggctgtc aaacacgagg atcaaactat gacaaagcag 1155781 ctgtttagcg agctttcata tcttagcgag cagccggcct tcgtccagaa gctgacgaaa 1155841 gaaaccaatg tcatgacatt tttatctcat ttggattatt aaaagcaggg attattcctt 1155901 gctttttttg ttcatggcag ggcttgagaa ataaatttgc gagtgaagac gcctattctc 1155961 cagcaatgat ctaaataaaa taagagttta atagttggag aagaaatgtt acactctttt 1156021 ctgtatatgg taaagaatga aaaaacacga ttcggttggt agtccggatg catgattgag 1156081 aatgtcagta accttcccct cctcgggatg tccatcattc tttaatatct tttatgagga 1156141 gggaatcgtt atgaaattaa cgatttacta cgatggtcag ttttgggtag gcgttgttga 1156201 agttgtggac aatggaaagc taagagcctt tcgtcatctt tttggcaaag agccgaggga 1156261 ttctgaagta ttagagtttg ttcataacca acttttgaat atgatggccc aagctgagca 1156321 ggaaggagtg cgtttacaag gcaggcgtca aaaaaagatc aatccaaaaa gattgcagcg 1156381 ccaggtttca aaagagttga aaaacgccgg agtaacttct aaagctcaag aggcgataaa 1156441 gctagagctt gaagcaagaa agcaaaagaa aaaacaaata atgaaagaac aacgagaaca 1156501 tgtaaaagag caaaggtata tgctcaaaaa gcaaaaagcg aaaaagaagc acagaggtaa 1156561 ataatccaaa caaaagcagg cgcagtgcct gcttttgtaa ttaaggactc tactttgtaa 1156621 catatatcca atgtttatac tccgctgatt tatgattcaa tataaaccct aacttctcca 1156681 aggttttttg tgagcctaga ttatcatgtt cgcatcttgc ggtgatccgg gatactgttt 1156741 ctcggcttaa tgcccagttt attagttttt gggcggcttc cacacaataa cctttgcggc 1156801 gatgactttt atttgttgca aaaccgattt caatcatgcc attttcgtct gggtcaccta 1156861 aaaatccagt tcccccaaca atttcataat tgtccttctt tacaataatc catgaatcaa 1156921 atccttttgt tccattgttt ttgactaaaa tctcgcggaa ataaggtatc gcttcaaaaa 1156981 aatcagaatt tggccattca ccatttgttt catagcctaa ttctttgata gcctgatgat 1157041 cttgtttaga cgcggcgtca agaaggggaa tatcaatcgt ttgtaatcgt aatcgattcg 1157101 tttcaaggag aaccatatat ttaatcctct tttcttttta ctgggaataa tgataacata 1157161 taacaatttt ctctggtacc ttggcagtag agaaagatga aaaaattgag ggggattgaa 1157221 agagtgacag gtgagagttt gcccagacca aaaacgggta ggaaaatgct gatgttaatg 1157281 tgtccctacc cgtttttctg ttcctgaatg cagggtttct gataacatgt tgtgctacct 1157341 tttcgcaatc aaataaagcg atatggctct ttgggtttgc acaggattat gaatgataat 1157401 gacccattgg tttcttcgtc ttggaaagct tgctaccgca tacaatggag cagtatcgcg 1157461 cggagtgaac ccaccattta tcacgttgat atctcttcct tcaagatgac aaactaagta 1157521 ttcacctgga ttgatgacct gttggttcgt ccatgcgtaa gaataaaagc cgtctccaag 1157581 atcttcggtg gaagatgggg ggacaaagcc atctacagtc aatgtgattt ctcttcttcg 1157641 ctgtctttct gaaaagtctg gacttctttg agggttatga gtatgtgaaa agtaaggaat 1157701 taacgcaggg ccataaaagt aatgatacaa agcaaccact cctttatttt ccattcatac 1157761 aaattgtatg tgggagttat ttgttcattc ctgttttgtt ccatgtagac taataatggg 1157821 ctataggcgt ccaaggaaat caatttgtcc ttccgttgat tcaatgctag taaccttgaa 1157881 aatgcaggtt aggatgatag aatttacata ttactgcaag aagttagaca tacatcattt 1157941 tgatagtggg tgaaaacaat ggcgaaaaaa atggcaaaaa caaatgcggt tcgtctgata 1158001 gaacagcaga acatctctta tgaggtatta gggtataaaa cagacggcca gccggtagat 1158061 ggcatctctg ttgcggaaaa aatcggttat tctttgaaat atgtatataa aacgttggtt 1158121 gcagcagcag gaacaaatca ttattatgtc tttgttgtac ccgttgcaga agagttagat 1158181 gtaaaaaagg cagcaaaggt gacaggggaa aagaaaatag aaatgattgc aatgaaggag 1158241 ctgttagcgg taactggcta tcttcgcggc ggctgctcgc caattggcat gaaaaaattg 1158301 ttcccgacct atattgatgc atctgcagaa acgcttgatt ttattattgt cagtgcaggg 1158361 aaaatcggta tgcagctaaa gttggcgcca caagatttag ccagatcatg tgatgccgca 1158421 tttgcagaaa ttgtatagat gcagatatag gggaacgaaa aagcttagtc atatcgatta 1158481 agctttttcc gcatcccttt caaatatgat ttcaaaataa gcagctgccc catacccatc 1158541 tatactggga gcgaaaatct gaacgaatct ccagcctctt ttcgcataat catggatgat 1158601 ttgctggtag tcttctttag gccttcttct catcgtactc agctcaactc ttacgaattc 1158661 atattctttc atcgtttgat ccctcctatt aaggtatacg taaaatggag cgagaagttc 1158721 cgaaaaccta ggttaaggtc ggaaagtata tttcactcac taaacaaatc catttatgcc 1158781 tgatgcctgc atgcatctgg gaagagttaa ggggctataa aaacgaattt taccgggtca 1158841 gcagtccaaa tgaatctctt gcttattgca tttgactgag tatataagta aaaaaagagc 1158901 ggccagaaca tataagaagg agatgatcat taacgcactc ataacagggt agtgtttagc 1158961 ggagtagatg aaaaaatcaa gctgtgaaat ttgtttgggg ctgctgacgg catcaattcc 1159021 attaagcagt tttgagagtt tagcagtata gttccaatca aatcgatctg aaacaagctc 1159081 gcttccttga taccaattaa cagcagctaa aaacagaaat accataatag aaaatccaag 1159141 ctgaacaact aaaaatattc ccttcacttt tgtatgacct ccaaatctat gaatatggga 1159201 aaatcaaaca atatattacc accgtatggg ttattcttgc aatttcactt ccatacaact 1159261 caaacgcaag tctatttttt tgtttgtttt tggcttataa tacctgatga tggaaaaaga 1159321 gtgcgggttt atagattaga gaaacaaatg tatttcttag cattttttat ttgtggagag 1159381 agtatagaag cattcgatta gatctgcttt ttcacagaaa cggttttcat ctgtttgcct 1159441 gagctttaca attggctggc aaaaaaacaa tgatttcttt caatcaaaac atgcaacgat 1159501 gcgacacatt ttatatcttg atgacttatt tcattgcctt taagtcatcc tatcgagaaa 1159561 gcgatggtat tttatgaaca aagaaaccct aaaaaacata ctcatgattt tttcaatatg 1159621 cgcaacactc cgagaaaccg atggtatgcg catagctgat agctggattt tgagtgagat 1159681 tatacgattt ttgatttgca tggttgtgtt ttttgccatg acatttctat tagatgctgt 1159741 ttttccaaac aaaaaagagt cacattaatg tgtggctctt tttgcatcat ctgatcagaa 1159801 acatcataaa tgaatcgatc atcatgatga agaacagcaa gcaaaaataa ataagcgagt 1159861 agacaaacat atcctttgcc cacttcacgt catcgtctgt tttgaatcct ttgatgcttt 1159921 ttttgatcca tatgcctccg agaaccaagg cggctaagaa ataaaatggg cttatatggc 1159981 cggtgccgag agagaaagga aataatagcg tgaccggcac caggacggca atatattgca 1160041 tcatttttat ttttgttaca tgattgcctt tgactactgg caagagcgga acgccagcag 1160101 cgcgatattc ctctttgcgt cttatcccaa tcgcccaaaa atgcggcggc tgccacagaa 1160161 acataatcgt gtacaacagc actgctgtca tactgaagtc accggttacg gcacaatacc 1160221 ccatcaatgg cggcgcagct cctgggaagc tcccgacaaa tgtgctccac acagacgttc 1160281 gtttcaccca taccgtatag atgatcgcat aaaaaataaa ggcggccagt ccgagaaagg 1160341 ccgttaatgg attgagggaa taaagcatgg caagacctgc gattcctaaa acagagccat 1160401 atgttaagat catggctggc ggcattttcc ctgtgaccga ggccctgctg cgagttcgtg 1160461 ccatttttgc gtccatatgc cgatcaaaat agttgttata gacagtgccg gaagccatca 1160521 caaacgcggt tcccaacatt gctgttacca ttgtcatcaa aaaagccaag ccggttaacg 1160581 ttttttctgc gcttgcaaac gcgatccaaa acccgccgaa ggctgctatc gagtttgata 1160641 tgataatgcc cggctttgca agtttgataa aatcgtaaat ggttacccgg ttcgaagctt 1160701 ttatgtattt tgtttcagat atggctgcag aatctcttgt attctccaaa aatagacgcc 1160761 tcccccaaaa ctgcatgctt ttgttatcgt aacaagaggg ggacagaatc acaattattt 1160821 cccatatttg tcatgatatt gtcattttta aaacaaaaaa atggggagct ggactgcccc 1160881 cattttgata tgtggcgact agtaaccgta acctccccca tatcctccgc cataacctcc 1160941 gccgtaaccg taccaagggt agtaaggcgg tcgcgggcgc gggtagtaat aaggcgggcg 1161001 cggataaaac gggtagaacg gataatacgg tcttggataa taataaggcg gataaaatgg 1161061 cggtctcgga cgcggataat aataaggctg tctttcatca taaggggtaa tttgttcaaa 1161121 tgactgttca ttcaaagggt aatccaagag gaaaacctcc ctagcttttt ttattccttt 1161181 taccatattc ctgatgctta agttgggtgt atgtacattc atgaaattcg gtttttttta 1161241 tgatgaaatt ccttaaaaag gattgacatg aacttctaaa tctcatagta ttacaaatgt 1161301 gaaataaatg ttactacaat gttacaaaaa catttctaaa tagatacagt tccaactgat 1161361 gaagagtaaa tcgaaatggc tacgaaagaa ggagtttttg ttgttggcaa aaagaatcaa 1161421 atggtttcat gtattaatag cagttgtatg tgtggtgggc cttatcggct ttttccataa 1161481 tcattcattg aaaaaagaaa cggtcatgaa taaagtaaga actgattctc aatatgggaa 1161541 tgttgagatc gcaacgcttg tgaatgacgg gaaaactttt aattacgcgg taaactatcc 1161601 tgttttcaaa aatgaaaaaa tggattcggc attaaaaaga ttcgcagaaa aagaggttcg 1161661 tcaatttcaa aaggaaacaa aggacgttga ccaagagcat acgacaaaac gcaacgaatt 1161721 aaatgttgat tataaaattg tccattatgc caaacagaca gtggcgattg tatttaatga 1161781 atataaatac atcggcgggg cacacgggca aaccgtgaaa aaaacgttta actatgattt 1161841 tagtaaacaa gcgtttcttt ccattgatga tattttcaaa gaggacgctg actacttaca 1161901 taagctttcg ttaatcgctt atcacgagct gaaaaagaat aaggacattg ccgcggacga 1161961 tgcactgtta aaggaaggga cggctccgaa aaaagaaaat ttcagccgct ttgccatcaa 1162021 ggaggattat atcgaacttt actttgacac atatcaggtt gcagcaggct atcttggaga 1162081 gcaatcgatt gccattaaga aaagtctttt gaaagacatt ctgaaagaac aatatattga 1162141 taaagcaaaa aataaaaata aaatcaaaga acaaaagccg aagcatgaag tgatttcttt 1162201 acccaaagag gaaacagttg atccaaatca aaaagtcatt gcgcttactt tcgacgacgg 1162261 cccgaatcct gcgacaacaa atcagattct agactccttg aagaaatata agggtcatgc 1162321 cacgtttttt gttttgggga gcagagttca atattatccg gaaacgctaa taagaatgct 1162381 gaaagaagga aatgaggttg ggaaccattc atggagccat ccgcttctca caaggctttc 1162441 agtgaaagaa gcgttaaagc agatcaatga tacgcaagac atcattgaaa aaataagcgg 1162501 atatcgtccg acgcttgtaa gacccccata cggcggcatt aatgatgaac tgcggagtca 1162561 aatgaaaatg gatgttgcgt tatgggatgt tgacccggaa gattggaaag accgtaacaa 1162621 aaaaacaatt gttgaccgtg tcatgaatca ggcgggagat ggaagaacca ttttgattca 1162681 cgatatttac cgcacctctg ctgatgcggc cgatgaaatt ataaaaaagc tcaccgatca 1162741 aggctatcaa ttggtgacag tttctcagct tgaagaggtt aaaaaacaaa gagaagcgaa 1162801 ataaattaga aaaggctgtc cgtacggaca gccttttttc tatttaataa gagcctgtgg 1162861 tggcccaaac atttaagttt ggtcctgaat acttgccgaa agcgtaagaa gtccttggat 1162921 ctaaatcata taccatcggt gtatagcaag acttttggcc ggccaccgct tttccattgc 1162981 cgcctgcaga atcacaatta tatctttttc cgtctgtgtt ccgggtaatc tccgcatttg 1163041 cttcatagcc agacgtcaat gtattattca tcgtgatttt tgcccaagcc gttttacatg 1163101 tactgctgaa tttaagctcg actactccga tgacttgatt gctggcattc actaagtttg 1163161 aggatttttt tgtagagccg ctggacgcac aatcattgta ataagggctt tttccatcgt 1163221 aggcatgggt ttccgccttg gcgggtgcac ctttgacggc aaaaacaaat actactgcga 1163281 ataacaccaa tgaagccttc ataaacagtc ttttcaattt atgacctcct taatatggca 1163341 aacaataaat catatggagg aacaatcaaa acatgcatgc ttttttgtga acaataaagg 1163401 cggccgggag gatggagttc ttggccgcct ctggtatgag gttatgcttt tacatcaatg 1163461 gtttgtccga gagttggatg ttgaatcatc tttaaggttt gatcggcatt ttgctgggcg 1163521 gtgtccagcc tttttttcgt taaagcaata tttacattct gggcaaggga tgcttgatgc 1163581 atcgcaaccg ataaagcagg aatatccatg gttccacctc ctatgcctta cctatcggcg 1163641 ggtttgtatg attttacagt gaaaaatggc ttaatttctc ttgttgaccc ttacgctgcg 1163701 gcatatcgta tgtttttgac aaggagggaa tcaggatgaa tctagtaatg gaaaagacct 1163761 ttgagcaata cgaaaagctg ttttcaatgg aagaacagaa aagagaagat gtatttcggt 1163821 atacgatgat gaggccgttt gaaaagatgt ggaccgccat ccaagttccg ctgaaagcga 1163881 aggagccaaa cggctatgat gtgatcatgg ctgcgaaaat gctgggctat ttggatgtcc 1163941 gtgatgctga aagcggccag aaagcactac aaatactgaa agaatcacat gtttcagaga 1164001 cagctgaatc tgcacttcgg caatgcatat tttttgctga gcgcgaacag ctgcgggtga 1164061 atgcaaagga gatcaaattc ggcctttata tcgctgatcc aaataagctt cagctgcaaa 1164121 aaggctactg cgggtttggc gggataccgg gctttattca tgtatggatt aatccgaaca 1164181 gttataacct gccaaggatt ccttccatta ttgctcatga gtttcatcat aatgtgcggt 1164241 tttcgtatat agattttcat catggctctg taagtgtcgg ggattatctt gtgattgaag 1164301 gattggcgga atcattcgcc agagagctgt ttggtacgga acgattgggc ccttgggtaa 1164361 ctcgttttga tcatgaagac ttgcaatatt ccattgatgt gattaatgag gtgctggatg 1164421 tgaaaggatt ttcggaagtc agccgttata tgtttggtga tccaattgct aacgaccaag 1164481 gctttaagcc tgcaggttta tcggcttttg cgggttatgc agttggctat catgccgttc 1164541 agtcatttat gaatcaacat catatcacga taagcgaggc cacacgtttg gatgcgaaga 1164601 ccattatttc tcaatgcggt ctgttttcta catgaaaaaa gcgtcacata cagcggcgct 1164661 ttttgattcc caaaaccagc agttctatgg cggcacaggc ggcaattccg attgtatatg 1164721 cttcgatatc gctccataaa aaaccgtacc ctagtacaag cccgccaaga gaagtatctc 1164781 taatctggtc gatccattcg gcatgataga gctggctgaa ttcaatgaca aaacagaaag 1164841 aaagactgat aatgcccgtt atcattgtct tcagcttccg aaatagaaat ccgcatcccg 1164901 tgaagatcat ggcggcccac aacgagtctc ccagataagt attgagggta tcaggaagaa 1164961 cactggagaa tgctctggat ccaagcccca gcccaatgat cagtatggtg aaaactgcat 1165021 atatccaacg atttcgcttc attgcgaatt gataccccgt ctctgcttca tctccctgta 1165081 ttgtaaggaa tatagctttt atttgtccac taaaaaagcg gctgaatagc cgcgtagggt 1165141 gtttattttg cttttaggtt tacatggtcg gctgtctgat ccgtgcctat tacaaaatgg 1165201 agttcatagc ggcctgtatc atatacataa tcgatttcat cggtaaacgg gacggttaac 1165261 acccgattta ctggtcctaa ttgcttctgc agcacttccg gcgtaactcc gcctaaattc 1165321 agctgccgtt ccacaccggt tccaaagtag cggatttctg aaattgtcat gtctttatga 1165381 taggaaaatc cgtagcccgg ctgtcccata ttccagtgat ataaatcaaa tcgattgtct 1165441 cccccgactg gtctttccgg ttccccaaac gcagcgtgga catccccttt tgtgcttttg 1165501 ttaatggtaa ggccttgcgc ctgctgaggc atttcccctt tataggcggt gttatagagg 1165561 tttttgacaa gctcagcggc tgattgattc gtgttttctg agagtgtgtt tgtttgagct 1165621 gcggcctttg ccggtgctga aaaggacgca gccccaaagc cggtaaaaca gcttgttact 1165681 gctgctgccg cggttatagc agacattgtc tttttcatgt taatccctcc taattgatct 1165741 accattccgt ttccccgtgt ttttgcaacg aaacatgtga gtgcgctttg tatgttttat 1165801 tgagttgttg taagggaact gaaataggta attcggtata taaagcaaga aaggggaatg 1165861 gagatggctg gcaagaaaac aatcacaata aacggcgttg aaatggaagc gtccgaggaa 1165921 cagacggtgc tgcagctttt gaataacagc tcgattgaag tgccgcaagt ttgctatcat 1165981 ccaagcttag ggccgattga gacatgtgat acgtgcatcg tcagcatcaa tggtgagctg 1166041 aagaggtcgt gctccgctga attaaaggat ggggatgtca ttgatacgct ctcacctgac 1166101 gtgaaaaaag cgcaggtcat cgggatggac aagattttat ataatcatga gctttattgt 1166161 acagtttgcg attacaacaa tgggggatgc gaaatacata atacggtgaa ggaaatgaaa 1166221 atcaatcacc aaagcattcc gtttgatcac aagccatacc ataaggatga atcccatccg 1166281 ttttatcggt atgatccaga tcaatgtata ttgtgcggac gctgtgttga ggcatgccaa 1166341 gacgttcagg taactgaaac gctgaccatt gactgggagc ggaaacgccc gcgcgtcatt 1166401 tgggataacg acgtgccgat caatgagtcg tcatgtgtgt catgcggcca ttgttcaacg 1166461 gtctgtccgt gcaacgcgat gatggaaaaa ggaatggaag gggaagccgg atatttaaca 1166521 ggcatcaata acgaaacgct gcgaccgatg atcgagatca cgaaaggcgt agagacaggc 1166581 tacggctcga ttctcgcgat ttctgatatg gaatcggcca tgcgtgatga acgaatcaaa 1166641 aaaacgaaaa ccgtctgcac gtattgcggc gtcggctgca gctttgatgt ctggacaaag 1166701 ggcagagaca ttctgaaagt agagccgcag gaggaagcgc ctgccaacgg catttctact 1166761 tgtgtgaaag gcaagttcgg ctgggatttc gttaacagcg aagaacgcct gacaaagccg 1166821 ctgatccgtg aaggcgatca tttccgtgaa gcagagtggg aggaggcgtt attgctgatc 1166881 gccagcaagt tcactgaatt aaaagaggcg tttggcccgg attctctcgc ttttattaca 1166941 tcttctaaat gtacaaatga agaatcctat cttatgcaaa agctggccag aggggtcatt 1167001 ggcacaaata atgtggacaa ctgctctcgc tattgccaat ctcctgcgac tgccggcctg 1167061 ttccggacag tcggctatgg cggtgattca ggatcaatta cagatatcgc gcaagcggac 1167121 cttgttttga ttatcggttc gaacacgtct gagtcgcatc cagtcttatc cactcggatt 1167181 aaacgggctc ataagctgag agggcagaaa gtgatcgtcg cggatatcag aaagcacgaa 1167241 atggcagagc gctcagattt atttgtccag ccgcgtgccg gatcggatat cgtctggctg 1167301 aatgcgatcg ccaaatattt aatagaaaac ggcaaggccg atgaacgatt tttgagagaa 1167361 agagtgaacg gacgggatga atatgtaaaa agcctcgcgc cgtacacact tgaatatgct 1167421 gaggagaaaa ccgggattga tcaagaaacc cttatccaaa tggcagagat gatcgggcaa 1167481 gctgacagtg tgtgcgcatt gtgggcgatg ggcgtgacac agcatattgg aggaagcgac 1167541 acgagcacgg cgatctctaa tctgctgctt gtgacaggaa actacggaaa accgggagca 1167601 ggttcttacc cattgcgcgg ccataacaac gtgcagggag caagtgactt tgggagtatg 1167661 cctgacagac taccgggcta tgaaaaagtg acggacgaac aagtccgcca aaaatacgag 1167721 cgtgtgtggg gtgtgccgct gccgaaggag ccgggtatga ccaaccacga aatgattgaa 1167781 aaaatccatt ccggacagtt gaaagcgatg tatgtaaaag gtgaagaaat gggccttgtc 1167841 gactccaata tcaatcatgt acacgctgca tatgaaaagc ttgatttctt tgtggtgcag 1167901 gacattttcc tttcacgtac agcggagttt gctgatgtgg ttcttcctgc gagcccgagc 1167961 cttgaaaaag aaggaacgtt tacaaacaca gaacgccgga ttcagcgttt gtatcaggta 1168021 tttgaaccgc tgggtgaatc aaagccggat tggcagatta ttatggaggt tgccaataag 1168081 cttggcgccg gctggctcta tgagcatcct gcagacatta tggaggaagc agccaagctg 1168141 tcgccgattt atgccggtgt cacctatgaa cgtcttgagg gctataattc cctgcaatgg 1168201 cctgtaaacg ctgatggaaa ggattcgcct ttactcttta cagagcgctt ccctttccca 1168261 gacggcaagg ccattctcta ccctgtccag tggacagagc ctaaggaatt cggtgaggaa 1168321 tatgatatcc atgtcaacaa tgggcggctc ttggagcact tccacgaagg gaacctgact 1168381 tacaaatcaa aagggatttc ggagaaaaca ccggaagtgt tcttagaaat ttctcctgag 1168441 cttgcggcag aacgagggat tcaggacgga accctcgtca gactcacatc gcctttcgga 1168501 aatgtcaaag tgaagtgcct gattactgat cgagtcaaag ggaaggaagt atatctgcca 1168561 atgaacgatt caggggaagc ggcgatcaac ctgttaacag gcagccatgc cgataaggat 1168621 accgatacgc ctgcttacaa agaaacatcg gccaagatgg aaattttgaa gcacgacgga 1168681 atcagcccgc tgcctaagat caaccaccgc aacggcaatc cgcagccgca aatcggtgtg 1168741 caggttcata agaaatgggc gcggaaggat tatattttcc ctggtgacgc tgtgaaaagg 1168801 gggatgggcc ataatggcta aagcgattaa acgaatccaa aaaatcgagg taacagaaga 1168861 ggatcagcga aagcgtgatt tgcgggaaat tgaagatgct ctaattgacc acaaagaagc 1168921 gattctcgaa acattgcata tgctgggcca tatgaacgag cgcggggtcc tgccgttgct 1168981 ccgcggcctt tttggtcaag gggataaagt tcttgatatc ctggtgaaaa aggcagatac 1169041 agaggaaaca gccaatacgc tgaaaaatct gcttcttctg tttggaacac tcggcatgct 1169101 ggacgtgaag cagctggagc ctctcatttt gaaagtgaat gcgggtgtgg caagcgctgt 1169161 agagcagaaa aacagtgaag aaaagacagg ttattttgat attatccgct cgctaaaaga 1169221 cccggaaatc aacaaatcaa ttacactgct cttttccttt ttaaaaggaa tgggacaaga 1169281 tacaaaggag ctggaacgca cgacgcagcc tccggaacac caaaaacatc atcaggaacc 1169341 ccgagagaaa agaggaatga ataagcgaga ttgacctccc acccgagcgg cttcagccag 1169401 ctcgggtttt ttgatgaaaa ggtctaatgg actagtaaaa aatattcaaa tactaggaag 1169461 aagtaagatt gtgatgaatg agatagaaat aatcgttact ttcttacctg ttaagaaaag 1169521 ggaaaatctg attataatag aaatcgatta ctttagatgg gggaacaatc atgaaaaaag 1169581 tcttattact attatttgtc ttgacgatcg ggttagcgct ttctgcgtgc agccaatcga 1169641 gcgatgcgtc agagaaggaa aaaccgaaag agaaaaaatc gcaagaagag cttgaaaagg 1169701 aacttgataa ggaattgaaa aaaggcggtg agccgaagac caaaaaagat gatcaaatac 1169761 ataaaatagg agaaacattt aaagcaggac atacgaattt tacagtgaat aaagttgata 1169821 gagtgcaaaa aggtgaatat atgaatgttg gcggagctgt aaatgaggag acaaaaacaa 1169881 taaaagatga tgaggaacgg cttattatag aagttacgat ggaaaatata ggggaagatt 1169941 caataagcta caattttatc gggtttgatt taagagataa gaatgatcaa tcagtgcggc 1170001 ctgttttttc tatagaagag aagggcagaa tccttatggg aggaacacta gtatcgggga 1170061 aaaaggttac aggtgtactc agttatgtca tccctaaagg agaacagaaa cattacacac 1170121 tggtatataa tccgttttta gctgatacaa atagcagtaa tacagaagag agagtaaagg 1170181 acgatattga ttacttggtg aagttagatt agatgctaat ttacagttgc acgtttttca 1170241 tctgtggaaa acgtgcattt tttatagcga aacttgactt gaaaggatga gtgataaaag 1170301 tgcaaaccaa atggctggaa cgggcacagc ggattcgggc gatcgcccaa gcggggcttg 1170361 ctttttccaa ggatgtgtac gacagggaga ggtacgaaga gctaatgaag cttagcgcgg 1170421 aaatgatggc ggattactcg gagaaggaca ttgaagttat cactgattta tggcaaggcg 1170481 agaagggcta tccaacaccg aaagcggatg ttcgcggcgc tgtattcaga gagaatcaga 1170541 ttttgcttgt ccgggagaag catgatgagc tgtggtcgct gccgggcgga ttttgcgaga 1170601 ttggtttatc gccggctgaa aacgttgtca aggaaatcaa agaagagtcg gggtacgata 1170661 cagagccgtc tcgattgctg gccgtgctag acagccataa acactctcat ccccctcagc 1170721 cttatcacta ttataaaatc ttcatcgcat gcagcatgac ggacgggcag ggggaaacag 1170781 ggatcgagac gaatcatgcc gctttttttc cggaagacag actcccgccg ctttctccta 1170841 aacgaaacac accctcacag cttagcatgc tgtttgactt tttgcgccat ccggacaaga 1170901 aaacgatatt tgactaaaaa agaaagagcc tgtgggctct ttctttttta taatgtaatg 1170961 tgtttttcgt tggcgagttt cagaagggtc aaaatagaat cggcttgttt atggccgagt 1171021 ttttgcttta atttgttttc ttcaactaat cggctgccat aaattttgac ggaggctttg 1171081 tcgacgacag tatgccagtt ttcctgtttt tttccctcaa caagcggttt ttcatgtctc 1171141 tcagaaaaag agaacacaaa gagtacgaat gcaagtgaaa gtaggattcc gacaacttgt 1171201 tttttgtaat cagtctgtgc tgccacgttg ttctctcctt caccttttac cttctattta 1171261 atcatagaac caaattattt tacataatgg gaaagtcatt tttggagtta gtgcatttgg 1171321 ttgaaaacag agacgttttt tgagcggagc ggtgcaattg aatccatatt ggatttgcgt 1171381 gcttatgcct aaggtcacgt tgtgagccaa aacagcagtg cagaatagaa aaaaattgaa 1171441 agattatggt aagatgaacg aaattcgagg gggaatatat gatgcctgca tcgaacatcg 1171501 tgatcgcctg cctgctgtta tcaatttaat tatttgtggt agtccctctc tttttcgaaa 1171561 gcgggaggtg aagtggaaca ttaattgctg aattctttca aggggagtga ccgtacatga 1171621 atgtgttaaa ccgccggcaa gccttgcagc gagcgctgct caatgggaaa aacaaacagg 1171681 atgcgtatca tccgtttcca tggtatgaat cgatgagaaa ggatgcgcct gtttcctttg 1171741 atgaagaaaa ccaagtgtgg agcgtttttc tttatgatga tgtcaaaaaa gttgttgggg 1171801 ataaagagtt gttttccagt tgcatgccgc agcagacaag ctctattgga aattccatca 1171861 ttaacatgga cccgccgaag catacaaaaa tccgttcagt cgtgaacaaa gcctttactc 1171921 cgcgcgtgat gaagcaatgg gaaccgagaa ttcaagaaat cacagatgaa ctgattcaaa 1171981 aatttcaggg gcgcagtgag tttgaccttg ttcacgattt ttcatacccg cttccggtta 1172041 ttgtgatatc tgagctgctg ggagtgcctt cagcgcatat ggaacagttt aaagcatggt 1172101 ctgatcttct ggtcagtaca ccgaaggata aaagtgaaga agctgaaaaa gcctttttgg 1172161 aagaacgaga taagtgtgag gaagaactgg ccgcgttttt tgccggcatc atagaagaaa 1172221 agcgaaacaa accggaacag gatattattt ctattttagt ggaagcggaa gaaacaggcg 1172281 agaagctgtc cggtgaagag ctgattccgt tttgcacgct gctgctggtg gccggaaatg 1172341 aaaccactac aaacctgatt tcaaatgcga tgtacagcat attagaaacg ccaggcgttt 1172401 acgaggaact gcgcagccat cctgaactga tgcctcaggc agtggaggaa gccttgcgtt 1172461 tcagagcgcc ggccccggtt ttgaggcgca ttgccaagcg ggatacggag atcggggggc 1172521 acctgattaa agaaggtgat atggttttgg cgtttgtggc atcggcaaat cgtgatgaag 1172581 caaagtttga cagaccgcac atgtttgata tccgccgcca tcccaatccg catattgcgt 1172641 ttggccacgg catccatttt tgccttgggg ccccgcttgc ccgtcttgaa gcaaatatcg 1172701 cgttaacgtc tttgatttct gcttttcctc atatggagtg cgtcagtatc actccgattg 1172761 aaaacagtgt gatatacgga ttaaagagct tccgtgtgaa aatgtaatag ataaggagac 1172821 tggagattca tgaaaaagta ccatatttcg atgatcaata tcccggcgta cggacatgtc 1172881 aatcctacgc ttgctttagt agagaagctt tgtgagaaag ggcaccgtgt cacgtacgcg 1172941 acgactgagg agtttgcgcc cgctgttcag caagccggtg gagaagcatt gatctatcat 1173001 acatccttga atattgatcc taagcaaatc agggagatga tggaaaagaa tgacgcgccc 1173061 ctcagccttt tgaaagaatc actcagcatt ctgccgcagc ttgaggagtt atataaggat 1173121 gatcagcctg atctgatcat ctatgacttt gttgcgctgg ctggtaaatt gtttgctgaa 1173181 aagcttaatg ttccggtcat taagctctgt tcgtcatatg cccaaaatga atcctttcag 1173241 ttaggaaatg aagacatgct gaaaaaaata agagaagcag aggctgaatt taaagcctac 1173301 ttggagcaag agaagttgcc ggctgtttca tttgaacagt tagctgtgcc ggaagcatta 1173361 aatattgtct ttatgccgaa gtcttttcag attcagcatg agacgttcga tgaccgtttc 1173421 tgttttgtcg gcccctctct cggagaacgg aaggaaaaag aaagcctgtt gattgacaag 1173481 gatgatcgcc cgcttatgct gatttctttg ggtacggcgt ttaacgcatg gccggaattt 1173541 tacaagatgt gcatcaaggc atttcgggat tcttcatggc aagtgatcat gtcggttggg 1173601 aaaacgattg atccagaaag cttggaggat attcctgcta actttaccat tcgccaaagt 1173661 gtgccgcagc ttgaggtgtt agagaaagct gatttgttca tctctcatgg cgggatgaac 1173721 agtacgatgg aagcgatgaa cgcaggtgtg ccgcttgtcg tcattccgca aatgtatgag 1173781 caggagctca ctgcaaatcg ggttgatgaa ttaggccttg gcgtttattt gccgaaagag 1173841 gaagtgactg tttccagcct gcaggaagcg gttcaggctg tatccagtga tcaagagctg 1173901 ctcagccgcg tcaagaatat gcaaaaggat gtaaaagaag ctggcggagc ggagcgtgcg 1173961 gcagctgaga ttgaagcgtt tatgaaaaaa tccgctgtcc cgcagtaaaa acataaaaac 1174021 cgaaatcaat ttgatttcgg ttttctgttt aaatattttt tttcatcccg catctccggc 1174081 attctctaag aaattttccg ccttttacag agcttttgaa cagtgtgtaa tcacagttgt 1174141 cgcagcgccc gctgcgggca tccggatatt cattgaattc gtaaacaatc gatgtatcgt 1174201 agccttttgt ttcatattct tcttttttgg tttccatgtc gatcctccgt tacaagacgt 1174261 gtctgctgtt tatcttacag caagcttccg gcgtattcaa tggattttag gaggttgggt 1174321 ttatcttgat ttctcccttg gtttgcgcca aaatagcttt attaagctta tatacataaa 1174381 aagcctatgc aaagaggaga ggaaacgggt atgggaaaag ggttacttgg aaaacgcgtg 1174441 gcaatcggtg gctcacgaaa aacggaagaa attagtacaa tcattgaaaa acagggcgga 1174501 atacctgtca tccggcctct ccaaggtaca gtttacttag cagagaagca ggtggagccg 1174561 gatttgcgga cgtttgcgga agaaaaagct gactgggtca ttttcacgac aggcatcggg 1174621 ttggagactc ttgtcgatat ggcagagaaa attggactga aagatgagtt tctgcaggcc 1174681 attcgccaag cgaaagcggc atgccgggga tacaaaacgc tgtctgcgct gaaaaagctt 1174741 ggaatcacac cggaagcttc ggatgaagac gggacaacaa gaggcttaat ccgttccttg 1174801 gagcctcacg acttttcagg aaaaacagtc atggtgcagc ttcatggcga aaaagcgccg 1174861 gctctcatgg catttcttga agaaaaaggc gcgtctgtcc tgccgattct gccttatcag 1174921 cacatcccgc cggaggagga aacggtggag cggttatgcc gagagctgat gaacgatgag 1174981 gtcgatgccg tttgttttac aacggccatt caggttcgtt ccctgtttga ttttgccaag 1175041 gggcgaggtt atatcaatga agtgaagaag gtattcgaag aacgcgccat cgcagctgct 1175101 gtcggaaaag tgactgctga agcactgcgg gaagagggca ttacgagact gcttgcgcca 1175161 gagattgagc ggatgggtgc gatgattgtt gagctggcca agtattatga agaaaaggaa 1175221 taacaagtac aaaaagccgc ttttccctcg gaaagcggct tttgtctgtc attcattttg 1175281 cttcagctgc tgatgaacgg tgaataatga tgggtatgtc agcacgctta agattacaca 1175341 agtcagcgcg gctgaggcca tcgttgtaaa cacgattaag agttgaaagc gtactgcctg 1175401 aatcgggtcc gcgccggcta gaatctggcc agtcatcatg ccgggaagct ggacaagacc 1175461 cagtgttttc tggctttcga gcgtcgggat catactcatt ttcatcgctg aggtaagaat 1175521 gcgctgtatg gattgcttcg gtgtgccgcc aagtgacaat attaattgaa tttcttcttt 1175581 gcgaacgccg acttctgagt taagccggtt tagaaacaaa cttgagagca ccatcgaatt 1175641 tccgatgacc atcccgctga tcggaatgac atatcgtgcc gtaagcggaa tgatatgaag 1175701 agacagcaga attccctgcg tcacaatttc tacgattgct aacgcggcaa acaccctcca 1175761 aaacgaaccg atagtatttt tctttcgctt gatgacattt tgcgccgcca ccgcgagcat 1175821 taacagcacc atcagcagga taaaaacagg gtggtctccg cgaaaaatca gcgacaaaac 1175881 ataaccgatg ataagcagct gcaccgcggc ccggatggtg gcgatgatca tgtctttttc 1175941 tacaccggct ttaaaggatt ttgataaaaa caaggcgatc aaaacaaaga tcatcgttaa 1176001 agagagagaa aggtaatcca ttaccgagtg cctcccttca aaaattcttt cgctgcttca 1176061 tgctgcggag cggagaaaaa tgtgtcggtt tcagcgattt caagcagccg gccatctgcc 1176121 ataaaccaaa tggtatcggc tattcgtttt gcctgctcca tattatgagt gacccacatg 1176181 actgtccatt ttttctcttg atgctgacgt ttgatcagtt cttcaatctc aagagcagag 1176241 accgggtcca aggccgatgt gatttcgtcc aacaatagaa tggaggaagg atttgagagc 1176301 gttctggcca gtgacagtct ttgccgctgc ccgcccgata agtctctggc gcttctgtct 1176361 aacaactctg gcggcagccc tgcaagcgaa gccagctttt caggagagta cagctgggat 1176421 tgatgcagcc tttgtacaag acttaaattg tcacgcactg tcccgtcgag cacgggagcc 1176481 gattgaaacg cgagggctgc cgttcgcctc agctcattga cattccattc tctgacttcc 1176541 tttccgtata tgttgacttc gccgctgtca ggcgttctca ttaaattaca catagaaagg 1176601 agggtgcttt tgcctgagcc ggaagggcct aaaacggcta cgattgcacc ctgttgaatg 1176661 tctccggtga catcctgcag cacatcatag gtttgtccat cttgtttata gctttttctg 1176721 actgatctga aggagatggc tggtatgttt tgtgtttgat cgtttgcttc cattacaata 1176781 atcacctttc aatataagta ggctgacatt atatttaact ataacgtgaa acagattcct 1176841 tttggtagca caaataaagg agaacaggct ttcacccatt ctcctgcaga tgctacgcag 1176901 tcagatttga ctgtgctttc tttttcggtt ttctcggctg tgaagcgaag gtatgtaaca 1176961 tcatccccgc tattataatg aacaaaccgg caaatgataa tagagatggg aaaacgcctg 1177021 acagcagaac aatttcacca agcagcgcga aaatcacttc accggattga gtggcttcaa 1177081 cagctgcgag tttttgcgga ttgtctctta ccatatcagt ggcccagaaa aataaaaccg 1177141 tcgcaatgat gcctgagctg acggcaacga taaaggattg aacggtttga cttgctgttg 1177201 gaaggccatc tgaccaccag ccgtaagctg ctaatataag ccagaatgga aggcttgcca 1177261 atgtcattcc aagcacgcgc tgaaatgtat caagccggcc tccgtattct tcgagcattc 1177321 ttcggtttcc taacggatag gcaaaagccg caatgacaac cggcagcaca ctgaaaagca 1177381 gcatcctccc agaaagcgat tctgcatgct gaagctgaat cagagccgct ccaatcagga 1177441 tgatcacaga agtgccaagt gaaaccaggg gaatcttttg gcgaatgagc tgcggaccgc 1177501 ccggcatatc ttgtttgaca taaaacaaag gagataagag caccccggct acaattgtaa 1177561 tttgccaggt tccagctatg agccaccccg gaccgtatgc agccgcaaat gtaatcggtg 1177621 cgtaaaaaag cacgaaaccg acgaagctcc atttgatcca ataaaacggc tttttcctca 1177681 tttctagtaa gagaggcgtg aatgtccctc tcatgatgac aatcaaacat aaaaatggca 1177741 ccataaaaat aaagcgcagc gaagagctcc aaagccagct gcctcctgat aactccatcg 1177801 ctctgtttaa tataaaggta acggcgaaaa agagtgaagc caatattccg ataacgatag 1177861 ctttcatgat atccctcatt ctggcattat ttttttatac tatactattc ggtatcatgc 1177921 agatcaatgg aatcatgaga aaaacatcat gtttggcgaa ccgctatatg tggaagacaa 1177981 aaaagggagg tgaaattgat ggaaagagag acacagacat acttctttcc ggatgacggc 1178041 aggattccga atcaccctga ttttccgctc gtggtgtatc aaaacgcgct taaggacacc 1178101 ggactggcag agcggatcgt cacccggcat ggctggtcaa acagctggtc agggagtgtt 1178161 tttccatacc atcattatca cagcaatacg catgaagtcc tgattgccct taggagagag 1178221 gctgtgattc agtttggggg agaaaaaggg gctgccatcc ctttcaaatc aggcgacgca 1178281 gtcgtgattc cagccggagt cggacataaa aagctcagct caagccccga ttttactgtc 1178341 cttggcgcct atcccggtgg cgttcagtac gatatgaaga cggggaagcc gaatgagcgg 1178401 gaggaagcgg tcaaacagat taagcaggcg gcgttgccgg cgaatgatcc gatcacagga 1178461 aaaagagagc ctctattgga aatatgggta aagtgaaggg gagaaattgc tggattgtca 1178521 ataactagtg ccgcagaaac gatatgacat gagctccata taaattaatt tcataatcga 1178581 agcaattcac gttcaaattt tgttcaaaaa gtgttatcat atagaaggta atcgaattgg 1178641 agttttttgt gtttgctatt ttcagagaga gtaaaggatt ttgacttatt caattgttta 1178701 tttttagata aaaataatac tgaatatggc aagatgaaaa actgggtagt aaacatttat 1178761 ttttgtaaat gattgtgcat gaattcacaa tccttattct tatgccttaa aagcgtgaga 1178821 cagggagagg cactaccctt tccaaaaaaa tcagcaaact gcttatagta aaggagaatt 1178881 ggatatgcca gaaacaatcg atcaaacaaa tgcgtctgtc agccaaagcc agcaagatct 1178941 tattgatcag ctattaaagc cagaagttca agaatcattg actgttttag ttgaccagct 1179001 tccgaagctg actgagttag tgaatatttt aacgaagtct tatgatttcg ctcagtctgt 1179061 agcgactgac gaagtgttaa agagcgacac agtcggtgcg atcactgaaa ttctcgagcc 1179121 tgtaaaagaa acagcgaaag aagtagctgc gactgcgatc gaagcaaaag accgcgcgga 1179181 agcaagcaac gaaacaattg gacttttcgg ccttcttcgc atgctgaaag atcctcaagc 1179241 tcaaaagctg ttccgttttg ctaacagcta ccttgaagtc atgaacgaac gcgaaaacca 1179301 aaaataatct cagattcaaa ttgatataaa ggacggagga tatacgatgt caaaacatat 1179361 tgtcattcta ggcgctggtt atggcggagt tctttctgct ctaacagttc gcaaacatta 1179421 cacaaaagaa caagcacgcg tgacagtggt aaacaaatac ccaactcacc aaatcattac 1179481 ggaattacac cgccttgctg caggcaacgt gtctgaaaaa gcggttgcaa tgccattaga 1179541 aaaacttttc aaaggcaaag acattgatct taaaattgcg gaagtaagct ctttctctgt 1179601 tgataaaaaa gaagttgcgc ttgctgacgg ttctacatta acttacgatg cgcttgttgt 1179661 aggtcttggt tctgtaacgg cttacttcgg catcccaggt cttgaagaaa acagcatggt 1179721 attgaaatct gctgccgatg cgaacaaagt cttccaacat gttgaagatc gtgtgcgcga 1179781 gtactctaaa acgaaaaacg aagcagatgc aacaatcctt atcggcggag gcggcttaac 1179841 aggtgttgag cttgttggtg agcttgctga catcatgccg aaccttgcga aaaaatacgg 1179901 cgtagaccat aaagaaatca aattgaaact tgttgaagca ggtccgaaga tccttcctgt 1179961 tcttccggat gatcttatcg agcgtgcgac tgcaagcctt gaaaaacgcg gcgttgagtt 1180021 cttaacaggt cttcctgtta caaatgtaga aggaaacgta atcgatctga aagacggatc 1180081 taaagttgtt gccaacacat ttgtttggac tggcggcgta caaggtaacc cattagtcgg 1180141 tgaatcaggc ctagaagtga accgcggacg cgcgactgta aatgacttcc tgcaatctac 1180201 atctcatgaa gatgtattcg ttgctggaga cagcgcagtt tacttcggtc cagacggccg 1180261 tccatacccg ccaactgcac aaatcgcatg gcaaatgggt gagctgatcg gttacaacct 1180321 attcgcttac ctagaaggca aaacgcttga aacattcaag ccagtaaact ctggtacact 1180381 tgcaagcctt ggacgcaaag acgcggttgc catcattggt gctaattcta caccgcttaa 1180441 aggtcttcct gcttccttga tgaaagaagc aagtaatgta cgatatttga cacatattaa 1180501 aggacttttc agcctggctt actaatcctt ttaatgaatc tggcattgcc aaaagcattc 1180561 ctttccgagt gctttctggc aatgtctttt tttatgttta tgacagcgtt aacatttcat 1180621 tttcaaaaaa gagattgatc ccaaaggaat ataaaggtaa aataaaaaca aatcaaaatg 1180681 ttaacgttaa cattttgaaa tagaatgaaa gacggtgagg acatggaacc cttcatgggc 1180741 aaaaactttt tattgaaaaa tgaaaccgct gtcagcctct atcacaatta tgcgaaagac 1180801 atgccaatta ttgattacca ctgccactta agtccgaaag aaatctatga aaataagaca 1180861 tttcaaaaca tcacggaagc ctggctgtat ggtgaccatt ataaatggcg catcatgaga 1180921 gccaatggaa ttgaggagac atacattacc ggagatgcgc ctgatgagga gaaatttatg 1180981 gcttgggcga aaaccgtgcc gatggcgatt ggcaacccgc tctacaactg gactcactta 1181041 gaattgcagc gtttttttgg catttacgag attttaaacg agaagtccgg gtcggctata 1181101 tggaaacaga caaataaact gctcaaaggg gaaggcttcg gggcaaggga tttaatcgtg 1181161 aaatcaaatg taaaggtcgt gtgcaccaca gatgaccctg ttgattctct tgaataccat 1181221 ttattgttaa aagaagacaa agactttcct gtcagtgtgc tgcctggatt tcggccggat 1181281 aaaggacttg agatcaatcg tgaaggcttt cctgagtggg tgcaggcgct tgaagatgcc 1181341 gctgccatat cgattacaac ctatgatgag tttttaaagg cgttggaaaa acgagtgcga 1181401 ttcttccact cagccggcgg cagagtttct gatcacgcga tagatacaat ggtatttgcc 1181461 gaaacaacaa aagaagaagc tggacggatt ttttctgaca gattacaagg aacagaggtt 1181521 tcttgtgaag atgagaagaa atttaagaca tatacgcttc agtttctttg cggtttgtat 1181581 gcggagctcg attgggcgat gcagtttcat atcaacgctt taagaaacac gaatacaaaa 1181641 atgatgaaaa ggctcggacc tgatacaggg tatgattcaa tgaacgatga agaaattgct 1181701 aagcctttat acaagctgct gaactcagtt gagatgaaga accagctgcc gaaaacgatt 1181761 ttatattcac tgaatccaaa tgataactat gtcatcgcca gcatgatcaa cagttttcag 1181821 gacggtatta ccccgggaaa aatacaattc ggcacagcct ggtggtttaa cgatactaaa 1181881 gacggaatgc tcgaccaaat gaaagcgtta tcaaatgttg gccttttcag ccgttttatc 1181941 ggcatgctca ccgattccag aagctttctt tcgtatacgc gccacgaata tttcaggcgg 1182001 atcgtctgca atttgattgg agaatgggtg gaaaacggcg aagtgccgcg cgatatggag 1182061 cttctgggaa gcatcgttca ggggatttgc tatgacaatg cgaaacacta ctttcaattt 1182121 caagaagaga aagcaaacgt gtaacaaagt gtccgctcag tatcgctgag cggatcacta 1182181 tccgaaaatt cttaagacac agaggtggaa catgcgaact gaactggcaa ataaggttgt 1182241 gtcggtcgaa acggaaaaaa ggctttcatt gaaagagaaa atgtcctatg gctttggtga 1182301 ttttggcaac ggttttatgt ttgatctcgg ccagatttat ttattgaagt atttcactga 1182361 tgtagcggga atccccgctg cgatggccgg cggcattttt ttagtcagta agctgtttgc 1182421 agcgataaca gatccaattg tcggctcatc aatcgattat cgcaaaaaca tcggcaaacg 1182481 ggggaaattc aggccttatc tattaatcgg cagcatcgtg cttgcggtgc ttactgttct 1182541 tatttttctg tctcccaatg tatcaacgac cggaaaactg atatatgcat atgcatccta 1182601 tatgatttgg ggcatcggct attcgtttgt gaatattccg tacggctcat taggggcagc 1182661 gatgactcaa aattctgagg accggacctc catttcgacg ttccgccaaa tcggatcact 1182721 tggcgccttg tttatcacaa gtgtggccgt gatgccgctg ctcgtcaagt ttgataatcc 1182781 gaaggtcggc tacccggtgg tcatgggctt gttcgccgcg ctcggtgtgt tttggtttta 1182841 tatttgctac cgcaactgca aagagcgcat tatcatatcg gaagcaccca aagaaaaatt 1182901 aacactctca tctgtcgtca aaacatttat tacaaataaa ccgctgttaa cccttgtcct 1182961 gatgacgatt ttttcaattt ccgcatacaa cattaaatcc gccatgctcg tctatttcgc 1183021 acaatataac ttgggcaatg ttgaattaat ggcttatatg aacttcatca ttattggttc 1183081 ttcctttttg ggcgtcgtat tccttccaaa gctcgtcaag atgtttggaa agaaacgaac 1183141 ggcaatgatc ggctttggca tcagtgtggc cgcggatctg atcaacttta tgcttccatc 1183201 taacgtttat gtgtttacaa ttctcgccag tatcgccttt atcggaatca gtatcccaaa 1183261 tggcatcacg tgggctcttg tctccgatat tatcgactat ggcgaatgga aatccggtga 1183321 acggaaggaa gcaacgacat attcactttt caatttctca agaaagcttg ctcaatcttt 1183381 gtctggcttt ctctcgggga tcggtttggg gattatcggc tatgtgccga atgcagtcca 1183441 gacagcacag gcgctgattg gcatcaaagc gctgcttctt ctgtatccgg ccattgcttt 1183501 ggcattagcg atgttcatta tcggctttct ttataaactc acagaccagc agcatgctca 1183561 gatcgttcag gatcttcatc aaaagagctg acaatataat ataaagaata tttaaaataa 1183621 tttgtaaata aaatgtgttt gtaggggttt cgcttggaga gtgcccaaaa aactgaaaag 1183681 gaaggaggca cttgcttgaa aacgataaca attgcagctg aagaagcaaa ggaactcgtt 1183741 tggcaaaagc tggacggtgc cggtttgaat gaacgagatg ctgaaaaagt ggcagatgtt 1183801 ctcgtgcacg ctgatttgcg caatgtacat tcgcatggcg tgctgcacac agaacactat 1183861 gtgaacaggc ttttagcggg agggatcaat cctggggcac agcctgtttt taaagagacg 1183921 gggcctgtga ccggggtgct tgacggagac gatggtttcg gtcatgtgaa ttgcgacatg 1183981 gcgatggacc atgcaattga catggcgaag aaaaaaggag tcggcatggt cacggccgta 1184041 aacagcagcc attgcggagc gctaagctat tttgtgcaaa aagcggctga cgaaaagctg 1184101 atcggaatgg caatgacgca tacagacagt atcgttgtcc catttggggg gaggactcct 1184161 attttaggga caaatccgat tgcttacgga gttccggcta agcataaaaa accgtttatc 1184221 ctagatatgg cgacatccaa agtggctttt gggaagattc tgcaggcccg tgaagagggc 1184281 aaagaaattc ctgaaggatg gggagtcgat gaaaacggag aagcagtaac tgatcctgac 1184341 aaggtcgtct cactttcaac attcgggggc ccgaaaggct atggactatc gattgtagtg 1184401 gatgtgtttt ccggattgct ggcgggcgcg gcttttggcc ctcatattgc caaaatgtac 1184461 aacggccttg atcaaaaaag aaagctgggg cattacgttt gcgcgatcaa tccatccttt 1184521 tttactgact gggatacgtt tttagagcag atggatgcca tgattgatga actgcagcaa 1184581 tcaccgccgg ctgttggatt cgaaagagtg tatgtgcccg gcgagatcga gcagctgcat 1184641 gaagaaagaa ataagaaaaa cggaatttct atcgcccgga gcgtgtatga attcttaaaa 1184701 agcaggtgag taaaatgaaa gcggttcaag tgcgaaaagc gtatgatctg gtgacagcgg 1184761 aggtgaagaa gccagttctt tcaaaggatg atgaagtgct cgtgaaagtc aagcgagtcg 1184821 gcatttgcgg ttcagacatg cacatttatc atggaacgaa tccgctcgct accctcccga 1184881 gagtcatcgg acacgaggta acgggacaag tggaggcagt tggtgcgaat gtacagagcc 1184941 taaaacccgg tgatcatgtg gtgattgagc cgatttctta ttgcggatcg tgctatgcct 1185001 gccgcaaagg gcggccgaat gtttgcgcca agctttctgt atttggcgta catgaggacg 1185061 gaggcatgcg ggaatatatt gtgcttccgg aaagacagct tcacgcggtc tcaaaggact 1185121 tgccttggga ggaagcagtc atggccgagc cttatacgat aggcgcccag gcagtgtgga 1185181 gaggccaggt ggaaaaaggt gataccgtcc tgatccaggg agcggggccc atcgggatct 1185241 gtgtgttaaa aatggcaaaa ctggcgggcg ctgctgtcat gatgactgac ttgaacaacg 1185301 agcggctggc atttgcgaaa gaaaacggcg ccgatgctgt tgtaaatgtc caagcagaac 1185361 atgttgccga gcgggtcctt gaatggactg ggaatgaagg agcaaacgtg gtcattgatg 1185421 ctgtttgcct gccggagact tttgcacttt caattgaggc tgtgtcaccg gcgggacatg 1185481 tggttgtgct tggatttgat gaaagagcgg ctcagatttc tcagctgcca attacaaaaa 1185541 aagaagtcac gataaccgga tcccgattgc agaccaatca gtttccaaaa gtggtagagc 1185601 ttttgaatgg aggccggtta atgcataacg ggctggtgac ccatacattt tcagttgatg 1185661 acgttcatca tgcatttcag tttattaagg agcatccaga tcaggtgcgg aaagccgtca 1185721 tcacgtttga ttaaatgact gaatccggag gtgcgagcat gaatatgaca ttccgatggt 1185781 atggacgagg caacgataca gtcacacttg aatacgtgaa gcaaattccc ggtgtcaaag 1185841 gcatcgtttg ggctctccat caaaagcccg tcggcgacgt gtgggaaaaa gaagaaatca 1185901 gagccgaaac tgaatatatt caatcctatg gttttcatgc tgaagttgta gaaagcgtga 1185961 atgttcacga agcgattaaa cttgggaacg aagaacgcgg ccggtatatt gaaaactaca 1186021 agcaaacgat ccgcaacctt gccggatttg gcgtgaaagt gatctgctat aattttatgc 1186081 cggtttttga ttggacacgc acggacatgt tccggccgct agaagatgga tcgaccgctc 1186141 tgttttttga aaaggccaag gtggaaagcc ttgatcctca agagctgatt cggacggtgg 1186201 aggaagcatc cgacatgaca ctgccggggt gggagcccga aaaattggct cggatcaaag 1186261 agctttttgc tgcctacaga acggtcgatg aagaaaagct atgggacaat ttatcattct 1186321 ttttgcagga aattcttcct gttgctgagg cctatggtgt tcaaatggcc attcatccgg 1186381 atgacccgcc gtggccgatt ttcggactgc cgcgcattat cacaggagag gcaagctata 1186441 agaaactgcg ggcgatatca gattcaccgt ctaattgtat caccctttgt acaggttcaa 1186501 tgggagccaa tcccgctaac gacatggtgg agatcgctaa aacgtatgcc ggcatcgctc 1186561 cattttcaca tattcgcaat gtgaaaattt atgagaatgg cgattttatt gaaacatctc 1186621 atttaacaaa ggatggttcg atcaacattc aaggcgtgat ggaagaactg cataagcagg 1186681 attacgaagg atatgtcaga ccggatcatg ggcgccatct ttggggcgag caatgccgcc 1186741 cgggatatgg cttatacgat cgggcacttg gcatcatgta tttgaacggg ctgtgggacg 1186801 cttatgaagc aatggcaaaa aaagaggtgg gcatatgatc ccgctgcatg agaacctggc 1186861 tggtaaaacg gctgtcatca ctggcggcag cggcgtgctt tgctctgcga tggcccggga 1186921 gctagcccgt catggcatga aggtggcgat tttgaatcgg acggctgaaa aaggccaagc 1186981 ggtcgtgaag gagataacgg cggctggcgg cacagcgtgc gctgttgctg cggatgtgct 1187041 ggacaggatg tcactggagc gggcaaagga agacatcctt ggccaatttg gcgctgttga 1187101 tctgttaatt aacggggctg gcggcaatca tcctgacgcg ataaccgatg tggagacata 1187161 tgaagaagcg ggagaaggcc aatccttttt tgatatggat gagaggggct ttctaactgt 1187221 attctccacc aacttcaccg gtgcgtttct ggcctcgcaa gtgtttggta aagaactgct 1187281 gaaggcggat tcacccgcga tcatcaacct ttcttccatg agtgcttatt cacctatgac 1187341 gaaggttccg gcatacagtg ctgcgaaagc atccatcaat aattttacga tgtggatggc 1187401 tgttcatttt gccgaaaccg ggctgcgggt caatgcgatt gccccaggct tctttctgac 1187461 aaaacaaaat catgatctgc tgatcaacca agacggaacg ttcaccagcc gatctcacaa 1187521 aattattgcg ggaacaccga tgaagcgctt cggaaaaccg gaggatttgc tcggtacgct 1187581 cctttggctg gcggatgaat cctattccgg ttttgtcact gggatcaccg ttcctgtcga 1187641 tggaggattt atggcttatt caggtgtgta acgaaagcgg tgcaacagaa actgaaccaa 1187701 cataggggtg aggttgagat gttttcaaaa gataagcttc ccgttatcct ttttttgttc 1187761 ctggcagggg tgattaatta cctggatcgc tcggcgcttt ccattgcagc tccttttatt 1187821 caggatgatc tcacattgtc tgccacacaa atgggcttga ttttcagcag tttttcgata 1187881 ggttatgcca tttttaattt tcttgggggc gtggcatccg accgctatgg ggcaaagctg 1187941 accttgtttg tcgcgatggt tgtttggtcg ctgtttagcg gagcagtcgc cctcgctttt 1188001 ggctttgtca gcctgctgat tatacgcatt ctcttcggaa tgggagaagg cccgctttcg 1188061 gcgaccatca acaagatggt gaacaactgg ttcccgccga cccagcgggc gtccgttatc 1188121 ggtgtaacca acagcggcac gcccctcggg ggagccattt ccggcccgat agtcggcatg 1188181 atcgcagtgg cgttcagctg gaaggtatcc ttcgttctca ttatgattat tggattgata 1188241 tgggcagtgc tctggttcaa gtttgtcaaa gaaaagccgc aagagacgat caaggaagca 1188301 ccggcaataa aagcagaaac gtctcccgga gaaaaaattc cgctcacctt ttacctgaag 1188361 caaaaaacag tcctgttcac ggcgttcgct tttttcgctt acaactacat cctcttcttc 1188421 tttttgacat ggtttccgag ctatcttgtc gacgagcggg gattaagtgt tgaatcgatg 1188481 agtgtcatca cggtcatacc gtggatttta ggatttatcg ggctggctgc ggggggattt 1188541 gtttctgact atgtgtacaa aaaaacggcc cgaaaaggtg tgctgttctc gcgcaaggtt 1188601 gtgcttgtca cgtgtttgtt ttcatcagct gtcctgattg gttttgccgg gcttgtggca 1188661 acgactgcgg gggctgtcac tcttgtcgct ctgtcagtgt tctttcttta tttgaccggt 1188721 gctatctatt gggctgtcat tcaagatgtg gttgatcaaa acaatgtcgg ttctgttggc 1188781 ggcttcatgc atttcctcgc caacacggca ggaattatcg gcccggcttt aaccggattt 1188841 attgttgacc aaacaggcac gttttctgga gcatttttgc ttgccggtgg gctggctgtc 1188901 ttcgcttcac ttgctgtgat tcgttttgtc cgtccaatca ttggtaagcc agcgggaaca 1188961 gaagctgaga atcctgtgtc ttattaatct ggaaatatag tgggagaggc ggtatgtttg 1189021 atgatacaat atacagtaaa taatcgcagc cggtatgata aggaagggaa ttagatggta 1189081 accataaaag atatcgcaaa actcgcaaac gtatcccaca ctactgtttc cagagcactc 1189141 aacaacagcc cttacatcaa agaacatacg aagaaaaaaa tattagagct agcagagcag 1189201 ctcaactata caccaaatgt aaatgcgaaa agtctggcga tgcaaaagtc gcatacgatc 1189261 gggctattct ttacaagcat tacaaacgga acctcacaca gcttctttgc agacactatc 1189321 aaaggcgtca atcaagccat aagtgaggat tacaatctgt atgtgcgcgg cattgatgat 1189381 ctgaaaaact atgactccgt tacaccgatg agatatgacg gcatcatttt aatgagccaa 1189441 agtgacattg ataattcttt tatttaccat attcgcgaaa aaaacattcc gcttgtcgtg 1189501 ctgaatcgtg atattgatga tcgtaccatc acgaatattt tgtccaatga caaggaaggc 1189561 tctcaagaag ctgtagaata cttcattcag tccggacatc aagacatcgc catcatcgag 1189621 gggatcgaag gctttaaatc ctcccagcag cgaaaggaag ggtacttatc cgcactgatt 1189681 caacatcata ttccgatcaa gcatgaatac agtgtcaaag gacagtacga tatggaaagc 1189741 ggctttcaag cgatggagcg gctgctggca ctgccgaatc ctccaaccgc tgttttttgt 1189801 tcgaatgatg acatggcaat cggagcgatg aatgcgatat tcgcaaaggg cctgcgcgtt 1189861 cctgatgata tttcggtgat cgggtttgat gatattgggt tttcacagta catcacgcca 1189921 aggctttcaa cagtaaagcg cccagtggag aaaataagcg tgctcggtgc gcaaaaactc 1189981 ttgtcgctga tcagcgagcc cgaaacaaaa gcagaaaaaa tcttggaaaa cacagaattt 1190041 atggtgcgtg attcagtcag acgattgacg acgtgatgtc ccgtttttca gcgggcattc 1190101 tttatacaga aaaatgttaa cgtgtgcata aagtgagagg gaggcaataa gggtgcagaa 1190161 gctgaataaa aatgtgtacg atcactatac tcagtatcca gaaaaaattc tccaattcgg 1190221 agaaggaaac tttcttcggg gatttatcga ttggcagatt gatcaattga atcaacacac 1190281 tgattttaat gggagcgtgg cagttgtcca gccaagaggc tcagaaaaaa tcaaacgatt 1190341 aaatgagcaa gatggattat atacactttt tttacaagga atgaaagacg gagaagcggt 1190401 aaacgagcat atgattatca actcaatcag ccggggaatt gacctgtttt ctgattatga 1190461 agcatacaaa gaattggcat caagcgaaag gcttcggttt attatctcca acaccactga 1190521 ggctgggatt gtatgtgatg aaaaagatcg tttagaggat aggccgcaaa aaacattccc 1190581 tgggaaatta actgcatttc tttactttcg ctatcaggct tttaaaggag atcagacaaa 1190641 agggtgtgtc ctgatcccat gtgaactgat cgagaataac ggtgaaaagc tgagggaaac 1190701 ggttcttcat tatgcacatc tgtggaagct ggaggaagga tttacacagt ggattcatga 1190761 ggccaataca ttttgtaata gtttagtaga ccggattgtt ccgggttttc ccgtcgacag 1190821 cattgatgag atcacggcag atcttggcta tcaggatgat ttgatagttg tgggagagca 1190881 atattatttg tgggttatcg aggggcctga ttggattgga aaagaacttc cctttgcggc 1190941 tgcagggctg catacaaaga tcgtcagcga cctcacccca taccggacta aaaaagtaag 1191001 aattttaaat ggcgctcata cagcaatgac gccagtggct ttattatacg gcttgaagac 1191061 tgttagggat gcagtcgagc atccggaagt ggggcgattt ataagagagc tgattgatga 1191121 cgaaattctt cctgttttaa aaatggaagg tctttctcag tatgctgacg atgtgctgaa 1191181 ccgttttaaa aacccgtata ttaagcatta cctggaaagc attgcattga acgccatttc 1191241 caaattcaaa acgagaaacc tgccgactct taaggaatat gctgaacaaa agggacagct 1191301 tcctgaacgc ttggtgtttt ctttcagcgc tcttctgtat ttttatcatg ataacgagac 1191361 attgcaggat gatccggcag ttcttcaatt tttcaaagag gtttggtgtc aggaggatgg 1191421 cgacatgctt cggattgcat caagagtgtt aggcgaacag cggctgtggg gggcagatct 1191481 caatgagata ccgaagctga ctgatagagt cgctgtttac ttgaatcata ttcatgagct 1191541 gggcatgcag agggctcttg aacaatactg catacaaggg ggagaggtac gttgaagtcg 1191601 tttataaaga ttcataagca agataatgtc cttcttgctc tgcgggatat tcaaaaggga 1191661 gagaggctgc atgcttacgg cgtgtcgatt gaagtaaagg atgatataaa aagaggccat 1191721 aagattgcat tgcagtctat caaagaaaac gacagcatcg tcaagtacgg gtttccaatc 1191781 ggtcatgcat cacaagatat ctcgatcgga gagcatattc atgtccataa tacgaaaaca 1191841 aacctgtctg atatccaatt atacagctat acaccgagat ttgatgaaaa tccgtattct 1191901 aatgagaacc ggacgtttaa aggttttaga agagaaaacg gagatgcggg tgtacggaat 1191961 gaattgtgga ttgtcccaac tgtcggctgt gtcaatggaa tagcagaaaa aatgctgcag 1192021 cgttttgtca gagaaacagg ggatatcgct ccatttgata acgtactggt gttaaagcat 1192081 caatacggat gctcgcagct tggcgacgat catgaaaata cgaagcagat cctgctgaat 1192141 gccattcgcc atccaaatgc cggcggcgtc ttggtgttag ggcttggctg tgaaaacaat 1192201 gagctggcaa gaatgaagga agcactgcaa gatgtgaact tgaagcgggt gaagtttctg 1192261 gaatcccagt cggtgaccga cgaaatggag gcaggcgttg ctttgctgaa ggaaattcat 1192321 gaagcggcca aaggagataa gagagaagac attccgctgt ctgaactgaa gatcgggctg 1192381 aaatgcggag gttcggacgg tttttccggc ataaccgcaa acccgctgct tggacgtttt 1192441 tcagattatc tcattgcaca gggagggagt actgtgctga cggaagtacc ggaaatgttc 1192501 ggcgcagaaa ccatcctgat gcagcgggct gccaatgaag aagtgtttca taagatagtc 1192561 gatttaatca atgatttcaa acaatacttt attaaacatg atcagccggt gtacgaaaat 1192621 ccttcaccgg gcaacaaagc gggcggcatt tctacacttg aggataaatc gctgggctgt 1192681 acgcaaaaag cggggatttc tcctgtcacg gatgtcttga aatacggtga agtactcaag 1192741 acaaaagggc tgactctttt gagcgcaccg ggcaatgatt tgatcgcctc ctccgcattg 1192801 gcggctgccg gctgccaaat tgtcctcttt acaacgggaa gaggcacgcc gtttggcacc 1192861 tttgtcccga cggtgaaagt agcgacaaac accgagctgt atgaggcgaa gccgcattgg 1192921 attgatttta acgcaggcct tttagcagag gatgatgttc atgaggaata tgtgctgcgt 1192981 gagtttatcc actatatgat tgaggtggca agcggccagc ttgtgaacca tgaaaaaaat 1193041 gatttcaaag aactcgccat ttttaaatcg ggtgtgacgt tataataaga aaaggctatc 1193101 cttcaagcgg atagccttct tcattaaatc aattttaaac cgctgactaa aataatggaa 1193161 gccataataa attgcagtgg acgcggggag aatcgaggcg aaagatggct cccgatcagt 1193221 acgccgggaa ttgaaccgag gagcagatta gctgccagca tgtaatccac gcttccgaag 1193281 cttgcgttca aaatgcctgc tgccgtaaca agaagaaaag catgcgcgat atcggttccg 1193341 acaatctgtg acgctttcat gttaaataag taaatcatgg cgattgcaaa taatgagccg 1193401 gacccgattg atgttaatcc gacgataaac ccaaacacaa caccaataag aattgtcagc 1193461 gccctcttat tttcaagcgg catcagctgc cagcggttgg ggcgaagttt tctatccaaa 1193521 aacaaacgaa cgatgattga aatggcaacc agcgttaaca catatcctag agcgtgctta 1193581 ataatttctt cctgatgctg gtgaaaggcg gggaacaaat gcaatatgcc aatggctagc 1193641 gaagcactcg gaataccgcc gatggctaag tattttacca atttaaagtt aatcgttttc 1193701 tgccgccaat gggaggcaac gccaaacagc tttgtgatcg agttatatac aagatccgta 1193761 ccgaccgcga tggaaggatt aattccaagc acaattaaaa ggggagttaa taaggccgct 1193821 ccacccactc ccgtcaatcc gactaaggct ccgacaaaca aacccatcaa tatgatgctt 1193881 acactcatga taaaggcctc ctgaaaaccc gactagaatt cacccgaatc ttattcgcgt 1193941 tggtcaagta ttaattgtaa gtgctccatc ggctgctgaa aaacccgagc tctatccgct 1194001 ccctgatggt atcattcaat tgacaacacc ttatacatca ggagaacacg tctttcaggt 1194061 gcaacgagca cttgcggctc tgtattttta ccctgataaa ggcgctgtta acaacggaat 1194121 tgacggcgtt tacggaccga aaacagctga cgcagttgcc cgttttcagt ctgttaacgg 1194181 tctaactgct gacggtatct acgggcctgc gacgaaagag aagatcgcag cgcaattaag 1194241 ctgatcaaag accataaaaa tcccggagcc gctccgggat ttattttttc ttcttcaact 1194301 tttttataat tccagcactg cgctccctca cccgaagcga gtacccggaa agcccaaacc 1194361 ttccgtaatc aacaaacttc acacgcctca ccaatttttt cactgtatca cctgacatta 1194421 tcctctgttt gtatttatta tatgtcaccc tttaagaaaa ggaataagga caagagctgt 1194481 tttcccttgt ccttttagtg tgatcatgct ttttttcgtt tatactcgtc aatcagccgt 1194541 tcgttttctt tgaagattct tgctgtatgc ggactgactt gatagcttgc gacactggtg 1194601 gttgaacgtt ttttcaggat tttaaacggc ttcgccgctc tgggctcgca tctgttttga 1194661 aacgcacgtt ccattatcct tcaccttcct cctcaattgg cagcaccaaa tcatatatgc 1194721 tcgttaatga cgtaaatagc aaataatcaa attccgtgac aatgctgtca gacgtcagct 1194781 tgatgacata gttctgtgtc tcgatggtaa aagggatgag aaccactttt ccgtattggt 1194841 cgtaataaac atcctttcga tcgagccgtg tttgtacatc tgccggatca tccatatgct 1194901 cggttaaccg gtctttatca gcctgtgtcg aatagtggca aagagaagcc gttaagttca 1194961 ttttatcagc ataggttttc agcagcttat caataccttc agcataagca tctatacttc 1195021 cataataaac atggatcggt tcgtttttca ataggtattg gtatgttttc agccgattga 1195081 gatacatgtg gagcatttcg ttgttttctt caagaatttc tcttgtgtct gtttcaagct 1195141 cgctgccggc cagttttttg acatatgcac ttaagaagat aaaagcatca atcaaagcaa 1195201 aactgactgc gacaatgaga taccgttccc agtgggtaaa tagggaagtg ggctcatatg 1195261 tccagtatac catagcgccc agaacaaaca gcaaatacca agttttccga atggcggaca 1195321 ttttttcttt gaccttcgct tcgaaacgcc acgtggcata cacgtataac cccagtccgg 1195381 ccacgatgca ccagaccatg atctgaaaga ataaaaccat attcgaatcc ctcacatctg 1195441 aaataggttc tgcttattgt attcgagaga tccggatggt tttcctgttc catcaaaaaa 1195501 accgctcctt tgacagaagc ggtgtgacat taaaatatca tatttaaaat aaagtaggcg 1195561 atggcaccaa gtgtcgctga aatcggaagc gtgatgaccc atgtaatgag cattcgcttg 1195621 gccgtacccc agtttacgcc ttttacgcgg tgggacgcac cgacgccaag aattgatgaa 1195681 gaaatgacgt gggttgtact gaccggcaaa tgaataaacg tggcgccgaa aataatggct 1195741 gctccggtta agtcagcgga aacaccgttt accggacgga ttttcatgat ctttccgcca 1195801 acggttttga tgattttcca gccgccgatt gatgttccga gacccatggc tgtcgcgcag 1195861 gcgaattgca cccaggtagg aatatcatta gcagaagtat gtaaattcgc tgtgatgaga 1195921 gccattgtga taattcccat tgctttttgc gcatcgtttg ttccgtgtgt atacgattgc 1195981 agggcagctg ttacaatctg cactctgcgg aattgcttat tcgttttcgc caagttgctg 1196041 tctttgaaaa tcagcttaac gatgctataa agaataaaac caaggacaaa ggcaataatt 1196101 ggtgatagaa tcagtgcttc aatgatttta atgaagccct tatagtttaa cgctgcaaat 1196161 ccggctgccg caatggctgc accggcaata gcgccgatga tggcatggga tgagctgctt 1196221 gggataccgt agtaccatgt gataaggttc caggcaattg cagcgagtag cgcagccaaa 1196281 atgacaacag agccattttc cagcgtataa ggatctacga tgtctttcgt aatggttttg 1196341 gcaacacctg taaacgtcat tgctccgaca aagttcatca cagcagccaa tataatggca 1196401 tggcgcggtt ttaacgcttt tgttgatacc gaagtcgcaa ttgcgtttgc cgtatcatga 1196461 aacccgttga tgaaatcaaa cgccagagca caaatgacta ttagtatcgt taatattaat 1196521 agaatatcca tttttacccc tcgttacgcg tttttcataa tgatggtttc aagattattg 1196581 gcaacacttt gacaagagtc ggcgatttct tcaagcgttt cgtatatttc acgatattga 1196641 atgactttga ttggatctgt ttcatttccg aaaagattct ttaatgattt tctgtgcaag 1196701 ttgtcacaac tgtgctcata ctctttaatt ttgattgcgt gaggctgaat atcctttaag 1196761 cgattttctg ccagcagctc gatcgtaatc aaaatctctt tcgcacattc tctgatatat 1196821 ccgctgaatt tatcaatatg ctcgtctgat gaagtaattg agaaaatctc catcatggca 1196881 gagaaatgtt cgattccgtc aagcacatca tccaagctgt ttgtcagctg aaggatatct 1196941 tcgcgctcaa taggagtgat gaacgctttg ttaagctctt taatcatgac atgaacatga 1197001 ttgtcacctt ttgtttcata ttcctttaac gtatctgcaa attctttaag agtcgtttgg 1197061 ttagtgacct taaaattcac aaaatattct gcagtttcgt ctatgttctt tgcaatttct 1197121 gttaaaagga gtgagaactt atcttttttt cttcttatca ttaaaaaccc tccatagttt 1197181 gaatgaacaa tgcacacatc aaattattat atagcctttt gtcgaaaaaa aacaggtaaa 1197241 gtcgaaaaaa acgtatcttg acttttttga taaatcgtgt ctccttattt tgacctactt 1197301 cgctttaaaa aaacgaccca agtttgcaaa aactttctgc ttaacgtaaa aagtatatca 1197361 aaagttgtgt ttttcctgtc aacttttatc ttctgtttca ccaaaaaacg gttccctaaa 1197421 caagggaacc gttttatcag cttgcttttc gttttttcat cccgtaataa acaggcagtc 1197481 cggcaaggcc gatgaggatg gataatccgc agctcattgt atctgtaatg agtgtgctgc 1197541 ctaacacaaa gaaggagccc gcgattgcca gaattggcat aaatggataa agcggaacac 1197601 tgtaggcgcg cttttctccc tttgctcgct tgcggagaat aaacactgca aaaaaggcca 1197661 tcacataaaa aatgtagatc atgaaaatgg agatttctga gagcttatca gggttgctga 1197721 tcagcatcat aatcaaagcc aaagcaattt gaaaagaaat cgcaatccat ggtgtgcgga 1197781 acgacgggtg tacatgtgac agtttttcag caaatggaag ctgtttgcgt tccgccattg 1197841 caaatgaaac acgcgggaaa gaaagcacct ttccatttaa gcacccaaag atgctgacga 1197901 taatccctac actgatcagc tttccgccaa ttgaaccgaa cagcatggtt gcagcggtgc 1197961 ttgtcgcatt ttcaccaagc gtgacaattt cgttcgctga caggatgtga agcaatgcaa 1198021 aattaatgaa aatatagatc gccgttacaa ttaataatcc gcccgtcata gcgcgtggca 1198081 gcagcttttc gggatttttc atttctccgc cgagagcggc aaggagaatc catccgtcat 1198141 aagcaaacaa cgtagctaaa atagccgccc cgaagttcat atcagaaatg ctttcgttta 1198201 ctgctgtgaa gatgtgctga tcgcctttcc aaaggccaaa gacgatgatg caggcaatcg 1198261 gaatcagttt tccgatcgtt gtcagcgttt ggacaaaacc gccgtatttt gtaccgataa 1198321 tattaatgac gcataaaaag agaactgcta taattccaat gacttttgat agtccagatc 1198381 cccagccgaa aagattcgcc attaaagatc caaaatataa acccagcgcg ccaataatcg 1198441 ccgggccgta aatgataatc tgcacccagc cgcacaaaaa tccccaaaac tcgccgtaca 1198501 cttcttcaag gtacgtataa agcccgccgg tttttggaat ctgcgttccg atttccgcga 1198561 ttgtcaaacc gcccgccagt gttaaaatac cgcctaacag ccaggcgaaa agcgccattt 1198621 ttgaatcacc tgaataagca agcacagcgc cgggcttcat aaaaacacca gaaccgataa 1198681 tggttccgat gacaagagta agggcaaaca agaggcctat ctcttttttc aaaccgttgt 1198741 cttcagtatg catgtcctta acctcctatg atgttgaagc ttcatgttga agaatctatt 1198801 ttttcatatt gtaaacccta ttttagaaaa gtgaaataaa ataaattttc tgattttcga 1198861 aatttgcttt gtgtacagca gataaaactg tagaaatacc tgttttaatg gtctataaac 1198921 gaataaaatt cataattttt atttacaaag ttcgtgtttt atgtattagg attttagccg 1198981 gtacagaggg gagatgagaa ttcagaaaat gaacgaacct tcggtgaagc tgatatgttg 1199041 actttctcat gcgaataaaa tactttgtta ttagaacaat aaatatacaa ttatgatatg 1199101 atatctcgaa atcgagataa aataacctgg agggacagca tatgaaagtt aacggcattc 1199161 accacgtatc ggcattaacg gccgacgcac aaaaaaactt ggatttctat aagaaagtat 1199221 taggattaaa gctcgtcaaa aaatccgtca atcaggatga accgacaatg taccatctgt 1199281 tctacggaga tgaagtggca aacccgggaa ctgagctgac gtttttcgag attccccgca 1199341 ttgcaccgtt tcatgcggga acaaacagta tttcttctat tggattgcgc gttccaggca 1199401 cagaagccct gcattactgg aaagaacgtt ttgaagagca gcaagtaacg cacagcggca 1199461 tctccaaaag agccggacgt gacatattgg catttcaaga tcatgagggg cagcgacttg 1199521 tgctgactgc tgatgaggaa ggaaaaggat atggcctgcc tgttaaacag agcggcattc 1199581 cggaagaatt ttcgtttcgc gggttagggc cggttgaact gactgtgcca tatgctgaac 1199641 caactttaca cgtattgacg aatattcttg gatttacaga aatcagccgt gaaccagtcg 1199701 aagggcaagg aaccgccgtt attctggaat caggagaagg cggtgctgca acggaaatcc 1199761 atttaataga aagaaacgat cttccgcgag agcgtcaagg caaagggagt gttcaccacg 1199821 tcgcatttcg ggtaagagat gaagaagaac ttgccgggtg gcaccggatc atcagccgcg 1199881 aaggctttag caattcaggc atagttgagc gctactattt caaggcgctg tatttcagag 1199941 aaccgaacgg cattttgttc gagttatcaa cagacggacc gggctttatg gtagatgaaa 1200001 atcttgatga gcttggccaa acgattgctc ttccgccata tctagagcat cgaagagcag 1200061 aaattgaagc aaaattgaaa ccgatccaat aaattgtgat tcttttgcct tccggcgccg 1200121 ccggagggct ttttttatta ccataattaa ttttgaccta aacagcatgc cttattaggg 1200181 aggaaatatc agatgctgat tgggagaaat ggcttaaaac cctttgcaaa tatgggtgat 1200241 tggtatggaa tggcctcggc aaaaatattg tctttgttta ttaatagttt attcatattt 1200301 gcttgttaca ctatttcaaa gttagacaaa aaggagtgaa aaataagtgg aaaagaaaaa 1200361 acgcgagctg gatatcgtcc tcctcctcat tttgctcgca tctgcattct taaatatcta 1200421 taacatttgg aaggacgaca cggtgaatcc ttattacacc gcggcagtta caagtatgat 1200481 gcaaagcttt cataatttct tttatgcttc gttcgatgct gccggcttta taacagtaga 1200541 taaaccgcct gttacatacc aaatccaaac gatcagcgca ctgatattcg gtatgcacgg 1200601 ctggagcgtc atcctgcctc aggcacttgc tggtgtaggt tctgtccttc ttatgtactt 1200661 gctgataaag ccgacatttg gaaaaacggc ggcgcgtatt gcctcatttg ttatggcatg 1200721 tacgccgata gctgtagctg tagcacgtac aaacaatgtt gatgcattac tggtattttt 1200781 cttattgctt gctacatggc ttctctttaa agcgatcaga aaaggaaagc tgatctggct 1200841 gttagcagca tttttcgttg ttggagtagg ttttaataca aaaatgctgc aggcttacat 1200901 gattttaccg gctttcttat tgttctatct gattgcggca aacgccacaa tcaagaaaaa 1200961 aatcgtttca ttggtaagtg cgttagccgt attagcagcc gtttcgttat cgtggccgct 1201021 cattgttgac aatatccctg caagcaagcg gccttatatc ggaagcagcc aaaccaactc 1201081 tgttttggaa ttggctttcg gctataacgg aatccagcgg ctgacaggcc aaaattcagg 1201141 cggcggccag ggtgcgccaa acaaagacgc ttcaaaagaa atgtcttctt ctgataacac 1201201 tcaagcaccg cctaatcagt catcaagcaa cagctcatca agcgatggta aatcctcaaa 1201261 tggcaatatg gcggcgcctc catccaatgg ccaaatgcca agcggcggtc aaggaggccc 1201321 tccaagcggc ggagatggcg gccaaggcgg acccggcgga gacggaggga aaggcggtac 1201381 aggaaccggt tcgaaaatgc aatcaggttc agggatgttt ggaacgggaa cacctggtcc 1201441 actgcggctt ttccaacaag agttatctga tcaaatcagc tggcttctgc catttgcgat 1201501 atttggaatc gcaggcttac tgatcgctgg cgcaagagaa agaagaagat tatctgtaga 1201561 gcagaaggaa acggtgttct gggttgcgtg gcttgtaccg attgccggat tcttcagtgt 1201621 cgcagaattt ttccatcatt attatctcat catgctggca ccgccgattg cggctcttgt 1201681 cggtgcgggg tgggtcgctc ttgttcatct gtaccgcaat cagacaggct ggaaagcatg 1201741 gcttttgccg ggagcaatta ttgcgacaac tggatttgaa ttgtttattc tcagaaacta 1201801 caacgatcaa atcggtgttg gatggagtat cggggtaggt gttatcggcg tgttgtcagc 1201861 gattgctttg ctgctgttta aacagcgcca aaaaccgttc agttattatg tttcacttgc 1201921 agctctcctc gcattgctgg tgatgccgat gtattgggca agtacaccgc ttctgtacgg 1201981 aggcaacagc tcactgcctg aaacaggccc tcaactcgca tcaatgagcg gaaaaggcat 1202041 gggaatgtct gatgcgactg taaatgaaaa actgatcaaa tatctagagg agaataactc 1202101 cggagctgaa tacctattcg ccacaaccga ttcgaacaca gcggcaccat atatcattaa 1202161 aacgaaaaaa gctgtcatgg ctattggtgg atacagcggt tctgacccgg caatcacact 1202221 gactcaattc aaaaaacttg taaaagaagg aaaagtgaaa tacttcttgg cttctggaat 1202281 gggaagaggc ggaaacaatg acattgttga atgggttgag aaaaatggaa aagaagtagc 1202341 atcagaaaaa tggcaatcaa gttctgatca aaaaacagaa aatactgatt cagctgatac 1202401 atcaagcagc aaggcttcag gtgaaaacgg caaaatgggc ggacctggcg gaatgaatca 1202461 gtcagcaaca ttatacgaac tacatgctga tgaataggag gcaaaaacat gagcagacat 1202521 attcaatatt caattgttgt acctgtgtat aatgaagagc ttgtcattca tgaaacctat 1202581 cagcgcttaa aagaggtcat ggatcaaacg aaggaaaact acgagctgct ttttgtcaac 1202641 gatggcagca aagaccgcag tattgagatt ttaagagagc acagcctgat cgatccgaga 1202701 gtgaaaatta ttgatttttc aaggaatttt ggacatcaga tcgccattac ggcaggtatg 1202761 gattatgcac aggggaatgc aatcgtcgtc attgacgccg atttgcagga ccctcctgaa 1202821 ctgattttag aaatgattga aaagtggaag gaaggctatg aagtcgtgta cgccgtacgg 1202881 actaaacgaa aaggggaaac ctttttcaaa aaacaaaccg cggctatgtt ttaccggctt 1202941 ctcagcggta tgacagatat tgatatcccg attgatacgg gggattttcg cctcatggac 1203001 agaaaagtct gtgatgaaat gaagagatta aaagaaaaaa atccatttgt aagagggcta 1203061 gtcagctggg tgggtttcaa acagacagcg gtcgagtatg tacgtgatga aaggctcgcc 1203121 ggagaaacaa agtacccgct caagaaaatg ctgaagctgt caatggacgg catcacgaca 1203181 ttttcacata aaccgctgaa gctggcaagc tatgcgggga ttttaatgtc aggtactgga 1203241 tttctgtata tgtttatcgt gctgtatctg aagctattca cagacagcac gattaccggc 1203301 tggtcatcac ttattgtgat ccagctcctg ttcagcggca ttgtccttct gattttgggc 1203361 gtgattggcg aatatatcgg cagaatctac gatgaagcca aagacaggcc gctttacatc 1203421 gtccaaaaat cgtatggaat tgaaaataaa agactctata gagaccagca tatgtcataa 1203481 cctcaaaccc cctgtccgta atggacaggg ggtttttatg ctctgagcac gatctaaagc 1203541 aaaagatgct gatagatata tggaaattgg gtaaagaaga gattgtgagc ttgtactgcg 1203601 gttcagtcat gctgaaataa aaacagcaaa acttaaagat ttcgtcctcg gctttgctgc 1203661 atgtcagctg ttatattggg gggcttttaa gaaacgcatg attagagccg taccagttat 1203721 gtttaataga atactcgtac ccaatacaat tccccacgtc aacgtcgatt cagagagaag 1203781 aaagctcagc aaaagaaaag ccaatcctgc gcagatcata cccagtccca cggttttcat 1203841 gttcatgcct cctagcaaac gatgtttcta gcatctgatg tgaatgatgt caatctgtat 1203901 gatatacgga tatctcgtca gaaagtttca tagaacaatt aggtctttta tctaataaaa 1203961 agcctcagac cgcttttacg gcctgaggca ttatgtctta cgaagttttc tcttcttttt 1204021 gatccagttt aatttttttc gtcatttctt tgccgtttcg gagaattttc acttcaacgg 1204081 tatcaccgat ctttgcgtct ttatataaga tattgcgcaa ttcactgcct gtatcaattt 1204141 ctttaccttt taggccgatg ataatatcct ccgcttttaa tccggccttt tcagcaggag 1204201 agcctgaagc gacctcacgg atgtaaacgc ctttattcag ctggctgccg aacaggccga 1204261 gtgtgccttc ttggtaattt tgcggcactt gctctagatc aagcatgctg acaccgatat 1204321 atggacgttc aatttgtcct ttagacagca attcttcagc aatcggtttt acgtcattgc 1204381 ttggaatggc gaatccgata ccctcaacat catcctcact gattttcata ctgttaatgc 1204441 cgacaatttt gccgtctgta tttaacaaag gaccgccgct gttacctgga ttaattgctg 1204501 cgtctgtctg aatgacgtta atgctcgttt cgccggctga tgtagacatt gaaaccgttc 1204561 tgtccacgcc gcttacaatt ccttgtgtta ctgtgcggga caggtctttt ccaagcggat 1204621 ccccaatcgc aataacggtc tcgcctgttc taagatcaga tgaatcaccg aagtttgcca 1204681 cttttgtgac gtggtcatca ctgatttgga ggacggctaa atcagttaac gagtcactgc 1204741 ctaccagctt tgcagtaacc tcagtgccgt catataaaga taccttcagt gatgatgccc 1204801 cttctacgac gtggttattt gtaatgatat aagccttgcc attctctttt ttgaaaatga 1204861 cacctgaccc tgaaccgctt tctgtatctt cgctggaatc agaagaacta gagccgaaca 1204921 aagagctgtt tgattgtgcc tgaagatttg taataccgac aatcgctggt gaaaggtctt 1204981 ctaccatatc tgagatttta gaagagtcct cgctcttgaa tgcagatgag ctgcttgagc 1205041 tttttttaga ttcagaggag gtgcttgttg ctgtaacaga ttgcgtttgc tgctggctgg 1205101 atgattgttt tgcagtgtcc tgagaatcat ggtcaccaag cggtgtaaac gtgtaaatgc 1205161 caagagcaag actgccgccg atcactccgc caagcaacgg tctgaaccat ccgaatcctc 1205221 gttttttctt ctcctgatca tgaatgacat tgcgggccga gtaggaggcg ctctgatcgt 1205281 tctctttcgt taaaaagacc tcattctcat tacctttcgt tctgttttca tcacgatagt 1205341 tatccatcat gttcactccg tttctctatt ttcacatgtc tatttatatt gataggttta 1205401 tgacttgagt ttatcataaa caaaaactgt gggataaaaa tgaaaagatt atgggaaatt 1205461 gtgaaaaagt gcggaaaacg gtacacttca tattgtatat gaaaggactg agtcgatgga 1205521 acagattgga ttgattggat atggcagcat ggcggatatg atcgctagac agctgttgaa 1205581 acatgaacaa ataaaagaga atgagctatt tattgagacg agaacgaagg gggagcggct 1205641 gcgggcactc atgtcagatt atccaaacgt atcggctgat ccgttggaga attgggcaaa 1205701 tacgtgccaa ttgattttga tatgcgtccc gccactccat gtcatcgaaa caatgcgccg 1205761 tctgtacccg tatgtgaaca gaaatactca catcgtatcc atagctgccg gtgtgccgct 1205821 gcgtcttttg gaggcagaaa cagaagccgg tatctcacgt gttattcctg ccattacgtc 1205881 cgaagcagaa gccggcatct cacttgtcgt tcacagtgaa gcactggctg cagagaaaaa 1205941 agaacgtctg aatgaattgt tatcggtttt cagccgtgta cgggaaatca aagaatcgaa 1206001 tttagatgtg gccagcaatt taacgagctc ggcaccggga ttcatagctg caatctttga 1206061 agaactggca ctgtctgccg tcagaaacag cagcctgtcc aaagaagaag cctttgattt 1206121 tctgattcat tcgctatacg gaactggcaa gatgctgatc gaaaaaaata tgtctttcga 1206181 ggagacgctg gaacgtgttg caaccaaagg cggaataacg ggagagggag ctgaggtgat 1206241 acacgcctct gtgccggacg tttttgatga ggtatttgaa agaaccctga gaaaatatga 1206301 actgcttaca gaacaggttg gtaaacaaac atgaatcctt gaaagaggat tcttttttta 1206361 tcactgaatg attgagattt ttcccagtta tattgcattt ttcctctttt tttaatataa 1206421 tttgttagaa tattcataat ttagtaaaaa aggaggagcg ttatgaaatt gtacatgtca 1206481 gtagatatgg aaggtatttc gggtcttccg gacgatacct ttgtggattc cggcaagcgg 1206541 aattatgaac gcggacggct tatcatgact gaagaagcaa actactgtat tgctgaagcg 1206601 tttaacagcg ggtgtaccga ggtgctggtc aatgacagtc attcgaagat gaataatctg 1206661 atggttgaaa agcttcaccc tgaagcagac ttgatttctg gtgacgtcaa accattttca 1206721 atggtggagg gactggatga tacgtttaga ggcgctttgt ttctcggtta tcatgcgaga 1206781 gcctcgactc ctggtgtcat gtcacacagc atgattttcg gcgtccgtca tttttacata 1206841 aacgatcggc ctgtcggtga gcttggatta aatgcatacg ttgccggtta ttatgatgtc 1206901 ccggtattaa tggtagccgg ggatgaccgg gcggcgaagg aagcagaaga gcttatcccg 1206961 aacgtgacga cagccgcagt caaacaaacc atttcaagat ccgcagtgaa gtgcttgtcg 1207021 cctgcgaaag ccggacggct gttgacagaa aaaaccgcat ttgccctgca aaacaaggac 1207081 aaagtcaagc cgctcacacc gcctgacagg ccagttctga gcattgaatt cgccaattat 1207141 ggccaagcag aatgggcgaa tctgatgccg ggaacggaaa tcaagacggg aactacaacc 1207201 gttcaatttc aggcgaagga catgcttgaa gcctatcagg cgatgcttgt catgactgag 1207261 cttgcgatgc ggacatcatt ctgctaaagg ggtgttttag gctttggcgc gatacatgat 1207321 aaagcgtttt tgggcaatgg cagctacgat tttggtgatt accaccctga cttttgttct 1207381 catgaaggtc attcccggat ctccttttaa cgaggagaga ggcacaaatg aagccgttca 1207441 aaaaaatctc gaagcctact atcacttaga cgatcctctc attttccaat acattttcta 1207501 cttaaaatcc atcattacat tcgatttcgg accttcaatt aaaaaaccgt cggacagcgt 1207561 aaatgatatg ctggaacgcg gatttcccgt ttcctttgag cttgggatga cagcgattgt 1207621 cattgctgtg atttctgggc tggtgctggg cgtaatcgct gcactccgcc gcaatggctt 1207681 tttggactac gccgcgatga gtcttgcagt actcggcatc tccatcccga attttattct 1207741 ggcaacattg ctcattcagc aatttgctgt caatctcaaa ctatttcccg ctgcgacatg 1207801 gacgagcccg attcatatgg tgcttccgac cgcagcgctt gctgtagggc caatggcgat 1207861 cattgccagg ctgacacggt cgagcatggt cgaagttctg acacaggatt atatccgcac 1207921 agcaaaagca aaagggcttt ctccgttcaa aattatcgta aaacacgcac tcagaaatgc 1207981 actcatgccc gtcattaccg tcctgggcac actcgtcgcc agcatcttaa caggaagctt 1208041 tgtcattgaa aaaatctttg ccattccggg aatgggaaaa tattttgttg aaagcattaa 1208101 tcagcgggac taccccgtga ttatgggaac gaccgttttt tacagcgtca ttctgattat 1208161 catgctgttt ttggtcgatt tggcctacgg tctcttagac ccgcgcatta aactgcataa 1208221 gaaagggtga agcgtgtgaa tctccctgta caaacggatg aacgccagcc agaacagcac 1208281 aatcaggtgc ctgatgagtg gtttgtcttg aatcaggaaa aaaatcggga agccgattcg 1208341 gtcaagcggc cgagtttgtc atacacgcag gatgcctgga ggaggctgaa aaaaaataaa 1208401 ttagcgatgg ccggactctt tattctttta tttctttttg tcatggcagt tatcgggccc 1208461 tttttatcgc cccatagtgt cgtacgccaa tcgctgacag aacaaaatct tccgccctca 1208521 gccgatcatt ggttcggcac cgatgaactc ggccgggatg tgtttacccg aacatggtat 1208581 ggcgcgagaa tctcgttgtt tgtcggcgtg atggcagcac tgattgattt tttgatcggt 1208641 gtcatttacg gaggcgttgc cggctataaa ggcggcagga ttgacagcat tatgatgcgg 1208701 attatcgaag tgctgtacgg actgccgtat ctgcttgttg tcattttgct gatggtgctc 1208761 atgggaccgg gactgggcac gattattgtg gcgctgactg tgaccgggtg ggtcggcatg 1208821 gcgagaattg taagaggcca ggtgcttcag attaaaaatt atgaatatgt actcgcctcg 1208881 aaaacctttg gcgcgaaaac ctttcgcatc atccggaaga atttgctgcc gaatactatg 1208941 ggagcgatca tcgtacaaat gacattaacc gtacctgccg ccatattcgc agaatcattt 1209001 ttaagctttc tcggcctggg catacaggct ccgtttgcaa gttggggcgt gatggcgaat 1209061 gacggcctgc ctacgatttt atctgggcat tggtggcgcc tgttttttcc ggcctttttc 1209121 atatctctga cgatgtacgc gtttaatgtg ctgggggacg gattgcagga tgcgcttgac 1209181 cctaagctga ggaggtagct gtatggaaaa agttctgtca gtccaaaatc tgcacgtgtc 1209241 ttttacgact tacggcggga cggttcaggc ggtcagaggg gtgagctttg atttgtataa 1209301 aggagaaacc tttgcgatcg tcggcgaatc cggctgcggc aaaagcgtta cctcccaaag 1209361 catcatgggc ctgcttccgc cttattcggc gaaggtgaca gacggcagga ttctatttaa 1209421 aaacaaagac ctttgccgtc tctctgacaa agaaatgaga ggtataaggg gagccgacat 1209481 ttctatgatt tttcaagacc cgatgacggc gttaaaccct acgctgactg tcggcgacca 1209541 gctgggggaa gcgctattgc gccacaaaaa aatgagcaaa aaagcggcac ggaaagaggt 1209601 gctttccatg ctgtcattgg ttggtattcc agatcccgga gagcgcctaa agcaatatcc 1209661 ccaccaattc agcggcggta tgagacagcg gattgtcatt gcgatggcgc tgatttgcga 1209721 gcctgatatc ttaattgcgg atgaaccgac caccgccctg gatgtaacca ttcaggcaca 1209781 gattttagag ctgtttaaag agattcagag aaaaacggat gtgtctgtca ttctgattac 1209841 gcacgattta ggggttgttg cccaggtagc tgacagagtc gcagtcatgt atgccgggaa 1209901 aatggcggaa atcggcacaa gaaaagatat tttttatcag ccgcagcacc catatacaaa 1209961 aggcctgctg ggctctgtcc cgcggctgga tttaaatggc gctgagctga ccccgattga 1210021 cggaacgccg ccggatttat tttcgcctcc gccgggctgc ccgtttgccg cccgctgtcc 1210081 gaacaggatg gttgtgtgtg acagggtgta cccgggccag acgatcagat ctgactcgca 1210141 caccgtcaac tgctggctgc aggatcaacg agcagagcat gcggtgctgt caggagatgc 1210201 gaaggattga acatgaaaag ggggaagagg atgaaacgag tgaaaaagct atggggcatg 1210261 ggtcttgcat taggactttc gtttgcgctg atggggtgca cagcaaatga acaggccgga 1210321 aaagaaggca gtcatgataa ggcaaaaacc agcggagaaa aggtgctgta tgtaaataat 1210381 gaaaatgaac cgacttcatt cgatccgccg atcggcttta ataatgtgtc atggcagccg 1210441 ttaaataaca tcatggaggg gctgacgcgt cttggcaaag atcatgagcc cgagccggca 1210501 atggcggaga aatggtctgt ttcgaaagat aataaaactt acacatttac gattcgggaa 1210561 aatgcgaaat ggacaaacgg agatcctgta acagccggag acttcgaata cgcgtggaag 1210621 cggatgcttg atccgaaaaa aggcgcttca tcggcattcc taggttattt tattgaaggc 1210681 ggcgaagcat ataacagcgg gaaagggaaa aaagacgatg tgaaggtgac ggcaaaggat 1210741 gatcgaaccc ttgaagttac actggaagca ccgcaaaaat atttcctgag cgttgtgtcc 1210801 aatcccgcgt atttcccggt aaatgaaaag gtcgataaag acaatccaaa gtggtttgct 1210861 gagtcggata catttgtcgg aaacggcccg tttaagctga cggaatggaa gcatgatgac 1210921 agcatcacaa tggagaaaag cgacacgtat tgggataagg atacagtgaa gcttgataag 1210981 gtgaaatggg cgatggtcag tgacagaaat acagattacc agatgtttca atcaggggaa 1211041 cttgataccg cttatgtccc tgctgagctg agtgatcagc tgcttgatca ggataacgtc 1211101 aatattgttg accaggcggg tctctatttc tatcgattta atgtcaacat ggagccgttc 1211161 caaaatgaaa acatcagaaa agcctttgcg atggctgtgg atcaagagga aattgtaaag 1211221 tacgtcacga aaaataatga aaaaccggcg cacgcctttg tatcgcctgg gtttacgcag 1211281 cctgacggca aagatttccg tgaagcaggc ggagacctga tcaagcctaa cgaaagcaaa 1211341 gcgaagcagc tgctcgaaaa gggcatgaag gaagaaaact ataataagct tcctgcgatc 1211401 acgcttactt acagcacaaa gccggagcat aaaaagattg ccgaagctat tcagcaaaaa 1211461 ttgaaaaata gccttggagt cgatgtgaag ctggccaata tggaatggaa cgtattttta 1211521 gaggatcaaa aagcgctgaa attccaattc tctcaaagct catttttgcc tgattatgca 1211581 gaccctatca gttttctgga agcctttcaa acgggaaatt cgatgaaccg cacaggctgg 1211641 gccaataaag aatacgatca gctgatcaaa caggcgaaaa acgaagccga tgaaaaaaca 1211701 cggttctctc ttatgcatca agctgaagag ctgctcatca atgaagcgcc gatcattccg 1211761 gtttattttt ataatcaggt tcacctgcaa aatgaacaag taaaaggaat tgtccgtcac 1211821 cctgtcggct atatcgattt aaaatgggca gataaaaact gatggaggcg attgaggaaa 1211881 tactgcttct ttatgcgaag gagcggtatt ttttctcttt cttgcacgta tacgtagggt 1211941 gcagagcaaa tgaaaggagt gttttcgttg aattacaagc cgaaagcgtt gaacaagggt 1212001 gatacagtcg gagtgatcgc gcccgcaagt ccgccggatc caaaaaagct tgacaccgcg 1212061 cttttatttt tagaagagct cggtcttcag gtgaagttgg gcaaggcgct gaaaaaccag 1212121 cacggctatt tagcgggaca ggatgatgag cggctggcgg atctccatga gatgttcaga 1212181 gacgatgagg taaaagcagt gttgtgcgca tgcgggggtt ttgggacagg acgtatcgcc 1212241 gcgggcattg atttcagctt gatccgcaaa caccctaaaa tcttttgggg atacagcgat 1212301 attacgtttt tacatactgc cattcatcaa aacacaggtc ttgtcacttt ccatggcccg 1212361 atgctcagca cggatattgg ccttgacgac gttcacccgc tgacaaaagc gtcatataag 1212421 cagctcttcc aggagacgga attcacctat acagaagagc tttctccgct gaccgagctt 1212481 gttcctggaa aagcggaagg cgagcttgtc gggggaaatc tgtctttgct gacgtctaca 1212541 ctgggcacgc catttgaaat tgatacgaga ggaaagcttc tgtttattga agatattgac 1212601 gaggagcctt atcaaatcga ccggatgctg aatcagctga aaatgggggg gaagctgacg 1212661 gacgcggcgg gaattctagt ttgtgatttt cacaattgtg tcccggtgaa gcgagagaag 1212721 tctctctcgc ttgagcaggt gctggaagac tatattattt ctgcgggcag gcctgctctg 1212781 agaggattta aaatcggcca ctgctcgcca agtattgccg ttccgatcgg tgcgaaagct 1212841 gctatgaata cagcagaaaa aacagccgta atagaggcgg gcgtttcaga aggggcgctg 1212901 aagacatgaa aatcattcga atcgaaacaa gccgaatcgc tgtcccgctg acaaagccgt 1212961 ttaaaaccgc acttcgcact gtgtatacgg ctgaatcagt catagtaagg attacttatg 1213021 acagcggtgc agtcggatgg ggagaagcac ccccgacgtt agtgattaca ggagacagca 1213081 tggatagcat tgaaagtgcc atccaccatg tgttgaagcc ggcattgctt ggaaaaagcc 1213141 tggcgggcta tgaggccatt ctgcacgaca tccagcatct tcttacagga aatatgagcg 1213201 cgaaggctgc tgtagaaatg gctctatacg acggctgggc gcagatgtgc gggctgccgc 1213261 tttatcaaat gcttggcgga tatcgagata cgctggaaac agattatact gtcagtgtca 1213321 actcacctga agagatggca gctgatgccg agaattatct caaacaaggc tttcaaacgc 1213381 tgaaaataaa ggtcggaaaa gatgatattg caacagatat cgcccgtatc caggaaatca 1213441 gaaaacgtgt cggatcagct gtgaaactgc gtttagacgc taatcagggg tggaggccga 1213501 aggaagcggt aactgccatt cggaaaatgg aggatgcggg cctaggcatt gagcttgtcg 1213561 agcagcctgt ccataaagat gatctcgctg ggcttaaaaa ggtgacagat gcaacagata 1213621 cgccgattat ggctgatgaa agtgttttta caccgcgcca ggcgttcgaa gttctgcaaa 1213681 cccggagcgc agacttgatc aatattaaat tgatgaaagc gggcggcatc agcggagcag 1213741 agaaaattaa tgccatggcg gaggcctgcg gggtggagtg tatggtcggc agcatgatcg 1213801 aaacgaagct gggcattacg gccgcggcgc attttgcggc aagcaagaga aacatcacac 1213861 gctttgattt tgacgcgccg ctgatgctga aaacagatgt attcaatggc ggcataacat 1213921 atagcggcag cacgatttcg atgcctggca aaccgggcct cggaatcatc ggggctgcgc 1213981 ttttgaaagg ggaaaaagag caatgatgca cactgtcata tcagcagtgg ccaacatctg 1214041 gacagcgcct gattcacctc gtccgtctga tcaattcatg cttcaaccga ctgtaatgat 1214101 cagagactgg ctggagcgca tgacgtatga tgaacggctt ggattatgta cagacaatgt 1214161 aatccaaact caggttctct ttggcgaaaa ggtacttgtg acggcggaac agggggaatg 1214221 ggtttctgtg atcgtgccta gccagccatc ccgaaaggat ccgcgcggat acccgggctg 1214281 gatgaaaaag taccagctgg aaaaaacaaa gcccatccat acacaacacg atgtgatgat 1214341 cagcaaacct gctgcctttt tgtacagaag caatggggaa aaggagatcg aattaagctt 1214401 tttgacagtt ctgcccctta ttgcaaaaga aaacggatat tttaaggttt cgaccgtttt 1214461 tggggaaagg tttgtgaggc aaagtgatgc agtgcctgtc agccaacaga aagggactgc 1214521 tgaagacatc attcaaacgg gtgcgttttt tcttggcctt ccctacctgt ggggagggat 1214581 cagcgggttt gggtttgatt gctccggatt tatgtacagt atatttaagg cgaatggata 1214641 cagcatcccc cgtgatgcgg gagatcaggc taaggcaggg aagggtgtcc cgcttgatga 1214701 tatgaaagcc ggtgatctgc tgttttttgc ttatgaggaa ggaaaaggag cgattcatca 1214761 cgtcggtctg tatgtaggcg gcgggaaaat gcttcattct ccaaagacag ggaagtcaat 1214821 cgaaatcctc acattaacag agacaatcta tgaaaaagaa ttatgtgcgg tgcgccgctg 1214881 tttttcagaa taaggaggga gacaaatgag gcgactgcct ttgttagagg tcagccagct 1214941 gaaaatgcat tttgacgcag ggaaaaagcg gacagtcaaa gctgtcgacg gggtcacctt 1215001 tcagattcgt gaaggagaaa cgttcgggct agtcggggaa tcagggtgcg ggaaatcaac 1215061 cttggggaga gtgctgatgc gcctttatca gccgacagaa ggaagcgtga cataccgcgg 1215121 cacaaatctt catgcactaa gtgaaaaaga gcagtttgcc ttcaaccgca aactgcagat 1215181 gatttttcag gacccttatg cttcacttaa cccgcgcatg accgttcgag aaattatttt 1215241 ggagccgatg gagattcata atctctacaa tacccataaa gcacggcttc tcgtcgtgga 1215301 cgagctgctt gaggcagttg ggcttcaccc cgattttggc agccgttatc cgcatgaatt 1215361 cagcggcggg caaaggcaga gaatcgggat tgcgagagca ctgtcgctga atcctgaatt 1215421 tatcgtggcg gacgaaccga tttctgcact tgatgtctct gttcaagcgc aggtggtcaa 1215481 cctgctgaag cggcttcaaa aagagaaagg gcttacgttt ttattcattg cccatgatct 1215541 ttcgatggtg aagcatatca gtgacaggat cggtgttatg tacttaggac acatgatgga 1215601 aattacagag agcggcacct tgtatcgtga accgctccat ccctatacaa aggcgctttt 1215661 gtcctcgatt ccgattccag atcctgaatt ggaggacaag cgtgagcgta ttctcttgaa 1215721 aggggagctg ccgagcccgg tcaatccgcc aagcggctgc gtgtttcgta cccgctgtcc 1215781 ggaggcgatg cctgaatgtg gagaatctcg tccccagctt caagaaatcg aacccggccg 1215841 ttttgtcgct tgccatttgt atcgaaatgc tgaaacgaag gaaaaagtaa gataaataaa 1215901 aagagtggct cctttttact agagccactc catttgttta tacttgatgt aaaaacttta 1215961 cacaaaccgg gtaagggaca gaaaccgttg atgggaggag tgtcaatcgg ccggtttctt 1216021 tgtctctttc aaacaagaca aggttgcctg tttcttcatt tgaagcaacg aggaaccctt 1216081 ccgttgggtc aaatacaaag tcacgaggcc agtttccttc tgtcgacact ctttctacga 1216141 aagccagctc tcctgaatat tgattcactt caaatacggc gatactgtca tggccgcggt 1216201 ttgcgacata aacaaaacgt ccgtcctgcg tgacatgtat tgcgcttccc tggctgttat 1216261 ctgtaaaatc atcagggatg gcagaaacga cttggatttc tctaaattcg ccggctgtcg 1216321 ggttgtattc aagcgcaatc acttcattgc ttaattctgt catgacataa gcgtattttt 1216381 ctttcggatg aaaagcgata tggcgaggtc ctgcaccggg agcgaaggaa tggcttccgg 1216441 attcagtcaa cacaccgtct ttaagcttat aggtgtagag cttatctata cctaaatcaa 1216501 ccgctaccac ataattgtgt tcaggtgtga accccgcgta gtgtgtatgc ggtttttctt 1216561 gtctttcgtg cggccctttt cctgtgtgag cggcctctga aacaggtgat tgcaagctgc 1216621 cgtcttcctg aaccggaaaa acgtgtacct tcccgctgtg ataattggca gtcagtacga 1216681 attgattttg atcatcaacg cttacgtggc atggcgaagg gccatcaatt aactgatgat 1216741 tcagaaatgt caattcgccg ctgtttttat cgatttgata ggcagcaact ccgccttggc 1216801 cgtctgcttt ttcgatggaa taaaggatgg tgttgttttt attcgtcgcc acatatgtcg 1216861 ggttgcccag cttagcggcc agctttggct cgctgagtgc ttttttctca gtatcaagct 1216921 caaatgaata aattccttcg cttccgcctt ttgtatatgt tcccacatat cctatgtatt 1216981 ttgtcatgcg atttccccct taaaaatgat gtcacctcta tattaacgta tcttgataaa 1217041 ataagctgtt caaaacatga aaaaggggaa gattcttcat tcgcctcgaa tcagcggcat 1217101 tgtgcagcac ctgaaggagc cgcctgattt aataatttct gacaggtcaa tttcgataat 1217161 gtgatagcct cttttcgata gctgttgatt gacatggcgg ttgccaggga gactgatgat 1217221 cgtttttttt ccgattgaaa ggacgttggt gccaagcgta aattgttcgt cctcgggcac 1217281 ctcaataaga tcataacgtt ttgccagcat atcggctgca tctggctcaa tggcctgtga 1217341 ataaattaac gcttcgcttt cagatataat gttaaatacg cagtccaaat gcaaaaattt 1217401 ttcatgaagc ttcactggaa cgatcgtata ttcaggaagt gcctcttcta gctggccgat 1217461 agctgaaatg tcggtgcgct ggctgattcc gacatagaca atgtcatcat cgataatgac 1217521 gtctccgcct tcaatactcg tatcaagcat gcgggtgtaa gagatacctt ggctgtgaaa 1217581 aaaatctttt ataacggctt cttctccttg gcgaatcggt tcagtcatgc ttgacagaaa 1217641 ggctttttct ccgatgacaa atcctatgtc cctagtaaaa acctgttctg ggagtccgtc 1217701 gcgaacgggc aaaaggacga cctcaacgtt gtgtgaccta agtgcctcca ctaagcggct 1217761 gtgctggtcg ttagcggttt ttacatgaat attgtcatct tcaaaatgtt tttgtgtttc 1217821 gtttataaca tcttttatgg tcatgtgctc aggtttgcat aagatcactt tttgaagtgt 1217881 gccgtattcc gttcggcata ccgttttgtg ctgagatttc gggatggata cgtccatttg 1217941 tttttcctcc taaagtgtga agaatacatt tattattccc tcatcatgaa aatcattaaa 1218001 ccattttaaa ttttagacaa atggaagaga atattgttta ataggagaat ataagtgcat 1218061 ttagctaaaa gatcagacat caaaggggag aaaggtatgg aaacaccgga aacaagattt 1218121 tgtaaagagt caaaggttgt gaaaaccagc agggtgttcc cgcttgacac gaacaaccat 1218181 aatacgctgt ttggcggaaa attaatgagc tacatagacg acattgcctc tatttcagcg 1218241 gcgcgccatt gcagacgtga aacggtaaca gcttcaatgg attctgtaga ttttttaaag 1218301 ccgatcgggc aaaaggattc tgtctgccta gagtcatatg tgacatgggt cggcacatct 1218361 tccatggaag tatttgtgaa agttattaag gagcatttga tgactggcga acgggaactc 1218421 gctgccacat cctttttgac atttgtcgca ttagattcaa atggcaagcc ggtgcctgta 1218481 ccgagggttg taccggaaac agaagaagaa atcatgctgc ataatacagc tgtacagcgt 1218541 gctaatgaac gtaagaaccg caagagacac agccaggcgc ttgcaaatgc gctcggaact 1218601 gataagcctt ggtgaacgtt aaacccaaaa cataagttgt tttgggtttt tttgtacttt 1218661 tcaatggtga ttattacaat ggttagtccg tttttgctag gggattctat aaaaaagcaa 1218721 caaatgtcat gttaaattga taattttgtg acaactttat taaagattca ttttagatat 1218781 atcttttatt cgtaagatca tgtattttaa agatatattt taaatacatc ttttcgaaag 1218841 gattgtttat aaaatgttag ataacaaaac aatcgaaatt attaaaagca ctgtacccgt 1218901 attgcaacag catggagaaa caatcactgg ccgtttttac gatcggatgt ttcaagacca 1218961 tccagagctt ttgaacattt ttaatcaaac aaaccaaaag aaaaaaacac agcgaactgc 1219021 actggcaaat gccgttattg cagctgcggc aaacattgac caattaggaa acatcattcc 1219081 ggttgtcaaa caaatcggcc acaagcaccg cagtatcgga attaagcctg agcactaccc 1219141 aatcgtcggt aaatatttgc tgattgcgat taaagatgta ttgggagacg ctgcaactcc 1219201 tgacattatg caggcatggg aaaaagcgta cggagtcatt gctgacgcgt tcatcggaat 1219261 tgaaaaagac atgtatgaac aggctgaaga gcaagccggc ggctggaagg agtataagcc 1219321 attcgttatc gcaaaaaaag agcgggaaag caaagaaatt acatccttct atttgaaacc 1219381 ggaagacagc aagccgttac ctgaattcca agcagggcaa tatatcagca tcaaagtgcg 1219441 gattcctgat tctgaatata cgcatatccg ccagtacagc ctgtctgata tgccgggaaa 1219501 agactattat cgaatttcag tgaagaaaga tggtgtcgtg tcttcctact tacacgatgg 1219561 gctgcaggag ggagattcaa tagagatcag cgcaccggca ggggactttg ttttagatca 1219621 tgcatcacaa aaagatctcg ttttgatcag tgccggagtt ggcattacac caatgatcag 1219681 catgctgaaa acatctgttt ccaaacagcc tgaacggcaa attctgttca ttcatgcggc 1219741 gaaaaacagt gaatatcatg cattgcgcca tgaagtagaa gaagcagcaa aacattctgc 1219801 tgttaaaaca gcatttgtgt atcgcgagcc gacagaggaa gaccgtgcag gtgatctgca 1219861 ttttcatgaa ggacagattg atcagcaatt cctcaaagaa ctgattgcca acacagatgc 1219921 ggattactat atttgcggtt caccgtcgtt tattacggca atgcataagc ttgtatcaga 1219981 gctcggatca gcgccggagt ctatccatta cgagctattc ggcccgcaat taagtttggc 1220041 gcagtccgtt tgaacacata catgaaactc ttctcctttc agagaagagt tttttattga 1220101 gatataagaa ggcagacaag cgccggtttc tacatccgga caatcacaga cccgctgcca 1220161 tttgtgcata cacggttttg ctgttcttgc attgttctca gcaattcatt gtttacctca 1220221 atcgctctaa ttagttgctt cattcttagc tccaaaccgg ccagcctgtc gattgtttgc 1220281 tgctggtagc cctcgggttg gggagccaat ggcagatcaa agggccaaag ggtattcgac 1220341 ttctgatttt tcatattgcg tattgcgcct ccaatcggtg tcactttcta ttatgttatg 1220401 ttcaggcgat atgcacgttc gcctagacac tgatgcatag agggcctgcc acggggcaca 1220461 ataggctcaa tatgaccagc ggatggaggt aaagatcggt gttatggatg gtatgggtat 1220521 ttttactgaa gccagttatc gtattttcga ttgcatatat tttgtttcgg cttgccggta 1220581 aaaaagctgt gtcacaaatg aacaattttg acctgctttt gaccttcgca atcggaacca 1220641 ttatcagtga gccgatcctt acatccaagc tgccgatgtc aatttattat gcgggtgctt 1220701 ttttggtgct ttatcttatc atgagcaagc tctctttatc taataaatgg cgatggctcc 1220761 tagtcgtgag cccgactgtc ctaatccgaa acggggatat tgatgaacgc ggccttcgta 1220821 aagaaaggct gactgttaat gagctgctcg gaaagctgag ggaaaagggc tatgccgacc 1220881 cggctgacat tgatcttgct atcattgaag aaacgggaga agtaagcgtc atcccgaaag 1220941 aggaagcgag agcggtgcag gtgcgggatt tgaatatgga agctgaacgg aattttatcc 1221001 cgattccgct catactggat ggcgaaatcc ttgatcataa tttgaaatat ctccaaaaaa 1221061 accgatcctg gctgtttgag aagcttgagg aaaaagggta cagccccaaa ctgctgtctt 1221121 cgattatcct tggcacgatg aatgcacgcg gtgatatatc ccttgattta aataccgcta 1221181 atgaaccgca gcatgatcct tacttatata aaccgggaaa taacaattaa gatggctctc 1221241 tcttgtaatg agagcttttt tcttttttaa agggaatttt tgtttggtgt caaatgtacc 1221301 tagttaggag gggaactgaa catgaaggac ttatccataa gaaacgacat ggcgccaacg 1221361 gtcagtttgc tgtattccgc agtggaagaa aacagtctcc gtctggcttc catcgtaagc 1221421 catatgacac acagtgaact ttactataag gggcgctgcc aaacaaaaaa cagcacggct 1221481 cagcttttgc accatatcac aaatgttgat atcagatggg tctggcgtat caaggaaaat 1221541 cggatcccgg accatattga acaggcatac ggcccgatga cagatgaaag cggacggctg 1221601 cctgaaccgg tgaatcagcc agacttagat gaactcctga aaagacatca gcatgtagta 1221661 gagaagctga aatcggtatg cttcacttta actgaaaatg ctttgaacca gccgctttcc 1221721 ttcgaaggtg acaccgcgac gatacgatgg ggaatttggc atatggcaga tcataaccgc 1221781 tatcatcagg cacatattga agctctcaaa aaagaatgga agcaggatgt ggcgaagtat 1221841 gaacgctaaa acgaagcttg tgactgatcg aattcgtttg cgctgtatgg aagatcggga 1221901 tcaagccact ttgtttgggc tgctttttaa tgatcctgac gtcatgacat attattccgg 1221961 tttaaaagat aagaggcaaa cccgcgagtg ggtcaattgg aaccaacgaa atgaaaaagg 1222021 gtacggcgtt agtctgtgga tcgccgaaga taagcggaca ggggagtttt tggggcaatg 1222081 cggcatcgtt ccccagcaga tcgaaaatca aaccgtaatg gaaattggct atatgtttgc 1222141 ccgccgccac tgggggaacg gctatgcgca agaagcggct cgggcctgtc tggactatgg 1222201 ctttaacgag cggcagttcg gcaaaatggc ggctttgatt gatccgggta acaaagcgtc 1222261 catacgggta gcggagaaaa tcggcatgca ttacagcaaa acgatcagaa aatggaataa 1222321 accgatcgcg gtatatgaaa gaaaatctta caattgaaag atagagctga gtttagtatc 1222381 atgatatcat gtaaagtttt ctagggttcc gcatgtcaat tgacatggac tggtccgaga 1222441 gaaaacacat acgcgtaaat agaagcgcgt atgcacacgg agggaaaaaa gcccgggaga 1222501 gtcaatctca tgtgagacga ctgtccgggg tttttttgtt ttcggagaat cttaatagat 1222561 agaaaggaat gactcaaaat gaaatgggga ttggtcgtgc ttgccgctgt tttcgaggtt 1222621 gtttgggtga taggcttaaa gcacgctgac tcagccttaa catggagcgg cactgccatc 1222681 ggcatcatat tcagctttta ccttctaatg aaggcgactc acagtctgcc tgttggtacc 1222741 gtgtatgccg tctttaccgg gctcggcaca gcgggaacag tacttagtga aatcgttctt 1222801 tttcatgaac cggttggatg gccgaagcta ttgttaattg gcgtgctctt aatcggtgta 1222861 atcgggttga agcttgtgac acaggatgag acagaggaaa aaggaggcga ggcataatgc 1222921 tgcactggat cagtttattg tgcgcgggct gtttagaaat ggccggcgtg gcccttatga 1222981 atcaatatgc gaaagaaaaa agcgtgaaat gggtgctgtt gatcattgtt ggttttgccg 1223041 cttcattttc cttgctgtcg tacgcaatgg aaaccactcc gatgggaacg gcttacgcgg 1223101 tctggacagg aattggcacc gccggcgggg cgcttatcgg catcctcttt tacaaggagc 1223161 agaaagacgc caaacggatc ttctttatcg cgttgatttt atgctcagca gttggtttaa 1223221 aaattctgtc ataaattgat ttttatcaaa tcttcagtat aatggataaa tagtttagac 1223281 ttacaaagat aagagggatt attcatgaaa tcatatatga ctcagcggtt ggacgaatac 1223341 cgtgacggaa atgaggataa aggtcggctc ttggtcagct gccccgatca gccgggtatc 1223401 gtctctgcag tttccgcgtt tttatttgaa cacggtgcca atattataga atcaaatcaa 1223461 tatacgacag accctgaagg cggccggttc ttcctgagaa tcgaattcga ctgcgcaggc 1223521 attcgtgaaa aaaaatcatc acttcaggca gcgtttgcct ctgttgcgga aaaattcgac 1223581 atgacatgga gcttaacttt ggcgagcgaa ctgaagcgtg tcgccatttt cgtttcaaag 1223641 gagctccact gcctgcatga gctgatttgg gaatggcaaa ccggcaacct gatggcggag 1223701 atcgctgttg tcatcagtaa ccatgaggaa gcgagagagc tggttgagcg cctgaacatt 1223761 ccattccact atatgaaagc gaacaaagac atcagagcgg aagtcgaaaa gaagcagctt 1223821 gaactgctgg agcagtacga tgttgatgtg atcgtgctcg cacgctatat gcagattcta 1223881 actcctgatt ttgtttcggc tcatccgaat cgcatcatca atatccacca ttcattcctg 1223941 ccagctttta tcggtgcgaa tccgtacaaa cgggcctacg agcgcggcgt gaaactgatc 1224001 ggtgcgacat ctcattatgt gacaaacgat cttgatgaag ggccgatcat tgaacaggat 1224061 attgagcgtg tggaccaccg cgataatgcg gaagcgctga aaaacatcgg aagaacaatt 1224121 gagcgcagcg tgcttgcccg tgctgtgaaa tggcatttgg aagaccgtgt catcgttcat 1224181 gaaaataaaa caatcgtctt taactagact gcaagaggcc cgcgcaatgc gggctatttt 1224241 tgatgacaaa aaaccttgac aagtgtcttt tttctttgca taatataaaa aaatcattga 1224301 gcgttgaaga ggattagtaa gcagaccttt ctgtgacaga gagcaaaatg aatcgctgaa 1224361 acattttgcc gcatgaaacc tgccgaacct gccttggagt cctaggggga aaacctaggc 1224421 gcataacctg gcgttacagg agagcggagc gtgcacaagc gcgttcaatc aaggtggtac 1224481 cacggaaacc catttcgtcc ttatgaatca ggatgaaatg ggttttttta ttgtagaaga 1224541 gccgcggagg agaataaatg aaaaaacaaa gaatagtagt gaaaatagga agcagttcgc 1224601 tcacgaatag caaaggaagc attgatgagg caaaaatcag agagcatgtt caggcgattt 1224661 ccgtgttaaa aaaagcgggg catgaaatga ttctgattac ctcgggtgcc gtagcggcgg 1224721 ggttttccag cctcggttat ccatcccgtc ccgttaccat caaaggaaaa caggcggcgg 1224781 ccgcggtcgg acaaacactg ttaatgcagc aatatatgaa tcaatttaaa caatactcac 1224841 tgactccggg acaaatcctt ttaacgagaa atgatttttc gaaaagagaa cggtatcgaa 1224901 acgcgtatgc tacgataatg gaattattag agcggggcgt cattccgatt atcaacgaga 1224961 acgattctac atctgttgaa gaattgacat tcggagataa tgatatgctt tctgcgttag 1225021 tcagcggatt gattcacgcg gaccagctca tgattctcac tgacattaac ggactgtatg 1225081 atgccaatcc aaatgaaaat cctgaggcga aacgatttga ttatttgcca gagatcacgc 1225141 ctgaattgct tggatatgca ggttcagctg gatcaaaggt cggcaccggc ggaatgaaat 1225201 caaagctgtt agccacacaa accgcgctgt ctctgggagt gaaagtattc attggaactg 1225261 gcagcggaga gcaaaaactt gcggacattt tggacggcag gggagacggc acttatatcg 1225321 gagacaaaga actatcttcg gttaacaaca caaggcagtg gattcagttc cactcgccga 1225381 tatcgggaga aattatcatt gatgcgggtg ccgaagaggc gatgatccat aatggaagca 1225441 gccttttgcc cgctggagtt gtgggcgtga acggaagctt tccgaaaggg gcggttgtgg 1225501 aagtcagggg accgggcggc gtgatcggca aaggccaaac tcattactcc tccgaggaga 1225561 ttatggaggc taaaggcaaa cgcagtgacg aacttgattt tgagaaaacg tttgaggtta 1225621 ttcataggaa tgactgggtc aatgtaaaag actaggaggc ggaaaaatga gtgaagtttc 1225681 tgtaaaagcg aagctggcga aagaagcagc agccgaaatg atcatgaaaa caacagccga 1225741 gaaggatgag gcgctcagcc tcattgcaaa cggactccgc aaagaactgg attttctctt 1225801 ggcggagaat gcaaaagaca ttgtgaacgg aaaagagaat ggtttaacac cggacatcat 1225861 tgaccgtctc tcattggatg agaaacggat acgcgatatc gcggacgcgg tggagctctt 1225921 aatcgactta gcggacccaa tcggcgactc tcttgaaacg attgaaaaag aaaacggcct 1225981 gtttattgaa aaaatccgtg tgccgctcgg tgtcgtagga atgatttatg aggcgaggcc 1226041 aaacgtcaca gttgatgcgg ctaccctttg cctgaagaca gggaacgcgg ttgtgctgcg 1226101 gggaagctcc tcagccatcc acagcaacaa agcgctcgtc agtgtcattt acagagcact 1226161 tgagcaatca gcgcttccga ttcacgctgt gcagctgatt gaggatacga gcagagagac 1226221 agcaaaagag ctctttacgt taaatgatgg cttagacgta ttgattccgc gcggaggcaa 1226281 gaaactgatt gatctcgttg tgagagaatc aacagttcct gtattagaaa cgggagcagg 1226341 aaactgccac atattcattg acgaaacagc caaaccgcaa atggcagaaa aggttgttgt 1226401 aaatgccaaa acgcagcgcc cttctgtatg caacgcgatt gaatcattgc tgattcacaa 1226461 ggcttgggca agacagcacg gaaaagaatt gctggaccag ctggaaaacg cgggagttga 1226521 aattcgcggt gatgaattgg tatgtgaact tcatccttca agcaaacaag catcaaaaga 1226581 agattgggaa accgaatttt tagcgcctgt cctcagcgta aagacggttg aaaacgtcca 1226641 agaagctgta aagcatatcc aacaatacgg caccaatcat tctgaagcga ttttaactga 1226701 aaatgacaaa aatgcggtat attttcaaac ggctgtcgat gctgccgctg tctatcataa 1226761 cgcgtcaacc cgctttaccg acggctttga attcggctac ggagccgaaa tcggcatcag 1226821 cacgcaaaag cttcatgcaa gaggaccgat ggggcttcct gcactgactt ctacaaaata 1226881 catcattaaa ggaactgggc aaatccgtga atagcggggt aatgttcaat gaaaaagctt 1226941 atctcattac gagataagct tttttatacg cgaaaaattg acatttcaaa tttaattgtg 1227001 tacaatttaa ttgtataaaa tatattgggg gaatgaaaaa tgagtcagcc attatttacc 1227061 gcaactgttt cagcggtagg aggaagagaa ggaaaggtca tttcatcaga ccgcgttctt 1227121 gagcttgatg tcgcaatgcc ggggacaccg agagccaaga aattagaaaa agcgacaaat 1227181 ccagagcagc tgtttgcagc aggttatgca gcttgctttg acagcgccct gcagcttgtc 1227241 gcaagaacag aacgggtaaa agtagagaca gaggttacag caaatgttag cctgttaaag 1227301 gatgaagcgg accagggcta taagctgggt gtgacgctgc aagtaaaagg agaaggagtc 1227361 agtgcatcag aattggaggc gcttgtgaaa aaagcgcacg gcgtctgccc gtactcaaaa 1227421 gcaacctccg gaaatattga tgtgacactt gaagttgctg aataaataaa aagaggatgc 1227481 ctgtacaagg catcctcaat ttttttgatg aagtgtttcc agtaatgtat atagagcgga 1227541 ctttaactgt ttgagatcct ccccagactg ctttgagagc cccagaattg tccctggaat 1227601 gtcaaccgct ttttctttta ataacgctcc gtcctctgtc aggctgatca acacggaccg 1227661 ctcatcctct tcagatcttt ttctcgtaat caaaccctgt tgttccattc gtttaagcat 1227721 cggagtgagc gttcctgaat ctaaatacag ctgttcgccc atttttttga cagtaagcgt 1227781 ttcatgttcc cataacaaaa gcaaagccaa atattgaggg tatgttatat tcagcttatc 1227841 aagcagcggc ttgtattgct ttgtcatctc ccgcgaactc gcatatagca aaaaacaaag 1227901 ctgattctcc aatttcatat gatcaaattt attttccatt ttgttcacca actctttttt 1227961 gtcattcgat tctattgtat ctgaaaaacc tcacttttcc tattctcggc aaacatagca 1228021 tgtttaaaaa gatcagaaag ggaaatataa caactagata caaataagga ggttgggaaa 1228081 tatggcacta tttacagcaa aagtaaccgc gcgaggcgga cgagcaggac atattacatc 1228141 agatgacggt gttcttgatt ttgatattgt catgccaaat gccaaaaaag aaggacaaac 1228201 cggcacaaat ccggaacagc tctttgcggc agggtatgct gcatgcttcg gcggcgcgct 1228261 cgaacacgta gccaaagagc agaatatcga aattgattcg gagattgaag ggcaggtcag 1228321 cctcatgaag gatgagagcg acggcgggtt taaaatcggt gtcacacttg ttgtgaacac 1228381 gaaagattta gatcgggaaa aggcacaaga gcttgtcaac gccgctcatg aattctgtcc 1228441 ttactcaaag gcaaccagag gaaatgttga tgtaaaacta gaattaaaat aatgaccggc 1228501 atcctgagga ttctcaggat gttttttggt gtcggacatg cggggcgggc acagatttat 1228561 gataaaactt cagagaagcg tttgaagcat gcctttaaac caaaagttac agatgaagcg 1228621 ggtggctggc acggtgtctg ccgtgctgaa ttgcgcgtat atgctgtttt gtatttgcac 1228681 agggcatagc ggctacttgg agaaataaca aggaccaggc cgcgcatgcc tgatcctttt 1228741 aatattcttt cttattggcg aagttccgcc atgcttgaaa cggggataaa tgctctgtta 1228801 gtgtcacttg ataaaagggg atcgttcttt cttcagcagg tttatcaatt tctttataaa 1228861 tgaatgaatc atcaaacccg gcttcggcag cgtctgtgtg ctcagctgca tagaaaacgg 1228921 ctttaggccg ggcccagtag atggcgccca agcacattgg gcatggttca cagctcgtat 1228981 acaaaatgca gtcatcaagc tggtaggctc ctagcacctt acaggctttc cgaatagctg 1229041 tgacttccgc gtgggcagtc ggatcattgc ttgttgtgac gttgttctgt ccctctgcaa 1229101 taatggctcc gtctttcacg ataacggctc caaaaggccc gccgattcct gcattcactc 1229161 cttcacatgc gagagtgaca gcccgtttta agaacgtttc atgattcatc ccaatccctc 1229221 ctgtcaatag agtgttatta gtatagccga aaagaatgca aagaacattc ttaaaaaagt 1229281 gcaaaataaa caaagtattt gggggatttg ctaaataaga aaccgattgt ggctgtatta 1229341 tagaaaaaaa ccatctgcca aatgcagatg gttttttcaa attatactag ctgtgtctgc 1229401 tgtgctcttg cctgttttgc ggcttcaacc atatttttca atgctgcaac cgtttcttcc 1229461 tgctgtcttg ttttcaatcc gcagtctgga tttacccaga agcggtcagt cggacagacg 1229521 gcaagcgcat caacgataat attgtacatt tcttcagttg acggcacacg agggctgtga 1229581 atgtcatata caccaaggcc aagccctttc aaatacgggt ggttttttaa gtaatctaaa 1229641 aatcctccgt ggcttctgct atgttcgatt gtaatcacat cggcatcaag atcattgatt 1229701 gtatcaacga tatcttcgaa gttgctgtag cacatatgtg tatgaatttg tgtctcgttt 1229761 ttcacggaag aagtggttaa tctgaaagct tctgccgccc aagtcaaata ctcatcccaa 1229821 tcgcgggttt tcaatggaag gccttcacgc agcgctggtt catcgacttg aatgatttga 1229881 atgcctgcgt cttcaagcgc tttaacttct ttgcgaaggg caagcccgat ttggaaggcg 1229941 atttctttcc tcgagatgtc gtttcgaggg aaagaccagt ttaagattgt aaccgggccc 1230001 gtcagcattc ctttcacatg cttggaagtc aatgactgtg cgtagactgt gtctttcact 1230061 gtcatcggtt caataaattc aacatctccg taaatgactg gcgggcggac acagcgtgag 1230121 ccgtatgatt gaacccaggc atatttagtg aaggcgaaac cggccagctt ttcaccgaag 1230181 tattcgacca tgtctgtccg ttcaaattcg ccgtgaacaa ggacatcaag ctccaattct 1230241 tcctgaatat caatccatct ttttgtttcc gcattgataa agttttgata ctgttcatcg 1230301 gaccactcag ctttccgcca tttttggcgt gcgctccgca cttcagcaga ctgcgggaag 1230361 ctgccgatcg ttgtcgtcgg caaaagcgga aggccgagag attcattttg tagggctaaa 1230421 cgttcttcaa acggaatcgg gcgcttgaag tctttatcag ttaattgctc aagctctttc 1230481 ttttgttcag aattggcgcc tgttgcaaac tgtttaagcg cctggatatc agccttagcc 1230541 tgctgaatct cttcgctgat cgccgctttt cctgatacta agccttcttt caaagctgtc 1230601 agctcggcca gcttttcttt tgcgtaggat aatccgttca ataggtcttt ttccaaatgc 1230661 tcatcagggt gtttcgctac tggaacatgc agcaggctgc tggaaggctg aatccacagt 1230721 tcatcaactt ttgcaatgct gagaatatca agaacggcat cgagacgctc ttcaaggtcc 1230781 gctttccaaa tgttgcgtcc gtcgataacg ccggctgcca gcactttatc tgtcgggaag 1230841 ccatgtgttt taagctgttc caggtttctg cctttgtcgt gaacgaaatc aaggccaatt 1230901 ccctgaaccg ggtaagagat cagctcttca taagcatcaa cagaatcaaa atacgtctgc 1230961 aaaagcacat tcaaggatga aagctcactt gtaatgcttt caaataattc ttttgcgccg 1231021 cgtacatctt cactagaggc ggtaacgagc gccggctcat cgatttgaac ccattttacg 1231081 ccttcttctt caagctcttt caaaagctgt acatataatg gcacaaggcg tttttggatc 1231141 gcttttgctt cagacggttc atagccttta gcaagcgtaa cgaacgtata agggccgaca 1231201 atcacaggct ttgtttccac accgtattcc tgtttgatcc ggcgataatc ttcgagttgt 1231261 ttgtttcttg tcagacggaa ctcaatgctc tcgtcatatt ccggaacgat gtaatggtaa 1231321 tttgtattaa accattttgt catttcacta gatacagcgt ctttgattcc gcgggcgata 1231381 gcgaagtatg tatcggtagc gtcagtcaaa tgtctgaacc gtttcgggat ccagttgaag 1231441 ctgactgctg tgtcgagtac atggtcatac tgtgtgaaat cagaaacagg cacaacatca 1231501 atctgctggt caatttgtgt ttttactgcg gataaaaata gttcgtcgat ttgcttcaaa 1231561 aacgtatctt tatcagtact gcctttccaa tacgcttcaa gtgctttttt ccattcccgg 1231621 ttcagtccga ttctcggaaa tcctaaattc gatgttttga tggttgtcat tgtttctcct 1231681 cctttatatg taaaacactc tctttcaccc gcggatacag gctgctaaga ggttttctca 1231741 caacaaaaag cctctttccc atgagagaaa gaggcttttc tacgtaaaac actgcctctc 1231801 tcatctctca gacacaatct gatggaatta gcaccgtgcc ttatgagaca tcagtctcgg 1231861 cgcgaaaagc agtgcgcccc atttcacaat ggtattacgg tcggttgctg ttggggtcaa 1231921 aaggccaatc cctcgcccaa ctctcgataa gagaaaatgt tattaatttt ttgaaaagtt 1231981 gaatcatttg ttggtaatct taacagtaat tcaaattcat tgtcaacata gaatttgaaa 1232041 tttttattta catgatgtgg tgtatattat ataagaaaaa taatcttata gggtcaacaa 1232101 atgtgattgc tctgcttttt ctgcgagctc atcaggagct gttaaataca ggaatccatt 1232161 gcctgccagc gtttttgcaa tatcaagagg aagtgtcctg cggattagct gtgcgaaaac 1232221 ctcagattca gaaagctttc tttgaaatga ttcttcttca tagcttttga ttaaagcaag 1232281 cgcaccgctg acatgagggg cagccattga agtgccggtc agcttaccgt acttcttgtt 1232341 gggaagggtg gataagatgt tttctcctgg tgccacaagg tcaatctctt tattcgcgtt 1232401 agaaaattct gataattctc gcgctacaga aacagatcca actgcaatca cttcattata 1232461 agctgcgggg taggaaagct cttctgtgcg ttcgtcgccg tcaccttcat ttcccgctgc 1232521 acaaacgaca agcactccgt ttttcactgc gtttttcact gcttctttta gctctggcac 1232581 atcgcttggc cctccaaggg acattgagat gatgtcgact ttctgttcca ccgcgtagtt 1232641 gatgccgtta attatccatt cgtattgtcc gctgccgttc tcgccgccaa gaaccttcac 1232701 aatcaatagg cttgcctcag gcgcgactcc ggcaatgcct ccgtttgaat cattagctgc 1232761 aattgttccg gcgacgtgtg tgccgtgtcc gttgtagtcg gaaatcgcat cttccttgcc 1232821 gccgtcgtca tccgtgaagt tctttccgcc gatgatttga ttttttaaat cagggtggct 1232881 tgtgtcgcag cctgtgtcta atacagcaac tttaatattt ttgcctttta ccccttttgc 1232941 ccacatttct ggcgccttaa tcactttaat gccctcagga agctcgttta catccatgat 1233001 ctgctcattc gtcacatacg ggatcaagcg gatttcacca ttcataaaaa agccctcctt 1233061 ttttatgctt gcaagtggat tcaagggtgt tgcctcatat tatatgaaaa aagcaagcgc 1233121 tcggacagag ccatttgaag cattttgaaa aaataggata cacaccaaag aattagtaat 1233181 cttcaaaata ttggatggct tcaacatgta tgactgggat tcaactgtaa gtcaagttat 1233241 aatagtgttg gggaaaggag cagtgtcatg aaactgaatg aaaaattata tgcatttttt 1233301 tcagagcatg tggaacaaat ggccgaggaa tggattgaaa cgatggagga aagtgatccg 1233361 aattcgcttt acgccctaca taatgcaaca gtaacggaag aattgaaaga gcaggacaga 1233421 gaattttacc ggcatctgaa ttacatgtat gttttaccgg aaaaacaatt tctcgaagag 1233481 tttcaagagt gggtcattga gctgaccaac gatcaaaaac atctcgacac accggttcag 1233541 tatgtcattc gggagtttat gagaaacagg agattatata cgaagtattt tgagaagttc 1233601 gcagaagaaa atgaatcagc gtttgaaccg ggagagaagc aaaaatgggc agatttgatt 1233661 gtaaaagtat ttgatttcac catttataca ttcgttgatc acgctgaaat gaatgccaag 1233721 cagcaattaa acgcccaaag agaaatgata ttggaattaa gctcacctgt cattaccctg 1233781 agcaaatcaa cagctctgct gccgcttgtc ggtgacattg ataccgaacg ggcgaagttt 1233841 attctggaaa acacgcttca agcttgtgcg aaaagacgtg tggagcatct gttaatcgat 1233901 ctgtcaggtg ttgttgtggt ggatacgatg gtggcgcacc agatctttaa attgattgag 1233961 gcgcttaatc tgatcggtgt ccggtcaacc ctgtcaggaa tcaggcctga aattgcgcaa 1234021 actgctgtac agctggggat tgacttttcg aatattacta ttaaaaccaa ccttgcccaa 1234081 gcattaaact atcatcaata aaaaaatccg ctatctgtga tagcggattt tttatgatgc 1234141 gaaacataaa gatacgagaa aggatcccgc gaataataag aggacgaggc aaaagaacac 1234201 ccagtcgcgc cggttcacgc tcaatgtcct gtagtatgtc cggtttctgc ttcctgtaaa 1234261 tcctttcgat tccatcgcaa gcgctgtccg ttccgctttt ctgatggcgc ttgccaatag 1234321 cggtatggta tatcgtttta acgcactgat tttattaatg atgccgctct ccgccgctcc 1234381 tcctctgatt ttatgagcct gctgaatcag ctggacctca tcctttaaca gcggaagaaa 1234441 gcgaaagcct gcaatgacac cgtacgcgag ctttggtgag agcctgcact gctggacaag 1234501 gctcagcata aatagaatcg gatcggttgt aaaaacaaac atcatcgata aggcggaaaa 1234561 gcataaaata cgaaacccga gagagatgcc gacagacaca ttatcgctgt taatggagat 1234621 agggcctgct tgaaacaaaa aattatccgg tgttgtcggc acttttccaa aaactgcggc 1234681 tgtccacacg catccgaatg ctaaaatcaa aaacggaatc gtaaacaaca accatttttt 1234741 caatgggatt ccggccgcca gtaaaacgcc cgcaacgatg atgatataaa aacatgccgg 1234801 agtgtaaggg ttgtaaataa acgacagcat gacgacacaa caaaaaaccg ccgccgcttt 1234861 cacagtcgga ttaatgagat gtaacggttg cttcatcacg cacctcctct tgaaatgcca 1234921 tccattcata tagaagggga agggtgagct ttgctttttg aacaagccct gtttcttgag 1234981 aaaacaactg cgctggagat ccgtcaaagg ccaggcctgt atcgtgaagc acaagcacgc 1235041 tgtcagcata cgaagagact agctccatat cgtgtgtaat cataaggaca gcagttccct 1235101 ctgccttgat acgttgaatc atttccatgc attcagccgc cgtgcgggca tcctggccaa 1235161 aggttggttc gtctaataat aaaaccttta cgtcatgcat gagcatagta gctacgctca 1235221 gtcgccgttt ttgcccttgg ctgatcgcaa acggatgatg atcagccaaa tgcgcaagac 1235281 caaaacgctg cagcaggtgt tgcgcttttt tctcagtttc agcatttgct ttctggccga 1235341 acagaagctc gtcatacacc gtatcggtga cgaattgatg ctcagggttt tgaaaaacaa 1235401 atcccatccg tttacgcaat tctttttctt tatatttctg cagcggctga tcatagagaa 1235461 ggattttgcc gctttgcggt ttcatgagac tggccagaac tgataggagc gtcgattttc 1235521 cagttccgtt cggaccgaca agcgccgtta aagagccttc gcgcaacgaa aagctgatgt 1235581 ctttgaaaat cgcctgctgt cctctcgcga acgaaaggct gctgacttca agcacactct 1235641 ccccagaagg ggctttcttc tttttgacat gcccggcagg aataggctct ttgaacagca 1235701 tctcttttga taaagtaaac ggcatactca gcttttcctg cagatgacag acctttggaa 1235761 tggcgatgcc caatttcttt agtgtctccg cttcatgctg aaatagattt ttcgtcaggc 1235821 catccagtgc ctttttgcct gatttgtcga gtacgatcgt tctctcaatc caaggcgccc 1235881 attcatcaag ctggtgctca atgacgagga ggctgaaacc tttttcccgc tgaagatcct 1235941 tcatcagatg aacgaactcc cgagctgaga aagggtctaa aagagaggtc ggctcatcta 1236001 aaataataag ctcaggctcc atcgccaaaa tacaggcgag agccactttc tgcttttgtc 1236061 ctcctgaaag ggttgagatc attttttctt ttaaatgggt aatgcgtaat ttttctaata 1236121 cggcgttgat tttctctgtc atttcttctt ttggaatttg cagattttcc agcccgaacg 1236181 ctatttcgtc ctccaccgtc agcatgcaga actgctgatc aggatcctga aaaacgaccc 1236241 cggcatgctg agtaatcgtt tcggaggttt cagcatctgt gaccggcttt tgaaatagaa 1236301 atacatgtcc ggactgaatg ccgtcgcaag cctccggata tagaccgttt aaacaaaggg 1236361 cgagcgagct tttaccgcat ccgctcggtc ctaataataa aacacattct cctttttgaa 1236421 gctcaaacga aatgtcttga aaaaccggtt tctcgtcttc ttcataagag aagctgagct 1236481 gctcaaccgt cagaagctca tcaaaggctt gcatgttctg acgcccgctt ccgtttcttt 1236541 ttcagttcct ttccgagtgc cattccgttt aacacacctg tataagcgag agagtcgctg 1236601 acagcttttc cgagaagccc cgccaaaagc gcgccggaaa tgaggcggat cacaagcata 1236661 atgagcagat aacctggtga ataggctgca tagccagaaa caaagagatc atagataaag 1236721 ctggctactg aagaccccat accggccagc ataaggacag ggagagagta tgctttccag 1236781 cgtgttgcaa gaaatacagc ctcagccccg agcccttgaa caatgccaat gacgatgacc 1236841 atcgggccag acggatttcc cagcaggcac tcaacgagag cggcaatgat ttcagaaacg 1236901 agcgccgcac ccggttttcg aatcatgtac gcggcgatca cagaaacgat aaaccaaatg 1236961 ccgtaaattg gttcataggc gattggccca aacatacctg caagtacgtt tccgaaatgt 1237021 gtaaataata aataaacaac ggcaaatacg atactgataa cggacatgat gacaatttct 1237081 tttactttcc agcttttcat gttatccctg ctttctgttt tttcttgatg gactgttagc 1237141 cgaaagattc acagtcatgg tgatgtggtt tgtttgctgc tcagccatgc ggaaaacggc 1237201 ctccaatgtg ctgaatacgt catgcgcatc cccgtcaagc tcgctcgcgt aatggacacc 1237261 ctgtacgaaa gtgccttggg cttttgcaat gtcgacagcc tccataatca atcccatata 1237321 atccggctca ttcattggat aaagggcaaa ttggcacggc gcttccgcct tcaagcctcg 1237381 gacagcatct tcattgacac gcttatcacc tttggaaaga tatgtatccc cctgtgtgtc 1237441 acccgggcat ccaatggaaa acgtgccgtt catgacgatg tgttgttcgc tgtttgctgc 1237501 atgaaggtaa atggcttttg cagcatcgaa tacatgatca atcgatccgc gtaacaccgt 1237561 gctgatatgg tcggttttcg tccaaacctt ggatgtatct gtttttttca gcgcagactt 1237621 gatcacactg ataaaatcat ccgtcatcgg atataaagag aagcgaaaac cggcgattct 1237681 gcttgtaccg caaatatgct ccatttctcc gacctcctgt ttttttggta aaataaaaaa 1237741 ctgcatatcc taagggaata tgcagtcata gatcgattaa gcgcacaaaa aaatacacca 1237801 ttcggtcaac ctgcacttcc ccacgctggt attatccaga tcgggtcata agggatcaaa 1237861 gcgcgtttct tccgcgcttt atctcagcca aaacagcacc cctagtgctt tccgtataca 1237921 attttttatt ttgacatcat aatagatgat aagaatcatt ttgtaaacaa cgaaatcatt 1237981 tttttcatat agggacggga gaggatggtc aaatttggaa aaaggacaca tattaattgt 1238041 ggaagatgaa gaaaaaatcg ccagggttct tcagcttgaa ttggaatatg aaggatacag 1238101 cgtcacgatc aaacacaatg gcacagaagg tcttgatgcg gcagcggaag gcgggtattc 1238161 cttggtgctt cttgatgtca tgcttccggg gcttagcgga ctggaagtgc tgcgccgctt 1238221 gagaaaaacg gattcgcaga caccggtcat attattaacg gcgcgagaca gtattcctga 1238281 taaggtaaca ggtctggaca tcggtgcaaa tgactatgtc accaagccgt ttgaaatcga 1238341 ggaattgctt gcgagaatca gggcggcgct gcggcaaaat ggaacaaaaa ctgaagatat 1238401 cggcaccttt cttacatatg acgatttgcg ggtgaacgaa aaaacccgtg aagtgagacg 1238461 cggagacaaa gaggtggaat taacgccgcg ggaatttgat ctgctcgtct atatgctaaa 1238521 gcatccgcag caagtgctga cacgggagca aattctaagc tcagtatggg gatttgatta 1238581 tatcggtgat acaaatgtcg tggacgtcta cataagatac atcagaaaaa aactggacta 1238641 tccttacgaa aaacagctga tccatacgat tcgcggggtc ggctatgcca ttaaggggta 1238701 aacgatgaag ctgaagacca agattcatct atacacttcg atatcactgt tgattttatt 1238761 aattttggtt cataccgcag tatatctcat tttttcgtct gcgctgacat caaaggatgc 1238821 ggcccggctt gctgatgaga cggataacat tgccgaagcg ctgcgtgccg ctgaaacaga 1238881 aggagtggct ttgcaggata tgctgcaggc ctatcttccg gcaaatggca tggtgcgtgt 1238941 agtgaatggt gatcaaaaag ccgttatgac gatcacaaaa gaaaaagcct ataaagattt 1239001 tcctctctct tttcatagcg gcgaaacggc agatgtgagg aaacctgacg gcaagctgtt 1239061 tgccgaggct gctgttccgg tgatttggac cgatggacaa gtcgtgtctc ttcagctggt 1239121 tgaaagactg gagaacacag aagagagtct gtttctgctg aaaatcatct taatcgctgc 1239181 aagtgctgct gtctgcattg cttctttttt tgcaggcagc ttgctagccc gccgaatcat 1239241 caatccgatc agacgattaa tgatcacaat gaaagacata cagcgagaca aagaatttaa 1239301 aacgatttct ttagaaggac agtccaacga tgaattgtat caaatggggc tgacatttaa 1239361 tgaaatggca atgatgctga aggagcacta tgataaacag cagcaatttg ttcaagatgc 1239421 ttcacacgaa ttgaaaaccc cgctcactat tatagaaagc tacagcagcc tgatgaagcg 1239481 gtggggtgca aaaaagccgg aggtgcttga ggagtcgata gaagccattc actcagaagc 1239541 ggtgcatatg aaaaaactga ccaatcagct tttggcgctg gccaaaagcc atcaaggact 1239601 cgaggttgat ctgaaaacaa tcgatctgat taaagcggcg cgcgcggtta tgcaaacgct 1239661 ccagtccgtt tatcagcgtg acatattgct tgaaacagat aaagagagcc tgcttgtaaa 1239721 ggcagatgaa gaacgcatca agcagctgtt gaccattttg cttgataatg caataaagta 1239781 tagtgaaaag cctattgaga tgtcagccgg aacgaggaat ggacggccat ttctatcagt 1239841 gagggatgaa ggcatcggaa tacctgagga gcatatcccg catttgttcg aacggttcta 1239901 ccgggcagat gaggcacgaa acagaaaaac aggcggaaca ggtttaggcc tttccattgc 1239961 caagcaaatc gctgatgagc atggcattga gctgtctgtc aaaagcaagc cgggacaagg 1240021 aacagctgtc accatgcaat tcagcgaaca gaatggggga ggccgatgac taaaacaata 1240081 aaaacagtat cttttgctgc agcagccatt ttagttgtca tcatctgtac gtttctcatc 1240141 attcggcaaa cccatgagaa cgtattgtca aaggagactg tcgtaaaaaa agtcgaagcc 1240201 tcttatgaag gcaaggtcac gaaagcaaca caatcaaagg ataaaaaaac atatgatata 1240261 acccttgaaa atccaaaggg aacttacttt gtaaaagcag acgcaatatc ggctgacatt 1240321 ctttcaatga atagagtaaa agcagtgaat ccatctgcca tgacagaaaa agaagccgag 1240381 catctcgcgc ttgagcgggt gccgggaacg gtcaaaaaac aaacacggca aagtcaagtt 1240441 gccacttata ccatacaaaa agaagacggg aaaacatacg aagtgaaggt agacatgcag 1240501 gcaaaaacag tcttgtctgc cgatcaaatc agcagcaaag atcaacaaaa aacgccgatt 1240561 acgaaaaaag aagccaaaac aattgcagag cgaaaaacgg gcggaacagc ggatgacgca 1240621 gatctcgaag aaagtgaggg cactctcatc tttgaagtag acgttgatct tcctgataat 1240681 aaggaagcga cagtgaaaat caatgcctac acaggaaagg tagctaacat tgtgtatgaa 1240741 gactgacggt ttctcatcaa attctcatct tgctctcgtt ttcctttcat gttgagtatg 1240801 taaactgtac tcatacaaaa caaaggaggg ctcacaaatg ctcaagaaaa aatggatggt 1240861 cggtctttta gcagggtgcc tagcggccgg aggattcagc tacaacgcgt ttgccacaga 1240921 aaacaatgaa aacagacagg cttcttctaa gacggatgca ctcactgaac aagaagcaga 1240981 agcaattgct aaaacagttg ttgacggcac agtagaagac attgacagag acctttacaa 1241041 cggcaaagaa gtctatgaag tggagattga aaaagaaggt gaagactacg acgtttatgt 1241101 agatattcat acaaaacaag cgcttaatga cccgttaaag gagaaagcag aacaagtcgc 1241161 cataaccaaa gaagaagctg aagaaattgc tttaaagcaa acaggtggaa ccgtaacaga 1241221 aagtaagctt gacgaagatg acggtgctta catctatgaa atggaaatcc aaacgaagca 1241281 aggaactgag acagaatttg aaatttccgc aaaagatgga cgcattatca aacaggagat 1241341 agatgactaa tcaaaacccc cgctgcagcg ggggtttttc atgataagaa accttctttt 1241401 ggacaatcta agtagaaaag gaggcgaaac gcatggaaaa gaaagaggag caatacatca 1241461 atcaggctga atatgtccct catccgacga aggaaggaga gtatgcctta tttcttcatg 1241521 aaacgtatca tttgctttct gaagatgacg agacacaaac aacagaataa gggcttaggc 1241581 ccttgttttg ttccgtaatt gtgatgtaag cgcatttatt acttttttga gttgacatag 1241641 cttgtttttt tctgtaatct cagtgtgtca attcaattag gaacttcgtt aggtgaggct 1241701 cctgtatgga gatacgctgc tgcccaaaaa tgtccaaaga cgccaatggg tcaacagaaa 1241761 tcatcgacat aaggtgattt ttaatgcagc tggatgcttg tcctatgcca tacagtgcta 1241821 aagctctacg attgaaggcg cccgcacgct ttttttgccg tgcttctttc accttcaatc 1241881 ccgaaggctt tttttatgcc tttaaaacga aaccaatcaa aggaggtgcg gagtatggat 1241941 tctccccatt cgagtcaatc tgaagaagta cccatatact atgacagcaa gacaattgat 1242001 tacacgatga ggagacgaac tgccgcacct tctggcgagg ccggcacgtc tccgtagagg 1242061 aggtacgagt cccgatggtt caaaacatga cctatgacga actcatttta cgcatcatta 1242121 ttttactgcg agacgggaaa atcagggatt ttagaagtgt tattgatgag cttcagccct 1242181 atgacatggc atttattttt aaagaaatgc cggaaaaaca tcgcgcccgc tatttatctt 1242241 atttaactgt agacgatatc actgatatga tcggggagct ggaacgcgaa tttcagcttg 1242301 tcgtcttaaa taaagtcgga aaaacaaaag caacactggc gatgaacaaa atggacaacg 1242361 atgacctcgc tcaattgctt gaagaaatgg acgaagaact gaaggaacag cttttatcca 1242421 gcatggaagc gtcagaatca aaagctgtac agctcttgat gaattacccg gctgattcag 1242481 cgggacgcat gatgacaaac cggtatgtgt ggatccctca gcattacacg gtaaaagacg 1242541 cggtcgtcaa actgaaaagc ttcgctgaaa tagctgaatc gatcaactac ttatatgtta 1242601 ttaatgaaag caaacagctg gttggggttc tttcctaccg cgatttgatt ctgggtgaac 1242661 ctgaagaaaa ggtgcaggat ttaatgttta cccgcgtcat atcagcagat gctcttcagg 1242721 accaggaaga agttgcccgc ctgatagaac gttacgattt tttggcaata ccggttgtag 1242781 aagaaaacaa cgtgcttgtc ggcattgtga cggttgatga tattatcgac gttgttattc 1242841 gggaagctga tgaggattac gaaaaatttg ccgcttccgg taaagacatc acctttgaca 1242901 caaaagctta cgtggcggca taccggcgtc tgccatggct gattttactc ttatttatcg 1242961 gactgatttc aggaagcatt atcagctatt ttgaagacgc gctgaagcag gttgtcgcgc 1243021 ttgcgttttt catgccgatg gtgtcaggga tgacaggaaa tacgggaaca caatctcttg 1243081 cggttgtcat cagaggtttg tctaaagaag aaatgaacaa aaaaacgatt gtgcgcctga 1243141 tcttccggga gttcagaaca agcattttta tcggagcggt ttgttctgtg ctgattgcga 1243201 ttgtttctat catatggcag gggaatgcgc ttttgggatt tgttgtcgcc tcttcactgt 1243261 tcttaacctt aatcatcggc acgatgtcag gaacgattat ccctattatt ttgcacaaac 1243321 tgaaagtaga cccggcgatt gcttctggac cgctgattac aacgttaaac gatattttat 1243381 ctttattaat ctactttggc attgccactg cattcattca ctcattataa acgtaaaaag 1243441 tccgtctcaa ctgcgagccg gacttttatt atttaacggt ttttgtaccg aaagtgagca 1243501 ttaagctgcc cctccagcat ttttttccgc acttgcggat cgttttttaa catctgttct 1243561 tttttgcgca tatcctttaa aatctctgcc gtctgtacgc cgtcttcacg cttattggcg 1243621 atatccatca gccgctccac atcggcaaag gagtattttc ttgtccccct tgaagaacgc 1243681 tgcgggtaaa tgagctttcg ttcctcataa tacctgatct gtcttacgga caatcctgtc 1243741 aattcactca caattccgat tgaaatcact tttttgtctt tataagaatg atcttctgtg 1243801 gtcatttttc cacccctgga tgtcttttga taatagtata taaaaaacaa agagaaaaaa 1243861 cctgacgctt gtcatatttt ctaacatcaa atagaagatt tttgaaaaaa tacggaagaa 1243921 aaattaacaa gaataatgcg taacacccaa gcgcgtttta tcctttatgt aacgaatcaa 1243981 acgaggagga aggataatca tggaggaaga aaaagcagtc tcactggcaa aagaaattat 1244041 agagttggat atcaagcgtg atgaaatgct ggagacgttt atgcagcttg ccggagaaca 1244101 ggcttttcaa ttattaagat cggttcaaaa cggacaatac cgaaaatctt cgtaaacata 1244161 aattctttac attagattca taccacgttc atttaaaaag agtatctttt gtataggata 1244221 cctcaaaatg aaggaggacg ctatgagtaa tttattgaaa tccgctttag aaaaagaacg 1244281 acgccattat tctgaaaaac tctatcagat aggggtttat aataaagagg tcatgaacaa 1244341 aatgacgatt tctgagcttc ggaaagaata cgcttatttc tttcgaagca ttacaaatca 1244401 taaaaattat ccttatacaa gataatgtat aaggattttt ttgcttttag aaggaatttc 1244461 tcgaattata gcgaatacgt atagtaaggg actgaactct tattatatgt aagggttttc 1244521 attatttttt tataaaaatc ctatatacga ggtagatatg atgagattat cgtttaacga 1244581 agaagaagtt gagcgtgcga tgaatttgta cagagttttt gcaagggctt tcaaaagtgt 1244641 gtccgaacat agtatccgtg atagcaaaga gcacggtttt aatcccactg aatttgctgt 1244701 actggaactc ctgtacacaa gaggcccgca aaaattacag caaattgggt cgagacttct 1244761 gcttgtaagc ggaaacgtca catatgttat tgacaaacta gaaagaaacg ggtttttagt 1244821 aagggagcag gacccgaaag ataaacgctc tgtttacgca catttaactg acaagggaaa 1244881 tgagtatttg gataaaattt atccgattca tgcactgcgt attgcgagag cgttttcagg 1244941 tctttcgcct gatgaacagg accagctgat cgtcctgctc aagaaagcag gcatacacag 1245001 ccagcatttg ctgtttcgtt aactattcta cactctctat ttcaggagag tgtttttttg 1245061 tttccatatg attcttttta aaacatcttt aatcttccta tcagacattt cgccaaggta 1245121 tccattgacg tgttttttat actccttcat ctgttcgttc gattgaaaaa atgccgcgat 1245181 atactcttct gctttctgca tgtcccagtt tctcatatct gtgacgagtt tcctttcatg 1245241 tagaaggttt aaattcattt cctcctgtcc cggcagtgca tgataaataa ataccggaag 1245301 ccgtttctgt aagcattcac tgatggtcac gcctccgggt ttagtcatga tgcctgtcgc 1245361 ctgttcgtac aaacggttca tctctgcttt gctgtgaagg taaggaatcg cctcaatcaa 1245421 ggggtggtgt aaacttttga cataggagta gagcttttcg tttctgccgc ataatatttt 1245481 gtataagatc tttccgcctg gcgacagttc ctgcacccat tttaaaatcc caccgacccc 1245541 catactgccc cctgtgatga tgatggtata tggcgggtgg tgctgcaagg tatctgctga 1245601 ttccatttca aaattttggt gaactggaat gccggtcaag tatatgttgt tctgatcgat 1245661 accctctgat attagctgct tctttacttc cgtgctcgga acaaaatggt aatcaatgtt 1245721 cttccgtccc cataattgat tcacgaaaaa atcagtgtat acattcacaa ccgtcagatt 1245781 cggatattca ggctttagtc ggttcagcag ataagaaggc agcgcatgtg tgcagaaggc 1245841 gatatcaggc tgtttttctt ggaggatgtg cctcatttgc tgtgtgaaca gccattcgta 1245901 catgaaatag cgtttgtcat gctgaaattc tccgcaggcg aggagcctgt aaatgccgct 1245961 gtacgttttc gggaaatatt gaatccattt taaataagcc acggaggaca atttttctaa 1246021 ccgcctatac gaatgtgaaa agatatcaat cttttcagct gccagccctt gagactctaa 1246081 ttcagcctgc aatgcatcag ccacatgatg atggccggtg gaaatgctta aaaaaggaaa 1246141 aatgagaatg tttttcatga cagtcctcct aaaaaaatat ggcaactata ttttgaggag 1246201 aacgttcaca aaatataagg gtgtttttga tcataaggaa ggtgaaaaga tgaaaacttg 1246261 tttcctttcc atatggagag tggttgatcc gatttatttc tttttttcaa ggctaagctt 1246321 gattgacaac gatcaaaaaa gcgtttttcg agtcaggctg acgaagtaca aaggacatca 1246381 tgtcgtgctt agcgacggaa cgcatataag aaaaaatgat gtgctcgtta aaatccacct 1246441 gcataacata aagctgatca gggagctgca aagcattgag agcgcagtca gaaagggaat 1246501 cattatttat cagaaagtat atcaatcgat gccgcttctt cttgactata tcaacaatca 1246561 taaaaaaagc gagaaaatca aaggaatcat tgggattaca atgcttgaca aaggtgtgga 1246621 aaggctcggc tttgatgtga tcaccccggt gaaccctttt tacagatgct ttaaaaaagt 1246681 gtctcatgtg ccgattttat atttgacttc aaagcctgtg agcttgcggc atttaccgaa 1246741 ttcatcctat ttgtttatct caaaagaaaa gctgcagaaa acctatcaaa aaaaagactg 1246801 atgcctcggt cagcacagtc ttttttgatt aaatctgatg aaatgtcact tcagggcggc 1246861 ttccgacacg gatatttacg ccggtttgtc ccaagccctc gctgatataa aatggtttat 1246921 cgtgatgata atgaaggcct ttaatcatgt tcattcgcac gagctttccc attttcacca 1246981 aatgatacgg ttttggccag tgaatttgcc cgccgtgaaa atgccctgac agcaggtaat 1247041 cataatgaac atctttcata tccagaataa tatttgggtc atgtgttaag acaagatgat 1247101 agccattttc cagactttga taagagccgg tgatattact ccgattcgta ctgtaatcat 1247161 caatgccgat aatattgact ggtcctgcag ccgtctcgat tcgaacatgt tcattttgca 1247221 gcgtgataca gccgttttcc tctaaaactc gcttcaatct ctgaaagtcc tcttctttca 1247281 atacataatc gtggttaccg aacaccgcgt acattccata tgcaggcttt agcttttgca 1247341 aggcgttcaa gtaacctgcc agtttcggaa tattacgttt ccgatcaaga aaatccccgg 1247401 taagagcaat gatgtccaca ggctgatctt ttgttaaatg atacagctcc tcaggtgaga 1247461 ctgaaatgtt ttccaagtga agatcagata aatgaaggat atttaatttt tttctggctg 1247521 gaaggccgtc tttttggtcg attgaaatgg tgttgacttt cacatctttt gtattgcggt 1247581 tcgctttata tagaaatggc acaaatacga gtatggccaa tgaaagtaag attgtaaaca 1247641 aaatatatcc cctcccttct atcagtatag taagtgatca agccctatgg atagcgggaa 1247701 ttaatgggta gagacaggtt gaaaaacgga ttgtcatatg atgaatgatt tggaagggaa 1247761 aagggataat aaattttgac acatgaggca gaacatgccg acggagtcag aataacaaat 1247821 ggatgtgtaa gcaatgttac gattgatgag acaacaaaaa aaagaaacat attatctctg 1247881 gatcgcatta tttcttcttt tattgtatgt atccccgctt tttattttaa aggaagatgc 1247941 ccatatccgg gtccacgata atttagattc caacatcgct tggtacaagg ttctggccga 1248001 tagcggagaa atcgtcggca aggttgacgc tgccattccg caaatcatta acgggctgcc 1248061 ccgggatgcc tttggcaccg agtggagcgg aattgtttgg ctccatgctt tcttttcttc 1248121 catgaccgcc tatgcaataa gccagacggt tacaagagtt gtcgcttttt ttggaatgta 1248181 tgtgctgctg aagaaacata taatcccgga accaaaagcg gctttcatcc gaattggcgt 1248241 atcgcttgca tttgccttaa caccgttctg gccttcggga atgctgagta cgcttgggta 1248301 ccctttggca ctgtgggctt ttttaaatat ccgaaaaggg gatatctcat ggagagagtg 1248361 gctgacgctg ggcttgctcc ctctatactc aagctttgtt ctaggcttct tctttttcct 1248421 ggcagggatg gcgtgttttt ggctgtatga tgccattaca aaaagaagat ggaatttgat 1248481 gttcttaggc agtattgcat ttatgacgag tatctatctt ttcgttgaat atcggcttgt 1248541 ctattcgatg ctgtttgagc acgcaccgat gcatcgtatc gaatttatct catctaggca 1248601 tgacgtttgg cattctcttc gactatccat aaaaaacttt gtctatggcc ataatcatgt 1248661 gatgaccgtt cataccgttg tcatccttcc gatcctgatg gtcgtatttg ctgctctgct 1248721 gttcaaacga aatcggacaa agccagaaaa tgtttatctg tttttatgtg tgcttaatta 1248781 cgggttgtca ttatggtatg cgttttggtt caacaaaatt tgggctgttc caaagcagaa 1248841 atttgctttt ttagcagaat ttaattttgc ccgttttcat tttcttcggc cgcttgttat 1248901 atacgtgagc tttgcgcttg ctttatatct catttggcgg atggggaaag gatggaaatg 1248961 gcttgtgtac gccgcagtcg ctgcacagct gatggtgttg gcgcctttta atgaagaata 1249021 tacgtatggt gttcattaca acgcgccgac attcagggag ttttatgcat cagagcaatt 1249081 caaagagatt aaggaatata tcggacgtcc gcaagattcg tatagggtgg cgagcatcgg 1249141 actgcatccg tctatcgccc aatataacgg gttttatacg ttagatacgt ataacaatct 1249201 gtatccgctc tcatataaat atgaatttag aaaaatcatc gaaaaagagc tggaaaaaaa 1249261 ttctcggctg aaacaatact ttgatgaatg gggcagccgc tgctaccttt ttgtcgatga 1249321 actcggtaaa cgatatgatt tcaaaaagaa ctcgaagaaa acgatcaaca accttcaatt 1249381 aaatacagat gtatttaaaa aaatgggtgg acggtacatt ttttcttcag ttccgatcat 1249441 gaatgctgaa caaaaccatc tcgcgctcgt aaagacgttt gaccataaag attccgcctg 1249501 gcgcatttat ttatatgaaa caagataagg aggatatcga ttgaaacagt cacagccagt 1249561 attaaccatc gtcgtcccgt gtttcaatga agaggaagtg tttcaagaaa caagccatca 1249621 gctgacagag gttgtagatg atttaattga agaaaaatta attgctgaag acagtaaaat 1249681 tctgtttgtc gatgatggca gcaaagaccg cacttgggct ttgattgcta tggagagcat 1249741 aagaaacaag aaggttaccg gcttaaaatt agcctgcaat gtcggccacc aaaaagcgct 1249801 tttagccgga ttgcataaag cgaagaatag gtcagactgc gtcatttcga tcgatgctga 1249861 tcttcaggac gacatctctg tgatccggga ttttatgctg aaatatcatg agggctgcga 1249921 gatcgtttac ggtgtacgcc ggagcagaaa aaccgatacc tttttcaagc gcacgaccgc 1249981 gttagggttt tatcgtctca tgaataaact tgggattaaa ttaatttata atcatgctga 1250041 ttttcgttta atgaataaaa ggtcccttga agagcttgag cgttatccgg aagcgaatct 1250101 gtttttaaga ggtattgtcc ccatgatcgg ctttaaatcg gccgaagttt tgtatgaccg 1250161 caaggaacgc tttgccggca aaacgaaata tccgctgaaa aagatgctat ccttcgcttt 1250221 taacgggatt acttcattca gtgtcgcacc aattcgattc tttacgcttt tagggtttgt 1250281 tttgtttttc ctcagcgctg tggcagggat tggcgcgttt attcaaaagc tgctcggcca 1250341 tacgaatgca ggctgggcgt ctcttatcat atccatttgg tttttgggcg ggctgcaatt 1250401 gatgggaatt ggaatcatcg gagagtatat tggaacgatt ttttctgaag tgaaaagacg 1250461 gccgaaatac gcgattgata ttgatttgta taatgaacag ctgagcccgc ttcagcgcca 1250521 ggaaaaagag cggttagaaa aaaagtacag ttaaacacgg aaagagctga cttcattagt 1250581 cagctctttt tcttcaactg atgcaatata gcgctaagcg gttcgtcttg cgggttgcgg 1250641 taaaaatcaa aaaatgggca gccctgcttc ttaattcgat cgatgaccgt atcaattgta 1250701 aacagagcgg gtgttaaaga tgattgcacc tcatgccagt agagcggggc tgcaacagtc 1250761 ccaagctcat ttcctctcgt tgaataggga cagataatcg tttttccttc tgcatgctgc 1250821 aaataatcaa gatacaattt gcagtgtctg tttttaatca agcgttcagt ggtaaagagc 1250881 tcgggaaatg cattggtgca gtactctgcg atcagctgcg taaattggcg tgtttcttca 1250941 tacgtaaatg cctcgggaga caagggaata taaagctgga tgcctttgtt gccggacagc 1251001 ttcgggtacg atgtgatgcc aaaggaatcc aacagccgct tcagttcatt tgcggcctgc 1251061 acggccataa gaaagtcatc tcgcgaaggc gggtctaaat caatgacaat ctcagccgga 1251121 cgcctgcttt taatggtttg aaaaggaacg tgaaactcca aagcaagctg gttgcaaagc 1251181 catagcaatg tagacatatc ctcacagaca atatgttcat ggcttccatc atagaaagac 1251241 tgaacaaaat ccggcgcata gtccggcttg tttttttgga aaaatgattc gctcctagat 1251301 ccatgcggat agcggatgac ggtgacagcc cggtttttca gaaatgggag caggtagtca 1251361 ctgacttcaa tcatatactg aataaaatct tcttttgttt ttttattctt ttcaaatatg 1251421 attttatcca ggcttgtgaa ctggagcttt gggtgaaccg gtttggagtg tcgtatgact 1251481 tgcgcatacg tgcattcggt ccagtccatt tggaattcga aaccgataaa cgatacctct 1251541 cttaatgtgc cttggagaat tgttaagtat tgaacagctg cacaaatcga aggttcaagc 1251601 gtaaattcgc ctgagggtgt ttgatgtccg tgctgttcca taatctcgcg tatagcgctt 1251661 ttttcctcat cacgcattcc gtgcgagaca gaggcaatcg gtgtcattat tccgtttttt 1251721 aacaccgata ccgtcagaaa cccgttgtta gggttgaacc ctgttatgca aacataagct 1251781 tgtttaaagt ttttatattt gagccaatcg gacgaccgct tcttttcaag ccatttgctg 1251841 tttgttttct tcgctacaat tccttctccg tcatatttta ttaccatctc ccagagttga 1251901 tcaaaatgat cataacaggg aatggattga atggtttctt ttgcgtaagg atctggagat 1251961 gcaggaagct ttgctgcgga tatgagttca cgcagcgatt ttttgcggtc caaatacgaa 1252021 agaagcgtta catcttctcc gcttcgctct aacaaatcaa aggcgagaaa gcagcacggc 1252081 cgcgcgtttg ccgattcctg aatcttgtct ggccttttca aacgcccccg cacttgaagg 1252141 tgttcaaaat ctgcacgaca gggattcacc aaacatacga tttcaccgtc aagtgtcagc 1252201 ggaagctctt tttctaggtg ctgaaaggca gttttggcga attgtgtgat ttcagggaag 1252261 gtgctgctga gctccacacc atttctgctg gttaaggtca cacctgaaga atggatgcgg 1252321 agaatacagc ggtacccatc atattttact tcgtaacgcc attctgctcc gattggcggt 1252381 gacgaagtta agaccggctg catggtaaac gccatgcgct atgatgtgcc ggaggctttt 1252441 tttctagttg ttttttgttt tttatctccg gctcctttcg gttcagcggc ttgtgcaggt 1252501 gcggcagccg gtgtctcccg gttcggcctt ctggttctgt cgatgctggc ttgcagagcg 1252561 cttaccaggt caatgacatc ttcacgaggt ggcgctttat caggagtgac agccgtttct 1252621 ttattttcta gcttgtcgtt gactctttgc agcagcgcct gtcggtacgt gtcttcatat 1252681 ttctcaggct caaacttagc agtcagttca tctattaatg tgatagcagt ttgcagttcc 1252741 ttatcgttta cattcgattg atcaggtaca cctgggactt gagcggcgct tctgacctca 1252801 tcgggataat ggatagactc catgacgata caattttcat aaacgcggag aatcgccagc 1252861 tgctgctttg acctgattgt catattggcg ataccgatct ttccggttga gcgcagcgcc 1252921 tcacgcagca gggtataggc cttcgtccca ttatccccgg ggccgacaaa gtaggagcgg 1252981 ttaaaataaa tcggatcaat ttcctgaagc tgaacaaagt caacaatctc aactgctttc 1253041 tcctcatgct cctgttttaa gctttttaaa tcttcgtctg tcagcactac atattttcct 1253101 tttacatatt catatccctt cacaatttca tcaggactaa gagttttttc gcaatttgtg 1253161 caaactttct cgtatttgat tggtgcgtga tcctctttat ggaggctgcg cagtttaata 1253221 tctttatctt ctgtggccgc atatagcttg atggggatgt ttactaatcc gaagctgatc 1253281 gatcccttcc acattgtatg catatcgata aacccctttt tttctttagt gtgaagagaa 1253341 ggagtacgat tcatgtgtag taacttatgg gtgaaaaaaa gccggcgctg ttattgcgac 1253401 ggctgttcaa taatgaattg ttcgaattgt tccggaggta ttggcctgct gaaaaagaag 1253461 ccctgcaaat ggtcgcagcc tttttcaaaa agaagctgct tttgagctgc attttccaca 1253521 ccttcggcaa tcacctgcaa agacagctga tgccccatgg caataatagc tccggtaatt 1253581 tgctctgatt taggatgggt ctgaatatcg tcaataaatg atttgtcaat cttcagcctg 1253641 tgaatcggga agtccttcaa atagctaaga gagctgtgac cagtaccgaa atcgtcaata 1253701 ctgattctga ttcctaattc tgttagggat gacaaaacct ttttggagtg attgagattg 1253761 tccattgtca tgctttccgt cacctccact tcaagaagct gcggaggaag ctggtactta 1253821 ttaagcgtat ccttgatgag gggaatcaga tctttagatt gaaactgtct ggcggaaata 1253881 ttaatggcga cagaaagatc atagcctttg tcatgccaaa tccttgcctg cttgcatgct 1253941 tcatctataa tccactttcc gatatcaata ataagtcccg tttcttctgc aacaccgatg 1254001 aattctccgg gcggacgcag ttgcccgtct ggtgtcacaa ggcgtatcag tgcttctgct 1254061 cctgtcattt tttgtttttt cacactgaat tgcggctgat aatgcaagac aaatctatcg 1254121 ttttcgattg cttctctgag taccatctct tggttaagct taacggtttc tttgttgccg 1254181 attgaaaaag aatagtatct gtatttgctt ttgtttcgtt ctttagccgc atacatcgcc 1254241 atatcagcct ttttcatcaa ttcaaggcca tccgtcccgt cttttggaga tatcgcaatc 1254301 ccgatactga cagatgtgac aagggtgtga tcttgaattt tgaaaggttt tttgaatttt 1254361 tggataattt ttcttgctaa aacatctgct tcgcctgttc ctgtattggc gtctgttaat 1254421 ataataataa attcatcacc gccaagacgg gcgataaatc cgttatcagg gactacagat 1254481 gacaggcgtt tagctgcaaa ctgaagcaat tgatcaccga cattatgccc taatgcatcg 1254541 ttaatcactt taaaccggtt taagtcaaga aagaatacaa cagtgttata atgcaaggaa 1254601 tgctcgcgat tcagcacctt tgttagatga gagatggcat gccttctgtt aggtaagtct 1254661 gtaagcgaat cataatgagc cattctatgg atttcttttt ctgctttgta ctgcttcgtc 1254721 atgtctttac aaatgacata aatgctgtct agttcctgat tgacctcaac aggtataagc 1254781 gtaatattta agtgaaactg gcctttttca gtgataagat cgctatcgct gttcatcgct 1254841 tgtttatctt ttttaacttg ctcaaaaagg cgcttaacct tcagtgatgt gtaattcctc 1254901 cagtcatgca tgctgaagcc aaatttgctg atcatttcct caccagcgtg attggaagat 1254961 attatgtctc cttctaatga taaaataaaa attgcatcaa tattgtggac gattaaagac 1255021 tgaaatcgct gttcgttatc ctttatgcgt tcgctctgtt taataaactt tcgatctgca 1255081 tgggaactga ataacaataa cgtttggata caaaaaataa ttaaagtaac aaaaattgac 1255141 caatgaaacg tttgcacctc catatggctt ccgggcggag ccatgtcctt atggaaagtt 1255201 gccgcaagca tccctgtgta gtgcatgccc gaaatcccaa tgcccattac aattgaactg 1255261 acgcctttat agaatataag atgctcagaa tgttttttta cggccaagtc aaagaatatt 1255321 tttaacgaga cgaaagaggc tgcaatcgca atgataattg aaactgtaaa taaaataggt 1255381 tcgtaaataa tcattacccg ggaaatggca gacattccga tatagtgcat agaagcaata 1255441 gatgcgccaa gcacaactga tccggtaagc agtctgtaat atgtaagaat gtgccggctg 1255501 acaaaatata atgacacaaa tgatcccgaa acagatgcgc caatggctgc cattaaaggc 1255561 atgaattcat attccatcgg catttccata tggacggcca tcatccctac aaaatgcatt 1255621 gaccaaatac cgaatcccat aataagtgag ccgccgatca gccaaatttt actttttaag 1255681 cctgtattga tggtgacttt ccttgaaagt tcaagggaaa tatacgaggc ggtacaggca 1255741 attagaatag ataaacatat gagagtcgta ttatatgtaa cgtgtatttc caaatggaga 1255801 ttccccccgt atcgtgtgtt ccagtcttgt tgactctctt tattatcggc tgcttaaccg 1255861 cagagtttca gccttcaaaa cgatagaaat acgagggaga tctattttta gttcaactga 1255921 ccgtgaaaaa tgtgttaaaa tcatcttgat gttttccgaa aagagaaaaa tgtatgatac 1255981 ataaacatga aacaagggag ttggtggcta tcgaagagct ggttatgtca tggattgaag 1256041 catttaaaag cttatcttat tttggaatat ttctagcgct cagcattgag tttattccgg 1256101 ccgaagtcgt cttgccgctt gcgggctatt gggtatctaa aggcgatatg acacttgctg 1256161 gcgttgtttt ggcaggatcg cttggaggag tggccggtcc gcttacgctg tattggatag 1256221 gccggtacgg aggaaggccg tttcttgaac gttttgggaa gtatctcttt attaaacctg 1256281 aagcgcttga taagtcagat aattttttca aaaaacatgg gggctttgtc gccttcagcg 1256341 gccgtttctt gcctggtatc aggacattga tttccatacc gtgcggaatt gcaaaaatga 1256401 atgtttgggt gttttcgctt tatacattca ttgctatgct tccgattaca tttgtatatg 1256461 tttatctcgg tgtgaagctc ggtgaaaatt ggaaggcagt cggctctatt cttgatcaat 1256521 atatgcttcc gatcgggata gcgattttgg cgctgttcct gctctactta ctgatgaaaa 1256581 agaggaagaa acgcacgcac tccgaacaat tatctgtatt tttgaaaaat aaacgttgac 1256641 aaatcactgc gctgcgcata ttattgacgt ataaaatcat atttcttgaa atcccaaagg 1256701 ggagtagcgt ccggaatgta ttccggaaac aaagtcgtca tttcatggat tgtatccatc 1256761 ggctttgttg gcatgcctga attcatgtct agcaagacct ttgccttatg tcggcaaagg 1256821 tcttttttgc atggtccggc cggcataaga tcggatgaag agaaagaaaa caactttttt 1256881 gggagggtat catttatgga tgcagcatta ttattagagt atggttgggt tcttctcgtc 1256941 ttgatcgggc tggaagggat tttagccgcc gataacgcgc tggttatggc ggtaatggta 1257001 aaacatttgc cggaggaaaa aagaaaaaaa gcgttatttt atggattggc aggggctttt 1257061 gttctgcgat ttggctcttt atttgcaatt tctttcttgg tcaacgtatg gcaggttcaa 1257121 gcgattggcg cgatctattt gctgtatatc tcagcaagcc acttattgaa aagatatgta 1257181 tttaagaaag aagacacaca taaagagacg aagcaaagcg gtttttggcc gactgtttta 1257241 aaagttgaac tggcagatat cgcgtttgct gttgattcca tcttagcagc agtagcgctg 1257301 gcggttacac ttcctgggac atcactcccg aagatcggcg gacttgacgg aggacaattt 1257361 ctcgtcattt tggccggcgg tatcatcgga ctggtgatca tgcggtttgc ggcttccatg 1257421 tttgtgaagt tattaaagga acgtccaagc ctagaaacag cagcctttgt gattgtcggc 1257481 tgggtcggag tgaagcttgc tttatatacg cttgcccatc gcgacatagc ggttgtttct 1257541 gagcacttta tccattctgg aacatggaag ctgatattct ggggtgtctt agcagcaatc 1257601 gcggtttgcg gctggtttat gtcaggtggg aaaaaacagc cggagggtgc acaaaacgaa 1257661 caaaaaaaca gcacccgtga acgggcgtaa tctgaaagac tctgcttaaa agcagagtct 1257721 ttttgtgttt gaagcgtttt cataagcgaa ataaaataac atttttataa catctttgtt 1257781 acaaaaaaca cgcataaaac ccccttaatt ctttagaaag gcacgaaatc atgtatagaa 1257841 cgtcagaatg gtttgtcata attgagacat tggaaatcaa tatttctttt tctcctttgc 1257901 gaatccctat caaattagct atcattaatg agtagttata gggaggaact gaggtgaaac 1257961 cagtgcttag ccttttgttt aaattgggaa aaaagaagca aacacttgaa aaagctgttg 1258021 agagtataca aaaaggcaat aaagatctgc aaaatgaatt aatacagcaa tataagccat 1258081 ttatcgcaaa gacggtttca tccgtttgta aacgatatat agatgaaaaa gacgatgagt 1258141 tcagtattgg actgatcgcg tttaatgaag ctatagaaaa atattcacct gaaaaaggaa 1258201 attctctgct cgcatttgct gagcttatta taaaaagaaa agtcattgat tacattagaa 1258261 aagaagccag aagcgcacaa aatataaata tcgatttaca ggaaggagac gatcaggagt 1258321 catcacaaag cctgattgaa gccgagcttt ccattgatga ataccgccgt cagattgaac 1258381 aggagcagag gcgggaggaa atcctctatt ttcaaaagca gctcaaggat tatggtttat 1258441 cgtttaaaga actgcttgaa aattctccaa aacacacgga tgcaaggcaa aacgccataa 1258501 aggtggcaat gacgcttgtt gaacatgaag aattggccgc tatcctgtat acaaagaagc 1258561 agcttccggt caaacagctt gaacagcttg tctctgtaag ccgaaaaacg attgagagaa 1258621 acagaaaata tattattgcg atgtgtatta tcattacggg tgattatatt tatttaaaag 1258681 attatcttaa aggggtgctg cactcatgag aagagggatt atagtagaga aaaataaaaa 1258741 attcgtcacg ttgctgaccc ctgacggaca atttttaaaa gccaaaaatg atcgacacag 1258801 ctatgaaatc ggagaagaaa tcatgcttcc gagtgaaaca cgcatgggca gaagggccag 1258861 cttttttgat ttttttaaac tgcgcccttt caaaatgggg atttttacga tgactgctat 1258921 tatgctcttt atttttatag ttctccccgt tttttctaat aataaggcct atgcgtatat 1258981 gacaatcgat atcaatccaa gcgtcgaaat ggcgttaaac agcgattatg aagtgattga 1259041 actgacgcct ctaaacgatg agggacagaa agtcgtgaat gatatagatg attgggagaa 1259101 gactgatttt aaaaaggtga ttgacgatat tataaccgac tgcagtgaac acgggtatgt 1259161 aaaaaaatcg aaagaaatat tgatttccac tgtttatgaa aacacagaag acaatacata 1259221 taaaaaggct gtgaaaaaac agctgaatga tgtgactgaa aaatataaaa cgacataccg 1259281 catggaatct ctcgagtcag atatgcaaac gagggaaaaa gcgaagaaag aaggcgtctc 1259341 aacaggcagc tacatcaaat caaatgaaaa gaatgacaat aaagatataa aagatgactc 1259401 cagcaaacca tccggggaag aggatcaaaa gagtgatgaa aatgaggatg aaaacaccga 1259461 tcaaactgac acccaggaca gcaagcaagg agataatgaa cagctgaatg atgcggattc 1259521 cggagaccag aaagaagaga aagcggatga ccagattgat gatagtgaca aagataaaaa 1259581 aataaaggaa tcagatgaaa acacaaatac cgaaaaagat ggggaccatg agcaaacccc 1259641 aatacaagat cctcaagata aaggaaatga aaataacggc gctgacaagg gccaaagcca 1259701 atatcacagg gactggaaca atggtgaaca aggcaagaac cgttcttcgt ccagaaggga 1259761 taacgcttca gaccgacgta atccaaacgg ctacagcagt gataatcatt cagctaaaaa 1259821 tgaagattcg ccgagtgccc ccggcgaata aagacctgaa tttatttagt tgtgccattt 1259881 aattgtgatt gtgcttgctg taccagccgc tttgtcattt ctccgcctac agagccgtta 1259941 gcgcgtgcga ctgtatcaga accaaggttc acaccgaatt cttgagccac ttcgagttta 1260001 aattggtcta gtgcctgctc cacccctgga acaacgagtt tatttctgct cgccatcttt 1260061 ttcatctcct ttttcgataa agaaattctt aacgcgtatt tagtttgaaa tatacggggt 1260121 ttatttatgc tggcaattgt tgtggagaaa aataaaaccc cggcctctga gccggggtgg 1260181 cgcagactat agaatgtctg ctgtcatttt atgtgcggtt gcctgaatat ggaatgtcaa 1260241 aatggagagg actgtaatgg cgataatctg tctgatttta agccattggc tgtcattcag 1260301 ttcttcaaaa cggtgacgga gacgctctgt ctcctgttcg gcgatctcct gcagatttga 1260361 ttctttcata gaaggagtat cttggtgatg gatggcatca agcacatatg cgcagctttc 1260421 ataataagca atcgggctga tgacatcatc agatctgtct gagattgtgt taaaggccac 1260481 ttttaaaata gcccgtatgt gttcaaagtc ataaatggat tttaaatcac gtacaattaa 1260541 aagaataact gcctgttcaa ttgagtattt tttgcccagc tcagggtgtc cgatcagatc 1260601 tttgatatca cgctttaccc agttttgaat cgcggttgac tttaacgaag tcagctcgca 1260661 taagttgcca agctctacga tttcatttgt agacagaccg tattcttttt tctgtttttt 1260721 tcgttcgtat cttgtaagaa attcaggaat ttctagatga ttggctgctt tttctgctga 1260781 catgttcgct gattggacga gaatgtcgag cgggctatgt tctccttgtc cttttaggga 1260841 atagagcagc cgcaccatat cggttcgaga gagtttaaaa atgttcattg ttcacctctt 1260901 taaacaattt gacgcggata taggtctatg tataagttca aaattcaagc gtcagcaaat 1260961 tacattaaca tcatacgtcg aattccttgc attttcaaat ggatgtttta taatttaaat 1261021 atacgggttc ttttgaactt aaaataacgg aggttgttat ggcgaaaaga atttttctgt 1261081 ttattctaac gaatattttg gtgcttacaa caatcgggat cgttttgtct gttttaagct 1261141 ctgttacagg agtcgggacg tactttacag ctgatggcgg tatcgatcca atggcgcttc 1261201 ttgtgttcag tttagtcgtt ggatttgtcg gttcctttac gtctcttgcg atatccagat 1261261 ggatggcaaa gacgatgatg ggcgtcagag tgctgaatcc gaaaaaacac tcgctcagct 1261321 atgaggaaca gcaattggtt gatcgtgttc acagattaag ccgctctgcc ggtttaacga 1261381 aaatgccgga agtcgggatt taccgttcac ctgaagtaaa cgcgtttgcg actggaccgt 1261441 caaaacgccg ttcacttgtc gcagtatcgt cagggctgct ggagcagatg gatgacgcag 1261501 cagttgaagg tgtgcttgcc cacgaggtcg cgcatatcac aaatggtgat atggtaacaa 1261561 tgacgctttt acaaggtatc gttaatacct ttgtcgtctt tttatcgcgt atcgccgctt 1261621 ggatagcaag ccgttttgtc aaagaagatc tagcgccgat cgttcatttt attgcaatga 1261681 ttatttttca gattgtcttt tcgatacttg gcagcctggt tgtgtttgcg tattcacgcc 1261741 atcgtgaatt ccatgctgac aggggaggag cggatcttgc cggcaaggac aagatgattc 1261801 atgcgctgcg gacgcttaaa agctattctt cccggatttt ggaagacgat cagacagctg 1261861 tccaaacgtt aaagattaat ggcaagaagc gctcttcact tttctctact catcctgatt 1261921 tagatgagcg aatcagacgg ctggaagcta aataatacaa acacattgtt cctctgagag 1261981 aattctcaga ggttttttat tttatccatt gactaaaatc ataaaaaaat aagcaagtta 1262041 agaaaatgtt tcgtaaaagc ctttaaaaat ggacctaata tctttagaat aattaccgta 1262101 cttaaaaaga gaggcagaag gattttacat gagattaaag tttggaaaat tgatacaggc 1262161 cttgtcaccg gcccagctga tcgcattata ttattttctt gcagttactg tggccgttat 1262221 attgctgagt ttgccggcgg cccataaacc gggggcggat tggacgttta ttgatgcgct 1262281 ttttacagct gtcagttcag tcagtgtaac ggggctgaca gttgttgata cagctgatac 1262341 attcagcaca atagggattt ttatattagc atttgttctg caatttggcg gaatcggaat 1262401 tatgacgctc ggaacgttca tttggctgat catgggaaaa cgaatcgggc tgaaagaacg 1262461 gaagctgatt atggttgatc aaaaccaatc ccagttttca ggaattgtca atctgatgaa 1262521 gcaggtactg tttctgatct tgtggattga attttttggc gggctgatac tcggcacata 1262581 tttcttaacc tactatgact cctatcagga agcctattta cacggatttt ttgccagtat 1262641 cagtgcaacg acaaacggcg gatttgatat taccggtaat tcgatgattc catttcgcca 1262701 cgattacttt gtgcagttta ttacaatgct tttaattata tttggagcga ttggatttcc 1262761 cgtgcttgtt gaagtaaagg atttcctgtt ttcaaagcat cggcgttatc catttacgct 1262821 ttttacaaag atcacgacga ttacgttcgg ctcacttgtc ttgtttggag ccattggcat 1262881 ctttgccctg gaagcaaacc atgcgttcgc aggaaaatca tggcatgata ttttgttttt 1262941 gtccctgttt caatcaacgg caacccgaag cggggggctg gcaacaatcg atatcagcca 1263001 attatcagat tccacactct tttttatttg tgcgctgatg tttattggag cgtcgccaag 1263061 ctcagtcggg ggaggcataa ggacaacgac ttttgctttg aaccttcttg cgctgtttca 1263121 ttttgcccgc ggcaataagg ccgtaaaggt attcaaacgg gagcttcacc ctgctgactt 1263181 gatgaagtcg cttgttgtca cgatgatggc gatcctgctc gtttttggcg cgacactcat 1263241 tctgaccatt acagaaaaac attccctgct ggagcttttg tttgaagtgt gctcggcatt 1263301 cggtacaacc ggcctatcgc ttggaattac ggcagatttg agcagtgttg gaaaatgcgt 1263361 cattatgatt gtcatgttta tcgggcgaat cggcatcttg accttcctgt atctgatcgg 1263421 aagaaaggaa attgaagcga attatcacta tccgaaggaa agagtgatta tcggataggc 1263481 aaaacaccgc atattttgcg gtgttttttg attaccaaaa aaaagatgtg tgcctcctgt 1263541 tcagttggag aacctaactc cgacaggtgc aatttacgct cctgcatctt aaaatgtctg 1263601 aaaattggcg aggaggattc gtatgaagcg taaagctgaa gtgaatgaag ccattaaaaa 1263661 taacaataca cctaccgaga gcatggaccc caattcatat aagacacaat atcatgacga 1263721 ccccaatttt agaggggcaa accgcaattc caaacagggc cagcagggag gcatgtaatt 1263781 gtgaagaaaa accgtcatag cagagacatg caaaatcata aaaagcctat gaataaaaag 1263841 gtgctggagg aagaattctc aagtgaactc ggggattaca atgccggaaa gatcatcgaa 1263901 acgctggaag tcaccaagcc tgaaaagaaa aaagaaaaaa acaaaaaaca acaataaaaa 1263961 agacctctta ggcggcgtcc cgcttaagag gtgctttttc tattttaaat aagcattttt 1264021 gcccgttcct ctgacaaatt gcaataagct tgtcatcctc agctcaatga atggctgagc 1264081 gactgtctta acaaagttgc tggagaggac tgatgtcagg gctgctgtta aaagcaagag 1264141 gatcactaag ctttgatagt cagtaagcca atcctcaagc ccgacctgcc gtaatgtctt 1264201 aataataaac ccgtgaagca gatacacgta aaatgtccgg gttccccatt tggtaaagaa 1264261 ataccgtttt tgcggaacga gcgctaaaaa gctgaaggtt gccccaaagg cgagtacata 1264321 ccagccgatt cgggatagtc cgcttaccag ggtaacgtct ccaaatgaag aatacggttt 1264381 tgaaccaaac agaaaagaat agtcaaaatc gatgccccag cagatgacga atactgcggc 1264441 aagcactccg agcgcaattt gtttgccgcg ttttgatctc aataaatcaa aatgatgttt 1264501 atttaaataa aaaccgacaa ggaacatcgg taagaatacg aatgtccgtg acaagctcag 1264561 cgtgctgctg acaaagtcca gataaccgat cagcacggcg attccgcagc tgacaaacag 1264621 cgcccactgc tttgaaagct ttgaaaaagg atataggagc aggttccaaa agaataagct 1264681 tacaagaaac cataacgacc attgcggatc aatcgggttc acatttgcca tgctttcatc 1264741 ttgcataatg taataaaaga cggaataaat aatttggaaa atcaaatacg gaataatcag 1264801 cttgaccgcc agctttttta catatcccgc ccgtttaaag cctttcgcga aataaccgga 1264861 tacaagaata aatgcaggca tatggaatgt gtaaatgaac ttgtagaggt agagcataaa 1264921 atgattatca ttaataaagg aacgaaggat atgaccgaat acaacaagga atatcaataa 1264981 aaattttgcg ttatcgaaat aactgtcccg cgatttactc atagcatcac cttctctttc 1265041 atcagtcact aagagattat tccctgctgg tacatatttt aaaataaaag atgaaaaagg 1265101 aatctaaaaa aatgctgatt gttaggtcga tgtaaagtga cggtaaggat cgtagaaaat 1265161 gtcttcgtaa tgtaatgacg ctgaaatttt ctgaaattta tagggcaaat gaaggaagtt 1265221 cccgcatttt gtagaaatat tgagggatag gttttgaaga aggagtgtac atgcatggaa 1265281 actcttggtg tccagacaaa ctcggagctg cgagaggaac tgaatcgcct caaagaagaa 1265341 aacgcgcgac tgaaaaagga attgaatcag catcaagtga ttgtcaacaa tacgctcgat 1265401 gctattttta tttgtgataa cgaaatgcgg attgttcagg caaatgaagc aacagaaagg 1265461 atgcttcaag ttgactcgga agatttgaaa aagcgttctg ttttggattt tttgttttca 1265521 atcccaaagg atgaactgaa tctttccgta aagaagtttt ttaaaaaagg ctttctgtgg 1265581 aaggaggttc cgatcaggct tgattgcggg gcaacaaaat acatagagtt tctggccaaa 1265641 agaggtattg gtgaggattt cttttttgtt gtcatgaggg acatatcttc taagaagatt 1265701 ctggagcggg aattctctat gaatgaacag ctttttaagg acttgtttga cagagcagtt 1265761 gacggaatcg tcctgtttga taaagatggc ggttttattg atgcaaattt gtccttttgt 1265821 aaaagctttg aaatcaatca taatgagctg tctcatttat ctttgtatga gttcatagac 1265881 agcggctcac gaaaagattt cgacaatatc tggaaggcgc tcaaccgcaa gggaaaagcg 1265941 aagggggagc tgcctgtcaa gcttcgttca ggagttcaaa aactatttga attcacgatt 1266001 acatcaaaca tcatcagcgg tttttatatg tccattatga gggatatcac agagaagcgg 1266061 tctatggagc tgcagctctt taaaagtgag gagcgcttca gagaaatctt tgaaaatgca 1266121 atggacgcca tcatcatctg gtcgaatgac ggaagaatcg taaaagcgaa tcaatcagcc 1266181 tgtaaaattt ttgagctgcc gatgaatttg ctgttgaaaa gaaagctgtg tgattttctc 1266241 gttgactcgc agcagaaata cagcataacg aagaggaaat acgcaaaata cggagagatc 1266301 agagaagagc tgctgtttca aatggggaac ggccaattca aagagcttga atttacttca 1266361 aaacggacaa tccttgaaaa tcagcatttg acgatcttaa gaaatgtaag cgacagaaag 1266421 cggatggaaa aggagcttcg ggaaagcgag ctgaaattca gaaaagtgtt caacggatca 1266481 atggacggca atgtattgtt cgacaatcaa tacaggatca tcgacgccaa cccgttagca 1266541 agccatattt tgggcctgtc acatgaagag atcaaacagc acagcctgtt agatattatt 1266601 tctgcttatg aaatagaaaa tttggcatca ccggcaaggc agattaattt tgatgaaatg 1266661 gacaacgaaa ttccattttt gctgagcagc ggtgataaca gaaaactcga attctcattt 1266721 aaacggaata ttattcaaaa tatgaacttg gctatcttta aagacgtaac agagcgaaaa 1266781 gaattggagg agcgcctgcg caaatcagat acccttcatg ttgtcggcga actcgcagcc 1266841 ggtattgctc atgaaatcag aaatccgatg actgctctta aaggcttcat tcagcttctg 1266901 aaagggagtg tcgagggaga ctacgccctt tacttcaacg tgatcacctc agaactaaag 1266961 cgcatcgaat ccatcatcac cgaattcttg attttagcca agccccaggc cattatgtat 1267021 gaggaaaaac atgttaccca aattatgagg gacacgatag accttctaaa tgcgcaagcc 1267081 aatctcagca atgtacaaat gcaacttgat ttaattgacg acattccccc gatttactgt 1267141 gaaccgaatc agctgaaaca ggtttttatc aatatattaa aaaacgccat cgaagtgatg 1267201 cctgacggcg gaaatatttt tgtaacgata aaggcattgg atcaagatca tgttctaatc 1267261 tccttaaaag acgagggaat cggaatgaca gaagataaat taaagcgact tggtgaaccg 1267321 ttttatacga caaaggaacg gggaactgga cttgggctta tggtaagcta taaaattatt 1267381 gaagaacatc aaggcgagat tatggtagaa agtgaagaag ggaagggcac cgttttccat 1267441 attacgcttc ctgtcagaca gaatgctgaa gaaagaagga atgatgaatg aactactata 1267501 cgacagccga aacgccgctc ggtgaactta tcattgccga agaggaggac cggatcactc 1267561 gtctatttct cagtcaggaa gattgggtgg attggaaaga aacggttcag aatactgagc 1267621 ataaggaaac acctaatctt gcagaagcga aacaacagct tcaagaatat ttcgcaggcg 1267681 aaaggaagac attctccctg ccgctcagcc aaaagggcac tccttttcag caaaaagtgt 1267741 ggcaagcgct ggagaggatt ccatatggcg aatcccgaag ctatgcggat attgccgctg 1267801 ctgtcggcag tccgaaagcg gtgcgcgctg tcgggcaggc taataaacgt aacgacctgc 1267861 cgatttttgt cccgtgccac agagtgatcg gcaaaaacag tgcgttaaca ggatacgccg 1267921 gaagcaaaac ggagatcaaa gcatttttgc taaacatcga gcgaatctcc tataaagaaa 1267981 aataaaacat atggcacgtt cccttttttc acggccgaca tatcatttta ttaagttaaa 1268041 aaagttggtc tgatgaaaaa ggaggacaaa gcaattgaag ccgagccgct ctgagaaact 1268101 tgccgttttt gccgaactgt ttgtgaaact gcatatctta tcaagcgctc aaaaagatga 1268161 aatcatcaat gttaacaaaa agaaacaaaa aaaccgctga ctcggctcca aatgagcaaa 1268221 gtccagcggt tttttaatgc accttttctc ctttaaacag ctgttcaatc tcttcttcat 1268281 agtttccggt cataatccct ttttctgtga tgattcctga aatgagatca tgaggtgtaa 1268341 tgtcgaaagc gggattaaag acaggcacat tggatggagc ggtccgaact ccggaaatct 1268401 gcctgacttc ctcgggatct cgttcctcta tcgggatatc agcgccgcat ttgacctttg 1268461 tatcaaatgt agataaaggt gcggcgacaa aaaacggaat atcaaaggcg tttgctaaaa 1268521 tagcaagacc gtatgtgccg attttatttg ccgtatcacc gttctttgca attcggtcgg 1268581 ctccgacgat aacagcggaa atttgttttt ccttcatcgt atgggcggcc atgctgtctg 1268641 tgatcagagt gacatcaatg cccccctgca tcagctccca agcagtaagg cgtgaacctt 1268701 gcaggacagg ccttgtttca caggcataaa tgtgtaatcc caaatctttt tgtttggcca 1268761 agtaaaacgg agctagcgcc gttccatagc ggcttgtcgc gattgagccg gcattgcaga 1268821 tcgtcatgat cctgtcgcct tttttgaaaa gctgcagggc gttttggccg atcaaccggc 1268881 acgtttcctc atcctcgacc tgaatctgaa tggcttcatg gacaaggttt gtttttgctt 1268941 catttacgga aatcgcgttt tcgaccgaat gactcagtct ctcaagcgcc catgacaaat 1269001 taatggcggt aggccgtgag ctgtttaaat attgtttgat gtcttccagt ctgcggcgga 1269061 attccgtgac attgtctgtt tcaatgtctt tggcagcaag cgccagtccg aaggcagctg 1269121 taatgccgat cgccggagcg ccccttactt tgagcgtgac aatcgcatca aatacatcct 1269181 ctttcgtcgt cagctccaaa tattccgtct catcaggaag cttttgctga tttaaaatgg 1269241 taatagctgt ttctttccat tcaacagaac gtggaacagc aaatgaatgg gtcatgaata 1269301 gatcattcct ttacaagtaa cttaaataat tcaataacat ctgttatcgt tttgaattcc 1269361 gaacgttttt cgataaaggc tgtgccggtt tcgagcgcca agcgttttct gccgattcgt 1269421 ttatcaaacg gcacgatcgt atccaggtca gctacatggg caaggccgat cgtgcgtcgt 1269481 atcagctcac agcccgcaaa tccgattgct tcttcaaaaa tatggctgag cgtatcagtg 1269541 aggtaaccgt cgatgttggc gtaaacatcc agactgtcct tctgccaggc ttcactaaac 1269601 gtctcttcaa acgtttccca gacctggttg acatgttcat ataacggctc tctgtcagcc 1269661 ccgtcacggc tgagtgcgtt caaaaataag ttggcgataa attgccctac atcaaagccg 1269721 atcggtccgt aaaaagcaaa ctcaggatca atcacctttg tttcgtgctc acttgcgaaa 1269781 atgcttcctg tatgcaaatc accatgaatc aacgtttctg cagacgttaa aaatgacttt 1269841 ttcagcttag cggcttcgat tttaacgctg tcattattcc aaagcttttc gacaaaagga 1269901 cgaagctctt cttcaaaatc atttgtgtca tggtcgaaga aaggatctgt aaaaacaagt 1269961 ctttccgtaa tgtcgcatag ctctggattt gtaaactgtt taacaagctg ttttttcacc 1270021 ttaggttcaa gcgcgtaatc tgatgagtag aaaagtgttt ttcctaaaaa ttcaccgatg 1270081 tgctgcgaca gatgaggata gttttcaccc tcaatgagtc cttttcttgc gatcttgagg 1270141 tgagagagat cctccatgac ggtaaccgcc atttccgtat cagaataaaa cactcttgga 1270201 accaggtgag gcacatgctc gccctgacgg atgagagcgc tgctttcgat tcttgcacgg 1270261 tcgattgtca gcggccagct ttctcccacc acttttgcat acggaaccgc ctgtttaatg 1270321 atcaatgctc tgtcatgttc ttgatcataa atatgaaaaa cgtaatttaa gttgccgtct 1270381 ccgatctcct ggcatgtcag cgtgcttttg cttggaaata ggccaagctt caccgccaac 1270441 gccacagcgg agctttcatt taacgtttcg tataaaggtg tttttgtgac tcccatcatc 1270501 ataacctcca attatgtaat taattaatat gtggccgtaa aaaagcctcc ttctcagaga 1270561 gaaggaggct taacatctat gtccgcctct cttatctctc agatcagatc tgaatggaat 1270621 tagcaccgtg ccttaagaga ccagcgtctc ggcgcgaaaa aaatgcgccc catttcacaa 1270681 tggaattacg gtcggttgct tttggggtca aaaggccaaa tccctcgccc aactctcgat 1270741 aagagaatat attcacttgt ttgacaattc taatttatca gttgatgaac atggtaacag 1270801 gtaatttagt tagttgtcaa tatatttttt aatataaatc ttttctgata tcatcgaaaa 1270861 caggaatgct ctcccgaact tctgcgcttt cttgaaggtc gatttccgct cggactatgc 1270921 cttcttcccg gccgccttca gcaagtacac gtccccatgg atcaataatc aggctatgtc 1270981 ctgcaaattc attatccgga tttgaaccgg tacaattgca ggctgcgaca aagcattggt 1271041 tttcaatggc ccgcgcaata agcaggcttt tccaatgatc aaggcgggga agaggccatt 1271101 ccgcagaaat aaacagcacg ttggcgcctt ttgtcgtatg ttttctgatc cattccggaa 1271161 aacggatatc gtaacagatc aatccagagc ttttgacgcc gtcaagctca aagtatccgt 1271221 cttcggaacc ggctgataaa tacagatgct catccatcag ctgaaaaaga tgggcttttc 1271281 tgtactcttt aatgatttgc ccttccttat ccgcgatgta cattgtatta taaacatcag 1271341 aattcttcct gacagcgacc gatccggcga caatatgaac accatgtttt tttgccgttt 1271401 tcttcagcca gctctgagcg gagcggccgt cttcgtcagc gagttcatca agattggcca 1271461 gatcatatcc ggtcgtccat aattcaggca gaacaagaac atcagcatgt ttgctttctt 1271521 tttcgatgaa aaattcagcc ttttttatat tttccgaagg ttttccgtat gaaatatcaa 1271581 attgaagaca agatatcgtc catttcatct ttttaacacc ccaaattttt ctttactttt 1271641 ttcatttaac catatatgat gatggactat catttcaaga tttttttaga aggtgagaat 1271701 agatgaaatt tgaacagtct catgtattga aggaattgcc taaacaattc ttcgcttctc 1271761 tggtgcagaa agtgaaccga aagcttgcag aaggacatga cgttatcaat ctgggacagg 1271821 gaaatccaga tcagccgact cctgagcata ttgttgagga gatgaaacga gctgtcgctg 1271881 atcctgagaa tcataaatat tcgtcttttc gcggctcata ccgtctgaag tcagcggctg 1271941 ctgcatttta caaaagagaa tacggcattg atctggatcc ggaaaccgaa gtcgctgtat 1272001 tattcggcgg aaaagccggt ctagtcgagc tcccgcaatg cttgttgaat cccggtgata 1272061 cgattttagt tcccgatccg ggttatcctg attactggtc gggtgtcaca cttgcaaaag 1272121 caaagatgga aatgatgccg ctcgtaaagg acagagcgtt tctccctgat tacagcagca 1272181 taaccgctga aataagggaa caggcgaaat tgatgtattt gaattatccg aataatccga 1272241 ctggagctgt tgctacttcc gagttctttg aagataccgt gcgttttgcg gctgaaaacg 1272301 gaatctgcgt cgttcacgat tttgcttacg gcgctgtagg atttgacggc tgcaagcctt 1272361 taagcttttt gcagactgaa ggtgcgaagg atatcggaat tgaaatttac acgctgtcaa 1272421 aaacgtataa tatggcagga tggcgggttg gctttgccgt cggaaacgct tcggtcattg 1272481 aagcgatcaa tctttatcaa gaccatatgt ttgtcagtct tttcagagcg actcaggagg 1272541 ctgcagcaga ggcactgtta gccgatcaga cgtgtgtggc agagcaaaat gccaggtatg 1272601 agagcaggag aaacgcttgg atcacggcat gccgggaaat cggctgggat gtaacagctc 1272661 ccgcaggttc tttttttgca tggctgcctg tgcctgaagg ctatacttct gagcagttct 1272721 cagatctttt gctggaaaaa gcgaatgtgg cagttgcggc tggaaacggc ttcggtgaat 1272781 atggcgaggg ctacgtcaga gtcggacttt taacaagtga agaaagactt aaggaagccg 1272841 cttatcgaat tggcaaactg aacctgttta cccaaaaaag cattgacaag accttataac 1272901 gatgggataa ttcaaaataa tttataaaat ctatattttc ttatcaagag caggcagagg 1272961 gacgagcccg atgaagcccg gcaaccgact tataaagcac ggtgctaatt cttgcagcta 1273021 gcggctgaga gataagattc ggacgagaaa cgaaacctct ttagacgcga ttgcagtttg 1273081 aagaggtttt ttgatatgga tgaaaatgaa aggagctctg gcatgagtga gttattagcg 1273141 acatatctcc tgaccgaacc gggagccgat acagagaaga aagcagaaca aatcgcaaca 1273201 ggattgacag taggctcctg gactgatctg ccccttgtaa aacaggagca aatgcaaaag 1273261 cacaaggggc gggtgataaa agttgaggag agagagggaa ctgctgcatc agaaaaacaa 1273321 gcggtcatca caattgccta tcctgaaatc aatttctctc aggatattcc ggctttgctg 1273381 acaacagtgt ttggcaagct gtccctggac ggaaaaatca aattaatcga tcttcacttc 1273441 tctgaagcat ttaagcgtgc actgccggga ccgaagtttg gcgtatacgg catccggaag 1273501 ctgctgggag agtttgagag accgctgtta atgagcatat ttaaaggcgt aatcggaagg 1273561 gacctgagtg atattaaaga acagctccgg cagcaggcgc ttggcggagt tgacttgatt 1273621 aaagacgatg aaattttctt tgagactggt ctagcgcctt ttgaaacaag aattgcagaa 1273681 ggaaagcaaa tattgaaaga aacgtatgaa caaaccggac ataaaacgct gtatgcggtg 1273741 aatttgaccg gacgtacggc tgatctgaaa gacaaagcga gacgcgccgc cgaattggga 1273801 gcggatgcgc ttttgtttaa tgtcttcgct tacggcttgg acgttatgca aggccttgca 1273861 gaagatcctg aaatcccagt tccgattatg gcgcatccag cagtgagcgg agcgtttacg 1273921 tcttctccgt tttacggttt ttctcacgct cttttactcg gaaaattaaa ccgatattgc 1273981 ggtgctgact tcagcctctt tccgtctcca tatggttcgg ttgcgcttcc aagagcagat 1274041 gcactggcga ttcatgaaga atgtgtgaga gaggatgctt ttaaccaaac atttgctgtt 1274101 ccgtcagcag gcattcatcc cggcatggtt ccgctattaa tgcgtgattt cggcatagac 1274161 cacattatta acgccggagg aggcgtacat ggacatccga acggtgccca aggcgggggg 1274221 cgagcgttca gagctattat tgatgcggtc ctagaggccc agccgattga tgaaaaagcc 1274281 gaacaatgca aggatcttaa gcttgcgcta gataaatggg gaaaggctga agccgtatga 1274341 cgactcgaaa accttttatt atttgtgatt ttgacggaac aatcacgatg aacgacaaca 1274401 ttataaatat catgaaaaca tttgctcccc cagagtggat ggcattaaaa gacggcgtac 1274461 tttccaaaac gctgtcaatc aaggaaggtg tcgggcggat gttcggcctt ctgcccagca 1274521 gtttaaaaga agagattaca agttttgtat tggaagatgc aaaaatcagg gaaggctttc 1274581 gggaatttgt agcatttatc aatgagcacg agattccgtt ttatgtcata agcggtggaa 1274641 tggacttttt tgtatatcct ttgcttgaag gcattgtgga gaaagaccgc atttattgca 1274701 accatgcttc atttgacaat gactatatcc atattgactg gcctcattcc tgcaagggca 1274761 catgcagcaa tcaatgcggg tgctgtaagc cgtcggtcat ccatgaactt tctgaaccga 1274821 accaatatat catcatgatc ggtgattcgg ttacagatgt ggaggcagca aagctgtctg 1274881 acctatgctt tgcaagggat tatttattaa acgaatgccg ggagcaaaac ctcaatcatc 1274941 ttccgtatca agatttttat gagatcagaa aggaaattga gaatgtaaag gaggtacagg 1275001 aatggctgca aaacaagaac gctggcgaga gctcgctgaa gtaaaacggg aattggcaga 1275061 gagagattgg tttccggcga ctagcggcaa tctgtcaatt aaggttacag atgagccttt 1275121 aacatttctc gtcactgcaa gcggaaaaga taaacgcaaa gagacggttg aagattttct 1275181 gctggtcgat caaaacggag agcctgctga aagcgggcat tctctgaaac cgtcagcaga 1275241 aacgcttttg catacacatt tgtacaataa aaccaatgcc ggatgctgcc tgcatgtcca 1275301 tacggtaaac aataatgtga tttcagagtt atacggagac caaaagaaaa tcacattcaa 1275361 aggccaggaa attataaaag cactcggctt gtgggaagag aacgcagaag tgaccgttcc 1275421 gattatagaa aatccggcac atatcccgac gctagcggca ctgtttgcgg aagagatttc 1275481 agaagattca ggagctgttc tgatccgaaa tcatggtatt acggcttggg ggaaaacagc 1275541 atttgaggca aaaagagtgc ttgaagcgta tgaatttttg ttcagctacc atttgaaatt 1275601 gaaaacactc gagcatcagc tggttaaata aaaggaggaa ttgaaatggc tacaattcga 1275661 attcatgatg aggcaaatac aacgattgaa aatcaagagg aagtggcaag ctttctggac 1275721 agtcaagagg ttatttatga gcaatgggat atcacgaggc ttccggaaca tctctcagag 1275781 aaatatgacc tgacagaaga agaaaaacag caaattcttg ataccttcga aactgaaatt 1275841 aaagatatct caacccgccg cggctataaa gcacaggatg ttatttcatt gtcagacagc 1275901 aatccgaaac ttgatgaact gcttgaaaac tttaaaagag agcatcacca tacagacgat 1275961 gaggttcgtt ttattgtaag cggacacggt atttttgtca ttcaaggcca ggacggcacg 1276021 ttttttgatg tccgtttaaa ccctggagat ttaatctccg tgcctgagaa tatccgccat 1276081 tacttcacgc ttcaggagga ccgcaaagtt gtcgcggtga gaatttttgt cacaactgaa 1276141 ggctgggttc ctatttatga aaaagacagc gtgaatcaat aagcgtgaga tagccccgtt 1276201 catcgaacgg ggctttttat atttattgca aacgccactt ttcatattgt gacagttctt 1276261 ttttaatcag tgtccaaatc aaacctaaaa cagctgcatc gtcaatgaat ccaagaccga 1276321 ggattacgtc tggaatgata tcgagcggca tgacgatata caggattgcg gcagttaaca 1276381 gcaaaagtgt tttaacctgt gaacgagggt agtcgccatt tcgccaatcg cgaagcatct 1276441 gaaaaaaagt agtgatgtgc tggatacatt tttttcggtt tttcctcttt aaaatcgctt 1276501 ttccgcctgc cgctccgagc attattgctt tctttttctt cattgggcat acctcctgcc 1276561 tggcggcgtg tttaagatat tcttcacctg ggtattgttc ttctaatcct atcaatatat 1276621 ctattatacc tgaaaaatta acttatttaa tgaaaatatg tttacaaata aagtataatc 1276681 tgtaataatg cacaataacc caatcaaact tgtttcctat ttcttagcgg cgaggggtga 1276741 agtgaatggg cggttcttct gaacaagaaa gattgttggt gtctattgat gaaaaaagaa 1276801 agttaatgat agatgccgct agaaagcagg gatttacagg gcatgacacg atcaggcaca 1276861 gtcaggagct ggattgttta ataaatgaat atcatcagct tatgcaagaa aacgaacatt 1276921 cccaagggat tcaaggcctt gtaaagaaat taggcttgtg gccccgcaga gatgttatgc 1276981 cagcatatga tgcaaataaa tagcggccta tcagatgcat atataaagag agagcttttc 1277041 ggaagcgctc tttttttctg gaaaaaattc atatgaaaga gggaactaat gaaggaactg 1277101 gcgattctca ttaccgaaat ggtcaatcaa tttcatgatg cttttatttc cttatgcgga 1277161 atatttggca ttcatttaac tgacaaagaa atgcattttt gggtgatcgg catttttggc 1277221 atattctttt tcggcgtcac tcacgctgtg tttacatggc tttctaaatg gagtatgaca 1277281 gccttgtcct ttatctatac cgttacagtc atcattgtca tcgtatttgc gattgagatt 1277341 cagcaaaagg tgacggggag agggaatatg gagtttttag atgccacgga aggtataaag 1277401 ggttttttag tattttttat gttttttttg cttttgaaaa tgctgttgcg tttcatcaaa 1277461 atcctttttt ctggaagacc agcaagcaaa tcgaatggca atgcccgatc acgaagataa 1277521 aaaaccctcc tgacatggtc aggggggcta tgatgcggat acggggaggg tgatcgtcac 1277581 ctctgtgcct cttcgcactt cactttcaat atgaatagag cctccgtaca tcagcacgat 1277641 ccgtttacaa acaacaaggc cgagaccggt tcctttttct ttagaagtaa caaagggaag 1277701 gaagatgtga tccagcattt cctgagaaat cccttcaccg ttatccacaa ctttgattat 1277761 ggctttttta tctaaagctc ctagggagat cgtcagtttg cctccttcag gcattgactc 1277821 gaggccattt tttgctacat ttaaaatcac ttgtttaata tgatcttttg tacattttac 1277881 gagtaagggc tgctcggtta gatactgtaa ttcgacttca acattgtata gattgccctc 1277941 agaataaatg atcggcataa tttctccgat aatgtcctga agtgagttca gctcccattt 1278001 ttcagctgtc ggcttgccga gaacgagaaa ctcactcact atttgattga tgcgctttat 1278061 ctcctgttcg ataatggaga agtaaagctg atcttcctca cctttatatt tcttttgcaa 1278121 cagctgaata aagccgctta tcccggtgag ggggttacgg atttcatggg ctgtgctggc 1278181 agcaagcgtc ccgatcagct ctaatttttg cgcctcgttt tctgagcgct ccagctgggt 1278241 ctgccgcttc agcaaataat acagcacgag aataaaaagg atattcagca gaacaataat 1278301 acatgaaagc ggaagcacaa ggcttttcga cagttcttct attgtgaccg ggttcggata 1278361 gactttcata ttccagctga tatcatccag atatccgctg acaggtttct gatcctctgc 1278421 atgagaggct tgtccgctcg caaaaatcat tttcccgtct tggttcacaa cttcaatata 1278481 aacatcaggg cttagtaagt taatgagatt tttcaaataa tcaatttgaa tagctgcgac 1278541 aagataatct gtcacattac gttttgagtc caaaacaggc acacaaattg tgaaaattgg 1278601 ctgaccagta attctgctcg aataactatc tgaaatgact gtctttttag tttcctttgc 1278661 ttttataaaa aaagatctgt cggccaggtt tactttcgtt tttaattcgg ttgtgcttgc 1278721 ggtgacgtct cctttggcat tgagaaaata gagaccggaa aatctcggct ctgaatcaaa 1278781 ggtcttttcc aaaattgatt gcattttctt tatatcaacc ggtctgtcga tggcgatgga 1278841 caaggaggtc attctcgcca ttgtttctcc gattaaataa ttgattttgt tgcggtgaag 1278901 gtttagcagg acacttgctt cttgtttatg ttctgcagct attgtatctt tttctttttc 1278961 atatacgaaa aagctgatga cgattgccgg aatcacgacc agtatgatat aaagtttgac 1279021 tctcccgcag gcgcctttta gtattttcaa tttgcatcgc tccaacatac acctgattag 1279081 aggtattata tcattgtttc ttcttcttta ataagaaaaa ataaccaaaa aaattagaaa 1279141 aagatgttgg caagcttaca ttttaaaaaa gaagagaaat attggaaaga tttttattga 1279201 cattttggtc tttgtttatt aatgtttctc tgtaacggtt tctaaaagga tgattgagac 1279261 atgacagaaa aatcactgaa gttatttatc gtgctgtcgc gcgcgtatcg gtctattaac 1279321 gatcatatga ataagcatat tcataagcat gggctgaatc cgactgaatt tgctgtgcta 1279381 gagcttttgt accataaagg cgatcagccg ctgcagcaga taggagataa aattctcttg 1279441 gctagcggga gcatcacata cgttgtagat aagctggagc aaaaagaact tctcattcgg 1279501 aaagcgtctc ctacagacag acgagtgaca tttgcgcaaa ttactgaaaa aggcatcggt 1279561 cttttgaacg atattttccc tgatcacgct gctgaaattg atgaaatgat cagcgtatta 1279621 agcgaagaag aggtagagat gtgcaccgaa atgttaaaaa gagtaggatt aaacgcaaaa 1279681 cagtttcata ataagtaaaa aaaggaagcc tgatatgtca caaggcttcc ttttttgcta 1279741 tttttcattt gtttccgctg cgcctctcgg caaaatgaga acttcaaccc gccggttttt 1279801 gcttcggcct tccgcagttt tattggaagc caccggttta tactcgccat aacccttggc 1279861 gctgaacact tttgcatcga gcttggggtt ttcaatcagg agccccataa agtttaccgc 1279921 tctcatgacg cttaaatgcc agtttgattg gaattcagaa tttttaattg gcatattatc 1279981 agtatgtccg ctgataatga tatttcttgg cgggttaatc acaagaagat ttgaaatctc 1280041 ttttgcaagc ggcacatctt ccttacggat ggtcgctttt ccagaatcga agaagatgct 1280101 gtctttaatc gtaatcagaa ggccttcact agtcatcttc gtctccagct gatgttccag 1280161 ctttttatct ttgatgaact tttccacctg gctcttcaca ttttcaagtt cttcttgatc 1280221 agctgctttt tctttttctt tcttgttttt ctctttctct tctttttcct ttttcacttc 1280281 atcgatgccg tctgactcgt tttcaggagg agtgacactg gagtagtcca gtacaccggt 1280341 tccgcctgta aaaacttcat taaatgattt tgagagcatt tgaaacttag ctgcgtcaat 1280401 cgagctgctc gcgtacagca caataaacaa tgccaggaga agagtaagga tgtcggcgta 1280461 aggaacgagc catgattcat caacgtgctc gtcctcatgc ttcttcttct tttttctcgc 1280521 cattttgcgc ctctccttgt tctgcaaatt tcaagcggtc cttcgcagga agatacatta 1280581 aaagcttttg ttcgatgact ttcggtgctt gtccttctaa aacggataaa acaccttcaa 1280641 tcatgacctc acgcagtttt acttcctgtt ttgattttcg ttttaattta tttgcgaaag 1280701 gatgccataa cacataccct gtaaagatac cgagaagtgt ggcaacaaag gcagcactga 1280761 tggcgtgtcc aagctcatct gtgttatcca tatgagagag agcggcaatc agcccgatta 1280821 cagcgccgag tactccaagt gtcggagcgt acgttcctgc ttgtgtaaaa atagcggctc 1280881 ctgcttggtg cctgtcctcc attgcttcga cttcctctgt cataatatct cttataaatt 1280941 ccgcgctttg cccgtcaaca gccatgctga gcccgttttt caagaaagca tcatctacat 1281001 cctcaatgct tgcttctaaa gcaagcagac cttcgcggcg tgcaagctga gcccattcag 1281061 agaacatagg aatgagttcc tctattgtga gctgtttatt ttccttaaat aacactcgaa 1281121 acagcgtagg cactttttta atttcttttg ttgggaacgc aataacgact gctgagattg 1281181 tcccggcgat aataattaaa atggcagcgg ggtttgcaag ggcgctgaaa ctgacgcctt 1281241 tcagaaccat cccgacgctc aatgccacaa aagcaagaat aataccgatt aacgaagttt 1281301 tatccatagt tttcaccaaa tcctttttta ctagcttgtc tatggttaat atcggttttg 1281361 gtgcccggaa ctttagggac attgtgaatt tgttcatgaa atattcaagg aagaggcata 1281421 gaagggagaa ataaacaaaa acgggctctc caaaattgaa aagcccgggg gtctactgaa 1281481 attagcagct tgcttgcaag ctgtccttca gatggtattc atataatagt agaaatacat 1281541 attcactgta tataaacatg ttccatccct ccttaaaaaa gtgtaaagga tgaagggaag 1281601 tagcgcttca ggagaaggga cggtaatttc taagtcaaga gtatgaaagt ataaaaaaaa 1281661 gcggcttcct aaaaggaaac cgctgattgt tattttgctc gcactttgat tttatcatct 1281721 tctaaaatca cgtgaaaact tgtgatctcg ccattatcaa gcagcagatc ggtcatttca 1281781 tcctcaaccc attcttggat ggttcttcta agcggacgtg caccgaatga agggtggtag 1281841 cccagctcag cgattttttc tttcgcttca tctgtcacat tcaagctaat gccccgttcc 1281901 gccaatgttt cttcaagttc tccaagaaga aggctgacga ttttgacaag atgttctttt 1281961 tccaatgagc ggaactcaat aatgctgtca aaacggttga ggaactcagg tttaaagaac 1282021 atgctcagtg aatcaattaa tgtttgttct tcgatgacac tgtcatctga ttggaaaccg 1282081 actttcgttt gtttctcacc agcacccgca ttacttgtca tgatgatcac agtgtctttg 1282141 aagcttacag ttctgccttg gctgtctgtc agacggccat cttccataat ttgcaggaac 1282201 atatgctgaa cgtctgggtg tgctttttca atctcatcca gcaacacaat gctgtaagga 1282261 ttgcggcgca ccttctcagt taattgtcca gcttcctcat ggccgacata tccaggcggt 1282321 gaaccgataa ttttagatac ggcgtgtttc tccatgtatt cgctcatatc gagtcggata 1282381 atagcgtctt ttgtgccgaa taattcatct gccagtgttt tagaaagctc tgttttccct 1282441 acgccggtag gaccgacgaa gaggaaggag ccgactggtc tgtttttgga ttttaatccg 1282501 gcgcggcttc gtcttaccgc ttttgccact ttttgaacag cggcttcttg tccgatcacg 1282561 cgttcatgaa gttttgcttc gagttctttc attttcgttt gttcgtctgc ctgcagtttg 1282621 ccgacaggga tgcctgtttt ttgttcaaca atttcctgaa tgtgctcagc ttccacagtg 1282681 acagcggtat gagcggagga gctgttcagt tttttctcca atgcgagttc ttcatcacgg 1282741 agttttgccg ccagttcgta attttcttct tccagggctt ttgttttttc ggcttcaatt 1282801 gcagttaagc gttcagcggc atcctcatca ttcagttcat caattaacag gttggctttt 1282861 gaacctgctt catctaataa atcaattgct ttatccggca ggtgtctgtc ctgaatgtag 1282921 cgggatgata aagtgacaca tgctttgatt gcttcatcac tgaatgttac gccatggtac 1282981 gcctcgtatt tgtctttaat cccttgcaga atgaggatag cctgttcaat tgaaggctcc 1283041 tgcaccatga caggctgaaa acgtctttcc agcgcggcat ctttttcgat ttgacgatat 1283101 tctttcagtg ttgtcgcgcc aatgacttgc agttcgcctc tggctagggc cggtttgaga 1283161 atgttgccgg cgtccattga tccttctgca gagcctgcgc cgacgagaag gtgaatttca 1283221 tcaatgaaca gaatgacatt ttttcgttcc ttcagctcag tgatcagctg tttcattctc 1283281 tcctcaaatt ggcctctgat ccctgtgttt gcaacaagag atgcaacatc aagcaagtat 1283341 agctctttgt tttttagttt gtttggaaca tcaccttcag caatttttaa agcgagccct 1283401 tcagcgatgg cagttttccc tacacccggc tcaccaataa gaaccggatt gtttttgttt 1283461 cggcggttta gaatttcgat cactcgcgcc acttcatcat cacggccgat gacgggatca 1283521 atgagaccgg cttttgcacc gtttgtaata ttttgagcca gctcatcaag caaccctttt 1283581 ttttcgcttt gttttgctgc gctctgttct ttcggctgga atgcctgttc aaacggaaat 1283641 ccgaaagatt gaggacccat actcattgaa ggtttacggg tcagttcgtt atagcaagtt 1283701 tcacaaagaa ccatctgttt atgaacggaa tttatttgca tgttaaggcg aatcgtcgcc 1283761 tcgttttgat gacaatgttg acaacgcatt tgccaaaacc tccttaataa tttgatcatc 1283821 tttgaccaat gaaagtgaat aaaaaggtct attgggtttg accttctttg actattagta 1283881 tacggcaaac ttaacggcat tcaaaccaat atgctcaaag cagactgaat atttgactat 1283941 ctttgaccaa ttgattttta aaaaaggccg gtttgtttga ccaactttga ttaatagtat 1284001 actctgacta tctttgactt tcaagtctta tgcacaaaaa tttttgattt gttacaaagt 1284061 aaaacatgtt ttcttcgtct tttcaaggaa cttgtctcat aggttataaa aaggcatata 1284121 tggacaaaac tgcggttcgt tcggagggaa gaaatggaac aatcaaaagg gtctgcaagt 1284181 cagcttgctt ttgtgtatgt cggcacagta gtcggagctg gatttgcgac tgggagggaa 1284241 attgttgagt tttttctgaa gttcggctgg ttcggttttt tcggcattct cgtcagcggc 1284301 ggaatgttta cgttactggg ggccaagctg atgatcattt caaagcgaat caatgccaag 1284361 tcatatcaag aaatgaacat atttttgttc ggggcgacgg ctgggcggat tatcaatgta 1284421 tttatgctgt ttgttctcct tggagttaca tctgttatgc tttcaggggc aggggcgctt 1284481 tttgaggaac agctggggat gtccgctcag attgggatgc tcattacaat cggtctgagt 1284541 ttaattgtga tgactagagg agtaaaaggc attttcggtg tcaatgtgtt tgttgttcct 1284601 cttttaatca tcttttcaat gattgtggtg gccgactctt ttatattcag cgaatcacga 1284661 aacgcagctc agtgggtctg gccgcatcgc tgggattggc tgttatcagc agtttcttac 1284721 ggggctttaa atttatcgct tgcccaagct gttttggttc cgctggcgaa tgaaatgtca 1284781 tcggagaaag tgataaaaaa aggcgcttta atcggaggca cgatgctgac gattgtgctg 1284841 tccgcgagtt ttctgtcttt gtcgactctt ccggatgtat ttttgtatga tataccgatg 1284901 gcgcaagtgg tttatctctt tgcacgatct gtccatttga tttatttact cattattttc 1284961 ggagaagtgt tcacatcagt tatcggtaat ctatatggat tagaaaaaca agtgcaaagc 1285021 tttcttccag tgaaaagcaa atatatcttt gcagccatta tgatcacggc ttatattacg 1285081 agccaaatag ggtacggcag gcttatttca acgatttatc ccttgtttgg ctatgtgagc 1285141 ctggccttca taggcgcttt gctttgcaaa aaagctcctc ggcggcgcag tttataaata 1285201 tatataatga aacgaaccgt cactatagag cgataattga tctaggaacc ggggactgac 1285261 ttttttattg tcaagaaaaa catcattatg gtaagatagc agaagtgaaa aaattgaaga 1285321 aaatccgtgc gatatgcggg agaggttcta gctacaccct ctataaaaaa ctaaggacga 1285381 gctgtatcct tggatacggc cttttttatg tttttctaga gcaccttccg aaaaaaggtg 1285441 tttttttgcg tgaattagct gtagcgatgt ctctcgccgg cgtttttatt gcggagaagg 1285501 agaggaatca tgaaaaaaga aaaagcaatt gtcgtattta gcggcggtca agacagcaca 1285561 acatgcttac tgtgggcctt aaaagaattc gaagaagtcg aaacggtgac ttttcattat 1285621 aatcagcgac attcgcagga agttgaagtg gcaaaatcca ttgcggaaaa gcttggtgtg 1285681 aaaaatcatt tgcttgatat gtcactttta aatcagcttg caccgaatgc cctgactaga 1285741 aatgatattg agatagaagt aaaagacggc gaactgccat ccacattcgt tccaggccgc 1285801 aatttggtat tcttatcctt tgcgtctatc ctggcttacc aaattggcgc gcgccacatt 1285861 attacaggag tttgcgagac agacttcagt ggttatcctg actgccgtga cgaattcgtg 1285921 aaatcttgca atgtcacggt aaatctggca atggagaagc cgtttgtgat ccacacgcct 1285981 ctcatgtggc tcaataaggc ggaaacgtgg aagcttgcag atgagcttgg cgcgctggat 1286041 tttgtgaaaa acaacacgct gacatgctat aacggcatca tcgcagacgg ctgcggcgaa 1286101 tgtccggcat gtcaccttcg ttcaaaaggt tatgaagaat atatggtgat gaaaggagag 1286161 cgtgcataaa ttgttatctc aaatttatcc gcaggcccag catccttatt cgtttgaact 1286221 gaataaggac atgcatatct cagccgctca ttttatccct cgggaaagtg cgggagcgtg 1286281 cagcagggtt cacgggcata cgtataccgt aaatataacc gttgccggcg acgaacttga 1286341 cgattcaggc tttcttgtca atttcagcgt actcaaaaaa ctggtgcacg gaaactatga 1286401 tcacacgcta ttaaatgatc atgaagattt ttctcaggac gaccggtatt cgctgccgac 1286461 aactgaagtc gtggcgaaaa cgatttatga caacgtacag gcttatttag acactttgga 1286521 gaataagccg acctgtgtac aggtgtttgt ccgtgaaaca ccgacaagct actgtgtcta 1286581 ccgtccgaaa aagggtggtt tgaatggcta aaggaattcc tgtattagaa attttcggcc 1286641 cgacgattca aggagaaggc atggtgatcg gacagaaaac gatgttcgtc cggacagccg 1286701 gctgcgatta ttcctgcagc tggtgtgact ccgctttcac ttgggacggg tctgctaaaa 1286761 aagatattcg ctggatgacg gcggaggaga tttttgcgga gcttaaggac attgggggag 1286821 atgcgttttc tcatgtgacg atctcaggcg gcaacccggc tctgttaaaa cagctggatg 1286881 cttttattga actgctgaag gaaaataaca tccgtgcagc gcttgaaact caagggaccg 1286941 tttatcagga ttggtttacg ctgattgatg acctgacaat ttctccaaaa ccgccaagct 1287001 caaaaatggt aacgaacttt caaaagcttg accacatttt aacttcactt caagagaatg 1287061 atagacagca tgctgtcagc ttgaaggttg tcatctttaa tgatgaagat ctggaatttg 1287121 ccaaaactgt gcacaagcgg tatccgggaa tcccgtttta tttacaagtc ggaaatgatg 1287181 acgtgcatac gacagatgat cagtcactga ttgcacattt gcttggaaaa tatgaagcgc 1287241 ttgttgataa ggtagctgtc gatgcggagc tgaatctcgt cagagtgctc ccgcagctgc 1287301 acaccctgtt atggggcaac aaacgcggag tataatagaa aggaagatga acatgacgac 1287361 aagaaaagaa tcagaattag aaggtgtaac attgctaggc aatcaaggta caaattattt 1287421 gttcgaatat gcaccggacg tgctggaatc cttccctaat aaacatgtaa accgtgatta 1287481 ctttgtaaaa ttcaattgcc cggaattcac atctttatgt cctaaaacag gccagcctga 1287541 ctttgcgaca atctacatca gctacattcc tgatgaaaaa atggttgaaa gcaaatcatt 1287601 aaagctgtat ctattcagct tcagaaacca tggtgacttc cacgaggact gcatgaatat 1287661 catcatgaac gacttgattg aattaatgga cccgcgctac attgaagtat ggggcaaatt 1287721 cacgccaaga ggcggaattt ccattgatcc gtacacaaac tacggaaagc ctggcacgaa 1287781 gtatgagaaa atggccgaat accgtatgat gaaccatgat ttgtatccgg agacaattga 1287841 taatcgttaa ttattccgtt gtgtgatacg gagtgtaaaa ggaagtggag tcacagtaaa 1287901 atccgaacat tcagcgttaa ttttcagcgg aaatgtgacc tggtcacagc gaagtgtgac 1287961 ccgcactaag ctcaataaaa gtgggaaaag tcacacctga aaatggctct actcatggga 1288021 attgtattaa aaagtgtgac ctgaggtgca acctgaactg tgacttttat gcagtgaaaa 1288081 attgatagta cagaagcaga ttaaggcgta caatttgtac gtcttttctt ttttatccga 1288141 aagaaaaaat gcctatctag agatcatagg cattaaatat tattatcaat atcttcattt 1288201 attttttggc taagtttctg aaccttctct ttaacatttg aaacagctct tttttgaatt 1288261 tcatcaattc tcctgaatat agtcgatgac acttcttatt agaacttcac tttcaaaatt 1288321 gaatatctca tttatttctg actgttcttc atctgttagg tgatggtatt gaagttgttt 1288381 agcatttact tcagcagcta catcaatcct aacttagttg ttctggttgt acaatttcat 1288441 attcaccttc tgcatactct tgctccgcat aatagcctcc ccattgacag agctcctgca 1288501 agataggttt aagagattct ccaagttcag tggatgaata ttcaaccttc ggcggtactt 1288561 gattatacat ctttctgctc acaagtccac tggcttcaag ctctctaagt gtttgaatca 1288621 gcattttctg agttatattt gggataatgc gctttaattc actcgttctc tttggtccat 1288681 tcattaaaaa gtataataca aggcctttcc attttccgcc aataacttcc tttgtcactt 1288741 caaacccaca gctaaatttt ttcatgtcta aagctctcca ttccacattt attacttttt 1288801 agttactata tcacaaaaaa gtgggtactt ccgataatgt gcttactgaa ggatactata 1288861 tcttgtaagt tgttcttcaa gtacttaaag gtactagaca taaaataaaa ttaattctaa 1288921 aggagtgtta agtatgggta aatttgaagg taaaatagcg cttgtaacgg gtggaacaag 1288981 tgggattggt cttgctacag cacaaaaatt tgtaaacgaa ggtgcatatg tttatattac 1289041 gggacgtaga caaaacgaac ttgataaagc tgttaaccaa attggcaaga acgtaaccgg 1289101 tgttcaaggt gatatttcta agcttgaaga cttagacaaa ctatatgaca ttataaagca 1289161 ggaaaaaggt aagttggaca ttctttttgc taatgcaggc atcggcaact tccttccatt 1289221 aggtgaaatt actgaagagc aggttgatag aacgttcgac attaacgtta aaggaaccat 1289281 ctttactgtt caaaaagcgt tatcactatt cccggacaaa gtaggttcta ttattgtaac 1289341 gggctctact gctggatcaa ttggcaaccc agcgtttagt gtatatggag catctaaagc 1289401 agcattaaga gcactagttc gcaactggat tcttgaccta aaaggtactg aaatccgtgt 1289461 aaatgtggtt agtccaggag gtattcttac acctgcctac gatgagcttt ttggtgatgc 1289521 acttgaagag gtactggaaa atagcagaaa tactgttcca gctggaaaag ttgggacacc 1289581 tgaagaagta gcaaacgctg tatctttcct tgcttcagac gaaagcagtt acttgacggg 1289641 tgttgaattg ttcgtagatg gcgggctagc acaggtataa tttcactgcg cagagattac 1289701 aaatagtccc caaaaaaggt taatggggat ttacttgaag aagtcgtata aaaaagtcgt 1289761 tttccttaaa ggacagggaa ttcgactttt ttatatttga atttgattaa cgttgtaaat 1289821 tcgcattttc ctggggctac tactaaatga cctgtaaaaa agattacact gtgaataaat 1289881 gtacttaaag taacgggggc tcttgacttt taataaaaaa taatatccct gtccttgtat 1289941 tctaatactt ttaaaaatat ttaaaggaat ccttatgtcc tgaataacca cataggaaaa 1290001 tatgttgtag gttgctttct ttttttgtgg ggcatcccac acaagctatc tcgtgatctc 1290061 acacctgaac gttttttata gactagtacc gcgacaagtt atattacata tacataccaa 1290121 taaagtagac attaaaaagt gaaagagagg atggaaatgt gtgaaaattc ttttccttga 1290181 gagtcatccc atgtggctct atggtttacc gaatgggttt agggaagcag gacataccgt 1290241 aatgatttcc ggtcctgtaa gtcgggaaaa tataactgaa atgatagacg aatttaaacc 1290301 agatttaata gtatctatgg gatggacacc agagcattca agggaaaagc aggcctggat 1290361 tcgcaacgct actaaaaagg tgaatatccc tctcgtttat tgggcaactg aagacccgct 1290421 gcacactcaa aactttacta tcccgttaat taaaaagatg aaaccggatt ttgttttcac 1290481 ggtcacgcct tctctgtgta aaacttatga aagcatgggg attaaagcag ctcacttaga 1290541 ctttgcattt cacgaaagta tacatcacca gattaaacca ttagcgaaat acagttgtga 1290601 tatagcagtg gtggctaatg cttaccctaa ttttcttgaa gaacatccgg aagtgttccg 1290661 ttcgtcctct ttaaaaacgc ttattcgtcc tcttatacgg aagggtattc gcattgattt 1290721 ttgggggaga aactgggaaa aaatgagtaa atatatagga agagaaattc cccgcaattg 1290781 gatccatgga taccttgatt atactgaagc atataaagtt tacagttcag caaaaatcat 1290841 tatcggtttg caaaactgtg aaagccaact tacacaacgc acctatgaga ttcttggttc 1290901 cggggggttt ttattgacat cggatacacc agcagttcga ggtaaattca aacctggccg 1290961 cgatctcatc gtttcttcct ccccaaaaga aacattggaa aaggttaaat actatttaaa 1291021 tcatgatagc gagagaaaaa agattcagat aaacggtaaa aaggctgtaa agaatgattc 1291081 ctatcggcat agagccgaga gaatgcttga ggtgctaaaa agcagaggaa tcataagaaa 1291141 cttaggggaa accattcatt atgtagatgt tctcaaagaa aaatacgtga tccatcatgt 1291201 tactcccggt gaaacattat caataattgc cagtaagtat aatgtttccc tgcagcaact 1291261 catggagctt aatcatttca aatcagatca aatatatgct ggacaaatca ttaagattag 1291321 agagaaactg tttagaaata ttaataacaa attattctaa aggagagtaa tatgaatgaa 1291381 ggggaaaata cctaaaataa gaaatcaagc gaataaagta aaaagaacgc ctcgttatat 1291441 ggaatttccc gtgacatacg aagtatatca tgtggaatcc ggcgatacat tatggacgat 1291501 tgccaaatcc tttgaaattc cggtacaaca acttatgaat cttaataagc tttcttcaga 1291561 tagaatttat cctggacaaa ttataaagat aagagaaaga taatctttga ggtttcggaa 1291621 gcgaatcaaa ttgaaatgac aatcctcatt tttttatttg tggggaactt gatatttttg 1291681 gggatgaagg ggttatgaga tgtttcaaat gagctattac tattctggat taggatggga 1291741 ctttattcaa cacgttgatc aaacgaacgg agtattaaat gttgtgtctc ctgatttttt 1291801 ctatatcaga aaagatggat cattacttct ccgttcagct aatcccgatg tgattaaagc 1291861 tcttcataga agaaaattaa aagtagttcc ttttctaagc aatcattggg atcaggattt 1291921 gggacgattt gcattaatga accgagttct tttagctaaa caaatttctc atgcaataga 1291981 agaactggat ttggatggag ttaatatcga tatagaaaac cttacagaaa aagatcggaa 1292041 tctatttaca gattttatta gattagtaag gaaaagtatt cctagacata aagaagtatc 1292101 agttgcagtg gcggcaaatc cttttggctg gacgaagggc tggcacggat catatgatta 1292161 cgagtattta gctaaatatg cagattatct tatggttatg gcctatgatg aaagccgcct 1292221 tgctgggcct actgcaagtg taggatgggt ggaaaagtcc attcaatatg ttctgaccca 1292281 aaaaatctct cctcaaaaac tagttttagg attgccattc tatggccgct gctggatgga 1292341 aggccaatct gcctctcaag ccattcccct ttaccttgtt gttagtaaaa aggcatagcg 1292401 ggacaattat ttttgacacc aagagtcaat ctccaaaagc tatttttact gtcaatcacg 1292461 ataaaaaggg gccgttgcct tcgggaacat atacattatg gtttgaaaat gaacagtcac 1292521 tcagagcaaa aataaaactc gctcaaaaat ataatctgaa aggtcttggc agctggagtc 1292581 ttggacaaga agatgcgtca gtctggaata cagtgtttaa aaatatataa tgatttatag 1292641 ttcagaacaa aattcgaaga taattgcaat gaatctctaa atggacatac tgaaaggagt 1292701 ttattacgag tgcgggtaaa acagtgaggg cattccatag gcccttctcc caaaatgttc 1292761 tacacgaggc attacattgg gcttgaaata cacattcaaa cttatgttat agtacgcatt 1292821 ttacggatgt gttgaattta ttctgcttcc atgatttaat catacacatg ctacttgata 1292881 gcagggttat cgcatttcat tcagaattgt tcaggatcga tatggaagcg cacgactaac 1292941 tagaacttta aaagcataca ctcatatact tcctgaatgg atgctggttt atctaaaaaa 1293001 catgatgaga attgattgta cgcatggtga agcatgactt gttgataatc gaccatatgg 1293061 tttctcctta gaaatgaggg ggtttttaca taaaaaagac gagcgaatcc ggggggaatt 1293121 ccactcgccg ctttctaatg aaaagacggg atgctggatg gcagctcgtc tgttttatta 1293181 taatttaacg aacgtatgtt tgtaaaggtg tcttttcgaa tgaattggtt catataaccg 1293241 ttaagaacag attcattgta aacattcgct aaggtatgct aagatgcatg gactataaag 1293301 gagtgatatg aagtgaagac attgcggtta aacaatgtaa cgttagaaat ggctgcatat 1293361 caagaggaga gcgagccgaa gcgaaaaatt gcatttacct taaacgttac gagtgagact 1293421 taccatgata tcgctgtcct gttgtatgaa aaaacgttta atgtcgaggt tccggaacgc 1293481 gatcttgcct tccgggggga aatgacaaat tattcaacat cattgaccaa cctgtacgaa 1293541 ccaggggccg tcagcgagtt ctatatagaa ataacggaaa tagacaaaaa cgccgattca 1293601 tgatcggtgt tttttatgta aaaaagctgc cggccggcag cttttgagaa agcgaatttc 1293661 atatgtaagg tgttaaattg tccgtcttgc agttttttga ataaatgtgg aaataaggag 1293721 gttttaatag gagtctctga tgatcttata atttttatga ttaacaactg tcaatgaatc 1293781 taactcaaga tcccgatagt tatccatgat cgtcacatca acgataacag aattctcatt 1293841 tactttttca acaacaccgg ttaatccgtt tttaaattca atgacattcc caaccttagc 1293901 gattttcaca agcttcctct cctttaaaca taataatgcc ttttgaaagt attttgcagt 1293961 attttcattg agaagtaaag cgataaggag ttttatctcc cttatgaatt gttctgtcgc 1294021 tataaagatg atatattgat tttcgtcaat agaaagaaaa ggggggaatt tttgttgcgt 1294081 cccgaagaaa taacagaaat gattgaacag ctgcgcaccg gcgccataaa cgaactgaga 1294141 gtccagaaag agcattttct tgatttcagg gccgtgttat ctaaacaaga tgattttaaa 1294201 catttccgag gaattgccca gcaaggcgga gatgttatct ttcaatactt agaacagcca 1294261 agaagctgaa ggtttctcat acgtgagaag cctttttatc atatatgaca gaacacaagc 1294321 cttttattac agctgtctgt aacaggtgta aataaaatgt aaagtaccaa agatggataa 1294381 acatgtttta atttaacaat atttatagaa tttcagactg tttttttgcc attaagcagt 1294441 gagtcatcct ctttattcca tcctgatacc tccttgggag agttggaaaa tctttttccg 1294501 tgaaaatgaa tggatctctt gttaaggtta tgaagtgttt tttggagcac tttaaggagg 1294561 aaactgtatg acaacgaaat tcactgctct ggctgttttt cttctttgtt tcatgcctgc 1294621 agccaaaatt gagcatacac aagcttcact actgagcgca aagaagacaa aacatgaaga 1294681 agcgaaatgg cttacacata tagatcgaaa tacgaatgaa tctttccctt cactgtctgc 1294741 tgataaagac aagaaaataa aaccgattaa gctatcagca cacactgaaa agaaagagaa 1294801 agataaaccg gacaaaacaa atgatgagaa agaaacatat acacagtctg aaaaagagtt 1294861 gctgtcccgt ctcgttcacg cagaggccaa aggagaatca tataaaggca aggtcgctgt 1294921 agcaagcgtt gtactgaaca ggacggagaa aaaaggtttt cctgatacga taagaggagt 1294981 tatttatcag aaaaacgcct ttgaaccggt cgcaaacggg agcattaacc aaaagcctga 1295041 taaagaatcg attgaagctg ccgaagaagc gctgtcctca aaaaatagag aaacagatgc 1295101 catattcttt tataatccga aaacagcgtc agataattgg attcgttcaa gaaaaatcgt 1295161 agaaaaaatc ggcagacacg tttttgccgt ctaagcatag aagagacaat ttgtctcagc 1295221 tgtgcttttt ttcatataaa gagtaaaaat aaaataattt ttgaacttgt ctcatatgat 1295281 gttggtagta caagagacaa ggagagacat catgaatcga tttgtgaaag ggatcattct 1295341 tttatccatt gccgcctttt tcgctgaatg ccttgaattt gtcgtcaata tgattttggc 1295401 gcgggagctt ggcgagcatg ggatggggct ttacatgagt attttgccca cgatcttttt 1295461 aattattgtc atcgcgagcc tggaactgcc gatatccatt tctaaattca ttgccgagtc 1295521 aaatcctaag cttcatgaaa gcatgctgag gcacgctttc agaatgacag ccatttttac 1295581 tgctttttct actgccgccg ctagtattgc gcttccgttt attccggtat ttgatacata 1295641 ccacccgttt attaaaggga ttgtcatcgg cttaattcct gttgtcgcct ttacttcaat 1295701 cgccaggggc tactttatgg gtgtgcagaa aatggggaag atcgcaattg ccaatgtgct 1295761 gaaaaaaatc atccagctct tgtgcttatt cctctttttt caatggtact catttgaatt 1295821 ggacatggct gtgctgattt ccttgtttgt tctagtcgtg agtgatgtgg tcgtgcttgt 1295881 ttatttatat tcacaattta tcatggcaag gcgggcgtta tccggccagc agcacattca 1295941 tttgcgcgga aaggatgtaa ggaaaagact gcttgctgtt tcaattccta caacaggact 1296001 gcgtattttt catgcggttg tcaatgcaat tgaacccttt ttagtaaaag gagctctttt 1296061 ggctgcgggc gttgccggga cagcggcgat cgatcaatac ggaatgctgg caggagtggc 1296121 tgtgacgata gggtcgttcc ctgcttttat tgcccattcg ttaatggtcg tcatgatacc 1296181 gagtatttcg gaagcttatg cactttctca gtatgacatc gtgttaaaaa ggctgaagca 1296241 gtcgattttc attacattag gttacggtat acctgccgtc tgggtcatgt tccagtttgc 1296301 gggacctctc acgcatttgt tttttcactc tcctgaagcg cagtattact tgcagctgtt 1296361 gtggccttac tttctctttc atctgtttgt catgccgctg caggcgtgct taatcgggat 1296421 gggttttgtg aaagaggctt tttatcacaa tgtatggagc catatcgttg cgctaagtat 1296481 gatgtatgta ctgggatcaa tggagaatct gcaaatgctc gggattatcc ttggaatgaa 1296541 cactggcatg attcttttga cgagcctgca ctatgccacg atctgcaaag cattgaaggt 1296601 atctgtattt cttacgggag ggaccagaac gccgcgaatt gaaggatgat aaaggaacag 1296661 caggggcaag ctaattgaaa agcatgaaag gaagattcca tgttgacgaa gcgcttgctt 1296721 actatataca ttatgttatt agggttgatt gcatggtttc caggtgcggc acaagctgag 1296781 gaaaaacagc ctgctgttcc cgctgttttt cttatgaaaa cgatagaagg ggaggacatc 1296841 tcgattccga ataaagggca aaaaacaatt ctccattttt ggacgtcatg gtgcccgccc 1296901 tgcaaaaagg agcttccaca gtttcaatcg ttttatgatg cccatccatc cgacagtgta 1296961 aagctggtaa cggtgaattt agtgaattcg gaacaaaatc agcaagtcgt tgaagacttt 1297021 attaaagcaa acaagctgac gtttccgatt gtccttgact caaaagggga attgatgaag 1297081 gagtatcata tcatcacgat cccaacatca tttttgctga atgaaaaggg agaaattgaa 1297141 aaaacaaaaa ttggcccgat gacagcggaa caactgaagg aatggacgga agaatagctg 1297201 agagcataga ctctcagctt ttttcatata gagaagaagt gaataaacat taatgataat 1297261 tattatcaaa aagaaattaa aataattata attgaaattc tcttcgtgcg tgctataata 1297321 aaggaagaca tcaagaaata actgacgata aagctgcctt ttgggcagcg attttgtttt 1297381 tataagagaa atgaagatga tttacgttct caattagaga ggagaattcg atatgaatga 1297441 acaagttatc gttcaacgcg acccgcatga gccattgaaa acagacaaga gggaaaaaaa 1297501 ctgggcacag cacgcggagc ttattgcagc acttgtatca ggcgctctta ttttggcagg 1297561 ctggctctta tccggatatc aggtattatc cataatactt ttcttgctgg cttttgtgat 1297621 cggcggattt gctaaagcga aggaaggaat cgaagaaaca ctcgaatcca aaacgctgaa 1297681 tgtagaactt ttaatgattt tcgctgccat tggttccgcc ttgatcggat actgggcaga 1297741 gggtgctatt ttaatattta ttttttcctt aagcggagct ttagaaacat acacgatgaa 1297801 taaaagcagc agagatttaa cgtctttaat gcagcttgag cctgaagaag cgacattgat 1297861 ggtcaatggt gaaaccaaaa gagttccggt ttcagacttg caggccggtg atatgattgt 1297921 gatcaaacct ggagaacgcg tagcggcaga cggtatcatt gaatcgggct cgacaagtct 1297981 tgacgagtcg gctttaacag gtgaatcaat gcctgtagaa aaaaacacag gcgacactgt 1298041 attcacagga acggtgaatc gcaatggctc cttgacagtc cgtgtcacga aagcaaatga 1298101 agattcgtta ttcagaaaaa ttatcaaact ggttgaatca gcgcaaaata gtgtttcacc 1298161 cgcgcaggct ttcatcgaac gatttgaaaa tgcttatgtg aaaggtgtgc taattgcggt 1298221 ggcgctcctt ttattcgtcc cgcactttgc gctgggctgg agctggagtg aaaccttcta 1298281 ccgcgcaatg gtgtttatgg ttgtcgcgtc accttgtgcg cttgtcgcct ctattatgcc 1298341 ggcggcgctg tccctgattt caaatggcgc ccgcaacggt atgcttgtga aaggaagcgt 1298401 ctttcttgaa cagctgggct cagtgcaaat gatcgccttt gataaaaccg gaactgtaac 1298461 aaaaggccag cctgccgtag agacgatcag aatagcagaa ggattcagtg aagcggaagt 1298521 tcttgaggct gtctatgcca tcgaaacgca atcaagccat ccgctcgccc aagccataac 1298581 ggcgtacgct gaaagccgcg gcgtgaatca gtccggctac atatctatag aagaaacctc 1298641 agggtttggc gttatggcag aagtgtcggg tgcgaaatgg aaggtcggta aagcaggttt 1298701 tatcggcgag gaaatggcag cacaatttat gaaacaaaca gcatcagatg tcattcaaag 1298761 cggtcataca attgtatttg tgaaaaagga tgatcaaata gcaggctgta tcgcactgaa 1298821 ggaccaaatc aggcctgaag caaaagaggt catggaagaa ctgaaccgac ttgggattaa 1298881 aacggccatg ctgacaggag atcacgaaga cacggctcaa gcgattgcca aggaagccgg 1298941 catgacaact gtcgtggcag aatgcctgcc tgaccaaaaa gtgaatgaaa tcaaacggtt 1299001 aaaagaagaa ttcggaacga ttgcaatggt gggtgacgga atcaatgatg cgccggcact 1299061 caaagcagcg gatgtcggca ttgcgatggg cggcggaaca gatgtagcac ttgagaccgc 1299121 tgatatggtc ctcatgaaaa acgatttgaa aaagctcgta aacatgtgcc gcttgtctcg 1299181 gaaaatgaac aggatcatca aacaaaatat cgtgttttct ctagctgtaa tctgcctgct 1299241 gatttgtgca aactttttgc aggcgatgga attgccattt ggcgtgattg gtcatgaggg 1299301 cagcacgatt ttagtcatac taaacggttt aagactccta aaataaaacc agcagcctaa 1299361 tcaggctgct ggctttttat gtatcaagct ttcccttcat ttttgtcttt atcagatctt 1299421 ttcataacta ggatgagagc gagggtgcag caaaggaaac ccgctgcaca gcctatgata 1299481 gagctgtaat aataaaagcc caccatcttc atcccgataa aaggagcgga aattcccaaa 1299541 accgttaaga gcataactgc ttttcgtctg aaaaaattca tcagcaaacg gaacaacccc 1299601 cctgcgattg aacgttactg tcagtataca ggaagaggag caggaaataa aatgcattag 1299661 aaaatgaagg cgtcgtgaaa ggcaaacacc ggtaaaacct gttacaatgg aagacagaac 1299721 aatgcattgc aaatggcagg gaggaacaag aagtgaatag aatacaacgc gtctcttcat 1299781 ggctgaagga agcggggcat actgccgcat ttattcatac gaaagaaaat gttttttact 1299841 taaccggttt ttacacagag ccgcatgaaa gattaatggg gttatttatt tttcaagaag 1299901 aggagccttt ctttgtttgt ccaggaatgg aagcaggaca ggcccgcaac gcaggctgga 1299961 atcatgaaat cattggctat gcggatcacg aaaatccgtg ggagctgata gagaaggctt 1300021 tgaaaaagcg aaatatcagc atacatatgc ttgcggtaga aaaggattca atctcgctgt 1300081 cacgtgcaga acagctgaag catgcgacgg gcggggctca atttgtttca gcagaagaaa 1300141 cactcaatca atttcgcctg attaaagatg acaatgagat tcgtttgctg aaagaggcgg 1300201 caaagcttgc agattacggt gttgaagtcg gcacagccgc tttgcgtgaa ggcatcagtg 1300261 aagtggaagt gctcgctcaa attgagtatg agctgaagaa aaaaggaatt cagggcatgt 1300321 ctttctctac aatggtttta ttcggagaaa aatctggcca gcctcatgga aatcctggta 1300381 cagccacgtt gaagaaaggt gattttgttt tatttgatct cggtgttatt cttgatggct 1300441 attgctctga tattacaaga acgtttgcat acaaaaccat caatccgaag caggaggcca 1300501 tttacgagac tgtgcttcaa gcggaaaaag ccgcgattga ggcaagcaaa cccggtgtga 1300561 gaatcggaga tctggattta actgcccgcg gaatcattga aaaagcggga tatggtgatt 1300621 attttcctca ccggcttggg catggactcg gaatttcagt ccatgagtat ccatcaatga 1300681 gccaggccaa cgatacactg ctgcaggaag gcatggtcta cacgatcgaa ccggggattt 1300741 atgtgccaga gatcggcggc gtacgcattg aggatgacgt tcacgtaaca aaggacggag 1300801 cagttgctct gacccaatat ccaaaggatt tgatcatact gtaatagaaa taaaaaagga 1300861 ctttgttctc gacatcgtcc ttttttatct gcattaaata aaaaaatcat caaatgttcg 1300921 aaagggttta atttcatgtt tttggttgag aggttttaca gcaagacagc tgccaccgag 1300981 aacagtgaga cataacccaa ttaaaatgaa gaaacccatg tgatcttctc ctttcagcta 1301041 aaaacacaaa aagatatctg gtacgtccat atcatattgt atgaaacgca ttccagatca 1301101 aggggattta gaaagaaggg aatctatggc taatattaaa gacattgcag agaaagccgg 1301161 tgtctctgtt acaacggttt cccgagtcat aaacaatcat ccatacgtca gtgaagacaa 1301221 acgaaaaaga gtgtttgagg caatggaatc attggagtac acgagaaata ttcacgctgt 1301281 acatttgtcg aaaggatttt caaacatgat tggtgttgtc ttgccgacgg ttaatctgcc 1301341 atattttgca gagctgattg caggaatagc cgacgcagcc gcggaatccg gggttcacct 1301401 ctctttattc caaacaaact atgaagtaca aaaagaaatc tttgcgctgt cccaattaaa 1301461 gcagcgccag gttgacggcc tgattttttg ctcaaaggcg cttgctgatg agaaactcat 1301521 ggaatgggag ggcccgattt tgctttgcca gaattcagat aatgcccgct tcccaaccat 1301581 cagcattcct caccaagaag catttcggaa cggcttggac tatttaattg ccaaagggca 1301641 caaaaaaata gccatctgtt tggcaagaaa aaaaggcatg aacagccatt ttcgaatcaa 1301701 agcctacaaa gaggcattgg aagagatcgg cgaggcattt cgtgaagact gggtaattga 1301761 gaaagcgatt acaatcaatg atgggaaggc gctttttcat aaatggaata cgtggaagga 1301821 aaagccgacg gctatttttg ttgccaatga ccaagtctca gcagggcttt ttcttgaagc 1301881 aaagaaccag cgggtgtcag taccggatga gcttgcaatc ttaagcgttg ataaccacga 1301941 aatcagccaa gcgcttggaa tcacaacgat cgatattcag acaagggaaa tgggaaagca 1302001 ggcatttgcc atattggaaa aaagaattca aggacagccg attgaaagga aagttctgga 1302061 ttaccgtctc atcgaaagat cgactgttta gtgaatgcat tgaaaaaagg tttgacgtgc 1302121 attctgttcg ttatgtacga tatgaggtat tgaatgacaa aggagctgag gatcgtgaat 1302181 gggtccttca cagtgaaaaa ggtactgaat aataacgtat taattgcttc tcatcataaa 1302241 tacagcgaag tcgttttaat cggaaaaggt attggtttcg gaaaaaaaca agatgatgtc 1302301 attgaagata aaggctacga taaaatgttc attttaaaag acgagaagga acaaaagcag 1302361 tttaaaaagc tccttgacta tgttgatgaa aagctcgttg atatttcaaa cgatgtcatc 1302421 tatcacataa gcaataggac gaatcactca ttaaatgaac atattcacat tgcgttgaca 1302481 gaccatatcg catttgcgat caaaaggcag cagcagggat ttgatatgaa aaatccattt 1302541 ctaatggaga ctcagtcact atatcctgag gagtaccaaa ttgccaaaga agtcatagat 1302601 atgatcaatg aaaaagcggg actctgcctt ccggaagggg agattggttt tatcgctctg 1302661 catatccatt cagcgttgac aaaccgtccg ctgtccgagg tcaatcagca ctctcagctc 1302721 atggcgcagc ttgtcgaggt gattgaagac tcatttcaaa tgaaagtaaa taaggaaagt 1302781 gtcaactatt tgcggctgat caggcatatc agatttacaa tagaaagaat taaaaaagaa 1302841 gaaccgacta aagaaccaga aaaattaatg ttgttattga aaaatgaata tccgctatgc 1302901 tacaatacag cttggaaatt gattaaaatc ttgcagcaaa cattgaagaa accagttcat 1302961 gaggcggaag cggtttatct gacgcttcat ctgtaccgat taaccaataa aatttcataa 1303021 attcagttta tccttataac gtgttactga ttcgatcagg catgagtgat tgagggaaaa 1303081 aaacgggaag ttcattctcg ttcttttgcg cacccaattt tgctcatgcc tttttgttgt 1303141 gtaaaagggc aaatgtaaac ggttaaactg gaagacttac gcctgtgaat tcgttgtcat 1303201 gatttttagc tgtaaggtca gactagtaaa aagaggaggt caattcttat gtttaaagca 1303261 ttattcggcg ttcttcaaaa aattgggcgt gcgcttatgc ttccagttgc gatccttccg 1303321 gctgcgggta ttttgcttgc gatcgggaat gcgatgcaaa ataaggacat gattcaggtc 1303381 ctgcatttct tgagcaatga caatgttcag cttgtagcag gtgtgatgga aagtgctggg 1303441 cagattgttt tcgataacct tccgcttctt ttcgcagtag gtgtagccat cgggcttgcc 1303501 aatggtgatg gagttgcagg gattgcagca attatcggtt atcttgtaat gaatgtatcc 1303561 atgagtgcgg ttcttcttgc aaacggaacc attccttcgg attcagttga aagagccaag 1303621 ttctttacgg aaaaccatcc tgcatatgta aacatgcttg gtatacctac cttggcgaca 1303681 ggggtgttcg gcggtattat cgtcggtgtg ttagctgcat tattgtttaa cagattttac 1303741 acaattgaac tgccgcaata ccttggtttc tttgcgggta aacgtttcgt tccaattgtt 1303801 acgtcaattt ctgcactgat tctgggtctt attatgttag tgatctggcc tccaatccag 1303861 catggattga atgccttttc aacaggatta gtggaagcga atccaaccct tgctgcattt 1303921 atcttcgggg tgattgaacg ttcgcttatc ccattcggat tgcaccatat tttctattca 1303981 ccgttctggt atgaattctt cagctataag agtgcagcag gagaaatcat ccgcggggat 1304041 cagcgtatct ttatggcgca gattaaagac ggcgtacagt taacggcagg tacgttcatg 1304101 acaggtaaat atccatttat gatgttcggt ctgcctgctg cggcgcttgc catttatcat 1304161 gaagcaaaac cgcaaaacaa aaaactcgtt gcaggtatta tgggttcagc ggccttgaca 1304221 tctttcttaa cggggatcac agagccattg gaattttctt tcttattcgt tgctccagtc 1304281 ctgtttgcga ttcactgttt gtttgcggga ctttcattca tggtcatgca gctgttgaat 1304341 gttaagattg gtatgacatt ctccggcggt ttaattgact acttcctatt cggtatttta 1304401 ccaaaccgga cggcatggtg gcttgtcatc cctgtcggct tagggttagc ggtcatttac 1304461 tactttggat tccgatttgc catccgcaaa tttaatctga aaacacctgg acgcgaggat 1304521 gctgcggaag aaacagcagc acctgggaaa acaggtgaag caggagatct tccttatgag 1304581 attctgcagg caatgggtga ccaggaaaac atcaaacacc ttgatgcttg tatcactcgt 1304641 ctgcgtgtga ctgtaaacga tcagaaaaag gttgataaag accgtctgaa acagcttggc 1304701 gcttccggag tgctggaagt cggcaacaac attcaggcta ttttcggacc gcgttctgac 1304761 gggttaaaaa cacaaatgca agacattatt gcgggacgca agcctagacc tgagccgaaa 1304821 acatctgctc aagaggaagt aggccagcag gttgaggaag tgattgcaga accgctgcaa 1304881 aatgaaatcg gcgaggaagt tttcgtttct ccgattaccg gggaaattca cccaattacg 1304941 gatgttcctg accaagtctt ctcagggaaa atgatgggtg acggttttgc gattctccct 1305001 tctgaaggaa ttgtcgtatc accggttcgc ggaaaaattc tcaatgtgtt cccgacaaaa 1305061 catgcgatcg gcctgcaatc cgacggcgga agagaaattt taatccactt tggtattgat 1305121 accgtcagcc tgaagggcga aggatttacg tctttcgtat cagaaggaga ccgcgttgag 1305181 cctggacaaa aacttcttga agttgatctg gatgcagtca aaccgaatgt accatctctc 1305241 atgacaccga ttgtatttac aaaccttgct gaaggagaaa cagtcagcat taaagcaagc 1305301 ggttcagtca acagagaaca agaagatatt gtgaagattg aaaaataagg gtgttagtac 1305361 gccgtgcttg tcagatgaca agtacggttg tatgatataa tattgtgaag taataaagct 1305421 ttaagttaaa aggagaatga taaaaatggc acaaaaaaca tttaaagtaa ctgcagattc 1305481 tggaatccat gctcgtcctg cgacagttct tgtacaaact gctagcaaat acgacgctga 1305541 cgttaattta gaatataacg gcaaaacagt taaccttaaa tctattatgg gtgttatgtc 1305601 tttaggtatc gctaaaggcg ctgagatcac aatctctgct tccggagctg acgaaaacga 1305661 tgctcttaac gctttagaag aaacaatgaa aagcgaagga ctcggcgagt aatgcaagaa 1305721 ttaaaaggga ttggtgcttc agccggcatc gcgattgcaa aagcgtaccg gcttgaagag 1305781 ccagatttaa cggttgaaaa gaaaaacatc tctgattctg aagcggaagt aagccgtttt 1305841 gatgaagcga ttgcacgttc aaaagaagag ctcgaaaaaa tcaaagagca cgctttgaaa 1305901 gaactgggtc aggataaagc tgatattttt tctgctcacc ttttagttct cagtgaccct 1305961 gagcttctga accctgtgaa agaaaaaatc agcactgatt cagtgaacgc tgaattcgct 1306021 ttaaaagaaa cgtcttctat gttcgttact atgtttgaat ctatggacaa cgaatatatg 1306081 aaagagcgtg cggcagatat ccgcgatgta acaaaacgcg taaccggcca cctgcttggc 1306141 gtcgaaattc caaacccaag catgatctca gaagaggtta ttattgtagc tgaagactta 1306201 acaccgtctg acacagctca attaaaccgt gagttcgtaa aaggattcac tactgatatc 1306261 ggcggacgca catctcactc tgccatcatg gcacgttctc ttgagattcc agcagttgtt 1306321 ggaacgaaag ctgctacagg cacgatccaa aacggcgtga ctgttatcgt tgacggtatc 1306381 aatggcgatg tcattattga cccatctgcg gaaactgtaa aagagtatga agaaaaacat 1306441 aatgcttatt tggctcaaaa agctgagtgg gcgaagcttg tcaatgaacc gactgtctca 1306501 aaagacggac atcatgtaga gcttgcagcg aacatcggta ctcctgatga tgtaaaaggt 1306561 gttcttgaaa acggcggaga agcagttggc ctttaccgta cagaattcct ttacatggga 1306621 agagatcagc tgcctacaga agatgagcag tttgatgctt acaaaacggt tcttgagcgt 1306681 atggaaggaa aatcagtcgt cgtgcggaca cttgatatcg gcggagacaa agagcttcct 1306741 tacctgcagc ttcctaaaga aatgaacccg ttcctgggat atagagcgat tcgtctttgc 1306801 cttgaagagc aagaaatctt cagaacacag cttcgcgcgc tgcttcgtgc aagtacatac 1306861 ggaaacttga aaatcatgtt ccctatgatt gcgacagtta acgaattcaa agaagcaaaa 1306921 gcgatccttc ttgaagagaa agaaaagctc gtaaaagcgg gacaggctgt atctgacgat 1306981 attgaagtcg gaatgatggt tgagattccg tcaactgcag tcatcgctga tcagtttgct 1307041 aaagaggttg atttcttcag tatcggaaca aacgatttga ttcaatacac aatggcagct 1307101 gaccgtatga atgaacgtgt atcttacctg tatcagccat acaacccggc aatccttcgc 1307161 ttaattacac tggtaattga agcagcacac aaagaaggaa aatgggttgg catgtgcgga 1307221 gaaatggcag gagacgagat tgcgattccg atccttctcg gcttaggctt agatgagttc 1307281 tcaatgagcg caacgtctat ccttccggca agaacacaaa tcagcaaatt gtctaaacaa 1307341 gaagctgagt cattcaaaga gaaaatctta tctatgagca cgacagaaga agttgtcgcg 1307401 ttcgtaaaag aaacattcaa gtaatgtaca aaaaccagac ggcctccggc ctgtctggtt 1307461 tttttcataa gtaagggtat agaaggacac aataacatgg ctaggaggga tagtatgtca 1307521 aaccaattta acgcaggaga tactgtttat gtgatctaca gaaatccgca cgccgccaat 1307581 gtagcccaca taaaggaagc cgaaattgtg caccatccat accatgaagg cgagctttcc 1307641 ctgtttattt atgaaaccta tcatccattc gcagaggacg atgctgtgtt tgcaagctat 1307701 gaagaagcta aatcgcttta caaagaactg tttgatattg atccgtatga gtaacaagga 1307761 aatcattaca actcatatcc tttccgccta gtgagaaaag taacgttagt aaaggaaaag 1307821 gatgtggcat catgcagaac ccatttgttc cgcagcttgt gtatatagaa ccgagggcgc 1307881 tggaatatcc gctgggccaa gaattacaag ataaatttga gaatatgggt attgaaatca 1307941 gagaaacgac atcccacaat caggtgcgta atatccctgg gaaaaatcat cttcagcaat 1308001 atcgcaatgc gaaatcaact ttagttatcg gtgtccggaa aacattaaag tttgattcat 1308061 ccaaaccctc ggccgaatat gccattccgt ttgcaacagg ctgcatgggg cattgtcatt 1308121 actgctacct gcaaacaacc atgggatcaa agccgtatat cagaacttat gtaaacgtcg 1308181 aagagatttt agatcaggca gataagtata tgaaggagcg cgcaccagag ttcacaaggt 1308241 tcgaagcatc atgtacgtca gacattgtag gaattgatca tctgacacac acgctgaagc 1308301 gcgccattga acattttggc caaagtgatc tcggaaagct ccgatttgta acgaaatttc 1308361 atcatgtcga tcacctatta gacgcaaagc ataacgggaa aacgagattc agattcagta 1308421 ttaatgccga ctatgtgatt aaaaactttg agccgggaac ttcacctctt gataagcgga 1308481 tagaagcggc agtaaaagtt gcaaaagcag gctacccgct aggctttatt gttgctccga 1308541 tttatattca tgaaggctgg gaagaaggat acagacatct gtttgaaaag ctagatgctg 1308601 ctttgccgca ggacgttaga catgacatta cgtttgaatt aattcaacac cgttttacaa 1308661 aaccggccaa acgagtgata gagaaaaatt atccgaagac gaagctcgaa ttagatgaag 1308721 aaaagcgccg ttataaatgg ggccgttacg ggatcggaaa atatatttat cagaaagatg 1308781 aagagcatgc acttcgagag gcacttgaat cctatattga tacctttttc cctaacgcaa 1308841 aaattgaata tttcacttaa acgggctgtt gtgatcaaca gctcgctttt ttataaaaaa 1308901 catttttcca ttccatcaaa acgccgtaat tcaatgattc tttatcctcc aaataattgc 1308961 tgactacacg aataggtgaa cgcccgcaac ggaggagaaa ggacagcaca gggtcgtttt 1309021 tcctgccttc catcacatct tcaacgtact gaacagcgct gatctcgtgt gcgtatttat 1309081 aatacaaagg aatgcggccg ccgccgagaa ggcgttccag tcttttatca acagtcagct 1309141 catacatcgt attcatcagc cattttccga ttccaagctt tcgataatga ggagaaacag 1309201 aaatatccac tacatataaa gtatttccat gaggttcatg atttttaatc gatccgttgt 1309261 cagttgcttg tgcccatgta tgatcaggag aatcaggctc aaattgtaca ataagagcag 1309321 tcatggaacc gataattctg ccattgatga gcgcgcataa agcgccttcc ggaaaggttt 1309381 tgatatggct ggcaagctgg tcctctgacc acagcaattc ctggggaaac ggaggaggga 1309441 aacattcttc ttgaagagaa atcagcctct cgatgtcagt ctcagtgtag tttctaatgg 1309501 tcagagcctc aaattttctg ccgtcatgca catacatttg ttttagtatg atcatcactc 1309561 tccttatgtt gtttcattat aacgaagatt gaattttcag taaatatatt ccgattttct 1309621 tataatttat tttttgatta ttcatttttc aaacgaaagg gccgatatag aaattaggag 1309681 gggattggtt tgtttaaaaa acttcacatg aagattgctg tttttgtttc gattatgtta 1309741 atcatcacag ttgttctctt aatgctgtct tcttatttga cgctaaaacc gatgattaca 1309801 gaggatggga aaaatacaac tcaaaacgtg acgcagtcac ttgaacaaaa tattgaattg 1309861 caattaaaga gttatgccat ttcgttatca agattggcta atggggaatt aacgcataca 1309921 tttgtaacga aaccaagtaa agaagcttct cggctgtttc acgatgacat taagcaaatc 1309981 aaagacaacg atgattatgt tgcgatggct tacataggca ccgcaaaaaa agaaatgttt 1310041 acatatccaa aagcggattt cgctgaggat tacgatccaa catcaagacc atggtataag 1310101 cttgcagctg aaaccccgga tcaagttgtt tggacggaac cttataaaga tgtcgtgaca 1310161 ggagacatga ttgttactgc atcgaaagcg atcttagaca ggcaaaaagt gataggggtt 1310221 gccagctatg acttgaaact ctctgctatc cagagtatgg tcaataaaca aaaggtgcct 1310281 tacaaaggat ttgccttttt agctgatgcg agcggcaatc ttttagccca tccgtcaaat 1310341 caaggaaaaa atatatcaaa ggatcaaaca ctgcaaacca tcgcatccga gaaaaaaggg 1310401 atacaagatg tgaatgggaa aatggttgtg taccaaacga ttggcgagac aggctggaag 1310461 gtcggaacgc aatttgatac cgatcaatta atgtggattt cagataaaat gaatcgggcc 1310521 aatctttgga tatcattgat tgcgcttatc ataacaatta ttctcagcta cttcctggcc 1310581 aaaacgataa ccggtccgat acagcagctg atcgtaaaaa cgaaagctgt ttccgcaggc 1310641 gatttaacag tgcgcgcgga atcaaaatct aaggatgaag tcggtatttt aacaagagat 1310701 ttcaatctga tggttgaaaa tatgaaggaa atggttgagc aagtgagact ctcttcaggg 1310761 aaagtatctg acacctctga acaactaacg gctgtggctg ccgaaactaa tgaaacaagc 1310821 ggacaaattg caaaagcgat tgaagaagta gccgcagggg catcggaaca ggcttctgaa 1310881 gttgaaacca ttaatgaaaa atcggaaagc ctgtcaacga aaatcaggca aatcgctgag 1310941 gaggcaggcg gaattaaaga acgctcaaaa tcgtccgagg atgcaagcta taaaggactt 1311001 gacgcgctcg gccagctgct gatgaaatca aacgaagcca atatggaaac gaaaaaggtt 1311061 gaaacgatgc tgctggattt ggaaaatcaa actaagaata ttgaagaagt cgttacagcg 1311121 atttcaaaca tatctgatca aaccaacttg cttgccttaa atgccagtat tgaggcagcc 1311181 agagccggag aaagcgggcg cggttttgcc gtcgtagccg atgaagtgcg gaagttagct 1311241 gagcaatcag ccctttctac aaagcatatc agcgagactg tgaagcttat ccagcttgag 1311301 acaaaagagg cctctcacgc gatggttgag gcaagcagaa tgaatgatga acaaaacagt 1311361 gcaattcacg aaactggaga ggtattaaat acgataactg cagaaatgca gtcactggta 1311421 caaggtattg atcacattta cgcggaaatt caaagaatga gtgaagaaca gcttgcgatt 1311481 tctgaagcca ttcaaagcat ttcagccata tcacaggaat cagctgccgc agcagaggaa 1311541 gtgaacgcat caaccgatga acagcttgtc acccttgata aagtcaaaca ctcaacggaa 1311601 acactaaaac atgcaagcca agagcttatg aacacaattg caaaattcac attgtaatcc 1311661 aattacatcc ccaaacatca tttgttttgg ggatttttta ttttataaga tgaatagata 1311721 tggtagtcta gaaaatgaag gaaaaatgat aaattttaac taaaatctaa acgaaacatc 1311781 tgggaggaat gaccttgaaa aaaacaattg gttttatcgg tcttggagta atgggaaaaa 1311841 gcatggcatc acatattctc aatgacggcc atcctgtatt ggtgtacacc cggacaaaag 1311901 aaaaagcaga aagcatactt caaaaaggcg cgatctggaa agatacggtc aaagatcttt 1311961 cgaaagaagc ggatgttatc atcacaatgg tcggctatcc cagtgatgtt gaagaagtgt 1312021 atttcggaag caatggaatt attgaaaacg caaaagaagg tgcatatctt attgatatga 1312081 cgacatctaa gccttcgctt gcgaagaaga ttgctgaagc ggccaaagaa aaagcattgt 1312141 tcgctttaga cgctcctgtt tccggtggag acatcggtgc acaaaacgga acactcgcga 1312201 ttatggtcgg tggagaaaaa gaagcttttg aagcctgcat gccgattttc tctttaatgg 1312261 gagagaatat tcagtatcaa ggaccggctg gaagcggaca gcataccaag atgtgcaatc 1312321 agattgcaat tgcagccggt atgatcggtg ttgctgaagc gatggcttat gcccaaaaat 1312381 caggcctaga gccggaaaat gttctgaaaa gcatcacaac gggcgcagcc ggaagctggt 1312441 cattgtcaaa tcttgctccc cgtatgctgc aaggcaactt tgaaccggga ttttatgtga 1312501 agcattttat taaggatatg ggaattgcac tagaggaagc agaattaatg ggggaagaaa 1312561 tgccaggctt gtcgctcgca aaatctttat atgacaagct agctgctcaa ggtgaagaaa 1312621 acagcggaac acagagtata tataagcttt gggtgaaata aaaaaagatt gcctgtacga 1312681 aacaggcaat ctttttttat tattttccga tgaattgttg tgtccagatg cttccagact 1312741 caacgtaacc aacaccgatg tgagtaaagt tagggtttag aatgtttttt ctgtgtcctt 1312801 cactgttcat ccaagctttt actacttctt ctggtgtctt ttggcccttc gcaatgtttt 1312861 cacctgctgt tttgtagctg attccgaaag atttcatcat atcaaacggt gagccgtatg 1312921 ttgggctttg gtgatcaaag tagtttttgt ctttcatatc ctgagatttt gcgcgtgcag 1312981 atttgcttaa cgtttcatca atttgaagcg gttttaagcc ttgtttttgt ctttctgcat 1313041 ttgtaagttc aacaactttt ttctcatatg cacttacaga tgaaggtgca gacgttgttg 1313101 tgtttgtttt ttcagcagtt gcgggtgctt tagaagcagt gttttgatca gcagctgctt 1313161 tttcagtagt cttttgtgca ggttttgccg tttctgtctt ttgaacatcc tgaactttca 1313221 cgttagattg cttcgcatgt ttttgaagaa gctgcttcat ctctttttcg tttgcagcgt 1313281 ttaacgtttt gatatttgtg ttaatatgca gttttttcac tgcatcgtta agtgacatgt 1313341 tttgtactgt gttccccgtt tttactgtaa ccacaggctg gcaggagagt tctttcgctg 1313401 atgcttgctg tacgcccccg aatgtgaata atccaaccgc agcggcagca gataaaataa 1313461 atgctttctt cattagttcg taacctccta gagttgtttg tttctacaga aaaatcataa 1313521 catagctttt ttgtcataaa gattccagca ctttcctttg acaaatagag attgtcattt 1313581 tcgtaaagta aatccgttga atcactaaga ataagggaat cagcggtata tatgatttta 1313641 tcgtaccgtt acatagcttc cttttttttg aaccgttagt tatattttaa tgtgttttta 1313701 tattgacagc tttttttact ccttttcgct gtaacaacta ttacaaaggt gttacaatta 1313761 atctcagtat atgtaaatat attgaatgat ttgagagggg taaccagaag tgactgaaat 1313821 aggacgtgaa ccaaagaaaa agagcaaagg aaacagagca atcagaatga accttttttt 1313881 cctagctgtc tttgttctat tcactgcatt aatttttaag ctcggggttg ttcaaattgt 1313941 tgaaggcgaa cagcatgaag aagacgctga gaaatcaaat gcaaaaacag cttactatcc 1314001 tgcgcctcgc gggaagatgt acgacagaaa ccagaaagtt gctgtcgaca accagagcgt 1314061 tccagaaatt gtgtatgtat caacatctag cacaaaaaca gaagataaaa tcaaaacagc 1314121 gaagcggctt gcttctttca ttcatattga taccgaattt ttgaaggaaa gggatcttcg 1314181 tgattactgg atcgcagctc atccgaaaaa agccgccgct ctgcttaagg aatcagaaag 1314241 caatctgaaa ggagaccagg cttacaagct tcaaatagag cgtgttccgg atcaagaatt 1314301 aaaggctatt cagcaagatg acgaagaaat ggaaactgct gcgatatata caaggttttc 1314361 aagcggaaat gcttacgaac ctcaaatcgt aaaggcaatg aatccaaata agagcaatag 1314421 caatggaaaa aacggagcgc tgcttgatga gaagaaaaac tcctcgcaaa gaccaaaaaa 1314481 tgacttaaca tatgatgaaa tttccattgt ttctgagcat ttagaagaac ttccgggaat 1314541 cgatatcgta aacgattgga cacgaaaata tccttatgac aaaacccttt attctgtttt 1314601 cgggggcgtc acgacacctg atcagggcct gctgagcgac cggaaagatt tctacttaac 1314661 aagaggctat gcgaataatg acagggtggg aaaaagttat ttagagtatc aatatgaaga 1314721 atatttaaat tcgcataaag aaaaagtgga atacgtagaa gataataaag gaaatgtcgt 1314781 cagccaaaaa accattgata agggcagcag gggatacgat cttcagcttt cttttgacat 1314841 ggagcttcag gcaaaggtag aaaagatcat tgaagaagaa gtaagaaaca gccgtgcacg 1314901 cggaaattac atgcttgaca gagcctttgc cgtaatgatg gacccgaata acggcgatat 1314961 tttatcaatg gcagggaaaa agatagattt aaaaaccaac aaaattgaag attatgcgat 1315021 aggggcattt accacccaat atgaaatggg atcagcagta aagggggcca ccgtgctagc 1315081 cggctatcag gacgggatcc cgcattataa atattatatc gatgctccaa tgcttttagg 1315141 aacgaatctt ataaaaaaat cttatactaa tatgggaacc atcaatgaat taaccgcatt 1315201 gcaaaaaagt tcaaacgtat atatgttcaa tgttgccatg catattgcag gcgtaacata 1315261 caagccgcat ggatctctcc cggctgatca gaacgatcta ctgaaaatga gaaactatta 1315321 cagccagttt ggtctgggag taaagacagg tattgatctc ccgcaggaat cagccggaat 1315381 gcaaaccaca cctaaaactg taggaggatt aattttagac ttagcaattg gccaatacga 1315441 tacatacaca ccgcttcaaa tggctcaata catctcagta atcgccaatg gtggctatcg 1315501 tgttcagcct agaatcgtca caagtattca taagccagga aaaaaagacc agctgggtaa 1315561 ggcgattgaa cataggaaac ctaaagtact caataagatt aataattcag agagcgattt 1315621 gaaacaagta caaacaggca tgaaattagt cacttcttca gggacagcaa aaaatacgtt 1315681 tacagaagat gtatcaggga aaacgggaac agcggaaaca ttttactacg gcacgaatcg 1315741 caactggtgg gggaaaaaaa catacaatct gacttttgtc ggctattacc cgtcgaaaaa 1315801 accaaaagtg gcctttagtg ttgttgttcc atcagtagat gatgatgata agatcaataa 1315861 aattattgcc aaaagagcta tccacgccta cgcagagctc gaaaaaaaac acagtaaaaa 1315921 ataaaaaaca gggtgcacaa ctaaaagatt gtgtgccctt tcttttattc aaaaattgac 1315981 gttcaccata agaatagaag gagaatactc attttctagc gaatcatact aggtaaaagt 1316041 caatctgtat atgtcgaaac acgatgatca tgcaaaggag ggattctgtg gaacaggata 1316101 cgcagcatgt taaaccactt caaacaaaaa ccgatattca tgcagtcttg gcctctaatg 1316161 gacgcatcat ttatatatct gccaactcca aactgcattt gggctatctc caaggagaga 1316221 tgatcggatc attcctcaaa acgtttctgc atgaggaaga ccaatttttg gttgaaagct 1316281 atttttataa tgaacatcat ctgatgccgt gcacctttcg ttttattaaa aaagatcata 1316341 cgattgtgtg ggtggaggct gcggtagaaa ttgttacgac aagagctgag cggacagaac 1316401 gggaaatcat tttgaaaatg aaggttcttg aagaagaaac aggccatcaa tccctaaact 1316461 gcgaaaaaca tgaaatcgaa cctgcaagcc cggaatcgac tacatatata acggatgatt 1316521 atgaacggtt ggttgaaaat ctcccgagtc cgctatgcat cagtgtcaaa ggcaagatcg 1316581 tctatgtaaa cagcgcgatg ctttcaatgc tgggagccaa aagcaaggat gctattattg 1316641 gtaaatcgtc ctatgaattt attgaagaag aatatcatga tatcgtgaaa aacaggatta 1316701 tacgaatgca aaaaggaatg gaagtcggaa tgattgaaca gacgtggaaa aggcttgatg 1316761 gcacacctgt tcatttagaa gtgaaagcat ccccgaccgt ctacaaaaac cagcaggctg 1316821 agctgctgct gctgatcgat atctcttcaa ggaaaaaatt ccaaaccatc ctgcaaaaaa 1316881 gccgtgaacg atatcagctg ctgattcaaa attccattga taccattgcg gtgattcaca 1316941 atggaaaatg ggtatttatg aatgaatcgg gaatttccct gtttgaagcg gctacatatg 1317001 aggatttaat tggcaaaaac atatacgatc agctgcatcc ttgcgatcac gaggatgtaa 1317061 aagagagaat ccaaaacatt gccgagcaaa aaacagaatc tgaaattgtc aagcaatcct 1317121 ggttcacctt tcagaacagg gtcatctata cggagatggt ctgcattccg acgacctttt 1317181 ttggtgaagc ggccgtccag gtcattcttc gggacatctc agagagaaaa caaacagaag 1317241 aattgatgct gaaatcggaa aaattatcaa tcgcagggca gctcgcggcg ggaatcgccc 1317301 atgagatccg caaccctctt acagcgatca aaggattttt acagctgatg aaaccgacaa 1317361 tggaaggcaa cgaacattac tttgatattg tgttttctga actcagccgt atcgaattaa 1317421 tactcagtga actgctcatg ctggcgaaac ctcagcaaaa tgctgtcaaa gaatatttga 1317481 acttgaaaaa attaattggt gaggtttcag ccctgttaga aacgcaggcg aatttaaatg 1317541 gcatttttat cagaacaagt tatgaaaaag acagcattta tataaacggg gatcaaaacc 1317601 aattaaagca ggtattcatt aatttaatca aaaatgcagt tgaatcaatg cctgatgggg 1317661 gaacagtaga cattatcata accgaagatg agcattctgt tcatgttact gtcaaagacg 1317721 aaggggaagg tatacctgaa aaggtactaa accggattgg agagccattt ttaacaacaa 1317781 aagaaaaagg tacggggctt ggattaatgg tgacatttaa tatcattgaa aaccatcagg 1317841 gagttataca tgtggacagc catcctgaaa aaggcacagc gtttaaaatt tcatttccaa 1317901 aaaaataaaa acaacggctt aaacgccgtt gtttatcgtc tgcattgctt cacgtttttt 1317961 taatacaaat aattctaaac ggtctaggcc ttctctcagc gtgtccattg agcatgcaaa 1318021 agacagcctt acatatcctt caccatatgt tgagaacgag ctgcccggca cgagtgccac 1318081 gccagcgtct tccaaaagag ccatactaaa atcaaatgaa gtcattccaa atgatttaat 1318141 agaagggaag atataaaacg caccggacgg tttaactacg tcaagtccca tggaaacaag 1318201 acggtcataa acatagtcca gacgtttttt gtattgttct ctcataatca atgcatcgtc 1318261 aaagccgttt gtgacagctt caagcgcggc tttttgagaa atggatgagg cgcacgacac 1318321 attgtattga tgaaccttta aaatgtgctt tgcaatgtct ttcggtgcaa ataaaaatcc 1318381 aattctccaa ccggtcatgc tgtgtgattt tgacaacccg ttaatgacaa tcgtttgatc 1318441 ccgcaaatag gttgcgatgg agtaatgcgg tctgtcatat gttaattcac tgtatatttc 1318501 atcagacaat acgaagacat ttctgccttt taagagagct gcgatgcttt tcagttcttc 1318561 ttcagataaa gtcacgccgg tagggtttga cggataagga agcacgacac acttggtgtt 1318621 gggtgtcaga gcatcttcaa tcagccgggc ggtaagctta aagccgtgtg acgtagtatc 1318681 aacaatgaca ggcttggccc cgcacaaatt gataataggt tcatagcccg gataaatagg 1318741 ccctggcata atgacttcat caccgggaga taaaatcgtc cggaatgcag catcaatggc 1318801 ttggcttgcg cctgttgtga tgataatttc agattcagca tcatagttga aatccgcttt 1318861 tttcttcata taaagctgca cagcttgtct cagctccagg tagccggcat tcggagtata 1318921 tgacgtcacg ttttcatcaa tggctttttt tgcggcagct ttcacatgat gcggtgtgaa 1318981 aaaatcaggc tggccgattg taagtgaaat gacgtcttcg tgttgggcta caagattcga 1319041 gaatttgcgt attcctgaaa tttcgatctc tcttgctttc ggattcagca aatgttccat 1319101 aattcatcac cttaacaaat ataatgagtt tatcctattt taccactagc tgatcatttg 1319161 tcaccttttt aactgatata tttcgattgt atgcgccttt tttctaaaca tacctttctt 1319221 ttcagaaaaa aagaagacaa ccagcgattt gattgtcttt attgtatcat gttctattat 1319281 tgtttatatg tgccaatttc attaatagcc ataatcaaaa tgaaggtctt cgtgccaaat 1319341 cagatacgga ggatgctctt cttgaaggtc agctgattct ttcttcatat tcaggtaagt 1319401 ttcttcactg atatcctcta aaacagtcat ttcgttttct ttaaatatta ctaaggtacc 1319461 cattatttac acccttcttt ggaaaaatcc ttgactattt tatcactgtt agttggaaag 1319521 tcaatggtta ttaggaaaaa agtttctttt ttgaggaacg cggcttgttg ccttcggaat 1319581 tcgattttga agagctgcca ttcacttttt acaaattacg ccgatatata cagtacaata 1319641 ctgaatgcga atagcgaggg attgaattgt cgttacaaca atacgaaatt ttattggatt 1319701 ctggtacaaa tgaattagaa attgtgaagt ttggcgtggg tgaaaatgct ttcggaatta 1319761 acgtcatgaa ggtaagagaa attattcagc ctgtcgaggt gacatcagtg cctcactccc 1319821 atcagcatgt agaaggaatg attaaactca gaggagaaat cctccctgtg atcagtctct 1319881 tctcattttt tggagtagag cctgaaggat caaaagatga gaaatatatc gtgactgaat 1319941 ttaataaacg gaaaattgtt tttcatgtcg gctctgtttc tcaaattcac agagtatcct 1320001 gggaagcgat tgaaaagccg acatcgttaa atcaaggaat ggagcggcac cttaccggta 1320061 ttattaagct cgaagacctg atgatctttt tgcctgacta tgaaaaaatt atttatgaca 1320121 ttgaatcaga ttcaggtgtt gacacgtata atatgcatac cgagggcttc gatgaaagaa 1320181 gaactgataa aaagcttatc attgtagagg actcaccgct tttgatgcgc ctcttgcagg 1320241 atgaattaaa agaagcaggg tacaacaata tcgcttcgtt tgaaaatgga aaagaggcat 1320301 atgaatacat tatgaacctt gctgaaaacg aaactgattt atcaaaacag attgatatga 1320361 tcatcactga tattgaaatg ccaaaaatgg acggacacag gctcacaaag ctgctgaagg 1320421 aaaatccgaa aagctcagat gtgccggtta tgattttctc atcgttaatt acggatgatc 1320481 tgcgtcaccg cggcgaagtt gtaggcgcag atgagcaaat cagcaagcct gagatcagtg 1320541 atttgattaa aaaagtggat acgtatgtta ttgaataaat aaaaacagcc gttgccagaa 1320601 agaggcacgg ctgtttttat tttaaaagta actctcgcca agttttttaa agaccggttt 1320661 atggtaagct ggctgctggc gatttggcac tagcggcttt tctttcatgc cgacatattc 1320721 ttgcaatagg tgtttcgctt ttgttaaaga catttgagct ttaggatttc gatacgattg 1320781 attaagtgta cctaaatgcg gaagatgttc gaagtcttct ttagttggag gcatgtgaaa 1320841 atagtagtct ccgattgaga taagcacgtc cgattgctgt tggctgaacc ttggattttt 1320901 tgaaaaatga agccctattt tctttccttt accttctttg acaagctttt gcaaagcccg 1320961 ttttttcagc agatataggt atttagggtt gggggcggtt tttgcatggc ggttcacagt 1321021 gtaaactgct tttgaaagat tttctacggt tggctgcaga tctttcgtat atgcatggtc 1321081 gtccattatt tctctccttt gctcttatca atttctatat gtttagatta tactttttta 1321141 aagttgaaat gcaaatattg aatgtaaaaa tgcgcttttt tctaagaaaa aaagcgcatt 1321201 tttaacctgc attatacaga tcttgccttc tttttcggct gttcttgaaa tgcttcctga 1321261 acattcactt ccacagcctg agcactgtat tttggcagtg caataaaata aaaaataaaa 1321321 acgagcagga taataacacc catgccgtaa taaagataat caatgtttga aacaaactta 1321381 gggaataaca gcgcgactaa gccgagtgtc aaagattgtg caaacatcat aaaagggtcc 1321441 tgcatgccgc ttacacgtcc catcagtttt ggatgaacaa tttttggcat ccaccctccg 1321501 attgcaatgt tgatcggtcc gatacacatt cccagtgcaa aagctgccgc gtaatacacc 1321561 cataaaatat tggtgtagcc gaggacgaag atcagcaaac ctgcaatgaa aatcggtatc 1321621 gacattaaaa agtgcggctt cactttttta gagatgagcg tgccgattac gcttcctgcc 1321681 agaagcccaa acccgagtgc gatcgtaaat acagacgtat gccactcata acggtcaggc 1321741 gccaatccat atttcattgt aaacatcggc aatacggcga atcctccatt gacaaatcca 1321801 aaaatgaaga agccaaaaat aagagatgcc agcaatttgt tttttaaaat atagaggatg 1321861 ccttctctaa agtcatttat tgaatcctta acagaagtct ttctccagct gaatgcaccg 1321921 tttggctgtc gggcttcttt tggaatccgg cagctgcgga tcagcagccc ggaaatgata 1321981 aagctgacaa aatcaagaat aatggcgcct tcaataccga ttgtgttgta cataaacgcg 1322041 cctatgccga ctccaaacac cataaaaatg ctaaaaagca tctgattaag ccctgccgct 1322101 ttcgcataat gctccttcgg cagaatggct tgtaccaaac tgttttctgc cggaaagaaa 1322161 aactttgtta cagcgcttct gataaataag atacaaaaaa caagaggaat attgccggta 1322221 aataaagtga aaaaaagcac gacagtcagg cctgctctga tccaatcaca attttctgcc 1322281 accttttttc tatcaaaccg gtccgcgacg actcccacga tcagaaatac aaatatggtc 1322341 ggaagagaat acatcagctc cgccaaggtc gtatatgaag gctggctgct gaatcggtcc 1322401 agcaaaaaaa aagcaaaggc catgttgcct actgtcgtgc ccatttgaga agcgagtgct 1322461 gcgaaaaata gacgaacaaa attacgattt ttaaatatat ccataaaaac gctccttacc 1322521 ctaaaggtcc cactttatca tattataaac cgcctgtttt tgaaacaaat aagaaaacat 1322581 taccggttaa tcgtgactct cgttccgttt ggcacaattg aagcaagttc gatcacgtct 1322641 ttgttatgca tgcgaatgca gcctttagaa acagccttac caatcgaagc gggattattc 1322701 gtcccatgta ttccgtagtg ctgctttgaa aggctcagcc aataagcgcc aaatgggccg 1322761 ccgggattgc gctggcggtt aataatgtaa aactcgccag taggcgtttg cgttagtatt 1322821 ttaccaacgg cgatgggata ggttttcatt acccgattat ttagggacag cgtaagggtc 1322881 ttcgctccga ttgagactgc gatatgatac ggaattgtat aagggtccgg cagtccgggg 1322941 atgactatgg actgtcccgc ggtgagccct gcctgcagtg acggattagc ctggagtaat 1323001 gcagccgtgc tgattctgaa atcagccgcg atgctgttca gtgtatcacc ttgcttcacc 1323061 tggtacgtaa gcagtttcct catcctcctt ttttacttat aagtattgat gaggagccca 1323121 tcctgctaca ttaatttgtg ctttttaagg tgaagacagt gatttcaggc ttggcaagaa 1323181 accgcaaagg cagcctggtc atcccgaggc ctcggtttac gtaaatatga gtgctgcccg 1323241 tttgatacat tccctctgtg tagacttttc catatggagg cgtaataatc ggtccgtaaa 1323301 aaggcagctg aatctggccg ccgtgtgtat ggccggaaag ctgaaggttc acgggataat 1323361 ctgttgtttt caaggctgca tcaggttcat ggacgagaag aatggaaaaa agtctgtcgc 1323421 tcagccttga aagggtgcct tcataatctg ggtttcccag cattaagtca tcaagcgaag 1323481 caatctcgat tttgctgcca tctgcgagtg acaatgtttg atagccattg cgatataccg 1323541 tgaaacctcc ggccgtcatc aggcttttgt aaacggcagt tccatagcct ccgtgatcat 1323601 gattgccgta aatacaaagc ttgccgaagg gagcattaag ctttctcaat aatggaatga 1323661 ctgcctggtg gtgctggtac gtatcaggat tatcaataat atcacctgta aaaacaatga 1323721 gatcaggttt agattcatta attgtaagaa tgacagtttt taaatcttcg agagtaaagt 1323781 aatcactcaa gtgtgcatcg ctgaactgca cgattttaaa accgtcaaat ccgtgcggga 1323841 tgagagagct ttttattgtg tgttcggttg tctcgatcat atgcggctcg agatacctgg 1323901 catagccata tcccccgccg gccgttaaag ccccggcagc aagagcgccg aacattcctt 1323961 ttagaaattg tcttctggac atctttttca tttcaaacca acctttaata gagtttttct 1324021 attatatcat ctgtatctga taaaaatctc atatgagcat gtgctgacag aggcagggat 1324081 ataatgatag aatattattg aatgaataat cattcacaat tggagggata aacatggaaa 1324141 aaaaggcggt aattattacc ggcgggtcaa gcggcatggg aaaagcgatg gcaaaaaaac 1324201 aggctgaatt agggtggcac gttatggtga cagggaggaa ccatgaggca cttgaggaaa 1324261 caaaaaaaga aattcagacc tttgagggac aggtcgcttg ttttcaaatg gatgtccgtt 1324321 ccgattccgc cgcttcagac atgattaaag aagcggtaaa agcctttggc cggcttgacg 1324381 cgctgattaa caacgcggcc ggaaacttta tttgtccggc agaaaagctg acgcccaatg 1324441 gatggaaagc cgttattgag attgttttaa acggcacatt tttttgcagc caagcagcgg 1324501 caaggcattg gattgaccag aagcagcagg gtgtcatttt aaatatggca gccacgtacg 1324561 cttggggagc gggagcgggg gtcgttcatt ccgctgcagc caaagcgggg gtattgtcat 1324621 tgacaagaac gctggccgtt gaatggggga gcaaatacgg cattcgtaca aacgcgatag 1324681 cccccggacc gattgaacga acaggcggtg cggagaagct atttgaatcg gaaaaagcga 1324741 tggcccgcac gatgaacagt gtgccgctcg gccgattggg cacaccggag gaaatcgccg 1324801 ctttggcagc gtttttgctt tctgatgaag catcctatat aaacggggat tgtatcacaa 1324861 tggacggggg gcaatggctg aatccttatc cgttttaatc tgaatattta taagtgaata 1324921 tttaagttat taagaacttt tatgttcgaa tgtaatacct ccacaattaa ccttcttcct 1324981 atccaatttg ataacacata gagctttatt tgtttatgag gtgttgtgtc atacgtaagc 1325041 cacctaatat atgaaaggta tattttaaaa ggggagacga aatatgaaga acttagattt 1325101 caaataaaac attcatataa ttacttcgtt aactaaaaag agaaattata agaatgaaag 1325161 gtttcaaggt tacatcagat tgggaggaag gtaatataat ggacgagatg gtattattaa 1325221 ctcaggaatg gctcaatgaa acgtacaaag gaaaaagtgg ctacaattcc attgaggaaa 1325281 atgggaaaac tggctggaaa acaatgtatg cattaactag agcattacaa ctagaattgg 1325341 gaattacaca gacttccgac agttttggtc ctacaacttt aagaaagctt aaagaattag 1325401 gcccgatttc tacgtcaact aattcaaaaa aaaatattgt gaaaattatt caaggtgctc 1325461 tttattgtaa aggttatggt ccaggtggat taacgggtac atttggtcag ggaacgaaag 1325521 aggcgatagc agaaatgcaa ttgcatatgg ggctttctaa aacagacggt gtagtaacgc 1325581 ctaaggtgtt taaagcttta ttaaacatgg actcttatat ccttttaaat ggggcgtcag 1325641 agaaagttcg ttcaatacag caatggctaa ataataaata ttacaataga gagaatttct 1325701 actttatgcc ctgtgatggc ctgtattcaa gggatactca aaagtctctt gtttatgcaa 1325761 tacagtacga ggaagggtta agtgatagta tagctaatgg gaattttgga ccaactactc 1325821 aaagattgat tcctgtatta agaattggag aaacagatga aaaaaacagt tttattcatt 1325881 tatttcaagc tgctctaatc tttaatggct acaatgttcc ttttgatgga gtatactctg 1325941 aatctgtaag atcaaaagta aaggcttttc agtcttttgc aaaattacaa cagagtggta 1326001 ctgccgactt tcaaacatgg gcttcacttc tagtaagtac tggagacccc aatcgaaaag 1326061 gagttgcttg tgactcaatt actcaaatta catcggacag ggcggagtcc cttaagaggg 1326121 caggttataa gattgtaggg cggtatctaa caaatgcgcc ggggagtaca ctaaataaaa 1326181 aaatacaacc aggtgaatta gaaactatct taaaatcagg tttaaatgtt tttccgattt 1326241 atcaaaccta tgggggagca acaaattatt ttaataaaga acaaggaaag aaagatgcgt 1326301 ttgctgctta taaagcagca aaagaatacg ggtttaaaaa taacactgta atatactttg 1326361 cagtagatta tgatgcatat ggtaacgatt taaacaacaa tattattcca cacttcgaag 1326421 gtataaatga aataatgaac ggttttttag gttcaactta caaaattggt atttatgccc 1326481 ctaggaatgt atgtactata gtttctaaaa aaggtttagc atttgcaagt tttgtaagtg 1326541 gtatgtctac tggctttagc ggaaacttag gatatccttt gccttacaat tgggcgtttg 1326601 accaaatttc aacaattact gttggaaatg gttctggaat gattgaaatt gataatgata 1326661 tttgttcagg tttggataat ggagttaata ccataaatat agtgccttca gagaataaga 1326721 agttttttga tcaaattgat gttttatatg aaactgctga aaaatatgct caaatgcaaa 1326781 gcgacttaaa taatggggta aaaaaaacac aattagctaa tgagttggtt gcccagtatt 1326841 taagaaagga tgactacaaa gggtggaagt gggtccctac cgcaggccag attgatccta 1326901 tttatcgtga atgggcagta aagcgctagg ggaagaccta gtaaatggaa ttgttgatcc 1326961 tatatcaaaa actgtcatag gaacgcagca tcttatggca acttataatg ccattattta 1327021 tagtggtggt tactctcaaa cactacgaga ttttgctggt tggactggag atctattaac 1327081 aacaatacag gacatgaaat tacacgctca agaatttaat tcgccttatg atgcggctat 1327141 gaaaataata ggtaatatgt atcaatttag cctagatgat ttatttagtg atgtagatgc 1327201 aattaatcta gcgaataaaa catcagttgg tgctaatgca caacctctaa atatcgcaat 1327261 tagagattat tatagtaata atgactgtat gaataggttc actcaatttg taaataatag 1327321 atttgatggt tcgttagaca aaattttctc tgaagcagag tattatttaa atacaaacct 1327381 tgacccagtt gttgttccaa ttaggttagc ctttaaacgt gcttttgatg ttgaggatta 1327441 tagtgaagag attggaaaaa taacagcaca agcatttaga gatgttatcg agaaaaaaat 1327501 gatatctgaa taaactgcaa aacaagcgaa cgttaaaact ggtcgttcgc ttgttttatt 1327561 ttctatttaa atttatgata taatttttaa agattaagga gtgattcatt gaagaaattg 1327621 ttaaaaaagt tagttgtatt atttttaagc agtttagtta tcatctttaa tgtttggtac 1327681 tttattattt gtgctttttc cccagagtat tatcaaaata caaatcttac ttctaatgaa 1327741 ataataagat ttgaaaaact ataccacata gattttcctg atgaaacaaa atttattaaa 1327801 gctagagagt atttggctgg gcccggagga gatacgtcag ctgtattata tgtgtctctg 1327861 ccaaccaagc gggtagaaaa agttttatct gattacacgt atatgaaaat aaactatact 1327921 gacaatgtcg gttcaatgta tggagttgac gtttcaaaga gtgtcgccgg tttaacaact 1327981 cttacatttg gcacttacga taaaaaagga actttctata atatgaaaca tgatgatgat 1328041 tggatgtata aaggcactga ctggaatctt tacttttgga cagctgctag ttataatgct 1328101 gttatttttg tatttgtttt ggttattgtg aaacaaatga ataaaattct taattaacca 1328161 gtatgtagat tgataatctc aaaaaaattt tcctcttctt ttaacatact ccatacgacc 1328221 tacttttcca tactatgatt tttttgaaat ttgtggtgta gttataattg tgcgtataat 1328281 cagacaaaga tagagaagca ggtgataaca tgttggatcc acttgatatt ttaacgaaca 1328341 ttgatgatgt ccttccatat taccaggcga tttttagtgc cgaggagcag aaggttgtcg 1328401 gatatgaggt gcttggacga attttggcag attcagaaat ccaaagtctc gggcccttct 1328461 ttttagatgc ggggataccc gaagaatata aattagaggt tgataacaga attatccgcc 1328521 aggctcttga ccgcttttta gaggcggatt ctgatctgct gatttttatg aatcaggatg 1328581 ccaatctgct gatgctggat catggtgaaa gctttctgga gcttctgaaa gaatatgaag 1328641 cgaagggaat cgaactccac cgttttgtgc ttgaaattac agagcacaat tttgaagggg 1328701 atattgagca gctctaccat atgcttgcat actatcgtac atacggaatt aaaatcgcag 1328761 ttgacaacat cggaaaagaa agcagcaact tggacagaat cgcgctgctc tcaccagatc 1328821 tgttaaaaat cgatttgcag gcgctgaaag tgtcacagcc gtcaccgtca tatgagcatg 1328881 tgctgtacag catatcttta ttagcaagaa aaatcggtgc ggcgctgctg tatgaagaca 1328941 ttgaggcgaa cttccagctt cagtacgcct ggagaaacgg aggccgctat tttcagggct 1329001 attacttagt gtctccatct gaaacgtttc tagagagaga tgtattgaaa caaagactta 1329061 aaactgaatt tcaccaattt atcacacatg agaaaaagaa actggagacc gtctatgagc 1329121 actctgaaca gttttacaaa cgagtgcatc aggctgtgac ctctttgaga aaaaacaatc 1329181 tgtcttctga tgatgacttt attaaaaagc tggcggaaga gctgacagat tgcagcttca 1329241 ggatttacat gtgtgatgaa gaaggcgatc agctgacggg aaatgtgttt aagcaagatg 1329301 gagaatggat ttatcagccg gaatatgcgg aaaagaactg gagctggcgc ccttattttc 1329361 tggagaacat tatgagaatg agaaatctca gaaaaggttt tttcagtgat ctgtacagtg 1329421 atttggaaac aggtgaaatg atcagaacgt tttcatatcc gatggatgat cagatgtatt 1329481 tatttataga cttgccttat tcttatttat atgagcagga cggactgatt taacggctga 1329541 aaggccgttt tttttatgaa atgaaaaaaa tatcaaaaaa cgattgacat tgatactgag 1329601 aatcattatc atttaattat agagagaagc tactctctgt tccccaaccc ctctatcaga 1329661 tcaagatccg aaaaaacttg gcgctacccc cgccaagttt tttatttgtc aaagcatagg 1329721 acaatccaat gaaacaataa acctaactag tggtaaacgt ttaacacggg gagaaacatt 1329781 gagtgccgaa cacccctgac actgctgcac gggtgaggag gaaaattcgt tctgaaatga 1329841 ttatttcagt tccgttgttt acctctatcc agcatgactc ccattgatta tggccacgcg 1329901 ggacttcacc ataaaattca aaagaaggtt ttgacaaagt tgcaaaaagg cattcttaat 1329961 gctgccaaag attcgaaaaa aattataatt atgtgcatga cattcaaaaa aagcctcaaa 1330021 ctaaagaaaa atagtttttt tcactttttt tctttgctta aattcagcag tgaaaatgcc 1330081 atcctgtccg actttatggt atgatgctca atagaacttg tattataata aatacttgtt 1330141 gatttgaagt tgctttttga aaggagtctt tttttagaat gtcacaatta atgggtatca 1330201 tcacacggct gcaaagtctg caagaaacag cggaagcggc taacgagcca atgcagcgtt 1330261 atttcgaagt gaatggtgag aaaatatgca gtgttaaata tttcgaaaaa aatcaaacgt 1330321 ttgaactgac ggttttccaa aagggtgaaa aacctaacac atatccgttt gataatatcg 1330381 acatggtttc catcgaaatc tttgaacttc ttcagtaaga ttcctgaaat agggggaaca 1330441 agcttccgcc tttgcaaaag taatcgaaat aaacggtaag gaacatactt gtttcatggt 1330501 tgtaaatcct tgaaaaggag tgtcgtgatg gctgattctt ttctgtttta taatctttca 1330561 gaagcacaga tgacctttca agatgtgatg gaacggctta aagcctttgt tcaaaaggac 1330621 ccccgttctt cttatgtgtt atcgatcgga accgattcac aggtttaccg cgattacaca 1330681 aagtttatta ccgcattgca tttgcatcgt acaggcaagg gagcttgggg ctgcttgaaa 1330741 aatcatacag tcgacagacc catacatagc cttcgggaga agatttcgtt agaaacggcg 1330801 tacagccaag aaacggccgc tcatattctt gatggacact taatggatat taccgatctg 1330861 ctcctgccct ttaccggtga gggggcggat cttacctttg aagttcactt ggatattggg 1330921 aaaaaagggc ttacaaaaga tctgatccaa gaaatgactg gacgtattac ctccatgggg 1330981 attgaggcca aaataaagcc ggattcatac actgccttca gctatgcaaa tcgtttcaca 1331041 aaataatttg gctgaaaaag ccaaggtaaa tgtcgaatta tgcggttgac gtttgttatc 1331101 tgattactta ttctagcggt agagctgaaa gtaagttgtc ttgctttcag aggtattcag 1331161 tataaaacag ggggcctgat tgcgaatgag tcttatcggt gaacgattta cagaagaaga 1331221 acaaaaactt ctgctgaata tcctgatcaa ccatgagtat gccatcgagc tattaagcag 1331281 tgagatcaac gatatagaga cagggaccaa aaacgttgac ggaaccacct acaaaaaact 1331341 tgtaacgcta tacgaccgat ttcgatttga aaattaatgg gacaccctat aattgatact 1331401 ccacaaagag tatctttttt attgaaagga aacttttcga caaatactga taaagtttat 1331461 attattgcaa tatagggaat gtattgatga tgaaaatgaa aaggggtcga aaacatgata 1331521 agcttacaat cagatcaact tcttgaggca acagtcggac aatttatgat tgaggcggac 1331581 aaagtagcgc acgtgcaagt cggaaataac cttgagcatg cattattagt attgacaaaa 1331641 accggataca cagccatccc ggttctggat ccttcctacc gtttacatgg cttaatcggg 1331701 acaaatatga tcatgaacag tatttttgga cttgagcgaa ttgagtttga aaagcttgac 1331761 caaatcactg ttgaggaagt catgctgacc gacattccgc gccttcatat caatgatccg 1331821 attatgaagg gattcggcat ggtcattaat aacggatttg tctgtgttga aaatgacgag 1331881 caggtatttg aagggatttt tacgagaaga gtcgttttaa aggaattgaa taagcatata 1331941 cgctcattga ataagtaggc tgtacggtcc tatttttatt atataggcag agtgaaaaaa 1332001 gaaagcgcat acataattta aacgagaata gggcttgaat aagaaactaa gattttatta 1332061 gaatgggaga taagaaaaac ttattgataa caaaaaggag gacgacatgc agcttcaaga 1332121 gcttcatatg ctcgtagttt tagctgagga attaaatatg agaaaggcgg cagaacggct 1332181 ttttgtatct cagccggctt tatctcagcg cttacaaacc attgaaaagg cgtggggaac 1332241 aaaaatcttt ttaagatctc aaaaaggatt aacggtaacg cccgccggtg agaaaatcat 1332301 tcagtttgcg aatgatgtga cattagagca ggaaagaata agagaaaata ttgacgagct 1332361 tgaaggtgaa attcacggca cattgaagct tgccgtcgcc tccataatcg gtcagcattg 1332421 gctccctaaa gtcctgaaga cgtatgtgga aaagtatccg aatgcaaaga tctcgctcat 1332481 aaccgggtgg agcagcgaaa tgctgaaaag cttgtatgag gatcaggttc atatcggcat 1332541 tataagaggc aaccctgagt ggaaggggcg caaagattac ttaatgacag atcatctgta 1332601 tttagtggat actgaaattt cctgcatcga agatattgcc catacagaac gtccgtttat 1332661 ccagtttaaa agtgacagca cttattttca ggaaattcag cactggtggc atcaaaaatt 1332721 taaaacgtcg ccgaaacaga cgatattggt tgatcagatt gaaacgtgca aacagatggc 1332781 gctgcacgga atcggttatg ccattttgcc gtctgttacc cttcaaaatg aagataaagt 1332841 gaataaaatg cctcttttag acatgaaagg gcatccgatc ggtcgggata catggttatt 1332901 aggttatgag cctgcctttg aactgaaaca agttcaagct tttgtacaag tgataaagga 1332961 tatgctggat caggaaaatc cattttaaag acagcgaggt gctgtctttt ttttatttat 1333021 ctgttgacaa tgaaaatcat tatcatttaa agtgatacat atgatattga aaatcattat 1333081 caactaatgg ggtgataaca tggctaaagc cttgattaca tatgccagca tgtcaggaaa 1333141 tacagaagac attgccttca taataaaaga tacgcttcag gaatatgagt tggatatcga 1333201 ttgtgtcgag ataaatgata tggatgcgtc ttgtttaacc tcctatgatt atgtactgat 1333261 tggcacctat acatgggggg acggcgattt gccctacgaa gcggaggatt ttttcgaaga 1333321 ggtcaaacag attcagctta atggtttaaa aacagcctgc ttcgggtctg gcgattattc 1333381 ttatccaaag ttttgcgaag cggtgaattt gttcaatgtc atgctgcaag aggcgggagc 1333441 tgctgtttac caggaaacac taaaaattga attagcgcct gaaacagatg aagatgtgga 1333501 aagctgccga gcgtttgcga gaggttttct tgcatgggca gattatatga acaaggaaaa 1333561 aatccatgtt tcataaaggg gcaaccgctg ttacggcatc ggcgttttct ggatattttg 1333621 tggcggtaca aagagaaggc atttttcatt actctttgga gcagggctgg agaaagcttt 1333681 ttcgtttgaa aagtaagata cactgtatca gctacatagg gccttactta tttggcgttg 1333741 gtgaaaaggg aacagtcatt cgttcggctg atgaagggaa aacctggacg atgtcgagct 1333801 ttccgacaaa tgcaacagtg tgggcgatta ccggcagaaa caacgggttt gtctgcgccc 1333861 acggtaagca ttgtatttat gtatcggatg attttggtgt ctcatggcgc gtagccaaac 1333921 cttttgccga atttcataat ccccctgtta tccggtcgtt atgccttcac gggggcaatc 1333981 tctttatcgg cacgcaaata cacgaatatt ttggcggcat ttgggcttac gacattaagc 1334041 gtgacactgt ccaagttgtc aaaaaagaaa aaaaccggat gacggcatcc atgctcgtgt 1334101 tcaatgaaaa ttggctggtg gcggcgatgg gttctgtgaa aggaaagcac ggtgctgtca 1334161 ctgtaaggaa tcttttgaat ggtgaagaat tcaccataca atccagtatg atcagaaatg 1334221 aagaatcatt tcttgatctt tcagaggatg atggcattat atatgtcact acaacacaag 1334281 atgaaaatgg tttttcgaga atttaccagg ttgatctcga agcccggtcg ttaaaatggt 1334341 tcgataccat taagggacat ggatggagag tggccaatca gaaagagaat ttcttttgcg 1334401 caggcttgta tgaatgtaaa tttgtccagc cgtacgaagt ttcagcaatg attcattaga 1334461 ggaggaacaa ggaattggcg aagattttgc tcgtttatgc aacaatgtca ggcaacactg 1334521 aagctatggc agatttgatt gaaaaggggc ttcaggaggc gttagcagaa gtagaccgtt 1334581 tcgaagcaat ggatattgat gatgcccagc tgtttaccga ttatgaccat gtcataatgg 1334641 gaacctacac gtggggagac ggagatctgc ctgatgaatt tttagatctt gttgaagaca 1334701 tggaggagat tgatttttcc ggcaaaacat gcgctgtatt cggttccggt gatacagcat 1334761 atgaattttt ctgcggagcg gttgatacgc tagaggcaaa aataaaagaa cgcggtggag 1334821 acattgtgct gccttcggta aaaatcgaaa ataatccaga aggtgaagaa gaggaagaat 1334881 taataaactt cgggagacaa ttcgcaaaga aaagcgggtg cgctgtctga tcactcactg 1334941 ggaactgcta aaacggctgt tccttttttt cttgtctttg tatctttcct ttgatacagt 1335001 aatgaggtag aaaatcagga ggaggactat acatatgaaa atgatggacg caaatgaaat 1335061 tatttcattt attcaaaata gtacaaaatc tacacctgta aaggtttacg tgaaaggtga 1335121 gctggaagga atcaatttcg gtgaatctgc gaaagctttt atcaatggaa acactggtgt 1335181 cgttttcggt gaatggagcg aaatccaaac agcaatcgaa gaaaaccaaa gcaaaatcga 1335241 agactatgtg gttgaaaatg accgccgcaa ttctgcgatc ccaatgcttg atcttaaaaa 1335301 catcaaagcg cgtatcgagc cgggtgcgat catccgcgac caagttgaaa tcggtgataa 1335361 cgcagtcatc atgatgggtg cttctattaa tatcggttca gtcatcggcg aaggcacaat 1335421 gattgatatg aacgttgtgc ttggcggacg agctactgtt ggaaaaaact gccatatcgg 1335481 cgcgggttct gtacttgcgg gcgttattga gccgccatcc gctaaaccgg ttgtgattga 1335541 agacgacgtc gtaatcggcg caaatgctgt tgtgcttgaa ggtgtaacag taggtaaagg 1335601 agctgttgtt gctgcgggag cgatcgtggt aaacgacgtt gagccataca ctgtcgttgc 1335661 aggcacacca gctaaaaaaa tcaaagacat tgatgaaaaa acaaaaggca aaactgaaat 1335721 caagcaggaa ttacgccagc tgtaaggaaa agtttgataa aaaaggcgtg gataatatat 1335781 ccacgcctta ttcgtatagg caggaggaat agaaatgaag atagaggagc tcatcgcaat 1335841 tcgcagagat ctgcatcgta taccggagct tggatttcag gagttcaaaa cccagcagta 1335901 tttattaaat gtcttggaac aatatccgca agacagaatt gaaattgaga aatggcgaac 1335961 agggcttttt gtaaaagtga acgggacggc gccggaaaaa atgctggcat acagagcgga 1336021 tatcgatgcg ctttctatag aagagcaaac tggtcttcca ttcgcatcag agcatcacgg 1336081 caacatgcac gcctgcggtc acgatttgca tatgacaatt gcactcggca ttattgatca 1336141 ttttgttcac cacccagtca aacatgattt gctttttctg tttcagccgg cagaggaagg 1336201 gcctggcggt gcggaaccaa tgcttgagag cgatgtatta aaaaaatggc agcctgattt 1336261 catcactgcc cttcatattg ctccagagct tccggtaggc accattgcga caaaaagcgg 1336321 ccttctattt gcgaatacat cagagctagt catcgatctg gaaggcaaag ggggacatgc 1336381 ggcatatccg catttggctg aggatatggt tgtagcagca agtacacttg tcacccagct 1336441 gcaaacgatt atctctagaa acacagatcc gctagacagt gctgttatta cagttggtac 1336501 cattaccgga ggctcggcac aaaatatcat tgcagaaacg gcccacctgg aaggcacgat 1336561 ccgcacgctt tctgaagaat cgatgaaaca agtaaaggaa cggattgaag atgtagtgaa 1336621 aggaatcgaa atcggattcc gctgcaaagg aaaagtgaca tatccgtctg tatatcacca 1336681 agtttacaat acgagcggat taacagaaga atttatgtct tttgttgctg aacatcaact 1336741 ggcgacagta attgaagcaa aagaagcaat gactggagag gattttggct atatgctgaa 1336801 aaaatatccc ggattcatgt tctggctcgg cgctgattct gaacatgggc ttcatcatgc 1336861 taagctgaat cccgatgaaa atgcgataga aacagcggtt catgtcatga caggttattt 1336921 ttctgtttat gccaattaag tacaaatgaa agaataaaat tccataaaat gagcactcta 1336981 gtaaacggag gtgttcaaaa atggctaaaa aaattggaat tgaacaatcg ttatcagatg 1337041 tagaagctgc tttaaaagaa aaaggatatg acgttgtaat gatgaaaagc cctgctgatg 1337101 ctcaaggctg tgactgctgt gtcgtaacag gtcttgataa taatgtgcaa gggatagccg 1337161 atacggtaac acaagcacct gtcattacag cttccgggat gacggctgaa gaaatttgta 1337221 gcgaagttga gagcagaatt cagtaataaa aaaaccgaag caaaaagctt cggttctttt 1337281 atttattctg tttctttagg gaaagcgcgg tcgaacgcgt tctttatttc ttttctcaac 1337341 actcgttcga ctcgccactg ttccatattt tctgttttgg caatgaccct gattacaatt 1337401 tcagaagtcc ccagttcttg aatcccgatg acatttgggc cttcttttat ttgtggaaga 1337461 gccgctgccg tttcatcaca aacctgctgt aaaatatgaa tcatttcatc aatatttctt 1337521 tcagccggca ctttaatgtc aacaagagcc tgcatggtac cacgagaatg attgctcacg 1337581 tttgtgatgt ttctgttggg gatgtaatgc agtgttccgt caaagctgcg gatttgagtt 1337641 gtccttaagc caacctgctc gacaattccg tcaaaggtgg aaacggtaat ataatctccg 1337701 acatccaatt gtttctcaag caaaataaaa aaacctgtca cgatatcact gacaagccct 1337761 tgggcgccaa atccgacagc caggccgacg attcctgccc ccgctaaaag agcgcttgga 1337821 tcataatgaa acaaatctag aaccatgacg aaaaatatga aaatcaatgt ataagcaaat 1337881 atgttaagag tcaggcttcg gagcgtatgt gcacgtccga tagacaagct attctgctcc 1337941 tcgaattttg caaacagatg tttaatgatt ttcatgccta atgatcgaac gataaaatag 1338001 agcaatatca taatggcgag tttaatgagc agaacaccgg catttgtaat cagtcccgcc 1338061 caatcatatt gtttaataaa gtccatgttg agctcctttt ctaattgatt gctgcacatt 1338121 gagactagtt accctgtaca tgaccatgtt aaacgtttta ttcaaaaatg tcgaagccaa 1338181 agacatacat gatttgttaa aaattgactc aggaaatctg cttttatata atggcattgc 1338241 aatataacta aaaatggtta atcacccttt attttcatgc gattttgacc tttaagccaa 1338301 acaataaatt ggagggatac atatggcaga acgtatggta ggtaaacaag ctcctcgttt 1338361 tgaaatggaa gcagtccttg caagcaaaga attcggcaaa gtaagtcttg aggaaaacat 1338421 gaaaaacgac aaatggacag tgctgttctt ctatccaatg gacttcactt ttgtttgtcc 1338481 gacagaaatt acagcaatgt ctgaccgcta tgacgagttc gaagatcttg atgcagaagt 1338541 catcggggtt tcaactgata ccatccatac tcatttagct tggatcaata cagaccgcaa 1338601 agaaaacggt cttggccagc tgaaataccc gcttgctgct gatacaaacc atgaggtatc 1338661 ccgggaatat ggcgttttaa tcgaagaaga aggtgtggct ttgcgcggat tgtttattat 1338721 taatcctgaa ggggagcttc aatatcaaac tgttttccat aacaacattg ggcgtgatgt 1338781 tgatgaaacg cttcgtgttc tccaggcgct gcaaactggc ggactctgtc cggctaactg 1338841 gaaaccaggc caaaaaacac tttaattctt tccaagaacg aaaagcggtc tagcatattc 1338901 gttaggcctc tcttttaaaa taggagggaa aaagcaatga aattacgtca gcccatgccg 1338961 gaattgacgg gagaaaaagc ttggttaaat ggtgaagtga cgagagagca attgattggg 1339021 gaaaagccga cgcttattca tttctggtcc atcagctgcc acttgtgcaa agaagcgatg 1339081 ccgcaagtga atgaatttcg tgataaatat caagatcagc tgaatgttgt agctgtacac 1339141 atgccccgtt ccgaagatga tcttgaccct ggtaaaatta aagaaacagc tgctgaacac 1339201 gatatcactc agccgatttt tgttgacagt gaccatgctt taaccgatgc atttgaaaat 1339261 gaatatgtac ctgcatatta tgtgtttgat aaaacaggac agctccgtca cttccaagcc 1339321 ggcgggagcg gtatgaaaat gcttgaaaaa cgtgtgaacc gcgttctggc tgaaacggaa 1339381 taggtatctg actaaatagt atttcctaaa aacctgacct catcaggttt tttatttgtg 1339441 caaaaagcaa tggaagaaga gtaagaagct tatttttcca aatttgggta taggaattga 1339501 tgatttgttt gattgatacg ctaaaaaaca cagctaattt ttgatgtttt tcctcaattt 1339561 tagataaatc tcatatctca taactcgaaa attgtagata ttacactaaa tttctttaaa 1339621 gaagtaagta aaatatatat tttcaacatt ataccaaata aactagaaag ccccttaatc 1339681 ccttgagaat aaaggactct tttgaaaaat aaaacatttt cagaaaataa ggaatttttc 1339741 atagagtaaa tataatagta aaatgctaaa ataatagttg ataaaattac ttttgtaatc 1339801 taatatctta attaaagatg ttaattttga tagggggtac attgaggaat gtttaatgaa 1339861 agagaagctt tgcgcttgcg gttagaacaa ttaaatgaag ctgaagtgaa agtcattcgt 1339921 gaatatcaaa ttgaacgtga taaaatatac gcaaaattaa gagagctgga cagaaatgga 1339981 agcccttccg aaatcaaaaa ggatttccgt tctgaaaaaa aacctgactc tctgccggtt 1340041 ctcgctgagc ttgcggctca ggaaatcaga agctatcagc cgcaatcaca gcagcagtct 1340101 gttcagcctc agcttcaatc tatttcctct cttcctgccg gtataccaga cggaacaaca 1340161 cgaagaagaa gaggaacggc aagaccggga tcaaaagcag ctaagctgcg tgaagctgct 1340221 attaaaacat taaaacgcca caacgcggcg attaagagct cggagcttca aaaagagatt 1340281 gaaaaagaaa gcggtcttga aatccctaat atgacaacgt ttatgcaaag cttaattaaa 1340341 atgtacccgg aagtgaaaaa gccatatcgc gggcagtaca ttttagaggg tgaaatcgaa 1340401 tctgcagaat cagcaaacga ataaatataa agaaaaactg cttggcatcg ctcaagcagt 1340461 ttttttattg aggttttttc tgtgaaggtt tgttttcttt ttcaagatta agcttataca 1340521 cccacttttg ataaggcttt tcttcagcgg ctctgttttt cagctcttcg attgtatggc 1340581 tcttggcctg gtctgatgat tgggcgtggg caagctgttt ttgaagcaca tgtatctgtt 1340641 tggtgacatc ttcaaggata gtctctacat gatttggctg cgcgtaggcc gctggagctt 1340701 cttcttccgt tttttctttt tgtttcgtgc cgccatcaat atcggcaaaa tgagaagcaa 1340761 tccaggcatc gctttcatca agttgccgtt tatacgatat aatagtttcg tgaaataatt 1340821 tttctttcgt tttttctatg tctagcagtc tttctttcgt ttctatgatt cgatctttca 1340881 tatgatcaac ttctatttta atatgtttta gctgatattc tttttctacc atttgctctt 1340941 ttagacgccc gttttcggct tttatcaatt cggcttgctg ttttgcctga agcagtgcat 1341001 tttgttcctg ctcaattgag gcttgaagtt cgctgatccg tttatgaaga tttttatttt 1341061 cttcttcgat tttgactttc gcaatatgaa gtttatgttt ttcttcgatt tcggctctgc 1341121 gtttataggt ttcagcagat agaagctcct gcaaaacaac gattttatca agcagttcag 1341181 ctcttatttg gtgcagggtt tggctggtgt gggaggcatg tttttctttt gttgacatat 1341241 gtgttaattc ggcagacagc tgctggagtt tttctttcat atcggtattt tctttgagca 1341301 gtttgttatt tttctgatga aagtagcttg cttcaagttc agaaatcagc ttatggcacc 1341361 ttgaaagctc ggattttaaa taaaggttct cctgagacac gtcgtggaaa aaaggacctg 1341421 atcttttcat tcgaaccatc tccctcatga tgttaacact acaatatgca aatactgaac 1341481 agctattcct ctttaataaa cagacaagca gtagcgttga gcctttgctt ttgctatgct 1341541 tttaacgaaa ctagaggtga gatgatatga agcatgtaaa cgtactgctg gcagggggag 1341601 cctcacgtcg ctttggagaa ccgaaggcgt ttgtcaaatg gaagggcagg atgctttacg 1341661 aatgcgctaa agaggcactt ggagaacaaa cggttatcat cagccgtccc gaatttattg 1341721 atagatttca agaaaacggt gaaaatgaag tgtatcaaga tgctgagcca tttcaaggca 1341781 tggggccatt ggctggtata tataccgctt ttaaaaagac agacggtgat ctttatactg 1341841 ttctttcctg tgacacaccg ctgatacaaa gaaggacgat gctggagctc aaacgtctga 1341901 tgattgccgg tgcggacgcg gtagtcccaa tttcagacgg acaagtgcag ccattgattg 1341961 cgatttacca caaacgtatc atgccagttc tatacgatca gctttctgag aagaggttga 1342021 gaatatcaga tttattaggc agaatttcgg tttgttacgt acaggctgaa aatatcggag 1342081 caaacccggc agagtttatc aacattaata cacgtgatga ttttagctgt ttggaagaaa 1342141 aatcgaactc cctcaagcgg gactgacggg gcaataacat gataagatga cataaaagat 1342201 aaggagaaca ggtttgatgg aggaacgtta ttcacggcaa atcagattta agcaaattgg 1342261 ggaagagggc cagaaaagac tggcagacag ccatgtgctg attgtcggag cgggagcgct 1342321 cggcactgca ggagctgaag ggctttcgag agcgggagtc ggtacgatta ccattattga 1342381 ccgtgactat gtggagtgga gcaatcttca aaggcagcag ctttatacag aaagcgatgc 1342441 caaactccgc atgccgaaag ccatggctgc caaagagcat ctatcagcga ttaacagcga 1342501 gatacatatt gaggcgtatg ttaccgaagg aacagccgaa acgcttgagc cgctgattga 1342561 aaaagcagat gtcgtgatcg acgcgacaga taattttgaa acccgcatgc tgataaacga 1342621 tcttgcccag aaaacaaaga caccttgggt ctatggcgcc tgtgtaagca gccagggaat 1342681 gttcatgact gtcattcccg gagaaacccc ttgtctgtct tgtttgtttg agcaaattcc 1342741 tgtcggcggg gcgacgtgtg atactgccgg cattattccg cctgctgtgc atatcgtttc 1342801 agcatatcag caggctgagg cattaaagct gttaaccggc caaaaagaag caatacagcg 1342861 ggggtttgtg acatttgatg tctggaacaa ttcgcatatg aagattaacg ttaatcatgt 1342921 acgccgtgag gaatgcccat cttgcggagc taatgcggta tatccttatc ttcaggattg 1342981 gaacacacca aaagctgctg tactatgcgg ccgtgataca gtgcaggtaa ggtcagaatc 1343041 attaaaaaga atcccgaaac aggagctcat taagcggctg aaaacaatcg gcaaggtcga 1343101 ggctaatgcg tttttgctgc atatttttta cgaggatttc agaattgtca ttttcaatga 1343161 cggacgggca ctggtgcatg gaacaaatga tgtgaaagaa gccaactccg tgttggcaag 1343221 agtgattgga ctgtaacaac aggaggggtc agaatgctgg agaaaagaac accgataccg 1343281 gtagacgagg cagttcggcg tgtctgccat tttcaaaaac aaggtgaaac agaatgggtg 1343341 gcgcttgaag acagccttca tcggttttta gccgaagata taactgcgga tcaccacgta 1343401 cctgcgtttg accgttcgcc atacgatggt tttgctgtca gagcgtgcga tacggcagaa 1343461 gcttcacgtg aaaacccagt tcggtttgaa gttattgacc atattggagc gggagcagta 1343521 tctgaaaaag aacttggccc gtttcaggcc gtgcggatta tgactggcgc gcaaatccct 1343581 gaaggggcag atgcagtcgt catgattgaa ctgactcaag cctttgagga gaatgggaag 1343641 tcatttatgt ctttaaaacg ccgctttcag acgggggata atatttcaaa aacaggtgag 1343701 gacgctcaaa aagggagtgt tttactgaca aagggcaccc gggtgacacc aggagtgacg 1343761 gctcttttgg caacattcgg atacgcatct gtgcctgtcg tgagaaagcc tgtagtcggg 1343821 attatcgcaa ccggtaccga attgctgaat gtcagtgatc cgctggaacc gggaaaaatc 1343881 cgcaacagca atgcgagtat ggtatatgcg caagcgatag aagcaggcgc aacaccgctt 1343941 tatttaggga aaatctctga tgaactggat aaaagctttg ctgcagttaa agaagcgatg 1344001 aaaaaggtgg acttcctgat cacaactggc ggtgtgtcag tcggtgactt tgactttttg 1344061 cctgcgatct atgaaaaact cggagcggac gtgctgttta ataaagttgc catgcgcccg 1344121 ggcagcgtga caacggtggc gcatgcaaac gatatgctgc tgtttggcct ttcaggtaat 1344181 ccgtcggcat gctatgtcgg ttttgaactg tttgtcaaac cgataatcca gacatggctg 1344241 ctcaatgaaa caccgcattc aatttgtgcg gaagctgttt tgaccaagga ttttccgaag 1344301 ccgaacccat ttacccgatt tgttcgtgcg ctcgtgcacc atcaggaagg gaagctgttg 1344361 gcgacacccg ttggcttaga taagtcgagc tctgtcacat cacttgcaga tgccaatgca 1344421 tttattatcc tgccgggcgg tacgcgaggc tacgaatctg gcagaacggt tcaagtgctg 1344481 ctcatcagag aagagaatgg aagtgaatgg ccttggtccg tcctttcccg atcgtccaag 1344541 ttgtaggatt tcaaaacagc gggaaaacaa cgtttattga gcgcattctt gaaaaagcct 1344601 ctgaacaggg agtccatttg ggctgcctga agcaccatgg tcacggcggt gaaccgcaaa 1344661 cgctcacgga aggaaaagac acggaccgtt acaaggcggc aggtgctgat gtaacagcgg 1344721 tagaaggtgc tggtgtgtta cagctgactg cccgccgcaa ttgggatttg gcacggctga 1344781 ttgagttata ccaatttctc gaaacagact gtcttctgat tgaaggcttt aaaaaagccc 1344841 cttatcctaa agtggttatc ctaagtgaaa aggaagatct ggaagcgctg caagcagtaa 1344901 atataatcgc catcatctat agaaaaaaag agcatatgac agagcatcag ggattacccg 1344961 tttttcatgc ggatgatccg gttgccgtgg attttgtgct ttcacagctg aagggggaat 1345021 ctgcataatg gaacggtttg agattacgaa aacacccatt aatactgaaa acatcatcaa 1345081 aaaagtggag aaacgggaag cgggagccat tacaacattt attggtacgg ttcgggaatg 1345141 gacaaacgga aaaagaacgg ttcggcttga atatgaggca tatgaaccga tggccgtgca 1345201 aatgcttgct caaatcggcg ctgaaatcga agaaaaatgg gaaggtgcct cagctgcgat 1345261 cacgcaccgt ataggtgtgc tcgatatcgg tgaagcagcg gtagtgattg ctgtatcttc 1345321 tccccatcga aaagccgcat atgaagccaa tgagtatgcg attgaacgca ttaaacagat 1345381 tgtgccgatt tggaaaaaag aaatttggga agacggtgag caatggatcg gcgaccagct 1345441 agaaacgaca gcttatccga acggaaaacc agacctaagc gagggagagc agcatgatta 1345501 aaattctttt atttgcaggg cttgctgaac aggccggtac acaagcaata gaaatagata 1345561 tggaacaagc aaccacagat gaaataaaag cgagtctaaa agaacaatac ggtcttgaat 1345621 ctattgatac ggctatgatt gccgttaacg aaagctatgt aaaagaaaat acctctgtat 1345681 cttcgggtga cacggtagcc atcataccgc cggtcagcgg gggatgaaaa ccggacggca 1345741 tttcagccgt ccggtttttc tgtatttcat tggcatatcc ccaagtatcc tcagcataca 1345801 atgattttct gtaagcgttt attctacata tgttactccc tataaagtaa gagactcact 1345861 ccataattag actgaaattt tgaaaaataa tagaaattta tttcgggtat cgatatagtg 1345921 aagatgataa atgttggaaa ggtgctggat atggagacat ttaaaagatt aaaaatgtat 1345981 tattggccgt acagaaaagt gtttatgtgg tcgcttctag ccatgctttt gatgactgca 1346041 attactgtcg tttatccgat tatcctgcaa attacgattg atgagatcgt actgggacgg 1346101 cagtatcagc ttgcggcgtg ggtcagctta ggatttattg cggtgatggt tttgaaagga 1346161 atggctacct tttttcatca gtatttaggt gatatgttcg ggatcaaatc cgtttatcgg 1346221 ctgagaaatg gtctgtatga aaaactgcag cggctttctt tttcttacta tgataacgcg 1346281 aaaacaggag atttgatgtc caggctgact gctgatgttg aagggcttcg ttttttctta 1346341 tcatacggtc tcgctgagct cattcgcttc ggcctgctgg tagccatcag cctgtcggtt 1346401 atgttttact attctgttcc tctcacgctt gtgacaatag ctgttctgcc atttctcgcg 1346461 gttgcggtat accggtttga caaaagagtc catcccgcct tcagaggcat ccgcaaatcg 1346521 tttgcgaaac tcaatacaaa agttcaggaa aatatcagcg gcattaatac ggttaaatct 1346581 ctttccaggg aagattttca gatcagcact ttcaataaag ccaatgcaga atacagggcg 1346641 cagtatttac aaacatcatc catttggtct gcgtatttcc ctttaatgga gttcattggt 1346701 aacacttgta ttgtagctct tctctcatac ggcggttact tggttatgca aaatcagctc 1346761 aatcccggcg agcttgttgc tttcttcagc cttgtcaatt atatgatgtg gcccattatg 1346821 aacttaggtt ttgtcatcaa tatgttctct caagcaaaag cgtcagggga acgcctgctc 1346881 gacattctgg aaaaagaaga agacattaca gatcatcctc atgctttgca taaacaaaaa 1346941 ttaaccggag atgtccattt caaaaatgtt tctcttgcat acggaaaaga acaaacaaac 1347001 gcgctgtgca atgtaagctt tgaggcaaac agcgggaagg taatcggact gttgggcccg 1347061 acaggttcag gcaaaagctc agtgacacag cttctcacca gattttacag tcctgttggc 1347121 ggaatgatta ccattgatca caaacccatc acagattatt cgttaaaaac ccttcgctcc 1347181 aatatcgggg tcgtacttca agaatccttc ctgttttcat ctacgattag atcaaatatt 1347241 tcgtatgggc ggccggatgc ctcaatggaa gacgtcatcg aagcggcaaa aagggcgcag 1347301 gctcataact ttattatgga gcttcctgat gggtatgaca ccatgctggg agagagggga 1347361 atggggcttt ccggcgggca gaaacagcgt attgccattg cgagagccat ctgcttgaac 1347421 ccgagcattt taatattgga tgatgccaca agcgcagtag atatgcaaac ggagcacagc 1347481 atacagcttg ccttaaaaga agtcatgaaa aaccgcacaa cctttatcgt cgctcaccgc 1347541 atttcttcac tgaaacacgc tgatgaaatt ctcgttttta ataaaggacg cattcgtgaa 1347601 aggggaacac atcatgagct tcttgaaaaa ggcggctact ataaaaagat ttacgatttg 1347661 caataccgtg atgtcaaaat gattaatgag ccgcatgagg tcggataggg aggggccaaa 1347721 tgaaacaagc gaaaaaacag ggggttttag agcgtttcta ttactcttca gatgaaatca 1347781 ttgaaaagcc gtttaactgg gctcaaatgt ggcggctgct gagctatgtc aaaccatatc 1347841 gaaaaacaat tttgccgctt tcttttctca ctgtattgat tggcactgct gtgaagcttg 1347901 tgatccccat tttgatcggc gtttatgttc ttgatcaagc gattacaggg agaaactcgg 1347961 agctgctgat tcagctcatt tttattatta gcggtttata tgtcctcaat tacgccgcca 1348021 atgtgttaag aatcaggtgg atgaatcagc ttggccagca tgtcatttac gatttgcgac 1348081 agcatttatt tacccatgtg cagcgcttat cccatcgatt ttttgatcag cggtcggcgg 1348141 gatcgatctt agtcaggatc atgaatgata ttaactctct tcaggagctc tttacaagcg 1348201 gagtcatcaa tttgttgacc gacttgctgc ttctggccgg cgtgattatt attttgttta 1348261 cgctgagccc tgagctgact atagccatca tggtgacatt gccgattatg ttttttattt 1348321 caacaagtct cagaaaaaaa atacgccgat cctggcaaac ggtacggctg aagcaatcga 1348381 agctcaactc tcatctaaac gaaagcattc agggcatccg ggtcacgcag gcatttacgc 1348441 aggaagaaga aaacatggcg tattttgacg gtgtcaatca ggagaactac gaatcatggc 1348501 gggaagcaac tagaaaaaat gccatgttcc gtccgcttgt agaaatgacg aatgcgattg 1348561 ggacggctgt cttgatttgg tatggagcca cactcatcat gaatgaaacc attacgattg 1348621 gcgtcttcgt ttcttttgct ttctatctgg gaatgttttg ggaacctatt tcgagactgg 1348681 gtcaggtcta taatcagctg ttaatgggga tggcatcatc agaacggatt tttgagtttc 1348741 tggacgaaca gccaaatgtc aaggagaagc cgaatgccat tcataatgaa aagataaatg 1348801 gggagatcag ttttgaagag gttgaatttt cgtatgatga aaaacgaaaa gcccttcacg 1348861 ccgtttcttt ctctattcct gcgggatcga cgcttgcgct tgtcgggcat acagggagcg 1348921 ggaagacgac gattgccaat ttaatcagcc gtttttatga tgcggccgga ggcaccatta 1348981 aaatagacgg tataccgatt aaggatcttt cccttgccag tctgcgctct caaatcagca 1349041 ttgtcctgca agatacattt attttctccg ggaccatcat ggaaaatatt cgttttggaa 1349101 ggccaaatgc ttcggatgaa gaggtgatga aagcgtccca agcggtcgga gcggatgagt 1349161 ttatttccga tttagcggaa ggatacgcaa cagaggtaga ggaaaggggc agcgtactgt 1349221 ctgccggtca gcgccagctc atttcatttg caagagcatt gctcgccgat ccggctatta 1349281 tcatccttga cgaagcaacg gcaagcattg atacagagac agaagtaaaa attcagcaag 1349341 cgttaaaaac gcttctgaaa gggcgtacag cagtgatgat cgctcacaga ttgtctacga 1349401 tccgcgacgc cgaccgcatc attgttcttg atcacggcag gaaaatagaa gaagggaacc 1349461 atgatcagct gctcgctaaa ggaggcattt atgccgggct tgtgaaagcg caatacagca 1349521 cagcgataga ataatatgaa aagccttcaa tattgaaggt ttttggaaat ttattagaaa 1349581 aacatgaaac tttttgatat ccttcccgta ctatttgtta gatattctca aggaggtttt 1349641 gaaatggaaa cgaatgtaga aaaaaacagc ggaacggcga ctgaaaagcc ttcacttttc 1349701 ggagtaatca caagtccgtc cgttcaattt gaaagaataa gagaaaggcc ggctgtatgg 1349761 ggaccgcttt tgattgttgc agcaattatc atcgtcggtg ccgtgctgca atcactcggt 1349821 acggattata gtgagctttt gaaaagccag gatacgcaag ggctatctgc tgaacaaatg 1349881 gaaactgtcg caacaataac caaatttggc ggaatggcag gcgctattat cggcggtatc 1349941 gcagcattat ttattgcccc tcttatttat tggctctgtg taaaagtatc aggcggtgtt 1350001 acgacatata aaaaaatgct ttctctcagt ctgtttgtct ctttgattag cagtctcgga 1350061 ttattggtta atggaatcgt tgcttttacg actgacgtga atcctcttta cagcacgacg 1350121 tcactcgcag ggattatccc atctgacggg gctctcgcca gtgtgttaaa tacctttgaa 1350181 attttcagca tctggagctt tgtattatta gcaatcggac ttcacaaaac gggaggcatc 1350241 tcaaaaaaag ccgggtggat ttcagcaatc attctattcg gaattttagt tgtattttcg 1350301 cttttttcag gtttaatcaa ttctgtggcg ggtgcataag ctcatgaaaa aagtctggat 1350361 cggaattgga atcgcagtta tagtcgctct ttttgttgga atcaatatat accggtctgc 1350421 cgctccgaca agcggcagcg ccggcaagga ggtacagacg gggagcgttg aagaaaatga 1350481 aatctcatca acggttatgg ttcctggcac gctaaaattt tcaaatgaac agtatgtctt 1350541 ttatgaagcg gataaaggga cattagaaga cattaaagta aaggaaggcg ataaagttaa 1350601 aaagggcacg gctttagtca cctatacaaa tgagcagctg agcctggaaa aagaacagaa 1350661 ccagttaacg tctgaatcca accggcttca aattgaccaa attcaagaaa agttaaaagc 1350721 cttggacagc aaagaaagag aactggaaaa acaggtagga aagaaagaag cagaaaaaca 1350781 aatcgaatct gaacggacag agcttcaaat gcagaaaaaa acagcggaga tcgaattaaa 1350841 acaaaccgag cttcagcggc agtcacttgc caaccgggtg tcagatttag aagtgaaaag 1350901 cgaaattgaa ggcaccgtta tttctgtcaa ccaagaagcg gcatccaaaa agtcagatat 1350961 tcaagagcct gtcatacata tcggcaaccc aaaagacctt gtcgtctcag ggaaattgtc 1351021 tgaatacgat acattgaaag tcaaaaaagg ccagaaggtc acactcactt cagatgtaat 1351081 acagggtaaa acatggaaag gcacggtttc cgcagtcggg cttgttccgg atcagcagga 1351141 gagcgctgcg gcacaaggaa cagaacaggc ggtccaatac ccgcttcaag tgaaaataaa 1351201 aggaaatctt ccagaaggaa agccaggctt taaatttatc atgaatattg aaacagataa 1351261 acggaaagca aatacgcttc cttcaaaggc agtcaaaaaa gaagatgacc aatattatgt 1351321 gtatacagta aaagacggaa aagcaaagcg agttgatgtc aaaatcggcg aagtgacaga 1351381 tgacctgaca gaaattaaag aggggcttac ccaagatgat caagtcattt tgaatccatc 1351441 tgatcaggtg actgacggaa tggaagtgaa atcctaaatg attcagcttt ctaatgtgcg 1351501 aaaaagctac cagatcggaa aggaaacgtt tgatgttctc cattctattg atttggacat 1351561 tcatcaaggt gaatatgtct cgattatggg gccgtcagga tcaggaaaat cgacgatcat 1351621 gaatattatc ggctgtcttg atcggccgac ttccggtaca tatcaattgg acggcgaaga 1351681 catttcttca tataaagata aagaactggc ggcagtccgt aaccggtcca tcggttttgt 1351741 atttcagcaa tttcagcttc ttccgcggct gaacgcaaaa aaaaatgtcg agctgccgat 1351801 gatttattcc gggataggca aaaaggaacg tcaagagcgg gctgagagag cattggaaaa 1351861 ggtcgggtta gccgatcgaa tgctccacat gcccaacgag ctgtcgggcg ggcagaagca 1351921 gcgggtggcg attgcgaggg cgatcgtgaa tgagccgaaa ttgattttag ctgatgaacc 1351981 gaccggcgcg ctggatacga aaacaagcga ggcgattatg gatcagttta cagcattaaa 1352041 tgccgaggga acgacaatcg ttctggttac tcacgagcct gaagtagcag attgcacgaa 1352101 tcggatcgtc atggtgcgtg acggaaacat tgttcctgcc agctccggac aaaggagtgt 1352161 gggagaatga gcctgttgga aaacatcaga atggctctaa gctctgtcct tgcccataaa 1352221 atgcgttcga tcttaacgat gctcggcatt atcattggtg taggctctgt cattgttgtc 1352281 gttgcggtag gacagggcgg cgagcaaatg ctgaagcagt cgatcagcgg cccgggaaat 1352341 actgtggagc tgtactatat gcctagcgac gaggagcttg caagcaaccc gaatgccgca 1352401 gctgaatcta cgtttacaga aaacgatatt aaaggtttaa aaggaataga aggcattaaa 1352461 caagtcgttg cttcgacttc tgaaagtatg aaagcgcgtt atcacgaaga agaaaccgat 1352521 gctacggtta acggaataaa tgatggatac atgaatgtca attctttgaa aatcgaaagc 1352581 ggcagaacct ttaccgacaa tgactttctc gcggggaata gagtcggaat catctctcaa 1352641 aaaatggcta aagagctgtt tgataaaacc tcccctctag gtgaagttgt ctggattaac 1352701 ggacagcccg ttgaaattat cggcgtgctg aaaaaagtaa caggcttgct ttctttcgat 1352761 ttaagtgaaa tgtatgtgcc atttaatatg atgaaatcct cttttggcac aagtgatttc 1352821 agtaacgtat cattgcaggt cgaatcagca gacgacataa aatcggctgg aaaagaagcg 1352881 gcacagctgg taaatgacaa tcatggcaca gaggattcgt atcaagtgat gaacatggaa 1352941 gagattgcgg ccggaattgg caaagtaact gcaattatga cgacgattat cggctcaatt 1353001 gcaggtattt cccttttggt cggcggaatc ggtgtcatga atattatgct cgtatcagtc 1353061 acagaacgga cgcgggaaat cggaatcaga aaatcacttg gtgcgacgag gggacagatt 1353121 ctgactcagt ttttaattga atcagtcgta ttgacgctga ttggcggtct ggtcgggatt 1353181 ggtattggat acggaggggc cgcgcttgtt tcagccattg cgggctggcc gtcactcata 1353241 tcctggcagg ttgtatgcgg gggcgtgctg ttcagtatgc tcattggtgt tattttcggc 1353301 atgcttcctg caaataaagc cgcaaagctt gatcccattg aagcgctgcg ttatgagtag 1353361 cctcatgcaa catgcatgag gtttttttat gtttagtgat ttctactatg aatataaaag 1353421 acttttttca ttaaaataag aagaaaatgt cgtacaattg tccttatttt tgtcgaattt 1353481 acagtttaca aaccctatag acatacgtta atatggagaa acgtgaaaga ttttgatagt 1353541 tattgaatga atttgaatga ttttagttgc ctaaaccgaa aatagcgttt acaatgaaat 1353601 tgtattcaaa atgaatacgt tttcattagg aggtgaagca tgctaactcc tgaacggcat 1353661 caattgatta ttgatcaaat agaaaagcat gatgtggtaa agattcaaga gcttataaat 1353721 ctgactaatg cttctgaatc aacaatcaga agagatttat cgacccttga agaacgcggt 1353781 tttttaaagc gcgttcatgg tggagcggcc aagctttccg atatcagact tgaacccgat 1353841 atgcttgaaa aatcatccaa aaaccttcac gataaactga agattgctga aaaagctgct 1353901 tctcttttag aagaagggga ttgcatttac cttgatgcag gcacgacgac attgcacatg 1353961 attgatttta tggataaaac caaagatatt gtcgttgtca caaacggggt aatgcatatc 1354021 gatgcattaa taaggaaaga aatttctttt tatctgcttg gaggatacgt aaagcacaga 1354081 acgggcgcga ttattggagg cgcttcattg gttgccatgg accagtacag atttgacaag 1354141 agttttctgg ggacaaacgg tgtccataca gaggctggat ttacaacgcc ggaccctgat 1354201 gaggcccttt taaaacagaa agcgatcaaa caggcaaaac acgcttacgt cttagcagac 1354261 ccttcgaagt tcggagaaat ttcattttcg gcattcgccg gaataggcga cgcaacaatc 1354321 attacgactg acgctgaaga gcttacattc gataattacc aagaaaaaac tgtcgtaaag 1354381 gtagtgaaac catgatttac actgtaacac ttaatccatc tgtcgattat atagttcacg 1354441 ttgaagattt tactgtagga ggcctgaacc gttcttcgta tgataccaag tatccagggg 1354501 gcaaaggcat caacgtatcg agactgctga aaagacacca tgtggcgtct aaagcgctcg 1354561 gattcgtcgg cggatttacc ggagaatata tcaaaacatt tttacgggaa gaaaacctgg 1354621 aaacagcttt ttctgaagta aaaggggata cccgtatcaa tgtaaagctg aaaacgggtg 1354681 atgaaactga aattaacggg cagggaccga caatttcgga tgaagatttc aaagcctttt 1354741 tagaacagtt ccaatctttg caagagggag atatcgttgt tcttgcagga agcattccat 1354801 cttcactccc tcacgatact tatgaaaaaa tcgcagaggc ctgcaaacag cagaacgcac 1354861 gagttgttct ggatatctca ggcgaggctc ttttgaaagc aacagaaatg aaaccatttt 1354921 tgatgaagcc aaatcatcat gagcttggag aaatgttcgg cacggccatt acatctgttg 1354981 aggaagccgt tccttatggg aaaaagcttg tagaacaagg cgctgaacat gtaatcgtat 1355041 caatggccgg agacggagcg cttctgttta cgaacgaagc tgtttatttt gctaacgtgc 1355101 caaaggggaa attggtaaac tcagtcggag caggggattc cgttgttgca ggtttccttg 1355161 ccggaatttc caaacagctg ccgcttgaag aagcattccg cttaggagtt acttcaggca 1355221 gtgctaccgc gttctctgaa gaacttggaa cagaagaatt tgtccagcag cttcttcctg 1355281 aagttaaggt cacacgtcta tagaggagga aacacaagtg aaaataactg agcttttaac 1355341 gaagcatacg ataaagctta atattgagag caaagaaaaa gaaaatgtta ttgacgaaat 1355401 ggtcactgtt cttgataagg ctggaaagtt aaatgaccga caagcctata aagaagccat 1355461 tttaaatcgc gaaagccaaa gctccacggg tatcggtgaa ggaatcgcta tcccccatgc 1355521 gaaaacggca agcgttatca acccggcgat cgcgttcgga cgttcaaaag acggcgtcga 1355581 ttatgaatca ttagacggcc agccggctca cttagtgttc atgatcgcgg cgactgaagg 1355641 cgcaaacaac actcaccttg aagcattgtc aagactttca acgctgttaa tgcgtgaaga 1355701 aatccgtaag cagctccttg aagctgagtc tgaagatgcc atcatcgaca ttattaatca 1355761 gcacgataaa gatgatgacg aagaggaaga ggaagaagaa gcggcaccag cacctgccgg 1355821 aaaagggaaa attttagcgg ttactgcatg cccgacaggt attgcccata cattcatggc 1355881 tgcggatgcc cttaaagaaa aagcgaaaga gcttggtgtg gaaattaagg tcgaaacaaa 1355941 tgggtcaagc ggcattaagc acaagctcac tgcccaagaa atcgaagatg cacctgcaat 1356001 cattgtcgca gcggacaagc aggttgaaat ggaacgtttt aaaggcaagc gcgtacttca 1356061 agttcctgta acggcgggta tcagacgtcc gcaagagctt atcgaaaaag cgatgaatca 1356121 agatgcgccg atttatcaag gcagcggcgg cggttcagca gcttcaaatg atgatgaaga 1356181 agcgaaaggc aagtctggaa gcggtatcgg aaacacgttt tataagcacc tgatgagcgg 1356241 tgtcagcaac atgcttccgt tcgtagtcgg cggcggtatt ctcgttgcga tttcattctt 1356301 ctggggaatt cactctgctg atccgaatga tcctagctac aacacgtttg cagcagcatt 1356361 aaactttatc ggcggcgaca atgcattaaa actcattgtt gcagttctgg ccggtttcat 1356421 tgcgatgagt attgcagatc gtcctggttt tgcgcctggt atggtcggcg gatttatggc 1356481 aactcaagcg aatgctggat tcttaggcgg cttaattgcc ggattccttg ccggttatgt 1356541 cgtgatttta ctgaaaaaag tatttacgtt tatccctcag tcacttgatg gattaaaacc 1356601 tgttttgatt tacccgctgt tcggtatttt tatcactggc gtattaatgc aatttgtcgt 1356661 caatacacct gtagcggcat ttatgaattt cttaacaaac tggcttgaaa gccttggtac 1356721 tggaaacctt gtgttaatgg gtattatctt gggcggcatg atggcgatcg atatgggcgg 1356781 tccgcttaat aaagcagcct ttacgttcgg tatcgccatg atcgatgcag gcaactatgc 1356841 gcctcatgca gcaatcatgg ccggcggtat ggttcctccg cttggtatcg cacttgcaac 1356901 aaccattttc agaaacaaat tcactcagcg tgaccgtgaa gctggtatta catgctattt 1356961 catgggagct gctttcgtaa cagagggagc gatcccattt gctgcggctg atccgcttcg 1357021 cgtcatacca gctgctgtag tcggtgcagc tgttgccggc ggattaactg aattcttccg 1357081 agtaacgctt ccggcgcctc atggaggagt attcgtagct ttcattacaa accatccgat 1357141 gctttacctt ttaagtatcg tgatcggtgc tgtcgtgatg gcaattatcc tcggtatcgt 1357201 caaaaaacct gttacagaaa aataagaaaa aaagcgtcct tggttcgaaa ggacgctttt 1357261 tcttatccgg ccggcaggga gcgcggttaa gttatgtatt ttattctttt ttatgataaa 1357321 gtaaaagaag agaaacaact gacatagcaa ttgtctagga ggaaacactt tgaccgagga 1357381 aaaaaatacg aatactgaga aaacggcgaa gaaaaaaacc aatacgtacc tggaatgggg 1357441 taaagcgatt gtcatcgctg ttctgctggc tctcctgatc cgtcactttt tgtttgaacc 1357501 gtatttagtt gaaggttcat ctatgtatcc cacattacat gacggagaaa ggctgtttgt 1357561 gaataaaaca gtcaactata tcggcgagct gaagcgcgga gatatcgtta ttatcaacgg 1357621 tgaaacttct aaaatccatt atgtaaaaag attgatcgga aagcctggag aaaccgttca 1357681 aatgaaggat gacacgcttt atataaacgg taaaaaagta gccgagcctt acttgtctaa 1357741 aaacaagaag gaagcagaaa aacttggtgt cagtctgaca ggagactttg gaccggttaa 1357801 ggttccgaaa ggcaaatact ttgtcatggg agataaccgg ctgaattcta tggacagccg 1357861 aaacgggctg ggactgatcg cggaagatcg aattgtcggc acatcgaagt ttgtcttttt 1357921 cccgtttaac gaaatgcgtc aaacaaaata aaaacgcctt gctggcctag gacagcaggc 1357981 gtttttattt tgaaaaagaa gcgaccaatg caatgcataa aaccgtgatg aacactgaac 1358041 cgataatagc cagcacactg aagaaaaggt gaacctgttt gttctctttt ccgcgctttt 1358101 ctaatagccg tttagaaaaa atgtgcgaaa atatgtaaat aagggctatg cctatatata 1358161 agccgatatc tttggcggta aagcctgtta cggcaaggta aaagcccgta aaaaagatca 1358221 gtaagcaata ttcagtaagt gttaaaagcc tcaacgtgtt cctccatgag agtgtgtaat 1358281 tttccaggcg gatgcattct ctctctttaa ttgtaacaca gctggctggt ttgggtgtat 1358341 aagtgttttc tctctgtttt atcagggaat catttctctt gccctgcatt catggtatac 1358401 ttttattgat gatagacatg atggaggata ataaatgatt gctgtaaata atgtaagctt 1358461 gcggtttgcg gatcgcaagt tatttgaaga tgttaatatt aaatttaccc caggcaactg 1358521 ctatgggtta attggtgcaa acggtgccgg taaatcaacg tttctaaagg tgctgtcagg 1358581 cgaaatcgag cctcagacag gcgacgtgca tatgagtcct ggcgagcgtc ttgccgtctt 1358641 gaagcagaac cattttgagt acgaagagta tgaagtgctg aaagtggtca ttatgggcca 1358701 caaacgcctg tatgaagtca tgcaggagaa agacgctatt tacatgaagc ctgatttctc 1358761 agatgaggat gggattcgtg ctgctgagct agaaggtgaa ttcgcggaac tgaacggttg 1358821 ggaagcggaa agtgaagctg cgatcctgtt aaaaggcctt ggtatctcag aagatctgca 1358881 cacaaaaaag atggcagacc tcggcggttc ggagaaggta aaagttctct tggcacaggc 1358941 attattcggc aagccggatg ttctgctgct cgatgagccg acgaaccacc tggaccttca 1359001 ggcaattcag tggcttgaag agtttctgat taactttgaa aacacagtta ttgtcgtatc 1359061 ccatgaccgt cactttttaa ataaagtatg tacgcacatt gccgaccttg attttaacaa 1359121 aattcaaatc tatgtcggaa actatgattt ctggtacgag tcaagccagc tggcgttaaa 1359181 gctttctcaa gaagcgaaca agaaaaaaga agagcagatt aaacagcttc aagagtttgt 1359241 cgctagattc agcgccaatg cgtctaaatc taagcaggct acatcaagaa agaaacttct 1359301 cgaaaaaatc acgctggatg atattaaacc gtcttcccgc cgctatcctt atgttaactt 1359361 cacgccggaa cgggaaatcg gaaatgatgt tcttcgcgtg gaaggcttaa caaaaacaat 1359421 cgatggcgta aaggtgcttg acaatgtcag ctttattatg aatcgagaag ataaaattgc 1359481 tttcactggc cgaaatgaac ttgctgttac tacgctgttt aaaatcattt ccggggaaat 1359541 ggaagctgac agcggaacgt ttaaatgggg tgttaccaca tctcaagcgt attttccaaa 1359601 agacaacagc gaatatttcg aaggcagtga tctgaacctt gtagactggc ttcgccaata 1359661 ttctccgcac gaccaaagtg agagcttttt acgcggtttc ttaggacgca tgctgttctc 1359721 tggagaagaa gtccacaaaa aagcaaatgt actttccggg ggagaaaagg tccgctgtat 1359781 gctgtcgaaa gcgatgcttt ctggcgccaa tattttaatt ttggatgagc cgaccaacca 1359841 tttagaccta gagtccatta cagcgctcaa taacggctta atcagcttta aaggcgctat 1359901 gctgtttact tcccatgacc atcagtttgt gcagaccatt gccaacagaa ttatagaaat 1359961 tacacctaac ggcatcgtcg ataagcaaat gagctatgac gagttccttg aaaatgctga 1360021 tgtgcagaaa aaattgactg aactatacgc cgaataaaaa agcagagatt tctctgcttt 1360081 ttttgatacc taaatgtgaa aggagatcac aacatgaaat ttttggttgt cggagcaggt 1360141 ggagtaggcg ggtatattgg cggacggctt tcggagaaag gaaatgatgt gacatttctc 1360201 gtgcgccaaa aacgagctga gcagcttaaa aaaaccgggc ttgtcatcca tagtgaaaaa 1360261 gggaatgtat catttcagcc cgaactaatc agtgccggag aaacagggca atttgatgtc 1360321 gttatcattg cttctaaagc atactcgctt ggtcaagtga tagaggatgt caaaccattt 1360381 atccatcaag aatctgtcat tatccctttt ttaaatgggt accgccacta tgagcagcta 1360441 tttgcggcat tttcaaaaga acaggtgctg ggcggcctgt gttttataga aagtgcttta 1360501 gacaacaaag gagaaattca tcatacgagc gcatcgcatc gttttgtatt tggagaatgg 1360561 aacggcgagc gtacggagcg gataagagcg cttgaagagg cattttcagg tgtgaaggct 1360621 gaagtcatca ttagcgggca tatcgagaag gacatttgga aaaagtatct ctttattgca 1360681 gcgcaagcgg ggatcacaac gttatttcaa cgaccgcttg gcccaatcct cgccacagaa 1360741 gccggacgtc acacggccca aactcttatt ggggaaattt gcactgtttt acgaaaagaa 1360801 ggtgttccgg ctgatccggc tcttgaggaa gagagctttc gtacgatgac cagcatgtct 1360861 taccatatga agtcctccat gcttcgggat atggaaaacg gccaaacgac agaaggcgac 1360921 cacctgcatg gatttttgat tgaaaaagca aaacgtttat ctctcgctgc accagtatta 1360981 gaaaccgttt atgcgaatct gcaaatgtat gaagcagaaa aataaaaaaa ggaggcggaa 1361041 aagcctcctt ttatttactt aaaaagccca atttccgttt ctgaagatag gctctctttt 1361101 cccgtctgcc gtaattccgt caatattcat atccttagaa ccgatcataa agtccacgtg 1361161 tgtaatgctt tcatttaggc cttctttgac aagctcttca cgagacatct gctttccgcc 1361221 ttcaatatta aaggcatagg cgcttccgat cgccaaatga tttgacgcgt tttcatcaaa 1361281 cagcgtgtta tagaaaagaa tgtttgattg tgatataggc gaatcgtaag gaacaagtgc 1361341 cacttcacct aaatagtgag aaccttcatc tgtttccacc agttctttta aaatatcctc 1361401 acctttttca gctttaatgt cgactatacg gccattttca aacgtcaggg tgaaattttc 1361461 aataatattt ccgccgtagc ttaatggttt tgtgcttgat accactccgt caaccccgtc 1361521 tttttgcggc agcgtgaaca cttcttctgt cggcatattg gccataaact catggccact 1361581 ttcattcacg cttcccgcac ctgcccaaac atgcttccta ggcagcttaa ttgttagatc 1361641 agttccttct gcttgataat gtaaggcagc gtaatgtctc tcgttcaaat ggtcaacttt 1361701 ttcatgaaga ttttggtcat gattgatcca cgcctgaacc gggttgtctt catttacgcg 1361761 cgtcgcttta aaaatttctt cccacagaag gtggatcgct tcctcctctg atttgccagg 1361821 aaacaccttg tgagcccagc ctgctgatgc cgcacctacg acagtccagc tgactttgtc 1361881 tgattgaata tattgtctgt atgtatgtaa tgctttgcct gctgcttttt ggaatgccgc 1361941 aatccgtttg gaatctatac cttttagcaa gtctgggttc gacgacacaa cagaaatgaa 1362001 agcagctcca tttttggcaa gctcttctct gccttttgct tcccattcag gatattcttc 1362061 aaatgcttca aacggcgcaa gttcgtattt taatttggcg acttcgtcat cctgccaatt 1362121 cacggtgacg ttttttgcgc ccttttcata tgcgtgtttt acaattaaac ggacaaaatc 1362181 ccgaacgtct gttgaagcat ttacgactac atactggcct ttttggacat taacgccgac 1362241 ttctaccgcc agctgtgcat atgtatttaa tttctgtgaa aatgaatcca tgaatcattc 1362301 ctccaagctt ttttctcatc atatcaaata tgatcctata aaggaaagaa ggagcccaaa 1362361 gtgaaaaacc caaaacgaca cgtcttgggt tttttcaata ttatggatga ttcagtttta 1362421 cagtgccgcc tgcaggcgaa tggggcatat ttgccaaaga aatgctcatg cctccaagaa 1362481 taattccgct taaaatggct gcgatcgcta ctcttcttcc taaatctctt agcatctgtt 1362541 tcctccttaa cgtttctcca tttcccacaa tatgaaggaa gtgaggaaaa aagaagcaag 1362601 aaatttgccg cgtgtgagaa ttttgcgggt aaagactatt taattgcctt ttgcagctta 1362661 tcaatcactt ctaaagaacg gcctgtgccg attgctacag attcaagcgg gttttgcgcc 1362721 acgtgtacag gcacgacaat ctcttctgtg agccattctt taattccatt aaggagcgcg 1362781 ccgccgcctg ttaaaataac gccgcgatca acaatatctc cgctcaattc aggcggacag 1362841 tcctcaagtg tcgctctgat ggcttcaaga atatgcagga gggattcacg cattgcatct 1362901 tgaatttcgt tggattgaag cataatggtt tttggaagac ctgtcacgag gtcacgtccc 1362961 cgaatttcca ttgcctctgg tatatgttca atcagagcat ggccaatttc catttttacc 1363021 tgctcagctg tgcgttcgcc gatcagcaaa ttgtattttt tacggacgaa agaaacgata 1363081 tcctcatcaa gctggtctcc gccgatcctg atagaatggc aggaaacaac gccaccgaag 1363141 gaaataatag cgacctctgt cgtccctccg ccgatatcta ctaccacatt ggcaaccggc 1363201 tcatcaaccg gtaaatccgc tccgatggcg gctgcaactg gctcttcgat taaatgaacg 1363261 tttttcgcgc cgcaattttt caccgcatca ctgatggcgc ggcgttctac tgctgttgag 1363321 cctgatggtg tgcaaacgac tacgttcggt tttctgaacg acatgccgat gctttttgcg 1363381 gcttttttca taatgtgctt tagcaggtca gttgtcatat catagtctgc gatcacgcca 1363441 tctttcatcg gtctgacagc gacaattttt cccggtgttt taccgatcat gtttttcgcg 1363501 tcagctccga ttgcaagcac tgcttttgtc gtcgtatcca ctgcgacaac agatggttca 1363561 tttaggataa tccctttatt tttgctgtaa acaagtatat tagctgttcc taagtcaatc 1363621 ccgatttcag ttgattgaaa catgttttca cccaatctct atcctaattt aatatgattc 1363681 tacatttaaa gtttctcaga aatactgcga tttttggggg tgtgcgtcgg taaagaaatg 1363741 tttttgtaaa aaatcaagga actgtgtaac agaagtaata catttttcgg ttttatggaa 1363801 aaaatatctt gtaattctta tagaaagcgg gaaacttttt caaagtttca ttcgtctacg 1363861 atatattgag gtacatcctt aaaacattac atgagaaaag aaacatttaa aggaagaagg 1363921 gtttttatga aatcaatagg tgttgtgaga aaagtagatg aattaggccg cattgtcatg 1363981 ccgattgagt tgagacgggc attggatatt gccataaaag acagcattga gttttttgtt 1364041 gacggagata aaattatctt gaaaaagtac aaacctcatg gcgtttgttt aatgactgga 1364101 gaaatcactt cagaaaataa agaatacggc aacggtaaaa ttacgctaag ccctgagggt 1364161 gcacagctgc ttctcgaaga aattcaagcc gctttaaaag aataaaatta tgctaaaaaa 1364221 ggcggagtga tatcatctcc gccttttttg cgtgccaatt tttgattacc gccgcctaag 1364281 ataagacatc aagatatttg gtaatgaatg atttgggata ctttacatat tttactcaat 1364341 tatttgtcga agaatggtac aataagtaga gaaacacaag cggcaggtgg tcatatgaga 1364401 aaatatcaag ctcgtatcat ttccatcatt ttggcaatga tttttataat gttttgggat 1364461 tatttatttt attttatagg caaaaacccg attaattggc ctgttgatat tgtgtatact 1364521 gcagtcacgc tggtaagtgt ctggatgttg gcttattata ttgatgagaa acagcagctg 1364581 gttaagaaaa tgaaggataa cgaatggaag tataaacagc tttctgaaga aaaaaaccgc 1364641 atcatggata atttgcagga aatcgtattt caaacgaatg caaaaggtga aattacatat 1364701 ttaaaccaag cgtgggcatc tataaccggg ttttcaatca gtgaatgtat gggaacaatg 1364761 tataacgatt acttcataaa agaaaagcac gtagccgacc acattaacac ccaaatccaa 1364821 aacaaagcgt cttctggcat gtttacggca aaatacgtga caaaaaacgg cacgattttt 1364881 tggggagaag ttcattataa actttactat gaccgggatg accaatttac aggcagcctg 1364941 ggtacaatgt cagatatcac tgagcggaaa gaggctgaag atgagctcat tgagattaat 1365001 gaacggctgg cgagggaatc ccagaaacta tcaatcacaa gtgaacttgc cgcaggtatt 1365061 gctcatgagg tcagaaaccc tttaacatct gtcagcggtt tcctccagat tatgaaaaca 1365121 caatatccgg acagaaaaga ctattttgac atcatctttt cagagattaa aagaatcgat 1365181 ttagtgctca gcgagctgct gctgcttgca aaaccgcagg caatcacatt taaaacacac 1365241 cagcttaatg agatcttgaa acaagtcacg acattgcttg ataccaatgc aattctgtcc 1365301 aatatcgtca tagagaaaaa tttcaaagag acagatggct gtatgattaa tggagacgaa 1365361 aatcagctga agcaggtctt tatcaacatc attaaaaacg gaattgaggc aatgccaaag 1365421 ggcggtgtcg taaccatttc aactgctaaa accgcctctc atgcagtgat aagcgtaaag 1365481 gatgaaggaa acggcatgcc gcaggaaaag ctgaagcaga ttggcaaacc tttttattca 1365541 acaaaagaaa agggcactgg actgggactt cccatttgtt tgagaatcct gaaggaacat 1365601 gacggggaat tgaaaatcga aagtgaagct ggaaaaggca gcgtctttca agtggttttg 1365661 cctttaaaat cagacagctg agaggagaaa aataaagtga actcgcttct gtttgtatac 1365721 gggacattaa gaaagcatga aaaaaaccat catttgctgg cacaatcggc atgtatcaat 1365781 gagcaggcga gaacaaaggg aagtttgttt gctgcaaaag aggggcccac agttgttttc 1365841 aatgatgaag atgaaggcta tatatatggc gaagtatatg aagcagatga attgtgtata 1365901 cataagctcg atcaattttt tcaaggatat cataaacaaa cggtgtttgt agaaacggat 1365961 gtcgggatta aaattgcgct tatttatttt atgaacaaag acgggtgtgc cggttttacg 1366021 aaaataagca gcggcgactg gaaagaacat cagatgatca gcaaatcgaa aaatcccatt 1366081 tattattttg cctatggatc atgcatggat aatgcccgct ttcaaaaagc gggagtcgat 1366141 cactattttc aagatccagt aggaagagct gttttaaaag gatacacaac ccgcttcacg 1366201 ctaaaaaggg aagacggttc aagagcggac atgttggaag acggaggaac aacagaaggc 1366261 gttttatacc gtatccctta ttctgctctc tcctatctat ataaaaggga gggcgtcgaa 1366321 tctcttacgt atcggccggc atttgtagac gttgaagctg gcggaaggca ctacaaagac 1366381 tgtttaacct ttctcgtcct ccaaaaagaa gcggaaattg ccccgcctca gcactatcag 1366441 attgaaatcg aacgcggagc ggagctgtat ttgtcgcctg agtttactga aaagctcaag 1366501 cggcatatga attcgctgcc aaaaggataa cactgtaaca aaagaatatg ataaaatttg 1366561 atcaatatca tgtcatataa aggagcacca cgatgaaaaa agaatttgcg gtaattgggc 1366621 tgggccgttt tggtggcagt atttgcaaag cattaagcga agaaggcgtc gaggttatgg 1366681 caatggatat cgatgaagat aaagtcaacg agtatgccaa gattgcatct cacgcagtta 1366741 tcggtgattc gacagacgaa tctgtcctga aaaatttagg cctgcgaaat tttgaccacg 1366801 ttattgtagc aatcggggaa aatattcaag cgagtatttt aacgacactc attctgaaag 1366861 aacttggcgt ccatacgatt acagttaaag cgcagaacga ttatcacgaa aaagtgctgt 1366921 ctaaaattgg tgcggatcac atcgtccacc cggaacgcga tatggcaaaa cgaattgcgc 1366981 ataatatcgt gtccaacaat gtacttgact atttggagct gtctgaagag catagtcttg 1367041 ttgaaatcgt agctaacagc cgcctggctg gaaatacgct tctcgattta gatattcgcg 1367101 caaaatacgg tattaacatc gtagccataa aaaggggcaa ggaagtcatc gtatcaccgc 1367161 ttgcaaccga agtcatccac caagaagata tactcattgt tattggatca gttacagaca 1367221 tctcccgttt cgaaaaaaga gttcttcata caaaatagca gccaaataag ccgtcctcaa 1367281 agggcggttt ttcatattat cagaatataa caactttaat gaactgagcg tcaatttctt 1367341 aaaatttcat tgactaagca caggcgttcc gatagcatat tgtaccatat aataaaaaaa 1367401 ggaggggcct atttgaataa agaagcgcta gtcaataggc tgaatgcttc agccaaaaga 1367461 caaaaagctg atatcgtcat taaaaacgga aaaatcatgg acgtatataa tcaagaatgg 1367521 atatatgaag atattgcgat tacagatgga gttattgtag gcctcggtga gtatgaaggc 1367581 gaaaatatca ttgatgcaga gggacaaatg attgttccgg gttttattga tggacatgta 1367641 catattgagt cgtcaatggt tacaccgatt gagttcgcta aagcagtgtt gcctcatggc 1367701 gtgacgacgg ttgttacaga tccgcatgag atcgcgaatg tgtctggtga aaaagggatt 1367761 gagtttatgc ttgaacaagc tcggcataca ccgctgaata tccattttat gcttccttcc 1367821 agtgtgcctg ccgcaagttt tgagcgatca ggcgcaattc tcaaagctgc cgatctcaag 1367881 cctttttatg aagaagaaga agtattaggg ctggctgaag ttatggatta tgtgtcggtt 1367941 cagcaggctg aaaaagacat ggttcagaaa ctgcttgatg cccgtgtggc aggaaaaagg 1368001 atagacggtc atttagctgg tttatcaaca gacctcatta acatttacag aaccgcattt 1368061 gtcttaaacg accatgaagt aacatcgaag gaagaagccc ttgatcgtat cagaaggggc 1368121 atgtatgtca tgatgcgtga aggatcagtc gccaaaaaca cgctcaatgt gctgccggcg 1368181 gtgaatgaaa agaacgcacg ccggttcttt ttctgtacgg atgataagca tgtggatgat 1368241 ttattgtcag agggaagtgt aaaccatcag gtgaaaatgg cgattcaagc cggacttaat 1368301 ccgtttttag cctatcagct aggaagcctc aatgcagccg aatgctacgg attagataca 1368361 aagggagcga ttgccccggg ttttgacgct gatttgcttt ttgtatctga tctggaaaat 1368421 gtcactgtca caatgacgat ggtaaaaggg cagactgttg ctgaagacag caaagcggtc 1368481 tatcaggatc atgcttcaac tgcagcacca gatcaggcac tgcttgattc tgttaagctt 1368541 gctgctcctc ttaacaaaca ggattttcat atgccaatcg attcagagca gcagatcaat 1368601 gtcattcaaa tcataccaaa tcagcttgaa acacgattag tacaagttcc ggctcctgtt 1368661 gcccgcgaat ttgagcctga cactgagctt gatttgttaa agattgcagt tgtcgagcgg 1368721 cataaaggat taaaagaaac cggacttggt gttgtgaaag gttttggatt caagagcgga 1368781 gcgattgcca caaccatttc acacgactcc cataatatta ttgccgtcgg aacgaatgat 1368841 gaggatatcg cggcggcagt taataagctg caggaaattg gcggaggatt aacaattata 1368901 aaaaatgggg aagagctcca ttcagtaccg ctgccgattg cagggttatt atccgaccaa 1368961 tctgcagagc aagtgaatca aagcttgctg acgcttcatg ataaattgtc gttaatcggt 1369021 ttcacaggcg gatttaatcc atttttgaca ttgtcgtttt tagcgttgcc tgtcattcct 1369081 gatattaaaa tgacgactac gggattattc gatgtaaaat catttcaaca catatcactg 1369141 caataaaaag aggcactccc ttagggagtg cctctttttt taaacctcca taatgatcgg 1369201 caggatcatt ggacggcgct ttgttttttc gtacaagaaa ggtgcaagcg tgtctgtaat 1369261 ttcgtttttg atttcagacc attgagtcgt ttttcgttcc attacttttt gtaagtgatt 1369321 tgaaatgagc tcttgagcgt cgttgatcaa gtcaccagat tctctcatgt acacaaatcc 1369381 tctggaaatc aaatcaggac ccgctgaaat cttgaagtcg tccatgtcaa tgctgacaac 1369441 aacgatgaca agtccttctt cagagagaat tctgcgatca cgaagtacga tattgccaat 1369501 atcaccgata ccgcttccgt caatgtacac tgaaccggac gggatttttc ctgcaactga 1369561 agcctcatcg cctttaagtg ctaatacttc accattatcc atgataaagc agttttcctc 1369621 tgggatgcca caatctgttg caagtttgac atgcatcttt tgcattctgt actcaccgtg 1369681 aatcggcatg aagaatttag gcttgattaa acgaagcatc agcttctgtt cttcctgtcc 1369741 gccgtgaccg gatgtatgga tatcgttaag agggccgtga ataacctcag cacccgcacg 1369801 atacagctgg ttgattgttc gactcacgct gattgtgttg cctgggatag gggatgaaga 1369861 aaatacgact gtatccccag gattgattga aatttggcgg tgtgtgccgt ttgcaattct 1369921 tgataacgcc gccattggtt ccccttggct tcctgtacat aaaattgtta ctttattagc 1369981 aggcatacga ttgatttcgt tatgctcaat aaacgtattt ttaggacagt taatataacc 1370041 gagtgtctgt ccaatttcga tagccgattc catactgcgt ccaaatacgg caacttttct 1370101 tccattttgt acagcagctt caattacctg ctgcaagcgg tgaatattcg acgcaaatgt 1370161 ggcgaagata attcggccgt ccaccttgcg gaaaatgtca tgaatgcttt ctcctacacg 1370221 gcgctcagac atggtaaact ccggattttc actgtttgtg ctgtctgaaa gaaggcacaa 1370281 aacgccttct ttaccgattt cggccatttt cgttaagttt gccggctcgc cgactggagt 1370341 aaagtcgaat ttgaaatccc cagtatgtac gatgtttccg ggcggcgttt ttacaacaat 1370401 gccgtaggaa tccggaatac tgtgtgttgt tctgaagaat gacacagccg ttttgcggaa 1370461 ctttacaata tcatcctcgc cgataatgtt cagtttcgtc tgtctcaata atccatgctc 1370521 ttcaagttta ttccgaagta agccgatcgc gagttttccg ccgtatacag gaatattcac 1370581 ttgtctgagc aggtatggaa taccgccgat gtggtcttcg tgcccgtggg tgataaaaag 1370641 ccctttaatt ttatcttcgt ttttgactaa atacgtataa tcagggatga cgtagtcaat 1370701 tccgagcagt tcgtcctcgg gaaacttgat ccccgcatca atcagtacaa tttcatcctg 1370761 gaattgcacc gcgtacgtat ttttaccgat ttcgcccaaa cctccgaggg cgaaaacagc 1370821 agtctgatca ttttttacaa atttcatacc gctcataact ccaatacttt aaaattttcg 1370881 ctctgttgtt catattctaa gaatgcacca tcaacaggtg taataaactc aatattaaat 1370941 ttcttttctt tcagctttgt tctgacgtca cgctcagata cgccttcaat ataaagtgaa 1371001 tctgtctttt cccgaacagg tacttcgtca gccttctctt gataaaatac cttataaatc 1371061 attccaaatc tctccttaaa tgccgtatgt tagactcgct cattctatta tattcgaaaa 1371121 cggaatataa ggaaagcctt gagcaaaata aggatctctc aaaaagtgaa agatcccttg 1371181 tcaggcaatt gctttcttac ggagcattcc gttccattgt cttctgagtt tctttcttaa 1371241 tttacgcagc attagccagt ccctccttta atgaaaaatt tgtcccagag ttcttttata 1371301 caaatagtat acggagattg aggaagactt ttcgtggtta ttaatggaat ttaatatgat 1371361 ttttgaacga aattgtttgc tgaatgacaa tctttttgta tgatgagggt gggaattgca 1371421 gaccaagacg ataaagggga agttgcgatg gattctaaat taatcttttt tgatattgac 1371481 ggcacaatat atgatcatga taagaatata ccggaaagta cgagaaaaac cgtggcggag 1371541 cttcagcgcc aagggcatca tgtgtttatt gccagcggcc ggtctccatt tttggttaag 1371601 ccgattttgg aggagctggg catccactca tttatttcct acaatggaca gtttgttgtc 1371661 tttgaaaatc aagtgattta taaaaatccg ctgcctgaaa atgcaatcag gcgattatta 1371721 aagcaggcgg atgaaggcaa gcatcctgtt gtgtttatgg ctgaggacac gatgaaagcg 1371781 actgttgcgg atcaccccca tgttctcgag ggaatcggca gccttaaaac agattatcca 1371841 gagaccgatg acctttttta tgaaggaaaa gaaatttttc agcttctttt attttgtcag 1371901 gatgaagaag aaaaagctta tgccgctttt cctgagtttg atctagttcg ctggcatgag 1371961 ctatcgactg atgttctgcc gcacggaggt tcgaaggcag aaggaatcaa aaaagtgatt 1372021 gagcgtcttc cgtttgatat cggcgataca tatgctttcg gcgacggatt aaatgatttg 1372081 caaatgattg aatacgttgg gacaggcgtt gctatgggaa atgctgttcc cgaactgaaa 1372141 gaaatcgcgg actttgtaac aaaaccggtg gacgaggatg gaattgcata cgctgtcaaa 1372201 gaattgggcc ttttaaaata aagaaacggc tggcattgtg ccagccgttt tctcttttag 1372261 cgctcaattg cgattgcatt ttcaggttct ttgaaaggat tttccttatc aatatgatca 1372321 tagaacataa cgccgttcaa atgatcgatc tcatgctgaa acacaatagc cggaaatcct 1372381 tttaaacgaa tatcaatatt ttcgccttct agtgttgttc cttttactct gatgcgagca 1372441 tagcggggaa cataaccggg aatcgcttca tccacagaga ggcagccctc gccgcttgtt 1372501 aagtagcttt tttcaactga atggctgacg atcttaggat taaacagagc atagctgtat 1372561 aatttaccgg aagcatcttc cgcatgaacg gcgatcattc gttttttgat attaatttga 1372621 ggagctgcga gtcctacgcc agggcgcagc ttgtattttt cggctaattc tggattttgg 1372681 ctgtttttaa caaattcgat catgtcggcc agctgctgtt tttctgcatc agttggaggc 1372741 agctcaacag gttcggcagt ctctctgagg gctggatggc cgtcacgtac gatgttttcc 1372801 atagtaatca agaaacttca ctcctaaagc ttaatatgta aattatatcg gatttcttca 1372861 caaaggtgca acgaaacgaa tgaccagccg tatatggctg gtcaatttca tgctgtgtgg 1372921 ttagcaacag cctccaccta aataagcagc tccgacaatg attaacagaa tgaataaaac 1372981 aacgattagc gcaaaggtgc ggccgtagcc atatccgcag ccaccatatc cgtaaccacc 1373041 ataactgcag cagcctccgc cgtaaccata tccatacata ttacataacc tcctctttta 1373101 attacgccag agcctttata agtaggcata gcgtctaata taacctatgt aaaaacaaaa 1373161 aagttgtatg gtcatctgtc ctgatttttc acttttttga tttaatttca gtattgcatt 1373221 tatacagcac ggctattgcc aaatgtcccc atggattcta tagtagaaat tgtcaagatt 1373281 gggggattta acgtgaaaga cgctataaaa cggcggcctg gaatcaagat cggagctttt 1373341 tgtgccatgg cactgatatt aacaggatgc atgggacagg acccggttga ttcacttcat 1373401 cattcattag aaaaagccgc ggaatcggaa aagccgtttc aagaagaaca aaacacactc 1373461 aaagaattag aggccaaaga aaatcagctt tacgatagtg ttatgaagct caatatggat 1373521 gattataaaa aaattgttgc tttatctaat aaggcgcttg aaaatgtcag caagcgcgaa 1373581 gaacacctaa agcttgaaaa tgacagcatg aaaaaatcgg aaacagaatt tgaggaagca 1373641 aaaacgtcag cggaacatat taaggaaaaa gacataaaag aaaaggccga tgccgcagca 1373701 aaccatatgg agaaaagata tacatcatat ggcactatgt ataaagagta taaaaaagcg 1373761 cttgagctta ataaaaaact gtatatgcag ctgaaagaca aagatttgac aagagatgat 1373821 ctggatcagc agatcgataa agtcaatgct tcttatgaaa agatccttaa atatagcgga 1373881 gaatttaatg aacaaaccga aaaatataat aaagcccggg aagatttata tgatgctgca 1373941 ggctatcgtg tgaaaaagag ctgactcgat cagctctttt tttgaatgaa atgcgattcg 1374001 gatttcgttc aaaattttca tttctattgt agtacagcat agtaaggtat actagtacag 1374061 ttttgggtgc ggttggcatc tgtttttttg atgaaaatgt aaagcgaata catttattga 1374121 aaatcagcga tgaaaacgat tgacggttct tctttatttg gtgtaaacta atccatgtta 1374181 agcggtgttg tattagtttt ttacaacttc gaaataatac agttcaaagc agagtgtaac 1374241 tatcctacat aaaaggtttt ggcaaactgg ggatcggcta aaatataata cgacttactg 1374301 ctgatacttt agggtaccct aagtttgtat gtataaaagg aatgcacgtc taatgactgt 1374361 ttaaaagaaa ggaagaggtg acttagtatg gctgcaaaaa cgaaaaaagc tatcgttgac 1374421 agtaagaagc aatttgatgc cattaaaaag cagttcgaaa cgttccaaat tttaaatgaa 1374481 aagggagaag tcgtgaatga agcggcgatg cctgatttaa ctgatgatca attaaaagag 1374541 ctaatgcgcc gcatggtatt tacgcgtgtg cttgaccaac gctctatctc attaaaccgt 1374601 caaggacgtc tcggatttta cgctcctact gcgggtcaag aagcttctca gattgcaacg 1374661 catttcgcgc ttgaaaaaga agactttgtt cttcctggat accgtgatgt gcctcagtta 1374721 atttggcacg gccttccatt atatcaagcg tttcttttct ctcgcggaca tttcagagga 1374781 aaccaaatgc ctgatgatgt gaatgccctt tctccacaaa tcattatcgg tgctcaatac 1374841 attcaaactg ccggtgttgc gctaggtctt aaaaaacgcg gtaagaaagc tgtcgcaatc 1374901 acttacactg gtgacggcgg agcttctcaa ggggacttct acgaaggaat taactttgcc 1374961 ggagcttata aagcacctgc aatcttcgtg gtgcaaaaca accgttacgc gatttcaact 1375021 cctgttgaaa aacaatctgc agctgaaaca attgcacaaa aagctgtagc tgccggtatt 1375081 gtcggcgtac aagtagacgg aatggatccg cttgctgtat acgcagcaac tgctgaagca 1375141 cgcgagcgcg caatcaacgg cgaaggtcca acactaattg aaacacttac attccgttat 1375201 ggcccgcaca caatggctgg tgacgatcct actaaatatc gtacaaaaga aatcgaaaat 1375261 gagtgggaac aaaaagatcc gcttgtacgt ttccgtgcgt tccttgaaaa caaaggctta 1375321 tggtctgaag aagaagaagc aaaagtgatt gaggatgcga aagaagaaat taagcaagcg 1375381 atcaaaaaag ctgatgctga accgaagcaa aaagtaactg atttaatgaa aatcatgtac 1375441 gaaaaaatgc ctcacaacct tgaggagcaa tttgaaattt atacacagaa ggagtcgaag 1375501 taagccatgg cgcaaatgac aatgattcaa gcaatcacgg atgcgttacg cacagaactg 1375561 aaaaatgacg aaaatgtctt agttttcgga gaagacgttg gtgtaaacgg cggcgtattc 1375621 cgtgcgacag aaggattgca aaaagaattc ggtgaagacc gtgtgtttga cacgccactt 1375681 gctgaatctg gtatcggcgg tcttgccctt ggtttaggct taaacggctt ccgtccggta 1375741 atggaaatcc aattcttcgg atttgtttat gaagtaatgg attcagtttc tggccaaatg 1375801 gctcgtatgc gctaccgttc tggcggacgc tggacttcac ctgtaacaat tcgttctcca 1375861 ttcggcggcg gtgttcatac tcctgaactt cacgctgaca gcttggaagg tcttgttgca 1375921 caacagcctg gtatcaaagt tgttattcca tcaactcctt acgatgccaa aggactttta 1375981 atttctgcga tcagagacaa tgatcctgtt gtcttcttag agcatatgaa gctttaccgt 1376041 tctttccgtc aggaagttcc tgaagaagaa tacacaattg agcttggaaa agctgacgtg 1376101 aaacgtgaag gtactgatct ttcaatcatc acttacggcg caatggttca tgaatcatta 1376161 aaagctgctg atgagcttga aaaagacggc atttctgctg aagttgtcga ccttcgtaca 1376221 gtaagcccac ttgatatcga tacaattatc gcctctgtag aaaaaacagg acgcgcgatt 1376281 gtcgttcaag aggcacaaaa acaagccggt attgctgcaa acgtagtagc agaaattaat 1376341 gaccgtgcga tcctgagctt ggaagcacct gtacttcgcg ttgcagcgcc agatacagta 1376401 tttcctttct ctcaagcgga gagcgtatgg cttccaaacc ataaagacgt tcttgaaaca 1376461 gcaagaaaag tgcttgaatt ttaatcaaac tgcataatcg agagggaaga tgaacgtttt 1376521 ccctctatta tatatctgtt ttcaatgctt acgatgtaaa ctttaaaatt gcttaatcaa 1376581 actaggaggt cgagaactgt ggcatttgaa tttaaacttc cagatatcgg ggaaggtatc 1376641 cacgaaggcg aaatcgtaaa atggtttgtc aagcctaacg acgaggtaga cgaagatgat 1376701 gtactggctg aagtccaaaa tgataaagca gtagtagaaa ttccttcacc tgttaaagga 1376761 aaagtattag aattaaaagt tgaagaggga acggttgcaa ctgttggaca aacgattatt 1376821 acgtttgatg cacctggtta cgaagatctt caatttaaag gcagcgacga gtctgacgat 1376881 gcgaaaactg aagcacaagt tcagtcaact gcagaagctg gacaagacgt tgcgaaagaa 1376941 gagcaagctc aagagcctgc aaaagctact ggcgcaggac agcaggatca agctgaagtt 1377001 gacccgaaca aacgcgtgat cgctatgcct tccgtacgta aatatgcacg tgaaaaaggt 1377061 gtagacatcc gtaaggttac tggttcaggc aacaacggac gtgttgtaaa agaagatatc 1377121 gacagctttg taaacggagg agcgcaagaa gctgcaccgc aagaaacagc tgcaccacaa 1377181 gaaacagctg ctaaaccggc tgctgcacca gctccagagg gcgaattccc agaaacacgc 1377241 gaaaaaatga gcggtatccg taaagcaatt gcaaaagcga tggttaactc taaacacact 1377301 gctcctcacg taacgttaat ggacgaagtg gacgtaacaa accttgttgc acatcgtaaa 1377361 cagttcaaac aggttgctgc tgatcaagga atcaagctga cttacttgcc ttacgttgta 1377421 aaagctctta catctgcact gaaaaaattc cctgttttaa acacgtcaat tgacgataaa 1377481 acagatgaag tcatccaaaa acattacttc aacatcggta tcgctgctga cactgaaaaa 1377541 ggcttgcttg taccggttgt gaaaaatgca gatcgtaaat ctgtctttga aatttctgat 1377601 gaaatcaatg gccttgcaac aaaagctcgt gaaggcaagc ttgctccagc tgaaatgaaa 1377661 ggcgcatctt gcacaattac aaacatcggt tctgccggcg gacaatggtt cactccggtt 1377721 atcaaccatc cagaagttgc gattcttggt atcggacgca ttgcagaaaa agcgattgtt 1377781 cgtgatggcg aaatcgtagc agctccagtc ttagctcttt ctctcagctt cgaccaccgt 1377841 atgatcgacg gagcaactgc gcaaaatgca ttaaatcaca tcaagcgttt actgaacgat 1377901 ccacaattaa ttttaatgga ggcgtaatgt tatggtagta ggagatttcc ctattgaaac 1377961 agatactctt gtaattggtg cgggacctgg cggctatgta gctgccatcc gcgctgcaca 1378021 gcttggacaa aaagtaacag tcgttgaaaa agcaactctt ggaggcgttt gtctgaacgt 1378081 tggatgtatc ccttcaaaag cgctgatcaa tgcaggtcac cgttatgaga atgcaaaaca 1378141 ttctgatgac atgggaatca ctgctgagaa tgtaacagtt gatttcacaa aagttcaaga 1378201 atggaaagct tctgttgtca acaagcttac tggcggtgta gcaggtcttc ttaaaggcaa 1378261 caaagtagat gttgtaaaag gtgaagctta ctttgtagac agcaattcag ttcgtgttat 1378321 ggatgagaac tctgctcaaa catacacgtt taaaaacgca atcattgcta ctggttctcg 1378381 tcctatcgaa ttgccaaact tcaaatatag tgagcgtgtc ctgaattcaa ctggcgcttt 1378441 ggctcttaaa gaaattccta aaaagctcgt tgttatcggc ggcggataca tcggaactga 1378501 acttggaact gcgtatgcta acttcggtac tgaacttgtt attcttgaag gcggagatga 1378561 aattcttcct ggcttcgaaa aacaaatgag ttctctcgtt acacgcagac tgaagaaaaa 1378621 aggcaacgtt gaaatccata caaacgcgat ggctaaaggc gttgaagaaa gaccagacgg 1378681 cgtaacagtt actttcgaag taaaaggcga agaaaaaact gttgatgctg attacgtatt 1378741 gattacagta ggacgccgtc caaacactga tgagcttggt cttgagcaag tcggtatcga 1378801 aatgacggac cgcggtatcg tgaaaactga caaacagtgc cgcacaaacg tacctaacat 1378861 ttatgcaatc ggtgatatca tcgaaggacc gccgcttgct cataaagcat cttacgaagg 1378921 taaaatcgct gcagaagcta tcgctggaga gcctgcagaa atcgattacc ttggtattcc 1378981 tgcggttgtt ttctctgagc ctgaacttgc atcagttggt tacactgaag cacaggcgaa 1379041 agaagaaggt cttgacattg ttgctgctaa attcccattt gcagcaaacg gccgcgcgct 1379101 ttctcttaac gaaacagacg gcttcatgaa gctgatcact cgtaaagagg acggtcttgt 1379161 gatcggtgcg caaatcgccg gagcaagtgc ttctgatatg atttctgaat taagcttagc 1379221 gattgaaggc ggcatgactg ctgaagatat cgcaatgaca attcacgctc acccaacatt 1379281 gggcgaaatc acaatggaag ctgctgaagt ggcaatcgga agtccgattc acatcgtaaa 1379341 ataattttca tatcaaaaac agccccgctt tgagcgaggg ctgttttttt attttgacag 1379401 cacatgctgt aatggtttaa tgatgtcttc tttctttttc acacatccct cgattttcac 1379461 cacgacatgg cgctgatcaa caaccataag ggtagggaca gtttcaatct catcttccca 1379521 gccttctttt ttatcataga ccttcatttt atctatttgc tcgggataat ctttttctaa 1379581 atcaagcagt gcatcgtaat aaggcgcttc ctggtctatt tggttctcat cagaaaaaaa 1379641 caggatttgt gtatgatgaa tgttgtcaat ccggcttttt ttcatcggat tgatggtgga 1379701 aagcgtacag cccgataaag caaatactat tatcagcatg gggaataccg cgcgatatcg 1379761 catctatctt ctcctctgta taaacagtag ttaactagct ttagtttatc acgagagacg 1379821 gcttaatctg cttcttgtta cctaattgtt atataattga aaccgttttt aaagtgagat 1379881 tacatattat atcaatcgtt taaaatagca acctggggta tattgaattt tttgctgcat 1379941 tcttggatga aagttcaaga aaacgtgcaa ttacattatg tgctgtggca tatatatcga 1380001 gtaaagcttc tgtatgaaga agatattgta tgatggaaaa tggaaaaaca aggtgaatat 1380061 gatgatatga aataaaatgt gttatacagt ttgttgttga cattttaaat gtgacatatt 1380121 aatataataa caacaaaaga aattaagcgt tttcaaattt caaagaaatg gggaataaga 1380181 gatgggtacg attgtttgcc aagattgcaa cgaagccatt cattactttg aagatgagaa 1380241 agtgacaaca ttatatggaa cttgctgcgg acaatgtcaa tgtcctgttg atgaagagta 1380301 aaaaaaagca tgcggcttaa agccgcatgc tttttatttt ttattgaatt gctttttgtt 1380361 ctttgatgac ccggatcata tgtaaagtcg agtcctcagg tccttgaaca gggaggcctg 1380421 cgtcaaggtt tttaaaaatg tagctgatgt tttcttctgt aataatttct cctgggatga 1380481 agattggaat accaggcgga tataccatga caaattcagc aataatccgt ccggatgctt 1380541 cttttaatgg gatgacttcc gtatttgcat agaaagcatc acgcggagtc attgccaata 1380601 aaggtatttc tggaagcaga acctcagttt gctgatgtgt tacatcttgt tctgacattt 1380661 gctgtgcgat ctcagttaaa gcctctacaa gccggtctgc atcattttgg ctgtcaccag 1380721 gagtgaaaat acacaaaata ttgtacagat cagaaagctc cacctcaata ttaaaggatt 1380781 cacgaagcca tttttccacg tcatgtcctg tcaggccaag acttttcaca gagataatca 1380841 attttgtcgg atcatagctg taagctgctt tcgacccaag aatctcagaa ccgacacaat 1380901 aaatgccttc aatctgattg aggcgatctc tcgtctgatt ggcaagcttg agtgtttcct 1380961 cagcaagctg gcggccttct gttgcaaggc gttttctggc aacatccaaa gaagcgagaa 1381021 gcaagtaaga agttgacgta gttgtcagca tgctcaggat ggattgcact ctgtctttag 1381081 atacaaggcc ttctctcatg tttaaaatag agctttgtgt cagtgatccg cccagcttgt 1381141 gtacacttgt cgctgctatg tccgctcctg cctgcatagc cgatagcggc aattcgtcgt 1381201 gaaaatgaat gtgaacgccg tgtgcttcat ccacaagcac tggcacatca aacgaatgag 1381261 cgagttctac gatgcttttt aagtcggctg caacaccgaa atatgtcggg ttgatgacga 1381321 gaagcccttt tgcatccgga tgctcggtaa gcgcccgttt agcagattca agtgtaattc 1381381 cgtgggagat gcccaattca ttgtcaattt caggatgaat aaaaattgga accgctccgg 1381441 aaaatacaat agctgtcata attgatttat gaacatttct tggaataata attttatcac 1381501 caggtccgca aacagccatt accattgtca taatggcgcc gcttgttcct tgaacagaaa 1381561 aaaatgtatg atccgctcca aatgcttcag cagccagatc ttgtgcttgt ttaataatgc 1381621 cttttggcgc gtgcagatcg tctaatggtt caatattaat caaatctatg cttaacgcgt 1381681 tttcaccgat aaattgtctg aattctgggt ccattcctgc ccctttttta tggccgggaa 1381741 tgtggaattg aacaggctgt ctgcttgcat gctttttcag tcctgtgtat aagggtgttt 1381801 catgttgcga caattgtttt cccacctttg taatcatacc tatgcataat agtgtgtatt 1381861 aaaatcagtt tctcaaccgt tttttagacg taaaacaaat gaattatatt atgaacttga 1381921 aagaatgtaa agaacaattt atgatcaaat gaagatgctt tctcttaagg gaagtaaatc 1381981 tacaaggagt gaagaaaatg gagtatcaat atccgatgaa tgaagattgg acaaccgaag 1382041 aagcagtgga tgtgattgca tttttccagc aggttgagct tgcatatgaa aaaggggcgg 1382101 atcgtgaaga actgcttaaa gcttaccgcc gtttcaagga aattgtaccg gggaaggccg 1382161 aagaaaaaaa gctatgcggc gagtttgagg aacaaagtac atattctcct tatcgcacgg 1382221 tcaaacaggc gagagaatct gatcacgcga agattaagat gtaagaaaaa gagccggggg 1382281 atatcccggc tcttttttat gcttgtgtta ctttttgggt gagacggtac agaaaagcaa 1382341 gctgtttaaa ggcatcgtcg atacgctgaa ggaattcctg gttattcata ttcagcactt 1382401 cttctttttg gagctggatg ccgcataaca gctcggcttt ctttacagtc tgcaaacgct 1382461 caaacagtgt cttcagctgt tccttgtcca tttcagactg tttatgtact cccggttttg 1382521 tgtgatctgc agaccaaacg aagctgtcag ggatattttt cgtaatggtt tcttggttca 1382581 cttcaagcaa tttgccgtat tcttctttga taggggattc ataaataatc gcgaaccata 1382641 caaagacgtg gctttcccat aaaccaattt ggaaatgcgg cagtttttta tagcctcttt 1382701 tgctgtttgc gaacgccacc cagctgtcag ccgggggatt gacggatctt cttgcgtgct 1382761 ttgccacatg cggaaacatt tcatctccgg ttaaagctga taaagttggg gcaaaatgtt 1382821 cgcctagagc tgtaagcttc ggacggaccg tctcttttaa tacttccatg cgcgcgtcta 1382881 agccttctat tgtaaatgtg ttaaagtctt cttcagtgaa acgcatttgt gtcatgattt 1382941 tcctccttca tgctaagtat acatatttta tcacagttca tacgagcttc aaaaagattg 1383001 agcgcgtttg aagtaaggag aaatgtggta ataaacgagt aggtaaacac acaattttca 1383061 gaatcatgtt gcgcgtaaat agaacaatca tacgatataa gaagtaatca ttgttgaatg 1383121 gcaaaatggg atgctttttt acaaacaaat gatctctgga aggggcgaaa gacaatgagg 1383181 caagttgtaa aagagggatt taaggaagag aaaaacaatc gtgttgctgt ctggagacta 1383241 gaggttgatt atgaattggc aaccctatat gaagcaatgc agaaagaaaa tgaagagcag 1383301 attgaacaaa gcaaaaacaa acttgagcga cttagaaaag aatggattcg tcttaacggg 1383361 taaaaaagcg atagtgaaaa cgaaccgcat gaatggttcg tttttacgtg agaagggata 1383421 tttttcattt tccttgcttt ttcattgccg ttatcagtat cctataaaat aaaaggtcta 1383481 catagaagag aggtacgaac gaatgacaaa ttggacggaa atcgatgaga ttgcaaagaa 1383541 atggataaga gaagcaggcg cgagaattac acaatccatg catgaaagcc tgacaattga 1383601 aacgaaatca aatccgaatg atttagtcac caatattgac aaagaaaccg aaaagttttt 1383661 cattgatcga attcaagaaa catttccggg acatcggata ctcggtgaag aggggcaagg 1383721 agacaaaatc cactcacttg agggagtcgt atggattatt gatccgattg atgggacgat 1383781 gaattttgtg caccagcaaa gaaattttgc gatttccatt gggatttttg aaaacggtga 1383841 aggtaaaatc ggtttaattt atgatgtggt gcacgatgag ttgtatcacg catttagcgg 1383901 cagaggagct tatatgaatg aaacgaagct ggctccatta aaagaaaccg tcattgaaga 1383961 agcgattctt gccattaatg caacatgggt aacggaaaac agaagaattg atcaaagtgt 1384021 gttagcgcca cttgtgaaaa gagtcagagg cacacgctcc tacggttctg ccgctttaga 1384081 gctggcaaat gtcgcggcag gaagaataga tgcttacatc acgatgcggc ttgcgccatg 1384141 ggactacgca gccggctgtg tgctgttaaa tgaagtagga ggcacctata cgaccattga 1384201 aggagagccg tttacctttt tagaaaacca cagtgtgcta gccggaaacc catctataca 1384261 taaaacgata tttgaagagt atcttcatgc tcggaagtag gccatttgag caggatgatc 1384321 tcagcttgtt agaaaagctc gcggaggctc atcctgtatg gaaagaggag gagtttggag 1384381 ataaagatgc agaagactat atcatttcct actccatgta caacggttca tggcttgtat 1384441 gggaaaaaga cggtatgcct gttgccgtca gctaccatct cgagtggtct ccttcaaacg 1384501 gtaagccgtg gctcggaacg gtcctgattg acccggctga agaaaaaaag ggacatgcga 1384561 agatgatcat tgaacagatc agcaaattgc ttagagcgaa acataaagcg atgtttgcgg 1384621 gagttcccat tgagcgcagg gaatggatac tgtttttaag ccaatgcggc tttgaacagc 1384681 tgaaaacgga aaaagatgag aaaggcaaat catttatgat cttggtgaag cctttagcag 1384741 aagctgccgt atgataatgg cagcttattt gctgcatgcg ggttcaataa aaagcctctc 1384801 aaacattgag aggcttctga tgatttgaaa attatttttt taccgcatga atataatgaa 1384861 tcgtttcaaa cgctgacaaa ttgtcttttc gattactaaa gaaaaggtca ttgatgtcgt 1384921 ctggtgatag atgttcatag atcagtaaac cagatgactc taacagatgt tcaatctctt 1384981 gataagtgaa acatgatttc atcggttccc cgcttgcggc agccatcttc accatatgtt 1385041 caactcgatt cgacgtccct tttgctgtaa aaagtgtttc gtccgcataa tcaaaaacaa 1385101 tagagcttcc aggcgggaca tgagaaaata aattgctgat caagcttgca ttttcttccc 1385161 gtgttacata ataagacact ccgagaaggc tgaagaatgt ttttgtgttt ttaaatcctt 1385221 catctaagag aggatcatac gaaaacgttt tggtgaaatc cataggaaca aaatgaagat 1385281 gacccggaat tgtcagattt gcatccttca gcttattttt tttcaattgc tgtgtggccg 1385341 gatgatcaac ctcgaaaacc tgtaagctgt tttctaattc tggatgccga aagcagaaag 1385401 tatccagtcc cgctccaaga atgacatact gttttgcccc caggattaat tcgttgtgca 1385461 agactttttc acaataagaa gcacgtgcta ggggcgttgg agacagctgg atttgtgcaa 1385521 cccattttaa tattttttca ggatcatttt gaagacgttc ggcgatctct ttgttgaaaa 1385581 acgatatttc ttgaatcata tttttactga tgtcgataaa ctctttttcg ttaatgagat 1385641 cttttgcgat aaaatcatca aaaataagag gtgtgtcata tcggctgtga tatgcacggg 1385701 caaaagctga aattagagac gttaagctgg actcattttt cctcatgaaa tgatcctcca 1385761 caaaaaataa gattcccctg gccaggagaa tcttattata catacaaata tattaatagt 1385821 aaattttagc ataaataaat ttttttgtca atgtttttgc tcttaactgg acgcgcgatc 1385881 cttcacatag ccacgtgacc tgtagcagaa ttcgtctatc aattatgtgg actgaatcat 1385941 tagcttttat aaaatgcgca cttgcggctg catccctctt tatgcaaatc aggagcggtt 1386001 ttctgtctca tggcagcatc ttttcgtcgt ttcagctgag agagaaatca agatatgtaa 1386061 caataaaagc ctgagggatc tcaggctttt cctaatatta caatccaaca gcattccagg 1386121 ctgcttcaac tttagcggca tcagttgagc cgtagaggtc acgggcagac tgaatgagag 1386181 ctgccttggc atctttgaac gtggaagaag gcgtgaggta cgttgttaac gcacggtaat 1386241 agatttgctg tgatttagat acaccaagtt ttgtgatggt gttgtaagcg gctttgtttg 1386301 gaattccgct gtttgtgtgt acaccgccat aatcgccttc atctgtgttt ggaaggtttc 1386361 ggtaattggc gtaattgtca ggctggttgt attttgtagg gttggacagg ctgcgaagag 1386421 caggctggct gaccgtaatg tcttcaccga tgtcccagtc ttctgtatcg ttaaaatacc 1386481 cgaatacgtc agagaaagac tcgtttaatg cacctggctg attttcataa atcaagttgg 1386541 ctgtttcttg ggtgacgcca tgtgtcattt catgcgctgt cacatctaat gagccggaaa 1386601 gcggagagaa gaatgaaccg tcgccatcac cgtaaatcat ctggtctcct gtccatgcag 1386661 cgttattgta ttgagtgccg tagtgaacgg aagaaacgat tttactgcct ttgttatcat 1386721 agctgtttcg tttaaagttt gaataaaaat aatcgtacac tttaccgagg ttatagtgtg 1386781 cgtcaacggc tgcccgctgt gatgaagatg taaatgtttt cgttgtgctt gagacaagcg 1386841 tgcccggaag gcggctttgt ctgttttgca aatcatatgt gatgatttgg gtgcctgttg 1386901 gttttgaaag atctcttaga acatattttc cgccttcata agagatgttc aaaggaacag 1386961 ttgcgccctt tagcgttgtt ccgcttccag tggcggcggc atgttctact ttattttgct 1387021 gttttaaaat gctgcctgtt tcggcgtcaa ctaagacttc ccagtttgca ggttcaggct 1387081 cgacatagcg aatcgtcacg tcgtaagcaa gacgatagct gccgtctttt gtttctatcg 1387141 cttttaattc ggctttattg ctgtttttgg ccgctccgtt agaaacagcg tctggtgatt 1387201 tgccgatagc tttgaaagcg agtgccagcg ctttttcaga agagactttt tggctgttat 1387261 ctgtttttgc agcagattga ttgtgtaatt caccattgac cgcatagaca ttatcggatt 1387321 tatcgacgtg aacgatcact tgcgaatctt taattggcac tccgttaacg acaggcgcat 1387381 atcgaaagtg cttgtatcca agggcatcag tcgtgctttc aacaagcttc agccttttgg 1387441 aagggtcacc tttaaaaatg ttgctgttct ttttcaaaaa ctgcttgaca gccttgtcat 1387501 ttggtgcaga gagttctgat tgcgcaatcg cgtttttgga gaggaaattt gtttgattct 1387561 ctttaagctg atgaccttca gcagcctgaa cacctggcag gctgattgat aaactcataa 1387621 acgaagcagc gacagcaaca gacaatttct tacctaaacc cacaataaat cccccttttt 1387681 gaaaatactg aaaactttat attgttatat taaactagca ttctggaata ctcaacaaaa 1387741 actaacataa ctagacaaaa ttgatagtat tgtcctgtgt ttgtttttgt tgaataatat 1387801 caagatgagt caagtgtcat gtggtggttc attcaagagt tatgtttttt acatatcaag 1387861 gggaagatga gatatttttg tttcatcttg aaactttttg aaaagtccgc tgtctaaccg 1387921 aatgaggcct taataagaag taaaggattg ttgttcgtgt tggagttatt cagtcattat 1387981 gtattgcatt tcgaacgtta ttttatatta agcagacaaa gcaccctgct gattcaatgg 1388041 tcaattgttg ttctggcggg cttatatctt ttggtgcatc atcccaaaat aaaccggcag 1388101 cgcacaatgt tcttggcggg tgttatattg cggattgtgc tgctggcggg agtgtctgtt 1388161 gaacttattc accaggtgca atcaacaaac ttcaccagcg cttacttaag agaggacgga 1388221 aaagaactgc tgccgctgct gcattttttg ttatacggat atgtgctgct gacggctttt 1388281 cactatatgc tgatgccgcg tgatcatggc ggaaagggta agttttatac gttcgacctt 1388341 gctgttgtca gtttgccgat cgtacaaatg atttttagtt tcttttcgta ttggaaggaa 1388401 tacccggatg ggatggagcc gattgcattc gtgtttctgt ttttcatcat cactcttccc 1388461 attgcgttga atgtagtgtt tttcaagctg tattggagaa cggataagat cttactaggc 1388521 ttattttata cgctgattat cggactgctt gtcttgctgc ttgcgccata tcccaatcaa 1388581 atctcaaaag attatggtgc agtaatgcca tatacgattt atttggcaat ggcgggattt 1388641 ttgatgagct atcatctgtt ccaaaagtca ggaaaggttt atgtgcgtgt gaataagtgg 1388701 gtgacgatgg ctgtcatggt gttttttgtc ctgctgttaa atccgatata taacatagga 1388761 acggctgctt tcgctgtatc aaagccagca aatgtccatg attcattcaa ttttgtcggg 1388821 gagcacattt catcagaaaa agcggaacag atactaaagt cattttttcc tacggatgaa 1388881 acactttatt tgcacgatac aaacatggat gtgcattatt tctactcatt tgaaagcaaa 1388941 ggttacaaag ctgaggtaga tgaagtatcg cagctaattc gtaattatga atacttacaa 1389001 aaagcacatg ggaaaaagct aacgaatcag gagtacaagc gaaagtccat cgctttcctt 1389061 gagcgacacg gacgtgtgtt acataaggat catatcgaaa caaaggtatc tcaagaagac 1389121 ggccagacag tcgtacgtat ttacctgaaa aatcaacttc ataaaaaaga tcatgctgat 1389181 gatggcgcgg tattttattg ggaaaaggaa accttaatgg ggtttagtga agatccttcg 1389241 atttatcagc ttgactctct tctgcatgtt catataacgg aacaagacat tcacgacaaa 1389301 gtggaacaaa tgtttacagc gctgaacata tcaaaacagc cttatcagat cactgatatt 1389361 gaaagcgaca gcctgcttgg aagcatggtg agagttgaaa caaaagttgg aattgttttg 1389421 gaatttgagg gcgaatcagg ttgtttacat agtctttcgc ttccgatgaa aaagaatatc 1389481 tcaatggcta acagccggct gcagcatcag atattatcga tcttcgatgc tcgtggatca 1389541 gaaaagaaga aaaaaagcag tcagggtgac atggtgatgt atactgattc ttctaaaaca 1389601 tatgagtttg ttgaagctca aggtcagcta aacgtttatg tatacagcga tacacctgat 1389661 cagtcattcc cctatacgta tcgtaatgga acattggctt acgaaaaagt agcttctcta 1389721 tatcaggatg tcatttacaa aaagcgtatg cgtccgatta tcgttcaaag aggggatgaa 1389781 cggcattatg catggctgat cattattcag ccgtttggtt caaatcgcca tgatgcctat 1389841 gtagtggatg gagaaacaca agaggtgaaa agtctttatg aatcataaag aaaaagagtc 1389901 tgtttttgta gacttatacg acctgtataa agaaggagag ctagaggatg aatcaatgga 1389961 atggatgaaa cagcatgaat ccctatttca aaagaatgcg gaagacttaa agagtaaaac 1390021 ttgtttaaag agaagtcccg gtgctgaaga agaaagccaa atcagatata tgaaagtata 1390081 cctgtcttcc atgtatatct gtttcatttt attggccatt tggatgacgg tgtggtttta 1390141 tttttaatga agcataggga ttccattgag gacttgtatc ggcagtatta tcaagaaatt 1390201 ttaaattatt tattcagaag gactcatcat cttgaaacag ccaaggactt agcgcaggac 1390261 acgtttgtaa aagctcttaa cggtctggct tcgtttaggg ggcattcttc catcagaaca 1390321 tggctctaca ccattgcgca tcataccttt atcaattggt accgaaggga tgtcaaatac 1390381 caatttactg aaatcagcaa aaatgaaggg ttaacgcaaa caacttatga ccagcctgaa 1390441 cagtatctgt cacggacggt gaaaagcgaa acactgcggc aggagctcct gaagttaaaa 1390501 gatcagcatc aatccgtttt gattttaaga gaattccaag agctttctta tgaagaaatc 1390561 gctgagatat taggatggag tctttctaag gtgaatacca cattgcaccg ggctagatta 1390621 gagctaaaga aaaacatgac gaaaagtaga gaggaggagc ggatatgacc tgctttctag 1390681 taagagacct gcttcctctg tatcttgaag gtgattgtaa aagagaaacg gaacacgtta 1390741 tagaagagca tttaaaaatg tgcagcagct gcagagacat gtatgacacg atggctgagc 1390801 catttgaatt ggaaagcgaa caggccgttg aggaggctta tctgccggaa gaagaactgc 1390861 gttttaaaca gaggtactat ggattactga tcatgaaagc tgcctgctgg tttggagcgg 1390921 cggttgccat gatgctgatc atcaaactgc tgatataaaa aaagcgcttg tccgattccg 1390981 gcaagcgctt ttttacatta agcctgggga tgaatcatat cgtaaatagc ggcaagctgt 1391041 tcttgtgaca gggcactgaa gagtttttca taaacgtcag cttgcagtgg cgttgcacct 1391101 gcttgtagcg ctgcgtcttt atcatagctg tacacatcat cttgtagcac aatggctgct 1391161 tgaagaatgt gaatcttgag agaaacagcg gagaaaaatt gttcaagtgc aagtgcttct 1391221 ttttctgtga agccaagttc aactgctttt tctgtatcaa atttgtaatt tccatcctcg 1391281 agatacacac attgtgaaac aatgctgaaa aattctgatg tcgattccca gagtgtagca 1391341 attacctgag cctcttcttt tgtcattcct aactcgacag ctttttcgct gtcaaaataa 1391401 tatacaccgt cttgttcgta tatacattga tttaatatat caatgaatgt attgagatct 1391461 tcgttagtgc tcgcctgatg ctggagttga acagcagtgt tatcaaccgg tgtttttgcg 1391521 ctggctgcat caggaccgaa cgttaataga gcagctgagg tcattgcggc agtcgttaac 1391581 atagcttttt ttacaaatgt tttcttcatg tttcttctct cccttttatg aattgtgcta 1391641 caaattccat tatagggagt agtttccggt ggaggaatag gcgctatggt attttatgtg 1391701 tatcgttgcc gaactacttt ttgaaggctg cacgtgtgat cgttagaacg attgtctatg 1391761 tatgaaggct gttttgcatc ttcctgacta agaaacaggg gagataaggc ttaaagaaat 1391821 gaaaaacacc gctttctttg cggtgttttt tgattacaat gtcgccggcg gggcaatgct 1391881 tttaatcaag caagccttgt tcgcgcattt tcttttttaa tgtaaatccg ccgcccatga 1391941 cagcgcaaac aagtacaatg ctggcgataa tgcctgcagg gcttttttca gcgataaaga 1392001 cgccgatcag cataatgctg aaaaccgctg caaatgcaaa taatagtaaa agccaattca 1392061 tttttttcat aaattccatc cccttttacg tcttatatta agtttacaga aaaacgtgac 1392121 gcttttaaag aggatgtgtg atataatatg aaagttatct aattttttta ggagatgaaa 1392181 aagtgaaact tcgaaatgat cttcgcaaca tcgcgattat tgcccacgtt gaccatggga 1392241 aaacgactct agtcgatcag cttttacatc aggctggtac gttccgtgcc aacgaacagg 1392301 ttgctgaacg cgcaatggac tctaatgatc ttgaacgcga acgcggcatt acaatattgg 1392361 cgaaaaatac tgcgattaac tataaagata cacgtatcaa tattttggac acccctggac 1392421 atgcagactt tgggggagaa gtagaacgga ttatgaaaat ggttgacggc gtagtgcttg 1392481 tcgttgacgc atatgaaggc tgtatgcctc aaactcgttt tgttctgaaa aaagctcttg 1392541 agcaaaacct gaaccctgtt gttgttgtaa acaaaattga ccgtgacttt gctcgtccag 1392601 aggaagttat cgatgaagtt ctggatctgt tcattgagct tgatgccaat gaagagcagc 1392661 tcgagttccc agtggtatat gcttccgcga ttaatggaac agcgagtctt gatccgaaac 1392721 aacaggatga aaacatggaa gctttatatg aaaccattat taagcatgtt ccggcacctg 1392781 ttgataatgc agaggagccg cttcaattcc aagttgccct tcttgactac aacgactatg 1392841 taggccgtat cggaatcgga cgcgtattcc gcggcacaat gaaagtcgga cagcaggttt 1392901 ctcttatgaa gcttgacgga acggcaaagt cattccgtgt tacaaagatt tttggtttcc 1392961 aaggcttaaa gcgtgtggaa attgaagaag caaaagcggg agacctcgtt gcggtttccg 1393021 ggatggaaga tatcaacgtt ggtgaaacgg tatgtcctgt agaccatcaa gatccgcttc 1393081 cggtccttcg cattgatgag ccgacacttc aaatgacatt tgtcgtgaat aacagtccgt 1393141 ttgcaggccg tgaaggcaaa tatgtaacgg cccgcaaaat cgaagagcgt cttcaatcac 1393201 agcttcagac ggatgtgagc ttgcgtgttg agccaacagc ttctcctgat gcttgggttg 1393261 tttcaggacg cggtgagctg cacttgtcaa ttttaattga aaatatgcgt cgtgagggct 1393321 atgagcttca agtgtcaaaa cctgaagtta ttatcaaaga aatcgacggc gtacgctgtg 1393381 agcctgttga acgtgtgcaa attgatgttc ctgaagagca tactggctct gtaatggaat 1393441 caatgggtgc ccgcaaaggc gaaatggttg atatgatcaa caacggaaac ggccaagtcc 1393501 gtctcatctt tacagttcct tcccgcggat tgatcggtta ctctacagaa ttcctatcat 1393561 taacacgcgg attcggtatt ttgaaccata cgtttgacag ctaccagccg atgcaggcag 1393621 gccaagtcgg cggacgccgt caaggtgtac ttgtgtcaat ggaaaacgga aaagcaacat 1393681 catacggtat tcaaggaatt gaagaccgcg gtgtcatctt cgttgagccg ggtactgaag 1393741 tatacgaagg aatgatcgtt ggagagcata accgtgacaa cgaccttgtt gttaacgtca 1393801 gcaaaatgaa acagcaaaca aacgtccgtt ctgcgacaaa ggatcagaca actacaatta 1393861 aaaaagcgcg catcatgtct cttgaggagt ctctagagta cttaaacgaa gatgaatatt 1393921 gtgaagtaac acctgaatcc atccgtttaa gaaagaagat cctcaataag aacgaacgtg 1393981 aaaaagcagc taaaaagaaa aaaacagcag gattgtctta atctcgtgca gaatttgaaa 1394041 agatagaacc cgtacgttta caggggaggg aatctttttg aatgacgtaa gcgaacgcct 1394101 gtcgttcttc gccgctctat atcaagtaga ccggcagcct gcggcaggca tgtggctgct 1394161 gtacggcacg atttttgtgt tggccgttat tgtatttaag cttggatttg ctaaacggct 1394221 tcctgtatta aaatctgcag tggtgtatgt atttttggct ttgggctgca ctgttttgac 1394281 ttttttaggg gtgtttttgc ccgtggcaga aggattggtc gtcgctgcgc tgattttaat 1394341 catttacaaa atccggctgt atcagtcgaa aaaaggacag tctgcaaaat cataaaagac 1394401 tcagctgaaa gctgagtctt ttttgtgttc tgtatggtta agcggccgct ttattttttg 1394461 actttttctt ttttctgctg tcccgggtga aaagtaaatt ttcccgtttt cagccgttcc 1394521 tctgtttttt tggcaatccg atcgtggcat tcctggcaca tatatgtatg gatcgggcgg 1394581 tttcgaagcc gtttcgcgat cagggtatca tcatcaattg tttcaatttt atcgcaaata 1394641 gaacatttga ccctcatcat atcacctctt tcactaacat gtattatacc acggatcaga 1394701 agctgtccaa aataagaaaa agctaaagcg caaggctata gcttagtcat tgttgttctt 1394761 tttcatatga tgatcagatt gatcgttttg ttccttctcc atttcctgtt gctgttttct 1394821 atttaattgg tcattttgct gctttgtttg cggttcatct tcattgtcaa tcacatcgtt 1394881 aggcacttcg ggaagcactc ggccgacaat tgcagctaat tcatccagta tacctgttac 1394941 cggatggccc tcgctgattt ctctgctcat ttcgcgaagg cggctgaccg tatcgggatc 1395001 agcaatgact actgcgttgg cgccatatcg atcattcttt agcgcctgag ctacagaata 1395061 tttaatggtt tccactttgc ttctgtccaa agtatcatcg acatcaatcc caacaacagc 1395121 atagcctccc agcacaacgg ctgttgcatc cttgacgtcg gggttttttt cagcaacgct 1395181 gacaagatgc ttggcaatat ccgttcttgt tccattgtct tttgtttctt gagttgtgtc 1395241 ctttacgtga atcggtttag tctcctgctg tcttgttgat tctttttcaa cattctggcc 1395301 ctgttttcct tgttgatagg cacaagcgga caggataagt gtcagctgta tgataatgaa 1395361 aagaattcgc acttgcgggt tccctcctta aaatgctttc attaatttta ttgttgaatt 1395421 aaccttctat ctttatgcac aaaaacatat attttagcag gcattcacct ttttcatcaa 1395481 aagagaagca ggaagaactt tgacccttat atcaggaggc tgagacttga gtaaaattta 1395541 tgtgttagat acgaatgtgt tattacagga tcctaacgcg atattttctt ttgaagaaaa 1395601 tgaggttgtc atccctgctg tcgttttaga agaggttgat tcaaaaaaac ggtatatgga 1395661 cgaagttggg aggaatgcaa ggcacgtatc taagctaatc gatgcgctaa gacaaaaggg 1395721 caggctgcat gagcatgtac cgcttgacac cggcggcaca ctgagaattg aactgaatca 1395781 tcgttcgttt caccagctgc aagagatctt tattgaaaag acgaacgata atcgcatatt 1395841 agccgttgcg aaaaacttaa gcctcgagga agaaaccaag gaaaatggca ggccggttat 1395901 ccttgtcagt aaggatgtac tggtcagggt taaagccgac gcaatcggac tgcttgctga 1395961 agatttcttg aatgaccggg ttgtggacaa tgatgaaatg tacagcggct ataaagattt 1396021 atatatcagc cagcagctgt tcagctcttt ttacgggaaa aatcaaattt cagtaaacga 1396081 tgtgaaacag catgcgtttt atccgaatca gtttgcttta atgaaggatg agctaggagg 1396141 gtcctcctcg gcagtcggaa ttgcagacaa aaccggaacg gtattaaaaa gactcgtatt 1396201 tgatgatgaa catatatggg gaatcaggcc gaaaaatgta cagcagacaa tggcattaga 1396261 gcttttgctg cgggaagata ttccgcttgt caccctgatc ggcaaagcgg gaaccggcaa 1396321 aacgctctta gctttggcgg cagggctatt acagacagaa gacttgggaa tatataaaaa 1396381 gctggtcgtc gcaaggccga ttgttcctgt tggcaaggac atcgggtatt tgccaggcga 1396441 aaaagaggaa aagctaaagc cttggatgca gccgattttt gacaacttag agtttctgtt 1396501 taatgcgaaa aaaccagggg agcttgatgc tattttggcg ggaattggct caattcaggt 1396561 agaggcgctg acttatatca gagggagaag cattccagat caatttatta tcattgatga 1396621 agcgcaaaat ttgaccaggc atgaggtgaa aacgttgctg acgagagtcg gtgagggcag 1396681 taaaattgtc ttaatgggcg accctgaaca aattgatcac ccatatttag acagtctgaa 1396741 caatggtttg gcctatgtgg ttgagcggtt taaaggacaa cccatctcag gcagcgtgaa 1396801 gctgttaaaa ggtgagagat caggtctcgc ccagcttgca gctgatttgc tgtaacactt 1396861 aaatgatttc gatctctttt acatcggtaa tcggctgttt gtgatgaacc gggtcttcaa 1396921 agtaaatatg cacggggccg ccttcttgaa tcggcttgcc tgcctcactg aaatggacaa 1396981 tactgttcag agcggtttcc agagaaacgg cggcctttcc cgaacttgtg acaaatacac 1397041 attgtgtcgc agagctgttc ggctcagcat ttttcaggac agtcccaagt ctcattgcga 1397101 aactgccgtt catcagtttt tgcttctcat attgcttttc cgtctttaat gtaggcggcg 1397161 cgattcgccc ctctctgatg acgcgttccg gatcaaggtc ggattcatcc ccggctgatt 1397221 gtaaatatgt gtcttgactg tcccctttgc ggtcaaacga aaatttgcga tcatcaaaaa 1397281 tccatacgct tggatcaatg gtaattggat atgtaacatt gccttttact tggataacgc 1397341 tcatgatatg acccccttct ctcaaaatta taaaagtttt cgcatgaatt gtcactttgt 1397401 gtacaaatta tgtgtattga aatgctgagg gaacgagggt gtttgcatgg tatgccagca 1397461 taatgatgag cttgaagcct tagtgaaaaa ggcgaaaaaa gtaacggaca agggggaggt 1397521 agccagctat attcccgcct tggcaaaagc tgataaacac gacctgtcag tggcgattta 1397581 ttattccaat aatgtttgtc tgtcagcagg tgacgtagaa aaaacattta cgcttcaaag 1397641 tatatcgaaa gtcctttccc ttgctttggt gttaatggaa tacggcaaag ataaggtctt 1397701 cagttatgtt ggacaggagc cgaccggtga tccgtttaat tcaattatca agctcgaaac 1397761 agtgaatccg agcaagccgt taaaccctat gattaatgcc ggggcattgg tagtgacaag 1397821 tctgataagg ggaagaacgg taaaagagag acttgattat ttgctttctt ttatcagaag 1397881 gctgacaaac aaccaagaga ttacatactg ccgggaagtg gctgaatctg aatacagcac 1397941 ttcaatgatt aatcgggcga tgtgttatta tatgaagcag tacggcattt ttgaagatga 1398001 tgtagaggca gtaatggatt tatatacgaa gcaatgcgcg attgagatga acagcttgga 1398061 tttagcgaaa atcggatctg tattcgcatt gaacggcaga catccagaga ctggggagca 1398121 ggtcatctca aaagatgtcg ctagaatttg caaaacgttt atggtgacgt gcggaatgta 1398181 caatgcaagc ggggaattcg caattaaggt cggaattcct gcgaaaagcg gcgtatccgg 1398241 cgggataatg ggcatttcgc cttacgattt cgggatcggc atattcggcc ccgcattaga 1398301 cgaaaaaggg aacagcattg caggtgtaaa gcttttggaa ataatgtctg agatgtacag 1398361 gctgagtatt ttttaattta tgtcatatgc ttaaatcctc ttgcattttc tgttgatacc 1398421 ctttatgata aatagaagaa ttaggtactc gcctggggaa cggagggata cttttggctt 1398481 cagagatgat agttgaccat cggcaaaaag cttttgaact cttaaaagtg gacgctgaga 1398541 agattttgaa gctgatccga gtacaaatgg ataacttaac gatgcctcaa tgtcctctat 1398601 atgaagaggt tttagatact caaatgttcg ggctttcgag ggaaatcgat tttgctgtcc 1398661 gcctgggatt ggttgatgaa aaagacggta aagacctttt atacacattg gagcgcgaat 1398721 tgtctgcttt gcatgacgcg tttacagcta aataaatgat aaaactcaaa cttattaaca 1398781 gtttgggttt ttttataacc gctatttttc tctcatctca taaaagacgg tcttttttta 1398841 cacattcctt ccgaatcgta tagagattct tcgtctcgtt tgataaattg tagtaaaata 1398901 aaaaagataa atacataaaa accatagata atggaagtta gaagcaggga agaggatgtt 1398961 atgttaaaaa aaatgctaaa atcttatgat tactcactga tattcgcaat cgttttatta 1399021 tgcggattcg gtttagtgat ggtatacagc tcaagcatga ttacggctgt ctcccggtat 1399081 ggagtaagca gtaatttttt cttcatgcgg cagctgtttg ctttaattgc gggtggcgct 1399141 ctatttattc tcatggcgtt gtttccttat aaagcactgg cccatcaaaa gtttcagaag 1399201 gggatactgc ttgtatctgt tcttgcgctt atctcactgt ttgttttcgg gcatgttgcc 1399261 ggaaacgcgc agagctggtt taaaatcggc ggaatgagta ttcagccggg ggagtttgtg 1399321 aaactggtcg tgattttata ccttgcagcc gtatatgcaa aaaaacaaag ttatatcgac 1399381 catctgttaa cgggagtagc ccctccggta gtcatgacgc ttataatttg tgggttaatt 1399441 gccatgcagc cagatttcgg tacagccatg attatagggt taattgcgac gtgcatgatc 1399501 ttgtgctccg gcttcagcgg aaagacgctg gtgaggcttg tgatactggg cggaattgtt 1399561 ttcattttag tcagccctat tatctatttg aatcaggaca aaattttaac tgaaggccgt 1399621 ttagcgcgtt ttgagagtct tgaagaccca tttaagtatg caaattcatc aggtttgcaa 1399681 gtgatcaatt cttattatgc gatcagctca ggcggcattt tcggcctggg gctcggtgaa 1399741 agtatccaaa aatacggata tctgcctgaa tcacacactg actttattat ggctgtcatt 1399801 gctgaagagc tcggcatttt tggggtattg tttgtgattt tcttattggg ttttgtcgtc 1399861 ataaaaggtt tttatattgc cagaaaatgc gaggacccgt ttggaagtct tctggcgatc 1399921 ggcatttcaa gcatgattgc catccagtcg tttattaacc ttggcggtgt cagcggatta 1399981 attccgatta caggggttac gctgccattt atcagttacg ggggctcttc tttggtgctg 1400041 ctgctgggga gtatggggat attagcgaat atcagcatgt ttgtgaaata ttcagagaat 1400101 aagaaaaaga aagagccctt ggcgccgaag ggaatgaaaa agaaacagct caaaaaaact 1400161 gtttatctgt aaaaaacaag tgtgtacagg ggaaggatat tccgctatga tagattatat 1400221 tccattcggg taagggggag aaaagtttgt ctcagcaatc gatacaaaaa gtattagtag 1400281 caaacagggg agaaattgca atccgaatat tccgggcgtg taccgagttg aatattcgta 1400341 cagttgcggt ctattcaaaa gaagattccg gttcctacca tcggtacaaa gcggatgaag 1400401 catacttggt cggtgaaggg aaaaaaccga ttgatgctta cctggatatt gaaggtatca 1400461 ttgatattgc gaaaagaaac aaagtcgatg caattcatcc gggatacggt ttcttatctg 1400521 aaaatattca ttttgcgaga cgatgtgaag aagaaggcat cgtattcata gggccaaaat 1400581 ccgagcatct cgatatgttt ggtgacaagg taaaagcgcg tgagcaggca gaaaaagcgg 1400641 gaatccccgt gattccggga agcgacggtc ctgccgaaac gcttgaagcc gtcgaacaat 1400701 ttggacaagc taacggttat ccgatcatca ttaaagcctc gcttggcggc ggcggccgcg 1400761 gtatgcggat tgtcagatct gaaagtgaag ttaaagaagc atatgagcgt gctaaatcag 1400821 aggcgaaagc agcctttggc aatgatgaag tttatgtaga aaaattaatt gagaatccga 1400881 aacatattga ggttcaggtc attggagaca agcagggcaa tgtcgtccat ctttttgaga 1400941 gggattgctc cgttcaaaga cgccatcaaa aagtcattga agtggcgccg agtgtctcgc 1401001 tgtcacctga attaagggac caaatttgtg aggctgcagt tgcgcttgcc aaaaatgtaa 1401061 actatataaa tgcggggacg gtcgaattcc ttgttgcaaa caacgagttc tactttattg 1401121 aagtaaatcc tcgcgtacaa gttgaacaca cgataacaga aatgattact ggtgtcgata 1401181 ttgttcaaac tcagatcctt gttgcccaag ggcacagcct tcacagcaaa aaagtaaata 1401241 ttcctgagca aaaggacatt tttacaatcg gctatgccat tcagtcacgg gttacgactg 1401301 aggatccgca aaatgatttc atgcctgata caggaaaaat catggcttac cgctcaggcg 1401361 gcggttttgg tgtccgtctt gataccggaa acagcttcca gggcgccgtg atcacaccat 1401421 actatgattc acttctcgtt aagctttcaa cttgggcttt aacgtttgaa caggcagctg 1401481 ccaaaatggt gcgaaacctt caggagttta gaatcagagg cataaaaacg aacattccgt 1401541 tccttgagaa cgttgcaaag catgagaagt tcctgacagg gcaatatgat acatctttca 1401601 ttgatacaac gcctgaatta tttaatttcc ctaaacaaaa agaccgcgga acgaaaatgc 1401661 tcacttacat cggcaatgtg acagtgaacg gcttccctgg aatcgggaaa aaagaaaaac 1401721 cggcgtttga caaaccgtta ggcgtaaagg tagacgttga tcagcagcct gccagaggaa 1401781 caaagcaaat tctcgatgaa aaaggtgcag aagggcttgc aaattgggtt aaggagcaga 1401841 aatctgtcct tttaactgat acgacattca gggatgccca ccaatcgtta ttggcaacta 1401901 gaatcagatc gcatgatttg aaaaaaatcg caaatccgac ggctgcgtta tggcctgaac 1401961 tattcagtat ggaaatgtgg ggaggcgcga ccttcgatgt agcctaccga ttcctgaaag 1402021 aagatccgtg gaaacgtttg gaagatcttc gcaaagaagt gccgaatacc ttattccaga 1402081 tgttgcttcg ctcatcaaat gcggtcggct atacgaatta tccggacaat gtgattaaag 1402141 aatttgtgaa gcaatcagct caatccggta ttgatgtgtt tcgtattttc gacagcttaa 1402201 actgggtaaa agggatgacg ttagccattg atgctgttag ggataccggc aaagtggcag 1402261 aagctgcgat ttgttatacg ggagatatcc ttgacaagaa ccggacgaag tacgaccttg 1402321 catattatac atcgatggcg aaggagcttg aggcggccgg agcccatatt ctcgggatta 1402381 aagatatggc agggctgtta aaaccgcagg ctgcatatga gctcgtttct gcgttgaaag 1402441 aaacgatcga cattccggtt caccttcata cgcatgatac gagcggaaac ggtatttata 1402501 tgtatgcgaa agctgttgaa gccggcgttg atatcataga cgtggcggtc agctcaatgg 1402561 cgggattaac gtcacagcct agcgcgagcg gattttatca tgcgatggaa ggcaacgacc 1402621 gccgtccgga aatgaatgtc caaggcgttg aattgctgtc ccaatattgg gagtcggtgc 1402681 gtaaatatta tagtgaattt gaaagcggaa tgaagtctcc gcatactgaa atttatgaac 1402741 acgaaatgcc agggggccaa tacagcaacc tgcagcagca agccaaggga gtaggccttg 1402801 gcgaccgctg gaacgaagtc aaggaaatgt acagacgcgt gaacgatatg ttcggtgaca 1402861 tcgtcaaggt aacgccttcc tcaaaagtag tcggagatat ggcactctac atggtgcaaa 1402921 acaatctgac tgaaaaagac gtttacgaaa aaggtgaatc tttagatttc cctgattctg 1402981 tcgtggagct ttttaaagga aatatcggcc agcctcatgg cggattccca gaaaaactgc 1403041 aaaagctgat cttaaaaggg caggagccga ttacagtcag accgggcgaa ctgcttgagc 1403101 cggtgtcatt tgaagcgatc aaacaggaat ttaaagagca gcataacttg gaaatttcag 1403161 atcaggatgc tgtggcatat gccctttatc ctaaagtctt cactgattat gtgaaaacga 1403221 cagaaagcta tggagacatc tcggtattag atacaccgac attcttctac ggtatgacat 1403281 taggtgaaga gatagaagtt gaaattgagc gcggcaaaac gctgatcgtt aagctgattt 1403341 caatcggtga gcctcagcct gatgccaccc gcgtcgttta tttcgaactc aacgggcagc 1403401 cgcgtgaagt agtcattaaa gatgaaagca ttaagtcttc cgttcaggaa aggctgaaag 1403461 cagaccggac aaatccaagc cacatcgcag cttccatgcc tggaacagtt attaaggtat 1403521 tggctgaagc aggcacaaaa gtcaataaag gtgatcattt gatgattaat gaagcgatga 1403581 aaatggaaac aacggttcag gcgcctttct caggaacaat caagcaggtt catgtgaaaa 1403641 atggtgagcc gatccaaacg ggagatctgc tccttgaaat tgaaaaagca taaaaaacaa 1403701 agagtgtata tcaatgatat acactcttgt tttttatata gaaaatgtgg agtgaaacag 1403761 atggttagaa gagatataag gggacttcag agattataga gtactgtcac aagcccaaaa 1403821 taaaaagagg cttatacagc caatatttta gatgctttgt agtatgccgt gcatatttct 1403881 ttaagcacta tctgatttaa aaggctttaa tacttatgtt cgcgagctat agatccatat 1403941 gaaatttcta taatcacgat gagaaagggg acagaccgaa gtgagccgct cactgatcat 1404001 caagttcggc gaaggctggc gattgaaacg cataaagcgc caaaaaacaa gacataaaaa 1404061 agaccaaagc cgcctaaggc tttggtcttg agtccttatg attgcctgga ttcataacgg 1404121 aaacgagcaa tcaataataa gaagtagcat agaacgccaa acagacaggc aataaagaac 1404181 gagtgggcaa gtgcaaagcc cagagccagt tcagagtata cgatcataat accggacagt 1404241 gcctgtaatg taatgaaaat aagacatgag atccatcccc aaaagatctg tttttgatct 1404301 ttataggaag taatagcatg aacagcggca acaataatcc atacaaataa aagtaaggct 1404361 gctgctctgt ggcccatttg cacccattca tggaattggg tcggaagtcc attgttcagc 1404421 gggctgcaca gcggcacatt aggacatgcc agacttgatt cagtgtgtct tacatatgcg 1404481 cctgtataca caacgatata ggaatatatt aaaattccta tcatgtgaaa ttgcatcttt 1404541 ttgccgattt gaagcggctt aaccagtgtt ctgactgatt tatcagcttc aaatatgagc 1404601 aatgttaaaa taagcactga agcaaaagaa attaatgaga tgccgaagtg aagcgccata 1404661 atcagcgcgt tcgaaccgaa tacgacagcc aatgcgccaa gcaatgcctg aagaaataaa 1404721 aagataattg acatgatcgc gagaaacgtt gtttcacgaa aaatcggcgt gatttttctc 1404781 catgaccaaa acgcaaggct tagcacaagg ataatagaga ttccgcttgc gaatcggtgg 1404841 ctccattcaa taattgaagc cggattcagt tcagggaaaa aacggccgtg acacagcggc 1404901 cactgtctgc cgcatccttg gccggaacct gtttttgtaa cgagggcacc cccgattaaa 1404961 acaattagca tgacaaatgt cgtcagaaca ccgagagctt ttaatgcttt attcatacaa 1405021 tattcacctt cttaacatac tgctgcaatt ttatatacgt tccaagtgta agcgaatatg 1405081 tgttttgtgg caattcccag agccttttgt tcacaaaaat ataatagaat gacggcttct 1405141 ggaaaatgta cacttgatta ttcatgccgg gtctgataga aataaggtaa acgcaatgcc 1405201 gatttggaga ttgccttcat ctttggtaaa attcataaaa agttcacaaa taaattcctg 1405261 tttgtcgttt aatatttaat aggatgtttt tttacaagat gttatcttgt atgatagagt 1405321 tgcaggttat tttattctcc tgcgttaggt ttgtaaggga ggtttacgtt atggctaact 1405381 ccagaatctt aaatgataca gctatagacg gacaaattga agaaacaacg gcatggaaag 1405441 attttctgtc ccttattaaa atagggatcg tcaattctaa cctcatcacg actttcactg 1405501 gaatgtggct tgcactgcat atatccggtt taagtttttt aggcaatata aacaccgttc 1405561 ttcttacgtt aatcgggtct tcactgatta ttgcgggctc ctgcgcgatc aataactggt 1405621 atgaccggga cattgaccat cttatggagc gtacgaaagt aagaccgacg gttacgggta 1405681 aaattcagcc gagtcaggcg ttatggtctg gaattttgct ggttgcttta ggattgatca 1405741 tgctgctgat gacaactgtc atggctgctg ttatcggttt tatcggagtc tttacgtatg 1405801 ttgtattgta cacaatgtgg acgaaacgcc gctatacgat taacacagta gtaggaagcg 1405861 tttccggtgc agtgccgccg cttattggat ggacggcagt ggaagggaat atcggtgtcg 1405921 tagcatgggt gttattcatg attttattta tttggcagat tcctcacttc ttagcattgg 1405981 ctattaagaa aactgaggat tacagagctg caaatattcc gatgcttcct gtcgtatacg 1406041 gatttgaagt gacaaaaaga caaattattg tgtgggttgc gtgcctgatg ccgcttccgt 1406101 ttttccttgg tagcctgggt cttccgattg tcattctcgg cttgctgtta aatatcggct 1406161 ggctgattct tggcttaatg ggattccgct ccaagaatat catgaagtgg gcaacgcaga 1406221 tgttcgttta ctcgcttaac tacatgacaa tctatttcgt tgccatggtt gtcttgacgc 1406281 ttttctaaaa aatagatatg atgcttgttt tatcgcttca aaataaacga tgacaactag 1406341 taaatgccgc cttgacctct tgtttaatca ggcggcttta cttttataca tagatggcat 1406401 tttgagtaaa aaaactcata atttaagaga agaggaaatg taagtgcttt attggtgata 1406461 ggttggatgg cgatagattt cgatccgctt tccgcctttg tattgaccag aaaaggggtt 1406521 gggtgaaatg gtaaagcatt ggcgtcttat tttattatta gccttagtgc cgcttctatt 1406581 aagcggatgt ggaaaacctt ttttatccac gctcaagcct gctggcgagg tggctgataa 1406641 acagtatgac ctgacagtgc tcagcacatt gattatggtg gttgttgttg cagtagtatc 1406701 tgttatcttc ttttatgtga ttgtgagatt cagaagatca cgggtcggtg agaacacgat 1406761 accgaaacag gtagagggga ataaattttt agaaatcaca tggaccgtga tcccgatttt 1406821 gctgctcatt attcttgtga ttcctgttgt attatatacg ctggagctag cggacacatc 1406881 accaatggat aaaaaaggcc gcaaagctga ggatgctctt gtagtcaatg ttagggcaaa 1406941 tttatactgg tgggagtttg agtaccctga ttacggcatt atcacaagcc aggagctgat 1407001 tgtaccgaca gatcagcgtg tatattttaa tttaaaagcc tctgatgtaa aacattcctt 1407061 ctggattcct tcagttggag gaaaacttga tacgaatacg gataatgaaa ataagttctt 1407121 cctgacattt gattcaaaac gaagcaaaga ggcaggagat atgttttttg ggaagtgtgc 1407181 agagctttgc ggcccttcac atgcgctgat ggattttaag gtgaagacga tgtctgcaaa 1407241 agaatttcag ggctggacaa aagaaatgaa gaactataag tctacagcag agagcgattt 1407301 ggctaagcag ggtgaagaac tgtttaaaga gaaaaactgc ctgagctgcc atgcggtaga 1407361 gccgaatgat aagcgtgcag aagccgctag aacggcacct aacttggcga ccttcggtga 1407421 aaggacaaaa gtggcagggg tgaaagaggc caacaaagaa aatgtgaagg cttggctgaa 1407481 ggaccctgac agcataaagc cggggaacaa aatgacaggc acatatccaa agctctcaga 1407541 cagcgaaaca aatgcgcttt atgaatactt aaaaggctta aaagcggaaa gcaagtaggg 1407601 aagaaaggga gatattgggg gaggtcacat atgttgaatg cgcttacaga aaagcggacg 1407661 cgcggatcta tgctttggga ttatttgacg acggtggacc ataaaaaaat cgcaattctt 1407721 tatttagtgg cagggggatt cttctttctt gtcgggggaa ttgaagcgat gtttatcaga 1407781 attcagcttg caaagccgga aaatgcgttt ctcagtgctc aagcgtacaa tgaagtaatg 1407841 actatgcacg gaacgacgat gatctttctg gctgcgatgc cgctcttatt tgccttgatg 1407901 aatgcggttg tgcctttgca gatcggggct cgggacgttt cgtttccatt tttaaacgcg 1407961 cttggttttt ggctcttctt tttcgggggc attttcttaa atctaagctg gtttttgggc 1408021 ggagcgccag atgcgggctg gacatcatat gcctcacttt cgcttcattc taaagggcac 1408081 ggcatagact ttttcgtcct cggactccaa atatcggggc tcgggacgct gatagccggg 1408141 attaactttt tggccacgat tatcaacatg agggctccgg gcatgacgta tatgaggctg 1408201 cctttgttta catggacgac atttgtggcc tcggcattga ttttgttcgc gtttccgccg 1408261 cttacggttg gattggctct catgatgctg gatcggctgt tcggaaccaa tttctttaat 1408321 ccggagcttg gcggaaatac ggtcatttgg gaacatttat tttggatctt cggccacccg 1408381 gaggtttata tcctaatttt gcctgcattc ggtatttttt ctgaggtcat ccctgtgttc 1408441 gccagaaagc gtttgtttgg ctattcttca atggtttttg caatcgtgct cattggcttt 1408501 ctgggcttta tggtttgggt gcaccacatg ttcacgactg gtctcggccc gattgcaaat 1408561 gcgatttttg cggttgcaac aatggctatc gcgattccga ccgggattaa gatttttaac 1408621 tggctgttga cgatttgggg aggaaatgtg aagtatacaa ccgctatgct gtatgctgtc 1408681 tcatttattc catcctttgt gctcggcggt gtgacgggag tcatgctggc agctgctgcg 1408741 gctgattatc agtttcatga tacgtatttt gtggttgcgc acttccacta cgtcattatt 1408801 ggcggcgttg tattcggcct tttagccggt gttcatttct ggtggccgaa aatgttcggt 1408861 aaaattctgc atgaaacgat ggggaaaatt tcatttgtat tgttttttat cggctttcac 1408921 ctcacgtttt tcattcagca ttttgtcggc ttaatgggga tgccgcgccg ggtttatacg 1408981 tttttgccag gacagggtct ggaaaccggc aacttgatca gtacaatcgg ggcgtttttt 1409041 atggcggcag ctgttattct tctgctggtc aatgtcatat ggacatcggt aaaaggtgaa 1409101 tatgtaggtg ctgatccatg gcatgacgga cgtacgctgg aatggaccgt ttcttcaccg 1409161 ccgccggagt ataactttaa acagcttcct tttgtcagag gacttgatcc gctttggatc 1409221 gagaagcagg cagggcacaa atcaatgacg ccggcggaac cggttgatga tattcatatg 1409281 ccaaacggct caatcctgcc gctcatcatt tccttcggcc tttttgtcgc agcgttcggg 1409341 ctgctgtaca gaagtgatta cgcttggggc ctgccggtga tctttatcgg gctcggcatc 1409401 acatttatta cgatgctgct tcgttcagta attgatgatc acggctatca tattcataaa 1409461 gaggaactgc cgaacgatga taaaggggtg aaggcataat gcaagttcaa gaaaaattca 1409521 ccgcagaaac ctttccagct tctcctgaaa aagtaaccct ggaagggaaa aataaatttt 1409581 taggcttttg gctttttctt ggcggagaga ctgttctgtt tgcgtctctc ttcgccacgt 1409641 ttcttgcgct tcggaattca aatgccggtg atccgcctac gacggaaatg ttcgatgtga 1409701 cacttgtatt cattgccaca atgcttctat taacgagcag tttaacgagt gtgtacgcga 1409761 tgtaccacat gaagaacttt tccttcggca agatgcagct ttggctggga attacgattt 1409821 tattgggggc gggcttttta ggactggaaa tctatgagtt caagcattac acccatgaat 1409881 ttggctttac catcacaagc tctgcccttg gttctgcgtt ttacacgctt gtcggtacac 1409941 acggcgccca cgtggcattt gggcttatgt ggatcagcac gcttatgatc cgcaatgcca 1410001 agagagggct gaatctgtat acggcgccta agttttacgt tgccagcctt tattggcact 1410061 ttattgatgt cgtgtgggtc ttcatcttta ccgttgtata tttaatgggg atggtgggat 1410121 aaacatggtc gataaaaaaa gcagagggca tatcaatagc gaccttgaat ttaagaaaaa 1410181 aaagcatgcc cgggagatga aatatcaagt cctgtctttt ggtttaatga tcggtcttac 1410241 gattgttgca tttctgactg tggccacgga cggtgtcggc agctggttta cgattccttt 1410301 cattattttg ctagctgcaa ttcaagtcat ttttcagctg tattatttca tgcatatgaa 1410361 tcagaaaggg catgaggcgc cggcactgtt tttgtattca ggggtgtttg tcgcgtttat 1410421 cactgtgctt gcgtttgtga caattatatg gtggtaattt gaacagccgc cggaggtgaa 1410481 gaaatgaatc agttggagat atttgggttt cgcgcgatgt ggagccctta tcttttttgt 1410541 atcctgttag gcattacggc gctttatctc tatttttaca ggcgaatgtc ttcaaagccg 1410601 aatcgaataa ctggtaaaga gatggtgtgc tttctgtcgg cgatgctgtt tttatatgca 1410661 gccgagggaa gcccggttga tctgctcgga catattatgt tcagtgcgca tatggtgcag 1410721 atggccgtcc tgtatttggt tgtcccgccg ctgttaatcg cggggattcc tgcatggctc 1410781 tgggaaaaaa tcattttcag gccttcaatc aaaccggttt tttccttttt tacgacgcct 1410841 ttaattgctt tgcttttgtt taacggcatt ttttctttat atcatgtacc gcttatattt 1410901 gatactgtca aaacagatcc gttttaccat acattaatca cttggcttat ctttgtgctt 1410961 gcgttcttca tgtggtggcc gcttgttcat aaggttgagc gtctacggca gctcagcggc 1411021 ttgatgaagc tgggttatat tatggcggac ggtatgctgc tcacacctgc ttgcgccttg 1411081 atcatgttca gcggtgcacc gttatacgcc acctatacag atccggcttt atgggctgag 1411141 gcaatgaggc tttgcgtgcc agcggatatg atggggcagg tcccattaac agggccagag 1411201 atgttgaata cactgccttt gttagaggat cagcagctcg gagcagtcat gatgaaaatc 1411261 attcaggaaa ttgtgtacgg tacttttttg gccgttattt ttttccaatg ggtgaagaaa 1411321 gaaagggaaa aggacgggca ggaggagccg ccgtatattc agcagacgat atcataaaag 1411381 gtacagcgaa atatgctgta ccttttcgtt acatttgaac tgtttttaac atgttggcta 1411441 tgtcctgaat cagtgccttg ctttttgtca caacctgtac gggaaactct tccgtttctc 1411501 catattctac tccatgaggg tagtaatgct ttcctaggag aggggacatt aattgaatca 1411561 cggcgcgccc gcttccgaca tcgccttctg ccgcaatacc ttgtatccgc aggtaaaacg 1411621 taccctcaat cgtcgaaaac ttcttgtcat aggtgactct ctcgtaatcc cattgacccg 1411681 ctctgataag acctttgctt tccattaagt cgtctagcca gctgagctca gccttaaccc 1411741 cttcaagtcc gctttcagta aacttcaaca ctgacccctc cttataaaaa ttacctttcc 1411801 tgacaatcat agtatgaaag cgttaaactt tcaatgaatc ttcttctttt gaaagtatgc 1411861 aaaaattaaa ttttgacgac aatagcacta gactaaagga ggttaaacgg atgacaaaaa 1411921 taaaagatct gatgacagcc gacttgcaat attgcacggt attagataat gtatatgaag 1411981 ctgcagtaaa gatgaaggac gcaaatgtag gagcgatacc ggtagttgat gaggacgggg 1412041 aaacattggt cggcatcgta accgaccgcg atctcgtatt aagaggaatc gccatcaaaa 1412101 aaccgaactc gcaaaaaatc actgacgcga tgactgaaaa acctgtcagt gtggaggaag 1412161 atgcttcagt cgatgaggtt cttcatttga tggcatcgca tcagctcaga aggataccag 1412221 ttacaaaaaa taaaaaactg actggaattg tcacgcttgg tgatctttct ttatctgagc 1412281 aaacgaatga acgtgccggc agcgccttat cggatatttc cgaaggggat aatagagaag 1412341 aaggcttttt tcattaacac ataaatcttt gacatgttaa ataggctgta ttgtaatggg 1412401 atgtaaacaa gagattgtga atcgccacgg gggtgataga ttgaaaaata tattgagagc 1412461 aatggttatc cttttgatta tctgcggaac ctatgttctg tttattcaat atggatctgt 1412521 tcctgaaaag aaatcaaatg acagcgagcc tcaggtgtcg aatgaggaag cgcaaagcgg 1412581 caaacgaata catatgccga cttcagggtt attgtccttc atgggcaagc acgccgatga 1412641 agtaacgaaa aagcttgggg aacctgaacg tattgaccct tcggcttatg attacgattg 1412701 gtgggtatac aatcaaggta aggatcaata tatccaaatc ggggtattaa acaataaagt 1412761 ggtcacatta ttcgcgtcgg gtaatgatat taacgccaag cctttcaaaa ttggagaatc 1412821 aactggcgaa gtattcaaga ccacccaggt ggcaccattt gtgaatgtag agtataaagg 1412881 aaattcctat cggtttgaat tttctgaaga agatatcaat acaagaccga ctgtaaaggt 1412941 aggaaagatg tatgtccagc tgtatatgga caaatttgag gggaagctat ccagcatcag 1413001 ggcgtttgat gcgcagacct ttgtaaagca aagaccttat gaggtagtgt accgcgggga 1413061 attaattaaa ccgaaagccg tttcagatga gaaatggaaa aagatccaaa caacgagcga 1413121 aaagcaaatc cttgatttga cgaatgtcat acgcgttaaa catggacttg cgaagcttga 1413181 gtgggatcag ccaacggcgg aagtggcatt tgggcatagt gaggatatga aggaaaataa 1413241 ttatttctcc catgtctcta aaaaatacgg ctcgctgaaa gaccgcttag aagaagggca 1413301 tgttgatttt cagcaagcgg gagaaaatat cgcatacaat tatgtggacg gtccggctgc 1413361 tgtagaaggc tggctgaata gcgaaggcca tcgaaaagcg cttctgaatt cagattatac 1413421 gcatcttggt gtcggagtag accggaaata ttacacccaa aactttatta agcgatggta 1413481 atgaaagccg cggacgaatg gttcccggct ttttctattt ccatacaagc tggtctgaat 1413541 gaatgtgctg atagcttaca gataaggccg tttcccatcc cttcagtcag gctttttcac 1413601 cagtgtatag ggatatcgct aaaaattcat ttgggaatga atataggcga acacaatgcc 1413661 cgacaaaacg atacattgta gtaggtaacg attttcggag ggggtgagga ttgtggcgaa 1413721 tcaacatgcc aatcattcaa tcaatgactt taaacaattc gtcaaaaagc atcccaagct 1413781 gataaaagaa gtgcgcaaag aacaaagaag ctggcaggac gtatatgaaa attgggtcct 1413841 cttcggggag agcgacccga tttgggatcc atatcgggaa ccggaagaag cttctgaagc 1413901 tgtgcctgaa acaccgcaaa aaaatgattt tgtctcgaaa atggtgacag cggtgaaaaa 1413961 gatggatgtc aatcaaatga acgaacaaat caataaaatg agccagtcga tctcatcgtt 1414021 gcaaagcctt cttaatacat tttccggaag cggacagaag cattctcagc caggctctgg 1414081 acagcatcct ttttcttttc gaaaggatta aaaaagggga gctcatatgc gcaaagaggt 1414141 tcaggaatat attttagcaa acgaagaacg gaaacgattc atcagagaac agccgatatg 1414201 gtaccgcagg ctttcaagaa aaccggatga tctgtcctcc tttcagcttg aaatgatgaa 1414261 tttttatgaa aaaaccattc cgcatcgggt gaatcagttt acgaacggga ttcaaatggc 1414321 gcaaatgatg atgcaaatgt ttcaagcgat gcggacaaaa gattaaaagg ccccgaagaa 1414381 gggtcttttt tcatgcggtc ataaggtttt gttggcggct gcggttaagc attttccaat 1414441 tggctggttt catggtaaac taacaactgg aggtgcatgt tatgtatgcg acgatggaat 1414501 ccgtgcggct tcaaagtgaa gctcagcagc ttgccgagat gattctgcag tcggagacgg 1414561 ctgagaacta ccgcaattgt tacaagcgtc tccaggaaga tgaagaggca ggtcggatta 1414621 ttcgttcttt tatcaaaata aaagagcagt atgaggatgt acagcgtttt ggcaaatatc 1414681 atcctgacta tagagaaata tcccggaaaa tgagggagat caaacgtgag ctggacctga 1414741 acgataaggt ggctgacttc aagagagctg aaaatgagct ccagtccatt cttgatgagg 1414801 tcagcgttga gattgggaca gctgtttcgg agcatgtgaa agttccgact gggaaccctt 1414861 attttgacgg tttgtcttca tgcggaggcg gctgcggttc aggcggaagc tgcggatgta 1414921 aagtgtcctg acgagactgg ccgtctcgtc ttttacatat aagagaaaac aggcaggtga 1414981 ttgtattgga gaataggcgc cagggcatgg ttgtgtatct gcactcccta aagcagagca 1415041 aaatgctgag gaagttcggg aatgtgcact atgtatcaaa acgattaaaa tatgtcgtac 1415101 tgtactgtga tatggaccaa attgaaaaaa caatggacaa gattgcgtct tactcatttg 1415161 tgaaaaaagt ggagccttct tataaaccgt ttttaaaatt ggaattcgag tcaaagcttg 1415221 ataaggcaaa agaatacgat tataaaatcg gcatatagct ataaaaaaat ccccgcaggc 1415281 atctgcgggg tccttctatt ccttaatatg ttaaggagaa ggcaaaggga gaggagaaac 1415341 cggaggaaga acttatgggg aaacgtaagt cttctccgcg gttggcaaca acatcctcta 1415401 gatgctgttg cttatagtat ggacaaggat catgctgcct atacacctgt ttatcaagat 1415461 tagcgttcat tgtttggaag aatgctttat gttaagatag gattgatttt tttctatgta 1415521 catagcggcg tccggccgaa taaagaaaca aaatagcttt tagaaaaagt ggtgtggaac 1415581 atgagagtaa tttctggatc aaaaaaaggc cgttcactaa aggctgtagc cggaacatca 1415641 acaagaccga caaccgacaa agtgaaggaa tccattttca atatgatcgg cccttatttt 1415701 gacgggggca ggggacttga cttattcgca gggagcggag gtcttggaat cgaagcgctt 1415761 tcacgcgggt ttgagcattg tatattcgtt gaccgtgatt ttaaagcgat tcaaacggta 1415821 aaatctaatt tgaaaacgct ggagcttaca aaacatgcac aggtataccg caatgatgcg 1415881 gaacgtgctt tgcacgctgc tgctaaaaga gaaaccggct ttcgcggaat ttttctcgat 1415941 ccgccgtata aggaacaaaa gctgaaagca cttttaactt tgattgacga atatcaaatg 1416001 ctggaagaag acggctttat cgtcgctgag catgacagag aggtcgagct tcccgaaacc 1416061 gtaggagatc ttgtgatgac aagaaaagaa acctatgggt taacaggtgt agcgatttat 1416121 aaaaagaggg ggtagtgagg tggcgagtat agctgtctgt cccggcagtt ttgatcctgt 1416181 gacctacggg catctggaca tcatcaaacg cggggcgcat atttttgaac aagtgtatgt 1416241 atgtgtgctg aataattctt caaaaaagcc tttgttcagt gtggaagaac ggtgtgagct 1416301 tctgagagaa gtcacaaaag acattccgaa cataacagtt gaaacatcgc aaggcctgtt 1416361 aattgattat gcaaaaagaa aaaatgcgaa agcgatttta agaggcttga gagctgtatc 1416421 tgattttgaa tacgagatgc aggggacatc agtaaaccgg gtgcttgatg aatctattga 1416481 gacgtttttt atgatgacaa acaatcaata ttcgtttcta agttcaagca tcgtaaaaga 1416541 agtggcaaga tacaacggct cggtatcaga gtttgtaccg ccggaagtag agttggcgct 1416601 tcagcaaaaa ttcagacaag gatgagggtt ttgactcatc ctttttttgt tccgtttgtc 1416661 agtctgtaag aaaaaatgat aatgtacgta aacagcgcgc atagtgtgac agcaggtccg 1416721 atctgcacaa gcagattcca gccgtttata aaggcagttg acatgtcact gctgttaaga 1416781 gatttaaata catactgata cggatcatgc catgctgtgt aaagaggttt ccataaaagc 1416841 atgacgaaga cagcggcata aacgccctgc agcaaacgtg cgataaagaa tggtttaaat 1416901 ctaatgtcgg tttccgataa aatacctgcc acctgagctt gtacggaaaa gccgctaaac 1416961 ccaagaataa agctgacgat aatggctttt tgcagaagag aaacatctgt ctcgctgaca 1417021 agcttgctgc ctaatgtaat ttcaaacatc cctgataaaa gcggaatgtc caattgagtc 1417081 ggaagctgaa acaaagtcag tgctcctttt gtgaaaacag acaaaacatc agtcagctgg 1417141 accactgaca acagccgatt gaagacagaa aataaaataa taaagccgcc taccataaga 1417201 agcgtttgaa cagaagacgt cacggcgtcg cctaaaattt tacctaaggg ccgtttttct 1417261 gcaagtctgg cggtatgaag agcgtgtaaa gcatctttga ctgaagggaa aggtatcgtt 1417321 ttctttcttc tgagatgctg ctcttccttg cggccatagg agcgcattgt taaaccgacg 1417381 gcaagattcc ccaaatagtg tgcagaagct aataaaatgc ctagtgatgc gttttgaaag 1417441 aaaccgacgg caacagcgcc gaaaataaag agcgggtttg aagaattggt aaacgacgcg 1417501 agccgttctg cctctactct tgaaatctga ttttcctgcc gcagacgggc agtgagtttt 1417561 gcgcccgctg ggtttcctga tgccattccc atagcaagaa cgaagccgcc gacacccggc 1417621 acgcgaaaga tcggccgcat aaaaggctca agcaaaacac cgacaaaccg cacaatgcca 1417681 aagccgatta agagttcgga cagaataaaa aatggcagca atgacggaaa cacaacctcc 1417741 caccacatag acagcccggt tttagaggct tcgaatgagg cctgtggatg tgagatgaca 1417801 gtcgctgtta aaaaaagaaa aaacgaggca atcaaaagtg tattaatctt cgacaagttc 1417861 attcttacct ccccgatgct aaaaatgccc aatgacatgt atatcatgat aaaataatgt 1417921 atgatgtaaa acggccaagc agtacctgtc ctcttgattc tttgtactaa tatacgagca 1417981 taggggttca gtttagacca tagaattcgg tatacaggga attcaggcag gaggttaacg 1418041 ctttggccaa acctaaaatc gggttagcgt taggatcggg aggggccaga gggcttgctc 1418101 atctcggtgt gctttccagt ttacataagc accaaattga agtggatatg attgcaggaa 1418161 gcagcatggg cgctttggtg ggcagttttt acgccgccgg acatgacgtg gcaacgatga 1418221 aaaaagtagc caaagccttt aaacgaaggc tttatgctga ttatacggtg ccgaaactcg 1418281 gttttttaaa aggtgaccgc gtcagacagc ttgtgcatgc ttatacattc ggaaaaccga 1418341 ttgaagagct ccaaatcccg ctgggcattg ttgcgtgtga tctacagacg ggagaaaaga 1418401 ttgtgttccg aaaaggatca gtgtcagatg cagtgagggc cagcatcagc atcccgggta 1418461 tctttattcc gcagcggctg gacggacgcc ttcttgtaga cggcgcggtc gtcgatcgaa 1418521 ttccggtttc tgttgtgaaa gacatgggag ctgatattat catcgcttcg gatgtttcca 1418581 gggttcgaaa aactgaaaca gcagtgcata tttttgatgt gattatgcaa agtatggata 1418641 tactgcaaaa tgaattagtg cggcatcaaa caattgccgc agatatcatg attcgccctt 1418701 cccttgaaac atacagctca agctcgtttg ccaatattga agaaatgata tcggcaggcg 1418761 aagaggcgac aaaccgaatg atcagcaaga taagaaaaga aatagagaat tgggagggct 1418821 cataatttgc tacgtaaaaa acattttagc tggatgctcg tcatcctcat actgatcgcc 1418881 gttttatcat ttataaaact tccatactat attacaaaac cgggagaagc gacagagctt 1418941 gcttcattga taaaagtgga gggaggctac ccggaaaaag gaagtctgtc cttaatgact 1419001 gttaaagtgg gaccggctaa tccatttaca tatgtgtggg caaagatgca cccttattat 1419061 gaaattgttc ctgatgagag cattaaggag gaaggcgaat cagataagga gtatatgaaa 1419121 agacagctcc aaatgatgaa aagctcgcaa gaaaatgcgg ttatagccgc ctatcaaaag 1419181 gcaggaaaaa aagtcagcta ttcctttaac ggcatatacg caagctcagt tgtagaaaac 1419241 atgccggcaa aagggaaaat agaagtcggt gataaaatca tcagcgcaga cggcaaaaac 1419301 tatcagtctg ctgaaaagct gattgattat atcagcagca aaaaagcggg agataaagtc 1419361 acgttaaaga tcgaaagaga agaaaaagaa aagcgtgtca cccttacgtt aaaacaattt 1419421 cctgatgagc cggatcgggc aggaatcgga gtttcgcttt atacagacag aaacgtgaag 1419481 gtagagcctg atattgattt tgaaatcgaa aatattggcg gcccgtcagc agggttaatg 1419541 atgtcccttg aaatctataa tcagctgaca aaaccagacg aaacaaaagg ctacgatatt 1419601 gcgggaacag gtacgattga tgttgacgga aaagtaggcc cgatcggcgg cattgatcaa 1419661 aaagtcgtcg ccgcagacaa agccggaaaa gacattttct tcgcgccaaa tcaaaacggc 1419721 gccagcaatt ccgattataa gaacgcagta aaaacagcaa aagatattga ttcaaatatg 1419781 aagattgtgc ctgttgatac catgcaggat gcgattgatt atttgaataa gctgaaagcg 1419841 aaaagcacct gattctcagg tgctttttct atacatttaa aaagtgttgt tcatcttcgt 1419901 catatcgaat cggtgcatgt ccgtattcct gtaggtcaaa ctcagttctc agcggctctt 1419961 ctatcggcag gctgtaaatc ctgcttgctt ttacgtccag atcgagagct ggatgggaga 1420021 aagaggacag tttgctgaca agcggaacag acagtgcttt tttcttttcg gataaataag 1420081 cctgtccttt tttcgtcatg ccgagaagcc tgatatacgg cgccttatcg ttgtcaagca 1420141 gcttttgcat atcctgtttt tttgttctgg ttaaaatgtg tgtattcatc cgctggagcc 1420201 ttgtccacgt atagcgtttt gttttcagca gttccataaa ttcctgatag gagctggatt 1420261 ttctgatcga acgaataatt ctgtgctcta aaccttcctc cacctcgtat acttgctgta 1420321 attcccgtgc cgttacagtt gaaaggctgt attttaagta agaaaagtag ctttcaggtg 1420381 tatgccacaa tccgaaagat ttgcggtaag ctgctaattc acgtgcagat gcagcaggga 1420441 gaaaacgaag gcaggcttcg agattctggc caatcatcgc ttttctaatg cttgtggcac 1420501 ttgctatatg gttttcgcct tcagggagat cggcatcatg atagtccgaa gagattcgtg 1420561 ccgtagtata aggtttcata ggatatcccc cggttagaat cgaggtcaca tactggtatc 1420621 ccaaaatgtt atttggtttt gacaagtcaa gtgcactttc agtatgcaaa atggagctga 1420681 aggcgatagc cgccgctgct gggtaactgg cccccttttt aagttcttct ttaattcggt 1420741 cattcaatat atgtttatgc tcatcaataa gctgtgctgt ttctaaaaaa ggcttgatat 1420801 ccccattttc actcccgaaa aacagcgcct cacattcaag ttcgttcagg atggaaacac 1420861 tgccgcgtgc aaaaatgtct gctttttgca cggcataaag ataaggcagc tcaatgacaa 1420921 gatcaactcc gctttgcagc gccatttttg ttcgggccca ttttgataca acagcgggtt 1420981 ccccgcgctg taaaaaatgt ccgctcatga ccgcgacagc cgtgtcacat ccggtttgca 1421041 gctttgctgt ttgggcatga taaaggtgac cgttatgaaa gggattatat tcaaccacca 1421101 atccgacagc tttcatattt tttccgcctt tcttgctatg tttaaaaacg tatggtacat 1421161 ttgcaaatga aaactcttac gccttatttt tgttttaagt gtatgcatag catattccgc 1421221 tgtcaacgat acttcaatgg cagcattatg ctgtaaagaa aaaatattga caaaaacaat 1421281 cttaaaagct ataatcatgt ttgttgcttt cctgaggtga tacaaatgaa atggacgatt 1421341 tatcagctgc atcaaatgcc aaaacaaagt tttgagtttg atgaaacagt tgagttaaat 1421401 gagctgacaa agctgaattc tgacattcgc cgcatttctc ccgttcgggt gaagggcaga 1421461 gcggatatca aatccaaaca ggtttcgttt gattttacaa tttcaggcga aatgcttttg 1421521 ccatgctcaa gaacactcgt tgatgttccg tatccatttg aaatttcaac aaaagaactg 1421581 tttatatttc atcacacgga tgatatagaa gatgatgacg ttcacattgt tgaggacgat 1421641 actatcgaca taactccgat cgtgaaagaa gaaattcttt tagaaatccc tatgcaaatc 1421701 ttttgtgaat ctgaacaaga aaaaggagct gctcctcaag aaggaaagga ttggcaagtc 1421761 atttcggaag aagacaagaa gaatcaagtt gatccgagac ttgcagccct tgaaaagctc 1421821 ttaaaacaag atgatgaatc ttaactcttt aaggaggtgg gaataatggc tgtacctttt 1421881 agaagaactt ctaaaatgaa gaaaagattg cgccgtacac atttcaaact taatgtacct 1421941 ggtatgacag aatgtccgtc atgcggagag atgaagttgt ctcaccgtgt atgcaaagca 1422001 tgcggatcat acaacggcaa agacataaat gtaaaaagta actaatgaga aaagcgcagg 1422061 gtgaaagccc tgcgcttttt ctttttctct tcctgtcagc ttgcggaaaa tttgtgagtg 1422121 caaatagtct atctaatcta ttaccggcat atgtatgaga taaataagct gacatggagg 1422181 gagattgaat ttgaccatta caagacaaga tgcttggact caggatgagg atttgctgct 1422241 ggcagaagtg gtgcttcgtc atattcgaga gggaggaaca cagctttcag cctttgagga 1422301 ggttggaagg gcgctgacca gaaccgcggc agcctgtggt ttcaggtgga actcgtatgt 1422361 gagaaaacaa taccagtcag gtatagagct tgcaaaaaag caaaggaaag aactgagaaa 1422421 gcaaatcggc gttcattcgg tcaatatgcc gaattccatg aagcagactg cctcggcatc 1422481 gtcagaagga aaacgagatt tgtccattca ggatgtcatt caatttctcg aacaattcaa 1422541 agaaacaccg tctgcacaag aatttcagct tgaaagggaa aaattgaagg agcaaatcca 1422601 atcgctgcaa aaagagcttg aggatttgcg gagtgaaaat cagacattgc ggaatcagct 1422661 agagatgaca gaagaggatt acaaggcact gatcgatatc atggatcggg ccagaaaaat 1422721 ggttgtttcg aaggaagacg gaagaatgaa aaaagcggct caagaaacgt aaagaaacgc 1422781 ctgaaatgaa ccggccctat agtaagaata ggccggttgt tttgatttct atgcagactc 1422841 tcccggtgtc atttcgcgat ccatatcagg atgccagatg agcgggtttt cccctttgtc 1422901 ccgcgccata tcatacttaa cagttttaaa gttcattttg ttccaaaatt ccgctgattt 1422961 cattctcgga tttgtccgga tcggcatttt gaatgatttt gcaaattcaa ccaaggctct 1423021 cccgtatccc ctgttctggt agcccggaag aacctcaagc ttccacagct ccaaataatc 1423081 ctggcggttg tcaaaatagg gattcgattt gccgttaact tgatacagac tcattcgtgc 1423141 tacaagttta tcgccaaaat aaatcccgta aaaaggcgag gtgctgtcat tttcaataat 1423201 attatcctga agttcttcaa gcattgaaag ctcctgaatg ccgtattctt tgaatttctt 1423261 gaattcttcc agcgttttat agttgataag cagacgttct acctttgtca aacaaatctc 1423321 cccctttgtt gtttctacat atattgtaaa cgctttattt aaaaaatcca aatatttaaa 1423381 ctttaatttt aagcacatgg gatctttgag aagtaatttc ttcttacttc tgctatgata 1423441 atacgtaaat gctaaattgg gtgtgacatc atgaaaattg gaattatcgg cggaggctcc 1423501 gttggtcttt tatgcgccta ttatttgtca ctttatcacg acgtgactgt tgtgacgagg 1423561 cggcaagaac aggctgcggc cattcagtct gaaggaatcc ggctttataa aggcggggag 1423621 gaattcaggg ctgattgcag tgcggacacg agtatcaatt cggactttga cctgcttgtc 1423681 gtgacagtga agcagcatca gcttcaatct gttttttcgt cgcttgaacg aatcgggaag 1423741 acgaatatat tatttttgca aaacggcatg gggcatatcc acgacctaaa agactggcac 1423801 gttggccatt ccatttatgt tggaatcgtt gagcacggag ctgtaagaaa atcggataca 1423861 gctgttgatc atacaggcct aggtgcgata aaatggagcg cgttcgacga tgctgaacca 1423921 gaccggctga acatcttgtt tcagcataac cattcggatt ttccgattta ttatgagacg 1423981 gattggtacc gtctgctgac gggcaagctg attgtaaatg cgtgtattaa tcctttaact 1424041 gcgttattgc aagtgaaaaa tggagaactg ctgacaacgc cagcttatct ggcttttatg 1424101 aagctggtat ttcaggaggc atgccgcatt ttaaaacttg aaaatgaaga aaaggcttgg 1424161 gagcgggttc aggccgtttg tgggcaaacg aaagagaatc gttcatcaat gctggttgac 1424221 gtcattggag gccggcagac ggaagctgac gccattatcg gatacttatt gaaggaagca 1424281 agtcttcaag gtcttgatgc cgtccaccta gagtttttat atggcagcat caaagcattg 1424341 gagcgaaata caaacaaagt cttttgagct ttttcggtaa catgctatac tcatttcgga 1424401 tcactaacta tttattggag aaaggaagtt ctagaagatg cagctaactg aactttccat 1424461 caaaaatcag aatgtgtttg tacagcacta tatagatggc aaagaagaaa tgtcttcttt 1424521 ttttgattac agtattcatc ataaggacat gtggcgcgaa agactggaag acttatcttc 1424581 ccggtttttc gcaagagagg aattggcggc gtacttaacc tcttaccata ataaattcgg 1424641 ttcaagtgcg atgcagtctg ctattgagaa gctgaaggac ccgtcaagtg ccgctgtagt 1424701 cggcggacag caggcaggac ttttaacagg accgctttac accatacata aaatcatttc 1424761 aatcattgtt ttagcaaagc aacaagaaaa ggaactgcaa gtgcctgtca taccaatctt 1424821 ctgggtggct ggagaagacc acgatttgga tgagattaat tttgttcaca catctgaaga 1424881 gaatgggcct gtgaaaaaaa agctgcctca gtcttattgg aagaaatcat cagcagcgag 1424941 tacatcgctt gatcaggaaa agtgtgccgc gtggatagat gatgtttttg ccgcttttga 1425001 agaaacagac catacgaata cacttctcga caatgtgaaa cgatgtttaa gggaatctgt 1425061 tacgtttact gacttctttg aactgctgat cgcggatttg ttccaagaag agggcttagt 1425121 tttattaaat tctggggatc cggggattaa aaagctggaa acggccatgt tccaaaagat 1425181 tcttcgagaa aatgatgaac tcgcccgggc tgtatcagat cagcaggcct tcatgcgtca 1425241 agcaggctac aaaccgatta tcgagtccgg aaaagagcag gcgaatctgt tttatgaata 1425301 cgaagatgag cgttttttaa ttgaaaaaga taacggccga tttgtcatca aagagcttga 1425361 tctaggatgg acgagggatg aacttcatac acatatggaa gaacatccag agcgtttcag 1425421 caacaatgtt gtaacgagac cgttaatgca ggaatttctc attccgactt tagcatttat 1425481 tgcagggcct ggggaaatca attattgggg cgagctcaaa caggcatttg cggtgatggg 1425541 cttcaaaatg cctcctgtca tgccaaggct gaacattacg atacttgagc ggcatattga 1425601 gaaaaaactg gctgaacgga atatctcatt acaagacgcg attgagcgcg gaacggagaa 1425661 tcaaagagag acatacttcg agcgccagat tccggaagag tttacggcgg tgatggatca 1425721 ggcgaaaagc caaattgaag cgattcacaa aacggtccgg caggaggcgt taaaggttga 1425781 tcaaagcttg gaacctttac ttctgaaaaa tgccgctttt attcaggatc agcttcaatt 1425841 cttagagcgc acggtgatga agcgaattga agaaaaagaa ggctacgtct tgaaggatta 1425901 tgaaagaatt caaaatagca ttaagccgct tcttgcgccg caagaacgga tttggaatat 1425961 catgtattat ttgaacaggt acggtccaaa attcttcacg acattcaaga atctgccatt 1426021 ttcttttcaa aatcaacatc aagttgtcaa actttgaaat aaagttttaa agaaccctga 1426081 ctagttcagg gttttttttt atgggtaaac agtgtaaaat gaagttgtgg agcgaagtgg 1426141 tgaatagtgg tgagttaagg agagaaagtg gggcaagaga tcatgtttat gggtgaatat 1426201 cagcatacca tcgatgcgaa aggccgcatg atcgtacccg ctaaattcag agaaggccta 1426261 ggtgagcaat ttgtgctgac tagaggactt gaccaatgtc tcttcggcta ccctatgcac 1426321 gaatggaaac aaattgaaga aaaactaaaa gctcttcctc tcacaaagaa agatgcccgc 1426381 gcgtttaccc gtttcttctt ttcaggggcg actgaatgcg aactggataa gcaaggcagg 1426441 gtaaatatcg catcatctct attgaattac gccaaactgg aaaaagaatg tgttgttatc 1426501 ggggtttcta atcgaattga attgtggagt aaagtaattt gggaacaata cacagaagag 1426561 caagaagatt catttgctga aattgctgaa aacatgattg ggtttgatat ataatgattc 1426621 ttcgtgtata acactctaaa aacaatttca attcatcctg ataaaaggtg ggaccaacac 1426681 aatatgtttc aacacaagac agtacttctt cgtgaaaccg tagacggact taatattaaa 1426741 ccagacggta catatgtaga ctgcacactc ggcggagctg ggcatagtac atacttattg 1426801 cagcagttat ccgagaaggg gcgtttaatc gcttttgacc aagatgatac ggcattacag 1426861 catgctaaag aagtgttgtc cgattataaa ggacagctca ttctgattaa aagcaatttc 1426921 aggtatttaa aagaatattt gaatgaacaa ggcgttacag aagtagacgg cattttattt 1426981 gatttagggg tgtcctctcc gcagctggat acaccggagc gcggattcag ttaccatcat 1427041 gacgcaccgt tggacatgag gatggaccag tcggctacgc tttcggcgaa agaagtcgtt 1427101 aatgagtggc gctatgagga tctcgtccgt attttcttta aatacggaga agagaagttc 1427161 agtaaacaga tcgccagaaa aattgaggag gcaagaatga agtctcctat tcaaactacg 1427221 ggccaactgg tcgatctaat aaaagacgcg attcccgctc cagcgagaag gagcggggga 1427281 catcccgcta aacgcgtgtt tcaggcaatc agaattgccg taaacgatga acttagggtg 1427341 tttgaagaag ctttggagca ggcaattgag gttctgaagc cagggggcag ggtatcggtc 1427401 attaccttcc actcgctaga agacagaatt tgcaaaacca cttttaaaga aaagtcgtcg 1427461 cttccggaac ttcctccggg acttcctgtt ataccggaag agtttgaacc ggagctgaag 1427521 ctcatcacac gaaaaccgat tacggcatct caagaagagc ttgaagagaa caaccgggct 1427581 cgttctgcca agcttcggat tgctgaaaaa agaaaataac gaaacgcgaa cgcaaaatta 1427641 aaaggaggtc atcagcctat gagcaattta gcttaccaac cagagaaaca gcagcggcat 1427701 gcgatcagtc ctgagaaaaa agtgattgtc aagaaaaggg cttccattac tctcggagaa 1427761 aaagtgcttc ttgtcctctt tgctgcggcg gtgctcagcg tatcgctttt gatcgtatcg 1427821 aaggcgtatg cggcatatca aaccaatatt gaggtgcaaa agcttgagga gcaaatttca 1427881 tccgaaaata agcaaattgg tgacctcgaa aaaagcgttg ctgatttaag caaaccgcag 1427941 cgcattatgg acattgcgaa aaagaacggc ttgaatttaa aagataaaaa agtgaaaaac 1428001 atacaggaat gattcaaatg ccaaaaaaga ataaatttat gaatagagga gcagcgattc 1428061 taagtatttg tttcgctctc tttttctttg tcatcctggg gagaatggca tatattcaaa 1428121 taaccggaaa agcgaacggc gaagtgcttg cgacaaaagc gacagagcag catgaaaaga 1428181 aacggaccat cgaagcgagc cgcggctcga ttttagaccg aaaaggaaaa gtcattgcag 1428241 aggacacagc gacgtataaa ctgattgcga ttctcgataa aaaaatgacc actgatgtca 1428301 agcatcctca gcatgttgta aacaaagaaa aaacggcgga agcattgtct aaagtgataa 1428361 acttggacaa ggccgacatc cttgatatct taaataaaga tgcaaaacaa gtcgagtttg 1428421 gctcagctgg ccgggatatt acgtattcac aaaagcaaaa aatcgaaaaa atgaaactcc 1428481 cgggcatttc atttttacgg gatacaaaac gctactatcc aaacggagta tttgcatcta 1428541 atctaatcgg ctatgccgag gttgatgaag aaacaaatga aatttccggc gcgatgggat 1428601 tagaaaaagt gctggataag tatttgaagg agcgggacgg atatgtgaca tatgaaagcg 1428661 acaaatccgg ctgggagctc ccgaacagca aaaataaaat tacagcgcca aaaaatggtg 1428721 acaatgtata tttaaccatt gaccagaaaa ttcaaacctt tttggaagac agcatgacaa 1428781 aagtggcgca aaagtataat ccgaaaaaaa tcatggccgc agtcgttgat ccgaaaacgg 1428841 gcaaagtcct tgccatggga cagcgcccaa gctttgatcc gaacaagcgc gatgtgacaa 1428901 actactataa tgatttgatt tcatatgcgt atgaacccgg gtccacgatg aagatcttta 1428961 cactcgctgc tgcgatgcag gaaaacgtgt ttaatgcgaa cgaaaaatat aaatcaggga 1429021 catttgaagt tggcggagca cctgttaagg atcacaataa cggtgtaggc tggggtccga 1429081 caacatatca tgacggcgtc ctaaggtcgt cgaatgtcgc ttttgcgaaa ctggcgaaag 1429141 aaaagctggg atatgaccgc ctcaatcaat atttgcacaa attcaatttt taccagaaaa 1429201 caggtattga tttgccagga gaagtctcca gcaaaatcaa ctttaaatat gaatttgata 1429261 aggcgtcaac tgcatatggc caagcgtctg cggtcacacc aattcagcag attcaggccg 1429321 caacggcaat tgcaaatgac ggtaaaatga tgaaacctta tgtcattgac catatcgttg 1429381 accctgataa agataaaact atttatcaaa ataagccgga atcagccgga actccaattt 1429441 ctgcaagtac tgcgaaaaag gtgcgggata tattaggaga agtcgttaca tcgaagatcg 1429501 gaacagggca agcttataaa atcgaaggtt ttgatgttgc cgggaaaaca ggtactgcgc 1429561 aaatagccgg taaaggcgga tatttagacg gcacagataa ctatatcttt tcgtttatgg 1429621 gtatggcgcc aaaagatgat cctgagcttt taatttatgt tgctgtacag cagccgcaac 1429681 taaaagcagg acaaagcagt tcagatccag tatcagaaat cttcaatcca acaatgaaaa 1429741 atagcctgca ctacctaaac atcgaaccaa ctgaaaaatc tgactcagat aaggaagaaa 1429801 caaaagcgca gacaatgcct gatttaacag atcaaacggt agctgctgct caaaagaaag 1429861 caaaagagga gaatctcaca ccaattgtca tcggcagtga tgtcgctgta aaagaacagt 1429921 atccgaaagc ggatgaggaa gttctcacca atcaaaaggt cttcctgaaa acgggcggca 1429981 aaatcaaaat gcctgatatg acaggctggt cgagaagaga ggttctgcag tacggcgagc 1430041 tcgcgggaat tcatattgaa gtaagcggac aaggctacgc tgtcagccaa agtgttaaga 1430101 aagacaaaga aatcaaagac aaaaccgtaa tcaaggttaa gtttaaaaat cctgattaaa 1430161 aagaaagccg tcgttatgca ggctttcttt ttttatgcct tcagaggagc atcgttctac 1430221 ctgtccaaat tcaggcataa aatgaaacaa gcctaaataa ggagtgaacg gtctcttgcg 1430281 cgtctcgaat gtaacggtta gaaaacgttt attatttgtt ttgctttttg gcgtgatcgt 1430341 gtttctgatc attgatacaa ggctggggta tgttcagttt gtgatgggcg aaaaactgac 1430401 ttcgctagcg aaagattcct ggagccggaa cttgccgttt gagccggaga gaggcgagat 1430461 tctggatcgg aatggtgtga agctcgcaac aaataaaagt gcgccgaccg tattcgtcgt 1430521 gccgcgccaa gttcagaatc cgatgaaaac gagcaagcag cttgcggcgg tgctcaatat 1430581 gtcagaagaa aaagtatata aacatgtgac aaaaaaagcg tcaatcgaaa agatcactcc 1430641 tgaagggaga aaaatttcaa atgagaaggc gaaagaaatc aaagcgcttg atttaaaagg 1430701 tgtgtatgtt gcggaggaca gtatccgtca ttacccgttc ggcagctttt tatctcatgt 1430761 gcttggattt gcaggaattg acaaccaagg gctccttgga cttgaagcct attacgacga 1430821 tgatttaaaa ggggaaaaag gttctgttaa gttttataca gatgccaagg ggaagaagat 1430881 gcctgatgaa gcggatgact atacgccgcc taaggatggg cttgatatga agctgacagt 1430941 tgattcaaag gttcagacga taatggaaag agagcttgat aacgctgagg ccaaatatca 1431001 tccggacggc atgattgccg tagccatgaa tccgaaaaac ggagaaattt tggggatgtc 1431061 tagcaggcct gacttcgacc ctgctgatta ccaatctgtt gatccgtccg tctacaatcg 1431121 aaatctgcca gtatggagca cgtatgaacc gggatctacc tttaaaatta ttacacttgc 1431181 agcagccctt gaagagcaaa aagtaaattt gaaacgggat caattttatg ataaagggca 1431241 tgctgaagtg gacggagcga gactgcggtg ctggaaaaga ggcgggcacg ggctgcagac 1431301 gtatctggaa gttgtgcaga actcctgcaa cccggggttt gttgaattag gcgagcgctt 1431361 aggaaaggaa aagcttttca aatatatcaa agactttggt tttggacaaa aaacggggat 1431421 tgatctccaa ggcgagggaa caggcatctt attcccgctt gagagagtgg gcccggtgga 1431481 gcaagcaact acggctttcg gacagggagt atccgtcacg ccgattcagc aggttgcagc 1431541 agtatccgcc gctgtaaacg gaggaacgct ctatacacct tatattgcaa aggaatggat 1431601 cgatcctgtt acgaagaaaa cggtcaaaaa acaatcacca atcgcaaaga aacaagtcat 1431661 ttctgaggaa acatccaaac aaatccgcta tgctctagaa agcgtcgtcg cagaaggaac 1431721 cggccgcaat gcatttgtag aaggatatcg tgtcggagga aaaacgggaa ctgcacaaaa 1431781 ggttaaagat ggaaaatatc ttgaaaacaa ccatattgta tcatttatcg gtttcgcgcc 1431841 agcagatgat ccgagtctag tcgtctacgt tgcggtggat aacccgaaag gcacgattca 1431901 gtttggcgga acggtggcag cgcctattgt cggaaatatt atgagagaca gtctgccgga 1431961 acttggtgtg aagccccgga aaaatcaaat cgagaaaaaa taccaatgga acgacacaaa 1432021 aacaatagaa gttccgaatg ttgtagggat gtctgtctca gatcttgagt cactattggt 1432081 gaatctcaat gtggatgctt ccgggaaagg gagcaaaatc gttaaacaat cgccagctgc 1432141 cggaacgaaa gtaaaagaag gctcaaagat acgcgtgtat ttgactgaag aagatgaaaa 1432201 ggaggcagcc gattgattcg ggctgcctat tcttttattg cagaaaaaat gctgatatct 1432261 ttcaagatta gctggatgta tccttttatt tacgctaaaa tatgaactgt atgcttaaaa 1432321 tcattaccac atcatttgat gtgacttcaa tgataaaaag aacgaattag aatgttgaga 1432381 ggtttgatac gatgaaactt acaaagctgc ttacatactt aacaaccgaa ccttctgtaa 1432441 acgactcaca agaccctgaa ataacttcaa ttgagatgga ctccagggaa gtaaagaaag 1432501 ggagtctttt tgtatgtgta aaagggtata cggtggatgg ccacgatttt gcgcaaaaag 1432561 cagtagaaaa cggtgcagcg gctattgtgg cagaaagaga ggtcgatgtg aatgttcctg 1432621 ttattattgt ccggcagtca cttcgcgcgc tcagcgtttt gtctgatgcg ttttacggac 1432681 agccgacgaa gaagcttcag ctgattggga taacagggac aaacggcaaa acatcaacga 1432741 cccacatggt cgatgagatt ctgaaaaaag cgggaaaacg cacaggcttg atcggtacaa 1432801 tgtacatgaa aatcggagac gaaacacttc ctgttaaaaa cacgactccg gaaagcgtca 1432861 cgctgcagaa aacgtttaag aaaatgaatg acaagcacgt tgacactgca atcatggagg 1432921 tttcttccca cgctttgtct ttaggacgcg tccatggctg tgattatgat attgccgtgt 1432981 ttacgaattt aacacaggac catctggact atcataaaac gatggatgag taccggcatg 1433041 caaaaagctt gctcttttcc caacttggcg gggctttcaa ccatgaacat ccaaagcgtg 1433101 ccgtcctgaa tgctgacgat gaggcgagcg cttattttga aaaggtaaca gctgcgcata 1433161 tctctacata cggaattaaa aacgatgctg atgtgatggc gaagaacatc agtatcactg 1433221 cacagggcac aagctttgat ctcgtgacaa acaaaggcac gaagcacatc acgatgtctc 1433281 tcgtcggaca atttaatgtg tataacgtgc tggccgctgt tgcgacatgt attgcagcag 1433341 gcataccgtt tgaaatcatc actgaggctg ttgaagaatt gcatggtgta agaggccgtt 1433401 ttgaattggt caatcagcag caggagtttc ctgtcattgt agactacgcg cacacaccgg 1433461 acagccttga aaatgtgctg gagacatgca gagacatgac ggaaggaaag ctatttgtcg 1433521 ttgtcggctg cggaggagac agagataaga cgaagcgccc gaaaatggct aaaattgctg 1433581 tggagctggc tgacgagccg attttcacgt cagataaccc gagaagcgaa gatcctcgcg 1433641 cgattttaag agatatggaa gccggagtag agaacgcata ctatcacagt attgcaaacc 1433701 gcgagcaggc gatctttttc gcaattgcca atgccaaaaa aggcgacgtt gtcctcattg 1433761 ccggaaaagg acatgaaacc tatcagcaga tcggaaatga aactttcgat tttgatgatg 1433821 ctgaagtagc ggcgagagcc attgttgaac tcaataagaa taagacgaat tcataggaaa 1433881 gagatgttac tgaataatgg agcttgaaaa gatttttcat atggaaaaaa atcatgaata 1433941 tgataactac gtatgtcgtt tgaaagaaac aggaggagaa aaggacaatg cttgagcaag 1434001 tcattctgtt tacaatttta atggggtttt taattagtgt tctgctctct ccgattctta 1434061 ttccgttttt aagaagatta aaattcggcc agagtattag agaagaagga ccgaaatcac 1434121 atcagaaaaa atcagggaca ccgacaatgg gcggggtcat gatcatactt tctatcatag 1434181 tgacaacaat tgttatgaca cagaagtttt cagaaataag ccccgaaatg gtgctgcttc 1434241 tgtttgttac gctaggctac ggtttgcttg gctttttaga tgattacatc aaggttgtca 1434301 tgaagcgcaa tcttggattg acatcaaagc aaaagctgat cggacaaatt attattgcgg 1434361 ttgtatttta cgccgtgtat cattactaca attttgcgac ggatattcgc attcctggaa 1434421 ctgacttatc atttgatctt ggctgggctt actttatcct tgtgctcttt atgctagtcg 1434481 gcggatcaaa cgcagttaac ctgactgacg gccttgacgg gttattatcc ggtactgcgg 1434541 cgattgcctt tggcgccttt gccattctgg catggaatca gtctcaatat gacgtagcga 1434601 ttttctcagt tgccgttgtc ggtgcagttc tgggcttcct tgtatttaat gctcatccgg 1434661 ccaaagtttt tatgggagat acgggatcgc ttgcattggg aggagccatc gttaccattg 1434721 ccattttaac gaaattagag atcctgctgg ttatcatcgg cggtgtattc gttatcgaga 1434781 cattatccgt tattttgcag gtcatcagct ttaaaacgac aggtaaacga atctttaaaa 1434841 tgagtccgct tcatcaccat tatgagcttg tcggctggtc tgaatggaga gtagtcgtga 1434901 cgttttgggc tgcgggactt ttgcttgccg ttttaggaat ttacatcgag gtgtggttat 1434961 aagtggaaaa tgatcaattt ttacagaaac agcatttttt aatccttggg cttgcgaaaa 1435021 gcggatatgc ggcggcctcc attcttcatg aaaaaggcat ttatgttgca gtcaatgatc 1435081 aaaagccttt tgaagaaaat gaaccggcac aaaagctttc tgaaaaagga atcgaagttg 1435141 tttgcggaga gcatccagtt tctctgttcg atcagcatca aatcacgatt ctgatcaaaa 1435201 acccgggaat tccttatgaa aatatcatgg ttcaggaagc agagaaacga ggtattccgg 1435261 tttggacgga aattgagctc gcttactacc tgaccagcgc caagtttatc gggattaccg 1435321 gatcgaacgg taaaacgacc acgacaacgc taatttacga aatgctcaag gctgactcgc 1435381 aaaaagcact gattgccgga aacatcggca cagtcgcaag tgaggttgcc tatcatgctg 1435441 atggagatga atggatcgtt accgaactgt cttcgtttca gctgatggga acacacgctt 1435501 tcagaccgga aatcagcctg attttaaatg tatttgacgc ccatctggat tatcaccata 1435561 cgcgcgaaaa ctatgaaaaa gcgaaacaga aagtgtacct tcatcagact gcttcagata 1435621 aagctattgt caaccaggat gatgaaaccg tcgtgcgtct tgctgaagcc ggaaaagccg 1435681 aaatcgtccc attttcagtc agcaaaacgc ttgaacaggg cgcatatgta aaagacagta 1435741 tgattatgtt taacggcgaa gccattcttc ctctggaaga ggttgtactg cccggtgctc 1435801 ataacctgga gaacatttta gcagctattg cagttgtgaa aacggcagga gcatccaatg 1435861 aggcggttaa aaaggtgctg acaagcttta ctggtgtgaa gcaccgcctc caatatgtca 1435921 caactgtgaa tggccgcaaa ttttataacg acagtaaagc aacaaacatt ctggcgacaa 1435981 gcaaggcgct ttcagctttt gataagccgg tcattctgct tgcgggcgga ctggatcgcg 1436041 gaaatggttt tgatgacttg aaaccttata tgaagcatgt caaagcagtg cttacatttg 1436101 gccagacggc gccaaaactc gagaaactcg gcaatgaact gggaatacaa catgtcaaac 1436161 gtgtcgataa tgttgaacaa gcagtatctg cggcgtttgc gctctcaaat gaaggagatg 1436221 tcatcctgct gtcacccgcg tgtgcgagct gggatcaatt caaaacattt gaagaacgcg 1436281 gtgacatgtt tatagatgcc gtgcatatgc ttaagtaagg gcttgtcttg aagtaaatcg 1436341 gcagccctaa tgactttaag cttggggtgt cgattgcttt gactactaaa aaaacatcgc 1436401 ctgatttgtt attggtcatc attacgttat tattattaac aatcggatta attatggtgt 1436461 acagtgcgag tgcggtatgg gcggattata aatttgacga ctcattcttt ttcgcgaaac 1436521 ggcagctttt gtttgcggga atcggcgtca ttgctatgtt ttttatcatg aatgttgatt 1436581 attggacttg gaggacatgg tccaaattgc tgatggttat ctgctttttc cttctggtgc 1436641 ttgttttgat accgggcgtc ggaatggtgc ggaacggttc aagaagctgg atcggagtcg 1436701 gagcattcag catacagcct tcagagttta tgaagcttgc gatgattgca ttccttgcta 1436761 aatttctctc tgaaaaacaa aaaaacatca catcgttcag acgggggttc gtccctgcac 1436821 ttggcatcgt gttttcagca tttttgatta tcatgtgcca gcctgacctc ggaacgggga 1436881 cagttatggt cggaacttgt attgtcatga tttttgtagc cggcgcacgg atcgcccatt 1436941 tcgtctttct cgggctgatc ggcctcagcg gatttgtcgg gctcgtacta tcggctccat 1437001 atcggataaa gcggattacc tcatacttaa atccatggga agacccgctc ggaagcggat 1437061 ttcagatcat tcaatcgctt tatgcagtgg ggcccggcgg gttgttcgga atggggctcg 1437121 gacaaagcag acagaagttc ttttatctgc ctgagccgca aacagacttt attttcgcca 1437181 tcttgtcaga ggagctgggc tttatcgggg gaacacttat tttgctcctc ttcagcgtcc 1437241 tgctgtggag aggaatcaga attgcgcttg gtgcgcctga tctgtacgga agctttgtcg 1437301 cagtcggcat tatttcaatg attgccattc aagtcatgat aaatatcggc gtagtcacgg 1437361 gcctgattcc tgtaacaggc atcacgctcc cgtttctgag ctacggaggc tcttcattga 1437421 ctctaatgct gatggcagtt ggtgtgctgc tgaatgtaag ccgctactcg aggtattaac 1437481 gaatgtattt ccaagcctcc tgtctaacat gaagcttgga aacaattgat gcgataaccc 1437541 tgtccaacaa aacagggtta tcgttatgtt atagagaaac ttagactggg ggaaaaaaga 1437601 aatgcgaatt gcaataagcg gaggcggtac agggggacat atttatcctg ctcttgcttt 1437661 tattaaagaa gtgcaaagac gtcatcctaa tgtggaattt ttatatatcg gaacagaaaa 1437721 cgggctggag aaaaaaattg ttgagcggga gaatataccg tttcgttcaa ttgaaattac 1437781 aggatttaaa agaaaattgt catttgaaaa tgtcaagact gtgatgcgtt ttctgaaggg 1437841 cgtcaaaaag agtaaatcgt atttagcgga atttaagccc gatgccgtaa ttggaacggg 1437901 cggttatgta tgtgggccgg ttgtctatgc cgctgcgaaa atgggaattc cgactattgt 1437961 ccacgaacaa aacagcctgc cgggcatcac gaataagttt ctttcaaaat atgttaataa 1438021 agtagcgatt tgttttgaag aagcgaaatc acattttcct agcgagaaag ttgtatttac 1438081 gggaaacccg agagcctctg aagtcgtctc aataaagacg ggacgatcat tggctgaatt 1438141 tgggctttct gaagacaaaa aaacggtctt aattttcggc ggaagccgag gcgctgcacc 1438201 gattaaccgc gctgtcattg acatgcagga tgtgctgaaa acaagagact atcaagtgct 1438261 gtatatcacc ggtgaagttc actatgaaaa agtaatgaat gagctgaaaa gcaagggtgc 1438321 cgctgataat atggtcacaa agccgtttct tcatcaaatg cctgagtatt taaaggccat 1438381 tgatgtcatt gtggccagag ccggtgcgac aacgattgcc gaaattactg ctctcggaat 1438441 cccaagtgtt ctgatcccaa gtccatatgt gacagcgaat caccaggagg tcaatgcgag 1438501 gtctcttggc cagcatgatg cggcgattgt actgaaagaa acagagctca gcggggagaa 1438561 gctgattgaa gcgctagacc ggattgtact gaatgagcaa acgttaaagg aaatgagcga 1438621 acgaacaaag tcactcggtg ttcctgacgc ggctgcccgt ttatacagcg tactcgagga 1438681 attaaaaaaa tagtagaaaa gcaaatggaa tgcggaggtt tacgatggag aaagtgatac 1438741 aggaattaaa agaacgagaa gtcggcaagg ttcttgcaaa tgaaccgctc gcgaatcata 1438801 caacgatgaa aatcggcgga cctgcggatg tattggtcat tccaagcagt gtggatgctg 1438861 ttaaagacat catggacgtg attaaaaaat atgatgtgaa gtggacagtc atcggccgcg 1438921 gatcaaatct tcttgtttta gatgaaggaa ttagaggcgt agtgatcaag ctgggggcgg 1438981 gtcttgacca tttggagctt gaaggggaac aagtaacagt cggaggcggt tattcggtgg 1439041 tccgccttgc tacatcattg agcaaaaaag gcctgtccgg tttggaattt gctgccggca 1439101 ttccaggatc agtcggcgga gcggtttata tgaatgccgg cgctcacggt tctgatatga 1439161 gcgagatcct cgtcaaagcg catattttat ttgaagacgg aacgattgag tggctgacaa 1439221 atgagcagat ggatttcagc tacaggacat ctgtactgca aaagaaacgc ccgggcgttt 1439281 gccttgaagc tgttttgcag cttgagcaga aggataagga atcaatcgtt cagcaaatgc 1439341 aaagcaataa agactataga aaaaatacac agccgtattc aagcccttgt gcgggaagca 1439401 tattcagaaa tccgcttccg aatcatgccg ggaaccttgt agaaaaagca ggcttgaaag 1439461 gatatcaaat cggcggtgca aagatatcgg agatgcacgg aaacttcatc gtcaatgcgg 1439521 ggggagcatc agcaaaagat gtgcttgatc tcattgacca tgtgaaaaag acaatccgtg 1439581 aaaaatacga gattgatatg cacacagagg ttgaaatcat cggcggaaat cgctgattca 1439641 agttctgact gaagctgttc atatgatata ctgtaagcaa acgacaaacg gcatcatagt 1439701 atgccgtttg ttttggaata gacagacttt taacagctgt ttcatttgaa tgaggtgaac 1439761 aggcaatgaa cccgggtcaa gaccgagaaa aaatcgttaa cattgaagag cggatcccta 1439821 aaattaaaga gcagaggaaa caaaaggcaa accgccgtct catttcattt attatgctct 1439881 tttttattat ggtgctgatc attgtgtacc tgcaaacacc aatcagtaaa gtatcaacaa 1439941 tctctgttac agggaatgaa aatgtatcaa aaaaggaaat tatcgacctt tccgatatta 1440001 acagcggaga tactgagttt tggagtttgg acaagcaaaa aacagaaaag aagattcagc 1440061 aaaataaatt agtgaaaaaa gcggagatca gcaaatcgct tcctaataaa atcaacattg 1440121 caatcgaaga atataaagcg attgcttatt tagaaaaaga cgatgtgtac tatgaagtgc 1440181 ttgaaaacgg ctcagttctg ccaaacgaag taacgccgga tgatgccgga ccgattttag 1440241 tgaattggac aaacgcgaag aagcggtctc aaatggccaa gcagctcgat gcgttgtcaa 1440301 attcgttaaa acagtcgatt tcagaaattt attatacgcc tgtaaaaatg gatgaaaacc 1440361 gtattaagtt gtacatgaac gacggttatg ttgttacggc atctattaaa acgtttgcag 1440421 accgaatgaa gacgtatcct tctatcatct cacagctaag cagcaataaa aaaggaatca 1440481 ttcatttaga agttgccacc tattttgaag agtttgggaa aaacgataaa gctgctaaaa 1440541 aggaagatga aaattgaggg gcaaatcagc agtccttctt tccttgatta tgcttatcgc 1440601 aggttttttg atttcatttt cttttcaaat gacaaaagaa aacaacaaaa gcgcggctga 1440661 gacggaagag tggaaaaaag aatatgcgct gagagatgaa ctgctgaaac aagagaaaga 1440721 aaataagaag tttgaaaaag aattatatca aaagcaaaac aaagtccgcc aggcggaaaa 1440781 taagctgaag aaagagaagt cggaatacta taatgtcctc gaagatacag aaaaatacag 1440841 gatgtatatt ggggaagtcg gtgtgcaggg agaaggcgtt gaggtgacat tggaagatgc 1440901 gtcatacata ccggaagggg agaatgtgaa tagttacatc gttcacgaaa gccatatctt 1440961 ccaagtagta aacgaactgt atatctcagg agcggcagct gtcgccgtta atggacagcg 1441021 tttgacgcat gattcgtata tcaaatgcaa tggtcctgtg gtaacggtag acggggtgca 1441081 gcatcccgct ccgtttacgg tatccgctat tggagatcca gatgtcctgc tgccctcgtt 1441141 aaatatcgct ggaggcctaa ttgatcagct gtcaatggat catatttctg tgtcggcaga 1441201 aaaagagaaa aacgtacaaa tgaaaccgat tctgaaaacg aaggaatgac tgaaaaagcg 1441261 ggtgaaatag attgaaaata aagcgttcct tcataagcat cagtgttctt atggtcatct 1441321 tcggcctgat gatatctgtt cagtttaatt cgttaaagca ccccaaagtc cgggatacaa 1441381 gagatatgtg ggatattagg gaagagctga catcagagca gaagaagcag gaaaagctgc 1441441 tggctgaaat aaacaaatat gacaaattgc tgaatagcta ttcgcaaacg aaagaaatga 1441501 caaaagaaac cgcgctaaat aataccttgc aatccttaaa aaaaacagcc ggcatgaccg 1441561 atataacagg tagcggaatt gtcattacga tttccccgct tttttctgaa agcttaacag 1441621 gagagccgat cgaaaatccg cctccggatt tgctgaaaaa gctgataaat gaactcaact 1441681 cctacggtgc agagcatatc tcgattaatg agcgaagagt tgtgaatcat acagtcatca 1441741 gagatataaa cggcactaca aaaatagacg gatacgccct tgacgattat cctttaacag 1441801 taaaagtgct tgccaaagat ccggacatgt tacacagcag agtgaagggg tcaggccttg 1441861 aggatctttt tgcatctgaa aatttagcat taaaagccgg taaatctgaa agcaaactaa 1441921 cattaaaagc atatgacaga ccactggacg tacaacagct gaaactgctt aaagactgaa 1441981 aaggaggaga attgtcatgt ggctgcccgt gttgggactg gtgctcggaa tagcgattgg 1442041 actaatgaca aacttaacga taccgagtga atactcaaac tatttatcgc ttgcggtgct 1442101 tgccgcactt gatacattaa tcggcggaat cagggcgcat ttacaaggta catatgatga 1442161 aatggtattt gtttccggtt tcttttttaa tattatattg gcaataagtt tagcttttct 1442221 gggagtccat cttggtgtag acttgtattt agcaggtata ttcgcatttg gagtcagatt 1442281 atttcagaat atagccgtta tcagaagaaa tctactaaca aagtggactc tttctaaaaa 1442341 aaataaaaaa aatgtgatat aaaagaggat atacatagga tataacgaat attttcaata 1442401 aacataaaat gtgaaaagca cataaaaata ttctgttgtt attttttgtt acacacttgt 1442461 aaagccacat tcattgtatt gttgttccgc aaataataga atagaaatga tcgaaatgtg 1442521 aggaggtgcc atagaatgaa caacaatgaa ctttacgtca gtcttgacat cggtacgtcc 1442581 aatacaaaag tgatcgtcgg agaaatgaca gatgattccc ttaatattat cggtgtggga 1442641 aatgtaccgt ctgaagggtt gaaaaaaggc tcaatcgttg atatagatga gaccgttcat 1442701 tctataagaa aagcgtttga ccaagctgaa agaatggtag gttttccgct tagaaaagct 1442761 attgtcggcg ttaatggaaa ttatatcaat attcaagata caaacggtgt tgtagcagtt 1442821 tccagtgaaa ataaagaaat tcaggttgaa gatgtacgcc gtgtcatgga ggcggcacag 1442881 gttgtttccg taccgcatga acagctgatt gttgacgtca ttcctaaaca gtttatcgta 1442941 gatggaagag atgaaatcac cgacccgaaa aaaatgctgg gtgtgcgttt agaagtagag 1443001 ggcaccttga tcaccggttc aaaaacaatc ttacataact tactccgctg cgttgaaaga 1443061 gctggtattg aaataactga tatttgcctt cagccgctgg cagccggttc tgctgcatta 1443121 tcaaaggacg agaaaaacct tggtgtggct ctcattgata tagggggagg gtcaacaacc 1443181 attgccgtat tccagaacgg acatctcact tctacccgtg tcattcctct cggaggcgaa 1443241 aatatcacca aagatatctc catcggattg agaacgtcaa cagaagaagc agaacgcgtg 1443301 aaaaagcaac ttggacatgc ctactatgac gaagcctcgg aagatgaaat atttgaggta 1443361 accgttatag gcaccaatca aaaacaaaca tttacacagc aagaagcagc gaatatcatt 1443421 gaagcgagag tagaggaaat tcttgaaatt gtttcagaag agcttcgcag tatgggaatt 1443481 accgatctgc cgggaggctt cgtgctgaca ggaggacaag cagctatgcc gggtgtcatg 1443541 tctttggcac aggatgtgct gcaaaacaat gtcagagtgg caagcccgaa ttatatcggt 1443601 gtaagagatc ctcaatatat gacgggagtg ggcctgatcc aattcgcctg ccggaatgca 1443661 agaatccaag gcagaaaaat aggctttaag atgcctgaag aagcgataca ggaaatcgca 1443721 gtctcatcat ctgaggaaca agagcagcat catcaccaaa atgaggtgca gcagcggcca 1443781 aaaggaaaac aaaaaacaca agccgaacat aataaacaga gcaaaatgaa aaaactatta 1443841 agcatgtttt gggaatagat agatagtcat tcggcagatt aggaggattt agcatgttgg 1443901 agttcgaaac aaacatagac ggcttagcat caattaaagt aatcggagta ggaggcggcg 1443961 gtaacaacgc cgttaaccga atgattgaaa atgaagtgca aggagtagag tatatcgcgg 1444021 taaacacgga cgctcaagct cttaacctgt caaaagcaga agtgaaaatg caaatcggcg 1444081 caaagctgac tagaggattg ggagcaggtg cgaatccgga agtcgggaaa aaagccgctg 1444141 aagaaagcaa agagcagatt gaagaagcac ttaaaggtgc tgacatggta ttcgtgacag 1444201 ctggtatggg cggcggaaca ggaacaggtg ccgcaccggt tatcgcacaa atcgcgaaag 1444261 acttaggcgc attaacagtc ggcgttgtga caagaccgtt taccttcgaa ggacgcaaaa 1444321 gacagcttca ggctgcaggc ggaatctcgg caatgaaaga agcggtggat acactgatcg 1444381 tgatcccgaa cgaccgtatc cttgaaattg ttgataaaaa cacaccgatg cttgaagcat 1444441 tccgcgaagc ggataacgta cttcgccaag gggttcaagg tatttctgac ttgattgcta 1444501 cacctggtct tatcaacctt gactttgctg atgtgaaaac aatcatgtca aacaaaggat 1444561 ctgctttgat gggtatcggt attgctactg gggaaaatcg cgcggcagag gcagcaaaaa 1444621 aagcaatttc cagcccgctt cttgaagcgg ccattgacgg tgcgcaaggc gtcctcatga 1444681 acatcactgg aggaacaaac ctcagcctat atgaggttca ggaagcagca gacattgtcg 1444741 cttcggcgtc tgatcaagac gtaaacatga ttttcggttc tgttattaat gaaaatctaa 1444801 aagatgagat tgtggtgaca gtgattgcaa ccggctttat cgaacaagag aaggacgtga 1444861 cgaagcctca gcgtccaagc ttaaatcaaa gcatcaaaac acacaatcaa agtgttccga 1444921 agcgtgagcc aaaacgtgag gaacctcagc agcagaacac agtaagccgt catacttcac 1444981 agccggctga tgatacgctt gacatcccga cattcttaag aaaccgtaat aaacgcggct 1445041 aatgtaaagg acaaaatcgt tttcgatttt gtcctttttt gtttttctct tcacactttc 1445101 cttcttataa agtctttttc cctattgctt ccttcgcgag ctcgattatg gatggtttac 1445161 gttttggaaa aagtaaggta tcctagttcg tacaaagttt tatgaaaatt aaaacaatta 1445221 taaaaggcaa taaagaggag gaccacgatg attttgcagc ttgacaatgt ctcactaaaa 1445281 cggaatggga aatggatact gaaagatatt cattggaagg tggaagaaaa ggaaaattgg 1445341 gtgctttacg gcctaaatgg cgccgggaag acagcgctgt taaatatgct ttgctcatat 1445401 tattttccaa catcaggcga gatgcaggtg ctcggccatg aatttggcaa aacagagctt 1445461 ggggaaaagc tcagacgtaa aattggcctc gtctcagcag ctcttcagca aaaattgtat 1445521 ccggcagatt cagcttttga aattgctttg agcggagctt acgcttcgat tgggttatat 1445581 gaaacgccaa gtaaggaaac cagggaaaaa gcgataggtt tgttagagga cttgggagca 1445641 attgaatatg ccgatcgccg ctatgaaacc ctttctcaag gggaaaaaca aagagcattg 1445701 attgctagag cactaatggc cgatccggag ctgctgatac tggatgaacc agtcacagga 1445761 ctggatttta ttgcccggga aaagctgtta gatacgatta catacattgc aaacaaagaa 1445821 aatgcaccat ctatccttta tgtgactcat catgctgaag aaattttgcc tgtctttgat 1445881 aaagcccttt tattaaaaca gggagaggtt tttggatccg gagaaataaa ggaaatgctt 1445941 actgatcaaa tactttccgc tttttttgat acgccaatcc atgtattatg gaatcaggat 1446001 cggccgtttt taacaagagc tgagccgata acgaatgcct gacaaatata tatagattca 1446061 tcctaggggt gctttgcgaa gctgagagag actttgtctc aacccttttg acctgatctg 1446121 gatcatgcca gcggagggaa gcggtgaaaa gcggagtaca tcggactccg tttgttttta 1446181 ttaagccgtt tcatcacatt tgaaacggct tttttgattt taaagaatag gagcggattt 1446241 acattggatc aacaaatata ctctttgcaa aaaaaagtgg aagaacataa ggaggagctt 1446301 attcagcttg cgaaaacgct gatttcttat caaacacctg ctccgcctgc aagaaataca 1446361 gagggcattc agtcttggat tgcgggatat ttaaatgaat tgggattctc gatcgacaaa 1446421 tgggatgtgt accctggaga tcccaatgtt gtagggaagc taaaaggaac agattcagca 1446481 gattattata gcctgattat caatggccat gtagatgtgg cagaggtaaa agaggatgaa 1446541 gaatggaagc acgatccgtt tcatcccatt gaaaaaaacg gtctcttaat cgggcgaggc 1446601 gcttccgata tgaagggcgg aatggcttgt gtgctgtttg ctgtcaaatt aattcgtgaa 1446661 gcaagcattg aacttccagg tgatctgatt ctgcaatcgg ttattgggga ggaagttgga 1446721 gaggccggca cacttgaatg ctgcaagagg ggctaccacg ctgattttgc aattgtcgcg 1446781 gatacgagcg atatgcatat tcaaggccaa ggcggtgtca ttacaggctg gatcgaaatc 1446841 aaaagcagtc aaacatttca tgatggaacg agacggaata tgattcatgc aggcggagga 1446901 acattcggag caagcgcaat tgaaaaaatg gcaaaaatca ttgcggggct cggtgaactt 1446961 gagcgccact ggtctattat gaaaagttat cccggtttta aaccaggcac aaatacgatt 1447021 aacccggcag ttatagaagg cggcagacat gcggctttta tagcggacga atgccggctg 1447081 tggatcacag tccattttta tccgaatgaa acccatgacc aagtggcagc ggaaatagaa 1447141 gattacgtca atcggctgag tgacagtgat atttggctta gggaaaaccg ccctgtattc 1447201 aagtggggag gctcatctat gatagaagac aggggagaaa tttttccggc attggaagtt 1447261 gaccctggcc acccaggcgt cttagcgcta actgcctctc atcagaaagt gaaacgggag 1447321 tgtccaatta ttgacgtttc tcaatcagtt acagatggcg gatggctgta tgatgccggt 1447381 attccatgcg taatatacgg tcctggagat ctgcacaatg cacactctgt gaacgagaag 1447441 gtatcgattg agcagctagt agagtataca aaaattatac tcgattttat catcagctgg 1447501 tgcagccgga aaaaagaaca atgacatgaa aatttcttct tgctgacaag gttcagcctg 1447561 cccgttcata tacttgaaca aaaggacgga aaaaggacgt gatggaatga tcagcatttc 1447621 agaatttcag gtaaaggatg tcgtcaatgt ctcaaacgga aaaaagctgg ggagtattgg 1447681 tgatattgat atcaatgtga ccactggaaa aattcaggcg atcatactcg gaggaaatgg 1447741 gaaagttctc ggattttttg gaaaagaaga ggaattggtc attccatggc gaaatatagt 1447801 aaaaatcggg gaagatgtaa tcttagtccg attaagtgaa ccacatgcat aaacctgctt 1447861 gtctgccgca gattggcaaa tgccggaagt ctcgattctt ccggcacatt tcatttagaa 1447921 atatgcaaat cggcgctcaa cgaatgcagt aagatgtggt aaaataagtg ggaaattccg 1447981 cttttttaaa tgtttgtcga aaggttggat catcatgaat acatatcacc cattcagtct 1448041 taccacaccc tcgacactca tgatacaaga ctgggctcaa acgaatcaaa acaacaaaga 1448101 ggtcattgcc ggatttacga caaaaaacgg cggtgtcagc caaaagcctt ttgaatcgtt 1448161 aaatacagga ttgcacgttc atgacaaaga tgcagatgta gttaaaaatc gtgaatatat 1448221 tgccgatatg tttaatactg atttgcagtc ttgggtattc gctgatcaga cacatgataa 1448281 tcgcgttcag aaagtgacgc agagggatag gggaaaaggc gcccgtgagt atcacacggc 1448341 tctaaaagca acggacggga tctatacaaa tgaaaaaaat gtatttttag cattatgctt 1448401 tgctgattgt gtgcctcttt tcttttatga tccggttaag tcgcttgtcg gagtcgccca 1448461 tgccgggtgg aaaggcaccg tcaaacagat tggcagagaa atggtgaagc aatggactga 1448521 gaaggaaggt tcaaatccct cagatattta cgctgttatt ggcccgtcta tcagcggagc 1448581 atgctatacg gtagacgacc gcgtcatgga tgctgtccgc gcattgccgg tttcagcaga 1448641 ccttgccgcc aatcagacgg caaaggcaca atatcagctt gatctgaaag agctgaaccg 1448701 tcttatactg atggacagcg gtttggcaag tgaacaaatt tctgtcagcg gtttatgcac 1448761 ggaaagcgag ccgtctcttt tctattctca tcgccgcgat caggggaaaa ctggacggat 1448821 gatgtccttt atcggaatga aggaggcata aaagatcttg cgtgttgttg ataatttacg 1448881 acatataaac gaacgaataa acgaagcatg taacagatcg ggccgcagct ccgatgaagt 1448941 tacggttatt gcagtcacaa aatatgtatc acctgaaaga gcacaggagg cagtagatgc 1449001 tggcatcacc tgcctcggag agaatcggga tgcggaactg ctccgcaaac aggaattgat 1449061 gaaagggaat ccggaatggc attttatcgg cagtctgcaa tcaagaaaag caaaatctgt 1449121 cgtcaattcg gtttcctata tccattccct agaccggctc tcattagcga aagaaattga 1449181 aaaacgggct gaaggtactg tacgatgctt tgtgcaggtc aatacctctc ttgagccttc 1449241 taaacatggc atgaaaaaag aagaagtcat tccattcata caggagcttt ccggtttcga 1449301 acatatcctt gttgccgggc tgatgacaat ggctccgctg actgatgatc aagatcagat 1449361 cagaagctgt ttcaggtcgc tgagagaact ccgtgaccag gttcagaagc tgaaccagcc 1449421 gaacgctccg tgtactgaac tgtcgatggg catgtcaaat gattttgaaa ttgcaattga 1449481 agaaggagct acttatatta gaatcggctc atcgttagtc ggaaatgaaa cagggggtgt 1449541 acagcaatga gtatgaaaaa taaactgaaa aactttttct caatggaaga tgaagaatac 1449601 gaatatgaat atattgagac agagcgggaa tctcatgagg agcatgagca aaaagaaaag 1449661 ccggcttaca acgggaataa acctgcgggc aaacagaatg tagtgagctt gcaaagtgtt 1449721 cagaaatcct ctaaagtggt gttgagtgag ccgcgcgttt atgcggaggc gcaggaaata 1449781 gccgaccatt tgaagaaccg gcgggcagtt gtcgtcaatc ttcagcggat acagcatgac 1449841 caggcgaagc ggattgttga ctttttaagc ggaaccgttt atgccattgg cggcgatatt 1449901 caaagaatcg gctcagatat tttcctctgc acgcctgaca acgtagatgt atcaggcaca 1449961 atttctgagc tcatatctga agacgaacat cagaggtggt aaagcgagat gatcctttat 1450021 caagtttttt cggttttaag cttattaatc acaatatact catttgccct gatcatatat 1450081 atttttatgt catgggtgcc gagtacgagg gaaacagcag tcgggcgttt tttggcttcg 1450141 atttgtgaac catatctcga accattcaga aaaatcatcc ctccgattgc aatgctggat 1450201 atttcaccaa tcgtagcaat acttgtgctt cggtttgcga caaccggctt gtggggactt 1450261 tatcgcatga ttgcgtttta atgtgacagt ttgatagggg cttggcagca gccaagcctc 1450321 tttacataga agggaaagac gatgagcgat atatatcagc acttcagaaa agacgagcgg 1450381 gcctttattg atcaagcgct cgaatggaaa agaattgtcc aggagcagta ccggatgaag 1450441 ctgaccgact ttttagatcc ccgagagcag gtcatcctct ctgctgttac gggacaggca 1450501 gatgtcgggc ttgccttttc cggcggctat gacagagcgg agcggaaacg ggcgattctg 1450561 tttccagagt acattactcc ggaagaatca gattttgaac tgcaggcgtt taacgtccgt 1450621 tatgctgaca agtttgtctc agtagatcat cgttctctgc ttggtgcatt aatgggcata 1450681 ggattaaagc ggcaaaaatt cggtgacatc gtgttttctg agacagcagt gcaattgatt 1450741 gtctcagccg ataccgctga ttttgtggct gcacagctga cccaagcagg caaagcggcg 1450801 gtcagcctag agaaaatcga cttgtcagac cttaacattc cagcagttga tgtcgaaata 1450861 agagatgaca cggtttcttc tttaaggctt gacgccgtct gcgcctctat gagcaggcaa 1450921 tcccgccaga aatcacagac gcttgtgaaa aacggccttg tgaaagtgaa ctggaaggtg 1450981 gttgaagatc cttcatacat agtcgcggaa ggggacatgc tgtctatcag aggttttggc 1451041 cggtgcagct taacaaaaat cgaaggaaaa accaaaaaag acaaatggag agttacgttt 1451101 gaacgacaaa aatagtcggt ttttcagttt ttttctccat ctgtgcgaaa tttgttttat 1451161 aatgtgaact agataaccgt actgaaatgt aaaaatggag gtggcatcat gccattaacg 1451221 ccaaatgata ttcacaacaa gacgtttaca aaaagttttc gcggatatga tgaagatgaa 1451281 gtaaatgaat tcctagccca agtcagaaaa gattacgaaa ttgttctccg caagaaaact 1451341 gagcttgaag cgaaagtcaa tgagcttgat gaaagaatcg gacactttgc caatattgag 1451401 gagacattga ataaatcaat tttagttgct caagaagcgg ctgaagacgt aaaacgcaat 1451461 tctcaaaaag aagcaaagct gatcgttcgg gaagcggaga aaaacgctga tcgcattatc 1451521 aacgaatcgt tatcaaaatc aagaaaaatt gcaatggaaa ttgaagagct gaaaaaacag 1451581 tctaaagtgt tcagaacacg tttccaaatg ctgattgaag ctcagcttga tcttctgaaa 1451641 aatgacgatt gggatcatct ccttgagtat gaagtcgacg ctgtatttga ggaaaaggaa 1451701 taaattctct gattatcttg acattttctt agcttgtcga atataatacg ttcataaatt 1451761 cagatgaaaa aacggttgaa agggacagtc atgtttcctt caggccttca tagcgacccg 1451821 gagatggtga gagtccggga tggccggaat catgtagatc agccctttag tttccttgct 1451881 gaactcacag taggttagga cgttcatcac gttacgatgc tcaagaggaa aaagtgtatg 1451941 cttgcttttt ctaaaagggt ggtaccgcga gataagcttt ctcgtccctt atgggatgag 1452001 agggcttttt ttattttctg aaaaaatgca gtggaggaat gaaaatggat tttaaagaca 1452061 cgctcttaat gccgaaaaca gatttcccga tgcgtggaaa tttgccaaac cgtgagcctg 1452121 acattcaaaa aaaatgggag gaagaagata tctaccgtct tgttcaggaa cggacgaaag 1452181 accgcccgaa atttgtttta catgacggac ctccgtatgc aaacggcgac atccatatgg 1452241 gccatgcact taacaagatt ttgaaagact tcattgtccg ctataaatca atgagcggct 1452301 acaacgcacc gtatgtgccg ggctgggata cacacggatt gccaattgaa acagctctga 1452361 caaaaaacaa aaaggtcaac cgcaaagaaa tgtcagtagc ggaattccgc aaactatgcg 1452421 aagagtacgc ttggaagcaa atcgagggac agcgtgagca attcaaacgt cttggtgtcc 1452481 gcggtgactg ggaaaaccca tatgtgacat taaaaccgga atacgaagcg cagcaaatcc 1452541 gcgtatttgg tgaaatggca aaacgaggct acatttacaa aggccttaaa ccggttaact 1452601 ggtcaccttc aagtgagtct gctctggctg aagccgagat cgaatatcaa gataaacgtt 1452661 cagcatctat ttacgtcgct tttggtgtaa aagacggaaa aggcgttctt gaaaacggcg 1452721 agcgcatcat catttggaca acaacgccgt ggacaattcc ggcgaacctc ggaatctcag 1452781 tgcaccctga tcttgagtac agcgtgattg cagtaggtga agaccgcttt gttgtagcaa 1452841 gtgccttagt cgaaaatgtt gcatcggcat gcggatttga tcagtatgaa gtgacaagaa 1452901 cggtcaaagg gaaagacctt gagaacatta tcgctgaaca cccgctatat ggcagagact 1452961 ctctcgttat gcttggtgaa cacgtaacaa ctgatgccgg aacaggctgt gttcatacag 1453021 cgcctggaca tggggaagat gactttatca tcggccaaaa atacggttta gatgtgcttt 1453081 gcccggtcga tgaaaaaggt gtaatgacaa gcgaagctcc tggctttgaa ggcatgttct 1453141 atgatgatgc aaacaaagcg atcacacagc agcttgatga aaaaggcgca cttgtgaagc 1453201 ttgaattcat tactcattct tatccgcatg attggagaac aaaaaaacca accattttca 1453261 gagcaacagc gcaatggttt gcgtctatta aagatttcag atcagacctg ctggatgcca 1453321 ttaaagaaac caaatgggtt cctgaatggg gcgagcagcg tttgcacaac atggttcggg 1453381 accgcggaga ctggtgtatt tccagacagc gtgcgtgggg tgtgccgatt ccggtatttt 1453441 acgctgaaaa cggagaaccg gttattacag atgaaaccat tgaacatgtt tctgaattgt 1453501 tcagacagca tggatcaaac atttggtttg aaaaagaagc aaaggatctt cttccggaag 1453561 gctttacgca tcctggcagc ccgaacggca catttacaaa agaacaggat atcatggatg 1453621 tttggtttga ttcaggctct tcacatcaag cagtgcttga agaacgtgat gacctcgttc 1453681 gcccggctga tctataccta gagggatctg accaatatcg cggctggttt aactcttctc 1453741 tttctacagc agtagccgta acagggaaag cgccgtataa aggtgtgctc agccatgggt 1453801 tcgcactgga tggagaagga cgtaagatga gtaaatcaat cggtaacgtt gttgttccgg 1453861 ctaaagtcat gaaacagctt ggtgccgaca tcttaagatt atgggtatct tcagtggatt 1453921 atcaggcgga cgttcgcgtg tctgacgcca ttctgaagca ggttgcggaa gtatatcgta 1453981 aaatccgcaa cacgttccgt ttccttcacg gcaacctttt cgattttgat ccaaaaacaa 1454041 atgcggtggc tgtcgaagat cttcgcgaag tggatcagta tatgctgatt aagctgaaca 1454101 agctgattga taaagtgaaa aaagcgtatg atgagtacga atttgcggtt gtgtatcaca 1454161 gcattcataa tttctgcaca atcgaattga gctcattcta ccttgatttt gcaaaagata 1454221 ttgtctacat cgagcatgcg gatcatccgg atagacgcag catgcagaca gtattctacg 1454281 aaacgcttct tgcattagtg aagctttcag cgcctatcct tccacatacg gcagacgaat 1454341 tgtggtctca tttaacattt gttgaagagc agagcgttca gttgaccgat atgccggaaa 1454401 caatcacggt tccaaacagt gaagcgactg aagaaaaatt tgaccgcttt atggctcttc 1454461 gtgatgacgt gttaaaagca ttagaaactg cgcgaaatga aaaaattatc ggtaaatctt 1454521 tggaagcaaa cctgaaattg tatccaaaca aagaaaacaa ggagctcttg gcttccataa 1454581 aagaaaacct ttctcagctg tttattgtgt ctgaactgac aatcagcgaa gaaaatgaag 1454641 cgccgaacga tgcgcaaagc tttgcgacgg gtaaaatcgc tgtcgagaaa gcggaaggcg 1454701 aaatgtgtga gagatctcgt gtgatttcaa aagatgtagg ggcaaatccg aaatatccta 1454761 cactttcatt acgcaacgct gaaatcgttg aaaaatacta tcaaaaataa tgcaaaagag 1454821 cccggcgtaa aagccgggct ttttttgtgc caagagtgac atcctttaga acgaaaggaa 1454881 aaatcttatg ggctttagat catcattcac aggcaacaat aaagatacta cgttaagagc 1454941 aggagttgtg aagaatgaat gatcaactga ccgcaattta tacggaactt cttctgatga 1455001 aagaagaatt acagtcgaga ttatttgagt attcttgctt tcaggtttct acaagcccgc 1455061 aagcagcaat caatcaaaaa caaaaagcaa ctctgatcta tcatattaaa gaagaacttc 1455121 aagacgttct ccttgcattg tccaaaatcg aaaacggcac attcggatac tgtgaagaaa 1455181 ctggggcccc cattcctctt gcaaagctgg cagtgctgcc gacggcccga acagcaaacg 1455241 attttcttta ttctgtccaa tttgagaaaa aaacgcttcc gatatggaaa tcaacggata 1455301 tcgaatatgg tcaggcactg tatgaataac agtgtctgtc cggttaatat gcctgatatt 1455361 tctttactcc agtgcttttt attgataaaa tgcataatgg attaaagtaa ccgtaaactg 1455421 gaggaacgtt tgtgctgtat tatatgattg cactacttat tattgcagcc gatcaattga 1455481 caaaatggct agttgttaag aacatggaac ttggccaaag cattccgatc attgatcagg 1455541 tattctatat cacctcccat cgcaatacgg gtgctgcatg ggggatatta gcgggtcaaa 1455601 tgtggttttt ctacctcata acaaccgctg ttattattgg tattgtttat tacatacagc 1455661 gttatacaaa gggacaaagg cttcttggcg ttgccctcgg acttatgctt ggcggtgcca 1455721 tcggcaactt tatcgatcgg gctgtcagac aggaagttgt ggattttatc catgttatta 1455781 ttgtcaatta caattacccg atatttaaca tcgcggactc ttcactatgt gtcggcgtaa 1455841 tgcttttatt tatacaaatg ctgttggaca gcgggaaaaa gaaaaaggag caatagcatg 1455901 aatcaaattg atataaccgc ttcagaagaa caaaaaagtg agcggattga taaatttttg 1455961 gcatcgactg agaatgattg gtcaagaacc caggttcagc aatgggtaaa agacggacag 1456021 gttgtcgtga acggaagcgc ggtgaaagcg aattataaaa ttcagccggg tgatcaggtg 1456081 accgtcactg tacctgaacc ggaagcgctc gacgtcctgg cagagcctat ggatctggat 1456141 atttattatg aggaccagga tgtgctggtc gtcaacaaac ctcgcggaat ggttgttcac 1456201 ccagcacccg ggcatcttac gggcacactt gtaaacggtc ttatggctca ttgcacagac 1456261 ctttccggaa taaatggtgt gatgcgcccg ggtattgttc acagaatcga taaggacacg 1456321 tccggtttat taatggtggc gaaaaatgat atggcgcacg agtcactcgt aaaccaattg 1456381 gtcaacaaaa cggtcacgcg gaaatatacg gcggttgtcc acgggcttat ttctcatgat 1456441 gacggcacaa ttgacgcgcc gatcggacgg gataaaaaag accgtcaaag catgactgtg 1456501 acacgtgatg gcaaaaacgc tgtcactcat tttcatgtgc ttgagcgttt tcaggatttt 1456561 acgttagtgg agtgccagct tgaaacaggg agaacccatc aaattcgtgt tcatatgaaa 1456621 tatatcggat tcccattagc aggcgatccg aaatacggcc caagaaaaac aatcgacttt 1456681 aatggccaag cgcttcacgc gggagtttta ggttttgacc atccacgaac aggagaatat 1456741 gtcgaatttg aagcgccgct tcccgaggat atggcagaat taatcgaaaa cctcagaaaa 1456801 aacggttgac agagggtttc ttttctgaaa taataaacga agctgaatag attctttaaa 1456861 acagtccaga gaggctgaga aggataacgg atagacggga tgcgtgtata ggcgcgcacc 1456921 ttgtcctaaa acccctctat gctctggcag gaggggtttt ttcttctata tgaactgtga 1456981 ggtgtcacac attgaatcaa aaagctgtca ttctcgacga acaggcaatt agacgggcgc 1457041 tgaccaggat tgctcacgaa atgatcgaac gcaataaagg aatgaataac tgcattcttg 1457101 tcggcattaa gacaagaggg atttacctgg caaaacgcct tgcggaacgc attgaacaga 1457161 ttgagggaaa tcctgttaca gtcggtgaaa ttgatattac tctttacaga gatgatcttt 1457221 ctaaaaaaac aagcaacgat gaaccgcttg taaaaggtgc agatattccg gtagatatta 1457281 cagatcaaaa agtcattctc gttgatgatg ttctgtatac cggaagaaca gtcagagcag 1457341 gaatggatgc gcttgttgat gtaggcagac cttcctccat tcagcttgca gtgcttgtgg 1457401 acagaggaca ccgggagctg ccgatccgag cggattatat cgggaaaaac atcccgacat 1457461 caaagtctga aaaggttatg gtacagcttg atgaggtaga ccaaaacgat ctcgtcgcca 1457521 tttatgaaaa cgaataatag atcacctttt taagggcaat ccagagaggt tgcaaagagg 1457581 tgcacaacaa aggcccaaaa agtattcggc aggtctttgt atgcctcttt gcgtaaaaaa 1457641 gcaaagaggt ttttttatac agtcattgag tcatcctaaa atgaaagtca acaatcaggg 1457701 ggaaatcatc atgagtaaga aaaaagtaaa tttaggggtc agggatgtcc cgacaccttt 1457761 ctcttgggtt tcattcagcc ttcagcattt gtttgccatg tttggctcaa ccattttggt 1457821 tccgaagctc gtcggaatga gtcctgctgt ggcgttggtg acaagcggca tcggaacact 1457881 ggcgtacctt cttattacca aaggacaaat tccggcgtat ctcggttcat ccttcgcctt 1457941 tatttctccg atcattctgg taaaagcgac cggcgggccg ggagcggcaa tggttggagc 1458001 gtttcttgca gggctggtgt acgggctgat tgccttattg attaggcagc ttggaacagg 1458061 atggctgatg aagattctcc cgcctgtagt cgtagggcct gttattatcg tcatcgggct 1458121 gggactggca agcactgcag taaacatggc gatgtatgct gatccgaacg cgagtgagtt 1458181 ggtctacagc ttaaagcact ttagtgtcgc aggagttacg ctggcaatta cgattatttg 1458241 tgcgattttc ttacgagggt ttttaagcct gattccggtt ctgatcggaa tcatcggcgg 1458301 atacctgttt gcccttactc aagggattgt caacttccag ccggtgcttg acgcgaaatg 1458361 gtttgcagtg cctgaattta tcattccgtt caaagattat tcaccgtcag ttacgctcgg 1458421 catcgcagcc gcaatggttc ctgtcgcatt tgtcacaatg tcagagcata tcggccacca 1458481 aatggtgctg agcaaggttg tcggacaaga cttcattaaa aagccaggtc ttcatcgctc 1458541 tattatgggt gacagtgtgg cgacaatcct cgcttccctg atcggcggcc ctccgacaac 1458601 gacttacgga gaaaacattg gcgtgctggc catcacaaga gtattcagcg tctttgtcat 1458661 cgggggcgcg gcagtgattg ccctttgctt cggctttatc ggcaaaattt cagcgctgat 1458721 cagttcagtg ccgtcagcgg tcatgggagg cgtctccttc ctgctgttcg gaatcattgc 1458781 ttcaagcggc ctgagaatgc tgattgacaa caaaattgat tatgaaaaca acagaaacct 1458841 cattattaca tcagttatcc ttgtcatcgg tgtaggaggc gcttttatcc aagtgtctca 1458901 gggcggattc caagtgtcag gaatggcgct tgccgcaatt gtcggtgtca tcttaaacct 1458961 gattcttccg caggcgaagg aagagcaggc agacacatct gaacaacatc atatttaaaa 1459021 ccttttaatg aaagtccaga gaggcttgga agggttatga agagaaggaa gcttcaatgc 1459081 tgccctctat ttaaccatac cccgagtcta tcttagaccg gggttttttt tcagccttaa 1459141 gttgaaaaga gaggggaaag aacatgaagc atttaacgac gatgagtgaa cttagcactg 1459201 aggaaatcaa agatttgctt caaacagcac aagagctcaa aagcggaaaa acagacaatc 1459261 agcttacagg aaagtttgca gcaaacctgt ttttcgaacc gagcacgaga acgcggttca 1459321 gctttgaggt cgcagaaaaa aagctgggca tgaatgtgct taaccttgat ggaacaagca 1459381 caagcgtgca aaaaggcgaa accttatatg acacgatccg gacgcttgaa tcaatcggtg 1459441 tggacgtctg cgtcatcagg cacagtgagg atgagtatta tgaagagctt gtcagccagg 1459501 tgaacattcc gattctgaat gcgggagacg ggtgcggcca gcatccaaca caatcactgc 1459561 ttgatttaat gacgatttat gaagagttca atacgtttaa agggcttacc gtctccattc 1459621 acggcgacat caagcatagc agagtggcaa ggtcaaatgc ggaagtgttg acaagattgg 1459681 gtgcccgggt cctattttcc ggcccttcgg aatggcagga tgaagaaaat acattcggca 1459741 cgtatgtctc aatggatgaa gcagttgagt cttccgatgt tgtcatgctg ctgcgcattc 1459801 aaaatgaacg acatcagtcc gctgtcagtc aggaaggcta tttaaacaaa tacggcttga 1459861 ccgtagaacg ggctgagcgt atgaagcggc atgcgatcat catgcatcct gctccggtaa 1459921 acagaggagt ggagattgat gacagcttag tagaaagcga aaaatcaaga atcttcaagc 1459981 aaatgaaaaa tggcgtattt atcagaatgg cagtgataca gcgtgcctta caaaccaatg 1460041 tgaaaagagg agaagcagcg tatgtcatat ctcattaaaa acggctggat actaaacgaa 1460101 aatggtgaaa aaacacaagc ggatatccga gtgactggag aaaccatcac cgcaatcggc 1460161 aagcttgatg caacggataa tgaaacggta attgatgcaa aaggtttgct cgtttcacct 1460221 gggtttgttg atctccacgt gcatttcaga gagccgggcg gagagaaaaa agaaactatt 1460281 gaaaccgggg caaaagcagc ggcgcgcggc ggctatacta cagtagcagc aatgccgaat 1460341 acgcggccgg ttcctgatac aaaggagcag atggaatggg tgcaaaacag aattaaagaa 1460401 acatcatgcg taagagttct tccatatgca tccattacga tcagacaaat cggcgatgaa 1460461 atgacaaact ttgaagcgtt aaaagaagcc ggggcatttg cttttacaga tgacggcgtt 1460521 ggtatacaga cagcaggaat gatgtatgaa gcgatgaaac gggcagccgc aattgacaaa 1460581 gcgattgttg cacattgcga ggacaactcc ttaatttacg gagggagcgt acatgagggg 1460641 acattctcca aagcgaacgg gctaaacggc attccttctg tgtgtgaatc ggttcatatt 1460701 gctcgcgatg tgctgctggc tgaggcggca aactgccatt atcatgtatg ccatatcagc 1460761 acaaaagaat ctgtcagagt tgtacgcgat gcgaaaaaag cgggaatcag agtgacagca 1460821 gaagtatcgc cgcatcattt gctgctttgt gatgaggaca tcccggggct ggacacaaac 1460881 tataaaatga atcctccgct ccgcagccca gaagacagag ctgctttaat tgaaggtctt 1460941 ttagacggaa caattgattt tatcgcaaca gaccatgcac cgcatacgga agaagagaag 1461001 aacacagaaa tgaagctggc gccattcgga attgtcggct tagaaacagc attcccgctt 1461061 ctttacacac actttgtcaa aaatggcagc tggtcactga agcagctgat tgactacatg 1461121 acaatcaagc catgcgaagc gttcggtctc ccatatggaa cattacaaac ggggcaagct 1461181 gcggacatta cgttaatcga tttagaaaaa gaagcagtta tagacaaaga gacattttta 1461241 tcaaaaggaa aaaatacacc attcaacggc atcagttgca ccggctggcc ggtcgctaca 1461301 attgcggcag ggaagcttgc ttatgaagag gggagacttg tcaaatgaag agacgattag 1461361 tactggaaaa cggagcggta ttcgagggag aagctttcgg aagcttagaa cacaacatgg 1461421 gagaagtcgt ttttaatact gggatgacag gctatcagga aattttatct gatccttctt 1461481 actgcggaca gatcgtaaca ttaacatacc cgcttatcgg aaattacggc attaaccgtg 1461541 atgattttga atccattacc ccttttgtca aagggctgat catcaaagaa ttatgtgagc 1461601 tgccttccaa ctggcgttca gcatacacct tagacgagta tttaaaaatg aaaaacattc 1461661 ccggactcca gggaattgat acaaggaagc tgacaagaat gatccgcacg gcaggcgcgc 1461721 taaaaggaac attcgcttca tctgatgaag atatcgaagc agtgctgaaa agactgaacg 1461781 aaacggaatt gccaagaaat caagtatccc aagtatcagc aaaaacagca tatccgagcc 1461841 cgggaagagg caaacgcatt gtcttggttg acttcggcat gaaacacggg attctaagag 1461901 agctgaacaa acggaaatgt gacgtcatcg ttgtgcctta caacattaca gcggaagagg 1461961 tgcttcagct gaaaccggac ggtatcatgc tttctaacgg acctggagac ccgaaggatg 1462021 tgcctgaagc gattgaaatg attaaaggtg ttcttggaaa agtgccatta ttcggaatat 1462081 gtctcggcca ccaattattc gcgctggcgt gcggggcgaa tactgaaaaa atgaaattcg 1462141 gccacagggg ctcaaaccac ccggtaaaag agctggctac aggaaaagtt gccttaacat 1462201 ctcaaaacca tggatataca gtttcgtcta tcagtaaaac agaactggaa gtgacgcata 1462261 tcgcaattaa cgacgatacg attgaagggc tgaagcataa aacattgccg gcatttacgg 1462321 ttcaatatca tcccgaagcc tcacctggtc ctgaggatgc caaccatcta tttgacagat 1462381 tcatcgaaat gatcgaaaca acagagaaag aaggggaagc ggtatgccaa aacgcgtaga 1462441 cattaacaaa attttagtaa tcggatctgg accgatcatc atcggccaag cagcagaatt 1462501 tgactatgcg ggaacacaag cctgtcttgc tttgaaagaa gaaggctatg aagtcatcct 1462561 tgtcaactca aaccctgcaa cgatcatgac agatacagaa atggctgacc gggtttacat 1462621 cgaaccgctc acacctgaat tcctgacacg aatcatcaga aaagagcgcc cggatgccat 1462681 tcttcctaca ctcggaggcc aaaccggttt gaatcttgcg gttgagcttt ctgaaagagg 1462741 cgttttggca gaatgcggcg tcgaagtgct tggcacgaaa ctgtctgcga ttcagcaagc 1462801 tgaagaccgt gacttgttca gaacattaat gaatgaactg aatgaaccgg tgcctgaaag 1462861 tgagattatc cactcccttg aagaagcaga aaaattcgtc agtcaaattg gattccctgt 1462921 cattgtccgc ccggcatata cattaggcgg aacaggcgga ggcatctgct cgaatgaaac 1462981 agagctaaaa gaaatcgttg agaacggctt gaaattaagc ccggtacacc aatgtctgct 1463041 tgaaaaaagc atcgccggct ataaagaaat cgagtatgaa gtcatgagag acagccagga 1463101 tcacgccatt gtcgtttgta acatggaaaa cattgatcca gttggaatcc atactggaga 1463161 cagtattgtt gtcgcgccga gccaaacgct cagcgatcgc gaatatcagc tcttgcggaa 1463221 tgtatcgtta aaactgattc gcgcgcttgg gatcgaaggc ggatgtaatg tccagctcgc 1463281 cttagatcca gacagcttcc aatattacat tattgaagta aatccgcgtg tcagccgttc 1463341 atctgccctt gcatcaaaag caacggggta cccgattgca aagctcgctg ctaaaattgc 1463401 agtcggactt tcattagatg aaatgatgaa cccggtgaca ggaaaaacat atgcagcatt 1463461 tgaacctgct cttgactatg tcgtatccaa aattccgcgc tggccgtttg ataagtttga 1463521 atcagcaaac agaaagcttg gcacgcaaat gaaagcgaca ggtgaggtca tggcaatcgg 1463581 ccgcacgctt gaagagtcat tgctgaaggc agtgcgatca ctggaagcgg atgtgtatca 1463641 tcttgaattg aaggacgccg ctgacatttc agatgagctt cttgaaaagc gaattaaaaa 1463701 ggccggtgat gaacgcttat tctacttagc tgaagcgtac agaagaggct acacggtaga 1463761 agacctccat gaattttccg ctatcgatgt cttcttcttg cataagctgt tcggaatcgt 1463821 acagtttgaa aaagaattga aggccaatgc gggcgataca gatgtgctga gacgggcaaa 1463881 agaactcggc ttctctgatc agtacatcag ccgtgaatgg aaaatgaaag aatctgagct 1463941 ttacagcttg agaaaacaag cggggattgc gccggtattc aaaatggtag atacatgcgc 1464001 ggcggaattt gagtcagaaa cgccatactt ctatagcaca tatgaagaag aaaatgaatc 1464061 tgtcgttaca gataagaaaa gtgtgatggt gcttggttcg ggtccgattc gaatcggtca 1464121 gggtgtcgag ttcgactatg cgacggttca ctctgtatgg gcaattaaac aagcaggcta 1464181 tgaagccatt attgtcaaca acaacccgga aaccgtttca acagacttca gcatctcaga 1464241 caagctgtat tttgaaccgc ttacgattga agatgtcatg cacatcattg acctcgaaca 1464301 gccaatgggc gttgtcgtac aatttggcgg acaaactgcg attaaccttg ctgacgagct 1464361 ttctgcacgc ggagtgaaaa tccttggaac ttcattagaa gatttagacc gtgccgaaga 1464421 ccgggataaa tttgaacaag cgcttggaga acttggtgtt cctcagccgc ttggcaaaac 1464481 agcgacatca gttaatcagg cggtaagcat cgcaagtgat atcggttatc cggtactggt 1464541 acgcccttcc tatgtacttg gcggccgggc gatggagatt gtttaccatg aagaggaact 1464601 gcttcattac atgaaaaatg cagtcaaaat caatccacag caccctgtat taattgatag 1464661 atacttgacc ggaaaagaaa ttgaagtcga tgcagtatcc gacggtgaaa cagtcgtcat 1464721 tccgggaatt atggagcaca ttgaacgtgc gggcgttcac tccggagact caatcgctgt 1464781 ttatccgcct cagtctctca cagaggacat taagaaaaaa attgaacaat acacgatcgc 1464841 attggctaaa gggctgaata ttgtcggttt gctcaatatt caattcgtct tgtcgcaagg 1464901 cgaggtgtac gtgctagaag tgaatccgag atcaagcaga accgtaccgt ttttaagcaa 1464961 aattacgggt atcccaatgg cgaatctcgc aacaaaaatc attcttggtc aaaagctggc 1465021 tgcgtttggc tatacagagg gccttcagcc tgaacagcaa ggtgtatttg taaaagcgcc 1465081 ggtcttctcc tttgccaagc tgagaagagt ggatattacg ttagggcctg aaatgaaatc 1465141 aacaggtgaa gtcatgggga aagattcgac acttgaaaag gcgctctaca aagccttgat 1465201 cgcttcaggt attcaaatcc cgaactacgg ttccgtgctt ttaacagtag ctgataagga 1465261 caaagaagaa gggcttgcca ttgctaagcg gttccacgcg atcggctaca acattttagc 1465321 gacggaagga acggcaggct acctgaaaga agcttccatt ccagcgaagg tcgtcggaaa 1465381 aatcggtcag gatggcccga acttgcttga tgtcatcaga aacggagaag cgcagtttgt 1465441 catcaatacg ctgacaaaag gaaagcagcc ggcaagagac ggttttagaa tcagacgtga 1465501 atcagtagaa aatggtgttg cctgcctaac atctttagat acggcagagg cgatattgcg 1465561 agtgctggaa agcatgacat tccgtgctga tcaaatgccg gcagtcaaca caaatcagga 1465621 ggcggcagtc actatatgaa aaaagcgtat ttgacagtat gttctaacca gcaaattgca 1465681 gaccgggtgt ttcaaatggt tctgaaaggg gagcttgtcc aagggtttac aacccctgga 1465741 cagttccttc atcttaaagt gagcgaagcg gttacgcctc ttttgagaag gccgatcagc 1465801 atcgcagacg tcaactttga aaaaaatgaa gtcaccatca tttatcgggt agatggggaa 1465861 gggacaagac tcttgtcact gaagcagcag ggagaacttg tggatgtcct cgggcctttg 1465921 ggaaatggct ttcctgttaa tgaagttcaa cccggaaaga cggctttgct ggtaggaggc 1465981 ggagtaggtg tgccgcctct ccaagagctg tcgaaacgct tgattgaaaa aggggtaaat 1466041 gtcatccacg ttttaggatt ccaatcggca aaggatgttt tttacgagga agaatgccgg 1466101 cagtacggag acacgtatgt ggcaacagct gacggaagct acggggaaac cggatttgtc 1466161 acagatgtga ttaaacggaa aaagctagag tttgatatcc tcctcagctg cgggccgaca 1466221 ccgatgctca aggcgttaaa acaggaatat gcccataaag aagtatatct gtccatggag 1466281 gaacgaatgg gctgcggaat cggcgcatgc ttcgcgtgtg tgtgccatac aaacgaaagt 1466341 gagacatcct atgtaaaagt atgtctcgac gggcctgtat ttaaagctca ggaggtggcg 1466401 ctgtaatgct agaggtgaaa ttgccgggac ttgatttgaa aaacccaatc attcctgcat 1466461 caggctgctt cggttttgga aaagaatttt cacgttttta tgatttgtct tgtcttggag 1466521 ctatcatgat taaggctacg acaaaggagc cgcgctttgg gaatccgacg ccgcgggtag 1466581 ctgagactgg tgctggaatg ctcaatgcga tcggtctcca aaatccgggg ctggatagtg 1466641 tgttgcatca tgagctgccg tggcttgagc agtttgatac accgatcatt gccaatgtcg 1466701 caggttctca agtcgatgat tatgttgaag tcgcagaaca tatcagcaaa gcgcctaatg 1466761 ttcatgctct tgaattgaat atttcctgcc cgaatgtgaa aacaggcgga atcgcttttg 1466821 gcacgaatcc tgaaatggct gccgatttga caaaagcggt gaaagaggtt tcggatgtac 1466881 ccgtttatgt gaagctatcc ccgaacgtgg ctaatatcac agaaattgca ttagcgatcg 1466941 aggaagcggg agcggacggt cttacgatga tcaacacact aatcggcatg agactcgatt 1467001 taaaaaccgg caaaccgata ttagcgaata aaacaggggg actttcgggc cctgctgtga 1467061 agccggttgc cattcgcatg gtgtatgaag tcagccagat ggtcaacatc ccgattatcg 1467121 gaatgggagg cgtgcaaacg gctgaagatg ccctggaatt tcttctcgcg ggagcaagcg 1467181 cagtcgctgt cggaacagca aactttgtga atccttttgc atgtccagag attattgaac 1467241 agctcccatc tgttttgctc caatacggct atcaatcaat tgaagaatgc atcggaagga 1467301 gctggaatca tgaaaaacaa cctgcccatc atcgcgcttg attttgcgtc agctgaagaa 1467361 acacttgcgt tcttagcgcc ttttcagcaa gaaccgttat ttgtaaaggt tgggatggag 1467421 cttttttatc aagaagggcc atctatcgtg aaacaactaa aagaaagaaa ctgcgagcta 1467481 tttttagatc taaagcttca tgacatcccg actactgtaa acaaagcgat gaagcgcctt 1467541 gccagtcttg gagtagacct cgtcaatgtt catgctgccg ggggcaaaaa aatgatgcag 1467601 gcagctctcg aaggcttaga agaaggtacg ccggctggaa aaaaacgtcc gtcacttatc 1467661 gcggtaaccc agctgacaag cacatctgaa caaatcatga aagatgaact gctgatcgaa 1467721 aagtctctga ttgatacggt tgtgcactac agcaaacagg cggaagaaag cggactggat 1467781 ggagtggtct gctctgttca tgaagcaaaa gccatttacc aagcggtgtc gccttcattt 1467841 ctgactgtca ctccggggat cagaatgtca gaggacgctg cgaatgacca agttcgcgta 1467901 gcgacgcctg ccattgcaag agagaaaggt tcatcagcga ttgtagtagg acgctcgatt 1467961 acaaaagcgg aagacccggt aaaagcctat aaggctgtca gacttgaatg ggagggaatc 1468021 aaatcttgaa acaaatcatc gcaaaacatc tattagacat ccaagctgta tttttacgcc 1468081 cgaacgagcc gttcacatgg gcaagcggca ttttatcacc gatctactgt gacaaccgcc 1468141 ttacgctatc tttcccagag gtcagaaacg atgttgcttc aggtatcagc aagcttgtta 1468201 aagagcattt tcctgaagct gaaatgattg cgggaacagc aactgccggt attcctcatg 1468261 ctgctcttgc ggcggaccat ttgaatcttc cgatgtgtta tgtgaggagc aagccgaagg 1468321 cgcacggaaa aggcaatcag attgagggag ctgtgcaaga agggcaaaaa acagtcgtca 1468381 ttgaagactt aatttccaca ggaggcagcg tgcttgaagc ttgtgcagct ttacaagcgg 1468441 ccggctgtga agtgcttggt gtcgtctcaa tctttacgta cggacttcct aaagcggagg 1468501 aagccttcgc aaaggcagaa ctgccatact actcattaac cgattatgat acgctcacag 1468561 aggtcgcgct tgaaaacgga aatattcatt cagatgatct aaaaaagctg caaacatgga 1468621 aacgaaatcc cgagtcaaaa gattggttta aaaaataaaa aataaattca aatgatgtaa 1468681 agaggcttca aagccttgct gtacttgaaa acaggctgtg aggcctgttt ttttattaat 1468741 cctataaaaa aagtcgggtt gacttatgtt agaattgtgc taaaatttac tacaaatcta 1468801 aaaacttatc aagagcggct gagggactgg acctatgaag cccggcaacc tgcatagttt 1468861 gtaaggtgct acttccagca aaatgaattc cattttgaaa gataagggct gcatgctgtt 1468921 cctgtctttc tttccgccgg attgaaagtt ttttatttta agaggtaaaa aggctatctg 1468981 tatatcagca gccgcgaatc acattacatg ggaaaagaca accggcagaa agctactgtt 1469041 tgtttgtctc cgaaaggagg aaagaagaaa tgttaacgta tgataattgg gaagaaccaa 1469101 cgattacatt tccggaagac gatccttata aaggagcgct gtcagtttta aaatgggcat 1469161 acggccatta cggcgatcag cttgtttatg cctgcagttt cggaattgag ggaatcgttc 1469221 tgattgactt aatttataaa gtgaaaaaag acgcagagat tgtgtttctt gatacaggac 1469281 ttcattttaa agaaacctat gaaacaattg aacgagtgaa agagcgttat ccgggtctta 1469341 atatcatcct gaaaaaacca gatctcaccc ttgaggaaca agccgaagaa catggtgaca 1469401 aactatggga aagagagccg aatcagtgct gctatcttag aaaggtcgtt cctttaagag 1469461 aggcgctttc aggacatcca gcctggcttt ccggcctgcg ccgtgatcaa gggccaagcc 1469521 gtgccaatac gaatttctta aacaaagatg aaaaattcaa gtcagtaaaa gtttgcccgc 1469581 ttatccattg gacttggaaa gacatttgga gatatacatc ccggaatgaa ctggactaca 1469641 atccgcttca tgaccaaggc tatccaagta ttggctgtgc gccttgcact tctcccgctt 1469701 ttacagcaga agatttgcgc tcaggcagat ggaatggtat ggcgaaaaca gaatgcggac 1469761 tgcatgaata aggagctgca aaatggaatt agccgctatt ttatttagct tgtttttcgc 1469821 gatgaatatt ggtgcaagcg gcgctgcagc ttcgatgggg gttgcttacg gctccggagc 1469881 catcaaaaag aaaacttacg ctttgatcct atgcgcagtc ggtgtctttg ccggggcggt 1469941 cattggcgga ggcgaggttg taaaaacaat cagctccggc attattcctg agcagacgat 1470001 tacactgacg attgtttgca tcattattgg agctgctgcc ctgtcgctct ttactgctaa 1470061 tctgctcggc attcctttgt cgacaagtga agtaacagtc ggcgcggttg tcggcgtggg 1470121 agtggcttat aaagtattgt ttgtgaacaa tcttctgatc attgtgtcat tttgggtttt 1470181 tgtcccgctg ttcgctttcg gcttcaccta tttcgtatct aagctgtttc gttattttaa 1470241 gattgaagta aaatcttcta aaaagcaaaa aatcctcggc attgttttgt tagttgccgg 1470301 atttttcgaa gcattctctg ccggcatgaa taacgtggcg aatgctgttg gcccgttagt 1470361 agctgccggt gtgcttgatg tcggaaaagg aaccttgtat ggaggagctt ttgttgctct 1470421 tggcgcactg ttattaggcc ggcgagtgct agaaacaaac gggaagaaaa ttacgaggtt 1470481 ctccaaaggg gaaggcattc tcttatccgg tacaggagcg ggactggtga tcatcagttc 1470541 tgtatttggg atgccggtgc ccttggcgca agtcacgtca tcgtctatta tcggaatagg 1470601 catggcgaaa aacggtccga acgtgttcca taaacaagtt gttcaaacga tgctgaaggt 1470661 atggatcgta tcgccgtttt tatctttatc gatttcttat ctgcttgtat ccttgttttt 1470721 aaaagcagat tattattcga tctttatcat ggtaagtgtg cttttagcgg cgggcggtgc 1470781 catcagcctg acaaaggcca ttcgtaaaga gagacgctca gtccacgaac aaggcggggg 1470841 aatctgatca ttaatctgag taattttata agttaactag gaggagatgg atattatgag 1470901 cttagcacca cacggaggaa cattagtaaa cagagtagat gaatcatatg atgtgagcgg 1470961 cattcaaaaa gaaattgaac ttgatttaat ttctttcgcg gatttggaat tgatcggtat 1471021 cggtgcatac agcccgattg aaggtttctt taatgaaaaa gattacgtat cagtggtcga 1471081 aaacatgcgt ctttcttccg gcgttgtctg gtctcttcca atcacgcttc cggtcgatgc 1471141 gcaaaaagca gcggaactgt cacttggtga aacggtaaag ttaacgtatg aaggagaaac 1471201 ttacggcgtt atccaaatcg aagacctgta cgtgcctgac aaacaaaaag aagctgtcaa 1471261 tgtgtacaaa acagatgaac aggagcatcc tggtgttaaa aagctgttca gccgcggcaa 1471321 tacatatgtc ggcggaccga ttacgttgat taaaaaagct tcaaaacagt tccctgaatt 1471381 tacatttgaa ccgtcagaaa cgagacgcca gtttgcggaa aaaggctggg aaaccattgt 1471441 cggtttccaa acaagaaacc ctgttcacag agcgcatgaa tacattcaaa aaacggctct 1471501 tgaaacagta gacggcttgt tcttgaatcc gttagtaggt gaaacaaaat ctgatgacat 1471561 tccagctgat gtacggatgg aaagctacca agtgcttctt gatcattatt acccgaaaga 1471621 tcgtgttttc cttggtgtct ttttagcggc gatgcgttat gcaggcccga gagaagcaat 1471681 tttccacgcg cttgtcagaa agaactacgg ctgcacacat ttcatcgtcg gccgtgatca 1471741 tgcaggtgta ggcgactatt acggaacata cgaagcacag gaactgtttg acacatttaa 1471801 acctgaagaa ctcggaatta caccgctgaa atttgagcac agcttcttct gtaaaaaatg 1471861 cggaaatatg ggaacagcaa aaacttgccc tcatggcaga gagcatcacg tcattttatc 1471921 aggcactaag gtaagaggta tgctgagaga cggtgtgctg ccgcctgctg aattcagtcg 1471981 aaaagaagta gtagaagtgt taatcaaagg gatgaagaaa aaagaagaag taggcgtatc 1472041 ttaaggagga ctggcagtga caaatcgcga tattgtatgg catgaagcct ctatcacaaa 1472101 agaagagtat cagcaaaaaa acaagcataa aagctccatt ctctggctga cagggttaag 1472161 cggctcaggc aaatcaacca ttgccaacgc cgctgcgaga gaattgtttg agcaaggcta 1472221 ccaagtcatt gtgctggacg gggataatat ccgtcacggc ctaaataggg atcttggttt 1472281 ttctgatgaa gaccgaaaag aaaacatccg ccggatcgga gaggtggcga agctttttgt 1472341 tcagcaggga accattgtga ttactgcttt tatctctcct ttccgcgagg acagacaaca 1472401 ggttcgcgag cttgtggaag cgggcgaatt taatgaagtc tacattaaat gcgaccttga 1472461 tatttgtgaa caaagagatc cgaaagggct ttacaaaaaa gcaagaaacg gcgagattcc 1472521 gttctttaca ggaattgatt ctccttatga agaaccggaa gctccagagc tcgttcttga 1472581 ttcaggacag catgaccgtg aagcgtgtaa aaatcagctg atcgagtttg ttaaacaaaa 1472641 attgagctga atatgatctg ctgcgttctt ctcagatgcc ggaatgcaag cgagaacatc 1472701 atcacagcga atcttctgga agaactcgaa tagatcgggg gaaatacgat ggggaaagta 1472761 tatattgtag gagcgggtcc cggtgaccct gatctgctga caattaaagc gctgaaagcc 1472821 attgaaaaag ctgatgtcat cttatatgac agattagtaa ataaagagat tttacaatat 1472881 gccaaagagc aagcagacct gatctactgc gggaagcttc cggattttca tacgatgaag 1472941 caggaaacca tcaatcgatt tcttgtgaag tatgcgcaaa aagggaaaat ggttgtcaga 1473001 ctgaaaggcg gagacccttt tgtgttcggg agaggagggg aagaagcgga atgcctctct 1473061 gaaaatggaa ttccgtttga aatcattccc ggcattacgt ctggaatcgc ggcagccgct 1473121 tatgccggga ttcctgttac ccatcgggat gcgggctcta acgtcgcttt tgtaacgggt 1473181 cactataaaa aagaagaaga ttttgaggaa aagtggaaag cgctggctac aggaattgat 1473241 acacttgtca tctatatggg tatcaaaaac gtgcagcaga ttgaaagaaa actccttgaa 1473301 aatggccggg acggttctac gccagcagcc tttattcatt gggggacaac ggacaagcaa 1473361 aaatctgttt tttgtacagt tgacaccctt tcagaaacgg tgataaaaga aaacattaca 1473421 aatccgagtt taattgtcat tggaaatgtt gtaaattatc actataagct ggaatggttt 1473481 gaatctgaac taaaaaaaca agatttaagc gaggcgttgt aaaaatgaaa caagcaattt 1473541 tatatgtcgg ccacggcagc cgggtcaaaa aagcgcagca agaagccgca gcctttttgg 1473601 aaggatgcaa ggcccacatc tctgtgccag tacaagaaat cagcttttta gagcttcagg 1473661 agccgacaat tgagacagga tttgaagcat gtgtgaagca aggtgccact catatcgcag 1473721 tggtgcctct gcttctttta acagctgcgc atgcaaaaca tgatattccg gaagaaattg 1473781 tccgtgttgc atctcgatat ccatcagtcc gtatttcata cggaaagccg atcgggattg 1473841 acgaagaagt agtcaaggct gtatatcacc gaatgaaaga cataggtgtt ccgtatgaaa 1473901 atgccagagt ggtgctcatc ggaaggggaa gttcagatcc agacgtcaaa agagacgtaa 1473961 ccggaattgc taatcttctt caggaaatgg ttccagtgaa ggaagtcatt ccgtgctttt 1474021 tgacagcatg cggccctaat tacaaagagg ttttttcaga acttgaaaaa gatgacggca 1474081 taacaacctt tatcgttcca tatttgcttt ttacgggtat gctgatgaat gaaatcgaac 1474141 gagaggttca gaaattaaaa gcccataatc cgaacgtcta cctctcttcc tatatcggtt 1474201 ttcatcctca tgtgaaaaac gcatttttga accgtgtgag agaaactgcg gcaaattctg 1474261 agggacaatt tgattttgat ggaggttcat atgcttccgc tgcacattag cctggaaaag 1474321 aagaaggttg tgattgcggg gggcggaagc atcgctctca gaaggctgaa aacggtgatt 1474381 tctgagggag ctgatataac gcttgtcagt ccggatgtgg aaccggaaat caagcaaatg 1474441 gcagaagagc ggcgtatcaa atgggaaaaa cggacaattg aaaaagaaga ttatctcaat 1474501 gctttcttca ttattgctgc gacggataat gcggcagtga acaaagaaat tgcccaatcc 1474561 gcttcgcctt ttcagcttgt caattgtgtc agtgacgctg agcttggcaa tgtatatatg 1474621 ccgaaaatcg taaaaagagg gcatgtcact gtgtctgttt ctacaagcgg agccagtcca 1474681 aagcacacga aagagcttgc tgaaaacgtg gataagctga ttgacggcga ttttgttgct 1474741 gaagtgaaca ggctttatca gatgagaaga aagaaataag ccagagcata caaatgctct 1474801 ggcttttctt tatgcggctc agcttttttt gagcttgatg acagtatcag catcaggcgt 1474861 gacaaagacg gtatgctggc tgtcataagt gacgaaaccg ggtttcgcgc cgtttggttt 1474921 tttgacatgc ctgatttttg tataatctac aggcactgaa cttgaatctt tagcttttga 1474981 aaaataagct gcaattgtcg cggcttccat gattgtttgc tcatcaggtt cgctgcttct 1475041 gatcacaacg tgggagccgg gaatgtcctt cgtgtgaagc cagatatcgt ctctggccgc 1475101 cactcttgtc gttaaatatt cattttgacg attgttctta cccactaaaa ttgtcagccc 1475161 tgaggtggat tcatatgttt ctaacaccgg attgtgcggt ttttgctttt tctggccttt 1475221 ttgctgctta gggcgtaaat atttgccctc aacaagctct tccctgattt cgctgatatc 1475281 ccggggagaa gcggacgaaa gctgctgaat cagctgatca aaatattcga tctcttcctg 1475341 tgccagcctg atttgctcct cgacaactgc gaccgaattt ttcgctttct gatacttcgt 1475401 gaaataggcc tgtgcgtttt cagaaggcgt tttgttcggg tttaaaggaa tcgtgattgt 1475461 cgggctttct tcatcataat aattgatgac ctcagcctgt ttatcacctt ttttcagcat 1475521 atataaatta gcggttaaaa gctctccgta aagctgaaat tccttcgcgt tttccgaata 1475581 ctccagggtt ttctctaatt ttttgatttt gttggcattc ttcttccgtt cgttcacaac 1475641 aaaacgctca agatcctgag cctgttgctt aacccggtct cgttcagctt ttccgaaata 1475701 aaaacggtcg agcagttcgc ttaatgaatc aaaacggcgc gcttcgccct ttagatgagt 1475761 cagctccagc agataaaaat attcctttcc gtttacagtc gtaatgttgg gaatgaaacg 1475821 gtgctctttc acttcggcaa acagtgccag caacgctttt ggcagtgtga ctttgttggc 1475881 aaggcctgct ctgtgaaccg cttctttggc gaaaagcgga gacacgcctg aaaagtggtc 1475941 gacaatttgt ttatcaagcc ttccttcttg aaagctgagg tgacgcaaaa tatcatcttc 1476001 tgacgcctca agaggcgata ttttgtcctg agcaggcgga agcttataat cttggccggg 1476061 cagtactgta cggtagctgt tcattgacgg tgataaatgc ttaagtccgt cgataatcac 1476121 attttctgct gcgtcagtca aaatgatatt gctgtggcgg cccataattt ctacataaag 1476181 ctttcgtacg gtttcatcgc caatttcgtt tcggcttttg atatgaaaaa tcataatgcg 1476241 gtctaagccc gcttgttcaa ttttctcaat gaatccgcct tcgatatgct ttctcagcaa 1476301 catgcaaaac attggcggtt cgcttggatt ttcataagct tgtgccgtga tatgcacccg 1476361 tgaatagctc ggatgtgccg ataataatag tttttggttt tttcccttgg cacggatgtg 1476421 gaaaatcaca tcgtgcttat atggctgatg gatttttgta attcgtccgc ccattatttt 1476481 ctcgttaagt tcgtgtgtca ttccgtatgt aaacatgcca tcaaacgaca tatgcaatac 1476541 accctctcat tcttcctgca ttcgataatt atagcatgaa atgggacgag tcagaataag 1476601 catgcttata gagtgatatc tctataagag agcaggggag tggacgagcg gaatgaagtt 1476661 tcatgaaatg ggacaaacag atttactaga ggcaaccaat acgtccatga aacaaggatt 1476721 aacagaaaaa gaggtaaaaa aacgccttga caagcatgga ccaaacgagc tgcaagaagg 1476781 gaaaaaaact tcagcgcttc tcttgttttt cgcgcagttc aaagatttta tggtgcttgt 1476841 gcttctggcg gcaacgttaa tctcaggatt tcttggtgaa tatgtagatg cggttgcgat 1476901 tattgcgatt gtgtttgtga atggcatact cggtttcttt caagaaaggc gtgctgagca 1476961 atctcttcag gctttaaaag agctttcaac accgcacgtc atggcactca gggaaggaag 1477021 ctggacaaag attccttcta aggaactggt gccgggtgat attgtgaaat ttacgagcgg 1477081 ggacagaatt ggcgcagacg ttcgaattgt tgaagcgaga agccttgaaa tagaagaatc 1477141 agcgctaacc ggggaatcaa tcccggttgt gaagcatgct gataaattga aaaaaccgga 1477201 tgtttcactc ggcgatatta ccaatatggc atttatgggt acgattgtga cccgcggcag 1477261 cggtgtcggg gttgtcgtcg ggacaggaat gaatacggct atggggaaaa ttgccgacat 1477321 gcttgaatcg gcagggacat tgtcaacccc gctgcaaaga agactggagc agctcgggaa 1477381 gattttgatt gttgttgcat tgcttctgac cgtacttgtc gttgctgtcg gtgttattca 1477441 gggtcatgat ctgtacagta tgtttttagc aggtgtctcg ttagcggtag ccgctattcc 1477501 ggaggggctg ccggcgattg tgacagtggc gctttcgctt ggtgtacaga ggatgattaa 1477561 acaaaaatcc attgttagaa agcttcctgc tgttgaaacg cttgggtgtg cgtctatcat 1477621 ttgctcagat aaaacaggga caatgaccca aaacaaaatg acagtgacgc atgtctggtc 1477681 cggagggaaa acatggagag tggcaggggc cggctatgaa ccgaaaggaa gcttcacact 1477741 aaacgaaaaa gagatcagtg tcaatgaaca taagccgctt cagcagatgc ttctgttcgg 1477801 agcgctttgt aacaactcca atattgagaa aagagacggc gaatatgtgc ttgacggaga 1477861 tccgacagag ggagcgctgc tcaccgcggc aagaaaaggc ggtttttcaa aggagtttgt 1477921 tgaatctaat tacagagtga ttgaagaatt tccgtttgat tccgcacgga aaatgatgac 1477981 tgtcatcgta gagaatcaag acagaaagcg ctatatcatt acaaaaggtg cgccggatgt 1478041 actcatgcag cgatcttccc gtatttatta tgatggctca gcggctcttt tttcaaatga 1478101 aagaaaagca gaaacagagg cggtattaag acatttggca tcacaggcgc tcagaacgat 1478161 agcggtcgcc tacaggccga taaaagcagg cgaaacaccg tcaatggagc aggcggaaaa 1478221 agatctgacc atgcttggcc tttcaggtat cattgatccc ccgcggccgg aagtcagaca 1478281 ggcgattaaa gaatgccgtg aagcgggaat taagaccgtc atgattacag gtgatcatgt 1478341 agaaaccgct aaagcgatag cgaaagactt gcgcctcctt ccgaaaagcg gcaaaatcat 1478401 ggacggcaag atgctgaatg aactttctca agaagagctt tctcatgtgg tggaggatgt 1478461 gtatgtattt gcccgcgttt cccctgaaca taaactaaaa atcgtaaaag cctatcagga 1478521 gaacgggcat attgtggcga tgacgggaga cggcgtcaat gatgctcctg ccattaaaca 1478581 ggctgatatc ggcgtctcta tgggcattac cgggacagat gtggccaaag aagcatcatc 1478641 tcttgttctc gtggatgata attttgcgac gattaaatca gcgataaaag aaggcaggaa 1478701 catctacgaa aatatcagga agtttatcag atacctgttg gcgtctaacg tcggagaaat 1478761 ccttgtcatg ctgtttgcga tgctgcttgc ccttccttta ccgctggttc cgattcagat 1478821 tttgtgggtc aacttggtga cggacggatt gccggcaatg gcgctcggca tggatcagcc 1478881 ggaaggagac gtcatgaagc gcaagccccg tcatccgaaa gaaggggtat ttgcccgcaa 1478941 gctaggatgg aaggtcgttt ccagaggatt tttaatcgga gttgccacta ttttagcgtt 1479001 tatcattgtg taccaccgca atccggaaaa cttggcttat gcccagacga tcgcgtttgc 1479061 cacattggtg ctcgctcagc ttattcacgt gtttgactgc cgcagcgaaa cttctgtttt 1479121 ctctagaaat ccgtttcaaa acctgtattt aatcggcgcg gtattgtcat ccattttgct 1479181 gatgcttgta gtaatctact atccgccgct tcagccgatt ttccatactg tagccatcac 1479241 gccgggggac tggatgctcg tcatcggtat gtccgccatc cctacttttt tgctggcggg 1479301 gtcactttta acaagaaaaa aataaattca tatgatataa tcttaggggt aatagcgtgt 1479361 ctattgccct tttattatga gaacagggaa gaattgggtg ttttaaaatg atacgaagta 1479421 tgacaggctt cggcagtgca agcaaaacac aagacgatct ctctgtaagc gttgaactta 1479481 aatctgtgaa ctacagattt aaagaagtga acgctcgttt gccaaggcct ttgctatatt 1479541 ttgaagataa gctgaaacag accattctgc agcatattca gcgcggaaga attgagcttt 1479601 tcgtatccgt tgacagcgat atgcttgttg agaaaaggct tgaaattgat tggccgctgc 1479661 tcgatgagtt tgtcgcagcc gcgagagata tgaagaagcg gtatcaattg tctgcagagc 1479721 ccgatgtaat ggatttcttt aagcttgatc atgtcgtcca ggttcatgaa gaacagacgc 1479781 aaaatgacaa gctggaggcg ttgatcatcg atgctgcaga agaagcggta aaaggtctct 1479841 gtgaaatgcg tgaaaaagag gggctgctct tagcgaaaga ctgcctgatg catattgatc 1479901 agcttgaaga gctggtgaga gaaactgaat tgctggctgc agatgtcgta tctcgttacc 1479961 gggaacggct gtatgccaga atcaaagaat ggactgaaga cgtattagac gagagccggc 1480021 ttgtaacaga atgcgctatt tttgcagacc gctctgatat cactgaagag attacaaggc 1480081 tgaagagcca cttcgcccag tttcgtgata tattagctag tggcggagct gtcgggcgca 1480141 aactcgactt tcttgttcag gagctcaatc gggaagcaaa tacgatcggc tcaaaagcaa 1480201 atgatcatca gatcacaaag cttgtcgttg aaatgaaaag ttctattgaa aaaataaaag 1480261 aacaagtgca aaatatagaa tagtgactgt gcgtattgtt tacagacggt cttactaggc 1480321 taaactagag acgtctattt tacaggggga acgtagaaga tgacgattaa actgattaat 1480381 atcggatttg gcaatatcat ctccgccaat cggatgattt cgattgtcag cccggagtct 1480441 gcgccaatca aacggatgat tcaggatgca agagaccgcg gaatgctaat tgacgctaca 1480501 tacggacgaa gaacccgtgc agttgtcgtc atggatagtg atcacattat cttatctgcc 1480561 gtccagcctg agacagttgc acacagactt tctgttaaag aagaaattat ggatgaaggg 1480621 caggggtaat tgccgcatga aagaaagagg gttattaatc gttctctcag gtccctcagg 1480681 agttggtaaa ggaacggttc gacaagcgat cttttcgcag gaagacacaa aatttgaata 1480741 ttcgatttca gtaaccacaa gaagtccaag agagggcgaa gtgaacggag tcgattattt 1480801 tttcaaaaca agagacgaat tcgagcaaat gattgcggac aacaagctgc ttgaatgggc 1480861 agagtatgtc ggcaattatt acggcacgcc agtcgattat gttgaacaga cgcttcaaga 1480921 tggaaaagac gtctttttag aaattgaagt tcaaggggct cttcaagtga gaaatgcttt 1480981 cccggaaggc ctgtttattt tccttgcgcc tccaagcctt tctgaactga aaaacagaat 1481041 cgtgacacga ggaacagaaa cagacgctct gattgaaaat cgaatgaaag ccgcaaaagc 1481101 tgagatcgaa atgatggatg cttatgacta tgtcgttgaa aacgataatg tcgaaacggc 1481161 ttgcgataaa atcaaagcaa tcgttcttgc tgaacatttg aagcgtgaac gcgttgcacc 1481221 aagatataag aaaatgctgg aggttgaata atcaatgtta gatccgtcaa ttgattcttt 1481281 aatgaataaa ttagattcaa aatatacgct ggtgactgtt tctgcgagac gtgcccgtga 1481341 aatgcaaatc aaaaaagacc aaatgattga acatacgatt tcacacaaat atgtaggcaa 1481401 agctttagaa gaaattgatg caggcctgct ttcgtttgaa aaggaagacc gcgaatagta 1481461 gcacaagtag caacctatat catgtaggtt gttatttttt tccgtgcggt tttgtaaagt 1481521 gcagaggggg agaattcatt gcttaacaat cgaaatgtgt tactttgcgt gagtggaggc 1481581 atcgctgttt ataaagcctg tgcgttaacg agcaagctgg ttcaggcagg agcaaatgtc 1481641 aaagtgatta tgactgaatc cgcttgccga ttcgtttcac cgctgacatt tcaggcattg 1481701 agccgccacg aagtctatac agatacattt aaagaacaaa atccaagcgt catttctcat 1481761 attgatgccg cagactgggc cgacttgatt atcgtagcgc cggctacggc taatgtgatt 1481821 ggaaaactgg caaacggcat cgctgatgat atgctgacga caacattgtt ggcagcaacg 1481881 gctcccgttt ggatcgcgcc ggcaatgaac gttcatatgt atgaccaccc ggcagtcaaa 1481941 cgaaacattt ctgttcttta tcaggacggt tattgtttta ttgagccaag tgagggctat 1482001 ttagcatgcg gttacgtagg aaaaggcaga ttggaagagc cggaaaacat cgtaaagctg 1482061 gccgaaaaac attttgctga agaaacatcc gctcctttag aaggcaagca tgtggtcatt 1482121 acagccggcc caacgcggga agcgattgat cctgtccggt tttttaccaa taaatcgacg 1482181 ggcaaaatgg gctacgcact ggcggaggct gctgttcagc tcggcgcacg ggtaatctta 1482241 atttctgggc ctgtttcact tgatcagcct aaaggccttg ctgagtttat ccctgttcaa 1482301 tcggctgcgg atatgcgcga agctgtgctc tctgtgtatg acgcaagcga tatagtcatt 1482361 aaaacagctg cggtagccga ttttacgccg aaaacagtat ttgaccataa aatgaaaaaa 1482421 caagacggcg gcatgacctt agaactgaaa agaacagtcg atattttgaa agaattgggc 1482481 gagaaaaaga aagagcagat tttggtcgga tttgccgccg aaacacaaga cattgaacac 1482541 tatgcacgta aaaagctcgc cgctaaaaac cttgatttga ttgtggcaaa tgatgtgaaa 1482601 gcaaatgggg ccggttttgg tgctgatacg aatatcgtga caatcttttt caaagacggg 1482661 cataaacgcg aactcccgat tatgtctaag ctcgatgttt cttttgaaat ccttcaggag 1482721 atcgcagccc tctcaaaaca aaccggagag cgctcatgaa ttttgcagaa gtcatcgttg 1482781 atgtcagcac caaaaatata gacaggcctt ttgattataa aatcccagac catctgaagg 1482841 gcatgatcaa aacggggatg cgggtcattg ttccgtttgg cccccgtaag attcaagggt 1482901 ttgtgacagc agtcaaagaa gcatctgacc tatcgggaaa atctgtcaag gaagtagagg 1482961 atttattaga tcttacacct gttctgacag aggagcttat gattctgtca tcatggctgt 1483021 cagacaaaac gctgtctttt aaaataacgg cgcttcaagc aatgctgcct gccgccttaa 1483081 aggcgaaata tgaaaaagaa ttaaaaattg cacacggagc cgatcttccg ccgcaagtgg 1483141 aacggctgtt ttctgaaaca aagacgctgc tgtattcaga tatacccgat catgagacgc 1483201 tgaaactgat tcaaaggcat gttcaaaaag gggacattga cgtgacgtat aaagtcgcgc 1483261 aaaaaaccaa taaaaaaatg gtcaggcata ttcaggcaaa tgcgagtaaa gaagagcttg 1483321 ctaagcaggc tgagggattg tcccgccaag cagcaaaaca gcaggcgatt cttcactttc 1483381 tcatctctga gccggaaggt gtgaaaattc ctgcggcgga attgtgcaaa aaaacggaca 1483441 cgagctctgc aaccatcaaa acccttatcc aaaaagggct tttgaaggaa agctatgaag 1483501 aggtttacag agatccctat caggacaaaa tgttcaaaaa aacagagccc ctgccgctga 1483561 cagacgaaca gagggctgcc ttcgagccca tacgcgagac attggacagc gatgagcata 1483621 aagtgttcct ccttcacggc gtgacaggaa gcggaaaaac cgaaatttat ctgcaatcaa 1483681 ttgaaaaagt actggcgaaa ggaaaagaag ccatcgtcct cgtaccggaa atatcgctga 1483741 cgccgcaaat ggtcaaccgc ttcaagggcc gcttcggctc ccaggtggca gtcatgcaca 1483801 gcggtttatc cacaggagaa aaatatgacg agtggcgtaa aatccaccgg aaggaagtac 1483861 ggcttgtcgt cggtgccaga tccgccattt ttgctccgtt tgaaaatctc ggaatgataa 1483921 tcatcgatga agagcacgag tcttcctata aacaggaaga aatgccgcgc tatcatgcga 1483981 aagaggtggc aatcaagcgg gctgagcatc acagctgccc ggttgtatta gggagtgcta 1484041 cgccgacatt agaatcatat gctagagcgc aaaagggcgt atacgagctt ctttcactga 1484101 agcaccgtgt taaccatcgg gtgatgcccg aggtttcgct tgtcgatatg agagaggagc 1484161 ttagaaacgg caatcgctcg atgttttcag ttgaattgat ggaaaagctt gaagaaacga 1484221 ttgccaaggg tgagcaggcg gtgctgtttt taaataagag gggctactct tcctttgtga 1484281 tgtgcaggga ttgcggctat gtcccgcaat gcccgcactg cgacatttcc atgacgtatc 1484341 atcgttacgg ccaaaggctg aaatgccatt attgcggaca tgaagagcct gttccgcaca 1484401 cttgtcctga atgcgcaagc gagcatatcc gctttttcgg aacgggaaca cagcgagtgg 1484461 aggaagagct gacaaaagtg ctgccaagtg cgagagtgat tcggatggat gttgacacga 1484521 catcacggaa aggcgcccat gaaaaattac tgtcagcttt cggagaagga aaagcggata 1484581 ttcttctcgg aacgcaaatg atcgcgaaag ggcttgattt tccgaatgtc acgcttgtcg 1484641 gagtgttaag tgctgataca acacttcata ttcctgattt cagatcggct gaaaaaacat 1484701 ttcagctgtt aacgcaagtc agcggccggg caggcaggca tgaaaagccc ggccatgtca 1484761 tcattcaaac gtatacaccg tctcattaca gtatccagct gacgaaaaca cacgattatg 1484821 aaacgttcta tcagcatgaa atggcgcaca ggagagagca atcctatccg ccatactact 1484881 atttggctct tgtgactgtt tctcatgagg aagtggcgaa agcagcggtt acagctgaaa 1484941 aaatcgctca ttttttgaaa gcaaactgcg gagctgacac gaaaattctc ggaccaagcg 1485001 cgtcgccgat agccaggatc aaagatagat atcgctatca atgcgtgata aaatacaaac 1485061 aggaaaccca gttatccgct ttattgaaga agatactgga acattataaa cgcgaaattg 1485121 aacaaaaaca tgtaatgatt tcaattgata tgaatcctta tatgatgatg taagatctca 1485181 cgtcttggag ggtaacaaat tggcagtaaa aaaggtcgtc acacatcctg cggaggtttt 1485241 ggaaacacct gcggaaaccg tgactgtttt tgataaaaag ctaaaaaaac tgcttgatga 1485301 tatgtacgac accatgcttg aaatggatgg tgtcggactg gcagcgccgc aaatcggcat 1485361 tttaaaaaga gcggccgtcg tagaaatcgg ggatgacaga gggagaattg atctcgttaa 1485421 tcctgaaatt ttagaaaaaa gcggcgagca aaccggaatt gaaggatgct tgagctttcc 1485481 taacgtctat ggtgatgtca cacgtgccga ttatgtcaaa gtgcgtgcgt ttaaccgtca 1485541 gggaaaaccg ttcattctgg aagcgcgagg ctttttagca agagccgtgc agcatgaaat 1485601 ggaccactta gacggtgtgc tgtttacatc taaaataagt aaatactata cagaagatga 1485661 actagcggat atggaaggat gatttgatga cgagaatcgt atttatggga acgccggatt 1485721 tttcagttcc tgttttaaga accctgatag aggacggata tgaagtagtg ggggtcgtca 1485781 cacagccgga ccgtccgaag ggcagaaaaa aagtactgac acctcctccg gtaaaggaag 1485841 aggcattgcg ccacggcatc ccggttcttc agccggaaaa agtcagattg acagaagaaa 1485901 ttgaaaaagt gctggcatta aagcctgacc tgattgtaac ggcggcattc ggacaaattt 1485961 tgcctaaaga gcttctcgac agtccaaaat acggctgcat taacgttcac gcatcccttt 1486021 tgccggaact gcgcggcggt gctccgatcc attattccat tctgcaggga aagaagaaaa 1486081 ccgggattac cattatgtat atggtagaaa aattggatgc gggcgatatg atctcaaaag 1486141 tggaagtgga cattgaagaa accgacaatg tcggaacact gcacgataaa ttaagcgttg 1486201 ctggcgcgaa gctattgtct gaaacggttc caaacgttat tgccggcagc atatcacctg 1486261 aaaagcagga tgaagagaaa gcgacgtacg cgcctaacat taaaagagag caagagctgc 1486321 tcgactggtc cagaacgggc gaagagcttt acaaccagat ccgcggctta aatccatggc 1486381 ctgttgctta tacgactcta aacggacaaa acttgaaaat atgggcgtcg aaaaaaatag 1486441 cggcaccaac aacagctgag cccggcacag tcgttgcagt tgaaaaggaa ggaattatcg 1486501 ttgccacagg taacgagacg gctctgttat taaccgaact ccagccggca ggcaaaaaac 1486561 gaatgaaagg cgaagacttt gtgcgaggcg ctcatgttga agccggtgat gtgttaggag 1486621 taaacaatga aaaaaactag tgttcgtgac atcgcccttg aggcgctgat caaattagaa 1486681 caaaaccagg catacagcaa cctgctgctg aaatcggtca ttaaatcaaa tgaactgagt 1486741 gatcagaaca gagggctttt gactgaactt gtctatggta cattacaaaa taagatcgcg 1486801 cttgattata tgcttaaacc gtttatcaat aagcctcaaa aggtaaagcc gtgggtgatt 1486861 cagcttcttc gcctatcctt atatcaaatg gagtatttgg agaagattcc agacagggca 1486921 gccattcatg aagcggttga gattgctaaa atccgcggac acaaaggcat tgcttcattt 1486981 gtcaacggcg tgctccgttc tattcagcgc gaaggtgttc catcctttga cgcgatcgaa 1487041 gatcctgtcc gccggctggc gacagaaaca agccatccgg aatggcttgt gaaagagtgg 1487101 gcggatgcgt atggatttga agctgcggaa aagatttgcc gcatccatct cattccgccg 1487161 aaacagacgc tgcgtgtcaa tcaaatgaaa gcagacagag ctgagctgct tgaccaaatg 1487221 gctgctgagg gaatcgaagt tgaaaaaggc gacctcgctg aagatgctgt gaagctctta 1487281 aagggaacaa ttgccggaac tcatttcttc caaaacggcg aagtttctat ccaggatgag 1487341 agctccatgc tcgtcgcccg cgcccttgat cctaagtcag atgaaacagt gcttgacgcg 1487401 tgtgcggcgc ctggcggaaa gtcggctcat atcgcagaat taatgaagaa caaggggagc 1487461 gttacgtcgc ttgatcttca caaacataaa gtgaagctga tcaaagaagc ggcagatcgg 1487521 cttggcctga caatcattca tgcggaaaca atggatgcta gaaaagcggg ggaaacgttt 1487581 gaaaacgaac agtttgaccg aatattggtc gatgccccgt gctcaggttt cggtgttatc 1487641 agaagaaagc cggacatgaa atacacgaaa aaacctgacg acagcgcccg tctagctgaa 1487701 atccagctgt cgatcttgag ggaaatcgca ccattagtaa aaaaaggtgg cactcttgtc 1487761 tacagtacgt gtacaatgga ccggacagaa aatgatgaag taatacatgc gtttatacaa 1487821 gaacatcctg attttgaacc cgatttgtct cttgaaaagc ggctgcctga aaaggtgaga 1487881 ccctttgttc gggatggaag gcttcaaatc cttcctcatt atttcggaac agatggtttc 1487941 tttatttgca gcatgagaaa gaagggataa gcaatggcag aacttaataa aacaaaagta 1488001 agaaaagaat tgcggacaga gcgtccgtct atttattctt ttgaattaga tgaaatcaaa 1488061 caatggctga cagacaatgg agagaaaccg ttccgtgcag cccagatctt tgaatggcta 1488121 tatgaaaaac gcgtatcttc ttttgaagat atgacaaacc tctcaaagga tctgcgtgag 1488181 aaattaaaca ctcgctttgt gttaacaacg ctgaaaacgg ctgttaaaca aacctctcaa 1488241 gacggtacga tgaagttttt gtttgagctt catgacggtt ataccatcga aaccgtttta 1488301 atgagacacg agtatggcaa ttctgtatgt gtaacgacac aagtcggctg ccgtattggc 1488361 tgcacattct gcgcgtcaac gcttggaggc ttaaaacgaa accttgaagc aggggaaatt 1488421 gtcgctcaag tagtcaaagt gcaaaaagct cttgatgaaa cggatgaacg cgtcagctct 1488481 gtcgtgatca tgggaatcgg cgaacctttt gataacttta acgaaatgct cgctttcttg 1488541 aaaatcatta accatgacaa gggcctgaat atcggtgctc gccatattac ggtctctacg 1488601 agtggaatca tcccgaaaat ttacgaattt gctgatcagc aaatgcagat taactttgca 1488661 atttctctgc acgcgccgaa cacagaaatc agaagccgtt tgatgccgat taacagagca 1488721 tataaactgc ctgatctaat ggaagccgtt aaatattata ttaataaaac aggacgccgt 1488781 atcagctttg aatacgggct gttcggaggc gtaaacgacc aggtggaaca cgccgaagag 1488841 cttgccgact tgctggaagg agtcaaatgc cacgtgaact tgattccggt aaactacgtg 1488901 cctgaacggg actatgtgcg cacaccgcgt gatcagattt ttgcttttga aaaaacgctg 1488961 aaatcccgcg gagtaaatgt cacaatccga agagagcaag gacatgacat tgacgcagcc 1489021 tgcggtcagc ttcgcgcgaa ggagcgtcaa gacgagacga ggtgatgagg gttgttaaca 1489081 gccttaaaaa cagatacagg aaaaatccgc cagcataatg aagatgatgc ggggatattc 1489141 aaggggaaag atgaatttat attagcggtt gtcgctgatg gcatgggcgg ccatcttgct 1489201 ggagatgttg cgagcaagat ggctgtgaaa gccatggggg agaaatggaa tgaagcagag 1489261 acgattccaa ctgcgccctc ggaatgtgaa aaatggctca ttgaacagat tctatcggta 1489321 aacagcaaaa tatacgatca cgctcaagcc cacgaagaat gccaaggcat ggggacgacg 1489381 attgtatgtg cactttttac ggggaaaacg gtttctgttg cccatatcgg agacagcaga 1489441 tgctatttgc ttcaggacga tgatttcgtt caagtgacag aagaccattc gcttgtaaat 1489501 gaactggttc gcactggaga gatttccaga gaagacgctg aacatcatcc gcgaaaaaat 1489561 gtgttgacga aggcgcttgg aacagaccag ttagtcagta ttgacacccg ttcctttgat 1489621 atagaacccg gagacaaact gcttctatgt tctgacggac tgacaaataa agtggaaggc 1489681 actgagttaa aagacatcct gcaaagcgat tcagctcctc aggaaaaagt aaacctgctt 1489741 gtggacaaag ccaatcagaa tggcggagaa gacaacatta cagcagtttt gcttgagctt 1489801 gctttacaag ttgaagaggg tgaagatcag tgctaatcgg caagcggatc agcgggcgtt 1489861 accaaattct ccgcgtcata ggcggcgggg gaatggccaa cgtgtattta gctgaggata 1489921 tcattctaga ccgtgaagtc gcaattaaaa tcctgcggtt tgactatgca aatgacaatg 1489981 aatttatcag acgtttccgc agagaagccc aatccgcatc aagcctcgat cacccgaata 1490041 ttgtcagcat ttatgatttg ggcgaggaag atgatattta ttatattgtc atggaatacg 1490101 ttgaaggcat gacgcttaaa gaatacataa cagcaaatgg gccgcttcac cctaaagaag 1490161 cgctgaacat catggagcaa attgtctcag ccatcgctca tgcccatcaa aaccagattg 1490221 ttcacagaga catcaagccg cataacattt tgattgatca tatgggaaat atcaaagtaa 1490281 cggattttgg aattgcgacg gcactaagtt cgaccacaat cacccatacc aattcagttc 1490341 tgggctcggt ccattactta tcacctgaac aggcccgggg cggcttagcc acaaaaaaat 1490401 cggatattta tgcgcttgga atcgttctat ttgagctttt aaccggccgt attccgtttg 1490461 atggagagtc agcagtcagc atcgccttga agcatcttca agcggaaact ccttcggcaa 1490521 aaaggtggaa tccatcggtc ccccaaagcg ttgaaaacat catactcaag gcaactgcca 1490581 aagatccttt tcatcgctac gaaacggctg aagacatgga agcagacata aaaacagctt 1490641 ttgatgccga cagactcaat gaaaagagat ttacgattca agaagatgaa gaaatgacaa 1490701 aagcgatacc tatcattaaa gatgaagaac ttgctaaagc tgctggcgaa aaagaagctg 1490761 aagtgacaac cgcacaagaa aacaaaacaa agaagaacgg caaaagaaaa aagtggccgt 1490821 gggttttgct cacgatatgc ctcgttttta tcacagctgg aattcttgct gtcactgttt 1490881 ttccgtcgct tttcatgcct aaggatgtca aaatacctga tgtctccgga atggaatacg 1490941 aaaaagccgc agggctcttg gaaaaagaag gtttacaggt tgattccgag gtgttggaaa 1491001 tctcagatga aaaaattgaa gagggcctga tggtaaaaac ggatcctaaa gcggatacca 1491061 cagtcaaaga aggcgccacg gtcacccttt ataagagcac cggaaaagca aaaacggaga 1491121 tcggtgatgt gacaggccaa acggtcgacc aagcaaaaaa agcgttgaag gaccaagggt 1491181 ttaatcatgt aacagtaaat gaagtgaatg acgagaaaaa tgcgggcact gtcattgacc 1491241 aaaatccttc agcagggact gagctggtcc cgagtgaaga tcaagtcaaa cttacagtca 1491301 gtatcggacc cgaagacatt acgcttagag acttgaaaac ctacagtaaa gaagcagcgt 1491361 ctggatatct ggaagacaac ggattgaagc ttgtagaaaa agaagcatac tcagatgatg 1491421 ttccagaagg acaggttgtc aaacaaaaac cagcagcagg tacggcagta aagccgggaa 1491481 acgaagttga agtgacattc tctctcggac cagagaaaaa acctgcgaaa acagtgaaag 1491541 aaaaggtcaa gatcccctac gaaccagaaa atgaagggga cgagcttcaa gtgcaaatcg 1491601 cggttgacga tgcggatcac agcatctctg acacttacga agaatttaag ataaaagagc 1491661 cgactgaacg aacgatcgaa ctaaagattg aaccaggcca aaaagggtac tatcaagtaa 1491721 tggtaaacaa taaagttgtc agctacaaaa ccattgagta tccgaaagat gaataacaag 1491781 gagggaaaat atgcctgagg gcaaaattat taaggcgcta agcggctttt actatgtact 1491841 ggatgaatca gaggattcag ataaagtaat acaatgcaga ggaagaggca ttttcagaaa 1491901 aaacaaaatt acccctcttg tcggtgatta cgttgtgtat caagctgaaa atgacaaaga 1491961 aggatatcta atggaaatta aagaaagaac caacgagctt atcaggccgc caatttgcaa 1492021 cgttgatcaa gcggtccttg ttttctcagc ggttcagcct tctttcagca cggcattgct 1492081 cgaccgcttc ctggttctcg ttgaggccaa tgatattcag ccgattatat gcattactaa 1492141 aatggatctg attgaagatc aagatacaga agatacgata caagcctatg cagaagacta 1492201 tcggaatatt ggttatgacg tataccttac ctcctctaag gaccaagata gtttagcgga 1492261 catcatcccg cattttcagg ataaaacaac ggtatttgcc ggtcagtccg gtgttgggaa 1492321 atcctcgctt ctcaacgcga tcagtccgga gctcggatta agaacaaacg agatttccga 1492381 gcatttgggc cgcgggaaac acacaacccg ccacgtggag ctgattcaca cgtccggagg 1492441 tttggttgca gatacaccgg gattcagctc gcttgaattt acagacattg aggaagaaga 1492501 gctgggctat accttccctg atatcagaga aaaaagctct tcatgcaaat ttagaggctg 1492561 tttacatctg aaagagccga aatgtgcggt gaaacaagct gttgaagacg gggaattaaa 1492621 gcagtatcgc tatgaccatt atgttgaatt tatgacggag attaaagaca gaaagccgag 1492681 gtattagcat aatgataaag gttgcaccat ctattctttc cgctgatttt gccgctttag 1492741 gcaatgagat taaagatgta gaaaaaggcg gagccgattg tattcatatt gatgttatgg 1492801 acggccattt tgtcccgaat atcacaatcg gtccgctgat tgtagaagcg gtccggccgg 1492861 taacggatct gccgcttgat gtccatttaa tgatagaaga gccggatcgt tatatcccgg 1492921 cttttgcgaa agcaggcgca gatatcctgt ctgtgcatgc tgaggcatgt ccgcacctgc 1492981 accgtaccat ccagctcatt aaagagcaag gagtgaaggc cggagtagtt ctaaacccgc 1493041 atacccctgt acaagtcatc gaacatgttt tcgacgatct tgatcttgtt cttttaatga 1493101 cggtgaaccc gggcttcggc gggcagaaat ttattcattc agtccttcct aaaataaaag 1493161 aggttaagcg aatggcggat gaaaaaggaa aaaaagatct gttaattgaa gtagacggcg 1493221 gcgtcaacaa agaaaccgct ccgctcgtca ttgaagcggg cgcaaattta ctcgttgccg 1493281 gttcagctgt ttatggccag tctgaccgca aaaaagcaat ttctgaaatc agaggaagta 1493341 aataagcagc tttagaaaag agctgggcat acaatagcct aagctctttt tcctgtatgc 1493401 agagaaagga atcagagatg aaaacaatta atatcgttgc gggaggcccg aaaaatctca 1493461 ttcccgatct aaccggctat acggatgaac acacgctttg gatcggtgtt gacaaaggca 1493521 ccgtcactct cttagatgcc gggatcattc ctgttgaagc cttcggagat tttgacagca 1493581 taacggagca agaacgccgg cgaatagaaa aagccgctcc cgcccttcat gtgtatcaag 1493641 cagaaaaaga tcaaacagat ttagacctcg cccttgattg ggcgctggaa aagcagccgg 1493701 atattattca gattttcggc attacaggcg gcagagctga tcatttttta ggaaacattc 1493761 agcttctgta taaaggtgta aaaacgaaca taaaaattag gctgatagac aaacaaaatc 1493821 atattcaaat gttccctcct ggtgaatatg atattgagaa ggatgaaaat aagcgatata 1493881 tctccttcat accgttttcc gaagacatac atgagctgac cctgaccggt tttaaatatc 1493941 ctctaaataa ttgtcatatt acgctcggtt caacactatg tattagtaac gaactcattc 1494001 attcacgagg tactttttcg tttgcaaaag gcatattaat aatgataaga agcacggatt 1494061 aagcatgtgc tttcattcaa ttgctgaaaa caatgaacaa ggcggttacg ggacgttata 1494121 ggaggggaca aaaatgaaat tttacaccat taaattgccg aagtttttag gaggaattgt 1494181 ccgggcgatg ctgggctcat ttagaaaaga ttaatgccca ggggttcaaa gccctctttc 1494241 accacataaa aacgcctgcc acatatcggg gcaggcgttc attttgttat acacgctcaa 1494301 ctttaccgga tttcaaagct cgagcagata catatacttt tttaggtttt ccgttcacaa 1494361 ggatacgaac cttttgaaga ttcgcgcccc aagtgcgctt agaagcgttc attgcgtgag 1494421 aacggttatt cccagctgtt gtttttttac ctgtgataac gcatttacgt gccatttgtt 1494481 tccctcctca cttgcacaaa acatctactt tttaacattc atataatctt agatgctttc 1494541 gatatggata ctttaaataa tttaccacag ctaaaaaacg tttgcaacta ttgtttcatc 1494601 atctttcaag aaaattcact tgacatcttg cggaaacagc agcgctatag tatatgtaga 1494661 ggtacggcca gcgattattg cctggtcttt tcataatgga aaccatatag tagaatagct 1494721 gtaactctat gcattcgaag gaggaactag tgtgtccatt gaattaagaa cgaagtacgg 1494781 acagattgat atatctaatg aagtcatcgc gatggttgca ggaggcgcgg cggttgactg 1494841 ttacggcatt gtcggcatgg cctctaaaaa ccagattaaa gacggactga ctgaaatcct 1494901 tcggaaagag aatttcagca ggggtgtcca agttcgccaa gaaggagaac agatacatat 1494961 cgacatgtat atcattgtca gctacggcac gaaaatttct gaagtggcac ataatgtcca 1495021 aacaaaagta aagtacacag taaatcaaac catcggactg gcagtggatt ctgtcaatat 1495081 ttatgtccaa ggcgtacgag tgacgaaccc gtagttagga ggagtaggat tgtctatcag 1495141 aacattagac ggcagaacct ttgccgagat gattcttgcg ggagcgcaga atctgtctca 1495201 aaacgccagt gcagttgatg cactgaacgt gttcccggtg ccggacggtg atacgggaac 1495261 aaatatgaac ctgtcgatga cttccggagc aagagaagtt gaacaaatgg atacggatga 1495321 tatcgggaag gtgggctccg cgttatctaa agggctgctc atgggagcac gcggaaattc 1495381 aggagttatc ctatcccaat tgttccgcgg atttagcaaa aacattgaaa cgaaaaaaga 1495441 aattaatgca cttgagtttg ccgctgcgct gcaagcaggt gtagacatgg cgtataaagc 1495501 tgtcatgaaa cctgtagagg gcaccatttt aacagttgca aaagacgctg caaaaaaagc 1495561 aatgatctta gcagaaaaag aaaccgatat cactgcgctg atgactgcag tgacagaaga 1495621 agcagaggcg tctttaaacc gcacccctga attgctacct gtcctaaagg aagtaggagt 1495681 tgtcgatagc gggggcaaag gcctgctctg tgtgtatgaa ggtttccttg cttcattaaa 1495741 aggtgaaact gtacctcaga aagcagttct tccgtcactt gacgacatgg tcagcgcaga 1495801 gcatcacaag agcgcgcaaa gcatgatgaa taccgaagat attgaatttg gattctgtac 1495861 cgaagtgatg gttaggcttg atcagacaaa aagagagttc gacgaaggca cgttcaggca 1495921 agacctcagc cagttcggag attctctgct tgtgattgcg gatgaatcgc tggcgaaggt 1495981 tcatattcat gctgaagagc cgggaaacgt gttaaactac gcccagcatt acggtgaatt 1496041 gatcaaaata aaaatagaaa atatgagaga acagcatacc tctatcatca gtcaagaaag 1496101 caaacctgca gacaacgaaa caccgccggc aaaacagccg tatggcattg tgactgtagc 1496161 gatgggagaa ggaattgcag acctatttaa aagcattggc gcttctgttg tgattgaagg 1496221 cggccagacc atgaacccaa gcactgagga tattgttgat gccgtgaagt ctgtaaatgc 1496281 agatacggta tttatcctgc ctaacaactc caacattatc atggctgcta accaagcggc 1496341 cagcgtagtg gatgaacagg tttttgtcat tcctgctaaa acggttccgc aagggatgtc 1496401 agctctgctg gcttttaacc cggatcaaga agctgaagcg aacgaggcca atatgctaag 1496461 cgccattcag caagtaaaaa gcggacaggt gacgttctca gtcagagata ctcatattga 1496521 cggtaaagac attaaaaaag gcgactttat gggcattctg aatggaacga ttatcggcac 1496581 ttctgaaaat cagctgtcag ccgcgaaaat gctgctgtca gaaatgatcg gagaagatga 1496641 tgaaatcgtg accattctat atggtgagga tgcgtctcag gaagaagctg agcagcttga 1496701 agcgtttctc agtgaaaagt acgaggagat tgaggttgag atccacaatg ggaaacagcc 1496761 tctgtattcg tatatagttt cagcagaata gaagggcaat ttgcccttct attcttatgt 1496821 ctgcttttaa gtgcggcagc gctgtaacgc gcccgcttgc cattttatat ctgatcaatt 1496881 agtctagaag caaagcgcta ataagctctg gttcataagg aggaatagca tgaaatacag 1496941 aagcgttttt gatattatcg gcccggttat gatcggtccg tccagctctc atacagcggg 1497001 agctgctaga atcgggagag tggccagaag tttatttggc agagagcctg agcgcatcat 1497061 tgtatctttt tacggctcgt ttgcggaaac gtataagggc cacggcacag atgtcgcgat 1497121 tatcggcgga ttgcttgatt ttgatacatt cgatgaacgg attaaaaccg ctatacaaat 1497181 tgcagaagct aaaggaattg atatagagtt tcgggtagaa gacgcagtcc cggtccaccc 1497241 gaacacagca aaaatcacca tttctgatga aaagggtgag ctggaactga cgggtatttc 1497301 gattggcgga ggaaagattg aaatcacaga attgaatggt tttgagctcc ggctgtcagg 1497361 aaatcatccg gccatattag ttgttcataa tgacaagttt ggcacaattg ccggtgttgc 1497421 caatgttctg gcgaaatttt caatcaacgt aggacatatg gaagtagccc ggaaagatat 1497481 cggccagctt gcgctgatga caatagaggt cgatcaaaat attgacgacc acattctcga 1497541 cgagctgtcg aagctgccga atattattca agtgacaaag attgctgact agcgaaaagg 1497601 gtcaggagga gccagttatg tttcgtaatg taaaagaatt aattgagatt actaaagaaa 1497661 aacaaatatt gatctctgat gtgatgatag ctcaagagat ggaagtaaca gaaaaaacaa 1497721 aagaggacat ttttcagcag atggatcata acctgtctgt tatggaagcg gcggttcaga 1497781 aaggactcga gggagttacg agccaaacgg gcttaacagg cggagatgcc gttaaattgc 1497841 aggcctatat tcgatcagga aaaagcctgt ctggcccgct gattttagat gctgtatcga 1497901 aagccgttgc aacaaatgaa gtaaatgcag ccatgggaac catctgtgcg acaccgactg 1497961 caggttctgc cggtgtggtg cccggtacgt tatttgctgt aaaagaaaag ctgaatccaa 1498021 caagagaaca aatgatccgc tttttgttta cagccggggc tttcggattt gtcgtggcca 1498081 ataacgcaag catttccggc gccgccggag gatgtcaggc agaggttgga tcagcttcag 1498141 gcatggcggc tgcggctatt gttgaaatgg caggaggaac acccgaacaa agcgcggaag 1498201 ccatggccat tacattaaaa aatatgctag gcctcgtgtg cgaccctgtt gcagggcttg 1498261 ttgaggtgcc ttgcgtgaaa cggaatgcga tgggcgcgtc aaatgcgatg attgctgctg 1498321 atatggcatt ggcgggcatt acaagccgta ttccatgtga tgaggttatc gatgccatgt 1498381 ataaaatagg ccaaacgatg ccaactgcac ttagagaaac aggccagggc ggtttagcgg 1498441 caacaccgac aggaagagaa ttagagaaaa aaattttcgg aggagcgcta ggttcacgtg 1498501 aaacaacatc agcaaactag tatagctaac attaagggta ttgggccgga aacagaaaaa 1498561 acattgaatg aactcggtat ttatgacatt tctgatcttc tgaattattt cccttatcgc 1498621 tatgatgact acgagctgag ggatttagaa gaagtaaagc atgatgaaag agtcacagtc 1498681 gaagggaagg ttcattcaga gccttctctt acctattacg gaaaaaaacg aaacaggctg 1498741 acattcaggc ttctggtcgg ccactattta atcacagccg tatgttttaa ccggccttat 1498801 ttgaagaaga agctttcgct cggctctgtg gtgacggttt caggtaaatg ggacaagcac 1498861 cgccaaacca tctctgttca ggagttgaaa aacgggccgc atcaagaaga caaaagcatt 1498921 gaaccagtgt attctgtgaa agaaaatgtt accgtcaaaa tgatgaggcg ctttattcag 1498981 caggcgctga cccaatatgc agactcactt cctgatcctc ttccggaaaa gctaagaaaa 1499041 agctataaac tgcctgacta ttatcaagcg ttaaaagcaa tgcaccagcc tgaaacaagg 1499101 gaagcattaa agcttgccag acggcggttt gtttatgaag aatttttgtt gtttcagttg 1499161 aaaatgcagg cgttccgaaa ggcggaaaga gagcagacac aagggatacg gcagcgtttt 1499221 tcaaacgaag aactcatgag atttatcaaa agcctcccgt ttcccctcac aaacgcccag 1499281 tcacgcgttc ttcgcgaaat aacagcagac atgtcttctc catacagaat gaaccgtctt 1499341 cttcaagggg acgttggatc aggaaaaacg gcagtcgccg ccattgcact gtatgccgcg 1499401 atcctatccg gataccaagg agcgctcatg gtgccgacag aaattctggc cgagcagcat 1499461 gctgattcgc tcgtttcgct atttgaaaaa tgggacgtca gcgttgctct tttgacaagc 1499521 tctgttaaag gaaagcggcg aaaagaactg cttgagcgtc ttgcggcggg tgagattgat 1499581 attcttgtag gaacccatgc tttaatccaa gacgaggtgg agtttaaggc gttgagtctc 1499641 gttattactg atgaacagca cagatttgga gttgagcagc gcaaaaagct tcggaacaaa 1499701 gggcaggatc ccgatgttct ctttatgaca gccactccaa tcccaagaac attagcgatc 1499761 acagtattcg gtgaaatgga tgtatctgtc attgatgaga tgccggctgg acgaaagcga 1499821 attgaaacct attgggtaaa acatgacatg cttgatcgta ttttggcatt tgtcgaaaaa 1499881 gaattaaagc aaggcaggca ggcttatatc atctgtccgc tgattgaaga atcagataag 1499941 cttgatgtgc aaaacgccat tgacgtgtac aatatgcttt ctgatatttt tcggggaaaa 1500001 tggaatgtcg gccttatgca tggaaagctg cattccgatg aaaaagatca ggtcatgaga 1500061 gaattcagcg caaatcactg tcaaattctc gtatcaacca ctgttgtgga ggttggcgta 1500121 aatgttccga atgcaacaat tatggtgatt tatgacgccg accgtttcgg actatcacag 1500181 cttcaccagc tgcgcggccg tgttggacgg ggtgagcatc aatctttctg tattctgatg 1500241 gctgatccaa aatcagaaac agggaaagaa cggatgagga tcatgtcgga gaccaatgac 1500301 ggtttcgagc tgtctgaaaa ggatctggaa ctgagaggtc ccggtgattt cttcgggaaa 1500361 aaacaaagcg gaatgccgga atttaaagtg gcggacatgg ttcatgatta cagagcgctt 1500421 gaaacggcaa ggcaggatgc tgcgaatctt gtggcttctg acgcgttctg gaaggagccg 1500481 gaatacgctg tgttaagaga tgaattgctg aagagcggag taatggacgg ggaaaaatta 1500541 agctgagtat cagaagtttt tggtgttcag ccagaaacaa tcgttgcatt ccaatctatg 1500601 aaattatata ctactattag tacctagtct taattgtccg gatggtgttt agatatgaga 1500661 agaaataaga gagaacgcca ggaattactt cagcagacga ttcaagcaac cccctttatt 1500721 acagatgaag aactagcggg taaattcggg gtgagcatcc agacgatacg tttggaccgc 1500781 ttagagcttt ccatacctga actgagagaa agaattaaga acgtggcaga gaaaacactt 1500841 gaggacgaag tgaagtccct gtcacttgat gaagttatcg gagaaattat tgaccttgag 1500901 ctggatgatc aggcgatatc cattttagaa ataaaacagg agcacgtgtt cagccggaat 1500961 cagattgcga gaggacacca tttatttgca caggcgaatt ctttggccgt tgcagtcatt 1501021 gatgacgagc tggcgctgac tgcaagtgca gacatccgct ttacaagaca ggtaaagcag 1501081 ggtgaacgtg tcgtagcaaa agcgaaagtg acggctgtcg aaaaagaaaa aggaagaacg 1501141 gttgtcgaag tgaacagcta cgttggcgaa gaaattgttt tttctggacg ctttgacatg 1501201 tatcgttcaa aacattcata aaggtggagc atgcatgaga atagctgtag atgcaatggg 1501261 aggagaccac gctcccaaag ctgttattga cggagttata aaaggtatag aggcatttga 1501321 tgatctccat atcacacttg tcggtgacaa aacaacgata gaatcacatt taacaactac 1501381 atcagatcgc atcacggtgc tgcacgcaga tgaagtgatt gagcctacgg atgaaccggt 1501441 ccgtgccgtg cgaagaaaaa agaactcatc tatggttctt atggcgcagg aggttgcgga 1501501 aaacagagct gacgcctgca tttcagcggg aaataccggt gcattaatga cagccggtct 1501561 ctttattgtc gggagaatta aaggaattga ccgtccggcg cttgctccga cacttccgac 1501621 tgtttcggga gacggatttc ttctccttga tgtcggcgcc aatgtcgatg ccaaaccgga 1501681 gcacctcgtt caatatgcca tcatgggttc tgtttattct cagcaagtgc gcggtgtcac 1501741 ttcaccgaga gtcggacttt taaatgtcgg aacagaagat aaaaaaggaa acgaactgac 1501801 gaagcagacg tttcaaattt taaaagaaac agcaaacatc aattttatcg gaaacgtgga 1501861 agcgcgagac cttttagatg atgtggcgga tgttgtagta acagacggct ttaccgggaa 1501921 tgttacactc aaaacgctgg aaggctctgc gttgtcaatt tttaaaatga tgagagacgt 1501981 aatgacgtct actttgacat ccaagcttgc agcagctgtg ctgaaaccaa aattgaaaga 1502041 aatgaaaatg aaaatggagt attcgaatta tggcggagca agtctttttg gcttaaaagc 1502101 gcctgtgatc aaggcgcacg gctcttcaga ttcaaatgct gtattccatg cgattcggca 1502161 agcaagagag atggtcagcc aaaatgtggc tgcgctcatt caggaagaag tgaaagaaga 1502221 aaaaacagat gagtagtctg gaggttttta catcatgagt aagattgcat ttttattccc 1502281 gggtcaggga tcacaattta tcggcatggg aaaagagctt tatgagcagg tgcctgctgc 1502341 aaagcgtctg tttgatgaag ccgatgaaac gttggaaaca aaactcagct cgcttatttt 1502401 tgagggggat gctgaagaat taacacttac atacaatgcg cagcctgctt tgcttacgac 1502461 aagcatcgct gttcttgaga aatttaaaga atctggcatt acacctgatt tcacagcagg 1502521 acacagcctt ggtgaatatt ctgcactggt tgcggctggc gctctgtctt tcaaagatgc 1502581 tgtttatact gtcagaaagc gcggagagtt tatgaatgaa gcggtgccgg ctggcgaagg 1502641 agcaatggct gcgattctcg gcatggatgc tgaagcatta aagcaagtaa ccgataaagt 1502701 cacagaggaa ggcaaccttg tacagcttgc gaatctcaac tgtcctggcc aaatcgtcat 1502761 ttccggaaca gctaaagggg ttgagcttgc atctgaactg gcaaaagaga acggcgcaaa 1502821 acgcgcaatt ccgcttgaag taagcggtcc gttccattct gaactgatga aaccggctgc 1502881 tgaaaagctg aaagaggtat tggacgcctg tgacataaaa gacgctgacg ttccggtcat 1502941 ctcaaatgtt tctgctgacg tgatgactga aaaagcagat atcaaagaaa aacttattga 1503001 gcagctttac tctccggttc gttttgagga aagcattaac aagctgatcg cagagggtgt 1503061 tacgactttt attgaaatcg gtcccggaaa agtgctttca ggccttgtga aaaaagtgaa 1503121 tagacggtta aaaacaattg ctgtatcaga tccggaaacg atcgagctgg caattcaaac 1503181 gcttaaggag gagaatgata atgcttaatg ataaaacggc tattgtcact ggcgcatccc 1503241 gcggaatcgg ccgctcaatc gcccttgatc tggcaaaaag cggagcaaat gttgtcgtga 1503301 actactccgg caatgaagcg aaagcaaatg aagtggtaga tgaaatcaaa tcaatgggca 1503361 gaaaagcaat tgctgtaaaa gcggatgtat caaatcccga agatgtacaa aacatgataa 1503421 aagaaacatt gtctgttttt tctacgattg acattctggt taataatgcg ggaattacaa 1503481 gagacaatct catcatgaga atgaaagaag acgaatggga tgacgtcatt aacattaacc 1503541 tgaagggtgt tttcaactgc acaaaagctg ttacaagaca aatgatgaaa cagcgttcag 1503601 gccgcattat taacgtatcg tctatcgtcg gcgtcagcgg aaaccctgga caagccaact 1503661 acgtggctgc aaaagccggc gtcatcggtt taaccaaatc ttctgctaaa gagctcgcca 1503721 gccgaaatat tacggtaaac gcaatagcgc caggatttat ctcaactgat atgacagata 1503781 aacttgcaaa agacgttcaa gacgaaatgc tgaaacaaat tccgctcgcg cgctttggtg 1503841 aacctagcga tgtcagcagt gttgtcacgt tcctagcttc agagggagct cgttatatga 1503901 caggccaaac gcttcatatt gacggcggaa tggtgatgta agttttttct cgaaaatttc 1503961 atcgtagttt ctctagtttt ttaaaaacga atccactata atacttgagg ggaggtgaat 1504021 tgctatggca gacacattag agcgtgtaac gaaaatcatc gtagatcgcc ttggcgttga 1504081 tgaagcagac gtcaaacttg aagcttcttt caaggaagac ttaggtgctg attccctaga 1504141 tgtagttgag cttgttatgg aacttgaaga cgagtttgat atggagattt ctgacgaaga 1504201 tgctgaaaag attgcaacag tcggcgacgc tgtgaactac atacaaaacc agcaataagc 1504261 tgatgctaaa agtcccgccg aaacgcgggg ctttagccct ttattcgtgc agttattaca 1504321 gcatgccgct tttacgcgcg ctgtatccgg tttagtcaga gaagcgcggt gaacctgatg 1504381 tgcctatgga ggttactatg tcaaaacact cacattataa agataaaaaa aagttctata 1504441 aaaaagtaga acaatttaaa gagtttcaag aacggatttc ggttcacttt caaaatgaaa 1504501 agcttttgta tcaagcattt acacattcat cttatgtgaa tgagcatcgg aaaaagccgt 1504561 atgaagataa tgaaaggctt gaatttttag gtgacgctgt tttggaactg acgatctcca 1504621 gattcttatt tgccaaatac ccggctatga gtgaaggaga tttgacgaaa ttgagagccg 1504681 caattgtttg cgaaccgtct ctcgtttcat tggctcacga gctgtcattc ggcgatcttg 1504741 tcctgttggg taaaggcgag gaaatgacag gcggaagaaa gcgtcctgct ctattggcgg 1504801 atgtttttga ggcatttatc ggagccttgt accttgacca aggattagag ccggtcgaaa 1504861 gtttcttaaa agtttatgtg ttccctaaaa ttaacgatgg tgctttttct catgtgatgg 1504921 atttcaaaag ccagctgcag gaatacgtgc agcgggacgg caaaggctct ctggagtata 1504981 aaatctccaa cgaaaaagga cctgcgcaca accgtgaatt tgaagccatc gtatctctaa 1505041 aaggtgaacc actcggagtc ggaaacggcc gttcaaagaa agaagccgaa cagcacgctg 1505101 ctcaggaagc tttagctaaa ttgcaaaaac accatacgaa acaataaaat cccccttatg 1505161 actcaggggg atttcagtat gtatgccgtc ttatttgacc aatgtttatg atagaattga 1505221 aatacttatt acataaggag gatcgctatg ttcctcaaac gtttagacgt tataggattt 1505281 aaatcatttg cagaacggat ttccgtagac ttcgttaaag gcgtgacagc agttgtcggg 1505341 ccgaacggaa gcggaaaaag caacatcacg gatgccattc gctgggttct cggcgaacaa 1505401 tcggcacgct ctcttcgcgg cggaaaaatg gaagacatca tttttgctgg gagtgattca 1505461 agaaagcgat taaatctagc tgaagttacg cttactcttg ataatgatga tcatttcttg 1505521 ccaattgact tccacgaggt gagtgtcaca agacgtgtgt acagatcagg tgagagtgag 1505581 tttctgatta acaatcagcc atgccgcttg aaagatatta ttgatttatt tatggactct 1505641 gggcttggta aagaagcatt ttctattatc agccaaggga aagtggaaga gatcctgagc 1505701 agcaaagcgg aggatcgccg cagtatcttt gaagaagcgg ccggggtgct taaatataaa 1505761 acgagaaaga aaaaagcaga aaataaactg tttgagacac aggacaatct aaatcgggta 1505821 gaagatatat tacatgagct tgaaggacag gttgaacctc ttaaaattca agcttcaata 1505881 gcgaaagact accttgagaa aaagaaagag ctggagcatg ttgaaattgc gctgactgcc 1505941 tatgatatcg aagagctgca tggtaaatgg tcgactctta aagagaaagt gcagatggca 1506001 aaagaagaag agcttgctga atcgtctgct atttctgcga aagaagcaaa gattgaggat 1506061 acaagggaca aaatacaagc gcttgatgag tcagtagatg agctccagca agttttactg 1506121 gtaactagtg aagagctgga aaagcttgaa ggccgtaaag aagtcctgaa agaacgaaag 1506181 aaaaacgctg tgcaaaacca agaacagctt gaagaagcca tcgttcagtt ccagcaaaaa 1506241 gaaacggttc tgaaagaaga gctttcgaag caggaagctg tcttcgaaac gcttcaggct 1506301 gaggtgaagc agttaagggc gcaagtaaaa gaaaaacagc aggctctcag tcttcacaat 1506361 gaaaatgtcg aagagaaaat cgagcagctg aaaagtgatt attttgagct gttaaacagc 1506421 caggcttcga tacgcaacga actccagctt cttgatgacc agatgtccca atccgctgtc 1506481 acattgcaga gacttgcgga caacaatgaa aagcacctgc aggaacggca tgatatttct 1506541 gcgcgtaaag ccgcatgtga aacggaattt gcccgaattg agcaggagat tcacagtcaa 1506601 gtcggtgcat atcgtgatat gcagacaaaa tatgagcaga aaaagcgcca atacgaaaaa 1506661 aatgaatccg ctctgtatca ggcataccaa tacgttcagc aagcgagatc aaaaaaggac 1506721 atgcttgaga cgatgcaggg agatttctcc ggcttttatc aaggtgttaa agaagtgctg 1506781 aaagcgaaag agcgccttgg cggaattcgc ggagcggttc ttgagctgat ttctacagaa 1506841 cagaagtatg aaacggccat tgaaatagcg ctcggcgctt ctgctcaaca cgtcgtgacc 1506901 gacgatgaac aatctgcccg caaagcgatt caatatttaa agcagaattc cttcggccgg 1506961 gcgacgtttc tgcctctttc tgttattaga gaccgccagc ttcaaagccg tgacgcggaa 1507021 acagccgccc ggcattcatc atttctcggg gttgccagtg aacttgtcac atttgatcct 1507081 gcgtatcgaa gcgtcatcca gaatcttctt ggaaccgttc tgatcacaga ggacttaaag 1507141 ggtgcaaacg agcttgcgaa gcttctcggg caccggtacc gcatcgtaac ccttgaggga 1507201 gatgttgtga accccggtgg ttcaatgacg ggcggcgcgg ttaaaaagaa aaataactcc 1507261 ctccttggaa gaagccggga gctagaagat gtgacgaaac ggctcgctga aatggaagag 1507321 aaaacggcac tgcttgaaca agaggtcaaa acccttaagc actccattca ggatatggag 1507381 aaaaaactgg ctgacttaag agaaaccggg gaaggcttaa ggttaaagca gcaggatgtg 1507441 aaaggccagc tgtacgaact tcaagttgcc gagaaaaata tcaataccca tttagagctc 1507501 tatgatcaag aaaaatctgc tctgtcagaa agcgatgaag agagaaaagt gcgcaaacgc 1507561 aagcttgaag aagagctctc tgccgtatct gaaaagatga aacagcttga agaggacata 1507621 gacagactga caaaacaaaa acaaacgcaa tcctcaacga aagagtctct ctccaacgag 1507681 ctgactgagc tgaagatcgc agcggccaaa aaagagcagg cttgcaaggg ggaagaggac 1507741 aaccttgcca gattaaagaa agagctcact gaaacagagc ttgcgttaaa agaagcaaaa 1507801 gaagacttaa gcttcttaac gtcagagatg tcatctagca ccagcggcga agaaaagctg 1507861 gaagaagcag caaaacataa attgaatgac aaaacgaaaa cgatcgaact gattgcatta 1507921 aggcgcgatc agcgcatcaa gcttcagcat gggcttgata cgtatgagcg tgagctgaaa 1507981 gaaatgaaac gcctgtataa acaaaaaaca acgctcttaa aagacgaaga agtcaaactt 1508041 ggacgaatgg aagtcgagct tgataattta ctccaatact tacgggagga atacagcttg 1508101 tcctttgagg gggcaaaaga gaaatatcag cttgaaactg atccagagga agccagaaag 1508161 cgcgtgaagc tgattaaact cgcaattgaa gagctgggta ccgtgaacct cggaagcata 1508221 gatgagtttg agagggtcaa cgaacggtac aagtttctgt cggaacaaaa agaagattta 1508281 acagaagcga aaaatacctt gttccaagtg attgaagaaa tggatgaaga aatgacgaag 1508341 cgctttaacg acacattcgt ccaaatccgc tcacactttg atcaagtttt ccgctcctta 1508401 ttcggaggag ggcgagctga actgaggctc accgatccta acgatctgct tcattcagga 1508461 gtcgagatta tcgctcagcc gccggggaaa aagctgcaaa acttaaacct cctgtcaggc 1508521 ggagagcgtg cgcttactgc tatagcgctc ttattctcaa tcctaaaggt tcgtccagtg 1508581 ccgttttgcg tccttgacga agtagaggct gcgctcgacg aagcgaatgt gttccgattt 1508641 gcgcagtatt taaaaaaata cagcagcgat actcagttta ttgtgattac ccacagaaaa 1508701 ggaacgatgg aggaagcgga tgtgctttat ggcgtaacca tgcaggaatc cggtgtttcc 1508761 aaggtaattt cagttaagct ggaagaaaca aaagaattcg ttcagtaacg aggaaagagg 1508821 ttaaaagatg agctttttta aaaaattaaa agagaaaatc acaaaacaga cagattccgt 1508881 atctgaaaag tttaaggatg gccttgaaaa aacaagaaac tcctttcaaa acaaagtgaa 1508941 tgatcttgta tcccgttacc gtaaagtgga tgaggatttc ttcgaagagc ttgaagaggt 1509001 tcttatcagc gcggatgtcg gttttacaac cgttatggaa ttaatagatg agctgaaaaa 1509061 agaagtcaaa cgcagaaata ttcaagatcc aaaggaagtc cagtcagtga tttctgagaa 1509121 actggtcgag atttataaca gcggagatga gcaaatttca gaactgaaca tccaggatgg 1509181 gcgtttaaac gtaatccttc tggtaggtgt aaacggcgtc gggaaaacaa caacgatcgg 1509241 aaagcttgct cataaaatga aacaagaagg aaaatctgtt gtacttgccg ccggagacac 1509301 ttttagagcg ggagccattg aacagctgga agtatgggga gagcgtacag gagtgcctgt 1509361 cattaagcag acggcaggaa gcgatccggc ggctgtcatc tacgatgctg ttcatgctgc 1509421 gaaagcaaga aatgccgatg tattaatttg tgatacggca gggcgtctcc aaaacaaagt 1509481 aaatctcatg aaagagcttg aaaaagtaaa acgtgttatc gaaagagaag ttcctgaagc 1509541 tccgcatgag gtgctgcttg cccttgatgc cacgaccggc caaaatgcaa tggctcaggc 1509601 aaaagaattc tctaaagcaa caaatgttac cggcattgct ttaacgaagc ttgacggtac 1509661 ggcaaaaggc ggtatcgtcc ttgcgattcg caacgagctt cacatcccgg ttaaactagt 1509721 cggtttagga gaaaaagttg atgaccttca ggaatttgat ccagaatcct atgtgtacgg 1509781 actcttttca gatttagtgg aaaaagccga cgattaagaa aaaggcccca acatcttggg 1509841 gcctttttct tttttatctt cttacttgat aggcgaaatg ataaaggctg ttatcagtgg 1509901 ataccagtct tgactcacca gaaaaaactc tgaatgggat gatgtcatag taatgaacgg 1509961 aaacagatgt gtaatacgta tagtaaccag cagctggccc caaatacatt ggaacctcaa 1510021 atgttccgtt tgcatcagtc gttcctgaag cagtttgtgt tgtgtttccg accttcgtgt 1510081 ccgcttcaaa tcttacgggc gcgtttggca ctggctgtcc gttttggtcg agtaatttgc 1510141 cgcttactgt aatattgtac ttgactcgcc aatattgacc ttgtccgtaa ttgattttac 1510201 cgtatacccc tccatctgtg ctgatatttg tgattgaggc cttataaggt gcctcagcag 1510261 cgtctgcttg ctgtgccggg aaacctattg taaacagggc tgccagacat aacataaaca 1510321 ataaaccgat ttttttcata aaaatcctcc ttaaaatagg gttcatatac aatatcggaa 1510381 taaattggat gatatttagc gtattttgga aaagttaatc gccgctttga caagataaaa 1510441 acttgacagt gtcattaaaa ccgtgtaaac taagttatcg taaagggatt tgacttaaca 1510501 aaggggagag ctcaaatgtc actcgaaaag acaacgagaa tgaattatct gtttgatttt 1510561 tatcagtcgt tgttgacgtc aaaacagaag agctatatgt cgctttatta tttggacgat 1510621 ttctccctag gcgaaatagc cgaagaatat gaggtttcaa gacaagctgt ttatgataac 1510681 atcaaacgaa cagaagcaat gcttgaacaa tatgaagaaa agctgctcct tttgaaaaag 1510741 tttcaggagc gtaaagagat gtttaataag ctgaaggagc ttgcttccgg ttcaaaagaa 1510801 gaggaagaaa ttacagctct gattgaagcg cttgagaaat tagattagga ggcggcaaac 1510861 tatggcattt gaaggattag ccgaccgact gcagcagacg atttctaaaa tccgcggaaa 1510921 agggaaagtc agcgaacaag atgtaaaaga gatgatgcgt gaggtccgtc ttgcgctgct 1510981 tgaggctgac gttaacttta aagtagtcaa ggattttgtc aaaaaagtaa gtgaacgcgc 1511041 tgtaggccaa gacgtcatga aaagtctgac gcccggccag caggtcatta aagttgttca 1511101 agaggaactg actgagctga tgggcggcga agagagcaaa atcgccgtcg caaaaaggcc 1511161 gccgactgtt attatgatgg tcggtctcca aggtgccggt aaaacgacaa caagcggtaa 1511221 gcttgcgaat ctgctgcgca aaaagcataa tcgcaaaccg atgctggttg ctgccgatat 1511281 ttaccgccca gccgcaatta agcagctgga aacactcggc aaacagcttg atatgcctgt 1511341 tttctctctt ggcgatcagg tcagtcctgt agaaatagct aaacaggcta ttgagaaagc 1511401 caaggaagaa cattatgact acgtcatttt ggatacggca gggcgcttgc atatcgacca 1511461 tgaactgatg gatgaactga ccaacgtcaa agaaatcgcg aatccggaag aaattttcct 1511521 ggttgtcgat tcaatgaccg gtcaggacgc tgtgaatgtt gccaaaagct ttaatgaaca 1511581 gctcggttta accggtgttg tgttgactaa gctggatgga gacacacgcg gcggggctgc 1511641 gctttctatt cgcgctgtca caaacacgcc aattaagttt gcaggtttgg gcgaaaagct 1511701 tgatgcgtta gagccgttcc atcctgaacg catggcatca aggattctcg gcatgggcga 1511761 cgtgctgaca ttgattgaaa aagcacaggc cagcgttgat gaagacaaag ccaaagagct 1511821 ggaacaaaaa atgagaacga tgagcttcac attggacgat tttctggagc agctcgggca 1511881 agtcagaaac atggggccgc ttgatgagct tctgcaaatg atgccgggtg caggtaaaat 1511941 gaagggcctg aaaaacatcc aagttgatga aaaacagctg aatcatgtgg aagcaatcat 1512001 caaatcaatg actgttcttg aaaaagaaca gccggatatt atcaatgcca gccggcggaa 1512061 gcggattgca aaaggaagcg ggacatccgt acaggaagtc aaccgtctgc ttaagcagtt 1512121 tgatgaaatg aaaaaaatga tgaagcagat gacaaacatg tcaaaaggca agaaaaaagg 1512181 gtttaagcta ccttttatgt aatcggttat acatgataaa accgttgtta agaaaaaaca 1512241 ctttacaaac acttttatca ttgttaatat actatcttgt tgaaatattt tcggaggtgc 1512301 tagtaaaatg gcagtaaaaa ttcgtttaaa acgtatggga gcaaaaaaat ctcctttcta 1512361 tcgtattgtt gtagcagatt ctcgttcacc acgtgacggc cgtttcatcg aaacagtcgg 1512421 aacttacaac ccggttgcaa aaccagcgga agtaaaaatt gacgaagagc ttgctcttaa 1512481 atggcttcaa actggagcga aaccatctga tacagttcgc aacttgttct ctagccaagg 1512541 aatcatggaa aaattccaca acgctaaaca aggcaagtaa tgactgatca acacttggaa 1512601 gatttgattg tccacattgt gacgccgctt gttgatcatc cagatgacat tcgcgtcata 1512661 agagaagaaa ccgatcaaaa gattgcgctg cgcttatctg tccataagtc agataccggt 1512721 aaagttatcg gaaagcaagg ccggactgca aaagcgattc gaacagctgt atttgcagct 1512781 ggcgtacagt cttctaagaa agttcaattt gaaatatttg actaaaaggg agagggccgg 1512841 cacctcccct ttttttacac gcaaaaaaag ggtaaactga tagaagctta ggcaaaatag 1512901 aaaagcctgg acgagtaaaa gttttaaaag cggggagctt ggtgcgatgc aaattattca 1512961 ccgtgtagcc gttatgcaag tcttaaccga gcgcagtaaa gaaaagcttt tagcttcttt 1513021 tgctgagaag aaacaaatgc ttgaacgaga atgcagccag ctctattttc agcttagaaa 1513081 acatgagaaa gaacagcaaa accctaatat gattgaacaa tttaaaaagg caatagaaaa 1513141 gcgaaaagat gatataaaaa tcattgattt tcaaattgct caagtacata cattgccgct 1513201 tggcagtgag ttgaaagaaa aggaagtcga tgcgctgctg acgattgaag ccggggatga 1513261 ctggcatgag aaaacagcag cgaacaccat cgtcataaaa gacggaaaag taattgaaat 1513321 tcgccagagg tgatcatatg acaaagcgat ggtttaatgt aggcaaaatc gtaaataccc 1513381 acggaatcaa aggcgaagtg cgggtgattt caaaaacaga ttttgccgaa gaacgataca 1513441 agccgggaaa cacgctgtat ttgtttatgg acggccgtaa cgaaccagtg gaggtaacgg 1513501 taaacacaca tagactgcat aagcaatttc atctcctgca gtttaaagaa agacaaaacc 1513561 taaatgaagt agaagagctg aaaaacgcaa tcattaaagt tcctgaagaa gaattaggag 1513621 agctgaatga gggtgaattt tatttccacg aaattattgg gtgtgaagta tttactgaag 1513681 aaggcgaact catcggaaag gtcaaagaaa ttttgacgcc tggagccaat gacgtttggg 1513741 tcatcggacg aaaaggaaaa aaagacgcac tcattcctta cattgaatca gtggttaaac 1513801 atatcgatgt cagggaaaag aaaattgaga ttgaactcat ggaagggtta atagacgaat 1513861 gaaaatcgat tttttgacgc tgtttcccga aatgtttgaa ggcgtgctcg gctcatcgat 1513921 tcttcaaaaa gcccaggaaa aagatgcggt gcagtttcaa gtcgtaaatt tccgagagta 1513981 ctctgataac aagcacaata ctgttgatga ttatccttat ggcggcgggg caggcatggt 1514041 tctcaagccc cagcctgttt ttgacgcggt cgaggacctg acatcaaagg cagccgctgc 1514101 tccgcgtatt atcctcgtat gcccgcaagg tgagcgtttt acccaaaaaa aagccgaaca 1514161 attagctaag gaagagcatt tgctgttcat ttgcggccac tatgaaggct atgatgaacg 1514221 cattcgcgag cacttggtaa cggatgaaat atcaattggc gactttgttc tgacgggcgg 1514281 tgagctccct gcaatgatga tcgcagacag tgtggtcaga ctgcttccgg gtgtactggg 1514341 taaagaggct tcccatattg aggattcctt cagcaccgga cttttagagc acccgcatta 1514401 tacaagaccg gcagattaca aaggtttaaa agtgcctgaa acactcttgt caggaaacca 1514461 tgcaaaaatt gaagaatggc ggaataaaga atcgatcaga aggacctacc taagacgtcc 1514521 ggatctgttg aaagaccacc cgcttacaga gcagcaaaga aagtggattt ctgaatggga 1514581 aaaagaatag attttattgc ataggctatg aaattgtgat aagatactac ttgtggctta 1514641 agcgggctta tccgctgcaa gcttgaaaac gatgttccgc tgtgccggtt tttgtggcca 1514701 agagcatctg ttggaaggag ttgaaaacga tgcaaaaact aattgaagat atcacaaaag 1514761 aacagcttcg tactgatctt cctgcgttcc gtcctggtga cactttacgt gtacacgtta 1514821 aagttgttga gggtaaccgt gagcgtatcc agatctttga aggtgttgtg attaagcgtc 1514881 gtggtggtgg aatcagcgaa acgttcacag ttcgtaagat ttcttacggt gttggcgttg 1514941 aacgtacttt cccagtacac acaccaaaaa tcgcgaaaat cgaagttgta cgttacggta 1515001 aagtacgccg tgctaaactt tactacctgc gtgaacttcg cggaaaagcg gctcgtatta 1515061 aagagatcag acgataatga taacgaacga aaagagcttg ttacctgtaa caagctcttt 1515121 ttttatacag aatttgaaaa tgccggacag gcatcgtaaa atacataaag gacaacaatg 1515181 aatcatgcat actgaagata aaggcggtgt tcgtgtcaca tgacaattca atggttcccg 1515241 ggccatatgg caaaagcaag aagggaagta accgaaaaat taaaattaat cgatatcgta 1515301 tatgaattgg tagatgccag aattccaatg tcatcaagaa acccaatgat tgaagatatt 1515361 ctaaaaaaca agccgcgaat tatgctgtta aacaaggctg acaaagcaga tgcggcagtt 1515421 acacagcagt ggaaagagca ctttgagaac caggggatcc gctctctgtc tattaattct 1515481 gtaaatggac aagggttaaa tcaaattgtg cctgcatcaa aagagatcct ccaagaaaaa 1515541 tttgaccgga tgcgtgcgaa aggtgtgaag ccgagagcga ttcgcgcttt gattatcggc 1515601 attccaaacg tcggaaaatc aacgctcatc aaccggcttg caaagaaaaa catagcaaaa 1515661 acgggagaca gacctggtat tacgacttct caacagtggg tcaaagttgg gaaagaatta 1515721 gagctattag atacaccggg aattttgtgg cctaaatttg aggatgagct tgtcggtttg 1515781 agactggcag tcaccggggc tattaaagac tcgattatca atttgcagga cgtggccgtg 1515841 tttggtcttc gttttctcga agaacattac ccagaacggc ttaaagagcg ttatggcctt 1515901 gatgagatcc cagaggacat tgccgagctg tttgatgcaa taggtgaaaa gcggggctgt 1515961 ctcatgagcg gtgggctcat caactacgat aagacgactg aagtcatcat tcgcgatatt 1516021 cgcactgaaa agttcggcag gctgtcattt gaacagccga cgatgtaaag gcgcgcagaa 1516081 atgcgggtct ttattttttc ttggctgaac cgatacatac agtaagggag aagagaaagt 1516141 gaatacatta accgtaaagg acattaaaga ccgtttgcag gaagtgaagg atgcacaaga 1516201 cccatttatt gcccaatgcg aaaacgaccc gagaaaaagc gttcaaacgc ttgtagagca 1516261 atggcttaaa aagcaagcga aagaaaaagc gctgaaagaa caatgggtga atatgacttc 1516321 ctatgaaagg ctggcaagaa acaaaggatt tcgcttgatt gcaggtgttg acgaggtcgg 1516381 ccgggggcca ttggcaggac cagttgtcgc cagcgcagtc atccttccag aggaatgtga 1516441 aatacttggg ctgacagact ccaaaaagct ttcagagaaa aaacgcgagg aatattacga 1516501 gcttattatg aaggaagcac tggcggtcgg gataggaatt gtagaagcta ctgtgattga 1516561 tgagatcaat atatatgaag cttcaaaaat ggcaatggtg aaagcgatac aggatttgtc 1516621 ggatacacct gattatttgc ttgttgacgc aatgacactt ccgctcgaca cggctcaggc 1516681 gtcaattata aaaggcgatg ccaaaagcgt gtctattgcg gcaggtgcgt gtatcgcaaa 1516741 agtgacgagg gaccgaatga tgagcgctta tgccgaaacg tatcccatgt acggctttga 1516801 aaaaaataaa ggctatggga caaaagaaca tttggaagct ctcgctgcat acggcccaac 1516861 tgaattgcac cgcaaaactt tcgctcctgt tcaatctttc agataaatca ccatggacaa 1516921 ggaggcacct ttttaaaatg aacatacgaa atgatgtgca aaaggcgctg cagcaccttt 1516981 tcgggcgtac agccgtcccg caggaaacat caaaagtaaa cgaagcgcta aacggggaga 1517041 agcgtctcct cttaggaaaa gtgcttcgtt tactaggaga tcagcatgcc ctgatccaag 1517101 tcggcaatca aactgttcag ggaaaacttg aaactcagct tcgtcctcag gcatactatt 1517161 ggttttccta cgaaaaaaaa acggcagagc aaacaggccg tcttcaggtc gttcaaagct 1517221 ttgatcaaaa tcctaaaacc attcaggatg cagctggcaa acttttaaat gctatttcag 1517281 tgaagacgtc aaacgcagct ctcatgatga caggagcgat gctgaaaagc aaaacacccg 1517341 taacagaaaa tgatatcaaa acagctgtcc gctggatgga cacgctgcct tcgcaagaca 1517401 caaaaaaagc agttgaaacg gttctcttcg ctttaaagcg tgatcttccc attcactccg 1517461 agattttgaa tggtgttcac gctgtgaaat cgcctgttcc gttgcatcag cacgtatccc 1517521 agctgctaca ggcaatcgac caaaaccctc agcagagcca aatgatgtca aagctaaagg 1517581 aagcagtcac ggtgctttta aatagtgaaa tcgatgtcca tgcagaacgg ctgattgata 1517641 agcttatttc tttaaccgac aatacgaaag caccttctcc gacgaataca gctggaagca 1517701 gggagcttag cacaccagct ggctcccccg gaaaagccag cctgccgatt gcaaatcaca 1517761 cagcagaaca gggaagcata caagaagagc ctgttaaaac agcagcagac attccaatta 1517821 aagaagcccg ccagctgctg gtgaagctga cggaatctgc tgaaaaaaac agtctccaaa 1517881 ttgtgaaaga agcagcaaat tggattaaag cggctgcttc atcgggtgat agtaagtcac 1517941 ttgcagcttc agctgtttta caggcggcac aagtcacaga tcaggaagcc gaagtctttt 1518001 taaaggctgt tcagcagaca gcaccccatt tggcggataa ggcagatgtt ctttctttct 1518061 tatccaaagt gaaaacggca atcggcgcaa gggacgaggt tgcgttcatt aaagcgtttg 1518121 aacaaggaag cgcagtcaca tctggcgaaa tgcaatccat caagctggct ctttctgcct 1518181 taagagcatc gcatgaggta gccgaaccag tcaaacaaga agccgatcag ctttttcata 1518241 aattaaatgg ccagcttttc atgcagcagg accatccatc atacagccaa attgtaatgt 1518301 catttccgat gttttcgaag tcaggggttc aggacatgac tgttctgttt aaaggaaaga 1518361 aagaagcgga tggaaagctt gatccttccc attgccgcct tttgtttttg ctgcagcttg 1518421 atacactaaa agaaaccgtc gttgattgct tggtacagca aaaagtcatg accattacaa 1518481 tagagactga tttcgagctg caggctgcga tcgatccgat ggtgcccgcg cttaaacagg 1518541 ggctaaagga aatggggtac agcctttcag gggtaaacgc taaaaaaagg gttcacaccg 1518601 aagaaaaggc ttcaatcgat caatatataa caagtatcag tgatcaggaa gtggatgtga 1518661 aaatatgaaa gagcagacac cgatcagaaa agctgttgct ctccattatg acgaacaaaa 1518721 agacaaggcg ccgagagtga ttgccacagg gaagggccat gtagctgaca acattataaa 1518781 agaagcgaaa aaagcagggg tcccgattca agaagatcgg acccttgtcg aattaatgcg 1518841 ccatttgacg gtagatgatc aaattcctga agctctttat gaaacggtag ccgagatttt 1518901 ttcattcatt tacaaattgg acgaaagcgt aaaaaacaaa aaatagctaa aatattcccc 1518961 atccttcttt gaaatttatg tttttaataa agtaaaagtt tgaatgttta gaaggattaa 1519021 aagattttgc atcgaactgt agacaattct tccagtatta ttatagaatg aaagcgcagt 1519081 ctattttagt tttgttacat aagttaggag gatgggaaat gaatatccat gagtaccagg 1519141 gaaaagaagt cctcagaaaa tatggggtat ctgttcctga aggtaaagtg gcttttacag 1519201 cagaagaagc agttgagagt gcaaagagct tatccagctc ggtttatgtc gtaaaggctc 1519261 aaattcatgc tggcggtcga ggcaaagctg gtggggtaaa aatagcaaaa tcattagacg 1519321 aagtaaaagc gtatgccgaa gaactattag ggaagaccct agttacacat cagacgggtc 1519381 cggacggcca agtaataaaa cgcttactta ttgaagaagg ctgcgatatt aaaaaagaat 1519441 attacatcgg tctagtgctt gaccgcgcca cttcaagaat cgttttaatg gcttctgaag 1519501 aaggcggaac ggaaattgaa gaggttgcgg agaaaacacc agaaaaaatc aaaaaagctg 1519561 tcattgatcc agctgttggc cttcaaggct atcaagccag agaaattgca ttcgctatta 1519621 atattccaaa agagctcgtg ggaaaagctg ctaaatttat gcttggacta tataaagcgt 1519681 ttgttgagaa agactgctca atcgccgaaa tcaatccgct tgttgtgact ggcgacggaa 1519741 atgtgatggc gcttgatgca aaattgaatt ttgacagcaa tgcgttgtac cgacaaaagg 1519801 acattatgga atacagagat ttggatgaag aagatccgaa agaaattgaa gcgtccaaat 1519861 atgatctaag ctacatttcc cttgatggaa atatcggctg tatggtaaac ggcgcgggac 1519921 ttgcaatgtc tacgatggat attatcaagc attatggagg agaaccggcc aacttccttg 1519981 atgtgggcgg cggtgcaacc gcggaaaaag tcacggaagc atttaaaatc attctttctg 1520041 atcaaaacgt taaagggatt tttgtcaaca ttttcggcgg cattatgaaa tgtgatgtca 1520101 tcgcagaagg ggttgttgaa gcgactagac aagttggttt gacattgccg cttgtcgtcc 1520161 gtcttgaagg cacaaacgtg gatctaggga agaaaatcct tagtgaatca ggattaaaca 1520221 ttacatctgc ggaatcaatg gctgacggcg cgcagaaaat cgtatcctta gtttaagaaa 1520281 gaatgaaagg caggggacca aataatgagt gttttcatta ataaagatac aagagttatt 1520341 gtgcaaggga ttacaggttc taccgcttta tttcatacga agcagatgct tgaatacggc 1520401 acaaatatcg ttggcggtgt aacacctgga aaaggcggaa cagaagcgga aggtgttcct 1520461 gtatttaata cagtggctga agcagttcaa acaaccggcg ctaacgcgtc tgttatatat 1520521 gtgcccgcac cgtttgcagc tgatgcgatt atggaagcgg tagatgcgga gcttgatctc 1520581 gtgatttgta tcacagaaca tatcccggtt ttggatatgg tgaaggtcaa acgcttcatg 1520641 gaaggcaaga aaacgagact gatagggccg aactgtcctg gtgtcattac gcctgaagaa 1520701 tgtaaaatcg gcattatgcc cggatacatc cataaaaagg gtcatgtagg cgttgtatca 1520761 cgttcaggaa cattaacata cgaagcggtg caccagctct cagaagcggg tgtagggcaa 1520821 tctacagctg ttggaatcgg cggcgaccct gtaaatggaa caaactttat tgacgtttta 1520881 aaagcgttta acgaagatcc tgacacacac gcagtcatca tgattggcga aatcggcggt 1520941 acggccgaag aggaagcggc agagtgggta aaagccaaca tgacaaaacc ggtagtcggt 1521001 tttattggcg gtaaaacagc acctcctggg aagcgcatgg ggcatgcagg cgccattatt 1521061 tccggcggga aagggacagc tgatgaaaaa atcaaaaccc ttaatgcatg cggaatcgaa 1521121 gttgcagaga caccttctgt catgggtgaa accttaatca aggtgctgaa agagaagaac 1521181 ttgttcgaaa cttgtaaaac gcattaataa aaaagggaca gccgtcaagg ctgttcctgc 1521241 tttttctaac aaaaggaggt caatctattg gatcaggccg ctgtctgcct aacgatttgc 1521301 agaatcaatc aattattatc cccatccctt ctattaaaat ggtggaaagc cgatccgtct 1521361 atgtcgctga catcacccgt gttacaaacg gttactcgtg atcaaataaa agcagctgca 1521421 ttaaaaaacg aaatagaaca attttatcca aagctcccgc gtgtacttgc tgcttatcgt 1521481 gagcaaggca ttaacaccat ccctatttct tcaaagcaat atcctttctg gcttaaaagc 1521541 atttatgatc cccctgccgt actgtttgca aaaggtgata tgactcttct ttcgaaaggg 1521601 agaaaaattg gaattgtagg cacaagaaat ccaacagctt atgggaaaca agttgtcaat 1521661 catcttacaa aagagatctg tcgtaaaggt tgggtgattg tcagcggact ggcgtctggg 1521721 atagacggaa tgtcccatgc tgcaagtatt aaggcgaagg ggcggacaat tggcgtcatt 1521781 gcaggcggat ttcaacacat ttatccccga gaaaaccttc agttagcaga tcacatggct 1521841 aaacaccata tcctgctgtc agagcaccca cctgaaacta aaccccaaaa atggcatttc 1521901 cctatgagaa accgtattat cagcggacta agtgaaggcg ttattgtcgt tcagggcaaa 1521961 gaaaaaagcg gttcgctgat tactgcctat caagcattgg aacaagggag agaggtattt 1522021 gccgtacccg gttcattgtt tgacccttac gccggaggtc ctataaaact gatccagcag 1522081 ggggctaaag ccatatggtc agcagaggat attttcgagg aacttcctga gagaaacgtt 1522141 caatatacgg aacccttttg aattatcgtt tgacaaacgg tattgtaata tttaataata 1522201 gtgaggattt aaagttgcat attgttttct atttaattaa tgacgttcat gataaagaat 1522261 gaaatgttga aagccaaata aagacagctg caaaaataaa attgaaatat cttgaaaaga 1522321 gagagaacac ctcttgaggg ggatgaaaat gtctgattat ctagtcatcg tggaatcgcc 1522381 cgctaaggcg aaaacgattg aacgttactt aggtaaaaaa tataaagtaa aagcatcaat 1522441 gggacatgtc cgggatcttc caaaaagtca aatgggagtt gacatagaac agaattttga 1522501 accgaaatat attaccattc gaggtaaagg cccggtatta aaagagctga aaacggctgc 1522561 gaaaaaagcc aaaaaagtgt atctcgcagc tgaccccgac agagaagggg aagcgattgc 1522621 atggcatttg gcacacagtc ttgatttaga tctcaactca gactgccgtg tggtgtttaa 1522681 cgaaattaca aaagacgcta ttaaggaatc gtttaagcat ccccgcatga tcaatatgga 1522741 tttagtggat gcacagcaag cgagacgtat tttagacagg cttgtcggat ataaaatcag 1522801 tccaatctta tggaaaaaag tcaaaaaagg gcttagcgca ggacgcgtgc aatccgttgc 1522861 cctccgtttg attattgacc gtgaaaaaga gattaacgac tttaagcctg aggaatattg 1522921 gacaattgac ggtacgttct taaaaggtca agaaaccttt gaagcgagct ttttcgggaa 1522981 aaacggcaaa aaacttcctt taaatagtga agctgatgta aaagagattc tttctcagct 1523041 caaagggaat caatatacag ttgaaaaagt aaccaaaaag gaacgcaaac gtaatcctgc 1523101 tttgcctttt accacttcta ccctgcagca ggaagcggct cgcaagctca atttcagagc 1523161 gaagaaaacg atgatgattg cacagcaatt atatgaagga attgatttag gaagagaagg 1523221 aacggttggt ctgatcacgt atatgagaac ggattcaacc cgtatttcaa atacggctgt 1523281 tgatgaagca gctgcattta ttgatcagac atatggaaaa gagttcctag gcggaaaacg 1523341 gaagcctgcg aaaaagaatg aaaatgccca ggatgcccac gaagcaattc ggccgacatc 1523401 agttcttaga aaaccaagtg aattaaaagc agtcctcggc agagaccaaa tgagactgta 1523461 taaattaatt tgggagcgtt ttgttgccag ccaaatggca ccggctgttc tcgatacaat 1523521 gagtgtcgac ctgacaaaca acggtttgac atttcgtgca aatggaagta aagtcaagtt 1523581 ttccgggttt atgaaggtgt atgttgaagg aaaagacgat caaatggaag aaaaagaccg 1523641 gatgctgcct gacttacaag aaggcgacac ggtattatca aaagatatag aacctgagca 1523701 gcattttacc cagccgcctc cgcgatatac tgaggcccgg cttgttaaaa cccttgaaga 1523761 acgcggtatc ggccgtccat ccacatatgc tccgacactt gatactattc agcggcgcgg 1523821 ctacgtggca ttggataata aacgtttcgt tccgactgaa ttaggtcaga tcgttcttga 1523881 cttgatcatg gagtttttcc ctgagatcat taacgttgag tttacagcta aaatggagag 1523941 agatcttgat catgttgaag aaggaaatac cgaatgggtc aagattatcg ataatttcta 1524001 caccgatttt gaaaaacgcg tcaaaaaagc cgaatcggaa atgaaggaag ttgagattga 1524061 accagagtat gctggagagg attgtgaatt gtgcagttct ccaatggtat ataaaatggg 1524121 acggtacggt aaattcttag cttgctccaa cttccctgac tgccggaaca cgaaaccgat 1524181 tgtgaaacaa atcggtgtga agtgcccgag ctgcggagaa ggaaacattg ttgagcgaaa 1524241 atcgaaaaag aaacgggtgt tttacggctg tgaccgttat ccggactgtg aattcgtatc 1524301 atgggacaaa ccaattgaac gaaaatgccc gaaatgcgga aaaatgctcg tcgagaaaaa 1524361 actcaaaaaa ggtatacaag tccaatgcgt ggaatgcgat tataaggaag aaccacagaa 1524421 gtagcggtga gcagggtctt gctcaccttc tttgtgtgtt aaaagaaggc cttgaataat 1524481 aaactaggag atgtgaaaga tgaaccaaca aacagtgaat gtaatcggag ccggactcgc 1524541 aggaagtgaa gcagcatggc agcttgccaa acgtgggatt caagtcaaat tgtatgaaat 1524601 gcggccagtt aaacaaacgc ctgcgcatca tacagataaa tttgctgagc ttgtctgcag 1524661 caactctctt cgctctaata cacttgctaa cgctgtcggt gtattaaagg aagaaatgcg 1524721 tgcgcttgat tcagccatta tcgctgcggc tgacgaatgt tcggtgcctg ccgggggcgc 1524781 tcttgcagta gaccgtcatg aatttgccgc aagtgtgaca aatcgggtga aaaatcatcc 1524841 aaacgtaacc gttattaatg aagaagtgac tgaaattcct gaaggcccta ctatcatcgc 1524901 aacgggtccg ttaacatctg aatcgctgtc tgcccagctg aaggagctga ctggagagga 1524961 ctatttatat ttttatgacg cagcggcgcc aattgtagaa aaagacagcc ttgatatgga 1525021 taaagtgtac ctgaaatccc gttatgataa aggtgaagca gcatatttga actgcccgat 1525081 gacagaagaa gagtttgacc gttttcatga agcattaaca tcagcagaaa cagtgccgtt 1525141 aaaagaattt gaaaaagaga ttttctttga aggctgcatg ccgattgaag tcatggcaaa 1525201 acggggtaag aaaacaatgc ttttcggtcc gatgaaacca gttggtctag agcatcctgt 1525261 tacaggaaaa cgcccttatg ccgtcgttca gctcagacag gatgatgctg cgggaacact 1525321 ttataatatt gtaggattcc agacacattt aaaatgggga gaccaaaagg aagttctcaa 1525381 gttgattcca ggacttgaaa atgtagaaat cgtcagatat ggcgtgatgc atagaaacac 1525441 atttattaac tctccaagcc tgttaaagcc gacttatcaa tttaaaaacc gcagtgatct 1525501 gttctttgca ggccaaatga cgggagtaga aggatatgtg gaatcagctg cctcaggact 1525561 tgtagcaggc attaatgcgg cgaagcttgt attgggagaa gagcttgtga tcttccctca 1525621 ggaaacagca attggcagta tggcacatta tattacaaca acaaaccaga agaacttcca 1525681 gccgatgaat gcaaactttg ggcttttgaa agaattgcca gttaaaatta aaaataaaaa 1525741 agaacgaaat gaacaatacg cgaaccgtgc gattgaaaca attcaaacaa tttcgaaaac 1525801 aatataggta ttgattgcaa cctgagcgcg atttgtgata ccatttaaaa gcccttcctg 1525861 gggaggtatt aggcatggag aatgttaaga atttcgtaaa gttattcgtt gaatatttac 1525921 aaattgaaaa aaattattca caatatacta ttgtgaatta tgtggattca attgaagaat 1525981 tcgagacttt cctgcgcgtt caaggtataa atggatttga agaagctgca tatcaagata 1526041 ctaggatttt tttgacagaa gcctatgaaa aaggtttatc gagaagaaca ataagcaaaa 1526101 agatatctgc attaagaagc ttttataagt ttctgatgcg ggaaaagctt attgaagaaa 1526161 atccgtttca gcttgttcat ctgccaaaac aggagaaacg gataccgaag tttctatatc 1526221 aaaaagagct tgaggagctg tttgaagttt cagatataag ccagccggcc ggaatgaggg 1526281 atcaagcgct gttagagctg ctctatgcca ctggaatgag ggtcagtgaa tgctgttcca 1526341 taactattaa cgacgttgat ttatttatgg acactgtgct tgttcacggt aaaggcaaga 1526401 agcagcgcta tatccccttt gggtcttatg cccgcgaagc gttgaaggta tacatgaata 1526461 gcggaagaca gtgcttgctg atgaaggcaa aagaacctca tgatctatta ttcgtaaatc 1526521 aaagaggcgg accgcttaca gcccgtggca tcagacatat tttaagcggg cttgttcaaa 1526581 aagcgtcaag cactttacat atccatccgc atatgcttcg acatacgttc gccacgcatc 1526641 tgttaaatga aggagcggat ttgagaagcg ttcaagaact gctcgggcat tccaatctgt 1526701 cttctacaca gatatacacg cacgtttcga aggaaatgtt gagaaacaca tatatgtctc 1526761 accatccaag agcatttaag aaaaattaaa ggaggccctt tatgtcatct tttcatgcga 1526821 ccacaatatt tgccgtacag cataaaggac gaagcgctat gtccggagac ggccaagtaa 1526881 catttggtca ggctgttgtc atgaaacaca cggcacggaa agtgagaaaa ctgtttaacg 1526941 gcaaagttct tgctggtttt gcgggatctg ttgcagacgc tttcacttta ttcgaaaagt 1527001 ttgaagctaa gcttgaagaa tataacggca acttaaaacg ggcggctgtt gagcttgcaa 1527061 aggaatggcg cagtgataaa gtgctaagaa agctcgaagc catgctgatt gttatgaatc 1527121 aggatacttt gcttctcgta tcgggaacag gcgaggtgat cgaaccagat gacggcattc 1527181 tcgcgattgg atcaggaggc aattacgctt tggcagcggg aagagcactg aaaaagcatg 1527241 ccggggaaag catgtctgca agtgagattg ccagagccgc gttagaaaca gcaggcgaaa 1527301 tttgtgttta cacgaacgat caaatcatac tggaagagct tgaatagaaa ggacttgagg 1527361 cgcatggaaa aaaaaccgtt aactcctaga cagattgtag atcggttaga ccaatatatt 1527421 gtcggtcagc aaaatgcgaa aaaagctgtc gccgtggcat taagaaaccg ctatagaaga 1527481 agtcttctgg atgaaaagct gaaggacgag gtcgttccga aaaacatttt aatgatgggt 1527541 cctaccggcg tcgggaaaac tgaaattgcc agacgaatcg ctaagctttc aggtgcgcca 1527601 tttatcaaaa ttgaagctac taaatttacc gaagtcggct atgtaggcag agatgttgaa 1527661 tcaatggtca gagatcttgt ggagacttct gttcggctta taaaagaaga gaaaatgaat 1527721 gaagtaaagg aacaggcaga agaaaatgca aacaaacgca ttgttcgtct gttagttcct 1527781 gggaagaaaa aacaatctgg tgttaaaaat ccgtttgaaa tgttttttgg aggcagccag 1527841 ccgaatggtg aagatgaggc ggagagccag gaagaagcaa acatcgaaga aaaaagaaaa 1527901 cgaatggcgc atcagctggc tttaggagag ctcgaagact actatgtaac agtagaagtc 1527961 gaagaacagc agccttctat gtttgacatg ctgcagggct cgggtatgga gcagatgggt 1528021 atgaacatgc aggatgcgct gagcggatta atgccaaaga aaaagaagcg gcgcaaaatg 1528081 acagtcagag aagccagaaa agtcctgacg aatgaagaag caagcaaact catcgatatg 1528141 gatgaagtcg gccaggaagc tgttcagaga gcagaagaga gcgggattat ctttatcgat 1528201 gagattgata aaatcgcaaa gaacggcggt gcatcttctt ctgccgatgt ttcaagagaa 1528261 ggtgttcagc gggatatcct tccgattgtt gaaggttcta ccgttgtcac aaaatatggt 1528321 tctgtaaaaa cagaccatgt attatttatt gcagcaggag cgtttcatat ggccaaaccg 1528381 tctgatttga ttcctgagct gcaggggcgt ttcccgattc gtgtagaact gaacaaactc 1528441 acggtagacg acttcgtgag aattttggtt gagccggata atgcgctgct gaaacaatat 1528501 caggcattat tgcagacaga aggtatatct cttgaatttt ctgacgaagc tattcataag 1528561 attgctgaag ttgcttatca tgtgaaccag gacacagata atatcggtgc gagacgcctt 1528621 catacaatac ttgaacgcct attagaagat ttgtcgtttg aagctccaga tgtaacgatg 1528681 gagaaaataa cgattacacc acagtatgtc gaagaaaagc tcggaacgat agccaaaaac 1528741 aaagatttaa gtcaatttat attgtgaaaa atttaatatg aggaatgttt aggaggatta 1528801 tttatcatgg ctttattaca aaaaacaaga attattaact ccatgctgca agctgcggca 1528861 gggaaaccgg taaacttcaa ggaaatggcg gagacgctgc gggatgtaat tgattccaat 1528921 attttcgttg taagccgcag agggaaactc cttgggtatt caattaacca gcaaattgaa 1528981 aatgatcgta tgaaaaaaat gcttgaggat cgtcaattcc ctgaagaata tacgaaaaat 1529041 ctgtttaatg tccctgaaac atcttctaac ttggatatta atagtgaata tactgctttc 1529101 cctgttgaga acagagacct gtttcaagct ggtttaacaa caattgtgcc gatcatcgga 1529161 ggcggggaaa gattaggaac acttattctt tcgcgtttac aagatcaatt caatgacgat 1529221 gacttaattc tagctgaata cggcgcaaca gttgtcggaa tggaaatcct aagagaaaaa 1529281 gcagaagaaa ttgaagagga agcaagaagc aaagctgtcg tacaaatggc tatcagctcg 1529341 ctttcttaca gtgagcttga agcaattgag cacatttttg aggagcttga cggaaatgaa 1529401 ggtcttcttg ttgcaagtaa aattgctgac cgtgtcggca ttacccgttc tgttattgtg 1529461 aacgcactca gaaagctgga gagcgccggt gttatcgagt ctagatcatt aggaatgaaa 1529521 ggtacttata tcaaggtact aaacaacaaa ttcctaattg aattagaaaa tctaaaatct 1529581 cattaatcac aaaaagaacc ctttttgagg gttctttttt tatttcaaat aaaggaaatc 1529641 aataagcttt atttcctggg ttgaaagtct ttctatgtaa taattttaat aaattttgca 1529701 tttttcttca aaaagtttca aaaatgccga aaagaaagga gaaaaaacag aaattctgct 1529761 attttcaggc ttatatcaag gcgagaaatg tagttctaac aatctaggac tttataccta 1529821 gttgcaaaat agataattgt gaggacattt ttttacacga acttcataga ctttatgcct 1529881 gttatttctt acaataagca tatagtttta caattctcga caaggatatt gagggtgaaa 1529941 aaaactgaaa tggaggtaag tggatttgag cttattttct ggaacgatac aaaatcttga 1530001 aaatgccttg agcagagcgg atattaagca aaaagtcata actaataata tcgccaatat 1530061 agatacaccg aactataagg caaaaaaagt ctctttccaa aatttattag atcaagaatc 1530121 ctcgcgtctt gaagcgataa aaacagacta tcgtcatgtt gatttttctg atactgattc 1530181 gaattattca attgttgcga gcggagatac atcgtatcag caaaacggaa acaatgttga 1530241 tgttgacaaa gagatgacag aattggcgca aaatcaaatc aactatcaag ctttggttga 1530301 aagaatgaac ggtaaattta attcgctgaa gaccgtatta acaggaggaa aatgatgaca 1530361 gcttttcata gcttaaatgt ttcagcatcg gctttaacag ctcagcgagt cagaatggac 1530421 gttgtatcat ctaacttagc aaatatggat acgacaagag ctaagcaggt gaatggagag 1530481 tgggtgcctt acagaagaaa aatggtttcc cttcagtcaa aaggtgaatc gttctcttcc 1530541 attctcaatt ctcaaatgag cggaagcggg aatgctggaa acggtgtgaa ggtttcaaaa 1530601 attacggagg atgattcgga ttttaatctt gtctatgatc cgacagaccc tgatgcaaac 1530661 gctgaaggat atgtacaaaa gcctaatgtt gatccattaa aggaaatggt tgatcttgtc 1530721 agcagcacta gatcatacga ggcgaatgtc acggcgatga atgccacaaa gggaatgctg 1530781 atgaaggcgt tagaaatcgg aaagtaggcg aactgttaaa caaggtgaaa aaacgattta 1530841 attaaggtat tagggggata acaatgcaat ccttgaatta tgaagatcag gtgctttgga 1530901 cgcgctggaa agagtggaaa gatcctaaag ccggtgacga cttaatgcgc cgttacatgc 1530961 cgcttgtcac atatcatgta ggcagaattt ctgtcggact gccgaaatca gtgcataaag 1531021 acgatcttat gagccttggt atgcttggtt tatatgatgc ccttgaaaaa tttgacccca 1531081 gccgggactt aaaatttgat acctacgcct cgtttagaat tcgcggcgca atcatagacg 1531141 ggcttcgtaa agaagattgg ctgcccagaa cctcgcgcga aaaaacaaaa aaggttgaag 1531201 cagcaattga aaagcttgaa cagcggtatc ttcggaatgt atcgcccgcg gaaattgcag 1531261 aggaactcgg aatgacggta caggatgtcg tgtcaacaat gaatgaaggt ttttttgcaa 1531321 atctgctgtc aattgatgaa aagctccatg atcaagatga cggggaaaac attcaagtca 1531381 tgatcagaga tgacaaaaat gttccgcctg aagaaaagat tatgaaggat gaactgattg 1531441 cacagcttgc ggaaaaaatt cacgaactct ctgaaaaaga acagctggtt gtcagtttgt 1531501 tctacaaaga ggagttgaca ctgacagaaa tcggacaagt attaaatctt tctacgtccc 1531561 gcatatctca gatccattca aaggcattat ttaaattaaa gaatctgctg gaaaaagtga 1531621 tacaataatg aatttcatgg ttagcgagtg aaaaacatgt caacactatt atggctttta 1531681 agctttatgc tccacggcgt tcttctgtac gctgtcatta tcctgtatac gaggctcgct 1531741 gcagtgaaag aaacagaaaa acagcaaaaa cagatacttg aagagacgga aaacaccttg 1531801 gcggcatttc tgcttgaatt aaaagaagaa aatgagaaac tgatagaaaa taaagcttca 1531861 tctgcaagtc aatcagatga agaatcccaa aagtcaggcc ttcagacctc tgaaacatat 1531921 caagagcggg atccagtcca agaggcagag aatcttcctg aacatattga aggtctgatt 1531981 acagaggttg accgtcggga agagctcgta aacagtgagg tccaatcatt tgaagaccag 1532041 gtcatagaat tatatgaaca gggatattcg gcaagtcaaa ttgcccagaa aatgaagagc 1532101 ggaaagacag aaatcgagct atttttaaaa tttcgctcca aaggtgtaaa ggattcttga 1532161 ttgtcggata aagctgtgtt atattatgtc ttggtgttaa atacacacgc ttaacgattt 1532221 atgcagaggg tgctgcaggc ggcagttctg tacaaaaatg acctaagcgg aggaaaaaaa 1532281 ccattatatt aggaggaaat aacatgtcag tcatttctat gaagcaattg cttgaagctg 1532341 gtgttcactt cggtcaccaa acacgccgtt ggaacccaaa aatgaagcgt tacattttca 1532401 cggagcgtaa cggaatctac atcattgacc ttcaaaaaac agtcaaaaaa gtagaggaag 1532461 cttacaactt cactaaaaat cttgctgctg aaggcggaaa aatccttttc gtcggaacaa 1532521 aaaaacaagc tcaagattct gttaaagaag aagctcaacg ctctggcatg tactatgtca 1532581 accaacgctg gttgggcggt acattaacaa acttcgaaac aatccaaaaa cgtattaaac 1532641 gtcttaaaga cattgaaaaa atgcaagaaa acggtacgtt tgatgtactt cctaaaaaag 1532701 aagtcgttca attgaaaaaa gaattagagc gtcttgaaaa attcctaggc ggaattaaag 1532761 atatgaagga tcttcctgat gcattattca tcatcgatcc tcgcaaagag cgcatcgctg 1532821 ttgcggaagc tcgcaaatta aacatcccta tcatcggtat cgtagatact aactgtgatc 1532881 cagatgaaat cgatgttgtt atcccagcga acgatgacgc tatccgcgct gttaaacttc 1532941 taacttctaa aatggcagat gcaatcttag aagcgaagca aggcgaagaa gaagcggaag 1533001 ttgctgaaga aactgcacca gaaacagaaa caacaactgc gtaacctatt caaaaggtga 1533061 taagagggac tgccttttat cacctttttt caagaaaaat gtgtaatata catactcttg 1533121 tttaaacata taaggaggaa tacaaatggc aattactgca cagcaagtaa aagaactgcg 1533181 tgaaaaaact ggcgcgggca tgatggattg taaaaaagcg ttaactgaaa ctgacggaga 1533241 tatggacaaa gcaattgacc ttttaagaga aaaaggaatt gcaaaagcag cgaaaaaagc 1533301 tgaccgtatc gcagcagaag gttctactct tattaaaact gacggcaaca aaggcgttat 1533361 cctagaagta aactctgaaa ctgatttcgt tgcgaaaaac gaaggtttta aagagcttct 1533421 taacacttta gctgaccacc ttcttgcaaa cacgccagct gatgttgaag aagcaatggg 1533481 ccaaaaaatg gaaaatggct caactgttga agagtacatc acaagcgcag ttgctaaaat 1533541 cggtgagaaa atcactcttc gccgctttac agttcttaca aaagacgaca gctctgcatt 1533601 cggtgcgtac cttcacatgg gcggccgcat cggtgtatta actgttctca acggtacaac 1533661 tgatgaagaa actgcgaaag atatcgcaat gcacgttgct gcagttaacc ctcgttacat 1533721 ttctcgtgat caagtatctg aagaagaaac aaatcatgag cgtcaaatct taactcagca 1533781 agccctccaa gaaggcaaac ctgaaaacat cgtagcgaaa atggttgaag gccgtctgaa 1533841 caaattcttc gaagaaattt gtctattaga ccaagcgttc gttaaaaacc cagatgaaaa 1533901 agtgaaacaa gttattgcag cgaaaaacgc tactgttcaa acttttgtcc gctatgaagt 1533961 tggagaaggc atcgaaaaac gtcaagaaaa ctttgctgaa gaagtaatga accaagtgaa 1534021 aaaataatgg tgaaaagatt tcgcggctaa gtcgcgtctt ttcaggcagt ataggggaca 1534081 cattttgtgt tccctatttt taaaactata tttacaaacc tttttttctc ttgcataata 1534141 gaaaacggca atgtttacac ttggaggtta tcatggaaaa accaaaatac aaacgtatcg 1534201 tattaaagct tagcggggaa gcattggcag gagaacaggg aaatggaatt aacccgactg 1534261 tcattcaatc cattgcaaag caagtgaagg aaatcgctga gcttgaagtc gaagtggctg 1534321 ttgttgtagg cggcggcaac ttatggcgcg gaaaaacagg aagtgacctg ggcatggacc 1534381 gcgcgactgc tgactatatg ggaatgctgg cgacagtaat gaattcgctt gctcttcaag 1534441 acagcttgga aacactcgga atccagtcca gagtgcaaac atccattgaa atgagacaag 1534501 ttgctgaacc gtacataaga agaaaagcga tacgccactt agagaaaaaa cgtgtcgtta 1534561 ttttcgctgc gggcacagga aacccatatt tctcaactga tacgacagct gcactgcggg 1534621 ctgctgaaat tgaggcagac gttattttaa tggctaaaaa taacgttgac ggtgtgtata 1534681 atgctgatcc tagaaaagat gaatcagctg ttaagtatga atcactttct tatcttgacg 1534741 ttcttaaaga cggcctggaa gtcatggatt caacagcttc ctctttatgc atggacaatg 1534801 acattccgct tatcgtcttt tctattatgg aagaaggaaa tatcaaacgt gccgttatcg 1534861 gtgaatcaat cggaacgatc gtgaggggga aataacgtgt caaaagaagt attaactcaa 1534921 acaaaagaaa aaatggaaaa agcaattgct gcttatcagc gcgaattggc tactgtacgc 1534981 gcaggccgtg caaatccatc attattagat aaagtaacgg ttgaatatta cggagcgcag 1535041 acacctttaa atcagttgtc ttctattaac gtgcctgaag ctcgtatgct cgttatcacg 1535101 ccatacgata aaacagcaat cggtgatatc gaaaaagcga ttttaaaagc tgatttaggt 1535161 cttacaccaa caagtgacgg caatatgatt cgaattgcaa ttccggcact aacagaagag 1535221 agacggaaag aattagtgaa agttgtaaaa aaatatgctg aagaagcaaa agtagctgtt 1535281 cgtaacgttc gccgtgatgc taacgatgat ctcaaaaaac ttgagaaaaa cggagacatt 1535341 actgaggatg aactgcgtgc ttccactgaa gacgttcaaa aactgacaga tgaatatgtg 1535401 tcaaaaattg acagtgtcac aaaagacaaa gaaaaagaaa tcatggaagt ttaatgaaaa 1535461 actatgtaca atagataata gtgaaaagac cctctcatgt ttacaggggg tttttttgtt 1535521 aatactgttg attacattga ttatcagcag ggaatgtaac ctttttgggt gacggaggaa 1535581 tctcatgctc aacatactca aaaattggaa gaatcagcaa actgcggctt ccaacttaga 1535641 acgttataca aaagaagaca tacttaaggg agaaattccc gaacacatcg ccattatcat 1535701 ggatggaaat ggccgttggg ctaaaaaacg ctctcttccc agaattgcag gccaccatga 1535761 agggatgaag gtggtaaaaa ggaccacgaa gctcgcaaac gaattaggtg tcaaagtact 1535821 gacattgtat gcattttcaa cagaaaactg gaaaagaccg aaaatggagg tcgatttttt 1535881 aatgaagctt ccggaagaat ttttgaatac gtatcttcca gagcttgttg aggaaaatgt 1535941 acaggttcgg atcattgggg atgaaacggc tttgccggcg cacacattac gtgcgattga 1536001 aaaagctgta caggacacgg cgcaaaacga cggaatgatc cttaattttg ctcttaacta 1536061 tggaggccgt actgaaattg tcagtgctgc aaaatcactc gcggaaaaag tgaaggaagg 1536121 ctctttgaat attgaagaca ttgatgaatc gcttttttct acttatttga tgactgaatc 1536181 tttgcaggat cctgaacttt taattcgaac gagcggcgag ataaggctga gtaattttat 1536241 gctatggcag gttgcctaca gtgaatttgt ctttactgac gtcttgtggc ctgactttaa 1536301 agaagatcac ttcttgcagg cgttaggaga gtttcagcag agaggccgga ggtttggcgg 1536361 aatttagagg atggtggaca tgaaacaaag aattttgaca ggtgttctgg cagcaattgt 1536421 atttttattt ttggttattg tcgggaaatt gccgttcacc atattaattt atgctatggg 1536481 cagtgtggcg ctttttgaac ttttacggat gaaaaagctg aagctggttt cactgccggg 1536541 tttgatcggt cttttattat tgtggatgtt cttattacca agccagtatt cgttttttga 1536601 agcggacggg atttccaaaa tggaaatcgc tttatttgcg gtactgctat tgctgactta 1536661 cacagtgttg gtcaagaaca cctttacttt tgatgaagtc gggtttatta cgcttgcagc 1536721 aatttacatc ggaatgtgtt ttcattattt tatcgaaatc agaaatcttg accaatacgg 1536781 attaacatac attttttatg cgtgtgttgt catttggtcc accgattccg gtgcctattt 1536841 tgtcggtaaa tcgcttggga agcggaaact gtggcctgaa atcagtccga ataaaacagt 1536901 ggaagggttt gcaggcggaa ttgtcatcgc acttgtattg gcgacgattt ttcagcttgt 1536961 tgcacaactt ccgatcccgt atatctatct gctgttgatc acgctgtttt tgtctgtttt 1537021 tggacaactg ggagatttag tggaatccgc cttgaaaaga cattacgatg taaaggattc 1537081 tgggaatatt cttcccgggc atggcggtat attagaccgt tttgacagtt tcttgtttgt 1537141 catgcctttc ttgtactttc tgcttgccct tttttcataa aaaagtctaa tatgaatatg 1537201 agactgatca tgcagcaata agaataggag tagtggcaac tttgaaaaat atttgtcttt 1537261 taggagcaac aggatcaatc ggcgaacaga ctcttgatgt actgcgtgca catcaagacc 1537321 aatttcagct ggtatctatg tcgtttggca gaaatattga taaggccgtt ccaatgattg 1537381 aggtctttca gccgaagttt gtctctgtcg gtgatctgga tacatatcat aaattaaaac 1537441 aaatgtcttt ttcttttgaa tgccaaatcg ggctgggaga agaaggactg atagaagcag 1537501 cagtgatgga ggaggttgac attgttgtca acgctttgct tggaagcgtc ggtcttatcc 1537561 cgacattaaa ggcaattgaa cagaaaaaaa caattgcgct tgcaaataag gaaactcttg 1537621 tcactgcagg gcatatagta aaagaacatg ctaagaaata tgatgttccg ctgctgcctg 1537681 ttgacagtga gcattcagcc atttttcaag ctcttcaagg cgaacaggct aaaaacattg 1537741 aacgcctcat cattacggca tccggcggaa gttttcggga caagacgcgg gaggagctcg 1537801 aatcagtaac ggttgaagat gcattaaaac atccaaactg gtcaatgggt gcaaaaatta 1537861 caattgattc ggctacaatg atgaataagg gattagaggt gatcgaggca cactggcttt 1537921 tcgatatacc ttatgaacaa attgatgtgg ttttacataa ggagagcatc atccattcaa 1537981 tggttgagtt ccatgataaa agtgtgatcg cacagctcgg aactccggat atgagagtcc 1538041 ccattcaata tgcgctcact tatcctgacc gattgccatt accagatgcg aaaaggcttg 1538101 aattatggga aatcggcagc cttcattttg agaaagctga ttttgacagg ttccgatgct 1538161 tacaatttgc ttttgaatca ggtaaaatag gaggaacaat gccgacagtg ctaaatgcgg 1538221 caaacgaagt agctgtcgct gcctttttag ctggcaagat accgtttttg gctattgaag 1538281 actgtatcga aaaggcacta acccgccatc aattactgaa aaaaccgagc ctggcggaca 1538341 ttcaagaagt ggacaaagat acccggggat acgtcaattc aatactcaca taaggtggta 1538401 tgttcgtgaa tacagttata gcgtttatca ttattttcgg aacgctcgtt ttcttccatg 1538461 aactgggcca tttattgcta gcccaaagag cgggaattct ctgccgtgaa tttgcgatcg 1538521 gcttcggtcc aaagattttt tctttcaaaa aaaatgaaac agtttatacg atcaggctgc 1538581 ttccggtcgg cggatttgtt cgtatggccg gcgaagatcc ggaaatgatt gaggtgaaac 1538641 ccggatacac ggtcgggctt ctgtttaata aggaagatca agttgagaaa gtcatcatca 1538701 atcaaaagga aaaatatccg gatgctttag tcattgaagt ggaaacagcg gatctagagc 1538761 atgacatgaa gatcaccggt tatgaacagg ggaaagagga cgaactttcc agctttactg 1538821 tcagcgaaac atcctttttt attgtagacg gagaagaagt gcagattgcg ccgtataatc 1538881 gccaatttgg ttccaaacct gtatggcagc ggattaaagc aattgctgca gggccgatta 1538941 tgaactttat tttagcttac gtcattttag tgatgcttgg gctgattcaa ggcgtaccgt 1539001 caaatgaacc tatgctcggg cagctgacag acaatggacg ggcggctgaa gcagggctaa 1539061 aagaagggga ttatatccaa agcattaacg gagagaaaat gaggtcttgg actgacattg 1539121 tctccgctgt aaaagaaaac ccggagaaag aaatggacgt tgcagtaaaa agagataaca 1539181 aaacgcttca tatttcggtg actccggaag ctgttaaaga tgagaacaaa aaaacaatcg 1539241 gacgtttcgg ttcctatgcg ccgactgaaa aaggcgtact ctcagcggtt gcttacggcg 1539301 cgacatcaac agttgatgtc accaaagcca ttttaaccaa tctgagcaaa ttagtaacag 1539361 gccaatttaa actcgatatg ctgtcaggtc ctgtcggcat atatgacatg acagaccaag 1539421 tggcgaaaac agggatcgtg aacttatttc agtttgcggc gtttttaagc attaaccttg 1539481 ggattgtcaa cctgcttccg attccggcac ttgacggagg aagactgttg tttctattta 1539541 ttgaagcgat tcggggcaaa ccgattaaca gggaaaaaga agcatttgtt gtgtttatcg 1539601 gagtagcttt cttaatgctt cttatgctgg ttgtcacatg gaacgatatc cagcggctgt 1539661 ttttgtaaac gaaaagtaaa tcaatcagag gtgcgaagaa atgagacaaa gcttgacgct 1539721 tattcctacg ctccgtgaag ttccagctga tgccgaagca aaaagtcatc agcttcttct 1539781 gagagcagga tttatcagac agaatacgag cggggtatac agctatatgc ctcttgcgta 1539841 taaggtgatt caaaacattc agcagattgt tcgagaggaa atggagaaaa ttgatgccgt 1539901 agaaatgctc atgcccgcat tgcagcaggc agagacatgg caggaatcag gcagatggta 1539961 tacgtatggt cccgaactga tgagactaaa agaccgtcat ggccgtgaat ttgctttagg 1540021 ggcaacgcat gaagaggtta tcacttcgct tgttcgcgat gaggttaaat cttataagcg 1540081 tctccctctg actctttatc aaattcagtc taagttcaga gatgaaaaac gtcctcgctt 1540141 cggtttgtta agaggccgcg aatttattat gaaggatgcg tactctttcc atgcatctgc 1540201 agagagcctg gatgaaacgt atcaaaaaat gtacgaggcc tattctaata tttttgcccg 1540261 ctgcggcatt aatgtaagac ctgttatcgc tgattcaggc gcaatgggag gaaaggatac 1540321 gcacgaattt atggcacttt ctgcgatcgg agaggatacg attgcgtatt ctgatgaatc 1540381 acagtacgcg gctaatatcg agatggctga agttcttcac caggaagttc cttcagatga 1540441 agagcctaaa gctctagaga aggttcatac gcctaacgtg aaaacaatcg aagaactgac 1540501 tgcgttctta caggtttcgg ctgaagcgtg cattaagtca gtattgttta aagctgatga 1540561 ccgttttgtc ttagtgcttg taagagggga tcatgaagtt aacgatatta aagtgaaaaa 1540621 cttgcttcat gcagaagttg tagagcttgc tacacatgaa gaggtcattc agcagctcgg 1540681 aacagagcca ggctttgtag gccctgtcgg tattcatcag gatgtggaag tatatgccga 1540741 tcaagctgtg aaagcaatgg ttaatgctgt tgccggggca aatgaaggag atcatcatta 1540801 taaaaatgtc aatgtgaatc gtgacgcgca aattaaagaa tttgctgatc ttcgttttat 1540861 taaagaaggt gatccttcac cagacggcaa gggaacgatc cgttttgctg agggaatcga 1540921 agtcggacaa gtctttaagc tcggaacacg ctattcagaa gcgatgaatg cgacatattt 1540981 agatgaaaac ggacgcgcgc agccaatgct gatgggctgt tacggaatcg gtgtgtcaag 1541041 aacgctttct gctattgctg aacagcatca cgacgaaaaa ggcttaatat ggccaaaaag 1541101 cgttgcgccg tacgatcttc atattcttgc tttgaacatg aaaaacgatg ggcaaagaga 1541161 gcttgctgaa aagctgtatg ccgatttaaa agcggaaggc tatgaagtgc tctatgatga 1541221 ccgtgctgag cgtgccggcg taaaattcgc tgattcagat ttaatcggcc ttccaatccg 1541281 catcactgtc ggaaaacgag ctgacgaagg aatcgtcgaa gtgaaaattc gtcaaactgg 1541341 tgagtcaact gagatttcag tagacgaatt atctgcgttt atcagcaagc agtaatcacc 1541401 ataacgattt atcaaaaaac atgttaaaat agaaataata gaaggtacct cattgcctga 1541461 ggtaccttca cttatgatgt ttttagggag ggatactgtc ttaatggaac agttatcagt 1541521 aaacagaagg cagtttcaaa ttcttctgca gcagattaat atgacagatg ataccttcat 1541581 gacatacttt gaacatggcg agattaaaaa gctgacaatt cacaaagctt ctaagtcttg 1541641 gcattttcat tttcaattta aatctttgct gccttttcaa atatatgaca cattaacaac 1541701 gaggctgacg caatcgtttg cccacatagc aaaagtgaca tcttcaattg aagttcagga 1541761 tgccgaggtc agtgaaagta tcgttcaaga ctactggtca cgctgcattg aagaactgca 1541821 gggcatttcg ccgccgatta tcagtctttt aaaccagcaa aaaccgaagc tgaagggcaa 1541881 taaactgatt gtcaaaacca aaacagatac agaagcggct gcgctaaaga acaaatacag 1541941 ttccatgatt caagcagaat accgtcaatt tggctttccg gatcttcagc ttgatgctga 1542001 aatatttgta tccgagcaag aagttcaaaa gtttcgggag caaaagcttg cggaagacca 1542061 agagcgggct atgcaggcct tgattgaaat ggagaagaaa gataaagaaa gtgatgaaga 1542121 ccaagcacca tctggtcctc ttgttatcgg ttatcaaatt aaagataacg aggaaatccg 1542181 aacacttgac agcatcatgg acgaagaacg gagaattacg gtccaaggtt atgtgtttga 1542241 tgtggagacg cgcgagctga agagcgggcg cacgctgtgt atcttcaaaa ttacagacta 1542301 tacaaatagt attttgatca aaatgtttgc acgtgaaaaa gaagatgcgg cgctgatgaa 1542361 gtctctgaaa aaaggaatgt gggtaaaagc acgcggaagc attcaaaatg atacatttgt 1542421 cagagacctt gtcatgatcg caaatgacgt aaacgaaata aaagcaaaaa cccgtgaaga 1542481 ttcagcacct gaaggagaaa aaagagtgga attgcatctt cattccccaa tgagccaaat 1542541 ggatgctgtt acgggtatcg gaaagcttgt cgaacaggcg aaaaaatggg ggcatgaggc 1542601 catcgctttg accgaccatg ctgtcgttca atccttccct gatgcgtatt ctgcggccaa 1542661 aaagcatgga attaaaatga tttacgggat ggaagcgaat ctcgtggatg atggcgtgcc 1542721 aattgcttat aatgccgcac atcgtctgct cgaagaagaa acatatgttg tttttgacgt 1542781 tgagacgaca ggattgtctg ctgtatacga taccattatt gagctggctg cagtaaaagt 1542841 aaaaggcgga gaaattattg ataaatttga ggcgtttgcg aacccgcatc gtccgctttc 1542901 cgccacaatc atagagctga cagggatcac agatgatatg ctacaagacg ctccggatgt 1542961 cgtagatgta ataagagatt tcagagaatg gattggcgat gatattcttg tcgctcataa 1543021 tgcaagcttt gatatgggat tcttaaatgt agcctataaa aaacttcttg aagtcgaaaa 1543081 agctaaaaac ccagtcattg atacgcttga acttggacgt tttctctatc cggaatttaa 1543141 gaaccaccgg ttgaacacac tttgtaaaaa gtttgatatc gagctcacac agcatcaccg 1543201 tgcgatctat gatactgagg caaccgctta tttgcttctg aaaatgctga aagacgcagc 1543261 tgaaaaaggt attcagtacc atgatgagtt gaatgaaaat atgggtcagt ccaatgctta 1543321 tcaaagatca agaccgtatc atgcaacatt acttgccgtg aacagcacgg gacttaaaaa 1543381 tttatttaag cttgtgtcac tttctcatat tcattatttt tacagagtgc cgcgtattcc 1543441 gagatctcag cttgagaaat acagggaagg gcttctgatc ggttctgctt gtgacagggg 1543501 agaggttttt gagggaatga tgcaaaaatc gcctgaagag gtggaagata tcgcgtcatt 1543561 ctatgattac cttgaggttc agccgcctga agtgtatcgt cacttgctgg agcttgaact 1543621 ggtccgtgat gaaaaagcgc tgaaagaaat tattgcgaat atcacgaagc tgggggaaaa 1543681 gcttaataaa ccggttgttg ctacgggaaa tgttcattac ttgaatgatg aggataaaat 1543741 ctacagaaag attttaatat cctcacaagg cggggcaaat ccgctgaata ggcatgaact 1543801 gccgaaagtg catttcagaa cgacagacga aatgcttgaa gctttttctt tcttaggtga 1543861 agaaaaagcg aaggagatcg tagtcaccaa tacccaaaag gttgcttctt tagttgatga 1543921 catcaagccg attaaagatg atttatatac gccgaaaatc gaaggcgctg atgaagagat 1543981 cagagaaatg agctatcagc gtgcaagaag catttacggg gaagagctgc ctgaaattgt 1544041 cgaagcgcgg attgaaaaag agttaaagag tattattggc cacggatttg ctgttattta 1544101 cttgatctct cacaaacttg taaaacgttc actagatgac gggtatctcg ttggttcccg 1544161 tggttccgta ggatcttcat tagttgcgac acttactgag attactgagg taaacccgct 1544221 gccgccgcac tatgtttgtc ctgagtgcca gcattctgag ttctttaatg acggttctgt 1544281 cggttctggt tttgacctgc ctgacaagac atgccctcat tgcggaacgc ctttgaaaaa 1544341 agacggccat gatattccat ttgaaacgtt cttaggattt aaaggggaca aagtacctga 1544401 tatcgatttg aacttctcag gggaatatca gccgcaagca cacaattaca caaaagtatt 1544461 gttcggagaa gacaatgtat atcgtgcggg aacaataggc acggtggcag aaaaaacagc 1544521 ctacggttat gtaaaaggct atgccggaga caacaatctt catatgcgcg gtgccgaaat 1544581 agatcggctc gtacagggat gcacaggtgt aaaacgtaca actggacagc accctggcgg 1544641 tattatcgta gttccggatt atatggatat ttatgatttt tcaccgatcc agttcccggc 1544701 agatgccaca ggttcagagt ggaaaacgac tcattttgat ttccactcca tccatgacaa 1544761 cctgttaaaa cttgatattc tcggacacga tgacccgact gttattcgga tgcttcaaga 1544821 cttaagcgga atagatccga aaacaattcc gacggatgat cctgaagtga tgaagatctt 1544881 ccagggaacc gaatcactcg gtgtgactga agaacagatt ggctgtaaaa cgggcactct 1544941 tggaattcct gaattcggaa cccgatttgt ccggcagatg cttgaagata caaagccgac 1545001 cactttttct gagctcgttc agatttcagg cttgtctcac ggaactgatg tatggcttgg 1545061 caatgcacag gagctcatcc acaataatat ttgtgagctg agtgaggtta tcggctgccg 1545121 tgatgacatt atggtttatt taatctatca aggccttgag ccgtcccttg cctttaaaat 1545181 catggaattc gtgcgtaaag gaaaaggatt aacgcctgaa tgggaagaag aaatgaaaaa 1545241 taacaatgtc ccagactggt atattgattc ctgtaaaaag attaaataca tgttcccgaa 1545301 agcccacgcc gcggcatatg tcttaatggc agtccgcatt gcttacttta aagtgcatca 1545361 tgctcttttg tattatgcgg cttattttac cgttcgtgca gatgactttg atattgatac 1545421 aatgatcaag ggctctacag caatcagagc ggtaatggag gatataaacg ctaaaggact 1545481 tgatgcttca ccgaaggaaa agaaccttct gactgtttta gaattagcgc ttgagatgtg 1545541 tgagagaggc tattcattcc aaaaagtcga tttatatcgc tccagcgcca cagagtttat 1545601 tattgacggc aacagtctta ttccgccgtt taactctatt ccagggttag ggacgaacgc 1545661 tgctttgaac attgtaaaag ctcgcgaaga aggcgaattc ctctcaaaag aagatttgca 1545721 aaagagaggg aaagtatcaa aaacgatttt agagtactta gatcgccatg gctgtctgga 1545781 gtcactgcct gatcaaaacc aattgtcact gttctaatat ggaaagcaga atttctcaga 1545841 aattctgctt ctatgcatac ataagcgcaa aaagtgccat cgtaatatta gagtttctgt 1545901 cacttgctta ggtatgaagg taagcgtata tccatttgca ataaaaatat ggttatggta 1545961 tagttttatt ggaaatgcta acgattaccg aggcaaagag tggggaaacc cgctcttttg 1546021 tattgaacag gagaattttg tctcgacatg ttcatcgttt actttttagc ccctgctctt 1546081 ttgaagcagg gtttttatgc agagtgacga gacgaatatg agatcgacag cacaaggagg 1546141 aagaacatga gcaaaaaagt gactgacacc gttcaagaaa tggctcagcc aatcgtagac 1546201 agccttcagc tggaactcgt tgacattgaa tttgtcaaag agggccaaag ctggttcctt 1546261 cgcgtgttta ttgattccga tgacggtgtg gatattgagg aatgtgccaa agtaagcgaa 1546321 gctttaagcg aaaagcttga tgaggcagac ccaatcagcc aaaattactt tcttgaagtc 1546381 tcatctccag gagctgagcg tccgctaaag aaaaaagccg atttcgaaaa atcactagga 1546441 aaaaacgtat acattaagac gtatgagcct attgacggcg taaaagtgtt tgaaggtgaa 1546501 ctggctgaat ttgatggaca aacagtgaca gttgagatca cgatcaaaac aagaaagaaa 1546561 cggatcaata ttccgtatga aaagatagct aatgcaagat tagctgttac attctaatga 1546621 atacaaatgt tttaaggggg gagaccgtta aatgagcagt gaattattag atgctctcac 1546681 gattcttgaa aaagaaaaag gcatcagtaa agaaattatc atcgaagcaa tcgaagctgc 1546741 gttaatttct gcttataagc ggaattttaa tcaagcgcaa aatgtacggg tggatctaaa 1546801 ccgtgaaact ggctccatcc gtgtatttgc aagaaaagat gtcgttgacg aagtatacga 1546861 ccagagatta gaaatctcaa ttgaagaggc acagggcatc catccggaat atatggtcgg 1546921 cgatgtcgtc gaaatcgaag ttacacctaa ggatttcggg cgcatagctg ctcaaacagc 1546981 gaagcaggtc gtcacacagc gtgtgcgcga agctgagcgc ggtgtgattt attctgaatt 1547041 tatcgaccgt gaagaagaca tcatgacagg gatcgtccag cgtctggaca ataaatttat 1547101 ctacgtgtct ttaggcaaaa tagaagcctt gctgccggtt aatgagcaaa tgccgaatga 1547161 aagctacaag ccccatgacc gcattaaggt atatatcaca aaagtagaaa aaacaacgaa 1547221 gggtccgcag atttatgtgt caagaacaca tccaggcctg ttaaagcgtt tgtttgaaat 1547281 tgaagtgcct gaaatttatg atggaactgt cgagctaaaa tctgttgcca gagaagccgg 1547341 cgaccgttcg aaaatttctg ttcgcacaga tgatcctgac gttgatcctg tcggttcatg 1547401 cgtagggcct aaaggccagc gtgtgcaagc aatcgtcaat gaattaaaag gtgaaaaaat 1547461 tgacattgtc aactggtcca gtgatcctgt agaatttgtc gcgaatgcgc tcagcccttc 1547521 caaagtgctt gatgtcattg ttaatgaaga agaaaaagcg acaactgtta ttgttcctga 1547581 ttaccagctg tctctggcaa ttggaaaaag aggacaaaac gcacgcttag ctgctaaact 1547641 gacaggctgg aagattgata ttaagagcga aacggacgca agagaacttg gaatctatcc 1547701 gagagaactt gaagaagatg atgagccgct ctttacggag cctgaaactg ctgaatcgga 1547761 tgaataagag gtgactttag gtgaataaac acaaaaagat cccattacgc aaatgtgtag 1547821 tgactggtga aatgaagcct aaaaaggaac tgatccgagt tgtacggtcg aaagaaggcg 1547881 aaatctcagt agacccgacc ggaaaaaaga atgggcgggg tgcttattta acgctggata 1547941 aagagtgcat cttagcagca aaaaagaaaa acactttgca aaatcaattt caatcacaaa 1548001 tcgatgacca gattttcgat gaattgctgg aactggcgga aaaggtgaaa aaataaaatg 1548061 tctggaatgg aatggtttcc cttgctgggt ctggccaatc gagctcgtaa ggtcgtgtca 1548121 ggcgaagact tggtaataaa agaaatcagg aatgcgcgtg caaagcttgt cctgcttaca 1548181 gaggatgcat catctaacac agcaaaaaaa gtaactgaca agtgcaatta ttataaagtc 1548241 ccttataaaa aagtcgagag tcgcgcggtt cttggacgct ctatcggtaa agaagcccgt 1548301 gtcgttgtcg ccgtcactga ccaaggtttt gcgaataagc tgatcagctt gctcgattaa 1548361 tatttttggg ggtgaacgaa tggctaaaat gagagtatac gaatatgcaa aagcgttaaa 1548421 tgtttcaagt aaggaaattt tgaccgcact gaagaacatg gatttagaag tgaataatca 1548481 catggccatg cttgaagaaa aggccattaa aaagctagat gccaaatata aaaaaggcgg 1548541 cgcagctgct aaatctcaaa agccagcaga aacgaacaaa aacaaacagc cacaaggggt 1548601 taatcagcaa tcagctggaa atcaaccaaa taaaattcga gacggaaaga agaatgacgt 1548661 gcagaataat caatttaaca aaaacaagaa gaataacaac aacaaaaaaa ataaacgcaa 1548721 caacaacaat aataaaaacc aacatcagca aaagcctgta aagccgaaaa aagagcttcc 1548781 tgagaaaatt acattctctg gcactttaac agttggcgca cttgctgaag agcttggcaa 1548841 agagccttca gaactcatta aaaagctgat gcttcttggc gtaatggcaa ccattaacca 1548901 agagcttgat aaagacacaa tcgaactcat tgcatcagaa tatggtgttg aaacagaaga 1548961 ggtcattgtg cttgaagaaa cagagctgga aaaatacgaa gagcctgata atgaagagga 1549021 tcttgaaatt cgtcctcctg tcgtgacaat catgggccac gttgaccatg ggaaaacaac 1549081 gcttcttgac agcatccgta aaacaaaggt tgttgaaggg gaagcaggcg gaatcactca 1549141 gcatatcggc gcttatcaaa ttgaagagaa cggcaagaaa atcacgttct tggatacacc 1549201 gggccacgcc gcatttacaa caatgcgcgc acgcggtgca gaagtaactg atattacgat 1549261 tcttgtcgta gctgccgatg acggtgtcat gccgcaaaca gttgaagcga ttaaccatgc 1549321 aaaagcagca gaggttccaa tcatcgttgc tgtgaataaa atagataaag aatccgcaaa 1549381 ccctgaccgt gtaatgcaag aactgacgga atacggactt gtccctgaag cttggggcgg 1549441 agaaaccatt tttgtgccgc tttccgcttt aactggaaaa ggcattgatg agctcgttga 1549501 aatgattttg cttgtcagtg aggtagagga actgaaagcg aatccgaatc gtcaggcaaa 1549561 aggaacggtt attgaagctg aactcgataa aggcagaggg tcagtcgcga cgttgctcgt 1549621 acagactgga acactgcatg tcggtgatcc gatcgtagtc ggcaatacat ttggccgtgt 1549681 ccgtgcaatg gtcaacgaca ttggccgccg tgtgaaaact gccggcccgt caactccggt 1549741 tgaaattacc ggtttgaatg atgtccctca agcgggagac caattccttg tctttaagga 1549801 tgaaaaaaca gctcgttctg tcggtgaagc ccgtgcttcg aaacagcttg aagagcagcg 1549861 cagcgataaa gcgaagctca gtcttgatga tttatttgag caaattaagc aaggtgatgt 1549921 aaaagacatc aacctcatcg taaaagctga cgttcaagga tctgctgaag ctttaacggc 1549981 tgcacttcaa aaaattgaag tagaaggcgt taaagtgaaa atcatccata caggcgttgg 1550041 tgcgattact gaatcagaca ttatcttggc atctgcttcc aatgcaattg ttatcgggtt 1550101 taatgtgaga ccggacggaa atgctaagag tacggctgaa gctgaaaatg tagatattcg 1550161 acttcaccgt atcatttaca aagtaatcga cgagattgaa gctgccatga aaggtatgct 1550221 tgatcctgaa tatgaagaaa aagtaattgg tcaagtagaa gtacgccaaa cattcaaagt 1550281 atctaaaatc ggtacaattg ccggcggata tgttactgaa ggaaccatta cgcgcgacag 1550341 cggcctccgt ttaattcgtg acggcgtcgt catctttgaa ggcgaagtag atgttctgaa 1550401 acgctttaaa gacgatgtga aagaagtttc acaaggctat gaatgtggta ttacaattaa 1550461 gaaatacaat gacattcgtg aaggtgacat ccttgaagcg tttgtcatgc aagaaattga 1550521 aagaacgtga tcggatttgc ggagtgtgaa tgcatcattt atgatgcagg atcgctaaaa 1550581 gaaaagcgtg ccgttctgaa gcggatttta accagggttc aaaacaagtt caatgtttcg 1550641 atttcggaga ttggctatca ggacacctgg caaagaacca gcttcggaat cgccgctgtt 1550701 tcttcctctc gcgttcaaac agaaaaagaa ctgcagcgcg tcctagcgtt tatcgattct 1550761 tttcctgaaa ttgaacggac gatcactagg acagagtggt tttaacttag aggtgattga 1550821 attgagtatg agagcaaacc gtgtcggcga gcaaatgaaa aaagaactcg gtgatattat 1550881 cagccgcaag ctgaaagacc cgagaattgg ttttctgaca gtaacggatg tacgtgtatc 1550941 aggtgatttg caaattgcaa aggtgtatat ctcggttctc ggtgacgaga aaaaacggga 1551001 agaagcgctg aaagggctgg caaaagcgaa aggatttatc cgatccgaaa tcggcagccg 1551061 catcagactt cgaaaaacgc ctgaaattga atttgagttc gatgaatcaa tcgattacgg 1551121 gaatcggatc gaaacactga ttcacgaatt acattcagag aaaccatctg aataaaaaaa 1551181 gagaggatag gcgtatatcg tctgtcctct ttcttcgttt ataagaaaaa aactcaaaag 1551241 aaggagtgaa aggcaaatgg ttaacggagt tctcctttta cataaacctg ttggcatgac 1551301 atcgcacgac tgtgtcatga agatccgaaa gctgttaaaa acaaaaaaag taggacatac 1551361 aggaacgctc gatccggaag tatcaggcgt gcttccgatt tgtgtaggaa gagcgacaaa 1551421 aatagtcgaa tacttaactg aaaaatctaa aacgtatgat gcagaaataa cattgggctt 1551481 ttcaaccaca acagaggatc aaaccggaga aacggtggaa acaaagcctg tcaatcacga 1551541 cattgataaa gcggatgtag aaaaggtttt aaacagttta aaggggaaac aagaacaaat 1551601 tccgcccatg tattccgctg taaaagtaaa cggcaaaaaa ttatacgaat acgcaagagc 1551661 agggattgaa gtagaacgtc cgaaacgtat gataaccatt gaagacattg ccctgacaac 1551721 agagattaaa catcatggag aaaccgcaag cttccggttt acagtgactt gctccaaagg 1551781 gacctatgta aggacgctgg cggtcatgat cggagaaaag ctcggatatc cggcccatat 1551841 gtctcattta atccgtacgg catccggaga tttttctctc gacgaatgct ttacttttga 1551901 tgaactcgaa gcacaggccc aatccggaac cgtggaagag catacagttc ctattgaacg 1551961 tgcgctcaat catttgccga aatggatcat aagtgataca ttagctaaga aagtagaaaa 1552021 tggggctttg cttgagacgc ccgagcagtt ttctgaaatg acaagtggag accgtattgc 1552081 cgtctttact gaatccggaa cctgcttggc gatctatttc cctcatcctg caaaaaaagg 1552141 gctgttaaag ccggcaaaag tattgatgca aaaaagcgaa caatagaaaa aaggtgaccg 1552201 ttctgtgaag acgatacata ttacacatcc tcatcattta ataaaagagg agcaggcaaa 1552261 atcagtgatg gcgttaggtt attttgacgg cgttcatctc gggcatcaaa aggtaatcgg 1552321 cacagcgaag caaatagccg aagaaaaagg tctgacatta gctgtgatga cctttcatcc 1552381 ccatccttct cacgtgttgg gcagagataa ggaaccaaag gatctgatta cgcctcttga 1552441 agacaaaata aaccaaattg aacaattagg cacagaagtt ctgtatgtcg ttaaatttaa 1552501 tgaagtgttt gcttctcttt ctcctaagca gtttatagac cagtatatta tcggccttaa 1552561 tgtgcagcac gcagtggcag gctttgactt tacgtacggc aaatacggca agggaacaat 1552621 gaagaccatg ccggatgatt tagacggaaa agctgggtgc acaatggtag aaaaattaac 1552681 ggagcaggat aaaaaaatca gttcttcgta tatccgtacc gcgcttcaaa acggagatgt 1552741 tgaattggcg aatgtcttgc ttggacaacc ttattttatt aaaggaattg tcattcatgg 1552801 tgataaaaga gggcggacca tcgggtttcc gacagcgaat gtcggtttaa ataacagcta 1552861 tatcgttccg cccacaggtg tatatgccgt aaaagcggaa gtgaacggcg aagtttacaa 1552921 tggcgtttgc aatattggct ataagccaac gttttatgaa aagcgccctg aacagccttc 1552981 catcgaggtc aatctgtttg atttcaatca agaggtatat ggagccgcta taaaaatcga 1553041 atggtacaaa cggattcgga gcgagcggaa attcaatggc atcaaagaat taactgagca 1553101 aattgagaaa gataagcagg aagccatccg ttatttcagc aatttgcgga aataacttgc 1553161 aacgcacgca aattttattc taaaatattt gcatataggc acgattttta gtatgatagt 1553221 tttcgtagtc ttaaaaccat tgcttggcaa tccgaagtca ccgacggttg ctaggtaact 1553281 ggggctaaat atgatttgga ggtgaaacag gatggcaatt actcaagagc gtaaaaacca 1553341 actcatcaat gagttcaaaa cacacgaatc tgatactgga tctccagaag ttcagatcgc 1553401 tatcctaact gactcaatta acaacttgaa cgagcattta cgtactcaca agaaagacca 1553461 ccactcacgt cgcggtcttc ttaaaatggt aggtaagcgt cgtaatcttc ttacgtatct 1553521 gcgtaataaa gacgtaactc gttaccgtga gttaattaac aaactaggct tacgtcgata 1553581 atcgtaaaaa gcgggaggat tcccgctttt ttatcgtatt aaagcgaaat ttcttataac 1553641 aaatcattga aatcctttta catactactt tgacattgat atgttcaatt catttcgttc 1553701 ataataggag taattgatta tttcacacaa cgaagagagg agttcgtaat tgtatgggac 1553761 aagaaaaaca tgtctttacc atagattggg ccggaagaac gcttaccgtt gaaaccggcc 1553821 agcttgccaa acaggcaaat ggtgctgtga tgatccgcta cggtgataca gcagtactta 1553881 gtacagcaac cgcttcaaaa gaacctaaac cgcttgattt cttccctctt actgtaaact 1553941 atgaagaaag attatatgcg gtagggaaaa ttccgggcgg atttattaaa agagaaggac 1554001 gtccaagtga aaaagcggtt cttgccagcc gtttaattga ccgtccgatc cgtcctttgt 1554061 ttgccgatgg attccgtaat gaagttcaag tcatcagcat tgtcatgagt gttgaccaaa 1554121 actgctcttc agaaatggct gccatgttcg gttcatctct tgcactttct gtatcggata 1554181 ttccgtttga aggaccgatt gcaggggtta ctgtcggacg cattgatgat caatttatca 1554241 ttaacccgac agtcgatcag cttgaaaaaa gcgatatcaa tcttgtcgtt gccggcacga 1554301 aagatgcgat taacatggta gaagcgggag cggacgaagt tcctgaggaa atcatgcttg 1554361 aggccattat gttcggccat gaagagatta aacgcctgat tgcattccaa gaagaaattg 1554421 ttgcagcagt cggcaaagag aaatctgaaa ttaagctctt tgaaattgat gaagagctta 1554481 atgaaaaagt aaaagctttg gcagaagagg atctgctgaa agccatccaa gttcatgaaa 1554541 agcatgcccg tgaagatgcc attaacgaag tgaagaacgc agttgtggca aaattcgagg 1554601 atgaagaaca tgatgaagac acaatcaagc aagtgaagca gattttatcc aagcttgtga 1554661 aaaatgaagt tcgccgcctg attactgaag agaaagtaag accggacggc cgcggtgtcg 1554721 atcaaatccg tccgctctct tcagaggttg gcctcttgcc aagaacgcac ggttcaggtc 1554781 tatttacaag gggacaaact caggccctca gcgtatgtac gctaggtgct ctgggagatg 1554841 tgcaaatcct tgacggctta ggtgtcgaag agtcgaaacg gtttatgcat cattacaact 1554901 tcccgcaatt cagcgttggg gaaacaggac cgatgcgcgg accgggacgt cgtgaaatcg 1554961 gacacggagc actgggtgag cgtgcgcttg agccagttat tccgtctgaa aaagacttcc 1555021 cttatactgt ccgtcttgtt tcagaagtgc ttgaatcaaa cggttctaca tctcaagcaa 1555081 gcatttgcgc aagcacactt gcaatgatgg atgccggtgt accgattaaa gcgccagttg 1555141 ctggtattgc gatgggtctt gtcaaatcag gcgaacatta cactgtcttg actgacatcc 1555201 aaggcatgga agacgcgctc ggagatatgg actttaaagt agcgggaact gaaaaaggcg 1555261 taacggccct gcaaatggac attaaaattg aaggcctttc cagagagatt cttgaagaag 1555321 cgcttcagca ggcgaaaaag ggcagaatgg aaatcctcaa cagcatgctt gcaacattaa 1555381 gcgaatcaag aaaagagctt tctcgatatg cgcctaagat cttaacaatg accattaatc 1555441 ctgataaaat ccgcgatgtc atcggaccaa gcgggaaaca aatcaataag atcatcgaag 1555501 aaaccggtgt taaaattgat attgagcagg acggcacaat ctttatttcc tctacagatg 1555561 aaagcggcaa ccaaaaagcg aaaaaaatca tcgaagacct tgtgagagag gttgaagtcg 1555621 gccaacttta cctaggtaaa gtgaaacgga ttgaaaaatt cggggctttc gttgaaattt 1555681 tcagcggaaa agacggtttg gtgcacattt cagagcttgc gcttgaacgc gtagggaaag 1555741 ttgaagatgt tgtgaaaatc ggagacgaga ttcttgtcaa agtcactgaa attgataaac 1555801 aaggacgagt gaatttatcc cgcaaagcgg tgctccgtga agagaaagaa aaagaagaac 1555861 aacaatctta aatgaaaaca taaaaggagc ctgggagacc cggcttcttt attttgaagc 1555921 ttttcaaaag caggcgggtt ctaccttgtc cttctccttc ataatgtgag gtgagggggg 1555981 gacagaacat gtacaaaaaa tttgtaccgt ttgccgtttt tttatttctt ttttttgtct 1556041 catttgagat gatggaaaat ccgcatgcac ttgattatat aggggcaatg aaaaaagata 1556101 cggtgactgt cacggcgtca aaagacccgt tatatgaaga attgcttcaa aaagcgccgg 1556161 agtacgaagt taagccccag aatgcaagaa ttgataaagt gtggaaaagc attccaggct 1556221 acaatggatt aaaggtcaat attgaacaat catataaaaa aatgaaacag catggtaagt 1556281 ttcgggaaaa agatttggtg tacagtcaag taaaaccaag tgttcatctt gagtcacttc 1556341 agcctgagcc tatttataaa ggaaatcctg acaaaccgat ggtggctttt ttaatcaatg 1556401 tggcatgggg aaatgagtat ttggaaaaaa tgcttcctat tctgcaaaag caccaggtta 1556461 aagctacgtt ctttttagaa ggcaattggg tgagaaacaa tgtacagctc gctaagaaga 1556521 ttgcaaaaga cggacatgaa atcggaaatc attcatacaa tcatccggat atgagcaaac 1556581 tgactacagg aagaatttcc gagcagctcg acaagactaa tgaacaaata gaacaaacga 1556641 tcggcgttaa gccaaagtgg ttcgctccgc caagcggaag tttcagaaaa gcggttatcg 1556701 acattgcagc agagaaacag atgggaacag tcatgtggac agttgataca atcgattggc 1556761 aaaagccggc tccgtctgta cttcagacga gagtgttaag caagatacat aatggtgcca 1556821 tgattttaat gcatccgact gaccctacgg cggaaagtct tgaagcgctg attacacaga 1556881 taaaagacaa aggatatgcg cttggaacag tcactgaact aatggatgaa acaagactat 1556941 tgaagtaaca gatgaaggca gcttgtcttt gaataggagg aacaaatttg attaaacgat 1557001 atacgtgtca aaatggtgta agaattgtgc tggaaaataa cccgacagtc cgttctgttg 1557061 cgatcggcgt atggatcggc acaggttcga gacatgaaac gccggagata aacggaattt 1557121 ctcacttttt agagcacatg ttctttaaag ggacgagcac aaaatctgca cgcgagatag 1557181 cagaatcttt tgatcgtatt ggcggccagg tcaatgcgtt tacttcaaag gaatatacct 1557241 gctactatgc aaaggtgctt gacgagcatg cgaattacgc gctggacgta ttagcagata 1557301 tgttctttca ttcaacgttt gatgaaaacg agctgaaaaa agagaaaaat gtagtatatg 1557361 aagaaattaa aatgtatgaa gatgcgccgg acgacattgt acatgattta ttgagcaaag 1557421 ccacttacgg caatcattct ttaggctacc caattttagg aacggaagaa acgcttgctt 1557481 cctttaacgg tgactctctc agacaataca tgcatgatta ttatacgccg gaccgagtgg 1557541 tgatttcggt agcgggcaat atatctgaca gttttatcaa agatgtagaa aaatggttcg 1557601 ggtcatacga ggcgaaaggc aaagcgacag gccttgagaa gcctgagttc cacacggaaa 1557661 aactgacgag aaaaaaagaa acagagcagg ctcatttgtg ccttggattt aaaggcttag 1557721 aggttggcca tgaacgtatt tatgatttaa tcgtcctcaa caatgtgctc ggaggcagca 1557781 tgagcagccg gctgttccaa gatgtgcgtg aagataaagg acttgcttat tctgtttaca 1557841 gctatcacag ctcatatgag gacagcggaa tgctaacgat ttacggcgga acgggtgcaa 1557901 atcagcttca gcagctgtcg gaaacaattc aagaaaccct ggccacatta aaacgtgacg 1557961 gcattacctc gaaagaactg gaaaacagca aagagcaaat gaagggaagc ttaatgctga 1558021 gcttagaaag cacaaacagc aaaatgagcc gaaacggaaa aaatgaactg ctgctcggca 1558081 aacataaaac attagatgaa attatcaatg aattaaacgc cgtgaactta gagcgtgtta 1558141 atggccttgc cagacaattg tttaccgaag actatgcatt agcacttatc agcccttccg 1558201 gcaatatgcc gtcttaaaaa ggaaagcctg ccccataatg gagcaggcat tttttaatcc 1558261 ctttcatcat acatagtaca agggggtgac agacatgcgg ctcagtgaat tatcgggaaa 1558321 ggaaattgta gacatcaaaa gagctgaacg gctcggagtg ctcggccaga ccgatttgga 1558381 aatcaatgaa caggatggac agattacagc actcctcatt cccacagtta agtggtttgg 1558441 tttgagaaag caaggtcatg acattcgtgt cccatggcac catattcaaa agatcggttc 1558501 agatatgatt atattagatg tacctgagga aatgcctcct cgacaagagt aaatagccca 1558561 attgactgtg aagcgggctc taaagaaaac atctgaaaca tcggctgccg gagccgatgt 1558621 ttttttatat ggaaaaagcg catcttttat attcaccggt atttcctttt gatcataaga 1558681 tgaaggggag cttaacaact agagatccag tatatacaaa gaaggtgaac gtttagaatg 1558741 ttaaccggat tgaaaattgc agttatcggc ggtgacgcaa gacagctcga aattataaga 1558801 aagctcactg aacagcaggc tgacatctat cttgtcggtt ttgaccaatt ggatcacggt 1558861 tttaccgggg cagtaaaatg caatattgat gaaattcctt ttcagcaaat agacagcatc 1558921 attcttccag tatccgcgac aacaggagaa ggtgtcgtat cgactgtatt ttcgaatgaa 1558981 gaagttgtgt taaaacagga ccatcttgac agaacgcctg cacattgtgt cattttctca 1559041 ggaatttcta acgcctattt agaaaacatt gcagctcagg caaaaagaaa acttgttaag 1559101 ctgtttgagc gggatgacat tgcgatatac aactctattc cgacagtaga aggaacgatc 1559161 atgctggcta ttcagcacac ggattatacg atacacggat cacaggtggc cgttctcggt 1559221 ctggggcgca ccgggatgac gattgcccgt acatttgccg cgctcggggc gaatgtaaaa 1559281 gtgggggcaa gaagttcagc gcatctggca cgtatcactg aaatggggct cgttcctttt 1559341 cataccgatg agctgaaaga gcatgtaaaa gatatagata tttgcattaa taccataccg 1559401 agtatgattt taaatcaaac ggtactttct agcatgacac caaaaacctt aatattggat 1559461 ctggcctcac gtcccggggg aacggatttt aaatatgccg agaaacaagg gattaaagca 1559521 cttcttgctc ccgggcttcc agggattgtc gctcctaaaa cagctgggca aatccttgca 1559581 aacgtcttga gcaagctttt ggctgaaata caagctgagg aggggaaata aggatgtcgt 1559641 cattaaaagg aaaaagaatc gggtttgggc tgaccgggtc gcattgcaca tatgaagcgg 1559701 ttttcccgca aattgaggag ttggtcaacg aaggagctga agtccgtccg gttgtcacat 1559761 ttaatgtaaa atctacaaat acccgatttg gagagggcgc agaatgggtt aaaaaaattg 1559821 aagacctgac tggatatgag gccattgatt cgattgtaaa ggcagaacct cttgggccga 1559881 agctgcccct tgactgcatg gtcattgcgc ctttaacagg caattcaatg agcaagctgg 1559941 caaatgccat gacggacagc ccggtgctga tggcggcaaa agcgacaatc cggaacaatc 1560001 ggcctgtcgt tctgggtatc tcgacaaatg atgctcttgg tttaaacgga acaaatttaa 1560061 tgaggctcat gtcaacaaaa aatatctttt ttattccatt cgggcaagat gatccattta 1560121 aaaaaccgaa ttcaatggta gccaaaatgg atctgcttcc gcaaacgatt gaaaaggcac 1560181 tcatgcacca gcagcttcag ccgattctag ttgagaatta tcagggaaat gactaaattt 1560241 acagaaaatc tttcccaaac taaaaaattc ggtcatcacc cgcatattct atggtaaaat 1560301 aaaacgtaaa atcatagtca aatcaattca atgaagctga ttggcggaag gagttttaca 1560361 gatgggaaga ggtttacacg tagctgttgt cggagcgaca ggggctgtgg gacaacaaat 1560421 gcttaaaaca cttgaagaca gaaactttga aatggacaca cttacattgc tatcttcaaa 1560481 acgctctgcg gggacaaaag tcacgtttaa aggccaagag ctgactgttc aggaagcttc 1560541 tcctgagagc tttgaagggg taaatattgc tttgttcagc gccggcggaa gcgtatcaca 1560601 agcattggca ccagaagctg taaaacgcgg cgctattgtt atagataata cgagtgcgtt 1560661 ccgcatggat gaaaatacac cgcttgttgt gccagaagtg aatgaggcag acttgcatga 1560721 acacaacggc attattgcca atccaaactg ctctacaatc caaatggttg cggcacttga 1560781 accgatccgc aaagcatatg gcttaaacaa ggtcatcgta tcaacttacc aggcagtatc 1560841 aggagcgggt aatgaagctg taaaagagct ttacagccaa acacaggcga ttttaaataa 1560901 agaagaaata gagcctgaga tcatgcctgt aaaaggtgac aaaaaacact atcaaatcgc 1560961 cttcaacgcg attccgcaaa tcgataaatt ccaagataac ggctatacgt ttgaggaaat 1561021 gaaaatgata aatgaaacga aaaaaatcat gcacatgcct gaccttcaag tagcggctac 1561081 atgtgtgaga ctgccaatcc aaactgggca ctcagagtcc gtctacatcg aaatagaccg 1561141 tgatgacgct acagttgaag atattaaaaa tctattgaaa gaagctccgg gcgtgacact 1561201 tcaggatgat ccaagccagc agctttatcc gatgcctgct gatgctgtcg gcaaaaacga 1561261 tgtgtttgta ggccgcatcc gcaaagactt ggacagagca aacggttttc atttatgggt 1561321 tgtttctgat aacctattaa aaggcgcggc atggaactct gttcaaattg cagaaagcct 1561381 gaaaaaacta aacctcgtat aaaagagaga attttctaaa gacgaataga agagagtaag 1561441 gcgctatcag cctgctctct tctgttacgt ccgaataatt tggagtgaaa acagtgaaga 1561501 taattgttca aaagttcggc ggaacatcag taaaagatga taaaggccgc aaactggctt 1561561 tagggcatat taaagaagca atcagtgaag gatataaggt tgtcgttgtc gtttcagcga 1561621 tgggccgaaa aggggacccg tatgcaacag attctttgct cgggctgctt tacggcgatc 1561681 agtcagcgat ttctcctagg gagcaggatt tgcttttatc ttgcggagag actatttcct 1561741 ctgtcgtctt tacaagcatg ctgcttgata acggtgtgaa agcagctgcg ctgacagggg 1561801 ctcaggctgg ctttttaacg aatgatcagc atactaatgc gaaaatcatt gaaatgaaac 1561861 cggagcgttt attcagtgtg ctcgccaatc atgatgcggt agtcgtcgca ggcttccagg 1561921 gcgcaactga aaagggtgat acaacaacaa tcggcagagg gggcagcgat acgtctgcag 1561981 ccgcactcgg agcagctgtt gatgcggaat acatcgatat tttcaccgat gtagaaggcg 1562041 tgatgactgc tgacccaaga gtggtagaaa atgcaaaacc gcttcctgtt gtgacgtata 1562101 cggaaatctg caacctggcg tatcaggggg ccaaggtcat ttctccgcgt gctgtggaaa 1562161 tcgcaatgca ggccaaggtt ccgatccgcg tccgttcgac ttattcgaat gataaaggca 1562221 cattggtgac atcacatcac tcttccaagg tcggcagtga tgtttttgaa aggctgatta 1562281 cgggaatcgc ccatgtcaaa gatgtcacgc agttcaaagt gcctgcgaaa atcggccagt 1562341 ataacgttca gactgaagtg ttcaaggcta tggcaaacgc tggaatcagt gtcgatttct 1562401 ttaacattac acctagtgaa atcgtctata cggtagccgg aaataaaaca gaaacagctc 1562461 agcgtatttt aatggatatg ggctatgatc caatggtgac gagaaactgc gcgaaggtat 1562521 cggcggtcgg cgcgggcatt atgggtgttc ccggtgttac gtccaaaatt gtatcggctc 1562581 tttcagaaaa agaaattccg atccttcagt cggctgacag ccatacgacg atatgggtgc 1562641 tcgtccatga agcggatatg gttcctgctg taaacgcttt gcatgaagtg tttgaacttt 1562701 cgaagtaaat gtgattgaat catgatgagg tgaataaaat gaatttcgga aatgtgtcta 1562761 cagcgatgat tacacccttt gacaataaag ggaacgtaga ctttcaaaaa ctgtctacac 1562821 tgattgatta cttgttgaaa aacggaacgg attctttagt agtagcggga acaactggag 1562881 aatctccgac cctttcaact gaagaaaaaa ttgcgctttt tgaatatacg gtaaaagaag 1562941 taaacggacg ggtgcccgtt atcgctggta ctgggagcaa caacacgaaa gattccatta 1563001 agctgacaaa aaaagctgag gaagcgggcg tggacgctgt tatgcttgtt accccgtatt 1563061 acaataaacc ttctcaagaa ggaatgtacc agcattttaa agcaattgcg gcagagacat 1563121 ctcttccggt tatgctctat aatgttcctg gccgtacggt tgcttctctt gctcctgaaa 1563181 cgacgatccg tttggcggca gacattccga atgtggttgc gattaaagaa gcgagcggag 1563241 acctcgaagc gattacaaaa attattgctg aaacacctga agacttctat gtctattcag 1563301 gggatgatgc tctaacgctt ccaattcttt cagttggagg tagaggagtt gtgtcagtgg 1563361 cgagccatat tgcaggcact gatatgcagc aaatgatcaa aaattatacg aatgggcaaa 1563421 cagctaatgc ggcactgatt catcagaaac tgctgccgat tatgaaggaa ctgtttaaag 1563481 cgcctaatcc tgctccagtc aaaacagcgc ttcagctgag aggtcttgat gtcggttctg 1563541 tgcgtctgcc tctagtccca ttaactgagg atgaacgtct gagcttaagc agcacgatca 1563601 gcgaactgta agaaaatttc atacagtgaa acaaacgcgg tcattctcac attcagctga 1563661 gtttgaccgt ttcttttaca tattggtttt ccctaaacct tctgctttat cttgttttct 1563721 aaatttactt tcagttataa taggaacaag tgatgatgga cgggtatgag actaggagga 1563781 tatagatttt gaaaaagaaa aatacagaaa acgttagaat tatcgccctt ggcggtgtcg 1563841 gagagattgg gaagaacctt tatgtcattg aaattgactc agacatattt gtcgttgatg 1563901 ccggccttat gcatccagaa aacgaaatgc tcggtattga tgtagtgatt cctgacatat 1563961 catatttgat tgaacgggct gaccgcgtca aggcaatctt tttaacgcac gggcacgatg 1564021 aaaatatcgg cggcgttttt tacttattaa acaagctgtc cgttccagtg tacggaacaa 1564081 aactgacgct tgcactgtta agagagaaat taaaacaata cggacataac cgaaaaactg 1564141 atttaagaga aattcactcc aaatctgtca ttacatttga atcaacaaag gtatcgttct 1564201 ttagaacgat tcacagcatt cctgattctg taggtgtgag ctttaaaaca tcacttggat 1564261 ctattgtatg cacgggagac ttcaaatttg accaaacacc tgcacttaat cagacgtgcg 1564321 acattggcga gatcgccaag atcggcaata gcggcgtgct cgctctgctt tctgacagtg 1564381 caaatgcgga acggccgggt tacacccctt cggaagcggc tgtcagcgga gaaatttcgg 1564441 atgcgctgta taattcacag aaccgggtga ttattgctgt tttcgcatcc aatattaacc 1564501 ggattcagca agtcattcat gcagcggctc aaaatggcag aaagattgcc gtagccggaa 1564561 aaaatcttca atctgtcctg cagctggcga gaaagttagg atatattgaa gcagatgatg 1564621 aattgtttat ttctgtacag gatgtcaaaa aatatccgaa gcgcgaagtg gccattatta 1564681 cagccggaag ccaaggtgaa ccattagctg ctttgacaag aatggcaaac aaagctcaca 1564741 aacagctgaa cattgaagaa ggggatacgg tggtcattgc gtcaactccg attcccgggc 1564801 aggaactcat ttactctaaa acagtagatc ttcttgcgag agccggtgca caagtcatct 1564861 ttgcccaaaa gcgtgttcat gtatcaggcc acggctcaca agaagagtta aagctgatga 1564921 tcaacctgct taaaccaaaa tatttgattc ctgtaaacgg cgaatacaga atgcaaaaag 1564981 ctcattcaaa aatcgctgaa gaaaccggca tgaagcgcag tgacatcttc ttaattgaaa 1565041 aaggcgacgt cgttgaattc cgcggccaaa acgtaaaaat tggggataaa gttccttacg 1565101 gcaatatttt aattgatggt ttaggtgtcg gtgatatcgg caatatcgta ttgagagacc 1565161 gccgcttgct ttcacaggac ggaattttaa tcgttgtcat tacacttgat aaacaaaaga 1565221 aacatcttgt atcaggacca gaaattatca ctcgcggctt tgtttatgta agagagtctg 1565281 aaggtcttat cgtacaggct actgagcttg tacggtccat cgtgacagaa gcgactgaaa 1565341 catcaaatgt cgaatggtca acgctgaagc aggcaatgcg ggatgctttg aaccaattcc 1565401 tttatgaaaa aacgaaacgt aaaccgatga tcatcccaat tattatggaa gtataatgac 1565461 tgactaaaga ccggagctgc tccggtcttt attttttgtc cttcaagccg ggattgaatg 1565521 aagtatcttt gttcataata caaagagaaa ctcggaaagg atgaaagcga gatggatcat 1565581 cgtatggaaa acacagaaga agagcgtcct gaaaaaaatg atgcgaagga cagcattatg 1565641 aataaaatac agcagcttgg tgaaacgacg cttccgcagc tgccccaaga tacaaatatt 1565701 cattgtctga ccattatcgg acaaattgaa ggccatgttc agcttcctcc gcaaaacaaa 1565761 acaacaaaat atgaacatgt catcccgcag attgtggcaa ttgaacaaaa tcccaaaatt 1565821 gaaggcttgc tgatcatatt aaatactgtc ggaggagatg ttgaagctgg tcttgccata 1565881 gcggaaatgc ttgcatcttt atcgaaaccg accgtttcta tcgtgcttgg cggggggcat 1565941 tcaatcggcg ttccgattgc tgtatcctgt gattacagct atatcgccga aacagcaacg 1566001 atgacgattc atccagttag gctcaccggg ctggtcatcg gggtgccgca aacgtttgaa 1566061 tacctggata agatgcaaga aagagttgtt aaatttgtga caagccattc caatataacc 1566121 gaagagaagt ttaaagagct aatgttttca aaaggaaact taacacgcga tatcggaaca 1566181 aatgtagtcg gtaaggatgc agttaaatac ggattgatcg atcacgcagg cggtgtcgga 1566241 caggcaatca ataaactgaa tgagctcatc gatgaagcaa ggaaagaaga aggacggatg 1566301 attcaatgat tctttatacc gtgatgcctc aggaaattgt gtttgcagaa cagaaccaag 1566361 agacaagcgc acatgagcaa attgaatata aaggtgtacc gcttctagtc gaaatgaaag 1566421 ggaatgaagc ggaagtcatt caaatcatga gcaccaatcc aatgcatttt ctgcatccgg 1566481 acatttcacc gggacaaaag ctgaaattaa acgtataaga atccaaccct tttttaaggg 1566541 caaaatatgc tataataggg gaatcctaca gaaaaaacgc agcctgtaaa cggctgcttt 1566601 cttcattatg tatgaactta cattttttaa cgcagtaagg tgatgagtgt ggcaaagaaa 1566661 aaacgaaaat caagaaaaaa acaggcgaaa cagctcaata taaaatacga gctcaacgga 1566721 ttgctgtgta tagccatttc aattatcgca atcttgcagc tgggggtagt cgggcaaacg 1566781 tttatctatt tgttccgctt ttttgctgga gagtggttta ttttatgctt gttaggttta 1566841 ttggtgttag gagtctcact gttttggaag aaaaaaaccc caagcctttt aacgagacga 1566901 aaggccgggt tgtactgtat tatcgcaagc atattgctgc tttctcacgt gcagctattt 1566961 aaaaatttga cgcacaaagg gtctattgag tctgcaagcg tggtgcgcaa tacgtgggaa 1567021 ttgtttttaa tggacatgaa tggcagctct gcttcacctg atttaggcgg agggatgatc 1567081 ggtgcgctgc tgtttgcggc ttcacacttt ttgtttgcgt cgactggttc tcagatcatg 1567141 gcaattgtca tgattttgat cggaatgatt ttagtaacag gacgctcgct gcaagaaacg 1567201 ctaaaaaagt ggatgagccc gattggacgt tttataaaag aacaatggtt agcatttatt 1567261 gatgacatga aatccttcaa atcaaatatg cagtcatcga aaaaaacgaa agcgccgagc 1567321 aaaaaacaaa aaccggcccg caaaaaacag caaatggaac cggagcctcc tgatgaagag 1567381 ggggattatg aaacagtatc gcctcttatt cattcagagc cgattatctc aagcttttct 1567441 gatcgtaatg aagaggaaga gtctccagtt atagaaaagc gcgccgaacc tgtgtcgaag 1567501 ccgcttcagg acatccaacc ggagacaggt gatcaggaaa ctgtttctgc tcctcctatg 1567561 acctttacag agctcgaaaa taaggattac gagatgccgt cactggattt gctggcagat 1567621 ccgaagcata ccggccagca ggctgataaa aagaatattt atgaaaatgc gagaaagctt 1567681 gaacgcacat tccaaagctt tggcgtaaag gcgaaagtca cacaggttca tctcggaccg 1567741 gccgtaacaa aatatgaagt atatcctgat gtcggagtga aggttagcaa aattgtcaat 1567801 ttaagcgatg atttagcgct tgcgcttgct gcgaaggata tcaggatcga agcgcctata 1567861 ccaggcaaat cagcaatcgg aattgaagtt ccaaacgcag aagtggcaat ggtttcgctg 1567921 aaagaagtgc tggagtctaa attgaatgac agaccggatg cgaagctgtt aattggactc 1567981 ggccgcaata tttcaggtga agctgtattg gctgagttaa acaagatgcc ccaccttttg 1568041 gtcgcaggcg caaccggtag cgggaaaagt gtctgtgtca acggcattat tacaagtatt 1568101 ttaatgcggg cgaaaccgca tgaagtgaaa atgatgatga tcgatcctaa aatggtagag 1568161 ctaaatgtct acaacgggat tccgcatttg cttgctcctg ttgtaaccga tccgaaaaaa 1568221 gcgtcgcagg ctttgaaaaa ggttgtcaat gaaatggagc ggcggtacga attattttct 1568281 catacgggta caagaaatat tgaaggatac aatgattata taaaacgcgc caacaatgaa 1568341 gaaggagcga aacagccaga gctgccttat attgttgtca ttgtggacga gctagccgat 1568401 ctcatgatgg tcgcttcatc tgatgtggaa gattcgatta cgagattgtc ccaaatggcg 1568461 cgggctgccg gcatccatct tattattgcg acacagcggc catcggtgga tgttatcaca 1568521 ggggtgatca aagcgaacat tccgtcacga atcgcgttca gcgtatcttc acagacggat 1568581 tcaaggacca ttcttgacat gggtggcgct gagaagcttc ttggccgcgg cgatatgctg 1568641 tttttacctg taggggctaa caaacctgtc cgtgtgcagg gagcattttt gtcggatgac 1568701 gaagtggaga aggtcgtcga ccatgtgatt actcagcaga aagcgcaata tcaagaagaa 1568761 atgattcctg aggagacgac ggaaactcat tccgaggtta ctgatgaact ttatgatgaa 1568821 gctgttgaat taatcgtcgg catgcagacg gcatctgttt caatgctgca aagaagattc 1568881 agaattggct atacgagagc ggcgcgcctg attgacgcaa tggaggaacg cggtgttgtc 1568941 ggaccgtatg aaggcagcaa acctagggaa gtattattat caaaagagaa atatgatgag 1569001 ctctcttctt aatgaaggga gttccgcttt ctatagttgt caataatgat attatgtaaa 1569061 ctgatcacct ttctatttat tttttcgaca aaacatgata tagttgtccc aattgttcaa 1569121 taatttttat cgaaagtggt ttacggaggg gaaacatgtc tacaaaagct gataatcggc 1569181 acttgtattt gaaagtaatt gaacgaatta aagaggatat aaaaaatggg atctacactg 1569241 agaaggaaaa gctgccttct gaatttgagc tttccaaaaa gcttggtgtc agcagagcga 1569301 cgctaagaga agccttgcgg atactggaag aagagcatgt gattatcaga aggcatggtg 1569361 taggcacttt tgtccattct aagccgttat ttctttcggg tattgaacag ctgaacagtg 1569421 taaccaagat gatagaacag gcgaatatga cccctggcac gatttttcta tcatcacaag 1569481 tgcttatgcc gtctgaagat gatacgaaga gatttcactt ggcagaaggg caagaacttt 1569541 tttaccttga acgagtcagg acagctgacg gacagccgat tgtgtattgt atagacaaaa 1569601 ttccgatgaa tattttgccg aattcttttt ctcatcagca agaatctatg tttgacctgc 1569661 tagagaaaaa ttcaggctcc gtaatcagct atgcagtaac tgatatagaa ccgatcggct 1569721 atcacgatac catttctcca gtgcttgaat gcgatccgga aacagctctt ttgctgttaa 1569781 aacaaaccca ttacgatcag cacgataaac cggtgcttta ttctttaaat tattttagag 1569841 cggataaatt cagatttcat gttttgcgta aacgattcta aaaacggacg cctgtatgtg 1569901 tctgtttttt tatttgcact gattcatgtt tctttgtaca tactttcatt ccggttaacg 1569961 caatatataa gggatgacaa gaaagtgaat gggtgaaaat gttgagagag aaaaatggaa 1570021 tgaaaaatat tattgcattg tcttctgtcc cgcttgtgat gacactcggg aactccatgc 1570081 tgattcctgt tcttccgatg atggagaaaa agctgtctgt gacttcattt caagtatctt 1570141 taatcattac tgtatattca gtagtagcaa ttatttgcat tccgattgcc ggatatttgt 1570201 cggatcgttt cgggagaaaa aaaatattgc ttccatgcct cctcattgca ggattggggg 1570261 gagccgtagc tgcttttgcc tcgacctata tgaaaaatcc ttatgctatg atcttggcgg 1570321 ggcgggttct tcaaggcatt ggttctgcag gtgccgctcc gattgtcatg ccgtttatcg 1570381 gcgacctgtt taaaggagac gatgaaaagg tcagcgcggg tcttggcgat attgaaaccg 1570441 ccaacacgtc agggaaggta ctgagtccca tacttggagc cttactggct tcttggtatt 1570501 ggtttgtacc gttttggttt attccgtttt tctgtttgat cagctttttg ctcgtattgt 1570561 ttttggtggc caagcctgaa gaagatgaag atgcgcctgc tgtttctgag tttattaaga 1570621 gtgtgaagaa aatttttaaa caggatggtc gctggcttta tacggtcttc attatcgggt 1570681 gtgtcattat gtttttgtta tttggcgtat tattttattt atcagatacg ctggagaaca 1570741 agtatgctat tgacggagta gctaaaggcg gattactggc aatcccactt ttgtttttgt 1570801 caaccagttc ttttatagct ggcaaaaaga tcggtaaaga taaaggccga atgaaatttt 1570861 gcgttgttac aggaatgatt ctgttaaccc tttcgtttat tgccttgtgg tggaaccaca 1570921 gtttttattt tttatttgtc tttttaagct ttggcgggat tgggattgga atggctcttc 1570981 ctgctttaga tgcattgata accgaaggga ttgaaagtga acaatgcgga accatttcct 1571041 ccttttacaa tagcatgcgc tttataggag tagctctcgg tccacctgtt tttgctgcat 1571101 taatgtctaa tgcaaactgg attattttca tactctcggc gttttgcagc atcgtttctt 1571161 tatttttagt gctctttact gtagatgcta aaaaaagtga agaagaaaaa aacttaggga 1571221 cggtctagcc agccgtcttt ttttgcgctt tcttgcacag tttacaactg tacctataca 1571281 gcatgcggag gttattgttt ccttataaat cctacagttg ctataattac atgaaagagt 1571341 gtttctgcgg atgctgaaaa ttggtcataa tacatactaa ttaagaaatg aacgaaggag 1571401 gttccatatg tcatatgtta atgaactcaa atcaaagcac ggcggtttaa ccgcacacat 1571461 tgtaaaaaca gaaaaattca aaaccgtctc gcttattttt aagatgcttg cgccgctgac 1571521 aaaggatcaa gtcaccaaaa gagcgcttct cccgcatgtg cttcttcgcg gaacgaaaag 1571581 ccatccgaaa accgcaggat tgcgttcata cttggatgag ctgtacggca cgtcagtatc 1571641 ggctgatctt acgaaaaaag gagagcggca tgtcattacg ttcaggcttg aaatcccgaa 1571701 tgaaaaatat ttaaaagacc aaacgccgct tctcgagaaa gggctccagc ttctcgcaga 1571761 actcgtcttt tcacctgctt tggagggaga cgcttttcag tcacaatatg tggctcaaga 1571821 aaaacggacg cttaagcaaa gaatccaagc cgtctatgat gataaaatgc gttattcgaa 1571881 tttaaggctg atacaggaaa tgtgcaaaaa tgatccttac gcgcttcatg tcaatggtga 1571941 aatcgacgat gtcgatgaca ttacggcaga gcaattatac gaaacatacc aaagcgctat 1572001 ccaaaaagac cagcttgatc tatatgttgt tggcgacgtg gacagtaacc aggtacaatc 1572061 ggcaattgat aagtatttca aaacagaaga gcgcactctt ggcatgattg aaaacaatca 1572121 cgctgatgaa aaagttcagc caaaagaagt aattgatgaa gaggatgtca agcaaggaaa 1572181 actgaatatc ggctaccgca ccagcatcac ttatacagat caggattatc ctgctttaca 1572241 agtgtttaac ggattgttcg gcggattctc tcattctaaa cttttcatta atgttcggga 1572301 aaaagccagt cttgcttact acgcggcttc gcgtatagaa agttttaaag gcttgttaat 1572361 ggtgatgtca ggcattgaag tgaaaaattt tgaacaggcg gtttcgatta ttgctgagca 1572421 attccaggca atgaaaaatg gcgatttcag tgagcaggat atagcacaga caaaggccgt 1572481 tattcgaaat caagtgctgg aaacgattga tacagcatac ggtttatctg agtttttata 1572541 tcagcaggcc gctgctcaag tcgagattcc tatcgaagac tttcttgcca atattgagaa 1572601 tgtcacaaaa gaggatatca ttaaagccgg cgaaaagatt cagcttgata cgacttattt 1572661 cttaaaaggg acggagggtg catcttgatc aaaccaatcg aatatgaaca gcttcaggag 1572721 acgctgtatc atgaaaaaat gtccaacggc cttgatgttt acgttttgcc gaaaaaaggc 1572781 ttcaacaaga catatgcggt ctttacaaca aagtacggct cgatagataa ccggtttgtc 1572841 cctttaggta aaaacgagat ggttcacgtg ccggacggga ttgctcactt tcttgagcac 1572901 aagctgtttg agaaagcgga cggagacgtt tttcaagatt tcagcaaaca gggggcttct 1572961 gccaatgcgt ttacgtcatt tacaagaacg gcttaccttt tctcaagcac atcaaatgtt 1573021 gaacgcaatt tagagacgct tatcgatttc gtacaggacc catattttac tgaaaaaacg 1573081 gttgaaaagg aaaaagggat tatcgggcag gagattaata tgtacgacga taaccctgat 1573141 tggaggcttt acttcggggt cattgaaaac atgtacaaag agcatcctgt cagaattgac 1573201 atagcgggaa cagtggaaag catttcacat attacaaaag accttcttta tgaatgctat 1573261 gaaacgtttt atcacccgag taacatgctc cttttcattg tcggccctgt agatcctgaa 1573321 gcgattattt ctcaggtaag agaaaaccag gggaaaaagc cgtatactga tcagccggag 1573381 atcaaacgag aagaagtgaa agagcaagaa gcggttttcc gaaaagaaaa agagatcaaa 1573441 atgaacgtgc agggaccgaa atgccttgtt gggctgaaat ccaaaaatcc gtttaaatta 1573501 ggcaaagagc tcttaaagca tgaactttca atgaacttat tgcttgaagc tctttttggc 1573561 aaaagctctg cccagtatga atcactttat gaaaaaggat atattgacga aacgttcagc 1573621 tttgatttta ctgctgaata tgggttcggt tttgcggcga tcggcggaga tacgcctgag 1573681 cctgatcaat tggctgaaga catttcaagc atgcttttgc gcgccggtga actgattact 1573741 gctgaaaaga ttgaacttgc cagaaagaaa aagatcggca cattcttaaa agcgctgaat 1573801 tcccctgaat acatcgccaa tcaatttacc cgttatgcgt tcttggatat gagcctgttt 1573861 gatgttgtaa cggtactcga gcagattacc ctcgaggatg tccagaacgt aatacaagag 1573921 gaaatcgctg cagacagact gactgtctgc aaggttgttc ctaaatcata aacaaaacat 1573981 ccctccagtg tgaggggtgt ttttctgcgg aaagaaggaa agaggatgaa caaaacagca 1574041 ctaatcaccg gagcaagcgg cggcattggc aaaagcatca gcgaaaccct tgcagctaga 1574101 ggatacaatc tgctgctgca ttacaataca aatcaaaacg cggcagcgga gcttgctgaa 1574161 aaactaagtc agatgtttgg cgtaaatgcg gagatattac aagctgacct gtccgcgcaa 1574221 gatggagcag ataagctgac aagttcaatt gttcagccga ttgatgcgat tgttttaaac 1574281 agcggacgaa gccattttgg gctgattacg gatgtagata acgcaacggt ccaggaaatg 1574341 gttcagcttc atgtggcgag tccgtatatg ctgacgagaa accttctgcc aggcatgatt 1574401 cggaataaat cgggagcgat tgtggctgtc agctcgattt ggggagagac tggagcatcc 1574461 tgtgaagtgt tgtacagcat ggcaaaagga gctcagcatt catttgtaaa aggattggct 1574521 aaggagctgg cgccaagcgg aatcagagta aacgccgtag cgccgggtgc agttgataca 1574581 aatatgatga atcaatttac cccggctgaa aaagaagaga tcgctgatga gattccgatc 1574641 ggccggctgg cccggccgca agaaattgcg gatgcaacag cttttctcct gtctgaaaaa 1574701 gcgtcatata tcaccggcca aattctgtcg gtgaatggcg gctggcactg ctgatccgaa 1574761 aatattcggt gtatagtttc ttttgcgaag gacacaataa tcttgtaact tcacatgaaa 1574821 tggaggaaac aagcatgtca gtattagaaa actgggatag ctggaaaaac ttccttggcg 1574881 accgtctgaa ctatgcgcaa gataaaggta tgagccagga tacgattaca gatcttgcga 1574941 cagaaatcgg cagctacttg gctaatgaag tggaatctaa gaacgagcag gaaaaagtgc 1575001 tggcagatct ttggagtgta gcatcaaaag atgaacagca cgccattgcc aatatgatgg 1575061 ttaagcttgt tgaaaataac agcactcact aggaagagag gggatttttc ctctcttttt 1575121 tatgttttcc tcatcacagc aacattcttc tttctaatta gagaaaaatg ctttatgata 1575181 aaggaaggta aaattttgcc acaatgaagg gggtatatca tttggcaaag ctcgaatggt 1575241 attttgaata tgaaattcaa gtgaaccgcc ccggactgct cggggatatt tcatctcttc 1575301 ttgggatgct ttctatcaac atcgtaacga taaacggcgt cgatctttcc agaaggggaa 1575361 tgctcctcag gtgccgccat atagatcaaa ttaaacgatt agaatcaatc ttaaaaacga 1575421 tggaaacaat taaagtaacg aagcttagag aaccgaggct tcgcgaccgt cttgccgtac 1575481 gccacggccg ttatattcaa cgggatgccg atgacaagaa aacgttccgc tttgaacggg 1575541 acgagcttgg cttattagtc gattttatgg ccgaattgtt caaaaaagaa ggccataaat 1575601 taatcggaat cagaggtatg ccgcgtgtcg ggaaaacgga atcgattgta gcctctagtg 1575661 tgtgcgagca aaaggtggct gtttgtgtca tcaaccttgc tgaagcagac gataagaagc 1575721 cagctgattg ccgatgaata cagcactgaa aatgtcttta tcgttgacgg aattgtgtca 1575781 acacgaagag ggtcagaacg ccatctccag ctggtccgag aaatcatgcg gctgcctgca 1575841 acaaaagtgg tggagcatcc ggacatattc gttcaaaata cagagtatac actagatgac 1575901 tttgattata ttattgaact gagaaatgac cctgatgagg ttattacata tgaacatgcc 1575961 gaggaacccc aaatgtttga tcaatccggg ttttcaagct ttgattttta aaattggaag 1576021 gtgtttgttg tgactgaact aggaatccgg ctcaaagaag ccagagagga aaaagcaatg 1576081 tcattggatg atctccaagc ggcaacaaag attcaaaaaa ggtatttaac cgccttggag 1576141 gaaggaaact atgacattat tccggggaag ttttatgttc gggcattcat caagcaatat 1576201 gcagaagccg ttgggcttga tgcggatcag ctgtttgagg agcataaaaa agatatccct 1576261 aatacgtatc atgatgatgt gtctgaaaag atctccggca tgaatcttca aaaggaaatg 1576321 ccaaagccag catctaaggc gctggagctg ctgccaacaa tacttgttat tctcggcgtg 1576381 attgtcgtga ttgccattgt gtacgcgatc attcaatttg ccaatcacaa aaacagtgat 1576441 gatcacaatg cggcatcaga aaaagcaatt acgcaaagtg agagcaagta cgaaatccct 1576501 aaagattcaa cgctgaaaga gaatcaaaat aacagctctg aaaaagagac agacactaaa 1576561 aaagaaacga aagaaaacga agataagaaa aaagaaaatg acagtgagaa gctggagatt 1576621 aaagctgctg gcactgaagg atcgttaacg acttatgaag tgtccggcgc tgataaaatc 1576681 gagctggaac tgaaggcatc agacagctcc tggattagag tgcgcgatga aaacagcagc 1576741 tctttaaaag aaggaacgct gaaaaaagac gaaacctata aaaaagacat aactgatcag 1576801 aaacaagttg atatccgcac cggatatgca cctaatctga aaataaaaat caacggtaag 1576861 gttctttcat atgaacttga tccgaaaaaa gtgatggcac aaaccataaa gattgtaaat 1576921 aaaaaggaag aaaagtcatc ttaattacca gatgactttt cttcacgtcc gagtatgaaa 1576981 ttggaggggc tttatgttta acttaccaaa taaaatcaca ctagctagaa tcgcattaat 1577041 cccaatcttc atgattatca tgctggcgcc gtttgactgg ggcaggctcg aagttggaga 1577101 cgaatccatc ccggtcgcac atttggcggg ggccattcta tttattattg catctacaac 1577161 agactgggtg gacgggtatt atgcccgaaa attaaatctc gtaacaaact tcgggaaatt 1577221 tcttgatccg cttgcggaca aactgctcgt atccgcagcg ttaattatcc ttgttcaatt 1577281 tgatctcgct ccagcttgga tggtcattgt gattatcagc agggagtttg ccgtgacagg 1577341 tttaaggctt gtcttagccg gaacaggaga agtcgtagct gctaacatgc ttggtaaaat 1577401 caaaacctgg gcacagatta ttgcggtatc tgcattgctt cttcataatc ttccatttga 1577461 acttgtgtca ttcccgtttg cagacttggc gctgtgggta gccgtcttct ttactgtcgt 1577521 ctcaggctgg gaatatttct ctaaaaattg ggaagcgtta aaaacatcta actaagaaag 1577581 aaggacttcg tcatggaatt tccaaaaaaa gcagaaataa ttgcagtcgg ttcagagttg 1577641 ctgcttggtc aaatcgccaa tacaaatgct caatttatca gcaaacagct cgctgaaatc 1577701 ggggtcaacg tattttatca tacagcggtc ggagataacc cggagcggct gaagcaggtc 1577761 atccgcattg ctgaagaacg ctctgacttc attatttttt caggagggct tggacccaca 1577821 aaagatgatc tgacgaaaga aacgattgca aatacgctgg gacgtccgct tgtgttaaat 1577881 gatgaggcat tccaatccat tgaggactat ttcaaacgaa caaaacgcac gatgtcacct 1577941 aataaccgaa aacaggcgct tgtgatcgaa ggctctgacg tgctggcgaa tcactttgga 1578001 atggccccgg gaatgctcac agagcatgaa tcgcgctatt atatgcttct tcctggaccg 1578061 ccgagcgaat tgcgtccaat gtttgaaaac gaggcaaagc ctcttctgct gaaaaagatg 1578121 ggttcaaatg aaaaaattgt gtcaactgtt cttcgctttt tcggtatcgg tgaatctcag 1578181 cttgaagccg atttggaaga tattattgat gcacaaacca atccgacaat tgcgcctttg 1578241 gcggctgatg gagaggtgac gctgcgtctg acagccaaac acgccgatga aaaggaaaca 1578301 gagcgtctgt taaaagaaac agaggccgtt atcttagagc gtgtcggtga atttttctat 1578361 ggttacgatg atacttctct tgtaaaagag ctatctatag catgtaagga aaaaggcata 1578421 acaatttctg cggcagaaag ctttaccgga gggctgtttt ctgaatggct gacggatcat 1578481 agcggtgcct caaaattatt tgccgggggc gttgtttgct atacaaacga cgtgaagcag 1578541 aatgtgcttg gtgtcaagaa ggaaacatta gatcgttttg gggcggtcag caaggagtgc 1578601 gcatccgaac tggctaaggg tgttcaaaaa ctcactggca gcgatatcgg cattagcttt 1578661 actggtgtag caggacctga tgctcaagaa gggcatgagc ctgggcatgt gtttatcggc 1578721 atttccgcaa atggtaaaga agaggttcac gagtttcact ttgcgggctc cagaacgggg 1578781 atcagaaaac gcggcgctaa atacggctgc catttaatct taaagctttt agagcaaaaa 1578841 taatattttc agcacattat cctcctaaga aaacatgatt tctctgatac attatgatat 1578901 tttgatagga atcacgccaa gaaaaaatcc gaatatgcgt tcgctttttt cttggcaaat 1578961 cccttcaaac agggtatagt atatgtagtg gtaacataaa ggaggaaaaa atagaatgag 1579021 tgatcgtcag gcagccttag atatggctct taaacaaata gaaaaacagt tcggcaaagg 1579081 ttccattatg aaactgggag aaaagacaga tacaagaatt tctactgtac caagcggctc 1579141 cctcgctctt gatacagcac tgggaattgg cggatatcct cgcggacgga ttattgaagt 1579201 atacggtcct gaaagctcag gtaaaacaac tgtggcgctt catgcgattg ctgaagttca 1579261 gcagcagggc ggacaagccg cgtttatcga tgcggagcat gcgttagatc cggtatacgc 1579321 gcaaaagctc ggtgttaaca tcgaagagct tttactgtct cagcctgaca caggcgagca 1579381 ggcgcttgaa attgcggaag cattggttcg aagcggggca gttgacattg tcgttgtcga 1579441 ctctgtagcc gctctcgttc cgaaagcgga aattgaaggc gacatgggag attcgcatgt 1579501 cggtttacaa gcacgcttaa tgtctcaagc gcttcgtaag ctttcagggg ccattaacaa 1579561 atcgaagaca atcgcgattt tcattaacca aattcgtgaa aaagtcggtg ttatgttcgg 1579621 gaacccggaa acaacacctg gcggccgtgc gttgaaattc tattcttccg tgcgtcttga 1579681 agtgcgccgt gctgaacagc tgaaacaagg caacgacgta atggggaaca aaacgaaaat 1579741 caaagtcgtg aaaaacaagg tggctccgcc gttccgtaca gccgaggttg acattatgta 1579801 cggagaaggc atttcaaaag aaggcgaaat cattgatcta ggaactgaac ttgatatcgt 1579861 gcaaaaaagc ggttcatggt actcttatga agaagagcgt cttggccaag gccgtgaaaa 1579921 tgcaaaacaa ttcctgaaag aaaataaaga tatcatgctg atgatccagg agcaaattcg 1579981 cgaacattac ggcttggata ataacggagt agtgcagcag caagctgaag agacacaaga 1580041 agaactcgaa tttgaagaat aaaaataaaa taagtttcaa atgatacaaa aggctgagtg 1580101 aaaaactcag cttttttgta ttttgcaaaa aaatgataaa aatattgctt tttttgacaa 1580161 cttttttagg gctttattcg tctaacaaaa cgtgtgcaaa atggaattta ttttgggagg 1580221 aaaaaatgaa tgacaagccc aacccgcaga agaactgcga aacgcagacg gagaaaacta 1580281 aataaaagag gaaaactgtt gtttggtctt ttagcagtga tggtttgcat tacgatttgg 1580341 aatgctcttc atcgaaatag tgaagaaaac gaaccatctc aagaaactgc agcggtttca 1580401 aataccgatc agaaaaaaga ggtcaaaaag aaaactgcca aaaaatcaga ggaacaaatc 1580461 aaaacagtgg atcgaaacca aaaaatcagc aattatttaa aagagatcgg tttcagcgga 1580521 acagccatga ttgtcagaaa tggagaaatc gtaacaaata aaggttttgg ctatgctgac 1580581 cgtaaacact acattcaaaa taatccattg acatcttttt atgtcggttc atcacaaaaa 1580641 gcgctgattg caactgctat tttgcagctt gaggaaaagg ggaaacttca gacaagtgat 1580701 ccggtaagca cgtatttacc tcattttccc aacggacaaa cgattacttt gaagaatctg 1580761 cttacacata catcggggat aaacggacat attgaaggaa acggcgccat tactccggac 1580821 gatttaataa aagatataga acttcaggga atcaaacgtc agccgggcgt atgggactac 1580881 aaggattcca actattctgt tcttgcttat attattgctg aagtaagcgg tgagccctat 1580941 gaacagtaca taaagaatca tatttttaaa cctgcgggaa tgacgcatgc aggcttttac 1581001 aaaacatatg aaaaagaacc ttatcctgcc gtcgggtata agatggaggg cagcaaaaca 1581061 gttacaccgt atatacctga tttatcccag ctgtatggag cgggtgatat ttatatgagc 1581121 gctatagata tgtacaaatt tgaccaagcg ctgatagacg gaaaactgta ttcgcaaaaa 1581181 agctatgaaa agatgtttac gccagggagc agctccacat acggcatggg attttatgtt 1581241 gctcccggaa gctattcaaa ccatggtgtt atgccgggct tcaatatctt gaacagcttt 1581301 agcaaatctg ggcaaaccat tgttattttg ttctcaaaca ttcaaaataa tgctaaattg 1581361 ggccaagtga acaataaaat ataccagctt ctaaatcaag aatgattggc gatcttcttt 1581421 tggatgaatt gcattcggca cgtgaaaaga agactggcct gcaaacgtta agatggcaag 1581481 cttgacaagt atttccgaca catttacaat gaagttgtaa catttgtttt tttaacatga 1581541 ttgttaaacc atttaaactt gacaagggcg atgaacacac tcattccctg tgaaggttct 1581601 gtatgttgag aaaactagac aatgtacatg ccgacacttt ttaagcaaca accaagttca 1581661 tagcaagagg aggtgaaagt atgaccccaa ttatgatggt tctcatctcc attttgctga 1581721 ttctactcgg tttagttgtt ggctactttg ttcgtaaaac cattgccgaa gcgaaaattg 1581781 cgggcgcacg cggtgcagcc gagcaaattc ttgaagatgc gaagcgtgat gctgaagcac 1581841 tgaaaaaaga agctctgctt gaagcaaagg atgaaatcca caaacttcga atagatgctg 1581901 aacaggaagt tcgtgaaaga cgaaatgagc ttcaaaaaca agaaaaccgt ttactccaaa 1581961 aggaggaaaa ccttgatcgc aaacatgagg gaattgataa acgggaagcg atgttggaga 1582021 agaaagatca ttctctgaat gaacgacaac aacatattga agagatggaa agcaaagtgg 1582081 atgagatgat tcgtatgcag cagtctgagt tggaacgaat ttcgagtctg actcgtgacg 1582141 aagcgaaaca aatcattctt gagcgggttg aaaacgagct ttcacatgac atcgccatca 1582201 tgacaaaaga aactgaaaac cgtgcgaaag aagaggcgga taagaaagcg aaaaacattc 1582261 tttcactcgc cttacagcgc tgcgcagcgg accacgttgc cgaaacaacg gtatcagttg 1582321 tcaatcttcc aaatgatgag atgaaaggac gtatcatcgg acgggaaggg cgtaacattc 1582381 gtacgcttga aacgctgaca ggaattgacc tgattattga tgatacgcct gaagctgtca 1582441 ttctttccgg atttgatccg atcagacgtg agacagccag aattgctctt gataaactcg 1582501 ttcaggatgg ccgtattcat ccggcacgga ttgaagaaat ggttgaaaaa tctcgccgcg 1582561 aggtcgatga ctatattcgt gagatgggtg agcaaacgac atttgaggtt ggcgttcatg 1582621 gcctccaccc agatctcatc aagatcctcg gccgcttaaa gttccgtaca agctacggtc 1582681 aaaatgtgct taagcattcc atggaagtcg cattcttggc cggtctaatg gcatcggagc 1582741 ttggtgaaga cgcaaagctt gctaaacgtg cgggtcttct tcacgacatc gggaaagcaa 1582801 ttgaccatga agtagaagga agccacgttg agatcggggt agagcttgcg accaaatata 1582861 aagagcaccc agtcgtgatt aacagtattg catcacacca cggggacgag gagccgactt 1582921 ccattattgc tgtactggta gctgcagcag atgcgctttc cgctgcaaga cctggcgcaa 1582981 gaagtgagac gctcgagaat tatattcgaa gacttgaaaa acttgaagaa atttctgagt 1583041 cctacgaagg tgttgaaaaa tcatttgcca ttcaggctgg acgcgaagtg cgaattatgg 1583101 tgaagccgga ttcaattaat gatcttgagg ctcatcgact ggcgcgagat atccgcaagc 1583161 gaattgagga cgagctcgat tatccaggtc atattaaggt gacagtaatc agagagactc 1583221 gagccgtaga gtatgcaaaa taaagtgatg cgctaagcat cactttattt ttttgacggc 1583281 aaggaatttt caagaagaaa ggatttacaa aatgagaatt ttatttatcg gagatgttgt 1583341 cggttcaccg ggccgtgaca tggtcaaaga atatgtacca aagctaaaaa caaaatataa 1583401 gcctcacttt accattatta atggtgaaaa cgccgcacat ggaaaaggcc tgacggaaaa 1583461 aatttatcac agcttaatcc agtccggcgc agatgcaatc acaatgggga accacacatg 1583521 ggacaaaaaa gaaatatttg attttataga tgacgttccg aacttggttc gcccggcaaa 1583581 ctttcctgaa ggaacaccgg ggaaagggat cacatatgtg aaagcaaacg gcaaagaact 1583641 agcagtcatt aatttgcagg gacgtacgtt tttgccgccg cttgatgacc cgtttttaaa 1583701 agcggatgaa ttgatcgcag aagctgcgaa aagaacaccg tacattttta ttgactttca 1583761 tgccgaagcg acaagtgaaa agctcgcact tggctggtac acggatggac gggcatcggc 1583821 tgtagtagga actcatacac acgtgcaaac agcggataac cgcattttgc cgaagggaac 1583881 ggcatatatt actgatgtgg gaatgactgg cccgtatgac ggtatactgg ggatggacag 1583941 agagacgatt attaagcgat tcaaaacgaa ccttccagtc cggtttactg tcgctgaagg 1584001 aaaaacaacg ctcagcggag ttgtcattga cattgacgat caaacgaaaa aagccgtgaa 1584061 aattgagcgt attttaatca acgatgatca catgttcttt gaatagttga acatatggtt 1584121 attttataaa aatattaaaa agaaaagcag gaatatagca actccttagt gaatatagta 1584181 aaaatggaag gtagcccgct atttttgaaa agcattgtgg ggatggcttt ttggatagca 1584241 acatctaata atgattgttc taatgaacac tcacttatcc attgtaaaac taagggggag 1584301 cagaaatgga aatcttaaaa gtttcagcaa aatcgagtcc aaattcagtg gcaggtgcgc 1584361 ttgcaggcgt gttgagagag cgaggagccg ccgagattca agcgatcgga gcgggtgcat 1584421 taaaccaggc tgtaaaagct gtggcgattg ccaggggatt tgtggcgcca agcggcgttg 1584481 atttgatttg tattccggct tttacagata ttcaaatcga tggggaagaa agaacagcga 1584541 ttaaattaat cgtggagcct cgctaaaaac aaataaagca ttctcaacct gtttgcgtaa 1584601 tgcaaacagg ttgtttttca tttattgtga tattttctcc cgatagtatt tttagcacat 1584661 aaatgagcga atatacaaaa tcagaaatga gctaaaacgt ttcaaaaaaa atttccgccc 1584721 atttttcaag acagatactt ttgtccttct ggaaaagaca gttctgttta cgcttattcc 1584781 atatcatggt acaatccgaa tataacaaga atttttcaag gaggattgta catgcagagt 1584841 ggaaagatga aagctctaat gaaaaaggac ggggcgttcg gtgctgtgct gactgaagtt 1584901 cccattcctg agattgataa acatgaagtc ctcataaaag tgaaagccgc ttccatatgc 1584961 ggcacggatg tccacattta taattgggat caatgggcac gtcagagaat caaaacaccc 1585021 tatgttttcg gccatgagtt cagcggcatc gtagagggcg tgggagagaa tgtcagcagt 1585081 gtaaaagtgg gagagtatgt gtctgcggaa acacacattg tctgtggtga atgtgtccct 1585141 tgcctaacag gaaaatctca tgtgtgtacc aatactgcta taatcggagt ggacacggca 1585201 ggctgttttg cggagtatgt aaaagttcca gctgataaca tttggagaaa tcccgctgat 1585261 atggacccgt cgattgcttc cattcaagag cctttaggaa atgcagttca taccgtactc 1585321 gagagccagc ctgcaggagg aacgactgca gtcattggat gcggaccgat tggtcttatg 1585381 gctgttgcgg ttgcaaaagc agcaggagct tctcaggtga tagcgattga taagaatgaa 1585441 tacaggctga ggcttgcaaa acaaatggga gcgacttgta ctgtttctat tgaaaaagaa 1585501 gacccgctca aaattgtaag cgctttaacg agtggagaag gagcagatct tgtttgtgag 1585561 atgtcgggcc atccctcagc gattgcccaa ggtcttgcga tggctgcgaa tggcggaaga 1585621 tttcatattc tcagcttgcc ggaacatccg gtgacaattg atttgacgaa taaagtggta 1585681 tttaaagggc ttaccatcca aggaatcaca ggaagaaaaa tgttttcaac atggcgccag 1585741 gtgtctcagt tgatcagttc aaacatgatc gatcttgcac ctgttattac ccatcagttt 1585801 ccattagagg agtttgaaaa aggtttcgaa ctgatgagaa gcgggcagtg cggaaaagta 1585861 attttaattc cataaagggg gataaacatg acgaaggaat ttgagttttt aaaagcagag 1585921 cttaatagta tgaaagaaaa ccatacatgg caagacataa aacagcttga atctatgcag 1585981 ggcccatctg tcacagtgaa tcaccaaaaa gtcattcagc tatcttctaa taattacctc 1586041 ggattcactt cacatcctag actcatcaac gccgcacagg aggccgttca gcagtatgga 1586101 gccggcaccg gatcagtgag aacgattgcg ggtacattta caatgcatca agagcttgag 1586161 aaaaagctgg cagcctttaa aaaaacggag gcggcacttg tattccaatc aggcttcaca 1586221 acaaaccaag gcgtactttc aagtattcta tcaaaagagg acattgtcat ctcagatgaa 1586281 ttgaaccatg cctctattat tgacggaatt cgactgacaa aggcggataa aaaggtgtat 1586341 cagcacgtca atatgagtga tttagagcgg gtgctgagaa agtcaatgaa ttatcggatg 1586401 cgtctgattg tgacagacgg cgtattttcc atggatggca acatagctcc tctgcctgat 1586461 attgtagagc tcgctgagaa atatgacgca tttgtgatgg tggatgacgc ccatgcatcc 1586521 ggagtacttg gcgaaaacgg caggggaacg gtgaatcact tcggtcttga cggcagagtg 1586581 catattcagg tcggaacatt aagcaaggca atcggagtgc tcggcggcta cgctgcaggt 1586641 tcaaaggtgc tgatcgatta tttgcgccat aaaggccgtc catttttatt cagcacatct 1586701 catccgccgg cagtcactgc agcttgtatg gaagcgattg atgtcttgct tgaagagccg 1586761 gagcatatgg agcgcttgtg ggagaatact gcctatttta aagcaatgct tgtgaaaatg 1586821 ggtctgactc tcacgaagag tgaaacgccg attcttccta ttttaatagg tgatgaaggt 1586881 gtggcaaagc aattttcaga tcagctcctt tctcgcggtg tttttgccca aagtatcgtt 1586941 ttcccgactg tagcaaaggg aaaagccaga attcgcacga ttataacagc agagcacacc 1587001 aaagatgaac tggatcaggc gcttgatgtc atcgaaaaga cggcaaagga gctccagcta 1587061 ttgtaacaag aggaagagtt tactcttcct cttttgattc cttattgatt attattctca 1587121 atgagtgtac aatgataggt tgccagttgt gcagagcttc aataaccttt atactgaagg 1587181 gtggaagttt ggtttgaaag gagaaaatat gacatgaatg aaaaacaaaa attagagagc 1587241 ggacaagttc atccatcgga caaaaaatcc gagaaggatt acagcaagta ctttgaagct 1587301 gtttacattc cgccttcttt aaaagacgcg aaaaaacgag gcaaggaagc cgttacttat 1587361 cataatgact ttaaaatttc tgaacaattt aaaggattgg gagacggaag aaagttctat 1587421 atccgtacgt acggctgcca aatgaatgaa cacgatacag aggttatggc agggatcttt 1587481 atggcgctcg gttacgaagc gacaaactct gttgacgatg ccaatgtcat tttgttaaat 1587541 acatgtgcaa tccgtgaaaa tgctgaaaac aaggtgtttg gtgagctcgg gcacttaaaa 1587601 gcactgaaaa aaaacaatcc cgatctgatt ttaggcgtgt gcggctgtat gtcccaagag 1587661 gaatcagtcg tgaaccgtat tttgaaaaaa catccgtttg tcgatatgat tttcggaacg 1587721 cataacattc atcgcctgcc ggagcttttg tcagaagcat acctttcaaa agaaatggtt 1587781 gtagaagttt ggtctaagga aggggacgtt attgaaaacc ttccaaaagt ccgaaatgga 1587841 aaaattaagg gctgggtcaa tatcatgtac ggctgtgaca aattctgtac gtattgcatt 1587901 gtgccttaca cacgcggaaa agaaagaagc cgccgccctg aggatatcat tcaggaagtg 1587961 agaaggctcg caagtgaagg ctataaggaa attactctgt taggccaaaa cgtaaacgcg 1588021 tatggaaaag actttgaaga tatgacgtac ggacttggtg atttgatgga tgaactgaga 1588081 aaaatcgata tcccgagaat ccgttttaca acgagtcatc cgcgcgactt tgacgaccgc 1588141 ctcattgaag tgctggcaaa aggcggaaat ctgcttgatc acattcatct tccggttcaa 1588201 tcaggaagct cagaagttct caagctgatg gcccgcaaat atgacagaga gcgttacatg 1588261 gagctggtgc gaaaaattaa agaagcaatg ccaaacgctt ctttgacaac ggacattatc 1588321 gtcggatttc caaatgaaac ggacgaacag tttgaagaaa cgctttctct ataccgtgaa 1588381 gtggagtttg acagcgccta tacgttcatt tactctccgc gtgaaggcac tccggctgct 1588441 aagatgaaag ataatgtacc gatgcgtgtg aaaaaagaac gcctgcagcg tctaaacgca 1588501 ctggtgaatg aaatttctgc taaaaaaatg aaggaatacg aaggcaaggt tgtcgaagta 1588561 ttagttgagg gtgaaagcaa aaataaccct gatattcttg ctggctatac tgaaaaaagc 1588621 aagcttgtca atttcaaagg gccgaaggaa gccatcggca aaatcgtccg cgtgaaaatc 1588681 cagcaagcga aaacatggtc gcttgacgga gaaatggtag gagaagcaat cgaggtgaaa 1588741 tgagatgacg ctctactcaa aaaaagacat tgtgcagcag gctcgaaacc ttgcaaaaat 1588801 gatttctgaa acagaagagg ttgatttttt caaacgggct gaagcgcaaa tcaatgagaa 1588861 tgacaaagtg tccacaatcg ttaatcagat taaagccctg caaaagcagg ctgtcaatct 1588921 gaagcattat gaaaagcatg aagcgctcaa acaagtagaa gcaaaaattg acgcgctgca 1588981 agaagagctt gaagagattc ctgttatcca ggaattcaga gactcgcaaa tggaagtaaa 1589041 tgacctactg cagctcgttg cacacaccat ttccaaccaa gtcacaaatg aaatcatcac 1589101 atcaaccgga ggcgacctgc tgaaagggga aaccggttca aaggtgaagc attcaaataa 1589161 cagctgttct ctctaaacac ggtgccttta caggcccgtg tttttttatc atttgtgcgg 1589221 ttaaaaatga actaaataat ctatgtacca aatgttcaat tggtttttct gtgctcagcc 1589281 gcgtataaac tttatcgcac ttataagtaa agtttctagg cacccctgca tacaatggaa 1589341 cagaaacttt gtatttttat attttattta taaaaatgca cactagacaa atgcccagca 1589401 taagataaca cgaagaagaa caaggaggca tgccggaatg tctgaataca gggaaattat 1589461 tacgaaggca gtagtagcga aaggccgaaa attcacccaa tgcaccaaca ccatctcgcc 1589521 tgagaaaaaa ccgagcagca ttttgggtgg ttggattatt aaccacaagt atgacgctga 1589581 aaaaattgga aaaacggtag aaattgaagg gtattatgat ataaacgtat ggtactctta 1589641 cgcggacaac acaaagacag aggttgtcac agaacgggta aaatatgtag atgtcattaa 1589701 actcagatac agagacaata attacttaga tgatgagcat gaagtgattg ccaaagtgct 1589761 tcagcagcca aactgccttg aagtgaccat ttcgccgaat ggaaataaaa tcgttgtgca 1589821 ggcagaaaga gaatttttgg cggaagtggt aggggaaaca aaggtagttg ttgaggtcaa 1589881 tcctgactgg gaagaggatg acgaggaaga ttgggaagat gagcttgatg aagagcttga 1589941 agacatcaac ccggagtttt tagtgggaga tcctgaagaa taaaaaaggg actaggggag 1590001 acagtacccc caagtctctt ttttatattg atatatcatt cttttatcac tttttgttta 1590061 tgttataatg aaggttggaa aatagaaacg ttgatacata gtgagggatt aaacaatggc 1590121 cggttatacg cctatgatac agcaatattt aaaaataaag gcagagcacc aggatgcctt 1590181 tttatttttt cgcctgggtg atttttatga aatgtttttt gaggacgcca aaaaagcgtc 1590241 acaagagctg gaaattacgt taacgagcag agacggcggt gcggctgaaa aaataccgat 1590301 gtgcggtgtg ccgtatcatt ctgcttccgc gtatatcgaa cagcttatta aaaaaggata 1590361 caaagtggcg atctgtgaac agacggaaga tccgaaagcc gcaaagggcg ttgtgaaaag 1590421 agaagtagtt cagctgatta cgcccggaac tgtaatggac ggcaaaggca tccatgagtc 1590481 ggaaaataat tttatcgcat ctgtttcagc ctgctcgaac ggatacggac ttgctctgtc 1590541 tgatttaaca acgggagaaa atttggctgt tttgattgaa cggcttgaag acgtcatatc 1590601 agaaatttat tcagtcggcg cacgggaaat cgtggtttca ggaagcttgg atgccgatac 1590661 agtggcacag ctgagagagc ggtgcggtgc aacgatttca attgaagacg gagaaacaga 1590721 cgaacacgta acgatcattg agcacttaaa taatgaagat ataacaaaaa catttctgcg 1590781 cttatatacg tatttgaaaa gaacccaaaa gcgcagcctt gatcatcttc agcccgtgca 1590841 ggtgtatgag cttgaggaag cgatgaaaat tgacttgtac tcaaagcgta atctggagct 1590901 gaccgaaacg attcgttcga aaaataaaaa aggctccctt ttgtggctgc tggatgaaac 1590961 aaaaacggca atgggaggcc ggctacttaa acagtggatt gaccggccgc ttatcagagt 1591021 caatcaaatc gaagagcgcc aagaaatggt ggaaacatta atgtcccatt tctttgaacg 1591081 ggaagatctg cgtgaacgtt taaaagaagt atatgactta gaacgccttg ccggccgcgt 1591141 tgcattcgga aatgtcaatg cccgggattt gattcagctg aaggaatcgt taaagcaagt 1591201 gcctggcatc aaacagctgg ttgcttcact ggctcatgac aaggccaagg aacgtgcaaa 1591261 gcgcattgac ccttgcgggg atgtacttga actgctggaa gaagcgctgt acgaaaaccc 1591321 tcctttatcg gtaaaagaag ggaacctgat taaagatggt tataatcaaa agcttgatga 1591381 atatcgtgat gcaagcagaa acggaaaaga ctggattgcc cgcctggaac agcaggagcg 1591441 ggaatacaca ggcattcgct ctttaaaggt cggctttaat aaagttttcg gttattacat 1591501 tgaagtgaca aaagcaaact tgcatttgct tgaggaaggg cgttatgagc ggaagcagac 1591561 gttaaccaat gcagagcgct acattacacc tgaattaaaa gaaaaagaag cgctcatttt 1591621 agaggcggaa aataacatct gtgagctgga gtacgagctg tttaccgagc tgcgcgagaa 1591681 agtgaagcag tatattccgc ggctgcagca gcttgcaaaa cagatgagcg agctggacgc 1591741 actgcaatgc tttgcgacaa tcagtgaaaa tcgccactac acgaaaccag agttctctaa 1591801 agatgaagtc gaagtgattg aaggcagaca cccggttgtt gaaaaagtca tggacagcca 1591861 ggaatatgtc ccgaacaact gtatgatggg cgataacaga caaatgcttc tcattacagg 1591921 tccaaacatg tcagggaaaa gcacgtatat gagacaaatc gcgctcattt ccattatggc 1591981 gcaaatcggc tgctttgtac ccgcgaaaaa agcggtgctc ccgattttcg atcaaatttt 1592041 tacgcgaatc ggcgctgcag atgatttgat ttccggacaa agtacattta tggtagaaat 1592101 gcttgaagcg aaaaatgcga ttgtcaatgc gacgaaaaac agcctcattc tgtttgatga 1592161 aatcgggcgg ggaacgtcca cttatgacgg catggcgctg gcacaggcga ttattgaata 1592221 tgttcacgat catatcggcg ccaagacgct gttcagcaca cactatcacg agctgaccgt 1592281 tcttgaggac aagctgcccc agctgaaaaa cgttcatgtt cgcgctgaag aatataacgg 1592341 aacggttgtc tttcttcatc aaattaaaga aggtgcggct gataaaagct atggtatcca 1592401 tgtagctcag cttgccgaac tgccgggaga tctgattgcg cgcgctcaag atattttaaa 1592461 agagcttgag cattcaggaa acaaaccgga agtgccggtg cagaaacctc aggtgaaaga 1592521 agagccggca cagctgtcct tttttgacga agcggaaaag ccggctgaaa caccaaagct 1592581 ttcaaaaaaa gaaaagcaag tgatcgatgc tttcaaatca cttaatatac tggatatgac 1592641 accgcttgaa gcgatgaatg aaatgtacaa gctgcaaaag aaattacatt aaaacggggt 1592701 gatgaatgtg gcaaaagtca tccaactgtc agatgagctt tcaaataaaa tagcggcggg 1592761 cgaggttgtg gaacggcccg cctcagtcgt caaagaattg gtggaaaatg cgatcgacgc 1592821 tgacagcaca gtcattgaaa tcgatattga ggaagcaggc cttgcatcca ttcgggtctt 1592881 ggataacggc gaaggaatgg agaatgaaga ttgcaagcga gctttccggc gccacgcaac 1592941 gagtaaaata aaagatgaaa atgatttatt cagggtgaga acgctcggtt tcaggggaga 1593001 agccctgccg agtatcgcgt cagtctctca tctggagatt acaacaagca ctggtgaagg 1593061 agctgggacg aagctcgtcc tccaaggagg aaacatcatt tccgaatcgc gttcctcaag 1593121 caggaaggga actgaaattg tcgtttccaa cctgtttttt aacacaccgg cccgtttgaa 1593181 atatatgaaa accgttcata cagagcttgg aaacattaca gatgtggtta accgtattgc 1593241 tctggcgcat ccagaggtat cgatccgcct gcgccatcat gggaaaaacc tgcttcaaac 1593301 gaacggaaac ggagatgtgc gccatgtact ggcagcgatt tacggcacgg ctgtcgccaa 1593361 aaaaatgctt ccgctgcatg tgagctcctt ggattttgaa gtaaagggat atatcgccct 1593421 cccagagatt acacgggcgt cgagaaacta tatgtcgtct gtggtcaatg gccgttacat 1593481 taaaaatttc ccgctcgtca aagcggttca tgaaggctat catacgcttc tgccgatcgg 1593541 acgccatccg attactttta tagaaattac gatggacccg attttagtcg atgtcaacgt 1593601 gcatccatcg aagcttgagg tccggctcag caaggaaaca gagcttcatg acttaatacg 1593661 tgacggaatt aaagatgtgt ttaaacagca gcagctgatt cctagtgccc aggtcccgaa 1593721 aaaatcagca cctgccatca aaaatgagca gcagtttata acctttgatg aaaagcctcc 1593781 ggaaaaaaaa gttccggaaa aatcgactgc gccatcttat tcaccgatga agctcagctc 1593841 agtcgtaaaa gagccggttg atgcggagga aaaattgccc cctctccaat ttgatgctcc 1593901 tcctatcgtt gatcaggaac aaacccttga ggtgtccgat gtttcagcag aacagcctga 1593961 aacatttgag caggaatgcc atgaggaaca gccgcagcca gcgtctgatc gggttccaat 1594021 tatgtacccg attggccaga tgcacgggac ttatatattg gcacaaaacg aaaacggcct 1594081 atatattatc gaccagcacg ccgcccaaga acgtattaaa tatgagtact tccgtgaaaa 1594141 ggtgggggag gttgagcctg aggtgcagga gatgattgta ccgctgacgt tccactactc 1594201 cacaaatgag gctttgatta ttgaacagca caaacaagag ctcgaaagcg tcggtgtctt 1594261 tttagagtca ttcggctcta acagttacat cgtccgctgc cacccagcct ggtttccaaa 1594321 gggagaagaa gcagagctta tagaagaaat cattcagcag gtgctcgact ccaaaaatat 1594381 agatattaaa aaacttcgcg aggaagcggc gattatgatg agctgcaaag gctccatcaa 1594441 agcaaatcgc cacctcagaa acgacgaaat caaagcgctt ctggacgacc tccgaagcac 1594501 atcagaccca tttacatgcc cgcacggccg cccgatcatc attcaccact cgacatatga 1594561 gatggaaaag atgttcaaac gcgtgatgta gcgggggtgg taggcattga tccattctct 1594621 gaatggatca atgctttttt tgtactcctt cgagtgtcag attataagaa acggttgtaa 1594681 acgtgtgagc agtgttaacg cattatactt catggttcct ccgtataaca aaatttccat 1594741 ttacaggcaa ttgggattaa tgtatatttt gggtgagggg gtggaaacat atggcatgtg 1594801 gtccgaagat cattatcttt ttggatgaac ttgatgatcc aaatgtgaga atcattttag 1594861 aatgcagaat ttaaattaca acattgtgtt ttgctccctg ttcgtgtgaa cagggagatt 1594921 ttttcgttta tataactggt gatgtccaaa tatagggtgt tatgaatttt ccatatctgc 1594981 catcggcttt aagctgcttc tctattaggc tggttatcaa aagcaagttc aatgatagcc 1595041 atgaaagctg atatcacaac aagcaagaca tctggaatat aaatagactg cataaagtaa 1595101 tctgcaaaac agatcgttat aagattgctg ataaaataca gtataaaagc aaaaagtgca 1595161 gtctttttca atgaaagtga ttttgccaaa atgatagaga taatctttgt gagtgggtct 1595221 atgattaaac ctacagcaaa gcaggctaaa ataaataaag ctaatgtttg attggaagcg 1595281 tatgtgatgc caagtatgga gaataagcct ttcatcccga agaaaaagcc gccgaagatg 1595341 actgcaagcg cgatggccgc gataaaagta atagatacaa ttccgattaa ttttgatctc 1595401 aggttaaaat ctttagagtg ctcgttctgt tctttttggt tcatgtatga cactcccttc 1595461 acctgcttac tcatacaaac agcacccttg aatcagccca aaatatctat aagtctgttt 1595521 tctgacgaaa atagtatagc atattttaac aaaaccaaaa aaggcccttt ccactgggga 1595581 agggcctttt tcatcatgtt aactcctgag attcgccgaa gctttctctt tttttggcca 1595641 aataaaatag ctggctgtaa tgagaaagtc aatgcctata atgacagtcc acagtttaag 1595701 aatgccgctc aacgcctcgg ttcgggaaga gtcattgata aaatagatca tccctgccaa 1595761 tagtcccgca ccaattaagt aggccagcac atgtcttagc cagcctttcg caccgtgctt 1595821 ggcatggtcc attccaaaac gtttcagcgg ttttgttcct ttttttgtca cataatattg 1595881 aaacttttca tctgcccatt gaatcatttg tttcccataa gcgatcgata taccgatgta 1595941 aacagctgca atcccatggg ctgcggtcgc tgaggctccg cggtaaaggt ccacaccagt 1596001 tgccgctaac aagatcaaat cgataactgg agttaaggca aggaatagca gtcctaatgt 1596061 atgtcgtttg aatacgtagc gtacagcaag ccccaaaaca atgacaaccc aaaacgcaat 1596121 ttcacagaaa acaatcatcc atgcgatacc gttcaatcca ttcccctctt ttcaatacag 1596181 ttgtattatt taaataatat gttaccatct ttgtttttgt aacacaactg tattataaaa 1596241 attgccccgc ctttgaacga aagctcaaag gcgctacgct gtattatttt gatgaaagtg 1596301 gctgtcagct gtgctggata tcaattgtat atactgcacg atctgttacg accttcaatc 1596361 cttcgttttc ttggtgaata tgaagctcac ctaataaagg aatctcatag gcattttgcg 1596421 gaagcggtac gtttccgtcc tcagtgaatg ttgttccttc gccttctaaa acaagctctt 1596481 ctttcgcaac ataatcatca ggatgattcg tactgcgtat agccactttt tgaaggtgga 1596541 gaacaatctg atccaagtct gatatctctt catcatgggt caattcacct tttctaatat 1596601 caagcgtctg gccgactttt gattccagcc attgagaaag ctgtgtattc gtgtgtgcca 1596661 tcaatattcc tccttttgat ctacacgata ctattcccaa ttgctgcatc ttttacacgg 1596721 gaaagagccg ccccactctt tatgtatgaa acagttcgct gttgagtgcc ttgatatagc 1596781 gtacggcaga acgctggacc gattcgtcgg cattttcttt gacaacttta gagaaagcat 1596841 tgtaaagccg gttgaattga agcggtttta ctttggctgc tatttcttca actttggagg 1596901 cgggaagggg aatgagattt gggtagctgt acataaagct gacccagttt cgatccgccg 1596961 caaccgtaat gatatctccg gtcaatagac agcctttccc ttcattgccc ttgctccaat 1597021 gcaaaacagc accgccttta aaatgtccgc ccagtcggta aaggtccagt cccggcttca 1597081 tattgagcgt ttcccctgac cagaagtgaa tgtgattgct tggccttgtc acccattctt 1597141 tatcatcctc atggatatag atcggcgcct gaaacgcttc agcccactca acctgagtag 1597201 agtaataatg tggatgagac aaggcgatgg cttgaatacc gcctaattcg ttgatttggt 1597261 caattgtctt ttggtcaaga tatgtcatgc aatcccacag cacattgaag cccttatgct 1597321 gaataagatg ggctgtttgt ccaatcgcaa actctggttc agttttgatg ctgtaaagat 1597381 gctcttcttc ctttttaagg atgttttgaa ggtttccttt ctcacgcatg tcttcaaggg 1597441 ttgtccaagt ttgtccatcg ggatgaatat actgtctttc atcctcgcaa atcagacacg 1597501 agttgggcgg atctacagtc tgtgcatgtt gcacaccgca tgtattgcag atataatatg 1597561 gcactttctt cacttccttc atctattttc cattatttta ccttatgatt atgaatattc 1597621 aaacgaaaaa accggcagtt ctgctgagag agaattgccg gcttttgatg atgtttattg 1597681 gccgggaacg gaattttctg cgttgacagc gcccgctccg tagatattcg gatcttcatc 1597741 tttccatttg tccgtgccgt ttttcaaaag ctcttttact tcatcagggg taagatccgg 1597801 gttttgctga agaattaaag ctgcgattcc tgcgcaaatc ggtgttgcca tcgaggttcc 1597861 tgacattgta aagtactgag accctacacg gcttgacttt tggagcttat caatataaga 1597921 attcggagag cgaagggaaa taatattaac acccggcgct aaaatatcgg gcttttcttt 1597981 cccgtatact gtcgggccgc ggcttgagaa ggaagcgaca gtatcatcat cgctgcttgc 1598041 agtattgtta tcgtcaagcg cacctactgt aatcaccttt tcgctcacgc ccgggcttgc 1598101 aatggtctgc gaatcagggc ctgagtttcc ggcagcgaca cagacgacaa tccctgcgct 1598161 ccacgcttcc tcaaccgctc tgactaacgg atcttcctgt tcatgatcat atctaagggc 1598221 atcgcccccg agcgacatgc tcataatatc aatcggttca tcggggttgt cctcattgta 1598281 ttgaatacac cactcaacac cctctataat atctgctaac gttcctgaac cctgcttgtt 1598341 taataccttt acgccgatga gattggcttc cggtgcaggt ccgcggtatt gaccggaaga 1598401 ggatgcaccg ctgcttgcga catcacctgc acagtgtgtg ccatgaccat tatcatcgta 1598461 cggctctgtt ttttgattga ccatgtccgc gaatccgata attcttcctt ctagatcagg 1598521 atgcgggtag attcctgtat cgacaacagc gacagtaaca ccttttcctg tcagggtttg 1598581 cccgtttctg acgacttcct tcgcatggct tgcttcggtt gccgtgtcta aaagcgcttt 1598641 gacttcgcgg tttaaataca ctttacggat attgctgcat tcagagagaa gggaatgtaa 1598701 tgctgaagga gtaacctcgg cgctgcagca gttgattttg ttgaagcggc tttttagctt 1598761 gctgcgtttt tctttttgca gcacctctcc agccatttga aagccggtct cgtgacagcc 1598821 ttcctcaaat tcgataatga ctgacatttt ttttctgttt tgcaatttgg tttcgaaaaa 1598881 tttatgcaag aagcaaggag tccatttgaa gggcttgtaa agttgcaata cggtttcccg 1598941 taacggccaa tctagcttgt gagcatttgc tctcaccatt tgtaccatag agtacccaaa 1599001 catgtatttt cctcctatta taaggttctc tgtatactct atgaacagat gataggtttg 1599061 gtaagtttgt ttgtcctctg taagagacag acaagagttt gtttttctga atctttcgca 1599121 ttagatacga tagattcaga agctgaggaa atcattgggg attgaaaaag aacgtttgtt 1599181 cgtattataa tgtgatcata tcaaactggg aaggggagag caaccgtatg aatttctact 1599241 tgcaccgatc tttggaaagc caaatgccaa tcagcattat atatgaagaa agacggaacg 1599301 attagtaaaa gaacgattat tgtgagacag aaaagcaaaa cgaaaatcaa agcattttgt 1599361 ttttcgaaac aacagatcag aacattttta ttggactcta tcctctcctg tgattttgtg 1599421 agaacaaata agcaaaatct ctattctgca ggccggtaac agctgtccgt ctcagcaacc 1599481 gggcagcctg ttactaaaac cctccttaaa cctatataca tttatttgcc aagtgaggtt 1599541 gttcctacct tttttgtctt tcctctcaac cttttttcac tcttatttga aatgaaccgc 1599601 taataaccgt gacaatcaat tgattttttg aaaccgggaa ctttttcact gatgatattg 1599661 tgtatacaat ggtaagataa aacctattgg ctaaacctca tataatgaac cgcgccattc 1599721 ttatgaaagg agttaaacat gagaagattt ttactaaatg tcatattagt cttagccatt 1599781 gtcttgttct tgagatatgt tcattactca ttggaaccag aaccatcaaa tcagccagat 1599841 acatattcaa atttcagcag cttggcagag aatgagagcc cagccgatta cgatatttca 1599901 tataatgaga aaaaaggaag caaagtctta attatgtctc cgcatggcgg aagaattgaa 1599961 ggcggagtaa gtgagcttgt gcgttatttc aataatgaat actctacata cctatttgaa 1600021 gggttgaagt cccatgataa ccaaacactg cacattacaa gcaccaactt tgatgagcca 1600081 ttggcaaaaa agaaaatcaa ggagcatcaa tatgtggtgg cttttcacgg atataaagga 1600141 gagaacaaga atacccttgt agggggaaca gaccgaaagc gggcgaaaat gattgtgaga 1600201 gcccttgagc ggagagggtt ttccgctgag ttagcgtcgt ctaaaagcgg tcttgctgga 1600261 ttgaatgccg aaaacattaa taaccaaggg gaaacggggc taagtatcca gctggaaatc 1600321 agccgtgagc agagagaagc attttttgat gatttttatt ataaaaatag aaaatacaca 1600381 aagaacagtg aattttatgc ttatgtcagt gcgatcaaag gtgtcctgga aaaagagtat 1600441 tcgtaacaag cagatcagaa gacaaaataa gagaagatca gtagactgaa ataggataaa 1600501 aaaggaggca aaacaatggc agatcatcat ttttatttaa aagcgaactg gccgggtaac 1600561 cgtaatgatg tcggtacgat cgaaagcgga aacctgatca catcgatttc cattcctaaa 1600621 gaaatggatg gcccgggaga agggaccaac ccagatgaaa tgcttctcgg ggcggcagcg 1600681 acctgttaca ttattacact tgcagcgatg atggagagaa gcgggctgga aaaagaagac 1600741 ttacagatgg agtcagaagg cattgtcaac gttacaaaag gagtctttac atacaaaaag 1600801 atcattcacc gtccctctgt cgtgcttaaa catgatgctt cacaagacga cgtcgcattg 1600861 gcgcacaaac tttgtaaaaa agcggagtcg tcatgcatga tttcgcgtgc aattcaagga 1600921 aatgtcgagc tgcagcttga agcctctgtg aaactgggtg gagaataaag aaaacagacg 1600981 gtcactcaca ggccgtctgt tttttatctt cagcgtgggc tttcgattga tttagcacga 1601041 ccacgcctgc aatgacaagc gtgagaccga atacaccttt taaactgatg gtttcgccaa 1601101 aaagcaaaaa cccgacaatt gctgtaagcg cggtaccaac gcccgaccat gttgcatacg 1601161 cgcttgataa gtcaattgtt tttaaagaaa agcttagaaa cgtaaaagca gaaagaaatc 1601221 cgactatgac tccggcaatg ggccaggctt gtgtaaatcc ttctgaaagc ttcaacatcg 1601281 tgctcccaaa cacttcagat acaatggcga gagccaaata aagcaatcct ctcatcttca 1601341 tcactccttt acggccaatt aagtaacacg acccctgata gtaataaaag aatcccgata 1601401 agccctttgg cattcagatc ttccttgaac cattttactc cgatcactgt cgtcagcacc 1601461 gtgcctgccc cgctccaagt cgcataggag aggctcaggg gaatatggtt taaagtcagg 1601521 gacagcatat aaaaggcgag ggaatagcca ataacgacca aagcacttgg cttccacttt 1601581 ttgaagccat cagatacttt cagcatggct gctcctatcg attccgaaca tatggcaatc 1601641 gtgaggaata tatatcctat caacatcatg aattctcctc actatatttt tagattagaa 1601701 aaaaaacttc agctagaaaa atattagtgt atgcctatgt atgagtcaag agattcattt 1601761 tcacacactt aaaaagaccc ctttttaagg ggtcttttgc gtttaataat aaaaagggaa 1601821 cggggcatac ggataatagg ggtatccgcc atacaaataa ggattaaata aagcgcttcc 1601881 tataagcccg cctgcaaggc cgccgataaa cggtcctcca aaaaatccga atggccggcc 1601941 aaacccataa ccaaatccgg gtcttccaaa cccgtaaccg aacccgaacg gtcttccaaa 1602001 cccaaatggt ctcccgaatc cgaacggcct tccaaatatt cttgtatctt cagggctgaa 1602061 atgctctaac tcgttcatgt tttctttcct cctgtaataa agtgtagatg atgcagtgta 1602121 ttcaccctgc ccggatttga ttgggcgaat cgaggaaaag gaggatgtga acacattggg 1602181 cctgtatcag tctgactggt caaaagcacc gccccacgca catgcttatc atgtcaaaac 1602241 aacgagagaa cagggccatt atcatctcat cgaagggttt actcagccgg caaacggatc 1602301 aaataccgat cagcatacac attactatac agggatcact tcatttgaaa acggccattt 1602361 tcatcggtat tacggaatct caggaccggc gattccctta gcagatggca cacattatca 1602421 tgaaatcgaa gaaacgacgt atctggccta taacgagccg attgagatcc agtacggagg 1602481 ggttgtgtac gatcccggag atgacagaag aaaaacgcat cgtcataccc tgaaaggaaa 1602541 gacaagggaa attgtcggca atgagccgct cggctggtag aaggatgttt accgatgcaa 1602601 aaaaagggca aaatggatag gtggttgtcc atgttgaatg ctataatggg gggagattta 1602661 taaaagagag tgatacatat tgaataatac gaagcagccc gttgtcattt tagtcggacc 1602721 gacggcagtg gggaaaacca atttaagtat tcagctagcc aaatccttaa acgcggaaat 1602781 tatcagcgga gattcgatgc agatttataa agggatggat attggaacag ctaaaattac 1602841 cgaacaggag atggagggag tgccccatca tctgattgac attttagatc cccaagactc 1602901 tttctctact gccgattatc aaagcttagt aagaaataaa atcagcgaga ttgcaaatag 1602961 aggaaagctt ccgatgattg tcggcggtac agggctttat atacaatctg tgctttacga 1603021 ttatacattt acggaagagg caaatgatcc cgtgtttcga gagagcatgc aaatggctgc 1603081 tgagcgggaa ggcgctgact ttcttcatgc caaacttgct gcagcagatc ccgaggcagc 1603141 agctgcgatt catccgaata atacaagaag agtcattcgc gcactggaaa ttttacatac 1603201 gtccggaaaa acgatgtccc agcatttgaa ggaacaaaaa cgagaacttc tgtacaatgc 1603261 agtgttaatt ggcctgacaa tggatagaga cacgctttac gaaagaatta atcagcgggt 1603321 cgatttgatg atgcagtcag gccttcttcc ggaagtgaaa cgcttatacg acaagaacgt 1603381 gagagactgt caatcaatac aggcgatagg ctataaagag ctgtatgcat attttgacgg 1603441 ttttgtgaca ctttccgatg ctgtcgaaca gctaaagcag aactcgaggc ggtatgcgaa 1603501 acgccagctg acgtggtttc gcaacaaaat gcaggtcaca tggttcgata tgacaccgcc 1603561 tgttgatatg gagctgaaaa aaaaggaaat tttcacacat atagcaggaa aactcgaact 1603621 ttaatcgaaa ctgtatgata tagagaatca aggaggacga aacatgaaac cgattaatat 1603681 tcaggatcag tttttgaatc aaatccggaa agaaaatacg tatgtcactg tttttttgct 1603741 gaacggcttt cagttgcggg gccaggtgaa aggctttgat aactttaccg tattgttgga 1603801 atcggaaggt aagcagcagc ttatatataa acatgcgatc tcaacgtttg cgccgcaaaa 1603861 aaacgtccag cttgaactcg aatagatcaa aaaatgccat gtcaagacat gaggaaaggc 1603921 tgtcgggggt tcccggcggc catttttaac atgaatccac ttttgctcca agctttttgt 1603981 gtaagctgac catgccaagg cacggtcttt ttttatgaga acaacatacg gaagtaaaaa 1604041 tggtatatta tgtataaaat gaatttggga gtgatcgatc ttgtttgaaa gtgaagcaga 1604101 actgagacga atcaggattg cacttgtatg gatagctgtc tttttactgt tcggggcgtg 1604161 cgggaatcaa gataccatta ttgaaacaga caacggcaat tcagactatg aaacgcctca 1604221 gcccacctcg tttccacttg aacataacca ttttggcgtt atggaggacg gctatatcaa 1604281 aatttatgag tataatgagt cccgcaatga ggtaaagctg aagaaagaat acgcggatga 1604341 tgagcttgaa taaaattcac aagcattcga atttacaaag cggatgccag ccgctaaact 1604401 aaatacagac acagatcaaa cagagggtga aaacatgaag cataaagtga tcgtgaatca 1604461 ttgggaagaa atttgcgaag atgattcttg ctatgaatac ggaacaagta tcattgtgaa 1604521 cggaaaagaa ttaatcagag aagcgtcaat tatcactgct ttgaaggcgg ttttagaaga 1604581 gatcggcgcg gatgttgaaa tagaagaaac agtagagagc gaaaaatgct gtgatagctt 1604641 aagaaaaaaa aatctagact actaagcagt tttttttcat gttatgatat acatcggcta 1604701 aaaacgacac cccgagtagg acgagagatg attctcgttc tgctctcttt tttgggccct 1604761 aatgagtctg cccgtttgcc tgatttgatc aaaatatgaa tttttcataa aaacgaatct 1604821 atatattgtg tttttgctag agggtagtat actatatata gtgttagtga tgagagattc 1604881 atattttttg ataggtcgtg ataaaacgtg gtacaaatca tatttgattc gaaaacaggg 1604941 aatgttcagc ggtttgtgaa taaaacaggc tttcagcaga tacgcaaggt ggacgaaatg 1605001 gaccacgtgg acactccgtt tgttttggtc acctacacga caaacttcgg ccaggtaccg 1605061 gcatcaacac aatcatttct cgaaaaatac gcccatctct tattgggagt cgctgcgagc 1605121 ggcaacaaag tatggggcga taactttgca aaaagcgccg ataccatttc aagacaatat 1605181 caggtgccga tcttgcacaa atttgaactc agcggcacat ctaaagacgt tgaattgttt 1605241 actcaggagg tagaaagagt tgtcacaaaa tcaagtgcca aaatggatcc agttaaataa 1605301 cgaaatcatg atccaaaaag atgggaaatt ccagtttgat aaggataaag aagctgtaca 1605361 tagctatttt gtagattata tcaatcaaaa cacagtcttc tttcacaatt taaaagagaa 1605421 gctggattat ttggttgaaa accaatacta cgaagaggaa ttcttaagcc tttattcttt 1605481 tgaagacatt aaagaagtgt ttaagacagc ttacgctaag aagtttcgtt ttccttcctt 1605541 catgagtgcg tttaaattct ataatgacta tgctttgaaa acgaatgaca agaaaaaaat 1605601 cctcgagcgt tatgaggacc ggatctcaat tgttgcgctg ttcttcgcta acggcgacac 1605661 tgagaaagca aaagaatatg taaacctgat gatcaatcaa gaatatcagc cgagcacacc 1605721 gacatttttg aatgccggca gaaaacgccg cggtgaactt gtgagctgct tcttgctcga 1605781 agttaatgat tctttaaatg acatttcaag agcaatcgat atctccatgc agctttctaa 1605841 gcttggtggc ggggtttctc ttaacctgtc caagcttcgc gcgaaaggtg aagccattaa 1605901 agatgttgag aatgcgacaa aaggcgttgt aggcgtcatg aagcttcttg ataacgcgtt 1605961 ccgttacgct gaccaaatgg gacaaagaca aggctccggc gcggcgtatt taaacatttt 1606021 ccaccgcgat atcaatgatt ttcttgatac gaaaaagatt tctgcggatg aagatgtgcg 1606081 tgtcaaaacg ctttcgatcg gtgttgtcat tccggataag ttcgttgagc ttgcacgcga 1606141 ggacaaagcg gcttatgtat tctacccgca cacgatttat aaagagtacg gccagcacat 1606201 ggatgagatg gacatgaacg aaatgtacga caagtttgtc gacaaccctc gggtgaaaaa 1606261 ggaaaaaatc aacccgcgga aactgcttga aaaattggcg atgcttcgtt ctgaatcagg 1606321 ctatccatac atcatgttcc aagataacgt caataaagtg catgcgaata accatatttc 1606381 caaggtcaaa ttttctaacc tttgctctga agtgctgcag gcatctcaag tttcttcata 1606441 cacagactat gatgaagaag atgaaatcgg tctggatatt tcctgcaacc tgggttcgct 1606501 taacattctc aatgtcatgg agcataaatc aatcgaaaag acagtcaagc ttgcgacaga 1606561 ctctttaaca cacgtgtctg aaacaacaga catccgtaat gcgcctgctg taagacgggc 1606621 aaacaaagcg atgaaatcaa tcggcctcgg tgctatgaac cttcacggct accttgcgca 1606681 aaacggcatt gcgtatgaaa gtccggaagc gcgtgacttt gcaaacacgt tctttatgat 1606741 ggtgaatttc tactccatcc agcgttctgc ggaaatcgca aaagagaagg gcgaaacgtt 1606801 tgatcaatat gaaggatcaa cctatgcgac aggtgaatac ttcgacaaat acgtttcaac 1606861 tgatttctca ccgaaatacg aaaaaatcgc taatctgttt gaaggtatgc atatcccgac 1606921 gacagaggac tggaaaaagc taaaagcatt tgtcgctgaa cacggtatgt atcacagcta 1606981 cagattatgc attgcgccga caggctctat ctcatacgtt caatcaagca cggcgtctgt 1607041 tatgccgatt atggaacgga ttgaagaacg aacatacggc aactcaaaaa cgtactaccc 1607101 aatgcctggg cttgcatcta ataactggtt cttctataaa gaagcctacg atatggacat 1607161 gttcaaggtt gtggatatga tcgccactat ccagcagcac attgatcagg gaatcagctt 1607221 tacattgttc ttaaaagaca caatgacgac ccgagattta aaccgaatcg atctgtatgc 1607281 acatcataga ggaattaaaa ccatttacta tgcaagaacg aaagatactg ggcaagacag 1607341 ctgcctttct tgtgttgttt gattaaagga gagtttatag tgacaaaaat ttatgacgca 1607401 gcaaactggt caaagcatga agacgatttt acccaaatgt tctataacca aaacgtgaaa 1607461 cagttctggc ttccggaaga gattgcttta aacggcgatc tcctcacatg gaagtacctc 1607521 ggaaaaaatg agcaggacac ttatatgaag gtactggccg gacttacgct tcttgacaca 1607581 gagcagggga atacggggat gccgatcgtg gctgaacacg tagatggcca ccagcggaaa 1607641 gcggtgctga actttatggc gatgatggag aacgctgtcc atgcgaagtc gtactctaat 1607701 attttcatga cccttgcacc gactgaaacg atcaatgaag tatttgaatg ggttaaacaa 1607761 aataaatatt tgcagaaaaa agcgcaaatg attgtcgggc tttacaaagc cattcaaaaa 1607821 gatgatgaaa tttcactgtt caaagccatg gttgcttccg tctatctgga aagcttcctt 1607881 ttctacagcg gtttctatta tccgttatat ttctacggac aaggaaaact gatgcaaagc 1607941 ggtgagatca ttaacctgat ccttcgtgac gaagcgattc acggcgtgta tgtcggtctc 1608001 cttgctcagg aaatttataa taaacagaca gaagagaaaa aagcagagct tcgtgaattt 1608061 gcgatcgacc tcctgaatca gttatatgaa aatgagcttg agtatacaga ggacttgtac 1608121 gatcaagtcg ggctctcaca tgatgtaaag aaattcatcc gctataatgc gaataaagcg 1608181 ctgatgaacc ttggatttga tccatacttc gaagaggaag acattaatcc gatcgtttta 1608241 aacggattaa acacaaaaac aaaatcgcat gacttcttct ctatgaaggg gaatggctat 1608301 aaaaaagcga cagttgagcc gctcaaagat gatgactttt attttgaaga tgaaaaagag 1608361 cagatataat atctgctctt ttcggcttga aggttcaaat gaggaggacg cagtacccat 1608421 gggaaaaatg gacgaaatga ttttagttgc cccgcgcgat gatgtgttta aaaaagaaag 1608481 cttaaccttc cagggcgtgt acagtgaaga tagcagagta gcagaaatca tggctcagat 1608541 tgaagcggcc tatcgtgaaa tgagaagagg ggacgcagaa gaagatccgc gtttcaagca 1608601 gccgatacct tatgtcgtca ttaagcgtga agatgaagtt tttctttacg agcggctggc 1608661 tggcggcggt gaatcacgtc tgcacaacaa gctttctctc ggttttggcg gccatatgaa 1608721 cgccatcgaa ggggcagctt catttgctga agtcttaaag ctgaacacag accgtgagct 1608781 tgaggaagaa ctgcaaataa atgaagaaga taaacaggcg attgtcacac tgggattgat 1608841 caatgatgat gaaaacagtg ttggcaaagt gcatatcggt attctttctg cgcttcaatt 1608901 aaagcctggc gcacaagtgg aagtgaagga gaaagaacaa attgcgggta aatggatgaa 1608961 agtttctgaa ttaaaacagg atgatatcta caaccgtctg gaaacatggt cacagtttgt 1609021 tgttgatatt cttgaataaa aaaacccggt ttctcgcgat gaggagccgg gtttttttat 1609081 gagacgctcg tccccgtctc ggctatgatt ctaggatcac aatagcgtca aagccggcat 1609141 ttttcgctct ggcagcgagg gtgtctgcat tgtctttgga tgaaaatgcg ccaatctgca 1609201 ctttgtataa tccgtccttt aaaaggacaa tcgagtcaaa acctttggct tcggcattac 1609261 ttgcgagcga gtcggcattc gctttgactt taaatgcgcc gatttgaacc ttatataacc 1609321 ctgagctgga agtcttttta aggttaaagg cttgctccag cccgtttgca tgtcctctcg 1609381 ctaagctttg aataaaactg ctcgttttca gcttatttgc atcggaaacg gtatcaatga 1609441 agccgttctc ggtcaagagg gcaggcattg ccgactccct taggacgtgg aagttcgctg 1609501 tttttttgcc gcgatcggca aagtcgacag cttgtatcac ttcagagtga attgtcgatt 1609561 gataagtcgt cgtcggggct cctacatctg gataaatata gctttcaaaa cctgtgcctc 1609621 ccccggaatt aacgtgaatg gacaaaaaga aatctgctcc ccagttattt gcggcatttg 1609681 tccggtcgtt taagctgaca tattggtcgc ttgtccggct cagcagcaga gaaacgcctt 1609741 catattcatt agttaatatc gtacgtaagg ctaaagcgat ttgcagggtt aacgttttct 1609801 cctgaaggcc attacctgtt gcgcctggat cagacccgcc atggccagga tcaataaaaa 1609861 ttttaaccat ttttcatcac ctcattacag gatatgaaaa aacacggctt ctgcttgtac 1609921 gattatcatt caactgaaaa atgaggaaat aaccctttca catccagaaa ttatttctcg 1609981 ggaaagcgca caattcaaca tgaagcgaca acagatacgg tccgacatga aatctgtgca 1610041 tacgccatat gtttgtatgt actatgggtt cggttaacct gcactgattc ctgctggttt 1610101 taagctttgc gttcatatta aatcaagcat ttaaaacgta aattgatgag gaaagctcct 1610161 ttcattaaag acaccgcttt ataaatcgaa aaaaagaaaa acacttcagg tatcttaggg 1610221 cgggtaatac gtttcgtaca aaaatcagcc cgttgtatga aaaagaaata atgagaaaga 1610281 agctcactat aatactctga caaaatgatt aaaaacaaaa tctcatggtt tgtccacccc 1610341 atgtccgtga atacaataag aaataaagta tttctcggga aagcgcagga ttccttattg 1610401 ttcccgaaaa aagcaattgt ttcgacacat gataggcgtt tgtcacaatc ggcatccgct 1610461 tgaatatcat atagagagaa cagagaggtg aagatgttgg agcgcgctgt gacttataaa 1610521 aacaacggac agatcaacat tattctgaac gggcaaaagc aggtgctgac gaatgctgag 1610581 gcagaggcgg aatatcaggc tgcattgcaa aaaaacgaag caaagcacgg cattttgaag 1610641 gaaatcgaaa aagagatgag cgcattagtt gggatggagg aaatgaaacg caacatcaag 1610701 gaaatatacg cctggatttt tgtgaaccaa aaacgcgcgg agcaaggctt gaaggttgga 1610761 aagcaagcgc tgcacatgat gtttaaagga aatccgggaa cgggaaaaac gacggttgca 1610821 cggctcatcg gcaagctgtt ctttgaaatg aatgtcctgt caaaaggcca cttaatagaa 1610881 gcggagcggg ctgacctggt cggggagtat atcggacaca ccgcccaaaa gacgagagat 1610941 ttaatcaaaa agtcattagg tggcattttg tttatagacg aagcctactc gctggcaaga 1611001 ggcggcgaaa aggactttgg gaaagaagcg atcgacacac ttgtaaagca tatggaagac 1611061 aaacagcatg agtttatttt gatactcgcc ggatattcac gggaaatgga tcattttctc 1611121 tcgttaaatc ccggactcca atcaagattt cccatctcca ttgattttcc ggattactct 1611181 gtgacccagc tcatggagat tgcgaaacga atgatcgatg aaagggaata ccagctcagt 1611241 caagaagcgg aatggaaatt gaaagattac ttaatgacag tgaaaagcac gacaagtccc 1611301 attaaattca gcaatggacg ttttgtcaga aatgtgatcg aaaaatcgat cagagcacaa 1611361 gccatgaggc ttttaatggg agaccaatac ttaaaaagcg acttgatgac catcaaaagc 1611421 caagatcttt ccattaaaga agaagcatct ggatctgcat agacctctca gtttttgaga 1611481 ggtctgtttt ttgctcgtat ttccgctttt caaagcaatc gatttgtggt atacacatgc 1611541 agggtttggt atgataatac tactgcccaa tatgcaaaag aaaggaacat ccatttgaac 1611601 gaacaagaaa cgattcagga gaaagccatt ttagtcggat gtcagctgcc gcatatcacg 1611661 gatgagcatt ttgaaaattc tatggaagag ctagcatctc tgacgaaaac agcagacgga 1611721 aaagtactga ccagcgtcac acaaaaacgg aacagggctg acgccgctac atatatagga 1611781 aaagggaagg tagaagagct gaaggcactc gtggaagagc ttgaagctga tctcctcatc 1611841 tttaatgatg aactgtcgcc aagtcagctg aagtcattgg caacagcaat tgaagtgaag 1611901 atgattgacc gcacgcaatt gatattagat atttttgcaa agcgggcgag aacgagagaa 1611961 ggcaaacttc aaattgagct ggctcagctg caatatgcac tgccgcgtct gacgggacaa 1612021 gggatcaacc tttcccggca aggcggagga attggggcaa gaggtcccgg ggaaacgaaa 1612081 ctggaaaccg accgccgcca tatcagaaat cgcattcatg aaatcaacac acagctttcc 1612141 actgtcattc gccatagaag ccgataccgt gaaagaagaa agaaaaacgg tgtgcttcaa 1612201 attgcgcttg tcggctatac aaacgcaggg aaatcaacat ggttcaaccg cctgacgagt 1612261 gctgacagct atgaagaaga cctcctgttt gccacgctgg acccgatgac cagaaaaatg 1612321 gtcctgccaa gcggctacag tgttcttctt tcagatacag taggatttat tcaggatctt 1612381 ccgacgacat tgattgctgc attccgctca acgcttgagg aagtaaaaga agcggattta 1612441 attctgcatt taattgattc ttcaaatgag gattatgcgg gacatgaaaa aacagtgctt 1612501 cggctgcttg aggagcttga agcagatgat atcccgatgc tgacggctta caataaacgt 1612561 gatcaaaaac tgcctgattt tataccgacc gccggaaggg atcacattat ggtcagtgcg 1612621 aaatttgagg acgacgctgc agcctttaaa gaagcgattc agcgctattt gcgccaagaa 1612681 ctgttaacgt cttttgaagc acatgtgccg gcaagtgaag ggaagctcct ttccagaatc 1612741 aaatcggaaa cgatggtaga ccgcttctat tttaatgaag aaaatgaaca gtatgacata 1612801 tccggctatg tccaagaaga gcaaagtatc atcggtgaat taaagaagta tatgtaggaa 1612861 ggaaatataa agacatgttt gacacattaa cacacggaga attattgaag aaaacggcaa 1612921 tggaagtgga agcggacatt gccggcattc ataaacaaat agaagaaatc agcgagcgaa 1612981 atgagtggag agtgcttcaa agctatagaa aacacaaagt aagcgacact catttcacgc 1613041 cgtctactgg atacggctat gatgatatcg gaagagacac gcttgaaagc atatatgcgg 1613101 atgtgtttgg cggagaagcg gggcttgtaa ggccgcaaat catttcaggc acacatgcca 1613161 tctcaattgc tttgttcggt gtcctcagac cgggggacga gctcctttat atcacgggca 1613221 agccgtatga tacgctagag gaaattgtgg gcgtcagggg tggagaaaac gctggttcgt 1613281 taaaggattt tcaaatcggc tataatgcgg ttgatctgac gaaagacgga aagatagact 1613341 atgatgcagt cgccgctgcg atcaatccga agacaaaagt aatcggcatt cagcgctcaa 1613401 aaggatatgc gaatcgccct tctttcttaa ttagtgaaat aaaagaaatg atccgttttg 1613461 taaaagaaat caatgaaaat ctgatcgtct ttgtggacaa ctgttacgga gaatttgtgg 1613521 aagagcttga gccttgccat gtcggagccg acctgatggc gggatctctc attaaaaatc 1613581 ccggcggcgg ccttgcgaaa acaggcggct acctcgtcgg aaaagcgaaa tggattgaag 1613641 cttgctcata ccgtatgacg tcacccggca tcggcagaga agcgggggca tctctttact 1613701 cgctccaaga aatgtaccaa ggcttctttt tggcgcctca cgttgtgtct caaagtttaa 1613761 agggagcggt gtttacagcg agattccttg aaaaactcgg cttcacttca aacccgaaat 1613821 gggatgcgaa aagaacggat ttaatacaat ccgttgagtt ttctgacaga gaaaagatga 1613881 ttgctttttg ccaggctatt caatttgcat cgccaatcaa tgctcatgtg acgccttatc 1613941 cagcctacat gcctggatac gaggatgatg tcattatggc agcagggacg tttattcaag 1614001 gagcaagcat cgaattatca gctgatggcc ctatccgccc gccgtatgta gcgtatgttc 1614061 agggaggatt aacctattcg catgtgaaga atgccatatg cagtgcagtg gattcattga 1614121 tgcaaaagca attaatttaa attttttaaa aatttctctg gatttgatgt taagaatcct 1614181 tacatcgtat tgacacataa tataacatca cctataatga aactaagtta agaaaaggag 1614241 gaaattgaga tgagtgataa tattcgccgc tcaatgcctt tatttccaat aggaattgtc 1614301 atgcagttaa ctgagttatc agcaagacaa attcgatatt atgaggaaaa tggactgata 1614361 tttccagcca gaagtgaagg aaatagacga ttattttcat ttcatgatgt agataaactg 1614421 ttagaaatca agcacctgat agaacaaggt gtaaacatgg caggaattaa acagattctg 1614481 gcgaaagccg aagccgagcc agaacaaaaa caaaacgaga agacgaaaaa accaatgaaa 1614541 catgatctgt ccgatgacga actgagacag ctcctgaaaa acgagctcat gcaagccggc 1614601 cgttttcaaa gagggaatac attccgtcaa ggcgacatgt cccgcttctt tcattaatcc 1614661 gttagcaact gttttgctat atacatttac cttttaagag gaggaatttt accaaatggc 1614721 aaagtacact agagaagata tcgaaaaatt agtaaaagaa gaaaacgtga agtatatccg 1614781 ccttcaattt actgacattc ttggaacaat caagaatgtt gagattcctg taagccagct 1614841 tggaaaagcg cttgataata aagtcatgtt tgacggttct tctattgagg gattcgttcg 1614901 tatcgaagag tcagacatgt acctgtatcc agatctaaat acatttgtta tcttcccatg 1614961 gacagctgaa aaaggtaaag tagcacgttt catctgtgat atttacaatc cggatggcac 1615021 accttttgaa ggtgacccgc gaaacaactt aaaacggatt ctgaaagaaa tggaagacct 1615081 cggcttcagt gattttaacc ttgggcctga gcctgaattc ttcttattca aattggacga 1615141 aaaaggcgag ccgacgcttg aactaaacga caaaggcgga tatttcgact tagctccaac 1615201 tgatttagga gaaaactgcc gccgcgatat cgtacttgag cttgaagaga tgggctttga 1615261 aatcgaagcg tctcaccacg aagtagcacc tggtcagcac gaaatcgact ttaaatatgc 1615321 tggagcagtc cgctcttgtg atgacatcca aacatttaaa ctagttgtca aaacaattgc 1615381 ccgtaaacac ggcctgcatg cgacatttat gccaaaacca ttgttcggtg taaacggttc 1615441 aggtatgcac tgcaatctat cactcttcaa aaatggtgtt aacgcattct ttgacgaaaa 1615501 cgcagatctt cagttaagtg aaacagcgaa gcacttcatt gcaggtatcg tgaagcacgc 1615561 aacaagcttt acagcagtaa caaacccgac agtaaactct tacaaacgtc ttgttcctgg 1615621 ctatgaagca ccttgttatg tagcatggag cgcgcaaaac agaagcccgc ttatccgtat 1615681 cccggcttct cgcggcatca gcacacgtgt tgaagtacgc agtgtagacc cagctgcaaa 1615741 cccatacctt gcacttagcg tattgcttgc tgcaggatta gacggaatca aaaacaaact 1615801 ggaagcgccg gctccaatcg accgcaacat ctatgtgatg agcaaagaag agcgcatgga 1615861 aaacggaatc gttgaccttc cagcaacact tgcggaagca ctagaagaat tcaaatcaaa 1615921 cgaagtcatg gtcaaagcgc tgggcgagca cctattcgaa cacttcatcg aagcaaaaga 1615981 aatcgaatgg gatatgttcc gcacgcaagt acatccttgg gaacgcgaac agtatatgtc 1616041 tcagtattaa tatctcaatc ccttggcact aaaagtgtca ggggattttt tatgttaata 1616101 ggtaataaat tatggagcgg catagtgttt aacacagcca ttaatcctca gacagtcaaa 1616161 tagccatttc tactccggtt gaaagcttct ctatttttgc ttcttattta tctttcctgt 1616221 attgatatat gtatgtaggg ttggacttat aacataaact attctggcca ttccgttctt 1616281 tcaattcatg accgggcttg ccatcagcat aaatctaggc taacagtctc catacatcct 1616341 gtgatcacct ttatcaaact cttaaatgca acttaccact aaccaattct ttatttcgca 1616401 tagatcatct ttgtcatgtg tttacacaag aatctgtttt ggactgagac actgaatata 1616461 acaaaacagt caaaaatcaa tatttaattc attctgttta aactttctga aaaagatgtt 1616521 gaaaaagtcg aaaggatttt ataatattaa gtcaagttag tttgtttgat caacaaacta 1616581 atgaaatgaa ctttcattat ccacaagata agatcttact aatatggatg gaagggggat 1616641 aagagggtcg atttaatgga gctaaacaat ataagaaacg aaagaatgag gcttttatcc 1616701 ttttccaggt atataaggta tgacgaaaaa agatgaattt tttgcttgct gatcaccata 1616761 tttttttgca ctgttttgaa agcgctttta taaaagttta ctgaccgtaa attcgagaaa 1616821 ttgttatacc gtttcacact gttccatatt aaaggatcga aaaggggaga aatcatgctc 1616881 agtgaaaatg taaagaagat tagcatggtt gaaaaagttg gatatgcgtc tggagatttt 1616941 gcttgtaatt taatttatgc aacagtgtct acgtatcttt tgttcttcta tacagatgtt 1617001 tttggtttat cggcagcagc agccggtact atgtttttag tggttagaat aatcgacgct 1617061 ctcgctgatc cttttatcgg aacaatagtt gacagaacga acagcagatt tggacgcttt 1617121 agaccgtatc ttttattcgg agcttttcca tttgtcatac tggcaatact ctgttttaca 1617181 acaccagact tttcggatat ggggaaatta atatatgcct atataaccta tgttggcttg 1617241 tcgcttacat acacaacgat aaacgttcca tatggcgcgt taacttctgc aatgactaga 1617301 aataatcaag aagttgttag tataacttct gttcgcatgt tatttgcgaa tcttggggga 1617361 cttgtcgttg cattttttgt tcccttactg gctgcttatt taagcgatac ttccggcaac 1617421 gagtctcttg gctggcaact aaccatgggt attttgggaa tgataggcgg gtgcctttta 1617481 atcttttgtt ttaaaagcac aaaagagcgg gtcactcttc aaaaatccga agagaaaatt 1617541 aaatttacgg atatatttga gcagtttcgt gttaatcgtc cacttgttgt attaagtatt 1617601 ttctttatta ttatttttgg agtgaattcc atcagtaatt cggttggcat ttactacgta 1617661 acgtataact tagaaagaga ggatttggtg aagtggtacg gtttgatagg aagtttaccc 1617721 gctttggtca ttttaccgtt tattccaagg cttcatcaat ttttggggaa aaagaaatta 1617781 ctaaactatg cattattact gaatattata ggcctcttag ctttactgtt tgttccgcca 1617841 agtaatgttt acctcatact tgtctgtcga ttaatcgctg ctgctggaag tctcactgcc 1617901 gggggatata tgtgggcgct tattcctgaa acaattgaat atggagagta caggactggg 1617961 aaaagaatgg gtgggctcat ttacgctata atcggatttt tctttaagtt tggtatggcc 1618021 ttaggaggag ttgttccggg tctggttctt gataagtttg gatatgtagc aaatcaggca 1618081 caaaccccgg cggccttaat ggggatttta attacaacaa ccattattcc cgtgttcttg 1618141 cttgttctag ctttaattga tattaatttc tataacttag atgagaaaaa atataaaaac 1618201 atggttcgag aattagagaa tagagacaaa gtttatttgg atcatattga tgatttcaag 1618261 gcttaaaaaa gaaaataaac tgaggaggag tcccaaatga agattaccaa tcccgtactt 1618321 aaaggattca atcccgatcc aagtatttgt agagcaggag aggattatta tatcgctgta 1618381 tctacatttg agtggtttcc gggagtccag atacaccact caaaagattt agtaaattgg 1618441 cacttagttg cacatccatt acagagagtt tcacaattag acatgaaagg aaacccaaat 1618501 tcaggtggag tttgggcacc atgtttaagc tatagtgatg ggaagttttg gctgatctat 1618561 acggatgtta aggtagtaga tggcgcatgg aaagattgtc acaattattt agttacttgt 1618621 gaaacgatta atggtgattg gagtgagccg attaaattaa atagctcggg gtttgatgct 1618681 tctttgttcc atgatacgga tggaaaaaag tatttattaa atatgttatg ggatcaccgt 1618741 attgatcggc actcatttgg aggaattgtt atacaggaat attctgataa agagcaaaaa 1618801 ttaatcggta aaccaaaagt tatatttgaa ggaactgata gaaaactgac agaagctccg 1618861 catctttatc atatcgggaa ctattattat ttattaactg cagaaggagg aacacggtac 1618921 gaacatgctg ctacaattgc tcgttctgca aatattgagg ggccatatga agttcatccc 1618981 gataatccaa ttttaacgtc atggcatgac ccaggaaatc cattgcaaaa atgtggtcat 1619041 gcatccattg ttcaaacaca tacagatgag tggtatttag ctcatttaac gggacgtcct 1619101 attcatcctg acgatgattc aatttttcag cagagaggat actgtccttt gggcagagaa 1619161 acagctattc aaaaacttta ctggaaagat gaatggccct atgtagtagg tggaaaagaa 1619221 ggaagcttgg aggtagatgc accttctata cccgaaacaa tatttgaagc aacgtacccg 1619281 gaagttgatg aatttgagga ttcaacatta aatataaatt ttcaaacttt aaggattcca 1619341 ttcacgaatg aattaggttc attgactcaa gcgccaaatc atttacgatt attcggtcat 1619401 gaatcattga cctcgacatt tactcaggca tttgtagcca gacgctggca aagtctccat 1619461 tttgaagccg aaactgctgt tgagttttat ccggaaaatt ttcaacaagc cgctgggttg 1619521 gtgaattact acaatacaga gaactggacg gctcttcaag tcacgcatga tgaagaactt 1619581 gggcgcattc ttgaattaac aatatgtgac aacttttctt tttcacagcc attaaataat 1619641 aaaattgtta ttcctcgtga agtaaagtat gtatatttaa gagtaaatat tgaaaaggac 1619701 aaatattatt atttctattc ttttaacaaa gaagattggc acaaaattga cattgcactg 1619761 gaatcgaaaa aattatcaga tgattatatc cgtgggggag gattcttcac aggggccttt 1619821 gtagggatgc aatgccaaga taccagtggt aatcatattc cggccgactt tagatatttt 1619881 cgttataaag aaaaataatt tgcacatgaa aaaggagatt tctattttag aactcctttt 1619941 tcatatgaga aggtgccatg tcactattgc ttcagaaata ctcctagaat aaaaaaactc 1620001 atctttaaag atgagctgtc cattccataa aaaattacat tgtaatcatg tccagaaaat 1620061 gatcaatcac aatggaggac attcctaatg ccggtgcatt ctgtcctaag gaagatggca 1620121 ataattcata gctattgcct aattgggaat aaacccttga tgatacttca cttctcattg 1620181 aatttaaaac cataggatgc gattcaatta tgctatttct taaaattacg gcttgtgggt 1620241 tgaaagtatt tagaatattg gtaaggccta ttcctaaata gaatccaaaa ttttgtaatg 1620301 catttaaggt tccgatatca ttcagatggg cgaggtttat gatatcttga taggacagtt 1620361 ttttctcttt ggtctgaaga gattttaata aagccttctc tgaagcatac aattcccagc 1620421 atcctcggtt tccgcaactg catttaggac cattaaagtc tattgtcata tgtcccattt 1620481 ctccagagaa gccgcttact cctctatata aatgattgtt gataataaca ccgatcccta 1620541 ttcctgtgct gatacttacg taaataatgt tatcgtgatt ttttgcagct ccaaatactt 1620601 tttctccata tgcgccagca tttgcctcat tttcaataaa aacaggcaca ttgtacttct 1620661 cttgtatcga agattttaag tcaatatctc tccagttgga gttcggagtg aaaacaattt 1620721 tttgatcttt atcaatgagt ccaggcacgc aaatacctat accaataagc ccgtacggag 1620781 attggggcat ttgcgtaata aagtgatgaa tcatatcaat caaaatgtct ttcgttattt 1620841 ctggagaatt ggattccaaa tggcggtatt gatcaagaac gattgttcct tcaaggtctg 1620901 ttaaaatgcc attaatataa tccacaccaa catctattcc aacggagtat cctgcctttt 1620961 tattaaaaac aagcatgaca ggtcttcttc cgccacttga ttgtccttga cctatttcaa 1621021 ataccatact ttctttcatt aacgtgttta cctgtgatga gacagttgat ttatttaatc 1621081 cagtcatttc agataatttt gctcttgaaa taggtgaatt tttaaggatt tcttttaata 1621141 ataacttttg atttactttt ttgacaaagg tttgatcagc gatatccact tcatccactc 1621201 catttgttta atctttaaat taagtatcaa catagtacat agcgaatctt ccctttatta 1621261 tatctaatgt gttcataaaa aactaaaaaa aatattgaaa atactgacga ggttatataa 1621321 gatgaaaata agttagtttg tttaaacaac aaactaatag gtgatgtact tactatatga 1621381 aataaaatgc atctgtattt gaatgaattt atttttaagg gggaaatcac atggctcaat 1621441 ctcattccag ttcaatcaac tattttggaa gcgcaaacaa agtggtttac gaagggaaag 1621501 attcgactaa tcctttagca tttaaatatt ataatcctca agaagtaatc ggcggaaaaa 1621561 cgctgaaaga gcatttgcga ttttctattg cctattggca tacatttact gctgatggta 1621621 cagacgtttt tggagcagct acgatgcaaa gaccatggga tcactataaa ggcatggatc 1621681 tagcgaagat gagagtagaa gcagcatttg agatgtttga aaaactagat gcaccattct 1621741 ttgcttttca tgaccgggat attgcaccag aaggcagtac gctaaaagag acaaaccaaa 1621801 atttagatat gatcatgggc atgattaaag attacatgag aaatagcggc gttaagctat 1621861 tatggaatac agcaaacatg tttacgaatc cccgtttcgt ccatggtgcc gcgacttctt 1621921 gcaatgcaga tgtgtttgcg tatgctgcag cacaagtgaa aaaagggtta gaaacagcaa 1621981 aagagcttgg cgctgagaac tatgtatttt ggggcggccg tgaaggatat gaaacattgt 1622041 taaataccga tttaaaattt gagcttgata atttggctag atttatgcat atggcagtgg 1622101 attatgcgaa ggaaatcggg tacacagggc agtttttgat tgagccaaaa ccaaaagagc 1622161 cgaccaccca tcaatacgat acagatgcag caacaaccat tgcctttttg aagcaatatg 1622221 gcttagacaa tcattttaaa ttaaatcttg aagccaatca tgccacatta gccgggcata 1622281 cattcgaaca tgaattacgc atggcaagag tacatggtct gcttggctct gttgacgcaa 1622341 accagggtca tcctctttta ggctgggaca cggatgaatt tccgacggat ttatattcta 1622401 cgacattagc aatgtacgaa atcctgcaaa atggcggcct tggaagcggc ggattaaact 1622461 ttgacgcgaa ggtcagaaga tcttctttcg agcctgatga tctaatatat gcccatattg 1622521 cagggatgga tgcatttgca agaggattga aagttgccca caaattaatc gaagatcgtg 1622581 tgtttgaaga tgtgattcaa catcgttacc gcagctttac tgaagggatt ggtcttgaaa 1622641 ttatagaagg aagagctaat ttccacacac ttgagcaata tgcgctaaat cataaatcaa 1622701 ttaaaaacga atctggaaga caggagaaat taaaagcgat attgaaccaa tacattttag 1622761 aagtataaca ggataagctc cagatcctgc tatcaatacc aagtcactga attacccgtc 1622821 atgattcctt tcctattgct tgttgttatg acgggtaact tctataatta ggatttattt 1622881 agagtgaatg gttttttaaa agggcaagga gtgaaaaaat gaagtatgtc attggaatag 1622941 atcttggaac gagtgctgtt aaaaccattt tagttaacca aaacggcaag gtttgtgcag 1623001 aaacgtccaa aaggtatccg ctcatccaag agaaggcggg atatagtgag caaaatcctg 1623061 aagactgggt tcagcaaaca attgaagcat tggctgaatt ggtttctata tccaatgttc 1623121 aagccaagga tattgacggg ataagctatt cgggacaaat gcatggatta gtactgcttg 1623181 accaagatcg tcaggtgtta cgtaatgcaa ttctttggaa tgataccaga acaacgcctc 1623241 aatgtataag gatgaccgag aaatttggcg atcatcttct tgacatcaca aaaaaccgtg 1623301 ttttagaagg gtttacatta cctaaaatgt tatgggtaaa ggaacatgaa cctgaacttt 1623361 ttaaaaaaac tgctgtgttt ttgcttccga aagactacgt gcgattccgt atgaccggtg 1623421 tcattcacac cgaatactcc gatgcagcag gaactttact tttacatatt actcgcaagg 1623481 agtggagcaa tgatatttgc aatcaaattg gtatttctgc agatatttgt cctccgcttg 1623541 ttgaatctca tgattgtgta ggatcgctgc ttccgcacgt tgccgcgaag accgggctat 1623601 tagaaaaaac aaaagtgtac gctgggggag cagataatgc ttgcggcgct attggagcag 1623661 gtatcctttc ttccggaaaa acattatgca gtattgggac gtcaggggtc atactttcct 1623721 acgaagaaga aaaagaaaga gactttaaag ggaaagtcca cttttttaat catggaaaaa 1623781 aggattcttt ttatacgatg ggcgtcacgc tcgctgcagg atacagcttg gactggttta 1623841 aaagaacgtt tgcaccaaac gaatcgtttg agcaattatt gcagggggtg gaagctattc 1623901 cgataggagc caatggactg ctatacactc cttatttggt tggtgaaaga acgccgcatg 1623961 ctgattcttc tattcgggga agcttgatcg gaatggatgg agcccataat agaaagcatt 1624021 ttttgagggc aataatggaa ggtatcacat tctctttaca tgaatcaatt gagctattcc 1624081 gcgaagcggg aaaatcagtt catactgttg tttctattgg tgggggagct aaaaatgata 1624141 cgtggctgca aatgcaagct gatattttca atacgagggt aattaagtta gaaaatgaac 1624201 aagggccagc tatgggggct gcaatgctgg ctgcctttgg aagcggttgg tttgaatcac 1624261 ttgaagaatg tgcagagcag ttcattcgtg aggctgctgc attttatcca aaggcgcaaa 1624321 atgttcaaaa atataaaaca ctatttgatt tgtataagaa catttacact cacacaaagg 1624381 atctcaatac agctttgaag agctttcgaa aaaactaatg atgttattgt ctggagatca 1624441 accgaagaac aattaatgat caatcatcat caaaggcctt tgataacatg gctgccttct 1624501 tttgaaaaga tggtgagaat aaggtatcgc aacctttaaa cagtattgga gtatccagca 1624561 gacaaaacga acgagtggaa ccgtattttg tcagcgaaca cttcaagaag tggggaagct 1624621 taggaatgcc aatgggtaag atgtatgaaa ccgcgctaac gacggtagag ggatctcttg 1624681 atttatgaag aaataggaag gatgttaaca cacaaataac ccctcacatt gacgtgaagg 1624741 ggtgtttttt attgttacta tacagcggaa attttacagg ctagttgcat gattttagct 1624801 tgttaagcag aatggaacta gactctccat catctctttc tcattctttg gaaactgcat 1624861 tctgctaggt ttgctgcttt ttttaacaaa cagtgttttt ctatttcaca cagccattaa 1624921 atcctctgtt cgtcacataa ccgctcttac tccaaattga cagtttatct gattttgctt 1624981 cttgctcatc tagtctgaat tggtctatgt attttgtgtt aggctcatat acatatgcta 1625041 ctctggccaa tccctctttc aataatgtct cttgaacaga tttgccgtca acataaacgt 1625101 atgctaacag tcttccatac ttatctctgc gatcgccttt atcaaattcc agctgtagct 1625161 taccgctgtt gaccaattct ttatttcgtt tcgacgcatc ctcaccgtat ggttgaacac 1625221 aagaatttgg tttcttcgtc tcaggtgtat caacgagcaa gtagcgaact gtgtctttct 1625281 ttccgttgta aataacctta atcgtatctc catctattgc tctatctaat gtaacattga 1625341 ccaatttctt ctgatttttt gaatgaggcg tgccagcctt ttgttctgtc tgattatatt 1625401 cattagagtg agtatcttga gagacttgct ccgtcccatt agaatctgaa tggtttttgg 1625461 ctgcgtgatt tgatccgcaa gctgccaaag taatacttaa aacgattgcg atcatactga 1625521 tcaaaatctt cttcatattg attccctctt tatcattttc tcttttcgcg attaaacatc 1625581 atcattataa cgatatggac attttttgtg aatggaaaac ttcaagggaa cttataacac 1625641 tccaaattgc caatagttaa cttcacaacg agatgatcaa aacatcacca tcacatagcg 1625701 gaaataaata atcctgaaaa taatattgac tgaaaatgct tttagaatta tgataatatg 1625761 agaaatgaca ataatgtgac aaagacatta ctacaacata acaactaata gcttaggttt 1625821 attctattgg ttaaaaatgt aaacggttac aaatccagag gcgaaaatct aagatagaga 1625881 tgactttagt tttgactcaa tatccacact gaaagagctt attaagtatt cttaaaggca 1625941 ggggaaatgg atatgaatga acatcgaaat cgaaggttga aattaataat gatttcagca 1626001 acttttggag ggcttctctt tggatatgac accggagtta taaatggagc tttacctttt 1626061 atggcaaggc cagatcagct tgatttaaca cctgttacag aagggcttgt tacgagtatt 1626121 cttttattag gtgccgcgtt tggagcgttg ttatgcggaa gattggctga tcgatatggc 1626181 cgccgtaaaa tgatccttaa tctttccttt ttatttttcc tggcatcact gggaacagcg 1626241 ttagcaccta atgttttcat catggcggtc tttcgttttt tactggggct ggctgttgga 1626301 ggagcctcgg cgatggtgcc ggccttttta gcagaaatgg caccgcatga aaagagaggg 1626361 cgtatggtaa cccaaaatga actaatgatt gttggcgggc aatttttagc atatgttttt 1626421 aatgcgatcc tcggtgtaac aatggcaaat acgggacatg tttggagata catgctagtc 1626481 atttgtgctg taccggctat catgttattt gccagtatgc ttaaggtacc agaaagcccc 1626541 cgatggctaa tctccaaagg caaaaacagt gaggcgctgc gagttcttaa acaaattcga 1626601 gaagataaac gtgcagaagc tgaatgtaga gaaattcaag aagcggtaga aaaagataca 1626661 gcactagaaa aggcatcact caaggacttt tctacaccat ggctgcgccg tcttttatgg 1626721 attggaatcg gtgttgccat cgtgaatcaa attacaggtg tgaactcgat tatgtattat 1626781 ggcacacaaa tccttaaaga atctggtttt ggtacaaaag cggctttaat cgctaatatt 1626841 ggaaatgggc tgatatcagt tattgcagtt atatttggga tttggctggt cggaaaagtg 1626901 agacggcgtc caatattatt gattggtttg gcagggacga ctacagcgct cctattgatt 1626961 gcgattttct caattgtgct tgatggatct atggcacttc cttatgtagt gctttctttg 1627021 accgttttat ttcttgcctt tatgcaaggg tgtgtaggac ctgtgacttg gcttgtcata 1627081 gcggaaatat tccctcaaag gttaagagga cttggttctg ggataagtgt ttttttcctt 1627141 tggatattaa actttgtgat cggttttgct ttcccgatct tgcttagctc tgtaggtttg 1627201 tcttttacat tctttatatt tgtggcttta ggtgtattgg caatcggttt tgtgtacaaa 1627261 ttcatgccgg aaacaaaagg gcgtacactt gaagaattag aagagcattt tcgttctcga 1627321 cacgatcata atactcctga acaatcagtt attgaggtat aaatatgttg aaaatctctc 1627381 ttcttatagg agggattttt ttagtttcag aaaaaacaaa atccctctgg tagagggatt 1627441 ttgattcagc attttaagat gttctacacg tataatactg gagttgatac tttaaaaatc 1627501 tcgccatctc ttatataaaa acgagggatg cggcggctta atgtagacac gacttcatag 1627561 ttaatcgtat tgagcatttc agccacttca tcaacggaaa tctcggctcc tttttgctta 1627621 ccgtaaatca cgacttcatc tccttgttta ccttcaccgt tttctcctaa actgaccatg 1627681 atcatatcca ttgttactct tcccgccact ggcactcgtt ttccgcgatg aagaacaaac 1627741 ccgcgattgg aaagggcacg agaatagccg tcagcatagc caatcgggag tgtagcaatt 1627801 acttcattag gttctgcgat gtatgtagca ccatagctaa cggttcgggg ttctgtccgc 1627861 atggttttca cataagcgat gcgtgccttt aaacttaacg caggttcaag cttaacgaga 1627921 tttagttgtt taatataggc tgaaggatat aaaccatata agccgatacc taaacggatc 1627981 atatcagcgc taaattccgg aaatgcgata gctgcagccg tgttgcacat atgcacggtg 1628041 ggcagctcaa tcccctgttt ttttaaaaag ctgagaaaac tgatgaattt ttcatgctgc 1628101 agctttgtga gtgttgtgtc cggttcatca gctgtcgaaa aatgtgtgaa aatccctgtc 1628161 catctgagga atttacttgc ctttaaggct ttcactacct ctaaaagttc ttcctttgtg 1628221 cgtacaccta atcgtcccat gccggtatcc acgttaatat gaatggccag ccggttagca 1628281 ctcgcttctt tttccaatat ctcgtttgct tctttcatcc aatcaacctg aaatgctgat 1628341 aatgttatat tccaagctgc tgacttcttt acacaactaa gggatgtaaa accaagcaca 1628401 aggataggtg ctgtaatccc agctttacgt aaaacgattc cttcctccac actggcaaca 1628461 gcgagctcac tcgccccgtg ttccagtgca tggcgtgcca cttctataga cccgtggcca 1628521 taaccgttcg cttttacaac agccataatt ttgctcttat gtggaatatg acggcggatc 1628581 gctcgcaaat tctttttaac ggcatcaaga ttgacttcga tccaaacttc tcggcaaagc 1628641 tttatcatca acgcttcctt ccttcttatg gattataaat accacctatt gccgcaagaa 1628701 taaatgttaa ttgttggatg attcgatctt attttattca actttatttg aaatcattca 1628761 acagcaaatc catgtgatac gagaaggtgc ctatcaatgt tcgaataata gcaagtacgg 1628821 gatacatgag gcttgtaagt ggggtgttaa tggatgcggc gaccgaggat tacaaaaatg 1628881 attatttgtt ttgggacatt tttttctaag ggtagatgat aacgagaaat ctaatcagga 1628941 aatacttacc gttgttatga acattgaaga accttttaaa tgagaagggc tgaggaaatt 1629001 ctgtaaaaga taatcggttg aaaaggcagt cgattccttg ttccataaac ctaacatcag 1629061 agtatataat tatactcgta ttcacaaaaa tcgtttaagt aaggggtata catgaatagg 1629121 ggagttagtt ttcaaatacc gaatgaatat ggaaattttc tatggagaat actgcagccg 1629181 gtagaaatag ctaattatag gtggcaaacg agtggggaat cttattttgt tgtagaagga 1629241 gagctcgatg atgaggagct ttttcatgac tacgaaattg ttgagggggc agtttttgag 1629301 caacaattaa aaacgaatca gtactatacc attttcgttg aactgaaagc atttccatat 1629361 ggaaaaatgg ttaatcaagt caatacatat gaagagtttg ctgacagtga ttgcgaactt 1629421 gtccttttga tagcagataa tagctacgtt tcgatttact gtaaaaacaa aaatatcatt 1629481 gaaaaacttt acttcaatgc tttacagcat gattttgaag acgttcaatt tataactgat 1629541 gaaaatgaca caagaacaag ccttactgta tgatactcaa taaaaattaa aggagctagt 1629601 acatgacaat gcaaattaaa atcaagtatc tagatgaaac acaaacaaga atcagcaaaa 1629661 ttgagcaggg agactggatt gatcttcggg cagctgaaga tgtaacaatc aaaaaagatg 1629721 aatttaagct tgtcccatta ggtgttgcaa tggagctgcc tgaaggttac gaagcacatg 1629781 tcgtccctcg ttcaagtaca tataagaact ttggcgttat tcaaacaaat tcaatgggtg 1629841 ttatcgatga gtcatataag ggagacaacg atttctggtt ctttcctgct tatgcattgc 1629901 gtgatactga aattaagaag ggtgatcgta tctgccagtt tagaatcatg aagaaaatgc 1629961 cggcggttga attggttgaa gtcgagcatt tgggaaacga ggatagagga ggactcggtt 1630021 caacaggtac gaagtaaaca aaataaatcc ttggctgtct tcatgctgtg tgattgatca 1630081 atggaggttt cagccaaggt acatataaat attatgtata aaatgaatat tttaatacga 1630141 aggatttaat taaaaacaaa gtttaaaaag ggaagttttg aaaaagtgaa atagtaataa 1630201 ctaaagtcga taaagaacct aaagatgtca aagaaacaat ttttctggtg ctttgctttt 1630261 ttgaaggttt acttagctcg tggataactg ccccccataa aagcatggat gctaaaatta 1630321 taatacttat atacataaag atgctccttt tattatattt acagttttta catttttatc 1630381 gattttacca catttaggat tgagttgtcg atgaaacaag catctctata aagaaatact 1630441 tttatctaaa tttttataaa taggggaagg caactaaaaa ctagtaatgc cactaataat 1630501 aagccaagtt aaatgacttg tgttcattaa taattgaatt ttacagcagc catgagcaca 1630561 aaaaaatctg agttcgtcga taaatatcat aaaaaagccc ccggtatgtc gccagggaat 1630621 aaatagacgt ttaagagatt tagtgatgtt ttttatatga ttcgacaaaa tcataataat 1630681 gatcatcgtc atcataatac tttttttcgt aatgataatc gtgatcatcg taatactttt 1630741 tatcatggtc atcatacttt ttgtcgtaat cataatgttt tttatcatga tcataatact 1630801 tgtcgcaatc ataatgcttc ttatcattgt cgtaatactt tttgtaatat gtttttttcc 1630861 aagtataata ctcttcttta tattttttat aataacccaa ttaaattcct cctttatgtt 1630921 attcgaattt aatttatgaa gtttaaatga tatggtatgg tcaaatgaaa taagaatagt 1630981 aaaaagaggc tgtttaaaac actttctgaa aaacaaaacg gatagctgtt tatgaaaata 1631041 agagcgagag agagcactca atcactgtaa aataatagta aagtgtatag agagattagt 1631101 atacgtaaaa agggactttc tcattgaaga atatttgaac gttatggtta agattcaaga 1631161 gctctatgat gtgatttttc acactgcttt tgaaggattt agagttagac atcaaaaaca 1631221 aacagcaaaa ccggctagaa acagatcata taaggaatga accgctgcca aatatcataa 1631281 aaaagttgtt aatgatcaaa tgaatgaaat tagagagaat ttattttaaa gaaagcccaa 1631341 ttgcacatgg acaaatgaca attgatattg aggtaaaata caatgcatta aatcagaaaa 1631401 agctattgga ggatttaatg tgtttagaca atttccaatt tggtatacac aaacacctga 1631461 ctatttgaat ttttatgtac cgcaatatca aaccatttcg tataatcctc aacaatgtta 1631521 tcaacggtgt atgtaccaaa ctggcggtaa ctatgagcta tgtgacagac tatgttatgg 1631581 agaaatacag gtgtaaaaga gggggattaa ctcctcttta aacacacagt gagtggaata 1631641 agatcctcac tttatctgca agtgcttagt atttgcgata atattgcatt cgtaataaat 1631701 tatgcttagc aactgaaaat gaaagaagga tatgaatagt catgacgcaa ttcgataaac 1631761 aatacaattc aattataaag gatattatca ataatggaat ctcagacgaa gagtttgatg 1631821 taagaaccaa gtgggactca gatggaacac cggcacatac tctaagtgta atcagtaagc 1631881 aaatgagatt cgacaactca gaggttccga ttttaacgac aaaaaaggtt gcctggaaaa 1631941 cagccattaa agagttgctc tggatttggc agctgaaatc taatgatgtt aatgatttaa 1632001 acatgatggg cgtccatatt tgggatcagt ggaaacaaga agacggaacc atcggacatg 1632061 catatggatt tcagctgggg aagaaaaaca gaagtctaaa tggagaaaaa gtggatcagg 1632121 tagactatct tcttcatcaa ttgaagaaca atccatcttc acgcagacac attacaatgc 1632181 tgtggaatcc tgatgaatta gacgcaatgg ccttaacgcc atgtgtatac gagacacaat 1632241 ggtacgttaa acatgggaaa ctccaccttg aggtaagagc acggagcaat gatatggcat 1632301 tgggaaatcc attcaatgta ttccagtata atgtgttgca gcgcatgatt gctcaagtga 1632361 ctggttatga gcttggtgaa tatatcttta acattgggga ttgccatgtg tacacacgtc 1632421 atatagacaa tttgaaaatt caaatggaaa gagaacagtt tgaagcacct gaactatgga 1632481 tcaatcctga agtgaaagat ttttatgact ttaccattga tgatttcaag ttaatcaact 1632541 ataaacatgg ggacaagctt ttatttgagg tagcggttta atgctgcctt tttattgtgc 1632601 agtgaataga tagcaggtat cctaatttca ttaagcaatc tggaagatga ataaaaattg 1632661 aaggacaaac acgtataata cataaaaaag attaactcta cagttaatct tttttattca 1632721 gaagaaaata tcctaacttt gaaactaaat acaaagtaaa agcaatcatt acagttctag 1632781 atattacaat tccatgaata gctagatcat atccagcagg tatcaacgca tttgtattac 1632841 acataaaata tatagatatt agaagtgcta caataactaa aatcattcca aaaagacttg 1632901 ttttttcata tttcatacca atttccaccc ttattaaagt taggtttaaa caaaagagct 1632961 gaagaaacga actatgacca gtatgctcca aggaaaaccg ccagacaatg ctggcggctt 1633021 tttgctgctt cgtttattta ttaacagaga tcgtaacgtt atttcctgca actgaaacct 1633081 ttgcgaaatc ctgtgtatct accacaggag tgacggcttt attgtcgata gtgatgttgt 1633141 taaaagaggt cgaaaaggtt gctttgatcg catcacgctg gctttcatac gaaacagccg 1633201 cggtagcaag tgttttccat tttgaaatcg tgccgatgtt ggttccttga atttctgtga 1633261 taatccgtcc ggtgtagccg tcattgttcg ttccccaaag ggtcatgcgc gtattgccgc 1633321 ttaaattttt atagattgtc atttggactg tgcttccagg gcggaagcct ttattgtatg 1633381 tgaatttgtc ttttccttcg atgtacgttt cttcattttt ggacccaacc ttcatgaggg 1633441 gcttccagac gttgtattgt ttgctgtact gaagcccgat atcggcttca gttccgcttg 1633501 ttgccctaaa gccagaataa atatagggag tagagaccga gtcgttgttt ttgacagttt 1633561 caggaagcac gattttagct gtaaaaacgg cgcccgtact gttcaggtag acacggccgc 1633621 cgattccgtt aggcagctcg gatgctgctt ttgcgacttg agcgtctgcc gcgggtaaac 1633681 ctggtatacc tgatgaaagg gttccgaaaa gaactgctgt tcctactgca cctgcaatca 1633741 atactttttt caccaaaatt cccccttttg atagtggttt cgccatttat tataccttat 1633801 tttggaactg gatttacgta tataaatcga caaaatattt cattttgaat gatgtaaggt 1633861 cgaaacgctt cgccaatctg aaagctatat acctttatca gaggaaagaa tgagatcaca 1633921 ttcgttttaa ccgatttgaa attttcctca aaataaaagt acaaatgctt aaagaaacga 1633981 ttattaaaag aatgcccgct atcgtttcca agcctgtaaa aaagaggtga cgtttcatca 1634041 atgtctgtcc ttgtaaaatg ataaaagcac agataccgac taagaaaaga aaacaaatac 1634101 ttaggattgc taacgcttta cgtgagtatg ttttcatttc atctttaaaa tacagcaata 1634161 cgaaaataaa gcagataaca ttggctattg ttctaatcac ctcaaagctt ttcatgacaa 1634221 ctgatataaa tagacaaagt aaaatgagat aaaatacgat gtttctatac aaaaaacctc 1634281 tccttttatg taggatcctc aaagagttta taaaagtttc tttgtaactg caataaattg 1634341 aatgcgctca cttatgaact aactaaacta tgtactaaat attcactatt ctttttcaga 1634401 ttcagtcacc aaggttttca tagaaaggga agcttcagaa atatacatat agtgcacaaa 1634461 caaaaaagac ccggcaatag ccgggggaaa gtaaaaacga ggagatgtta atggcgttta 1634521 gtagtgtttt ttatgctttt tatactctac aacataatca tagtcttttt tatcgtgatc 1634581 ataatatttt ttatcatagt catcatattt tttgtcgtaa tcacagtcat aatctttttt 1634641 atcatattcg taatacttct tataatacgt ttttttgacc gtataatact cttctttgta 1634701 ttttttgtaa taacccatat atactcctcc tttattttta ctacgcttta ttatacggcg 1634761 agtagatttt gcggcttgga cagttaaaat catagaagga aaaaagggct gtccaaatga 1634821 tagaaaaaga cagatgacac aaaaacaaat caaaataaag agccgatttt tcatcggccc 1634881 aaacgattta tcctacattt gtttgtcttc tttgttttct gagtcatttt ttctgatatc 1634941 ctgagtcagt ccgcttgttg cttgtttaaa ttctgataag gcttttcctg ctgcacggcc 1635001 aagcgccggc agtttatcag gcccaaatac taaaaaaccc acaaacaaaa taacgagtat 1635061 ttttgtgaag cttaattcca tatccttttc cccctgattg aagtacaacc ttttaaacaa 1635121 attataagag atagcagtac aaatgggaat gcatttattt tgaacatttt aaaaccagca 1635181 caaagacgga ttcataaaac ggctgctgct gaatataatg tccaatgcca cctgcctaag 1635241 aagcaggagg caggctggat caattatgta gctctgccgg aaatgataca aacgtagcgg 1635301 ctatcattga catagaggag tggtgtagct gatgagattc actaaggtag ttggattttt 1635361 gtctgtttta gggttggctg cggtttttcc attaacggca caagcagaaa aagccggaac 1635421 tgcgggggct ggagagtggg ataagttggg gacttacaca tatacttact caagtccgac 1635481 ggtatactcg accggaggag attttagagt gtgcctttca ggaagcactc ctttttctgt 1635541 ttcactgcac ttatatgagg atgatcccgg tgacaatcct gatgattatg taggggcaaa 1635601 ctatttttca cccggagaat gccacacctt tggcagtatt ggaaaatttg tagatgggag 1635661 caataacaag gccgagttct ttgttaccga ttactctggt aaatctaaaa ctgttacgtt 1635721 ttatgattga tggactcaaa ttgtgaagta taacccttgg aaaaaaacaa aaaagagaga 1635781 tacctctctc ttttttattc ttcgacagcc ttacgaagcc gttcatttac aatgccagtc 1635841 cagccgccat ccatcttacc gcgaacgacg gagcttttct cgtttgcttt gccgatcact 1635901 tcattcggct ctttccagcc gctgtgaata agggtaaacc ctgtcttttc ccccaagtct 1635961 tctaattgaa aggtaacgac ccatccttct gtatcccatt caaaagaaag ttcagttgga 1636021 gcttgaacag ccaaaacttt acaaggggac ggcccaaacg gcgattgtaa gtgaaattct 1636081 tgtccttctt tgagctgaaa gtcattgggc ataaaccact tggcaatgcc ttctgaagta 1636141 gagactgtct cccagacttt ctgaatggga gcctccagag taatgctttt tgtaatatcc 1636201 ggtaatgcat tttcgttgtt ttgagccatt tcgtttacct cttgacatat gatgtttttt 1636261 caattcaatc atataataac taataagatc atgtccatag cgtgcattat ttatgctaga 1636321 gctgctgttg aacagcgtgt cagtcgccag tctgatctgt gaatgggaga attctgcatg 1636381 cgcgaaaaag agagagaggt gtatgttgtc atttcgttca ttcttgtttg cagccgcaac 1636441 tgttatgttt gaactgggat tcctgttcag ccaatttatt ttgcgatttt tgttttaata 1636501 gtaaatgagc cattttctaa aacaggaggt tttttatgct tggaaaaatc aaagcagcca 1636561 ttgataatag tccagggaag ccggccagaa ttttagttag tgaaaaagcg tttcagcaat 1636621 tagaggaaga aatgcgcttt gtttacgttt ccaaaccgaa aacgataatg gggattcctg 1636681 tggaagtttc agatcaggca gaaagcttca agctggaatt ttagttttcc cagactgcta 1636741 aaaggctcat tttgtgttaa ttatgcaaaa tggtcaggtt gatttcttta aaagcatgat 1636801 gaaatgttca tcatgctttt ttattgagaa aaaagacgaa cataaaaaat aggtatacgg 1636861 gaaaaataat cctattagag agaggggaac tgacagatgg ataacatgat atcaacactt 1636921 actgactgga atgtgtggtt tcaagcgtta gtagtatttc tcgttccata tgtaatctat 1636981 aaagtgttta cttggattca tgtataagaa ggtgcaatga tgaggtggcg gaacaatcag 1637041 tacaaaacac agaagcagca taaatcagat tattcgacag ctgaaaagca ggatcaggat 1637101 gtgttaaccg gtaacatcgg atacgactta gaacatgtaa aaagaaaaat aggacataac 1637161 ggggacgttc atttccgtga gcttgaaatc actcaattac atgtgaaagc ggcattgatc 1637221 tttgttgaag gactgtctga tcaggacttg attaataaag gactatcagt gttagtcatg 1637281 aatcaaccta atcaggtaag cgatgaaatt tctcaatccg gcaaaggtat tttaacttcg 1637341 aaacagataa aaaatcaaat cgtatcaatc ggtgatgtca tagattcaga gaaaatcagt 1637401 gatatcgtgt tgaatgtttt catgggttcg acagcgcttc tcatcgatgg aataccgcag 1637461 gcctttcttc tgggaactgt aaaaaaacaa aatcgaagta tcgaggagcc gctttcagaa 1637521 gcgcttgtca gagggccgcg cacaggcttt acagaagagt tgagtacgaa tacagctctt 1637581 ttgagacagc aaggaaaaaa tgatcaatta acattgcaga gatttgaagt aggaacacga 1637641 ttaaaaaagg atttaattat cgcttatatg aatgacattg cagatccaaa agtagtcgag 1637701 gaagtaagaa aaagagtgag agggattgag atcgatcatt tgccggagtc aggctacgtt 1637761 gaacagttaa ttgaggataa ttatttgagc ccgttcccgc aagtacagag tacagaacgt 1637821 cctgatcgcg tcataagcgg attaatggaa ggaagagtag ctattctgct tgacggcact 1637881 ccgtttgctt tgattgttcc agtcactttc agcatgatgc ttcaatcgcc tgaagattat 1637941 tatgaacggt ggttcccgag ctcgctcatc agattgctga ggttcatcgc agcaatgata 1638001 acgttattcg cacccgcttt atatatatca tttatttctt ttcatcctgg gttaattccg 1638061 accaagctgg cgatttcaat ttccgggacg cgccaaggtg ttccgttccc atctctgatt 1638121 gaagccttat ttatggaagt cgcgattgaa attttaagag aggcggggct tcgtttgcca 1638181 aaaccaattg gacccgcaat aggcatagtt ggcggattaa tcatcgggga agcagctgtg 1638241 caggcgggga ttgtcagtcc aatcatggtc attgttgttg cgctcacagc aatttcttca 1638301 tttgccatcc cgcattatag cacaggtata gcacttcgga tgcttcggtt tggcgcgatg 1638361 ttttgtgcgg cggtgtttgg attgtttgga gtcattatgt attatctgct gctaagcagc 1638421 catgtcgtaa agctaaagag ctttggtgtg ccatacgcaa gtccggcagt gccctatcac 1638481 ttaaaagatt ggaaagactt tgttatcaga atgcctcttt tagtcatgaa gcgccggcct 1638541 aaaatgatga atacagataa tacaaaacgg gtgaagtgat gaactcgaca ggatggtgat 1638601 aaagtctcat gttcagccca accagtaaaa tcacaaccgc tcaggcaacg attatcatca 1638661 ttaattatat gcttgctgcc ggagttctta cgctccctcg gacagtaaca gaacaaacac 1638721 aatctcctga tggatggatt tcagttttat taggcggggt cctagcggta atagccggga 1638781 tgattatagc taaattaagc cagcagtatc ctaaggagac cttttatgaa tactcccgac 1638841 atattgtagg aaaatggctc gggcatctga tcagtattgt ttttattact tattttctgg 1638901 cactcggtgc atttgaagtc agagtcatgt ccgaaatcgt ggattttttt ctcctcgaag 1638961 ggacaccttc ttgggccatc attatgacag ttctttggat tgggctttat tcaattacac 1639021 aaggcctaga tccgattgca cggctttttg aaatgatttt tccgattacg gtcatcatct 1639081 ttttaacgat agccctcatg agtttaggca tatttgagat caacaatttg cgccctgtat 1639141 taggtgatgg aatcatgccg gttcttagag gtgtaaagac aacgaacctt tcatttacat 1639201 gttcagaaat tatgttcatt ttagtagcat ttatgaaaaa gccgaaaaat gcggtgaaag 1639261 cagttgtgat cgggacaggc gttgtgacca gtttttatat gattacgatg attatggtca 1639321 tcggtgcact atcagttgag ggagttgtga cgagaacatg gccggggctt gacctgatga 1639381 gaagttttga aatacctggt ttaatatttg aacggtttga atcatttctg cttgtgattt 1639441 ggattatgca gctttttgcc acgtttatta tcacttttta tgcagcttcc ctgggagtct 1639501 cacaagtttt taaaaagaaa cccctttcat gtatgtttgg gctgcttcct gttatatata 1639561 tcctctcttg catgccgaaa aatgaaaatg acgtctttat attgggcgat acggtcagtc 1639621 atatcgcttt gtatatattt ggcgctttgc cgattttgct gttagtcatt tcgaaatgga 1639681 ggaaaagagg tgaaaagtaa actaaaacgt caattgcctg ctatggtcat agtatgtctg 1639741 ctgatgattt gcgtaacagg atgctggagc agtcgggaaa tagaagatct gggtctcaca 1639801 ttcgctatcg caattgataa aggaaaagaa acgaacactg aaaaagagtt aaaagaagag 1639861 ggcgggagct atccgaaaaa agacaacatt acgctgacct atcaatttgt taatgaaaaa 1639921 gcggcaggcg cgggcacaag cgggggaggc ggtagcggac aaggagcgca aaaagcgtac 1639981 attaatataa gtgaaacagg ggattcatta cagcagatcg gaagtgaggt tgcattaaga 1640041 cgggaccgag aagtgtttag cccgcattta aaagttgttg tcatgagtga agatgtgctg 1640101 cacacatttc ctatcgacga aatgctggat caattttttc gtgataatga aatcaggctg 1640161 agctgtcttg ttttatctgc taaaggggaa gcaagagacg ctctccagct gaaagagaac 1640221 ggagaaattc cggcatttcg gctgattgga ttaggtgaaa atgaacataa agtttccaga 1640281 attcttcccc ctatgacact cgcgaaacta attggaaaac tgcattctgg cagcagcttt 1640341 ttactgcaaa atgtggttgc ggcgaatgga gcggtcaagt attccggagc agctgtaatc 1640401 aacggaaaat cgaaaaaaat gataggcacc ttaaatgaat atgaaactga ggggattaca 1640461 tggattagag gagaagggaa aggcggagtt gtcaaaagtc atgataaaaa gagccaacag 1640521 acgttagcgt acgatatcaa taaaatcaaa agcagaattc agccaatcgt aaaagggaaa 1640581 gatatttcat tccatgtcga tattgaatca gaaggcgatt tggttgaaaa ctggaacaca 1640641 aaagaggcgt tggacaccca gtttatagat cgtctcgaaa cgactattga aaacgaggta 1640701 aagaaaatag ttggtcaggt attaaaaaaa attcagcatg attataaagc agatgttgcg 1640761 ggttttgatg aatcttttag acttacatat cctcacttat ggaaaagggt gaaaaataac 1640821 tgggatgaca ccttcagtaa agccgacatc acatacagtg tgaacgtcac aattactcat 1640881 ttcggcacgg ttaaaactca gtaatgaatc ccaaggaaga gaaggaaacc tctcttctct 1640941 tttttatgca tttattagga taaagatact ttttttggag agatatacac ttttcaaatc 1641001 gaccaatatg ctaatatagg aattgcttga aatagaaggg agaaggggct gtgaggcaga 1641061 aaccgattta tgtagaaatc gaaatgaaat ctgatctgga tacactctgg gaatatacac 1641121 aaaacccatc actgcataag gaatgggatc tccggttttc aaatattacg tatttgaata 1641181 gtcagccatg cgaaaaacag aagtttcttt acgaaacaag ggtaggcttt ggattaaagg 1641241 tgtcaggtac aggagaaacc gtcggtgttt tcaacaaatg ttcatctgaa aggtcttctt 1641301 cactggcttt tggctctgat catccattat ctctgattcg gcatggaagc ggctactgga 1641361 agtatataca gagagaaaat gggaaaatga cgtttttaac acagtaccaa tacaaaacag 1641421 cctacggact gctgggaaga tggattgatc gtttattatt tcggccgctg cttggctggg 1641481 cgactgcctg gagctttgat gcattaaggc tttgggtaga gcaaaataaa catccgaagc 1641541 gcttcattcg atctgctatc atctatgtgt tcatgtgtct gtttttcagc ctgttttggt 1641601 tctatcaagg ctttgcaggt gttaagacaa gcatattgac aggaacagcg gagataggct 1641661 tagctatttt gtggctgctt cctttaaaaa gaaaatggat cattcatggt gtccaggctt 1641721 gtatttttgc tgggtttgct tgtctaggtt ccgaaatatt catgtgggtt ctattgagtg 1641781 tgttttccgc tgcaagcggc gctcttagcc tgcagctccc cagtgccagg cgcacaaaac 1641841 gaaagagaaa gaagtgacat tgtgagttcg atttatgaaa aatcaattat taactatcat 1641901 ttgctgcatc ccaagctgca gaaacggtac caattagacg ggtctcatac attcagcggg 1641961 acgggaacga tgtcagaaat aagcggaggc tcttttctgg ttagaatgct gttaaagctg 1642021 ggtgtttttt tcagatgctt cttttcagaa agaggcaaag acattccatt tacaatacaa 1642081 aatagaactt gtcttttgaa atcgcaacat acaggaatag aatggaatcg tacatttttc 1642141 tttaaaggca aaaaacgttt ctttgatgcg ttaatgatat atgacgagaa agaaaataga 1642201 atacttgatt tcttcggcaa acctcatctg ctgctgtctg ttttgacgtt cgaggcatct 1642261 cttgacggct ctcttacgat cacatcggga aagcaatggc tattgatatg cggaaaaaga 1642321 atcccgctgc cgaaatggct gaccggtaca tccgaagttt gcgaaacgtt tgatgaaaaa 1642381 aagaattgtt tcaccattga agtgcatgtg caaaatacaa ttcttggcac tcttttcttt 1642441 tataagggaa cgtttcagga ggaagagaga gaatcatgaa acgaaatggc atagtcagtg 1642501 cgctttgttt tattggattt cttgcagcag aagcaccgga tatttcagtg gcagaggcac 1642561 tcgttttgtt atccattcta tttttcgtgc cgggaatttt tccttttgtt tttcgtcaat 1642621 ctccggttcg tgctgctcag tttatggaaa acgggctaat ccagtgctat cctgtagccg 1642681 cattctttgc ggtgctggct ctagtgacgg aggttggggg tttcgcactt atctggtgga 1642741 tgtacacagt ttttaatgca ttgtatgcga tcctccgcct ttgggaaaca aagatacata 1642801 gaatcgaaga gacatcagtt ttgttcggtc ttatttattt ggcgggagga ggattttggt 1642861 tttttgctta tgctgcccat ttgcagatca tgcaatttgg ccctctcatc attttgctga 1642921 ctgctgtcca ctttcactat tctgcttttc tgatcccgat cttcaacggt ttactcggca 1642981 gaaccattag aaaacatcgg atgttgtaca gttggataac atgggtgatt ttgctttcgc 1643041 cccttcttat cgcactgggc atcacatatt caaaaacact tgatgtcatt gcggttagca 1643101 tttatatggc ggcgatttat cttcatgcat ttttggtgtt cacggcagct tttcgcacca 1643161 agacggggac atttcttatt cggctttctt ccgctgtttt aatgataacg attgctttct 1643221 cgatgattta ttcatttggt gtctttcggc aagaagttac attgaccatc aatcagatga 1643281 tttggattca cggttttgtc aacgcgtttg gtgttatctt gcccgctctc atagggtgga 1643341 gaatagagga tgcgaaacct tttgatgcag acagtgtaaa gacattcagc cgtatctacg 1643401 gaaaaagaaa gattggagaa gaatttttag ctaacattca agctgaaaat aacgctcggt 1643461 acagcggact tgtggatgat atgggcagcc tgcgttcaaa agatttttca ccagaaaaac 1643521 tggcgccgct cattctttcg ttttatgaac aaaccatcga atacaatatt aaagcaaaag 1643581 taacatggag cacgtggttt cggccgcttg caattattta cgaatggttc agcagaagaa 1643641 tcggccaaat acatctttcg acgaaccctg actggtatag gatgtacagc aagataaaag 1643701 gtgttcattc gaaaaaagac ggaagggaaa gagtacgtgc ctggattaga acaaatgaaa 1643761 aaaacgaaac catttttacc gctctttatt cagtgtatcg ttcaaatgga gaggggtata 1643821 tgaatatttc tttaccgctt ccattcagca gcatgacagg tattttaaaa ccatatcatc 1643881 atcaggagaa gctggtttta acaagcaggc ggagaaaaag cagagcgggg gatgagggga 1643941 tttatctgca aacaagagcg ggaacttgtc cgcttccttt atctgaaacc tttctgatag 1644001 aagctgtaca tgacaacaaa ttaaccgctg ttcatcatat gtggctgttt ggaataaaat 1644061 ttctaactgt tcattacagc attacacata ttaaccagcc tattgaaaga acctaacaca 1644121 aagaagaagc ttcgtctgcc agttgtaatg agatgaactg ttttaaaatt ctgcaccgca 1644181 tcaagacagg aaaggaaggg tttatggtgt tttatatcag tttatttctg attctttggc 1644241 tggctgctgg gtttgcagtg ggaatgaaac aagtgtatgt cgatcagctg tttgataaag 1644301 ctgtgatcga aagactggaa aaagaagcga atgatcatgg acatgctgac cggatgatca 1644361 aacagcgcgt cctttatatt gcagcagtga cagtaagcgg gtttatttct gtttattatg 1644421 aaatgaaaac aatcccgcaa aggcgaaaca taagaaaaat tgaaaaaaac atcatgaaat 1644481 taaatcaagc aaaaaaacga agaatgaaga gaaaataaaa agtgcacagg ccaaagggca 1644541 ggtgcatttt tgttttgtat ggaaaatggg ggaggtggtg ccagcttact tttcataaat 1644601 tcaaaaatga gaagaacagc gcccgggcta atggtatata atattgtgaa tttaacaaaa 1644661 atttaacaag gaggacgaga gaattcgtgc taaagcctca aagagaccta cattctgttg 1644721 atttggactt agaggcggag tagatgaaac cggccaaagt atccctgctc cgccgtttgc 1644781 tccattcctt gaagcatgtt gattgtaaca tagccaaacg ttttccatca actattaaaa 1644841 ttgtaaaatt attgatgatt tttatggtgt ttactccgat ttcttcaatt tatgctgaag 1644901 atgtatatca gaattttgag gaattaaaaa acaatgaaga tccttctgat tatggcgttg 1644961 ttacgaaaga aaccggaagc cctgttcttg ttttagctat tcacggagga ggtattgaag 1645021 gcgggacaag tgaagtagcg agagagctca gcaaagagta ctcgatgtat ttatttgaag 1645081 gcttaaaatc ggcaggaaac tcagtcctgc acattacgag cacacacttt gatgaacctc 1645141 gggcccttaa aatgacggga aatcatgaat atgtcatttc attacacggg tacgcagaag 1645201 aagatcagca gatcgaagtc ggcggtacag atcgcgtaag agcggcagat ttagttgaga 1645261 aattgcagca tgccggtttt cctgctgtat tgctcaatat ggaccatccg catgcgggcg 1645321 ttagtccgaa taacattgca aataaatcaa aaacaggttt aagtattcag atagaaatga 1645381 gcacagggtt tcgaaagtct ttgttcggca tcttttcttt aaaaagcaga gctgttactc 1645441 aaaatgagag gttttatgag tttacagaag tgatgttccg ttttctcaaa aatagctact 1645501 gaaaaatagg aggcgataag acagcctcct attccttatg cttctctttc gtttcgggaa 1645561 acagctcgtc cgcggcttcc gtttgatact gcaacgtgtt atctctcgct gacagttcat 1645621 ttcggaaatt ttcatcaagc acatttttca gtaaataccg atgaaaaaag tattcaaaaa 1645681 cagtaagaca ggcagcggaa aggagagccg ctccaaatgg tgagaaatcg tttcttgttt 1645741 gggttaaaac aaatacccaa agaataacga atgaaaggcc aaagtcagcc aatgaagctg 1645801 taatattgtt tgttctgggt aagacgagca tgtcaccaga aagataggaa acaaaaccta 1645861 agaaaagtgc aataaacatc acacttaaaa aggatgcgtg atagactctg tccaaaatca 1645921 catataaaag ggcgagagtg aaagcaatct ttgaagcaag cgcaatgata tgtttcattt 1645981 gaccacctaa attgttattt tttgaagaaa attcttgggc gtaaacaaat gataaataat 1646041 gcaattcaaa accattcata atggtcatgt tactatttta aacagtccgt ttttgtttac 1646101 actggtattt ttttcagctg tatgaaactt tcttatgaaa aaagtcgtat atgtggatga 1646161 tcagctttca aggggggaat gatttgtgga gataaaagga atcaatcact tgctattttc 1646221 agtttcgcat ttggatacat cgattgattt ttatcaaaaa gtgtttggtg caaagctttt 1646281 ggtaaaggga agaacaactg catattttga tatgaacggc atctggctag cgcttaatga 1646341 agaaccagac atcccgagaa atgacattaa gctttcttat acccatattg cttttacaat 1646401 tgaagatcat gaatttgagg agatgtcagc taaattaaaa agacttcatg tcaatattct 1646461 gcctggcaga gaacgagatg aacgcgatcg aaaatcaatt tattttaccg accctgacgg 1646521 ccacaaattt gaatttcata ccggaaccct tcaagacagg cttcgatatt acaaacaaga 1646581 aaaaacgcat atgcactttt atgatgaaac ggccttttga tagcacaacc atatttcata 1646641 taaggttaaa tttaaagaag ggtgttggtg gagactttat gtttggggaa ggtttctacc 1646701 cgacttgttc aacgatgcca tatcttttga actgcacaag tgattgggtg aaggtgaaat 1646761 tgaaatacac attacattac attttatatg aagaaagcga gctgttttat caaatgttga 1646821 actaattaaa ctatgtacta aattttcagt atatttcaat tgctttgccc cttaataaat 1646881 ataaaaccgc atccttccac gacctaaaaa atgaaacgtt tttaagaaga tggcgtctaa 1646941 tattctaaat gttcatattt tgataaaagt ttcctaaagg aaagaaaatt tcttgacttc 1647001 aacaatcttt tggtggataa ttatggtgta aacatgatgt tctttttcct cctattcggg 1647061 ctcgcaccca aaagtcaggg cgagcctgct ttttttgaac aacaaacccc ctctccgtaa 1647121 aggaagaggg ggttatttta tgcatctgat agatcaatag attaatggac ggttctgaac 1647181 acgccaatca ctttccctag aatgctgaca ttctgcaaaa tgataggttc catcgttggg 1647241 ttctcaggct gcaagcgaat gtgggtatcc tctttataga atcgttttac agttgcttca 1647301 tcatcttctg tcatcgcaac tacaatttcc ccattgttcg ctgtgttttg ctgtttaacg 1647361 atgacatagt ccttatcgag aataccagca tctatcatac tgtctcccat aatctccagc 1647421 ataaatacat gctcgtctgg aggaaccatg cggtcaggga gcggaaaata ttcttcaata 1647481 ttttctactg ctgtaatagg agatcccgcc gtgactttcc cgatgaccgg tacattaacg 1647541 acctggcttt gcggaatgtc tacttcttca tcaagaattt ctattgctct tggttttgtc 1647601 ggatctcgtc tgatcagccc ttttgtttcc aaacgggcca aatggccgtg gacagtagaa 1647661 ctggacgcaa gcccgacagc ctctccgatc tctctcacgg aaggcggata tccttttgat 1647721 ttaacctctg ctttaataaa acggaggata tcaagttgcc tttttgatag cttcgtcatt 1647781 tttcgcacct caaaacgtcg attttaagaa gattatagca tgattttcct tacagtacaa 1647841 acataggttc gaaaaaacaa ttgacagaaa cgtttgttcg tatatactga aattataaaa 1647901 atgcgaacaa acattcctgt tggaggttat gatcatgagt aaagaatcta ttatttttgt 1647961 cggtctgttt acagtgattt tgagcgcggt tatccttatg ctgtcatata caagcagcgg 1648021 ccaagagctt aatcagtatg ttaaaataga agtccagcaa ggcgacacac tctggtcaat 1648081 tgctgatcag gtagccgata caaaaaagat aaacaaaaat gattttattg aatgggtagc 1648141 tgataaaaat caacttcaaa cctctgatat ccagccgggt gatgagttag tgatcccatt 1648201 gaaaaagaag catcaggatg catatgaatt agcaactgta agatagagag gaaagagaga 1648261 taaaatgaaa gcactcattt atgcccgtgt aagcacaaat aaagaacagc aggaaacgtc 1648321 attaaagcgg caggaggagg agcttacggc cattgcagcg gagaacggca tggaagtggt 1648381 caaagtgatt tcagaaaaag ccagcggata tgaaatggat cgggatggtg tatttgagct 1648441 gctcgatgag attaagaacg ctgatattga tgtcattttg gttcaggatg agacaaggct 1648501 cggacgggga aacgcaaaaa tcgcactgct tcattgtatt tatagagaag gtgtgaaagt 1648561 ctatacaacg gctcatagag gtgaactgga gttatcggag gctgactcaa tggtcttgga 1648621 aatcgtcagc attgtggaag agtatcagcg aaagattcac aacatgaaaa tcagacgggg 1648681 aatgaaacgt gcagtaaaaa acggttttaa accgcaaaaa aacttaaaaa accaacatgg 1648741 gaacagtgga aaagaaaaaa tagaggtgcc aatctcagag atcgtccgcc tgagagcgaa 1648801 taaactgacg tttgctgaaa tcgcggctac cctaagaggg tttggctatg atgtctctaa 1648861 agcaaccgtt caccggcgtt ttcaggaata catagagaat gaagagactg cagagtgaat 1648921 cagttgtaaa actttttttg atctagtact atatagacaa aatgcaataa aggagtttaa 1648981 catgatttca aacgcgaaaa ttgccagaat taatgaactt gctgccaaag ctaaagctgg 1649041 cgttattaca gaagaagaaa aagccgaaca gcaaaagctc cgtcaagagt acttgaaagg 1649101 ttttcgttct tctatgaaga acacgttaaa aagtgtgaaa atcattgacc cagaaggcaa 1649161 tgatgttaca ccagaaaagc taaaaagaga acaaagaaat aacaaacttc actaatataa 1649221 gaggaatacg gcaatatcgt attcctcttt tgcatatact ataatcaaaa ctcttatgtg 1649281 acaaaattca acaagtttct ctcaaattta agctgaaaca gttgagaaaa agtcgtcaga 1649341 catttatgat gtaagggtac aacacataag gaaggggatt tttatggata caattgaaaa 1649401 gaaatcagtt gctaccattc gcacactgtc aatagacgct attgaaaaag caaattctgg 1649461 tcacccaggg atgccgatgg gagccgctcc aatggcatac acgctgtgga caaaatttat 1649521 gaacgtaagt ccggcaaacc ctggctggtt taaccgtgac cgttttgttt tatctgctgg 1649581 acacgggtca gcactattat acagcatgct tcatttaagc gggtttgatc ttagtattga 1649641 agatcttaag ggattccgcc agtggggcag caaaacacca ggacatccgg aattcggaca 1649701 tactgccggt gttgatgcta caacaggtcc gcttggccaa ggaattgcca tggcagtcgg 1649761 tatggcaatt gctgaacgcc atttagcgga aacatacaac cgcgattcat ttaacgtagt 1649821 cgatcattat acatacagta tttgcggtga tggtgattta atggaaggta tttcttctga 1649881 agccgcttca ctcgcaggcc atcttcagct tggccgtctg atcgtactat acgattctaa 1649941 tgacatctct cttgatggag acctcgaccg ttcattctct gaaaacgtga aacagcgttt 1650001 tgaagcaatg aattgggaag ttctttatgt tgaggatgga aacaatattg aagaattaac 1650061 agcggctatc gaaaaagcac gccaaaatga aaagaaacct acattaattg aagtgaaaac 1650121 gacaatcgga ttcggttcac ctaaccgtgc cggtacatcc ggtgttcacg gtgcgccgct 1650181 tggtaaagaa gaaagcaaat taacaaaaga agcttacgcg tggacatatg aagaagactt 1650241 ctacgttccg tcagaagttt atgagcattt cgctgtagct gttaaagaat caggtgagaa 1650301 aaaagaacaa gaatggaatg ctcaattcgc taaatataaa gaagtttatc ctgaacttgc 1650361 tgaacagctt gaactggcaa tcaaaggaga gcttccgaag gactgggatc aagaggttcc 1650421 tgtgtatgaa aaaggaagca gtttggcatc ccgtgcatct tccggtgaag ttctcaacgg 1650481 acttgcgaaa aaaattcctt tctttgtcgg aggttctgct gacctagcgg gatcgaacaa 1650541 aacgactatt aaaaatgccg gtgattttac agcggttgat tactcaggca aaaacttctg 1650601 gtttggtgta cgtgaatttg cgatgggtgc ggccttaaac ggtatggcgc ttcatggcgg 1650661 tcttcgtgta ttcggcggaa ctttctttgt cttctctgat tacctgcgtc ctgcgattcg 1650721 ccttgcagcg ttaatgggcc ttcctgtgac atatgtcttc acacatgaca gtattgcggt 1650781 tggtgaagac ggtccgacgc acgagcctgt tgaacagctt gcttcactcc gtgcgatgcc 1650841 taacctttct ttgatccgtc cagcagacgg caatgagaca gcagcagcat ggaagcttgc 1650901 agtgcaaagc actgaccacc caacagcgct agtgcttaca cgtcaaaacc ttcctaccat 1650961 cgatcaaaca tctgaagaag cattggcagg agtagaaaaa ggtgcatatg tcgtttctaa 1651021 atctaaaaac gaaacacctg acgctcttct catcgcttcc ggatcagagg taggtcttgc 1651081 aattgaagcg caggctgaat tggcaaaaga aaatatcgat gtttctgttg tcagcatgcc 1651141 ttcaatggac cgttttgaga aacaatctga tgaatacaaa aacgaagtcc ttcctgcaga 1651201 tgtgaaaaaa cgtcttgcaa ttgaaatggg ctcatcattt ggatggggca aatacacggg 1651261 gcttgaaggt gacgttctcg gcatagaccg attcggtgca tctgctcctg gtgaaaccat 1651321 cattaacgaa tacggcttct cagttccgaa cgtagtgaat cgagttaagg cattaatcaa 1651381 taagtaagct tttgaaagag gatgagtcaa atcatcctct ttttcttgtt tatccgacaa 1651441 aaatagtatt ggctgtttaa cagtaataga caattctttc ttttcttctt ttgtataata 1651501 gagagcaaat gaaatgctgc tggaaaaggg gatgaaaaga tggaacgtca ctactatacg 1651561 tacctgatca aagaggaatt tgccaatcac tatttcggcc gggaatcggt tatgtttgag 1651621 ctgtttcaag actatcattg gacaagcctt gaaaagcagc agtatgaaat gacagagaaa 1651681 cagattcaat atattacaca accaatcccg attttacata tgcatcagcg gttaaaaatg 1651741 aatttaaaca agacggatta caggcagctg gattatattt atagaatagc tttgccgaaa 1651801 gcaaaaggcc acgcgacgtt tatgatgaag gagcacatga tagaaattgt ggcttcggga 1651861 gattacgagg cagaaacgat attctttgaa gtgttaagaa aagtaagccc ttgcttttta 1651921 gcaatggatt tcaattcgaa gcgttacgga tggctaaatc cggtgaaaga aagaaatttt 1651981 gtctaaaacc gaagaaaaag agatgtaaat gttgtataat agcttttggt ttagtacact 1652041 ttaaactaga caacatgaag gaggaaataa aatgacttta tgggttggca tcctagtggg 1652101 cgttgttgca ttgctcatag gtgttgcact cgggtttttt attgctcgta aatatatgat 1652161 gagctacctg aaaaagaatc cgcctattaa tgaacaaatg ttacgcatga tgatgatgca 1652221 aatgggaatg aaaccttctc aaaagaaaat caatcaaatg atgaaagcca tgaataatca 1652281 aacgaaataa tacgtaaaga ttatgatata gagaaacatg gttataaaat aaaaaaccct 1652341 tatacgggtt ttttattttg caatcattca tcacccgcta ctgctcgaag gcgctgcttt 1652401 tgatattgta tgagaagatg gtcaagctcc tgactgagct ctatcgtaat atgagatgtc 1652461 attccgttcg ccatgacaat ttgcagcagc tctgctcttt ttttttcaat ttcttttaat 1652521 agatgctctc taatcacagg gatgtatcct ttcatacatt agatcttcaa agtgaatgtt 1652581 tatattatat ccatatttat actaattttc aaatgagaag gagtataatg tctcaatgtc 1652641 aaattaaatt atataagttt tttctgaaaa tagaaatcct tcaagtgaaa gtgttaaaaa 1652701 aatgaaatga ttttgtcata acttgaagga atgtcaaatc atgaagggat gatgacatgg 1652761 gagacgtgaa ttattttttg acattcggag cggggttttt atcctttatt tcgccttgct 1652821 gcctgccgct ttacccagct tttttgtcat atattacagg ggtcagcatg gacgatgtaa 1652881 aaactgaaaa gctgctgctg cagaaaagaa gcttgtttca tactttgtgt tttttgcttg 1652941 gcttttcagt catttttatt gctttaggct atggaacatc ttttattggc agcctgttta 1653001 gggattatca cgatgcgatt cggcaaattg gcgcgttgct tattattttg ttcggtttca 1653061 ttacactcgg tgtgttccgg cctgaggcta tgatgaaaga gcggagaatc cattttaagc 1653121 ataaaccaag cgggttttta gggtcggtct taatcggaat ggcatttgca gctggatgga 1653181 caccatgtac cggtccgata ttagctgctg ttatcacact tgcaggcacc aatccgggct 1653241 cagcggtgcc atacatgatg ttatatgtac tcggttttgc ggtaccgttt cttttattgt 1653301 ctttttttat cacaaagctg aagtggataa ggaagaacca gcttttcatt atgaaagctg 1653361 gtggcgtttt gatgattgtg attggtgtgc tgttattctt taattggatg agcctgatca 1653421 ttattttgct gtcagatctt tttggaggct ttactggttt ttgacggtaa attactttcg 1653481 tactactact aatccttttg tttttggtac aataagacta ttatctgtgg aaatcgattg 1653541 ttggagggga atatgacaag agttttagtt gtagacgacg ccaagttcat gagagtgaaa 1653601 atcagagaga tcttggaaga ggcaaattac ataatcgcag gcgaagcggc ggacggtgaa 1653661 caagcagctg acctgtataa aaaactgcgc ccggaccttg tgacaatgga tattacaatg 1653721 ccggtgaaaa acggcataaa agcgcttcgt gatatcttaa cctttgatcc taaagcgaag 1653781 gtcatcatgt gcaccgccat gcgccagcaa agaattgtaa cggaagcaat tgagctgggg 1653841 gcaaaggatt ttattgttaa gccgtttgag gaaacaaaag tgctggaagc tgtaagccgc 1653901 gttatgggac attaaagtca tttcttttca aaatggtttt ttttattgtt ttggagtata 1653961 gtatatagta tcaacactcc gagaaacaaa ggaatgataa gtatgatgat tatagtttca 1654021 tcaattattg ctgtgttaat ggctgtagct gtgatggtgg tcagaataaa gtcctctgac 1654081 aagcctgttt caccaaaaaa aatcattctt ccgccgattt ttatgagtac gggagcgtta 1654141 atgtttttat ttccggtatt ttgggtaact ggagcagagt ttttggaagc attcacttta 1654201 ggtgtgattt tctctatttt tctaatcaaa acttctaagt tcgaaattaa aaataatgaa 1654261 atttacatga aacgctctaa agcatttgtt tttatattag tcggtctttt ggtgatcaga 1654321 atcgtgatga aatcgatctt gagcacatca attgattatg gtgcactgag cggaatgttt 1654381 tggattctgg ctttcggtat gattgtgcct tggagaatcg ccatgtattt atcatatcga 1654441 aaacttcata acgagctgca gtcatctaat attcaaatga attaaaaaac ctttcctctt 1654501 gtcaggaaag gttttttatt tgagaagggt ctgataaggt tccaaatcga tttttttgtc 1654561 ccgcagatgc ctttttaaga aggtatggtc tcttttagga gttgcgagaa tatagccttt 1654621 gatcataagt tgctgatcaa tctttgctac cttttctttt aatgcaagct caccgatttt 1654681 gcctgcgatt ttagcttttg ctgcatctct gaacagctct ggcacgggcg cagtcaattc 1654741 atctagaaac tgtttgtttt catcgttcca taaatgtctg ctgttttcaa tatagtaatc 1654801 ctgccaatca agctctgatc tgccgtcctc ttttggtaaa cgctttaaaa actttcgaaa 1654861 catgaaaaaa ccgccgattg ataataagac taccatcatg attacccaaa acagaataaa 1654921 ccataaaaac catccttcca gcatcaatca ttccccctta ttctaaccat attgtatacg 1654981 aagagagatt agaagaacac agtaaaaaaa gaatagaaaa aagtgataga cgtctagtca 1655041 aaagagatag tagatcatat tctattgtat agtgaatctg ctatttggcc atgggagagt 1655101 cactagaggg tatttgacga taaatggacg gaaaaaaagt cactttcata ataggggatg 1655161 aaagtgactt tttatgttta gctgagagga aattgaagag aaaaagaaga gccatcttct 1655221 gtttctttat tgacggcgac tgtgagtatt tgattttcgc attcgacttg aatgtttttg 1655281 tcattaaaat aaaaaggaag catcatttgt ttttcaaaag tctgtcctga cgatttgaca 1655341 gttaagatga actcgcatcc agaaagggta actgttactt gtgtaggctg taaaaaagtc 1655401 agatccgctt ctataatata ctgctgactt gtttcatata aatcaatagg caatgtttcg 1655461 tcgtaccagg cgaaggggtc ttcaaaaaat tgccgaagcc attcatccat actatcgaaa 1655521 tcattcgcat cgttgcgttt tgaatggttc atggaagcat tcctccacat atcaaccttg 1655581 ctttacatca tatgcggtgg attataaatg ggtgaacgca taaaaaaaca gacactaagg 1655641 tctgcttttc ttacatatca tggcttgagt tgtgcttttg tcttgtatgg tttcggtttt 1655701 ttactttttt gcttccgctt agaggctcgg gttggccggg attgtgtcct ttaggggcgt 1655761 ttttatgcat atctttactt gtattcttat tggtcataaa atgagaacct ccttaaaaga 1655821 gttcggtgtt attgattggt ttttcttttt ttgttatttt ggcgttctgc ttcagtcagt 1655881 acaagctggt cgttttcaat atagccggcg cctttgcctt ggctttttgc gtcattcatt 1655941 ccgttaatga cgtgattcgc ttttcttttg accatcatta tcacctcaat cataatatgg 1656001 cttcttttat tgtgttatat gagagagcgt aaacagtaaa aattaccggt acatttttct 1656061 cataagtcga acttattgta tttaataaaa acattgatat ttacttatgt atgattttgt 1656121 tttaatatga aattgtgaga aaattgtgat ggaatgtaat gttcatctga gaatgatctg 1656181 atctgaaggg ggattttgga gaatggcaaa cgagcaaaaa actgcagcaa aagacgtttt 1656241 ccaagcgaga aaaacgttta ctacaaatgg gaaaacatat cattactact ctttaaaagc 1656301 gttagaagat tcaggtatag gaaaggtttc gaagcttcct tattccatca aagttctttt 1656361 agaatcagta ttgcgtcaag ttgacggctt cgttatcaaa aaagaacacg tggaaaattt 1656421 ggcaaaatgg ggaactgccg aattaaagga tatcgacgtt ccgttcaaac cgtctcgtgt 1656481 tattttacaa gacttcacag gggttccggc agtagtagat ctggcttcac tgcgtaaagc 1656541 aatggcagct gtcggcggag atcctgataa aatcaaccct gaaattcctg ttgatctcgt 1656601 tatcgatcac tctgtacagg tagataaagc gggtacagaa gatgcattag cagtaaatat 1656661 ggacttggaa ttcgaaagaa atgcagagcg ctacaaattt ttaagctggg caaagaaagc 1656721 gtttaacaat tatcaggcag taccgcctgc aacaggtatt gtgcaccagg tcaaccttga 1656781 gttcttggca agtgttgtcc atgccattga agaagacggc gagcttgtaa cgtatcctga 1656841 tacgcttgtc ggaacagact cacacacaac aatgattaac ggtatcggtg ttctcggctg 1656901 gggtgtcggt ggaattgaag ctgaagcggg aatgcttgga cagccttctt acttcccagt 1656961 tccagaggta atcggcgcga aacttgtcgg caagcttcca aacggaacaa cagctactga 1657021 cttggcgtta aaagtaacac aagtgctgcg tgaaaaaggc gttgtcggta aatttgttga 1657081 attcttcgga ccgggaattg ctgaactgcc gcttgcagat cgcgcaacaa ttgcgaatat 1657141 ggctccggaa tacggtgcta catgcggatt cttcccagta gatgaagaag cgcttaacta 1657201 cctgcgcctg actggccgtg atcctgaaca tattgatgtt gttgaagcat actgcagaag 1657261 caatggcttg ttctacactc cagatgcgga agaccctcaa tttactgatg tggttgaaat 1657321 tgacctgtct caaattgaag caaacttatc gggtccaaag cgtcctcagg atttgatccc 1657381 gctatctgct atgcaggaaa cgtttaaaaa gcaattagtc agccctgcag gtaaccaagg 1657441 attcggttta aatgctgagg aagaaaataa agaaattaag tttaaactcc ttaacggcga 1657501 agaaacagtt atgaaaacgg gtgcgatcgc cattgctgcg attacaagct gtacaaatac 1657561 atcaaaccca tacgtgctga tcggcgccgg actggtagcg aaaaaagcgg ttgagttagg 1657621 gcttaaggtg cctaattacg tgaaaacgtc acttgcaccg ggttctaaag ttgttacagg 1657681 atatcttgtg aattcaggcc ttcttccata catgaaagag cttggcttta acctcgttgg 1657741 gtacggctgt acaacatgta tcgggaactc aggtccgctt tcaccggaaa tcgaagaagc 1657801 ggttgcgaaa aatgatcttc tgattacgtc tgtcctttcc ggaaaccgta actttgaagg 1657861 acgtattcac ccgcttgtta aaggcaacta tcttgcttca ccgccgcttg ttgtggcata 1657921 tgcgctggct ggaacggtaa acattaactt aaaaaccgat ccaatcggtg tgggcaagga 1657981 tggtcaaaac gtatacttta atgatatttg gccgtcaatg gacgaaatca atgcacttgt 1658041 taagcaaact gttacgccag agctattccg caaagagtat gaaacagtat ttgatgacaa 1658101 caagcgctgg aacgaaattg aaacaacaga tgaagcttta tataaatggg ataacgattc 1658161 aacttacatc caaaacccac cattctttga agagatgtct gttgagccag gcaaggttga 1658221 gccattaaaa ggactgcgtg ttgtcggtaa attcggcgat tcagtcacaa ctgaccatat 1658281 ttctcctgcg ggggcaatcg gaaaagatac gcctgccgga aagtatttgc aagaaaaagg 1658341 tgtttcacct cgtgacttta actcctacgg ctcccgccgt ggaaaccatg aagtcatgat 1658401 gagaggaaca tttgccaaca ttcgcatcaa aaaccaaatc gcaccgggta cagaaggcgg 1658461 atttacgacg tactggccga ctggtgaagt aacatccatc tatgatgcat gcatgaaata 1658521 caaagaagat aaaaccggtc ttgtcgtatt agcaggaaaa gactatggta tgggatcttc 1658581 acgtgactgg gctgcaaaag gaacaaacct tctcggcatc agaacggtca ttgcagagag 1658641 cttcgaaaga attcacagaa gcaatcttgt attcatgggt gtgctgccgc ttcagtttaa 1658701 acaaggtgaa aatgcggata cactcggctt aacgggtaaa gaagtcatcg aggtagatgt 1658761 tgatgaaaca gttcgtcctc gtgaccttgt gactgtaaga gcaatcaatg aagacggcaa 1658821 tgtaacaact tttgaagcag tcgtccgctt tgatagtgaa gttgaaattg attactaccg 1658881 ccatggcggc atccttcaaa tggtgcttcg tgaaaaaatg aagcagtcct gatgaatcaa 1658941 taggaagaga aggcatttcg ctttctcttc tttttatgac acaatgtgct gcggaggtgg 1659001 catatgctga aaaaatggct cgcagggatc ctgcttatca tgctagtcgg ttatacggga 1659061 tggaatttat atcaaacata cagcaaaaaa gaagtcggaa ttcaagaggg gcaacaagca 1659121 cctgattttt ctttgaaaac gctatcagga gagaaaagct ctttacagga tgcaaaaggc 1659181 aaaaaagtgc tgctcaattt ttgggcaact tggtgtaagc cgtgccgtca ggaaatgcct 1659241 gcgatggaaa agctgcaaaa agagtacgcc gacaaacttg cggttgttgc ggtaaatttc 1659301 acttcagctg agaaaagtga gaaacaggtc cgagcgtttg ctgatactta tgacttaacg 1659361 ttccccattc tgattgataa aaaagggatc aatgctgact ataacgtgat gtcatatcca 1659421 acgacatata tcttagatga aaaaggtgtt atccaagaca tacatgttgg caccatgaca 1659481 aaaaaagaaa tggaacaaaa actggatctt gattagattc agtttttttt atactcaaat 1659541 atgcttacaa gttttcagaa ttggaaaaaa taaaagaata tgcggaggtg agaagcgtga 1659601 agaagatgag aaaacgttct tttcatgagc tcgtcatgga aaacaaaaaa gagctgatga 1659661 ccaatacaga gtatttaaat cagcttgagg aaaagcttga acagcgattt aagcaaaaat 1659721 aacctttaat ttgtattcat gtttacccct ccttttgaga aacctatctg ttgaggaggg 1659781 ataaacatgg gaaacaacaa gaaaaacggt cagcctcaat atgctccaag ccacttgggt 1659841 acaaagcctg taaaatataa agccaataaa ggggaaaaaa tgcatgatac ttcaggacag 1659901 cggccgatta tcatgcagac aaaaggcgag tagcgaaaat tcgagtttat ttctaggagg 1659961 tacatccgaa tgacaaagaa ccaaaatcaa tatcagcagc ctaatcctga tgatcgttct 1660021 gacaatgtgg aaaaattgca ggatatggtt caaaatacaa ttgaaaatat agaagaagca 1660081 gaagcatcaa tggagtttgc ttcaggagaa gataaacagc gtatcaaaga aaaaaatgca 1660141 aggcgcgaac agagcattga agcgtttcgt aatgaaatac aggacgaatc tgcagcgaga 1660201 caaaacggat accgttctta aaaaaccagg gaaacctggt ttttttcttt ctgatttgat 1660261 tatggtaaaa tggggctaaa ttgacgttaa gggagcagag taatcttgca tgtatcaaaa 1660321 aaagaaatag aagtgcgtta tgcagaaaca gatcaaatgg ggattgtcta tcacgcaaat 1660381 tatcttgtgt ggatggaggt cggcagaacg gccttgatta aggacttagg ctttttatat 1660441 agtgatatgg aaaaaaaagg cgttctgtcc ccagtcgttg atatcaatat ttcctataaa 1660501 aagccgcttc attacggaga aaccgcggtt gtacatacat ggatagagga ctataacgga 1660561 tttaaaaccg tctatggtta ccacatttat aatccggccg gtgagctttc catcaaagcc 1660621 acctcatctc atatttgtgt ggataaagaa agctttaagc caattcaatt ccgcaaagct 1660681 tttcctgatt ggcacacagc atatgaaaag gccaaaaaat agggaagtga acgggatatg 1660741 gcgtttggtg tgaaacggga ggaacttaac cggtggaaac aagcagtgaa aagaggagaa 1660801 atcgcatttt taacacatta ctggctggat gaccgatttc cagaagcaaa gaccgtgaca 1660861 aaagccggct gtgcagacat tgataagctg gttcagtggg gagcggcgta cgggttaaaa 1660921 aaagaatgga tccataagaa aagtgaattt ccccactttg atctgctggg ggaaacacaa 1660981 aaatatattt tggaacaaga aaacctaacc gatcatctta tacgatttca tttgtaaaaa 1661041 aagaacgcac atgaagtgcg ttctttttta ttggtattca aaaaccggtt catcagcgtc 1661101 ttctgaatag ctgacgagaa ggtcgtggtt atcaaagtac cataaatcac tttcttcaat 1661161 aaagaaggta atgccatcag cttctgcagt gactccagcc tcttgtgggg catctttcgc 1661221 tacaccgaga gaaaaaccct tttgaacgtt gctgcagcct ccatagcgga cgaaaaagcg 1661281 aacctggtct ccgctttcca aatcgagttc ttctttatac cagttcaatg cgtcttcgtt 1661341 aattgtcata ttcataacag aacacccctt tgttcttcat ttgaattttc tctattataa 1661401 acgtattagg ctattctgtg tcaaaagaga agttttttaa gcttataacc attttacttt 1661461 aggttctgtt ttattgataa ttcgtttaat gttcgctcgg tgtctgtata tcacaaaaat 1661521 agtgagcagg gtaacgacaa tcaataaata cgtatcatgg acaaagaaac tatatataac 1661581 agtatagatc cctgttaaca tcgatgagag agaaacaaat ttagtcaagt ataaaaagat 1661641 gaagaatacc gcaaccatcg tgataaataa caggggtgcg taaaatagca aaacgcctcc 1661701 tgatgtcgcc acggctttac cgcctttaaa tttggcgaag atgggaaaca cgtggcctaa 1661761 aaccgcaaag actcctgcaa gaagcgggtg aatatcaaca tgcatgagaa aaggcaatgc 1661821 agttgccagt gtccctttca aaatatctcc ggctatgacg accgaaccag cttttacacc 1661881 caatgtacgg aatgcattgg tagcgcctaa gttgccgctt ccgtgctccc gaatatcaat 1661941 tcctttggca agcttgccca caattaagcc agatggaatg ctgcctatca agtaggccaa 1662001 aataatcaat aaagcaatta acatctacat ttctcctttt tcaaattccc ttctttttat 1662061 tttaacatga gatgtcatga tctgatgata agtttttttg taaagtttgc ttacaaatca 1662121 aatcaaacat gcatcatatt ttgatttctc ctgttttgat cgtgtaaaat aagtgaaaaa 1662181 ggagtgacac acgatgcaaa acccttctaa agcggaaatt aaagagattc ttcaaagaag 1662241 caaacgtata gcggtagtag ggctttcaga ccgtccggat agaacgtcac atatggtttc 1662301 aaaagcaatg caggacgcgg gttatgaaat tatccctgtg aaccctacaa ttgatgaggc 1662361 gctaggtgtc aaagccgttt catctttaaa agagatagac ggtccgattg acatcgtaaa 1662421 tgtattccgg cgctcagaac agcttcctgg agtggcggaa gagtttttag agacagatgc 1662481 gccagtattt tgggcacagc aagggctagt taatgaggaa gcataccaga tgctaaaaga 1662541 aaaaggcaga acggttatca tggatctgtg cataaaagtg gcacacgctg taacaaaata 1662601 ggtgcagaac tgcaaaaatc cttgtaaatt caaggatttt tgctttttaa ttttaagata 1662661 ttgtttgcgt attacggtga aacagataca ataaagcttg aacagctttt tttgaatacc 1662721 ttgtccagct gggtttcggc cgttcgattt gcgaaggtct gctgctttat atataataaa 1662781 caaacatacg ttctcatagt gtaaaaacag cactagccga tgttttgaga agaactgatt 1662841 cgttagctct atgttgcgat tgcaaacata ttggttataa tgaggagtcc aaggcagtac 1662901 tggctcgagg cgaggtttat aaaaaatatc ttatatacaa atgatgtgta acactgaaaa 1662961 gagaaagaca atgttagttt ttgaaagggg tttgtacgtt tggctagaaa acagcaattt 1663021 gattacaacg aagatgccat acaggtgctc gaaggccttg aggctgtcag gaaaaggccg 1663081 ggtatgtata ttggctctac tgacgcgcgg ggtttgcacc acttggttta tgaaattgta 1663141 gataactctg tcgacgaggt gcttgccggc catggagatc acataatcgt caaaatacat 1663201 aaagacaata gtatttctgt acaggataga ggccgcggca tgccgaccgg aatgcataag 1663261 ctcggcaaac caacccctga agtgatttta acggtgcttc atgccggagg gaaattcggc 1663321 caaggcggct ataagacaag cggcgggctc cacggagttg gtgcatcagt cgtgaatgct 1663381 ttatctgaat ggctgacggt taccattgag cgggacggtt ttgtctatca gcagcgattt 1663441 gaaaatggag gaaaaccggt tacatctctc gaaaagatcg gcaaaacaaa aaagacggga 1663501 actcttacac actttaagcc agatccaacg atgttcagca caaccactta taattttgaa 1663561 acgctctctg agcgcttaag agagtctgcg tttttgttaa aaggactgaa aattgagctg 1663621 attgatgaac gcaatgacca gcgtgaggtc ttttattatg aaaacggcat agaagcgttt 1663681 gttgcttact taaatgaaga aaaagacgtc ttgtctgaag tggtctcgtt tgagggtgag 1663741 catcattcta tagaagtgga ctttgcgttc cagtttaacg atggttattc tgaaaatatt 1663801 ttgtcgtttg tcaacaatgt cagaacaaaa gacggcggga cgcatgagtc aggtgcaaaa 1663861 actgcgatga cgcgtgcttt taatgaatat gcgcgaaaag tggctttgct gaaagaaaag 1663921 gataagaacc ttgaaggcac cgatataagg gaagggcttt cagccattat ttctgtccgc 1663981 attcctgagg agcttcttca atttgaggga caaacaaaag gaaagctcgg taccagtgaa 1664041 gcaagatcag cggtggatgc gattgtttca gagcagcttg cttacttttt agaggaaaat 1664101 cgggacaccg caacgcttct tgtcaaaaaa gcaatcaagg cgagccaggc gcgcgaagcg 1664161 gcacgcaaag cccgtgaaga agcaagaagc ggcaaaaaac gaaaaaaatc agaagcgact 1664221 ttaagcggaa agctgacgcc tgcgggttca agaaacccgg caaaaaatga attgtatctc 1664281 gttgagggag attcagcagg cgggtcagcc aagcagggac gagaccgcag attccaggcg 1664341 gttctgcctt tacgcggtaa agtcattaat acagaaaaag ctaagcttgc tgatatcttt 1664401 aaaaatgaag agatcaatac gatcattcat gcgatcggcg ggggagtcgg ggcagatttc 1664461 tcaatcgatg acatcaacta cgacaaaatc atcattatga ccgatgccga tactgacggc 1664521 gcccatattc aagtgctgct tcttaccttt ttctatcgct atatgaaacc gctcattgag 1664581 catggcaagg tgttcattgc gctgccacct ttatataagg tcagtaaagg aagcgggaaa 1664641 aaggaaatca ttgaatatgc atggtctgat gaagagatgg gggatgtcct gaaaaaagtc 1664701 ggcaaaggct ataccattca acgatataag ggtcttggag agatgaacgc agaccagctg 1664761 tgggaaacga cgatgaatcc ggagtcccgc acacttgtta gggtcaaaat tgacgatgcg 1664821 gcacgtgtag agagacgtgt gacgacgtta atgggagaca aagtagagcc gcgcagaaag 1664881 tggattgaga aaaacgtcgc tttcggctta gatgaagaaa gcaatatttt agaaaatgaa 1664941 aacttatcgg tcgctgagga ggtttaatga ttgtcacagc cagaattatt tcatgattta 1665001 ccattagaag aggtgatcgg cgaccgtttt ggacgctaca gtaaatatat tattcaagac 1665061 agggcgctgc ccgatgcgag agacggatta aagccggtac agcgcagaat tctgtatgca 1665121 atgcatacag atggaaacac gtttgataaa aacttcagaa aagcggccaa aacggtcggt 1665181 aacgtcatcg gtaactatca tccgcacggt gacagctcgg tttatgaagc aatggtgcgg 1665241 atgagccagg attggaaagt tcgtaatgtg ttaatcgaaa tgcatggaaa caatggaagc 1665301 atcgacggag atcccccggc agccatgcgt tatacagagg cacgattatc tccgatagca 1665361 tctgagcttc ttcgggatat tgacaaaaac acggttgaat ttgtgccgaa cttcgatgat 1665421 acaagcaagg agcctgtcgt actcccggcg atgtttccta acctattggt caacggatct 1665481 accgggattt cagcaggata cgcgaccgac attccccctc atcatctggg agaagtcatt 1665541 gatgctgtca ttaagcgtat tcaaatgcct tcttgctctg ttgacgaact catggaagtt 1665601 attaaagggc ctgattttcc gacaggcggt attattcagg gcgttgacgg gataagaaaa 1665661 gcttacgaaa ccggaaaagg aaaaatcatt atccgcggaa aggctgaaat tgaaacaatc 1665721 agaggcggac gagaacaaat tgtcattact gaaattccat ttgaagtaaa taaagcaaac 1665781 cttgtaaaaa aaatggacga gttccgtatt gataaaaagg ttgaaggcat ctcagaggtt 1665841 cgtgatgaaa cggatcgaac agggctgaga gtggtcattg aactgaaaaa agaagctgat 1665901 gccaaaggca ttttgaattt cttatataaa aatactgatt tgcagatcac atataacttc 1665961 aatatggtgg ctatccataa ccgccgtccg atgctgatga gcctgccgtc tattttggat 1666021 gcatatatcg gacaccaaaa ggaagttgtc acaaaccggt ccgtttacga gcttcaaaaa 1666081 gcaaaagaca gacatcatat cgtagaaggg ctcatgaaag ctttgtctat tttggatgaa 1666141 gtgattgcaa caatccgttc ttctagcgat aaacgtgacg ctaaaaacaa tttgatcgcg 1666201 aaatatgaat ttacagagcc tcaggctgaa gccatcgtgt cattgcagct atatcgttta 1666261 accaataccg atatcacagc gcttaaggaa gaggcagaag agctcggtaa aaaaattgaa 1666321 gagctcgaat ctattctgag caatgataaa aaactgctaa aagtgattac aaacagctta 1666381 aaagcactga aaaagaaata tgcagatacg agacgctccg tgattgaaga aaaaattgaa 1666441 gaaattaaaa tcaatctcga agtcatggtt gcatctgagg atgtatatgt aaccgttacg 1666501 aaggatggtt acctaaaacg gacgagccag cgctcatttg ccgcttccaa cggtcaggac 1666561 ttcggaatga aagatacgga caggatgctg catcagtttg aaatgaatac gacagacgtg 1666621 ctgctgctct ttacgaacaa aggaagctac atctattgtc ctgttcacca gctgcctgat 1666681 atcagatgga aggacatggg ccagcatttt tcaaatctaa tcactattga ccgtgatgaa 1666741 acgattgtaa aggctatacc gataaaagaa tttgatccgt cggcatatct tctattcttt 1666801 acgaaaaacg gtatggtgaa aaagacagag ctcactcatt ataaagcaca gcgttattct 1666861 aaggcacttg tagccttaaa tctgaagggt gaagatgaac tgattgatgt acatgtaaca 1666921 aatggggaaa gccagatctt tatggccact cacttagggt atggtctatg gtttggagaa 1666981 gacgaagtga atgtagttgg cgcgcgtgcg gcaggtgtca aagggattaa cttaaaagag 1667041 gatgactttg ttgtctccgg tgagattctt cagcaatctg attcaattgt cttgttcaca 1667101 cagcggggag cggttaaacg catgagtctt tctgagttcg agaagacatc ccgtgcaaaa 1667161 cgcggtgtcg taatgctaag ggaactgaaa aagaatcctc accgtgttgt agcactgttc 1667221 gcttgcggtc ttgaacagcg actaatggca gaaacagaaa aaggcgacag aaaagaactg 1667281 cagacaaaag agttgcggac aaacgacaga tacagcaatg gctctttctt ttttgatgaa 1667341 gaggaatcag gcaaggttac agctgtttgg cgccttcata cagaacaata ataaaaaacc 1667401 cgctcatact atatgagcgg gtttcgtttg ttttttatca gctttcatgg ttggtgaata 1667461 gatctgttac agcatgaatg acttcaatcc cctgccatac aaataaattc agcgctgtga 1667521 aagaaaataa gcctaaaatc accattctta agataaacaa catgtttaac agcctcctca 1667581 tattttcgtt acataatcgg gtgatgttga acatgaagtt tgccgaaata agacgattga 1667641 taaaatttgg ccagtataaa gctttttttc cgctgacgtc tgcgggagta tcccgtactt 1667701 ttgctttcag cggtcagcag cagaacagcc attgcccata aagcggtcag cgtaaatgcc 1667761 cctgtgatgg atttcttctc atcatcagca ttttggccgg ctttcatctc atgcatttcc 1667821 tgctggtcgg ctacggcttt ataatgatgg ccgatatcaa aggcgtgggg aattgagaac 1667881 aaatgaaaac tggcaatcgc caagaataag atggatgctt tcaatatcgt tacttttttc 1667941 aaatgatctc cccctccttt aatattactg aatattttta taataatacc ccaatccatc 1668001 ctaaaagtaa acctgattta ttaaatttaa aaataaattt aactttgtta agtatatatc 1668061 tttttgctta tttttgaaag agaaaacttc ttttattagc gtatgtatac ccggtttatg 1668121 gtgtgaataa aaacatattt taaatgatat gttgtttagg atttattact ttatttatgt 1668181 gtaaatcaaa gagaaaggca agagaatggg aagaaatgat tacattgtta atagggtact 1668241 ctttttttaa agccagtttg caaggaatgt ttttattcgt aggaaaataa tagagaaggg 1668301 gtcgacagag taacatctgg ctatgacaat attcttctcg aaaaaacttc ctaattcgtc 1668361 atattgtgat ataataaaac tcgttatgtt aaaaaatcta acatcaaaat cgaattcgta 1668421 ttgaattgat gaaaacggga ggtaaatatg gagtcttttt tcaatagttt gattaatatt 1668481 ccaagtgatt tcatctggaa atacctattt tatattttaa tagggcttgg attatttttt 1668541 accatacgtt ttggttttat ccaattccgt tattttattg aaatgttcag aatagtaggg 1668601 gagaagccgg aaggaaataa aggtgtttca tctatgcagg cattctttat ttcggccgca 1668661 tcccgagtcg gcacagggaa tttgactggt gtagccttag caattgcgac aggcggacca 1668721 ggcgctgtat tttggatgtg ggtagtggct gcagtaggca tggcttcaag ctttgtcgaa 1668781 agtacattag cacagcttta taaggtaaga gacggggagg atttccgcgg agggccggcc 1668841 tactatattc aaaagggtct tggtgccaga tggcttggca tcgtttttgc aatcttaatt 1668901 accgtctcat tcggcttgat ttttaacgct gttcaaacaa atacaattgc tggagcattg 1668961 gatggcgcat tccatgtaaa taaaatagtt gtagccatag ttctggcggt tttaactgcg 1669021 tttatcattt tcggcggttt aaaacgtgtt gtcgctgttt cacagctaat tgtgccggtt 1669081 atggcaggca tttatattct tatcgcttta tttgttgtca tcacgaatat tacggctttc 1669141 cctggcgtta tcgctacaat tgttaaaaat gctttaggtt ttgaacaagt cgtcggcggc 1669201 ggaataggcg gcatcatcgt tatcggtgcg caacgcggac ttttttcaaa cgaagcagga 1669261 atggggagcg caccaaacgc ggctgcgacg gctcatgtat cccatccggc aaagcaaggc 1669321 tttattcaaa cattaggcgt atttttcgat acatttatca tatgtacgtc cacagcattt 1669381 attattttgc tgtacagtgt aacgccaaaa ggcgacggca tccaagtcac acaggctgct 1669441 cttaaccatc acattggagg ctgggcgccg actttcatcg cagtcgcaat gttcttgttt 1669501 gcattcagtt cagttgtcgg caactattat tatggcgaga caaacattga atttattaaa 1669561 acaagcaaaa catggctgaa catttaccgt atcgctgtta ttgctatggt tgtgtatgga 1669621 tctttatcag gcttccaaat cgtttgggat atggcggacc tctttatggg tatcatggcg 1669681 ctgatcaact taattgtgat tgcgctgctg tcaaacgttg cttacaaagt gtataaagat 1669741 tacgcgaaac agcgtaagca aggacttgat cctgtgttta aagcgaaaaa catcccaggg 1669801 ctgaaaaacg ctgaaacatg ggaagatgag aaacaagaag cataatataa atataaaaca 1669861 aagctgcatt caatagttga atgcagcttt ttcattattg gaaataaatt taatttttcg 1669921 actcgaatga aaaatgacgt gtaaagtccc aattcagtcc agttttcttt gttctatatg 1669981 tgtcatgtgt gtcttattca ttggaggtag agcaaattga caggctttta aacctcccca 1670041 aaacaagaaa ttaggttgat agacaatcat gagaaagatt tttacaatga gttcgtgctc 1670101 ataagaagtg tagagccaaa atgatgcgaa ggaggaaaag atcagatatg aaacggtcaa 1670161 tctctatttt tattacgtgt ttattgatta cgttattgac aatgggcggc atgatagctt 1670221 cgccggcatc agcagcaggg acaaaaacgc cagtagccaa gaatggccag cttagcataa 1670281 aaggtacaca gctcgttaac cgagacggta aagcggtaca gctgaagggg atcagttcac 1670341 acggattgca atggtatgga gaatatgtca ataaagacag cttaaaatgg ctgagagatg 1670401 attggggtat caccgttttc cgtgcagcga tgtatacggc agatggcggt tatattgaca 1670461 acccgtccgt gaaaaataaa gtaaaagaag cggttgaagc ggcaaaagag cttgggatat 1670521 atgtcatcat tgactggcat atcttaaatg acggtaatcc aaaccaaaat aaagagaagg 1670581 caaaagaatt cttcaaggaa atgtcaagcc tttacggaaa cacgccaaac gtcatttatg 1670641 aaattgcaaa cgaaccaaac ggtgatgtga actggaagcg tgatattaaa ccatatgcgg 1670701 aagaagtgat ttcagttatc cgcaaaaatg atccagacaa catcatcatt gtcggaaccg 1670761 gtacatggag ccaggatgtg aatgatgctg ccgatgacca gctaaaagat gcaaacgtta 1670821 tgtacgcact tcatttttat gccggcacac acggccaatt tttacgggat aaagcaaact 1670881 atgcactcag caaaggagca cctatttttg tgacagagtg gggaacaagc gacgcgtctg 1670941 gcaatggcgg tgtattcctt gatcaatcga gggaatggct gaaatatctc gacagcaaga 1671001 ccattagctg ggtgaactgg aatctttctg ataagcagga atcatcctca gctttaaagc 1671061 cgggggcatc taaaacaggc ggctggcggt tgtcagattt atctgcttca ggaacattcg 1671121 ttagagaaaa cattctcggc accaaagatt cgacgaagga cattcctgaa acgccatcaa 1671181 aagataaacc cacacaggaa aatggtattt ctgtacagta cagagcaggg gatgggagta 1671241 tgaacagcaa ccaaatccgt ccgcagcttc aaataaaaaa taacggcaat accacggttg 1671301 atttaaaaga tgtcactgcc cgttactggt ataaagcgaa aaacaaaggc caaaactttg 1671361 actgtgacta cgcgcagatt ggatgcggca atgtgacaca caagtttgtg acgttgcata 1671421 aaccaaagca aggtgcagat acctatctgg aacttggatt taaaaacgga acgttggcac 1671481 cgggagcaag cacagggaat attcagctcc gtcttcacaa tgatgactgg agcaattatg 1671541 cacaaagcgg cgattattcc tttttcaaat caaatacgtt taaaacaacg aaaaaaatca 1671601 cattatatga tcaaggaaaa ctgatttggg gaacagaacc aaattagtta agcttttttt 1671661 tggcggacat cagtaacgat gtccgttttt atcatctaat aggaggtttg cgttgtggat 1671721 gaaatactga aacagtatat ggtgctgtat aaaaaaatga gtaatatgat aaatggtccc 1671781 gactatccag gtaaggaaaa agacatccag catcaaaaag atcagatcga agtttacgaa 1671841 aaacagctgc agcaaggatt ttctacagat tatgactatg atgtgtttgc tgattctgtt 1671901 atcaaatgcg catatggcga tatgacgctg gaagatttag aagccgttta ttatggattg 1671961 acaacaccat ttttttgatt tgtcattcag cagtaaaatt tcaatttctg tctcactaac 1672021 ttaagtatac tttgatattg agacagaaat ttatttattt tgtttacttc ctagaatata 1672081 tattatgtaa actagaaaag atgaagaata aagctttgct gtttttatgt acatcctttc 1672141 ttcttcctgt aattcagcaa caaaataaaa aagcgatttc ccaatcggaa aatcgccaat 1672201 tcagacactc tattatttat gtgtgtcttt gtgctcttaa cgatttacaa caaatgttgt 1672261 cacgctttga gctggaagat gagcccaaaa atgattgcct gatacagtga gattcgttcc 1672321 aggttgtaga ttgctgctgc tgctcgtgat ccatctagat acgtttgaag cagatccatt 1672381 ctgcaaaaca aagttttggt tgactcctgt gttgctttta ttgatggcaa caataacgac 1672441 cttgttgtca cctttatagg ctgacacgta aacgttcgca ttagggtttt tcgttgcatc 1672501 aatccttaca tagccgggac gcacaaactt tgagaaatga gccatattgt agccgcgttt 1672561 gctgatcgta ccatcttctt tcataggtcc atatgatctt cggatgtacc accatacata 1672621 agcttgaaag tccccctcta ccatcgcatt gtgaatatgc tgtgaaacat ccaatgcctc 1672681 aggccatcga tccgccgagt tggtatcact gtttggatag tatacttccg tcatccaaag 1672741 gtccttcccc gctccttttt gtttgaaaag aggataaggg aattggctga cctgggtgcc 1672801 gtacaggtga gttccgagaa tatccatatt ggcaagagcc tgcggatcgt tcaagatcgg 1672861 gtccgacaaa ttcttcaagt attgaaatga ctcaggcgca atgacgcggg cattgatcga 1672921 gccggcgttt tctctcataa agcgaagtat ttcttgcggc gtccaccacg tccactcgtg 1672981 agcgtaatca ggctcgtttt ggaccgaaat cgcgtaaaga ttcacaccat tattcttcat 1673041 gaaggtaaca aaatcgttaa gatgctgcgc gtatgctgcg tacttgttgt atttcagccg 1673101 tttagccgat gtgtcaccat tccgattaaa ggtctcaacc atatcacttg gaggattcca 1673161 aggagaagca aaaacgattg ctccgtgttt gaccgcactc tttgcagtct ccacctcttt 1673221 ataccaatta tttcgatttt catctacatg aattcttaag attgaaaatc ctaactggtt 1673281 ctgtccattg ccaaaagcag tttctctttg agctgctgta agatccccag cccaagccgg 1673341 atgattcatc cctccaaaac cgcgaatcac ttgtttctct gcagatacat taactgttac 1673401 atcacttgct gccaaaactt cagtagcgcc tggccctaac atgactgaca gcatagtgaa 1673461 acatactaat agtacacaaa ttgttttttt tatgcgtgga atcatttatt cctctccttc 1673521 gtcatgtgtc ttttacggta ttaaaaaatc tgcatggcat atccataatg gcgggctgtt 1673581 ccggtgctgg cccgtacttc acccgcctcg tttttaagcg gtcccattac gagtactatc 1673641 tttgcgtaaa ctgccagtaa tcaaaattaa acaagtttcc tgtacctgtt ccggtaaata 1673701 caaagaatac tttgtgcaca ccggttgccc cgcttaccgc agtttctatt tccctccacg 1673761 tttgcgctcc gcctgttgaa ggcacattca gagttccaac aagcttaccg tctgcactgt 1673821 cgaggcgcac ttctattttc ccgcctaaag tggatgctac atttgcttta aatgacctgg 1673881 caccgcccgc tccgaagtct gcatttccta cagcaatcca gtctccattt tgaatgcttg 1673941 ttacatgctg attatttact ggcccgccgg gtgctgtgga cttctctgtc aaaatgcgtc 1674001 cattccaagc aaacgtttca gcttctaccc ggttatatgg gtttaaattg gaaatttgtg 1674061 ttacacctgc ataatttgcc gctacctctt gaatagatcc atctgcatta tgcaccagct 1674121 tattaatatg gggagagcgg tatcctttgc cggccccgaa cagagcggaa ctgacagttt 1674181 gcgcatggta caccacatac cactcgtttt taaaattgaa aacagcatga tggttgtttc 1674241 cgccacctcc gaaaaatgca cccggatttt tcaggaagtg ccctctatat gtaaagggac 1674301 ccatgggact tgaactggtc atgtagccga tctcacccgg gggtttatcg gccgggtgcg 1674361 tgccgccgaa attgatgcaa taggagtaat aatatgttcc gttatacttg tgcaatcccg 1674421 aatcttcaaa catgaaaggc gcatcaattg tagatgcact tccaacaaca ctcgtcatat 1674481 caggccccaa ttttatgact ctagccgttt taggattggc ccattgtccc tgcgttggat 1674541 ttgaaacgcc aggaacgcct ccgccggcat acaggtaacc ggttccgtcg tcatctacaa 1674601 atactgccgg atcaaaaagc catacaacac cagacattcc tggcgtactt ggcgttacga 1674661 gcggttttcc gattgggtcg gtccatggac caatcgggct gtctgcggtg agaaccccga 1674721 tacctccgcc gctgtttgcg aaataaagga agaatttatc cttgccatta atttttttaa 1674781 ctgcgattga cggtgcccat gacgcacctg cccattttgc aattccacgg cctccattag 1674841 ctccattggc acctgctacc ggaatggctc cgtggtctgt ccagttcacc atatccgctg 1674901 aagatatgac gaatactcta ttcaaattgg caaatgaatt atctttaatt gttccgttgc 1674961 tattatattc atagtcatca cttgacatat agatgtagac tcttccgtta taggtcagcg 1675021 caaccggatc cgctcccaaa tgatggtcga taagcggatt tgaattccct atatgttttg 1675081 caattgtagt actagtggca gcatacgcag acttcccaga taagcagctc aataataaaa 1675141 ctagaatcca taaacatacg ctacactttt tcctcatcac ttcacatcct cctttttcct 1675201 taaaatgggg gattttcttt tggaatttga taacaacagg tcacgaagat tgcacgcata 1675261 aagtagccgg aagctgttta gcaatgttcc cagttgttct gaaagctcat cttcatgtgt 1675321 ctccattctc tcttttcttc gaggagatcg caccactcct tcaaaattgt tcaaaaaaac 1675381 ttccccattc ctagcgacca ttgtccagaa aataaaaaga caggattgtt catggcctcc 1675441 cactaatcac attgaacgga gattacatca ttatccaaga tatcccttta tctaacatcc 1675501 tacatcatta aaaaaattgt gtatagaaac ttttggagga gttagtgttc gattctacaa 1675561 aggaactgga tacatttatt cattgataag atggggctaa cactccgttt atatttgtat 1675621 gttttcagac acaaaaaaca gccgttcaat gcggctgttt ttttcaagag tataagacta 1675681 ttgagcggta tacccgcttt ttcatgtttt gttcatattt tattaattgt ttattcaaca 1675741 ctgtccgcta tagtaatcca tatcaacaaa tatgactgcc actcgcatct tttatgaagg 1675801 gaggttcgtt acgctgaaag aaaaaataaa gacattaggc cgtttttgca ccgtaggcgt 1675861 cggcaatacg ctgatagatt ttggtgtctt ctttcttctt accgcttgtc atgtctctta 1675921 tctgccggcg cagatctgct cctatactgc aggtatcgtc aacagctatg tgtggaaccg 1675981 gaattggacg ttttgtgtga aacgtaaggc tgacgggaaa gagatcgtgc gttttctcat 1676041 gattaatatt gccgcgtcag ggatcacctt tttgctgctt tatttgtttc aaaattgcgg 1676101 ctgctcgctt ttggtgagta agctcgccgc cactatcggc ggaatgatga tgaattttat 1676161 cggaaaccga atctgggtat ttggagattc gctgaaaaac atacaggatc aggagtgaag 1676221 atgaatgaga aaaaaagtga gaaaagcggt tatacccgca gcgggtttag gaacgagatt 1676281 tctgccggcg acaaaggcgc agcctaaaga aatgcttcca atcgtcgaca aaccagcaat 1676341 ccaatatatt gtagaagagg ccgcagagtc aggaattgaa gatatactga ttattacagg 1676401 gagaaacaaa cgctcgattg aagatcattt tgatcggtcg gcggaattgg aattcaatct 1676461 ccgggaaaaa ggcaagacgg agacacttaa ggaaatgcag cagattgccg atttggccaa 1676521 cattcattac atccgccaga aagaaccgct cggattaggc catgcggtgc tgtgtgcgga 1676581 gcattttatc ggagatgagc cttttgctgt tctcttaggt gatgatatta tggtgtctga 1676641 aacaccggct cttcggcaat taatggatgt atatgacgtt tatggcacag aggttgtcgg 1676701 tgtacagtca gttctccctg aggatgtcag caaatatggt attataaata catcagggtc 1676761 tcaagggcat gtatatgaag tgaacgattt agtggaaaag ccttctcctg aagaagcacc 1676821 ttcggaaatc gcagtaatgg gacgttatgt gctgaattct tcgatcttct ccgttttgaa 1676881 gacaattggc agaggcgcgg gcaacgaaat tcagctgaca gatgcgcttc gtgaggtttg 1676941 ccgtaaggag ccgatccatg cccggctgct ggaaggaaat cgatatgaca ttggcgataa 1677001 gctgggctgt tttaaagcga gcaccgaaat cggcttaatg cgtcccgaaa tgagatctca 1677061 gcttttggcc tatttagaag atgtgatcaa acgggaaacg aaagaaatgc tgcggtaaaa 1677121 aaattgtaac catcttgctc gtcaatcagt catataatag tgaaaaagat taggacaggt 1677181 tgtgaagaat gtgggcagtt tgataagcga aattttaaca tggctgacga acatgggata 1677241 tgcgggtatt gcgattgggt taatgattga aatcattccg agtgagattg tattagctta 1677301 tggcggctat atggtatcgg agggcacgat tggatttatt ggcgcaatta ttgcgggtgt 1677361 tatcgggggc accattgccc agatctttat ttactggatc ggtcgctatg gcggcaggcc 1677421 atttctggac aaatacggga agtatttatt gattaaaaag catcatatcg atatgtcgga 1677481 aaactggttt cagaaatacg gcgccggagt tgtcttctcg gctcgtttta taccggttgt 1677541 cagacatgcc atatccattc cggcaggtat tgccagaatg ccttttctca aatttgtggt 1677601 actgactgtg cttgctatca ttccatggtc tatcctgttt gtttatttag gcatacagct 1677661 aggaagccag tgggatgatg ttgagaatat agcaggcact tatacaacac cgattatgat 1677721 attggctgtt gtcgtgatag ccctttattt tgtgattaag aaacgtacag ccatatttaa 1677781 acgatagcta gcggatatgc ataggggtga ctgacgctcc cctatgcata tttttttact 1677841 tgcgatgttg atttgccagc ttcagattct ccgctaaaaa tgcgacaaac acttcatccc 1677901 gcacgagcga tgcggcataa tttctcttaa taaaccattc tgcctcttca aacgctgcga 1677961 atgtttcgtc ttgggtttct ccgttaattt gaatattcca ttcgttgtct aaagggaaaa 1678021 gaaaaaatct catttgtgcg cgattttcat ataatgatcc attcgcagat ccctttagat 1678081 tatagatgtt acggaaggca tccggccgta caggatcaat acggaaagct tcagctacaa 1678141 acaactcgta tacttcatcg gttattgaac agccggacgc ttttgcatgc cctccgccgc 1678201 catatcggcc ggcgatttct gacacatcga tgtaatcatg aatggtgcgg agactgactc 1678261 gttttgaccc catgctcaaa atcgcaatgt aatcgaggtg cgggttatct ttccctagcc 1678321 tgttccccag ctctgaatgg tacgattcag cgtgaacgat gcctacacag tgttcgtgaa 1678381 caaaggtttg taccatttcc cttttctttc tgcggaggta gcgctcgatt ttttcgtctt 1678441 ctaaatcaag cagtttttct tcaaaatcat cgaagaaaaa ttcgtcatgc gtggaaaggc 1678501 gctggatcat ttttgcttca aattcatcga ttgacagcaa aaagaaaaga tcattaagcc 1678561 gcttcgcctg tttttgatcg taccgctccc actcccatgt atcgtattgg cggacgagct 1678621 ctgtgaattg atctaaggcg tttgtcggtt tcatgaagcc attttcaatg agatagccat 1678681 ataaaagcga tgtcgcggat gtgagccttc catcatcgta ttccacctgg acaaatcccc 1678741 attcatgctc attcaaatga agggctgttt tatgatggtc aatgagcttc actttgcccc 1678801 ctgcatgaac atactcattc aatctctctt cgttttcttc attgacggcg agatcggtga 1678861 tgaataacgc gtcctgtctg ttgctctcct tcgctttttc taaaaagtac tgcacctgtg 1678921 cgtttaagcc gttgacagag ttataccgga tctctacgtc ttttccgaac gccaattttg 1678981 ctacgattcc gcatcctact ccgtccaagt cgttatgtga atataaatga tacataatgt 1679041 aggccccttt ttatgataaa ctgacaattg ccgctagagg tgcggcagcc tttatttact 1679101 attctaaaaa accaagcgtt ttatgcaatg gtaattagtt gacataatgt tgttattgta 1679161 aatatataaa ggagcgcttt ttttgcgctc ctaagttctt gcttttacac cggataaacc 1679221 ggatgctttc gattggtaaa tgtcatttcc tttgtcatgt atgccttgag ccgtttggcc 1679281 agctcatcac gcagcgaatt ggctgggata acagcatcaa tgatcatttc tgaagccaga 1679341 cggtagatat tgatgtcctc tttgtattcc tcccgtttgc tgctgataaa tgcggctctc 1679401 tcttcttctg gcagctcggc gattttttta gcgtagacag cgtttacagc ggcctcaggg 1679461 cccatgacgg cgatttgggc ggttgggagc gctagacagc aatccggttc aaatgccggc 1679521 cctgccattg catacaaccc cgccccgtaa gcttttcgga caatgacaga gagttttgga 1679581 acagttgcct ccgacatcgc agaaatcatt ttcgctccgt gtctgataat cccagcctgt 1679641 tctacttttg tgccaatcat aaaaccgggg atatcggcta agaacagcaa tgggatatga 1679701 aaagcgtcac ataaggtaat aaacttagcc gctttgtctg ctgaatcgtg gaataagacg 1679761 cctcctttta ccttcggctg gtttgcaaca atgccgacag gctgtccgtg gattcgtgcg 1679821 aggcccgtca ataattccgg tgcaaataag gctttgatct caaaaaatga gtcttcatct 1679881 atgacccgct caatgagctc atgcatatca aaaggtgcgt tttgattttg cggaatgacg 1679941 tcggcaagcg gagtttcgaa gtgttttggc gggcgtttct catgaatggg cgctttttct 1680001 tgaaaatttg ccggaaagta agacaaataa gcccgcacca gctgtatggc ttcttcttca 1680061 gtttctgcaa gaatatctcc gcagccggag attgagcaat gcatacgggc gccacccatt 1680121 tcttcgagag acactttttc tccaataacc atttccgcca tccttggcga acctaaatac 1680181 atggaggcgt taccgtctac cataacgacg atatcacaga aggccggaat ataagcgcct 1680241 cctgccgcag atggtccgaa aagcagacag atttgcggaa tgcgtcccga taatttgact 1680301 tgattgtaaa aaattcttcc tgcaccgcgt ctccctggaa agacattgat ttggtcggta 1680361 attcgggcgc ctgccgaatc gactaaataa atgagcggac agtttaattt ttcggcgatt 1680421 tcttgaattc tgatgatttt ttcaactgtt tttgctcccc atgaccccgc tttcactgtt 1680481 gaatcattcg ccatgacgca aacggtttgg ccgccgattt tgccgatagc ggttacaact 1680541 ccgtcagcgg gaagcccgtc tgacatacat tccgcaaaaa aagcgtcttc tagctcaatg 1680601 tcatcgtcaa agagaaggga aagccgctct ctgacaaaga gcttgccttt ttcccgattg 1680661 ctttgatgat acttttccgc tccgcctttt cgaatccgtt cagcccgttc tgttcgttcc 1680721 ttttcataat ccatcagcat tgcctccctt ttatattccc ttgtatacgg cccgtctttt 1680781 ttcttgaaag gcctgaagcc cttctctcct gtcttttgtc gggatggttt gttcatacgc 1680841 tttttgttca atcgcaaggc ctgtagcaag atctgtctcc aatcctttat tgattgcaaa 1680901 tttagcctga cggacagcga tcggtccgtt ggcagaaatg gctgcggcca gttcctctgc 1680961 ttttggcata aggtcacaag gagccgtgac atgctctaca aggccgattt cttttgcttc 1681021 gtgtgcggtc acgcgtctgc ctgtataaat gaattctttt gcttttcctc tgccaatcag 1681081 ccggggcagc ctttgggtcc ctccagcgcc cgggataata gctaaccctg tttccggaag 1681141 tcccagcaca gctgcttcag ttgcgattcg aaggtcgcat gccaatgcca attctagtcc 1681201 gccgcctaat gcgcttccat ttatcgcagc tatgaccggc tgcggcaagg catcaagtaa 1681261 agccgccgtt ctttgaatga gagatacact ttccagaacc tgatcttctt tcagttttat 1681321 ccgttccttc aggtctgccc ctgcacaaaa cgctttttca ccggtgcctg tgaggatgac 1681381 gcaacggatg tttgagttaa attcaatttc ctggataatc atttgcaggt ttctaagcat 1681441 ttccgctgaa agagcatttg ctgcctgagg cctgtttaag gtgatcaacg ccatatgttc 1681501 atttttaaca gtaaaaagaa tagaatctcc cattgtatgc gtcctccctt ttatcaagat 1681561 gatttaaaca cctgtaaatt tctgctcggc agcggtttgc ccattttttc ttcaatccat 1681621 ttggccgcag atagcagttt ttctagcttt acatttgttt tgatatccat ctgttcaagc 1681681 atgtacacga tatcctcagt tgcggcgttt cctgatgaac ctggcgcata tgggcatccc 1681741 ccaagcccgc ctgccgagcc gtcgaacacc gtgatgccca tttggagtgc tgtgaccatg 1681801 ttggccagag cggttcctct cgtatcatga aaatgcaggg caatttgatt agccgggaat 1681861 cgtgccaaaa gagcttcaag tacagtttcc acttgggcgg gattagctgc tccaatcgta 1681921 tctccaagcg acagttcaga aatcccaaat tcaaatagag cttctgaaag gcgaatgact 1681981 tgttcaatgg ggacatcttt ttcgtacgga cagccgaaaa cagtcgagag gtaggctctt 1682041 gttgtgaggt ttgctttttg tgcgtcgttg tttacttgtt tgagtatatg gagggattca 1682101 gaagtggatt tattgatgtt ttttctgttg tgcgtctcgc tggcggacat aaaaacgcaa 1682161 gcctcgttaa tgcctccttc aagtgcattc tccagtcctc tttgattcgg gacaagtgcc 1682221 gcgtacgtta cccctttttc tcggtcgatg ccttttgcta catcgatagc atctcgaagc 1682281 gccggaatcc atttcgggtg aacgaaggat gtgatttcaa tatacgacag ccctgtccgg 1682341 gaaagctggt tgatccaggt tattttatcc tctgttgcga tccaaacggg ctcgttttgt 1682401 aagccatcac gcgggccgac ttctttgatt gtcacttttt taggatatgg catggtcttc 1682461 ctccaaatta ttgagtggaa ttgctcagtt cgagcagtac gtctccttca tttacaaagt 1682521 cgccttcctt ttttttgact tcttttacga ttccgcttct atctgcaacg atcgggattt 1682581 ccattttcat cgattccaaa atggctacct cctggccctt ttcgatttgg tcgccggctt 1682641 tgacgtggac tttccacagg tttcctgcca tttgtatgct aaccgtcatg acaactgcct 1682701 cctttatagg tgctgtttca aaaagtcagt cgtgacatcc ccttctttaa atgcctttgt 1682761 tgccgcagcc tgtatgagga gcggaaggtt tgttttgatt ccctctacac gatagtcgcg 1682821 aagcgctgtc tctagttttt caattgcttc tgttctggtt tggcctttga caatcatctt 1682881 agcgatcatc gggtcataaa aaggggtaac ggtgctgtct tttgctaccg cacattcgtg 1682941 tctgactcct ttttggtcag gaagtgaaaa cgcagtgatc gtacctggtg acgggaagaa 1683001 ggtcttggga tcttccgcgt atattcgaac ctctatcgca tgcccgttcc gttggatgtc 1683061 tttttgggag aatgtgagtg tatggcccgc agcaatccgc agctgctgct caactaagtc 1683121 caggcctgtt atttcttcag tcacggggtg ttcaacttgc agtctcgtat tcatttcgag 1683181 gaaataaaaa ttttgtttct ggtcaactat aaattcgatg gtgcctgcgt tcgtatagcc 1683241 gattgccttc gctgctttta ccgctgtttg accgatcttc attcttagtt catcgtctac 1683301 aaatggagac ggtgcttctt caatgacttt ttggtggcgc ctctgaacag agcaatcacg 1683361 ttcaaacaga tgtactgtat ggccgtgttg atcggccaaa agctgaacct cgatgtggcg 1683421 cgcatgttca ataacttttt ctatatacat agacccgtca ccgaaaaaat ctgctgcgcg 1683481 ctttttgttt ccctcgtacg ctttttttaa tgcttcttca ttttcaacac gctgcattcc 1683541 gatgccgcct ccgcccgctg aagctttcag catgacagga tagccgattt gacttgcggt 1683601 gcggcaggct gcctctatat ctccgaggga ttcagaaacg cccggcacca cagggacacc 1683661 tgcagcctcc attgcttttc gcgcttcaat tttgctgccc atctttgcga tgatatcagg 1683721 ggaaggtccg ataaacacga tgttttcttg cttgcagcgt tcagcgaacc ggctgttttc 1683781 tgataacaat ccatatcccg ggtggatcgc gtcggctttt gcttttttcg ccgtctttat 1683841 gattctctct atatttaaat aactttcact gactctcgat tccccgatca aatatgcctc 1683901 tgtagcggct tttgtatggg gcgcgtcctt gtctgcttct gaataaacag cgaccgtttt 1683961 aatgccgaga cggctgcatg ttcggataat tctcattgca atttcaccgc ggttggcgat 1684021 cagtactttt gtaaacatga tttcacctca ttgacttgat gataagttga acatttcaat 1684081 cgttttttct cgcagtttat atttttgaat tttgcctgag gccgtcatcg gatagtcatc 1684141 cgtaaaaata acataacgcg gaattttgtg gcgggcgatt ttccctttgc aataggcttt 1684201 aagctcatca ggtgaaacgc ttttaccgtc tttcagttta atccaggctg cagcttcctc 1684261 cccgaatttg gcgtcaggca caccaaccac ctgtacatct aaaacagcgg gatgctggta 1684321 taaaaattct tcaatttccc gcggataaat gttctcgccg cctctgatga gcatatcttt 1684381 taatcttccg gtgatgcggc agtacccgtc ttcatccatg acagcaagat ctccggtaaa 1684441 cagccatccg tcatgattga ttgcttttct ggtcgcatct ttgtctttat aatagccttt 1684501 catgacgtga tagccacggg tgcacagttc tccctgcatg cctctttgaa cttcttgaca 1684561 tgtcccgggt tctacaattt tcacctcagt atgtggcagg gcacggccgg ttgtttcgac 1684621 tcttcttatg aaggaatcat ttgctctcgt ttgtgtaatg actggcgagg cttcggtttg 1684681 tccataggcg atcgtaatgt ctttcatgcc catcctttca atcacagctt tcatcacttc 1684741 acttggacag ggagagccgg ccatgattcc tgttcggagc gtcgatagat catatgcatc 1684801 aaaatccgga tgatgcagct cggcgataaa catggtaggc acaccatgga gcactgtgca 1684861 tttctctttt tctaccgttt taaggacggt aacgggatca aattcttgca cgggtatcat 1684921 ggctgccccg acggatacac atgccaaaac cccaaggacg catccaaagc agtgaaaaaa 1684981 cggaacaggg atgcacatgc ggtcttgaga ggttaaagcc atacattcag cgatattagc 1685041 agcgttattg atgacattga aatgggtcag catcacgcct tttggaaacc ctgtcgttcc 1685101 tgatgtgtat tgcatattaa tcacattgtc tttatccagg ctgttcattc tctcttcaag 1685161 ctcagcatct gtcactgttt tcgccaatat ctctgtatcg tcccaatgat acatgccaga 1685221 caatcgttta ttgccaatat agatcagcgt ttttaaaaag ggatagcgtt cagatttcag 1685281 ttggccgggc tttgcttctt gcagttctgg aattaaactg ttcacgatgt ctggataaga 1685341 agtgcccctg tatgaatcca tgataataag cgccgcggca tccgattgct ttaacaagta 1685401 atcaagctca tgtgcttgat aattggtatt gacggtcacg agcacggctc cgatcttcgc 1685461 agttgcgaac tggacggcaa gccattcaga gatattagaa gcccatatgg cgacgtggtc 1685521 tccttttcca atccccatcc gcatgagacc tttagcggtt tgacggcaca gactgtcaaa 1685581 ttgagcgtac gtatagcgga tatttcggtc tggatacaca acagcatctc gatcgggata 1685641 cgcatcagct gtttgttcca gcagcctgcc gattgtggaa tggatgagtt cagccattca 1685701 ttgttcctcc tttcttaatg ataggaaagc gtttacattt ttattttaaa agctgtctgg 1685761 cgatcacgag acgctgaatt tcagatgtgc cttcaccgat ttccattaat tttgcgtccc 1685821 gcagcatccg ttccacccca tactctttca tatagcctga acctccatgg atttgaatgg 1685881 cttgattgca agctcttgtc gccatttcag atgcgaatag cttggcgtac gccgcttctt 1685941 tggtgaacgg gcggttatga tctttcagcc aggcggcttt taacaccatt tgccgtgcca 1686001 gatcaatttc catcgccatg tcagcaagct taaattgaat cgcttgaaag gaagaaatcg 1686061 gctgtccaaa ctgctttcgc tctttcgcat atgccaatga tgcgtcaagg gccgcttggg 1686121 caatgccgac tgcaagagca gcgatggaga ttcgaccacc atccagcgta tatagaaact 1686181 gtttaaaccc ttttgttgga tcgccaagta agttggccgc aggcactctt acatcttcaa 1686241 gcaagatttc cgctgtattc gaaccgcgga cgcccatttt atcgtacggg ctcgtaatcg 1686301 taagtcctgg tgtgtcagtt ggcacgatta atgcggagat gatgtttttt ccgtctttgt 1686361 ttttgcctgt tacggcggtt acaataactg tgcgtgcgta gcttgcatta gtgatccagc 1686421 acttttcgcc gttgattaca tactcgtcac catttgaaat cgcttttgtt tgagtgcctc 1686481 ctgcatctga gccggcattt ggctccgtca ggccgaatga tccgagtgct gtgcctgaag 1686541 ccagcggcgt caaatgcgtc tgtttttgct cttctgttcc gaagtagtaa agagggcttg 1686601 cgcctagcga gaccgctgca gcatagctta atccagtact gccgcaggct ttgccgactt 1686661 cttcaaccgc taaggcatat gaaatcgtat caccgccaga tccgccgtat tcttctggaa 1686721 atggaatacc catcagaccg agttcaccca tttttttaaa tgtttgcatc gggaactcgc 1686781 ctgtttgatc tacatgttca gcgtgaggag caatttcttt tttcgcaaaa tcttttacca 1686841 tttcacgcac catttgttgt tcttttgtca gctcaaaatt cacatcgttt cctccttcac 1686901 atctttgtaa catcctatta ggcgagttct ataatcattc cctgacaaga aaagtctgaa 1686961 aattaaaact gaatcatttt ttatgtgata atatcagcgg gatgagcaaa tacatgcagt 1687021 aggcgcatac catccatatc gtaaacgcaa taacttggcc ctttgataaa gccgggaaga 1687081 tgaggggaag attccaaagg gaaatcgtat ccatcaataa accgaccgct gatccccata 1687141 tacctagctt gatcaccgcg aactgtgatt gatcgagttt ttgatagaga aagaacacaa 1687201 ggcataaaac aagagcagtg cccgctccca agagaagaaa gttcggcaaa aaggcttctt 1687261 cagccggatc agtcaacaca gcatctccga acagcacaaa aaataatgtg gcacctaacc 1687321 agactagaaa tgaaaacgta aaacacgtcc tgtacgtgtt tctcttcgat tttattttta 1687381 tttagtacta gtttctcaga ttccaataat ggtaaatgtc caaacaccgc ctccatattc 1687441 atgtgaatct cacctttgtt ttttaaaaaa ttcagcggtt taccatcgtt tcctgtccca 1687501 aaatcacttt ttaaaaaaag acgacttaga aagccgtcct tctcatttct tattttgttg 1687561 ttcgtttgga agctttgctt tcgttatgaa gccggtctgc tgaagtgaca taatacgtat 1687621 atttcttgtt gggatctgcc gtgttatcta agaaggtttg ctgctcatgt gtttttcttt 1687681 gcgttgccag caatgttctc tgctttttcc cttcggctct gtatatcgca taataggctg 1687741 tttctttcgt tttttgattt gatgggtgat ctttaatctg cagaagattg ccgtttttgt 1687801 cttcggtgac tttcgtaagc ttcggttttt ttggggcggt attgtcaagc caaggcattt 1687861 gcggaaccag tgccggcttg ctgtaaagat cggtgctgag actgtctttg atgccaagcg 1687921 gatttttgtt gaggtccttg aggctgaaat gcatgcttcc tttcaccagt tcaagctggc 1687981 ggttcaaagt gatttgccgc acatattcct caggatcgga ccaaggcgga tcaaaattgt 1688041 tattgatttt atatgctgcc tggccaatat ataagtgaac aggcctattt ttgacttcat 1688101 tgctccacca atcagccagc acgtcgtaag ccgctgcgtt aaagccgata ctccaataaa 1688161 tttgcggagc aatataatcg atgtcgcctt cttggatcca atgccttgtg tctgcatata 1688221 gatcgtcata atttctgacg cctgcttttg tattcgatcc ggtcgggtca tctgcggcgt 1688281 ttctccatac tccaaaggga ctgatgccga atttgacata cggttttgca gctttaattg 1688341 tttggttgat ttgtttgaca agctggttca cattgtcccg ccgccagtca tcgatattag 1688401 aaaaagcgtc ttttccgtat tgttcgtact gtgcttgatc aggaaattcc tgtcccgcta 1688461 ttttataagg gtaaaaataa tcatccatat gaacagcatc gatatcataa tgttttacga 1688521 cttcttcaat gcctttgacg ataaaatctc tcgcttctgg aatgcctgga tgataataca 1688581 gctggtttcc ataggcggca acccaatctg gatgttttct tgccgggtga tcctcagaca 1688641 atttattaag atctgtatga ttcattgtaa tacggtaagg attaaaccac gcgtgaaatt 1688701 ccaaatttcg tttatgggtt tcttcaatca taaatgcaag aggatcatag ccggggtcct 1688761 tcccttggac accggttaag tattccgacc aaggcccgta agctgacgga taaaaggcat 1688821 cagccgtcgg tttaatctga acgataacgg cattcattcc cattttttgc acatcgtcca 1688881 gcagtttgat atactcctgt ttttgctctt tcacagataa cccttttttg gacggccaat 1688941 caatatttaa tacggaagca atccatacgg ctctcagctc cctgtcagac tgcgcattgg 1689001 ccataaacgg aacggaaatg acaaacgttc cgatgatcaa gctgacaagg aaacggacaa 1689061 tcgacttttg gcaaaccttc attctgtttc ttctccccca ttacatcact ttcactattc 1689121 gctattacgg tattcccggg ctataaaagg gtgattaaca gaatgtctat ctcactaaat 1689181 aaacgaaaaa agtcctaaag catgttgtga accgctttta ggacttttta tcattcatca 1689241 tggtttgcag actttttaac acatcaataa gttttacgcc gacaccgaca gccgtttcaa 1689301 ggatcgcttg tgctccggca atggctaaaa taaagatcag cggtattgca atacgaggca 1689361 aaaaaagata gccaagtccg atcaagatgg cacaccaaac accggcacac cagtagcaat 1689421 tgagcatgta tccaaagtta gaagccggca cgcttttttc atctacatgc ccgttttgat 1689481 caacaatcct tttctttttc ataaaaggtt ttcggataaa ttctgtgatt ttgtcaaata 1689541 caatcaaatg tgtcagcctg taactggcta gaatcagcat gataaaagtt agaaaagaaa 1689601 gacggtccat tgagaagcct ccaagaaaaa ggatgatgtt atcattccca agtgtccctt 1689661 atccattctt gatacaaaaa gaaagacgga cagagaatgg cctctgtccg ctaatccgag 1689721 ctcattccct ccagttctca taataagagg ataagaaaat gtagaaaaaa gcagaaaaat 1689781 gacaataaaa gaaattatat gactatataa tccatatatg cactatatta acggatattt 1689841 tttaaagtac aataaaaaac attaaatttt tataacattt tttttgaata tagtattatt 1689901 tctttatttt tcgtttcttt ttttatcaaa tttccggata taaagtgata aaagtattgt 1689961 tttacataag gtcttataca ctacttttta atcggactaa ttttcttttg tgcatcattc 1690021 ttctaattgt tggaaggttc gacaaagcgt tattacagac ataaaaaaac ctgttttctc 1690081 ttggaaaaca ggtctcccgc tattattgat ttgccaaaat gacagcgatt tgatcctcaa 1690141 tatcttttcc atcctcttca tcaatcaatc catttagaag aatagagaaa acaagttttt 1690201 ttccgctctt tgtttctgcg taccccgata gagagcttac cgtactgagc gatccggttt 1690261 ttgctcttac ttttccttgt gcaggagtgc ctttcatgcg gtttctcagc gttccgccca 1690321 ccattctgtc aggattcccc gcaacaggta aagaatttag ataagccgag aaccaactct 1690381 gatcctgaat gtcatataac agctgtgaaa gttgatctga ggatacagca tcaatatgtg 1690441 agattcctga tccgtccctt aagacgagtg atttagaatc aacaccaaat tccggaagcg 1690501 tactgtttaa cacttcgagc cccttttccc agctcccttc tccttttttc actttcccca 1690561 tctcttttac gagcacttcg gcatgtccgt tattacttaa tttcatgaac ggcacaaaaa 1690621 gtttcgataa aggcattgag cgatgagaga gcagcacatc tgaagaacta ggtgcttcac 1690681 ccgtcttgat gtcccctttc acagtaatac cttgtttttt tagtgactgc ttaaataaat 1690741 ctaaggcata tccggcaggc tcccagacag aaatccattc ctttgtcttg tttgcgtcaa 1690801 ccggtacgct cccttcaatt gtaatcgtgt ttgttccatg ctctctttcg attgtgaggt 1690861 ctttctctga accggcagca gtcgttttag catcgttctt tatcgttata taatcggttt 1690921 tcggagagac agacacggca ggctcttccc cttctttttg atttggggtg acctcaacaa 1690981 tcacagtgcc tgcatcatag tcttcgtttg gagacgctgt tagagcggag attggcgcgc 1691041 cataatatgt gtattcatcg ctccaaggca tatcaggtga taatcgcatg tcatcatgcc 1691101 acgtatcatc accgatcaga ttgcctttaa ttacttttac gccggaatgt ttcaatatct 1691161 cagccatttt gtcaaaatca gatggtaaaa gtgtcggatc gcctttccct ttcaaataaa 1691221 ggttaccatt cagctttttc cctttcagtg ttccatccgt ccggacctcg gttgtaaaag 1691281 aatagttctc gccaaggaca gaaagtgccg cggccgctgt caaaagcttt agagaagagg 1691341 caggcctcat tcgggtgtct cctgaatgtt catatagaac agcacctgtt tccgcagagc 1691401 gaacggtgat gccggccatt gcgccttcga gggcaggatg atcagctaaa atcttatcga 1691461 tctgcccgga aagtgcatct tgtttttcag cggcaagcgc agcctgatgc atataaggca 1691521 ccgaagcaac gacgaaaagc agtaaaacag caacataaag ctttatgctt tttttcatta 1691581 atttccccgc ctctctgcgc ttcatcattg gctattgatg attcagttca atggtgatac 1691641 tgcttttagc tgtcgtttct tctcccggct ccagcacttg taaaccagtg agtgacgaag 1691701 gtaaatcaag attcactgcg tttgtcaccc atgtgtaagg ctcagggcat aaataccctt 1691761 gttttccgtc cgcattgtat acaacccaat gtttaaactg ttcatctgcc ttataaataa 1691821 tgctgatatg tgcatgctga tgataaatga ctgcctggtt ttctccgccc ctcttctgat 1691881 aagaagataa aaagacatca tccagctgct tgtggcgcaa atccattcct tcatgcaaag 1691941 cttctttata cgggacatcc atcagcttcc cggtcggcag caggcgttca tccaactccc 1692001 attgctgatc tgctgtcagg gagaataacg agctttctgc cggaaatata aatgtagtat 1692061 gataaccaat tccccaagga aacgcttcct ttcctttgtt catgaccgtc gcatgtttaa 1692121 atagggtatt ctccttgatc gtgtatgtca tccgaacgac ggcatgatga ggaaattgct 1692181 tctgcacatg gggaagctca gaaagatcaa tttctgtttc aacaatcact ccttcatcag 1692241 tttgcttcgt ggtcacgaca ttccactttt catggtaaag aaacccgtga agatggttgt 1692301 gtttatcctt ctcgttgata tcaaaatgat acgttctgcc ccggaaactg aatgtaccgt 1692361 cacttatgcg gttaggcggg aacaggattg gaatgccata caatgttggt gtgtcgtgaa 1692421 aactttctgc tgtttccggt tcacgcaaaa gctggacatt tgttgttttg tccacgagag 1692481 aaatgacgtt gctcccccac tcagggacaa caatcatttc tagatgttcg ttgcccgctt 1692541 tgatggccgg cgttcccaaa tacgtgattt tctcaataaa gtttgccatg tttactcaac 1692601 ctctccttga ttcattgcta gtataagaat tcaatgtact gtaccatatt tcctccattt 1692661 tatattttcc cctatcaaat aaaaaaacac cgttcaaact tatgaacggt gtgattcgga 1692721 ggctattgga tgagacgtgt gatttgtttc tttttccaga cgaattgata atacccataa 1692781 atcaacagca agctgacggc aaacgcagct ggataaccaa cccagacgcc gagtatttca 1692841 agctttgtat agtgagaaag gacgaaagcg acaggcacct ctactcccca gattgcaaaa 1692901 atactgatga cggtcggcca taaaactgtt ccgcttgccc gcatcgttgc agaaataatt 1692961 tgggcatttc caaacagcaa atagctccac agtgtaatca tcaaaagacg gtgcgcaatg 1693021 taaagcgtct cttgctcggt taaaaataac gataaaatct gatgtgaaaa aacatagatc 1693081 agaatgatca gtacgccgcc aatgatataa ttcagccaaa tcccaacgcg aatgacctgc 1693141 tttaagcggt caaactcgtt tgctccgatc gattgcgcag cgaaaataga aaccgcaata 1693201 ccaaggctga cggccggcat ctgtacatag ctggccacct ggttgaccac tccgtatgca 1693261 gctgttgcat tagagccgta atgattgacg aatgaaataa ccgctatctc tgataatgag 1693321 acaagaatca tattgatgct tgctgggacc ccaagacgca gcaggagaac cagcagttcc 1693381 ttatccattt tcaaataacg acgcactgtt ttatcaaatt gcagcgggtg ttttcgcttt 1693441 cgtaaataca ccattaacac gagaaaagtc gcaatcgtgg aaatgacagt tgcatatgcc 1693501 gagccgtata tgcccagttt cggaaaacca aacatgccaa ggattaaaac aggcaaaagc 1693561 gcgatgttga tgaccgtgct cacaatcagc gtataaaacg gtgtcttgga atctcctgtt 1693621 ccgcgcaaaa aggtagtata tgcaaaatat aaaaacataa acggcatagc ataaaataaa 1693681 atacgtgcat agttagcgct gacatgaatg acattttcag gtgttcccat taaacgaagg 1693741 atatccaggg tgaaaatact gccgataacg gctaacacaa cgcctaataa aaatgtaaac 1693801 gtgagtgtcg tcccgacaac agcctttagc cgttcctcat ttttcgctcc gtaagcttgt 1693861 cctatcagaa tcgaacttcc tgaaccgatc ccaatcgtaa atgagattaa aagaaaaaat 1693921 aacgggaaaa aggatgatac agctgccact gcatcaacac cgagccatct gcctacagcc 1693981 atcatcccga ctagctggcc gactgattgc agcacattgc tcagcagaag cggcactaaa 1694041 aagagtgaca tcgaccgcca aactgatggt ttgcttttct tttgagttac aagaggttct 1694101 tgtgatgttt ccatattaaa ggactccttt atttgaaatc gtttttaaac atgccctcat 1694161 tttttgacaa aaacaggata tgtaacatgt tattattcat cactgcactt atgaaaccct 1694221 tcccgattct tctaatttta cacatctttt tagcttatga agaataaact agcaagtaat 1694281 ggcgtatttt ttgtgagtaa aagaataaaa aataatttat gcaaaagtat tgtaatctat 1694341 ccgtaattat tgtaacattt gtaacataag agaaagagat tttgaaggag agagcgataa 1694401 tgaaaaaatg tcttctattt ctaacaacca ttgcacttat tctgtcatta agcacaaatg 1694461 catttgcgaa aaatacatca ggcgatttat cacaaaaaca agcattacag ttggcattat 1694521 ccgctagaga acatttttgg aacaccatga gcggccacaa tccgaaggtg aaaaaagcag 1694581 tttgcccatc aggcacattc gagtatcaaa atcttcaata tgtatacatg tgcagtgatc 1694641 taggcactaa agcaaaagcg gtgaattatt taactcctat ttttacaaaa acagcaatcg 1694701 aaaaaggctt taaagattat catttcactg tttcaaaagg aaaacttgct gttccaatcg 1694761 gtgacggaga caatcttttg aattggaaaa aatcaactgc taaactgatc tctaaaaaag 1694821 gcagcacaat cacatacgaa tttactgtcc ctacattaga cggatcccct tctgcaaaac 1694881 ggaaagtgac atttgtgaaa gaaaataaaa aatggaaagt caatcaattt gacgcagtta 1694941 tataagaaaa acgcccggta taagcgggcg ttttttattt ggtttgcata aagaaagaca 1695001 acaggcgaaa agtgcctgtt gtctttttgt gaatataacg ctctaggaga gattcgaact 1695061 cccgacctgc agtttaggaa actgctgcac tatccgctgt gctactagag cttttggtat 1695121 ttatatagta gctctgatga tcaatatttt caagcgattt gtattaaagc cctccaaaaa 1695181 ccttatatgc ggctcttgtc gtatcttcat caataccgat ataccgcatt gtaattgatg 1695241 gtgatgaatg attcagtatt ctctgcagct cggcgatgtc tttcgttcgc tgataaaaat 1695301 gatagccaaa cgttttccgg agtgtatgcg tccctatctc ctcaagtccg cacgctgcag 1695361 cggcctctct taaaattctg taggcctgaa tgcgggaaat cggcttcctg gtccgcactg 1695421 atttaaaaag atattcgttt tccttcatgt ctttcgtata ctcgtatatt tcctgtttca 1695481 gcgattctaa aataagaatc tttcttttct ttttcgtttt gctttcagtc gcccataaat 1695541 gatctttatt ttgaacgtcc ttcacttgca gcggcagaat atcagaaata cggagcgcgc 1695601 tgttgatgcc gaaaataaac agaaaataat cccgcttgtt tttgttaagc aaatactgtt 1695661 tgacttcttg gattttctct agactgcgaa tcggctgtac aatatgcatc aaaaaactcc 1695721 ttaaaaaccg ttatgtaaca ttttgaggtc tatgttacta ttatagctga aaaacgttga 1695781 atgtcaaagt gcggcggcgt ttatgtaaca taatatacat agtgttacat aagcttttaa 1695841 aaaagcttct tccaaccttc accctataaa ataagcttta aagcctctta taaagctttt 1695901 aacctcttgg atacttatcc ccctactaat catcaaaaaa cctcttaaaa tgaaatctga 1695961 cactcccaat tttctggagc ttccgcaaaa atatacaaaa aaagacacaa tttcaaattg 1696021 tgtcctaatc ctcatccttt acatcaatat cttccgggat cggttcattt aatatttcct 1696081 gcacaagtgc tttgtaattc tccagctgtt cgagatgcgt tttgaactgt tccttataaa 1696141 tcaaaaattg ctccccgtca tgaacggctc tgattttccc ttcgagcacc aagcttttaa 1696201 tataatcctc tgaaagattt gtatattctg ctgtttcttc aatcgttaaa tacatatagc 1696261 agtcccttct taatccgtat gctgattcta atatagcaca tggctcatat caatataatc 1696321 aattctgcac agaaaaacgg cattatgcac tatataatat accatttgtc acttgtgaaa 1696381 acgctgtaat ttttttacgc taagattgta acaatacagc ttcatatagg agggagaaca 1696441 tgaaaagaac gtggaacgtc tgtttaacag ctctgcttag tgttctgtta gtcgctggaa 1696501 gtgtcccttt tcacgcggaa gctaaaaaac cgcccaaaag ctacgatgag tacaaacaag 1696561 tagatgttgg aaaagacggc atggttgcga ccgcacatcc tcttgcttct gaaatcggtg 1696621 ctgatgtgct gaaaaaagga ggaaatgcta ttgacgcagc ggttgccatt caatttgcac 1696681 tcaatgtaac agagccgatg atgtcaggta ttggcggcgg cggttttatg atggtgtatg 1696741 acggaaaaac gaaggataca acgataatcg acagccgtga gcgtgctcca gcaggcgcaa 1696801 ctcctgatat gtttctggac gaaaacggca aagcaattcc tttctctgaa cgtgtaacaa 1696861 aaggtactgc cgttggtgtt ccaggcactc tgaaagggct ggaagaagcc ttggataaat 1696921 ggggaacccg ttcgatgaag caattaatta ccccttctat taaactcgct gaaaaaggct 1696981 ttccgattga ttcggtgttg gcagaggcca tttctgatta tcaggaaaag ctttcacgga 1697041 ctgccgcaaa agatgtattt ttaccaaatg gcgaaccgct taaagaagga gataccctta 1697101 ttcaaaagga tttggctaaa acatttaagc ttattcgctc caaaggcact gacgcttttt 1697161 ataaaggaaa attcgccaag acgctttctg acactgtcca ggatttcggc ggatcaatga 1697221 cagaaaaaga tttagaaaat tacgacatta caattgatga accgatttgg ggagattatc 1697281 aaggctatca aatcgctact actcctcctc caagctccgg cggtattttc ttattgcaaa 1697341 tgctgaaaat ccttgatcat tttaaccttt cacaatacga tgtccgctca tgggaaaaat 1697401 atcagctgct tgctgaaacg atgcatttgt catatgccga ccgtgcgtct tacgcaggtg 1697461 atcccgaatt tgtaaatgtt cctctcaaag gcctgcttca ccccgattat attaaagaac 1697521 gccagcaatt aatcaaccta gatcaagtga ataaaaaacc gaaagccggt gacccttgga 1697581 aataccaaga aggatcagca aactataaac aagttgaaca gccgaaagac aaagtagaag 1697641 gccaaacaac ccactttaca gttgctgacc gttggggaaa tgttgtttct tatacaacaa 1697701 caatcgaaca gctattcgga acgggtatta tggtccctga ttacggtgtt attttaaaca 1697761 atgaattaac ggattttgat gcgataccag gcggagctaa cgaagtacag ccaaacaaac 1697821 ggcctttaag cagcatgacc ccgacgattt tatttaagga tgacaagcct gtcctcacgg 1697881 ttggatctcc tggcggggcc acaattattt catccgtttt gcaaaccatt ctctaccaca 1697941 ttgaatatgg tatggaatta aaagcagctg ttgaagagcc gagaatttac acaaacagca 1698001 tgagctctta ccgttacgaa gacggagttc ctaaagatgt cctcagcaag ctaaacggca 1698061 tgggccacaa attcggcaca agtccggtgg atatcggaaa cgtgcaaagt atatcgatcg 1698121 accatgaaaa cggcaccttt aaaggtgtag ctgattcaag cagaaacggc gcggcgatcg 1698181 gcattaattt aaaacgtaaa taaataaaaa actgtactcg cttcaaatga gtacagtttt 1698241 ttcatgcaga tctttaaaat aaaaactgac aaacgtcttt attctgctaa tgcacgtcta 1698301 tcttcatctt ttcatttcgt ttatctcatc aagaaatgtc tgaaacgcac tcgtaataaa 1698361 aaagtctttc ctgtatataa agacgatctc taagtcttga tatgatggtg gcagctgatg 1698421 aatccataca tttgtacgat gctcggagcc gtcaacagcg gactttggga gcagcgccgt 1698481 acccatcccg gcggaaacac cttttataat agcctccaat gtgccaaact ctatgatttt 1698541 ttgattgtgt atgcctgctt cctctagtaa tcttttgacc ctgtcacgat gagaacagcc 1698601 agccccaaaa aagagcatcg gctgctgaag catgtcttct gccgtccctt ctcgtgatga 1698661 aatcaaaact aattcatcat gggagacatg gagttgtcta actgcagcgt gttcaaccgg 1698721 cccatataca aaagcgccat caactttatg atcaagaacc tgttgaatca aatgatgcgt 1698781 atcagctgtg ttcactgata aatccacttc aggaaaacgc ctgaggaagg atgctgcatg 1698841 ctcaggcaga tgcgttaccg ccattgtttc cagtgatccg atccgcaaag gcccttttgg 1698901 ttgcctgctc attcgggtcg atttttcagc ttggtctaac agcgataata cttgatctgc 1698961 atattgtaaa agattttctc ctgcagcagt cagcttcatt ccccgattcg ttcgatgaaa 1699021 aagcctgata ttcaaatctt cctcaaggtt atgcactctg gctgtcacat tcgactgaac 1699081 ataattcagc atttgggctg ctttcgttat gcttccttcg cgagcaacag cctgaaaaat 1699141 ctttaaatct ccgctttcca cgcgctctca cctgcttgct atgatgaaaa gtgatattgg 1699201 ctatcatatt tgttcatttt actcgaagaa aaccgctatg taaaatatgt aaagatatga 1699261 aaatacaatt aatgaggagg cagacagcat gaaagctgta attcacaacg gaaaagccgg 1699321 tcttctgggg ttatcagttc aggacgttcc atcaacaaag cctggatacg gagaggtaaa 1699381 ggttaaatta aaatctgcag gcctgaatca tcgtgacttg tttcttatga aaaacaaatc 1699441 tgaacaagat cctcacatga tactgggttc tgacggcgcg ggtatcatcg aagagattgg 1699501 tgaaggcgtg aaaaatgtta ctgttcagac agaagtagtc attttcccga cattgaactg 1699561 ggatttgaca gaaaatgttc cacctgtacc tgagattctg ggaggtcctt cggacggaac 1699621 acttgctgaa tatgtgatca ttccttcaca aaatgcaatc aaaaaacctg cttatttatc 1699681 ttgggaagaa gcgggcgttt tacctttatc cgctttaact gcatatcggg ctctgtttac 1699741 aaaggggcaa ttaaaaaaag gcgagcatct attgataccc ggcatcggca gcggtgtagc 1699801 aacctacgct ttatttatgg ctaaggcgat tggggcaaca gtaagcgtga cctcccgcag 1699861 tgaggagaaa agaaaaaagg cgctgaaatt aggtgctgat tacgcatttg acagctacag 1699921 caattgggat gagcagttgc agggaaaaaa gatagatgtt gttcttgaca gcataggacc 1699981 tgccctcttt tcggaatact tccgccatgt aaaaccaaat ggccgtattg tcagctttgg 1700041 ggcaagctca ggggataatc tcagttttcc ggtgcgttct ttattctttc ctcaggtcaa 1700101 tgttttggga acctcgatgg gaagcggtga ggaatttcaa gctatgctcg ctttcattga 1700161 caaacataag ctgcggcctg taattgaccg gatatatcct ttagaaaaag catgtgaagc 1700221 atataaaaga atgcaggaag gcagacagtt tggaaacatc gggatcgtaa tggaataaaa 1700281 aaagaaaccg gctggcagcc agaccggttt ctcttatatg ataatcccct ttatttacgg 1700341 aagaactgaa ctccccatca aatatcgatc cacttcacgc gccacttcac ggccttcatt 1700401 aatcgcccat acgattaagc tttgccctct tcttgcatcc cctgcggcga atacaccatc 1700461 gatatttgtt tgataatccc catatgctgc actgattttg ttatttactg aattaacacc 1700521 gaactgtttc aacagcggct gttctgtgcc ttcaaagccg atagcgataa agacaagctg 1700581 agcaggccat actttttccg ttccaggcag ctcgcggaac tcgtattttc catgctcatt 1700641 tttcactttt tccatttgga tggtatgaag ctctttcagc tttccgtttt tatccgcgac 1700701 catttttgtc gtttgaatgg agtattctct cggatctctt ccgaattttg cttctgcttc 1700761 ctcgtatgca tattcaagcg taaagacgtg tggctgttca ggccacatat tgtcattcgt 1700821 gcgggctggc ggaagtttcg ggtgtttgcc gaattggtgc acgcttttgg ctttttgacg 1700881 cagagcggta gccacacagt cagctcctgt atctccgcct ccgattacga tgacatcttt 1700941 ccctttggca tcaatgaatt gcttgtcttt aaaattagaa tctaaatagc tttttgttgc 1701001 aagtgtgagg tagtccattg cgtaatggac tccttttgag tcgcgtcctt cgattaagag 1701061 gtcccgctgt ttttgagcgc ctgtgcataa gatcacagca tcaaattgct cctttagctc 1701121 atcagctgta atgtcaacac cgatttctgt gttcgtgaca aaatcaattc cctcttgcgt 1701181 cagcaattta attcggcgtt ctacaatgcc cttctcaagc ttcatgtttg gaatgccgta 1701241 tgttaaaagg ccgcccgctc tgtctgctcg ttcaaaaaca gtgacggaat gtcccgcttg 1701301 attcagctgg tcagcactcg ccagtccggc tgggcctgac ccgacgatgg ccactttttt 1701361 gcctgttcgt ttttttggaa ttctaggttg aatccagccg ttctcaaatc ctttatcgat 1701421 aatggtccgc tcgatgtttt taattgatac ggccggatct gaaatcgcta aagtgcatga 1701481 tccttcacaa ggagcggggc atacccgccc tgtgaattca ggaaagttgt ttgttttcaa 1701541 cagacgttcc aatgcttcct tccatctgcc ccggtagaca agatcattcc attcaggaat 1701601 taagttgtaa atcggacagc cggatgtaaa tccgttaatg tccgcaccga tctggcaaaa 1701661 cggtgtaccg caatccatac accgcgcccc ttgccgtttc gatgcttctt ctgaaaaagg 1701721 agcagaatat tctttccaat cctttaagcg agtgagaggg tcccgctccg caggtttttc 1701781 tcgtttgatc tccataaatc cagttggttt ccccatgttc ctctcccctt ccttactgta 1701841 ctaccgcttg tttttgtccc gatgctgctg tattctgctt tggcttcgtg ttggcctcaa 1701901 aagcgaacat gatggcttct tcatctgata aacctgcagc tttttgctct tcgatgcttg 1701961 cgagcatttg tttatagttt ttcggaatga ctttgacgaa ttttttcaca ctgtcttccc 1702021 attgatctag cagatcttct gctttttggc tgtttgtata cgcagtatgt ctttcaagca 1702081 ttgctttgat ttgctggatt tctttctcat cctctaatga ttcaaataaa atcatctcaa 1702141 ggttgcattt gcgtttaaac gctttgacat cttcggtcag tacataagcg attccgccgg 1702201 acatacctgc cgcaaagttt ttgcctacat caccgagaac gacaacgctg ccgccagtca 1702261 tgtattcaca gccgtggtcg ccgatgcctt ctacaactac gttcacaccg ctgtttcgaa 1702321 cggcaaagcg ttcaccagca cgcccgttaa tatatgcttc tccgcttgtc gcaccgtaaa 1702381 aagccacgtt gccgataatg acattgtcat ccgaagcaga gttgaatcct tctgatgact 1702441 tgacgatgat ttttccgcca gaaagccctt ttccgacgta atcatttgag tctccgtcca 1702501 aataaagcgt catcccttta ggaacgaaag ctccaaagct ttggccggct gatccggtaa 1702561 agtgcagctt gattgtatct tcaggaagac cttcttctcc gtaacgcttt gagatttcac 1702621 tgccggttat cgttccggct acacgatttg tattattgat ttcaatcgaa atatcagctt 1702681 cttttccaga ttcgatggct tcttgtacgg ccgggagaat tgttgtaata tcaagtgatt 1702741 gatcaatttt atgattttgc ggcgattgga acgtccgcac cccttcaggc tgataaagaa 1702801 gggtagacaa atcaagctgg cttgctttcc agtgctcctt tgcccgttca cttgcatgaa 1702861 gtacatcagt gcggccgatc atttcatcaa atgtcttgaa gcctaacgca gccatgtact 1702921 cacgaacttc ttcggcaatg aacagcatat agttcacaat atggtcagga tctcccatga 1702981 actttttgcg aagctctgga ttttgtgtcg ctacaccgac agggcatgta tccaaatggc 1703041 aggcacgcat catgacacag ccgagtacaa ctaacggagc cgttgcgaaa ccaaattctt 1703101 cggcgccgag caaggcagcc atcacaacgt cgcggcccgt catgagcttt ccatctgttt 1703161 ctaatacaac acggtcacga agtccgttca gcattagtgt ttgatgtgct tctgcaaggc 1703221 caagctccca cggaagccct gtatgtttaa tactggtttt cggagaagcg cctgtacctc 1703281 cgtcatagcc gctgatcaca atgacatctg cagtcgcttt ggcaacacct gcagcgattg 1703341 ttcctacacc tgcttttgac accagcttta cgctgattct tgcgtcacgg ttggcatttt 1703401 tcaaatcgtg gatcagctgg gctaaatcct caatcgaata aatgtcatgg tgtggcggag 1703461 gtgagattaa tccgacacct ggcgttgacc cacggacatc ggcaacccat ggatatacct 1703521 tgttgccagg aagctgcccg ccttcacccg gcttagcacc ttgagccatt ttaatctgca 1703581 gctcatcagc attgacgagg taatggcttt tgacaccaaa ccgtccggat gcaatttgtt 1703641 tgatcgcact tcttctatca tcgccgttct catctggaac aaagcgtttg ggatcttctc 1703701 cgccttcacc gctgttgctt tttcctccaa gacggttcat tgcgattgct aaagcttcgt 1703761 gcgcttcctt actcaaggac ccgaatgaca tcgcacccgt tttaaaacgt ttgacaatcg 1703821 attcagcgga ttcaacctcc tccaacttca aaggcttgcg gtttccgtca aatgcgaaca 1703881 agttccgcaa aaatccgatg cgttcttcat cagccgcttt tgtatactgt ttaaacagat 1703941 tgtaatcatt tctgcggcac gcccattgca aagtatgaat cgttttcgga ttaaacgcat 1704001 gatgctctcc gccatttctc cattggaagt cacttcccgg ttcaagcgtt ttgctgtaat 1704061 catcctgata cgcttcccgg tggcggcgct gtgcctcttc tgcaattgtt tgtaaatcga 1704121 tgccgcctag ctgtgatgca gtacctgaga aatagcggtc gatcacatcg cggctgattc 1704181 ctaccgcctc aaagatttgt gcgcctctgt agctttgcac agttgaaatt cccatcttgg 1704241 acatcacttt tacgacgccc tcagtaatgc tttttccata tttgctaacc gcttcttcat 1704301 agctgatatc caaacggcct tcatcaattt cctgcttgta ggtcgcataa gcgagataag 1704361 ggttaatcgc atctgcgcca taaccgatta acgctgcaaa gtgatgcact tcacgtgctt 1704421 ctcccgattc cacaataatg ctgaccttcg tacgcagccc tttgcggatt aagtgctggt 1704481 gcagtgcgct tactgccaga agcggcggaa ttggtgtcag tcgttcgttc atctttttgt 1704541 ctgataaaat taacaaactt acgccttggc tgatggcttt ctctgcctgt gtgaacatgt 1704601 cctttaaacc gcgttcaaga tcctctgaaa acagcacatc aattttttgg ctttttaaat 1704661 caggatgaac aatcgttttc aatgcgtaaa actgttcatt ggataaaaca ggtgtataca 1704721 gtttaatccg gcgaacattt cgttcacttg gatgaagaag atcgccttcc gcaccgagcc 1704781 aagtcatcgt tgaagtgaca agctgctcac gaatcgcgtc gattggcggg ttcgttactt 1704841 gtgcaaacag ctgtttaaag tagttaaaca gcgattgcgc tcggtcagaa agtacagcaa 1704901 gcggagcgtc attccccatt gaaccaaggg gatctttgcc ttctttaata acaggaatta 1704961 gatacttttg gatatcctca tatgtgtatc cgaatgcctt ctggcgagta agaagatcac 1705021 taaattgttc ttcttctctt gactccggat caggatttac ttgtacaagc tcttcttcaa 1705081 gccatttttg gtacggatac tcagttgcaa tttgtgtttt gacttcctca tcggagataa 1705141 tacggccttc ttccaggtcg attaaaagca ttttcccagg ctcaaggcgg tttttatata 1705201 aaacgttctc ctgttcaact tcaataacgc ctacttcaga tgagaaaata atataatcat 1705261 cttttgtgac ataataacgg gccggacgga gaccgttccg gtcaaggatc gccccgattt 1705321 gtttaccgtc agtaaatgaa atagctgtcg gtccgtccca aggctccatc agggagctat 1705381 ggtactcgta gaacgccctt ttttccttgg acatatgcgt attttccgtc caaggctctg 1705441 gaatgagcat cattgccgta tgtgccggtt tgcgtccagc catcacaaaa aactcaaatg 1705501 cgttatccaa aatggaagag tcactgccat cagcattgag aatcggcaaa atcttgttta 1705561 agtcctcacc gaagctttca gaaacaaatt gctgctcacg tgctctcatc cagttgatat 1705621 ttccgcgaag ggtgttaatt tcaccgttgt gaaccaaata gcggttagga tgcgctcttt 1705681 cccatgtagg gaatgtattg gtactgaagc gtgaatgaac aagcgcaaaa gcagaaacga 1705741 atgcttcgtc ttgcagatca gaataaaatg catcaacctg ttcaggtgtt aaaaggcctt 1705801 tgtaaacaat ggtctggctt gaaagactgg caaaataaaa atcaagacct tccgttactc 1705861 cccaattttc agcctgttta cgaatgacat acaattttcg ttcaaaagat aaattgtcct 1705921 ttagatcaga acttgcgccg ataaatacct gacggacaaa cggacagctt ttttgcgcca 1705981 ctgttccgat ttttccgaca tttacaggta cagttctcca tccaagaacg acttggcctt 1706041 cttgttcaat tagtgcattg atttgctttt caattttttt tctttcatct tccttctgtg 1706101 agaaaaagac cattcctacc ccgtaacgtt ctttttctgg cagattgatg tttttgcact 1706161 cttttctaaa gaaagcatca gggatttgaa ccagtaagcc ggctccgtct cctgtatccg 1706221 gatcactgcc ttgccctcct ctatggtcta gctggcaaag catcttaagt ccttgtttga 1706281 caatgtcgtg agtctgcttg ccctttaagt gtgcatatag gccgattccg catgcatcat 1706341 gttcaaattc aggacggtag agaccttgag cttttggcat ttgattgtac gtcataattc 1706401 ctctcccccg atcaatttcc gataataccg gtcataaaat ctaacaactc tataatcatt 1706461 gtaggttttc aaaacgatat aaacaatata taatttagat caaaagaatc tcaaaatgag 1706521 atagatggat gtgagacaaa catggagctg cgccaactgc gttattttat ggaggtggct 1706581 gaaagagaac acgtttcaga agccgctgat catttgcatg tggcccaatc agcaatcagc 1706641 agacaaattg ccaatcttga agaagaatta aatgtgacct tatttgagcg tgaagggaga 1706701 aatatcaaac tcacgccaat cggaaaagaa tttttaattc atgtgaaaac ggcgatgaaa 1706761 gccattgatt atgcgaaaga gcaaattgat gagtatcttg acccgcatcg cggaacggta 1706821 aagatcggct ttcctacaag cctcgccagc cagcttttgc cgactgtcat ttcagcgttt 1706881 aaagaagaat atccgcacgt cgaatttttg ctgcgccaag gctcctataa gtttctgatt 1706941 gaagctgtca gaaaccgcga tattgatctg gccttattag ggccggtgcc gacgaatttc 1707001 tctgacataa cgggaaaaat attatttact gaaaaaattt acgcgcttgt tccattaaat 1707061 catccgcttg ctaaacaaaa aacggttcat ttaatcgatt tgcgcaacga ccaatttgta 1707121 ttgttcccgg aaggatttgt acttagagag atggcaatcg atacttgcaa acaagcaggc 1707181 tttgctcctc tcgtttccac ggagggtgag gatttggatg cgatcaaagg gttagtgtcc 1707241 gcaggaatgg gcgttaccct tctgcctgaa agtacttttg ctgaaacaac acctcgtttt 1707301 actgtgaaaa ttccaattga gttccctcaa gtaaaacgga ctgtcggaat cattaaaccg 1707361 aaaaatagag agcttgcgcc ttccgcgaat gatttttatg agtttgtcat tcaatttttc 1707421 tctaagctgg agcagtatca ataaaaaaaa tgaacccgag cttctatata gaagcttcgg 1707481 gtttttttct gcaaattaat ttacaggtaa agaaaaatcc acatggcaaa caaatgcttc 1707541 ttgatcaatt agagctctat ttgtcagttc ctttttcttt tccggttctt gaagctgtac 1707601 agaagagtaa ttgacgattc caaggccgat ttccgtccct tttgaatcca tcagccgaac 1707661 aactgaaccg cttttgaatt tccctttaat cttctgtaca ccgtctaggt ataaactcga 1707721 ttgtccgttt gttatttttc gtgaacaatc atctgataaa atcatttcac cttccggacc 1707781 ggaattaaaa gcgatccatt gctccttttg attcaacgga agcgttcctt ctgcttcaaa 1707841 ataggtgcct tccgcctgtt catgaacggc gtggtataaa atatcgccag catctgcctg 1707901 acctaggaaa cctttaatgc cagacgccat tacgatttta aacgcatcaa gcttagagcg 1707961 catgccgccg gtgccaacga tgcttccagt gtcacctgcg catgcttcga tgtcaggtgt 1708021 tatttcactc acccgctgta tctttttcgc ttctggattt gtgcgcggat tgccgtcata 1708081 taatccgtct atatctgata aaatcacaag catatctgca tcaatcaatc ctgcgacttt 1708141 tgctgcgagc gtatcattgt cgccaaactt gagccgattg acggtaactg tgtcattttc 1708201 gtttatgatc gggatgatgc cgcgctcgag cagtacattc attgtattcc tgacattgtt 1708261 gtatcgatat tcatcagaaa aatcgcttct cgtaattaaa atttgggatg cgacatagcc 1708321 gtgtgccaaa aacagctttg aataagcctc cattagcaat ccctggccga ttgaagctga 1708381 tgcttgtttt tctggaagct tctcgggcct ttggataaat ccgagcttcc gatatcccgc 1708441 cgccactgcg cctgaggaaa ccaaaatcac ttcataaccg gcgtctttga gtttgacgac 1708501 ctggtcgacc aacgcttcta attttcgaat gctgatttct ccatgaaggc ttgttaatga 1708561 actgcttcca atcttcacaa cgactctttt catgcttgta tcaggcgtca ctttatcact 1708621 cctgatagcg gcgctgcagt tttttcgata tcttcgctga tttcctttga acgcttagcc 1708681 gcatgcttta ttgcttgaga aatcgcttct ccgccgccgc tctttttcaa ggcttgcagc 1708741 cccgctgctg tcgttccgtt cggtgacgtg atattatctc ttaagatctc aggatgttct 1708801 cctgtttcca tgagcatttt tgcggcacct aaaagtgtct gtgcgccgat gcttcgagat 1708861 aactgtttat cgaggcccgc ttcctcgcct gtcttttcaa tgaattccat taaataataa 1708921 aaatacgcgg gtccgctgcc tgcaattccg gtgaatatat ccatttgatt ttcttggatt 1708981 gtatagactt cgcccatgca tccgagcaat gcttcggcca gcttcttcag gtcttccgac 1709041 acatatttgc caagggcaat agctgttgca gaagcgccaa tcatactgga agtgttgggc 1709101 atcactctga caaccggctg ttcattaagc aatgattgtt caataaaaga ggtagttatg 1709161 ccggcaagga ccgacaatat taattgatgg ggttgaatac gtgattttag tgatgacaga 1709221 gcgttttcgg cgtcttttgg cttcattgcc aaaatgagca catccatgtc ttcaatacat 1709281 agttggttcg gcaaggcgcc tttaatgcca tattgaagtt caagttcagt taatcgctct 1709341 gtattgctgc ggtttgtaac gcagatgttt tgtttcggga ttttgttggc tcgaacgata 1709401 cctgatatca ttccttccgc catagatcct gctcctataa aggctacttt cttttgatca 1709461 aagatcggta acatctcctt tgttcgcttt tttgttcgca ttttcacacg tttaaaatgt 1709521 taccacgtga ggaaatgatg tcaagtttga aggccattat tgatttgtat tgtttctttt 1709581 cgacaaatat gtataatgaa aagcagaaaa cacccggttc acactgctgc gccgggtgtt 1709641 tgtttctatt aaaaattatc tgagagagct ttttcaatca gttttttaca gcgatccagc 1709701 tctaccttca gctgtttttt atatagcttg gcagcttcgt aatctttaaa ttgatagagg 1709761 acgacttcct ggagcttagc cccttctttt tttactttaa tttgttttag tatcccgtca 1709821 tcaagaagct catgcaaaga ccggtatact tctgtatgat ttggtttaaa accaatctct 1709881 ttaaattcag accgaagtac ttcaagcagc tttaacccat agagtctctc ttgctctgtc 1709941 atcgttatca tataaagctt caaaaatgcg cgctgtttca ctaaaaagcc tgttgaactc 1710001 cttttttctt ctttcatcat atgcactcct tcttctgtca ctgacaacac tatgtactaa 1710061 atattcaatt ttcttttatt gttttccttc tttatattaa agactgatag tccagttatt 1710121 tcatgtttac tgattatagg tgtagcggaa aaaataaatt tcgactgaac atttggtaca 1710181 tagttttctt agttctatta tagcctgcat ttactgctat cttcaattta aacgattgcc 1710241 agggtttaca tatctcattt taccggtacg gatttcattc aaataaaaaa acctgtcgaa 1710301 agacaggttt tcatttttaa ggatttgttg accataatcc cgctgttttg atgaaaatac 1710361 gaggatctaa tttcagttgt gccaccatgt actcagcaag atcctcaggc tgcataactt 1710421 tttcaggatt accgtctgtt aagttcaatt cgatagacat atcactagcg acagtgctcg 1710481 gcgttaacgc gctgactctg atattatgtt ttctcacttc ttgcataaga gactctgtta 1710541 acccgagaac ggcaaattta gaagcgctgt aagcacttgt tacagcagct cctctttggc 1710601 ccgctgtaga tgaaatatta atgatgtctc cggctttgcg ttcgatcatt tccggaagca 1710661 ccgcgcgagt gacatggtac acacccatta ggttgacttg aataatattt tcccactcat 1710721 cagctgacag atctaagaaa ccgccaaatt tgctgatgcc ggcattatta atgaggatat 1710781 cgatatcacc gagctgttcc ttcacttgag ctacagcttg gttaacctga tcggcatctt 1710841 ttacatctgc agcagcaaat gcagctttta caccaagcgc tttgacttct tcagccactt 1710901 tttctacatt agcggaagtc cggccaatta acccgatatt cacgccttct ttggcaagcg 1710961 ccagagcagt agcgcggcca attcctctgc ctccgcctgt gattagtgca gttttatgtt 1711021 gtaaactttg caattgaagc accctttctt tgtttacata tgtacgatat cacattataa 1711081 gtacaataca tccaatacgc aaatcaaacg aactgtgtaa atatcatttc ttctgattaa 1711141 aaaaacggat acagggtaat gacataagaa aaggagtgaa catatgatta tagtttatat 1711201 cagtcttgca gtattagcag tttctattat cttcttagga gttaccgtga tccaaaacaa 1711261 gaaaaaaata gaccccgcac taaaggagct ttcctctgtt acgcaggcta tgcaaaaaca 1711321 aatcgaagga ttaaaaacag aaacagagct gctgacgcaa aaacaaaaga agattcagca 1711381 ggatgtccaa ataaaaaaat acacgcttca gcagaccgca gctgaagtga aagaagttcc 1711441 ccaagcagtc aaagaggtgt ggcaggcagg acattttaat agcagataag gatgaatgag 1711501 atcccgttgt tacgatcaga atggacaaat gggatctcat ttttcgagga ggcttacaca 1711561 tgattataaa ccgcagctgc ttaaaagagt tcgcagaaaa agtacatttt cttccctctt 1711621 cacttacaaa gtccgattta cttactgatc catttcgtct ccatcaagaa aacgaacttg 1711681 gcatctacta ttcacctcat aatgaattta tcaatcggga tgcctcgctt gtgattgccg 1711741 ggatcacgcc tggtttttcc cagatgaaga cagcgtacga aacagccgcc gaaagcctgc 1711801 tgcaaggcgg gactcttgag caaatggcag tagacacaaa aatagcagcg ggtttctccg 1711861 gatcgatgag acataacctt attaccatgc tggatttatg cgggctgccg caagcttttg 1711921 gcattcaaag cgccgcaaag ctttttggag aattacggca tatgctccat acaacttccg 1711981 ttattaaata tcctgtcttt atccagcaaa aaaactatac cggatacaaa ccggctatca 1712041 ctcattctcc tatcctaagc acttatgctt ttgggcactt ccctgcagag cttaaccatg 1712101 tgacgggacc agctcttctc attccgttag gaaaagcggc cgaaacagtg tgtgaaacat 1712161 tgatcagaca gcacagcctc cagaatttga tttgccttaa cggctttccc catccatcag 1712221 gcgcgaacgg ccatcgtttg aaacaattca gcaaaaacaa agagcaacta gaaagacaaa 1712281 ttcgttcctt tgctgcattg gttgatttcg ctatagaaaa gaggaaataa aagggatatg 1712341 ataaacaaaa acacaaacgt ggggagtggt tgaatgtttc ctatattaga aacggatcgg 1712401 cttatactta ggcaaatcac agatcaggat gcggaagcca tttttgcttg tttctcaaac 1712461 gatgaggtga cacgctatta tgggcttgaa aacatggaat ctatagaaca ggccatttca 1712521 atgattcaaa cgtttgctgc cctctatcaa gaaaaacgcg gtatacggtg gggaattgaa 1712581 agacgggaca ctaaagaact gatcggaaca attggctttc acgctctggc ccaaaagcat 1712641 aggcgcgcgg aaatcggtta tgaaatcatc ccggagcatt ggcgaaacgg atttgcatca 1712701 gaagtcattt caaaggtcgt atcttacgga ttttctgccc ttggactgtc gcgtattggc 1712761 gcagttgtat ttaccgataa tgaagcatca aatcgtctgc ttctaaaaat ggggtttcaa 1712821 aaagaaggcg ttttaagaca gtacatgtat caaaatggga ctccatatga tacaaatgtg 1712881 tactctattg tgaaaccaag agaatgacgg tattctcttg gtctgtgcca catccctttt 1712941 cctttaaaaa gataaaaagc gcccctcaaa cagggcgctt tctaattaag atgcatattg 1713001 aggagatgtt tcctccttaa ctgctttttc ctcaggtata tgaatacatt ttgtcaagac 1713061 cgcacttgca aggtaaaggg ccgcaaagat ccagacgaca ccttgcgcgc cgacgagacc 1713121 gatgaacagc caagcgagtg cagggccgac aaacgctgat aaacctgcag ctaaattcaa 1713181 tacagacatg gctgcccctt tatcttttcc tgccaccgtc ggcacaattg caccaatcgg 1713241 cacatagcct gccagcaaac cgccccaaat aaagccgatc acgctgacaa ccgctaaact 1713301 tccgccggag aaaacaggtg cgtagtataa taagacggtg aaaatgccgc agccgactcc 1713361 gccgaaccaa ataacagtat ttttccagcc gaatttatcg ccgacaatac cgaagataag 1713421 gttaaacaca atgttcccca ggaaaatcgt tccccaaatt tgcagccaca cattggttga 1713481 aattccatgc tgggccatgt gcatcggcaa aaagactgga aaaccatatg taccaatgct 1713541 gttgatgatt ctgatgattc cgcctgtaag cacgcgcgga tttgtaaata gaatcgtaac 1713601 cccttttaaa agctcctcgg ctgtttctga tctttttctt ttcttctttt caaaacggtc 1713661 tttattgata aacaatgcaa agaatgcacc gagacatacc cagaaaatag agctccaaag 1713721 cgtattcaaa taaccgaacg ctttgatcgc gtagcttgag taccaagcgc cgaacacaaa 1713781 catgccgagg caatatgcaa tccaaaacca gccgacagca gtgctcagtt tgctttgcgg 1713841 tgttctgtaa atgacccatg tcaagaaaga ataagcaaaa agcgggtaac ctaacccttt 1713901 tacgaagtaa gtcacataca tcactggcag gttcagctgt tcaaatccaa atacgataaa 1713961 agcagctgta ccgatcacat aaaacaacag ccccataaac atcgttcgtt ttgcgccaaa 1714021 tgcttcgaga catacacccg aaaaccagga agctatggca agcgcaattc cgtatatact 1714081 aaaaatggaa gcggactgct gaacggtgag cccgttttcg atcaaaaaag gactgagcca 1714141 gccttgttca aggccatctc ccatcataaa caaaacaacc cctaaaaatc cccaggcaag 1714201 ccgcttcggt attcctattt tatccaacat atctgtctcc tccttagatg ctattattca 1714261 ttaccgtatt accttattaa agttgaaaat taaatgattc ctcaaaacag cagaaattcc 1714321 gtcttaaatt aatactttgc tttctgatcc tgaaaaaaag cgctgtgttt gcttccattc 1714381 ctcatataaa gccaattcta tctgacagtc cttcggttcg atcacccgga catttgctga 1714441 catctcctcc gttaattgaa aggtttcatt gcaaatgact gcagcaccga cgacagatgc 1714501 ctgatgatat ccctcttgga catagacctt tttttgaaga agatccgcga tatattgagt 1714561 gagcgctttg ctttggaatc cccctccgca cacccaaaca taatcacgtt caaacggagt 1714621 aacctctgtt aaaatgtcaa agttccattt gattgaaaat gcgatctctt ctagcgctgc 1714681 acgtacaaaa tgtgccctct ttaaatgtgc tgacagcggg gcatcaaaaa gaaaaccgcc 1714741 tctcgttaac gcattctttt cagccgataa ataagagccg agagccgcta cacatgcatg 1714801 gtcttctttt gcaagtgcag aaatctcctc ctccattact tcgtacgttt cattcggata 1714861 aaaaatctgt tttaattttt gataattcaa gccggtaatt cccggattcg tttccacaag 1714921 ccaatgccct tgatccgtat gacagttcaa ccaggcttta tgttttgtgt cgccatgatc 1714981 ctcagtaatt ttggttattg gcgttgttgt ccctgataca atgacaatgt cctcaagtcc 1715041 agctccggtg cttttgacag ccagctgtgt atccccgccc cctgctataa ccttagcatt 1715101 tattgaaagg cctaattcgg atgcatattc atttgctatc gttccaattg ctgttcccgc 1715161 tcttacaaga ggcggaagga tagatggaga aaagccgaaa atgtcgcaca tctcttctga 1715221 ccaagtgttt tgcttcacat caaatagcag ggtttctgtt gcctgtgatg gttcatatgt 1715281 taatattccg ctcagttggt acgtcaccca atcactgatg cttgtaaagc ttgcagtctt 1715341 ttcccataaa gagggctggc gctgttttaa tccataaagc ttgagcgcag aaaaaagtgc 1715401 agttggcagg cggcctgtgc tgctgtatat ctcttcccaa tcgggaatgc ccgcctccca 1715461 ctctcggccg cgattatcga tgttcggcag cccgagaaaa ggattgccgt tttgatcaat 1715521 caaaacaatc ccctgtcttt ggctcgtcga tgtcaaacca atgatgtcaa tatcacacga 1715581 acgggatagc gcacgttttg ccaaattcat cacctgcttc cacagcacct gaggagaaaa 1715641 ataacggctg tccgggtaaa gcgtctctgt ggaatactcg atgtcctccc gttcaactgt 1715701 tagaacactg ccagttacac tcacgaccgc taccctcgca ttgcctgtgc caatatcaaa 1715761 aacgagatag cctttttgtt ttttcattct gttagcctcc tttcttatcc ccctgttttc 1715821 agtgcgtcct tgttatacat tgtctgaata ttaagagttt tttcaccctt ccactttttg 1715881 agggctttat tcagtatcgt cacgtgatga tcctccactt caaatgttgc tccagcgaga 1715941 tgcggtgttg ccagaacatt aggcaatgaa atcaattcat aatctgattc ctctggaggt 1716001 tcatgataaa aaacgtctag tatcgcaccg ctgattttat gttcttttaa tacaaataaa 1716061 agatcttcac ggtttacaac aactgctctt gaagtattaa cgaaaatcgc actctctttc 1716121 atcagatcaa aatattgccg atctatcagt ccgagtgttt cctcagtgcg aggcagatgg 1716181 acagaaacga tatcgctgtc tgaaaacacc gttttaagag atgctttttc atacaacgga 1716241 tgatcgtctt gaatgtatgg atcgtaatat tttatcttac agtcaaacgc agtcagcagt 1716301 tttgcaatcc tttgcccgac tgcgccgaac ccaatcatgc caaccgtttt tcctgttagc 1716361 tcatttcctt taaatttgac ataagcctgc aggtaatcac tgtcccactc tccatccttc 1716421 agccactgat tcgaggcgct ggtatggcgc agaaaggaaa tcacatttcc aataaacatt 1716481 tcggcaacgg cttgtgcatt ccgccctggt gtataaaaaa caggtatgcc cctttttgag 1716541 gcagctgcca catccacatt tgagggcatt cccctgcaaa caccgacaaa tgaaagttcg 1716601 ggaacagaag caaatacgct gtctgttacc tgatcaagtt cagtaatcaa gcctgtcgca 1716661 tttgttgctt ttagcagctg aatgagttca tcctcccgat atgccctacc ttgttccttc 1716721 caagattgat aagcaactga gccaaacaag ttttcaagct cttttcgtcc ttcttcgttg 1716781 tacggtgctg taaccaaaac cgtcatgctg caaaacatcc ttttcatcgt atttttcata 1716841 aaaaaaatct ctttccgaag atggaaagag attcatatat aggcgcgctc tgttacaggc 1716901 agacgccggt ataaaccttg ctttcctatc tttcaagcta gcgcttgctg gaattggcac 1716961 aataatgttg ccgaggtttc atagggccag tccctccacc tctctggata gaaaatattg 1717021 agtatgtaat tttcagaatg aagaatacgt ttatcataaa gaagactcag attgatgtca 1717081 atctcttttt ttcagaattg acgttatcat cggaaatgtt ataattctta caaaatatct 1717141 aactagagag aggaactggg ccatgagatc ttttgccaca caacaaaacg gcattttcaa 1717201 atccgtttgc tcgctggact gcccggatca gtgcggattg ttaatacata aaaaagacgg 1717261 gaaaatcgta aaagtgcaag gagaccctga tcatcctgtc acagctggaa acatatgcaa 1717321 caaagtccgg aatatgacgg agcgcatcta tgatgaaaag cggctgacta caccgctcaa 1717381 acgaacaggt gcgaaaggcc aagcgatatt tgaaccgatt tcctggaaag aggcaatcga 1717441 tacgatcacc tcccgctgga aacagctgat tgatgaagag ggagctgaaa gcatacttcc 1717501 ttacagcttt tacggaaata tggggaaatt gacagctgaa ggaatggacc gccgcttttt 1717561 ttaccgcatg gggtcaagcc agcttgaacg gacgatttgc agcaaagcgg gatctgaagg 1717621 ctataaatat acaatgggca taagcgcggg aatcgatcct gaggaaaccg ttcatacaaa 1717681 actatttatt ttttggggaa tcaacgcggt cagcacaaat atgcaccaaa ttacgatcgc 1717741 ccaaaaagcg cgaaaaaaag gtgccaaaat tgtcgtgatc gatgtgcata aaaatcaaac 1717801 aggacgtctt gcagattggt ttatcccaat aaaaccggga accgacagtg cacttgctct 1717861 tggcatcatg cacattttat ttaaagaaaa ccttcatgat gaagcatttc tgtccgagta 1717921 cacggttggc tatgaagagc tccgtgaaca cgtgaaacaa tatgatcctg aaaaggtatc 1717981 gacgatcacc ggtgtcagta ccgaagatat ttaccgactg gcaaaaatgt acggggaaac 1718041 ctccccttct tttatcagaa tcggaaacgg accccagcat cacgataacg gggggatgat 1718101 tgtaaggacg attgcctgtc ttccggcgat caccggccaa tggctgcaca cagggggcgg 1718161 cgcaattaag cataacagcg gaattttaga atataacaca aatgccttgc agcggcccga 1718221 cttattgaaa gggcgcaccc cgaggtcgtt taatatgaat cagcttggca gggtgctttt 1718281 ggaaacagac ccgccgattc gctctctatt tatttacgga acgaaccctg ccgtcgtcgc 1718341 gcccgaagca aacaaagtca gacagggctt gctgcgggaa gacttgttta ctgtggttca 1718401 tgatttgttt ttaacggaaa cggctgcata tgcggacatt gtactgcctg caacatccgc 1718461 ttttgaaaat actgattttt acacctccta ctggcaccat tacattcagc ttcagcagcc 1718521 ggtgattgag agatatgggg aaagcaagtc taacactgag gttttccgat tactggctga 1718581 agccatggga ttcacagacc aggagcttaa agattcagat gaagtattaa tccgccaggc 1718641 gcttgaccat ccagataatc cgcatttggc agagattgat tacgattcac ttactaagca 1718701 ttcatttatg aaagcgaaac gtgaaaagcc gctgtttccg ggcgaacttc caacgccaag 1718761 cggaaaaata gaattatatt cagaaaaaat gaaacaagac ggcttccctg ctttaccgac 1718821 atatacacct cttgtaaccg ataatgaaca tccgtttatg tatgttccgg ggccaaacca 1718881 taatttctta aactcaacat tttccaataa tgaaaaacac atcaagcttg aaaagacgcc 1718941 aaagctcttt atcaacacaa aagatgctga aaaacacgga atcgttgatg gggcacctgt 1719001 acgaatttgg aacagccggg gagaatgcga gctgaccgct gcagttggag aacaagtgct 1719061 gccaggtgtc gttgtcagcc aaggattatg ggcggatgaa caaggaaaaa aacagcttgt 1719121 aaacgcgcta accccagatc gcttgtccga tatgggcggc ggcgccacct ttttttcagg 1719181 ccgtgtacag attgaaaagg tttgaaaaat aatgaaaccc ggagtatgcc aagcccgtat 1719241 aacataacat cgacataatg gaggcataca catggacgtt tttttaggaa ttggtattgc 1719301 tttggctgga tattttatcg gtgaaggctt aaagcagagg aaccaaacca aaggtaatga 1719361 acaaaatgat atcttcctaa taaaagaacg ggatatttac ttttacattg gacttttttt 1719421 aggaataaca acgactgaag caaaacagtt agctggagac atggcagacc tgccttacat 1719481 cgaaataaac ggaaaaaaat atgtccagaa acatatgtta aaagattgga cattcacatt 1719541 agttgaaaaa catcagggtg aataaaacaa atctgaggag agcgagattc attgtcacgc 1719601 tctcctctgt ttagctgtat ggatcctgcc accaaaactt tgtgctataa gcgctgataa 1719661 aacgataaac caccatctat gttctttcct caaacaactc aagatgcccg ttccacaaca 1719721 atagttttta tattcctttg atgacgtgat gttcttgatg aacgtatgta tcgtaaaaca 1719781 cttagaaaac ctattcggtt tgaatgtgtg ctctcattat gcccccatac tgcgccttta 1719841 tccgcggagg atttttttaa aaaaatatga aacctaaagc ttttagatcc tgaattttta 1719901 ttgaacctcc atatttctcc gattggtaaa aattagccta tacaccggaa gctgtacgtt 1719961 tataaaggat cagagaatcc cataaccagt aaatcactgc agccgcaata cttaacatat 1720021 aataaaagta cgattgcaat gtccatgcta ttgacgcagg ttcattgata acaaaaaaca 1720081 ggaaagctgc gataaaagca accacactgt aaatcaatag gtacatgaca ttgaaagttc 1720141 tcgctttttt ctgcaacttc atttggagcg gaacagcaaa aaggccatac accacaaaac 1720201 cgtataataa agcaattgct gccgtaaaca atgcaattat catatcgcca tacataacga 1720261 aagaataaaa ccctaataac aaaccaaatg taaggctgga tagccctaat gtcattaaat 1720321 aatatgatgc gatttttttc attttttcac cccccttgtt tgatttattc acagtgctgt 1720381 tagtataaat tcacaacctt tgtatttctt ttatcgagat gtcttcccta acgtgctata 1720441 cgcaatgcgc taataaaagg tttcaaaaat gacgttcttt tattagataa tacgctggct 1720501 gaaaacgcct ctcctgattg gccaaagcgc gaatgaaaaa agtgcatgaa tacctgccca 1720561 acagacagaa taagaagagt tgatatttca acacttttcg taaaggggtg aaaccaatga 1720621 gtaagaaagg tattcaaaat tcaagtattg aacaaataag aaatgaccat gagactgaaa 1720681 cagcttttaa agcagatgat cctaaaaaac acggttccga tcctaaaaga acgaaataag 1720741 ttcttacccc cactaaaata tcaataatct ggaggaagta aagtgactca aaaaaacggt 1720801 gcagacagac ctgatgatta taaaagattt tcttcattag acaaggaata tgattttcag 1720861 caatctatac gcagcaatac tgagacagaa agtgtaaaca ctgaaacaca aactcataac 1720921 aaagaaaaca aaaatgacac aacagatgtt gccgggaaat actttgagcc ctcagattat 1720981 aaaggaagca cgcaattaga aaaaggattg gctgaaactc atgaacaggt cagcgatgac 1721041 tattttgaag ggacaatcga tcaaaatttg gactagccat acaaacggaa ctaacttaaa 1721101 agaagtcagt taactctgtt tttagaaaca accacagtaa aagtagccaa cccccaccga 1721161 ataagatggg ggttgcacgt aagtagcctg tttaatattt aaaacgatta atgacggttt 1721221 gaagttcttc tgccaactga gatagagatt ctgcggcata ggagatttcc cccattgaat 1721281 gaagctgttc ctgtgatgaa tttgcaaccg cttctgtatt tgctgacgtt tcttttgtac 1721341 cagcagccaa tgtatgaact gtgtgctgaa tcacttcaac gcctgaagta agctgttgag 1721401 ttgctgctgc aacttcttgt atttgagaag tgacctgttc caccaggttc agtatttcat 1721461 tgaaatttcc tgttgtctct tgagaaagaa caatacctga gctcacattt tcttgaacaa 1721521 ctttaatatt atttaccgtt tctatcgatt cgttttggat ggtcgctacc accgattgga 1721581 tgtggtttgc agatttattt gtttcatccg ccaacttccg aacttcttct gccaccacag 1721641 caaatccttt tccttgctct ccggctctgg ccgcctcgat cgctgcattt agtgccaaca 1721701 aatttgtctg ctctgaaatc gtcgtgataa gcgaagagat atcgctgatt tctgctgtgc 1721761 tcgctaccaa tgtttgcaat ccattgccgg ctgaatctac agatttatca atgaatttca 1721821 tctggtctaa catcttgttg acggacttag agcctatttc agccttgtct ctcatcgaag 1721881 aagaaagatc cgctatgttc cctgtatttg aagcgactga tgatatactg tctaataatt 1721941 cagtgatgga ttctgcgctc ttttctgtca ttgagctttg cttcacattg ctgtcggcag 1722001 ccatctgcat ggctcgtgaa atatgttcag atgttgattt cgattcttcc gcgcttgccg 1722061 ataattcttc agaggaagcg gcgacttgtt cagatgagct gctgatctgc ttcacaattt 1722121 gagttaatga atgagtaaaa gaattaaaag attgggcaag ctggccaaat tcatctttat 1722181 ttttcacaat gacttttttg gttaaatcag cctcgccgtg tgcaatttcc tccagctgct 1722241 tatttatgct tcttagtggc accataatgg actttaacag cattatgctt agaacaatgc 1722301 ctaatattac tgatatccct gtgacaatga taatgagcga ttgactcatt ttcccattgc 1722361 cctgtatttc atcctttaga tcctctacct cttgatccag gcgatcagac agcttattga 1722421 cagccggagc tacgccttct tttcttattg ttctttcttc tccaaaatgg atggtttctg 1722481 cttttttagg atttgaagag taggctgtta ctacttgctg attcaaagct ctatactgag 1722541 taaaacttgt cttaatgtct tcaatattgg attgatactt ctcttcatca atcaagtcat 1722601 taacccggtc aaggctcttt aagacatcgt ctgcttttcc cttcataccc tcgtcgtatt 1722661 ctttgtctct ggtaatcaag aagcctcttt catcatttga taacccggtc aattcatatt 1722721 ggatgtgttt tatctctttt tggaattcca ttttgtcttt aagttcttca ttctttttca 1722781 cagtagaaga aatcataaat actgaggagc ctccaattcc aataattgaa acaactaata 1722841 ttgatataat ccccagcaat tttgttttca ctttcatgtg tcgttttccc tttccgcaca 1722901 atgtaatggc tgaaataaaa tatgttcaag cgcgtttgaa tccaattcgc ttacgctcat 1722961 gtccataata tcgacacgtg ttatcaagtt ttatagtgat attcttatat gaataagcaa 1723021 attctttacg tctctgaact tacagaaaaa ccttaagtaa aatttgcagt cttttgcggt 1723081 atgtaagtca ctcttattcg tttttctaaa aaaggctttt cccacctcaa attggctgaa 1723141 ccggctgttt tctcgaaaat ataatacaat acgcagcata atatgaagga gcgaaactta 1723201 aatggggatc atcaatggta aagaattcat tgaccgattg aataaactag aaaacgaaat 1723261 atggtatgat ggcgaaaaaa taaagggtaa catttctgag catcctgcat ttaaaggaat 1723321 aatcaaaaca aaaagctcac tttatgaatt gcaaacaaag gatgagttaa tacatgaaat 1723381 gacttattgc cttcctggag atcataatcg aatcggcctt tcctatctcc agcctaaaac 1723441 aaaaaatgat ttgaaaaaaa gaaggaccat gattgaacat tgggctagac atactcatgg 1723501 aatgatgggg agaagtccgg attacatgaa tacggttatg atgagctttg cttcgtcagc 1723561 ggagcttcta aaagataaag agaattgctt tcctgaacat atactagata tgtatgaaca 1723621 agctgctaag catgaccttt cctttaccca tacattcatt actccgcaag tgaaccggtc 1723681 acagtcctat tttgggctaa gtgaaaaacc gatatctgct aaagtcattg atagaaccga 1723741 aaaaggttta atgattcatg gcgcacgact gcttgccaca caaggcgggt tgaccgatga 1723801 aatcttggtt ttttcagcgc ctaaattttt ctttgaaaca gatgaagctt atgctttttc 1723861 aatcccttct aatacaaaag gcgtaaaatt catcacaaga gaatcatttg tattaagcga 1723921 ctcttccttt aatcatccct taagctcaag gtatgaagaa atggattcaa ttgtggtttt 1723981 tgatcatgtg ttagtgccgt ggaatcgtgt gtttttttac gataatgtgg aagcagctaa 1724041 agattttatg acaaaaagct cttttcatgc ctttaccttt caccaggttg tcattaggca 1724101 aatgataaaa attgaatttc tattaggtgt tgcacagctt cttgtcgaca ccattaatgt 1724161 ttccgaatat cagcacatcc aagaaaagct ctcagaaatc attgtgggat tggaaacaat 1724221 caaagccctc attgacaaat cggaaaatga tgctcagtta gatgaattcg gctatatgcg 1724281 cccctgttta attcctcttc aagtcatcag tacgatcatt cctaagctat atcctcgatt 1724341 tactgaaatc atacaattaa ttggagctag cggaatggtg acactgccta ccgaaaatgc 1724401 atttgactca gagatacggg aagatcttga ccaatatctt caagcaacca atacaaatgc 1724461 tgaagaacgt gtgaaaattt tccgtttggc atgggattta acaatgagtt cattcggaac 1724521 tagacaaact cactacgaaa gatatttttt cggagatcct attcggattt caagcaggct 1724581 gtataccagt tatccaaagc aggagcagtt gaacatgatt aaaacatttt tacatgcaga 1724641 tacagaacat tgaaaaaaca gcgggaaaag atccgctgtt tcgtattttt tattcaggaa 1724701 actgaacatg gcccggtact gtataggctt tggacgttcc gctttcaggc agctttggaa 1724761 tggtgtcttt cacaactttt ccgcggatgt cagtcattct gactttgaga gagccagtac 1724821 ctaaattcgt actcacaaaa tggttatagt ccattttctc catgttgatc cacttaccat 1724881 ccttttcata ttccattttc ataacaggat acttgtgatt tctgacttgg attgctgccc 1724941 accacctgct gctgccttct ttgatccggt acgtgaaatt gccggtgatt ggggctttga 1725001 caacacgcca tttaatattg atttttccgt ctttcatatt gccgatttta cggaaggcat 1725061 taggtgacag atcaagagct ccccgagcgc cttcgggata aagatcagta acatatacgg 1725121 ttgttttccc ttttggccct tcaacttcca aataagagcc ggcaagtgcc gcttttactc 1725181 ctccgtaatt gagatccgcc ggatttattg cagtaatctc catatcggaa ggaatgggat 1725241 ccagcaggaa agctcctcct gaatagcctg accctgtata cgttgcataa ccttcatgca 1725301 ggtcgtcata tgctgccgaa gcttgcgggg aaaaacagaa gatcgtcaac aaaaccatac 1725361 caacaaatgc actcatgatc tttttcatat ttggtcctcc tcaaaccaga cttcaaatga 1725421 gaatcattat cattataaga ctcaatccat ctggtttgaa agaggaaata gattcatagt 1725481 tgattttaag gcaaattcac tatcattcat atatcaaatg taggtactta tgaaaaagcc 1725541 aatacaaatg aacgaatgtg cacttcagcc gaatgtctta tttttccctc tcaaaattcg 1725601 catttcaata acgaaatgaa acaggctgtt ggcctgataa cagctataca ggaaaagcta 1725661 tttttccccg ctcagtttca acttagctgt catcatgatg ccaaagatca gcacaatcgg 1725721 aacccaaata atgaagtgat aaaaatcagg ctcagccaga gcaacaataa tagcccctac 1725781 acaatacaaa ataatagcca gtgctcttaa cacagtatct cttaagaaag tcttcttttg 1725841 cttcttaaaa aacaaacggc cggatatatc ctctaaaaga gaagccaaag tgccggtcaa 1725901 cacagttgaa gaaatacctg caatccccag tttttttgct gctgtagttt gaatccccat 1725961 agaaatgctc atgagtataa ttagaatgtg cacaggaaca aatgcccggt aaaaagaaag 1726021 acaagcaaag acaaacaaaa tgaatgcttc aagtgcgagg gcttttgtca cagcagaagg 1726081 ccaaagggta ttttccgcct ttccgaccat caatgtagca atgatcacgc cgcatataaa 1726141 tccgattagc gcagtcaagg aattaaaaac agtgacctga atggatttgc cgatagctaa 1726201 ccccaataat acaatgtttc cagtcatatt agctgtgaac acatgtccca ggcttaaata 1726261 cccgattaca tccacgattc cagctgttaa acataaaagt gatagcaagg tgtttcgata 1726321 agctgctgca gtcaacggtg tatcaatcct ttcttctatt tcaattgtta gtatgtcttt 1726381 tggcgcaatc tctatttttt aagtaaccca acattaatta ggaagataga acctattatt 1726441 cctttccatt aactgtaata ataatccccg caaggaaatg attaaaattg aaaggaagca 1726501 tattgtgatg aaacgacttt gtttatggtt caccgtcttt agcttgtttt tggttctctt 1726561 gcctggaaaa gcattaggtg cagtcgattt tccgaatacc tcaacaaatg gccttttagg 1726621 ttttgccgga aatgccaaaa atgaaaaagg catctctaaa acgggcacaa cgggtggaaa 1726681 aaacgggcag attgtttaca ttcaaagcgt aaatgattta aaaacccatc taggaggatc 1726741 cactccgaaa attttagtgc ttcaaaatga tctttccgca tctgcgaaaa caacagttac 1726801 cattggctca aataaaacac tcgtgggctc ttacgcgaaa aaaacgctga aaaatattta 1726861 tttaacaact tcatcagctt ttggaaatgt catttttcaa aatttaacgt ttgaacacag 1726921 tccgcagatt aacggaaata atgatatcca gctttattta gattccggta tgaactattg 1726981 gattgatcac gtcacattct caggtcatag ctataatgca agcggaagcg atttggacaa 1727041 actcgtgtat atcggaaaat ccgcagatta tatcacgatc agcaactcaa aatttgcgaa 1727101 tcataaatac ggtttgattt taggataccc ggatgattct cagcatcaat atgacggcta 1727161 cccccacatg acaatcgcca ataattattt tgagaacttg tatgttagag gcccaggtct 1727221 gatgagatac ggttactttc atgttaaaaa caattacagc aataatttta accaggcgat 1727281 tacaattgct acaaaagcaa aaatatattc cgaatataat tactttggga aaggcagtga 1727341 aaaaggcggc atccttgacg acaagggcac tggttatttc aaagacatag gcagctatcc 1727401 atcactcaac aagcaaacct ctccgctgac ttcttggaat cctgggtcaa actatagcta 1727461 tcgtgtccaa acgccggaat atacaaaaga atttgtcacg aaatatgccg gatcacaaag 1727521 tacaactctg gtatttggct actgatataa aagaggccct gcgttaaaaa cgctgtgcct 1727581 ctttttatac tataggctat ttttaagcga tccttgtaat tccatcaaga tccagcgtcg 1727641 gtcaaactaa aaagcatatg ttcttttcca caataacttc ttaactggct ttcttattat 1727701 accagtttat cgcaagtgaa aagaaatcat tgttctgaac ctgtattaaa tgaacgatcg 1727761 tcccacaaac tacttaaaaa cccctaaaaa ggatgatgga tatgtgcggc aggtttactt 1727821 tgtactctgc atttgatgat attattgacc agtttgacat cgatcaattt tttcctaaag 1727881 gtgaatacca gccaagctat aatgtcgcac catcacaaaa catccttgca atcatcaatg 1727941 atggatcaaa taatcgctta ggcaagctta gatggggact tattccacct tgggcaaaag 1728001 atgaaaagat cggttataaa atgatcaatg ctcgagccga aacaattacc gagaaaccgg 1728061 cctttcgaag accgcttgtc agcaaacgct gcatcatacc agcagacagt ttttatgaat 1728121 ggaaacggct tgattccaaa accaaaatcc caatgcggat caaattgaaa tcatctgctc 1728181 tttttgcgtt tgctggctta tatgaaaagt ggagcacaca tcaaggatac cctctttata 1728241 cctgcaccat cataacaact gagcctaatg agttcatgaa agatatacac gaccgaatgc 1728301 cggttatatt ggcccatgat catgaaaagg agtggcttaa ccccaaaaat acaagccctg 1728361 attatctgca aagtttgctg ctgccttatg atgctgatga catggaagca taccaggttt 1728421 catcattagt aaattcaccc aaaaataatt cagctgagct tcttgatgca gaaaatcata 1728481 tgtagtgatt gaaaaaattc tctagcaaga acttgtcaaa tagctttgtt ccttaggtgc 1728541 caatccctct agtaattatg aatatttagt acatagatca attagttatc tttagcatca 1728601 gtttgaaata attttattat gtaaacttaa ataagcaatg ttattccttt catataaaat 1728661 agtttacatt tttataaaat cgcttcactt ttctattttg tcagcaaaaa aactgaacca 1728721 cattaaactt atgaaacctg ccgcacctgt ggattgcaaa tatgatataa gcccatagag 1728781 gtaaatccat acactttccc tcctaagaat taaatgaaat ttctttcatc ttacatgaag 1728841 gtcttctttc ttttgtttat ccagtgtaat acttaataat atgttgatga atgcagctgg 1728901 aaaatatata aatcccactc caagaatgcc tagtatcgta cttaaactta ctatgtaatt 1728961 ctttgtcatc gtttgactgt caatcaatat tagaagtgaa atcaatccag ctaaaacacc 1729021 tataaaccaa gcatcgccaa cagcataaga atcatccagc atccctaacc atcgccccaa 1729081 tatagagctc ccaatggcag tcaaactgga taaaaatatg agtgctttca tttcttctcc 1729141 tcctttaaag ccaatcaaac tggtagaaat cggccattga atccccatta tcgaatggtt 1729201 accatttcat ttccacatta acattttaaa gctcattaca atacgattca agcagaaaaa 1729261 ccctacataa cgtatatata gggatttaat aaaacacagg ccaaaattca gctctatcta 1729321 ctttaaaaag atatgaaggg cagctgtgtg atctgttacg tctttacgta ccgggatatt 1729381 tcacaacagg cactttcttc ttgcgcagag aatcaagcat gactgatcca gcattcaagt 1729441 tgctttgtac taattcttta ggcgtcaatg ccatccactg attgagtgac acatctgcat 1729501 agcggttact tttgaacatt tctaaaaacc ataatgtttc tgtaccagtg ttttgtatat 1729561 agtgtccggc attagaaggc acgtatccaa cgtcgcctgc tctataatca aatgtgcggg 1729621 cagtcccatt tccgataaat accgtcattc gtccctgtcc tgttagataa tattgccact 1729681 catcgctatt gggatgccaa tgaagctctc tcatcgcgcc aggctcaatc tgaacaagtg 1729741 cagcggctat cgtttttgaa attgggaagt tagaagaatc cacaattcgt acactccccc 1729801 ctggcatttg aattgggggt tgatttaaca gctcgtgttt aaaggtcatg gggacttttc 1729861 catatggtga ctgaatgtct tcactggcga ctgatcccgg cacattccct tggtagatat 1729921 agacttgctc agacggaaga gagttgaaag cattctccgg gacaccgaaa tttgcagaca 1729981 gaacatcttt tggtgtgtgt gcaagccaat ctgaaatggt taacgttgaa aactcagaaa 1730041 agttcccatc atcgaaaacg agcagaaact cgcagtgttc caatccctgt atggaatgcg 1730101 gaattcctgc cgggaagtac caaaggtcgc cgggaccaac atcagcaatg aaatttcgtc 1730161 cgtcttggtc aacagcggtg atacgtgccc gtcccaaaag catataagcc cactccgctt 1730221 gcttatgcca atgaagctcg cggacgcctc ccgcagttaa gctcatgttt acacctgcaa 1730281 tcgcagtcga aatcggaagc tgtcttacgg tgatttctct tgaccagccg ccgtgatcta 1730341 atttcatggg agcgtctgag aatgaaaatc tcaagttagg aatcataccc tcatctgtaa 1730401 caggcggaac aaatatattc ggattttgaa tatcccgtat tatatttcgc gggcctgtat 1730461 caatagctcc agctccatca cttcgaatag gctgcggcac gtttctgtct tcatgattga 1730521 ttggttgttg ttccaacagc atgcacctcg ttttagaaat gaacaagatt ttatttcagc 1730581 ctatgcagaa tcttagattg ctgtgcctag gaatccgcaa ataaaaaagt gaccaccaat 1730641 gtgatcacaa atacatcaaa taaactattt tttataccat ggcttcttat gtaatttgat 1730701 tgcttctgtc tgttttttct ggcctgtcct ccactccact tttactaata catcatgacc 1730761 tatcacttca tcttcaggca tataatcaaa ggtggaaata tggtcctcca tgcgtccccc 1730821 acccggcatt tcatcacctg tgtactccga taagtcgtac tcatctacgt tatcatcttg 1730881 atacttttcg ccatctacat acagagtaat tctttcaaca acagtccact tttcttcctt 1730941 cttactcccc tgccaatata gatttagaaa ataattgggt ccaattgaag ttttgtctga 1731001 tttttcaagg ttagacatcc acagtccgct tttcccgctg ccctcatatt tcactttgtt 1731061 ccctgacacc attacaaata atgtgatgat gcagatgatc aagaatccag caatgatcaa 1731121 tagccatttc ttaatattgt tcttttttct catgtttttc ctcactttcc taacttttta 1731181 gtaggaaaat acgatcaaaa tgttaccgaa aagaaaataa gaaagggcta atgatctaac 1731241 agatgactgt ctaaactttt gacttaaatt aaagtgcttt ctaaagacaa gattaaaacg 1731301 tataacagct cttaaatgca ttttttgttt cattgagtca agaaccttaa aatggctttt 1731361 tattattaaa aatcaagcta gtgtattaag taacttttca aatttattta tactcatgat 1731421 ctcgtgagtc acaaatctcc catcaaaaaa aacgctaaaa gttgtccaaa tagctggtga 1731481 cttttgtgcc tcttctttcg atgataactg aattgactga aattgaaccc ctttcttttc 1731541 agtcaattcc cgcaaatcat ttatcatgcc cactgcaaac ggacactgag ctgtatagta 1731601 tatcgtaatc cccttttcat tgatagaatc acttttcacc tggctcttaa atgcaggaga 1731661 atctgcaagg ccattccaag tcaaagccat taattgaaaa taaggggcag cttcatcttg 1731721 tagagtaaac cccatatgct caaagaaatg cttatcactt aaatagggca gttttttctt 1731781 gcctgcgata tggataatgc catccatgcc gcacgctttc gcatctgcta tacatttgtc 1731841 caacaatcgt ttcgcatgac cgttattttt atatctgcca gacacccaca gacaattaat 1731901 gtacataaaa ttaggcgcat tgataggcac ccatgcctca ttcgcaggta ggtattcaat 1731961 aaagactttt gcccgttcat gtaagcgata gaacaccaat ccttcatcca ttcgagcttt 1732021 gagccatctc ttcttttcat taactgcatg ctcatattgt ttcgtgctta atgcacagca 1732081 aatatgattg tcttcaatat tgtcctttgt gatttcaatg tagcacatct cctctttccc 1732141 ccctttaaca taattacatg gaattcaact tcacacttta catgcctaat agaataaata 1732201 cccgttccaa cttaaatact ttttcttttc cattttgcca attaactgta aaacccttct 1732261 tttattcaga tattatcttg attcctatat cacccatttc aaatccaaag tgtgttcatc 1732321 tttgaggatt agatgcactg cttatgctat aaatacagta cacgaagttt tttatttgaa 1732381 gtaatatttg ttacgggaca gcaatagtaa ataagtgata aaaggggaat taaacttggt 1732441 ggaaaaatgt tattcttgtt taatttgcgg atacaaagga ttaattcaaa atcctttgta 1732501 taaaggcgag tatcaaaaaa cgtttgacat ttgtccatgt tgcggttttg aatttggcta 1732561 cagtgaggat catgatgtga ggttaggttt tattgtaact cctgatcatt taattgaggc 1732621 tgcatttcaa ttgtatcgca aacaatggct tgagagcggg atggtaattg ctcatccgga 1732681 agatattcca gaagaattga aaaatggcaa ttgcttaaaa tttgaagttt tgttgaaaca 1732741 attgaaaaaa ctaaatcttg acatagaaaa ttttgaaatt agcggttttt aatgatgaaa 1732801 caggttgcac ttgtttaggt ttcactgtca ttatcagtaa aatgttaagt tgaaatgcgc 1732861 aatcagtcac aaagtctcta ttcgtattca ataaagactt tgtgatcatc gacaaacatt 1732921 tcactcccat cggataaagt atccaaaagg cctcctctgg ttcttctcta tagtcattaa 1732981 tcacagtcac tttgacattt gactcagcta tgattggttt tccaacaatt tttcgttttt 1733041 tcctcaggca aagtaagaga tcgaatcatc aaagccattc catctttact gtctaattaa 1733101 cgccatcttc agtgaattta aaggtctgtt ttaaattgcg tccttcttgc cccttctgtg 1733161 tccaaattat aacaacctct aattcagagg ccttatctgc cagcataaaa tgattgaact 1733221 tcagcggtga gccatcattt aaactttcag ctaacatttt agaatcttct tttggtttga 1733281 cacaattttc atcgggacat ccaaaaagcg aaaaccttgt gattgaatta gggtcatttc 1733341 tatacaattg cacatccact gtagctgctt tttcccctat atttttgact tccaaggaat 1733401 atacttgata ttctccttta tgaggtctcg taaattcctt tacatttttt gcttcactta 1733461 cttttactga ccactggtct gttttttgtg taataggcaa caccgtaaaa gtcagggcat 1733521 gcgcttttga ttggcaaaac gtaaatccaa ctgctgtaaa aacaattaca gaaaataata 1733581 cccttttcac ttcatttatc cctccttcct ttcactggcc gctccttaaa gaattgattt 1733641 tgagcaatct acaagctctc ttaaccaaaa ccttacctga ggttttgtct ttactgctct 1733701 gcatttattt ctttcggtat ccgagaagga gctttgggga tttttctcaa tctgctgtta 1733761 atcacatcag aagagtatag cgtaataatc atacttcccc catacctttt tgcccgaatt 1733821 aagattggtt ggttatattg gttttgaaag cgaaagtcag gacctcccca gcttaccgtc 1733881 gcatcccgtc cgggcggtac atatggtaca cttctagtat gagaatagcg ctgaacgatc 1733941 tgcagtcctg cacgatctac tgcattaaat agagttgagg acacctgaca aattcctcct 1734001 cctacacctt cagacaactc cccttttaca ataatgggtg cacttttata tcctttgttc 1734061 cgagttctca ttcccacaac ttggttaaac gaaaacgtct cattagggaa aacaacgtga 1734121 ttgtcgattg cttttgcaga aagagaaata ttgtgtgaac ggcttttatt gcttgagtta 1734181 aaatacgtca cgtactgacc aagctgctgc gtactgatgt gagctagcag ctcgctgtca 1734241 actttcggat aaatgttcat ttccggcact tctatcttgg agggaccttg cccataaaaa 1734301 tacgcataaa acttttccat aaacgcctgt tgatacagtt tgtagccaac cctgcccggg 1734361 acgatgcttc catgatcgtt aaggacagca tttatcggct cacggtacac tttctgatca 1734421 agctgtttga tgaatttact gtatttttca tagtcaacca ttggagtgcc gggaagaggc 1734481 attgtaaagt cttcacggtt aacagtggca atcgtccgtc cttgctgtgt gaccgttaaa 1734541 ctgtcctgcg gctcactcgg ctgagccaat aaaaaaagac cagtgatcaa aatttgtatc 1734601 ataagtcggt ttacctccca atcattagta tgaacagccg cttatccttt gatgtatttc 1734661 ttcccatcgt ttgtttgaat ctttagacgt tgataaaaac cttcataaaa gagcttagct 1734721 ttatgttcac accgatccct gagctcactg aggcacacgg ttcattcagt cggcaagttt 1734781 gaagtagttc agcatctccc agtgatgagg gatgcttttt tgtcttgtca aaaatgaaaa 1734841 gggtctccta taacaacaaa aaatcaatcc atttcaatat ttttttattg agaaacgata 1734901 aattttttgt tacattcaat tagacaacaa ataaatgagg tgcttgttat gaatcgaatg 1734961 tcgacaattt ttttaaagat agctttggtt cttattggaa ttccaattct tgctttatgc 1735021 atttttttag tgcctaaggt agccaactat tcagcagaat tatttccaaa tatcgcttat 1735081 ataaaatatc tcgttttcat ctatttgtat gtaacggcga taccttttta ctttgctctt 1735141 tatcaagcgt tcaaactttt aagctatatt gacaaaaaca aagctttctc gggtttgtct 1735201 gtaagagctt tgaagaatat aaaatattgc gcagtcacta tcagtatctt ttacgcagca 1735261 ggcatgcctg tcttttatct gatggccgag atagacgacg ccccgggtat cattgtgatc 1735321 ggattggtta ttatttttgc ttcaatggtg attgcggtct ttgctgctgt tcttcaaaaa 1735381 ctgttaaaag aagcgattga tataaaatca gaaaatgact taacggtctg aggtgatgac 1735441 atggcgatta ttatcaacat tgatgtgatg cttgctaaga ggaaaatgag cgtaacagag 1735501 ctttcagaga gagttggcat caccatggct aatctttcga tattaaaaaa cggaaaagca 1735561 aaggctattc gattatcaac tttagaagcg atttgcaagg ctttagaatg tcagcccggg 1735621 gatatattgg aataccgaag tgatgaagac acaggattcg taaagaaaaa atatgaagga 1735681 tcaacagaaa aataaagtga ttggcggtga gcttatggac ataaacttat atccatctag 1735741 ctgctatact aagcgtccct ttcatacacg aagaacacaa ctatggagga ggcatacatc 1735801 atgagagcca taaaacaaat cgtccatttt ggctgggaac aagccctttc atgtttgttt 1735861 cctgccgtta tttttgcctc tttggctatt acgcaaatca tcccactgcc cttcttgccg 1735921 cggtatgact ggctgctcat tatctgcgtt ctcatgcaat tgtggatggt gcgttccggt 1735981 cttgagacac gggatgaatt aaaagtgatc acattattcc accttattgg gcttgctctg 1736041 gaacttttta aagtccatat gggctcctgg tcttatccag aagaaggata ctccaaaata 1736101 tttggagtac ctttgtatag cggctttatg tacgcaagtg tagccagtta tttgtgccag 1736161 gcatggagaa ggcttaaggt tgaactggtt aagtggccgt ctttttttgc agttgttccg 1736221 cttgccgcag cgatttattt gaattttttc acccaccatt tttctataga cattcgatgg 1736281 tggttatcag ggcttgtcat cattgtcttt tggcaaacat gggttacata cgaggtgaat 1736341 ggagctcgtt accgtatgcc gctcgcactt tcttttatac tcatcggatt ttttatatgg 1736401 atagcggaaa atatcgctac gttttttgga gcttggaaat atccaaacca aatcgataca 1736461 tggagtctcg tacaccttgg aaaggtaagt tcatggctct tgctagtgat tgttagcttt 1736521 cttatagtag catcattaaa acaagttaag gagcagagtc ccacaaaggc agagatggat 1736581 gaatcttttt cttagcatac gcatacaagc tcccaaatag agtgaaaagc aacgttcaaa 1736641 tggttgcttt tttcttttat gtaactctgc cggtgagtat tcatcttctt caaatttcat 1736701 cgcaacacga taactgattc agattacaac tgctttcaac actttgacaa actcatgcgc 1736761 cgccggcgtt atctcttcaa atgaatgtgc gatgacgcca atatcgcgtg tgaccctagg 1736821 aaagatgtcc tttttaatca attgatgcgg gacggatgaa agtgtaaagt ttgaaatgat 1736881 gccgataccc aagttatttt tgaccatatt aatcaaggtt tcggcatttt gcacagttaa 1736941 gttttccttt aattcgatgt tgtattgcga aaatgcgttt gacatcgcga tttcatgacc 1737001 gcctttacaa aaaatgaggt catcttgata tgtttcaagg tcgacatgct tttcaagttt 1737061 taattcgtca cgctgcggcg ggatgacggc caccatatag tcgttacaca atagctgatt 1737121 ttcaaacggt tcaaatggag atgctgcgat cccgatatca accgtccgat cttcaaccca 1737181 tccttttatt tggtcagagg ttccttcgat caattctatg cggatcagcg ggtagtttga 1737241 tctgaatgcc gcaatcgcct gtggcatgat atttgttgaa actgcaggaa atgaaccaat 1737301 tttcaccttc ccgtttaaca gcttgttttc ccggttggct acttgatata ttttgctttc 1737361 aattcccttc atttgcctcg ccagcagcaa tatttctttt ccgatgtcag tcagcattaa 1737421 accatgatgt ttatccctga tcaataattt gagctgcagt gagctctcca ggttttttat 1737481 cgctttactt accgccggct gagagatgaa caattctttt gccgcttctg taatatttaa 1737541 tttctcccca acttttacaa atatgtgaag atggttcatg ttcataacca tttggttata 1737601 cccccaataa taaaaatgta tttcagttat acataaatgt aacatatgat agaaaccagc 1737661 acgatatttt aacaagaaag gcggcttcat tatggtaaaa gttatgctgg gaatcatatc 1737721 tgtcacactt atttggggtt atacttgggt tgcgatgaaa gtaggaattc atgacatccc 1737781 cccgctttta ttttcgggtt tgcgcctgtt catcggagca gttcctttat ttctcattct 1737841 cttcatccaa agaaaaaagc tttcaattca aaaagaacat ctcaaaagct atatcatcat 1737901 gagcctgttg atggggctgg gctatatggg gattttgacg tatggaatgc agtttgtcga 1737961 ttcagggaaa acctctgttt tggtatatac aatgcctata tttgttacgg tgatcagcca 1738021 tttttcatta aacgagaaaa tgaatgtgta taaaacgatg ggactggtct gcggcctctt 1738081 cggactgtta tttatatttg gaaaggaaat gctcaatatc gatcaaagcg ctttatttgg 1738141 ggagctgtgc gtacttgtgg cagcgcttag ctggggaatc gcgaatgtgt tcagcaagct 1738201 acaattcaag catatcgata ttattcacat gaatgcctgg caccttatga tgggagccgt 1738261 catgttattg gtgttttcct ttatatttga ggcggtccct tcagccgagt ggacatatca 1738321 ggcggtgtgg tcattgctgt ttaatggctt gctttccacc ggctttacct ttgtcgtatg 1738381 gttttgggtg ctcaatcaaa tccaagcgtc aaaagcatcc atggcattaa tgtttgttcc 1738441 cgtattggcc ctattctttg gatggctgca attgcacgaa cagatcacca tcaatattat 1738501 cctcggcgca ctgctgatat gctgcgggat ttttatgaat acatttacat tttcacgacg 1738561 gaaagtgtga atgatataca tttcccctgt catttgggct tcatgtgaca ggagaagact 1738621 attacgagaa agtcttctag aatcctgacg acagcctatt aaacaatgaa aaaagctaat 1738681 gtctgcatgt agacattagc ttggctggcg tttaggctgg tgagaatcca gatacttttt 1738741 tattaccatt ctggctgatc aaactgaaaa ccgtatagac cttttacttt aacatctccg 1738801 caatctggat cttttgtcaa aatcaaataa tgagtcttat aaggcatcgt ctcaactcga 1738861 tcagttgcac taaaatcaaa atgatccccc gagaagtttt tttcactaac ggttatttca 1738921 tatcctgaca aagtcattcg catgattctt gcgttaattg tacatccttc agtatcgaaa 1738981 atggtgaatc tgtacccaaa gtgagatgtc caatggtttg aatttaggtc atcagacttc 1739041 ataaaccatt tttcattctc tgtcattgta aaactcactt tctcctcatc tttcacgata 1739101 acggccgaag cttcccctac atggatagtc aaagccaaaa gaaatgtaaa agctaacatc 1739161 aacatctttt tcaaaagagt tcctcccgat atcttttact tcaatatatt ggaagggtct 1739221 tttctgatca agacagtctt ctccaaatga atctttagca ccatgaaatg agccttaata 1739281 agaacagttt taacccaaat caacctctat tcgaaataag gcttaccaat ctatattctt 1739341 tttaaaagtt tctgcatttc tttatttagc tcctagacac atataaaaaa tgctcctata 1739401 agttcaggag cactacaaaa aactgctaaa gtgttttcta tcgatttatt gtattcatta 1739461 gctcaaagaa atattcaggc ttttgagtct tatttagctt ataccatgaa cgcaatgtat 1739521 ctggtgcaaa tacatctaat tttttcaata cttctaccgc aaattccaga ggagcaattc 1739581 ctgatgcagt aaccaaattt tcatcagata ctgcaggccc cttttcatag aatgtttctc 1739641 ctttgtaatt agggcagacc atattcatat agtcgaggtc attgcttgtg tgctttctcg 1739701 aatttaagta tccttcattc gcgaggccca aggttgcccc acaaattgca gcaatagtcg 1739761 tgccgagctt taaagcgtcg ccaacttttt tcaagatcgg ctgatgaata tcttctcccc 1739821 aagtgtttcc tccgggtaaa atgataagat cttgactccc aagagtacat tcgtcaagag 1739881 aaatatctgg ttttatgctt aatcctccca acgtagttat catttcttta ttaaccccta 1739941 ctgtaactac ttttaaagat gctgcatctt gtttaaagta tctccctgag tttagttccg 1740001 caattaaata tccatattcc cagtctgaca ttgtgtgaaa tacgtagaga taaacttttc 1740061 tcgtttgcat ccaataacac tccaatcaca attgataaag ctttctaata gatgactttg 1740121 ctgacagtca ttgtcagctt ttttgttgat tctattctta tgcccttgtt ctcccaactt 1740181 ataaaaatat aagatcaatt gattctatgt ttactagcgc aaaggggttt gttacactaa 1740241 ctgtcatggg aaacatttca aaggtaatac aaaatcattt gaatgaggag gcctgatgaa 1740301 gttgaaaact aaagcgtcaa taaaattcgg aatatgtgtt gggcttttat gtttaagcat 1740361 tactggtttc acaccttttt tcaactcaac acatgccgaa gcaaaatcca tagaagacac 1740421 aaacatggca agctgtataa cgaataaaaa atttgttcaa cttgagaaaa aatttgatgc 1740481 caggcttggt gtttatgcaa ttgatatagg ttcaaacaag acaatcgcct atcggccgaa 1740541 tgaacgattt gcttacgcat caacctataa agttctagcc gcagctgctg tcctgaagaa 1740601 aaactcaatt gaaaaactta atgaagtcat ccactacagc aaggacgatc ttgttacata 1740661 ttctccaatc acagagaaac acctagatac aggcatgagc ctaaaagaaa tctcggaagc 1740721 ggctatccgt tacagcgata ataccgctgg gaacatcttg ttgcaacagc ttggcggccc 1740781 taaaggtttt gaaaagtcac tgaaacagat tggggatcat gtaacgaaag ctaaacgatt 1740841 cgagacggat ctaaactctg cgattcctgg tgatattcgt gacaccagca ccgcaaaagc 1740901 actggcaacc gatcttaaag ccttcacttt agataacact ctcacgactg acaaacgcat 1740961 gatcttaacc gattggatgc gaggcaatgc tactggtgac gaactgattc gggcaggcgc 1741021 tccaatagga tgggaagtcg gcgataaatc cggagccgga agttacggga cacgaaacga 1741081 cattgctatc gtttggccgc caaacagagc tcctattgtt gtggcaattc tgtcaaaccg 1741141 ctttacgaaa gatgctaatt atgataatgc tcttatcgct gaggctgcaa aagtcgtcct 1741201 taacgatctc aaataatatg tttagccttt tgccacaaag gaaaagacat tactttttta 1741261 acttctaccg ttcatttttt gatgaacggt tctttcataa gacctctaga atcatatatt 1741321 taaacaccac aaaattaaac attattataa ttaacagcaa gttttcattt tatggaacaa 1741381 gtaaagtttg aatctgacaa gaattaagac taagcaccct aaaatccgtt ttcttttctt 1741441 ccaagaatat actccttagt gcaagccatt ataaagatac aagtgaacat acaatgcaga 1741501 caactctctt aagtctctta ttctgtgacc aatttgtaat actcatgaat atccggactc 1741561 acttccaata tttcgtctcg ttcgaagaca ctaacatatc aaaccacttg aattaacata 1741621 actgaacttg atattggtca ctggcagttt caatgcaata gaacaacatt tgttgtctca 1741681 gaggttatct atatgagaat tcaacaattt ttttataata attcatattt ttgtatcgtt 1741741 gcacttggtg gatttgactc ttttcgtgta tggaaccaca cttttatttt ttcacctctt 1741801 ttgagatcat ctgtgttatc aatctcactt aatcctacaa ttactatgtt atttttaaac 1741861 ttgttcataa gttgtccttc agaaagattg taatcttctt ttcctggagc ttttgtatcg 1741921 gtaatgagaa ttgccctttc attgtcttta agcacgacat agcctactag gctctgcatc 1741981 tttgtttcgt ctccgttttg ttcattttta ttgcagcctg caaggaaaat aatgagcata 1742041 atgagcacta tcaagcttac tccgatttta ggcatctttc ttcctcctct ttaaactcat 1742101 ctttaaaata aacaacagga tatcacccaa cccatctact tctttttgca attcataaca 1742161 gcagcatact cattctccaa ttcctcaacc ttctttttat tctttctcaa atatttgcat 1742221 gtggtagccc tcgatattat ccgcttactc atttttgcgc tttcaaatat attattgaag 1742281 gccgcttctt tctggattcc agcataaata tacttatcct tactgtcgtt tactatcgca 1742341 acttccatta aaatcgagat ttttactttt tttatgatcc attattcact tccaaaataa 1742401 cttccaatta caacataata tatgtataaa ttgtaaatgg agttgatgta attgaagatt 1742461 aggaaaatct tattgagttc tgctttatcc tttggcatgc taatatccgc ggttcccgca 1742521 ttggctgctg gcacttcgtc tgaggttgca gtaaaaaatg aagaatatga ttatgacact 1742581 atataccgca ttagtcctct gccaatggac ttccagccaa caatagaata caacggttat 1742641 acttatacgc ttacacgtca ttattttgat tactcaatcg ggttttacac ggctatttat 1742701 acaaaagttg tttaaactta taaaggagct ttttagctcc tttttctctt gttttaagca 1742761 aggtatttct ttctatgtgg tcccctatca aatacaacat caacattctc cagttctctt 1742821 tgacacgaac aaaatctaaa gtttggtttt aaatgctggt aataaaaaat tcactttaaa 1742881 gaagtgccgc ccgcaaaata cggcttttgt acactacgcc aattttatat tgaaaagcca 1742941 gacctcctca aagaggttcc agcttttctt aatgtgctat cgatcttcgt tagttcaacg 1743001 ggaactttat cattcggtac aaatgcagcc tcccaacttc tagttagggc tgatggcgga 1743061 atatctgacg gttctctaca cacatcagac attagaagat ttcaatgtag ccttctgtac 1743121 catgaacgcg aattcgttgc ccatctttta tcagcttggc agcattttca acgccaacaa 1743181 ctgcaggtaa gccatattca cgggctataa cagctccatg ggtcatcagc cccccaactt 1743241 cggtgactag gccttttatg gatacaaaca atggtgtcca gcttggatcg gtaaaggagg 1743301 taactaatat atctccatct tctaaatccg catcttccat gtttaaaatg acacgcgctc 1743361 gcccctctat aactccggag gaaacaggta gacctacaat cgctccggct gggagatttt 1743421 ctcgtttata ctcacctgta acgatttcac catcagacgt gataacacgt ggtggagata 1743481 gtttttcata taatgtgtac tcgtcttttc gtgtactgat gatttgataa tccagtttat 1743541 gtgtgcgcac gacttcgtga agttcttcaa aagtgagata gtatatatct tctttttcat 1743601 gaataacgcc cgcttctatg agttgttcgg cttctttcag taaagcctgc ttataaacga 1743661 agtatcgatt aaccatgccg tattttggat attccctaaa cccgctgaaa ttccggatga 1743721 tatctatcgc tcgttttgtt tctttggctt tttgttcacc atccggtaat tgcttcaatc 1743781 gatctaataa ctcttgttct ttcttcaaag cttcctgtcg cccttgctca aatttccgat 1743841 ggccgacatt aggctcaaaa tttttaatat tattaagaat cattgggaca agtgtagttg 1743901 gtttttcgct ccatcgagtt cttgtgatat caatctctcc ggtacatcgc attccgtatt 1743961 tgctgagata atcatagatc gcgtctcggg ttttgcttcc gccatcaaac ttagccagtt 1744021 catccaaaaa gttatcatct tttacatgtt gtaagtaatc aattacctct ggataaggac 1744081 gaatcacatc tgcgacgtct aatagcgcaa gacccatttc tgaagtaata ttatggggta 1744141 cagattgaga aagcgtatct gctgcgtttt tttcacctaa ccactcgttc attttttcgt 1744201 taatccataa tgaagcattc atagcagttc gaattagaac cgaacttttt gggttaaata 1744261 aaatcttctt taattcctga atatcttcca gaataaaacg aaataaatct gatcctgatt 1744321 tcgtttggat gttttgtttt aactcttcta tcgatgtttg actgctctca atcaaatcag 1744381 acacgattgt cggatcgttt tcaacttgag ccggcatatc tgcattgcct ctgctgggat 1744441 ttggtgctgt tttatcattt ggtatcgact ttatgaaatc tcgtcgcttt attatggtca 1744501 taagtgcgtc ttttaagagc tgatcgtgct gccccatgcc ttttaagaaa acttctctgc 1744561 tgtcagggga tgccagatga tgtgtgacat caacaaatag ccttccaccg gctttacgca 1744621 tgggtgcaac agtcgtcaac agaaaaaaag acaatcccag tggttttatg ggatccgtca 1744681 tcatttgttg atgaccaaca gaaatataga cgtgattttc ttggtcactc gcttcaggga 1744741 tggggaataa agtagtgatt ggacgactct gtacaatata aaaagtatcg cgggccaaac 1744801 accattcgat atcttgcggc tggccgaaat gagcttcgat ctgtcttcca atgcgtgcca 1744861 gctgtaaaat ttgttcatca gtcagtgttt gagccttttg ctgatcagaa tcgatctgct 1744921 gtgtttctgt tccgccttct tttcgtccgt agatagccat ttttttagtt gctattctct 1744981 tatcgatgat ttgcccatcc tgtactttaa aacaatcggc agataccaag ccagaaacca 1745041 gtgcttcacc aagtccaaaa ccggcatcga tggataacac ctttcggttg gaggtaatcg 1745101 gatcagcggt aaataaaatc cccgaagcct gagggaaaac catcctttga acgataacgg 1745161 ataaatagac ttggctgtgg tcaaatccat tttgcatacg gtaaataacc gcgcgatccg 1745221 taaataggga cgcccagcat ttactgatat gctgcaagat tgcatcgacg ccggtaatat 1745281 ttaaataggt gtcttgttga ccggcaaaag aagcatgtgg taaatcctca gcagtcgcac 1745341 tagaacgcac ggcataggca tgttcctcgc caaactggga gagatattga gccactgctt 1745401 tcacaacatc ggaaggaatg tctacttcca taatgatttg ccgaatcttc cggctgatgt 1745461 taccaatctg atctcggtcc tcaactttta gcatggtcaa ttgatccaac aacacttgta 1745521 acgtttcgtt ttgttcgatg gctttttgat atcctactgt tgtgacacaa aatccttctg 1745581 gtacttgtat accttgaatt tttgataatt cccctaaatg taaccctttt cctccaacga 1745641 gcgaaagctg tgttttttca atttcatgta aaccgagaac caaagaactc attctacatc 1745701 tccccttcaa aaaaaaatat tgacaagagc ttcctagcag gatataataa aattataaga 1745761 tggatatcta taacttttta actagaaagc gcacgtagtg tgattatatc accgtgtctg 1745821 tttttgtgca atataaaaag aacctgggaa atttcaccag gttcttttct taatttccat 1745881 agctagtcgc attaaaaaac ttggtttgag ctgattcaat cctctaagga aatcctaaag 1745941 ttgggttctt tttgaactta cttgctttgt tcgtagagtc cccattcata aattggactt 1746001 tttgttctta acagtcccac ctttaactag tataaagtta tgaggatctg gttaactact 1746061 agatattttt attttgaata aggcttatgt ttgataaaga agggttatgt aaaggtgtct 1746121 gttgtgagca agcgctgact acaaaaaatt gatagcattc tcatttaaat accattctat 1746181 taacctatag ggaaagtttt aaaaccagat ggagaatacc ctacctccag caattccaag 1746241 gccgttcacc tagtagaaaa caacctttaa ccattactaa cgattttaat aatcattgat 1746301 tataaaactt ctcaaggaac gatcagcagc ccgttagcta cccctgatta aggatgatct 1746361 gttaccacac tgttacgtta gaacttccac tactttgata tccttctgtc gccatgactt 1746421 ggtaagccca attactgccc agattcattc catggctctt ccatgcgttc acatgattgc 1746481 tgaaagtgat tgtagcgttg cttccggttg gtctcttcga ctggcgaaca ctccagtact 1746541 gcgtaaaagt agtgcgatcg ccatcaatgg aaggtgcgtt ataacgtgta gttgtatata 1746601 tgtcatatgt acccccatca ctttttacag tacctttata cgttccagta ggtctataag 1746661 taccccatga atccactaca taatattcta tgagaggtga tctcgtccaa ccatataaag 1746721 ttaaatatcc attgccattc ggcgcccaaa ctccggcatt atagtttatc gtcctaaatg 1746781 gcgaacctgt agtccaacct ttaccaacaa caaaatttcc ggtattagac caattaacac 1746841 tgtaattccc gccagaccca ttgacagcgt ttactatacc gcccccatca gtccaatttt 1746901 gccagtagtc tgtgctagct gcagaggcgg ttgccgaaaa caagctaata ctcattaaag 1746961 ctgccgataa tccaactaag aaattctttt taaacttaaa catatgttac ctcctataat 1747021 attttttccg actttgaggt agcactcgta tacatttaaa acattcttaa ttactaacgc 1747081 caaagctttt gatcgtcccc ttcagtataa taccacgaat tcatgagcaa atattaaaag 1747141 tatttgtaat tcaattacaa atacctagaa acacattata agtggtcttc ttccaccata 1747201 tcctgatccg agctcgatgt acatgccttt acggcacaca cgaatgtggc gtgtggtgca 1747261 tcgcctcaat acgcaaagac gtttgcctta ggcaaacgtc tttttttgcg ttatccgatt 1747321 tttgtgccgt ttgggacagg ctgatccggc tgcaaaagga cgacgtcgcc ctggccgggt 1747381 atgccgccga ggaccaagac ttccgattta aatccggcga tccggcgggg cggaaagttc 1747441 acgactgcta tgacttgctt gttgatgaga ccttccggct tgtaacgctt cgtgatttgt 1747501 gcgctcgatt gttttatgcc gatttcagtc ccaaaatcta tcacaagctt gattgccggt 1747561 actcttgctt caggaaattc ttccgctttt acaattgttc ccgttctgat atccaatttc 1747621 tcaaagtcat caataactgc catatcaata actccttttt ctcctattgt aaaggagata 1747681 tacaatattc ttttaactaa agagccatca ttttttatcc gaatataagg tgtttcgata 1747741 caggcggggc ggcattcctg tgcttttcgt gaaccatctt gtaaaagaag aaaggttttg 1747801 aaagcccagc gcctcgctca cgacggtaag agtttcattt ctctccatca gcattctttt 1747861 tgcttcctca aggcgaaggt cggcaatata gttctgcggg gacttccctg tctgtttttt 1747921 gaaccagctt gaatagtaag ctgggtgata atgctcgatt tctgccagct tcttaatcgt 1747981 cagccgctca aataaatggc tgtgaatgta tgcaattgag gcatagctat gggattgaag 1748041 cttttctttt atgtattgta ctagcatatg aagcgagttg gctgttccgg cctttgcttc 1748101 ctctgtcagc aagtacctga tcgaagacca gaaaggatcg agggcagctt caattcctga 1748161 tcctgcacga tactcatcaa ttttcattgc atgaagcgga acatccagta caagacattc 1748221 atttcttccg atagaacgga agcgatgctc gcactgcggc ggaatatata aaaaatgatc 1748281 cggatttaat ttcacctggc gcccctcagt ctcaagatca atactccctt caagcggaaa 1748341 aagaaattgg ctgtacgcgt gcttatgtga atgatatagc cgtgtgtatg tccgtttttc 1748401 gcaaattatc tcttgaagcg agtccattag caaacccctt cctttggtca tcttttaatc 1748461 cggtaatggt gttccgatat aggcgaaaag ccgatttttc catataaaga aactgccgcc 1748521 agattttctt tcatcacttg taaaaacatg cgttccgctc cgttgttttt tgcccattca 1748581 gtcaacaccc tgatcacttg ggttcctgcc ccttttcctc tgtgctcctc agctacaacg 1748641 atattactaa gtccgccata accatcaatg acagaaaccg tgccaagcgc tgtcaggctt 1748701 tctttgtcat acatcttgaa aaaagtttta cacggcggca tgcgttcgaa tatgtgtttg 1748761 taacctttgt gacgctcggg tgaaaaccct tctaattgaa taaattcatc tatccaaaca 1748821 gatgatggct cttgttccca cttgtatgta aatcggctgt tgtcatttgt tcggctcata 1748881 attgaccggc acaacgctgt catctggaag cactcgtcta ccttttcata acggctgtct 1748941 gccaatgcgt catcaagccc tttcggtgat gcgttgctaa tatgaaaaca aacaggtaag 1749001 cctaaacttt gataaaaaag ttcggcctct agctgaaaat ccccttcagg catatccgca 1749061 gacgtccata cgctatttgc ccttttggtt acgccaaaat tcgctctgag aagccatttc 1749121 cctatgcttt tttgaaaata agccggccat gaagctgccg ctaatcgttc aatcttgcga 1749181 atgtcatcca ttgcataatg cctctcccct atgtatactc ccttgatatt atacaatatt 1749241 cagaaatata agacatccat ttatttgttt acataatatt tttattgttt attaataatc 1749301 ctgacaaaaa tgtccgaatt gaaaatgaca ggctttctaa aatgtcctcc tcacgttcaa 1749361 atgcttcttt tgcgattaaa acagtaaagc catgcagcag acttctgagc ccccttgtcg 1749421 catgaatggc agtcttttca cttgcatagc cgttttcaat gagcagcttc gtcacaagac 1749481 agacaatttg gtcagagacg atttccgtcc gtttgtcgtg aaccttaaga agagccgctt 1749541 cataatatcc gggattttca attgcaaaat caacatatgc atgagctaaa gaaagcatcg 1749601 cggaatctcc ctttcgttcg gttacggagt ccgccatttg atcaaaaagc tttgtcagtc 1749661 ctctgacagc aagttctgct ctgatcgctt gcagcccgtt gatatggtta tacaatgacg 1749721 gggggcgaac attcattttt ttagaaagtg cagcaagtga gacaccattt accccttcct 1749781 gatcggcaat ctctgctgca gcgtctacaa tcattttttg ggtcaaacct attctcggtg 1749841 acatgctcat catcctttct ttgctttttg gatcgcctgt ctcatccgct ctgaaggtga 1749901 tcgcaggaat tttccatgtc cgacagcgag acaggaaggc gccttatcgg cgagcaattg 1749961 tgcacttttg atggcctcct ccttattcca tgtggcgaaa gcgggaaaag gaaacgccca 1750021 ttttatctga cctgatacag cgattcctcc gcgcaactga aacgcatctc ctgctattaa 1750081 agtgccgttt cttgtatcaa gaaatgacat gctgcccggt gtatggcccg gtgttggaat 1750141 ggcaagcaga gaaccaattg tttcaccgcc cgtcagcagt tggtgaggct ttgtttgtat 1750201 gtgtttcgga atacctcctt ttataggcgt ctgcggctca tcttgccgca aagatgtgtc 1750261 accttggagc aagaatgaat cccgttccga gatcatgacc tttgcatgcg gaaatgtttg 1750321 tgccaatgta tccagtgatc cgacatggtc cccatgtgca tgagtcagta aaatatgctg 1750381 aagcggtttt ccaagctgat tcacagcttg aataatccct ttatagctgc ctggcagtgc 1750441 ggcatcaata agggtgactt cgttttcttc ctctactaaa tagcaattaa ccggaaacaa 1750501 tgctggaaaa aaagtcagct gccaaaccgt ttggtactga gtaattctca tctttttatt 1750561 cctcctaaca aaaactaatg gtgttagttt tattattaac taacaccatt agtttttcaa 1750621 gagtttatta tttttttatc gctacataaa tgttaacttg tgctcgctgt ggcactgcgg 1750681 cattttgatc atacatctca aagtcacctg taaacgtgcg cagatgccgc ttatcccaag 1750741 tccaaatttc cttccacgtt tcaagcacaa tctcttcaat aggaccgatt ctggaagtga 1750801 aaacggcgta agcggaagcc ggcaaatcaa tattttcata tggtcccgga agaatgtcgt 1750861 cgtattcctg aaacgttccg actgaaaacg tataaaaccc attcgtctct tgttcataat 1750921 tcgaatataa ggcaataatg ctcttgtctt tttcagcctg tgataaaaga gcgctcatat 1750981 cctgcttcca taattgatcc cacagtgccg gaatcctcct ttcttccgtc atttccagtg 1751041 cgttgcttgt ccgttgtgat agtccggcaa atcgtttcag gtctaagtgt gttatatgtg 1751101 aaaagcccat acgatctcct ccttttttta agattataga caaagaaacc tgacagcagt 1751161 gtgtcaggtt tcatatattt tttgcatgtg atgaatggtt tcttttactt tatcccttat 1751221 atgaagaggc tgcagaacct caatatcctt tccgaactgg agcaaaaaac cgatcagcca 1751281 ttgatcttct ggaagtgaaa tcaccgcctg gcagatttca tcttcctcac aacagtgaag 1751341 gacatcatat ccgaaccatt cacctatacg ctgacgtgct gacggctgaa caagaataac 1751401 caattcagtt aaacggtcct tttggtacca actcttatcc catggcaaag tgtccagctg 1751461 aatgtctttt ctgataaatg tctgatgtaa gatggccaga tctttcatcc ggttcagttt 1751521 aaaaaagcga aaatcatttc ttaccaggca gtaggcatat aaataccagt gccccgcctt 1751581 gcaaaccaat gtataaggtt cagtttcccg aagtagtgtt tccccgcttg cgcttgtata 1751641 tgtaaaagat atcgttaaca accgatcgat ggcagcgctg attttctcgc gcagcgtctt 1751701 ttgatcctca gtatggcccc aagccgtcat gtcaataaac catttttctg tttggtgctt 1751761 aaatgcttga gtagattgct caggtataag gtgtttgatt ttttgatagg ctgtgctgtg 1751821 agaaacgggt tcatacatag atgaaacgct ttgcaaagcg gaagcaattg caaacaattc 1751881 ctcctccttc agccactctc tttcaagccg atacgtttcc atgatgccaa ttccgccccc 1751941 ggaaccctgt gaggtcacaa tcggaatacc agccctattg atcgtctcaa tatcacggta 1752001 aattgttctg acagatactt caaacagctc agcaagctct gcagcctgca cttgtttttt 1752061 gctgatcaat aacacaacca tcgctaacaa acgttccagt ttcattctgc gcaccttttc 1752121 ttcttgtatt ttccaacaaa acaatcataa cattttgata aagcttgggc atatctatta 1752181 tgcggcggaa tacacctcgc atatgctatg aaaacagggg tttccccttc ttttttgtgt 1752241 tcagtattta tttcagctac tatttccgac cggataagca tacacttctc aacggagggg 1752301 atttcacatc atgcatctta cacttcagag cgtttatcct gccataatca tcatcttttt 1752361 tctgtataaa aaaattaaaa ggtccatcgg ataccagccg ctgaagcccc gctggctgtt 1752421 cacccgtatc attcttttct cgctgtttgc ttttggactt tcaatcttca gcgccattca 1752481 ccctttttta tatggatatc tcattttggg cattcttggc ggatggctcc ttgtcttttt 1752541 cgctaagaaa aacatctctt ttgaaaaacg cagaggaaag atctattttc ggactcatat 1752601 ttgggtagag gtgattctct taactttatt tctatcaaga tttctgtatc gagtgacgga 1752661 gctttatctt acctcacctg atctaaaccg ccttggatca tacagtcagt caatcggaac 1752721 ggaccctctg acaattggcg tctgttttct gatagccgtt tattatatcg gtttttcttc 1752781 ttttatcatc aagctcagca gaaacgaact tgaacagcac gaatacaata aagaaaaaga 1752841 catccttgcc cgctaacagc gagttaagca aggatgtctt tttcaatcat gctgtgtatg 1752901 atggatcatt tgctgaagaa catctaaaac atgttcatcc tccggagagt aataaatcga 1752961 tgttccttct ctgcgcgatt tgacaagccg gagatttttt aaaaatctaa gctggtggga 1753021 cacagtggat tgcagtaaat tcagcttttc tgcaattccg tttactgcat gctcaccttg 1753081 ggacaataaa tggagaattc tgattcgggt aggatctgaa agcgctttga atgtttgcgc 1753141 gactagaaac agcgtctcct cgtccagatc agcagccgat tgttccgttt ctctaaattc 1753201 agtcatatgt atcacctttc tttattcata gttttatctt ataacaaatg cgcttgagtg 1753261 caaaccagcc tgcttgtatt ccatttcaat ctcatagttt aaatttatgt ttcaaatcag 1753321 gtttttactt ggtctgatat accctcttat gtcataataa aaaaggtcat actgctccaa 1753381 acattgaggg tgaaacacag tgaagaaaaa gagaaaaggc tgtttcgctg ctgcgggttt 1753441 tatgatgatt tttgtctttg tcatcgcctc ttttttattg gtcctgcttt ttttcaaccg 1753501 ggatttaatc aaaaaacttc cgatcgatac gaaaacgatt gttttggaac gtttaaccga 1753561 ttacaaaccc ttggtggaag aagagcttga aagccaagga ctctctaatt atacatcact 1753621 catattaggc atgatgtatc aggagtcaaa aggaaaaggc aatgatccca tgcagtcctc 1753681 tgaatctctg gggttaaaac gcaatgagat aacagaccct caactcagtg ttaaacaagg 1753741 catcaagcaa tttaccctca tgtacaagac cggtaaggaa aaaggcgtgg atttggatac 1753801 cattattcaa agctacaaca tgggggcagg ttacattgat tttgtagctg aacatggagg 1753861 aacgcatact gaggaattgg caaaacaata ctccgagcag caagtcaaaa aaaatcctga 1753921 tctgtatact tgcgggggaa atgcgaaaaa tttccgctat ccgtattgct acggtgatta 1753981 tacgtatgca gaaaaagtaa aagaaaaaac aaaaactgtt gaagaatctt tgcaggttgc 1754041 aacacttgaa accatggaat ccaaggctca tgaataagag tctatcaatt tactgacaaa 1754101 agcccaaaaa tgaatttggg cttttgccat gtttacacgt aaaaaaagcc atactgagta 1754161 tggcttttaa taatacggtg aaatcatcaa atatacaata acgcctgtaa ggcttacata 1754221 cagccataga ggcattgtcc atctcgcaat ttttttatgg cgctccacct gcatgctgaa 1754281 gcctctgatc agcgtaaaca gcgcaagcgg cacaataatt gcagaaaggc agatatgtgt 1754341 aattaaaata aagaaataaa tcgggcgcat aataccttct ccgccataga gcgtgttttc 1754401 cgcaatcgag tggtacgtca catagcaaat caaaaatagt aatgttgttg tgaacgcagc 1754461 caaaataaag cgtttgtgag ctttgatatt tttctgttta atcataatca gcgcggccaa 1754521 taagaagata aacgtaaagc tattgaatat cgcattcagc attggcaaaa tgtgaatatt 1754581 cgcatggctg aactgatcta atttaggcat aaaaaacagc actgcgatta aaccgttaat 1754641 cagaactgtc agcgtaagga caatccccgt gtaatttttc ggtttatttt ctgtttggtt 1754701 catttggtga cctctcctaa tttgtactgg ctatccaaat cgtatgcaaa ttcaaagaag 1754761 atgtcaacgg tttcgattgc ttcgtcagaa attagacaca cttcaaaggc cggaggctat 1754821 tagccccggc ctgttaggtt tacgcctctt ttatcaaatg ttcaatgacc ttatgttcat 1754881 tttcattcag caggttcttt tgaattttcg aatgaatggg tttattcata tgctgatcca 1754941 agatatcggc cgtttcttta tccccggcaa taaccattcg ttcccatctt ttcgcggcag 1755001 ctttttgatc aaggctggca gccagccgct tatacagtct cgattggttc tctgttacat 1755061 gttccctcat ccggttctct tcaaatggtg gcgctttgtc tacagcggaa tggctattct 1755121 tccaagactc attgatcata tcatactcat aacgctccac cgcctcaatt tttcctaaaa 1755181 cagtttcaat aattttcact tcatgctgct gagttaaaat aaacgccgta cttgggtatg 1755241 tctggcgcaa accctttagc tgatccagga cagctgtttc ttcccagtaa aatcttgtat 1755301 ctacagggac ttgaagctta ataggttccc atatgccgct gtcggaaaca aaaaacacga 1755361 gactgcgggg catgtctttt cccattgcat tcaagtattg attcatttta gccctgattc 1755421 catccagaca cttttcctcc tctggatcac tagctgccaa atactctttt aatcggctga 1755481 atcctgactt tagggcaatc ttccattctc ccccctgctg ctctggatct ctcatgtctg 1755541 tattgagata cagagagaga attttatccg gcggttccaa ttggacatac tgtaatttgt 1755601 taatcaatga atcaatcgcc attccgattc ctcctttttc acaggttagt tttctttttc 1755661 ctctcttaaa aacgatcaaa cctgactttc cgctaatttc tagtaataat ggaattgttg 1755721 tttacaatac gcctctcttc taatacaatt ggtaactgtg tttctaagct gttttttgaa 1755781 aggagtttga tcttgtttac tgttaaagaa aaaaatcgtc aagagcttga ggaagaacta 1755841 aatgatttag aatttcaaat ttatcgcatg caggagaata tgaaggattt atctaaagat 1755901 gccaaagtgc ttggtattga tcaatcgaaa catgatgagt ggatgattgt ttcctcgatt 1755961 gatgatggcc aaacatgcaa aattatgcta actgattgta aaacggcata ccgaggaaaa 1756021 ggctgttttt cacttgtagc gtcttacaag gacgatgcca ttcatatagg ggatataaaa 1756081 ggccctccga atcacgggtt tggctccatt tgcatgaaat atttaaaaga tattgcaaga 1756141 gaccataata taccgaaagt caccggagac atcgccaaac gggattggaa tcatgtagac 1756201 cggctgattc acttttatga aaaacatcac ttcaaagtat gtatcgatca tgatacccaa 1756261 tccggcagca ttaagtgggt tgatttgtaa aaaagtctgg aagaaagagc caagatatgc 1756321 tgtaatggta taaaaccatt gatggagggt tctatgtacg cctcaaaact gaaaaaggga 1756381 gacgaaatcc ggatcgtgtc tcccgcgacc agcatgtcta tattatcaaa tgaagcaaaa 1756441 atccaagcaa aaacggcgtt agaacgctta ggttatcggg taaccatcgc tgaacacgca 1756501 aatgaatgta acgaatttga ttcatcctct atcgagtcaa gagtccatga tctgcacgct 1756561 gccttttttg atccaggcgt caaagcgatt ttaacgacac tcggagggtt taattcaaat 1756621 cagctgctgc gttatcttga ttacgagaaa atcaaacgac atccaaaaat tctgtgcggt 1756681 tattccgata taaccgctct ttgcaacgct atttatcaaa aaacgggtct tgttacgtat 1756741 tcaggtcccc acttctcaac atttgcaatg aaaaaaggac tcgattatac agaggagtat 1756801 tttctttctt gctgcgcttc agacgatccg tttgaaattc acccctcaag tgagtggagc 1756861 gatgatcgct ggtttttgga tcaagaaaac aggcgttttt atcctaataa cggccctgtt 1756921 gtaatccaag aaggttatgc ggaaggtact ttaattggcg gaaacttatg cacgcttaat 1756981 ttgctgcagg gaacggagta ttttcccgaa acagaacata ctattttatt gattgaagat 1757041 gattatatgt cagacatcca tatgtttgac cgcgatctgc aatcactcat ccacctcccc 1757101 gctttttcac atgtaaaggc gattttgatc ggcagatttc agaaagcatc aaacgtatca 1757161 atagatcttg taaaagccat gatcgaaaca aaaaaagaat tatccggcat cccgatcatc 1757221 gcaaatataa atgccggaca tacctcgcca attgccacgt tccctatagg aggaacatgc 1757281 aggattgaag ctatttcggg tacatcacga atatggattg ataaacatta atcagcttgt 1757341 aaattttttt acaagctttt ttagcgcaat cggctatgca tgccgcacga gacatgacaa 1757401 atgtcatata ggaggcatga tgtgtgctac tacaaaagac ttctctcatt agcgtatact 1757461 gaaccgagac acacaatgag aggatactta ctatgactga acaaaccatt gcacataaac 1757521 aaaaacagct gacaaagcaa gtcgctgcat ttgctcagcc tgaaacaaaa aacagcctga 1757581 ttcagctttt aaacacgttt atcccattct tcggcctatg gtttcttgct tatctcagcc 1757641 tcgatgtctc ctatcttctt acgttagcat taacggtgat tgccgcaggt tttctgacaa 1757701 gaatttttat catcttccat gactgctgcc atcaatcttt tttcaaacaa aaacgctata 1757761 accacattct cggttttctg acaggtgtcc tgactttatt cccgtatctt caatggcagc 1757821 acagccattc gattcatcat gcaactagca gcaatctgga taaacgcgga acaggagaca 1757881 tctggatgtt aacagtaaac gaatataaag ctgcatccag acgaacaaag cttgcataca 1757941 gactttatag aaacccgttt atcatgttta ttctcggacc gatttatgtt tttctgatca 1758001 cgaaccgttt taacaaaaaa ggcgcaagac gcaaggaacg tgtaaacaca taccttacga 1758061 atctggcaat tgtcgcgttg gctgccgctt gctgtctgat ctttggctgg caatcgtttt 1758121 tactggtgca aggcccgata tttctgattt caggttcaat cggtgtttgg ctgttttatg 1758181 tgcagcatac ctttgaagat tcttattttg aagcggatga aaactggagc tacgttcagg 1758241 ctgctgttga aggcagctca ttttataaac tcccgaaact gcttcaatgg ctaacaggca 1758301 atattggtta ccaccacgtt catcatttga gtccaaaggt gcctaactat aagcttgaag 1758361 ttgctcatga acatcacgaa ccattaaaaa acgtaccgac aatcacctta aaaacaagcc 1758421 tgcaatcact tgcgttccgt ctatgggatg aagataacaa acagtttgtg tcatttcggg 1758481 ctataaaaca tatacctgta agccttccgc ctgattcacc agaaaaacag aagctgcgga 1758541 agaatgcctg atgataaagg aggtcttcta atatactaga aggcttcctt tttattgttg 1758601 gagggtgcat tctggctttc acaatgataa agttacaagt aagatgaaaa gctgaaaatg 1758661 aggtaagatc atgattaaaa atcattttac atttcaaaaa ctaaacggga ttacgcccta 1758721 tatatggacg atatttttca tcctcccctt ctactttata tggaaatcat catctacatt 1758781 tgttattatt gtcggcatca ttttgacgct tttatttttt tcggtatatc gatttgcttt 1758841 tgtctcaaaa ggctggacca tttatttgtg gggattttta ttaattggca tttcaaccgc 1758901 ctccattact ctgttcagtt atatttattt tgctttcttt attgcttatt ttattggaaa 1758961 cattaaggaa cgcgtccctt ttcatatttt atattatgtc catttaataa gcgcggccgt 1759021 cgcagccaat ttcagtctcg tattaaaaaa ggaattcttt ctgacacaaa ttccttttgt 1759081 cgttattacc ctcatcagcg caattttatt gcccttcagt ataaaaagcc gcaaggagcg 1759141 cgaacgactt gaagaaaagc tcgaggatgc aaatgaacgg attgcagaac tggtaaaatt 1759201 agaagaacgt cagcgaattg cccgcgatct ccatgatacg cttgggcaaa agctttctct 1759261 tattggttta aaaagcgact tagcaagaaa attgatatac aaagatcccg aacaagcagc 1759321 tcgtgaactg aaaagtgttc agcaaacagc gcgaacttct ttaaatgaag taagaaaaat 1759381 cgtttcctct atgaagggca tccggctcaa ggatgaattg atcaacatca aacaaattct 1759441 cgaagcagct gacattatgt ttatctatga agaagagaaa tggcccgaga atatctcatt 1759501 gctgaatgaa aacattttga gcatgtgctt aaaggaagct gtcacaaatg tcgtcaaaca 1759561 cagccaggct aaaacttgcc gagttgacat tcagcagctc tggaaggaag ttgtgattac 1759621 agtgtctgac gatggaacat tcaaaggaga agaaaattcc ttttcaaaag gacatggctt 1759681 actcgggatg agagaacggc ttgagtttgc aaacggaagc cttcacatcg ataccgaaaa 1759741 cgggaccaag cttaccatgg caattcctaa taattcaaaa taaacataaa ggatggctta 1759801 tatgattagt atatttattg cagaagatca gcaaatgctg ctgggcgctt taggatcact 1759861 tctaaacctc gaagacgata tggaagtcgt aggcaaaggt acaaccggcc aagatgctgt 1759921 tgattttgtc aaaaaacgcc agcctgatgt atgtattatg gacattgaaa tgcccggaaa 1759981 aacagggctt gaagctgctg aggagctaaa agatacaggc tgcaaaatta tcatcttaac 1760041 caccttcgcc agacccggtt actttcagag agctattaaa gctggcgtta aaggctattt 1760101 gttaaaagac agtccgagtg aagagctggc caacgccatc cgtagcgtca tgaacggaaa 1760161 acgcatctat gcacctgaac tgatggagga cttatacagc gaagctaacc ctcttacaga 1760221 tagagaaaaa gaagtgctcg aacttgtggc tgacggtaaa aacacaaaag aaatcgctca 1760281 ggaactcagc atcaaaagcg ggacggtgcg gaattatatc tcaatgattc tagaaaagct 1760341 tgaagtgaaa aatcgaattg aagccattac ccggtcaaaa gaaaaaggct ggtttaaata 1760401 aaaaaggatc ttggcatctg ccaggatcct ttttgttaac ctgaaattcc cgtttgagaa 1760461 cctcgtcgca accagaatta aattgatcca tatcctcgct cctacgcccg ctgaacgatt 1760521 gtttggttaa cagcccaata aaagactgga ttgaatgata tccctgttaa aatggtcggc 1760581 cattgcacat cagcagaatt tctgatattg attatattgt attttcagta tgacaaagtt 1760641 gtgccacttc gctcccgaag ctgccatgcc caactgcaag agcctaatat cacaataaaa 1760701 aaccgtctga aatcaatccg attccgtaaa tggtatctgc tacatccaac tgcttattat 1760761 ctgccaaaaa caccagctcg tttcgctgat caaagatagt aacaaccagc tataaatgtc 1760821 atgatgccga atgtctctgt aatgtggaat caatctttta acccgagagc ccctgaatcg 1760881 cacataaaga aaaacgggac cactttcttt tatcagcata tgatataaac agctctaagc 1760941 agaacaaaaa aagacacaag ccaaaagctt atgtctttta tcacaatcta tattattagt 1761001 ttaagacttt aacacttaca gttttgacgc cccaattaga agcatcactt ttacttggta 1761061 caaatacgtc gattttattt cctttaatag cgccgccagt gtctgctgct gttgcttccc 1761121 cgtagccttc aacatagact ttagaaccta gcggaattac attaggatca accgcaataa 1761181 ctttcgcgtt cgggttctta tttaagtcaa tgcctgtagc tgtaacgccg gaaatgccgc 1761241 cgtcgttagc agtgtaagca gtagcagtaa ctgttagttc ttttgaagct tcttgattat 1761301 ttgtatttga ttgaacagcc ttctcctctg tgttaacaga agtttctgcc tcagcctttg 1761361 tttcttgttt aggttgctgt tgtacagctt cttgtttagg ttgctctttt tgcacagcct 1761421 cttgttttgg cgcagcttga ggtgcgtttg tttgcgcatt ctcagtagct gtgtttgctg 1761481 ctgttgcctg accttttact gaaagagttg atccagcata gatcatgtca gagcttaagt 1761541 tattccaaac tttcaggttg ttgactgtcg tgccgaattt ttgagcaatc ttagaaagcg 1761601 tatctcccgc tttaattgta tattgcccag tcgtggttgt ttcttctgaa gaaatggtca 1761661 gtttttctcc tgcaatgatt ttatcagaag ttaacttgtt ccattctttt aagtccttta 1761721 ggttcactcc atttttctga gagattcccc agagcgtatc acccttttgc accgtaattt 1761781 cttttgcaga agcgtgagct ccgaatgcag ttgttgaaag tgcagcaact gccacaaagg 1761841 acataatcgt cttcttcata agtaaatcct cccttgttag ctttttattg gcggctaaca 1761901 ggtgatatcg taacacacgt aaatgtcaaa tcaataacaa aaagatatga tttagattac 1761961 agttccttta catgaaggat ttctctctga tggaaagact tgctgaaccc ttgatataat 1762021 aggcttcgca ggtcttttta ttttgaggcg aaacagagaa aataaaatgt gttttttata 1762081 gaaaaaaaga ttgtttttct gtttttttag tctgtcatcc ttgcataagc ctgtatttct 1762141 tgtaaaaaaa gccggccgta ttttgctctt ttttgttctc cgactccttt tatagacaaa 1762201 agttcatcat catttacggg ctgttttcct gacatttctt ttaacgtttg gtcagagaaa 1762261 acaacaaatg gcggaacacc ctgctcagcc gcaatttctt tccgaaccat gcgcaatcgt 1762321 tcaaatagct cgtcattttc agtaatcgct gccgctttta acgcttcttt tctcgctact 1762381 gataattctc ctttcagcac attccttcct ttactgctga caaaaagagt cggaaacgtt 1762441 ccgtctgaca tcctgatgaa gtcgtcagaa ataagaaatt cgataaaatc actgatttcg 1762501 ccaacggatt ggtgttttaa tatcccgtat gttgaaaggt cggaaaagcc gttttcaaga 1762561 acttttttat ttttggagcc ggcaagcacc tgggcaacca tcgtcttgcc aaaccgttct 1762621 ttcatgcgaa tgatacaaga taagaccatt tgcgcctccc gcgtcacgtc atgggccgct 1762681 cttgtatcgg tacagtttcc gcactgtccg cacgcatcag gctccttttc tccgaaatac 1762741 ataaggataa aacgctgcag acaatcttcc gtatgacagt agtcgaccat ttgtctcagc 1762801 ttttttaaat cctgcttttg tttctcttca tgttctgatt gctcaattaa gaagcgctgc 1762861 accataatat cctgcggtga aaacaggaga acacattcac tggcaagacc gtcccgtcca 1762921 gctcgtcctg cctcttgata atagctttcc atatctttcg ggatttgtgc atgcagaaca 1762981 aatctgatat ttgatttatc aatacccatt ccaaaagcag aggttgccac catcacttga 1763041 agctcatcat taagaaatct ttcctgctgc tcttttctca catcatcagc caaacctcca 1763101 tgataccggc ctgccctgac ctgatttcgt ttcaatctct catatatccg atcagcttct 1763161 tttctggtcg ctgtatagac aattcctgct tcatgcctgt tgttttgcac atattcgtct 1763221 ataaaccgat ctttattttc tccttttact actttaaagg ttaaattctc tcgggaaaat 1763281 ccggtatata ccgtgttttc tttttgaata tgcagctgtt tgcaaatatc atcatgaacc 1763341 tcgggtgtgg ctgttgctgt taacgccatg atgacaggct tgtcgtgtaa ttcacggaac 1763401 aagatttcaa tattcctgta gcttggcctg aaatcatggc cccattgaga aatacaatgc 1763461 gcctcgtcta ttgcgaccaa aggaacatct atgccctgca aaatccggat aaactctatg 1763521 gacgttagtc gctctggtgt aatgtaaaaa agcttataag ccccttcttt gagtccgttc 1763581 agcctctcat atatttcctg attggattgt gtgctgttaa tgtaggcggc gttaatcccc 1763641 gcttcttcta acgcatcaac ttgatccttc atcaaggaaa tcaacggtga aatgacgatc 1763701 gtcgtccctt caaacattaa tgccggaatc tgatagcaaa tcgatttgcc gcctcccgtc 1763761 ggcataatgc aggccgtatt ttgcctcgct tccgtcacca agcggatcgc ttcatcttgg 1763821 ccgctccgaa acttctcata accaaaataa tgagccagaa gggattgggc tctatgtaac 1763881 ataacgtgta aacctcgctt ttccttgaat ttctcccatc atatcataaa aaagcggcct 1763941 tcatttcttt cacacaaaaa tggaatattc actataccaa acctttttag ataaaataaa 1764001 aagccatttc cgaaaaggaa atggctttcg ctacgtcttg ccgtatgcaa gtaagaaagt 1764061 tttaaaccac cactcctcaa agtgggtgtt tgcagaaacg ttcctgtcgt cctctgcaat 1764121 ggaggcatga cattccggct tcgatataaa actccctatt acagcttaaa ggttaaaact 1764181 taattaacaa tacgcacaaa gtagcttctt taatatagta caccatcagg cgcttttaat 1764241 caagaggtca gaacaattgt ttagaaaaac tttttccagt gaataaaact gttttttctc 1764301 caaaatacct gacaattcga caaacaaaaa atatattaca ataaaaaaaa tagcctttat 1764361 tgctaaaagc gaatgattat tttcttctat attaatgtgt atatacaaaa agactcctat 1764421 ttgtaacgat aggagtcttg gctttattag aattttgcag caagatcttt tgcttcttgt 1764481 aaaccttttt caacgatttc ttgcgcttga tcaggtgctg cgttatgtcc ttcgatgaca 1764541 actgtgtgca agtcttgaac accccagaaa ccaagaactg ttttcatgaa gtttaatgac 1764601 atttcaagtg cagccattgg tccttctgag tagacaccgc cgcgagcgtt aagaagcgca 1764661 acttttttgc cgcccattaa accgactggt ccttcttgtg tgtatttgaa tgtaacgcct 1764721 gcgcgagaca gataatcaac ataagtatga agcactgctg gcactgtgaa gttccaaagc 1764781 gggaatgcga aaacaacttt gtcagctttt acaaactggt tcagatattt gtcagcaatt 1764841 gctgcttgtt ttttctcatc ttctgtcatt tccattcctt gacctgcttt aaatgttccg 1764901 ttaatcatat ctctgccaag gtaaggaagg ttttccttat gaagatctaa ttcaaccact 1764961 tcatcattag ggttgttttc tttataagca gctaagaaag cttcgtaaag tttagttgaa 1765021 acgccttctt cagctgtacg gtcgcttgat tttacaaata aaactgtaga catttgtatt 1765081 cctcccggta aactttttat atttacttac aaatagtatg ttactttctt ttttacgtaa 1765141 agtcaatcac tttattttga atatgagatt ttttttcaaa aaaaagcaag tacatctaat 1765201 atcggtgtac ttgcttggca tttttacttc gaatcttgtt cacgatccaa gatttcatac 1765261 gtctgcgagc ttttttgatc aattgtttct ttgttggata agtcttttac ctgttcatga 1765321 aactctcttt cataagaagg agcatctgtc tccagatcat cctccacatc agcttgggcc 1765381 tcaactgtca ttcttgcata aggaacagct tcaagtcttt cgtaaggaat ctcttggccg 1765441 gttttttcac acacgccata agttccgtct ttcatctttt gtaatgcacg gttgacctcc 1765501 tctaacagct cccggtcaat ctctttcact gtttggtctg tcatccggtc tgtgacgagc 1765561 gtcccgtggt ctgccatatg gttgtcaacc ccattggaaa gctcccccac ttcttccgtc 1765621 attgattctg tttccttttt ctcgccagac aattcttttt gcatatcgag caatttatga 1765681 tagagatgct gtgtttgttc ttttgtcagt gccatgtata tcctctcctt tctatcctgt 1765741 ttcccgtttt gccttctgtc aaacatggaa acatcgatgg aaagatgagc tactgccttt 1765801 ttgaacggat cgtgaccgct ggcgtcgatg gtgcttcggg ttttcgttgg cactttttgt 1765861 ccttctcttc tggcggtata taataggttg cgcctatatt taatctgccg ctcagttcat 1765921 caatggtcag ctcgccgaat tcaagatgat agtcaacttt ttcgacattc agcgtttcaa 1765981 tatgtatata ggtttcttca gactcttgtt tgctgctttg tttttgtttc tcaatcactg 1766041 agagtctttc ttcacattca cgcagtttgt caagttctgg tttcaagcaa tgcctgatca 1766101 gcgaccggaa catttttttc atgacatcac gaccctttgc atactcctct ttcgtctaca 1766161 tatataatga ggtatatccc atagaaagga gaggttttca tgcttccgac taacatcaat 1766221 atttctcatc tcaagactaa ctcgataggc accggctcat cccttacctt tggttctgcg 1766281 gagttaagga acaggtgctc tgctatcaaa agaaataacg gttttgggga acaaaatgca 1766341 gatggtattg ttatggtcat tccgattgaa tcaattgatg accgtgatgt gtcagatgca 1766401 ctcagtatga aaatcaatca tcaataacaa tggttttcgc ttgaccttcg tctttttgaa 1766461 tagtgatgta taggattccg tctttaaaaa tggcattcat ctttccatga agatgatcgg 1766521 aaagcggaat tttcttttca aaacttccgt atttcccttc tttttggcga aagtcctgtt 1766581 cattaaaata ggaaaagcgc tgccccttca ccactaaata atctccgtac gataatatgt 1766641 gaacgtcttg tttacggtag cctggaagat aaattaaaaa ctgcacttcc gcaacggtat 1766701 ctacaatatc catgctcgga aatgaagcat ctcctttccc tcgctgatct tgctgcgcaa 1766761 acggaaacgg agattggcca tttgtcataa aaggggtttt ttggtcttca tcaaatacct 1766821 gtttccaaaa gtcaccgccg tacatctgct gtgcgaattc catccactgc ttcatctttt 1766881 cgaaatccat ttgaagcccc ctgtcttaac atactttata accgccagca tacaactata 1766941 gaaaggaggt ttgcctgtgg ttcaaccaac tccgtatatc aatattaata ttttcatgct 1767001 gaaaattaat tcctttgaaa atgcttcagc ggttaacgta ggacaaaatt tattggcaga 1767061 atggcaaaat tcagataaaa aaaatcaagg ctacggacag aattttggag atgcgagcgg 1767121 atttatgggc acgagaagcc atgtggatga cagagaccaa attgattctc cggcctcttt 1767181 tgaaagtgaa gcggttaact cctcaatcaa aaggaagtga tgagatgttc ttttcaccct 1767241 ccgtcgtaaa tgtcggcgga tttaaaatca atacgatgga tcgaggttcc tctttaacac 1767301 tcggtccgta tcagcaggtc gattactttt tatcagctaa aataaatcaa gggtttggag 1767361 aagaaaatgg cgactttact cctcttgtcg tgccgatttc aaatgtatta gatgcagatc 1767421 ttgttgattc gaactcagcg aaaaacagtg tggtgtaata agaacagggc gcacatgccc 1767481 tgttcttgtt tttatatata aaaaaagcct aaccattttt tgaacggctg gctcatcaaa 1767541 tattcagctg cacaaatgct ttgtcagcac cgcctgaacc tcgcttaaat cggtgtcttt 1767601 cgcaaattct aattcgaaag ttttgcttct tgtcatcaat aaaagcccag tgtccggatc 1767661 aaacattccc gcttcttgga tggcaaagct ttcaattgtt ttatatggaa gaaatacacg 1767721 aaccttcttt ttagaaaaca ttttattgtc aaagaaaatg atccgcttat ttgtaaagca 1767781 aatttggtcc actcggagct tataaatcga ttcaattctt tccccttcaa cgagcaaagc 1767841 ctcaagcttc tttgcgtccg ttgatctgct aacagaaaaa atacccaatg aagaacccct 1767901 ctttctgcat ttatctattt gttttatcat tcactacata aaaataagtc ctttatccct 1767961 atataagaat acgacataga agacatttaa accattacga acagattaca tttttcaaat 1768021 ttttgatttg ttttttggct tttaagctgt tgtcatcaag taatacgcac atatagagaa 1768081 aaaagtttca atattcagca atgtttttat aaaaaagtgg tttttaatga tttttttaat 1768141 tttgttttat atttcctgtt ttaaccacaa aaaaaccgca gctgagctgc ggttttatgt 1768201 atcgactgct tttaacaaaa tctgtttgat gcttcaagga agcattacat ctcttcgaag 1768261 tattctttat aatagccgcc gactttattc gtattgtcga ccacaaagag aaactcctct 1768321 gtttcatttt ttacttcata ttcttttccc ggcgttaaaa cgcggtttac gatatatttt 1768381 tttgcgtttg tctgcacaca ctttactttt ttaatggttt ctttttcaag ccaattttta 1768441 tgaatcatga tgaaatctcc ttttcttatc tataagctta ttgtagcttt tttcttttgt 1768501 aaattgcaat atcggttatt cattgatttt gccttgattt ctattataga atgtttgtat 1768561 acgcttacgt ttgaagcaac tatcacagct tatttctgct attcaatcca ggaatcaatg 1768621 tgctatcacc aagaatctca gaacagacca taaaaaatga ctggaggttt gttacggatg 1768681 agttctttaa cgatgcaagt gacgaaaagg ctggagacat ttttacaggg aacaaagaag 1768741 ctttatattg acggaaagtt tgttccgagt gcctcagggg caacctttga cactccaaac 1768801 ccggcgaccg gcgaaacctt gatgacgctg tatgaagccc aggctgcgga tgtggacaaa 1768861 gctgttaaag ctgcccggaa agcctttgac caaggtgaat ggagaacaat gtctccagct 1768921 tcgagaagca gactgatgta taagctggca gacttaatgg aagagcataa aactgagctt 1768981 gctcagcttg aaacacttga taatgggaaa ccgatcaatg aaacgactaa tggagatatt 1769041 ccgctggcta ttgagcatat gcgctattac gccggctggt gtacaaaaat aacaggacag 1769101 acgattccgg tttccggcgc ttattttaat tatacgcgtc atgagcctgt cggtgtcgtc 1769161 ggccagatca ttccatggaa tttcccgctc ctgatggcga tgtggaaaat gggcgcggca 1769221 cttgcaacag gctgtacaat cgtcctcaaa ccggctgaac aaacaccgct ttcagctctt 1769281 tatttggcag aattaattga ccaagccggt ttccctgccg gtgtaatcaa catcatccca 1769341 ggattcggtg aagatgcggg agaagcgctg acgaaccacg aagcggttga taaaattgcc 1769401 tttaccggtt ccactgaaat cggaaagaaa atcatgtcca ccgcagcgaa aagcattaag 1769461 cgtgtgacat tggagctggg cggaaaatcg cctaatattc ttctgccgga tgcgaattta 1769521 aaaaaagcca tcccgggcgc tttaaacggt gtgatgttta accagggcca agtctgctgt 1769581 gcgggctcac gtgtcttcat tcataaagac caatatgatg aagttgttga tgaaatggca 1769641 tcctatgctg agtcactccg ccaaggagcg ggacttcata aagatactca aatcgggcct 1769701 ctcgtaagca aggaacagca tgagcgcgtt ctttcctata ttcaaaaagg aaaagatgaa 1769761 ggagcaaaag cagtgaccgg cggaagctgt ccttttgaag caggatattt tgtcgcaccg 1769821 actgtgtttg cgaatgttga agacgaaatg accatcgcaa aagaagaaat tttcggaccc 1769881 gtgctgactg caattccgta cgaaacagtc gatgaagtta ttgaacgggc aaaccattca 1769941 gaatatgggc ttgcagccgg actatggaca gagaacgtca agcaggctca ctatatcgcg 1770001 gaccgacttc aagccggaac cgtttgggtc aactgctata atgtgtttga cgcggcgtct 1770061 ccatttggcg gttataaaca gtcaggactc ggacgagaaa tgggatcata tgccttggat 1770121 aattacacag aagtcaaaag tgtatgggta aaccttgaag actaacatgt atgtttaaaa 1770181 aactgctgcc tgccagcagt ttttttcttt ctgtaatggc agtaaaagac gctgaatata 1770241 tatgcttctg aaggagttga gcgtgatggg cacacttcag gagaaagtga ggcgttttca 1770301 aaagaaaacc attaccgagt taagagacag gcaaaatgct gatggttcat ggacattttg 1770361 ctttgaagga ccaatcatga caaattcctt ttttattttg ctccttacct cactagatga 1770421 aggcgaaaat gaaaaagaac tgatatcatc ccttgcagcc ggcattcatg caaaacagca 1770481 gccagacggc acatttatca actatcccga tgaaacgcgc ggaaatctaa cggctaccgt 1770541 ccaaggatat gtcgggatgc tggcttcagg atgttttcac agaactgagc cgcacatgaa 1770601 gaaagctgaa caatttatca tctcacatgg cggtttgaga catgttcatt ttatgacaaa 1770661 atggatgctt gccgcgaacg ggctttatcc ttggcctgct ttgtatttac cattatcact 1770721 catggcgctc cccccaacat tgccgattca tttctatcag ttcagctcat atgcccgtat 1770781 tcattttgct cctatggctg taacactcaa tcagcgattt gtccttatta accgcaatat 1770841 ttcatctctt caccatctcg atccgcacat gacaaaaaat cctttcactt ggcttcggtc 1770901 tgatgctttc gaagaaagag atctcacgtc tattttgtta cattggaaac gcgtttttca 1770961 tgcaccattt gcttttcagc agctgggcct acagacagct aaaacgtata tgctggaccg 1771021 gattgaaaaa gatggaacat tatacagcta tgcgagcgca accatatata tggtttacag 1771081 ccttctgtca cttggtgtgt cacgctattc tcctattatc aggagggcga ttaccggcat 1771141 taaatcactg gtgactaaat gcaacgggat tccttatctg gaaaactcta cttcaactgt 1771201 ttgggataca gctttaataa gctatgccct tcaaaaaaat ggtgtgaccg aaacggatgg 1771261 ctctgttaca aaagcagccg actttttgct agaacgccag cataccaaaa tagcagattg 1771321 gtctgtcaaa aatccaaatt cagttcctgg cggctggggg ttttcaaaca ttaatacaaa 1771381 taaccctgac tgtgacgaca ctacagccgt tttaaaggcg attccccgca atcattctcc 1771441 tgcagcatgg gagcgggggg tatcttggct tttatcgatg caaaacaatg acggcggatt 1771501 ttctgctttc gaaaaaaatg tgaaccatcc actgatccgc cttctgccgc ttgaatccgc 1771561 cgaggacgct gcagttgacc cttcaaccgc cgacctcacc ggacgtgtac tgcacttttt 1771621 aggcgagaaa gttggcttca cagaaaaaca tcaacatatt caacgcgcag tgaagtggct 1771681 tttcgaacat caggaacaaa atgggtcttg gtacggcaga tggggtgttt gctacattta 1771741 cggcacttgg gctgctctta ctggtatgca tgcatgcggg gttgaccgaa agcatcccgg 1771801 tatacaaaag gctctgcgtt ggctcaaatc catacaaaat gatgacggaa gctggggaga 1771861 atcctgcaaa agcgccgaaa tcaaaacata tgtaccgctt catagaggaa ccattgtaca 1771921 aacggcctgg gctttagacg ctttgctcac atatgaaaat tccgaacatc cgtctgttgt 1771981 gaaaggcatg caatacctta ccgacagcag ttcgcatagc gccgatagcc tcgcgtatcc 1772041 agcagggatc ggattgccga agcaatttta tattcgctat cacagttatc catatgtatt 1772101 ctctttgctg gctgtcggga agtatttaga ttctattgaa aaggagacag caaatgaaac 1772161 gtgaatctta tcaagcggag atgttcaatt ggtgtgaagc cctgaaagat cagattcaaa 1772221 agcgaggtca gcttgaccag tttgaagatc aaatcgacaa gatgattgag gctctggaag 1772281 atgaccaaac aacagaagaa gattggtata aacaggccgc tgccctttat cgggatatta 1772341 cagaatcaga tgatacaagt gaaagacgcg cttatgtccc tatagggaaa cacgtgctgc 1772401 caaagcttcc ttacaaatac tccgccttag aaccttatat atcacgcgat attatgatcc 1772461 ttcatcatac aaaacatcat caaagctatg tcgatggcct gaacaaagca gaatcagagc 1772521 ttaaaaaagc gagagcgaca aagaattatg acttaatcac tcattgggaa agagagcttg 1772581 cgttccatgg agcaggccat tatttgcata gtattttttg gttttctatg catccaaacg 1772641 gaaaacggcg tcctacaggg gcattgttcc aaatgataga cctttcattt ggaagctatt 1772701 ccgcttttaa agaacatttt acccaggcct ctaaaaaagt ggaaggcgtc ggctgggcca 1772761 ttctggtctg ggcacctcga tcaggacggc tggagatttt aacggcagaa aaacaccagc 1772821 tctttagcca atgggatgtg atcccccttt taccgcttga cgtatgggag catgcctact 1772881 atttgcaata caaaaatgac cgggccagct atgtcgatca ctggtggaat gtcgtggatt 1772941 ggcgcgaggc tgaaaaacgt tttgagcagg caaaagaagt cgtttggaag ctctattaaa 1773001 aaaagccccc tttcctcggg ggcttcgtgt gttaaaaaat acctatcaca tgcaaaaaca 1773061 cgatgatgat ggcaacagga gatagatatc gaatgagcag cagccaaacc gcaaaccact 1773121 ttcgtttgag attggaaccg cttttcagct cgtcaaacaa atcctgtttc ggtattttta 1773181 gcggaacaaa aatcgaaatc agtaacgcac ctaacggcat taaaatattg ctcacaagat 1773241 agtcagccgc atcaaaaata gacagatgaa atatagtgac gtcacttaag acaccgtatg 1773301 ataatgcaga cggcacaccg acaataaaaa tagcaatacc gcctaaccaa gcgaatcgtt 1773361 ttctcttatt gatatcgcct ttcgacagta ctgcgaccaa aatttccagc attgaaaaag 1773421 cagatgtcaa tgcagcaaat aaaaatagaa gtaaaaatgc taataaaaag ataattccga 1773481 acggcatttg attaaacaca gtcggcagaa cgttaaataa cagaaccggg ccttggtctg 1773541 gcttgaggcc gaatgaaaat acagctggaa aaatcgcaat tccggccatt acagcaacaa 1773601 gcatgttcat aacagttaca gatacagcgg actgtaccag attttcctgt ttctctaaat 1773661 aagcgctata cgttaccatg acagatacac cgacacttaa taagaaaaag gattgtccca 1773721 ttgcatataa aatggtattg gcatcaattg cagttaaatc aggcatgagg aaaaatttga 1773781 ttccttccat cgcgccatca agtgtaaccg aacgcaccat taaaatgatg aataatagaa 1773841 aaagcgccgg cattaatact tggcttgctt tttcaattcc gctgcttacc ccttttgcaa 1773901 caactaaaat tgttaccacc ataaagagca gctggcctcc tacagccaaa taaggatttg 1773961 aaatggtact tgcaaatatc gtatcaaaac cagatgtttg cgataaaccg ccagtgaagc 1774021 cttttataat ataaattaaa atccatccgc ctacgacact gtagaaagat agaagaataa 1774081 agcacgtcac catgcctaaa taaccgatcc aatgccactt cgttcctgga gcaagtgttt 1774141 tataggactg aacggcatct ttctgtgttc ttctgcctat gatgaattca cctaacaata 1774201 aaggcagtcc gattaaaacc gtaaataaaa taaaaataag taaaaatgcg cctcctccgc 1774261 tggttccggc aacatatggg aatttccata tcgcaccaag cccgatagct gatcctgccg 1774321 cggctaaaat aaagccgagc ttcgaagacc attgatttgc ttccttcacc gtatcactcc 1774381 tatttgatct aaccattata aaggttcatt gtaagaatat cttcctatat agtcaagaac 1774441 attttaatta gtttacatca tatatctata gacatctgcc aaaaactaat attgaattat 1774501 tcagaaaatt atttataata agagaatgtt atgaaatttg taagaatttc tgctgaagtt 1774561 cttgataagt gtgttaggag tgtttttatg gacatcatta gaaaaataag ccattttgca 1774621 ggacaaacct ttggcatatg ggtcattgtt tttgcagtgc tgggattttc tttcccatct 1774681 ttatttacgt ggatcagttc ttatattacg atttttctcg gcattatcat gtttgggatg 1774741 ggccttacac tgcaagccga tgatttcaaa gagctggtca gaaagccttg gcaagttatt 1774801 attggagtaa tagctcagta tacgatcatg ccgctcgttg ctttcggcct cgcatttggg 1774861 cttcatcttc cagctgaaat cgcagttggt gttattcttg tcggctgctg tcccggggga 1774921 actgcatcta atgttatgac attcttagca aaaggaaata ctgccctttc tgttgcggtt 1774981 acgacaattt ctaccttatt ggcacctgtt gtaacaccgt tgttgattat gctgtttgcc 1775041 aaagaatggc ttcctgtctc gccggggtct ttgtttatct caatcttaca ggcggtttta 1775101 tttccgatca ttgcaggtct gattgtcaaa atgtttttca gaaaacaagt ggcaaaagcc 1775161 gtacatgccc ttccgcttgt ttctgtcatt ggcatcgttg cgattgtctc agctgtcgtc 1775221 agcggcaatc gggaaaatct gcttcaatcg gggttgctca ttttttcagt tgttatcctg 1775281 cataacggta tcggttattt actggggttt ctttgtgcaa agcttttaaa aatggattac 1775341 ccgtctcaaa aagcgattgc aatcgaagtc ggcatgcaaa actccgggct tggggctgca 1775401 cttgccacgg ctcatttctc accgctatct gccgtaccaa gcgcaatatt cagtgtgtgg 1775461 cataaccttt caggttctat gcttgcaaca tattggtcaa aaaaagtgaa aaagaagcaa 1775521 gctggatcca aaagcagcaa tctatcactt taaatatgca tcaaaaaggg tacatcactt 1775581 tatcgtgatg tacccttttt tattatcctt ctaataaaag ctgttcagga tcttccagta 1775641 aatttttgat tgtcacgagg aaaccaaccg cttctttacc gtctacaatt cggtgatcat 1775701 aagataaagc gatatacatc atcggacggt tttcgaaacg ctcttcatca atggctacag 1775761 ggcgcagctg aatcttatgc atgcccagta taccgacttg cgggctgttt aaaattggag 1775821 ttgacatcaa tgaaccgaaa gtccctccgt ttgtaatcgt gaaggagcct ccctgaagct 1775881 cgctaagggt taatttattg tttcttgctt ttttcgcaag ctcgccgatc tctttttcga 1775941 ttcctgcaaa tgtcaggcga tccgcatccc gtacaaccgg aacgacaaga ccttcatcag 1776001 cagcaacagc gattccgata tcgtagaatt ttttaacgat caactcatcg ccttgaattt 1776061 ctgcattcaa cagcggatat tttttcaatg cagccacgac cgctttcgtg aagaaagaca 1776121 taaagccgag cttcacttca ttttgctcaa aaaattgatc tttgcggcgt tttctgagat 1776181 tcatgacagc cgtcatgtcc acttcattaa atgtagtcag catcgctgat gtttgctgta 1776241 cctctacaag gcgttttgca atcgtttgtc tgcggcgtga cattttttgc acttcaacag 1776301 gtttgtcaaa gctttgctgt gctttttgag cctgaggctg ctgcttttgc tgaggagccg 1776361 gttttgatgc cggtttttcg tacgcttcga catcctgctt gcgcactctt ccaagcggat 1776421 ctccagttgg aacttgagac aggtcaattc ctttttctct cgcaagctta cgggccgacg 1776481 gagaagcgat cgttcttgat tttgcttcag attgtgcttc ctcgctcacc tcttgtgcag 1776541 ctggttcagc ctgtttctct tcttttacgc tttccttgct ttctgttttc tctgtaggag 1776601 caggggcaga actttcaccc gcgccttctg aaatcgtacc gataatttct ccgacctgga 1776661 cggtatcacc cgaatctttc aatacctctt gaagtacacc cgattcttct gctgtcaatt 1776721 caacattcac tttatccgtt tctagttcaa gcagatattc accctgttct acatagtcac 1776781 caggctgctt taaccattgg gctattgttc cttctgagat tgattctgct aattcaggta 1776841 ccttaatttc cgccattttt tcatttcccc cttagttttt gcgagtcaag ctatcagata 1776901 caatacgttc ctgttctttt ttatgaactg tcggatctcc ctctgcaggg ctggatcgtc 1776961 ttcttcgtcc aatatattga acgcttactc cctctggtgc aatctctgtc aaatacgggc 1777021 tgatataacc ccaagccccc atgttctgcg gctcttcctg cacccaaacg atttctttca 1777081 ggttcggaag ttttgcaaat aattctttga ctccttttgc cgggaatgga tacagctgtt 1777141 cgattctcgc aatgtgaagc cactctttac cgtcttctaa cttattaaaa tgatcgctaa 1777201 tgtctataga cactttaccg ctggataata caagtctggt tactttttca tagtcatgag 1777261 aaagtcccga ctgttcataa acaggctgga agcggctttc gctgagctcc tgcacttccg 1777321 acaccgtatt tgggttgcga agaaggctct tcggcgtcat aatgacgagc ggtctgattt 1777381 cttcacgaag cagcatttta gcctgtcttc ttaaaatatg gaaatactgt gccgcgcttg 1777441 tcaggttggc aaccgtccag ttgttttccg ctgcaagctg caggaatcgc tcaattcttc 1777501 cgcttgagtg ctcaggcccc tgtccctcgt aaccgtgcgg gagcagcatg actaatccgg 1777561 atttttggcc ccatttcgcg cgtccggcag aaataaattg gtcaaaatac acttgagcag 1777621 cgttggcaaa atctccgtac tgtgcttccc acaaaacaag cgtttccggt gaatgcacgt 1777681 tatagccgta ttcaaaaccg agaaccgatc cttcagacag cgggctgtta tgaacagcaa 1777741 atgatgtgct gcagtcagat aagtgatgaa gcggcacaaa ttctttgccc gtctcactgt 1777801 catgaagcac aaggtttctt tgggcgaacg ttccgcgctc ggaatcctgt cctgttaaac 1777861 gaatcggtgt tccgtctttc aaaattgaag caaacgcgag tgattctgcc aaagaccatt 1777921 ccacttttct gtcatcatcg aacgccttgg cgcgtctttc taaaatgcgc tttagcttgc 1777981 cgaaaacatt aaatgactcc ggccagttga tcaattcgcc attcagcttg cggagcacat 1778041 caaaatcaat cgaagtgtcc acatctggga aaccgtttga tacaggctct ggaagttcaa 1778101 tttcacaagc agtgtgttcc tttttagacg gaactttctg atatgcatcc tcaatgcgct 1778161 tcgttaccga tttttcgatg ttttgaacga cttcctcggt aaccacgcct tcttttacca 1778221 gcttttcagc gaaaatttgt ttgacggtcg gatgctttct gacagcatca tacagcattg 1778281 gctgagtggt tgacggttca tccatttcgt tgtgtccata gcgtctgtac ccgatcaaat 1778341 caatcagaaa atccttgttg aatgtttttc ggtattcgac cgcaaactta acagctgaaa 1778401 gacaagcttc aggatcgtcc gcattcacgt gaacaatcgg aatttcataa cccttggcca 1778461 ggtcgctggc atattttgtc gatctggatt cagcgctttc tgttgtgaat ccgatcatgt 1778521 tattggcgat aatatgaatc gcaccgccta cttgataccc ttttaaagag cttaaattca 1778581 atgtttcagc tacaattcct tccccaggga atgcagcgtc tccatggatt aaaatggcca 1778641 gcgattttgt ttcatcttgt accgggtatc cgctttgtgt tcgcgtttcc tgtgccgctc 1778701 ttgtgctgcc ttcaacaatc ggattgataa attccaagtg gctcgggttg ttcgctaacg 1778761 taatgcgcgc tgattttgtt tcagcgtctt gaagctcccg attcgccccc aaatggtatt 1778821 tgacatcccc cgtccatccg tagctgattc caatggatcc ctcagacggt acaagatctt 1778881 tgttcggcgc atgctggaat tcagagaaga tgatttcata cggtttgccg agcacatgtg 1778941 ccaagacatt caggcgtccc ctgtgcgcca tcccgatgtt gacacttgtc gtgcctgatt 1779001 tgacagattg tgcaataatg tcatcaagca ctggaacaag agcgtccaga ccctcaatgg 1779061 aaaagcgctt ctgcccgacg aatgtgcggt gcaaaaactg ctcaaagccc tctacttctg 1779121 tcaatctttc cagcacagct gacagctttt cagctgagtt cttctggaac agctcgccag 1779181 attcaatctt tcttgtcagc cactcgcgct ctttgaagtc atgcacatgg tcaaattcaa 1779241 aagagatggt tcttttatac gtatttcgta aatactgaat ggcttctaaa ccgttcgaaa 1779301 tgtttttagg agcgtctttg cagatgacag acgcaggtat tgcttttatt tcctcttctg 1779361 ttagcccgta atcggataat ggaaaaagtt cgctcttttt ctcatccttt ctgagcggat 1779421 tgacggaagc gttcaaatgg ccataggttc ggatatcttc tgcaagtctg actgcggatg 1779481 cgatcttttg aatcagatcg gctgtaacac gtcccttttc ttttgttccc gaggcctctt 1779541 ttatatcgct tggcggagca ccgagctcgt cgaacatttc cttcaaatcc gggtcaatgc 1779601 tgttcggatc ctgggtatac tgatcgtaaa gctccagcgc atagccgagg ttcggaccgt 1779661 aaaaatcttc ccaattcatt cgttgtttca tactattttg aaacatttga atattacccc 1779721 caacttaaat aatcaagtga ttgattcact atcttgaaat aactttcgaa cgctgtgtcc 1779781 aaaattatgt aataaaaacg cttccaacga tattttacca ctgtttgcaa tttgattcta 1779841 ccttgattgt tcacaaaata gtaaaaaacc tttataaaaa acaaaaaatt taatcattcg 1779901 aaaaaacaaa cgccaaaaag cataggatta agggctatcc tatgctttta tgaagcagtt 1779961 ttttcagcag cggatacaaa acatccggta gctgatcaac atccgggaca aatatactga 1780021 attttccgta catatcctgg atcgtcttca tttgcgattc ttctatttct gagttggaga 1780081 gaaaaacatt tatcacttct attcctcttt ttcgggcttc gataaccgcc tcacttgtat 1780141 caacgatccc attttgttcg tagccaaatg cggccggctc tccatctgag aaaacaatta 1780201 agaacttttg cgcctcgctg cgatgcagca tttttttcgt catctgccta attgcgtacc 1780261 cgtcacggtt atcttcttct ggctcaagct gcataatggc cggtccagaa tcttgtctta 1780321 atgatgattg gaagggaata accgtattga aatagtttgg ctggcttttt tcggttgcat 1780381 catttgtgtc ctcccaaaaa ccgacaatct gatgcggaac cgctaccgat ttcaacgctt 1780441 cgtgaaacag cacgattcct cgttttgttt cgtccatttt gtcgaacatg ctggcggaac 1780501 aatcgaccag caatgtaaaa actgcgtcga tttctgaaga tggttcttgc tttttgtaga 1780561 acaggcgcgg atttcgctca gtgaagtaac gaagaagctt attgttcagt ctcccggcat 1780621 gaaggtctgt tctcggcaat gtttttttat gctccagcgt tttttgaatc atttgtttca 1780681 aacgcttttg atacgattca atcgtttttg cctgctgttt ataagaaagc tcttcttcac 1780741 tggttgccgg ctgcggttct ttataaattg gaaatgcata tttattttct ttgccgtcag 1780801 ccatacccgc tccgttcggc tggtcttttt gggactccag cgcttccagc ttggaatagt 1780861 ctttccgttt cgtttgtctg gctgatcctt gaacagagcc aagggcctga tctccatcgt 1780921 cgccttccct tgaagcatct tttcctaaat ctgattttgc gccgtgttca atatcaaatt 1780981 gaaggaagct tttagacggt gcttctgttt cccggtgcca tgtcggcatt tcttcttcat 1781041 ggatatcctc atcaccgtct gattgttttg gaagcgtgat gtcatcactc agcttcggcg 1781101 cttttttctc ttcttcaaat aacggctgtt ctgcagcttt tgcgtaatca agctcaggca 1781161 aaaagaagta ggtgttcaac atgtctttat cgagtacctc ttcaagtccg tccatgaggt 1781221 cctcaacaat tttcagaacc tgccgtgtcg aatctgcttc atacacacgc aagagctgct 1781281 gctcaataaa cgggcgcatc agatcgatat cttcacgcat ggatggaagg gtctcgagcg 1781341 gcgattccgc tgtgagcttg aaatagatcg cgcaaaagag cgcatcggta aaaatgcttc 1781401 gttccaaatt taaggtcagc tgggttgaga aatgttttct gtacatgtct tttcgcttcg 1781461 caaatacatg tttcgtaccc gggcgctcac gtttgatgca ttcttcgatc ctaatgtctt 1781521 caagcagcat aaagagctgc ttggcaaaac ttttaaacgt aagatggcga tggatatcat 1781581 tcaaaaagtt cgcaaactca tgcagcgagc tatatcttgt tccgactgaa cgcaggtaga 1781641 cgtcgctttt cagacccgct tccatgtcct cagctgccct gtctttccaa aagtggctca 1781701 tatagatttt cttttcaaat ggattgtaat aggactgaac gccatactcc acttctaccg 1781761 cttcactctt ggtgagtgtt ttggccaaat cagtcagcat cataaataaa aatgaatcaa 1781821 tcgtgctgtc gttaaatttg ataaatttca tcgcagcccc ctcattcaaa cagagtttct 1781881 gcaatatttc ggacagccgc tttttcccga tcatcatcaa gcttttctac aattccccgc 1781941 tcaatggcac gacgcggcgg aatataagca gctaaatcac atgtatcgat taaagctctg 1782001 atggatgccg cttcttcaga cacctgtccg ttattggcct gaacgatcaa gtcagaggaa 1782061 agcgtgataa atctgtcaat caatttctcg tctttcaagg ctgactgaga catgagcact 1782121 tgtttcagca gctcgccttt aatataaggc acatcaatga tgacaaaacg gtttttcaac 1782181 gcttcattca gaggaacagt tccgacatag ccttcattga tggctgcaat gactccgaaa 1782241 ccgcttttag cccgtatgac ctcgcctgta aacggatttg tcatcatttt tctgtaatct 1782301 aatacaccgt ttagaatagg cagtgtttcc ggcttcgcca tattgatttc atctatataa 1782361 agaaaatggc cttccttcat tgcctttgta acaggtcctg aaacaaactc gattgttgcc 1782421 tggccagatt gattttcaat cgttttataa ccgaccaatg cctcagcgtc caagtcgact 1782481 gaacagttga cgctgtgcat cggtttatga aaatagctgg acaatgtttc tgccagcttt 1782541 gtttttcctg aacctgtagg ccctttcagc aggacatttt tccccatggc taatgcaata 1782601 atggcgtcaa ataaaatggc ttcatcctcc gcctcatagc ctgatgttcc tataagcgat 1782661 tgaaactctg gggaaatagg ctgctcttta tatgataaaa gcttttgttg tatatcttcc 1782721 ggcaatgtta agtgctgtag ttgagttgtc atagacagat tccctttcct attcatattc 1782781 cattaacgag tatactaaaa aagcccctgt atgctcaata caaaagggcc tggatgatat 1782841 tactgcttct cgttatttcc caaaagggct ccgcagacaa tacgcgcacc ggaattgccg 1782901 cttgggtttg tcagataatc gtccgcttgt tcatgaataa taaatgcact tccgtcctcg 1782961 tcgagaatat ttagtttact tccttttttc agtgaagtgt caggcgcatt cattatgaca 1783021 tctacctttc catcagcacc gacttcaagg ttcggcagat ctccggcatg atgccccatc 1783081 ggattattaa agccgtgttc tttgttcagt ggattaaagg gaccgcccgc tgattcaaaa 1783141 tccggcctga cacaagaacc tttctcataa atatgaaaac cgagagaagc acctggacgc 1783201 aggctgtttg cggaaatatg aatatcgagg ccttcatcat ctgattcttt gatctctata 1783261 aaaccgactg ctttcccttc acgattgacc agctggacat gatgaccaaa cgctgacgtt 1783321 tcaaccactt ttttttccgg cacccggtta ggagggtctg gaggtttttt ttgtccgcat 1783381 ccggcaactc ccagtgccgt cagcatcatc aacagcaaga gacggtgcat actgtctccc 1783441 ccttgttttt tctaacagtg tggtcaatca ttgtctggta taaacaaaaa agcctataaa 1783501 aggctttttg tcatactcat ttttaaaaat aacttcttgc gcccaagtac cgctgtttcc 1783561 aatacgaatt gctgagattg gaaatgtcga cgcccgatga gcttgcatga ataaaatcac 1783621 cgccgcctag ataaatcccc atgtgagacg ggccggattt atatgtggta aagaagacaa 1783681 agtctcctac tgacggctgg ctgactttct gcatgacatt ccaataccct gccgtactca 1783741 atcttgatat agatgataca ttattaatga ggtaataaat gaagccgctg caatcaaaac 1783801 cggcaggcgt gtttccgccc catcggtaag gcactccgac atattttttc gcttccgtta 1783861 tcattctgtc aatcttcgaa cctatttgaa tgtttgaccc tgagttatct tttggctttg 1783921 ttggctttgt cggatttgaa ggattagatt ttgatgctcc cgaaatagtc agaacctgcc 1783981 cgatttgcaa cacatccgat gataaattgt ttttatcacg gatgctttgg acagtgactc 1784041 cgagccgatt tgcaattttc cacagcgaat cgcctgcttt taccttgtac gtcgttgttt 1784101 ttgagggatt ggagtttgac ggctttttgg aaccgctgtt tccgttctta ggtgaactgc 1784161 ttccttttat tttgagcacc tgtttaggat aaagtgtatc tgatgttaag ccatttaagg 1784221 tttttaattc ggctacagtc atatttaagc tgtttgcgat tttccacagt gagtcaccaa 1784281 gcttgaccgt atatgtactt tttgaagaac ctgaagaatt ggaaccgctg tttttctttg 1784341 atccatttga tccgcttgaa ctgcttgtcc ctttgatctt aagcttttgc cccggacgaa 1784401 tcaggtcact gctcaggctg tttaagcttt taagctcaga aacactcatt ttatgatttt 1784461 tagcaatcat ccatagggaa tcaccatatg caactgtgta tgttgatgtt ttgcttgaat 1784521 tagatgggga tgtcgtgctt tttttgctgc tttcaggaac cttaagactt tgtccgacat 1784581 aaagcaccgt tgatttcaat ttgttttcgg atttcagagc tgatattgtc gtatcatact 1784641 ggcgggaaag tttccaaaga gagtcaccgc tttttacttt tatcgttttt gcttccgcgg 1784701 gtgctgcggc catcgacgac ccaacaactg cagaaacagc caagccggct acaatcttct 1784761 ttttcattca ttcaacctcc taaactgttt ttttgcaaaa acagctagta ttttgtttcc 1784821 aaaaatggca cacaactgtt ttatcgtcaa tttttcagca agttaaaccc ttttcaaaca 1784881 tttggcgcag cattttcagc atcgttcgac ctttaaacct tcaaataaac atctaacatt 1784941 ttacataagc acgatatgtt tttcgaaagt ctaaggaact atttaagcga gggtaaaaat 1785001 gatggttttc tattgatgaa cgaagcagtt tctcctcctt tcttgtctat ttttctaatc 1785061 aattctctat cggcgtgtca aatcccttcc tctgcattct tatgaaatgg caaaaagcct 1785121 gttctttcga taagaacagg cttttacact atgcatttgc tgattgagtt ttttgtttta 1785181 cagcttcaag aatgctgtcg gctgcttttt tagagccgcc tgccgctttc agtgattgtc 1785241 caatttcttt tgccttttca gcatacgaac gattattcat tacttcttgt atcgtctctt 1785301 tcagtaggct ttcagacaat tcttcctttt taattacttt tcctgcgccg actttttcta 1785361 cctgatctgc gacaacaaat tggtcgcctc ccatcggaat gacaacgagc ggggtttcaa 1785421 aatacaaacc ttcacttgtg ctgttcattc cgccgtgggt cacaaataag ctggctcttt 1785481 tcaagatctc aagctgaggg acatacgggc gtacaatgaa attctccgga atgtcgttta 1785541 actcacttgt tttaatatgc ttgccgatgg aaagcacaac tttaccgtca aagtccttac 1785601 acacttcaag gcattgatta aaaaactgct tttgattatt aaaaatggtt cccattgaaa 1785661 taaacagcac gttttcattg tcaatctgat caaatgggaa atcattgttt ccggctcttt 1785721 ctgtaatgga aggaccgaca aatacatatc gctcgccaaa ttgctcagcc agtggctgaa 1785781 atccccttga tgtaaagacg attgtcaagt caccatcagc taaaaaaaca tcaaatggct 1785841 tcttgatctc tgcttgaaaa tcagcattta acgtttctgc aagctgctgg tatgattcat 1785901 aatgaggcga atcttcaagt gatcctttca tgtacgctcc catcatttcc ttcgcaaatt 1785961 cctcattcat cgcaaaggtt gtacacaatg aaaatcttgg cagcttcagc atgttggcaa 1786021 tgactttacc cgcgagaaga tggtgatcat atatgacata atcatacgat tcatgtttga 1786081 cttcctcata aatatgagtc gcgatatcct tacaggcttt caaaaaagcg cagagcattt 1786141 ctgtgaaatc tctttcttca tcgccggttg cgtttttccc gaagtaatct cctctgaaat 1786201 catgatactc acgaaactct atatcaagag ctgtgatttt ttctttatat tccttcactg 1786261 cgtagtacgt aatgttttct ccccgggatt tcagctcctt catcacaccg atagagggat 1786321 taatatgccc ttcaccgggg aaaccgatca ttaatacatt agccatgcgg cagcaccctt 1786381 cctttgagaa tttatgtaat attttatacg gtactataaa tgcataaaca ggtaaagtat 1786441 ttcacttaat taatattcat catatataac ttttctacca gtttatattc cctgtcttca 1786501 agacaaaaag cattcagctt gaagcgaatg ctttaataaa gatgcgaatt cagtcatttt 1786561 gtctcatgat aggattctta atcaggccct ttttattatt tttacgttct tggtgaaatt 1786621 aacggatata atacaccgtc tttggcaaac gacatcttcc ctgtttcctc tgaaaccacg 1786681 agcaccagtg catccgtata gcccgacata ccaagagccg cccggtgccg ggttcccaaa 1786741 tggatatcca cttccttcgt cgtcagcggg agcacattgg ctgctgacac gagtttgttt 1786801 tccctcacta ataaagcgcc gtcatgaaga gggtttccgg gaaaaaagat gctttcaatt 1786861 aatgaagagc tgatctcggc gtgtagggag gtgccttttt gaataaaacg ttcaaccggg 1786921 tctgctcttt caatcacaat taaagctcca tgcttatgtt ccgataaggc tttaatcgcc 1786981 ttggccagct caataaatgc cggcgtaaat tcctcaatgt atgattgcaa ataaaaggag 1787041 gatgcaatcc cctgcatgtc ctgaaaaacg tgccccaaat catctaattc acaaaggaga 1787101 cactggtctt tttcgtgaag cgttttcaag attagagatg catcacctaa tatttgctct 1787161 aagtacacct gtattttccc cttgaacgca ttttctgata tctgctcata gcgcatagcc 1787221 ttcatctcct gtttaaattt ccaacttttc acgaatgctt atcttattga tgcacattct 1787281 attggtaaag gagggatgta aagaatggaa atcgaaagaa tcattcagta tatttgcacc 1787341 tttttaggcg tgatttcgct ttcttttatt tatgcccaaa tgtttagaaa aacgaaaccg 1787401 acaaaaaaag aataggcccg gcgttcattg ctttttatac ataaaatgtt ataatttctc 1787461 tcgttatgaa aaagaaacgg agatcaatgt atgaaagaaa ctcaaaacgc ccgggaaaaa 1787521 atcaaacagc tcttgcacat tttaataccg atattcatta cccaagcggg gctttctctg 1787581 atcacttttc tagatactgt gatgtcaggg aaagtcagcc ccgctgattt agctggtgtc 1787641 gccattggct caagcctttg gacccctgtt tacacaggac ttgcaggtat attaatggcg 1787701 gtcaccccga ttgtcgctca gttattaggt gcagagaaaa aacagaagat tccctttact 1787761 gttttacaag ctgtatacgt ggccgcgctt cttagcatcg ccgttttagt gattggatat 1787821 gctgcagttg accttattct tggccgattg aaccttgata ttcacgtgca tcagattgct 1787881 aaacactttt taggcttttt atcactggga attttccctt tatttgttta caccgtgttg 1787941 agatcattca tcgactcatt aggaaaaacg agagtcacca tgatgattac actcagttct 1788001 cttccaatca attttgtatt gaattatgta tttatcttcg ggaagttcgg aatgccggca 1788061 cttggaggtg taggcgcggg actggcatcc gcgttaactt actggtgtat atgcatcatc 1788121 agttttttca ttattcataa aaacgcaccg ttttctgaat acgggatttt tcttaccatg 1788181 tataagttct cttggaaagc atgcaaaaat ttgctcaaaa tcgggctgcc tattgggttc 1788241 gccgtgtttt ttgaaacgag cattttcgca gctgtcacgc ttctcatgag ccattttcat 1788301 acagtgacca tcgcgtccca ccaggcagcc atgaattttg cgtctctttt atatatgctg 1788361 ccgcttagcg tgtccatggc tctaacaatt gttgtcggat ttgaagcggg tgcagcccgt 1788421 tttaaggatg cacgctcata tagcttaatc ggcatcatga tggcgatcgg cttttctttg 1788481 ttcactgccg cctgtatcct tttattcaga gagcaaattg cgggcatgta cacttctgac 1788541 cccgatgtgc tccggctgac acagcacttt ttaatttatg cgctattttt tcagctttcc 1788601 gatgctgttg ccgcaccgat ccagggagca ctcagagggt acaaagatgt gaactatacg 1788661 cttgcggccg cttttgtctc ttactgggtc attggccttc cggtcggtta tatggtcggt 1788721 acgtttacaa gcctcggtgc attcggctat tggattggat taatagcggg actcgccgcc 1788781 ggagcagttg ggctgttttt caggctggca aaactgcaaa aacgttattc gcaaaaacaa 1788841 cacatttaaa agaggtgatc aatcatggca aaaaacaaaa aattattcga gtatctttcc 1788901 cagcatgcgg aaaccatcag ttcaacatgg tatgaaacaa tcgaggagac tgatcccaat 1788961 tccatttatg cctcaacaga ccctgttgtc attcacaatt taaagagcca gaatcttgcc 1789021 tttaactata aaataaaccg tatttttata gatgatgagg acgtatactt gcctatactg 1789081 aaagaatggg cctttgaagt cacacaggat caagagcatt taaaaactcc tatccactat 1789141 attattcggg agtttgtcag agtgagagat ttatatgttt cttatgtgaa agaatttgtc 1789201 catctcaatc agaatactgt gaaaagcgaa gaagccgaag acctgtatca cgcccttata 1789261 aaagcgtttg atcttgtgat tcatattttt atagaagaaa tgtacaaaaa cacaagcctt 1789321 cagcttcagg cccaaaaaga tatgattact gaattgagcg ctccggtcat cgtgctgttt 1789381 cacagcgtcg gactgctgcc tttaatcgga gatattgata cagtccgcgc caagctgatt 1789441 atggaaaaca cactgcatca atgtgcgaaa aaaaaggtga cacaactgta tattgatttg 1789501 tcaggagtag ctgtgattga tacgatggtt gcccatcagc tgttcagtct gattgaggcg 1789561 cttcgtttaa tcggtgtttc ttcaactttg tctggaatcc gtccggaaat cgcgcaaaca 1789621 gcggttcagc taggtttgtc tttcgaaggt atttccttga gatccactct cgcttcagct 1789681 attgcatcgg acttaaaatt aaaaaaggta taaggcttaa ggccttatac ctttttgatt 1789741 aatcattcca ttgatacgtc caatatattt cttcttcaaa ccatgttgcc ataacaggtt 1789801 cattattttt caatttctct tcaagctctc tgagcatgcc ttctgtttgt gtgcggtgag 1789861 ctcttaacgc attcatttta atatcagcta cttctttgat atcaagtacg acatcagctt 1789921 cgccgagaac ctcttctctg ttgcgggtaa tggccatgca gattgtacgc ggacggtctt 1789981 ctttcttttt gcggtataat gcacggataa ccgcttcccc gcatgcatca tggtcagggt 1790041 gcacaccgtg tccgggataa aatgtgacaa ttaaacttgg ttttacatca tctatgatct 1790101 cttccatgat atcagctaaa tactcatcgt cttcaaattc gagcgttttg tcacggagtc 1790161 caagcatccg aaggtcattg atatccattt ctttgcaagc gttgatgagc tcttgttttc 1790221 ttagcagcgg caacgtttcc cgattcgcga aaaatggatc gcccatattt ctgcccattt 1790281 cacctaaagt ggcgcaggca tacgtaacgg gaatgtcttt ttttctgttt aaggcaatga 1790341 ggcctgccac tccatatgat tcatcatcag ggtgaggcag gattactagt acatgttctt 1790401 tcattattat tcaccctttt ctttaaactg tgaacggttt ttcgctgatt tgcagagaaa 1790461 tagccagttt accgcccggc aggtgtcccg ccattaataa acggttttct tcatctaccg 1790521 tgtattcagt caagccttca gcataaatcc agccttcttc tgttttcaag ccaacgcggt 1790581 aaggcccgtt gcctttgatt tttgcctgat gataagtgac ttttgcattg cgaatatacg 1790641 caacaaccgt catgttcttt tcatttaagt gcgctgaata agaacctgtg gtggtttcta 1790701 aatggatata tacagggcgg tccgcatatc gttctaaaga tgcttgcaca tcttctttta 1790761 tgatcgcttt catgattgct cccctctttc ttcttttaaa tactctgcac gttctgtatg 1790821 taatttgacc agctgatatt tcacagccgg ttcgagctgt gaattcacaa tgcgctgaat 1790881 cgcggcaaaa tatttttcca gcatcggttt tcggagtctt ggatgtgttc gtttatccaa 1790941 gagctcaaga tcaatcgcct ctgctaccgc ttctgcgtca tcatgtgcga gagatcggtt 1791001 attccaaagt gaagcatagg ctttcactat ctctttatca ttgtccatcg tcttgctcct 1791061 ttatgtctta catacatgaa atgattatac ataatatatg catcagctga aaagccaaag 1791121 gcctcaatgg ctttttgacg cccgtttcca cttcacttgt gaaaacgtaa acaagagcag 1791181 cgcagcccat atacagctga atgtaaaagc cttcgagctt gaaaatggct catggtaaac 1791241 aaacagcccg atcagcaggg taatggtcgg cgcaatatat tgtaagatac cgacttgata 1791301 cagtggcagc cgtttcgctc cttccgcaaa caataagagc ggcaaagccg taaacacacc 1791361 ggccaaaaag agaagcagcc acgtccctcc gctttctgca cccgctggct gaacatgtcc 1791421 gctgaacagc aaatacccca atgcaatggg cataatcatg aatgtttcca gcgttaaacc 1791481 gatggcgctc ggcaggcttg ttcttttttt gcttaacccg tacagcccaa agctgaatgc 1791541 gagcagaagc gcaacataag gaatggagcc gtattggaac gccgagatga tgacaccggc 1791601 tgccgcaatc gaaacggcca ctaattgcag gcgattcagt ttttccttta aaaataaaat 1791661 cccaaggagc actgatacaa gcggattaat gtaatagcca agactagcct caagcaaaaa 1791721 gccatggttg acagcccata tgtatacaaa ccagttgatc gaaatcagga tagaagcaag 1791781 aaataaagag aggatccctc cgttcttttt cagagagcgc aactcctgcc atcctatttt 1791841 ccattgccgc aagaaaaaaa gtacgataca cataaaaaca aaagaccata taatacgatg 1791901 agccaaaata tcaagagccg gcagctgttc gagaagcttc caatagagcg gaaacaggcc 1791961 ccacatgata aatgaaacgg ctgtgtaaat aacgcctttt tttgtttctg catgttgcat 1792021 tgatatccct gcctttcttt agagcatctt atattatatc acgtgaaaga tctggtgggc 1792081 atatactatt ttgtccgtga agaaaggatg tgaagacaat gtttgagtgg aacaagtact 1792141 ttcctttcca caatcaattt tctaaagaag cattaaaaaa agctgatccg aaagaagttg 1792201 aaacgtatgt caatcgtgtg atggaaagtg tgttcggcag tgattatgcg gctcaatttc 1792261 ctttccgcga tcctctcccc caaaaagaac atcccgccaa acctgatgca aaacctgatg 1792321 tcaaacctga tattgatata ttcgaaacag cagaccatgt gtttgtaaag gtgccaatca 1792381 gcgaagaatg gctggaacaa gtgagaatca aacacacatc tcacgaatta tggttggaaa 1792441 acctcccaag agcagatcat ccgaaaaaag taaaccttcc ttgtttagtc aaacgcaaag 1792501 gaacaaaagc cgtctataag gatggccttc tggaagtcat gtttcaaaag cagcaagact 1792561 acaatatgtc cgaggtagaa atcatccgat aaaaaacggc ctgcaatcga tgcaggccgt 1792621 tttttattaa tagaagccgg gatatccccc gtatggcacg ccggcaccaa aaccgtacgg 1792681 tccgcctcca tatccataag ggccaggagg ataggcatag ggacgagaat agttaaacag 1792741 cgcactcccg agaaaaccgc ctaataaacc gccgactaga ggagcgccaa acaaaaaagg 1792801 actacgcgcc ggatatccgg ctggacctgg gattccgcgt aaatacgaat gatgagggta 1792861 catgattttt tcctccttta tgtctgccta tacgtaaagt attcagcaag gaagaaaaac 1792921 gattgggcta cggactgtct atgattgtta catcacaagc cctgccaata acacacagcc 1792981 gagccctgta accgaaagaa ctgttgtaag cagcgtccag gtttgaaatg tttctttcat 1793041 gctcaagccg aaaaattcct ttaccatcca aaatcctgca tcatttacat gacacgcaat 1793101 gacactgccg gctcctgttg caagcaccat taacgcaggg tttacactgc cagcctccat 1793161 aagcggagct gccattcccg ctgtggtaag cgcagccacg gtagcagagc ctagacacag 1793221 acgcagaacc gcggcgatgg tccatgcaac gaatagcggc gacatgtttg tttgacggaa 1793281 aaaatcagcg acataatcgc cgactccgcc gtcaatcagc acctgtttaa acgctcctcc 1793341 ccctcctatg atgagcagca tcatcgcaat ttgcgaaatt gattctgaaa tagatctgcc 1793401 gatttcctgc atagatattt tacgggcata tcccatcgta tagagtgcaa gcaacagcga 1793461 aatgagcatt gccgttcccg gagtgccgat aaattctata atgtcttttc cttttgaatg 1793521 ttcactcaat aataaagaaa aaattgttgc cattgccata aagataaccg ggaataaaga 1793581 cgtgacagca ctgatcgcaa agcccggtgt ttcatccagc tgaaattctt tccttggtcc 1793641 taaccccgat aggtttccat gcttttgata cgcaccagga aaccgtttca tcgcaaattt 1793701 attaaataaa ggcccggcaa tcacagttgt cggaacagcg atgatgattc caaaaagcag 1793761 cacctggcca atatgggcac catatgcaac tgagatagca gttggagcag gatgcggggg 1793821 caaaaatccg tgagtaacat ttaaggcggc ggccatcggg attcccagat acagaaaagg 1793881 catttttaat tctttagcaa tcgcgtaaac aatcggtatc aacagaacaa gaccgacttc 1793941 aaaaaatagg gcaatcccga tgataaaaga ggcaaccaca accgccgcct gtattcgttt 1794001 cctcccgaat ttgtcaatca gcgtaatggc gatccggtag ccgcccccag catctgagac 1794061 aagcctccca agcatcgcgc caagtccaaa cactaaagct aaatgcccca gctgcccgcc 1794121 aattccagtc tcaattgaaa gaacaatttt attgatatcc attccaagtc cgatggctac 1794181 taaaaatgaa acgacaatca gtgagacaaa ggtatttaat tttactttaa taatgagaaa 1794241 taacagaatc agcactccga cagctacaat taaaatcggc atggtacccc tccaaaagtg 1794301 ttttatatga ttctcgcgac aatgttttgg cgcttttcat gcctagatga acagaaagcg 1794361 ctttcattaa taactaaaaa cgtcttggtt atatgattgt tatcttttga tcaactaata 1794421 tgttcatact aatctcctaa tcaatgactg tcaatcgttt ttatgagctt gtctcgatta 1794481 cctaccgcct aacccaatga tttattagtt atatgttgat taacttttgg ttatatgtta 1794541 tgttttttaa agttgactgc caatcattat atctctccat tgtctggaag caaatgagac 1794601 aatatgagaa cagacggata acaacttcat aagaggagga gtacacatgc cattattgcg 1794661 ttttgatgta attgagggcc gtgatgaaaa atcgctgcaa ttgttattag atactgctca 1794721 ccaagcgatg gttgaagcat ttggtgttcc ggaaagagac cgttatcaaa ttgtccatca 1794781 gcatcccgca aacgagctta taatccagga tgcgggatta gggtttcaga gaaccaagga 1794841 tatggtcatc attagcatga caagcaaagc aagaaccgaa agccaaaagg aaaaattgta 1794901 tgctctgctt gctgaaaggc tagaaaaaaa atgcgaaatt tcccctgacg acctcatggt 1794961 atctattact gagaatggtg acgcagactg gagtttcggt ctcggtgagg cgcaattttt 1795021 gaatggaaaa ctataagatt tcgtctcccc acaaaaaaaa gaagagagag ctccaaagaa 1795081 gctctctctt ttttcataaa tgcggaagtc atcagtatag aagcatccag caatacgaaa 1795141 aacctggatc tccttttata tccggtttaa atgccaattg gaagctgact gggttttggc 1795201 tgaaaatata aaattttgct gatttgcata ataagataca tcataatccc catttacaat 1795261 aggttggatg ttatagctta ttgatcattt cctattttat atatcccctt catatgcaca 1795321 tgacattttt gccaatccgg aaatatcagt ctgacaaata taaaaagtca tgtaaacggg 1795381 tgtgaaccgt acttacatga ctcaccatgg aaacaaaggc tctttttcag gtgccgcttt 1795441 ccttatttct cttcttcaca cactgtgtca ccaggctcgc aaaattgatc ggcccatgcc 1795501 tgcatttctt gaaatacagc ttgaagcgct gttccttttt cagtcagcgt gtagatgact 1795561 ttgaccggcg tttcagggag aacctgccgt tcgacaatct cgttttgttc aagctccttc 1795621 aagcgctctg ccaacatttt ttggctgatc atcggtattg tttccgttat ctctttaaac 1795681 cgtttcggcc catccattag cacatggatg atcagaccgt tccatcgttt tcccagcaat 1795741 gagaatgcgg attccatttt agggcacatc gtatttccca taagtcttca tcccttcatc 1795801 tattgattga catgtattca atgatccatt acaataatct ttcaagttac atttagtaag 1795861 cttctaactt ttctattatc ataccacgtt tatccgaagg aggaaacact atgacgaata 1795921 ctctggatgt tttaaaagca cgtgcatctg taaaggaata tgatacaaat gccccgatct 1795981 ctaaggagga gctgactgag ctattagacc ttgccactaa agcgccttct gcttggaacc 1796041 ttcagcattg gcattttaca gtattccaca gcgatgaatc aaaagcggag cttcttcctg 1796101 tagcgtataa tcaaaaacaa atcgttgagt cttctgctgt tgttgccatt ttaggcgatt 1796161 taaaggcaaa tgaaaacggt gaagaagttt atgctgaatt agcaagccaa ggctatatta 1796221 cggatgaaat caaacaaaca ttgctcggcc aaatcaacgg tgcttaccaa agcgagcaat 1796281 tcgcacgtga ttccgctttc ttaaatgctt ctttagctgc tatgcagctt atgattgccg 1796341 caaaagcaaa aggttatgac acttgcgcaa tcggcggatt taacaaagag cagttccaaa 1796401 agcaatttga tatcagtgag cgctatgttc cggttatgct tatttcaatc ggcaaagcag 1796461 tgaagcctgc gcatcaaagc aaccgtctgc cgctttcaaa agtatcaact tggctgtaag 1796521 gatatgaaaa accttagtcc gaaatccgga ctaaggtttt tttatacaat cgcctctttg 1796581 taccattcac gagcctgttc agcttcatgc tgagtcagct gatggccccc gtcctgccag 1796641 taaacggagg ctgatgcccc gctgtcacgc aaatagcggt aaagctcttc tgattcttcc 1796701 ttcgtgcaaa gaggatcgta tttcccggca ccgataaaaa cagggagccc cgccatatca 1796761 ggcagctcga taccccgaat cggaaccatt ggatgatgca gaatagcccc ttttaacaca 1796821 tctttataat gaaaaagcag gcttgccgca atgtttgcgc cgtttgaata accgactgca 1796881 atcactcggc cgcgattaaa ctgatgcgtt tctgcagcct cgtcgataaa atctttcaat 1796941 tctcttgtcc gcaccacaag atccttttca tcaaaaactc cttcactcag acgtttgaaa 1797001 aatcgcggca ttccattttc aagcaccgat cctctgacac caagcaaatg ggcatcaggg 1797061 tctataaacc gccccaatga aagcagatcg tgttcattac cacccgtgcc atgcaacagc 1797121 aaaagtacgt tgtcagatgt tcctttctca taaatatgct tcattataaa ttcccccttt 1797181 taaagttcag gtaaaatgtc tgtaatttgt tgtctatgtt tctccagcca ttcaggcagt 1797241 tttaaggaag tccctagctc agcaaacgtt tcatctgtca taaagcccgg ttcatctgtg 1797301 gcaatttcaa ataagatacc gcctttctcc ctaaaataaa ctgatgtaaa gtattccctg 1797361 tcgagaattt ctgacgaagg cagatggttt tcagcaataa tcggcagcca tttcgcctgt 1797421 tcctttttct tagtccgaaa cgctacatgg tgtaccgtac catatcctcc gactcctctt 1797481 ttttcaggat gtaaatggac atcaatgaca ccgccgaccg ccgctgaaga tgccagtctg 1797541 acaatctggt cttcttcggc cactttggtg tatccaaagc tttccgttaa caattgtatg 1797601 gtcgcctgcg ggtcgtagga atatagcagc acacctttca ttcccgtaat tgcttcattt 1797661 gttgtgatcc cgtcaggcgt ccactcgctt ttgccgcttt tcgcatcctc catgatcgcc 1797721 agcggaaggt cttctgtatc atcaaaaata agaccttttt caccaaacaa cgttttttcc 1797781 tctaggctca gcccgctttt ctcaagacgt tccttccaaa aagacaggga gcctgaggga 1797841 actgaaaagt acacccggcc cgcttggcct tttcctaccg ttccctgtcc gcttccttgg 1797901 aacggaaaaa aggtcattat tgtaccggga tctccgtttt gattcccaaa gtaaaaatga 1797961 tacgttccgg gatcatcaaa gtttactgtt tttttaacga gcctgagccc aagcacttct 1798021 gtataaaatc gcaagttttc ttgcggatct ctggcgaatg ctgtgacatg gtgcaatcct 1798081 tctgttttca ttttctcact cctatttatc tcgatttcaa gatatttatt attttaaacc 1798141 tttattgaaa aggatgcaaa ccatgtgttt tgattaaata attgaaaaaa tcattttttt 1798201 ctaataatta tcttgtgatc ttttcttaca actgctatta tagtgagcat tatcatgttt 1798261 caggaggaaa gtaaatggtt aaaaaagcac ttattgttat tctcattctt ttgccattcg 1798321 ttcagctcgc gcttttgccg cttgtgaatc gaatagaacc gattatgttc ggcctgccgt 1798381 ttttccactt ttggctgctg ctgtggatta ttgttacgcc gttatgctcg tttggcattt 1798441 atcagatgca aaaaaaagat ggaggacttg aataatgcaa gggaatctga ctgcacttct 1798501 cattactgct attattgttt taaccgttgt ctgtatcggc tttctcgccg gaagagacaa 1798561 atcctcacgt acttctgtgg aagaatggtc tgtcggcggc agacgcttcg gcggtcttct 1798621 cgtctggttt ttagtaggcg ctgaccttta tacggcctat actttcttag ggttgaccag 1798681 tactgctttt acaggcggaa gtgttgcatt tttcgccatt ccttattctg tgttggccta 1798741 ctttatcgcc tacttcttct tgccaaaact ttggaaagtt gcgaaaattc ataaattaac 1798801 aacactcgcg gattatgccc gggaacgttt taacagtaag cttttggcaa gcctcgttgc 1798861 catcgttggg gtactcatgc ttattccgta catatgcctt cagctgagcg gcattcaaga 1798921 cacgcttcag gttgccggca ctggctatat taacgtaaaa ttcgttgtga tcatttcatt 1798981 tattcttgtt gctctttaca cattcttcag cgggattaaa gggcccacat atacagccat 1799041 cattaaggac attttagtat gggtcattat gctgtttatg gtggtgtccc tccctctcat 1799101 tcattttaac ggctggacgc caatgattga cacgttagtg aaggaagcgc cgcaaatgct 1799161 gacgataccg tcagaagggc caaaaggcat tccttggttt atcacagcat ctattgtttc 1799221 cgctctggca ctttttatgt gggcacatgc cgctacaggt gttttcacgg cgaaaagcgc 1799281 tgatgcagta agaaaaaaca gcatgttttt gccgctttat aatatcgtgt taattttggt 1799341 tatttttctt ggctttatcg cctttcttgt tctgccggaa gatacaaatc caaggctggc 1799401 gctgctgcat ttgattcaaa catcttacgg cggcgtggca caaggctttg catatgccac 1799461 tatcgctctt gcttcattaa taccttgttc cattatggca atcggcgcat cgaatttatt 1799521 cgccaacaac ctataccggg atttgattca tccgaatgtg tcgcaaagca agctgactct 1799581 tgtcacacgt tcaatggtgt ttgttgtcat cggtcttgcg ctgctgtttg gaatgctgtt 1799641 cccgactgcc ttagtgacac ttcagctatt aggtgtatcc ggtatggtgc aaatcttccc 1799701 tgcgattgct gtcagcctgt tctggaaaaa ccaaacgaaa gaagcaacgg ttatcggatt 1799761 attagccggc ctagcggtaa cgtttattgt gtatatcact caatccgcac atggcattta 1799821 tgaaggattc tggggattgg ccgccaacat gatcgctgtg gtcatcctga atccgctgtt 1799881 cgttaaaaac gcgggatcca atcctgtcat tgaaggttta tttggcaaaa aacaagacgc 1799941 taatccaaat caaaagggcg cataaaaaaa ccatacgcgg cagccgcgta tggttttttt 1800001 tacatttctt ttttcagtgt ttcaattgcc ttttccattt gcgtatcatt atcagacagc 1800061 ttcttttgaa gttctatcat taatttcgtt gttgtatcgc cagtcagtat gcctgtttca 1800121 ttcagcttct cttttttctg gaactgtttg acgacagata caaaatcctg gtcatacata 1800181 ctgttaacct ttaccttgta accaagtgct ttgagcattt tctgagccac tttgacgttt 1800241 gtgcctgtat cacctgattt gtacgtttta tctgcgtcca aatacggcag cttcgcgtaa 1800301 tcaggcagct ctgctttcac ttgaggcttg atgccttttt tgtgaatcca ttcgccatca 1800361 gcagtcagcc atttggcaac tgtcagtttg acggtagagc catcatcata ttcttttgcc 1800421 gtttgtactg tacctttgcc gaatgtcgtc tcgccgatta acggtacgtt tgacgattca 1800481 tgaagggcag cggccataat ttcggctgcg cttgctgtac cgtcatttac taaaacgacg 1800541 gtcggcttgg tcactttccg ttctttttcg gccttcatga cttcttttga accgtttttg 1800601 tattcaacct gcatgatgtt tttcccttta tcaatgaaca ggttgctcat cgtaatcgcc 1800661 tgttccatta agccgcccgg gttgcctctc aagtctaaaa tatagccttt ggcgcctttt 1800721 ttctctaaac tgtcaatcgc atctgtcagc tctttagctg ttgtttcaga gaaagaagtg 1800781 atttgaattt ctccgatgtt gttgtctttc atctctgaat agacagtctc tacaggaatg 1800841 gtatcgcgct taatggaaag atcgatattc cccactcccg ctctgttcag ttcaagcttc 1800901 acctttgtgc cctttttgcc tcggattaaa gcgacggctt catttacatt catgcctttt 1800961 acgctttttc catttacctt aatgatttgg tccctcggtt tgataccggc tttttcagca 1801021 ggtgaacctt taattgggga tacaataagg atttctccgt ctttctcctc tacttgggct 1801081 ccgattcctt caaaagatgc tgaaatcgtc tcgtcgaatg atttcgcttg ctcttgatcc 1801141 atatatgtag aatacggatc atccagtgat tgaatcattc ctttaattgc tccgtctact 1801201 aatttgtcat catctgtttt ttggtaataa tcacttttga tttgctcata cgctttattt 1801261 aatttgtcga acttgctgtc tcctgtgctt gctgattttt ggcccaggat actggaattg 1801321 cccgtaataa ataaagtaag cgccgaagcg acaactgcag tgatcagcac aataaaaaac 1801381 agttttaatt gccgtttcaa ttaaacacca cctttttctt cttacattat tatcatggac 1801441 gaattcttat tcgtcaactc ggagcagaaa tgaaagagaa acgcccttct tttgcttttc 1801501 ataaacctat gtctttatac gacatatgat aaggaaaaag gaggattcga tattgagccg 1801561 atatttagaa atgctgtcct tattcggtgt cgcaggggcg cacccaggcg ggctggcttt 1801621 ttcaaaagcg gtcttgcaaa aggctgcacc ctctccggat cagccgattc ttgatgccgg 1801681 atgcggaaca gggcaaacgg cggcttattt aggacatttg ctgtatcctg taacagtcgt 1801741 tgataaagat cctattatgc ttgagaaagc gaaaaaaaga tttgcgaatg aagggcttgc 1801801 catccctgca tatcaggcgg agctggaaca tctcccgttt tcttctgagt ccttttcctg 1801861 cgtcctgtca gaatcggtcc tcagtttttc acgcctgaca tcctctcttc aagaaatttc 1801921 aagagtttta aaacccagcg ggatgctgat tggtatcgaa gctgctttaa aaaaaccaat 1801981 gccccctgca gaaaagaagc aaatgatgga tttttacgga tttacttgct tacatgaaga 1802041 aagcgaatgg cataaactcc taagatccta tggctttcaa aaaacagaag cgatgtcact 1802101 tcttccggaa gacatggaat ttgaaccaac cacagaaatg gatttatcgc aaacgattga 1802161 tcccatctat tacgatacgc ttcaaacaca ttatcagctc atgcagttat atagtgagta 1802221 catgggtcat tgtattttta tcgcgtacaa gtaaaacggc gtatcgcccc ctgttttcgt 1802281 ccaacctttt tttcctatct atcatatgct gatagaaagt caggatagga ggggaacaat 1802341 attggagaga tattatcatc tttgcaaaaa ccatcaaggt aaagtcgtca gaattacaga 1802401 gagaggcggg agagttcacg tcggcagaat tacccgtgta acaagagaca gagtttttat 1802461 agctccggtc ggcggagggc caagaggttt cggttacgga tattggggcg gttattgggg 1802521 atatggagcg gcttacggga tttccctcgg tttaattgca ggagtggctc tggctggttt 1802581 attcttctgg taagcataga acaaatgcta gattcaccag acacaatgaa gcccgcttat 1802641 ctagtgtaag cgggcttttc attttaaatt ttcttcactt tttcaaagta ctcttcaagc 1802701 gttaaatcat tatcttggat gacctttgcg gcttttttgc ctacatagcg cagatgccat 1802761 ggctcatatt catatttcgt gatatcttct ttatttttcg gatagcgaat aataaagcca 1802821 tatttataag cattgtcctg cacccatttc ccgtctgccg tgcttccgaa cgcttcattt 1802881 agctcaaagc cattgctccg gctcgaaatg tccatcgcaa ggcctgtttg atgctcgctt 1802941 tcacccgggt aagcgaccgc ttcctttgcc ttcctttccc cttttaggct tacttcattg 1803001 tcaaaaatga ctttctgtct gtcatacgaa cggtaccctg agacagctgc cagttcatag 1803061 ccttcctttt tggcagcatc gaacattgtt tttaatgcgt cggccgcttc ttttctgatg 1803121 taacgttttt gaatcttttc ttcaaaagaa aactctacat caggtatgac aagatcgcta 1803181 ggttcatagt ttccgggcag tgcatattgt ttattgacaa gcgcgagtat attttctgga 1803241 ttttgaatgg tttccagacc atcgactttt ttaatatcat tgaaatactg gctttccaat 1803301 gaaaactcac tgttttgagt gtttgatttt ttgctgtcag ctgttttttg ttctgtttgc 1803361 tttgtttctg ctgtggtttt cgtatccttt tgagcatctc cgttcgacat gctgcagccg 1803421 gctccgacta ttgccgttac actcagagcg gcagccagtg agaaccattt accggacttt 1803481 ttcatattac attaccttcc ttttatcaat cgtttccgca tgcataaaga agaggctgcc 1803541 ggcacccagc acgcctcttg atatatttta ttgtgatacg gaatgtaaag ccacttctat 1803601 catatcatga aatgtcgttt gacgctcttc cgctgtcgtt tcttctcctg ttaatacgtg 1803661 atcactcacg gtgagaattg acagggcttt tcttccgtgc ttcgctgcta atgtatacaa 1803721 tgcagttgtt tccatttcaa cgccaagcac accgtatttt gcaagttttt caatttgcga 1803781 atcgtcattg tagaactggt cagctgtaaa tacgcttcct acagtcaccg gcacaccttt 1803841 atcctttgcg gcatcatagg cattttttaa aagctcgaaa tctgcgcaag gcgcaaaatc 1803901 aacgcttccg aaagcaactc tgttcatttg tgaatcagtt gaggaggtca tcgccaaaat 1803961 gacgtctcgc actttgacat ctttacgaat agcgccgcag gaaccgactc ttattagatt 1804021 ttgcacatcg tagctttgaa ttaattcatt cacataaatt gaaatagacg gaactcccat 1804081 tcccgtgcct tgtactgaga tttttttacc tttatatgta cccgtaaatc catacatgcc 1804141 tctgacttca ttgtagcatt ctacattttc aagatacgtt tctgcaataa attttgctct 1804201 gagaggatct cccggcaaaa gcacagtatc cgcaatttgt cctttttcag cacctatatg 1804261 tacactcatc tcatatcctc ctgtaaatct aaattatcat ccagcccgtc cattttacaa 1804321 cgaatgtcat gatgaaacaa acttcagcat tgattataaa ggaatatatc gaaaaaagaa 1804381 atgttcgagg atctgttagg cacttcctca gaaaaacgga taatcggggt gttaatttga 1804441 aaacctaacc gcaggaagga ggggtgggac atgggtaaaa aacatcgtaa ccggatcacc 1804501 ggccaaaaaa agaacaatca tatacctgaa aaagatatca ttgcagctga agaagcacac 1804561 gggaaagaat attccgctgc caaacgcaag ccttaaaact gcagaaaact gcgggtttcc 1804621 gcagttttct tttcattatg tcgtttgtac aatcagacga ttgattttcc tccagccggc 1804681 gggaagcagt tgataatatg ttttcccttt tctgccttca tcaatcagga tcacgtcccc 1804741 tgtggccatg aatcttgcat cataatcact cggaacagtg tcgaatacat taaacaaaga 1804801 gaatgctctt ttcagcacgt cttgatgatc gctcccgttc agttcagttc gatagacggc 1804861 tctgtagccc tttttttcgc caaaccgggg tgtctgaaat attgtcacgt cataggaaca 1804921 agacttcttt ttaaacacgg ataacatcat caagatcccc tcccttttat ttctttaaca 1804981 tattggcgtt tttgctgtgt tttcctctct ctatttttgt cgaaaccgct taatcttttc 1805041 gtcaaaacct tttactagga aaaacagaag caagccgagg ctaaagcctc ctaacacgtc 1805101 tgtcacaaaa tgaaccccca gatacactct gcttatgccg actaaaacag caattacacc 1805161 ggctatgata tataccattt ttttatgctt agacaaaaac gggagatgtt tcactaaaaa 1805221 gtaagcaata acaggataga cacaagcagc attcatggaa tggccgctcg gaaaactgaa 1805281 ggatgattca tgaaccagcg gtgcaaaatc aggcctcact ctttcgatcc attcttttaa 1805341 gactttgttt aacagccgat ctgtgccgaa tactaagagc atcaacaggc cgtcccatgt 1805401 ttttctgtag aaaaacatgc ctgctccaat gatgacaatt agagggagca gaaaagaaga 1805461 agcaccaaga tgcgtgatcc ccgtcatgac ttcattaagc catggctgac ggatcaaaac 1805521 agctgccttg cttattgctt catctgcaga ttgaacagca tttgtatgaa tggccgcagc 1805581 tagaattaaa aagaaaagaa acaaactaac gggcttgtac aattttaacc acctcaattt 1805641 tcacagaagt catagaacat gaataataaa accggagctg accgctccgg ttttaagcct 1805701 cactcatctt catccagctc ttcatctatc atacattttt ctatcaaata atcaaaggta 1805761 atatcagcga tttcaaacag ctcatcctca ctcggtatgt agccccgtct tgcaagctct 1805821 ctgtaaaaaa attcagcgat ttcttccgta tcaatcacaa gatctatttc tttcatctcc 1805881 gtaccgcctc cttttttatg ttttatgaaa aaacaggctg aattataccc ggtgttctaa 1805941 acaattcttt cagtcatata ttgaataaaa aacgagccat gggaggctga cgctatgatt 1806001 gctaaaatga tggaagcact ggacggagaa agatttgata tcataatgga aaaaacgctc 1806061 aaaggaatga cgcgtgtgat gatttggggc tgtctgccat attttttata tgtcttgatc 1806121 cgtatgttca caaattaact gaaatgctct tttaaacttt ccaaaacaaa catcatcatg 1806181 tctttatatt cttcatcctg aaacatttcg tacagaattt tgtagtcatt ataaatatcc 1806241 agaagctcat caacaattga cacagcaagg atgtgaaggg tatcttgatc ttcatcaccg 1806301 ccttcaaact gaagaagagc agacgatgcg atatcttcgc cgatctcatg gccagtttct 1806361 ccgacataat ggacaaacaa cagctgatgc acaaactggt ccatttcata ttttctaagc 1806421 accagcgtga gatcctcttc ctccgtttca agccactctc catcctttaa acgggtcagc 1806481 tcataaatga tatcttccca gccatcttct aaatatctcc aaatttctgt tctatggccg 1806541 ataatgcgaa agagttcttt tccataatct ttaacataaa caacgtcccc aataaggaat 1806601 tcatactcaa tatcaagctt ctccatgtcg acaatgacac cctcataatc tttataaagc 1806661 tgaatagatg attcaaagta taaaacttcg ttatgattga cttcataaag atagtgttta 1806721 tcaatttggt gtacttttgt gatggtgccg actgttccat acataatgac gactacgata 1806781 tcccctactt ggaatttcgg tttattttgc ttcatggtgt ctccccctcg ccgcaacatt 1806841 tctcatacgc tatcgtatgc cgggtgaagc caattcgcat gggcatgaaa accaaaggaa 1806901 atatccaatt atggtatggg tatggacata aaaaaatccg cagtgatctg cggatgaaac 1806961 agctattatc tgccgtgcac ttcagactcg tattgatccc aagcttcatc aaacgtcgcc 1807021 atcgtgtgaa ggtaatcagc attcagctcc aaatatgaac tgatttcatg ataatcggtt 1807081 gatgtttttg gaaagctgtg atcctcatac gcctgattgg caaattcact gatgctgtcc 1807141 ttcggcttag ggtgtctgta tttcaataaa tagtgataaa aggatttcat gggtttcccc 1807201 tcctgatgtc tgtcttttgt tgttctatta tacagttcaa gtgtaaaatt acaacaaaag 1807261 aatactgaaa catgactcag gagaagtcaa aatagttgcg tttcaaaatt ctttctgtct 1807321 ccatgagctg ctgatatgtc aggctttcag gcagtttttt tgtttgaatt aaaagcagct 1807381 gatcctcaat ctctttaacc gtgttttcct cttgataggt cataccgcag gaagaacata 1807441 ccatggcagg ggtgtctgtc agttctatag ccctcgttcc atcagggagc tcccagtaca 1807501 ccgtgttcct gccgggcacc gcttcgagct cgccgcacca ttcgcatgtt ttcatgaaga 1807561 atcccctccg cattcagtct ctttctgttt tttctgctgc gccaaaaatt tcttttcttt 1807621 gagctgatct cttttctcac gccgatcttt taatgtttca tgctccggat ttgcgatgta 1807681 tgcctctctc cttttgattc tgtctacatt ttcaggtgta aacgaaactt ctttgtcagc 1807741 aaaaatggca ctcagcccga tcggctcctt tttgtcagcg gtttcaggga aaacggactc 1807801 aaaataggcg tctgcctgat tggggatata attctctggt tccggatatg acgtaatcac 1807861 accttcaaaa tttcttaaga tcactttgtc aggactttgt gacaggacat agtttggctg 1807921 cagggcgatt ttacctcctc cgcctggtgc gtcaacgaca aaggtaggaa ccgcatagcc 1807981 tgaggtatga cctctcagcc cttcaatgat ctccaaacct ttggaaacag gagctctgaa 1808041 atgccctatt ccttctgaca gatcacattg gtaaatataa taaggacgga ctctgatttt 1808101 taccaagtca tgcatgagct ttttcataat tggaaccgaa tcattaatac ctgctaatac 1808161 gacagcctga tttccgaccg gcactcccgc gttcaccagc ttttcacatg cctcaacgga 1808221 ttcttctgtc atttcgatgc ttgtgttaaa atgggtgttc agccagaccg gatgatattt 1808281 tttcaatatc tcgcacagat gatcggtaat gcgctgcgga aagacgacgg gagctcttgt 1808341 tccgattctg atgacttcca gatgcggaat gctgcgcagc tcttttaaaa tatattctaa 1808401 aatttggtcg ttgatgagca gcccatcacc gcctgaaatt aaacaatcgc ggatttcggg 1808461 tgtttcccgg atataagcaa ttgcagcatc aagctgtttt ttggggacgc ccattccgat 1808521 ttgtccggaa aagcgccttc ttgtgcagta gcggcagtac atggaacatt gattcgtgac 1808581 aagaaacagc acacggtcgg gatagcggtg tgtcagaccg ggtaccggtg aatcttcatc 1808641 ctcatgaagc gggtcttcca gatcgtattt tgttttgtgc atttcttcag aaagcggcac 1808701 agactgcatg cgtaccgggc atctcggatt gtcggggtcc attaaagaag catagtaagg 1808761 tgtaatattt aaggggatcg ttttggtaga aattctgacg ccttcctctt catcctcggt 1808821 cagattaatg actttcttta aatcatctaa cgttcttaca gtgtgtgtca gctgccaaag 1808881 ccaatcgttc catttctctt ccggaacgtc cttccataac tcgatctcct tccaatgccg 1808941 tttcggttta taccatttgt ttttcaaacg aactcctcct cgcgcatatt ttgacttaca 1809001 gttgcttgca ccaaatattc atgttttcaa ggccttcggc tataaagcaa ttattgatca 1809061 gccttccgcc atactgataa cctgaatggt acaacacagc attcatccca aaagacgaag 1809121 cacgggcgag agaaaacaca tgaacgatat cctctccagc catttctttt tctaacgcct 1809181 cgattaaaaa gcttgttaac gaatggccgc gatattccgg cagcacagcg caatcggtta 1809241 tttctgcatg cccaagctct ggattgattt ctgcgcttgc tgcgctgatc aggcggtcat 1809301 gatcaagcat gatataatac accgtatttg cattcatcgt cttttcaata taagcggggt 1809361 caaataccgg ggttgggtac gtgcggaata cttttttata cagcatcgat agctggtaca 1809421 tgtcgtttgt ttctgctttt ctcatcgtaa aaacgggtgt actgtcgttg cgaagacggg 1809481 gcgctgtgcg atatatggct tcgatgatct cctgttcctc tgtataagaa tctgtttgtc 1809541 tccggctttc tgaaaggtaa cgtaccatga cacaagccga atggccgaga taatagccct 1809601 ttagatagcc ctccggcgca aataattgtt tggcaaggat cggctcatca tgctgcttcg 1809661 catagacaat gattttttct gcattctctt cttttgccgc tgccacgata tccggcaggg 1809721 ccttctcaat ggctccgtca taacgaacca ctctgattcg tttattaaag ccgtcatggt 1809781 ccaaaactgc tgtgacaccg ctactcttta ttgacttgag catccgcatc ctccccatct 1809841 gtatgaaggc cgcaccaatc catgacaaaa agtgcaataa ttttagcaga ttctatcatg 1809901 gcttcaacct caatgtattc attggcctga tgagccgttt ttgtttcccc cggcccgaaa 1809961 acgatcactg gtgtatctcc tgcatggtac aaaagccctc catccgttcc ccacggggaa 1810021 gcctcaataa tcggctctgt ctgtttcatt ttttgatagg ctgattgcag cacagaaatt 1810081 aaagggtgat catcaggtaa atcattcggc agccattgag cgccaaacca ttcgacttgt 1810141 acgggatggc gtttaaacca ttcgtcatgg tattctaaat ccttcagcca gttttccaat 1810201 tcaagtttta cagcttctgg tttctcatgg ggagcaattc cgcatctccc ttctatgacg 1810261 acacggtctg caactgaaga tggccaggca ccgcctgaga tggtgccgat attcaccggt 1810321 accggtattg ggatattgtc atacagcgga tctgaaattc tcgcattgcg gactttctcc 1810381 agctcttgta tcgctgtgat aacgtgcatg cttttttcaa tcgcgcttac cccttcatag 1810441 cgtgtgcccc catgtgcgga taatcccttc acagtgatcc gaaaccacat cgaaccctgc 1810501 tgcttaataa atagtttcat attcgtcggt tcaggaatca gcgccccgtc agcacgatag 1810561 cctctcatga tggcggaaag tgtaccggcg ccgccgcact cttcatctac aacactctga 1810621 aacaatacat ctcccttcag tttgacatcg caggcgtgca gggcttctaa agcaaaaaga 1810681 agggctgtat tgcctccctt catatccgtt gagccgcggc cgtatatttt accgttttct 1810741 tcgacagctt gatacggttc atacttccaa tcctttacgc ttccttcagg cacaacatcg 1810801 atatggccgt tcaaaatcag ggacctgcct ccgccggctc ccgttttttt agccacgata 1810861 ttcgggctct catgaaaatc ggatcggtta gatttaaagt agggatgctg ttttaattgc 1810921 tttatgcttg gctcccatac atcaatgtcc atatgaaatt gccgcagctt ttcaagcaca 1810981 acagcttggg cgttaaactc tgaccccaat gtgctttttt ccccaatcag ccttttgaga 1811041 agacgaatgg ctttggccga atgctgatca agccactcga ttacttttct ttcaatgtct 1811101 tgcatcctca ttccccctct taagaaaaag gcatatctat tttgatttca gcttctgtca 1811161 gcctcgtcac ctcatcgatt gtcgagccat tcatcagctc ttttaaaatg aagtgatggc 1811221 tatcgacctc aagaaccgct ttttcggtaa taatcaaatc tacacagcct gcagcagtta 1811281 atggcagcgt acatctttct gttaatttag gccttccctt ttgatctgta tgactcatga 1811341 cgacaaccac ttttttcgct ttttgggcaa gctccatcgc cccgcccata ccaggcacct 1811401 tttttcccgg aacaagccaa tttgccaaat ctcctgattg gctcacctgc agggcgccta 1811461 aaatcgtaat gtcaattttg ccttttctga tcatcgcaaa agacatggtt gtatcaaaat 1811521 aagaagcccc ttttacagcg cggacaggat atcccgcggc gttgcataaa tgcgcatcct 1811581 cttctccctt ttcgggactt tctccaatgc caaggacacc gttttccgct tgaaacatga 1811641 cctgcatgtc aggcttcaaa aagttcggta ccaaggaagg gataccgata ccgagattca 1811701 caatcatgcc ctgcttaatt tcagtagcag cgcgttttgc aatctgttct ctttctgcta 1811761 ctcccaagcc catttccact tcactccctc gcttcgtaca accccctcaa caaaaacccc 1811821 cggtgtgaca atcatttctt cagaaatctc ccccatcgga acgatacgct cagcttcggc 1811881 aaaggttctc ctggcggcca ttgccataag cgggttcata ttgcgcgcgg ttttgtcata 1811941 cgttagattg ccgaattcat ctgcaatgta agcattgatg aaagcaaaat cagcagtcag 1812001 cgcctcttca atcaagtatc gttttcccgc cactgttacg atgtcctttt tttcgcaaac 1812061 catttgatta tcaatgccca cgtcggttaa aataccgcca agccccgctc cgccggcgcg 1812121 aatccgttcc gcaagcgttc cctgaggtga aaattgaacc tctaacgtcc cctctgtcat 1812181 ctgttttccg gctactggat tggaaccgat atgcgaggcg atcagggttt tgacccgttg 1812241 attaacaata agcgggccga ttccgatatc cgggaaaccg gcgtcattgc aaatcacagt 1812301 caaatccgtt acaccgctgt ccaatatcgc ttcaatcaat gaaggaggcg acccgactcc 1812361 cccaaaaccg ccaaacatca gaaccgatcc atcccgaaca tctgcaattg ctgtgtcaat 1812421 gctgattgct ttttgaaatg gcgccattta atgtcaatcc ttttttaagt ttttttcgac 1812481 cgctgcaact gtttctgaaa aaatagagat aagctcttcc atttcaccgt ctgaaatagt 1812541 aaaaggagga gcaataatga cagcatctcc ttctccactg tctattccag ctttggaagg 1812601 ataaacaatc agcccgcgtt ttttcgcctc gctgacaata agctgggtta tcgcctgctc 1812661 tggcggaaac actttcttcg ttttttggtc tgccacaaat tcaatgccta atagcagtcc 1812721 ttttccgcgc acctcaccta taatgccgct ttgagatgcc gcctcatcaa gcttcttctt 1812781 cagcacagcg cccttttttt ctgattgttt gatcaagccg tgctttaaca catatcgcaa 1812841 aacttcaaga gcagctttgg ctgaataggg atgtgcacta tatgtgtgac cgctcataat 1812901 cacacctgac ccttgtttta tggtttcaat aatagaatca gatacgacgg cagcagcaat 1812961 aggtgcatac cccgcaccga gtcccttccc cagtacagca atatcaggta cggtatccca 1813021 atgctctgtc gcgagcatcc ttcctgttct cccaagcccc gtcatcactt catctgcaat 1813081 aaaaagcaca tcgtgtgtgc ggcatacctc acttaatctc tcataatatc ccggaggcgg 1813141 agtaatcgct gctcctgcag caccaataat aggctcagcc acaaagccgg cgatgaattg 1813201 gcttccgatt cttttaatca tggtgtccag ttcatcagct gcagtctgaa caaagtcttc 1813261 ttccgtctcg tgattcagcc gataaatatg tggagctgag atagctggat accgctcaat 1813321 gagatgggtg aaccggtatc tcctttcata aaaaccagac aatgaaagcg ctcccaaagt 1813381 tattccgtgg taactgctcc atcgagacaa aaagatggat ttttgtgttt gctttttttc 1813441 ctgccaatac tgaatggcga ttttcatagc tgtttctatc gcttctgatc cgctgttgac 1813501 aaaaaaagac caattcacat ctccgggcag ctcctgtgcc aagagagcgg ctaattgctc 1813561 ggcgggctca ctcgtaaact gtgagcggta agcaaaagac acctgatcaa gctgttcttt 1813621 cagcttctca gtcacatcac gaactccgtg gccgatatta catgtcaccg cacctgacga 1813681 gccgtcgaga tatttttttc cggtctgatc ataaacatat gaacccttcg cataactgac 1813741 aaccggatag gccgagctaa gctctggctt aatcaaataa ctgctcatgc tcccacctca 1813801 aaaccccttt taccatattg tatgagtgtc caaatggcgg catgacgttc cccgcaaaaa 1813861 ctttttcaca taaaaagagc cttcctaata aggaaggctc ttttgaaatt tcagcatcta 1813921 gcaaataaaa gcggctccaa caataattaa taaaatgaac aagacaacaa ttaacacaaa 1813981 tgtatttgtc ccgcagccaa atccgtaacc gtacccagag tatccataca tgctgttttc 1814041 atcctttctt atcacgatat acgacatttt atgcgggcca agtcccaaat ggtttgtgca 1814101 aacgcctatt tcatgtaagg aaataatgaa atacagtatg cacccgctca tattttttaa 1814161 acgtcagctt ttcgtaaaac tgagttgcac cgtcagtgct tgcagccact aagtaggctg 1814221 cttccattcc tagtgatttg gcgatggaca gcatttcttt cactaagata ctgccgtagc 1814281 ccttcctttg aaactgatct aaaattgcca cttcttcgat tttagccgtt ttctcttgat 1814341 gatcgataaa cagctcgccg cacccaatgg gaactttctg tgcctggtcg ctgtaacaaa 1814401 caacaagaat gattatatct gcttcataga aaggatattt tctttttaat ttttgttcag 1814461 cgattgcttc tccaatataa atggaatcgt aaattttcat aatagaagat ccgtcgctaa 1814521 gactttttgc cgtcccccat gcggttaaag gatgtcccat ctgccccttc cagtcactaa 1814581 gcttcatgtc atatagtagc tcatcctcga cgacaaaacc gctttttaca agtgactgct 1814641 tcaaaccgag cggaaaaaca tgctgcggcg acgcttttaa atggagataa ttcgcatcaa 1814701 gcagctttgg tacggagggt aaaaagttaa gtaaccgctc caatggaaac gtatcatgga 1814761 gctgaacaaa gttatgagaa aaaatttgcg gaagctgcgg atctctgtat acgctgtaat 1814821 gatcaaacga tgccgattca gacgttaaca atatatattg atgttccgtt tttgaataat 1814881 gtcctgtcat gaacgtctcc tttttatgac ctataccttt actctgttgc aatattcaat 1814941 ttctttataa tctcatcgta caccggataa aacggctttc caattggaaa ttgctgaata 1815001 tttcggaaag aagcggagat tggcttctga tgtaaaaaaa acttccttgt tacttgttca 1815061 ctaatcgggt gaaagacgcc gtttagaaac aaaaacggct cgcgttcgat gaaaaacaga 1815121 cgtcggccag gcggattttt gatcaattca gatcgtttcc acgtaatcgg cggcccttcc 1815181 ggaagcgtct ccatctcttc ttttccaatt gtcactatgt cttttctttg aaattgataa 1815241 aattgaaacg catactggtc cacaattcgc cttttttttc cggcttcgat ataaaatatt 1815301 gcaggatggt cagcttcctt tactaaaata taattcggaa tgtttaaaat tttgccaatc 1815361 ctatattgga ataaatatgg gtctggaaca gcgacagtcc gatttagata caaaaaaccc 1815421 cacttttctc caacaggatg ccttacaccc tgatcaaaaa aatacacatt ttgatctgaa 1815481 ccttttacaa aagagccgtc aatcaaatcg gcgggcagaa accgatatgc attttgaaat 1815541 gaatctgggg ttttataggt tgtgtctaat acttcattta tcggcagaaa tggggtaaag 1815601 ttgttgagtc tcgcccaaaa aattgcgtcg ccatgattcc aatgcttcat atcatcatcc 1815661 cagtagcctc caaatttatg gtgaatgaga ttaagtaacg aacggcgatg cataactgag 1815721 caatgatcaa cttgaaaagc ggcctgatca agcactgcat tggcatttct gtagaaatgt 1815781 gagatttcct ctcccctttc gtttacatgt acaacttttt gttttgaata gaccgcctgc 1815841 gcttcaggct tatgtgaaaa ctcttgcacc atacggctca gccgctcagg atgataaaca 1815901 gtgtcgtcag taagatagga aatgtaatcg ccgtctgcaa atgggagcgc actgttaatt 1815961 aatgtggcat aacgggctgt ttttaatcga tctgcaggat gcacgaaact gttatgatat 1816021 tgaatgcgcc ggtcatggag atacttgtga atcaccgcag ttgtttctgc attcgaatga 1816081 tcatccatga taaaaagctc ccaaagatca tgcgtttgct gtatcacgct ttcgatcgct 1816141 ttttgcaaat aatcgggttt gttgtaactt gttaaaataa tagacacttt ctctcccatc 1816201 tataccgcct cccgccgtca aacataaaaa cggctccgca gcaagcagag cctctgtcat 1816261 catttaaaaa gcaccccagc ttacaacact tgagagtgaa acatgagatc tcgtgttatt 1816321 taacgggttt tggaaaataa ccaaatcagt cagaacttct tttacgatga cattttgaag 1816381 tgtatctccg ttgatcaaat tgacttttga aaccggtacg cccagctctt ttgcaaaaac 1816441 aagctggcgt ctgaggtcag atggatttcc ttcagaagac gattgacgta tcagcagaat 1816501 cagcaaaagc aaaataaaat gcagatcatc ttggttttct tctcgatcca cttgtttctc 1816561 taaatccaaa tcatccctct cccttatcct tatctctgtt tcacaatatg tgcgacttcg 1816621 atttatggta taggctatgt ccactccatt aaaaaatcag cattttcctt aaatagatga 1816681 aaaatagatc aggtacggcg ttcgactcat accaaataac agccggaaga atatgaataa 1816741 cgtgagttca ctatcgaata ggaggtgtgt gtaatgagct ctgaaaatgc acagttaaaa 1816801 aaggatttaa ttaaagccgt tttaagccct ttatttccaa ctgcaacaga aggaggagaa 1816861 aatatggata gtaatcttaa agccttgctt gatgctgcca tcgatcaaaa agtagatgaa 1816921 agtgaaacgg ttacggcaga atctatttta gacccttctc ttccggcaag atggattttt 1816981 gccagaatta cgccaggcac tacaatcagc attgtgactg attcaggtga catgatcgga 1817041 ccggttgttt tcgttgcttt cgatcaggtt cacgggatcg tatttgtaac acaggaaagc 1817101 tccgtcactc cggcaggcca agctacaaca ttaattgatg tagacaaagt agaaagcgtt 1817161 acgttctttt cataacatcc gatgaaagtc ttgtatatcc agtcgggata cggaggaata 1817221 tacagttatt ttgatcgctg ggctgaagaa tgttttcaga acactcatac agagtatatg 1817281 attgcagata aacctgaagc agaatctttg atgaagatcg aagcgtttca gccggatttc 1817341 acacttatga tggttggaga ccgcgttcct cacgactggc tgacctggtt aaagggtaag 1817401 gatatccccg tgtatgtttg gctgaccgaa gacccatttt atatggatat cagccttcag 1817461 gtaattaagc ttgctgacgc catattaacg atagaacaaa atgcagctct ctactatcaa 1817521 gagctcggct accagaacgt ctattatgtt ccgataccag ttaaccatcg gctgtttaaa 1817581 aaaatgggca ccgaacattc ctatcattca aatctgttaa tcatcggcta tccttaccct 1817641 aatcgggttc agcttatgaa agaagcggtc catctgccat tcacggttcg ggtaatcggc 1817701 aaggaatggg gaaaatatct gcctaaaaaa gtgctcaaac agccgcatat tgatgtcgtc 1817761 agcacatggg ttccacccga acaggccgtt cattattata atggggcaga catcgtaatt 1817821 aatgcgcatc gtccctatca ttttgctttc aaccaaaata ctatgcgcat caaaaatgcc 1817881 agttttaata accgaacgtt tgatatcgct gcatgcgaag catttcaatt aacagattta 1817941 cccgcggcgc atcctttttc atccattatt tcttatcacg gcatgaacga ctttaaggaa 1818001 aaagccgctt tctatatcaa ccaccctgaa gaacggcaaa aagctgcagc agccaattat 1818061 aaagagaccg tacccgcatt tacgtttgat gagcttcctg caaaactaaa agcgattcat 1818121 ctggcgcttt cttgaaaaat cgttcattgc tatgaacgat ttttttattc atagaaaaaa 1818181 gcagctgcac aagctgcttt ctattctagc cgtcagaacg gtctttcagc ttcctcggat 1818241 ttacctgttt atgaagatca ggcatttcgc cgagatgctg tgcaatttgt tcccacgata 1818301 caattttgaa attttgattg acggcttgtc cgttatcaat attttcgccg tcctgcgcca 1818361 caaaaatccc gtacggatat tttgggccaa gtccgaaacc gagaacatca ataccatccg 1818421 tgtcactagt accgtctatc ttctcgccat ctgtaatctc aaagttggct acatagcgat 1818481 ttttcccctg ccgttcatac attgcatagc tgttatttcc ttgacttgaa gccatgagat 1818541 atcctttgcc atttggtgca taatagattg tcagtccttc aatatcagct gtcaaatgat 1818601 ctcctgtcgc acggtcaaca acctgcccct ttgaccctcc gccgggctca gcgttaaatt 1818661 tccagatggc ctcatcttcc tctgctatgt ataggtttcc gtactcatca tccgcaacaa 1818721 ggccttcggt ctgagaattc aacttaaatt cacgcacctt tttccctgtt acataaccct 1818781 ttccaccatc aacaatttca tactgctcaa attccccttg tttgcctgtc actaatgcgt 1818841 aaaatgctcc tgttttctgg ctgtgataca agctgaatcc ataaacctca gaaatattgg 1818901 tggaaatagg atggttcgga tctgtaatgc ttttcaattt tcctttatcc ccgtctattg 1818961 catatacttc aattgtattt tttccttcgg accggttgga tgcggcagca atatcaattt 1819021 tttcgccgtt caatggaaaa tcatagcgca gatcgacatt attgagcttg ccaaactcat 1819081 aagaatgaag ctgttttccg tctaaatcat acacaacgag ccctgacttc ttatttgttg 1819141 taatcaactt gcttttttcc gggtgttttt catgaaccca aatggccggg tcatctgctg 1819201 catcatcgcc agatgcgacc ggatctgtct ccgtgtgtgc agtcactttg aaatgatgtt 1819261 cctcattcac ataatgagcc gacaccgagg ttgctgtcag gctaagcaat aaacccgcgg 1819321 cagtgcttag cagcattgtt tttggaacct tcatttggta ccctcctctt ttatcactaa 1819381 cactactatt gtaaaatata tacaggtgat taccgtgagg aaaatgaacc tttttttata 1819441 gggtttctga ctcataaaca acttattccc caaagaggtg gtgagatgac tttgccagat 1819501 ttacttttgc ggagcgaaat aaaaatatgt tgaatattta gtacattatt tatttagttt 1819561 tgtttttccc tagttacgtc cgtttttcca ttttctatta aaaaagaaca ctttgtgaca 1819621 tgatcattcc cctaaatttt gttttattgg ttgctttcat taattcgatt acaaagttga 1819681 acatatgatg catggtagag aaacgagagt tggaggataa gccatgccta aacagcaaac 1819741 agcagaacta aaaccatttt tccataacaa aacagtttta gtcactggcg gaacgggttc 1819801 aatcgggagt caaattgtca aacgcctttt gatgcttaca cctaaacagg tgattgtatt 1819861 cagcaaagac gacagtaaac agtatgtcat gagccaaaag tatgcggagg ataagcggct 1819921 attatttgta cttggagatg tacgcgatca cagaagggtg aatcaggtga tgaaaggcgt 1819981 cgatatcgtc tttcacgcgg ctgcgctgaa acaggttccg acatgtgagg accatccatt 1820041 tgaagcgatc cagaccaatc tcatcggcgg acaaaatgtg gtggaagctg ccctttcaca 1820101 ccgagtgcag catgtcatta atatcagtac agataaagct gtatctcctg tgaacacaat 1820161 gggtgccacc aagctgttat ctgaaaagct gtttcatcaa gcaaaccgcc acgtccaaaa 1820221 caaaggaacc ttgttttgtt cggtccgctt tggaaatgtt ctcggttcca gaggttcggt 1820281 catccccata ttatttgaac agatgatgga gggtgaacct ctgaccatca cagacaaaaa 1820341 catgaccaga tttttcatgt caatagacga tgcagctaca ttgacattac aatcggctgc 1820401 tattacaaaa ggcggagaaa cctttatttt caaaatggaa tcactgaaac ttgaagaact 1820461 gattcatggg tttgaagaat atgcatcgca gcacgggctc ccgcggccgg ctgcagtaga 1820521 agtgggcaag cgtccaggtg aaaagcttca cgaagaatta acatctccac atgaaattga 1820581 atcactgtat gaatggggca acctttatgc gatccttcca gagccggaaa aacatcctga 1820641 ctttcgcaaa gtcaatctgc ctgggtatca atcagatcaa gccccgctca ttacgaaaga 1820701 aagaattgct cagattattg aagaattgca tcaagagaaa aaggcataaa aacaagcctg 1820761 tctatccatt aggcaggcct gtttttaaca gtttatttat taaagagatg cagatagctt 1820821 tcgtatcctt cttcttttag cttatgcttc ggaacaaacc gcagcgctgc tgaatttatg 1820881 cagtaacgaa gtccgtttgg ccccggtccg tcattaaata cgtggccaag atgagaatca 1820941 gcagttcggc ttcttacttc tgtgcgaatc atgccgtggc tcgtgtccag tttttcttcc 1821001 acttcttctt caatcggctt tgtaaagctt ggccagccgc attgggaatc aaatttatct 1821061 ttggatgtaa acaatggctt gcctgacaca atgtctacat acaacccttc ttccttatga 1821121 tcccaatatt cattttgaaa tggcggctcc gtgccgttat tttgcgttac ttcatattgc 1821181 atgcgattta atgactttat tttttcttct ttattgtacg ccatttattt agccccccaa 1821241 tgctcgctga taaatcccgc tcgtccggaa cctgtccggt agcgctgata atgtgctgga 1821301 ttctttttat aaaaatgctg atggtagcct tccgcttcat agaaaggttc agcttttaaa 1821361 atgtccgtta caatcggatc tttaaagatg ccgctttccg ccagacgttg cttggaagct 1821421 tccgcaagct ccttttgttt atcattatga taaaaaatgg ctgcgcgata ggaactgccg 1821481 cgatcagcaa attgccctcc ggcatctgtc ggatcgattt gctgccaaaa taattcaagc 1821541 agtttttcat aagggaatac atcaggatga aacgtgattt gaacggcttc acgatgtccc 1821601 gtcgtttcac tgcacacctc ttcgtacgta gggttttcag tatggccgcc tgtatacccg 1821661 gacaccactt tttcaattcc cggctgttcg tcaaaaggtt taaccataca ccaaaaacag 1821721 cctcctgcaa atgtggcgat ttcttttttt tcagacatac tggtgcctcc tttgttaata 1821781 cgtggtatta ttatattata gcatgtaaaa atagaatgaa aatgattctg cttttcaata 1821841 aaatctatag gttttaagca atatgcttat gtaatggagg ttcacaaatt tgaaagtaag 1821901 aacacagatg atgtacgata tggaaacttt actccgtaaa gtctttaaac aaatacgcaa 1821961 tgaaatcaat gaaattttag ataaagagct gtcgcggaat gaattcacca ttcttcgaat 1822021 ccttagtgaa caagggccta aaaaagtcac tgaatttgcg cctattttag aggtatcggc 1822081 aagccacatt acggctgtga ccgatgcgct ggtagaaaag gaatggatta cgagaatcag 1822141 atcgaaggaa gacagacgca tcatccgcat tcatatcact gaagcgggcg aaaaagtcct 1822201 tcagcacttt aacgagaaaa aaacggaata tttctttaaa cgctttgact gctacactga 1822261 tgctgaactt gccacgttaa tcgagctctt cagcaaactt gataaaaaac ggtgaaaaaa 1822321 agcacatacc gatatatagg tatgtgcttt tcgcagtgct tcacttattt ttcagtaaac 1822381 agcttcattg ctttccagcg gccatatcta taatacaaaa atgccgcgca gctgctaaat 1822441 aaaaaactca ttccgattcc aagcccgatt cctttttgtc caagccaagc tgaaaataga 1822501 gctgtgaaag gatacctcaa cacccaaaac gagatcaaat ttaataccag aacctgcagc 1822561 atcgctcccg cggccctgac gattccgttc agcacaaaat taaccccaat aaaagggtag 1822621 aaaaacgcga tccacttcaa atattgttca ccaaatgcga ccgcatcagg ctcactgata 1822681 aataacctta tgaggtattt accaaatacc caaatcataa ccgcaatcac cagcatgcag 1822741 gaaataacag ctatcacacc tagccttgca attgttccca ctcttttttc gtttccgatt 1822801 ccaatatttt gccctgccat actattgacg gccgtaccgg cagccattgc tggaagcgtg 1822861 atgatgctat caagccgctg caccgcgcca aagcctgata ccacgtgatc cccgtatgag 1822921 ttaacaacac tcataatcgc catcataccg cctgtaatca ccatcatctg cagacctgcc 1822981 ggaatcccga gtttcaaaat cagcgcggac tcttcccact tgggcattct cggaatcgag 1823041 aatggcacaa gcttgtgttt gatgacataa aacaacccat acaaaaacgc aatgccctgt 1823101 gacaaaatcg ttgaataagc cgctcccgct attcccatgc ggaacacaga aataaagagc 1823161 ggcgcaagca ctgtattcag tacaacagca aacgcaataa accggagagg tgtcttgctg 1823221 tcgcccagcg cacgaagcac agtactgata aagttataac caaacaaaaa taaaatgccg 1823281 ataaattgaa tctgtaaata cgtctcagca agcggtatca ttgactccgg cgtttttaga 1823341 agacgcagca aaagctctga gagaaaaaaa ccggccgcgc cgaatccgat gcttaggcct 1823401 gttaataaaa caacaaaagc gttaatatac gacgccattc cttttatatc atcttttcct 1823461 ttttgctgag ataaaatggt taacgtcgca ttgttaaggc ccaaaataaa agacagcacg 1823521 gtcaaaacaa tcgtgcttga taccgcggct gccccaaggg cctttgcccc cagtaaattg 1823581 ccgatccaca agctgtctat aaattgaaag gaaacctgca atgcgtttcc gagcataata 1823641 ggcattgaaa acagtacaag ctgtttcagc acgttcccct gtgtaaaatc gtatgctttc 1823701 atcttttctc cttgtgttct caaattttct tcggaccaca cgaaaaaaga gacgttgttt 1823761 catgtctctt ttttcatgac ttatcggttt tttttcggtc tcgcataccg aatgtaaaca 1823821 ccatcacact taggaacaag gcacaatagg aaacattcaa atacatttga tccatatctt 1823881 cagcagccag atgatgataa gcaagccagc cgaagtacag ggaaaatgta aaggataata 1823941 aactgaaata ctggtaaatc cgtttcattt tcagtcacct ctattgttta ggatggtaat 1824001 aggaaaactc aatttcatct ttttctaaat ttatcttatc cgctttgaca tacattccat 1824061 tcgttaaagg catttctgac aaacgcactt caatgctttt atctccgggg tgaacatgga 1824121 caaatgacgg caattcataa aagctgtcca tataatttaa cacaaagcta attggtatac 1824181 tcaatttccc taacgaaaat ttcgtgacat tcagctctac atcaccgttt tttttcacgg 1824241 tcggctcaaa agcgataaac gcatcaatag acgtggaaaa tgccttgatt ttccctgcga 1824301 catgaacatc atcatcaatc tctactttat aatcaagctt gtttgatgct ttgtcgttta 1824361 aatatgagtt aacaaacgca gctaatgatt cttttgtgct tgtcacttga aatccatact 1824421 cgctctcaga tgcatctttc acctgagcct gttcccccgg aagcaaaaca agtgccacaa 1824481 acccggcggc gaggataaaa ttgattgcaa gcaatataaa aaacagtcgc ttccacttat 1824541 tcatgctgtc accctactct ttcggtaatc cttctttttt aatggcttga tagacgcgct 1824601 ttgcgataag agaataaccc gtaccattag gatgaaaatc atcttcctca gaaattcggc 1824661 tgctgtcact tttttgatta aacaaatctt cgatatggac gatttttgca tgtttatctt 1824721 ttttcagctc tttttcagca atatggttcc aatccgtgac gacaccattt atttcattta 1824781 gttctgataa tgtaaacgta aacggattgt acatgctgac ataaatcagc tcagcgtgat 1824841 cattcagctc gcgaatttca gaaatgattt tttcaaagcg cttttcgtac ggtttttccg 1824901 cttcctgaaa cggttcaacg gttaattgca gaaagttttg gcgaaggatt ttcatcaaat 1824961 cattaccgcc aattgtaaaa aagacataat ctgcgtcctt tatgcctttt tgaacctttt 1825021 tatcttttag tttttctaat aaatcatccg aacggttccc ttttacagca taatttttca 1825081 cgtcgaccgt tttgacttgt ttatctgacc ggatagaatc cgccaccttg ccgacatatc 1825141 cctttccgtc gggatctccg actccttctg tcagcgaatc tccgacagcc gctatgacaa 1825201 tgtgttcttt tgttttcgtt tcatgggctt tttgttttcc ctcagatgat gtacgtatgc 1825261 tcgtacacgc agtaagaagc aaaatcaaac tggccatgat tgaaaaaatg cgcagcttca 1825321 atcttgttgc tccttcccat tctactagtg gaaagtgtat catgttttag aagatttgca 1825381 aatgcctagt ctcttagctt acttgagtgt actggctgac ttcacatcgg aaatgatatc 1825441 atcgtacggt gtattctcca ctccattgta atctttcagc accttaccgt ccggacctac 1825501 caaataaaaa gaagattgat gaatcacttg gtcctctccc tccggcttct ttacgatcgc 1825561 tttaaagctc ttaagtgcga actcctcaat ctcactctgg ctgtatcccg tgagaaaatc 1825621 ccagttatca aaagataatg gataatttgc ggcaaatttc ttcagctgtt tcggcttatc 1825681 gttttctgga tcaacactaa atgatatgat gcggacatct atattttcgg ctttcagttt 1825741 tttttgcaga tcggtcatat gagcggtcat tggcggacat atagtttcac aattggtaaa 1825801 aataaaatcc gccagccata cttctccttt taaactctct aaagaaacgt tcttgccgtc 1825861 ttggttttga aatgtaaaag gctccacctc gtaattgagc ggatctttaa tctgctgtcc 1825921 tccgcatgca cacaaaaaca gaaaaatcag cccagccgtt aaccccttga taaccttcat 1825981 gacatccatc ctttccagcc agcataaaaa cgctttctaa aaccgtcctt actgtcccat 1826041 gtttgtattc gatactgagc aaaaaaaatc ctgcatgcct ccccattaac gattacaaag 1826101 gagggcatgc aggtaaaaaa cggcatgtta cgcgttgtgc tttaacacct cttgatgaaa 1826161 tacagcctga taatctgccc acttcatccg ccgcttcata taatgtcgga aagaatacac 1826221 ttttgccctg ctgtttgatg aaaacacttc ttttaagtag aattgcaaat ggtgatgtaa 1826281 cataaagaaa tagtgctcat cttcctttaa tacaggtatt tctgtcactt tcacctgaat 1826341 cccgtcaccg cgtttgaact ctaggctttt gagtaacaag ctatcaatcc tcttttttgt 1826401 ttttcttcta ttatatatga tgccagccgg gctgtctgtc attttgcgcg gttgtgtaaa 1826461 aaaattagat tagcaaatgg aacaagtcct catccttgtt cacctctaca taatgaaacg 1826521 gttttttgtt catccgttca atcagcggcc cataatcggc tttgttctgc agctcgatgc 1826581 cgacaagagc aggtccattg cttttattat ttttcttcgt atattcaaac cttgtaatgt 1826641 catcattcgg cccgaggact tcgtcaagaa attcgcggag cgcccccgct ctttgtggaa 1826701 aattgacgat aaaataatgc tgaaggcctt caaaaatcaa ggaacgctcc ttcatttcct 1826761 gcattcttcc gatatcgtta ttgcccccgc ttaccacaca caccacgttt ttccctttaa 1826821 tttgatcctt gtacaaatca agcgctgcga cagaaagagc tccagccggt tcagcaacaa 1826881 ccgcacattc gttatataat tcaagaatgg atgtacatac ttttccttca ggcacaagga 1826941 gaatgtcatc aacgacagtt tccagcgtcc ggaaggtttc ctcgccaatt tttttaacag 1827001 ccgccccatc tacaaactta tcaattttat caagtgtgac gacatgccca gctttgtttg 1827061 attcaaagta ggatgccgct cccgccggct caacagcaat tacctttgta tcaggagaca 1827121 cgtttttcaa atatgtacct accccagaga gaaggccgcc gcctccgaca cttgcaaaaa 1827181 gaaaatgcgg ttctgtatca atgtcgttta aaatctcgac tgcgagcgtt ccctgtccgg 1827241 ccatcacatc cggatcatcg aacggatgga taaacgtccg agattccgcc tcacagcatt 1827301 cagcagcgct tttatacgcg tcgtcaaacg tatcgcctgt caaaataata tcgataaatc 1827361 cttttccgaa tagttcaact tgagatactt tttgtctcgg tgtagtagac ggcataaaaa 1827421 ttttcccgtg aatgccaaga tgtttacacg aaaatgccac accttgagcg tggtttccgg 1827481 cacttgcaca cacaactccg ttctctgtct gctcgctgga aagctgtttc attttatgat 1827541 aagcccctct gagcttaaaa gatctgacaa cttgcaagtc ttcgcgtttt aaatagatat 1827601 tgcattcata tctctcagaa agtctgtcat tcctctgcaa aggtgtgtga atgacaacgt 1827661 cctttacgtt ttggtgagcc ttcaaaatgt ctttcacttg gatgagagag ttttctttaa 1827721 gcaacggttt catgtacaga ttcctttctt gttttaaatc cctatttaat atgccattat 1827781 aacatgaata ttcaaaaaat aagacaatta tttttattta ataattaaaa aaatacagac 1827841 tatgtccacc acatcttgtg gtaacttctg ttcaaccatt atcctgcaga gccaagaaaa 1827901 aagatgatcg taaaataaag ggtgttttca accaaaaggc atgatataat gaaaccaatt 1827961 agaaccaaaa ggagccaatt gatgaatagt gcaccaaaac tcaatacatt tcaacatcta 1828021 atcggagaac atcaaacttt tctggaagcg aagcgaatcg ccaagcagtt ctcgttatcg 1828081 gagcttcctg tcttaataac aggaaaaatc ggaacaggca aaaatcactt cgcacatgcc 1828141 atacacttgg aatcttcgag aagcaatgaa ccgtttataa gcgtcaattg cagcacccat 1828201 tcggaagaaa cccttattca tgagcttttt ggccctaacg gaaacacagg tgtttttcaa 1828261 aaagcggtac gaggaaccct ttttcttgat gatgtatggc gcatgcctgc ttctgtacaa 1828321 gctcagctgt taaaagcgct tgattcagac acggagaaac cgcgaatgat ctgtgcttct 1828381 gcagaccgat ccgtggaaca tacattcagg caagacttat tctacagact gaacatttta 1828441 acgctcacac tgcccgaatt atcggaacga aaaagcgata ttccgctttt gacacagcat 1828501 tttctctcaa attctggtca gcaattgtta atcgatccct ccgtttttcc cgtgcttgag 1828561 aagcatgcat ttgaaggcaa tgtcagggaa ttaaaaaacg ctgcagatta tatggcggca 1828621 gtatcaagcg ggggaacgat tcagccatat gacctgccgc cgtatattag aggcacgata 1828681 gacggaaaaa cgtcgaagaa aaaagcgaaa ctgcttactt taatggaaaa agctgagttt 1828741 ttgtttattt tggaaacaat aaaagtattg aacgaaaaag gagaacctgc cagcagacgg 1828801 atcatttctg aacacagcaa aaatacccaa acctcgttaa ctcctcagca ggtcagaagc 1828861 cgtctcgact atttggagaa aaaagattat gtcaccaaaa gccgcggacg cgcaggcaca 1828921 aaaattacct ttgagggctt gagctttata gagacgttaa aaaatcaaat gatctagcga 1828981 tcgaaaggag aatgtacttg tttacaatca aagaagagat cgccaatgcg attacacacg 1829041 gcatcggtgt cctcttatcc atcccagcat tagtgtttct aatcatattt gcggctaatt 1829101 acgggtctgc atgggacatt gtcagcttta caatattcgg tgtctctatg ctgctgttat 1829161 atttgagctc caccctgctt cacagcatca cacataaaaa aacgaaggac attttggaga 1829221 ttattgatca tagcgcaatt tacgtactca tcgccggaac ctacacgcct tttttgcttg 1829281 ggccgctgaa aggcacactc ggctttaccc tgttggttat cgtatggtca cttgccctag 1829341 gcggaatcgt ttttaaaatt ttctttgtga aacggtttat cctattgtca accttcgtgt 1829401 atttagtcat ggggtggctg atgattattg cagttaaacc tttatatgct tcactgagcg 1829461 gagcgggatt cagcctcctt tttctcggcg gcattttata ctctgtcgga accatctttt 1829521 acatttggaa aaagatcccc ttccatcacg ccatttggca cagctttgta ttgggcggga 1829581 gcgctgccat gtttttctgc gtgctcttct attgtgtaaa ggtgcctttc ctttcgtaac 1829641 agtaacagaa aagcgcagtc ttcacgactg cgctttttta tgcacgtaat tgtttttcat 1829701 tggcaggtat ataagctttt gaaaaggaca attcaatgtc tgccggtttt aagcgtttaa 1829761 aaaacgagcc attttgcatg ttatctgttc ctttcgtttc caccatcacc aacggaagat 1829821 gatagcgggc cgcaagttct acaggatcaa tagaaccatc tagtgaaaga atcaggcttt 1829881 gtcccttttc cagctgtttt gtcacatctt catatacctt ttctgaatcc ccgtctgaaa 1829941 tcacatccat ccgatccagc cattgcccga taaaaggcaa gcggaacact tttgggttag 1830001 cgataaagcc ggccggttcc tcaatatatc cagcaattaa ggccagttca gccaaacgca 1830061 aacggggatg cacatacaaa acaggaccgt gtggtattgg ctctggctga tggatcgtca 1830121 caactgaacc ggagatgccg atacagcctt ctaaaaacgc ctttggctgt tcgtacacaa 1830181 gagccatctg ttttttgtat gacagacggg gatcgagcat tgtttgatta aataattgtt 1830241 tcatattttt taacagcata tacacaatat aaaccactag aaggctgtag cgaaccaatt 1830301 aaaatcctcc cgctttagaa gaattctttt tttcatacat tagaaattcg taatcatacg 1830361 ggtttttttc gtctttggtc ccctgctcag aagaaaccag cttccaattg gattcatcaa 1830421 attcaggaaa gtgacggtca ccctcaaact cgtgatgaat tttcgtcata tacagtctgt 1830481 ccgcataagg gaacaggtcc gtatagagct gagcccctcc gatcacaaag cattcttcag 1830541 ggcctgaaca aatgtccagt acatccttta atgaactgac aaccgtgcat ccctgaaatt 1830601 ctgaatccgg cgctgaggta acgacaatat ttttccgatt tggaagcgga cgtccgatcg 1830661 attcaaatgt tttccggccc ataatgattg aatggcccga tgttattttc ttaaagtatg 1830721 caagatcatt gggcaaatgc cacggcaaat cattgtcttt gccgataagc ctgttggcat 1830781 ccatcgcaaa aatgaatgaa atcatacgct gaccgcccct tttatatgag gatgcggatc 1830841 ataatcctcg atgataaagt cctcaaatgc aaagttaaaa atagaatcaa cctttctggc 1830901 gaaacgaagc tgcggaagcg gtctaacatc tctttccagc tgcaaattga cttgttcaat 1830961 atgattttgg taaatatgaa catcaccaaa cgtatggatg aactcgcccg gttcaagccc 1831021 agtcacatga gcaatgatca tggttaggag ggcataagat gcaatattaa acggcacacc 1831081 taagaaaaca tcggcagagc gctgatacag ctgacaggac agcttgccgt cagacacata 1831141 gaattggaac aggcaatggc acggcggcaa cgccatttta tcaatttcac caacattcca 1831201 ggcgctgacg attaagcgtc tggagttcgg atttgtttta atatcttcaa taagacggga 1831261 aatttgatca atggtttctc catcagctcc ccgccaagaa cgccattggg agccatatac 1831321 aggtccaagt tcaccgtttt catcagccca ctcattccag attcgcactc cgttttcctg 1831381 cagatagcgt acattcgtat ctccttttaa gaaccacagc agttcatgcg caattgattt 1831441 aaagtggagt tttttagtgg tgagcatcgg aaagccttcc cgtaaattaa atctcatttg 1831501 atatccgaaa gtgctgattg ttccggtccc agtccggtct ccctttttct caccatgctc 1831561 taaaacatgt ctgcagaaat ccttatactg tttcattttt ttcatccttt aaaagtagtc 1831621 ttctagtagt gtaacacaat aaaaaatcat ttctgaaccc agaaatgatt tttttatagt 1831681 cagctgacga caggcttttc atcctgttct ttttcttcat cttgcagatc ctgatgcgta 1831741 tgtgcaattc tgctcgccgc tgctgcagca agagctgcca caatatcatc caaaaaggtg 1831801 tgaataccgt ctggactttc atcaagttcc ttaataattc caatcttctc tttatccaaa 1831861 taaccgaaat tggtcaaacc gatcgacccg tacacattaa cgattgaaag cgggataatt 1831921 tcatctatgc cgtaaagcgg ttcatccgtt tcaacaaggt gctgcagcgg ttcggggaga 1831981 agtttctgtt ctgcaagctg atcgagtgca aggcctgtca aaacagcatg aataatttca 1832041 cgtttgttca ggactttttc tacattctcc atgcaaacac tgagcggcag atttggattg 1832101 tatttttcct gaagtttttg aacaatccgt gcaatatctt ctatcataac gccccgtttg 1832161 ttcagcatat cctttgttat atcgaccatt tcattcattg tgtacttttt catgtctaat 1832221 ggcatctcct ttaggcactc atccagttgg gaggcgtgtt gcggtcccag taaatgctcc 1832281 caagctcatg atgtgattga aatccatctt ctgctgtatg ataatgaaaa ttaaaccagt 1832341 agccgtcatg aggcgggtgg tctcttcgca catggaatct gagaagatct tctccagttg 1832401 tccgattgta aacgttgaaa attttttccg ttttgcccgc tgaaggcatg cttgagatca 1832461 caacatcttg gtacgcctca tcatcttgca atgtcgctaa ataatcacta atcacatttt 1832521 cgatttttgg caggatctct ttccgatagt catcctcaat gacaggagcg attctgctgc 1832581 cgaattttaa aaaggactga tcctcagcgc tgtcaaggag ctgttccttg tacgattgaa 1832641 aaagcagttc aggatctcgc ctgtcatccg actcatcatc gtacaggtca tgctcatcat 1832701 aaaaagcggt gtaatcattc tgctcaagac tgctcggctg tccggaaggc ttgtccgcca 1832761 taagggcagc cggaggagat acgagcccga acgttacaat ggtaaataaa accacaaggg 1832821 tctttctcat ccacaatttc atgactgctt attcctctct attttattgt catgtttctc 1832881 ttattttagc acatccaaaa catgcaagtc atgtactata tgaaactgat atgcaaatta 1832941 ggagattcgt tgctatgcac tttgtgtaaa aacgcttaca atatttcatg aaaggaggct 1833001 ttccgcatga ttgacgctct gtttgccaca gtttcactct taacattatt atactttgtc 1833061 gtcatggagg tcaccgatta acagaaagcc cgtgatatga atcacgggct tgtttgaatg 1833121 acgccataat ggaacagtgc tgtttttctt ttcatgacgt taaaaccaaa ctgttcaaac 1833181 cgcgggcttt tccagtggtc ttttagcaca acgctttttc tggcgactcg taccgcttca 1833241 ttgatacatc cttcgtgcaa aacggaatcc tctgccaaat cacgtaaagg cgcgatgccg 1833301 tcagaggttt ctacaggttc atgaaacatt ggatcgaaat aaaccacatc aacagagttg 1833361 tcagggagct gcttgatgtg ttcaaagcaa tcaccattct tcacctggat tcttctcatc 1833421 gcagcttgaa gctcttctat acccgtttcc catgaatgca gccccgtcct cactaaaaca 1833481 gacacaagat ggtttttttc aatcccaaca acagaacccg tttcgcctac tgccatactt 1833541 gcgataatgg catctgaccc caacccgagt gtgcaatcta aaaacgtatc cccttcagat 1833601 aagccggcag cccgaagcat aggttctttc tccccctgta agaagcgttt ggctctgaac 1833661 atcgctgtat tcggatgaaa aaagaatttg gcaccttgtt tcgtatacag ctcaaaccgc 1833721 tctttgccga ccacaagcaa atcacgttca gctgatttca gcaggtgctc aaccgtttgt 1833781 ttattccggc cgcagtatgg catatttagc tctttagaaa gctgctttgc agtttttatg 1833841 gtgtgttcag acggtctata gcttgttgtt atcatcttct gtactcccaa aaagaaaatg 1833901 cccggagaac gggcatttag cagtgcgcat cgaaggcagc agtcagattt ttcatgattt 1833961 cttccatatc gtgtccttca atttcatgac gcggaataaa atgtacgact tctttgcctt 1834021 tcaaaagagc cattgatggt gaagaaggct cctggccagt aaaatactca cgcattttcg 1834081 cagtagcttc tttatcttgg cccgcaaata cagtcaccgt attgtcaggt gttttgtcat 1834141 tctggaggac tgcctgtgta gccgcaggac gcgcaaggcc tgccgcgcag ccgcatacag 1834201 agttaacgac tacaagagtt gtgccctctg ccttttccat aaagttttct acttcttccg 1834261 ctgttgttaa ctcttcaaaa cctgctccag tcagctcgcg gcgcatcggt acgacaagct 1834321 ggcgcatgta ttcttcataa gccattgaca taaaaaaagc cccctctagt atccttcatc 1834381 tgaagtaaag gatactatag agagggccgg atttcaaatg ttcacgcctt aaaataaaag 1834441 aaagtgtccc cagctatcta gattttcata ataccgccgg tgttggcact tgtcacaagt 1834501 ttagaataac gtgccaggta gccggttttc actttcggtt caaaaccttt ccagttcgct 1834561 tttcgttttt cccactcttc ttctggcact tgtacatcca agatgcgttt ttcaatatca 1834621 acgataatat ggtctccgtt ttcaacaaag gcaagcggcc cgccctcagc ggcctcaggt 1834681 gatacgtggc cgattgagag gccacgggag gctccggaaa aacgtccgtc cgtaatcaat 1834741 gccacttttg gcccgagtcc cattccaacg atttgggatg ttggcgccag catttccggc 1834801 atgccaggtc cgccttttgg cccttcgtat ctgatgatga caacgtcgcc ttcttttact 1834861 tttcggttga taatgccgtc aagcgcctcg tcctgagaat cgaatacgac agccggccct 1834921 tcgtgtcttg taatcccatt ctgtacgccg cctgttttaa tgatagcgcc gtccggagct 1834981 agattaccga ataaaacagc aaggcctccc ttttcagtga atggttgatc cagcgggtga 1835041 atgacgtcat aatcctttac ttcatgtccg gcaatggttt ctccaagagt ttttcctgta 1835101 acagtcagcg catctaaatg aagcgctcct tctttcttcg aaagctcatt cagagccgct 1835161 gaaacgccgc ccgcttcgtg aagatcttca ataaacacat ccgatgcagg cgccagctta 1835221 gccaagtgcg gcacgcgctc agcgacttcg ttaatgcgtt ctaaagagta ttcaacgccg 1835281 gcttcgtttg caagggcaag ggtatgaaga acggtatttg tagaacctcc gagcgccata 1835341 tcgagtgcaa acgcgttatc aatcgctttt actgtaacaa tatcacgcgg tttgatatct 1835401 ttgcgaatcg tttccattaa ttgcgcagcc gattttctca caaactcttt gcgttccgga 1835461 gatgttgcca gaatggttcc attacccggc aaagcaagac caagtgcttc tgacagacag 1835521 ttcattgagt tcgccgtaaa catgcctgag caagacccgc acgttgggca tccgaactgc 1835581 tctagttctt gaagctcgtt ttcgttgatt ttccctgctt ggtaggcgcc taccccttcg 1835641 aatactgagg aaagggagat ttttcgcccg tcacttgttc ttcctgccgc catcggtccg 1835701 ccgctgacaa aaatcgtcgg aatgttgatg cgcattgccg ccataagcat tcccggtgtg 1835761 attttgtcgc agttcggaat acagaccatt ccgtcaaacc agtgtgcgga tacaaccgtt 1835821 tccacagagt ctgcgataat ttcacggctt ggcagcgaat atctcatacc gatatgcccc 1835881 attgcgatgc catcatctac cccaatggta ttaaattcaa acggaacgcc ccctgcttct 1835941 ctgattgctt cttttacgat tttcccaaac tcctgcaagt gaacatgacc gggaacgata 1836001 tcaatgtatg aattacacac cgcaataaac ggcttgccga aatcctcttc ttttacccct 1836061 gctgcacgaa gcaaactgcg gtgcggagct ctatcgattc cttgtgtgat catattactg 1836121 cgtaattctg ccatggtgat cctcctaaat tctttcaatt gtttgattgg attttatttt 1836181 gacaattttc agtttattta tgggctgttt ttgcaaataa gataaataca ggccgccctc 1836241 accttgtttt gttctttcgt gtttttatat ttatatagct ttctttcgat ttgaaccctc 1836301 caactattaa tattgttact tactataaat agttttcgga tatttttcaa caatattcga 1836361 aataattttt ataaaaagtg aattcacata aaaaaggtgc atgatctgca ccttttttat 1836421 ctttattcgc ctttttttct gctttccgtc atttgtttcc aaacagaacc ttttgcttct 1836481 tctccatgct caatacgttc aagcgccatt ttgacttgaa ggctgacctc aaattcgggg 1836541 tcatcttcgg cagcgcgcaa agcttcaatt gcactttcat cgccgacttc gtacaggaac 1836601 atggcggcac gccagcgaac aagcttgctg gagtcgctta atgacttgat catagcagga 1836661 atggcttgag gatcgccgat atcagacagg cagtctccgg ccgttcttct gactgataca 1836721 gctttgtcct caagtgcttt atacaataga ggaagaacat caggtgtttc aatcattcct 1836781 aagtacacaa cagcctgtct tctgatggac acctttggat catccaatgc cttctgtaaa 1836841 accgggatat cctcttcttt cggatccatc tgttccaagt gtgcataacg ctttttccag 1836901 tcctcatcat ccagcatatc aagcgttact ttatacgctt tgcgctgtac agcttgtttt 1836961 gcttcgccct ttccttgagc ggctgcttca gtcagtcgtt tcagccgttc atcactgtat 1837021 gccgcttgaa gctcttctgt cacatcatgg ccgatttcat caaagtcacc gaatctgaca 1837081 ccttgttctt tccaagcccg ctcaaacaca acattggaag cttcagatct aagttttaag 1837141 atcgcctgct gaaagcgttc aggtaagccg aagcgttctt cccgctctcc atcggttaat 1837201 ttaacttgca taggaatgcc gctgaacatc tgcacaaaaa cttttacctc tccaaaagat 1837261 tcttgatcag aacgattttc ttctgcgctt tcagcacttt ccatcccaaa tgcagtgcgg 1837321 acttgcggta aaatgtcttt ccagtcgtat cttgcattcc gttcaacagc aagaaaatct 1837381 gcgacgtgat ataccccttt aactccatct attttaagga tttccgctat aacaagcggt 1837441 gcgccttctg cttgctcagg tttatagtta ttgcttttgc ccgccggaag ctcttccgtt 1837501 aagatgactt tcattgtatt cgggcttggt gtaggttcaa ttgattttat cttcatgatc 1837561 gtcctcctat agcatatctg tgacttattc tatcatagtc gctccaagcc ttctattacg 1837621 acgtttcggc atcaatcccg ggtatgtctt tttctaattg gcggacaaat tgaagcataa 1837681 aattgtgtct ttcttctgcc agttcccgtg cagtgtctgt attcatcata tctttcagcc 1837741 gcagcagctt atgaaaaaaa tgagcgtagg cgctttgctc atctccataa aggccatgcc 1837801 cttttgcgcc cgcaaacatg aaagctctcg caatgccgac agcaccaatc gcatcaagtc 1837861 tgtcagcatc ctgtacagct tttccttcaa ttgagagcgg ctccttcgcc aatttccccc 1837921 tgtcccgaaa ggacatcctt gttataatat gaatcaccct gtcagcattc tcttttccta 1837981 ctccgaaaaa aacgagctga tcatatactt cgctcacaga aagcctgacc gtgtcaggca 1838041 gcttcacatc aattaaatca tgaaccaaag ccgccgtttc aacaatgaac aaatccgctt 1838101 tttccttttc tccaatatac gctgcaagat ctgctactct tgatacatga tgccagtcat 1838161 gtccagagct ttcgtcagtc aggatagatt gaacccatgt cctgatttgc tctgcctgct 1838221 tcaattcctt cacaaaaaca ccctcttttt attgctctaa tagcttcacg atatcgtctt 1838281 ccaactcttt cggatttgta tttggtgaat aacggccaac gatttctcca tttctatcca 1838341 ctataaattt cgtgaaattc cacttgatcg ccttagttcc cagcatccct ttcgcatgtt 1838401 ctgtcaaata cacaaacagc gggtgggcgt ttttcccgtt tacatccact tttgaaaaca 1838461 taggaaatgt aacaccgtaa tttgtttcac aaaattcctg tatgtcagcc tcttcaccag 1838521 gctcttggtt catgaattga ttgcagggga accctaagat ctccagcccc tcctgctgat 1838581 atgtatcata taattcctgc agctgcttca attgggaagt aaaaccgcac ttacttgctg 1838641 tattcacgat catcagtacc tttcccgcga aaggctgaag tgtcatgtct ttccctgtga 1838701 ttgtacgtac cttcatatga taaatagaca tgtaagtccc tcctatgtcc ttggtgctga 1838761 ttattttacc ttttttaaat cgcaattcaa aatgtaaaca tcaattaaga actcataaga 1838821 aacctaacga tatgagcgtc agttcattat caattcatat ggctcgtttt ttatcttatc 1838881 attctataaa acattacaat tccctcttac atctttgaaa atcattttac tgtgaaacca 1838941 aaaggcgtgt cagtgcgttt tatttaaaga gttttctgtt gtttccccct caacacgtat 1839001 agatagattg aaaattggcg tgaaaattcc tataatgaag aaaattaaac ggggaaataa 1839061 tggaggtggc acgttgccta ttaatatacc aacacacctg ccggcaaaac aggtgcttga 1839121 aagtgaacat atatttgtaa tggatgaaag cagagcattt catcaggata tccggccgca 1839181 aaaaattatt atattaaatt tgatgccgaa aaaaatccaa acagagactc agcttctcag 1839241 attgcttgga aattcgcctt tacaggttca tttcacattt ttaatcccaa gcacacacac 1839301 gccgaaaaat actgcgagag aacaccttga cgaattttac acgacttttt ccaatatccg 1839361 tcacaagagg tttgacggca tgattatcac cggtgcgccg atcgagcatt tggcgtttga 1839421 agaggtttca tattgggaag agctcaagga aatcatggag tggagcaaaa caaatgtcac 1839481 ttcaaccttg catatttgct ggggtgctca agcaggtttg tattaccatt acggtgtgga 1839541 aaaaattcaa atgccgaaaa aaatcttcgg tgtgttcgaa cataccgttc tttcaaaaca 1839601 cgaaagattg gtaagaggtt ttgacgagct atactacgtg ccgcattccc ggcatacaga 1839661 tataaatatg gaacagcttc aagcagtgcc cgagttaaac attcttaccg catcaaagga 1839721 agccggggtt tgcttaattg tgtctaaaga cgaaaaacaa gtctttttga cagggcaccc 1839781 tgaatatgat acaaatacgc ttcttcaaga gtatgaaaga gatttggaac gaaacctttc 1839841 tactgtcgag gcccctaaac attattttgc aaaaggcagc aacgagccag tgaatcgctg 1839901 gaaagcgcat gccacattat tgtttatgaa ttggctgaat tattacgttt accaagaaac 1839961 tccttatgaa tgggactaat ttttcttttt ttagtgatac gctgagcaaa aaatatgata 1840021 aaatacatct gattcagtct gcgtataaca aaaatttaaa atactggaat ccaaatcatt 1840081 taaaattagc ttaacttttt cactgcatta ataattcgat tatgtatttg tgttatgttt 1840141 atgtatagac aataactcct tacgatgcat gaagcttgct tgttgttgat tacattgagg 1840201 tgaatttact tgaataccaa taaaagagta ttaattttga ctgcaaatta cggaaatgga 1840261 catgtgcagg tagccaaaac actttatgaa caatgtgtac ggctcggctt tcagcatgta 1840321 acagtttcta atttgtacca agagtcaaat ccgattgttt cagaggtaac tcaatacctt 1840381 tatttaaaaa gcttctcaat cgggaaacag ttttatcgtt tgttttatta cggagttgac 1840441 aaaatctata ataaacgtaa attcaatatt tactttaaaa tgggtaataa aagattgggc 1840501 gaacttgtcg atgaacatca gcccgatatt attattaata catttccgat gatcgtcgtg 1840561 ccggaataca gacgccgaac tggaagagtc attcctacct tcaacgttat gactgatttt 1840621 tgtcttcata aaatttgggt tcacgaaaac gtggataaat attatgtggc gacagattac 1840681 gtgaaggaaa aactgctgga gatcggcact catccaagca atgtaaaaat cacaggaatt 1840741 ccaatcaggc cgcaatttga agaatccatg cctgttggcc cgatatataa aaagtacaat 1840801 ctttcaccaa acaaaaaagt gcttctgatc atggcaggtg ctcacggtgt attaaagaac 1840861 gtaaaagagc tgtgcgaaaa ccttgtcaag gatgaccaag tgcaagtagt tgtcgtgtgc 1840921 gggaaaaata cggctttaaa agaatctttg agtgcgcttg aagcggaaaa tggtgacaaa 1840981 ttaaaagttc tgggctatgt ggagcgcatt gatgagctat ttcggatcac agattgcatg 1841041 attaccaagc ccggcggcat tactttgaca gaagccacag ccattggagt gcctgtcatt 1841101 ctgtacaaac ccgtgcctgg ccaggaaaaa gaaaatgcaa acttctttga agaccgcgga 1841161 gctgccatcg ttgtgaaccg tcatgaagag attctcgagt cagtcacttc ccttcttgca 1841221 gatgaagata ccttgcatcg catgaagaaa aacattaagg accttcattt agcaaactcc 1841281 tctgaagtga ttttagagga tatcctgaag gaatcagaaa tgatgaccgc caaacaaaaa 1841341 gccaaagtgc tatcgtaatg gcgtacttga gagcatacga aaatcgtgtg ctctttttat 1841401 ttatattcag ccatcaataa aagcggttac atttttttat ggaacttgcc cttcttttga 1841461 aaaataagcc gtttcgcaac ttgacgggtg ctcccagatg gtgtatagtt gaaccatcat 1841521 ttaacaatga atcaaagtta gatgatgaca aaattttttt tagcacatgg gtgctacagt 1841581 actaggagga attaagcaat atgcaaaacg gtaaagtaaa atggttcaac aacgaaaaag 1841641 gattcggctt cattgaagtt gaaggcggag acgatgtatt tgttcacttc acagctatcg 1841701 aaggagatgg atacaaatca ttagaagaag gacaagaagt ttcttttgaa attgtcgaag 1841761 gtaatcgtgg acctcaagct tctaatgttg taaaactcta aactcaatac atgatgatga 1841821 gatgacaaat agaggagagg cattcgcctc tcctatttga ttttcatctg gatttcaatc 1841881 gccaaaatgt tttgtttaca cctctgttca atctcttcaa catacttttc cattgatggt 1841941 tttccttttt tcgcgatatc ggccagttct tctaaatcac tgtatatttc tataaatgtt 1842001 ttgtgaagga tcaacttcaa gtctttatca tccatagctg cgttcccctt ctctatcaag 1842061 atacctcaaa tagtaaaacg gtcctattta ttctggttca atagttatat cggcttattt 1842121 ttattttctt ttctattttg gtacataaat ttcaaaaaaa ctctgcaaaa taatggcgga 1842181 ggtgtttttt gtgacttcag aatttcataa tgaggatcag accggcttta cggataagcg 1842241 gcagctggaa ctagcggtgg aaacagcgca gaaaacaaca ggagccgcga cgagaggcca 1842301 aagcaaaaca ttagtcgact ctgcatacca agccattgag gatgctagag aactgtcaca 1842361 atctgaagag ctggcagctc tcgatgatcc tgaatttgta aagcagcaac agcagctgct 1842421 agatgacagc gagcatcagc tggatgaatt caaagaataa aaaccgcagc ttctgcggtt 1842481 tttattttta gtgattggtt aagacatctc cgtattgttt caacttttca ccaaccgtac 1842541 atttattgat acaaaatgaa tgcgcataag ttttgccaaa ttctttgcga aactgcttct 1842601 taataaaaca gtccttgcaa tattcatcgt gcagttctgt cagttcttta aagatcattt 1842661 tcttatccaa tatcgtcatc tccgttacgg tctaatttcg tgtggctttc tacgaattga 1842721 tgggatagaa tttttttagc gaggccgtca gcttcctgat tgtcttttcg ttgtattgtt 1842781 tcgtaggttg gagtaagctt cagcgattca aggagtgctt ctattttgtc cagccattca 1842841 ttatgagatg gatcataaca aggccagctg ccgtcaagct gattcagcac aacaagcgag 1842901 tcccctttga ttgtaattga atttctgctt gccccaagct ctcttacttc tcttattgct 1842961 tcataaagcg ctgcgtattc agcttcatta ttggttttca gccggaagct tttatttttt 1843021 ctcaagcgat gccgggttcc tcccaatgaa taatagatga cgatcccgag accggccagt 1843081 tcgctctctt tatcgaaact gccgtcaaaa taaacagtaa tgtcatcagg ctcttgagca 1843141 agctcctctg tcagcttttc caattccttc agcgtccagc tgccgccttt ctcgtcttcg 1843201 aactctagct ccttcatgta tggaaaacgg ccaagttctc tggcgaacgt acgtgcctgc 1843261 tgtgctgtca gccagtcttc gctaaaaaat gagacggatc ccgttccttt tgcttctatt 1843321 ttcaaatgcg gtctgagctt cattacaatc accttaccat tcattagttg ccgggcttat 1843381 gctataatca aaccaatctt accccggaaa ggaagctttt tcatcttgtt taataattcg 1843441 ttttggatct tttttgcgat cattcatttt atcattgttc ttttatttta taaaggattt 1843501 ggcaaaatgg gactgtttgt ttggatcggt tttgcgacag tctgcgccaa cctccaagtc 1843561 gtcaaaacag tcgaactgtt tggcttaaca gcgacactcg ggaatgtgat gtatggcaca 1843621 atcttttttg cgacagatgt gctgaatgaa aaatacggac cagctgaagc cagaaaagcg 1843681 gtatggctcg gattctcaac gctcctgacg ctgacatttg tcatgcaggg cgtgctgctt 1843741 ttcgaaccgg cttccagcga catatcacaa acagcgctgg aaacgatctt cggattcctt 1843801 ccgcgagttg cgttaggaag tctgcttgcc tttatcttca gccaaacgct ggatgtttat 1843861 gtatattcgg caattagaag gatatttcct tctgatcggc ttttatggct cagaaacggc 1843921 ggcagtacag cagtcagcca gttgtttgat acattcatat tcactgcagt cgcctttctc 1843981 ggcatttatc cggcagacgt gtggcttcat atttttattt ctacatattt gattaagttt 1844041 gcggtatctt taatttcatt gccttatgcc tatgcagcca aaaaaatgat acctaatgat 1844101 gaaaggagtt cataatgcct acagaaatat atgtagacgg cgcaagcgcc ggtaatccag 1844161 ggccttccgg tatcggcatt tttatcaaac atgagggaaa agcagaatct ttctctattc 1844221 caatcggagt gcatacaaac caggaagcgg aatttcttgc attaattgaa gggatgaagc 1844281 tatgtgcaac gcgcgggtat caatcagttt cctttcgaac cgattcagat attgtggaac 1844341 gcgccactga gcttgaaatg gttaaaaata taacgtttca accgtttgta gaagagatca 1844401 tccgattaaa agcggcattc cctctttttt tcatcaaatg gataccgggc aagcaaaacc 1844461 aaaaagccga tcttctggca aaagaagcga ttcggctgaa tgaaaagaat taaatcttga 1844521 tcattggttc atcctaatgg cgaggtgaac taacatgaaa aagaaagata aaggccggct 1844581 gaccggcggt gttactccgc aaggcgacct ggaaggcaat acacataatg accctaaaac 1844641 agagcttgag gagagagcaa aaaaaagcaa tacaaaacgc tagagaggat ctaaacgatc 1844701 tctctagcgt tcagcttttc aagcatacgc tcaattcctt taatttggtg gcggcgaagc 1844761 atgtcagccg cctgctccat ttgcaaagta aataaagcgt ctttcagtgt gcaggccagc 1844821 ggcactgagc aatggatttc cgcaagcttc ctcgacatct ccaaatcgct taaaccttgc 1844881 tgaatttttc cctgctgtcc ttttggaaga agagaaagat tttccaataa acggtcaatc 1844941 gtttcgtatt cacgaatcag tttgtaggct gttttttctc caatgccttt gactccggga 1845001 tagttatcac tggaatcacc cataagcgct ttaatatcaa tcaaagcctt cggcattacg 1845061 cctgtttctt cataaaaagt ctcttttgta tagactttat aatttccgat tcctttttga 1845121 agcaaagcaa cgcttacttt atccgttaac agctgaagta aatctctgtc ccctgttacc 1845181 accgtaatgt ccgcttcatt cgcaaataaa tcggcaagag taccgataca gtcatccgct 1845241 tcatagccgg caaagccaat attcatgatt ccaagctctg cggctgcttc ctttgccaaa 1845301 tcaaactgcg gaatcagctc cacaggcggc gcgctgcggt tggccttata atcttggaac 1845361 aagtcatttc ggtacgtttt gctccccatg tcccagcagc agacgacgtg tgtcggctgg 1845421 aatgtttcca cagctgtaat caaatgcttt aaaaagccgt tgacgccgtt cgtcggcacc 1845481 ccgctgtcat ttatcataaa gttgcgatgt acggccgtgg caaaaaaggc ccggaataaa 1845541 agagccatgc cgtcaaccag caatagttta ttattattca tcaaataact cccttttctt 1845601 tcattccttc tattttatca taaagcagcc caaaaataaa aaacagtatc tctttaatta 1845661 gagatactgt ttgaatattt atcaatcgtt gtgtcttttg ttgctggcga tcagcttttc 1845721 agcttcgcgt cctgcgtaag agtcaaaatg ggtttgaaat ccgtttttct ttttggcgtt 1845781 gttattcgcc tgtgcatttc tgtttccgag ctttgttctg cccaacatga atcccccctt 1845841 acgtcggatg catatagtat atgcttccgg caggaggttc actcgcgaca ggatcatcca 1845901 gcttacatgc ggcttacgta ttctctgacc atttcttttg atacaagccg tcttgtcggg 1845961 acgatgcctt ttttagcgag ctgattcatt tgctcggtaa tttcattaat tgcatctgta 1846021 gtataaggct catcgtttct gcatttagca acagcttctt caatcgccaa ttcacgcata 1846081 ttttcaagac gcataaatgc tttgatatgc tcgtgctgtt ttgatgaatg tgctgaaatt 1846141 gctttatgta cctctgacat taatcgttca tctcgctttt ttctatttag tctatcatga 1846201 cttgaaatac aagccaactg aattttacat ttttattgta ttgtctgaat ttttccagga 1846261 gatgcacgcc tgatacgcca tttcaatctc tttcgcatgt tccccttccg catatcctct 1846321 taaatatgtc tctttttgat ccgttatttg cgcgattgct ttttcaccca tatcttcctg 1846381 taagcgtctg aggtgagcag tgtaatgaga tatcaggctt tcttcttcat tttttatcca 1846441 tgcctctgtg attttcgtaa gtttcatccg tacagcttcg ataaaggtcg cttttccttt 1846501 ctgctcaaaa aactgcttcg gtgatttgat ctcttttagt tcctgctcaa aagcacgttc 1846561 ttctatttcc ggttcaactt ccttcaactg tatgccgttc gaatgctgat cacccgcata 1846621 aacggaaaaa taaccgtcct cgtttaatgt tttttgaaaa tgatccagcc attcttcatt 1846681 gatatgccgt tcgatgaaac cgctcatgcg aacatcaagc gttttgattt cctgaatata 1846741 ttcaaataga tattcatgta aggctgttgt catcgcttta ctgacgttct ttttccaatc 1846801 cccgttttgc agcccgggat gaaatgccga ttttaataaa tcatttgcaa aatatgataa 1846861 tcgctgtgca atgtgatata gctgctctct tgtatctttt tttacttttt caatgatggt 1846921 ttttgagttc cgccgtttct cgatatcggc cgctgtccgc tcaaatgaca gcataaggca 1846981 ctgtttctgc gcttccttct cttctcggga ctgatgctgg gattggtgaa gctgaaaaac 1847041 agtttcgcat agtttgtctg cctccgaact gagctgcgct gctgacgctt tttttacatc 1847101 cacttcgata aaccggtcta agtgttttct tactttcgag aactgattat aaaatgactc 1847161 cggttttccc accagttcct ccttacttga tacggtaaag agctgcggct cataaacccc 1847221 ttcttttaca agctctgcgc tgacataatc ggtcactgtt tcgagctctg ttttatcttt 1847281 tgcaaggtct gcagcattaa taataaaaaa cattttatcc atgctgagcg attctttcac 1847341 aagtccaagc tttcgcaaaa atgaacggtc tccttttgaa aaagagtgct gataataagt 1847401 catataaaaa aatgcatcag catctttgat atattggaat gccagttctg tatgccgttt 1847461 attcatgctg ctcgcgccgg gtgtatcaac gatcgtaatc cctttttcag tgagcgggca 1847521 tgtatagtag accgttacct ctttcacagc acaggccgtt gtttcctctg ctacatacgg 1847581 ctttaattca gagagcggaa tcgttaattt cttctgttcc tgtatatact gctgatactt 1847641 ctcgtatgca agcaggaaat tgctgatcaa tttcacgtgt tcttcctgca gcctgttttt 1847701 tttgactgcc ttttcccact tctctgtgaa ggaacggcct gccggctcct ttggtattcc 1847761 ggtgagctgc aaaatttcag ccgttaagtc atcctctgtc ttaaacacta cattcgctgt 1847821 tttgtttaag ttgccattga ttggctttgt gatcttgtta attgtcgctg tggttggcgt 1847881 tggtgaggat ggcagcactc tttcgccgac aagcgcattg gcaaatgatg atttccccga 1847941 gctaaagcct ccaaaaagag cgagtgtaaa tttccgttcc tcaagccttt tcaccctttc 1848001 acgaaacgct gaagtttgct ttaacaacat gctgcattcg cctaaaatgt cagacaaagt 1848061 gtaaaagcgt ttgatttggt cttgaagcgg catttcttgt tccattttga tttctgattt 1848121 cggcatcggc tgcgccgtca gctggcttcg gccttgtttc tgctctggag ccgccactct 1848181 tgttttcttc gatttaaacc attctgtgtc tatatgcatt gggcatgcgg actcttcttc 1848241 ccaaatggcc cacaggcgat cggttttctc tcgggcatta ttctctaaac gtgcctgttc 1848301 ttgaagaaag acaagttttt ctgattcttg gacgagccgg tcgttaattg tttgcacatc 1848361 tttggaaaca cgctctttca ccatagcgga gagcaccttt atgatgtctg cggcttctct 1848421 tttcgcctct ttccggatga gctctgccaa gtcttttgta tattgcaata catattcaga 1848481 ggaaaaggct gcaccatgct tgaccgcgtg ttcaatgatg cttatatcaa gcggtgtgcg 1848541 ataggcctga atcagctttt cactttcagc ggtatagaca tcaaatacct tggcgagttt 1848601 atgaagcgtg tctatcatat gccaatccgc ttcggcctct gttcgttttg ccacatcaga 1848661 gaaaaaagca ttccgccttt tatctctttc ctgtgcagtt ttcgctttag aaaagaaaaa 1848721 gccggtttta aaggaaggct cttgtgattc taaaaatgca gccgccaatt cacgcatttc 1848781 aaaaggcgtc aggttggcgt tttttaaaat acgattgatt tcttcctgca tcctcttctc 1848841 tgcctcagtc atttgttttt cggcctcatc caattgatca cgcagcgatt ggaccagtcc 1848901 agtatggata ttaagctgtt cagcgaaact cggagcgcct gtttcgtctt tcttcagcat 1848961 ttccgtatgt tcctttagca gattacggac tttttgttcg gttaaagcct gcatattgct 1849021 ttttgattgc tgttctattc tgcttaactc ttctctcagg gcccccatct gattgaacgg 1849081 gtgatccggt tctgttactg atgtaaaata gagcgcttcc cttgaaatcc cttcattgca 1849141 aagcatctcc tctacctgcg cttgatagtc tccaaatttc gtctccgtct catcatggcg 1849201 gtcaatttga ttgacgataa aatacacatt cggaatgctt tcttttattg atctgagaaa 1849261 ctttacattt tcctcagcgt gcacgtgatt atagtgaacg acgtaaaaca gcgcatccgc 1849321 ttggtgaaga atagaagcag ccgatagaaa atgcgcatca tctgttgaat ctatccctgg 1849381 agtatcaata tacgcaaccc cggaatcgat ctcagtatac ctgtcaaaaa tttcgacgct 1849441 ttcaatctgt tccccgtctt tacaatattg ctgcaccttg tctttctggt aagtcccttc 1849501 cagctcagca cacgctccgt ctgttgtatg aagccgaact cgcttttccc cgtttctgat 1849561 cacaacaagg ttagcgcttg tcggaatcgg gcttgtcggc aaaatattct ccattaacag 1849621 gcagttcagc agtgacgatt tccccgctga ataatgcccg gtaaacgcga tataaacctc 1849681 ttcatcagcc gcttttttca tgaccgcagc cagtttagca gccctttgtt catcttgatt 1849741 ctcaataaat tgcttataaa gttccccggt tttatgcaaa agctcttttc tgttttgatc 1849801 tgtcataagt ctgaacccct ttgtgccgtt tcaattgtga acctttttcg aaagatctga 1849861 attcattccc ttttcatttt acacaagaat aaaccaaatt tctttaggag aatagaaaaa 1849921 agccgccatt acggcagctt ctataaaaga aaatctgcaa cttttacaag ttccagattc 1849981 atcaaacaga tttattagag attcctttta atacaaaacc aattaataca ctatatgtac 1850041 aaaccgctcc aagcaaaaac agcattgtca tttgcttcac catcctgatt gagaatcttt 1850101 ttcaaaccca ttttaacatg gttgagaatg attttcaatc gctattttac gctgtattcc 1850161 tgtaatgctt tgtcttctgc gcgaattctg acgcttaaca acacggcatt gaaaatggaa 1850221 aacagacaca tggtgacgta tgcttgataa agcagcggaa tcagcaaaat ttcgaggata 1850281 acaacggcat agtttggatg tttcatccat ttatatggac ctttttttac aagctctaca 1850341 cctggaacaa caaggatttt cgtattccaa tatgctccta aggaacaaag cgcccaatac 1850401 cgtacgatct gtacgcttaa aatcactgca gcgataccga gccaccagct ggacggctgt 1850461 ttattcatca gcagcacctc ggcaattaag gacaggaaaa aaaggatatg catcgtaatg 1850521 atatacggat agtggctctc gccaaattca attgctcctt gcttctttac cttttgttcg 1850581 ttttgcctgg ccactgccat ttctgctgct ctttgaacaa tgagaatggc gatcaacaac 1850641 caaaacatga gtcaggcccc cttttcccag ctgaataata gcaactctga tgagaaaccc 1850701 ggccctaatg cgccaatcag tcctcgttca gcttcctttt tatgtccgtt ctgcagatgg 1850761 tctttgatca catacaagat tgtggctgaa gacatatttc cgtgcttttg caaaatgctt 1850821 tgcgcagatg aaagcttttc tgacgacagc ccgagacttt tgatgtatgc atcgatcact 1850881 ttttttccgc ctggatgcgc caaaaaaaca ctgatatcat ggaatgacag cttatgtttg 1850941 tccaaaaaaa tctgtacatt tgttttgagc catttttcca ccaaggtcgg aatgtctcgt 1851001 gagaaaatga ctttgaatcc ttgatcggta aagtcccagc ccatgacatc ttctgattgt 1851061 ttcatcaaaa cagattgggc gtccattatc ttcggcgcaa gcttcagctt tgacaccctg 1851121 cggtccgcct tctctccgca taataaagct gcggcaatgc cgtcaccaaa aagcgaggtg 1851181 ccgatcagat tgctttttgt tttatcttcc ggctggaatg tcaggctgca cagctcggca 1851241 gaaatgacaa gcacaaaagc ctcaggatac gctttgcagt attcggctgc acgcgcaagt 1851301 ccgctggctc ctcctgcaca gccaagcccc caaatcggaa tccgcttcgt atatggagaa 1851361 aacggaagtt cattcataag ccgcgcctcg atactcggtg tggaaagacc tgtactggag 1851421 acgaaaaaaa cagcttccac tttctcataa ggaatggctt cttgaaaaaa ttccggatga 1851481 gagaggcact cacgaacagc cgctctgctg tgtttaagtg tttcttctat gtatatttga 1851541 tttttttctt caaagctgtg cccctcttta taccattcaa tcggcttaac aaactgtctc 1851601 gaatggattt gcccgttttt aaaggaggat aacagcctgt caatatcctt aaaagaatgc 1851661 tgaaacatat agcgggcgaa ctcggccgct ttctcttggt ttacattata cgcaggaaga 1851721 cttgttccaa tggataaaat aaacgccatg cgatcacctc tttgcataca ttgtgccgca 1851781 acaatctttt ttatatgcaa aaaaaactcc gccgcggcgg agttagactg ctgttttttg 1851841 ttcagcgagg tcagcttctt gttctatttt tttagcttta gaaaaaacgt tatatacaat 1851901 atttaagacg actgcagtaa agctgcccgc cacaatgcca ttcgttgtaa gcagcgttaa 1851961 ggcactcgga agctgtttga aaatatccgg cacaacggtc acaccgagcc ccaatcccac 1852021 tgagcaagca acaatcagca gattttcctg tttcgcaaaa tcaatgcggc tgagcatttt 1852081 aattccgtaa gcaatcacca ttccaaacat cgccaccatt gcaccgccca aaacagcgga 1852141 tggaataata gtcgtgaaag cagcgatctt tggaaacagc ccaaatgcca ttaggatcac 1852201 acctgtgacc acaatgacgg catttttttt gatccctgtg agctgaacaa gcccgacatt 1852261 ttgagagaat gccgtgtaag gaaaagcgtt aaaaataccg cccagaagca cagccagtcc 1852321 ttcagctcga tagcctttag acaaatctat ctctgtcaaa cggcggtttg tcaggtcacc 1852381 taaagcaaag taaacaccag ttgactccac aaggctgaca attgcaacga tggacatcgt 1852441 aatgataggc gctgcgtgaa aagacggcgc tccgaagtaa aatggctgaa tcatttgaac 1852501 aactgccgcg tccgaaacat tatcaaattg aacttttccc ataaaatatg cgatgaaggt 1852561 gccaatcaaa ataccgatca aaatcgagac ggacttgata aagccttttg taaaacggta 1852621 tagaagcaca atgatactca acacggtaaa agcaagtgca agattggaga gatctccgaa 1852681 atctgcactt ccttctccgc cggccatgtt attcatggca accggcatca gtgtaatacc 1852741 gataatcgta acaacagagc ctgtcacgac cggcggaaaa aacgatacga gctttccaaa 1852801 gaaaaatgaa ataagaatga caagaatgcc tgaagcgata atgctgccgt aaactgttga 1852861 aaccccatat tcagatccaa tcgctatcat cggcgataca gctgtaaagg tacagccaag 1852921 cactaccgga agcccgatcc caaaaaatcg gttgctccac acttgcagaa gtgtagccac 1852981 accgcacata aaaatatcaa tcgatactaa gtaagtcagc tgctcgacag tcagtcccat 1853041 tgcttttccg acaatcagag gaacgacaat ggcgccggca tacatggcaa gaacatgctg 1853101 aatccctaaa gacagcgttt tgccgaatcc atttctcatg aatgaacctc ctgtacgaag 1853161 gacacttttc cttcttctaa agactgaatt cttgccaaag attccactcg gtagcccagt 1853221 tttacaagtt catctcttcc cggctgaaat gacttttcaa taacaatgcc gattcccgca 1853281 atagaagctc ccgcttgctt cacaatcgac acaagcccgt gcgctgcctg tccatttgcc 1853341 aaaaaatcat cgataatcag cacatgatcc tgatccgaca ggtgggtccc agacactgcg 1853401 atttggcttt ctgtttgctt cgtaaaggaa taaacagacg ctgtcagcaa gttgtcggtg 1853461 agtgttaacg atttatgctt tctcgcgaag acaactggca cacccagctt caagcccgtc 1853521 attacagcgg gagcgatacc tgatgattcg attgtcacaa ttttggtaat accgtctttt 1853581 gcaaacctag acgcaaattc atcaccaatt ctctgcataa gcagcggatc aatttggtga 1853641 ttcaaaaaag aatccacttt caatacctga tcagataata cgacgccttc ttcctctatt 1853701 ttccgtttca gtgcttccat cctgtctacc tccgttatga gaataaaaaa agcattgccc 1853761 gctcaaataa agagcaagca atgctgatat cacaaaaaac cgtacacgtg cggttccatt 1853821 gctcacccat agtcggacat ttacggtgcc cggtagaaac ttgcgtgcca tatccacgcg 1853881 attatatgag tgttcctatt atattgtaat aaattatatc aagattctaa tctcttgcat 1853941 aggctgaaaa taaaaattcc cgaactttaa ttttgttttt ttagatatca ttcgtatttc 1854001 aaggggattc gatataaaag agtctgacga ccgcgccgcc aggcttttga ttataacaga 1854061 tagagatttg aatatttgtt tgataaataa tcaattaaat agcgaacatt cagctcttct 1854121 cctgttgcat ctttaataat gtctaacggc tttttccgtt ttccgtgaat gtgcaccttt 1854181 tccgtcagcc attgctttat cggatggaac tctcctcttt ccaagagagc gtcaaattca 1854241 gggagatcct caagcatttt ttgtttcagc tgagccgcat acatgtagcc gagcgcatag 1854301 gatgggaagt agccgaaatc tccacctgcc caatggacgt cctgtaaaat cccctctgcg 1854361 tcggtctgcg gtgtaatccc taaataatcc tggtattttt gattccaaag cgacggcaga 1854421 tcttccacag acacttcatt gctgaaaatc gctttttcaa tttcataacg gatgatgata 1854481 tgaagaggat acgtcaattc atccgcttcg accctgataa atgaaggttt tgattcattg 1854541 attgcccgga caaaatcatc cagggagatg tccttgaact gtacaggtga tgcctcttga 1854601 atcttcttat agtacggagt ccaaaaatgc ttgttgcggc cgataaaatt ctcgtaaaat 1854661 aatgattgcg attcatgaat tcccatcgat gcgccgtctg acaagttcgt gccactgagt 1854721 gcttcatcaa tattttgctc gtaaatcgcg tgcccgcact catgaatggt cccaaagatc 1854781 gccgtccgga aatctttttc atcatatctc gtcgtgaccc gaacgtctcc ccgattcagc 1854841 gtagttgcaa acggatgaac ggtttcatca agtcttccgc catcaaaatc gtagccaagc 1854901 tcctgtaaaa aatacagact gagctctttt tgcttttctt tcgggaacgc ttttgtaata 1854961 aagcttgtat ctggtttatt tccggaagct gtcacctgtt taacaagagg gataatcgct 1855021 tccttcagct cagcaaacaa ctgatcaagc acctttaccg tgacgccggg ctcaaacaaa 1855081 tcaagcaatg catcataagg atgctcttga tatccccaat acgtaataaa acgtttattg 1855141 aattcaatca gctgttctaa ataaggagaa aacaagctga aatcagattt tcctttcgct 1855201 tcctcccacg ctgtttctgc ctttgaacac agaatcacgt attctttgta ttcagcctca 1855261 gggattttct tattctcttc atactctttt ttcgccagtt ccactgcttt tttcgtatct 1855321 tccgacaagt catcaaatcg ttcatacagg acatcgataa gctccttcat tcgatctgat 1855381 gtttggatat tgaatatatc tgttgaaagc tggccgatac tttcggcacg atcctctgag 1855441 ccatttttcg gcgcgcctgt tctggagtcc cagtgcatta acgcaactgc ttcgctgtaa 1855501 tgtgagattc tttttaaaag atcaaaaaat tctttttcat atgtatgtat ctccatatcc 1855561 attccctccc tattctagcc gttccattac aggctaatgg aagggggtat gaaagtcaaa 1855621 ttgtttgtat aaaaggctgc cggtatgttt tgtggcagcc tttttattca gttgatcgtc 1855681 atttgatttt ttggcggagg tgttctccgc tttttctgct tgattttttt atctacccac 1855741 actgttgcca gcggggttaa gagcgaggtg acaataacgc ttgtcgcgat aattgcagtt 1855801 gccgactcag caactggcgc aaatgaggca ttcgcttccg ctaatgcata tggcacggct 1855861 acagccgccc ctgccgtaga agaagcggcc actcccgcga caccatctcc ccgcgcaata 1855921 aaacgatcaa gcaaaaacaa agaactgccc gataaaatga cgacagaaac tccgataaaa 1855981 atgccgagca gccctgattg gatcagcatt ccaaaattca aggtattgcc gagcgaaaag 1856041 gcgaaaaatg gaatgatcgc cggcacaacc ttgctgaata agtctctgag atcatgatcc 1856101 agatttccaa gtatacatcc aagtaaaaac gggatgactg tcgctgccag cgtttcccat 1856161 gggaatgcgg caagtcccgt cacaccaaac gtcaccatgg tcataaaagg accagattct 1856221 gtactgataa aggcgaaagc gcccgcatcc tcttttcttc ccatgtgatt catgagcgcc 1856281 aaatacagtc cgccgttcgt ttcattcatt accgcgacaa ttgctaaaac agaaaggcct 1856341 gcaaaaaagc cggattgtat gccatcgtca ggtataaatt gcgctgcgat cacgccgagc 1856401 agcgccgcaa atccgatctt ccccaataat aacgtgattc cttttcttgc gatatagcct 1856461 gaagaacgaa aatcaatcgt tgctcctacg caaaagataa aaacacccag tatcggcagc 1856521 gttccggtaa tcaaagcacc cgtaaaccct ccaaagaact ccgctgttcc aggcgcaaac 1856581 gtgttgagcg ccgctccaag aaatagcgga ataatcatca ttccgccagg tacccgttca 1856641 attgtcgcct tgattttcat attgtggatt ctcccatcct ccggttatga aaaaacaatt 1856701 ccacttacac ttggaaaaca gcctgcaaat cctcttttga acagctgccc aactggctgc 1856761 cgactccgac ggcgccagct ccggctctaa gccaatcagg cacttcagac ggatgtatcc 1856821 cgcctgtcgg aataaaggtc acctgcggga aaggacccgc taaatttttc ataaacggaa 1856881 tgccaaacac accgcttggg aacagcttta atgtcgtaaa accgaatgtc agcgcttcca 1856941 taatttcgct cggagtcaag acgccgggga tataatgtgt ctttacaaaa gatagatgtt 1857001 cagcaagatc agctgaaaaa cccggactga caataaactg cgcgccagcc ttagcagctt 1857061 ccccagcttg ctgcgcgctg atgaccgtac ccgcgccaat taaaatatct tccctattac 1857121 ggaaggattc gataatatct gatgccccgg gggtcgtata cgtcacttca actgcacgaa 1857181 tccctttatc taataaactc tcaatctgct gacaggcctc ctgcttatcc tttgaacgaa 1857241 tgactgcaat cagctttgct tctttcagac ggttttcaac gactttggac tccatattaa 1857301 taatcccctt tcttttggtg aaccgttctt tgagcagata aaaaagaagc taatttctcc 1857361 ctggtcggca aaccgtccat atcccccggt gcctgcactt gcaaagcgcc aatcgcattt 1857421 cccctttgca ccgcatcctt gtacgacaaa ccgtctagga taccgctgat tacaccgact 1857481 gcaaatccgt ctccggcgcc gaccgtatca accacccggt cgacccggca gccttctaga 1857541 aatccttcac ttgtccccgt tttaaagtaa gcgccttctt ttccaagttt aatagcaaca 1857601 aagctggcac cttttttcaa ataatagtcg gcaatgcctt caggtgtttt ttctccggtc 1857661 aatagctctc cctctgcgat acccgggaaa aaccagtctg caagcccagc cagatcattg 1857721 attgtgtgta ccattgttgc ttgatcaggc caaagcgaag gtcttacatt agggtcgaat 1857781 gaaatggtct tccctgcgtt tctcatgtcg ttcatgacat gatacgtgaa gtctttcatc 1857841 tcggctgata aagcaggcgg aatacctgtc acatgcaaat ggcctgcgca ttgaaaataa 1857901 tctctcggat attcagctgt agttaatgtg cttgcagctg agtttttcct atagtaggta 1857961 acttgcgggt cgccttcttt cacttttgac ttcagcagca gcccggtggg attttcgtcc 1858021 tgcgagcgga tcacgcggga cacatccact ccctcttttt taagctcttg taaaataaac 1858081 gttccgagct gatcattgcc gaccttgctc atccatccca ttcgaaatcc gagtctggca 1858141 aggccgcagg cgacattgct ttctgctccg gcaagccctt tagaaaaagt ggatacttca 1858201 tgaaggcctc catactcatt tgcataaaac atggccattg attccccgaa tgtcaccgca 1858261 tcaagcttca tctcttccca acctcctctt agttgagggc acctaggatt aaagtgactt 1858321 tctcatgatg acttttgcct ctaattcaat ggtttgaggc gctcctttgt caccttcaat 1858381 cctttttaat acacgttcca tcgccgtcct gcccatatca tgtgacggct gggcgatcgt 1858441 tgtaatgcct ggaccgatca gtttgtacca ctccgtatca tcgaatcctg caatccctat 1858501 atcttgaggg atgcgcaggc caagctcttc catacagctg atgattttca gcataatcaa 1858561 gccattcaaa gccagaatcg cttttttttg ctccggcatt tccttgtgaa aagaacgaag 1858621 ctccgcctta agctgctcct tgtcctttac gtcaatttca tgcaatctga caagcccgtt 1858681 cacattttga accgaagcca tttcctgata cacagctgct ctttctgcac gagggctgat 1858741 agaggaaatc ggttcggtaa acagcgcgac atcagtatac cctttgctgt acaccttctg 1858801 aagaatctct tttgtgatcc atctgttgtc agtcgttacg gtatccagtt tcagatccgg 1858861 cagtttccgg tcaattaaga ttgttggaat ttgctgttca gcaaaagcgc ggagtacatc 1858921 cttgttttcc cctgttgcgt ttaaaatcaa gccctcaacc gaatgggctt ctagctttaa 1858981 gagcatttcc cgctcttttt caggactgtt atctgtgttg cacaccataa tgctgtatcc 1859041 atattgatca caaacctctt cgactcccct gaaagcagcg accgaaaaag gatttgtaat 1859101 gtcagccaca acaaatccga ttaacttgct tttttttatt ttcaaacctt gtgccatttt 1859161 actcggccga taattcaatt ctgcgattgc ctttttaatg tttttcactt tttcaggaga 1859221 aatcgcgtca atttttccgt taatatagcg ggaaactgtc gatttcgaaa ctcctgcaca 1859281 ttcagctacg tctttgatgg ttgtatggcc tgttgttttc tttttcattc aagtgctcct 1859341 gtatctcata tatttgaaac cgatttcaaa accgttacaa caaaagaata ccataatttt 1859401 aaaatttggg aagagttttt ttaataatat gtcaattcat tattttttcg ttgactcttt 1859461 tcactattta tcctaaaatt ttctttgaaa ccgttaccaa aatattttca ttcaagtgat 1859521 gctgaaatcc taaccaaggg ggaaatataa tggaaaatcg ttattctgta catcctgaac 1859581 aagtaaaacg ctttacaaca gaggagcttc gcagtcattt cttaatggat tctttattta 1859641 cagaaaacaa acttacgatg tattactcac atgaagaccg ggttgtcatc ggcggagcgg 1859701 ctccagggca aagtgaactg aagcttgatg caggtgattt tctaaaaaca gacttctttt 1859761 tggaacggcg tgaaatcggg attattaatg tcggccagcc tggtgccgtt agagtcggcg 1859821 atgatgaata tgtgcttcaa acaaaggatt ttctctatat tggaatgggc aatcaggatg 1859881 tatcgttttc aagcctgaac ggggaaaaag cgaagtttta cttcgtctcc gcttgcgccc 1859941 acaaaagcta tccgacacaa aaagccgccc tatctgaact gacaccggac cgccttggtg 1860001 atgatgcagc gtctaatgtc agaagtctgt acaaagtcat tcatcaggat ggcattaaaa 1860061 gctgtcagct gatgatggga ataacgatgt tagatcaaaa caacaactgg aataccatgc 1860121 cagcacacgt tcatgaccgt cggatggagg cttatcttta tctggatctt gaaaaggact 1860181 caaaggtatt tcatttcatg ggccagccgg acgaaacacg ccatcttgtt gttggaaatg 1860241 agcaggctgt cctttctccc gcttggtcta ttcattctgg cgcaggaaca tcaaactata 1860301 gctttgtgtg ggcgatggct ggagaaaatt acacatttac ggacatggat ctcattccaa 1860361 tggatgggct gaaataagat gggttatcta catgacgcct tttcattaaa aggaaaaaca 1860421 gcgctggtga caggcccggg aacagggatc ggtcaaggaa tagccaaagc cctagccggg 1860481 gctggcgctg atattatcgg cacatcacat acaagcagtc tgtctgaaac acagcagctt 1860541 gtggaacagg aaggccggat atttacatct tttacattgg acatgagcaa gccggaagcg 1860601 ataaaggatt ctgcagctga gctgtttgaa aacaggcaga tcgacatcct tgtcaataat 1860661 gccggcatta ttcatcggga aaaagcggaa gattttccag aagagaactg gcagcacgta 1860721 ctgaatgtca atctaaacag cctgtttatt ctgacacagc ttgctggcag gcacatgctg 1860781 aaaagaggtc atggaaagat tattaatatt gcctctctcc tgtcttttca aggcggcatc 1860841 ctcgttccgg cttacaccgc gagcaaacac gctgttgccg gtttgacaaa atcatttgca 1860901 aatgagtggg cagcgtcagg tattcaggtc aacgcaatcg ccccaggcta tatttctact 1860961 gcgaatacaa agcctattcg ggatgacgaa aagcgaaatg aggacatttt aaagagaatt 1861021 cctgccggcc gctggggcca agcggatgat atcgggggga ctgcagtctt tttggcatca 1861081 cgtgcttcag attatgtaaa tggacatatt ttagcagttg atggcggctg gctatcccgc 1861141 tgacaaataa aaaagctgac gaacgatcgt cagctttttt ccattacatc atgtgcggtt 1861201 caacaggcaa gacctttttg acctcatcaa tgatgcgttc attttctccg ccagcgtaaa 1861261 tgtgaatcga gccgctgtct tgattcgagc gaatcaggcg cccgatgccc tgccgtacac 1861321 gtaacaacat atatggcaga tcaacttctt cgaacggatc ttttttcgct ccgttgcgct 1861381 tcgctgtaaa tacaggatcg tgtggcggga acggtaatga ccaaatggta acattcttca 1861441 atgcgtcacc gggaatgtcg agtccttccc ataagtgaac tgaacaaagt actgtttctt 1861501 cttcctcttg gaatttctct actaagctgc tgatttcctc atcaccttcg aagaaaattg 1861561 gatacggcag ctcccatgcc gccgacagct ctttaaactc gtttaattct tcaaaagaag 1861621 ggaaaagcac cagcgttctt cctttgtatc gtttgattgt ttcaatcgtt tcagccgttt 1861681 tttgttcagc gtccatatct gtttttgcgt atagattaat actcatttgc tcgtcataat 1861741 cataagggga atcaacagtt aatgacaaat aatcatgaat cccaagactg tcggcaatat 1861801 aatcaaacga accgccttct gacagcgtag cagaagaaaa gatataagga attttcttag 1861861 aaaacacttt ttcgccaagt acttctgcta ccgttctcgg catcacgaca aaggttgatt 1861921 ctgcttcctt tttctccagc cagctgatcg catccttttg atatagagat aatgaatacg 1861981 ccatttgttc aacatattct tccactactg acagttcgta ttgatcaatc gtatacattt 1862041 cagactcaaa tacaagtgcc tcaccgattt tatcaagtaa acggcaaagc tcgtccgccg 1862101 cctttttgac acgatggtca ttttttattt ctaaacggtg tgaaccggct acttcctttg 1862161 attcttcaga aagaacatag aaaaattcgt cgtttgcgag aagcgcatct tcaatcaatt 1862221 ctgcaaactc ttctctgatg tcattttgca gcaatcgttc taaaaacaat tcaagagtag 1862281 actgcttcac tctataggtt agcgcttttt gcgcagcaaa ctctaacaag tgcccctcat 1862341 caaatacaac tgcactatga tcaggcaaga gcggcagctg gccctctcgt ttgcgtgatt 1862401 cttccgtcca cacatgctcc atataaaaat catgggaaca aatgattaag tccgttgact 1862461 tgcggtagta atctctggaa agtgtcagac cgcatctgtg tctcatatca caagtcagac 1862521 agtcctgaaa cgagtcgtag cttacgtcag accactcttc attcgataga tttgcgtact 1862581 gcttacggtc gccatacgga taaaagcgct gcatcgcctg ggactcgtgg acaaatgacg 1862641 gtaacgactc ataaagatcc agccatttat catcatcaga acgctgcatt gttttttcaa 1862701 gcttcttcaa gcataaatat tgctcatgtg attttgacag ccttgtatca attttcagat 1862761 caagatgctc agccagctta gaaatatcgc cctctttttt caccagctgt tcaattaatg 1862821 tttcatccgc acaagcgatg atggcaggtt tgccgacata ccttgcatag ctgattgcaa 1862881 aaagaagata taccagcgtt ttccccgttc ccactccagc ttcggcgaac atgacttttt 1862941 tctctttaaa cgcccgctcc agctgaaaag ccataaatac ttgctcgtcc cgaagatcaa 1863001 accctttttc gggaaggata tcgtaaaaca cgtcaccaat ccaattgttc aattcttcat 1863061 aaaaattctt tgttttcgtt aaagaaaaag gcaaacgtga tgttgtcacc tagttccaac 1863121 ccccaactat tcgacattca gaccaccaat aatatcattt tccgctgatg aatacaataa 1863181 aaaacttggc aatgccaagt tttttgcagt ttacttacga ttgatcacat gcgacgataa 1863241 aaaaggatgg tctgttgaat aaatatgttc taccgctttt tctaaatcag tttgcgcatg 1863301 cgaaatcaca gacggagacg aatcagtccc gagctccttc agctcgtttg ctgttgcgtc 1863361 aagcgccctt tgaataagat taaaatgttc gctgttcagc atgagatcac ctctgatgga 1863421 aataatcatc attgtatgcg aacttttcat tttatataca tgctttaccg catgttatca 1863481 ccgaaacatg cacaaactac acttgatatt ccgtctccgg attatccgtc ttatcaacaa 1863541 tattctatca gggagtgatg ttgacatgag ttatagaaac cgattagatc agcattctga 1863601 actgtttcat cacaattgga cgcggcctaa acgttcaaag tctcaagtaa acggtcacac 1863661 tgaaatgtcc caaaccaaca ttatattgag aagcaacgcg aaagctcacc gttggtaacg 1863721 atagaatagg gctgaaagat gaaagaagac gcatgcagag cgtcttcttt ttatgcgttt 1863781 tctgttttct tgcgctgcgg tcttactttt gaccagtatt gataataatc cgttttaata 1863841 aacccgttaa agagttttcg tttcttcgtt gcttttctgc catatgcttc ctcaaagttt 1863901 tcatttgatg tcagcatata cacagaccaa gtatcaagcg gctcgaacgc ctgccccatt 1863961 tctttgtaca tctgctcaac ggcttttttc tcgccgagac gctctccata tggcgggttg 1864021 ccgacaatta cgccaaattc cagatttgtg gtaaagtctt tgacctgcat ctgtttgaac 1864081 tggattagat ctcccaatcc tgcttcctct gcattttctt ttgcgatttg aaccatgcgg 1864141 tggtctatgt cgctagcgaa aattgtaagc ggctgatcat aatttgcctt ttcttcgact 1864201 tcaagccgcg ctttgttcca cagatcttta ccgatccatt cccaatcctc tgatacaaaa 1864261 tcgcggttga atcccggggc gatgttttgg ccgattagcg ccgcttctat cgcgattgtt 1864321 ccggagccgc agaaaggatc aacaaacggg cggtcaggcg tccaattggt taattgcacc 1864381 aaagcggcag caagtgtttc tttaatcggc gcaccgccct gatcgacacg gtatcctcgt 1864441 ttgtgaaggc ccgtccctga tgagtccagt gtaatcaaag cctgatcttt caataaagat 1864501 atttccactt tatactcagc acctgtttct tcaatccaat cattggcttt gccggactgc 1864561 agcttgagct tttcgacaat tgcttttttg acgatccgct gacagtcagg aacgcttgca 1864621 agtgttgatt ttaccgattt tccgatgaca gggaatttcc cgttttcagg tataaatgag 1864681 cgccagttaa tcgctttcgt tttttcaaac agttcatcaa atgttttcgc tttaaaagaa 1864741 gcaacctgaa cctttatgcg gtcggctgtt ctaagccaaa ggttcgcacg gcagatggca 1864801 agtgcatcac cttcaaaaat aactttcccg ttatcaacct tgcattcgta tcctaaatct 1864861 cgtacttcct ttgcgacaac agcttcaatg cccatcggcg ccgttgcaat tagtgtatac 1864921 ttcttcatcg tatcaccctg tcttttaaaa cttttctctt ttcaagataa aagctctcct 1864981 tatacgggag agcttgtttt catcatttta aatgtaagtg gtctaacgtt ctgtaagcca 1865041 tgttttgttc catcgtactg caaacggctc atcacctcgt actcaggcgg caatcatcta 1865101 tctacagaaa gcattctgtc cttctctccg ttgaattccg ttaagaaggt tcccctacca 1865161 aaatttgggt ttctcgctcg aggggtttac cgcgttccac tctcaccatt tctagtgaga 1865221 cttcgtcact gtggcacttt caaggatact cagccatatc cgaagacgta ggcttttttc 1865281 ctgccgtcag cctctaaaga ctgccctagc ttatgacttc gctaggcacg aacactacgg 1865341 gcatctcagc accgtgcgag catggacttt cctctacaga ttcaagatct gcagcgatta 1865401 cccgaacgtt aagaacatga attattatat aacaactgat tacaatttac aagcgccatt 1865461 tttttcaagc gtgatcaatc ataaagcttg ctgccaaaaa cgtgtttttc taagttagac 1865521 agccgtttta aaatatcaaa gtttgttgtg ttagattgca caggctgttt tttgctggct 1865581 tcttcaagct gttttttcag ctgcagattt tcctgctgca gttcttcaat ttcttgatgg 1865641 aaggtttcat aatccttaat aatcatatct aaaaatttgt caacgtcttc ttgcttgtag 1865701 cctctaacgc ctgttttaaa ttctttttcc aaaatttctt tcgcagaaag ctttacttta 1865761 tcagcaagca tctttttcac ctcgtatcgt gaatcatcac atatattttt tcagaaatct 1865821 gtacggttgt caaatttctc tctcattgtt agtagctgtc ttcctccact gtcactctca 1865881 agtcatccat tgtaataaag tagatgggat agccatcctg ttcgcgcctt ttttccgctg 1865941 tcccaagcat atacttaggg gagccttcct tttccgggtc atataaaagc agaagcccgt 1866001 cggacttatc aatgaagaac tgattttttt gtttgaattg aagcgggctt tcataaggac 1866061 ggtgagtcag gcttgcttca tagtctgcct gagccagaac tgcttcatac tgttctttat 1866121 tcggttcttt ccagttcttt tcctgctcgt aaaatggtgt gatgacagct acctttaagt 1866181 cagggtattc ctcctgcaaa tcatatgcag cttctgccgc ccacagctca actccaagct 1866241 ggcccgaaat taaaatccat tctaatcctt catccaaaaa agcaatcagc cggtttttaa 1866301 tggctttttt tatgtaatac agcgccttgt catcctgctt aaatatcccc agttcaaacg 1866361 gtttatagcc cgttattgcc aatactttca tcatttcacc tgctttaaaa aatggggctc 1866421 ccgtgggccc catttgttgt gctgcattgt ttacaccatc aagctgcacg ttttccatac 1866481 tagtagtcgc agcaaggttt tcctgcttga aaatgctgat gcgtagccgg gtcaacattt 1866541 gagaaagtgt gtggaaagta gtgaacgtgc tgaaaatgct ggtggtttac gtttgttgta 1866601 tgctgtgggt gaatgtgcgg cacgatagtc ttcgaaaacg tatggtgttc acagcaatga 1866661 gtaggatgga caattggcgc catcatatgc ggtctgcagt gatgcatgat aaaatcccct 1866721 ttccataaac tttattacaa tactaagtta tgaaaaataa ggggtacatg ttctgatgca 1866781 aagacctatt ttaaaagtgt gcaattaagc tgtctttaaa gtttgaaaac acaaaagcaa 1866841 tcaaaaatac cacaacaaag aacaagtaaa aaacaccctt atacatacca actctccctt 1866901 taaaaataac taacgtcatt ttacaggatt cgccgctatt ctacaacaaa atcaatgtga 1866961 attcagcaaa aaaaattcat ggcgaaacaa gtcgtctttt gcgctttccc ggggaatatt 1867021 taagaggaat atttcctctt tagccgggca attctcacat gcagtttttc agtttctttc 1867081 tctgataagc atgccgcatc gctaagcgat tgctctgcta cttgcaatgc ttttccgaat 1867141 tcttttttct tatgctcaaa atatttcgcg agctctatta cagcagcgta tctgcacttc 1867201 tggttttgcg agcgggacag cttttcccaa agcggcactg cttcttccaa gcggttttgt 1867261 tttttgtaca ggagcgataa atccagccgt gcactgtcct ggtcctcaaa cgatttttct 1867321 ataagccttt ccaactgctt gatcgcttgg tccgtttctt tatgagccat aaaccatttc 1867381 gccatagcat aggcttcact gtgttctttt ggcgcatgtg attctgaaag gattttttta 1867441 gacatatgga tgtacaatga aatgagtgat aacacatcca tttcattatg atgcaggaca 1867501 ccttttaaaa gatccggctc ttgcgccttg ataaaatgaa agtaaagcat tggcgccaag 1867561 tagcccggtg tgtcttctag cctgcggatg ccgagctcct ctttttcaac cgtgccaaga 1867621 gatacacggt ccattttgtg tttccacagg cgtctagctc catgcaaaag atcaaagtgg 1867681 ccaaactccg gaagcttcgg aagtctgtca cggatcaagg tgtgccttgt tttcacctgc 1867741 ggccaatcaa aggctttgcc gttgtaggtc acaagtgatg taatgtcaac ctcgcttaaa 1867801 aagctttggt acaaggcgac ttcgttcccc ggtttgggca aaagatgctg tttgactgtc 1867861 actcggtctt catatactct cgcatgccca agcaaaaaaa tggtattccc agctccaccc 1867921 ccaagaccgg ttgtttctgt atcaaagaaa aagaggttgt ttttgttata cccttttgct 1867981 gacaatgtat gcgacaggcc gctttgattc cacagtgtga tcacttcctc aagctcagaa 1868041 aagctgtata acccatggcg gtgagaaagc ggatattcta cttctctgat gaggcaatat 1868101 tcatcttcga agatgaaagg cttcatgcca aaagcctccc actcttctaa aaacgggatg 1868161 tcatcaaagt ggttttcttg tttgcctgct tctatttttt gttctccttc gtcgagcgcc 1868221 atgtgctttt tcatccgttg gagtttccct tttaatgaca tatccggcct ccctccttac 1868281 gacatttgat ccaacagctg caaaattctt tcctttgctt ttatcccttc tatttccgta 1868341 cctatacaag acggacagcc gtcatgacaa ggacaatgtg taatcagttg tttcgccgct 1868401 tcattaatgt ctgaaaaacg tttaaagact tcctccgcca aaccgatacc gcccggataa 1868461 tgatcatata aaaatatggt tggcaatccg gtatgggctg ctttaatttg agaaacaaca 1868521 tgaacatcat ttcgatcaca catgatatac acagggacaa tatgctgcag cacattcgag 1868581 atgccaagaa gcagctgttc cagtgtcttt tccccgatgt cttcatccgc tgttttgatt 1868641 tcgagccaag ctgcacttgt atgcagttct tcttccggca aatgaatagg tccagaccca 1868701 atattttcaa aagtggtcat ttttattttt ttaaaaatgg tcggcagggc attgacagtg 1868761 acgtctccgt agtgcaatga cgtacggctt ttttctttcg ttttatcgat ttctaatacc 1868821 ttcagctgaa ctgccaggtt tgcatccgta taatattcga catcgacttt tctgacatac 1868881 gcctttttat ggtcccaatc gagcttctca acttgatact gaacgccttc atgcaaataa 1868941 atcgcttcat catgcaaaag cgtcatcgca ctaaaacggt ccatttcacc gataatcctt 1869001 acatttgcaa tatccgactg atcaactata acgacatttt cctgggaggc ggaacgcaaa 1869061 ctgatgtttg acgcagggaa cgactcactt gcccaatggt accgttcgcc gttgcggtga 1869121 agaacagcct cttcctgaag atactcaaga atatcactga cttccatggc tccaaattct 1869181 tcatcagctc taaaaggaag ctcataagcc gcacacttta agtggtctac taaaataatc 1869241 aaattctccg gattgattct tgcagattcc ggcgaacgat taaagaaata ttcaggatgc 1869301 cgcacaatat attggtcaat cggtgttgaa ttggctacca tgataatcaa agattcaccg 1869361 tgtcttctgc cggctcgtcc cgcctgctgc caagcacttg caacacttcc gggatacccc 1869421 gtcattacac acacttgcag ctggccgata tcaacaccaa gctctaaggc attcgtactg 1869481 accactccta aaatgtcgcc ttctctcagt cctctttcga tttctcttcg ctctttcggc 1869541 agatagcctc cccgatagcc tctgattgat tttgttccaa tctctttttt cacaagctcc 1869601 tgaatatggc ttaaaataat ttccacccga actctgcttc tggcaaaaac aatggtctgc 1869661 actttgtttt taaggaactc tttcgccagt tcattcactt ctgcggttgc gctccttcta 1869721 atattcagcg gtttgttcac aattggcgga ttgtaaaaca caaaatgctt gcgtccgctc 1869781 ggtgcgccgt tgtcatcgac cagccgcatc ggtttgcctg tcagctgctc tcccaattcc 1869841 tttgggttgg caatcgttgc ggaagtacaa ataaaaactg gatcacttcc ataaaaccgg 1869901 cagatccgct tcagccgccg gatcacattt gccacatggc tgccgaacac acctcgatac 1869961 gtatgaagct catcgatgac gatatactta aggttttcaa acaaactgac ccatttcgta 1870021 tgatgcggta gaatggcaga atgcagcata tcggggtttg taatgacaat atgacctgct 1870081 tttctcacct tttgtctgat tgccggagac gtatccccgt catatgtaaa gcttttaata 1870141 tcaatgccca tttcatcaat aatttcattt agctcgctct tttggtcttg tgccagcgct 1870201 ttagtcggaa ataaatataa cgcccggttt gtttcatctt gggcgatgga ctgcaggact 1870261 gggaggttgt agcataacgt ttttcctgat gctgttggcg ttacggtaac gatgctctct 1870321 cctttttgca catattgaaa agcggaatat tggtgagtat atagttcatc aatgcccctt 1870381 ttcgaaaggg ccgctttgat tctctcgtct atactttcgg gcataggcct tgtttttgct 1870441 tcccgaggct caatttcatg ccaattcaca acgttttcat ttccttttaa atcagaaatg 1870501 agttcagtca gtgatttctt tttcattctt tacacctctt tgtcaagtac agtttaccga 1870561 atatttgttt gcatggctag gtgcaaattt tatacagttg aataaaaaaa gcaaggcata 1870621 cgccctgctt atttcgcttt tattgtaaag agctttgatt cgcctttacg agcagccttt 1870681 tcgcctgccg ataccattga tcctacagcc tcaccattca ttataacgat tgggatgact 1870741 gtgctgctcg ctttttcttt tattaattcc aaatcacatg taatcagcgg gtcaccgacc 1870801 ttcactttat ccccttcttt aatgtgggca gtaaatcctt ctccgttcat attgactgtc 1870861 tccagcccga catgaattaa cagctcaatt cccgagcgag tccgaatgcc aacggcgtgt 1870921 ttggtgtgga aaatctgaat gacttcacct tcagcgggag aaacgatttc accgctagaa 1870981 ggttccaccg ctattccttc tcccatcatt ttctgtgaaa aaacagggtc cggtacatct 1871041 gacaggtcca ttactgtacc gtctgccgga gaataaataa cctcttctgt caccttttcc 1871101 tgaattttgc ccattccgaa taattttttc agcaatgtat tttctccctt ctcattcact 1871161 tcaaccgtta tcccttcatt caccactatt taaccacact ttcaattttg cttcaattta 1871221 taacaacatc tggcatagac gcataatctg gttaaaaaag gcggtggcga tattggaatt 1871281 ccatgatgac aaaaagaacg aactgcaaaa gaaagaagaa atcataacgg aggcaatcga 1871341 cactcttttt caatcctcag cgttcggcaa ccttataaac ggatttcaga acctaatcaa 1871401 ctcgagttta aaggatgtgc agacgaccat acatgtcaga gaaagagata ctgggctgta 1871461 tatcgatatt accattccgg cgacgtttcg agatggcgag atcgtcgttg atgttaaatc 1871521 gaggtatctc catgtaacac tccaagaaaa acagaaacac caaaatgagg ctacctttac 1871581 aagcatgaca agaacggttc agctgcctta tgaagttcgc caagaagata tggaaacgtc 1871641 ttggaacgag cagacaatga cacttttctt tccaaaaaat aagcatgaat gaacgattca 1871701 ttcatgcttc tatcatttaa aaaagctggt aaatcccttt attaaagatc cgacctgatt 1871761 cattgcactc attacttgac ctgtcgtatc catcatttta ttaaaatcaa attgcccatt 1871821 ggcttttttg aactgcgaca taatgctttg aaattgtgaa ggctgctgtt gattaggcct 1871881 tgggatagga taagggttag aaaatacagg cggctgcata ggcataggct ggatcggagc 1871941 ataaggctga taataatcct gctgtccata atgctgctga ggcagttgtt gctctaaata 1872001 accgggtgca gcctgctgat aatatccttg catatgctga ggataataat agcccatttg 1872061 ccgaggatag cttcgagagc tcccgttcat tgcgattccc ccctaaacac aacatatttc 1872121 tcttctatat atgtatgaat gacttctatt gtttgtgtca caagtgatga ttagcatttg 1872181 tcaaattgtg tcgaaagttt aaatttttta aaaacagaaa aaagtcgaat cattatggta 1872241 ccatattttc aatacagatg agaggggatg caccataatg aacgtatcat acttaagcaa 1872301 acgttttgca gaaatgaaga aatatgaaac agactgtatg aataaactga tggactttgc 1872361 caagttcctc tatattcaag gacatctcag cataactgag tttcgtaaca gtatgaaggt 1872421 tctcgaagca aatggagcag aaagcccggc atatgagatg aattaacgtc cggcccccta 1872481 taaaaacgaa aagaagacag ccttttaccg gctgtcttct cttgcaattt catcctttac 1872541 tgcgtgcaat gtataaagga ctgactcagt gatgtccttg aatcgttttt tatgaatatg 1872601 atgaacataa gattgaagga ccaattccag gaaattatcc tttacggcct caatttgctc 1872661 tttatgcaca tattttggcc ggcggacttt tatcaattca agagcaccct ctgcccagcg 1872721 agcagccagt tcatcattct cttcaactgc aggctttatc gtctcaaaaa aatcataaga 1872781 atgattactg ttttttcctt cctgataccg atcagcgcct ttttcagcaa cttcaatcat 1872841 ttgctcggtc atttccagca aagtttgtga tagcaatatc tttcacctca atgcctatcg 1872901 taccaaattt cactcacaaa ttcagccgat gcggtatacc ttctcaaacg catacctgtg 1872961 ttcaggcgat tgatacagct catttataca aatatgaaga tctatgattt cttcttcgag 1873021 cacacttagg cgatcgttct ccgtttcccg catctcagcc tctaatgcat ttacagaatg 1873081 attcaggctt tgctcagctc gcgttaattc atcttctata tcagaaagca tacggagaat 1873141 atctgtcttg catacataac cggacattcg tgtacctccc tttccttgtc tctcccggtt 1873201 aacattcttt gctctcaagg ctctttcctt cctcatgaca aaactagaag caaatcgcca 1873261 aacaaacagg tattccacga aaagctgaag ttttcgacaa aaacacccgc aaaaattgta 1873321 tgatcctcct cattaatgca aacgatactt gtgaggaggt gccgtatgaa aacaagaccg 1873381 aaaaaagccg gccagcaaaa aaagactgaa tcaaaggcaa tcgattcttt agataaaaaa 1873441 ttaggcggcc cgaaccgccc ttctacgtaa gaagcaagga atttccttgc ttctttattt 1873501 tttcagccac tgctccaccg caaaaagcgc atgaagctgg cgctttttat gtaaatacca 1873561 gtctgtcaat tcaatctgct tcggcaattc ctcgcgccta aagaacgttt tctttatctt 1873621 tccatgaaac caatctgttt tcgttccgtc taatgagtgg attaactcag ggtagcatgt 1873681 ccttagcata ggagatgttc tttttgtaat cccgatcatc ttttccatat caaaacggga 1873741 acctgtgtgc ggcactgtgt gcaaaaagtg ataaaaagag gagaacaatt ctggcttgaa 1873801 cagcaattga gacagctgct ttcccagcct tatcctttcc tccgcctttg aaaagcgttt 1873861 cactgaaatg ccgtaaaaaa acccatttga ggaaggaaaa ataacggtgt taaaatgaaa 1873921 ccagtcactt aaataaaaag gaatcgtgtc aaaaacattc tttttaaacg aaggattttg 1873981 tataataggt gtttggatag tgttttgttc atttataatg agggcataca ttagccgctc 1874041 cgtatttcgc tcatgccaaa aacgggtcca ttcttccgac ataaattgtg agacgccaaa 1874101 cacatgcagc agatgaaaca gcggtttccc aactcttttt gaccagtggt ataaaagaag 1874161 ctgcggatag gcatccgaaa aaataagcca gttcgctctt tcataggcta aaaagaacca 1874221 tttttgctgt ctctcacgga gtccaagctg aaacagactg ccttttaagt cagtcattga 1874281 ccagccggca ttacgagaaa cgaaagaagc caaaagcgac catttgattt ccggatgacg 1874341 gtcgtaaaat gctttataag catttgttct tgaaatgtta tccgcgtttt tcatttttgt 1874401 ctgccgctca atccggctca gaagctttct gatggcctgt tgttcttgca cgttcattca 1874461 cttccgtcat gattagttta ataaggagga tgagaaagtg attcggtatc ctaatggaaa 1874521 aacatttcag ccgaaacatt cggtttcatc ccaaaacagt cagaaaaggg ccccgtctta 1874581 cagtaatcgc ggaatgaccc tcgaagatga cttaaacgaa acgaataagt attatctgac 1874641 aaaccaaatt gccgttatac acaaaaagcc gacacctgtt caaattgtaa atgtccatta 1874701 tccaaaaaga agtgccgcag tgattaaaga agcttacttt aaacaatcat cgacaacaga 1874761 ctacaatggg atttacaaag ggcggtatat tgattttgag gcgaaagaaa cgaaaaacaa 1874821 gacctctttc cccctgcaga attttcatga ccatcaaatc gagcatatga agcaggtaaa 1874881 ggctcaagac ggtatttgtt ttgttattat atccgctttc gaccaggttt attttttgga 1874941 agccgataag ctgttttatt tctgggacag aaaagaaaaa aacggcagaa aatcaattcg 1875001 aaaagatgag ttggaagaaa cagcttatcc gatttctctt ggatacgcac ccagaattga 1875061 ttatattagt attattgaac agctttattt ttcgccatca tctggtgcga aaggttgatt 1875121 aacgaaaggt tgagatgtta tgtcagatca atttaacagc cgtgaagctc gacgaaaagc 1875181 gaacagcaaa tcgagtcctt caccgaaaaa aggcaagaaa cgaaaaaagg gcggattgtt 1875241 taaaaagacc cttttcactt tactcattct gtttgtttta ggcgtagtcg gcggtgctgt 1875301 tacatttgcc gtcatggttt ctgatgcgcc gtcccttgat gaaagcaaat tgaagacgcc 1875361 ttattcatca acgatttatg ataaaaatgg aaaagagatc gccgaagtcg gcgccgaaaa 1875421 acggacctac gtctcgatag atgaaattcc cgatgttgta aaagaagcct ttatcgcgac 1875481 agaagacgct cgtttttatg agcaccacgg gattgaccct gtccgtatcg gcggtgcatt 1875541 agttgccaac tttaaagacg gcttcggggc tgaaggcgga agtacgatca cccagcaggt 1875601 cgtcaaaaac tcccttcttt cacatcagaa gacgttgaaa cggaaggtgc aggaagtatg 1875661 gctttcgatt cagctggagc gcaattactc taaagatgaa attttagaaa tgtatttaaa 1875721 ccggatttat ttttctccta gagcatacgg aatcggaaaa gcggcggaag aatttttcgg 1875781 cgttactgat ttaagcaaat tgactgtcga acaggctgcg acgcttgcag gaatgccgca 1875841 gagcccaaca gcgtacaacc cggtcaaaaa cccggataaa gcggaaaaac gacggaacat 1875901 cgtactcagt ctgatgaaaa agcaaggatt tatttctgat tctcaatata acaaagcgaa 1875961 aaaagtggca gtgaaagacg aaggcgtcgt gtcacagaag gaatatgaaa aagcaagtac 1876021 aaacaaatac agcgcatttg ttgaagaggt tatgaaggaa attgatgaaa aatctgatgt 1876081 cgatccatct gctgacggat taaagatcta tacgacatta gatacaaaag cacaagataa 1876141 actagatgaa ttaatggacg gagacaccgt cggatttact gaaggcatgc agggcggtgt 1876201 gacgcttctc gataccaaaa acggagaagt ccgagcgatt ggtgcgggac gcaatcagcc 1876261 tgtcggaggc tttaactatg ctactcaaac taaggcacag cctggttcga ccataaaacc 1876321 gattttggac tacggaccag ttattgaaaa taagaaatgg tccacatacg aacaaattga 1876381 tgactcagct tatacgtatt ctaacggaaa accgattcgt gattgggacc gcaaatatct 1876441 agggcctatc tcaatgcgtt acgctctggc ccaatcaaga aatatacctg ctttaaaagc 1876501 attccaggca gtcggtaaag atactgctgt agactttgca aatggactcg ggcttggttt 1876561 aacaaaagat aatgtaacag aggcctattc tattggcggt ttcggtggga acgatggtgt 1876621 ttctcctctg acaatggcag gtgcatacag cgcgtttgga aataacggaa cgtataatga 1876681 accgcatttt gtaaaatcta tcgaatttaa cgatggcacg aagcttgact taacaccaaa 1876741 atcaaaatca gccatgagtg attatactgc gtttatgatt acagatatgc tgaaaacagc 1876801 tgtgaagaca ggtactggac agcttgcaca agtacctggt gtagaagttg caggaaaaac 1876861 aggaacgact aactttgatg ataatgaagt caaaaggtac aatatcgcta gcggtggcgc 1876921 ccgagattct tggttcgttg gctacacacc gcaatataca gctgccgtct ggacgggaat 1876981 gggagaaaac gaggctggaa agaaatcact ttcagctgaa gagcaaaaag ttgcaaagcg 1877041 catcttcgcc cagctcatcg ccgatgtcga tgacggaagc ggatcatttg agaagcctga 1877101 cagcgtagtg gaagccaccg tagaaaaagg ttctaatccg gcaaaactgg cagggccaaa 1877161 tacgccaagc gataagaagc tcacagagta ctttgttaaa ggcacagctc cttctactgt 1877221 ttctaaaaca tatgagaaag aagaaaaaga ggaaacagct aaactgtctg gtttaaacgt 1877281 gaaatacgat aaagacaatc aatctttaac gttaagctgg aattacgacg gagatgcgac 1877341 ctttgctgtt aagcaatctg ttgacggcgg cagctactcg gaaattcaaa acagctctgc 1877401 aaaagaggca gttatttcgg gtgtgcagcc aggatctgta tacaaattcg aagtaacagc 1877461 cgtcagtgat gatggcaaaa gtacagcttc cacatcttat gaggtgccaa aagctgaaga 1877521 cgatgaagat aaaaaagacc agcaacaaac ggatgatgaa aaacaagatg atgagaagac 1877581 tcaggatgat acacaaactg atgattctca aaaagatgac ggtcagacgg atcaagatca 1877641 gacagatgat tcaacaaacg atcaagacaa aaaacaagac aatacgaaca ccaatccgtc 1877701 cgacaacaat aaccaagacc aatcaaacga taatgataac gacaacagta acaaccagga 1877761 tacgtcggat ggtgattcga actctggtaa gaatgattca acaggttctg acacgaataa 1877821 aaataaaaca gacacatcta ataaaacaca aacaaactca tcatccattg aaaaaacaaa 1877881 ttaaacaaaa aagccgtcac ctttggggtg atggcttttt tggtacacaa taaaaaacct 1877941 cccgttttaa caggaggttt tatcgattca tcgcatgata tttataaaaa tgctttttca 1878001 tttcggtaat cagctcatca agctgaataa agcaatggta ttgggtcggc ttaagaagaa 1878061 taaattccac tcgttcagcc caattaatcg gctttgcggg atatgatttc tccctcagtt 1878121 cttgccaatc gagcgatttc accggctcac ctgctgtcca atgtaacgaa gccagcaaac 1878181 acacaatgcc ctttaacatt tcgttttggt cacatctcga ttttcgtgtt tgaaagactg 1878241 ggagaagtga tgctttgatg tcatcccaca cttcaaataa aagcggaacg tatttcccgc 1878301 tgtcctccca tggcaaatcg ccttgtaatt ccgtgcagaa atcaaaatac acgggattgg 1878361 tctgcaaggt tttcttcata tccgaggaac tcttctggcc aagactgcgc aagtattgct 1878421 cataggaagc caacacttct tttgcttgcg tcatcgtttc accagtcctt ttttatccct 1878481 cttctgccct tctctgcaca aagaaagcag cggacactcc gcacagcgcg gagattgggc 1878541 tttacagtga tatctgccga agaaaataag ccggtgatgc gtaacggacc aatcttcttt 1878601 gggaaccttg cgcatcagcg tcttttcaac ttccagaacc gagtccttcc accggcaaat 1878661 gcccaatcgt ttgctgactc tctccacatg ggtatctacg gctatggccg gcacgccaaa 1878721 cgcaacggat accactacgt ttgcggtctt tctcccgacc cctggcagtt tgacaagctc 1878781 atcgcggtct ctcggcactt ctccgccgta atcttcaata atcattttac tcagcttttg 1878841 aatatttttc gctttattac gatataaacc gattgattta atatcctgct gaagctcttc 1878901 cagcggaaca gccaaatagt cttccggccg tttatatttt tggaataatg ttttggtcac 1878961 tctgtttaca agtgcatctg tacattgcgc agataaagca acagccacca ctaattcaaa 1879021 aggattggaa tgaaccagtt cacactccgc atgaggaaac atgtcaccta tcttgtctaa 1879081 acagaattca atttgtttta gatttaacac gattgtcacc ttttcacttt attgttcaag 1879141 ccaattgtaa aaaggaacct gccttttata ctctttttgc ggttcattct gctttgcttg 1879201 tacacgccgg aatttttggc tgtgtatttt tgcctgctcc acagttttaa gcccattttt 1879261 cttccattca aacaaaatcc ggtcaatgta gcggaaactg agttttcctg atagtacagc 1879321 ctcttttaac gcgtgtttga tcagttgtgc gtcatgctga tcctggtcct gccagatcgc 1879381 cagcgtttca cactccaaag gcgataacgg tcttgcgaac tcttcctcaa aaatggtata 1879441 aaggcttttt tgttcccctt ctgcttttct ttcctgtgtt tgattctgtg caagctgaat 1879501 atactcgtac agcttgcccc ataaaggctg aagagaatat ttctcaaatt tgatgccgtt 1879561 ttgatcctcg cattcttcaa taaacagaaa gcctttttga ataaacatcc gcaatctgtt 1879621 tgtacattct tcaacagaaa ttgacatacc ttcctgcagc tgattcggtg taggaaaata 1879681 tgatcctttt tctaaatgca ttttaatttt taacagcaga ataagttctg tttcattaag 1879741 cccaagctgt ttataatgcg tgagcagaag attggggatg gttgatgttc cctgctcctg 1879801 catatcaata aattgctgtt ttttcatcgt cacacctctt actgtaaagg attgtgattg 1879861 cccctttact gtaaaaagtc tcccttgcag gagactcttt tttgtttcat ttgaatgtat 1879921 tacggataca gacggtttaa cagtcttggg aacggaatcg tttcacgaac gtgaggcgct 1879981 ccgctgatcc aagctactgt ccgctctaat ccaaggccga agccggaatg aggaactgat 1880041 ccatattttc taagttcagc ataccattta taagcgtcag aatccagtcc atgttcttta 1880101 agacgcgatt ccaaaagttc catatcgtga atccgttcag acccgccgat gatttctcca 1880161 tagccttccg gcgcaatcaa gtcagcgcaa agcacaacgt cctcacggtc agaagccggc 1880221 tgcatataga acggttttaa ggacgtcgga tagcgagtga tgaataccgg tttgtcataa 1880281 tgttcagcaa tcgctgtttc atgaggcgct ccgaaatcat ctccccactc gatatcgtca 1880341 aagccttttt ctttcagaaa ttcaatcgct tcatcatacg taattcttgg gaacggggct 1880401 ttgatttgct caagttttga cgtgtctctt cccaatgtgt ttagttcaat tttgcaattt 1880461 ttaagaactg attgcacgat gaaagaaacg taattttcct gtacttgaag gttttcttca 1880521 aattctacaa acgccatttc cggttcgatc atccagaatt cgattaagtg acgctttgtt 1880581 ttagactttt ccgctctgaa tgtcggtccg aaagagaata cttttcctaa agccattgcc 1880641 gcagcttcca tgtagagctg tccgctttga gacagatatg catcttcatc aaagtacttt 1880701 gtcgcaaaga gttctgttgt tccttcaggt gcgcttccag tcaaaatcgg cggatccact 1880761 tttacgaagc cttcgttatt aaagaattcg taagtcgcgc gaatgatttc attacggatt 1880821 ttcatgatcg catgctggcg ctttgaacgc agccataaat gtctgtgatc catcaaaaat 1880881 tccgttccgt gttcttttgg tgtaattgga taatcggtcg cttcgtgaat gacttcaata 1880941 tctgtcacag caagttcata tccaagcgga gaacgctcgt cctctttgac aatccctttt 1881001 atatagagcg acgtttcctg cgtcactgat ttagctgttt ggaaaatgct ttcttccact 1881061 tccgctttta ctacgacacc ctgaataaaa ccggtaccgt cccgaagctg taaaaacgca 1881121 attttcccgc ttgaacgctt attagcgacc caagctccga tcgttacttc ctcacctacg 1881181 tgcttgtaca cttggttgat tgttgttttc aacatatttc cctccaaaac aagaaagaca 1881241 ttcggaagct cattgccccg cgaactcttt tatcatcact ttattatacc cgctcttaac 1881301 taaccgggtc aatgcagata aaaagcggct tttctgtcag ccgctttttg atctgttagc 1881361 tatgtttttc tacaaaacgc ttgattcttt caatggcttc ttcaagaaga tctaacgatg 1881421 ttgcataaga aagacggaca ttctcaggag agccaaatcc ggatcctgga acaatcgcaa 1881481 ctttttcctc ctcgagaagc gctttaacaa attcatctac atctttgaaa ccgcaagatt 1881541 gagctgcctc ttttgcattt gggaacaagt aaaaagcacc ttccggcttc acgcagctga 1881601 accctgggat ttctatgagc tttgcataga tcgtatttaa tctatgttca aatgcttctc 1881661 tcatttcttc caatggctca gaaggcccgt tataagcagc aatcgctccg tattgtgcga 1881721 ttgatgtcgg gtttgacgtg ctgtggcttg caaggttcgt catcgcttta ataatgtctt 1881781 cagagcctgc cgcataaccg attctccagc ctgtcatgct gtgggacttc gatacgccgt 1881841 ttataatgac cgtttgctct ttcagtctgt ctgacagctg tgcaatggaa acatgtttct 1881901 ttccgccgta tgtaagtttt tcataaattt catctgacac aatcaagata tcatgttcaa 1881961 ggcacacttc accgagcgca gatagttctt cttccgtata catgacacca gtcgggttgc 1882021 ttggagagtt aataacgatt gcttttgttt tttccgtaat tgcatttttc agctgctcag 1882081 gcgaaatttt gaagtgattt tcctcaagcc cttctacata aacaggcttt ccgccagcga 1882141 gtttcacctg ctccgggtag cttacccagt aaggcgttgg aataataact tcatcttctt 1882201 catccaaaat cacttggaaa agggtataca gagcatgttt ggcaccagtg cagacaataa 1882261 tttgagacgg tttgtattca atattctggt cgcgtttaaa tttctctgca atgctgtttt 1882321 tcagttcagc caaaccaccg gaaggcgtgt atttcgtatg gccctcgttc atcgaacgca 1882381 cagcggcatc aataatatgc tgcggtgtat tgaagtcagg ctcgcctgct cctaagccga 1882441 tgacatcatg gcctgcggct ttcagttctt tcgctttcgc tgtgattgcc agtgtggttg 1882501 atggtgttaa tgcggatact ctttttgcca gtttcaactt gaactccccc taattcgtct 1882561 taaggcgtga tatttttgag aatctttcca gttgtaaagt ccacataact taaactgtat 1882621 tgcccttctt tgtctaagta cgtcacttcc caaagcagga cgtttccttc tcttgccaga 1882681 tgaacctctt tttgctttga aaccagccct tcatccttta tgattttcgc cgctttgtct 1882741 tcagagattc cctctttcgc ttcttttgag agaatttttg cttttttatc agcaggaacc 1882801 cagacatata atgcagtgcc ttttttatcc gttcccttta caacataata tttttctttt 1882861 ccgacaaatg tttcgacttg atcaacatgg gcgagatcgg tttctttttt agcttcagca 1882921 gctgctgctt cgtgcccctc ttccttttgt gccatggctg atttataaat gcttgccgag 1882981 acaagaagta ctgctaaaaa aataatacca aaaatgacgg taaatattaa tgcttttttt 1883041 ctcatcttct cacctacgta cgataaatgg taaaaacggc ttggtttttg ttttcttcat 1883101 ccagcgcaag gccgaacatc agattgtctc ttttcagtgt acgattcaat gtgtccacaa 1883161 ttttatacag atcatcagaa tgctctacat taattgttga aagaatttcg attttacttt 1883221 ccattttttc atcctccagt ttgaacaaat attgttagtc atactccatt tcaggacacg 1883281 ccatactagt atcacagagc gggaaatccg cttttaaata aaacaccatc ctactcccac 1883341 accgcaaaag ccgctttatg cggcttttat tctttttccc ctgcaacata agcttcaagc 1883401 tcgctgtcag tcatttcgga tactgaggtt gtcggcaagg catcaagaaa cagccggccg 1883461 taaccagcgg ttttaatccg tctgtccaat ataataatcg ttcccttgtc tcccgcagaa 1883521 cgcagcaagc gtccgattcc ttgcctgaag gtcagcacag cttccggtaa tgacactgtt 1883581 tgaaacggat tctttccttt tttgcgggca agctcacatt ttgcagcatg aagcgggtga 1883641 tcaggggacc ggaatgggag cctcacgatc attactgtcg tcagctcatc accagggaaa 1883701 tcaacgcctt cccaaaaatg atttgttccg agcaggatcg cctgattgga tgttttaaaa 1883761 gtcttcatca gtttgccggg acttccgcct gtaatccctt gtgccaagag ctgaatgccg 1883821 gaagcactca tgttatgctt aagctcctgg tgaacctttt tcagcatatc atgggatgta 1883881 aacagcacaa ggattttagg ctgtttttcc tttgccatca gttcgatata acgggctgta 1883941 tcctgtataa attcaggttg ccctgtatcc tgaattgatt tcatttcttt tggaatcatc 1884001 acctgcatac gctcatcgta agaaaagggt gactcaattc tcattgtccg cgggaaaaag 1884061 tcactcagtc ccagtcgttc aatcataaat tgaaaagaac cttcgactgt aagagttgca 1884121 gatgtcagca ccacactatt tttgcgcgcg aaaaactgat cagccagaag ttcaccaggt 1884181 tcaagaggct gtgcgtaaat ggccactgca tttttcgcac cctttgcatc tatttcaatc 1884241 caaaccgctt catcgtcatc agagccaaag aagagcttct gcaacgtctg acagtaatgc 1884301 tgcaagcctt tcatgcttct ttggtattca tcggctaaaa agacggtttt gctcttcatg 1884361 cccttcaaat gtttttccat aagggatgac tgcgcctcaa aaagctgctg caaatgtgtc 1884421 agcatggaac aaagcctctc cgcaccatct gttaagatcg accagctttt atcctggctt 1884481 tctttgttca ccttaaacac tagacggttt aagtcttctt taggttttct tcgtttgaca 1884541 aaagaatgta cagagctaaa gaaagcatca ctttctgctt gaacgtgctg aagccactct 1884601 tccaattcga aaaatgaatc aaccggcagg ctgtttcgct ggaatagctg tctcatcttt 1884661 tttagaagtc cctgctcctt cagagtgccg attctgctca atttcgtatg caattctatg 1884721 tacgtggctc ttttccctaa atgttcgctt gccgcacgtt caaaatggtg tgcttcatca 1884781 ataataaatg tgccgctttc gggaagcctt tttttatggc tgccttcatc ggtcagcaaa 1884841 agagaatgat tggtgatcac caaatcggaa cgcatagcaa tctgtttggc ccgctcgtaa 1884901 aaaccgatca catgctcact gcgacttctt ttataggagt catcgtcata agccaatctg 1884961 tcccacagca attttccgcc tgaaggcaaa ttcagttccg ctacatctcc tgtatttgtc 1885021 tctgtcagcc aaacaagaag ctgtgccttt gtcagtacgg catcataatt atcatcttct 1885081 tcatgaagca cctgctcaaa tttatacagg cataaataat gcgattgccc ttttaaaatc 1885141 gccgctgtta ccggaaatgg aaacagatct tggacaatcg gcaaatcctt tgtgagaatc 1885201 tgctgctgta aaagcgtcga atacgtgctg attatgaccg gcttttttga tttcttggca 1885261 aaaagcgcag ccggaataag atagccaatc gtttttccga tgcctggagg agcttcaatc 1885321 agcgcatgct cacgattggc aaacgcatca gccacctctc tcatcatcat catttggccg 1885381 tctctttttt catacccagg cattaactct gacagcgctt tttcatttcc cgcttcccag 1885441 ctttcgatct caaatgagaa gttctcgtcc tcatttatac gaacatcgat agcttcaggt 1885501 tctctgacag aaaacgaaga aaagcgcgta tagcccggta tctcggtatg tctgttttca 1885561 ttaatgaaca tatccaacaa atgcgtcaga tcactgatga aatgctgcga aagccttctt 1885621 aactgcttta atgtcggata aggaagctgc cgcagctttt caaggatttc caaaaaaata 1885681 agccctgtca cttcagcatc gctgtcagcc cggtgcggct gatcatgccg cagctgaagc 1885741 tcctcgctta attccgtcag cttataccct tcaaatcccg gaaaaacaat gcgtgagagc 1885801 tcgacagtat caagcacttc acaatctggg agctgaaagc ccgccttatg tagctcatac 1885861 ttgacaaatc caaggtcaaa atggatattg tgggcgacaa aataagcgcc gtcaagcaat 1885921 tggaatactt cttcagcaac tgcttcaaat ggctgttcat tctcgaccat ttgattagag 1885981 attccagtaa gctgctcaat aaaagcaggg attgatttat ttggattaat gtattttgaa 1886041 aaccgctcag taatttgtcc attttcgatt acaaccgctg cgatttgtat gattttatcg 1886101 cctttcttcg gcgaattccc tgttgtctct acatctataa caacgaaccg ttgcttattc 1886161 attaaaatgg acacctcaat tcttgcatac gacaaaagtg taacacgttt tgtacggaaa 1886221 tggagcggca aaaccgtttt actctcaaaa tcttaaaaga aaacccccga taaagggggc 1886281 ttttcttcta caaaattgta cgggctggtt cgttccccag catttgttca attttgtttt 1886341 gatcattcag aacagccact ttcggctcat ggcttgccgc ttcttgatca gacatcattt 1886401 tgtaggaaat aataatgacc ttatctcctt cctgcacaag gcgtgcggct gcaccgttta 1886461 agcatatgac gccgcttccc cgtttaccag gaataatata cgtttcaaga cgtgctccat 1886521 tattattatt cacaatttgt actttttcat taggaagcat tcccacagca tcaatgagat 1886581 cttcatcaat tgtaatgctt cccacatagt tcaggtttgc ttccgtaaca gttgccctgt 1886641 gaagtttgcc gctcatcatt gttcgataca tattatattc tctccatttc tcgaatatca 1886701 ataatgatat tatctattaa acgcgctttt gaaaaagcaa ctgcaacagc gagaatcatc 1886761 tttccagcaa tttcattcac aggctcgagt tccggatagg aataaagctc tacatagtct 1886821 atggttccgc tagtcgtttc aatgatatct tttgcagctt ttatcaccgc ttcaggatct 1886881 ctttcaccgg cttggacaag ttccgcactt gtttgaaggg cccgatacag cttaggcgct 1886941 tcttttcttt cctcagctgt taagtataca ttgcgagagc ttttggctaa gccgtcttcc 1887001 tctctgaccg tatcgacagg aaccaattca atatccatga agaagtcgct gattaaccca 1887061 tcaacaacag ctacctgctg cgcatctttt aaaccgaaat aggcacgagt cggcttgact 1887121 agattgaaaa gcttcgtcag tacgatcgcg accccgtcaa aatgtccttc tcttgagcgc 1887181 ccgcataaca cgtctgtgcg tctttctaca tgaatcgtga cattcttttc accgggatac 1887241 atatcatgag catctggcgt aaaaagaata tcgactccgg cgttttctgc aagagctgca 1887301 tcccgctcaa tatcgcgcgg atatgcttca aaatcttcat tagggccgaa ttgtgcagga 1887361 ttcacaaaaa tactcataat aacggcgtcg ttttcttgtc ttgctttgtc tgctaaggtt 1887421 aaatgcccct catgcagaaa ccccatcgtc ggaacaaatc cgattgactt gccctctgaa 1887481 tggtattgtt ttatggcttc tttcagctgt gaaatatcag taatctgtct catcttattt 1887541 tcccccgtac aagccgtcaa gcactgtctg gttcatttga aaggaatgct tttgttcagg 1887601 gaaagcacga tgtcttacat cctgaacata tccgctgatt gctgtttcga tggtttcatc 1887661 aatgcgcgta tattgcttta caaatttagg tgttctctca acaccgtggc cgataatatc 1887721 atgataaacg agaacttgtc cgtccgcttt cacaccagcc ccgattccaa tgaccggtat 1887781 gcttagcgtc tcggcaattt tggctgtgag ttctgccggc acacattcca gcacaagcat 1887841 catagctcct gcttcttcgc attttatact gtcttctatt aattttttgg cgctttgttc 1887901 gtctttgccc tgtactttat agccgcccag tacgccgact gactgcggtg tcaaacctaa 1887961 gtgactgact actggaatgc ctccaagcgt caatgcgcga atggattcaa acacgccttc 1888021 tccgccctca agcttcagtg cgtcagctcc gctttcctga acgatagccg ctgcattttt 1888081 cagcgtatct tccttagaca ggtgataaga cataaacggc atatctgtca caataaaggt 1888141 attcggcgca ccccttttaa cggcttttgt atgatggatc atgtccgcaa ctgtcacacc 1888201 gacagttgaa tcaaggccga ggacgaccat tccaagtgaa tcaccgacta aaatcatgtc 1888261 aactcccgct tgttcagcaa gtttagctgc cggataatca taagcggtca gcatgacaat 1888321 cggttcttca gactccttca tttttagaaa atccagtttt gttttcatgt tttctcctcc 1888381 tcatgtttag aggagatgat ctgccgtttt cttctgcaag ccaaaaaacc ttccgttaca 1888441 acgagaagga ttcttcactt tctaaagttc ggcgagtttc atccctctgt cccagtcctt 1888501 ttttggatca aggcagactg ctgcaatgtc tatctatttt aataataggt gcagttcgca 1888561 ggcgatactg cccaatggaa gtataccaaa atcaacgggc ttgtaccaac acattagccc 1888621 aattcgatat cggcagaata gattttttta atgccttcgt tcgtttctaa aagcagaacg 1888681 ccttcatcat ctatacctaa cgccttaccg taaaaggttc cgtttaacgt tctggctctc 1888741 atattagtgc caataccgag cgcatagctt tcccataaaa gcttaatcgg cgtaaatccg 1888801 tgcgtcatat aatcccggta ccgtttctca aagcatagta aaatatgctg gatgacgccg 1888861 gcccgatcaa ttttttcccc agcagcttgg ctgaggcttg tcgcgatgtc cttcaattca 1888921 tctggaaaat cattaggctg ctggttaacg ttaatgccga tcccaatgat cactgaacgt 1888981 acgcggtctt cttcagcctg catttccgtt aggataccga ctgttttttt tccgttaatc 1889041 aaaatatcat ttggccattt aatatccgtt tggatgcctg ctgcctcttc tattccctgc 1889101 acaacagcta ctgcagcaag cagagtcagc tgcggtgttt tttggagcgg aatgtcaggc 1889161 cgcaaaatca ggctcatcca aacaccgttt ccttcttgag aatgccatac cctagacatt 1889221 cggccccttc cggctgtttg tttgtcagcc accacaaggg tgccttccgg tgcgttatta 1889281 ttcgcgagct catgagccgt tttttgcgtg cttgaaagaa cgtcatggta aataagatgc 1889341 tggcccatca cttccgtttt taatccaaaa cgaatttcgc tttcactgag ttttccgggt 1889401 tttttgatga gccgatatcc ttttcttcta acggcttcta cttcataacc ctctttccga 1889461 agctcttcaa tatgcttcca cacagcagtt cttgaacagc cgagagcatc actgattttt 1889521 tggccggaaa taaattcatt gccggcctga gaaaataatt caataaggtc ttttcttaat 1889581 gttgaccgca tgtcttcagc cactcctcta tgtgtttctt ttgattggag agcttccctg 1889641 tcacaacagc ctgctcgatc cactgtaatt cttctgacac ccattttccg gccggccggt 1889701 ttcgaagcgc aagcaagtcc ttacccgtga tatcaagatc cttaaggctt ttgatcggca 1889761 ggttttgata agcgtactga atgtccttca gtttcttttc atccagtttt tcgttttgcc 1889821 gaagctgcga tattttggcc gctgagagca gtgctttttt cccagctctg tacattgtca 1889881 ttgcgtcaag gctctggcca aacgtatcgg caatgtgaat ggcttccttg atcacttttc 1889941 ccgggagctt ccaggctttc aggaaaaggg gcgcgtcttt caaaactatg ccaaggttaa 1890001 ttaaaagagc agcccaaagc tcctcacggg atgttaaaga gaagaatgga aactcactcg 1890061 ttgaaatcag gttttctcgt ttatgataaa aaccaggaag ctcttcatac aatctcgttt 1890121 gaatgagtgt ttgaagcgcc tggcgagaag ctcttccctg cagcaatttc tcaaactcta 1890181 tagtttttcg ttcgactgaa acatgggaga ggagtgattt ttctttcgca atggcttctt 1890241 ctgtttccgg tgaaagcgta aagccaagct ggctcataaa gcgtacggct ctcagcatac 1890301 gaagcgcatc ctcttgaaat ctatcctcag gctttccaac ggttcgaatc actttctgat 1890361 caatatcttt cttgccgcca aaataatcaa gcaccttccc gtccgctgtc atggccatcg 1890421 cattgatcgt taaatctctg cgttttagat cctcttctaa tgatgagata aattgcactt 1890481 ctgacggtct tctgaaatca acataatcag attcagtccg gaatgtcgtg acttcatagg 1890541 tttcatcctc ccagagcaca ataatggtcc cgtgctcttt gcctacatca acagtccgct 1890601 gaaacagccg ttctacttga tcaggtgccg catctgtcgc gatatcgaca tctccgatcg 1890661 ttcgtttcat atagctgtca cgaactgcgc ccccgacaaa ataagcctga tggcccgctt 1890721 cgattaagat gcggagcacg ggaagtgctt tgataaaaac tttttccatg tgatcactcc 1890781 ggttctgcta aatcggcata aatctgttca tactggctga caattttttt agaagaaaat 1890841 tcattttcaa gcatctctat tgccgccttt gtaaaacgat tgcttagctg ttcatcttct 1890901 aaaatgctca tcgcgcgggc tgttgcggcc gtaacatcac cgacatccac caaaaatccg 1890961 ctcacattgt tttttataac ctcagggata ccgccaatgt ttgttccaat acaaggcact 1891021 ccgcaagcca tcgcttcaag caggacaagg ccaaagcttt ctttttcaga tagcagcagc 1891081 ttcaaatcgc taatagaata aagatcttca acacggtctt gatttccaag cattaagact 1891141 tggtcttcca agccatattt tctgataagc tcgcaggctg tcgatttctc cggaccgtct 1891201 ccgactaaaa gcagcttcgc tttcgttttg ccagcgatat tgcggaacac acggatgaca 1891261 tcctgcacgc gtttaacttt tctgaagttg gacacatgga tgacgacttt ttcatctggt 1891321 aaaattccat gtttctcttt aattgccgct gtgtttttct tcagatacac gcgctcgtct 1891381 ataaagttat aaatcgtttc aatttttttc tccggtttaa ttaaatcgta tgtttcagcc 1891441 gcaagcgctg aggagacggc cgtcaccctg tctgatgact caatagcaaa acggatcaga 1891501 tcttttagag acggatcata acctaacacc gtgatatccg tgccatgcaa agtggtaaca 1891561 atgccgatat tgcgtttcag catttgtttt gcaagatagg cgcaaacggc atgcgggaga 1891621 gcatagtgag catggataat gtctaaattc tcccgttccg ccacctcagc gattttgctt 1891681 gccaatgtca aatcatacgg aggatactta aaaacagcat attgattaac ctcaacttca 1891741 tgaaaatgaa tattgggatg atatgtattc agtctaaacg gaatgcttga tgtgatgaaa 1891801 tggatttcat gtcccttttc agcaagctgc ttccccagtt ctgtcgcaat gatacctgag 1891861 cctccaacgc tcggatagca tgtgattcct atttttagtt ttctcattgt tcgcccccaa 1891921 gcacatcatg atcaagcatc agcatccgtt tggaaaagaa accttcggca tactccacgc 1891981 ccgcttcttt accgtaaagc ttttctctcg cttcaacgat ttcaatatac ccattcgtca 1892041 gaggagtaga aacggaatcc tttgacggga taaactggct tttgtaggcg ttgaggcttt 1892101 gtttctttgc ctctattgta tccgagatat caataacaaa atccggctga tgaaaaccat 1892161 ttatcatata atagtaaacc ttgctgactt tatgcgccgg aaggcttttt tcgtctttat 1892221 atttatggat tccggcggaa aagatcgctt cttccaccag tgcagccgca ttgccgtgat 1892281 ccggatggcg atccttttta tacggcataa aaaccgcttt tggccgacag attctgatga 1892341 cagtgacaat tgaccgaatt gcctgatcac tcattattag gccgcggtct ggaagcgtta 1892401 gctgaattct tttatctgcg cctaatatgc gggctgcttc agctgcttct tctttacgca 1892461 aactgaccgt accgttagaa gagagttccg cttctgtcaa atcgcatatc attacttttt 1892521 tttcctgttt gacaaacttc gctattgtgc cgcccattcc gatctcgaca tcatcactgt 1892581 gggcgccaaa agcaagaacg tcagcattat acattcggct cttctccccg aagaaggtca 1892641 cggaattcga aaacaccttc atcaagtgtg cgcacaagaa tttccgcagt acccatattt 1892701 gtggcgagcg gaatggaata cacatcacat aaacggatta atgccgagac atccggttca 1892761 tgcggctgcg cggtcagcgg gtcgcgcaaa aaaatgacaa gatcgagtgc attggcagcg 1892821 atcagtgcac cgatttgctg gtctccccct aaagggccgg attgaaaacg ttcaatttga 1892881 agacctgtcg cctcatgaat tttcaaccct gtggttccgg ttgcgtatag atcatgattc 1892941 tttaaaatat cccgataggc agtcgtaaat tgaaccatat cctgtttttt cttgtcatgc 1893001 gcgatcaaag caattttcat tgtttatccc cccgtctaat caatgatatt ttctaaacca 1893061 tacacaagct gatcaatctt catgacttgt tcgactgaca gtttaacgcc tgacatgaaa 1893121 gaagcacggt tataagaatc atggcgtatc tgaagcgttt ggccatccat gccgaacatg 1893181 acctcctgat gcgcgatcag tcccggaaga cggacgctgt gcaagcgaat accgttttgc 1893241 tccgctcctc ttgctcctgg gagaatttct ttttcatccg gatgtccttg ctgcttttct 1893301 ttacggactt ctgaaatcat ttccgctgtt ttaagcgcag ttccgcttgg tgcgtcaagc 1893361 ttctggtcat gatgaagctc aataatctca acatcctcaa aatagttggc agccattttt 1893421 gaaaatttca tcatcagtat cgcaccgagc gcaaaatttg gcgcgatgat ggctccgatc 1893481 cctttttctt ctgttaaaga tgtgagctct tttaaatcag cttctgagaa accggttgtt 1893541 ccgacaactg gacggactcc gtgctctaat gcaatttttg tatgtacttt tccgatttcg 1893601 ggcgttgtta aatcaatcaa gacatccggt tgtgtttctg taaaacaggc atggatatct 1893661 gtgtaaatga aagcatctga ctcaacaggc atcacatcag ataatttttg ctgatcgtat 1893721 gtatggtcta tggcccctac aaggtcaaaa tgtggtgttc gttctgccaa tttaacagct 1893781 tcctgcccca ttcttccacg cggtcccgca atgactaatt taattgtttc gtttgacatc 1893841 ttgatctcct ctactttcct tcttcttttc tggtccagcg atctttatct cttgtattaa 1893901 atttatgcat gactcggtcg tgagcttcct ctaaagagat atcaagagag ttggctaaac 1893961 aaaccaatac aaatagcaca tcgcctattt cctcttccat gcttttatca tcttcagtcg 1894021 ctttttttgg tttttctcca taacggtgat tcacttctct ggcaagctcg cccagttctt 1894081 cagtcagcct cgccatcatg gccagcgggc taaaatatcc ttctttaaat tggcctatgt 1894141 aacggtctac ttcagcctgt atgtctttca ttgttttatc actcactgaa cgaaacctcc 1894201 tatcatcctc ttacatgtta gctaattcag atacgtttga caaatgttta agcacgtttg 1894261 ctgttttctt tttcatccac tataatataa acgctatcta atggaaggaa aaggggtttt 1894321 gtgtgatgct tggagaaatt agattaaaaa acatattttt tattttaatc ggagcggcaa 1894381 ttttttcatt tggcttggtt catttcaata tgcagaacaa tctggctgag ggcggtttta 1894441 caggtattac acttttgctt tatgcccttt tccacatcag cccctctata tcgaacctgg 1894501 tgttgaacat tccgattttt tttattggct ggcgtttgct cggcaggaca atgtttgttt 1894561 atacccttgt cggcactgta gccttgtctt tgttcctcag catctttcag cgatatgaaa 1894621 tccatatgcc ccttcagcac gacttagcgc tcgccgcttt atttgccggc gtattcatcg 1894681 gagccggact gggtattatt tttaagttcg gcggtacgac aggcggtgtt gatatcatcg 1894741 cacgtttagt gaataagtat tttgggattc cgatgggcag aacgatgttt gctttcgatg 1894801 cctgcgtcat cattttgtct ttgcttactt atctctccta taaagaagcg atgtatacgc 1894861 tggtagctgt atttgtagcg gcaagattaa tcgattttat tcaggaaggc ggatacgctg 1894921 ctaaaggcgc tacgatcatc tcttcgaaaa acgacctgat tcagaaaaag attcttgaag 1894981 aaatggaacg gggcgtcacc attttgaaag gacaaggttc ctacacaaaa gaggatatag 1895041 atgtacttta ttgtgtggtg ccgaaaaatg aattggtgat gctgaaaagc gtgattaact 1895101 ccattgatcc ccatgccttt gtagcggtaa gcgatgttca cgatgtgctc ggagaaggat 1895161 ttacgcttga tgaaaataaa aatccgcttc cgcgctgaca tgtaatagaa aaaaggcggc 1895221 tgaccgccgc ccctcatcct tatttagggt agtccctttt tttcagcttg tttttttccg 1895281 ccttgtactt tctgtaaccg acataggtaa gagcagtaat gatgatactg ccggttgtaa 1895341 tgatcaccca gagtaaagac ggatcggcat catcctcctc caccctgtca aacacatttt 1895401 tcaggtcatg ctgaagaagg gaaagccgtt caagcttcgt gctctctgtc atttgctgaa 1895461 attcctcttg ctcaataaca tctatatgtt ttccgactgt ttcaagctga tcctctgata 1895521 catcgattgt aagactgggg taaatcaagt catataaact gataaattca ttccattttt 1895581 catgaaagct tgtgcttcca ttcttttgga catctcgctt cagttcagta aaagcttcca 1895641 taatcggttt ttccagtgag ccccaaagcg ggtcagaccg attgtcaacc gcatccatca 1895701 gcattctgaa ctgcgcggct gctctgagtt tttgtgtgtc tgatgtatca gcttgcttta 1895761 aactccgaac catatcatta tagcccaatg tgatttgacg aatttgggct cccgttagca 1895821 tggggtcttg ctgttttttc tcagcggatt ttaatgtttt ttcaaaatac tccaagactt 1895881 gaagcgcctc ttcatatttc gcctgtcggg tcatttgaaa gactgtatcg gataaatcat 1895941 tcaattcctc gaggcttccc cgctctgcag ccttggcatt tccattataa aaaataagtg 1896001 caatcaacaa acagatcgtc agctttcgtt tcatgcaggt ccctcccact ctctctcctt 1896061 acagaatatg aagaaaggga caaggataga ccaacattgt ctttacatca gctcaagctt 1896121 cgtttgcttt tttgagacca caagaaagta agcaagcgcg attgaaaaga tacttagcca 1896181 aaatgttccg tatcctattt cagtcatata atcagaaagc atagagtatt gcggcatcat 1896241 atcaaacaag tagtcaatga catcgttatg cagtgtccag actgcagcaa ttgcaagatg 1896301 ccaaaatgaa aaacgaaaat acggactgta taatacgcct tgaactgcca ttgcaaaatg 1896361 cgaagcaatt agcatgtagc cctcccacgg caagtcacca gttactgcaa gcacaagaaa 1896421 attcatagcc accgcccata ggccatactt tacgagggta actagcgcaa gcgcctctaa 1896481 aagcggagca ttccgtttca tgagaaaggc aagcagcaca aacagaaaga aaaacgttgc 1896541 tgtcggactg tccggaacaa aaatcaggaa acgggccggt gtctccaaaa gctgcggcaa 1896601 gtaccaatag tagccgtaaa ccgttcccag aaaattaatg gctaagacaa gaataagcat 1896661 cggccgctgc cctaatacat attgaaacca tttcacatcg aatcaactct cagtctgtaa 1896721 aaataatatg tccatataaa aaagctgacg ccgggtcagc ttttgataat aaaagtatat 1896781 ccttccattt gacaattcac aatacgttat tttgcggttg tttcagaaat aaattttgca 1896841 agttcttcga gctgcttatc atttcctttg aacacacccg ccggcatttt gcctttccct 1896901 tctacagcga tttttttgat ttcatccggt ttcagcccgc tgtcaaccaa tgaaggcccg 1896961 gccgctcctc cctgaaggtt atccccatgg caagaaatac agccctgttc cttaaaaacc 1897021 ttatatcctt ctgcattggt gtcaatgtcg gcttcttttg taattttccc ctgttcttct 1897081 gccttggccc agtcatgagt agcaactgac tgccacgtca aaaatacagc agcggaaatg 1897141 gccagaagca tcataccgac agcgaccgga cgcttccacg gccttctttc tgtccctctg 1897201 tctaggaatg gagccaaaag cagggcccca aaagcgagac ctggcataat catggcgccg 1897261 accactgtaa agcttccggc ggcgtattca tacttcaaca gctggtataa gaaaagaaaa 1897321 taccaatccg gcagcggaat ataaccagta tcagtcgggt ccgccatccg ctctaaaggc 1897381 ggctgatgca caatcgtcaa aacgagaaaa ccgatgagaa agacagctcc aaccatccat 1897441 tcctttaaca agaaatttgg ccagaaagcc tctgttttac ccggatactc cgaataatcc 1897501 ttcggtatat tcggcttttt ttcagccggt atccttgagt cgcctacaaa tttcatccct 1897561 ttgccccggt gcatgtcatc ccctcccttt tattcgcaga tcaagagttt aaagcggtcc 1897621 tgaaatcccc tgcttccgga tcataataaa atgtgcagcc atcagcccga acaatgcggc 1897681 aggaagaaaa aatacatgga tcgcaaaaaa cctagtcagc gtttgggcgc ctacaatatc 1897741 cggatgccct gcaaggagcg ttttaacttg cgttccgatc aaaggcgtgg cttcggcgat 1897801 ctgcagtccg acttttgttg caaacagagc cttcatatcc caaggaagca agtagcctgt 1897861 aaagccaaga ccgagcataa caaaaaagat cagcacaccg acaatccagt tcagctcgcg 1897921 cggtttttta tacgcgcctt ggaaaaagac cctcagcgta tgtaaaaaca tcatcacaat 1897981 gaccaggctc gcaccccagt ggtgcatccc cctgacaatc tggccgaatg ccacttcatt 1898041 ttgcaaataa tataccgatt cccaggcatt tttgatatca ggcacataat acatcgttaa 1898101 aaacattcca gataatactt ggataacggt tacaaaaaac gtcagtcccc caaagcaata 1898161 cacaaacgca gagaaatgat gggcgggatt cacatgttcc ggtacttcgt gatcggcaat 1898221 atccctccac atcggtgtaa tatcaagccg ctcgtctacc cagtcataaa ttttgttcag 1898281 catgtcaccc ttccccctta ggctttgctt ttccaagata caggaagccg tcttttactt 1898341 cttgctcata atgatcaaga ggcgcaagcg gcggcgtgcc agggacattg gtgccgtcct 1898401 tttcatagag tccgtaatgg catggacaaa agaatttatt cgggttttta ggatcactat 1898461 tccagttcac cgtacaccct aaatgcttac aaattggcga aagtgctaca atttcatccc 1898521 cgtttttgaa gacccaggct gatcttgact cttctgactc ataccaggca tcgacttgat 1898581 taattttaaa atcaaagcgc tgcggctctt ttgtcaactc atcaacgctg acaacctgaa 1898641 ccatatcctg cttccctgtc gattttaata ccgggtcgag tgcgaagcga accataggca 1898701 tgagcatact agccgccata aaacctccta cgcctgtgag cgtataattc aaaaattgac 1898761 gtctggatat atcatgtttt ccgcccatct cttctccccc ctctaagtca cccctgcaaa 1898821 ctgactaaaa tagaaaatat tgcaataact ctagacaccc tcataatata tgaatctctc 1898881 agcaaggtca atatagccaa aatattgttt ataaggaaat gtaagtgttt ttataaagtg 1898941 ctccataact gtaacaaaac gttcaaaatt tcagcagtgc gttcatccaa tatttttctt 1899001 tttaaagagt catttaaatg ctctaatgga acagacgatg taacaatcat tttgcctaac 1899061 gcatcctcag ctctccaact ttcgtcagat gtgagcagga caacatgcgg aaattccgtt 1899121 atcagctctt cccgcaaatc cttaagccct tgaacggtta tttcatttct atcaacatat 1899181 gtataaggcg gaagtaaata tacccgtccc tttaactgcc tttcaagttc ttctgagaga 1899241 agctgcgtaa actcgccttt ctccgccgcc attttaaaat ggttattaac ccttatgtta 1899301 attaatggta tgacagcggt atcaatgtaa tccttagctt gtaaatagtc cttggcatca 1899361 gtgattctcc acctcatcgt tctccccctt tacggcaaca agccttgcaa ttcactgcaa 1899421 ggctggtcat attatgtgag ctgatttaat tggcgcgata attgttcaaa tgcctcttta 1899481 tcatgacgat ctaacgcgtc gtcaatgtct tttaataatt tttctctttg gaatgtggaa 1899541 atagcgtgct ctaaaatctg ttccgccaat ccctgatctt ttttattctc aaaaaggttt 1899601 ttcggaatat gcgggttgga ctccagcacc gccgcatatt caggtgagct gtaagccgaa 1899661 cggaaattaa gctggataaa caaatcctgc tgtttattta atctaatatc atgaaaagat 1899721 ttttccgcgt cggtagtcat gacattctct ttatagaacc ggaacggaac ttcttcaaca 1899781 caatgtgttg acattataat gcctctcggg caaaattcag cctgctccac aaaatgaacc 1899841 ttctccatga gagaatcatg gctcattaag tagttcaaga tccaaacgca ctctcggcgc 1899901 tttaactgat aatggtttaa aaaccaacgg ataaaatctt ttttctcatt gacagaaaca 1899961 ggggtctgca tgtaattccc tcctctatcg ttcgtataat ctatatactt atatgttcca 1900021 catgaatggt taatattcct gcttatctag aaaattcatc ctcgattcgc aaaatcgttt 1900081 cttcaagctc ttcattggct ccgtccattt caagaacctt tttcaaaagc ggcagcgctt 1900141 ctttttgaag accttcttct aataggaagc ttgcgtattc atataagaaa tctctatcct 1900201 cccggtaatg aagataggca gcctcaaagg attgttttgc ttcctcgtat tgctctaatt 1900261 cagtatatgc gcttgcaaga taccaattgt atttaggatc ttcttcaccg tagcttcgaa 1900321 cctcttgaat aagatcaatg atctgatcat aatcctcttc tttgtgatac acggcaagaa 1900381 gtgtatgaag cgcctcgaca aagcccggat caagcgcaag cgcctcctga agcagcttct 1900441 tcccctcttc tgacttcccg attttcaagg ccattttggc ggcataaagg aaaagttctt 1900501 tgttatattc atcatatctg atcccctctt ttgccgtttt taatgcctct tcatacattc 1900561 cttcagcttc atagcttttc gagagcggca tataaagtga agtataagat ggatcaagct 1900621 cctttaaatc agacagctgc ttaatagctg ttttcacaag ccccgcctgt aaggctgtaa 1900681 aaccatagcc gaaaatcgta ttaggatcag gattctcatc gacagctttc tcataccatg 1900741 gaatggcatc ctcaaattca cctgaggcac ttaacgattc tgccagtctt tgatggacat 1900801 taacgccccc gatctcactc tgctcctcag ccgttgtttt aaaatattga accgcttttg 1900861 cataggctcc ctgagcaaag taaagttctc ccagtgcaaa atcaataaca ggttcattgt 1900921 ccagaatgga ctttgcctgg aaaagctttt gttcactgac ttcgaataac ccctgcatct 1900981 gataaagatc cgccataagc agcaaacttt ccggatatga tggatctgtt tccggaatag 1901041 tctccagcac agcgagggct ttttcttctt cgtcaatatc tattaaaagt tcagcgtaga 1901101 aattcgtcag ttctgtttca tttggatata aatcatgtag atcactaatc agtgaaatgg 1901161 ctttttctac atcgccccac tcgtaataaa gctgggctgc aatggcttta tcttcatcat 1901221 gcagctgttt ttcagccttc gagagcgtgt tgaggccttt ttctgtttca cctgcttcaa 1901281 ctaattttat ggcttcttga atcaatgtat tcaaatcgga ccggtccttt cttttcctat 1901341 acaacatcaa ccatacaaaa aaagctttat ttgttcgggt taatcttatc ataattcaga 1901401 cgaatgcccc cggcaaataa gatgcttctg tacggaaggg aattattgag tcttattagt 1901461 ttaccaaaag atcttgagat agaaaatgaa aaaaggaaga tcgccctctg tacagtaaag 1901521 cagctctttg acctgccggc ttgtaagtaa agcacatccc cccttttcgt ttttctatcc 1901581 gttctataag acaagctatg ttttttcgcc tcgaattatg atctgcataa aaaatcctga 1901641 agtaaaactt caggattttt tcgaaagctt atttaaatgc tcgaagaagg ttggataaga 1901701 aacgtgaatg gcatccgtgt gctcgatttc aatcggctcc tccgttatac aggaagcaat 1901761 accaagcatc attccgattc gatgatctcc gtggctggac actgcagcgc cgcctttcaa 1901821 cgtttgtttg ccataaacct tcattccatc tgctgtcggt tcaatttcag cacccagctt 1901881 gcgaagctca gaaacaacag tatcaatacg gtttgtttct ttcactttta gctctgccgc 1901941 gtccttaata acggtggttc cttccgcctg agtcgcaaga agcgcgatga tagggatctc 1902001 atcaattaaa cgcggaatga tatctcctcc gatttcaact gcctttagag atgacgtttc 1902061 tataatcaaa tctccataag gctctgcacc gctatcagca gatggtttga tttcaagttt 1902121 tgcccccatg ttttgaagga catcaataat acctgtccga gtcggattta aacctacgtt 1902181 tttcaataca attctgctgt ttggaaccat cgcgccagca gcaaggaaaa acgcggctga 1902241 agaaatgtct ccaggaacaa aaatatcagc agctgtcagt ttctggccac cagcaatgga 1902301 aacactcgtt tgatcttcag aaagcttaac gccaaaagca gaaagcatcc gctcagtgtg 1902361 gtcccgagat ttatggggct ctgttacagt tgttgtgccc tcagcctgta atccggccag 1902421 caaaacagca gatttaattt gcgcgcttgc aacaggtgat acataatcaa ttccttttaa 1902481 tgaagcgccg ctcactgaca gcggtgtaaa ctctccgccg gctctgccgt cgattttagc 1902541 ccccattttt ttcaaaggct cagtcacacg cttcattggg cgtttcgcaa tgctctcatc 1902601 tccggctacc gcgctgtaaa aaggacggcc cgccaatatt ccgagcatca ggcgaatcgt 1902661 tgtacctgaa tttccgacat ctaaaaggct ttctggctct ttcagggcat cgattccttt 1902721 tccgtgaatc acgacatcgc tgctgctttg ctcaatgtga acacccattt ttctaaagca 1902781 atcgatcgtg ctcagacaat ctgctcccgg cagaaagttt ttaactgttg ttgtgcctgc 1902841 cgctagcgcg ccaaacataa cagagcggtg agaaatggat ttatcaccgg gaatatgtat 1902901 ttctccatgt aaggtctgca ccttatctcg tttcattttt tccacctcaa tcagcataaa 1902961 aagtttcata ttccgcccgg gcttcaatgc attgttctgc ccttttgcgg tcgtcatcag 1903021 actgaaaact gatccttaaa atcccgttaa tatcctctcg tgtttcgata atgcggatat 1903081 tcgtgatact gatgcgctcc gcagctaaga tcgctgttat ctcggatatt acacccggat 1903141 gatcgggtac atccacatat aaatcataaa atgcaggtat cgctcccttc tgccgaagcg 1903201 gcagcccgtc gcgataatcc ttggctgttt taaaataacg aaatagattt tccgcatctt 1903261 cttgttctac atatgtacgg atcttgtcaa tttcacgaat ccactcatca aaacggtcta 1903321 agattttatc tttattatgt aataaaatat cccgccacat tgccgggctg cttgatgcaa 1903381 tccttgtaat atctctgaac ccgccggcag caaaacgctt aacaagcgga tacaggtttt 1903441 ccgaatgatg ggtttggtga acaaggctag ctgctacaat atgcggaaaa tgactgatta 1903501 cgcttgtaac gccatcatgc tcctctggcg acatttccac aaaatgggca ttcgtcccct 1903561 tcagcaggtt ttttaactgt tccacagctt gtttgtccgt tttctggcct ggcgttaaaa 1903621 tataaaatgc attttcaaac aggaactcct tcgcagcggc cactcctgat ttatgtgaac 1903681 ccgccatcgg atgccctccg acaaattgat agcggctagg cagcacttga tcagcgtaat 1903741 caaccacttt ttgctttgtg cttcctacat ccgtaatcaa aagctcatgt tcaattcctg 1903801 aatgagccag ctcttcaagc ataaccagtg tttgttcaac aggtgtcgca atgattactg 1903861 tagctgcctc tttcacaccg ctaataaacg aatcagcacg atcgtctatc acgcctaatt 1903921 ttaatgccgc taccgcctgt tcatcagaga tgtcgattcc gataatccgt ttgccgggat 1903981 gatttttttt gatggctagg gcaatcgaac cgcctatcaa tccgagaccg gcgagcaata 1904041 ttgtatcttt catttgattc atacgtcatc acctggttta tagactaaag aggtgatatt 1904101 tgatcacctc ttataaaatt tcagctaaaa tggcaagtat ttcttcattt tgctcttttg 1904161 ttccgatcgt aatccggagt gatgtcggga aacctaatgc gtttcctgac cggacgatat 1904221 agcctttttc cagcagagcc tgaaacagtt catcagcagg acgtttaaag tcaattaaca 1904281 caaaatttgt ctgtgaaggg tagcacttta aaccatgagt tttcgcaaaa tcataatact 1904341 gctgaaggcc tgcattattt tgctcgacac aggaagcaat aaacgcttga tcatcaagtg 1904401 ctgcaatcgc cgcagcctgg cccagacggc tggtattaaa cggctctctc gccggctcaa 1904461 tctggcgaat caggttctcg tcagcaattc cgtatccgac tctgagcgct gccagaccgt 1904521 atgcctttga aaatgtgcgc aaaatcatca aattggaata cttgcttaag agcggcacgg 1904581 tttccgggta atcctctgct gttacatatt cataatatgc ttcgtcaaga acgacaagga 1904641 cacgagaagg aacgcgctcc agaaatgcga gtaattctcc ttcagatgta taagtgccag 1904701 tcggattatt cgggctgcat atccaaacga cttgtgtctg ttcgtcgatg gcttctaaca 1904761 tggcgtctaa atcatgtgag ccgtcgggac gaagtgcaat ttcacgtact tcagcacctt 1904821 caataaccgc attatgttta tattgcggaa aagtgggggc agcagtaacc gtgtttgttt 1904881 tatcgtttaa aaatgcccgg cagatgatct gtatgatttc atcagaaccg ttgccgaaaa 1904941 taagtgatgt ttcgctgaca ttgaggtgct tactgagcct tgtccgcaaa gcggcgctat 1905001 acccgtccgg gtaaagggct agctgttgaa tctcatgatg aagcgcctct tttgcagcct 1905061 ctgaacagcc gtaaggattc tcgtttgaag caagcttcac aactttatcc aagccatatt 1905121 ctgatttcac tgcttcaatc ggctttccag gctgataagg cttcagctgt tttaaatgtt 1905181 ctttgatacg caaatcagtc acctcatttt aaactgtaca agccgctaaa cgccattgca 1905241 taatcctcaa actcctgcag cgcctgattt ctcgtttcag cgctgatgag ccggtccttt 1905301 aattcttcta tttttctgac gagcgcactt cccactacga caccgtcact aatttcattc 1905361 atctttatga cctgttcacg gtttgatata ccgaacccta cagcaaccgg aacagtgctg 1905421 agattcttca cagtacgaat gaacgggtac acggatgaat tgaactcatt gcggacaccg 1905481 gtcacaccca gagaagatac acagtagacg aacccctcgg cttgttcaat aatggttttc 1905541 aaacggcttt cgcttgtcgg cgcaactaaa gaaatatacg tcacctcatg gcttttacat 1905601 tcctcttgaa ggctgttgct ttcttctaat ggcagatccg gaacaagcag accgtcaata 1905661 tgattttccc gcagtaaagc gaaaaagtat tctttgttca attgtaacac aggattataa 1905721 tacgtaaaga ggataatcgg aatattcact ccgttttttt tcatttctcc gcctaattcg 1905781 attgccttta cgatattcat tccttgatca agcgcccgct ttgaagcccg ctggatcacc 1905841 ggaccgtctg caagcgggtc agagtatgca acaccaagct ccaatgctgt ggcgcctgct 1905901 ttttggagtg acttcgccag ttcaatcgaa acctcaggaa ctggatcgcc cgccgtaata 1905961 aacgggataa acaatttttc tgatggttga agatccaatt taaacatggg ctttcacctc 1906021 ttcttccaat acattcatta atgtgttgac atccttgtct ccccggcctg ataaacagac 1906081 gagaatgagt tgaccgcgat ccattccttt ggcgagtttg aatgctttcg ctaacgcatg 1906141 ggcagattcg attgccggca aaatcccctc tttttctgac aaaagcttta atgcatccac 1906201 cgcttcttca tcggttatac tgtcataagt gacacggccg cttttatgca aatatgcatg 1906261 ctccggaccg attccaggat agtcgagacc ggctgaaata gagtagggct caataatttg 1906321 cccgaactca tcctgaatga gataagtcaa tgaaccgtga ataaccccta cggttccttt 1906381 cgaaatagtg gcggcatgaa gaggtgtatc aattcctttt cctgctgctt cagcgccgat 1906441 cagttcaaca tcttcattta aaaatgcctg aaacataccc atcgcattgc ttcctccgcc 1906501 tacacatgcc actactttat caggcatagt gccttcaata cgtttcaact gatccttcgc 1906561 ttcctctccg atcatttttt gaaattcacg gaccacttgc ggataaggat gcgggccgac 1906621 aactgatcca atcatataaa agtgatcctc acaatgctga acccagtacc ggatcgcctc 1906681 atttgtggca tccttcaatg ttccgtttcc gcttgttaca ggcactacct ccgctccaag 1906741 aagcttcatg cggaaaacgt tcagagactg gcgggcaaca tcctcttcac ccataaacac 1906801 agtacaggaa aagccgaatt tggctgcaac tgttgcagcg gcaacaccat gctggccggc 1906861 accggtttca gcaatgattt tcgttttgcc cattttttta gcaagcagcg cttgacctag 1906921 cgcattattg attttatgag aacctgtatg gtttaaatct tctcgtttca aatagatttt 1906981 cgcgccgcct aagtattcag tgactcgatc agcgtatgtt aatgcagtcg ggcgtccgga 1907041 atagtccttt aacagcttat aatactcttc acgaaaagcg ggatcatcct tgatttgttt 1907101 aaatgctgtt tgtatttcat ctaacggctg catgagtgtt tccggaacaa actttccgcc 1907161 aaaatcaccg tatctgccta tttcattcgg atatggatac atatcggttc atcctttctt 1907221 ctaaaagcct catcagattc tgatcttttt gtccgttttt ttcaattccg ctggcaaggt 1907281 caattccttc tggctgccat ttcaataggc gtgtgatgct atccggattc acgccgccag 1907341 cgataaagca gcgtttacca atagccgcct gctgatattc cggcacacat tcccaagaaa 1907401 atgcaacacc agttccgcct ctagaccctt ttacagatga atcaatcaca aagccgtcaa 1907461 cattatcttt aaagcgggct atttcttgag ttgtgttatc ttgatggtga agcgccttcc 1907521 atatttcaca gcctgtcagc ttgcgaagag cagcagcatc cgccggtttt tcatcaccgt 1907581 gaagctgaat gacgtcgagc ttcaagctct tggcaatacg tgacatcgtc tctattgatt 1907641 cattaacaaa aacacctgca acctgttttt cgacacgaac ttggttcagc cattttttca 1907701 catcttccgg agatactttt cgtttgcttt cagcaaaaat aaatcctagg taatcagcct 1907761 gtgattccgc cgcaagctgc aaatccttta gtgaccgaat accgcaatat tttaatgccg 1907821 gtttcttcac aacctcactc cctaaacaaa gcatggattg ctttacgctg agaagtttgt 1907881 ctcatcaatg attcaccgat aagtacagct cgtgctccat gttctttgac aaatgttaaa 1907941 tgttctaaag aaccgattcc gctttcgctg acaagcagtg attctttcgg agcaagagat 1908001 gcgatttgtt ctgtctgcat gatagaggtt tcaaaagttt ttaggtttcg gttgtttatg 1908061 ccgagaatat caggcgtgaa tactttcaat atttgttcta gcgttgttgc atcatgaacc 1908121 tccactaaca cgtccatctc cttttcacct gcttcaagat ataattcatg aaggtgtaag 1908181 ggatcaagca cttcgccgat taacaatatg gcatccgctc cgattcttct tgattcctcc 1908241 acttgaagag aatcaataat aaaatctttt ctgagtacag gtatcgaaac agcgcgcttt 1908301 acgtctgata aatagctgtt ttccccttga aaaaacgggg tgtctgttaa aacggaaagc 1908361 gcatctgctt tcgcagtttc atagtctttt gcaatccgca caggtacaaa attctcttta 1908421 ataagccctt ttgacggcga cgctttcttc acttcagcaa tcaacccgat aaaccgattc 1908481 aggcttgcca gcgcctcttt aaatgaacgt ttttcgaaag gctgctctac cggcagaacc 1908541 agtgttttca cttcttcttt cttttgtttg atgatttttt caagcataga tctcttcctc 1908601 tttctgcttt agtcgttcaa gctgcgcggc agcgcctccg cttgtaatcg tctctaacgc 1908661 cagctccgtt ccttccttca gtgaggcggt aattcccgcc gtgtaaatcg cagcacccgc 1908721 attaaaagcc gtaatagata aagcggaact gctgctttta ttttcaaaaa tattctgaat 1908781 gagataagcg ctctctttcg gagactgcac ctgtaaatct tcaagtctgc catttgtgaa 1908841 accgaaatct tcgggtgaaa cggtatactc ccggcgctct ccgtccttta attcaatcac 1908901 gtcggtcggt gctgtaattg aaagctcatc taaaccgtca cggcttgata caaacataac 1908961 gtgcttcggc tgaaacgtct ccagtgcgct tgccatcagt ccagcttttt caacagaata 1909021 gaccccaatc acctgacgct tcgcctgtaa aggattgctg agcggcccaa gcagattaaa 1909081 taccgttctg aaacctagct cttttctagt acctgctaca tgtttcatag acgaatggta 1909141 aagcggcgca aaaagaaatc ccatgttgtt tgtttcaatg ctgcttttga ccttttcggg 1909201 agtggtttga atagaaacct ctagctcctc taaaacatca gcgcttccgc ttttagaaga 1909261 gacagagcga ttgccatgct tagcgatttt cgcaccagct gccgaggcaa caattgccga 1909321 ggccgttgag atattaaaag tggaaatacc gtctccccct gttccgcatg tatcaacaat 1909381 atcaggaagt ccatcgactg taagagcgtg tgcccgcatt gccttcacaa aacccgcaag 1909441 ctcttctggc gtctcccccc gatgagcaag aattgacaat atccccccca tttcagaagg 1909501 agtcatttcc gctgccatca tcatattcat cagcgtttca gcctcaccgg cagtaagggt 1909561 ttttccgtca acgcacaatt gtagaaatct gttcatcagc tttatcctcc ttgctatgaa 1909621 acatgtcttc tgcaatatga atcgttttca gcagcgcacc ggctttatta cagctttctt 1909681 cgtattcggc ttccggaaca gaatcagcaa caatgccagc acctgcctgt atcgatgcaa 1909741 caccgttctt tacactcatc gtgcgaatcg taatacaaga gtcgatattc ccgtcaaacc 1909801 caatgtaggc aatacaccct ccgtatgtct ctctcggtgt tggctcgagt tcttgcaaaa 1909861 gctgcatggc acggattttg ggtgcgcctg ttaaagtccc cgccgggaaa gcagacatca 1909921 gtgcatcgac aggatgaacc ccttttttca atcggcctgt aaccaccgag ataatgtgca 1909981 tgacatgtga aaaggaaaca atttttgtga actccggcac agaaacagaa ccatactctg 1910041 ctactctgcc gatatcgttt cgggcaagat caacgagcat gtaatgctcc gctttttctt 1910101 tttcatcctt catgagctca accttcagtc tctcatcttc agctttgtct gcaccgcgtt 1910161 ttctcgtacc ggcaatcgga tggatttcta agtgcccgtc ttgaacgtgt attaaccgtt 1910221 ccggagagct gccgactatt tctctgtcta gcagtttcat ataatacata tacggcgaag 1910281 gattgacgat cctaagcact cggtataact caaaagcatc tgcttttatc ggcacctcaa 1910341 atttttgtga taaaacaccc tggaagatat cgcctgcttt tatatagctt ttgatttttt 1910401 ctacatcagc cataaaagcc gatttttcat aattagaaga tactgtctca aagctgggtg 1910461 tcttgtatga atcagcagaa agaaacagct cttttatgtt tttttggtcc atcatttttt 1910521 caatgagatt ttgaagctcc agatgatttt gatggaatac atccattttt tcgttttttg 1910581 tttcctctcc agtgagcctt gcatattgga taaagtggac gtttttggtt tcatgatcat 1910641 acgcaattaa tgtccggcaa acaaacagca tacacttttc catgtctgtt tctttggtat 1910701 gcgaaggaac agaaggctca atcagcggga tcatatcata gcttaagtac ccgacagctc 1910761 cgccgacaaa aggaatgcca agctcaggtg ttttgatttt gtatgtggta ttcatccagt 1910821 tcagcacttc ttttagttca tttcctgtgt aaagagattt gctgtcctga tcagcggccg 1910881 aaaaacggcc ctgctcttct ttaattgtga gaaatggatt caggccgata aacgaatatc 1910941 tggaccaagt ggatgtatcg tccttgcttt caagaagata cgtaatctcc ctgtcaagct 1911001 tctctatcat ttgaatgggt gtcagtgtat cgactgtgaa ggtctccaca atcggtatcg 1911061 tgtggtggga caagctgtcc tctaaaaatg cggaaatgtt tgattggaaa ttcattgctc 1911121 tcactcctta tggcaaggag aatgagaaga tggcatgaga ggataaaata ctatataaca 1911181 aataaaccca aaagaaagac ttcttttggg tagaataaac ataatgtctc agctcaacta 1911241 aactcattct ctgctaccct attctctaac tcaactcatt ctaattgctt tatacacact 1911301 cttgtgtatt tctaagctgt tcttatcgta ttacaattca gtattttttg tcaatgataa 1911361 atcgggcctc aatacgacaa ctttttctaa atatacatgt ctgatctgat cctgagggac 1911421 atctgtctgg accgtcatca tgactcttat gcactttttc agaccgcctg ttacgtccat 1911481 ttcctgcata catgttaccg gtacatactg ccatcctgaa agctcgcgaa cagcttttgc 1911541 cgggaaaaca gcgtgcaaat caggtgtagc cgacagaagc atttgaacaa catcttccgg 1911601 ttttgtatga ttttcttcta tgattttctc taacagctgt ttagtttttt gtaaaatttc 1911661 ttcttcagta tcccgttcaa ctgtagttgc tccgcgaatt ccgcgaatca tcatgatgtc 1911721 tcctccaatc gccatttgtt cagccagctc tcaagttcat ttctggaaaa tgtatgatca 1911781 gcaactttcc ctaattcgtt gagcacaata aactgaatct tcccgccacg ggttttctta 1911841 tcattcatca tacggttcaa gagaaccgaa gtttccgtct cttttctgat ttgacttgga 1911901 taacccaggc tttttagcca gctgaccaaa cgttttctgt ccatttcaca gcctacagtc 1911961 ttttcgctta tatataaagc aaactgcatt ccgagggcta cggcatcacc gtgagtgatc 1912021 tgcccatatc catattccgc ctcaacggca tggccgagcg tatgcccaaa gtttaagtaa 1912081 gctcttatcc cctcttcttt ttcatcctgc tgaacgacag acgctttaat tgaaatgcct 1912141 ttaaaaatca tgtcattcag ctgatcatta gtgatatcac gcagtgagtg gatattcagc 1912201 agctcctcca gaaacgctct gtcatagata aaagcgtgtt taatcacttc tgccattccg 1912261 gacctaagct ctttttcagg cagagaacgc aggaaatctg tatcatagag cacggctttc 1912321 ggctgataaa acgcaccgat tagatttttt ccaagcggat ggttcacggc tacttttcct 1912381 ccgactgcgc tgtcatgcgc caagagcgtc gtaggcattt ggatgaaatc aatgccgcgc 1912441 ataaaagtgg cagccacaaa accggcaaga tcccctacaa caccgccacc gaatgcgatg 1912501 atgcatgagg agcgatccat atgaaaacga atcgcttcac tctgcaattt tgtgtacatg 1912561 tccatggatt ttgcctgctc tccactcggt accgtcactt ttttcacagg ccatttttct 1912621 tgcagcaaat ggagcatttc atcaccatac aggcggtcca cttcttcatc cgtgacaaac 1912681 ataatccttg ttaaaggcct gtttaaagag gttaatagtt cgcaagcctt ttttctgata 1912741 ccttgtccga taaaaacagg atatgacgag gaagcagttt gaacatgcag tgtcttcatt 1912801 aaaattccct cgacagtttt ctcatattct ccacattttc tctaatgcgg tcaatttgat 1912861 ctaatccgaa ttgttcaacg actgcgttcg caatttccca agcgacagcc gcttcagcga 1912921 ctacacttgc cgcaggaaca gcacagctgt ctgaacgttc aatgctggca gaaaacggtt 1912981 ctttcgtttc aatatcgaca cttttcagcg gtttatacaa agtcggaatc ggcttcatga 1913041 ctccgcggac aacaatcggc atccctgtcg tcatgccgcc ttccagtccg ccaagtctgt 1913101 tagtagcacg ggtgtatcct ttttcctcgt cccaaatgat ctcgtcatgg acttcgcttc 1913161 catttcgccc tgctgcctca aatccgatgc cgaattccac acctttaaat gcgttaattg 1913221 acagaacagc ggcagcaagc ttgctatcca gcttgcggtc ataatggaca tagctgccca 1913281 cgcctaccgg cattccctcg acaatgactt ctactattcc gccgatggaa tctccgtttg 1913341 cctttgcttc atcaatggca gccatcattt ttttgcctgc ctcttcatcg tagcatctga 1913401 caggagactc ttccgttaca cgctgcaagt cttcaattga cgtatactct gttttttcag 1913461 ctttaacagc gccaatttgc aacacgtggc ccgccacctt aatgccaagc tcagaaagaa 1913521 tctttttagc tacagcccct gccgccactc tgacagttgt ttcccttgct gaagaacgct 1913581 caagcacatt tctcatatca cgatgattat atttaattgc accgtttaag tcagcgtgcc 1913641 caggtctcgg tctggaaatc tggcgcttca tttccttttc ttcatcttct gtaatcggag 1913701 cggcgcccat gatttttgtc caatgcttcc aatcgttatt ttcaactacg agagcaattg 1913761 gcgaaccgag tgtacgtgca tggcgcaccc cgctcataat tttggcctgg tctttttcga 1913821 tctgcatgcg gcggccgcgg ccgtgtcctt tttggcgtct ggcaagctca aaattgatat 1913881 cttcctccgt tatgtaaagc ccggcaggta caccctcaat aatggttgtc agttgggggc 1913941 cgtgtgattc tccggctgtt aaatatctca tgacttcttc tcccttcatc gcattaacgc 1914001 ttttaagtaa gactactata acatattttt cagcaaaaag tcagtctatc ttttttgata 1914061 aaagaatgta tcggctggga ctaggccaaa tttctcggga ttgaagattt gctcggtgct 1914121 gccgacaaaa agaactccat tcttcttcaa gctatgtgcc atttttaaat acagctcttc 1914181 cttcgcgctt tctgtaaaat aaataaatac attgcggcac acgattaagt caaagtcttg 1914241 ttcataacga tccgccagca aattgtgctt tttgaatgta atattctttt tgatttccgt 1914301 tttcacttca taacttctat ttgcgttttg cgtaaaataa cgatctttca cagatagcgg 1914361 cacttcctgt aaagaccgct cctgataaac gccttttttc gctttttcca atgctttttc 1914421 atcaatatcc gtcgctaaaa tctgatagcc cggaagacct ttttgctggt ccaaaagcat 1914481 ggcaagcgtg tatggctcct cccccgttga gcaggcggca ctccaaattt ttaaaggcct 1914541 agaggtcttg attaacggca gaattgcagt ctcaagaact tcccatcttt tataattacg 1914601 ataaaattct gaaacattga tcgtcattct gtccaatgtt tcatttaaga gagcttgatc 1914661 cttttccaat gccgcagcaa agtccttaaa gctttggaac ccctttttct cataaagtga 1914721 cgttagcctt ctcttcattt gtgcttcttt atatagtgtt aaatcgactc cggttaattg 1914781 tttccatttc gttgtaaata cgctgtatgt atccatctct actctcccag tctcgctgtc 1914841 tttttgtcct agtatagctt gttttatcag gaaattgtat tgtttcaata aaaaaatcag 1914901 cttttcagct gattttagat cgttgggaaa ggcagaggtc tgatgcacac tgccattcaa 1914961 ccctttattc actttaatgt aaacctttac aaaacagaac aaaaaccggc ggcgttatat 1915021 gttgccggct ctgttgctta ttttcacaat gattaataga tccagcctgc cataagctgc 1915081 tgatatgata ctaattcttc attcttaaag aaaatgttaa tctcgcgttc tgcactttcg 1915141 agagaatcag agccgtggat gatgtttttt ccgacaaaca tgccataatc cccacgaatc 1915201 gtaccaggta aagcttcttt agggtttgtt ttcccgatca gctgtctcgt cacttcaatg 1915261 acattttcgc cttcccacac cattgcgaat acaggtcctg aagtaataaa ctcaacgagc 1915321 tctccgaaga aaggcttacc ttgatgttcg gcgtagtgtt tctcagccat ttgttcagtc 1915381 actctcatta acttggcgcc agctaattgt aagcccttac gttcgaatct agataaaatg 1915441 tccccaatga gctgacgttg gacaccgtct ggtttcacca tgataaaagt cttttccatc 1915501 atattctcca ccccatcatt atgtatgtat aggctttcac actgcacacc gaaatcgtaa 1915561 catctttctg ataattaatc aatccggggc ggagaaattt cttaatatct acaaaaatta 1915621 aaattttctt ttaccgatat attttgcgat ggctgcaaga gacgagcgtg cgcgccctcg 1915681 aggaagcgtg tttaatttct gaaaagcttt ctgcagatac atttcgctta ctgccataga 1915741 tgcttcaatt gcatctgttt ttttgatttc ttcaatgatt ggttcaagct gttcctgcgt 1915801 tgtctcactg ttaatcaatt taagctggtt ttttaatgca ggatttttca gggcatacag 1915861 cactggcaat gtgacgtttc cttgaagcaa atctcctcct acgggtttac ccagctcttc 1915921 ctcagttgaa gtaaaatcaa gaatatcatc aataatctga taagacatgc cgacgtaata 1915981 cccaaaccag tacaatgcct tatgaatctt ctcatcagct ccagacgcaa tggcaccaag 1916041 ctggcagctg accgcgatca agagagctgt ttttcttttg atacggcgga gatacgttct 1916101 gagattttgt tccatgttgt atttgtcttt gatctgctca atttccccta gacaaacttc 1916161 aacgatcgtc tgtgacaaaa tcctatgggc tttcggttcg ttaattctcg tcatcatttc 1916221 aagagatccc gcaagcatat aatcgcctgt gtacatcgca atacgattgt cccactttgc 1916281 tttgattgtc ggttttcctc ggcgaagctc tgcatcatca atgacatcat catgaaccaa 1916341 agatgccatg tgaatcattt ccagagtgac ggcgacatat ttaatcttat taatatcata 1916401 atcgccaaac atgccagaaa gcagcacgaa aacaggccga atacgtttcc ctccggcctg 1916461 cagcaggtga agacctgcct cgcttaaaag cgggtaatcg gaacgtacgg tttgttcaag 1916521 ttctctttcg attacatcaa tatcgtcatt taaaaaagag taggccattt taaatttcat 1916581 atcattcacc caaacatctg tgttttcatt tccatccgat atgcgtggca gcgactccgc 1916641 cagtaaacga atgatattta acatttttca ggcccgcctc ttcaaacagg cctgccagtt 1916701 ccttcattcc agggaaatct ctggctgatt cttgaagcca agaatattct ttatagctct 1916761 tcgcaaacag tttcccgaaa aacggcataa tatacttaaa gtacataaag taagcctgtc 1916821 tgaatccgaa catttccggc tgggacgttt ccagacatac cacctgcccg cccggcttca 1916881 ctacacgtct catctctttc agtacagtca agtaatcagg gacattgcgg agtccgaagc 1916941 caatggtgac ataatcaaat gtatcatcat caaaaggaag ctccatcgca tttccgtgca 1917001 gcagttcaat ttggctgaat ccgccgtctt ttactttctg ctcgccgaca ctcagcatat 1917061 tttcactgaa atccaagccc ttgatctcgc cgcttttgcc tgccgctttt gcaagagcga 1917121 tcgtccagtc agccgttccg cagcagacat caagtgcttt tgcgccttcc tttacattca 1917181 tgatgcgcat cgttttgtcg cgccattttt tatgctgctg aaaactgatg acagagttca 1917241 tttggtcata atttttatat attttttcaa atactccgtg tacgcgctgt tcttttgagt 1917301 cctgcataat ggtttaccct tcttccactt tctgatgata ggtttgatct tggctgattg 1917361 tcttcagacg gtttattaaa atgttctgaa taggtgaatt tagaggcaga agtgactcaa 1917421 tgctgttttt cgctttttta aaacaatctt ctaatatctc ttcttttgtt tttcccagct 1917481 gtataaaact gccgatcaca tccagaaatg catcatttcc gttcataagc cgcttaaata 1917541 caaaaaaatc actcgacagc tttttccagc gcgggaggtt gaagtgttcc gccacacgat 1917601 ggaataaagc tgattcaacg atgccgacac tttcgaaaaa atcgttttcg tccttgaaag 1917661 aacggtcata cagacgaatt ttatgttcgt tgatttcttt aatggctgta gcaagcgtcc 1917721 gaatcatgta gatatccttc atttcagata gtaaagagta gtacagcccg ctgaaataat 1917781 cgcccgcgag aacagtcaat tggcggtttt tgttttcgtc tcgttttatg actctagctg 1917841 tcgtcacttc atcatgggta tcaagggcgc tttgtacaag catcgctgtt acaatataat 1917901 tttctctgtc gttgtttttt atgtcggctt cttcaaataa agcatgaaaa agaagaagct 1917961 tatcctcatc aattttcggc gcagaaatat gcttcgctaa ataaggatga gacagctttt 1918021 gttttaattt cgtgttcaga ttggctaaag ttccgtagat gtcttgcaaa aatatcaccc 1918081 ttgtccccaa attcacattt atttcttaat ctatgtatga gttttatctt ttcattcgct 1918141 tacgcaggta tcattatagc ataaaaaaaa gaaattggct gtatcctccc gctgtttgcg 1918201 agcatttgct tttaacagcg gggacagcca gcttattttt tttcgctttt catttctccg 1918261 tacgcggttt gaatcagtgc ctctcctctg actttaatgg cagaagtatg ctctgtaaac 1918321 tgagcgatga tcacttctcc cttgtcgagt ttttcggaat ggtgaaactt tgtgtctgtt 1918381 cctcttgtca ggccgatcac attcactccg tcctcaacgg ctttaatgac gacaaaatca 1918441 cttgaatgct tttggttcat ttatagcacc ctctatcttt attagtcctg gcgtttaata 1918501 tgttccaata cttctgcacg ggcagcggca tcatctttaa aaacgcctct gactgctgaa 1918561 gtcacagttt tcgcacccgg ttttcttaca ccgcgcatcg tcatgcacat gtgttccgct 1918621 tcaaccacta ccattacgcc atgcggatca agcgtttcta cgatgctttc tgcaattgta 1918681 gaagtgatgc gttcctgaag ctgcgggcgc tttgcaacgg cttcaacggc acgtgccagt 1918741 ttgctgagtc ctgtgacctt tccgcctcgc gggatatatg caacatgtgc ttttccataa 1918801 aagggaacaa ggtgatgctc acacatagaa tgaaacgcta tatcttttac aagaacaagc 1918861 tcctcatggt tttcaccgaa gatagtctgg aaatgttctt ttggatcttc attcaagccg 1918921 gagaatactt cggcatacat ctttgcgact cttttcggag tatcaagaag cccttctcta 1918981 ttcgggtctt ctccgatcgc ttctaaaatt tgacgaacag cttgttcgat ttgctcttta 1919041 ttaacttctt tcatgttcta tgtcctccac caatgaatac atttaatttc gattctagca 1919101 catatgcccc gctaaaagca aagtgaatgc cctgtcagga agcccatgct cttgaaatat 1919161 gaaaagcccc ttagaaaggg gcttttctgt gaagaaataa agtgtatgta agctagatgc 1919221 atacacgatc tatattcaca attattttcc ggcaactgcg tctttaagcg ctttacctgg 1919281 tttgaaagca ggtactttgc ttgctggaat ttcgatttct tcacctgttt gaggattgcg 1919341 tcctttacgt gcagaacgtt cacgcacctc gaagttacca aaaccgatca gttggatttt 1919401 atcaccgttt ttaagtgcat ctaagatcgt atcaaaaaca gagtcaactg cttttgtagc 1919461 gtctttttta gacaattcgc ttgcttctgc aaccgcattg ataagttctg ttttgttcat 1919521 gcctttcacc tcctcccaaa aggatacatt cagttcgttt attatcattt cttcacagtt 1919581 cagtctgatt ctaaacctgt ctcagaaaaa aatgagagca agtaagagaa agacaattaa 1919641 acggcttttt aagaaaaact gcactctgag gaatgtttgt ccaacaaagt gaagaatttc 1919701 tgtatgtaga gtaacacata taaaaagcca tatcaagcat tttaaagcgt caatcccttg 1919761 ctcgtcaagg atttaaggtg atttaccgaa cgaatattcc tttttttcct tttttcatcc 1919821 tattccttga tccttttcca ttattaagag caaagaaaaa agacctccca ttctataaag 1919881 aggtctaccg gtattacagg atgatggcga ttaagccgcc agagccttcg tttatgattc 1919941 tttctaatgt ttcttttaat ttataccgtg cgttttcagg catcaatgac agctttgcct 1920001 gaatcccttc tctcacaatt gagctcagcg accttccgaa gatatcggaa ttccagatgg 1920061 agagcggatc atcctcaaag tcctgcatta aatagcgtac aagctcttca ctttgttttt 1920121 ccgttccgat aatcggggcg aattcgcttt cgacatctac tttgatcata tggatcgacg 1920181 gagcgacagc tttcagcctc acaccgaatc gcgagccctg ccttataatt tccggctcat 1920241 cgagactcat atcagctaaa gcaggcgctg caatgccgta tcccgtctgt ttgaccattt 1920301 ttaaggcatc agacacttga tcatattctg ttttcgcatg ggcgaagtct tgcatgagct 1920361 caagcagatg gtctcttcct ctgatttcga cgcccacaac ttcttttagg atttgatcat 1920421 atagatgatc aggcgcgtac aaatcaattt ctgccacccc ttggcccagc tcaattccgg 1920481 ctaatccggc actttcaatg aattcaaact cgctgaattg gccgacaacc ctgtctacgt 1920541 cccggagccg tttaatatcc ttaaccgttt ccttcacgga ctcctgatag ctttcacgca 1920601 accaatggtt ttctttcagc accattaccc agcttgggag attgacattc acttctagca 1920661 ccggaaactc gtagagggcc tctctgagca cactcagcac atctgattcc cgcatgctct 1920721 ctacactcat tgccaatacc gggatatcat atttttcgct taaatcctgg cgcatggctt 1920781 ccgtttccgg gtgatacggc ctgactgagt tgatgaccat aataaaaggt ttgccaacct 1920841 ctttcagctc ttcaatgact ctttcttcag cctctatata gtcacttctg gcgatatctc 1920901 caatggtgcc gtctgtcgta atgacaactc cgatggtcga gtgttcttga atgacttttc 1920961 gtgtgccgat ttcagcagcc tcatgaaatg ggatcggttc ttcgtaccaa ggcgtattga 1921021 tcatccgcgg cccgttttca tcttcatatc ctttagcgcc gggcactgtg taacctacac 1921081 aatctactaa tcttatattc acatcgagtc cgtctgacac atgaacagac atcgcctgat 1921141 tcggaacaaa tttaggctct gtagtcataa tggttttgcc ggctgcgctc tgcggcagtt 1921201 catcctgcgc tcgggcccgg tctgcttcgt tactgatatt cgggagcacc acaagctcca 1921261 taaatttttt aatgaacgtg gattttcctg tacggacagc acctacgact cctaagtata 1921321 tatcgcctcc tgttcgttca gcgatatcct tgaaaatatc gaccttttcc aagtgatccc 1921381 ctcccggact tcctatcctt ttcaatttta ttaagctctt tcaatcaaac acaggacact 1921441 atatgtgtat gacgttgtcc tatttgaata tgacatcttt agaaaatttc tcatcctcaa 1921501 tctattaata taaaaaaacc tttctcccta tttgtatgca agggagaaag gttcattcct 1921561 ttttcatatc attttctaaa aaaacaggtt cctgtttgtc atttaccgta tattttacag 1921621 aaaacgcggg gacaaagggg gtttcatgcc aaatcatatc ctggatttca gtcccgggtt 1921681 taaacgtttt tttgcttttt ttgaggcaag aagccagctc agtccggtaa tcggcatata 1921741 tttctccgtc tccgtcaatc ataagcggca aggaattccc tgagattggg cttgtcactg 1921801 taagagagct gccatcccca agcttcttct catcgagtgt aaataaatca cgagatagca 1921861 catccttgta aggcggatat tgatgctcct gacgatacat ttggatgcgc aatttcacat 1921921 cgcgaatttt ttctgccatc tttagatcaa ttaatttaac agtcggatcg ttctctacgt 1921981 caacaagcac gtattgatag tctcccccgc tttcaaatgc cgtacttgga ggttcagcta 1922041 tgtatcttgg cgctaaccgg ttaaagtcta tcggatattt ttgatatagc ggtgtcgaca 1922101 tatctttggt ttgaatagga agcagccctc catttgcctt ttgaaattca tcaacagcag 1922161 attgaacctg ctttagctgg tcttgataag gaatggcatg cacactgctt ttccgttcat 1922221 ttggatataa acatccggat aaaaacacga ctgccgcaaa aatgattgcg cacttcagtt 1922281 tacccataca gcacttcctt ttacagcttt attcattgac agggccgcta aaaaccacga 1922341 caaacacaat aattccagat atgagcatac acatgtatgc gaatgatgaa atcgcaatct 1922401 tcaaaaaacg gttttggcac ttaaagcggc ttaaatagat ggaagctaca gccagaaaca 1922461 tcagacccat ggaccctaga gcaaaccaca ttttcatcaa tgccagattc aatgacgtgc 1922521 gcctccccga tatgtaagat ataagcgtta tattatattt taatatacag cgccggaaaa 1922581 gatcaaccag attttccatc cattgataga acaaaaaaac tgaagcaaag agggggacct 1922641 tcgcttcagt caacttgact atattcacct gcacgtttaa gaaacactct cttggacttc 1922701 gatgctatag tatgcgactt ggcatacaga tgcatcctct attgcctaaa tcggcaaaat 1922761 gtttcaggag atcccaagac ttgggtgttc ttctgttttt cgggctttcg ttcaattaag 1922821 atatgcgatt caccatttga ttgacacttt tacttcactt gattttcaaa cgtatttacc 1922881 aaatcctcca tctcgtgggt tttccctctc gccattaaag attcaacagc ggtttccact 1922941 ttttgtccgt tgaataggac ctgatggaga gcttctgtaa tcggcatttt aacatcatat 1923001 ttcttcgaaa gctgataagc cgctttcgtc gtgcggacgc cttcgactac cattcccatc 1923061 tcttcaagaa catcttcaag cttgtaccct tttccgagca aattgcccgc acgccagttt 1923121 ctggaatgaa cacttgtgca cgtcacaatc agatcgccta ctcctgtcaa tccagagaac 1923181 gtcaagggat ttccgcccat tttcgttccg agtctcgcga tttcggcaag tccgcgtgta 1923241 atcaaagcag ctttggcatt gtcaccgtac cctaaaccat ctgtaattcc tgcagcaagg 1923301 gcaataatat tttttaaagc ccctccgatt tcaactccga taatgtcagg atttgtgtac 1923361 acccgaaaat tgtgattaat aaatagatcc tgcacctctt ctgctgccct catgctcttt 1923421 gaagatgcag taacagttgt ggggtgccgc agccctactt cttccgcatg actcgggccg 1923481 gaaaggacaa cgatatcttt tctgacatca ctcgggagct caatttccat aatttcagaa 1923541 atgcgcagaa gtgaatctgg ctcaataccc ttgctgacat gaacaaagac tgcctttttc 1923601 gttataaaag ggacagcctg tctcagcact tcccgaattg cttttgtcgg gaccgcaacg 1923661 ataatgacat ctgcgtctga aacagcctct ttcatatctg ttgttccttt aatggatgta 1923721 gacagcttaa cattcggcaa ataatctttg ttttcatgca actcattaat ttgatgaatt 1923781 aaatctgcac ggtgagccca cacacacact tcatttccat tatcagttag aactaaagcc 1923841 agtgctgttc cccaactccc cgctccaagc attgtgactt ttttcatgtt tgattcacac 1923901 ctttttattt tctagctctt gcaaatattt tgattggtgt cccctcaaaa ccgaacgcgt 1923961 ctctgattcg gttttctaaa aaccgttcgt atgaaaaatg catcagttcc ggatcgttta 1924021 caaacacaac gaagcttggc ggctttaccg acacttgagt cgcatagtaa attttcaaac 1924081 gagaaccgtt atgagtcggt gtcggattca ttgccacagc gtccatgatg acatcattta 1924141 agacgtttgt ttgaactcga agtgaatgat tttcactagc tttgataatc gcaggcatca 1924201 gagtatggat ccgttttttc gttaaggcag acataaatag gattggcgca taatccagaa 1924261 attgaaaatg atcgcgaata ttttcttcaa attctttcat cgtgctctca tctttgtcaa 1924321 cagcatccca tttgtttacg acgatgacga cggccttgcc cgcttcgtgt gcataaccgg 1924381 cgatacgctt gtcctgttca ataatgcctt cttcgccatc cagcacaacc gccacgactt 1924441 ctgagcggtc aatcgctttt agcgcccgca gtacactata cttctcagtc gtttcataga 1924501 ctttcccttt ttttcgcata cctgcagtat cgacaatgac aaactcctgc tggttgtaag 1924561 taaatgacgt atcaacagca tctcttgtcg ttccagccac gttgctgaca ataacgcgtt 1924621 cttcgccgag catcgcattc acaagtgaag actttccgac atttggacgt ccgatcagac 1924681 agaattgaat aacttcttca ttgtatttcg tttcaggaat gtttttaaaa tgctctgcaa 1924741 cggcatccag taaatcaccc agtccgagtc cgtgtgttcc cgaaattgga tacggctcgc 1924801 caaagcctag cgaataaaaa tcataaatat tcgctctcat ttctgtgtta tccagtttat 1924861 taaccgctaa aacaacaggc ttttttgtgc ggtacaaaat tttcgccact tcttcatcag 1924921 cagctgtcac gccttcacgg ccgttcacca taaaaataat cacgtccgct tcatccatgg 1924981 cgatttcagc ttgctggcga atctgcgcta aaaacggctc atcaccgata tcaataccgc 1925041 ccgtatcaat caaattaaaa tcataattca gccattcagc cgagctgtat atccgatccc 1925101 ttgtcacgcc aggggtatct tctactattg aaattctttc tcccgcaatc cggttaaaga 1925161 ttgtggattt tcctacattt ggtctcccga caatggctac gacaggttta cccatagtac 1925221 ccttcctttc aatccagccg ctttcatttt tacataaatt ttcaaccggt tattaaaatc 1925281 atttcattca cttttatgaa aagaaaccct tcagaggaag ggcttaactc atttattata 1925341 tcagttttta ctgggatcac aactattctt aaaaatgttt cacgatcaaa tacacgtcat 1925401 ctccgattct gtgagctatt ccatcaagga tcgcctcaag atttttagcg aaaagctcca 1925461 tctccttttg gtcattgcaa aaaaagacag gtgctccccc tgcaacccga tttcgatttg 1925521 tcgtgattac agacaaaatc actttcgtaa gagattcact catcctatca ccttatcctg 1925581 attcttgata aattcagtcg gcattctaat cgcattttcc agggttggaa cattgctaat 1925641 aatttgaaca gccgtttcgg gatggtgaat ttgcgggaga acaaatactg ccactctccc 1925701 atcatttaaa tcccgttttg caattggtgt caaagatggc tctcctgaat cccgataaac 1925761 cccgagcaca ttggaaacat caaataaaat ggcctgacgc tgccctaaat ttgctatcgt 1925821 cgctgctgaa ttaaagtttt tcggcgtcaa aataaagccc atgccatgct ttaaaatcag 1925881 ttcctgtttc tctggaagcc cgatattcat catataaata ttatcaacaa acagtcccgg 1925941 accgtcaaag cgcggcttta tgtactcgat atctacaata tccttcaaca cactgcccga 1926001 cataaacttc atggccagta aaaaacaaac gacagccgct atgactgcag cccagatgga 1926061 taaaaacaca tacgcagagg ttgtcaaaag cgctgtaaag atcacaatat aatttctgct 1926121 ttcaaacgca atggcaatcc cctcaatata tgtgcttccc cttgagacaa gttcatacga 1926181 atccatttgc gtcaatgtgt tccgctccat gtttcggaca tctctaaatt gcgtcgctgc 1926241 caatgttaaa aatgtgatgg ccgtaaattc ctcctgcaaa agcgccggca taataattgc 1926301 acctaaacca gccgctatca accccagtgc gatgtgaatc actttcccat gaacataggt 1926361 cggatactgg cggtaatccg ttttcagcat ataaagcctt gtcgcaattc cggcaatgac 1926421 cccagcaata atcggataga tgtaatcact catgacattt tggtagctcc tttgtttgat 1926481 cttttgcttt tctgaccaat ctggcttgcg aggtgttcgt atttagatat gccaaacagc 1926541 aatatcatcc ccgcagaaca cgcattcagc cattgaaagc cgccgacagc catagccccg 1926601 gccaacttct ggatcacaaa tgaatacacc agttcgcctt ggcacatccc taggacaaat 1926661 aagacaagct gcttctcaaa attcctttca acagaagctg ttaaaagcac tattaatata 1926721 acagcagccc actcaggttt tatgatgaac caaaccgggt catataatgc aaaaagataa 1926781 acaaacgcat acgcggcaac aagcgtcaga tagaccatga tgtaacgaaa acgatacatt 1926841 cccaaatacc cggcatagac acatccgcaa acgaaaaaca tcaaatatgc agcattcagg 1926901 gaaaaatata aagcgatgtc atgtatgctt agaataatat tagttaaaat aaagacagag 1926961 acggcaattc gtcttttcgt cttttcaaaa ataaatgttg tcagaaccca cagaaaccac 1927021 attgaccaat agtaataaaa ttgttccatt ttacttcctc catattccca gtatggagtt 1927081 caagcacatt ttttaaacaa tcgatctcac attaaggagt atgatcatgg gaaaagacag 1927141 acaagagaaa aaactcaaag cttcaggcag agtcgaatca gatcgcgacc agtccattca 1927201 ctatgacgga gcgacaagcc ttgaacaaaa cggaagattc aaaaagcgaa aatcataata 1927261 caaaaagccc aaaccacata tggttttggg cttttatcat ttatcgcaca ctatagcttg 1927321 atgtattgac ccctctctct gtgagccaat gatgggtttc acctttgatc acaaggggcg 1927381 ccttttgtaa atcggcaatt gttctggcac ccagcacggt cataatcaac tttaattcct 1927441 caaggatcag ctgaatctcc tcaagcagtc cttcctcacc gctgtcagtc agcgctttta 1927501 aaaaatgccc tgccattccg gtgcaagagg cccccagcgc aattgccttt gccacgtcaa 1927561 gcgcatcttg cagaccgcca gaggcgatca tggtgcttgc aggaaactca gagcggattt 1927621 ccgccaaact tgcagctgtc gaaatgcccc acgaattaaa aaaggagatt tgccgctgtc 1927681 ttcggagatt ttcgattttc gagaaatttg ttcccccgta accgccaatg tcaacagctg 1927741 cagcaccagc ttcatacagc tttcctgctg atgctttgct cataccgaag ccgacttctt 1927801 tcacaatgac cggtacactg acccggctgc aaatttgttc aatgcgtttc aatgcgccgc 1927861 taaagcttct gtccccttca ggcatcacaa tttcctgaat cacattgagg tggatctgca 1927921 gtgcgtttgc tccaatcatc tcaacggctt cctttgcctg agcagccgtt gcctcgcttc 1927981 ccaggttggc aaaaatcagc ccgtttgggt tttcctttcg aacaatttca taggaaagac 1928041 gctctgatgg atcttttaat gctgacattt gcgatcccac agcaagggga attccagcct 1928101 gagaagccgc tcgcgcaagc gatttattaa tctcatatgt aagttttccg ccgccgccag 1928161 tcattgcatt gataaaaatc ggcgaactgc ttgaaagttc gccgattttt gtggaaatat 1928221 ctacttgttc taatgcaaga tcgggcagac tgacgtgaac aaacgtaata tcatcaagac 1928281 ctgtttcccg cttctggccg atggacaagg catgattgat gtgttgtctt tttcgttctg 1928341 ctcgagtcac gtttatcacc aattatttta gtttattcag cttatctccg atcagatctc 1928401 caagctggaa gccagtgctt gtttcttcct tcgcttgata ttgacggtaa tcttcctggt 1928461 cagctttagg cgtttcttca agttcacgca tgcttaatga aatgcgctcc tcattttcat 1928521 tcacatcaag aaccttcact tttacagtct gtccttcttc aaggacttca tgcggcgtgc 1928581 cgatgtgttt attggaaatt tgagaaatat gaacgagacc ttcaacacct ggaaggattt 1928641 caacaaaggc accgaagctt acaagacgct gtacagttcc ttcaagcaca tcgccaggct 1928701 tcactttttc gccgatttgg ttccaaggtc caggcagtgt atctttgatc gataaagaaa 1928761 tacgttcatt atcacggtca accgataaca ctttcacttt tacttcttgt ccctcttcaa 1928821 caacgtcaga cggcttctct acatgagagt gggaaagctg tgaaatgtgt acaagtccgt 1928881 cgatgccgcc aatatcaaca aacgcgccaa agtcagtcag gcgctgtact ttgccatcaa 1928941 gtacacttcc aacttcaaga gactgaagaa gttcttgttt tttattcgct tgttcacttt 1929001 caacaacagc acggtgtgaa aggatcacgc ggtttttatc acggtcaagc tctacaacga 1929061 gcagtgacag tgtttttcct ttatagtcag tgaagtcttc aacgaaatgt gcttcaacaa 1929121 gtgatgccgg aataaaaccg cgaacgccga tatcaacgac aaggccgcct ttcacgacat 1929181 ctttcacttc agcttcaaac acttcttttg tttcaaattt tttctcaagg tcttcccaag 1929241 cgcggtctgc atcaacagca cgtttagata aaatcaaagc atcgtcttcc acttttgtta 1929301 ctttcaggtc aagctcgtcg tctactttaa caacatccga tgctttctct acatgaagac 1929361 ttgataattc actgattgga ataataccgg attgtttgac attgataatt tctacatcta 1929421 catgtttgtc ttctaccttt gtcacaatcc ctttaactac atctccaacc tctggcactt 1929481 gaacatcaat ttgattcatt tcctctgtca tttgaataac ctccttggtc caaacctaca 1929541 cagcttaatt aaaacggttt gaaagctgaa catataacat gcccgctttt agccgaatat 1929601 gtattaaaga atcatccaaa aaagtttttt gaatgatcaa taaaaagttt tattagtatt 1929661 aacttctaat aaaaggacag gtttgtcaag caataacatt ctatcttcgt tgaaaaattc 1929721 aaaaaaagtg gcatttgcca tcctcagcgg gacttttgct ccacagcctc gaggatttta 1929781 tcagctacct cttgaatgga aagcgatgtc gtgtcgattt caagagcgtc ttctgcttta 1929841 cgcagcggag atacttcgcg ctctgaatca agcttgtctc ttcttgcaat ttcctcaatt 1929901 aatgtttcgt agttgacatc aaagcctttt ttcacatttt cttcataacg gcgtttcgct 1929961 ctctcttcca cagatgccaa aagaaagatt tttacttctg catttggcag cacatgcgtc 1930021 ccgatgtcac gaccatccat gacgacgccg cctttttccc caagctgctg ctggcgtttc 1930081 accatttctt ctctgacact tctgtgcttg gccgcaattg aaacttggtt gctgatttca 1930141 tctgttctga tcgcctcagt tacatcggtg ccgtttacaa acactttttg tccatctttt 1930201 gttgtaatca gctcaatgtc tgtccgcttt agcagctcag ccagtttttc ttcatctgtc 1930261 agatcaacgt tttcctgtaa agccgcgtac gtaatcgccc gatacatcgc tcctgtatca 1930321 atatatatgt acgatttttt ctcagccaca attttggcaa cggtgctttt ccccgcagct 1930381 gccgggccgt cgattgcaat cgataatttc ttttccataa ttcctctcct tgctcttttc 1930441 tcctctaagg attgtatcac gaactttatg aaaaagggtg aaaaattgat gaataattaa 1930501 tgtttgaagg tttcaatcct attgttttcc tccattttat ccaccccttc atattgaatc 1930561 acttttgata cgtatggttc aatatgctga tagtgaaaaa gaaattggac accaagtaaa 1930621 atgatggcct gaatgaacaa taatttgatc agcagccgtt caaatgtttt cattggagca 1930681 cctccattac aaatagtatg gaagtgtttg ccgatgttta ttccattcgg gcctttcttc 1930741 tcttatttaa ctggcgcctg atgcagtatt gaagcaaagc ctgctggtca cctgctgcaa 1930801 tttctgaata ctctaaagtc atttttcgtt tttctgactt ggggtcatta aagattcgtc 1930861 tgacaactgc ttctgtttct atttgacgtg tgtgctcctc ttcaggaaga cggatgatca 1930921 ggcgcaatga ttcccccgat tgaaaagaaa ggccatcagc taaaaccacg gcgatgccgc 1930981 ctgcactgat gttataggat agtgtgcgga tctcttcttc atttcccggc tgaatttgca 1931041 catctaatac cgcatcagtt cttacatatt ggcggcgctg gattcttttc attttttcac 1931101 ggggaggcat ttcaagacag atcatttgaa gtttgtcctt cactttacct tttatacggc 1931161 ttataaagcg ataaggaact tcgtcttttc ccacaaactc taccgttact tccatatcgt 1931221 tatgtaaaat cacagttcgc cctgtaacta catcaacagg atacgcgatc aaaagttcat 1931281 tgttttcgat gctgaccgcc ttgctttttg cctttttcaa ttcattttct tctatatatt 1931341 ctaaaagtac attttctcca atctctatca ttgacttcac tctttcgcat tcaatatact 1931401 cacgttttta ttaaagcacg taatgaaaaa aaggaaaaga catttagtcc tttcctcctg 1931461 tttttatagg tctttatata taggttctgc attttttagt ttttcaacct tttcttccga 1931521 tccgtctttg gcattgatat acattctgaa tgtgtcattt tcaattgtcc caagcatttc 1931581 gtagcataac acttcttgac ctagttcatt tgtaatcaaa gcgagccttg tttctctcac 1931641 ttgtacattt ttatttaatt tagactttgc ctctgcttca gtaattgcag gcttaggtat 1931701 ggttcttttt ctgtgagatg tgaggaagtc tcttgctgaa aagccgacaa cctcaccgtc 1931761 atccaaggcc actttcatac gaattgcctc ggggtacatc cggactttat tttcaacagg 1931821 aacatatgaa aatacaccga ttttatcata ttgggcactt tcatcaattt ccaaatcatc 1931881 tgtttcaaat ccgtttttct ttaaaaatgc aagcgctcgg ttcgatccgt catttaaact 1931941 gattttctga tctttcactt ctctgttttg gatcaagtat accggatgcc cgcccttctt 1932001 cgtaatatcc atataaatca ctgctttatg gtctgggtct ttcatgctga tgctatatac 1932061 atcgcgattt gttttttttc cgctctttac cactttaatt gaataattgt catctggggc 1932121 aaagcgctca gcaatttgtt ttgcttcctg ttcggaaatt tgttttccct tcagatggct 1932181 gaagcctttc tcttcttttt tcgtactggt gaaactcggg ccaagatcag tgccagtgga 1932241 gaatgcacca acattttttt cgactgtttt aaagctgttg ataatcgtat tatcactttg 1932301 tttttcgtca gaagccagag ccatttctac gtccatccag cgaaggtttt tgctcatgac 1932361 aaggtgctga acatgacgca attcattttg tatatcttcg gactgctgat atagcttatt 1932421 tagtgatgta tactcgtttt tatcaagcgg cttttggtcc aaatctctga ctgacgtttt 1932481 atagctgaaa tcgccgatct ttgataatag ctcttcagtt ttattaaacg gcattaatgt 1932541 aagcggcagc tgactgacgc tgttatgagc ttctgatgta atcctccaca catcgatcaa 1932601 tgcaggcgac agtgattttt ggctgttcat ggcaagtgtt gttccgattt tatcatgaag 1932661 ctgatccacc tgataggtaa gctcatgaaa cgcccgctga tagttatttt cagcatgaag 1932721 aagaactgcg tctttttcct ggtgttcttt gtatccccag tagcctgtac cgactattgc 1932781 aataccaagc acggcgatta aaattcctct gatcatttat cacacctctt tttatgcttt 1932841 ctcatatctg ctactcacag aaaatgtgtt taccgattct tttaatctgc ggacgccccc 1932901 aaatccacgg acttgtagcc gtatccggat taaagtagta aagtgcttcc tctgatgggt 1932961 cccagccatt gatggcatcc agcactgctt ctcgtgccgt ttcattcggc tgcatgtaaa 1933021 tttgtccgtc ggctactgct gtgaaggcaa gcggctcaaa aataaccccc gctactgaat 1933081 ttggaaataa cgggctgttc aaacggttta aaatgactgc tgcaatagca acctgcccct 1933141 cgtacggctc gccccgggct tcgccataaa ccgcttgagc aagcagcctg atatcgttgt 1933201 tggaaaatcc accaggcatg ttcgctgcta ccgcatcctg ttttcttgct tttgctggtg 1933261 tattgttttg ctgtttattc gcattcgctt taggcttctg cgttgttttt tccgcaggct 1933321 gtttctgccg tgcttctgct tgttgtcttg ccttttgtgt tgctgctttt gatggtttcg 1933381 tctgatactt tagcggaatt tttccgtaat gcgtgaatgt attcccttta ttgagctgtt 1933441 ccatgacata ttcacgatag tattttgatt tacatattaa ggtttgcttt gttttagctc 1933501 ctacaaggcc gtcaacctct tttaacccga attgatcctg aaaatttcga actgcccagt 1933561 acgtccccca tccataaacc ccgtcaattt ttccgttata atatccgttg tattgaagac 1933621 gcgcctgaag ctcgaccaca tcatcccctg ttgcccctct ttgaatgacc tgattcgaaa 1933681 aggcagagat cgtttcagta ttaataaacg tcgttattgt aaaggaaaaa aggatgagac 1933741 atgccataat cgatcctttg gacttcatct tttcaagcct cctactgcaa atttttaagt 1933801 gtaatcgtat tttctgtaac gaggttattt ttatacactc tttccttgtt atccctcaga 1933861 acataaaaac tgcacacaaa aaagccgcac ggttgctgtg cggcttctat acttgcatca 1933921 tattaacgga acgggctttt ttcgctttac gcaaaccaaa ccaccataaa aataccataa 1933981 atggaagcat ataataaatc caattgctaa gcgctgttag gataaaatca tatgatccat 1934041 gcaaaaggga tgggacaact aaagaaagag taagccactt tacacgcgcc ttatcagcgg 1934101 aaaaacgggc ttttccaagg taaaatccca ttataacgcc aatcaaggca tggcatgaaa 1934161 caggcagcag cgccctgaca aacgcatgct ccacgccgtg gccaattaaa taaagaatat 1934221 tttcgagggt tgcaaaaccg agtgatacac ttgcaccgta cacaatcccg tcataatgct 1934281 catcaaagtg ggcgtgcggg taaacactga tcatcagtat aaaccatttt aatgattcct 1934341 ccaaaaaccc cgaagataaa aaagaaacga aaaagcttcc gcctcctaca ttctcttttt 1934401 caagtacata ctggataaac atgatgggaa atacaagaac aaccccgaga aaaaacgacc 1934461 gtagcaccat atgtacaggt tcattatcat actgatcttt taaataaaaa taacttaata 1934521 acgcgatgcc gggggcaatt cctgcagaga tgattgcaaa catcaggcaa cctctttcct 1934581 ttatattcct acatctatcc taccatgttg tttaaaattt tacatctgtc tgcacttaaa 1934641 aaaacaaaaa gagcatacga atgcatcata tgctcctcat ctttaatggt tttctctttt 1934701 ggcgatttcc gctgcgatat gccccccgtg aaacctgccg ttttcaataa atatttcatt 1934761 tgcattgttt cccgcagcaa taacaccggc aataaagaca ccttcaacgt tcgtttccat 1934821 cgtttcttcg ttgaaaaatg gacgccctgt ttctttatca atttcaacac caattttttc 1934881 aagaaattga tgatcgggat gatagcctgt catggcaaat acaaaatcat ttttaatggt 1934941 aatgagttct ttctctccgg agcgaaacac aacttcattc tcggtgattt tttcgacaca 1935001 agctccaaat tccatacgga ttgtaccgtt tctgacgaga gcttcaaatt ccggcagaat 1935061 ccacggctta atgctcggag aatactcatt gcccctatat aaaactgtga cacgcgcccc 1935121 agatttcacg agttcaaggg cggcgtccac gcttgaattt ttcccgccga tgacaacaac 1935181 atctttatca aaatacgggt ggccttcttt aaaataatga aatactttcg gcaaatcctc 1935241 accgggtacg cccatatagt ttggatgatc ataatagcct gtggcgatga tacaatatgg 1935301 cgtcgtgtag gtctcttttg acgtctcaat aacgaatgtg ttattttgcg ttttcgtcac 1935361 tttacgcacc atttcaaacg cattaacacg gatgtttttc cgtttaacga cttcccggta 1935421 atacgataaa gcctgaattc tgacaggctt cctgttctct gtaataaatg ccacatctcc 1935481 gatttcgagc ttttcacttg aactgaaaaa ggtttgatgc gtcgggtaat tgtaaatact 1935541 gttaacgaca ttgccttttt cgatgacgag ggcatcaatg ccaatttgtt ttaggtgaat 1935601 ggcagcagat agtccacaag gtcctccgcc tataataatt gctttttctt gaatcatttc 1935661 tgtcaactcc tgcgattggc atttcacttc atattttcta tttccgaata aaaaaatctc 1935721 ctattttatc ataggagatt ttttattttt atgcaaatca tcaacttata tccagcctct 1935781 aaaacgcgaa gcttcagcca ttttgcgaac gccgaccata tatgcagcga gcctcatgtc 1935841 aattcttcgg ttgttagcca tttcgtaaat attgttaaat gatttgacca tcattttttc 1935901 taatttttct tctacctctt cttcactcca gtagaagcct tggttattct gaacccattc 1935961 aaaataagaa actgttacgc caccggcact tgccagcacg tctggtacaa gcagaatgtc 1936021 ccggtctgaa agaatttttg ttccttcaag cgttgttggt ccgttcgctg cttcaacgac 1936081 aattttagcc cggatattat gggcattttc ttctgtaatt tgattttcaa tcgcagcagg 1936141 aacgagaata tcacaatcca gctccagcag ctcttggttg gtaatggtat cgttgaaaag 1936201 ctttgttacg gtaccgaagc tgtcgcgtcg gtcgagtaaa taatcgatat caaggccttc 1936261 cggatcataa agtccgccat acgcatctga gatgccgaca acttttgccc ccgcatcatg 1936321 cataaatttt gccaaatagc ttcccgcgtt tccgaagcct tggacaacga cacgcgcacc 1936381 tttaatatcg atgcctctct tcttagccgc ttctttaata cagatggtaa caccttttgc 1936441 tgtcgcagat tctctcccgt gagatccgcc aagcacaagc ggtttgcctg taataaatcc 1936501 aggcgaatta aattcatcaa ttcttgaata ctcatccatc atccaagcca tgatttgtga 1936561 gtttgtaaat acatccggtg ccggcacgtc ttttgtcggg ccgacaattt ggctgatcgc 1936621 tctgacatac cctctgctca gacgctccag ctctctaaac gacatatccc ttggatcaca 1936681 aacaattccg cctttaccac cgccatatgg aagatcaatt atgccgcatt ttaaactcat 1936741 ccaaattgaa agcgccttca ccgccttcac ctctttttct gttacgttcg ggtgaaaacg 1936801 tatcccgcct ttcgttggac cgacagagtc attgtgctgc gcacgatatc ctgtgaaaat 1936861 ctttactgaa ccgtcgtcca tacgaacagg tatttttacc gttaataatc tcatcggctc 1936921 ttttaacaat tcgtatacct cttcgggata tcccaatttt tccagagcct tatgtattac 1936981 ggtttgggtt gattttaata catcaagttt gtcctcttct gtatgaccgg tgtttcgatc 1937041 ggctgccatt tgagttaacc tcctagaatc ttctgtttct cacatgctcc ctttcagaga 1937101 atagtataca ccttcatatg atctgtgcat agaataaacg ttatgttttt ccatgttttt 1937161 taacgaaaaa aaactgctga aatcagcagt tttccgttgc attcttatga aaaatgagtt 1937221 tgtatcgttt ctacggcatt accgtccata atgagcttac catactcttg caggcgataa 1937281 atcgttaaag ttgtcggatt gccgtattca gccagaaccg ccacaacccc ttcagccgta 1937341 tgtgacccta gatcttcaag gcttaaaaag tactgcccgt catagtggta gacagttccc 1937401 cctgtgatac cgattcgctg taagctttct gaaagctgaa tgatatcttc aaaggaatgg 1937461 aattgatata tgatgtccgc gctttcatca agcttgactt gcatttcgat gtaatcatca 1937521 tcatactcat cgtcttctga atcggcgtct tggttctttg ttacaatcac gaccatccct 1937581 tgtgcttgga gagaatacac ttccactgca atcggtccat tcgcttcaaa gccgagctct 1937641 gtatttgctt cattcatcat atctttaaat aactggtgga ctttaaatga gtccttccag 1937701 aggtcttctt ttgtcaatcc ccggtctgtc aaatcatcga gggttaaaaa gattttgatc 1937761 ttattataat tcagacgctc aagccgcata acgttccctc ctgcctctac ttgcacacaa 1937821 atcatataac acattatatg agatgatgag tcataggttc ttaattgtta tcagtttaca 1937881 ctgagttcac tagtaagaca agcacaatgc agtttttatt gccatacgga tttttgcttt 1937941 ttagaagtta ttctggcccg caaagagtca caatgtgagt ttcaggctca gcacctaaac 1938001 gaagaggcac ttttgtcgtg ccgtagccgt tgctgatcag atatgccgcg tttttaacaa 1938061 tacctgtttt ccccagttca taaggaccga attttccaaa cctgatctgg cctccatggg 1938121 tatgtccgct gagtatcaca tcaataccgt catcttcatt gatttgttca tgaatctccg 1938181 gattatggca aaccagaata ttcagctggc tttcatcaag ttctttgatg gcttcctcat 1938241 aatgatccat ctccatcctg atatcatcaa cccccgcaat cgcaatcgta tgcccattgt 1938301 atgaaaacgg gactgactca tttctcagag tgatgacgcc gtgcgcttta aatatggaat 1938361 acagcttatg ctgcctgact tcataatcat tattccccca cacaaacacg atagggaccc 1938421 cgaaatgtac gagccttttg atgttttcct cgattctcgc actgggcacc ccgccctcag 1938481 ctaaatcacc gccgattata accaagtggg gggcatggct tcgcgctttt tctaaaaggt 1938541 cttgatcgat gagacgtttg tgaatgtctg aaataaaaaa gattgtcaga ggcggcttgc 1938601 ccttcatctt tgataaagga aacgtatgtg tcttcaaatg attgcctttt gctgttgcat 1938661 acatttttgc cgtcattgcc gctgccgcaa cagttagtac accggcaatt ttcactgata 1938721 gcttcataaa aaactctcca ttctttttag aacttatcaa taagacggac aataaaaaaa 1938781 gacgtttcta tcgtttgaga aaacgcccca ttttatttac tttcaaaata tagattaatg 1938841 tcatatttgt gcttcatcat atgaaaaaca gactctctcg ccttccattt atcgggctgc 1938901 ggccagagat cagtgctttt ctgaataatt tcacatctca gtttatggaa atcagtctcg 1938961 gatttttctt cctttttctt gaaataatat gaagtgcagt aggcaaaagc ggttgccagc 1939021 atccaaaata aataaaaggt atggctaagt atttcttgaa gtataagctg aggctccggg 1939081 cttttgatca tgatcataac acataataag cctaggcaga taagtgaagc ccatcgccat 1939141 ctgcggcatt gtgctgcata attttcgaat ttttgttttc gttttaccag cgcttggagc 1939201 atctgtttgg tcggcgcgtc tgtaaactga tccagctgat tccataagga ttccatacgc 1939261 ttcacacctt gtccattttc attgctacaa tatatgaacg taaaataaaa ataataccct 1939321 attcatccat taaagggatg tccaaaactt gtccggtgta aacatcattt ccattcagat 1939381 gattatatgc tcgaattttt tcttctcctg tccggctttt ataatacttc atggaaatgc 1939441 ggtatagcgt ttctttcttt tggacggtgt gcttgacaac gcgattcggc acattttgaa 1939501 ctggctcagc tggctgttct tgctgttgta ctgttgattg ggaagaggaa gcagccgcgg 1939561 cggttgcttc ctccttattt ggcgagtctt ctttttccgc tacagcagtc tgtttcttat 1939621 cagcagctgt ttgctctttt ggcttggaat cttctggctc tttttttgac tccttctgca 1939681 gtgcggtttc tttagtgtct gcggtatcgt ttttatcctc tgatttcggg acaacctcat 1939741 atttgctttg gctgctgtca ataaaaacat cttcataatc gtcatgatta tccgggtggc 1939801 tctttagata aaataaggtg actaaaacga taaccggcac aaatacaaat attactgcga 1939861 gtactgtgaa taatggcgtt tttgttttgc cttgcttttt tttctgttct ctttgatttt 1939921 ttacagattg tcttgtcgga aggctttctc catcatcgac ataatcgtcc gccaatgcgg 1939981 cgttttgatc ttcataaaga ttctgggctt ttcttctctc tactctcgac atgttcgtca 1940041 tgtttatccc tcctcacatg ttcaaaacga atctgacagg caaacacggc atcaatgata 1940101 aaatgcgccg tcatcggaac aaataagttg ccggtccatt catacatcag accgagcaaa 1940161 aagctgattg ctgtcaccat aataaataac agccattttg acaaataccg aaagtgcaga 1940221 gcggcaaata taaggctggc cgtccataaa ccgatatgag tctgcagcac tcctctgaat 1940281 aacatttctt ccgcgaaagc aatcagaagc gttaaaaata taatatgagg gattgacctc 1940341 ttactgaata tttttttatt gattccgccg tcatcatata aatgagacgg aaaccatttc 1940401 attactgcca tatcggctaa aataacaata acagctatag aaacaccata ccagatgatt 1940461 cgcatatcgc gaatgtccca gagctttaat acgtcccgta catcctcaaa aaagaacagt 1940521 cctgctgcag cagcggcaaa gatgatgagt agctgcgtca aatataactg cttcagcata 1940581 tcatggtcag tcatatgctg aatataatct ttttgctgtt tcagttcagc tcacctacag 1940641 tctgcaagct gaatatccgg tgcaattccg aactccagct gtctaatggc gccattttac 1940701 tccgttcccc tttttgttca tacaaggata aatcaaaacc gcaatgtgaa cagcacggga 1940761 ggtttccgtc atcaggctcg tatgattcat caaagtaggt taacagtgcc tgccttaaac 1940821 agccgtcacg ctgaagcaaa aatgatacac ggtgcatttt ttccagcttc agctccatgc 1940881 gatatgaaat ttctttcttc atcagttcaa ctgatgtttt tccctgcata aagagatgaa 1940941 tcatcatacg ggcctgtgtc tctccgacgc catactgaag taatacgtca cgcagccttc 1941001 tctcatcccg ctcctccgtc ttctctagca cacggattac gtcggcgatt tcttcagctg 1941061 tgacactctc catctggata atttgttcct gcaattcaaa atcccctggc gcccgcagca 1941121 aaatgctgac actcggcttt ccgtcgcgtc ccgctctgcc gatttcctgc ataaaagctt 1941181 ctgccgtctg cgggagatga aaatgaatca catatctgat atcaggttta tcgacaccca 1941241 ttccaaacgc attcgtacaa catatcacat caagctggtt atgaataaac tgctgctgaa 1941301 ttaaaatcct gtcccctgac tccaaaccgc catggtaaaa gtcggctctg ctgctcgttt 1941361 tgcttttaat ttcacccgct aattccttag cccatttccg tgttggacaa taaacaattc 1941421 ccggaccttg caggttttca accagctgaa tgaccctatc tattttttcg gcagtatccg 1941481 ccgcattttc aaccctcagt gcgatgtttg ggcggttgac tgagttgaga tggcgtacag 1941541 catgctgcag ctccagcagg ttcatgacat cttgcagcgt ttcctttgta gccgtggcgg 1941601 tcaatgccag aacgggtggg tgtccaagtt tttttctcag ctgtccgagc tttgaataat 1941661 caggcctgaa gtcgtgtccc cattcagaaa tacaatgcgc ttcgtcaata acaaataggc 1941721 taatcggaac gcttttcaat ttttccaata catatggaga ctgtaaagct tcaggagaca 1941781 agtacaaaaa tttatatcga tgaatatgtt ctaaaacaaa ttgtctttcc tgcctgttaa 1941841 gcatgctgtt caaagctgca gcacgctttt ccccccgggc tttgagctgc tgcacctgat 1941901 cctccattaa agaaagcagt ggagaaacga ttaataccat gccatcaagc atataaccag 1941961 gcagctggta gcaaagcgat ttccctcccc cagtcgggag cattgcaatg gtatccttcc 1942021 cgctgagtat gctttcaata atgtcctgct gccctttttt aaaggaagta aaaccaaaaa 1942081 actgatataa cgtttgctgt aatttagtca tattgctgca cctgctttgt caatgccagt 1942141 ctgatttgaa agtagctgaa ccgctgttcc agcccgtcgc gaatttgttt gattttattc 1942201 gtccgcatcc gtttggcaaa ctctgcgatt tgaagctggt cttctgctga tacatagtca 1942261 ttaatcataa acgcaggctc atggagagaa atctcgacaa tgtggtcttc aatcgtcgct 1942321 gttttcagct ttctgatttc agcaattcgc tgtatcggaa acccttgttt gaccatctgc 1942381 catgttttcc tcgtcgactc tgtcagggca ttatctaagt gcacatcaga aaggagatcc 1942441 tttaacaaag catcttcaca ctccggaaga gaatgaataa aataatgtac cgaagcccaa 1942501 aacatgatat agacatacca ttcgtcttct ttcagcgtat cagcaagctg cctgctcgta 1942561 taaccgatcc gatggtgcga ggttaaggag tagacaaaaa tttgcgctgc tttgttttca 1942621 atctttttca aatgcgcctc aagcatggca aaaaggcttt ttgccatctc tatatgatcc 1942681 gtatgccggg acaggtattt ctttacccag tgaagtgtct tatgatcctt tgtgacaggg 1942741 atatactgcc tgctcccttg ctgtttatgg gataggacct gcacaagcag cgaaagcctt 1942801 ttccaaagca cgccggcagc ctgctgataa tgagcgccgt gacaatgaac gggccaaggc 1942861 cgctcgctaa gggcatgtct caaaactgct gcgccgctgg ctgtcacttt gtatgtatct 1942921 gattcagaca ttggcgcgag atatgaatgc ttttcaagct tgtcaagcga cgcagaaata 1942981 tcgcttctcg aacattttgc cgccattcca aagtattttg cagtctgaaa taagccggca 1943041 tcttgaatgg tctgtgacga tctcttgcct ttgaataggt gaaaaacagc gcttcccgac 1943101 cgttccccgt ttattttgca aagacaatcg agaaccataa tatcgaagta atttaatgac 1943161 aacctatcca cctacattct tcctgacaaa aatcgttgat ttgctctttt tattttaaca 1943221 gatttcaaac agaaatcgac gtttaaagtc atcattaagg gggatgttat gtagataacc 1943281 ccttatgtga taagcattct caatcatttt tctgttgaaa tgtggcagca acatcattac 1943341 aataagtaag aggaataggt gttaaattga ttaaatataa agattgatcc atttgttcca 1943401 ccaagaacaa tctgggaggt tttattcatg gcaaagtaca caatcgtaga caaagataca 1943461 tgtattgcat gcggcgcttg cggagctgct gcaccagaca tttacgatta cgatgatgaa 1943521 ggcatcgcgt tcgtaacgct tgatgaaaac aaaggtgttg tcgaagttcc tgaggtactg 1943581 gaagaagata tgattgacgc atttgaagga tgccctactg attccatcaa agtggcggat 1943641 gagccatttg aaggcgaccc gcttaaattt gaatagaagt aactaaaaaa agctcccgaa 1943701 cgggagcttt tttatttaat ggatatgtgc acttcgctgc tgctcaatcc atggcttaag 1943761 cttgataaaa attagtgaga atacaaccgt aattacaata ccttttatca tgttaaacgg 1943821 caggatacct gcgacgactg ctgtttttag cgcgctgtcg gataatgccg gtgaatgtaa 1943881 aaaccacgtg tatgccggaa gaatcagaac ataatttaaa atactcatta aaatggtcat 1943941 cgctgcagtt cccaaaagca ggctgacagc caagcccttt gctgagttga gttttttaaa 1944001 taagaaagca gtcggtaata taaagagtgt tcctgcaata aaattcgcaa cttgccctac 1944061 aggaactccg gccatgcttc cctgaatgat atactgaaga acatttttta tcgcttctac 1944121 ggcaataccc gccaaaggtc cgtaaatcag aatggcaata attgcgggaa cgtcgctaaa 1944181 atcgattttt aaataatccg gaagacccgg aaacgggaaa tttaacagca tcaaaacaaa 1944241 tgcaatgctg ctcagcatgc tgaccacaac taattttttt actttcactt cattctctcc 1944301 ttttcgatca catcttactc gaaaacggaa aggttctttt ccagccaata aaaaaaccgc 1944361 ttcatatata aaagcggggt ttcgaaaatt aggctaggca aagaaacgtt tgaaaaattc 1944421 aatttcaaaa cgcttatgaa cctccatctt ctcccatcca gactgtactg tcggctccgg 1944481 aatctcaccg aatcctgctg taaagacagc tcgcgggctt agagccattg gctcatcacc 1944541 gccggtaggg aatttcaccc tgccccgaag attgatcata tgaaatttaa ttacattata 1944601 aacgataact ggttggctgt atagagaatt gcttcaaatt aaatatatta cctgcaagct 1944661 gtcagatcat tgatttatta ggctttactt ttatccttta ctgcgtcaat acacgttgac 1944721 actcttttga gaatatgtta aattatcaga tatttagttt gtcaatttag gaggaaatct 1944781 aacgatgttt cgagtattgg tctcagacaa aatgagcaac gacggtttac agccacttat 1944841 tgaatcagac tttattgaaa tcgttcaaaa aaacgtagca gatgcagaag atgaattaca 1944901 tacttttgat gctcttttgg tgcgaagcgc gacaaaagta acagaagacc ttttcaacaa 1944961 aatgacttct ttaaaaattg tcggaagagc cggtgtcggt gtcgataata tcgatattga 1945021 tgaggctacg aaacacgggg taatcgtgat caatgctccg aacggcaaca ccatttcgac 1945081 agctgagcat acatttgcaa tgatctcttc tttaatgaga cacattccgc aggctaatat 1945141 ctcagtgaaa tccagagagt ggaaccgcac agcttatgtc ggttcagagc tttatggaaa 1945201 aacgcttggt attgtaggat taggccgaat cggaagtgaa attgcacagc gtgcgagagc 1945261 gttcggtatg actgtgcacg tttttgatcc tttcttaacg gaagaaagag cgaaaaaaat 1945321 cggcgtaaac agccgtacat ttgaagaagt gcttgaaagt gcggatatca ttaccgttca 1945381 cacgccttta acaaaagaaa caaaaggctt attgaataaa gaaacgattg caaaaacgaa 1945441 aaaaggcgtt cgcttaatta actgtgcgcg aggcggaatt atcgatgaag cagcacttct 1945501 cgaagctttg gaaaacgggc atgttgcggg agcagcgctt gacgttttcg aagtcgaacc 1945561 gccagttgac aacaaacttg ttgatcatcc attagtcatt gccactcctc acttgggagc 1945621 atcaacgaaa gaagcacagc tcaatgtcgc cgcccaagtg tcagaagaag ttctgcagtt 1945681 cgcaaaaggc ctgcctgtca tgtcagctat caacctgcct gccatgacaa aagatgaatt 1945741 tgctaaaatt aagccttacc atcaaattgc aggaaaaatt ggcagccttg tatcacagtg 1945801 catgaaagaa ccagtacagg atgttgccat tcaatatgaa ggcacaattg ctaaacttga 1945861 aacatcgttc attacaaaag cccttctgtc aggcttttta aaaccgcgcg tagactctac 1945921 tgttaatgag gtcaatgccg ggggtgtcgc aaaagaacgc ggcattagct tcagtgaaaa 1945981 aatttcctct tctgaatctg gatacgataa ctgcatcagc gtaaaagtga caggagaccg 1946041 cagcaccttt actgtaacgg ctacgtatat tcctcatttc ggagaacgaa ttgtcgagat 1946101 caatggattt aatattgatt tttatccgac tggtcacttg gtgtatatcc agcatcaaga 1946161 tacaacaggt gtcatcggcc gagtaggacg tattctcgga gataatgata ttaacattgc 1946221 aactatgcag gttggccgta aggaaaaagg cggagaagcc atcatgatgc tttcctttga 1946281 cagacatctg gaagataaaa ttgtgaaaga actaacaaat gtccctgata ttgtgtctgt 1946341 gaagctcatt gatctgccat aattaaaaaa actcaagcta tatagcttga gtttttttat 1946401 tgttctatcc ccgtgtgttt ttatgcaaaa tatctaagac actccttagc tcagaaacag 1946461 gaatttggcc tggtgcggac gcctcttctc cagctccaaa agtacaagcc gatccaaaaa 1946521 cctcaccgct cagcctgctg atgagccctg ttgcagccat tgacattgta ataatggggc 1946581 ggtctgcata tattgttttc attgtatacg tcgcatcaag cagtgttagg agatctccag 1946641 tatcattcgg catgacagcc atttttggaa tatgcgcgcc taagtcctgc atttttcgaa 1946701 gtctggaaat aatttcatct tttacaggtg ttttttcaaa gtcgtgattt gacatcacca 1946761 catagacgtt gttttcttcc gccagcgata ctaacgcttt tacatttgca tctcctgaaa 1946821 ataattcgat gtctatcaga tcgatgtctt ttgtttggat tgccgattcc agcaaagcaa 1946881 gataggagct ttcgtccatc tccatgctcc cgccctcttt gtgggttctg aatgtaaata 1946941 gaaatagctt gtcttctaaa gatttacgaa gcttagaaat gagctttgtg accgcttctc 1947001 tgtcattcgc tttttcaaat acgtcgactc tccattcaac aatgtccgga ttcagtaatt 1947061 ttactgcctc tgcttcattc agaatttgtt tttccgtctt tcccatcagc ggaatgatga 1947121 ttttcggcat cccttccccg atggaaactc ctttaatcgt taacacgttc actcgtctca 1947181 aatcctttca atctttacct tgttttatta tacacgtaca actttttttt gaaaatttct 1947241 attatatgaa tagcaactaa aaaagagcct taaagggctc tttttagttt aaggaaatcg 1947301 gatttggagc agctggcacc ggaattgcat ctgatatgtc atatttgccg atttttttcg 1947361 ttctggtttc cgtaaaggtc acttctgtga agccaaactc ttttgcagtc aaaagtagtc 1947421 cctcaatcat taaaataccg gcaatagaat catcaacttc tgactccttt gaaaagcgga 1947481 tatataagtg tttctgtttc ttcgttacag attggacagc acccgcttga ataagaggtg 1947541 tcgtatcttc ttggctgctc gattccattt ccttaatcgc ttcttttact gtatcaaaag 1947601 aatgatttga cggaacgaga aagtcttgtc cttgtttatt ttggtacaag tagtaggatc 1947661 gttttgactg tttgggaatc gaaatttccg taaaagtgcc atatgagcca atccgaaccc 1947721 cagtctcatt ttgatccgat aaaaatttga ctttttcata aggactccat tttaaggatt 1947781 ctttaagcaa tttttttaac agtgtatcat cttttataga aaatgccgta gctggctgat 1947841 ggactcgtat acttaattcc ttctgctttg gtttttcctt tatttctact tcatctatga 1947901 aggttggaat tgtaatggca tgatcaagga tgcccaattc actactttca aacagcatat 1947961 cctggatcgt ttggtctgca tttgtttttt gaatgctgac gggtatgatt gcagatgtat 1948021 cggcatcagc aaccgctaca gtgatgtaat tgtcttgttc cttttcagga acgacaaacg 1948081 atgtctgatc caaggacgat gcagcttttg ggctgtcttc tgtctcagtt ttcgttactg 1948141 cgttctcttg ggacgcttct ttttgttgag gctgtgcctg atcaaagaaa tgaggagaaa 1948201 taatgaaggc gatataaacc gcaattgcag cggcacacgc ggggccaatc cacctgacag 1948261 cgggcttatt tttacgcttt gccatcgtca gccgcttgta aatatcctga ggcgaacgat 1948321 ggtctttaac tgccggaagt tgacttaaca actcctttat ctgttcttcg ttccattctg 1948381 acttcatcat ccattagctc ctccctcaaa agctccatat gtttccgaag tactttgagc 1948441 cctctgtgtt gggtcgtttt tactttgctt tccgagaagc gcagagcctt ggctgtttcc 1948501 tgtattgaat atccctgaat aaaccgcaag ataatcacag ctctttgatc gattgtacat 1948561 tgatcaagcg cagcataaat ttcccggaca ttttcatgtt gaaccgcaag ttcgtccggc 1948621 agcaattgct gatccctgac atcctgtgta tcccagtcaa atgtaccgag tatacgctgt 1948681 ctgattgttt gctgtttacg gaaccagtct atcgcaacat ggcgtgcgat agacaaaagc 1948741 catgtttttt cactgcttct tccttcaaac gtatgataag aatttaatac ccggatataa 1948801 acctcttgaa gaaggtcttc tgtctggttt ttatccttta ccatataaaa taaaaattgg 1948861 tacaaatctt gatgatatgt atcatataat aattgaaagg tttcttccat ttgaaacccc 1948921 tccgttcact tttttgtcgt atgaatagct tgaaaagtta cattacaact atattacgag 1948981 taactggaat ttggaaggga atttatatta acatatcctt aaattttatt aatgttggct 1949041 attaaaaaaa cacccgctca gtcagcgggt gtttcttatg gaacaagatt cttcggcaaa 1949101 ttcagactcg attttaccgt tttgtcggaa tataaaaaga aaatgttgtt cctttatcta 1949161 ttcggctgtg cacagtaatt gatccgttgt gggcttccac gatattttta acgatagcca 1949221 gccctaaccc ggttcctgct ctgccccttg tccgcgcttt atctgcctta taaaaccgct 1949281 caaagataaa tggcagatct tcttccggta tgccagaccc ggagtctttg atatcaattt 1949341 tcaatccatc cttcacagaa tggactgaaa tggagacact gccgccggct gaagtatgcc 1949401 gcagcgcgtt atcaatcaaa ttggtaaata cctgctccat cttgtcttca tcaaacataa 1949461 attcctcttc tgtgagagaa atgtcatgat ctaaagcaat atttttttct ttcgcaacac 1949521 cggaaaactt ccgaatgatc ttttctaaaa actcattcac attgattttt tcataatgta 1949581 agcctgtatg gcctgattcc attcgggcta aatcaagcaa atcattaact aaacggccca 1949641 ttcggagcga ttcgtcataa atgatttggg caatttcttt ccggtcttct tcagagcttg 1949701 caatgtcatc gacaattgct tcactgtatc cctgaagcat ggagatcggt gttctcagct 1949761 catgactgac atttgcgata aagtcctccc gcagcttatc aaggcggcgt tcttctgtca 1949821 tgtcacgcag tacggcaacc gctcctctga cgtgcgattc cgcataaagc ggcgacatca 1949881 aaagcaccca tgatctgcct tgaagcgtca tctcaatcat ttgttctttt tcagtgctga 1949941 cagcgttttg aaacagctct tttgcttcag gcggaagatt gtcgccttct ttgatattca 1950001 tgttctgttc ataataccaa gcctgaagaa aacgttcagc cggcgggttg gtcacaagaa 1950061 tcgtaccgtc aatattaatg gtaataaccc cgtcagccat actgctcaaa atgttagaaa 1950121 gctgctcttt ttcttgattg agcgcattga tatgaaagtt aagctgccgg cccatttgat 1950181 taaaagcggt cgccagttca ccgatttcat cctgagttaa aatcgggatt tttgtatcga 1950241 acttgccctt cgccaaatcc tgcgcgcctt ctctcatttt tcggagaggg tacgtgaccc 1950301 tgcttgataa aaagaatgcg aaaaatgtgg tcagcacaat cgcaattcca gcggcaagaa 1950361 aaatatagcg ggtcgtatgt tttgttgtat ctttaacggc aagcaaagac tgggataaaa 1950421 agaccatgcc tttctttccg tctttttcat acgggacacc tacaatcagg cgttcattat 1950481 ccgtgtctgt atcgctcagt cccgtccgtt tgcttacttt tttatggtct ttgagagctt 1950541 tatttaagtc tttgtcatgc tgtatttgct caaccgtaat agacgacagg cgatttttat 1950601 cattcggaga ataccagtgg ttcttctcat cctggatgat ggcaatgctt gttaagttat 1950661 cagcgagttc ccaagtgatt gaccttgcca gtgcctggtc ctcgtgattt tctaggatga 1950721 cagcaacttt attcgcaagc tgtgttaaat cattctcagc ttcttccaca tggtagtttt 1950781 caataaactc cagcaaaaga accgttaaaa tgaacaatac gatcaagacg agtgaaagga 1950841 tcgtaaacca cagcttgcct actacgcttt tccaaaattt cattcagcgc cgacctcaaa 1950901 tttataacct acaccccata cggtgacaat ttttttcgca gcttccggag ataccttgtt 1950961 cagcttctct ctcaagcgtt tgacgtgagt gtccactgtc cgtaaatcac caaaaaactc 1951021 atattgccac acttctttca gaagcttttc ccgatcatac accttgtcag gcgttttcgc 1951081 taagaaatat agaagctcat actcttttgg cgtcaggctc acttctgttc catcagctgt 1951141 tacgcggtga gcatcatggt ctattgacag atgtgaaaac acgagcacat ttttcgtcgg 1951201 tgtattggca ttgaaataag aggtttggga tgctcttctc aaaagggcct ttacacgcag 1951261 cacgacttct ctcgggctga acggcttaac aatataatca tctgttcccg cttcaaaccc 1951321 ctgcacccgg tttgcttctt ctccttttgc ggtcagcata ataatgggtg tcgctttttt 1951381 ttcacgaatt tgccggcaca cttcaattcc atcagtcccc ggcatcatca gatcaagcaa 1951441 aattaagtca taattggctt caagcccttt ggcaatggct tcatcaccat tttcagcttc 1951501 atctatagca taattttcac gttcaagata cattcttaaa aggcggcgaa ttctggcttc 1951561 gtcatcaact actaatattt ttgtttcgtt cgtttggtcc atgttttccc cctgctttcc 1951621 ttctgttact ttcattttat caaatcgtga gaaagtttga gaactgtgtc gctttcaaag 1951681 gactatgcat aagaatgaag tccggcaagc acaagattta cgaatattaa attaaacata 1951741 ataatagcaa aaccgattac ggccagccat gctgacttct caccgtgcca gcctcttgac 1951801 agtcttaaat gcaagtaagc ggcatagaac aaaaatgtga tcagcgccca tacttcctta 1951861 gggtcccagc cccaaaatct ggtccacgcg agctgagccc aaatcattgc aaagatcagc 1951921 gcgccgagtg taaagatcgg aaatccgatt gatacggccc tgtacccaac ctcatccacc 1951981 agatcaagat tgacgttttt caccagcgga tgtaatagag cgctgattct ttttctgatg 1952041 atcagacgga gagccccata caacacaaga cctgctccaa atgaccaaat gacagtgttc 1952101 acttttctgc ctgagaaaag cgcgggaaga tcaacaagcg gttccattct tccttcggtc 1952161 aaaagctctc cctgatgcgg accgacaagc gcgggcattt cgtacaccat cacgcttttt 1952221 tctttacttt tgtccaccca gttaaactcc gcttcatagc ctgcaagacg aaatgccgat 1952281 gtgattgcaa taaaggcgac ggttgtgacc aggataaaca taatcgcttc aagccagaag 1952341 gtctttttgc ttggctttgt ctggtctaca tgcttcaaaa gaaagatgac accagcgaca 1952401 aagctgatgg caagtatagc ttgcccaagc gcggccgttg ttacgtgaat atacagccag 1952461 ttactttgga gcgaaggaat taaaggcgag atatctgtcg gaaacatgct ggcgtaggca 1952521 atcagcaata aagcaattga cagcgtaaac aggcctaatg aaggcaatct atagagaaaa 1952581 taaagaatga taaacgccaa aacaagcatc atgccaaaag cggtggtgaa ttcaaacata 1952641 ttgctgacag gcgcatggcc gcttgcagcc caccttgtga tgaaatatcc taggtggcag 1952701 aaaaaaccga caatagaaag ggtgattcca atgttggccc atcggtttgg cctgcccttt 1952761 ttatctttat tcccgcgtat ggccccgccg aagattggga cagcgattaa atacacaaga 1952821 aaggccgcat aaagaaaatt tccgctcagc tctgccatga catcactccc ttttcgccta 1952881 tttctgtgtt ttgattaatt ctttttggtc caccggttca gtcagtccgg aatcagccaa 1952941 tataaatgct aaatccttct tcaggccaaa ccagttttta ttggtatgcc ctgctaccat 1953001 aactgcaccg tcctgtgagt gcagccaaat tcttcgatgc tgccagtaca taccttgaat 1953061 gacaccgatc ataaaaatgg ctccgccgac agcaagcacc cagagtgtca gatcctttct 1953121 gactgtaagt ccagtaatgt ttttcgtttc gacatggtca aatttcagct tgtatttatt 1953181 attgcctgat ccttcgatgg tttcttggat ggcgacaaag ctcttttcgc ctttcggttt 1953241 gtccggcgtt atgatattaa agacaaaagc cggattgtta gggatctttg tttttgtgct 1953301 cggctctccg tcctgattaa aatagaagtc aggcaggtag ctggcgattt ccaccttgta 1953361 accgttacca agatcataga ctgaatctgg atccagaagg ttgatcttca ggctcccaaa 1953421 ggattttttt gtttttttat caatcagctg gaacaccatt tggtcaagct gattctcttt 1953481 gtaatccacc tggtaaacgg aaaaagaatc aaaacgcagc ggctgattga cacggatgtc 1953541 ttcttctgtt actttttcca gcttcggctt ctcgccataa acaatttttc cttctctctt 1953601 gtagagtacg gcatcagttt gaaagttctt tgccactcta ccgtccccga ctctgtcaat 1953661 ggcatctgca aatacctttt tttccgtttt gctgttatag gtctctacgc tgaattgatt 1953721 gtttttcaaa taatattttc cgtctgtacc cggaattgct gcggtttcgc cttctctgac 1953781 ccaaagcgtc tcatcgacgt acatgccagg cacaaatctc agcatcgcac caatcagaaa 1953841 gatgatcaat ccaatgtggt tgacatacgg gccccagcgg gaaaagcgtc ctttttcagc 1953901 aagaatgctg ccctcttttt ctctgattct ataatgtttt ttctttaata gagtaactat 1953961 cttttctttc gattccccgt tcagtacagt aactgtttca ctgaacaagc gctgccttct 1954021 taaaaaggcc gggctccttc tgacaccttg gttttttaac gctctataca acggaatgac 1954081 ccgatcaagg ctgcaaatca cgagtgaaat gccgatcgag gcaatgagca gcaaatacca 1954141 ccaagaacca tataaatgat gaaacccgag caaataataa agctggccaa acgtgccgta 1954201 ctgctccttg taataagtat cagcctgtgc gcccggaggc agataggctt cctggggaaa 1954261 aatggtgccg aacgctgatg cggcaagggt tatgacgata agccatattc ccaccttaac 1954321 cgaggaaaag aaattccaaa ttttgtcgat gatcgttttg ttataggttt gcgaacgtct 1954381 tgcgcttccg tcatatctca tatcagcgag cggaggttga gtttcctgaa gagctcttcc 1954441 gcacgattcg cataaaacgg ttccgaccgg gtttatatgt ccgcattcac atttgacttg 1954501 cttcatcccg aagtctctcc gggttttatg agattcatat aatcgtgtat catgctttct 1954561 gtcatagtgc cggtcaccac cttgacaact tttccttccg gattgatcaa aaaggttgtc 1954621 ggaagcggag atacgtcata ggcatcaagc acttggcgat ctgtatccag aacaaccggg 1954681 aaattgactc cgtaggattt cataaaatta tgtactgcta tctttgactc cccaacattt 1954741 acagcgacaa tttcaacacc ttggctttta aaatgcttat attggtttgc catataagga 1954801 aactcttttt tgcacggttc acaccatgta ccccagaaat tcaaaaaaac acctttccct 1954861 tttaagtcac tgagctcgat acgtttccca ttcgtatcct ctaggacaaa attcggtgcg 1954921 tcggaccctt cggatatact ctctttgccg gcaaatacag cgttgtaaat ggtatagccg 1954981 agtgcgcaga ttaaaacgag aaggatgccg gtccgaatga ataaacgcct ttttttcttc 1955041 attgtccact gcccccttcc ccctattgca gatccattca attatatcat tgcacgttca 1955101 tttcacattt cttacttttt gaaggttatg tgaaatttag aaagcgtttt taccgtgatc 1955161 cgccagtgct ctgagccttt ttacttcgtg aggcgtaagc tctctggcat cgcccgtgtg 1955221 caggcctcgc aggtttaaaa acgcgtattc ctcacgcttc agcttgatta cctcatgtcc 1955281 gatcgcttca aacatgcggc gcacttgtct gttgcgtccc tcatggatcg tcagctgaat 1955341 aatgcttgtc tgctttttct tatccaaaga cagcagcttc gctttagcag gcgctgtttt 1955401 gccttcctcc agcctaattc cgcgctccag ctttctgagc agctctttag gcgggattcc 1955461 tttcaccttc gccacgtatg ttttgtctat ttcatactta ggatgcatta gcttattggc 1955521 gaattcgccg tcattggtta aaagcaaaag accgctcgta tcatagtcca gacgcccaat 1955581 cggataaatg cgctgcggaa tatttttaaa aaagtccgtc accactttgc gtcctttatc 1955641 atcttgcgct gcggaaataa cgcctcttgg tttatataag agaaagtaaa ccggctcttc 1955701 gcgttcaacc tttaacccgt ttacctcaat ctgatcagaa ccggtgacct taacacctag 1955761 ctctgttact actttgccat tcacctttac ttttccttct ttaatcagct cttctgcctt 1955821 tctgcgcgac gcaactccgg catgagcaat cactttttgc agtctttcca tgtctttcac 1955881 ctcaagtatt atcttacttt tttcaacctt aacaaacaag ctttttcaaa ttcctatgcc 1955941 aaatctaaaa aaaacgccgt tttcaggcgc tcccaaataa taacgtaacg atgatgatag 1956001 atgcaactac gccgattaaa tctgcaagaa gtcccacctt taatgcatca cccatttttt 1956061 taatgccgac tgctccgaaa tacacagtca gtacgtaaag cgttgtatct gtagatccct 1956121 gcatgacgga agccagcctg ccgataaagg aatcgggccc gtatactgca attaaatcgg 1956181 tcgtcattcc aagtgcggcc gtaccggaga tcgggcggat cagagcaagc ggcactactt 1956241 cagcagggat gccgatagcg gagaaagccg gttttaaaag atccattata aaatcaagcg 1956301 cgcctgatga tctgaaaaca gttatagcga caagcattcc gactaaatag gggataatgg 1956361 aaaaggcaat ttctatcccc tctttcccgc cttcgacaaa cgattcatat gtcggaacct 1956421 ttttgatcgt tccataaaga agaattccgg caataatgat tggaatcatg gctaaagaca 1956481 gccagttgat gatttccatc cgctcacctt cccttctttt tgcggcggta ataaaaatac 1956541 cgatcaatga taatggcacc gattccggaa ataagcgttg ccaaaatgct tggcccgacg 1956601 atatctgtcg gcgttttgga ggaataagcc attcggacag cgatcaccgt tgtcgggatg 1956661 agtgtgatgc aggacgtatt aacagctaaa aaagtaatca tcgaccggct tgcttccgat 1956721 cggtttccgt tcagcttttt catttgttcc attgctttaa tgccaagcgg agttgctgca 1956781 tttccgaggc cgaagaaatt cgccataaga ttagataaaa tatagcccat cgccgggtga 1956841 tccggcggta tatcagggaa cagtttagat ataaaaggtc tgcacatccg gctgaaaata 1956901 tccaaaagcc ctgactgctc ggcgattttc attaagccaa gccagaaaac aagcacgctc 1956961 atcaatccaa atgagatcgt aatcgcttct ttcgcaccct taaacacggc ttcatttaca 1957021 tcttgcagag ttccgttgca catcgcaaaa acgagtccga tcacggttaa actgacccaa 1957081 attatattga ccattttgct ccgcctgccg cattcagaaa gattgattta aacgtttcaa 1957141 aaaattgttt cttcggtttt tgatgccgct cattttcata atagatcggc acttttgcga 1957201 tggttgcatc gttgaacatg atctccatgt gccctacgat gtcagggatt ttcgaggcat 1957261 ctttttccca tgcttttttc ggcttgagca gtgtggtatt aatttttaca ttttcttttt 1957321 cctcttcggt cagcaaatag gtgatatcac gtttgataaa agccttcgat tcataaaatg 1957381 tgcctttcag ctttggaata tccccttttt ttgcaattaa ataggtttga taatgctcaa 1957441 acacatagtt aaacatcttc atatggtcat cccaatcatt agggtcatta atggtgacgg 1957501 ctatcaggtc aatgccgtcc tttgaagccg tagagaccag tgtccgtttt gcaagttttg 1957561 tatagcctgt ttttcctcct gtgctgtacg gataaagcat ggtcagcagt ttgtttttgt 1957621 ttttccatac gctttccatc gtttccgctt tgtatatttt tgtgcctgaa atcttttgat 1957681 agtctttcag cttcatagca tacttagtta aaatggccat gtcataggct gttgaataat 1957741 gattttcatg gtcgtccaat ccgtgcgggt tttgaaaacg ggtgtttttc ataccaagct 1957801 gctcggcttt ttgattcatc atataaacaa acccatcgag gctcccaccg acatgctcag 1957861 caatcgcgac agcggcatcg tttcctgatc ttagcatcag gccatacaca agatctttca 1957921 gcttcacttt ttgaccttct gttaaataaa tggcggagcc ttctgttctg acagcatttg 1957981 ccgaaaccgt cactgtttga tccattttgc cggattcgat ggcgaggacg gcggtcataa 1958041 tttttgtgat gctcgcgatc cgcctttttt gatgctcatc cttggcatat aacactctgc 1958101 ctgacgcacc gtcaataatg atcgcgcttt ttgcactgac atctatagca gcatgtgctg 1958161 tattcacatt tacggttgca ataagaaaag aaatcatgat cacgaatact gcttttttga 1958221 aaatgcgcat gtttgctcac gtccttgtgg tggtttgtac aagtttatgc gcatgtccat 1958281 cagttatgaa taacaattat atttctggaa gcaaacataa aaaaactctc cctgaaaaag 1958341 ggagagtaaa cgttatctga ttggcgccat gcttgatccg gacgcttcgt aatgagccag 1958401 ctcttccctc atcttcagaa aggccgcgct caacggcaat aataattgct caagcgacgc 1958461 aggaacagca tgataaaact caattgcgct gaccccggta taagacgccc ggctattttc 1958521 acaccacgtg tcttttttcg gcataaagaa ctcttcaatg cattggtgat acacattata 1958581 aagtgttttt tccgctctgg cttcctgaaa aggctcctgc atcaggagac gacggcacgc 1958641 ttctgcgcct ccttcacaaa atactgccat tcttctcaga gtgctaagca catcacagca 1958701 gtatcctttt tcaataggca attcagcctg taaggactca agcgtcgttt gatttaggta 1958761 atcgttcacg gtattgacaa ccattgataa gaattcgcct gttttttgag tctgcgctcg 1958821 cacaatcgaa tgtcccattt cgtttggtat cttcccctca tgtatttgtc tctcacattt 1958881 tgcttctttc atgatagctt cttccttata tcttatgatg atgaaaaagc gcgattcatt 1958941 aaacttctat tttatatctt cgaaggtttg gttaaagttt tcaaaaaata aatctgcttc 1959001 ttcttgaaga acgtcttctt ccgcattttc aggcagcggc ggaagctcgt ccagcgtttt 1959061 cagaccgaat tgttcaagaa aagtcggcgt agtaccgtat aaaatggccc gccccggacc 1959121 atcggcacgc cctacttcac acaatagcgc cttcgcgaca agactgtgta aaatccgctc 1959181 tgattttact cctctgattt cttcaatttc tgctctcgta attggctgtt tgtatgaaac 1959241 aatggccagt acttctaaag atgcttgaga aaggcccttt gacggcactt caatcagttt 1959301 tttcaagtaa ggcgcaaagt cttttttggt agagagcatg tacgtatctg catactcaat 1959361 aagttcaatc cctcgtgtat ctccgcggta ttcgtccgcc acatccgcca tgatcgtgtt 1959421 cagttcaggc tcttcgattt caagcactgt taacagctgc ttttttgtaa gcccttcatc 1959481 gcctgccgca taaagaaggg cttccacaat agctttccaa ttcacgatat caagccccat 1959541 gaatggattc actccccgta atgtaaatat ctgaaaaatt gtgctcctgt tcaatgagga 1959601 ccagctgatt tttcatcagc tcaagaacag ctagaaaggt cactactaaa tgttcttttt 1959661 gctcatatgg aaacagatcc ataaagttaa ttctcgttcc tctagatttc aagctgtgca 1959721 cgatttcgtt cattctggct tcgattggta tgtcctgtct tgtaattgtt gtttccatcg 1959781 gcctgtttat ttttttgcgt ttcagcactt tttgaaaagc tccgatcata tcatagaccg 1959841 tgacagagag cttttgctca gactgtttta cttcttttgc atattcactc aaatcactcg 1959901 gcggtttcgt gaacgatttt tgtctttctt cttcccgttc ttttaaatcc ttcgccgcat 1959961 ctttatattt tcggtactca atcagctttt caatcagttc ctcccgcgga tcttcttctt 1960021 caagtaattc atcttcaaaa agctcctcct cttgcttcgg gagcagcatt ctgcttttaa 1960081 tgctgagcag cgtggcagcc ataaccaaat actcgctggc aatgtcgagc tcaagcacgc 1960141 gcatcgtatg tacatataat aaatattgtt cagtgatctt cgccacaggt atatcatata 1960201 tgtcaatttc aagacgattg attaaatgaa gcagcaggtc caatgggccc tcaaacgtat 1960261 caattttcac ttgatattct tccatcatct caccattttc aagtatcact ctcattgccg 1960321 gaaaaactgg ctaccctata gtataagcca ccaaaaagct ctcgtccaat actatttcat 1960381 atcctgtttt gaaggagttt gtacagaata ttcaaaacac aagaggtgtt tgctcggagc 1960441 gcagaagcgg gagaaaaagc ctttgcttct ggttttcctt tctaagaagc actagaggcc 1960501 gggcgttctt ttttcctttt atcccttcta tggtacacta aaagcacatt aaaggaggaa 1960561 gcaccttgta tccgaaagct tatatagatt atctcgttga gtttcatgcg acacgggatt 1960621 attttgaatg ccatgaaata ttagaagaat attggaagga agatccgcca aagaaacgaa 1960681 aacgctattg ggtgggcttt attcagcttg cagtggcttt atatcatcac agaaggcaga 1960741 atacagccgg ggcaaaaaga ctgatggcga acagcatccg gattcttcaa gcagaacacc 1960801 gggcagtcga agacttaggg cttgatcatg gccgtttgct cgaacttatg caatcggttt 1960861 acgaacaaat cgaaaccgtc tctgcctata aaagcattat actgccaatc aaagatgaga 1960921 aactggagga agcatgcagg atcgaatgca ggaaaaaaaa gtatacatgg gggcagccca 1960981 gtgcactcag caacatattt cttatcgaca aacaccgttt gcgggatcgg actgacgtca 1961041 tccgtgaacg tgaaaaagaa atagaacgca gaaaaaaaag cagagactga tcacagcctc 1961101 tgcttaatta ttgtatgaaa tgtcttgatc ctgctgacct tgacaacgtt cgaaaaagct 1961161 ctgcgttaat tcatttggaa ccagtacttg cgttttgaat aaatgcttta aagcatccat 1961221 catctgtttt ccgattcctt gatggcgatg agaaggattc acactgatat gccggatctc 1961281 aacctcagaa tccttttttt cgactccgat tgctccgacg atatcctcgt cctctttcca 1961341 aagaaagagc tggcggtctg tatccgtttc gtagtcctta attgtctgct gaagctgctt 1961401 aaggtctttt tcattcggca taaacgaaag aagccccatc gcaatctttt caaacgattt 1961461 tttataacga attaacataa aaacccctct atatccaaaa tgtccagtct gctattaacg 1961521 gatacgaata ggtgatccgt tttctcacat tatatcattt tcgccatatt tttaaactgt 1961581 tttcagcaaa ttattcaaat gagcggttta aatttgccat ttcaatggca gaaacagcac 1961641 aatctacacc tttgttgccc gcttttgtgc cggcacgctc gatagcctgt tcgatgtttt 1961701 cagttgttac aattccaaag atgacaggta caccagtagt gtttgctgct tgcgcgatgc 1961761 cttttgcagc ttcattgcag acataatcgt aatgtgtcgt tgcgcctctg atgacagtgc 1961821 ccaatgtgat aatagcatca tatttttttg tttccgccat ttttttcgca gcaaacggta 1961881 tttcaaatgc gcctggaacc caagccacat caatgtcatt tgtgtctacg ccatgtctga 1961941 gcagcgcatc ttctgctccg ctcagcagct tgctcgtaat aaaatcatta aatcttccta 1962001 ctacgattcc gattttaaga cctgtaccaa ctaaatttcc ttgtatgata ttcatatgat 1962061 tcccatcctt ttttgtgata tttgtgatta gaaatgaagt aaatgaccta gcttgttcat 1962121 tttggtttgc aaatattttt tattgtgttc tttcgcctcc atttgaagcg gcactctttc 1962181 tgaaatactg agtccgtagc cttcaaggcc tgcgattttt cgcggattat tcgtcaaaag 1962241 cttcatattc cggacaccga ggtcgcgtaa aatttgtgct ccgatgccat agttgcgaag 1962301 atccggcaag aatccaagcg cctcattggc ttctacggtg tcatagcctt gttcctgaag 1962361 cttataagct tttaatttat tgattaaacc gatgcctcgt ccttcttggc gcaagtacag 1962421 gagcactcca cggccttctg cggcaatttg gttcagcgcg gcgtgcagct gcggtccgca 1962481 atcacagcga tgagagccaa acacgtcacc tgtgagacat tctgaatgca cccggaccaa 1962541 taccggttct tctccgaacg gcacatctcc catcacaaat gcgacatgct cttttccatc 1962601 tacctcattt gtgtatccat aaaccttaaa tgtcccaaaa tcagtaggca gcgtaatgtc 1962661 aacttcacgc tcgacaagtg ttgtcagatt gtaacggtat tgaatcaaat ccttaatggt 1962721 gatcattttt aattgatgct ttttcgcaat ttcaatgagc tcaggcactc tcgccatcgt 1962781 tccgtcttca ttcataattt cacaaatgac gccggctcct ggagatccgc aagcttcagc 1962841 aagatcaaca gcagcttctg tatggcccgc tcttttcagg acacctcctt ttttcgcaat 1962901 cagtggaaaa atgtgccccg gacgctgaaa atcagatggc acggatttgc tgtccagcaa 1962961 tgcttgaacg gtaaaagatc tttcttgagc gctgatacct gtcttcgttt cacgatggtc 1963021 tatgcttacg gtaaatgcag tgtggtgaga gtctgtatta tgctcaacca tagggtgaag 1963081 atcaagcctg tctgcgattt cctcactgag cggcgtgcag atcagtcctc tcccatgtgt 1963141 cgccataaag ttaatgactt ccggcgttgc atgctcggca agagccacaa agtctccttc 1963201 attttctctg tcttcatcat ctacaacgat gatgacttcg ccttttttta aagcgtccag 1963261 tgcttcttct atcggatgaa acatgcaaat cttcctctct aaaagccgtt ttcgcttaag 1963321 aaggcttttg taatggtttg ttgggtctta ttttcattgg ctttatgcaa aaatcgatac 1963381 atatattttc cgatcatatc gcattcgata ttcactttag agccgatcgt tttttctgaa 1963441 aagatcgttt cgctgatcgt atgcggtatt aaggagatcg tcactgtgtc ttctgtcagg 1963501 ccgaatatgg ttaagctcac gccatccaca gtaattgatc cctttaaaac caatgttttt 1963561 gttaatgacg ggtccatttt taaatcatag taaactgcgt tgcttttctc ttcaattcgt 1963621 gtgatttccg cagttccgtc gacatggcct gagacgaaat ggcctccgaa acggccgttt 1963681 gccgccatcg ctctttccag atttactttg cttccttttg ttaaatcatt cagtgacgta 1963741 gctttgactg tttcaggcat aacatccact gtgaattgat tttttgtaaa atcagtgaca 1963801 gtcagacaaa tgccgttcac tgcaatgctg tcgccaagat gaacatcctc taaaatcttt 1963861 gagcatttaa tagttaaggc cattgcatgc cctgcttttt tcatggattc gattgtgcct 1963921 gtttcttcga taattcctgt aaacatggtc accatcctat tcctttgtcg gttttgccgt 1963981 cagtttgata tcacggccga tttgggttat atcagtgaat tgtaataagg ggacatcttt 1964041 cattgattga aaaccttcac cggagattaa gctgggagca tgcgttcctc cgattagttt 1964101 aggggcaaaa tagaagatga tttcttgaaa acagccttct ttgacaaagc ttccgtgaac 1964161 agctgaaccg ccttccacat acaccgacat gatgccttct tccgctagga tcttcaaaac 1964221 atcaggaatt tgaatgcgct cggtttcaag tgtaaatatg ttcactccga aagctgaaag 1964281 ccgttttttc ttttcctcgt ctgcgcgtgc cgtcgtaaaa atccatgtcg gcgctatttg 1964341 atcgcaaatc actttagcgt cctcaggaat cgagagtacg gtatcaagta tgacccgaac 1964401 cggctgtttt gttacattcg gcagtctgca ggttaagctc ggattgtcgg ctttcactgt 1964461 gccaactccg actaaaatgc tttggtgtgt tttcctgtat tgctgagcat cctgtcttgc 1964521 agcctctgac gtgatccatt tgctgtcacc cgtgctggta gctatcttgc cgtcaaggct 1964581 ggcagccgct tttagcgtga cgtacggaag gcctgtcctc ataaagtgca gaaatttttc 1964641 attcagcctc tccgcctggt ctgccaggat gccttccctt acctcaatgc cagcttcttt 1964701 catcatgctg atccctcttc cagccacaag cggattagga tctctcatcg ccacgaacac 1964761 tcttttgata ccagagttga taatcaattc tgcacatggc ggtgtttttc cgtaatggct 1964821 gcacggttcg agtgtaacgt aaatgtcggc accctctgca tgtgctccag ccatatggat 1964881 ggcatgaact tctgcatgag cttcaccata ttttaaatgg gcgcccattc cgacaatttg 1964941 tccgtccttt acgacaacag cgccgacgag cggattggat tcggtctgtc cttcgccctg 1965001 cttcgcaaga tctaaggcca gcttcatata atactcttcc atttgtttcc ctcccctctt 1965061 ttgttattta ccgtcaaaaa agccccgaat ttataaaaaa ttcggggctt taggtatttt 1965121 acgcaatagg aaataacact atgcattttt aaacattttg catagcggct catcatcctt 1965181 ctcccatcca gactttcact gtcggcttca gcttaaactg aatccaccgc gtgcttatgc 1965241 acacgggtca cgggctctaa agcaaatgtg ctttactacc gccggtcggg atttccaccc 1965301 tgccccgaag gatacaatct ttattcattt gtccttattg gttattatag cgatcctttt 1965361 taaagtacgc aatgaaataa acttacaatt tgagaaaaac aaaacatcac ccttcgatcc 1965421 gaaaggtgat gttttttaat cattcacttt tgcaaccttg attaatccgt cgatccgctt 1965481 tgatttgctg aagtaagcct taatcttgtc accttctttt atatcagata aatcctgatt 1965541 taattttttt ccgttgaaga tgattttcgt tccgttttct gctactccat gatactctga 1965601 gccgtcaatt ttcgtcactt tatattcctg gatggtgtat tcctcttctt ccgaggacaa 1965661 ggtttgtcca attgctgtcg gaacatcctt cagctcaata tcatttatgt acatataacc 1965721 gcctgcaagt aaaagcaaaa gcactaacag aatggtaatc ttggttttta ttcttcccat 1965781 ttctaaacct ccagccaata tgaatctatt cattcatatg agttattcct ttttttcatg 1965841 aataaaaaac cgtaaattct cgtaaattat taatataacg atgcataacg ggaatatgtt 1965901 tcacatttct gcaaaaattt cttttctata gatatacgaa tttatgttct gtttttaggg 1965961 gatgaccgta aaaaagatat aaaaaaagca gccccaatgg gaagctgctt gatcctaatt 1966021 tgttttgcgc atttcgttaa acgggtagaa aacaaacttt gacgtacccg caatttgttt 1966081 tttcgtgaag aggccaaggc cgttacggct gtccatggaa ttgcgacgat tgtcacccat 1966141 cacaaaatac ttgttatcag gcactttaac cgggccgaaa tcatcggtca aatggtcaaa 1966201 accgtcctgt ttcgctctct ttttattagc cgccaaataa ggttcgtcca cctttttccc 1966261 gttgatatag agctggtcat ttttcatctc aaccgtatcg ccgggaaggc cgataatacg 1966321 tttgacatag tgaacatcat ctccgtttaa cacgacgatg tctcctctat caaactcgcc 1966381 gatgtatttg actgtcatat taacaaaaac cctttcacgg ttgtgaagtg taggatacat 1966441 agagtcacca tcaacgacat acggcgcaaa aataaagttg cggatgagca aagcaagaac 1966501 gacagcaatc acaattgctt ttgcccattc taatattgac tttttcttcg aaacattttc 1966561 tgatttcaac tgatttcctc caataaacaa cggtcttcaa tttatgttat cacgaatcga 1966621 aaaaaaatcc cattaggacc attgaagtga ttttacaaac tgttaatctt catcttctac 1966681 ccacatcatg cctatttttt cttgtcgatc ataactaggc ctgaaaatat tgaaagaaat 1966741 gaatcgcata attcagaagc gatggactca gaagaaagag agttctcata tgcaaaatct 1966801 ttagatcgta tataaagcat gaggttacgg gcagtttgtt catttactgc attccattga 1966861 tctcccagtc catgataccc atggcacttg acaaaacaat taacgtcatg aaggttactg 1966921 gaatgtttgc ggcaacctat ttcacaggtg ataaccgcac cccgtttttt gctttcataa 1966981 tatgtttaaa atcattcaag ctcgaaaaca tggatcagcc tccaaaaaat aaatccaata 1967041 tattcccggc agttgaagac tctttattat aaaactctga atatccgcag ttcttacagt 1967101 aaaccactag aaatcggtta tgctgcacgt caaacagctt tgataatccc gtgccggttg 1967161 tagctatttc tttttgtccg gcttcagtac taccgcattt tatacagcct ttgttgttca 1967221 tatcgcgatc tccttttcat tacatcacgt ttgtttgatt tattttacta caaaatatca 1967281 atcccaatga cccgtactac tttaaagttt acttaatttt gattacatac taattgggtt 1967341 cgtttctcag cttggtaaat cttctggaga aacggaaaag ctccatgacc aaaacattca 1967401 aactcagcca aacaccgccg aaggcgtaac ccgcagcaac atcactcgga tactgctcat 1967461 aaagtacaca cggctcagcc cgatgaggaa taaaacgata ataaacaaaa aaatgcaaca 1967521 gtttgcagac gcgtcttgtg agaatgacga acaaaaagat aagcacaaaa accaaaaatg 1967581 acaaatgccg ttaaagtctg ttcgctcggg aatggatata atacatgact ttccaaagga 1967641 gcgtgaacag gatgaaggga atgaaagagc cgtctgattc cctcttcata aagctcccca 1967701 ccaatgacta ggaaaaataa gaaagagagt tcgattttcc gatcttgccc tctgaatacc 1967761 gtccaaaaaa aagttagaac aataacggct aacagaacac ctctcgacgc aaaagctttc 1967821 tgaattgcag ctgggcccag tctatacccg atccaatacg acatgctcac tcccacagct 1967881 ccccaatccg gccgctaaca tgcttagcac ccagtttaac ttttcttgaa acacgagaac 1967941 accggcaaac tctcccggtc caagtaaagc tagaagctct aacatcaaga caataaacaa 1968001 gacggcatat ccgtactgtt cgagcaaccc cgtcaaaact tgcatgtgat tctccttaaa 1968061 cttttttgtt cttttatcat tcccaatcca ctttttgtat aatcagcaca attttatctt 1968121 cagtcgtcca acaacattgt ctatggcggg atcttctctc atacattctt ttttgacata 1968181 ggaggagcaa tagcatgaaa tgggaggaaa caaaagatac gcagggagtt tgccaaaatt 1968241 ttgggcagtt cgttctgcca ccgagtcagg tgtttgtttg cccacctcat cccttgtcaa 1968301 ttccccattt ttcccgtttg aggttcgaaa tggtaaagta tttcacttag tttcttacat 1968361 gaagaggtaa attctttgct caccgaacta ggatagcggc gtatggcgat ttctacattg 1968421 cataaccact ggttatttag tgagccgtga gcaatgtata tgcactttga gtcagcacag 1968481 gatgatccta ttacattcgc cagaaaagca gctgccgcat tcagagtagt taaaagaata 1968541 gacagatatc tgggcttccg gaagctttaa aggaggctct tttttcgagc atttttataa 1968601 atcaataaaa acaggcatct cctaaatatt tttgccgata agtttacgct aatcaactct 1968661 agcactaata catataaaaa atagaatgat atgaaaggag acttgatagt atgattgatt 1968721 atcctattaa tataaacaac gtttccggga acagtgtaat taacgtaggc ggcgctttta 1968781 tgatcaggcc tttaactttg tccaaatctg tgtttggctc cggaggttta aacacaggaa 1968841 ttgtctttga aaataacttt gtaagcaaag ctaaaatgat taatcatcaa tttactgatc 1968901 aaaacgtcac caaaactttt taatgtattc aatacacggg ggtcactaac taaacacctg 1968961 gttttgccaa ccgccatcag cattcggcgg ttttttattg aacatttttg gccaataaaa 1969021 aaagcttcct ctctaagagg aagccttttg cctgccgatt agccttctac acgaacttct 1969081 ttcatgacat cgccattaga catgtttttc gcgaattcta atccgcttgt tactttacca 1969141 aatacagtgt gaacaccgtt caaatgaggc tgtggctcat gaacgatgaa aaattggctg 1969201 ccgccagtgt cttttccggc atgtgccata gaaagtgcgc ccgcctcatg tgtatgcggg 1969261 ttgccttctg tttcacattt gattgtgtat cccggaccgc ctgtaccagt tccgtgcggg 1969321 catccgcctt ggctgacgaa gccagggatc actcggtgga atgtaagccc gtcataaaag 1969381 ccttcgttcg caagcttttc aaagtttgca acagttccag gtgcagcttc aggataaagt 1969441 tcaaattcaa ttttgttccc gtcttctaat aaaaagtaac ctgttttcaa ttgtatgcct 1969501 actttcttta ttttaatttt caaaggagat tatgtatagg ttatagcctg tctctccttg 1969561 tcgcggctat tataccacac ctttcggggg aaaacgaatc tcccgagctt tactaaaaaa 1969621 taaaaatgaa acctgaatct ctttatctcc gtctaaccta acggaactgt atttttcatg 1969681 attcaggtcc tcacaaagca gcactatcca gctgcttgtg aaattgaagg aggtcaaact 1969741 gctttgaaga aaatttggat tggaatgctg gcagcggccg ttttgctgct gatggttccg 1969801 aaggtcagtc tcgcggatgc cgcagttgga gatgtcattg taacactggg tgctgatttg 1969861 tcagaatctg acaaacaaaa agtgcttgat gaaatgaatg tccctgataa tgccacaacg 1969921 gtaaccgtga ccaataagga agaacatgaa tatttaggaa aatatatatc gaacgcgcaa 1969981 atcggatcga gagcgatttc ttcatcgtca atcaccattg ccaaaaaagg ctccggattg 1970041 aatgttgaga cccataatat cagcggcatc acagatgaaa tgtacctgaa tgcactgatg 1970101 acagccggtg ttaaagatgc gaaggtgtat gttacagcac cgtttgaagt atccgggact 1970161 gccgctttaa ctggattgat taaggcgtat gaagtttctt ctgacgaagc gatctcggag 1970221 gatgttaagc aggtcgccaa ccaagagctt gtcacgacat cagagcttgg agacaaaatc 1970281 ggtaacgaaa atgcggcagc cctgattgca aaaatcaaag aagagtttgc taaaaacggg 1970341 gtgcctgata ataaagctga catcgaaaaa caagtggatg acgcagcttc tgatttaaac 1970401 gtcacactta cagacagcca aaagaatcag cttgtctccc tattcaataa gatgaaaaac 1970461 gctgacattg actggggaca ggtcagtgac cagctagata aagcgaaaga taagattacg 1970521 aaattcatag aatcagatga aggcaaaaac ttcatccaga aagtcattga tttcttcgta 1970581 tctatctgga atgcgattgt atctatattc aaataagaaa agcgccgaaa aatcggcgct 1970641 ttcttttatt gctttacacc cgttttaaat ggcagatcaa gttttacaat atcttcgtat 1970701 gtttctcgct tcacgactaa atgagcctca ccgttttcga caaatacaac ggcgggtctc 1970761 ggaatacggt tataattgtt ggccatgctg tatccataag cgcctgtaca aaaaacggca 1970821 agaagatcgc cttcttttac ttccggcagg tcaatatccc aaatcagcat atctccgctt 1970881 tcacagcact ttccggcaat tgataccgtt ttgtcatgcg cttctccgat cctgttggct 1970941 gccgcagctt catatttagc ttggtaaagc gcaggacgaa tattgtcgtt catgcctccg 1971001 tctacagcca catattggcg gacacccggc acttcttttt gagagccaac cgtataaaga 1971061 gttgtgcctg cgtctcccac gagagaacgg cccggttcga tccaaatttc cggaatgtca 1971121 aaaccgtaac gggaagcatt ttctttcaca gcttcgataa ttttttcaac gtattcagtg 1971181 gcatgaagcg gttcatcatc ttccgtataa cgaatgccga aacctcctcc aagattcagc 1971241 accttggata caaatgaata tgaatctctc cattcgtcta gttttttgaa gattttttcc 1971301 gctgctaaca caaaaccggc cgtatcaaag atttgcgagc cgatatggca atggacaccc 1971361 agcagctgaa tgtgttccga ttgtaatact tgttcaatgg cccgttcagt ttgtccgtta 1971421 tgaagatcga aaccaaactt tgaatcttcc tggcccgttg taatgtagtc atgcgtatgc 1971481 gcttctactc cgggcgtgat ccgaagaaga acatcgatgg agtgacccgt ttctttacat 1971541 aggtcttcaa gaagcgcgat ttcatagaaa ttatccacca caatgcagcc gatgcggtgc 1971601 tcaagcgcca tccgcagttc ttccctgctc ttattgtttc catgaaagtg gatgcgttct 1971661 gccggaaagc ctgctgcaac agccgtatat agctctcctc cggatacgac atctaaagaa 1971721 agtccctctt cctcagcgag ctgaatcatt gcgactgatg agaatgcttt gctcgcatat 1971781 gccacctgtg ctttcagccc tgcagaaata aacgcctgct taaagctttt agcacgctca 1971841 cgtattaaag ccacatcata tacgtaaaga ggtgtaccat atttctccgc taaatagaga 1971901 gcatccacac ctccgatttc taaatgacca tgttgatttt gtctgcttgt gccgtgtaag 1971961 aacaatgtca ttccctcttt ctccgcttat ggatgaaagg acagttttat ggactgtccc 1972021 ttcataatta agacatacat tatcatactc ttcagtcagt ttcaatgcga ttatgaattg 1972081 gtaggctgcc ttaagcgatt tttggggtga acgatgctgg gtcttacttt tgcgccaggt 1972141 ttcgctgtgc ggacaagaac ctgccacagc gcctttccgt taaagggaat cagcggccat 1972201 aagtacggtg tctgaaggga tttgatgctt gccatggcaa taattagcac tgtaaatccg 1972261 atgacgagcc cttttatatg aaataaagca acgagtatca tgaggacaag acggctcatt 1972321 ttgtttgcca agcttaattc ataactaggc gtcgtaaagg ttccaatcgc cgcaagtgag 1972381 acgtacagaa tcacctcagg agaaaaaagg ccgacctcaa tcgcaatctg cccgatcaga 1972441 acagcggcaa ttaaacccat tgctgtcgat aaagccgtcg gtgtgtgaat ggcagccatt 1972501 ctgagaaact cgattcctaa gtcagctaaa aatatctgca ggatgatcgg gatatgcgta 1972561 tctttattta aaccgataaa tttcatgttg tccgggagca gatcaggctg aagcacaaag 1972621 agaaaccaga tcggaagaaa taaagtagaa gcaagaatac cgaaaaatct tacccgagct 1972681 cgtggtcatt cggcataatt acttaaattt tgtccagtct cccatcgtcc gctttaagaa 1972741 tgtgataaac ccggctttct tcatatcttc ttttgcagca acaggacttt cagcgagtac 1972801 ttctccatcc tttttcagaa caagagtgcc aagctcttgg cctttttgaa tcggagcact 1972861 aatattgtcc ttcatcttga tttctttttt cacatcgttc atatcctcgc cttttttcgt 1972921 caatattgaa atcggctcag atgtagtgag ttcgataaat ttttgtttcc cttttttgac 1972981 ctttactttt gctactgttt gatttcgttt atataaagga tgcgtttcat attggctaaa 1973041 ggcgaagtca agcatttttg tcacttgcgc gtttctttct ttaggcgtgc tcgctccgaa 1973101 tacaaccgct atggcccgca tgtttccttt tttagccgaa gcagtcagac aatatttcgc 1973161 ttcgcctgta tagcctgttt ttacgccgtc tacaccagga taaaatttga taaggcgatt 1973221 tgtatttaca agccaaaact ttttatctgt attttcacgc agataatctt catacgtgcc 1973281 ggtaaacttc gtaattgatt cgtatttcaa taattcctta gccatgattg ccatgtcata 1973341 agcagagctg tagtgtcctt cctcggtcag tcctgttggg tttttaaagg atgtattttt 1973401 caatcccagc tcttttgctt ttttattcat tttcttcaca aattcttctt cagagccgga 1973461 aataaattca gccatggcga cggaagcgtc atttcccgaa gcgattgcga tgcctttcag 1973521 catttctttg acagtcattt cttcgccggg ctcaaggaat atctgtgagc cgcccattga 1973581 cgccgcatgc tcgcttgtac ggaccttatc actcattttg attttgcctt tatctaaagc 1973641 ttccataatc aaaagcatcg tcataatttt cgtcatgctt gcaggcgcca gtctctcatt 1973701 gctgttcttg ttgtaaagca cttttcccgt gtcacgttct atcagcaccg cagacttcgc 1973761 ttcatgagca agctccgatg tacgttttcc gtcttgtttt gcaaatgcag acggtgcaaa 1973821 tgtaagcagc attataccaa tcaacaaagt ggataaaaga cgtttcatct caaaagccct 1973881 ccatttcata atccttttta ttttttccaa gcgtgatggt tttatacgcc actgatggaa 1973941 aatgtttcga attttgggca taaaaaaaga cagctgtgtg atatcagaca cagctgtctt 1974001 ttggtcctgc attgattcat atttattcgt actgagcgac gatcgcttta acaagcttta 1974061 agaatccagc ttttactttt tcggtcactt ccataacttc atcgtgactt aaaggctgat 1974121 ccagaattcc ggctgccgcg ttagagatgc aggaaatgcc aagaacccgc attcccgcat 1974181 gattcgctac aatgacttcc ggaacagtag acatgccgac tgcatcagag cccatcgttc 1974241 ttaagaaacg gacttctgcc ggtgtttcgt aagaaggtcc tgtcacagca gtgtacacgc 1974301 ctttttgaat tgggatatta aggtctttcg caatcttttc agccaggctg gacagatctt 1974361 tgtcataggc tgaagacata tctggaaatc tggcgccgaa atctgcttcg tttggcccga 1974421 ttaacgggtt tgttcccata aagttgatat gatcggtaat aatcattaaa tctcccgcac 1974481 ggaattcagt gttgacaccg cctgcggcat ttgtcacgat caacgcttcc acaccgagcg 1974541 ctttcatcac gcgtacaggg aatgtgactt tctccattga gtagccttca taaaaatgaa 1974601 agcggccctg cattgcaatg acggaaactc cttcaagagt gccaagcaca agctgtccgg 1974661 catgcccttc aacagtagat accgggaatt caggtatatc ttcatatttc agcttgaccg 1974721 gattttcgat ttcgtccgcc aaaatgccaa gacctgagcc taaaataagg ccgatctttg 1974781 gagattccgg caggttttgt ttaataaaag cggctgcgcg ttcaattctg tccttcaaga 1974841 aacagtcccc ctattgtaat aaagataaaa agcttttccc gtatttcggt ttatttgttt 1974901 ggaaattatc agcgatcgtt gcgccaatat cggcaaatgt atctgcaagc ggcagcattt 1974961 gcgctttctt atgttttttg ctgtaagcga gaatcggcac atactcgcgt gtatggtcag 1975021 tcccatgatg aatcggatca ttgccgtggt cggctgtaat aattaacaga tcgtcttctc 1975081 tcattttttc aaacacttcc ggaagccgcg catcaaattc ttcaagcgcg cgtccgtagc 1975141 cttcagggtc acggcggtgt ccgaataacg cgtcaaaatc aacaaggttc gcaaagctca 1975201 gacccgtaaa atcttctccc agcgtatcga tcaccttgtc cattccgtcc atattagaaa 1975261 ccgttctgcg tgaagaagta atgccttctc cgtcgtaaat atcagagatt ttaccgattg 1975321 aaatcacatc taagccgcag tctttcaatt cattcatgac agtgcggtca aacggcttca 1975381 gcgcataatc atggcggttt ggcgtccgtt tgaattgacc cggctctccg acgaacggcc 1975441 gtgcaataat gcggccaacc atatatttcg gatcaagcgt cagctctctc gccgtttcgc 1975501 aaatgcgata cagctcctca agcggcacaa cctcttcgtg agcggcaatt tgcagaacag 1975561 agtcagcaga cgtgtaaaca attaaagccc ctgtctccat gtgctcctgg ccaagctcat 1975621 ccaaaatcgc tgtgccggaa gccggcttgt ttccaataat tttgcggcca gatctctttt 1975681 ccagctcttg aagcaattca tcaggaaagc cttccgggaa cactttaaac ggtttatcaa 1975741 tgtataaacc cataatctcc caatggccgg tcatcgtatc tttgccgttt gacgcttctt 1975801 gcatttttcc ataataggca agcggatgtt ctgttttttc tacacctttg atatcttcga 1975861 taagaccaag gccgagcttt gccatattcg gcatatgtaa tccgttcata tgctcggcaa 1975921 tatgaccgag cgtatgagcg ccttcgtcat taaagtcagc ggcatccggc gcttcgccga 1975981 ttccgactga gtccatcaca attaaaaaca cacgattata tttgtatgca ggcatcttga 1976041 aagcctcctt tttttctata cgtctattgt atcgctaaga ggtctgacaa ctcaagtata 1976101 aaccgttttc attcccgttg acaatgtatt tggaaataat gagaaacttc aatattttct 1976161 gtcgctctaa acaaaaaagc cgcagccacc tgcggctatg ctcgcggatg aaactgcttg 1976221 tacacatcct tcagccttgt tttcgtcaca tgcgtataaa tttgcgtcgt ggatatatcc 1976281 gcatgaccga gcatttcctg caccgctctt aaatctgccc cgttctcaag cagatgcgtc 1976341 gcaaaggaat gcctgagtgt atgcggagtc agctctttct taatgccggc ttccaatgcg 1976401 atttttttca ggttcttcca aaatccctgg cggctgatct gtttgccgtg atgatttaaa 1976461 aagagggcgt cagatacatt attttttaac agttttcccc tggcttttgt catatattcc 1976521 tcaatggcgg aagcagcggc ttcaccgatt ggcacaatcc gttcttttct tcctttgccg 1976581 aagcatcgga taaaccccat agataaatga acatcagccg ttttcaattc aatcatttca 1976641 ctgactcgta tgcctgtcgc ataaagcagc tccagcattg ctttatcccg atatccgaaa 1976701 gggctcgtca gcttaggcgt gtccaataac cgctcgactt cattgagcgc gagcaccttc 1976761 ggaagcgccc gttccgtctt ttgtgtttcg atatgaacgg aagggtcctt atccgttact 1976821 ttttccctga gcagaaattg atgaaaagag cgaatggatg ccaaatgccg cgccgatgtc 1976881 ttgccggatt tccccgagtc cttcaaatgc tttaagtatt ggataatatg tatgcgggta 1976941 acgtgattcc aatctgtaac atgaagggtt tctgttaagt agagagaata gcttttcaag 1977001 tcacgttcat aggatacgat cgtattttga gagagccctc tctctaccat aacgtagtgg 1977061 atgaaatcct ttatttgatc tttcactctt gatctactcc ccgttttggt aaaaaaagat 1977121 caaccggtcg aaccatccgc ctttttcatc ctgatccatt tcaacaactt ttacagcgga 1977181 gccttccggt ttatcatacc gatgatagtt ttcatactct tgattcaccc atatcatagc 1977241 ataatagaac aaagcggtaa aaccggtaaa caggatgaaa actttcaatg catcgacagc 1977301 tgttttcagg aatcttccca tgtcctaatc gatcctttcc ctatggttcc agttatataa 1977361 accatatgcc aaatcagaaa ggttttatac atagaaacag caaaaaaccc tttccccatg 1977421 agaaaaggtt cgcgctcggc accgtctatt cagtttcttt tccgttacag cggtggcaaa 1977481 tgccgtgaaa cgtcaatcta tgatctttaa tcttaaattt ccaatcacgt tcaatgattt 1977541 cttccacgtc ttcaagcaaa tcttcttcaa tttcatcaac ggctccgcac tccatgcaca 1977601 ccaagtggtg atgaaagtga gctgcgccct ctttccgaag gtcgtaacgg gacacaccgt 1977661 ctccaaagtt aattttatct acgactttta attcagttaa taattcaagc gtacggtata 1977721 ctgtagcgag accgatctca ggagatttct cttttacgag gaggtataca tcttctgcgc 1977781 ttaaatggtc ttcttcgttt tcaagcagca ctcttactgt cgcttcacgc tgtggcgtaa 1977841 gtttatagct ggatgagtgc agttgtttct taatacgatc aatacggttt tccatgtctt 1977901 tccctcctac gccgcattcc atgactcatt ataacaaaat acgcgcagag ttccaactat 1977961 aattattata aactgataaa taaaatggtt ttcttttaat aatgatttta aaaaagtcta 1978021 gatgtaagct tttccattaa aacaggagat aagtatgctt caaagagaga tgaaatcagc 1978081 gctaaaaaca gaatgaccag cagcacaaag gcataccgcc cgaaccattg aatcggcgcg 1978141 tcatgcaggc ttcgtttcac gaacagctgt ctgattaact ttaaagaaaa cgcaattgca 1978201 catgtgccca taatgagata agccggaatc agcagcacat tttgcggcaa aacggagaca 1978261 aatgatagga aaaacccgct tactcccatc tgattgacta ggaacccgac agtaaagccg 1978321 acgacgatcc ctttcagaaa gatcataatg aaaataatcg gcatcccaat gacggaaatt 1978381 cccagtatcc acatcaggcc taaatacttt gcattatgaa agatactttg cccaaacata 1978441 tcagctgaac ttgcctgttt tccatccgaa agctgtccaa aaaattgact taagtagtag 1978501 tataaatctt ctttctggct gatggtcata ctgttgacaa taatcgcgcc aaagatgaca 1978561 cccatgaaaa acagcactga cacaaatata taaagagaga gatgatcttt gacatgcctg 1978621 agaaacatgt ccttataaga gatttttcgc ataccgtttc ctcccgcccg ctctagtgat 1978681 ttgatttaat agattgtatg aaagaaacag aaaaacatgc cctttttcaa aaagaaacaa 1978741 tagagatgaa tgctaggcgg ctttttgggg cacaaaaaaa tccttatcat caactgctgt 1978801 atgatcataa ggattcttat gcttccgttt attcaaaatc tcttttttgc tttttgtcat 1978861 tcttccatgt gtgctgaaag atggtgtgct gcctcttgat aataagacgt cacgtccgcc 1978921 gtttctcaat cgatgccccc gcttcttttt cgcttggctt tttgccatgt gatcactccc 1978981 ttttttattt tcatagtaat gataacaaaa ttgaacaatg ataagaaaaa aacagcacct 1979041 gctacgacag gtgctgttta gctacattta tttcactgct gtaagagctg catgctcgac 1979101 agctgctgct accgcatgat ggacttttga atcaagcggc tgagggacaa catcaccttg 1979161 tttagtgcaa gctgcgatgg cctctgctgc tgcgacaagc atatcatgat taatctccgt 1979221 gctttttgcg ttaagcgctc ctctaaaaat ccctggaaaa ccgagtacat tattaacaga 1979281 acgcccgtca gctgcatatg cggcgccagc ctgcagtgcg gcctccggct caatttccgg 1979341 cttcggattc gataaagcca gaatcacttg accagaacgt acaaatgccg gttttattaa 1979401 acccggaacg cccgttgtag caatgacaat atcacatgtt tccataagct cctcaatact 1979461 ggaaactgcc tgtccgccgt attgttcgag acggttcatt gctgactctg atttgtctgt 1979521 tccgtataca gcattcacac cataagccat gaacatccgg cagatggcca cgcctgctgc 1979581 gccaaggccg atttgcccca ctttcgcttc cttcaggtca acccccgcac tcctgcatgc 1979641 cgaaatggca gctgccagcg tcactacagc tgtaccatgc tggtcatcgt gcataacagg 1979701 gatgttcagc tcctctttta ggcgatcctc gatttcaaaa caatgcggcg aaccgatatc 1979761 ctcaagaagg atgccgctaa agcccggaga aatatgtttt actgttttga tgatttcttc 1979821 aggatcactc gtatcaagca gtatcggaat gccgctaata cccgccagct gatcaaataa 1979881 agcagccttt ccttccatga caggcatgcc agccacagag ccgatattcc caaggcctaa 1979941 aattgcggtt ccatccgtta caattgcaac agaattgctg atcgttgtat aaatagaagc 1980001 tttttcaggt tctttttcga tcagtcggca cacgtccgca acacctggtg tgtagacacg 1980061 tcccagctct gccagtgaac ggatcggcat tttgcttttc atttggattt ttccgccttc 1980121 atgtgcggac aggacttcat cagatacggt gtgaagcctg atcccttctc cgagggcctg 1980181 tacagccgcg atcacttcct gaagctgttc ttcattctcc acttgaacgg taatattccg 1980241 cattgtgtaa ttgggtccga cttttaccgt ctccacttca ccaatatccc cgcccagaag 1980301 gccgatggcc gtagccaccc ttccaagatt tccgggaacc gaaggcgttt cgatcatcag 1980361 tgtccgaatc atgtgtttcg ctatcattca gtgatcctcc cctattagcc tagtttttcg 1980421 gctttaactg tattgttttt cgtataccat ataaattttc ctgtataacc atagataatt 1980481 gcaagaccta ttgctacaaa actgagccac ataaacggca gataagagaa ggtagaaaca 1980541 cctaaaatac cagccatgta aatcccatta tcagaccaag gaaccatccc cgaagtcaat 1980601 gttcccccga cctctgagtt acgtgataac actcttctgt ccagatgtaa gcgatcatag 1980661 ctgtcttcca taattttcgg agtcaaaata agagatacat acatcgcaca gccgaagatg 1980721 tttgctaaaa acgctacgat cagtgtagac aatgtgacat tgccggctga agttaatttc 1980781 ttttcaaacg ttgaaacaat gacttttaac acgccgagtt tctcaagcag accgccaaaa 1980841 ccaaggccaa agatgatgac gacgagagaa tcaagcatac cgacaattcc accgcggttt 1980901 aacaagccgt tcaaaaattc aacatccgtt ttaatagaga agccgttgta cgcagttgca 1980961 atcgcatggg caatatccat tccttggaaa acaacagccc agattgcacc gagtaaagcg 1981021 ccaattacga taactggcat agatggcttt ttcatcgcca ataagactat gacgagaact 1981081 gccgggatca gcatccaaat atgaatgtca aacgtgtttt gcaaagatga ttttaagaat 1981141 tcaactttat caagatcaat atttttcccg ccgtacataa atccaacaac tgtaaagagt 1981201 atagctgtaa tgacataagc aggtattgat aaataaagca ttgctctcac gtgagccaat 1981261 acatcgactt ttgatagtga agaagctaga actgtactgt cagacagcgg agacagcttg 1981321 tccccaaaat aagcacctga aagaatagct cccgctacta gaggaagcgg aatgcctaac 1981381 ccctctccaa ttgcgatcat ggcaatgccg gcagttccga ctgttcccca tgacgttcct 1981441 gttgccacag acataatgga acaaataatt aacgttgcca gtaaaaagat acttgggtga 1981501 ataaattcca gtccgtaata aatcaaagtc ggcacaacgc ctccggcaat ccatgttccg 1981561 atgagcgccc caactgaaac gagaatcagt acggcttcaa ggccatttga tatcccatgt 1981621 acaatcgcat tttgtaaatc tttataagaa taaccgagtc taatacctaa aagcattgca 1981681 ataaaccatg aaacaaaaag cgccagctgt atcggcaagt cgagaaagac tgtaaacgat 1981741 agaacaagtg ctaaaaatac tcctagtaca ataataattt caaatagtgt tggcaatctt 1981801 acatccttca aaagaagtcc cccttcatgt aaaagctaaa acgctttcaa tatatagtgc 1981861 aacacgtata ctatacttcc tcatccctat gttgtaaaca gcttattcat ccgactattc 1981921 ggagatgaat aagctgtatt ttatacaaat tttatttttc taatagttct ttccctgcga 1981981 tacctggttt ggtcatctca tatgggttta aaataatatc caattcttct tcagtcagca 1982041 catcatgctg cagacaaaga tcccggacag attgccctgt cataattgct tccctggcaa 1982101 ttctagctgc cgcttcatac ccaagatgcg gattgacagc tgtgatcacg cctgcgcttt 1982161 tttctacgta ttgcttcata cgcttttcgt tggcttcaat gccttttaag cagttgtcag 1982221 tgaacgaacg gaagccgttg ttcatgatgc tgatggattg aagcaaatta aagacaagca 1982281 cgggctccat gacgttcaac tcaagctggc cggcttctga agcaaggcag attgtattgt 1982341 catttccgat aacctggaac gcaatttggt tgatcagctc cgccataacc ggattgactt 1982401 tccccggcat aatagatgaa cccggctgac gtgcaggcag agaaatttcc gcaagtccgg 1982461 cgcgcggtcc cgacgccatt aagcgcaggt cgtttgcgat cttcgacatg ttcatcatgc 1982521 agacttttaa tgaagctgat acctctgtat aggcatctgt attttgtgtc gcatcaacaa 1982581 gatgatcagc gccgacaaga ggaagcccgc taatatcagc aaggtgcttt actacctgtt 1982641 tgatatattc aggatcagcg ttcagccctg taccaacagc agttgcgccc atgttgactt 1982701 catacaggtg ctggcgcgat tgcttgattc gtttgatatc acgctcgaga acacggctgt 1982761 aagcttcgaa ttcctggcca agacggatcg gaaccgcatc ttgaaggtgt gtccggccca 1982821 ttttaataac agagtcaaac tcctgtgctt tttgcttaaa cacactatgc atatcttcca 1982881 ttgttttcag cagtttttct aagagcttca atgtggaaat atggatagca gtcgggaaca 1982941 catcgttcgt agactgtgac atgttcacat gtgtgtttgg acttaaatgg atataatctc 1983001 cctttttatg tcccatgatt tcaagcgccc ggtttccgat aacctcattc gcgttcatgt 1983061 tcatagaagt tccggcaccg ccctgaatcg gatcgacgat aaactgatcg tgccacttgc 1983121 cttccagaat ctcgtcagcg gcttgtacga tagcttggcc aattccttca tacagccgtt 1983181 tcacgtccat gttggcaaga gccgcagctt ttttcacaat cgccagtgcg ttaatcattt 1983241 cctcatggat tttgtatcct gtgatcggaa aattttcaga agcacggagc gtctgaattc 1983301 cgtaataaac atctgcttca atttgttttt ccccaaggaa gtctttttcc acgcgatatt 1983361 ctttttggcc gtttaacata atctttaacc ttctttctct ttgctggtta tcgtttttac 1983421 attttacagg acaacgtcat cagctatcgg cgtttccata attctcttga cgacaggaag 1983481 atccgaagac tgacctagcg cccacatcaa ttttggcaca attgcttctg tgttcatatt 1983541 tcttgatcgg ataattaagt cttggttgac tctgcggcca acctcgtaaa tgctcatgtc 1983601 ttcgccttct tcaagacatt gagtcgtaat gacgacgaca atgccgcttt cgatcagttc 1983661 attcactttt gacaaaatgt ctctgccttc aaacggcact cctccgctgc cataactctc 1983721 aatgacaatt cctttgtaca tgcttttcag ggcatcaaac atttcgggct ttaagcctgg 1983781 atgcagcttc agcagacata catctgtgca tagtgaagtg tcaactgtga aggtgtcgtt 1983841 ctcaggttcc gttacttgtt tgttgtattc gatcccgtct tcattgataa aagcgatata 1983901 tgggtaattg atgctttcaa atgcgtcgta gcttttcgtt cttaatttga tcgcacgcgt 1983961 tccctgaatg actctgccgt caaacacaac ataaacgccg cccacgcctt cacaggcaaa 1984021 tcgaatggca tctgtaatat tttttttggc atcggttttt tggaacgtga tcggaatctg 1984081 cgagccggtg atgacaatcg gctttttggc atgctgcagc atatacgata gtgcggcaga 1984141 tgtataggcc attgtatctg taccgtgagt aataacaaac ccgtcatagg catcataatt 1984201 ttccttaacg gcttctgcta tttccaccca gtattcaggc tgcatattgg tgctgtctat 1984261 attcataagc gactgagttt ccattgtgta atcgttatca agttttgata cgtaacttaa 1984321 taattcatca gccttgactc cgggagccag cccattttcc ccttcaactg aagcaatcgt 1984381 tcccccagtt gtcaacatca ataatttttt cataccatgc acctcttcac tgtatctaaa 1984441 gatgggttgc gagaaggtat tcgcttttcg catactttta atgcaattat agacacggaa 1984501 aataaaatac gcaagacatt attattcaat tcgcgtacac ttcctaatac ctatatgata 1984561 taatcagctc aaggtgaaaa aggagcggaa gttcatgaat ctagatcgtt taactgaatt 1984621 gagaaaaaag aaaaattggt cgcttcaata tacagctgac cttctcggta tcgcaaaaag 1984681 cacatatgcc ggctacgagt caggctaccg acggccttca cttgaagcgc ttgccatgct 1984741 ggctgacctc tttgacacaa cctgcgatga acttttaggc cgcgagaaac aaaagcagac 1984801 tgctcctcag gccatagaat tggccacgtg gagcagcctc gactttacca tttctgttga 1984861 tggccagccg ctgagtgaag atgaaatcat ccagctgatt acctttatac gcacaaaaag 1984921 aaaagtacag gaggaactga gttaatcttt agctcacggt ttaattttac cgtaggttcc 1984981 tcctcctccg gctttcaatt ccagttttcc ggatctcgct tttacgataa gcgccgcggt 1985041 tttcggcggg acaacgcgag ccaaatcttc ttctgcagcc tcatgaagaa cagccatttc 1985101 tgttccgaag gcttttttta gtttgtccag cgttttcggg cctacacccg gaacaaattg 1985161 cagcgggatc tgatgtacat atcgcggacg cgggacgcga acttcaagct gatcactcaa 1985221 ttcacgcaat ctatcgctga ctcccttggt aaatctggct tttccgcaat tcgcgcacgc 1985281 tgtttccccg cttacagcag gctctccgca cgcttcgcaa gccgtctgat aatatttccc 1985341 caataacggg tccaagccat aatttgcgat aattttcctg tcatcttgtc cctttaatgc 1985401 aagagcaaat tcagtaaaat cagctgactg cacatataat tcattatatt ctctgccgat 1985461 tttccccaac gaatgcgcat cagaatttgt taaaaaagga tacggattca attgcgatac 1985521 gtgtgatgcc atgtctgtat cacagcttaa tccaagctcc accgcgtcta tcatagatgg 1985581 atcaaaaacc tcagttaagc ttgatttaac cccttttcca tataagcttt tatgcggcgt 1985641 aaagatatgg gcggggataa acaggccgcc catatcctgc actttttttt gcaggtttaa 1985701 gcccgtttca taaatccgct gcgagcttaa atgaatattt ttcagccggg ctgacagcca 1985761 gtttgaaaac tgtttcatat cagccagcgt cggcataaat acgagcacat ggatcggtcc 1985821 gctgcaggct tcatcataaa tctccagctc gctccccaat aaaagagtcg tgctgcgata 1985881 acggattcct cccccgtcaa gctcgcgata ttttccagat gaaatgcctt cctcaagctc 1985941 tagaatgact tccggagaat gacagtcgat aatgccgagg agttcaattc ctttatgttc 1986001 actggcttca accaaaattc tgtccagcgt taatgttttg gcgcctgtta ttttgacagc 1986061 ccttcctgta aaggtccggc cgatatgaat gtgcaaatcc gcgtaaatct ttttcatttt 1986121 tgtgcttgga gcgcttcttt cagctgaaga tactgaatcg cgtaggctgt tttagcatca 1986181 tatacttcac gcgattcaac cagctttagc gcatcttcaa gcgtcacctc catcacttca 1986241 acaaactcgt cctcatcaag ctcccgtttt tcttcaagca cagaaagctc ctcagcaaga 1986301 aaaacgtgaa cgatttcatc tgcaaatccg ggtgatgtat aaaacgcagt tatttttgtc 1986361 agtttttttg ctgtataacc ggtttcctct tcaagttccc gaagtgccgt atactccggc 1986421 tcctcacctt tttcaagctt accggccgga atttcaacga tcgtccgctc aagcggctta 1986481 cggaattgtt tgaccatgat gattttccct tcatctgtga cggctagtac cgctacagct 1986541 ccagggtgtt tcacaatttc acgtttactg gctttgccgt ttggcagctc tacatcctcg 1986601 acataaagat caatgacttt acccgaaaaa atctgttctt tggcaattgt tttttcttct 1986661 aatgatttca tttcttcatc tcccgttctg tctctatatg atgccccata cattttatca 1986721 tactagagca aaagggggct tcttcgtgaa agtgcaccgc atgccaaaag gtgttgtctt 1986781 agtcggaaaa gcatgggaaa ttcgagcgaa gttaaaagag tatggacgca catttcaata 1986841 tgtgaaagat tggatctcaa agccataaaa gttgaaactt tagctccttt atattacggt 1986901 caatacaaag cctaaaaaag gagtgtgcac atgagaaagc gcaaattggg tacatctgat 1986961 ttagacatta gcgaagtcgg actcggctgt atgtctcttg gaactgaaaa aaacaaagca 1987021 ttgtccattc tggatgaagc gatcgagctt ggcatcaact atttggacac agcggatttg 1987081 tatgaccggg gacgcaatga agaaattgtc ggtgatgcga tccaaaacag acgccatgat 1987141 attattctgg caacaaaagc gggaaaccgt tgggatgacg gaagcgaggg ctggtattgg 1987201 gacccttcaa aagcttacat aaaagaggcg gtaaaaaaga gccttacacg tctgaaaaca 1987261 gattatatcg acctttatca gctccacggc ggcacgatag aggacaacat tgatgaaacg 1987321 attgaagcgt ttgaggaatt aaaacaagaa ggtgtcatcc gctactacgg catttcttcc 1987381 atccgcccga atgtgattaa agaatatgta aaaaaatcaa acatcgtcag cattatgatg 1987441 caattcagcc tgtttgacag acgccctgag gaatggctcc cgcttttaga ggaacatcaa 1987501 atcagcgtag tcgccagagg tcctgttgcc aaagggctct taactgaaaa accgcttgat 1987561 caagcttcag aaagtatgaa acaaaacggg tacttgtcct attcattcga ggaactgaca 1987621 aatgcccgta aggcaatgga ggaagtggct cccgatcttt ccatgacaga aaagtcgctg 1987681 cagtatctgc tagcacagcc ggctgtcgct tcagtgatta caggcgccag taagattgag 1987741 cagttacggg aaaatattca ggcagcaaat gcacggcgtt taaccgaaga ggaaatcaaa 1987801 gcgctccaat ctcatacgaa acaagacatt tacaaagctc atcgctcata gcagaaaaac 1987861 cagcacctgt acgggtgctg gtttatttat attgatgcca atccatttgg ctttcattta 1987921 ggagttcttc aaagctctta tttttttcga tctctttttt ctttctaatc tgttctgctt 1987981 tttctctttt ctgcctcttt tcatcctctt ccttcaattg gctcttcatc tccataagct 1988041 ttgctttgat atcggattga aggccgtctt ttagctggtg tttgtcaatg gatttttgtt 1988101 ttttcatgca gacttccccc atgttttgtt ttgaagccag tttatcacgg agcatataaa 1988161 ctgaacaagc agactctctt ctgatcactt tctcagcgta gcagtgttta ggtataatga 1988221 tcttaaacac gaattgccta tatatttcgt tgaaaggtgc tgtgactttt gaagaaaatc 1988281 cttttggcca ttggcgcgct cgtaacagct gtcatcgcaa tcggaattgt tttttcacat 1988341 atgattctat tcatcaagaa aaaaacggat gaagacatta tcaaaagaga gacagacaac 1988401 ggacatgatg tgtttgaatc atttgaacaa atggagaaaa ccgcttttgt gataccctcc 1988461 gcttacgggt acgacataaa aggataccat gtcgcaccgc atgacacacc aaataccatc 1988521 atcatctgcc acggggtgac gatgaatgta ctgaattctc ttaagtatat gcatttattt 1988581 ctagatctcg gctggaatgt gctcatttat gaccatcgcc ggcatggcca aagcggcgga 1988641 aagacgacca gctacgggtt ttacgaaaag gatgatctca ataaggttgt cagcttgctc 1988701 aaaaacaaaa caaatcatcg cggattgatc ggaattcatg gtgagtcgat gggggccgtg 1988761 accgccctgc tttatgctgg tgcacactgc agcgatggcg ctgattttta tattgccgat 1988821 tgtccgttcg catgttttga tgaacagctt gcctatcggc tgagagcgga atacaggctc 1988881 ccgtcttggc ccctgcttcc tatcgccgac ttctttttga agctgagggg aggctatcgc 1988941 gcacgtgaag tatctccgct tgctgtcatt gataaaattg aaaagccggt cctctttatt 1989001 cacagtaagg atgatgacta cattcctgtt tcttcaaccg agcggcttta tgaaaagaaa 1989061 cgcggtccga aagcgctgta cattgccgag aacggtgaac acgccatgtc atataccaaa 1989121 aatcggcata cgtaccgaaa aacagtgcag gagtttttag acaacatgaa tgattcaaca 1989181 gaataaaaaa gcgaaaggcc tcttcggctc tttcgctttt ttatgttaca gaacgtcggt 1989241 aatgccatcc atattttctc tgatccattc aatcgcaaga tctatcgttg taaactcctg 1989301 cgtctcgaag gtcatttcat cctgcaatag ccagacatct ttcttgatgg actctgctcc 1989361 tccgattgac cagtgaagca aggtataagg atggttttga ttcaggaagg atacccacgt 1989421 tttattttgt gctgtgttct tcattgcctt cagcttttgt tccacgtttc gcgtctccta 1989481 ctttactaat atgctcattc tggggctgag catttcagcc gggcttttca gcgccaatgt 1989541 tttggctttt tcattgtaat cgatcgtcat ttgatcgtca aaaaacactt tttgcgacga 1989601 ttggatatac agcggaatgc cgttcgtttc cagctgctcg cactgtcccg ttaattcttc 1989661 tgccagccag attgtcggga caccgcttac cgcgcagccg catccttctg catcgtaacg 1989721 aagctgggct ttttttcccg ggttggcgtc aaacgcctgc tgcagtgcct gttttgctgc 1989781 atctgtcaca tgtatgttca taaggtgaaa cccccgtttt catcattttc gctattgtag 1989841 catacaatac tgccattcgc attgtttctg ccttttttcc accgcttcgc attttcttct 1989901 gcagtcttga tccactcatc tttcccttgt atatactgat tgatgctgtc agggtgctgg 1989961 gccgccagct gttttttgag aacggcgtat tctttcgcta tgtttggatg agctctgaga 1990021 taatctctga ataacagatg cctttcaata gcagggtttc cctgttcgta catatggaca 1990081 tgatgagtgc gtttatttcc gcccttttgg aaataacgcc tgcccgctat accgttctca 1990141 ccttttggtg tatagccgtt ggccttcatt tgttcatcaa attggctcac ggcttcaatg 1990201 cttctgactt caattaacat atcaatgatt ggcttcgctg ccatgttagg tattgatgtg 1990261 cttccgatgt gatgaatagc gataatctcc ggcccgaaca caagtttcag ccgttctttt 1990321 tcttcatcga aacattctgc ccatttttcg ttgtagagaa tgatctcaac ttttcttttc 1990381 ggatacaaat gaaagaccga cagcaataga ccctgcgctg ctttgacggt ttctgccttt 1990441 tggaatccgg cctgtgtata gagtgacaca gccggggtat tgttctcggc tgtgactact 1990501 tcgattttct cagcgtcttc attatgatca atgacaaatt gcagaagcgc tcgtccaatt 1990561 ccttttctga aaccgtcagg atgcacaaca agcctgcaaa tggtgagata atgcatgttt 1990621 ttctcatatg aaatgacacc gatcagcttg ccgtttttcc gatatcccgc aaaccgttca 1990681 tgggatgctt gaatatcctt taccttctct tgtaaagcgg gaataccgtc aaaaccgata 1990741 atctctgttt cctttatgta ggcggggatc tgtacggcta aaatctcacg cgctatagtg 1990801 gcttccttat gctggagaaa ttcaatcatt cgtgttctcc tgaaacagcc gctgtctgtc 1990861 gacttttgcg acgcggactg catacgactc gtaccaaacg cttcttcctt tttcttttgc 1990921 tgcttgatgt tcagtgtgat gcctccaatg gttaattgcg tccatactgt cccaatagga 1990981 aactgtgatg ccccttccat ccgcttcacg tacgctttcc acgcctaaaa atccaggctg 1991041 atccgccgca agtgatacca tccgctccgc tgtttctcca tatcctgtgt cattttcgct 1991101 tttgacagaa gaaaaaatga ctgcatagta aggaggctca ggtgtttttg ataaaaaatc 1991161 catcatattt ccccctcata tgtttttgac aaatagtacc ctgtcttggc ccgggccatc 1991221 atagtttgca aacactgaga tgccatttac cgttttggtg cccttttcaa tatcaaaccc 1991281 caattttgtg tgatatgcga ttgatacctt attcacaggt gaagtgacac acttcacccg 1991341 ggtgcagccc ctttgtttta ctgtttcgat aaatacatca tacaattgtt tcccaatttg 1991401 catttttctg aaatccggat gcacaccgga aaaatgaatg tacgccgttt caggatcgga 1991461 ttgcgattga aatccgatta aaaatcccgt catgctgtta tgttcggatg taataaagct 1991521 tgtgtcctga aaatgctcaa aaaatagtct cggcaatttt tctttcagct gtctgccgcc 1991581 ccaccattca ttcagtacag acgttaccat ttcataatct gaagacgtga ttgttcgaat 1991641 atccattacg atttgatctc cctccgtctg gcaaaacgaa tgtcagctct ttttctcaca 1991701 atataaaaat tatattttgc ctggctggaa ttgtaaatgc cttctttcct gtatcatacg 1991761 tttccagact gccgagggaa caatgtttga tcattttacg cctatttctc ccccaaacag 1991821 gaggagagac tttacagcac aatatcaagc acttgatcaa gtttcagctt ataaagctga 1991881 tcctcgtctc cttttatcca tactgctttt tcaaactctt cataccggca gattttcccg 1991941 gtgcagcaga caatctcacc gtcctgaaag cagctgacag tgatatcctg agcaaactcc 1992001 atcgcggcgc aaagcgtttg attcatctct tccagcttat cggggtcaag gatcggcttt 1992061 tgcagcttct gtttaagtcg ctttctctcc agcaggcttt gcttatgttc cggcagaaac 1992121 atcctgctcc cttcccacag caggttgccc ctttttaaat ggtcgttcat ttataatgcc 1992181 cccctatttt agccgcacgt tcaaatgcct ggcctgccgc tgtcagtgac gccgccctga 1992241 tgattgctgt atcgccgaat cgatttttaa tgccatccat cacatagcct aggctcattt 1992301 tctttgcata atcctgaaat aaattgagct gccatatgtc atcagatgag agctgagaca 1992361 gattgacacc gaggcggcgg acgggtttcc cgtcccaaaa tgtaagaaac agccgtcgta 1992421 cagcctcata tacatcctgc gtagaattag tcggctctgc cagcttcact tgccggttga 1992481 agcccgtcgg ccaatcaaaa tcagcacccc ggcagctcac tgacactgtc tgccccatga 1992541 ccccggcgtt tcggcttcgc ctgcacacct cttcactcag ctcaagcaat acgaccttga 1992601 tttctttgtc aaagtgttcg tagtctctcg ggagagtcat tccatgacct atcgcctttt 1992661 gcccgtccag agacgaagtt gacacagggg aatagtcgat tccgtttgcc gtcatccaca 1992721 gcacgtggcc gttaatgccc catttctttt ttaaaagatc gagcggaaaa gccgcgagcc 1992781 cgccgatcgt gctgatgccc attcgattta aatgatgctt catgcggctc ccgacgccaa 1992841 acatgctgcc caccgggagc ggccacattt cggttttcat attttctttc gttaaggtaa 1992901 aaataccgtt cttattcttt ttggcaaaat tgtcacacgc aattttggcc agcgctttgt 1992961 tagggccgat tccgacccgt gcataaacgc cgatctcccg catgattctg ccctgaatgc 1993021 ttttcgcgat ctccatcggc gtcccaaaca gcttctggct gcctgtaatg tccatgaact 1993081 gttcatcgat ggaatacggc tccacaaggt ctgtatactc ctcgagaatg gccgtaattt 1993141 gcagtgatac atcaatatac cgctgcatac gcggccggag cacaacagcc tcaggacact 1993201 tttcctgcgc ctcccacagc cgtgaagcat tcaccacacc cttttgtttc gccagcgggc 1993261 aggcagccaa tacgactccg cccctttttt cagggtcacc cgaaacaatg acgggcctat 1993321 ttttcaaatg tggattttcc gctttctcta cagatgcata aaacgattgc atgtcaacga 1993381 gaaaaatcac tttttctttc atcatacaca cctctaaaaa gaacttatgt tcgcttttca 1993441 ttatatgcga aagtatgttc gttttatact ggtaaatgat tcttgtctga cagaaaatat 1993501 gatccaaggg tttgagagaa gaaaaacatt tagtagaata aaagcgaagc ataaggatag 1993561 gagagtcatg atggagaaat ttgtcgaaaa aatgctggga caggcattgc ggcaatacgg 1993621 cagaaacgtt gctatagatc cgttaagccc gtatgaaaaa caaagcctga aagcggctct 1993681 acaagagaga cggaatgaag aaccagatga ggatttgcat gcgcatatag aagatatcat 1993741 ttatgactat gtcacaaacc aaggcctgtt ctcttaaacg catgactgtc agttctttca 1993801 gccgctgatg cggcttccct ttgaaaacac cgcctgaaac aaataaacag tctcaggctt 1993861 acagaaaaaa agcaggattt tctcacgctc catagattca tatggcctgg cgtaaaattc 1993921 ccctcaatgc tcgcgcaaaa cggaataagc tgtccatgat cacgcgtata cactttttcg 1993981 aagagatgtg ctctcttgtt ctgtcatgcg gtccatgccg gttttcagcg tacatcttga 1994041 tctcatagcc ggtttcactg ccgatatgat ccacgttctg gcggcttaaa ctaacacacc 1994101 ctcactgacc aatcgctttg cttttcatcg gacatcccgt cattttcctt ctttcaagat 1994161 gtaaactccg tcagccacac gcatcctcaa cgcatagtat attgccatcc atacaatcag 1994221 gcatactaca tgtcaataac gaaatatttt gaacgatcta ttggagaagg aaattttttc 1994281 atatatgata gagaaagatc atacatacag gagagaatat aattcatgaa gaaatggaaa 1994341 gatatccacc cgatcagctg gacaattata atcggaacca ttttcggcag aatggcaaca 1994401 tcgatgagca ttcctttttt agcgatttat ttgacagccg tccaaggcgc atcagcttcc 1994461 tatgcagggc tggtcatcgc cgcgagctca tcagtcggca tcctcgcaag cttttacggc 1994521 ggatatatct cagataaatt cggcagaaaa aacatgatgc ttgtatcgat tttcggatgg 1994581 atgctggtat ttgcaggctt tgcggcagca tctaatctct gggtgttttt tgtagtaaac 1994641 gcattaaacg gtctttgcaa atcactgttt gagcccgctt caaaggcctt gttgtctgat 1994701 atgacagaag aaaaaacgag actgctagtt tttaatttac gctatgcggc tattaatatc 1994761 ggcgttgtct tcggacctgt gcttggccta tatttcggct catcgcaatc gactacgccc 1994821 tttttggtgc ctgcagtcat ttacggacta tacggaattg tgcttgccct ccaatttaaa 1994881 aaacatccat ccttatcagc accagcccag tcccgaaata tgagcgtgcg ggaagcgttt 1994941 atggtcacgc aaaaggatta tctttttacc attgctttgg tcggcattac gctatgcacc 1995001 ttcggctact cacaattcag ttccacattc cctcagtata tggcgcagaa ccccttgatc 1995061 ggcaatggaa cgaagctgta tgggctgatg ctgacattaa acgcaatcgt tgtgttggcg 1995121 acgcaatttc ccattgtcca ttttgcaaaa cggttttcgc cgctttgttc tctgatgctc 1995181 ggtaatgtga tggttagcat cagcatggcc attttcaccg tatcacacgg tgttccatca 1995241 attgtgatga ttgtcatcac atttacaatc ggcgaagtgc ttttattctc tatgatggat 1995301 ttgtatgtag accagattgc aaaaccagga ttaaaaggca cttatttcgg ggcaatcggt 1995361 ttttcacagc tcggaaacgt catcggccct tgggtcgggg ggatatgtat agacctgttt 1995421 ggcgctggcc ggccgattta tattttttct gtcctgagcg gcattaccct gctcggcctg 1995481 ccatttttag cgttcgccta tcggcaaatg aaaatggaga ccacaaaaca ccgttcccgt 1995541 ctggaaaagc cgctttaaat aaaaaacgga agagaatgaa tctctcccgc aaacatgagg 1995601 tgaagaacat gaatataggt gatgtgatgt ttcagctgtt tgtatttatt atatttgccg 1995661 ctgtcgtctt tgcggctgtt acaggcttca agtatgcgaa aaaccgaaaa gcgcagctgg 1995721 atcgcattga gaaaaagctg aacagcctgt ccgaagatca cgattaacag cttggggcaa 1995781 cgagctctac cttaatccgg tctggatcct cacaaaagac tgcataatgc ccgtctcctc 1995841 cggcaaaagg atgcctgtct cggtacaaca cacgatagcc ttttgccgtc aatttttcag 1995901 tcatctgatc gacttgaagc ttggattcag catgaaatgc gagatggttc agaccgactc 1995961 ggcatctatg gtattccggc tctagaaatg gctctttcgc ctgcacaatc actaggtaaa 1996021 aacgatcttt cttccagctg atgcctgagc tccatttttg atactcttta taaccaagtt 1996081 cttttaagaa ccagccccaa aaccgcctag acgcctccaa atcagagaca tacagttcaa 1996141 tatgatgcac atttcatacc ctccttacca acacttcctc gaccttatgc ccgtctccct 1996201 tacgcaaaat gagatctgac ctgaatttag ttggcaaaat attttcatat aaattcggcc 1996261 ggttgacact ctcccaaatc gaggctgcca tctcgtcagc ctcctgatcg gacaagtctt 1996321 taaatttatg aaaatatgaa tcaggatttt gaaaagctgt ttcccgaagc aggcgaaaac 1996381 gctctaaata ccaagtgaaa atccggcttt cctccgcatc cacataaatc gaaaaatcaa 1996441 agaaatcgga aacaaaaata cgcgggtttt cccggtcatc ctccaaggtg ggcgactgaa 1996501 gaacattaat gccttcaata atcacaatat ccgcctgttc tacaacctcg aacacacctt 1996561 cctcgcggtc ataggttaga tgggaataca ccggggcctt tacgctgtcc tttcctgatt 1996621 ttaagtcatt caaaaattcg agcagcgcct ttacatcata gctttcagga aatccttttc 1996681 ttgacatcat atttttcttt ttcagctcgg cagtaggaaa taaaaaacca tctgtcgtga 1996741 taaggctcac ttttggacgg tcaggcaaac gcgaaagcag cttctgcaag atccgcgccg 1996801 tcgtgctttt tccgactgcg acactgccgg caatgccgat aataaacgga attttggctg 1996861 aatgtgggtg cttcaaaaaa acattgacat gcttattgcg ttcagccgca gacttgacat 1996921 gtaaatgaag caagcgaaca agcggaatat agatcgtctc cacttcttca acagatagat 1996981 aatcattcaa tccttccaca gcttttgcct cttcttcaga tacagcaatc gacaaatgcc 1997041 ccccaaaacc agaccaagac tcccgattgt gctgtgtata taaagtatgt aggttaagtt 1997101 ctttattttt cactgtttac acctgactct ctgtaggtta aaacccttac aaagattgta 1997161 acggaaaacc ttttcactgt ctgcttattt ttcatttcgt ttttttagca aatcagcacc 1997221 gattcggtta tacgcagcca tttcatcttt tggaaccatg cttcctcccg ttccccagac 1997281 gacatgtacg gcatgttcca tcttatattt ctgagcatag cgccttccct cttctgtcga 1997341 aaaaagctga accggcccga acatgccagc aagagcagag ggctctaaat atttatcttc 1997401 agatacagcc agcatatgaa gcaaagtata aagcgtattg tcctctaccg tataacagcc 1997461 gctcagaagc ggttcaatca gcttgccgac aaatcctgac ggcctcccta cggcaagtcc 1997521 gtcagcagcc gtctgattat ccaggccgat atcctggacg gagatcttct cgtgaagtcc 1997581 tgaataaagc cctaacagca tacaaggtga atgagttggt tctgcgaaaa acacatgaac 1997641 atcatctccg tataaaagct tcagcccaaa tgctacaccg cccggtcctc cgccgactcc 1997701 gcacggcaga tacacaaaca agggcgtctc aagacttggc tttatattca tacagtcaag 1997761 ctgtgttttt aatcggcttg cagcaacagc atatcctaag aacagctgac gagaatgttc 1997821 atcatcaata aaataacaga atggatcttg ttccgcctgc cgtctccctt cgttcaccgc 1997881 ttcactgtaa tctgtttcgt actccataac agtgactccc ttttggcgga ggagatcctt 1997941 tttccactgc ttagcatcgg cggacatatg cactgtcacg cgaaacccga gtgccgcgcc 1998001 gatgatgccg atgcttaaac ctagatttcc tgtcgaaccg acagcaatcg aatagcggga 1998061 gaaaaacccg gtaaaccgct cttcctgtaa gatgcggtaa tcatcggttt cctgaagcat 1998121 tccttcttga agcgcgagat tttcagcata ctttaacact tcataaatcc cgcccctcgc 1998181 tttaatcgat cctgaaatcg gaagctcatg gtcgcacttt aaaagccatc ttccgggaaa 1998241 tggctgctga tatgccgctt ccagctttcc cttcatatgc tgcacctcaa aaagcggaga 1998301 ctcgatgatt cctttagcgc ctttcgtctc aggaaacacc tcggcaatgt aaggtgcaaa 1998361 ccgctgcatt cttttttccg cttccgctat ctcggttgcc cactcatctg cacggggtaa 1998421 tggcccctct ttcttgcctg aatttgccca gaatacaggc tctgcatcaa tcagtttctg 1998481 aataaacgga tctttaagca gagcatgaag gacttctgaa tgaactgaca ttcaacaatc 1998541 tctcccttcc actatcaaaa actgccccgt gagaaacaag ccactccacc acaggcagtt 1998601 ctatcattat tttttcatga gcgcgcgtcc tgccagcttt tctacaagag ctggaaacag 1998661 ctgatacagc ttagtgccgg cattcattaa acgcggaaga ttgatctccc gctttttcgt 1998721 aaaaattgca gctgtaattt gagctgccac gtcatcagga tcaagcatcc agcggccgac 1998781 atttttggcg tagtccccgc ctttatcagc aatggaaaaa aagtccgtct gaatcgggcc 1998841 cgggttgact gttgtcacat aaatgccggt tcccgaaagc tccatccgca aagcgtttga 1998901 gtaacctaac acggcatgtt tggtcgcgga atacaggcta gacttcggtg tggcgatttt 1998961 ccccgcttga gaggcgatat tgatgatatg tccctttttt tgctcaagca tttgcggaag 1999021 caccgctttt gtacaggcga tcaggccgaa gacattcaca tcaaacatcg ctttcatgtc 1999081 atccaatgta gagtctaaaa ccgtttcaaa tataccgaag cctgcattgt taatcagtac 1999141 atcaatcgag ccgatctgat cgcggacccg ggcgatatcc tctaggcggc cgacatccag 1999201 aggaaaaatc tcacactgtc cgctccattc ctcggttatt ttccttttga tttctatcaa 1999261 acgatcctcg cgtctagccg acagcaggac atgggctcct tcagccgcgc ataagtatgc 1999321 gattctttct ccaagccctc ctgaagcgcc ggttatccaa atcctttttc ccgctatatg 1999381 tttcacccat ttcacctctt cattgtttta aagtatacgg tatttccttc ccaatatgac 1999441 gtgatggctt cttcagcctc caacacatca aggtgacctg ccgtttctga catcgttaaa 1999501 aacaattcct tttcatatac agcaggaaaa agctgctgac agacctgaaa agcggtcatc 1999561 ggcttttcat ccagcatgcg acgcacatcc tccgtcctgt tcctctgctt gtcaaaacgc 1999621 ttctcaatca gcgcttgtac actggtgata ggctcgccgt gaccaggaaa tacgattgtt 1999681 ggatcaagtt gagacagcct tcgcaatgac cgctgataat ccactaaagg ctttgacctg 1999741 acgtctcccg ctttcggcgc ttccaaaatc ggattagacg agctgtttgc cagcagtaga 1999801 tcgccgccaa gcatccttcc gcttttttca tggaacagaa caatatgcga ttcagcatgt 1999861 ccaggcatct ccaacacaga ccagccctca agcccatcta tgcccatacc ttctctgatt 1999921 gattttgtca gagatctcgt acaggaaaat gcgtacgctg atcgaatcag cttttccgcc 1999981 ttccccgtat caaatggaac gcctaattca ggcagcagct tttgaaaaaa acgtttttgc 2000041 caatccataa aggcttgatt ttggctgata taaggttcgt tgaatgtatg cccaatcact 2000101 tcgatttcat ctgaaaagac atcaagcaag cctgcatgat cagcatgatg gtgagtcagt 2000161 acaacctgct cgatatctga caatttcaca tttacagcgg caagctgctc ttgtaaggct 2000221 ctggcagcct cttttgtatt cggcccggca tcgataagtg tcagcgcatc accttttacg 2000281 aggtaaacga taacatcgcc gacagcaaac ggtgtcggga cgcggatcgc aattacatct 2000341 tcagttgtca tcctttcgct ccttgtcttc attcattatt catattttag ctttttctcg 2000401 gtcttgtgtc attattgcag aatgagaaca aacctttttg aaaaagctat tgacattagc 2000461 ttgtccgcca ttgcataatg aacaacaaac taaaacgaga accattggaa cgctatgacg 2000521 aggaatagta tacaaggcaa tggcctaaga gagcgatacc cccggctgaa aggtgttgcg 2000581 gcccgcttgt ttgtagaacc tgccctcaag tcgcggttag gaaaacctaa acgtttcccg 2000641 cgttacgggg atttgagctg agcacaattt gtgctaatga gggtggtacc gcgaaccttt 2000701 tcgtccttta cgtgatgaaa aggttttttg ttgttctaat agaaggagga tatcaatgaa 2000761 aaagatagga tttgtcggcg ccgggtcaat ggcagaagca atgatcaacg gcattttgca 2000821 aagcggcatc acaaaaccag aacatatcta tattacaaat cgctcaaatg acgagcgtct 2000881 gattgaatta aaggaaacgt acagcgtgcg tccatgcaga gataaaaatg agtttttcac 2000941 tcacaccgat atcattatcc tcgctttcaa accgaaagac gcggcggaaa gcatcgacag 2001001 catccggccg tatatcaagg accagcttgt catttcagta cttgcaggcc ttaccatcga 2001061 aaccattcag cattattttg gcagaaagct cgcggtcatt cgcgtcatgc ctaatacatc 2001121 agcggcaatc agaaaatcag caaccggatt ttccgtaagc acggaagcaa gcaagaatga 2001181 tattattgcc gcaaaagctc tattggaaac aatcggtgat gcaacactgg ttgaggagcg 2001241 gcatcttgac gctgtcactg caatcgcagg cagcggcccg gcctatgtgt atcgttatat 2001301 tgaggcgatg gaaaaagcag cacaaaaagt aggattagat aaagaaacgg caaaagcact 2001361 cattttgcag acaatggcag gggcaacaga tatgctcctc caaagcggca aacagccgga 2001421 aaagctgcgt aaagaaatca ccagtcctgg gggcactaca gaggcaggtc ttcgcgcttt 2001481 acaggactcc cgctttgaag aagcaattat tcactgtatt gaagaaacag ctaaacggag 2001541 cgcagaaatc aaagaacagt ttgccggtgc cgccttagag agacattctt agatgtaagg 2001601 acaaaaacag aaggcacagt gccttctgtt ttttattttt cccgcagcag ctggccggca 2001661 gattctgatt gctttaatag cgcggagatc gtaaatgaaa gcaaatcggg aagcacttca 2001721 aaggaataag gcatatacaa tctttccgtc catttatgcg ggtctttacc agccggaccg 2001781 acatttaaaa ctgggacata taaagcctga tttttaccgc ttggcaatga ataccctctg 2001841 ttaaagagcg gcatattgct tgtgtatgca tcaacctcct gtttttccag ctgaagataa 2001901 ctcaagtccg aaagtccggg gaagtactga acctcccgta atgcaatgcc gtatcgctca 2001961 gccgcataat gctttatctg atctgctgta tttctgatca attgatcatc ctttgaagaa 2002021 acagctggat aaagcggcgg actataaaac agaacgatga gcggcgcatc ctccttacaa 2002081 agcgaagcaa gctcagaaac aattttcgtc gaaaaatccc tgtctccaag ctcccccctg 2002141 ttagcaaagg cataatttag agcccgctct gtttccgaga tccccgcacg cttttttgca 2002201 cgcgagacca gctcatcaaa tgtcaaaaca gtgacgtccc gctcaatcgg ctgaaatggc 2002261 tcaaattgtt gaaaatcctg tgttttcttc cgaacgttcg acatgatttc ctccgccgcc 2002321 tgttctgctg ttttaagcag catctgatgc agctcactag ctgagcgttt cattgacagc 2002381 acattaaata atgtgacggc tgtatgcggt gtctggactg aatatgcctc tttcaagtcc 2002441 ttttgcatta agtttaccgg cggcggagtg acctcgccat caaccttttc gcaataatca 2002501 gcattcagtt caagcaaacg gttaatctca gataccatta aatttgcgtt tagacctgaa 2002561 aacggctctc caacatgtgt ctcaatcccc ttgcagaaaa aacccgcaag caccttgcca 2002621 atgcttcctg tataaaaata ttgctgctga tcgccgggaa atttttcaaa catcggttcg 2002681 gcattcaggc aagcggttaa tgtgatatca tgctttttct ccatctcctt caatgcagga 2002741 accgcttcaa tcatgcctct tgaattcact tcctcgtccg gaaccgttat caacagcaga 2002801 ttgccctcaa aatgcccgtt cattgccctc tccagcatcg acagttgaat acaaagcccc 2002861 gctttcatat ccatcgtccc tcttccgaac agccagtctc cgctttcggc atctcttctc 2002921 acacgttccg ggagcagctc ttttttctct aaaaaggagc tcaaaagctc agcaggcttg 2002981 caagccatat gtttaaattc gccgtaatct tctatgtcaa cgacatcaaa atgactcagc 2003041 agaagcactg tctttttgac attcttcttt ttgactagag ccgtaagaaa agatctgcca 2003101 tcgtccatcg gatgaagtgt tacatcatca gggtgctttt gaaaataggg cttgtccttc 2003161 aaaataaaat aaagatactc tgcaagcgct acctcgccct ttgaaccggt gatgctttcg 2003221 tattgcacaa gagaagttaa aagtgccagc aattcgtcct tcgtctgcca attcattgat 2003281 tccgcccctc ctatgaataa aaatgcttct atactgaaaa ataaactgat ttctcgtcta 2003341 ttatacagaa atgtttgaca aaagcggttc atttgagcag tttatatgac gggaaagaaa 2003401 tgacttgata taatcaatct ctaaaaacct tacgggaggc gaaagaaatg gccagaaaat 2003461 tatttacacc tattacaatt aaagatatga cgttaaaaaa ccgcattgtc atgtcgccaa 2003521 tgtgcatgta ttcttctcat gaaaaggacg gaaaattaac accgttccac atggcacatt 2003581 acatatcgcg cgcaatcggc caggtcggac tgattattgt agaggcgtca gcggttaacc 2003641 ctcaaggacg aatcactgac caagacttag gcatttggag cgacgagcat attgaaggct 2003701 ttgcaaaact gactgagcag gtcaaagaac aaggttcaaa aatcggcatt cagcttgccc 2003761 atgccggacg taaagctgag cttgaaggag atatcttcgc tccatcggcg attgcgtttg 2003821 acgaacaatc agcaacacct gtagaaatgt cagcagaaaa agtaaaagaa acggtccagg 2003881 agttcaagca agcggctgcc cgcgcaaaag aagccggctt tgatgtgatt gaaattcatg 2003941 cggcgcacgg atatttaatt catgaatttt tgtctccgct ttccaaccat cgaacagatg 2004001 aatatggcgg ctcacctgaa aaccgctatc gtttcttgag agagatcatt gatgaagtca 2004061 aacaagtatg ggacggtcct ttatttgtcc gtgtatctgc ttctgactac actgataaag 2004121 gcttagacat tgccgatcac atcggttttg caaaatggat gaaggagcag ggtgttgact 2004181 taattgactg cagctcaggc gcccttgttc acgcagacat taacgtattc cctggctatc 2004241 aggtcagctt cgctgagaaa atccgtgaac aggcggacat ggctactggt gccgtcggca 2004301 tgattacaga cggttcaatg gctgaagaaa ttctgcaaaa cggacgtgcc gacctcatct 2004361 ttatcggcag agagcttttg cgggatccat tttttgcaag aactgctgcg aaacagctca 2004421 atacagagat tccggcccct gttcaatacg aaagaggctg gtaatgccca taagagatat 2004481 cctgtagagg atatctcttt ttttattttt agagaaacga tcggctaagg ttctccgtct 2004541 ccctagtaga accaattaga ggagatgact ccaatgaaat cagcttggat ggaaaagaca 2004601 tatacaattg acggatgtgc gtttcataca cagcaccgga aaggatcaag cggtgtaacg 2004661 attgtctttg aggccggcta tggtacttct tctgagacgt ggaaaccatt aatggcggac 2004721 attgatgatg aatttggcat tttcacatat gatcgggcag gcataggaaa aagcgggcaa 2004781 agcagagcta aacgaacagc tgatcaacaa gtgaaagaat tggagagttt gcttaaagca 2004841 gctgatgtaa aacctcctta tttggctgtt tcacactcat acggagctgt catcaccggt 2004901 ttatgggcct gcaaaaacaa gcatgatatt atcggcatgg tccttcttga cccagcttta 2004961 ggcgattgcg ccagctttac ctttataccc gaagaaatgc acaaatcaca tacgagaaag 2005021 atgatgcttg agggcacaca tgcagagttt tcaaaaagtc tgcaggagct caaaaagcgg 2005081 caagtccact taggaaacat gcctcttctt gtgttgtcat caggagaacg gactgagaaa 2005141 ttcgctgctg aacaggagtg gcaaaacttg cacagcagca tattgtctct atctaaccaa 2005201 agcggctgga ttcaagctaa aaacagctcc cacaacatcc atcatgatga acctcatatc 2005261 gttcacttgg ctatttatga cgtatggtgc gcagcgtgcc agcaggccgc tcctctttac 2005321 caggcagtca attaacgtaa aaaaagaccg ggccgtaagg gattcccggt cttttatatt 2005381 attttgtttc acggtgaagg gtatatttct ttaaacgcgg tgaatatttt ttcagctcca 2005441 aacggtctgg attggtgcgt ttattttttg ttgtgatgta atttcggtct cccgtttcag 2005501 tgcaaagcta aagtaacatt tactctcata attaacatct ccttataaaa cgtaatgatt 2005561 acgttttatt atacaacgtc atcacaaatt gtcaaataag agctccgcct tcagcctcgc 2005621 gggacgttta cctctaagaa atcatatgcc gccacgctat tggggaaaac gtcaaccgct 2005681 tctttttgaa gctccaaaga agcatctccc tgatatcttg cgctgatatg ggttaaaatg 2005741 agctgcttcg ctcttgcttc tttcgctgtt acagccgctt gttccgttgt actgtgataa 2005801 taatcataag caagtttacg gtcttcctta gcaaaggttg cttcatgaac aagcacatca 2005861 caatccctcg caagctcttt tagtttgtca cttactctcg tatcaccgga gaacacaaca 2005921 gatcttccct ttttaggagg ctccagaaaa tcattcccat tgatgattcg tccgtcttca 2005981 agcgttaccg tttcgccttt tttgattttc tgatatacag gtccgggcgg gatgttcatt 2006041 tcttttaata cgtcagcctt caaggaaccc ggtacgtctt tttcctgcac acggtacccg 2006101 aaggcttcca ctccatgaat aacagatacc gctgtgacaa taaactgatc gtcctcaaac 2006161 acgattcctt cttcaatttc ctggatcgca agcggatatg tcaaatgggt tttcgtgacg 2006221 gcaaggcttg tttcaataaa cgccttgatc cctttaggtc cgtacactgt cagctcgtcc 2006281 tctccgcctt gaaaggaacg gctccccaga agccccggaa gtccgtatac atgatcgccg 2006341 tgcatgtgtg taataaagat tttctctatt ttacgaggtt taatcgttgt atgtaaaatt 2006401 tgatgctgtg tggcttcccc gcagtcaaaa agccataccg aacgcctttc ttcaagcaat 2006461 tttaatgcca ccgacgttac atttctcgcc ttggcgggga tgccggctcc cgtccctaaa 2006521 aaaagtaatt ccacgtttcc ttcctcctac tagaaccaga tacctacaag aatacaggat 2006581 caagcggaaa atgtgaatct tgcctctgaa aagaacaatc ctttcgtgct agaaacattt 2006641 tttcagcatt ctgcttaaaa aagggcttaa atgtttgctt tcgttgaatt ttagatttaa 2006701 aatgaaggaa atatacgggg tgtactaaaa taaagcttcg aataaagtga ggtactttta 2006761 gtgaaaacaa accaacaacc aaaagcagta attgtcatat tcggtgcaac tggagattta 2006821 gcaaaacgaa aattgtatcc gtctattcac cgtttatatc aaaacggaca aatcggagaa 2006881 gagtttgcag tggtaggagt tggaagaaga ccttggtcta atgaggatct tcgccaaact 2006941 gttaaaacat ccatttcctc atctgcagat aagcatatag atgatttcac gtctcatttt 2007001 tactatcacc cgtttgacgt gacaaaccct ggttcttatc aagagctaaa cgtattgctt 2007061 aaccagctgg aagatacata tcaaattcct aacaacagaa tgttctactt ggcaatggct 2007121 cctgaattct tcggaacgat tgcaaaaaca ttaaaatcag agggtgtaac agctacaacc 2007181 ggctggtccc gccttgtcat cgaaaaaccg ttcggccatg atctgccaag cgcacaggca 2007241 ttgaataaag aaatccgcga agcatttacg gaagatcaaa tttacagaat cgaccattat 2007301 ctaggcaaac aaatggttca gaacattgaa gtgattcgat ttgccaatgc gattttcgaa 2007361 ccgctttgga caaaccgcta catttcaaac attcaaatca catctagcga atcactaggc 2007421 gttgaagacc gcgcaagata ttacgaaaaa tcaggcgccc ttcgcgacat ggtgcaaaac 2007481 catattatgc agatggttgc ccttcttgca atggagccgc ctatcaaatt gaacacagaa 2007541 gaaatccgca gcgagaaagt gaaggtgctg agagcactgc gtcctattgc aaaagacgaa 2007601 gtggatgaat actttgtgcg cggacaatat catgctggtg aaattgacgg tgtaccggtt 2007661 cctgcttata cagatgaaga taatgtcgct cctgactcca atacagaaac ctttgttgcc 2007721 ggcaagctct tgatcgacaa cttcagatgg gctggtgttc cattctacat cagaaccgga 2007781 aaacgaatga aagaaaagtc cacaaaaatt gtcgttcaat ttaaggacat tccgatgaac 2007841 ctgtactacg gtaatgaaaa caacatgaat ccgaacttgc ttgtcattca tattcagcct 2007901 gacgaaggca ttacgcttta cttaaatgct aaaaagcttg gcggagcagc acacgcacag 2007961 ccaatcaaac tcgattattg cagcaattgc aatgacgagt tgaacacccc tgaagcatat 2008021 gaaaaactaa ttcacgactg tcttcttggc gatgcaacaa actttgcaca ctgggatgaa 2008081 gttgcccttt cttggagctt tgtcgactct atttctgaaa catgggcagc aaacaaaacc 2008141 ttatctccta actacgaatc aggctcaatg ggaccgaaag aatctgatga tcttttggtg 2008201 aaagacggct tacactggtg gaacatataa taagaagaaa aaagccgaaa atgtttacaa 2008261 gcattttcgg cttttttacg ctgaacaaag gtataacaat ctccttaata acaaaacccc 2008321 caaagcttaa gagcttcggg ggtttctatt gattacttca tccattcagt atggaagatg 2008381 ccttctttgt cagtacgctc ataagtatga gcgccaaagt agtcgcgctg tgcttggatt 2008441 aagtttgcag gcagtacggc tgtgcggtag ctgtcatagt aggctaatgc gcttgagaat 2008501 gatggcaccg gcacaccttg ggcaactgca agtgaaatca cttggcgaag cgctccttga 2008561 tagctttcta caatattctt gaaatagctg tcaagaagca ggttgtcaag ctcaggctcg 2008621 cgatcgtaag cttctttgat cttctgaagg aatgccgcgc gaatgatgca accaccgcgg 2008681 aagatcatag cgatttcacc atatttcaga tcccagttgt attcttcaga agcagctttc 2008741 atttgggcaa atccttgcgc gtatgaacag attttactca tgaacaacgc ttttctgacc 2008801 gcttcaatca gctcttcttt attttctgta acaggcttca cttctggtcc tgaaagaagt 2008861 ccgctcgctt ttacacgctc ttccttcata gctgagataa agcgtgcgaa tacagattca 2008921 gtaataatcg gaagcggaac gcctaagtca agtgcgcttt ggcttgtcca ttttcctgtt 2008981 cctttttggc ctgctttatc aagaatcaca tcaacaagcg gtttgcctgt ttcttcgtct 2009041 ttttttgtga agatgtcagc cgtaatctca atcaggtagc tatcaagctc acctttattc 2009101 cattcagcga aaacttcatg aagctcatca gcagaaaggc ccagcacctg tttcagaatg 2009161 aaatatgatt cagagatcag ctgcatatct ccgtattcaa ttccgttgtg caccattttt 2009221 acgtaatggc cggcgccgtc cggaccgata tatgtcgtac aaggttctcc gtcaactttt 2009281 gcagaaatgg cttcaagaat cggttttaca agctcatgtg cttctttttg tccgccaggc 2009341 atgatagaag gtcctttaag cgctccttct tctccgccgg aaacgcctgt tccgataaaa 2009401 tgaatgccgc tttcagcgag ttctttgtta cggcgctgtg tatctttata gtatgtatta 2009461 ccgccgtcaa ttaaaatatc atccttctct agatgaggaa gaagagattg aattgtcgca 2009521 tctgttgcag ttcccgcttt aaccattaat aagattttgc gcggtgtttc caaggattgg 2009581 acaaattctt caatgctgta agtgccaaca acattttttc cttttgcctc ctgtaaaaac 2009641 tcctcagttt tactgcttga tctgttgtaa acagaaacag aaaatccccg gctttcgata 2009701 tttaaagcca gatttttacc catgaccgca agtccgataa cgccgatttg ttgttttgac 2009761 atattctaac gtcccttctg caaacgttta atcattttaa aatttaaatt aaaataaaat 2009821 gatatttata ataaagaaat taccatacat tcaccctttt tttcaagcga ttcagctttt 2009881 cttttcatct tgaaaaaaat ctttattaaa gcttgttccc tttgttttgc tctcctcttt 2009941 ttttaacgtt gccccttttc tgatcagttt ggtaccgtac tttttattca gcttttccat 2010001 catctgctga atgggctcat ccttcgcatc ttcattaaag ctgaacaaat cgagctgttt 2010061 ataggcctgc tctttttcta ctaaatccgt tccggtaatg ccaagcagcc tgacaggatt 2010121 tttattccaa tgtttaaaaa agaggtgctc cgcttctttc aaaatgtcat ttttttgatc 2010181 aatcgggttt ctcagcgtag tgcttcttgt gatggttctc caatccgcat atctaatcat 2010241 aataaaaagc ttcgaagcca tgacttcctt gcgctgtaaa cggtcactca cagaagcggc 2010301 aagctttcta aaaacgccta acagctcttc ttcatcactg gaatcatggg aaagtgtcga 2010361 tgagttgccg acgcttttaa attcgtaaat gcgctccggg tcaaccggcg catggtgaat 2010421 gccatttgct ttatttttaa ggcgcggacc gttgatgcca agcaggcgct tcagcgagtg 2010481 ttcatcagct gcagctagct ctccgattgt atggatgccg agtcccttca gtttttccgc 2010541 tgtctttttg ccgactccgt gcatctctcc aacaggaagc ggccacagga tatcgggcac 2010601 ttgcctcttt cttaagatcg taattccaag cggttttttc atatcagacg ccatcttagc 2010661 gagaaattta ttcggtgcaa tccctatgct tgacgggagc agcagctctt tttgcagcct 2010721 gctttggatt tcttttgccg tctctagagc gcggctgctg tatggtgtat cggtcatgtc 2010781 catatagcct tcgtcgatgg agacaggctc cactaggtca gtatattcac gaagaatggt 2010841 aaacatcgct cgtgaagagt ttctatagcg gtcaaagttc ggcggaagaa cgatgagctc 2010901 aggacaatgg cgcttcgctt gccaaaccgg catcgttgtt ttgacgccgc gcgctcttgc 2010961 ttcgtagctg catgttacca caatgccctt tcgctccttt acgtttccgg caactgcgac 2011021 cggctttccc cggagagccg gatcatatgc catttcaacc gacgcataaa agctattcat 2011081 atcaatatgg aaaataattc ggctctttcc cggcataaac aaatctcctt ttcggtcatt 2011141 agacaacagc ttgtacatat agtaaaatga agctattgaa tggatgtgat gacaatgttt 2011201 gtggaatcga taaatgacgt tttattctta gtcgattttt tcacaattat tcttcctgct 2011261 ctaacggcaa tcgggattgc attcctctta cgggagtgcc gtgcgggcga gcaatggaaa 2011321 tcaaaacgaa cagatgaaca tcagacggtc tttcacatta accgaacaga ctttcttatt 2011381 attatatatc atcgcattac aacttggata cgtaaagtct tccgcatgaa ttcgcctgtg 2011441 aacgatgagg aagacgccgg ttctcttctt ttataaaccg catttataaa aaggaggaga 2011501 acaaaattgt taaaaacata tcaaaaactt ttggctatgg gtatcttttt gatcgtatta 2011561 tgctcgggca atgctgcatt tgcagcgact aatcaggtgg gaggcctcag caacgtaggt 2011621 tttttccacg attatttaat cgaaccgttt tccgctctgc ttaagggtgt tgccgggctg 2011681 tttcacggag aatacggact ctctattatc ctcgtaacca ttattgtgcg tatagttgta 2011741 ttgcctttgt ttgtcaatca gttcaaaaaa cagcgcatct tccaagagaa aatggccgtt 2011801 attaaacctc aggttgacag tatccaggtt aagttgaaaa agacgaagga cccggaaaag 2011861 caaaaagagc tgcaaatgga aatgatgaag ctgtatcagg agcataatat caacccgctt 2011921 gcgatgggct gtcttccaat gctgattcag tctccgatta tgattgggct ttattacgcg 2011981 attcgctcaa cacctgaaat tgcgtcacac tcgtttctat ggttcagttt agggcaatct 2012041 gatattctca tgtcccttag tgcagggatt atgtattttg tccaagccta tatcgctcaa 2012101 aaactgagcg cgaaatattc cgctgtcccg caaaaccctg cagcgcagca atccgcaaaa 2012161 ttgatggtgt tcatcttccc tgtgatgatg acgattttct cgcttaatgt gccggcagcc 2012221 cttccgctgt actggtttac aagcggactg tttttgacag tgcaaaacat cgtccttcag 2012281 atgacgcatc ataaaagtaa aaaaacagcc gctcttactg agtcggtgaa ataaaaaagc 2012341 aaccccgtgc aaaaagccgg ggttgttttt tgttacttgc aaagtaccgc gccaaacagt 2012401 cttgtttatc atggctgaag cagaaatggc catcctaaaa aatagccgta tcgtttaaaa 2012461 agaaggaaat cgggaatacc tttactcacc tccaaccgaa aggagcctat acgttgacgg 2012521 aacgctttca gcaaaaaaat atttctgtac ctgatggaat ctggatcatg agacaaacct 2012581 ggaatgatgt cttatttgct cactggcctg ttgatgtttc tatccttcgc gctttggtac 2012641 cgtccgtttt agaattagat acatataacg ggcaagcttg gatcagcatg cttcccttta 2012701 tgctcacgaa cctgagggcg cgttatctcc ctgtcattcc cggtgcgcgt gcatttcctg 2012761 agcttaacct ccgcacctat gtcacgtata aaggcaagcc cggcatttat ttttttagct 2012821 tagatgccga tcatcgtctg gcggtccttg gcgctcgcac attctttcat ctgccttatt 2012881 tttacgcgga tatgaagtcc gaaaaaaacg gtgatgccat tgactatgtc agcaagcgga 2012941 aaaatgacaa agaagcagca ttccacgccg cataccggcc aatttcagcg ccttttacag 2013001 cagaaaagga ttcgctcgat tactggctga cagaacgata caggctctac accacttatc 2013061 gcaataagct ctattacgaa gacatccatc atcatccgtg gctgctgcaa aacgccgaag 2013121 cagaaatttc agtcaatacg gtgactgatg ctcacggtat tacattgccg gagtcagacc 2013181 ccttgcttca ttatgctaaa aaacaggatg tgttattttg gccgcttagg aaatggagct 2013241 aaaaaaaccc gatgcgggaa atcgcactcg ggttttcttt ttttattttg ccgcctcttc 2013301 aataatggca acaaccattt ctgccgtttt aacgagctct tcgatcggca ttttttcatt 2013361 ttttgtatgg atttgctcat aaccgacagc aagattgacc gtcgggatgc catgaccagc 2013421 gattacgttc gcgtcgcttc cgccgccgct cgtttgcagc tcgcttggac gtccgatttt 2013481 agcagccgct tttttcgcga tttcaacaac ttggtcgccg tcttgatatt taaagcccgg 2013541 atacataacc tcaatttcga cttctgcgcg tccgcccata tcagcagctg cctcttcaaa 2013601 agcagctttc attttttgaa cctgagcttc cattttctca ggaactaaag agcgcgcttc 2013661 agcaagaata tgaacttcgt cgcacacaat gtttgtttgt gtgccgcctt caaaccggcc 2013721 gatattagct gttgtttctt catcgatacg gcccaatggc atttttgaga tggctttgct 2013781 agcgattgta atcgctgaaa tgcctttttc aggttcaacc ccggcgtgag cggttttccc 2013841 gaaaattgcc gctcttacct tcgcctgtgt cggcgcggcc acaatgatat ttccgacttt 2013901 tccgtctgaa tcaagagcat agccgtagga tgcagtgatc atagaacggt caagcgcctt 2013961 cgctccgatc agacccgatt cttcccctac tgtgatgatg aattcaatcg tgccgtgttc 2014021 aatattttct tctttcagca ccttaatcgc ctcaaacatt gcagccaatc ccgctttatc 2014081 atcagcacct aaaatcgtcg tgccgtcagt tttgacgtaa ccgttctcta caactggttt 2014141 tacgccgttt ccgggtacaa ctgtgtccat atgagatgta aaatagatcg tatctgtttg 2014201 ttttgtccct tttagcgtgc aaatcaggtt accggctccg tggcccgtga tatccattgt 2014261 atcgtcttct ttaacgtcca cacctaaatc agaaaatttt cgtttcagca ctttgcagat 2014321 ttcagcttcg tgctttgttt ctgagtcaat ttggacaagc tctaaaaatt cttccagcag 2014381 gcgtttttca ttcaccattt gtaagtccct ccatattaaa gcggtatgtt accgtgcttt 2014441 tttttcggtc tctcttctgt cttatgtgta agcatatgaa aagcttgaat cagtcttccc 2014501 cttgattctt ccggcaaaat gatgtcatcg accattccac aagcggccgc tttgtatggg 2014561 ccggcgtttt gctttttgta ttcagcagtt ttttcgcgtt tcgtcttttg cgggtcagct 2014621 gaagctttga tttccttttc atacaaaatc gatgccgcac cttctggacc catcactgcg 2014681 atttcagcat tcggccatgc aaacacaagg tccgctccga tcgctttgct gttcatggcc 2014741 acataggcgc cgccgtacgc ttttctaatg atgagtgtga cttttgggac agtcgcttca 2014801 gcataagcaa acaataattt tgctccatgc ctgatgattc cgttgtgctc ttgctgaata 2014861 cccggcagaa accccgggac atcttcgaca gtcaacagcg ggatatcaaa tgcgtcacaa 2014921 aaacggatga accttgctgc tttatcagca gcgtcaatcg tcaggcttcc cgccagatgc 2014981 ttcggctggc tcgccacgat gccgattgct ttttcaccca gccttgcaaa cccaatgaca 2015041 atgttcttcg caaaaaatgg ctgaatctca aaaaaagact gcgggtcagc cagctcccta 2015101 atcaccttcc gaacatcata aggctttgtc gtatcagcag ggacaagacg gtttaataac 2015161 ggtctggacg cctctttctc tggcttcggc tctgttgtcc ggccattcag cggcaaataa 2015221 gacagtagtt ttctcacccc tgtcagaacc tccttctccg tatgcccgga aaagtgggcg 2015281 tttccgctga cggcattatg tatccccgct ccgcctaagc tctccgcatc aacctgttcc 2015341 cctgtcactt tttcaatcac cttcgggccg gtaataaaca tccggccagt ctgttcagcc 2015401 ataaatataa aatctgtgag tgccggagaa tatacagcgc ctccagcgca cggccctaaa 2015461 ataaccgata tttgcggaat gactccggaa tataagacgt ttcggtaaaa tatgtgaccg 2015521 tatccatcta atgataacac accctcttga attctcgcac cacctgagtc attcagcccg 2015581 ataatcggcg ccttattttt tgctgccaga tccatcaaag cgcagatttt cctggcatgg 2015641 gtttcgccaa gcgcccctcc gtacactgtg aagtcttgcg caaatacata aactgagcga 2015701 ccgtcaattg tgccgtaccc tgtcacgacc ccatccccta acatgcgctg ttctcttgtt 2015761 aacacttgac tttccatgaa ggggtgtaat tcgataaagc tgtcctgatc tagaagaaat 2015821 atgatccttt cccgagcagt gagcttgccc ttttgccgct gctgagccag cttttcccgt 2015881 cctccgcctt cttctgcctg cttgcgtttc gtgtaaaaat gatccatgtg ctcattcatg 2015941 ctcattgtgt tggtctcctt tcggttcaca aagctctaca agaacaccgt ttgtttcccg 2016001 aggggaaata aacgcgatct ttttcccgtt cgctccctgt cttggaaacc tgtcaatcaa 2016061 ttgaacatgc tgatcagaca atgcttgaag ctgttcagat aggcagttgc acaaaaacgc 2016121 aatatgatgc agtccctgcc ctttcttctc caaaaataaa tggacggggc tgtcagctgt 2016181 caacggctct atcagctcaa gtttgacgct accagcttga aaaaaagcaa cattcacctt 2016241 ttgctcttca accgtttctt gatgaagaaa tgcaagcccc aatacatttt cataaaagct 2016301 tcttgcatct tttatcgaaa aaacggctat cccgatatgg tcaagcctgt tcattttcat 2016361 ccctgctttc gctaatagat atcgcttgtc cgcccattca aaacacgcta aaatatagac 2016421 agattgttta aggagtgaaa atcatgtctc aaaaactgat gaaaagcgtt ttgatcgtga 2016481 ttttgggagt ttttattctt tcaactgtac tctcaggaat cgtcatgttt ctataacgat 2016541 aaaaaagcag gcgccttatt caatgggaat atcctgcttt tttatcagag ctttatgctc 2016601 gatggcaatc tcctcaaaag agcggttgtc gtccgtgatc agcactctcg ttcctactgg 2016661 tatcgtttga aacaaatgaa caacctcatc gttatgcata cgtatacagc cgttagacac 2016721 aaattttcct actgattcct ctcggtttgt cccatgaatt ccataaatcc gcccgtccgt 2016781 tcctttcgcg tcaaatccga tccatcttgc cccaagcggg ttatcaggag atcccccttc 2016841 aatatttttc tttctgtagt aaggattttc cgcttttacc gttaccgaaa actctccttc 2016901 aggcgtcaaa tcatctgttt ttccagtcgc cacactatac acgccttcta ctttgttgtc 2016961 gaggataaca gcaagttcat ttgttcgctt gttgacaata acatacggat cacccggcag 2017021 cggattttcg ccgagcggcc aaatcggtga aatcatcatg aaaatcgaac ataagaaaaa 2017081 acgcataagc tcctcctttt tcattaggtt gaccaatgaa ggaagagctc atgcgaatca 2017141 tccgagtgat ttttgcgctt ttattccttt aaaataactt ttaatcacta aatattgttc 2017201 catttcgccg agaagatgga agagagcggc cctcgcttca aattcctctc tagtcgcagg 2017261 aagcggcatc tcctcaaatt cttttctcat gtcagcaagt cttttcagaa atttgtatgc 2017321 tgtattccca gggtgtatcg cctcccgcaa atcatgaata aattcagcga tcatttttcc 2017381 ctgatctacc gtgatggaga tcgatgtcac tttagggaga aggcgttcga taatttcaaa 2017441 ttgcttttct ctcattttaa aataatgata atgcagattt tcataacgca aaatgtggtt 2017501 ttgcacatct cgatatgcca ggtttttagc ctccgtaatg agctggtgcg tttccggaat 2017561 ttcttttcct gaccaatctt gctcaccagt taacaaatac cgttcgattt ctgcaaaaat 2017621 gacagcaaag ttatcctcta tctttttgcg gtaggcaatc agtttccggt caagactagg 2017681 catatacaag ttcatcaata gagcgacgcc gatgccaacc gtaatcagct gaacttcatt 2017741 ccagatgaaa gtaggcgtaa tgccgccgga catgtataaa tgaaggataa taacagaact 2017801 ggtgacgata ccctcgttaa tttttaacag aaccgttatc ggaatgaata tcaaaagaag 2017861 cgctccgatc acaaacgggt ggtagccaat aagctcgaaa aagagataag aaaaagcaat 2017921 tgccagacag catgccgaaa agcgggccca tgaggcctga agcgaccgtt tttgtgtgat 2017981 ttgtatgcac aaaatggtga tgattcctgc tgatgcgaag ttttgcaaat gcaataactg 2018041 gcttatataa atagccaaag ctgttccaag cgcggtcttt attgtgcggt aaccaatttt 2018101 aaacatgtcg gactccattt ctatttgttt cttcaataaa aaagaagagg cggccagcct 2018161 tcttcttttt tatattctat aatattttct ctaaaaagtc ctgcgctctt ttggattttg 2018221 gcgacataaa aaattccttc ggattgccgt cttcgacaat cattccttgg tccataaaca 2018281 gcacacggtc tgccacttct tttgcgaagc ccatttcatg tgtgacaatc accatggtca 2018341 tgccggtttc gaccagctct ttcatcacct gtagcacttc tttgaccatc tctggatcaa 2018401 gggcggaggt cggctcgtca aacagcatga tgtccggatt catcgcaaga gccctggcaa 2018461 tcgcgacacg ctgtttttgt ccgccagaca aacggtttgg atagtcattt cgcttttcaa 2018521 acaaaccgac tttgcggagc aggtcctcag ctttctcctg tgcagcctgt tttgattctt 2018581 tttttacatt gacaggcgcg tacatgatgt tttcgagaac cgttttgtgc ggaaagagat 2018641 gaaaatgctg aaaaaccatc ccgatgtttt cccggacctt taatgtgttg gttttcggct 2018701 tcgtaatctc tgtgtctttt attgtaatgg ttccgccgtt aggcttttcc aacaggttta 2018761 aacagcgtaa gaacgttgat ttgcctgagc ctgaaggacc gatcacggca acaacctcac 2018821 cctcagcgat tgttgttgaa atgtttttta atacttcgtg tttcccaaat gattttgaca 2018881 gcttttcaac cttaatcatt ggatttcagc ttcctttcta cagccttgcc gataaacgtt 2018941 aaaatcagga caagcacata ataaatcaat cccgcgataa tgagcggctc aaggtaattg 2019001 taagtggcgg cgccagcttg atatgcgcgt ctcatgacat caccaagccc gatgacggtg 2019061 acgatcgccg attcttttgt taacgtaatt aattcattca caattgcagg tgatatattt 2019121 ttgaaggcct gcggcagcag cagatccttc atcatttttc catacgggac accgagtgca 2019181 acagcagctt ctttttgccc tttatcaatg gcattgattc cggctctgat aatttccgat 2019241 acataagcgg cggaattcaa agacaatgcg acaaccgcag cccaaaactg gtcaatttga 2019301 aatccgagca gctgaggaag gccaaaatag acaatcataa gctgcagcac taaaggcgtg 2019361 cctcggaaca ctgatgtata aaaatcagcg atccagataa acgggcggaa tgtgctgatc 2019421 ttgcataagc ttagcacaat accgagtata agtccgataa tagcagatac aacaacaatt 2019481 tttaatgtaa ttgccaagcc ttctaatata aaaggaattt gggggatcgt tgctgaaaaa 2019541 tccaaattca tagcctttgt ctccttttct tacaggaaaa aagtttccta ttcaataaaa 2019601 aggctcaacg aaaaagttga gccgcttttt tttacttctc gccagtgaac cattttttct 2019661 tcaatttctc aagctctccg ttatcttcca tttccttgag cgctttattg aatttgtctg 2019721 tcagttcact gtcctttctg aaagcaattg ctgaaccggc ttcttccgct ttcgcatcag 2019781 gaatcacaaa gccttgcagg tcatcatttg atttgaaata cccttctgca acaatgtctt 2019841 caataatcgc ggcatcgaag cggtcagatt tgatttcctg caccaaatca gaaattctgt 2019901 tgcggtcttc tgttttaaaa ccatattccg gagaaagctc tttccccttc tcttcctgaa 2019961 tagagccaag ctgaacgcca actgtttttc ctttcaggtc tttcaaagat tgaatgccgc 2020021 tgtctttttt gctgacaatc atatggttcg ctgtgtaata cacatcggaa aaatcaactt 2020081 gttttttacg ctcaggcgtt ggtgtcattc ctgacagaac gagatccacc tgttttgatt 2020141 taagcgctgt aattaagctg ttgaagtcca tatcctgcac ttcaatttca tagcctgcct 2020201 tctttgccag agcttttgcc agctctacat caaagccgac aatattatct ccttctttat 2020261 attcaaacgg tttgtaatcc gccgaagtac ccataattaa ttttttcttt ccgctttctg 2020321 aacctgaatt gcttgagccg cacgcagtta atgcaaaggt gatgcaagca gccacaagta 2020381 ataagagcca ttttttcatg atccatttcc cccgtattca ttacttttgg tgtatttgaa 2020441 tatttattcg ttaatttgta ttttaaacag tttctcattt ttatgcaata ctatttttaa 2020501 aaattatctt taggcttatc tttccagtga tctcttctga tattactaga taaaaattaa 2020561 atcgctgtac aatccgattg aataatccct taatatttat tcatatatcc ttggaaattt 2020621 atgcacaaaa aaacccgggc tgctttgagc atccgggttg ttcgtcttat acttcttcac 2020681 aatattcttc aaaggcttcc tgcagctttg ccactacagc catcggctca tggccttcaa 2020741 tttcatgacg ctctaccatt ttcatgatct ttccgtcttt caaaatcgca aaggacggag 2020801 aagatggtgg ataaccttca aaatagtcac gcgcacgcgc tgtcgcttct ttatcctgtc 2020861 cggcaaaaac ggtgacgagc tgatcaggtc ttttatcata gtgaacggaa tggtaggctg 2020921 ccggtcttgc aattcctccg gcgcatccgc aaacagagtt taccatgacg agcgtcgttc 2020981 cttttttcgt aagtgcctca tccacctctt cggctgtttt aagctcggtg tatccggcag 2021041 ctgttatttc ttgtctcgct tggcggacaa tatcattcat aaataaatta aagtccatgt 2021101 tcaatgaaga cctctccttt ttcatcatct gttcttatga tagcaaggaa acgtccatat 2021161 cggcaaatga ctttgcttcg ccgtgcactt tttttgctct tcgtttactg cttacagaaa 2021221 aaggggatta tataaccaga agtaaaataa aggagcagtt gtatatgagc caccggaaag 2021281 cgttactgat tcataacgga aatgccggca acaaaaatat agaaaaagca cttggtgctg 2021341 tggtgccggt tttatctcac catttagatg aggtgattat taaacagaca aagaaaaagg 2021401 atgatgcgta tcatttttgc cgatccattg atgattctgt cgacaccgtc ttcattctcg 2021461 gcggcgacgg cacgatccat caatgcataa atgctatcag cgctctagaa agaaaacccg 2021521 ctgtcggaat tttgcccggc ggcacgtgca acgacttttc aagagtgctt ggcatccctc 2021581 aaaatcttgc aaaggccgcg gaagcactta tggcgggaaa aaaaaccagc gtagacgtat 2021641 gtcagatgaa tgaccgttat tttttgaatt tctgggggat cggcttaatt gcagaaacgt 2021701 cgaatcaaat caacgaaacg gaaaaagcat tattgggaaa aatcagctat tttacaagtg 2021761 ccttgcgaac cgtctcatct gctgcatcgt ttccgatgac attaaaaatt gatggagaag 2021821 aaattaaaga agaagccgtt atgctgcttg tgatgaatgg ccaatacatt ggaacgaatc 2021881 gaattcctct gcccgatgcc agtattgaag acggcttact tgatgttctc atatgccgca 2021941 ataccaacct caccgcgctg cgggagctga tgagcatgga acaaggctca attgatcgtt 2022001 ttactggaga gttgtcctat gtccaggctt cccgtatcga gattgaaaca gacactgcca 2022061 aaaaggcgga tatggatgga gaagtttata cacatacacc cgcagtcatt caggtcctgc 2022121 cacagcatat cgacatgctt gttcccgcaa atgaataact gtcataaggc tttagaaaga 2022181 ttttgcaaat ccgttgactc tcccctagga ggaggtctta cagtataagg gatacacact 2022241 tgaaaaaggg gaagtcatat ggagaagaaa aatattacct taactatatt attaaccaat 2022301 ttatttattg cttttttggg gatcgggctt gtgattccag taacgccgac cattatgaat 2022361 gaattgcatt tatcggggac cgcggtcggc tatatggttg cctgcttcgc tattacacag 2022421 ctcattgtct caccaatagc cggacgatgg gttgatcgct tcgggcgcaa gatcatgatc 2022481 gtaatcggcc tgttgttctt tagtgtgtcg gagtttttgt tcggcattgg aaaaacagtt 2022541 gagatgttat ttatctcccg tatgctgggc ggtatcagcg cagccttcat tatgcccggg 2022601 gtcacggctt ttattgcaga tatcacgacc attaaaacac ggccaaaagc gctcggttat 2022661 atgtcagccg ctatttcaac aggatttatt atcggccccg gcatcggggg atttttagca 2022721 gaagtccatt cccggctgcc ttttttcttt gcggcagctt ttgcactgtt agcagccatt 2022781 ttatcaatcc tcacgctgcg cgagccggaa cgaaaccctg aaaatcagga aataaaagga 2022841 cagaagacag gctttaaacg aatttttgcc cccatgtatt tcatagcttt tctcattatc 2022901 ttaatttcgt cttttggttt agcatcattt gaatctttat ttgcattatt cgtggatcat 2022961 aaattcggat ttacggccag cgacattgcc attatgatta caggaggagc gattgttggc 2023021 gccattacgc aagtcgtctt attcgaccgc ttcacaagat ggtttggcga aattcattta 2023081 attcggtaca gcttaattct ctcgacgagt ctggtattct tgctgacaac ggtacattca 2023141 tatgttgcga ttctgctggt gacagtcacc gtatttgtcg gatttgatct catgcggcct 2023201 gcggtaacga cttacctgtc aaagattgcg ggaaatgaac aggggtttgc cggcggtatg 2023261 aattcaatgt ttacaagtat cggcaatgta ttcgggccta ttatcggcgg aatgctgttc 2023321 gatatagatg taaactatcc tttctacttt gcaacggtca ccttagccat agggattgca 2023381 ctgaccattg cttggaaagc gcctgcacat cttaaagcca gcacgtgata agaagcgcat 2023441 tctttgtgta ctgcaaagaa tgcgcttctt ctttatactg atgatagaag gagtgatggc 2023501 atgaaggaat cgtattactc aattggggaa gtatcaaaac tggcaaacgt gtcgataaaa 2023561 gcgctccgtt attacgataa aattgattta tttaaaccag cctacgtcga cccggatacc 2023621 agctaccgct attatacaga ttctcagctc attcatctgg atttgatcaa atcattgaaa 2023681 tatatcggca cacctttaga agagatgaaa aaagcacagg acttagagat ggaagaactg 2023741 tttgcttttt atacagagca ggagaggcaa atcagggaga aattagactt tttatcagcc 2023801 ctggagcaaa ccatttcatt ggtgaaaaag cggatgaaac ggcagatgga atatcccgcg 2023861 ctcggtgagg tgtttgtttt agatgaagaa gaaatacgga tcattcagac agaggcagaa 2023921 ggaatcgggc ctgaaaacgt gctcaacgcc tcctacagca aattaaaaaa atttatcgag 2023981 tcagcagatg gatttacgaa caatagctac ggcgctactt tctcttttca gccctacacc 2024041 agcattgatg aaatgactta ccgtcatatt ttcacacctg tattgacgaa taaacagatt 2024101 tcatcaatta cgccggatat ggaaatcaca acgatcccta aagggaggta tgcgtgtatc 2024161 gcgtataatt tttcgcctga acattatttt ctcaacttac agaagcttat caaatatatc 2024221 gcggaccgcc aattaacagt tgtcagtgat gtatacgagt taatcatacc gattcattac 2024281 tccccgaaaa aacaagaaga atatcgagtc gaaatgaaaa tacggatcgc tgaataataa 2024341 agcatagaaa aagagcattt tttgaaacaa aacttcaaaa aatgctcttt ttgcttattt 2024401 agtaaacaga tgtcttctcg tcaatcgatt ctaaaatttg tttcactcgt ccgaggaatc 2024461 gtccgcacac gagaccgtca agcactctgt gatctaatga caggcacaga ttaaccatgt 2024521 ctctgacagc aatcatgcca ttgtccatga caaccgggcg tttgacgatg gattctactt 2024581 gaagaatcgc agcctgaggg tagttgataa tgcccatcga ctgaacagac ccgaacgaac 2024641 ctgtgttgtt gacggtaaac gtgcctccct gcatgtcatc tgcagtgagt tttccgtctc 2024701 ttactttttt agctaggccg gtaatgtctt tcgcaatgcc tttaattgtt ttttcatcag 2024761 cgtttttaat caccggaaca aataaagaat cctctgtggc aactgcaatt gaaatattga 2024821 tatccttttt ctgaataatt ttgtcccccg cccacatgct attcatttgc gggaattctt 2024881 ttaacgcctg agcgaccgct tttacaaaaa aggcgaagaa cgttaaatta aagccttctg 2024941 tcttcttaaa agaatctttt atactgttgc gatatgcaac catatttgtg acgtcgactt 2025001 ccatcatcgt ccaagcatgc ggaatttctg ttttgcttcg cttcatattg gaagcaattg 2025061 cttttcttac acctgtgaca gggatttctt tatcaccggc tgcagacgca ggatatgacg 2025121 tctcttcttt tggctcaggt tttgatgcag acttcggtgc aggagctgct gttttcagct 2025181 cctcaggatt ctgttcttgc acgccgcctg tttcaattaa gcgctgaata tcttttcgtg 2025241 tgatgcgccc gccggcacca gttcctgtca cttgatcgag gtcaatgccg tgctctccgg 2025301 ccaaacggag aacagctggc gagtagcgct ttttattggg ctgatcggct gctccagcac 2025361 tttttgcaac agggttctca gcggcttctg atgctgctgg ctgttcttgt ttttgttcag 2025421 ccggattcgc gccttctgtt tcaattttgc aaatcatttc tccgacttgc agggtttggc 2025481 cttcttctcc cacaagctct gttatcgtac cagtaaaaga agacggaacc tctgcattta 2025541 ccttatctgt catgacttcc gcgatcggat cgtatttgtt cactttatca ccgggggcga 2025601 caagccattt gctgatcgtc ccctctgtta cgctttctcc aagctgcggc atcgtcattt 2025661 gttcaattgc catgattgta tcctccctta cgtctttaaa actccgctaa ttctctcatc 2025721 gccgcttcca ctttatcagg gttgaccata aagtattttt ccattgtcgg cgcataaggc 2025781 atagccggaa tatcaggacc tgcaagccgt ttgatcggcg cgtctaagtc gaacagacaa 2025841 tgctcggata taattgcggc tacttcgctc atgatgctgc cttcttttgt atcttctgtg 2025901 accaaaagaa cctttccagt tttggacgca gcttcgatga tggcttcttt atcaagcggg 2025961 taaactgttc ttaaatccac cacatgcgct gaaatgccat ctttttcgag acgttctgca 2026021 gcttgtaagg cgaagtggac acacaggccg tatgtgatca ctgtgatgtc gtcgccttcc 2026081 ctttttacgt ccgccttgcc gattggcagg acataatcat cagccggaac ctcgcccttt 2026141 atcagacggt atgcccgctt gtgctcaaaa aacagcacgg ggtcttcgtc acgaactgcg 2026201 gcttttaaga gccctttcgc gtcatatggt gttgatggca tgacaatttt cagtccgggc 2026261 tggttggcga aaattgcttc gactgattga gaatgataca gggctccgtg cacgcctccg 2026321 ccgtatggcg ctctgacgac aatcggacag ctccagtcat tgttgctgcg gtagcggatt 2026381 ttagccgctt cagaaataat ttggttgact gccggcataa tgaaatcagc aaactgcatt 2026441 tcagcaatcg gtctcattcc gtacattgcc gctccgatac cgactcctgc gattgcagat 2026501 tcagcaagcg gcgtatccat aacgcgctct tccccaaatt gttcatagag tcccgctgtc 2026561 gctttaaaca caccgccttt tcttcctaca tcttccccaa ggacgaaaac gcgagaatct 2026621 cgttccattt cttctttcat cgccaaattg attgcatcaa tatatgacat tactgacatt 2026681 tgttcttcct ccctacttcg cataaacata atcaagcgct gactcaggag ctgcatatgg 2026741 ggcgttctcc gcttcatccg tcgcttcatt tacgattgcc ataatttcat ccagcatggt 2026801 ttgttctatc tcatcggaca gcaggcctgt ttcctttaag taagcttgat aagtaagcag 2026861 gggatcactt tttttcgctt cctctacttc ttcacggcct ctgtagctgc tgtcatcgtc 2026921 atcactggaa tgtggtgtaa ggcggtaaga aatcgtttca attaatgtcg ggccttctcc 2026981 tctgcgtgcc ctttcgcgtg cttctttaac cgcttgataa acttccagcg gatcatttcc 2027041 attcacagtt acgccaggca tcccatagcc tatggcacgg tcggaaatgt tctcacatgc 2027101 gacttgctta tcgtaaggca ctgagattgc gtatttgttg ttttcacaca tgaaaataac 2027161 cggcagctta tggacagcgg caaagtttgc cccttcatgg aaatcgcctt ggtttgaaga 2027221 cccttccccg aatgtaacaa aggctgcgat atcctttttc tccatacgtc ccgcaagcgc 2027281 aataccgact gcgtgcggca cttgcgttgt aaccggagat gatcccgtca caatgcggtt 2027341 tttcttttgt ccgaaatgtc ccggcatctg gcggcctcct gagttcggat ctgctgcttt 2027401 tgcaaacccg gacatcatta agtcctttgc tgtcatgcca aacgcgagca cgacacccat 2027461 gtctctgtag tacggcaata cataatccat ttcacggtca agtgcgaaag ccgctcctac 2027521 ctgtgctgct tcctgtcctt gacaagagat tacaaatgga attttgccag aacggtttaa 2027581 cagccacatt ctttcatcga tttttcttgc taacagcatg gttctataca tatcaacggc 2027641 ttcctgatca gtcagcccta gtgcttgatg tcggtttgta ctcattcaag cccctccttt 2027701 atgcttttaa aaatgaatgg ctttgccatc tgcggcaagc gcagcttctc caattgcttc 2027761 agaaagcgtt ggatgcgggt gaatcgtttg cccgacctcc cacggtgttg cgtccagcac 2027821 tttggcaaga cccgcttcag aaatcatgtc ggtgacatgc gggccaatca tatgaacgcc 2027881 gagaatatca tctgtatctc ggtcagccac gattttgaca aaaccgtcgc tttcaccgta 2027941 tacaagcgct tttccaatcg ccataaatgg gaacttgccg attttgacat tatgcccgtt 2028001 cgcctttgct tcgtcttcgg ttaagccgac actggcagct tcagggcttg agtaaatgca 2028061 cttcggcaca agcgtcggat caagcggatg cggattgaga cctgcaaaat gctcaacagc 2028121 aataattccc tcatgtgaag caacgtgagc taactgcagg ccaccgatta cgtctccgat 2028181 tgcataaata tgagattcct tcgtttggca gctttcattg actgaaatca tgccattttc 2028241 agtaacaata tcggtgttct ctaggccgat gccttcgata tttgcctgtc tgccgatgga 2028301 aacaagcatt ttctcagcag aataggtaac ggtttctccg tctttttccg cttgtatgct 2028361 gatatcgtct gatgtttttg tcattgtgtc aggcagcact tttgcccctg ttatgaactg 2028421 gatgcctttt ttcttaagaa gactttccat ttcttttgaa atctctagat cttcagtcgg 2028481 caatatgcga tccgcgtatt caataaccgt taccttaacg ccaaaatcat gaagcataga 2028541 cgcccattcg ataccgataa cccctccgcc gacaatgatg attgactgtg gcagctcctc 2028601 catttggagc gcctcatctg aagtcagtac agacttaccg tccacttcaa gacccggaag 2028661 cattctcggt cttgatcctg ttgcaatgat cacttgtttc gggatcagca tgtcattttc 2028721 ttcgccattt ccccgctcaa cagaaattgt tcccggcagc ggagagaaga ttgacggtcc 2028781 aaggatacgt ccatatccgg tgtacacgtc aatttttcct tttttcatta aatgatttac 2028841 acccgctgca agcttatcaa caacggcttg cttacgctgc tgcacttttt caaagttgag 2028901 ggacacgcca gccgtttcca ctccgaattg atcggcttca cgagctgtcc ggtatacctc 2028961 tgcgcttcta agcagcgctt tactcgggat acagccttta tgcagacatg ttcccccgag 2029021 tttttccttt tccacaacgg ctgtttttaa gccgagctga gcggctctga tggccgcaac 2029081 ataaccgccg gtaccgccgc ccagaatgac tacgtcatac tcagttgcca tggtgactca 2029141 ctcctgtctg tctattcaat acgatattgt ttggattgct cttcgccctg caatactctt 2029201 agcgcccctt gggcaagaga ctgcagttca ttttcacccg gataaactaa aacgtctgaa 2029261 atccaatcta tgtatgatct gatagcagaa acaaagcttt ttccgtacgc aaggcctccc 2029321 gtcagcacaa tcgcttcaac ttcgcctttt aacgccgcgc tggctgcccc gatttccttt 2029381 gctacctgat atgccatggc atcataaatg aagcgggctt tttcatcgcc cccttgaatc 2029441 atctgttcca cttttactgc atcatttgta ccgagatagc ctaaaagtcc gccggtgcca 2029501 acaagctttt tcatgatttc ttcttttgta tattcccctg aaaaacatag atcaacaaga 2029561 tctcccgcag gcactgttcc tgctcgttca ggactgaatg gtccctcgcc gtgcaggccg 2029621 ttattgacat ccaccactcg cccgcggtca tggacgccaa ttgtaatacc tccgcccata 2029681 tgggtaataa tcattttcat gttctcatat cgtttgccaa gggaggctgc cgctttacga 2029741 gcgacagctt tttggtttaa cgcatggaaa atgcttttcc tttcaatttc aggcatgcct 2029801 gaaactttcg caagcactga catttcgtct acgacaacag ggtcgacgat atacgaaggg 2029861 atattcaggc cgtcagcgat ttcccgcgcg ataatgccgc cgagattaga agcatgctga 2029921 ccggcgtagc cgcttttcaa atcctcaatc atctcatcat tcactacgta ggtcccgcct 2029981 tcaattggcc ggagaaggcc gcctcttgcg cagactgcat caaactttga aatattgatt 2030041 ccctgttcat gaagcgtttc gagaatatgg tttttacgaa attcatactg atcaataatt 2030101 cggtcaaatc gctgcagctc ttctatgttg tgtctcaatg ttttttcaaa aatgcttctt 2030161 tcgttatgaa aaacaccgat tttcgttgaa gttgagcctg gattaattgt gagaatgcgt 2030221 ttttcgtcat gtagcacttt cataacctcc agatcaattt cttaacgtct gcttaataca 2030281 ctgtggccgt tttgcaaaaa ctggcttctt gagcggcgca tgcgttcaat ccgttcctct 2030341 gctaagcggt cagccgctaa atatgcagga atgccgtcac gctgagaaat ctcaagtaca 2030401 cgctcgatat tgccgtaaat gccttcaact tttttcaatg cacgttctgc attatagccg 2030461 taaagctcat ctgccacgtt gatgacaccg cccgcgttaa tcacgtaatc cggtgcataa 2030521 acgatgccca tttcgtgaat ttgatcacca tggcgtgtct cttttaattg gttgttagcc 2030581 gcacctgcga tcactttcgc cttcagctgt ttaatggtgt cgtcgttaat agtcgcacca 2030641 agggcacacg gcgcataaat atcgcagtct tgtgaataaa tgtcatcagg atctaccgca 2030701 cgggcgccaa aatcttcaac tgcacgctgt acagattgtt tgttgatatc cgtaacgatt 2030761 aagtttgctc cttcttcatg caggtggcgg caaaggttat aggctacgtt cccaacaccc 2030821 tgtacagcaa tggtttttcc ttcaagagag tcggttccga aagcagcttt agctgctgcc 2030881 ttcattcctc tgtacacccc gtacgctgtg actggggacg gatttccaga agagccgaaa 2030941 gcaggagaaa tccctgtgac atagtctgtc tcatcatgaa tgatatccat atcctcgacc 2031001 gttgtgccca catcttcagc cgtgatgtat ctgccattca gtccttgaat atagcggcca 2031061 aacgcgcgga acatttcctc atttttgtct ttgcgcggat cgccgataat gactgttttt 2031121 ccgccgccaa ggtttaagcc tgccgccgcg ttcttatagg tcatgcctct tgccaatctg 2031181 agcgcatctt caattgccgc ttcttcattt tcatatgtcc acattctcgt tccgccaagc 2031241 gccggaccaa gcgttgtatc atgaatggcg ataatcgctt ttaatccaga ttgttcatcc 2031301 tggcagaata ccaattgttc gtaatcgtat ttctccatat atttaaaaag ttccatgttc 2031361 gttcctccta atgtgtgtat tcttcagatg cgcatattgc cagcgcaatg gaatacagtt 2031421 tattttcagc agagtccgct ctgcttgtta aagcaatcgg tgcttttgct cctgtaatga 2031481 cagccgccac gctggccttg gcaaaataaa tcagtgattt atataaaata ttgccggcct 2031541 caattgttgg gacgagaagg atatctgcgt tgcccgctac gtctcccgaa atttttttct 2031601 gggccgcggc aatttgtgaa actgcgttat ccaaagcaag cggtccatca acaatgcagc 2031661 ctttgatctg gccccttttg tacatttgag ctagagcagc tgcattcacg gtcgcttcca 2031721 ttttagggtt caccgtttcg accgctgcaa gggcagctgc ttttggcata ttgttcccca 2031781 ctgcatgggc cacatgaacg gcattttgca aaatctgccg gagctcttcc agcgaaggag 2031841 caatattcat tgccgaatct gtcacaaaca tcagccggtc aaaatccggt atatcgaaga 2031901 cagccacgtg agaaaggaca cttgctgacc gaagcccctc ctgtctgttc aataccgctt 2031961 taagcaaaac agaagtcggc acattgcctt tcattaaaac gtccgctgtt ttatgatgca 2032021 cagcacgaac cgctaatttc gccgattcct caggagtatt ggcatggacg atttccactt 2032081 gatgcccttg catggatgat gtcagctcgt tcagtttttt gctgtcgccc gttaacaaga 2032141 aacgggcgga taggtgctcg gctgccagct ttacagcccg gatcacttcc tcatcctcag 2032201 catgagcaac cgcaatggtc ttatttttgt gtatcgacgc tttgccgatt aaatctttca 2032261 gcttcatctg ttaccacctt tcttgtttcg actccgcctt ttattatgca agttccatgc 2032321 cagctcttaa gggtgctgtc ataccaggta taccgaaaca ttcgtgcaga tgtttgcgtt 2032381 tattctgcaa attattgcat gccttcattt gcaaggccat atttatccat tttgtaatat 2032441 aaattccgaa tgctgacacc gagagctttt gctgtttttg tccggttaaa atgatgcttt 2032501 tcaagcgttt gctggatcaa atgcgcttca aatttttcta ctgcgacaga cagcttttcg 2032561 ccttcaatat ccggaaaatc aaaacctgtt ccctgatctg tgtcattttc tttttgctca 2032621 agttcgaata caggcaagtg atctttttca atccattcca tatgcggatt cagaaaaatc 2032681 atggctcgtc caaggacatt ttcaagctcc cggacattcc caggccaatg gtaggcagat 2032741 aaggcgcgca aggcttgctg tgagagccct tttacattcc tgccgtaatc ccggttgatc 2032801 ttttggataa gtctgacgct caatgcttca atgtcctcca accgctgccg caaaggcggg 2032861 atggagatcg gatagcgatt gatccggtaa tacaggtctt cccggaatgt tccgtccgcc 2032921 atcgcctttt caatatttac atttgtcgcc gcgatcactc tgacgttgac agggatcgct 2032981 ttcgtgccgc ccactctgac gatttccttt tcttgaagga cgcgtagcaa tttggcctgc 2033041 atattttgtg tcagctcacc gatttcatct aagaaaatac tgccgttatt tgcttcctca 2033101 aataaaccct ttttaccgcc gcgcttcgct cctgaaaacg caccatcctc atagccgaac 2033161 aattctgatt cgagcaggtt ttcagaaagg gctgcacaat tcacgcgaat aaatttattg 2033221 tatttccggt cactttcgtt atggatggca tgggcgaaca gttcttttcc tgttcctgat 2033281 tccccgcgca gcaagatggt tgccggtgtt ttcgcaccga gcttcgcctg ctcaagcgca 2033341 accagcattt gctcgctttt gccgataatg tcgtcaaacg tgtatttcgc ttcaagcgtg 2033401 cgaataattt gtctggcgcg attaagctcc gctgtcagca ttttaatttc ggaaacatcg 2033461 tgaatcacgc cgacgctgcc tttcaaaatc ccgtccacaa tcaccggtgc tacattaacg 2033521 atcacttctt tttcattcgg gccgaccttc attctgacac cgcggacagg acgtcttgtt 2033581 tcaagcacct ttaaatgcat gctttcgcct tcggaaatat cagtgtttgc aggcttgccg 2033641 atgacttctt tttcagaaag ccccgtcatt ttcgtatacg ctttattgat tagcaggccg 2033701 atgccgtttt catcaacgac agaaatcgcc tcatcggagg attgaataat tgcctccagc 2033761 atcgtacgga cctgctttaa gttggtcact tcctctgcca gctcgaccgc atcagtgata 2033821 tctttaaaca cacaaagagc cccgagcaga cgtccgcctt catcaataat cggcagtctt 2033881 gtggtcacaa tttgcaaatg atcgcctaac agctgcttct ggttgtattc aggcactctt 2033941 gtttttaaaa tccgcggcat cttagtgctc ggaatcactt cttttattgg gcgcccaatg 2034001 acttcctcac gtttttttcc gaccattttt tcggccatat ggttaaagag aatgatttct 2034061 tcattgatat caataaaaat cattccatca tgggtggaat taaaaattct gtcatattta 2034121 taggtttgct cttttagcat ttgaatcagg tgctgctttt cttccatcag ctgaaaaacg 2034181 atgtatgcca tttttcccgg catgacaatg gtatcttcat gctttctttg aaggagctcg 2034241 tcaaacacgg cttgatcgcc ggtagtatga atgacgatat ccggtttttg ttgtatgtaa 2034301 ggtttccaat cagatgatac ggcaatccca tactgttctg cttctttcaa tcccggcgcc 2034361 tcggggtctt tgtcaactac ggcaatgata tctatgatgg ctgttttaat cagaatatgt 2034421 aataacgccg ttcccctttt gccggcacct actatcagta ccttttgcat cccgataccc 2034481 ctttgtatga aaaaatttgc acacctattt attccgttgc aataatttgc acaaccctat 2034541 gttaccacgt tttcttctct tgacaaaata ttttttccgc tggacaataa aggaaatgaa 2034601 aagataaagg ggttttctga agatgagccg acttcttgcg cttttaatat tagtcatccc 2034661 cggggctatt tctgctttag gcattaaact gatgagagat acacttttcg gccatacaat 2034721 caagccattt tcagctcttt ggctccaagg gttgtcagga ttcatctttt ttgcgatcgg 2034781 cctctatgtg ctggccgggt tcattttata cagagacaga aaacgcaatc aagtcagccc 2034841 gcgattcaga aaacgatagc tgaaaaaaag ccggagaatg ctccggcttt ttttgttgca 2034901 ttattcgtca ggcaaaacgg tcttggcaat cgttttgtct aacgcttcat agtcataata 2034961 agaaatcgta tcgtacagtt cttttcgtgt ctgcatatca tgaagtcctt ctttttgtga 2035021 gccgtgctcc ttcatcaaac caaacatccg ctcacaagct tttgccgccg ctcgaagcga 2035081 ggtgacagga tatatcacca tgtgaaaccc catatcttcg aattcatcgg cacgataata 2035141 tggcgttttc ccaaattcag tcatattcgc aaggagcgga acggggatac gctcagcaaa 2035201 ctggcggaat tcattctccg cctgtagcgc ttccgggaaa attgcgtccg ctcccgcctc 2035261 aatgtaagcc tctgaacgtt ttattgcggc atcaagccct tcctgcgccc tggcatcagt 2035321 acgggcaaca acaataaggg agggtgccgc ttgtttaatg gcttttattt tttgcgccat 2035381 ttcctttatc ggaactagct gtttgccatt taaatgtccg catttttttg ggagctgctg 2035441 gtcttccatt tgaacggctg ctaccctggc ttcaagcatc tcccgggctg ttcgggcggc 2035501 atttaagaca ccgccaaatc ccgtatcgat atccacaagc aaaggcagat cagctgcacg 2035561 cacaagatct ttggcccgtt cagctatctc tgccgatgtg atgatcccta aatcaggcag 2035621 ccccctgctg gctgtatagg cagcaccgga caaataaata gcagaaaaac cggcttcttt 2035681 cgcaagcaaa gcggccatcc cgtcatgggc gccgggaatt tgaagaatgt ccggtgctga 2035741 catcagcttg cggaaacgcc cggcaagctc ctcttgtgac gattgcttat tgacgatcca 2035801 cgacatgaaa caaaatcccc cttttacatg cagaacatgt ctacgaattc atttacgcgc 2035861 atcgtttgta atgtctcata gctggtacag cgctcataaa tgtgtttgtg ctgtttatca 2035921 ggaaaatggg ttttgagatt gtcagaaaac ttttccagca gtttcggcac tgcttcctct 2035981 cttcgaaaac gatggccgag gggaaactca cattccacca tttccgtgct cgttccatct 2036041 ttaaaatgaa cctgaacggc atttgagatg gagcgtttat caggcttcaa ataatcctcg 2036101 gtatatgttt tattttcagt cacttccatt ttatcacgaa gtttatctat tctcggatca 2036161 ttcgctgttt cagcttcata atgctgtgcg gtgatatcac caaaaagcaa accgattgct 2036221 gtaatgtatt ggaggcagtg atcacggtct gccggattgt ggagcgggcc ttttttatca 2036281 atgattcgga tagctgattc atgcgttctg atgacaactc ggtcaatctc gtcaatccgg 2036341 ttctttacct gcgggtgaag aatgacggcg gactccgccg ctgtctgggc gtgaaattcc 2036401 gcaggataag acactttaaa taacacattt tccatgacat aagcgtcgag cggacgggca 2036461 agcttgatct ctttcttatt gaataaaacg tcttggaacc cccaacccgg tgcactcaag 2036521 gctgtcggat aacccatttc cccttttaac gacatcagcg ccaaatgaac acctctgctc 2036581 gttgcatctc ctgccgccca tgatttacgc gagcctgtat tcggtgaatg gcggtatgtc 2036641 ctcaatgctg cattgtcaat ccatgcattc gaaagcgcat ttttgatttc ttctcttccg 2036701 ccgcccaaaa gctttgctgc aacagcagtt gtcgcaactt tgacaaacag cacatggtca 2036761 aggccaactc gatttaagct gttttctaac gccagcacac cttggatctc gtgtgctttg 2036821 atcatcatct caagtacgtc gcgtaccgtt aacggctctt ttccttcaga cagcctcact 2036881 cttgatacat aatcagcagc ggcaaggatt cctcccaagt tatcggatgg atgcccccac 2036941 tccgccgcca gccacgtatc gttgtaatcg agccagcgaa tcatgcagcc aatattaaac 2037001 gctgccctca caggatcgag aacatatgac gttcccggca ctttgcttcc attcggcaca 2037061 gtcgttcctg gaacaatcgg gccaagcagc tttgtgcatt ccggataccg tagcgccaag 2037121 attccgcagc ccagggtatc cagcaataca tgccccgctg ttgtatacgc ttcggcacta 2037181 gtaatctctt tctcaagcac atagtctgtg atttcttcga taacacgatc cgttttcggc 2037241 attctaccag ctcctttcat gattttgttt gatatcgcgg gcccatgtaa ctgacacggg 2037301 gacggaagag ccgattattg gcatgctgtt cgatcacatg ggcgcataaa ccggacgttc 2037361 tcgcgctgaa aaagatcggc gtatataaag gaatcggtat gccgagcatc caatacactg 2037421 gggcagcata gtaatccaaa ttcgggtaaa gccctttttc cttctccatc agccgctcac 2037481 ccgcttcgca catctcatat aaacgatggt caccggcttt atcgcataat tgctgcagcg 2037541 cctctttcat catgagtgct ctcgggtcca tttttttcat atacacccgg tggccgaagc 2037601 ccatgatttt ttcttttctt ttcagttttg tttgcaaaag ctgctcaaaa tcagatgtcg 2037661 tttttgcctc caaaagcaaa tacatcacag cttcgtttgc tcctccgtga agattccctt 2037721 tcagggaagc gacagcccca gtcaaagccc cataaagatc tgaatgtgta gatgcaatga 2037781 ccctggccgc aaaggttgaa ttcggcatct catgctcact gtacaggacg agcgaccggt 2037841 caaaaatctg ttcttccaat gaagacggca atttccctgt catcatgtag agaaaattcg 2037901 cactgtagga tagggtttga agcggaagaa tcggttcttt cttattaatg atcctgtagc 2037961 tggcagcagt gagggcaggc attttcccaa gaagctgata ggcgcgttct ttgtttgcgg 2038021 aaggagaccg atcatcaatt tgccgatcat agccagcaag tgccgacagg ccggtacgca 2038081 gaccatccat tggatgagtg tcctcaggga gcagctcaag cagacggaga tgatcagcag 2038141 gcaggcttga ggcactgttt attttacgtt ccagcgtttc catttcactt tcttctggca 2038201 gcctgccctc cagcaataaa tggacaagct ccagatagct ttttgtttca gaaagttcta 2038261 ttaaatcata gcctcttatc aaaatctggc tggactgcgt gtcaagataa gaaatatgag 2038321 tttctgccgc aatcacaccg tccaaccctg gagaataatg ctgtttctcc tccatatcct 2038381 caacctccgt ttttgcgttt tttgtctatc aggttccgcc aagcaaatac ttggaaataa 2038441 tcagtctttg aatctcgttc gtcccttcat aaatttgcgt cacctttgca tcgcgaagca 2038501 ggcgctcaac tggataatcc ttcatatagc catatccccc ataaatttga acggcgtcta 2038561 acgccgcctt tacggctgca tcggaagcaa attgtttagc catagacgct tcttttccac 2038621 agtttaggcc gcggttatga aggtctgcag cgtggtagac aagatgtctt gccgcctcag 2038681 ctctagtcgc catatcagcc agcttaaatg atatgccttg attggctgca atcggccttc 2038741 caaattgcac tcgctgcttc gcataatcaa cggcatgctc aagagccgcc tctgcaattc 2038801 cgagggcctg tgccgcaatg ccgatccggc cgacatttaa attcgccatg gcaatgtgaa 2038861 agccatcccc ctctttgcca agcaaattgg cttcaggcac ttctgcatta tcaaaaatca 2038921 gttccgtagt attggagcca taaagcccca gctttctttc tttttttcca acggtaaaac 2038981 cgggtgtgtt tttttcaaca ataaaagccg aaatcccgtg cctgccttga tctggagctg 2039041 ttaaagcaaa tgtgatatag atatcagctg ctccgccatt cgttatgaat attttcgatc 2039101 cgtttaatag gtatttgccg ttctttttga ttgctgttgt gcggaggctc ccggcatccg 2039161 accccgagtg aggctccgtt agtgcaaatg cgcccaaatg gtctcctgac gcgagatttg 2039221 gtatatattt catcttctgt tcttcgttgc cgaaatacag aatcggattc gtgccgactg 2039281 aggtatgaac ggagagaatc acgccgacag ccgcgctgat tctagaaatc tcatgaattg 2039341 ccaaaatata agaaacaacg tccgctccag caccgccgta ttgttccggc accggtattc 2039401 ccatcagtcc gtgtttaccc atttttttga tcagctgaaa gggaaattcg tccgttttct 2039461 ccatgatttc cgcagcggga gcaatttctt ttcgtgcaaa atcacgcacc atttttcgca 2039521 tcatgacttg ctcttgggtt acatgcaact cggccacccc cggatggaat agacttcagg 2039581 aagtcttctc ctcatagtca taaaaaccgc gtccgctctt tttgccaagc cagcctgctt 2039641 tgacatactt gcggagcagc gggcaaggac ggtatttgga atcgccaagg cctgagtgaa 2039701 ggacttccat aattgataaa cacgtatcca gtccgataaa atccgctaat gcaagcggac 2039761 ccatcggatg attcatgccc agcttcatca cttcatctat tgcctccggc ttcgccactc 2039821 cctcatacac gcaatagatg gcttcattaa tcattggaag aagcacacgg ttggaaacaa 2039881 acccaggaaa atcattgact tctaccgctg ttttccccat cttttccgct aatgccataa 2039941 catctaaggc cgtttcttct gatgtagcca agcctcgaat cacttctacc agcttcatta 2040001 cagggacggg attcataaaa tgcatgccaa taacccgttg aggccggttt gttacagcag 2040061 cgatttctgt aataggcaag gaagatgtat tgctggccaa aatcgtatga ggcgggcaaa 2040121 tgcgatcaag tgttttaaac atctcagttt ttgccgccat gttttctgcg atagcctcaa 2040181 tcacaatgtc cgcatgctct gcctcctcaa gtgtttgaga aatcgaaatg cggttgatta 2040241 cgctcttcac ttccgtctcg gtcctttttc ctttctcagc atcacgggcc agctgtttct 2040301 tcagccgttt caatcctgcc tccgcggcct ctggattcac atcatacatc cgcacataaa 2040361 agcccgcgtc ggcggctgtt tgagcaattc cgctccccat ctgacctgcg ccagctacca 2040421 tgatttgttt gatttccatt caaatcccct ttttcatcat gttttaatga acctgcacta 2040481 agacggcgtc tccctgtgct gccccgctgc aaatagcggc aacgcccaga ccccctcccc 2040541 gtcgctttaa ttcataaaca agcgtcatga gaattctcgc accgctcgcg ccgatcgggt 2040601 ggccgagcgc gatcgcaccg ccattcacat ttactttttc aagatcgaaa cctacgattt 2040661 tttcacatgt caaaacaact gaagcaaaag cttcatttac ttcaaacaag tcaatatctt 2040721 ggacagttaa accattcttt ttcaggagct tgttaatagc aaaccctggc gctgccgcca 2040781 gctcgtgcgc tggcattccc gtagttgaaa aaccaagaat tgtagccaga ggccgtttgc 2040841 caagctcagc agctttttcc tcagacatca gcacgaacgc gccggctccg tcattgactc 2040901 caggagcatt gccggctgtg atagaaccgt cacttgcata aatcggagca agttttgcga 2040961 gctgatccag acttgtgtca cggcgaatcg cttcatcttt atcaacaacg tttggttttc 2041021 cttttcgacc gatccagttg acgggaacaa tttcatcctg aaacttccct tcatcggcgg 2041081 ccttagctgc ccttgcatga cttctcaacg cccattcgtc ctgctctctt cgtgagattg 2041141 catattcctt ggcagctgta tttccgtgaa cagccatgtg cacctcgtca aatgcgcacg 2041201 ttaatccgtc atacaccatt aagtccctaa gctcgccgtc ccccatccgt gctccccagc 2041261 gcccggcggg aacggcatac ggaatattgc tcatgctttc catccccccc gcaacaagta 2041321 tgtccgcatc ctgcgcccga atcatttgat cacataaagt gacagcgcga aggccggaag 2041381 cacagacttt attcagtgtt tctgacggca cactccaagg cattcccgcc agacgggcag 2041441 cttgacggga aggtatctgc cctgagccgg cctggacaac catgcccatg acgtttcctt 2041501 ctacatcatc tccagagact ccagcctgtt gcagcgcctc cttcatcaca atgcccccaa 2041561 gctcagcagc tttcacctct ttcaaaactc cgccgaattt gccaaatgga gttcttgcag 2041621 cacttacaat gactgttttc ctcatggttt cacctcattc agaagataga cagcgcttac 2041681 aatttctagt tgtcttctat gaatgtatgc tttgaaacgg gcatgaatga atgaaaaaag 2041741 aaggctgcgt caaacagcct ccttctaaca actattcatt tttcagcaat gccgaagcct 2041801 tttctggaaa gtcggtaaac atgccgtctg ctcccgcttc aatgagacgc ttcatatctt 2041861 ccggacgatt gactgtatac ggccttacct taatcaaacc gttcctcatt ttcttcagta 2041921 cttcatctgt gacccctggg ctgtttatct tcgggtgata gccggaagcc ggaatagacg 2041981 cgatatatcg atctgcctga taaagcacat ctgaagttaa tactgcccgt tcgatatgcg 2042041 gtgcaagccg ggcgcacagc gccaagctgt catgattaaa cgtggatagg atgactctgt 2042101 cctctacatt aaatcgcttc actgcctcca gcactttttc ttccattccc tcatagcgga 2042161 tcacgctgtt ttttaattca atgttgatga gaaaatcctt ttttaccgcc cacgagagca 2042221 catcttctag cagcggcact tttatatcgc tgtacgcttg atcgtgacca gcggccgcat 2042281 tcgcagtctt tacctcatca taggctgtat ccttcacgaa tcctttaagt gatgtcgtgc 2042341 gattaagtct ttcatcatga attacaacaa tgcgtccgtc tttcgtcagc tgtacatcaa 2042401 gctctatccc atccgctccg gcttcaattc ctttttcaaa tgcaagcatt gtattttcgg 2042461 gaaattgacc tgatgccccc cggtgggcaa aaatctttgt catcgtttca cctcaaaccc 2042521 taaagttttc tccattatac ttattttgtc ggctccactc taggattaag gctgtatcaa 2042581 tctactgatc ataataagaa tcaatgccat tgacaatcgc atctgcggcc ttttgctggt 2042641 attcttcact tcccagcttg tccgcgtcag agctgttcgt gataaaccca agctccgcca 2042701 acacacttgg catttgtgaa tatgtaatga cgtaaaagtc tgattctttc acgcccctgt 2042761 ctctcgtttg taaggaagaa acgagctgtg actgaatatc ggatgccaga cgccggctgt 2042821 tctccccttc ataatcagat tgaaaatacg tttctgttcc tgaagctgaa gcaacccctg 2042881 aattcacatg aatgctgaca aaaaggtcag cctgattggc acttgcctta gccactcttt 2042941 cctccaaggt cagaaaatga tcgtcagacc gggatgcaac aggattggct ccctcctctt 2043001 ttagtttgtc tgtcacatgc tctgagacag ccaaattaat atccttttca aagagcccgt 2043061 ttccgaccgc tccactgtct tcaccgccgt gtccggcatc aatatacact gttttccctt 2043121 ctatcggctc tgctgcctgt gcacaaggcg cgagcgtcaa agccaatccg cacagcgcca 2043181 agctcctcca taacattctc aacttactcc ctccggtcac gagttctttc gcagctgaat 2043241 atcttccagc tgtaaagttc cattatcctt ctttgtatat ttcaccagga catgtgtctg 2043301 atctggcagt gattcacatt catcacgttt atccttcgga acttgtatca tggtttcttc 2043361 tccattaaga gaaaccgcaa tcgtatgagg atcagccgag ccaatgtatt ttccctcttc 2043421 ggtaaacctc ggcactgagt catccgcact tgcaacactg caccccgaaa gaaagagcgc 2043481 agtaaacagc aaaagaaccg tttgtttcac atgaccacct cttcctgatg tttggctttt 2043541 atctttgacc agaatggaga atttgtaaag acaacgcgaa tgcaggcgag caagttccat 2043601 gattttcaaa agggctatac gacccgatca tttcctgttg ttagaaagat aacgagcaga 2043661 tttgtctatg aggatggctc taattgaggc gccaattaga aaaaattagc ggaaagaagc 2043721 aactttttat tcattttaaa aaatttgaga atagggtgag caaatcgttt gacgggtggg 2043781 tcagccaagc gtaacctttt aaaggatatt tactttattg aaagaagtta aagccatgaa 2043841 aaaattcgtt ctgctgctgg cggcagctgt catcacatgc tccatcggcc accaaatcag 2043901 tggcggctac aaaggccccg aaaaagagcg gccaaaacat cactctgcac tcaagatatt 2043961 cagtcggtaa agcagatcaa ttgcattaat ttttacatat aggctagaat atgtgcgaat 2044021 ccaaacgaaa gaagatgatc aaatgaatcc taagtataag ccactttttg aaccatttac 2044081 gtttaaaagc ggcgttacaa tcaacaaccg gatcgcagta gcaccgatga ctcattacgc 2044141 ttctaatgaa gacggtacaa tatctgaagc ggagctcgac tacatcatcc cccgttcaaa 2044201 agagatggga atggtgatta cagcctgcgc aaatgttaca ccggacggaa aagcattccc 2044261 cgggcagccg gccatccatg acgattccaa cattccaggt ttaaaaaagt tagcacaagc 2044321 cattcaggca caaggcgcta aagctgttgt acaaattcat cacggcggta ttgagtgccc 2044381 gtctgagctc gttcctcaac aggatgttgt ggggccaagt gacgtgtttg ataacggcaa 2044441 acaaattgct cgcgcattaa cagaagaaga agtggaaaac attgtgaagg cgtttggaga 2044501 agcgacaaga cgcgccattg aagccggctt tgacggtgtc gaaattcacg gtgcaaacgg 2044561 ctacttaatt cagcagtttt attctccgaa aaccaaccag cgcacggatc gctggggagg 2044621 aagcgatgaa aaacgattag ccttcccgct cgctattgtc gatgaagtga aaaaagccgc 2044681 ttcagaacat gcgaagggtg cattcttagt cggctaccgc ctgtctccgg aagaacctga 2044741 gacaccggga ttgacaatga ctgaaactta tacgcttgtt gatgctttag gggataaaga 2044801 attggattat cttcatatct cactgatgga cgtgaactca aaagcgcgcc gcggtgcaga 2044861 tccgactcgc acacgcatgg acttattgaa tgaacgtgtc ggaaacaaag tgccgctgat 2044921 cgccgtcggt tccatccatt ccgctgatga cgcgcttgcc gtcatcgaaa acggtattcc 2044981 actggtcgct atgggacgcg aaattctagt tgaccctaac tggacggtaa aagtaaaaga 2045041 aggccgtgaa aagcaaatcg aaacagtgat caaaggcaca gataaagaaa aatatcattt 2045101 gcctgaaccg ctatggcaag caattgtgaa cacacaaggc tgggtgcctt ataaagatta 2045161 atgtgcaaag actgccgaaa cgattcggca gtcttttttc cctttatata aatagtttgt 2045221 gtacacatct aaacagcaaa agaaagagct ccccaccaac ttcgaaaaga aaatccagga 2045281 aaaacccctc acgctttctt gcttttttct ttttcattcg tacgtctcct ttttacatga 2045341 atacgcctta cttacgattt tgcaggagaa aggtttcatt ttataacgga cacatctagg 2045401 gtcgatcatg cttcgtgatc ctataagatg tatgaatgga ccaagagtgc aggtaatacc 2045461 gccatttgct ttccttactt ttcaaaccta tcctttacta tatgcggata cttaatattc 2045521 ttctcccata ctacaaatgt ccccaaaaca aaacgcctcc tatttatcag cgcaaactaa 2045581 taaataaaag acgtttgatt taatgaccac ttaataagct catgtttaag aagccttatg 2045641 ctctaacctc agcttatccg caaccattgc aatgaattca ctgttggtag gtttagcttt 2045701 tgtcatgctg acagtataac caaacaacga ggaaatggaa tcaatgtttc ctctgctcca 2045761 tgccacttca attgcatggc ggatcgctct ttctacacgg cttgcggttg tgttaaattt 2045821 tttggcgatg tccggataga ggacttttgt aatgctgccg agcaattcga tgtcattgta 2045881 taccattgag attgcttcgc gcagatagag atagccttta atatgggctg ggacgccgat 2045941 ttcatggata atgcttgtga tgctcgcgtc gagatttttc ttctttggtt caggctggct 2046001 gctgcgtata atactgcttt gcgatgatgg cgcacgatgc gtcacactgc tggcatttcc 2046061 gctgacctgg cggatatggc cgacaaggtt ttccatatca aacggtttga gaataaagta 2046121 ggacgcgcct aaatcgacgg cctttttcgt gacatcttcc tgcccaaagg ctgtcagcat 2046181 aatgacattc ggctgttttt tcagatctga ttccctcagc ctctctaaaa ccgcaagtcc 2046241 gtctagatgc ggcataataa tatctaatac gagcacatcg ggatcttttt ctttaaacag 2046301 cgacaggcat tcctgtccgt tataagcaac gccgatcact tccatgtctt cctgtccttc 2046361 tatatattca cttaacaggc ttaccagctc tcgattatca tcagcaacac aaactttaat 2046421 tttctccacg tttcttcctc cccaaatgta gttaacagga ttcacccttg ctacatgttt 2046481 acattcgaca aaaccgctat ataccctcta aaaaaatcat aatcaccaat attagtggca 2046541 tatctttgtt attctatgtt tttctctgtt tttcgactaa aaatgaaatt tgacaaacaa 2046601 ggaaacgtga atttgtcgaa aaatcttctt ttgtatattt taccgtatgt attctgagaa 2046661 gtgaagaggg atcaggatat actgatgaac gaatggatgt gcacgaaaaa aataagctgc 2046721 gcttctcgcg cagcttaccc agttgttttg acttgatccg cttgttttaa aagttctttc 2046781 gcatggcgtt tcgttaagtc ggttacttcg acacctgcaa tcatgcgccc gatttccgct 2046841 accttttcct gcttagagag cggcttgaca cgtgtcgtcg ttctgccgtc ttttaactcc 2046901 ttcgcaatat aaagatgcgt atcggccatg gcagccacct gaggcaggtg tgtaatgcac 2046961 agcacttgtg atcctattga caccttatgg atcttctcag caattgcctg tgcgaccctg 2047021 ccgcttacac cggtatcaac ctcgtcaaaa atgatcgatg tcacatcctg ttgtgaggaa 2047081 aaaatgcttt ttatggcaag catcacccgt gacagctctc cacctgaagc gactttcgaa 2047141 agggatttca gcggctcgcc tgtattggtt gaaattaaaa acttcaccag gtcaatccct 2047201 tgttcagtca gctgaacggg ctggccgttt acaagcggcg cctcttcatt gcgtgacgct 2047261 gttctgacct taaattccgt atcaaaagtt gatttttcca tgtacaggct ttttaattcc 2047321 cgatgaatct catcagccag ctttttcgcc catgtttttc ggatttgtga cacatttgcc 2047381 gcttccactg cgacatcttt gccgacggag tcaagctcct ttttcaagct ttgaaggtgg 2047441 ctgtccctgt tttcaatttg gtcaatctct tcttcaattt tagaagcata ttccaaaatg 2047501 tcttcaacag tggcaccgta ttttcgtttc agctgtttga tttcattaag tcgcgtctca 2047561 atatagttca ggcgttccgg atcaaattca agctcatcca gcatatttct catctgaaat 2047621 gtggcatcct caagcaaata gtaggagttc gaaacacttt cagacatttt tttcagcggt 2047681 tcgtttatat cagatatatc ttcaagctgc gctgatgcca ttccaaccca gtccaatccg 2047741 ccctgctcac tgcgaagcgc gttatatgca ttttgcagcg actcatatat cttctcaaag 2047801 tttgaaattt gctggcgctc ttcttggagc tgttcatctt cgttaagctc aagctttgcc 2047861 gattcgattt cttcgagctg aaattgaata agatcaagac gatgggccat ttcctgttcg 2047921 ctttcagaaa gctgcttaag ctttttgagc agcttcacat accgctggta cccttcctga 2047981 tacgttttga gcgcgctttc cacttcggcc ccggcaaact tgtccaaaag ctggagatga 2048041 ttttcgtctt ccattaacag ctggttatcg tgctgcccgt gaatatctaa taaaagcctg 2048101 ccgatctctc ttagtgaagc aatcgtgaca agcttgccat tgacacggca aacgcttttc 2048161 ccgctcgtgc tgatatccct tctcatgacg atcatttcgt ctgaaacgtc gattccctgc 2048221 tcagcgcata cgcctaaaac aggatggccg ctctccaaca gaaacagccc ttcaagttcg 2048281 gcttttgctt ccccatatct aacaaattca gatgatccgc ggcctccgac taaaagagaa 2048341 atggcatcta tgatgatgga tttgccggct ccggtttctc ctgttaaaac cgtaagcccg 2048401 cgttcaaaag aaaccgtcag ttcctcaata atggcaaagt ttttaatcga tagttcagct 2048461 aacaaacagc attacacctc ttatctttgt tagattttct gttacagcag ttcaaggagc 2048521 ctgtttttta cgccttctgt atcttcagga gtccggcaaa taattaaaat cgtatcatct 2048581 ccgcaaatgg tccccatcat ttcatcccag tccaaattgt ccatcagcgc cccgattgcc 2048641 tgggcattgc ccggcatcgt tttcagcaca atcatatggc ttgctgagtc tattttcaca 2048701 aatgcgtcca tcaatgcccg ctttagcttt gacagcggat tgaaacgctg gtccgccgga 2048761 agactgtatt tgtaagaacc attatttgta ggcactttta caaggtgaag ttctttaata 2048821 tcccgtgata ccgtggcctg cgttactttg tatccatcct gctttagcat gtcgaccaat 2048881 tcatcctgcg tttcgatttc attgcttgta atgatctctc tgattttaat atgcctctgg 2048941 cctttgttca tgtaagcacc tctatttcca agcttatctg ttcttttatg ttatatgatt 2049001 ctctgcacat tgtacatgaa tgcagaaaaa aggaataata gcgccctatt attccggtac 2049061 atctgctttt ttttctttta acgtcttatg tgcttcttct acaacgcgca tgatctcttc 2049121 ttccggcagt tcctggcctt cctgtccctc tcccggccaa tgcaaatgaa ggagaaactc 2049181 aatatttccg tctcctcccg tgattggaga aaatgacaag cctttacaga tatagccttc 2049241 agcggcagaa aaactgatca ttcgcttgag cacatcagca tgcactttag gatctctaac 2049301 aatccctttt ttgccgacgg attcccgtcc cgcttcaaac tgaggcttaa ctaaagccat 2049361 gcagtcgctg cccggtacga gcaaagtcct taggacaggc aggatgagcc gcagtgaaat 2049421 aaaggacaca tcaattgtgg caaactccgg catgcccttt gtaaagtctg ccggtgttgc 2049481 ataacgaaag ttcgtccgtt ccatcacgac gacccgttca tcctgtctaa gcttccatgc 2049541 aagctgatta tagcctacat ccacagcgta tgactgttta gctccatttt gcaaagcgca 2049601 gtccgtaaaa ccgccggtgg aggagccaat atcaatcata attttatctt tgacagagac 2049661 gggaaattcc ttcaacgctt tttcgagctt taagccgccc ctgctcacat acctcagcgg 2049721 gtttcctttg acagttaacg gaaggtcgcg gtcaattttt tctccaggct tgtccaagcg 2049781 gttttcgttt gaatagacga tccccgccat aatggctctt ttggcttttt cacgcgtttc 2049841 cgccagccct ctttccacta ataatacatc taatcgttct ttctttgacg tcatgatcca 2049901 attcctttgt gtgtctttgg tggcatcagt aatctaatac gatttgccac ctgctgtttt 2049961 gtcagtccaa tttcctcaag aagcgctgtt acacttccgt gttcaataaa ccgatcaggt 2050021 atacccattc tgtcaatcgg agtatgatat tcaccttgat catgagcgaa ttctaaaatc 2050081 gagcttccga aaccgccttc taagaccgct tcttcaattg ttaaaattgg caagccttct 2050141 tttaggatac tcttcatcat cttttcatca atcggcttaa taaaacgcgc attcacaacg 2050201 cgcacggaaa ggccttcttt ctgcagctct tcggctgctt caatcgccat ttcgattgtt 2050261 gtgccgaatg ttaagatgac agcatcgttc cctggacgca gcacctccca cgtaccgatc 2050321 ggaatcgttt tcaactgttc atccattttt acgccgagtc cgtttccgcg cggaaaacgc 2050381 attgctatcg ggccttcgtc atagctaagt gctgtatgaa ccatgtgctg gccttcattt 2050441 tcgtctttcg gcatcattaa gaccatgttt ggaatgtggc gcataaacgc aatatcaaac 2050501 acgccttgat gtgtctctcc atcagcgcca acgagtccag cacggtcaat tccaataaac 2050561 acattagcgt tttggcggca gatgtcatga acaacttggt catatgccct ttgcaggaag 2050621 gttgagtaaa tcgccaaaaa cggcttcata ccctgcattg ccatagctgc agccattgtt 2050681 gcggcatgct gttctgcgat tcctacgtcg aacatccggt cagggaattc ctttgcgaag 2050741 ccttcaagct ttgaaccgac aggcatagcc ggcgtaatgg ctacaatgcg tccgtcctcg 2050801 cgcgccattc gctgcacagt tccgctgaca agaccgctcc acgaaggagc tgcggctttc 2050861 ggctttacaa agtcaccggt attaatttta tatggtccgg taccatgcca tgtcccaatc 2050921 gtatcggtct cagccggttt gtaccccttc ccttttttcg taatgacgtg cagaagaaca 2050981 gggcctttcg tttttttggc gtattgaaga ttctcaatca gctcatgata agaatgtccg 2051041 tccactgggc ccaaatacgt aaaaccgagc tcctcgaaaa acattccgga gacgagcatg 2051101 tatttcaggc tgtctttgac ccgttccgcc gtggcggcaa gcttgccccc aactgccgga 2051161 atctttttaa ataagtattc aagctcatct ttgacccact ggtatttccc cgcagtgcgg 2051221 agccgtccga gcatagagtg aatggcaccg acgtttggcg caatactcat ttcattatca 2051281 ttaaggatga caatcatgtc ttttttctcg tcgccgatgt ggttaagggc ttcgagcgcc 2051341 ataccgccgg tcagcgcgcc gtcaccaatg atcggaataa tatattcatc cgttccttta 2051401 atatcacggg cagctgccat tcccatcgcg cctgacagag aagtcgagct gtgcccggtt 2051461 tcccaaacat cgtgctcgct ttcactccgc tttggaaatc cgcaaagccc tttgtactgg 2051521 cgaagcgtcg caaattcttt tccgcgtcct gtcagcagct tatggacata cgactgatgg 2051581 cctacatccc ataaaaattt gtctttcggg ctgttaaatt ccttatgcag ggcaacagta 2051641 agctctacga cacctaagtt tgggccgatg tggccgccgg aagcggataa acttgtaatt 2051701 aaaaactgac ggatttcatc acttaatttc tctaattcat caatggacat gttttttaaa 2051761 aacgacgggt cctgtattga taaaagatcc aaagcggatc aactcacttt cagcatgaat 2051821 ttctgcaatg atacatgtct tttgcatgcc gagctgacaa taatctcaga cataaaaaaa 2051881 gacaaacgcg cttttccttt tcatttttca tataaactgc ttacatttta ccatacctcg 2051941 tgcagccgct tcaaattagg atcgttttag tgatctcttg ccgcaattaa atcacaaagc 2052001 tcatataaaa ggtctttttg aagagagagt ccgccgatca atcgcttcgc ctcttttata 2052061 tgaacatcca atttatgttt ggccccttcc aatgaaagaa gcgacgggta tgtcgatttg 2052121 tcatttgtgg tatccgagcc gacacgtttg ccgattttct cttcactgcc ttctaaatct 2052181 aaaatatcgt ctctgatttg aaatccgatt ccaatgtggc tgctgaaggt acgcagtgtt 2052241 tcaatgtctt cctcaggcgc atcagccaaa atagcaccgg cgattacaca aaagccaagg 2052301 agcttggcag ttttccgttc atgaatggat tcgagctctt caagcgtgac ttgtcggttt 2052361 tccgcttcca tatcagctac ttgcccaccg accatgcctt cggtgcctgc cgctgaaatc 2052421 agttcattca caagccgcag gcgcttttct gctgacacct cgtctgacac gtgggaggta 2052481 atcagcttaa agctttctgt gagcagcccg tcacccgcta atactgccgt cgcttcacca 2052541 aacactttat ggtttgtcgg cttcccgcgg cgcaaatcgt catcatccat gcatggaaga 2052601 tcatcatgaa ttaacgaata cgtgtgaatc atttcgacag cacagcccac cggaatgccg 2052661 tctttttcgc tttttccata tgcatttaaa acagccagta caatcagagg ccgcaaccgc 2052721 tttccgccgg cctgtagaga atatagcata gatttcttta atgagtccgg catatcaagc 2052781 ttttctgtat agacagaaag ctgattttca attgtttttt tccggtccgc cagaaagctc 2052841 gttaatttat ttgtcacctt cgtcttcctc ctgaacactg aaaggtgcca gttcgccgtc 2052901 ttcttttaaa atgaagtcca tttgcttttc gactttttgc agcttttcat ggcacatttt 2052961 tgacagagcc atgccttctt ggaaatagtt aatggcttgc tctagaggca catctccctc 2053021 ttcaagcttt gatacaatgc tctcaagccc tttcatcgct tcttcaaatg tcatgttttc 2053081 attttttttc acgtctgtca tttttcttcc cctctctttt ctaatacttc acaggtcagc 2053141 acgccatcct tcagcttgat ttcaagccgg tcctgctctt ctatttgact gacactttta 2053201 atgagtttat cttctttata agccaagctg tatcctcttt ccatcacttg aagaggactt 2053261 agtgcattca gcttgccaag aacggtttga aattgggaat gcagctgctt catttggata 2053321 ttcatatttt ttctcagctg atttgtttgt tcctggtatc gtgttctcgc ttgtttcagc 2053381 tgttcatgag gatgcaatgc ctctaatctg tacgtttcac gctccagctg tctgcttttc 2053441 cgatctaaaa gagcggtcag ctgtgcttga aactgctggt acgcgaggtc aaactgctgc 2053501 tctttttgcg catacaaacg ctttggaaaa cgaaaggcat aggacgattg cagcgtttgt 2053561 atccgttctt ttttctggcc gagatgctgc tgcattgctc ttgtcattct gacttccgct 2053621 gtttttgtcc gttcgattaa atcagtggta tgaggcacag caatctcagc tgctcctgtc 2053681 ggcgtcgcag ctctgatatc ggcgacaaaa tcactaatcg taaaatccgt ctcatgtccg 2053741 actgccgata taatcggaat attggaagca aagatggcgc gtgctacaat ttcttcattg 2053801 aatgcccaca gttcttctat cgaaccgccg cctctcccga caattaatac gtcgcaaatc 2053861 tctttttcat ttgcctcttc aatgcgcgta acgatggatc tgctcgcatt ttcaccttgt 2053921 acgagcgctg gaagaacaat gacttttaca aggggatatc ttctttttag agttgtaata 2053981 acgtctctga cagcggcacc cgttggagat gtcacaaccc cgattgtggc tggaaatgcg 2054041 gggatttgtt ttttgtagcg gtcgtcaaat aaaccttctc cggcaagctt cttttttaat 2054101 tcttcgtacg ctaaataaag cgctccaacc ccgtcaggct gcatttcttt ggcatataat 2054161 tgatagtttc cgctcggttc atatacggaa attccgcctc tgaccagcac tttcattccg 2054221 ttttcaggtt taaaaggcag acgctcgctt tgtctcgcga acatcaccga ctgcattctt 2054281 gcgttttcgt cttttaaagt gaaataaata tgccctcgtg tgtgtatctt tacattcgac 2054341 aattcgcctt taatccaaat attttcaagg tgaggatcta catcgaattt tcgttttata 2054401 tactttgtca gcgctgagac ggtcacatac gctgcttcac ccatgtctaa aaactcctct 2054461 cctaagcatt cctgcaccat aactaaagaa aacccgccct ggctttagga gcctgaagaa 2054521 gcgggtatcg tgctcatatt caaggcgggt aaacatttcg cctgtgaata tctccaatta 2054581 tctatgataa cgtacgtttc gcagatttaa cagtattatg cgcaagcatc gtgatggtca 2054641 tcggacctac tccgcccgga accggcgtta tgaaggacgc tttttccttt gccccttcaa 2054701 attcaacgtc tccgcaaagc tttccgtttt ccagacggtt aacgccgacg tcaatgacaa 2054761 cagcgccctc tttgatctgg tctgcactga tgaagttggc tctgccgact gccaccacca 2054821 ggatgtccgc ttttttcgta tgttcagtaa tattttctgt tcttgaatga cagtaagtaa 2054881 ccgtcgcgtt ttcatttaat aaaagctggc cgacaggttt gccgacaatg ttgcttcggc 2054941 cgactacaac aacctcttta ccggaaaggt caatattggt tttcttcaaa agctcaacaa 2055001 ttccatgagg cgtgcaagga agaaacgtat cttcgccaag cagcattttc cctacgttta 2055061 acggatgaaa accgtctaca tctttatcag gggagatacg ttcgatcacc gctttttcag 2055121 aaatatggtc tgggagcgga agctgaacga gaatgccatg aaactcaggg tcttggttat 2055181 attgatcaat aatggaaagc agttcagctt ctgtgaggct gctgtcaaat tgatcgagct 2055241 tgaaattcat tcccattgtt tctgccgctt ttttctttcc tcgcacgtaa gagtgagaag 2055301 caggatcatc tccaatcaaa ataaccgcca gtccgggagt gacgccttgc tttttaagct 2055361 cttctacctc ttttgccaat tgttcgcgtt tttctctagc cgtttctttt ccgtcgatga 2055421 ttgttgcagt cattttcttt cctcctatga ttgttcaata tcagatttaa tgttagaaag 2055481 aaccccgttt acaaactttg tcgctttgtc atcaccaaac cgttttgcca gctcaatcgc 2055541 ttcgttcatg gagacattca ccggaatgtc ttcggcatat gccatttcat atgctgccag 2055601 gcgcaaaatc gcacggtcaa cattggcaat ccgatcgagc ttccaattca ccagatgctt 2055661 ggagatcatt tcatccagct ggtcttggtg ttccaatacc ccgtgtacaa gctgttcaaa 2055721 gaaaggatct gttttttctt catccagtgc gtgttctatg gcttcattca ctgcaatatc 2055781 gctgacatca atttgaaata gtgcctgcaa agctttttct cttgctgttc ttcttttcat 2055841 tttctttctc ctttgatcct ctttatccgc ttgtcgttaa gccacaaaga gatcataaca 2055901 tatttttttc gtatccgcat attgaaatca aggttttttt accctattac cgaatatttt 2055961 cacacacctt aatatgatta ttcggatttc acgttcatga agaaactcgg ctatgtaagc 2056021 cggctttctt catgctttga aataaagggt aacgtgtaaa aaaaccaaag ggccgccctc 2056081 cccttggttt cgtgttaagc catttacatt tcttcgtcga tttggacttc ttgggctttt 2056141 gtgtcaaatt gaatgccgac gatgtgaata ttgatctcgt taatcgaaag agacgtcata 2056201 tttaataagg tttgacgaat gttttcctga acggatgctg caactttcgg aatcgaaacg 2056261 ccaaatgtaa cgacacagta tacatcgatc gtaattccgt catccgccag gtcgactttg 2056321 acacctttgc catgattcac tttgccaaag cgctcaacga cgcctgtcgc aaagtttccg 2056381 cgcatttcgg caactccatc aacttctgat gctgcaatgc cggcaatgac ctcaatgacc 2056441 tccggtgcaa tctcaacctt acccaaatgc gtatcttcgt gatccatttt aagcaagctg 2056501 ttgtctttca ttcaattcac ctccgtaaaa attatgagcc cattacatca tatgtttcta 2056561 aaaatttcgt attaaactct ccgctcacaa atgtttcgtg ttcaagcagt tttaaatgga 2056621 aagggattgt tgtctcaatg ccttcgatga cgaattcgct caatgcgcgc ttcatgcggg 2056681 caatcgcttc atctctcgtt tttccgtatg tgattacctt tgcaatcatg ctgtcatagt 2056741 acggtgggat ggaatagcca gggtacgcag ctgaatcgac acggacacca agaccgccag 2056801 gaggcaggta cattttaatt tcaccaggtg acggcatgaa atttttgctt gggttttctg 2056861 cgttgattcg gcattcgatg gcccagcctt caaattcaac atcttcttgc ttgaggctca 2056921 gttccattcc tgaagccact ttgatttgtt ccttgatcag gtcagttccc gtcaccattt 2056981 ctgtgactgg gtgctccacc tggattctcg tgttcatttc catgaagtaa tagcgctgtt 2057041 cattgtagtc atagataaat tcaactgttc cagcacctgt atagccaacc gctttggcag 2057101 cctttaccgc tgcatctccc atttgctccc tgatttctga atcaagggca ggagatggtg 2057161 attcttccaa aagcttttgc aggcgtcttt ggatcgagca gtcgcgttcg cccaaatgga 2057221 tcgtatttcc gtagttatca gcaagcactt ggatctcaac gtggcgaaaa tcttctatgt 2057281 atttttcgat gtatacacct ggattcccaa atgcagttgc cgcttcctgc tgtgtaatct 2057341 taatgccatt aatcagttcc tcttcagtgc gggcaaccct aattcctttt ccgcctccgc 2057401 ctgcggtggc ttttataatt acaggatacc caatttcatt agcaagcgaa accgcttctt 2057461 ccacattttc tataattccc tgtgaacccg gtacgattgg cacgccggcc tgtttcatcg 2057521 tttcccgcgc aacgtctttt gttcccattt ttgaaatggc gtcagcgctc gggccgacaa 2057581 acgtgacatt cacttcttca cataattcag cgaaatcagc attttcagct aaaaatccgt 2057641 atcccggatg aatggcgtcc gtgccagtca gctttgcaac actcacaata tttgtaacgt 2057701 ttaaatagct gtcttttgat gctttcggtc cgatacaaaa agcttcatcg gccatttgaa 2057761 catgaagggc atctttatca gcttctgaat aaacagcgac agtctcaatt ccgagctctc 2057821 tgcaggctct gatgattctg acagcaattt ctcctctgtt ggcgatcaat agctttttaa 2057881 tcatgttcag tctccttact ccgcttttac aagaaataga ggttgtccgt attcgaccag 2057941 ctggccgttt tctactaata cttcaacgat ttcgcctttc acttctgctt cgatttcgtt 2058001 gaaaagcttc atcgcttcta caatgcagac aactgtgttt tcatttactt ttgaaccggc 2058061 tgttacatac gggccagctt ccggtgatga agaagcataa aatgttccta ccattggtga 2058121 agtgatttta tgcagattct catcttgctt tggtgcttct tgggcaggtg ccgctgcttg 2058181 ctgcgcttgc ggctgaactg cctgcggagc ctgtgcttgt acaggtgctg ccggtgcctg 2058241 ctgcatgact tgaaccgtgc ctgcttcgtg ttttttcagt tttaaggata caccttcatt 2058301 ttcatatacg aattcgtcaa ttgtagactc gtcaattgct ttaatcagct cgtggatttc 2058361 tttgatattt aacattcaat cgcactccta tgtatgaaat ttcttttttt ataggttact 2058421 actaaaagta catactatgt tcatcttaca ggagcggact tttgaattca actctaatat 2058481 gacagcaacg caaaaagccc gcttgtttag cgggcttttt tccctcattc ttatttagag 2058541 ggttcaaatg tgacagcgac atctttcatt gttttgattt cttttgccac aaggtctata 2058601 atggctgtcg ccttcgattt agagtgtttg tctgatttga ctgtaatatt gattttatct 2058661 ccttcagcat taacaagcgc atcctcgtaa ccttgtgttt taatcagcgt ttccagctgt 2058721 ttttctgttc cttccacttc actgagagcc gtcattttat cgtatgcttc gcttttctcc 2058781 ttggctgttg catcatcgct tgacacaatg gcattcagct cttctctttc tttgcttctg 2058841 gcatcttcta aatcaagacg gtacgttgta aacaaatcat catcggctgt ttccgtaaca 2058901 acagttcctt tttcactggc ttcagcggat gtttccttgt ctgctgatga atctttcgtt 2058961 ccctttgttc catcttcttt tcctttttca gtttctgtac cgcttttttc cttcgtgtct 2059021 tgcttggcag gcgctttttc agttgcgacc tctccgctgt cagacgcgct tttttcactt 2059081 tgcatctgca cggcgttttt gctttccggc gacatgatat agtagacgct taacaccacg 2059141 acaagactga gcattgttaa tagccaaacg gtttgttttt taagcattta tgaatcctcc 2059201 tttatttttt taggggcaac cgcaacccgg tggcttggaa catccaggac ccgtgtcacc 2059261 gcttcgataa tggtttgttt tatttgaacg ttgtccactc cttgagcaac aacgagtaca 2059321 ccgcgtatat caggtttttt cgtttggacg acgacaggtg tttctttatc gccgtttttg 2059381 atcatgacga tttcttcctc cgatgattgg tctgtaacgc ttctttttcc gccttctttg 2059441 tcagtttctt cagtggttgt atttttgttt gatttgtttt tttcgtatac tttcagcgac 2059501 gttgcatcta cattcacgac aaccgagaca tcgtccacac caatgattgt ttcaagaatt 2059561 tctttcagtt gattttcgta ttctttttca tagtcatcga tcgagtcttt aggtttatca 2059621 gattttgagg ctttaaacac ttcggctgtt ttctctttgc tgtctgcgga atgttgtgat 2059681 gatacggccg ttatcgtttt ggcgttttca gttttctcag gtgaagaaaa cagctggctg 2059741 acaagcataa aggaaactcc gagaacaaaa acgaatagaa agtaatgata tttggtcagc 2059801 ttcggctttt cgccgtcctt cgtttgtccc ggaagaaact gctttttcaa tacattccat 2059861 aatccgtttt tattcattgc cgacactctc cccgccttcc atatgaaccg taattttctc 2059921 acttccgatt tcccaaatgt ccgcgagctg cgtttgtatc tgtttggctt ctttttgttc 2059981 ggctgcttct tttgttacgt atgcatgatc tgtatcaatg tggaccggcg cgaccgtttg 2060041 gaccgttttt tcagaagacg gggccatata cacgctgatt gttttaatat cctcttctga 2060101 atctaccttt tctcctgccg tgagtttgat gcggcctact ttatattcat catgactgaa 2060161 tctctcctcc gctttctttt ttagttggac agccatttct tctagaatat atgcgcgctg 2060221 ggaagcttgt atttctattt tttttgaatt gatttgattt tttatgtcgg cagactctga 2060281 ctgcccgttt tttgtgaggt attcaaagat gacttcgggg tctgtcttga aaagtttaaa 2060341 aatcggcgta agcatgacga caatcaagag caggctgact accatttttg cgtacttttg 2060401 catgctggag ctcggcagca gcatatcaat cacaattgca aataggataa acaacacgat 2060461 ggtggtaagc cattccgtta aaaaactcat ttgcctgcct ccttcatttc atcatcatcg 2060521 tgaggtttcc ggctgtgatt atgacagtaa ggcttaaaaa aaacatgaga gacacaatgg 2060581 cgagagctgc aaaaatataa atgacgcttt tgctgatgac gtcgaggcag gtgatgacgg 2060641 gcccgcctcc tagcggctga agaatcgcgg ctgccagctt ataaataaaa gcgagggaaa 2060701 gcactttgat tgccggaaat gccgcaatac agatcaaaat agcgacaccg agaatcccta 2060761 ccgtattttt cagcagtaaa gaggcgctga ttactgtatc tgttgcgtct gtaaacattc 2060821 ggccaagcac aggaataaaa tttccggtta taaatttagc cgtcctgagc gtaatgccgt 2060881 ctgtcactgc agctgacgct ccctgaacag agatgacgcc gagaaagatg gtaagaaaaa 2060941 cagccagtgc tccgatggcg atatttctga gcaggttagc cagctgcgtt actttgtatt 2061001 gttcagtcat cgtgctgaca atgctcagaa tcgctgataa aaaaatcagc ggcatgacga 2061061 tattctgaat caagagaccg ctcgtgttca tcaggaagag gataacagga tgaaagaagg 2061121 cagcagatac agctccgcct gaggaagcca aaagcgccaa gaggagcgga atgagcgcca 2061181 ggataaagct ggtcatcgtc tgaatcgcct cagttgcata gttaattgcc acatgaaagc 2061241 tattaagcgc aaggataatc agcaccatgt acacaattga gtaagcgacc ttactgacgg 2061301 tgctttgctg aaaagcattt tgcaaaagct gcagaatgac gcaaaaaatc gtgagcaaaa 2061361 tcaatgtgcc cagcagcttt ccgttggcaa gcacttcatg aaacaaataa gaaaagagag 2061421 ctttcagcca ttcttgcggt gagaatgatt tatcgccatt gataaactcc attaagctgc 2061481 ctttttggct ttccggcagc agtccgccgt attctgtcat aatgtcattc caaaattccc 2061541 cgatcttatc tgtttcaagc gaggctgctg tcctttccgc taattgctcg gctgtttcag 2061601 catggtcttc cgtttgttct gcattaccag ctgcttgtac aatttctgca cggcctgcta 2061661 tgatcagcac ggccaaaagc aaaacccatt gaaagcgctt caatctaccg cctcctttcg 2061721 gttatgacat agaaggtata agtccgagaa tcgtttcgat aatgacggtt aaaataggca 2061781 cagccattac gagtattaaa attttccccg ccaattctat tttcgaggcg atggctcctt 2061841 gaccggcatc ttttgtgagc tgtgccccga attcagcaat ataggcgatt ccgataatct 2061901 ttaaaatggt ttcaacatag accatgttga catttgcatt aatcgcaatt ttttctatca 2061961 ttcgaataat gtcgtagatt tggtctacca aataaagaaa aatggcacat ccggcaaaaa 2062021 cgacgattaa aaacgcaaaa gtcggctttt gttcttttac aattaaagaa aggaaggtgg 2062081 cgatcagccc taaacctaca atttgaacaa tgtcaatctg caagcccccc tatccttgga 2062141 ataaaaacac agcttttatc tttttaaata ggtcatctac aatcgtggcg accataaata 2062201 aaatatagat aaaacctaac agcgtcaccc actgagcata ttctttcttg cccatctgat 2062261 ccaatatcgt gtgtaaaaaa gcgaccacga ttcccactcc ggcgatttga aatatgacat 2062321 tcacgtctac tcccatttta tttttgctcc cctcacgttt acatcaatag aagaatgagt 2062381 aacaagcccg ctaaaaagcc caaacttttt atcatctttt cgtttttcgc ttgcgcctgc 2062441 tcagcatccg cttctgaggc ttccaaatgt gtcagcgcca gcttgatgtg cttttgctga 2062501 gagattcgat catgaatccc aagcgtctcg ccaaactgct tcagcacttc gtattcgctt 2062561 tttttcaaag acagggtgtc ccataccttc tttaagcttt gctcccacgc cgttttcgcg 2062621 gaatcacttc ccttgtccag ctgatcactg aatgcggaaa aaagagttga aacaggctgt 2062681 gcgagctgtt tggcaatctg ctgtgaagca gtatgaagcg gtgtatggcc gtacatgatt 2062741 tcagcctcga gggattgaag cgccgcacgc agctggcgga tttgccgcgg ccgttctgta 2062801 taaatcttcg ccatctcaaa acctgtccat gttgtcgcta ccacaatgaa tacagcgccc 2062861 agcagcttca gcatgttttc acgcccgtcg tcctagacag cacatttccg tctttgtcat 2062921 aaatttggct cactgtgccc ggcccttttg ctcttgataa ttccaaatag cggtcaaagg 2062981 ctctttcttc ccacaaacgc ttcaatgaag gccgcttcat caggtcggat atactccagc 2063041 catgcgccga tacgattact gaaacaccgg catgcagcgc ctccagaagt gcatctgtat 2063101 cttccatacg cccgatttca tcgacaatca tcacctcagg gctcatggat cgaatcatca 2063161 tcatcagccc ttcagctttt ggacaggcgt ctaacacgtc aattctctga ccaaattgat 2063221 gctgcggaat accgcgaaga catccggcaa tctctgaccg ttcatcgacg atccctgtct 2063281 ttacgggcag catgtttttt ttgccggtgc ttgagagcct cgcaaggtcc cggagaagtg 2063341 ttgttttgcc ggtttggggc ggtccgataa tcagcgtatt cagccagctg ttttgatata 2063401 agtatggaag cagcggctcc gcaatcccca gcttttgccg ggcaattcgt atattaaaag 2063461 atgcgatgtc acggaggcct ttcacacctc cgttttccgt aatgactctg cccgccagtc 2063521 cgactctgtg gccgcctctg atcgtgacat accctttctt cagctcttct tcaagtgtat 2063581 acatactata gttgctgagc cggctcagga tcagatgggc atcctcggcc gtgcccgcat 2063641 aggacaaata aacaggttgt cctcttcgaa tcaattcaac agggcggttg atccgaattc 2063701 tgacttcttc gatttccagc cattgttgtt ccggtatttc agaaagggcg tttttcatgg 2063761 attcagggag aacctcagcg atttcattca acagagcctc ctcctttcta ccgattggct 2063821 tctttaaaat gtatgatgtg aggcagactt tatgacaagc ctctctttat ttatgaacac 2063881 ccgccaaaat caagacaaca cccgtaaaaa tcagaatcag ctttgcatac gaaagctgcc 2063941 cggcaatttg gtagattccg acagtcattg taatgataaa aatcaacgga ccgacaatag 2064001 cgagaatgct gttaaccaca accgccttcc ggacatcgtt ggtcacaagc atgacaattg 2064061 ctgccgtcag ctcaatcata gaggataaaa ctcgtaatcc cgccattgtt aaaacagtag 2064121 aattgatatt tccaagtaaa aatttcatag cactctccca acctcccatt tttttatatg 2064181 atatgctcta gcttgctgaa gtagtcttgt cattttcgta taaaagaaag attctgtttt 2064241 tgggcacaaa aaaagcctgc tcccatttgg gaacagactt ctttttttct ttctatgctc 2064301 ttgaaacgta agaaccgtct gatgtattga caacaagtgt gtcgccttca ttcacaaaga 2064361 acggcacgtt tacaacaagc ccggtttcag ttttcgcagg ttttgtaccg cctgacgctg 2064421 tatcaccttt aataccaggt tcagtttcaa caactttcag ctcaactgtg tttggaagtt 2064481 cgataccaag tgtttcatcc tggtacatca tgatatgcac agacatgttt tctagcaggt 2064541 attttaattc ttcttcgatt tgagttgcgc tcagttcaag ctgctcataa gaagaagtat 2064601 ccataaatac gtgctgatct ccgtttgcat atagatattg cattgttttg gtttcgattt 2064661 gcgctttcgc tactttttca ccagcgcgga atgttttttc ctgaatcgcg ccagtgcgaa 2064721 ggttgcggag tttagagcgg acaaatgccg caccttttcc aggttttacg tgctggaagt 2064781 caacgacgcg ccaaatgccg ccatctactt caattgttaa tcctgtacgg aaatcgttaa 2064841 ctgaaatcat gtttaatgtc ctcctatatt ccaatcacaa aataataagt tcttttgggg 2064901 aatgggtgat tgtccggttg ccgttttctg taatcacgat gtcatcttca atgcggacac 2064961 cgcctgtttc tggtatgtaa atgcccggct ccactgtgac caccataccc ggttcaagga 2065021 tagctgaaga tctgacggat aatcccggcg attcatgaac ttccatgccg agcccgtgcc 2065081 cggttgaatg gccgaaatag tcaccgtagc cttttgcagc aatatgatcc cttgtgaggg 2065141 cgtcagcctc ttttcctgtc attcccggct taatatgtgc gacgccaagc gcctgagcat 2065201 caaatacaac ctgatagatc tccttcaatt gatcactggg ctgacctaca gcgaccgtcc 2065261 gggtaatatc agaacaatat cctttataat aagcgccaaa atcaagcgta acaaggtctc 2065321 cgctttcaat cagtttgtca ctggccacac cgtgcggaag gcttgaacga aggcctgagg 2065381 cgacaatcat atcaaaagaa gagctgtctg ctccctggct tctcatataa aactccagct 2065441 cattggcaac agcgatttca gaaatgccgg gtttcataaa cgtcaagata tgtctgaagg 2065501 catcatctgc aatcttcgca gcttcctcta atatcttaat ctcttcacta gacttaatca 2065561 agcgcaactt ttccacggat tcagccacag gcactaattc ggcatcactg ataacggcgc 2065621 tgtatgaagc gtaagtgcca tatgtcatgc tgttctgttc aaagccgaga cgcttgatgc 2065681 caaacgattc aacagtgtcg gcagtggtct gaatcaagct gccgccatgt tcaatgatct 2065741 caaaaccctt tacctgaacc ttcgcctgct cagtataacg aaaatccgta ataaacgctg 2065801 ctttgtcacc cgatataaca gccaaacccg ccgaacctgt aaaccctgtc atatagcgta 2065861 cattagtgtt gcttgtaatc agcatgccgt caattcccag ctgtccaaac aggtttctta 2065921 atttctctag cttcatcttg attctccccc ttgctggctt aataagtagc gaacagcaag 2065981 cttgtagcct tcagctccaa gaccgacaat ctgccctttc gcaacaggag cgataaccga 2066041 ctgatgcctg aattcttccc tggcgtataa gtttgataaa tgcacctcta ccacaggaag 2066101 actgatgctt gaaacagcat ccctgatcgc atagctgtaa tgactcaggg cgccggggtt 2066161 cagaacaatc ccgctgtatt gctcctcagc ctcatgtatc gcatctatca aatcaccttc 2066221 gtgattagac tggaagaaag tgagctggat atgtaaggct tcagcaaact gaaaaagatc 2066281 tgtttcaata tcggtcagtg tctggcggcc gaatacttca ggctcacgac tcccaagccg 2066341 gttaacattc ggtccgttca aaatcaaaaa atgaggcaca caatctctcc ttttcgcgag 2066401 ggtttctcat gtaaaaaatg ttcacttctc gtgaacattt tatcatactg gaaaaggatt 2066461 atacactatt ctctatgcat tcccagcgca cgtgcaagct tttccgaatt cagctcattg 2066521 tattcaaatg aaatagaata cccgacaaac agcccgtaaa gcaaataaat gcaaatggtc 2066581 gtaataattg tatctgatgt cagttcggtc accgtgcgca catctggaaa aatcggatta 2066641 aaaacaaaaa acacgagcag ccaaagcacc aagccgtata aaatacccgg ccacattgtt 2066701 tttaaacgtt tcaatagaag aaaataaaga aatgctgcgc caattgaaat tactccaatc 2066761 aaaatgatgc tgattaccgt tcccagccca tgttttttcc actctccgag tacaaacggc 2066821 tgcaatatca tattcgggct gatttcggaa aaatgaaaca aatatgcgat ataagcaacg 2066881 aaactccaaa gtacgcctcc gcaaaaacct gttgccgcca ccctgccggc cattgaaaca 2066941 ggcggctttt gcttctcatt caattcttca ttttgttctg tatctttttc gcttgtcatc 2067001 atggcacctc cagttaaagt gtgcccaaaa aatgaaatgt caataaaaaa gctcacactt 2067061 tttggcagct gcgagtaaaa tttgaaaata acgggtataa tgcatgtaga aaaagcaagg 2067121 ctatggcaat tttttcagcc tgtcaatcta gaggtttagc gctgtttcct gtacaataga 2067181 gtgaaaggaa atggttagca atcctaaaga aataggcagg ttgataatat gtcaaaacat 2067241 aaagttccgc ccgcttacgg cgggcaggct gttgtggaag gcgttatgtt tggcggaaag 2067301 catcattacg ttacagccat cagaagaacg gatggaagca ttgacttttt taagcttcca 2067361 cgcaaacaca acccgaaact gaacatcgtg aaaaagatac cgtttttacg ggggatcgcg 2067421 gccattatcg aagcgagtgc aaacggcaca aagcatttga atttttcaag cgaacgttac 2067481 gggctcgatc catctgaaga cgagacactt gagcaggaag aaaaaaaatc ctctgggctg 2067541 tctatgtatc tcagcctcgc agttataggc gtcctatcat ttttgttcag taaattcgta 2067601 tttacattgg ttccagtttt cttagcggaa ctgacaaggc cgattttttc cttgaacaca 2067661 gcgcaaatcg cgattgaaag cctgtttaag ttgattttgc tgctcggtta catctatttt 2067721 ttgtccatga caccgcttat taaaagagtg tttcaatatc atggagccga acataaagtc 2067781 ataaactgtt atgaacagaa tttgccaatt actgtggaga atgtccaaaa ccaatctcgg 2067841 cttcattacc gctgcggatc aagctttatt ttatttacga ttattgtcgg catgtttgtt 2067901 tatttactcg ttccgacaga tccgctttgg ctgcgtgtta tagatcgtgt cgcactgata 2067961 ccggtcgtgc ttggtatatc ctttgaagtt ctgcagctga caaacaaagt gcgtgacatt 2068021 cccggtctga aattacttgg gtacccggga ctttggcttc agctgttaac cacaaaggaa 2068081 cctaaggatg aacaggttga agttgccatc gaaagcttta acgaacttct cagactcgaa 2068141 gcattgtctg agcaaaatca gaagccttct cacaacgtca tctaaaatcc gttgccctgc 2068201 tattactttc ggaggtggac agttatgaat catcgtgtac aacctattat tgctgtatta 2068261 attgcgctgg gagcgttcgg tttcctctat gtgctggtaa ccaatcccgg agaaatggca 2068321 aaaatggcgg taaccgtcat cgtggcaggt atcattattt attttattgt gaaatatgta 2068381 atgaatcgaa atgcgggcag cgaaggagca gccttcaaaa aagcggcgaa acaatcacgg 2068441 cgccggatga aagaacaaaa agcaaaacac cgcgccggac ataagggacg tgtcagccac 2068501 ctgcgaagcg ttccgagcgc cagcaagcct aagccgatga ttctcaagaa aaaaagccag 2068561 actcagctga ctgttataga agggaaaaaa aataaaaaga aaaacagagc gcttttttaa 2068621 taggtccact gctttaaaaa cagctctgtc cgtcttttac ctagctcaat cagggctagt 2068681 tttttttgtt gtgttaaatg aaaatcagtg gccattacgt catcaacagg gagaaaaatg 2068741 atattttgtt catagcgtga cgcaatgtgc cttgcgtcat gagcatcctt catcgtttca 2068801 aacagggcgc cgaacagttc aaaagcgttg cggatatttt ttttcggacg ctctctttca 2068861 cgcggcgcaa gcgtgacacc gatcacaggg cgctttcttt cctttgaaaa cagccagatt 2068921 ggaaaattgc ttaacacgcc tccgtcgaca accgtggcgg tgcctgtgtc cgtttttaat 2068981 tttatcggtt caaagaaata cggaatgctg cagctcattc tgaccgctct ggcaaccggg 2069041 aacatatctg gatttaaccc gtaacgggcc aaatcgtccg gcaaaacaat catggtgccg 2069101 tttgtcagat cagaagcaat aaggcgcaga gaccctttct gcaaatcgcc gaaaaccctt 2069161 atgcctttcg ctcttaacag atcagcaatc catttttcta tcgtatcgcc tttgtataag 2069221 ccaagacgcc agtagatgga cacccactgg agcatcttta aggggagaaa tgagtacctc 2069281 tgatccagca atttctctcc gtccacttct tcaattaaag cgtggatttc cttactggtg 2069341 taacctgacg caatgaaagc ggcaataatg gcgccggcgc ttgtacccgc aactctttta 2069401 aagcggaagc ctttttcctc aagcacttca taagcgcctg cgagcgcaat gccttttact 2069461 cctccgccgg aaaacacacc gtcaatatac atctcattcc ctccccctcc atccgatcgt 2069521 ttattaccat tttaagaaaa cacgcgaaga aatagaccaa cgaatgacgg gtggcgtcag 2069581 cgtatcaaaa aagacggcct ccttcgagac cgccttttta ctgattatga tgttctgttt 2069641 tcttttggat tgatttcaga tcttttttac gggcatcatc ttcttcaaaa tattgaacaa 2069701 gatccccgat gcgatcaata ctgttccagc ttaaatgatg ttcgattcct tcgacatcgt 2069761 tatatatttt ctcttcatca acaccaatga ttcttaaaaa ctgctcaagc aattcatgtc 2069821 tgtataccag ccgtttgcct atttttttcc ctttagacgt taacacgaga ccgcgatatt 2069881 tttcataaat taaatattcg tctttatcta gtttttgaac catttttgtt acagaggagg 2069941 gatggactgc caatgcttcc gcgatatcgg aaactcgtgc atatcctttt tcttcaatca 2070001 gcatataaat ctgttcaata taatcttcca tacttggtgt tgtcatcgaa accctcccaa 2070061 aaagcacctt aactttataa accattacaa gtttacacta atgaacttga aaaaacaagg 2070121 atgctccgcg ggtcaaaagc cctgtttacc gcttataatt ccattcatct gaagcgtact 2070181 ttgtttcagc caagtgatga acaaaatcaa gctcttcctg agaaagttca tatggctcca 2070241 aatgaatgtt aagacctgtt tcaaatcctt ctttaaaggc tttacgagcc tcatccatcg 2070301 tcacccgctt ttcgatgagt tcattaatgg caaccgcttt atttttgaaa ttgcgctgca 2070361 tccgctctct tactctttca cttggatata agaacagatc gaacagcttg tcctcatcta 2070421 aatcaagaag aatggagcca tgctgaagaa tcacaccttt ttgtctcgtt tgcgcgcttc 2070481 ccgccacctt gcgcccctca accactagtt cataccacga aggcgcgtca aaacaaacag 2070541 atgaccgcgg attttttaag ctttcttttt ctttttcagt tctcgggatg gcaaagtaag 2070601 cgtccagacc gagatttcta aagccttgaa gtatgccttc tgaaataacc cggtaagcct 2070661 cagtaacagt cgccggcatc tcggggtgct cttccgaaac aattacgctg tatgtcagtt 2070721 cctgatcgtg cagcacacct ctcccgccgg tcgggcgtct gacgaatccg agattatatt 2070781 tatgtactgc ttcaaaattg atttcctttt taatattttg aaaataccct acagaaagtg 2070841 tcgccggatt ccagccgtaa aaacggataa ccggggggat tttcttttcg ctgtgccaat 2070901 ataaaagcgc ttcatcaagc gccatattga atgcaggact tgcattgcct gagtctataa 2070961 accgccaagt ttctttttgc attttaagac cttccttacc gttttaatag aatcagttta 2071021 tcaaactgtc gggaaaatga aaaatatttt agttccatta tagatgacaa tcacgctgtg 2071081 ctttactata atagtatttg tcgaaaacgg ctctatgacc ttgttttatg aagcagggtt 2071141 ttgattttat atgctaaagg agtagaatca cattgtctaa tatgatcgtt ttgattattt 2071201 ttgctgcatt tatcatctat atgattgctt catatgtcta tcagcagcga attatgaaaa 2071261 cacttaccga agaagaattc cgcgcgggtt accgcaaagc gcagcttatt gatgttcgtg 2071321 agccaaatga gtttgagggc ggacatattt taggcgcccg caacatcccg ctttcccagc 2071381 tgaaacagag aaaaaatgag atccgtacgg acaagcctgt ttacctgtac tgccaaaaca 2071441 gtgtccgcag cggacgcgcg gcacaaaccc tgcgcaaaaa cggctgcact gagatttaca 2071501 acctaaaagg cggctttaaa aaatggggcg gaaagattaa agcgaagaaa taaagcaaac 2071561 agctgtctgg tagacagctg tttttattta tctttcttcc gcctcgtatc tgagcactgg 2071621 gtgtctcgcc gcttttgttt catccattct ttttacaatc gttgtatgcg gggcctcctg 2071681 aacaagctcc ggattctcct ccgcttcttt tgcgatttga atcatagcat caataaacgc 2071741 gtccagtgtt tcctttgatt cggtctctgt cggctcgatc atgatgcatt cttcaacatt 2071801 aagcgggaaa taaatcgtcg gcggatgata gccgaaatca aggagccgtt ttgcaatatc 2071861 aagcgtacgc actcccagct ttttctgccg cttccctgat aatacaaatt catgcttgca 2071921 atggcggtca aacggaagat cgtaataagg cgcgagtttt ctcatcatat aattggcgtt 2071981 taacactgcg ttctcagtaa cagcctttaa tccgtcaggc cccatggagc gaatatacgt 2072041 atacgctctc acattaatgc caaagttgcc gtaatacggc ttcacacggc cgatcgcatg 2072101 agggcggtca taatcaaacg taaagcgccc ttcttttttg actaaaactg gctttggcaa 2072161 ataaggaatc agatcttgtt ttacgccgac agggcctgag ccggggcctc cgccgccatg 2072221 agggcctgtg aatgttttat gcaggttgag gtgcaccacg tcaaatccca tatcaccagg 2072281 tctcgccttg cttaaaacgg catttaaatt agcgccgtca taatacagtt tcccccccgc 2072341 ttggtgtaca atttccgcca tctctgtaat ctgctcctca aacaagccga gcgtgttcgg 2072401 attcgtcagc ataagagctg cagtttcttc attcactgct ctttttaaat cctctaaatc 2072461 aacaagccct ttttcattcg atttcaccgt aacggtttca aagcctgcta ctgttgctga 2072521 tgcaggattc gtcccatgcg cggaatcagg gacaatgacc ttcgtccgct tgaaatcccc 2072581 gcgagcttca tgataggcac ggatcatcat cagccccgtc cattcgccgt gcgctccggc 2072641 agcaggctga agcgtaacct catccattcc cgttatttct tcaaggtgtt tgcttaaatc 2072701 atataaaagc tctaatgcgc cttgcaccgt gtcttcatcc tgaagaggat gaatcgcagc 2072761 aaaaccagga atacgtgcga ttttttcatt gattttcgga ttatatttca tcgtgcaaga 2072821 accgagagga taaaaaccgg aatccacccc gtgattgcgt ttggacagcg ctgtataatg 2072881 gcgcatgatg tccagctctg aaacctccgg cagcgctgcg tcttcgtcac gaatataggt 2072941 gtctgacaag aggtccccca attcgatttc cggtacatcg agctccggca gactatagcc 2073001 gattcggcct tctcttgaaa gttcaaaaat aagtgcctgg tcctgattac tcatggcgat 2073061 cccccaattc ctgaatgagt gcgtcaattt cttcttttgt tctcagctct gttacagcaa 2073121 tcagcatatg gcagtccagc tctggatacg tcaacccaag atcatatccg ccaatcatgc 2073181 cttttgccag caaacgcttg ttcacagctc tcaccggctc atccagtttg atgacaaatt 2073241 cattaaacat cggcccgtca aacataacag taaggcctgc tttttttgct tcttgctttg 2073301 catagttggc ttttaagaga ttttggcggg ctatatcttt tacgccgttt tttccgagag 2073361 cagtcatggc cactgatgct gccagcgcat ttaaagcttg gttcgagcat atatttgatg 2073421 ttgctttatc ccggcggata tgctgctccc tggcttgcag ggtaagcaca aagcctcttt 2073481 ttccgttttc gtcttccgtt tgtccgacga gacggcccgg cacctttctc attaattttt 2073541 tagtaacggc aaaaaagccg caatgcgggc cgccgtatgc tgaaggaatg ccgaaaggct 2073601 gcgcatcacc gacgacgata tcagactgaa acttgcccgg cggagtgaga agacctagcg 2073661 ccagcgggtt ggctgaaaca ataaacatgg atttcccttg atgagcgata ggctcaatat 2073721 cctttagcgg ctcgatcctg ccgaaaaaat tcgggtactg aacgatcact gcggctgtgt 2073781 tctcgcaaac ggtttggcgc aatgcatcaa gatccgtaac gccatccgca gcgggtactt 2073841 caacaacatc aatatactga ccttttgcgt aagttttcag cacctctcgc gattcaggat 2073901 gcacggtttt tgacacaaca atttttttct ttttcgtgtg gcctgaagca agcattgctg 2073961 cttctgccaa ggctgttccg ccgtcataca tcgaggagtt ggcgatatcc atgcctgtca 2074021 gttcacagat catcgtttgg aattcaaaaa tagcctggag ctctccttgt gaaatctctg 2074081 gctgataagg cgtatatgcg gtataaaact cagagcgcga aatgacatga tccacaatga 2074141 caggctgata gtggtcatat acacccgctc ctaagaaaga agcgtattgt acggtatcac 2074201 gatttttaga ggccagcttt gtcagttctc ttgttaattc tgtctctgat ttcgcttttt 2074261 tgatttgatg ctctttttta tatttgacgt tttccggtat atcagcaaat aaatcatcga 2074321 tgctgcttac gccgatagta gcaagcatct cctgtttatc cttttctgtt gcgggcaaat 2074381 aacggtgctt catgtgttgt ctcctctctc caagaaaaaa tattagcgtt tataaaatgg 2074441 tgttttgaca acctttgctt tcactaattt tttgcgtatc tctacatcta caacagtccc 2074501 gatctcactc gtttccgaat caattaaggc aaggccgacg ttttttccta atgtcggtga 2074561 ctgcgtgccg gttgtcacct ttccgacaga cttgccattt tggaaaacct catatccgtg 2074621 ccgcggtatc cctttttcaa tcatttcgag accgacaagt ttgcgcttcg ctccgttttc 2074681 tttttgttca ctcaatactg acttaccgaa aaagtcagac tcctttttgt gctttacagc 2074741 aaagcctata cctgcttcaa tcggtgtaat atcccgggtc agctcctgac cgtagagcgg 2074801 gagcttcgct tcaaaccgga gtgtatcacg tgcaccgaga ccgcatggaa tcaatccgta 2074861 tgcatcccct gcatcgatga tttttttcca aatatgcata gcatcatcac tgcggcagta 2074921 aatttcatac ccgtcttctc ccgtatagcc agtgcgtgaa ataagtgctt tgcggccgct 2074981 gatatcggct tcatcaataa acgcaaacgg ctttaatgca gacacatccg catctgtcag 2075041 attttttaag atcgcttctg ctttcggtcc ctgtacagcc aagagcgcga tttgatctga 2075101 ctgattgtca atctgcacat cacctgctgc atgttctttc atccaagcca agtctttatc 2075161 tatattagaa gcattaatga caagcagata gcggttctct cctttttgat agataagcaa 2075221 atcatcgacg gttccgccat ccgggtaaca catcgctgta tattgagcac ggcctggcgt 2075281 taacgcggaa acatcatttg tcatcaatct ttgcaaaaaa gacagactgt cgttccctga 2075341 cacttcgact tctcccatat gagatacatc aaacaaaccg gctgcagttc ggacagcctc 2075401 gtgttctttt tttatagaag aaaattgaac aggaagctcc cagcctccga aatcaatcgt 2075461 ttttcctcca tattccttat acaggtcaaa taacggcgtt cttttcagca tctaattcct 2075521 cccctttatc aacggcgcag ctaaaaaaca tacaaaaaag gacagagaaa cacctcatgt 2075581 aaaatgaagg ttctctgtcc tggcacctga aagtttactt tgcatacgca aagacgtccc 2075641 ctttggtggt ttgcgcatcc gcacaaacac tctccagagt tgcgtcgagc aagagttctt 2075701 ttgcctgaga gattcactcc gcagtttgct ccttcggcgc ctgtatcccg aggttttcgg 2075761 tcaggtctct ccccttgctg tcattcgctc atattttcat gctgttatgg acatactata 2075821 gcaatatctt acatcaaata catactcata tcctaccatc atcactatat gctgggcaac 2075881 agcaatttgg gcagattttt cttatattat tcatcttaag aatcgaagaa taagaaaggc 2075941 ggtttcaaag caatgaatac agaaatgatc tacgatgcaa aatggcctga agaatttgct 2076001 gaaagactga aaaacgatgg cccttgggca aactgggaac tgtacaagct ctctgcagaa 2076061 atccagaaaa cattagcaat tccagagttt gaaggcttac gggctccttt atatctgcct 2076121 tcctttacgc cgctccccca ccagcttgaa gtggcgcaaa aagtggttga aaaaatgaac 2076181 gggaaagcga ttttagcaga tgaggttggt ctcggaaaaa cggttgaagc tggactgatt 2076241 ctaaaagaat atatgattcg cgggttagca aaaaaaattt tgatccttgt gcccgcttcc 2076301 cttgtgtcac agtgggtcaa agagcttcag gaaaaatttt tgattccggc tgttgaacaa 2076361 aagaaaagct atgtgtggga gcaatgcgat attgtcgtct catcaataga caccgcgaag 2076421 cgctcgcccc atcgagaaat cgttctgtct atcccatatg atcttgtcat tattgatgag 2076481 gcacacaaac tgaaaaatag caaaacgaag aactatgaat ttgtccggaa tctcgtaaaa 2076541 aaatattgcc tgcttcttac cgcgacgcca atccagaacc gtatcgaaga gattttcaat 2076601 ttggtgtcct tattaaaacc cggccattta ggcagtcaga atcactttca ggaggagttc 2076661 gccaagaaga aatccagttt agaagcgcat gaacatttaa aagatcttgt gaataaagtc 2076721 atgatccgta acaggcggca tgatacaggg ctgaattgga aacagcgcca tgttgaaaca 2076781 gtgccgattc aattttctcc atcagagcag gcgctttatg atgaaatttc tcgtttgaag 2076841 gacagtatca ataaaccagc cagcatgttc tcgattatga ccttgcaaag agaatgctgt 2076901 tcgagcagag aagcggtata tatgacgctg aaaaagatgc ttgatcaaaa agagaaacaa 2076961 gcacctgcca ttgatgagga tacgatttca gttttgatag atcgcatcaa tcaagtgaca 2077021 caaaactcta aagcgcttca agttgttgac ttgatcaaaa agatcgacga taaggtcatc 2077081 atttttacag aataccgcgc aacccagatt tatctgcagt ggtttcttca gcaaaacggc 2077141 atcagttctg tgccgtttag aggcggattt aaacgtggaa aaaaagactg gatgaaggat 2077201 cttttccgcg gaaaaatcca agtccttatt gcaactgaag caggcggtga gggaattaac 2077261 ctgcaatttt gcaatcacat gatcaactat gacctgccat ggaacccgat gcggcttgag 2077321 caaagaatcg gaagaattca cagactcggg caggagcgtg acgtgcatat ttataacatg 2077381 gcgacaaaac atacggtgga agagcatatt ctaaagcttt tatatgaaaa aattcatttg 2077441 tttgaaaaag tggtcggtga acttgatgat attttaacga aaattcaagt gaacaatttt 2077501 gaagagcacc ttcatgacat tttgtatcac tcagcaacag aagaagaaat gaaaataaaa 2077561 atggataact taacctcatt tttgtcttat aaaaaacagc tgcctgctga aaaaagagga 2077621 tcttagcctg taaggaggtt ttattagtga gacagcaaga ggttcacgat tttctgctgc 2077681 gtttttttca agcaaacagc tgccaaatcg tcgatcaagg cttaggctat atgacagtgc 2077741 agcttacagt tgaaatggac aaacaaatca tgaaccgccc tttctactgg cattggcgcg 2077801 agaagacagg cggtgatccg aatccaatga aaatcacttt tattacagat aaagaaaatg 2077861 cgccaaaaga cctagatggt gaatttatat attttggggc cccgcgtctt tttcaaatat 2077921 tcaaagctgt taaacaaaat gggagattta ccagaatgta tgagaaaatt gaatcagccg 2077981 gagctaaagt cccacttcag ccttggcttg gtataaatgt cacgatttca taccagtccg 2078041 acatgaaaaa ggataagtta ttgtcactag gtcttcacct agtctctgga acgataattg 2078101 aagattttca aagcaagctg acccagtttt cactgacgtc tcaaatatgt gactattgct 2078161 tcaccatttc acctatgatc aaaccagaaa gcggacttaa gcgtatggaa aactatattt 2078221 ccaaatccgc tatgcaggag ccgtccgact gggcggaaca ggcggttaac aggtggaaga 2078281 atgatatgac attgcttgat aagttttacg agcatataga agaaaaacca gaagaatacc 2078341 atctagaaaa acaggcgctg aaaaccttgt atcaaccaaa gatatcagtt gaaattgaaa 2078401 atggcggatt gttttatctg caaaataata tttcaagcta acttttttac cattcgacat 2078461 cattctcgtt ttttttgaga aaatacgatt ataataaagg tatattggaa aaaaattctg 2078521 gtgatttaat ggcaaatgac ttccagagac taatgaagca tacaataagt catggccgga 2078581 ctggctgaaa tacataaaca agtattttag gaggagaaac tgcatgaaga atgcaaaaca 2078641 agagcacttt gaattggatc aagaatgggt tgaattaatg gtggaagcca aagaggcaaa 2078701 tatcagcccg gaagaaatac gaaaatattt acttttaaac aaaaagtctg ctcatcctgg 2078761 tccggcagcc agaagtcata ccgtaaatcc tttctgaatg tgctataata tcacaaggaa 2078821 ggtgatgaca ttgattggcc agcgtattaa acaataccgt aaagaaaaag gctactcact 2078881 atcagaacta gctgaaaaag ctggggtagc gaagtcttat ttaagctcaa tagaacgaaa 2078941 tctacaaacg aacccctcca ttcaatttct cgaaaaagtc tccgctgttc tggacgtctc 2079001 ggttcatact ttgctcgatg agaaacatga aaccgaatac gatggtcaat tagatagtga 2079061 atgggagaaa ttggttcgcg atgcgatgac atccggggta tcgaaaaaac aatttcgtga 2079121 atttttagat tatcaaaaat ggagaaaatc ccaaaaagag gagtagtgcc tgagcagagg 2079181 cactaactcc tcttttgtca ataaccatcg agacggccca gtatatgaat actgggccgt 2079241 ctcttttttt tgctgttatt aatttttatc ctcgctatgc gcgagctcgt cttgctcagt 2079301 attgctcatt ttttcaattt tttagaaatt tttgggattg ttatgtgaga atttaaatgc 2079361 atatcccatt attatttggt aataataaac aaagaaaggg tgacagcatg atgatcaaac 2079421 aatgtgtgat ttgtctatct cttctcgtct ttggcaccac agccgctcac gcagaagaaa 2079481 caccgcttgt aaccgcccgc cacatgtcca aatgggaaga gattgctgta aaagaagcaa 2079541 aaaaaaggta cccgctcgca caggtactgt tcaaacaaaa agtatgggac cgtaaaagaa 2079601 aagatgaagc agtgaagcaa taccatttaa ctctgaggga agggtcaaaa gaattcggcg 2079661 tttttgtgac gatttcattt gatccttata gccaaaaggt caataaaatt gccatattag 2079721 aagaatatca ataaggtcct ccattttttg aaggacctta ttcgtttatt tgcggttatt 2079781 ttttccgttt cagccaaagt cggaagccat agggtaaaat accgaaccac tgctgggaaa 2079841 caggcgtttt tgtttctttc cgcacctctt ttcgttcttt tcgctcatct ctcggagtat 2079901 ctatatattt gacaaattgc tgcgtcatat atttaacata atcattcgtt ttcacgtgat 2079961 cacctcatca ttcaattatt atgagtgttg tctcacatga ctttttttat accctttaca 2080021 ctgttttatt ctgtccatct cagcagtttt ttctgttttt ggtcaaacac gatctgtgca 2080081 gttctttctg ttcccgaatc cgttgacact cttaagttga tttctttttg ttcttttatc 2080141 gatgtatcat gaatgtaata agaaacccgt ccatatagaa attgctgcgt accctcctgg 2080201 cctttccgtt cctctagaac atgccgaatc gaaagaagca ccccattttg aagcaaattc 2080261 tctcctatgt ataactcttt tgtttccttc tcaaacatgc agcgtgaaat atattgagca 2080321 gcaacaaagt tcacgattaa cagcacaagc gctgacacaa aaagaacagc tggataaata 2080381 aaccctcttg tacgatacat tcacccccct cctaaatacg aatagactgg aaaagcagtt 2080441 tgatacactt tttggtcttc actctcaatt ttcagcaaaa caacaccatt ttcaatatca 2080501 gctttcatgg cagtaatatg atctaaaatc ggaacatgcc ctttgccatc cactcttttt 2080561 cttatcattg aatgataaat gtcaaaacgg atgtcttgtc cggaaagatt ggtgcagatt 2080621 aacacgctcc catgctcggc tgtcttaact gcctgtgatt ccttgcattc attcatcatc 2080681 tgttctatcg aaatcatcca ttcctgctgt gtgaaaccgt catgttcctg ctgtcgagac 2080741 aaaaacagat ggataatcgc agctaacgat cctgatatga gcaaaaagac tgagagcgaa 2080801 aataatacgt taagaagcgt gtagccattc tgtctgcaaa atgctgaggc aaaatgattt 2080861 ttctttataa gctgcggctt tgatacatac gttttgatat tcgccctcct cctcccactt 2080921 cattgcatag atatgattgt tctttgtaat cgtttttgac gcggctcctt caccactcat 2080981 gacatatttg ctaatgctct cattcatcat ctgatagcca atttctcgtg attccgccat 2081041 tttttcatca gccatcagct tgtcccacaa ggggacgact gtcagcagca caaacagcca 2081101 caggcttagc gcagacattg tttctattgt agaaaaacct ttattttctc tccacattga 2081161 ctctcccgct ccctagataa actgttatgt cataaacggc atggcctttt actcgtattt 2081221 ttccgcctgc attcgggtgc cctttctcat taaattccaa acggtctttt aatgtcagca 2081281 gttctataga aagtcccgtt gcatacggac gttcaataac cgtatcacca atgactaatt 2081341 gatattcttt tttatgaaag agaatttttg ttctttgttg acgggaaata gcagtctgct 2081401 gtgtgagcat aatatcattt ttcagctgac ttgctgcctg tcggacagct gtattgtcat 2081461 aagcaggagg aagtgtagtg aagacggcca ccaggaggat agaggcaagg cttaacacaa 2081521 gcaaactttc taaaagggta aaccccttct cctcgtttaa tttaatgttc aaccttaact 2081581 tctccgccgg tgatgataat gcgcttacca tttggacaga cagcatcctt tttcacatag 2081641 ccctctgact gtaaatcggc aaggctcgga gtttgtcctt catgatcaag ctcaaatgca 2081701 gtcatttgtg ccttaaccat gttttgtaag ccttcacagc cctttttttg aatggtttga 2081761 ttatgtttcg tgacgttcgg tatcgtaatt aaaagcaaaa tcgaaataat aaagagcacg 2081821 attaacattt caacaagtgt aaatcctttc tcattcatca gcctcttcct ttcacatttg 2081881 attcatcatc tgatacatag gcacaagcat agataaatac acaagtaaga tcatcgctgc 2081941 aacaaatcca taaatcattg gctgaaggat gcctgtccat ttttgcgctt tgtgttccag 2082001 ccgctgtaat atgaattggc tgtatgtgaa aagctcccga tccaatcggc cgctcagctg 2082061 gccgtgagat atgacttttg ataaatcagt ttcataaaaa aggcttccac aaatagcgga 2082121 ttcaattgac tcaccggctt ttagccgttc aatcaattgt tcagcctcgc agcggtagaa 2082181 agggagaaac gtttgatgtt taaatgcatt aaggctgtca taaattgaga ggcctgattt 2082241 taaaaggctg cttagctgca aagaaaaaaa gtagctgtta aacagcttta caagctttcc 2082301 aaccaaagga atcctgatac aaatcagcat ttgccgggca ggtgattttt tcttaaacac 2082361 aagccaataa taaatcccga tacctgctgt aaaaagaaca agcaaaatga tcacaagatc 2082421 aatatgctga aaaaaagcaa aaagcatatc ggttgaacgt gaggtttcca tattcatcga 2082481 ttgatagata ccggaaaact gaggaatgat gatggactgt aacatataaa acatgacagc 2082541 gaccgtaaag atgaggaaaa gcggatagcg cagcactctt ttcagctggt ctgcctgtgc 2082601 aatttttcgt tccagcagct ctccgctctg gatcattgaa gcaggcagtt caccatgtgt 2082661 ttcagcaaaa taacaaatac ctacggcttc cttatgaaat gacaaactct ttagtacttg 2082721 ataaaacgga gccccttccc tcaaacaagt gaccgaatca gtcaagtcag ccgcctgcct 2082781 cttattcatc tgaagttcca tcaggcgtaa tccatccaga agtgtatatc cgcccgcagt 2082841 catttcaccg agcctcttta ataacctggc ttgatccttt aacaaccaga cttttctaat 2082901 ctttttcatg ataaacccac cggtcatagt tgtttgtcgt taaatagccg agcgcaattc 2082961 cttttctgat aatttgacga agcgtttgat attggtaatt tgcatgattt ccttttgcct 2083021 cctggataca ttgctgaaga tttttcccgt atagaagctc ataaacgcta gctctcctag 2083081 tatttcgtga ctgtcggcaa tacactgatg aacatccgtt ttcacaaaac gggcaagcca 2083141 aatcaaccaa gcgctgagcc gctattgcaa tgacagtctg ttcgatttca ttcatattga 2083201 taccgaattc aagcagtctg taaattgcgc cctttgcgtc tctcgtatga aggctcgtta 2083261 gtaccagatg tcccgtcatc gctgcccgca ccgcaatttc agctgtttcc gcgtctctga 2083321 tctcacctaa aataatcata tcggggtcat ggcgcaaaat tgctttcaga cctgcggaat 2083381 aagttacacc ggctttttca ttcacctgaa cctgaagaac atcttcgtcc cttgtttcaa 2083441 cagggtcctc taatgtgaca atatttcgat taaagtgttt ttttgcatat tgaacgagag 2083501 agtataatgt ggtagtcttc cctgaaccag tcggcccggt aaaaatgagc atgccatggg 2083561 aatgttttaa aaacgagagt aatgtggctc ctgtcttcgg aaatagcgac aatttatcaa 2083621 tcgaagggat attgtattgg ggcatcactc tgatcacgag gctttcttca ttaattgtgg 2083681 gcagcgttga cattcttaaa tgaacatttc cctctttcaa ctttaacgta agcgaaccgt 2083741 tttgcggctt tcgcctttca cctatatcca ttgctgaaag aaatttaaaa tgtgaaatca 2083801 gtcttacgca ctcttctttt ttcatgtccc tttttttcag caaggcatga tcgacccgaa 2083861 aatgaatgat agcgtcccgc tccctcggca caatgtgaat atcagaagcc tttgttagat 2083921 atgcctcttc aatcaagttt ttgcttacct tttctattga atccaatttg attccctctc 2083981 ctttcaacgc atattgtaga aaaagaagaa aaggtaatca aacagggaaa acgtgatttt 2084041 gtgagatgtt atatgctgaa aaaccaattc tttctggcaa gaaaaaagac tttcaactga 2084101 atgtacccct gtcattataa ttttccctat aaataaaaaa gcagacatgg tcaccatgcc 2084161 tgctagattc cattttcatt atgctgtttt cgcttattga ccagtatctt tctcaacgga 2084221 aagatcgcct aatgcaacaa taccggtcat ttggtcattt tcaagaatcg ataaactgcg 2084281 gatttaatgc tctgtcataa gccccttgac atcgtatccg gtcaccctga tatgtctggt 2084341 gaaaaagcgg ggcacgctgc acaaaatatg aaacatccta tagagtccgc ctttttcgag 2084401 gtttcttttt cttcttccgc tcctgcagca tatctcccgt ccagcctttt tttctcaaat 2084461 agagatagat cagaactgta gatgtgacaa tcaataagag ggaaaagaga tatccgtatt 2084521 tccaattcag ttccggcatc actgaaaagt tcatccccca taaggcaccc agagctgtaa 2084581 tcggagtaaa aagcgtcgtg aaaatggtca gcgcttttac aatttcattc cccctatgtg 2084641 aggtaatgac ttcctctgaa tgcagcagat tgttaagctc cccttcaaat tcgctgatgt 2084701 atgtaaatcc cctgtcaatc ttcagttgtg tccgctgata atcctttttc ccttcatttt 2084761 gaggtaaaaa ggtttctttc aacgccattt caattttttt agcgcttaat atcaaatttt 2084821 tccaaatcat cagttcatgg cgcaggagat ggacgcggtt taaaatgctt ttgctattgt 2084881 cgtctttaat ttgccatctg agctttctca gcttgacttc aaattcatca acaccgatta 2084941 aatacgcatt cattagttcg ccgagaagaa ttaaaaaccc ctctatcgca ttgtccgctc 2085001 tttccatttg ccgaacaact tctttgcctt taatctctct caaaattgaa aagtcaaagt 2085061 tgattgtaaa aaaatattgt ctggtgatat aaaagtgaaa aacagtatgg tctttttctt 2085121 caccaagccc ctgatcataa acaatcgacc caaatactgc ttcattttcc gtttcagttg 2085181 tatctactcg caaaaaatta acgtgatggt tattttcaaa ccacttttca cactgaggcc 2085241 agtgagaaaa atggattaga tctcttgcct tacttctttc ttgaggcccc atttggtacc 2085301 aaaaccaatc ctttcccgta tgtgccttca tgtcaagctc ctccaaactt ttgttcttta 2085361 ttctttaatt gcccaataac cgcgtcacta aaccagtctg ccgcttcaac acatgtttta 2085421 tgagcatttt caggtggtat ggaatgtaga aagacatcgg aaaagggagg tgcatgcctt 2085481 ccttggagaa ggcagttgtt ttggaattta tcaatttact agcagtcgct attctcattt 2085541 tgttaacagg atttttcgtt gccgtagaat tttcaatcgt aaaagtgcgg cgatccaaaa 2085601 ttgatcagct tgtcgcaaaa ggaaagaaag gtgctaaagc ggcaaagcat gtcatcactc 2085661 accttgatga atatttatca gcctgtcagc tgggcatcac agtcgcagct ttaggactgg 2085721 gatggcttgg ggaaccgact gtgcaaactc tgcttcgacc gctttttcat aaagcaggct 2085781 taaatgaatc gcttacccac ctgctttcac tcgtcatcgc atttttagtg gttacgtatt 2085841 taaatgtcgt tattggggag ctggcgccaa agagtttcgc cattcaaaaa gcagaaagca 2085901 ttaccttgtt gttcgctaaa ccgcttattt ggttttataa gatcatgttt ccattcattt 2085961 ggctgttgaa ccactctgcc cgattgatta caggagtgtt tgggctgaag ccggcatcag 2086021 agcatgagct ggcttataca gaggaagaac ttcgggtcct attggctgaa agctataaaa 2086081 gcggcgagat cagaaaaagt gaattaaagt acatgaataa tatcttcacc tttgataaac 2086141 gaatggcaaa ggaaattatg gtgccgcgaa atgaaatggt tagtttgtca ctagatgaag 2086201 actccatttc aaatcttcag gaaacagtca agcaaacaaa atatacacgg tacccggttg 2086261 taagagagga taaagataac gtcattggcg tgattaatat gaaagaagtg ctgttttcca 2086321 tgctgacgaa agatttttca atcaagaagc atcaaattga acctttcgta cagcccgtta 2086381 tccatgtaat tgagacgatt cctatttata aactattgct gaaaatgcaa aaggaacgca 2086441 ctcatatggc gatcctcata gatgaatatg gcgggacgtc cggtttggtc actgtcgagg 2086501 atattatcga agaaattgta ggagaaatcc gtgatgaatt tgatgcggat gaagtgcctc 2086561 atatccgcga acttggaaag gatcattact tgttaaatgc aaaattatta atcagcgatg 2086621 ttaacagcct gcttggaacc gatttatcag aggctgaagt agacaccttg ggcggctggt 2086681 ttttgacaca aaacatagac gctgagcctg aaagtgccat agaatatgat ggctactctt 2086741 ttaaggtaaa agacatcaac agccatcaca ttttatttat agaagttaaa aaagctgaat 2086801 agcccgtgaa aggctgttca gctgctatct ttcaagataa acatggcaaa ggcatcaaca 2086861 ctcttttatt ttaaaccctt tattggccag ggctttagca agactttgct ctgttttcac 2086921 attcgaaaaa tccagaccca gcttcacgac agtttgggca atttccggcc tgattcctga 2086981 aataatagtc tcaatgccga gcaatttggt gctgtcaatc actttaaaaa tttgataggc 2087041 taccatggta tcaacgatag gaacgcccga aatatctaaa aataaatacg agagctttaa 2087101 cgctgagcac tgctccagca cagactccaa aatcgtcctc gctctgtgcg tatcaatttc 2087161 accgacaagc ggaagaatcc caattccatc agtaatcggc ataatcggcg cactcaattc 2087221 attaatcatt tctttttgcg cgtttaattg tatcatggtc acctggtgat attcttccgt 2087281 aaacacttcg atgatctcat caatgttttg attcaagatc cggctccact cataaaattc 2087341 ctgaatgctg atgtcttgag aagaagcttc gctgaattta tgaatccatt caaacatgat 2087401 gtgcctgaaa gtgttaaact ggccgacact ttgtgtaacc gtcacttcat gaacggcacg 2087461 gtctctggcg cattgaagag accaccggtt gagctcatcc tctacgtctt cttttctaag 2087521 ggattttgct acgatggtca ccaataattc atgctggtct tttaactttt gttctagttt 2087581 ttgctgatct ttcgctgaat acagccagct gccgtttgac gtacaaactt ccagccattg 2087641 ttgcgtaata tcttttttgt gctctgttaa gtgctgatca agagctatca tcttaatgag 2087701 ttacctcctg tttttgaaaa atgtacgcta tatatgtata acgcgtctgc ctttacacat 2087761 actatgttta gattcaatgg gctatagcca agcggtaagg caatggactt tgactccgtg 2087821 atcgttggtt cgaatccagc tagcccagtt tctgaacagg tgaaaaaccg aagataagct 2087881 gattcgtata aatcagcgga tcttcggttt ttcatcatgc agattgatga accgttttct 2087941 tcttcgataa cttcaacagt tctcccgggt tataaccaat caccagcttt ttgttgtcta 2088001 ctagaatcgg gcgtcgcaaa agcttcggct tctcgattaa aagttccagc acctcattta 2088061 ccgtcatttc ttcaatgttt aaatttaaat ttttgaaagt ctggcttctt gtcgccaaaa 2088121 tttcatcaat tccttctgtc gttaacgata aaatgtactt taattcttct cttgtcgggg 2088181 tttctctgaa taagtgccgt tcgttaaatt caatttgatg tgctttaagc caatgttttg 2088241 tttttcggca tgacgtgcag cttggatatg agtaaaaagt taattgttgt tccattcgtt 2088301 ttttcctcct cagttaacca tctctttgta gaataactac ccggatcatt tttcatttaa 2088361 accatttaca gaactttttt cggattattt tttaaaaaac attcatacaa tagaaaacac 2088421 aatcaaaggg acaaattcca tttgtatatt aataatgaaa atgtttacat ttctaggtgt 2088481 gatctattat aataacagtc agagggactc tcgggagggg ataaaaatga atcgcatgtt 2088541 ccgggtgtta ggattttgga cgggaatttt tgcagtcatg ttttatttag gtgatatgaa 2088601 agatgcttcc cttttatttt ttggacagac gatcttattt gtgtttctat cgtatttgaa 2088661 cttaaccgaa cgcatgtata tttatatttt tggcgcttat ttaacaattt tcttcgccgg 2088721 ctttacatat tactcaattt ttattatggt gcccggcggc ggaggccatt aaatgcagaa 2088781 agagacaaac cttatcggtt tgtctctttt tttacaatga aaacccattt aaaaacggat 2088841 tttgatcctg ctcagtcagt acgtctgttt caggtccatg gccgcttaac accagcgtgt 2088901 gttccggaag cgtaagcagt ttttcatgaa tggacgtcag cagcgtctct tgattgccgc 2088961 ctattaaatc cgtacgtcct ataccgcctt ggaacaagac atctccggaa atgaccaagt 2089021 ctgcatcttt cacgtagtaa gacacactgc ctggtgaatg tcccggcgta aataatgttt 2089081 ccaaatgaaa cggcccgata ttcaactcac cgtcgccttc aattagatga tctgcaggct 2089141 tagctgtgac ttctatccct cgcagcatgc cggagccgtt taaagaagcg tccgcaagcc 2089201 aatttttttc attttgatgc aggtaaacag ggatatccca tttttctctc acttcatcaa 2089261 gcgccccaat atggtcaaaa tgggcatgtg taagcaaaat ggctaaaggc gtcagccctt 2089321 tttcttttat gtattgattg attttatgtc cctcgccgcc cggatcaaaa atcagacatt 2089381 gatcatcact gatgagaaaa tatgcgttcg cttgaatcgg ccctactggc attcgtctcc 2089441 atttcactat tatcacctct ttctttttta tgctcttatt atgagggttt ttgaaaaaag 2089501 attcaaacaa tcgcaatgaa aacgctatcg acaaacctat aaaaaacagg tagaataaaa 2089561 ctggaaagaa ttgcaggttt ttcaatgtaa agggggctgt gttatgttac ttgtcgtgat 2089621 tttcggcctt gtcgctcttt tcgctttatg gggagtcttg cgttctgtta gaaataaaaa 2089681 tatactcggg tttttattag ccggtgccac cttatttgtc tttggatggt ttaccgtgat 2089741 gaccgtaata aacagcgggt atccaaccgc acattaaaac ctgtatccga tcggatacag 2089801 gtttattttt atggctgtaa atgtttattg acactttcta ttttgctctc aagcgtcgtt 2089861 tttttgtcac gcctgtcatc gatacggata ttcgttgcca ctctgtgcaa tcctttttga 2089921 aatggcgctt cgtgaattgc ctgaataact gcaaaaaggt cactgagttc tccctcgatc 2089981 agcgtattca tcggtgtcag ctgatatttg attttccctt ctgcttgata tccttctaat 2090041 atcttttgca catcggctac gtaagcactg acactgggtg tttccgtacc gattgggata 2090101 atggttacat ctgcgatagc catcgttatt ccatctcctt ttgatcaatg atgagttgct 2090161 tcgtttcatg tgatttcaat aaaataattt gctcaaaatg aaagccgtat aacgcatatt 2090221 tcccgttcgg agatatttga atcggctcca tttcccgcag agacacaaga tcttttgtct 2090281 ctcccgatgc tacattgatt gctgcgagct tatatgcatc gccgctttgt ttgaatgtat 2090341 aaaacaggcc tcctgcttca tcatagtcat actccattgg agccaaactt gtatatttcg 2090401 cttggagcgg ccatttcgct gtaacaggtg atgttgattg cggcgtttta aactgatacg 2090461 tcccttttcc tccggaagct gatttgacag taaaactcat ttgatggaaa gaatcgaaga 2090521 atagaacgtt atcctcaagc ttctgttccg tcttagaagc tgtatcgaac gtatataaag 2090581 gccctgtttt atcgtctcta ccctctttta cataatcaaa tgtatttttg gatgtccaat 2090641 gaatgaacgg aacctgtact gggcttaaga aagattcgtc ttttttagca ttcacctgat 2090701 atgtatggaa atcccagttt tcattgaatt ccgtcaccat catttgataa ggatcatact 2090761 gattccaagc agcttcaagc tcatacgttt cgtaatcttt ttcgtaaagc gtctctcctt 2090821 ctgcattaag caaaaccact gccgtctttt ggctatgtgt gatttgcagc agaatcatct 2090881 gctccctcgc attgatttga acatcaacga tttgaccatc cgtttgatag agctttttcg 2090941 ctttgcctgt aaagatgcgg tacgcaaaaa gctctgtttt cgtcggatta gacgcagtat 2091001 ataatattgt gctgttattc agccagcctt ccgccccatc cgctttttcc gcggaaagcg 2091061 gtatgatgtc ttttttctca tcttttgccg ccgatgcctg tttttgctgc tgatgagatg 2091121 gttcgcatgc cgataaacta aacagcaata ccgccagcag aataaaacaa actgatctca 2091181 tcagcattcc cctccgatca tctttattct ctcatatttg cttcggcaga aaaaagaaaa 2091241 agtttcagtt actcatgaaa aaataacgcc ctccacaaga taccgcttgt ggcgttatat 2091301 atgtgtgaaa actgctgaaa cggcaaagga ttttggcctt ttccaagttc caccgtatac 2091361 ccttccttaa aataatggtg aataaaccaa tcacgaaatc cagcatagct gtctatatcc 2091421 cttactccct tataaatgtt cccgcttaac tcctcaaact cctttatgac ggcagcagat 2091481 tcctcaggct caaggccttt atagccccaa taaatttctt ctccttgagt atgaagagcc 2091541 agcagtctgt caggcggatt ctccgtgatc agccggtaca tcgcaataga ttccggctcc 2091601 gtaagcggag agattcccgg aaaatcgcgg tagctgggtg ctgtcggttt tcggtatttt 2091661 tcaatttccc ataatgatgg aaattgttta tttaaatcaa ccccgtttat attcgccttc 2091721 cattcattaa aatttggacg atgttcattt agcctttcga gttcatctct tctggctccc 2091781 atgacttctg atccgtttaa aacaagatca acgccatccg gattgacaag aggaacgagg 2091841 gataaggatg tgctgttaaa cagctttatg ggagaaaagc caaagaaagg cgaattgcag 2091901 cataatgaca tacagtattc cttaaaccat tttagcagga cagacgttgt aatccactca 2091961 ttcgcatgaa atgacgcgtt catatggacc ttttttacgg catgctcccc accagccttc 2092021 agctcccaga taggcctgcc gagtacagaa cggccaattt cccggcatga gacaaacgga 2092081 aaaacatcaa taatcttctt tatttccttt tcaacagctg aatcatcata gattttctct 2092141 tgctcaatcc agctatctga aagtttcagc tgccgaggct gtaaaaagcg ctttatgtcc 2092201 tgaatggttt gaagctcttt gccgctatgc tcctctatca cataaccagg gcaatacaat 2092261 tgatgttttt gtgcggagcg atttgcactt ttaagcaatt cctcgtctat cttcagttct 2092321 ttcgccacat tggccaaatt gttcttgatc tcaggtttca ccgtaataaa cgccatcatc 2092381 atcccccttt tttgttacta tatgacagcg tatttaaaaa aagaaagcct cccgctcact 2092441 tcgatgcggg agacattgtg attatgatgc ctgatcaagc atttgttttt ctttccgctt 2092501 tgacgaattg tccagccttt tctggtcata aaatcgcaac aaatccccat aaatgatttc 2092561 atcagaaagt gatagctcct gttttgcttt atcagcaaat gcttcacatt gttttgtctc 2092621 ttctaacggt tttcccgtct ctttgtcata acacgcaccg tctgtataaa caacctgatc 2092681 tgtgataaag ctcccgtccc ggagcaccgt gaagtccagt ttttcgtctg aaagcagatc 2092741 gttgccgaat tgaatttgat ctttcgtatc aatccctaaa agattcatca gcgtcggcct 2092801 gatatcaatc tgcccgccta ctgtttcaat ggtttgcggc tttttatcag taatacccgg 2092861 aatatgaatg accagcggca ctttttggag ctgtacctct tcaaatgggg ttatttcttt 2092921 tcctaaaaac tgccccatcg cttcattatg gttttctgat ataccataat ggtcaccata 2092981 taatacaata acagagttgt cgtataaccc gtcttccttc agcttttcga taaaccgttt 2093041 cagcgcctca tcctgataac gcactgtcgg aaaatattta tttagcgtct ggctgtttga 2093101 atcatattca tcaatcaatt gatcctcttc atcaagatca aacgggaagt ggttcgtcag 2093161 tgtaatcagc ctcgagtaaa acggctgagg cagatttttc atcagctctg aggactgctc 2093221 aaaaaattct ttatccttaa gtccccagcc gactgaattt tcgtcagtta catcatacga 2093281 gttaatatca aaaaacgaat catatccaaa tgagtcgtac attaaatcac gattccaaaa 2093341 gctcttatta ttagcgtgga gcaccgctga atagtatccg ctgtttttca aaatttcagg 2093401 agcggccata tattgattgc ccgcattcgt aaaaaatacg gcacctcgtc caagcggata 2093461 cagtgaattg tccacgataa attcagaatc cgaggttttc ccctggcctg tttggtggta 2093521 aacattatta aagttgtagc tctgttttat aaagtcattc agaaaaggcg tgatttcttc 2093581 tccattcaat ttttcattaa tcacgaagct ttgcgtcgac tctaaggata cgagaatgac 2093641 gttccttcct tttgcagcgc cgaataagcg tttgttggca tccttcgcat tagcggttac 2093701 gtagttttca atctccgtca ggctgttgct gtctgccaac gctctctgtg cggattgctt 2093761 tgactgaaga acgccatcgt aaatatgaaa attaaacagg ctaatgtttt taacaagcat 2093821 ttctctgtca aatgagcgtg tcaatagctg aggtctttcc gcctcagaca agcccaggtt 2093881 gaagaaataa acagaagcaa cgaacaaaaa ataagccgcc cgttcatttt tcgttgaggg 2093941 aatgtccgat tgaaaagctt tttgccggat gtgaagccat attaaaaccg caatatctac 2094001 agctaatagg aggtctgtcg gctcaagaag tgttccgatg ctgcttccga gatcacccat 2094061 attgctcgtt tgaaaaagaa cagggattgt taagaaatca ttgtaaaaac ggtaaaaaac 2094121 catatttgcc agcaatacaa acgtgacaag acagctcatc gcgataatgt agcgatttct 2094181 gtttttgcct tttaaaaaca ggctgaggcc aaaaataagc aacaaaaaac tcaatgggtt 2094241 gataaacaga ataaattcct gtgttagatt gtcgatttta atatgaaaac tggttttgta 2094301 aacagcatac gttttcagcc acatcaataa aatggcaatc agcataaatg aaatcttcga 2094361 aaaaaacgtt tttcgcattt caacctccta tgcagcacgc tcaaaaaaat cagtctattc 2094421 ccaacattct cattaacaca tcaaattaaa tcttaacctg agcacaacaa aaaatcaatt 2094481 tcatttacac aattttaaca attttgatgt ttcagccatt catttttagc gatccaagcg 2094541 cctccgataa cgccggcatc atttccaagt gctgcgattg aaatatcagc agcttgggct 2094601 gcccgcggaa acgcgcattt gcggaatgtt ttctcgactt ttgatctcag cagttctccg 2094661 gctctcgata cgccgccgcc aagaacgatt ttggatggat taagcgagct tgccaaattt 2094721 ccgagcacca aaccaagatg cttggctaca taatcaacca cctcaagggc aatttcatca 2094781 ttttcacccg ccgcttcaaa cacatctcgc gctgacaatt gttcggttgc ttttaaacgt 2094841 gtcgtctttt tagcatttgc tattttttct tttgcaattc ttacaattcc ggttgctgac 2094901 gcaattgttt cgatacagcc cgttttgccg cagttgcagg gcgctccgcc ttcagggatg 2094961 ctgcaaatat ggccgatttc tccgccggcg ccatttatac catgtacaat ttcaccattt 2095021 gcaatgatgc cgccgccaac tcctgtgcca agcgtcacga gaatgacgtc ttttgcgcca 2095081 tcacccgctc ccttccacat ttccccgagc gcagcaatat tcgcgtcatt ttctataaca 2095141 gctgggatgc cggtttctgt ctccagatgg tttttcaaag cataattttt ccaccctaga 2095201 tttactgttt cataaaccac tcctgccgcc atatctacag ggcctggtgc acccattccg 2095261 atgtatttga tgatgtgctt cggtttttgc agctcatcca gcttgctgtc gattgttttt 2095321 gcaattgtga cagtaatcgt gtcgccggtt ttatctgtcg gaacttccca cttatgctga 2095381 atttcgccat attgattaat aaaagcgagt ttaatcgtcg ttcctcccag gtcaatgccc 2095441 gcaaaccata tctcgtccat ttttatcacc ttagccttta taaaaatctc ttccgttttt 2095501 tgtttgttcc aattcttttc gaaggacagc tgccgctctg gcccactgct ccttttcaat 2095561 catgtggttc atgtataatt cctttaattc atccagcata aactcaattt caagctctct 2095621 gtctccaaaa taaacaatgt ggccaaacgt ttttaacagc tgctgcacat cataaaatgt 2095681 attcattttc ctcaccattt cttgaactta actatcataa gcgtattcat aaggaagcgg 2095741 tcagtcaaga agaaaacgct gacaaaaaag ccagcttcct ttccatattc cacctctatg 2095801 attctttatt gttttcaatt tgccgctgca gctccttgta gcgctgctcc ttcggcttca 2095861 gtttcacagc cgtctggatg gccttttctg cttgtgcaag ctcatttttt tccgcataca 2095921 ataacgctaa attgtaatag gaagcatggt ctttaggttc ttttttcact gctcgttcca 2095981 aaagggaaac cgcctgatca tattcgccga tttgaatatc agaaacagca agaattttca 2096041 aaagatcggc agaggcatct ttttgcgctg cttctccgtt cagcaattct gttacttctt 2096101 catactttcc ttcctgatac agctcgcttg cctgctgaat cagcgctgac tcctggtgtg 2096161 aaggcgaatg caatccgtaa tataaaaatc caacagccaa agcaatcagc aaaaccgctg 2096221 acaacaatct ttttccaaag gctccggctt taggcaaccc cagtgctgct gcagcgaaaa 2096281 agccgccaat caagccgccg atatgtcctg aattatcaat attcgaaacc gcaaaaccaa 2096341 agcccagatt gatgataata atgacaataa tattggttcc tatagttctt aaaaacattt 2096401 ttcgattaga caaagcaaca tacagtaatg cacctaagca tccgaatatg gctcctgatg 2096461 cccctgccga aggatacggg ctgaacacaa aactcgcaat cgaacccgta atgccagcag 2096521 ccagataaat cagcaaaaat ctccccgatc catacatccg ctcaaccgct gtaccaaccg 2096581 accataaagc cagcgtatta aaagctaaat gcgctatgcc gatgtgaagc acgatcggtg 2096641 tcagaagccg ccaccattct ccttgtgcaa tcaggctgtt ttcttttgct ccaaaagcca 2096701 ccagtgtctc cgtattagtg ctgcctccgt ttatttcgag caagaaaaac atcaggatct 2096761 gaagcgcaat aaataaatat gtaaaagtcg gttttccgtt ttgaaaaacc gccgcttcag 2096821 tttttctctg ttcttcttgt ttcagcacta gcgaaaggaa gcgttctcgc gccatttgcg 2096881 cgttttcaaa cgaagcgtgt tcctctgaac aatcttctgt acgaaatgat ggaaaaaccg 2096941 cttgaagatc atctcgaagc atcgttcctc taacgatcgc cggctcaact gacacagttc 2097001 ccttctcaaa agtttttttt gcaatctctt cccagtcatc aactggggct tccgttgaaa 2097061 aaaacacgtt cagcagcttc atccttcgtc tgcccaattg atgtctgact cgttctactc 2097121 gttcggcctg ctcttcgatg tctctaacca tttcttgacg gaaatcaaga tcgtgcttat 2097181 aaagacgaac tagatcatga gaggacttgt ccggcgcttc cagccatatt tcatctgact 2097241 caccggcttg tatgacgcca tacccgctat tcaccaggtg cgccgcaatt ttccaatatg 2097301 tatactccag caaaaacatg tttaccgctc caatagtttt ttttcattat aacagctggc 2097361 gctccgaaac gcctactgaa agcaaaaaat cccgtttttc acgggatttt agaaagcttg 2097421 ctgtataaac ttattgcgga taaatggaat tcttaaaaac aaatggataa aagaccgcct 2097481 gattcctggc tggctgagta cagtattcat aagacggtag cgattttgat aaaacatgac 2097541 ggcagaaacc gcgaaaatgg catatatcaa aagttttttc atgatatccc tcctgccaat 2097601 agggtttgtt attctacctt atttattctc gaataaggga caggaaagtt atgaaaaaca 2097661 agaaataatc cgatcctctg ttatcagctt atgtaccggg atgtcatgcg gcagacgggg 2097721 tacgtgcgca aacaactggc actccaaaag caaagagact gtcttccctt catattcact 2097781 taaatagcga tcataatagc cgcctccaaa gccgacccta aacccgttaa catcaaaaca 2097841 aacacccgga acgatcatca agtcaatttg tgatgggttt acttcttttg ttttttcaat 2097901 taccggctcg agcagtccgg cgtacacggt ttcgagctga tcatcagtct gatatgtgcg 2097961 aaattgcatt ttcttcgtgt ccggatggca ttttgggatg caaacttgtt tcccttcttc 2098021 ccaagcctgc tcaatgacag gacgcgtcgg tatctctaat cctctggaaa tagtgacggc 2098081 aatggtgccg gcattttgcc actccggcag agaaaacaag tacttataca tacgttccgt 2098141 tttttgaaga atatcttcat ttgataaagc agacagtgcc tccagcgtct tttttcttaa 2098201 ttgtgatttc atctctcatc cccctcggaa tagaaaaaaa gccagaacct ttttcaaagc 2098261 tctggctttt ttcttacacc tcaaacagca aagctgttat tttgtttcac ggtgtaacgt 2098321 agatttttta tcacgtgggc aatatttttt aaattcaacg cggtctggat tgttgcgttt 2098381 gttcttttta gaaatatagt tacgctcacc acattcagtg caagccaaag taatattaac 2098441 gcgcattatt ttccctccaa actaaaatca tttacttatt cagacttata tataatacca 2098501 ctataatgga cggaatgcta ggctgttttt caatgaattg ctgaattatt gaagatacgc 2098561 tcataaagct gcaaatatga tgacataatg agtcgggggt ggtggagctt gaacacttgt 2098621 tgtctgccag cttcttttat ccggcgggct ttttcccggt cttttaaaaa actgtccagc 2098681 agatcagcag cttcctgtac gagcgtaaaa tcagcgatga ttgccgtttt gtcatgaacc 2098741 gcataatcac aaaaaccacc tgactgagaa acgacagtca gcacaccttg ttccatgctt 2098801 tcttgcgcgg caagcccaaa cggttcataa gaactaggga aaacagccat ttcacagtga 2098861 gacagtaacg ttctgatatc tttcctattt agaaacggca gaaacatgac gcgatccttc 2098921 aggttatatg ccgcagccaa tttctcatag caggacagag acggcccctc cccagccagc 2098981 actagataga ggtcaggctg acgctgcttc aagatggcaa acacctttaa cagctgcgat 2099041 aatccttttt ccggaacaaa ccttccatat gaaaagagga atcttctatt catgcttctc 2099101 gggattttcc ccttctcttc ctccatagat gcagggcttg ggataacggt tattttctta 2099161 tgtgccgcct tatcaagaga ccgcttcata aatgtgctta atacgatcaa tgcatcagcg 2099221 gattctataa ggagccgttc ggtcatgagc ctgtatgggt gtggggcttc tcggcacacc 2099281 ttcttccttt cgctttcaag accgtggatt gtcgcagcaa gcggaaggcc aagccgttgt 2099341 ttcaaatact gggcggcagg ggcagttgtg tcatcatggg catgaatcag atcaaagcgt 2099401 ttattgtgtg ataacacatg gcgaaccatt gtaaagttag catcagctat gtaatcttca 2099461 aacttcgcat acgaaaacag ctgcccgctc ggagtaaaaa ccgtaatgtt gatatgaggg 2099521 tttaaatagg aaatgaggcg gtttaaatgg acaccgagcc cgcttttcgg ctcatcggga 2099581 tgttcgggtg aaagcatgag aatgttcacc gttctttttc ccctctccca taacaggtgt 2099641 atgcagaaaa ttgcgcctcc cacctggtgt gcgcttcttc aatctgaaaa ctgtttatat 2099701 gacgaatccc attttcatca agatagatgt cgtctgtacc ggcaagcttg agagagacat 2099761 tcattgaatt cacaattctg tattcagccc gatatacagc atcaccagcc gcctgtctaa 2099821 tcgtccattc tcctttatca tacgttgtgc gttttgtcct gacagcttca atgtcttttc 2099881 ttttgatgac aatgcgcaat tcttttatca tatcctgcgt tttttcgaaa aggaccgctt 2099941 cagccagccg cattgtttct tctgagattt cccagcttac ggtcaaggtg tgagcgtttt 2100001 gaatgattat gtcgaatgtg tccctaaaaa aggaaagctt atgtcgtata ttatagggaa 2100061 atgggtgttt atccatggac tcctaacatt ctcctttcca atcgttcact tcgtgttcct 2100121 attaaaccat tacatgaaga agaagcgaag aaagatttct cgacaaaatc tcgttttttt 2100181 cgcgaattcc tttagaaact attggtttta tggtataaaa aagaaggata aaaaaagaat 2100241 agaaggtgat gaaacgtgga aattgctatt attgcgttgt ttatcgtcag tatagcgcta 2100301 attgcattct catattctca aagagacccg atgaaagatg tagaacagga gctcgaaaca 2100361 ctgcagcttt ctgcgatgca ggaaatttac aagctcaaaa agaaaatgac agtgcttgag 2100421 gaagaattac tggaaacaaa ccttgtcatt cgcaaatcaa agcagaacga catcaatcaa 2100481 aaaatcgcta aacaaatact ttctaaatat aataacggta tgtcagctga agcgattgct 2100541 aaagctgaac atgtatcagt ggaagacgtg aatacgatta tcaaagataa tgagaaggtg 2100601 ctcgtatgac aaaacggggc attcaggcat ttgctggcgg catcatttta gcgacagccg 2100661 ttcttgcagc tgttttttat ctgactgacg aagaccaggc cgctgctgta aaagataata 2100721 aaacagtaac cgaacaagac gtgaacaatt atcttgattc taaaaaattg gtttctgtca 2100781 accgtgatga atatcaaaaa cttctcgatt caaaagagaa atccttaaac aatgacagcg 2100841 gctcagacac gaaatcagac aaagtcaaaa cctacaagct caccattaaa gacggcatga 2100901 gcacggcgga tgtatctgct attcttgaaa aagagggcat tatctcttcg gctcaagact 2100961 ttaatgacta tgtcattgat gccggctatc acaaagaaat tcgtgccggc gagtttaaag 2101021 taaaatcaga catgagtttc aaaaagatcg taaaaacgtt aacacgataa aaaaacaggc 2101081 tgactcagcc tgtttttttc atccaaactt tcctgaaatg taatcgagcg ttctttggtc 2101141 cttcgggtta gagaacattt tattcgtatt gtcgcattca acaagctcgc ccatgtagaa 2101201 aaaggcggtt tgatcagaaa cccttgctgc ctgctgcatg ttatgcgtga caatgacaat 2101261 tgtatattta tctttcagct ctagaatgag ttcttcaatt tttctcgttg agattggatc 2101321 tagtgcagat gtcggttcat ccatcagcaa aatatcagga ttggtcgcaa gtgctctggc 2101381 gatgcaaaga cgctgctgct ggccccctga cagcgaaaga gcggacgtat gcaatcgatc 2101441 cttcacctca tcccataacg ccacgtcttt taatgacttt tccacaattt cctgaagctt 2101501 cttcttattt ttggtgccgt ggactctcgg tccgtaagcc acattatcaa aaatagattg 2101561 cggaaacgga ttcccttttt ggaataccat gccgatattt tttcgcaaat ccacgatgtc 2101621 cactttatcc tttaaaatgt tgctgccatt atagttcagc tcacctgcaa gctttacatt 2101681 cggcgtcatt tgaatcatta aattcaatgt cttgataaag gtcgatttcc cgcatccgga 2101741 tggtccgata atcgccgtaa cctcattttc ataaatgctc aaattgatat tttttaaagc 2101801 atgatgctgc ccataccata agttcattcc attgacttga tatacttcct gtttcattac 2101861 agcttcggta gcaatactca ttgccgccct cctatccgaa tttcccgtta atataatcct 2101921 ctgtcttttg ctttttcgga ctcgtgaaaa tctgttcggt ctgtccgtat tctacaagct 2101981 cgccgtttaa aaagaatgcc gtccggtcag aaacccgcag agcctgctgc atattgtgcg 2102041 tgacaataat aattgagtat tctcttttca atcctgtaat taattcctct atttttgcat 2102101 ttgaaatcgg atcaagcgct gaagctggtt catcaagcag aagaacagcc ggcttcatcg 2102161 caagcgttct cgcgatgcat aaacgctgct gctggccgcc ggataacgag agtgcggatg 2102221 aatgtaaacg atccttcacc tcatcccaga gcgctgcttt tgttaaactt tcttccacaa 2102281 tttcatctaa aacagcttta ttccgctctc cggcatattt caatgcatgt gtgatattcg 2102341 catagatcga tttcggaaat ggatttggtt tttggaaaac cattccgatt tctcttctca 2102401 agctgacaac gttaatattg ccgcccaata tatttaatcc ctcataaagg atttcacctt 2102461 ccgctcttgc agatggaatt aaatcgttca ttcggttaat atttctcaaa aaagtagatt 2102521 ttccgcatcc cgacggccca attaaagcag tcaccgcatt tttttcaata tccatgttta 2102581 catgatgaac ggcttgttta tttccgtaat aaatggacag atctttgacc tcaagcacgt 2102641 ggttctgctt cggaacaata acagctcgct caggtttttc ttttaccatt tgttcagaca 2102701 tgtttttcgc ctctttccgt tctaatttgc cgtaagcttt ttgtagatca tcgtgccaag 2102761 ccatctcgcc gcgagattaa acacaagaac agaaatcacc agcacggcag aaccaccgtt 2102821 ggcaatcgct tcagcatccg gaatcattcc ttgtgtattg acgttccaaa tgtggaccgc 2102881 aagtgtttca gcgggcctga aaatattaag cggtgatgtt tccgaaaacg ggttccactc 2102941 cgtaaaatta agacgcggtg ttgtcaggcc tgccgtaaat aataatgcgg ccgcttcccc 2103001 gaacaccctt cctgacgcta aaattgctcc tgtgatgata gaaggaatcg cacttggaat 2103061 taaaactgtt tttacggtat gccagcgtga tacacctaaa gcgagagagg cttccttcag 2103121 atctttaggg actgaacgga tcgcgtcttc tgtcacacgc accatgacag gaaggttaaa 2103181 aacagttaac gcaagcgctc cgcctatgat cgtataaccc cagcctgtta agttgacaaa 2103241 catcaataat ccaaacatcc caatgacaat agacggaaga gatgaaagca cctctataca 2103301 tgttctaatg aagtcagtta ctttgttatt aggcgcgtat tcagccatga agactccgcc 2103361 gcccacaccg agcgggattg taatcagcat tgtaataaac aaaatataaa aggagttaaa 2103421 cagctgatct cgtatgcctc ctccagctgc aatggcgctc gactttgttg taataaattg 2103481 aaaactgagc tgagaaacac cgtttataat aatataggaa aacaaaccta ctaaaatggc 2103541 agcgataatg gctgcacaca aaccaaacat tccggtcgcc agtttatctg ttattttgcg 2103601 gttcattaca ctttcctcct agatgacaag tagcgaataa gcaggatgaa caagaatgac 2103661 atcaccagaa gcacaagccc cattgaccac agcgtattgt tttcaacact tccgtatgtg 2103721 gtgtggccca tattcagcgt gatgatcgtt gtcagcgttc ccgcagtgtc aaacgggctt 2103781 tccggcaata ctcttgtatt tccaatgacc atctgaacag ccaaagcttc accgaacgcc 2103841 cgagccatgc ctaacacaac agctgtcatc aatgttggaa aagctgcagg cacaagtact 2103901 tttctgatcg tctgccatct tgtggcacca agcgcgtaag aaccctctcg taaactcttc 2103961 ggaagagaag ccattgcatc agcagaaatc gatgtgatcg tcggcagaat catgacggaa 2104021 aggacaatcg ttcccgccaa taaactgtgc cctgttccgc tcgatttgaa ctgggcgata 2104081 aacggcacca atactgtaag acctatgaat ccataaacaa cagatggaat accgactaaa 2104141 agctcaatca ccggctgcag cactttcttt ccccaattcg gggcaatctc tgtcataaaa 2104201 atcgcacctg caatgccaag cggcgcagcg attagagcag aaagaatcgt tactgcaaat 2104261 gagccaaaaa taaatggcag cactccgtat ttcggatcac tatctgtagg attccaattt 2104321 aagctcgtta agaattcaat tgggcttaca ccatttacaa gaaaagattg cagcccctta 2104381 acgccgagga aaatggtaat cgcaacagat gccgcaatca taatcagtgc acaagctgtg 2104441 actatcattc ttccccgaac ttcatccaat tgccgatttt gcctagagct gattaagcgc 2104501 tcgctcacag acatattttc tctattgttt atcattgttt tacactccta tgaatgtgtt 2104561 aagaggagaa acggttgtcc ccgcactcct ctttttatta agatcagctt tgcttcccgt 2104621 tggcatcacg tgtcactttc atatcagtaa ccggaatgta gccttggtca gtaacaatgc 2104681 ttttttgaat gtcttcactc tttagataat caagaaattc tttagctaaa cctgtcgctt 2104741 caccttttgt ataagaatgt tgataagccc agatcggata ctcgccagtt gctacatttt 2104801 tcgcttcagg tttaacaccg tcaatagata gagcagttac tttgtcatct gttaaatatg 2104861 agaatgcaag atatccaatc gctcccggag tatcagcaat gatctttttc accgtgttgg 2104921 aggaatcttc agtaatgcct tctgcaggct ccgctccgtc aagcgcatat ttcacaaatg 2104981 tagcacgtgt gccggaagaa tcagggcggt ttacaagtgt aatcttttgg tctttgccgc 2105041 cgagctcttt ccagtttttg attttgccag tgaagatttt tttcaattca tcttttgaaa 2105101 tatcctttac accagcatca gggtttacag ctgctgccat accaactaca gcgacttgat 2105161 gatcgacaag cgcttttgca tcgatgcctt ctttttcttc agcaaaaacg tctgaattcc 2105221 cgatctgaac agctccttca gagacttgag aaagccctgt tccagaaccg ccagcttgta 2105281 cctgtatatc agcatcaggg ttttcttcca taaatttttc cgcggctgca agtactagtg 2105341 gctgcattgc cgatgaacca gaaatggtta aagaacctga tgccttttct tctccttttg 2105401 cagaatcgct attcgatttt ttactttctc ctgcatttcc gcatgcagct gcaatcatca 2105461 taaaagcagc catcagaagc ataagcacca atttgttttt tttcatttcc tgaattcccc 2105521 ctgcgtataa tgtgtaattt gtcctacacg tatagagtaa aggttctatg taaaaagggt 2105581 ttgaaccgaa tgttaaggtt ttgtaaatca gtgcgttttt ttgtataaaa aaaacgccca 2105641 catcatgtga gcgttttttt ttagttatca gaagacgttg tgttttctgc attttcttca 2105701 attttgtctt tattcttttg ctgagtacct tctttgtcct gcttcgattt cagctcaaaa 2105761 tatttatcca ttacttccct gccgatttcg tttgtaattg agtatctttg attgtaatca 2105821 atgtaagtcc aaggaactac gacagaaata gcaatctcag gattgtcagc tggtgcataa 2105881 gccacaagcg tcgtattata agtgtctgtt cctgtttttg atttatccgg tccgtcgtaa 2105941 aatgattggg ctgttcctgt ttttgcagct ggtttatacg atgctgaagc cagttgacct 2106001 gcagctgtcc ctttagtggc aacccgtcta aaaccggctt ggacctcttc aatatagcta 2106061 ctcttcatat cgactttatt caatacttca ggctgaacag aatcaacgac tgcgccgatc 2106121 ccttttttcg catttgaatc tctgacttcc tttacaagct gaggcttcat gcggtagcca 2106181 ccatttgcta tggtggagac atattgagcc aattccagcg gtgtataagt atcatactgt 2106241 ccaatggcga aatcaagcaa gaaaccagat aatctgcttg tacctttata tcccgtcatt 2106301 tcatttggta gatcaattcc tgtttttact cctaatccaa attgactgaa ataatttctg 2106361 aaggtatcaa atgcagaagt atccaaaggc aatgcttggt gaggtttata ttcaccttta 2106421 ccaactgcaa ttgctgtttt aaacataaaa acgtttgatg acttctctaa tgcagtttga 2106481 ataccaaccg gccctaagtt ttgccaagat tttttccctc ttttatcctg gccgatatac 2106541 aatggttcat ccttaaatac agtattcaaa ttaatcgctc cagtttgaag accggtcaaa 2106601 acggttgcac cttttacagc tgatcccata gcgtaggatg aagtcatggc tcctaatgca 2106661 taatcatcaa acttataggc tccattttct cgtttaatct gcttccctgc cattgtcagc 2106721 acttcgccgt ttctagggtc catcatgaca acgaatgcac gatccaacaa ttcggtacta 2106781 ggtcttgctt tagcagcttt aagttttttc tcaataattt tttccactga tttttgcaaa 2106841 tcaatatcaa ttgttagtac aagatctttc ccggctttgc cttcagatac cgtttttgtt 2106901 cccgtgacat tgccttttga atctgtgata ttttcgactt ttgctttttg gccctgcaga 2106961 aggctttcat attggtattc cagatagctt tttccgaccc tgtcatttcg gctgtagcca 2107021 agcgacagat aatggtcgag caagttggac ggcaatcctt cattagagct ggaaacactt 2107081 ccgagcactg agcgaagaag gtttttataa ggatattcac gttcccaatc ggacgtgaca 2107141 tcaacacctg gcagttcgtc taaatgttca cttaccactg ccatttcctt cgctgataca 2107201 tcttcgtttt tgatatattg aggggtcaat gcatagcccg aatccatctg tcttttgata 2107261 gcaaggatct gcatatcttt atccgtcaat tcattcagct gcttatcagt aatccgtttt 2107321 agctgaagct ggtataaatc gtcatcggat atttttttgt cttcaacctg ctgtctttct 2107381 ttagagctaa tgagcttttt cgcttctttc ggtctagtca aaatccaata atctttttta 2107441 tcccgttctg ttactttttt tgtatcgact ttgatcatgt cagacagctt ttttgcgatc 2107501 tttaagcgct gttcttgcgt ggtcgattta gatctcgtgt atgtgattgc atttaaagcc 2107561 ttatttgtca caatggcatt aaagtttcga tcataaattt tcccgcgtgg taccgctgag 2107621 ctgacttcac tttgttcctg cttattcgct tggtttttgt aatcatcacc ttgcacgatc 2107681 tgcttgatgc ccagttccac aataatccag gtaaatataa caaaggcagc taaaaataaa 2107741 atattcagcc ggatcggaag cgacttcttt ttctctttat gattttgctt ttttggttta 2107801 tttctcctca taacatcacc ttttctattt acagaaagaa aagacactca agtaagagtg 2107861 ccagttttca ttttaaaggt tttttcgact tttttctaca gataacccct ttttggcaaa 2107921 aaaattatct ctcgcctttt aaaagggtcg gttctgttac ccgtttttgg ccgtcttctt 2107981 ccatggtttc attttcccct tctttctcct taaaacgaat atccttgaca aagtaataaa 2108041 tcaaaggatg tcctataccc aatatcgcaa gtgacaaagg aattcccaca tcctctttca 2108101 gaagggccac aatcaggaga aagcacaaaa tggaaacaat tctgccggcg ttcaagaaca 2108161 tttctctaag cacgatatat tcaattcttg cttttctggc atgcctcgcg cgccctatca 2108221 catcatatgt aagtgataca tatggcacaa gcaacagagg atagccgatg gcaataaaaa 2108281 cgccgtacgt taataatgtc gaaaagctca tatggaacag aatcaaaaac agcgcgccat 2108341 acaaaataag tccgcccagc aaaatcgatt tttttctcgc ctttttctta atcagcctgg 2108401 atgcaaagta gtaggcaaag aaggaaacag ctgaattgac aagaccgaat gtaccgagag 2108461 caagctcgct gtttgtctca ataaatacaa acacactgat taaaaagaca aaaatccctt 2108521 ctctcaaacc ctgaaaaaaa tgcgcattcg tgattctccg ccaattcata ttgctatggc 2108581 gctctccaaa tactttgctc agcataaaac ggccctttga ttctctccgt tttaagaaaa 2108641 agctcatcac gacagccagg gcaaataaac tgagggagag actgaaaatc actgtataac 2108701 ccgtattatt ttcaagcctt gagatcacga atccggctac aatcgggccg atcattcctg 2108761 cagaggaaga cagaatgccc ataaacccgt tgaaaaagtc tcgtgtatcc ggctctgtta 2108821 tttcaaaggt cagcacgtta aacgctagcc aataaaagcc atagccaact ccgagcaccg 2108881 cgccgattag cacgaggcgg ctggccgccg tttctccggc taaaagcaca cttaaataaa 2108941 aggcagctaa aaaaatgacg ccgaacctta aaatgaatac cctgtctatt tttttggcta 2109001 accgtccagc caaataaaag gttatcggct gcattgtcac aatggataaa ttatatatcg 2109061 ccaaatcaat aaatttccct gactgcttcc aaagatacac attaacaaat gtattggaca 2109121 gtgcaattcc cagcgagtaa agcccgccaa tggtcagcag aaagagtaag cctttgttta 2109181 cgtctacatc gcctatcact ttttttagtt tgctcattac tgactcccct ttactatccc 2109241 ttagtctgtc tcactcaaac cgagatatgt aaaaagaaga cataaaaaaa caaggtccca 2109301 taatgaggac cttgtttgtg ccattatttt gcttcgctgt atagacgagc cacttcgtcc 2109361 cagtttacaa cattccagaa agctgaaatg taatcaggac ggcggttttg atagttaagg 2109421 tagtaagcat gctcccaaac gtcaagacct aagataggcg ttttgccttc tgaaagcgga 2109481 gaatcttggt ttggcgtgct tgtgatttca agtttaccgt tgttcacaac aagccatgcc 2109541 cagccagaac cgaagcgtcc agctgctgct gctgcgaatt gctctttgaa tttgtcaaag 2109601 cttccaaata cactgttaat ctcttcagca agcgcgccag tcggttcgcc tccgccgttt 2109661 ggagataaaa gtgtccagaa taatttgtgg ttcgcgtgtc cgccgccgtt gttgcggact 2109721 gcagtgcgga tgttttcagg aacagaatca agatctgcaa caagctcttc aactgatttg 2109781 ttggcaagag cagtgtttcc ttcaaccgct ttgtttaaat ttgtcacgta tgtgttgtgg 2109841 tgtttcgtat ggtgaatagt catagtttcc ttgtcgatat gcggttctaa agcatcgtac 2109901 gcataaggta attctggaag ttcgtaagcc atgataattc ctccttagta tatatgtact 2109961 gaaatgccgc ttcacagcga gcctttcttc attcaatgta acaaaagaat gctttgtaat 2110021 caatgaaaaa gctcacgatt tggctcattt cagcggacat atttcacttt aaccgataat 2110081 ctgccccatt aaacctgccg ccagcatttc ttataggacc gtccataaaa agtaaccgat 2110141 catcaaaagc tgtatgatgc cctttgcaat aacccctgtt aaaaaaccaa tgagtgagcc 2110201 gaggccaatt ttaaacgctg actttaagtc cttctgatgg acgataagtt ctgcgcaaac 2110261 agccccgata aacggcccca atatgatccc tgcaaccgga atgacaaaag gcccgattaa 2110321 taaaccgatc gtgcttcccc atatggcagc tttgcttcct ccgaaccttt ttactccaag 2110381 cagattcgac acgtaatctg ctgcgaataa tactgcggca aaaactgcct caacaagcca 2110441 gaacatataa gaatacggac tgaatgaaaa taaaaatccg tacaatacaa atccggcaac 2110501 aataaatact acgctaggaa taacaggata caccagcccg ataaaggcaa tgataaaaac 2110561 cgctgcaatc aacagccaat acaacatatc catagcttcc atcctcccat tttactctgt 2110621 cttcttcatg tcttccttgt attcacacgc atgcaacgat acaataagca acatatatta 2110681 gtttagctag gaagtgaaga tagtgaatgt gtttcagctt ttcattaaaa gtacatactc 2110741 tccccgtgat attgcaaaaa caagatttca aggaatcgga aaagcgattc tttatgtatt 2110801 tttgctctct gtcctgtttg caatccctac cgcttattat gtaagtacag ggaccgtaaa 2110861 atcaatgaac ggctttaaaa ctgttttaaa caaagatttc cctgatttca caatttcaaa 2110921 cggcaaactt caaacggatg agaaaaaagc cacggaatct caggcaaatg gtttcgttat 2110981 cgtgttcgat ccgacagact cctatggcac tgaacaaatt gaagcaaagc aaaacgcaat 2111041 cggcatcctt cagaacaaat ttgttttggc cattgacgga caagcccaag aaatgtctta 2111101 ctcaatgatg ccgtcagagt tacagaaaaa agatgtcatt gcaggtttaa accaaaataa 2111161 agcgatgatt gtaactgttc tctcagctct tatttttctc gtaacagcag cgggaaaatt 2111221 tattgaagta tcgtttttag cgcttatcgg gttaatcatt aagaattcgc agaaaaaaca 2111281 tttatcctat catcagctct ggaagctttc tgcttattcc atcacacttt caactgtatt 2111341 ctttacaatc atgcgggcac tagaagcaac cgtaccaagt gaatttttgc tgaactggtt 2111401 tgtcaatttt gtcatcctgt ttctcgtttt aaaagagatt ccgtccaaaa aagtaattaa 2111461 taaaagttaa attatattta tttttatcct ttaagtagag agtgtgaaag catttgcatt 2111521 aactttttac ttaagggata tttaataaaa tgtatagagc ttaaacagat acatttataa 2111581 aaaaagctct acaattactc aagaacaagc tctggacaat aatatcagaa gtagtaagat 2111641 gtaacatgaa agaagttctt aacagcattt gacatatgtt tttaacaaaa taagaataat 2111701 gttaaatttt aactaataga ctagttaaaa tcatatggca aaatattttg catcctttca 2111761 caacatattt acataagata gttgctattt aaaaagccag gtaccaatag ggcacctagc 2111821 tttcagaatt aaatcatcaa caagttagaa ttatcttctt tccttctatt ctcattattg 2111881 aactgttatc ttttttgtgg gtttatgtat acaaatgcag ctcccttagc tttcccctta 2111941 tatactgata aacctactgc ccaaggtgtt cctgtcggtt ttggtaattt actgaagtaa 2112001 aactttttgg ttggagttct acttgaaaag taccctgaat attgcgggcc aatgtcccca 2112061 ccctcaacta tagatacacc aaagctctta taatttagtt taccgcattt tccatttgtt 2112121 tcggcgtaag catcaataga tgttgcactc ttagtatatg tataagcatc tgtaataact 2112181 cttattttac aaccagaaat accacttacc ggttgccaac cactgcttgc agcctctgct 2112241 ttttctttag gtgcaactac caaagttaac attagtagca aaattaaaaa cacagaaaat 2112301 tttccttgct tcattttgta gatcctcctt taaactatta cataattatc ctaacagatc 2112361 cattgttcat tgtaaataat ggaatacgag ttttatatta taaaagcctc tttttgatct 2112421 aattttgcac tattttctat tttctatctg aagttaatgt ttagtcgaag aaatcctgtc 2112481 aaaaaagcgc ctgtataaaa accgagcatt cgcagtctct tttcttttgt catgaatcga 2112541 aatggacaag catactatgg tataaaattt cgtatgcggg aggaaaagcg atgaagcgtc 2112601 tcaccttagt atgcagcatt gtttttatac tttttattct tttttatgac cttaaaattg 2112661 gaaccatacc cattcaggac ctccctgtct atgaagcatc agcaaaaacg gctgtacaag 2112721 aaccggctta taaaacggtg aaggtaaagc cgggtgatac ggttatgtcg atagtcggat 2112781 cagcaggttc tccggatgac attgtaaagg attttgaagc actgaatcca aatgtgaaag 2112841 ctaacgccat tcaagccgga acagcgtata aattcccggt ctacccttaa tttaacgtta 2112901 atttcttgtc agttcggcga agacactgtt acaatgtaat ttgtaaaata aattcacata 2112961 aaccatacta gaattgttat atctagaagc ggcaactaca attaaggagc gattgcaagt 2113021 gagtgaaatc acacatcgta caaaaacgcg tcccgtcaaa gtgggacctt taacaatagg 2113081 cggcaacaat gaagttgtca tccaaagcat gacaacaaca aaaacacatg atgtagaagc 2113141 aacggttgcg gaaattaacc gtttggctga agccggatgc caaatcgttc gggtagcatg 2113201 tccggatgaa cgggcggcaa acgccattgc ggatattaaa aagcgcattt ccattcctct 2113261 cgttgttgac atacatttcg attataaact tgcgttgaaa gccattgaag gcggcgcaga 2113321 taaaatccga atcaaccccg gcaatatcgg ccggcgcgaa aaagttgaag cggttgttaa 2113381 agcggccaaa gacaaaggca ttccgatcag aatcggagta aacgccggtt cattggaaaa 2113441 acggatttta gaaaaatacg gttatccgac tgccgatgga atggtagaaa gcgcacttca 2113501 tcacattaaa attcttgagg atcttgattt tcacgatatt attgtcagca tgaaggcctc 2113561 tgacgtgaac cttgcaatcg aggcttatga aaaagcagcg aaagcgtttg actacccgct 2113621 tcacctcggg atcaccgagt caggaacact gtttgccggc acagtaaaga gcgcagcagg 2113681 actcggcgcc attttaagca aaggcatcgg gaacaccatg cgcatttcac taagcgcaga 2113741 ccctgtagaa gaggtaaaag tagcaaggga gcttctgaaa tctttcggct tagcctccaa 2113801 tgctgccacg ctcatctcat gcccgacttg cggccgtatt gagattgatc taatcagcat 2113861 tgccaatgaa gtggaagagt atatttctaa gataaaagcg ccgattaaag ttgctgttct 2113921 cggctgcgct gtaaacggac ctggtgaagc gagagaagct gatatcggaa tcgccggcgc 2113981 acgcggtgaa gggctgctgt tccggaaagg gaaaattgtc cgtaaggttc cagaggaaac 2114041 gatggtagaa gaactcaaaa aagaaattga cattcttgct gaggaacact acgcaaaact 2114101 tgaagctgaa aaagcaaaat taaaagaaga aacacaaaaa gcttgacggg aacccgtcaa 2114161 gcttttttgt gttagaaaaa tggaataata aatattccaa gcactaatga aacgacaccg 2114221 atacccattg cccaggctcc aaggccttga gcacctcttc ttcttgcgat atagccgaca 2114281 ataataccag cagctcccaa taaaacaggc agtacaaaca atgaaatgat ggacaaggct 2114341 aaagcgatgt accctattcc ccgtccttca ttgacattgc cgccgctgcg atcattgtct 2114401 tggtcattgc tgcggtcagc agcacgataa ggctctgcga tttcagcagc tgtttcctca 2114461 aaaaaaccgt cattgtcgcg ggtaatattt gtcccttcag atccatgatc aacatagtaa 2114521 ctgttgttat cacgcttttc gtaatcgttt gccaccttca attccccctt ctgttttatt 2114581 aaaggagctt ttatagtttg atccattttg cctgattcat gtttgctaaa cttttctgtt 2114641 aatgtcaatt gtttatgtta cacttgaagg gatgaaactg aaggagtgtg ggcatgttac 2114701 gcttaggaat agatattgac ggcacaatca cggctcagga tacattcgtc ccttatttga 2114761 accgttcgtt taatctttcc atttcattaa acgatatgac ggattatgat ttaacaaagc 2114821 tgttaaacat tacccaggaa gaattttggg attggatgaa tcaaaatgaa gcgatcatat 2114881 ataaggaagc attgcttgca cagcatgcga aacagtctct cgatcttctc aaagaggagc 2114941 acaagcttat ttatattaca gcgagacgga ctcatttaac tgatattact tatgaatggt 2115001 ttgacagaca aaacattcat tatgaccaca tcgaacttgt tgggggtcat cacaaagttg 2115061 aagcggtcaa gaatcataac atcgacctgt tttttgagga tcatcacggg aacgccatga 2115121 tgattgcgaa agaagccggg ataccggtga ttttgttcaa ttccccttat aatcagcttc 2115181 cgattgattc aaacatcatc agagtaaaca actggctaga agccgttcaa tggatgaaca 2115241 acaacaagca tcacttaata cgcgtcaata actgaaaaag gagcccaaac cgggcccctt 2115301 tttcatatat acgcatttta cgcagtagtg ttttcttggt tttccgctgt acaatcaggg 2115361 catgtgccat aaatctcaaa tttatgcccg ctgacctgat agccatccaa atcatcacaa 2115421 agcttgtcca tcggacatga ttcaatttcc tttgttttgc cgcaggcaag acaaataaaa 2115481 tgatggtggt gatgggtgaa tgaacactta aatcggaaga gcttttcacc ggacagctca 2115541 gttgtttcca aaatcccaag ttcttcatat aaagaaagat ttctgtagat tgtatcaaag 2115601 cttaagcctg gataatcatc attcagtgca gacagtacgt ttttagcggt aagatatctg 2115661 tctgaatcag caaaaagctg cagcatatcc tcccgtttgt ttgtatattt atatccgttt 2115721 tcttttaata ggttcagcgc ttcttggacg ttcatgaagg gtcccccttt tcgctttgct 2115781 taagaacgta tcacatgtat gaaaaagaaa atggcagctg tctgtccagc aagccatttt 2115841 ctttactgca gataaaatta tacccataaa atgaataaaa gtaaatgaaa gcctagtgga 2115901 ttgcgttttt gaattttccg cctctcgttt catgagtatt cataattgtt atgaatgcat 2115961 tttgatcaac ttcaaacacg atcgatttga gctttgtcac ttccagcctt gtgacaaccg 2116021 cgtaaattac gtctttttct tcgtccgtat acccgccttt ccccttcagc ttcgttgtgc 2116081 cccgaccgag acggtgcaaa atcgcgtcgg aaatctcatc atactgctca gacacaataa 2116141 tgacagcttt tgtttcatca agcccttgga tcacggcatc aatcgttttc atcgcaatat 2116201 aataagtcat gaatgagtac atcgcttgct caggaccgaa cacaaaaact gcccaaatga 2116261 aaatgaacac attgatgaac ataacgaact cacctacaga aaacgggagt tttttggtca 2116321 gcaaaatacc gagaatttct gtaccatcca ttgaacctcc atttcgaata acaagcccga 2116381 cgccaaagcc gagtaaaaga cctccgaaca cagtagccaa aataggctgg gttgtaatgg 2116441 cttctacatg gtgaagtgag gattcaataa cggcaagccc gacaatccct ataaacgtag 2116501 agactagaaa ggtcttaccg atatatttat atccgaagat cataaaagga atatttaata 2116561 tgacaacgaa aaaagcgaaa ttcagaaagg ggtttgacat aaagaggtgg tctaaaataa 2116621 gagatacacc gataatcccg ccatcaataa aatcattggg gattaaaaat aattcaatac 2116681 ttacagccgc agatgcagct cctaccagaa tcataaagac cctgaaaata aaatgggtaa 2116741 atgtttcttt cttatgttgt tttgttgggg tcataaaatc tcctttcctg caataactat 2116801 tttaaataca ttataaatct attttaccat taaacactga cacattttac tgatttgccc 2116861 atacattaag tctggaggtg gaatgaccga tgattttatt tcaaagaatt attttgcagc 2116921 ggcttaatca ggctactgct gatgatttgc tgaagtactc aaaacaatac ggaatcagct 2116981 taacaagatc gcaggccgtt gaagtagcga acctgttata cgggaaaaat gtaaacatct 2117041 ttaatgagag tgaacgaatg cggctgctga aacaagtaga gacgattaca tcgaaagaaa 2117101 cagctcaaac agttaatgaa ctattcaaac aatttacaag ctaaaaaatg ggggtgttat 2117161 cccccatttt ttattgctgt aaaatctttt caagcaatgt atcatcaaat tgtttttctt 2117221 tcagcatttc aatctcaaaa cggtatggcg gttttttgtt ctttttatct tcaccgacgt 2117281 atggtgtttc aagaattttt ggaatgtctt ttaactgctc atggtgaaca acatattgca 2117341 gtgcgtcaaa acctatttca ccaaagccaa tattttcatg gcggtctttt ctcgcacctt 2117401 tgacattttt gctgtcattg atatgaagca ctttaatacg gtcaatgcca atgattttat 2117461 cgaactcatt tagcactccg tcaaagtctt cgacaatgtt atacccggca tcatgtgtat 2117521 ggcacgtgtc aaagcacact gacagctgct cattgtgtgt aacgccttcg ataatctgcg 2117581 caagctcctc aaagcttctg ccgcattctg atccttttcc agccattgtt tctaatgcaa 2117641 tctggacatt ttgattcgga tcaatcactt catttaagcc ttcaataatt tttttgatgc 2117701 cggcttcagc tcctgcccct acgtgagcgc caggatgaag gacaatttgc ttcgctccga 2117761 tggccgctgt ccgttcaatt tctgaacgaa gaaaatcaac acccagctca aaagtggacg 2117821 gatttgtcgt gttgccaata ttaataatat aaggcgcgtg tacgataatc tcgtcaatgc 2117881 cgttttcttg catatgtgcc cggcctgctt ctatatttaa gtcttcaatt ttctttcggc 2117941 gcgtattttg cggtgcgcct gtatagatca taaacgtatt cgccccataa gagactgctt 2118001 cctggcttgc agccagaagc atatgttttc cgctcataga gacgtgtgag cctattctca 2118061 gcaacaggtt cccctacttt cttttcttag attggtttct tctctgtttt ttcttgattt 2118121 tctccatctc atagctcatt ttctttttat acccaggctt aaccttcttc ggctttttca 2118181 cgagacgatg agcaatttca tccgcttcat tcggcgtttt tttacgtttt ttgcggcgct 2118241 gacggtcatc gccttttttc cattcgccct tttcaagctc taagtactca aattcgatgc 2118301 ccattttttc aagtcttact aatgcatcct catcagtaag ctcataaatg gtcatcgctt 2118361 gtcctgatga gccggcacga gccgttctgc ccacacggtg aacatagaaa tcgagatcat 2118421 ccggcagctc atagttgata acatggctga cacctttaat atcaatacct cttgcggcaa 2118481 ggtcagttgc aatgatatat gtgaattcca aatcattgat ctgcttcatg acttttttcc 2118541 gctcacgtgg tgttaatccg ccgtgcagca agccgatttt catgcctttg ccagtcagat 2118601 actgggcaat atggtcagcc gtatttttcg tgttggcaaa cacaatcccc aggtatggat 2118661 tcagatgcga catgatgtca aaaaggagct tgtccttgtc acgatgtttc gaaggaatga 2118721 ggatatgctc gattttcgca gcagtcacct gttttggctc cacatgggcg tatttcggat 2118781 tttccatgta tttcttcaag aatggtttca gcttttccgg tatggtcgct gagaacacaa 2118841 gcatttgcag atcctcaggc atgcgggaac cgatgtaatc tacatctgca aggaatccca 2118901 tgtccagcat taaatccgct tcatcaataa caagagattc cgctttatga acacttaacg 2118961 cctgttcttt gattaagtca gcaatccgtc caggtgtacc gacaacaaga tgcggctgta 2119021 ttttcaattt atcaattgat ttttgtttat cagtgcctcc gataaaacat ttcgagcgaa 2119081 tctgacttcc ttcttcaccc tgcgtgattt taagcgcttc ctgataaatc tggttggcaa 2119141 gctctcttgt cggagccgta atgactacct gaacgacatc cttagcagga tcgattttgt 2119201 ttaataaagg cagtaaataa gcgtgagtct ttccagtacc cgtctgagac tggccgatga 2119261 cgctttcttt ttttaacact gcaggaatca gccttttctg gatatcagtc ggttcgtaaa 2119321 aaccaaggcg atgtactgca tctataataa atggtttcaa ttcataaagt tcaaatttcg 2119381 tttctttcat ttttcccagc tccttaaagc ggcacattat gtgtccatca tcacattata 2119441 cccgattttg cttaaaaaca ccacgtttgc aaggcgtttg ttttattcag ttatgtaaag 2119501 caaataccgc agcccatgca tattctaata gcagagagag ctgaaaggag gtacaagtat 2119561 gttttcaccg cagcagccaa tgagaaatta cccacagccc ggaccgcccc gccccatgcc 2119621 aaatcagcga atgatgggca gaagaccgcc taatatgcga ggaccttcat ttggagcaca 2119681 gcagcaaggt tttcagcaag ccggacaatt tcttcctcag gcaaatgccg gagcgagaaa 2119741 tggtgcaggt gcaggcggag gcttaaaagg aatgctgtca aggttcctcc ccggcggagg 2119801 aggcgctggc agcgccgggg ttcccggaat tccaggagca ggtgcagcag cgagcggagg 2119861 tgctggcctg caaggcattc aaaatattgc caatcctgca tcattatcca gtatgcttgg 2119921 aaatgtgcaa aaagtactcg gcatggcgca gcaagtcacc cctatgatcc agcagtacgg 2119981 cccattagtc cgcaatctgc cagcaatgat gaagctgtac agccaattaa gtaaaagtga 2120041 tgatactgag acagaggcca atgaggaaag tgaaaaacaa tccgtttcag aagaatcatc 2120101 agaaaaagaa aaagagactg aaacaaaaac ctcagatggg aacaaaaaat caaaaccaaa 2120161 aagttcttct ctcccaaaga aatctaaaac aactgacaat aaagaacaag aattaaaaac 2120221 atctgccccg aagaaaaagg aagctgcctc tcctgctccg aaaagaacat caggcagttc 2120281 aaaaccgaga ttatatattt aacattcttt gatatcttaa gtgagattgg ctataatgag 2120341 atcagaagaa tgcaagaata gagccgtttg attacggctt tttatattgc ctttactcac 2120401 ttcagtattg gaggacaacc gaaaatggac gtaattaaaa tttcaccgcg cggctattgc 2120461 tatggtgttg ttgatgctat ggtcattgcc aaaaatgcgt cgctagataa aagcttgcca 2120521 agacccatct atatactcgg gatgattgtt cataataaac acgtcactga tgcgtttgaa 2120581 gaggaaggga tttttacatt ggacggctct aaccgtctgg acatcttaaa gcaggttgac 2120641 aaaggaactg tcattttcac tgcgcacggt gtttctcccg aagtcagaag aatcgcagaa 2120701 gaaaaagggt tagtcgcaat tgatgctaca tgtccggatg tgacaaaaac tcataatcta 2120761 atcttagaga tgaaagaaaa aggatatcac gtgatctata tcggcaaaaa agggcatcca 2120821 gagcctgagg gagccgttgg cgtagcgccg gagatcgttc acttagttga aacagaagaa 2120881 gatgtaaaga accttgatat ccaatctgag aagttaatcg tgacgaatca aacaacaatg 2120941 tctcaatggg atgttcacga cattatggag cttgtcaaag aaaaatatcc tcatgtcgaa 2121001 tatcaccaag agatttgcct cgctactcaa gtgcggcagg aagctgtatc agagcaggca 2121061 aaaaaagcgg acttaacaat cgttgtcgga gacccgaaaa gcaacaattc aaataggctt 2121121 gctcaagtgt cagaggaaat agccgggaca aaagcatacc ggatcggcga cttaagcgaa 2121181 ttgaagctcg aatggctgaa aggcgttaat accgttgcag ttacagcggg agcttcaaca 2121241 ccgacgccga tcacaaaaga agtcattcgc tttttagagc agtttgatca cgaagatcca 2121301 tcaacttgga caactgaaca taatataccg ctcaaaaaaa tacttccaaa agtaaaagca 2121361 aaaaactgag gctgtaaaag cctcagtttt tttatagaaa tgtaaatgga tttgtatctg 2121421 tttcagaaac aaagatattc acgccaaact ttttatcatt acacattgat gtaagttttc 2121481 tcgtgacgcc ttctttcatg attttttccg cgtaatggcc cggatcaacc acatttaggc 2121541 caagcatcat cgcatcatgg gccacatgga agtataaatc tcctgtgacg taaacatcgg 2121601 ctccctttcg ttttgcatga tgaatatact tgtttccatc tccgccaaga acagctactt 2121661 ttttcaccat gctgtcagca tccccaacca ttctgacacc attgacgtca agcttgtctt 2121721 tcacaaataa agcgaattcc ttgagcgtca tctcattttt aagggttccg acacggccga 2121781 gccctttttc ggcgggagtc tgttcgacag gatagatatc gtaagcgact tcttcatatg 2121841 gatggctttt tatcattgca ttgataacag ccttttcgac gcttttagga aatacagtct 2121901 caagccttac ttcatgaaca agctcaagct ctcccacttc accgataaaa ggcttagctc 2121961 cgtccaatgg cttaaagctg ccgattcctt cagatgaaaa cgcgcaatgg ctgtattcac 2122021 cgatatggcc ggcccccgca tttccgagcg cggctctgac ctgctcttca tattccttcg 2122081 gcacgtaaac tgccagcttt ttcagaggat ccgtataagt aggtgccagc acttccgtct 2122141 cactcagctc taatgcttca gcaagcaaat cattcacacc gccgtccgca acgtctaaat 2122201 ttgtatgagc tgcataaaca gcaatatcat gcttcaaaca cttttcaatt aaccttccgg 2122261 caggctgatc tgttgaaata tgctttagcg accggaaaat tggtggatgg tgtgcaataa 2122321 tcaagtcaac ctctttttca atcgcttcat cgataacgct ctctaacaca tcaagtgtaa 2122381 ccatcacatt tttaattggt ttgtttaagg tgccgatttg caggccgatt ttatctcctt 2122441 caaccgcata ggctttcggg gaaaattgtt caaacagctg gatgatctgc tgcccattta 2122501 cacttttagc catgatcgat tacctccttt aacagctcca ttcgatcggc gagctccttt 2122561 aatttttgtt tgttttgctc tgtatccgcc gcttggctga tctgttcata aatgctttga 2122621 gtgtgctgaa gctcttgtgt ccactttttc aaaaagacag catttttttc ttttgccaag 2122681 aaagggccaa cgagcatccc ggctgataaa gaaataccgt cataagccgc atccctgtct 2122741 cccgcttctg ccaccagcac ctcatagcac tttccgtcct cttcaaggat tacctcatct 2122801 atcagcgcat atctttcttt ataaagccac tccctgatat gaacagcatg aatattcggc 2122861 tgtaaaatga gccgttcctt ccccgttaat ttgtctttgc ccgcttctaa aatgtgagcg 2122921 atcaaagccc cgcccattcc ggcaatcgta atggcatcag cttcaccttt tttaatcact 2122981 tccagtccgt ctccctgcct tacagaaatg tgcgagttta agcctgattt ttcaacctgc 2123041 cgctttgcag acaaaaatgg gccgtctgtt atttctccgg caatcgcccc gctggcttta 2123101 tgattcagca ccgcataaca aggaaggtag gcgtggtcag agccgatatc ggccatcacc 2123161 gctccattcg gtatgtactc cgctactgtt tgcaatcgtt tagataattt taattcgttc 2123221 acttgtcatc acaacttttc tcaatcattt tttcctttac tatcatataa aaaatcagcc 2123281 cggaatccaa gctgaagcaa atgattttga aattatttct tttgatgcgg gtctgcacgc 2123341 agcagtcaaa aataaaaggc tgtcgagaac atctcggcgg cctgtgaatg tataaagaga 2123401 aaaatagttc ttttatttaa tttttgacac ccactctgcc atatcatcca gcttatcggc 2123461 cggaacaaga ccggaaggca ttccattacc gcctttttcg atctttgttt taatttcagc 2123521 gacatctttc ttatccccta caccttttaa gctaggaccc gaaacacctt cataattttc 2123581 accgtggcat gcgatgcagt ttgccttgta aatttcttct ggtgaagcgt ttgcatcttt 2123641 cttttcagca gatttgcttt ctcctccgct cgcaatctcc cgagagtcat caagtccttt 2123701 tactgataaa aagaaagtta gaccaattcc taaaacagcg atcagcaaaa atggaataag 2123761 cgggttccat ttcatttccc ttcccccttt ttgatccttc cccctatgta aacacttcta 2123821 attctaactt atttttacaa aaagtaaatg gattgctata caaaagtttt ttattcacac 2123881 tttatacaaa attgaataga aacatgccta aatctctaat atccttttta ttctattgta 2123941 taatgtattg tatacgctta caatagaaaa tatggaatta gattttgaaa tttttcacca 2124001 caatgttcat ttgcaaatga catcattttt cagtaaaata aaggcatatt atccatatat 2124061 ctttttaaaa aaagaagaac ggatcttcaa gacccgttcc atcttattca aggaaatctt 2124121 tcaaacgttt acttctgcta ggatgtctta gtttccgcaa cgctttggct tcgatttgtc 2124181 gaatacgctc tctcgttact ccaaatactt tgccgacctc ttctaatgtt cttgtacggc 2124241 cgtcatcaag accgaatcga agacgcaata cattttcttc acgatcagtt aacgtatcaa 2124301 gcacatcttc cagctgctct ttcaatagct cgtatgcggc gtggtcagaa ggtgaagttg 2124361 cttcttggtc ttcaatgaaa tcaccaaggt gcgagtcatc ctcttcaccg atcggtgttt 2124421 ccagagatac cggctcttga gcaatcttta agatttcgcg tactttttca ggcgttaaat 2124481 ccatatcttc cgcaatttct tcaggtgttg gttctctgcc taagtcttgc agtaattgac 2124541 gctgcacacg gattaattta ttaatggttt caaccatatg aacgggaatc cggatcgttc 2124601 tcgcctgatc ggcaatggcg cgtgtaatcg cctgtctgat ccaccacgta gcatacgtac 2124661 tgaatttata acctttgcga taatcaaatt tttcaacggc tttcatcagg cccatgtttc 2124721 cttcctggat cagatcaagg aacagcatac cgcgtccgac ataccgtttt gcgatactga 2124781 caacaagccg caggttcgct tcagccaatc tgcgtttaga ttcttcgtca ccttcttcaa 2124841 tcttttgagc gtaggcgatt tcttcttttg cagaaagaag gttaacccga ccgatttcct 2124901 ttaaatacat acgaactggg tcattgattt taacgccagg cggtacactt aggtcattaa 2124961 ggtcaaattc ttcttcggct ttggcaagct gctgaatatt aggatcttct gtttcttcat 2125021 tctcactaat taattcaaca ccttgttcac ctaaaaattc ataatactca tccatttggt 2125081 ctgattcaat ttcaaagctg gacatacgct cagcaatttc ttcatatgtc aaaacgccac 2125141 gttttttacc agactctgtt aattgctctt ttacttggtc gaatgttaat tctgtctcgt 2125201 gggtttgttt atcagccatt atggatccct ccttccaaag cttgcaacga attctataag 2125261 cggtatgatt cttattcggt ccattcaggc gttttctatg tgaactgcct ttaacaatgt 2125321 gcgaataatg aaatgacaat tcatgatgag gttaagcgat ctatttgctc ctccgcaagg 2125381 aatcattgcc aataaatgct cctcatcagt tctccagtta ttttaaagat cggttcaatg 2125441 taacgatttc ttgagccaaa gaagcagctc ttaaaaaatc tttttgcctt tctgcttcgg 2125501 ctctttccgc ctctttttct tttatcattg accaatttct ttgattcaac acttttttta 2125561 cataatctga taactcggct tcgctaagct cttgattaac ctgaagcatt aatatatcgg 2125621 acaagagctg gcttatatga tcatccgtca ccctggccat cagatgctga ggcgtcagct 2125681 cggctccctc ttcataaaaa gcataaagat aagcggctaa tgcccggtgc tcatcaatat 2125741 taaattgaaa ccctacccgg tcaatcactt ttttgatgac gctccgatct cgaagcatgt 2125801 gagcgagtaa cagcctttct gcattttcat acgccggacg caaacgtttt tgccttgctt 2125861 ttgtcgtcag atgcgctcgc cgcgttttag tttcaccgct attgtcagca ggtttgtttt 2125921 gcttgctgaa aacagacagc tgctcagtta aagactcctg tgaaagcgaa aactctgaag 2125981 caagctgctt tacatagact tcctgctcta gagaccctga aagcgtgctg atttctttca 2126041 gtacgtcttt aatgtaagct aggcggtcgc cttcatcgga caggttcttt ccttttcgga 2126101 aatattgcat tttgaacgcc attacggtga cacttgcgtc aataatgtcg tttttaaatt 2126161 tttccccgcc gaattttttg atgtaatcat cagggtccaa tccgtcagga atcattgcaa 2126221 ctctgacttt gcagcctttt ttttgcagaa gctccgaagc ttttaaggtg gcttcataac 2126281 cggctttatc agagtcatag caaagaatga tttcttcgac gtttcttctc aggatcttga 2126341 catgatcatc tgtaagagac gttcccatcg tggctatgct ttcctttaca tccgagctta 2126401 cggccgatat gacatcagca aacccttcaa ataagactgc tctttcctgc tttctgatat 2126461 gaaggcgggc cttataaaaa ttgtaaagca gtttgctttt atgaaagagc ggggtttcag 2126521 gactgttcat atacttaggc tgctggctgc caagagccct gcctgagaaa gcaacaacag 2126581 ccccgtgatg atcatggatc ggaaacatga cacggtttct gaagcggtcg aaatatccgc 2126641 ttccgtcttc gcgtctgatc aggagacccg ctttttccat ttgcgcctca ctaaatcccc 2126701 tctttacaag gaatttcgtg ataaagtccc aagaatcaag agcatagcca atctgaaatt 2126761 cattaatcag ctctttcgta aagcccctag aaagcagata atccagtgcc tcttgacctt 2126821 cttttgtatt tattaacaaa tgatggtaaa atttcttcag gagctcatgt gcctcagcca 2126881 ttttttgttc tccagaagac tctggccggg ctccggaatg gactgttata tcatctggaa 2126941 aatcaatttg gtatttgtca gcaaggtgag aaaccgactc ggcaaaagaa tagccttcca 2127001 tctgccttaa aaaagagaaa acattgccgc ccgctccgca gccaaagcaa tgaaaaatct 2127061 gtttgtcggg cgatacggaa aacgaaggtg tgctttctcc atgaaaagga cagagtccaa 2127121 agtagtttcg gccttgcttc tttaattgaa cataatcacc tatgacttca acgatatctg 2127181 ccgacttttg cacctgatcc acaatttcat ctggtatccg atttcccatc ttataacact 2127241 ccgtcgtaca ttattcgatg ctttagtgca aaatcccttc atcgttcgac aggatttttt 2127301 gcagcagtgt aataaatcgt tctcgatctt ctttattcaa ttttttaggc cctttggcat 2127361 atacgccttt tcttctttgt ttgccggaaa aatgacggcc ctctagggca aaatcaatcg 2127421 tgtcttcctt gtaaagacga cctctttccg acataacaga gacatttctg ttcaacagca 2127481 gagatgctaa tccgatgtcc tgcgtcacaa caatatctcc cggtttcacg tgatttgcga 2127541 tatataaatc agcagcttct ttatgaggat caacatactt ccatttttct tcattgcttc 2127601 tggaaagctg ataatgttca aatgaagcga caaaaagaac ttgaacttca tactcggatg 2127661 ctgtttgtaa aatttcatct tttaccggac aagcatcagc atcgacaaaa atcgtctttt 2127721 cttgttcatt aagaagagta attctccatc cctccattaa actcctgcat aaaagcaagc 2127781 aaaatcgcac atcctttatt attgtggatg tatatgaatt tgtcgaaaaa tttccgggag 2127841 aaattcttga catcttaccc ataatagttt attcgtatca cacgatcctt aaacctaaaa 2127901 ttaatcattt tatcacaatt ttttattata atacaaactt cacaaagatg ctattgtttt 2127961 tcattattcc cttttggcac agccaaaaac ccaggataga gcgtcctgag ttatatgttt 2128021 tttgttttga gatgatggat aatatttgct gtttcctcaa ccgctttatt tgaaacatca 2128081 acaacctggc agccgatccg atccacaatc ttttcgaaat actcgagttc ctctttgatt 2128141 ctgttgatat ttgcataaat cgctttatca ttaagcccga gtgattttaa acgttctttt 2128201 ctgatatgat tcagtttatc agggctaatc tttaaaccga tgcatttttt cggatcaacg 2128261 ttaaagagtt cttccggcgg atcaacctcc ggtacaatcg gaacattggc aaccttcagg 2128321 cgtttgtgtg cgagatattg agacagcggt gttttagacg ttcttgacac gccgatcaaa 2128381 acgatatcag cttttaaaat ccctcttgga tcacgtccat catcgtattt aactgcaaac 2128441 tcgatggcct ccactttttt gaaataatct tcatcaagct ggcgcacccg ccccggttcg 2128501 tatttcgctg ttaaaccgta ggctgtttcc attttatcaa tcaacgggcc gataatatca 2128561 taatataaaa catttgcttt ttccgcttcg gctatcaaat attctctgat ttccggcacc 2128621 acgagtgtaa aacagataat gccgccgtct gcctttgcaa gtgaaatcac ttcattgata 2128681 gtgcctatat cttcaacata aggaattctt cttacatgag tatcatccgc cgatccgtta 2128741 aattggctga gtgctgcttt tactaccaat tcagccgttt caccgacgga atccgataca 2128801 acatagatga tgcggttatt catattatcc ccccgttagt ttgcaatctt ataggatttc 2128861 attttcagat aaactgacaa gtattttggt catatttgtt tttgtcactc tgccgatcac 2128921 ttcaaagcct ttatcggtgt ctttgatgac aggcagtgca tcaatttgtt tttctattaa 2128981 gtgctttgca atgtccatca cataatcctc gcgtctgcac accgtaatgt tcggcatcct 2129041 tgtcatgatg atgtgaacag ggaccgatgt aagctcctgc tggccaatgc tcgctctgag 2129101 caagtctttt cgtgaaagca ccccgactaa aacagcatcg cggtccacca caaacagagt 2129161 acctacatct tctaaaaaca tggtgcaaat cgcatcgtac acagaaacgt tttcgtgaat 2129221 cactacgggg atagattgaa agtctttcac ctgaagcttt ttgagtttat ccgccaaaag 2129281 ctgtgtgccg gtttttcccg tatagaaata accgactctc gggcgcgcct cgaggaatcc 2129341 tgacatggtg agtatggcta aatccgggcg caatgtcgcc ctggttaggt tcagcttttc 2129401 tgcaatatgc tcccctgtaa tcggcccgtt ttcttttaca atctgcaaaa tatgttcttg 2129461 ccgtttattt agttcgatcg tactcaccac cttttcactt catagctatg taaagaaata 2129521 acaatccata ttataacgta aatatcttgt aatcaaacaa aaaacttata aatggggaaa 2129581 agacgattac cgatcacaca gcaaccgcct tttctctctt tattttacaa taagggcatt 2129641 catattcgca aaggacttga tctcatccgc caagcttacc atttgcgcta aacgatttgc 2129701 ctttaatgac tcattatccg ctataaccat tgtatgatcg aagtaagcat cgatcggttc 2129761 ttttaaggct gcaagtgaag caagcgccgc ctcataatct tttttgctga agttttcctg 2129821 cagattttgc ttcgctgttt ggtaggcatc aaacagtttt gcttcgtatt cattttcaaa 2129881 cagatcaggc tgaatgtctc cgcggactcc ttttttgctg atagagatca ctcggcctaa 2129941 cgcttcggct gtttccttaa agccaggtgc accaagcttt tgctccagta cttgtgcttt 2130001 atgcagcgca gagtacggct caagctcaga gctttccagc acggcgtcaa tgacatcatg 2130061 tctgatttgt tcagcattca agacatattt caagcgctga gtgaagaaat ccagcagttc 2130121 attttcttta tcggtttgaa cgaaagtaag cagctcttca aatgaaattc cccagttgcg 2130181 gtcaagaaga atcgcaacaa taccgcttgc ttggcggcgc agtccgtaag ggtcctggga 2130241 accggtcgga attacgccga tagagaagaa tgaagcgatt gtgtcaagct tatccgccat 2130301 tgctacaaca gctccggtga aagtagaagg cgtttctccg cccgctgatc taggcatata 2130361 atgttcatta actgccgcag ccacagcttc atcttcgcca agcattctcg catacttttc 2130421 gcccataatt ccttgaagtt cagggaattc atatatcata tgcgtcacaa ggtcgaattt 2130481 agaaatttca gcagcccgct tcacatgttt taatgtatct tcatcagcct gaagacgaac 2130541 ggcaagtttc tctgcgattg atgtgactct cctaacctta tcagcaagag aaccaagctc 2130601 ttcatggaaa acgatatttt caagcttctt cacatttgca tcaatgttta gtttctgatc 2130661 ttctttgtag aagaatgaag catcagataa acgtgcgcgc agcacttttt cattgcctcg 2130721 ggccacattt tcaatcgcgt ggctgttgcc gtttcggact gtgataaagt gaggcagcag 2130781 gtcaccgttt ttgtctttga cagggaagta gcgctgatgc tctttcattg tcgtgacaag 2130841 cacttcttca ggaattgaca gaaactcgga ttcaaatgaa ccgtaaagag ctgtcgggta 2130901 ttctactaaa tgattcactt catcaagaag gtcttcgtca actggaatgc tccaattgtt 2130961 ttcagcagcc attgtttcca gctgagattg aatcatttgc tttcggacgc taggatcagc 2131021 aataacatgc tgtcctttga gctgctcttc ataagctgaa ggtgattcaa ttgacacttc 2131081 atgtccgagg aaacggtgtc cctgtgttgt ccgtccagac tcaacgtttg tgatcgaaaa 2131141 tggaatgaca tcctgtccaa ataatgcgac aatccatttg atcggtcgga tataacgcaa 2131201 atcttcattt ccccagcgca tgtttttcgg gaaatgcaag cttgtaatta aaccgctcaa 2131261 ttctggcaga agcgacttcg tttcttggcc ggcttggaat ttttgcacga atacatactc 2131321 tatgcctttt acttctttga tgtacaggtc ttccacattt gcgccttggc cttttgaaaa 2131381 gccgattgcc gcttttgtcc agttcccgtc cgcatcaagg gcaatttttt tcgcaggccc 2131441 ttttgcttct tcttttatat catcctgctt ttctgcgaca tccttaacga acacagcaag 2131501 acgtctcggt gtattgaaga gtttcacttc accgtgagta atattttttt ctttaagcca 2131561 gcctgtcagc ttgtcgccaa gctgaaccat gctttcattc aaaaagcgcg ccggcatttc 2131621 ctctaatccg atctctaaaa gtaaatcctg tttactcatg agaagaaccc tcccctttaa 2131681 gcattgggaa ccctagtttt tctcgttcct catagtaggt ttttgctact tttctagcta 2131741 aattccgcac tcttgcgata tagcccgtcc gctcggtaac agagatcgca cctttggcat 2131801 caagcaggtt gaaagtgtgc gagcatttca gcacatagtc atatgctgga tgaacaagtc 2131861 cgttgtccat ttgcttgatc gcttcttttt catatgtgct gaacaattgg aacagcatat 2131921 cgacgtctga tgtttcaaac gtataaacag aatgctcata ttcagccatc atgaataaat 2131981 cttttactgt aaaccctgac gtccattcca agtcaaacac gttttcttta tcctggatat 2132041 aagacgcgag acgctcaatt ccatacgtaa tctctacaga aacgggttta cactctaatc 2132101 ccccgacctg ctggaaatac gtaaattgtg ttatttccat tccgtcaagc caaacttccc 2132161 agcctagacc cgcgcagcct aaagacggat tctcccagtt gtcttcaaca aagcgaatat 2132221 cgtgctcaag cggatcaatt ccaagagcac gcaaggaatc caaatacagc tcttgaatgt 2132281 tatcaggtga cggtttaata atgacctgga actgatgatg ctgatacagt ctgttcgggt 2132341 tctccccgta gcggccgtct gccggacgtc tggaaggctc tacataagcc actttccacg 2132401 gctcaggacc gatactgcgc aaaaatgtat acgggctcat cgtgccggct cctttttcta 2132461 catcgtaagc ctgcataagc acacagccct gactggacca atgcttttgc aaggttagaa 2132521 tcatgtcttg aatattcatt tcaagcacct ccacttttct ttcataagtt gactgcggca 2132581 gcaaccaaaa aactcccgtc tctatgcttg ccagccgcaa acatagggac gagagttctc 2132641 ccgcggttcc accctagttg ctgagaacaa aatcccagcc tcttttttaa aattgctcaa 2132701 gaatgccttt cgttgcgtgc tcatccttag cttacaccgc cctaaggtcg ctttcatgag 2132761 gtaaacgcaa gtacttcttt ctctcactgc aacatatttt ataataaatg atcatataaa 2132821 aagatggacc aaatgtcaac ttttgttttc acccataaga tgtttcatgc tttccatttg 2132881 atctaaaaag cgctttgatt ttaaatacaa tcccgaatat tcttcgtaat ataaatcaat 2132941 cacttgcttt aattcagctt ttgtttcctc ttttaaggac acattgccga gtctcgacag 2133001 atcaaaatag taaaagagcc ttaacagcct tgccgtttgc ggtttaatcg gtatcctgta 2133061 aggatctttt tcaaaacagc ggtggcatat aaaaccatta tcacgaacag agaaatgaaa 2133121 ggttccgtct tggcttttac aatgtacaca atgattcagc tcaggataca ggcccatgac 2133181 accgagcatc ttcatttgaa caatgaaggt gataacatcc ggatctgttc cttcattcaa 2133241 ctgttttaat gattctaata tgaattcaaa taaataagga tttggctttt tttcttctgt 2133301 gcctctgtcg actaactcag caacataggc agcatatgct gttaaaaaca agtcttccct 2133361 gatgcctctc atgctgagga tcatttcccc ctgctgaagc gttccgaggc ccgatgtttt 2133421 ttgcattaag aaagaaccat acaaaaaggg ctggctgact gctgataaac ggctgttcgg 2133481 ttttttggcg cctcgtgcca taacacctat ttttccgtgt tctcttgtca gtaatgttac 2133541 gattttattc gtctctccgt aatcatttgt gcgaagaacg atcccttcac attttgtcag 2133601 catttccgca ccttcctcaa gcaggagcgg ccaagaggtt tataaaattg gataatcaaa 2133661 tcgggctagc tcatcttcta gttcttcggg tctttccatg ttctcttttt ccagttcttt 2133721 aaaaagaaga tacgtatcaa catttcctgt ttgagaaaat acgttccagg taaaattcaa 2133781 cacaagaaac ccacctttct gtagttaaac tagcttacct aaactccaaa ttcttacctt 2133841 tatcttgacc agatgtcctc catttcatgt taaacaaaat ttgctaatgt atccctgttc 2133901 ctgtgagata atgacacaca cgggaagaga ttaatattcg tcctctttaa agccaaaatc 2133961 gcgaagctgg gacattttat tacgccagtc tttctgcact ttcacccaca attcaaggta 2134021 gacacgggag cccaacagtg cttcaatatc cgctctcgct ctttttccaa cctcttttag 2134081 aaggcttcct tttttaccga tcacgatgcc tttctgggaa tcccgctcga ccacaatcgt 2134141 tgccgctacg tgcacagaac cgttgtcctg ccctttgatg gattcgatgg ccaccgcaat 2134201 gctgtgcggg atttcttctc tcgtcaaatg cagcaccttt tccctgatta attcagaaat 2134261 gataaatcgt tcagggtggt cagttacctg gtcactcgga tagaattgcg gcccttccgg 2134321 caaatacgct tcgatctgcg cgagcaaggt ttcgatgtta tttccttcta aagcagaaat 2134381 cggaacaatt tccttaaaag gataacgttt gcggtattcg tcaattagca gaagcaattg 2134441 gtcgggatga attttatcaa ttttgtttac gattaagaat acaggcgtag acatcgtctg 2134501 caatttctca atgatgaatt cgtcgccctt cccgtagcct tcctcagcat tgatcataaa 2134561 caagatcaaa tcgacttctt ttaatgtatt ttgcgccact ttcatcataa agtccccaag 2134621 tttatgctta ggtttatgaa tccctggtgt gtcaataaaa atggtttgtg atgtgcctgt 2134681 cgtcagtact ccttgcacct tgtttctcgt cgtttggggc ttatcgctca tgatcgcgat 2134741 tttttgtcca atgactctgt tcaaaaatgt agattttcct acgtttggtc ttccaataat 2134801 ggatacaaat cctgatttaa agctttcgtt cgtcatgtaa atcctccgat gaaaatgcgc 2134861 ctggcaataa ttcttccaca gtcatttctt ttatttgtcc ttgtaaatta gtcagtacga 2134921 caataacgtc ttttgtgcaa agctcagaaa tcacctgtcg gcaggctccg cacggagata 2134981 ctggtccagg ggtgtcagcc gcaacggcca gcatctgaaa ctctgtatcc ccttcagaaa 2135041 cagctttaaa taaagcggta cgctcggcgc aattgcacat gctgtatgcc gcgttctcaa 2135101 tattgcagcc tctgtacact tttccatcct tggtaagaag agcggctcct acttggaatt 2135161 tggaatacgg cgcatatgcc atatcacgcg cttttaaagc ttctgttatt aattcttgtc 2135221 tgttcatgtg tacattcctc tcttacctat aatggtaccg ctatcacttt atattttaca 2135281 taatcgcgcg ctttttttca cgcccatttc taaaaatgta aaataaatgt aagaattttc 2135341 agccattaca gctttggcaa aaaaataagt aaaccaatga tacacgaaat cacggcaaaa 2135401 acgcaaacag ccccggcggc agcgtccttg gccgctttag caagagggtg atgtttgtca 2135461 gttattaaat caaccgtatg ttcaatggct gtatttaaaa gttcaagcga aaacatacca 2135521 cctatcaaaa ggaatataat catccactca ataatgctga gctctacaag gaagccgcaa 2135581 atgagaacag cgcaggcggc tgcggcatga aattggaaat tccgctccgt ccgcgctgtt 2135641 tcccatatgc cccggcctgc atgcacgaag cttttgaaga atcgattcag ctcatttcta 2135701 tgatcttttg agtccataag cgtccagcaa ttccttttgc ttagtaaaca tctcctcttc 2135761 ttcctctttc gtcatatggt catatcctaa aaggtgcaga aatccgtgta cagctagaaa 2135821 tccgagctct cttttaaaag aatgattata ctcctctgcc tgctctcttg tgcgatcggc 2135881 actgatgata atatcaccta aaaccggagg catttcggcg cccacgattt cgatctcgcc 2135941 ttctccctct tcttcaagag caaatgagat gacatctgtc ggagcatcct ttccccggta 2136001 ttctttgtta atctgatgta tgtcatcatt ggaaacaatc gtgacagaaa cttcagcctg 2136061 atcctgaacg ccttcacgct cagcggcaaa ttgaagcaga ttttctactt ctttgagcat 2136121 ctcttctgag acgcttcccg tttcatcaac gatatcaatc agtaaactca tctatttcac 2136181 cttcttagta gcctccggat attcaatccg ggagtggaaa attcctttta atgttgcaca 2136241 gagcgttttt gcgattgtat ccagctcttt aaatgtcaaa tcgcattcac tgaactgtcc 2136301 gtcctgaagc ttatcggata taataccccg gacaagcttt tcaattcgtt caggatttgg 2136361 attgtgcatg gatctgacgg ccgcttcaac actgtcggcc actgatataa ttgcggcttc 2136421 ctttgactgc ggcttcggtc ccggataacg gaactcttcc tctgtaatct ggtcgccttt 2136481 ttccttcgct ttatagtaaa aaaactttaa aagcgaggtt ccatgatgct gctcagcaat 2136541 atcgacaagc tctttcggaa atttatagct tctcagcata ttcgcaccgt ctgtcgtatg 2136601 cgagataata atatttttgc tcaactgagg tgacagcttg tcatgcggat tgtcaatatt 2136661 catttggttt tcaataaaat attgcgggcg ctttgttttt ccgagatcgt gataatatgc 2136721 gccgactctt gcaagcaaac cattagcccc aaccgcttca caggctgcct ctgataaatt 2136781 ggcaaccatt acactgtgat gatatgtacc tggtgtttcc gtcagtattt tgcgcaatag 2136841 cggatggtta ggattagaca gctcgagcag cctcatggtg gataaaatgc caaagcccgt 2136901 ctcaaaaaac ggcatcagac cgatgatcaa tacagatgaa gcaaaccccg acacaacccc 2136961 catgagcatt aacgtgccga tttcaagacc cgacagcgca gtgttctgga tcaataataa 2137021 ggatagaacg acaaccatat taataaacgc cacgaaaagt ccggtctgca aaatctttga 2137081 tcttgcattg tgttttccta aaaataatac acctgaaatg ccgctgatca aataataaat 2137141 ccctatgaca taattgaatg ttcctgtcac accctgatta aacatcatac ttccgcaaat 2137201 cgcaagaatg atacttccca aaatggcaat gcgttcattc atcagcagtt tgattaagat 2137261 ggcgccggcc gcaatgggga ccagatagcc gatattatta tactccatct tctgaaacaa 2137321 actgacaacc tccatgatca caagcaaaag tgttgtgatt atggagaata acagaatgga 2137381 ttggttttta aacttcagat tttgtttctg tttttcaaaa taatatacaa gtgttgcaat 2137441 gaaaagtccg atcataatca atagcccgct gatcggttta aagagatttg agttatttaa 2137501 taacccggtc agctcaagtt tcctgtacac ttcccgatca atgaggtcat tttcttccac 2137561 gagcacttgc ccctgtttga tttgaacctg ctggacatta tctgaggctt cctgccgttt 2137621 tgcctctgtt gctttcggat cgaagacgta attcggaata atagcaaaac gcccgatttc 2137681 tgtcgcggct cccaagtatt tagacggaat agaattgctc tttagctctt tttctacctt 2137741 atcctttgca tcagatagtt tatccgaagg gatttcactg ctcatgaccg tatttaccgc 2137801 ggtaatgacc gtatctctga caaaagaaaa gtcttcactg tctgctttca gcaatgtctt 2137861 gatggaatcc tccgatatag aatcattcac atctgatgtc aatttgtcct ttacagattt 2137921 gaccattgat ttttccgatg gtgatttact gccttcttcc gatgattttt tcacttcact 2137981 aatactgtcg aatattgatg acacaaggtc aatccgattg tctgtatatt ctttttttaa 2138041 tgtatattga tcttcaaccg cgtcctcagc ggcttgcttt ttttcctctg tggctttttg 2138101 atcttctacg gttgccggag cgtaaatggt cttgtcgctg actgaaaaca ggtctaaatc 2138161 aagtgtttcc ggcttaacat gtacaaagag caaagcaaac ataatggcag ccagcagaag 2138221 atacagcagt acatgcatgg agcgggcatt tttaaaactg ctccattttt ttgagctgct 2138281 tttggtctta gccttctttt tcaacacaag aacctcctct tgaaacatca agcccataag 2138341 caatcataaa aatgacccga taacgcgcga tcgggtcatt cagcattaat tttgcttatc 2138401 gtatgcttca ataattttcg caacaagcgg atgtctgacc acgtctgtct ggtctagctc 2138461 aatcatagaa atgccgtcta ttcctttcag catctccttc gctactgcaa gtcccgattt 2138521 gacgcctttc ggcagatcaa tttggctaac gtcacctgta atgatcattt tagagccaaa 2138581 acccagtctc gtcaaaaaca ttttcatttg agcaggcgtg gtattctgtg cttcatcaag 2138641 tataacataa gcatcatcga gcgtccgtcc cctcatatat gcgagcggag caatttcaat 2138701 gatgcctctt tccatcagac gttctgtatg atctgcccca agcacatcat ggagagcgtc 2138761 atacagcggg cgcaaataag gatctacttt ttcttttagg tcacctggga gaaaaccaag 2138821 gctttcaccg gcttccacgg caggtcttgt taaaatgatt tttttgatat gtccgttttt 2138881 taaagcatgg actgctttta cgacagccag gtacgttttc ccggttcccg ccggaccaat 2138941 gccgaataca aggtcattcc gcttcatagc ggccacgtat tcccgctgtc ccattgtttt 2139001 tacacggatt gatttgcctt ttgcgttttt tgtaatttct tcttcataca tgctttcaaa 2139061 gtattcaagt tcattcttct ttgccatttt gatggcgtaa atcacatcac gttcagagat 2139121 ctctatcccc ttgcgaatta aagcgaggag cgatcccagc agcctgtctg caatctgaaa 2139181 cgattcatca tcgcctgaaa cataaatcgt ctcgccgcgc gtaatgatat ttaaattcag 2139241 atctttctcc atcaatttca aaaaagaatc ttggttcccg aagagtgaaa gcgcctcgtc 2139301 cgggtttttc agtttttgat tcatcgcaag taaatgttct gtcattcttc agtctccctg 2139361 acaataggtg tggtttgaac gatatcttct ataacttggt agagaataat caactttact 2139421 ttaccattct caacagtctg gtgcaaaact ttttcacttt tcacctcgcc gttttcgcct 2139481 attttatcct ctacatcctg tttacccaat ttaatgcctt cttgaactgc ttcttctttt 2139541 gtatattttc gcaaagcctc ttcactttct ctcgtttgct ctttgacata ggatacaggg 2139601 agcttaaatc cgagaaaatg aagcgaatgc ttttcttgtt ctgtttttgg atgcttcaat 2139661 tcctcttttt taaacgtcat cccccagatc gggattgcca aagaaccaaa agaaagcttg 2139721 tgctttgtcc ttactttgcc cgtatagacg ttaaataatg tttcaagcgg gactgtcact 2139781 tctgatctat accaggtttc tccataaatt tctgcttttg aggcgacttc ctgctgatgg 2139841 tcttcgctgc cgatcagtcc cgaaacaagc agctgtccct tttcaacatg atcgtgtatg 2139901 gcggccatgg gctgtccttt ttgcacaaac attctcgtaa tggttgcttt ctttttggcg 2139961 acaatattgc gcgggctaac atatttttct ttttcgggct catttttctc cacaactttc 2140021 atatgaatgg tcgtcccctt cagatcaact ccgacccaag tgatattgtc tattccattg 2140081 gttaatgatt tctgtatttt ttcgggcgac atcattaaaa actgcagacg gccctttttg 2140141 acgccgattt cattaagatg ctgcctcatt tgatgttctg tttcaggctt agcgcctgtc 2140201 acatcaattt tccacaccat attggacagc aaaaacaaaa gaatgaaaaa aatcgcaaaa 2140261 ccgatcgtaa accctatatt cagctttgat ttcagcaaca ggaagggaaa tcccttccga 2140321 ttgataaatc gggctttaca tttaaattta cttcttaccc gccgaaaggc atgtacatcc 2140381 tgaagctgta tatataacga tacggcttct ttcttttttt tgacatgaaa gaccggaatc 2140441 ccctgtcttg tgcattcatt aaggagccgc tcaatccctc ttcccgtcaa ttcaagctgg 2140501 accttacccg aaaaaaaaga cagccattta tttttcacaa catttccccc tcggctttat 2140561 gactcaacat atcgaacgac atcaatcgta ccctccaaaa gtatctcttc cggaagaatc 2140621 gccttgatga caaaattttt accagatatg atgcactggc cctgcttcag catcagccgc 2140681 acttcattct cactgaaaag caaaaggcct ctgtggtttt ctatgtagat atgaagtctg 2140741 ccaaccattg taatcctcgg cagatccatc ataacgtccg ggggaatttc caatgctctt 2140801 gtcagccaag ctttcatacg attctttctt tgccccatac aaaaagaacc ccctttcatc 2140861 tcatatgtat gatttgaaag gaggttctaa cactttaatt tttacgggcc gggcgcatcg 2140921 tacggtgagg ttttttcgcc cgtggaggtc cgaacacctc tcctagaacg atcccctgta 2140981 cgacggtgtc tttattcacc tgaagcattt tttgttttgt gtatactgtt ttttgtttgg 2141041 cagcagcaag atctcgttcc agccctttca ggtttcttgc tgtttccctg cgtctttctt 2141101 ccgcttcccg tcttgcctgt tccatacggt tagggatagg tgcaggggca tcttcttttg 2141161 actgcttctt ttgaggagaa gcagattgca cgtgttgagg tttttttctt ttttggctgt 2141221 tttgcttttc ttctttgctc tttttgccga aaatcgcaga aatgattccg atgatcgctg 2141281 caataataag cggattggtc agtaaatctt ccatcagcgt tctcccttct tagagagatt 2141341 atgatttgcg gtcttcatcc gaagggtctt tcgtcagctt gccgaatgaa tcacgcattt 2141401 ctgtgtcagc atcgatgttc ttgatattca tgtaatccat gacgccaata ttcccttcac 2141461 gcaaagcttc tgccatcgca agcggcactt ccgcctcggc ttctactact ttcgcgcgca 2141521 tttcttctac gcgggcacgc atttcctgtt cttgagcgac agccatcgca cgtcgttctt 2141581 ccgcttttgc ctgcgcgatg tttttatcag cctcggcctg atcggtttgt aaaattgccc 2141641 cgatgttttt gccgatatct acatctgcaa tatcaattga gagaatttca aacgcagttc 2141701 ctgagtccaa tccttttcca aggactgtct gagaaatcat gtcagggttt tcaagcactt 2141761 ttttatgatt atcagatgaa ccgattgtag aaacgattcc ctcacctaca cgagctacaa 2141821 tggtttcttc ccctgctccc ccgacgaggc gctcgatatt cgctcttact gtgattctcg 2141881 ctttcgcttt cacttcaatc ccgtccattg cgacgccggc aatgaacggt gtttcaatca 2141941 ccttaggatt aacgctcatt tgaacagctt ccaacacgtc ccggcctgca agatcaatgg 2142001 cagcacagcg ctcgaatgtg agttcaatgt tagctcgctg agcggcgata agcgcgttga 2142061 cgactctgtc aacattacct ccagccagat agtggctttc aagctggttt gttccaacat 2142121 taagtcccgc tttatgcgct ttaatcagcg ggttaacaac ccgattcgga atgacgcggc 2142181 gaagcctcat cccaactaga gtgaaaatgc tgattttcac tccggctgcc aaagctgaaa 2142241 tccaaagcat tacaggcaca aatgtaaaaa atactgccaa aacaatgatc gctactgcga 2142301 caattgccag aatcataagt gttgacggat ccatataact tctcctcgtt tctatttaaa 2142361 tttctctcac gacaatgcgt gagccttcta cttttatcac ttttactttt ttatcttttt 2142421 ctgtaaacga tccctccgat acaacgtcaa ggcgttcatc atcaataatc acggtaccgg 2142481 aaggacgcag cggtgtaaag gttataccca cttttcccat taagtccgtg cgcgtttgat 2142541 ttgaaacgta gccgctctcc gtgtttgtag aatcatttaa tatcaatttc ttaaagaatt 2142601 tcatacgctt tcccaacacc cttgtcagta aaataaaagc tgtaatcgaa acagctgagg 2142661 cgatcaagag agaaaccgcc atgacagtga agctccccgc ggctaaaaac aggctcgcaa 2142721 taatcgctcc caagcccagt aatccaatga ttcctccggg aagaaaaatc tcaagcagaa 2142781 tgagaatcac ccctgctata aagaggagaa ccgtctcata cccggcaagg ccggctgcaa 2142841 gatgcccgta aaagaacagc aataacgcaa tgagtccagc cgttccaggg aggccgacac 2142901 ccggggaaaa aagctctacc gtcagaccta aaaaagcgat tgtcagcaga atagggacaa 2142961 tgaccggatt cgtcagccat cttgccgtct tttccgcaaa gctctccttt gcatagctga 2143021 tctgcgcctt ttcgaaccca agcttcttta cgagcgtgga caaattgtca gcagtgcctt 2143081 ctgaatagcc tacctcaatc gccttgtctg cgttaagtgt cagcagatct cccttaggcg 2143141 cgccaacttc cttggcatct atatctgggt cagccattgc gagcgcatat tttggatcgc 2143201 ggttattttt cactgcggca tcttccatct ctgccagcca aagtgattga gctttttggt 2143261 cagcggcatt gccttggcca tcaacaatcg cggcggctcc catttttccg ccaggcgcca 2143321 tataaatgtg atctgcttga agtgcaatat atgcaccagc agacaacgcg cgtttgttga 2143381 catatgcagt tacggggatc tcgctttcgg ttatcaaatc ggccatatca atagcagatt 2143441 tgaccaatcc ccccggggta ttgatatcaa gaataatatg gtctgcatgt gcatcctttg 2143501 cgtcttgtaa cgaacgggac aaaaacgagg cgagaccctg ttcgacattt ttttcaaccg 2143561 ggatcacata aacagtttgt ttttctgctt ttgcgttcag ctgtacgcct aataaagaaa 2143621 gtaaaaatat acccaaaaga gcagcacgga atcctttgat ttgaagcaag ggcggtgtat 2143681 ccctccttcc ttttataata agtgccttct cttcatacgt aacaaatgta tcaaaggttt 2143741 cattttttta tgtataaaaa aagacatctc tcttagaaag atgtcctttt ctttgccatt 2143801 taagacagtt gactgctcac aagcttatta attaaacttc cgtcagcttt accttttact 2143861 ttaggcataa ttgcccccat cactttgccc atgtccgctt ttgagctcgc accgacctcc 2143921 gcgatggttt catttacgat tgtacgcagc tcttcttctg acagctgctc aggtaaataa 2143981 acttctaaaa tgtccagctc tttttgaact ttatctacta aatctaaacg attagcgttt 2144041 gaaaattcct ggagggagtc tttacgttgc ttaagttcac gagaaaggac agtgagttcc 2144101 tcatcctcgg tcaaactgtc tttcttaagc ttaattgctt cattttgaag tgaagcctta 2144161 accattcgaa cgacagtcag tttgtctttc tcacggtttt tcatatacag cttcatatcc 2144221 tggttgagac gctcaagaag actcataaat ccaccctctt ttagaatttg cgttttctag 2144281 cagcttcaga ctttttcttg cgctttacgc taggtttttc ataaaattca cgctttcttg 2144341 cttcttgcaa agtacctgtc tttgatacac tgcgtttgaa gcgacgaaga gcatcttcaa 2144401 gcgattcgtt ttttctaacg accgtttttg acattctctt tccctccctc cgaatacacc 2144461 aatcgactac ctttaagtta cacatataaa catgtacttt gacattataa tataagccat 2144521 cagtcaggtc aactaagtga gttcactttt ccgtcatgag tgcgactgcc tgtctatata 2144581 atgaaagaaa ggggttggtg aataggatgt taattctgat tagctttact gctcttatat 2144641 tattctttct cgcaggcatg aacatgcttc gaaagggctt aatttcaatg gcgtactcaa 2144701 aaattgaaga acgtttgctt ttatttacag accatccgtt aaaagcgttt cttatcagta 2144761 ttgtatttac ggggatactt cagagcagct cagcctttat ggtcattgtc atcggctttg 2144821 taagtgcggg cgttctttct tttaagcgga cgatcccgat gattctgggg acaaatgttg 2144881 gctctacttt tacaactgaa tttattgcta tcaaaatgga tattgtgatt tgggttcttt 2144941 taataggagg tttattgttt tttctgactg gcaggtatcc tttgaaacag ctgggaacaa 2145001 gcttccttgg actgggcatc atcttctttt gcatcagcgg attcagccat cttgccgggc 2145061 cgctgacaaa gctgaaaacg ggcgccgacg ttctatacca tgttaacgat tcaaactggt 2145121 ccgctttgct catcggcatg gtgttaactg ccatcattca ctccagttct gtctgtatcg 2145181 gcattttgat gagttttatg aatgaaggga ttatcggact gacacaggcg atgagcgtcg 2145241 tactcggatc aaatatcggg acatgcatta cagctgtcat ggctgctgta tccggcggat 2145301 atgcggcgaa acagacagca tatgcccatg tggtatttaa cgtgctaggg gtggctctag 2145361 tattgccttt tctgaccgca gcgaccggct ttgtagagca gttatcacct gatcccgcac 2145421 aaaagatcgc gcatttcagc cttttattta atgtggtgac agctctttta tttcttccgc 2145481 ttacaaactt gttttaccga ttgattcacc ttcttatccc ggctaaataa aaaaatcggt 2145541 acattttaat gcaccgattt tttaggttaa gaagacaaac gcatgtgttc agttatttca 2145601 tcctcaacca cacggacaaa ctgtccttcg ttgtaaggat aacctgcttt taggattttg 2145661 acttttacga ttttgccgat catatcttcc gtacctttga aaacaacctt catataattg 2145721 tctgtgtaac cgacaaacat attttcttct tctgtttcct taaacgcttc ctcagggata 2145781 atctcaagca cttcattttc atactgagaa gcgtattctt ttgcaagctg gtcagaaaga 2145841 gcaatcaggc ggtgcacacg ttcgtttttc acgttttcat ccacttggtc ttccattcgt 2145901 gcagctggtg ttcctgtacg cttactgtaa gggaaaacat gcagctcaga gaatttatgt 2145961 tctttaataa agttataggt ttccataaat tcttcttctg tttctccagg gaacccgacg 2146021 atgacatcag aagtaacagc taagcctggc agtgcttttt tcaatttatt taaacggtct 2146081 gcaaagaatt ccattgtata tttgcgtctc atccgtttaa gcactgtgtt tgatccggat 2146141 tggataggaa tatgcaaatg attcactatc ttatctgagc ggtctaagac ctcgatcact 2146201 tcgtcagtga tttggctggc ttcgattgaa gaaattctga tccgtttcac gccttccaca 2146261 cgggtgtcta attcgctcaa aagcttcgcg aagttgtaat ctttcatatc ttcgccgtag 2146321 ccgcctgtat gaatacccgt aagaacaatt tccttatatc cggcatcgac aagctgctgc 2146381 gcttgtttaa tgacttcttc agggtcgcgg gagcggagca ggcctctcgc ccacggaatg 2146441 atacagaatg tgcagaaatt attgcagccc tcctgtattt tcaatgacgc tcttgtgcgg 2146501 tccgtgaaag caggcacatc aagctcttca tatactcttg ctttcatgat gttgctgacg 2146561 ccattaatcg gctggcgttc ttctcggtat tggtcaatgt agccaagcat tttttcacgg 2146621 tcctgtgttc cgactacaat gtcgacaccg gggatcgcca taatctcagc aggtgaggtt 2146681 tgcgcgtagc agcctgtgac acagatgaca ccgtcaggat tttgacgaat ggcgcgtctg 2146741 atcacttggc ggcttttttt atctcccgta tttgtaaccg tacatgtatt aatgacatat 2146801 acatcagctg tttgttcaaa gtctcttctt tcatagcccg cttctttgaa aagctgccag 2146861 attgcttctg tttcataatg gttgacttta cagccaagcg tatggaaagc aacagttgcc 2146921 attactgatc acctcttaat aactctgttt gataagaaat cgcactcaac gcgtatagcg 2146981 gagcggtttc tgtccttaaa attctcggtc caaggccgca cgtcacaccg tcttgctctg 2147041 tgagccgttc aacctccgct tctgttaaac cgccttcggg accaaatacg atcaatagag 2147101 atgatccttt cggaaggctg cttacaatcg cgctgaatgc gcttatttcc ccttgcttcg 2147161 atgactcctc gtatgcaacg acacatttat cgaaatcctg catcctttga agaagctgct 2147221 gaaaagaatg gacatccatc actcgcggca cttcgttacg gtacgattgc tcagccgctt 2147281 ccttcgcaat tttcgtccat ctttcccgct ttttctttgc ctttttgtca tccagcttga 2147341 caacagaacg cgcggcttgg aaaggaataa aggcatgagc tccgagctca gtcccctttt 2147401 ggataatcca ttcaagctta tctcctttcg gaaggccgct cgcaatatag acctttatcg 2147461 gaagctctct gttttcattc gtccattcta tcacaaggca ggacacttta tctttggaaa 2147521 cagattgaag ttcacatttt gcctcgaagc cgtcttgaga gcagcagata atctgatctc 2147581 cctcattcat tctcatcacg ttcacaatat gatgaacttc ttcgccggta atcgaaaaag 2147641 tcggcgcttc ctctatttgc tgcttcgtga gctcgataaa atatcgttgc atacgctgtg 2147701 acacctacta actgttattt tttcgcaata atgctgaccc aatcttccat tgaaaggatt 2147761 tctacaatgg taaagccagc ttgttccagt gcttctttta cttcttgttt tttatgaccg 2147821 atgattcctg acgtaataaa gtgaccgcct tcttttaaca ggctgtacgc ttgtgaagta 2147881 aagcgaagaa tgacttcagc caaaatgttg gccacaatca catcatgttc cccttcaatc 2147941 ccgtctaaca aattgttttg cttcacttga gcaatatcgc tgactttgtt cagcttgaga 2148001 ttgaggcgtg cactttctac agccacggga tcaagatcgt aggcatgaac cgattcagcc 2148061 tcaagcattg cagccgcaat acttaaaatt cccgaaccag tgccgacatc aatcacctta 2148121 tcaccctttt gcacaaagcg ttcaagcgcc tgaatgcaga gtacggttgt cggatgtgtc 2148181 cctgtgccga aagccattcc cgggtccatt tcaataatca gttcatcagt atggaccggc 2148241 gtatattcct cccacgtcgg cacaattgta aacttttcag aaattttcac aggatgataa 2148301 tactttttcc aggcagtcgc ccactcttct tcatttactt cagaaatagt gatgtggttt 2148361 ctgcccaaat caatattgta aagaaggaga ttattaatcg tttctttgat gccgtctaca 2148421 gtttcgccca gaaaactgtt aaccggcaga tatgctttga caatgacacc ctcatctggg 2148481 taatcattgg ggtcgagctg gtagatttcc ccgtacacat tctcacgttc tttaattaaa 2148541 tcaagcgggt cctctatcac aaccccactt gcaccagctt catgcaatat atttgagata 2148601 ggttcgaccg cttcatgtgt tgtgtgaatg cttaattcgg accatttcaa aactaccaac 2148661 tcctcatcca ataattaatc gcctttaaac gcgcgtttta ccttgtcaaa gaaactcatt 2148721 tcctgttcgt caggcaggtt tccgctgact tcggcaaatt cgcggataat gtctttttgt 2148781 ttatcagtca gatttgtcgg cgtaacgacg cggacgacga tatgctggtc accctgtcca 2148841 tagcctctga cattttgaac gcctttgcct cttaatctga atttcgttcc tgtttgtgta 2148901 ccggccggaa ttttcaattt cacttttcca tgcagcgtcg gcacttctac ctcatctcca 2148961 agagcagcct gagcaaacgt taacggcatt tcacagtaaa tatcatcgcc gtcacgctcg 2149021 aagaactcgt gtgcgcgtac atggaacacg acaaataaat ccccggcagg gccgccgttt 2149081 attcctggtt caccctgtcc cgagagacga agctgctgcc cgtcatctac accggctgga 2149141 attgtcacat tgattttctt gcgttttttg atttttcctt tgccgccgca gtccgcacat 2149201 ttgtttttaa tgattttgcc tgtaccttca cagtggtggc agacccgtct gttaacgact 2149261 tttccaaacg gtgtattttg ctccacgttt aactggccgg agcctccgca gtgggagcat 2149321 gtttctggat ttgttccagg tttcgcacct gagcctttac atgtttcgca cgtttcctcg 2149381 cggggaattt cgatggttgt ttctttaccg aaagccgcat cctcaaacga cagggtcatc 2149441 gtatactgta aatcagcacc ctggcgcgga gcgtttggat ctcttcgtct tgtgcctccg 2149501 ccgaatatac ttgagaaaat atcatcgaaa ccaaaaccgc cgaaatcgcc gccgccaaaa 2149561 cctccgccgc cgaagccttg gttagggtca gtgtgaccaa attgatcgta atgcgcacgt 2149621 ttttggtcat ctgacagcgt ttcgtatgct tcttttacct ctttaaattt ttcatctgat 2149681 ccggcttctt tgttaatatc aggatgatat ttttttgaca gcttccgata agctttttta 2149741 atttcatcct ttgaagcgct cttacttact cccagcactt catagtaatc acgcttactc 2149801 atctcgcttc actctcccga atttctcaca taaattagat tgtatcattt tgaattatga 2149861 tttttcaatt ccttttatcc cgggcaagaa aaaaagtcaa agccaagaga tgcctgactt 2149921 tgactttcta atcattgaat cagattatga aatgtgttct tttcggtcag ctccggaagc 2149981 ggggctgaca ctaaaaagaa cttatttttt gttttggtcg tcgtttactt cttcgtattc 2150041 agcgtcgaca acgttgtcat ccgctttgcc ttcagcgttt gctccgcctt gagcttgctg 2150101 tgctttagca gcttcttcat aaagcttcat agaaagctct tgaacgattg tttgaagctc 2150161 atcttttttc gctttgatct cttcaaattc gtttttctca atcgctgctt ttaaagcgtc 2150221 tttggcatcg ttggcttttt tcacttgttc ttcgtccact ttgccttcaa gatcttttaa 2150281 tgttttctca gtttggaaaa caagctgatc tgcttcgttg cggacttcga tttcttcttt 2150341 tttcttcgca tcagcgtcag cattttcttc cgcttctttt accatgcgtt cgatctcttc 2150401 atctgagaga cctgaagaag atttgattgt aatgttttgt tcttttcctg tgcctaagtc 2150461 ttttgctctt acgtttacga taccgttttt gtcaatatcg aaagaaactt cgatttgagg 2150521 cacgccgcgc ggtgctggcg ggatatcagt aagctggaag cggccgagtg ttttgttgtc 2150581 ggcagacatt gggcgctcac cttgaagaac atggatatca acagctgttt ggttatcagc 2150641 agcagttgag aacacttgag atttgcttgt tgggatcgtc gtgttgcggt cgatcagttt 2150701 tgtaaacaca ccgcccattg tttcgatacc gagagaaagc ggtgtaacgt caagaagaac 2150761 aacatctttt acgtcacctg tgataacgcc gccctgaatc gcagcaccaa gcgctacaac 2150821 ttcatccggg tttacgcctt tatgcgcttc ttttccagtt tcttttttga ttgcttcttg 2150881 tacggcaggg atacgagttg atccgccgac aaggatgact ttgtcgattt cgcttgcaga 2150941 aagtcctgca tcttgaagcg cttgacggac aggacccatt gtgcgctcta ctaaatgaga 2151001 agaaagctct tcgaatttag cgcgagttaa tgtaagttca aggtgaagcg gtcctgcttc 2151061 tccagctgtg ataaacggta aagaaatttg cgtagaagat acgccggaaa gatctttttt 2151121 cgctttttca gctgcgtctt tcaaacgctg aagcgccatt ttgtcttttg acaaatcaat 2151181 gccgttttct tttttgaatt cagacaccag atgatcgatg ataacttggt caaaatcgtc 2151241 cccacccaga cggttgtcgc cggcagttga acgaacttcg aatacaccgt cgccaagctc 2151301 aaggatggaa acgtcgaatg taccgccgcc aaggtcgtat actaggatcg tttgatcttc 2151361 atctgtttta tcaagtccgt atgcaagcgc tgctgcagtc ggctcgttga tgatacgttc 2151421 tacttcaaga cctgcaattt taccagcgtc ttttgttgct tgacgctcag catcgttaaa 2151481 gtatgcagga actgtgataa ctgcttttga tactgtttcg ccaagatagc tttcagcgta 2151541 tgatttaagg tgttgaagga tgatagcaga cacttcttgt ggagtgtaat cctttccttc 2151601 aatttcaact ttataatcag tacccatatg acgtttgata gacataattg tgttagggtt 2151661 tgtaatagat tggcgtttag ccacttcccc tacttgacgt tcgccgtttt taaatgcaac 2151721 aactgatggc gttgtgcggt ttccttcagc gttagcaata actttaggct cgccgccttc 2151781 aagcactgcc acacatgagt ttgttgttcc taagtcgatt ccgataactt tactcacttg 2151841 aataacctcc tgctatgtaa ttattgattc actttgacca tggaagggcg aatgacgcga 2151901 tccttcagct tatagccttt ttgcatttcc tcaacaacaa tgttggagcc gtagttttcg 2151961 tcttcagcct gcataacagc ttggtgcaga ttaggatcaa attcctgccc tacagcttcg 2152021 atggcttcga cgccttcttt tttcaaggct tctacgagct gacggtggac catttccatt 2152081 ccctggagca aacttttcgt ctgttcattg tcggcttcaa cctgaagcgc tcgttcaaaa 2152141 ctgtcaagag ccggcagcaa atcagtcacg atattttgag aacggtattt ttgggacgct 2152201 tccatctcta aacggctgcg tcgtttatag ttttcaaagt ctgcttgaac acgcaaaagt 2152261 ttgttttctt tttcctcaag caaaccttgc aattcgttaa tttggttttg aagaagttcg 2152321 ctttcatttg tttcttcctg ctgttcatca gcggcagctt gttcttcaat gatttcttgc 2152381 tcttctgttt cgttttgttc aacggtttgt ttttcttctg acattgtgtt cacctccctc 2152441 aaagtgtaag gagaaggaca ggtgctgccc ttcgataaaa tttgccaaaa ttcccttatt 2152501 catcatacag acttgttaat gcttttgaca agtccgaagt cacatgctga agcaggctga 2152561 caaccctgga ataattcatg cgggtcgggc cgataatcgc aattgagccg atctgcttct 2152621 ggtctacgga ataagaagcc gtaatcagac tgcaattttc catctcttca tagtcgtttt 2152681 cttttccgat tttaatcgaa attcccgtgt gcggggattg aaccagcttt aaaacatcct 2152741 gttctttctc aattaatgaa agcagcgacc gaactcgggt gatatcatgg aactcaggct 2152801 ggttcagcat attgattttc ccgccaaaaa acaacttttc aacgtgattt gtggaatgaa 2152861 aggttgaacg aagcgcgtcg agtatattgt catagttttt aatgtgctgt cttaggtaca 2152921 tgacaacttc tttaaatatg cgctcattca gttcatccat tggaacgccg cttaaacggt 2152981 cgttcagtat atttaccagt ttttcaatat cagacagatc cattttggtc ggaaagttaa 2153041 tcgttttgtt ttccacatgc cccgtattgg taacgagaat cgctaccgcc atatcaggct 2153101 gaatcggaat gatttgaatc tgtttaaggt aattctcact caacttcggc ccgagtacga 2153161 tggatgtgta attcgtcaga tcggacaaaa tttgcgctga tttttgaact gtcttctcca 2153221 gctcgaaaat tttctctttg aagatcgagt ggatttggtc caggtcgctt ttcgtcaatt 2153281 tgacgggtga cagcaaatgg tcaacatagt accgataccc tttttctgac ggaacacgtc 2153341 ctgaggatga atgggttttt tcaataaagc ccaattcctc caagtcagcc atctcgtttc 2153401 ttattgttgc agagctaaat gtgatttcat cttttttcga aagagttctt gatcccaccg 2153461 gctgtgccga tttaataaaa tcgttgatta taacctgaag gatcagcagc tgacgatttg 2153521 ttaacatcat catcacctct gttagcactc tcaataagcg agtgctaatt ctataacaaa 2153581 agtatcaaac cacaagaaaa atgtcaatta taactcaccc aaaaaagcgc caaaaacttc 2153641 attgcctaat aatttccctt gatgagtcaa ataaacggca gactccgaat tgtgaatcag 2153701 ccctttttca gcgaggtctt ttaacacgct tgggaaaagt ccatccaggg aacggccgta 2153761 tttttctgcg aatcgttttt tgctgacacc ggctgttttt ctcaaaccta aaaacatttc 2153821 ttcctcaatc tgttcttctg ttgtcacttc atgtgtatct ctgtacggaa aacccttttc 2153881 agctatcagg tcaatgtaat gcttaacagg tccgacgttc actgttcgtg tgccgccaat 2153941 atatccgtga gcgccagctc cgaaaccgaa atattgttcg ttgctccaat acgttagatt 2154001 gtgcttagat tccatgcctg ccttagcaaa gttgctgatt tcatattgat gaatgccgtg 2154061 agcttccatc ttgctcatca ctatttcata catttcagct tcctgctcct gcggcggaag 2154121 atgaagccgc cctttttgca tcaaattata aaataccgtt ttcggttcta caataaggga 2154181 gtaaacggaa taatgctcag cgtccaatga taaagcagtg tttatggaat gttccagatg 2154241 cttgagggtt tgccccggaa gcccgaacat gagatcaaga ctgatattct caaaaccgat 2154301 ttcccgcgct ctttcaaaag aggtgaatac atctttttgc ttgtgcactc ggccgatttt 2154361 ttctaacaga tcgtcttcga acgtttgcac accaaagcta aggcgattta cgcctgcttc 2154421 ttttaatatt tttaatttct ctgcggacaa atcgtccgga ttcgcttcaa ccgcaaattc 2154481 cgataagtcg cttgagggct ttagcacgcg gttgatcata tccatcagct ttttaagctg 2154541 ttcctcagac agggaggtcg gcgtgcctcc tccgataaag attgttttga gatcaggctg 2154601 cccggttttt gctattgtat ttatcatttc ctgttcgagt gcgtttaaat actcgtcgac 2154661 tggctgactt tgaataaaat atttattgaa atcgcagtag tggcaaatat gctcacaaaa 2154721 tgggatatgg atataagctg atttcaacgg attcaccttc tttacagaaa gaagccgcag 2154781 tacaagactg cggcggcttc tattgttttt tcggactgtc gtccattttc agaactgcca 2154841 taaatgcttc ttgcggcact tcaactgagc cgacctgctt catacggcgc tttccttctt 2154901 tttgtttttc aagaagtttc cgtttacgcg agatgtcccc tccgtaacat ttagccaata 2154961 cgtttttacg cattgctttt atggtggagc gggccacgat tttctggccg attgcggctt 2155021 gtaccggaac ttcaaactgc tggcgcggaa tgagttcttt cagtttttca acgatcactt 2155081 ttccccgttc atatgcgtaa tcacgatgca cgataaagga aagggcatcg attttttcac 2155141 cattcagcat aatgtccatt ttcacaagct tggacggttt gtagccgatc agttcataat 2155201 caaaggacgc atagccttta gtgcttgatt tcagctgatc aaaaaactca tatacgattt 2155261 ccgctaatgg catatcataa atgatgctga cacggtttgc gtctaaatac tgcatatcaa 2155321 tgaaattgcc gcgttttcct tggcaaagct ccattacagc gccgacatag tcattcggca 2155381 ccatcatcgt cgcttttacg tatggctcct caaccctttc gatcttttga ggatccggca 2155441 tgttggacgg gttgtcgaca acgacctttt cgccgtctgt catatacacg tcatagataa 2155501 cgcttggcgc tgtcgtaatc aggtcgatgt tgaactcacg ctcaattcgc tcctgaatga 2155561 tctccatgtg aagcatgcct aaaaatccgc agcggaaccc gaatccaagc gcttgcgaag 2155621 tttccgcttc atattgaagg gaggaatcat tcagctcaag cttttcaaga gcttccctta 2155681 aatcattata cttcgctgta tcaatcggat acaaaccaca gtacaccatc gggtttagct 2155741 tgcggtatcc cggcagcgct tcttctgcag gattggcagc gctcgttatt gtatcaccga 2155801 cacgtgtgtc accaacattt ttgattgagg cagtcaggaa gcctacatca ccgaccgtca 2155861 gttcatttgt cggagttgct ttcggcgtga acacgcccac ctctgttact tcgaattctt 2155921 tgccggttgc catcattttg attttttgtc ccggctttac cgttccttca acgactctga 2155981 tataagccac gacaccgcgg taggcgtcat aaagcgagtc gaagatcagc gctttgagcg 2156041 gcgcctccgg atctccggtc ggagctggca ccttttctac gatttgttct aaaatctcct 2156101 caatcccgat accggctttt gctgaagcaa gcacggcttc tgatgcgtca aggccgataa 2156161 cgtcttctac ctcttggcgc acacgttcgg gctcggcgct cggaaggtcg attttattga 2156221 tgaccggaag gatttcaaga tcgttgtcaa gcgctaagta gacattggcg agcgtctgcg 2156281 cttcaatccc ctgggctgca tccacgacaa gaatcgctcc ctcgcaggca gcaaggcttc 2156341 gggatacttc atacgtgaag tcgacgtgtc ccggcgtatc gattagatga aagatatatt 2156401 cttctccgtc ttttgcttta tatttaagct gaacagagtt taatttaatg gttatgcccc 2156461 gctcacgttc aagatccata gaatcgagca attgttcttt catttctcgt tgagtgattg 2156521 ccgacgtttt ttctaaaata cgatccgcta aggtcgattt tccgtggtca atatgggcaa 2156581 tgatagagaa attccgtatt ctcgattgcc tctctaaacg cttttcttta tctgtcacaa 2156641 tctatcactc ctactattaa acgcaaaata cactagctta gattatatca ataggattgt 2156701 aaagattcaa tgtaaaacaa gaaagagaaa agttccctat catatctggg ttgcttttct 2156761 ctttcacgta cttattgatt catatcccgt atccattcat acattgactg ggcagtattg 2156821 gttacggtgt ccgaaagcgc ttttccggct tttgaaaaca tattgaatgt ctccaccttt 2156881 tccagctctt tttgtttttc tactaaatct tttgccgtga ctgtttctcc taggattgag 2156941 gcttcttttt cattatcttt tccgtcggtg agcgtaaacg cccccttcag tgaagggtca 2157001 tgatagcctt tcatactcag catcccgtgg tttgcctgct gcatgccgaa cagaacgcct 2157061 aaaaacatga tcgtgacaag cagtaagcac tttccaaagt atgcaatcaa atcaaccacc 2157121 tatttcttat tgttttttcg tctccccgct cgctgcgttg accttttcag catcccagta 2157181 catttcgctg aatacgtccg cggccgcgtt agccgcacgc tgcagctctt cgagattatt 2157241 atccactccg ccaaactcga gcaaaagcgc tctatcggtt aaatcctgat tgtaaacacc 2157301 attatcgcct ggcgagcctt tggaaaagac acctgtgcta agtccggggt attttttctc 2157361 catcagttta tgaagctcac tcgcaatttt atagttttct tcgaagtttt tgcttttttt 2157421 cccgacgaca aaggctaccc tggcatagct tttcccttta atcgttgcgg ttgtgtcttt 2157481 tttgcgccga gagtctctgt ggatgtcaat gatatattgc agatttttgt ttgaagcgag 2157541 ggcgtctttc acgaccggcc ttgattcatc ataggacctg gcatagttta agcctttttt 2157601 attcaatttt gactgtatat cggttttatt cactgtggct ccgattccct gggattcaag 2157661 cgcttgtccg aacatatctc ctacaagcgt gacattggct ttagaatggc gcgccatgtc 2157721 aggatcggtc tcgcctttta atagagggag atatgattcc gtattgtgcg tgtgatagat 2157781 aaacacgacc tttttatcac ctgttgtttg tttcggcgga tctttttgcg cattatctga 2157841 ttgcgtttgc tgtttttcaa tctctgccaa attcgcttct ctttcttcct ccatcacctt 2157901 agacggcggc ggcgattccg caggcatatt cgtataatcc gttccttgtc cagctaacaa 2157961 aatctcggta tcaaattgtg caaatcctgg cagctcccga ccgagaaagc tccgcggatc 2158021 ttcgaggtta atgctcgtcg ccagctttaa agaaagacga gaaagatgaa atgagctgtc 2158081 tgtttgagag aggtcagaag cgaaataatg gttttccatc tgcagcaaat gtgcaaatac 2158141 gtcacccggc aattcttcag caatcccata aaaagagtca gacgacggcc taagttccgg 2158201 ccggagagac gtcagcacac cggatagaac aaaaatcacg ataaggctta cgataaatag 2158261 aaagatggct tttaccgctt tccctccatt taccgcaaca acaatctgtc tgtttctgcg 2158321 tttatttctc attgaatccc tccagcgctt gtctagtaat tactctatga acaagctaga 2158381 ggaagtagaa ctgtttagtg attgtaggag cctttgtttt cttgtgacac tttttcatga 2158441 agcgctgtgt ttaatccgtt cgctaaaaca tttgccatat cgtcgataaa tgaatcgact 2158501 tccttcggtg taaccattaa gttgtgccct aaaggcgaaa gcacctcgtg aatgagctgc 2158561 cgtttttcat cttcttgaag ggttccgaca atacctagga acgattggcg ctgcttttga 2158621 tcgggaagat cgtcttcagt gagcactttc tttttcccaa acgtcatgcc tgccggaaca 2158681 agcgatcttg atggcctgtt atccttcatt tctctgccaa aatgttttaa tatgtagtcc 2158741 accgtgtcgc tggcaattgt cacggcatca actactgtcg gaacaccgat agcaatcacc 2158801 ggaacaccaa gcgtgtcttt gcttaaatct tttcgtttat tccccactcc agaccccggg 2158861 tgaatgcctg tatccgatat ttgaatggtt gtgttgaccc tttccaccgc ccgcgccgcc 2158921 aacgcatcaa tggcgatgac aaaatcaggc ttcgattgct caatcacacc tttaataatg 2158981 tcacttgttt cgattcctgt tatccccatt acacccggtg caaaagcact gacaggcctg 2159041 taaccctcct gtacgttttc cggctgaagc ttaaacaagt gccttgttac caacagattt 2159101 tctactgcca tcggtccaag cgcatcaggt gtcacgttcc agttgccgag cccaacgatc 2159161 aaacagctcg catcttttga gatattaagg ttttcaagaa aagctgagaa ttcctccgca 2159221 aagacagcag agaccttctc ctgcatttcc gaatcattct ccctgattcc ctgtgcttca 2159281 agcgttaaat agcgcccttc tttttttccc gaaagctctg cgccttcctt tgtaacatca 2159341 actgtgcgga ttttaatgcc gccgtgatca cgctcttttt caataaagcc tttaatttct 2159401 tttgtcggca cagcctgctg attggccatt gcttccttcg tttccactgc caaatcggtc 2159461 cgtatcaaat actgattcac atccagctca ctctttttca tacaggggcc tccttcacat 2159521 taagtaccta tattgttgcc atttgctgaa taaatcatgc taaaaagaga accttcaatg 2159581 aaaaatactt tacatttata ttgcaatcta aaggtgtgtt tgatagaata caatttgttc 2159641 tattgtgaag aagatttaac cttaagacac tgtgctacag gttgtatctt aggaggtgaa 2159701 acacatgcca aacattaaat cagcgattaa acgtacaaaa acaaacaacg aacgccgcgt 2159761 tcataacgcg acaatcaaat ctgctatgcg tactgcaatc aaacaagttg aagcttctgt 2159821 tgccaacaac gaagctgaca aagcgaaaac tgctcttact gaagcagcta aacgtattga 2159881 taaagcagtg aaaacaggtc ttgtacacaa aaataccgca gctcgataca aatcaagact 2159941 agcgaaaaaa gtgaacggac tttctgcata atataaaaac gatcctcaat aatggggatc 2160001 gtttttttca tttcttttta acagctgtaa aaggaacagt tcgagcagga gctgcttgtc 2160061 ctttttcccg gttttcatct catagtccat gacggcaagc tgttcaataa ttaaacggag 2160121 ctcctcctct gaaaaaagcc ttgcttgatc catcgccagc tttacccgaa atgggtgaac 2160181 ttttagatta gaagcgattt gtttttgtcc gtatccctgt tccgcgaagt acttcgtctg 2160241 cagaatcagc cggaactgat tcgaaataag cgccataatt ttgatcggtt cttcattttg 2160301 ttttagcaaa tcataaaaaa tttgcagact ctctgttcgt tttcggttga cgattttatt 2160361 gatcagctca aaaatatttt gttcaaggct tctagcaaca agcattttta catcatccag 2160421 cgtaatttct tcacgatctc caataaacgt gcagagcttt tgaatctcct gaaaaatcga 2160481 tgacagatga ccgttcacaa gcagaaccaa atgctccgcc gcttccgtgc cgattgtttt 2160541 ctgctctgtt tttgcaaggt tgacagtaaa gtctgtcgtt tcctttgcat ttaattcctt 2160601 cgcctccatc ataaacgcgt gcttctttaa cgctttcgtc agcttttttc gctcatcaag 2160661 cttttcatac ggagcaagca ggacaaagac tgtgtaaggc gcaggtgatt gtatatatga 2160721 ttcaagcgca ctgacgttgt gctcaatttt ttcttttttc ttttcacctg ttaaaaaata 2160781 tggatttttc acaatgacaa gacgccgctc ccccataaac ggaaacgttt cagcatctgc 2160841 aatcgcttga tccagcgggt cctcttccag atcaaaaacg gacagattga aatcctttgt 2160901 ctcctgatca acgaccgtct gtctgatcct gctgacggtt tcttgcagca gatatgtctc 2160961 ttttccgtat aaacaataaa ccggatggac ctctcctttt ttcaggcttt tccacacatc 2161021 aaataccatt gttgtacgac ttcctctctt tcatcatccc cttctatcct aaattgagtt 2161081 tgcaaaatag taaagaggaa gcctgactgc tgcttcccca tttatattaa acgcctgttc 2161141 gcaagccccc gggacagctt gtaaaaaggc gataatcacc agaacagaaa acgttacctt 2161201 agcttctaga tttttcaaaa caattccatt atacttaagt cagtcaggag ggataaagtt 2161261 gaatgatttt gaaaaaaacg ttcaaagcaa acgaaatgat gctgtagatt cagctgttgg 2161321 ttttgttgtg tccttcggat ttttcgcctt cttgtttgtc atggcaacgg ttattcacct 2161381 agttggttca taacagcgac tgcccgggct gctgatttct cggcagtctt ttttagttcg 2161441 tctctgttat atctgatgta tcatatggag gatagacaga aaaggttcca actctgtttt 2161501 tgtatctata ttggatcgtt ccgttttgat ctgttcgcag cacgcggata gaatgtctct 2161561 gtaatagttg cagaactttt tgatgaggat gatggtaccg attgtttttc ccggctgaga 2161621 taatggccgt tttcggctga agctgttgga tgaattcttc accggtagag cctttgctcc 2161681 catggtgccc cacctttaac acatctgctt ttatattcgg aaacacgttc atcacctctt 2161741 gttccccttc tttctccaga tcacccgtca agatccagct cataccgccc gtctccatcc 2161801 acagaacgag agatgaatta tttttgcttg ccggatcagg tgcttccggt gacagtacat 2161861 ggaactgcaa atcctttatt tgcaacacat cgcctcgctt cacctcttca attgccactc 2161921 cctcttccct ggctgcctgc agcactttct catctttagg ttcagaaacg aaccctttcg 2161981 gaatcacgag gcgctttact ttatgatgct tcagcagaat ctccgcctct ccgatatgat 2162041 cttggtcagc gtgcgtcaga attaaagcgt caagctgctt gattccctta gcagttaaaa 2162101 acggaatcag caccttttcc cccagtgaaa acggatgctg tttttcgcgc caaggctctg 2162161 acgagtaaga caaagtgccg ccggtatcaa ttaagacacg accccgctga tgcggagcac 2162221 ctacaaacat gctgtcaccc tgtccaatat ctatcatatc cacttctcct tcggaactaa 2162281 gacacggata tataaagagc agaaacatca ccgtgcagca aatgcctccg gttaccatca 2162341 actgcgacaa ggagcgtttt tcaatcgcca taagcaatag gatgatcgtg actgtgaata 2162401 aaaaaagcaa aacaggtgca ggatgtgcga tcataatcgt gaacacatca acatctgcaa 2162461 tgtttgtgat taacctattg atccagctta tcaataaatc aaaccagctg aaaaacaatc 2162521 tcccaaacga agcggaaaga cttaatagaa gaacacctgc tacagctccc ggcaaaatac 2162581 agaaggtata aaatggtacc atcaacatat tcatcggtac gctgatgata gaaaactgat 2162641 gaaaatgata taggagaatc ggaagcgagc ccagctgagc gatgagtgat acaattgtca 2162701 gctgccccaa ggaggtttta acctgctgaa aaatagaaga ggatagaatt aaagaaaaac 2162761 tgacggcgaa cgatagctga aaaccggctt caaagagatg ataaggattg aagagcagaa 2162821 ggacgatgta cgaaaggcaa attgcagttg cagagcggac acgccatttg acaagacttc 2162881 cagctaagta aacacccgac atgagagcgg cgcgtagcac tgaaggagca gcgccggtca 2162941 acatcacata gagcggcaga aataacagca acagaattga cgccttttct ctagttatac 2163001 caaggcggat catgatataa aacaaacctg ctgtcaaaat ccccacgtgg agtcctgata 2163061 ttgccaagag atggacaaca ccaagctttt gatacgcggt aagcacttca tcctccacgt 2163121 aaaatctgtc accaactgta agtgcctgta caatccctgt cgaatcagga ggcagaaggc 2163181 tgtttgtgaa tgatatgata tgttttctca agctgagcac cttgtacttg aaattttcag 2163241 gttcgctgca gttttggata gacgtgacag agtagttcca atgaatatgc tgccgataaa 2163301 gatactcgtt ataatcaaat gcacccggca cagttgcgtg attcggttct tccaatgtac 2163361 cagtcaactc acatgacatt cctggttcta tgtataacag ctgttctttt tcaccagcag 2163421 actgaatgcg atacgcagca gcccattttt ccttatcagg tgtctcaacc atcatagaca 2163481 tacggtcgcc gtcaattttg ggaatagtgt caatcactgc cttgaattga taggttccct 2163541 gccgatagga agagacattc tgagaatctg tgactgcata cagtacaaaa aacaatataa 2163601 aagagaagaa acaaacaata ataagaaaag cgtgcctcgt tttgattaaa atgatgagga 2163661 gaaagaggat gaaaagaaaa atagcgggga aataagcggc ggcagtaatt ccagccgttg 2163721 ccgaagctgc cgccataggc aataataagc gcgaattacg cattcatcac acgtagctcg 2163781 tgaaaagtgt attcgcctgt tcatgtatct ttttcaattc ttcctccgct aaaccggcat 2163841 cagccaattt ccctattaga cccgctacaa atgaaagctt ttctctgttt ttcagatcaa 2163901 cgatcatttc atcgagttca acctgttcaa cagttacacc cgcctgttca aataattcct 2163961 gcgcatacgg atgtgttttg taatcctcag cataataaac cgttttgata ccagcttgaa 2164021 taatagattt gcagcattga atgcacggat aatgcgtcac ataaatctcg gctccatcag 2164081 tcggcacccc aaacttagag cattgaagaa tcgcattcat ttcagcgtga atggttcttg 2164141 cgcaatgatc atctatcatt aagcatcctt catctgcaca atgtacgccg cccgcgattg 2164201 acccattgta gcctcctgct atcatgcgtt tgtctctgac tatagtagcg ccgacagata 2164261 atctcggaca tgtgctgcgc agcgccaata aatggctttg agccataaag tattgattcc 2164321 atgaaattcg ttccacgttg ttccctccaa atgttgtgtt gcctgacctt tagtttacct 2164381 atcataatgc atgaccgtca aatcacttta ctgtaatgga agactttatt ttctcaaatg 2164441 acttttcacc tattcctgaa accttagtga tatcttcaat tgtttggaaa cgaccgtttt 2164501 cctcccggta tgcaataata gcttcagctt tggatggccc cacccctgag atgccttgta 2164561 actcctctaa ggttgctgta ttgatattca ccagcgctcc cttccctcca tcgctttgga 2164621 cagaccctcc gccaccttgc tgcactgctg tttcctctcc ctttttcggg atgtacacca 2164681 ctgtcccgtc ctgcagaatc tccgccaaat ttacttgcgc ttcgtctgct tgttcactgg 2164741 tcccgcccgc tttctcaatt gcctgagata ctctgtcccc tgttcgcatt tcataaacgc 2164801 caggatgctg aacagcacct ttgatgtcta tcacaattgt ttcgtttgac tcgtcgttgt 2164861 ttgcttcctg ctttaccact gtattttctg tctctgttgg tacagcttgc ttcaccggct 2164921 ctttattttt ccctgtggcc agaaagatca taatcgctgt gaaaacagcc gcagaagccg 2164981 ctaaaataat tgctttctta tgctgattca accaattcat cgtgcatgtt ccccgctttc 2165041 gtcatatttt attttcataa cacatatggt ttagaggata atagctcaaa ggaggggaaa 2165101 ccattgaaga taggctttat cggcacagga aatatgggta cgatccttat cgaatcattt 2165161 attgaatcaa aagcggccga tccctcaaac atgacaatca caaaccgcac aattgaaaaa 2165221 gcgttgcaca taaaaaaccg ctacaacagc ataaacgtta ccgaaagtct cgaaaagctc 2165281 gtttctgaaa acgagatgat ttttatttgt gttaagccgc ttgatatata tcctttactg 2165341 gcaagagcgt taccttattt aagaaaagat catattctca tttcaattac aagccccgtt 2165401 caaaccgaac agctcgaaca atatgtgccg tgtcaagtgg cgcgagtgat cccaagtatt 2165461 acgaacagag cgctggcagg tgtttctctc gtcactttcg gcacaagctg cggcgaatct 2165521 gcaaaagcga aaatcaatga gctgatgcag catatctctc atccgctgca aattgaaagt 2165581 gacatcacga gggttgcatc agacatcgta agctgcggcc ccgcttttat gagctatctg 2165641 attcagcggt ttatagatgc agctgtttcg gaaacatcag tgtctaaaca ggacgcgatt 2165701 ttgatgtgta aggaaatgct tgtcggaatg ggaaaactgt tagaaaccga attgtatacc 2165761 ctgcctgcat tacaggaaaa ggtttgcgtt aaaggcggtg taacaggaga aggcattaaa 2165821 gcgctggaaa gcggtgtgca ggatatgttt caccgggtat ttcaaaatac tcatatgaag 2165881 tacgaggagg atatttccgc agtgaaaaag cagtttcatg tgtagacgag tatgtcatac 2165941 gttcgtctgt actgcaaaag cataaaaaag cattttaaaa aaccatcgtt ttaggaaacg 2166001 atggtttttg atttctgcgc cttgaaaaag aggcgttctg attgtgctga tggctcggta 2166061 tccgtaaaat cagctgtcac gcgatggagc tgaaagccgc agttcttaag catttcttcg 2166121 tattcttcca ccgggaacgt tctttgctcg tgtgtctcat caaaacgatc atacgcttct 2166181 ccgttccaca caaaaaacga catatcatga atgacagaaa gctcgtcact tccggcaaag 2166241 ctctgccaaa tatagctgat atcttcgtcc tggtcagcaa atgtgctatc cggaaagact 2166301 tccgcaattt taaaagatga atgaacatca aacagcagga tgccttcagg ctttaatacc 2166361 cgaaaaacac ttttaaaggt ttcgatcaca tcattttttg tttttaaata atttaatgag 2166421 tcacagcata tcacaacagc gtcaaattga ccgtcaaagc cggtaatctc tctcatatcc 2166481 tgctgaagaa ataaaatagg ctggctactc gatacctttt gctgggcgaa agaaagcatc 2166541 tcttcgctga gatcgatgcc tgtaacctcg aagccttttt cggcaagccg gatggagatt 2166601 tcccccgtgc cgcatgccag atcgagaata cggccttttt ccgggagaga tgcttcaatc 2166661 cattttgtcc attgatcgta aggcgcgtgt gacattagct cgtcatacac gcttgcaaag 2166721 ccttgataaa tcattgattc attccaaagt caagatctgc gagcggagcg tctccccaca 2166781 gcttttcaag gttgtagtag cttctttcat ccttgtggaa gacatggaca actacatcgc 2166841 ctagatcaac gagaacccat cttgcttcat caaagccttc catctttttg acttgaatgc 2166901 cgttttcatc agcttgatcc ttgatttcac gggcaatcgc ctgtacctgt ttatctgaat 2166961 ttccgtggca gatcagaaaa taatcagcaa ccagagaaat accttccata tccagtgcta 2167021 aaatatcctc tgcccgttta tcatcgcaag ccgcagctgc gatctttaaa atggactttt 2167081 ggttcattca caaattcctc ctgttcagct gccagacaca agccagttat acgttaaaaa 2167141 tgtgtctgga aaaaccggtt gatttttttt cataagaaaa accattgtat ttttaatgga 2167201 ctgaatcagc gcttgattca aatctgtctc agcaagctta cgcacctcat cgacaccggg 2167261 aaatgcccgg tttggctcaa tgtaatcggc aacgtaaatg actttttcta aaagtgtcat 2167321 gccggggcgg cctgaggtat gatacctaat ggcgtcaaga atgtcttcat cttgaacccc 2167381 tgcctctctt tggaccaaat aagcgccgac cggagcgtgc cagagctccg gattatgatc 2167441 caataaatgc gcaggcattt tttcacgcgc aataatttgt ttcatttctt ctttcgggcg 2167501 gaatttggcg taatcatgaa agattgccgc tatttccgct tttttagaat cggctccaaa 2167561 acgctccgca agttcgatcg ccgtgttcat cacgccaacc gtatggatat atcggtgttc 2167621 ggtcaattgc tgcttcacgc atgcaagtgc ctcctcacga ttcatataaa ccattctcct 2167681 ctacatactt cttcacttta tcagggatta agtagtcagt gggcttcttg cttttaaacc 2167741 gttcccttat catagttgat gatacctcaa attccggaac gtctgcaaag agaagcggat 2167801 aaggggtttc aacatgaaaa ccggggcgct ttactccaat aaattgaatg aggttcagca 2167861 gctcgtccag cttataccat ttcggcaaat attcaatcat atcagcgccg ataataaaga 2167921 acagctgatc atttggataa cgctgcttca gtaaagaaac ggtatcaaag gtatatgatg 2167981 gcccttctct ttccatttca acaagctcca gcttaaagga cggattagat tgaattgcaa 2168041 gctttagcat ttccacgcga tgaaagctgt cggtatagtc ttcgttctgt ttatgcggcg 2168101 gaatttgatt aggcataaac caaatttcat caagccccgc ctggtacagc acctcattcg 2168161 ccattaagag gtgaccatta tgcggagggt caaacgtgcc tccgaaaatt ccgattttct 2168221 tcatttcaac cacctttaag gaagctcgat ttgtttattt tcctttgatt ccttatataa 2168281 cacaatcgta ttgccgattg tctgcaccaa ttgagagcgg cttcctttta caagagcttc 2168341 cgctacatcg tttttatcct cttcgcaatt ctgaagcacg ctgactttaa tcagctctct 2168401 cgcttcaagc gcctcagcaa tttgtttaat catgttgtcg tttactccgc ctttacctac 2168461 ttgaaaaatc ggcgttaaat gatgcgcttt tgaacgcaaa aaacgttttt gtttacctgt 2168521 taacattctg ttcctcctaa ttttcctatt acaatagatc tcattttttc aatattaggc 2168581 tcttgtccag tccacaattg gaaagacaat gctgcctgtt caacaaacat gcccacacca 2168641 tcgagtgttt tcaagccttt ttggcttgct tcttttaaaa gtgccgtctg tattggatta 2168701 tacacgatat cacatacgac ggcactgctc gcggcacgct gtaatgaaag cggcacatcg 2168761 tccacgttcg gatacatgcc cacagacgtt gtatggatga taacatcata ctgctcaaga 2168821 cgttcttctg cttcttttat gcttaatact tctttattgt gaaacgaggg agtagcttct 2168881 gtaagccgct ttgctttttc taacgtccgg ttgcaaatgt caaatttttt cggggtattt 2168941 cggacaattg ttgtaaaaat ggctctcgcc gctccgccag cgccgatcat taagaatgac 2169001 agttcagaga tgggcttgtc taataccttc attaatgact tcacgaagcc ttccccatcg 2169061 gtattgtatc cgacaagctt atctccctct cttctgaccg tgtttacggc accgagcact 2169121 tttgcactct catcaatatg atccaaataa tccataatgg aaaccttgtg cggaacagtc 2169181 acattgattc cttgtacgcc tagagctctt attcctttta ccgcatcctc cagatcattc 2169241 tcttctacct tgaaggcatg ataatgtccg tcaagcccga ggtctttcaa tgatgcgtta 2169301 tgaatatcag gtgacataga atggccaata ggatttccga taaccccgta cagctttttc 2169361 atacacctct ccccttttct taaattaatg aacgccgaac aaatacatga acgccttttg 2169421 gcgcgtatgc agttaccttt ttatcagcgt catggacagt aacccagcct aacccagaga 2169481 aaacgatatc tgtctttttg tcttttatcg taaacgtatg ggcgaccaat tcaggaaact 2169541 catccatttc atctttaccc ggaggtgtga gcaattcccc tgcatgcttt tcataaagcg 2169601 cgtctgcatt ttcaagtttt gttctatgaa tcatcagctc attcggcata tagcaaataa 2169661 aaggagatct ttccccagac acataatcaa accttgcaag tccgccaaaa tacagtgttt 2169721 gctgatcatt aagctggaat gtgcgaggct tcagctcctt tttaggagat aatattttca 2169781 ggtccttttt attgacataa tgcgccattt gatggttgtt gataattccc ggtgtatcat 2169841 aaagcgatga accgtcatcc agcgggattt caatcgcatc aagggttgtg ccaggaaatt 2169901 gggatgttgt aataatatct tcttcacctg acacttcttt aataatccgg ttaataaagg 2169961 ttgactttcc tacatttgta catccgacaa catagacgtc ttttccgttg cggtaatgct 2170021 caatcgcgtc aattacttct ctgattccct ggccgcgacc cgcactgacc aaaaatacgt 2170081 caaccggttt taagccaagc tctttcgctt cacgcttcat ccattggatc agacgctctc 2170141 ttttcagtga cttaggcaaa atatccgctt tattgccaac taataagata gggtttcccc 2170201 ccaccaagcg ctgcagccca ttaatccagc tgccgttaaa atcaaaaata tcaacaattt 2170261 ttacgaccag agagtccgtt tctccaatac cgtgaagaat gttcaaaaaa tcatcatcag 2170321 ttaaggagac atcttgtatt tcattatagt ttttcagtct gaagcaacgc tggcaaatca 2170381 cattttcttt cgtaagcgat gcaggcggcg cgtaccccaa acctgttttg tcctcggttt 2170441 ggatcgtaac tccgcacccg atacaaacaa ccttttccat ttcttactcc tcccactgaa 2170501 tgtgcccttt tcgtttgaga gcactcagta ttctgcgttc gacctggcgg ttaaagcgcg 2170561 taatgaatcc gtcagaggaa gcgactggca cgaccaaaat cgtatggtag ccgtttcggt 2170621 ttcccccgag tacatcggtc agcagctggt ctccgatgac aacgcagtcc tcttttttca 2170681 gctccatatt gcgcaccgct ctattaaagg ctttacccat cggttttctt gctttataga 2170741 tgaatgggat tccaagcggt tctgagaaaa gtttcactct tctttcgtta ttattagaga 2170801 caattgtcac tttaatgccg tgttccttca tttcttcaaa ccactcgatc aatcgcggcg 2170861 tcgcgttcgg cctgtcccat tcaacaagcg tattatccag gtcagtaata attcctttta 2170921 catttcgttc ctttaatttc tcaggtgtaa tatgaaaaat attttttaca aactcgtcag 2170981 gtaaaaaaaa cttttttaac aaaacccgca cccttccctt tttctttctt tcaaaatgat 2171041 tgtcgaaaaa aatcgaactt gcgcctaaag aaaaactgag caaaaaaatt tcgacaaaaa 2171101 ttgggtttct tcaccaggtg tggataaatt tacacacact atccactctt attacatcac 2171161 tctttagaca aattataaac acgatactca caagttatcc actttttggt gtggataaca 2171221 gaacgattgt tcttatatgc atttcatggt agattaaaga taacttcaac ctcagatgaa 2171281 tgcaacttat cattgtatgc gttaaaatca tgaatgattc caacttttaa ggaggtgcct 2171341 ctcccattaa ttgggttcct agcatgagaa aactgtctga tgaattacta atagaatctt 2171401 atttcaaagc caccgaaatg aatttaaacc gtgactttat tgagttaatt gaaaacgaaa 2171461 taaaaagaag atcgctcgga catattattt ccgtatcttc ttaataggaa tttgtctatt 2171521 ttttccgggc gtatttcctt tttttactca gatgactgat attatatcac tttggctgcg 2171581 cgctttacta ctattttcag caaaaaacac ccctaaaaag aggtgtttta aagggccggt 2171641 tattatgcta accagtatat gccgcccaca acaaggagaa caacaactaa aacaacaata 2171701 aaagcgtatc catatgctct gcctgcgcca tacatgtgaa gcgcctcctt aataaggttt 2171761 tataacagcc tatgtaggag aaataaatcg gactaggcgg ttgtccggct caacgctgca 2171821 ggatctgccc cgcgaactaa tttattaatg ttcaacaaca gaatttcgtc tattggcaat 2171881 aaagaatcca caaatcattg caagaatggc catcgcccac cagaacgttg agatcgcctg 2171941 atcatgatcg atgataatca aacgaatgac agctgtgatg ccaatataaa tgaagtagcg 2172001 aagcggaaaa tgaaagtctg atttgaagta tttgataatc aaagcaatga actcaaagta 2172061 catgaagaat ataagcagtt ctccaagcat ctcataatag ctgtccactt tgttgaacag 2172121 tgacttgtat acgaatagca caatgtacca agtctcgctg atcagaagtg cgcttaaggc 2172181 taacgccaga aagaacagac agacgttgag aagcgcttgt aacaggtaag gcaccttttt 2172241 gaatttgtta gaaaatctca tcatgttgtc tcctatttca atatattcgt ggtttttatt 2172301 ctcagcctac atcttggtgt tccaaaatcg tagcacaatg tagtacttag aattcttttg 2172361 tatactgtga aactgtccct gcatgcggga catcattcgc gcaatgcttc tttcaccgag 2172421 tccgttgctt tccggtgtta tatctgcaag tttaatcgta ttgctaacat ggatctcaaa 2172481 tatctcttga tccgatacaa acgtgatact gattttttct tccggatctg cgtatttcaa 2172541 taagtttgac atcacattat caaatacacg accaagctcc tccaaattca cgttaatata 2172601 ggtttccggc agctcgcctg aaatatggac ccgaaaatgc tcctgatgaa ggatagcaat 2172661 ctgatctgat attagatcgt agatcacttc tttcactgca acggtctcca gatcggcctc 2172721 atattccttg ttcagcagga aatacgcaaa cagattgtca gacaagcttt ttaattgcag 2172781 tgctttacca taagcattgg ctacataccg atctttgctg gcacccgctt cgcctccctc 2172841 ttttttggca aactccagat tcatgatcag cgacgtcagc ggtgtgcgca tatcgtgcga 2172901 catttcggta accaggctgc ggctctcagc ttgcaattcc tcgatagctt taagtttatc 2172961 caggaaagct ttccgcagat cctcaatgct ctttgcaatc atcgctaatt catcatgccc 2173021 ttttatcgtc atctcgtagt ccagttcgcc cccttcaaga atatgaatct cttgatgaat 2173081 cgttttaagg tagcgaagac tttggcgaat tccgaagaga acaatgatta aaaagatgag 2173141 ggttgccccg agcaaatcca atgcaaaggc cagatcataa tatcgggaag agtagaaacc 2173201 gtcgataatg actcgtcctt caccatcgct aaacttgaca ggatgtgaat gattttgagc 2173261 gtactgagtc agcttttcct ttccataatc cgattcggaa taaatagaat catattgcag 2173321 ctcctgatcc ttgaatatgg tgaggttaat gtaattttct tttttgaccc actcgccaaa 2173381 cgcttttcta tctgatgtag acaactcatt ttctgaaacg tacttgctga atttttgaat 2173441 gtatcttgct gactcctcgt gataatactc ttccgaactc agatatccct cgatcagatc 2173501 atctgtgatc ttttgcaacg tcagaaagat cacaccactc acaatcgcag caaccattat 2173561 cagcaaagcc agttttttgg ttagcgtaaa tttaagatgc gccaaatcga tatcctcttc 2173621 cccattcagt ttttatataa accggacgtg ccggatcatc ctcaattttg gagcgcagct 2173681 tccgtatatg caccatcacc gtattgttgg aacagtaaaa gtaaggctgt ccccacacac 2173741 tctcatatat attttgggca gaaaatattt tgttgcgttt gttcatcaga agtttcagga 2173801 tacgatactc cagatctgac aacttgattt gcttctcctc tttccacacc tcattaaatt 2173861 cttcgctcac tcttagtttg cccccgataa gaaatgtttc ttcctgttcc ttcttttcct 2173921 gatagatagt atatctgcgt aattgagcaa tcactctagc gtgaagttcc tcttccgaga 2173981 atggtttagt catataatca tcgccgccgg cgagtaatcc ctcagtttta tcgagtgtac 2174041 tcgatctggc cgtcagaaac agaatcggga cgttagagga tttcctgatg tgctgacatg 2174101 tttcaattcc cgaaatgcct ggcatcataa tatccaaaat aaccaaatca agcgagtcat 2174161 tcacaagttg caatgctcgc tttccatcct tggctcttag cacctcgtaa cctgcacgtg 2174221 taagggattc ctccaaaaga tcaccaatat cctcatcatc ctctacgact aatattcgat 2174281 aggccatgtc tctctcacct catgattctt gttgttattt ctcgtgtgtc cttactatat 2174341 atcgttcata gtaataagta cgttataaga tactacgtaa atcttaacaa tttatgaaag 2174401 ctgatgctcg ccacaaattt gtcacatttt ctaaaaaaaa tgatgactct tcataaattg 2174461 ttaagattcg gtctttatat ttatccattg taaggctcaa gtttttcaga tccgcactac 2174521 acattgccgt gataaatggg aaaggagtat tgatatgatt gtacaaaaag aaggacgcgg 2174581 gcaaccggtg agtctgcggg aacgggttca ttttctggac atcgtacgag gatttgcctt 2174641 gcttggcatt attattgtca attattttct gatcgtagat tcagtaaagg gattcgaaat 2174701 ggcctccgat gacgtactgc ataagctggt ttcctggttt gccgaaggga aattcgttac 2174761 gttattctcc ttcctgttcg gagtcgggtt tatgatcttt atggatcgag ccgcgcagaa 2174821 ggtagagagt cccaacaagc tgtttgcccg caggttatct atcctgttgg gatttggcat 2174881 tttgcacatc acatttgttt gggtcggtga catattggcc ttttacgccg taagtggctt 2174941 cctgttactc gccttctata aacgcacggc caaaacggtg cttagatgga ttatcgcact 2175001 tatcgtgttt caattcctga ctcctgtttt cacaatgttg tacaatgtca tcaatactgc 2175061 agggtcaaaa aacccgaatt tttcagagtt tactttgttt agccacagca gccttaccta 2175121 catggaatcc atcagcactc ggtggacaga tatggtcacg atggctgccg gctctttctc 2175181 tatgatctat tccatgtttc tcatgtttct gctgggcgtg tactttgtta agatggaatt 2175241 tttcaaagac atggaagcga aaaagcctat atggaagcgt atctggatca ttagcacaat 2175301 cgcttttcta ataacacaaa gcagtatatt actagacatg tttaatcttt ctgagaatat 2175361 gctgtggaag gacatttcct ctgtcttggg tcaaaatggc ggcttaaccg gaagtatgtt 2175421 ttatatgagc acttttgcaa tgctgtttct ataccttcct cagctgcgag gccctatgat 2175481 gatattcacc aaagtcggac ggatgtcatt gacctgttat ctgcttcact ctatcattgg 2175541 aacagttctg ttcctcaggt acggattcgg gcttgcggat catattcaat ccgccggcac 2175601 gttcatgttc agtctggccg tgtacttcgt tcttatgagc tttagtacat tgtggttgaa 2175661 acggtttagg tacggtccga tggaattagt atggcgcaag ctgacgtacg gcaaagtaaa 2175721 cgggagtccc aaagcaactc cgctgcattc ggaaaaatct attcagaaat aacccccttg 2175781 cacagattgc atgacttcaa attagtgttg ttgaatgaag cgggcattaa acggacagat 2175841 ttgatatatg gactagttat ttttatatca tttaggcttc tttgggctaa taaatccacc 2175901 agagtttact caatgtgcat tgctcatgat cgaatctaaa ttgaatcttt tacgcatgtt 2175961 catagtcaaa ggcgcctcat tcgactattt ttgtaacttt tcgcaggaaa aattcgagaa 2176021 tgatgacaaa tcccgcatac gacacttaat acggtagtga acaatagtaa attagggtta 2176081 catgcagctt gttttccaat gaaacaaaga aaaagaatca tacaaaaaga caggagaaag 2176141 cttttgaagt attttaacgc caaatttacc gcggaagaaa gagcgatgga atcacttttt 2176201 tgtgaaaagg cctcgcagag cagctcgaat gttttactga acgactgaac tctatatttt 2176261 agcaactgag ggagtgaaca atcatgaaaa ctaaaaatga accaaaagtt attctggaac 2176321 tagcaaagga atctgatctg ccagaattcc aaaaaaaatt acaagaagcc tttgcgatcg 2176381 ccgtgattga aacgttcggt gattgcgaag atgggccgat tccatcggac aatgatgttc 2176441 aggagtcttt caatgctccc ggagcagtgg tatatcatat tcttcaggat ggtaagaatg 2176501 tcggtggtgc agtagtacgt atcaacagcc aaacaaatca taattcgcta gatttattct 2176561 atgtatctcc agaatatcac agccaaggga ttggtctttc tgcttggaaa gccattgaag 2176621 cacagtatcc ggatactgtg ctttgggaaa ccgtgacacc ttatttcgaa aagcgaaata 2176681 tcaacttcta tgtgaataag tgtggatttc atatcgtaga gttctacaat gaacatcact 2176741 ctaatccgca tatgcatcgc aatggacgtg aagatgacaa gcccctactg aatgatgatg 2176801 actttttcag atttgtaaag attatgaaaa aaaaggacta aacaattgaa cacggcgaga 2176861 tgccgcagag agttgctggt aactttttta tatttcatta tcagaggaag gtaataatga 2176921 tgtttaaaag gtgttttgat ccctgtctca taaacagggg tcaaaacacc tttgaatcat 2176981 cggtttcttt tctgacatat accacgccca ctagtccctc aacatagtaa aaacatatca 2177041 tgagttacaa aagcttttat tcaaagcata tgtttatttt atttatactt attttcatca 2177101 tttttcagaa ttctggacac aaatcgggta cctattagag gccaaggaac tctacatttc 2177161 attaagaaat acgtactcat tgccctgctt taattaattt taagccctcg cactatgccc 2177221 ccccctgaat taagtatttg atgtaacttt gaaattaagt ttatgaaaat ctgtcacaaa 2177281 cccttatttc ataacacatc atttgtttca gcttccctcg cgaataccgg attaatgctc 2177341 ggctttaaga tagtcaacca atctctccgc actgttctta acatcttctt ttgaaagatg 2177401 aagtgtccca tattgtgtaa acgcaggaag aaaacgcatt cctatatagt tagcagtgac 2177461 ttgaaacggt ctgataagct cgctgatcgt gatattatat tctccgcctg cttgataatc 2177521 agattcctgt gcgcctaagg agatagctaa gagtagttct tttccatgca atttagttcc 2177581 tccagttcca taagcccagc catgtgttaa cacatcatct tcccattgtt tgagtaacgc 2177641 gggactgctg taccaataca ttgggaactg aaaaacgata cgctcatgat ctaacaggag 2177701 ctgctgctct ttttctacat caatgataaa attagggtat tcaccgtaca ggtcatgaac 2177761 cgtaatgtct ttctcttgct ttaaacgatt catccaggtt ttgttgacaa cagacgtttc 2177821 caaattagga tgtataacga taactaatgt tttcattaga ctgattatcc tttctttgcc 2177881 aattagttat tattttttac gataatgaat tgattctaat tttaaaatag caactttatt 2177941 tacacctatt ttatcctttt tcatgaattc agggcaacta attgggcacc aaaatcaatg 2178001 atgacttaag acattgtttt gtagaaatcc gatatacaga ataatccatt atttagaaaa 2178061 tttctacctt ttccctcaat ccgagctcgc tcttcatgcg gatggcctat tttaaaggaa 2178121 taactgacta tgttcatcag ttattccttt aaaatacgaa agtctacgat atttccatat 2178181 cgatccgctt caatgtgaca gcacccctca agcagctgtt ttaattttcc acgtccgcgt 2178241 tgtacccttg attttgctcc ggagtaagaa atgccgagct tttcactcaa ctctttttgt 2178301 gataacccct ggaaatcagt taactcgagc gcctctcgat acttttcagg caaccgtttg 2178361 atggtcgatc gaatacacac agttgcttcc ttggtgaaat tttcttcctc tgcactgtca 2178421 ttaaaatgta gaacatcagg caatatttcg cttgtttttt ttgtacggta aaaatcaata 2178481 atcgtatttc tagtgatccg ataaatccag ctgtcgatct tttgttcatc gatcagattt 2178541 gggagatgca cttgtatttt cataaatacg atttgcaaga ggtcatcaac gatagattga 2178601 tcgttaaccc tatgtgaaat atatgttttt aacggctgat gaaattgatc ccatagatcc 2178661 tctatattca tttgaaaaaa cctcctataa ttttgcgtct gctttacatt tgcttcgtct 2178721 ttttaatcgt aacaaagagc aaacaattgt tgaatcaatt gtattgcagc tgttgccaaa 2178781 aataatgata aaggagaggt ttgttgtgga gtatacctat ttagggagaa caggattgcg 2178841 ggtgagccgt ttatgtttag gcacgatgaa ttttggagtt gatacagacg aaaagactgc 2178901 gttccgtatc atggatgaag cacttgataa cggcattcaa ttttttgata ctgccaatat 2178961 ttacggctgg ggcaaaaacg caggattgac agagagcatc attggaaaat ggtttgcaca 2179021 aggaggacag cgccgcgaga aagttgttct ggcgacaaaa gtatatgaac cgatttctga 2179081 tccgaatgac ggaccaaatg atatgagggg cttgtctcta tacaaaatca gacgtcatct 2179141 ggaaggatca ctgaagcggc ttcagacaga tcatatcgaa ttgtaccaaa tgcatcatat 2179201 cgataggcgg acaccgtggg atgagatatg ggaagctttt gagactcagg ttcgctccgg 2179261 caaagtagac tatattggat ccagtaattt tgcaggctgg catttagtta aagcgcaagc 2179321 tgaagctgaa aaacggcgat tcatgggact cgtcactgaa cagcataagt atagtttatt 2179381 agaacgaaca gctgaaatgg aagtgctgcc ggctgcacgg gatcttggtt taggagtagt 2179441 ggcgtggagt ccccttgcag gagggcttct tggcgggaag gcattgaaaa gcaatgccgg 2179501 aactcgtaca gcaaaaagag cagatttaat tgaaaaacat cgtttgcaac tcgagaaatt 2179561 ttcagattta tgcaaagaac taggagaaaa agaagcaaat gtggctttgg catgggtgct 2179621 ggcaaatcca gttttaactg cgccgatcat cggaccacga acggttgagc agctgcgtga 2179681 tacgataaaa gccgttgaaa tcagtctgga taaggagatt ctccgcatgt taaatgatat 2179741 ctttcccgga cctggaggag agacacctga ggcatacgcc tggtgataca ttcattactc 2179801 aatactgaca tttttcttaa atatttatac tgaactatca tattaagaaa gacaagagca 2179861 tgtttgtctc ttgtcttttc cacatcgtgc tgaaaatgct ggctaaacat cgacaaaaat 2179921 gctgccgctt aaaaaagaac cctaaacaat agagtaactg gaaagacaac tggcttgatc 2179981 agcttgggac ccctttcagc tgtatttaaa tcaatcaaac taatgattca ttggcagtct 2180041 aaatattatt attgtttctt tacaaaatag taatagcccc tgtaatgatt gctaacaacg 2180101 taataactaa tgatgtaatt acagcccact taacggcaaa cctttgaaat gaccccaagt 2180161 ccattttaag catgcttact agcaatactg ttgacgcaac caatggactc atcagatgaa 2180221 ccggctgccc cattatagaa gcccttgcaa tttctactgg ttctatacca tatgctgagg 2180281 cagcttctgc aaagataggt accataccaa agtaatatgc atcatttgat aaaacaaaag 2180341 taaacggaat actagtgagt gctacaataa cggggaaaaa ccctcccatt gatgagggga 2180401 tgatggatat taatgatcct gctatggcat ccaccatctt tgtcccggat aatataccag 2180461 caaatactcc tgctgaaaat accaataata ccacggttat ggcattacca gaatgctcgg 2180521 cgattcgctc cttctgcatt tttacattcg gataatttat agtaagggca agaacaaaac 2180581 caattaaaaa taaaactgac ggatgcttag ttccaagcac aataaacacc atgatactta 2180641 taacgaggaa taaattaaga tatattaagc gtggcctttt caattgttcg ctctccaaag 2180701 tagcagccat ataagattga gagctgtcct ttgttatatg tctaggctct aattgaacga 2180761 tgcctattcg attcctctct ttccttccca ttagaaaagc cagaaatatc acacaagcaa 2180821 tacctccaag catggtcgga agtaatggca caaagaaatc tgaaggatcc aaacccagca 2180881 ctgaaatcgc tcttgtagct ggtccgcccc atggagtcat tccgctaacg atactcaacg 2180941 acagcattgc taatgtcgcc ataaccatgg gattcatacc aattctttta tacaaaggta 2181001 acattgctga gactgttatc atataggttg ttgtaccgtc cccatctaaa gcgataagca 2181061 ttgccaagac ggcagaccct atcgctattt tcacagggtc tccctttact atagataaaa 2181121 ttttttctat tagcggatca aataaacctg catcaattaa aattccgaaa aaaagaatag 2181181 caaacaatag caatgccgct gaacttgcaa ctgtttgaat tccttctaaa atcatgtcgc 2181241 caataccctt accaaaacct ccaataagag caaaaacaat gggagtgatg gtcaaggcaa 2181301 caataggcga gactttcttt gtcattatta atattgtaaa aacagttacc atcgaaaaac 2181361 ctaaaatagt aagcatatta cacctccaag aatgcgcttt caaatgactt ttgattaaca 2181421 tatcttatac ggtgtaataa gttaaataaa tattttttta ctgtgtttca aaaaaaattc 2181481 tatcataact ttaaatggtt accatttgtt caccctttaa aaaatcaatg aatgctttaa 2181541 cgagtttgat tcctaatgat ttttgatcgt acattagcca agtatctctc attagaggct 2181601 tacccttagc attatacagt tccattgtgt acaaatgatc agattcctgc aggcaaattt 2181661 ctggtgctat ggagtaacca agaccatgct ttaccatctc tttgcaagtc tcttgtcgat 2181721 ccacttccat tgcaataatg ggggcttgtt ttagattcgt atgcatccaa tcttctataa 2181781 tcgtttttaa agaagcatcc gttttatatt tgataaaagg taaaaaagga agttgctcta 2181841 tcgttattgg tttttttgag atgatatgta atttttcccg tgtcagccgt tcctccaccc 2181901 ctttccagcg atggcttcct ctcagtatac cgacttgtac aataccagca tctaataatt 2181961 tcatgacatc tgtgctccag cctgtttgta cactatattg gacattagga tacatagtgg 2182021 aaaattccct taataactta gggagcttat attgagcgaa attgcttgat acccccagcc 2182081 ttagatgtcc ttgcacctct ttgcttagat tagagatatg atctttggta tcttgaagtt 2182141 cctgtagcat tcttcttgca taagcaacca agtgttctcc ttccgcagta aaggtaattc 2182201 ctttatgcct tttggtgaat aattcaattc cgaaaatctc ctcaatcttt ttcaaccgat 2182261 aagtgatgga aggctgtgat gtaaataatc gttctgctgt ttttgttaca ctttgttctt 2182321 cgtgaagaat tttcaataaa atccaatctt tctcatccat tttcatcttc ctttctagtc 2182381 cttctttcac aattataaaa gtttttttat cgaatattaa gaaaacttat attttatttt 2182441 tattttttta ccttctacac taaaaaacat aaaaaatact acctttaaga tgaggatgat 2182501 gacgatggtc aagacgaatg taacaatcat gagaggcgga acaagcaaag gcgttttttt 2182561 ccacgaatca gccatgccta acaataaaaa cgaatgggag ccctttttgc ttgatgtcat 2182621 gggaagtcct gataaaagac aaatagatgg tttgggtggc ggtaattccc ttactagtaa 2182681 agtggcaata ataaagaaag catatacttc ggatattgat gttcactata ctttcggtca 2182741 agtcagcatt tcggaagaaa aggtggactt taaggggaac tgcggaaata tctccgctgc 2182801 tgttggtcca tttgctattg aagaaggact tgtaaaagcg aaagaaccaa tgactgcggt 2182861 aaggatcctg aataccaata cgaataaaat gatcattgcg gaagtagaag tggaagacgg 2182921 tcaggtcaaa tatgacggag atgttacgat atctggagta cctggatctg gatctccaat 2182981 ctatttaaac tttcatgatg ccgctggttc agttaccggt catttattgc ctactggaaa 2183041 tagttcggag tttttagata caagtcaagg ccaaatagag gtgtctatta tcgactatgc 2183101 aaatccatta gtttttgtgg aagcgagcag tatcggcctg gatggaacgg aacttgcaga 2183161 agaatttact gatctacagt tggctcaatt tgaagaatta agatccattg cggcagagaa 2183221 atgcggcttt gccagtcgat tttcagctac aaagttatcg ccggctgtcc ccaaactggc 2183281 tatagtagca aaaccagaga aatataaaga tagtacaggt gcttggcatt caagcgttga 2183341 gatggactta cacatcagga tgatgtccat gcaaaagcca catcaagcac tggctgtcac 2183401 tggagcgata tgtacaacaa gagccctttc agtggaaggt gcaatccctg caagaatagc 2183461 aaaaaaccac tctacaaagg ttcggctagc tcattcttct ggtattattg aaacaatggt 2183521 ggagcccact ggtataaaga tcgtccgtac cgcacgacgt attatggacg gaacagttta 2183581 tacgcatgga gactatcaaa tgatgtagat ggactgtgca aaaagcctcc cccctttcca 2183641 tcgttaatag atggattgaa tgcgccttct tgcacagatc cattgtaatc ttgcatggct 2183701 ttaaaaaagc ctctatattg ttttttatga aatcgccaag gtcctttcat gtatctgcct 2183761 caagcatgac ataatcatta tagagaaaat tgaatacttt ttactgcaaa taaaaagata 2183821 ccaacatcat tggtatcttt tagattgagt tcatctgcag cggtttcttt tcctcactgc 2183881 ttatttgatt acaaaattac cgtactcgtt tgaacgaaca tgaatcggtc cgtttagatt 2183941 atagttgttc tccttggcga tagagcgaag cacgtccaca cgggcaactg attctctcca 2184001 ttcgtcacgg gtgtcatgat tggccggatt catcagatcg tcatagcgta cgtccaagaa 2184061 tttattcaac cacttcttct cgtctattcc gtctttaggt gatccgcccg cttttttgtt 2184121 cgtacgttta atcaaggcat aaaaagagtc agggtcatca ccatcgccat gctgaataac 2184181 cgtatcgtac atcacagctc ttgccaatgc tgtttttagt ccggcattat ccgatcgttt 2184241 catggcaggc tgataataca aatggtcatt tactttgtct tgagcggcgc gaaattcctt 2184301 atcatttgca agcgacttcc aggcagaagc gaatcccttg agattgcttg tatcatcgct 2184361 ttcttccttg gccagacggc gcaattcagg cagatacttt ttcagtttgt tattcggaac 2184421 tgcctttgtg tatacttcca ctacttccaa tgcatccccg gtagccgttg taaagcctgc 2184481 ccgtccgcat gtatagcctc gcccgtcatc caatcgctct acatatccat attggatctc 2184541 cgttgtgccg ttttcaaaga tacttgtcag ctgttccgcc cggcgctttt gatctttatt 2184601 cagtcccgcc gcaaaaaccg tttcgctcat catcagggta aaaaacatgg tgaaaacaag 2184661 taatgagatc gctgcttttt tccaaaaatc tgctttttgc atactgattt tcatttcact 2184721 tcccctttct aaatattgta aatacagact cagtatacat gaagaaactg ccctattgtt 2184781 gaaaatacat caatttgtca atattttgaa tctaaagtaa tatagcttga atcttactct 2184841 attcattgcc aatcagcctt agcccctctc actgggaagg tcccttgatt ttcatactgc 2184901 ttcaactttc attaacaaga tgccataagg ctttactcta ttttataatg gaagtgatca 2184961 tcgaaaatcg ttagggaggt gatgtaatgg caagcaagat gagaatgcca gattccgcaa 2185021 cgtcccatgc aaagcctact attgggaagg cgatactttg catggggtag actttctaaa 2185081 agatcgccca agtaagcttt tctgatatag tggctttgca ccttatttga cataaaaaaa 2185141 taaggagctg gcagaaatgg catatgtaaa agcaaccgct attttacctg aaaagctgat 2185201 atcggaaatt caaaagtatg ttcaaggaaa aacaatatat atccctaaac ctgaatcctc 2185261 tcatcaaaaa tggggtgcgt gttcaggaac aagaaagctg atcgatgaca gaaacgcttc 2185321 tattaaaaaa gcatttaaaa acggcaaaac cattcatcaa ttatctgatg aatatcacct 2185381 ctctattgaa acaataaaaa aaattgtcta ctctaaataa acaaaacgga agcactgata 2185441 aaaaataatc agtgcttttt atatggcgag tttgtttctt agttatttcc tgcatatgat 2185501 accattggcc aattgtgtaa agttaaggga gatgagaaga aaggaaggtc ctacaaatga 2185561 cgataaacaa tggaacgttg caagtacccg gcgcgaacat ccactatcag gtgcgtggct 2185621 ctggtccaat cattcttttg gtccacggag gaggcggtga tgccgacaag ttccatcatg 2185681 ttgccaatca tctggctaac tggtacacgg ttgttactta tgatcgccgc ggccattccc 2185741 gcagcaatct cgccaatcag attgagggtt accgtgtgga aacacacagt gacgatgctc 2185801 accgtcttct agccaaaatc accaataagc cggcctatgt atttggaagc agctccgggg 2185861 ctgttatcgg gcttgatctg tgcatacgcc atcccgaaca agtacatgtc atgatcccac 2185921 acgaaccaat cttattgcag cttctgcatg gaaatgagct gaaacaagcc gagcaattca 2185981 tggaagacct taagaaaaat catcgaagtg aagtcattaa attaatgtca agattagaga 2186041 cagacgaaca atcaaaggct gtcctgacaa agcggcttct cggcaattca acgtatttca 2186101 ctgagtatga aattcaagga attctcagct atacattaga tttcgaagca ttaaaaactg 2186161 tgtttacatc ttcaccgatg aagatactcc cagctggcgg aagtgcttct cgggagcttt 2186221 ttccttatcg ttgcgcgaac gccctagcgg aacaattgga aacagaatgg gttgaattcc 2186281 ccggaaatca tacggggtac acaatgtacc ataaagaatt ttctgagagg ttacacgaca 2186341 tgttagaaaa agaaaagaaa catacgtgtt aaggattgat taaaattttc aaaataggac 2186401 aggtgaaact aactatggaa ttggagaaga tttcacgaag cgtaaaaaga acttttcact 2186461 aacgagaacg caatgtgaga tgtttaacca aagtgatatt agggatttca tcgaaaaata 2186521 ggtttgtaca ttacgttctc ctattgatta tttcctatct taattccgta ttttatacca 2186581 ttagatacaa ctctaaagcg gctcgttatt ttgtcctcaa caacaaccag tgtctaacat 2186641 catgaatctc ttttgaaaat caccacaaat gcaggtatgg aagacttcat cgcagcaaaa 2186701 accataccaa ctattgttgt tggtatggtt cgtcctagat aggcccttaa gaagagattc 2186761 tattgtacgg agtatttagc taattgcatt tgtaaccgac agggccgtct gaacctgtgt 2186821 acacatatgt gtcagacaca tatccaatat tcacgacacc ccgggaatct ttccactgga 2186881 tttggtccca gatattactc gttccatact tccctgtaac agtcgttcca taagcgtaac 2186941 aataataagg aacacgggag ccactcggaa tggaaagcat aataggataa tttgtaccag 2187001 gaccgctgcg catattgaca ggcgcaccgc tgcttgttga gacagtaaag tactgaacgg 2187061 caagtgcctg actggaaaaa atgaataaag atgcaatcat cacggttaac atactcagca 2187121 ttttcagttt agtcaatgtc atccctcttt cttcaattcc ttcattttaa gaaacgatag 2187181 aacataggct accagctgca tttaggaaca accggaccgt ctgagcctgt atacatatat 2187241 gtatcagaga caaatccagg aacgatctcc ccgctggcaa gcgtccgctc tgtgtaattc 2187301 caaatattgc tcgttccata ctttccagtt acagttgtac cggttttgta gcaatagatc 2187361 gggatgcggg ttccgctcgg aatggtcgtt acaattcccc aacttgtacc tgggccgctg 2187421 cgcatgttga caggagcacc gctgcttgtt gaaaccgtat aatactgagc cgcaagtgca 2187481 tggctagaaa aaatgaacac agatgcaatc atcaccgtta gcatacttag cctctttaac 2187541 ttattcacct tataccctcc ccttataaat gccgtacgtt tgactttctt acatccagtt 2187601 aaggatttac tttcagatac catgccccct cccctcccat atatttatca atgtaccata 2187661 aactagatct ttcaaaagtg gaattattcc tatgttttcg acaattaagg atacaaaata 2187721 aatggtagtc aggcttgata ttgatggtgt gttacatttg gctcttaatc atttgtccag 2187781 tcggtaatca cgattgacaa tcaggaaaaa ggacatggat caagcggctt cgtttccacc 2187841 aattaactca atcagtgtac tgcttccttg tatccacgct tcttctcgat tcatagatac 2187901 tccacctttt tcaccaatca aaaacggaca ccatacaaat cagcgtaaat gctgcaagtt 2187961 cagtgtccgc aacctattat gactttgctt tcttttacca gggcgtgtaa aaatgattag 2188021 gtacgttatc aaacgttatt ctatgatttt gcgagtcaaa aaatcataac attttatata 2188081 tttcaatcag attatgatct ggatctctga agtgagcaac tcgggcactc cattccttgc 2188141 gatcatgcgg tttattctca catttaactc ctttttcgtg taaatcgtca tacgttttat 2188201 caacatcttc taccttaaac tgaagcaaaa attttgattg agcttctcct tccaaggact 2188261 ttttttcctc tccaacgatt tcagccatcg tttctcgaga taaaagctct attttcgttt 2188321 ccccattatc aaagagtgca tattccattt cattctctaa ccaacttatt ggaagtccta 2188381 atgaatcttt ataaaactcg acgcttttct taaaatcatt caccaacagt ctaatttgta 2188441 acagcttcat atcgagtgcc tcctataaaa ccatactttt actggtcatc caatttaatg 2188501 ataccaaaga aacctgacag cactatgtca agtttccata cttcaccctt atttcagatt 2188561 taagtgcagt ttagtccatg tcataagaac gagcaaaaac agcgattctt aaaacaaaaa 2188621 atgataccga gtgtattttc tgtatgcttc aacttcattt cgggaaatgt aacgttgata 2188681 aaaggaggtt acatcaatat ggatcatcaa acattggcag ctcatgaggc tgttgactta 2188741 catgaaatcg tgaactttaa aacactttgt atagcgaaat caaagttaat gcaagggctt 2188801 gtgtttgacc aagaactgaa ggacttgatg gaaaaagatg tacagcaatc cattcaagac 2188861 cttactgaat tacaagcggt ttatgagcgt gcctcatttc aggcccctgt ccctcaaagc 2188921 cgcccaacgc caatcatcaa ttgaaaggga ggtaagcctc tttgaataat gatcatttag 2188981 accccattaa ttcgctgaat gtgcctgaac tagcagacac tacattcgcg atggattttc 2189041 ttatacgagc taaggaaggc gtaaggaata ctgctgtagc tttgacagaa accgcttcac 2189101 cagatgtaag agcactgctt cggaaacagc tgatgcaagg aattgcgatg caccaagaga 2189161 ttacggaact gatgatcagc aaaaagtggt tccatccata tgagctgagc gaacagtata 2189221 agctggatca gctctctgca aaaaacacga tcatggtcgg caatatgaac ctctttcctg 2189281 atgaaacaaa tcgcaaaggg atgtttgacc ggacacctga tgaacactaa cactggaggt 2189341 tttacagcat gaaggcagta acgtatcaag gcattaaaaa tgttgttgtc aaagatgtcc 2189401 ccgatccaaa gattgaaaaa tccgatgaca tgattatcaa agtcaccagt acagccattt 2189461 gcggatcaga tttacattta atccatggat tcattccgaa tatgcaagaa gactatgtca 2189521 tcggccatga accgatggga atcgtcgaag aagttggttc tggggtgact aaactaaaaa 2189581 agggagatcg ggtaattatt ccctttaata tagcatgcgg ggaatgcttt ttttgtaaaa 2189641 accagctgga aagccaatgt gatcagtcta atgacaatgg ggaaatgggt gcttatttcg 2189701 gctattcagg gcaaactggc ggttatccag gcgggcaagc tgaatattta agagtgccgt 2189761 ttgcgaattt tacccatttt aaaatccctg aatcttgtga ggaacccgat gagaaattaa 2189821 gcgtgattgc cgatgccatg accaccggct tttggagtgt ggataatgcc ggcgtaaaaa 2189881 aaggcgatac agttatcgtt ctcggctgcg gaccagtcgg cctgtttgct caaaagtttt 2189941 gttggctaaa aggcgcaaaa cgcgtcatag cagttgacta tgtaaactat cgcttacagc 2190001 atgcgaaacg tacaaacaaa gtagaaatcg ttaattttga agaccatgag aatacaggga 2190061 attatttaaa ggaaatcacg aaaggcggag cggatgtagt cattgacgct gttgggatgg 2190121 atggtaaaat gagcgatctc gagttccttg ccagcggctt aaagcttcat ggcggaacga 2190181 tgagtgcatt ggtcattgct tcccaagctg ttcgcaaagg aggaaccata caaattacag 2190241 gtgtgtatgg aggcagatat aacggttttc cgttaggaga tattatgcag cgaaacgtca 2190301 atatacgctc tggacaggct ccagtgatcc actatatgcc gtacatgttt gaactagtat 2190361 cgacaggcaa aattgatccg ggagatgttg tcagccatgt cctgccgctt agtgaagcca 2190421 agcatggcta tgacattttt gattcaaaaa tggatgattg tatcaaagtt gtgttaaagc 2190481 cttaaaaaac ggaggttaca gaaatggaat acgccttaca cgaagtgctt gaggttcagg 2190541 aaatgactgc atttaagaca ctttgtttga cgaaatctaa aacaatgaaa gcactggtat 2190601 ctgatccgaa gctgaaagaa atcatgcagc aagatgttga tatcaccaca cgccagttgc 2190661 aggaatttgc ctctatttta tctaatgcaa agcaagaatg aggagatgaa taaatcatga 2190721 atcctatcat agaatatctg actggcatga atgttctaac agaccaaatc attgctatgg 2190781 acttattaat ttcagcaaag aacggagtca gaaattatgc gatggcagcc actgaagccg 2190841 gaacgcctga agtaaaagag gtccttatcc gccatttgga agaagcactc gatatgcacg 2190901 aacaactctc aagctatatg atggaaaaag gctggtacca tccttggaac cctgacgaac 2190961 aagtcaagct gaatttaaaa aatattgata cagccattca attgccaacc ctttaacata 2191021 caatgactga tttgctgagg aacagtattg attggccaca actgttcctc agcttcaaaa 2191081 tgagcactgt ttgttcgggt cctatgaccg taaatagatt aaccgctttt ctccatctga 2191141 tctccgataa tgtttgcaaa ttctccaatc caaataagga atcgtaacca cctcttttta 2191201 tgcgatctct tgatggagaa aacaggccag aaacaaaatc cttcgttttt gacctgccct 2191261 cttcacacgc aaagaatgct accttctttg ctccactgat ccgtgaagac tttccgtttt 2191321 aggcctgctt ttgagctttg cctcattttc acgcaatttc ccatcataat ctttaatttt 2191381 tgtgtctaat ctcttaattg tttcatcaat ttctttccgc ttctctatca gccgctgtcg 2191441 ttcgtcagcc aggatatttt ttcgagcttc taccgtacgg tcaccttcgg taaataatgt 2191501 tgtatattca attagcgctt ctatcgatag tcccgcattt cgcatgcatt taatgaattc 2191561 aatccatttg atatcttctt catcatagtc gcgaatgccg ctgtcttttc gttttacagg 2191621 cgggattaat cctacacgtt cgtaatatcg gagtgttgcg gctgtcaggc caaactgctt 2191681 tgccacctga gcaatattca tgatcttcac ctctctatcc tgtatgttgt gaaggtaaca 2191741 cttaaagtta actttaagtc aagctcaaaa caagtggtta gctgctgaat ctgggtttat 2191801 atattcggga cttgccttaa agcacacttt aaactctata cttctccatg cactaaaaac 2191861 agtgtagttg gagggattgc tgaatggcaa ataaacacac tgccggaaga gaacaattag 2191921 gagaatttgc gccaaagttt gctgaacttc atgatgatgt tctattcggt gacatttggg 2191981 caagagaaga agaactttca tcccgggatc gcagcatgat tacagtttct gcattaatta 2192041 ctgactgttt ctcagcttat aaatcaggtt cattttaaat ggttttttta aaaaaccctt 2192101 gccttaaagc agactttaag gtttatcgtt atgttgaaga caccataaaa cataaataag 2192161 tgcatgtttt tatttacaac acttatgatg aagaaaggat aggttcgtat gtgtaatcaa 2192221 catcaaaccc gtgtattaag cgtgtcacat gcaaaagcca aatttgaaca aacgacgatt 2192281 gagcgaagag gattacggcc gcacgatgtc ttaatcgata ttaaattcag cggcatttgc 2192341 cattcagaca ttcatagcgc ttttgatgaa tggggcggtg gcatcttccc aatggtgcct 2192401 ggacatgaaa tagccggtgt tgtaacagcc gttggaacaa aagtcaccaa gttggctgtc 2192461 ggggaccgcg ttggtgtcgg ctgttttgtt gactcttgcg gagaatgcga atactgtctc 2192521 aacgcagagg aacaattctg cacgaagggt gttgttcaaa cgtataactc agtagactac 2192581 gacggaaacc ccacttatgg cgggtacagc caaaaaatcg ttgtcactga cagatttgtt 2192641 gttcgcatac cagatcgttt ggaaatggat gttgccagtc cgctgttgtg tgcaggtatc 2192701 acaacgtatt ccccgctgaa acactggaat gttggccctg gtaaaaaggt tgcgattgta 2192761 ggcgtaggtg gccttggaca tttggcaatt caatttgcac atgcgatggg tgcagaagta 2192821 accgtcctga gccgttccat gaataagaaa gaggaagctc tggaactcgg tgcaaatcat 2192881 tactttgcaa caagtgaccc agccacattc actgcattgg ccgggcgttt tgacgtgatc 2192941 ttaaatacgg tatcggcaaa tctcgatgta gatgcctatt tatcaatgct tcgtatagac 2193001 gggacacttg taagcgttgg agctcctgcc aagccggaca catacagtgt gttttcccta 2193061 atcatggggc gccgcagcat tgcaggttct ctagtcggcg gaattcaaga aactcaagag 2193121 atgctggatt tcgcagctga gcatggcatc gaacctaaaa tcgaagtcat cggagctgac 2193181 caagtggacg aggcatacga acgtatcctc cgaagcgatg tccgttatcg atttgtgatt 2193241 gatatttcca cattgtaata ggttagtcct tatatgggct gccgctttta ttgaaactca 2193301 cgaaaaatga tctctttaag caaatatttt gaaggccggt caatcttcct gttattctat 2193361 gaatagagag ttattaggag ggttttttat gagcaaaaaa attgcagttc ttgttacaga 2193421 ccaattcgaa gacatcgaat atacaagtcc ggtaaaagca tacgaagaag ctggctacag 2193481 tgttgtggct atcgatttgg aagccggcaa agaagttacc ggtaagcatg gcgagaaagt 2193541 aaagattgac aaagccatct ctgatgtgga tgcaagtgac tttgatgcac ttttaattcc 2193601 tgggggattc tctccggatt tgcttcgtgc agatgaccgt ccgggtgaat tcgcaaaagc 2193661 atttgtcgaa aacaaaaaac ctgttttcgc aatttgccac ggcccgcaag tactgattga 2193721 tacggatctt ctaaaaggca aagatatcac aggctaccgc agcatccgca aagatttaat 2193781 caatgccggt gcaaactaca aagatgcaga agtagtcgtc agccacaaca ttgtcacaag 2193841 cagaacacct gatgatttgg aagcatttaa ccgcgaatct ttaaacttgt taaaataaca 2193901 agaaggcaca gactgttcgg gtctgtgcct tttttaaaat taagactcct tcgttacatt 2193961 ctgaaagaca gcagtcgcgt cccacacatt caagccaaat tggccttctg aaaatacgga 2194021 atcatgtgca tcaatcacaa gacgatcatc taaatagatt ttaaagcgat cgccctcggc 2194081 ctctgttttc agatgatact ttttattaac gtctatcggt gttttgtatt cagcaatgac 2194141 agaagcagca ccgttctcaa atttaaagaa tttcactagg tcatgcttcg catccacatt 2194201 ggcaaggtaa ccgtttttgg catctttgtc agagcgaaac attagtgctc ctgcccctct 2194261 tccgtttcca tccttaatgg tgatatcaga ttcataagtg aagtctgacc cggatgctga 2194321 agacaagata aaggaatcgc cgtccgacct cccttgtttc ccctcaattg tgtctgccca 2194381 cgtgccattt acagtcgtcc agccagtcat attggacata aaaggtgtcg ttccccatac 2194441 cttttttaaa gggtgtatcg ttaaagattt tacctttaca ccgccatttg cagcatataa 2194501 ttcaagccct ttgcttgatc ggtctgggag aataatatcc gttatgacct gctttccgtc 2194561 attcccaaat acttcaaccg aggagcggtc aacaaaaatg cgcaacttaa ccttcccatt 2194621 taccggcttc aacggggctg tttcttttcc ggtgttaaag gccggattaa aggtgtcgtt 2194681 gcctgactcg ctccggtcaa cgaacaattt ggcgttcctt cggtcatagc cgaccttcgt 2194741 aaattgattt tcacctgttc ggaccttaaa accaaattca gcagctgaac cagggcttac 2194801 tttaaattct gcatttattt cataggcatc tccagattgc cccgctaaca cattatgact 2194861 tgcaggcgat atggtcagat tcttccactt cttagaggtt ccgcgaatgg tttccagctc 2194921 tttcaccggt gtttggacca ctctaacccc ttcggtaaac gctttcaatt ttaactctct 2194981 tggaatggac gttgcacttc tccatgggga tgtcggaaca tcattcgcat attgccaatt 2195041 gctcatccac cctaaccata gccggcggct gtctgtggat ggaatatcag accaggatac 2195101 agccgcataa aagtctctgc cgtaatccgt ccagagaact ttgtttggcg ggttttcatt 2195161 tttaaaatga gttccatcaa agtcccctac aaaatattgc atgcctgatc ctcccgagac 2195221 cgctccgttt ccgacactga cctgcatgac ccatttcttt tgattcggat tgccgtctac 2195281 cggaagctca aataaatccg ggcattccca tactcccccg tggcttcctt gatcctgtcc 2195341 aaattcactt gcatacgtcc actgcttcag attttttgat gtataaatga ggattcggtc 2195401 accggccgca agcaccatca cccacttttt ttctttctca taccaaaaga cttttggatc 2195461 gcgaaaatct tttttacccg ggtttggaat gacagggttg ccagcgtact tcgtccatgt 2195521 tcttcctttg tcgttgctat aggcaatact ttgcacttga tggccttccc gatcctgtgt 2195581 ataaatggcc acaagcggct tctctttgcc tgtttgaaaa ccgcttgtgt tatttttatc 2195641 tacaactgcg cttccagaaa agatcgtgcc tttttcatcc ggatacagcg caacaggaag 2195701 gtgttcccat gtaaccaaat ctttgctgac ggcatgcccc caatgcatgg gcccccactg 2195761 aagcccgtat ggatggtatt gatagaacaa gtgatattcc ccagcataat ataccattcc 2195821 gtttgggtca ttcatccagt ttgcctccgg tgtgaagtga tattgaggac ggtaatcctc 2195881 atcatagtag cttgaatcgg ctgcatctgc cgaaaatgcc atagtcaaca gcagggtgaa 2195941 catgatcatg acttgaatca gtctcttttt catttgttcc ttcgctcctc tcttcatgtt 2196001 tgaacacttt caaaagagac tgctgcgcaa gctggtccgt ttctggcaat tctcctctgt 2196061 ttcactgtta tccgaatgat ttatatatga aaagactgct gcagtttctc tctctttcct 2196121 tcacacacct tatgctaaga atccagccca atacccgaga atcccgatga caaagatgcc 2196181 gcaaataatg agaagtggat tcaccccttt gcgaagcatc catgccacca ataacgttaa 2196241 tccgagaggc agcgcccccg gcataatgct atctagcacg ttttgtaccg tttgaacatc 2196301 tacttttccg ctttcatcct taatcctgga tacaacgatt ggaatgttga tggtggtcca 2196361 tttggacacg agagccccca taacaaataa cccgagaatc gaagcgccct ctgtaagctt 2196421 ttgaatgcga ttccccgcta aatcctgaag aatctccatt cctttcacat agccatactt 2196481 taatccgtaa tattttgtgc ttaatcttat ggcattcagc aagaaaaaga atagcaaagg 2196541 accggcaatg tttcctccta aagcaaggga ggctcctagc gcagctaaga caggacgaat 2196601 cgttccccaa aaaattggat cgcctacgcc cgctattggt cccatcaaac cgattttcat 2196661 tccgcttatc gcttttccgt caattccttt attgttcgcc atttcttctt ccatggctgc 2196721 cgtcacgcca aatataggcg ctgtcagcca cggatgtgta ttaaaccatt ccaaatgccg 2196781 ctgtaaggct tcgtttcttt tcgctccggg accgtacaat tttttgatcg ccggtatcat 2196841 gacataacaa tatcccattg cctgcacacg ttcgaagtta aaggaaccga gtaaaaaatt 2196901 tgaacgaata aacatgctga aaatttcttt cttcgttaat cgtttttctt tctccatttt 2196961 ttcttccccc tcatcgttta ggcatcaaga tcatcatcat cgtcatcata aacagcaaca 2197021 ctgccactgt ctgatgcggc cgcgactgct ccgtgagcgc tttgtttttg catcacctgc 2197081 tggtataaaa gcgccagaca gagaccaagg gctccaaatc ccactaagtt aaaatcggta 2197141 aacgccgcta ataagaaacc aatatagaaa aatggcttta aataaggaat attcatcata 2197201 ttgatcacca tggcataccc gacaaccaca ataatgcctc cgcctatttg cagtcctttt 2197261 gtaatgacat caggaatatt tcccaggaac gcctgaacag cgctgacact aattaaagca 2197321 acaatcaatg taggaatcat gacgcgcaaa gcttgaaaca ccatcgcggt aatatgcata 2197381 atttcaattc cttttatatt tcccgctttt gcatattgat cagcgcggtg gatgaaaaag 2197441 acagtgatcg tccgaacaaa aatcgtcagc gcctgacccg cagctgctaa agcaacagcg 2197501 acagcaatcc cttcgccaat tccttgatca gcggtaataa ctaaaatggt tgagatgaca 2197561 gaggcgatcg ctgtatcagg tgccatggca agcccgacgt tcatccagcc gagcgccatc 2197621 agctccagtg tgcctccaag aataattccc gtttttaagt ccccgagcac caagccaacc 2197681 aacgtacagg ccactagcgg ccggtgtgtc tgcccttcat ccaatacact tgcgattccg 2197741 gtgattgctg caatgattaa caacaaaata atttgtaatg aagacatatt ctcatcccct 2197801 tgattatttt gttacgttcc gtaaaatctg tacaaaatcc tcactggcat ctgaaggcag 2197861 ctgcctcaat tccagtttca cgcccttgtc acttaatgtt tcaaatgcct ttatatcttg 2197921 ttctgtgaca ctgactgatt ttgtgatttg cctgcgatga ttttcaaaac gcattccccc 2197981 gacgtttacg gttttgatcg gtacacctgc ttctataaga gatacaatat cggacggatt 2198041 ttcaaacaag agcattgccg ttaccccttc gtagcgcgga ctatgaaatg cttttgccat 2198101 tttagaaacc gagacggcac tcgcctttac atttgaaggc gcaacagaaa ggatcagcgt 2198161 ttttctcatt tcgtcctgag caatatcgtc ggagacaacg atgattcggt cggctgcatg 2198221 gacttttatc caccttgtca ggatttggcc gtgaataaag cggtcatcaa ttcttgctaa 2198281 cacaatgttc atcataattc atcctctctt gtatcttgat tggctgtttt tactttttct 2198341 aaatgttcac tgcacacttg aaagctttgc tgactcattg cttttaagtt gttcagcaaa 2198401 tctttgagag ccagatgttc tctcaggctt aatacctcca gcagaatcgg caggtttacg 2198461 ccggcagcca tatccattct ttgatcctca gcaataaagg aagctgccgc gttatatggc 2198521 gtccctccaa aaatatcgac taaaaaaagc acttcatgtt cttccgggat atccttgagc 2198581 gcctgatgat atttttcttg cagcgtttgt attccttccc ctttgaaaaa cggcactgca 2198641 atcaggttat tttcttcacc gaatatcatc cctgaagact cttttaatgc tatgggaaaa 2198701 tctccatgac cgctgataat aactgaaatc atatctattg ctcctttcct gttttgtaca 2198761 tccatatata atgcaaggat cgtgccaaca cagttgtgtt aagcgttttc attgttattt 2198821 cagccaatag caatttgttg ttgaaacact taaaacgaaa aaaataaacc tgtattaaaa 2198881 tggtgttcca tttaatacag gttcatatga aaaaactgtt tttaaaacag ctggccatgc 2198941 acttcttcag caaatatggc ggctataaat aatttttcat catcacttat gcgaagtccg 2199001 agcttttctt cataaggggc taatgttcgc tctgtcacgt acaccatttc cttcagctga 2199061 tcattgatct cttcttcctc tgagaaagcg atcggattct gcttaattac cctttcaaag 2199121 gcgaaagccg tgtgcataat gactttgatc aaaaccgcat tattgaaaat gacccccagc 2199181 tcatcctgaa cggtttgcag ccactccaat aacatgtcga tcacatggtg gggattcaag 2199241 aagacaaggt attttttcag gctatcctcg caaagctccc tgacaataat atttgcttcg 2199301 ttcaatccat tgctcaagga gatgcttcct tttgtaatcg cctgttgaat cagcttctct 2199361 ccctcccctt caattaacac ttctaaagat acatgcggag cattgatttt agggtctttc 2199421 gttccgactg tcgcaaggat ttcatactct ttttcgattt cttttatgct gttggccagc 2199481 ttaatcgatg atacggtcaa tatgtgaatg ggggtatcgg aggccttgtt tacgatcgtg 2199541 gttagaatgt cttccagctt tttggccgtt ccgctacccg tcgtgcagat ggataccaat 2199601 gccttctttt tgccggatgc cgctggctga cgctcccaca actcgataaa atccttcgtg 2199661 accgattgat agatcgcatg caaatttaaa ttcaaatagt tgacctttct gacagcatcc 2199721 agcaccattg aagtcgtaac attgctgatc gttttaatag aaatgcctgt cttttcctcc 2199781 agcctgcttt ccagcattgc aagcgacccc atatctacca gcattaaaac accttcacct 2199841 tcatcaacct gtttcatttt ttctgctacg cattcaagaa tgtccgaagg tgaaacagta 2199901 agcggcatgt caactgctgc aatcggcgta ctccctagca gttctgtcgc gacttcaacc 2199961 attgaactcg ccgtgctgtt tccatgagct gccacgataa taccgactct tttgttctcc 2200021 tttaacgatt tgatggaatg aattaacatc gttaagtaga tgacttctat ttcaggaata 2200081 gccactttaa aatattcctg aattttatct ttaaaaatca tcgccacccg atattctttc 2200141 acatgggtat cacgaatttc atctgtctcc tgtgtattca aaacatcaat ttgctttcct 2200201 cgctttaaaa atgcgtcaat atgcatactc aagaaataaa taaacttacg gtcaaatgtg 2200261 caatccagct catgttcagc tatttctttt aactgttttg tcatttgaat cacatcgtct 2200321 tcaacgaatg tcagcaggtt gtctttttga aaagcttgat gatgaaaaaa acttctgaca 2200381 tgcaaatgga catcagtcaa gatgtactgg ttaatatcct ttttggataa accttctttc 2200441 ataagcgttt tcactttttc ctcaatcaaa tgatataagt taaatgagag gtcttcgtca 2200501 atttttgttg tttcatcttc tacaatcgga gagataatcg ttgtaatatt gacatattca 2200561 gaaatggctt tgcttctttg catgtttttg ctgctggaca tccattcttg cttgatttca 2200621 tcaggcagat cgcgaacagt cagttcaata acttcatttc tgtcaaggtt atgcaaaaat 2200681 ccgtgtgcgc aaactaactg aacatttgat ttcagctgtc cgacattccc aaatttcgca 2200741 gagtgaataa gcgcattata gacatcgata tgcacactca gattcttctt aattcgctct 2200801 gcttctttcc ctaataaaaa cgtcgtcaga tccactcttt cattaagcga tcgttcttca 2200861 agcgaaggaa tatgaatggt cattgggatt cttcgcaaaa acgttttcaa tagtgcagaa 2200921 ctcggatttt ctgtagtcgc acaaataaac aatacgttcg atgttcgttt atgttcagat 2200981 tctccaagcc tgttataaga accgctgtca ataaaataaa acagcatttc ttgtccctcg 2201041 ggagggagac ggtggatttc atccataaaa agaatgcccc cattggcctg ttcgactaaa 2201101 cccgccttat cctcggcagc acctgtaaat gaaccttttt tgtgtccgaa taattgagaa 2201161 agcaataatt gagggttgtt gtagtagtct gcacagttaa atgtaataaa tggtgcgccg 2201221 gccttcaata tgtcagagta aatggcaaac tggtaaattc ggttcgcaaa aagggattta 2201281 ccggaaccag tcggccctag gaggagcata tgcagaccgt tcggcggata aaagacagct 2201341 gcttttgcct gggagatcgc tttcttcaaa ctcccttttg cccctatcat aagctctagg 2201401 ggattcgtgg aaatgtgttg atgattttgc tttgaatttc cggaaaacgc ctgaaggtct 2201461 ttcacttcca tcatctctgt atcccatttc ttgttgaata atttttctgc tatctcgact 2201521 gggatgtatc ttacaggaaa tgttttaatt ttgatgacct ttttggaccg gacgagattg 2201581 ttcaattcaa agctgacatt ggaccgctcc attttcagct gctcggcaat ctcctttgct 2201641 gaattccctt gtatttttaa aagatgatct aaggttgaat catgaaaatt atgcttgagc 2201701 tgatggtata ttttatctat tcttctcacg tctatcatcc tttgtcctta ttagataagc 2201761 cattaacaag aatatttcga aactttatag tccgcgttga gatttacacg tttaaaaagg 2201821 tctctatagc agattgacaa agctggcttt tatgcgtata tgtttacatg ttgaatcatt 2201881 tgcacctcat attagtatga tagatgctca gttctggagg gccagtcccc ttcaaaagta 2201941 ataatcagta aacagtttat cattctcggg gaatgtaatg atgtcaaaat aatcaatgac 2202001 aaaaaatgaa tcttatagat catgacaaat tacccaaata taacccctta agttcgttca 2202061 caactaaaaa gacggacact ctatgtgacc gccacagtat tacaatttgc aaaacttcgt 2202121 catttttgca atccacattg gaggttaagg aatctgtaag cttaaaaact ttatctccga 2202181 tcctatcgat ttgatccccc tgccggcctc aatcatagtg ggtatgcaat tatacaaatc 2202241 gttaccgatt aaaactagcc tgtcagattg tccaaatgac tttcctgttt tactctgcta 2202301 ttcaggtaga atcacgagtg aaaaatagag ccacaagaca tgtaacagca cttaaaatag 2202361 ttttaaaatt taaaaataaa agtatctatt cttttaaatg ttataatatc cgataaaact 2202421 ttactcatct ttttattact ggaggaaaat aaaattgata ggcaattcta gcaaagacaa 2202481 ttttggccag caacagaaat tgtctagagg ccttaaaaac aggcatatac aattaatggc 2202541 gattggaggt gcaatcggta caggtttatt tttaggttca ggtaaatcca tccattttgc 2202601 aggaccatcc attttatttg cttacttgat caccggcgta ttttgctttt tcattatgcg 2202661 ttcgctcgga gaactgctct tatcaaatgc gggataccac tcttttgttg attttgtaag 2202721 ggactattta ggaaacatgg cagcatttat cactgggtgg acctactggt tctgttggat 2202781 ttccctcgcg atggctgatt taacggcggt cggcatttat acgcaatatt ggcttcccga 2202841 tgtgcctcaa tggctgccgg gtcttcttgc gcttattatc ctgctgatca tgaaccttgc 2202901 caccgttaaa cttttcggag aattagaatt ttggtttgca ttgatcaaag tcattgccat 2202961 actggctctg atcgtaactg gtattctcct gattgcgaaa ggtttttccg cagcttccgg 2203021 ccctgccagc ctcaacaacc tttggagcca cggcggcatg ttcccaaatg gatggcatgg 2203081 gtttatccta tctttccaaa tggtcgtctt cgctttcgtg ggtattgaac ttgttggact 2203141 gacagcaggt gaaacagaaa atccccaaaa agtgatccct aaagccatca atcaaattcc 2203201 tgtccggatt ttactttttt atgttggcgc acttttcgtg attatgtgta tctatccttg 2203261 gaatgtgttg aatccaaacg aaagcccatt tgttcaggtc ttctctgcag taggcatcgt 2203321 tgtggctgcc agtttgatca attttgttgt attaacatca gccgcatcag ctgcaaatag 2203381 cgctttattc agcacaagcc gaatggtcta ttcacttgca aaggatcatc acgcacctgg 2203441 actattaaag aaattaactt cttctaacgt gccaagcaat gcgctgttct tttcatccat 2203501 cgccattctg attggcgtta gtctgaatta tttaatgccc gagcaagtct tcacgctgat 2203561 tacaagtgtt tcaacaatat gcttcatttt tatttggggc atcacggtga tttgccattt 2203621 gaaatatcga aaaacaaggc agcatgaagc gaaagcaaac aaatttaaaa tgccttttta 2203681 cccattatcc aactatttaa cacttgcatt tctcgcgttc attcttgtca tattggcact 2203741 ggcgaatgat acacgtattg ctttgtttgt caccccggtc tggtttgttt tattgattat 2203801 tttgtataag gtgcaaaccc gcagaggaca taaggtgaaa taaaaaaaag acaagggata 2203861 ctcactccct tgtcttttta tatgtgtcaa acactaaatt aaactttggt ttcaaatttc 2203921 attcacttca tttaagtgtt aactcaaacc agttttgatg ccgaaaccta ctaatattat 2203981 tccggtaatt ttttgaaaca ctttctggaa cttcgagttt ttcatccatt tttttgcgta 2204041 atcaataata taaacaagaa acaggaacca caacaccgct aataaggtta ggattgaagc 2204101 taaaatgatg agctgctggt ttatatttcc gttcaaattg ataaattggg gcatgattgt 2204161 aacatacacc aaaacagttt taggattgag aatgttactg agtgatccct gcataaagga 2204221 agttttataa taacgtttcg gagaacttgc catatttttt gcttgggatt gcatgtcatc 2204281 taacgaaaac atacttttag caaaaaaact ttttacacct aaataaatta agtatgccgc 2204341 tcccaaatat ttgatcgttg tgaaaagaat cactgacttt gcgattacca ctgataatcc 2204401 taaaatggca atcaccgtcc aaaaggaaag tcctgtcgcc aatccgagaa tgttataacg 2204461 gccggctttc ggaccatacc taagcgtatt tttcatcaca agcatcgtat ctgcccccgg 2204521 tatgataacc atcatggcag cgatcggtat gtatgcgagt aagctgtgca ttgttctctc 2204581 cccctttaaa aatcccctca atcatatagt gactacaaaa gtaactactt ataaaagtgt 2204641 atcaatgcgt ttggaataaa tcaatatgat ttgttaaaat agcgattact aaggcagcga 2204701 ttgctcttta tattggagga tatatgaaag aaaatatgtt agacatttta aaaaacctca 2204761 attttacaga atatgaatcg aaagcgtatt tagcattatt gcaagaatca cctttaacag 2204821 gctatgccgt tgccaaaaaa tccggagtgc cccgttctaa aatttatgaa gtattggaaa 2204881 gtcttgtcat aaggggagat gtttttgtca gtcatggaaa tacgcctcag tatgttccag 2204941 tccccgcaaa agaactgatt aaaaaccgcc ggctcaaagc ggaagagcat tttgatcagg 2205001 ctgagaaata ttttgaaaag ttcgagcaga ccgcaaatga ccgggaaaac atctggaata 2205061 tcaccggccg cagtgaaatt cttgaaaagg tgaaggcttg tatcttatct gccaaaaaaa 2205121 gaatcctctt agaaatatgg aaagaggatt ttaaggagat agaagcagag ctcaaacagg 2205181 cggcagaaca aggcgttatt gtcaccatta ttgcgtacgg agacatcgta tctgattttg 2205241 ccaatgttta ccttcatgat atgagcagtg aaattacaga agagtatgac ggacggtggc 2205301 ttgtctatag cggagatgat tcagaagtag tagcgggcat tgtctcactt ggcaacgaca 2205361 gccgtgctgc atggacgatg catgtagggt tagtcatgcc tattactgaa gtgatcattc 2205421 atgatctgta cctcatggaa attctgaaaa agcatagaga gcttttagaa gagagcttcg 2205481 ggaaaaatct catccagttg cgccgtaaat tttctattca ctcagatttc aaaaaacatt 2205541 atttggaata atgtttgtca tctcttaccc caaaaacaag gcttgtacaa aacaagcctt 2205601 gtttttttat gcataaaccc cccatgctga tttacttctc tcttttaaaa aatgtgattc 2205661 tgcgcaaact atttttcagc ctgccgcgtc tatcctaggt aacagcctac gatatacgta 2205721 tattcaaaaa ggagcccttt attgcaatga agaaaaaaca aacaacaaaa gcgttgcttg 2205781 tcacatgcat aactgaccat aagcaagatt tctacaggtt ggctttcagt tatgtgaaaa 2205841 atcaagatga cgcattagat attgttcagg aatctataaa aaaagcgctg agctcagttg 2205901 aaacggtcag gaaccctgag acgataaaaa gctggtttta taaaatttta gtacggacag 2205961 ccattgactt tttgcgcaaa caaaaaaaga taagagtgat ggacgacgaa acgatagaat 2206021 ttttaagcaa aggaaaggaa gaccattaca aggatactga tctccatgaa gcgcttgacg 2206081 aattgccgta ccgctataaa accattatta ttttacgttt ttttgaagac ctcaaattag 2206141 aagaaattgc ggaaattaca ggagaaaaca cgaataccgt caaaacgcgc ctatacagag 2206201 cattgaagct gatgcgcatt cagttgacga aggaggatct ttcttaatgg ataagagatt 2206261 acagcaatta agagaagaat ataaaaatgt tcagattcct aaagaattgg atatcattgt 2206321 tgaaaaagcc cttcagcaag aaccaaaaaa gaaaagaatc gttatgtggc cgacatcagc 2206381 agcaatcgct gcagctattt tattcactgc gcttgttaat atcaacccgg acgccgctca 2206441 ggctatgtca aagatccctg tcatcggcaa aatcgtcaaa gcgatcacct ttattgaaat 2206501 caaagaggaa aaagaccaat caagcattga tgtcaaaaca cctgctttgt ccgggctttc 2206561 taataaagag cttgaaaaca gcattaacga gaaatacttg aaagaaagcc agcagctgta 2206621 taaagagttt atacagtcca catccaaaaa caaaaaaggg catctcagca tctacagtga 2206681 ttacgagacg gtcacagaca cgccagattt actctctatc cggcgcaata ttgaaacaac 2206741 acaagcatct tcctacacac aaagccgtta tattacaatt gacaaaaaga atgatatttt 2206801 acttacatta aaaagcttat tcaaagatga gcgctatatc aaagtcatca gtcaaaacat 2206861 caaagaacaa atgaaacagc aaatgaagga agatccaaat aaaatatatt ggctcactga 2206921 cgaagatgca gaaccgttca aaacgattct tcctgatcag acgttttaca ttactgaaga 2206981 ccataaactt gtgatctcat ttgacgaata tgaagtcgcc cccggctata tgggcgttac 2207041 agagtttaca attccaaccg gcgtcatttc aaacttgctc gtgggagaac gttatattcg 2207101 ataaaataaa aacatccatc taagattatg gatgttttct ctcttctcta ttcgaggtcg 2207161 taaccccgct atcaaaaaca acgagaatat ttgcatacta ttggaggaat acccatgtat 2207221 cacaagacac agcatcatcg atacattcct ggacttgatg gccttcgggc tttcgccgtc 2207281 ctgtcagtta tcacttatca cctaaatttc aattgggcta acggtggttt tatcggggtt 2207341 gatatctttt ttgttttatc cggatatttg attacatcta ttctattacc ggcatatgga 2207401 aatgatatca atcttgattt tcgggatttt tgggtgcgcc gcattcggcg gcttctcccg 2207461 gcagcgtacc ttatgatctt ttccactgtt gtgtgggtcg tattgtttga tcgagaacta 2207521 ttgcacactg tacgtggaga tgcgatctct tctctctttt atatgagcaa ttggtggttt 2207581 atttttcaca agctatcata ttttgatagt ttcggttccc catcacctct aaaaaacctt 2207641 tggtcgctgg cgattgaaga acaattttat atcatatggc cgatgttttt agttgttgga 2207701 atgtacataa tgaaaagccg cgccagattg gctgcggtga tatcattgct tgtgctttgt 2207761 tcagccgtga tgatgagcgt actgtatgaa cctggcggag atccgagccg cgtttactat 2207821 ggcacagaca ctcgttcgtt tgaacttctc atcggatgtg ccttggcttt ggtatggccg 2207881 atgaaaaggc tgtcttccaa caggctgcca agcaaactga agcacacttt gcacgccact 2207941 gaatttttgg cattttgtat tttagtgttg tgtgtctatt tcacagatga atacgagcct 2208001 tttctttaca gaggcggaat gctattcatt agcgtgactg ccgcaatcct tattgcatgt 2208061 gtttgccatc cgagcagctt tttaggcaat ctgctttcat ggaggccgct tcggtggctt 2208121 ggaacgaggt cttacggaat ttatctttgg cactaccctg ttattgtgtt aagcacgcca 2208181 gttcaagaaa tcggaaaccc tgttttttgg catatcgtgc taaaggtcat tgtgacatgt 2208241 atacttgccg agctctccta ccattttatt gagaagccga tacggacaca gggatttagg 2208301 tcattttccc gccgtgtttt tatacataga atcaaggaat ggaaaacgac atctgtcatc 2208361 agcaaaatgt caattggttt cattattttc gctatactta tttttgcagg cgggctgtca 2208421 gggctagccg gcgagcaaaa gcaccctacc aaatggacct atagctcaca agaaacaaat 2208481 gctgacacca gccaggcttc tggggataaa aagaacgctg cagcagataa aaaacacaat 2208541 cctgaacaaa agacaacaga ttccaatcag ggtcaaaagg aaaacaaaga tagtgggcaa 2208601 gagactcata aaaagaaaga cacgcaatcc caacagttga aaaaaccagc agacactgcg 2208661 aaagaagttt tagctatagg agattccgtc atgcttgata tttcttcaca cctgcgtcag 2208721 tcattttcaa atgtgacgat tgatggaaag gtagggagac aaatgtctca agctttggaa 2208781 ctcgcaaggg aatacaagtc ttttaatcag ccgaacaagg ctgtcatcat tgagcttgga 2208841 accaatggct attttacaaa cagccaaatc gaacaactgc ttcaatcttt ctcaaaagct 2208901 catatttatc ttgtcaatac acgggttccc cgccaatggg aaagcaaggt aaatgaatct 2208961 ttgcagcaac aggcccacgc acatcaaaat gttacgttag ttgactggca tacagaagct 2209021 cttcagcatc cggaatattt tacccctgat ggtgttcact tggttcctaa aggggcaaaa 2209081 actttgactg ctcttattgt tcaggcgatg aaatcgtaaa aaagagatcc tatacagatc 2209141 acttttttac tttagtttct gatcgttgat tatgtcttct ttcagcaagg cagcccttat 2209201 gtttacatgc cgtttacgta agggtaagcc aaaattgaat ggagggatga taatgaaagg 2209261 aaatgaagaa catgacatcc aaaaagagtt gaaacgatat gagctttttt tcaaaaaacg 2209321 atataaggtt ctttatacag taaacgattt tatcatcggt gctatgtttc tcgttggaag 2209381 ttttttcttt ttttatgacc ggttaatgtc ggcagggata tggctgtttg cgatcggaag 2209441 tttgctgctg ttaatcaggc cgaccattcg gctgattcat gactttcatt accgtaagca 2209501 tgtggaacag caattcaagc atcaatcttc aacagatgac tgatcttaag gaataagaaa 2209561 gaacaaaatg ccaaaagcct gagtcgaaaa tcaaaaacaa gactttcaga ctatttattt 2209621 ttaaaaacaa ggtaaaaaga actaaacttt tgcctctgca tgccgatatg aataataagg 2209681 ccggcgcgat actccctata acatcctttt cagtagattt cattatcgtg ccggttttct 2209741 catatgcaaa gcaatcccgc caatcagatt ggcgggattt tatattttac attcctgtcc 2209801 aaacgtcttt cacataacgt ctttgatctt gcagcttttg cagccataca gctgattctt 2209861 cctgacttgc tgctttttca gcttcatatg ccaatcgcaa agttctctct acatcaggag 2209921 ccatttgcga tccatcaccg catacgtaaa tatgagcccc tttttcaatg agtgtcatca 2209981 atttctgcgt atcttgcttg agcaagtgct ggacatatcc ttttggttcg ttttcgacgc 2210041 gcgagtagca tcggcggatt gtgaccaaac cgtcctgttc cgcttgatcc agctcttctc 2210101 tgtaaaggtc gtcatggtcc gggcggcggc agccgaagta taaaagtgct tcaccaaggg 2210161 tgcttccttc cttcttcaaa accgatcttg cctgaataaa gcctctgaat ggcgcaattc 2210221 ctgtgcccgg cccgaccata atcataggcg tttcaggatc attcggcatc tgaaatccgg 2210281 actgcggcgt acgaatgaag caagctgctg catcacctgt attcaattct gctaaataat 2210341 tagaggcgac accccggtat tcacctcggc cgctccatgc tgaggctttc acaactccta 2210401 ccgtcatgct cacgatattt gcatgaactt tcggtgagct tgaaatggaa tagtatctcg 2210461 gttttagtga tggcaaaagt gctaaaaacc gttcaaacgg catttcgcaa gcaggataat 2210521 cctctaaaaa atcaagcatg gtaagacgtt ttgcaagtac ctgctctttg taaatgccat 2210581 catctgaaac gagctgttcc agctcttttt gatgcggcgg acaaactgta taagaggcca 2210641 gctcccgaag ctgaagcctt gatgccggtt cctgcagctc tacataggac gacaataaat 2210701 ccactacttt gattggccga tccatcggca gatgagccat atgagcgctt ccgcttactt 2210761 ttatcacatg attggactgc aaaccgaatc ggctgagaac ccgctgaaca agctccctgc 2210821 tgttctttgg caggattccg atatgatcgc cttctttata tgttttacca gccggaattt 2210881 ccaattcaat atggcgggtt gaacgcgtgc tggcagctgt ctggagttct cgattctcta 2210941 acacaatccc ttcaaacgcg ccatatgctt tagcaaccgg cgtttccgtc gcttcactga 2211001 gaaaagtaat cgataatgaa ggcctgtctt ctttctgggc tatttcgtta atatcaaatg 2211061 cgtccatcgt ttccttccag aagcggtttt cccaagactc gcggtggctt tcaaaatcat 2211121 cggcggcgtc accttcccca atcgctgtta aacgcgatgc cccctttgct ttcatcatgt 2211181 catcaatcag gcggggaatc cgctgatacg tgctggccca gctccggttt ccgcagccga 2211241 ataccgcata ggaaacacct ttcaattggc cttcctcaag ctctttcagc cactctacaa 2211301 atccggcagc attatcaggc ggcgccccat tataagaagc cgttacaatg acgactgccc 2211361 cttcttcagg gagcttgccg atataatcat caagcggagc cgtttcagct gtaaagccca 2211421 tctggcggcc ttgagcagcc agttcaccgg ctattccctc agctgtccca agatttgaac 2211481 caaaaagaac aagtaaaggt gtgccgtgtt taggtttggt ttcttttggc tttgtttctg 2211541 ctttgatgtc tgcctgttct tttctctgta cattgattgc cgctgttttt cgcggtttca 2211601 cagtaatttt aaaatcatcc ggcttgatcg ttaatgcttc tttgattttt agttcgtagc 2211661 cagtatggtt tatcaattca aaatgcttta atacaagacc gagaaccatt gtcgcttctt 2211721 gaagagcaaa ctgcatgcca atacaagcgc gctgtccgtt tccaaacggc ttatacgcat 2211781 ggtgagggat acttgaagga tcctcaaacc gttccggacg gaaatcttcc gcatccggtc 2211841 cccaagcgtt ttgatcccgg tgcagttttg gaattaaaac agtgactggc tgccctttgc 2211901 tgatcggata ttccccgcct agaacagtat cctccttcgc atatagagaa aaagccggag 2211961 ctgttggata cagtctgagg gtttcattta aaaccatccg aatgtatttg agctgctgga 2212021 tttgtttata ttcaggcgtg tcatccgtta acacgcgatc cgcttcctcc tgagcttttt 2212081 tcagtttttc cggatgtgta agcagacaat aaatcgcaaa ggatagcaac ccgcttgttg 2212141 tctcatgtcc agcaattaaa aatgtgatga tttggtatcg aatgttttcg tcatccagcg 2212201 tttcacccgt tactggatct ttggcataaa gcatgagaga caagagatcc ttaatgtttt 2212261 catccggatt cgcctttcgc tccgctatca ttctatcaac cagggagttc atgacttcta 2212321 tatccttttg gaactgcagc ttcgttttca ccatcatttt atcttgcagg cccagtcttt 2212381 tcgattgatt catcgcctct tttaaggcac ggagcatact ggtgataaac ggatgctgtg 2212441 aatcacggta aaagctgttg aatcgatagt taaacccgca taacccaatc gtatcaagcg 2212501 tcagacgtgt catatcgtcc gctacatcaa tttcttcatt agggtttaac cggctccact 2212561 tttgaatcag ctgggttgcg atatccagca tcatagaatg atagcctttc atcgcttttt 2212621 gactaaaact cggcagcaaa atgcggtggg ctttttgcca gttcggttcg tgcgtccagc 2212681 ttgtaaataa gccatctccc ccgaactcac gcaccttttg caagcctttg ccaaggttct 2212741 tgtcaaagcg tttttcatca cacacttcag ccacaagatt gtggccggac acaaaaacac 2212801 tggatactcc cggaaaatca aaacggaaaa tcggtcccaa ttcatcagct atccgccata 2212861 aggattgaga aagctgttct ttttccagat gcggaagatt ttttaaaggt ccgtatgttt 2212921 tgggctgagg tattgcgctt gcctgtttca ttaacatctc cctttcctat ttttgtgatg 2212981 aatgaagctt aatggcgtcc cagcagcatt gttccaattc agtaattaaa tcagtgtcca 2213041 tctctatatc acctgtttga acgagctgat atatcttgag aaacgcccct aatacaatcg 2213101 caattaacac attagagggc aggctgcgaa tcacgccttc cgcttttccc ttattaaaat 2213161 agtcatcaag catttgagtc agattttcta tcattttttt gcttgtatga tttaagtaat 2213221 gagcgtcttt tttggtttca agaaaaaaaa gcgcatagtc gctctctttc gtaaactgaa 2213281 cgagacagca aaatacgtgg tgaaagcctt ctctgacagg caattctgaa acgtcttgct 2213341 tcagtttttc cgtaaatcgc tggatgcttt cttgaaacag tacgttaacg agtgtttctt 2213401 tgctgtcaaa ataacgatag atcgttcctg tccctacatg agcacgttca gctatcatag 2213461 gaatagtggt agcgtcaaaa cccctttccg taaaaagtga gactgacgct ttcataatca 2213521 tgtcgtattt actgctggat gcggatatca tgtaatctga caacctccga ttcgtttacg 2213581 gaatgaatat tcattccttt tgttcacaaa gaatgtctgc cctgtctgat atcacctctt 2213641 tgttctttct tctgttataa gtttatatga aaaaaacttt ttttaatata aagtatatgc 2213701 aaaaaataaa aaattaagaa aatataccca aatcctaata cgaggatctt ggatatattt 2213761 cccgagaaat tttttattta acagccacaa tacatagaca ggaagcacgc ctgataacag 2213821 aaagatccct gaaatgctgg tctttcagca gttgaatata cgttttctct ttttcaccgg 2213881 tatttgtgtc aatactgata taaaaccggc cgtcaatttg aagcaccctg taaatttctc 2213941 ttaatgcaag cctaatatcg gtgcagcttt gaaccgtatg taaagaaaag actttattaa 2214001 aggtacggtc atcaaaggga atgtcctctg gatagccatg aaaaacctcc ccgttcccca 2214061 tgttctttcg attcgcacgt gatatctgtc ttacctttcg ttttgaagga tcaatgcttt 2214121 ttaggctacc cttttttagt ttcttggtta tgcttttaaa gacagtgccg tttccaattc 2214181 caatttctaa aattctgtca ttttcttgta tatctataga gtcaatcatc atatgctcaa 2214241 ttgttttggt tagcttatat ttccgagaaa ataatttcca aaaatccgat cgtttataga 2214301 gtctattttc tagcatttta aacacctgct tttggtttcc tatgtttatt tattatctta 2214361 aaaaaataaa catcatcttc atttctaaaa gtgaaggaag gtaccaacta gacggcaatg 2214421 tattgaaaaa tgtttcaata gaactaaact ttttcatttt tttccgaaaa aaaagcagaa 2214481 aacataatgt tttctgccct ctttctaatg ccaatgataa gggaatacat acagcctttg 2214541 ctgctgcatt gccatcagcc tctgctgtcg gaatggattt ccataaccat gtttgaagga 2214601 atgcggcatg gacgcataac catggccaat cgacggcagt cttttttgat aatcgttcat 2214661 catgccatca cctgcctcac aataacgttg atttactata tgcaggcgcg cattttcttg 2214721 acagctattt cgctaaactt ggtccttctc cattgtataa tgcatcaata gttccattct 2214781 aagcatatgc cattccccct tcagtttttt tcgttgcttt tagcgccagt ttgttaaata 2214841 aagatgcttt aactgagact ctttcatttc atcataaatt tgttcaatct gctgttctcg 2214901 ttcgaattct tccaggcttt taaaccgttt tttaatcgtt aacgttaaaa agaataggtt 2214961 aatcgtcata tcgctcaccc cctttcaaag tccgcatcaa gcgaaataac ccgcggcaca 2215021 acccttctgc cgcgggcaaa taaaaaccgc agacaaaaga agacaccaat gcctctactg 2215081 cctgcgggga gttgcgtatg tccgactatt ccgaatttaa tgcgtgcgat aagcatcggt 2215141 taaggaagga cacgaactct tccacaggct gaataaacca tgaactttta catgtgtatc 2215201 acgtacaggt tgacgtcgtt gtctcattgt cattttggtt cagcctcctt tgcttttttc 2215261 ttactttgta agtatatcca ccaaattcca ttttgtaaac atctttttct aaaaatggac 2215321 ggaaattgtg caaatcatcg aatggatttg cccgttggtc atgacacctg cttcatttct 2215381 tttctggagc ggtctttctt atgatatgca ataaaataaa tgagaccgac aaatacagct 2215441 ccgccgatga cattaccgat aaaagccgga atgatgtttc cgatgaactg cccccacgtg 2215501 aatgagcctg caaaaatggc agcaggaatc acaaacatgt tggcgacaac gtgctgaaat 2215561 ccgatagcca caaaagccat gattgggaac cagatgccaa ggatttttcc tgctgcgtct 2215621 tgggcgccga aagaaagcca cactgcaaga catacaagcc agttacagcc gatggcggaa 2215681 atgagaacct tgccaaagct catatcaagc tttccttggg caacggcaat cgttttttct 2215741 aaataaggac ctgtttcagt caatccaacc aaatgcccga aaaagtaagc aacaaacaat 2215801 gcgccgatta agttcataat tgtgacgatt ccccagttaa tcgctaactc ttttactgat 2215861 atttttctcg aaaataacgc catcgcaact gacatcatat tgcctgtgat cagttcagcg 2215921 ccagcgagaa cgacaaggat caggccgact ggaaatactg ctgcaccaat caaactggac 2215981 aggctccccc attctttcgg aagatcgcca attaccctga tatcaagcaa atacccaagc 2216041 gcgataaatg caccgcctaa aaaccccagc acaagcagtg acggcagcgg gagctttatt 2216101 tttttcatcc ctgcttcaat tgctgcttcc gctatttcat ccggttttcg aaaagccata 2216161 ataaaacgcc tccattactt cttcttttct cacagttatg caagaaaggc aataaaaaag 2216221 gcagcactca aataacctgt gtcaaaccag gcgtttgaat gctgcctaac ttgtatgcat 2216281 acccatacaa caatatcaag cagtatataa gatattgaaa gagaatatat acagttcgtg 2216341 catacattcc attgctttag ccttctataa ctgtagcaac atcatatcaa atgtgacaaa 2216401 tttgtgtcaa tgacaaatat actagctttg cagagcttct ttttgctcat ctatttttcg 2216461 gtcaaaaaca aatacagata cagcgatgtt ttcctcaatt ttaatatcag aaaacaaatg 2216521 gactagctta gctcccataa gttcctccat tccttccggt gtttgtttgg aataaaggtc 2216581 ttgaattagg cttgtccggg ccgcatgtac catctctctt ccttcaggcg tgcgggcaat 2216641 aaactgctcg cttgcactca gatttccgta tagtgttgaa actgccatgt tttctacaaa 2216701 tacagtatga attctctcag gcccttttcc gaacaattct ttgcgaagtt ttcgaataat 2216761 atcattgaat tcatgaattt ttttagacat gctgattacc ccttccgata ttgccttata 2216821 aaggcttttc ccggttcccc tcaggacatt tcacttggtt aaaattttcc tgccatattg 2216881 tattataata aatatcacat tataataaaa gcagtgttga tggatttgta ataggatctt 2216941 gttatgagtc tatcgtttta taaaaatcaa ggattggtct gttagtaaga cttgctagtg 2217001 aactattccg ccatgtgtgt ttacaccttc ttagaattaa gggcaggtgt atctatacat 2217061 ggcttttttt gacttcttga aagaaagatg gaggggaata tgaatatgat ggacgttaag 2217121 tcgatcagtg tccgtgtaga cggaacagaa attcaagcac gagcaggggc cacaatttta 2217181 gatattttaa atgaaaacgg aattgagtac ccgcagattt gccacgtacc agaggttgac 2217241 ccgattcaaa cttgtgatac ttgcatagta gaggcaaacg gcaagctggt tcgttcatgc 2217301 gcgacggttg cagaaaacgg gatgtctatt gatctttcag gaaatcgagt gaaagaagcg 2217361 caaaccgaag cgatggaccg ccttcttgaa aatcatttgc tgtattgtac agtttgcgat 2217421 aacaacaatg gaaactgtac gctgcataat acagcggaaa tgatggggat cgagcatcaa 2217481 aaatacccat acacgccaaa agaagatcct tcttgcgcgg ttgatatgtc tcatcctttt 2217541 taccgctatg atccaaacca atgtattgcc tgcggccagt gtgttgaggt ctgtcaaaac 2217601 cttcaggtaa atgaaacact ctcaatcgac tgggaacgcg aacgccctcg cgtcatttgg 2217661 gatgagggag ttccgatcaa tgaatcttcc tgtgtcagct gcggtcagtg tgtaacagta 2217721 tgtccatgta atgcactgat ggaaaaatca atgctcgggc aggctggttt tatgacaggc 2217781 attaaagagg acgtcatgga accgatgatt gatctcgtga aaaatgttga accggggtat 2217841 ggcagcattt ttgccatttc tgaagtcgaa gcggcaatgc gtgaaacgag aacgaaaaaa 2217901 acgaaaactg tatgtacgtt ctgcggtgtc ggatgttcat ttgaagtatg gacaaaagga 2217961 cgggatattt taaagatcca gcctgtttct gatgctccgg ttaacgcaat ttccacatgt 2218021 gtcaaaggga aattcggctg ggattttgtc aattcaaaag agcggatcac aaagccttta 2218081 atccgtaaaa acggagcctt tgtggaatct tcttgggaag aagccctcga tcttgtcgca 2218141 agcagattag gatcaattaa agagcagtac ggtaaaggct ctgtagggtt tatttcttct 2218201 tctaaaatta cgaatgaaga aaactacgtc attcaaaaac tagcgcgtca ggtatttgaa 2218261 acaaacaacg tcgataactg ctcacgctac tgccagtctc ctgctacaga cggattgttc 2218321 cgcactgtcg gcatgggcgg tgacgccggc acgattaaag atattgccaa agcaggcctg 2218381 gtcatcattg tcggtgccaa tccggcggaa ggacacccag tgctcgcaac acgcgtcaaa 2218441 cgggcacaca agctccacgg tcaaaaactg attgttgctg acctgcgtaa aaatgagatg 2218501 gctgagcgat ctgatctgtt catcagccct aaacaaggca cagaccaagt ttggctgatg 2218561 gctgttacga aatatatgat cgaccaaggc tggcacgatc aggcgtttat tgatgagaac 2218621 gtcaattact ttgaagatta taaagaaacc cttaaaacgt atacgcttga ttatgcagaa 2218681 cgcatcacag gcctttcaaa agaaaacatc attcaaattg ctgaaatgat tcgtgatgct 2218741 gacggcactt gtgtcctttg gggaatgggt gtcacacaaa atacaggcgg ttctgataca 2218801 tcagcagcca tttcaaacct gcttctcgct acgggcaact atcgccgtcc aggtgccggc 2218861 gcttatcctc tgcgcggaca caataacgtg caaggcgcat gtgatatggg aacattgcct 2218921 ggctggctgc cgggatatca gcatattaca gatgacaaag cacgcgctaa atttgaagag 2218981 gcatatggtg tcgagattga tggaaagcct ggtttagata atattcaaat gcttcatgcc 2219041 attgaagaag gaaaaatgaa agctatgtat cttgtcggtg aggatatggc actggtcgat 2219101 tcaaacgcga accatgtgca tgatatttta tcaagccttg atttcttcgt ggtacaggac 2219161 atcttcctgt caagaacagc tcaatatgct gatgtcgtct tgccggccac tccttcactt 2219221 gaaaaagacg gaacatttac caacacagaa cgccgtgtcc agcgattgta tcaggcgctt 2219281 ccgacgcttg gtgacgcaaa accggactgg tggattattc aagaggtggc aaaccgttta 2219341 ggagcgaatt ggaattacag ccatccaagt gacattttct ctgaaatggc gagtctttct 2219401 cctctgtttg ccaaagcaag ctatgaggtg cttgaaggct ggaacagctt cctatggggc 2219461 agcttcacag gtgaaagcac accgcttctg tatgaagacg gatttaattt ccctgacaaa 2219521 aaagcccgct ttgccctttc tgattggacc gagccagcgg catttccgga ggaatatgac 2219581 cttcatatca ataacggccg gatgctggag catttccacg aaggaaacat gacaaataaa 2219641 tcgaaaggca tccaagcgaa agtgccgaat gtattcgttg agatctcacc tgagcttgca 2219701 caagagcgag gtgtttgtga cggttcgctt gtacggctcg tttctccgtt cggagcagtc 2219761 aaattgaacg cgctgatcac agaccgggta cggaaaaatg aactctattt gccaatgaac 2219821 tcgacagaca aggagtcagc gattaacttc ttgacgggcc ctgcagctga taaacggacg 2219881 aacacgcctg cttataaaca gacaaaggtc cgcatggaag tgcttggcgg ctgtgaaaca 2219941 gcgccgcttc caaaaacaaa tccgcgcaac aaaaaacggc atccgcaaaa cggagtcgaa 2220001 gcagaaagaa aatggaaccg ccctggctat gtacatctga ctgattaaac gataggagga 2220061 aaacgaatgg ccactccgat tacgacgatc aaaaaagaaa caaaaacagc tgagcaaatt 2220121 aagcttgaaa aaatagaaga actgaaagag ctgctggcgg aaaatgagga cgccgtctct 2220181 aaaacgatga cgttaatgaa tgaactcaat gatcttggaa tttttgatgc ggcaacaagc 2220241 atgctcagag cgaaggaaga cattgccaag attgcgcttg gccaagtttc ccgcgagcct 2220301 gtcaccaacc tcatcaacac gatgatggcc gccggaggcg cattgacaaa agccgatcct 2220361 gagtttacag caaagctttt agaaagcgta atggctggga ctgaacaggc acaaagcttt 2220421 ttaaaagaag acaagaaagt cgggattctc gacctgttaa aagcaatgaa cgatcctgac 2220481 atcaacagag ccgtcgggtt cggccttcag tttttaaaag gcatgggaaa agaacttcga 2220541 gaacaataac agaaaaacag ccatctctga tgatggctgt ttttttattc gtcggcttct 2220601 tccagacgct tcttgtaaat aagtgaacgg tcagcgcaaa agaaggcacc ggctaaaaat 2220661 acgcaatccg ctaaaaacat cgtcgatttc tggcctaatg ttaagccttg atcagggaga 2220721 actgcgccta tatataaaaa agtgctgact gcaagcaatg taaaagcaaa atgcttgtag 2220781 tcttctttta aagatttcat tctatttttg ttcaaaagaa tcacctgcca gattcatagt 2220841 atacgactat tataatataa tccggcggct tacagagaaa gtaattctat ccatttgtta 2220901 tatattttca agcgcttggc cgatatcttc caacaagtct tccgcatctt caattcctac 2220961 agaaattctg atcaagccgt ccgtaatgcc gagctcaagc cggcgttctc tcggaataga 2221021 ggcatgtgtc attcttgcag gaacagaaat taagctttca accgccccca ggctttcagc 2221081 aatggtaaac agtttcagat ttcctaaaaa cgcatcaacc cgttcttcac tgccaatatc 2221141 aaaggagatc atgccgccga agcccgctcc ttgcgttttt gcaagctcat gtccgggatg 2221201 atttgaagaa ccagggtaat ataacgtttg gacagcaggg tgattctcaa gaaagcttgc 2221261 gattttccgc gcattttgat cgatcgcttc cattctgagt cccaacgttt tgattcctct 2221321 cattaacagc caggaatctt gagggccgag cacgccgcct gtggagtttt gcacaaaatg 2221381 cagctcttct ccaagctctt tcgaagctgt cacaactaaa cctccgacga catcactgtg 2221441 tccgccaaga tattttgtcg cactgtgcag tacgatatca gcgcctaaag taagcggctg 2221501 ttgaaaataa ggagtattaa aggtattgtc tacgataagc agaacacccg ctttttttgc 2221561 gatatcagcc atgagcgtca ggtcggtgat tttgagcaac gggtttgtcg gtgtttcaat 2221621 ataaattgct tttgtattag ggcgaatcgc tttttcaact tcttccctgc tgctcgtatc 2221681 aacaaatgtt gattcaatgc caagacggtt aagcaccttt gtcatcacgc gatatgttcc 2221741 gccgtacaca tcatcagtca acacgacatg atctccgctg ttaaacagca tcataaccgc 2221801 tgtaatggca gccattcctg agctgaacgc atagcctgct tccccgcttt ccagttctgt 2221861 cacaagtgct tcgagagcgg ttcgagtcgg attggccgtt cttgaatact cgtagcctgt 2221921 atgctgccct gctttcggct gcttgtacgt gcttacttga taaatcggca cggaaactgc 2221981 gcctgttttc tcatcacctg tgattccgcc atgtatcatc aatgtttttt tcttcatatc 2222041 agatgcctcc ttcgtatatt tgtttgctga tatatcgatc gctgctgtca ggaaatactg 2222101 tgacaatgtt agttccagcg gatgcttttt tcgcttcctc caatgccgca taaagcgctg 2222161 cacctgaaga gcttccgatc agcaggcctt ctttttctgc cgcttctttc acaagtctaa 2222221 acgcattctc atctgttacg gtgtagatct cgtcaaaatg gctcttatcc atataatcgg 2222281 ggataaactc catgccgatg ccctctgttt tatgagcgtg gggctctcct ccgtttaaaa 2222341 tcgagcccac cggttcaaca atcaccgttt tgactgctgg atttttttct tttaagaagg 2222401 aagctgtccc tgcgaatgtg cctcctgatc ctgcccctgc gacaaatgta tgaatattcc 2222461 cgtcaagcgc ttcccacatt tcaggtccaa gcgtcttata gtaagtcgat ggatttactc 2222521 ggtttttaaa ttgcaaaacg caataagaat tttcaatttc agtctccagc tgaatggctt 2222581 tttgaatggc tccctgcatt ccgtcttgac gcggtgtatg aatgattgat gcgccaagcg 2222641 cttgcataat ttgctgtttc tctctgctga aatgttcagg gacacagaaa atcgctttca 2222701 gcccatattt tctggcactt aacgcaaggc cgatccctgt attgcctgcc gtagcttcta 2222761 taatcactcc gccgggtttc actttgcctg aatcgagcgc gtcacgaatc agcatatctc 2222821 ccagtctgtc tttgatgctt ccccctggat tcatcatttc aagcttggca tacaccgcga 2222881 ctccttctgg aacatcaaag ttcttcaagc ggagaagcgg tgtattccca atcagctcgg 2222941 taatgtccgt aatcactgtc atatatgtcc tcctccttaa tagaggttgt ttttagagaa 2223001 aaacggagga gaacgttctc cccgttttaa tgaattcgtt tgatcacctt taacacaagc 2223061 tctgttgaat gaacagccgc ctgctctaaa aattggtcaa atgaaacatg tgattctttg 2223121 cctgcgatat ctgataacgc tctgatgacg acaaacggcg ttttaaattg atggcatact 2223181 tgagccactg ccgcagcctc catttcaacc gcgtacagat cagaaaatct cgcacgcacc 2223241 tcttcaaccc gcttcggatc gttcatgaaa gaatcgcctg ttgcaatcgt tccttttgca 2223301 acctgaatgc cgtcgagttc agataccgct tcttcagtga tgctgatcag cttttcatcc 2223361 gccgcataag cagccggaag acccggcact tggccgtatt catagtcaaa agccgttacg 2223421 tctacatcat ggtggcgaac gtcagtggaa atgacgacat cccctacatt caatgtatga 2223481 tgaaatccgc cggctgagcc tgtgttaatg acataatcag gcttgtaacg gtcaagcaga 2223541 agcgtcgtgc tgatagcagc atttactttt ccaattcctg attttaaaag aatcacttca 2223601 gttccttcat attcgcctgt tgtaaattca cagtgtgcga tcgtttctgt ttttgcattt 2223661 tcaagtttgt ttcttaagat ggtaacttcc tcttccattg ctccgatgac tgctagtctc 2223721 atctattcac attcccttca ctttaccgtt tgatcgcctc cattatccac acgaagtcgt 2223781 tttgctgagt gaatcggact gcaaaacctt cagctgtaaa catttctttc aacgcatcca 2223841 atgtaggata atgctctgtc tctaaatcat ttgcaagctg ataaaagcct tgagaacggg 2223901 ctttatcgat agcctgttga tacgcttgcg cattttcaaa gacggtatcg gcaaacacta 2223961 ttttatcatg caagtgaagg tatttgccat attgctttat ggcagcccgc ttttcttcgt 2224021 cagtcaaatg atgaaaagca tatgaactga caatcgtatc agcctgaaat ggcggctcag 2224081 ggaatgtcag gaagtctcca tcaacgattt ccgtcctgcc tgagagcttg tcagaagcca 2224141 gtttacgcat tgctggagaa ggttcgattc caaatacagt tttgcctgca tcgagcagct 2224201 tagctgtcaa attcccggtc cccgggccaa attctaacac atgcgttcca gattttctga 2224261 cgatggcatc aaggatatga tcgtagcctc tgaacgcttc tttatactga atatctaaac 2224321 cttgtactgt ttgatcataa gttgctgccc aatcttcaaa gagagggata aattcacggc 2224381 ccatatttgt cacactccat atttaataat tcctataagt atactatgga ttaatgatgg 2224441 aacagttcct ataataccac atattctgaa aagcaggtac taaaacactt tgtgtatttt 2224501 atgccatctc atattgcgca ttgaccgcaa aaaagcttat acttcatatg acttgtgaaa 2224561 gctggagggt caagacatga attttcaatt agatctgatt aaagacaaag tggaattttt 2224621 tgaagcggct tcattgcagg agcttgaaaa gaaaatcaat acacaaattg aaaacaataa 2224681 agccatcatg ctccgggtga aatctgtttc acaccaaact cttgtggcag aaggaagaat 2224741 attgtacagc gcggtggttc atttctcagc tgaagcctaa aacaaaagca gccggtttta 2224801 acccggctgc ttttgtttat tttagctttt ctacttttgt cggcttccag cctttttcat 2224861 cgacccatgt aatcgtgact tgatatttat tcccagtcgc cttgtccaaa atcttgcctt 2224921 tggcatcctg agggctgccg ttatttccaa gccagagcac cgtcatgtta tctgttgaga 2224981 caccagttgc gtacgaaatg gctttcagca tctcagccca gtcttgtgag cttgaatcat 2225041 aagtagcggc atgctcgcca gtctgctcag ttccgactgc tttccagtca ggattttcat 2225101 acgttttttc cacatcgctc gatgagccgc cttctgttac ttttgcatct ttaagcccgt 2225161 caccggctga atctgagctt gaatctgaat cagagtcatc ttttttagaa gaagaatcat 2225221 cttttttgga atcagagtca gaagacttct cagaatcctt ttcgctgtca gatgtatctt 2225281 tcttgctgtc ttttatatcc tcatccgatt tcttttccgt ctttcctgaa gccggagatt 2225341 cctgtttttg cgccgtttca gaatccttgc tgacatcttt gctagaagga ctgttaatga 2225401 agagattcgc tgctactacg acaattagta tggatacgat tgcgattaaa atgttaagca 2225461 ctaaattggc ttttctgcgt ttatcacgat tttcataacg agattgatta ttgctcaata 2225521 attctgcact cctttatccc tcttggctca gcatatattt taacatgtgc tgagaagttg 2225581 ttctatttct gattgatttc aatttcgtgt acttttttaa caatatcata aaacaccgaa 2225641 tttgtcagag ccttatctcc cggtgtatcc atgtgtaaaa caactagagc gtatttcggc 2225701 ttatccgcgg gaaaatatcc ggcaaaccat ttttcgtaga gcgtttcctt ctcttttgaa 2225761 agcttgcctg tctgggctgt gcccgacttc cctgctacag tatacggaag atcttgaaac 2225821 cttctgcccg ttccggaagg agattctact acccgccgca gtattttttg aagctgctgt 2225881 gacgtatatt tgtctatcgt ttcccctttg agcttctgat ctttaaacgt aacgagcgtt 2225941 gtgccgttct tatactcaat ttgttcggca attttcacct gccgtttttc tccgccgcgg 2226001 gcgattgtcg ccatcatatt ggctacctcc agcggcgtta cctttacatt tttctgcccg 2226061 attgctgttt gcgcaatggc ttttttgact gatttgtctt tttcatcccc ccaaatcacg 2226121 ccgctttttt cgttatacag ctggcggaaa tcggtttcgt ggtacagttt tccctcccag 2226181 cctgcccgat cagtgagagc cagcttctcg gacatatctt caataaccga gctgtctttt 2226241 ttcattaatt gttctgcaag actcgtaaat gtgtaattac agctttgggc aaaactttca 2226301 tcaaaagaca aggtgccttt gtcgtccccc ggttccccgt acaggtttaa attgcaatta 2226361 aaggtttgac taggcttcac catattattt tcgattgcag ctgcggcaat gactgtttta 2226421 aaaactgatc cgggatagat tggcgtcagc atataatttt gaagtgtgtt ttgccgggac 2226481 acgtctgcat ctggtttgct tacaattccc agaacactgc tattttcgat gtccagcagc 2226541 acagctcctc cctttttcag cccctgttca tccaatacct cctccatcgc tttttgaatg 2226601 ctttgatcga tcgttgtttt gatctggagc ggataaaatg tattggcttc agctgtatat 2226661 ttgacgtcca tgccaaacaa agggtttcct tttccgtcca catgatataa aagctttgtg 2226721 tcttgttccg gaagcaaaaa ctcgtcaaat gtccgttcta aaccggttgt tccgatttct 2226781 gttgtaatcg gaaggctctc cttgtcagga tatttcttgc gaagcagcgc cggatcttgg 2226841 ttcgtgctcc ctatcgtatg tgaagcaagg ctgggcttgt cttcattctc catatatacg 2226901 ccgtaaatgc cgggatattt caaagaattg atttttgtga tagattgttt tgaaagtgtt 2226961 ttgattttct tttgctgcaa aatgaccggt ttttttgcct gacctagtgt ctggcgcaaa 2227021 tcatcttcag acatgccgag gatgtccgca acttttttga tcggccaatc ctgcgtcagc 2227081 agaaaaggga acaaaacaac cgcaggctcg ctttgtcctg tcagcgcccg cccgtttcga 2227141 tctaaaaaag agcctcttcc atctgaaatg agcacttcct ccgtccgctg tttcacactt 2227201 tcttgaatca aattaatttt ctttttagaa aatgattctg tgaaaaacag ctggatttct 2227261 gcaagtctca gcagaagcag aaaaaataca atcaaaaaag cgatgactgc cagcttcatt 2227321 cgtttcgata tcttcataaa aaaacacctc acccacattg tggacgaggt gtttcgctgc 2227381 taaacagata ttatgaaatt ttcacaattt tcacgagcat ttctccgccc ggtgtttgta 2227441 ctgtgacttc ttcatctact tttttgccca agaggctttt tgcgatcggt gaatcgtttg 2227501 agattttccc ttcaaacggg tcagcttccg cgcttccgac gatcgtatat gattcttcat 2227561 caccgtcagg cagttcgacg aaagtgacgg ttttacccaa accgacaacg ttagagccgc 2227621 cgtcatcttc aatgattttc gcattgcgaa tcatattttc aagagtcgtc acgcggccct 2227681 ctacaaatgc ctgctcttct ttcgctgaat cgtattcaga gttctcggaa aggtctccga 2227741 agcttctcgc aattttgatt cgctctacta cttcttttcg tttaaccgtt ttcaaatatt 2227801 ctaattcttg ttcaagtttt tgttttcctt ctgcagtcat aggaaaaact ttctcttgtg 2227861 ccatgtccct tcactccttc tggttgtccc tcaacatctt cgattatgta tgagagcata 2227921 aactaaaaaa tacaagaatg agaacacagg gcagtcctcg ttcttctctc ccatataggt 2227981 actgtttatc ttaaactgaa tcgtgtcgtt ctgcaaatat ttcgcgttta taaacaggga 2228041 aagaagggaa ttcgcacatt cccttcctgc ctatacataa tatggtcaga gttatttatg 2228101 tctatgctat ggtattacaa aatcgcgttt tgttcaagaa tggtttgaat ttttgtgacc 2228161 atcagatcaa ttgcgacgtg attctgaccg ccttccggga taataatatc agcgtatcgt 2228221 ttcgtcggct cgacgaattg gttatgcatc ggacggacca ctgacacata ttgttcaatg 2228281 acagaatcaa tagagcgtcc gcgctcatta atatctctca taatccgtct gatgatacgc 2228341 aagtcagcgt ccgtatcaac ataaagcttg atatccatca gatcacgaag ccttttgtct 2228401 tcaagaacaa gaatgccttc aaggataata acatcctttg gctctacgtg aaccgtttct 2228461 tctgaacgtg tgtgaagctt atagtcataa atcggctttt caatcgggcg gtaattcaat 2228521 agatcttgaa tatgctcgat taaatagtca ttatcaaacg caagcggatg atcatagttt 2228581 gtgttcagcc tttcttcaaa cggaagatgg ctttggtctt tataataaag gtcctgctgg 2228641 atcattaaaa ttgagtgtcc tttaaactgt tcataaatgg accgtgtgac actcgttttt 2228701 cctgaaccgg aacctcctgc gattccaatg actactggat tcttacccat gggctgttac 2228761 ttcccctttc tcatcatgtt gctcggataa atctttttgt ctagtttgaa tttgacaatt 2228821 tgcaggggat ggcgggcagc atctagctca tttccgtctt cgtcccaaat ggtttcaatc 2228881 gtatgtgtaa agttttcgat ttctggaccg aaaaattcca cttcgtcgcc ttttttgaag 2228941 aaattgcgct gctgaagcgt gaccatttgt gtatcttcat cataattcag cactaagccg 2229001 acaaaatcat atgtcgtttt cttggcgtgt tcgccgaaca tttgctcttc atagcctggc 2229061 gttccttcaa agaaagctgt cgcagtgtcc ctgttggcgc acttatcaag ctcttcaagc 2229121 cattcttttt gaatcacaaa gttttctgga tcagcgcaat aagcatcgat tactttgcgg 2229181 tatacgctga caacagttgc tacatagtga atggatttca tgcggccttc aatctttaag 2229241 ctgtcgatcc ccatttcaat catttttgga atggattcaa tcagcttcaa atctttcggg 2229301 ctcatcgcaa atggtgcatc ttcttcacca tacaaagcaa cggcgttggc accgtctgtt 2229361 tggtagagat cataatccca gcggcatgac tggcagcagc ctccgcggtt ggaatcccgc 2229421 gctgtcatgt gattgctcag cacgcagcgg ccggaatatg caatacacat tgcgccatga 2229481 atgaaggatt cgatttcgat atctaccttt tctttcattt ctctgatttc aagagcgcta 2229541 gtttcacgtg ccagcacgac gcggtcgaga ccttcttcct tccagaactg gacagccttc 2229601 cagtttgaaa gagactgctg tgtgctcaag tgaacctcaa cattcggcgc cactctgcgg 2229661 catgtttcaa taataagcgg atctgccaca ataataccgg caacgttggc gtctccaagc 2229721 gcttttaaat agtcttcaag cccgtccatg ttttcattat gagcgaaaat attcgttgtt 2229781 acgtagatct tcgcgccata tttctttgcg aattcaacgc cttctgcaat ttcttcgatc 2229841 gtaaagttat cggcattcga gcgaagcccg tattcctgtc ccccgataaa gaccgcgtcc 2229901 gctccgtaat gaacagcgat tttcagcttt tcaagattac ccgcaggtgc gagaagctcc 2229961 ggctttttcg taatcacacg ctttccatta acgattgtgg atattttatc atttacggca 2230021 gtcatagctt aacctccttt tgattaataa accgtttcct tgaagaagaa tccggtatca 2230081 atttttctgt ttactggctg gatgctttca atgcgttcga tccagtcttc ttttttcgct 2230141 tcgtattcgt cacggttttc cacgcacaaa tcaattgctt ctctgtacat tttggtgact 2230201 tctattaggt attcaggcat tttcaaaaca ccatcgattt tgaaagaatc aattccggca 2230261 tctatcaatt cctcgagctc atcaatgatg cacacatcgt tcgggctcat gatgtgagtg 2230321 ccgttttcat cttcgaaaat cggatattta ttatcgcgtt ctttatcgtg taaaaacatg 2230381 cctgattctt ttttctttct ttcaatgtcc atgactttgc cctgatattc aaaatagttt 2230441 ccaatcaaag aacgcttcga ttggaacatg cacgtcattc catgcacctg gatttcaatt 2230501 tcgacttcag cattttcttt aatctcaaca atgctgtcca tgtttaattc tctggcaagc 2230561 acagaacgcg ccgcaccctt gcgtccccag tagttgcatg tataatagtt ggtgcctgtc 2230621 gtttctgtgc tccaatgaag cttcagatca ggcgcagatt cacgggcagc catcagcacg 2230681 gcaggatcgc cgaataccgc tgcatcgaca ccggcttctg ctaagaaagc cagatattcg 2230741 ccaagctcac ccactttatc attatggaaa attgcattta cagcaacgta tacttttgcc 2230801 ccttctttgt gagcaatctc tacggctttt gttacatctt cacgagaaaa ttctccggct 2230861 aatctcaagc cgtatctctg ttccccaact aaaaacgcag ttgccccagc ctgtatgagc 2230921 ggcaaaatgt ccgctgtact cgtcggcgtc actaagagct ctggtttttt catgacgttc 2230981 acctcttctt tttactaatc gcaagtccgt ccccgacagg aataatcgca gtttgataat 2231041 ccggatgatt catcagccaa tgattatatt catcaatttt ggctacaagc ctgcgccttc 2231101 tcttcggttc tattttgctg taatcctctg ccaccagacc tttaaacagc acgttgtctg 2231161 ttataatcac cccgtccggt gaaagcatcg gttcatataa atgaaaaaag ttttgatact 2231221 gaccttttgc agcgtcaata aaaatgacat cgtaaggcgc ggttacatga acggcgtcgg 2231281 ctaattcaag cgcatctccg taaaaaacat gaatccggtc atcaagctga aattccttga 2231341 tattgtttac cgcttcttca tgccgtttct cattgcgttc aattgtatat atttcagcag 2231401 acggcagttc cagagccatt cgaatggctg aataaccaat ggccgttccg atttctagta 2231461 tttttttcgg ctgtttcaca gacaaaattt gaagcagcac ctccatgccc gctttttcca 2231521 taatcgggac atgatgttct tctgcatatg cttcaagtct cttcacgtta tccggccgag 2231581 gctttaataa tgcttctata tagtcattta tttgttcata ccggtcagtc actacaaaca 2231641 gcctcccgtt ctaaaaagga gtgccccagt cttatgcgca ggacactctc tgaatacatc 2231701 atgatacatc ggtaaacaac ccgatatatt ttatcataaa accttgcgga aagcgaacaa 2231761 aaggagagct ttttgctctc cttttatttc tcattttttg aggaaatgta tttttctttt 2231821 gctttattat gctcttttag cgtttttgta aatacgacct caccatttga tttggccaag 2231881 aaatacagat agtccgtttt atccggatgc agcgctgctt cccatgatga catgccggca 2231941 ttggcaatcg gccctggcgt cagccctgtg tttttatacg tattgtatgg tgaatcgatt 2232001 tccagatcct tataaagaac ccgatcttta tgcttgcctg ccgcgtacag gacggtcgga 2232061 tctgtttgga gcggcatttt ctttttcagg cggttataaa agacgctcgc aattttatgg 2232121 cggtcggctt tttcagtcgc ttcttcttct atcaaagaag ccattgtcag cagcttatgc 2232181 acagaaactt tgtttttctt catttctgat ttatatgttt ccacataaga atttgtctgc 2232241 ttaatcattg ccttgataat gtcttcaagt gatgtgtccg gatcgttaaa agggtatgta 2232301 gccgggaata ggtacccttc aagcgggtgc ttaatgtttt tattgaaaac atcatttgtc 2232361 acagtgtccg ggaattcttt cttcagctga ttgataaatg tttcatcgtc cagcttcgct 2232421 atgacttgtt ttttagagta ttttgtttca tcagcaatag cagccgcgat ttgggtcagc 2232481 tgtgctccct cagtcactgt gatttgaaaa gcgtaacctg tagccccgct tgtcagcttc 2232541 tgaataatgg catctaaatc cataccttta ttcagatggt agaatccggc ctgaaacccg 2232601 gaagcacctt tatatttcac atagtactga aacgccttct cgctttttat gacatcattt 2232661 ttctttaata tcgatgcgat ggctgaaaca gacgaaccgc tcggaatgtt aatattaact 2232721 gtcgttttac tgtctttttc aacaggttca agcaatgatt tcccatataa aaatgccccg 2232781 ccaatgatga gaaacagcac aacaatggaa gacagtatga ttcttttttt attaaaaaac 2232841 gatttttttt gctgattgat atacattagg tctcctccca tcagctctta tactacatga 2232901 ttcattgtat ttcggcaatt tattacaaaa agaggcctgc ataaagcaga aaaaagccgg 2232961 agcagtatag ctccggcttt ggtttggcgc gatgttttac tcttcgtctt cgtccgctaa 2233021 gaatgtgttt agtgtttctt cgatcatatc ccattcttcg tcagtttcaa tcgggaatag 2233081 ctcaccgttt tcaccgtctt cgtttggcgt gaagctggaa gcaagaattt ctacttcttc 2233141 gtcatctttt gattcgattg gatagtacaa gacataagat ttgccaaact cttcattttc 2233201 aaatgtaaac agcacttcac aaagctgttc atttccttga tcgtcaacaa ttgtaatatt 2233261 tttttcgccg tgttccattt tcttcacctc tggctttaat ttaagctgtc aagatatcct 2233321 tgtaaaatca taacagccgc cattttatca atgacttttt ttcgtttttg cctgctgacg 2233381 tcagctgcaa tcagcatttt ttcagccgcc attgtggtaa gacgctcgtc ccacagcaca 2233441 acaggaacat tgtacgttgt ttcaagcact ttcgcaaatg tttggctggc ttcgcctctc 2233501 gggccgactg ttccgttcat gttcttagga aagccgagca cgattttatc tatagtatag 2233561 tcctttatca gttcagataa acgggataaa ccataatcgc cttctgcttc atttatcttt 2233621 atggtctcaa tgccttgagc agtccagccc atttcatcgc tcagagctac accgagtgtt 2233681 ttggttccta aatcgagtcc taatattctc attctttatt tacgcctctt tatgctgttc 2233741 taaataagac tttaccaatt cctcgattaa ttcgtctctt tcaagtttgc gaattaaatt 2233801 gcgagcgtca cgatgcctag gaatataagc gggatcacct gacagcaagt atccgacaat 2233861 ctggttgatt ggattgtagc ccttttcctg aagcgcgtca tacactgtaa tcagcacctc 2233921 atttacgtta gtctcagcag aatcatcgga gaaattaaat ttcatcgttt tatcaaacga 2233981 gctcaccgtt ttgcacctct ttcccaaatt cgcaggcaaa gttcagcctg gggtcctaat 2234041 cttaccatca ttctacacta catgggcgaa ttataaaacg gatttcaccc aatcttctac 2234101 agaagccaaa gcttcttcta atttttccgg ctgtttaccg cctgcctgcg ccatgtccgg 2234161 acggcctccg ccgcctccgc cgcaaacttc cgcagcttgt ttaaccagct tgccggcgtg 2234221 aagtcctttc tcaatgaggt cctttgtgac tccggcagag atattaactt tatcgttttg 2234281 taccgcacca agcacgatca ccgcagagcc aagctttgct ttgagttcat cgaccatagt 2234341 gcggagatga ttcatgtctt ttgcatttac ttttgccgca agcacgttta cgccgtcaac 2234401 ttcttttact ttcgacagga ttgctcctgc ttccacgttg cctagttttg caagaagaga 2234461 ttcattttct ctttgtgcat ccttcagttc agcctgcaga gccgcgaccc gtttcggcac 2234521 ttctttgata tttgttttca gctcgtcagc ggtctgcttc aatacagaaa tctggctgtt 2234581 catttcgacg taagcgcctt gtcccgttac agcttcaatc cgtcttgtgc ctgctccgat 2234641 tccggattca gaaacgattt taaacaagcc gatttctgct gtatttctga cgtggcagcc 2234701 gccgcacagc tctaagctgt aatctccaac ttgaacgaca cggacaatat cgccatattt 2234761 ttcgccgaac agtgccatcg cacccatttc ttttgcttca gcgatcggtt tcaaatcaat 2234821 gctgaccggg atgctcgccc agatcttttc gtttacgatt ctttcaattt gttcgagctc 2234881 ttcttttgtc acttggccaa agtgcgagaa gtcaaaacga aggcggtttt ccgttacaag 2234941 agagcccgcc tgattgacat gagttccaag aacatctttt agagcctgat gcaataaatg 2235001 cgttgccgtg tggtttttaa tgacgccgct tctcatatgg tcttcaactt cagccgtaac 2235061 atgcaggcct ttttgaacag taccgctctc cacaacacct tcatgcacat gctggccgtt 2235121 cggcgctttt tgaacatctt taattcttac aactgcctgc tcgcttcgga gatagccttt 2235181 gtcgccgatt tggccgccgc tttctgcata gaacggtgtt tcatcaagaa tgatttgaac 2235241 gctttctcct tcatgagcct cttcgattaa ttggccgtcc tgaagaagca caatgatatt 2235301 ggcatcagct ttggtttgag agtagccgac aaatgtgctt tcaactgtca cgtcgcgcag 2235361 tgcgccgccc tgcacctgca tgctgccgac atcctggcgg gcgtttcttg cccgttcacg 2235421 ctgctggttc atttcctcct caaagccctc atggtcaacc gtcatgttct cgtcttctgc 2235481 gtattcttca gtcaattcaa ccgggaatcc atacgtatca tacagtttaa acacatcagc 2235541 acctgagata acgctgctgc ccttgtcttt ttcttttttg atcatttctg acaggatcgc 2235601 aagcccttca ttaagggtct catggaagcg ttcttcctcg gttttaatga cttttgcgat 2235661 gaaatccgct ttctctttca cttcaggata gaaatcagcc atgatttctg cgacaaccgg 2235721 cactaaatca aacatgaacg gacgatggat gttgatcgtt ttggcataac gcacggcacg 2235781 gcgtaataag cgtcttaata catagccgcg gccttcattt gacggcagcg caccgtcact 2235841 gacagcaaag gcaaccgttc tgatatggtc agcaatcact ttaaacgcag tgtctttcac 2235901 attgtctttg ccatatgttt caccagaaat cgattctgtt gctttaatga tcggaacaaa 2235961 caaatcggtg tcaaagtttg tcggaacatt ctggatgaca gacaccattc tttcaagacc 2236021 catgcctgta tcaatatttt tctttggaag cggtgtgtac gtgccgtcag ggttatggtt 2236081 gaactctgag aacacaaggt tccatacttc caggtaacgg tcgttttccc cgcctgggta 2236141 aagctccgga tcttctggat cattaccgta tgcttcaccg cggtcgtaaa agatttccgt 2236201 attcggtccg ctcggccctt caccgatatc ccagaagttc ccttccagac ggataattct 2236261 ttcttcagga ataccgattt ttttcgccca aaactcatat gcctcttcat cttcaggatg 2236321 aaccgtaaca gagagaagct ctttgtcgaa gccaatccac ttgtcgctcg ttaaaaactc 2236381 ccaagcccat gtaatggctt cttctttgaa ataatcgccg atggaaaagt ttccgagcat 2236441 ttcaaagaaa gtgtgatggc gcgcagtttt acctacattt tctatatcgt ttgttctgat 2236501 cgctttttga gcgtttacga ttcttggatt ttccggcacg acacggccgt caaaatattt 2236561 tttcagcgtc gcaacaccgc tgttgatcca aagcagtgaa ggatcctcat gaggcactaa 2236621 tgacgcgctt ggctctaccg catgtccttt ttctttaaag aaatccaaaa acatttgacg 2236681 cacttccgca gaagttaagt gtttcattgt atttcctcct ctataaaaat cgaaattctc 2236741 ttcagtgaca gcaaaaaagc cctcccccta tgcaaaccaa cgtttacaca gggacgagag 2236801 ctgtctcgcg gtaccaccct gattacgggc attcatgcgc ccgtcacctt taaccctgta 2236861 acgcaggata agcggcagtg attaactgca ctcaggatta gcttcctccg atcttctgat 2236921 aaagctcctt tcagcttatg gagcttctct ctttaacagg gcttcggcgt actcagatcc 2236981 gtcactcgag attcgtatgt attctacgag aaattataga caagcggcac gccgatgtca 2237041 atgctccgtc ctcatccgca aaaaatggat catcattact tttaaaacag ccgtcgcagg 2237101 aacagccaga atcatcccga cgatacccgc aagctcccct ccggcaagga gtgcaagcat 2237161 gataacgacc ggatgcattt taaggcttct gccgacaatg aacggactga ggatatttcc 2237221 ttccataaac tgcagaataa acaccgtaat caccacaaca agaaccgcct tgactgagat 2237281 cgtcatcgca attaacaacg caggaacagc tccgatgaaa gggccaaaat acgggatgac 2237341 attcgttacc ccagagataa ggccaagtat cagcggatac ggaagcccaa atacccagaa 2237401 cgaaatgcct gcaatcacgc caagaatcaa gcagaccaaa agctggccgc ggatataatc 2237461 gccaagcgaa tcatccacat cccgcaaaaa ggcgctgccc cgctttctcc acgacttcgg 2237521 agtcaagtac catactgtct ttttcattaa ctcaatgtcc ttcaccatat aaaacacgag 2237581 aaaagggatt gttgcagcaa ttaagaagta atcaagcaca ttgcggatcc cgctgatcgc 2237641 accctcgatc gttcccgcaa aaaacgcctc cgtctggcgg atcattttat ctatacggtg 2237701 atgcatacca tcaggccagt catccgtatg gttatgcaca tgaagaagaa gcccgttata 2237761 cgtttcggca aacatgggta tattttctga caaatccgtc agctgcacga ttaaaacagg 2237821 caccccttta tacaacgccc agccaatccc gccaaaaaaa agaacataaa tgaccaagat 2237881 gctcaaagtc ctaggcaatc ctttgccatg cagccattct gtgaccggaa gcaataaata 2237941 agatataaaa atagaaatga tcaagggaat aaagatcgtt tttatgacga gccaaaaggg 2238001 tgaccataac atatcaagca taaaaaagac atagactgtt aacagaacca gcaaacaaat 2238061 agccacccac aacaaaagct gcaccggttt ttggagcatc tgctttcacc tcacctatat 2238121 cttttgaggt ttacaaggaa ttattcttta tgtttcttta gtcagtcaga agtcatggac 2238181 attttttcac ttttaatttt cagaaaagtt tgatcattta ctttttggtc aaattttctg 2238241 ataggaggat tgcgatgatc acatttcaaa atgtaaacaa gcattacgga gattttcacg 2238301 tgttaaaaca aattaatctt caaatcgaaa aaggtgaagt cgttgttatc atcggcccat 2238361 ccggttccgg taaaagcaca ttgctcagat gcatcaacag acttgagtcg atcaatgagg 2238421 gagtgcttac agtaaacggc accgccatta acgacagaaa aactgatatc aatcaagtgc 2238481 ggcaaaatat cgggatggtg tttcagcact ttcatttata tccgcataaa acagtgctgc 2238541 agaacatcat gctggctccg gtaaaagtgc ttagacaatc acctgaacaa gcaaaggaaa 2238601 cggcgcggta ctatcttgaa aaagtcggca tcccagacaa ggctgacgcc tatccttccc 2238661 agctttccgg cgggcagcag cagcgtgttg ccatcgcaag aggactggcg atgaagccgg 2238721 aggtcatgct gtttgacgag ccgacatcag cacttgatcc tgaaatgatc ggtgaggtgc 2238781 tagatgtcat gaaaacactc gccaaagaag gcatgacaat ggttgtcgtg acacacgaaa 2238841 tggggtttgc caaagaagtt gccgaccgga ttgtcttcat tgacgaagga aaaattttag 2238901 aagaagcagt gccggctgaa ttttacgcga acccgaagga agaacgggcc cgcttattct 2238961 taagccgtat tttaaatcat taaaacagaa atgggggagc ttgtatgaaa aagatttttt 2239021 ctttagcatt gatttcttta ttcgctgtca tcttgcttgc cgcttgcggc agcaagggat 2239081 caaacggaga agcctcaaag gagagcaaaa aagatacgct agccgccatt aaagacaatg 2239141 acaaaattgt cttcggcgta aaaacggaca ctcgactgtt cggtcttaaa aatccaagct 2239201 caggtgagat tgagggtttt gatattgata ttgctaaaca aatcgctaaa gacattttag 2239261 gtgatgagaa aaaagctcaa tttaaagagg tcacctcaaa aacaaggatt cctatgctgc 2239321 aaaacgggga tatcgacgcc attgtcgcca caatgacgat cactgaagaa cgaaaaaagg 2239381 aagttgactt ttctgatgtc tatttcgagg ccgggcaatc gcttctcgtg aaaaaaggca 2239441 gcaaaatcaa gagtgtcgag aatcttggca aaggctcaaa agttcttgca gtaaaaggct 2239501 ccacctcctc tcaaaacatt cgtgaaaagg cgcctgaagc atctgtttta gaatttgaaa 2239561 actacgcaga agcctttaca gcccttaaat cggggcaagg cgatgccctc accacagata 2239621 atgcaatttt atatggaatg gctgatgaaa ataaaaatta tcaattaaca ggaaagcctt 2239681 ttacagatga gccttacggg atcgccgtga aaaaagggca atctgctctc gcgaaagaaa 2239741 tcaacgcttc acttaaaaag atgaagtcgg atggcagata cgatgaaatt tataaaaaat 2239801 ggatcaaaga agacccagct gaataacaac catcccggga tgagcaggcg atgctcatcc 2239861 caatttgata aggagtgaat aggcagatga atgtgtcaat tcttttcgat aacttcagca 2239921 tgtatatgga cggtttttac cataccttgc tcgcaagtgt tatcgcgctg gccggcagtt 2239981 ttgtcctcgg cgttgctgta gcggttatga gaataacagt ctttaagccg ctgcaatggc 2240041 tcgggaccgc atatgtagaa ttcatccgca acatccctct tcttttaatt acctttgttt 2240101 tctatttcgg acttccaaac gcaggcctga ggcttgacgg ttttcaagcg ggaacggttg 2240161 ctctcaccat ttatacctct gcgtttatcg ctgaagccat cagagcaggc atccagtctg 2240221 tttcaaaagg gcagatggaa gcggcacgct cgtcaggctt tacctacagc caagccatgc 2240281 tccatatcat tttgccgcag gcaatcaaaa tcgtcattcc gcctttaggc aatcaatttt 2240341 taaacttagt caaaaactct tcgattcttg gggttgtggc cggattggat cttatgtacc 2240401 aagccgattt agtttcgtcg agcacactcg ttgtatttga tgtttatatt tttgtggcgc 2240461 ttttttactt agtgctgacg attccgctta gcatcggtgt taactatctg gaaaaacggc 2240521 tggaaaaaag ctattgataa ggagtgagtt acattggatt tcatcggtgc ttattcacag 2240581 gagcatttag cgtttttatg ggatggcttt ctcgtcacct tgtacgttgc tttcatctcc 2240641 atcattctga gctttttctt cggtttaatc gcaggcaccc tgcgttatgc gaaagttccc 2240701 gttctttctc aattgattgc agttctcgtt gaaacgatca gaaacctccc cttgctgtta 2240761 attattttct ttacgttttt tgcccttccg gaaattggga ttaagcttga aattacagct 2240821 gctgcaatta cagcactaac gatttttgaa tccgctatgc tatctgaaat tatccgaagc 2240881 ggactgaaat caattgacaa aggacaaatt gaagcggcgc gctcctccgg gctgagctat 2240941 acacagaccc tgttctttat cgttatgccg caagcgcttc gccgcatggt tccgcccatc 2241001 gtaagccagt ttatttcttt attaaaagat acatcgctcg ctgttgtgat cgccctgcct 2241061 gaactgattc acaacgcgca aattattaac ggccaaagcg ctgacggcag ttattttttc 2241121 ccgatctttt tacttgcggc ccttatgtat ttcgcagtca actacagcct ttcactcgca 2241181 gcaagacgcc tcgaggtccg gcaaacatag aaaaggatac tctttggaga gtatcctttt 2241241 tgcattaaaa cattttcgta attcttcttc tcatccgctt catgcttcga ttattcagca 2241301 tgtcagattg agtcgccatt cggtacacga gagctccggc tcccattgcc aaaagagaag 2241361 tcatcgtccg attcatcctg cgcatctcct ttcatgatta aaaattgatg ctgcgttcat 2241421 cctcagaaaa caaatcatcc aagctgctta acgttccgtc ttcttccacc tgatgagttg 2241481 caatcttccc tttcgccact gtcagttcaa taaaacagcc ccagcaataa tattggttca 2241541 cgccgatttt gccgatatcc ttacttttgc aattcgggca tataagcata cctcacacct 2241601 ctatccgttc agaacgatct cgtctttccg cacctcgaca agcgaatccg ctctttggat 2241661 ctggcgcttg cttcccgcca ggtcagaaaa gaaaccgtcc gagagttcat atgctacgat 2241721 tatgcccctg tccaaacaaa agtatacatc ttccagcatc cccaatatat ccccctcttg 2241781 cgatttcaca agcttcatct tcatctgctc gtatgtgaag catgatttcg gaagaggcaa 2241841 aagctgttct gaactgaccg aagccaatat gcggtcatca aaaatggaag agatatcaca 2241901 cgcccgtaat agcgcatgat gatgatgcaa aaagcgtttt tgtgcaagaa taaacccaag 2241961 acaatctcct ttcagagaaa aacaaatatc ggaaattgtc ccgagataac tagaagttcg 2242021 ttctgagtat actgggaatc cttctacttc atggcatgtt ctcaaagtgt gatcaaccac 2242081 cttttgttga acaggcttag gttttgcttt gcgccttaga ctcatacgat gaaatcaatt 2242141 ccactgcaaa tgaaaaaaaa ctcccgcttg cacgggagca ttttattgct gttcttcttt 2242201 cataaaatcg aatggtgtaa tgccttccat gccaatgttg gcgtcgtgta cgctgaacgg 2242261 gagctctttt tgcaaagctt caagctcggc atccatttcc tcaacctgta cggacagcct 2242321 gtttttcaag gaggtctgtc tgacagttgc atcattattt ttcacgcccc actccagcgc 2242381 ctcctcttcc ccgcataaaa tgagaaattt cttcgctctt gtaatcgcgg tataaagaag 2242441 gtttcttctg agcattctat aatagccttt cacaacaggc aaaaccacaa tcggaaattc 2242501 acttccctgc gatttatgaa tagaacagca atacgcatgg gtaaattgat taaaatcttt 2242561 tttcgtaaat gtcatttcat tgccgtcaaa agaaacgacg gccatgtctt ctttttctgt 2242621 attttccttt gcataaaata tcgacgtgat ttcgccaata tctccgttga acacattgtt 2242681 ttccggctga ttgacaagct gcaaaatttt atctccggtt ctgtagacaa catccccgaa 2242741 cttcaattct ctccgttttt ctttaggagg atttaaaatg tcctgcagca tcacattcaa 2242801 ttcattaatg ccggcttttc ctctgtacat cggagcgagg acctgaatgt cctttgctgt 2242861 atagcctttt ttcaatgcat tggcgacaac cttctcaact acttctttga tttgcgaccc 2242921 gccgcagcga ataaaggaac ggtcctttgt cggggcagtc aaattgttcg gcagcaatcc 2242981 atttttcatc tggtgggcaa gctcgacgat tgatgaccct tctgcctggc gatagatgtc 2243041 tgtcagtctc acagtcggaa tcacctggga tgccagcagg tctctgagca cttgtcccgg 2243101 accgacggaa ggcagctggt cttcgtctcc gacaatgatg atttgtatat gatcagggat 2243161 cgccttgaac aaatgattcg ccagccatat atcaagcata ctggcttcat cgataattaa 2243221 cagcttccct tcgatcggct gatcctctgt atgagtaaag ccttcagcgc cgttccagcc 2243281 aagcagcctg tgtatcgtaa ctgcagggag tcccgttgat tcactcatcc gttttgctgc 2243341 tctccctgtc ggagcggcca aaacaatcgg aaaagcttca tcctttttat aagctgacgg 2243401 gtctagtgac acaccgtgaa gctctccgta gagctcgaca atccctctga ttaccgtcgt 2243461 ttttcctgtt cccgggccgc ctgttaaaag aagcatcggc gaggaaaggg ctttttgaat 2243521 cgcttccttc tggctggggg catactgaac gtccatccgt tcttccagtt ctcccaacgc 2243581 gagcaaaaac tctgattcgg gaaactggtt ctcatattcg gtttggctag cgatatgttt 2243641 cacacgcttt gcaacgtttt gttctgcgta aaacagcgaa ggaaaataac agcggccatc 2243701 ttctatgaca atgtctttat tttctccaag ggcaataatt gcgttagcgg catccatttc 2243761 tgtaatgcgc tgcccttccc ttgctgactg gtttaacagt gattgagtgt cgatgatcag 2243821 ctgttccgtt tctatgtacg tgtgcccctc tgacagacaa gtcgtttcaa gcgtgtacaa 2243881 aatagcagct tttacccgct caggatgatt acccgaaaga cccattctgc tgcccagctc 2243941 atccgctttt ccaaacccga tgccttctac atccttcaca agctgataag gattttcctg 2244001 aatcttttca agcgtctcgg attcataggc ttgatagatt ttcatagaca gctgcgggcc 2244061 aaagccaaac tgattcaagg aaatcatgat ttgctccagt ccctgatgcc gctgcaatgc 2244121 gccagccagc gtgtctgctt tcttttttga gagtctggga acatcataaa gcactgaagc 2244181 atcagccaat attttattaa tggcgctgtc gcccagcttt ttcacaattt cttcagctgt 2244241 ttttttgccg atcccctcga ataaatcact cgataaatat tgaatgatgc cttccttagt 2244301 cgttggaatc tcctttttga aatgctccgc ctgaaattgg agcccgaatt ttggatgggt 2244361 tacgatcttt ccgtaaaacg tgtaggtctc ttcttcttga agcgcaggga agtagcccgt 2244421 cacggatacg gctttatctt caatggcttc ggaggtctct gtgactttca ctttcagaac 2244481 cgtatataaa ttggtgtcat tatgatagat gactgtgttg actgtccctt ttaaataggg 2244541 ctcttcctcc agtttaagct gatccggatg ctgctgcacg agctgtccct cctcctgtgc 2244601 ctgttatgat ggatcaatca gttttttagc atgaagcgca agcatatgat ctggctggat 2244661 atcgattgcc ttgtccagca tttccagcgc tttttctcgg ttttctttat aagcataagt 2244721 gacaccggca ttataaaatg catctgcatg ccccgggtct tgctctgtca cagctgcgaa 2244781 ttggctgagc gcttcgtcca gcatgccctc gttggctaag cacatcccga attgaaaacg 2244841 cgcttccgta tcgttttcat tcagttcgac tgctctttgt aaatatggca gtgcaagctt 2244901 aggctgttcg agcttgacaa gtaccgttcc gagcatgtaa aacaggtcgc cgttttccat 2244961 ccccgcacgt agcgcttttt caaacatgtc tttcgcttct ttgtacattt cttttacaac 2245021 atagacattt cctgctccat aataagcagt ggctgcgcta ctgtctaatt caagcgcttt 2245081 atcataaaac gcaagcgcac gttccagctc gtttacggat gaaagaaggt tggcaaaatt 2245141 gatatacgga atcgcgtctt ctttattttc ttcaatcgct tttgtaaatg cctctgccgc 2245201 tttctcgtaa tcgccttcct gcatcgcctc tataccgagt tgattataat ccaccgatca 2245261 tcttcctttc attaaaaaac cccaactcag tgttgaggtt tttcatcttt tatacgtacc 2245321 acaattttgt tccgtctttg tacacatcat caattgtccc gccgccaagg cattcttcgc 2245381 cgtcatagaa gacaacggct tgtcccggcg ttacagcgcg gacttgttca tcaaagatga 2245441 cttccgcttc accttcgcca gtcatgcgca ctgttacttt atgatcctct tggcggtaac 2245501 ggaatttagc cgtgcaggaa atctcttcgc ccttcatgat atccgaacgt acccagctga 2245561 tatttgttgc tgtgattttg tcggaatata aaagcgggtt atggaaccct tgatctacgt 2245621 agaggatgtt cttttcaaga tctttgccta ccgcaaacca cggctcgccg cttccgccga 2245681 tgccaaggcc gtgacgctgt ccgatcgtat agtacatcaa cccgtcgtgg cggcctttta 2245741 cttcgccgtc catcgtcatc atatcgcccg gctgtgcagg gagatattgg ctgagaaacg 2245801 ttttgaagtt gcgttcgccg ataaagcaga tgcctgtact gtcttttttc gtcgctgttg 2245861 caagttctgc ttctttggca atttcacgca cacggctttt ttgaagttcg ccgatcggga 2245921 acatgacttt gctcagcgta tcttctgtca gctgattcag gaagtacgtt tgatccttgt 2245981 tttcatcaat gccgcgcagc attctgactt ttccgccgct tctgtctact cttgcatagt 2246041 ggccagtcgc taaatagtcg gcgccaagtg acaatgcatg ctccaaaaag gccttgaatt 2246101 taatttcttt gttgcacaat acatccgggt ttggtgttct gcctgcttta tattcatcaa 2246161 ggaagtattg aaataccttc tcataatatt gcttttcaaa gtttacggca taatacggaa 2246221 ttccgatttg gttgcagacg cggatcacat cttcataatc ctctgtcgcc gtgcaaaaac 2246281 cgttttcgtc cgtatcatcc cagtttttca taaagattcc gattacatca tagccctgtt 2246341 cttttaacag cagggccgcc acagatgagt ctactccgcc ggacatgccg acgacgactc 2246401 ttgtatcctc cggccgtttt tccatttcat tcactccaat tactacgccg ccttattatg 2246461 tcagccgttt gacaacgtcg gccacatgtt tggcagcagt tttcacttgc tcagccgtat 2246521 tgccgaggcc gaagctgatt cgaatagagg acgtcagccg gtcactctct tcgccgaaca 2246581 tagcagtcag aacatgtgac ggcaggactg aaccggccgt gcacgctgaa ccgctggaga 2246641 cagcgacacc agccatatca agattaacca gcagcgcttc cactgacaca ccggggaaat 2246701 aaagattcag aacatgcggc agactatgct ctttgtcccc gttgacctcg aatgccacac 2246761 ctgcatctct aagcgtgtcg gcaaagattg ctttaaacga ttgatacttc tcgttttttt 2246821 cgtcacgttc ttcacttgac agcttgatcg cttctttcag cccgacaatg cctggaacat 2246881 tttccgttcc ggcacggcgt tttctttctt gctctcctcc gaataaaagg ggtgaaagct 2246941 tcacatcttt actagcatat aaaaagcctg tcccttttgg cccgttgagc ttgtgcccgg 2247001 aaacagacag aaggtcaata tggctgtttt tcacatcaat tggcagcaac ccgaatgcct 2247061 gaacagcatc ggtatgaaaa taagctttgt gttcctttaa cagctcaccg atttcttcga 2247121 tcggctgcac tgttccgact tcattatttc catacatcac tgtcacaagg attgtatcat 2247181 cacgcagtgc ttctttcacc tgttttgcac tgactcttcc attttggtca acgtccagat 2247241 acgttatgtc aaatccgtct ccctcaagtt tttcacatgt gtgaagcacg gcgtgatgct 2247301 caatttttgt tgtgatgata tgtctgccaa gatcttttct tgcaagtgcg gttcccatga 2247361 tcgccaagtt atcagcttcc gttcccccgc ttgtaaaaat gatctcctgc tctgccgctc 2247421 cgatttctgc tgcgatctgc gctcttgctt catccaccca ttttcgagat tctctgccaa 2247481 atgaatgaat actggaggga ttaccgaaac tgccggagaa gtgcggtatc atttgttcca 2247541 gcacgcgctc atccatcgga gacgttgcgg catgatctaa ataaatccgt tccattatgt 2247601 ttacacctct gatctaaata tagaacatat aagcttcttg ctctccgtct gtatagctgg 2247661 caagatcctc taatgttgta ctgtctaaaa cctcttttac agcatcccgg atgcgaatcc 2247721 agagctcacg cttggcaggc tcctcatctt ccagcacttc aacagggctg atcggcccct 2247781 caagcacacg gataatatct cccgcagtaa tggcatccgg ctcactgcct aatacatatc 2247841 cgccatatgc gcctctgatg cttttcacta aaccggcatt tctgagcggc gataccagct 2247901 gctccaaata atgctcggac aaattattcg tctgtgcgat gctttttaat gaagtcgggc 2247961 cttcaccgtg cttttttgca agctcgatca taatggtgag cccgtatctt cccttagttg 2248021 atattttcaa catgaacacc tctgttattt catgattttc cacatttata atggtaattt 2248081 ctatatgttt cgtccgttta ttatcttata gaccaactgt tattataaca taccttcagc 2248141 gaattttcat tgaggcagaa ggaaaggggc ctttaccctt ttctaatgta cggttttccg 2248201 ttaccctgta attaagtaag gagagatgat agatgaagcc attggcatat cggatgcgtc 2248261 cgacaaaaat agaggatatt atcggccagc agcatctggt ggctgaagat aaaattattg 2248321 gcagaatggt ccaggcaaaa catttgtcat ccatgatttt gtacgggccg cccggaattg 2248381 gaaaaacatc aatcgcaaca gcaatcgccg gttcaacaag tattgctttt cgaaagctga 2248441 atgctgtcat taacaataaa aaagatatgg aaatcgtagc tcaggaagcc aagatgtccg 2248501 gccaagtgat tttgattctg gatgaagtcc acaggctgga taaaggaaaa caggattttc 2248561 tattacccta tttagaaaac ggaatgatca ttttgatcgg agcaacgacg gctaacccgt 2248621 atcatgccat taatccggcg atcagaagcc ggacccagat ttttgagctt gaaccgttaa 2248681 cacctgaact gattaaacag gcactggaac gtgcgctcca tgatgagcat cggggccttg 2248741 gcacctattc tgtatccatt gatgatcagg cgatggagca ttttgcccac ggatgcggag 2248801 gagatgtccg ctccgcttta aatgcgcttg agcttgccgt gttgtcaacg aaggagtcag 2248861 cagacggtga aattcacatt acattagaaa ccgcggaaga atgcttgcag aaaaaaagct 2248921 tttctcacga taaagatggt gacgcgcatt atgatgtact gtccgctttt caaaaatcaa 2248981 tccgcggctc tgatgccaac gctgctcttc actatttggc tagattaatt gaagccggtg 2249041 atctggagag catcgcaaga cgattgcttg ttatcgccta tgaggatatc ggtttagcaa 2249101 gcccgcaagc cggccctaga gtgctgaacg ctattcagac cgctgagcga gtcgggtttc 2249161 ctgaagcgcg aatcccgctg gccaacgcag ttattgagct ttgcctctca ccgaaatcaa 2249221 actctgccat tctggcaatc gatgaggccc tggcagatat cagagccgga aaaattgggg 2249281 atgtcccgaa gcatttaaaa gacgcgcatt ataaaggagc tcaggaatta ggaagaggaa 2249341 tcgactataa atacccgcac aattacgaca acggttgggt cgaacaacaa tacctccctg 2249401 atcctctgaa aaataagcaa tactataagc cgaaacagac tggaaagttc gaatctgcct 2249461 taaagcaggt gtacgataaa ttaatgaaaa gaaaataaaa caaaaaaaca gccttgatca 2249521 tcaaggctgt ttttatgcat tatttatcct tcacacgttt gatttcaatg tctttcaaaa 2249581 gatccatgac aacatgtccg cccataatca aacctgcaac tgacggcaca aaagcattag 2249641 aggaaggcgg catttttgct ttacgtattt tcgcttcgtc attccccact tcttttctga 2249701 catcttcccg aataacaatc gggctttcat cagagaaaat cacttgaacg ccttttttga 2249761 taccctcctt gcgtaatttc gtacgaacga ccttcgcaat tggatcagtg tgcgtttttg 2249821 agatatcagc gatttggaag cgtgtcggat ccgttttatt tgcagcaccc atgctggaga 2249881 tgagcggaat atcccgtttt agacattctt tcattaaatg aattttataa caaatggtgt 2249941 ctgacgcatc aatgacatag tcaagaccat agtcaaaaaa ctgctcatac gtttcctccg 2250001 tatagaacat ttttaacgcg atcacttcac actccgggtt aatgtctgcg atccgcgcct 2250061 tcattaaatc aactttcggc tgtccgacag ttgaaagcag cgcgtgaagc tgacgattta 2250121 catttgtaat gtcgacatca tctttgtcga caagcagaat gcggccgacg cctgaccgcg 2250181 cgagagcttc cgccgcgaac gacccgactc ccccgactcc aagcacagca actgtgctgt 2250241 ttttcagcgt ttcaaggcct tcttttccga tagctaattc attgcgtgaa aactggtgta 2250301 acaagaacct cactccacat tcgtattctg gtttcatcta taaaatggct gatccatgag 2250361 cagccgtttt ttctgcgcac aaaaaataaa gtcccaatag tgccgttgca gctttccttt 2250421 gttttgaacc cgctctcagc aggtgggtgc cctcttttaa atcttgtaag tcctctttac 2250481 cgaatgaaaa gaggcatgta cgccatttaa aaatgcgggc tcccaaatca aaaaaatgtt 2250541 cggtcaaaac taggtgtaca actaacacat caggacttta tttaacttgt caaaatcata 2250601 tcacagacga ttttgatttt caagaatcga actgcaaatt cagttcttaa cttttttctt 2250661 gatagaaaga tgaagctcgt caagctgggc gtcgcttact tcgcctggcg cttctgtcat 2250721 caggcagctt gcacttgccg ttttcgggaa tgcaatcgta tctctcaggt tcgtacgtcc 2250781 agcgagaagc ataacgagac ggtctaagcc gagtgcgatt ccgccgtgcg gaggagcgcc 2250841 gtattcaaat gcttccagca ggaatccgaa ctgttcagcc gcttcttctg gtgagaagcc 2250901 gagaagcgca aacatttttt cctgaatatc cttttcgaaa atacggattg aaccgccgcc 2250961 aagctcatag ccgtttaaga cgaggtcata agcttgcgct ttcatgtctt caggcgctgt 2251021 ttcaatcagc tcaaggtctt ctcggacagg cattgtgaac ggatggtgcg ctgcgtaaaa 2251081 acggccttct tccggatcat gctctaatag cggccagtcg atgacccata agaaattgaa 2251141 caatttttcg tcaatcagtc cgcgttcttt cccaagcttt aagcgcaggg cgccgagtga 2251201 tgcggccaca acttcgaatt gatccgctcc gaacagcagc aaatcacctt cagcagcatc 2251261 aagtgcttca atcagcttag actgcttttc ttcatcaaag aatttagcga tcgggccttt 2251321 cactccgtct gcctcaacct tcacccaggc aagccctttt gccccgtagt ttgcagcaaa 2251381 agcgccaaga gcgtcgatgt cttttctgga gtaatcgccg gcaccgcctt ttacattgat 2251441 ggctttgacc acgccgccgt ttgctacagc tgatgagaac actttaaatt ccgtatcctt 2251501 tacaatgtca gacacatccg tcaaaagcat gtcaaaacgc gtatccggtt tatcagaccc 2251561 gtacttgttc attgcttcgt catacgtcat tcgaggaaga ggaagctgaa gttcctcacc 2251621 ttttgtttca cgcataacct ttgccatcat ctcctcagcc aatgacataa tgtcttcctg 2251681 gctcataaag gacatttcaa tatcaatttg cgtaaactca ggctgacggt ccgcacgcaa 2251741 gtcttcatcg cggaaacagc gggcaatttg ataatatcgt tcaatgcctg ataccatcag 2251801 aagctgttta aatagctgcg gagactgcgg cagcgcgtag aactcacctt cgtgcacacg 2251861 gctcggcacc aagtagtcac gtgcgccttc aggcgtgctt cctgttaaaa tcggcgtttc 2251921 aatatcaaga aacccatttt catctaaaaa gctgcgaaca gctttcgtca cgttatggcg 2251981 cagctgcatc gtctggaaca tagccggtct gcgcaaatct aagtaacggt gttttaaacg 2252041 aacgtcctct gacacttctt cagcttgatc agaaatcgca aatggaggtg tctttgcagc 2252101 atttaatacg ttcactccat cagcatgtat ttcgatcgcg cctgttttca aattcggatt 2252161 aactgttccc tcttcacgcg ccaccacttt tccttgaata tcaagcacgt attcatttct 2252221 gatgccttcc gcaatagcaa gcgcttcttt tgacacatca gggttaaaaa cgacttgaac 2252281 aatgcccgta cggtcacgca agtcaataaa aatcaatccg ccgaggtctc gtcttttttg 2252341 gacccagcct ttcagcgtta cagattcgcc aattgctttt tcagttatat caccgcaata 2252401 atatgttctt ccaaacaatg cgtttcactc cttatccctt ttggtttgcc ttcatcacat 2252461 gtataaattc atcaagtgcc acttcaatct gttcgcccgt ctgtgcatcc tttacattga 2252521 ttttgttttg ggcaagctca tcttcaccca aaatcgcaat aaatctggcc tttaagcgat 2252581 cagctgtttt aaactggcct ttcattttct tattttcata atcgatttca ctggaaatgc 2252641 ctgcttctct cagtttgtac accaatgaaa cagaataatc ctttgctttt tcgccgagtg 2252701 tgacgatata gcagtcgatt cccttatcaa caggcagctc tcttttttca gcatcaattg 2252761 cggcaagcaa gcgttcgatg ctcatcgcaa atccgatgcc cggtgcttca ggtccgccga 2252821 tctgttcgac aagcccgtcg tagcgtccgc cgccggcaag tgtcgtaatc gcgccaaagc 2252881 cctccgcatt gctcataatt tcaaatgcgg tgtggttgta ataatccagc cctctcacaa 2252941 ggttcggatc gatttcatac gaaatgccaa gatcatttaa gtattgtttc actttttcaa 2253001 aataagcggc tgattcttca tttaaatatg tcaaaatcga aggtgccgat ttcatcagct 2253061 catgatcacg gtcttttttg cagtccaaaa ttctaagcgg gttcgtgtgc agccgggact 2253121 ggcagtctga acaaaattct tcgatgcgag gctcgaagtg tttcacgagc gcttctctgt 2253181 agcttttgcg gctatcttga tcgccgagac tgtttatgac aagcttaacg ttttctaaac 2253241 ctgctttttc ataaatactc atcgcaagcg ccattacttc agcgtcgatt gcagggtctt 2253301 tcgaaccaat cgcttcaatt ccaaactgat aaaactggcg gtaacggccc gtctgaggac 2253361 gttcataacg gaacatcggc ccgacataat aaagctttgt cggctgtaca ggatttgcga 2253421 acagcttgtt ttcattaaaa gcgcgaaccg cagcagctgt tccctccgga cgaagcgtca 2253481 ggcttctgcc tttgcggtcc tcgaaggtat acatttcttt ttgtacgata tccgttgatt 2253541 ctccgacgcc tctggcaaac agttctgtat gctcaaaaat cggtgtgcgg atttctttat 2253601 attgataagt gcggcaagtg tctctcataa tttgttcaac aaactgccag cgatctgatt 2253661 ctccaggcag aatatcctgt gttcctctcg gaatgttata tcccataggt agacctcctt 2253721 atgtattcct tataaaatat ccaatgatcg ttaatgatga aaatgaaaaa aactcccgcc 2253781 cctactatac atgatagtag ggacgagagt tatacccgtg gtgccaccct agttggaata 2253841 cgttcatatt cccgctcgat cctttaacgc aggttcacgt tcactgccta atggcgttat 2253901 tcacgcgttc agcaggaaac ctccggagtg ttgtttcgag aaagacgcaa tgggatccgc 2253961 tttcagcctg gggcgggttc ctctctaatc atgcaatctg acctactctt ctccattatt 2254021 ggttcaaatc tttcatcatt tgctatgtac tcaatttcta ttataataat gggattgggg 2254081 ttctctgtca agctttattc cggttgtttt tcctcagcgc tgcttctttg gacataagac 2254141 caaattcaga tgctgtttcc gtaagataac cagtcgtatc gggatctgcg tgatcgctgt 2254201 aatgcagatt cgcttcaccg tcgtgaaatg cacgtcccat ttttggatga tatttcatga 2254261 tttgcacacc tttttgattg tatttacgct tagtataaac aaatcatttt atttttattt 2254321 aaaaatcaga aaggacttta cgatattaaa caagaatgct tttttaatga tcatcagaaa 2254381 ggaggacaca atgaacaaga aatactttgt ccttattgta tgtattattt tcacctcagc 2254441 gctattcccg accttttcat ccgttacagc tgctcaagga gaagcggtca tcgcaacaga 2254501 tgaaatgaac gtcagaagcg gcccagggct tagctacggc attacagcgg aagtaaaaaa 2254561 gggagaacgc tatccaattt taaaggaaga tggagactgg gtgcagatac agcttggttc 2254621 tggagaaaag ggctgggtag tctcctggct tattacaaag gaagaccagg ccagcacaag 2254681 ctcctcagga agcagtgaca ctgtgacatc aacagacccc gatctgcgga tgagaagcgg 2254741 cccgggcact tcctacgaag tcatcggcaa attcccgcaa ggcagccaag catctgtcat 2254801 tgataaagat tcgggctgga tcaagatatc ctatcacagt gccaccggat gggtatcatc 2254861 tgaatatgtc acatcaggag gcagcagttc agcgtctgat gagagtgacc aaaccgagga 2254921 ttccggtgcg tcaacgacgg gcacagtcgg tgtttcttcg ctaaatgtaa gagcctccgc 2254981 ctcacatgac gcggcaatta taacaaaact tgatcgcgga acgaaactga cggttctcaa 2255041 cgagaaaaat ggctgggctc acattgaggt gaacgggcta aaaggctggg ttgcaagcca 2255101 ttaccttttg actagttctg ttccagctga tgattcagca aatgccggca gttcatcctc 2255161 cgctaaaaaa gcctatatca tgtacggagg aacgaatcta agaagtgatg cgtcaacatc 2255221 agcttcgatc gttgagcgcg ctgccaaagg agattcatac accattaccg gttcaaaggg 2255281 aagctggtat gaaataaagc ttgataacgg gcagactgct tatgtagcca attgggtggt 2255341 ccaaacgtct aaaagcgcag aagaagcagg tgaaccgcca gtctctgatt ccccgtctgg 2255401 aaacggctct ctaaacaata aaacgattat tgttgacccg ggacatggag gaaaagacag 2255461 cggaacgatc gggtattcgg ggaaattcga gaaaaacctg acgatcaaaa cggcaaaact 2255521 gctcgccagc aaacttagat cggctggagc ggatgtatat gtgacacgcc aggatgatac 2255581 ctttgtcagc ctgcagtcac gggtctctac ctctcactac cgtaacgctg acgcctttat 2255641 cagcattcat tatgacagct atgcggatac ctctacaaga ggcagtacag catattacta 2255701 cagtcctgcc aaagatcagg aactcgcatc agatgtccac tcagaagtgg tgaagcgttc 2255761 ttccattcca gaccgcggcg tattattcgg agattattat gtgctccggg aaaacagaca 2255821 gcccgctatg ctgtacgagc tgggatatgt aagccatccg caggaagaag ccattgtaca 2255881 tagcaattca taccaagaaa aagtaacaga tgggatcgaa agcggattag agaaatactt 2255941 ccaataaaaa aagctgcctt ttggcagctt tttttatttt gaatccataa tgagcgtgac 2256001 cggtccggag tttgtaagct gaacatccat cattgctcca aacgttccgg tctccacttt 2256061 gattcctttt tcacgaagca ggtcattcca tttttcataa agacctaaag ctttatcagg 2256121 tttggccgcg ttcatgtagt tcggccggcg cccttttttc gtatctccat aaagcgtaaa 2256181 ctgtgagacg gataaaatct ctcctcctat atctacaaga gacagattca ttttcccttc 2256241 actgtcatcg aaaatacgga gattgacaac tttatcggct aaataagctg catcatcttc 2256301 tgtatcatcg tgagtgatgc cgaccagcac cataaggcct tgtccaattt ggccgacgac 2256361 ctcttcgtcc actgtaacgc ttgcttctgt tactcgctga acaactaatc tcttttctaa 2256421 cccctttagt tcatgacgcg gcgcacagaa tagatatctc taatctgttt aatacgctcg 2256481 acgactttat gcaagtgatt gatattctgg ataaaaatcg ccatatggat ggttgccact 2256541 ttattgcgat ccgatttgcc agagacagat gaaatattgg ttttcgtttc attcactgcc 2256601 tggagtacct cgttcagcaa tccgcggcgg tcatacccaa gaatctctat ctcaacattg 2256661 tattccttgc gcttttgaac ttgtgactca tgttcccact ctaccgggat cagccgctct 2256721 tgggcttcat tcgttttgac attcggacag tcttcgcgat ggaccgaaac ccctctgcct 2256781 tttgtgataa agccgacaat atcatcacct ggcacaggat tgcagcattt tgataaacgg 2256841 acaaggaggt tgtcaatgcc cttgacacga acgccagctt cccgttttct tccttgcggg 2256901 tatggcttag gttccccagt gacttcctga acgatctttt cctgttcttc ctggtcgcgc 2256961 tgctttctct ctttttctgt taggcggttc gccacctgca gagctgtgat gccgttgtaa 2257021 ccgaccgccg cgtacatatc ctcttcattt gagaaattaa atttgtcagc aaccttttga 2257081 atattctccg gcgttaaaac atccttcaat tcaaaatcca agtttttaat ttctttttcg 2257141 accagctcac ggcctttttc gacattttct tcacgccgct gtttcttaaa gaattgacgg 2257201 attttatgct tcgcttggga tgtttgggca agcttcaccc aatcctggct cggaccgtag 2257261 gaatgcttag aggtgagaat ttcaacgata tcacctgtcc gaagcttatg gtcaagcgta 2257321 accatttttc cgtttacttt ggcaccgatt gttttattgc cgatttcaga gtgaatccgg 2257381 taagaaaagt caatcggaac agaaccggac ggaagctcga ttacatctcc ttttggcgta 2257441 aagacataca ccatgtcaga gaacaaatca attttgagcg attccataaa ttcttctgca 2257501 tctgtcgatt cattttgaaa ttctaaaatt tcacggaacc aagaaagctt tttctcaaag 2257561 gttgcacctt cattggctgc tttcccttct ttataagccc agtgagccgc aaccccgtat 2257621 tccgctattt catgcatttc aaaggtgcgg atctgcactt caagcggatc gcctttaggc 2257681 ccaataaccg ttgtatgaag cgattgatac atattcggct tcggcattgc gatataatct 2257741 ttgaatctgc ctggcatcgg tttccagcat gtgtgaatga tgccaagcac cgcgtagcag 2257801 tcctttatgc tattcacaag aatacggaca gccaacaaat cgtaaatttc attgaattgc 2257861 ttattttgca gcaccatttt tcgataaatg ctgtaaatat gtttcgggcg tcccgagaag 2257921 tcagccttga tatttacttc ttcgacacgt ttcttcactt cattgacaac ctcatcgaca 2257981 taaagctctc gttctgcacg tttcttcttc atgaggttga caattctgta atattgctga 2258041 gggttcaaat aacggagcgc cgtatcttcc aattcccact taatttttga aatcccgaga 2258101 cgatgcgcca aaggagcaaa aatttccagc gtttcattgg agattctccg ctgtttttcc 2258161 tgaggcagat gtttcagtgt ccgcatattg tgaagacgat ccgccagctt gatcaatatg 2258221 accctgatat cttgagccat agcgacaaac attttgcgat gattttccgc ctgctgttcc 2258281 tcttgagatt tatatttaat tttgccgagt ttcgttacgc cgtctacaag cattgccact 2258341 tcttcggaaa atgcttcttt caggtcatcg agcgtcacat ctgtatcttc cacgacatcg 2258401 tgcaaaaatc cgcccgcgat tgtggaaggg tccatttcaa gatcaacgag tatccccgca 2258461 acctgaatcg gatgaataat atatggctcg cccgatttgc ggtattgctc gcgatgagca 2258521 tcttcagcgt acagatatgc tttttcgaca aatgcgatat gctcatcaga tagatagctg 2258581 cgtgctttat ctataacttg ctcggcagtc aatacttgtt cgttcgccat ggaatcacct 2258641 tttttaaaat gtaaactgta ttgtagttta ttatcaagaa aaaaacgaaa gatgtaaaga 2258701 gcagaagttc aaatagccaa atattatata aaataaatgc aaaacaatag gaaaaaagca 2258761 ccctgacatg gagtgctttt tcgttatgcg gttatcctta gtatttcatc aatgttaaga 2258821 tgtcgtaatc ttcgagctta tttctgccgt caaggtaaga aagctcgatt aagaaagcga 2258881 taccagcaac aacgccgcca agttcttcaa caagtttgat tgtcgcttca attgtgccgc 2258941 ctgtcgcaag caggtcatct gtaataagca cacgctgacc aggcttaatc gcatctttgt 2259001 ggatcgttaa tacgtctttt ccgtattcca agccataatc cactttgatt acttcacgag 2259061 gcaacttgcc ttctttgcgg accggcgcaa aacctacgcc aagcgcgtaa gcaacgggac 2259121 agccgataat aaagccgcgc gcttcagggc caacgaccaa atcaatttgc ttttctttcg 2259181 catattcaac aatttgatct gtggcatagc ggtatacatc gcctttatcc atcagtgtcg 2259241 taatatcttt aaattgcacg ccctctttcg ggtaatccgg tacaattgtt acgtattgtt 2259301 ttaaatccat ctgttttatg tcctcctcgt actttcataa gcctctgaat cttgtttcat 2259361 cagcttattc agccattcct tcagctcttc agcagaagaa taattcagct tttgatccag 2259421 ttccatcagc tgctgtttcg cctgatatgt ttgtgagtct gttaagtcgc gtttctttgc 2259481 tccgctcaca acagacagca caccattctc tattttaaca aaaccgagat caaaaaacac 2259541 ctttgtcatg aaattgattg tttcaacgga ccagccttta tgttttgcaa gctctgaacc 2259601 gtgttttttc acgtcaaaag cgcctctttt cagcaagaac gcataatacc atttaaagtg 2259661 gtctcttgcg ggaaaagttg ataaaaagtg gtcctcatga ttgagaaaaa taaaatatat 2259721 ccgctcgggc gcctttcctt ccagcaaacg tgcgagcatg tccagcgaag gcggcggatc 2259781 cagtaataca atatatgcac catcgaggtc aaacgccttt gcttgatctt tagaactgat 2259841 gacgtgcact tctcggcgaa ggtcttcagt ttgaagtaat gttgttgagt cttctttgaa 2259901 agagacaatg gcccgtttag cagatggaag ggcggaaact gtgtcttccc acgtccgttt 2259961 tccccttaaa tcaaacagct gccattcaga aacagcggca tcctttatca taagctgcgg 2260021 cttttttcga ttgttccatt cgttgattga catctcaccg acaatggaaa ttcttgaacc 2260081 cggtacgatg ccttcttgaa gctcgccttt attaaaaccg acgcaatcaa gctgggacga 2260141 ctcgtttctg atcgtcattt tgacatgagt tttatttgcc cctatcttgc ggacatcttc 2260201 cagtactgca ttttctacga gaacgtgcgg tttcgggttc agcatgccaa aaggagacag 2260261 catgttcatt tctgcgatgc tttcaactgt aatgtcttcg acgccgcaga caaggtcgac 2260321 ttcctgtacg ggaataaaat cctcttccgt aagcgtattg tccgctattt cattcagcct 2260381 gcttcgcaaa tccggcacat cttcggcttt cagcgtcatc cccgcagcca ttggatggcc 2260441 gccgaaatga ggaagaatat ctctgcattc agaaaggctc tcaaataaat taaatcctct 2260501 gatgcttcgg gccgaacctt tagcgattcc cttttcttca tcaataccaa gaacaatggc 2260561 cggtcggtag aaacggtcca caagctttga agccacaatc ccgacgactc ccgggttcca 2260621 tccggctttg gccacgacaa ttgcagtttg atcgagccct tgctgttcaa ccatttcaat 2260681 cgcttcatcc gtcattttgc tgaccatttt ttggcgctct ttgttcagct ggtcaatttc 2260741 tgcggcaagc tcttccgctt caaacgaatc ctctgacata agcaaatgaa cagcgggatc 2260801 cgcctgttcg attcttccga cggcattcag ccttggtgcg agctgaaatc cgactgtttc 2260861 ttcgttcgct tctccgatgt ctccgcctga cagcttaatc agctctttta agccgagccg 2260921 atttgtccgt cgaagccttt caagtcctag tgttgctatt aatctgtttt cgtcatgcag 2260981 cgggactaga tcggcaatgg tgccgatagc cgccaggtca agcagttcat caggaagttc 2261041 acccaataaa gcgtgggcaa gcttaaacgc gactccaacc ccggcaagct ctttaaacgg 2261101 gtaagtgcag ccaggctgct tcgggtggac gatcgcacgg acatccggaa gctccggtcc 2261161 cggttcatga tgatcggtaa tgatgacatc cagtccgagt tcctttgcca ccttcgcttc 2261221 atgcacagcg gcaattcctg tatcaaccgt aatgatcaaa gagaagcccc gttctttaat 2261281 cgaacgaaac gcctgttcat taggtccata tccttcttta aaacggtcag gtatataaaa 2261341 atcaacttga gccgacagtt tttgcagcgt gtgaagcatc actgacgtac ttgtaacccc 2261401 atcggcgtca taatcgccat atatcataat cttttcttgt tgtgaaatcg cctgttttat 2261461 tcgatctgcc gcttctttca tgcctttcat ttcaaaagga tcataaaaat cggcatcctt 2261521 tgtatgtaaa aacagcctag cgctttctgc cgtatcaaag cctcttttta caagcaggga 2261581 cgcaacaaga ggtgttatat gcaattgttc tgtgagtgat ttgaccttat cctgatctgg 2261641 tcgctggatt tcccatcgca tttttgacgc taacataaat tcacccctca accaccctat 2261701 tatactagag caggctgagg ggtttcaaat aatattcgaa aactagtctt ttttctcaat 2261761 catggctgat gcatcctgtg tgtcagtctg atcagcaaga tgagtatcct cttgtttatg 2261821 tattgctgtt ctattttctt tccgcaaggt ttttatttcc cgcttcaatt tcattacctg 2261881 aaaaatgccg acagaaaata cgatcagtgc tcccattaaa actgagccca aaataacaag 2261941 aatgagcggc cattctgatc ttccaaacag gtaatcaact tctacggatc gaacattaat 2262001 gactgcgaaa atagcgacaa ttaaggtgaa aataagtgcg aaaataatgg tccattgttt 2262061 attcattctc ttttccccca aacttcttat tgaggtaact ttcccaatca agactggttt 2262121 taaacatggc ttaacactag gttaagctcc ctttgctgtt aatttttccc ggatcagcct 2262181 cttcagtccg gttccctcac cggaaatcac aagtgtatcg ccttcgtcaa tgactgtttc 2262241 agagctcgga ttcagttgtt tatcctgatt ctttttaaca attgcaatga ccgtcacatg 2262301 atattcctga cccacattca aatcaccaat cgtctgatga atggcaggcg ctcccgcctc 2262361 tgctttacac cactctataa tcaaatcatc aagggctgac tcgacctgtt ctaatgcttt 2262421 cggtttatat gccattccgc caagaattgc agacatttgc cttgcttcag cgtcatcaaa 2262481 ctgcacggag gcaacacatt cctcatggtc gttttcgtca aaatagtaaa gctctctccg 2262541 tccgtcatga tgaatgataa ttgaaatttt atcacggttt ctagtaatca tttcaacttt 2262601 ttgtcctatg cccggcagct ctgattcgcg aaccctcata tataaaccct cctacatatc 2262661 tgaaaaccag ccataaacac ttttaacacc atatatatgt ttaaatgtaa gcgtatgtca 2262721 ttatagcaaa tgtctatttt aagttcaatg aaacttcaaa aaacaggctg ccctgcagag 2262781 gacagcctga tattttttat tgcgccgaat cttttttcag ttctcttcct ttccatgcaa 2262841 gccaaatttg tgcggcaatg tatagagaag aataaacgcc tgttaacagc ccgaccaata 2262901 aagcaattga gaagttagta atagaagatg ctccaaagat cagcaatgtc acaacaacaa 2262961 tcacaacggt taatacagtg ttaattgaac gtgtaaaggt ttgctgcagg ctcaggttta 2263021 caatatggtt cagatcggca aaggttttcg gcttacgctt tttcatatgc tcgcggaccc 2263081 tgtcaaatgt aacgattgta tcgttaatgg aatacccgat tatcgtcaag atggccgcga 2263141 tgaatgtaac atctacctca agccttgtaa tactgaagaa cgtgacgata aagaatgcgt 2263201 catatagcaa tgaggcgatg gcagcaatcg ccattttgta ttcgaatcgg attgaaacgt 2263261 aaataatgat gccaatagaa gctatagcaa ctgcgtacag cgcatttctc gccagctcct 2263321 taccgactgt cggtgaaact gtgctgacat ttggatcaga tccgtatttg tctttaaaat 2263381 acgtttttac ttttgcaatg gtttctttat ctggcacccc gacaaaacgg gcaacaccga 2263441 tattgctctt ttcgcctgac agaactacag tatcagggtc catacccaga gattcaaaat 2263501 ccttctcaac ttgctctgtc gtcagcttat ggtcgctttg cacttcaatc cgtgcaccgc 2263561 ttgcaaagtc aatgccaaga ttcagcctga acacaagcag gataataatc ccggcaaccg 2263621 tgaccgcact ggagaaaata aagaagtatt tgcgtttgct cgtgaaatcc catttttgga 2263681 atggcgtatg cggctctgta ttttcatccg tatcctgaat atccatgata tgtttcttat 2263741 tgacaccaaa ccagcctttt ttccgatcaa gccatctgct ttccacaagg agagcgagga 2263801 gaaatctcga taagaaaacg gcagtgataa agcttgtcaa aatcgatagg atcagcattg 2263861 tcgcaaaccc tttaacagag cttgtcccaa agataaagag cacaaccgct gcaataatgg 2263921 ttgtaatatt cgcgtcaaaa atcgtcgcaa atgaccgtct gtttcctgaa cggaaggcag 2263981 agcggactga ctttcctagc ttgagctctt ctttaatccg ctcataggta ataatgttgg 2264041 cgtcaacagc catcccgaca cctaaaatga gagcggcaat tcccggaagc gtgagtacgg 2264101 cattcatcca gtcaaagatc tggagtgtaa tgtagatata aacagacagc gtaatcaccg 2264161 cgattaatcc cggcagacgg taatagaaaa gcataaataa gaaaataatt gcgataccga 2264221 caataccggc aaacaccgta tcatggagag cctgctggcc gaattgcgcg cctactgatg 2264281 tcgaatactt ttcagtcagt ttcacaggaa gtgcgcctgc gtttaaaatg ctggctaaat 2264341 ctttcgcttc ttgagctgtg aaatgacctt caatttttac atcagttgta tttagttcct 2264401 gacttacatt tggagcggat acaaatttag gatgctcttt ttgaacttct ttcttaaagg 2264461 aatcaccttt atcataatcc aaccaaatga caagctggtt gtttggcgcc attttcatga 2264521 ccttcttggt cacttcacca aatttatcag cgtctttcag cttaatcgtg acaattggct 2264581 catttgttgt gctatcataa gtttgtttag cgccgttttc gactagatca gcaccgttta 2264641 acagttcctt atcatttgca tctctgaaag aaagctgcgc ttcagtcgcc aaaatttcac 2264701 gcgctctgtt ttggtttgtc acgccagcga gctgaacgcg aatccggtta ttcccttcaa 2264761 tttggatgtt cggttcgctg acaccgagaa cattggcccg gcggttcagt gcctctactg 2264821 tgctgaccag aacgtctttt gtgattttgt cacctttttt tacaggctgt acatcataca 2264881 gcacctcaaa tccgccttgc aaatccaatc ctaacgtaat attgttagcg gcaggcttcg 2264941 taaagtagcc caagcccgtg ccgatcaata gaacgaaaag gaaaaacgca atcaagcgtc 2265001 cttttttcat tatgtatatc ctcccttaaa cctgtgcgaa tcaacctgct atctcagcag 2265061 ttcttccaat gcttcctggc cctcttcact gcccagccaa ttagacgttt taaatgactc 2265121 aacggttgca tagttcataa attcgccaat tttcactgat aaaatatcac tcgccagttc 2265181 ataaatgctc agttccgttt tctttttcca cttcttatct gttaagtatg accacaaact 2265241 ttcgagttca acatcatcat acccgagaat cttaaactct tccagtttgc tgtaaagaaa 2265301 cggcctgacg tggtctttat atagatcggc tggatgcttc tccacgaatt ccacgctcct 2265361 tttttattgt ttttcaagaa gacttgtcat gcttggacga catatacgca tatctttatt 2265421 gtatatgatt ccaggtagtt tgagaaggca gggggtaaaa atggcgaaac agacgttttt 2265481 aaagggcact cttatcctta tcgcagcagg aatggttaca agaatgctcg ggtttgtcaa 2265541 ccgggtggtt atcgcccgtt ttatcggtga agaaggagtc gggctttaca tgatggcagc 2265601 gcctactttc ttcttggcca ctacattaac tcaattcggt ctgccggtcg cgatcagcaa 2265661 gctagtcgct gaagccagtg cgcgcggaga tcatcaaaaa acgaaaaata ttttagtcat 2265721 gtctctgacc attacgggag tgctcagcct catctttaca ccgctgtttc tgtttttcgc 2265781 ccctgttatg gctgaaacga tgctgacaga taagcgaaca ctgtatccgc tcttggccat 2265841 tacgcctgtt gtgccgatta ttgctatatc gagtgtgctg aggggatact ttcaaggaaa 2265901 acagaatatg aacccgcttg ctatgtcaca agtccttgaa caggttgtcc gcatttcact 2265961 cgtggctgtc tgcacaacga tttttctccc ttacggaatt gaatatgctg cagcgggggc 2266021 aatgctatcc tcagtggcag gggagctggc atcacttctt tatttattcg tttgctttaa 2266081 gtataaaaag acaattaaaa tcagaaagca ttttttacag tcaattaaaa acggaaaaca 2266141 aacctttacc caattaatga gcgtgtccct tccaacaacc gggagccgct ttatcggaaa 2266201 cctctcttgg tttttcgagc caatcgtcgt cgctcaaagc cttgccatcg ccggtgtggc 2266261 aacagttgcc gcaacaaagc aatacgggga actaaccggc tttgccatga cgctgctgac 2266321 tctgcccagc tttattacat attctttgtc gaccgcgctt gttcctgcga tcagtgaagg 2266381 aatggagcag aaaaaattgc aggtggtgga ataccgctta gaacaggcga tgcgtctctg 2266441 tctgctcagc ggaggcattt cagttgttat tttatttgta tttgcggatg agctgatgag 2266501 agtgatgtac ggttcctcag gcgcagctgt atttataaaa gtgatggccc cgttttttct 2266561 gctttattat ttccaaggcc cgcttcaagc tgtgctgcag gcgcttaatt tggcaggagc 2266621 tgcgatgatg aacagcttaa tcggagcgct tgtcaaaaca ggccttattt ttgtccttgc 2266681 cacaaggcct tctcttggca ttatgggcgc ggcattagcc attgtgacag gcatggtgct 2266741 cgtcacgcta ttgcacgcag caaccgtaag caaagtgctg ccgatcagca tcaaaatcaa 2266801 ggagtacgcg ctcagcttcg ctgttattgt aatttgcgga ttcatcagct ccgccatcaa 2266861 acaatatata agctttggag catctgaggc tgtcaatcta gccggatgga ttgcggcgag 2266921 cgccgccatt tatatgatcc tcctgctcgt tttccgttta attaaaaaag atgagcttcg 2266981 ccgcattccc attatcggac ggttgatcat ccgataatgg tcacgtgcgg tgcccatctt 2267041 tttcatcaat atatatttct ccgtctgtaa acgagcaaaa tgaaatatct gaagggtttg 2267101 tgtatccgtg tttttgcaaa ctttcaagca gccattttct atctttactg attctggaca 2267161 ggttttctgt ttgaatgaag ccgtctataa tgagcggcat ttcgagctgc cgatgctctc 2267221 cgctgttttc tttcttaaca atagtcagtt tgcccgacgg ctctaaaata gcaaatgata 2267281 cgtcagctac tctgtcgatg ctattttctc tgagctgaac cattaaatca tcaaaattat 2267341 aacgctgtga tttcatggct tcttcgtcaa tttttccata tttgataatt atggtcggct 2267401 taccgtcaag aagctggcgg acttttcggt tttttaaaga aaagtatgcc aaagtcactt 2267461 gaatgatcat taatacaagc attggcaaaa tggtatgaaa tagatgatcg tctacgtttt 2267521 ctatggctaa aacggcaatt tcagccatca tgataaagac aacgagatct aaaatactaa 2267581 gctctccgat ctcccgtttg cccatgaaac gaaaaatgac caatatcaca aaatacaata 2267641 cgactgtgcg aaacgcaata gtgagaagct cttccattat gcacctccaa ctcattatag 2267701 gttgcaacaa aatgatcaat ttatgtaaga aaaaccgatt gcatttcaca aagcttttac 2267761 gtctaattca tgggataagg gaatacattt ttacaaagac gagccatcag catgtctgac 2267821 ggttttgaac aaaaagaaca gaagcctttt aatacaggca gagaggagac aatcatggag 2267881 gaaacgaaac aagttggaaa aggcattctt tacggcttaa tcgccatatt ttcagccatg 2267941 ctcctgacaa gtttagcggt ttcactttta ttgaccgcaa cctcgctgga agaatcatca 2268001 tttaactggc tgatcaccgc tatctcattt ctctctttat ttatcggcgg gttcatttca 2268061 ggcgggaaag gcaaggaaag aggctggatg attggcgcat tgaccgcctt aagtttttct 2268121 ctgattatct tattgtttca gtatttagga ttcggaaaga catttacagc agaacagctg 2268181 atcttccatc tgggattttt aggggtgtgc atgctgggcg ggattttcgg cgtgaacatg 2268241 aggggaaaca ggtcttccac ataaaaaaga gcgggctcac ttgcccgctc ttttttgttt 2268301 gctatgtata gctcctgctg ttattcagca gcagaaactt ctctgatcgc gcggcggtcg 2268361 aacgtaagac gtgtgttatc accagtctta attacgactt tgctttcgtc gatagagtca 2268421 acagtaccgt gcaatccccc gattgtcact actgaatcgc cttttttcag ttcctcttgc 2268481 atttggcgta cagccttttg ctgcttttgc tgaggacgaa tcagcaagaa gtaaaggacc 2268541 gcaaacatta aaataatagg aaccaatgta cctaaagtgc cagtcatcat tttcacccct 2268601 ttctgtaagc ctgttatgtt tatttagaag cttttcgcat ttggcttgtt atagccgtaa 2268661 cgctcaaaga actcttctct gaaatcaccc agacgatcct cgcgaatagc ctgtcttacc 2268721 tgctccatta agtgtaacag aaaatgaagg ttatggtaag ttgttaatcg aaggccgaat 2268781 gtttcattgc agcgaatcaa gtgcctaatg tacgcgcgag tgtagttttt acatgtatag 2268841 caatcacact cttcatcaat cggacggaag tctctttcaa atttcgcatt tttcatattg 2268901 agtcgtcctt cagcagtaaa cactgtgccg tttcttgcaa tccgtgtagg cagcacacag 2268961 tcaaacatat cgaccccgcg gatcgctccg tcgatcagtg cgtccggaga acctactccc 2269021 atcagatatc tcggtttatc cttcggcaag agcggtgttg tgaattcgag tacacggttc 2269081 atgacatcct tcggttcacc tacagacaat ccgcctatag catatcccgg aaaatcaagc 2269141 gaaatcaagt ccttcgcact ttgtgtccgc agatcttcat attctccgcc ttgtacaata 2269201 ccaaacagcc cttgttcatc ctgacgattg tgggcattca ggcagcgttc cgcccagcgg 2269261 cttgtccgtt caactgacct cttcatgtag tcgtactccg ccgggtatgg cgggcattcg 2269321 tcaaacgcca tcataatatc agagccgagt gcgttttgga tctccatcgc tttttccgga 2269381 gataaaaaca gcttgtctcc atttagatga ttgcggaaat ggacaccctc ttcctctata 2269441 ttacgaaact tgcttaaaga aaagacctga aaaccgcctg aatctgttaa aattgcgcgg 2269501 tcccagttca taaatttatg gagcccgccc gcttctttga caatgtcttg gcccggacga 2269561 agccatagat gataagtgtt gctcaaaatg atgcctgcat ccattgcttt cagctcttca 2269621 ggcgacattg ttttgactgt cgccagtgtg ccgaccggca taaaaaccgg cgtttcgaag 2269681 gagccgtgag gcgtatgcac tttgcccagc cgcgctcctg tttgtttgca ttcttttata 2269741 aattcatagc gtattggttg ttcagccact tttgatgagg cctcctgttc tcaaattata 2269801 taatcagcat cgcgtctccg aagctgaaga aacggtattc ctcttccact gcatggttat 2269861 aggcacgcag aatgttttct cttccagcaa gcgcgctgac cagcataatc aatgacgatt 2269921 tcggcaaatg gaagtttgta atcattccgt caatggcttt aaattcatag cccggataaa 2269981 taaaaataga tgtccagccg cttgatgctt taaattgccc gtcatgttct ccggcaatcg 2270041 tctcaagcgt gcgtgtcgag gtcgtgccga cagaaatgat ccgaccgcca ttttctctta 2270101 ctttgtttaa ggctgcagcc gtttcttctg acatttgata aaactctgca tgcatattat 2270161 gctcttccac ttcatcggca ctcacagggc gaaacgttcc aaggcctacg tgcagtgtga 2270221 tgaactcaat ttgcacgcct ttgtctttca gctgctgtaa gatttcttcc gtgaagtgaa 2270281 ggccagctgt aggcgcagca gcagagccaa tttcttttga atacactgtc tggtagcgct 2270341 ctttgtcatc aagctgttct ttgatatatg gagggagcgg catctctcca agggattcaa 2270401 gcacctcgta gaaaataccg tcatattgaa attccatctt tctgccgccg tgctcaagct 2270461 cttccgtgca gattgccttc aatcttccgt ctccaaatgt gacaacagtt ccttttttca 2270521 cccgtttcgc cggtttggca agtgtttccc atttatcacc ggtttcctgt ttcaacaaaa 2270581 gaagttccac tttcgcgccg gtatcctctt ttgtgccgaa taaccgcgca ggcagtaccc 2270641 gggtattgtt caggactaga caatcgcctt cgttaaagaa gctgataatg tgtttaaacg 2270701 agctgtcagt aagctctcct gtatgtttat cgagcaccat cagccttgaa gcatcacgct 2270761 gctccaacgg tacttgtgca attaaacgtt ctggtagttc aaaatcaaat aaatcgactt 2270821 tcatgatgat ttcaccttta ttctagtctt ttgttatttc attctgccaa aaagattaag 2270881 caaaattgat aataccacac ttataataat acaagtgaca accgggaaga aaaacgtaac 2270941 atttcctttt tttacaaaaa tatctcccgg catcttgccg acaaaatgca aaactgctcc 2271001 gataataagc aaaacagcac caagaatcat aatgatctta ggaaattcag tcatatcggg 2271061 gagcctccat ttggaaatga tgataaacgg ccggtgtcac gatccttcca cgcggcgttc 2271121 tttgtataaa tccaatttgc agcagatatg gttcatatac gtcttcaatc gtatgcgatt 2271181 cctcgccgat ggtagctgaa atcgtatcaa ggcctactgg gccgccgttg aatttttcga 2271241 tcatgcccat cagcagctta tgatcaatat gatccaaacc gaggcggtca acctgaagcc 2271301 gctccagcgc attctgagaa atgtcttccg taatcctgct gtcacccagc acttgggcga 2271361 aatcgcgcac ccttctcagc aggcggttcg ccacgcgggg cgtccctctc gatcttcttg 2271421 caatttcaag agccgacggt ttatcaatct caacctcgaa tacatcagcg gttcttgtga 2271481 caatatccgc cagttcttct tgtgtatagt actcaaggcg agacattacg ccgaatctgt 2271541 ctcttaaagg agccgtcaaa agccccaccc tcgtcgtggc tcccaccagc gtaaaaggcg 2271601 gaaggtcgag gcgaaccgag cgggcagatg ggcctttgcc aatcacaatg tccaggcaaa 2271661 agtcttccat tgcaggataa agcacctctt cgatcgatct gtgcagccta tgtatttcat 2271721 caataaataa tacatctccc ggttccagcg ccgttaatat agcagccaaa tcaccaggcc 2271781 tttcaatcgc aggccctgat gtcgtccgca attccactcc catttcatta gcaacaatcg 2271841 aagcaagcgt tgtttttccg agtccgggcg gcccgtacag aagaacatga tccagcgtct 2271901 cctgtctcat tttcgccgca tctataaaca cgcgcaaatt ttcttttacc ttatgctgcc 2271961 cgatatactg tgccagattt tgcggcctca ggctttgctc tatcactgat tcatggttgt 2272021 ctgcttcact tgagacgagc cgttcatcca tgaacatcac cttactttaa tagtttttgt 2272081 aatgcttttt tcacatattg gtctgttgtc agcccaattt cttctttaag gtgaggaagc 2272141 acctttttga tttctttttc agcatatccg agaaccctga gggcttcaag tgcttcttca 2272201 agagccgttt ccgctgtttg cttttcaagc ctttcttcat gattaaacag attttcaatc 2272261 atttcaggca caacatctgc cagctttcct tttaaatcta gaataatctg gcgtgcggtt 2272321 ttctttccta ctccaggaaa cttgaccaaa aaagcttcat cttcattttc aattgcttgg 2272381 atgaccgctc cgggatcacc cgagcccaag atggcaagtg ctcctttcgg gccaattccg 2272441 gtcacgttta acagctttgt aaagagcgcc ttctcctctc ttgttgaaaa accataaagc 2272501 gaaaaagcat cctctctgat atgatggtat gtaaaaatcg tttcttggct tctctcctta 2272561 tatataaacg gattcggcgt gaaaatctga tagccgatgc cgccgttctc tatgacaata 2272621 tattggggag atacataatc aatcgtccct ttaacaaatt caatcacgca aattcacctc 2272681 tttgactgtt cttcattgta ccataaaaac agccaaagtc ttatagaaaa gttaacatat 2272741 gttcgcttct ctctcattct ttcacgaaaa aaaagacatg aatacatgtc ttcaatcagc 2272801 ggacgctacc cgctgtatgt cttcatatgt tcgatgacat cctcaaactc cgcttttgtc 2272861 cgaaatggaa tgcctttcag cagatttttt tgcatatggc tttccagcct ttctaaatca 2272921 atttgaaaaa aagactgaat tggttcggaa gctggctcag gccgcccatg aaaagtggaa 2272981 atcactccat tatccgatac accgatatac ccgttgacct tgctgagcgg agaaatatcg 2273041 tccatttgct tccggaagag cacatatccc tttttttgtt ccactagcgt ccatccggca 2273101 taagctgccc aaaaatcatc catagaaaac actttttcat gcttatgctc aatgctgaca 2273161 tcgccgtcca aatacacctt ttcaagctgc acatgcacct gcagcggctc atagtgctcc 2273221 acttccgcgc caagtgcgcg ggaaggagct cctattaaaa atactgccgc tgagcaaaga 2273281 atgcccagca aaagatacgc cgtgctgaat cgtttcaccc tctacacctc tttgcacacg 2273341 tttatgatta gtttgaccaa agaggctact gcttaaccgt tttatcaaaa tttgtctgca 2273401 cattttccct gacaaaccgt tcctccgtat acacatctgt gctttgctca gaaattgtca 2273461 agaatcgcgt cagaaaggca ctgaaaaaat acaatgccgc aaagatccaa atcacgccac 2273521 ctgcaccgag cggcccaatg aaaagactca cgatgcccgg cgcgataaac gcacataaac 2273581 cagatcccaa attcaacact gacatggcag cacctttatt atcaggtgca agcgtcggca 2273641 aaagcgcgct taatgggacg taccctgcta aagccgcgcc gtagcagcag gcgataatca 2273701 tgagcaccca atactgatgc ccgatcagct gaggcgtgta atacagcgcc agcgtaaaaa 2273761 taccgcatcc gacaccgcca aaccacatga ccgtattgcg ccagcctagt ttatctccga 2273821 ctgcaccgaa aatgatatta aacacaatat tcacaaaaaa cagcgtcccc catatttgca 2273881 gccattccga aaccgaatac ccgtatcgtg ctaaataagt aggaagaaag atggcaaatc 2273941 caaattgtcc tatcgcatta atcgtcttga ccactccgcc gatgcctacc ttagggtttt 2274001 caaacataat cgtaaatgcc ttcgacagtt ctttccattt cggctgatct tgtttttgta 2274061 tcggagtaaa tttatctttg ttaaaaaata aggcaagaat tccgcctgcc gccacaaaca 2274121 gtaaagcgct ccaaagcgta ttgatttctc caaaggccgg aactgcatag ctggaataga 2274181 acggaccgag cacgttaagg ccgcacgtaa acataaacca aaaccagccg acggcttttc 2274241 caagaatatt ttgagaggtg ctgtatgaca cccatacgag aaaagagtat gcaaacagcg 2274301 gatatcccaa gcctctaaga gcatagctgc ccaagagagc cggataatac atatgaggaa 2274361 tcgcccagcc gataaaagcg gccgaaccga ggataaatgc aagcaatccg acagtcatcg 2274421 tttttctcgg cccccaagtt tggacaaacg ttcctgaaag ccaagctgag atggtgacag 2274481 caatgccgta catggtaaat aacgatgcgg attgctgcat actgagacca tgatcaacga 2274541 gaaaaggaga cagccagcct tgttcgaggc cgtctccaac cataaagatg acaacgccaa 2274601 tataacccca aaccatgtga gaaggaattc cgattttgtt caaaacattt cctttagcat 2274661 gtactgtatt cattttctcc accgcctact taaagtatca atggagtata tacccaagct 2274721 tgctgaattg taatcctgtt agattaaaaa gcgatttttt cagtgtgctc aatgctaaca 2274781 ggcatgccaa aagcaagcga ttgctgtgct gctctggcga tcctcccggc ctgtaaaccg 2274841 tcattgccgg tgcagggagt ctcctggttt gtgccgatcg cttctgcaaa acggagaatc 2274901 tcctcctcat atgaatcctt atagcgttca aggaaaaaga aatgcggttt atccttcatc 2274961 acaaaatcag ctgttgacac ctcaaccgtt gtcggcctgc tattgtcagc cgctgcagag 2275021 cctttcgtcc cgaaaacctc aacccgctgg tcatatccgt acacagcttg gcggctgtta 2275081 tcaatcacag ccatggcacc gttttcaaaa gtcagtgtaa taacagctgt atcaatatca 2275141 cccagctccg caaaagaagg attcaccaaa gccgcccctt tggcatacac ttccgtcact 2275201 tcgcttccca taatatatct ggccatatca aaatcatgga tcgacatatc cataaacaat 2275261 ccgcctgacg tacggacata atctatattc gggggttctg ggtcccggga cgtgattttt 2275321 aataaatgag gtgtaccgat ttcaccattt tcaacaatcg ttttgatttt cttaaaatga 2275381 ggatcaaagc ggcggttaaa tccgacttga agtgttaccc cgtgtttccg gacagccgca 2275441 agcgcttcac tcgtttcgtc cagagagaaa ctaacgggct tctcacaaaa tatatgcttt 2275501 ttcgcctcgg ctgcttcttt gatcatctgt gcatgtacgg ctgtaggaga gcaaataaaa 2275561 atagcatcaa tatcaggatc atgtaataaa tcacgataat cagaggttat gtattcaatc 2275621 tgatgactgt cggcccagct ttttatacgg ctcgcctgaa tgtcagagat tgcttttatt 2275681 ttcatgtgag gaatccggct tatattttga acatgaagtt tgccgatgcg gcctgcaccg 2275741 ataatccctg tcacaatctg ttttgtcatg gcttcttccc ccttgatcat tcacgaaagc 2275801 gctttattta aaattaatac tatcccattt gtaagcgctt ttcaagaatg gaaattaaac 2275861 gttctatgtc tcttttatca caattcatgc ttataagtag ccttcttctt caagaccaga 2275921 tacactagaa ttaggctctt tttcctgaac agtttatgat tttcctataa acagctgcat 2275981 aaaatagagc aaagaaggtg aatgaaatgc tgacaaaagc agaggcactg gcccataccg 2276041 tcatataccg caagaacagc agatttgata aagtcaaaga gaaatccgag gaattaacac 2276101 taatcggcaa gggaagaagc gcctatgtgt ttgccttaac agaaggcggt cgaaaaatgg 2276161 cgctgaaagt attttttccg gaatatcaag cgacagcagt caaagaagca gcgatctatg 2276221 aaaaattagc cgggtccgca ttctatcctg acatttacga aactggcgat tcatttattc 2276281 tcatggaata tattaaaggt gaaacctttt ataactgtct gaagaaaggc attgcaatca 2276341 gtgatgacat gattcagcag gttgaagaag cgctttctga cgcccgggca gccggactga 2276401 acccgtcaga tattcatttg cggaatctga tattgacaga aaccggggcg gtgcgggtga 2276461 ttgatgttgc gagatttgag cagacaaaaa catgcacgca gtgggacgac ttaaaatccg 2276521 catatcatgc actctacaaa aaaccgatat tccccaaaaa gattccgggt ttttggctgg 2276581 agatcatcgc atttttatat aagaaagatt ggtttcaaaa gcatttcgca cagcggaaaa 2276641 gaaaatattc ttaaatcaaa aaggcagccg cacaagcggc tgcctttatc atgtattttt 2276701 tactttctga cggcagaaat cagtttcatt tgttcaggcg acagcttaat tcgatagcct 2276761 ctcacagtta agtagaccgc ttctgggtcc ttctcgccgg aatgacaata cgttttttcc 2276821 atttctgtct cccctcaccc tttattggct ttatttcatc ttatcattgc tttattgagg 2276881 taattttaaa gaaatgtaaa gattatatga atccgatata tagtaaaatg agagaaaaaa 2276941 agggagagag tcacattaag accgaaaaca ccttgagctt agatgcagcc agaggtgaac 2277001 ttgtaaatga aaaaacactt gtcaagagaa caatctactg gaattacccg gacagccgcc 2277061 cagcagtgac gtggatcaat cacaatacag tgaaaatcgg caatcagact ttacatcttg 2277121 atactgatga aacgtatgat tggcgaaaag atgatcattg gatccgtgaa gaaccgccgc 2277181 aggcgtcagt gaggtgatga aacatgaata agatgaacgg aacaaatgat gaaaagcatt 2277241 tcaatcattt tgtgattgct ttatccttta tatacggttt gactgaacta ggctatttgt 2277301 tgctgaagga ttttataaca attgccataa gtttgcctct gtagaaaaac gcagcgtagt 2277361 cgatacgccg cgttttttct ttttcccttc ctcttcttat tgataattac aggtcatata 2277421 atgtgacaaa tcgattgtag aaatagttcg attagaccaa aatccttttt atacatgtat 2277481 tcgaatttga agtgaggggg aagcttgatg gcagattttg ttgctagttt gaatgcggtc 2277541 ttatggagta cgcccgtcat ttatatttta ttgggaattg gattcgcctt ttcaattatg 2277601 acccgttttt tacaagtccg acatttaaaa gaaatgattg ttcagatgtt caaaggcaag 2277661 agctctgaag ccggcgtttc atctttccaa gcgttatcga ttgcgctgtc cggccgtgtg 2277721 ggcacaggaa acatcgcggg agtggcgaca gcaattgcat tcggcggacc cggtgcagtg 2277781 ttctggatgt gggcgattgc ctttatcggg gcggcgagtg cctttgtaga atcaacgctt 2277841 gctcaaattt acaaagtgaa acaagacggt caatatcggg gcggccctgc ttattatata 2277901 gaaaaaggct taggcattaa gtggtttgcc gtcttatttg ccgctgctgc ccttattgca 2277961 atggcctttc taatgccggg cgtacagtcc aactccattg cggctgggat ccaaaatgca 2278021 ttcggcatct ctcctttcgt cacagggtgc ggtctggttt tattattagg gttcattatt 2278081 tttggcggcg tcaaacgaat tgccaatgcg gcgcaaatga ttgttccatt tatggccatt 2278141 ggatatatcc tgctgtcttt gattattatt gtcatgaatg tgtctgaatt gcctgctgtg 2278201 atctcattaa tattcaaaag cgccttcgca ttggattccg cttttggcgg cttgatcggt 2278261 atggcgattt cctggggcgt taaacgtggc atttactcaa acgaagccgg ccagggaaca 2278321 ggcccgcatc cggcagctgc tgcagaggtt tctcatccgg tcaagcaggg actggttcag 2278381 gcattttctg tttatattga caccttgttt gtatgttccg ctacagcttt catgatcttg 2278441 tttaccggca tgtacaatac ccaggctgca gatggttcct ttatcgttca ccagcttaaa 2278501 ggcgtagaag caggacctgg tttcacacaa gcggcaattg acagtgttct tcccggattc 2278561 ggtgcaggct ttgttgccat cgctttattc ttcttcgctt ttacaacaat tatggcgtat 2278621 tactacatcg cagaaacaaa tatcgcctat ttagcacgag gcagagaaag caaatgggcg 2278681 atgcttggct taaaactgat tattttagcc gccacgttct atggtactgt gaaaacagct 2278741 tcacttgctt gggcattagg ggatgcaggg cttggcatta tggtatggct gaacgtcatt 2278801 gccattgtgc tgcttgccaa gccggcgctc cttgctttaa aggattatga gcgccaaaag 2278861 aagcagggct tagacccgat ctttgatcca aaagcgctgg gtatcaaaaa cgctgatttc 2278921 tgggagaaag aatacactca tgaaagtgaa cgtgtctcct gaacatacta aaaccggccc 2278981 gatatgacct cgtgccggtt ttttatgaac gatagtttgt atacacttct tgaacatcat 2279041 cgtcatcttc aaggacgtct attaatgttt ccagcttctc aacagcctga tcatcggctt 2279101 ctgcataggt attgggaagc atggtcacct ccgccgaaga aattagatat ttcgattcga 2279161 gggctgtttt cacctcttca aaatgctcag gctctgtgaa aacctcatat aggtcttctt 2279221 caattcgcag ctcttctcct cctgcttcaa gcacatcaag catgagctca tcttcttcta 2279281 tttgccgttc agtacggtct atcgtaatga acccctttcg ttcaaataaa aaggctacac 2279341 atccgctttc tcccagactt ccgccatttt tattaaaggc tgtccgcaca tttgacgccg 2279401 ttcggttttt attatctgtt acgcattcaa ccatgacggc aatccctgaa gggccgtagc 2279461 cttcataggt gatttcttca tagctgcttc cgtcttggcc tcccgcagct tttttaatgg 2279521 cccgatctat attttcattc ggcatattgg cgccttttgc tttttcgatg acaagacgca 2279581 atgctgaatt tgcttctgga tccgctccgc cttctttcgc tgccacatag atttcttttg 2279641 ccagcttcat aaatattttc ccgcgctttg catcctgtgc attttttctt ttttgaatgt 2279701 ttttccactt ggaatggcct gccatgtttt caccttcttt tacattttct atgtacactt 2279761 taatgggaaa tgttcgctga tgcaaagaaa aaggctgccg aatatcactt ccggcagccc 2279821 ttccttccta gcggttgttc attttatgaa gttttctgaa cagcccttta tctgttgata 2279881 cttggacgtc acggccattt gcatagttgc gcgctgcttt tacaacatta tctctgtcag 2279941 actttgtgaa ctctctgtgg cttttgactg cgataactac tcggtcatcc gataccataa 2280001 cttgtgtgtc attgacgttt ttcacttgtt tcacacggtt ggcaattttt gcagccagtc 2280061 ttctgttttc ttggttgtca tacccgttgt tcgctgcatt ccgattcatg tttcggttat 2280121 tcgtgttgtt atatgttccg tcagttgcca aaggaacacg atcgtcagca gtaacacggt 2280181 cacggttatt tacattcgtg gtgtttcggt taccgtcgtt ctgatcctcc attaattcag 2280241 aaacaggacc atcgtggtcg attccgtctc cctgtctatc ggcgtcattt tcatttgtat 2280301 aatatccgat tggacgggta ttgccgttat tgcgcgtatc attcatagca ttatcgtttg 2280361 ctccgcatgc tgttaagccg gctgtcatta gaatcaggct agcgatcgtc atttttttac 2280421 ccaatggaaa aaccccccgt ggacgaattg agcatgtttg ctcgctttta tcatgtgcgt 2280481 atggggggca tgttaagcgt gtcagttctc tccatttggc agtgatctgc ttgaaaacaa 2280541 aaaaaggaac gatttacatc gttccgaacg atcactcatt ttcttcttcc ggacggccaa 2280601 acatttggtt tacagaaggc tggttcgtca ttggcataga aactcctgcc gaatatgggt 2280661 ttggatttgg gttagctgtg ccatatggca tattagggct tccataagct cccattcccg 2280721 aatggccagg tgcagagaaa tatggctgat gatcaccgtc acagccgcag tcgtcatgat 2280781 ctttgtatgg catgtaacca tgagccgcag caggctggta tgctcccatt acttggggag 2280841 tgccgtaata agggccatac ggcatatgtc catacggaga tccataagcc ggagatgcgt 2280901 attgcggcgc accgtatgaa ccgtaatgtc cgtgatggct gttttcatga tgctggtttt 2280961 cataacccgg gtcatactga ggcgatacaa agcctggctg gtatccatgc atcggatgca 2281021 ttggataagc ttgtgccgga tagtacggat agcataatcc tgatcctgga agaattggcg 2281081 aaacaggcac cggacacggt acgaaatgag ccggataatg ataataaggc tgaacagccg 2281141 gcatcggcat attcggaact gtgtgatgaa cgttttcctc ttctataccg cctacctctg 2281201 gcgcctttgg catattaggc atattcggat aatttgcatt ttccatatta ctcatagcct 2281261 cctgttgtgg aaattggtct tgcatatgat acatatgatc catatttccg tcatgatgtt 2281321 ttttcggctc ctccggttta ggaggcgacc aaggctggaa aagctgtttc atatcataat 2281381 aatcgttcac atcagcttca gggtacacat tttcctgcaa attaggcatc ggcgggacat 2281441 acggcatgga cttcttttct ttcggctttg tgtcttctac atcgacaacg gatttaggct 2281501 tctctttcgc atatggatgt tcttgcttca cactcccggc cgcaggactt ttgcccgctt 2281561 ttggctcttt tctgaccggg actccttctg acggcacttt tattttcatt ccaggcatga 2281621 ttaagtctgg attgctaagc tgtgtattga gttttttcac ttcctcaaca tcgactccgt 2281681 acttttcagc tattttccag agcgaatcgc ctttttgaac gatatggatt ttcaacgttt 2281741 tcccctccta tgcaaaacgt gaacagttca gctgtgatta caatatgttt cttcacaaca 2281801 tatgcctgaa caaaagaagt tatgagtaaa ggaagggaaa atatttctga tctacgtgat 2281861 cgaaagcatt cgattcaggg caaggagtgc atcttcctga atggcttttg gcaccttgat 2281921 gacgcctgaa ggttctcctt tttcaatttg ttccagcgac cacaacaaat gcggcaaatc 2281981 aattcggttc attgtcaggc aagggcacat gtcagggttg agtgattcga tttgtttatc 2282041 tggatgctcg tgaatgatcc gctgaacaag attcatttct gtcccgattg cccacttgct 2282101 tcccgccgga gcctggttga ttgtgtcgat aatatatttc gttgatccgt tatcatcgct 2282161 tagtgtcacg acttcgtgtg aacattccgg gtgcacaatg atctgaatgt cggggtctcg 2282221 ctctctcata tcatggatat ttttagtggt gaatttctcg tgaacagagc aatgcccttt 2282281 ccacaaaatc actttcacat tcgtatgccc ggattcagct actaattcat ctttcatcgg 2282341 atcccacaca gccatatctt caagcgcaat gcccagatca taagccgtat ttctccctaa 2282401 atgctgatca ggcaaaaata aaattctttt tttctgtgta aacgcccatt caagcacttt 2282461 tttcgcattc gaagaagtta cagttgctcc gccatgcttt ccgacgaatg ccttgatctc 2282521 cgcagtggag ttcacataag ttaaaggtat gatcgtatct ccaaatatat gctgaagctt 2282581 cttccatgcc ctattggtct gctgcatgtc agccatgtca gccatagaac atccagctct 2282641 catatctggc aggacgaccg tttgctgctc gcttgtcagc atatcggcgg tttctgccat 2282701 aaagtgaacg ccgcaaaata cgatataatc cgcttctttg tttttttccg ctacttgggc 2282761 caattgcagg gagtcgcctg tttggtcagc aaattgtatc acttcatcct tttgataatg 2282821 atggcctggt ataaagagcc tgctgccgaa ctttttctta atggcggcaa cgcgcgtttc 2282881 catatccttt ctcgatagtt ctttataact ttcgggcatc atatcattcg attgtttgat 2282941 cacatcaaga attgacataa cagcattcct ccacagattc atttgataac gtaacatcca 2283001 tgctgatatc taaacttttg acggaatgag tcagaaatcc taatgaaata taattcacac 2283061 ccgtcccttt aaaagcaggc aaagattcta acgtaatccc gccagaggct tcagttttta 2283121 tattagccgg tgtgagcttt gcaaaatgac ggaccgtatc aggcggacag ttgtcaaaca 2283181 taataacatc cgctccagct gcaattgctt cccgcagctg ttcctccgtt tcaatttcca 2283241 cctcgatatt taccatgtgc cctgcggcct gacgggcttt tttgcacgcc tctaaaatag 2283301 agccgcatgc tgcgatatga ttatctttaa tcatgatgcc gtcatacaaa ccgaatcgat 2283361 gattataccc gccgccggct ctgacagcat atttctccag cattctgagc cccggtgttg 2283421 tttttctcgt gtcacaaatt ttaatctgtt catcatccag acaccgaaca gcctctcttg 2283481 tcattgtcgc aattcctgac agcctctgaa taagatttaa tacgacccgc tctcctgaaa 2283541 ggagcgcagc tgcgggaccg tgtaactcgg caatcacttc acctttatgc aacatgtccc 2283601 catctttttt gtgtaaaatg ctttgaacat tttcgtccaa taacgaaaag ccttctttta 2283661 tgatcgctgc tcctgcaaaa ataccctctg actttgcaac aatctccgct tcacagctct 2283721 gttctccaaa aatagactgc gatgtaagat cccctgtccc aatatcctca agaaaaaagt 2283781 gattcagtaa ttttttcagc tgtaaatgat tcattgttcc aaatcccctc gttttttctg 2283841 atcttcgttc ctttttttgt atggacaatt tgtcttcctt gccagctcac ctcagcatga 2283901 ggaaaatcgg tgcggaagtg agcccctctg ctttcctccc gcaaaagcgc agaaaacgtc 2283961 atcagctttg cagtttgcca tagatgagaa agttccatct gccgaattgt gatatccttc 2284021 acatttactt cctgaaaagg cagcgtatga agccagatgc taagctcaat caaactgctt 2284081 tgttcccgca gaatagacat gtggcttgtc attttgcttt gcagttcatg cccctctata 2284141 tccggcacct cgtagaagac actggtttct agccctgatt gatattgcct gttataaacc 2284201 ggtttttgga taatatgctc tgctgccctt tttccaaata ccagcgcttc caataaagaa 2284261 ttgcttgcaa gccggtttgc tccatgtaaa ccggagcatg ctgtctcgcc aatcgcataa 2284321 agccccggca ctgtcgtttc tccccagcga ttaactgaaa cacctcccat taagaaatgc 2284381 attcccggag caacaggaat ttttccgctg tggatatcaa tccctgcttt ttcacaaata 2284441 gcggtgatgg tagggaaacg cgtttcaaaa tcagaaatcg cactgaagtc tatataaacg 2284501 cgatttcctt ttgccatttc ttcgtgaata acccgtgaga caatatctct tggagccagg 2284561 tcacctaaag gatgccgttc agccataatc ctgcggccgt tttcgtctac taaacatccg 2284621 ccttcccctc tgacagcttc tgaaacaagc ccgtaggaaa caccattttt cacaagcagt 2284681 gtcgggtgaa actgagtaaa ctccaaatcc gttaattccg ccccggcccg gtaagccaga 2284741 gaaagaccgt cacctgtgac agtgagatca ttcgtatggt gaagaaacag gtttccacag 2284801 ccgccggcag ccagcacaac ttcgtctgcg tgccttacct tgagccgccc tttgctgtct 2284861 tttgtcatga cgccgataca tcgtccgtcc tctataagca aatctgctgc cgtttcattc 2284921 tcgattaact tgattttgct gttgatccgt ttgagcaaat aatcgataag cagcctgcct 2284981 gttgcgtctc cgcctgcatg aaatatgcgg ttgtatgagt gggccccttc tcttccaaga 2285041 caaacaccgc ctcgttcatt gcggtcgaat ggaaatccac gctccaatag gctttgaacc 2285101 atcatttttc catcatgtaa tacgtctgct acaatagcta gattattatg gccgcaccct 2285161 gcgtataacg tatcctccag atgggcttca atcgagtcat cttttgcata ggccgcagca 2285221 atcccgcctt gtgcatagac agaattgctg tttttgacgc ttttttttgt gataacagtc 2285281 acttcgtatg agggcgggaa agctgcagct aaggaaagtg ccgccgcccc tgaaccgatg 2285341 actgcaatcg tctttttaga catatgccat cctcctgttg tttacacctg tcttgacacc 2285401 tatatttaca caaggataaa ataaactcaa gagtttttta tggagaacgg atggaggaag 2285461 accggatgat ttatttagat tatgcagcga caacgcctat ttgtgaggaa gcccttactg 2285521 tatatcagaa gcttagtatg gatatgtacg gaaatgccag cagcctgcat gatgcaggag 2285581 gaaaagcaaa gcacatactg gagtactgcc gtgaaaaaat cgccaacatc attggcggag 2285641 aagcaagcgg catctatttt acaagcggcg gcactgaatc caattttctg gccattcaat 2285701 cattgttaaa cggcctgcca aaaacgaaaa gacattttat tacgactgcc atggagcatc 2285761 agtccattca taattgcgct gcttttttgg aacagcaggg atatgatgta acagtcattg 2285821 aaccgaatga atacgggctt attaccgagg aaatattact aacccatatc cggccggaaa 2285881 caggccttgt atctattcag catgcaaatt ctgaaaccgg gatcattcag cccattcaac 2285941 acctgtcttc atacctgcac aataagggga ttcttcttca ttgcgacgct gttcaaacgt 2286001 ttggaaagat cccgatcaat acaaaaaatc tgggagtaga tgcactctca atgtccagcc 2286061 ataaaatcca cggtcctaaa ggagtagggg cggtctatat ccggccggat gtcccttgga 2286121 aacccgttta tcctctgact actcacgaat acggattcag agccggcacc gtaaatgttc 2286181 ccgggatcgg tgccttcact gccgctgcag aattgatcgt aagcgaaatg gaaaaacaga 2286241 tatcccgcaa tgaggcatta agaacatact ttctagacca aatccgtatt cggtctctcc 2286301 ctgtaaccct tgcagcagac acttcgaaag cagaatgtct tccgcatatt atagggtgtt 2286361 tttttcactc atttgaagga caatatgtta tgttagaatg taatcggagt aatatttgca 2286421 tttcaaccgg cagcgcttgt tctgcaggtt accacggtcc gtctgaaaca atgaaagcat 2286481 taagaaaaac cgaacaagaa gctctgcaat ttatccgcat ctcttttggc aggcatacaa 2286541 cagctgaaca gctggaacag ttattacata cgtttacagt gctttgggaa caaaagaaag 2286601 gagaatttga tattgaccga agaattaaag ctaatgggcg ccaacaggcg tgaccagctt 2286661 cttctgtggc tgaaggaatc taaatcaccg ctgacaggag gagaactcgc aaaaaaagcg 2286721 aacgtctcaa gacaggttat tgtacaggat atatcgctct tgaaagcgaa aaatgtaccg 2286781 attatcgcca caagccaagg atatgtatac atggatgcag ccgctcagca gcaccagcag 2286841 gcagaaagaa tcatagcatg tctgcacggt cctgaacgga cagaagagga actgcagctc 2286901 atcgtcgacg aaggcgttac agtaaaagac gtaaaaatcg agcatcccgt atacggagat 2286961 ttaactgcag ccatccaagt aggcacccgg aaagaagtta gccatttcat caaaaaaatc 2287021 aattctacga atgctgccta cttatcacag ctgaccgacg gcgtgcacct gcatacactg 2287081 acagcacctg atgaacatcg catcgatcaa gcctgccaag ccctcgaaga agccggcatt 2287141 ttaattaaag actaaaaaaa gccctctagt gggctttttt tataattggt aagactggta 2287201 tgcacccaga agcctcactt tgcagccgag tgcttcaagc tcctgcatgg cccctggaat 2287261 caatacatca tcaaacgctt tctcaatatc aataataaag aaataatggc ctaatccggt 2287321 tttagtcgga cgtgactcaa tttttgacag gtttaaattt ctccaagaaa atgcagacag 2287381 cactctatgc agcgccccgg actgatcatc ctgcggcagc atgaccatta aggtcgtttt 2287441 gggcctagag ctcaattttg aattcacttc aaaagatatg ttttcatcgg gagacaggat 2287501 aacaaatctt gtatgattgt ccctataatc ctgtatatcc cgtttcacga tttttaattc 2287561 gtatgtagaa gctgccatat cattggcaat gaccccgata ttcagctcgg gatggtcact 2287621 gacaaacttt gctgccgccc cggtagaatt ggcgtattca tatggaacgg aaggaaaatg 2287681 tcgatgaaga aatttatggc attgcgcaat cgcgtgtgaa tgtgagtaaa ttttgtcgag 2287741 ctctttccat gcattctctc ttgagggatg gacgagcaag tgctggtgaa tcggcaacgt 2287801 catttcaccc acgattggca aaggctgttc atgtattaaa tagtctattg ttagattaac 2287861 agatccttct aaagcatttt ccaaaggaac aaaagcaaaa tcaacttcgc ctgcaacggc 2287921 tgcatctata cactccggaa tggtgcggta agcaacatgt tcggcgccgt tttgaaaaca 2287981 agaactgact gctagatgtg taaatgtagc tgctggacct aaataaccga ctttcatgac 2288041 gattttctct cccttatgca cctgaaccta atatttcaac cttttctaca aaatcaaact 2288101 tcctgagctt attcattaat gtatgaatgt cttcttccat tgccgacgta ctgatagaca 2288161 gtgtcacatt tgctctgcct tgaagcggaa tggtctggtg aatggaaaga acgttgcttc 2288221 cagaatcagc taccgcctga agaagctgag ataacgcacc tgacctatcc tccaaatgaa 2288281 agaaaagtgt gataatttgt tcttttacca tggtgtagaa tggaaaaaca gcatccctgt 2288341 atttataaaa cgcacttcta cttaaatcga ccttttgaac ggcatctgct actgaatctg 2288401 ctttttttcg atcaagcagc tttttgactt ctaatgtttt tctcattgca tcgggcaata 2288461 catcttcacg gacaagataa aatgtctcct ctttcatttg catcccccct ttaaaataga 2288521 gagcctggca ccaggctctc ttttcagcca acattgatta atcaataaat tcaaattcaa 2288581 attccagaag cctgattata tctccatcct tggctccgcg ttctctgagt gcttcatcaa 2288641 cacccattcc gcgcatctgt cttgcaaacc gtttaaccga ttcatcacgt gagaaatcag 2288701 tcatcttgaa taaccgctca aggctgtctc ctgaaagcac aaatacaccg tctggatcgc 2288761 gtgtaatgtt aaatggcact tcttcatttt ccatcgtgta catgacacgg ttttgtgtaa 2288821 gctcttcctc gtcatacagc gggaattccg gtgtgttctc aagctgattg gcaacctcaa 2288881 acagaagctc acgcagacct tctcttgtca ccgcactgat cgggaatacc ggataatcat 2288941 ccgtcagctt ttctttaaag gcttcgagat tttccgcagc ctccggcatg tccattttat 2289001 ttgcaacgat aatttgcgga cgctcagtga gacgcagatt gtactcgctc agctcctggt 2289061 taatcgtaag ataatcatca tatggatcac ggccttctaa gcctgacatg tcaatgacat 2289121 gaacaataac cctcgtccgt tcaatatggc gcaaaaactg gtggcccagt ccgacgcctt 2289181 ggtgtgcgcc ttcaatcagc cctggcaaat cagccatgac aaagctgcgt ccgtcatccg 2289241 tttcaaccat gccgagattc gggacaagcg ttgtaaagtg atagtccgca attttcggtt 2289301 ttgcagatga gacaacagac agcaaagtag attttcccac actcgggaac ccgacaagtc 2289361 cgacatctgc aagcactttt aattcaagaa caatgtagcg ttcttttccc ggctcgccgt 2289421 tttctgaaag ctgaggcgcg ggattagccg gtgtagcaaa gcggctattt cctcttccgc 2289481 ctcttccgcc tcttgcaatg acagcccgct gtccgtgctc tgttaaatca gcgatgacct 2289541 gttttgtatc atcgtctgtc acaacggtgc ccggcggaac tttaatgacc atatcatcag 2289601 catttcgccc gtgctggttt ttggacatgc catgctcgcc gcgaatcgct ttaaagtgtt 2289661 ttttgtatct aaaatccatc agggtgcgga gaccttcatc tacttcaaaa acgacgtctc 2289721 ctccctttcc tccgtcaccg ccggcagggc cgcctttcgg cacatatttt tcacggcgaa 2289781 acgcaaccat accgttgccg ccgtcgccgc cttttacata tactttgacc tgatctacaa 2289841 acataatgtc ctccgttcta aaccgttaaa aactccgcta gtccaaccca atttcaatca 2289901 gacattcgtg actcgtgatt tcaaaacgca tgatatcaac gtcctcatat ccattctgcc 2289961 gaatatcatc aaaagcagat ggatcggcaa aggcgccgtg aaaatcaagg tacagaatca 2290021 gctgtctgtc aggatgatcc gtttgaagcg aaaccgttaa atgattttca ctctctctgc 2290081 tgactgcttg atcaaacaga tgaaacagct ttctcatcag tttcgccagc ttttgatcat 2290141 aagccgacaa atccttaatt tctccgagaa cttcatattc aagcgtcata taatgggttt 2290201 tccaattaaa cgtaagaaaa tcaaacgcca aatgcggtgt tttcaggttt gagagctttg 2290261 attcgtgctt tgcgtctata accatttctt caatcatttc aaagacacgg tcatacttct 2290321 gtaagcttaa gtttccttta atcagctgca gcttattcat ccaatcatgc cgggaatggc 2290381 caagcagatg aatcagttcg tttgttaatg ccgtgtcgct tatattttct tcttgatttt 2290441 ttgaaacatc cttcattttc gcactcccaa tcatttaatt tcttatttag gagtctgtat 2290501 aagtgtgtat tatgaattat aacagagaag gctttgttag aaaaacaatt gtttttccca 2290561 gaaatatcat gttccttttt tctggctttg gttgatttgc agccaggcag aacattttat 2290621 gtattactgc ttggggaaca tatccagtgg gtttgagatg tttattctca ttcttggcgg 2290681 ggtctgctcg cacatactct gcatttcatt ctaggtgttt actccgcata ttgcaaaaaa 2290741 aactccagtc atcatcgacc ggagtttttt gaatcattat tgagctacag gatatacgct 2290801 cacttttttg cggtcacggc cgaaacgttc gaatttaaca gttccgtcga ttttcgcaaa 2290861 tagagtgtca tctccgccgc ggcccacgtt ttcacctggg taaatttttg ttccgcgttg 2290921 acggtaaagg atagaaccgc ctgttacgaa ttgaccgtca gcacgtttag cacctaaacg 2290981 tttagcctca gagtcacgtc cgttctttgt agaacctact ccttttttag aagcgaaaaa 2291041 ctgaagatct aatctaagca tgtagctcac ctcctatatt atgtttgtgg tcacacgcaa 2291101 gttgtctttg taatcccgtt cgattgtctc cagcgaaaca atcatgcctt caatcagcag 2291161 ctgagctttt tggcgtgcct ctggatcaag agattcaggg aattcaaaat aaaaataacc 2291221 cccgtcctct cctatatcaa gaagcggctc gaagcccgcg agcacaatga ccgcgttaac 2291281 ggccccaaac acaacggctg tcactccggc acaaacaaga tcttgtccat gttcagcaaa 2291341 attcgcatgg cccgtcattt caaaagacaa tatgccttta tcatgagacc ttctgattgt 2291401 tgcctgaatc atgcttacgc gttgattttt tcgatcgtca ctttagtgta aggctgacga 2291461 tgaccttgtt ttttatgaac gtttttcttt ggtttgtatc tgaaaacagt gatttttttc 2291521 gcgcggcctt gtttttcaac tttagccgtt actgttgcgc cttcaactgt agggttgccg 2291581 actttcacgt tgtctccgcc aacaaacaaa acgtcttcaa aagtaactgt ttcacctgct 2291641 tcagcagcaa gtttttcgat gtaaacagtt tggccttctt caactttgat ttgtttaccg 2291701 cctgttttaa tgattgcgta cattctctgc acctcctatt agactaagac tcgccagata 2291761 ccagggggct gtaaaagctc ttaacacctg tactgagcgg ttgtagcaat ggtgctacat 2291821 ccataacatt aaaaaatata ccaaaataca aggcgtttgt caatcagttt tagtagggca 2291881 gaagcagttc ctccatggaa gaattcgtcc gcttatcggc aaagtaagcg tgcagcactt 2291941 cattctcgtc aagctggctg agcttttggc ctgatttttc tataataatc ggatgcttac 2292001 agccacgttt gaactcggcc atcacatgat agactttatc ctccgccttt actgtcagcg 2292061 gcagaagttt ctcaagctcc ctgttttttc cgtaatacct ttcgaggaga aatctcacat 2292121 ggatatagtg cctttgccga tattcctcaa acaaggaaac agccagaaag acaaacaaaa 2292181 cccatgcgct gatttgcaga ggaatcacga ataaaaccca gcacccgagc agcaggcaga 2292241 agcagagcga cgtttttaga ttaagccggt gagccttttg aaaaggcagc tgtttggaaa 2292301 acaacaaaaa taacagtttt cctccatcca gcggccagat cggcagtaaa ttgacaaata 2292361 agatagaaag attataaaag gtgaagagtt caaaggtatg ctgatgaatc actgagactt 2292421 ctgcaagcat ccaggcggca aactgaagcc agatgtgctg aagaggtccg gcaataatga 2292481 ccgcaaactc ttcctttaac ggccgattcc cgtgctcttc cacttcgacc gttccgccaa 2292541 acggcagcaa aaaaacacgc ttgattctcc aagaaaaaaa cacagccaga gcagcatgcc 2292601 ccagctcatg aatcaataca atcaggagca gacataataa tgctttcata tggcctgtga 2292661 gcaagcccag cgccgcaata atccaaagaa aaggatgcac atggatcttt aagataaggt 2292721 cgagccattt attcaaatga aatcacctga atcggatcaa taaatttatc gccgtctttc 2292781 atggcaaaat aatagacccc tttattatga tcatcaagct taatcgaacc gagctttttg 2292841 cctttatcca caaaatcata taaagcaaca tccacatctt tgagctcgcc atagatacta 2292901 taggtgttgt cagcatgctg caccttaacc gtcagtcccg tttggctgtc tttgctgact 2292961 tcaaccacat agccttcttt tacgctatca atcttatcac tgcttgtttc gactttaatt 2293021 ccttccccat tgtcctgaaa atcctgctgt actttcccgg atgcaggcgc gatcagatct 2293081 ttgcctactt caatctgctg ttccttattt ttgtgttcag gagccaggaa agcaagcgga 2293141 tttccgaatt tggtttcgaa ccaatggctt gctgaagcaa attgaaattc agtttcaaag 2293201 gttttggcta cggcgggttt aatctgactg acgggtccaa tgtttgtttt ataggctata 2293261 gctgaaacga gaacaaggca ggccgacaga agacatttca ggataattga atctgttttc 2293321 accaatgggt gttttccgtt gaatgttggc atgttatctt cgtagaccgg aagtgttcca 2293381 tgcttttcct gatccgttac catcacccag gacgggggtt tctgcttttc agaaactgtc 2293441 tgagtagaga aacgttttga gccggaaagc tgctttcttc ttttctctaa tcgttttctg 2293501 atttcatctg ctctgtgact cattgccatc atcctttgca ttcgttgggt ttgtacatca 2293561 tatgtcttgt ccatggcaaa tattcggttt agtcaagaac aaagcaggca aaaacaaaaa 2293621 aaacctgaca cagcatatgc tttgtcagat tcttctcttt gattctatca cattaagatc 2293681 ttactccgaa aaatgactta atcttagcca tcattccttt gttttgctct tcaagcacct 2293741 gtaaaggaac agattcacct aagatgcggc gggcaatatt gcgatatgca atggaagcgc 2293801 ggtttttagg gtccatcgca atcggttcgc catgattgga agctttaatg acttcatcat 2293861 catcagccac gattccgagc aaatcgatcg acagatgctg tacgatttcg tcgatatcca 2293921 tcgtgtcacc gtttttcatc aggtgatttc tgattctgtt aacaacgagc cgcggcggtt 2293981 caatattttc ctcttgctcc agcagtccta taatacggtc agcatcacga acagctgaga 2294041 tttcaggcgt agtgaccaca atcgctttat cagctccgga aacggcattt ttgtaccctt 2294101 gctcgattcc ggcaggacag tctatgatga catagtcaaa ttcctgtttg agctcttgga 2294161 ccatgttttt aatttgttca ggagcaacag ctgtcttatc gctcgtttga gcagcgggca 2294221 ttaaatagag cagatcatcg aaacgtttgt cttttacgag cgcctgatgc attttgcatc 2294281 tgccctctac aacgtctacc agatcgtaaa taattctatt ttcaagaccc attacaacat 2294341 caaggttgcg cagtcctata tcagtatcta ctaagcatac gcgcttccct aaaatggcta 2294401 aggcggtacc gaggttcgca gatgttgttg tcttacctac tccgcctttt cccgaagtta 2294461 ttacgatagc ctcacccaat tcacattcct ccctcaagcc ttgttagatc aggtcttaaa 2294521 tgagccaaat gttgaaggcg ttcaatgacc atatttccgt ctgtatctaa ataagcacat 2294581 tccatttcgt tccctttttg aatgtggtct ggggagcgat ttaacacatg attgattctt 2294641 aattgtgtcg gaagcatttc agaggcggcg atgaccgctt gattatttcc attgaatcca 2294701 gcatgcgcaa ttcctttcag tgagcccaga acaaaaatgt tccctccggc cctgactgtt 2294761 ccgccgggat tcacgtcacc gatcaggagc aagtcgcctt ttacctgcag cacttggcct 2294821 gaacggacaa tttttgaaac agaaataatt tcggcttcct ctcttatctg ctgtgcttct 2294881 tttttagtaa tgacttcact gtcaatagaa tgaacaaaca aatctttctt tgacgcaatc 2294941 aattcggtta gctgttcctc ttgctcctta tataaaaagc gatttcccag cttaacatga 2295001 acgctgattt tctggccttt tccatcggta tattgttcaa ttgacagcat attctgaaga 2295061 ccatcgagaa gctcatcaaa agaacacgca tcatccagat gcaatgttag tccattcttt 2295121 gttcctttta ttgttacata ttgctgcttt ttggtcttca caatattcac ctcaacaaca 2295181 tactcatttc gtcaaaaaaa gataaaatcc tttttactca tctctcaatt ctttctttag 2295241 actcataaaa aacaatctaa atggcagaac aagaataaga gctgctgcaa tatttaataa 2295301 aattgtcggt ataaaccggt caagcacaaa tccgttaaac gtcataatgt ctttatgaat 2295361 caaagactga atgccgaata cgtaaaattc gagcagacag acagccagaa ctgctatcaa 2295421 tatcactaca aatgcgtttg tatgcaacac tttaaacgct tttgaagcca aatagcatag 2295481 ccctgcaaaa ccaaacatgt aaacgcctaa tagacttgta tagttcatgt catatagaaa 2295541 gccaaaaata aatccgtaaa tcatcgcgtg tttttggttg ataaaagccg acatgaatat 2295601 caatacaagc atcaaaaaac gcggggcgag cacttggtca tctgtaacga aaggaaaatg 2295661 caccaaatct gtaaaaatgc tttccgcaga aaaaacaagc atcataacga aagggagaag 2295721 gaaacgtttc acgatccttc ctcctctgta tcgacagtcg gcacgtcacg gttaacaacg 2295781 atcacattat ttaaatctgt aaggtcagcc gcaggtttta cataagcaac cttcgttaat 2295841 ccataggaat ctgactcgat atcagtcact tcaccgattg tcagcccttc tgggaaaaca 2295901 ccgcctgtcc ctgatgtttc aataagatcg ccttttttca cgtcttgttt atccttacgc 2295961 tcaataattg tcatcttaag acgttttttc tctttgtcat atccttcgat caagccgtag 2296021 cctttgctgc ctttttttcc ggaaattttt gtcgcgactc tgttattgcg gtcagtatcg 2296081 cttaaaagct gaacagcaga cgtaaaattg ttaagtccgg agcttttgat cttgccgatt 2296141 aatgcgcctt tttcgtttgt aacggccata tctttcgcta cgttttgctg agtccccttg 2296201 ttaatggtga cctgtttcgc ccaattatca gggcttctgg cgatgaccgt tgctaaaatc 2296261 ggcttgtaat ctttaatcga tttgacatgg ccaagctcgt cacgcaagga tttgttttct 2296321 tcttcaagct cttgaagctt ggcttcatat tgtgtctgtc cgtcaagttt ttctcttaga 2296381 cgctcgtttt ctttgtatgt gttttttaaa tcattgatgt tctcaaatat tcctgcaaaa 2296441 aattcggcag gcgtatgaaa aatattttga aatactcccg tcgtatcgcc gatcactttc 2296501 tcaggccagg tggtattgcg gccgcccttc agcgaaaatc caatcatagc caccaatatg 2296561 ataatacaca gaagtaatag cattaaccgc ttattcggca tcgtgttaca cctcttctat 2296621 tgaactcccg attatctagt tttccctttg aaaagatgga tgtgctccag tgctttccct 2296681 gttccgatcg ctacacaatc aagcggatct tcggcgataa ggaccggcat ttttgtttct 2296741 tcgctgatga ctttgtccaa attgcgcaaa agcgctccgc cgccggttaa cactatacct 2296801 ctgtccatga tatctgctgc aagctcaggc ggtgtttttt cgagtgtgct cttcactgct 2296861 tcgacaattg tagatacagt gtcgcgtaga gcgttagaaa tctcttttcc tgtaatttca 2296921 attgttttcg gcaaacctgt gagcaaatcg cggccgcgga tttccatgtt gtcggattct 2296981 tcaggagctt ctgcagatcc gatttccatt ttaatcgctt cagccgtacg gtcaccgatc 2297041 atcagattgt acgtttttct gatgtagttg ataatcgcgt catccatctc atcaccggct 2297101 acacggattg actgagacgt tacgatgcct ccgagggaaa taatcgcaac ttctgtcgta 2297161 ccgcccccga tatcaacaac catgcttcca gtcggttccc aaactggcag attggctccg 2297221 attgctgcgg caaaaggctc ttcaatcgga tacgcgtcac gcgctcccgc ctgtcttgtc 2297281 gcatcgataa cagcgcgttc ttcaacagct gtaatgcctg atgggacaca taccattaca 2297341 tatggttttc tggcaaacat gcctttattt tttatggcct gattgatgta atatttcatc 2297401 atcgtcgccg ttgtttcata atcagcgata acgccgtctt tcatcgggcg aagagccacc 2297461 acgttgcccg gtgtccgtcc aatcatattt ttcgcatcat ttccgacagc gacaatcgat 2297521 ttcgtatccg tctgcaaagc gacaactgac ggctctctca caacaattcc ttttcctttt 2297581 acaaaaacaa gcgtattcgc agttccaaga tctataccaa ggtctctagc accaattcca 2297641 aacatatgta tgtatcttcc tttcttaaag caaaaatacc ctaaagggaa aaactcataa 2297701 actctattat agcttaattc gacgaaaaaa aaagtgttac aaatatcctt tttcctttaa 2297761 actcacaaat tttttatccc cgatcaccaa atggtcaagc agctcgatgc caatcaggtt 2297821 tccgcattca aacagccgtc ttgtcacttc aatatcttcc ctgctcggcg tcggatctcc 2297881 agaaggatga ttatgaacac agataaagga agcggcagat cgtttaaacg cttctttaaa 2297941 cacctctcgc gggtggacaa tagatgaatt caggcttccg ataaatacgg tgcgtttatg 2298001 gatgacttga ttttttgtat ttaagtataa acagacaaaa tgctcctggg ttaaaaagcg 2298061 catatcctcc atgacaagat tagcgccgtc ttccggggag cgaataacga aatgttcttc 2298121 gttggctaat ttatgaatcc ggcttccaag ctcaactgct gccagtattt gaatcgcttt 2298181 taccataccg attcccggga tgcttgacag ctcttcaacc gatgcttcct tgagcaggcg 2298241 cagcccgtca aatgagcgca gcagccggtt tgacaggtcc aaaacagatt cgtgtttagt 2298301 ccctgtccgc aataatatag ccaaaagttc atgattcgct aagttctcgg ctccgacttt 2298361 caggagccgt tcccttggct tttctttcat tgggaaatct ttgagtttta atggcagatc 2298421 gtgtatgacc aagcactcct tttctttccc ttcccgttta tagaaccgtc atgcccttat 2298481 atcaaaatgg cgaagagctc tcattgtttt tgatatagga aggcccatga ctgaataata 2298541 atctccgtct attttcttta caaaaagcgc gcctcttcct tggatgccgt atgcacctgc 2298601 tttatccatc ggctcttttg tttcaatata tgtccaaatc tcttcttcac tgagggacca 2298661 aaacgcaact tctgtcttat cataaaaagt ctcgctgtga ttttcagctt gaatgctgac 2298721 cgcggttatt actgagtgac ttcggcctga aagcctccgc agcatagaag cagcttcttc 2298781 ttgatcctgc ggtttgccaa gacattcgcc gtcaaggcat accattgtat cagcaccgat 2298841 aacgattgca tgcgggtgga gatcagctac agccttagct ttttgttttg ccaaccattg 2298901 gacgttttct tctggtgaaa agtttcgatt taatttttct tctacttcac tgacaataat 2298961 ggagtagggc agctggagaa gatcgaggag ttctttcctg cgcggagatt gtgatgcaag 2299021 tattagcggt tttgtcatgt tcgtcatcct ttcagggttt gcttaagaaa aaaagatact 2299081 cgtttatcct accaaatcac gaggcttgtc acaatttcag aaaaataact ttttcatgac 2299141 aaaataaaaa aagcctgtca ctaaaggacg aaggctcagg gcactatctc ttattttacg 2299201 acggctaaca gctcctgctg agccttccac ccggcttcag cacttggatc ctctaattcc 2299261 tttaaagcct gcaaaatcgc ttttttctct cctgtttctg acgcttttgt ttcaccaagc 2299321 gacttttcta ttttctctac actcgctttt gtaatgtctt cgtcgagaat cgcctttgct 2299381 gcaagctccg ctgtttcctt aaaagaatct gtcatatctg actctattga taaggaaagc 2299441 tccttgcctc cccaggcttc aaaatcactg tcgattaaaa cctgtcctaa ctgctgtgag 2299501 acctcctttt cacttgctaa gcctgcaata acatacgtat acccgtcatc ctttgacagt 2299561 gacacggcgg aatatccttt ttcggtcaat tgttctgtta acgtttcggc gcccttttca 2299621 tttgaaaatt ttccggcttg cacagcgtat gttttgtatg taccttcagt ttgtgccgct 2299681 tgtttttctg cgcctgaggt ttgtttatca gcagaagtat cccctgcttt tgccgtttgg 2299741 ctgcctaaag aatcctctaa agaggccggt gctgacgctt ctttattccc cgatatgttt 2299801 aacgcgaata accctaatcc agtgccaatg acagccgcga aggcaatcgt cgcggccact 2299861 ctttttaccg gtttggcagc cccggtcttt ccttttgcgt aaagctttgt ttttttcttt 2299921 tgaaaaggag gaacaacttt agggtcctct ttaaacacct tgtcctcctc ggaatcccaa 2299981 ttgaattcat cttcatcagg gtgttcctgg gatgccgcaa cctcttgttc tgcctgtctt 2300041 ttttcctccc aatttgaaaa tgtcatgctt ttattcgcct ctgtctcagg cgtctcttgt 2300101 tcgtaaaccg tctcttcttt tccattaatc gtcaccttga gggctttttc tgcggcttta 2300161 ctgttttttt tattctttct ttttttcaat tccgcttcct cccttcattt gcttgaccgt 2300221 tcttgtcggc ttttcatgct acacacttta gcacaggcaa agaaaaaaag aacaagactt 2300281 ttgtcgcctt gtccaaaaaa cgttcgtcaa atttttcagc agtcagccca atgccatttt 2300341 gatataaaaa gaaatgatag agtcaccgta taaataggct aaaatgctcc ctgcggctat 2300401 agcgggggcg aagggaagcg gctgcctttt agcgagtcta ccagtcagaa cagctgccgc 2300461 tccatataat gcacctatca aaactgaaaa gaaaaaggca gctgccagca ttttcacacc 2300521 aagcacaaag ccaatcaccg caaataattt aatatctcct ccccctactc ccccatgggt 2300581 gattgcggca attacagcca gaaacaaaaa tccggctgcc gcacctaaca ggcctgcata 2300641 ccaggaatca agcggagaaa tcaatctcgc ggccgccaaa aagggaagaa agaaaatcaa 2300701 tattcgattt ggaatcagca taaaatgaat atctgtcact gcaacaataa tgagaagaga 2300761 gataaacacc acagcgggaa acagttccag cgatatgcca aagcgtattc ctgcggcggc 2300821 aaataaacac gctgtcacaa gctctgctgc gggatacata aaagaaatcc tatgcccgca 2300881 gcttttacat ttaccttttt gaaataggaa tgacaggatg ggaattaatt ctgcaggagt 2300941 taatgttcgc cggcaaaacg ggcatgatga acggggcgca ataatagata gatgtaaggg 2301001 gatacggcac ccggccgtat agtaaaaaga accaaggata agcccgaaga taaaaagaat 2301061 ggatagcata gacaacacac ctttactcat tgagttctgg tatggattgt agcaaaatgg 2301121 acatcctgag ctccaattgg gaatattcaa ttttacacat gaaaaaaacg gcagaatctt 2301181 tttttgattc tgccggagcc ggatgctttt atttcaacct ttttcgaatg tcagaaataa 2301241 agtaaagaga tccggtaatc agcacaattt catttgagcc ctttttactt tctatgaatt 2301301 tgattacatc gtctggatct tcactccagc ttttattgct gatttcactt gcatcataga 2301361 gatcttttgc aagggaagca cgcgggaaat caaaagaagc aaaatgaatc gcatgagcaa 2301421 tggtttccag tcttttaatc atgttctgat acggtttgtc ctttaacgcg ctaaacacca 2301481 cagaaatgcg tgaattggcg aaacgctgct tcatcgtttc cgccagcttt tcaacacctt 2301541 cttcgttatg cgcaccgtct aaatataccg gaggatgttc ctgaacaagc tctaaccgtc 2301601 ccggccaagc agccttcaca agcccgctcc ttaacgcttc gtcactgata tgggcgatat 2301661 tctccttatt gagccactcc gcagccaaaa tggacaaagc agcattttgt ctttgatggg 2301721 tgccaatcag agatgtccga atatcttcat agcatttctc ttccgttttg aatgaaaact 2301781 gttctcctgc aggcagagcc tcttcattga aaataacaca tgcatcatgc aatgactgga 2301841 acggcgcagc atgccgttcg gcttcatggc ggatgacctg taaagcttcc ggctgggtaa 2301901 ctgctgtaac gattggaata ccttctttaa taatgccggc cttttctcct gcaatttctt 2301961 caatggtgtt tcccaaaatg ttcatatgat cgtgtccgat gcttgtaatc acagttaaga 2302021 gcggttcaac cacattagta gaatcgaatc taccgcccag acctgtttca aaaataacaa 2302081 aatcgacctt atgaaactct gcaaaatata aaaatgcaca agctgtcata atttcaaatt 2302141 ctgtcggctg tccgtattcc gtttgatcaa gggcttcaac gtgcggtttc atttgattga 2302201 cgagtgctgt ccattcctca tctgaaatcg gtatcccgtt tacgctgatc cgttcattaa 2302261 acgtaataat ataaggcgat gtaaatgttc caaccgtata tccggcttcc tgcagcatag 2302321 aacggataaa agcgacagtt gatcctttac cgtttgttcc tgcgacgtgg aacgctcgga 2302381 tttttttttc aggatgtcct aaccgcgcca tcagctgttt cattcgacca agtccgggct 2302441 tcaccccgaa tttcagcctc ccgtgaatcc agctgcgcgc atcttgatat gcagtaaaca 2302501 atgataatcc cctcttttat aagacaaggc ggtttctcta gaaaccgccc cggcttttca 2302561 ttaacccttc agctcagcca ttcgtttttg aacagcgtca cgcttcgcca cataatcttt 2302621 ttctttttca cgttcttcat caattacgtg tgcaggcgct tttttcataa atccttcatt 2302681 tccaagtttc ttttggacac gctcaacttc ttttgtcagt ttatcaaatt ctttttgcag 2302741 acgggcaatt tcttcatcaa tattgattaa gccttcaagc ggaagaataa cctctgctcc 2302801 tgagacaacg gccgtcatcg ccttatcaac agcctcaata tcggtgccga ttttaagcac 2302861 gctcggattc gtaaagcgtt caacatatga acggttcgct tcgaggcggg acgctatttc 2302921 gtctgtgctt gttttaatgt acagttcaac ctgcttgctc attggcgtat tgacttcact 2302981 gcggatattg cgcacagaac ggatcagctc aacaagaagc ttcatgtcag ctgccgcttc 2303041 agtatcggta tgctccggca ctactgcagg ccattgactt actgtaatcg attccccttg 2303101 gtgaggaagg tgctgccaaa tttcctccgt taagaatggc ataaacggat ggagcagacg 2303161 catcgtttga tcaagtacgt aagcaaggat ggaacgggta gttttcttag ccgcttcgtc 2303221 ttctccataa agcggaagct tcgccatttc aatataccaa tcacagaaat catcccaaat 2303281 aaagttatat aaatggcgtc ctacttcacc aaattcatat cggtcagcaa gctgggtcac 2303341 gtgctcgatc gtttcattta atcgcgttaa aatccacttg tcagcgactg acttttcacc 2303401 tgacagatca agctcatcgt acgtcatgcc atccatattc attaatgcaa aacgggaggc 2303461 gttccaaatt ttattggcaa aattccaggt cgattccact ttttcatagc tgaagcgcag 2303521 atcctggcca ggagagcttc cagtcgcaag gaaataacgc agagaatcgg ctccgtactt 2303581 gtcaatcaca tccatcgggt cgacaccgtt gccaagagat ttactcattt tccggccttg 2303641 ctcgtcacgg attaagccgt ggattaaaac atctttgaac gggcgctcgc ctgtaaattc 2303701 aatgccttgg aaaatcatgc gtgataccca gaagaaaatg atatcgtacc ctgtcacgag 2303761 aacatctgtc ggatagtagc gtttaaagtc ttcagccgtt acatcaggcc agcccattgt 2303821 ggagaaaggc catagcgcag aactgaacca tgtatccagt acgtctgtat cctgttccca 2303881 attttcgctg tcttccggcg cttcaagtcc gacatatagc tcgcctgttt ctttatgata 2303941 ccaggcagga atacgatggc cccaccacaa ttgacgggag atacaccagt cgcggatatt 2304001 ttccatccag tgtaaatacg ttttttcgaa acggtcaggc acaaagttga ccttttcttc 2304061 ttttttttgc agctcaatcg ctgcatcagc aagcggctgc atgcgcacaa accattgtgt 2304121 agaaagataa ggctccacaa cagccccgct tcgttcacta tggccgacag agtgcatatg 2304181 atcctcgatc ttgaagagaa ctcccgcctc ctgtaaatct ttcacgagct ttttgcggca 2304241 ttcaaaacga tccatacctt gatattggag cgcattttca ttcatcgtgc catcttcatt 2304301 catgacaagg atgcgttcta aattgtggcg gttgccaagc tcgaagtcgt tcggatcatg 2304361 agcaggcgta attttcacgg cacctgaacc aaattccata tcaacatagt catcaccgac 2304421 aatcggaatt tcacgattta caatcggcag gatcaccgtt tttccgataa ggtgtttata 2304481 gcgctcgtct tcagggtgaa cggcaacagc tgtatcaccg agcattgttt caggacgtgt 2304541 cgtcgcaatt tcaattgagc ctgaaccgtc agcaagcgga tagctcatat gatagaatgc 2304601 gccttgaaca tccttgtaaa tcacctcaat gtcggatagg gctgtttttg tcgctgggtc 2304661 ccagttaata atatattcgc ctctgtagat caggcctttt tcataaagct taacgaatac 2304721 ttcccttacc gctttgctca agccttcatc cagcgtaaaa cgttcacggg aataatctag 2304781 gccaagacct aatttcgccc actggctgcg aataaagtca gcatattctt ccttccactt 2304841 ccacgtttct tcgaggaatt tttcacggcc taaatcgtag cgggatttgc cttcttcacg 2304901 aagtttcgcc tccactttag cctgtgtcgc gatgccggcg tggtccatgc caggaagcca 2304961 cagcacatca tagccctgca tgcgtttcat tcttgttaca atgtcttgca gcgttgtgtc 2305021 ccatgcgtgg ccaaggtgaa gtctccctgt tacgtttggc ggcgggatga caacagagta 2305081 tggctctttt gtctggtcac tgcccgcttc aaaaaatttg ccttttagcc aaaaatcata 2305141 tcggtctttt tcaaccgctg ccggatcata tttcgtcggc attgtttgtt cattcgtttc 2305201 catcataacc ctccagcatg tttaaaaatg gctgagaacg aaaaaagagc tcttcatccc 2305261 tgtaaaagga cgaaaagctc tttcgcggta ccaccttttt tcatgaactc aatcagttca 2305321 tgcacttata acggataacg ggtgtttccc gaatttctct actcttcttt caagaaatta 2305381 tgctcccggg cgaccttcca atcagacaac ataagaagcc tttcagcaaa cggcttctct 2305441 ctctgcatgc gccttttttg tactcttccc gttctaagca ggtgtattta tcagctcatt 2305501 gtatacatta tttatgttct ttattatagt aaaagtgttt ttgattcgtc aatcatcttt 2305561 tccaaaaaca ccgctttcta tacagatggg caggcaccta ttgcccaagt ttacatatga 2305621 tgcttgtaaa tgcgtagagg aggatgcacc gtgaagaaac gtttcagctc ttattcgctg 2305681 ccgccatggg taaggcaaat tcggcttgta tccgcacaag tgattattcc cattacgatt 2305741 tttcaaggaa tcagaaccat tttctttccg acaacctttg atgttttgct gctcgcaatc 2305801 ctaatctttt tagcttgcgc ccttcattta gaatggatat aaacaaacaa gtccgcgcca 2305861 ttaagacgtg gactcgtttt cagcctgaaa ttttttctct tgttcaatct gatgaatttt 2305921 catcacaaac ggctctatgt ttttcatttg ccaataagcc tttaataatt gtgtacattc 2305981 ctctttttca tgctgtcttt tcccagtttg ataaccgttc agcaccttgt acatggctgc 2306041 cggatatgcc atatagctga gaaaaaggct gacttccgct tcacgcaaag ggaatgattt 2306101 cgtatatcca taaaaccatt cgacgcattc cggacaagct ttcggaaagc ctctgaacat 2306161 ttttgtataa aagccgagca ggtcgttttg cggcggaccg acagatgctc tttcgaagtt 2306221 tgtaaaatat ccggtcccgg catcattata cagaaaatgg tgtatagaca ggctgccgtg 2306281 gttcattaca acccttgaaa cgtccttttc ctttgcggac tcataccagt cctccagccg 2306341 ttccagcgca aagttcaccg cggaaatggt ttcagaaaaa taggttatgg cctggagttc 2306401 aaagggagaa aggtaccatt ccttctccgc tctatccaca aactgctcat agaaaatttt 2306461 atcttgttcc cacttttttt tcgtttgccc gtaataacgt tcaatctcat cacgtctaac 2306521 ctttagttcc tgcgcggttc tctcgtgaag acgggctgtt tctctaaata aataagcatg 2306581 tttttgatcc cgttcttcct cttggtcaaa ttggagccaa ggcattaaat agtagatatc 2306641 tccgtattgt atgcctgctg agaaaaactc accgctattt gttctgtaaa cgggaacgaa 2306701 tgaacgaaag cctttttcct caatcgccac catatgatct gtaaaatgct tgccgcgacc 2306761 ttctttcaat tttttcaggg caaatatgcc gtagtctgta tacactttcc aaacaagagg 2306821 actgacaggc tcaataaatt gagcagtcag tccgtattcc tgaagaaccg attgggtatc 2306881 ttccatttca ttcaccacat tttccgatca cttacggttt acgcatggct atttttatat 2306941 tgaggaatat agagaatctg tcctgctttt aattcatcat ccaaggctaa agaattcatc 2307001 ctgatcagct gctgggatgt aatttcatac cgttcgcata aacgctcgat cgtatcttcc 2307061 tgctgcacaa tacaaatttt cattctcgaa aactcatccg cttcttttgt aaagagtttt 2307121 gttaaataaa gagaattatc actttccttt gtttgaggtt ccttcgtttc agcagcagga 2307181 gcaaccctag gaacagcatc cgtttccttc ctttcagtct cagaagattc aggcagctgg 2307241 aaggattgaa aaggtgtttc ttccttaggc tcttcagctg atggtgtttt tctcacttca 2307301 atttcgaagc tctcttcctc ttgttcttcc tcctccagca gcttaggcgc tgaataaaaa 2307361 gaatcctcct cttcttgttc aggcaggaag gtacggtatg ccggttcagg caattcttct 2307421 tgagatgcct cctccgagct tgttttttga ttgaaatgga aatgtaaatc ggcattgtca 2307481 ttctccatat atacagctga agctgtttct ctgctatctt ctatggagag agcggcctct 2307541 gatacactct ccaaagcttc atccggttcc gcctcttctt ggcaaagcgc aggatcagcc 2307601 tgatccgatt gagctgcttc ttcattttga gcctcttggc gcagcgcata ttcatgatta 2307661 ggagacactg ttgtttcctc tttttccttt gcaatcacag tctctgaatg aagctcagct 2307721 tccaaagcag gcgattcttc tgctccaacg tgttcacgaa gctcagtctc cgctggagag 2307781 tctgcttctt cacgaacatc cgctattgca gctgccggct ctgccgtttc tttttttgct 2307841 ttaacgatct cttgaatctc tatttctgaa ggatcaggtt ctggctcaga ttcttctgtt 2307901 tccgattcag cacgaacctc cgtttccggc acagcaagct cttctgactc ttcttcctct 2307961 ttcacatctt ctctggcctc tggttctgaa gcaaccgatt caggcggctc agattctgct 2308021 ttttctgtct ccagttcttc acggagcccc gctttcgaga taaaaagttc tggcggttcg 2308081 gctggcggtt catgctgaag aactgcttcc tctgccgatg atgcacccgg ttcttctact 2308141 acactatgtg ccggcggctc tgaaagctct tcctccctga atgccgcagg agcttcatat 2308201 aaaggtatct ccggctcttt gtcttgcgta tcgtccaaaa gcccttcgat cgctaaatca 2308261 gcttgaattg ttaaaatgcg cgaatccgtc aattgatagt caaatgcgtc aataaagacg 2308321 aagacatcct gtaaatggct cactttattt ttcggaatgg taatatccac aggaaaacag 2308381 tgagtcagtt ccgcacttcc atcctctctc tttctgactt gttcaacaaa ccgcttatct 2308441 gtataaatct cttcggtatg tttgttttga tctatgttgt actcacctgt aagttcaagc 2308501 gatcctatga ttgatacata atcatttact tcctgaaccc taatatcagg atctaatgaa 2308561 atagaaagca gttcagaaac ttcctgtcct ttttggaaac agatcgattc ttctacagaa 2308621 aattgcaatc gatgattttg cggcaagttc atatcctcct ttcatctaat ccttaaaatt 2308681 agatgtcact aaaggtgtat gtatgaactg gagaaaatat gagtgggaga gcacgaaaaa 2308741 accggcacaa ggagtccttg ataccggttt tcactcttat ctgcggctga tctcagcaaa 2308801 tactttctca gctgcctgga ttgtgttttc aatatcttca tcagtatggg ccgttgagag 2308861 gaaaagacct tcgaattgtg atggcggaag gaatacccct tcatttgcca tccctttata 2308921 atagcttgcg aacagcttca aatcagatga tttcgctgtt tcataattga tgactggttc 2308981 gtttgtaaag aagaaaccga tcatcgaacc tgcacggtta aaggtatgcg gaatgccatg 2309041 agccccggcg gtttttgaaa ttccttcttc cagtctgtcg ccttttttga tgaaattctt 2309101 gtaggattca ggtgtcagct gtttcaatgt ctctaagcca gccgtcatcg caagcgggtt 2309161 gcctgacaat gtaccagctt gatagatcgg accgcttgga gcgatctgct ccatgatttc 2309221 tgcctttccg ccataagcgc cgacaggaag tccgcccccg attacttttc ctaaacaagt 2309281 cagatcaggc gttacgccga agtagccttg agcgcagtta taatcgaccc ggaagccagt 2309341 catcacttca tcaaaaatca gcagggagcc gtactgctca gtgatatcac gcagaccctg 2309401 aaggaaacct tcttgcggcg gaacaacacc catatttccg gcaactggct ctacaatgac 2309461 tcccgcaatg tcttcaccga attgctggaa agcaagcttt acactttcta aatcattgta 2309521 cggaacggtg atggtgtttt tcgcaatgcc ttcaggcacc cccgggctgt caggcagacc 2309581 gagagtggca acacctgaac cagctttaat caagagagaa tcgccgtgtc cgtggtagca 2309641 gccctcaaat tttaaaatct tgttgcggcc cgtatagccc cttgccaaac ggagggcact 2309701 cattgtagcc tctgttccgg agcttaccat tcgtacaatt tctacagatg gcacacgatc 2309761 aatgacgagc ttagccagtt cattttctac ttcagtcgga gcaccaaagc ttgtcccgta 2309821 ttcagccact tttttgaggc tttctacgac gcggtcattt gtatgcccta aaattaaagg 2309881 cccccatgac aagacgtagt caatatattc attcccgtca atatcaaaga ttttcgagcc 2309941 ttttccgcgc tccataaaaa tcgggtccat gtctaccgat ttaaatgcgc gaacgggact 2310001 gttcacaccg cccggcatga gtttttgcgc ttctttaaaa gccgtttttg atttttcata 2310061 gcttctcatc tgcctcaact cctgtcaact gaataaaatt actccgcaag ccatttcgct 2310121 gcgtctttcg catgatacgt aataatcagg tcggcacccg cgcgcttcat gcttgtcaaa 2310181 atttccaaca caatttcttt ttctttgatc cagccgttct gcgctgcagc cttcaccatt 2310241 gaatactctc cgcttacatt ataagcgacg agcggcaaag taaactcatt ttttacgtca 2310301 cgcatgatat ccatataaga aagcgaaggt ttgacaatca aaaagtccgc gccttcctca 2310361 acatctgatt gtgcttcgcg gagtgcctcc atacggttgg cagggtccat ctgatatgtt 2310421 ttgcggtctc cgaattgcgg tgtgctgttt gctgcatcac ggaacggacc gtaaaactca 2310481 cttgaatatt taacagcgta agacatgatg ggaatattga cgaatccttc tttatcaagt 2310541 gcttctctga tcactgtaac aaatccgtcc atcatgtttg atggcgcaat gatatccgca 2310601 cctgctttcg cttggctgac agctgtctgc gccaaaagct ccagcgattc atcattgaga 2310661 atgactccgt ctttgacaag tccgcaatgg ccgtggtctg tatattcgca caggcacgtg 2310721 tcagcgacaa caaccatttc agggaagtgt tctttaattt ctgtgatggc tttttggaca 2310781 attccgtgat catggtacgc ttgtgttccg caatcatctt tttcttccgg gatgccgaac 2310841 acgataacag attgaatgcc cagtttgacc agctccgcta cttcatcctt caataaatct 2310901 aatgatacat ggtgaacatc aggcattgac ggaacagctt ttttgccttc cagcccttca 2310961 acgacaaaaa tcggatatat aaaatctgat ggatgcaaac gtgtttcctt taccatttct 2311021 ctcattgctt ttgatgtccg caggcggcgg tgtctattaa atgattgact catattctct 2311081 cttcctctct tgacatgctg cacattaact caagcatgcc atctattgta aatgtatcag 2311141 gcgtatgcga tgtgatgccg tacgtcagaa gggcatcatt tgttaaaggc ccaatgctga 2311201 tacaggccgt cccattcgcc ttccactttt ttaattcttc tcccaagaca tgcataaacg 2311261 tatgtacggt tgatgaactc gtaaatgtta catagtcaaa ggaatattga cccgcagcgt 2311321 ctttcaatgc ctcaatgcct tcttcatccg gaatcgtttc gtagagaacc cattccttta 2311381 cttcaaaacc gagcgggaca agctcttgtt ttatcacatc acgtgacaaa ttccctttca 2311441 tcacggtaat ggtctccccc ggttcagcat gctgcttaag agcgtcagcc aattgttcag 2311501 caatatactc ctgtggcatc acatcaaccg atacgttatg catttttaaa cggcgcgcgg 2311561 ttttttcacc gacggctgca atttttttat gcgcagggag aataagctga ttttccttca 2311621 gataagaaaa aaagaagtct gccccgttca cacttgtaaa aacaagccag cctggcgcgg 2311681 caagatcctc tcttacctgt tccgcaacat cattcggcaa agcgcggcga aacgtaatca 2311741 aagaggttaa aaccgcttta ccgccaagcg cctccacttt ttgctgaaat gatgctgcct 2311801 gtgccttatt ccgggtgaca agcactgttt ttcctttcaa cggaaaatca ttttccatcc 2311861 tcgtcaagct cccgttttac acgatcaatt aaatcttttg ctcctttgtc agccataaga 2311921 gcggcacagc gctttcctac ttcctccgga tcgtttccgg tgacggtttc tttaaaaatg 2311981 attttgccgt caggtgaagc gacaagacct gtcatttcaa tttcatcctg tccatttaac 2312041 acggagtagc ccgcgatcgg aacctggcag ccgccctcca tcgcgtttaa aaaagcacgt 2312101 tccgctaaga cagtccgttt tgtatattca tctgtaaact gagaaaacaa cgccaacagc 2312161 tcttcatccg attctcggca ctcaatcgcc agggctccct gccccacagc aggcaaacag 2312221 cgctcaggct caaggaattc ggttacgaca tcttgcttcc aacccattct ggaaaggccg 2312281 gcagccgcta aaataattgc gtcataatcc tctgtttcca gcttttgaag tcttgtatct 2312341 atattacctc taatccattt aattgtaagg tcagggcgct caatcaaaag ctgcgcgctt 2312401 cttcttaaac tgcttgtgcc aatgacagca cctttcttca tttctgaaag ctttacgcga 2312461 ttctttgaaa taagggcatc acgcgggtcc tcccgttcag gaatacagcc gatcacaagg 2312521 ccttcaggca aaacagcagg catgtccttc atgctgtgca ctgccatatc aatctcttcg 2312581 tttaaaagcg cctgttcaat ttctttgaca aaaagccctt ttccacccac ttttgagagt 2312641 gtaacatcga caatccggtc gccctttgtc acgatctctt taatttcaaa agcaaacgaa 2312701 ggattgattt ccttcagttt ttgaataacc cattttgttt gagtcatagc gagtttgctc 2312761 cgtctggaac ctactttaat cgttctcatc atttctttcc tcccgaatct gcttgggaca 2312821 tcgtttaact gaaccaatgg aattgcgaca ggcttccaag caggaaataa ttgatcatca 2312881 gcaccagaaa acaagccgta ttccacagtg cagcgacctt tccttgcagc tccttaatca 2312941 gcctgatata aagataatag ctgtacagca gcaggacgac aaacgaacca agcactttgg 2313001 cgtcaaacca atacagcgtt tctagtgaga catacgccca aatgacgccg agaatcaaac 2313061 tcagcagcag catcggaacc ccaatgacat ttaaaacata cgccatataa tcaagcttag 2313121 ataaatcttc tattctcaac agccattttc cccacttttt ctttttcagc agatgatatt 2313181 gaaacatata tagcacagaa aaaacgaaag aaagggaaaa agcgccgtat gaaagaatcg 2313241 ccattgtaat atgaatcacc aaaagctcgg atacaagctg cccggaaaaa gcagctgact 2313301 gctgctctgt cggtgaaaat gtgtgaatgg cgatcataga aaatcctata acatttgtaa 2313361 aaaacacgat aaagtcaaca cgtaaaagct ttgtcagtac aagtgacagc gtgacaagca 2313421 cccaggcata aaaataaagt gcctctgtca catttaatac cggaaaccgc cccgtcaccc 2313481 acataaaata ggccaaatac acggtttgca gagtccagac aatagaaagc aaccagaagg 2313541 ccatttttcc agccttccgg ttgtgttgaa gaaaatctat aaaataaaag agtacactta 2313601 acgcgtaaat gacgattgtc ccctcattaa gtcttgccat tgcagtatca atcattcagc 2313661 tttcactcac ttacaagtgg gctaaagccc gcttttgatt cagccttctt aaaagagtgg 2313721 accttctggc tgctttcaac ggttttcatc atttgacggc ccgcagcttc ttcaatatca 2313781 aaaatctgca taaacaacgc gagcttttct tcagaatcag catctgccgc aagctctttc 2313841 acctttaaaa tcggatcacg aagcatttgg ttaataatac ttttggtgtg tttgttcaac 2313901 agttttttct ctcttgtgct taagtgaggc agcttacgct caatgctgtc catcgtttct 2313961 gactggatgg caagcgcctt ttcgcgcaat gcagaaataa caggcacaac accaagtgta 2314021 ttcatccatt gtttaaattc cacaatggtt tcttcaatta acagttcaac tttttcagct 2314081 gtttctctcc gctctttcat gttcgcttct acaatgcctt ccagatcgtc gatatcataa 2314141 agaaaaacac cttcaagatc attcagcgcc ggatcaagat ctctaggcac ggcaatgtcg 2314201 accataaaca gcggacgtcc cttgcgaagc ttattcgcgt tttccatcat ctctttggac 2314261 acgacaaatt cacttgcacc ggttgaactg attaaaatat cagcctccgc aagcgcgctt 2314321 tcaagctgat tcaagcttct cgcttcacct gaaaaacggt ctgcaagctc cttcgctttc 2314381 aagtatgttc ggttaatgac agtgaccttg ccgattccct gtccgtgcag gttttccgca 2314441 gcaagctcgc ccatttttcc cgcaccgaga atcaatatgt gcttgcttga aagatttccg 2314501 aagatttttt tggcaagttc aactgcagca tagcttactg acaccgcatt tgagccaatg 2314561 tctgtttcgg cgtgagtccg tttgcccact gtaactgcct gcttaaacag ctcattaaaa 2314621 atagtcccga tcgttttttc ttgctgagct gttttaaagc tgtcgcgtac ctgtccgaga 2314681 atctgcgttt cgccaatcac catagaatca agtccgcagg ctacacggaa taaatgctca 2314741 acagcggcat cgctctcata aaacgttaag aacggtgaca gctcttcttt gcttaattga 2314801 aaccaatcag ctaaaaactt ttttatataa taacggccgg tatgaagctg gtcgactacc 2314861 gcataaattt cagtgcggtt gcaggttgag acaatgatgt tttcaagaat gcttttctct 2314921 tctttcagct gcaccattgc ttctgccagc tcattcggct gaaaacttac tttttcacgt 2314981 atctcaatag gggcggattt ataatctact cccacaacaa gtatatgcat cgctctaatt 2315041 acacccccaa cacccaatct taatttataa tcattctaac atagaactca ttatttataa 2315101 taattataac atagtttctt tcacaaaatg tgaacagatt ttaaaattct tatgctatat 2315161 tagaaaaagc ttcagggaaa agaagcattc ctattgacaa taccaaaaac agcagaaatt 2315221 tactacacat cagctctaaa aaacaagaag gtgatatgca tgaaacaaaa atcaatttta 2315281 ttcccttgtc tgctgcttgc cgcttctgta tatgcatggc tagaaagcgg ccaagccgaa 2315341 ctgttttcag ggcaggatca atggcctgtt ctcctcatgc tgttaggcgc agcctttgta 2315401 tatcaaggaa aaaaagaagc cgtcacaccc cattttttta tcggtttgct tctcttcggg 2315461 atcggtttac acttttttgc caagccgaaa tgggtatggt ggccggatga ttttgaaatg 2315521 ctcctcttta tgatcggctt ctcacttctc gtttcaaccg ttcaaaaaaa agaatatgta 2315581 tatgaagctg tgtcgatgat ttgtttttcc ctgtttttgt actttttcaa acaaattatg 2315641 gcatggcttg agtctgcgca tattccaaca gcgcttctga aggagtattg gccgtttgtc 2315701 tttattggaa tcagtttatt gttattattg ataaaacgaa aaaaatctat acgataaata 2315761 aaaccggtag aggatcctct accggtttat catttttttg atcgctcccc aagcttcgtc 2315821 ttttcccttt ttcgtttctg aagaaaagag gatcagctcg tcttccggat caatatttaa 2315881 tgtttgtcgg acaaccttcg cgtgtttgtc ccatttacct ttcgggatct tatccgcctt 2315941 tgtagcgata acaataacag gaatgccgta atactttaaa aattcataca tctgtacatc 2316001 atcattagat ggcgcatgcc gcaaatcaac gatctgcacc acagctttta attcctcgcg 2316061 tgtcgtgata taggtttcaa tcattctgcc ccatgcttca cgctcagact ttgacacttt 2316121 ggcaaaaccg tagcccggca catccacaaa atgcagctca tcattgataa tgtagaaatt 2316181 aagcgtttgt gtttttcccg gctttgatga cgttctcgca agatttttgc gattgattaa 2316241 tgaattgata aaagacgatt ttcctacgtt cgatcttccg gccaatgcga tttccggaag 2316301 ccccccttca gggtactgtt ccggttttac tgcactgatc acgatttctg actttgtgac 2316361 tttcatttct tctctcctac taaggcatgt tccaaaacct cgtctaagtg ggacgccaat 2316421 ataaatgtca gcccctccct gacgctttcc ggaatatcct ctatatcttt ttcattatct 2316481 ttaggcgcaa taatggtcgt taatcccgct ctatgtgcgc caagcgcttt ttcctttaag 2316541 ccgccgatcg gcagcacgcg cccgcgaagc gtgatttccc cagtcatgcc gacttcacgc 2316601 gaaaccgccc gtcccgttaa agcagaaaca agcgctgttg ccatcgtaat accggctgac 2316661 ggaccatctt ttggcaccgc accctctggt acatgtatat gaatatcata cttctcatga 2316721 aagtcaggtt caatgccaag ttcttctgtt ttggatcgca catagctgaa tgcagcctga 2316781 gcagactctc tcataacatc tccgagcttt cctgtcagga ttaatttccc ttttcccggt 2316841 gaaagcgata cttcaatcga aagcgtatct ccgccaacgg ttgtatacgc aagccctgtc 2316901 actacaccaa cttgatcctc tgtttcagct tgtccatatc tgaaaatgcg ttttccgata 2316961 aaatcttgaa ggttcttctc agtaaccgta attcgttttc gctcttcagc aacaatggct 2317021 tttgcagctt tacggcaaat tgcggcaagc tggcgttcaa ggcttcttac acccgcttct 2317081 ctcgtatagt aacgaataat atcaagaatc gcctgatcac gcagctgaag attgcttttc 2317141 ttcagcccgt gttctttgat ttgctttgga agcaagtgat cctttacaat ttcaagtttt 2317201 tctatttctg tgtagcctgc gatattaata atttccattc tgtctctgag cgggcccggg 2317261 attgtggcca aattgttcgc cgttgcgata aacagcactt tggataaatc aaaggtttct 2317321 tcaatatagt gatcactgaa gctgctgttt tgctctggat caagcacttc aagcatagcg 2317381 gatgatgggt ctcctctaaa atcagatgac attttgtcaa tttcgtctaa taagaagacc 2317441 ggattcagct tgcccgcttt tttcatccct tgaataatac gtccaggcat tgctccgaca 2317501 taggtccgtc tgtgtccgcg tatctctgat tcatcccgaa ctcctccgag tgagattctg 2317561 acgaatttgc gtcccaagct ttttgcaatt gatttggcta aagacgtttt tccgacacct 2317621 ggaggtcctg ccaaacagag aatcgggcct ttcagggatt ttgtcagctt ctggacagcc 2317681 aaatattcta aaatacgttc ttttactttt tcaagcccgt ggtgctcttc gtccaagaga 2317741 cgtcctgctt ctttcaaatc aagcttatca tctgtttcat ccgtccacgg aagagcaacc 2317801 agccagtcga tatagttgcg gatcacagag ctttccgcag aacttgacgg aattttttca 2317861 tatctgttca attctttaag cgctgtttct ttcacatgat caggcatgcc tgcttcttcg 2317921 attttttccg tcagcgtctg aacttcgcca gttttgcctt ctttatcgcc aagctctttt 2317981 tggatcgcct tcatttgttc acgcaagtag tattccttct gcgtacgctc catcgaacgt 2318041 ttgacgcgct ggccgatttt tttctcaatc tccagcactt ctttttcatt attaataaaa 2318101 tcaatgacct tgttcagcct gtctttgaca tcagccgttt ctaaaatatc ctgcttatcc 2318161 tttagtttaa ggggcagatg agaagcaacg atgtctgcca ttctccccgg ctcttcgata 2318221 tcagtaaccg cagcgtacgt ttcggccgag atttttttag aaatttttat gtactgatca 2318281 aagtggtcta gcaaagtccg catcaatgct tcgtcttctg tatcttttga atcatcttca 2318341 tgaataagtt gaatgtcaac cgacgtgtaa tcctcgtgtt cattgtattt gacgatatgg 2318401 gcgcgcttga ggccctccac caacacacga atcgtaccgt tcggaagctt cagcatttgc 2318461 ttaatttttg tataggtgcc gacagtgaaa atctcgtctt caccaggttc gtctatcgaa 2318521 atatcctgct gagtggctaa aaatatcata tgatcatgca tcattgcctg ttcaagagcc 2318581 tgaaccgact tgtcacgtcc tacatctaaa tgcaaaacca tcgtcgggta cactaataaa 2318641 cctcttaaag ggaggagcgg gatgctgcgt tttaattctt ctgccatgtg actgacacct 2318701 ccgtgacttt agtatgaacc attataatac aactttttca tccttgtaca ataaacggca 2318761 tggttccatt ttctataaaa cagtctcctc gtagtatacc ctttctttct gatatgaaaa 2318821 aggaaaagat gtccttcatg aaaaaaaccc tattatcaaa atagggttta aacggattct 2318881 ttattgattt cgatatgaaa cggtttttgt tccgttggcg gattcaccaa aatttcatca 2318941 agcacttctt ggaacgtctt cactgcaata atctcgatcc cgtcaatctg ctttaagatg 2319001 gcctgctgat tttcatatgg gataatcacc tttttcgcac cggactgctt ggccgctttt 2319061 attttcggaa tgacgcctcc gatgggtttc acaagaccgt tcaggctgat ttcgcccgtc 2319121 atcgcaacgg tattgtcaat aggaattttg tgtatcgccg agaaaatccc cgccgccatc 2319181 gcaatgcctg ctgacggccc atcaatcgga atccctcctg ggaaattgat gtgaatatca 2319241 taatcagaag gcttcattcc cattgtccgg agcacggtta atacattttc aaccgaaccc 2319301 ttcgccatgc tttttcgcct gatcgatttt gattggctgc cgatgctttc ttcttcagct 2319361 attcctgtga tgttaattga tcctttatct tgagccgcgg ttacacttac ttcgatttcc 2319421 agaagcgatc cgctgttagg cccatagact gcaagcccat ttacaatgcc aacctgtggt 2319481 tcaacaccga ttttttgctc gtgctttgga gtaagctgac tggagtgaat gacccattca 2319541 atatcctcaa tcgtaatgtc ctttcgattc tccgttacag ccatccccgc tgcgatttga 2319601 atcatattga cggcttcccg cccgttccgc gtgtagctgg tcaaaagatc cagtccttct 2319661 tcggagatat ttttttcaat tttatccgct gctgttttgg caaccgtttt cagctcgtcc 2319721 ttttcaagct cgcggaaaaa aacctccaaa cagcgggacc ggatagctgg cggaatttcg 2319781 tttggcattc tcgtggtcgc gccaatcaag cgaaaatcag ccggcagccc attttgaaaa 2319841 atatcatgaa tatgattcgg aatttgtgta ttttcctcac tgtaatacgc actgtctaaa 2319901 aagacttttc tgtcctcaag caccttcagc attttattca tttgaatagg atgcagctcc 2319961 cctatttcat caataaacag cacaccgcca tgggcatggg tgacagctcc ctgcttcggc 2320021 tgcggaatcc cagcctgtcc catcgctccg gccccttggt atatcgggtc atggacagag 2320081 ccgatgagcg gatcggcaat tcctctttca tcaaaacggg ctgttgtcgc atcgagttcc 2320141 acaaagacag cctgctcttt aaacggtgat tgtttatgtt tttttgcttc ttccaacaca 2320201 agccgcgcag cagccgtttt cccaactccc ggtggcccat agacaatcac atgctgagga 2320261 tttggcccgc ataaagccgc ctttaatgct ttaatgccgt cttcctgtcc gacgatatct 2320321 ttaaagcttt tggggcggac cttctcagat aatggctcgg acaagctgat agcgcgcatt 2320381 ttccgaagct gctccatttc cttctttgat tctttatcta tcgtgacctt ttgtgtcctt 2320441 tgatttttaa gcaaattcca aaaatacaaa ccgatgatga tcccaaaaaa cagctgaata 2320501 aataacgcga tccctgtcca actcatggtg gtccctcctg aaaaacaatt tatgtatcca 2320561 attcattcct ctgattgcta gtatctccca tagaagacgg gaataaacgt ttttccggaa 2320621 gagttgcatg caaaaaaacc tcctgagtgt taccactcag gaggtttgtg cttatcttta 2320681 tgcagatgtt ttatcttggc ttacctcagt gccgtctttt aataagaggc gaggaggctc 2320741 tccgtgtgtc acagttgccc cggtgattac acatttttca atgtcatcac gagaaggcag 2320801 ctcaaacatc acatcaagca tgatgccttc aatgatagaa cggagtccgc gtgctccagt 2320861 cttgcgttca attgcttttt tagcaatttc agaaagcgct tcttcttcaa actcaagctc 2320921 aacgttgtca agctcaagca ttttcttgaa ttgcttaaca agagcgtttt tcggttttgt 2320981 taagatcgca accaatgctt cttcgtcaag cttttcaagg cttgcaataa ccggaagacg 2321041 tccgataaat tcaggaatta acccgaaacg gagcaaatct tctggaagca cttttgaaag 2321101 aagatcttct ttctcaagat cagcagcttt attgtcggca ccgaatccaa tcactttttg 2321161 gcctaaacgg cgtttgatga tttgttcgat accatcgaaa gctccgccgc aaatgaacaa 2321221 aatatttgtt gtgtcaattt gaatgaattc ttgatgagga tgcttacgtc caccttgagg 2321281 cggtacgctt gccactgtac cctcaagaat tttaagcaat gcctgctgta caccctcacc 2321341 tgacacatca cgtgtgatag acgggttttc agattttcta gccactttat cgatttcatc 2321401 aatatagata atgccttttt cggctttttc cacatcataa tcagcagctt ggatgagctt 2321461 caagagaata ttctctacat cttcacccac gtatccagct tcagtcaaag atgtagcgtc 2321521 cgcaatcgca aacggcacat ttaaaatgcg agccaatgtt tgcgccagaa gggttttacc 2321581 gcttcccgta gggccgatta atgaaatatt actttttgaa agctcaacat catcaacttt 2321641 gctgttggag ttaatgcgct tatagtggtt atacacagca acagcaagtg atttcttcgc 2321701 ttgatcttgg ccgatgacat attcattcaa aatttcgcga atttcctgag gctttggtac 2321761 gtctttaaat tctacttctt cttctgttcc gagttcttcc tctacaattt cagtgcagag 2321821 ttcgatacat tcgtcacata tatatacacc aggtccagct acaagcttac gaacctgatc 2321881 ttgtgttttt ccacagaacg agcattttaa ttgtcctttt tcctcgttaa atttaaacat 2321941 tctttcaccc cttaatcttg tctcactttt tcttttaccg gcagagcaaa agaaaatgat 2322001 tcttgaaacg aacgagtatg tattgcattt taccatactt tccaaaaaga cggtaacaat 2322061 gtgtttctga cttgcacatt ctatatgtat gacaaaaaac agccctgcat taactatatt 2322121 gccccaagaa aaagagataa ctcataattg tacaaaacaa ggcacgaatg attcgcgccc 2322181 tgttttatta gtactattat tatgcaccat attaacggtt ttctacaaga aaatcaattg 2322241 ctttgcgaac ttttaaatct tctttcatcg cgtcagtaga accgatggct tgtttaatat 2322301 tttcaacagg catgttgtat gcttcagcca tttttgtaag ctcagcatca acttcctcat 2322361 ctgatacttc aaggttttcc gctttcgcaa tcgcctcaag agtcaggtta gattttacgc 2322421 gtttttcagc atcttctttc atttgctctt taagcgcagc ttcatcttgg cctgagaatt 2322481 gagtgtaaag ctcaaggttc atgccttgca tttgcagacg ctgttcgaat tctttcagca 2322541 tgcggtcaag ctcagtgtcg accattgctt gaggcacatc gatttcagca ttttcagaag 2322601 ctttcagaac aagctcttca cgcaatttag cgtcagcttc gttttctttt gcttcttcta 2322661 aacgtttctt tgttttttca gttaattcag caagtgtttc cacttcttca tcgatatctt 2322721 ttgcgaattc atcgtcaagc tcaggaagct ctttcgcttt gatttcgtga attttcactt 2322781 taaacacagc tggtttgcct gcaagatctt cagcgtggta ctcctcaggg aatgtcactt 2322841 caacatcctt ctcagcacct gcttcaaggc caactaattg atcttcgaag ccagggatga 2322901 atgaaccaga acctacttct agagagtagt tttcagcttt tccgccttcg aaagcttcgc 2322961 cgtcaacgaa tccttcgaaa tcaagaacaa ctgtgtttcc ttcttcaacg gcgccttctt 2323021 cttttacaac aagctcagct tgacgctctt gaagggcttt tagttcgttt tgaacatctt 2323081 cgtcagttac agttgtgtcg tctttttcaa tgcccaggcc tttgtattcg ccaagcttca 2323141 cttcaggttt tactgttact ttcgcagtga agattaagct ttcgcctttt tcgatttttt 2323201 caacatcgat ttcaggacgg tctacaggct cgattccagc ttcttcaacc gctttagggt 2323261 attctacagg aagaagaata tccaaagcat cttggtaaag agcttctacg ccaaagcgct 2323321 gttcgaataa tccgcgagga attttacctt tacggaatcc aggaattgaa acttgtttta 2323381 ctactttttt aaatgcatca tcaagtgctg ttttaaacgt ttcagcatca acttcaaccg 2323441 ttaaaacgcc ttcgttgcct tcttgttttt cccattttac agacatgtgt ttccctccaa 2323501 aaatctattc aggttgtgtc ggtcttccat tctaaagcaa tcattcggct tcgtccaaca 2323561 aaaacaaagc tgccaaagat cagaatcatt atgtatagat gttaataatg aactgcaaag 2323621 cctgtccaac cgtatttctt ataacccgtt atacacaaat acaaccacta tattataaca 2323681 taacacatag cgctttcaac tatatggcgc gatttacaaa taagaaattt cttcaatatc 2323741 ttttaacatt gtgcaagctt catcgagttc tctgtctgta aattcataca tcatatgaag 2323801 ttcttcgctt tcaatttcaa tcccgtgcat ctcgtaaccg actttatgaa gggcagccgc 2323861 ccaaaggtca gccgacagca atttcggctg gaacggatat aaaacgtaca aatgtcttct 2323921 ccacaattct tctactgctg catataaggt tggattttca tttccaagtg tctcatctag 2323981 caccctgaga acacggtgaa gaatcggcgc ggcatcaggc ggaacaatct ctgacggttc 2324041 aattgtcaac gactcgccaa atttactaat gtgtacaggt ttactgtact catgctcagc 2324101 caacagcatg acaatcatcg ttttgataat cggatgggct gaggggtctt ggaggattgt 2324161 tttgagcaat cctgtatact ttgctacgtt acggtctttt aaggaatgaa tgagattcat 2324221 ttgctcctca gggcttgcca gcactttctc ggtgtcaatt gtatcctcat attcttcggc 2324281 ccaagcctcg tcctcacgat ccggatcggt cattttccgg ctgaaatcca gcagcttata 2324341 aaattgctcg gcactttctg ccggcagctg attttcttcc aaaacggctt caatggtgct 2324401 tttgacttct tcgtactttt tgagctgaat taagatggtc atgtacacct gcaaaaccgt 2324461 aaaataatgg ccataacctt ctttgagcat cttctcgcac acgctttctg cctcttccag 2324521 ctcgcccagc tctaaaaagc agatggccat ccctaagtga agatcggatt cagtatcatc 2324581 atatttcatc gcttctgaaa acagttcaag cgcttcttga tacttttttt ccttgagtga 2324641 tgacatccct ttttccacaa ggcggtcttt cagatgagga aaaggaataa tttttgcgtt 2324701 tttcttgtca tgcgtcatac ctatattcct ttcaggcatt tattttgttc aagtgtatca 2324761 acacctgtga acaaaaacaa gaaatgaaag gtttcaccag gcaaaaaaag ccgccggaca 2324821 aataccggcc gctttttcag gcttgaagcc aagagcttct ttgtgattca aattgcttga 2324881 tttcatcttc cagcagcagc gttaatgaaa tttcatcata tccgttgatc agcatctctt 2324941 tccaatgcgg atcaacttca aatgaaattt gattgccttc actgtcatga atcagctgat 2325001 tttcaaggtc aacagtcatt tgcaatgact ggttttcata ctggccgaca agctgtttcc 2325061 aattgtcata tggcatgcgg atcggaagca tgccgttttt aaagcagttc tgatggaaaa 2325121 tatcagcgaa tgacggcgca atgataattt taaacccata atcatcaagt gcccacggag 2325181 cgtgttcacg cgatgacccg cagccgaagt tttctcctgc tattaaaatg gaagctcctt 2325241 gataaacagg ctggtttaat tcaaattcag ggttcggttc accattcgca tcatatctcc 2325301 agtcaaagaa tgcaaaacgt ccgtagcctg ttctttcaat cctcttcaaa aattgcttag 2325361 gaataatctg gtctgtatcc acattgatcc gatttaatac ggctgctttc cccgtatgtg 2325421 atttcaaagg ttccatctcg cgcactcctt acacaactgt tttttcctga taaaactttc 2325481 tgacatcaac gaagtgtccg tgaatggcag ccatcgcagc cattgccggg ctgacgagat 2325541 gtgttcttgc accttttcct tgtctgccct cgaagttgcg gttagaggtt gatgcacagc 2325601 gctctccctc aggaacaaca tcattattca tactcaaaca catgctgcag cctgactctc 2325661 tccattcaaa tccagcttcc aagaaaatct ggtcaagccc ttctttttca gcctgaagct 2325721 tcacgctttg ggatccgggc acgacgatgg cccttacgct gtcagctacc ttcttccctt 2325781 tgatcatgtc agcagcctgt cgaaggtcag tcatgcggga atttgtgcag gaaccgataa 2325841 atacgtgctc cactttaatg tcttcaattt tttggtgagg agtcaatccc atatattcat 2325901 aagcacgaat cgcttctttt ttatcgtctt ctgcagaaaa gctttccggc gcaggaactt 2325961 cagaatcgac aggaagaacc attcccgggt taatgcccca tgtcaccata ggggaaattt 2326021 tgttgccgtc aaggacgata gatttatcgt aaacagcgcc cgggtctgtg cgcagcgcct 2326081 tccattcctc tacggccttg tcaaattctt cgccttttgg cgtgtacttg cgatttttgc 2326141 aatattcaaa cgtcacctcg tcaggtgcaa tcaaacctgc tcttgctcct gcttcaattg 2326201 acatgttaca aacagtcatt cgttcatcca tcgtcatatt tctgaatact tccccagtgt 2326261 attcaatgac gtagcctgtg ccgaatttca caccgtattt gccgatgaca gcaaggatga 2326321 catcctttgc cgttacccct ttttgaagcg ttccatctac gcgcacttca agtgtttttg 2326381 gacgctgctg ccaaagtgtc tgtgtggaaa ggacatgttc aacttcactc gtcccgattc 2326441 caaatgcaag agcgccgaaa gcgccatgtg ttgatgtatg actgtcaccg cacacaatcg 2326501 ttttccctgg aagcgttaag cctagttcag gtccgacgac atggacaatc ccttgatcca 2326561 cactgtgaag atcggcaagg cgcacgccaa attcctcaca gtttctttca agcgccgtta 2326621 cctggcgttt cgcaacttca tcctttatct caaaacgatt gacagtcggg atgttgtggt 2326681 ccattgtcgc aaatgtgttt tggggtcttc tgacctttct tcccttttgt ctcaagcctt 2326741 caaatgcctg aggagacgtc acctcatgaa tgaggtgcaa atcaatatag agaagatccg 2326801 gctttccctc accatgtttt acaatatgct gatcccaaat cttttcgatg attgttcgag 2326861 gcatcatctt ttatttcctc cctctaccta gagctaagac cgcttaacgt aagctgtcac 2326921 acattagaaa ttgtattttc actcatgatt gctgccttaa cttcctctgt aatggcctga 2326981 gtgctgctga actcttcact ccgtgccaag tctcttgttc tttttccaga agccaagact 2327041 ttgtttaccg catcttctac agctttcgct tcctcttcaa gcccgaaaga tgttctcaaa 2327101 agcattgccg ctgacaatat ggctgcgaac ggatttgcca tccctttacc ggcaatatca 2327161 ggcgcggagc catgaacagg ttcaaacaga tgaaggccag agcttgatag gctggctgac 2327221 gggagcattc cgagcgagcc tgtaagcatg gacgcttcat cgcttaaaat atcaccgaac 2327281 atattttcag tcaccacgac atcaaattga ttcggtgcat aaattagctg catggccgcg 2327341 ttatccacaa gcatgtgctc aagcttcaca tcaggaaatt cttgtgcaac gtcctcagcc 2327401 acttcacgcc acagccggct tgattcaaga acattcgctt tatctacaga ggtcactttg 2327461 ccttttctgg ctgccgccat tttgaagccc tctctgatca ctcgttcaat ttccgttcgc 2327521 ttataaaaca gtgtatctac tgcttcctgc tcaccttcag tgtttacata acgtttgctc 2327581 ggctggccga aatacaagcc gcctgtgagc tcacgaacga taacgaaatc aacattatct 2327641 atatattctt ttttcaaagg cgaagcgtca gaaaggcttt caaatacctt cacaggccgc 2327701 aaattcgcaa acaaatcaag ctgttttctg atgctgagca gccctttttc cggtctcagt 2327761 tccgaaggat tttgatccca tttcggtccg ccgacagcac caagcaatat cgcgtctgca 2327821 tttttacaag cagcaacggt ttcctccggg agggggttat gatgttcatc aatagccgcc 2327881 cctccaatca ggccatattc aaattcaaat tcatggttaa agcgttcggc aacacttttc 2327941 agtacgtctg tcgctgattc taatacttca gggccgatcc cgtctccggg caatagagca 2328001 atacgtttct tcaagttaac cgttctcctt tcttttatga tccgacagct gtgtggtttt 2328061 tcaatccgct catattcgac tggaaaacca attgacggtt tactgcgttc aaataggctt 2328121 tcgctgatgc ttctaatacg tcttgcgcta tgccccgccc tgctgattct tttccgttca 2328181 ccaaaactct tacatacacc tgggcaaatg catcttcgcc ttttctatta gactgaatgc 2328241 ggtagtctaa gagctccaca tccttatcga tgcagcgctc aagcgtattg tagattgctt 2328301 ccacgcttcc agctccagtt gcagcttcct gaataagctg tgcgttttct tgatttttca 2328361 aagatagagt agccgtaggg acctgacttg ttccgtaatg tacttgcaga gaaagaaatt 2328421 catacccaat cttgcgatct gttacttttt cttctaaaat aagagaaaca agatcctcat 2328481 cagtgatttc ttttttcttc tcagtcaact ctttgaacat cgtaaagaat ttattaatct 2328541 cttcactgtc aaattggaat cctaaagcag tcagccggtc tttaaatgcg tggcgtccgg 2328601 aatgtttacc taggacaagc gcatctgcgg ttacgccgac aagctccggt gaaataattt 2328661 cataagtcga tttttccttt aaaaagccgt cctgatggat gcctgattca tgagcaaatg 2328721 cattatctcc aacaaccgct ttgttgcgcg ggacagccat gcctgtcagt ttgcttacta 2328781 aatcacttgt tctcttaatc tcgttcagcg taatacctgt ttcgacttgg tagaaatctt 2328841 ttctggtatg gagggctacg gcaatttcct ctaatgccgc gtttccggct ctttcaccga 2328901 tcccgttcac agcgcattcg atttgatcag cgccattttc aatcgcagca agagagtttg 2328961 cgactgccat tcccaaatca tcatgacagt gggctgaaag ctttgctttg tgaatgttcg 2329021 gaacgttttc tttcatatat ttaaagatat ttccgtattc cgccggggcc aggtagccga 2329081 cagtgtccgg aagattgata acactggcgc ctgcgtcaat cactttctcg acgatttctg 2329141 ctagaaacgg cagttcagtg cggcaggcat cttcagctga ccattgcaca atcggaaaac 2329201 gttcttttgc gtatttcacc attccaactg ctctttcaat gacttgttca cgtgtcattt 2329261 tcagcttgtg cttcaaatga atgtccgatg tcgcgataaa tacatgaatt cttggttgag 2329321 cgccatcctt taacgcttcc caagcagcat caatatcacc ttttacacaa cgggccagac 2329381 cagttactga acaattttta atggttcttg cgatttcctg aacagctaaa aagtcacctc 2329441 gggacgaagc gggaaatccc gcttcaatga tgtctgcccc gagtctttcg agctgcttag 2329501 ctatggcaag tttctcctgt gtattcaagt tcactccagg ggactgttca ccatcacgaa 2329561 gcgtcgtatc gaaaaaatta attttgcgca acggagacca ccgcttcctt cttcttgcct 2329621 tgtttcacaa acggcatcat ttcacgaagc tttcttccca ctacttcgat ttgatgttcg 2329681 ttctcgcttg cattgatagc gttgaaacga ggacggttta cttggttttc gacgatccac 2329741 tcttttgcga atgtaccgtt ttggatatct tttaatactt ctttcataga ttcttttact 2329801 ttggcgtcca caacgcgagg gcctgatacg aaatctcccc actgtgctgt gtcagagatt 2329861 gaatatctca ttcctgcaag tccttcttcg tacataaggt ctacgattaa tttcagctca 2329921 tgaagacact cgaagtatgc aagttcaggc tgataacctg cttcagttaa ggtttcaaat 2329981 ccggctttga caagcgcgct taatccgccg caaagaactg cttgctcacc gaacaaatct 2330041 gtttctgttt cttctttaaa tgtcgtttct aatacgcccg ctcttgcgcc gccgattcct 2330101 ttagcataag cgagggcttt gtctcttgct tctccagtca catcttgata gattgcgaac 2330161 aatgcaggta cgccagctcc ttgctcatat gttcttctta ccaagtgtcc cgggccttta 2330221 ggggccacta agaatacatc tacatccgcc ggaggaacaa tttgatggaa atgcacgtta 2330281 aatccatgag cgaatactaa tgattttcct gctgtcaatt catctttgat ttcagcttcg 2330341 tatacttttt gctgctgctc atccggaagc agaaccatga tgatttcggc ttgggctgcc 2330401 gcttctttta ctgaaaatac tttatgtccg tcttcttggg cttgagtgaa agattttcct 2330461 tgtctaacac cgacgatcac gtctactccg ctttctttaa ggttcagggc atgtgcgtgg 2330521 ccttgcgaac cgtacccgat aaccgctact gtttttccag ccaatacgtt ctctttgata 2330581 tcaccgttat aatatacttt taccatttca atctctccct tgttatgttt tatacaatag 2330641 atattgtttt attggatgac gccttttgct gggttcccct cgcaaaagcc gttgtacctg 2330701 ttctcgcgat ttctttaatg ccataaggtt ttaataactc aataagcgct tcaattttgt 2330761 tagattcacc tgtcacctga acaacgatgc tgtctctgct gacatcaacg acagaggctc 2330821 taaacggttc tatgattcca ttaatctctg ttcttgttga aggtgcggag acaaccttga 2330881 ttaaggccag ctccctctgg acaatcgatt gatttgtgat gtctgtgact ttcagcacat 2330941 caatctgttt gttgagctgt ttcgttaact gttcaacatc attttcacct tcaacatgaa 2331001 cgacgaaggt gattctggaa acgccggctg tttctgtgtg tccaactgta atgctttcaa 2331061 tgttgtaatg cctttttgtg aatagaccgg tgatccggtt taacaccccg gagcggttca 2331121 ccacagtcaa tgtgataatt cttttcaagg tttcaccccc accatttcat gcagcccttt 2331181 ccccggagcc accatcggga atactttttc ttcgctggca acccgcacgt caatgacaac 2331241 aggttctctt gatgttaatg cctcttccag cttttccttt gcttccgctt ctgatgaaat 2331301 tctgatgcct ttaatgccgt atgcttcgga caatttgacg aagtcaggct gagaagcgaa 2331361 tttagattct gaataacgtt cttcatagaa aatttcctgc cactgtctga ccattccgag 2331421 acaagcgtta tttaaaatca ctaccttgac cggaagattt aattcgcgaa taacatcgag 2331481 ttcttgaagc gtcatttgga atccgccgtc tccgacaacc gcgacaacag tagcatcttt 2331541 ttcggccagc tgtgcgccga tcgccgccgg aagaccgaat cccatcgttc caagtccgcc 2331601 tgacgtgacc catttatctg ctttttggaa cggataaaat tgcgctgacc acatttgatg 2331661 ctggcctaca tccgttgcga caatggcctc tccttttgta aattgatgaa tatattcaat 2331721 caatttctga ggtttaaaac cttcttcttc attatctaca taccagagcg gatactcttc 2331781 tttccattct gcgagctgtt ttttccattc gcttgaatcg ctttgtttgc cgtcttgttt 2331841 gatcagctcc tgcaggacaa ttttgctgtc tccgactaca ggaatctgtg ttttcatgat 2331901 ttttccgatt tcagctggat caatatcgat gtgggctatc tttgcgtttc tggcaaagtg 2331961 tttcaggttt cctgtgacac ggtcatcaaa acgggcgccg atactgatta atagatcaca 2332021 ttcatgaagg gccatattgg ctgtataagt accgtgcatt cccgccatcc ctaggaaaag 2332081 cggatggtca gccgggaagc ctccgagccc caaaagggtg tgtgccacag ggatttgctg 2332141 ctgttcagca taatttttta attcttctga cgcttttccg tgcagtacgc ccgcacccgc 2332201 caggatcacc ggttttttcg cactgctcac ggcttccaca agcttgcgga tctgcaaata 2332261 attcggctct gttgtcggct ggtatcccgg gagattcatc tcatgatcgt agctgaattc 2332321 tccttcaatt gttgctacat ctttcggaat atcaatcaat acaggtccgg gtcttccagt 2332381 tgttgcaata tggaacgctt ctttaatgat gcgcggcaga tcttccggct ggcgaacctg 2332441 gtagctgtgt tttgttactg gcatcgtaat ccctaaaatg tctgcttcct gaaatgcatc 2332501 gctcccgatt acagaggttg ctacctgccc tgtaaagacg actaacggca atgaatcaat 2332561 catggcatca gcaaggcctg taacaaggtt tgtcgctccc ggccctgacg tggcaatgac 2332621 gacacccggt tttccggaga cccttgcgta tccctccgct gcatgaattg ctccttgttc 2332681 gtgacgggga aggatatgta ccaaccctga attgtatagc ttatcgtaaa tcggaagcac 2332741 agccccgccc ggataaccga agatcatttc tactttctct ttttttaatg attcaatcag 2332801 cattaatgct ccgctcatcg tctgtgtaca ttcggcagat gctgaatcca cctgtacatt 2332861 agtccccatt ttagttcctc cttttggatt ttcatccttt aaagatcatc ttttcattag 2332921 ctagatagct gattattcaa taaaaaaagc ccttccgccc acaatcagcc gcgcagtaac 2332981 tgcgatagct aaaaggggcg aaaaggcttt tctttccgcg gtaccaccct tgtttacggc 2333041 ctgttaatcg gccgtctcat ggatatttct atccgcttta gtaacgagtg aatcaagttc 2333101 acccggccaa gtcctactgt catttcagac tggcactctg aggcgagttc accttgtaaa 2333161 gcttcgccgg ttctcagcta acccggttct ctgtggaaaa ctttatcaag gctacttatc 2333221 ctcatctgcg cttttcatat tcagccttcg gaacggcttt ccagctgttc aagaaggtcg 2333281 tttgtttttc atttttttag aatcatactg cgatgatttt cgcttgtgaa gcttgcattt 2333341 atcttttgtt gaactcatat tacgccgctt tggacgcagt gtcaacagca ttttttaaaa 2333401 ttattagaca attttgatta atcaatctat attgtatacg ctttcattat tggtacaaaa 2333461 ggaattgcaa atgttaaaag tttttataat ttttttatta atctatcaag aatacaccag 2333521 aattatttaa ttttatataa acatggaaga ttttataaca cgatatggtt cgtatatgga 2333581 ttgagtctga cagatcatct tgcaatccat ttcaatttcg gataggcact tctcttgttc 2333641 cctcggcata cattaatgat atcttgcaaa gaaaaggtga tacgatgaat aaatcatttg 2333701 cagacatgca aggatttcct gcgggctttc caagcttccc caactttccg cagcagtact 2333761 atcctgctgt ccctcccttt taccagcaaa gccagcagcc atttggaggc tacggatacg 2333821 gacagccgtt cagtcaggca tacagcccgt taaccactcc ctctggaatg tactcctcat 2333881 tcccatacgc ttcaggattt tacggacagc aattttcagg tgcaggcttt agcggccatg 2333941 gcggcagctt aagtgctcca gcgatacatg ccggcggatt cagcggggcg ccaggcgtac 2334001 acggaggctt tagatattaa agaataccac aagggccgaa catctattgc ggtcctttta 2334061 ttgttttaaa acgacttcac aagtacagtc acattttctg tctttatatt tggaaacagg 2334121 atggaatatg attaagatga attgaacgat attctgcaca atccgtaagt tttcgaggag 2334181 gaataaaatt gcatataaaa atagacgatt taactggacg tcaggtggtt tcactggtga 2334241 atgagcattt acatagcatg acgcttatgt ccccgccaga aagcattcat gccttaggtc 2334301 tagaaaaact aagagggcct gaaataacat tttggagcgc atgggaaggt gatgaactag 2334361 ctggctgcgg agcgctaaaa gaactggaca cccggcatgg agaaatcaaa tcaatgcgaa 2334421 catctgcatc acatttaaga aaaggcgttg ccaaacaagt tctccagcac atcattgaag 2334481 aagccgagaa gcgaggctat gagcggttaa gcttagaaac gggttcaatg gcttcatttg 2334541 agccggcaag aaaattgtat gaaagcttcg gtttccagta ttgtgaaccg tttgcagact 2334601 acggtgaaga tccaaacagt gtgtttatga cgaagaaatt gtgagacggc tttataagga 2334661 tagataagtg caggggaagg tctgtcttat ctatcttttt ttatattcac acatttttca 2334721 cctttatgat acacgccaat gttttcaatt ttgtttaatt caaagaacag cgggaattac 2334781 aaacgacatg aacgatatca tgcaaattca taaaggagga gattgatatg aaaagcatag 2334841 ttggtgtata tgaaactccg caggaaacca tcgcagcgat tgaaggctta cttacaaaag 2334901 gctatgattc tgatgacatt tctgttgtga caagccggcg agatacagat tatttggagt 2334961 cacgtacagg aacagaagtc aatcaagcta tcgatgcaca tcaggacgaa tctgaatctt 2335021 ttttcgataa actgaaagat tatttcacaa tggatgatac tgctacacac agcaaagcat 2335081 tatccgactt ggatattaaa actgatgaaa tagacaagta tcaagaagat ttggatgacg 2335141 gaaaacttct ggtagccgtc gatacagatg cagatgtaat tgctcctatt gataacggca 2335201 atgccctttc aggcggcttt tcaagcacaa atgaattgga ttatacaacg aaagaagaaa 2335261 aaacgatgcc gctccgggaa gaacagctga aggtcgataa ggaagacgtt caaaccggcg 2335321 aagtagaaat aggaaaagaa gtgaaaacag aaaaaagaga tatggacatt ccggtgagac 2335381 atgatgaaat ttatgtcgaa cgccgtccag tggatgaaaa taaaacggac gctgctcccg 2335441 tcaacgattc ggaagagatc agagttccaa tcgttgagga aaagctggaa gtgactaaaa 2335501 aaccggttgt cactgatgaa gtggttgtcg gcaaacgcac tgttgaagaa aatgaacata 2335561 tttctgaaac tgtgaaaaaa gaagaacctc gtctgaataa agaaggaaaa gttgacggct 2335621 tggatgatga tccgttaaat aacaaatgaa aatcatagac cgacaacaaa aaacctcaaa 2335681 tcctaaatgg atttgaggtt tttcttttgg tacgtcccag gagagattcg aactcccgac 2335741 cgacggctta gaaggccgtt gctctatcca gctgagctac tgggacacgt tttgtttttt 2335801 tgtttttcgc tttaactatc agcgacaaga tttattatat atgggatgca ataataagtc 2335861 aacggttttt tagaattttt ttcatgagga agaaaatttt cttcctcatg acattttcat 2335921 agtgtgactc gattttgcag atcctcaatt tcattgcctg cttggtcgta aaaacggact 2335981 gtcgcagcat cattttctaa tgtcagtata gcatagcttt ctgtcctgcg caccctcgga 2336041 agccggatgc tgcctgggtt aatcatcagt tttccgcgca gcacttcgct tcccgcgatg 2336101 tgcgaatgcc cgaagcagat aacatccgcc ccgagctcct ctgcacgata gtatacgttt 2336161 aacaaggtct gttttatacc gtgaaggtgg ccgtgtgtga ctagtatttt tcttgagccg 2336221 gcagtcagaa gaagctcgtc cttaaaatcg ccggcaaaat cgcaattgcc ttttacaacc 2336281 gcataaggct ccaatgcagg atgcctcgtc tcaagctcag agtccccgca atgaatcatg 2336341 agatcaactt ctgcctcatg ccgtttcgca atggtttgga gttcttcttc aagcccatgg 2336401 ctgtcactga taatcagcac gttcatgtac aagcttcctc cttatgcctc caaaagctta 2336461 gacagctttt taagcgcgtc agccctatgg ctgattttat ttttttcatc acttgtcagt 2336521 tcagccatcg tcttatcttt atctttcacg ataaaaattg ggtcatagcc aaagccatat 2336581 tctcctctcg gttcttcagc aatataccct tcaacatggc cttcgactgt ttttgtttcc 2336641 tctccgggaa tactcacggc cagtgcgcag cggaaacggg cggtgcgctg ttctttttcg 2336701 atacctttca gctcgctgag cactttttcg atatttgcct ggtcgtcttt ctgttcccct 2336761 gcatagcggg ctgaataaac cccgggtctg ccgccaagat tatcgatgga tagtccggag 2336821 tcatccgcaa tcaccatttt gttcactgct ttggcaacag cttccgcttt cataatggca 2336881 ttttcttcaa atgtatggcc tgtttcttca atttcctctg tgaatccaat ttcagctaaa 2336941 gatttgacat catagcctct tggctcaaga atttctttga attccttcac ttttcccgga 2337001 ttatgtgttg caataattgc ttctttcatg atgatcaagc ctttctgtct ttatttcagt 2337061 tctggcagag aatcacccag cacttctttt tgcttgtcaa tcagctcttg gattcctttt 2337121 tccgcaagac ccagaagacc gttcagatcc tctctagaaa aagttgcctc ttccccggtt 2337181 ccctgcaatt ccacaaaacg gccgctgcct gtcatgatga cattcatgtc aacttcagca 2337241 gaggaatctt cttcataatt taaatctaac aaaattccct gttccttatc aattccaaca 2337301 gagattgcag caagaaaatc agtgatcgga tttgtcttga ttgttcctgc tttgatcagc 2337361 ttgccaatcg caatcgccat agcaagaaat gcgcctgtaa tggaagctgt tctagttcct 2337421 ccatcagctt gaatgacatc acagtcaatc caaatcgtcc gttcaccgag cttttccaga 2337481 tctacaacag ctcgaagcgc gcggccgatc aggcgttgga tctccattgt tctgccggaa 2337541 attttcccct tagaagattc tctgattgtt ctttggtttg ttgcccgcgg cagcatgctg 2337601 tactctgctg taatccagcc tttccctccg ccccgcaaaa acggcggtac gcggtcctca 2337661 acagacgcgt tgcagattac ctttgtattt cccgctgtta ttagaacaga accttccgga 2337721 tggctgataa aatccaaatc gaatgtgatt ggacgcagct catcgtgttg tcttccgtca 2337781 tgtctcatgt tttacctccg attgtatgta cataaaccat ttttgtcccg gaattgaata 2337841 aagaaagagg cagccggaac gctaacctct ttcttcctag tatatcaaaa atcccaattt 2337901 aaaaactacc cgtattcact tgagatggtc tggagaccgg ttctgtgagc ttttcgcctt 2337961 tttcatttac cagctctgat tttccgttca ctttaacaga gacgcttttt acatccggct 2338021 gctccgttaa cgtcagcaca atgctgttca gcacttctga agaaatcatt ttcgtcttct 2338081 catcggcgct gccgaatata gattgattga aatccaacgt cacgcgcccg tctttgattt 2338141 tcggtttgct gaccagcttt acatcttcac tgaagtctgt taacagcccg ctcaccttgc 2338201 tcggcccttt agccaattca ttaatggctg ctgtgatgtc gtctttttcc gaattgtcga 2338261 ttcgtttggt caccggcacg tagtattcac tgtcttcatt ttccgccaaa tagtagactg 2338321 tcagcggatg ggtagcagtg agatcattta caccggctgt ttccaaatta atgccgtctt 2338381 tgcggcttaa atcatctgag atcggcgtcc ctcctacagg catctccttc agttcatgcc 2338441 cgtttattct cagcttcact ttatctatcg aactaaattg cgtcagcgtc cacgtcacag 2338501 attgaacgat tttctgttcg tcttctttct tataattttt gaactcatta gagaaatcag 2338561 ctatcgccgt tccatctttt ttgatgtcaa cgttaacggt ggtgtcagcc ggcaatacag 2338621 ctctgaagcc attcggaaga atttcagaca caggcccgcc ctgtacgagg tattcaagcg 2338681 cctgcttagc cgtgctctca cttttaggaa gaggcagcgt ttgcgcaaca acatacccgt 2338741 ttttatcaat gagataaagc tccctcataa cagtagatga ggcttgatcc gcttttgcgg 2338801 tatcgctttt ttcactttct gtttttttgg ctgctgttgt atttgaattg gcacccgctt 2338861 catcgttcac gaatgtaacg tcttgaggcg gatcaatttc ctcggctgcc ttatcagatt 2338921 gaaacaaacc gcatccggat aaaagcaagg cagaggtgag acaagtggca ccaatgactg 2338981 caggtccttt tttcagcata cttttccctc ctaaggatgt ttgtactatt atgtatacga 2339041 gcctctttag gaaatagacc gaagaattcc ggcaaaacag aaaaaaaccc gcaacatacc 2339101 gttgcgggga aaactatctt ttaatcggtt cttgcagtga gatacattcc acatgcccga 2339161 cttcatggcc aaaccaatcg tctgcgattt ttgcaaactg atcacgcgcc cctgttgtca 2339221 ggaactgatg atccggggca atcggagact ggttcagcag ccctttataa gagagaattg 2339281 tgctgacttc ccgggctgtt tcatcgccgg acgaaataat gtttacgtgc tctcccatat 2339341 atctttgaat ggcttctttt aaaatagggt aatgggtgca gcctaaaatc agcgaatcaa 2339401 ttgatgtgtc ttttaacgga tacagcgagg ttttaacaat ctcgtctgct gttttgtcga 2339461 gaaacttccc gctttccaca aaaggcacaa gcagcgggca ggcaaggttt tcaaccttca 2339521 aatcagggtt taatgccaaa agcgcttctt cgtatgcatt gctcttaatc gtattctctg 2339581 tgccgatgac accgatatgc tgattatccg tcacttttat cgctgctctc gcaccaggct 2339641 ggatgactcc gaccaccggt ataccgacgc tgcgctggat gtcatccaaa gcgatcgctg 2339701 ttgctgtatt acaggcgatc acgagcattt tgatgtggtg gttttcgagt aaataattcg 2339761 tcagctccca cgtatattga agcacctctt cttcagggcg cggcccgtaa ggacaccgtt 2339821 tcgtatcccc gacgtagata atattttctt taggtagctg tctcatgatt tccttcgcaa 2339881 cggttaaacc gccaaccccg gaatcaatga ctcctattgg ttgttccaac aaaatcgcct 2339941 cattttctct tcatttcatg ctgcagtttc atcaaagatt tttcgaagat ggctatttct 2340001 tcatctgtaa acgattcgaa catatcacgc agatattcct gtctttttgt aatgacctct 2340061 tggataatcc gttctccttc aggcagcaga tgtatcctga caacacgtct gtccgccggg 2340121 tccttgaccc gctcaacaag ctcatttttt tgcatgcggt cgattaagtc cgttgtcgtg 2340181 ctgcatgcca gatacatttt gcccgataat tcaccgattg tcatatctcc taattcataa 2340241 agccattgca agccgacaaa ttgcggcggc gtaatcgcat attggttaag gatttctcgt 2340301 cctttttgct taatgatcgc ggcaatgtgg cggagtgact tttcaatatc cgcaacatgc 2340361 tccaaaggtt ttgatgtcat ttgtccatcc ctcactcaag gatctcttac gcacaaaagc 2340421 gttccgtgtc tattttcctt cttttttgaa gaaaatgcaa gactcgcagg agagaaatag 2340481 aggactttag tcaaacaaca tcaagaaata aaatttaatt tatgacttgc ctacgttttg 2340541 cacagcattc caaatatggt ttcgaatgtt ccaaacaaac agcaataacc ggctccttcc 2340601 aaaagaagga ataccggcaa ggattaaagc tctagctcac ccattctaag aagctcaaca 2340661 acggcttgcg aacgcccttt cacacccaat ttctgcatgg catttgaaat atggtttcga 2340721 acggttttct cactgataaa tagctcgctt gcaatctcct ttgttgtctt atcttgaacg 2340781 agcaattcga acacttctct ttctcttttc gttagcagcg gcttcgattg aaattctttc 2340841 tccttcaagt attgtaaccc tccttgctaa ggtgagagcg aatcagaaac gaatgggttt 2340901 tgatatagtc gagatatcat atgtaagaag ggcgcaggag gtgacgttta caagataatt 2340961 agtttatcgt gtatgaagaa gcgtttcttt ctcctcatcc gtccagctga cagccttgcc 2341021 gctttccttt gagacttgaa ccatcacgac tgccccggtg aagcagggtt cgccttcgag 2341081 gttctctccg agatagtgca aggtaagaga tgaactgccg actgcgcttg ttttcacata 2341141 gatgcgcaac tcttcataag gcatgacttg gcgcaaataa tcgcattgct ggcttgccac 2341201 gactgtcatg gtctgtttgt tttcactcat catattcagc tttttaaaat aagaaatccg 2341261 cacctcctca aaatatataa aaggggttac attattcata tgcccaaaca tgtctgtctc 2341321 ggaaaatctt acggatacct tattgaaaaa agaaaaggat gttttccatt cttgaaacgg 2341381 catatcaata taagcgggaa gcttcatctt ttttcatctc cttattgttt aaaaaaacct 2341441 ctcccatgcg gaagaggttt tttcttctta tactctgtcg cttccgaaga aattgcggaa 2341501 cgcttgtaag tttgtatctc tattcaaggc tgcaatcgaa gtggtaagcg gaatcccctt 2341561 cggacaggat tgaacacagt tttgcgagtt gccgcaatct gcaaggccgc cttcatccat 2341621 taatgcttct aatcgttcag atttattcat ggcgcctgtc ggatgcgcgt taaacaggcg 2341681 gacttgcgac atcggtgcag gccccatgaa cttcgatttg ctgttcacat tcgggcaagc 2341741 ttcgaggcag acgccgcatg tcatgcattt tgataattca tatgcccatt gacgacgttt 2341801 ttccggcatt ctcggccccg gtcctaaatc gtacgtaccg tcaatcggta tccacgcttt 2341861 tacttttttc aatgaatcaa acattctgct gcgatcaacc tgcaaatcac gaacgactgg 2341921 gaatgttttc attggtttta aacggattgg ctgttcaagc tggtcaataa gcgccgtaca 2341981 agactggcgg ggttttccgt ttataaccat tgaacatgcg ccgcatactt cctcaagaca 2342041 gttcatatcc catgtgacag gggttgtctt ctcacctttg acattaaccg gattccggcg 2342101 gatttccatc agagcggaaa tgacgttcag attcgggcgg tatggaatct caaattcttc 2342161 atcataaggc gtgctgtcag ctgtatcttg acgtgtgata ataaatcgta tggttttttg 2342221 ttcactcatg attatttcgc caccttcttc ttcgagtaat cccgtttccg aggcgttatc 2342281 agtgatacat cgacatcctg atactcaaat tccggcgctt catacgggct tacatgttta 2342341 gccattgttg ttttgagcca ttcatcatca ttacgttcag gataatccgg tttataatgg 2342401 gcgccccggc tttcattacg gttgtatgcg ccaagggtaa tcaccctcgc aagctgaagc 2342461 atgttcgaga actggcgtgt gaacatcgct ccctggttgc tccattttgt cgtgtcattg 2342521 atgttgatct ttttgaagcg ctccattaac tcctgaattt tgtcatccgt tttcaaaagc 2342581 ttgtcattat ggcggacaac cgttacgttc gccgtcatcc actcaccgag ctctttgtga 2342641 agaacatagg cattttcggt tccgtccata ctcataatat cagcccattt ttcttcttct 2342701 ttcttaacgt gagcgtcgaa taaagatgaa gacatgtctt ccgctgaaga ttctaagccg 2342761 tttacatatt tcaccgcatt cggaccggcc accatgcctc cgtaaatcgc agacagcagg 2342821 gagttcgctc ccaagcggtt gccgccgtgc atagaataat cacattcccc agccgcaaac 2342881 agtccaggga tatttgtcat ttgatcgtaa tccacccata aaccgcccat agaataatgg 2342941 accgccggga agattttcat tggaagctta cgcgggtcgt ctcccatgaa tttctcataa 2343001 atctcaatga tgccgccaag cttaatatca agctctttcg gatctttatg agacagatcg 2343061 agatatacca tgttttcacc gttaataccg agcttctggt tcacacacac atcaaatatt 2343121 tcgcgtgtcg caatatcacg cggcaccagg tttccgtatg ccggatattt ttcctccagg 2343181 aaataccatg gtttgccgtc tttatatgtc cacacgcgcc cgccttcacc acgcgctgat 2343241 tcactcatca gtcttagttt gtcatcgccc ggtatggctg tcgggtggat ttgaatgaat 2343301 tctccgtttg cataatacgc tccctgctga taaacgattg acgcagcaga tcctgtatta 2343361 atcatggagt tcgttgattt tccaaagatg attcccggtc cgcccgtcgc cataatgaca 2343421 gcgtctgaac ggaaggattc aatttgcatg tttgtcaggt tttgtgcaac aattccgcgg 2343481 caggttctgt catcatctaa aacagcgcca aggaattccc agccttcgta ttttgtgacc 2343541 agacccgcaa cttcgtatct gcgcacttgc tcgtccagtg cgtaaagcag ctgctgtccc 2343601 gtcgtcgcac cagcataagc agttctgtgg tgctgtgtac ccccgaatcg gcggaaatca 2343661 agcaggcctt caggcgtccg gttaaacatg acgcccatcc ggtctaataa gtggatgatc 2343721 gaaggcgccg cttcacacat cgccttgacc ggcggctggt tggcaagaaa gtctcccccg 2343781 tataccgtgt catcaaaatg ttcccacgga gagtcacctt ccccttttgt attgaccgct 2343841 ccgtttatgc cgccttgcgc acaaactgaa tgagaacgtt tgacaggaac gatggaaaac 2343901 aatttaaccg ccattcctga ttccgctgct ttaattgtcg ccatgaggcc ggcaagaccc 2343961 ccgccgacta cgataatgct tgattgactc atgatagccc ctctccctct agtaatctag 2344021 tactcttaaa caaatgcaaa aatcgctttt aagcctacgt atgacagtgc aacaaaaata 2344081 atcagcgtaa cgtatgtcga aattctttga gaacgaggcg ttaccgtgat gccccatgta 2344141 acagcgaaag accataaacc gttcgagaag tggaaaattg ttgataaaac accgacaatg 2344201 taaaaaccaa gcatagccgg agagctcaaa atattcgcca tcatgtcgaa attgacctca 2344261 gcacccattt gtgcggcaat gcgggtttcc cacacgtgcc agctgacgaa aatgagggtg 2344321 atgataccgg ttacacgctg caggacgaat agccagtttc tcatgtagct gtattgaccg 2344381 gcgttatttt tcgcagtaaa cgctatgtac acaccataaa ctgcatgata aattaatggt 2344441 aagaagataa taaaaatttc caaggcatac ctgaaaggca ggctatccat aaaatgagca 2344501 gcgctattga atgcttcagc gccccttgcg gcaaactggt tgacgactaa atgctgaata 2344561 agaaagatgc cgaccggtat gacgccaagc aaggaatgca atcttcgaaa ataaaactct 2344621 ctgttcccag acattacttt accccctgtt tgataagtgc gaaatgtgct aaatctcttc 2344681 ccccacttct ttcaattgta agcactttat taagatttat tgacaatttc attttactcc 2344741 tccctcaaaa gggcgtcaag aaaacgcgta cataaattat aattttccga attgattagt 2344801 tgattgaaaa attttatttt atcaatatat atttcttgct taatttttca taagaattac 2344861 aggatcattc tgtaatcctc ccccctgttt gagctataat atacgcagga gagaggggag 2344921 acagatatga agtctaaatt tgaagcatct attgacaacc taaaagaaat tgaaatgaac 2344981 gcttatgcct acgaactaat acgagagatc gttctcccag atatgcttgg ccaagattac 2345041 tcttccatga tgtattgggc aggaaaacat ctcgcccgta agtttcctct tgaatcatgg 2345101 gaggaatttc cggccttctt tgaagaagcg ggctggggaa ccctcaccaa cgtaagcgct 2345161 aaaaaacagg agcttgaatt tgaacttgaa gggccgatca tttccaaccg gcttaagcat 2345221 cagaaagaac cttgctttca gctggaggct ggttttatcg ctgaacaaat tcaattgatg 2345281 aatgatcaga ttgccgaatc atatgaacaa gtgaaaaaga gagccgataa agtggttctg 2345341 actgtgaaat gggatatgaa agacccagtg taatcaaaaa ggcggtgact gcatagtccc 2345401 gcctttttga ttgtcattac acagctgaag ggtgttttga aagctcaaat gcatcgtgaa 2345461 gcgactcgac tgctttcacc atgtcatttt cgcttacgac tgttgacact ttgatttcag 2345521 atgtgctgac cattttgatt aaaatgtttt tttgcgccag tacagcaaac atttcagccg 2345581 ctacaccggg atttgagacc atgccggatc caacaataga tactttagcc aatttgcttt 2345641 ctgtctcgat tttctcaaat tccagcgcgt ctttatactc ttcaagcacc gcaacggttt 2345701 ggtctgcatc ttctgttttg acagagaagg aaattccagt cttgtcctcg gcctgcgttt 2345761 ggataatgat atccacgttt atgtttcttt tggcaagtgt tgtaaaaata gtagacaaag 2345821 ttgtcaggcc gctagtcagc ccgtaaatgg ttactcttgt gatttgatct tcaaatgcaa 2345881 tgcctctgac aattaaattc tgttccatgg atgattcctc ctcaattaat gttcccgctt 2345941 cggtttctgt acttgaacgc acttctaacg gcacttggta atttttcgcg aactcaactg 2346001 ctctcggatg aagaacaccg gcgcctaaat tggcaagctc aagcatttca tcgtatgaga 2346061 tgccctcaag ttttctcgct gatttcacat agcgcggatc ggttgtaaac acgcctggca 2346121 cgtctgtgta tatgtcacat ttatcagctt ttaaagcggc agccaaagca actgctgttg 2346181 tatctgaacc gccccggccc aatgtcgtaa tttcacaatc ctctgtcatg ccttggaatc 2346241 ctgcaacaat gacaattttt cctttttcaa gctggtctgc taaaaccgaa gtgtcgatat 2346301 ctgtaattct ggcgtttccg tgaatggcct ccgtacggat tcccgcctgc cagccagtat 2346361 aagacacagc gtcatagcct ttttcctgca atgccattga aaggagtgaa atcgtgacct 2346421 gctcgcctgt cgccagcagc atatccattt cgcgtttgct cggctggtca gaaatagctt 2346481 ttgcaaggct gaccaattcg tcagtggatt ttcccattgc tgaaacgacg acaacgactt 2346541 gatggccttt ctgtttttct gcaattgcgc ggtttgccgc attttgaatt ttttcgactg 2346601 agccgacgga agtgcctccg aatttttgta caataagacc catgtattac caccctttac 2346661 attttggttc gtgcgggtga ggagaaagag cgctttgtcc acaataaaaa aagcaatgag 2346721 aggaatactc tcattgctta tcaattaatc atcataaatg attatgaaca acgagatagc 2346781 cctccaagaa aatgatttct tgacagcctt acatttattc aatgcacggc cagcaaataa 2346841 taccgatggg gttttatttg cttcggcgac gctccccttt cagccttttt cacagaatcc 2346901 atctttctcc aaaggcatac tcttgaagtt cgcacctcta tcttcaccat ataacacgat 2346961 ctaactatga aattagttca cattttatca gatcttattt aaaaggacaa cattattttt 2347021 gcaatttgtc gtaaaggagc tgagccgccg ctgcgggaac accggctttt ttgatgtcct 2347081 caaggcttgc ttccttcatt tttttaacgg aaccgaaatg ctttaacagc attttctttc 2347141 ttttctctcc gatacccggg atgtcgtcca aaacggattg aaacgcgctt tttccccgga 2347201 tttgcctgtg aaaactgatt gcaaaacggt gcacctcgtc ctgaatgcgc tgcaggaggt 2347261 aaaattcctg gctgtttcgt tccagatacg ccacctccag cggatcaccg atcagtaaat 2347321 ttgaggttct gtgtttttca tctttcgcta aaccggcgat cgggatatcc aagccgagtt 2347381 cattttcaat gacatccctt gctgcgttga tctgcccttt tcctccgtca atgataatca 2347441 gatcgggcag cggcagattc tcacgaagca ctctcgtata gcgtcttctg acaacctctc 2347501 tcatagaacc gtaatcatcc ggccctgtaa cagttttgat tttatatttg cggtattcct 2347561 ttttgtatgg tttgccatcg ataaacacaa tcatcgcgga aaccgggttt gtcccctgta 2347621 tatttgagtt atcaaacgct tcaattctgt gcggcgtata aatatttaat gcctcaccta 2347681 gtttctgcac tgccccgatt gaacgctcct cgtcccgttc gattaaagag aatttttctt 2347741 tcaatgcgat tttcgcattt ttatgggcaa gcatgagcag ttcttttttc gggccttttt 2347801 tcggctggtg aacgtttgtt tccagtagct gctcgatcat agattgatct atgctgtccg 2347861 gaactaaaat ctccttcgga aggaagtggt tgttttttga atagaactgc ccgatgaacg 2347921 tgaggaactc ttcatctgct tcctgataaa gcgggaacat gctgacatcg cgttcaatga 2347981 gctttccttg gcggatgaaa aagacctgca cgcacatcca gcccttatcg tacgcgtacg 2348041 cgaacacatc acggtcgact agatcgttca tcgtcatttt ttgtttttcc atcgttgatt 2348101 caatatgggc aatttggtca cgaagctctt ttgctcgttc aaactcaaga ttctcagcag 2348161 cttcatgcat tttctcttca agctcttttt tgacctcatt atagccgccc cttaagaaac 2348221 gtgtaatgct ttcaaccagc tctctgttcg tctcttcgga aatatccttt acacacggag 2348281 caaggcattg gcccagatga tagtaaaggc acactctgtc cgggagcttg gagcattttc 2348341 tgagaggata cagacggtcg agcagttttt ttgtttccct tgctgcctgt acattcggat 2348401 acggcccgaa atagcgccct ttgtcttttt tgacattgcg ggtgacaatc agccttgggt 2348461 ggcgttcatg ggtgagtttt atgaaaggat aggttttgtc gtctttgagc atgacgttgt 2348521 atttcggatc atgctttttg atcagattca tttctaaaat aagcgcttca agattggagg 2348581 acgtcacaat atattcaaaa tcctcgattt ccgtcacaag cctttgggtt ttcgcgtcgt 2348641 gagaaccggt gaagtaggag cgcactctgt ttttcagcac ttttgctttc cctacgtaga 2348701 tcacagtctg ctgccggtcc ttcatgagat aacaacccgg ttgatcagga aggagggcga 2348761 gtttttcttt cagttgtttg ttcatatgtt acccttcctt atgtttaatc ctttatttcc 2348821 agtttaacac gaacgtttgt ttttctctat ggttcacaat tggcgaataa aaaaagcgat 2348881 ccctcaatcg gaatcgctct ggcatgtaag cagcggaaaa ttaaagatgt ttgtttacaa 2348941 gctcttgaag cgcttctttt ggtttgaagc cgactgaagt ttcaactact tcgccgtctt 2349001 ttaacacaag aagagtcggg atgctcataa cgccgtattt tccggcagtt tcttggtttt 2349061 cgtctacatc gatttttacg attttcagtt tgtctcccat ttcttgatcc aattcttcaa 2349121 gaacaggtgc aatcatttta caaggtccgc accaaggagc ccagaagtct gccagtacga 2349181 cgccttcgct tgtttcagct gagaaagatt gatcagttgc ttttacgata gccattattg 2349241 aattcctcca atgtgaaatg atgattttta gtatagcatc tcccattcgt tcacgctatt 2349301 ttaatgctta caaattattt tttcctgatc acagccggtt tactcatttt tatatggttg 2349361 aatgggatat gctctttttt taaaacacaa atctgataat ggccccgatc actacaattg 2349421 ccccaataat cattaaaatg gtacgaagca taagatcaca tctcctcttc actgtcatgt 2349481 actttaccat gccctgccgg agctgtttta aaacctgaaa aagagcgccg gcatgaagct 2349541 ccggcgctct tgcgcgatta agaatcagca cgcagcgtaa gtaagacgac tgacattggc 2349601 gggagtttta ctttcagttt gtttttgctg agcgtgtatt gtctgaagga ttccggtttg 2349661 acatgatgag gatcgtcaaa cgtgttatgc gcattcattt tttctgccgt aagaatgact 2349721 ccggaatggt ccgctgcctt gtgtaggccc ctcagctcga tttccgcctc tgctttgttt 2349781 tggtgatcga tgttgcaaat tgtgatattg atatcgcctt cagcttgttt cgacgctgaa 2349841 atgctgattt gcggaagcgt ttcaccgttc cattcatagt cggcagacat tgtctctgtg 2349901 gctaaaagag aagcgtcctg gtgcacctta aacatattga atacatggta cgtcggtgtc 2349961 aaaagcatcc gctctccctc agtcaaaatc atcgcttgaa gaacatttac tgtttgggcg 2350021 atgttggcca tttgcacccg gcggcaatgc tgatggaaaa tgtggaaatg agaagccgcc 2350081 accagtgcat cacgaatggt gttttgctga tataagaaac cgggattcgt gcctggctcg 2350141 ggatcaaacc acgtgcccca ttcatcaata atcagcccga cccgctgctc cggatcgtac 2350201 cggtccataa tcgtgccgtg tttttgaatc aattcatcga tgtatttggc ttttttcatc 2350261 gtaataaacc attcatcttc cgtgaattct gtggctgatc ctttgccctt ccagaaatcc 2350321 cccggaatcg tgtaataatg aagactcaac ccgtccatca ggccagcggc ttttttcata 2350381 agcacgtccg tccaattaaa atcatccaca tttgcgccgc ctgcaatttt ataaatgtca 2350441 ttcccgctgt aattgcggac ataagtctga aaacgccggt acagatctgc gtagtattcg 2350501 ggatgcatgt tgccgccgca gccccagttt tcattgccca cgccgaaata tttcagcttc 2350561 caaggctctt ctcttccatt ttgctttctc cagtctgaca tcggcgtgcc ttcttcaaat 2350621 gtcatatact caatccactc cgacatttcc tgaacggttc cgcttccgac attgccgcaa 2350681 atatatggct cgcattcaag cagctcgcaa agcatcataa attcatgcgt tccgaattca 2350741 tttgattcaa ttgtaccgcc ccagtgagtg ttcagcattg tcttacggtc accgacaccg 2350801 tttgcccaat ggtattcgtc cgcaaaacac ccgcccggcc acctaaggac aggaatgtgc 2350861 agctgtttga gcgcctccag cacgtccttt cgtatcccgt tgatattggg gatgtctgag 2350921 tccgttccga cccagatccc ctcataaatc cctcttccta aatgctcagc aaaatgaccg 2350981 tatatatttt tgttaatggt tccttttgcg atatctgttt gaatcactgc ttgatgttca 2351041 gacatgcctc tgatcattcc tttcatacgg atatgaaaag caccacagtc aaatatgtga 2351101 tctgtcgttt gcctgaggag tcagcatgaa tgtaagcgct tttaaagtaa ccatattata 2351161 tatgttcgta catgtcaacg acattttcta ttgtttttat atttgtacgt atgtatttat 2351221 aaatatgaaa aaacccggac ttttaaagtc cgggatttcc tttatgagtg tatattcagc 2351281 tgtttgaatt cctcagttaa taacgggaca acttcaaata aatcaccgac gatgccgtaa 2351341 tccgctattt taaagatatc ggcttcgggg tctttattga tggcgacgat caccttgctg 2351401 tttgacatgc cggccaaatg ctggatggcg ccggaaatgc cgcatgcaat gtacaaatcc 2351461 ggagtaacga ctttcccggt ctgcccgatt tggagagcat aatcgcaata atcagcgtca 2351521 catgccccgc gagaagcccc gactgcggcc cctagcacct ctgcaagctc ctgcagcggc 2351581 tgaaatcctt ccttgctttt gactcctcgg ccgcccgcaa cgataatttt cgcttcggag 2351641 agatcaacac cgtccgccgt ttttttcacg acctcttgga taacagtgcg gaggtcagta 2351701 agagaaacat caatgctttc gatgctcccc gatctgctgg tgtctttttc tgaagcttga 2351761 atgttattgg ggcgaattgt tgcaaagatc atcggatcgg ttgaaatgac gcgttcaaaa 2351821 gctttccccg agtaaatcgg ccgtgtgaac acaacattcc ctccggtaac gcttacatct 2351881 atagcatcag aaattaagcc tgtttgcaga cgggcagcaa gcttcggtga aagatccttg 2351941 cccattgccg tatgcccgaa gatgactgaa tcaggatttt cttgctcgat aacacctctc 2352001 atgacctggc tgtacccgtc tgccgtgtat gttttcagct tcgggtcctc agcggtaaga 2352061 actttatctg ctccgtaatg aataagctct tgtgcaatgc tttgtacatt ttcaccgatg 2352121 agaacaccga tgacttcccc atctcctgaa atggttcttc ctgcagctat tgcttcaaag 2352181 gtgacatttc gcaattcccc atcgcgtatt tctccaagca cgatcacttt ttttcccatt 2352241 ctaacatccc cctgtttctt tgaatgtcca agttttaaat gactttagct tcgctgcgga 2352301 gcaatgaaac aagctctttt gcctgttcag caggctcacc ttggagaagc ttcccggctt 2352361 cttttttcgg cggcagaaaa cgttcaatgg ttttcagctt tggttcagca tcctcttcgt 2352421 ccagatcaag atcatcaagt tcaagctctt caagcggctt tttcttagcc ttcataattc 2352481 ccggaagcga tggatagcgc ggctcgttta agccctgctg agctgtgaca agcaatggga 2352541 gcgtcgtttt gattttttca acatcccctt cgacgtccct ttctgcttct gcatcagtgc 2352601 cgttgatttc gagtttggtg atcgtagtga tacacggaat gtccagtagc tcggcaagcc 2352661 gaggcgccac ttgtcctgat cctccgtcaa tggcaacatt tccgccgaga atcaaatcaa 2352721 actcctgatc cttcatatag tggtataaaa cttgagaaat ggaatattgg tcgggttcat 2352781 caagatcatc ttctatgttg attaaaacag cttggtcaca acccatggca agcgccgtac 2352841 gcaattcttt ctccgcttct tcaccgccga ccgtgacagc ggtgatcgtg ccgccatgct 2352901 tttccttcag ctggatggct tcttctatcg cgtactcatc atatggatta atgatccatt 2352961 ccgctccgtc atcctgaatc tttcctgttt caatgacgat tttttcttct gtgtcaaacg 2353021 tccgtttcat cagtacaaat agattcatga tcatatcccc ttttattcgc ctttgaactg 2353081 aggctttctt ttttcgagaa atgcctggat gccttccttg gcgtcctctg actcaaatgc 2353141 ttccccaaat cgctttgctt caagctttaa gctgccttca taggaataca ccttgttgga 2353201 ataaagaagt tcaagcaaag atgccagcgt ttgcgggctt ttctctgcaa acttagcggc 2353261 aagtgctttt gctttttcaa tcacttctgc ctcatctttc gctccaattg agacaagtcc 2353321 gagatcaagc gcttcttttc cggatatcgg ttctcctgat ccgatgagct ccagtgcttt 2353381 ggctgtaccg acatatctcg gaaggcgctg tgtccccgca aaacctggaa tgataccgag 2353441 attaagctcc gggagcccca gcttagcatc ttctgccgcg attctgatgt gacaggccat 2353501 tgcaagctcc agcccgcctc cgagagcagc gccgtgaatc gctgcgataa tcggttttgg 2353561 aaaactttcg attctctcca ttaactgctg gccgcgctca gcgagcaatg aggaatcctc 2353621 attgccttta agcgatgtaa attctttaat atcagcgccg gctgagaaaa atcttccctc 2353681 gccgtgaatg ataatgcttc gtacgcctgc atctgtctca cattgatcaa gacaggaaga 2353741 cagctcttct aatatccggc ttgaaagcgc gtttgccggc ggattgtgaa tcgtcaagac 2353801 tgccacaaat tgatcaaccg caagtgaaat tgcattcata ggacagaact cctttactta 2353861 ttgtgaattc cggataccaa taattctaaa acgctgtttg aaagcgcaac gagatcgtac 2353921 ttttggtcat tcatcaccca agttgtcaca gtttcgtcaa tcgttccaaa aatcatctgc 2353981 cgggcgaggc ggacatcgag gccttctttt atttcgcctg attgtatacc ttccgtcaaa 2354041 atgccatcca aaatatttaa gtagcctttt aatatttcgt tgattttttg gcgcagctcc 2354101 aagttggatt ggcggagctc aagctgcgtg acaatggcga gattatggtc acccgctaaa 2354161 agggaaaaat gctttgaaat cacaagcgcc aatttctctt tcgctgttgc tttttcttta 2354221 atgtcctctt ccatccgctc aataaattga cccatttttt ctttgaaaag agaaattaaa 2354281 atatcttctt tgtttttaaa atagagatag atggtgccgt ccgctacccc ggcttgtttg 2354341 gcaattttgg atacctgtga ctggtggtag ccgttttctg caatgacttc tactgctgca 2354401 tcaataatct gcatatactt tggccgtttt tgcttcaatg ttcatcgttc cttcctatag 2354461 aaatgaatga ctattcattc ataatttcat gataagaagg attttcaggt ttgtcaagtt 2354521 tattcatagg cgttctcttt ttttatttga tatgatgatt ttcggtttct tcttcaagta 2354581 aacgccttct taaaattttt cccaccgccg ttttcggcag ctcctttctg aactcatagg 2354641 ctttgggcac cttataggga gctagacgtg atctcgcaaa agcgtccagt tcttctgtat 2354701 cggcttttgc gcctttcttt aatacgacaa atgcttttac tgtttctccc ctgtaggaat 2354761 cgggaacgcc tgcgacaaca atttcctgga tggcttcatg ttcataaagc gcttcttcta 2354821 cctcacgcgg gtaaatattg taaccgccgg caatgatgat atccttcttc ctgtcagcaa 2354881 tatagaaaaa gccttcttca tccatatagc ccatgtcccc ggtgaacagc cagccatctc 2354941 tcagcactgc ggcggtttcc tctggtttat tccagtatcc tttcatgact tgcggacctt 2355001 ttacaatgat ttctccatgc tcatacggag cggcaagctc acccgtctct tcagaataga 2355061 tcgcagcgtc cgtactcggc caaggacagc cgatactgcc cggcttgttt tttccccaga 2355121 taaagttggc gtgcgtcact ggggatgcct cagacaaacc atagccttcc acaagctttc 2355181 caccagtcac cttttcaaat ttctgcttta cctccacggg gagcgcggct gatccgctaa 2355241 gacagctttt aatggatgac agatcataat gctgcaattc agggtgatgc aaaaggccaa 2355301 tgtaaattgt cggtgcgcca ggaaagagcg tcggtttgtg tttgtcgatg attttaagtg 2355361 tttcgagcgg atcaaactta ggaagaagaa tcatttcgaa gcctagttta atcgaatagt 2355421 tcatgactgc cgtcagtccg tagacatgaa aaaatggaac gatgcccagc actttttcag 2355481 cgccttcttt cacgtcatac atccaagcgg cgcacatttc agtatttgcc aaaatatttt 2355541 ggtgcgtgag catgacccct tttggagctc cggttgttcc tccggtatac tggaggacag 2355601 cgatatcatg ctcaggatcg atcttcggga ttgtcaggag ttcagttttt tcctgcttca 2355661 tacaggaagc gaacgtgtga atgttagctg ttttgtcaaa gtcgatatgc actttttgtt 2355721 tttgcgtcag cgggtaaaga atatttttcg gaaaaggcaa atagtctttt acactggtta 2355781 tcaaaatctg gtcgactatt gataacgttt tcatttttat tgccttcggg aaaagcaaat 2355841 ctaaggtgat gattacactt acctgagcat ctctaagctg gtattcaagc tcatgctcgg 2355901 tataaagcgg attcgtctgc accacgatgc caccggcaaa caagacgcca taataagaaa 2355961 tcactgtttg cgggcaattg ggcagcataa cagccactct gtctcctttt tgcaggccat 2356021 tgcactgcaa aaaagctgca agtttaagag catccgtcag aatgtcatga aaggtgagtt 2356081 tttttccata aaacgatatt gcggttttat cagggaatcg tgcggcggag tctgtcagga 2356141 tggattgcag ggttttattc ggcaacggaa gctcatgcgg gatatcgttg ggatactcgg 2356201 caagccacgg cttttgagac tgcataaaac ctcccctttc gattttagag atccacctta 2356261 tcattatagc agatggacgg caaaaaaaag aaaaagaaag gtaaatcttt ctttttctca 2356321 taatatgaac agatatataa gaccaattaa caaaaagatt cccgctgcgg cgagcagtat 2356381 tttcgcaagc ttttccatct attctccgtc cccttatatt ccggctgcca ccacaaaaga 2356441 aagcccgaca gaaatgacaa atgaaataaa gccgacagcc cggttatcat tttcgatttc 2356501 ctgatcaatt ttaaaccgcg gagtcaaaaa ctcaaaaata aagtagctga tcagaagcat 2356561 aacaaacccg taaacgcccc agccgatcat ttgcagcagc gaattatgct gggagatgga 2356621 atgctgaaat acgtttgcga ttcccaaaat ttttccgccg gtcgccattg ccaccgcaag 2356681 atttcctttt tgaatctctt cccagttttt ataagccgtc accagctcaa acacagtcaa 2356741 aaagaggacg aggcagagaa ccgcgacact gtaatatgcc gcgatttcca caagctcgtt 2356801 ttcccaaaaa tcactcatgg ccatactccc ttttatttta gttcaacaac cgtaacgcct 2356861 gatcctccct cacctgcttc accgaaacgg gaacttttga cgctgcggtg gtttttcaga 2356921 agatcctgta cgccttttct taaagcgccg gttccttttc cgtggatgat tgacactctt 2356981 ggatatccgg ctaacaccgc atcatccaag tatttttcaa cccggctgag ggcattttca 2357041 tagcgttcgc cgcgaagatc aagttcaagc gatacgtgat agtcctttcc tttgaccgct 2357101 gtaatcattt tttctttttt tggctccgga gctgatttga taaactccag atctttttct 2357161 tttactttca tctttaaaat accgatttga acgttccatt cattgccgcc tgttttttcg 2357221 agcaatgttc ctttttgccc gaaagtgagg actttcacct cgtcgccagg cttaaagtcg 2357281 cgtttttgcg ttttcggctt ttccggtttc ttggactttt caaaagcagg catagcgcct 2357341 tctaaccgtt tcttcgcgtt aatcagctcg tgatccttga aggatttgtg ttcttctttt 2357401 atggtgcgca attcatgaat aatgtcctcg gcttctttca ttgccgcttt tactttttca 2357461 gcagcctgct gttctgcctc ttcaagcatt ttgtcttttt tgctgttaag ctcgatgatt 2357521 tgctgctgca gctctttatg cagtttttcc gcttcttttc tgattgattc tgtctcagaa 2357581 agctcttctt ccgcacgttt tttgctttgt tccagcgacg caatcatcgt atcgacttcg 2357641 ttatgctcgg ccgtcatttc tgacttcgcc tgcccgatga tatggtccgg gagcccgagg 2357701 cgttttgaaa tttcgaaagc attgcttcga cccggcacac caattaaaag tttataggtc 2357761 ggtgacagcg tttcgatgtc aaattcaacg ctggcattca tgacgccttc tctgttatag 2357821 ccgtacgcct tcaattccgg ataatgcgtc gtagctaaca ctcgtgcatt ggtgcgatgc 2357881 acgtcatcca agatgctcat ggcgagggcc gccccctcct gcggatctgt ccctgcacca 2357941 agttcatcga aaagcacaag gctgttttca ttgacctgtt ctaaaatgcc gacaatattc 2358001 accatatggg atgagaacgt acttaaactt tgctcaatcg actgttcatc accgatatca 2358061 gcgaatacgt gctcaaatac tgccgcttct gacccttcat ctgccgggat atgaagacct 2358121 gactgcgcca ttaaggttag caggcctaac gttttaaggg tgactgtttt ccccccggtg 2358181 tttggccctg tgatgacaat ggttgaaaaa tcgcggccaa gctcgatgtc attggcaaca 2358241 acctgatcag gcggaagcaa tggatggcgg gcttttttca aacggataaa gccggtgtcg 2358301 ttcataatcg gttttgtcgc tttaaccgct tttgcatatc tagcttttgc aaaaataaag 2358361 tcaagcgtct gcagcacttg caaatctaga aatagctcct ctgtatactc tgccgttttc 2358421 tctgtcagca cacgcaaaat ccgttcaatt tcttgctttt ctttcacttt cgcctgctga 2358481 agggaattgt tcatatctac aatcgcctgc ggttcaatga atagtgtcgc accagaggat 2358541 gaggtgtcgt gcacaattcc tccatagctg gatctgtact cctgtttgac cgggatcaca 2358601 aagcggtcat tccgaatcgt aacaatcgta tcagacagca ttttcgatgc ggaagaggaa 2358661 cgcagcatcg actctaaccg gtctctgact cttgattcga gtgttctgag ctgtgtgcgg 2358721 attcctctta atgtttccga tgcatgatca agcacttctc cgtgatcatc aatgcaggaa 2358781 ttaatgtccc gctctaaatc ggacagcgtg ataagctgtt cagcatgctg atggatcagc 2358841 ggaatgtcga caccgtcttc agccatttgc gtgataaaat gtttcatttg tttaactgca 2358901 taaagcaggc ctgagatttc agtgaattca gaaggactga gaacgctgcc gatttccgcc 2358961 cgtcttaacg ctcctctgat atctacaagg ccgccaaatg gcgcttggcc tctcagccgg 2359021 ataatgtcag aagcttcgtc tacttcatcc agctgttttt tgatttcgtc tatagaagca 2359081 gaaggcttaa gctcgagaag catttctttt ccgagcgatg aagcggcatg cccaataacc 2359141 tgttctttca ctttatgaaa ttcaagagct gataatactt tttgctgcac gattgtgtga 2359201 gcctccttac ttaatcgttg cgcttcagaa atgcctctac gtctttaagc gaccgggcat 2359261 tcagaacgtt tttcgtttcc gtccatcctt tgcgcgcggc agtaacgcca gttttcatat 2359321 cgtctaacat ctcaatatta tgggcatcag tattaatcac caatgtaacc ccttgttcgt 2359381 ttgctttcat taaatgctct gtgcgcagat caaggcgcgc agggttggca ttgagttcaa 2359441 gcgccgtatt tgttttcctc gcaagctcaa tcagctgatc aatatcgatt tcgtaaccgg 2359501 cccgtctgcc gataaggcgc ccggtcgggt gtgcgataat gtcaacatgc ttgtttgtca 2359561 gtgccgtctc aagccgtttc ataatcacgt gttccggctg attaaaactg gaatgaatcg 2359621 atgcaataac gatatccatt tccgcaagca catcgtcatc ataatcgagc gtaccgtcag 2359681 gcaggatatc catctcaacg cctttcaaaa tacggaagtt ttcaaactct gcattcagcg 2359741 cgtcaatttc ttttgcctgc tgcttaagtc tttctgcagt aagcccgttg gcgaccttta 2359801 aatattgtga gtgatcggtg atcgccatgt attgatagcc ttttttgatg caggcttcag 2359861 ccatctctct gatcgaaaat gcgccatcgc tccacgttga gtgcatgtgg agatcacctt 2359921 tgatttgccc gagctctatc agttcaatgc tgtcgctgta ggtttccact tcctgtccgc 2359981 tttcacgaat ttccggcgga atcagcggca ggccgaagtg cgcataaaat tcacgttcac 2360041 tcggaaatgt tttgatctct ccggtttcaa ctgtctcaac gccgtattca ctgatccgct 2360101 cgccgcgttc tttggcgatt tggcgcatct taatattgtg atcctttgat cccgtaaaat 2360161 gatggagtgt tgtcggaaac tgctcttccg tcacaagacg gaaatcgacg cttgtttcat 2360221 attcaaagga aaggatgacg gacaccttcg tatctccgct tgcgatcacg cttttgatgt 2360281 ttggcagctc aagaagctgc tctcttactt cagccggatg atctgtagca atgatataat 2360341 ccagatcctt caccgtttcc cgcgctctgc ggagacttcc ggcacgagaa aatttgatga 2360401 tatgcgtaaa ttgagaaaga tgctcctcaa tttcccgcgc gatccggagg gcgtagccga 2360461 tcgggaaccg ttcaggctgt tttccggctt ccccgagcgc ctgtaatatt ttttcttccg 2360521 attttttgcc gaagcccgca agaccctgga ccttttgctg ctcacaggct tccttcagag 2360581 attctgcatc gtgtacgccg agctctttat acagctttgc gatttttttg ccgccgagcc 2360641 ccggcagctt caataaaggc acgagtcctt ccggcacttc tttctgaagc gattcgagcg 2360701 tgcttgactt tccttcatct atatactctt taatgacgct gtacgttcct tttccaatgc 2360761 cggacagcga catcatatcg tccatttctg ataagcttcg gtcgtcctgt tccagagctg 2360821 ccgccgcttt tcggaaggcg gatactttaa acgggttgtc ccctttgagt tccatataga 2360881 ctgcaatggt ttcaagcagc cggataatat cttttttatg catatcataa cccccagacg 2360941 ttcacatatg tttccatcat acttgaaaaa aacttctccg gacaagagaa gtttttttat 2361001 gccccgtact gtgtccacag ctcttgtaaa agccctgaca agtacggtgt atggttaatg 2361061 atcacatttg cgagagacga ttgccccatc atttgctgca acgcgtctac cggcagaacg 2361121 gatgcgacat acagcagcac aaatgtaaat aaatagactt ctagaaaacc gagaacggct 2361181 cccagcatct ggttgatttg tttaatcacc ggaatgccgg ctacaatact caggaacgag 2361241 ccgatgattc tcagtaagat tttagcaatg ataaataaaa cgataaacgc aatcgcatta 2361301 tagtacgctg cttccaaatt ccccgtaaaa aaagaaagag ccggctgtcc cgctgaaaaa 2361361 tcgggtgcgg gaatccaatg taaatgcggt gccacgtttt tatagaataa agccgcaaag 2361421 gcaattgata aaataaagct cgtcaagcgg ataaactgca ggataaaacc gcgttttaac 2361481 cccagtaaag tccccatcag gagcaagatt aagatgatga tatctagcat agttgttcaa 2361541 tccttttctt taagctgacg ctccagtttt tcacatttct cttgtaattt gacataatcg 2361601 tgcaccacat ttaccgctgt cagcactgca agtttattta tatcaaggta tggatttttt 2361661 tcattgattt ctctcatttt atcatcaaca attccggcga catacctcat atgggctctg 2361721 ctttcttcac cgacaatcgt gaagtgctgg ccgtaaatgt caacggttgt ttttgttttt 2361781 ttgccgtcag acaacgtttc tcctccattc cgcgagaatc ctagttctta tcataacacg 2361841 tttattaaat gaatggaaag acgagcctcc cgctgttatg atacactggt atatacagcg 2361901 aaaagtgtaa aaaaaggaga ttattacgtg tcccattcag tgataaaagt atcgttgtct 2361961 gctattgacc aaatgaaaat gacgtacagc ggttcactta cagcctctgt tccgcaggga 2362021 gccgtttttc aggcaaaacc gcccggctgt accattacag catatcaatc aggtaaggtc 2362081 ttgtttcaag gaaaaaacgc tgcggcagaa tccgcgcgct ggggaacagc agagcctcag 2362141 gaaaagaaga aaacggccaa aaagccggct gatccccgct atgcccctcc ggcagatatc 2362201 gccggaatgt ctgttatcgg ttctgacgaa gtcggaaccg gagattactt tggcccaatg 2362261 acggttgtat gcgcgtacgt cgacaaaacc atgcttcctt taatgaagga actcggtgtt 2362321 aaggattcta aagatttaaa agatccgcaa atcatcgaga ttgcccgaaa cctgattaaa 2362381 accattccgt acagcctgct ggtgttaaag aatgaaaagt ataacagcat gcaggaaaaa 2362441 ggcatgagcc aagggaaaat gaaagctttg ctgcacaatc aggcgatcac acatttatta 2362501 agaaaattgg atggagtaaa gcctgaagcc attttgattg accaattcgc tgagccaggc 2362561 gtctacttca atcatttaaa gggcagagac attgtgaagg agcggaccta ttttagcaca 2362621 aaagctgaag gtattcacct ggctgtcgcc gctgcttcaa tcattgcaag atattcattt 2362681 ttaatggaaa tggataaact atcacgcgcg gcaggaatga cgcttccaaa aggggccggt 2362741 ccgcacgtcg atgaagcggc cgccaagctg atcctcaaaa aaggggcatc tgcactcaga 2362801 acctttacaa aactccattt cgccaatacg caaaaagcgc agcgccttgc tgataaaaaa 2362861 cgttcataga aaaaagcttg cagatttctc tgcaagcttt tttatcagcc tcttaaaaca 2362921 gcttgatatg tgtcttctaa cgctttcagc actttgctgt gcgcctttgt cacttcttct 2362981 tcagtcagtg tttgttcagg attgacatac tggagtgaga aagcgactga cttcttgcct 2363041 tcctccatat gctctccttc gtatacgtca aatacggtta cctctttcag aagcttgccc 2363101 ccggcctctt taatgacgct ctcgagctgt ccgcttgtga cggttttatc tgttacaaga 2363161 gcgatatcac gtgtcacaga cggatatttt ggaatcgccg tgtaaacaag cggtgctgtt 2363221 tctgctgcga gcaacgcatg aagatcgagc tcaaatacgt atgtttcctt tatatccagt 2363281 tctttttcca atgaaggatg gacttggccg atgaagccga tcagagaacc attcaataaa 2363341 atgttcgctg ttctgcccgg atgcagctgt ttgcgttcag actgtacaaa ttcaatgctg 2363401 tctaggacgt tgagtttgtc taacagccct tccacaattc ctttgacaac aaagaaatca 2363461 actggtttct tttcaccctg ccatagctgc ttgcgccata atccggtaac agctcctgct 2363521 acgcgttctg tttcaacagg ttttgtgtcc tcttccttcg ttaggaaaac ggagccaact 2363581 tcgtacagtg caactgagtc agtctgcctc gcaagattgt aagaaacaga atcaagcaga 2363641 tttggaacaa gactgtgtct gagaatgctt ctttcttcac tcattggaag cgcaagcaca 2363701 gtattcagtg atttttcaat cgcaaacgct gtcgctttct tctcgtttgt cagtgagtaa 2363761 gtgatggctt gtgataagcc tgcgccttca aggaagcgtc tgactttacg gcgttttgcc 2363821 tgatatggcg ttaatccgcc tgtagttccc gctgtctcag gaagcgtaga cggaatgtta 2363881 tcgtagccgt acagtcttgc cgcttcttcg attaaatcct cttctattgt aatgtcaccg 2363941 cgccgtgatg ggacagtcac aacgagaaga tcatccgctt caccgaccgt aaaaccgaga 2364001 cgtttataaa tgctgatcag ttcttcttta ctgatcgtca ggcctagaac gctgctcact 2364061 ttgtcagcag atacgtgaat gttatttgct tcgattgtca ggtgatcttc ctcaaccgtt 2364121 ccagcaagca cctcaccgcc ggcatacaga tggatcagct gcgcagcccg ttctgctgca 2364181 agacgtacgc gtgccggatc aattcctttt tcaaatctta cgcttgattc acttctcaaa 2364241 ccaaggtctt tggaagcctt gcgaaccttc tgcccgttga aatacgcagc ctcaagcaaa 2364301 atggttttcg tatcttcctg aacctctgac tctgctcctc ccatgacacc ggcaacggcc 2364361 tgcgctttcg ttccgtttgt aatgacaagg tgatcggcag acagcttacg ttcttgatca 2364421 tcaagtgtta cgatcatttc attctcagct gcttttctta ctacgacttc cttagagcca 2364481 aatctgtcat aatcaaacgc atgaagcggc tgtccgtatt ccaacaggac aaaatttgtg 2364541 atgtcaacga cgttgttgtg cggacgaatg cctgcattca tcagctttgt ctgcatccaa 2364601 agcggtgacg gagcaatcgt gacattttta atgatttttg cagtgtacag cgggttcgct 2364661 tcttgatctt caattttgac tgaaatgtaa tcagacgctt gttctgaagc agccgggtaa 2364721 tccgtttgcg gaagctttac ctcagtgtct aaaatcgccg caacctcgta agcaacacca 2364781 agcatgttca tggcatccgc gcggtttggc gttaaaccca gctcaagaat cgcatcgtca 2364841 agctgtaaag ccgctaaggc atcgcttcct gtttcagcgt cattcgggaa tacgaaaatg 2364901 ccttctgcat actccttcgc cacaagtttg ctttcgatac caagctcctg taaggaacag 2364961 atcatgccgt ttgattcttc accgcgaagc ttggcttttt tgattttgaa attgcccggc 2365021 agcaccgctc cgactgttgc aactgcgact ttttgtccct tatccacatt cggcgcgccg 2365081 caaatgattt gtacaggggc ttcagctccg atatccacaa ggcacttatt cagcttatca 2365141 gcattcgggt gctgctcgcg ctccagcaca tggccgatga caacgccttt gatgccttct 2365201 cctttgtatt caattccttc aacctcaata ccggctcttg taattttttc agcaagaaca 2365261 gccgggtcca tgccttttaa atcaacataa tcctctaacc atttataaga aacaaacatc 2365321 cttgcatcct cctcttacgc ctgtttaaac tgcgaaataa atctgacatc gtttgtatag 2365381 aagtggcgga tatcatcaat gccatatttc agcatcgcga tgcgctcaac acccattccg 2365441 aatgcgaagc cctgatattc cttcggatca aagccagcca ttttaagcac gttcgggtga 2365501 accattccgg caccgaggat ttcaatccag cctgttcctt tacatactga gcagccgttc 2365561 ccaccgcatt taaagcatgt cacatccact tctactgaag gctcagtaaa cgggaagaag 2365621 cttgggcgga gtctgatttc acggtcttgc ccgaacattt ttttcgcaac aagttcaagc 2365681 gttcctttta aatcactcat gctgatgttt ttgtcaacga caagcccttc aatttgcata 2365741 aattggtgag agtgcgtcgc atcatcgtta tcacggcgat atactttacc cgggcaaatg 2365801 attttaacgg gacctttgcc ttcatgcttt tccatcgtac gtgtttggac aggagaagtt 2365861 tgcgttctca tcaaagtttc ctctgtgatg taaaagctgt cctgcatatc gcgcgctggg 2365921 tgttctttcg gaagattgag cgattcgaag ttgtagtaat ccgtttcaac ctctggccct 2365981 tcctcgactg tgtagcccat accgataaat aaatcttcaa tttcttcaat gacaacagtg 2366041 agcggatggc ggccgccgac tgcaacaggg ttccccggca gcgtgacgtc aattgtctgt 2366101 cctgcaagct tctgtttcat ttcctcttct tcaagcttct cgtttttgtc agcaatcgca 2366161 ttggcaatac gctcccttac ttcgttcgcg agcgccccca tttttggacg ttcctcagca 2366221 gaaagcttgc ccattccgcg cagcacttct gtaatcggcc ctttttttcc gagatattgc 2366281 acccgaatat cattgacaac cttcaatgag cttgccgctt ctacttgttc taaagcttct 2366341 tgttccagct gttttagctt ttcttccatt ttgcatcctc cttttatgta aacaaaccgt 2366401 catatgtctt tggaaaataa aaaaaacccg tcccttgtac aagggacgag ttgtggccgc 2366461 ggtaccaccc ttatttcaga cagactgatg ctgtcgtcag cttcattgac ataacggaat 2366521 cagattccgg ttcaccttta cgcgcagtgt acgcggtccc ggcgacaact caagaggtga 2366581 agccaatttc cggctgcgtt aaaaatgctc tcagtcagcg gcattttctc cctggaaagc 2366641 agttgatcag aaattgaggt cctctgtcac ggtttttgaa atattatgtt ctattataga 2366701 gaaatccaac gcttggcgca acactatcct cgcaagtgat acacgaggat ggcagccgca 2366761 accgcaacgt ttagtgattc agcctgtccg taaagcggca cgtacaggtt caaatccgtt 2366821 ttttccagca atgcagcatc tacccctgca ccttcatttc ctacaatgag cgcaaaggat 2366881 tcagactgag gaatctcctg gtaaggcgct ccgttttgca gcgccgtgcc gtatactttt 2366941 acgccctctg ccttcaattc gtccacatat gaaggcaggt ttcttctcac aacaggaata 2367001 tggaagtgag atccttgagc agatcgcagt gtttttccgt taaaggcgtc cgccgtgccg 2367061 tcaccgagta caaccgcatc caaaccggcc gcatcagccg ttcgaatcat tgtgccaagg 2367121 tttcccggat cttgaacagc gtcaatcagc agcaccttgc gtgccgttgc cagcttttct 2367181 tcaggcatat ggcacacagc ggcaatctgc tgcggcgttt cggtttcagt cacagctgaa 2367241 aacgcatctt cactcagcat atagcactgg ataccagtct caagatctga aggaatcctc 2367301 gtttcatcct ttacaaggat ttctttcaca atgcccgggc ttttcaacgc ctcttcaacg 2367361 aggtgttctc cctctatcag aaatgtattt gtttttgttc gttctttttt tgtgtgaagc 2367421 tttttccaat ccttcacttt ttggtttttt gccgattcta tttgtttcac tgtctatgtg 2367481 gcgctccttt ttttaacatg atgttattat atcgcaagaa cagcacataa taaaccaggt 2367541 gcagggttag aatatacgta ttacatttta gaaaaaggag cgttttacat ggatcttaat 2367601 ttacgtcatg ccgtcattgc caatgtcacc ggcaataatc aggagcagct tgagcataca 2367661 atcgtagatg cgattcaaag cggtgaagaa aaaatgcttc cagggctcgg cgttttattc 2367721 gaagtcattt ggcagcacgc atccgaaagt gagaaaaacg aaatgctgaa aacgcttgaa 2367781 ggcggattaa aacccgccga ataagacatg aaaccgggtg acagcgcccg gtttttttct 2367841 tatataataa aaacatgatg agggggaacg ccatgttttt acagccgtta ttagcgaaaa 2367901 aaattattgc tgaagttaaa aaaatgtacg aacgtgaagt cattattgta aacacggacg 2367961 gtcttattat ggcaggcaca aacgatgagc gtgtcggaca atttcatgag ggagcgctta 2368021 tctgcgcaaa agaaagacgc agcgtgatta ttacaaaaga agatgaaaca aggttaaaag 2368081 gagtgaaagc aggcataaac ctccctgtat tttttgacca tgatgtgatt gccgtcttcg 2368141 ggctgacagg tgagcctgca gagattcagc cattcggaga actgcttcga aaaatgacag 2368201 aactgttcat taaggaatcg cggcacttag agcaatccca gtggcgtgag agaatgctgg 2368261 agtcctttat gatcgattgg ctgcaattaa aggagtggtc tcccagtttt cttgagaaag 2368321 ctcagcttct tggtgttgac ctttcttccc ggcgccaaat gattcttatt caggggtatg 2368381 agtggtcacc tcatgatatt gaacaaatgg cacgcagctg gaaatcctcg taccctgcgg 2368441 atttgttcat caggtgggga aatgaacgga ttttgattaa tcatgaagtg ccgcagcatg 2368501 aacaaaggga tcggcttttg cggaaaatcc ttcacatttg ttcgtttgcc aataccgcaa 2368561 gcagccaata tacagcagct ggcgccggaa gggctgtcgc aagctccagc ctgacagatt 2368621 catacgagca agcggaaaaa gcgctggctg tcagccttaa gcgaaaaacg cccatatttg 2368681 aagaggatct gaagcttgat atgtgtctga cggagatcag cccgggaacc cgaaacgaat 2368741 ttccgcaaag agtattagga aaggcgctag agcatcagga acttatgaat acgatacgga 2368801 ctttctttca tcacgatttg tctttgaaac aaaccgctga agacatgcat atacacatca 2368861 atacattgcg ttatcgtctg gctaaggctg aacagctgac gggattacgt tttgaccgta 2368921 ccgaggacgt cgtcacgatg tacgtcgcac tctatttttt agatcaagat acaaaataga 2368981 gagagtttca gtttcatttt ttgtatgttt ctccatggaa ggctttgctt tttttctttt 2369041 acaatagatt gaaagcgttt tttgacaggg ggatgggtga aatgatcacc aaggatgtaa 2369101 aggagcagct gattcaggtc tccggaccag aaaactttga tgactcgaat gccggccgtc 2369161 tcgtctattc atatgatgcg acgcctcagt atcagtctat gcctgatgcc gtgattgctc 2369221 cgaggaatac tgatgaaata tcacgcattt taacaatttg cagcgaacat cgagtgccga 2369281 tcgttccaag aggatcaggg acaaacctgt gcggcggcac gtgcccgact gaaggcggac 2369341 ttgtgcttct ctttaagcac atgaaccaga ttcttgaaat tgatgaagaa aatttaactg 2369401 ccacagttca gccgggcgtc attacgttgg atatgatccg ggcagttgaa agcaaaggtt 2369461 tattttatcc gcctgacccg agttctatga aaatatcaac tatcgggggc aacatcaatg 2369521 aaaattccgg cgggctacgc ggattaaaat acggtgtcac ccgcgactat gttattggac 2369581 tggaggttgt tctcgcaaat ggtgacatca tccgcaccgg cggaaaactc gcaaaggatg 2369641 tggccggata cgatctcaca cgtctttttg tcggctcaga aggaacactc ggcattgtga 2369701 cagaggcaat cgtcaaactc gttccaaagc cggaaacaaa gaagacgctg cttgcccttt 2369761 atgaaaacat cgatgccgct gctcaaacgg tatcggacat tattgccgca aaaattatac 2369821 ccgctacgct tgaatttctc gatcagccta cactattggt gattgaggat tatgccaaaa 2369881 tcggacttcc gacaagcgca aaagcagttc tgttaattga acaagacggg ccatttgaaa 2369941 ctgttgaacg ggatatggaa aagattgagg cgatctgcaa aaaaggcgac gccgtatccg 2370001 ttcagaccgc acaaacagag gaggaagcgt ttgccctgac tgaagcccgg cgttctgcac 2370061 tttctgccct agcccgcctc aaaccgacga cgattttaga ggatgcgacc gttcctcgct 2370121 cagaaatcgc caatatggtt aaagcgatta atgatattgc tgctaaatat gatatttcca 2370181 tctgcacctt tggtcatgcg ggagacggga accttcaccc gacatgcacg acagacataa 2370241 gaaataagga tgaaatggaa cgtgtcgaac aggcttttgc cgagattttt gagaaagcga 2370301 ttgaacttgg cgggacgata accggagagc acggagtcgg ggaaatgaaa gcgccttact 2370361 tggaaatgaa gctgaaaaaa gaaggcattg atgcgatgaa agcgttgaaa gcggcatttg 2370421 acccccggaa catattaaat cccggcaaaa tgtttgcgaa agatgccaga aaacgtgtgg 2370481 tggcggaaag atgacaacag aaaaagaaat gaaacagatc caaaatgaat ttaaagagcg 2370541 tatggatgaa ggagagttat taaattgtat gcgctgcggc ttctgtcttc cttcctgtcc 2370601 gacctatatc gaatcgggat ttcaggaaac acactctccg cgtgggcgca tcgccttaat 2370661 gaaagccgta gccgacggta tgattgaacc ggatgaagat gtcgaacggt cgctgtcact 2370721 ttgcctcggc tgccgcgcct gtgagcctgt atgcccgtct ggcgtgaaat acgggcagct 2370781 gcttgaggaa gccagagata ttatccacca aaataaaaaa cactctcttg gtgaacgtgt 2370841 catgcgaaag acggcttttc acgagctgtt tccgcatcaa aaccgcatgc gctcagctgt 2370901 aagccttatc ggtttgtatc agcgttcagg actgcaaacc gctgtgcgaa aatcaggcat 2370961 gcttcgggtc ctgcctgagc atttgcggac gatggaagct gttcttcctg atgttccaaa 2371021 aagcaaagac atgaaacatc ggccgcgttt cctgccttcc attggcccca tgaaaaaacg 2371081 ggtcgccttt ttttcgggct gcttaatgga tacaatgttt ttaccgacca ataacgccac 2371141 attgaagctt ttacagctgg caggctgcga cattgtcatt ccgcctgaac aggcttgctg 2371201 cggggcgctt catggacaca gcggtgaaaa aaacacaggg aaagagctcg cgaaacaaaa 2371261 tatcgctgct ttcgaagcat tagacgtgga tgcagtcatt acaaacgcag gaggatgcgg 2371321 agcctttctc actgaatatg atcatttgct gaaggatgac cctgagtggt cggaacgggc 2371381 tgccgctttt gttcaaaagc tgaaggattt ttcttctgtt ttggttgaac tcgatttcca 2371441 tcaaatggat ctagcactcg agacgcctca ggtcgttacc taccaagatt catgtcatct 2371501 aagaaatgtg atgcatacgt cacttgagcc ccgccagctt cttaaaagca tcaaaggggc 2371561 ggaattcaaa gaaatggaga aagcagacag ctgctgcggg tcagcgggaa tttacaacat 2371621 cgtcgaagtt gaaatgtcta tgaaaatact ggacagcaaa atggctgccg tcaaagcaac 2371681 cgaagcgatc ctcattgtaa cagcaaatcc tggctgcctg ctgcagatga agctcggcat 2371741 tgaacgcgaa ggactaagcg gtaaagtcag agccgttcac ctggctgatt tgctattaga 2371801 agcagccggg cacaaaacat catgagaaag cccaaaacag acattgtttt gggcttttgt 2371861 gcgttattcc atcggactgc aaatttcgat ataatgtcca tccggatcag cgatataggc 2371921 gaccgtctgc ccccatggtt tcactttcgg ctccccgata atcgatacgc cttgttctct 2371981 catccttttg atgaccgctt ctacattttc agtaacaaac ccgatttcaa atgtgtttga 2372041 agcagatgta tccggaatgt ccagcgccgt gatgtctctg gcgctttccc gggtattaag 2372101 cgccaatatc gtagaccctg tatcaaattc gacatacgtg ccgtgttcag cacgaatcgg 2372161 cagtcctaaa atatcccggt aaaaaatgaa tagcccgctt gctgtccgat acgtatagaa 2372221 taagatattt cattgataga ttcattgcca acccctctca gcattttcaa tagtccttct 2372281 agcccggtat agatgcttcc atccttaagc tcggatcttt ccacatctgc gcccattttt 2372341 tcacagccgc cacgataatg atgaagccta acaccagcat gatgatagat aatacgccat 2372401 tcaatacact atatcctgct gcttcaggat tgagatacac attgcgcacc atccaatagc 2372461 ccgcataatt gacagtgaca tataaatagg caagcgggat aaggcaagtc agaatgtacc 2372521 ggcgtttatc ggcgattttc agcacgatcg tcgctccgat aatcagcccc actgaagcca 2372581 tcagctgatt agaaacgccg aagagcgccc aaatggaacc gatatctcct gaatacagca 2372641 agtaccccca catcaaacag gcaagcgcgc tggcaaatac agagcccgga atccagtctg 2372701 ttttcttcag cggcttatac acctccccga agaagtcctg gatcaaataa cgggcgacac 2372761 gtgtgccggc gtcaatcgct gttaaaataa agaccgcttc aaacataatg acaaattgga 2372821 aaaagtatga ggccaaatgg ctgaaaaacg gcattccggt aaaaatataa gtcatcccta 2372881 ccgcaagcgt gacggctccc cctgttcttc cttctaagtc caaaccgatt tccccgctca 2372941 attcaggcaa atgtacgaca ttcatgccaa gcgtacggaa aacctcaggc gtgctgttaa 2373001 tcgcaaagta atcagcaggc tgtaaagcgg tcgctgcaat cagcgccatg ataccgacaa 2373061 gacactcaac aagcattgcg ccaaacgcaa ccggcttcat atcactccat ttattcagca 2373121 ttttcggtgt cgttcctgag ccgacaaagg catggaaccc agagatcgcc ccgcaggcga 2373181 tggttattga gatgaacggc cagacaggtc ctgccagcac cggccctccg ccttttacga 2373241 attctgtaaa cgcagggaac ggaatggacg gattgacgac aaacacacca acaatcaaag 2373301 cgataaaaac accgattttc ataaagctgc ttaaataatc acgcggagcc agaagcagcc 2373361 aaacgggaag cgcagccgca aaaaacgcat aaacaggaag cgcgattgca agcgttttcg 2373421 tatctagcgt taaaaagtca ccgagcgcgg tagtctgtac ccatggaccg ataaagactc 2373481 ctgccattaa aaagagaaag ccgaccgttg aagcgagctt taaatttccc gttttcttat 2373541 aaaataagcc cacacccatc gcaatcggaa tcgtaatccc caccgcaaat gttccccatg 2373601 gattacgttc aagcgcatgc aagacaacca tcgacaggcc cgccattgtg atcgtgatga 2373661 taaacagcat ggacagtcct gtacaaaatc ctgcaacagg gccaagctca tccttcgcca 2373721 cttccgacag cgattttccg tttttgcgca tcgatgcaaa caacaccaca atatcatgga 2373781 cggctccccc aattaccgcc ccgattaaca gccacaataa tcccggcaaa tagccaaact 2373841 gcgccgccag aattggtccg accagcggcc cggccgctgc gatcgcggca aagtggtggc 2373901 cgaacgaaac ccatttattt gtaggcacat agtctttccc atcctcaagc gcatgagcag 2373961 gtgttggctt gtcatcattc actttgagaa ccttcaccat cataaatgtt ccgtataaac 2374021 gataggcaat agccaaaata cacattgatg ctatcacaat tgtaaccgca ttcattttct 2374081 cccatcccct tttctgtttt tcataaatat atcataattt catggtgaaa agcggtcatt 2374141 ttttcctata caaaaagccg gctggaatgg gccggctcgt ggcagttgaa agacaagccg 2374201 gagagaaatc tccggctttg ctattcttat gactgttttt tcaggcggat cacattccag 2374261 gaaagcggcg tgaaatgagc agttaagccg ttttcgctga cagacgatga tccgttggaa 2374321 tgcggaacga cattttttct gttatgctgg tttgttgctt tgatatcctg atgctcaagt 2374381 acgatgtgct ctgcgatttg gtaggattca aagcctctga gcgaaatctc cgtctccatc 2374441 tgatcctcag ccttgtttac cgcaaaaata gtgagtgttt cttcctcttc agagtacaca 2374501 acagcagcat caacatatgg cacatcagtg aaatcagaac aatcgtactt aggagaagaa 2374561 ataagcggtt tcagtgactc gccccttccg taaacagaag catgcatgta tggatagaaa 2374621 atcggctgtc tccatgcttc tccgcctttt tccgtcatga tcggcgcgat gacattaaca 2374681 agctgtgcaa gacacgcaat tttcacacgg tctgcgtgct gcagcatcgt aatgagcaga 2374741 gagccgacta ataaggcatc ttcaaaattg taaatatcct ctaaaatcgg acgcgcagtg 2374801 atccacggct cgactttttt atcagcctca tttgagtggt accagacgtt ccattcatcc 2374861 agagagagat tgatagtttt cttgctgcgt gtttttgctt ttacatagtc acaggtcgca 2374921 gcgactgatt tgataaaatg atccaaatcc atagaacgtg ccaagtagtt tggcagattg 2374981 ttatcccggt ttccgtagta agtgtgaaga gagatatagt cgacatgctc atacgtatgc 2375041 tcaagcacct tcgcttccca atcgataaag gtcggcatac cgctgtttga gctgccgcag 2375101 gcaacgagtt caattgatgg gtcaacccac ttcatgacct ttgctgtctc tgcggcaagc 2375161 cgtccgtatt catcagctgt tttgtggccg atctgccatg gtccatccat ttcgtttcct 2375221 aagcaccatg ttttgatgcc atacggctgt tcatagccat gcgatcttct taaatcactc 2375281 cagtaagagc ctttcggatg gttgcaatat tcaacgagat tacgggcggc atctatgcct 2375341 cttgtgccaa ggttgacggc catattgacc tcagtgttca ccttttttgc ccaagataaa 2375401 aattcatttg ttcccacttc attggtttct gtcgtttgcc atgccaagtc aagccgtctc 2375461 gggcggtttt cgactggtcc gacaccgtcc tcccagttgt atccggataa aaagtttccg 2375521 cccggatagc ggatgatggg aacctgtaat tctttgatca gcgactggac atcttttcta 2375581 aatccatctt catccgcttc agggtgatca ggctcgtata tgccttcata taccgcacga 2375641 cccatatgtt cgataaacga gccataaatc cgtttatcta cttcaccgat tttatattct 2375701 ttgtctacaa tcattcgcgc ttttttcatc acacgtttcc tccttcatta acctttgact 2375761 ccccctaccg tcaggccgga gataaagtac ttttggaaaa acaagaaaat gataatcacc 2375821 ggcaaaatcg caaatactga gccggatata agcatgtcgt aattatttcc ataagggctc 2375881 agcaagctgg acagccctat tggaagcgta aacatttctt tcgaccgaag cacaatcagc 2375941 ggccacaaga agttgttcca gctgtttaag gactgaagga taatcatcgc accgaaagcc 2376001 ggtttcatca gcggtgccat aatcctgaaa aagatgccga attccgtaca gccgtccatc 2376061 cttgcagagt ccagcagatc tcttggaagg ccaagagcat attgcctgaa aaagaaaaca 2376121 gcaacaggtg aaacgataaa cggcaatatg acacccgtat atgaatcgat caagtgcagt 2376181 ccgacagtaa gtttaaacag aggaagcatc atcacttcca gcggaaccat cataataatc 2376241 agcacaagaa caaagatgat atttctgccc ttaaaatcat aaaccgcaag cccgtacccg 2376301 atcatcgaag aaaaaaacag agtgagcaca gtcgtaaaaa gtccgagtac aagactgtta 2376361 aaaaaccatt tgaaataaat gctgccgcca ttaaacagaa atgtgtagtt atcaaaactc 2376421 atcacttttg gatcaatatc aagattcagc cccacacgca aaagctcaga tgacggcttt 2376481 aatgatccta aaagcaaaca gaaaatcgga aaaagataca ataggctcag catcataaaa 2376541 aacagggtca gcgcaattct ataaacgcta aactgaggac tgtgccgcaa catttatccc 2376601 tcccccttaa acgagcctga cagctttaat gaaatcaggc tgacaacaag gatcacaatc 2376661 aaaagcacaa tgccgatggc cgctccgtat cccatttcat tgtaggcaag tccctgctga 2376721 tacaaatatc cgacaagcgt cagaccaata ttacccgggg aattattctg ccaaaggacg 2376781 tagctttcct caaacatcct gaagccgccg atgatgctga tggtcagcac atatacggtt 2376841 acaggcttga gaaacggcag cgtgatgtgc agaaattttt tcattgtatt cgcgccgtct 2376901 atatcagcgg cttcgtacag ctctttcggc acattttgca aacctgctaa aaagtaaagg 2376961 atgttgattc ccatccatct ccatgaagca agcagcacca tcaaaaacat gccggtatgt 2377021 tcattgttca tccagttctg aggtgaaaag ccgagtttaa gtaggatgga attggccaga 2377081 gacgtttcca tttctccgaa gatcagccga aaaatgatcc ccgcgacaat ggttgaggtc 2377141 aatgccggga taaataatgc tgatttaaat atatttctaa atttgaccag ctttgaattc 2377201 aggaatatgg ccagaagcaa tggaacagga atcagcacga tcagcgtcca aaaggtgtat 2377261 tccagcgtat tccaaagggc ggtatagaac gtcgggttgt ttagcgctgt ataattagac 2377321 aatccgacaa aggacacctc tcccggcaaa attctttgga agctcatgat gaagacacta 2377381 atgatggggt atagaaaaaa tacgagaaag gataaaacga atggcgctgt aaacagatag 2377441 ggcgccgctt tttttgaata aaacagatct cgccagcctg attgtttcgc agctgaagga 2377501 acgggatgaa ccgttcccgt tttcacaggt ttcatgagaa cctccccgct ttcacttttt 2377561 gaatgggatt ctatttctgt ttcagttcac ctgccgctct gtccaaggct tgtttaggcg 2377621 ttttttgctg agatttaagc gcgtcgaaca atacgcttct gttgacaagg tctgaagcct 2377681 tggcaaaatc ctcatgtaaa taaattggat tgatttcatc cttgatatcg agcagcacag 2377741 aaaaaatgcc tgttccgttt tggaagtaat ccgtgtattt gtttttctct ttcaattcct 2377801 tggagctcca aacatcccag cgaagcgggt caaagccgag tacgctccag agttttttat 2377861 ttccttcttc agagcccttc gcaaaggcca aaaactcttt tgctaactca acatgcttgg 2377921 attgcttcgg tacaacagtt gccgtaccgc ccaaacctgc cgagcggtcg cccccctctt 2377981 tccatgccgg gagcggtctg atggcaatct tccctttcag atcaggcata taatcgataa 2378041 atcttcccat ataccaaatc ggcatgagaa ctgaagcagc tcctccttgg ttcataaagc 2378101 cgtagtattc ttcactgtga tgcccgccgc ccggcgcagg aatcatcgtt ttatcattga 2378161 tcatgtcttt taaatattga agtgttttta cgttggtgtc attattgagg atcagcttgc 2378221 cgtttttatc aaaatagcct gagttttgct gtgaaatcat agataagaac gttgcggaat 2378281 catttgtttc caccgttccc atcggcttcc cggtcacttt gcgcactttc tgtccggctt 2378341 tatggtaatc atcccatgtt ttaatatcgt caggattgac gccggctttt ttcatcacat 2378401 ccatgttata aaacatgacc gttgtcccta catgtgtatc gagtccgtaa agctttccgt 2378461 ttttgctgta caatgtcagc cgcgcctcaa cgaatttatc gcgatccttt tcaatcagcg 2378521 gagtcaagtc ggcaagcggt atgtcagagc ccttcaaaaa gtttgaaaaa cgggccaatt 2378581 cgacatctgc aatatcagga acgccttctc ccgctattag ggagatagat aagttatcgt 2378641 gcatttgtcc atatggataa acgaccgtat tcagcttaat tttgcggtca ggatattttt 2378701 tgttccattc cttcaccatt tccacataga actgctcatg aagcccgtta aatgtccaaa 2378761 aggtcagctc agtttcaccc gatttgccgg atgatttttc tgctgaacac ccggcaatga 2378821 ctaatgtcag caacatcatg agcacaagaa aacagacagt catttttttc atctgcgtta 2378881 ccccttccat tcgaggtgcg ggctattcat atagaccatg gttgatcagc gttttgtttt 2378941 cattgatgat tcttaatccg gtgcatcggt ctcttaaggt gtgcgcgtgt ctgaaggcat 2379001 ttttgacgga atcctgcccg acaccgattt cgtcaaaata cgcagggcct ccggctgatc 2379061 tcagccaatc agccagcact tctcctctcg ggagtgtttg ataagccgat tggatggctt 2379121 cccggcggct tggtgaaaat tcgttcagcc cgtcatcctg agcgagcttt ctgtatgtgt 2379181 cagttaataa aacagcggca cagcccacct ttgccccatg aagaatctga ggccgttttt 2379241 tctccattaa ctccatttca atccaatgtg aaatatgatg ctcgccgcct gatgccggtc 2379301 gggaatgatc taatgccagc atgacaagcc ccgatacaag taaagactcc atcaaaaccc 2379361 gtatgccagt ttccgttttc atcgcaatgt cttctgtgtg ttcaatgcag gcagcaagcg 2379421 cctcctgaac gatcttagct cctgcaggcg aataaggctc accggcaaga tgccgggata 2379481 tttcccaatc tgctaaagac gtgattttac cgagcatgtc accaaagcca gccgccacca 2379541 ttgactgcgg tgccgctttt aatagatcca gatcagcgaa cagcgcagat ggggccttcg 2379601 tttgaatggt tgttttcgtg ccgtataaaa taatcggcgc accggctgat gtaaaaccgt 2379661 ctacagatgg agcagtcgga taagaaataa acggcaaatc tctttgaaac gccgcaaagc 2379721 ggacgatatc atgaatcgtg cccgaaccga ctgcgatcat gacatccgtt ggttgtttcg 2379781 tatggatcag cacatgaatg agcgatcgtt catcagctgt cacatctccg gcttcatttt 2379841 ctggaatgat caggcactcg gcctgaaatc cttcttgatt cagtcggttt tctaaatcaa 2379901 ttcctgcaat gcggtgtgta ttcgcgtcgc agacaaggac aatatgttga ttgttttttc 2379961 gttttacata atccaaaagc gaatcagctg cttgcttacc gagaacaatt tcttcaactt 2380021 ttataggcaa cgtcttttct ccggcgtttt caaaagcacg ctgaacgtca gctgcgatac 2380081 gattcatatc agaatcccct cctcagccaa tttggttaca tccttaatag aatccagcac 2380141 ataatccggc gtgtacaaac gctgttcacc ctgtttcgca gaaccagtta gcactaaggc 2380201 gcttttcatg ccataaagct tccccatcgc aatgtcagat tcaatgctgt ctcctataat 2380261 catgcattca tgtgcggaca gccccattgc tgtacaggca gcctccgcca tcagccatga 2380321 cggttttccg acaacaagtt cagtcttcgc ttgtgcagaa gtctcaattg ccccgatcat 2380381 tccggccaca tcaatggcat ttccgtcttc gttcggaaaa gagcggtctt tgtttgtagc 2380441 gataatacga gcgccgccgg cagccgcttg aaaggcttga tttaaatcgt cgtacgtgag 2380501 cgtttcatga agggagatca cgagccaatc cgcttccttc ggttcgctcg cgttctgcac 2380561 accggccagc ctcagctcgt caaccaagcc ttgctcccca agcacccata cctttgaaaa 2380621 acgataatgt tttttcagaa aagccgctgt cacgcttgat gacagaacaa tgtcgtttac 2380681 gtccgtttca atccccgcgc caagaagttt ttttctgcac atggcacggg agatattccc 2380741 ccggttgctt aaaaagacga ttttctttcc cattctccta agcgttttga tcgcttctct 2380801 tgctccttcg atcaactcat ttcctctgaa tacagtaccg tccaagtcaa tcagaatgcc 2380861 agccggtgac acaggcgtat catgactggc cataatacgc atttgctccg tgttttcgat 2380921 aaaaatgctt ttcatgcagg actgtattga ttggggttac atccttgttc agcataatgg 2380981 agtgataggc catttcggca accgtttcta atacaactgc gttatgaatg gcatttaagg 2381041 cgtcagtgcc ccagcagaac ggtccgtgat tattcacgag cacacccggc acctgttcgt 2381101 aattatgatg ctgaaaggtt tccgctatga cttttcctgt attcagttcg tagtcatgaa 2381161 tgatttcttc atcgtacatt tctcgagtac atggaatcgc actgtcaaaa taatcagcat 2381221 gggtcgtgcc taacggaggg atgtctctgc ccgattgcgc ccagcttgtc gcccattgag 2381281 aatgggtatg gacaattccc ccgatattcg gaaaggcttt atatagataa acatgggtag 2381341 gtgtatctga agaaggttta agcgagcctt cgacgacctc tccatcaagg ttcaaaacaa 2381401 ccaagtcatc ggctgtcagg tcgctgtatt cgactccgct aggtttgatg acaattcttt 2381461 ctttttcacg gtcaatgccg ctgacatttc cccacgtaaa ggttaccagc tgatgctctt 2381521 gaagcttcag gttggcagcc agcacttctt tttttaatgt ttcaagcatg ctccatcacc 2381581 ctttatcaat tctttttggc ggcagatgaa aattgaagat ttttgatcgt tttcagacgc 2381641 ttcatgacat ggttttcttt tccgaaataa tgaaccagct ctttatattc agcgtacaat 2381701 ttttcataaa ccgcggcgtt ttcggcattt ggcgtataag ttatatcttt cagttttccc 2381761 atgttcgccg ctgccttttt gatatcatcg tagccgcctt tttctttgcc tgctgcaagc 2381821 gcgccgaaaa tggcagatcc taaggctggg gcttgcggtg aaccagagat tttaatgtcc 2381881 atgtttgtca catccgcata aatctgcatg acaaacgggt ttttctcagc tattccgccg 2381941 gctgcgaaca gttcctcaat cggaacaccg ctttctttga atgtttcgat aatcatccgg 2382001 gttccgtaag ctgtcgcttc aactaacgct ctataaatct cttcaggctt cgtcagcagt 2382061 gtcatgccaa gcagcatccc tgttaaatct gcatcaacaa gagttgaacg gtttccattc 2382121 caccaatcta aagcaagcaa gccgctttca ccaggcgctt gatggtttgc tttctcactc 2382181 agcagctcat gaacgccaat gtttttttcc tttgcttcct cttgataagc tggcgggaca 2382241 catgttttca caaaccagtc aaaatgatcg ccgacacagg actgcccggc ttcatatccc 2382301 gcatagcccg ggagaattcc gttgtccaca acgccgcaca ttcctggaac gatatgcacc 2382361 tcttcaccaa gtagaacatg gcacgtcgag gttcccataa tcatcagcat tttccctggc 2382421 tctgtaatgc cgaccgccgg taccgaaaca tgagcgtcca cattggcaac cgcaacagcc 2382481 gttcccggga gaagccctgt cagctttgcc attttttcag tcagactgcc ggctttttct 2382541 cctactgaat gaatagaacc tgacaatttg tcctttgtaa tcgttttcat tgaaggattt 2382601 aatttctcaa agaaatcatc tgacggatac cccgcttttt cactccacat cgctttatac 2382661 cctgcggtac aattgcttcg cttgagcgag ccgcacagct ggtacacgat ccagtccgca 2382721 gcctcgatga tccggtcagc cgcttcataa atgtgaggcg cttcctcggc aatttgcatg 2382781 acctttggaa tcatccattc tgatgaaatt tttcctccgt accgctgtaa aaaagcctct 2382841 ccttcttctt ccgcgatttg attgagccga tcagcatgtt tttgggccgc atgatgcttc 2382901 cagagcttca catagctgtg cggctcctct tcatattcag gcagcatgca taacggctgc 2382961 ccgctgctgt caataggaag gatcgtacat gccgtgaaat caattccaat cccgataatg 2383021 tctttcgggt caacgcccgt ctgttcgagt aaagacggaa tggttgtttc caagacttcg 2383081 aggtaatcag cagggtgctg cagcgcccag tcacgcggca gcttttgacc cgtttttgga 2383141 aggacggtat caatgacagc atgcctgtat tcttttacag cagccgcaag ttcctcccct 2383201 gtttggacat gaacgagcac tgctcttcct gataaagttc caaaatcaac ccctattgtg 2383261 taagccatgt gacatccccc tctacttttg aagccggtaa agcgcctcgt tccattttaa 2383321 ctcgtgtttc agtttatgaa ttgtcgtatc acgggaaatg agaacacttt cgattcccgc 2383381 catttccgcc caatcaagca tttgctccgc tgtcagttca taagacaggc aggtatggtg 2383441 tgcaccgccg gctaaaatcc atgcctccgc tgctgttttc aatgacggct ccggcttcca 2383501 gagaacacgg gcaaccggta aattcggcat gtctttttca atttcctggc cgttgacttc 2383561 attcagcaca aggcggaaac gcccgccaat atcaacaatg ctagcttgaa tggcagaacc 2383621 gctgatgccg ttaaatacca aacgcgcagg gtcctctttg ccgccaatcg aaagcgaatg 2383681 aacctcgatt ttcggctgat ccaaagcgac agtcggacac acttcaagca tgtgagagcc 2383741 cagaatcatt tcatttcccg gttcaaaatg gtacgtgtaa tcttccatga aggaagttct 2383801 ttttccttta gccatgattt tcatcatccg tacaagggcc gctgtcttcc aatctccttc 2383861 accggcaaac ccatagcctt tctccatcag gcgctgaacg gcaagtcccg gcagctgttt 2383921 cattccgtgc agcacttcaa acgatgtcgt aaacgctgtg tatccgcctt gctcaagaaa 2383981 agcggttaat ccaagttcaa ttttcgcctg ttctttaatg gacgctacct ttgcttcgtc 2384041 acgttttgtt tcctcactga tcacatatag tctgtcatac tcggcataaa gcgtgtcaac 2384101 ctcgtcgtcc gtaatgcgat ccatcacttc aacgagatcc ccgatgccat atccgtcaac 2384161 ctgccagcca aattgaatat gcgctcccac cttgtctccg tccgttaccg cgacatgacg 2384221 catgttatct ccaaatctgg caaccttaat atgtctgctt tcatttaatg cagccgccgt 2384281 atccatccac tgggacattt cttttttcac ttcttcatca tcccaatagc cggcaatgac 2384341 ttttcggcta agccccattc tcgagttgat gtaaccgtac tctcgatcgc catgcgcgga 2384401 ttggttgctg ttcataaaat ccatgtcaat cgtaccccac gggatatcgc gattatattg 2384461 ggtatgcaaa tgcataagcg gtttttgata agaggaaagg ccttctatcc acatttttgc 2384521 aggggaaaat gtgtgcatcc atgtaatgat gccagcacat gtctcactgt actccgcttc 2384581 tcttaacagc tctctaatgg tttccggtga agtgacgacg ggcttatgag tgattttata 2384641 tctggaagaa atcccgctga gcccctcaca aatgctttta gcatgctgat ctacgagttc 2384701 cagcgtctct tccccgtata ggtgctggct tcctgtcaca aaccagaatt cataatcctt 2384761 tgtctgaagc atgtaaactg cccctttctc ataaaataaa acgctttcaa atacaaaaga 2384821 tacgtactaa tgatagaaaa taaacctata aataaatatt tgtacgaaca attttattat 2384881 agtaattgac tattatactg tcaatctttt cttttaaaaa aagccggggg cagagcccgg 2384941 ctttttaatt caataggacg gccagcccga gctccaattc aaatcattga tgagaagctt 2385001 tggaatgccg ttgtcattgg catcataggc atggcgaaca agaatgtttc cgttcacaat 2385061 atcctggcct ccaggtcctt tccattggtc attgcccgaa tccaaaatgg tgcctccgcc 2385121 ttcaagcatg ctttttccgc ttttatcaag ataagggcct gtaatgcttt tggatcttcc 2385181 gtaagcaatt ttgtacgtac tgtttacccc gtcacagcat ttatcaaatg aaaccattaa 2385241 atagtaatat ccattttgat acgtaagagt aggagcttct aaggcacctc cattattcgg 2385301 tctagctgca atcgaataga gcgagcctgt aggcttcatt gtactcttat cgagcttagt 2385361 cagcttaatg ccgctccaaa acgagccgaa tgcaagccac gggttgccat ccttatcgaa 2385421 tgtcagctcc ggatcaatgg cgttataatt atttgagctt gtcgaacgga tcaccaagcc 2385481 ctcgtccttc cagccccccg aactgatgct tgttgaagat gccaggccaa tggcagatgt 2385541 attgcttcca aaagaagaaa cggaataata tagccagtac ttgccgttat agtattggat 2385601 gtccggcgcc cactggtttt ggccataatt cggcacataa ttggaccacc acgatagcgg 2385661 tgtagtgaaa atggattttt gtacggtcca atttttagcg tctgaagact tcaaaacccg 2385721 cagtccccgt tcttcagtaa gccctgttcc gagcgcatac catgagctcc cctctttaat 2385781 catagtcggg tcatgaagca gctcattgga tgcaccccaa aacgctgcct ctgcgggagc 2385841 agcagaagtg aatatcaaac ctgcagccag agctgcactc gaaaagtgta agaagcgttt 2385901 ccatgttttt ttctttttca attttgttca acctccttta ttttagaaag cgcttacaaa 2385961 ttagattatt tatcctccct tcctgtcaaa tcgactgcgt atcgtatatc gtcatgttca 2386021 ggaaattttc ggtatcccct ttattgtagt cactatgctg taatttgtac agacaaaaaa 2386081 atagaatcca cctcaatagg cggattcttc cgtatcttta ttggtacgta atttcgtcaa 2386141 ccgtttttcg gtctaacttc ttaatgactt ctgtaattaa ctttaccgcg ttttcataat 2386201 catcacgatg cagcatggcc gcgtgcgtat gaatgtagcg ggttgcaatg gtaatggaca 2386261 gcgcaggaac gccatttgcc gtcaaatgga tggcacccga atcagttccg ccgccggcaa 2386321 tggcatcaaa ttggtacgga atgccggctt cctccgcagt ggctacaact gcatcgcgca 2386381 aacctttgtg agagaccatg gatgcatcgt aaacgataat ctgcgggcct ttgcccattt 2386441 tgctctgcgc ttccttctcg gaaatgccag gcgtgtctcc tgctatccct acatcaacac 2386501 caaacgcaat atcaggctga atggtgtgtg cagccgtttt cgctcccctc agcccgactt 2386561 cctcctgcac ggttccgacg ccatacacta tatttggatg atctgtgttt tgtaagtttc 2386621 ttaacacatc aatagcaatc gcacagccga tgcggttgtc ccaggccttt gcgagtagga 2386681 atttttcatt gttcatgacc gtaaattcaa aatgcggaac gatcatatct cccggaagta 2386741 caccccactc caaggcttct tcccggcttg aagctccaat atcaataaac atgtctttta 2386801 tttccactga tttttttctt gcttcaggag acaaaatatg aggcggctta gatccgataa 2386861 cccctgtgat ttctcctttt tttgtgacaa tggtgacgcg ctgagcaagc ataacctgag 2386921 cccaccagcc gccaacggtt tgaaaacgga taaagccttt atctgtgatt tgtgtcacca 2386981 taaagccgac ttcatccaaa tgtccggcga tcataatttt cgggccgttt tctgcaccag 2387041 ttttttttgc aattaaactg cccaggcgat ctgttgtcac ctcatcagca aatggttcta 2387101 tgtatgattt catcacttgc cttacttctc tttcattgcc cggtatgcct tttgcatctg 2387161 ttaaatcttt cagcatggtc aatgtttcat ctaattttgc catgttccaa accctccttc 2387221 atcagtcctg cattcttatt atacaaaaca tggcgctaac catacgacta tttcacttga 2387281 aaatcgggta tatgttttta cagctttctt ttagaaaaag tgaaaccttt ttctatgctt 2387341 ttcgtattac atcagatcat caccataagg gaggtgcctt cacacaatgt ttgtcatggt 2387401 tctaaggatt attttgcttg cactttttgc ttattgtatt tatgccgtgg tcaaatatgt 2387461 cgcgaatcct aagagaaggc ttaagctggc ccaatcaaaa gaacattttt atattattga 2387521 tgaacaaaac aatacccgga agaattttca gctgacgtat aaaggcgtgc tttttgaggg 2387581 agaaaagcat attccttcca aggatcatcc gctgtttatt cacacgatct ttgtctggac 2387641 agaatctcct gagaagctga aacatttctc tgcaaaagat tttgagaaca ttgaagaaaa 2387701 agtgctggaa cgatatccaa attgtaagat tgactgggac cagcccatta aactcgcaaa 2387761 aaaagcagaa gagcgttaaa cgcttttctg ctttttataa atcaaacggg ctgtagtaaa 2387821 tagcgatgag aatcgcttct attaccagaa gaagcggtac tccgtactta aaagaagcgt 2387881 gtttcgtttt atgtctgaag gtttgcatgc caagccagac accgagcgct ccaaacacga 2387941 tggctatcag ccacagccgg tcttcagaaa ttctccactt gtgctgctgc gctttgcgtt 2388001 tgtcaatgcc catcacccaa aaaccgcaca gattaatcaa caccaaataa gcagcaataa 2388061 tcatgttgcc tcatccttta tatagaaaaa gccgctctgc tggagagcgg ctctatatga 2388121 ttacttgttt aattgagctt tagcagcatc agcaagctga ttgaatgcag taagatcgtt 2388181 tacagcaaga tcagcaagca ttttacggtt tacttcgata ccagaaagct taagaccgtg 2388241 cattaaacgg ctgtaagaaa ggccgttcat gcgagcagct gcgttgatac gagtgatcca 2388301 aagtttacgg aaatcacgtt ttttctgacg acggtcacgg aaagcatagt ttccagattt 2388361 catgacctgc tggttagcta ctttgtataa tgtatgtttt gaaccgaaat aaccttttgc 2388421 taatttaaga acctttttac gacgcttacg tgtaacagtt ccgcctttta ctcttggcat 2388481 tgaatttccc tcctaattgt tccttatccg attacttgat gttagcaagc atttgtttga 2388541 tacgtttgaa gtctcctgcg cttacaacag cactcttgcg aagcttacgc ttttgctttt 2388601 gagatttgtt ggcgaataag tgacttgtgt acgcgtgaga acgttttaac ttcccagaac 2388661 ctgtcttttt aaaacgttta gcagatccgc ggtgagtttt catttttggc atgggatttc 2388721 ctccttattg cttttcgttt ttcggtgcga gcattaagaa catgctgcgg ccgtccattt 2388781 ttggttttgt ttcgactgtc gcaacctcag cacatgcttc ggagaaacgg tctaatacac 2388841 gctgaccgat ttctttatga gtgattgcgc gtcctttaaa gcggatagaa gctttcactt 2388901 tatcgccttt ttcaaggaat ttaatcgcat tgcgcaattt cgtgttaaag tcatgctcat 2388961 cgattgtcgg acttaaccga acttctttta agttaatgat tttttgattc ttgcgtgctt 2389021 ctttttcctt tttctgctgc tcaaatcgga acttaccgta gtccatgatt cggcagacag 2389081 gcggttttgc attcgctgca actaacacaa ggtcaagatt tgcgcggccg gcgatttcaa 2389141 gtgcttcctg acgggacttg attccaagct ggtcgccatt ttgtccgatt aaacggacct 2389201 cacgtgcacg gataccctca ttaaccaatt gatctttgct aataatgagc cacctccata 2389261 gtttcttcga attgattcac aactcatttt gaatgcattt tgcaggcaaa caaaaagtgt 2389321 gggcattata aaacacccac actacgaaca tctgtatcaa taaaaatgta cggtcaacct 2389381 gccaactaca tgcatgtgtc aatcaggtga gaagcgggtg cttctgcttg tgatttatat 2389441 tcaattcaat aactattcta cacaataccg gatctttagt caaggacgac ttatccggaa 2389501 caacttttac attgtaacat gggttttcta tgagcgcaag agagaaaaag aaaatctttc 2389561 atccccaccc agaatacaaa gaaccaacaa ttccccctta ttacgcaatt tacaacaaaa 2389621 ccaccgacag gaagaaatgt aaaacaaagt taatctctga ccgatataag gagcagaagg 2389681 gagcctgaca catgaacaaa ctgatacagc ttgctttatt tttcacattg atgttaaccg 2389741 gttgctcgaa tagcagcaca tcttccgaat caaaagtcga aaccactgtt aagacaacgg 2389801 cagcatttcc tcaaaaggag ctggagaaag agctaaaaaa actaaaaccc gtttcattgg 2389861 acatgaagtt cgagagtcca ctcgctaccg agttaggaaa gcggaaggca aaagaggaag 2389921 ctgaaaagca aagacaaatc gccgctgaga aaaagcttga aaaagagcgg gaggcgaaac 2389981 gaaagaaaca gcaggaggaa aaagcggaga gacagcgatt agcagagcag caggctgcag 2390041 agagacagcg attagccgaa gcggaaagac aagctgaact tgaaagacag cggcaggcag 2390101 caatccaaaa agagcagaaa gcgaacgctg agaaaaagcg gcaatcgcag gcacaacggc 2390161 agcagactga ggcaccctca tctaatagtc aagatccacc atcttcctcg agtcagacag 2390221 ataaaaccat tcaacagcca gcttcagagc ttcctgatga cgatggttat ggttatgaag 2390281 aacgaaaaaa gtggcatgac gatcaagtag aatggggcat taaacaaggg tatatcgatc 2390341 ccgaagacgc accataaaat aaaaaaagcc aaggcattca gccttggctt atcctccgat 2390401 cagctgcacg aacacaggga tgaccagaac cgttaccact cctactacga caacagcaat 2390461 acttgccatc gcagcttcaa cttctcccat ctcaatcccg accgctacac caagtgcatg 2390521 tccggatgtt ccaagagcca atcctttaga aatcggattt ttcactttaa acaccttcaa 2390581 gaacaatgct ccgagcgcat atacgatgac agcgttaaag atgaccgcaa aggctgtgat 2390641 gtcgctgatg cccccgatgc cttttgataa aggaagcgca attgccgttg tagccgcctg 2390701 cggaagcatg cttttcatta cggccgaatc gagatgaatg cctttagcga gcagataaac 2390761 aatcgtgaca gagcagatag agccggcaat aatggaggcc atgatttgcc accagtactt 2390821 tttaagctta tctctttgtt tgtacaaagg aattgcaaat gcgatcgttg ccggttcaag 2390881 aaaaaactta atgatctctc ccccgttatt ataatccgcg taggaaaaac cgccgatttt 2390941 taaaaatgcg atccccagca ccatggcaac aaacaaagga gtgaaaagga agaagccttt 2391001 cgttttctta aataaaaagg tgccgatgcc gaatgcagca agtgatacga caatcccaaa 2391061 ataaggactc attgtgcttt ccatgtgaag aacctcctgt ttcccttaat ggtgaacgag 2391121 ttcgttattg ttctgcgggc tttgcactgt ttttgttttc atgtccgctt cggttttgcg 2391181 ttttccgctc agcgacagaa tcagctgaga aaacaatccc gtagccccca gcaaaataat 2391241 cgttgcgagc agaatgacaa gaacaatttg caggccgtat tgctgcatca caccaagcga 2391301 attcataaca gatatacctg atggaacaaa taaaaatccg atcagagagg ttaaagacgt 2391361 tccgagcgtc tccacttgtt ccagtttaat gactttcaaa cataatagga gaaataataa 2391421 gaccaaccct acaaccgatg ccgggatagg tattgggaca atagcggcaa tcatatttga 2391481 aaccagcata atgacggcaa aaataaatgc ttgtgttaaa aacccgtaca cttttttagc 2391541 actcattttc ttcacctctt tctctttggt accctcatta taaataagaa ttccctgtta 2391601 taaagcgctt acaagataac atgccgtata gcgggtctga gttgcagaat caaatggctg 2391661 aaatgcaaaa agccgcccat caaatatgga gcagcttttt caattccttc gcatatgtcc 2391721 ggctgaccgg tattttcgat ccgtctttca tgatcagatt atacgttgaa ttaaaccatg 2391781 gctgaatttc tttaatatat tcagtattca cgacaaagct ccgatggacg cggataaaat 2391841 cagaatccgg cagctttttc tcaatcacaa cgagtgtatc gctgaccgta taagaatgat 2391901 cgaaggtttt tacattgaca tgaccatctt ctgttccggc atagataatg tccttcgtat 2391961 ccacaatcac aatcgattcc cccacagata gcgcgagctt gtgctggccg gcatggctgt 2392021 tttgctctgt ttctacaata tcccgattga cttttttata ttttttcagc gtttgctgaa 2392081 ttctttcttc atcgaaaggc ttggttaaat aatcaagagc gtccacctca aacgctttga 2392141 gcgcatactg gtcatacgct gtcgcaaaca caatagcagg aggatgcttc attttcttca 2392201 atcgctttgc gatatcaaaa ccgttttctc cggataaatc aacgtctaaa aacagcaaat 2392261 caggtttttg atccatcatt tggtcaaaag cggattcgat attttccgct tcattgattt 2392321 ccatttcatc attggtccgc ttaagcaagt aagccagttc atcccttgcc agcatctcat 2392381 catcaactat taacaccctg agcatgttct tctccctctt tcatctgttg cattggcact 2392441 tgaaaggaaa cctctgtccc tttatgaacc tcactgctga tatgcagtgc agcctgctgt 2392501 ccgaataaac cgatcagccg ctgatttagg ttataaagcg ctgtaccggt tccctcctta 2392561 gacggaaacg gtttcttccc cagttccggc aagacgtccg gcggaattcc gcgtccgtta 2392621 tccgccacct tcatatagac ggatgcatca tcagataaga cacagactgt aaccttgcat 2392681 atgtcttgtt ttttcggaaa cgcgtgccga agcgcgttct cgacaagcac ctgcaaaaca 2392741 aacggaggga tttcaatctg ctccagtctg ctgtcgatat taagctcaat tttatatttc 2392801 ccgggaaaac gcgcctgttc taatgacaaa taggcgttaa gatggttcag ctcctttgag 2392861 agcggaatca gcagctgtct cgctccttga aggtttgaac gaaaataaac actgagctgc 2392921 aataggagct tacgggtttt ttcaacatct gtacggcata acgcagaaat cgtgttgatc 2392981 gcattaaata aaaaatgcgg attcacctgt gcttgaagcg ctttaatttc agcatccttg 2393041 agaagtttgc tttgcagctc tgcttcccca agctcaagct gtgtcgaaaa cagcatggcc 2393101 agcccctcgg caagttcctc ctctacctga ctcaggcctg ccgggctttt aaagtacatt 2393161 tttaaggtgc cgattgtatt gccgttcgat gtcagcggta ggacaattgc agcgtgcaaa 2393221 gggcattcag catgcgtgca ttcaatctct tcctgcgaaa tcgccttcat aatatgccct 2393281 gttttaatca cctttttgga caggccggtg atcaagcttt tcgatgggat gtggtgatcc 2393341 attcccgcac cgacatgcgc aaggatcttt tctttgtcag tgagagacac cgcatctgtt 2393401 cctgtcagct tatggataat agccgctaca cttttacagg agttttcatt taatccttgg 2393461 cggaaaaatg gaagtgtctg atcagcaatc gtaagcactc gatgcgtttc gagagccctt 2393521 gcctgttctt ccttgcgaat gatcgcttga ataatagaca gaaaaataaa actgcctgtt 2393581 ccattgatga gtatcatcgg aattccgatc atgctgacaa gctcccaagc gtcactgaac 2393641 ggctttgcca tcagcaaaat aatgatcatt tgcagtgact ccatgccgat tcccacaaga 2393701 gcggcgatgc gcggtgtcgg cattcgatat cgcttcgtaa aatacctgcc gatcaagcct 2393761 gcaagaacac ccgctaaaat agatgagacg gcacagctta aggccgtgct gccaccgagt 2393821 gaaaaacgat gcaggcccgc aagtatgccg atcccagccc ctacaaaagg acctccgaga 2393881 aggcccccga tttccacgcc caaaatacgg gtattcgcga tagagcccga tggatctatc 2393941 gtaaacaccc agtcattgtt tacaatcata tttctttgaa tttcgatgcc tgtataattg 2394001 ctgatgatgc tgaaaagaga aaaaatagaa attaaaatcg cttttccttt atagccgtcc 2394061 tgattctgaa gagcttgtct gaaaagtttc gtatgggcga gaatgaaccc taatataaca 2394121 ataatcccca ctctctccag catcataatc attaaatgaa tcattcatgt cacctgttct 2394181 ttccgttttc attctagcat gttttcgttt tgcggctgac tgttttttta aaatcgtctg 2394241 aaaacatatt tcacaaggct tttatctatt gtaaaataaa acatgagcct tttggcagaa 2394301 agatttgaat ctgaagcaga ggagaagatc atgaaagccg tattttttga tttagatgat 2394361 acactacttt gggacgaaaa aagcgtcaga acaacatttg cagaaacttg cttacaggcg 2394421 gagaaaaaat atggccttgc ccctgaggaa ttcgaagcag ctgttcgcga agcggcgaga 2394481 gaattgtaca tgtcatatga gacgtatcca tatacagtga tgatcggcat taacccgttt 2394541 gaaggactgt ggtccaattt ctcagagcca atcagtgaag gctttcaaaa gctgaacaag 2394601 attgtgccgg agtacagaag aaatgcatgg accaacggac tgaaagcgct tgggatcgat 2394661 gatcctgcat atggcgaata cttgggagag ttttttgcgg cagagcgcag aaagcgcccg 2394721 tttgtatatg atgaaacttt tgctgtactc gatcaattaa aaggcaagta tgaattattg 2394781 cttttgacaa atggcgatcc tagtctgcaa aaggagaagc ttgccggcgt gcctgagctc 2394841 gctccttact tcaatgaaat cgtcatctcg ggcgcattcg gcaagggcaa gccggatgtt 2394901 tcaatttttg aacactgcct taagctgatg aatattgaaa aagacgatgc catcatggtc 2394961 ggcgataatt tgaatactga tattttaggc gcttcaagag ccggaatcaa aaccgtttgg 2395021 atcaaccgga ctgataagaa aaacgaaact gacgtaaagc ctgattacat catcagcagc 2395081 cttcatgatt tgtttcctat attagagaaa taaaaaaagc atgatctctt caatgagatc 2395141 atgctttttt attttatttt ttcgcttcag ctactgcctt tttcacaaac tcatcaagtg 2395201 aaatggtttc agagttctgt tctccgtatt tacgcacgtt taccgctccg ttttctgctt 2395261 cttggtcacc gaccaccagc atgtacggga ttttttgcat ttgcgcttca cggattttgt 2395321 agccgatttt ttcatcgcgg ctgtcgactt caacacgcag gccttcacat tgcaggcgtt 2395381 cctgcacttt tttcgcgtag tctaaatgca cagccggaga aaccgggatg acttggaact 2395441 gaaccggtgc aagccatgtc ggcagcgcgc ctttgtgttc ttcgattaag aaagcaacaa 2395501 agcgttccat tgttgaaacg acacctctgt gaatgacaac cggacggtgc tgcttgccgt 2395561 cctcaccgat gtatgtcagg tcgaaacgtt ccggcaataa gaaatcaagc tgaaccgtag 2395621 acagtgtttc ttcttttccg atcgcagttt tcacctgaac atcaagttta ggtccgtaga 2395681 atgccgcttc accttctgct tcgtaatagt cgtggccgat ttcatccatt gcctctttca 2395741 gcatggattg cgctttgttc cacatttcat cgtcatcaaa atatttctct gtatcttccg 2395801 gatcgcggta agacagacgg aatgtgtaat cacttaaacc gaagtcttca taaacatcct 2395861 ggattaaacg gactgtacgg ataaactcat ccttaatttg atccgggcgc acaaagatgt 2395921 gtgcatcatt taacgtcatt ccgcgtaccc gttgaagtcc tgacagcgca cctgacattt 2395981 catagcggtg catcgttcca agctctgcaa tacgaatcgg aagctcgcgg taactgtgaa 2396041 tgtcttgttt gtaaatcatc atatggtgcg gacagttcat cggacgcaat acaagtgttt 2396101 cattgtccat ttccatcgga gggaacatgc cttcctgata atgatcccag tgtcctgatg 2396161 tttcatacag ctctttgctg cctagcacag gtgtgtatac gtgctcatag ccgaggctga 2396221 tttctttatc gacaatgtag cgctcgatga cgcggcggat tgttgcgcct tttggcagcc 2396281 aaagcggcag gccttgtccg actttttgag agttcgcgaa cagctttaat tctttgccaa 2396341 gctttctgtg gtcgcgttct ttcgcttctt ctagcatacg aagatgctct tcaagatcag 2396401 cttttttgaa gaaagctgta ccatatacgc gctgaagcat ttggtttttg ctgtcaccgc 2396461 gccagtatgc gcctgcaagg cttaacagct taaattcttt gatttttccg gttgaaggaa 2396521 catggacgcc gcggcacagg tcaaagaatt cgccttgctc atagatcgaa acggtttctc 2396581 cttcaggaat cgcatccaat agttcaagct tcaggtcgtc gccgatttcc gcaaaacggg 2396641 ctttcgcttc ttcacggctg acttcttttc gaacgatcgg aaggttcgca ttaacgattt 2396701 ttttcatttc tttctcgatt ttcggcagat cctccggtgt aatcgcttcg tccatttcta 2396761 catcgtagta aaaaccgttt tcgataaccg gaccgacgcc gaatttaaca tccttgtaga 2396821 tgcgtttaat cgcttgagcc agcaagtgag ccgcactgtg gcgcataatt tgaagacctt 2396881 cttctgagcc ttctgtaatg atttccactg taccgtcttc attgatcggc gttctcaaat 2396941 cgatttcttt tccgttcagt tttccggcta atgacttttt ctttaatccc ggactgatgg 2397001 atgccgcgat atcttctgtt gttgttcctt tcgcaaactc cttgactgct ccatcaggaa 2397061 atgtgatttt taccatatct gacatctttg tcactccttt ttttgcatat aaaaaccccg 2397121 ccccctatga aagggacgag gttgaataaa cggaatcgtg gttccaccct tttttccgca 2397181 aagccaatac acggcacctg cggctctaag ctctgtaacg ggagttcccg tcagccatta 2397241 ctgttccttt tcaagaggtt cacagctgaa gttcaaaggc ggtaaagcga atggtcctta 2397301 gctgggaagc ttgcagccag ggcttccctc tctttgagcc ggtatcattc cttcgtgtcc 2397361 ttatcaatac gtgtgtcttt cttaatctcc tatgtattat aaattgttca atccaaaaaa 2397421 tcaacacgat cgcgtttcct tttttttaaa ccgacagcct taaatagaca ggctgccggc 2397481 cctcatcctt ccgagtgctt caccggtatt tctgcatctg taaaagcatg cagcgggagc 2397541 atttccactc tctcttgaaa tacgttttga atggtccttg ccatcatgtg ctcgggctgg 2397601 tcggtataaa gcacgacttc atcaggcgca atggaaatca gcggcgcgag caaatgagaa 2397661 tcaatataca taggatgatc ccggacaaat cttctgtcta tgtatttcat tttttcccgt 2397721 tccggcacat agcgcagctc ccataatgta aaggaaccat catggacaat atgcactttt 2397781 ttgattcgcg gctgtttggc gtccacatag tctctgagtg tttgaataaa gttttgatat 2397841 tcctgttcca tcttatattc atcaatcgct gcttctgtaa tatctctcag ctgcttatag 2397901 tatgatccaa gtcggaaggt ctgaaaggag cgaatgtaaa atactccttc ctctaaacag 2397961 atcgtttgga gttcatccaa aattgattgt ttccgtgaaa gcttcagcgg ctcaaacgga 2398021 agatcgtctg cttcaccttc aataatactg tgtgcgagct gaaggatttg ctgctgttca 2398081 tcctggtccg tgaaacaata cgtttcctca atcaatgaca gcatatgctc gtcttctttg 2398141 cattccaaaa aaaatttgac cagaatcggc tccataaaac gctgaatagg aaaagccgga 2398201 ttcgcttttt caatcccgat ttttcgtatg ccttcacgga caatgatatt gttccgatcg 2398261 tccgaatgct gaatgagatg taaaaaagcg gctgcatcat ggtcatcttc aaagattatt 2398321 tcaagcatgt ttgtcccccc ttacggcatc tgttacaagt atatggggga tgtttttaaa 2398381 atagacgtaa aggtcattgg caaatcttaa tttgattctt ggaacaagtt ttgcattttc 2398441 tttctgaaga tgaacggcaa tgagataaac acgatataca aagcgagcac cataaagaaa 2398501 gcgggcagat tgccagccaa aaagctcgca cccagcacat taagcgcaat cgtcccaggg 2398561 atgattccca cagccgttgc ggcaaaatac ggcagcgctt tgacattgga aaggcctgcc 2398621 gcatagctga cgaaatcaaa attgatcggc aggattctca aaagaaagat atagaaaaat 2398681 ccgttatcct ccatttgctt ctgtatggct tcaagccttt cgtaatgccc gttctttttc 2398741 gccgaaaaca aaccagccgc aaaaaacgaa acagctgaag cgcacatcga accgaataac 2398801 gtataaagcg tgccgagaag cgggccaaac gcaagtccgc cagctattga aataacagac 2398861 accggaaata aaacaagtgg cctgacgatg gatatcccga taaacatcag aggtgcaaag 2398921 actccgaacg acaataccca taccctgatt tctttcggcg atacattcaa atacgtttta 2398981 tttccccaat agagtaaacc agcacctgca agcactgcca gccatttgac agccgttttt 2399041 cgtttcatac cctcagttcc ttcccctttg aaccacagca attatggatg tcggcggttt 2399101 tctccgtcaa ggcggatcgg agcagccaaa tataatatcc gctccattaa tcttgcagct 2399161 tttacttctt ctttttctcc cctctgcgaa tacgtaaaat gatgcttcag ctcgtcaggt 2399221 gagaaattag aagaaaagaa cgttggcagc tgctgggaca ttctgtgctg aagcaccgtt 2399281 ccgatgacct catcccttac ccagcttgtc attgattctg ctccgatgtc atcaagcatt 2399341 aatacgggtg tggtctttac catattgagc ttctcttcca atgtctggtc ttgcagcgaa 2399401 ttcttaagct ctctcacaaa ttcaggcaca taaacaatca tggaggaata ctctttttcc 2399461 gccagctcat tggcaattgc agcgagcata aacgtttttc ctaccccaaa tttcccgtat 2399521 aaatataatc ctttcccttt tcccgtctca ttatagcttt tcaggaagtc tgtaacatgc 2399581 tgaaacatcg cgagtctgct tgggtcactg atatcaactt gctggaacgt cgctccaaga 2399641 agatcctgct ggatatacat gcttttcata agagactgtt gtttcttctg ctggtcgagc 2399701 ttccgtttga ctggacattc gtaatactcg atatcaatag acctcccatt gacaacaagc 2399761 ttcggatggt agccctccaa caaattgttg cagttttcat cttccgaaca ataggagcaa 2399821 ttcttgcttt gttcgatata ttcataaagc ttatttaagc tcttttcgat cattttttgg 2399881 tcaatcactt cttcgttttc cttcaaaaat gcttgaacat cttgatcttt catgactttt 2399941 tccttcattt gttcaagacg tttttggaaa tccggcctgc cggttacgcc ctgcagggaa 2400001 cggccgattg gttccatcta ttccttcacc ccgcatctct gtctttaata ggcagagtat 2400061 tttttcagtt tttgcatttc ttccatcatc tttttcttct gttcttccaa atcctgcgga 2400121 tgcagcttct gctgtccgga ttctgaatcg gacgctgttt ccttttctgt catccaatca 2400181 ggaagctttt cttcacgaat cactttttgg tttcgtttcg aagactttgt ttttccctca 2400241 gcccattcaa gatactggcg gttttcttct attgcgagct tcatcgcttc cctgaccgtt 2400301 ttcacctttt tgcgtgccca atgcgaagcg attttttgga tatagttttt cgacagcttc 2400361 atgtcggttt tcagcatgac ataataaatt aacacatttg tgacgcctgg ctcgagcttc 2400421 tgttcgaaca taatttcttc tatgatcttc agatcagctt ttgacggctc tgttccgtca 2400481 gcaatgtcct gcagaagctt cttcggggaa atcgcctcca gcaatgcaat cagcttccca 2400541 tccagagaat cctcttctgc cggttgttcg ccttcacgca gatgcaccgg ctgtgttttt 2400601 tccaccaaat cgggcagctg tccgtttctt tcaatttgat accagtcgct cgccgctttt 2400661 cttaatgcct ccgtcgtaat gacgtcacgc tcatcaattg cgctcatcac aacattttgc 2400721 atttgcaaag ggtcaattcc gtacagataa gaaagctttt tgattgtgtc ccgcacctgc 2400781 tgggtcatcg cttttctcgg tatcatcgtc tcagaaagtc ccgctaaaaa caaatcaaaa 2400841 tcaaacacat cctccgttat ggtgtaggac ggagactgtc cgacagaagt atactcggac 2400901 ccctcggcaa gccttaccgt ttcctccata tcggatgtga gcttccattc actcggctgc 2400961 agcgattcaa acgcatgatt aaacggacgc gtaatgtcct tcgcatcttc tgaaatggcc 2401021 gggtgcgtaa aaaattgttt taattgctga tatttcgttt ttccgaccct attatacaga 2401081 aaaacattca gcattccgtc ttcaaaaaat tcatttggtc tgagcggcgg aaggagttca 2401141 tatataaaga ggcgctcctg ccgctcggat tctttcatat atactttcag caatccgatg 2401201 ccctcgagct tcccctgttc ctgatggatc gtttttaagt tggactgtgt catccccatc 2401261 agctgtctat gtgtggactc tccgccccac agacggtttt gttcaagctc tccccacaat 2401321 gtcatataaa gagagaatgc aacagggccg attaagggct ggtacagttg tgtaataatt 2401381 tgtctgtcaa tatcctgcag catcgatctg cttttaacca catacgggtc tacaggcagt 2401441 acatctttcc aatagtcagc catacattct caaaccttcc gaatttgttt ctacctttca 2401501 ttttacaccg tttcttatat ctatcaaatg ccaattttgc acatgagaaa agagctagaa 2401561 gaatcctctt agctctttta acgctctttc tttattaagt cttttaattc atcgataaag 2401621 acgtttatat ctttaaactg ccgatagacg gacgcgaacc gcacatatgc gacttcgtca 2401681 atcttagcca gccggtccat gaccatttct ccgacgagct cactcttcac ctcggagcag 2401741 ccttgattgc gaagttcttt ttcaatatca aagcacatgt cttcaagcgt tttgagtgaa 2401801 acaggccttt tttcacatgc ttttatgagg ccgcgcagca ttttttctct gctgaattcc 2401861 tcacgcacac cttctttttt cacaacgatg agcggggttt cctccacttt ctcaaaggtc 2401921 gtaaaccggt agtggcagga ttcgcactcg cgtcttcggc gaatcgactt tccgtcatcc 2401981 acaggccgtg aatcaaggac tcgtgttccg ttatgctggc atgaaggaca tttcaataaa 2402041 atcagctccc aactatatcg ttccctgcaa tgtattttcg gcagcctccg ccttttaaaa 2402101 atagatgtga cagcatctgt cgggagagcc gttgttaaat ttgtttctat agcattaggt 2402161 ggtttgtgaa aatctccttc ttattttaca aaaaaaatga aaaaagaaaa agctgacact 2402221 ctcgtttctt tataaaaata aaaggagcat aagctaaaaa gcgcataatg gctttctagc 2402281 ttcagctccc tttgtgttcg caatttactt tatagtactt tcgcttgcgc ctgtttaatt 2402341 tgcacaggcc ccattcctct tggtatttca atgttttctc ttgtatcagc atgtaatgcc 2402401 tctgcaatgt aatcagcagc gacattagga tctaagtctc cacaagtata aacatcaatg 2402461 ctcgcatatc cgtgctcagg aaaactgtga atcgttaagt gtgattcaga aataatcaca 2402521 actccgctta cgccttgcgg tgcaaatttg tgaaatgcaa cctcgcgcac ctcagcacct 2402581 gattttagag cagcatttac aaacgttttt tcaataaaat ccatgtcatt cagcttatca 2402641 aaatcgcatc cccatagctc ggagataacg tgacgcccca ttgtttccat agtcatggac 2402701 cccccttaac aagaattaaa aagtgaaatt ccaacaactg ggtcggccat ttaccacggg 2402761 ggaaagttag tccggagagg tcctaaccct ttaagtaatt ccgaaacagt ctcaagcaag 2402821 aagttcacga aaaatagtat actgtgttta agtctaattt gcaaggtgcg ttttttcaga 2402881 aatatgctgt taagggtttt ttctttaaaa tgtgtccatg accttatttt atacagcaga 2402941 cggatgtttc attcgtgccg ctacatggcg gattagatca acaactctgc aggagtagcc 2403001 ccattcgttg tcataccacg ccagcacctt tactttcctg tcttccatta ccattgttgt 2403061 aagcccgtca atgaccgctg aatgcggatt cgtattataa tcagtcgaaa cgagcggttc 2403121 atctgagtaa tcaagtacac cgtacatcga cgttttggca gcgcgtttaa atgcctcgtt 2403181 tacttcttca gccgtaacat ccgttttcag atcaacaacg agatcaacca atgagacgtt 2403241 cggaacaggg acacgcaagg cgaggccgtg aagttttcct ttcagatgcg gcagcacaag 2403301 cgaaagcgcc tttgccgctc ctgttgttgt tggaatgatg gattcaccgc aagcccgcgc 2403361 ccggcgcaaa tctttgtgcg ggttatcaat atttttttgg tcattcgtat acgcatgaac 2403421 tgtagtcatc agaccgctct caatgccaaa ctcttcatcc agcactttta caacaggcgc 2403481 aaggcaattt gtcgtgcatg acgcatttga aataatgaca tggcgctcag cgtcgaattg 2403541 gtcctcattt acgcccatca caatggtaac gtcttcattt tttcccggag cggtcaaaat 2403601 cacttttttt gcacctgctt ctatatggcc catcgcttta tctttagcat taaacttccc 2403661 tgttgcttcg acgactatgt caatatcata ttcccgccaa ggcagctgtt ttggatcacg 2403721 gctgtttaac aaaagcactt tctttccatt tacgatcagg ctatcttcac cagccacaac 2403781 ctctttgtcg tatctgccgt gaattgtgtc atactttatt aaatgagcca gcgtttctgc 2403841 ggaatagctg gcgttaatgg ccactacttg aatttgatcg tctaacatcg cttttctaaa 2403901 aaccattctt ccgattcttc caaacccgtt gatcgctact tttaccttca tgttggacac 2403961 cccttatcaa ttatgccatc ctaatttgtt actatctaaa attagtataa cacattaaaa 2404021 caaattcgcc agtacatatt gataaaaatc aacgattata acgctaattt atgatgcatc 2404081 ttatgttttc ttgcacagaa tatcaggcgt aagaaccaaa aagcagccag cgctccgcac 2404141 tgactgccct catgctttat gattcctgtt ttaacttatc attgagcaca ctttcttcta 2404201 gcacagaaaa tgtatccccg tacactctgt taatatgatt cgctccccaa gcacacagca 2404261 tatctaaaat cccttctaag ctgcggccgt attcgctgag ctcgtattcc actttgggag 2404321 gaacttgatt atatacgatt cggttaatga caccgtccgc ttccagctcg cgcagctgct 2404381 gagtcagcat tttttgcgtg atattgggca ttaggcgttt taattcactt gtgcgttttt 2404441 ttccgtgcgt cagatggcat aaaatgacgc atttccattt cccaccgatc acttcaagag 2404501 tcgcttcaac agaaatgtta tattttttct tctccataca atccattctc ctcacaggca 2404561 ccaaaaagtg actatagcac ttcaaagtac gtacttttat ttcttaacga tatgtttcat 2404621 aatcacattt gccggctgat ttgaatctgc tcttttttat ttatatagct tactcggcag 2404681 aatttcaatc atacaacaca tcttacaaag gaggaacatc atgacttcag ccaataaaag 2404741 caatattcct gcactactgg ctttggccgt aagtgcattc gcaataggga caactgaatt 2404801 tatcagtgtc ggccttttgc cgctcattgc tgatgacctg gatattcccg tcacgacagc 2404861 aggattgacc gtttcccttt atgcgctcgg cgttacattt ggggcaccta tattaacttc 2404921 attgacctca agcatgtcac gtaagacact attgctttgg atcatgttta tttttattgc 2404981 cggtaatacg atggcagcaa ccgcttcaag catcgggatt ttactagcag cacgtgtgat 2405041 atcggcattt tcgcacggtg tgtttatgtc gatcggttcg acaatcgcag cggatattgt 2405101 cccggaggat aaaagggcta gcgcgatttc aattatgttt actggcctca ctgtggcaac 2405161 tgtaaccgga gttccttttg ggacatttat cggccagcag ttcggctggc gtttcgcctt 2405221 tatggtcatt atcgccgtcg gaatcattgc tttcattaca aatggcattc ttgtaccgtc 2405281 caaattacga aaagggacga aaacaacgat gcgggatcaa ttgaagcttg tgacaaacag 2405341 ccggttattg cttttatttg tcattacagc gcttggatac ggaggaacat tcgttgtgtt 2405401 cacgtatctg tctcccctgc ttcaggaagt aacaggcttc aaagccggga ctgttgcagt 2405461 gattctgctc ggatacggaa tagctattgc tatcggcaat atgattggcg gaaagctgtc 2405521 aaaccgaaat ccgattgccg ctttattcta tatgtttatc gtacaggcaa tcgttctatt 2405581 cgtactgaca tttacagccc cgtatcaagc agcagggctc attaccattc tctgtatggg 2405641 attgctggcc tttatgaacg tgcccggcct tcaggtgtat gtcgtcatgc tggctgagcg 2405701 ttttgtcccg agtgcagttg acgtcgcatc cgcgatgaat atcgctgcct ttaatgcagg 2405761 gatcgcgctt gggtcatacc ttggcggtgt gatcaccgat tcaatcggat tgattcatac 2405821 cgcttggata ggcggattaa tggtggtcgg tgcagtcatt ttaacaggct ggagccgctt 2405881 gatggaaaaa cgagatcggc aggaagcctg acaattttaa aggaggaaat aaacatgaca 2405941 acacatttac aagcaaaagc aacacttcat aatggggtag aaatgccttg gttcggcctc 2406001 ggcgtgttcc aagtggaaga aggatctgaa ctggtaaacg cagttaaaac tgccattgtt 2406061 cacgggtacc gcagtattga tactgcagca atctatggaa atgaagctgg agtcggagaa 2406121 gggattcggg aaggcattga agaagcaggc atttcaagag aggatctgtt tatcacatcg 2406181 aaagtatgga atgcggattt aggctacgaa gaaacactcg ccgcgtttga aacaagtctg 2406241 tccaaactcg gtctggatta tttggatcta tacctcatcc actggcctgt agaaggaaag 2406301 tataaagaag cttggagagc gcttgaaacg ctgtataaag aaggccgtat caaagcgatt 2406361 ggcgtaagca acttccaaat tcaccatctt gaagatctga tgacggcagc tgaaattaag 2406421 cctatgatta accaagtgga atttcacccg cgcctcacac aaaaagagtt gataagatac 2406481 tgccaaaatc agggcatcca gatggaggct tggtcacctt taatgcaggg acagctgctg 2406541 gatcaccctg tattggctga catcgctcaa acatataata aatctgtcgc acaaattatt 2406601 ttgcgctggg atctgcagca tggcattata acgattccta aatcaacgaa ggaacaccgc 2406661 attaaagaaa atgcaagcgt atttgacttt gaattaacgc aggatgacat gaaccgaatc 2406721 gatgcactga atgaaaactt gcgcgtcggt cctgatccgg acaactttga tttttaatgg 2406781 ccaaaaaaca ccgttcaata tgaacggtgt tttttgtatt atgcccagct gttcatgatt 2406841 tcatcaagct gccttttggt ctcttcaagc gtgccgctgt tatcaatgac ttgatctgct 2406901 cttgctgttt tttcctctaa gggcatttga gagcggatac ggctgactgc ttcttcttct 2406961 gtcagctgat tgcgcttcat cagacgttcc agttgaagct cttttgtcac actgaccaca 2407021 ataattttat caaccaatga ttccaatttg ctttcgaaca atagcgggat atccaataca 2407081 acaaatgcct cccgatttgc aacggcttca tcacggcgat tgagcatttc ctgcctgact 2407141 gcgggatgaa caattgcatt taaagcgaga cgtttttgtt catttgtaaa taccagcgct 2407201 ccaagctttt ttctatctat atcgccattt gagagcagta tgtcttcacc gaattcgtca 2407261 atgatttgcc ggtaggccgg catccctttt tctaccgctt gttttgcaat gatatctgca 2407321 tctataactg ttattccttt ttcaatcagc atattggcta ccgtgctttt gccgctagct 2407381 attcctcccg ttaaaccaat gactaaggtc aagagatcca ctccttttta caatttccag 2407441 agcccaatcg tgattaatag aagccccggc aaaaacgcca ttttatcgat ccatttccac 2407501 ttagacagaa aatggccggc attgattcca attgatacaa acagcgagct catgattgcc 2407561 acggcgatgc tcatcacaat cggcgaaaaa ccgagaatgg ctgcgcctat acctgctcca 2407621 aaggcatcaa tcgataaggc aaatcccaat aagaccgcct caattccgtt gatcacaccc 2407681 gatttgtcga tatccgcact catgggtttt ctcaaaatat gaatcacaat tcctaatgac 2407741 cgaacctcta gattaagcag tgttttttca tgcaataggt attctttatc ttttgccggt 2407801 ttgaaaaatt gatacagaac ccacgcaccg attccaacca atatcaaacc gccaagcttc 2407861 tccgtcacat atacaggaaa aaacttcgtg agaaagcttc cgatcagcat ggatataaac 2407921 atgacagcac cggaacagca ggcgataacc aaaatcgctt taaacggtat tttcattttt 2407981 ctcaatccgt acgtaaatcc gactgaaaaa ctgtccaagc tgacagccaa cgccagcagc 2408041 agtatagaaa ccatttgcat atccgtttct tcctttctgt tggtgctctt gtatcagatg 2408101 tgaaatgccc gggattcatc acaatcatat atatgggaaa gtgaaaaatc cgtgtttcga 2408161 aaatggcatc cttaatccag agttactgat atatgcaccg acagcttgga caatgaagca 2408221 ttatgctact tttttgtctg gcactttgcg caaaaatgcg tgcctcttcc tccaacgaca 2408281 attttcgaaa tcatcgttcc gcaatttttg catggctcgt ctttttttcc gtacacaaaa 2408341 tgctgcagct ggaacattcc gatttcccct tgggagttga tatatgaacg gactgtgctt 2408401 ccgcccgcat caatcgcctc ctgcagagtg tttttgattt cagcgtgaag ggttttgatt 2408461 gttttatctg ataattgatt tgcttttgtc tcgggatgga cacccgctct gaaaagagcc 2408521 tcatccacat aaatgttccc gagtccaact accgtttttt gatccagtag ggcagttttg 2408581 acagcgcggt ttgttttcgc aagccggtct tttaaatacg cacttgtaaa ttcttctgca 2408641 tccggctccg gccctaactg agaaagcggg agctcgcccg cttcttctcc cggtttaaat 2408701 aagtgcatgg ttccaaattt ccgcacatcc ctgtaccgga gctgggttcc atccgtcatc 2408761 gtgaatatga catgcacgtg tttatcgtca ggctcctcgg cttgatgaag accgtatttt 2408821 ccttccattc gaaggtgaga aaccataaca taatgatcta aatgaaacag taaaaacttt 2408881 ccccgtcttc cgatggactg tatcgtttct cctgctagtt ttcgcgcaaa ttcctccggt 2408941 tcggcaggcc gtttgatgat attcggccat ctgatctcta ccgatttgat tgtttttccc 2409001 tttacaagcc cggtcagagt gcgccggacc gtctcaacct ctggtaattc cggcacatcc 2409061 atcacttcct atctctgttt atttcgcatc gtaccaagat gggcctgatg caaagtccac 2409121 ctttaacggc acatctaatg caagcgcatg ctccatcact tcaggaacaa gcttttcaag 2409181 aatttcaatt tcttcctttg gcgcctcaaa aatcaattca tcgtgtactt gaagcagaag 2409241 ccttgctttc aactgttttt ctttcagctt ggcagccatg tcaatcatgg cttttttgat 2409301 aatatcagcg gcgcttcctt gaatcggcgt attcatggcc gtccgctccg caaaacttcg 2409361 gatattaaag ttccggctcg tcagctcagg gatgtagcgg cggcgatgca taagcgttgt 2409421 tacgtatcct ttttgtttcg cttcctgtac tgaatcttcc atgtacgctt ttacgccttg 2409481 gaagctttcc agatagcggt cgataaatgc tcccgcttcc ttccgggtaa tgccgaggtt 2409541 ctgtgacaga ccgtaatcgc tgatcccgta aacaatgcca aagttgaccg ctttcgcctg 2409601 gcgtctcatc gcagatgtca cttcatcctt agcgacatgg aacacatcca ttgccgtttt 2409661 cgtgtgaata tccatatcat tagtaaaagc ttcgatcaga ttttcatcct ttgaaatatg 2409721 ggcaagcacc cgcagctcga tttgtgaata atcggctgca aaaatgagcc agtctttttc 2409781 agacggcaca aaagcttggc gaattttccg cccttcctca agcctgatcg gaatgttttg 2409841 caggttcgga tcagtcgagc tgagacggcc agtttgcgtt aaggcctggt taaatcgcgt 2409901 gtgcacttta tgcgaatccg gtctcgtcac ctttaaaagc ccttcgatat atgttgattg 2409961 aagcttgcca atttgtctgt actgtaaaat atagtcgaca atatcatgct tgtcagccag 2410021 cttttcaagc acatcggcag acgtagaata gcctgttttc gttttcttta cgacaggaag 2410081 gccgatcttt tcaaataaga tgacgcctag ctgtttcgga gaattgatgt taaacggctc 2410141 tcccgcaatc tcatggattt tttcttcata ttccttcagc ttcgcaccca gttcttcacc 2410201 catccgtttt aaacggtcaa catcgacctt gacgccagtt gattccattt cgccaagaat 2410261 aagcgcaaga ggcatttcca gctcttcaaa cagttcaagc tggtcgttgt tttccagctc 2410321 ttgaacgagc ttttcccgaa ggctttgaat cgctaacgct tttcggccaa ggtgctcaga 2410381 cagtacgtct tctgacggca ctgcccgttt tgctcctttt ccataaactg attcatcact 2410441 tgaaacgata tgcaggccgt aatccttagc cacactcgca acgtcgtcat atgaattgcc 2410501 cgggttgatg atataagccg caaggagcgt atcaaactcg gctcctttca gctcaatgcc 2410561 ctgccagcgc aaagcgacaa cggcccgctt gctgtcgaag acccatttct tctgctcgtc 2410621 attttccacc cattctttaa acacctcaga ctcaacggca atgtctttcg gaatgaaata 2410681 agctcccgtt tcatttacga tcgaaaatcc gaggatcggc tcttcatgat aattatcgcc 2410741 aatctgttca acgacaaatg cggatggaga aaccaatata tcgcttgtca cgtctgtgac 2410801 tgttttgaca ttaatgtctt ccaacgattg atcctgttct gcttctgcac tgtcttctcc 2410861 aagccgttca agaagcgtgt tgaagccaag atctttaaag atggcaatga cctgttcacg 2410921 attaaagcct tgatattcca ggccggaaac agatacctca atcggagcat ccgtcataat 2410981 tgtcgcaagc tccttgctca tcaatgcctg atccttaaac tcctcaagct tttccttcaa 2411041 tttctttccg ctcacctcgt caatggactc cagcagcttt tcaacggaat caaattgttt 2411101 taaaagctta atcgcagtct tttctccgac gccgggcaca cccggaatat tatctgagga 2411161 atcgcccatc agacccttca tgtcaatgat ttgttcaggc gtaagcccat atttctcttt 2411221 gacatgctcc ggtgtgtaaa attcaacatc ggtaattccc tttctcgtaa tggcaactgt 2411281 cgttttgtcc gttgccagct gggttaaatc cttatctcct gagaaaacct taacttcaaa 2411341 tccgtctttt tcagccgatt tggccagtgt gccgataata tcatccgctt catattgttc 2411401 cagttcatag cggctgatct ggtaggcatc cagcagctcg cggataaacg gcatttgttc 2411461 ggaaagctca ggcggggttt tctgtctgcc gcctttatat tctttaaatg tgccgtgacg 2411521 aaatgttgtt ttcccggcat caaacgcaac cagcatgtgc gtcggttttt catcctcaag 2411581 cattttcatc aaaatcatcg caaagccgta tacagcattc gtatgaacac ctttatcatt 2411641 gcttaacagc ggcaatgcaa aaaacgcccg gtaagccaga ctgtttccgt ctacaagcac 2411701 taattttttt cgttccgtca ttcaatttcc tcctaagaag cctcaggctt ccattcatct 2411761 cttacatagt cattagctcc tcttatttta acaaagttca atttgaaagg aaaatacgtg 2411821 aactataaga gaagacacaa aaaaggacgg gaacacaaat aggttcccgc cgtcaaaatt 2411881 ggctccttgg atgaaggggt tctactacat cctaccagca taggtttaac agtgcatgaa 2411941 gatattgtta aacctttgta aacattaggc ggacttttca gcggcccgtt tcagcgtcac 2412001 ggtaaagaca gttccccgtc caagctcgct tgtgacatca attttccctt catgagcctc 2412061 tattaaatgc ttgacaatcg ctaggcccag cccggttccg cccgaatttc tgcttctgtc 2412121 tttatctaca cggtaaaagc gttcaaagat gcgcggaatt tcttctttct gaattccgat 2412181 tccagaatcg gcaacctcaa tctgaatgtc tttttctctg ggctttacat tgatagccac 2412241 ggagcccccc tcaggcgtgt aggttaatgc attgtttacg agattaagaa atacctgttt 2412301 cagcctgtac gggtcaccag atacatattg agggtctttc gggacattca ggtgcaagga 2412361 gatgcctttc tcatccgcct tatgcttcag aagcgtttca atctcaccaa gcattttggc 2412421 cggctcaaac gtttcgatac tgagcgtgaa attttgctgc tcgatttttg agagatcgag 2412481 caaatcctga accaaagact gaagcctttc gctttcctta agaataatag agagaaattc 2412541 agaaagcgcc tctttgtctt ccatcgcccc gtccaataac gtctccgtaa acccttttat 2412601 ggacgtaatc ggtgttttca gctcatgaga aacattggcc acaaaatcct tcctcatctg 2412661 ctctaatttc ttcgtttccg tcatgtcatg gaaaacgagc acaattcctt tccattcatc 2412721 gtccggcccc ataatcggaa cgccgtccac ttcaaaataa cgccgttcta ttttgatcgg 2412781 cagtcttaac agcttgcatt tctttgtctc cgtcataaaa atgtcttcga caagctggat 2412841 cacttcttca tgttcaaatg catcgtgata aagacggcgc agcatatgat tcggattgat 2412901 atgaaactgc ttggcgtaag acctgtttac gagattaata aagcctcttc cgtcgatcat 2412961 aatcagcccg gagccaatgt tttcaatgac tgtcagcagc cgatcccgct gcatttcctg 2413021 cgttcgcgtc atttccatca gatcaatggc aaggctgttc atcgcatgtc ctagcttatc 2413081 agaacgccta atatagccgc cgtacgtccg tgcatcgtag ttgcccttag agagttctgt 2413141 ggctacattt gtcgctgact caattgacct tttataacgt gaggtcatgc tggaataaaa 2413201 ataaacaatg acgataaatg cggtacaaag actggccgtc agcatccccc acaattcgcc 2413261 ttttaagccg tcgctttttt cagaggcgga aagcagcaca tatcctgttt tttcaccttc 2413321 gcttctaagt gaaagtccgt aataaagctt gttatctgtt gttgacagaa taccctcatg 2413381 gccagaaaca agcgcctgca ccttttggga atcagccgat ctaccgtttg acccatacag 2413441 caccttaccg tctgtatcga taacggatgc gctcacatca agcgcgccgc ctgcatcttt 2413501 aatgattttc tcatttgctt gattattcag attgccggca tcaagaagcg aagccaagta 2413561 ttttgcttct ttttcaatgt gttcctctgc tttcctttga tcagatgttt caaaaagctg 2413621 ctgtaaaaac agcccgagga cacaaaacac cagaatcata cagacaacga atacagaaaa 2413681 aaggcgcaca cggtatttat tcattcattt ttggctcctc cagtttatac cccaatcccc 2413741 taatcgtttt aatgtagatc ggttttttgg tattgttttc aattttgtcg cgaagatggc 2413801 tgatgtgcac atcaacaatt ctcgtatctc cggcaaaatc ataattccag actgcgctca 2413861 gcagcaggtc tcttgtcaga actctgcctt tatgtctgcc taaatagagc agcagttcga 2413921 attctttcgg tgtcagttca agctgacttt ctttaaagta cgcttcataa tgatcaggca 2413981 ggattttcag atcgccgatt acgatctggc cttccatttc atcgttcttc atctcactag 2414041 agggcgcagc tatttccgaa cgccttaaaa tcgctttgac tctcgcattt acttcccttg 2414101 gactgaacgg cttggtcata taatcatcag caccgagctc cagccctaat actttgtcga 2414161 attcctcatc cttcgctgtc agcattaaaa tgggaaacat cagtttttgc tgtctcagct 2414221 gcttgcatac ttcgattccg tccaattttg gaagcatcac atcaagcaca atcaaatcag 2414281 gtttctctgt ttccgctttt ttgagtgctt cttccccatc cgaggcggta atgacatcat 2414341 agcctgaccg ttccaaattg tactgtaaaa gagtaacaat agattcttca tcatccacaa 2414401 ctaaaatttt cttgttcatg ctgtgcctcc agtattataa ttccccgaca tcctatttct 2414461 ctattttatg tcatcttaac atgtttcatg attttatttt agcgaaagca ggacattccg 2414521 acaattcgcc ttttacatca tttttaaaag aaataaagac gtttatgata gcgctttcat 2414581 ttatagtaaa aagagaaagg ctgtattaag caagcctttc tctcttttta ttaggataat 2414641 actttcatga catttttgac agattcaact gatttattca gctgcgctct ttcatagtct 2414701 gtcagttcaa gttcaatgat ttgctcaaga ccgttgccgc ctacaattgt aggaacacca 2414761 aggtagatgc cttcatagcc gtattcccct tcaagataag caattgtagg aaggacgcgg 2414821 cgctgatctt tcaagatcgc ttcgaccatt tctgtcagag aagccgcagg cgcataatac 2414881 gcgcttccgt ttccaagaag attcacgatt tcgcctccgc cttttctagt gcgctccaca 2414941 attgcgtcaa tccgttcttt cggaataaga gtttcaagcg ggataccgcc agcataagaa 2415001 taacgcacaa gcggaaccat atcgtcaccg tgtccgccga gtacgaaacc agtcacatct 2415061 ttcactgaca ggtttaattc ctctgccaca aatgttctga atcttgccgt atcaagcaca 2415121 cctgactggc cgattacacg ctctttaggg aagcctgatt ctttgtacac cgcgtatgtc 2415181 attgcatcaa caggatttgt cagcaccaca ataatagagt caggagaata tttcacgatt 2415241 tcctgcgtaa cgcttctcat aatcttttcg tttgtagaga ccagatcatc tctgctcata 2415301 ccaggttttc ttgcgatacc ggctgtaatg acaacaatgt cagagccggc tgtatcctcg 2415361 taattggatg ttcccgtaat ttttgcgtca aagccttgaa ccgggcttgc ttcaagcata 2415421 tcaagcgctt ttccctttgt cgggttctcc aattgcggaa tgtcaacaag aacaacgtct 2415481 gccagctctt tttgagcgat taaaaatgca gttgtagctc cggtaaaacc tgctccgata 2415541 acagaaactt ttttacgagt atttcccatg tctctcttct cctttatggc tagttttagg 2415601 ctttttcctt gcttagtcca tgtttttgat cagttcttct ccgaactctg aacatttcac 2415661 ttcagtcgcc ccgtccatta atctggcaaa atcgtaagtt acgactttag aagcgattgt 2415721 tttttccata gatttgataa ccaaatcagc cgcttcgttc catcctaaat gctcaagaag 2415781 cagaacgcct gaaagaataa ctgaagatgg gtttacttta tcaaggcctg catatttagg 2415841 agccgttccg tgcgtcgcct cgaaaatcgc atgtcctgtt tcgtagttga tgttcgctcc 2415901 aggagcaatg ccgattccgc cgacttgcgc agcaagagca tcagaaatgt aatctccgtt 2415961 caagttcatt gtcgcaacga catcaaactc gtttggacgc gttaagatct gctgaaggaa 2416021 aatgtcagca atgctgtctt tgataatgat ttttcctgct gcttccgctt cgctttgcgc 2416081 tttgttggca gcgtcttttc cttgttcttc agcaatgcgg tcatattgag cccatgtgaa 2416141 gactttatct ccgtattctt tttcagcaag ttcatagccc cagtttttga aggcgccttc 2416201 tgtgaacttc atgatgtttc ctttgtgaac aagtgttaca gatttgcggc catgctcgat 2416261 cgcataatca atggcagctc tgaccaagcg gcttgttcct tcttctgaaa caggcttaat 2416321 gccgatacct gatgtctcag ggaaacggat tttattgacg tttaactcat tttgaaggaa 2416381 gctgataagc ttttgcactt cttcagagcc ttttgcatac tcgatgcctg cgtaaatatc 2416441 ttctgtattt tcacggaaga tgaccatatc agtatcttca gggcgtttta ccggtgacgg 2416501 cactccagta aagtatctta caggtcttaa gcagacgaat aggtcaagct cttgtctgag 2416561 cgctacgttc aaagaacgga taccgccgcc gacaggtgtc gttaacgggc ctttaatcgc 2416621 gatgaaatat tcgcggatca catctaatgt ttcagcaggg agccactcac ctgttttatt 2416681 ataagccttt tctccggcgt aaacttcttt ccatgtaatt ttcttttcgc ctttgtatgc 2416741 tttttctact gctgcttcca aaaccttcga agccgcgttc caaatatcag gaccggttcc 2416801 gtctccttcg ataaatggga taatcgggtt gtttggtacg tttaatactc cgttagagac 2416861 tgtaattttt tcaccttgtg ccacaataaa aacctcccag tatgtaattc atatttagaa 2416921 aacattttat ttttcttata tagaaaataa aatgattttt cctaacattc aatttaaagt 2416981 gtaacccaat tttgatgtct gaacaagagg ctaacctcat tgacgcaagc cagcctccaa 2417041 tggttcttta ggctctttct tcaatcggaa cgaatttttg tttgtcaggg cctgtgtaat 2417101 ctgcccgcgg gcggatcaga cggttgttgt catactgctc aagaatatga gcgagccagc 2417161 cggacattct gcttacagca aaaatcggtg taaacaaatc atggtcaata ccgaggctgt 2417221 gatatacaga agccgaatag aaatcaacgt taggcggaag ctttttctct gatgtgacga 2417281 tgtcttctat acgaatcgac atctcatacc atttgctttc gcctgtcagg ttggtcaggc 2417341 gcttgctcat ttctttcaga tgcttcgcgc gcggatcacc atgcttatac acacggtggc 2417401 cgaatcccat gattttttct ttcttttcaa gtttagcgcg gatgtacggc tcagcgtttt 2417461 ccacttcacc gatttctgtc agcattttca taacgccttc attcgctccg ccgtgaagag 2417521 gccctttcag cgcgccgatt gctgcagtaa tgcctgaata gatgtcagaa agtgttgcga 2417581 cgcagaccct cgctgtgaac gttgacgcgt tcagctcatg gtcagcatgt aaaatcaatg 2417641 ctttgttgaa ggcttcaact tcaattggtg aaggctcttc accgtttaat gtgtaaagaa 2417701 aattctccgc aataccgtaa tcttctctcg gttcaacagg ctcaagaccc ttgcgaattc 2417761 tggaaaacgc tgcaaccagg ccaggcacct ttgcctgaag gcggatcgcc tttctgtagt 2417821 tggcttccgg gttcatggta tcagcctcgc tgtcaagcag gcctagtaat gaaattgctg 2417881 tccgaagagc agccatggga tgaacatttt cgagggaata agatttgaag tgctcaataa 2417941 tttcttgcgg aacggcagct tcctttgcaa gctgctgctt taactcttca agctcttttt 2418001 tgtttggcag ccttagatgc caaagcaagt agatgatttc ttcaaaactt gcattctctg 2418061 tcaaatcatc gatatcatac cccacatatg taagggtatc atcaataata gaactaacag 2418121 atgatgttgt tgctacaacc ccttcaagac cgcgtgtcgc tgtcatatat aacatctcct 2418181 tttcaataaa tttccccttt aagagtgttg taaaaacatg aggcttactt aaaaagcacg 2418241 atgcaagtat ttctctcccc caaaaagaaa atgcttacat tttactggct gctggaacta 2418301 aaaccctttg cttttgaaag aacataacaa atttttataa gcttatttaa gtttaagcct 2418361 attctcatta taaacaataa tcagacattt gttaaatgtt tacctataat tttttttttc 2418421 cattctgtga tttccccgaa aaaacgcctt tatttgcggg tttttgcata aaaaaaagcg 2418481 gctttaaggc cgcttttttt tatgaagtga acagttttac gatctgcatg gctaaataag 2418541 caatccccgc tccgatcagc ggccccaccg caactcctcc aaaaagcgcg actgcaagaa 2418601 tggtcccgat cacgagagca gttgtaatat gcggatcatt ttcaagcagg gtcaggccgt 2418661 tttttgcaat cagcgccact gcgatccccg ctccaagggc gatccatgcg taggaagacc 2418721 gcattgcttc tccaagctgc ttaaatccga tttctcccgt ggcaatcggg acaagaacgg 2418781 cgatggtaat aatggtcaca ccccagttaa tgccttttga ctggatggtc ggaaataatt 2418841 tctgatcaag cccaacgatt ttgatgatca aaaggacgga tacagcaaag agcaatgatt 2418901 ggttttttgc gataagtgcg atagccaaga gtaaaattaa aaataaattc gcttgtgtaa 2418961 acacatgcca tccctccttt aagatgaatg tattcatatt cagccgcagc gtgaatacat 2419021 ataaaaaata ggacatgctg acgagaggag gaccgttttt gtgaatcaat cttatatcac 2419081 tatttttttc agaaccctct ttgtcatatc aatgaccgca gggtcgatag ctgcggccta 2419141 ttattcgttt ccgttaactt atccgttcct gatcgccctt attctatctt cagtgattca 2419201 tcctgttgtc gattatttgg acaaagtgac aggattcccc cgaacgataa atgttctggg 2419261 cgttcttgct ttttttctgc tcgcagcctt cggcgtgctc accattctgg tagccgaaat 2419321 cgtaacggga acagcctatc tagcaaaaac gctgcctccg catatcagca cgtttatttc 2419381 atattgcgaa aaattgttta ccactcatat tcagccgctc tataacgagt taactctttt 2419441 gtttcaagaa ttggaaacga accagcaggc ttccatcgtc actcatatcc agacactcgg 2419501 tgattctgcc gctaaaaatg ccgggctcct gctgtcccac attctagaga tgatcccgag 2419561 atttttcgct cttcttccca atacggcggc ggttctgatt ttttctcttc tggcaacctt 2419621 ttttatgaca aaggattggc ataagctgaa agccatgctt gttttaattc tgccggatcg 2419681 tgtgacagct aacagcaaag caatcagcag cgaattaaaa aaagcaatga ctggttttat 2419741 caaagcacaa gccgtcctcg ttttcatcac gatggtgatt gtatttatcg gcctttctct 2419801 cttaaaggtt gaacacgccg caacaattgc ttttttaatc gggcttgtag atcttctccc 2419861 ttacttaggt gccggctccg tatttgtgcc ctggattttg tatttatcga ttacgggcca 2419921 gctgccccaa gcaatcggaa ttggtatcct gtacctcgtc gttcttattc agcggcagct 2419981 gacagagccc aagatactaa gtaaatctat cgggatcgat ccgctggcaa cactcatcgc 2420041 cctgtttgcc ggctttaaat tattcgggtt tttaggactg attgcgggac cggctgtact 2420101 cgtcatcatc caagctttca tcacaacagg cgcattaaaa gaaatatggt cctatatcac 2420161 cgttcagcaa aaataaaacg gcagccgttt tttcatggct gccgtttttt atttgatgat 2420221 gatccgctta ttcttcgaca ttcctctcag ccatttgaac agaatcggct tacaccagcc 2420281 gcgggtaaac gggataagaa gacaggcgcc ggccaaatct gataaaaagc ccggaagcat 2420341 cagcaataga ccgccaatga aaatgcacag accgtcagca atcgcttctc ccggcatttt 2420401 gccatattga agatcacgct gaaccttata atacacttcg gttccttgtt tttttgcagc 2420461 tgctgcgccg ataatgccag tcagaatcat gaatagaact gtcggcaaaa taccaatcag 2420521 atttcctaaa aataggaata taccgatttc tattgccgga aacacaataa aaagcaaaaa 2420581 caaaaatctc atatccaagc cccccacacg tgtaacacgt tctgttcaac aaaaggcatg 2420641 ataaagagaa aaggaaggga ttccccttcc attttcacct gtaattaaag aacgctcgca 2420701 cggccttgat agactgcgcc tctggaagcg tcaactgtaa tatcctggcc atctgtcaaa 2420761 atagatgtcg cattttccag acccacgata accgggatgc caaggcttaa tccgactacc 2420821 gcagcatggc tagtcaaacc gccttcttct gtaataagag cagacgcttt ttcaagggat 2420881 gcaatcatat cacggtcagt gcttttggta acaagtaccg caccgtcagt cattttttgc 2420941 tcagcttctt ttgcattttg tgcaacgaca accggaccgt aagctgattt gcgtccaatg 2421001 ccttggcctt tagcgatgat atcgccgaca gtatgaacct tcattaagtt cgtagtgccg 2421061 gactcaccga cagtgccagc tgtaataacg ataagatcgc cgtgttttac aattccgctg 2421121 ttcaatgatt tttggacagc atcctcaagc atctcatctg ttgagctcgc attttggccg 2421181 ctttccgcga atacgccaga tacgagggca agctttctgg aaatagagtc atttacagta 2421241 accgcaacaa tcggagcctg cggacggtat tttgcaatca tacgtgctgt atggccgctt 2421301 tctgtcggcg ttacgatcgc agcagcattc aggttaatcg ccgtatgtgc gacagattgt 2421361 ccaattgcgt ctgtaattgt catgcccact tggtctctgc gttttgagag aatttcttta 2421421 taatttaatg cttcttcaga acgggacgcg atgttatgca ttgtttgaac tgcttcaacc 2421481 gggtaacttc cggcagcagt ttcaccagaa agcatgatcg catctgttcc gtcgaagatc 2421541 gcgtttgcaa cgtcacttgc ttccgcacga gtcggacgcg ggttgcgctg catgctgtca 2421601 agcatttgtg tcgctgtaat aacaggtttg cccagcgcgt tgcatttttt gatcagttct 2421661 ttttgcacaa gcggcacttc ttcagctgga atttccacac ctaagtctcc gcgtgcaacc 2421721 attaagccgt cagacacttc gagaatcgca tcgatgttgt caacgccctc ttggttttcg 2421781 attttaggga tgatttgaat atcctgagcg ttgtgctctt caagaagctc acggatttcg 2421841 agcacatccg tagaacgtcg aatgaaagat ggtgcgatga agtctactcc ttgctcaata 2421901 ccgaaaacga tgtctcgcgc atccttttca gtaatccccg gaagattgac acttacgccc 2421961 ggtacgttaa cacctttttt atttttgagt gttccgttgt ttaatacttt tgttttgatt 2422021 tcgcgtttag cggcatctac atcaagtacc tcaagaccga taaggccgtc atctaacaga 2422081 atcgttgaac cttgttcaac gtcatggact aaaccttcat atgtcactga aattttatct 2422141 gttgttccta caacctcgtc cattgaaata atgagctctt tgcctgtttc aagctcaata 2422201 ccgccgtttt ccattgtatg tgtgcggatt tcaggacctt ttgtatcaag cagaattcca 2422261 acgttcttgc caagtttttt acttgcttcg cggatatttt taattcttgc accgtgctcc 2422321 tcaaaatctc cgtgagaaaa gtttaatcga gccacgttca ttcctgactc cattaatttc 2422381 gtaagcattt caatactttc acttgccgga ccgatggtac aaacaatttt agtttttctc 2422441 atttggttca cttccttctg aaatcttcag ccttcagctg tacattagat agacagttct 2422501 tttgaaagct gatacatgtt ttgctcaact gtgtgttttg tctcaagtat ttctataata 2422561 tcatggtcta caagcttatt gttttgtata cctacacagc gtccgccttt tccttcaagc 2422621 agcagttcaa ctgcatatgc gccgagacgg cttgccaaca cacggtcagc agcactcgga 2422681 gaacctccgc gctggatatg gcccaataca gataccctag tttcaagatt tgtttcttct 2422741 tcaatgcgtt tcccgaattc aacaccgctg cctacacctt cggcaacaat aataatactg 2422801 tgcttcttgc cgcgttcgtg gccgcgtttt aagcgggcaa tgatttcgtg catgtcatag 2422861 tctgcctcag ggattaagat cgattctgcg ccccctgcaa gaccggccca caatgcgata 2422921 tcgccggcat gacggcccat tacttcgatt acatatgtac gttcatgaga agtcgctgta 2422981 tcgcgaatct tatcaattgc gtcaattact gtatttaaag ctgtatcgaa accgattgta 2423041 aaatcagtgc ccggaatgtc attatcaatt gtacccggta cacctacaca tggaaacccg 2423101 tgttccgtta attttttcgc acccatatag gaaccgtctc caccgataac aacaaggcct 2423161 tcaataccaa gcttcttcaa gtttgctatc cctttttcac ggccttcaac tgttttgaat 2423221 tcaggacatc tcgccgtata aagcttagtc cctccacgat gtataatatc gcctactgat 2423281 ccgagttcaa gcttttcaat ctttccgctg atcaatcccg cgtatccgtt gtaaataccg 2423341 taaacttcaa cgtcatgata gatcgctttt ctgactactg cgcgaactgc tgcgttcatt 2423401 cccggggaat ccccgccgct cgttaatacc cctattcgtt tcattctcca ttcacctcag 2423461 caacatatat gattaaacat aacatgatca ttgccctaaa aacaatgaaa agggatctcc 2423521 atcctcccta tgaaacctta cctattatac aattaaataa attgttttta aataaaattt 2423581 aaggaatgtc acaaaaaata aacgtgagcc aaaggcttca cgtttattta gtttaccccg 2423641 atatattgat cttcaaccga gactttgcca attgctttat atttttcata acgctgctga 2423701 actaattctt cttcgctcag cttcagtaaa gtttttaacg attgtttaag ggtttcgtcc 2423761 atatagcttg cctgcagctt cacatcatgg tgcgctccgc cttttacttc tttaatcata 2423821 tgatctataa tacctaattc ttttaaatcc ggcgcagtga ttttcattgt ttctgctgct 2423881 tttttagcaa gactggagtc cttccataaa agtgccgcgg caccttccgg agaaataaca 2423941 gaataagtag agttttccag catatgcaag tgattgccta cacccagacc aagggctccg 2424001 ccgcttccgc cttcaccaat gacgatgcag ataacaggca ctcgaaggcc ggccatctca 2424061 aacaggtttt tggcaatagc ttcactttgt cctctttctt cagctgctcg tccagggtat 2424121 gcccccttcg tatcaataaa acagataatt ggtctgttaa atttgtcagc ctgtttcatc 2424181 agacgaagcg cttttctgta gccttctgga tgcggcatcc caaaattgcg gactaggttt 2424241 tccttcgtgt ctttgccgcg ctgatgcccg attaccgtta cagggaggcc gtggaacttc 2424301 gcaatcccgc cgacaatggc ttcatcgtcc ccgtacgctc tgtctccgtg acattcaaaa 2424361 aagtcggtaa acaggtgttc gatataatca agagttgtcg gacggtccgc cagacgcgcg 2424421 atttgaaccc ggtcccacgg cttcaaattt ttgtaaatat catcctgaag cttagcgaga 2424481 cggtcttcga gccgttcgat ttccgcactt agatccatat cggaatcttg ggtgaatttt 2424541 tttagttcgg cgattttggt ttgcagttca atcaccggtt tttcaaattc taatcttgga 2424601 gccactcaat gtcacctcct gtttgatgca tatccagcag attttctaac gtttttttca 2424661 tatcgtcgcg atgaataacc gcatcaagct gtccatgttt taataaaaac tcagccgttt 2424721 ggaagtcctc aggcagtttt tctcctattg tctgttcaat aatccgtctt ccggcaaaac 2424781 cgatcagcgc gccaggctca gcgaaattgt aatcgccaag ggatgcaaag cttgctgata 2424841 cgcccccggt agtcggatgc gtcattactg aaataataag accctgttct tcactgaaca 2424901 gttttaacgc agagcttgtc tttgccatct gcatcaaact taatacgcct tcctgcattc 2424961 tagcaccgcc tgaagccgta aaaataataa acggaacttt atcagctttt gctttttcaa 2425021 tcgcaagcgt gattttttca ccgacgactg aacccatgct gcccattctg aatgaagagt 2425081 ccatgacggc gacaacagcc gggtgtccgc cgatggtgcc cttgcctgtc acaacagcct 2425141 cgtttaagga tgttttctcg cgatcttttt caagcttttc cagatatccc gggaaaccaa 2425201 gcggattttc cgagagcatt ccctgattaa attcctcaaa ggattgttca tccatcaagc 2425261 tttcgatacg ctgttttgcg ttcattggga aatgataatc gcagttcatg catacccgca 2425321 tatttttatc caactcttta gtgagcatga tttttttaca cttaggacat tttgtcataa 2425381 tgccttccgg aacatcgtgc ttcgcttgat cagacggtac ggaagcatac tttttctttt 2425441 tcgtgaatat atcctttaac aaatgattac ctcccttttg tgaagggttc tcttcaccgc 2425501 atgtcatcaa acagatagac ttgctaataa ctttaccgaa actattgtac tttttttgtc 2425561 aaacgctgtc atcctcaatt cgacaacttt ttattcgatg acgtgctcgg aaaggcttgt 2425621 atgaaatcag ataaggtgtt gaaacgacaa ggttgacagc gcattcaaaa ataatgttaa 2425681 acccggctga aattttttta aggctaaccc cctaaaaaaa tttcagccgt cagtttaact 2425741 tgagaacagc gcgccggtct ccgccaacgc gctgccattt ttggaatgaa ttaaaattat 2425801 tcaccaataa tcgtaagttt tcttgttttt tctgcgactt cctcagggtc aacagtgatt 2425861 cttgcaacac ctgtttccat cgcagctttt gccacagcct tcgcaacagc aggcgcaaca 2425921 cgtttatcaa acggtgcagg gatgacatag tctgcgctaa gctcatcttc tgaaaccagt 2425981 gaagcaatgg cttcaaccgc tgcgattttc atttcctcgt taatatgagt ggcacgcaca 2426041 tcaagcgctc cgcggaaaat accagggaat gcaagaacat tgtttacttg gttcgggaag 2426101 tcagaacggc cagttccgac aacgcttgct ccggcttcac gcgcatcttc cggcatgatt 2426161 tccggatttg gatttgccat tgcaaagata atcggatctt ttgccatgct ttgaaccatt 2426221 tcttttgtta acgcgcctgc tacagagaca ccgataaata cgtcagcatc aacgataaca 2426281 tctttcagag aaccgtcttt gcgatcttgg ttcgtgaact tcgccacttc atttttgaca 2426341 tcgttcatgc cgttcgggcg cccttcataa atggcccctt tggaatcgca catcacaatg 2426401 tcgcgaacgc cataatgatg aagaagcttg ataatcgcaa tgccagccgc acccgcgccg 2426461 tttgcgacaa ctttaatgga tgacatggat tttccagaca gtttcagcgc gttcacaaga 2426521 cctgctacgg ttacaatggc agtaccgtgc tgatcatcat ggaaaaccgg gatgtttgtt 2426581 tcttttttga ggcgctcttc aatgataaag cagtttggcg ctgcaatatc ttcaaggttg 2426641 acgccgccaa atgtcggttc cagcaatttt acagtttcaa cgattttatc aacatcgttt 2426701 gtgtttaaag caatcgggaa cgcatctacg cccgcaaagc ttttgaaaag aactgctttc 2426761 ccttccataa caggaagcgc cgcttcaggg ccgatgtttc caaggccaag cacagctgta 2426821 ccgtcagtta caactgctac catgttcccc ttcattgtat aatcatatac tttgttaatg 2426881 tcttcatgaa tatccttaca cggttctgca acacccggag aatacgcgag gcttaaatct 2426941 ttcgcatttc tgacctctac ttttgattta gactccagtt tcccctggtt gactttatgc 2427001 aggtgtaatg cttcttctct taatgacatt ctcctaaaca ctccttatgg atattttttg 2427061 attcgtatac tgctgcgttg attgctgcat tctgcggagt aaatctatct gaatatttaa 2427121 acaggatcac ataattgctc caattgtata acaaaaagcg aatcgttacc actgttttaa 2427181 aacgacgttt ttttgaccca acagctcttt taagcgatat aacacctggt gatctgcatt 2427241 gatatggaac gactcaggta gcttaatcgt ctgtttttgc ctttcataat agagataaac 2427301 gcctgtttcc cctttatgct ccagcaaaat gcgcttaatc tttgccagga tctcctggct 2427361 gtgctgactg ctttctattt ttatataaac cgatggcgct ttttctgcat ccatatcttc 2427421 taataattct gcccgggaca tgatgaattg gatcttatct tgtctaactt cacatttccc 2427481 cgcagtgaac aaaagagcgc cttctcttaa aacgggagaa agctgtctga attgttcagg 2427541 gaagactacg gcttccatct cgccggtttc atcactgagc gttaaaaacg ccatgttttg 2427601 acctgttttc gtccgaatcg ttttgatctt cgacagcaga acgcctagtg aaagctgcct 2427661 tttgactgcc cgctgagcct gcagaatgga gactgctcct tgcgcagtga gctgttttcg 2427721 gaaggcggag aggggatgat ttgaaaaata aatgccaagc gtttcctttt caaacgcaag 2427781 taaatccacc agaggaagct cctccgtctc cacatacttc ggcttaattg aaaacgattc 2427841 atctaaaaac aatcccattt ggtcatcgtc cgcggcgaat agctcagcat gttccaaagc 2427901 aacatcaatg gatgcgagca gcgtggcccg gttttggccg aattcgtcca tcgcaccaga 2427961 aaagataagt gcttcaagca ttttgcgatt tacgcttttt gacggcacgc gaaagcagaa 2428021 atcgaaaaga tcttcaaatg gtttctcttt tcttgcttta tatatatctt tgactgctga 2428081 gacgcctaca ctttttatcg cgcggaggct gtatctgaca gatccgtttt caactgtaaa 2428141 cggaaaactg cttttattca ctgacggagg aaggatacga atcccgctcc cctttgcttc 2428201 gtaaagatat tgagagattt tatcctcatt gccaatgacg cttgtcagca atccgcacat 2428261 aaaatataac ggataatgag ctttcaaata cgcaagctgg cacccgatca tgctgtatgc 2428321 caccgcatgg cttctgttaa agccatagtt tgcgaatttg acgattaaat cgtagacctc 2428381 atttgcagtg tctacagaat actccttttt taagcaccct tcaacaaaat ggcttcgctc 2428441 tctgtccagg atttcttttt tctttttgct gaccgccctt ctcaataggt ccgcttcgcc 2428501 taaagaaaac cccgccatac gggaagcaat catcataatt tgttcctgat acacaatgac 2428561 gccatatgta tcttccaaaa tgctccttaa atcttcatga ggatagtgaa caggcgcccg 2428621 accgtgttta cggtcgataa ataacggaat attttccatc ggacccggcc ggtacagtgc 2428681 attgaccgcc acaatatctt ctaggcccga aggtttcagc cgtttcaaga cgcttctcat 2428741 ccctgcagat tcaagctgga aaatgcctgt cgtatcccct tttgacagca aggagaacgt 2428801 tttgtcatcg ctgtaggaaa tacttgaaag gtctatttta atattttctt ctttttcaat 2428861 cattgaagtg atggattcaa taagtgtcag attcctcaaa cctaagaaat ccatttttaa 2428921 aaggcccaag tcttcaagat ggtccatcgc gtattgcgtt aaatagatcc cttcatgccc 2428981 ttcttgaagc ggaacaacat ctgttaacgg ttcttcactc aggacaacgc ccgctgcgtg 2429041 ggttgatgca tgccttggca gcccttctat tttccgggca attgaataga cttgctgaag 2429101 caggcttgac tcccgaagcc gcttatccag ctgcggtgac tgctgtctcg cttcatccag 2429161 cgtcattccc ggtcttgaag gaatgagttt tgcaagctga tctgcctcct tcgggctgac 2429221 gccgaatact ctgccgacgt cccggagcgc cgcctttgcc gcaagtgttc caaaggtgat 2429281 aatctgtgcg acgtgcattg caccgtattt ctgctgaaca tattgaatga cttcatccct 2429341 tctagtatcg ggaaagtcaa tatcaatatc cggcatgctg acgcgttcgg gatttaaaaa 2429401 tctttcaaac agaaggtgat gcttaatcgg gtcaacatct gtgatataca gcacatatgc 2429461 cacaagagaa cccgccgcag aaccccttcc cggtcctgta acaatccctt tttcatgggc 2429521 gtgcttcata aaatcccaca cgatcagaaa gtaatcgctg aacttcatcc gcttgatgac 2429581 atcaagctca tattgaagac ggcgaaggta tcgttcatca ggcttgccga aacggctgcg 2429641 gagtccctcc atacagatat ccgttaaata atcatcagcg gacgttccgt ctggggtcgg 2429701 aaaagacggt agacgggtct gcccgagact gacgtcaacc cggcattgtt ccgcgatctc 2429761 tacagaagct tgcagtgcct cgggatgctc tcgataaatg ttttgcattt cttcgagtgg 2429821 tttcaaatcg agatcaggca aatcttcagc gggtgcatcc gtcagttttt cccccgcttt 2429881 aatcgctttc aaacaacggt aggcagcctt atcttccttc cttatgtaat gcacatcgcc 2429941 tgtggccgta acagggatac ccgtttcttc tgacagcttt agaatctgct cagacaagac 2430001 ttgattccct ttaaaaggct gataggagaa ataaaaagct ccctttccga atatagactg 2430061 aaattccagc gaggcttgag cagcctgttc gaacagccct ccttcaagaa gcgtttcaat 2430121 atatcctttt tcgccgggcg ttattgcgat aatcccttct cgataactgt gaagccattt 2430181 cggcttcagt ccgccttttg atttagattg cagaacgctg ctgattttca gcaggttttg 2430241 atagcctgta ttcgattttg ccagcaggac gagcgggtat gcttcaagct cgctgtcatc 2430301 tgtaaaaaca gaagccgtca aaccgattat tgggttgatc cctctcgcct tgcaagcttt 2430361 ataaaattga atagctccgt acatgacatg atcatctgtc agcgccaaag acgcatatcc 2430421 gagcctgtca gcttcactga cgagttcttc cacagccgcg gcgctgttta gcaggctata 2430481 cccgctatgc acttgcaggt gaacaaaaga catgctatca cctctttctc attacgatcc 2430541 atttcttcct tcattataag gccggtttcc aaaagaaaca aatgttcttt tttgactcat 2430601 catcatactt gtcctgaaag ctcaatatga tataaaaggt gaggtgataa agatggatca 2430661 ggaagcagga tttatggtga attttatcaa tagctacttc attgcgttag gggtgctgat 2430721 cgggggcgca ctcatcggag ggctcggagc atacttggca ggcgaacccc cgcttacagc 2430781 cattacaaag cttgccaacc ggttaaaaat atgggcgctt gtcgcagcta tcggaggcac 2430841 ctttgatgcg gtatacagct ttgaacgcgg catactcgaa ggcaatacga gagatatctt 2430901 taaacagctt cttttaatta tttcggccat ggggggcgcg caaagcggct ggcttattat 2430961 atcatggctg acccaggagc atctttcttc atgagggtcc cccagcatta caaaaaaccg 2431021 ggatggcagc gttttttcgc gggaatgatg tgcggagccg taatcagctg gttctttttc 2431081 ctgtttactt acggaacatt ccaagaggag caggtcagcc tcatcgaaaa gcaaaaagag 2431141 catgtaaaag acttgaacaa tcaaatttcg atctatcagg aagacctcca taaactgaat 2431201 gaagataata aaagaaaact gctgattcaa agcgtcagcg tcaaattgct gaatggggat 2431261 aaatataaaa tatcacagcc ggataaaacg aaattcgagg agcatgtaaa ggatgatatt 2431321 tcagaggtga ttacaaaaga catagagagc gtctatcaaa caaaggatct cttgaagcgg 2431381 acaattgaaa ataaagtcta tatgatcaat gaaaaaaaat acgaggcaac cgtcagagaa 2431441 ttgattattt atacgaggct gacagtggaa cttgaaattt ctttcgccac ataattatgg 2431501 atttttttta aattctccaa acttctgtcg ctttttccca ttctttttta taaactatat 2431561 gtgaggctta atggcgaaag gaaggaggaa gggaaatgga ggtttacagt gaccgtcagt 2431621 tagcaaaaga tcaagcagcc cgtctcagac aaggtttttc tgcatatgcc gaaacaaact 2431681 cactcgcttc cctcatcaaa aaagaacttc aatcacacaa tctccaagtc tacgaggacc 2431741 ttactgattt cggctgctgg ttcatccccg tcacagatga acactaagag agagggtctc 2431801 ccctctactc gtgttcttta cataatgttt ccagatcagc taaaatacga tcagcttcat 2431861 cccagctgta aatagaggcg cctgaagcta acggatgccc tccgccgtta tatttccggg 2431921 caagtccgtt aatgacaggc cccttcgaac ggaatctgac tctgatttga tcgtcttctt 2431981 ctacgaaaaa cacccaggcg cgaatacctg agatattgcc aagcgtcccg acaagctgcg 2432041 acgcttcaga agccgttgtg ccgaattttt caagcgtatc ctttttgatg aaaacagaag 2432101 ccgccccgtt ttcggacaaa gacacatttt gaaagataaa gccgttaagc ttcaccacat 2432161 tcagttttgt ttcatacaat tgattaaata actctgagga agagaatgga tactgaatga 2432221 gctcgcctgc atattttagt gttttttccg tggtattcgg aaataaaaag cgtccggtat 2432281 ctccaacaat gccggcgtag atcagctctg ccgctttcgt attcagcttc cagccgtgct 2432341 cttttccttc taaatacagc tcgtaaatca tttcacttac tgagctggcg cttgtatcga 2432401 cccagagaag gtcaccgtat ggatcttcgt tcggatggtg gtcgattttc attagtttgg 2432461 cgcctgaagg ataacgctga tcgtcgattc tttcctgatt tgccgtatcg cagacaatga 2432521 caagtgcgcc ttcatatgtt tcattgtcca cctcatcaag ggaatataag aaagagaggg 2432581 acggttcagg cgtgccgacc gcaaaaatat ttttttcagg atatgtttca cgcaggattt 2432641 ccgtaagccc acactgtgat ccgtaggcat ccggatcagg acgcacatgt ctatgtaaga 2432701 taatcgtgtc atataatgat atggttctga tcaattctgt tttcatttga tactccttta 2432761 ttgtttttat tcattaaatc acattctctg ccgacggaaa agaaaaataa cgtcaaaacc 2432821 aagcccgttt ttgtataaaa tggggttgta aacttttacg atggaggatt tcatttatgc 2432881 tggttcttgt ttttttgatt gggctttcag cctgctttta tgtgtactat aaagtaaaag 2432941 gcgtacgggc aaagccatct ttggcaaaag aaatatgttc agcaaaatca agcatggcct 2433001 tagggtcact agtcctgttc tacgggctta accaaatgat attattccat tcagtattaa 2433061 cgttagtaat cggcggtatc tttatcgtca taggagcagg aagcgcttgg gcaggttata 2433121 aagccttcag gcattacaat ccccttcacg ccaaagaagc tgaaagagat cacgcgtaag 2433181 gggcgcctga acgtccctta gcttctttcc atcagctgaa ccatcagcat cgctttagac 2433241 acgatatgac cttggctgtg cacttccact tccattttcc caaactttct gccggcctcc 2433301 aagatgcgag gtttgacttc gatgactgat tccatctgca caggcttcaa aaagaagatg 2433361 gtgatgctct ctatgacgag ttcgccgcgt tttttcgagc gcaaaaatcg gtttgccgct 2433421 tgcgtcaaaa tggtcgtaaa tacgccataa gaaatggttc caagctgatt tgtcatttgc 2433481 ggcgtgactt catactcgta aaccgtttga tcttctttat catcaccctc atctttaaac 2433541 ccccttgaaa cgatatcatc aagcttctcc ccgacctgcg gctgcttttg aatcatttga 2433601 agagctttca atacgtcttg gcggctgatc atgccgatga gtttttggtg gccgtcagtg 2433661 acgggaagca cttcgatccc ttcccatacc atcatttgcg cagctgaagc gacagatgtt 2433721 ttcccaataa ccgtgacggg atttttggtc atgacttttt ctatagatgc atttcggtca 2433781 tggccagcaa tatcttttga tgtcagaatg ccatggattt tcatttgatc gtcgacaacc 2433841 gggaagcggc cgtgccccgt ttcaaaattt ttctcatacc atttttcaag tttatcctta 2433901 ggcgaaagat ataccgtgcg gtcagcaggt gttaggatgt cctccaccaa aacaatttct 2433961 tttttgatca gctggtcata tattgcccgg ttaatcatcg cggcaactgt aaaggtgtca 2434021 tagctcgtgg ataaaatcgg cagttcaagc tcatctgcca gctgcacaat gctgtcatcc 2434081 gtgttaaagc ccccggtcac caatacggcc gcgcccgctt caagcgcctg cctgtgtgca 2434141 ttgattctgt ttccgacaat caaaagattc cccgctgcgg tgtaacgcat catcgcgtca 2434201 agctccatcg cgccgatgac gaatttattc aatgtcttat ggagccctgc cctgcctccg 2434261 agcacttgtc cgtctataac atttacaacc tctgcatagg taagcttttc aatgttctct 2434321 tttttctttt gttcaattct gattgtgccc acacgttcaa tcgtgctgac aaacccttta 2434381 ttctctgctt ccttgatcgc tctgtacgcg gttccttcgc ttactttcat ttcctttgca 2434441 attcttcgga cagaaatttt ttcaccgaca ggcagtgaat cgatatacgt taaaatttgt 2434501 tcatgcttcg ttgccaagcc tttcacctct aaggacagtc ttcttgtttt tattataagg 2434561 tttcaaagga tttatacgca atgaggctgg aaaataaaaa agaagcccga ccggcttctt 2434621 acagcgttga tttcgttcca gtcaaacgca aggaccacgt gattcctttt acatcgtaaa 2434681 gcggaaaaac ctttattttt cttttaaatg gacatcaacc gctgtcttaa caatatttcg 2434741 attccctatt ttagataaaa caaataaaac tgcggatagc catatcgccc ctatggccgt 2434801 atagatcaat ggatgaacag ctgtgtttgc gatccattca tttattaatg ttctggcatt 2434861 taccagaata ataaatcctc ctacaagcac acccatcaat tgcggatgaa acttctgcac 2434921 cagccatgct gcgatagggg cagcgataat tccgccggcc attagtgaaa acacccataa 2434981 ccaattgacg tcctcccatc ctaatgaaat aagaaaaccg gcggttgcag atacggcgat 2435041 ggcaaattca cttgtgtcta cagtcccgac aactttcctc gggctcaagc ctttgcggga 2435101 taataaaatc ggagtggtca ccggtcccca gccgcctccg cctgtggcat ctgcaaaacc 2435161 agcgatcact cccaatggga tggattgttt tcggtttaac ggcacatgct tcttctcaag 2435221 agccggctta tattgaaata aaaacctgat caatacatat ccgcccagaa ggagcaaaaa 2435281 caaagaaata tagggtttcg ccacatctcc aggtaattgg ctgaggaatg ccgcgcctaa 2435341 aaaagcgcct atagagccgg gaatgacaag ctgataaacg gtttgtttgt caacattgcc 2435401 aaatttaata tgcgacactc ccgatgcggc agtcgttacg acttccgcta aatggacaga 2435461 agccgaagcc acagcaggtg tgatgccaaa cgccaataac aaagaagttg aggtaacccc 2435521 ataagccata cctaacgaac cgtctattaa ctgcgacaat aaaccaataa atgcaaaaac 2435581 gattaatttc ttcatcagaa caccccatct atatcaatca gatatttttg actcttcatt 2435641 cgaatctaac aatctcttgg cgctttcata taaaaaataa gaggctttga taattgcagt 2435701 ttcatctatt gtaaatgcag ggtggtgcca atcatgatca ccgtctgttc caaaaaacgc 2435761 aaaggatccc ggaatatgct caagataata agcaaaatct tcccccgcgg ttgatggggc 2435821 gggatcaatg acttgaagtt tcgctttatg tgcagcgtct cgcaccagcc ccgtaattgc 2435881 ctcatcatta caaagcggcg gcggtccgga atgccacttc acatttgcct ttaacgagaa 2435941 agcggcagaa atctgctctg tgactgcaaa aaaacgctgt ttcacttgat tacgaacctc 2436001 tgaatcaaat gtacgaacag tgccctcaat gaccactgta tccggaatga cattccaagt 2436061 gctgccgccg ttgattttcc ctacggttaa aatcgcgctt tgcagcgggt ttacatttct 2436121 gcttacaatc gtttgcaggg cgacaataag ctgagaggcg ccgataattg gatcaaaacc 2436181 attatgcggc aatgctgcat gagcaccttt cccttctatc tctactttaa atcggtcaac 2436241 agcagccata agcgggcctg tttttaaccc tacagtccca accgcgatat ccggtttatt 2436301 gtgaaggcca ataaccgcat caatgccatc cagttggccg tcctctatca cttttgtagc 2436361 gcctgcaccc gcttcctctg ctggctgaaa taataaacga atctttcctt tcagactgtc 2436421 ttgattttcc ttcaataaaa aggccgcacc aagaagcgct gccgtatgaa aatcatgacc 2436481 gcacgcatgc atgatccctt tatgtttaga cgcataaggc aatcctgttt tttcttcaat 2436541 tggcaaggcg tcaatatcag ccctcaaagc aatcgccgga ccttctgact cccctgctat 2436601 gtctgcgaac acacccgttt ttagagcagt agggcgaatc tgtatcccct tttctttaag 2436661 gcattttttt ataaaagcag ttgtttcaaa ttcttctttt gacagttcag gatattggtg 2436721 caggtgccgg cgaatgccga tgagctgctt ttctagcgtt gagagattta cgggattaga 2436781 ctcctctttc aacgtcagga tgtcatttcc tgtagtctga tatggatagg agccttctat 2436841 atttctccaa taatccaaag acatatgttc cgctcctttc cctatcccaa tatattttct 2436901 tcagactctt caacataaga tgaaataaat cggttcaatt tatcagcaag accgcccgcc 2436961 ccaaatctta tatacttgct ggaaactttc ggattatctt ctttcaaaaa gcttaaaaaa 2437021 gataaaatat aaatgcgcct gtaagctact tgtgtaattc cgtactcaaa aaaccagtta 2437081 tcaatgacat tgtatacgcc tcggttgacg ccatataggt tattacattt cttgtaaaag 2437141 cagagatccg gaagatttaa ctcctgatgg gaaagaaggc tttctttttt gtttggtgcc 2437201 ataatcccaa tcagctcaaa gcgttttgca acgcacgaaa tatccttttt aatttgcttt 2437261 gttaaagact ccaaagaatc aaaccttctt tcttctctaa ttttaaagag aatgctgcat 2437321 tcgatttttt ctccataaat gtctctatga aagtcaaaca aaaaaatctc caatgtcttt 2437381 tcaaggttag agcccaccgt cggtttcaca ccgatattca taacccctaa atgaaattga 2437441 tgattgactg tcgccagaac cccataaact ccattacgca gcccatgtat ttttgcatct 2437501 acatttgccg tggggaatcc aagctttctg cctaattgtt ttcctttcac aaccgtaccg 2437561 gcaatgatcg tcaaaaaagt cagcctcctc tctcagcttc cgcattcgat cagacgaaac 2437621 ctaatgatgt gatgaatgta aaacggattg atgctgcgga atgccaagac cgagattttc 2437681 ccgcaatgtc ccgccgcgat aatcttgacg ataaagccct ctttcttgaa gaatcggaat 2437741 caccttttct acaaaagcat caagtgttcc cggtatatcc gacccaacga taaacccatc 2437801 cgccgcctca gcgttgaacc aagtttcaat taaggatgcg acacgctctg gtgttccgat 2437861 gaatagagtc cgtggaaaag ccatttcctg tgctacctcc cgcaatgtca gatttctggc 2437921 ttttgcttct ctcttaatcc ggtctgttgt gctttgaaac gcattctttc ccacatcgcc 2437981 aatatcggga aatggctcat ccaacgggta aacactcaga tcataatcat caaaaaaacg 2438041 ggccaaataa gtaacagcat tttcaatcgg tatcaattct gcaaattcac gatacttctt 2438101 ttccgcctct tcttccgtat ctgccacaat cgggctgatc cctggaaaaa tccgcacact 2438161 tgaaggatca cgcccttcat cagcagctcg gcttttcaca tccgcataaa acgcttttgt 2438221 ctcttctaat gaattggaat gggtaaaaat cgcatccgca tttttagcag caaactgccg 2438281 gcctgtttct gatgaacccg cttgaaacac tacaggctct ccctgcttag agcgcccgat 2438341 attcaagggc ccctctactt gaaaatactt tcctttatga ttcaggcgat gaagcttcgc 2438401 ctgatcgaaa aactgccctg ttttcttatt gtgtataaat gcgtcatgct cccaggaatt 2438461 ccacagcccg cgcacaacat ccaaatgctc ttgtgcgatc tcgtaacgtt cagtgtgttc 2438521 tggcaaatta gacttactat ggttgcgcgc cgctccttcc tgcggcgaag taaccagatt 2438581 ccagccggcc ctgcccccgc tgatatggtc cagcgacatc aattgtctgg agatagtgaa 2438641 tggctcagta aaagatgtag agaacgtccc tactaaacca atatttttgg taaccgatgc 2438701 cagcgcagat aaaatggtga tcggttcaaa acggtttaaa aaatgaggaa tcgatttttc 2438761 agaaataaat aagccgtctg caatgaaaat aaaactaaac aaaccttttt cagctgtttg 2438821 cgcctttttc atgtaaaatt caatattcgt gctggccgag ggatcaacat cgggatgacg 2438881 ccagccgtca gttgttcccc cgacaccgtg aatcatggct ccaaactgaa taaaatctgc 2438941 acgtgtcatc tttttgcctc ctttatctgt gcatgattag caagtgcaag atcaaggtgt 2439001 tcaatgccga tttcagttat cccttgatac tgattgccgc gcccgatttc gaccacaggc 2439061 acatggcgca ccccatattt cacctgtaaa atatcccgaa gcttttcttt ctctgaaaca 2439121 tcgatatttt ggaacgggaa ccctttttca ttcaaataat tcttgacttc ctcacaatac 2439181 gaacagcctt ttttactcca aaccacaatg ttcacaacat cactcattct tctgtccctc 2439241 cttaacgttt tgcagctaaa actgcatcgc tcagcagctg ataagacagc tgtttttcta 2439301 cagcattttt gatcggtgta aaaataacaa aatcattgat tttgtatgtg cctgataaac 2439361 gtgttaattc ttctgccact tcttcctttg ttccggcaat aatcccggtt ttttgcacga 2439421 tgatgtcata gggctctgtg acgttttcca gataggcctc agcctgttcg cgggaaccga 2439481 cgttgacctt acgcccgtct ttcaaaacca cttttatcga ttcacgcgac acaatatgtt 2439541 tttccgcttc ttcttttgta tgtgccgcaa aaacagcggg ggcaagatga aattcagcct 2439601 cagatcctgg cgggagatgc gcgtcaaatg ctcggcgggc ttccttcagc acttcctctt 2439661 caccgttaat aaagtaagca aagacaaaag agattcccag ttttgcagca gaaatggcac 2439721 tctctgtgct tcctcccaat agaaaaatac ccggcttccg atcaacctgc ggcctaggac 2439781 gcaatgcggc atagcggtgg gtatcaggaa aatcatcccg aacgaaatga gtaagctcct 2439841 ccagtttttc atcaaactga cgcaccggtt ttttatattc ggcctgcagc gcgtctgtgg 2439901 acagctgaaa cccgccgggc gctttgccca ctccaagatc tatacggccg ggagctaacg 2439961 ctgatagaag atggaattgc tccgctactt tataagagct gtaatgctgc agcatcactc 2440021 cgcctgatgc taaacgaatt tttcttgtgc ttgcagcaag atagcctaaa agaacctcgg 2440081 gtgcagaccc tgcaatctca tcattgttgt gatgttcggc cacccaaaat cggtgatatc 2440141 cacattcttc agccatttgt gccaatttca ctgtatgctg taatgtatca gctgctgtct 2440201 ccccttcacc aatcaagctt tggtctaaaa tacttaagcg gatcatatca ccggctcctt 2440261 tatgtgttct tttggttcaa ataaatattc cggcgaaaca cggcggagaa actgcctcgt 2440321 tctgtctttt ttggtatggc ggaagacttc ctccggggtt ccttgttcaa caatgactcc 2440381 ttcatccata aaaacaactt gatcagagac ccttcttgca aactccattt catgtgtaac 2440441 aacaatcatg gtggctccgg ttttcacgat ttccagcatt acctcaagca cttcaccgac 2440501 cagctccggg tcaagcgctg ccgtcggctc atcgaacagc agcacatcag gatgaatggc 2440561 aagcgccctt gctatcccta ccctctgctt ttgtcctccc gataactgac tcggataagc 2440621 gttcaattta tcttgaagcc cgacctttct cagttcattt tccgctacgg catacgcgtc 2440681 ttgttttctc attttccggg caatcgtcaa gccctccatg acattttcaa tcaccgtttt 2440741 gtgagcaaac aggtggtatt gctgaaatac cattgccgtc tgttttctga gccagtgaac 2440801 ctcttttttg gacggaaagc ggcaattaat cactttgtca tgtatagaaa tgatcccttc 2440861 gtctggacgt tctaataaat tcaggcaccg taaaaaggtg gttttccctg atccgctcgg 2440921 cccgataatc gtcacaactt ctcccttgcg taccgtgaga tttatccctt ttaatacatg 2440981 gtggatgcca aactgtttat ggatattttt aatctcaatc ataaagtgcc tccttgaaat 2441041 ctggctgcct ttctctctaa tactccattt gcggattcta ggattagagt cagcacccaa 2441101 tagataatcg ctgctccgat aaacgcttct aaaaatgcat aattatcaga agcaacgata 2441161 gtcgccgtcc ctgtaatctc tgggacagcc actatagccg cgatagaggt ggtatgcaaa 2441221 aagccgatac ccaaatttgt gaagtttggg atggaaacct tcagcgcctg cggcaatatt 2441281 acacgccgaa aggtttggct gtatgtcaag ccgattgaat aagccgcttc gacctgtccg 2441341 gtatccatcg ccagaatgcc cgaccggatg atttctgtga gataagctcc ggcagttaaa 2441401 gacaaggcca tgatgacaaa catggagacc ggtatctcat tagcggacca gccgagatga 2441461 aaaaaactgc tgacttgatc tgcaacaggc ggtatcccta aataaatcaa cataatgtga 2441521 agaattgcag gtgtacttcg aaagaaagac acataaaacc ttgagcaagc caccaagccc 2441581 ttaattctaa aaattctaac aattatattt ccaagagcca cgagaaatcc aaacacaatc 2441641 ggcaaaacag ccatcatcaa tgtcagagga atggtcttta ccatttcttt catggcggaa 2441701 acgataaatg gaaagtcaaa ttgcaatctt ctcccccctc atccgaagaa atatatcaat 2441761 gtatgttcat gtcaaaaaca gtaacaatcc ttgtttgatt cttcttgatt cgtttttctg 2441821 ccactcgaaa gaaccattcg aataaaaccg ctacagcata ataaacaatc gatagcgcaa 2441881 tgtaaacttc aagagaatgg ttgcttgagg taatcagtgt ttggcccctt ccggacatat 2441941 ccataacacc tattgaaaag gctagagacg tatcttttaa agaactgatc accatgtttc 2442001 ccatattcgg aaacgcctgg acaagtgcct ggggcagaac gattcgcctg aaggcctgac 2442061 taccgcttaa gccaatactg tacgccgctt ccgtttggcc tttatctaca ctgcccaccc 2442121 ccgctcgaat gatttctgcg gctgccgctg cattgcttaa cgcgtaggtt gcgacagcag 2442181 cataaaacgg gtccattttt gatgtatcaa tcccgataag ccccgtaagc gccgggatcc 2442241 cgtaaaacac gatgaaaagc tgcaccatga taggcgttcc cctgaaaaac gagatataca 2442301 cttttgccaa ttgatttaca attggaatat tatagatgcg gggcagtgcc agaaagagtc 2442361 ctaatacaaa accgaaaagc aaggacagtg ttaaaatgta taatgtaacc ggtaaataag 2442421 cggttaacgt cggcacaaaa tctccaatca tgttcatatc aaacgctttt tccatcactg 2442481 ctccctctct ttttacctaa tactgctctt tggaatagtc gtcaccaagc catttcaaac 2442541 tgagcctttt caacgttccg tcatcaatga tttcctgtaa ggctttatca atatcgtcac 2442601 ttaacgtttg ttcatttttg ttaaacataa aatacacttt ggcatttgaa agcacattac 2442661 cgacggtttt ttctttaata gtgctcgtct tgttttgaaa gtctactgca aaaggcgttg 2442721 agatcgttgc gtccgcacgc cccgatttca gctgattcgc agtctcattt gcgccttggc 2442781 cctcataggc aatctcaaac ggccgtccat tatcctcatt ccattttttc agtacaagcg 2442841 ctccgttgga ggttgcactc gtaatcaccc gttttccttt taagtcttca attccacgga 2442901 tcgtatcgtt attttgaagc acagtaattt ttaaaggaaa atggttgtaa gcaaccttgt 2442961 taaacagaaa ttttttctca cgctctttgc ttttctccat ttgatgtgcc acgatatcga 2443021 ctttatgctg tccgaggctg acaagcaggt tggaaaattc catcgtttta aatgtgaatt 2443081 tataatgtgg caggcgctta tcaagctctt tgatcagttc gacatcataa ccggttaaat 2443141 cgcctttttc atcgataaag caaatattcg gaaattgggt tccagttccg accgtgatcg 2443201 tctgtacctt cttttgcccg gctcccgtcg tttgactgcc tgcaccgcaa gctgacagaa 2443261 ctgttataag cgaaaataat attgccatga atgctgtttt cgttttcatc tcatcgcccc 2443321 atttattttt caaaacttga ttttgaataa tctgccccga gccattttcg gcttagtttt 2443381 tttagcgttc cgtttttctc cagcttttta atcgcttgat ccgtgtcatc cgccaaggtt 2443441 tggctgcctt tattaaacat aaagtacacc tcggtatcta ataacacgtc accgactgtc 2443501 ttttggcgga aggcgtgcgt tttattctga aaatcgacgg caaacggtgt agctatcgtt 2443561 gcatctgcgc gcccggtttc aatttgattg gcggtatcat tgcttccctg tcccgcatat 2443621 ttcaaatgaa ttgggctgcc gtgcgttttg ttgtactttg taatataatc tgccgcattt 2443681 gacgtggcgc caactatgac tgtttttccg tgtaagtctt ttaatgtatg aatcttgtga 2443741 ttatcctctt tcaccgtgat gtacatcggc gagtagttat atgggacttt atgatacaaa 2443801 aaacgctttt ctcgttcttt atttttggcc atattgtgcg caatcacatc aattttttta 2443861 tttccgagac tcgtcagcaa atttgagaaa tccatcgttt taaattcaaa tgtatattga 2443921 ggcaactcct tatcgatggc tttcatcact tcaatgtcat acccggtcaa ttcacctttt 2443981 tcatttaaaa acgcaatatt cggaaaatct gttccagtgc cgactatgac cgtttgagcc 2444041 tgacgatctg ttttgttatt tgtttgcgaa catcccccgc caagtaatgc aaacactgac 2444101 agcagcaaaa ccaatccttt acgcttattc ataggctgcc tcacatcatg cccagctggg 2444161 cgcacctaaa agcgttgggt taaatcgttc cggaatcaga accttgtgca tcatcacacc 2444221 tatgtccccg tctttttcct gctcaaaata cacttcatac cctctccttc tgtacatgtc 2444281 agcaagccaa ggatgcttgc gcgccgatgt gccgagtgtc agcgcaggag ccttcagcat 2444341 atctcgaagc actttttctt caacatacgt aagcagctta cttccggcgc cttgcccttt 2444401 atattccggc agtgtcgcaa accaccacac aaatggatat tttgaaggag gcgtctcact 2444461 ctcccacggg aacctgattg taatcgttga aatcagcttc ccatcccgct ccagcacaat 2444521 cgctgaatga tgttcaatat tttctgatac catttggata tcagctctcg tggatggcca 2444581 atcaatatcc agctgccgaa tgggctgaaa tgcgctgtta accagtttca acagctccga 2444641 tgcatcttca acagttgcca gtcgaaaaat atcatcactc atttttgtca ctcctcttca 2444701 caaaatatat aattcctatt tgtttactaa gcttttattg tttatactat aaagcatact 2444761 ctgatctttg actaatcaaa aaaagtaaac cttcacttca gtaattttaa tgatgaaaaa 2444821 caggagggag cacattggag ttacgctcaa tcaaaacgtt tcatacgatt gtaaaatttg 2444881 gaagcttcta taaagctgca gaaatactca actactcgca gccgacgata tcgatgcgta 2444941 tgaagcaatt ggagcaggat ttaggcgtac tgctgtttga aagaggaaaa agcctgcagt 2445001 tgacaaaagc agggaagctt ttttatgaac gaacaggaga tcttttgatg caatacgagg 2445061 cgcttaaaca caacctctcc gacttaaagg aagaagaggc aggcattatc aacatagggg 2445121 tttcagagcc aaccgccagt ctgatattcc ccgagatttt aaaggatttc ttaatggatt 2445181 acccaaagat aacggttaat atcaaggttg atgacgccaa tacctgcagt caaaagctct 2445241 tagacgggac gattgatttt gcagtctgcg gcgagccgga gctgattctt gaaaattact 2445301 accatccatt tttttatgac acattaaatg tgattgtatc tgatcaacat ccgctcgctg 2445361 agaagaaggc tgtccatttg tctgatttag cagaagagcg cttcatattt acgcccgcca 2445421 attgccccat tcgcttacaa attgaacagc atttacatag agaactcggg aatcgctaca 2445481 aaaaaatgga gctcacaagc agcatgtcac atgaatatta cgtacgtgaa aacatcggaa 2445541 tttcaatctt taccagcacc gcacattcta aaccgttcaa cggcactaaa gtcattccaa 2445601 ttctgaacct ggatatcacc ccgcccatag ggctgttgac aaatcaaaaa gaagttcatt 2445661 ttgaccgcgc cacgaaggac ttgatcgccc ggataaccaa acgttttcag cagcgcagca 2445721 aagaattgga aggaacctct gataagacca ttacaggata actgaaaaaa taaaaaccac 2445781 ctcctgattc atcaggagat ggtttcacgg tttaaagctc gatcgtctca ccgaccgaca 2445841 tgactttgcc gactccgccc ggcaggctgt cagcgaatgc ttctgggtct tgttcgatga 2445901 ccgggaatgt attgtaatgc accggcacga cctgttttgc gcgcagccat tcagcagcaa 2445961 gcttggcgtc ttcaggcccc attgtaaagt tatcgccaat cggaaggaaa gcaaggtcga 2446021 tatgattcaa ttcgccaatg agtttcatat cagagaaaag tgccgtatcg cccgcgtgga 2446081 aaatcgtttt atcttctaca gtcagcaaaa taccggcagg catgcctgtg taagtgatcg 2446141 ttttgttttc ttcatctgtg atggctgatc catgaaaggc ctgtgtgagc ttcacttttc 2446201 caaaatcgaa ctggcgggag ccgccaatat gcattggatg aacattcaag cctttccagc 2446261 ctaagtacac agcgagctcg ttcggggcta taaccagcgc gttattttgc ttggcgattt 2446321 gttcagtatc accgacatgg tcattgtggc cgtgcgttag taagatgaca tccgctttta 2446381 catcctccgg ctttatatcc gttaatgaat tccctgttaa aaacggatca aaaataatat 2446441 gatggtcctt cgtttccact gtgattacag aatgtccgtg atatgtcact ttcatttctt 2446501 tcacctcgtc acatgatttt gtttttttta ttttcccttt ttaaaaagct gaaaaactta 2446561 tgttgtttga ttcttgttaa tgacattgag gcctccggtg gcttcaatga cagtccctgt 2446621 cacaaggtct gagttctcct cacacaagaa agcgataatc ctggcaatat cctcgcctgt 2446681 accggatctt cctatcggcg ttttttcttt gccgattcgc attctggctt cctctatcga 2446741 tgcttctttc atgtcgccga caatgtctcc tgggcaaacc atgttggcgg ttatgccgaa 2446801 ttcggcttct tcaatggcaa ttgtcttcgt caaagaagcc aagcccactt tcgcagcgcc 2446861 aaatgccgat cggtgaagcc agccgggcgc gtgagccgca ccttggaatc cgtacgtaat 2446921 aatgcgtcca aattgctgtt ttctcataat aggaataacc gctttgaata aatgaaagac 2446981 ggcgcttaaa tttccttcca gcatgccata ccattcatca tcagtataat cggctaactt 2447041 tttacgttca aatatgtatg gtccagcgtt gttaatcaaa aagtcgatcc ttccgaagcg 2447101 gtttaaggca gcctctgcaa tacgcagcag atcttctttt ttggtgacat caccttttac 2447161 aaattgcagc cggtcaagac aatcgggaca ggcttccttc aggcggctga ctgcctcctc 2447221 atcctgtctg taattgactg ttactgaata cccctttgca agcaacgttt cagtcacttt 2447281 gcggcctaaa cccttcgaac cggcagtaat taaagcatgt cgcacatgaa tacctcccaa 2447341 agcaacgtcg ccgctttcaa taaagtgttt cttcttctac tttactataa aaggcttgca 2447401 atatcacttt ttacactttg gcatacaaaa aaagctgcct gtacagacag cttattctgc 2447461 aggagatgaa gactcctgat caggcatatc gacataaccg ctttgatatg cttctgaaat 2447521 gagccttgtt gtctcctggc tttcttgttc atcataaata tagcgttccg gttctttttt 2447581 catcattctg cctcccatca ttatagaggt aggttggcta taatgacggg attttatgaa 2447641 ggaaatttta acaaactcct gctgccacgc aagctttcgc tttttcaagc gcctgttcca 2447701 cctgtttgaa tccggtgccc ccggcgctca ttcttttttc aactgcgtag taagggtcta 2447761 acacagtgta aatatcttct tcaaatagtg tgctcgcctg ctgaaactcg ccaaacggca 2447821 tatcgcttaa atagatccct ctttcgatgc atgtgtacac aagtttcccg accacttcat 2447881 gcgcttctct gaacggcatt ccttttttag ctaaataatc ggccagttcc gtcgcgtttg 2447941 aaaagtcttg ttttgttgct tgcttcatga cgtctttgtt tacagtcatt gtttggatca 2448001 tgcctgtgaa gatttgcagg ctgccctcca ccgttttcac cgtgtcaaac atgccctctt 2448061 tgtcttcctg cagatctttg ttgtaagcga gcggaagtcc tttcatgatc gtaaacagcc 2448121 ccatcatatc gccgtatacg cgtcctgttt tgccgcggat cagctccgcc atatcagggt 2448181 ttttcttttg cggcatcatg ctgcttcctg ttgcgtacgt atcgtcaagc tcgatgaatt 2448241 taaactcctg cgagcaccat aaaatgattt cttcagagaa acgggatagg tgcatcatca 2448301 gcatactgct gttgcttaaa aactccaaaa tgaagtctct gtcgctgacg ccgtccaagc 2448361 tgttttcata aatggcatca aagccgagca gttccgctga ataatcacgg tcaattggga 2448421 aggttgttcc cgcgagcgcc ccgcagccga gcggagattt gttaatccgc ttcattgaat 2448481 cctgaaaacg ctccttgtcg cgctcaagca tccagaaata cgcaagcaga tggtgagcga 2448541 atgaaatcgg ctgggcgcgc tgcaaatgtg tgtagcccgg cagaatcgtt tcaacgttcg 2448601 cttccgcctt ttcaatcagc gcactttgga atgcctcaat cagctcgatg atgtggccga 2448661 catgattctt caagtataaa tgcatgtcag tcgccacctg gtcattccgg cttctgccgg 2448721 tatgcagctt gccgccaaga ggaccgattt cgtcaatgag cattttctca atgttcaaat 2448781 gaatatcctc ataatcgact gagaattcca atgctccctc ctctgctttt tgcaaaaggg 2448841 tattcaggcc ctctcggatt ttcaactctt cttctgctgt cagaataccg cattttttca 2448901 gcatggcagc atgtgcgaga gaccctgtaa tgtcttcagc aactaaattt tggtcaaatg 2448961 atatggacgc gccgaactcg tcgacccatt tttccggtgt tttttgaaat cggcctcccc 2449021 aaagcttctt catgctttaa tctgctcctt ctttttcacg atgctgttca cttttgtcgg 2449081 aagtccccaa agctcgataa atccgattgc tgcatggtga tcaaatgcat cgtcttttgt 2449141 atatgttgca agtttttcat catatagaga gtattccgat ttacgtcctt ctacaattgc 2449201 atggccttta aacagcttca cgcggacaat gcctgtgaca tgcttttgcg tttcttttaa 2449261 gaaagcgtgc agcgcgtctt ttaacggtga gaaccataag ccgttgtaaa tgatttctga 2449321 cattttttgc tcgatgatcg gtttaaagtg ggctacctct ttcaccagtg tcaaatcttc 2449381 taattcttta tgcgctttga tcagtgtcat cgcaccaggg cattcgtata cttcccggga 2449441 tttaatgccg acgaggcggt tttccacgtg gtcgatacgt ccgacaccgt gcgcgcccgc 2449501 catttcattc agcttcaaga tcagctcaga aagcgagtag gaaacaccgt caatggagac 2449561 aggcacgccc tgttcaaatg caatttcaat cacttccggc gtgtccggcg ttttttccag 2449621 cggagctgtt aaatcgtatg caccttctgg cggcgccgcc catggatctt ctaaaatgcc 2449681 gcactcattg gcgcgtcccc agaggttttg gtcgatagaa tacgggctgt caagattgat 2449741 cggaatcgga atgccgcggc tagccgcata ttcaatttct tcttcacgtg accactgcca 2449801 ttcgcgaacc ggcgcgatga cttctaggtc agggtttaat gatttaatgg agacttcgaa 2449861 acgaacctgg tcatttcctt tccctgtgca tccgtgggca atcgcctgtg catcttcttt 2449921 ttccgcaatt tcaaccagtt ttttcgcgat cagcggtcga gataatgccg aaacaagcgg 2449981 gtattttcct tcatacattg tgtgggcctg caaagagata agcgcgtaat cctgtgcaaa 2450041 ttcttctttt gcatcgatca cgtaggagtt tgtcgcgccg acttcaagcg ctttctgctg 2450101 aacaaatgcc aaatctttgc cctcaccgac atccaggcag caggcgatta cattatatcc 2450161 ttgctcctga agccatttta ttgcgacgga agtatcaaga cctcctgagt atgctaatac 2450221 gacttttttc tgttctgaca tgataaaaat cccctctcaa ccgtgtttct attttgtata 2450281 aaaataaatt atatttaata aaaatacatt ttgtatgtat acactttaac aagtacgttt 2450341 cgttttttca agccttttat aaaaaaaact tcacctaaat ttcaggtgaa gtttcatagt 2450401 atttattcat ttacttgtct tttctgattt ctctgaccac atgcgcaagt tcgggaataa 2450461 tcagcttatt cattgccagc tttactgcgc cgcttgagcc tggcgttgag aaaacagcgg 2450521 tatgctgaat gacgccggca gttgctctcg acatgattgc ggcagagccg atatcctctg 2450581 tataactcag catcctgaat atttctccaa agccgggcag ttctttcgaa aacagcggcg 2450641 ttatggcttc aattgtgaca tcccgatctg ctatgcctgt ccctccgttt aagagtaccg 2450701 cgtctgtctg ttcatccatg cagcccgcaa gcactgaccg ttgcaaagca tccttttcgt 2450761 cttttacaat ttcatatgcg gcaatatgat gaccggcttc ttctaaaaat gagatcatca 2450821 gcttgccgct tttatcggtt tcatctgtcc tcgtgtcact gacagtaatc actttgcacc 2450881 gaacgatatc gggagcttct tgtttatgct cttgaacgct cattggccca cctcttttat 2450941 gttttctgtc tgtcactatc atgcatcaac aaaaaagcac attcaagaga atgtgctttc 2451001 atgcgattta ttttgctaaa cgaacaacgt cgcgcgcaat catgacttct tcatcagtcg 2451061 ggatgatcat gacttttact ggagaatgcg gatagctgat gaaagcttcc tcgccgcgca 2451121 cgttattaag cgcagggtcc cagtatacgc ccatgaattc taaaccgcga agaacgcgtt 2451181 ctctgacttc cacactgttt tcaccgatac cggcagtaaa gatgatcgca tctacaccgc 2451241 tcattcttgc agcgtaagaa ccgatgtatt tgtggattct gcttgcgaat acttcaagag 2451301 ccgtttccgc gcgctcattt ccttctttcg tagcttcaac gatgtcacga agatcgcttg 2451361 agaaaccgga aatgccgagc agtccgcttt ttttgtttaa tgtattcagt acttcgtcag 2451421 ccgtttggcc tgttttctcc atgatgtatg ggatcagggc agggtcgatg tttccagagc 2451481 gtgtgcccat tgctacaccg gcaagcggcg taaagcccat ggatgtgtca atagattttc 2451541 cgccttcaac agcggcaata cttgctccgt ttccaaggtg gcaggaaatc aggcgcaagt 2451601 cttttaacgg acggccgaga agctctgccg cacgctcagt tacatattta tgtgaagtgc 2451661 cgtggaagcc gtatttacgg atgccgaatt tttcatagta ttcatacggc aagctgtaaa 2451721 ggtaagactg ctcaggcatt gtttggtgga atgctgtatc aaatacagct accgcaggaa 2451781 catttggaag cacttctttg aacgctttaa ttccaacgat atttgccgga ttgtgaagcg 2451841 gtgccaattc agaaatatct tcgatttcct taatggtttc atccgttaat aaaacagaat 2451901 cgctgaattt ttctccgccg tgaacgacac gatggccaat tccgtcaatt tcattcaagt 2451961 ctttaataat gccgaattcc gttaacttat tcagcagcat tttaacagct accgcatgat 2452021 ctggaatatc agttacttct gtattttttt cgccgttcac agaaattgtg aatacgctgt 2452081 cggcgatacc gattcgttca actaaaccct tcgttaaaac ggtttctgaa ggcatttcga 2452141 aaagctgaaa tttcaaagac gagcttcctg cgttaattgc aataattttg gacatgattg 2452201 acgctccttt atactctgta tcaacaactt cgtttttcgt acttttttcc cggtgaatat 2452261 caacatcttc tccgaaaaat atctgacttt tccatttaaa cattgtcatg tcggcttttc 2452321 aagtcaactt gcgtattgat aacgcttaca ataagaagtc gttattttca gacacattca 2452381 ctataggttt tgtattgatg aacgcttaca atttgcggtt tttccctctg tattttgtgt 2452441 ttcaaagctg gattcaattc gtcaagtccg gtcttcaaaa gcataaataa aagcagctta 2452501 ggcatcgacc tcatacggct gtctaagctg cttttaaaac acttactttt cttttttaaa 2452561 ccattcatca aattgagcca tcatatcaag catcgccttt tgattggaga aagacggaag 2452621 attcgcaagc agaatttgcc ccggcgcttt cgtattctct ccttgtttct gaagcacaag 2452681 gatgcttttg gcatgagctt cgtctttaaa aatagatttt ggcagctgca acagtgcgtt 2452741 gatatgaacc ttatctttga aaaactgttt cagcttgccg ctttgggagc tctcaaacaa 2452801 atgattcgga atcataaaaa ataagtagcc gcccggtttg gtatgcttga cgctctgttc 2452861 aataaacaga tgatgagcga aggaatggcc ttcgtcagct ttgagctcaa acgcttctgc 2452921 tccttcgtca ttcggataat agccgactgg cagatcacaa atgaccgtgt caactggatc 2452981 gataaacaac ggctcaaggc tgtcctggtg gaaaagctca agctcttttt tcagaaggtt 2453041 cgcttgggca taggcgatct tcaagagcac atcatcaatt tcaatgccaa agctgtttgc 2453101 cgttttttca gacagctggt tcagcacggt aaacagaagg ttcccagttc ccagggctgg 2453161 atcaagaatg gtcagttcct ttttgtccgc cataaattta ttcaccaaat agctgatgaa 2453221 aagcccgatc gtatccggcg tcatttgtct gtttggatgc gagatatctt tcattccttt 2453281 aaggacggca agctgaaaag ccttgcgtac ccactcatgc tcatacgtgc cgaattccgc 2453341 tttttcaagc agagcctgaa gttgtttggt tttctgatca gcaggcagtt tcagctgatc 2453401 cgttttttca agaaaataca tttctcctgc ttcggccagc gcctctatat atgaaatctg 2453461 caattcattc tttatcataa tcgcggcttc gtttaacagc tcatacaccg cacctacatg 2453521 gtctttttgc atattgtgtt cctccttgcc atgaaaaaag ctccggcggc agcctggagc 2453581 ttttttccct gcttacttta ctaatgcctt agcagcctca attggctttt catagttcgg 2453641 gtggtttgtt gcttcgctta catattcagc gtaaacgact tttccgttct catcaaggac 2453701 aaatacggaa cgcgcaagca gacgaagttc tttaatatac acaccgaacg cttcgccaaa 2453761 tgacatatct ctgtggtcag acagtgtttc cactttgtca attccgttag cgccgcacca 2453821 gcgcgcttgc gcgaatggaa ggtctgcact gattgtgtag acgttgacat ctccaagctt 2453881 tgcagcttct tcgttaaaac ggcgtgtttg tgcatcacaa acacctgtat caattgaagg 2453941 gataacagaa ataatcgtta cctttccttt catgtcagct aacgattttt cttcaaggct 2454001 gttagtcagc actgtgaaat caggagcttg atctcctacc ttcacttctt gtccgacaag 2454061 tgtaaccgga ccgcctttga atgtaatttc agccattata attcctccct tttgtatgta 2454121 tgtctctatc atagtaaagt ttcctgcaaa ctgcaaagtt tatgccaaaa aaaagttaac 2454181 tgcggccagc gcagttaacc tttttttaat aattcatatt gttcatttgg ttttgatttt 2454241 ggccttggct ttggtttttg ttatttttct tgaacatttg ctggatgcgc tcgagtgttt 2454301 gaggggctgc gtctaaaatt ttctctatta aatgggtatt ttcatctaaa tgaagcattc 2454361 tgatgcctgt cgatccgaca attaaaaacg cgatcggcgt aatggacaca ccgcccccgc 2454421 ttccgcctcc gaaaggaagt ttctgttctc ttgtctcatc gtcttccgat ttcttttcgg 2454481 ccggctttcc gccaaactcg cttccgcctg cggcgaatcc gaatccaact ttagaaacag 2454541 ttaaaatcac acttccatca ggcgtttcca ctggatctcc gatgatggtg ttaacatcaa 2454601 tcatttcctt caagttttcc attgcggttt tcattaaacc ttggatggga tggtctgcca 2454661 tatacgcttc ctccttaaac tgatgaatca ttctttgaag tcattctagc cgacggattc 2454721 ttctttaata cggatagctc ccgtccgtat ttgacgaatt tgaaagctgc aagcatagca 2454781 tgtccaaagc gaaaaaagaa tatacactga aaatgggtct tggaaacagg gacttgaaac 2454841 gacgggatca cctcatagac aggtttattc acaaagtcca ggtggtcgta gagcattgct 2454901 gcgataccgc ccttcacgcc ccatacagca ccggttaaca cacctgtcac tgccgcgtcc 2454961 tgaattccga ttactgtaac ccattctagt tttgtgatat gtaaatgcgc gagaaaagac 2455021 gcgctgattt tccgcagtct ggtgacctga tgcaaaagca tttcgatttt attaatgctt 2455081 tgctgcacat cgttttgtgt aatttttttc tttccgctgc tttttttcat tttggattca 2455141 gttttttgtt tgatatccac tgttccgtct tctttgttca ccttaatcgc cgggattgtt 2455201 tttttgatcc ttataaggcc aaacagcgcc gtaatcttca aggtcaattt gtcattatca 2455261 tcggcatgaa gatactccag cgcgacatgg attttcattc tgagaagcag tacgatccct 2455321 atgagaataa gaatggctgt cagtacatac accatattct tcacttcctc taggagcatt 2455381 atcgccaatt cctaaaaaaa taaacccgga cggaagtccg ggttatcggt tatttgcggt 2455441 ataatttttc atgcaccacg gtggtatccg cgatgtaatc atgaatccct tgttttgtag 2455501 gtgaaaaggc aacaacgata tataaaatcc aaatcttatc aatataccgt ccaaccactt 2455561 cacgaaaaat cactgtactc catgtcagct tgctatcttg cttcacagaa accactttga 2455621 ggccgaacac cattttacca agcgtctgcc tgaagtattt tgtcatgagt gcgaaatagg 2455681 caagatacac aataagcgtt gtcacactgt aggccgagaa ggtaaacatg ccggatgttt 2455741 tcggcagatc caatacggta aagaggggag aaacgagcaa atggtttaat ccccatatca 2455801 cgagccaatc aagcaggaaa gcccagaaac gaacccaaaa gccagcatag gcatgtgtca 2455861 gcagctccgc ttcttgcggg cctttgatgt cattgcgctc taactcttca tatgtcgcgt 2455921 ccattattgt tccctcctac ttcgcataga gatacatcat tctcggcgaa ccggattgcg 2455981 atagaatttc tctcatattc aaaaaatcaa tttcactttt aaacattttg ttcgcgccca 2456041 tggaaaacag tgagcctaat ccgaagcttt cctcataaga aatgacagag gcgtttttca 2456101 aatccttgtg atcctttttc atggccgtaa tggtatcgtc ataaaaacca agctcatcaa 2456161 cgaggttcag ttttttcgcc tgccgtccgt catacacgcg gccgtccgca attttcttta 2456221 cctctgcttt cggcatgccg cgcccttttg aaatgacatc aacaaagcct tcatacgaat 2456281 tatcaaccat cgattgcatg atgttttttt cttctttcgt catctcacgg gaaggagaca 2456341 taatgtcctt atgggccccg ctcttaatcg tttcaaaaga aatgccaagc ttgtcggcaa 2456401 gctttgaata attgacgctt tccataatga cgccgagtga cccggtcagg gtttccggtg 2456461 tcgcaaaaat cttatcagcc gctgttgaga tgtaatagcc tcctgatgct gccatcgaac 2456521 ccattgacac gtaaatcggt tttttcgttt ctttcttgat ttcttccagt ttcttatgta 2456581 tttcagcact ttcatacact ccgccacccg gagaattcac cttcagaacg atacctttga 2456641 ccgtcttgtc atcttttgcg cgctcaaggt tttttaagaa cgttctgtgg ttatatccgt 2456701 ctgcaccaag cagactgctt gagtccccat tatcctgaat ggtgccgctg acctctaata 2456761 cggcaatttt acttgaggga ctgccgtttt ccagcgtctt ctcctgcgat tcatccgtca 2456821 gtgatgtgag atccgtttga gcgcctttga cgctttcaaa gaaactcata gagatgctga 2456881 cgataataga cacgccgaaa atccccagag caatcactaa tgcaatccat ctttttgcat 2456941 tcattttttc tcctcctttt tcctaaactc tctcattata cgattcaata tgaaaaatgt 2457001 ttcacttcat gagaaagctc cggcttaacg ggctgccggc aaacgtggta cacttatggc 2457061 caaaggtatt ttatcacaaa tactggatgg cagaaaaact taaatatgac agcaaagggg 2457121 aaatgggata tgaccgatca acgccgtaat gtttattttt ttcacaaaca ggatcaggaa 2457181 acgaacgaac aagcccgctc gttaacacaa ttagcggaag agcatggatt taccgttgtg 2457241 aaccagcact cagacgccaa tattatcgct agcattggcg gggacggcac atttttgcag 2457301 gcagtcagaa agacgaattt tcgtgacgac tgcttgtacg tcggcattac caaaaagggg 2457361 aaagctcatt tatattgcga ctttcatagt gatgagcgag aaaaaatggt cgatgcaatg 2457421 acgtttgaac aaattgaagt gagaaaatac ccgctgattg aagtgacagt ggatcaagcc 2457481 agtccttttc actgcttaaa cgaggtatcc atccgctcaa gcatcatcaa aacctttgtg 2457541 atggacgtgc tgattgacga tctgcacttt gaaacgttta gaggtgacgg aatgattatc 2457601 tcaacgccta cagggagcac cgcctataac aagtctgttg caggagctgt tgttgatcca 2457661 ttgcttccat gcatgcaggt atcagagctt gcatccctta acaataatac ctaccggaca 2457721 ctcggctcgc catttgtcct cagctctgac cgaaagctga cccttcgtgt ggtgcaggac 2457781 ggcaacgaac acccaatcat cggcttggac aatgaagcac tcagcacgag aaatgtgaaa 2457841 acgatcgaaa tcaaactgtc taataagaaa atcaaaacag tcaaactaaa ggacaattca 2457901 ttttgggaaa aagtgaagcg tactttttta tagaaaataa aaggacaggc tgctgcctgt 2457961 ccttttatga tttctcatat acaatctggc cgttaatcac ggttttttta atctctaaaa 2458021 gatgaagctg tgcggggtca atggcaaacg gatcaccact gagaactgta aaatccgcgt 2458081 catagccttc cgcaattttt ccgcgtgact tctctttata aatgataccg gcgctacctt 2458141 ctgtataaag ctttatcgct tcatatacag gtaaacattc actttcatta tagcttggcc 2458201 cgttttgctc atgactgctt ttccggagga ccgcggactg gatccctaga agcgggtcaa 2458261 caggctcaat cggggcgtct gaaccgcccg cgcataaaat gcctttagat atgagggttt 2458321 tccaggcaaa tgcagtcttc atccggtctt ttccgagacg gtcaatgacc cacggaaagt 2458381 cgcttgcaac gaagtgcggc tgaaggtcaa gtgcgatcgg catgcgtgct gctctctcga 2458441 ttaattcgtt atcaagcact tgagcatgaa taagccgatc atgccggccg tttttgggcg 2458501 gatgcttttc tattgcgttc agcacttttt caaaagcaag atcgccgatt gcatgaacag 2458561 caacctccat ccctttttct ctcgctttgc gaatgagccg gccaagggtt tcgtcatcgt 2458621 gaacctgaac accatttgtt gatggatcat cctgatatgg ttctttcaat aaagccgttc 2458681 tcccgccaag cgccccgtcc gcaaagattt tcatagcacc gaactccaca tacgggccgg 2458741 acagcttctc cagctgctcc catcgatcga cagcttcatg atgaacgagc aaatggcagc 2458801 gaaacggata ctttccgcca gcggcagctt tctcataagc tttcatcggc accgaaacat 2458861 caccataata ggacaagtct tccgaatgac cgcccgtcag gccttttgtc cagcaatcct 2458921 ttattgcagc cgttaatgcc tcatcaacat agtgctggga gactggcggg acagccttca 2458981 gaatcaaatc ctgcgcctta tcaaacagga gtccggtcgg ctcgccattt gcatctttta 2459041 cgatgactcc gccgtcagga tcaggagtat ttcttgaaat tcccgctgct tgaagagccg 2459101 cagaattgac agctattgca tgccggcata tacgcttgag caagacgggc ctgtcaggaa 2459161 acaggcgatc aagatcatgc ttagtcaagt agtcaggtgt ctcaaactga ttttcattcc 2459221 agccttctcc aatgagccaa tcgtttttag gaagctgccg ctctctttcc ttcgcagcct 2459281 gtaaaattga atctttcgac gtcagtgcgg acagatcgag ctgaagctgt ttctcaccgt 2459341 ggccgatcaa atgtagatgg ctgtcaacaa aaccggggaa catcactgct ccgttcaggc 2459401 tgatttcttc tgtttccggc gacccgtact tttccttcaa acgttcatag ctgccggtgc 2459461 cttttataac accatcctca acataaactg cctcagtccg atcgccttct tcgagcatcg 2459521 tataaatgaa accgccgtgc catatcgcct tcattcacgt tcactctctt tctttacgcc 2459581 tttttattgg ctttgagctg ttcttcacgt tttcttaatt ccactcgtct gatttttgca 2459641 gaagccgttt tcggcaggct ttccacaaat tcaatttctc taggatattt gtatggagcg 2459701 gtaatcgtct tcacatggtt ttgcagcatt ttgacaagct catcactgcg tttttcatga 2459761 ttttgcagga caacatatgc ctttacgatg gagcctctga tttcatcagg gcttgcgaca 2459821 acagcacatt cttttacttc tgggtgctta acaagcgcgt cttccacctc gaaaggcccg 2459881 atcgtatagc cggagctgat aataatatcg tcatttcggc tttcaaacca gaagtaacct 2459941 tcctcatctt ttcttgctct gtctcccgtt aggaaataat cgccgcgaat ttgtgttttc 2460001 attctttccg gatctttaaa atactcttta aagagcgcag gcgtactgag gtgaacagcg 2460061 atatcgccaa cctcaccagg tttgcagatt tcaccgtctt catttatgat ctccacctga 2460121 tttcccggtg tcggttttcc catgcttccc ggtttaatag gcgtatcttt caaaacacca 2460181 accaaaagcg tgctttctgt ttggccatat ccgtcccgta ccttaatgcc aaagtgcttt 2460241 tggaaaacat caatgacttc acggttgagc ggctcacctg cggaaacagc gctgtgcagg 2460301 gcagaaagat caaagcgttt caagccttca accttcgcca ttaagcggta ttctgtcgga 2460361 gtgcagcaga aaacattgat tttgtagcga tttaaaagct ctagatattt ttctgctttg 2460421 aatctgccgt ggtacacaaa accggttgct ccgctgccaa gcaccgctaa aaacggactc 2460481 catacccact tttgccagcc aggggcagca gttgcccaga cgatatcctt ttcagaaatg 2460541 tcaagccaag cgccggcaga agtttttaaa tgagcaaatg cccatccatg tgtatgtaca 2460601 acacctttcg gctgacctgt tgtcccggat gtataagata agaaagccat atcatctctt 2460661 gttgtgtcag ctgttttaaa ttggcttccg tccgcttcaa ttgataagag gtttttccag 2460721 ccggcatcat tttcaccaat agacagtgta atcagtttgt cagccgtact gacatcccgg 2460781 aaagcgccaa taaattcgga gtagacgata gcgcctttta cctctgcatg ttcaatccgg 2460841 tattcaagat ctttcgcgcg aagcatttcg gagcacggaa tgacaaccat tcctgatttc 2460901 aggatagcca aataaacagc ataggcttca agcacccgcg gaaccattac aatcagcttg 2460961 tctccctttt taaatccaag atcagctaag gccgctccga ttttatttgt ttcttccatc 2461021 agcttttcat acgaccaaga ttcttgcttg cccgactcgt cctcccaaag aagagcggtt 2461081 ttttgtccag cagcactgaa cttttccatt tcattcacta aattatattg cacaggggca 2461141 attaaatctt cacgttttaa cacgaacaac tcctcacttt ctccacccat tatacataaa 2461201 tacaggctct ttccgtaagg atatgcctaa aagcaacctc tgtaaacata gattttatag 2461261 gccgctggtc cttttttata tgtaaaaaat gaaaaagagt ggggataccc ccactcctaa 2461321 gccattatgt gaaattgtaa attagaattg tcctccgccc atgttttgtt gagcaaaaga 2461381 tacaagacgt tttgtgatct ctcctccaac agaaccgtta gcgcgagaag ttgtgtctgc 2461441 tccaaggttt acaccgaatt cagaagcgat ttctaatttc atttggtcga tcgcttgagc 2461501 agctcctggt actaaaaggt tgttgctgtt acctgagtta ttgttagcca tgtgtctcac 2461561 ctccttgtga gtatagaatg tgtcaaaaca catggcttca ttcagaaaaa ctttggtaat 2461621 tgtatacagg agctgaaaat tgatttaaaa gagttcagcg aatttatcgt tagcttcttg 2461681 ttcgctataa agggtcattg tctcaatgtt atctaccgct tcttgaatat acggctcgaa 2461741 atcaacaaag ctttcaaagt gttcaatttt ctctttttta gggcgtgttt tcgggcttgg 2461801 cggtgtaaag atcgtgcagc agtcttcaaa cggctgaata cttgtctcat atgtgccaat 2461861 ttcccgtgat ttttcgatga tttctgtttt gtccatggcg attagcggac gcaaaatcgg 2461921 tgttgacgtc accgcattaa ttgcatacat gctttcaagc gtttggctcg ctacctgacc 2461981 gaggctttct cccgtaataa tggcaagccc gtttctcttt tctctgattc tgtcggctat 2462041 ctgaagcatg aggcggcggg ttgccgtcat tgtgtaattt tcaggaattt gtttttggat 2462101 gagctcttgc gtttttgtaa atggaacaat atgaagtgtc atgcttcccc caaaacggga 2462161 cagacatttc gccagatcca ttaccttttg ctttgcgcgc tcgcttgtgt atggcgggct 2462221 gaagaaatga acagcttcta ccgacaatcc ccgtttcatc gcataaaaac cggccacagg 2462281 gctgtcaaaa ccgccagaaa gcatcagcat cgcttttcct gctgaaccaa ctggcagccc 2462341 gcctgcacct ttttcatcac gaattgtcaa aaatgttgct tcttccctga tttcgattct 2462401 gagcgggatg tctgggttgc gaacatcgac cgtcaatcct tctgtatttc gcaaaatatg 2462461 gccgccgatt tcagcgttca tctggtttgt atctaattca aattgcttat acgctctctt 2462521 tgtcgcgact ttaaacgtat cacctggttt atactgatct ttgatagcct ttagtgcggt 2462581 tgccttaata tcatcaaggc ggctgtcaca cttaattgcc aggctgaagc tttgaatccc 2462641 aaacacttgc tttaaatgag gaaaaagagc ctcaggatcc tctccattta atgtaatcgt 2462701 catacgatcc ctgttggaaa agtattttaa attcggatag tctttcaaaa cgagtctgat 2462761 gttttgtttt aagcgctcaa taaagctttt tctgtttttg cctttggtcg aaatttcccc 2462821 aaaacgaatt aatatatgat cgtaattcat gttctacctc atcatttccc ttaatttttt 2462881 gatgccagga cgaagcgcgt tcataaacgg ttctgccaca tcgcttgtct ggctgtaatt 2462941 taaactgatt ctgatgctgc ttccggcaat ctgctctcct ttgcccatct ctaagagaac 2463001 cttgctgggc ttatgttctt ttgccgagca agccgatgtt gtggagacga atatatcctg 2463061 ttcctcaagc atgtgtaaaa gcacttccgc tttaatcccc ggtacagaga aattaataat 2463121 gtgcggcgcg ctattcattt gaggcgtgtt gataacgacg ccctcaattt cactcagcct 2463181 attcataaac aattccttta cggcagtcat cgtgtcaagc cgtgtgtcaa aatcagcaga 2463241 ggccagatta atggccttgg caagcgaaac cgcaccagca gtatgttctg ttccggcccg 2463301 tatgcctttt tgctgagagc ctcccgttat gagcggaata aggcgtgttc cttcttttac 2463361 aataagtgcg cctgtcccct ttaggccgtg aaatttatgc cccgaaattg aacatagatc 2463421 aatgccggcc ttttcaattg ccaagggcac tttatagatg ccctgcacat aatcgacgtg 2463481 aaacaaaatg ttcgaatgct ctttcagcac ttctcctgcc gcttcaatcg gctgcacgga 2463541 accgacttca ttgttcacat gcatcatgct gacaagcacg gtatcgggac ggatggctgc 2463601 ttttagatct tcaatagaaa caaatccgtc ttcattcaca gaaagataag tgatatcaaa 2463661 cccgaacaac tctttcagct gttctaacga ttccgtaacg gatggatgtt caatagaagt 2463721 ggcaatgata tgtttgcctg tttttatctt tgacaaagcc gctcctttta aagccgcatt 2463781 attggcttct gtggcgcctg acgtaaatac aatatcatat ttttttaggc ctaaggacct 2463841 tttgatttga tttttggctg cttgaagcag ctgttccgtt tcggctccat atcggtgcaa 2463901 agatgaagga ttgccaaagt atcggctgct cgtctgttca tatacgttca agacttcatc 2463961 gtaaggcttc gtcgttgaac tattatctaa atatatcatc ttttttactc ctttatgaaa 2464021 gcggtacaag gtatgatatt tatgttacca taacaaaatt taatagaaaa ttacgaaaaa 2464081 ctagtattga cttctaattt ttttaccata taataagatt tgttcgtttc gtcatattat 2464141 ctgacaatta attgacagaa tattttaaca taattattag gaggattttt ttcatgaaac 2464201 actcactgcc tgtcaaagat accattatta ttggtttcat gctatttgcg ttattctttg 2464261 gagcaggaaa tatgatttat ccgccggaac ttggacaagc agccggacac aacgtctgga 2464321 aggccatcgg cggattttta ctgacagggg taggcctgcc gcttctcggc attatcgcca 2464381 tcgcattaac cggtaaggac gctaaaggcc ttgctgacaa agcgcaccct gttttcggca 2464441 caatctttac tgtcgtgctt tatttatcaa tcggaccatt attcgccatc ccgagaacag 2464501 gaactgtttc atatgaaatt ggcgctgttc cgtttttgac tggtgtacca gaaagacttt 2464561 ctttattaat atttacactt atctttttcg gcgttacgta ctatttagcg ttaaacccat 2464621 ctaaggttgt ggatcgagtc ggaaaaattc tgactcccat caaattcaca attattttaa 2464681 tcattgttct caaagccatc ttcacgccga tgggcggatt gggcgccgtg acagaagcat 2464741 ataaaggaac accggttttt aaaggatttt tagaaggcta taaaacaatg gacgcacttg 2464801 cttcaattgt atttggcgtt gtcgttgtaa atgctgtaaa aagcaaaggc gttacacagt 2464861 ctaaagctct tgctgcagcc tgcattaaag caggtgtgat tgccgcttta ggcctgactt 2464921 tcatttatgt atcccttgct tatttaggtg caacaagcac aaatgccatt ggtcctgttg 2464981 gtgaaggagc taaaatttta tctgcgtctt cccattattt attcggttca ttgggcaaca 2465041 tcgtactcgg agcagcgatt acagtcgcat gtttaacaac aagcatcggc cttgtcacat 2465101 cttgcggcca atatttttca aaacttattc cggcattatc atataaaatt gtcgttacga 2465161 ttgtcacgtt attcagcttg atcattgcga atttcggact cgcgcaaatt atcgcgtttt 2465221 ctgttcctat tttatcagct atctatccgc ttgccattgt cattatcgtt ctttccttca 2465281 tcgataagat ctttaaagaa agacgcgaag tgtacatcgc atgcttgatc ggtacaggac 2465341 ttttcagtat tttagacggt atcaaagcag ccggtttttc acttggatct ttagatgtgt 2465401 ttctaaatgc gaatcttcct ctttacagcc tcggcatcgg ctgggtgctt ccaggaatcg 2465461 tcggagcggt tatcggctat gtgctgacct tattcatcgg accatccaaa cagcttaatg 2465521 aaataagtta atgtcacaga acgcctgcgt tattgcgcag gcgttttgta ataaaaaaag 2465581 agcctgctca ttacactgcg ggctcttttt catggtcgtg attatctaag cggatatgtc 2465641 agctttgatt ttttcaactg cacctggcgc agccttttct acagcggcag cggcaatttc 2465701 ataagagtcg tcataatcaa aagcataaaa acgtctttcc gcttctttca gctgttcaga 2465761 taaaatatga ttctggcttc tgaaccggtt tccgaactga atgatttttt caatgaggat 2465821 gacctgctcg acaagttcct ctgattcccg gcttgccctg ttgacgatat cttctgcttg 2465881 tttcaaatgg gctccggctt cttccatatt taatggaagt tcgtttagtt gattgaccgt 2465941 ttcttgaata tgatgatgcg cgttctccag catctcttga atatggctcg gaatgcctgg 2466001 aatgttgcta gtcttcagca gtcttgctgt ctcagaaatt gtttttttca aattgctgag 2466061 cgtctccctc gcctgaagct cttcttttct cagcgcttgc agattttcac gatactcggc 2466121 atgctctttt ttcacttctt caatttgctt ctctattgaa gcaacttctt ctactaaaag 2466181 tgagtaggcg acatgctctg catcaagctt atctttaacg gatgatagca gctttccaat 2466241 ttcatcaagg cgcttttcaa aagcctgctg tttgccgagc tcaccggctg tcagcctgta 2466301 gctttccttc accagctcag tttccgcttt cgtatgctct ttctcttctt taagcttgtc 2466361 gtaagcaata atcaattcag gcattttgct tagtacggat tgaccggctt caacttcgcc 2466421 ctccagctgc tgataaacag attgaatatt ttcgtcaatg agctgcagga ttgcggacgc 2466481 ttcatcaata tccagttcag tcatcaggac atgttccgct cgtttcagct ggtttgacag 2466541 attttctaat tccttatcaa gctggatatg ctcaagcttg tacccttttt ctttcatttc 2466601 gccatagcca tccttgagct ttgcaatctg tccgggcacc gtctgtttac agtcagctaa 2466661 cagcttcggc acatcatcta tgtatgactg aagccgttca agattgcggt cctgctcaag 2466721 cagtactttt cgtgcagtaa tatagtttcc gccttctgtt tcttcttcaa attgtttgat 2466781 gccgctccaa atttcgtcca gatccttttc aaggctgtca taaagctccc cgtaaaggtg 2466841 gctgtaagcc agcaggtttt ttcgagattt cgaatagcgc tccctcacct gttcaatctc 2466901 ttcacggctc ttttcctcac ttgtgacaag atcgctgatt tcccgaagaa tcttttcaat 2466961 gcttgattca gccgctgtca gcaggtcgtc gatatgaacg agcacttgat tggccttttt 2467021 aaaccggtat ttgtctgcat tttcctcggc atcataaagg agctcttcaa ctttcggcat 2467081 gtgggctgtg acaatctcat cccattcttc acgccacttc tcaaagaact cttctgtctg 2467141 acccgtcatt tttaaatgtt ttattttaga catttcttcc acgatcgacc gattcagaat 2467201 ttcaatcttc cacgattcca gccggtcgat ttcggcgtag atttttttcc tgaaaaagta 2467261 gcctgccgca aacagcgcaa gcagtacaat taataatcca atgacaaact ccataatgag 2467321 cccccttgct gtttacctta atctgtcagg gtgttttatt tattcagaaa gatttcagga 2467381 tatgtattga gaaaaactgt cgttttcatt gttattatga taccatgtaa caaacatttt 2467441 ttgaccagaa atcaaaaact ttttgtgcaa aatcggcagg atttgactat tttttcatgg 2467501 ggtgacatca atgcaaaagc gagacggaca tattcacaca ccattttgcc ctcacggctc 2467561 caatgacaca ctcagacaat atgcagaaga agccttaaaa aaagggttcg aatcgattac 2467621 ttttaccgaa cacgccccat tgccgccatc ttttaccgat cccacgccgc tgaaagacag 2467681 cgcgatggcg caagcttctt tggaacgcta tattcatgaa atttccggat taaaaaaaga 2467741 atatcgcgga cagcttagca tacggacagg gcttgaagtc gattatatcg ctgaatttga 2467801 agacgaaatt acattattcc tagacacata cgggccatat ttagatgaca gcatcttatc 2467861 cgttcatttt ttgcgcacag actcttccta tctatgcctt gattatgacg agcatacctt 2467921 caaagagctg atttcagcct gcggaagcat tgaagcggta tatgaacaat attaccggag 2467981 tatctattct tccattgtag catctctcgg cgtttataag ccaaaaagag tcggtcacat 2468041 cacactcgtc caaaaattca tcaagctgtt tccatacagc atgtcagagc atattcgcgg 2468101 cctcgtttct ctgtgcctga atgccattga agaaaacgga atggagctcg acttcaatac 2468161 ttccggctta agaaaaactt acgctggcgg tatttatatc gaggattgga tgctgaatga 2468221 agcgaagcaa aagaagatcc cgcttgtgtt tgggtctgat gcccatcaag cgggagatgt 2468281 cggatatgcg tatgaggcgt ttttggaacg gtgctagttg gtgagcgcca cgtctcctgt 2468341 ccggaagacg cttctgatcc aaatcttgat ttcttcaaaa tacattttat aaaaatacgg 2468401 ctcgtgcggc tgcatgtaga gtacttctga aatatattga ggctggagat agggcatcat 2468461 caagagagat tttaattgga gaataaaatg aggcagcggc agcgttaaat attcacgctg 2468521 tttttctcct tcctcaatga tcagctggaa gatatacttt tccttcatta gatatgtcga 2468581 cataatttcc ctgattaatg tggagtcaat tgtgacttcc cggtagacaa aacgagttaa 2468641 ttgacgatga ttatgctgat aggataaaat atcgaaaacc aattgaagaa gctgttcctg 2468701 cgtgctttga gtagagatat tgcttgccgc tgtttcaagc gttttgctgt agccttcgta 2468761 aaactctgaa actaagtgtt ccatcaagcc tcctttgcct ttaaaatagt aggagatgtg 2468821 cgcaacattt acatcagctg actttgcgat ttcacggaca gacgtgccag aaaatccttt 2468881 ttggttaaaa agcatgacag cagattcaat aattttgtct ttggtgctta ctttcatacg 2468941 gctcactcct tcctcttgat actattcaag cagaaagccg ctgttcctgt aagaacttat 2469001 cgacaaatgc cggcagaaaa gccggaactt tgttttatat tatagaaaaa gtgagggttt 2469061 tccatgttcc atgtcgaaaa acaatctgga gataaagaaa aagactatca gcttctgcta 2469121 aaacagctcg aagccatgac cgaagacgaa acagaccaaa tagctaacta tgcaaatgcc 2469181 tcagcactgc tgtatcattc gctgcctgaa gtcaactggg cgggtttcta ttttgccaaa 2469241 gaagaggatg gacagcttgt gttaggtccg ttccaaggcc tgccggcatg tgttcggatt 2469301 cctttcggca gaggggtttg cggcacagcg tacgcaaacg gaaaagtgga acgtattgag 2469361 gatgtaaacg cgtttccggg acatatcgcc tgcgatgcag cgtctcaatc agaaattgtg 2469421 cttccgattc gtgtagacgg aaaaattgtc ggcgtcttgg acatcgacag cccagtgaaa 2469481 aaccgtttcg acgaaattga tgaaaaatac ttaactcaat ttgccgaaac gctagaaaaa 2469541 gcgttagcgc agtaatataa aagcccaaaa ctgatatcgt tttgggcttt ttttatttta 2469601 ttgagtcatg aatcatcaag cggtttttcc cgctccgttt cgcgctgtag agcgcttcat 2469661 ctgcctcatg cacaagctct ttcagcgact tttttgtttc tgtcgtccag caggagatac 2469721 cgcaggaaat ggttacctcg ggtttcgtat tttttctgac cgcgtaaacc agtcgctcgg 2469781 taatccgttt ccccactgca accggcacat ttggcaaata aatcgccagc tcctctcctc 2469841 cccagcgggc accgacatca tgctttcgga tgttgctttt aatcactgaa gcgacttgaa 2469901 ttaaaatctc gtccccagtc tgatggccgt acgtatcatt tacattttta aaattatcaa 2469961 tatcaacaag aataaaaaca cccttttgat ggattttcat gctgtattga attttttcat 2470021 ctaaatacgc tcgtgaatac agttcagtca gctgatctgt tttcacgaga tgctcaaggc 2470081 ggtcgcgaag cattgaattg gttacagcca gtgtcgcgtg atgaatcagc gcctgaaaca 2470141 gcttgtacat ttcaaatgta aaagcgtaca gctcctgttt caataaaacc gcaaagccta 2470201 aaagccggtc gttttgaatc atcggagcag ccatcagcga gccgtacccc gccttcccaa 2470261 aaacagactg gccattcccg atgaaaaccc ctttttcacc ttcatacagc ttttctttca 2470321 gctcattata aaaatctgac ggcttcgctt ctttaaaaaa tgctgtgctg cctgggagca 2470381 atgttaggtt ttcaaaatgg tctatatgaa aaaatcccac ttcttctgcc tgaaacgatt 2470441 ctgccattct cacagccaga tcattcattg tatcagtcaa tgtcagccgc tgattcaggc 2470501 gtcgtgatgt ttcattaatc aattccaaat ttgcgatgct tgctttggat tgttcgtaga 2470561 gctgggcatt ttcaaacgct tttcccgcgg cgtttgctaa cagcgacatt tcatcaaggc 2470621 aggcatcagt aagaaagctg tcacccgttc cttcagcctt caacaccccg tatgtgccct 2470681 gctgtccttt gatcggaata taggcgacag attcattttt ccgcaaaatg tctccggaca 2470741 aatacacttt gagcgcaaag gaatcggatt tttccccttc catatacagc tcttttgcag 2470801 gaatccctaa acattggtct tgatcgtgcg atataaataa agaaaactca aaaagagaaa 2470861 atgtgcttgt caagctttct aaaagctgct tcagcacatc tgtctgatca agcagtgaat 2470921 ggaacagctc tgtcattttg tatatctttt tttggtagat cgttttgtta tagagtcttt 2470981 cctgtttcat cgactggttt aaaaatgaag caaccacgtc cggaagccct tcaggaatct 2471041 cttcatcctg cctgcacgca agatggaaac gcctgccgga gccgtcctca atcagataac 2471101 atgaagcgtt tatttttgaa gcggaaaaac gcgcttcacc atctgccagt tttgtcacaa 2471161 agtctgatgg tgacggtgta agcgaaacac aaagggttga aaaataggtt tgaatagccg 2471221 aagtcagcca tatgaaagag tcggtgaatg tgactttttc agatttggtt aataaaaaat 2471281 cgagcatatg ataatgaaag gcggataatt gatctttagt ttgttctacc atgtttttat 2471341 cacctaaaag tttaccacta atttttgttt attatatcat aaacggtgaa gcaataatgg 2471401 aggaatggtt gacttcaaaa caaataaatt atataatgac ctttgtgtga aatattgcag 2471461 cctttttgtt cagcttctat gttttcattt tgttccttat caataaggtg tatcgtgtaa 2471521 ctctctgctg ctggagcgag gatacatgaa aacaaaatgt gcatggtcga atagagcaga 2471581 cggtttttat tttccacaaa aataaaacca aaggaggagt cacattatgg ctcgctatac 2471641 aggtccatct tggaaactgt cccgccgtct aggaatctct cttagcggta caggaaaaga 2471701 attagaaaaa cgcccttacg ctccaggtcc acacggccca ggacaacgta aaaaattatc 2471761 agaatacggt ttgcaattgc aagaaaagca aaagcttcgt cacatgtacg gtgtaaacga 2471821 acgtcaattc cgcactttgt ttgacaaagc tggcaaacta gctggtaaac acggtgaaaa 2471881 cttcatgatt cttttagatt ctcgtcttga taacgttgtg tacaagctag gtttagcacg 2471941 tactcgccgt caagctcgcc aattggttaa ccacggtcac attcttgtag acggaagccg 2472001 cgttgacatc ccgtcttacc tagtgaaacc tggtcaaaca atcggtgttc gcgaaaaatc 2472061 aagaaacctt tctatcatca aagaatctgt tgaagtgaac aacttcgttc ctgaatacct 2472121 tactttcgac gctgaaaagc ttgaaggtac tttcactcgt cttcctgagc gttctgaact 2472181 tgctccggaa attaacgaag cgcttatcgt tgagttctac tctcgttaat cgttttaaaa 2472241 acccctgccg ctatgcggtc ggggtttttt tatcggcttt cgcctcttgc tggccaacac 2472301 tatcttgcgc ctgctgctcc caatgatccc gctgcagccg ttcttttgca atcgtacaca 2472361 tgagattcac gctttagcgc tcctttcatt taaaaggtgg tgattggtcg tgtttgccct 2472421 atctaatata ctcttttcct ttcattccta tgcggtaaac aaaaagatcc tttgccttca 2472481 gtggcaaagg atctttttct tatttatacg tcacaaggaa gtattttttc ttcccgcggc 2472541 gcagaacagt aaattggttt tcgatgcggt cttcacctga tagggtataa tttatttccg 2472601 tctggcgttc accgttaatg taaacagctc cgttttggat gtcttcacgc gcttggcgtt 2472661 tagaaggaga taatttagat tgcaccaaca catctacaag tgaaagctct tgggtgctgt 2472721 caacttccat agaaggaaca tctttaaagc ctacttttac gtcttgagca gaaagctctt 2472781 taatattgcc gctgaacagc gcttgggaga tgttgatggc ttgctccagc gcctcgcgtc 2472841 cgtgaacaag tgatgtcact tcttctgcca ggcgtttttg cgcttcacgt ttttctggcg 2472901 ccgtttctgt tttttcagcg tatgcttcaa tttcctcttt tgaaaggaac gtgaagtatt 2472961 tcaagtattt gacaacgtca cggtcgtctg tgttgatcca gaattgatag aattcatatg 2473021 gcgatgtttt ttctttatca agccagatcg cgccgccttc cgtttttccg aacttcgtgc 2473081 cgtctgcttt tgtgacaagc ggaatcgtta ggccaaacgc ttttgctcct tcttcttctg 2473141 attttctgat cagttcaaga cccgctgtga tgttgcccca ctgatcgctt ccgccgattt 2473201 gcagtttaca gtttttgtct ctgtaaagat ttaagaaatc ataagattga agaatcatgt 2473261 agctgaattc cgtgtacgag atgccggatt caattcttga gctgaccgta tcttttgcca 2473321 gcatgtaatt gatgccgaaa tttttaccaa cgtcacgaag gaaatcgatc acattcattt 2473381 tgccgatcca gtcaaagttg ttcgcgatga cagctgggtt ttctgctgct tcaaaatcta 2473441 gaaatctgga cagctggttt ttgatttttt gggaccattc ggatacgatg tcagcagtgt 2473501 ttaatgtacg ctctgctttt tttccgcttg gatcaccgat gaggcccgtc gcgccgccca 2473561 caagcgcaat cggatgatgc cctgcaagct gaaaacggcg aagtgttaaa ataggcagca 2473621 ggtgtccgat atgcaagctg tctgctgtag ggtcaaagcc tgagtacaag cggatttttt 2473681 cttcattcag ctgtttattt aacccttctt catctgtcat ttgctgaatc aatccgcgga 2473741 aggataagtc ttcaagtaag ttagtcataa gataaagctc cttttttaat taaaataaaa 2473801 aacgcccctt cgtttacacg aagggacgat tgattatcgc ggtaccaccc tactaataag 2473861 agaatgcaaa cattcgtctt atcactttgc ctgataacgg atcaggtccg ttctttcact 2473921 actgaaagcc tggccggctt tgtttgcaaa agcggttcat gagtgtattc gatatatccg 2473981 tctgtgctga ttttcaccgg ccatcagctc tctggaacgt aaggatattc tacttgtctc 2474041 aatctttacc ttttcatatg aagctatatc atttttaaca taaataaaat cctgtgtcaa 2474101 cgccgccttt taatcctcca ttgttgacag atctccagcc ggcagattaa gctcccatgc 2474161 cttcagcacg cgcctcatga tctttccgct tctggttttc ggaagcttat ctttaaattc 2474221 gatctcacgc ggagccgcat gggctgcaag accctgcttt acaaataggc ggatctcttc 2474281 tttcagttta tcagacggct caaatccttc cctgagtgca ataaaggctt taatgatttc 2474341 tccacgcacc gggtcaggct ttccgataac gcctgcttct gcaatagccg gatgttcgac 2474401 aagcttgctt tccacttcaa atgggccgac gcgctcaccg gaggtcatga tgacgtcatc 2474461 aactctgcct tggaaccaaa agtatccctc ttcatccatg taagcagaat ccccagacac 2474521 ataccagccg cccggcatga aatacgattc atacttttca gggttattcc aaatggtatg 2474581 catcatggaa ggccagccct ttttgatggc gagattgccc attcggtacg gcggtagctc 2474641 gttgccttga ttgtcaacga tcgctgcctc cactcctgga atcggcttac ccattgaacc 2474701 cggtttaata tccatgcaag gatagttgca gatgagctga ctgcccgttt cggtcatcca 2474761 ccaggtatca tggattcgtt tgttaaaaac tttatgtccc catctgatga cttccggatt 2474821 tagcggctca ccgacactga gcacatgccg gagtgaagtt agatcatatt tcgcagccat 2474881 ttcatctccc gctcccatca gcatccgaaa agctgtcggc gcgctgtacc agacattgac 2474941 gccaagctgt tcaatcgttc cataccagct ttccgggctg aaacgtccgc cgacgatgac 2475001 atttgtcgct ccgttcagcc acggtgcaaa aatgccgtat accgtacctg tcacccagcc 2475061 tggatcagcc gtgcaccaat aaatgtcttc ttcctttaaa tcaaggaccc actttcctgt 2475121 ttgatattgc tgaatcatcg cttcatggac atgcaacacg ccctttggcg taccagtgga 2475181 acctgatgta tagtgaagca gaaagccgtc ttttttatcc atccattcga tatccaatct 2475241 tgtgctttcc tgtttcgctg cttcatcata attgatgata ttcgtgccgc tctcagcctc 2475301 tcccccgact acgaagacat gctgcaagtg aggcagtttg tctaccggta ttctctccag 2475361 cagctcaggc gttgtgacaa caacctttgc ctcactgttt tcaagccggt ctttcaccgc 2475421 tccctccata aatgcttcga acagcggccc ggcgatggcg ccaattttga ttgcgccaag 2475481 cataataaaa taaagctcgg gtgatctcgg cataaaaata aaaacgcggt cccctttttc 2475541 cacatttcca taccgtctca gcacattccc ggctctgttt gattcttcct tcatttcttt 2475601 aaatgtgtat ttttcatccc tttttgcgtc tttataataa agcgctactt tgttttttcg 2475661 aaacgattcg gcatggcggt caatcgcttc atacgccgca ttcagtttcc ctgtctcatg 2475721 ccaagagaaa tgtttctctg cctcggccca atcaaaatgc cggtacgttt cttcatagtt 2475781 ttttaagtta tgatccccct ctattgctgg taacgctttc aagttcatgc ccaaacatcc 2475841 ccctttgctg aagttgtcac aattattata gtatatattc atattcttct caatttttaa 2475901 aatataaacc atgttgaaaa cgctttataa tttggtattc ttaaagaagg catgtatttt 2475961 tgataagaat tgatgggacg gtgaattagt ggaacatcat aaaacatacc attcagcaaa 2476021 catcaaaaca gcaaccggct ctttactgat agaagggcct gtctctccag aggatttggc 2476081 aggttatgag tttcataaag atttaaccgc atttcgcccg cctcgcgagc agcatgaagc 2476141 gctagtcgac attgcaggcc ttcccgaagg gcgcattatt attgccagag acggccgaac 2476201 cattgtcggc tatgtcacgt atttatatcc tgacccgctc gaaagatggt ctgaaggaaa 2476261 tatggaggat ttgattgagc tcggagccat cgaagtagcg ccggactatc ggggatgcgc 2476321 tgtcggaaag acgctcctga ccgtcagcat gatggatgaa caaatggaaa actacattgt 2476381 gatgacgaca gaatattact ggcattggga tttaaaaggg atgaaaaaag atgtgtggga 2476441 atacagaaag atcatggaaa agatgatgaa tgcaggcgga ttggtctggt ttgcaacgga 2476501 tgagccggag atcagctccc accctgcaaa ctgtctgatg gcccgcattg gaaaaaacgt 2476561 cagccaagaa tcaattgagc aatttgacag gctccgtttt tatcatcgtt atatgtatta 2476621 actgacactg acaaagggga aaaaataatg attgttgagc aaatcatgaa aagagatgtc 2476681 attacattaa cgaagacgga tacgcttgaa acagcaatat gcaaactgaa ggaattccat 2476741 atcaggcatc tgcctgttgt agatgaagaa cgacacgtga tcggcatgat tacagacagg 2476801 gacatgaaac aggccagccc gagtattttt gaagaaaaca aacgaagcct atttctcaca 2476861 cgaagcgtag attcaattat gaaaaaggat gttgtctgcg cccacccgtt agattttgtc 2476921 gaagaaatat cagccgtgtt ctacgagcat ggcatcggct gcctaccagt ggtacaccat 2476981 caaaaattaa taggcatttt aacaaaaacc gatttgctgc ggacgtttgt caaattgaca 2477041 ggcgctgacc agccgggctc gcaaattgag ataaaagtaa acgacatcac caaaagcctc 2477101 gctgagatca gcagtctttg ccaagacctt caagtgaaaa tattaagcgt gcttgtttat 2477161 ccgcatgacg atcccggtgt aaaagtgctt gtcttccgtg taaaaacgat gaatccgctg 2477221 ccgtttttgc aggcattaca aagaaatgga caccacgtcg tatggccgtc agagcaaagg 2477281 gatctgctat gagagacagt gtatttatct attctccatc ctaccaaacc tatatgtttc 2477341 atcaggagca tccctttaat cagcagcggg ttctgttaac atatgatttg cttaagacga 2477401 tcaatgcctt tgatgatgga gacattgtca cccccagact cgcttcagaa gaggagcttt 2477461 cccttgtcca cacggacgat tacattcagg ccgtaaagct tgcgggcgcc ggaaagctcc 2477521 ccgctgaaga aggagaaagc tacgggctcg gcactgaaga cacacccgtc tttgccggca 2477581 tgcacgaagc ggcatcactc ttggtcggcg gcactttaac ggccgcagac tgggtcatgt 2477641 caggacaagc cctgcatgcg gcaaaccttg gcggagggct tcatcacggc tttcgcggga 2477701 gagcatcagg attctgcata tacaacgaca gcgctgtggc tattcaatat atccagaaaa 2477761 aatatagcgc cagagtgctt tatattgata cggacgccca ccacggggac ggtgtgcaat 2477821 ttacatttta cgataatcct gacgtatgca cgctgtccat tcatgaaaca ggaaggtatt 2477881 tattccctgg aaccggtcag atccaagaaa aaggaagcgg aaaaggatat ggctattcct 2477941 ttaatattcc gcttgacgct tttacagagg atgattcttt tcttgaggct taccggacag 2478001 cagcttcaga agtcgccgcg tatttcgagc ccgatgtcat tatcagccaa aacggcgccg 2478061 atgcccatta ctacgacccg ctgacgcatt tatcagcaac aatcaatata tacgaagaaa 2478121 tcccccgtct tgcacacact ttggctcatc aatattgcgg agggaaatgg attgcagtcg 2478181 gaggcggcgg atatgatatt tggcgtgtcg tgccccgcgc ctgggccaga atatggcttg 2478241 aaatgaaggg aattgacccg ggtcacgaga tcccgccgga atggattgtt aaatggcaaa 2478301 aacaatgccc cgtggccctt ccgtcgagct ggagcgatcc ggctgattta tatcctccga 2478361 ttccccgcaa gcctgaaatt acagaaaaaa atgcccaaac tgtcagcaaa gcattatatg 2478421 cgatacgttc tgaacagcaa agaacaaagt aaaaaacgac ctttacgaag aggtcgtttt 2478481 tgatttttta atcactattt ccacacgccg attttccttc atgtgttcat ttgtcttgtt 2478541 atcctttact ggctttgtat ccgcataacc gacagcaata aagcgcttgg agggaagctt 2478601 ctctttagac gtgaagtatt gaatcactcc acttgcccgt gctgctgata gctcccagtt 2478661 cgacgggtat cggtatgtcg aaatgtttcg gctgtctgta tgtccctcaa cctgaatgtc 2478721 atttggaatt gtttgaagaa gaacggcaat ttggtgaaga agtgtttcgg catttttcag 2478781 cacctttgcc tcacctgtat caaacagcac agcctcctga agaacgagca cgacaccgcg 2478841 ttcatcccgt ttggctgtca tttgggcctt caaatgattg tcttttatat atgtatttac 2478901 tttcttgaga agctgatcct gctgatcctc ttgcttcttc gtatcagatg gggatgtatt 2478961 ctttttttct atggatgttt ggtccggctg aagcccgttg ccttccttct ggatcgagtc 2479021 cactgccgct ttgaattttt gcagatcgat ttgggacatc gaaaagagta aaataaagaa 2479081 cacaaggatc aaggtgatca gatctgtaaa ggttaccatc cagctggatg aagattgact 2479141 gttttttccg cttccattcc ttctttcaaa acgttctctt ctaagcttca tgtacagatc 2479201 ccttttttgt ttttacttgt tttggctgct tctgccattc ttcccgtgag ctgaaaacga 2479261 ccagctggct ttcaaggttg cgcgggtttt ttccggattg aacaccgata atcccttcca 2479321 ccattacctg cttgatgaaa atttcacttt ctgttttctc ttcaagctta gccgcgatcg 2479381 ggttgaagac catatttgcc agtaatgaac catataaagt cgtcagaagc gcaatggcca 2479441 tgtttggtcc gagcatatgc gggtcgttta agtttttgag catcagcaca agcccgacga 2479501 gtgttccgat cattccccat gccggagcga attctcccgc tttttcaaaa actcgccgcc 2479561 cttttcggtg ccgttcctcc attgctgcga tttctgaatc catgacgagc cgaatcgttt 2479621 cttcatccca gccgtcaatc gctaaaagca gccctttttt caagaatgga tctttgattt 2479681 cccgagcctg atcatccaat gataaaagcc cgtgttttcg cgcgtgatcg gaaagggaaa 2479741 caaaggtttt cacaagatct ttcacattgt cttcctggcg gatgaatgcc tgctttaaca 2479801 cagagggcgc ttttttcagc tcacttggcg gaaaactgat aaaaacagcg gcgcaaagtc 2479861 cccctgttac gatgaagaaa gaggtcagat caagaaaaga gcggaaaccg cttactcccg 2479921 atcctgaaat aatcccgata acaataataa tcgttcctaa cacaaatcca acaggtgtaa 2479981 gataatcaaa acgtttcatc atttctcccc atgaaaaaag caagaattca ccataaaggt 2480041 gaagcttgct ctttgttttt cttatgactt ggttgacttt ctaagctcta tacggtgcgg 2480101 cagttcgacg atatgctctt caaccggctc tttattcatg agcttcgtca gcagtctcat 2480161 cgcaacggcg ccgatatcat atgtcggctg aacaactgtt gaaagctgag gacgaaccat 2480221 gaggcttaat cttgtattat caaaaccgat aatgtcgaga tcctccggaa tggataagcc 2480281 ctgatcctga gcggcatgga taatgccgag tgccatttca tcagttgcag aaagaatggc 2480341 tgtcggtttt ttatccaggc tcatcagatg ctgcagtgct tcgagtccgg aatcatatgt 2480401 gtaatcccct tcagctacaa attgttcatt aaacggaagg ttcgcttctt caagcgcacg 2480461 tttgtagcct tggagttttt tcgaacggtt gatcggttct gccattggtc cggaaacgaa 2480521 cgcgatgtct gtatgtcctt tatcaaccaa aagcttcacg gcatcataaa tcgcctgttc 2480581 gtaatcgata gcgactgacg gtgtttcctc ctgctcttct acagaagcgg caagtacaat 2480641 cggcactgga gaacgcttaa attccgccac atgctcgtcc gtaatgtttc cgcccataaa 2480701 cacgatgccg tccacttgtt tgccgagcat tgtgtttaac aagtgcagct ctttctccat 2480761 gttttggtca gagttgctca aaataatatt gtatttatac attgtcgcga tatcttcaat 2480821 tccgcgcgca agctctgaat agaaaatgct tgagatatcg ggaatgatga cacctacagt 2480881 tgttgttttt ttacttgcca gccctcttgc caccgcgttt ggacggtaac cgagacgttc 2480941 aatggcttcc aagacttttt tcctcgttgt cggttttaca ttcgggttgc cgttcacgac 2481001 acgggaaacg gttgccatgc ttacattagc ttctctcgct acatcgtaga tcgtaatatt 2481061 gctcatccta aaaccactcc ttttactgga tacacttatc cttatctata gcataaacac 2481121 tttatgtaga gaaatgtcat aatgtccgaa tttatgtcgt ttatgatttg taagcgtaag 2481181 tcagtagtgt acattatttt tcattattca tcaaatttaa ttacttctca tgaaattata 2481241 cacgttttta tagatgatga aaacgtatac ttggttttta taactaaata aacgagaaag 2481301 cataaaaaaa ggccgcaggc gcggcctttt ggattgttca attaagcgtt gactttcacc 2481361 attggcttca gttcattcag ccatttttcg aattcaggaa tcgccatttg ctgagcagag 2481421 tcagaaagtg cgactgacgg atcagggtga acctcagcca ttacgccatc agcaccgatc 2481481 gctaaagcgg ctttagctgt cggaagcaag aggtcacggc ggcctgttga atgcgtaaca 2481541 tcaacaaaga ctggcaaatg cgtttcttgt ttcaaaatcg gcacagctga aatatccagc 2481601 gtgtttctcg ttgctgtttc atatgttctg attccgcgct cacaaaggat aatttggtca 2481661 tttccttgtg acatgatgta ttcagcagca ttgatgaatt cagagatcgt tgcagcaaga 2481721 ccgcgcttca gaagcactgg ctttttcacg gcgccggccg ctttcagcaa ttcgaagttt 2481781 tgcatgttgc gcgctccgat ttgaatgaca tcaatgtagt ccagcgcttc ttcgatatga 2481841 gccggagtta cgatttcact gataaccgcc agatcaaatt catccgctac acgttttaaa 2481901 atttgaaggc cttcaacacc aagcccttgg aaatcgtatg ggctcgtacg aggcttaaag 2481961 gctccaccgc gcaaaatttt aatcccttgt tttttcgcag ctgcagcgac ttcagctacc 2482021 tgctcatagc tctctaccgc acatgggccg acaatgaatc tttgctggcc gtctccgatt 2482081 ttttcgcctt tgatatcaac aattgtatct tcaggttttt tcttgcggga gacaagcagc 2482141 gctttgctgt gatcttcttc ctgaagctct aaaccggctt tgaatatctc tttaaaaatg 2482201 tgctggatgg ttgaattttc gaacggcccg tcattgtttt caatgatatt gtttaacatt 2482261 gtgcgttctc tgacagggtc aaatcggttg acaccctgtg cttccttcgc tttaccgatc 2482321 tcttttacaa cattgccgcg ttcgttgatt aattttaaaa tttgtaggtt taattcgtct 2482381 gctttctgcc ttaaaagctc taactctgtg ttgctcattt ttttcatcct ttccctgcac 2482441 attcattttt tattttgtag ttatcatgca tcttactata agtaattcca aatggaaata 2482501 ctgaaataca aaaaatttta taaaaactct actttattac ccaaacgctt ttaagtgata 2482561 aagtaatcta tgaagctatc ctacatgatg tgagggcaat gttcaagggt tttttacaaa 2482621 aaaaagcgcc agatgatatc tggacgcttt tttctatgac aaatgctgct caatagcggc 2482681 ttctgtaatt tgtgaatgtg aggtatgcca tttcacttca ccgttctgga tgatgaatat 2482741 ctgagggctt tcatgcttga ccccatatgt ttctgcaatg aaattggaca gcggccgggc 2482801 ttcttgtact tgaagatagt aagccggcac atcctcatgc tgatttgcaa aggcatcaaa 2482861 ctcatgaaat gctgcctggc tgatcgggca tgtggtgctg tgtttcaaga agacgaaaac 2482921 gccttcctgt tctgcaatcc gtttaaattc ttcctcagat tgaataagct gtttagccat 2482981 gactcaagct cttccttccc tgctcagcga ttcaactgct cagcctgttt ttgtgcatct 2483041 ttcagttcgt cttttacatc ttctttcgtc tggaggactt gatcttttgt ttcatcagct 2483101 gcctgcatcg cttcttccct catatcttgc attgcagtcg atgaatccgt tttgtcagat 2483161 ttggaacggt ctctcaaatc ctttaccttg ttcatgatct gtccagactg atccgctaca 2483221 agctgtgtga tgttggaagt tttgtctttt gcgatgctga catattgcgt gcctttttcc 2483281 ttcgcatctg ccgtcatttt atcagttttg tcccgtaagg caacagcctg gctgccgaga 2483341 tcgtcgcgaa gttctttgcc tgatttaggc gctagaaaaa gagctgtagt ggcaccgatg 2483401 attcccccga ttaaagttcc gattaaaaaa tctttactat taattccatc tttgctcatc 2483461 attattcctc ctcttagtat ttttttctct tacagggctg attttttctt ttgcttccat 2483521 ttctcccaaa tttccattgc tgcttgactc caagtgacaa cttgattgat cttatcttga 2483581 ttctctctaa ctgatgccga tacagaccct gccgcttgtt tcatggatgt attgaactgc 2483641 tgtacagaag ctcccactcc ttgaacagca tgaacgaccg tgttcagctt ttctgatttt 2483701 tcctgaatat cttcagccag gcggttggtc ttatgtaaaa gctcggctgt ttcagttgtg 2483761 atgcccttca tttgtccctc cagcccttca agagtggatg cgacgttttt tagtgtcagc 2483821 tgcagtgact tcaatgtttt agacaagtag atcactaata cgagaaatgc aactgcgatg 2483881 agtgcaacgc tcaaataaag aataataatc atctcaaacc tccttgctgc aggatatact 2483941 gctgtttacc cgttttcttc aatcataaac atgtgtactg ggctgtatac atactattct 2484001 ccgttatgta agaaaatcct ttaataagct ttcccatcag ataaataaaa agcagtgaga 2484061 tcactgcttt ttattatgcc atgacgtttt cgtaggctct catatatttt tggatatctc 2484121 ctgctcccat gaagatgaga acggctttat catgagcttt taaaacagat gtgtcatctt 2484181 cttcaatcag cttggcatta tgaatttttc cctggagatc accgatcgtc agctttccgg 2484241 cattctcacg ggctgagccg aaaatatcgc ataaatacac acagtcggcg ccgctcaggc 2484301 tttctgcaaa ttcgtcaagg aactgctgcg tccgggtaaa tgtatgaggc tggaataccg 2484361 cgacaatttc ccgatcagga tacttctgtc ttgccgcctc gattgtcact tttatttctg 2484421 tcggatgatg ggcatagtca tcaatcagca cttgatcccc aagctgcttc tcattgaatc 2484481 tgcgtttgac gcccccaaag gatttgagag catgcttaat gatgctggaa tcaatttctt 2484541 cataatggca taacgcaatg accgccaatg agtttaatac attgtggtgg ccgtacgcag 2484601 gaatataaaa cgtatcatag aacgtattgc ggacaaagac atcaaaagtt gtcccttccg 2484661 tgctttttac gatgtttctg gcttgaaaat cattttcttc ccccgtgcca taatacacaa 2484721 ccgggacgtt cgcatggatt ttcggcagat gctcatcgtc tccgcaggca ataatgcctt 2484781 tgttgacttg aagagccatc tcttggaaag cgtcaaatac atcgtcaatg cttgagaagt 2484841 aatcagggtg atcaaaatca atattcgtca taatcgcata atctggctga tagcttaaga 2484901 aatggcggcg gtattcgcac gcttcaaaca caaagtattc gctgttttca tttccctggc 2484961 ctgttccgtc tccgattaag aaagacgtcg gttttgcgtt ttggatcacg tgagccagca 2485021 gacccgtagt cgacgttttg ccgtgtgcgc ccgtaacggc aacactcgtg aattttttca 2485081 tgtagtcgcc taaaaactta tgataacgta tcaccggaat tccctcagac atcgcttttt 2485141 ctatttcagg atgcgtgtct gggaatgcgt ttccggcgat gactgtcatg ccgggtttaa 2485201 tattttccgc gctaaaagga agaatcgtaa tatttctttt ttcaagcgct gtttgcgtaa 2485261 aaataaattt ttcgatatcc gatccttgga cagtatatcc attatcatga agtatttggg 2485321 caagcggact cataccggtc ccttttattc caacaaaatg ataaacagtc ataattgtac 2485381 ctccaacaaa cgtctatctg ttccccagta tatgacgctc atttcaattt gcgaccgcgg 2485441 cggctgaaaa gcctccctta gcggcgtatt ttatatgttt tgttatgttt agtatcaggt 2485501 tatttctttc cgattaaacc cagatatcaa gatttgtcta tgcacagctg ctgtaaagcg 2485561 gcatagctgt taaatgctct aaacactatc ataccatgtt tggtgtgaaa atgaacccat 2485621 attattcgtt tattaaatca cttgctgtga tcagcacctc tcgaggcttg cttccttttg 2485681 cctcagagat catgccttcc gcttccatca tgtcgatcag ccttgccgca cgattgtaac 2485741 cgattctgaa tcttctttgc aggcttgaag tgctcgcact gttttgctct acaacaaact 2485801 cacacgcttc gtaaaacagt tcgtcctctt ctttcagggc agatccttgt cttacgagct 2485861 cttcttgttc aaataaatag gtcggcggca tttggcttct gacgtgggaa acgacgcggt 2485921 cgatttcccg gtctgacaca aagttacctt gcagacgaac cggttttccc gagccgtttt 2485981 ccaaaaagag catatcccct tttccgagaa gcttttctgc accggctata tcaataattg 2486041 ttcgggaatc aacctggctt gagacagaaa aggcgattct cgttgggata ttcgccttaa 2486101 tcagacctgt aatgacatcg actgacggac gctgagttgc gacgagaaga tggataccgc 2486161 acgctctggc tttttgggcg atccgcgcaa tgctttcttc cacatcgttt ggagccacca 2486221 tcatcaaatc tgcaagctca tcaataatga caactaaata cggcagcttt tcacccattt 2486281 ggtgttcagc ggttaattga ttaaagcggt caatgtcgcg gacacctgaa tgggcaaaaa 2486341 gctcatagcg gcgctccatt tcctcaacga cccatttcaa agcagccgta gccgctttag 2486401 catcagtaat gaccgggctg acgaggtgag gaattttatt gtaaggggcc agctctacca 2486461 ttttcggatc aatcagcagc acctttacct cactcgggtc agctttataa agcaggctta 2486521 ctaatattgt attgatgcat acgctttttc cggagcctgt agcgccggca atcaagccat 2486581 gcggcatttt cttcaagtcg ataacaacag gatttcccga aatatctaat cccagcgcag 2486641 ctgtgagcgg tgacttgctt gtcctgaaag ctgagctgcg aatcatttgg cgcaaatcaa 2486701 ccaccttgct cgtgcggttc ggcacttcaa ttccgatcgt gtttttcccc ggaatcggcg 2486761 cttcaatccg aatatcttta gctgagagac tgagtttaat atcatcggac aagttggtga 2486821 ttttattcac ctttacaccc ggttcaggat gcacttcaaa tctcgtgaca gacggaccct 2486881 gggttacatg gaccacattg gcgcggacat tgaaattttt caaggtcaaa tcaagaagct 2486941 gacgctgttc ttcgatccac gcagtatcat cttgaacctg cgctggcggg acatcaagca 2487001 gtgcaacatt cggaaataca tagctgccgc ggcgctcctc tgctttttgc tgtttatgcg 2487061 tatctctttt cagcatcatc acattaaaag gaacggatgg ccctttttga gaagatgcgc 2487121 tttgttcagt ccttttctcc tgtacaccag gccttttttt cggctcttct gaagcttcgc 2487181 gaggtttgtc tgcgcgaatt tcctgccggt tttcaagagt tgcagtagac gatttggaac 2487241 cctgctccat gtgttcagtt ttctcaagct ctgtatggct gtctggctga acatctatct 2487301 tcgtttcctg agcctctccc agggtgtcat aatgattatt tattatgctt tctgatggct 2487361 cttctgattc ttttgccaca gtttctgctt gagccagagc ctctgatgaa tactcatgat 2487421 cagtaaataa aggctcttcc tgacgaatgt ccatttgttc ttcttgaacg aacggggact 2487481 cagcaccttc tgccgcgttt tcatgatgat tgtatactgg gctgtctgac ggctcttttg 2487541 ctttttcatc ctcagatact gcctctgtct gagattcagg agctgtttgc tcttcatcaa 2487601 gttcagcgga gaaaacaggc tcttcaaatt tctctggctg ctgctccctt tgttcttcct 2487661 cagccgttgc aggctcttcg cggcctactt cactgtctga aagcccttca gccgccgtat 2487721 ctgtgagcat ctcaggcggt gtttgctctt cggcttgttc agctgggaag aaaggctcct 2487781 ctttttccgg ctgttgaacg cctgactcaa atggcacttt gttacctgac ggctcggctg 2487841 gccgtttcgc cagcgcctca tcatgctccg tatcctttct gtttaaaacg ccagaaggct 2487901 gtttttcaaa ttgggtatcc gggaagaaag gactttctat tttggaatgc gcctgtgtgt 2487961 ctgaagcagg atagccgcgt tcacgttcga tctcttctga cagcagtgtt accttctctt 2488021 ttaccgattt atccggttcg ttcaatgttt cagaaggctt tttcggcaca tcctttttaa 2488081 cagatggttt ttgattgaat ccatagacag gcgaagggat atttgtcggt ttaaacggtt 2488141 tcttcgccgg ctctgctgct tgatatgtat gctgctcttc ttcatttctg ggacgctctc 2488201 tgtaaggtgc agcacttgga cgaggcgcgg atttcggttc gtccgatggt gtgcggcgcc 2488261 ttctcaggtc atgatttttg tatccgtcag gcacgactgg aaaacggaat ttgccttttg 2488321 gatattcata atatatttta ggatcttcca atctttttaa ttgtccttca ggatgatgta 2488381 cttcttgttg ctgcggaatt tgagcgggtt ttgtctcccg ttcagcatcc tcttcgcttt 2488441 cgcctaaaaa caaatcaaaa aatttatgaa gccaactcat aatttatctc taactccctt 2488501 atagttttct gggacggttt ttagtatacc actgctggtc ggcccagaaa agattaagct 2488561 atcagcagaa acaaagccgc taaacaaggg cttagcggct tttcacatga ttcgtttttt 2488621 ttggcggatt tatgggagtc taaaactgaa atgcgtctcc cgcctcatag tctccttcta 2488681 acacaaggat tcctttttca gcaggggcat ccggcaaatc aagctctttc gctgagcaga 2488741 tcatcccgct tgacggaacg ccacgaagct ctgcatcctt aatgacaagt ccgctaggca 2488801 tcacagcacc gactttggca acgacaactt tttggccttg gtcaacgtta ggcgcgccgc 2488861 agacgatctg aagcgtttct tctcctacgt tgactttaca tacgcttaat ttatccgcat 2488921 tcggatgttt ttcttttgat tctacataac ccacaacaaa cttcggagat aaatcaacga 2488981 ctaatgtttc ttcaacgccg tttctgttta aaatctcatt cacatcttgc acgaatgttt 2489041 ctgagagcgc aacagggccg ttttcatcaa tggtcaagta agaagacgca ttgaaaatgt 2489101 tgaagcccgt tgtttctttt gtttcgttat tgaaaatttt gacgacgtcg ccgtgttttt 2489161 catagcctaa ttgttcgcgt gtcacatctt gaagagagat caggagcgtg tctcccacac 2489221 cttctttatt ataaaaagcg ttcataagta aaaatccttt ctaatccttt ttcggacggc 2489281 ttttcgccag gataaacacc ggttccagct ttccttcatt gtacaaaaat gatagggcgg 2489341 taatcgggac ggtgccgcct gcaaagaagc tcatcgacat ttgtcctaga atatcatacc 2489401 ccgattcatt ccggatgtca gcaagaatca aaacgtcctg atgaggaaca gagatcgcca 2489461 gctcaccttc tgcatgctgc ttatactcat ttaagatcgc ttcgttcaaa atccggcttg 2489521 cgtcgtatcc gtcgtttgcc ctgaagaaat aaaagtaatt gccggcaacc gtatcctctt 2489581 tgacaaccgt cggcagggaa cggagattaa atgcggccgt ctctctgatc cgctcttttg 2489641 tccagttttc tttctcaagc atgcgctggt caattaaacg gtaggttttc ccgagatcta 2489701 gcgcgtaata aattcttgtc tctgcggtat gatcgtcata aatgagcggg atatcttcgc 2489761 tggacttgtc cgggaaggaa gtcgagcgga tgaccggata aatgcgagtt tctttcccgg 2489821 tcatttcctg agccttccct tccattgccg tcatcgcttc ggagacatag tacacgatct 2489881 catcaatggc ttcgtctttt ttcagttccc attttgcaat aatcggcggc aaatcgagtg 2489941 taatcccttt tttagtcgtt tgatcctcaa cacggagggt gtctttttct ctgtcaaaca 2490001 gaaaggagcg attctcgtgc tgaaggcgct gcttcagtat atctgacagc ttccttgagg 2490061 tcattttcaa accgatgtcc tcctttacgc tttagcgaga gagtctgtta aaaactgttc 2490121 aatttcttct tttgttttgc ggtctttgct cacaaaacga tttacttctt ttccttcatt 2490181 aaacaccaca aagcttggga ttccgtaaat ttcccactct gcacatgtat caatgaattt 2490241 gtcacggtct acgtagtagt aggtgaattc agggaaattc gcttccagtt caggcaggaa 2490301 aggctctaca aaacggcaat ccgggcacca atcggccgaa aacataaata cagaccaatc 2490361 atcctttacc gctttttcca gctcttgagt tgattcaatt tttttcattt catatccctc 2490421 cagttgttta tgttcttaca tgttttttat cgatactcgt ccatttggat cataccaaac 2490481 tgcttgaggc aaaaccactt atatgcaacg aatgaatatg taagattggc tttcccatta 2490541 tcattatcat attttatttg cattatcaag ctcgtttcgt ttaacatcgt gtacatgagg 2490601 gtgaaattta cagatggata tacataagga gggattttta ttatggagtt tatcgtctat 2490661 ttagcaggag aaatccacag caattggcgc gaggaaatta aagaaaaaac aaaatcactg 2490721 aagctcccga ttacgtttgt tggcccgatg gagaatcatg accgctcaga caatattggt 2490781 gaagaaatta tgggcgtaca gccaaatgcc gttttaaagg atgacaaagc ctctgacatc 2490841 aacaacttca gaaccgccgt cctgatgaat aaagcagact ttgtgatcgc cctgtttggc 2490901 gaaaagtaca aacagtggaa cacggcaatg gatgcatcat atgcgatcgc aaaaggaaaa 2490961 cccctgatta tcatccggcc ggaatcgctc caccatcctt taaaagagct ttccaataaa 2491021 gcgaatatta cggttgaaac cgttaaccaa gccattaagg ccctttccta tctatttgaa 2491081 acagaataag aaaaaagctt gtcgatccgg gcttactgct cgttcaacaa gcttttatga 2491141 aacctacata ttttctttaa tcgcatccac tgtctgctta tcgcaggctg ttacaagttt 2491201 gatgagcatt tctttagcag cagcataatc atcaatatga atgatagtag cgtttgtatg 2491261 aatatagcgg gaacatattc cgataaccgc tgacggcaca ccgctgttcg aaatatgaac 2491321 cttgcctgcg tctgttcccc cgccggatac aaaatattga tatggaatat catgcgtttc 2491381 agccatatca agaacgaatt ccctcattcc gcgatgcatg actgtcgttc tgtcaagaat 2491441 gcgcagcaaa aagccttttc caagctggcc gaattcattt ttgtctccgc tcatatcgtt 2491501 tgccgggctg gcgtcaaggg cgaaaaacaa gtccggttta atcatatgag aagccgtctg 2491561 cgcgcccctt agccctactt cttcctgaac cgttgcaccc gcatagagtg tattcggaag 2491621 ctctttaccg tgtaattcct tcagaagttc aatgcttaag ccgcatccat atctgttatc 2491681 ccatgctttt gataaaattt tcttttcatt cgccatcgtc gtaaacggac aaacaggcac 2491741 gatctgctgt cccggtctaa tgccgatttt gatggcgtct tccttatcat ccgctccaat 2491801 gtcgatcatc atgtttttga tatccatcgg tcggtttcgc tgcgcatctg tcaataaatg 2491861 cggcggtatg cttgaaatca cacccggaac cggcccgtta tctgtttgaa tttcaacccg 2491921 ctgcgcaagc aaaacttggc tccaccagcc tccgagcgtc tggaatctga gcagcccgtt 2491981 gtctgtaatg gatgtcacca tgaagccgac ttcgtccatg tgcccggcta ccataattct 2492041 cggtgcgtcc tctgcgcctc gtctgactcc gaaaacactt cccagtctgt cctgaacgat 2492101 gtcatctgca tatttggcta gctcctgctt cataaaagca cgaacctgat gctcattgcc 2492161 cggcgcgccg ggaagctgcg tcagtgtttg gaaaagcgct ttcgtttctt gattcatgtt 2492221 ttcccctcat ttctatgtag tccttttatt ttattagaaa caatgaagtt ttccaagcac 2492281 tctgacccaa tctgctcgat cagccgcgta ttgcttaaca ggatttggct gtttctgtat 2492341 aatgaaaagt acgatcaacc aggaggtgct ttattttgaa attgcgtcat cttcttttag 2492401 gagcaggact tggaatttgt acggctgtcg ttgtgagaca atatgtgatg aagccttata 2492461 tttcttcaga aaaagcgctt cgaattgtaa aatctgcttt taagcagcgg ggcccgattg 2492521 acggatcatg gatttacacc cagccggagc cctacaatat taacggagaa acggtacagg 2492581 tatacaaaac cggcattaca cgatcagctt tcggagaatt agaacagtat gaagtcatgg 2492641 tggatgcgaa aacgggagaa attgttgatg tcattgatac aatcgcctct taacaccgga 2492701 caagcaaaaa atagaagccg ctgcctatgc agcggctctt ttttattata tcgcgcgaat 2492761 cggtttgtat accggatacc acatcgcatc ctgcactgcc tgtataatgt cttcaggctc 2492821 ttccgtagcg acgccttcct tcattgcggt ttttgcaact tcaacagcaa cggttgccga 2492881 aacagtgcgc aaatcttcaa cttttggaag catcggcgcc ccaggcaccc cgacattgac 2492941 catacctgcg attgcccggg cacatgcttc aaacatgccg tcggtaatta attttgattt 2493001 tgtaacaatc gttccaagac cgagaccagg gaagacaagc gcgttgtttg cctgcccgat 2493061 atgatacgta actccgttat attcaactgg cgggaacggg cttcctgtcg tgatcagcgc 2493121 acggccttct gtccattcga ttaaatcctc cggctttgct tcagaaagag ttgtcggatt 2493181 tgacattggc aaaatcgccg gccgtttcac atgtgacgcc atttctttta caatttcttc 2493241 agtgaaagcg ccggaaaccg tagatgtgcc gatcaggatc gtcggtttcg cctgccgaac 2493301 cacttcaaga agatcaatgc ctccgccgtc tccgttccgc tgataatcct tcacttcatc 2493361 agccgaacgg gcatacggct tttggaaatc aagaagctga tccatatcat ctgttaacag 2493421 cccgttcctg tctatgcacc agaagcgctt gtatgattct tcttcactca gtccctcgcg 2493481 caccaatgct tcccgcagct gttcggcaat tccgattcct gccgttcccg ctccgaatat 2493541 aacaactctg tgatctctca gcggaacttt agacgctttt gcacaggata agactgcggc 2493601 caaagaaaca gcgccagttc cttggatatc atcattgaag gtacacactt tatctttata 2493661 gcgtttcaaa atgcttcgcg cgtttttcgc cccgaaatcc tcccaatgca gcaatgcatt 2493721 cggaaatgtt tctctcgcca gcgcaacgta gtcgtcaata aattggtcat aacgttcccc 2493781 gcgcactctg gaatgctggt tgccgacata aagcgggtcg ttcaagaggc tctcctgatt 2493841 tgtccccgca tctaaaacaa cagccagcac tctgctcgga tcaatgcccg cagccgctgt 2493901 ataaaccgcc agcttgccaa tagaaattgc gattcctccg acgccccagt caccgattcc 2493961 taaaattcct tccgcatcag ttgcaacaat taaatcgatc gtatcgcttt gatctttata 2494021 ctgtttaaaa gcttctttca taccgtccgg gtcatcgatt gacagataga gccctcgtgg 2494081 ttttctgtat tcatggctgt atctctgaat tgccgttccg actgtcggtg tgtagacaat 2494141 cgggagcatt tcccctaaat ggtcatttaa caggcggtaa aacagcgttt cattccgatc 2494201 gtgcagcgcc gttaaataga catttttgct caaatcgtca ggctgtgcgg aatattgttc 2494261 atacgctctt ttcgcctgat catcaattgt taataccttg ggcggcagaa agccttttaa 2494321 accaagttct tttctttctt cctcagtaaa agcaacacct ttgttcaaaa aaggaacaga 2494381 gagcacttca aggcctctta atgttgtttg aatgtctcct tcgtttgtta ctctgaattg 2494441 tttcaccctg cctcttcctt tctgagcata atagtactag gtttgcatta ttagccggaa 2494501 aacatgcagg gtaaacataa aaatatgcta tcgcttcatt cgcttaactg actttttgat 2494561 gcttccgtcc tcctcccatt gaagggcgcg atactcggca tcatggtaaa aaataaacca 2494621 agcatctttt tctgctgcga acgcctgcca tttctgcttt tgcgggatag aggtcatcgg 2494681 ataatcatcg taagccagca cccatagcgg attgcggtgg gcatgtgtcg gcatcagatc 2494741 tgccatatgt acggcagttt cacccgcatc ctcgcatatc aggacactgt gtccgtcgct 2494801 atggcctccg gtgtgatgca ttgtaatacc ctctgtgatc gttaaggtgt cttcaaaggt 2494861 tttgacttgg ccagctacag cctcccaatt ttctttccaa tacgtatttt tcgacctgat 2494921 attcggatgg cgcatttcgt cccattcaac agctgatgta taaatcactg cattcggaaa 2494981 gacagagacg agccgttcac cttcatattc cgttaaaccg catgcatgat caaaatgaag 2495041 gtgtgtcatt gcgatcacat ctatatcggc aaccgttaat ccgagtgcag ctaatgaggg 2495101 tttcacattc gactcttgtg tcacgccata gtttcgtttt tgtttatcag tcagcttgcc 2495161 gtacccaatt ccggcgtcaa tgatgatatt gagcccatcc ttttgaatca aaatagggtc 2495221 tgttcttagt tcaatctggt ttttttcatt gactggatat tttttagacc aaagcggctt 2495281 tggcacaacg ccgaacatgg cgcctccgtc catatgcgtc acgcctccgt caagccaggt 2495341 caacgtgatg tttccaattt tcattgtttc cattttcacc cccccctatc atcatggtag 2495401 caaacggccc ataaaaaaaa cagactcctg tcagagtctg tctttacgtt ctccattcaa 2495461 cctcagcccg atagatcggc tggccgagtg cagagaattt ttcttcatat tctgtcataa 2495521 tattgccttc cagattgctg ttatgcaaat cgagactgac gtatgtcagc aggaggccgt 2495581 actcagagaa gctcttcaaa gagtactcaa ataaacctcg gttgtccgtt ttaaaatgaa 2495641 tcgatccgcc tttgcccatt acttcttcat attttttgag gaagtgggaa tatgtcaggc 2495701 ggcgtttttc atgccgtttc ttcggccaag gatcagaaaa gttcaagtag acccgtttca 2495761 cttcccccgg ctcaaacaca tccgtcagcg tgtccgcatc tatattcaga agctttacat 2495821 tctgcgcttc gctgtctttt actttttgga cggctgtcac gatgacgctt ttaaataact 2495881 caataccaat ataattgatg tcgggatttt gtttggccat accagaaata aattggcctt 2495941 ttcctgtacc aacctcgata tggatcggat tgtcgttgcc aaacactgtg ttccatttcc 2496001 ctttataatc agcaggattg ctgatggcaa tatctgcgtt ttcagccaaa aagtcatcag 2496061 cccaaggctt gtggcgcatt ctcatatgat tgacacctct atctattatt tcgactaaca 2496121 acataccatg aattaaaaag acccgcaagc tcgtttttcc agtgtatctc tcttaaggcc 2496181 gagcgcataa aaaaagaggg tcccgtctgc tggaacactc ctttcccatg tataaaaacg 2496241 ctctgttttg aacaatttaa cccgtatgat actgaaggga tgtgtaccgt tatgggttta 2496301 cattatgagc atcaagttca tttattgaag gatatattga ctgaccatca attggactgc 2496361 tgcggaacag tcgcagagta cgagcagctt gagcgtgtga ttaaatcact gatggcaaac 2496421 accgagcttg attcaaattt caaaaacgtg cttgaagatg tttaccgcta cagccaatca 2496481 ggaatatcgt ccaaatccat cgactcacac atacaagagc atcagaacag cctgtctcaa 2496541 tgggtagagc aaatggattc gtattcctga ttaatcaaca attcgtttca tgaggatatg 2496601 cagctcttcc attgcatcat gaaattcctt atcattgcct tttgctttat gccaggcaat 2496661 gaaagtaatt gtttcagata acacatacca agccattcgc aaccgaaggc tttctgtcag 2496721 ctctatgccg tacatgctca gccagctctc ccaagctggc ttttcgacgt agtggtacag 2496781 caaaggcccg aggtccatcg ccggatcagc gatcatggcg ccgtcccagt caattaaata 2496841 cagctggttg tcttcagaca atagccagtt attatgattg acatcacaat ggcaaacgac 2496901 tttctcaccg aaatgcactt catgcaggtg ttcttccaaa tacttgatcc cttcttgaat 2496961 cagcggcgaa gattgctgca cagcaaatac agcctgcttc agctgagaca aaagagcccc 2497021 cgggttcagc ggttcttttc caagtctctt cagcatgtcc agcaaggctt ttgatgtgtg 2497081 tattttacga agcaattcag caacgggccg tccgctcatg tctttaggct tcagctctct 2497141 gccggtcatc cagtgctggg ccgtaatgac gtccccattt tccatccgtt ttgtccaaac 2497201 cagcttcgga acaatgcctt cggcggataa aacagctaaa aaaggtgagc tattacgttt 2497261 taaaaaaagc tgctgcccgt tatgtttcgc ataatatgca tctcctgtag ctcctccggc 2497321 ggggaagatc tcccaatcgc tacctagtaa ttgtcccaac cagttcatat caatgttcaa 2497381 cccatcattt cttaaaatat tttagaatta aggctaatcg tttctagtct atccagcgaa 2497441 tgcctttttc gtacgaatcg tataaaaata aaaaagacag ctattgagag tctcatatgc 2497501 taatcaatag ccgtccttta aattttagcg ctatagcaca aacttcgtca agcaaaactc 2497561 ttaagatctg atgctaaata taagataacc gttccgatgc cgtttactgc aaccgttttc 2497621 ttgatttctg ttgggtcttc ctgaaatcct gatggatcac ataaaagccg ataaggtatg 2497681 tcgtttggca gcctccactc gacggagtct ggactcgcgt gatggataac aatgatatct 2497741 ttccattcgt caacctcgtc aagatcataa agcctgtatg cgataaggtg ttcttttagc 2497801 gtcaagcatt caagatggcg ctggatgtct gcagcggacc taagacggaa tgcaggatgc 2497861 gcttttctca gcgagatcag cctgcggata tagtgaacat cttctttgaa tgtttcacgg 2497921 cgatcccagt cgagctggtt gatgctgtca ctggattgat agctgttttc cactccctgc 2497981 ttcgtccgga aaaattcctg gccgctgtga ataaacggca ccccttgggc aagcaaaata 2498041 atcgcggctg caagcctttg cctgcttcgc tttcggctgt cattttcttg aggaagcgca 2498101 aagctcattt tatcccaaaa ggtgtgattg tcgtgtgatt cgacataatt gatggactgg 2498161 cttggttccg gaacaatcgg tgctaatgcc ttccatccgg aagacccggc aattccatgc 2498221 atcacagctt gtgctgattc accgttgccg agcgcaaacc ctgttgcctt aaggtgaaag 2498281 gtgttccctt ttacagcgtc acgaaacata tcattaaaaa agccgatgcc cggcattctt 2498341 ggcgcgttcg ccaaagcagc tttctgttca tgcggcagcg gtgtagccag gtcccaccct 2498401 tctccaaaaa gcaggattcc gggctttgcc ttagttgctt tctctttcat ataaagcacg 2498461 gtgtcaatat ctaaaatccc gaggagatca aagcggaagc cgtcaacatt gtattcttca 2498521 agccaataga ccacgcaatc cgcaatgaat tttcttgcca tccttctttc tgatgcaata 2498581 tcattgccaa cgccggtgcc gtttgatggc atcccacatt cgtcgtgccg gaaaaaataa 2498641 ccgggcactg tcttttcaaa gggggaattc tccctcttat acacatggtt aaaaacaaca 2498701 tccagaatga ctcgcagacc gtgctgatgc agggtattga tcatttgttt cagctctgtt 2498761 tttctcgttt gaggatcatg aggatttgag gcatagcttc cctccggggc aaagaaatga 2498821 agcgggttat atccccaatt gtatgcatca agcggcttct cttcatcaac tccggcaaaa 2498881 tcattcaccg gcagaagctc cacatgtgtc acaccaagct cttttacata cgctaatccc 2498941 gaagaactgc catttgcggt ttgtgtatca gtttccgtca gcgctaagta ttttcccttg 2499001 tttatcatgc cgctgttttc atggatggag aagtcgcgaa gatgcgtctc atagatgacg 2499061 gcatccacag ggtgtgagaa tggtttaaga ggagcagtcc atttcatttg atccgggcgc 2499121 aagacgacgc ccttctctcc atttacagtc acagccttgg catactggtc aactgtttcc 2499181 atccattctg aattgttgca gatgcaaaac aaatactcat atccgtgaag gtcacctgtg 2499241 accgtgacgg catagacgcc tttttccaag cgagtcattt ggaatgtgcg cccgctttta 2499301 ttggggtgtg aaagcttgac agcagctgag gttgcagcag gcgcccatac tttaaatacg 2499361 gtatgatccg cggtataaac ggcgcccagc tctccgtcat aataaaattc gtcatcaaac 2499421 gctgccgtcc ggatgaccgc gccaatttgg agatccgttt tgtggccgct ggatgctctg 2499481 acgcaatgga tttttccaaa tgtcacagga tggtcggata cgcagacgta cttgtatttt 2499541 gcttcaaggg agtattcctc cctgacagcc agaggaaaat ctgttatttc tgtctcaagc 2499601 cgaaacggcg gtgtcatgat ttccttttgt tcagcaggaa tcagaacagt aatgatattc 2499661 atgtcatcga catacgcttc gaagctgcgg cggatgctga ccatcggaag ctctctcctc 2499721 caaacacgtt tatgttttga ttcttagggg tgaaggacta gatgccagac gaaacggggt 2499781 agtgcccatg atttctccgt cagcatggaa cgggattttg tccttcgtgt aaaatgtaat 2499841 gtccttcgct ttaaacatcg taacgccatc catctttgta tgttttccaa atgccatgag 2499901 acataaaagc caatattttt tcaaaaacgg ctggttttca acgattacga tatcaaatgt 2499961 cttctcgcgc ggatttgcta ggggcgccgc cttcatgcct cccccgtaaa acggatggtt 2500021 ggatacaacg gcaaaccaga catcatgaaa ttcgcgcgtc tcgtcttccg tcgtacaagc 2500081 taatgtaaac ggcttaaagg ttgccgaagc gtgcaaatga gaaagcggat acacaagaaa 2500141 tcgaaggcgg agaaaaagaa aaacccgtct caacggaaat tccatcgcct ttttattgac 2500201 atatgcgtca aacccgatcc cgatatgatt cataaaataa agaatctgtg atttatcctg 2500261 aaggaaattg acgctcccta aatgaaaggt tcttgttaac gggcgcttta ccttcttgat 2500321 ttcctgtatc agatcgattt ttttaataga gaaccctcgc gaaaaatcat tatacgcgcc 2500381 cgccggcaca aagctcagct caatatcgtc aacatctttc agcccgttga caacttcatg 2500441 catggttccg tctccgccaa tgacgatcag gcgcttcagc ttatattcct gtatcgttga 2500501 aatctgtctg gcgagcacct cggcgtgtcc cggatgttca gttaaaaatg aacggtgctc 2500561 aacctttcgt ttgatcaatt ctttttgaat ggacttccaa acacgcaggc cgtttcgatg 2500621 tcctgctgtc ggattaataa taaaaaacca atggctcatc tttctcacct gcttatgtta 2500681 tgagaaaacc gctcaaatcg ttctctttta ctccagccac tcctgtctgc gataggagtc 2500741 agacatgcag taagacaata gagcctttgc agcctttacc tgatgatgtt tgatcggagc 2500801 agtgtttttc ttctgccgct caatccattc ttccgcgctc cgcttatccg ctatttctaa 2500861 gccgtatggc ggctccgggt aatcgatgta cgacgttctg ctcagaagca attttcgaac 2500921 cggaatctca gcctgttttt cctttacgat ctttgacaca accgagtccg tacgaaacag 2500981 gctaagccct ggatttaaca ctgatgcagt ctgagaggct gttttcttgt cccaaaaacg 2501041 atttttagac cctatgtaga cactgtcttc ctcagcctct aaaaaagaaa cgcaataaat 2501101 ttccagagga gaaataatca caatgcttaa ttcaaccgcc gcctgctgaa ttttcagcac 2501161 aggcttatac ataataaaat aagaatcagg cagctgctgg gtcagataac gcaaaatgcg 2501221 gtcctgcttc acttggtttg agagttgaga tatttctgaa agagtagagc ttgcccattt 2501281 gagctgaaaa tcatataaat gccttttata aaaagaagca agcgccaccc tgctcttcgg 2501341 gagccttaca tgaatatctt cttcgtcctc aaaccattgg tgtctctctt cttgtatatc 2501401 ggcttttatc tcttcttttc ttcttttcaa tgaaaatttt tttcgtttct gcaccggttc 2501461 cggttcttca gcactggctt gcctttcttc atgctggcgc tccgctgctt ctactagtga 2501521 aagccagcgc tcttttttca aacgtacaaa ctggttgata taatggtacg gatcaagctc 2501581 atatctcgat atataatcat gaattttgat gatttgtgcc atgtttgttt ctccactccg 2501641 caatgaatta agataattga aatttgaata tttcctcgta ttttggtgat tggttcaagt 2501701 gtatttgaaa gagcgaaaat cgttcagcca tcatcgaaac ctcgccgctt tcaaacggaa 2501761 catgagctgg aaatccatct tcgcctgtcc attttcttgc cagcgtcata tgaggatgat 2501821 acggtctttt ttccacttga aagccggcct gaagtacagc ctgcttcgta tgttcccgca 2501881 gtctatcaag cgttttgttt ttctttggct ccagatgtaa aacgcgcggc tttctgcggt 2501941 cgccgaatac atctatcttg ccaaacttaa ttgaaaatgg atcaatttct gaagcaatct 2502001 ctgctagcga accttcaagc ttctttattt gtgtctcatc cgccgctccg agaaaaatta 2502061 acgtgatatg atagtcaagc gggtgcaccc atttttgaaa cgtcaatatc ggttcgtttt 2502121 tcgcagcctg gtagatcgga tttgcaattc cctcaggtat gggaacgccg atgaaataat 2502181 gaggccgtat atctggcatc cgtctgacac tcccttcttt gacagctatt attttatcaa 2502241 taaagaggct gtgcggatag aggaacagtg tatgaaaaca ctctcgcaca aacgtttatt 2502301 atgttaggat attatatgac acttgtttta ttcagaaagg aatgacaatg ttgaaaatcg 2502361 ttgcaaacac agctgatctg ataggagata caccgctagt gagattgaat cggcttcagc 2502421 cggaaaatgc ggcacaagtc tatttaaagc ttgaattttt caatccgagc ggcagtgtga 2502481 aagacagagc cgcttatcaa atgatcatag aagctgaaca aaacggttta ctcaagccgg 2502541 gatcagttat tatagagccg acaagcggaa ataccggcat cgggctcgcc atgaatgcgg 2502601 cagcacgcgg atataaagca atcttagtta tgcctgatac gatgacgaag gaacggatca 2502661 acctacttaa agcttacggt gcagaggttg tattaactcc cggagaggaa agaatgccgg 2502721 gcagcatcaa aaaagcgaag gagcttgccg aacaaattcc gaacagctat attccaatgc 2502781 agttcgataa cactgctaat cctgatgcgc accgaaaaac aacagcgcct gaaatcgccc 2502841 gggcaataga ggaaatcgga aaaccgctcg gcgcttttgt agcctcctct ggaacgggcg 2502901 gaaccattac cggaacaggt gaggcgctca aagagctttt tccggatatc acggttcatg 2502961 ttgttgagcc agcgggttcg cctgtattat ccggcggaaa acctggcgcg cataaacttg 2503021 taggaacgag cccaggcttt ataccgccga ttttaaatga agacgtttat gatgaaatta 2503081 tcaaaatctc tgatgaagac gcgtatacga cgacaagacg gcttgctgct gaagaaggaa 2503141 ttcttgtcgg tccttcatca ggcgctgcct gcttcgcggc aatcgaaaca gcgaaacgcc 2503201 tctctcctga caaagttgtg gtctgcatga cagctgatac aggagaacgg tacttatcaa 2503261 ctgatttatg gtcatttatt taaaaaaagg actggcttca gcagaagccg gtccttttat 2503321 tttgcaagct cgtaaatggc ctgagcatat aacgctgtcg atctcagcag gtcatcaatt 2503381 tcgatatatt catccttttg gtgtgcgctg tcagggcgtc cggggaacag cgggccgaac 2503441 gcgacaccgg cttttaagga tctcgcataa gtccccccgc cgattgagat taaatcagct 2503501 tttttaccca gctggccttc ataaaccttt tgcagggttt tgactaacgg atgatctgcg 2503561 gacacgtgat gcggcttgct gtctttgaat tctcccagct caaattcaga tgcgctttcg 2503621 aatgtatcgc ggatcacttt gctttctgct gtcacaggat agcggatatt gatcccgagc 2503681 tcgcctcctt gcccttcttt atagcgcagt gttccgacat ttaatgtcag ctctccgctg 2503741 atttcatcct cacagtcgat gtccagtttt tttcctcttg tatcacctga gaacttatct 2503801 gtcacaactt gcacaaaccg ctttcctgca tcgtcaagct cagtctgctg gagaaattcg 2503861 cacaataaaa tgccggcatt gatcccattg ttcggttcca tcgcatggca ggaaagaccg 2503921 tacatacgca aaatgagctg tccgttctct attgcagctt cccctttttg gtccgtcgtg 2503981 cggagcatgt ctttaaatga agacagaatc tcttcatttt tcggcccttc aatgacagct 2504041 tccgcagcgt cgggcaccat gtttaagcga aggcctgatt gaaacgagac aagcactgcc 2504101 tttggttcag cttgatttgg gcggtgcgga ataagtaaag aagcatcgat gatccctttt 2504161 tccgcattaa tgatcggaaa atcggcgtca ggcgcaaagc ccattgttgg catttcttca 2504221 tgcttgaaat aatgctctac gcatctccaa tcactttctt catctgttcc gataatcatt 2504281 ctgactcgct tggacagggg caaattcatg tctttcacga ttttcagcgc gtagaatgcc 2504341 gccattgtcg ggcctttgtc atcaatggcg ccccttgcat aaatccgtcc gttgcggatt 2504401 tcagctgaaa atggatcact cgtccaccca tctcccggcg gcacgacgtc aacatggcaa 2504461 agtacgccga taatgtcatc gccctccccc cattcaatat gacctgcgaa gccgtcaaga 2504521 ttttttgttg taaagccttc tttttctcca agctccagca atgaagtcag gctggcattt 2504581 accccttctc caaacggttt accgggtccg gcggttgttt cgtccatgac actgttgatt 2504641 ctcaaaaatt cctgtgtatc acgaattaaa tcctcttttt ttctgatcac ttcaacttcc 2504701 cagttcataa tgatcccctt tccgcaagaa atgacttgca aaaaccaaat aaaacgaata 2504761 atattaatgg tgttttgtta aaacgttcgt aattggagga tactatgttt catctaaaag 2504821 agcagcaaac atccataaag caagaaatca tagcagggct gacgaccttt ttcacaatgg 2504881 tctatatcgt cgtggtcaat ccggtcattc tggctaacgc cggggttcct ttcgaccagg 2504941 ttttcaccgc aacgattatt gcctccattg tcggaacgct gtggatggcc ctggcagcaa 2505001 attatccgat tgctattgcg cccggcatgg gcttgaacgc ttatttagcc tttcatgtcg 2505061 taagcgcaag cgatggcggc atcacgtacg caacagcttt cagcgcagta tttacagcag 2505121 gggttctctt cattattcta tcgttaacgc ctttaagaaa acaacttata gaagcgattc 2505181 caaacaattt aaaatacggg atcacaacag ggatcgggct gtttattgct tttatcggtt 2505241 tgcgtcaagc gggaattgtg gcagctgatg agtcaaacct ggtcactctc ggcaatctgc 2505301 attcacctgg tgttatctta acgctggtcg gccttttgat cagcgtggtc ctgatggtgc 2505361 tgaatgtaag cggcgcttta tttatcggaa tggcagctac cgctttgatc gcctttttca 2505421 ccggtcagct ccatttttca aagggattta tgtcgcttcc tcatttgccg gaaggattga 2505481 tgatctcaaa tccatttacc gcttttggcg atgtcattca tcacggcctg tacgctgtcg 2505541 tcttttcttt tctattagtc accatttttg atacgacagg cacgatgatc ggagttgccg 2505601 agcaagccgg gctgatgaaa aacaacaagc tgccgaacgt gcgaaaagcg ctgcttgctg 2505661 attcaaccgc gacgacagta ggagctgttt tcggcacaag tccgacgact gcatttatcg 2505721 agtcttccgc cggtgtcgca gccgggggaa gaacggggct tacggctttg actgtcgcgg 2505781 tgatgtttgc ggcttcaatg tttttcagtc cgcttgtcag cgccttgtca ggtatagccg 2505841 ccatcacctc gcctgctttg attatcgtcg gcagcctgat gatgggctca gtttccaata 2505901 tgaactggaa agagatggac gaggcatttc ctgcgtttct cgtcattcta gccatgcctt 2505961 tgacctcgag catttctaca ggaatcgcgc ttggctttat ttcgtaccca attgtaaaag 2506021 cggcgcgggg aaaatggaga gagattcatc cgctcgtcat cgttttcgcc attctgtttt 2506081 tcatccagct gtttatttta taaggataga ccaaaaaacc caaacgtcgc cgtttgggtt 2506141 ttttatgtaa acaataaaga gacagcggcc gctaaaaaac aacaggcggc aaacgcatag 2506201 tgcaggatgt tgatacagct ttttctggcc cgataatatt catcactttc cttatcggtg 2506261 ccaattaaaa aaggggcatc catgaccttg tcaaaaataa gcgtcaggat ataacggcaa 2506321 acccctgtgt ataccagcag cgcaatcacc ttcagccaaa ttggggaaac aaatatgaga 2506381 acagtgaaag ctgacagtag catgtacatc tgccttgcat actcgccatt cctcagcata 2506441 actttaaaaa acaactcctt atagcctgtg cagatcgttc gtcttttaaa tatccttttt 2506501 gaatttcggt ataataatgg ttttcttctc atcctgtctt ttacttttgg cattcccgcc 2506561 tcctgactca tcatcatcac aagtcctgca agggcaagcc tgcttttttt ctcttcagtc 2506621 acctcagctt caaaagccgt gaacgaggct gtctttttca aactgcggat aactgagaaa 2506681 aacaaaaata aaatgccaaa aagcgcaagc aagtgccgct cagtaaaaac aatcaggata 2506741 gcagaaccag caaaaagaat agctctgaca agggtatcgc caatccatct cgaaatggag 2506801 cgcggctttc tgatcctgtc ttgctttaag gataaaaaga atatatgaag gccaaacaaa 2506861 taacacaata gagcagtgct ttctgcgaat gtgatgagaa cagaatgact gatcaaggga 2506921 aggacaatga aaaagagaag cagccattta gccagcgtgg ccagaaaaga atacaaaagc 2506981 gcataccgtt tgagctgata gatgatttcc ttcttttgca gcaaaaacac tttgtccgct 2507041 tccattaaaa atgtacgaat cgaacctgta aacatgatca gcacacacac agcatacagc 2507101 catctccatt ccgccacttc agaccactca taaagaaggc ctcttccgtt catcaaatca 2507161 atatactgat agatgacaaa agcaatcgcc ggcaaaacga tatagagagc gactgtccag 2507221 tcaatgaccg catgcaacac tttaaactga tacttataat agtcaaacag ccttcgaaaa 2507281 aagagcgtac gcccgttcat agccgatcac cttgaactgc cttataaaaa cagtcaagca 2507341 atgactgccc ctctaatccg gtcttgtcct gaacatcttt taacgtgcct tggagaaata 2507401 atgaaccttt ctcaatcata taaaaccggt cacagatttt ttccgcggta tcgagtacat 2507461 gcgtgcacat aagaattccg gctccacgtt ctttttcagc cttaagcatg tccacaaagc 2507521 gtttcgtcga tatcggatca aggccgataa acggttcatc aatcacatac atatccggct 2507581 tagagagaaa ggcctggata agcattagtt tttgctgcat gcccttcgaa aaggtgacag 2507641 gcagctcatg tttgacatga tctagcgaaa acgtctgcag caggctttgg gcccgatgcg 2507701 caaattcact ctcttcaatg ccgtgaagtg tgctgatcag atccaaatgc tcccacagcg 2507761 tcagttcttc gtagaaggac ggatgctccg gaatatatgc aaatgaacag tcgttccagg 2507821 caatatgccc tttaaaatct tctgaaaggc cgagtatcgc cttgattgcg gtgctttttc 2507881 ctgcgccgtt agctccgatc agtccaacca gttccccttt tctgacttcc agaaaaacat 2507941 cggtgagcac tttttttcgg cttgtatacc cggcctgttc tattgaagct tcaagcaaat 2508001 ttgtcaaaac tcactcacct ccaaaattta ctacgaaata gaataaaaaa agtttcttta 2508061 accataataa tattgagccg aaatacatag taatccaaca aggatggctg cccaacgcga 2508121 aattggaaaa aattaatagg agttatccct agattcatca ctgcaatatc gtgtataatg 2508181 agggcgaatt attttaacaa ttacagatgt ctgcctttgt tgctatttcg tacgcagttg 2508241 atagtcgtga gttgtggtta gtcaagtcca tccgatctta tgatagggag tggttttttg 2508301 aaaccttcaa caaaccgtat gctaactcga atcaaatcag tttacatgtt tattcaagaa 2508361 aaaggtcttg tgacaacaca ggaactggtt gacgaattcg gcattacacc tagaacgatt 2508421 caaagagact taaatgtgtt ggcatataat gatcttgttc atagtccaag ccgtggcaag 2508481 tgggagacaa cgagaaagaa agtaaagatt acctcataaa ttgaaaatta catagggccg 2508541 cctgagagcg gtccgataga taacagggcg aagaaactac tgagccttgt ttttgtgtgc 2508601 ttataaataa aaccccgcat tcggtatgcg gggtttttgt catgcttgcg gctcatttag 2508661 caaatgaagc tcttcctctg tcagctcacg gtattctccg ggtgccagag cgggatctag 2508721 ggaaacgcgt cccatcgaaa gccgcttcag ataaaccact tcattgccga ctgcctttgc 2508781 catttgcttg acctgatggt attttccttc tgtaattgtc agatatataa cggtattgcc 2508841 actgtcgttt gttttgattt ccgcttttgc cggctttgtt ttatagccgc cctctatgta 2508901 gacacccgtt tccaaatcgg aaatgtcttc ccgagaaatc tgtgatttta aatggacttc 2508961 atacgttttt ggaacatgct ttttaggaga aaggagccga tgtgcgagct ggccgtcatt 2509021 tgtgagcagc aaaaagccct ctgtatcttt atcaagcctg ccggctggaa atggctcaaa 2509081 tctcatctcc tccggcgtca gcagatcgac cactgtttgc tgccggctgt cctcagtcgc 2509141 cgacagcacg ccctgcggtt tattcatcat aagataaatg aactctcgat aatcaaccgg 2509201 ttccccgtat acggtcacct cctgcgtatc aggatcaacg tgctccttta catctttggc 2509261 aggtttgccg tcgatcatca cggctccagc cttcacaacg gctttgactt cttttctgga 2509321 accatacccg ctgttggcaa gcagcttatc aagtctcatt cccaatctct cctttataaa 2509381 agaaagcccg cagcatgcga gccctcagtt tcatcatatc tagttcatca gcctgcatgt 2509441 ctgcctttcc taaagaaacc tggcaaacgg cggcctaaaa ttttctgcaa aaatcctaat 2509501 cggtagccgc aatacaggta gacagctccg ccaacagcgg ccgcgatcac cacaacaatc 2509561 gcagcttgca tctggccatc ctgataggaa ataaagaagc ctaataccca ctgcacgatt 2509621 ttcacggcaa tacccataat ggctgataag accagcatca aaacagttcg tttaacaagt 2509681 atcttatacg aatagcctgc atggcgctta atcatgataa acccatataa aagggaagcg 2509741 atatatccaa gcgccgtcgc taaaatcgct ccgtcagcct gcatcagctt gatcagcgga 2509801 acattcagca caagcttgat cacgacaccg atcacaaggc tgacaaccgc aaatttttgc 2509861 ttattgatgc cctgcagaat agctgcgttg actgtaaaca aagagaacag aattgcgaca 2509921 ggcgaatacc aaagcaaaat gtttgccccc agttcaggat gaaggctctc tgacccgtaa 2509981 aagaacgtat acgtcggtcc tgacaataga gagatcccga caacagccgg aataattaaa 2510041 aacaggatcg tctgcatcgt ttgattaatc tgctgattta acagcttata gtttccgctt 2510101 gtaaacgatt cagtaatcgt tggaattaat gtcagtccaa aagcagttgc tagggaaacc 2510161 gggatcatca cgagcttctg aacatacagg gttagaatcg caagcatgtc ctggctgatg 2510221 gcttgatgac cggcttcaat catcgctttg ttaaacgtat ttgtatcaat atagttatac 2510281 aaagggatgg ctagtccgac aaaaacgtac ggagcagcat agctgaacag ctcgaaaaac 2510341 attttcttgt agcttaggtt tgctgtcgga cccgtattcg gcatcatcgc cagcaggctg 2510401 cccttccgtt tgttccaata aatataaagc acgaccagcc ctccgaaggc accgatcagc 2510461 gctgcgaagg ttgcatagcc cacagcgatg acaaggccgc cgttgaaaac cttcaaaatc 2510521 aagaatgtcg cactcaatag aaagatgatg cggacaatct gttcaacgac ttgggaaaca 2510581 gctgtcggac ccatcatttg gtgcccttga aagaatccgc ggacaaggct cataatcggt 2510641 acgaccaaaa gcgctaagct gaccatgcgg atgacataaa cgacatgatc aattgtcagg 2510701 ccgttattat ccttgcctcc cagcgatatt tccgcaaaca tcggagccga tagatacaga 2510761 atgaaaaagg ctatcattcc tgtgactagc ataaccgaca tgcccgcctt gagcattttc 2510821 ctgcttgtct cataatcccc ttttgaatta tatttggaaa caaatttaga aacagcggcc 2510881 ggaaagccca tcgtagcaat attcaaaaat aaagtgtatt ggttgtatcc gtattgaaat 2510941 aatgcaccgc ctgtcgcccc gaccataatg ctgaagggaa ttaaatagac catccccaga 2511001 atccgcgata tatatgtacc gagcgttaat acaaacgtgc ctcttaacag tttgcttgac 2511061 atgtttcttc atcaccattt tctacgaaga ttcaactttt ctattttacc acaactgggc 2511121 atttagacgg taataaatac aaaagcaatc ctgtgaacat tcatgtccgc ggcaaaagac 2511181 gtttaaggag cggctttctt tcgctataat agtactgcgg acgggtgtcc gcacacgaaa 2511241 tgaaaagaaa gttgatgata aagatgaaac aatatgacgt aatcgtaatc ggcggaggcc 2511301 cttcaggctt gatggctgcg attgcagcag gagaacaggg cgctggcgtg ttgctgatag 2511361 ataaaggaaa taaattagga cggaaactcg cgatttccgg gggcggccgc tgcaatgtga 2511421 cgaaccgcct tcctgtggaa gaaattatca agcacatccc cggcaacggg cgttttttat 2511481 acagcgcgtt ttctgaattt aataatgagg acattatcaa gttttttgaa aacctcggca 2511541 ttcaattgaa ggaagaggat cacggccgga tgtttcctgt gaccgacaaa gcccaaagtg 2511601 tcgttgacgc gctgttaaac aggctaaagc agctccgcgt aacaatcaga acgaacgaga 2511661 aaattaaatc tgttttatat gaagatggac aggcagcagg gattgtgacg aataatggcg 2511721 aaatgatcca tagccaggca gtcattattg ctgtcggcgg taaaagcgtg cctcataccg 2511781 gaagcacggg agacggctat gaatgggctg aagccgcggg ccataccata acagagctgt 2511841 ttccgacaga ggttcccgtc acttctggcg aaccgttcat taagcaaaaa acacttcagg 2511901 gcttatcact aagagatgta gccgtcagtg tgttaaataa aaaaggcaaa ccgattatca 2511961 cacataaaat ggacatgctg tttacccatt tcggcctctc aggacctgcc attctcagat 2512021 gcagccaatt tgtcgtaaaa gagctgaaaa aacagcctca agtgccgatc agaatcgact 2512081 tgtatccgga tatcaatgaa gaaacgcttt tccaaaagat gtataaagaa ctgaaggaag 2512141 caccgaaaaa aaccattaaa aacgtgctga agccttggat gcaggagcgc tatctcctat 2512201 tcctgctcga aaaaaacggc atctctccga acgtatcgtt ttctgagctg ccgaaggatc 2512261 ctttcagaca atttgtaagg gactgcaagc agtttactgt cctcgcaaat ggcacactgt 2512321 cgcttgataa ggcatttgtc acgggaggcg gggtatctgt aaaagaaatt gacccgaaaa 2512381 agatggcttc taaaaaaatg gaggggcttt atttttgcgg tgaaattctg gatatccacg 2512441 gctacacagg cggatacaat attacctccg cccttgtcac aggcaggctt gcagggctaa 2512501 atgccgggca atacgcccgt tcttaatcat tactctttaa atctcttgcc gccaaactca 2512561 catttgaaca ttccccgcat tcatgttagg gtgagacttg ttttgtttca cctgattgcg 2512621 gggtaatttt aagagaggaa tgagctgcca tcgtacgacc atactaagcc tgcgagcaag 2512681 atataggcgt acacaaaaaa ttagagggtg agaaatgttg aaacatatat ctagtgtatt 2512741 ttggattgtg attgcaatca cagctgcagc tgtattatgg ggtgttattt ctcctgacag 2512801 cctgcaaaat gtgtctcaat cggcacaagc atttattacc gattcatttg gttggtatta 2512861 tcttttagtt gtctctttgt ttgtcgggtt ttgtctcttt ttgattttca gcccgatcgg 2512921 aaaaatcaaa ctcggaaagc ctgatgaaaa accggaattc gggttattat catggtttgc 2512981 catgctgttc agcgcaggca tgggaatcgg cttagtattc tacggtgcgg ctgaaccgat 2513041 cagccattac gcaattagct ctccatcagg tgaaacagaa accccccaag ccttcagaga 2513101 tgcactccgc tatacgtttt tccactgggg tttgcacgct tgggccattt atgccattgt 2513161 ggcattatgc attgcctatt tccaattccg caaaggcgca cccgggttaa tcagcagcac 2513221 actgtcaccg attctcgggg ataaagtaaa cggaccgatc ggaaaggcca ttgactgtat 2513281 tgcagttttc gccactgttg tcggggtgtc aacaagtctt ggtcttggcg caacccaaat 2513341 taacggcggt ttgaattacc tgttcggcat tccgaatgcg tttatcgtcc aattggtttt 2513401 aatcattatt gtgacagtgc tctttttact ttctgcgtgg agcggactcg gaaaaggaat 2513461 taagtattta agcaacacaa acatggtatt ggccggattg ttaatgttgt ttatgctcgt 2513521 tgtcgggcct acagtgctga taatgaactc atttacagat tctatcggac aatacattca 2513581 aaatatcgtt caaatgagct tcagactgac accgaacgat cctgaaaaac gcgaatggat 2513641 taacagctgg acgattttct attgggcatg gtggatttcc tggtctccat ttgtcggcat 2513701 tttcatcgcc cgtgtatcca gaggccggac gatccgcgaa tttttaatcg gcgtcttggt 2513761 gacaccttgt attttgacat ttctatggtt ctccattttc ggcgtatcag ccatggatct 2513821 ccagcaaaaa ggcgcgttca atgtagcaaa gctgtccact gaaacgatgc tgttcggaac 2513881 acttgatcac tatccgctga caatggtgac atcgatcctt gcattgattc tgatcgcagt 2513941 attctttatc acgtcagctg attcagctac attcgtgctg ggcatgcaga cgtcgtacgg 2514001 ttctttaaat ccggcgaatt ctgtgaaact cagctggggt atcattcagt ccgccatggc 2514061 ggctgtgctc ctatattccg gagggcttgc cgctttgcag aacacagcga ttctggcagc 2514121 gctgccgttt tctatcgtta tcctgctgat gattgcctct ctctatcaat cgctctcaaa 2514181 agaaagaaga gagatcaaaa aagcggagaa actcgataaa ccaagaagtc caagagtgaa 2514241 aaaagcatat taacaaaaaa gatctttccg cgcctgcgga aagatctttt tatttgcgat 2514301 ataaaataag ggcggaaaaa cagtaaagct gctcgccgtc tgggtcgcac gccgccgaaa 2514361 ccgtatattt gatatctatc agctgctcct ccgatatccc ttttaaaaat gaattgattt 2514421 ccgtttgtaa gtctttttca tgctcttcat caaataccgc taccttcagc attttatccg 2514481 ctctcctttc tctatcaatc tattccgttt ggaacagcgt tatgatagag aaatgatgat 2514541 tatctcgttt ccggataaaa agctttccgt atatgggatt tcctctgtgg ctcgccgccg 2514601 tgctgctcca ctttcagcag cacggcataa acaatgcgca tatggcagta gctgataagg 2514661 ctgacgctga aaaaagggac aatgcccggc aggtacgcaa gcaagaaaaa gagagcaaca 2514721 gtcagcgcaa gcatagtaag cgtatattgc aaatacgcca cactgagcaa gagcgaaaat 2514781 ttcacataca gacgtttttt ccagtcaaaa tggacaagca gcggaaacac ataaaaaagc 2514841 atggatacga acaaaaagcc aaatatcata atggcgaagc gcaggatgtg cagaaggaaa 2514901 tgacttggat aaattaaggc caaatcaata taaatgatca ctccgatgag cgccagtaca 2514961 gcgccgagca gatttgaacg aaaaaattca cccttgtatt cctgccaaaa cgttttgagc 2515021 accggaacgt tgtcctgccc ctggatccac ttccgcatga cagcgaataa agccgcggtc 2515081 gcgggcatga tgccaaacac gccgagaccg agcaacgtaa aaaacagcca cagcaagttt 2515141 gtatacgcaa atctcataat ccattcgcaa aaacgcagca tccgtcccag tgagccatca 2515201 tgttccatgg cgccccctcc ttttttgcat tatacattct gcatctgaaa aagctctttc 2515261 atgccgatcg gcttcttttc ggcaaccgag cgccacattc cctcaccaac cgcgatggag 2515321 taggctccag cttcagcccc ggctaaaata tcatagcggc gcagcgggtc tttccctaaa 2515381 aaaagatcct caagcaaaag cggatcacct ccgccatgcc ccccttcatt tttgaccact 2515441 tgtatcgtct gctttgattc aaaaagcgga tagtattcga ttgtctgctc aggaaaagca 2515501 aacggaattc tggaaggttc gtgaaattca tttgattcaa tacgtccttt tgtgccgttg 2515561 atcgtcagcc ggtagccttc atacggggcc gaaaaaataa tcgagtagct taacagtgcg 2515621 ccgccatcat atttgactgc cgccacgtac gtatcctcga tgtcaatttc ctcgtcaaaa 2515681 atacacgcgt caggcctgta tgcagtatat aagctggact ggtctcctgc ttcaagatga 2515741 tcatccttta tagaagcttt agaggaacgg ggatgccacc ttgaatagta gtggcatttt 2515801 tctttaacac ggcacgtccc gcaaaaacgc ccgtcttctt ccggcaaggg gttccactca 2515861 ctgtccggcc catagtaatt caaggcgcca taagcaaata cctcttccgg attttgcccg 2515921 agccaccaat tgacgagatc gaagtgatgt gttgatttat ggacagaaag accgccggaa 2515981 aactgtctcg acctgttcca gcgtttaaaa tagctggcgc catgatacgt atcaatatac 2516041 caatttaaat caacagaagt gaccctgcct atttttccgt ccagaatcat ttcttttatt 2516101 ttccgatgaa acgggctgta gcgatagtta aacgcgacgg tgacttttcc ttcgcttttg 2516161 gcctccgctt caagcacccg attcgcatcc tgcactgttg tcaccattgg tttttcagta 2516221 atcacatctg tattccactg aaggcttttt acaatatatg cgacatgcgt atcgtccctg 2516281 cctgccacaa tgacgatatc aggctttgag acgcgcatca tctcgtcaaa agcatcttcg 2516341 ctaaactcag gcacgtgggc cagctcggga aatttcttct tgcaaacggc aaaacgtttc 2516401 ggatcggcat ccagcaatcc cgtaatctca taatgagttg aaaaccgctc catcagtggt 2516461 ttgataaaca tactgaatgc tctgctgctc aatccgcaaa agacgatgtt cttcaatatc 2516521 ctcacctcta tcgggcttca gttagttgag aaatcagctg cagcgcttcc tctgtttttt 2516581 cagcatacac agggataaac gccgccatat cgcgattcaa ttgaaaagaa tagccgttca 2516641 gctgtttttt ccctttttcg atctgaacgg catagatcgt tttttctcct gtttttttat 2516701 taacagttgt ataaggagat gttttttcag gaggcaatcc gtttaacggc tgaaaatttt 2516761 ccggatcatc gtaagcttga aacatgtctt caggcacgat gaaaacatct ccctcatggg 2516821 cggtaatttc agtcagcagt ttttcctgaa aagctggaaa gatatcgacc ttcccggcat 2516881 tctgctcggc ggcctttttt attttttcct gtacgccagc ctgcatatca gaaaagagaa 2516941 tgacatgcat tccgtccggc ctgcttgagc atgatgccaa aaagagcact gagacgatca 2517001 cacacaaagc cgtacgtatc ctttttgtca tttccccgct gacctaaaaa gaggctccag 2517061 ctctgtcata gctaaaataa acgcgccggc tccgtgcaga tcgtttgtgc ttctttcgcg 2517121 gctgacataa tagtcataga aaccggctga cgttccgaca catatgtctt tgacgagaaa 2517181 cgctccgtct tctgatgttt cggttttatg ctgaatcaag ccttgatacg cttttagcag 2517241 tgttgtttcg taagctctgt ctagatagcc tttattgatt ccttttgcga ttgcgtacat 2517301 gtacagacag gatcctgagc tttccagcca gttatcagac ctgtctccct tatcaacgat 2517361 ctggtaccat aaccccgtct ctttgtcttg atagcgacag atgcttttaa tcatgtcctg 2517421 cagcgtgttt ttccacacat gacggttcgg atgcttcttc ggcagctctt caatcatgtc 2517481 agcaagagac atgacgtacc agccgatgga acgtgcccaa aattccggtg aacagcctgt 2517541 ctcttcattg gcccaaggca tttttttcgc ttcatcccag gcgtgataaa aaagtccggt 2517601 ttttgcatcc ttcgtatgct ttctcatcaa tgactcctga agcacaacct gatcaaacag 2517661 ctccgtctcc tgcttcagat tggcatattt cagtgcaaac ggccccccca tgtataagcc 2517721 gtcaagccac atttggtaag gataaccgtc tttgtgccaa aaaccgccct cagacgtccg 2517781 gttcagtgtt ccatataagc tgcgcagcct ttttgccgct ttgacatacc gttcatcctt 2517841 cgtctgctcg tataatggaa aaagaatgag acctgcttga atggcgtcca gttcatctct 2517901 tctaaataat agattgccat tatcatcgat taagagatct gcataagcct tcgcatactc 2517961 aaaataccgc ttttccccgg ttgcttccca cagccgcaat acaccgcata agaaaacacc 2518021 ctgatggtag tgccagcggt ttgcaggtgg cagctcctcg actgtgtacg tgttcataat 2518081 ggtgtttgcc aatgcctccg cgtacgtaag aggcgatttt acagcgattg attgatccat 2518141 tgatcccatc cctttcctaa taaattcctt cctcgccaaa tttcttcgcc aaacgattcg 2518201 ctagcatgac caaaatcagc ccgaccgccg ctttaaatac gccgactgct gtactgtagc 2518261 tgaattggcc ctgtttcagc cctgcagtat aaacatacgt atcaaaaatt tccgccactt 2518321 ccctgttagt cgcatttaac agcaaataca catgctcgaa gccaagctcc agcgtgtctc 2518381 cgattttcaa aatcagcaaa acgacgataa cgcttttaat ggcgggcagc gtaatatgcc 2518441 acatttgccg cagccgtccc gctccgtcca ttttcgccgc ttcatacagc tgggggtcaa 2518501 ccgctgtaat ggccgccaga taaatgatcg tcgaccagcc cgcttccctc cagataacct 2518561 gcagaatata caggggccgg aaccattctt cgttcagcag aaaattgatt ttttcaccgc 2518621 caaaaaacac aatcagttca ttaatcaagc ctccgtctac cgttaaaagc acaaacgaaa 2518681 gcgatacaac aatgacccaa gacataaaat gcgggatata aatcagcgtc tgaacaaatt 2518741 ttttaaagag agcaatccgc acttcgttca atagaagcgc cagcagtatc ggcaccggga 2518801 aaaatatggc caggttcaaa gcaaataaca cgagcgtgtt ttttaacaag agaaaaaatg 2518861 taggctcagt aaacagcctg ataaaatgct tcagccccac ccactcactg cccaaaatgc 2518921 cgaggaacgg ctgataatcc tgaaacgcaa tcacaattcc ccacatcggg acatacttaa 2518981 aaagcaaaaa ataaatacac cccggcaaaa tcatcaagta caaatatttt tgttgaatca 2519041 gcttgattag taagcgcttt cttttttctt ttttaaaaat gactgcatca acagccggcg 2519101 cttgcgcttc tgctgttttc attttttcct agcctccttt cacggattct tgcattcact 2519161 gtagcgcagc aggcaaaagt ccgtctacaa tcatatgatc acatcctgtt ttatcccttt 2519221 ataatcaagg gttcagccgg tccacctgaa aaaaagacac cgatattaga aaatgattat 2519281 tgacaatatc tatcaatctt tggattaatt gtattaaggt gaagtggatg ttatgaaatg 2519341 gggggtttta tgaaaagaag ccaatacaag ttttactaca aactgatcac gtttttctgc 2519401 ctgctcagca ccattccggt tattttggtc ggattatttt cgtacgagca ctctcagaaa 2519461 acggctattt ccaacgtttc ggaggaaaaa ttcgacacac tccagcagac ccagcaaagc 2519521 atcgagcata tattgaaaac cgtcgatcac tctttaaccc actatgtgag ttcgccgcct 2519581 ctccttcgca cattgtccga gcctttgcac tcagaccaat ttcaaatcta taaccaagtg 2519641 aaccaagagc tcaattatct gcaaagcttt gataccgatc tgtccaacat gacgttagtc 2519701 agttatacga aaaaatggta catgaacaat tccggtttgt accgtttgaa tacagacact 2519761 cttcatgaag cagcctcagc gtacacgaaa caaaaagcga gccgctccta ttggacgctt 2519821 gaggaaaaca atcatttgat ttcaaccaaa gaaggcacag cagaaaactg ccgctacaat 2519881 atcaatttaa ttaagcagct tcctttgaac agcacaaata caaagggatt ggccgccgca 2519941 agcatcccga gctgttcgct tgtcaaaaat atgcccggct attcaaacgc caacaacctg 2520001 tttatcatcg atgaaaaagg cctcatcatc cttcataaca atatgtctga cgttggtgaa 2520061 tctcttcata acgacggctt tgtccaaaaa gtgctggcgc aaacggccaa tagcggacag 2520121 tttgaaacag tgattgaccg gattcattat aaagtcacct atcaaaaatc tgactataat 2520181 gcatggactt atttttctct cgtttccctg cctgagttaa aaaaagaagc caaatcaatc 2520241 ggctggatca cttttgcagt atgcctcatt ttgttaacgc tttcattgct gttctcttgg 2520301 cttggctccc gccattttta caagccgatc agggtgcttt acgaatcatt cgcaagacat 2520361 ggagccatac aagagaaaca acagcctcct caaaatgaat ttgagttaat tgaacagagc 2520421 tttaagcagc tgaaggacag aaatgacgac cttgaagaaa cgatgaagca gcaggccact 2520481 catctgcagc aatattttat ggtcaggctt atgcttggaa aactgacgga tgaggaggtt 2520541 gataaccgtt ttgaaagcct cggcttaaag caaaattggc ggcaccttgc cctgcttgtg 2520601 ctccaaattg acacactgaa tcatacgcct tatgagaaaa aagatatgga tctgcttttg 2520661 tttgccgtca acagcctgat tgagcgcaac atcccgacgg acaaacatct tgcccccgcc 2520721 gtagttgaca aacagcaggc gacgattttg atcaatcaaa gcgggacaaa ggaagaattc 2520781 atggctgagc tgaatgagac tgcaaggatg attcaggaaa aagcggaagc tgagctgcag 2520841 ctgtctgtca gcatcggcat cagccagccg tttgatgtgc tgacaaaagc gaaaacagcc 2520901 tatgcggaag gctcagaagc gttgaaatat cggctgaaag cggaaaacaa gtcgatcatc 2520961 ttttacgaag accttgacca gaaaaaaacc ttcaaaaccc attttccaaa gcagcttcag 2521021 catgagctgt tcgatgctgt caaagcagga gacaaggaga aagcggataa atgcctgcac 2521081 gcgattttac aagccatttt cacccagaac accaacccgt atcaatttca aatcgccatc 2521141 gcccgttttt tgaaccatgt gattgagctg atgcatgtgc ttgggatcga attgtttgag 2521201 cttgaagaaa acaaaatgct gtatgaccaa atttttgagc tgaaaacgtt cgaggatacc 2521261 gaaaactggc taaagaatga gtttattgat ccgatgacag acaaagtgaa cgcccgcgcg 2521321 gatgcccagt acaaaaatat ttccgacaac atcattcata tcatccatca tgagtttgaa 2521381 tccgaattga cactggacga aatcgcacgc aggctgcatt acaacccaaa ttatttaagc 2521441 agtattttca aaaaagaaat gggaatttca ttcagcgagt atgtctcaag ctaccgacac 2521501 catatggcga aaagctggct tgccgaaacc gacatggcgg tcaaggacat tgccgaaaag 2521561 ctgaaatata aaaactccca aaacttcatc agatcattta agaagctgga agggattaca 2521621 ccgggaaact accgccagca aaaaagaagc atgtaaaaaa cccaaaaccg cttgcgcgtt 2521681 ttgggttttt ccaatgttat tttgcttgtt taaacgcttc ttcgtattcc tgaataattt 2521741 gttttcctcc gcttgactcc catttttcca cttctttatc gaactggctt tctgtgatgt 2521801 ctccaatcat atatttgtag gtcgcgtcat caatgatttt cttcagttcg tcaccccgtt 2521861 ccgactccga tgcggaatac aggctttcag ccgggtttga gacgataatc ttttcattgt 2521921 cctcggtcag ctcctcgtac gccgtccgaa gcggatctcc agtgtttttt aagtaggctt 2521981 tatcaatggc aattaaagcg gacagcggct gaatatcagt ctgccagtct tttacctggc 2522041 tttctttgcg tgtaaacgtt ttgtcctcac ctttgttgta atgaacgccg tcaatgccat 2522101 aagtcatcag gctatagaca tcttcttcgg caattcggtc aaaaaacgcc aagatccgtt 2522161 taagctcagc ttccgttttc acactcgttt tcgggaaagc aaacacgccg ttatggcctc 2522221 ctgatgccca tacccgctct ttcccatctg ggccttttat gcggttgatg atctcgagct 2522281 tcatcgattt atcagaggca tggtcgcgca gattgaccgc atctaccata ttgccaatat 2522341 aaattccggc ttttccttga gaaaacagct cttgctgctg ggttttgctt gtgacgggaa 2522401 aatccttatt catatacccg ttatcacgca gctttttcat atagttcatc gtgtctttgt 2522461 attcctgtgt catgaaatca ggcgtgaatt tgccgcccga ttccttccaa tctgtcggca 2522521 tgccttcata cgagccaatc gttttaaacg cgccgtaaat caagtcatta cggtctgcca 2522581 gcccgaatgt atcatctttc ccatccttgt ccgggtcgtc ctccgtaaat gctttggcca 2522641 cttcataaag ctcatccaac gttttcgggg ttttcaaatt taaattgtcc agccagtcct 2522701 tccgaatgac gatcccctgt ctggaaagcg ggcgctctct gtatatcccg tagagcttgc 2522761 cgtcaattgt cacattttta ttaatgagtt tgttcatttt gtttaagttg ggataatcct 2522821 tgatataatc gccgatttcc caaaacattc ctgaccgaaa ggcattcatg actgacgaat 2522881 ttttaatatc ctggatggtc acgatttgcg gaagattgcc ggctgcaagc gctgcattca 2522941 gcctgtcttc tttcaccgcg tctggaaccc aggtgatgtc gagttctgta tttgtcagct 2523001 tttcaatttc tttaatcgcc ctgtctttcg gcggctgctg gtgatacaaa atcgccatcc 2523061 aagacagctt tacctttgaa tctgggccag ctttgccttc agccgaagac tgatcagttc 2523121 ctttacagcc cgccagcact ccgccgagtg ccagtacaag cacaatcaaa agcaccctcc 2523181 atttgtttcc catcgtaccc ctccgtttca tatttcttta tcctttgaca gatcccagca 2523241 aagctccttt tgcaaaatgc ttttgtataa acggatagac aagcagaaca gggatggtcg 2523301 ccaccactat gaccgccatt ttaatggttt gctcaggcgg cgggctgccc gaccccattt 2523361 cagacatatc cccctgcata ccgcttgata caatgacgat ttggcgcaga agcacctgaa 2523421 ttggccattt tgctgaatca tttaagtaca agatcgctgt catatacgtg ttccaatacg 2523481 tgaccgcata aaatagtgaa atcgttgcga tcgcaggaag agacagcggc agcacaattt 2523541 taaagaatat gcccagatca ttgcacccgt caattttcgc ggactcttcc aggcttgacg 2523601 ggatattttg aaagaagttt ttcagaatga tcaggttaaa ggcattaatg gctgtcggca 2523661 aaataagcgc ccagtaagaa tcgagcaatc caagcgattt gaccacaagg aaagtcggaa 2523721 tcatgccgcc gctaaacagc atcgtaaata cgacgagaaa catgagcggc tgccggccga 2523781 ttaaatcacg gcgggataac ccgtaagcca tcagtgacga aagaaacatg ctgaccgcag 2523841 tgcctatcac tgtcacaaac acagaaacaa gcaaactctt ataaataata tctgttgaaa 2523901 aaatgtagcg ataagcatct agcgaaaaag tggtcggtat taaaataaat tttttcgaca 2523961 cgacttcttc tactgtggca aaggatgctg cgataacatg aatgaacgga agtacgcata 2524021 ttaaagcgaa catcagcaag aaaccataaa tcaacatatc aaacagacgg tttttcagtg 2524081 aatgtgcgat agctcccacc tccctttgta agcgttatca tatttttgga aaccgagctc 2524141 agcatgtgac gatatcgtgt ctaaaatgta gcaaatctgt gattgccatg tctataatca 2524201 tttgaacagt gtccccggcc gggcgggggc tgccgcgaat tgagaccgat aacaaaagaa 2524261 aaagagcata atcttagaaa atgattatgc tccgttctcc tcctcgttca gaagttcagc 2524321 cgtattgatt tgtggcgaaa acccaagttc attcacggca gattcaatgg accatggccg 2524381 gcccggatta tcagagacgg cgtaataagt gccataccgg atgttggtct caatggcggc 2524441 tttgaaaatc gacagcagat cggggtgaga aagcagtgtc tttttcgtcc gttctttttc 2524501 atgcagcgta tccatttcat ctgtcacgac tgttccgatt cgaaggttga ttactgatag 2524561 cttattttcc aaataaaaca aatggccgat ctgttcagag gtcagcttta atacaccgta 2524621 caagtttttt gacagcggat aatcgcttgt tgtgatttcc cgtcctaaga gcgagcgccc 2524681 gtctttttca tatacatctg tgacatgatt gctgctggcg aacacgagct tttgaatgcc 2524741 gagctccgct gccgcacggc acagataata gcttgcccta tagaaaacat ccgtcatttt 2524801 ttcaaactca gcgatgtcca taatatcgta tttgattttc acagcgagta aattcaagat 2524861 ggcatcggta tcttttggaa tcttcttcaa cagctcctca taatttgccg cgtcagcctg 2524921 aatggaagag gctttgccat cgaaatgatc tttatcaagc acagtcactt catagtctga 2524981 aataagccct tcagcaagca gtctcccaat cacaccattt ccgccggcga tcagcacttt 2525041 tttcacgatg ttcactcccc ttttttatag attgcccatt ttcggcgggg ctgacacttt 2525101 tttggcactc acattcttag gcttattcaa aagtcaccgg cagctcctca agcgcccgaa 2525161 atccaaaaag cggccgatac cgccattcaa aatccgcaag attaaggctg ggcattcgct 2525221 gcagaagagt gttaatcgca atttgcgctt ctaatcgtgc cagcgaggac cctaagcaaa 2525281 catgatggcc atgcccgaat gaaagatgcg gattaggact tctcgtaata tcgaagacat 2525341 cggggttcgt gaatatgcta gggtctcgat tagccgctcc taacaaaaga tagacttgtt 2525401 ctccttgacg gatcgtcacc ccgcagatgt caatatcctc tgacgcaact ctggctgtca 2525461 tttgcgtggg gctttcatag cgtaaacatt cctcgactgc ggtaccaata agatctggat 2525521 tttctctcag tttcaaaagc tgttctggat gctgcagcag acaaaggact gaattgctga 2525581 tgagattgac cgttgtctca tgtccggcga tcgccagcaa tatgcacgta gatgccgcct 2525641 cctcttccgt cagcttatcc ttttctctcc ccttcaagag catgctgatc atatcctgtt 2525701 gagggtggcg ttttctcttt tgaatcagct ctttgaaata tgccatagcc tgcacagcca 2525761 taatattgcc ctctgttaat gcctttcttg agcgggtaaa atcaatcgtt tgaatgagac 2525821 tcgcagccca ctcctttaat tgctccctat cttcctccgg tacacctata atgttagcta 2525881 tgacaaaact tgctaaagga aaagcaaagt ccgaaatgac ctccatcttt tttttacctt 2525941 gcacttgatc aagcaaatga tggacagttt caatgatata cggctgataa ctctctgtcg 2526001 ttctcggcgt aaacgctccg ctggcaagcg tccgcaatcg tctatgatca ggctggttct 2526061 gaaacagcat catttgattt tgcacatgtg aaaggtcctg atatttggtt gagctctcag 2526121 gcagcggggt gcggactttg aatctcgcat ctttcaaaat agcagccgtt tcttcatatc 2526181 ctgtgacata ccagcccggg tattttaaga aactcccttt atagatagga tgaacagctc 2526241 gcaatgtgtc gtaaaaagaa tatgggtttt tcaaaaactc agaagatgca gttgacgatg 2526301 caattgtcac gtgattttct cctttctgtt caaaaataaa aacaatcgac atcataccga 2526361 ttgcttttat tgattctttc agcttttcgc acttaaacta gccttcattt cttcgactga 2526421 ttcaacttca aagcctaaat cactcagcat tttatgatcc tccgtctcct cttgcccggc 2526481 agttgttaag tagtctccga caaaaatgga gtttgcggcg taaagcccta atggctgcaa 2526541 tgtgcggaga ttgacctctc ttcctccgga aatgcgaatt tcttttgatg gattgataaa 2526601 acggaacagc gccagcactt ttaaacaata cagcgggttt aattcgttga cgccttctaa 2526661 cggcgtgcca tcaattgcat gcaaaaaatt cacaggaatg gaatccgcgt caagagcctt 2526721 caagcttttg gcgatgtcaa tgacatcctg tttcgtctcc ttcatcccga taatggcgcc 2526781 tgaacacgga gacagccccg attcttttgc gatttcaacc gtattgactc tgtcatcgta 2526841 tgtatgtgag gttgtgatgt ttgaatggtt tctctgtgac gtattcaaat tatgattata 2526901 gcggtctact cctgcatctt tgagccgctt cgcctgctct ggcttcaaca gtccaagaca 2526961 tgcacaaatc ttcagtccat acgtctcttt aatttcctga accgcatcta cgacctgatc 2527021 cacttctctg ttagacggac ctctgccgct tgccacgata caatatgtgc cgatattcag 2527081 atcgtgcgcc cgcttcgcgc cttcaagcag cgtttcctta ttcaccatcc ggtaagactc 2527141 aatcggcgct ttcgaaatcg cagactgtga acaatagccg cagttttccg ggcagagccc 2527201 ggatttcgca ttcataatca tattgagctt tacttttttt ccgtaaaagt gttttctgat 2527261 gtgaaaagcc ccgtgcatta atagcaaaat atcttcatca ggacaatgta atattgaaag 2527321 cgcctcttcg tcagtcactt ctgctccagc cagcacccgg tctgcgagtt ccatccattg 2527381 attcattctc atacccccac ttgattcatc agtaatgata gattgatatg gtcttttacc 2527441 atatgtagaa ccgtttcttt cgtcacgttg gcaagctttg gcgtaacccc taaaatcggc 2527501 acaccgcata agcgctcaat catctcagga ttggtttttt catcttcatc aggagagtca 2527561 ctgattccat tgatgataat tccggcgatt ggaagcccca tgctttctgc atatttgaca 2527621 gttaaaaagg tatgattaat ggttccaagg cgaggacgcg ccacaataat catgggaagc 2527681 tgcaacgctt ttatgacatg actgaccaaa tagtcctctc ccaatggcac agaaataccg 2527741 cctgcacctt ctacgatgaa gcattcatgt ttttctctaa tccgccccca atggcttaaa 2527801 acctcttcca tggtgacagt ctttccctca agtttccctg caacgtatgg tgcaagcggc 2527861 gccttgaagg caaaaggcgt aatgtcttca tgagaaagac tggtctgcga catatctttc 2527921 agcaaacttg tatcactatc tggatgatgg cgcgatatcc cgcttaaaaa tggtttatac 2527981 accccgacat gtctattatt gtctttcaat aaggcagcaa gaccgctgga tataaccgtt 2528041 ttccctactt ctgtatcagt tcccgtcaca aaaaaacccc tcaaatgatg tgcagctcct 2528101 ttccgattga atgaaatgtt tgcagcaaat gatcaatatc acccatactg tggtcagacg 2528161 tgattgtaat tcgaatccgg ctttcacccg gcgcaacggt tggcggccga atggcaggag 2528221 cataaattcc cttgccctgc agtttttcag caaataggac cgttttatgg gcatcgccaa 2528281 tgactacagg aataatcggt gtgtgatctc ctttcaccac ataacccata ttcttcagac 2528341 tggttctgat catgctgata taagaaaata aaagctgtcg tttttccctg ctggcttcaa 2528401 tgatgttgaa agcctcgtga gcagccgcac agctggctgg cggaatagcg gtttgaaaga 2528461 taaatgttct ggcatggttc agcaaaaagt cgatgaagac cgctgatcct gccgcaaaac 2528521 ctccttccgc gccaacagct ttgcttaagg tgccgataac aatgtcggga caaacaccaa 2528581 agtattcact cgttccttgt cccgaatcgc ccaaaactcc tgttgcgtgg gcatcatcaa 2528641 cgaccacgaa ggcatgatag cgtttcgcaa gtgagatgat ctgatcaaga ggggcgattg 2528701 tgccatccat gctgaatact ccgtctgtta cgataaaacg gcgctgataa cgctgtgttt 2528761 cattcagctt gttttcaaga tcattcatat caatatgccg ataaacaact gtatcagcct 2528821 tagaaagtcg gcagccgtcg atcatacttg catgattgag ctggtcactt aaaatgacat 2528881 cttccttttc tggcaaggat gaaaggacac cgacattggc caagtaaccg ctcgaaaaca 2528941 gcagggccgc ttctgtcagt ttaaagctgg caatcttctt ttctagcttt tcatgccaga 2529001 ccgaattgcc tgtcgttaaa cgtgaaccgc tgcttcctgt cccaaattgc tgcaatgctg 2529061 tttgggctgc atcgatcaaa cgtctatcgc ttgcgagccc taaataattg tttgaggacc 2529121 agaccgtttg attttcgcca tcaatattcc tctctggaac cggcgctcca tccattgacc 2529181 gcaggttacg atgtacgccg gcttctttca ttctgtctaa ccgctcgttt aaccaggaat 2529241 caatcttcaa ggctcgtaac ctcgtggatc gcttgtttca taatggcaac catttccgag 2529301 agctcttcag ctgtgctggc aagaggagga agaaatgcaa tcacgtcccc aagcggtctt 2529361 gtcagcattc ctaactctct catttttaag gaaactttgt atccaatccg ccgatcagcc 2529421 gggtaaggtt ctttagtttc ctttgatcgt acaagctctg caccgcacat aaagccaagc 2529481 tgccgaatat ccccaacatg aggaagagcg tgcagatctt gaagaagaaa atggagcttt 2529541 ttactttttt ccgctacttg ttccacaatg ttttcagatt caaataatgc cagattttca 2529601 agcgcaaccg cacagccaag ctgattgcct gtataggaat ggccatggaa aaaggttttt 2529661 aggttttcat aatcatcata gaatgcctta tagatgtctt cagtggcaaa cgtaacggca 2529721 attggcaaat agcctcctgt aatgccttta ccggcagcca tcagatcagg ctggacattc 2529781 tcgtgctcgc acgcaaacat ttttcctgta cggccaaagc ctgtagcgac ttcatcaacg 2529841 atcattaaga catcgtatgt tgtacatagc tcgcgcacgc ctgccaaata tccttccggc 2529901 atcacgatca taccggacgc gccttgtacc attgattcaa tggaaagcgc ggcaatttcc 2529961 tcatgatgtt cctcaagcag ctgtgcaagc tctcggaggc actgatcacg gcactcatca 2530021 ggatcaccgc tttcagaacg atacacataa ggaatcgggg ccttgtaact ctcgaacatc 2530081 aacgggccgt atacgtggtg aaaaagctca attgaaccga cactgacggc gccaatcgta 2530141 tcaccgtgat acccgttttt cattgcgatg aatttttgtt tctcgggctt cccgatgttc 2530201 ttccaatact gaaacgccat ttttagggct atttccatcg cctctgcgcc gctgtctgaa 2530261 taaaagaccc gcgtgagctt ttttgggctg atgtcgatta atgtttcggc aagctgggtt 2530321 gctggaacat tggtcatgcc caataacgtg gagtgcgcaa tttttccgag ctgttttttt 2530381 atggcgtcat ctagttcttt tttgcggtgt ccgtggacat taagccaaac cgatgaaaaa 2530441 ccgtcatagt attccttgcc gtttatgtct ttgactttga ttccagtccc gctttcgatg 2530501 attaaggggt tttcatcata atctttcatt tgggtaaatg gcagccagag gtgcttttta 2530561 cttttttcta tcaaatcatg agtcatgatc ttcctcccac tctattaaaa taggctgctt 2530621 ctccaggtca tgtatgtacg tgtttacatc attggatcca tcaataaaaa agactcggca 2530681 gccctcttca gtcccgtatt ctttcattgc tgtaatacgc tgatagccca ttttcttacc 2530741 cgcaacatag cctgttatgt aatccggatc gtccgaccag cataattctg caacgactgc 2530801 cgggtgccgg cttacctttg aagcgagcgc aagggcctct tttattcttg aatgagctgg 2530861 cacgtgactg tgaagcgccc atttttcaaa attagcgtcc ggccaatcca ttctggagac 2530921 ccgcacccct ttttcttttg tttgatccat tcgcttgcct gtatgaatat caaacaacac 2530981 cgcacccctg acatctgacc attcagggat ttgttcatat gctttttcaa tcacgtctcg 2531041 tgaaacgcct tctttttcca ataacaatcg ggcaagcttt tgtccttctt ccgggcagct 2531101 cacttcattc gtatgcacag gcaatggctg aatggttttt atcgattcat gtacctcttc 2531161 aaattgaatt tgcataaaat caggttttcc tcttgaatgg gataaccctt tttctaataa 2531221 agcattgact gtatgcttca tctcatggaa aggaataagc cgttctccgc cggatatatg 2531281 ctttccgccg tcttcatgag atccattcat tgaagccctc attctgacac tataaaaagt 2531341 ttcttcttgc atcatttctc gccctttcac tgataactga agaacgtgta gcgcttctca 2531401 cctaaattgt taaccaatta tattcaaagg ttaacaatta gaatatatta ttctctcctg 2531461 tttctgtcaa tagaagaaag gatcgattta tggcagttgg ttaaaaggaa acaaaaagac 2531521 cgttttcaca caaaacggtc tttttcgatt tctttttaca gtcacagcca cttttgcaaa 2531581 aaccggacag cttcatgcct tataactgct gtttcgaaat gtcccgaagc agaacggacc 2531641 actcggtagc aatcagcagc tccctgtcca gcatagacag ctgtcaattc tttttcgatt 2531701 ttgtccacgc cctcagccgg cgttaaccga tcgtgtacac caacaagact aaggtgcggg 2531761 cgcggcgcga tcaggctttg gatctccgat gcggaaaaat gctttgcaag cgatgggacg 2531821 taataataaa agccgtgcct gtcaagattc tgtgttttga tcagcacgtg atgatccacc 2531881 tggctgcaca aatccacaca caccttaatc cggtcatcga gcgccgctgt ccaccacgcc 2531941 atcaaacctc ccatagacat gccgatggtt ccgatcctgt caggctgaac atcagagcgt 2532001 gactgcatat agtctaacgc acttaaactg tcataaatca tcatccccca catcactttt 2532061 ccggtgagaa gcatttcttt aaatatctcg ctttccgctt ttccccgccg atctccaaac 2532121 ccccaatgat caatcgcaag aacgccgtat ccgagtgaag taagctcatc agaaaaagaa 2532181 ggcgttttca aataatccgc tccctcaatc agctcacttt ttcccctatc atactggcct 2532241 ccatgcgaat gctgaaacaa tacggctggg cacggtcctt ctgttttctt cggcttcaca 2532301 aaataagcgg gcgccttttc atgtccattt aaatcgagca ggagcgtttc aacgatattt 2532361 tcttctcttt cttcaatacg taatgtctca acactgattg gcctccgatc aggcaaatca 2532421 ccaagcaatc gaaacagttg ctttcttctt tcggctctca tcccatcacc cttccttatt 2532481 cgcttacttc acatttacga gacagatctg ggttcccctt tatttttcca acataaatca 2532541 catcatttac taaatattta gtaaatatta tggaatattt cgaaaacaat tattgtaacc 2532601 gcttactttt atatgataat atcaatttat caaaaacaga tgagttaata ttttactaaa 2532661 tagatgagag ggatacccat ggttcgtatt aaagatatcg ccttgaaagc taaagtttcc 2532721 agcgcaactg tgtccagaat tttaaatgaa gatgagtcgc tttctgttgc gggcgaaacg 2532781 agacaaagag tcatcaacat cgctgaagag cttggttatc aaaccgttgc caaacgccga 2532841 aaatcccgcg ggcaaaaaca gcgggctcag ccgctgatcg gtgtgctgag ctgtctgtcc 2532901 cctgatcagg aaaggcagga cccttatttt tcttccattc ggaaagggat tgaaaaggaa 2532961 tgctttgaac aggaaatttt cattacaaat tcgattcatc tcggctcctt tcaggaacat 2533021 atctttcggg aattggatgg tgtcattgtc atcggccgtg ttcatgatga agcggttaag 2533081 catatcagcg ggaggctgga gcatgccgta tttatcaatc attcaccaga tccgcaagca 2533141 tacgattcga ttggcatcga ttttgaatcg gcttcacgcc aggcgattga tcaccttttc 2533201 gacttaggct acaaacggtt aggctacatt ggcggacaag aaaaagagca tacgctgaag 2533261 gacggccaaa gcattcgcag aacgattgaa gataaacgcc tgaccgcttt tttggagtca 2533321 gccgcccccc agcctgagca tgtgctgatc ggagaataca gcatgcgtga gggctatcgc 2533381 ctgatgaaga aagcaatcga tcaaggccat ctgccggaag cattctttat tgccagcgat 2533441 tctatggcga tcggcgcatt aaaagcgctg caggaagccg gactgcaagt gccgcgggat 2533501 accgcaatcg tcagctttaa cggcattgag gaagctgaat ttgccagcac gcctttaacg 2533561 acggtgaagg tatacacaga ggaaatgggc cggacaggcg taaaactgct gcttgaccgt 2533621 ctcaatggcc gaacgcttcc tcaacatgtc accctgccta caacattaat cgtaagacaa 2533681 agctgcggat gtacagcaaa ggaggtgaca taagcaaaga ttcatcacga tgataaggag 2533741 gaaaagatga aacacacttt tgttttattt ctctctctta ttctgcttgt tctgcccggg 2533801 tgttcagcag agaaaagctc agcagatacc gcaaaaaaga cgttaaccat ttattctaca 2533861 atgtcaaccg acagtgaaag agatacgttc agaaaactag cggcagcatt cgaaaaggaa 2533921 cacagtgaca ttcatgtcag ccttcatttc ccaggcaatg actatgaaaa tatgatgcgt 2533981 gtcagaatgg cggccaatga tttgccagat ctattcgata cacatggctg ggggaaaatc 2534041 aggtacggag aatatacagc ggatctccgg gatatgaaat ggactcaaga tcttgatccc 2534101 aatttaaaca gcatcctcaa aaataaaagc ggaaaggtgt atgcctatcc aatcaatcag 2534161 gcaaaagacg gtctggcgta taatcgcaat attttagacc gttacggcat tgctccgccg 2534221 gaaaccatgg atgactttat caaagcactg agaacgatta aagaaaagag caagggaagc 2534281 attgttccct tctggtttgc cggatatgac aaaagctcat tcgcccaata ttacgaccaa 2534341 ttcgctacac ctcttctcat cacagaccct gcccataatg aaaaaaaaca gctcatcaac 2534401 ggcacttttc aatggagtaa attcacttat ttatcagaaa tcctcaaaca aatgcagaaa 2534461 gaaaaattga tcaatatcga cgccgtcacg gcaaaaaaat cacagctcat tgaattaatg 2534521 gcccaaaaca aaatcgcctt tacaatgcaa ggcggcacac tcggccaaga cgttgcccag 2534581 atcaacccga acgtcaaggt cggcattatc ccgacacctg ccatccatcc cggtgatgac 2534641 ccgatatgga tcggcggtga acgctacacc cttgcagcat ggaaagattc gcctcaatta 2534701 aaagaggcaa aagattttat cgcatttatg gcccgcccgg ccaatgccaa acaaatggct 2534761 gaagccacat cgcttccttc agggctgacc aatgtgaaag ctgatatttt ctacgcaaac 2534821 gattatgagt attatcaaga tgtcaaagtc gagccttact tcgaccggtt atacttgcca 2534881 aacggaatgt gggatgtcct gggcacggtt gggcaggagc tcgcggctga cattttggcg 2534941 cctcaagaca tttcgcagaa gctgggaaga gaatataaac gactccggga gcaatccgaa 2535001 acacagggag ctgaaaacaa tgagtgagat cgcaagggac gttcatgtga aacaggttaa 2535061 gccaaaaaag cagtcctcac tttggtggat gtacattcct gctttgctct ccgttctggt 2535121 ctttatgatt tacccgtttg tgaaaggcac attgattacc tttacaaact ggaacggatt 2535181 ttcacaagtc taccaatggg ttggattcgc gcaatatgaa aggctgtttt ctgatcctga 2535241 tacttggcat atcttaaaaa acacgctgca ttacgggctt ggcagcacct tttttcaaaa 2535301 tgtggtcggg cttctgtacg ctctcctctt aaatcaaagc attaaaacga aagcggtaac 2535361 aagaacaatt gtgtatttgc cggtgatgat cagcccgctc attatgggct acatttggta 2535421 ctttttcttc tcctatgacg gaggcgcgct caacgatttg ctcggggtct tcggcatcag 2535481 ccctattaat gcgctcgcca gtccctcgct caatccatgg atcattgtca tgattaacac 2535541 ctatcaatat gtcgggatcg ctatggttgt ctacttagcc ggtctgcaaa gcattccgaa 2535601 agactactat gaagcggcgc aaatggatgg cgcgaaacaa ggccagcagt tttttaccat 2535661 cacgctgccg ctgttaatgc cctccattac cattaatata gtcatcaaca ttatcggagg 2535721 cttaaagctg tttgacgtca tcattgcact caccgcaggc ggccccggaa atgcgtcaca 2535781 atccatgtcc acgtttatgt atgatttgta tttcaaacgg caggatgccg gctatgccgc 2535841 aacgcaaggc atatttatgg catttgtcat tttgatcatc agcttttgcg cgcttgcgta 2535901 ctttaaaaga aaggagacgg aaatgtcatg agagccgccc gtacaaaaag catgcggatc 2535961 attacgcttc ttgcagccat tgtggcctgt gcgcatttta ttccttttta tatcctgctg 2536021 accacttcat tgaaagcaaa aggagactac agttcgaaat ggatatttcc agccgacatc 2536081 tcctttcata atttttcaga ggcgtgggag cgcgcttcgc taggaaactc ttttataaac 2536141 accatgatca tcacaggttt ttctgccttg ttattaatta tattcggctc acttgccgcc 2536201 tacccgcttg cccggcggga aacgaaactg aataaagccg tttttgcctt gctgatttcc 2536261 attatgatca tccctccgtt aacgtccatg gttcctttgt accgaatggt cgtggacgcc 2536321 ggaatggtca atacacacgc aatcgccatt ttcatcaata cagcggctta catgccgtta 2536381 accgtattct tatattcagg ctttatccga tcgaccattc caaaagagct tgtagaagcc 2536441 gcaagaattg acggtgcagg catgctgaaa atctttttta cgattgtgtt tcctctgctg 2536501 aagccgatca ctgcgaccat ctgtatcatt tcttgtgtct ttatttggaa cgactatcaa 2536561 tttgccattt tctttttaca agatcaaaag gttcagacat taacagtagc catggcaggt 2536621 tttttcggag aaaacgcaaa caaccttcat ttagttgccg cagcggcact tatggcaatg 2536681 ctgccgatgg ttgttctgtt tttggcgctg caaaaatact ttattgccgg cctgtcttcc 2536741 ggagcggtaa agggttaaca ttaaaggggg aagcaatatg aaaaagatta catttatcgg 2536801 tgcagggagc acgattttcg ccaaaaatgt tttgggagac tgcctgttaa cagaggcact 2536861 gaatggattt gagttcgctc tttacgacat tgatcccaaa cgcctgcagg aatcccagct 2536921 catgctcgaa aatctaagag accgttataa cccaagtgtg gccatcaaca gctatgatga 2536981 cagaaaactc gccttgcaaa acgcaggcta tgtcatcaat gcgattcagg ttggaggata 2537041 caaaccgagc acagtcatcg atttcgagat tcctaaacgg tatgggctgc gccagacgat 2537101 cgccgataca gtaggcatcg gcgggatatt cagatctctc agaacaatcc cggtcttatt 2537161 tgatatcgca aaagatatgg aggaaatgtg ccctgacgca tggttcttaa actatacaaa 2537221 tccaatggcc actcttacag gcgccatgct ccgctatacc aatatcaaaa caatcgggct 2537281 ctgccacagt gttcaagtgt gcacgaagga tttatttaaa gctctcggaa tggagcatga 2537341 cggaattgag gaacgcattg cgggcattaa tcatatggct tggcttttgg aagtcaaaaa 2537401 agacggcaca gatttatatc cagaaatcaa aaggagagcg aaagaaaaac aaaaaacaaa 2537461 gcatcatgat atggtgcggt ttgaattaat ggataagttc ggctattatg tcacggaatc 2537521 gtccgaacat aacgcagagt atcacccgta ctttattaaa cggaattacc ctgaactgat 2537581 cagcgagctg caaatcccgc tcgacgaata tccgagaagg tgcgtcaagc agattgaaaa 2537641 ttgggagaaa atgcgggatg atatcgtcaa taataaaaac cttacgcacg aacgctcaaa 2537701 ggaatatggt tcaagaatta tagaagcaat ggaaacaaac gaaccattca ccttcggagg 2537761 aaacgtcttg aatacagggc tgatcaccaa ccttccttca aaagcggttg tggaagtgac 2537821 atgcgtcgcc gacagaaaaa aaattacacc gtgcttcgcc ggagaactgc ctgagcagct 2537881 tgcagcctta aaccggacga atattaatac acagctgatg acaatcgaag cggctgtcac 2537941 acgaaaaaaa gaagcggttt accaagctgc aatgcttgat ccgcatacaa gcgcggagct 2538001 ttccatgaag gacatcatct ccatgtgcga cgatttattt gcagcacacg gcgattggct 2538061 tccggaatac aaataaaaac taggggaccg ctctccccta gttttttggt tttgtttcgc 2538121 cttcccaggc catcatgccg ccttcaacat tgactgtttt aaagccttgc tcatccaggt 2538181 acttgcagac gttcatgctg cgcattcctg agcggcagat aaatacgtac tctttgtctt 2538241 tatcaagggt ttccattttt tcaggaatat cccccatgcg aatatgaacg gcttgcggga 2538301 tcatgccttc cgctacctct tcatcttctc tgacatcaat taaatataat tcttcgtccg 2538361 cctcaatttt ttctttcaaa gcggctgtgc tgatttcttt tatttccaaa gaaaacactc 2538421 ctattcacag tgatcatgtt cagtatatca aagtcagccg aacgattgct attctgagac 2538481 tgatgaaaaa aaatcccctt ttggcaaagg ggattttttc taggcttagt ttgccacaat 2538541 attgacaagc ttcccaggca ccgcgatgat tttccgaatc gttttgcctt caagctgctc 2538601 tttgaccttt tcatctgctt gagcaagctg ttccagctgt tctttcgttg catcggcagg 2538661 aacctgtaat ttcgctttta cttttccgtt cagctgaaca acgatttcaa cttcatcatc 2538721 cacaagtttt gtttcatcat atacaggcca agcttcgtag gcaattgtgc cggaatggcc 2538781 aagcttctcc catagctctt ccgctaagtg tggcgcgaca ggagaaagaa gcttcacgaa 2538841 gccttccata tattctttcg gcagttctgt tgctttataa gcttcattaa taaagaccat 2538901 cagctgggaa atacccgtgt tgaaacgaag gccttcataa tggtctgtga ctttcatgac 2538961 cgtttcatga tagacgcgct ccaatgtttc acccgcgcct tcaacgattt ttccattaag 2539021 ctcaccgctg tcttcaataa ataggcgcca tacacggtca aggaaacggc gcgcaccgtc 2539081 taatcctgat tcagaccagg cgattgaagc atcaagaggt cccatgaaca tttcgtacaa 2539141 tctcagcgta tcagcaccgt gagaggccac gatttcgtca ggattgacaa cgttcccttt 2539201 agatttactc attttttcgt tgttttcgcc gagaatcatt ccttggttgt acagcttttg 2539261 gaacggttct ttcgtcggca ctacgccgat atcataaagg aacttatgcc agaagcgggc 2539321 atacagaagg tgaagcacgg catgttctgc accgccgata tacatatcga ccggaagcca 2539381 tttttccaat ttttctggtg atgccagctg atccggattg tgcggatcaa tatagcgcaa 2539441 gaaataccag cagcttcccg cccattgcgg cattgtattc gtttctcttc ttcctttttt 2539501 ccctgtctca gggtctgtga cttccaccca ctctttaatg ttcgcaagcg gtgattcgcc 2539561 cgttccgctc ggtttgattt catccgtttt tggcaaaatc agcggcagct cctcttccgg 2539621 gacagctgtt gacgttccgt cttcccaatg aatgaccgga atcggctcgc cccaataacg 2539681 ctggcggctg aagagccagt cacgaagacg gtacgtcact ttcttctcac cgtttttcgt 2539741 ttcttccagc caagcgatca ctttttcaat cgcttcctgt ttgtgaaggc cgttcaggaa 2539801 atcagagttc acgtgctcgc cgtcgccagt ataggctgct tcctcaacgt tcccgccttt 2539861 tacgacttcc ttcaccggaa ggccgaatgt tttggcgaat tcaaaatcac gctcatcgtg 2539921 tcctggaact gccatgacag cacctgttcc gtatgatgca agaacataat ccgcaatcca 2539981 aatcggcagt ttttctccgt ttacaggatt gatcgcatac gctcctgtaa atacgcctgt 2540041 ctttgttttc gcaagatctg tgcgttctag gtcactcttt gattgaattt ctttgatata 2540101 agcttcaaca gcttcttttt gctctgccgt tgtgatgttt tccaccaatg cgtgttccgg 2540161 ggcaaggaca gtgtatgtag cgccaaacag cgtatctggt cttgttgtaa acactgtaaa 2540221 ggaatcatca tgtccatcta tagcaaaatg aacgtgagcg ccttccgaac ggccgatcca 2540281 gttgcgctgc atatctttaa tgctttccgg ccaatcaagc tcttccaagt cctcaaggag 2540341 cctgtccgca taagcggtga ttttcagcat ccactgcttc attgggcgtc tctctaccgg 2540401 atggccgccg cgttcgctct tgccgtcaat gacttcttcg ttggcaagaa cagtaccgag 2540461 cgcagggcac cagtttacag gcacttcgtc aacgtaagca aggccttttt cgtatagctt 2540521 taagaaaatc cattgcgtcc atttatagta ttcagggtca gtcgtattga tttcgcgatc 2540581 ccagtcatat gagaagccaa gcgcttgaat ttggcggcgg aagttatcaa tattctgctt 2540641 cgtaaacaca gcggggtcgt tccctgtgtc aagcgcgtac tgttcagctg gcaggccgaa 2540701 tgcgtcccag cccattggat gaaggacatc atagccctgc atgcgcttca tgcgggacag 2540761 aatatccgta gctgtgtatc cttcaggatg gccgacgtgc aacccagctc cagacggata 2540821 aggaaacatg tccagcgcgt aaaatttttg tttttcatta ttatcaagag tggcaaatgt 2540881 tttgttttca agccaatatg tctgccattt cttttctatc tctttgtgct gaaaactcaa 2540941 agtaaaaacc tccttctgat tgaatacggc gtgtatggtt caagtattga cgggaaggag 2541001 aggattatat tcagaatatt cccaaactaa aaaaaactcc ctcatcccaa aaagggacga 2541061 gagactttcg ttttcccgcg gtaccaccct cgttagcgcg gcatacgccg cactcacttg 2541121 atacttttaa cgcagttatg cgtcagcggc ttttcaccgc tgcaactctg aggtgagttc 2541181 ggaaacaaac ttgattgact ttcaccagcc gtcaactctc tgcaacaata tctgtttctt 2541241 actgctcctc ttcattgttc ttatcgcaac cgtaatctaa ctgtatttta tagaattctg 2541301 ttcataagtg caagcaggtt tgtatacaat gggaatgtac cctgaacggg cggagattga 2541361 ggacaattat tcgggtggag ttttggtttg acgtttggac tcggccggtt cgccgccgct 2541421 gttcagttct ctcacaaagt caaaacttct gagaacagct tcaccgccgt agcctgagat 2541481 aatggataag atgacaagtt gaattcctga atcggggtca gcggataata caagtaaaat 2541541 ggaagccgtc atgccgataa accaatcttc caaaaatcca aggtagataa accgcttcgt 2541601 cattctgggc ttctccagcc tgcctctctt tttcacatga ccgagaatcc ccatgattcc 2541661 tccaattaca caagcaatga gtacctgatg cagcatcttc atcatcacct tcctaaagcc 2541721 cttatttcgt aaagcgactt caggccatcc agccccctta aacgattccg atgattttcg 2541781 atatctacat accggcaaat ctgtaaaaag cttgtttctt ccattatatg tgaacacatg 2541841 atcggtaagc ttgatgcatt ggattcattt ttcacccagt gacattgacc tagtcaccta 2541901 tttagcatgt agaaaacctt tccgttcata tgttcaaatt ctgttcttat ttttagtgta 2541961 tacgaggaca agccctaatg acaaacaaca aactgcactt gcttgaatca gaacatgtgt 2542021 tgtgctacgg ttactgtaga attcattttt aaaaagggga atatcaggct ttcgcatagc 2542081 aagctgacgg cctaaggggg atttatatgg ctagttttca atcatttggg ataccaggac 2542141 agctggaagt catcaaaaaa gcacttgatc acgtgcgagt cggtgtggta attacagatc 2542201 ccgcacttga agataatcct attgtctacg taaatcaagg ctttgttcaa atgaccggct 2542261 acgagaccga ggaaatttta ggaaagaact gtcgcttctt acaggggaaa cacacagatc 2542321 ctgcagaagt ggacaacatc agaaccgctt tacaaaataa agaaccggtc accgttcaga 2542381 tccaaaacta caaaaaagac ggaacgatgt tctggaatga attaaatatt gatccaatgg 2542441 aaatagagga taaaacgtat tttgtcggaa ttcagaatga tatcaccaag caaaaagaat 2542501 atgaaaagct tctcgaggat tccctcacgg aaattactgc actttcaact cctattgtcc 2542561 cgattcgcaa tggcatttcg gctcttccgc tagtcggaaa cctgacagag gagcgattta 2542621 attccatcgt ttgcacattg acgaatatct tatcaacatc caaagatgat tatttgatca 2542681 ttgatttatc cggattggcc caagtgaacg aacaaacggc cgaccaaatt ttcaagctga 2542741 gccatttgct gaaattgacc ggaactgagt taatcattac tggcattaag cctgaattgg 2542801 ctatgaaaat gaataaactg gatgccaatt tttcgtcgct gaaaacatat tcaaatgtaa 2542861 aggatgccgt taaagtgctt ccgattatgt aaaaagatcc cgctcaccca gctggatctt 2542921 tcagattgtt gacaaaatcc taaaatggtt ttcattttag gattttgtca tcttttcagc 2542981 gtgattgaaa acccttgaag tctaggaagg acgagcatag gagcggagcg aatgttctaa 2543041 ttcgtgagca ccgaagcgca ggcctgacaa cgaatgcgag ggtttgtcga cacgctgaaa 2543101 gatcccgctc attcggcggg atcttttatt atgaagagat tgatgcctgc ttatttgttt 2543161 ctttagctga ttttatccgt ttgtcatata gaagcgttgt ggcaatactg atcagcagca 2543221 ataccaacag agataaaaca agagccctaa tgccgtaatg atcgacaagc actcctccga 2543281 acaggggacc aatcattctg ccgcctgtcg ccgcactgtt gacaaagcct tgataaaagc 2543341 cttctttccc tttaggggca agctgattgg caatagtcgg cacagcaggc caaacaagca 2543401 tttctccgat agtcaggatc accatcgcag cgagaaacat cggaaattgc tttgcagtca 2543461 gcagcatgct gaaagacaca ataaaaatga taaagccgat gaccatttgc gcttttagcg 2543521 actcggccca ttttttcacc acaaaactga cgagcggctg gccgagcaca atgagaattc 2543581 cgttaaccgt ccacagcacg ctgtataagg aaagagatat tccaatgctt tgtgtgtacg 2543641 aagcaattgt ggttgaccac tgagaataag ccagccatcc gagtacatag cctccgctta 2543701 aaatgatcag tgcggcaaat tttgctttgc tgttcacagc atcataatca agcacggatg 2543761 tttgggatgc atcgcccgtt tgaatatttc gaaatccgaa atatacaata aagaaaaaga 2543821 tcagatacaa tacggcattt gccaaaaata catatgaaaa cgagaaagat gccacgacac 2543881 cgccaagcgc tgaaccaacg gccacgcccg cgttttgcgc gacatatatc gcattaaatg 2543941 ccttccttcc cccttcaggc cataccgatc ccgccattgc gtagcttgcc ggaaaaacaa 2544001 caccggagcc aaagcccaca atcgtcagca gcacaatata ggctggccaa tcatgaaaaa 2544061 agacaagacc catcaggctt gctaacgtaa tggctatccc aagcataatc gatttaaaac 2544121 cgccgatttt atcaaacaaa aaacctccgc ataaattgcc agccacactg gcgccggaat 2544181 tcagcatcag gacaagtccg gctactgtta acgactttcc taaatgatta tggatataaa 2544241 tcgtattcag cggccataaa aaagaagcac ccgtcacatt gataaacatt ccaatgacta 2544301 aaattttaag agcacgcggc atactcatcc ccctttctta cctaaaaaag ctcatgaaaa 2544361 aaacgaaacc taaaacggct ccgtacgaat ccagttatca tagcacattc attctatctg 2544421 tctctctcac atttttcaac tgatgagcgt gaaaaaatct aacaaatatt gtttgaaaaa 2544481 tgtaaaataa atagaaaaag gggtcatatt atggaaatgg tattagcatt cttaggtttt 2544541 ctggcatgtc tcattgcact gggctatgga ttatatcacc ttgtcagata tgtactgaaa 2544601 aaggaaaaac gtttctcaaa gagacttttt tggccgcttt tcattggagg ccttgtgctg 2544661 ctctttaccg gggcagcatt ggcagaacct gacactgccg cagcaaatgc cgagaaaaaa 2544721 tattcagcgc taaacgccga atataaaaac ctcacaaaag agcacgaaga acttgagaaa 2544781 gaatataaat ctgtcagctc tgaagcaaag aaattaaaag acaacaaaga agatcaagac 2544841 aagcttgaga agcttaaaaa cgaaaatagc gatctaaaaa agactcagaa atcattaaaa 2544901 gctgagatta aagagcttca agaaaatcaa aagcagctca aagaagatgc aaaaacggca 2544961 aaggctgaaa atgaaacact tcgacaagat aaaacaaagc ttgaaaatca attaaaagag 2545021 acggaaagcc aaaccgccag ctctcatgaa gacactggaa gttcttcaaa caatacgagt 2545081 aaaagtgatg aaaccaaaac agctgacaaa gcagaaggct gtaatatcaa aggaagcaga 2545141 aacggcatct accacacgcc aggcagtaca tactacgacc ggacaaccga tccggctgaa 2545201 atgttttgct cagttgaaga agctgaagcc gccggttatc gggcgccaaa acgataaaca 2545261 aaaagctcca gaatgtctgg agctttttct gtttcacaac gacgatttaa tgaccttctt 2545321 ataataaaga actgacagaa aaccaaaaat ggagtagagc gcagtatata acaccatcac 2545381 cataatcata ggcgcccata cctctgatcc gaataagaac cagccggatt ggacggcaaa 2545441 gtaactgtgg aagaggccga caacgagcgg aatgccgaag ttgtacattt gtttgatgcg 2545501 tatccccttt atcaggtcgc cctgcgtaaa gccgagtttt cttaaaattg tatagctcgg 2545561 tttttcatct tcactttcac ccatttgttt aaaataaagg atacaacctg atgtaatcag 2545621 gaacgttaac cctaagaagc cgacgatgaa catcaccata ccaaacagtg atttttgcgc 2545681 agcgcttgta tctagtcttg ataaatgctc gtttttcttg ttcacctgtt gaaaaagctc 2545741 atttgctttt tccatttgat cgtcatgttt cacattgacg ccgataaatg tagattgcgc 2545801 cagctgaatg cgggggtctt tatccttgtc cagctgttta aacaggctgt catccacaat 2545861 gacagcgggc atgcccccgc ttgtaaacgt gtaggacaca agaaactctt ctcttaatcc 2545921 tttatatttt aatggctgcg tctcgtgctt gctttttact ttaataacac cagagtcctt 2545981 gaaaaccatt attttttgca gcaagtcggt gtatcctgag aaaacggctt ctccagccgc 2546041 cacatcgact ccttttacat ctttgtcgct aacaacagca agctgcatat tgccgggatc 2546101 gccctgcatc tctttcggag ttccatccat aatatttgca atgtcaacat ttgcttgcag 2546161 gacaggtgtt gcctttttta caaacgagat gttgctttcc ctcaatttgt tttcaaataa 2546221 cttggcatct ttctcattca tgaatgaaaa atcagccgct acattttgtt cagcggtctt 2546281 ttccgacgag taatacgaga tgtaagcaag agataacagc ccgatggcga gcgctgaaac 2546341 ggttgtaata atcgtcagca gcagcgcatt cgatttcatt ctgaacatga tcgaagacag 2546401 tgacagaacc tcagaaatat ttaagtagcc gcccttgctt tttcgaatga tattcgagat 2546461 aaacgtaact gatcctttat aaaacaaaaa cgtcccgata atgacgctcc ccagaatgaa 2546521 gctcatcgca acaaacagtt cattaatggt cttaaatttt ccgccaaaca gctcagaaga 2546581 cacatagtat cctgtcaaaa tcaacacgat gcctaaagcg ccgatcagca tttggaaaaa 2546641 tgatattttc ttcactttgt cttcagtgga ggacgttact ttaaacaaag ataaaatact 2546701 ctgttttttg ataaacgtat aattcatgat catgatcaaa aggtaaatgc cgcagaacac 2546761 aatgaccgtt tggaccaagg cctgctcaga aaaatgcagt ttcgcatccg ctttgacatc 2546821 gacaattttg aacagaatca tcaagacaag cttcgatatc gaaaacccgg ccgctacccc 2546881 gatcgctaat gaaccgaaat acagcatgac attttctgca cttaagatgc gaaaaatttt 2546941 atgcttcgtc attccaatta attgaaacag cccgatttct ttactccgtc tcttaataaa 2547001 aatcgtattg gcatataaaa tgaagatcgc cactacagcc acaagcaaaa tcgaagcggt 2547061 tttaatagcc gcggctccct tgattgaagc cttcacttcg ttaattgctg gatcatactg 2547121 cagcgtgaca aaggcgaaat aaagcgccac gctaaagatg agcgcaaaca catacaaata 2547181 gtaattccgg agattctttt tcaaatttcg caggatgagc tgattaatgt tcatgctgca 2547241 ccccgcctaa cacgccttgc gttttcataa tatcctggaa aaacgtttgc ctgtcctggc 2547301 cccctttatt cagctgtgta tacatttgcc cgtccttaat aaaaatgact ctgccgcagt 2547361 agctggcagc gacgggatca tgggtaacca taataatcgt cgcgttgcgt ttttgattga 2547421 gctggctcag cttatttaat agatcggagg ccgatttcga atcgagcgcg ccggtcggtt 2547481 catcagcgaa aataatgctc gggtcatgaa taaacgctct tccagcggat gttctctgct 2547541 tctggccgcc ggaaatttca ttcgggtatt tatcccgcaa ttcatatatt cccagttcct 2547601 tggcaacttc ctcaaacttg cgattggctt ccttttttga tagtttcgtg atcgataaag 2547661 gcagaaggat attctctttc actgtcaatg tgtctaacaa attgtaatcc tgaaagataa 2547721 agcctaaatg ctgttttcta aattcagcca gctgcttttc cttcatagcc gtcatgtcat 2547781 ttccattaat atgaatggtt ccgtgactga cctgatcgat tgaggacaga acgttgagca 2547841 aagtggtttt tcccgacccg gaagcaccca taatactgac gaattcgccc ttttcaatgt 2547901 gaatatcgat gcccttcagc acttcctgtt tattcagctt gtttccataa ctttttcgaa 2547961 ttttattcgc ttctaaaatc accatttacg cagtctcctt tatattggat aatctcatta 2548021 taaaaaggaa tgccgggctt ttccttcgat acggcgaaca aaaaagaaaa gcatgtgaca 2548081 ttttcgtcac acgcttatga catgttcaaa ttgattccgt attggaaagg ttaatgtaaa 2548141 aactgttccc gcaccaaact ccgactcaac atcaatatgg atcaataacg gcgccgctgc 2548201 tttttttgcc aagtacagcc ccatgccagt tgacgcttga tcatggtgat ccgttgtgga 2548261 tgtaaaccct ttatcaaaaa tacgcggtac atcttttgga tcaatgcccc tgccacaatc 2548321 tttcacttgg agctgcgtct gttccccttt ttgaaagctt ttgatctcga tttcagaggc 2548381 ttcgctgtat ttcaccgcgt ttgtcagcag ctgcctgatg ataaacgcca gccattttgc 2548441 atcgctcagc acttctttgg cctcgagctg tatgtcaaaa ccgatccctt tttggataca 2548501 ccacgattgt aaatctttga tttctttaaa gatcaaaggc tgaagctgaa tgaattctac 2548561 tgacaggtcg ttttcaataa atgaaatgcg tttttgatga agctgctgat caagaagcag 2548621 gtgaatacgc agccattcat atgacagctg ggatttcagt gctttttctt ccattctatc 2548681 aatgattaaa tgcatcgctg ttaatggagt tttgacctca tggatccatg ccatcagctc 2548741 atctttttca ttttccaatg ctaagcgatg ccgtgctgcg gtctgcttca agtgttctgt 2548801 ttgcccggca atgcttcttt caaccattgc ttcaaacggc gtttccggtt catttatggc 2548861 tgtcacatcg agattgttct cccatgtttt caagctttta taaaacgctg tttctttccg 2548921 atagcggaac caaaggaata tgataaaaaa caagatgcac aaatacacca tataaagtac 2548981 attcccaaat gatatggaag gatcgacaaa agcaatgaac agcatcaaag cctgctgaaa 2549041 caaaaacgcg gcaatccagc tccgcctttc gataaggaat gctttaatca tagaacttgt 2549101 cctcttcctt cgcgatgtag ccctggccca cctttgtctc gatatatgca ccaagctgca 2549161 gggcgtccag tttttttcgc aggcgattga cattgacggt cagcgtatta tcactaacaa 2549221 aacgctcatc gttccacaag cttctgatca gctcttcccg gctgacgatc ttgttttttt 2549281 gctctattaa ttgttttaga atgaacattt catttttggt cagttcaaca gatcctttgt 2549341 cattgctgac gaggttctgc tccgcgtcta cagcagcgcc gcaccacgtt ttaatcgtac 2549401 tcggctccgt attataatgg tgcacacgcc ggaacatcgc ttggattttc gcgatcagca 2549461 catcaaaatg aaatggcttt tgaataaagt catctgcccc gagctgcatg gacatcacca 2549521 tatcagcagg atgatcccgg gaggataaaa agagaatcgg aacatttgac cgggagcgga 2549581 tcagacggca ccaatgaaag ccgtcaaatt taggcagctg cacatcaata atgacacaat 2549641 caggattaac cgccgcaaat tcctgcagca cctgactgaa atcctgaatg ccgtatacat 2549701 cataggacca tcccgttaaa cgatccttga tttcatgaaa cagcgattca tcatcttcaa 2549761 tcagcaaaag tttaaacaat cgactcaccg cactttttcc ttttttatca agtgtatagc 2549821 aaaacgccag catgcgctat agaaaaagcc ggctgtctca gccggctcgt tcgcattata 2549881 attctcttct caacgctgtc agcacgttgg ttttggtagc ttttctcgcc gggttcattc 2549941 cggaaatgac tgcgacccct ccgcaaatca caacggcaat gatcacaagg ctcgccggga 2550001 tgtaggagaa tgtgtaattc aaatcgcccg catcgccacc gcttgtggcc gcaagaatca 2550061 tcggaacggc caggttgaca aggtagctca cgccgtaaga aatgataatc ccaatcacac 2550121 agcctaaaat tccgatatac gcgctttcca tcaagaacat tcggcgaatg attgacgggc 2550181 tcgccccaat cgctttcata atgccgatct cttgcgttct ctctgtcacc gccatcgtca 2550241 tcgtgttaaa aatgccgatc gctgaaatga taactgcgat acatccgaca aagatcagtc 2550301 cgattttgaa gaccatgaag aaggtattgg ctccctcaag ttcagtagtc actgatgtga 2550361 catagtaccc gtcatctgtt agatcatttg tcagctgttc cacattctca aacttatcag 2550421 caaaaacacc aatgttcgtt tcaacatttc cgcctttgaa atctaagaat tccgaaaaat 2550481 cttttttgaa ttgatcactg ataaaaatat ttgagtcctc catccagtct tgagatggtt 2550541 tttttgtaat accgacaatt ttaaagtcat atgtttttgt ttttgtaaca tcccctgttt 2550601 tagaatctgt cttcgataca cttagttcaa ttgttttatt tagaatatct ttcgtatagc 2550661 cctttggttc ttttatatct tctggatttc cttttgcttc ctcgattttt ttgttatatt 2550721 cttccgattc ttttttcgtt aataatctct ttgcgaagtc gtatcctact acgatttcat 2550781 tttccgactt tgcgactctt cccttttcca attccatatt ggcctttaat tcatcattca 2550841 tattagtaaa aatgagattt gagctttcat ttgtacgatt gcctaaagta gctttgtttg 2550901 gttcatacac ttgcgttctt tctacaactg accttacgtg atcatacttc tctaaatcag 2550961 cttttttaat cggcttgtct ccttccttgc ccattacgct gactttcgtt acaatctgct 2551021 ggctcattgt catatctgta atcgtctttt gaatcccaaa tccaacggac gacaacacaa 2551081 ccaaaaacgc acacgccatt gttgtcgcca gaatcgtcat aaagacgcga agcctgtttt 2551141 tcttcatatt tcttctgata aaatgaacct gatccttaaa cctcaacggt aattcctcct 2551201 tttagcacac catcatgaag ctgaaatttt gaatgtccga tagaagcgac ttcatcatcg 2551261 tgagtaatga tcacaaatgt aatgccacgc tcacgattca gctgctggat caattccagc 2551321 acttcatgtt ccgtttctga atcaaggctt cccgtcggct catccgctaa gataatcgaa 2551381 ggatttaaaa tcaatgctcg agcaatactg acacgctgct gctggccgcc tgacagttca 2551441 ttcggataat gagcggcgtg gttttccaga ccgacgcgtt tcagcatgtc ctgcaccttt 2551501 tgcttccgct cagatggctt gattcctttt aacgccagcg gcatttccac attctcatac 2551561 gtcgttaaac ccgggatgag ctgaaagctc tgaaaaataa acccgaaatg gtcaagccga 2551621 aattgcgccc attccttttc attaaacccc gtaacatcag tgccattaat gacaatccgc 2551681 ccttttgtcg gcgatatgta gccggaaatt aaattcaaaa gcgttgattt ccctgagccg 2551741 cttcgtccga caatgcaggc gatttcccct ttcgccacgc tcaatgaaac atccttcaat 2551801 actggaactt cattctcacg gccctttttt ccgatcgtga aagaatggtc gatatgctga 2551861 acatcaatca tatgttctct ctcccttaca aaagtttcat ttttttataa atcgcaaaat 2551921 aactaatcaa gaaaccgatt accgcacctg tacccatgcc aatgagataa ccggcaaagc 2551981 tctcgcttgc agtaaatcca aaatagccga agcccatgat tcctatgata ataacgatga 2552041 tctgcaccgg gcggttaagc ggcttccata agaagaaata tccgtttctt tcattagaca 2552101 ttttaacaaa gctaatatag ccgatgatgt aaaaaatgat agtcatgata gccggaatga 2552161 ctaaataata tggtgaattc tcagcccatt tcgagtctac ataaattatc ggaatgaaat 2552221 actgcaccca tttaggtact ggaccatgga taaaatctat tgatccgcca aaaaggatct 2552281 cgaggttgat cacaggcagg ctgatgagta aaaacggcga aatggccacg gtaaatgaga 2552341 ctagaagctg tgcgaaacta ttgcctgtca aagctcctcc ggccataacc aaagaataag 2552401 ccagcatgct aacaataatc attcccaagc tgtaattgtg aaaataaacg gcctgatctg 2552461 gcttcaaaag catgatcagc aaaacagaca aaacataacc tatgagctgc ggcaccacaa 2552521 tcaccattcc gccggtaagg aacttcgcat gaaatatctg ccctcgtgta tatggaaggc 2552581 ttaatgtaaa atcaaagaag ctcttgctac gttcaatccc aagctggctg accgccaaaa 2552641 cgactcccca aatccaaaac aatgagataa atgagctatt taaataatca acgctgaata 2552701 cgcaggggcc gacccaattt tcttttccag tgacacagcc ttgatagatg agatacatat 2552761 ttaaaattga taatggatta cctaatataa aaaccaaaat ggtgataact aaggcgactt 2552821 tattctgccg ccactctttg taaagcagtc cggaatccgg caactcactt ccctccaaac 2552881 ctaaggcatt tcttacactt ttgttttctt ataaatagag aagtagctca caaagaatcc 2552941 agccactgct ccaatgatca tacccaaaat ataaccaata atggaatgtc cggtatagta 2553001 tccaaataaa ccaaatccaa ggatgccgaa agccataacc agaatttgca ccgggcgatc 2553061 taatctgttc cataagaaaa agtgtccgtt ccgttcactt ggaagcttct tgaagcttat 2553121 aaagccaatc aagtaaaata gcatgctcat tacggctgga atcaataaaa gatatttact 2553181 gttaatcagc cattcattta caacgtaact aatcggtact aggttcgata aattgcttgc 2553241 cagagagaaa taactctcag gggaagggaa tatttcccat atattcgcac caaaaacaac 2553301 ttctaggttt ccaaccggca atgcaataat taaatacggc aatatagctg ctgaaaacgc 2553361 cgttaacagt tgggcaaaag catttccagt taacgctccg gcggccatca ccagtgaaaa 2553421 agccataaaa cttatcacga ttactccaat gctgctgtgc tcaaaaaagt agacgtgttc 2553481 agggttatag acaagaatca gcagccatgc aagtaaaaag ccaatcaatt gtgacagcac 2553541 aatcacaaaa ccgcctaacc aaaattttgt ctgaaaaatt tggcttctgt tatacgggag 2553601 gcttaatata aaatccatcg tgcctttcga acgctccatt ccgaggaagc agaccgccaa 2553661 aatgacaccc ggcacccagt tgatatctat cagattgctt atggaataat tcacaataaa 2553721 atcacaatat tgcgggtctt ggcgatcaag acacccttga taagacaaat acgtattaac 2553781 gatagaaagc ggatttgcca atactaaaaa cgcgatactt aacaaaatca ccacttgatt 2553841 ctgcttccac tctcgataga ggagacctcg gtctaccatc tccgcttccc tccaaacttc 2553901 gcaatgaaca cttcttccag gttgacagga agctcattcc acacttttgg cttcagctct 2553961 ctcaaaaagc tctttttctc ctcatcgctt ttcggaatca gcactgtgta aaacacgccg 2554021 gcctgatcga gcatcggaat gttttgctct ctgatggcca aattgacatc tgtatcgaag 2554081 gccatttgaa ttttaatgta ttcttctttt aactcatcaa gatccatgac gttggtcagg 2554141 ctgttatctt caagaaaacc aattcggttg cacatccgct ctatgtcttc aagccggtgg 2554201 gacgtaatca ggatgctcgt atcacgctct gccacttcat cgaccatcag ctgcagcaca 2554261 tcatgccttg tcaccgcatc aataccatcc gtcggctcat caaggaggat cagcgccggt 2554321 ctcgccgcaa acgacagaac gagcgatagc tgctttttta agcctgtcga cagctcacgg 2554381 tattttttcg tttccggaat ttcgtatctg ttcatcagct cattcgcgta cgtgacatca 2554441 aatttcggat atattcttct caaaatatcg actaactgct tgtatgtata cttatcgtaa 2554501 aacggatttt gaacaggcat gtagatgata ttttgtttga ctttcgggtg ctttttgatt 2554561 tctacgccgt caaataaaat cgttccgctg tcagcgaaaa tgatttgctg gattaagcga 2554621 agcatcgtcg ttttgcccga tccattgcgt ccaagcaatc caaagatttc tcctttttcg 2554681 attgttaatg aaacatcttt taatacttga ttgccgtcaa tcgcttttga cagctgccgc 2554741 agttcaatca ttttttttgc ctcccttcac atcagcgctg atttccttta tccattcgtg 2554801 cagtttttcc agctcaaccc ctgcatagtg tgcatcgatg atgagctgtt tgagttgctc 2554861 tttaatcatc gtcatcttcc cttcaaccag tgtcgttttt gcattctccg atatataggt 2554921 ccctctgccc cgcagcgttt caataatccc ctctcgctca agttctttat acgctttgct 2554981 gacagtgttc ggattcgcaa taatgatcgt tgccaattct ctgacagaag gaagcttatc 2555041 accaggcttc atgatccctt tcaaacaaag ctctttcatt tgctgaataa tttgttcgta 2555101 aatgggtgtt gagcttcttg gatcgatttg aatcatttac ttccctactt tctatacgat 2555161 ctgaaccttt tatagataaa aatgatcaat tatacttttt tgccattcaa aaccgatcat 2555221 cacaagaaca agaaaaaaag aacaagcgat cacagatgcc gcaatcagca ttggcacgtt 2555281 acgtttgttt cgttttttat gtttcataac tgcctccctt aatgtcaata tataaatgat 2555341 tttatattag tgtctatagt gtattacttc aattagtaca cttaatacaa taaatacttt 2555401 gactcacaaa gtcaatcctt tttttacaaa aaaacggacc cttttaaaag ggtccgtttt 2555461 cctacacatc aagagggtgc tgcaggatca tattattttg caaagattga agctgaagtc 2555521 tcattctgta cagctgttct ctctgctgat catttgacga cagccatagt ttattcaagg 2555581 catttaccgc atcttctagc tgcatttgtg catcactata ttcttgatcg ttataatgct 2555641 cttgtttaga agcgattttc agctgttctt cagcataatc ataggcctgc atacattgct 2555701 ggagatgttc atctactgat tgtcttgttg ccacagtaac ccctcctctt ggtaatggaa 2555761 atcatccatc attcatattg tagcctcatc tgactttatt caataaagta atttatggtc 2555821 gatattcatt tgttctcttg tgaaatgcgt gctacaattt taggatgcaa tcgtacgcaa 2555881 ggaggcacat gaattgtgat gcagaacaat ccttttcctt attcaaatac ggaaaaacgc 2555941 tatcatacat tgaattatca tctcagagaa catttcggcc ataaggtgtt taaagtagcg 2556001 cttgacggcg gttttgactg tccaaatcgg gatggcaccg tagcccacgg aggctgtacg 2556061 ttttgcagcg cagcaggctc cggagatttt gctggaaacc ggaccgatga tttaattacg 2556121 caattccatg acatcaaaaa ccgcatgcac gaaaaatgga aggacggcaa gtacatcgct 2556181 tattttcagg ctttcacaaa cactcacgcc ccggttgagg tgcttcgtga gaaattcgaa 2556241 tccgtcctcg ccttagatga tgtggtcggc atttcgatcg ccacacgccc ggactgtctg 2556301 cctgatgatg tcgttgatta cttggcagag ctgaatgaac gtacgtattt gtgggtggag 2556361 cttgggcttc aaacagttca tgaacggact gcacttttga tcaaccgcgc acatgatttt 2556421 aactgctatg tggaaggcgt caataaatta agaaaacacg gcatacgtgt ctgctcgcat 2556481 attatcaacg ggctgccttt ggaagaccgg gacatgatga tggaaacggc aaaggccgtc 2556541 gcagatttgg atgtccaggg cattaaaatc catctgcttc acctactgaa aggcacgccg 2556601 atggtcaaac aatatgaaaa gggcaagctg gaatttcttt ctcaagatga ttatgtgcag 2556661 ctcgtctgcg atcagcttga gatcattccg cctgaaatga tcgtccaccg cattacaggt 2556721 gacggaccga ttgagttgat gatcgggcca atgtggagcg tcaacaaatg ggaagtgctt 2556781 ggcgccatta ataaagagct agaaaatcga ggcagctatc aaggaaagtt ctttcaacgg 2556841 cttgaggagg aatcagcgct atgattttga agaaaattct tccttacagc aaagaactgc 2556901 tgaaaatggc cgcgggagag ggagatattg tcgtagatgc gacaatgggc aacggacatg 2556961 atacacagtt tttagcggag cttgtcggtg aaaacggcca tgtatacgca ttcgacatcc 2557021 aagaatcagc cgtggccaat acaaaggaac ggctcggtga catgtatcaa gcgcgaacaa 2557081 cgttatttca caaaagccat gataaaatcg ctgaatccct cccgcctgaa acacatggca 2557141 aagtggcggc cgcggtattt aacctcggct atttgccggg cggggacaaa tcaattacga 2557201 caaacggcag ttctacgatc aaagccattg aacagcttct cagcatcatg aaagacgaag 2557261 gtctgattgt tctcgtcgtc tatcatggcc acccggaagg caaagctgaa aaaaacgacg 2557321 tgctcgagtt ttgccgggac ttggaccagc aaacagcccg tgtattaaca tacgggttta 2557381 tcaatcagca aaatgacccg ccatttattg tcgccatcga aaaaaaagct cagatcagca 2557441 aatgatttga gcttttttct ttgaattttt catccaggac attttttgaa atttccggta 2557501 ggctctgccg ttgatataaa agaaaaggga ggtttttccg ctggctttga tcagcttctt 2557561 tgcgagccgg acctgcttcg tcttacttta ccatttttca aattatattt gaaagcaata 2557621 accatcgtta acccggacgt catacagttc gggtttcgat ttttccataa aacgttcaca 2557681 tatagcatga aacgtatgac ttttatctta tcacaaaact ataaacagcc tctgcaaaaa 2557741 cacataccta ttctttcctg ttctctattt tctatgagca cacacaaaaa gagcccactg 2557801 ggagctcttt ttgtcagctg atatttcgtt cgctggcagc agccgcattt tttttatgaa 2557861 acccttttcc atagtacaca gccagcaaga tgagaaacca tatcggcccg ataatcacgg 2557921 ctactcttgt atcagggctg taagccataa gaatgacgac gaatgctaga aatgccaatg 2557981 acacataaga cgtaaacgga aataaaggca ttttgtactt taattgtttc ttttcttccg 2558041 gcttcaaact tttcctgtat tttatttgag aaagcaaaat gattgcccac gtccaaatcg 2558101 ctccgaacgt cgcaatactt gtaacccaag taaatacctt cgcagggaca acatagttta 2558161 acagcactcc gactaataaa gcgcccgctg aagccagaac agctttaccc gggatgccgc 2558221 ctttcgtcag ctgaccatat gcttgtggcg cctctttctg ttccgccaag ttaaacagca 2558281 tccgccctgt gctgaaaata ccactgttgc atgaagacag cgcggctgtc aacacgacaa 2558341 agttaatgat acctgcggcc gatggaatgc ccactttttg aaatgtgaga acaaatggac 2558401 ttccttgaga gccaatttcc tgccacggat aaatagacat aatgacaaat aaagcgccta 2558461 cataaaaaat caaaatccgc caaaatactg tatcgattgc tttggctaac gatttttgcg 2558521 ggttttttac ttcgccagcc gtcaccccga tcatttcaat ccctaaatag gcgaacatga 2558581 ccatttgaag agacaataaa acccctttta atccatgagg gaaaaatcct ccgttgttcc 2558641 acaaattgct gattccggtt gcaatgcccc cattgccgac tcctgcaata atcatcaata 2558701 aaccgacagc aatcatggat aagattgcaa caattttaat caatgcgaac caaaattcca 2558761 gctcgccgta agctttgaca gccaggaaat taacacccgt cataatgacc agtgccgata 2558821 acgcccaaat ccagtttggc acgtccggaa accagaaccc catatagatg ccgacagcag 2558881 tgatttcggc catacaggtg acaacccata aaaaccagta gttccaacct gttaaatagc 2558941 ctgcaagcgg tcccaaataa tcacgcgcat acctgctgaa ggagcctgcg accggttttt 2559001 gaatggccat ttccccaagc gctctcataa taaaaaacat gaccaggccg cttgcggcat 2559061 acgctaccaa aataccaggc cctgctaatt gaatagctga tgcggagccg aggaacaacc 2559121 ctactcctat agcagctcct aaagacatta aagaaatatg cctttcttcg agtccgcggt 2559181 gcagctcttg tttttgtttt tgcatgcttc ttctccccta gaaaaaaata tcattatatc 2559241 atttttctga atattccgta cggattgggt aaatcaatga tgatggagaa ataaaaggat 2559301 aacaacaagg ctttcgacta ctcgaaagcc ttgttgtctg ttacacaaag atgacttctt 2559361 taggctgatg gctcagctct tcaggcatat accgtttttc aatattgatg ctgtgccaga 2559421 tcataaagat tagcacagtc caaattttac ggctgttatc agccttgtcc gcacaatggt 2559481 cttcaagaag ctgaaggaca taatccttat ggatataagc atccgtttgg ctttcttgaa 2559541 taatattccg cacccattcg ttcatttcgt ttttcagcca atgacggatc ggtacaggga 2559601 aaccaagctt tttgcggttt aatacgtgct caggcacaat tccttcagcg gctttgcgaa 2559661 gaagatactt cgtcgtgccg ttcttcgttt tcagctcatc aggaattttt gaagcgacgt 2559721 cgaatacgac tttatccaag aacggcacac gcagttccaa agaattcgcc atcgtcattt 2559781 tatccgcctt taacaaaatg tcgccgcgca tccaagtgtg gatatcgaca tactgcattt 2559841 tgttgatatc gctgtacgag ctgctttctg taaagtaagt cttcgtcaca tcgcgatatg 2559901 aaaggttcgg attataatgc ttcaacagct gctttttgac agactcttca aagattttcg 2559961 cgttaccgat ataacgatcc tgaagcggag tgcagccgcg ctcaagcagg ctcttccctc 2560021 tcataccttc aggcataacg gcagcaacgt gcagaagcat ctttttcaag ccggacggaa 2560081 tccgttcaaa cggtttaagc gaaagcggtt cacggtaaat gttatatccg ccgaagagct 2560141 catccgctcc ttcacctgat aaagcaaccg taacatgttt ttttgcttct tttgcaacaa 2560201 agtacaacgg aatcgctgcc ggatcagcaa gcgggtcatc aaaatgccat acgatcttcg 2560261 gaagctcatt catgtattcc tcaggcgaaa tgactttgct gatattttca atgcccagcg 2560321 ccgctgccgt ttctttcgct acatcaacct cactgaagcc ctgctgttca aagccgacag 2560381 agaatgtttt taagcttgga tgaaattcct tcgcaacaga cacaataaag gaagaatcaa 2560441 tcccgccaga caggaacgaa ccgacaggaa cgtcacttct catatgaacg tttacagagt 2560501 catagatcgc gtctcggact tctttcacaa gcttgtcttc ttcagtctga accggcttga 2560561 agttcgcttt gaaatacgtt ttgaatgtga tatcgccgtc cgggcggatt gtgaattgtg 2560621 aacccggctc tacttttttc acatgggcat caagcgtgct tggttcagga acaaattgga 2560681 aagacatgta ctgctgcaat gcctctttat ctatttcaat atcattctga gcaaccatta 2560741 aactttttct ctctgaggca aaataaacct gatcattgat cgttgtgtag tacaacggtt 2560801 taatgccgaa tggatctctt gccccataaa gcacatgatc gtttttattc caaatcagaa 2560861 aggcaaacat accgcgcagt ttggacgccg cttcttcttt atagtgacgg taagtcgcaa 2560921 gaagaacctc tgtgtccgaa tccgtgttga atgtgtaccc ctttgcttca agttcttctc 2560981 tcagttcgat atagttatag atttctccgt taaagataat ccaatatgtt tcatcttcat 2561041 atgataaagg ctgtccacca ttttctacat caataatgct gagccgtctg aatccgaagc 2561101 cgacgtgctc atcatggaaa tatccatcac tgtcaggacc gcggtgaacg atcatttggt 2561161 tcatttgttt gattagttct tcttgatcag cggtttgagc taacggatgc ttgttaaaaa 2561221 ccccgacaaa tccacacata gtattgcctc cataattaaa attgtcatca ttgaacccct 2561281 atttatagac gctgtgaata gtatttggtt tcacagttat gtaaaaaaat aaacatgaat 2561341 acaacgataa aaaagggaaa gccgcttaac cagtaagcgg ctataaaatt attctcctaa 2561401 cgcttcttta cgcagctgct ccgctttgtc tgtgcgctcc catggaaggt caacatcgtg 2561461 acgtccaaag tggccgtacg cagcagtttg tttatagatc ggacggcgca aatcaagcat 2561521 tttgataatg ccggcaggtc gtaaatcaaa gttattgcga acaacttcaa tcagtttttc 2561581 ctcagaagct tttcctgaac cgaatgtgtt gattgagatt gacacaggct gtgcaacacc 2561641 gatcgcgtaa gcaagctgta cttcgcaaga atcagcaagc tcagccgcaa cgatgttttt 2561701 cgcaacgtat cttgccgcat aagctgcaga acggtctacc ttcgtcgcgt ccttacctga 2561761 gaacgcgcct ccgccgtggc gtgcatagcc gccgtacgta tcaacgatga ttttgcgtcc 2561821 tgtaagtccc gcatcccctt gagggcctcc gattacgaaa cgtcctgtag ggttgatgaa 2561881 atattttgtt tcttcatcaa tcagctcttc aggaacaacc ggattgatta catgttcttt 2561941 aatgttgcgc tgaatttgct caagtgtaat ttcagggtga tgctgagttg aaataacaat 2562001 cgcgtcaatg cggactggtt tgttattttc atcgtactca accgttacct gtgttttgcc 2562061 gtcagggcga aggtacggaa gaatatcttc tttacggact tcacttaggc ggcgggctaa 2562121 tttatgggca agtgaaattg gaagaggcat aagctctttc gtttcgttgc acgcataacc 2562181 gaacattaat ccttggtcac ccgcaccaat cgcttcaatt tcttcgtcgc tcattgtgcc 2562241 ttcacgggct tcaagcgctt ggtctacgcc catcgcgata tcagcagact gctcatcaat 2562301 tgatgttaaa accgcacaag tttccgcatc aaatccgtat tttgcacgtg tgtatccgat 2562361 ttctttaatg gtttggcgaa ccgttttcgg aatgtcaaca tacgtagaag ttgtgatctc 2562421 tccgcttaca agaaccaaac ctgttgtcac agatgtttca caagcaacac gcgcgttagg 2562481 gtctttcttt aaaatttcat ctaaaatgct gtcagaaatc tggtcacaga ttttatccgg 2562541 atgcccctcc gtaacagatt ctgatgtaaa taaacgacga tttttactca tgatttgctt 2562601 cctcctgcac aaggcctccc gaaagacctt gtatatatga tacggaactc gctccctctt 2562661 atacaatgta cagttatatt agagaatgtt aattggcata tttatgaaat aaaaaaacct 2562721 tttccatcga ggaaagggtt tggtctttgt gcctttcact cttatcgctc aaggaatcat 2562781 acaaccttgc aacaggttag caccttggtt gtctcactca gttgaacata ataaataaca 2562841 gagaaaccgg ttgctgggct tcatagggcc tgtccctccg ccagctcggg ataagagtat 2562901 ccgctcaatg aaatatctta tcgtaaaagg gtttgcaatg tcaatatgat tcagaagaaa 2562961 taggcaccta tattgaggga aaacaatgga aatgcacaca caaaaaacaa taaatagtat 2563021 agactatttg aaaatatatg ttatactaat tcacaattag caaaacacaa aaaacgataa 2563081 aggaaggttt catatgaact cagttgattt gaccgctgat ttacaagcct tattaacatg 2563141 tccaaatgtg cgtcataatt tatcagcagc acagctaaca gaaaaagtcc tctcccgaaa 2563201 cgaaggcatt ttaacatcca caggtgctgt tcgcgcgaca acaggcgctt acacaggacg 2563261 ctcacctaaa gataaattca tcgtggagga agaaagcacg aaaaataaga tcgattgggg 2563321 cccggtgaat cagccgattt cagaagaagc gtttgagcgg ctgtacacga aagttgtcag 2563381 ctatttaaag gagcgagatg aactgtttgt tttcgaagga tttgccggag cagacgagaa 2563441 atacaggctg ccgatcactg tcgtaaatga gttcgcatgg cacaatttat ttgcgcggca 2563501 gctgtttatc cgtccggaag gaaatgataa gaaaacagtt gagcagccgt tcaccattct 2563561 ttctgctccg catttcaaag cggatccaaa aacagacggc actcattccg aaacgtttat 2563621 tattgtctct ttcgaaaagc ggacaatttt aatcggcgga actgagtatg ccggtgaaat 2563681 gaagaagtcc attttctcca ttatgaattt cctgctgcct gaaagagata ttttatctat 2563741 gcactgctcc gccaatgtcg gtgaaaaagg cgatgtcgcc cttttcttcg gactgtcagg 2563801 aacaggaaag accaccctgt cggcagatgc tgaccgcaag ctgatcggtg acgatgaaca 2563861 tggctggtct gatacaggcg tctttaatat tgaaggcgga tgctacgcta agtgtattca 2563921 tttaagcgag gaaaaggagc cgcaaatctt taacgcgatc cgcttcgggt ctgttctcga 2563981 aaatgtcgtt gtggatgaag atacacgcga agccaattat gatgattcct tctatactga 2564041 aaacacgcgg gcagcttacc cgattcatat gattaataac atcgtgactc caagcatggc 2564101 cggccatccg tcagccattg tatttttgac ggctgatgcc ttcggagtcc tgccgccgat 2564161 cagcaaacta acgaaggagc aggcgatgta ccattttttg agcggttaca cgagtaagct 2564221 tgccggaacc gaacgtggtg tcacgtctcc tgaaacgacg ttttctacat gcttcggctc 2564281 accgttcctg ccgcttcctg ctcacgtcta tgctgaaatg ctcggcaaaa agatcgatga 2564341 acacggcgca gacgttttct tagtcaatac cggatggacc gggggcggct acggcacagg 2564401 cgaacgaatg aagctttctt acactagagc aatggtcaaa gcagcgattg aaggcaaatt 2564461 agaggatgct gaaatgataa ctgacgatat tttcggcctg cacattccgg cccatgttcc 2564521 tggcgttcct gatcatatcc ttcagcctga aaacacgtgg accaacaagg aagaatacaa 2564581 agaaaaagca gtctaccttg caaatgaatt caaagagaac tttaaaaagt tcgcacatac 2564641 cgatgccatc gcccaggcag gcggccctct cgtataaaaa acaaaagcca agagcaatta 2564701 tgctcttggc ttgttttaat tgacggaatg caaagaagtc agcttgtatg taatgatggt 2564761 ccggccttct tcccattgaa gcttctgcac ttcagctgtg cctgactttt cgccaaactt 2564821 tgttttgcgt acatccattg gaatctccat cggatatact cggtatccgt ccttctctaa 2564881 cgtgaatata ttttcatcta tgcgaacttc ttttcctttt gtcacaatca gtgtattaaa 2564941 ttcaacaggc attcccaaag tgaaatcccc tttcgttctc ttttttcttt atcataacat 2565001 atttcactgt cagcggtttt tcatccattg tgtgagctgc cgcacgatac gccggttttc 2565061 ttttggcggg aaataatgtg tgaatgtact gtagtaccat gtttccaccg gcttatgcag 2565121 ttgttttagc ttctcttcta ataaatagga atgctgaatc gaaacatttt ggtctttttc 2565181 tccatggatt aacagcacgg gagcctgaat tttgtttact tggtcaaacg gtgtcctcca 2565241 ttgatattcc tcaggcacct ttttcggtgt tccgccgatg actcttttca tcattcgccg 2565301 caaatcctgc cgctcctcgt atgtaagaat catatcactg acgcctcccc aggaaacaaa 2565361 tgaagctgcc tgcccgccca tttcgatcgc agtgagcatt cccataattc cgccgcggga 2565421 aaaaccgaag atatggattc tatccttctt gacatttggg tgctgctgaa gcaggcgaaa 2565481 agcagaaaat gcatcctccc tgtcttctcc ggcaaaatcc tcattgcctt ctcctccttg 2565541 attgcctctg taaaaaggag caaacaccac aaacccttgg gatgcaaact ggataatccg 2565601 gcccggccga accatgccca cgcttttaat cccgccgcgc aaatataaaa atccgtcata 2565661 ttgtcccggt tccgccggct cagccagaag ccccttaacc cgtaatccat ttgacagata 2565721 gcagatcgta tacaaacgca catgctggct tggcgacgga aatcttcttt tctctacaat 2565781 caaaacagcc gcctcctttt ttctatatgc tttccttact ccaaaattac atccggagaa 2565841 cctggttagg cattcacaca tttttatacc catcatacga tatgtaaagc aaaaaaggat 2565901 attaacttga tgcgaaataa ggaggttgtc tatgtgaaca gatggttaag gctgggcttc 2565961 gcctgtgtcg gcagtatctt tctgatgttc gccctggcgg cttgcaagca ggaagaaacg 2566021 ctcaccaaag tcaaagtagc tgaagtgacc cattcaattt tttacgcacc tttatatgtt 2566081 gctgagtcta aaggtttttt taaggaagaa gggcttgatg tcgatgtgaa tacgacctgg 2566141 ggcggagata aaacgatgac atcgcttctt tccaacggct ccgacatcgc gcttgtcggg 2566201 tcagaaacat ctatttatgt cgaagcgcaa ggggctaaag atcccgtcat taatttcgcc 2566261 cagctgactc agacagacgg aacgtttctt gtcgcgagag aagatgttga acacttcgac 2566321 tgggatcagc tgaaaggaaa aacgtttctc ggtcagcgaa aaggcggcat gccgcaaatg 2566381 gtcggcgagt atgtactgaa caaacataag attgacccgc ataaggatat agacctcatc 2566441 cagaacatag acttcgccaa tattgccaat gcgtttgctt ctggaaccgg tgagtatgta 2566501 cagctctttg aaccgcaggc ttctctcttt gagaaaaaag gcatcggcca tatcgtggct 2566561 tcattcggag aagaatcagg agaggttcct tatacgactt ttatggcgaa acaaagctat 2566621 ttgaagaaaa atgaagacac agccgtcaag tttacaaaag ccatttataa ggcgcagcag 2566681 tgggttgaaa atcattctgc gaaggacatc acagatgcca ttaaagatga atttgatgat 2566741 accgacccag acgtcatcga aacatccatt gaacgctata aaaaacagca ttcatattca 2566801 ccagaccctc tgcttaacga aaaagaatgg gagcttctcc aaaccattat ggataaatcg 2566861 ggagaactgc cgaagcacat tccatacaat cagcttgtaa ataaagaaat tgctgaaaaa 2566921 gtcacctcgg agaaatagga ggcgccatct atgtctttct tacatgtcga ccatgtaacc 2566981 catacttatt tttctattaa agaaaaaaca acggctgtgc gggatattca tttcgatgcc 2567041 gaaaaaggcg atttcatctc atttctcggc ccaagcggct gcggaaaaac aacattgctt 2567101 tccattattg ccggtttgat tgagccatca gaaggcagag ttctgattga aggccgtgag 2567161 ccgaatcaaa aagaacataa tattggctat atgcttcagc aggattactt atttccctgg 2567221 aaatctatcg aggaaaatgt gcttctcggt ttaaaaatcg ccgacacgct gacagaagaa 2567281 agcaaagccg ctgcactcgg tctattgccg gagttcggcc tcatagatgt ggagaaaaaa 2567341 tatccgaaag aactgtcagg cgggatgcgc cagcgggctg cgcttgcaag aacacttgcg 2567401 cctaacccta gtctgctttt gctggatgag ccattttccg cgcttgattt tcagacaaag 2567461 ctgtctttgg aaaacctggt attccgcaca ttaaaggaat atcaaaaaac agcagtgctt 2567521 gtcactcatg atatagggga agcgatagcg atgagcgata cgatcttttt attttcaaat 2567581 cagccgggca ccatccatca gatttttacc attcctaagg aattggccgc gatgttgcct 2567641 tttgacgccc gtcaggaacc ttccttccag acactgtttc aaacgatatg gaaggagctg 2567701 aattctcttg agaaacagca aagaaaccat tgatctgctt cacgagcagt atcaattcaa 2567761 acagaaaaag gaaaagtgga aggtccattc ctttcagctt gccatattta ttctcttttt 2567821 ctcgggctgg gaaatctcca gcaggcaggg ctggatcgat ccgctgatct tcagctctcc 2567881 atcagctgtg tggcgattat tgctggagaa acttggtgac ggttctttac tgtcacacat 2567941 cggcgtcact ttatttgaaa cggtgcttgg ctttttgctc gggacgttta tgggcacgtg 2568001 cctagccgct ttgttatggt ggtctaaccg acttgccaga attttagatc cgtatcttgt 2568061 gattttgaac gcaatgccga aagtggccct gggcccgatc ctgattgtcg cgctcggtcc 2568121 cagttttatc agcatcattg cgatgggagc catcatcagc gtcattatca caaccatcgt 2568181 tgtctacacc gccttccaag aggtcgacga aaactatacg aaagtcatga aaacattcgg 2568241 cgcaaaaaag tgggttattt ttaaagaagt catactgcct gcatcctccc ccgcgattat 2568301 ttcaacacta aaagtgaacg tcggtttatc atgggttggc gttattgtag gggaattcct 2568361 cgtttcgaag gtcggattag gatatatgat tatttacgga ttccaagtct tcaattttac 2568421 actcgtcttc ttaagcctgc tgatcatcgc catcttcgcc actctgatgt atcagggcgt 2568481 cgagctgctg gaaaagaaat ggacgaaggg gaggacataa aaaacccggc acatgtgccg 2568541 ggttttttat tcaatccatc cagattcttt cagttttttc aagctgatcg gaagaacgga 2568601 atccttcata ataaagctga attttttatt gcgggaaagg ttctccggca gctcgtgaaa 2568661 caaaaccggg cctttcgttt caaagtaatc agcctgcttt tcaagctttt ctatatctgc 2568721 aaaatatata ttttttacaa tcactttttc ttttccgaga actttatact gtccgagata 2568781 cttgaggctt ttgactctcg cgcccgtctc ttcctttact tcccggagcg cagcctcttc 2568841 tgcgcactcc atcggctcta ctttcccgcc tggaaactca tagcctctgt cctcatgttc 2568901 tgttaaaagc catttgccgc caaaacggca aatcacccag acatgcttcg ggctgtccga 2568961 gaaaggctga tcgtcaaagg aaagctgaac agtattctga taataatctt taaactcgta 2569021 catgtttatc cctcaaatcc gttcctagct atcttccata catcatacca cagttacgtt 2569081 tcttcggaag ccttttatca aaaaataagg gaaacccagc acgccgtcag gttctgcatg 2569141 cagactagct cgtacagttt ttttgcgata cttttgccgg aaagtgcgac cgacgctctg 2569201 ggctttatta tgacccgcga acagggaaaa gttacggttt gcgcttaaat ttatttttta 2569261 acgtttctaa aagatcgaca agcatctgag gaaccggtat gccaagagag ctggctgtca 2569321 caacaatttg cacagattca taaagaatat aaaacataat agccaagtca cgaattgatc 2569381 cctgtgtatt cagcagctga tcaaaaaagt ggcatacaga gatcagagcc agcgtgacta 2569441 attttttgac aagccgggca aatacctttt taaatgacag tttgtgaata atggtttcct 2569501 tcaaagtcgt actgataaat tcaattgcca taagagagag caaaatcaga aatgaatact 2569561 gaaaacctcc aaagaaaaaa cccgctgctg aaacgctgac tgctaaaaac gaaaagatgc 2569621 caaagtctct atccatttat cccaacatcc tttcacagaa acggccttac gatattctat 2569681 ggtaaacaag ccgaacggat tggatttttc agaaaaatgg actggttgtc gcctattttt 2569741 cagatacaaa aagaaaagcc ggacgtcttt tttaagacat ccggccgttc tatttttgaa 2569801 cttaacctag gtaagctttt agcatccagt tatgtttttc aatattttga tggatcgcaa 2569861 gaagcatgtc ccctgttgtt tcgtcaccga cttcatcagc taaatccatg ccgtttttca 2569921 gctcttccgc gatgactgtg aaatcatcat atacgctttg aaccatttgt tcagctgttt 2569981 catttccagc agcttctttg acagaagccg tttctaagga ttccttcatt gttgcaatcg 2570041 gttttccgtt cagcgccaaa agacgttctg ctaagtcatc aatataagtt gctgtttcgt 2570101 tgtacagctc ctcaaacttt tcatgaagag tgaagaaatc tttccctttc acataccagt 2570161 gataattatg tagtttcaca tacatgaccg tccagttggc tacttgtttg ttcactgctt 2570221 gaatcaattg ttctgacatg gtatctcctc cttgttatat gactatgtat acccttaata 2570281 tcgtacgcta aaacctcttt tttaccctta tctgtcacga tttcttctat tatgctacaa 2570341 ttgttaaaaa acgggaggtg gaatgtcatg acgcttctca ttacgataag tattttgatt 2570401 gtgctggctg ttttgcttgt aaccatttgg acgactgtaa aagcctataa tgtaaagcat 2570461 accattgatc caccacaaga aaatcactct gattcacaca atcaatgatg atgtgaatgc 2570521 tcctcttctg actgattgct ggcagcatcg gcgtctccga cttggacttt taaggtcggc 2570581 atgctatgct gtttttttgc tgtgacatga gattggacag tgtatacacc atcttcctta 2570641 aacgtcgttt ccaatcggta tacgcctttt tcttgtttca ccttaaacat ttggcttgcg 2570701 tctttttccc cttctttcca tacttcaaac tctacttcat cggcatccgt cacagcttca 2570761 tcaccatatg atacagctgc ttcataagca gcgctttctc cgggatttac tttttcaggc 2570821 ccggtcagct tgacatccaa aacctcgggc gtctcagctg tatttgcttt actttcacca 2570881 gatccgcatc cattaagcaa taaagcagaa aaaagcagaa caaccaacat ctttttcatg 2570941 ccatcaccct ttcatcgttt acctaaatag tagcaaacgc ttacagcaaa tggtacacaa 2571001 aatatgagac gtcacaaaaa agaccttttt gcttaagcgc aaaaaggtcc tttctatttt 2571061 agccaaatac ttttagcaat tcttctttat cctgtgaaag ccagaaacgc attaaacgtt 2571121 tagcgccttc cagatcatga agcttcgctt ggccgcactg cttttcattc gcagcaggta 2571181 tttctgtaat ctctaccgct tccttcattg tgtcttcaag cagatcaacg atttccgctg 2571241 atgtcggctc tccgctcaca actagataat agcctgtctg gcagcccatt ggagaaatat 2571301 caatgatatc aaaatgatcg tatttctcag cgtgagaacg aatcgtaaac gcgagcaaat 2571361 gctcgagtgt gtgaatggtg tcaggcttca tcgcctgttt atttggctgg caaaaacgaa 2571421 tgtcaaattt atttacaacg ccgtctgttc ccactttatg cacgccgcaa tgtcttacat 2571481 atggagcaac aaccgcatta tgatcaagct caaaactttc tactgaaggc ataatggcac 2571541 tctccccttt tttaaaaatg taatttcatt ataacatact tttccgataa gaattattga 2571601 ttaacttttc aatctgtgtt ttttttctta tacttgcatc agaaaggttg ctgaagaaac 2571661 atgaaaaccc tattcatcgc tctgatcaga ggatatcaaa aattcatctc gcccctgaca 2571721 ccgccaacgt gccgctttta tccgacctgt tcccaatatg gaatcgaagc gattaaaaca 2571781 catggcgctt taaaaggcgg atggctgaca atcaaacgga ttttgaaatg ccacccgttc 2571841 catccgggag gagtcgatcc cgttcctgaa aagaaacaaa aacattaatt gttataaccg 2571901 tttacgataa gatccagttt tccggtttta ggatcaatga ctaagccatg gaccggaacg 2571961 ttttcaggga acagcgggtg atgtttaata acatctacgc tgtctttcac actcgcttcc 2572021 actgaatcaa agcttttaaa ccattgatca aagtctacac cggagtactt tattgtttcg 2572081 atgcgttctt ccggaatccc tcttgctttg attttttcaa gcatgctttt gctgctgatt 2572141 ttgctcatgc cgcaatcgtg atgcccgatc acacacacct catctgcatt cagctcgtac 2572201 actgcgacga gtatacttct catgatgctt ccgaatgggt gtgtcacaag cgcaccggca 2572261 cttttaatga ttttcacatc accgtttcgc aaattcatcg catgcggcag cagttcaacc 2572321 agacgagtat ccatgcaaga aagaatcgcc atttttttat ctggaaattt tgatgtttga 2572381 tacttttcat actctctttg ttcagtaaat gtcttgttaa attcgagaat atcatttaga 2572441 agactcatgt tcgttgtccc tttctattct ttttactctt caatatatca caacccttgt 2572501 ttattcgtca taataaaaaa agacaaaccc tcaggcctgc cttatttccc catgttatag 2572561 cgttttttga actgctcaac tcgtccgcct ttttcattga atttctggcg gcctgtataa 2572621 aacggatgcg tgtcagagct tacctctact ttaatgacag gatatgtgtt tccgtcctcc 2572681 cactctgctg tttcattaga tgttttcgta gaggtgctta gaaaacggta gccgctgttg 2572741 acatcctgaa atatcacttt gtggttcttt ggatgaattc cttctttcat gggtatctcc 2572801 tttcaataaa tcgtaataat tacgttttat tttataacct tacaaacgtt ttgtcaatct 2572861 tcttatatcc ttccctctgt ttcacatcgt aaacctcatg gcatttaaga ataggaagaa 2572921 taatctaacc gaggaagcaa ataataaacc caaaatacat acagaacgtc tttttggaaa 2572981 ggtggtttac gattgtggat gatttagttt tggccagaag cctttttggc acgacgatgg 2573041 gctttcatat cattttcgca acacttggag tcggtctgcc gctcatgatt ttagtggcgg 2573101 aattgatcta tcaaaaaacg aaagatgacc attatgcgat catggcgaaa agatggacga 2573161 aagcacaagc cgttttgctg ggggtcgcca taccgaccgg aacgatcgcg ggcactcagc 2573221 tcgcgctttt atggccggga tttatggaag tcatcggccg ggtgatgtcc ctgccatttc 2573281 aaattgaaat ctatgctttt tttgttgaag ccctattcat gtcgatttat gtatacgctg 2573341 cagaccgttt gtcacctgca atgaggattg ttgctgtttt ctttgtgtta gtcggggcag 2573401 cagcatccgc tgttctgatc acgaatgttc acgcttttga aggtacgccc gccggtttta 2573461 aaattttaaa cggaaaaatt acagatgttg acccgtgggc tgcgtttttt aatcctagct 2573521 tttttatcac tgccggccat gtcgtgctgt ccgcgtttat gactggtgcg tttatcgtgg 2573581 cttctgttgc ggcgtataaa atgatccgaa cgaggaaaaa ggaaagggtc tatcgctttc 2573641 accggaaagc ccttttgctc gcactgacga tcggcggtat tttttcattg ctgaccgctt 2573701 tgaacggaca cgaatctgca cagatgctgt acgaatacca gcccgaaaaa ttagccggtg 2573761 cggaaggcct atttgaaaca agatcccacg ccccgctcgc tatcggcggt tttaccgacc 2573821 cgaatgaaga aaaagtaaaa tgggcaatcg agattccatg ggctttaagc tttttggcag 2573881 cgaaccgttt tgacactgtt gtaaaaggat taaatgcatt tccgagagat gaatggccgc 2573941 cgcttttcat tcacacgctg tttaatgcga tggttggtgt aggcatgctg ctaattcttt 2574001 attccattat cggtgtggtc tggagaaagg tgctcaagaa agaccgtttc ccaacgtggc 2574061 ttttgatcat tttcatgaca gcaggccctt ttagtctcat cggcattgaa ttcggctgga 2574121 ttttcgcatg tacggggagg cagccttggg tcatctatca tctgctgaaa acgtcagatg 2574181 tcgtaacaac gactggctcg atcggggtgc tgttcttatt tttcacattt gtttatgccg 2574241 tgttaggcgc agctgtcgtc tacgtgctgc tgtattattt ccgcaagcac ccggttgacg 2574301 aagatttaaa tacagcggag tcgtaatggc tccgcaaaca ggaaaccaaa tggaaggaag 2574361 atcgtacaaa tggagatttc aactgacgct ctgatcgcca tctcaattat ctggggcttt 2574421 gtgtttattt acgccgtcat ggcgacaatg gattttggag cgggattttg gtctatgatc 2574481 tatttaaaca aggagcatat gaaggccacc gatattgcga atcgcttttt gtccccgact 2574541 tgggaggtca caaacgtctt tattgtggcc atcgtcgtgg cgcttttcag ttttttcccc 2574601 ggcgcgacat ttgtgctcgg caccgtttta ttaattcccg gaagcatgat tttgctgctt 2574661 ttagcaattc gaagcggatt tctcgtgttt tcaaatacag caaaggagcg gaaaacgcta 2574721 agatatattt ccggcatctc cggctttatc attcctgcta ttttaatttt ggtgcttcct 2574781 gtgacacacg gagggtttat agaaaaaacg gatggaatct ataacttaaa tatgtctaaa 2574841 atcttttcaa gccccaacgc ctattcattt atcgggtttg cgattttaag caccttattt 2574901 ttgtcctcgc tgttgcttgc agatttttca aatgtggcag aggaacagga tgcgtaccga 2574961 gcctacagaa aaagcgccct gattaccggc ccgatttcac tgttgtttgc tgtatgcatt 2575021 atggtaacta tgcggaatga agcaaactgg ctgtacagcg gaatgatgaa tgatttttct 2575081 tggattattg catcgttcat tacatttgtc attgctggaa tcgctctttt tctgcctaac 2575141 aaaagctttg gtcaaaacat cggaaaaccg cgtctcgcac ttgttgcgat tgggatacag 2575201 tattttctcg caagctacgc gtacgggcgg gcgcatcttc cgtatatgat ttatcccgat 2575261 gtgacagtca tgtcaggctt cacagagcca gcaacgttca gagcgctgtt tgcaacgtat 2575321 atcgttgcat ttatcattct atttccgggc ttctttttct tctggaaaat gtttatgcga 2575381 gataaacgct atatccgcca ggaggaatag agggcaagcc agccggctat actaatccag 2575441 aacctttata aggaggggat ggcatggagc agaaaattct atgtgaggtc aacaactgtt 2575501 cttattgggg caaaggtaac aaatgcaccg ctgatgccat ttatgttgtc agccatactg 2575561 gtgaaacggc tgaaaacagc cgggaaacag actgcaaaac gtttaagccg catgatttat 2575621 aattaaaaga aagagctgca tcagccagct ctttcttttt gcatgttgag tgttctcagc 2575681 tttttagtta tgaccccgtt tgcaggtgaa aacaaaaagg cgcttgcata acatacacct 2575741 gtcatggccg ccatcgctcc tgaaatcgaa acattaagcc acgttgcgaa gaaatagccc 2575801 atgaccgccg acagcccgcc aatcaacgcg ctgagaatca gcatataaag aagccggtct 2575861 gtcagcaaat gtgccgcagc cggcggaaca atcagcatgg ccacaaccaa tacggcaccc 2575921 accgaatcaa aggaagcaac agtcgtcaag gacagcatgc ccatttgcac gtaatgaatg 2575981 agcaaaaccg gtattcccaa ggctaaagcc atttgaggat caaacgaagc gattttaaac 2576041 tccttatagc acacactgat caacactacg tttaaaacca gaacagatgc cagcatccaa 2576101 aacgctttcg gcccaatatc aaccccgaat accgtcaccg tattccacgg cacaaaagcg 2576161 atttctccca ttaacgagtg ctcaatatcg agatggacat tcgctccata cacagaaagc 2576221 aaaataaccc cgattgcaaa taaggatgta aacacaactc ctatggcagc atctgattga 2576281 acccccttgc tatgaagaag ctgaaccaag aaagccgtta acagaccggt tgcggctgcg 2576341 ccaataaaca tataaatccc atcgagactt cccgtcacta gaaaagcgcc gacaatgcca 2576401 agcaacactg tgtgactgat tgcgtcggcc agcatcgcca tgcttctcag cacaagaaat 2576461 gtgccgatca atccgcagct tacaccgact aatacaccgg tagctataat ccatgcttca 2576521 aaactcattt gcgatctgtc ccttctcggc atcatgagac gcttttcgac gctcaggcat 2576581 ccgtccatac agctttaaga gtgaataaag ccgctctctc gtttctctcg gtaaacggtc 2576641 cgggtcaaag tagtcctgat cggattctat attggcaagt tccatttcat gcatgagata 2576701 cacttcatac atccgctgct tcaaagctgt gtgatagcct ttttctatcc ctttgcttgt 2576761 gatttgccaa atcccatttt cgatacgctc aatgcacctc tcttgttcca agtcatttaa 2576821 tgccttaagg cataatgaag gggataggcg tcttttcttt cttacacttt caacagttac 2576881 acaaagatta ttcttttcat actgttcata aatcgccaaa agcacttgct ccctgcttgt 2576941 tctgcgccgc agcctcatca gccttatggc tttagcagcc aatccccgct taggcgcgca 2577001 aatcattgaa aaaagaaaga gcagcgttgc agataagatc attaatggcc ctgtcgccat 2577061 tcccttcatc gtggtgctaa gcagggttcc ggccactccg ctgaccccgc ctgtaatccc 2577121 ggcaatgatg atcatcccgg ttaatcgttc ggtccaatat ctcgcggtta tggcaggtgt 2577181 aatcagcata gccgccatta atatcacacc aacagtctga agcccaatga cgacagcaca 2577241 gacaatcaga caagccaaaa gcccgtttaa aaaacgcacc gggattccta atccctttgc 2577301 aaacgcgaga tcaaaagtaa tcaatgtaaa ttccttaaag aaaacaatac ataggagcag 2577361 tagaacagcg gatatccctg caataaggat gatatcctgc ctgaccaatg aagcagcctg 2577421 gccgaataaa aaagaatcaa gcccgctttg gcttcccgcc ccctgttgct gaatatatgt 2577481 cagcagaatg atcccgacgc caaaaaacac agaaagaaca atcccgatcg ccgagtcctc 2577541 ctttgttttt gaaagccgag gaatcagctg aatacaaaac gttccgagca gtccggcgag 2577601 cgctgccccc agcaaaaaga aaggcagtga tttttgcccg gtgaacagaa aagcgagaca 2577661 cactcccggc agagctgaat gggccatcgc atcgccgatt aaactttgct ttctcagcag 2577721 cacaaagctg cccaaaacac cgcttgccgt cccgagcaaa agcgtaccgg ccagcaccca 2577781 ctgtgtattc ggatgctgaa gctgcagcca caaactttca aacattgcgc tcactcctta 2577841 tgtccttctg ccagcacttt atcttttaaa aacgtaagcc ttcctccata tgttttttgc 2577901 aggttttcga tcgtaaaaac gttttccgtc ggtccgaaag cgattttcct taaatgaagc 2577961 agtaagatcc aatcgaaata atcctcggcg gtctgcagat catgatggac gacaagcacg 2578021 gtttttcctt tttctttgag ttctgccaac agcgtcataa tcgcgcgctc cgtcgctgca 2578081 tcaacacctg caaacggttc atccataaaa taaatgtcag cgttctggca gagtgcccgg 2578141 gcaagaaaca cccgctgctg ctgtccgcct gacagctggc tgatttgcct tttcgcataa 2578201 tcatgcatcc cgacttttgt taatgcggcc ttcgccatct ccacatccgc tttctttggc 2578261 ctctttaata aaccgattct cccgtatctt cccattagga cgacatcgag cgggcttgtg 2578321 gggaaatccc agtcaaccga gccgcgctgc ggaacatatc cgattctggt ccgctgatcc 2578381 ttatagtctt tgccgtaaat agagatgtct ccggaagctc tgggcacaag accgagaatc 2578441 gttttgatca aggttgattt tcccgcgccg tttgggccga taatgccaat aagttttcct 2578501 tcaggcacct gcagcgaaat gtcctgcagt acaggctttt tatgataagc aaccgtcaca 2578561 ttatcaagct caacagggaa catatcctcc acctcttttc tttatttaag cgctttagta 2578621 atcgtgttga tattgtggcg gaacattcct tcgtatgtgc cttcttttgt gcccttttca 2578681 cccatggcat ccgaataaag ctgaccgccg attgtgactg tatggccttt ttctttagcg 2578741 ccttccacca ctgcattgat tgatttttca gatacactgc tttctacgaa cacagctttt 2578801 atttgttttt ctgtcagaag atcaaccagc tcctgaacat cccttaatcc atagtccgaa 2578861 tctgtgctga gtccctgcag gccttttacc ttaaatccat actcattccc aaagtacgca 2578921 aacgcatcat gagcagtcac aagcacacgg cttttctccg gaatatgtgc gatctcctta 2578981 cgcgaccact tatctaaata ttgcaaatct tctttgtact ctttggcatt tttccgaaag 2579041 gcatctgcgt gctgaggcat tgctttgctg aattgcgctt caatttcatc caccgcatag 2579101 atccataacg gaatgctgaa ccagacgtgg ggatcaaacg tcttgccttc ccccgcggga 2579161 ataagcttat ttttcggaat ggcctcagct actgccgccg attgtttttg ttcgccgatt 2579221 ttttggagga catcctccat tttcccttcc aaatgcaacc cgctgtacag aacaacatcg 2579281 gcagacatta attttttcgt gtcaccttgg gaagctttgt aaaggtgcgg atcaaccccc 2579341 ggtcccatta aagaggtgac ttttacgtgc ttacctccga tgttttctgc tgcatcggca 2579401 atttgagatg ttgtcgctgt cacttgtaat tgctgatcag cgctttttcc ggctgaatcc 2579461 gttccgcatc ccgttaaagc aaaggtcgca aaaagtactg ctgccatcag cccttgtctc 2579521 atatttctcc tcctctttgc catcaatgtc cgattgtttt atcttatgtt gtcagttctt 2579581 agacatgtga cattaaatta gccaaaagca tgttttattt acacaggaca aaaagtttcc 2579641 ctcatgcaaa attatcgcgt ttggccattt ttgtcaagct gatttacata aaaaaaccgg 2579701 ctgggtcagc agccggtcca aacgagaagg gatgtattca acgaacactt ttactgtaac 2579761 agcacagtgt catttattca aaatagcaaa atgctttttt cttaaccatg ctgtgtgaaa 2579821 acatccattt tggtcacata ttttcgcata atatcttggt ttacctcaac ccctaaacca 2579881 ggctgttttg acacagaaat aaatccatta tcaatacgaa tatcaggagt tacaatatct 2579941 tcatcccaat agcgtgagga tgaagatata tcgccaggta ttgtgaattg aggcagtgaa 2580001 gcaagcgcca cgttctgcgc tcttgatatg cctgtttcca gcattcctcc gcaccaaacc 2580061 tgcatatgat gctctttgca taaatcatga atttttaagg cttctgttaa gccgccgaca 2580121 cgagaaggtt ttatattaat aattttgcag cttcctagct caatcgcccg tctcgcatca 2580181 tcaactgaac aaatgctctc atcaaggcaa atggccgttt tcaaatgttt ctgcaagtgg 2580241 cggtggtcaa cgatatcgtc agcttggagc ggctgctcaa tcatcattaa atgatagtca 2580301 tcaagctcct ttaaacggct gatatccttc agttcgtaag aggaattggc atcggccata 2580361 agcgggatgg ttgggaatcg gctgcggatg gccttgacca attccacatc ctgcccaggc 2580421 tgaattttaa tttttattct ttgataacct tctttttgat agctctcaat ttccttcagc 2580481 atatcgtcaa gaggcgccag gccgactacc accccggcag ggactttatc tcttgttccg 2580541 cccaatgcct cagcaaggga tacgcccttc tttttggcat aaatatccca tacagccgat 2580601 tcaagtcccg cttttgccat ccggtttcct ttataccgcg ccaggctgtc cggcacttct 2580661 gaagggtgat tgaattcacg gccgacgaca tttgggataa aaaaatcttt tagcatatgc 2580721 aaacatgttc caatggtttc ctcggtgtac caaggcgaag agaaagcgga aacttctccc 2580781 cagcctgtga cacctgatgt atcaatggct tccacgatca gaaatttacg ctcttgaagc 2580841 gtttcgatac tgtttttaaa cggtttcttt aagttcatgc tcaaatggta aagcgtgatt 2580901 ttttctattt cgatcatagc agttctcctt tacgcgcatc cttcagctga tttcgcaaga 2580961 gcttattaga cgcattgcgc ggcaggcggt caagcacaaa gaattttgcc ggaattttat 2581021 acttcgccaa gcgttctttg cagtagtcag tcaattctcc tgcgctcaca ggcttgtgaa 2581081 ggacaagata ggcgtgaggc actttccccc attttttgtc ctcagcccct gaaaccccgg 2581141 cttcggccac agcggggtgt gaaagcagca ctgactccac ttcggccgga taaatgtttt 2581201 ctccgccgga tatgatcaga tctgaacgtc tgtctaatac atataaaaag ccttcattgt 2581261 ccaaataacc aagatcacct gttttcagcc agccattttg aaaggaggct tcgtttgcgc 2581321 tctcccggtt aaaatagctt ttcatgacat tcgggccttt gaccatgatt tcaccgtgtt 2581381 catacggttc acatacctgt ccgtcccgct ctattttgat ttcacacgaa aacagcggtt 2581441 tccccgcaga tccgagcttt tccatgctga attccggcga cagggtaaca atttgcgagc 2581501 atgtttctgt cattccatat gactgaaaga cagggaatcc tttctcacgg cattcctcaa 2581561 gcaatggcag cggtgcagga ccgccgccga gaagaatgca tctgatggat tcagggcagc 2581621 ggtttgtttc ttccaaaaga ctggccagca tagtctgcac cgcagatatc attgtcactt 2581681 catgcctgtt gatagaatgc agcacatcgc ttacggaaaa acgctggtga agcacgacag 2581741 tcattccata gatcacagat ttaaataatg cggacaatcc gctgatatga aagagcggca 2581801 atgcgataag ccagcggtct tgttctgtta tacccaaatt aagagcggac gacaccgcac 2581861 tgaaataatg gtttccgaac gtttgctgaa ctcccttggg ctttcctgtc gtacccgacg 2581921 tatacatcag cgttgccgtt gcatccattt gcatataagc ctcgatctca atttcctctg 2581981 ctgcttcttt catcagttca tccacatcaa tcgtttgaac gatgtgttca tattctttct 2582041 tctcaaagct tgaatctgtc aataaaaagc cggatcccga atcctccagc tgaaacagcc 2582101 tttcatgtgt tgacagcttc gtattcaaaa gcaccgcctt aacaccaagc aaaaaacaag 2582161 cgtgaacagc gtataccatt tctgcacggt tttggagcaa aatagctgca gtatcccctt 2582221 tccgaaccga atgagcggca agctgttccg ccattcgttt agacgcggca aacaattctg 2582281 caaatgtcac ggtttggtct tcatagatga gagcgattct ctcaggtgtc agctgtgccc 2582341 gctgcatgag ccagttgggc tgttctgtca gcatgtcatc atctccgagg taaaatgtct 2582401 gtattgaaaa gaaaacagct tggaccgcaa agtctcaagc tgttggttta ctagatattg 2582461 ctgatcacgg aaaacgaggg aactgtccga aatcaggttt gcgtttttcc ttaaaggaat 2582521 cacggccttc ttttgcttca tctgttgtgt agtaaagaag ggtagcatcc cctgcaaact 2582581 gctgaattcc agcaagtccg tctgtgtccg cgttaaacgc agctttaaga aagcgcagtg 2582641 cggtcgggct tttttcaagc atttcttcac accatttaat cgtttcttct tcaagctgtt 2582701 ccaaaggaac gactgtgttg acaagaccca tgtccagtgc ttcctgtgcg ttgtactgac 2582761 ggcataggta ccagatttca cgtgcttttt tatgtcctac aattcgagcc aggtagccag 2582821 aaccgtaacc tgcatcgaag cttcccactt tagggcctgt ttgtccaaaa attgcgttgt 2582881 ccgcagcaat tgtcaagtca catacgatgt gaagcacatg gcctccgccg atcgcatatc 2582941 cggacaccat cgcaacaacc ggtttcggga tgacgcggat taaacgctga agatccaata 2583001 cgttaagacg agggatctgg tcgtctccta catatccacc gtggccgcgc actttttggt 2583061 ctccgccaga acaaaatgct ttgtcccctg caccggcaag cacgataacc ccaacgtttt 2583121 ggtcgtctct tgcgtcagca aacgcatcaa tcatttcagc aaccgtttta ggggtaaacg 2583181 cattatgtac ctcaggtcgg ttgattgtta tttttgcaat gccattatac gtttcataca 2583241 atatctcatc gtatgtccgt tttgttttcc attcagccat atgatgacct ccttttattc 2583301 tctatgtgaa tgagtcagat gcttgtcaaa aactcactca ctattttacc aaacaatcgc 2583361 ggctgctcca catggaccgt atgtcctgct tttggaacaa tctctattct actagaagga 2583421 agcatcttat gcacctcttg attgatggcg caaaattttt cgtcccactc cccgcagatc 2583481 agaagcacag gaacatctat ttcctctaca cggctccaca aggaaggctg tgaaccggtg 2583541 cccatgccgg ttaaactgtt cgcaagccca atcttattgt tccgcagacg gcccgatcgt 2583601 atcctgtacc gaatatcttc agccagcctc tgctgagatg aaaacaaagg gatattctcc 2583661 caatacgcaa caaacgcttc gagcccgtct cgtaaaataa aatcagcaag cttccggtcc 2583721 cgcatgattc gttcccgccg ttccccaagt gttttgagcc ccggcgtcgt gctttcaagc 2583781 acaagtgccg atacccgctc gggatatgtc atcgcaaaag agtaagcaag ccttcctccc 2583841 atagaatacc caatcaattt cactttgtga agttttaatt gatcaaaaat ctcggcaagg 2583901 tcagaaactt gccgggttgt gctgtatctt ttcccattca gcggggcatc ggtttcccca 2583961 tgccctaaac aatcaatttt gatcaaacgg gaatcaggca gcatttcatc aagaaaagtc 2584021 catgattgtt tgctgccggt aaacccatgc agacagacga cggcttcgga agcattcggt 2584081 ccctcgtctg ccactgcata tcggacacca tctgataccg ttatgtttac agttcccatt 2584141 gttttttcac ttcccgcaca gcctcattca gcatatcgcg atgaagctgg actcttgatt 2584201 ggcgatccgt tttgatttca atcaaatgga gtccgggctt gtctgcctgc ggcgcgtaag 2584261 ctgttttgaa ttcatcccaa gaagccgggc atgaatacgt tccgccgtaa agtgcagccg 2584321 catgcttgaa atcgagccct gtcggtgtgc cgaacaaatc ttcaaagtgt gtcttctcag 2584381 aagcctgcgg caaaaaggag aaaatccctc ctccgtcatt attgacaaga atcacagtaa 2584441 gaggaatacc cagctttttg gccgccagca ggccgtttaa atcatgataa aaagataaat 2584501 ctccaatcac aagggtaaca ggcgcttttg ttccttcaca tacccccatg gcagaggaga 2584561 cgacaccgtc tatcccgttt gctccccggt ttgaataaat ccggaaaggg cggtcctgct 2584621 tttcaaaaaa cgtatcaaca tccctgatcg gcatgctgtt tcccacaaac agcgagctgt 2584681 tttcaggcac aagatgctga aggattcgat agagattgcc ttcaaacgaa acatcttcac 2584741 tgctgattgt ttgcagatgc tcgcggaacc gcccattgac aaactgccac ttttccagcc 2584801 actctgagga tctggtggca gcagtaaggc ctgccatgat ctcctcagca aaaacagacg 2584861 cattacaatg aatcatatgc gcgcttgcct gtgtcgggtc tctccaccct ccatcctcgt 2584921 caatcacgat ttgctgaatc gtcggatcat ccttaagcca taagaaaacc ggttttgaaa 2584981 caggcatcgg tccaaaccga atgacaacat caggacggag tttccgcttc agctcatcat 2585041 cttttaaaaa cgaatcatac gcatcaataa cagtgctttt atcatgaaca ccattccgca 2585101 gattagacag cggatctgct aaaattggat actgaagcgc ttttgacagc gcaataatgt 2585161 tttccttgtc cgcatcacta tggagctctc cgcagacgat cattcctttt tcagcctctg 2585221 cgagcatctc agccacatca gacagggact ctcggtcaac agactgcgta cccgttttca 2585281 cagacacatg acggcctgtt ctcattcttc caaacggctc atctgaaaga tccggcatca 2585341 gcggttcgcg cagcggcaca ttcacatgga caggccccat cgggcgcttt tgtgcttctc 2585401 cggcagcgcg gcttgccagc gttcggatgt atctcagcat ttgcggagac tcttcaggaa 2585461 gagcagagtc tgtgaaaaac ttaacaaagt taccgaataa gaagtgctga ttaatagcct 2585521 gcggtgcgcc tacttcgcgc agctcatgag gccgatcagc agttaacaca ataataggca 2585581 cccttgaata atgggcttca accacagccg gataaaagtt ggccgcggct gttccagatg 2585641 tacagatcaa tagtacggga cgctgcttcg cttttgccaa acctaatgca aaaaatccgg 2585701 cagacctttc atcaatttgg acatggacgc tgatatcggg atgcgcagca caaagaacag 2585761 ccagcggtgt agatcttgag cccggacaaa cgacggcgtc cgtaattccg gaaagggcga 2585821 attcatcaat aaaacttccg atgtaatgag taatcgggtt gactgtcaac gcctctcacc 2585881 tcctaatgca gagatcatcg gcttcaattt aatctgtgtt tcttcatatt ccgagattgg 2585941 ttccgagtct tccacaatac cgcacccggc aaacagcctt gctgtgcttc cttcgatgag 2586001 ccctgaacga atggcgaccg cgaattcccc gttatcctgg ctgtcaatcc agccgatagg 2586061 ggccgcatac cagccgcggg acatcggttc aatctccctg atcacgtcaa cagctttttc 2586121 ctgaggtgat cccccaagcg cgggagtggg gtgcagcttc tcaattaagt caaaaatcga 2586181 agcagactcg cgcagctgtc cgacaatcgg cgtaaacagg tgctgaacgc tttttgtttt 2586241 gtacaaaaca ggtccatcag gcttttcaac ctctgaacag cttgatacaa aagcattatg 2586301 aatcatacct accacaatat catgctcaag caggtttttc tcatcgttta ataattcaag 2586361 gcctatccgg cggtcgtctt cttcattcac gcctcgttta atggagcctg ccagacagga 2586421 agacatgaca gtgccgccgt ctcttttgat cagtctttcc ggagacgcgc cgacaaaggt 2586481 tttgccttct tgttcaattg caaaaacata gcttgtctgc tgatcgtcca gaagcgtttt 2586541 aagcaccggt tcaatttgga ttggaccgtc aaacgtgagc agcagctctc gggcaagaac 2586601 aaccttatca tattgtttct ctttaatttg gcttgtggcc gtttcgattg ctttcagcca 2586661 atcatcctta tccagctctt cggctgctgc aatcacagcc tgatcttctt gcttgaaatc 2586721 gggaaccata aattccgccg caaaagcttt taagccttct aaaacagctt ctgcgtcttc 2586781 tcctccgctt acccatctgt taactgttaa gaacgggcct tcagcagtca tcgtcagcat 2586841 aagcgcaggc acaaagaaat ccccttccga gaaatggtcc cattgtgaac ctctttcttc 2586901 gcaagggtca aaagaaaatc ctccgaataa cacaggtccc actgcagaat gctgcagctt 2586961 ttcttcttca taaatatgaa aagccgtctt tttaaagcgc tcccattgtt caaaaacctc 2587021 acgataccgc tcgctgtttt tttgatttgt ctggaaaacc gcttctttgc caagaccgac 2587081 tattgtcaat tcactttcag gatctgacca aaaaaatcga ttgcctgtat atttttttgc 2587141 tccgtaattg aaaaatgata gagggtcaag agactcgatt tgtctcgaat agcttattaa 2587201 gacagcatgg ttgacttctt tggctttatg taatgcatgt agaacttcct ttcggaacgt 2587261 acgctgcacc gttgtcacca tgagacattc ctccataatc cttaaaatgc ttttaatacc 2587321 atacacctgt gtctcctttg tgtcaaacac agatcatgca gtccaaatgg cctgccttac 2587381 ctattataaa cctaatttca gaaatgaaaa agaaacaaag cttaaatttc tttctccact 2587441 gatagcaaag gttgtatccg cttaccataa aaggaaaacc tcctatattc ctccacccgc 2587501 catttatgaa agttctcagg cgatctgttc atactaaagg tatgcatcac agagaaacga 2587561 ggcgatcaca ttgcttacga aagaacagct tcagcattta aaaaatgaac tggaacaaac 2587621 gaaaaaagat atcttaaacc gtttcaaaga caatgatcat tttcagctta actcagcctt 2587681 tccttatgat tcgtggggtg agctttcggc atacgacaac catcccggcg atcaggcgac 2587741 agaactttac gagcgtgaga aagacatcgc tctagacttg catgagagag agcaccttcg 2587801 ggacattgag cattcattga aggcgataga aaacggtacg tatggcattt gtgaagtcag 2587861 cggaaaggaa atccctttcg aacgacttga agcgcttccg actgccacaa ccctcgcgga 2587921 gtattcgtca caggacgtgg tttccaaaga ccgtccgatt gaagaagaaa caccattcgg 2587981 gcaatttgaa tttgatgatg atgaagaaat cagagcgcca tatgacagtg aggattccta 2588041 tcaggatgtc gaaaaatatg ggaactcaca aacgccgcag gatatggaaa accctccgct 2588101 cagctatgat gatatgacga tgaatgccga agagaatatc ggcaatacgg agtcttacga 2588161 aaatttcatc gctacagata tcactgggaa agaaattacc gtttatcaaa gcagagccca 2588221 tgagcgctat gaagaagaac ttgacgaaga gggaatcatg accacattcg gcgatctcca 2588281 cgctgattga acccccaatt attgggggtt cttttccgtt ttcagcatat cgtaaatcag 2588341 cttcagataa tccttttgca ggccgatgtc ataccgctcg ccctctagca atttcccgta 2588401 tacggtacat gccccgagcg aagcttttat cgcatccgtt acctgcactt ctcctccgct 2588461 atcagcttct aatgcctcca gctcattaaa aatatccggt gtgaaaatat aacgccctgc 2588521 tgcggcaaaa tgagacggag ggttttgttt aggcttttcc acaatatcct gtatgcgata 2588581 aagccctttt tcaacaggct ccccttttat caccccgtaa tgatgtaaat cctccgtttt 2588641 tgtttctttt aagccgatca cactggactg atatttcgta tacgcttcaa tcagctgccc 2588701 caaagccggc tgattggcgg aaaaaatcag atcatctggc aaaacgacgg caaaaggctc 2588761 tcctcctgca aattgctttc cgaaagaaat ggcgtcgcca agaccctttg cataaggctg 2588821 ccgcacatag tgaatccgta tatccggaat gggatgctct ctaagtaaat gcagtttatt 2588881 cttagaggcc aaaaaagcct caagtgccaa agaggaatca aaatagtcga caatcagatt 2588941 tttatggctc gatacaacca tcaaaatgtc ctcaatgcct gactccttta attcttcaac 2589001 aagataatga atcacaggct tagatcctac cggaaacatt tctttcggaa tcaccttcgt 2589061 caccggcaga tttctcgtgc cgaatccgcc tgcaggaatg atcgcttttt ttatcatggt 2589121 attttcccct cagctcatgt ttattacatg atattccaag agcgcatccc gatgtttgta 2589181 catctgaaat taggcggaag caactgggca gaaagcggaa tcacgaacca gccctttttt 2589241 aataggatat tgatatatga ccagtaatct tgtaaaggag ctcaggtgat gaaaatttgt 2589301 gtggttggcg ccgggtatgt cggtttaacc ctatcagcgg cactggcatc catcggacat 2589361 gacatgatat gcacagacaa agacgtcaaa aaaatcgggc agctgaaaaa aggagtcatt 2589421 cccttttacg agcctgggct ttcagatgca atacttcgtt gcggcaatct ctcgttttct 2589481 tctgaagtga aatcgagcat ggaggaatgt cccgttattt ttatcgcagt cggaactccg 2589541 ccgcgttcgg acggatcagc tgatacgaaa gccctgcagt ccgtcatcgg tgatttaagc 2589601 gaggcgatcc gatcgtataa aaccattatt acgaaaagca ctgttccgcc cgggacaaat 2589661 gaaaacatag caaaacagct gattgcctcc ggagtgtcta aaaacctctt taatatcgta 2589721 tccaatccgg agtttctgcg ggaaggcaat gccttatatg acatgctgca tcctgacaaa 2589781 acagtcatcg gtgttcagga agaagatcac gtatcggcag ccatcgtcaa atccatttac 2589841 aaacacattg ataccccttt tatcgttaca agcttagcgg gagcagagct gatcaaatat 2589901 gccaacaatt tctttttagc ggccaaaatt tcgttcatta acgaaatggc ccgcatatgt 2589961 gaagcctatc aatcagatat ctcagatatt tcccgcgcta tcggtctaga cccaaggatc 2590021 gggaagcact ttttgcaggc aggcatcgga tacggaggct cttgttttcc aaaggatctg 2590081 caggcgctgc aatttgctgc ccaggaaaaa aacacggaga ccttcctgct ccgggccgtg 2590141 cagcacatta atgacaccca gcttggcctg tatatcaaaa aaatacagtc attcttcgaa 2590201 acacttcaag gcaagaaagc ggctgtactc ggcatttcct tcaaaccgaa tactgatgac 2590261 atccggaatt ctcaggctgt cagactgatg gaaaggctgg cggagctggg atgtgatgtt 2590321 catgcatatg atcctgaagc tgtacttcca gaacatttgc ggcaacatgt aactcagcat 2590381 tctcaagctt ttgatgcgat cgaagagagt gactttttat ttttggcgac agaatggtct 2590441 gagtttttag cgtttgattg gaaaaaggct gcagatatca tgaaagggcg tcttgtgatt 2590501 gacggacgca acgtactaaa aaaagaactg atcgaggctt gcggcctgat ctgtacggga 2590561 gttggccgtc catgaaaata ctcgtcacag gagcagcggg ctttatcggc tcccacctct 2590621 gcgaagaatt actaaaagat aagaaacata acgttatcgg aatcgatgac tttatcggtc 2590681 ctactccatt ttccttgaaa ttaaaaaacc ttaaaaacct gctgccggaa aagcgattta 2590741 cgttcataaa ggaaaatctg ctgacagccg atcttgcttc cttactggaa ggagtggacg 2590801 tcatctttca tttggcggcc ataccgggtg tccgctcaag ctggggcaat cattttcacc 2590861 catatgccgc acataatatc caagcgctcc aaaggctcct cgaggcgtgc cgggaacatt 2590921 ctattcaaac gttcgtcttt gcatccacct cttccgtcta tggcgaaaaa caaggaaaag 2590981 tcagcgaaaa cacgtcgctt tctcctttat ctccgtacgg ggtaacaaag cttacgggag 2591041 aaaagctttg ccatgtgtat aaacagagct ttggcattcc aattgtgatt ctccgttttt 2591101 ttaccgtata cgggccaaga cagcggccgg atatggcttt tcaccggctc attaagcagc 2591161 accttcagca aaagccgctt accatcttcg gtgatgggca gcagtcaaga gatttcactt 2591221 atatcagcga ctgtgtcaaa ggcatcaccg ctgttcttgg gaaaccccac cttattggtg 2591281 aaacagtaaa tatcggcggc gcagagcgtg cctcagtctt aaaagttgtc tccctcattg 2591341 aggatatttc cgggagaaaa gcaacactgc acttttcgga caaaatagca ggggaaccga 2591401 gcaacacgtg ggcggatatt tcaaaagcaa aacagctctt gcattatgat cccgccacat 2591461 ccttaaagga tggcttgacc aacgaaatcg cctatttatc gtcgctgtat cagggggaat 2591521 aaaaatgaag cttgccttta tctgtacaga aaagctgccg gcgcccgcag tacgcggcgg 2591581 cgctattcaa atgatgattg acggtgtcac gccctatttc agcagcaggt acgacctgac 2591641 cattttttca atagaagatc catcgctccc aaaaagagaa acaaaagacg gcgtacatta 2591701 tatccatctg ccaaaagaac attaccgcga ggcggtagcc gaagagctgc gagcctcttc 2591761 ctttgacctc attcatgtgt tcaacaggcc tttaaatgtc tctttatata aaaaagcctc 2591821 accaaacagc aagatcgttc tgagcctgca taacgaaatg ttttctgaaa aaaagatgac 2591881 cttcgcgcaa ggaaaagaag tactcgacaa tgtctccatg atcacaacag tgagcgaatt 2591941 tattaaacaa accgtcattg aacgtttccc tgaagccgag gacatcacaa aagttgtgta 2592001 ttccggcgtt gatttaaact cttatccgcc cgtctggacg atgaaaggct cggctgtcag 2592061 aaaaacatac cggaaaaaat acggtattga agataaaaaa gttattttat tcgccggccg 2592121 cttaagcccg acaaaagggc ctcaccttct cattcacagc atgagacgga ttttgcagca 2592181 gcaccctgat gctgtactgg tcatagcagg cgggaagtgg ttcagcgatg acagcgaaaa 2592241 ccaatatgtc acctatctgc gcacgctggc gctgccatac agagaccaca taatctttac 2592301 aaaattcatt cccgcagacg atatcccaaa cctttttctg atggcagatg tatttgtgtg 2592361 cagctctcag tggaacgaac ccctcgcccg tgtgaattat gaagcaatgg cggccggcac 2592421 gcccttaatt accacaaacc ggggcggaaa cggtgaagtc gtaaaacacg aagtcaccgg 2592481 ccttgtcatc gatagctaca acaaaccttc ttcatttgca aaagcaattg acagagcctt 2592541 tacagatcaa gaattaatga acaaaatgac aaaaaacgcc cgaaagcatg tagaagcttt 2592601 atttaccttt acccatgctg ccaaaaggct caatactgtt taccaatccg ttctgacccc 2592661 gaaaaacaaa caatttccgc cgccttttct gacgcaaaat tttgatttat catctatcaa 2592721 tcagcttttt gtgaaagcaa aaacataaaa cctacagctc gtgttgcaaa acgggctgtt 2592781 ttttcgctac agagaactta aaaaaaggca taaatgtgac tttatgcctt gcgctttaca 2592841 gtttgagaaa accatggagc tggtttagat tcacttggaa gaatgatgat ttccacttta 2592901 gcttcttccg ctaagtctgg ttcttcatct tcatcctctt cttcatatgg gggcgctgag 2592961 cgtttcgaat cacgctcctc ctcaggctcc agagtggttt cgaattttgt ttcttcttca 2593021 tcatcgacga ttttgcgatc tgtttccttt tccttcgttt ctttttgata ttctttcggt 2593081 gcattgatgt gagggagctc tcgaatgctg cccacatcta aatgcttctc ctcttcttcc 2593141 ttctcagctg agattgagtc atgagcctgc catcccatcg gtccaggcgg tgtaaatacg 2593201 aattggtcga gatccagttt agaaatagag gctttttgtc tcgatgacct catgtcaatt 2593261 cgcctcccga tacgctttta tctttttata cagttccggc agtttatcca aaaacgaatc 2593321 tttagattct tcaacagaaa tcatgttttg cagcgcccag ttatacttct catctgacca 2593381 cgttttcttt tgcttcaaat aatatttgtg cccgattgca cagaacaaat gcggaaacgc 2593441 gagatcaatc caaagtacct cgtactgttt ttctgtgagc ggatacactg cgtcgtaggc 2593501 cgcaagcagt gcaaccatga aatcagtatc ccatacagaa agcttaacca tcactttatt 2593561 cagcagaata cgaaggtctc ttgacggcaa atcgtaggta atcgagtgaa gctcctttaa 2593621 aaaaggctcc ccttcgatct cagtcaaacg tgccaatgta aaatcctgaa aacagaatcc 2593681 gccatgctcg agtgtctctt ttgtccaggt ttcgtattct gagtcatcaa gcgctctgag 2593741 agcttctttt cctcttgcca gcattttatc agcatgtttt aagaaagttt gcgaaaatac 2593801 gtcatcagga taggatgctg cgatctgcat attcccttca agttcctgca gcttccaacg 2593861 gtacaatttg tgccattttc ccagcctgct tctcttcttg ctttcatctg tgcaaacata 2593921 tccttttgag gcatgatgaa aatggccggc aaatgacatg acttttttca tttgctctgc 2593981 atcatagtaa atcatttctt ttcctgtcac tttgtcatat aaactgtaag aaacctgatc 2594041 cgtgcccaag cagctaccgc cattttttgt ttgatgaatc ggcgctatcg gcagcccttt 2594101 ctcttgtaaa tgggcgtgtg cctgagtgat aaaaagcatc cgctccggtt tcatttgcgc 2594161 ttcttttagc agctttgggc catgatcagt ttcgacttcc cagattttgc gcccgctttt 2594221 gttcgatttc agcgccacat ggtcgatatg aaacggataa taactgagaa tttcggacac 2594281 aatctgttct tcatgctctt tttggtacac tctgttcacc ccttctatct gttcttttca 2594341 tagacgctga gcagattttc agccaccctc tgccagccaa aattgctttc tgcctcacgg 2594401 cggctgtatt tcccaagccg ttcccgcttt tccgagctgc tcagcaaatc attgatacgt 2594461 tcggcatatt gtttaggatt ttcaaagtca tgaatgatgt agccgttttt cccttcctct 2594521 atgacctctg gattgcctcc ccgattgctt gtaataatag gaagtcccgc agccatcgct 2594581 tcataatgca cccttgctaa aggctcctgc cattgcgaag agcatacaaa tacatctgac 2594641 atggtataaa ggcgcggaat gtcctttggc ttcacaaatt gaataaatgt gacatgatcc 2594701 ttttgcatcg caccaagggt atgaagatgt ttgacatagt tatttaattc attatctccg 2594761 aaccattttg acccgataaa caccatcatg acatcggggt gctcctcaat gatgtccggc 2594821 aaagcctgca ataatatgtg cgggcctttg actttgctaa gccggccgac aaacaagacg 2594881 atttttttgc cgtgaagccc cagctcgctt cgcatctctt cgcgagctcg ctgcccttca 2594941 ttcgtccagc gagggtggta cgtttttaaa tccacaccag aatacaccgt ttttgttttt 2595001 gatcgtgctg acggaaaacg gcttgtgatc gtctgtccga tataatcgct gaccgtaaca 2595061 atctgcgcta cggagtcgat gcaaatctcg ccttccgcct ggctgatttt atcgtaagcg 2595121 aacatttcat tgtgaacgct taaaataaaa acagcatccg gcgcctgttt cttcaatttc 2595181 ggaacccagc ttgggcgatt acaaacatgc acaagatcaa aacggctctt tttcagctct 2595241 gctccaacgg cttcttcata acggtcttca tccaaatgca cataatggac accgtctacc 2595301 ttctctctat cagcgagatt cggatcttta atagaaaaca cagtcacctc atgttttttt 2595361 gcaattaaag gggcaaccgc ttcgaggtag atttgaatgg cgcctcctcg aaccgatggg 2595421 acaggaagct tctctgtggc gatcagtgct attttcatac atagcctcca ttcctgcatg 2595481 atttttaact agttagaatc atgatacggc tgaacaacca acttgtgcgg aatgggactg 2595541 ccctaaaaac aaaacgggta aacaaccaga ttcatctatt aaatatagtc aaataactca 2595601 atcatttttt ccttttgatt cataaggtag gagtaaaaca ggtaaggatg tgtcctttaa 2595661 tggcagaaaa ccatgaagtc attgaggagg ggaattcatc agagcttcct ttatcagcag 2595721 aagatgcaaa aaaattaacg gagctggctg aaaatgtgct tcaaggatgg gatgtgcagg 2595781 ctgaaaaaat agacgtcatt cagggaaacc agatggcgct tgtctggaag gtccacacag 2595841 actccggcgc ggtttgtcta aaacgaatac acaggccaga aaagaaagcg ttgttttcca 2595901 ttttcgcgca ggactattta gcaaaaaaag gcatgaatgt tcctggcata ctcccaaaca 2595961 aaaaaggcag cctatattct aagcacggct catttctatt tgtcgtatat gactggatcg 2596021 aaggaagacc gtttgagctg actgtaaagc aggacttgga gtttatcatg aaaggccttg 2596081 ctgattttca tacagcttcc gtcggatatc agccgccaaa tggcgttccc atatttacca 2596141 aattaggtcg ctggccgaat cactacacga aacgatgcaa acagatggaa acgtggaagc 2596201 tgatggcgga ggcggaaaaa gaagatcctt tctcacagct ttatcttcag gagatagatg 2596261 gctttattga agacgggctg cgcatcaaag accggctttt gcaatcgacc tatgttccat 2596321 ggactgaaca gctgaaaaaa agccctaacc tttgccacca ggattacgga accgggaata 2596381 cactcttagg agaaaatgaa cagatttggg tcatcgactt agataccgta tcatttgatc 2596441 tgcctattcg cgatttgcgc aaaatgatta ttccgctttt ggatacgacg ggtgtttggg 2596501 atgacgaaac atttaatgtc atgctgaacg catacgaatc cagagcccca ttaactgaag 2596561 aacaaaaaca agtcatgttt attgatatgc tgtttcctta cgagctttac gatgtcattc 2596621 gcgaaaaata cgtccgcaag tctgctttac cgaaggaaga attagaatca gcttttgaat 2596681 atgaacgcat taaagcaaac gcattgcggc agcttattta agaccatcat ttcccccgca 2596741 tatcgggggt ttgatattta taagataaag ggtaattaaa tacatgcgga ggttgcaaat 2596801 atgaaaaaga ttgtcggcgc tttagccgtt tttgtgatta catatgcgct gttttcagcc 2596861 gcaggctacc tgtttcctgt ggaccaagaa tggtacaatt cattgaaaaa accggactgg 2596921 acgccaagcg gaactgcgat cggcatcatt tgggccatcc tgtttgccct gatctccctt 2596981 tcagcagcca ttgtatatgc tgcgttttca tttaaaggtg cgaaaagctt ttggtttaca 2597041 cttttgataa attacgtgct caatcaagcc ttcagctatt tccagtttac gcaaaaaaat 2597101 ctgctggctg catcgcttga ctgcctgctt gtcgccatca cagcaatcgt attactgatc 2597161 attgccaaaa aatacagcag agccgcaagc tatcttcttt tgccttattt tttatggagt 2597221 gcatttgcga cgttcttatc ctttacaatc aattcaatga atctgtgaac aaaaaaagcc 2597281 gcttatacag cggctttttc acatcatcgg cttgatgccc caaatgtcct tcgcatattc 2597341 ccggatcgtg cggtcgctgg agaaatatcc agaatgagca atgtttacaa tcgaatgctc 2597401 agaccatttc cttcgctctc gataatcagc ttgaattcgc tcctgtgcat ctgcatatga 2597461 gctgaaatcc ttcagcacaa aatactcatc attatgcgga agcagcgagt caaagatcga 2597521 ttcaaattca tctgcctctc cttcaaaaaa accattgatc aactgatccg ctacctgcct 2597581 gattctcctg tcatgctgat aatattccct cgacctatag ccgccgtttt cctgatacga 2597641 tagaacctca tccgccttta agccgaacgt gtaaatacag tcagggccca cccgctcaag 2597701 gatctcgata tttgcgccgt catgcgtgcc gatcgtcaaa gccccgttca tcataaactt 2597761 catattccct gtaccagacg cttccttgct tgcggttgaa atttgctcac ttacgtctga 2597821 tgccggaaaa attcgctcag ccatagaaac tctataattt tctaaaaaaa caactttgat 2597881 cagctgtttg accgccggat cataattgac tttttctgcg acagaatgga tcagcttaat 2597941 gattttcttg gcataataat agcttggtga agcctttgcc ccgaaaataa aggtttgcgg 2598001 gtagattgaa aaccccgaat cctccttgag gcggttatac aaatacataa tgtgaagaac 2598061 attcagcagc tgccgtttat atgcatgaag ccgtttcacc tgtacgtcga atatgctctc 2598121 agggttcaca accaccccgg ccgtgcaaaa aatcaaatcg gcaagctctt gttttttctt 2598181 gcttttgttg ttttgaaact gttcaataaa tgcaggatca gtggcgtacg gttctaaacg 2598241 gatcagtgat tccggctgct tgacccattc atcgccgatc gcctctgtaa tgatggcaga 2598301 caagcctgga ttcgctttta acagccagcg cctgtgggca attccattcg tcttattgtt 2598361 aaaacgattc ggaaacagca agtgaaagtc gcgcatctcc ctttccttta atatatcgga 2598421 atgtattttt gcaacgccat ttacactgta gctgcctact atggccagat gagccatttt 2598481 gacaacacca tgcgctgtaa tcgccatgtt ctctatcctt ttccagtctc caggatactt 2598541 ttcccaaact gcacggcaaa acctctcatt gatctcttca ataatcatgt acattcgcgg 2598601 gagcagcggc ttaaacaaat gaatcggcca tttctcgagc gcttctgaca atgttgtatg 2598661 atttgtataa gaaatcgtat gtacagtgat atgccaagct tcttcccagc tcatgttctc 2598721 ttcatcgagc aaaatccgca ttagctcagg caccgcaagc gcagggtgag tgtcattaat 2598781 atgaatgctc acttttttat gcaggccgga taaagattta tgtgttttac ggtaattgtt 2598841 cacaatgctt tttaagcttg cgcatactaa aaaatactgc tgcttcagcc gtaaaatttt 2598901 cccctcatca tgggtgtcat cgggatataa gaattcagaa accgcttctg tttctcgctt 2598961 ataagacaaa atattaccgc cgtgataatg ggcatagggc tcggcgttcc aaagccttaa 2599021 cgtgttgaca gtgcccgttt catagccgat gatcgggata tcataaggaa cagcggtaac 2599081 aattgtcgct tgttcatggc gaaaatgcag gcgcccgctt ttttctgtca tatggacttc 2599141 gccccaaaac ggcacgtcca ctgcttgatc cgcattcctt acttcccata cgttcccgtt 2599201 tttcagccat tgctcaggca gctccacctg atgtccgtct acaatttttt gctcaaacaa 2599261 accatgctta taacgtatgc ccatgccgtg cccaggcagg ttcaacgaag caagcgaatc 2599321 taaaaagcaa gcggccaagc gcccaagtcc gccattgccg agacctgcat cgttctctat 2599381 ctgaaggatc tcctctaaat tgatgccgat ttcctttaaa ccagcttcta caacatcacg 2599441 aacaccaaga ttcattaagt tttgctcaag gagctgaccg agcagaaatt cgattgataa 2599501 ataatatgtc tgcttcccgg aatttgatct gcttttttca ttcgtttcga tccaatcagc 2599561 gctgatatac tctctgacca tattgcccaa cgttttatat tgatccagct tggcagaatc 2599621 tttaaagctt tttccgcacg tcatttccag acgctttaaa aataagtctg caaagcgttc 2599681 tttactcgag aacatcccgt ccactccttg tcacctgctc gaaaatacgc tgatactctt 2599741 tagccgactt cccccagctg taatctgcat tcatagcggt cttcacgatg ctcttccata 2599801 catcctgttg gcaataaaac gacagcgccc tttctatcgt aaatttcaga tcatgcgcat 2599861 taaaggcgga aaacgtaaag ccattgcccg ttccctcttc ctcctgatag gcacggacag 2599921 tgtcgtaaag accgcccgtt tccctgacaa tcggaatggc gccatattga agagcaatga 2599981 gctgccccaa accgcacggc tcaaatttcg acggcatcaa aaacatatca gagcccgcat 2600041 aaatttgatg ggctagcggc tcatcaaacc cgatataagc ccggcacttc tcatgaaaag 2600101 caaattctgc ataccggaaa taatcttcaa attcacgttc tcctgtgcct agcacaacca 2600161 gctgtatgtc ttgctcctca agaagttcgt gcataattct gcggacaaga tcaagcccct 2600221 tttgtttagt gagccttgtc accatactga tcagcggaat atcgtttttc tctggaagcc 2600281 ccatccgctg ctgaagcttc gttttgtttt ccagcttgca tgcaagatcc cctgaatcgt 2600341 attgcgcctc tatataaggg tcgcttttcg gctgatagaa cgtatcatca atgccattta 2600401 atatgccggt tacatcatct tccctatatt gcaaaacctg ttccaactgc tcaccataat 2600461 acggcgtcat gatttcattt ctgtaagtgg ggctcacagt tgtcacatga tcagccgcaa 2600521 tgatgcccgc tttcataaaa ttaacaaatc cgttgcattc taacctttca taatgaaaat 2600581 gatccatctc aagacccagc aagtcatgtg tgacatcagg agggaatatg ccttgaaact 2600641 gcaggttgtg gatcgtgagc acgcttttca tccgttcata aaaaggatgt tttctgtact 2600701 cctctttcag caaataattg accatcgctg tatgccaatc gtgagtatga acaatatcgg 2600761 cttgaacatt cacaactttg gcagcctcca gcacagctct tgaaaaaaag gcaaaccgct 2600821 caccgtcatc ataatgcccg tacaacgaat ccctgttgaa atagtactca ttgtcgatga 2600881 agtaataatt cacatcattc tctgccatat gttcaattcc gcaatattgc tgccgccagc 2600941 cgacagctac ggtacactca gcctgttttt tcatacgctt tttccacggt tcaggtattt 2601001 ggctgtactt cggcagcatc acagctacct cattgcctaa tcgcgcaagc gcctttggca 2601061 gagcacctgc tacatcggca agacctcctg atttcacaaa tggggtgcat tctgacacag 2601121 caaataatat cttcaagaat tcatcagctc tccttgcacc aaaccttttc ttaatacaag 2601181 cggctgctca gctgttcctg cagcttccgt cgccttgccg attttaacat ccttatccga 2601241 aatgacctgc tcaagaagac aatcctctcc aatctgcgtt ttttgcataa taatgcagtt 2601301 tttcagcttc gtaccctttc cgacatggac cgccctgaac aaaatgcagt tttcaacctc 2601361 tccttcaagc acacagccgt ttgccaccaa agaatttttg acagtgctgt gctttccgta 2601421 tttcgtaggc ggctcatcct tcacttttgt atagatcggc tgctgcggca aaaacacctg 2601481 ctgccaaaaa cgaggctgaa tgagctccat actgtgggta taatattttt ccaccgaatc 2601541 aatgacagcg gcataacctg aatattcata agggcaaatg gtcagggcgg aagattcctt 2601601 ttcaacagcc tcctgaatgg ttttatagcc tttttcgcta tgtccgtaga tcagatcctt 2601661 taaaagcgtt gttgacatga tatagatttg cagcgactgg ccgtcctgaa atacctcggt 2601721 gacgtcgcag ccaacctcct gatggcgttt cagcacatat tgaaattgaa tgttgcatac 2601781 ggtatggctg ttggagatta cagcatattg ctgagtgctt ctgtggaagt aatctagatg 2601841 gtccgaaaac tggcgaaagg aaccgaattc atcgtattcg tgatgaagat ggggagacgg 2601901 gaaaaaaaag aggccgtcct ttttccggtg caaatcccat tccttacccg ccccaaggtg 2601961 atccatgagc gaacggtaac gatacttcgg aaaaattgca acactcctaa tatccgcatt 2602021 caccatgttg gaaagcataa aatcaatcag tcggtacctg ccggcaaaag ggatcgcccc 2602081 gagcgaccgc tgtgctgtta aatcctgaag agaatgctta tatgtggttt catctataac 2602141 acctaacatt tgattattga acactgactc tgccccctct tcagtaatta aatcaattct 2602201 ttttctacaa attcctctga aacgagcagc acctcttcaa tgtctttttc ggagcgaatc 2602261 actgcgccat ccggcagcac catcccatta ggaacgatgg cattttcaat gactacatgc 2602321 tccccaatcg tcacatccgg cattatgacg gatgatgtaa cagtcgtatg cttaccaaca 2602381 gtcacacctt gaaaaagaac ggagtgagac acatttccat atacaacaca accttcgttc 2602441 acaagcgaat cttgaacctg cgcatcagat gaaataaatt gcggaggctg atttggattg 2602501 acggagtaaa ttttccattt gcgttcaaac agcttcagct ccgagtcctc ttttaacaaa 2602561 tccatattgg cttcccacaa gctctgcacc gttccgacat ccttccaata tcccttgaac 2602621 ggataagcag aaagcttctt tttctcttcc aaaagcagtg gaataatgtc tttgccgaag 2602681 tcgtggctag aataagggtt ttgatcgtcc atctcaagat actgtttcaa aagcggccaa 2602741 ttgaatatat aaattcccat tgaggcaaga ttgctcttag ggaatttggg cttttcatca 2602801 aaatgtgtga tcgtcccatc tggattggcc ttcatgatgc cgaaccggct tgcttcctcc 2602861 cagcccactt cgatgacaga gatggtcaca tctgctttct tttcaatgtg ataatcaagc 2602921 attttgccgt agtccatttt gtatatgtga tctcctgata aaatcagtac atactcagga 2602981 tcatactgat tcaaataatt gagattttca taaatggagc ttgccgtccc tttataccat 2603041 ttgacttctg atgactcggc ataagggggt aaaaccgtca cgccgccatt atatctatcc 2603101 aggtcccatg cactgccgat cccaatatag gaattcagct cgagcggctg atattgcgtt 2603161 aaaatcccga ctgtgtctat gcctgaatta gaacagttgc ttagggtaaa atcaataatc 2603221 ctgtattttc ccccgaaaga tacagccggt ttggccatat tttttgttaa tccgctgaga 2603281 cggctgccct tcccgccggc aaggagcatg gctacacatt gttttttcat ctttttatct 2603341 ctcctctttt tttaaccgcc cgtaaaatcg agatgccgta aggggggatg gtcatcgtga 2603401 tataacacgg tttatgatga agtgctccct ttttagccga taacggcttt ttgttgattt 2603461 gccctgagcc tccatatgtt tcactgtcac tgttaagcac ttcaatgtat tgagtaaaaa 2603521 aaggaactcc aacatcatat tgatgataga ccacgggtgt aaaattacaa atgatgacaa 2603581 gcgcctcacc gtgcttttgg ccataacgaa taaaagaaaa gattgattgt tcgtcattat 2603641 ggacatcaat ccattcaaac gattgtgcac gatggtcatg ctcataaagg attttgcttt 2603701 tttggtaaaa gcggagaaga tcttgcgtaa aaacgctggc tttctgatgc atggggaagg 2603761 agtccaaaaa ccaatcaagc tgttctgtat ctttccattc atcaaattga gcaaactctg 2603821 atcccataaa gatcaatttc tttccgggat gcactgtcat atagcccagc aaaagccgat 2603881 actgggcaaa tttctgccag tagtcgccag gcattttatt gagaagtgat ttttttccgt 2603941 atacgacttc atcatgagaa aacggcaata caaaatgttc actaaacgca tatagtaatg 2604001 aaaaagagat aagctgatga caatgccgcc tttcttcggg cggcgtctcc atgtatttca 2604061 gtacgtcatt catccatccc atattccatt tataatgaaa accaagcccc ccttcctcaa 2604121 cggcacctgt cacttgaggc cattctgtag aatcttctgc aatcatcatc acatggggat 2604181 atgcctctct catggtttga ttgagttttt ttaaaaaatc aacagcatat ggattcgtgt 2604241 ggcgttcatc ctgatttggc caatacaaga tattagccac tgcatcaacc ctaaatccat 2604301 ctatatgata gaattccgcc cagtacaacg cattcgaaat taaaaaacta tgaacttccg 2604361 gtttccccag gtcaaagttt gccgtgcccc ataaccagtt ctcccgatca cgttcttctt 2604421 tgtattcata aagcggttct ccatcaaaca tataaaggcc atgtgcatct ttacaaaaat 2604481 gtccggggac ccaatccaaa atgactccga tattttgttg atgacattca tccacaaact 2604541 tcatcagatc atgcggcggg ccaaacctgc ttgtcgggct gtaatacccc gttccttggt 2604601 acccccatga acgatcatat ggatgctcat acacgggaag cagttcaata tgggtaaacc 2604661 catgcttctt gatataaggg ataagcgtct gacttaattc tttataggaa taatgcctgc 2604721 catcagaatg cttcttccaa gacccaagat gcagttcata aatgaaaaca ggtttttcat 2604781 acagcgtctt agccttctgt ttcttttgcc atttttgatc ttgccagctg tatccttcca 2604841 aatcgtaagt aagtgacgct gtgtttggtc tgacttctga ataaatagcg tatggatctg 2604901 ccttcagcct gatctcaccg ttattcgtca caatttcgta tttatatcgt tccttttctc 2604961 ctatacctgg aataaataac gtccaaatgc cattatcatt cactctgtgc atcacatgct 2605021 cttctccaga ccagctgtta aaatctccag ccactcgtac ttccgacgca tgaggcgccc 2605081 acacacagaa ttcatatccg cttttgccat tcagctcgcg gtaatgcgag ccaaacagct 2605141 gatagctttt aaacagactg ccttcgtgaa aaagataaac atcatgtgct gtcgggctgg 2605201 cagcggccat gtaatcatcc tttctgacat catagttttc atttatagta tttattcgaa 2605261 gaaataaaaa aaagcccttt cctgaaagcg cttatactta tagacaatta acttcatttt 2605321 ctgaagaaaa acgaaatata tggagatttt tgtagtctgt ttttaaaata aagaacaaaa 2605381 tctaagacat atcatgattt ataaaaacaa aaaaaccttg caggatatgc aaggcttctg 2605441 gatgacccgt acgggattcg aacccgtgtt accgccgtga aagggcggtg tcttaaccgc 2605501 ttgaccaacg ggccgataat tatgatatct gtaatcatat ggcggagaag gagggatttg 2605561 aaccctcgcg ccgcttacac gacctacacc cttagcaggg gcgcctcttc agccacttga 2605621 gtacttctcc atttggctcc acaggcagga ttcgaacctg cgaccgatcg gttaacagcc 2605681 gatagctcta ccactgagct actgtggaac aaaagtcatg gtgggcctga atggactcga 2605741 accatcgacc tcacgcttat caggcgtgcg ctctaaccag ctgagctaca ggcccatgac 2605801 gatatagaaa tggagcgggt gatgggaatc gaacccacga catcagcttg gaaggctgag 2605861 gttttaccac taaactacac ccgcaatttt tatttggggc gattgatggg aatcgaaccc 2605921 acgaatgcca gagccacaat ctggtgcgtt aaccacttcg ccacaaccgc caaagcatat 2605981 tgataaatgg tggctcggga cggaatcgaa ccgccgacac acggattttc agtccgttgc 2606041 tctaccaact gagctaccga gcctaagtat ttaaatggcg gtccggacgg gactcgaacc 2606101 cgcgacctcc tgcgtgacag gcaggcattc taaccaactg aactaccgga ccattttaaa 2606161 atttggttgc gggggcagga tttgaacctg cgaccttcgg gttatgagcc cgacgagcta 2606221 ccgaactgct ccaccccgcg atgattagga atatgtatgg cggaggaaga gggattcgaa 2606281 cccccgcggg ctttgacacc cctgtcggtt ttcaagaccg atcccttcag ccagacttgg 2606341 gtattcctcc gtatagtggt ggaccttgta ggactcgaac ctacgaccgg acggttatga 2606401 gccgtctgct ctaaccaact gagctaaagg tccattggta gcggcggagg ggatcgaacc 2606461 cccgacctca cgggtatgaa ccgtacgctc tagccagctg agctacaccg ccaaatattt 2606521 ttgaaatcaa gtggagccta gcgggatcga accgctgacc tcctgcgtgc aaagcaggcg 2606581 ctctcccagc tgagctaagg ccccaagaat ggtcgggaag acaggattcg aacctgcgac 2606641 cccatggtcc caaaccatgt gctctaccaa gctgagctac ttcccgattt catatagatc 2606701 atggcgcgcc cgagaggagt cgaaccccta accttttgat ccgtagtcaa acgctctatc 2606761 caattgagct acgggcgcaa aacttaatgc cgagggccgg acttgaaccg gcacggtagt 2606821 cacctaccgc aggattttaa gtcctgtgtg tctgccaatt ccaccacccc ggcgtggatg 2606881 gtatagttgg agcggaagac gggattcgaa cccgcgaccc ccaccttggc aaggtggtgt 2606941 tctaccactg aactacttcc gcagaaatgg tgcggatgaa gggacttgaa cccccacgtc 2607001 tgtaaagaca ctagagcctg attctagcgc gtctgccaat tccgccacat ccgcaacatg 2607061 taaatggtga gccatgaagg actcgaacct tcgaccctct gattaaaagt cagatgctct 2607121 accaactgag ctaatggctc ttcttacaat agacttgaat attatatcat ataaaagtgg 2607181 tgccggcaag aggacttgaa cccccaacct actgattaca agtcagttgc tctaccaatt 2607241 gagctacacc ggcatatatg taaaaccgat atgtataatg aaaaatggtg gaggatgacg 2607301 ggctcgaacc gccgaccctc tgcttgtaag gcagatgctc tcccagctga gctaatcctc 2607361 catacttgca ctaacgtgca attgcttggc ggcgtcctac tctcacaggg ggaaaccccc 2607421 gactaccatc ggcgctgaag agcttaactt ccgtgttcgg tatgggaacg ggtgtgacct 2607481 cttcgctatc gccaccaaac aaattgagag tgttctctca aaactagata acaggtgtga 2607541 catcattcaa aaatatggtt aagtcctcga tcgattagta tctgtcagct ccatgtgttg 2607601 ccacacttcc acctcagacc tatcaacctg atcatctttc agggatctta cttccttgcg 2607661 gaatgggaaa tctcatcttg aggggggctt catgcttaga tgctttcagc acttatcccg 2607721 tccgcacata gctacccagc gatgcccttg gcagaacaac tggtacacca gcggtgcgtc 2607781 catcccggtc ctctcgtact aaggacagct cctctcaaat ttcctgcgcc cgcgacggat 2607841 agggaccgaa ctgtctcacg acgttctgaa cccagctcgc gtaccgcttt aatgggcgaa 2607901 cagcccaacc cttgggaccg actacagccc caggatgcga tgagccgaca tcgaggtgcc 2607961 aaacctcccc gtcgatgtgg actcttgggg gagataagcc tgttatcccc ggggtagctt 2608021 ttatccgttg agcgatggcc cttccatgcg gaaccaccgg atcactaagc ccgactttcg 2608081 tccctgctcg acttgtaggt ctcgcagtca agctcccttg tgcctttaca ctctgcgaat 2608141 gatttccaac cattctgagg gaacctttgg gcgcctccgt taccttttag gaggcgaccg 2608201 ccccagtcaa actgcccacc tgacactgtc tccccgcccg ataagggcgg cgggttagaa 2608261 ggtcaataca gccagggtag tatcccaccg atgcctccac cgaagctggc gctccggttt 2608321 ccaaggctcc tacctatcct gtacaagctg taccaacatt caatatcagg ctgcagtaaa 2608381 gctccacggg gtctttccgt cctgtcgcgg gtaacctgca tcttcacagg tactataatt 2608441 tcaccgagtc tctcgttgag acagtgccca gatcgttgcg cctttcgtgc gggtcggaac 2608501 ttacccgaca aggaatttcg ctaccttagg accgttatag ttacggccgc cgtttactgg 2608561 ggcttcaatt cgcaccttcg cttacgctaa gcgctcctct taaccttcca gcaccgggca 2608621 ggcgtcagcc cctatacttc gccttacggc ttcgcagaga cctgtgtttt tgctaaacag 2608681 tcgcctgggc ctattcactg cggctctctc gggcttgcac cctaacagag caccccttct 2608741 cccgaagtta cggggtcatt ttgccgagtt ccttaacgag agttctctcg atcaccttag 2608801 gattctctcc tcgcctacct gtgtcggttt gcggtacggg cacctctcac ctcgctagag 2608861 gcttttcttg gcagtgtgga atcaggaact tcgctactat atttcgctcg ccatcacagc 2608921 tcagccttat gggaaacgga tttgcctatt tcccagccta actgcttgga cgcggatatc 2608981 caataccgcg cttaccctat cctcctgcgt ccccccattg ctcaaatggt gaggaggtgg 2609041 tacaggaata tcaacctgtt gtccatcgcc tacgcctttc ggcctcggct taggtcccga 2609101 ctaaccctga gcggacgagc cttcctcagg aaaccttagg cattcggtgg aggggattct 2609161 cacccctctt tcgctactca taccggcatt ctcacttcta agcgctccac cagtccttcc 2609221 ggtctggctt cacagccctt agaacgctct cctaccactg ttcgaagaac agtccgcagc 2609281 ttcggtgata cgtttagccc cggtacattt tcggcgcaga gtcactcgac cagtgagcta 2609341 ttacgcactc tttaaatggt ggctgcttct aagccaacat cctggttgtc taagcaactc 2609401 cacatccttt tccacttaac gtatactttg ggaccttagc tggcggtctg ggctgtttcc 2609461 ctttcgacta cggatcttat cactcgcagt ctgactccca aggataagtc attggcattc 2609521 ggagtttgac tgaattcggt aacccggtag gggcccctag tccaatcagt gctctacctc 2609581 caagactctt accttgaggc tagccctaaa gctatttcgg agagaaccag ctatctccag 2609641 gttcgattgg catttcaccc ctacccacac ctcatccccg cacttttcaa cgtgcgtggg 2609701 ttcgggcctc cattcagtgt tacctgaact tcaccctgga catgggtaga tcacctggtt 2609761 tcgggtctac gaccacgtac tcatgcgccc tattcagact cgctttcgct gcggctccgc 2609821 atcttctgct taaccttgca cgggatcgta actcgccggt tcattctaca aaaggcacgc 2609881 catcacccgt taacgggctc tgactacttg taggcacacg gtttcaggat ctctttcact 2609941 ccccttccgg ggtgcttttc acctttccct cacggtactg gttcactatc ggtcactagg 2610001 gagtatttag ccttgggaga tggtcctccc ggattccgac ggaatttcac gtgttccgcc 2610061 gtactcagga tccactcagg agagaacgaa gttttgacta cagggctgtt acctcctatg 2610121 gcgggccttt ccagacctct tcatctacct cgttcttttg taactccgta cagagtgtcc 2610181 tacaacccca agaggcaagc ctcttggttt gggctgatcc cgtttcgctc gccgctactc 2610241 agggaatcgc atttgctttc tcttcctccg ggtacttaga tgtttcagtt ccccgggtct 2610301 gccttctcat atcctatgaa ttcagatatg gataccactc cattacgagt ggtgggtttc 2610361 cccattcgga aatctccgga tcaaagcttg cttacagctc cccgaagcat atcggtgttc 2610421 gtcccgtcct tcatcggctc ctagtgccaa ggcatccacc gtgcgccctt tctaacttaa 2610481 ccgttaaaaa gaatcactat gtgatatctt gtgttactaa ttgaatgtga tgtctactgt 2610541 tatctagttt tcaaagaaca cgtttcgaag gaatgatcct tcaaaactaa acaagacagg 2610601 gaacgttctg tttataagac cttgggtctt atattccgta taatatcctt agaaaggagg 2610661 tgatccagcc gcaccttccg atacggctac cttgttacga cttcacccca atcatctgtc 2610721 ccaccttcgg cggctggctc ctaaaaggtt acctcaccga cttcgggtgt tacaaactct 2610781 cgtggtgtga cgggcggtgt gtacaaggcc cgggaacgta ttcaccgcgg catgctgatc 2610841 cgcgattact agcgattcca gcttcacgca gtcgagttgc agactgcgat ccgaactgag 2610901 aacagatttg tgggattggc ttaacctcgc ggtttcgctg ccctttgttc tgtccattgt 2610961 agcacgtgtg tagcccaggt cataaggggc atgatgattt gacgtcatcc ccaccttcct 2611021 ccggtttgtc accggcagtc accttagagt gcccaactga atgctggcaa ctaagatcaa 2611081 gggttgcgct cgttgcggga cttaacccaa catctcacga cacgagctga cgacaaccat 2611141 gcaccacctg tcactctgcc cccgaagggg acgtcctatc tctaggattg tcagaggatg 2611201 tcaagacctg gtaaggttct tcgcgttgct tcgaattaaa ccacatgctc caccgcttgt 2611261 gcgggccccc gtcaattcct ttgagtttca gtcttgcgac cgtactcccc aggcggagtg 2611321 cttaatgcgt tagctgcagc actaaggggc ggaaaccccc taacacttag cactcatcgt 2611381 ttacggcgtg gactaccagg gtatctaatc ctgttcgctc cccacgcttt cgctcctcag 2611441 cgtcagttac agaccagaga gtcgccttcg ccactggtgt tcctccacat ctctacgcat 2611501 ttcaccgcta cacgtggaat tccactctcc tcttctgcac tcaagttccc cagtttccaa 2611561 tgaccctccc cggttgagcc gggggctttc acatcagact taagaaaccg cctgcgagcc 2611621 ctttacgccc aataattccg gaaaacgctt gccacctacg tattaccgcg gctgctggca 2611681 cgtagttagc cgtggctttc tggttaggta ccgtcaaggt accgccctgt tcgaacggta 2611741 cttgttcttc cctaacaaca gagctttacg atccgaaaac cttcatcact cacgcggcgt 2611801 tgctccgtca gactttcgtc cattgcggaa gattccctac tgctgcctcc cgtaggagtc 2611861 tgggccgtgt ctcagtccca gtgtggccga tcaccctctc aggtcggcta cgcatcgttg 2611921 ccttggtgag ccgttacctc accaactagc taatgcgccg cgggtccatc tgtaagtggt 2611981 agccgaagcc accttttatg tttgaaccat gcggttcaaa caaccatccg gtattagccc 2612041 cggtttcccg gagttatccc agtcttacag gcaggttacc cacgtgttac tcacccgtcc 2612101 gccgctaaca tcagggagca agctcccacc tgtccgctcg acttgcatgt attaggcacg 2612161 ccgccagcgt tcgtcctgag ccaggatcaa actctccgat aaatggatca caggttaagt 2612221 tcaccgcatc ctgcggcgac acctgtgtga cctgcgtcgt gcaggcccta gtttgactga 2612281 ctacgcacat cgcagtgcga tttttaaaaa ctgaattaac aggtacgttt tgtcttgttt 2612341 agttttcaaa gatcatttcg ttacttctca atgaagcagc tttactaata taacattcag 2612401 cttctttttt gtcaacaact tttttcaagt tgttttgaag catctagttt gtgtccgctg 2612461 tgcatcagcg acgtttaata atataacacc tgtatttatt tattgcaata gttttttaaa 2612521 aaaaatctat aaaacaaata aactataatc ctcgccatga tttctaaagc gtgtgtatca 2612581 tataagtttc ttaaaagaac atatacatca gtcatgtgat cttgttgttt ttttcgtttt 2612641 cttgtatagt agaaacgaac taaatactga tgaccacaag gggagcatta aagctgagag 2612701 tgagcggttt cgttctgacc ctttgaacct gttagttaac gctggcgtag ggatgtggca 2612761 aagtcaaatg aattgcagat cgtaaagcag tgcgtggaac ttttctcatc cttccgcgtg 2612821 ctgctttttt gttgtccttt tggttgtctg tcaatggaag gagatagata tgaatcaatc 2612881 taagcaactg gttcgcctta ttgaaattgc cattatgaca gcggcagccg ttattttaga 2612941 cattgtctca ggaatgtttc ttagcatgcc tcaaggaggc tcggtctcca tcatgatgat 2613001 tccgatcttt ttaatttcgt ttcgctgggg tgtcaaagca ggtcttacta caggtttgtt 2613061 gacaggtcta gtacaaatag caatcggaaa cttgtttgct caacatcctg tacagctatt 2613121 gttagattac attgtcgctt tcgcagcaat cggcataagc ggctgtttcg cttcttctgt 2613181 ccgtaaagcc gctgtatcaa aaacaaaagg gaaattgatt gtttcagtgg tcagcgcagt 2613241 ttttatcggc agtttgctgc gctatgccgc gcatgtcatt tcaggagctg tgtttttcgg 2613301 cagctttgct ccaaaaggaa caccggtatg gatttattct ttaacttata atgcgactta 2613361 catggttcct tcattcatta tttgtgcaat tgtcctatgt ttattattta tgacagcacc 2613421 ccgtctgctt aaaagtgaca aagcgtaaaa gtaacaatcc cccagcgaat tccgctgggg 2613481 gatttttcgt tatctgttaa gaagtgtttt taaagctgaa agatccggcc agccaagacc 2613541 tacttctttc agccttactc cggcaatttc aaagttgtcc tccgctactc tttcaggtga 2613601 ataggcctga taaaatataa tcgagggatt ctgctcaata acccaaacaa acatacttga 2613661 aaaaccatgt tgaagcaaaa actccgctcc ttttgctaag agcgccctgc ctgcaccttg 2613721 ccgctggcgc tcttccagaa gataaatagc gtataactcg ccgtcatagc cttcttgttc 2613781 agagcgaata ggtccaaatg aagcaaagcc gaatactgaa cccttttcgt cctgagcaac 2613841 aaatactccc tttaacgagc gacttttcca tttgtcttca aattccttat agttcaggct 2613901 gtttaaataa tcaatcggga taatttcgtg gtatgttgtc ctccagctgt ctacatgcac 2613961 ttttgcaatg tcctttatat cctctaactt cgcttcacgt acagttacca tacggttctg 2614021 ccctttcctt actctgattt ttggatcgtt ttggcttctt tgatttcatt tgttaattca 2614081 ttaatgcttt gttttacgtt tccttttcct gaaaagttct caagcatttc ttttacatca 2614141 attcctgagg atgcttttaa actttcttgc agacttgaca ttaagttcgt cgcatagctg 2614201 gttactttgt ttgctccgct tgattcaccg cttcctcctg tatcgacaac ggtgatttta 2614261 tcaatatttg aaagaggtgc cgctgcttgt ttcgcgtatt ccggaagcat tttgacaatc 2614321 atatcgaaaa tcgccgcctg cccgtactgt tcaaaggcgg ccgcaatttt ctcttttgct 2614381 tccgcttctg caagaccttt caggcggata acctctgctt ctgtctctcc tttcgctttt 2614441 tccgcttctg cttttgctag cccgtcaatt cttacttttt ccgcctcagc ctttgccatt 2614501 gcttcaatac tgtacttctt ggcatcggct tccgcgagct gtttggcttt ctcagctgct 2614561 gcggactgct caacagaata acggtctgca tcggcttttt tctttacctc tgagtcgtat 2614621 tgacgttcac ggcgaagaat ttctttttct tctagttcta tttgtttttg gcgttcgata 2614681 attttaacct gcatttcctg ctctgtgact tgctggcgcg ctcgggcagt ctctaaatca 2614741 tatgcttggt cggcattcgc ttttgccgta tcttgttctc tgcggaattc agccattttg 2614801 agctgattga ttttttcagc ttcagcgatt tccgtcgccc gttcaagttc tgattttttt 2614861 gcgtctttat cggcttctgc ccgcttaatt cgggtttctt tatcagcctc tgctgttgcg 2614921 atatcagcat cgcgttttac ttgggcaatt ctcggtttcc ctaatgattc aagataaccg 2614981 tttttatcac gaacatcttt aatggtaaac gagacgatta caagtcccat tttcgcgaga 2615041 tcctgtgaag cgacacgctg cacctcttga gagaattttt ctctgttttt atagatttct 2615101 tctactgtca ttgagccgag aatggaacga aggtggcctt ctaaaacctc ccgcgcttcc 2615161 tgctcacggt cgtcttttga tttccctaaa aattgttcgg ccgctgtagc gatttctcct 2615221 atagaaccgc cgattttaat aatcgcagtt ccatcggcca ttactggcac tccttgttct 2615281 gtatagactt caggtgtcga aacatcgagt ttgcttgata ataggcttag cggctctgcc 2615341 tgctggaaga cgggaaggac aaaggttcct ccgccgcgga cgattttaat acggttgccg 2615401 ccttcatcga catgaacatt tttattaccc agatagctcc ctgttacaat taacgcttca 2615461 tcaggccctg ctgtacgata cttcgtaata aacacagcta ttagtgcaat taataaaaag 2615521 aatacaactc cgatgatcat tataatcggc attgtcatat caaattcctc cttttatgtt 2615581 aaatgggttc atgcggagta accgaaagaa ctccgttgtt aatatctacg actaacaccg 2615641 ttgtcccgta actgatctgc tgattatcaa aactgaccgc tgactttgaa atggtcccgc 2615701 ctatcccttc tatgaccact tcaccaaacc cgtcaaccgg cacagctgta atcactttac 2615761 cgagtcttcc tctgagatca tcttctctat atgccaatga ttcttctgca gatgataatg 2615821 gcaccagtac aaagatgtga agcaatacca ccagcatgat cgaaaggatg caagataaaa 2615881 gcgcaatcag caagcttgac agaggcaata caagttcacc tatatatccg cccgctgaaa 2615941 aacatgtaaa aaatgagagc actaatgtcg gattaagaaa cggaatgcct tctgacagcc 2616001 ctgaaaatac atctccgaaa aacaggaata acagcgtaag gctgcccgca ataataagcg 2616061 tataaagata cattgtttgt ataggtactc caaataactc caacttcctc atcctttctt 2616121 catcaatgca ttgatgaacg gctgccgtta ccatttatac gagacacctc gggaaaagtt 2616181 tcaaaatttt aagacaaata acccatttga agtgctttat aaatgataat tgcttatata 2616241 tatggtaatg tcattttagg aggagatatg atgagtatct ttaatgaagc cagattagaa 2616301 acgtggaacg aattgaaagg actttctgac gaaaagctga atcaaaagcc ttctgctgaa 2616361 gaatggagca tacgggaagt tcttgaccat ttgaaaaaaa tcgatatgac cgcacaaaaa 2616421 atgttgaagg aacgtgtaaa ggacgctccg attaaagaaa ttgaagaaaa accgcttgaa 2616481 gtagcacagg acagaaataa taaacggaaa gccccgagtc atcttgagcc tgcgcatgat 2616541 tttatttcag gcagccaaat gaaacgtgag cttgatgtgg taagagagca gctgactgct 2616601 gcgattgcct ctctgaaaga agaagatttt gaaagagtgc ttccgcatcc tgtgtttcaa 2616661 gagctgactg tcagacagtg gatcgatttt atcggccatc atgaaaaacg gcacctcagc 2616721 caaatgaaag aaattaaaga aaagatagaa agggcctgat ttaatcagac cctttctgct 2616781 tttcgtttga cttttcgctg ataggaatga acttctattt catcacctgt gtaaacagca 2616841 ccaggtctct ccacaataca gacaatccct ctaatgccca gtgcgtggcg gacgaaagcc 2616901 gacgccagct tcggttggtc cggataataa gactgaatga cttctcccgg ctggatacac 2616961 ggatcatttt cgccctcaca cagcagagcc gctccgctcg gaaaaataat ccggcttcct 2617021 tcttttaatg aagtaagatc tggcataccg ctgactgcca cattcgcccc gagccattcc 2617081 ggcaaaattc tcggcactcc catttttaaa gcgatttcgt tgcattcctc tattgaaaca 2617141 attgaaattt gtctgcggtt gaaaatttca gtccctcttg aaaacattgg ttctctggct 2617201 cccgcttttt tggtcaggcc aaaatgcaag tcgccgggga tgccgccata atcaaaatca 2617261 agcttgtcca tttgctttgt tacgaagctt tttgtatctg cgatatataa gccttccgct 2617321 tttgcagtca tacgcttcca catcagctgg caccttcctt cttatctaaa atttccacct 2617381 atgcttcatt atcccaaaaa atcccgctct gtaaaggagc gggattttga ttataccgtt 2617441 ttaggcgtaa ggttaaagca gcgtttgtag atccagttgt atgctttttc atttaaatct 2617501 ctagggtttc cgaaggtttg cggatctttc attgcttctt tagacaagcg ttcgatcata 2617561 tcaggtgata ctccctgctc ttctaaagtc ggcacttcta aatcttcgac cagatcatac 2617621 atccaattga cagatgcttt cgcagcttct tctgttgtca tcttgcttgt atcaataccg 2617681 aacgctttcg caatacgcgc aaacttctca ggatagccct tccagttgta ttccatgaca 2617741 gggcccatca tcgccgctac acattggccg tgagcgactg ggataatacc gccaagcgtt 2617801 tggctcatcg catgagcagc gcccgctgat tcacttccgt aagaaagacc ggcaagcatc 2617861 gcagcctgcg ccattccgta ccttgcttcc agatcctctc catcagcaaa tgccctcttg 2617921 atgtaatgag cggcatactc aatcgccatt aaggcaaccg catccgtgat tggctgtgca 2617981 aatttcattg tatagcactc aatggcatgg gcgagcgcat caattcccgt catagctgtt 2618041 acatgcggag gcattgaaac atgaagctca ggatcaatga ttgtcaagtg cgctgcaatc 2618101 agcggaccgc ccgtgttgaa tttgaattct ctttcttcat ctgtgataac cgcccattgg 2618161 gttacttctg atccggttcc agctgtagtg ggaattgtcg tcagcggagg aatgcggttt 2618221 tccagcggtt ttttcccatc tgccgcttca taatcaagca cgcttccttc gtgagtcgct 2618281 tctactccga ttgcttttgc tgtatccatg gagcttccgc ctccgactgc caccaaacca 2618341 ttacagttct cttttttgta aagctcagat ccttcattca ccagacggac aggcgggttt 2618401 ggctcaactt tattaaagag taccacttca atgcctgctt ctttaagtga ttcgattacg 2618461 ggatcagcaa caccggcttt ataaatccca gggtctgtga caaggagcgc ttttgaaacg 2618521 cccagtgcag ctacttcctc acccgtatgc ttgatggctc cgattccatg cttaatcaca 2618581 gtcggaattt caaatgtgtg gaatttctgc atgctttcta ccttcatatt taatgtcatc 2618641 atcaatctcc ccctcttatg aattaaacca gttaaccgct gccggttttg tattgcggta 2618701 tacatgtttg acttctgtgt attcttcaag gcctattttt ccaagctcgc gtccgaaccc 2618761 ggattgctta tatccgcccc atggcgcttg tgcaaagtac ggatgaaaat cgttgatcca 2618821 aacggttccc attctcaagc gggctgctac ccgttcgcac ttttcaatgt cttttgacca 2618881 taccgctcca gccaagccat agatggtatc attcgcaagc tcgattacct cttcttcaga 2618941 gctgaaggtt tcgactgtca atacaggacc gaaaacctct tcctgaacga ttctcatgtc 2619001 agaattacag tttgagaaaa tagtaggttc atagaaaaag ccgttttgaa gctcaggatc 2619061 ttccgggcgt ttgcctcctg tctccagctt cgcgccttcc tctattccga tctctacata 2619121 tttttctacc tttgccctgt gctccgccga aataagcgga ccgctttctg tctcagcatg 2619181 aaaaccgttt ccgagtttta tgcgttttgc ccgtttgacc agctccgcca aaaattgatc 2619241 atgaatggca tcctcaacaa gcaagcggga acctgcagag catacttggc cggcgtggaa 2619301 aaatacagcg tttaaggcct gatcaaccgc aacttctaaa tccgcgtcct tgaaaacaat 2619361 atttgggttt ttcccgccaa gttcaagggc gatttttttg acgtttccgc ttgccgcccg 2619421 catgattttt ttgcctgttt caattccgcc cgtaaatgaa atcaaatcga cgtctttgtt 2619481 tacggcaagc tcgtcgccca ctgtggctcc cggtccaaga acaagatttg cgacaccttt 2619541 tggaacaccg gcttcttcca tcagcttaaa gactttgatt gtcgtcagcg gcgtaatctc 2619601 actcggcttc atgacgattg tgtttcctgc ggccagtgca ggggcgattt tccagctcgc 2619661 ttgaaggagc ggataattcc atggagtgat ctggccgcaa accccgattg gctccctaat 2619721 aattttgctt tctgaatcag gaatcggaga tgaaatgatc tctccgccat ctttgtctgc 2619781 caagccggcg taatattgaa aaacattggc gatatcgtcc atatcggcct tgctttcttc 2619841 gagtgttttt cctgtatcaa gagattcaag ctcagccagc tcctcaagat cgcgtctgat 2619901 taattccgca attttcagaa caatttttcc gcgttcaagc ccggatagcg atgaccattc 2619961 tcctttgtca aatgctctac gtgcggctgc gattgctttg atggcgtcct ctcgccctcc 2620021 ctcgcttaca gttgcaattt cttcttgatt aaatgggttg ataatactgc ggatctgttc 2620081 tttttcggca ctgatccatt ctccgtcaat gaataatgtt tgactcatat aagcctcctt 2620141 gacgtaaata aagtttgtta aataaaaatt taatgttttt aacaacctta atctaacata 2620201 tggtttttaa actgtcaaag tcccattttg atttttcttt ttgacttttc ctcatgtttc 2620261 gttaagataa agaacataaa gaaataactt aacgaattta attttctaaa ggaaaagagg 2620321 gtcagtatgg atgaaaatcc agaatttgca gctatagaac aggctcggga tcttgttatt 2620381 gactccattg ctgaaacgat ggatctttac ggaattaccc gcagtgtcgg gattttatat 2620441 gggacgatgt atatgaggga tgagatgacg cttgacgaaa tgcgtgagga gttgcaaatg 2620501 agcaaaccaa gcatgagcac tggcgtcaaa aagcttcaag acttaaatgt agtgaaaaaa 2620561 acatttcacc ggggcatccg caagcataca tttgtggctg agaaggattt ctttaaattt 2620621 ttcacaaatt tctttccacc taaatgggag cgggaggttc aagtgaatgt aacagcgatc 2620681 gaggaagctc aagctgattt acaaaaggtt ttatgcaagg aagatctcga tgaggatatc 2620741 aaaaatgaag cactgcagtt atatgatcag ctggaaagct ctaaagctta ctatgactgg 2620801 ctgaaacggc ttgctgaatc ggtgcagacc ggagaaattt ttaaatttat accggtcgaa 2620861 acaaagtaaa gcagaaaacg cctgggaaac taggcgtttt tttgatgtaa ctactacaaa 2620921 tttgaaaaat acgggaaaaa caccccattt acttccaaaa tatttgatgg taattttatg 2620981 taggtaaaat ttgtatttgg cctttcagag gaggtgaaaa gcgggcaggc ctgtttaatt 2621041 tatcattttt tagggggaat tttgttatga aacgcaaatt attatcttct ttggcaatta 2621101 gtgcattaag tctcgggtta ctcgtttctg cacctacagc ttctttcgcg gctgaatcta 2621161 catcaactaa agctcatact gaatccacta tgagaacaca gtctacagct tcattgttcg 2621221 caacaatcac tggcgccagc aaaacggaat ggtctttctc agatatcgaa ttgacttacc 2621281 gtccaaacac gcttctcagc cttggcgtta tggagtttac attgccaagc ggatttactg 2621341 caaacacgaa agacacattg aacggaaatg ccttgcgtac aacacagatc ctcaataacg 2621401 ggaaaacagt aagagttcct ttggcacttg atttgttagg agctggcgaa ttcaaattaa 2621461 aactgaataa caaaacactt cctgccgctg gtacatatac tttccgtgcg gagaataaat 2621521 cattaagcat cggaaataaa ttttacgcag aagccagcat tgacgtggct aagcgcagca 2621581 ctcctccgac tcagccttgc ggttgcaact aatgtaaaag accggttaac gccggtcttt 2621641 tttgcgtttt accctcccct ttttctctaa tccccgttat cttttttctg gtttaaaatt 2621701 taaattgaca aacactagaa acaggagtaa attcttgagt gttcaatttc atacagtctc 2621761 ttttaccgct taatcaaaca cgaacggggg aaccaacgat tggctgtttt attaacagcc 2621821 ttggggtgaa tcttactaag taagaggggg tactctgaat ccctaatccg acagctaacc 2621881 tcgtaggcgt atacagagag gaggtctatt atcggccatt ctttgcaatg gtcttttttg 2621941 tttcaaaaac gttaattcac taagggagat atgaacattg ggaagaatta aaaataagca 2622001 atttgccgtg atcgggctgg gccggtttgg cggcagcatt tgtaaagaac ttcatagaat 2622061 ggggcatgag gtccttgcgg ttgatatcaa cgaagaaaag gtcaatgcat atgcttctta 2622121 cgccactcat gcggtaattg ccaacgccac cgaagaaaac gaattgcttt cattaggaat 2622181 acgcaatttt gaatatgtga ttgttgccat cggagcaaat attcaagcga gtacgctgac 2622241 caccctatta ttaaaggagc ttgatattcc aaatatttgg gtgaaggctc aaaactatta 2622301 tcatcacaag gtgcttgaaa aaataggcgc tgaccgcatt attcatcctg aaaaagatat 2622361 gggggttaaa atcgcacaaa gcctttcaga cgaaaatgtt ttgaattaca ttgatctatc 2622421 tgatgaatac agtattgtcg agctgctggc tacgcgcaag cttgattcaa aatcgattat 2622481 tgacctgaat gtaagagcaa agtacggctg cacgatcctg gccattaaac atcatggaga 2622541 tatctgtctt tcccccgcgc ctgaagacat cattcgcgag caagattgcc tggtgatcat 2622601 gggccacaaa aaggatatta aacgttttga aaacgaaggg atgtagacaa aggtgacact 2622661 tcaaaaggat aaagtgatca aatgggttcg gtttacaccg cctcaagtgc ttgccattgg 2622721 ttttttcctt accattatca tcggggctgt cctattaatg cttccgattt ccactacgaa 2622781 gccattgtca tggatagatg ccctttttac tgcggcttcc gctacaactg ttacagggct 2622841 tgctgttgtc gataccggca ctcaatttac ggtattcggg caaacagtaa ttatggggct 2622901 gattcagatt ggcgggcttg gatttatgac atttgcggtc ttgatcgtca tgatattagg 2622961 aaaaaaaatc ggcttaaaag aacgaatgct cgtccaggaa gccttaaacc agccgacaat 2623021 cggcggtgtc attggccttg tcaaagtcct gtttctgttt tcgatcagta ttgaattgat 2623081 agcagcactc attttatcca tccggcttgt acctcaatac ggctggtcat ccggcttgtt 2623141 tgcaagtttg tttcacgcaa tatctgcttt taacaatgcc gggttttcgt tgtggcctga 2623201 taatttgatg agctacgttg gcgatcctac agtgaacctc gtgattactt tcttatttat 2623261 tacaggaggg atcggattta cggttctgtt tgatgtgatg aaaaatcggc gttttaaaac 2623321 tttttcttta catacaaagc tcatgcttac aggaacgctg atgttgaatg cgatcgctat 2623381 gcttacggtc tttattttag aatacagcaa ccccggcacg ctcggccacc tgcatatagt 2623441 ggataaactg tgggcctcct attttcaggc agtgacgccg agaaccgcag ggttcaattc 2623501 tctagatttt ggaagcatga gagaaggaac aattgtattt actttattat tgatgtttat 2623561 cggagcagga agcgcatcaa cggcgagcgg cattaagctg actacgttca tcgtgatttt 2623621 aacatctgtt attgcttact tgagaggtaa aaaagaaacg gttattttcc gccgttccat 2623681 caaatatccg attatcatta aagctttagc tgtgagcgtc accagtttgt tcatcgtgtt 2623741 tttagggatt ttcgccctga cgatcacaga acaagcgcca tttcttcaaa ttgtgtttga 2623801 aaccttttcc gcattcggaa ctgtcggcct tacgatgggg cttactcctg aactgacaac 2623861 agctggcaag tgtatcatca ttgtcatcat gtttatcgga agaattggtc ctttaacgtt 2623921 cgtgttttca ttcgcaaaaa cagagcaatc aaatatccgt tatcctgatg gcgaagtgtt 2623981 tacagggtga tatcaaaaaa atccggcgtg cagtcgccgg attttttatg attcgatatg 2624041 agattgattt tgtctttttt cctgttccgc gatgatttcg ttatcctccg cgttatcacg 2624101 ggtcactttt tgcgtaagaa tcgcaccaac tgctacaagt atcataacag cgatgtaata 2624161 acctttttca ttgagttcca gattatcagc attatagagt ccgatactaa acaaaaatac 2624221 tcccgcaaaa aaagtaaaat aagctagtac tgtaaaggca accgtgtttc tgcgtctata 2624281 tttctgcacc tttgttccct cccgaaagca tagttaaaaa gtgataactt ccgtggaata 2624341 ttatacctca aattccccgg aatggaacaa agaattaaaa ataccagtaa aaagggctta 2624401 ggttgcctcc tttatttcaa cagctgaatc atcaatccag ccgataagtt tatcattgat 2624461 ttggaattgg taccatacag actggccttt ctgtttttta gacacaacct ttatgtcttt 2624521 gccgacgtaa gattgggcag aggtaagcct tatggaccga tcatcagtag aaggcttgga 2624581 ccatacgtct tgaacggcac tgtctttaat agaggcgttt aaatccacag atttgaggga 2624641 tggatttacc tcatcgtact catctaaatc gtatttttcc acaatagcgc tgattttgtc 2624701 agcgtagtca gggtctgtag catatcctga tgtttgcagg gcggttgccg cttccttata 2624761 attccctgcc tcaagcaccg gtttatactt ctttttattc cacgatgtgc cacggacgaa 2624821 caattgggcg tgatcatcca tagattcaaa aaacgtgctg tattttcgaa acttcgcgcg 2624881 aatggttttt cttttccctt tttcaacttc gtccgtttcc atcgtgacat gatggccttt 2624941 ataattccct tttacgccaa aaaggttgtt ggccttagca gccagttcac tgttccccca 2625001 gtccgattcg agaatggcct gagcaattgt gatgctgggg agaacatggt atttttcata 2625061 caaaatttgg gcatgtccgg acagactgtc tataaatact tgctgttcat cgatttcttc 2625121 agtttctttg gatatttcaa tcggttttga taaagttgtc gctaaaacaa acagagctag 2625181 cggaatcgat acaaggaaaa atagtgaaat caagagttta cgttttttaa gttttttacg 2625241 ggccatgaaa accttccttc gaattaaaag attacgaatg taaaagaatc taccttttag 2625301 aattttactt gcacttctaa tatttttcaa ttctttaggg ataaagttgg gaaaagattg 2625361 caaaataaaa accttttcgc tcaatgaaaa ggtttttacc atgtttctat ttttgtaaat 2625421 ttctgagtgc attccgatat tccgtatcat ttattacttt atatgatttg acagttgcct 2625481 tcgacaaacc ttgtgctgag acggccggtt tttccggagc tgttttcgct ttatcatgtg 2625541 gtttatgtgc cagcttgtgc cccattccag tggcattcat acaaaatgac aggcagacga 2625601 gcagcacgct aaggataaaa gaaatgaaga agagatcatg ataagcagtc atcatagaat 2625661 cctgtaccga accgctttgt ctggcagcat cttttttcgt gaaaaagccg atgagaatgg 2625721 gaactcccat atagacaaac aatcttaaaa actgaacagc tgtcattctc ttgaccaaat 2625781 caggcagcgg gcctcccatg gcagctccca tcagccctgc ggcgactgtc aggcctgttc 2625841 ccgctgcaag catgataaac agtgccgcga acatataaag agatgatcga tcctgtatat 2625901 gcagccattg aaaattcaca aaaacgagaa tgagtccgcc gataataccg agcatccctg 2625961 gtccgacttt atcgtataac agagcgctca aaatggccgc gatcgccact ccgattaaaa 2626021 gagtcaagct taaaagaatg agatgctcct gagaaatatc atacatttga cggagcaagc 2626081 cttgaaaagc agaaaggctg acagctaccg ttatcgtccc tgcagctatg atcaataagc 2626141 cgagcaccgg ttttggcagc agcatcagtt taatagatat gaaggggttt ttcactttat 2626201 attccacaat caatagacca atgagcaaac ataacgtcac cccgaaacca atccatacat 2626261 aacccgatga cagcccccat ttttgcagaa aaatgaatga aaccgctgag gctgcggcaa 2626321 ggaagacaga taaaagaatt cccgcacgat caagcggctg ttcttgatcc gccgctccgt 2626381 gatgctcatc atgaagaaag aaatagctca ccgcgacacc gatcagggac aaggtgccaa 2626441 agatgaaaaa cagccatctc caatgcccgc agcttgttgc aatggttccc aggattgtac 2626501 cgatgataac agaaccatag aatcccccga tcagcacaag cagtgcatag ttcctgcgtt 2626561 caatcgggaa tgacagtaca agcattggaa tcataatcat cagcatgacg cctgttgccg 2626621 ccccttgtaa aaagcgccct gccgccatca atgcaatatc gcctgaacat gcgatgagca 2626681 gtgagcctag tataaagaca ggtaatgaag ccagatagac gggacgagca ccgaattttt 2626741 tcctcagcag cggtcctgcc ggaactaaca aggcaaaggc catattgccg atcaatatcg 2626801 gatttactga tgtaaagaca cttgttccaa ccgttttctg aacaaggcct tgaactgacg 2626861 acaatgccgt gttagacatc aatcccggcc cgaccgctaa gacggcgagc aaagaaatca 2626921 cccaatagtg ttttgtcttc atgttgtcat cccttcctat atgaatacat gcgaaacaca 2626981 tcattttttg aaaacaaaag aagctaatag attttgcata ccattagctt tcattctaat 2627041 attctccctt tcaggggaaa tgatattatt ttattataat tatgtgaatg aatgagcata 2627101 taatcaaata ttatttcaaa tcgattgtgt tttgtcaatg gagtaaattt caagcacaac 2627161 atagaaagct tgaaagcttt tccccgatat tgtgtctaga actgcactta tgaatccctg 2627221 ctcgttccct caagcgaatt aaagcaggcc gttttaatcc tttcaatcca ctattccaac 2627281 taataaactc aaataagttg gtgataagac aacattttac ccccacattt ttttgtgttc 2627341 actgggcgtt tgccgcctct aaattgtata tgggtaaata ccatgaatta acctatgaaa 2627401 taccaatgta agggaggcaa aaacgaatgg aactgtatga gtgtatccaa gacatttttg 2627461 gcggcttgaa aaatccatcg gttaaagatt tagcaacgtc tttaaaacaa attccaaacg 2627521 cagcaaaatt gagtcaaccg tatattaagg aaccagacca gtacgcttac ggccgaaatg 2627581 ccatctatcg aaataatgaa ttggaaatta tcgtgattaa cattccgcca aacaaggaga 2627641 caacagtaca cgatcatggt caatccattg gttgtgcaat ggtgttagaa ggaaagcttc 2627701 ttaattctat ttatcgttca accggcgaac acgcagaact ctccaattca tactttgtcc 2627761 acgaaggaga atgccttatt tcaaccaaag gtttaattca caaaatgtcc aatccaacat 2627821 ctgaacgaat ggtgtctctt catgtctact cccctccttt ggaagacatg acggtctttg 2627881 aggaacaaaa ggaggtattg gaaaattcat gattgacaga taaactgctc actttgactt 2627941 cactcaactg gaggattcag agaatgaaac cttttcctca aaacaaaaaa acccttatcg 2628001 aataagggtt taaaggtatg gagccaaggg ggctcgaacc cctgacctct acgctgccag 2628061 cgtagcgctc tcccagctga gctatggccc cgtatgtaac gtcatgttta ttatagatga 2628121 ttttattttg aaaaacaagc tgtttcctct tgaattgaca gaaaaaataa ggctcggaaa 2628181 agagccttat ttttcgactt acatcatgat caaaagtaaa atcacaccga gaataattcg 2628241 atagattgca aatgggacaa gtttgatttt gttaatcagc cttaagaaga aacggacgac 2628301 aaacagtgcg accacaaagg cacagataaa gccgacgatg aaaaacggca tcagatccga 2628361 acttaagctg tcccaatgct tcacgaggct tagaaagctg gctcccatca tgatcggcat 2628421 cgccataata aacgtaaagt cggctgcagc tcggtggttt aatccgagaa taacaccgcc 2628481 ggaaatggtt gaacccgaac gcgagaaacc aggccaaagg gaaagacatt ggaataagcc 2628541 gacggctatc gcctgtttat aggaaatgcg gtcgagtgtg tctgtcgctg ttttccgttt 2628601 attgacccag tcagcaaaaa gcatgaggat tgccccggca attaaaccga tggccacagt 2628661 tttaacggaa aataaatatt catcaatgta atcttcaaac aaaaagccga gaacagctgc 2628721 aggcacgagt ccgacggcaa tttgggcaat gcttaattta tgtccctgct cctggtcgct 2628781 tgtaatattt tttttcaagc ccagtaaatt taaaattcgg tctttaaaca cgatagctac 2628841 tgctaaaatg gagcctagct gaataaccac cttgaatgag ttagcagctt cttctgacat 2628901 cagattactt gattttagcc agatgtcgtc tactatgatc atatgtcctg tcgaagaaac 2628961 cggcgcgtac tctgttaatc cttctacgat tcctaaaatg gcggctacaa acaattccca 2629021 tagagtcatg attttgattc tccccattag acatttattt ttttacataa cgggagcttc 2629081 ccataaatgg aaagcccgtc ttatataact ataaacgaaa atcacacttt atgccccggc 2629141 gtattttcat ttttttcttc atcgtataaa tgtgactgca ttttaaacca gtcaaataaa 2629201 tgtgtcgtaa tgactttggc aaccgcatag ccgggaatcg caagaatgat tccaacaacg 2629261 ccaaacagct tgccggctgt taacagcaga aaaataatcg taatcggatg gatgtgaagg 2629321 ttttttccca taatttgcgg agagatcagc ttcccttcaa tcagctgaac aatcgtccaa 2629381 acgatcacca gcttaagcag catgagcggc gatgtcacta tggcaatgat aatcgcaggc 2629441 gtaatggcaa tcgttggccc taaatatgga acgatgcttg tgcaagccgc aatgactgca 2629501 agcaatgaag cataatccag cccgataatc aaataaccga taaacagcaa aaacccgata 2629561 cagaagctga caatgatctg gcctctgata taagagctta accgatgatt catttcgctt 2629621 aagactgtat atgtctgttc tttcaatcga gtcggcacaa acttcagtat gtagaccggt 2629681 aattttcttc cgtcttttag caaataaaat agaataaacg gaaccgtgac gatcgaaatg 2629741 ataatctcag tcagtgcgcc gataaaattc ccaacaccgg taaaggtgct gttcacgatc 2629801 gtcgctgcct gatccgaaac ctttgtagca agatcagata tattaatgtt catcgtttgc 2629861 tgggcctgat tgacgaagtt gctgccaatc agctgtttcg tctgattttc tacgacgtcc 2629921 acatatctcg ggatattgtc aatcaaactc ataatttgtt cttttaagaa gggaatgatc 2629981 gacacgatcg tgatcgtgat cagcccgata accaataggt atagcagcaa tatagaatag 2630041 attcttctta ttcttcttct ctccagaaaa tcgacgactg ggtttaacag ataaaaaaca 2630101 atgcctgtca aaataatcgg aagtgatatc gttttgagca gaacaataat cggggtgaaa 2630161 ataaatgatg tttttgtaaa tactagaata tttaaaccaa tcagcagcag cacaagcaaa 2630221 aataaaacaa acttattatc caagaagaat cgcttgaatc tgccgctcca tgtttgcaac 2630281 gtctccacta tcgttcctcc gtcatacata gtttaattaa attgtacact atcgtcccta 2630341 taatgaaaaa taaaaaccgt taattgctgg aaaagctttc tcggttttaa cattctattt 2630401 atatctatca tgtgattttg ttctttttaa gctataattt agctatatca tgcaaaagga 2630461 gcgatacgag tgatacgttt tgcaataata ggaaccaact ggattacaga ccgctttctt 2630521 gagtcagcag cggatatcga agattttcag ctgactgctg tttattcaag atcggctgaa 2630581 cgcgctggcg agtttgctgc taaacacaac gctgcgcatg ccttctcaga ccttcaggaa 2630641 atggcggcga gcgattgctt tgatgccgta tacatagcga gcccgaacgc tcttcacaag 2630701 gaacaagccg ttctctttat gaaccatggc aagcatgtgc tttgtgagaa gccgtttgct 2630761 tcgaatacaa aagaaacaga agagatgatc tcagcggcta aggcaaacgg cgttgttctc 2630821 atggaagcaa tgaagaccac tttcctgccg aatttcaaag aactgaaaaa acacctgcat 2630881 aaaatcggca ctgtccgcag atttaccgca agctactgcc agtattcctc acgatatgac 2630941 gcgttcagaa gcggaactgt tttgaatgcg tttcagcctg agctttccaa tgggtcatta 2631001 atggatattg gcgtctattg tatttatccg gctgttgtgt tgtttggcgc gccgaaggat 2631061 gtaaaagcaa acggatatgc tttatcctcc ggagtggacg gagaaggaac tgtcattctg 2631121 tcttacgacg ggttcgaagc tgttctgatg cattccaaaa tctctacttc ctatgccccg 2631181 gctgaaatcc agggtgaaga cgggacgatt gtaatcgata cgattcaccg gcctgaacgt 2631241 gttgaaatcc gctaccggga cggccgcctt gaaaacatcg cgatccctga tcctaaaccg 2631301 gcgatgttct atgaagcaga agaatttgtc acgcttataa aagagaataa gctggaatct 2631361 gaagaaaata catttgaacg gtctttgacc accgcaaaaa ttatggaaga agcaagaaag 2631421 caaatgggga ttgtataccc tgctgatcaa gcttaaaaaa atccgcccgc gtgcaaatgc 2631481 cgcggcggat tttttattag acaatcggag aagatgcctt cctttttaaa agcacctgtt 2631541 gctcatattc tttgatgtca taaagccatg cctcttttac cggaacgccc atttgctcac 2631601 agtaggaatc ccagatggct ccgaaaggat atgttttgaa ttcctccatc agggccagcc 2631661 tttctgtata gcggccctct tcctgcaatt gttttaaata tccgttcggg agaagcaggg 2631721 catacaataa agctttgatc atatttctcg ttccgatggt ccaggcggct acacggttaa 2631781 tgctggcatc gaaaaaatcc agaccgatgg ctaccttctc aagagcatga tttcgtacaa 2631841 tttcaagagc gatttctctc aattcatcat ccaaaaccac tacatggtcg ctatcccaac 2631901 gaacaggccg cgatacgtgc aaggcaagct tgtctgtgta aagcagcatg gacgagatct 2631961 tgtttgatac cgtctcagtc ggatggaaat ggcctgtatc aagtaaacaa agcttatgat 2632021 tcgtcaaagc ataagctaaa taaaattcat gagatccgac aacatatgat tcggagccaa 2632081 gcccgaacag cttgctctcg attgaatcaa gattatgttg ttcactgatc tcctctgaga 2632141 agatccgatc cagtgattct tttagtcttt tacgcggtgt cagcctatca ctcgggatat 2632201 ccttatagcc gtcgggaatc caaatattcg tcaagcaagg tgttcctaat tctttcccga 2632261 agtattcccc gatacggcgg caagcgatgc aatgcctgat ccaaaattct ctgatgtccg 2632321 gatcagggtg tgaaagggtg agtccgtcag ccgctttctc atgcgaaaac aaggttggat 2632381 taaaatctaa accgagacca aggttttttg cccatttcac ccagttttca aaatgctgcg 2632441 gcttcaattc gtcacgttct accgcttccc tgtttgtttc tgcgtatatc gcatgcaggt 2632501 ttacgcggtg ctttccagga atgagagaaa gagccttctc caaatctctt cttaattctt 2632561 caggagtttg cgcttttccg ggataattgc cggtcacgtc aattccgcct gaaagctcgc 2632621 ccttatttac ttcaaagcct tcaatgtcgt caccctgcca gcagtggatc gaaatgggca 2632681 cttgctctaa ttgccgaagc gcctcttcaa catcaattcc ccatttttca tatgcctgtt 2632741 ttgcactgtc ataattggct tttatggtca tacggctctc tccctttatc agtttttcaa 2632801 tccaaataaa aaacttcctt tagatctatc gcaacaggac tgaaatccga atttgttttc 2632861 attaatggcg ccatcgattt ccaccatctt tggcaaactt ccgtgtccgc catctttctc 2632921 catttctctt catcctctat ttctaaatat gcaaaaagcc tgcctgtttc ctcgtctaga 2632981 aaaatggaat aatggtgtgc tccatgagct ttgagtgctt ctgccatctc aggccaaatg 2633041 tcatcatgcc gctgtttgta ttcttcgtac ttgtcttgat ggacaaacat gatactggct 2633101 tttcttttca aaccttttca cctcttcatc atttagatag cgctttcaaa acagtttgct 2633161 gaaatgactg aatgatcgtg cttctatcaa tgtctttagg tgtaaacact ttgatcggaa 2633221 aggaatttct gacgacttgc cgggcttctt ttatgtcttt gacttctttg gcagcaatca 2633281 tttgcatcaa aagatttccg gtggcagttg cctctatcgg ccctgcatat accgcttttc 2633341 cactcatgtc tgccgttaat tgatttaaga aatcattccg ggctccgccg ccgatgatat 2633401 gaaattgctc gatcggtttt tctgtgattg tttcgagctc tttgatggct atcgcataga 2633461 tgatggctaa attgctgtag atgcagcagg caagttcgcc tgcagtacgg ggaatctttt 2633521 ggcgggtttg tctgcaataa tgttgtattt cctttatcat gttttctgga ttcaggaaac 2633581 gtttatcatt taagtttata aattgctgga atggttctgt ttttttggct tcttctgcaa 2633641 gctgctgaaa agaataatct gcttgtagct gctgtttgac ttcttgtatc acccacatgc 2633701 cgataatgtt tttgagaaag cgaatggtgt tgtttgcgcc gcgttcattt gtatagttgt 2633761 tttctaaagc aagatcagtt attatcggtg ttttgttttc aaccccgatt aacgaccatg 2633821 ttccgctgct gatatacgcc cagccatcat ttacgcctgg cgccgcaatg acggccgagg 2633881 ccgtatcatg tgttgcgact gtcatcacct tgcacgccgg gagatcataa tccgggaacc 2633941 actcatttct tagcttcccg agttcacacc ccggttcagt gagcggcgca aattgctgtt 2634001 ccagaacaga cacggcttca agcaattcag gatcaagatt tcccgttgag acgtttaaaa 2634061 gctgtgttgt ggacacgttt gtgatttccg ttacagcttt tccggttaaa caatagccta 2634121 aataatcagg aatcatcata attttgtctg tctttttcag cagctcacgg tcttcttcaa 2634181 acaattgata gatcgtgttg aaaggctgaa attgtattcc tgttttttga taaattgcgg 2634241 cttttgagag ggtatgttcc agtttgtcta ttgtgtgatc tgttcttcta tcacggtagg 2634301 agattgcttc ccgcaaccga tcgccttttt cgtccagtaa gacataatcg actgcccatg 2634361 tatcaatgcc tacggtgcag tgttcatacc caagcgtctt tactttttgc agtccttgca 2634421 ggatttgttt tagcaaatga tcaatatccc ataagcaatg cccgtctctt tgactgaaac 2634481 cgttagcgaa cctgtgaatc tcttgtatgt caagcttccc ttcattcagt tcacctacca 2634541 tgattctccc gcttgatgcg cctacatcaa tggcagtata aatcatcctt tcaccctctc 2634601 ttcgaaagag gaacagctgt caccttcacc tttttgtcct caagagcttt taccgatgcc 2634661 ggatcaagtc cagaatccgt aataaggcgg ctgacatctt gcagcgaggc gatatgtgaa 2634721 aactcgcggt tcccccattt gcttgaatcg gccatcaaaa tggtctggtc cgacctttcg 2634781 atcatccgtt ttttgagcag cgcctgccac tcatttgaat cactcatccc gttgtgtacg 2634841 tcaaatccct tacatgacag aaaggtttta ttgacatgat aggtctcaag tgaacgctct 2634901 gctaacgggc cggcaaatga taatgatttt tccagcaaaa tgccgcctgt tgaaatgact 2634961 gatatgtttt ctttattgct gagttcaata gctgctttca ttgagtttgt aatcacggtg 2635021 agctcaatgt cagggagtat ttttgccatg taccaagcgg ttgtgcttgc atcgagaatg 2635081 attcggtctc cgctttttac atatttggcc gcttcgtgag cgatggcttt tttttcgatg 2635141 acattcgtga tttcccgttc agaaaaatga atttctgatt ccttctgctg aatactgacc 2635201 gctcctccgt ggctccggct cagtttatgt tctttttcaa gcttttcaag atcacgccga 2635261 atggtttcct ctgtgactga aaaaatgtca cttaattcgg aaacgcggat gcttgaacgc 2635321 atatttacta tttccactat tttttgctgc cgttctgcta ctagcatcgg taacgccctt 2635381 cctcatatcg tagtccgtct tatattttta tcatagcata tatctaacgc gtaaaagcag 2635441 cagggacgcc gccgtctacc gtgatcatgc agcccgttgt tttttcggct ttggaagaag 2635501 cgaagaatgc aatggcttcg gcaatatcct ccgggtaaat attgacgagc aatgctgtcc 2635561 gtttccggta atgttcctcc agctgatccg gttcaatccc gtacgccgcg gctcgttcct 2635621 cacgccagct tgaaccccag attgccgatc cttgaagaac tgcatcaggc aaaacggagt 2635681 tgaccctaat gccgaattct ccgccttctg ctgcgatgca tcttgctaaa tgggtttcaa 2635741 gcgccttaac agagctgtag gcagaggcgt tttttcccgc ataaactgaa tttttcgatc 2635801 cgacaaatac catgcttccg cctctatttt gatgtttcat ctgtttaaac gcttcacggg 2635861 ctacaaggaa atagcctgtt cctaaaacat tcatattaag attccattct tttagacttg 2635921 tttcgtcaaa tgggcttgat gtggccagcc cggcattatt gacgacgata tcaatgccgc 2635981 cgtaagcaag cgccgctcgt tcaaaagctg actgtacgtc ttcctccttt gtcacatcca 2636041 ttttgacagc cattgcccgt ccttttccgt atgcatcgtt tatttccccg gcaattttct 2636101 gtgcgccttc tatattcaga tcagctacga tcacgtgccc tccctcagct gcaaatcggc 2636161 ggcatgccgc actgccgatt ccgccggctc ctccagttat cagcgctact tttcgggaaa 2636221 attctgcttc cggcggggcc agcgtgagtt tatatagttc gagcggccaa tattcgacat 2636281 ggtaggactc attttcatgt aaagaaacaa attgccccag agcggttgct cctttcatta 2636341 cggcgatggc cctccgatat aaagccccgc ttactttaga catcgcataa ctttttcctg 2636401 tattcaccat tccgattcca ggaatcaata tcacccgcgg ggcggattca aagatttgat 2636461 ccccatcctg ctgattgcgt gtaaagtaag cctgatactc tgatgtaaag gtctcgactc 2636521 ctgacttgat cagatctgca agcttgtgca catcttgagt ttccggattc caatcaatgt 2636581 acagcggaac ccgttttgtg tgaacaaggt gatccgggca tgccgcaccg atttgcgaaa 2636641 gtgctggcgc ttggacactg tttacaaatt ccaagacatc gtcatgatca tcataggaaa 2636701 ggatcatttt cttttcttca cttactgctc ctctgatcac aggcatgatg cctgccaaga 2636761 tttgttttct tttatcctcc ggcagcggct gatacctttt gcctccgaat acctcatgct 2636821 gattgatacg atcgttaata tactgctcgg cttcttgaat gatggatatc gttttttgat 2636881 aacatgtttc agacgtctct ccccaagtga ctaagccgtg tttctccatt aatacaagct 2636941 cggcgtgggg gttgtttgct acgccttcag cgatcatttt agacaaagta aatccaggac 2637001 ggacgtatgg cacccataca aaccgatttc cgtaaatgtc ttcagcgatt tgttttccat 2637061 tatccgcaca gcatatgctg ataatcgcat ctggatgggt atggtcaaca tgtttgtatg 2637121 gcagaaaagc gtgtaatagc gtttcaattg aagggcgggg atgtttgctg tctatcatac 2637181 aatgagacag gtagtctacc atttcttcat cgggcatttg gtccctttta atcagcgggc 2637241 ggatatcatc taatttcaaa ccggaaaagt tatgcgcttt cattgttgcc aaatccgatc 2637301 cgcttccttt tacccacatg acttctattt cacggcctct aaaatccttt tccgttgttt 2637361 tcatagatgt attccccccg ccccagttgc agacagtgcg gtctgacccg atcagattgg 2637421 acctgtacac caattcctct acacctttag gtagctgtgc agctcgctct gaatcccata 2637481 tatgtttcac catatttgat attcctccat acccttttat ttgtatccgt tttcattata 2637541 tatgatttct gtttgttttt gaatcgtttt tgtttatttt tgctttttaa caaaaaaaga 2637601 aagcagcaga tatgccgctt tctcgtttca ttatgattct attttaaatt tcttcgtaat 2637661 gtcctgaagt tcttccgcca tgtttgccaa cgtttccgct gaagagctga tttcttccat 2637721 ggacgcaagc tgttcttccg ccgaagctgc gatatcctga atgcctgctg agctttcttt 2637781 cgccactgca gaaatatctt caacagcact tgacacttcc tgtgatccgg ctgacagttg 2637841 ttcaaccgtc gcgttcaagt tttgcaattc gccggaaatt tgggttgtca tctcatagat 2637901 ttgtttaaag ctttccgctg tttgatccgt aatctgcaag ccttctttca cttcatgatt 2637961 cacggattgg aacattgaaa gtgaggtgct gatttccctg acaatctctt gaattaatcc 2638021 ttcaatttcc ttggcggagt ctgctgattg tacagcaagt tttctaacct cttccgcaac 2638081 tactgagaaa cctcttccgt attctcccgc tcttgccgcc tcaatcgcag catttaatgc 2638141 aagcaggttg gtttgatcag caatgccgtt aatcacattc aagatgcttg tgatgtcttg 2638201 cgattttgtt tcaaggccct tcacaaccgc ttccgctttt tgaacggatt ggtcaattgt 2638261 tttcatctgg ccgactgtat gctccaccag cttttctccg ctgcccgctg cctcagagga 2638321 ctgaatcgat gatttcgtaa tggttgaaga ggcttgagcc acttttgaaa tcccctcgtt 2638381 catttgagaa agatgatttg agcttgtttc cagtttctcg ctttgtgcct cgttgccatc 2638441 tgagaactgt tcgatggcaa gtgtaatatg ttcagttgcc ttgcttgttt gggctgcgct 2638501 tgctgtcagc tcctcagaag atgaagcgac gttttctaca gacgtttgaa taacgcctat 2638561 tacagaacgc aatgatgcag acatttcatt aaagctttcg ccaagctggc caaactcgtt 2638621 tttcgagtga atgtcaatga cttctgtgag atctccgctg ctgatttttg cagacgttga 2638681 gacaagtttt cttaacggct tggtgatggc acggataata tagagtatga gtatgccgcc 2638741 gattactatt gacacgcata gaatgataac cgcagtgttc agcaccgggc ttgaagcatc 2638801 ttgcaattca ctgacaaaat atgtgcccgc gattttccag ccagtcagtt tatttgtcgt 2638861 aaaggccatt ttcttttctt tgccttcgaa tgtatattca aatgagcctt cttttttgga 2638921 atatacttgg tttgtccaat cgccggaacc ggttgtcccc ggcttaatgg tcggatgggc 2638981 gatatatttt ttgttgcctg tcgtaataaa tgcaaagcct tcttttccga ttttgattct 2639041 ttttgatgca gtaagcactt catccaggtt taaatctagc gctataaccc ctgaaccgtc 2639101 ttttaattgt tttgaaattg tgacaacgat atctcctgtc gcttcatcgg tatacggttc 2639161 tgagaaaaca gcttgtcctt tttccgcaac cgcctgtttg taccagtcac gtcctgtcgg 2639221 atcgaaacct ttcggaacac cgctatccgg atatttataa agcttcttat cttctgaggc 2639281 agcatagatt gcgcctacat cgtcgttaag tgtcgtgtac tgcttaaatt tctctttcag 2639341 taatgttttg tttttgccta acaatatgtc tttatcgact gtctcactat aataatctat 2639401 tgcttttact ttatcttcta atttattttg cagcgtactg tttagttctt caacatttcc 2639461 cttcgcactg cttatgagct ctctgtctaa cgcgttccaa gctgattgat aactgaaata 2639521 tgctaaaacc ccaaccggca aaataagcac tgccagaaac gcagcgatta gcggtttgct 2639581 gatcgatggc tgtttgatcc attgtatgaa ttttcccatt ctcgttgact cctcctttaa 2639641 gataaatcta atatcgtcaa actaggataa aaggtttaat aaaaaaacta aaaaaaacac 2639701 ccaagcgcaa caagcttggg tgttaaggct tattattcaa ttttaaatcg tttggtcata 2639761 tcccgaagct cttccgccat agaggaaagg gtctctgcag acgagctgat ttcttccatg 2639821 gaagctagct gctcttcagc tgacgccgcg atatcttgta tatgcgctga gctttctttt 2639881 gaaatcgatg caatgtgctc agacgctccc gaaacttctt cggagctggc agaaagctgc 2639941 tgaaccgtcg cactcatatt ttgcagttcg ccggcgattt ggttcgtcat ttcagaaatg 2640001 cgtttgaagc tcatttctgt tttatctgtg atgtcaagtc ctgtctgcac ctcttgattg 2640061 acagattgga acatgccgag tgatgtattg atttccttca caatttcgat gattaatcct 2640121 tcaatctctt ttgctgaatc tgctgactgt actgccagtt ttcttacttc ttccgctaca 2640181 acggagaagc cgcggccgta ctcgcctgcg cgcgctgctt caattgctgc gtttaaggca 2640241 agcaggttcg tctggtctgc gatgccgttg atcacacgca aaatgtttgt aatatctttc 2640301 gatttcgttt ccaatccgcg tacgacttgc tccgcttctt taacggactt gtcaatgaca 2640361 ttcatttggc cgacggtttg atgaacaagc ttgccgcctt cacttgcaat ttctgtcgat 2640421 tgaacagatg aatcagtgat cacttcagaa gcttgagcca tattcgtcaa cccgtcattc 2640481 atttgataaa tgtgctctgc tgccgtttca atgttttcgt tttgtttttc attgccgtta 2640541 gaaaattgtt caatcgccaa tgtaatgtgc tctgttgcct tgctcgtttg cgcagctgat 2640601 gcagtcagct cctcagagga agcggcaaca ttgtctaccg aatcctggat ggcgtgtatg 2640661 agagaacgaa gtgacgacgc catattgtta aagcttttgc cgagctcgcc caattcatct 2640721 tttgaacgga tatcaatggt ttccgtcaaa tctccctcgc tgatccgctt agaggaaccg 2640781 acaagctgtt tcagcggtgt tgtaatcgac cgaatgatca atgtcatgac gataatccct 2640841 atgataatag ctgcggccaa gacaattaaa gcaaggtgaa ggacaggctg ggctgcctca 2640901 tggatttcat ccaaatacat ggtgccgccg atcttccatc ccgtcaactt gtttgtgtca 2640961 aaggccattt ttttcttatc gccatccatg gtgtattgaa aatcgccttt atcagcactc 2641021 aacatcttat cgagccagtc gccttttaat tcagttcctg attgttcatt agggtgtgcg 2641081 acaacttttt tgtccttcgt catgataaat gcgtagcctt gtgtgccgat gttgactttt 2641141 ttggttgttt tcagcagatt ttcaatcgtc atgttgattg cgataacgcc tgaaccatct 2641201 tttgtctgct gggcgattgt cacaaccatc gtatttgtcg acgcggtttt ataagggtct 2641261 gtgatcacga ctttcccttt atttgcaacc gcttttttgt accagtcgcg ttcaaccgga 2641321 ttatagccgc ttggcatcgg aagatccgga tagcgggtaa agtgcccttt tgtgtcactt 2641381 gtataaatgg attctacatc cttgttaatg ctgatatatt gtgagaattt ctctgcaatg 2641441 cttgcattgc tttttgcatt gtatttctct tttgtcagcc attcgctgaa ataatcagca 2641501 ctgttttctt tttcgccgat gctggtgtta atgatttcgt ttaattgctg tacattttcc 2641561 aatgcgctcc ccatcatctg tctgtcgagt gagctgctag ccgattgata cgcaaagatc 2641621 gccaatatga caaccggtat gatgaggatc gacagaaagg aaacgagaag cttccgtgta 2641681 attgatcttt gttttatgag ttggagtatt tttttcatca ttcatttctc cttttttatg 2641741 ctacccttca tatcggctgg aaatgggtaa atatatacag caaaaaagaa gaaatttaac 2641801 aaaagtaact aatttcccat aaataaatag tattttagac ctattatttg tctactttaa 2641861 attgttttgt cagatcacgg agttcttcag acattctttc aagcgtcagt gcagatgaac 2641921 taatctcctc catggatgcc agctgttcct cagctgaagc ggcgatatct tggatgccat 2641981 ccgagctttc cttagaaatg gcagtgatat catttgaagc tgcggaaatt tcttgagctc 2642041 ccgctgacag ctcctcaacc gtcgcattca tgttttgcag ctcggaagca atttgattgg 2642101 tcatttgcga tatatgtttg aagctctgtt tagtttcatc cgtcatgaca agccctgttt 2642161 caacttcttt gtttacggac tgaagcacgt tcagtgatgt gtgaatttct tttactattt 2642221 cactgatcag cgattcaatt tcttttgctg agtcagccga ctgtaccgcg agctttctca 2642281 cttcctcagc gacgactgag aagccccggc cgtattcacc cgctctggca gcttcaatgg 2642341 cggcatttaa agccaaaaga ttggtttgat ccgcaatgcc gttgatgaca cgcaaaatat 2642401 tcgtgatatc ctttgatttg atctccagcc ctttcaccac ttgttccgct gcttttacgg 2642461 aatggtcaat tgtgttcatt tggccggctg ttttctggac gagtgtctcc cctttgcttg 2642521 acacttcggt tgaatctgcg gatgtttctg taatcactgc tgcagcccgc gccagctctg 2642581 ccaatccgtc attcatttca ttaatttgtt cggttgtcgt ttctattttc tcgctttggc 2642641 tttcactgcc gtttgaaaat tgctcgatag ccatcgtaat gtgctcagtg gctctgcttg 2642701 tctggtctgc cgatgcagtc agctcttcag acgaggaggc aacgtgttct actgagtctt 2642761 tgatcccgtg aatgagcgag cgaagcgagt gtgccatatg attgaagctc tcactcagaa 2642821 cgccgagttc atcttttgaa ttgatttcaa tcgtttcggt tagatcgcct tcactaattt 2642881 tttcagcgga tgcgacaatg cgtctcaatg gctttgtgat ggatcgaatc acaaaataaa 2642941 tcgccgtcat tccagctccg atggcaatcg ccagaacgat tgaagccatg atcagaaccc 2643001 tgcttgcagc atcgtgaatc tcgtttgcat acatcgtgcc gctgattttc cagcctgttg 2643061 tttggcttgt tgcaaatgcc atttttttct ttttgccttt gtacgtatat tcaaagtccc 2643121 cgcttttatc cttgtagagc ttatcaaccc agtccccttt tagctctgtt cccgcttttt 2643181 ctccggagta ggcgatgact ttcttgtttt ggctcaaaat aaaagcatag ccttcttttc 2643241 cgatattgat tcctttcgcg gtagtgacta agtcatcaat tttcatatca atggcgacaa 2643301 cgcctgaccc atccaccgtt tgacgggcga tggtgacgac catttttcct gatgaaatcg 2643361 attcataagg ctcagtgaca attgttttgc ctttattggc cattgcttct ttgtaccaat 2643421 ctcgttccaa agcattaaag tcgcttggca tgtcagcgta cggataacgt gtgaagtccc 2643481 cgtctttgcc gcttgaaaat accgcagcga cattatcatt catttggata aattgtttaa 2643541 attcctgttt cagctctgtt ttctttttat cctgaaattt ttctgctgta gcccaatcgc 2643601 tgaaatatgc gaggcttttt tcagtagtgc tgattttatc atcaatgatg tgatctaata 2643661 tctgaacatt ttcctttgcg ctttgcgtca tctgtacatc aagtgaggca actgctgatt 2643721 gataagcgct aaccgaaagg gcggttatcg gaacaattaa gatcagcagg aaagaaataa 2643781 taagtctcct tgcaattgat gatctgcgaa tagtggtgag tgtttttttc atttcctttt 2643841 gaaccttctt tcaataattt acaaattata tcggcggatc ttcctttaaa ttacattgaa 2643901 aatggaggaa aaaatgaaaa atagttctaa attcacctgt taaactagga ctttattatt 2643961 gtttaccata taaaaaaaca gcgctttgat agcgctgttt ttcggttttt actcgatttt 2644021 aaattgtttc gtcagatcgc gaagctcttc tgccatctgc gcaagagtcg tcgctgagga 2644081 actgatttct tccatggaag caagctgttc ttcagctgat gcggcaatgt cctggatgct 2644141 tgccgagctt tctttcgaca cgtctgcaat gccgctgact gctgctgaaa catgctgtga 2644201 acggtctgac agctgctcga cggtggaatt catcgtctgc agcttgcccg cgatttcgtt 2644261 tgtcatgctg aaaatgctct ggaagctttc ttttgtattg tctgtgacaa caagtccgga 2644321 ctgtacttcc tgattgacct ctttaaacat gtgaagagag gtgtcgattt ctgcgacgat 2644381 ttcttggatc agcttttcga tttctttcgc tgaatcggct gattggacag ccagcttgcg 2644441 cacctcctcc gctacgacag agaagccgcg tcctgactct ccggcacgcg ccgcttcaat 2644501 ggctgcattt agtgcaagca gatttgtttg gtcagcgatt ccgttgatga ctctcaaaat 2644561 gcttgtgatg tcttttgatt ttccttctaa gcctttgaca acagcttcag cctgctgaac 2644621 agattgatta atcgagttca tttgtccgac tgtctgctgc acaaacttct cacccgttcc 2644681 ggcgatttcc gttgattgga tagatgcctt tgtaatatct gacgatgttt gtgagacttg 2644741 ctggagtcct tcattcatta agttcagctg atgagagctg gattcaacct tttcgctttg 2644801 ctcctcgttt ccgtttgaga actgctcaat cgccatcgta atatgctcgg tggctttact 2644861 cgtctgcccg gcagatgcgg taagctgttc ggaagatgcg gccacattgt tcaccgagtc 2644921 ctgaatagcg ctgatcagag agcggagaga ttgtcccatt tcattgaagc tttccccaag 2644981 ctctccaagc tcatcctttg aatggatttc gatcgtttcg gtcagatccc ccctgctgat 2645041 cgttttcgat gattgaacaa gacgttttaa cggttttgta atcgaacgaa cgataaacag 2645101 aattaaaatt ccgcctgcca caatggaagc aatcagcaca atcattcctg ttgtcagcac 2645161 agactttgag gcatccttaa tttcatccat atacattgtg ccggctattt tccaaccagt 2645221 cagttcgttt gtagtatagg tcatcttttt atcttcgtta ttaagagtat actggagttc 2645281 accgctgtca ttcgcataca ttttggctac ccagtcgcct gaaagctttt ctccagcctt 2645341 atggttcttg tgggcgacat aggttttgtt ttttgttgca atgaaagcat aaccttcttt 2645401 tccgaccttg atttgtttca tttgttctaa caatttatca atggtaatat ccatggcgac 2645461 aacgccagat ccgtccttca gctcctgtgc aatggtaatg accatgcttc cgtcactcgc 2645521 agccacgtaa ggatctgtca cgacaatttc accgccggcc ttcatcgcat cctggtacca 2645581 aggccgttgt ctcgggtcgt atccttccgg caatttttct tttggcgctt gtacataagt 2645641 gccgttatct gcgcccccat aaattctggc tactccttga ttaatagata catattgtga 2645701 aaatttagct ttgatctctt cttgatttga tttccctttg aatgcggatc ttttaagaga 2645761 ttcactgaaa aaggtgactg ctttcgcttt ttctcccaga tcatttgtaa cagttgtatt 2645821 aaatgtatcg acactgtttt tcgcatttcc cataatttcc tgatccagct ttccgctggc 2645881 gcttcggtaa gagctaaatt ctaatataag aatagggata atgagaatcg caataaatga 2645941 gacgattaat ttctttgaaa tagacggttt cttcagccaa ttgataaaag tcttcatgtc 2646001 acttgctcct tcaggtttga tacagtatat atcggctgct taaaaaagtt ttaaaataaa 2646061 aaatggaaga agttcttttt ggctgtcttc tgccttttta actttcattg cccaagctct 2646121 ttgcatatct tataaaaaac aaggggggct aaacatgatt attgtatcag gacaattgct 2646181 ccgtccccag gatattgaaa attggcagat tgatcaagat ctgaatccgc tcttaaaaga 2646241 gatgattgag acgcctgttc agtttgatta tcattcaatt gctgaactga tgtttgagct 2646301 taaactgcgg atgaatattg tagcagcggc aaagacgctg cacaaaagcg gggcgaagtt 2646361 tgccactttt ttaaaaacat acgggaatac aacgtattgg agggtttcac cggagggcgc 2646421 cttggagctg aaatacagaa tgccgccttc aaaagcgatt cgggacattg cagagaacgg 2646481 cccgttttat gcgtttgaat gcgcaaccgc aatcgttatc atttattact tggccttaat 2646541 cgatacaatc ggagaagata aattcaatgc cagctttgac agaattattt tatatgactg 2646601 gcattatgag aaattgccga tatatacgga aacaggacac cactttttcc ttggagattg 2646661 tttgtatttt aagaatcctg aatttgatcc gcaaaaggcg caatggagag gcgaaaatgt 2646721 gatactactg ggggaagata aatattttgc ccatggtctt ggaatcttaa acggaaagca 2646781 aattattgat aagctgaatt cttttaggaa aaaaggagcc ttacagtcag cctaccttct 2646841 gtctcaggcg accagactgg atgttccgtc tcttttccgc atcgtccgct aaaaagcccc 2646901 atcgcctatt ttccggacga tggggtttca aatgcctttc gttttcgata gaagggggct 2646961 gtgccaaaat attggttcgc agcccactcc attttttcaa ggtcatttct tgtcacgatt 2647021 ggatcctggc tgctccattt gataaagcgg acaaaatagt agcctttgat aggaaccatt 2647081 gtaacttttg agtgaggcca gccttcaaat acaaactcaa ttttccctct ttttttataa 2647141 gaatattgaa gaatgttcat atctgtcacc tcagtttatc aagttacgtt cggcaaagct 2647201 cggtacgttt acatccattg attaactatc cctcatgcag gctttccgga aaacaaaggg 2647261 tgaggcgcgt gtctctttcc ctcgcttttt atttcgcata tggacgaatg ccaagcacgc 2647321 cttcattcga taaagccgca gcgtgggcgg gtgtgacaag ccctccggct atcggcgctt 2647381 gttcagcgat catgcttttg tcataaaaaa cagcctatta tcccatcatt ttgatatagc 2647441 atgtccgggt gcgaggcccg tcaaattcgc agaaataaat gccctgccac gttccaagaa 2647501 taagccggcc gttttccaca atgacatgct gtgaagctcc gaccgtactc gacttcatgt 2647561 gtgcagctgt attgccctcc atatggcggt ccagctcatg ttcccacgga tatacctcat 2647621 caaaccttct gagcatatct tttttgacgt ccggatcggc attttcatta attgtaatgc 2647681 ccgcagtcgt atgcggacag taaatcagcg ctgcgccgct cgttatacct gtttcttgaa 2647741 gaaacgcttc cacctcccgg gtgatatcta tcatttcatc tcgtttggtt gttttgattt 2647801 gcagtgtttt cagcatttgt ttctcctttc gtttgtccgc tctcatcgct taattcgttc 2647861 tgtgttcttt tttttcctgt taaaccgctc tcataaaccc gataaaacaa aaaaactcca 2647921 gtctaaggct ggagtttagc accatagata tattcttgct tcatacggct ttaagagtac 2647981 tgatgtcata tgcttgtgcg gctctgtttc aatatttgac aagacgagtg catctgatga 2648041 caatggcaat ccagagtgcc tgaacaacgc cggtgttcct gtcagattgg ccgcaatcag 2648101 tgcagtatgg ctctcgtttt tccgaagata tgcaaagatt tgctgatctt ccggtaaaat 2648161 gagctcgtat gtcccgttaa taaaaacatc atatgtttgg cgcagcttga tcaagctttt 2648221 gtaaaaatgg taaacggatg ttttatcgtt tttttgcgcc tcggcattca gccatttgta 2648281 attctcattg attccgatcc acggtttggc ctcagaaaat ccggcgtatg gaccagcatt 2648341 ccattgcatc ggcgttcgcg aattgtctct tccctttttc cagacaatct tcatcacatc 2648401 ctcgtgtgat gtgcctttcg ctgtttttgt ttcatacagg cgtttcaatg cgacatcatc 2648461 atagtcctca atagatggaa aagccacgtt cgtcatcccg agttcctgtc cctgataaat 2648521 aaacggtgtg cctttcatga gaaaataaac agcggaaagc gcttttgcac tttctttcag 2648581 gtacactccg tcgtctcccc acacagaaac tgaacggggc tggtcgtgat tctccataaa 2648641 caaagcattc cagccgatcc cttccagact gtcctgccag tcagttaaaa ttcgtttaaa 2648701 tgcaacgata tcaatacttt cattgatctc tacatcccac aggccgagat gctcaaattg 2648761 aaaaatcatg ctgaatatgc cgtttttttc tccagcccaa tcagctgctt cttttgcagc 2648821 gacgccgttt gcttcaccaa ctgtcataat cggatagcgg gaaaatgtgt tttccttcag 2648881 ctctgttaac aaatccataa tgccgtcagc attcatatga taaggaaagg aagggacata 2648941 gtccagtccc tttggattcg gcatgtcagg aaacccttct tttttcttaa tatgcgtaat 2649001 ggcatccacc cgaaatccgt caattccttt atcaagccac caattgatca tgtcataaac 2649061 ggcattcctc accttttcat tttcccaatt caaatcaggc tgttttttat caaaaaggtg 2649121 cagataatac tggcttgtct tttgatcata ctcccaagcc ggcccgccga aaatgctttc 2649181 ccaattgttg ggcgtttttc cgtttttgcc gtctttccaa atataccagt cgcgcttttc 2649241 cgagtgtatg gatgaacggg attctatgaa ccatggatgt tcgtcgcttg tgtggttcac 2649301 aacgagatcc ataatcagct tcatatccag atcatgaatg tcaccaagca gctcatcaaa 2649361 atcttccatc gtgccaaact cgcttaatat gttttgataa tccctgatat catagccatt 2649421 atcggcattc ggtgaatcat acagcgggca aatccatatg acgtcagcgc ccagctcttt 2649481 tatgtaagaa agcttggttc tgattccttg aatatccccg attccgtcgc catttgaatc 2649541 tttaaaactg cgggggtaaa tttggtaaac tacggcttcc ttccaccaag cctttttcat 2649601 acagccactc cttcccagtg taccgttctt atatatccta tgtagaaaaa ggtctttaca 2649661 gcattgcttt ttaagaaatg acttgatgac acaaaaaaca gccgtttgtt ccccggctgt 2649721 tttttatcaa aaatcagttt tttttatttc tacaaaacgg atgtggtgat cttcggcgtc 2649781 gaggatttta aattcacagc cctccgcgtg tatcacatcc cctgctttca gctccatttt 2649841 ttgcgttaga agccagcctg caatcgtatc aatttcttca ttttcaatcg caatgtcgag 2649901 aaggtcattc acttcgtcta ttagcgcttt tccatccatc acataatggt gctcgccctt 2649961 tttcaggatg tgcggtgttt catcctgatc atactcatcg cggatttccc cgacgatttc 2650021 ctcgataata tcctctacag tgacaagccc cgccgttccc ccgtattcat cgacaagaat 2650081 cgccatgtga atccgctcct tctgcatgcg gattaaaagc tgctgaacag gaatgctttc 2650141 aatgactctg ataacgggcc tcatgatttg attcagcttt atcggctggc cgagaaaata 2650201 agctttaaac atatctttgc tgttgatgat ccctaaaata tgatccttgt catctttgat 2650261 gacagggtag cgtgtatacc gttcattaat gatgtgatga attgcctctt caagcgactg 2650321 ctccagagag ataaccgcaa tttctgtccg cggaatcata atctctctcg ctacccggtt 2650381 gtcaaattca aaaatcttat ttacatagcg gaattcagac tgattgattt ctcccttttc 2650441 atagctttca gaaaggatca gccttagttc ctcttcgctg atgacaacct gatgctcctt 2650501 taccgaatga aagccaaaca atttcacaag aaaacttgca gagccgttta atgctttaat 2650561 aaacgggtac gtgattttat aaaaccagat cagcggcttt gcaatccata agcttacagc 2650621 ttcagctttt tgaatagaaa ccgttttcgg ggcaagctcc cccatcacca catgcaaaaa 2650681 agtgacgatg ataaatgcaa ctacaaatgt gacaatgtgg ttaaacggtt ccggtatgcc 2650741 tgtcattgta aataagggat gaagaaaacg ttcaaatgta ggttcaccaa gccacccaag 2650801 gccgagggct gtaatcgtaa tcccgagctg gcaggctgat aaatactcgt caagattgga 2650861 gatgatttta tgtgcggcta gtgctcggct gtcaccgctt tcgatgagct gattgatttt 2650921 tgaacctctg attttgacga tcgcaaattc cgctgcaacg aaaacagccg taatgccaat 2650981 caaaacaaaa atggcgatca attgtaaaat aagcaaaaaa agcccttacc ataaatggta 2651041 aggggccacc tccttaacgt taattctcat cacgaccgtt taagaaaatc atcacaaaac 2651101 gaagtagttc aaacagggaa accagggcgg cggccacata cgttaaggca gcagcactca 2651161 gcactttatt taccccattt tcttcattgt ttcggatgaa tccttctgac acaataatct 2651221 gcttcgcacg tgaacttgca ttgaattcga caggcaatgt aatcagctgg aaaaagacag 2651281 ccgctgaaaa cagtatgatg ccaagcccga tcaaattcag gctgccgaga agcatgcctc 2651341 ctaagaaaag caaaggagct acaccggatg caaaattcac gactgggaag attttatgtc 2651401 tcagcacaag cgcaccatat gactcctgat gctgcaaggc atgtccgact tcatgggaag 2651461 ctacggatat ggcggaaatt gagcggccgt aatagaccgg ctcagataaa cgcaccaccc 2651521 gtcttgtcgg gtcgtaatgg tctgttaaag tgcctcttac cggttcgacc ggcacgtcgt 2651581 aaagaccgtt tatatctaaa atccgtcttg ccgtttctgc ccctgtacgt ccgcttgagg 2651641 cttccacttt tgaatatttt tcaaagttgc tctttacttt aaattgtgcc caaaacgaca 2651701 atcccaatgc ggctattgtt aaaaatataa acagcatttt ttcatcatcc tttgttcatg 2651761 atcatttctc tattacgatt attttaatga gttttctttc tcgtgtacag aaatgcgctt 2651821 tttcttccgg cttggagcac acaatccaat cagcaaaaag aacaggcctg ctgaaaacaa 2651881 ataaaaggcg aaactgccgg ccagttcttt cagaaaatga agccaggaga agcttccgga 2651941 aaagtgatta tatgaattca aatcgaaaat aaacaaaatc accgcggatg ccgccagctg 2652001 cgtaccgatt aaaaccacga tcgttctttg aaagatcgtc atctttttca tcctttttgt 2652061 tttagtttat ggagaaatcc ggttttatat gttttgtaca ttttttgaaa aacatcaccg 2652121 gaagtgggac atactgttag aaaaaagcac gggtgtgatg gaagctatga aagtgacgag 2652181 tgaggaaaag gaacagctga gcacagcaat cgaccgaatg aatgaaggac tggacgcgtt 2652241 tatccagctg tataatgaat cggaaattga tgaaccgctt attcagcttg atgatgatac 2652301 agccgagtta atgaagcagg cccgagatat gtacggccag gaaaagctaa atgagaaatt 2652361 aaatacaatt attaaacaga ttttatccat ctcagtatct gaagaaggag aaaaagaatg 2652421 aaatcaaatc ggatatttat ttcatggctc aggtggccgt tatttatccg aatcggggtt 2652481 attattttat gtctgattct tttgttcggc caaatcattt atatacttga gcctaagcag 2652541 ttcacttcgg tattcgaagg tatttggtgg gctgtcgtta cggtttctac agtcggttat 2652601 ggagactatg tgccgcacac tccgctggga caggcagccg gaatactgct gattttgagc 2652661 ggagcaagct ttgtcacagc gtatttcgct acgttatcag cggccgcatt cagcagacag 2652721 catcgctaca ttgaaggaaa agttgcttac aaaggccggg accacatcat tctgatcggg 2652781 tggaatgaaa aaacaaaccg gcttttgaag gaccttcagc ttgccgcccc ttccaaaaca 2652841 gtcgtactaa tcgatgaatc cttaacagaa ggcccgctta ttgaaaacgt tcatttcata 2652901 cgcgggcacg ctgccgatga tgggacactg aaacgggcca atattactga agcggaatca 2652961 gtgatgatta ctgccgatca gtataaaagt gaaactgatg ctgatatgct gtcagtgctg 2653021 actcttttat ctgttaaagg tcttaatccc cttgcttact gcatcgtcga gattttaact 2653081 gaccgttttg tcaccaatgc ggaacgggca ggcgcaaacc aaatcatcgg aacttcagaa 2653141 tttatcagcc gggcgatgct gcagcattac caagtcaagt tacggccgtc taaacagcag 2653201 aacggaatca agctgacact tgatcagcat gtggagcttc ttgctgttcc tgacgaacta 2653261 aagggagcgg cttacaaaac ctgtgttctc tatttccttg atcacaacac aacaattata 2653321 ggcatacaaa aaaaggaggg gccgatgctt tcccctcctc ttacatacaa ggtgctcgaa 2653381 acagatcaat tccttgccat ctagtgtaac agaacatcct ccaattcttt cacgagagag 2653441 gcgccgatat ccaaaaatgc cggatcaatt tccgcgtccc gcctttccgg ttcggaaaat 2653501 tgattaaaca gtgattggaa aggccctccc tcggcgtgat cgtcaacatc cgcctgaaac 2653561 acctgtctca gcataaatgg cgttccgatc cggacggccg cccctcgttc atcgagactg 2653621 ccctgtaccg cattgacggg aattcttaaa aataaatagc cgtctctatc atcaatttta 2653681 taatcaaagt agccatgatc gtattcccag ccgccgttta tcacataacc gagcggcttc 2653741 atcacttgtt ccagttcttg aagcagaaaa gactgcccat ctatcgcgga aggtattggt 2653801 atcatcagaa tgcccctttt ttcacttatc ctgtcccgcc gaacaagact tcattcagag 2653861 gcgcctacat ggaaatcgtt gtttctttcg cgcggccaac aggaaagaaa gcgcattcaa 2653921 ttaagaagta aacagccatt gccgctgcaa gccatacagc tgaatcccaa gacacataaa 2653981 caaccgttgc atagagtcct aatttagtga aaagagtatg ggttcgtttt aaatgcaaaa 2654041 tccgatgtac cgcatcggta aaaagggcaa gcggcaaacc aatgagaaga aaggagtgga 2654101 tgaaaaaatg tgacagcgtg ccgccaaagc ttgaagaaaa ccctgtatac acggcatcaa 2654161 aggagataag gaaacttaaa atagctgcag aaaaaccggc aatgatgaga tgtttaacca 2654221 attgtttcat gaacatcagc acctttctga ttttataaaa agccgaccgg caaatgccag 2654281 tcagctttct cacattaatc ttccagacgt ttttcaagct ctgctttttt ctcttcaaag 2654341 ccaggtttgc cgagtaacgc aaacatattg actttatacg cttctacacc aggctggtca 2654401 aacggattga cgccaaggag gtaaccgctc atcgcgcagg ctttttcgaa gaaatataca 2654461 aggtatccaa aagtatatgc attcagctca ggaatgttaa cgattaagtt cggaacattt 2654521 ccgtctgtat gggcaagcat tgtaccttgg aatgcttttt tgttaacgaa atcaacagtt 2654581 ttaccggcta aatagttcaa gccgtcaaga tcgttatccg cttcctcaat tgtcagttca 2654641 tgtttaggct tctctacgtt caggaccgtt tcgaataaat ctctgcggcc ttcttgtaca 2654701 tactggccta aagaatgaag gtctgttgaa tagttcgctg aagaaggata aatgcccttc 2654761 tcatctttcc cttcgctttc tccgaacagc tgcttccacc attccgcaaa gtattgaagc 2654821 gccggttcgt agttgatgag catttcaatt gttttgccct tattataaag gacattgcga 2654881 acaaccgcat attggtatgc tgggttatct tccagttcag atgttgcaaa atctttgctc 2654941 gcatccaggg cgcctttcat catgtcgtca atgttgacgc cgctgacagc aatcggcaag 2655001 agacctacag ctgttaaaac tgaataacgg ccgccgacat cgtcaggaat tacgaatgat 2655061 tcaaagcctt cttcgttaga aagcgttttt aatgcgccgc gctctttatc agttgttgca 2655121 taaatccgcg ctttcgcttc ttctttaccg tatttctctt caagaagctt gcggaaaata 2655181 cggaaagcga ttgcaggttc agttgtcgta cctgatttag aaatcacatt aatagagaag 2655241 tcaacatctt caagaagatc catgacgtct ctcatataag atgaactgat gttgttcccg 2655301 ataaaaatga cttgcggatt gccgcgtttt gcttttggca aagtgttata aaacgcgtga 2655361 ttcagcgctt caatcgctgc ccgcgctcca agataagaac cgccgatgcc gacaacaagc 2655421 aagacatcag agtcagattt gattttttcc gcgctttttt tgatgcgcgc gaattcttct 2655481 ttatcataat gttcagggag gtccacccag cctagaaaat cgctgcccgc gcctgttttc 2655541 tcatggatat tatggtgtgc tgtttttaca aagtcccgca ggtatgtaag ttcatgttcg 2655601 ttgaagaaag tcaacgcttt tgagtagtca aagcgtacat gcgtcattgc ttgtccctcc 2655661 ataacggtat aatgttttca tctttcactt tatatgaact tatctgtgaa atcaagtcaa 2655721 gaagaaaggg cggaatgact ggattccgcc ctttgggttt atagagacgc gcgaaggatg 2655781 gcaagcacgt catctttgtt cagtttttgg aagttgccga agccgccgtg ttccatttcc 2655841 ttggctgcga tatcagcaat cagctcaagc ttttcttctc caatattgta atcagcaaga 2655901 cgagaaggtg caccgaggct tgtccagaac gcagacagtt tatcgattcc ttcaagcgca 2655961 atttctttat ctgttttgcc ttcagtatca atgtcaaaca tgttgagcat aaggttttta 2656021 aaacggccta catttgtatc aagcgtgtat ctcatccaat ttgggaacag tattgccaaa 2656081 ccgcccgcgt gcggaatatc atatacagct gaaacagcgt gttccattgt atgagaagcc 2656141 cagtcaccga agtatcccat ttggagcgtg ccgtttaaag caatagtacc agcatacaaa 2656201 atcgtttcac gaagttcgta gttttccaga tcttcaagaa gcttaggagc tgtttcgatg 2656261 accgtctgca aaacagcaaa gcacattcta tcctgaagcg gcgtgttttc aacattatgg 2656321 aagtattgtt cgaatacgtg gctcatcatg tcaaccatgc cgtatactgt ttgattttct 2656381 ggaacggtga acgtattttc agggtctaaa atagagaaac gcggatgagt gacattgctg 2656441 ccccatacaa atttctcgtt tgtttcccag tttgtaatca cggaatcagg gttcatttca 2656501 gaccctgttg cagcaagagt taaaacagtg ccaaacggca gcgcatcctc cgctgttact 2656561 tttttgctga aaatatccca agcgtcaccg tcatatttga cgccagctgc gattgccttt 2656621 gtacagtcaa tcacactgcc tccgccgaca gcaagcagaa aatcaatgtc atgctctctg 2656681 caaagtccta tgcctttttc cactgtcgca agacgcgggt ttggctctac acctgacagc 2656741 tcatgaacaa cagcgccctc ttcttttaaa atgcctgtga cttgatcata aaggccgttg 2656801 cgtttaatgc tgccgccccc gtaaacaagc agtacattct tgccgtatcg tttgaattct 2656861 tttcttaatt gttcaagctg accttttcca aaaatcagct ttgtcggatt ataataagtg 2656921 aaattttcca tagtaaaacc tccaaatgat gctggtaaaa aacagatttt ccattgtaac 2656981 ataagttgac aaaaaagaaa aagggaagca gccaaacggc tatttcccct ttttttatag 2657041 tgatgctttc aaaattgaca gcacatcttc tttgttgagt gatttaaatt ggccgaatgt 2657101 accgttagcc attgccttgt cagcgattgt gtcaagctgc tcatcattaa tatcataatc 2657161 agcaagacgg ttcggagcgc caagacttgt ccagaatgcg gacagcttat cgataccttc 2657221 aagggcaatt tcttcatccg ttttacctgc ttcttcaaca tcaaacacgc gaactgcaag 2657281 ctgtttcatg cgggcagggt tttcagacaa tgtgtgtctc atccaattcg ggaacagaat 2657341 cgccagtccg ccggcatgcg gaatatcata aacggctgat actgcatgtt caatattatg 2657401 agtagcccaa tcccctcttg cccccataga aagcatgccg tttaatgcga ttgttcctgt 2657461 gtacaggatc gtctcacgca attcgtaatt ttcgagatca ttgatcagct taggcgctgt 2657521 ttcaatgact gtacgcaaaa gtgattcaca catgcggtcc tgatacggcg tgtttgatac 2657581 atgatggaag tattgttcga atacgtggct catcatgtca accatcccgt agatcgtgtg 2657641 gtttttaggt acggtgaatg tattcaccgg atcaagaatc gagaatttag ggaatacgag 2657701 cgggctgccc cagccgtatt tttcttttgt ttcccagttt gtaataacag atcctgagtt 2657761 catttctgaa ccagttgcag cgagagtcaa taccgttccg aatggcaaag catcttttgg 2657821 ctgatgcttt ttcgtaacga tatcccacgc atcaccatca tacttcgctc ctgcggcaat 2657881 cgcttttgta cagtcgatta cgcttccgcc tccgacagcc agcaagaaat caatgttttg 2657941 ttctttacag atggcaacac ctttattaac agtcgacaca cgaggattcg gttccacacc 2658001 tgctaattca tgcacggtcg ctccggcttt attcagctgt tcaatcactt gatcatacag 2658061 gccgctgcgt ttaatgctgc cgcctccgta cacaagcaat acgttttttc cgtaaggttt 2658121 gagttcctcc ggaagtcttt ccacttcgcc gcgcccgaaa attaatttgg tcggattcca 2658181 gtatgtaaag ttttgcatga catctcctcc ttagattttt tattatgcag aatgtcctca 2658241 ccacatgtaa agcaatcagc tctcaccgat cagcatacca gatggtttta ttttgcaagg 2658301 tgctgggaaa gaagctgata taagcgaggg caggccagct tccctcatat ggagaatgca 2658361 tgtatagatt ctccaatatg tcacaatcta taactgtttt aataattcat ggaggaggtt 2658421 gcaaaacatg agtaccattc aaagaatttg tcttgtatta accatcattg gcgccattaa 2658481 ctggggactg atcggatttt tccaatttga cttagtagcg gctatcttcg gcggccaagg 2658541 gtcagctctt tcccgaatca tttacggact tgtcggaatc gccggcttaa tcaacctcgg 2658601 tctgctattt aagccaaacg aggaaagatc acgtgaagaa gcagcaaatc ctgaaatgcg 2658661 ataggatatc aatcacgctg aaataggatt ttgcatgaaa tcaaaagcac cgaacattcc 2658721 tgtccggtgc ttttttcatg cttatttttt gataaggtct ttgcggttgg acatttcgat 2658781 ccactcttca agcttatctt ttaatgtgtt gaaaccttgt ggtgtagaag cttcttcgct 2658841 tacttgagca gctttaggtt ttcttggttt gctttctttt ttctcaggcg cagcttgtgt 2658901 cgcacgaatt gaaaggctga ttttgccttt ttcttcatca acagcaagta cttttacttg 2658961 tacttcgtcg ccaactgaaa ggtgctcgtt gatatctttt acgaaaccgt gagtcacttc 2659021 agaaatgtgt actaaacctt gagtttcttc atctaatgca acaaacgcac catacgcttg 2659081 taatcctgta actttaccag tgtaaacact gcccacttca aattttgctg ccattcataa 2659141 caactcctaa gttaaattaa atatctgttt atacgcaatt taaaattata tcacacatgt 2659201 cttatttccg caaagaaaac ttttttataa aaaatcaggt ttatgcacag caaaaagggg 2659261 gtaaactgaa aataccaaag gctttctagt attcccccct tttattggat gcgaacaaaa 2659321 ggttcgtatc tttttttatg ttgttttgtg caggaagcgt ttcattctga ctaacgcttc 2659381 ttgaagctgt tcaatcgagg ttgcgtatga acaacggata tatccctcac cgctcggacc 2659441 aaacacactt ccaggaacaa ctgccacttt ttcctgcgtc agtagctcct cggcaaactg 2659501 ttctgaactc attcccatgc ttttgataga tggaaaagca tagaaagcgc cgcccggatg 2659561 atgacagctg agaccgattt cattgagcga ttctacaaac agattccgtc ttcttcgata 2659621 gctttttttc attttttcta cgtcttccat gccgttcttc aggccttcaa gggcggcaaa 2659681 ctgcgccatt gcgggcgcgc acatcatcgc atactgatga attttaagca tggcatcccg 2659741 aagcaaggat ggtgccgcgg caaaaccgag cctccagccc gtcattgcaa atgcttttga 2659801 aaagcctgag atgactaccg tccgttcctt cattcccggt aatgccgcta tacttgtaaa 2659861 ttcctcatca tatgtcagct ccgcgtagat ctcgtcggct aagacgatga catcatgttt 2659921 tttggcaaac tcagcaatct cattcagctc ttccttcgaa taaaccgaac ctgtcggatt 2659981 cgatggtgag cagatgagaa tggcctttgt tttttcagtg actgccgctt caaaatcagc 2660041 agccgttgct ttaaatcctt tgtctgccgt tgtatgaacg tgaaccggga taccgcctgc 2660101 caaagaaaca agcgcatcgt acgcaacaaa acacggctca ggaatgatga cttcctcacc 2660161 tggattcaca atggcgcgga tcgcaatatc caaagcctga cttgccccca ctgtcacaat 2660221 cagctcatta tctggcgagt agctaaggtc aaacctgttg ctcaaataac ggctgatttc 2660281 ctcccgcaat gagtataaac ccgcattggc cgtgtatgac gtatatcctt gttcaagaga 2660341 gagaatgctt gcttcgcgga cattccatgc ggtaacaaaa tcaggctcgc cgacgcctaa 2660401 agaaatgacg ccttccatcg ttgccgccaa atcaaagaat ttgcggatgc cggatggttt 2660461 tatttgttgt acatagtctg ataaatacga agtcatttac ggtgacacca cgattctttt 2660521 gtcgtcgtct cctgtttcaa acactttgcc gtcatgcttg tattttttca ggataaaatg 2660581 ggttgtcgta gatacaactg aatcaagcgt tgagagttta tccgaaacaa aacgcgctac 2660641 gtcagacatc gaattgccgc gaatcacgac agacaaatcg tatacgcctg acatcaggta 2660701 aactgattca acctcttgga atcggtaaat ccgttccgcc acttcatcaa aaccgacgcc 2660761 ccgcttcggc gttactttga cgtcaatcat ggccgtaacg ccctcatgtc cgtcgacttt 2660821 tcgccagtca atcatagcgg aataatcgat aataaccttt tctttctcca gtttgtcaat 2660881 aattgttttc acttcattta cagggatgcc cgccatcttt gcgattgttt ctaaatcggc 2660941 gcggctgttt tcgtctaaaa tttctaatat ttctgtttct ttttctgtca atttcatttg 2661001 attcacacct ttgcaatgtc aagaaatctc atgacattat atcacgtttt ttgacgaatg 2661061 ctaagaaaaa acgaggagaa acttccgcta gaattgacaa tttcagggca taatacaacc 2661121 atcaaaaaaa gggagtgaca cagaatggag gcggtttcac caataaggcg gtttacggtc 2661181 gatggagtca atgtatacta cgaacattat caaaatcccg gcaggcaaac gctggtctgc 2661241 gtacacggtt ttttatcatc tgcattcagc ttcagaaaag taattcctct ccttcgggac 2661301 aagtacgaca tcatcgcgct tgatttgcct cctttcggcc aatctgaaaa atcaagaacg 2661361 tttatctata cctatcaaaa ccttgctaag cttgtcattg ggattttgga gcacttgcaa 2661421 gtgaaacagg ctgtgcttgt cgggcattct atgggcgggc agatatcgct gtctgctgct 2661481 ctccaaaaac ctgagctttt ttcaaaggtt gtgctgcttt gcagttcagg gtatttaaaa 2661541 cgttcacacc cgacgattat tttcgggacc catatcccgt attttcatct ttacatcaaa 2661601 cgctggctct cgaaagaagg cgtgatgaaa aatttattaa atgtggtgca tgacaaatcg 2661661 ctgattgatg aggagatgat tgacggctat ggcagaccgt ttcaggacga gcagattttc 2661721 aaagccatga caaggtttat ccgccacaga gaaggagatt tagaacccga gcaattgaag 2661781 aaaatgaaca agcctgctct attgatttgg ggcgaggagg atcgaattgt cccaatggag 2661841 atcggtaaac ggctgcacgc agatttgcct aattccgtgc tgtactcact tggccagacc 2661901 ggacatctgg tgcctgaaga acggcctgaa cttatttctg aacacattgc tgattttatc 2661961 aaataacaaa aaaaccggtg ctgaaccggt ttttttaagg cgtgcaggag ctgctgtttt 2662021 taatgaataa aagctggcca gccacttccc ggcagctggc gatcggcagc gtttgttcaa 2662081 aagaagtttc aaatatttgc tgaatgcttt tcgccagcaa gtcgggatcg ttttcatcat 2662141 agactgcctg cacgacatca acagcctccg tttcgtaaaa ctcttctcca tatttaaacg 2662201 ggtcccattt ggcaatgatc ttaatcattt ccctgaccgc atgactttct tccatattca 2662261 tcaccgctta taataaaatt tgcagttcta tcttatcata gtgaagctta gaagaataaa 2662321 catacatgag ggggtaacag aatgaacttt gataaacgag aagaacgcct tggcacccaa 2662381 tcggtcaaat gggataaaac aggcgaatta tttggcgtga cagacgccct cccgatgtgg 2662441 gtggcagata tggattttcg cgccccggaa gcgataactg aagcgttaaa agagcgtctt 2662501 gaccacggta tttttggtta tacaactcca gatcaaaaaa cgaaggatgc tgtgtgcgga 2662561 tggatgcaaa acaggcacgg ctggaaggta aatccggaaa gcatcacatt cagccccggc 2662621 gttgtaacag ctttgagcat ggcggtacaa gcttttacgg agccgggcga tcaagtagtt 2662681 gttcagcctc cagtttatac gcctttttac catatggtgg agaaaaacgg ccggcacatt 2662741 ttacataatc cgctgctaga aaaagacggc gcatatgcaa tcgattttga agatttggag 2662801 acaaagctta gtgacccaag cgttacattg tttattttat gcaatcctca taacccttct 2662861 gggcgttcat ggagccggga agatttactg aagctaggcg aattgtgcct tgagcatggc 2662921 gtcacagttg tatcggatga aatccattcc gatttaatgc tgtacggaca taaacacacg 2662981 ccgttcgctt cgctctctga cgatttcgct gatatttccg tgacatgtgc tgctccaagc 2663041 aaaacattta atatcgccgg attgcaggct tcagcgatca ttattccgga tcgcctgaag 2663101 cgcgccaagt tttccgcaag ccttcagcga aatggtttag gcggactgaa cgcgtttgcc 2663161 gtcactgcaa tcgaagccgc gtattcaaaa ggcggaccgt ggcttgatga attgatcact 2663221 tacattgaga aaaacatgaa cgaagcggaa gcctttttga gcaccgagct gccaaaggtc 2663281 aaaatgatga agccggatgc atcatacttg atttggctcg acttcagcgc ttacggcttg 2663341 tccgatgcag agcttcagca aagaatgcta aaaaaaggaa aagttatttt agagcccggg 2663401 acgaaatacg ggcctggcgg agaaggattt atgcgcctga acgccggatg ctctcttgca 2663461 accctgcagg acggcctgcg ccgcatcaaa gccgcattat cgtaaatata gctgtaaacg 2663521 cctttacgtc ttcatttgta aaggcgttct taataaagga attttatatt ttacttctaa 2663581 tatttagtgt tataatagat tcatatttta tacgaaagga tttcacacga atggaaattc 2663641 taaaagacta tcttctgcac atctgcttta ttttgtttcc tattcttctt taccaagtgt 2663701 tttggcttgg aaaacctgcg attcttgtgc caaaaataaa cagcggtttg gtcacgctct 2663761 tcgcctgcgg cgcctccgtt ttatgcatta ttttcccgat tcatgaaatg gactacatac 2663821 aatacggcct tcagatgatt cccgttatca tttgtttatt ttacattagt accgcttccg 2663881 gacttacagt cgccgcatct gtcctatgtt ttgaactgct tttttacgaa ccttccgcaa 2663941 tgtttgtttt cactttgctg ccttttctta tcattatccc aatcttattt cagaaaaaat 2664001 ggccattcat gtccaaagcg aaaaaactgc tgctgtcttt attgatcagc tgcgtggaga 2664061 ttttcctatt tttcgcctca agctggattc tttccgcctt gaatatttta aattttcaaa 2664121 aatcaggaat tttcgtttac gaggcggcag tctcagggct tttccgctcc agtgttcttc 2664181 tattaagcat ctatattatc gaaagcatcg ccgaaaatat cgccctgcgt tcacagctta 2664241 tccattctga aaaaatgacg attgtgagtg aactggcagc gagcgtcgcc catgaggtca 2664301 ggaatccgct gacagttgtc cgcgggtttg tccagctgct ttttaatgac gaaaccctac 2664361 aaaacaagtc gagtgcggat tacaaaaagc ttgtactgtc agagcttgac cgggcgcaag 2664421 gcattatcac aaactatctc gatatggcca aacagcaatt atacgaaaaa gaggtttttg 2664481 acctatctgc ccttatcaaa gagacaagct cccttatggt gtcgtacgcc aattacaagt 2664541 cagtaaccgt cgaggctgaa acagaaccgg accttttgat atacggagac gcaacaaagc 2664601 tgaagcaggc tgtcatcaac ctgatgaaaa acagtattga agcggttcct cacgggaagg 2664661 ggatgatcca catatcagcc aaaagaaacg gccatacgat catgattaac atcacagaca 2664721 atggggtcgg gatgacagac catcaaatgc aaaaactcgg cgaaccttat tattccttaa 2664781 aaacgaacgg aacgggactc ggcctcaccg taaccttttc cattattgaa catcatcacg 2664841 ggaccatttc atttaacagc agcttccaaa aaggcactac ggtgaccatt aagcttcccg 2664901 ctgatcttcc tcactagcaa atcgattgga actttaatag aataaatgcg aggtgatgac 2664961 agatgagcac gtttgagaca ggctctatcg ttaaaggatt ttacaaaaca ggtgtataca 2665021 taggagaaat cacggcttgc aggccgcagc attatttagt gaaagtgaaa gcggttctta 2665081 cccatcccgc tcagggagac cttcatcatc caaaacaggc ggatgtgcca ttttttcatg 2665141 agagaaaagc gctcgcatat ggtgaacaga ccaatatccc ccaccatatg gtgaagcctt 2665201 atgacggtga agtgccggat tataccgaat ctctgcggga ggcgacagca cagatgagag 2665261 ccaaattgaa tgaggatggt tcggagtggg caaagcgctc ccttcataat ctggacattt 2665321 tagaaaaaga atattttaac cggccataac ccagtctgac aaaagattgg gttttttacg 2665381 tcgcgcgctt caacagttcg gttaaatcga ttctctcgcc gattgtgggc ggttttggct 2665441 tttcgagata ctgcttatcc tgctcaacaa gcttaaaaag tttatatgct gtgagagcat 2665501 catcaagcgc tttatgatgg gtgccggttc cggaatctcc atactcttcg gcagctttcc 2665561 ataaacccgt caatgtccgg tctccaaaaa agtttttgta ttcaagcgat aaatctctca 2665621 tttctccctt aaacgggaaa gggatatggt taaacataca gttttgcttc agcactttca 2665681 tatccatgtt tccccacgta ataattgtgc tgtttttctc aggatccagc tcgtttagtt 2665741 tacggatgaa atcctcgaat ctcattcctt cgtctacctg tttttgggtt atttttaaaa 2665801 atgatttgca gcgtttcgta agcttcggga actttttcgg tctaacatag ctagaaaacg 2665861 tctcaaccac ttcatcatca atcgacttta caattccggc ttcaatgatt tccgggaaga 2665921 agttttgagg actgtacttt ccatcaggca ttgtaaattc gaaatcaata atgagtaagc 2665981 tgtttgtcgt caccttttac acctgccttt cctccgatca gaaaatgcta tctttatagt 2666041 atatcaattc cccttctcga catttcttca ttttctaaaa ataatgaatt ttcccagccg 2666101 cttcgtttct tttaaattgt gaatcgtttc tttataatta gtaaggaacc cgaaataata 2666161 agaaggtgat gttatttcta tccgtaagaa aaactttgtc attgtgtggc tggcgaactt 2666221 ttttgtctcc gctagcacaa cgatgatcgt tccttttctc tccttataca ttgagacgct 2666281 cagctctttt tcaaacggct ttgtgcaaag gtggagcggc tatgtgttcg gcattacatt 2666341 tctcatggcg tttttggtat ccccgttttg gggacggttc ggagacaaac gcggatacaa 2666401 gaaaatcctt atggcaaccg gaacaggcat tgccctcagc attttcttca tgggctttgt 2666461 tacatcggtg taccaattgt tttttctgcg tatggcaatg ggtcttgtaa ccggattcat 2666521 cccgacatct cttgcgatga tttcggcaca gactccgaag agctcagctg gcaaaacact 2666581 cggcacgctg caaatggggc aagtgtccgg aagcttgttc ggcccgcttt tgggaggcat 2666641 gcttgctgat cgtttcggct ttacgtatac cttttttatc acatcctttg tgattttctc 2666701 gtctgttctt ctcgtgttat ttggtgtcaa agaaaagcat cttgcagaga aaacagccaa 2666761 acgtacgtct tactcgagaa aagaagtgct ctcctatatt tttcaccatc cggcgctgtg 2666821 ggtcatgatg ctgttaacca tgctgattca aacaggcaat ttcagtatcc agcccctgct 2666881 cgctttatat gtaaatgagc tgcacggacc tgtcaatctt gcctttttct ccggcatggc 2666941 attttcagca acggggctcg gaagtttgct gctggctaga aaatggggtg atctgggcga 2667001 ccgctacggc caccgccgca ttttaatcgg acttttgctc gccgcctctt tcttttttat 2667061 tccgcaggcg ctcgcgtcct cactcagcgt gctccttgtt ttcagatttt tattcggaat 2667121 ggcgatgggc ggtttgctgc catgcattac ggcagcgatc cgcgttcagg ctcccggcag 2667181 cattcaaggt gaagttctcg gctacaatgt cagctttcgc tttttaggaa acgtgctcgg 2667241 gcctctgctc ggcggaatca tatcgagcca ttttaccatt tcggccacct tttacgtcac 2667301 ggcgtttctc tttttcgccg gcgcctgcat gctttggatc atgcagaaac ttcggaaaga 2667361 ttcttatgcc aaagcaagct gattccgaga aaaaactaag gaatcttcta aatttaacct 2667421 tctcgtaatc tcaaaagaat ggtacgatat ggctagaatt taggagaaaa gagagtgacc 2667481 atgttacgaa aaataatcgg atggattttg ctcctttgca taatcccatt gtttgcattt 2667541 acagttatcg cttccggaaa agaagtaaaa caaatgaagt ccctggatca ggtgcttgat 2667601 aaaaatattg atctgaaaga tatcagcctt gttcagaaca gctacatgta tgacagggac 2667661 ggctcccttg tctcggaaat cgtcagcgac cacgaaaacc gtgtgctcgt tccatttaac 2667721 aagattcccg aggaagtcaa acagattttc ttaacatctg aggaccgcca tttttacgag 2667781 cataaaggct ttgactttat gggaatggtg cgggctactg cttctaacgt aaaagacaag 2667841 aaaattgacc agggtgccag caccatcaca cagcagcttt caagaaactt gtatttgagc 2667901 cacgaacgct ccttcagccg caagctgaca gagctcgcgt attcctatca gctggagaaa 2667961 aaatatacga aaaatgaaat tcttgaagct tacttaaata ccatttattt caacaacggt 2668021 gtttacggcg tcggttcagc agctcaattc tatttcagca aaccgctgaa atctctcaca 2668081 gtgggagaaa tggcttttat ctgtgctata cctaataacc ctacattata tgatcctctc 2668141 aagcattttg actacacgaa aagccgtcaa gaacgtttac ttaaagggct aaaagatgcc 2668201 ggggtcatta cggacaaaga gctgaaaaaa gccgtaaaac aaaaaatcaa actggatgtt 2668261 gaaaaaagag aagacaaata tcctgactac gtttcctacg tcaatgatga attcactcag 2668321 ctggtgtctg aatcagaagg ctttgataaa cgccttcaaa aagcatcagg aaaacaaaaa 2668381 gaaaagatcg agaacgagct gtccgcaaga gtcagcacgc tgatgaaaga cggagtgaaa 2668441 atttatactg cacttgatcc gtacatgcaa aatcaagttg tggcacaaat gaattccaag 2668501 ctcccgtatg cggacgtaca gggcggagcg gctgtgatta atcaccagac gcatcaaatc 2668561 attgctctat ccggcgggaa aaactatcaa aaatatgact ttaaccgcgc ctaccaggcg 2668621 tacaggcagc cgggttcatc cattaagccg cttcttgatt acggccctta tattgaacag 2668681 accggcgcga caacaagcag caccattgat gccagcaagt tttgcagcaa agactactgt 2668741 ccgcaaaact acaataaccg cacttacggc acagtgacgc ttgatacggc gtttaaaaat 2668801 tcatataata ccccggctat tagaatgctc gaccgcgtcg gcatccaaaa ggcattcagt 2668861 tatattgagc cgtatcattt tgccaaactt gtcgacagtg actatcttct tccggcggcg 2668921 cttggcggat ttacaaacgg catgacgcct cttgagatga caaaggctta tacgacattc 2668981 ggaaacagcg gaagctatac gccgagccat gcgattacaa aggtgacaga ccttaaagga 2669041 aaaacacttt ataaatggaa tgataaagcg actcaaatat tcagcgtccg cacgaacatg 2669101 cagctgaaaa aactgatgtc ttccgttgtg aaaagcggaa cagggaaaaa agcatatttc 2669161 aatgcgcctt acatcggcgg taaaaccgga acatcaaatg attatcacga tatgtggttt 2669221 gtcggcctga ctgatacgta tacaatgggt gtctgggtcg gaaaggatac accgaccagc 2669281 gttgaatatc ttcacagcat cagccctcag ctttccatct ggaaaggaac gctgcaagcg 2669341 gcttattaaa ggatcggagg ggatatggag tgacttcaga acaaattcca aatcgcgttt 2669401 tgctgtttga cggtgtctgc aatttatgca atggcgccgt gcagtttatc attaaacgtg 2669461 atccggacgg attgatttct ttcacatcgc tgcagtcgga aacaggacag agcctgctga 2669521 aaaaaagcgg gcttccgact gatcggtttg acagctttgt ctttattgaa gacggccaag 2669581 tgtacacaaa gtcaactgca gccattaagg ttttcaggca tctgcgaggc ccatggcggc 2669641 tcttcgtcct ttttttcgca gtgccgaagc ctgtcagaga tatggtctat tctttcattg 2669701 ccaaaaaccg ctataagtgg tttggcaaaa aaaatgaatg tatgctcccc tccccttcca 2669761 ttaaaaaaag atttttaccg taaataaaaa atggctagga agctagccat cacagattgt 2669821 tgacaaaatc ctaaaacggc ttcgttttag gattttgtca tctattcagc gtgattgaaa 2669881 acttttgaag ttgtgaaacg gcggaaacct gagaatctag ccgccgtttc attgcgtaca 2669941 gagcacgaag cgcaaatctg accaccaaac gctgaaatgg ctagcttaca caggtaagct 2670001 agccattatg ctattataaa gcttgataaa tatgaacaga ataccgataa caaaggtaaa 2670061 ccaaaacagc agttccaata gaatgaatcc aactaatgac atgagagaaa gcgtcgaata 2670121 aatccggtat acggtaaaca caaagtaagc gagcgtgacg accgcaaacc agatcacaat 2670181 ccaaatgaca ttttgcaaga gcacaaagga taaaatcccg ccgcccaaat aaatcatgga 2670241 acccattctg agttttttca ggttgttccc ttccggatca ttagcaaaaa acagcaatga 2670301 cagctcggtc acggtatttg caattaattt cagagcggac agaaccataa aatataaaag 2670361 tgcaaaggca gcaaataacg caagcctgat tcctttctct gaaaaataat cgagcattcc 2670421 atcatacatt ccaaatgaag acagcatctt caacgcataa agtgaagttg agatggataa 2670481 ggacgaacta aaaagcagga tcgcaatcag cggaaaatat cctgtcaaat aagtattttt 2670541 catataaaaa agtccctttc tataatctac ctcatttatt atggaggact taaaacacat 2670601 tgacaagata aattattcca ttttttctcc tttttacgaa ttacgggccc aaatcttcac 2670661 aaagcagcat tttgagagta aagtagtacg caggaatcat aaaacgtaag gaagttttat 2670721 atgaaaaaaa cattaaaact gcaaaccaga ctcaccatat ttgtttgtat cgttgtatta 2670781 atcgcattgc tcattacgtt ttttacagtc ggtgcccaaa ccaccaaacg aattagagat 2670841 caggaaaagg ccactgcgct gcagactgct gaaatggtag ctgaagcgcc gatgacagcc 2670901 gctgctttag aaagcggaaa aaaacaaaag gaactgcaga gctacacaaa gcgggttcag 2670961 aaaattaccg gcacggaatt tgttgtcgtc atggatatga acggtatccg caaaactcat 2671021 cctgacccga gcaaaatcgg aaaaaaattc agaggcggtg atgagtccga ggtattaaaa 2671081 gggcatgtcc atatcagcac agcctctggc acgctcggga aatcgcagag agcgttcgtc 2671141 cctgtctacg cggagaatgg aaaacaggtc ggtgcagtcg cggtcggcat caccgtaaat 2671201 gaaattgatg aagtgatcag ccatagctta cggccgcttt actttattat ttgcgtcagc 2671261 atcttcgtcg gtgtgatcgg agccgttatc gtcgcccgta cagtgaaaaa tatcatgtac 2671321 ggacttgaac cttatgaaat tgcgactctg cttgaagaac ggagcgcgat gctggaatcg 2671381 acgaaggaag gaatactcgc tgtcgatgaa catggcaaaa ttaaacttgc caacgcggaa 2671441 gcaaaacgcc tattcgtcaa aatgggcatc aacacaaatc ccattgatca ggatgtagat 2671501 gacatcttgc cgaaaagccg cttgaaaaag gtcattgaga caaaaaaacc tcttcaagac 2671561 agagacgtcc gcattaacgg gctggagctt gtgtttaatg aagttcctat ccagctgaaa 2671621 ggacaaactg tcggagcgat tgcaacattc cgcgacaaga ccgaggtaaa acatttagct 2671681 gaacagcttt ccggtgttaa aatgtatgca aacgcactga gagcgcagtc tcatgaattt 2671741 atgaacaaac tgcatgtgat attaggtctc gtccagctga aagagtatga tgatcttgga 2671801 gattatatta aagatatagc catacagcaa aaatcagaaa caagtgaaat tataaatgat 2671861 gtcaaaagct ccgtactggc cggttttctg cttggaaagc aaagctttat acgtgagcag 2671921 ggcgcaaatc ttgatattga atgcaacggt gtcatcccga acgcggcaga cccttctgtc 2671981 atccatgaac ttattacaat catcggaaat ctcatcaaca atggcttaga tgccgttgcc 2672041 gatatgccga aaaaacaaat caccatgtcc atgcgcttcc ataacagcat acttgatatt 2672101 gaaattaccg atactggagc aggcatgtct gaagaagacc aagccaaagt atttgaacaa 2672161 ggctattcaa caaagggcaa aaaccgggga ttcggccttt atttcacaca gcaaagcatc 2672221 gaaaatttaa aaggccaaat gatcctcaca agcgaaaaga atgaaggaac gacattcagt 2672281 attcgcatcc cgtacgaacc gaaggaggaa aatcatgatt aatgtactaa tagttgaaga 2672341 tgaccccatg gtgggtgaat taaataaacg atacttaagc caaatagatg gctttcagct 2672401 gaaaggcatc gcttcttcct ttcaaagcgc tctgcatatt ttaggggagc accatattga 2672461 cctcattttg cttgatattt atatgccggg aaaaaacggg ctggaactgc tgacggaatt 2672521 gagagcccaa aatgaagcgg ttgacgtgat tgtcatctca gcggccagcg agcttgacgt 2672581 gatcaagaaa acacttcggt acggagctgt tgattattta atcaaaccgt ttgaatttga 2672641 acgattccaa acggctctgt ctgattacag acgaaaacaa aaggtgtatt caacccatcg 2672701 caacatgagc caaaaagaac tggacgccga gctttttcaa aagaaagaag caacagaaaa 2672761 agtgcagctt cctaaaggcc tgacaaaaag cacgctgaag ctgatctggt ccagtatcca 2672821 gtcatttgaa aatgaatctt ttacgacaga agacttggca aagcacacag aaatctctca 2672881 agtatccata cgaaaatact taaagtttct tgaagatata caggttctga atgtagaaat 2672941 ggcgtacgga acgatcggaa gacctgtgtt tcagtacaac gtcaacaaca gtaacattaa 2673001 cggaataaag caatatctat aagaaaacgc actgcttgct ttgagcagtg cgtttttctg 2673061 tcatatctct tgccaagatg cttgattcta ttgttgataa gttatacaag aataacaaag 2673121 ggctttcaca tttttaagca aataattcta aaaatagata atttttaaaa aattatgcga 2673181 aattctattt atttcttatt agttaaatga taaattatga ttggttagtt gatcccgaaa 2673241 aactaagtca taagtcttac ttcagaaaac gatgtcacgg ttttccgccc ggaacgcctt 2673301 ccgcatcctt ctcttccccg cctttcgaag gaaatactca caccacgctt attcagggaa 2673361 gaatagaact gtctcagcgc attccatttg ttattatcag aaaattttat cgattctaag 2673421 aaattgttca ggacagccca tcacatgact ggccggatca gctttgaacc aaatttttct 2673481 ggggggttat atcttgaata aacgaaaaat cggattggcg atgtcacttg tgatcgcagc 2673541 aggcaccata ttaggagcat gcggaaacag cgaaaaaagc agcggctcag gcgaaggcaa 2673601 aaacaaattc agtgtggcga tggttactga cgtaggcgga gtggatgaca aatccttcaa 2673661 ccaatcagcc tgggaaggca tccaagcctt tgggaaagag aatgggctga aaaaaggcaa 2673721 aaacggttac gactatcttc aatccaaatc tgatgcagac tatacaacga acttaaataa 2673781 attggcgcgt gagaattttg acttaattta cggcgtcggc tacttaatgg aggattcaat 2673841 cagcgaaatt gctgaccagc gtaaaaatac aaactttgcg attatagatg ctgttgtcga 2673901 taaagacaac gtcgcaagta ttacgtttaa agagcaggaa ggctcatttc tcgtcggagt 2673961 ggccgcagcc ctatcaagca aatcaggaaa aatcggcttt gtaggcggca tggaatcaga 2674021 gttgatcaaa aaattcgagg tcggcttccg tgccggcgtg caagcagtta accctaaagc 2674081 cgttgtagaa gtgaaatacg cagggggttt cgataaagcc gatgtcggta aagcaaccgc 2674141 cgaaagcatg tataaatcag gcgtagatgt tatttatcac tctgcgggcg ccactggcac 2674201 aggcgtcttt actgaagcga aaaacctgaa aaaagaagat ccaaaacgcg atgtctgggt 2674261 catcggtgtc gataaagacc aatacgcaga aggccaggta gaaggaacag atgataacgt 2674321 caccctcact tccatggtga aaaaagtaga tacagtcgtt gaagatgtaa cgaaaaaagc 2674381 gagtgacgga aagttcccgg gcggcgaaac acttacctac gggcttgatc aagacggagt 2674441 cggcatttct ccatctaaac aaaatctatc ggatgatgtg atcaaagcgg tcgataaatg 2674501 gaagaaaaaa atcatcgacg gattggaaat cccggcaact gagaaagagc tgaaaacctt 2674561 caaagctgaa taagaatcgc agggataagg aggtcgagcc cttatccctt gtttttcttt 2674621 tattttgaaa taaaggagcg gtcaatcaat ggaatatgtc attgaaatgc tcaatatccg 2674681 caaggcgttt ccaggtatcg tcgccaatga caatatcaat cttcaagtca aaaaaggcga 2674741 aatacacgcg ttgctcggtg aaaacggagc ggggaaatca acattgatga atgtcctttt 2674801 cgggctgtat cagccggagc ggggtgaaat tcgggtgcgc ggcgagaagg tgcacatcaa 2674861 cagcccgaac aaagcgaatg accttggaat tggaatggtg caccagcact ttatgcttgt 2674921 tgacaccttt acagttgctg aaaatattat tctcgggaag gagccaaaga agtttggcag 2674981 aattgaccgg aagcgtgctg gccaagaggt gcaggacatt tccgatcgat acggcctgca 2675041 gatccatcct gaagcaaaag cagctgacat atcagtcggt atgcagcagc gcgcagaaat 2675101 attaaaaacc ctctaccgcg gtgccgacat tctgattttt gatgaaccga cggctgtttt 2675161 gacgcctcat gaaattaagg aactgatgca aattatgaag aacctggtca aagaagggaa 2675221 gtccatcatc ttaatcaccc ataagctgaa agagattatg gagatttgtg accgcgttac 2675281 ggttatccgt aaaggaaaag gcatcaaaac ccttgatgtc cgtgatacaa accaagacga 2675341 actcgccagt ctaatggtcg gccgtgaggt atcgttcaaa actgaaaaga gagctgctca 2675401 gccgggagcg gaagtgcttg cgattgacgg cataactgta aaggataccc gcggaataga 2675461 gacagtcaga gatttgtctc tttctgtcaa agcgggagaa atagtcggca tagcaggcgt 2675521 cgacggaaac gggcaatctg agctgatcga agcggtgaca ggactccgca aaacagattc 2675581 aggaacaatc accttaaacg gaaaacagat ccaaaacctg acgccaagaa aaatcactga 2675641 atccgggatc gggcatattc ctcaggatcg ccataaacac ggtctcgtcc ttgattttcc 2675701 aatcggagag aatatcctgc tgcaaagcta ttacaaaaag ccgtattcag cattgggcgt 2675761 tttacataaa ggcgaaatgt acaaaaaagc acgcagcctg atcactgagt acgatgtcag 2675821 aacgccggat gaatatacac acgctcgggc attgtcaggc ggaaaccagc aaaaagcgat 2675881 tatcgggcgg gaaatagacc gaaatcctga tttattaatt gccgcccagc cgactcgcgg 2675941 ccttgatgtc ggagcgattg aatttgtcca taaaaagctc attgagcagc gtgatgccgg 2676001 gaaagccgtt cttctcctct cgtttgagct tgaagaaatt atgaatctca gtgacagaat 2676061 cgccgttatt tttgaaggac gcattatcgc cagcgttaat ccgcaggaaa ccactgaaca 2676121 ggagcttggt ctcttgatgg caggaagcac gcaaaaggaa gcggggaaag caaatggtta 2676181 aacgactctc tcatttactc gtgccgctca tcgcaatcat acttggtctt gcggccggcg 2676241 cgttgattat gcttgtgagc ggctacagtg tggctagcgg atattcggct ttgtggaatg 2676301 ggatattcgg agaaatctat tatgtcggag aaacaatccg gcaaattacg ccttatattt 2676361 tatccggatt ggctgtcgcc tttgcattcc gaaccggact ctttaatatc ggcgtcgagg 2676421 gacagctgct cgtcggctgg acagcagcgg tttgggtcgg tacggcgttt gacggaccgg 2676481 catatattca cttgccgctc gcattgatta cagcggcagc tgcaggagga ttatgggggt 2676541 ttattcccgg cattttgaaa gcgcgatttt acgttcatga agtcattgtc accattatga 2676601 tgaattatat cgcgctgcac atgaccaatt acatcatttc aaacgtcttg acagatcatc 2676661 aggacaagac ggggaaaatt cacgaatccg cctccctccg ctctcctttt cttgaacaga 2676721 tcaccgatta ctcacggctg catttgggaa tcatcgttgc ccttctcgca gcagttatca 2676781 tgtggtttat catcaacaaa tctacaaaag gatttgagct ccgggcggtc gggtttaacc 2676841 agcacgcttc ccagtatgcc ggcatgagcg tgcggaagaa tatcatgacc tccatgctta 2676901 tctccggcgc ttttgcaggt cttgccggag ccatggaggg cctagggaca ttcgaatacg 2676961 cagcagtgaa aggcgcattt accggcgtag gctttgacgg tatcgctgtc gctcttctcg 2677021 ggggaaacac agccgtaggc gttgtactgg cagcatgcct gcttggcggg ctgaaaatcg 2677081 gcgcattaaa tatgccgatt gaatcaggcg ttccatcaga ggtcgttgat attgtgattg 2677141 ccattattat tctatttgtg gcttcaagct atgcgattcg tttcgtcatg ggcaaattga 2677201 agaaaaaggg ggcgaactaa gtggacattg tgcagatttt atctatcatt gtccctgcca 2677261 cactcgtcta tgcggccccg cttattttaa ctgctctcgg cggcgtgttt tccgagagat 2677321 caggtgtggt gaatatcggc ctagaaggcc tcatgattat cggggcgttc accagcgtgt 2677381 tatttaattt attttttggt caggaattag gtgccgccgc accttggctt tcgctccttg 2677441 ccgccatggc agcaggcgcc ctgttttcac tgattcacgc ggcagcggcg atttcgtttc 2677501 gcgccgacca gacagtcagc ggtgtcgcca ttaacatgct ggcgcttggg gcaactttat 2677561 ttatcgtcaa actgatctac ggcaaagcgc agacagacaa aattccagag cctttttata 2677621 agacgaaaat ccccggtttg ggcgatattc ccgtcttggg aaagatcttc ttttcggatg 2677681 tctattatac gtctattctt gcaatagcac ttgcctttat ttcctggttt atcttgttca 2677741 aaacgccgtt cggccttcgt atccgttctg tcggcgagca tccgatggcg gccgatacga 2677801 tgggaatcaa cgtatataaa atgcgctaca tcggcgtgat gatcagcgga ttgttcggcg 2677861 gtctcggcgg cggcgtatat gcctccacaa ttgcgcttga tttcacgcac tctaccatct 2677921 ccgggcaagg ttttatcgcc ctggcagcgc ttgtattcgg aaaatggcat ccgatcggag 2677981 cactgggggc cgccctgttt ttcggattcg cccaaagctt aagcatcatt ggatcgctgc 2678041 tccctctttt taaagacata ccaaatgtgt atatgctgat ggctccttat atcttaacga 2678101 ttctcgcttt aaccggcttt atcgggcggg cagatgcgcc aaaagccaat ggcgtgcctt 2678161 atattaaagg aaaaagataa acattctccc ctgggaagac gattctcagg gatttttttc 2678221 taatccaaaa gaccccctta atttaattgt ttattagttt tttaacttaa aaaaatatga 2678281 agtgttaacg ctttcttgta gactgtaaca aacaatacat gggggtgtat gacatgggag 2678341 caattccaaa aacggggaca atttcacctg agcaaaaaga ctcacaggag aaaaacctgt 2678401 ttcaaaaaat ttggtcttgg gaaatcggtg tgattccttt gccattatac acagtattag 2678461 ctgttattat tattcttgca gcatattaca atgagctgcc ggcaaatatg cttggcgggt 2678521 ttgccatcat tatgattctt ggtgtgtttc tcggagacat aggccaacgc ataccgatat 2678581 tgaaggatat tggcggccct gctattttat ctttgtttgt tccttcattt ttagtctttt 2678641 acaatgtact gaattcaaca tctttagacg ctgtaaccaa cttgatgaaa acgtctaact 2678701 tcctttattt ctatatcgct tgccttgttg tgggaagtat cctcggtatg aacagaattg 2678761 ttttaataca ggggtttatc agaatgttcg ttccactggt tgcaggaacg atcgcggccg 2678821 ttgcagccgg catccttgtc ggatttattt ttggctatag tgcctatgat tcctttttct 2678881 ttgttgttgt cccgattatt gccgggggaa taggtgaagg gattttgccg ctttcaatcg 2678941 cctattcaca aatactgggc tcatccgccg atgtatttgt gtctcagctg gtgccagccg 2679001 caattatagg aaacgttttt gctatcatat gtgcagcctt aatgaaaaag cttggcgaca 2679061 agcgtccaga tctaaatggg aacggacgtc tcgtaaaatc taaaaaagca aatgagattt 2679121 tcaatcaaaa agaagccgaa gcaaaaattg attttaaact aatgggagca ggagttctgc 2679181 tcgcgtgtac attctttatt tttggcgggt tattggagaa attcatcttc atcccgggcg 2679241 cgatcttaat gattatttca gctgcggctg tcaagtatgc aaatattctt ccgaaaaaaa 2679301 tggaagaagg cgcttaccag ctttataagt ttatttcttc aagctttaca tggccgctga 2679361 tggtcggtct cggcatcctc tttattccgt tggatgacgt agcgtctgtg atttctatac 2679421 cgtttgtcat catctgtatt tcagttgtta tcgcgatgat tggttctgga tatttcgtag 2679481 gcaagctgat gaacatgtat ccggttgaat ccgcaatcgt tacctgctgc cacagcggtc 2679541 tcggcggaac gggtgatgtt gccattttat cggcatcagg aagaatgggc cttatgccgt 2679601 ttgcccaaat ttcaacccgt ctcggcggtg caggcacagt tatttgcgcg acagtgctgc 2679661 ttcgtttttt cacttcataa acagaaagag ttccgtttta tgcggaactc tttttttatt 2679721 tattcacaat ccgaatatac tctcggggac caaacggcag atcctttgat tccgtctcac 2679781 tcattctggc tgacaggtgg tgctccagta aatacagctc ccactcatca caagccgcca 2679841 caccgctgcg cccgtcatat tgattcaaca tgaatgcccc tgcaaatact gagcagaata 2679901 aacctgagca catcacgact tttgttttca catgaccagc tcctttcctt cagcttgatc 2679961 aggattgatt ttaaatatac aaataacctc ttttttgtta gacttatttt gaggtcaaaa 2680021 gaactcataa aaatccatta cagcagttcg aagcgtggca gcttgcagaa aagtgcgata 2680081 taatttggac taggtcgttt gaccgtatat tttatacata gcgcattttt caattgagaa 2680141 cgagaaaagg aggtcttatc tttgcagctc ttacatcttg ctattttatc gcctttttta 2680201 tttgctttta tcattccctt cttggcaaaa tacgcaaaaa gagtgcatac gggctggttt 2680261 gtgttgatcc tgcccgtctt gctgtttata tactttctcc caatgatcag gatgacgcaa 2680321 tctggagaaa cacttcgatc ggtattagag tggattccgt cactcggcat taactttacc 2680381 gtttatatag acggcctcgg gttattattc gctttactga tcacaggcat tggctctttg 2680441 gtcactcttt acagcatttt ttatttatcg aaagaaaaag aacagcttgg gcccttttat 2680501 gtctacttat tgatgttcat gggcgccatg ctcggcgtcg ttctagtaga caatgtcatg 2680561 gttctctaca tgttctggga gcttacaagc ctttcatcct ttttgctgat cggctattgg 2680621 tataagcggg aaaagtcgcg ctatggcgca gccaaatcac ttttgattac ggtcagcggc 2680681 gggctgtgca tgctcggcgg atttattctc ctttatttga taacggattc cttcagtatt 2680741 cgagagatgg ttcaccaggt tcaattaatt gccggccacg aattgtttat cccggctatg 2680801 attctcattt tattaggggc ttttacgaaa tcggcgcaat ttccttttta catctggctc 2680861 cctgacgcga tggaagctcc gacgcctgtc agcgcttatc tccattcagc tactatggta 2680921 aaagccggca tttatgtgat tgcgagattc agtcctattt tcgccttttc agctcagtgg 2680981 ttttggatcg tgtccctcgt cggcctcttt acgatggttt ggggttcatt ccatgccgtg 2681041 aaacaaactg atttaaaatc gattttggcg ttttcaaccg tcagccagct cggcatgatc 2681101 atctccatgc tcggagtcag tgctgcggcc cttcattacg gacatacaga atattataca 2681161 gttgccgcta tggctgccat tttccatttg atcaaccacg caacctttaa aggaagcttg 2681221 tttatggcag tcgggattat cgatcacgaa acaggcacac gggatatccg gaagctaggc 2681281 ggcctgatgg cgattatgcc gattactttt accatttcct taatcgggac attttcaatg 2681341 gccggcctac cgccgtttaa cggatttttg agtaaagaaa tgtttttcac aagcatgctt 2681401 cgcgtgacac attttgacct gttcaacgtg cagacatggg gcgttctgtt ccctcttttc 2681461 gcctggatcg gaagtgtatt tacgtttatc tacagcatga aattgctgtt taaaacattc 2681521 agaggaaatt accagcctga acagcttgaa aaacaggctc acgaagcgcc tgtcggtatg 2681581 ctcgttccac cggtcattct tgtcgctttg gctgtcagtc tcttcttttt cccgaatata 2681641 ttgtcgtaca gcctgataga gcctgcgatg aactcaatct atccgacact gcttgacggc 2681701 catgagaaat tccacgttca catttcacag tggcatgggg ttacaacgga attgctcatg 2681761 actgcgggta ttgttgtgat cggaacaatt ggttatttgt cgctgaataa gtggaaagga 2681821 atctataaac tgtttccttc gaaactcaca ctcaaccggt tatacgataa gcttttgact 2681881 atgatggaga aaggctctta ccgggtcaca aaacaatata tgaccgggtt tttaagagat 2681941 tatttgctgt atatcttcgc tggtttcatc attctgatag gcggagcttt tgccattaaa 2682001 ggcggatttt catttaaaac ggaaggcatg gctaaaatcg gtgtatacga aatcattttg 2682061 acgcttgtca tgatcagcgc cacagtggcg actgtttttg ctaggtcaag actgacggcg 2682121 atcattgcac tcggtgttgt cggttatacg cttgcattgt tttttgtcat tttcagagcg 2682181 ccggacttgg cattgactca gctcgtcatt gaaacgattt ctgtggcact gtttctgctt 2682241 tgcttctacc atttgccgaa actgaggctg aaaacaaaaa cgagaacgtt ccggatgacg 2682301 aattttatca tttctttagg cgtcggtgtt atcgttacac tgctcggcat cgcatcctca 2682361 agccagcgga caaaagacag cattgcgtcc ttctttgtca aacacagcca cgatctcggc 2682421 ggaggggata atgtcgtcaa tgtcattctc gttgatttca ggggatttga tacaatgttt 2682481 gaaattacgg tattaacgat agccgctctc ggcatttaca gcatgattaa aacaaaagta 2682541 aaagaggagg ggaaaagcgg tgaatgaaca aaaaacaaat gacttgattc ttcaaaccgc 2682601 gacaaagctt gtatccttta tcattttgct tttctctttc tatttatttt tatcagggca 2682661 taacgcgccc ggaggaggct ttgtcggcgg actgatcacg tcctcttcca tcgttctctt 2682721 gctcttggca tatgatttaa aaaccgtgcg ttcccttttg cctgtcaatt tcatttatgt 2682781 cgcgggagcc ggccttctgc tcgctgtatt aacaggcgtt ggctcctttg tcttcggggc 2682841 tcctttttta acccacacat tcggatactt tcagctgccg atccttggga aaacggagct 2682901 cgccacagcg acgatatttg atttaggcgt ttatcttgtt gtcgtaggca taacgatgac 2682961 cattattcaa acgattggag aggaagaata atggaaatct taatggctgt attagccggt 2683021 attattttta tggctgctac gtatttgctg ctgtctaaaa gcctgcttcg cgtcattatc 2683081 ggaacagcac tgttaagcca tggcgttcat ttaatgcttt tgactatggg aggattaaag 2683141 aaaggcgccg ctccgatttt gagcgagcat gccaaatcat ttgtcgatcc gcttccgcaa 2683201 gccctgattt tgaccgcaat tgtcatttct tttggcgtta cgtcattcat cctcgtcatg 2683261 gcctttcgcg cttatcagga attgaaatcg gacgatatgg atcaaatgag gggaaatgat 2683321 caacatgaat aattttgtta ttttgccaat cctgatcccg cttttgtcgg ctattcttct 2683381 gattttcatg acgaagaatc ttatgctcat gagaatcttc agcacggcgg catcggccat 2683441 cgggattgtg attagcggca tacttgtaca gactgtcttc acaaaaggca tccagacact 2683501 cagcctaggc ggatggaaag cgccgtacgg cattgtgctt gccgcagacc aattcgccag 2683561 ccttctcgtt ctcacaacag cgatcatcgg tttattggtt gggctttatt ccttccgttc 2683621 tgtcggtgaa aaacgggagc gctcctttta ctactccggc gttcagttct tgcttgccgg 2683681 cgtcagcgga gcgtttttaa caggcgattt atttaatatg tacgtatttt ttgagcttct 2683741 gcttattgct tcctatatgc tgattgtatt aggcggcaca aaaattcagc tgcgggaatc 2683801 ccttaaatat attgtgttta atattgtatc gtctgccctg tttgtcatag gggtcggctt 2683861 tttatacgct gtaaccggta cgttaaacat ggcggatctt agcgtgaaaa tcagcgaatc 2683921 aggacaaacc gggctgatca ctgtgattgg tgtcctgctg cttttggtat ttggcatgaa 2683981 gggcggaatc ttccccctct acttttggct tccaggctct tattacgcgc caccggcggc 2684041 aatctccgcg ttgttcggcg ctttgctgac aaaagtcggg ttatatgcga ttacgagggt 2684101 tttcacattg atttttattc acgatacagc ctttacccat cagttgatga tttggctggc 2684161 ggcgctgact gtgatttttg gtgtgatcgg ttcactcgct tattcgaatg tcatgaaaat 2684221 tgtgatctat aacattatta ccgctgtcgg cgtgattttg ttcggtgtgg cagtacacac 2684281 ccccgcatcc attcagggcg cgatctacta tctgattcac gatatgctga ttaagggcgc 2684341 tttgttcatg ctggcaggta cgctgatcgc attgactgga accgcgagcc tgcataaaat 2684401 gggcgggctg atcaaacgct atcctgttct tggatggatg tttttcattt ccgctatttc 2684461 tcttgcaggc attccgccac tgagcggatt tgtcggcaaa tttaaaattg cagagggcgg 2684521 cttcgcagaa ggtgaattta cgatatccat gctgattctg ctttcgagtc tgcttgtact 2684581 gtactctgtg ctgaggatct ttatacatgc gttttggggc gaagaaaaag aaacgccaaa 2684641 accaaatcat cgaacagcta aaggacttct ttatccggca gctatttttc tcttgctgtc 2684701 ccttctcttc ggattgggta cagaatgggt gtcgccttac gttgatcaag cggccgagac 2684761 gctgctgaat ccggaaaaat atatcgaagc tgttctgaag gagtagatcg catggcattt 2684821 caaattttat taaatgtgtt tctcgctttt tgctggatgt tcttaagcaa cagtccaagc 2684881 gccgcaggat tcattacagg ctatattctg ggaatgctct ctctcttttt cttccggcgc 2684941 tttttcactc gccagtttta tctatggaaa ttgatttcta ttatcaagct ctgtttcatt 2685001 tttataaagg aactgtacct tgccaatgtc agtgtgatga aatcagtctt atctccaaaa 2685061 ctgaatatca gaccgggtat ttttgctttt aaaactgaac tgacgaagga ctgggaaatc 2685121 accatgcttt ctctgctcat tacattaacg ccgggaacct tggtgatgga tatttcagat 2685181 gacagaacaa tactttatat tcatgcaatg gatatcgagg atgcggaaaa agcgattttt 2685241 gacattcggg agtcatttga aaaagccata caggaggtga gccggtgatg tttacgctga 2685301 tcctgcaaat cgcgctcggc attatggcag tgtctacctt tttgtatgtc attcgtgtca 2685361 ttaaaggtcc gactgtgcct gaccgggtcg tggctctgga tgcaatcggc atcaatctga 2685421 tcgcaatcac ggcgcttgtc tccattttgc tgaaaacaag tgcgtttttg gatattattt 2685481 tgttgctggg gattttatcg tttatcggaa cgatcgcatt ttccaagttc ctggagaaag 2685541 gagagattat cgaaaatgat cgaaaccgct aaggtcgttg tggctgtatt cattttgctg 2685601 ggtgctctta tatgcctcat tgcttcattt ggcgtacttc gccttcccga tgtgtttaca 2685661 cgcgctcatg ctgcttctaa aggctcaaca ttaggtgtca atatgattct gctcggtgtc 2685721 ttcttctatt tgtggtttgt gacgggggag ctctccgcta aaatcctgct tgggattctc 2685781 tttatcttta ttacgtcgcc tatcggcggg cacttgatct gccgtgctgc gtataactcc 2685841 ggcgtcaagc ttgatgagag aagtgtgcaa gatgactata acggaatcag aaactttgtg 2685901 attaaacgaa aagaggattc ttatttataa aaataagcag ccggacaggc agagttccgg 2685961 ctgttttttt atttcttgat gacagccagc gtgcatctgg atatacagat cagcctctct 2686021 tgctcgtcat atatgtgaat atgatagaca atcgtcgttc tgcctatatg aacgggctcg 2686081 gctatcgcct ttaccgttcc ttcctttaca gattttaaat ggttggcgtt aatctccaaa 2686141 ccaacacaag cttgcgttgt atgatcaatc aggttctgtg cacctgcgct cgccgcggtt 2686201 tccgccaggg ccactgaagc gcctccatgc aaatatccga acggctgtac cgtccgatga 2686261 tccaccggca tgaccgcaac gcatcgttcc gctgtgtttt caacaatctc aataccaagc 2686321 gcttcaagca atgtgtgctt catatccatc tctacacccc ccaacattta aagtacaccg 2686381 tctgatttcg caatcaaaac cgcttccgtc cgtgaaccga cattcagctt attgaaaatc 2686441 gatgtcaagc tgtattcaat ggaccgcttg cttaaatgaa gggcatctgc gatttcttgg 2686501 tttgtaaatc ccttttcaac ttcttgaaga atcaggcatt ctctaggtgt gagcacatct 2686561 tgttcttttt gagaggaagg agccggcttt gttttttgct gagtcatcag ctgtttaaag 2686621 taagcaaaat cgactaaaat ttctccgttg agtacgtggt atatgtattg ggtgatcttt 2686681 tctttagatt ccgttttgct gatggcaccg tgcagacccg cacgaatcgc ttcctcgaaa 2686741 taatcctcga cctcataacc ggtatacacg ataattttac aatgaggatt ctcttgtaaa 2686801 atctgtttag aaagctccat cccattgacc tcgccgccta gattcagatc cattaaaatg 2686861 agatcatatg acgagaaatc atgctgcttg ataaactgtt cgctcggttc aggactgaga 2686921 caatcaacag acaaattcga atccgtttcc aaaattgtct tggtgccttc catgacagcc 2686981 ggatggtcat caatcactag tatctttttc atgttttcct cccttttact cactcttttc 2687041 cattttataa aaaagacttg gcctgtgcca agtcgtttcc gttataaatc cattacaatt 2687101 cgatttcaat atcagcctta aagccctttc cttcacttgt ttcaatccga aggcgcccat 2687161 ctaaagccct gactctctcc ttaatgccag aaagccccat gctcatggaa tgctcagtat 2687221 ttttttcttg atcaaaccca acgccatcgt cctcataatg aagaacgatt ttgttttgaa 2687281 tactgatgag cataatcagc acatccgtcg cctgagagtg cttgaccgca ttagacagaa 2687341 actcttgaat gatccggtac aaattcagct gcgaatccag atcaagggaa gccgtaaatc 2687401 tcccggtatt taaacggata tgaaacggaa cccgctcctg ctgctgcgcc accagcttcg 2687461 acagcgcctt caccaatcca agatcataca gaagctgcgg ccgcagctca tgacacgtct 2687521 ccctcgtcat cgaaatcaca tcagacatct gctcattcat ctgtacaagc ttgtcctgca 2687581 cctcttcacg gcacggatta tcatccttct tgaaatcacc caaaaacagc tcacactggc 2687641 gttttaagga aatcaaatcc tgaagaaccg aatcgtggag atcgcgggcg agtcctgaac 2687701 gctgtttttc ttcgattgca aacattagct ttttcagcca gatggggttg gttccctctt 2687761 gttttaagtc cttcaaatgt tccatgagct cctcaatatg caggacattt tccatggaca 2687821 cacttgtata aaaagacagt gttttcagcc acgatatttc atcacgtgtt agccggggag 2687881 tgttaatatt agataaacaa agcagaacat aagaactacc gcctcgttca ccaactttca 2687941 taagaaagcc ttgattgact tctataattt tcccaatttc tgaagttacg ttttcaaatt 2688001 cctcttgata aaaattccag tccggtccaa cttcatgctt atctaaaaat atcactttgt 2688061 gatcaggagt aacctcaaag gtataagctt tgcttacaag caaaacatcc agtatagtat 2688121 ttttcagttc tttaaaaact tgttgaagag aagttacacc cctcattagc tgagtatatt 2688181 taaaaatact gtcctgatag ttgaattttt cggagaaacg ttttaaccga aatttaaaat 2688241 ccatgacctc tttaaaataa aagacagcga acatgacaac gaaaaaaaat acagtttgac 2688301 gcacagggtt catctggatg tccattacat caaacagaac taatgcacca actattagaa 2688361 gagttggtat catggcaagt agagcatagt atctcattct tcctaagata aactctatat 2688421 caaacatctt attggctaca aattggtata ctaacccgaa cggaattagt actagtaatg 2688481 acgccgaagc taatgccggg aaaatataat tacctgtaaa tattattgga agaacaaaaa 2688541 atatcaaaaa aggcgcaaat gaaagagtgt ttgttaaaat tagtaattta agaataaacg 2688601 aatgctcagc atatttatat ttattaagat gtaagtatat cgctgaaaaa gaaaatagag 2688661 tcaaagttgc aaaagaaacc aaattaagag ttgctaaaaa atcaatatct acttgtaaat 2688721 agtcttgaaa aaactcaata ccaagattaa atattggtat gatataaaga aaagaaattc 2688781 tattcaaaaa agttttacct atttctccaa ggtatctttg tataaattga agataaagaa 2688841 taggagaaga tataaaagta aacaagttaa tataccgatt gattatatgt cctctaaatg 2688901 gtccgcctgc acttatatat gctatcgaaa tgtctaataa caatagaata agaatatagg 2688961 cagcaaatga tctccttttt ttatttactt taagtatata aaaaatacat attatgctta 2689021 aaaaataaaa aaacaaagga agtacgaaca gaaaaaaact ataaggtcta tttagagtaa 2689081 ctaaatcaaa atctttgaga tgaatctttt ttccacttct caaaatatcc agactgttaa 2689141 tatgactcaa atatccccat ttcaaatgtt tgtctgaagg tttttcttta ttaattttta 2689201 atatgatgtc tccctgtctc agaccaacaa attgtccata tgaagattcc gatatttctt 2689261 ctatcataaa ttgactttta tcatttttat gaatcttagt cccaataata attccattca 2689321 tactgatata agttgtatag cttatataaa ggatactcaa aacaattaca gctattgtga 2689381 atttttttat taagttcttc aatattaatc cacctattaa tcaccccatt gacgggttat 2689441 tggatcagcc agataataat cattataagc tttaattatt gtttcagttt cttgcacatc 2689501 aaaacctata aggcaggctt ctttattttt caattttttt aaagcctcag gataatttaa 2689561 aaagtagtta attaggtctt gcatcttgta tccccctttg tataacttaa taagcattcc 2689621 tttattagct ctttttttct ttatctaaat ttaattgttc tatagcagaa atacatttct 2689681 gtttatatat ttccaataat accgaaatgt attgagtaac tcccgcttta attaattttt 2689741 cttggaattt ctctttatca agtaacgatt tataatataa gtctttatgt gaaattaagt 2689801 ataataaatc ttccgaagca tcattaaaaa ggcgcttaag atataagtaa atcagtgtat 2689861 gtttgttttt ttcaatatca ctgcgatttc cggataaaag aacataataa tctccagaaa 2689921 tttgagctat aatcccttta tagtaggaat atctttcaac tgtttcatta tattctcctg 2689981 tagccaataa aacacctgct acatttgcta gtgcaatcag acttccacat tttaatctaa 2690041 ttacttctaa actttcatct tctgttttag atttattagt gatatcgtca tgttgacctt 2690101 gcatggcctc gtttacgtat tttaaaacat atttaaaaat tagaggattg ttatttaatg 2690161 aataaatact cgttaatcct actgtataca aggaaagtgc tgcatttaac gactccgagc 2690221 gattaatttt catccataat gcatggtgat tatcttcatc ttcaagatca tccataatat 2690281 ctgatgaaag aataagaatt tctattcccg cgccaagcct tgttgcaaca tctaaattct 2690341 cccctccaaa aacaacataa tgtaagattg tggattcagc aaaggagaat gtttctttag 2690401 aatcaataaa tgagtaaaga agttgtgaca aatcctcgtt aaatatgttt tgctccacaa 2690461 tctccttcat tttctccttg atccggacag aatctaaaca tatctgctca ataacgactt 2690521 cccccctccc attccatttt actaaatggg acatttaaag gacagcaggt ttttcgtttt 2690581 ttaacaatca tataatactt tatccattta ttgtatcggt agaacgaaaa aaaagacttg 2690641 tttccaagtc tttttcacga aattttcatt gcataattgt atttatcgag ttgatcaatg 2690701 cttttgttaa tgtttcgtaa tgaatctgtc gtttctttaa tatcaagttc gagtcggaat 2690761 aacaattgtt ttacttcttc aagtttcttt tccatcgttt ccacactcct ttttttgaaa 2690821 gatcaatgaa ttgtgtatgg tgaacgagtc ctaggtattt gatctgttac taatagtgtg 2690881 tctgctttcg gctcattttt caccgaaaag tatgcaaaaa agtcctgcgt gacaccgcaa 2690941 atctcaatag gtccttatac tcaaaggaat cacaacaaga acgggactat ctttctatgc 2691001 gaaagagcgt ttatatgtgc tgaaattgag aaagattctt aatctccttg attttaacgg 2691061 gtttcgcatt ttcactaagc aagactatag tccttcatac cgtattttca aaattgaata 2691121 tgcgattctt ggcgtttcct gaccgacaaa caccgaaaaa gaccgcaacg ctaaagttgt 2691181 ggccttttcg ctttgtcata ttcggcaatt agggatctat acatatagaa acatcctttt 2691241 ttgcgaggtg ctcccatgag atatcgttat ccctggtttt acgtgtatcc gtatgaggta 2691301 cgccgtccgc ccgctcctgc caacaatatt gataccttta tccgttcagc gaagcaggcc 2691361 gcagggatat ttgcggatgc ccagctcgtt ctcagccgca ttgcgggctc gcgggagctt 2691421 tcgcgccgca ttctgaccgc agccgaacag tctgataaac aaactataag gcgcctgatc 2691481 aaacaaatgg gcgtccggca tgaagtggat acggtcttta atcccgacgg catctatatc 2691541 agccttatcg gaacgcaaag ccgaatgatt cttgctttgc ggtggtcaga ggaccgcaat 2691601 cattttgcgt ccataagatt atgacaccat tccagagcct ctaaataaca ttcatacgct 2691661 tcttctttgt ccagttgatt gcctaattct gagcaagtgt cccagttgtt gctttcaatt 2691721 aatttcacaa gctcaagcat ttggtagtag tcgttttgat ggcctaataa tgcttgcccg 2691781 acttcatctt ttaaaggcaa ttcttgaaca atttcctcta tttctctatg caggagggtg 2691841 tctatgagag aaaacattcc gatcagcata taagaagcag gctgcggccg ggatgtcttt 2691901 ctcgccagca gttcgcaaag ctttgctctt atcagagaaa tcttaatgat ttcgtgcttg 2691961 ctggaatgcc ctttcctgct taaatcctta aaggaaagaa tatatatcca ccgtttgatt 2692021 tcattaaatc ccagcagcat aatggcctgt tgaatgcttt caattttctg gctcaaacgg 2692081 ctgtgggatg agtttaaaaa ttttaaaatt tgataggaca gtgataaatc ccgctctatg 2692141 tactctgtca cacgctttat gttaggctgc tctttactca gttcgttaag cagttcatag 2692201 taagaataga aatgagtcga taggtcatgc ccgctgatga tgcgcggctc gctgaaaaag 2692261 tagccttgga ataattgaaa gccgtcttgg accgcctgtt tatattcttt tcgggtctct 2692321 actttttccg ctaaaaaaat caggccgcgg cagccgtagg tttgcaaaat tgttctgcgt 2692381 tccattcgtg ttgttttgag aaaatcaatt ttcaatatat caatatagct catgagtttt 2692441 tccagtaagt cctcatcttg cggatttatt gcataaaaat catcaagcgc cagcatatac 2692501 cccatttttt tcaattcttt gcatctagaa atgagggccg gcgtgatcgg tatatcttca 2692561 aggatttcaa tgacaagctg tttcggattg aaggaggtgg gaagattcga aaacatcagg 2692621 ctttccgtaa aattaacaaa acagcgtttc ccttccgtca gcttctcaat tccgatgttt 2692681 aaaaagctgt tgatcaccaa atctgttgtt gcctgatcgc cgtctttagc gctatacacg 2692741 ttctcttcgc tttctctata cagcagttca taagcaacaa cctgttcttt tctattaaaa 2692801 ataggctgtc ttgcaacaaa caccctcatt gatttatccc ccttacaata cgcgcggctt 2692861 tcacccctaa gtatatcaaa taatttgacg aaaattgtct aaacatgaaa aataatatat 2692921 acataaagaa aactggccct tcgcgaatga aaggccagtt tttctttatt cttcctcaag 2692981 ctcttcttca attctgcttt tcacttcgtg gatccgctgc attttattgc tccagcagtc 2693041 ctcgcttaaa tcaaccgggt attcctccgg cttgctgatt ctcttatatt cctcccaaag 2693101 caggctgagg ttatcctgca catactgctg tatgtctgaa atctcagggt tttggtagca 2693161 aagaataccc ttctcaaaaa tcagttcatg aagatccttc gcataaaaat tcgtgacaaa 2693221 tttgctgatg aatgtatgaa ccgggtggaa cattctgagc cgcttctgat cattcacctg 2693281 ctcatcataa agcgcaatat agtcgccttc agaatgatgg ttggactgat taataatgcg 2693341 gtagactttc tttctgcccg gtgtcgtcac tttttcagga ttggacgaaa ttttgatcgt 2693401 gtcgaccatt ttcccgtctt cttcaatggc aacgagttta taaactgcgc cgagagccgg 2693461 ctggtcatag gcagtgatca gcttcgtacc gacaccccag acatcaatgc gcgctccctg 2693521 agcctttaaa ttcataatgg tgtgctcatc caaatcgctt gaagcaatca ccttcgcatc 2693581 tgtaaatcct gcttcatcaa gcattttccg ggcttttttt gacaggtacg ccaaatcgcc 2693641 gctgtccaga cggatgccaa tgaaattaat gcggtcgccg aattccttgg caaccctaat 2693701 cgcgttcggc atgcctgaac gaagcgtgtc atacgtgtca actaagaaga cgcaatcctt 2693761 atgtgtttcc gcgtattttt tgaaagctgt atattcatcg cggtaagcct gcacaagcgc 2693821 atgcgcatgt gtgccggaaa ccgggatatt aaagcgcttt ccggctctta cattgcttgt 2693881 cgcgctaaag ccgccgatta aggctgctct cgctccccac atggccgcat ccatttcgtg 2693941 cgcccgtctt gttccgaatt caagcgcaac ttcatcaccg atgacgcctt taatccgggc 2694001 agcctttgtt gcgattaatg tttgatagtt cacaatgttg agcaaagctg tttcaatcag 2694061 ctgcgcttct accaggggtg cctccaccct cataatcggc tcattgttaa aaacgagttc 2694121 tccttctttc atggagtaaa gtgaacctgt aaaagataag ccgcgcaaat attcaataaa 2694181 atcttcatga tacccgagtt catcctgtaa ataactcaaa tcgctatccg taaacttgaa 2694241 attttccaag tattcaatgg ctttttccaa gcccgcaaat acggcatagc cattttcaaa 2694301 cggaagcctt ctgaaaaaca gctcaaaaat cgctttcttt tcatgaatgc cgtctctcca 2694361 gtacgtttcc gccatattga tctgataaag gtctgtatgt aatgacaggc tgtcatcttt 2694421 aaatccgtac tctaacactg tttttcccct tccttactct gccacttgcg ctccgatgct 2694481 gtttgcaaaa tgggaaagag cccatgcgtg cccctcctga ttaaagctgg caacagcttg 2694541 tttatgcaca acaatccgaa aacctttgtt gtatgcgtca acagctgtat gcaacacaca 2694601 aatatctgtg cagacaccgg caagatgcag ttcgccaatc tgccgctctc tgagtttgag 2694661 ctctaaatca gttcccgcaa aagcagaata tctcgttttt tccatgtagt aaacattagg 2694721 ttcatgttca tgtttctgat atagaggcaa aagctttccg tacagatctt ttccttccgt 2694781 gccttttata ttatgcggag gaaaaagacg ggtttcaggg tgatattgat ccccttcatc 2694841 atgagaatct actgctaata cgacgtaatc accgtttgtg atgaattctt tagttaaatt 2694901 gacgatcgcc tcttcaatca ttctgccggg ctccccgcag gtcaattttc cgtcactcgc 2694961 cacaaaatca ttcgtataat caatacaaat aagtgctttt ttcatagccg gcctccccgc 2695021 catcagtatg agaacattat atcttatctc cagttgtaag tgaattgcca tgaacaaaaa 2695081 gacaaacggt ccgtttgtct cttacgattt cagtactgac cgattataaa tgtcgtcctg 2695141 aatatatatc aattcacgat tcacagcgat atcagccgca atgacgatgc ctaagggcgt 2695201 atgaaactgg agatcagata caatcttgaa aggcactccg taccggctcg ccatttggat 2695261 ataagaagag taagactgat actgaagctc tccattaatc aaaagggtga cgttatggct 2695321 gtttttcagc tcgtgctctg cctctttata cggtttgctt ctaagcacct gtcctttcgt 2695381 cagtgccaaa acgactcttt ctcttaaaga gcctaaaaac aaatggcgct cgtcaggctt 2695441 tgtctccaaa ggcccataca ttccttgctg caaatagaga tccattttat cttcactcaa 2695501 aagcctgtcc tcccgtcttg tttgtcttca ttatcacctg atcaggcagg agctaaactt 2695561 tcaagcgccg tttacatttc tgttacccaa tgaatgattt ttttggccag ctcaccagca 2695621 ggggtttcct ctgtatgccg gcgcaacgac gcttccagcc gttcaggcag agttgcttta 2695681 tcttcttcat aggaaatgat cgtgctccac tccagctgcg gtaccgctac aagcgtgcgc 2695741 agttcttttc tgttttcatg cagatacacg tccgtgatca ttccggtttg cgtattgata 2695801 tttgcttttc tgattttcat aacatgacct ctctattcaa agactaccca tattatacaa 2695861 taaaaaagca acagcctctt gtgaaaaggc tgttacccgt taaacgaaac tgtttcatca 2695921 gtgatatcgg catctttgaa gagagtttta ctcgtttggt tgttaatctt cacaaaatca 2695981 ccaagctgaa atgtgcctga ccccgcccct gaatgagcga cgcttttggg cgaaatcgca 2696041 aatacgtctc caaagcttgc cgcggcatta tccgtaactg acatgatata aatcggcccc 2696101 acaattgcag gcatttcccc acctccgcat tgatttacag catcatatgc aaggagccga 2696161 taatggtgcc cgcctattca gctggctttg cgttttcctc gagtcgtgac cgctggcgca 2696221 gcttgatcaa gcggacaata ttcaggaaga acgccttcac taccgcataa accggcaccg 2696281 ctaaaatcat gccgagaatt ccgccgaagc ttcccgctcc gattaatagc aaaataatcg 2696341 taagcggatg ggtattcagc cgctttccga tcacaagagg agacagcagg tttccgtcca 2696401 gctgctgaac gatgacgacc acaataatcg caaacagcgc tttggccggc gagtccataa 2696461 aaccgacaat gacagccggc gcggcaccga gaaaaggccc gacataggga atgatattgg 2696521 taatcgccat gacaatccca agaatcaggg catacggcag tccggcaatt aaatagccga 2696581 taaaacacgc tgttccgaca aaaagacaga ttaacagctg cccctggaaa tatgccgcaa 2696641 gcgtatcgga taaatcttta aaaatcttta agccttctgt ccgataagaa gccggtagaa 2696701 tttttactgc caaatgcgga aagcggtgtc cgtctttcag catgtaaaaa aggataaatg 2696761 gaacagtaat aataacaagc gtgatgtttg tcacgacacc aaacaccgca gataaactgg 2696821 acgtgatatt ttgcggcagg ttttggagaa aacttgtcaa tgactgttca atttttgata 2696881 tcgatacata atcctggttc atcatccagg taaaccattg agaatgggac aaatcctttg 2696941 tcagcgcctg aatctgtttt atataatcag gaaggttgtt aaacagccct gtcacctgtg 2697001 cggtgatgat aggtccgact gacgctgaaa taaaggcaag caaaccgata aacagtaaat 2697061 agatcaatag aatggataat gtccgcggaa tttttttctc aagcaggcgg acgaccggat 2697121 taaatatgaa atacaaaatt cccgcaatta gcatcgggaa aaacaatgtc gagataaaaa 2697181 caataaacgg ctgaaataca aatgaaactt ttgttgctac aaaaataatc agcaaaacaa 2697241 ataaaatctg caatgtccaa aaatggactt ttgatttcaa caagctttgt tcctcctagt 2697301 ttttctttgt ctgtcagata aaagaactta taccccatca ttgtaacaaa aatgaactca 2697361 tatcagaact cttaatataa tgaaaggagt gttggtgatg aaggccgtga catacgatac 2697421 agattcagaa ctggcttata tctatgttct tcctccgaaa aagaacagga atgtacggac 2697481 tgaggagctc agagtcaatg attgtctcct gctggatatc agccaagatg gcaaaatcgc 2697541 cggattcgaa tgttttggtg aggcagcaca cctctgtgcc ccatttgccg ggaaatcccg 2697601 gctgtatgta aaagattcag acggttatca ttttcgggtc tgccagcatg cttcagtccg 2697661 ttcctgctat acggtgtacc gtgtcacttt ctgtttttca gatggtgact atcaggaatt 2697721 tgccggcttt gaccttgatg gaacaatgta tcatagtgcg tttttacagc gcttaactga 2697781 aaaataggac gtcctgttgt acgcctattt ttcatgcgca agcactgtta gacccgctca 2697841 ctgtaatctg gggtgacgga aatcatgtgc tggattctga tcaaacaaac agaatttcgg 2697901 gctccttcaa ttgtgatatg gtcaggtttt acatcgatca gtctgcctct gaccgtatct 2697961 cgtactgtct gtataacgaa ccttgagccg atgagctttt taatggtctg atagacataa 2698021 ggatcgacta aagagaccag ttgcggacta ccttggttga ccatactttt atcccctttg 2698081 tgtgttttat ctcagcttat gccgcgctta tggataatga cacaggctta cctgataaaa 2698141 caaaggggtg cggagatttt aggagaatac gtttggaggc gggtgtaaag gaagtatcga 2698201 tgaagcggag acagcgaaga aagctggcgc tgttccgtac ttatacaggc tttatcacgg 2698261 atgcctgggc ttggtcgatt aattggtcca gcttttctat tttttttcgt gcggttgaag 2698321 gatcaatttg gcggtaatga tggtggccgc ccggctcttc atccagttcg tccgcttttt 2698381 tgacaatctg ctgcagtgtg tttttatcta attcgccttc aggcaaatag gaatctgtat 2698441 gaagcaaaat ggctagtgca atctcttttg ctgctttcgg ttcctcgcca agccgaatca 2698501 gaagtttatg cgcccgttcc gcccctttaa tggcatgaat gtcatttctt ttgtatttct 2698561 cataatccca ctttccgtct gtataccatt cataatggcc aatgtcatga agcagtgccg 2698621 cttttgctgc taaatcagga ttaatgtcag ccttcacaga cagcctgtat gcatgataag 2698681 cgcaggcaat cgcatgtgcc acgccggaac gctgaagata tttttgtgca attggatggg 2698741 tgaaaacatc cattaatgta acctttctca tggaaacccc tcctttagat atttttagaa 2698801 tcctaacata atttgcagag aaactcaatt cttatgtcac atcattttga tcttcttatc 2698861 atcattgtta taccctaaaa gcaacgtttc agtcagtata tgcggctgtt caataaaatg 2698921 cgctggctgc agccttttgt ataaaaaaaa gagcagaaaa tatctgctct acaaaaactc 2698981 tttaatatca taaatgcggc cgttttccgt ccctttttct agtaaagaaa gcagcgtgcc 2699041 ggcaataaag tccggactgc gaaggcttcc tgtttcattt aatttccgga atcgttcaat 2699101 gtggtggaaa tcctttttcg atgaagaacg gatgacggcc tgcatctcag tgtccatcac 2699161 tccaggtgag aacgaaatca tgttcaccgg cagctcttca tcctcctgtt caaatccgaa 2699221 tgtcctcgta aacatgtcga gcccggcttt tgaactgcaa tacgcgctcc atcccttata 2699281 tggatttttg gcggctcctg aagtaatgtt gacaaccgtc tttttgccgc tgtatgaagc 2699341 aaaccgtttt gtaaacagct gactcaaaag cacgggcgca gtcaggttca gctgataatg 2699401 gcgctgaagc tcgtcaagag acgcttcgcc ggcacgtttg atcggcgtta ccattccggc 2699461 gttattaata agggtaatac cagaataacg atctgaatcg atggatgaga gcaatgtttc 2699521 aaattgctgt tcagcttctt cgagattgat gaggtctatt tgatgctgcg ttagtttttt 2699581 gtgagagaca tctgttttcg ttctggataa ggcatggact tcatgcccct tttctaaagc 2699641 ctgtaatgca atggcttgac ccagcccttt tgacgctccg gtgatgatat aaagttccat 2699701 tggaaacctc cttttccgtt attattgtac ggcacctctt ttacacaaca caagcacgcg 2699761 gcctacgcct tcttgttttc ctgcgctgtg acttttggga tgaggaacac gatgcctgca 2699821 attccgagca ggatcagtac gacatagatc atcggcagca gcaatgatga tgtttcttgt 2699881 tcatcttctg tttccgttga tgatgtcttt gtcattggtt tttcagcaaa agtaattcca 2699941 agctgtttcg actgggccgc aatcgtgttg gaatcctcgg catttgttga tgtaaacaaa 2700001 tcttttatca gctcggcgtc cttgtccttc ggtttatcaa aagtgatatc cttttgttcc 2700061 tcaggcagtt ctgttttttc ttcatagtag gtatcttcat gcaaataatt cgtatcgatt 2700121 tcgatgtctt ttttctcata ctggtttggc gcgacatctg tattttcttc agtttgggca 2700181 gccgctgcag agggtatgaa aagggaaaag gagagcatac aaatcatgat ccccttttcc 2700241 atgctgcgat cacgcttcat acgtttcatc gctttctgct gtgtgttcag ccatcaaccg 2700301 gataatcagc ggcagagcca cggcaatcac cgtaatgatc agcagaactg ttattcccat 2700361 tgtaaacaag tgcccagtac cgtactggat gtcgatatat actttcgaaa ccggatcttc 2700421 aaatgtaaag ttcggcatga tcaaatcaat aagcggtgcg acatagaata ggatcattgc 2700481 tgctgaagca acccagccag ggattgatcc gaatctgaat gccgtccgga tgaaggcaga 2700541 gcttgcgacc agcaatagaa tcgtaaacac cgaccactta atcgtctgat cgtccggcag 2700601 tgaataaata ttcaagccga acaagctgat cataagtccg acaaggatat tcagaattcc 2700661 gaataacgct cctttgacga gaagcggtgc gttttggtaa tacgagctga aatagccgat 2700721 taacagactg ctgatcaaca caatgacaag gatgacaacc ggaggtaccg tctgaatttt 2700781 ttcttccgga acctctccgc tgattttaag cggattcgct aagtaatcat atacatagcc 2700841 attgttttgc ccgtctacta atgtatttcc gagtatgccg tatacgtcat ttcgcacgag 2700901 tttcgtggag gcgacatttt tcccccagtt gttgtttaag gtgtcggctt tcgcttgaac 2700961 atcattaacg ctttgctgca tgttggttgt gtaatcaatg atgccggact ggcgatcaga 2701021 caatgaaccc atcatgtctg acatttgcag cacttcctgg ccgaccgtat cttggacact 2701081 cagtgccatg gtaccagaca gcccatcgtt gctgaacgtc gcagattcct gtgttgcgcc 2701141 cgttacaagc tgttctgacg cttttgcggc actttcagag attttcgtca gttcgtcgag 2701201 aacacctgct tgagagtcac ggatatagcc gctgtagtcg tccgcaaatt tggtcatgcc 2701261 gtcgatgaag ctgttaatat cctcatctgt ttgcatcgtg ttgtttttga gagcttccca 2701321 gctggctgat tcttcaggtg tgagagccag gactgattgg acgttgccat cttgctcttg 2701381 gatgacttca cctttaataa tagtcaaaga gcctagatcc agattatcat ttagcgtaga 2701441 cttatataaa tttaaagagt tgtaatactt catcaagtta gaaatattat cagtttcaat 2701501 tctacttgaa aaaattgaac ttagtttttc tttctgatct atatagcctc tactctgcaa 2701561 agtttgtatt atttcgtctt ccaaattgta tattaaccta taagcatcat tgacattatt 2701621 atcaaaatca accaactttt ttgttaagtc accaatttga tcatttaatt ttgaaactgt 2701681 tttatttaac tctttaattt cttgatttaa ctcatcaata tgtttctcta gtttgttgtt 2701741 atgttcctct tgtttttctt gaagtgcatt ttctatttcc tctaatttta tcgctgcttc 2701801 gttcagacgt ttttttgcac ctgaaatatc agtttcaccg tcagctccgt caccctgtag 2701861 cccatcactt tgatttgagc catcgttttc atctgcgagt tcaatcaaag agaaatctgt 2701921 tttagaggtt cctgtattct ccgtgtttgt atcttgttca ggaacgtttt ttgaagattc 2701981 ttgatgtttt tgtcccgttt caatgttagt ttgaacatca ttttgtgatc cattatcttg 2702041 agtaccctct tctgatgagc cagtatcttc atttgttggc tgatcatcgg atgttggaat 2702101 atcattcgac ggttcttcag tattaggaga atcatcggtt gatggttctt cagcatcggg 2702161 tgttgttggt ttttcttgtt caggttcttt taacccttca gagatatctt taatttcagt 2702221 tgcaacattt ttgagctcat cccgctgctt ctctaaatcc aattttatat cttcaatatc 2702281 ttccttatct gtgtcatctt tattatcaga tgtgtcttct ccatcttcct tttcgtcgct 2702341 ttccttaggt ttaagtaaac taaggcggtt cttcccgata ttctcttgca attgatttaa 2702401 attttgatat ttaatagctt catattgact tttatatcga gatagaaatg cattaaacat 2702461 gtcattctca atttttttca tacccatttc ttgcaatggc acttgatttt gccttaactt 2702521 ttcagcattg ttcaacgcaa ggtttgtcag tcctatttgt gtcttcgctt ggccgatccc 2702581 ggttgccaat ccgctcatgc gttcgctgaa ctgattcgcc ttttgctgtg cctggatggc 2702641 atccagacct gtccggattt gctgctgtgt tgaatcctgg gctgccaaaa gcagcttttt 2702701 ctgattctct tgatattctt tgtacctttc aactgtatca atgaattctt tcagcgtgtt 2702761 tttggcttcc tccgccgtag aagctttttc ttttgtcgtg ccttgcgctt cattcattga 2702821 tttcttcagc tcatcgatta agtctttttg ctgtttgatt tcacctgcta aatcattaga 2702881 gcttggtttg taaaagttgt acatgacatt ctggaattca gattctttat tgacgatctt 2702941 gtcaaattct cctctgatgt tgtccacttt ttgcgaaaca aaattccagt ataaggccga 2703001 catttttttg ttcattgtct tttgggcatc ctcaagctca cgctgaactt tttctttgtt 2703061 aaccgcattc aggttatctt gaatgctgaa ttcgagcgtt gccttttgag gatggtcttt 2703121 gtcatagctc aaaatgtttt ttgagaagtc tgagggaatg tagacaatcg catcgtattt 2703181 ctttgaagcg agaccggtct cggccgcgct tcggtttacg accgtccacg aataatcagg 2703241 acgttcaccc agaacggccg ctacttcctt gccgaactgg gcggatttgt cctcttcatc 2703301 agactttacc tcatcactca atacgcctgt gtcttcattc accaccgcga tttgccgggt 2703361 agaattgact gcttttttcg ttgggtcgtc tccgataaat cggaaaaaca acaccggcag 2703421 cagcaaaatg atgatgacgg cggatattaa cttgatcaag ctttttcgtt gttctgtcat 2703481 ctagcactct ccctttcagc agaacataaa ggaatttgaa ctttttgctc cttcccgttt 2703541 tccacaacat atccgaagcc cggctgaatc tcaggctcct gtctttggta cgggagagga 2703601 atgacatttt gctcagactt tttcatcagc agaatcgcgt ggcggatttg cttcatctca 2703661 gtcgtcaagg agtcatagcc ttttgagaat tcgctgtggt ttccgcccgg gataaagctg 2703721 aacccaagat gagcgtatga tttcatgaag ttagcgagac gatcttgtat tctcgtatca 2703781 atcgtctgct ggaatctcgt tatcccgtca atcatcagca cgacttgtga gaatcgcaga 2703841 ttttgtgcgt ctccttggcg gacggcttct acatacatgg cttctcttgt tttgaaaatg 2703901 tcttctgctg tttcaatcca ctgctcaata tcttctttcg tttccaaata tgaaacatct 2703961 gattccttcg cataatgaga taagccgcgg tcaatcgagt caaacaggcc gatcatttcg 2704021 gtttcatcat caatcagatg ttcaagcatg acttttagga cgtttgtttt cccgcgctga 2704081 gtttggccta aaatcaggca gtgcttatgc ttgcccaaat caaaatagac tgggctgact 2704141 gtttcttcat gaagcccgat cggtacagat aaaggcttgc gttccagctt gaagcggata 2704201 gacaattctc tcgtcgacaa gctctcaggc agcatcggaa tcggtgccgg ctgctccatt 2704261 gaagcaaatc gcccttgaag tttctgtacg tctgatttca gctcgttgaa catgccgata 2704321 tcatcatcgg cgtcaacagg caggaacatt tgcgcgaaat aaagctcttc cttttgaatg 2704381 atgacgcgtc ccggaatcgg ctcaagattg aatttcggac ggccgtaaat ggaatatcct 2704441 tctgattgat ccatgagata atggacaatc tttgttttca agttatttaa caatgactgg 2704501 cggacagcat tcacccgcgt tgctgtcagc ataaagtaga tacccaagct ttgtccgtct 2704561 ctggaaagct ggacaaattc cgattcaagc tcatgcatct catccttgac aatgtcaaag 2704621 ttgtcaatgg tgataaaaat gaatggaagc tcttcttcgc tcagcgcatt gtacattttg 2704681 atgtggctga tttctttttc ccggaacaaa cgtttacggc ggtcaatttc ttctttgatg 2704741 cgaatcatga acttttcaat tttccttgac tggtccatca ggaagtaatc cgcggtatgc 2704801 gggagcttcg ctaatggcag cagcgttccg tttccgaaat caaagatata gacatgaagc 2704861 tcttcaggtg tgtatacgtc cgcaaaactc atcaggaacg ttgcggctgc aatcgatttt 2704921 ccgtagcccg aagagccgaa gatgccgata tttccatctt ccatcatctt ataagcaatt 2704981 ggcgcctgtc tttgcagatc aggttcatcg acatacgcaa agtggaaatg gtctttttcg 2705041 tttgaaggga aaagagtgcg cggaatacgt tccgcaagcg gcggcagcca agggcttggc 2705101 agcttctcga ttcccatttc atcttggatg cgttcaattt cgtcaactac agcttcgatt 2705161 tcggtttgaa cgtctttttt cgcgttatct tcggtatcaa cctcagaaag cgggatcaga 2705221 cccgtatctg tgacgatcgc gatttcatcc tcggtaccgt agacttcctc taagtaaggc 2705281 gccccgctcc atgcagattg gaacagctca tacacttcat tgtttccgac ctgcaaatag 2705341 ccgcggcctg ttacggtaat gtttgcggca tcgctgtttt tcaaaatttc tttactgtcg 2705401 gtggcatcct ggaccttgag cgctacttta aagcgcgagt tactccagat ctggtcgtcg 2705461 atgatgccgc ctggcttctg tgtcgccaaa atcaaatgaa cgccgaggct tcgtccgata 2705521 cgcgcggcac tgacaagctc cctgataaaa tcaggctcct cgcttttcag ctcggcaaac 2705581 tcatcagaaa ttaagaacaa gtgaggcatc gccacttctg ctttcccttg cttgtatagc 2705641 tttgtatagt cattgatgtg attgacttga tactggtcaa acaggcgctg cctttttttt 2705701 agctcgcttt taatggaagc aagcgcacgc atactgaagt ttttgcttcc ttcaatattt 2705761 gtgatcgtgc cgaggaggtg gggaatgtta cggaacggct gcgccattcc tccgccttta 2705821 tagtcaatta gtaagaaagc cgcttcatgc ggatgaaaat gcactgcaag tgacaagatg 2705881 taggtctgga gaaattcact tttccctgat cccgttgtcc ccgcaagcaa gccgtgcgga 2705941 ccgtgtgctt tttcgtgaag gttcagatac acaatgtcat ctttcccttt atagccgatc 2706001 ggcactgaca gcgacttcga cgattcactt gtcagccatc tttgctgaat gccgatttct 2706061 tttacttcct tcgcatgaaa aagctccagg aacgataccg tttccggaat ggaattcgta 2706121 atgccgacct ggtggttcag cgtccgcagt gtgcgtgaaa accgttcgtt atcctcacgc 2706181 tgatgatgat cgagacggaa cggaattctt accgcttttt tcttttgtat taaaatgtcg 2706241 ccttcatgct cattaatgta gcggacaaga gttgtaatgt tttccgacaa gctttccttt 2706301 gtttctgcag cgacaattgt cgagatgccc agatgctcat gctgcccttc taaatattcg 2706361 agaatgacat gctcagagat cagctgctga ttcgtgatga caaatacaaa atgcggtttg 2706421 aactgcagtt tttctttgtc atcttcgaga tcacgctctc tgatcaattc gtaaagtgaa 2706481 gacaggagct gatctcgggt ttgctcatta taaataaatc cttttgcata aatatggggc 2706541 atttgaaatt gcggaagcca cttcatccac tcccagtctt tatactcttc ttcatgaaaa 2706601 ataaatacga aacgcaaatc gtgatagctg ttaaagaacg acagctgtcc gattagctgg 2706661 tgaatctcat ttttcacaat ttgtgattta ccgacaagcc ccatcggacc ttctgccaaa 2706721 tcgaccgtca ccggcgcatt acggatatct ttatagacgc gttgcatgtg ctgcgatttc 2706781 tccatgaggt catcgatatc acgattcgcc aagtctccgc cactcatatt gatttcatag 2706841 cttgacggaa ctgttcccgt cccaagccgc agctggagat aatccttgct ttcaagtgat 2706901 ttttcccaga tccggtcact gatttcactt gttaagtatt tcatttgttc aaatgaagga 2706961 aagtgaaatt caagaacctg cttttgcttt tcagcaagtg cctgaagctc tttccgctta 2707021 ttgtctaagt aaagcttata tacacgctcc cgtttttcct cgcgtttttt ccgctggttt 2707081 ttatcacgga aatattgcac tgtcgaggta atgagagtca tcataaacat cgccaaagaa 2707141 acgagtataa atatgccgcg cggctggatg atggcaacta cgcccatcac gatcagcatc 2707201 acaagcggag gcaggatgac gagccacagc cctctgttgg tttgatcgct ctcctgagag 2707261 ggaaaactga aagaaacgcg gtcatccggc agatcgtata ccatccgcgg cgttcttctg 2707321 tactgcggat attttttctg catctctgta ctcggtttga ccgtttctgt taacgctgtt 2707381 tcaaactggg cataatgaac aatttctaaa aggtcttgtt ccgtcaccct catttgcgtg 2707441 aagttccaga atatttcatc ccccggcttg agcggcgtat tggcgttgat tttctctccg 2707501 ttcaagaaga tcgttccgct ttcagggcgg accgaccagc tgccgcctgc acggagcaaa 2707561 gaaaacgtgc tttgttctgc aaatgcaaaa tcttgcggat tcagataaat atctgcattc 2707621 gttttttctg aggaacatac aatttcatcc cgatttcccg taaaataaac ggatttctca 2707681 ggttcactgc ccgtcaatat caagcgtata tcctgctgat ccgtttggag agtaaatgat 2707741 atatccgtct caatcgtgcc gagacaatca tttcccagga aaacttcgta ttggccgccg 2707801 gattcctttc ttttaagaga aatcactccg ctattaaatg gaatggtgct gatcgtaaca 2707861 gaatccttca catcaggccc tatggtcacc ggatgagacg acgggaggtt agacagattt 2707921 aatttttgaa cgttattttg gtaaaaaacc cataatagac tcaaatggcg aaccccctta 2707981 cggccgaatg gcagcatgcg atgacctgcg cttcatgtct cacgttattt gtcatctttt 2708041 ttctcatctt tcttttctgt ttcttttttc tcgtcttctt tttccttctg ttcttctttt 2708101 ttcgcttttt cctcggctgc ggctttttct tctgccgctt tctcttctgc ttgtttttct 2708161 tcgtctgttt gtgtctgttc ttcgcttgta tcgactaacg atgtttcaga attagactgt 2708221 ttattttctt gacgttcttt ttgggctttt tcaagctcac tatttactga atcaagttct 2708281 ttttgtatgt cttcatcatt tgtatcctca gataaaagct gctgtttata tttagctagg 2708341 gcaaagtaaa tataatcatt gtattccagc ttacggccga tactgatcgc ttctttgtat 2708401 tctcctcgac cataatcaat ccaatataag aaatgctgag ggtctgattg aagggtgact 2708461 aaattatttt ctatattttt ggtttttgca ctccccaggt tttcgacctc aacataggac 2708521 gtcgccagct gatactgcac cgattcaggc aggctttccg catcgtactt ggacagtgtg 2708581 ctgatgactt cactgtactg cttgtttaag aacgcacggt tgctgtccac tatcgcctgg 2708641 tgctttggct gcgcgaaaaa taaggcgtac atcgaataaa taagtgccgg tacaagcaaa 2708701 acaatgagcc ccaggccgat atatcgctgg atgttccact tctttctcgg gatatgtatg 2708761 tatgtttttg ctttggcttc gagctcatca atatgggttt gaatcagctc gagcaaatca 2708821 tcataggatt cagcatctaa tatcgccttt gcctctgcgg agaacgtcag cgtttcattg 2708881 aatttcaggt agtcttcaaa cgcaaaagcg ccgtcaactg ccaaagccgc tgccgctttc 2708941 agctcctgcc atactctttc ctcatcacgc tcgtaaggag gaatgctttc ttttactcca 2709001 taatggagaa aataaggcgt aagcccttta tcgaatacaa tgttttcagg agcgacaatc 2709061 aaattcagcc tcgacagatt gtgctgctgt acggcttgaa caagctgata ggcaaactgc 2709121 catttacttt ttttatcctt agctttcatg aagcggaatg ctttatagga ggagggaggt 2709181 tggattgtga tgattacttc atcatccgtc acatcgattt ctttatgaaa aaatggattt 2709241 atatctttga tcacgttagc ttcaagaccg tcgagaagct ttattttttc ccgttgaaag 2709301 gtaaatgtat agccggcatc tgttttctcg gcaacagctt ctaattggtt ttctaaatat 2709361 gatttttgtt cacctgacat tcaaccagat cctttcataa tatttcaagc cggtctccgt 2709421 ttgtaatgcc gcaatcagac agcttgcatt ctccggaaaa caccttatcc ttgttcacca 2709481 ctctgatcca gtgcccttcg cgcggaggca tagatacgct ttgggcctgc caagcaatat 2709541 caattacttt tttcaccggg tggtaatctg acaatctgag atcaaagaca ctgccgttat 2709601 aatgtttcaa atctattgta atatcaatat acatttagga tcacccttac atagaaagag 2709661 cgccgtcttc ttttgaatca ggcgctcctt ccctttcata ctgttatccg cggatttgat 2709721 ttgcgatgtc ttggtcagta gactcaagtg tatttgctgt ttgatcaagc tgctgattca 2709781 catcttgaag caaatctgac attttgataa atgaaggttt gagctgctcg tattgatctg 2709841 cgaacgcttc gcttgaagca ccttcccaca tgcttttcaa atcagagatc attcggttta 2709901 aacgatcaac ctgatttaat acttcttggc tttcaacgcc gtattgcttc gccatcgctc 2709961 ttagctcttc gggtgtgaca cgaattaatc ctgccatatt cctcattacc tcctgtgcca 2710021 tcagcctaaa tatgggctaa ttcacttatt tttagaacgt cattattata aaaacagttt 2710081 ttcggcatag tcaaacaaat atgttttaat tttacaaaat gagtccaatg gtttaccccg 2710141 aatcactcaa aaatgacata tactgtaaag taaataggtt tattttctta atcttctctt 2710201 cattctccga ataatccaaa agacccaaat aactctccaa ctcccaaaaa aaacctttca 2710261 gaaaatttga tgctacagca ccatttctga aaggttcagt tttttctttc cttaattagt 2710321 cttgcctccg atgactttct tagaagatta ataggataag ctgtcgtatt atatgagaca 2710381 tacactgtcc tgcaaaaagg cgattacacc gccaaatgta tatagaacgt ttctctcatg 2710441 aaattgtttt tttgcttctg ttctttgttg ttgattttca caaacaacaa caatcataat 2710501 aaaaggaagg ggatgagatg tcaaagagaa atcaagcacg aaaagtaggg agatttatga 2710561 ccatgccgaa tgatccgttt aaatatagtt ttgacagact tgaagatgtg gctgatcata 2710621 tcagcgacgt tctgcggtgc ccgatcacca tagaggatgt taaccacaag ctgcttgcct 2710681 acagtacaca cagcgactgc acagaccctg cccggacgtc taccattatt ggcagaaggg 2710741 taccggagaa ggtgattaac aagctgtgga aagacgggac aattcctgct ctcttaaaaa 2710801 cggaccagcc gatcagagtc aagcaaatcg atgaagtcgg gctgagcaat cgcgtcgcta 2710861 tttcgatttg gaaaaacaag caagtacttg gcttcatatg ggcgcttgag atccaaaaaa 2710921 cattgtccga tgaagatctg ctgacattgc aaatggcagc aaaagcagtg aaaaacaagc 2710981 ttctcaaact tcaaatcaga aaaacgaaaa atgaagaacg cagccaagaa tttttctgga 2711041 aaatgctgac cggacacatc catcaggagg atgatatggc ggatgggttc cataagcttg 2711101 gaatggccgc tccttcagag ttttccgtta tgatcatccg cataaatggc gagctgactg 2711161 aaaaaatcga acagcagctg caatatttac aggaaacgac ccagcaggtt tacgtgctgc 2711221 tggcgaccgt agattccaat gaacttatta tattaacctc acccaaaaca gatcatcctt 2711281 ttcaagattt aaaacagttt gctttaagta cgcaaaaaca gctgaaggag cggtataaaa 2711341 tagaagacgt ttctatcgct tttggcggaa tatacaactc tatttctttt gtctcccgct 2711401 cctatcagga agcattgtcc gtcttaaaaa cgaaggaacg gttcgctgaa gagaccaaac 2711461 atcttttcag cttttctgag ttaggcattt atcaatactt agatgtctta aatgaaaaac 2711521 ggaaacaggc gggccattat aattactcgc tttccaaact ggaacaatat gaccgggatc 2711581 accagtcaaa tatggtagag acgctagagc gctttattga agcggacagc aacgtgaata 2711641 ccgcttccaa gctgttaaat atacacgtta atacgttgaa ttaccgactc aagcggatca 2711701 gccagatcgc tgaaattgat ttgaaaaatg tgaatcaaaa attcaccatc tatttagata 2711761 tcaaacttcg gcacatggat ttgtgaaatt tcacaaatcc atgttttttt attttcttaa 2711821 tcaaacaaag aattttccaa aatatcaagc tacactaaaa atatcacata tacaggagga 2711881 gacagatatg atcatagggg ttcctaaaga gataaaaaac aatgaaaacc gtgtcgcatt 2711941 aacacccggg ggcgtttctc agctcatttc aaacggccac cgggtgctgg ttgaaacagg 2712001 cgcgggcctt ggaagcggat ttgaaaatga agcctatgag tcagcaggag cggaaatcat 2712061 tgctgatccg aagcaggtct gggacgccga aatggtcatg aaagtaaaag aaccgctgcc 2712121 ggaagaatat gtttattttc gcaaaggact tgtgctgttt acgtaccttc atttagcagc 2712181 tgagcctgag cttgcacagg ccttgaagga taaaggagta actgccatcg catatgaaac 2712241 ggtcagtgaa ggccggacat tgcctcttct gacgccaatg tcagaggttg cgggcagaat 2712301 ggcagcgcaa atcggcgctc aattcttaga aaagcctaaa ggcggaaaag gcattctgct 2712361 tgccggggtg cctggcgttt cccgcggaaa agtaacaatt atcggaggag gcgttgtcgg 2712421 gacaaacgcg gcgaaaatgg ctgtcggcct cggtgcagat gtgacgatca ttgacttaaa 2712481 cgcagaccgc ttgcgccagc ttgatgacat cttcggccat cagattaaaa cgttaatttc 2712541 taatccggtc aatattgctg atgctgtggc ggaagcggat ctcctcattt gcgcggtatt 2712601 aattccgggt gctaaagctc cgactcttgt cactgaggaa atggtaaaac aaatgaaacc 2712661 cggttcagtt attgttgatg tagcgatcga ccaaggcggc atcgtcgaaa ctgtcgacca 2712721 tatcacaaca catgatcagc caacatatga aaaacacggg gttgtgcatt atgctgtagc 2712781 gaacatgcca ggcgcagtcc ctcgtacatc aacaatcgcc ctgactaacg ttactgttcc 2712841 atacgcgctg caaatcgcga acaaaggggc agtaaaagcg ctcgcagaca atacggcact 2712901 gagagcgggt ttaaacaccg caaacggaca cgtgacctat gaagctgtag caagagatct 2712961 aggctatgag tatgttcctg ccgagaaagc tttacaggat gaatcatctg tggcgggtgc 2713021 ttaattcaca ataagcttgc agaaagattt ctgcaggctt ttttattttt taaaaggaaa 2713081 aaagagacca tttcacgaat tatgactatg aagttgatca taaaggagga ttcatatggc 2713141 tgttcagcaa tatggcgtgt taaaaggcat agtattagac atgaagcggg aaacagatga 2713201 tgacagtcct catttccaag tcaaaatgct cggtgaagag aatacgtatt acaggtgcgc 2713261 catcaatgtg atgtccagtt ctgaggaatc tgaagtattg tatttggctg acgatcagtt 2713321 tgattcgggc tcaattacca tccttccgaa catgccgtat ggatatacaa ggatcaatga 2713381 agcaaaccgt gaagtggcac tggattatgt gcggggcaat ttgtttgacc cgcgggaaat 2713441 gaagcctttg cctcatgaaa tcacgggacc tgataatgat ttaaatgatt ttattgaaac 2713501 ctatatgaag aaagcacaag atgagaaaac gccggtttat atattcggtt caaaattcgg 2713561 ccctgaacag gctgcagata aaatattcgg ctttaccccg actaacggaa tgcacaatat 2713621 ccatatgaat caagggaatg caatggatac ccgctggaaa aaagacaacg gctcttggca 2713681 tgacgggggt attctgattc agtttgcaga tcagtgggcc gctgtgtttt tagcgttttt 2713741 atcccaatct tggtgtaccg atgaaaacgg aaaccctgtc agagattgtg atcataccca 2713801 aacgtctgcg taagatagaa aaagagactg cggcaagcag tctctttttg ataagattac 2713861 acattttcaa cagtctttag gctgtttggc ctcatatcgc tccaatgcga ttggatatag 2713921 tccaaacaag cttcacgccc tttttgctca tgaacgactg tccagccgct cggcacatct 2713981 ataaaacccg gccataggga atattggcct tcttcattga ccagcaccaa atatgtgcca 2714041 tccgcatttt caaaaggatt tgccattcta tttctcctcc cttatttatt caactcttcc 2714101 aatttgacag cgagaacctt gccgatttga gccagaggtt caggctgaca taaatcttta 2714161 tgacggcagt cgatgtcgat ttgttcaatc tgtccgttaa tataaggctt ccacgagtca 2714221 ggttcaatcg ggtcaaacca ttcaggaatg attgttgatc tgaaaaacaa aacatttccg 2714281 cggaaggttt tcggcttata ggaacctaaa atgccgacag aatttacata cgtattcttc 2714341 aaatttaaaa tgaccgtttc atccaggctc gcaagcgcac tgccgtcacg gcgaagaatc 2714401 tcaatcgccg cttcaaaatc tagcggtttt tcccctaagc tgtctggatc atacccgcct 2714461 aacgccagaa gggcaataag cgcttcctca tcatccggtg cctcttttat aggaaggaag 2714521 tggttcggat aggcgtccag catcaccaac agggatactt cttctccttg attttgcagc 2714581 tgggtagcca tcgcttgaac gacattcccg cccagggacc agcccagcag atggtacggg 2714641 ccttttggct ggaccgttcg gatttgttta atgtaatcgg cagccatgtc atcaagtgtt 2714701 ttcggaagct cctcgcgctg cccgattccc cgtgcctgca agccgtagat cggataatct 2714761 gttcctatat tggtcatcaa accggcataa caccagctga gcccccctgc cggatgaaca 2714821 cagaataaag gaggcttgtc tccgcttgtt cggagcggca gcagaacgtc aagagcgctt 2714881 tggcttgatc ccatttcaag tctttcagcg agcccggcta cagtaggtgc ttcgaacaag 2714941 ttgccgatgc tgagttcaac gccgagcgct tcacgaatgc ggctcatgag ctgtacagca 2715001 agcaaggaat gtccgcctaa atcaaagaaa cggtcatcaa tgccgacacg cggcaagtga 2715061 agcacctcca taaagaggtc acagagaatt tcttcctgcg gcgttctcgg tcctcgtcct 2715121 gtcactgccg ctgcgaaatc cggagcgggc agcgctttac gatcaagctt tccattcggt 2715181 gtcagcggca attctttcat cgtcacaaag gcagcaggca ccatgtaatc cggcagtctc 2715241 tcagcagcat atctgcgcag ttccgccgta tcaaatgttt cttccgaagg gatgacataa 2715301 gctgctaacc gtttatctcc cggctgatcc tcacgaacga tcactgccgc atcttcaagc 2715361 tgcggatgct gaacaagcgc ggcttcaatt tctcccaatt caatccggaa tccccgaatt 2715421 ttcacttgat ggtctgcacg gccgacatag tcgagagaac cgtcagcgcg gaggcgggcc 2715481 acatccccag tgcggtacat ccgggtgcct ggaggaccga acggatcagc tatgaagcgt 2715541 tcagatgtta aaccaggccg gcctagataa cctcgtgcta accccgctcc tgatacatac 2715601 agctctccgg caacacccgg cgggaccggc tgcaggcgtt catccagcac gtatacacca 2715661 agatcgggaa tgccgcagcc gatcaagctg tttgcccgta aagctgccat gcttcggtct 2715721 aattcgatat agctcacatg caccgtcgtt tctgtaatac catacatatt gataagctgc 2715781 ggtctatttt cagggtggcg gttgtaccaa tcctctaaac ggctgagttc aagcgcttct 2715841 ccgccaaaaa tgacatagcg cagactgagt gcctgtccga gatccggctg ttcccgttcc 2715901 gcctgcataa actgatagaa agcagacggt gtctggttca gaacagtcac cccctctttg 2715961 acaagcaggc gcagaaacgc ttctggcgat ctgctgacgt ggtgaggcac gattacaaga 2716021 cgtccgccat gcagcagagg accccagatc tcccacaccg aaaaatcaaa cgcataggaa 2716081 tggaacatgg tccagatatc acctgagctg aaacggaacc agtgctcggt cgctgcaaat 2716141 aaacgtgtta cattttggtg aggaatcatc acaccttttg gaacacctgt tgagccggat 2716201 gtataaatga catatgccgt attcaaaggg gaaagcggct gagtcctatc cttatttttt 2716261 ggattacctg cagggtacgt gtttagtttc tctgccagct cgggatcatc cagcacgatt 2716321 ttcggcacgt tttcaactgg cggaatgtga tttgcagctt tagtgttcgt catgataaac 2716381 gcaggctgtg catcttttag cataaaagca attcgatcag ccggataatc cggatcaaga 2716441 gggagataag ctgccccggc ctttagcacc gccaataggc cgacagccat ttccaacgat 2716501 cggggcagtg ccaatgccac aaattgctcc ggcccgacac cttcactaat catcattcgg 2716561 gcaagccggt ttgctctttc attcagctct gcatagctca gttcctgatt ttcatataca 2716621 acggcaatgg catcaggacg taaagcagcc tgcttctcaa attgctctgg caaacatgcg 2716681 tgcggaatct tttcagatac actttgccaa tcagtcacca tgctgctgtg ttcctctggc 2716741 gcaagaatat ccagatttcc gatttgctcg tcaggatcag actcggcagc ctccaacagg 2716801 cgcatcaatc ggtcagcaag agcctgagca gtttcccgtt tgaaaagatc agtgctgtat 2716861 tcaagcagtc cttccattcc gtttggtgtc ccgtcagcaa ggcgatcttc actaatttcc 2716921 agcgtcaaat caaacttggc agaaccgaca ctgttgattc gcaggctgct ctccatatca 2716981 ggaagatgca gttcagcgtc cggtgtgttt tggaacgcaa gcatgatttg gaataaagga 2717041 tgcgtcgcac gcgaacgagc cggattgagc acctctacaa gtctctcaaa cggcagatcc 2717101 tgattgtcat aggcggccag attcacttcc cgtactctgt ctagaagctc acgaaagctt 2717161 gggtcaccgg acgtatcagt tctgagcacc aatgtattaa tgaacagccc tacaagatcg 2717221 cccagcgcat catcattccg tcccgcgatc ggactgccga tcggaatgtc ggtgcccgcc 2717281 ccgagccttg tcaataaagc ggcgagaccg gattgaagca ccataaacag gctcacccta 2717341 tttgcgcgag ccagctcctg caatcgcttg tgaaactcgg gctcaatacg aaaatgaatc 2717401 gtatctccat catgactcgg ctcagccgga cgtgaataat cggttggcag ttcaagctga 2717461 tcaggcaggt ttttcaaggt ttctttccag aaagcaagct gtccggcaat caagctattt 2717521 ggatcatcct cgtttccaag cagttcttgc tgccaaagcg catagtctgc atactgcaca 2717581 gcaagaggcg cccattcggg agatcgtccg tggcagcgag ccgcataagc tgtcccaagg 2717641 tctctggtca gcggtgttaa ggaccagccg tccccgacaa tatgatggac gagaagaagc 2717701 agcacgtact cgtcaggacc gatcacaaaa agctcggcac gaaaagcagg ttcagctgca 2717761 agatcaaagc tgtagcgtac agcttcggca agccgatcag aaagctcctt ctcagcaatt 2717821 tcagtaacat gtaactcggg acaggctcga tcggcatcta aaatatgctg ataggatgtc 2717881 ccctgtgatt cagggaagat cgtccgaaga ctttcatgac ggcagacgag gtcataaagt 2717941 gccgctttca gcaatccttg atccaactca cctgacaaac ggacagcaac cggaatatta 2718001 taagtaggac tcggtccttc cagacaatgc aggaaccata gccggcgctg ggcaaatgag 2718061 agcgggatct tttcaggccg ctcagctctc tgcaaagcgg gacatgcact ctgcgccaaa 2718121 tcaagatggg cagcgagtcc ggctactgtc ggttcgtcaa agagcttggc gataccaagt 2718181 tcggctccca ttacctcgcg aatgcggctc atcagacggg ctgcaagaag agaatggccc 2718241 ccaagctcga agaaactgtc atcgataccg acgcgtgcca aaccgagaac ctctgcaaac 2718301 aagtcacaca atatctcttc ctgaggagtc cgcggggccc gatcactgac agatgtgctg 2718361 aagtctggtg ccggcagtgc tttccggtca agcttgccat taggtgttaa cggcagctcg 2718421 tccatctcca caaacgccga cggtaccata taatcaggaa gactagcccc catataacga 2718481 cgaagctctg cagtatcaat agcagcatca gcgactacat aagccgccaa tcgtttgtct 2718541 cccggctgat cttcccgtac gacaaccgcg gcctgttcaa tgtgcgggtg attggcaagc 2718601 acggcatcaa tttctccaag ttcaattcgg aatccgcgaa ttttgatttg atgatccgcc 2718661 cgcccgatat aatccaaaga cccatcggcg cgccagcggg cctggtctcc ggtccgatac 2718721 atccgagttc ccggcggtcc gtatggatct gcaacgaagc gctccgccgt taaatcagga 2718781 cgatggaaat aacctctggc caagccggtt cctgcaatat aaagctctcc gacaacgccc 2718841 ggcggcaccg gctgcaatcc attatcaagc acatacacct gcgtgttcca aatcggtttc 2718901 ccaatcggag gaacgccctt cagcccttct tcaagaaaag ctgcggcaga ccaaatcgtt 2718961 gtttcagtgg gaccgtataa gttcgtgact gaacaatgaa ggtcttgaag ttcctgcaaa 2719021 agaccgctcg gcagcgcctc gcctcctaca agcactctaa gcccccgaag tttctcaggt 2719081 tcactcgtta ccaaagcgtg ccacagtgtc ggtgtcgcct gcataatgtt aatatcgaaa 2719141 ttttcaatca tttgagctaa tgcctgcggc tcacggatcg tttctttctt tgcgatcacg 2719201 atttgcgctc cgctaatcag cggaagatat aactccaatg ctgaaatatc aaaagcgaca 2719261 gtcgtcacag ccaacagcct gtcttcttct cctagagaaa atgcctcctg catagacagc 2719321 agaaaattgc ttaagctttt ctgtgtcaca acgactccct tcggtcttcc tgttgatcct 2719381 gaggtataga tgatatacgc aggatggtca agcgaaaccg atacatcctg attttccggc 2719441 gaatagcgtt ttataatctc ctgtgtaaca gcctgatcaa gcacaagctc aggtacagcc 2719501 aggtcatcag gcagactggc tgctatttcc tcagtcgtta tgatgcatga aggtttcgca 2719561 tcctccagca tgtaagaaat gcggtcggct ggaaactccg gatcaagggg gagatacgcc 2719621 gcaccagtct tgagcacacc aagcattgaa gccaccatct caggggaacg cggcagcgcc 2719681 aaagcgacaa attgctccgg accaatccct ttttcgatca acagacgcgc gaggcggttt 2719741 gcctcttcat tgagctttcg atagttgact tgaatgtcat cacacatgag agcgatacgt 2719801 tctggcgtaa gaactgcctg cttttcgaac atgtcctgaa ggctgaccag cttctcggat 2719861 tttgccgtct cattccattt agaaatgact ttttctttct cctctggcaa cagaagctcc 2719921 atttgcccaa tcagcatgtc ctctccggca gaagccgttt gcagcagctg caaaatacgc 2719981 tgctgatgaa gcttaatatc agactcactg tatacctcgg gattcgcatc aacatcaatt 2720041 cgcagcccgc tgccgtctgt tctgtcatat acattgattg atagatcatc aacaggaccg 2720101 gctgaaagat tatgcgttgt gccccggacg ccggcaaagt cgagaccgta atcaaacggc 2720161 ataagattga tttgagggcc aaataatcta tgattttctc ctatcaattt cagatcgcgc 2720221 ctaagctctt catggcgata cttatgatgt cgccgaatac tgcggatttc ccgggaaatt 2720281 tgctgaatca gttcagaaaa gctcatcgaa gagcttaccg tcagccggag cgggagaagg 2720341 ttcatcacca tagccggtac attcagtgac gcggacccta tccgacccat catgggcagg 2720401 ccgagcacaa catcctcaga gccggtcata cggtgcacat aaacagctga caccgcaatc 2720461 atgacttcat gccagcttcc tgagaaatag cgcgccgctt cttttaacgc gtttacatca 2720521 gacggaggca gatatgccgt atgacgaaga aaactgttag atgttcttgg cgcccgatca 2720581 gccaagctca caacttcagg tgcatctgca aaacggtcca gccagaattg acgatccttc 2720641 tcatactgct ctgatccgcg ataatctgta tcctcctcca aaatggcctg gagagaccca 2720701 aaggaacggc ttttagctgt ttgtcctttt ataagggcag tatatgtact tgccacacgc 2720761 tgggctatca gggaaaaacc gaagccgtcg atcgctatat ggtgaatgcg ctgataccaa 2720821 aagaaacgat caggcccggc aataaacaga gcttcattga acaaaggggc ataccctaaa 2720881 tcaaccggct ttgctaaatc agctttcatc cagtttaatg ctgttttttc cggatcaggc 2720941 tcagagctga cgtcaatgac gtgcagctgt acatccggag acgggtttat catctgccaa 2721001 ggcccgtcca tattttcacc gaagcggaca tgcagcgatt ccgcttcctt gatcacgtgc 2721061 cgcaaagctt cttcaaaaag agcaatattg actggtccat tgatttctat atattccgct 2721121 gtattgtaga ttggattgtc cggatcaagc tgctgagcaa accatatgcc agtttgcgcc 2721181 ccggtcaaag aatattgaag atcttttgta tcaggcatcc gtttgtttac cctcctttta 2721241 taaataatcc gcgtttggca gcacttgctg gctgcgagtt gtgagcaatt tctgccattc 2721301 ttcgatcgtt gggcgttcag ccaattccac gaaagtcacc tctgcccctt cacggcgcca 2721361 ttgttccacc aatgtcatga tccttaccga atcaagacca cgatcgagca aatcctcttg 2721421 atctgtgatg tcttccggtg tttcttgtag aagctcagca atttgtttac ggatattctc 2721481 acatgtaaac acgttctttt tgccagtgtt tgctgacgtt ttttgaacgt ctgccggcgc 2721541 attctgcagc tgatcaagaa gactgtcagt catcacggta aacgcacagc gtccagccgc 2721601 atattccagc gccatttgat gtttttctaa tgaaaaatca gcaactgcat ctcccacaaa 2721661 aaaggcttta atatcctcca taaatgcttc acatgctgta acaagacagc cgatatgggc 2721721 gtaaattcct gtaatgatca gctgatcgcg tccctctttg cgcatcattt caagcagatt 2721781 cgttctctta aacgcgctgt atctccattt tgtcagcaca agatcatcat cctctggtgc 2721841 cagctcggtt ataattttct cctcataagg accgctgttt aatcccgggc cccaaaagtc 2721901 tgtcagcagc gcacggtcat ccggattttg gcttcccggc tgtgcggtat agacaacagg 2721961 aatcccaagc tgaacacatt gattcttcag ctttcgtata ttcgctgaaa gctctgttac 2722021 cggagacgct cccgctgtga aagcatcaac aaaatagttt tgcatatcgt gtattaacaa 2722081 gacagcccga ttcggatcag gcacccatga tactttgttt tgcggcatat cagatgctgt 2722141 cggcatttga tacggctgaa tggcaggtat agccatatga acacttcctc tcaaattgtt 2722201 gttttatttt ttaaatcctg caagaagctt ctcggaaatg gcttcacgga gcgctttttt 2722261 gctgactttt cctactcctg tctgcgggaa ggattcgaca aattcaactc gatcagggat 2722321 tttatatgcc gccagtccgc gctctctcaa aaatgcttta agctctgcgg cttttggggc 2722381 ttcatcccgg ggaataatga acacacaaga tctttcgcca agaaattgat caggcatgga 2722441 gaccattgcc gcatcatgga cagccggatg cgccagcaga tgattttcta cctcttcagc 2722501 cgcaaccttt tctcctccac ggttaatttg atccttcgcc cggccttcaa cgacaatata 2722561 gccgtctcgt gtcagcctga cgatatcacc cgtacggtaa aaaccgtcct cagtaaatga 2722621 agcggcgtta tgctcttctg ccttatagta acctcgaatt gtatacggcc cccgcgtcag 2722681 cagatggcct gtttcaccag gttttacgtc gcgatcatga tcatcccaaa cacgcatttc 2722741 atcatatgga gacatcggtt ttccttgggt gttgacaatg atctcctcag gatcatccaa 2722801 tctcgtataa ttgacgagac cctctgccat tccgaacacc tgctgcagcg tgcagccgaa 2722861 aacagctttt accctgcgcg cggcttcagc actaaacttg gcaccgccga cctgcagcac 2722921 ttgaaggctg gataaatcat cacggcgtga ggatgccgca tccatccata ccatcgcaag 2722981 aggcggaaca agagcggtta tcgtgacctt ttcccgttca attaaaggaa atgcgtcatc 2723041 tggacttgga gaaggagata ataccactct tcctccagcg tataatacgc cgagaacgcc 2723101 gggtgagctc agcggataat tgtgtgccat cggcagcgcg gccaagtaca ccgtgctgtg 2723161 gtcgagccag cagacctcca cactccgctt caggctgtat atgtagtcat cgtgggtcct 2723221 cggaatcagt ttcgatagcc cggtgctccc gccagaaagc tggaggaacg ccacatccga 2723281 tgatttgact tcaggcagtt ttacaggttc tgcatgcaaa tcctccagcg gtaaaaattc 2723341 ctctgcctca cctgcgacaa tgatgttttt caaagtcggc agcttgcttt gaacctgtct 2723401 ggcaagcgaa cggtagtcaa aaccggaata agcgtcggga atgatatatg cagccgcttc 2723461 agcaaactcg caaaaatatg taatttcact gcttcgatga gaaggcagtg cgaagactgg 2723521 aagcgccccc agacggaaaa gcgcgaaaat gacttcaaaa aactctttga tatttggcaa 2723581 ctgcaccaca acacgatcca tctgttgaat gccgagcttt tgaaatccgg cagccaggcg 2723641 atcagccctt gtgtcaagct ctcgatagct ccaatgggtg tttccgcatg taatggcaat 2723701 gcgatcacca tatttggctg cccggtccct taacaaatct ccaaacgtct caccggccca 2723761 gcagccgttc tttcgatagg tctcagctaa ctcatcaggc caaggcgtaa atcctttcag 2723821 catgttgtat ccctccagca attcattctg ttcatatgtg atccacgccc attgcccgca 2723881 gcattgtccg aaactttgcg gacgtctcct gaagctcgtc ctcaggcttt gaaccggcca 2723941 caacaccagc tccagcatac aggcggagtg agcgttcttc tgcttctgca caacggatgg 2724001 tcacgatcca ttctccgtca ccggcatcgt cacaccatcc gaccatgccg gtaaagaaac 2724061 cgcggtcaaa tggttcaatg ctgagaatcg cttctcttgc aagatcagtc ggtgttccgc 2724121 agacggctgg cgtcgggtgg agcgccgccg ccaattcaag tgcggttaca gacgggtcgg 2724181 aaagctctcc cttaatcacg ctggacaggt gccacatcgt ttccgttttg atcagtgaag 2724241 gcttctccgg aacctccagc gtccggcaga aaggtctcag cgctgccgca accgcgtcag 2724301 cgacaaccgc gtgctcatga agatcctttg cggaagaaag caattcagct gcccggcgct 2724361 ggtcttcaac aggatcatta ctgcgcggtc ttgagccggc taatgggttg gaaacgacct 2724421 gtgttcccat ccttgaaacg agaagctccg gacttgctcc gagcaatgtt ctgcggggag 2724481 acgtttcctc ctgactggac acgtctgcgg caaacgtgta gccatgcgag ttatgctgag 2724541 ccagatggcg aagcaattca tccgtctgaa tcggttcagg cgatgtcaaa tgcagcgatc 2724601 tggacaggac gattttgctg agtgttccat cggcaatgcg tgccagccct tgttcaacac 2724661 catttttata atcctcaggt tcaggaacag gctttatgtg gtatgtatgc ccagcctgct 2724721 gttccttttc ctcatgatca aattgaagcg gtcctgacca gcgcacttct tcaggtacaa 2724781 cgagccgcgc tgcttttact tgatcaaaag gaacggcccc gacaacaagc ggccggcttt 2724841 gccctgattg ttttgcctga cgtaacgcct ctgcaattcg gccagaaagg gtttccattt 2724901 ggttttgccc gtctgcctcc ggtacaattt cacatatgcc tttcgctaac agtacacgat 2724961 gaggagacgc taagaaaaag gcgcccggct gatattcatg aagcaaatgc tccgcttttg 2725021 tttctgttat aacgttttga tccaacattc tcatgaacct cctttaaatt cagttacacg 2725081 cctaaggtcg cgccgccatc tacgcataaa ttatgcatcg taatatgccc tgcctggcca 2725141 gaaaccaaaa agagcaccgc atccgcaata tccgaaggct tggctagttt tttgagcggg 2725201 atccctgttt taaatgtctc aagtgatcct tttatgactt gctccgctcc attctcgtcg 2725261 gcccataatg accactgcat gtctgtttcc gttgatccgg gagatacaat gttgcagcga 2725321 atattgtatt ctgcaagctc aaggccaagg catttcgtaa acatcacagc cgcagccttt 2725381 gaagacgcat atgccgccat agatgttctt ggtacaccgg cagcattcga tccgactgtt 2725441 acaatcgaac ccgatcttcg gtccatcata tatttgctga ctgaacgcga ggcgttaaat 2725501 acgccagtcg aattcactga gaacgtcgcc tcccattcct catcgctaag cgaatggatc 2725561 agtcccgggc gaaggacacc cgctacattc actaaaatat caatcggccc catttcacgt 2725621 tcgatgcgcg ccgtgatctc gtcaatcgcc gcgctgtctc tcacatccgc aggaaaagct 2725681 tctgcatggc ggccttctgc tttgaggctg ctcacaacct tttccagctt ttcaggatta 2725741 taatcaactg ccgcaatatg tgcgccttga ctggcaagcg tccgcgcaac agcttcgcct 2725801 attccttggg cagcccctgt tataaaagca atttttccct ctataccctt tgcattcata 2725861 tcatcaattc ctttcttcgc tctaaatgcc aaacagacat ccagcgaaaa agactgctgc 2725921 gccttgaaaa acgcaatcta ttgataatga ttatcattat caattataaa aataatcata 2725981 tccaaatgtc atgtgacagt caaatataat ttcagtgaca aatatttttt taaaggcaag 2726041 gctgagtatg tctcagccca ttgatagatg cggtccgtca gggtgaagcg caaaacgcag 2726101 cgccctgctg accaaaacag gaagaactga aatatgtcct tctcctgaaa actcgcaaaa 2726161 ttctgcccgt ataccttgtt cagataaaac ggccagccgc tcataaagct cccttgcatt 2726221 atcattcatc cggcttttat gatgctgctc taattctcct gcggcaagca ggatattgat 2726281 aggctgattg tttttcttgg tgagagagac gaaatggtcc gttttcttga gaataaacgg 2726341 tttattccaa tgaatggacg gacttcccgc gatatacgtt tgaaacgcat cgggctttgt 2726401 tagcagcacc tgcagcacga aaagccctcc gagcgaatgg ccaaagattg tttgtctttt 2726461 tttatcaatc tggtaatctc gttctatctc cggttttaaa tcctcttcaa taaatctgaa 2726521 aaagccctcc gctccgccat gctccggcca ttctctgccg tcgggccttt ccggcagctt 2726581 cgattgggct gttggcattg taaaatcccg gtggcgtgct gaggagaacg gctccgctgt 2726641 ctcatagcca atgccgacga tcactgcagg gatcaccccg gttttttcgg gtcggcgtcc 2726701 ctgtattcga acggcttccg tcatcgttcc gaagacagaa ttggcatcca gcagataaat 2726761 cacaggataa ccagcgggtg gcggcggcgt actaggtttc gagataaaaa tgtgataggt 2726821 acggttttca ttgcgtgaag acatcatacg cacttccgta ccaggaatcg taaatgcgtt 2726881 tgatgtcccg ccatttgtcc ggtctgttgt ttgttctttc atgcagtacg acattcctct 2726941 ccttaaacta aaccgcaatg tatgataatg attttcacta tcaactagac acctcaaata 2727001 ataggttttc ttccaaagaa agtcaacttt ttcccgaata aaaaaggcac cttgatcaaa 2727061 taaggtacct gcagactatc aatatggaag taaaaaccta ataaagatgc gtattgtcct 2727121 atttgaaata gaaccttaat cccatgtaaa cctttgattt tgccaagggt cgcctctcat 2727181 gtgatagcca ttccgctccc aaaagccagg gtgattttct ttcgtaaatt ggatgccgcg 2727241 cagccacttg gcgcttttcc aaaaatacag atgcggaaat acaccccgca gcggaaagcc 2727301 gtgttcaggg gttaaaggtt cgccattatg cgcataagcc agaagggaag tttccgctaa 2727361 gaaatcatca agcggcagat tggtcgtcca gccctcttca gcatgtaaaa tgacgtagcc 2727421 cgcttcttct tttacacccg ctttttccgc tatatcacaa gcccgcacgc cttgccacac 2727481 attatcaagc cttgaccatc ccgtgacgca atgaatgtcg tttttcgatt cataccgtgg 2727541 aaaggctttg acatcttcaa agcttagcag catcggatgg tcaaccaaac cgtatacttg 2727601 aagattccat ttcgtcatat cttcgtaata tgggacatct ccggtatgaa gcacaggaaa 2727661 tgaagtggtg acgttttgat ttggcggcac tcttccagat tgatcggact gtcttgtttt 2727721 tccgaaatac atatgggcct cctttttgtt aacctaattt aaaatcatgt tgacaatctt 2727781 tttgttcttt attactctat gattgtgtat gtcaacctaa gggggaacaa cgatgaaaca 2727841 acgtaaactt cgtgcgggag atatggcgct gattggcatg ttcgccgcac ttatggctgt 2727901 cggggccaac attacatcag tagcaccctt tttacaagta gccggcattc cgctttcgat 2727961 gcagccgttt ttctgtctct tggcagcttt gcttcttggc agcaaacggg cagcgattgc 2728021 catgattgta tatgcacttg tgggattggc cggagcgcct gtgtttgctc aattttcagc 2728081 aggcttcgca ccgtttgcag ggaaaagcgg cgggtttatt atctcataca ttccggcagc 2728141 atttgcagcg ggatggtttt tagaacgaaa cattcagcca agtaaaattc gatttctcat 2728201 tgcttcactt atcggaacgg cgatcatgta tctcatcggc actacctata tgtatcttgc 2728261 actgaagctg tggattcata cgccagtgag ctacggcacg gcttggggct ttatgatttg 2728321 gtttatggta aaagatacag cgctggctgt gatactgtcg tttatcgcac cagcaatcta 2728381 ccgctctatt cataaagcaa ccggctttaa cagaaatcac atatcatcta cgtaaaaacc 2728441 gttctattgg acggtttttt tatcataacg agaaaaggct ccccagtaaa ggggagcctt 2728501 tttcctataa aacaagcgct gcaatccagc caaagatgac aagcggaata ttataaaata 2728561 taaatgtcgg cacacaagta tcccaaatgt ggtgatgctg gccgtccgca ctcaaacctg 2728621 aagtcggccc aagcgtactg tcactggcag gtgaaccggc atcgccaagc gcagcagcag 2728681 ccccgataat cgcaatcgtt gccatcgggc tgaatccaag ctgcatgcat agaggcacga 2728741 aaatggttgt gataacagga atggtcgcaa aagaagatcc gatccccatt gtaattaata 2728801 agccgacaat gagcatcagc aatgcgccca aggactgact gtgtccgata aaaccagctg 2728861 acgttttgac cagtgactcg acatctccgg ttttcgtcaa tacgtttgaa aatccggctg 2728921 caacaagcat gacaaagccg ataaaggcca ttaaaaccat tccatcagta atcagtgagt 2728981 ccgcttcatc acgcttcatc acaccgctga caaacagaac aatcagacca gcgagcgccc 2729041 ccataatcat tccttctact cccaaagtct gagataagta aagctggacg ccgagtgaca 2729101 caacaatggc tagaaccgcg ataccaatac tttttctcgt atatggcgat gcttctgcac 2729161 ctgaaatgtc ttttgtttca tattgtttcg gtttacggta tacgatcact gataaaataa 2729221 ggccgacaac catacctgca actggaataa tcagtgcgta cggaatatca gcaagcggaa 2729281 cgtttaaccc ggcatccgcc atattgtcct tcagcatgcc ttggaagatt tggccgaaac 2729341 cgaccggaag caaaatataa ggagccgtta agccaaatgt aattacacac gcgatcagac 2729401 ggcggtccat ttcaagttca ttaaagattt tcaaaagcgg cggaatcagc accgggataa 2729461 acgcgatgtg aaccggaacg acgttttgcg aaaaacaaga tacaattaaa ataatcagca 2729521 caatcagcac cttagacagt gctttttttc gagaatcttc tttatttccg attaatttaa 2729581 cggaggcttc caccattgcg tccggaagac ccgttttcgt caaagcggcg gcaaacgcgc 2729641 caagcatggc atagctaact gcaacggtgg catttccgcc gagaccgtct gtgaaagctt 2729701 taaccgtttc gccaagaccg agcccgcctg ttaacccgcc ggccaaggcg cctataatta 2729761 atgcgataac aatattgaca cgcagcaggc ttaatacaag cataagcagg actgcgatga 2729821 cgactgcatt catgatgata cccctccaaa aatcctttag tttgctaatg tagtagataa 2729881 ataaagtacg aacgtatcgt atcataaccg atccacttta gtcaactaaa gatttcggaa 2729941 gaaaaaatcc ctgccgcatc atacagcagg gatttttcat tactcgtttt tatcttcttc 2730001 caatgtaaat cgctccgcaa gtgtagccag tgttcttgcc ataacgccag tagccccggc 2730061 cggtccgaag caggttgctt tattggcagt cgctgtgcct gcaatatcaa ggtgaaccca 2730121 aggtgttgac tcagcgaatt caccaagaaa cgttcctgcc ataatcgcat gtccctcgcg 2730181 tcccggtgaa ttgctgagat ccgccatttg gctgcttttc acgcgttttt tatccttctc 2730241 tgttatcggc agctgccaga tcgcctcgcc gcactcttgt gcagcatcag ctacctgctg 2730301 gtaaaagctt tgatcatttg tcattgcacc ggttgtttct gttcctaatg ccacaacgac 2730361 gccgccggta agcgtagcta catcgacaag aactgatgcg ccatgctgtt tcgcgtatgt 2730421 aatgccatct gcaagcacta gccttccttc agcatccgta ttaaggattt ctattgtttt 2730481 tccgcttaaa gatacgatca cgtcatccgg cttcatggcc ccgccggaga tcatattatc 2730541 ggttgatgga ataacgcaca gcacgttttg ttcaggacga agctctccga tcgtttccat 2730601 agccccgaga accgcagctg ctcctcccat atctgatttc atgccaacaa ttccagattt 2730661 cgttttaatg gagtagccgc ctgtgtcaaa ggtaattcct ttcccgacta gtccgacgac 2730721 gtcttcccat tcctttttgc cctgatattt caacacaatc attttcggcg gttcggtgga 2730781 gccttggttt accgcaagta ttccgcccat accgagctct tccatctctg atttctccaa 2730841 tatctcacac tcaaaatcat atttcgccgc aagctcttca gcatacgaag cgaggtcagt 2730901 cgctgtcagc atgtttcccg gcatattcac aagcgttcta gccgaatttg tcccttgtcc 2730961 gtatgcctgg ccgacgcgaa gccctgcctg cacttcctgt gtatcttcat ctgttacaac 2731021 atacacggct tcaatttgtt tgtcaggctc atttgattta tgcttataat cctgcacctc 2731081 ataggaagca agcaggcagc tctcagctaa agcatgagcg gcatcggctg gaggcacgtc 2731141 ttccgaaata aacgtatcaa gcagaacagc agtttcttgt tttcgatctt tatgaatggc 2731201 ttgaaaaaca tgagcaaaac gttccttcgc ctgttcaaac gaataatttg cttctctccc 2731261 caggccaacg aaataaatcc gtttcatacc cgcagaagat ggagggaata cttttgatac 2731321 ttgattcggt ttcgcagaga catcaccctc ttttaaaagc tgtgtcagat ggccttcgag 2731381 catttcatca atttccaacg cttttcctgt cagctggctt ttttgaaaaa gcccgacaac 2731441 aagggtttct gtatgctctg attgttgaac cgcataaaac atgaggctta cactcctaac 2731501 gtaatgggta tttgtaatga acaatggtat aataggaaaa acattctttc cactatactt 2731561 attttaacaa acaacagtct aagacttgct tttttctttt gaaacacgaa ggatttttca 2731621 aatagaaagg atgtcgccga tggaactttt aacgaatttt cctttattat caagcctggc 2731681 cgcaattatt tttgctcagg tcatcaaagt gcccatacag tttatcgtgt ccagaaaact 2731741 ggactggtcg ctggtcacaa gcacaggcgg catgcctagc tctcactccg cagcggtcac 2731801 tgcgctttct acaggcgtag ccttggagca tggattagac tcctcactct ttgcggtttc 2731861 cgccattttc gccgtcataa ccatgtttga cgcaactggc gtcagacgtc acgccggtga 2731921 gcaggcaaca gtcattaata agcttgttat tgattttaac cgtttcgtaa atgaagcgaa 2731981 ggacttccct aaggctgcag agaaagaaaa gcaaaaaaag ctgaaagagc ttctcggaca 2732041 tcagccgatc gaagtctttt tcggaggatt aacaggtatt ttactgacat tggtactcgc 2732101 ttactttttc atgtaaaaaa aacgctcctg ctttcgctgg agcgttttat tctttcaccg 2732161 ttttatattg atttctgaac acttgcaaag attttgtttc attgagcttc tcaagctcat 2732221 cctcggtaat ctttcccgtt ccctttttaa tcacatatac atcaagggtt tttttgcccc 2732281 attcattgta tacatctttg actgtctcaa agtacagatc aaggcggttt cccttaatag 2732341 ctgatcctgt gtcggccaca actccgagac cgtagttcgg aatgaataaa attgttccga 2732401 tcgggaaaac ggacgggtca gcagcaaccg tggaatataa atcccgtttc actttcacac 2732461 ctgaatatgt aagcccgtat aatggatcac cgggattttt gcccgtcgac tcagctcctg 2732521 ctgtgtagcc tgttgctgtt actctttgga ctggatattc atcccaatca aatgcctctt 2732581 ctaacggttt tgttttatcc tcagccgcgg acgtggtttg tgtttgtttc tgctgcaatg 2732641 cttttaatct cagtcctgca tgcttcaagt gcttttcctg atgttcctgc acccattttg 2732701 acaagtcctt cgcttcaatt cctgacactg ataaaaatgt cgtgccaaat gcaagcagaa 2732761 ataaacaggt catcagcaaa cgtctgatca tattcaacat cattcacctc tcctccgaat 2732821 cattgttccc aagtggagag agcattattc aaaatggtga atgagctgaa cgcataaaaa 2732881 aagctttctt tagaagaaag cggcatttaa aacatttgat atcctctttt tctaagcatg 2732941 ttgatcgcta taccggacac gatggcgccg gccaaaccgc tgactaaaat cagcacatca 2733001 gcagccgcta atgataagac acgatgaaac aggctggcaa aggattctcc cggcgactgg 2733061 acatagctga tcagcttttc tttgctgata atgaaaaggc atacaattgg ataaatcaca 2733121 gccataatcc aagacattct cagcagcatg tttaataaga aaccgattcc aaaaaacaag 2733181 acaaaaaaca aaacaattga gatgattacg actggcagac taatcaacct attccacccc 2733241 cctgcgttgt ttttagtgta acgcgggggc tgaaataaag tcaacggctg gaaaaagaat 2733301 gactgtcttt tcctgtcccc tggcaagacg gacaagtctc tgaaccgccg agaatcaatt 2733361 gaaaatatcc tttccctgaa caaaatgggc atgcatgtga agcggttgtc gttgcagttt 2733421 tcatctaatc atcacccttt ttcttaattt tctgataata taccatatca agctgtcaac 2733481 aataaagtca gatcatgtga caaatctttt gatgtaagcg gaaacatact tgttttcctc 2733541 tcgttctctt tttattttgg cgttttttaa taaagaaaac ccgcttccgc gggtttttag 2733601 aaaaacttga acttgccttt tttcaatgtc agtccgagtc cgccaatcat aaacagtgag 2733661 cggttatcaa tgactttttt cataaacgaa gcgggcgtgc ctttcagctt tctgccataa 2733721 acaaccccaa ccgcgttatg ctcgccaaga gaagccactg ttcccttaat gtccggcttg 2733781 aattcctcaa gctctccgcc tttaataagc ctgccaaggt ttttagcgac cgttatgccc 2733841 tgctgcattg caatttgcgc agtcggcgga tacgggcgct ctgtatcttc attcataaac 2733901 agcgagctgt cgccgagaat aaagacattg tcatgtcccg gggcgcggag atcagggttg 2733961 actttgactc ggccgcgcat attctcaaaa ccggcttcct ccacaatcgg atggccgcgg 2734021 acacctgccg cccatacaac ggtttgcgat ttgatctgct ctggttcttc atcttttttg 2734081 ccgactctga ctccttctgg tgtacattct tgtacagccg ttccgatctt gaactcaact 2734141 ccgttttcct caagataatg tacggcgtaa tcaacaagtt ccggatcaaa gcccggcaaa 2734201 acggtcggcg ctgcttccac acaaatgatg cggacaaggc ttctgtcaac gtcatattcc 2734261 ttacagagct ccggcacgcg agcagccagt tcgccaagaa attcaattcc cgtaaatccg 2734321 gcaccgccaa caacgatcgt taacctgtcc ggccgttttt ccgcttccgt attgtaagtc 2734381 gcaaactgca gctcaatatg ttcccgcagc aggcgcgacg tgttgatgtt ggcaatcgga 2734441 aacgcatatt cttttaagcc tttaatgccg aacgtttcag gcacggcgcc gagcccgatg 2734501 actaaataat cgtactgcaa ttctccattc gcaagcacaa cttttttctc atcaattttg 2734561 attgccttta cggtatcctg tacaaaattc acccgtgact ggttgattac atcttttatc 2734621 tgataacggc agcggtcatg atggagcgta cccgcgctcg cttcatgcat ccatgtcgtt 2734681 tcataatgat aattgtgttt atttacaagc gtaatgtcag catcattcgg cccgacatac 2734741 ttcgtcagcc ttgtcaccgt catcaatccg ccatatcctg cacctaaaat cacgattttg 2734801 ggcttattca atgccatcac atccaccttc tctttttttg cttttgttag acccataata 2734861 aaatcatcat ttgtgttagc ttcagcttat tggcgggatt ttatgaaata tattgaaaag 2734921 ttttttgtga agtccttacc cgtagcacta ttatcatgtt tatccggctg gcccaagaaa 2734981 cattcagaaa aagatcattt catttggtta ttatcgtagc ggcctgcgga aatattttca 2735041 agaacggatg ggcacgttag atccttacga ttttttctgc tgactcgtca atttgaacgg 2735101 caatatggta taattaataa caattttcat ttaggaggca attttcgtat gcgagaggat 2735161 acaaaggttt atgatattac aattataggc gggggaccgg tcggcttatt caccgctttt 2735221 tacggcggga tgagacaggc aagcgtcaaa attatcgaaa gcctgcctca gctcggcgga 2735281 cagcttagcg ccctataccc tgagaagtat atatatgatg tagcgggatt cccgaaaatc 2735341 cgcgcgcaag agcttatcaa taacctaaaa gagcaaatgg cgaaattcga ccaaaccatt 2735401 tgtctggagc aagcggttga atctgttgag aaacaagcgg acggcgtgtt taagcttgta 2735461 acaaatgaag aaacccacta ctctaaaacg gtcatcataa ctgcaggaaa cggcgcattc 2735521 aaaccgagaa agctggaact tgaaaatgcc gagcagtatg aaggcaaaaa cctccattac 2735581 ttcgttgatg atctgcaaaa attcgccggc agacgcgttg cgatccttgg cggtggagat 2735641 tccgcggttg actgggcgct tatgcttgag ccaatcgcaa aagaagtatc gatcattcac 2735701 cgccgcgaca agttccgagc gcacgagcac agtgtggaaa accttcatgc gtcgaaggtt 2735761 aatgtcctga caccattcgt ccctgcggag ctgatcggcg aagacaaaat cgaacagcta 2735821 gtgcttgaag aagtgaaagg cgaccgcaaa gagattttag aaattgatga cttaatcgtc 2735881 aactacggtt tcgtttcatc tcttggaccg atcaaaaact ggggcctgga catcgagaaa 2735941 aattccattg tcgtgaaatc aacaatggaa acaaatatcg aaggcttctt tgcagcaggt 2736001 gacatttgta catacgaagg aaaagtcaac ctgattgcca gcggcttcgg cgaggcaccg 2736061 acagcagtga acaacgccaa ggcttacatg gacccgaaag cccgcgtaca gcctcttcac 2736121 tcaacaagtc tttttgaaaa taaataataa aaaaaggagc ttgtgtctgc gacacagctc 2736181 cttttttatt tgaagatatt tatataattc aatgcagttc ctacaaccag cgcaatcaca 2736241 agggctgcga ctacccagat cattgccata ataatgcggt cctgaatctt ttgggacttc 2736301 ggtgtttttt cttcgttttg ggccatctta ttcgctcctt tcccatgtcc atgccataaa 2736361 gaaagcctgg tgctgaacga ccaagctttg ctgaacgtat atcattcgcg ttttgatccg 2736421 ctctctaaga ccattcgtta aaactatgat acctaaactc accctgcatg acaagcttcg 2736481 gcacttgcac cacacctgcc agcaaatcat aatgtttgac atcctaaata aaacagagta 2736541 cattatataa ggcgaacatt tcatatatta tacttttaaa tattcgtttt taggagtgaa 2736601 aaccatggaa aacgtatttg attacgaaga tattcagcta attcctgcaa aatgcattgt 2736661 gaatagccgt tcagaatgtg atacatccgt acgtttaggc ggacatacat ttaaattgcc 2736721 cgtcgtccct gccaatatgc agacgattat agatgaaaaa ctagcgattt cattagccga 2736781 aaatggctac ttttatgtga tgcaccgatt tgagcctgag acacgaattg attttattaa 2736841 agatatgaac gcacgcgggt tattctcttc tatcagcgtg ggcgtcaaag atgaggagta 2736901 tgaatttgtc cgccagctgg cagaagaaaa tctgactcct gaatacgtga caattgacat 2736961 tgctcacggg cactcaaatg ctgtcattga aatgatccag caccttaaaa aacatttgcc 2737021 ggacagcttt gttattgctg gcaatgtcgg aacgccggaa gcggtcagag agcttgaaaa 2737081 tgcgggagcg gatgccacta aagtcggcat cggaccggga aaagtatgta ttacgaaaat 2737141 caaaacaggc ttcggcacag gcggctggca attagcagcg ctgcgctggt gtgccaaggc 2737201 tgccagcaaa ccgattatcg cggatggcgg catccgcacc catggcgaca tcgcaaaatc 2737261 aatccgattc ggcgcaacga tggtcatgat cggttcacta tttgccggac acgaagaatc 2737321 gccaggccaa acgatcgaaa aagacggaaa gctttacaag gagtacttcg gctcagcctc 2737381 tgaattccaa aaaggcgaaa agaaaaatgt cgaaggcaaa aaaatgcacg tggcgcataa 2737441 aggctcaatc aaggatacac tgattgaaat ggagcaggat cttcaatctt ctatttctta 2737501 tgcaggcgga acaaagctta acgccatccg caatgtggat tatgtgattg tgaagaattc 2737561 catttttaat ggggataaat attaatcata aaaaaacgcc aagtcagcgg ttctccgctt 2737621 gagttggcgt tttctgctac ttcttcagca aagtaagctt atatttgctt tttgagttta 2737681 tcttccatca gttctgccat ttgttttgca tttggatttt cttcattttg caactgttca 2737741 atgacgttca tataatccgt ttcatttcgg ttctggctta atttatatgc cgcttgaatg 2737801 tcttccacct taatcttaaa tccaacaata cctttcaatt cactttctaa gagttttgga 2737861 gaaagcttat cccataacac aggattgtca cgatgttttt cgtatttctc caacatgatt 2737921 gttaattctt ctgctaattc atctttctct aacatacttg cttttccata catgtggaca 2737981 gcctgataat tccacgtcgg aacattttcg cgcgaatacc aggaagaaga aatataagcg 2738041 tgcggtccct gaaacatcac aagcacatct tcacaggctt caaacgttct ccactgagga 2738101 tttccataag cgaaatgccc cgtaatatag taatgatcgt cttttttatt gaatcctaac 2738161 ggcaaatgtg tggcaattgg ttttccttgt tctgttgtga caaccgtacc aaaggagttt 2738221 tcttgtacaa aattccaaat ttcttcagca tttgtgactt taaaatattt tggaatatac 2738281 atcatcatcc acccttcgaa aaatattata tgagtgtttt agccatgatt aaatccgttt 2738341 gttcttcatc acccatataa aatgagtggg cgccggtctg aacaaacccc attttcttat 2738401 aaaaggcaat ggcattttca tttttttccc acacacctag ccaaatgttc tttttattac 2738461 gttccagcgc aatttctatc gctttattca gcagatgttt gccaagccca tgtttttgaa 2738521 agctgttctt tatataaatt ctctcgattt caagtgattc agcacccatt tcttcagact 2738581 gagcatcatc gatattgacc tttacatatc cagcgatttc atgatcaaag taaataaaaa 2738641 agaattgcga agacatatta gataactctt tttccagctg ctcagtgtta aatgcgcttt 2738701 ctaaataggc tttcatattt tcaggtgagt tctgttcttt aaaagtgtca ttgaatgttt 2738761 caatactcaa ttgttgaagt gtttgtaaat cttcccggct gcattttttc atttttacac 2738821 tcattgttcg gattcagccc ctttatttaa aattcaattg tcttgtgtcc cttttatata 2738881 tttaaacacg gaacacatac tgaccttgtt accattccaa aaatcttctt catcaccaac 2738941 tccctatcgt gattttgttg taaatgcaat aaaatatact ccgcattaaa tatatcgtaa 2739001 ctttgctgta tttacaacaa aaatcaaaca acaaagcagc gtttctcttg ccgaagttcc 2739061 cggaactctc tgcatcattt ccccataata aaaacgcctc ccttaacgat gatttatcgc 2739121 taagaaaagc gtcagtaata gttgctatcc gtttttagtg cttagcactc ttcaggcttg 2739181 cctgcattcg ttgctgttct gaacgaagaa ccgcagccgc atgaagcgat ggcgtttgga 2739241 ttgtcgatgg tgaagccgcc gccgagcatg gattgtttat aatcaatcac ggtgccgttc 2739301 atgatgtcaa ggctttcttt gtcaactaga acagtgatgc cgtgctgatc aaacacactg 2739361 tctgattcac tcttttcatg ctcaaagccc atgccgtaag aaagtccgct gcagccgccg 2739421 cctttgacgc ctacacgcag aaacgcgttt tcttcttcat gctctttcat catatctttt 2739481 atatgcaaag ctgctgcttc tgtaattgtt accgggttgc tcatcattat gaacctcctt 2739541 ttaaaaaccg gttgctgtct tttattataa acatgatcgt tccaattctc aaacaaggtg 2739601 ttttacaaga aatagacacc ctcacaaacg gtttcagccg gccctgtcat cattacatgg 2739661 ccgttatctt tccagtttat caccaaatcc ccgcctgcta aatgcaccgt gatgtcttga 2739721 tttcgctttg atacgccgtt taatacagat gcgactgccg ctgcacatgc tcctgtcccg 2739781 catgcctgag taatccctga tccccgttcc cagacgcgga aatgcaattc ttgttcattc 2739841 acggtttcaa cgaattccac attgatgcct tccggaaatc tcggatcttt ctcaatcacc 2739901 ggccccagtg tcgttaaggg tgcctgttca atgtctgcga tcggaaaaac gatatgcgga 2739961 tttcccattg aaacggcagt gcctgttagt tctacttcac caaatgccat cgtttcattg 2740021 attgtgtgct cttccccgcc gtcaagcata ggaagctcgg attttgtcaa gcgcggttcg 2740081 cccatatcga cagtgaccac attcactttt ccgttttcga cttgaacctc cgctttcaca 2740141 agcccggaga gagtttcaat cagaaaagat gtttcctcaa ccagcttatg ctcatatgcg 2740201 tattttgcga cgcagcgcag gccgttgccg cagtttttcc cttcagaccc gtcattatta 2740261 aaaatccgca ttttaacagg cgcttggtct gatgggcata tcaggatcat tccgtcggat 2740321 ccgatccctg tataaacaga agaaacctga attgcaatct ctgacagttt ttcttctgga 2740381 agctgttctt caaattgatt cacataaata taactgtttc ccaggccgtg cattttggta 2740441 aatcgaaatg agttcatagg tgcctccaac tttttttctt tttcttagta taaaagctat 2740501 tataagcgga cacaatacaa ttatcccccg tttttcatac ataaaagctc cttgcactga 2740561 cgcaaggagc ttttatcgtt tatataaaca tgccggcaat ggctgcgctg agcagattgg 2740621 ctaatgttcc tgcaagaaca gccttcaggc cgagacgtgc gatatctgaa cggcggctgg 2740681 gcgctaaacc gccaagcgta ccaagcataa tcgcaattga tgaaaaattg gcgaatccgc 2740741 ataacgcgaa actgataatg gtagcagttt tcttagaaaa ctcgccgatg tgcgaaccga 2740801 agttagaata agcgacaaac tcattcagca ccaatttctg gccgatatag cttcccgcct 2740861 gcaatgcttc atgccaaggc acgccaatca aaaaggcgat aggagaaaac acatagccga 2740921 gaatggattc taatgttacg ccttttaaac cgaacaagcc gaaagccccg ccgagaatac 2740981 cgtttactac agcgattaac gcaacaaacg caagcagcat cgccccaaca tttaacgcaa 2741041 tttgcagtcc tgttgacgct ccctttgcag ctgcgtcaat gacattggct gcgccttcgc 2741101 cttcatccat tttgaaatcg ctttttacgg tttgcgtttt ttccgtttcg ggtataatca 2741161 atttaccaaa gactagtcca gctggagcag ccataaagct ggccgccagc aagtactcaa 2741221 tcggaatacc gagaagcgcg tacccaaaca aggtagatcc cgcaactgcc gatagaccgc 2741281 tcgtcataat cgtaaacaac tcagagcgcg tcagcccggc aatcaggggt ttgatcacta 2741341 acggagattc tgattgtcct acaaaaatat tggcagcagc cgccagagat tccgttttgc 2741401 ttgttccaag gagcttcgac aatccgccgc caatgacacg gaaaacgagc tgcatgattt 2741461 tcaaatgata taaaactgca atcagtgctg agaagaaaat gataacgggc agtacactta 2741521 atgcaaatgc cggactgtct ccgaccttta gaagcggtcc aaaaataaaa ctgatgcctt 2741581 cattcgcata gtcaatcaga agctgtacac ggcttgaaaa ccataaaaaa acagcgcgtc 2741641 ccgcttccca tttcaacacg atgtatccaa acgccacctg tgtgcataaa ccaacgatga 2741701 cggttcttat cttaatattg cttttctttt ctgaaaataa aaacgcgata gcaatgatcg 2741761 caactgcgcc cagcagcccc cacagaacat tcatgaatac tcgtacacct cttaaatttt 2741821 atttaaaaaa atatctttta tacgataaca ataatatttt ttgatgtcta cacatttttt 2741881 tagttctttt gtacggcaaa ataaaaaagg gcctgtccag gcccttttct ttaaaacatt 2741941 ggattttctt caataaaggt atatatattc tcaacaagct cagcaggcgt ttcacccatg 2742001 acgacttctc cgtttaccag agcgaaaagc gattccatac atgtcccgca gtagcttaag 2742061 cagccatatt caaggacatc aaggttggga tccttctcca aaatcgcccg ggcttcctga 2742121 gagccgtgag ccagattgct gacacaaaat tcaatcattg gattcatgcg gtttcacctc 2742181 acatatgtcc attatcgcga atttttcact attcgtcaaa gacaacggat gattcaaaat 2742241 ttattatcgt aacatattat ttctcaaata acgttttact aatttgtgtt ttcaggctaa 2742301 attgtaggtt attttgaaac tattattgtg attttagatc aaattcgata taattctaga 2742361 tgttatttta catagttcgt attttcttca atgtatctat catactcttc ggattaaagg 2742421 ggaattcaaa tgaaaaaatt ggtcttgatc ggcggaggtt acgggaacat gcgcgttctt 2742481 catcgcttat tgccaaacca gctgcctgat gatgtttcaa tcacgttaat tgacagaaat 2742541 ccttatcact gcttgaaaac agaatattat gcccttgccg caggcacaat ttctgaccat 2742601 catatcagag tgtcattccc agagcaccct cgcctggatg tccaatacgg tgatatcaca 2742661 tcaattgata ttgtacaaaa acaagtgctg ttccaagatc gtgaaccgat ttcttacgat 2742721 gacgccataa tcgggctcgg ctgtgaggat aaatatcaca acgtgccggg agcgcctgaa 2742781 ttcacctaca gtattcaaac catcgatcag tcccgcgaaa cctaccaaaa gctgaataat 2742841 ctgagcgcta atgccaccgt cgccattgtc ggagcgggct taagcggcgt tgagcttgca 2742901 agtgaattga gagaaagccg tgatgacctg aacattattt tgttcgaccg cggtaatctc 2742961 attttatcaa gctttcccga gcgtttaagc aaatatgtgc aaaaatggtt cgaagagcac 2743021 ggtgtccgca ttattaacag ggcaaatatc acaaaagtag aagaaggcgt tgtgtataac 2743081 cacgatgatc cgatttctgc agacgccatc gtgtggacag ccggcatcca gccaaacaaa 2743141 gtcgtcagag acttagatgt ggagaaggac gcacaagggc gtattgtatt aacgcctcat 2743201 cataatcttc caggtgatga acatctgtac gttgtcggcg attgcgccag tcttcctcat 2743261 gcaccgagcg cccagctggc agaggctcaa gcagagcaga ttgtccaaat cttgcaaaaa 2743321 cgctggaatg gagaagccct gcctgaatca atgccgcagt ttaagctgaa aggcgtcctc 2743381 ggttcactcg gaaaaaaagc cggcttcggg cttgttgctg accgtccgct gatcggccgt 2743441 gttccgcgta tgctgaaatc cggcttgctg tggatgtata aacaccataa cggttaatga 2743501 tagagaagaa ccgctgatca agtcagcggt tttctgtata cccatgcttc tccatttcct 2743561 cataaacgtc ttttaatttt ggattgcctt caccgacaat tttgtcttct acaagcacaa 2743621 gcggataaaa atactcgtca tttctgattt tttccgcaag ctctttcgca tgttcattgt 2743681 caggcggctc atgaatatcg atgtactgca tctcaaaagg ctgatttgga tattttcttt 2743741 tcagcgcagc ctcaagccac tcgtatgtat ccttggctgt cggcatattt acacagctcg 2743801 cacaaacgtt ttctgccccg tacacgctta gcatgactgg tttcatcact tgtagacgcc 2743861 cccttctcct atgtaagtcc tttcttttaa gtatacagag cctaagggcg tttttataga 2743921 aaaaaaccgt ttttgtgttg aagtctgaat gtgctataat agggaaagca actttgcaaa 2743981 ccaaacaata gatttttatt gttacactga atataatggt tttatgacga cgaaaggagc 2744041 gaatgtcatg actgaagttg aaatgaaaga acaggtgcag gaagtactgg acaaacttcg 2744101 tccgttttta cttcgtgacg gcggtgactg tgagcttgta gacgtagatg aaggtatcgt 2744161 taagcttcgt cttctaggcg catgcggcag ctgcccaagt tcaacaatta cgttgaaagc 2744221 cggaattgag cgcgctcttc ttgaagaagt gccgggtgtc gttgaagtag aacaagtctt 2744281 ttaataaagc agccaggctg atatttgatc agcctggctt ttttattaga gatgttgatc 2744341 aaaccatgag ctgatataat tcaggcgctt gatccgctgt cttgggtgtc cggtgcgtga 2744401 taaattgtgc gatgcattcg gaaaacggac aagcttggtt tccttgccca tttttttcag 2744461 agcgataaac agctgctccg cctgctcgat cgggcatcgg tcatcccgct cgccatgcag 2744521 tatcaaaagc ggtgtctcca cgtttgctgc gtattttaaa ggagaccggt cccagagctt 2744581 ttctgtgtcc tcaaacatgt catgctcaag ctgccagtct gtaaagaaat agccgatatc 2744641 actgacgccg tgaaagctga tccaatttga tatcgagcgc tgggtaacgg cagctttaaa 2744701 gcggttcgtc tgcccgacga tccagttggt cataaaacct ccgtagcttc cgcccgtgac 2744761 accgagccgc ttaggatcaa tatgcggatc tcgtttgata gcctcatcca cagcctgcat 2744821 cacatcgtca taatcctttc ccccataatc tcctctgacc gcattcacaa attcctgccc 2744881 gtagccgtgg cttcctctcg gattgatata aacgaccgcg tatcctttcg ccgccagcac 2744941 ctgaaactca tgaaaatatg tatgtccgta catcatatgc ggaccgccgt gtatgttaag 2745001 aataagtgga tatgttgtct caccttccat ttgtgcaggc ctcatcagcc agccgttcac 2745061 catcacgccg tcttctgtag catattgaat ctcttcaggt attgatatcg tatgctccct 2745121 gacaaacttg tcattcgcgc cagtcagctg tttctcttcc tgtccaagcg ggatactgta 2745181 aagctcactc ggtctgtccg gctttgtcac actggcaata aagtgctgtt catcaggtga 2745241 aagagaaaag ctattgatgt actctttttc cagacgaatc ggatacacaa ggccttcaat 2745301 cgaaatataa tagatgcccg tactgccttg atctgtgccg atgacataaa acccttggct 2745361 gtcctttgtc caaatcgggc gctgttcagc accaccgatc aatgaatctc caatcagcgc 2745421 atccgctaaa tgaacgtcca gcatctcagt aagacatgtg aggcggcctt gttcgatatc 2745481 atagagccac gcctttgaga gcgtagcatt cttatattcc ttttcatttc caagcaaagc 2745541 aagatacctt ccgtctggtg aaaatgagct tgatccgaat gagccgcgat gaggtgtaac 2745601 ctgcttaaga tctccagact ccagtgacat tatgtaaaca tcatgcggct tgctggcatc 2745661 atctgtttca gttaaattag ctgagaaaac aagccatttg ccgtcaggag aaaaagcagg 2745721 atcaccatga tcagctttgt gacttgtcag ctctttcatc tcacccgact ttacgctgac 2745781 aagcacaagc tgggcatacg cacctctcgt cagccctttg ccgtcccgtt tgtaggagag 2745841 gccttgcact tcaacaggtt catagctgtc ctgctctgtt ttttctcggt catcaatgct 2745901 ttccccctct cccaaactga cagtgaccag aatcgattca ccgtccgggg accatagcgg 2745961 ctttgacacg ccatatggga tatcagtcag ttttcttgct tctccgcctt cagtgctcat 2746021 gatataaagc tgtgccgcat cgccttctcg atcagaaata aaggcaagcg tgcgcccgtc 2746081 cggagaccat cttgggtcgg tgcttcgctt ttctccatgt gtccaaggaa cagatcctcc 2746141 cgttttcgtt tcatagatcc atatatttga tgtatacgaa tctttctctt gatttacttg 2746201 tgattttaca tatgcggcac gggtaccgtc tggggcgtat tgaggatcgg tcacagagac 2746261 aatcgctgtg atgtcgtctg cggttatcag ctttttcata ttcatctcct cctttttaca 2746321 tgtatttcgt ttttctaaat aaaaactcct ttatctccag caaaaaaaag cgccctccgc 2746381 tgacgctgag gaacgcttgg catgatctat acacttttta cttgatataa aggatttcgc 2746441 tctattatac ttccctcttt cggaacggtc aaagcgtcta cttcacaatg agggaaatga 2746501 agcgcgagct gttcttttag ctcttctccc tttccttttt cggtcatgac gagaatcgtt 2746561 gggcctgctc cgctgagagc cgttccatat gcgcccttca tctcggcgac gtgctctact 2746621 tttgacagct caggcacaag catcgcccgg tacggctgat ggaacatatc cttcttcatg 2746681 attttcccga caagcggcca atccttggac atgatcgcag caatgaggat attgctgaca 2746741 gcacttgctt ttacggcatc ggcatatgga aactccttcg gaagcacgtc tctcgcgtct 2746801 cttgtcagca cttcataaaa aggaatgaca acgactacgt caatgtcagc attcgggacg 2746861 cggatcattt gggtctcgtc atcctcatgc aggccgatca caagtccgcc gacgagagaa 2746921 gcgccagcat tgtccgggtg tccttcttct agactcgcta aatgcagctt gtccgcttca 2746981 gacagcttta agccgcataa ttcatcagcc agttcaatgg ccgctacaat cgctgcggcg 2747041 ctgctgccaa ggccgcgtgc aagcgggatg tcgctccaca ccttcacatg gacaggaggc 2747101 atttcttttc cgtacaaatc tgcggtccgt ttagccactt ggtagatcag gttatctgta 2747161 cccgccggaa ttccggcgac tgtttctgtt tcagcctcaa aagaccattt gtcgctttca 2747221 aagacggtca gcttcaaata tctgctgagc gccattccga ctgaatcaaa gccggggcct 2747281 aggttagctg tgcttccggg aacagtgaca gagaacagca tgtcggcttc gttcatacac 2747341 gggccgctcc ttttacatat tcaaggatgc tgtcttcatc agtcggcaat gtgacaggct 2747401 tgatttctga aatgtcgacc gctgtgttcg gatctttcag tccgtttcct gttaacacag 2747461 ctacgacctt gctgcctttc ggaatttctc cggatttcac ctgtttcagc actcctgcga 2747521 tagacgcgca agaacctggt tctgcaaaca cgccttctac acgggcgatc agctgatatg 2747581 cgtgaaggat ttcatcatca gtgacttcgt caattttccc attggattcc tcggctgcct 2747641 ttacagcttt gtcccagctt gccgggtttc cgatacgaat ggctgtcgct attgtttccg 2747701 gattttcaat cacttcattg cgcacgattg ccgccgcacc ctcagcttca aagccgcgca 2747761 ttttcggaag gcctgtgccg tttttctcat gatattcctt gaagcccttc cagtacgcag 2747821 tgatgtttcc agcatttccg accgggatcg ctaaaacatc aggcgcttcc cccagctgtt 2747881 cgcacacttc gaaggcagca gttttttggc cttcaatgcg gtaagggttg actgagttga 2747941 caagggcaat cggtgatttc tcacagatgg aacggacaat tttaagcgca tcgtcaaagt 2748001 ttccgtcaat tgcgataatc tcggctccgt acatgacagc ttgagcgagt tttccaaatg 2748061 caatttttcc gttcgggatg atgacaatgc atttcatgtt agcacgggct gcatatgctg 2748121 ccgcagcagc ggaagtgtta cctgttgacg cgcacataat cgtgtcattg ccttcttctt 2748181 ttgcctttgc cacagccata accattccgc gatctttaaa tgatcccgta ggattgacgc 2748241 cttccgtttt gacatgaagc tcaattccga gctgctcaga cagcttcggc aggtgaataa 2748301 gaggtgtgtt tccttcatgt aaagttagcg ccggtgtttg atctgttaca ggtaaaaatt 2748361 ctttatattg atggataagt cctttccaca ttagctccaa ccgttccctt ctacacgata 2748421 tgtgcttttg acttcttgaa cgacttccaa atcatttagg ttttgcagga tatcactgaa 2748481 atcagcttct gatgtatgat gtgtgacaat tacgatttca gctaactcat catggccttt 2748541 aattggcagc tgaaggattt tttcaaagct cacgccccgc tctgagaaca cagatgtaat 2748601 tttcgagaat gaaccaacct catcttttac atgaattctt aaaaactgct gtgcataaat 2748661 gtcagacggc gatttcatgt ttttctcata ttgcggtccg acaaagctgt tgccggttac 2748721 acctaggcgc atatttttca tgacagcgac gaggtcagaa acaacggatg tcgctgtcgg 2748781 catgcttccg gctcccggcc cgtagaacat cgtctcaccg acagcctcgc cgtatacata 2748841 aacagcgtta aactcattat gaacagcaga aagcggatga tggtcaggaa gcagtgtcgg 2748901 ctgtacgctg acctcgattt tgctgccgtc acgctgagca atcccgatca gcttcattgt 2748961 atagccgagg cgtttgctga agctgatgtc ctcgtctgta atttgggaga tcccctttac 2749021 tttgacgtct tccagatcca cgttcatcga gaagccgagg cgcgccaata tcgccatttt 2749081 ccgtgcggcg tcaagccctt ccacgtcaga agtcggatca gcttcggcaa aaccgagatc 2749141 ctgcgcttcc ttgagcactt cctcgtatgg gcttttctct ttgatcattt tggttaagat 2749201 aaagtttgtt gtgccgttca caattcccat catttttgta attcgatctg atgagaggcc 2749261 ttcctctaac gtgcgcagaa tcggaatccc gccggcaaca ctggcttcaa agtagatatc 2749321 gcatccattt tccttcgctt cggcaagcag ctcggagccg tacacagcca ttaagtcctt 2749381 gtttgctgtg acaacatgct ttttcgatct cagcgcgtcg accaaatatt gttttgtctg 2749441 ttcaacgccg ccgatcacct cgatgacgac atcaacatct ggatcatcaa tgacatcata 2749501 cacttctgtc gtgagcactt ccttcggcaa atctacttct ctctttttct ctaaatcttt 2749561 tacaagcact ttttttatcg taaccggaca gccgacctga tgcataagct tatcctgatg 2749621 gtcttgaata attttaacga caccgcttcc gacggtacct aaacctaaaa gccctacacg 2749681 aatcgctttc aaaaaaactc cacctttctt ttgattgtcc tcttggaaaa gacaattgtt 2749741 aactcaacac agacatataa gttacaaaca ttatataagc ccgctcctgt tttgacaaga 2749801 catcattagg ctgaattttg cgaatgtaaa cgcttaacgc attgatatga caagattctt 2749861 tattttctaa ttatttttgt cagattttct cctcaccttg agctgccttt gccgagccag 2749921 ctgacgcgtg gaacaaacag cttctgcgcc cgcatattca tgaattcctg cgctgtattg 2749981 agaaattgtt cataacgccc acagtcatta agaatgaagt caagctgttc ttcaaaataa 2750041 tgcttttctg attctgatga catgtaatag ctttctacga tttcaaaata atgaagcggg 2750101 aaaagcagac ggctgtataa aaggcgtttc gaaaatgaag acagcggtgt gacttgctcg 2750161 tattcctgta aaaagagaaa gccctgctga ttaaaatctt gtctgtgatg caaaaacgta 2750221 tgcctcatat attcagccaa atcacgggaa gcgtggtcaa acacccaatc cgccggaatc 2750281 ctgatcaatg attccggtga ccatgtatgc ctttccatcc gctgatggca tatcgttcct 2750341 gaatcagcgg cttggggctt gtcatccagc tcagtgtcca ctaaatattg tatcgcgttt 2750401 tctgacagtc ctaaataata tggaaatgat tcgatcattt ttttatcgaa tggctcatgc 2750461 ggaggggtct gaacctttct ctgccaaaat gcttccagct gatcaattcg ttttccccac 2750521 agatccttcc actggccgat tcttccggcc gccttcacct catatggata tcctcggcct 2750581 tttcggtgaa attccgcaag ctccgctcca atggagaacg ccctgtttga ataagggggg 2750641 gccgccttca gcagagcgta cgtttttccc tcatgttcaa atgtcagttc accttctttt 2750701 gtaaagataa aaaccgaaac gtatgggtca ctttgttctt gtaaatactg actcatgtaa 2750761 taaagctccg ccagctctgt ttctgagaat tgggaaacgg ggacaatcag aaagtatgaa 2750821 ttaggcgtct gaaagcattg atatgtgtgc tggtacatgg aaagctgcct gatgtgaatg 2750881 ccgtattttt cttttattgt acctttcacc atgatcacct gcctgttgaa ttagggctca 2750941 tcacatcgta gtcatacaca gccggaatta tgaatacata ttttaatccg aagaaggcgc 2751001 aagaaaaagt cgtaaacttc tcaagcattt tgtataaact agtaaaaaag attgggtgaa 2751061 gctgatgtca gaaaacgaac aattcagtca gatggaagct aaagcaagag cacggatgaa 2751121 ggagcgcggc gttgaggtat cagacattgc cgagcttgtc ttttttctgc agaaaaaata 2751181 tcatccggat ttaaccattg atgaatgcac gctgaacgtc aatcgtgttc tcgcaaaacg 2751241 cgaggtgcaa aacgcgattt taacgggcat tgaattggat gttcttgctg agcagaaaaa 2751301 attgtctgaa ccgctgcaaa cgatgctgga aatagatgaa agcctatatg gagtagatga 2751361 agttctggca ttttccattg tgaacattta cggatcgatc gggtttacga actacggtta 2751421 catcgacaaa gaaaaacccg gaatccttaa acgattgaat gataaatcaa ccggtgaatg 2751481 ccataccttt ttagatgaca tcgtcggagc gatttccgcc gcggcttcaa gcagacttgc 2751541 tcaccgcgcg cggcatacag aataagggca cccttttagg gcgccctttt ttcaaatgta 2751601 tggaatccat tcagtcagag agtcaatggc gtgagtcggt ttttccatat cgtctgtcat 2751661 atgttctctt ttcgttacgc ctgtgtgaac gagcagcgta tccatacccg cgttaatgcc 2751721 ggccataata tcagtggcgt agttgtcgcc gaccatgagt gtttcagaca catctgtgcc 2751781 gagaacgcgc atcgcctgct ccataataat tgattccggc ttgccgataa atacaggctg 2751841 tacacctgta gatacggtta acaccgatgt cagtgagccg tttcccggca ggagccctct 2751901 ttcagtcgga atcgcaatat ctccgttagt ggaaataaag cgggcgccat ttctgattgc 2751961 caggcagcca acagcaaatt tttcgtatgt aatggaacgg tcgatgccaa caacgacaaa 2752021 atccgcgttt tctccgccaa atgtcaggcc gttttcttca atcgcctggc ggattccttc 2752081 ctccccaatc acatacacag acgcgtcttt tttctgctgt gcaatgtgct gggcagttgc 2752141 catgctggtc gtgaagacct gctcttctgt tgccggaata tcaaaagaca cgagcttgtc 2752201 cgctacctgc ttcggtgtgc gcgaagagtt gtttgtcacg aaaagataag gaacgccgcg 2752261 atctttcagc gttctgacaa attcacacgc ctcctcgatt ttttccgtgc cattgtacat 2752321 cgttccgtct aaatcaatta aatacccttt atatgttttc atatccaaca ctcctgtggc 2752381 tttccagttg ttatttaaac gcggaaacag gtcctagctc tgtttccaaa tagcttctga 2752441 tccgtttcgg gaagtcctga agagctgttt gatgcgcctt gatcagcctg taaagctcgc 2752501 cgctgtcagc gagcagatac tgttgaacca acgttttgcg gtaggcgatc aattttttga 2752561 gctcatcacc ctctttttcc gtgacaactt tctcatcaac aagtatatcc ataatgtcgt 2752621 catagctgcc cgggtcccgc ataataaagc cgtcaatcat gtcattgcct gtatccaaaa 2752681 tgcattcgat taacagatgg cctatacgct gaagtgccaa ttccccgatt tcagactgcc 2752741 agtctgtttg tgagtcaaat agcgccagct ggtgctcgaa gaaccctagt gttttttcga 2752801 ttttgcttct gtcaacaaaa tacatgacag catccccttt gtgtatattt attttctgat 2752861 ccgtttcaag acaaaatacg cacagccgaa attgcagtat tcgtaaatat attcatctaa 2752921 tgtgctgatt ttcgtttcga aggttgcctt ttgattctgg tcgtcaaaga agcccttgag 2752981 ccttaactga ccgtatcccc agtctcccac aatataatcg tatttattta atatatcgga 2753041 gtagcgggct ttaaaagcct cttcgttgaa gccgtctttg aaattgtgca ccaattcaaa 2753101 ttcggcattt tgaataagaa tcatgatctc acctcttttt tcactcattc ctatcataat 2753161 tcattgcccc gtccccatca attgctaaag aataaatcat gcgatttggc taccctacac 2753221 atgaggaggg attgataaat gaaacgaacc gctgtcagcc tctgcctgct gaccggacta 2753281 ttatccgggt gcggaggcgc aggattggat aatgcccaaa atgtccggaa tcagacgcag 2753341 aatcaaacca aacccattca tgtgtcggac cgcaacgagg cttttaacag gcataatgag 2753401 aacgaacaat ttggctatgt ccgctatcaa aaagaacaat ttgacggaga acagcagaaa 2753461 acgccggtga tgaaccggga agaaaccgct cacatgatat caagtttaac ggttcagctc 2753521 ccccatattc aagatgctgc gacattggtg actgaccgag aagcgcttgt cgtatacaaa 2753581 accgattcta aaaaccggga gctgaccgcc gatcaggtga aaaaaacagc ggcttctgtg 2753641 ataccgcgat actatcacgt gtatatttcc gataatccaa accatatgca atccgtcgaa 2753701 aattacagca atctcggctc tggttcaagg gatattagag agatcatgtc ggggacgatt 2753761 caagaaatga aaacctcccc gcaaggaagc cctgtctcag agaatgaaaa tgccaatgga 2753821 gaaacgcgtc aggacatgaa aatcgatagg aatgacaaaa acgccagatg atctggcgtt 2753881 ttggcattat gcttgtgctt gacgcttttt agatgcttcg tttacttgtt catccgcatg 2753941 gtaagaggaa cggacaagcg gaccggcttc acaatggctg aagccttttt gcatcgcgat 2754001 ttcttttaat tctgcaaatt catcaggatg gtagtatttt tggactttca agtgtttctt 2754061 cgtcggctgc agatattggc cgattgccat aatatccacg ttgttcgcca agaggtcgtc 2754121 cattacttca ataatctctt cttttgtttc gccgagtccg atcatgatac ttgattttgt 2754181 cggaatgtca ggctgcattt ccttcgcacg gcgcaaaaat tccaatgaac ggtcgtacgt 2754241 cgcacgcgcg cggactcttg gcgtcaggcg gcgaaccgtt tcgatattgt gattcaggat 2754301 gtctgggcgt gtatccatca aggtttttag gttatcgtag tttccgccca tatcagacgg 2754361 cagcacctca attgttgtga acgggctttt tctgcggatc gcacggacag tttccgcgaa 2754421 aatgcctgcc ccgccatctt tctgatcgtc acgcgcaaca gccgtaatga ccgcgtgttt 2754481 caaattcata agcgcgactg aatccgctac gcgttccggc tcttgcagat caagctcagt 2754541 tggaaggcct gttttgacag cacagaaacg gcatgctctt gtacaaacag aacctaaaat 2754601 cataaatgtc gctgtacgtc tgaccgccca gcattcatga atattcggac actttgcttc 2754661 ttcgcatacg gtatgcaggt tgttttcccg catgagtttt ttgagccctg tatagttttc 2754721 atttgtattt aatttaattt taagccattc gggctttctg aggtgttcgt ctttctttgc 2754781 caattcccat catctccaat atccaatata ctcaatttct gacacgaaac attctgaaaa 2754841 cgagaaaggt gcaggtttta gttctgcaac aaaaataatg tttttctaac taaagaaagt 2754901 cttttcttta gacactttaa cataggaaaa atttctcgac aagggaagat gattactgac 2754961 atttttaagc cgggttgccg caaactatgt gtattcaata tgaaaggaga ttattttgtg 2755021 aaagttttgt tatccgctct tcttctcctt ttgtttgcat ttgagccttc tgcgtctgga 2755081 aaaaaacttt cagatccagt gctgtcgaaa cggatggaat tatatcataa aatcgaagct 2755141 gtgacgcaga tcccttggta tgcgctcgcc gctgttgatc aatacgaaga aaacgtgcgg 2755201 agcaaccgga aagatctgcc tgaaaaggcg ggaatcatca gcatctatat acccgatgat 2755261 atctggagcg ggcctgaaaa cccgaatccg aaagacgatg cgccgttaag cattaaagtg 2755321 tttgacggaa tcggaatgga tggcgatgga gacgggaaag ccgaggtcag caacgatgaa 2755381 gatatcttgt atacgttcag ccaatactta ctgtcgtatg gcacagatga agacaacatc 2755441 cggatcgggc tttggaatta ttaccggcgt gatcagacag tggggattat atctgaattc 2755501 atgaagctgt ttaaagccta cggccatatt gatctgggcg agcatgcatt cccgcttccg 2755561 atcagaaccg attacagcta ccgaagcacg tggggagatg cccgcggctt cggtggaagg 2755621 cggattcatg aaggtacgga tatctttgcc cattacggcc ttcctgtcaa atccacatgt 2755681 tacggcgtag ttgaaatgaa gggctggaac cgcttcggag gatggagaat cggcatcagg 2755741 gacattaaca atacgtatca ttattttgcc catctcaatg ggtttgccaa agggattaaa 2755801 acaggacaaa tcgttgagcc tggccaagtg atcggatcag tcggcagctc cggatacggc 2755861 ccgccgggaa ccgccgggaa gttcccgccg catctgcact atggcatgta caaagataac 2755921 ggaagaaccg aatggtcatt tgatccatac ccgcatttga gggcgtggga gcgatatgaa 2755981 taccaaaaaa agaagtaaca aaaagccgcc tcttcaacag gcggcttatt tgctgctttt 2756041 ttcttttttt gaatcggcac cgttttcttt gctgctcgga agctggacag aaggcgtgac 2756101 acccgagccg ccgcttccat tataaaactg cggcacttcg ccctgcactg ctttaatcga 2756161 tacaggaaca ttatttgtga cgacagcggt tttgctggca aatggaatga tgaccttcac 2756221 tttaatttcg acaaagatgc tgatatcaat aagtgcgtta tttatgccat acggcttgat 2756281 tttggttttg acatctgtaa aagcgtcacc gattaaattg aaccggaccg ggattttcgg 2756341 cccgaggttt ccaagaaggc tgttgccggt tacctgtccc agcggaatgt tgatcataat 2756401 gttttcactg gcgccgctgt gtccggtatg ggtttccatc tctttcaaat gagcctgaag 2756461 ctgctttgtc acttttgttt tcacactgtt tacaacctgt gtattaaaat cgattgtcgt 2756521 taagtttccg ttttcatcag aattcatttg aaacatatct ttcatatttt cactgtcaga 2756581 catatagtcc tcaatcgaat cctggatcac ctctgtcgct atacgcttcg tttccatctc 2756641 gccgatgtcc attaaaacag gtttgatcga gccattgatc atccaaaggc tgaccgttgt 2756701 tgacaggata aaaaagacaa cggacaggag catcacgtaa cggaaaggca aaggtcctct 2756761 cttgcgaaaa gggccgcgat atcttggcaa gaaaatcccc ccttacatat cacaatgtat 2756821 gcttgtaaga ggggacatag taatagccgg ggccaattta ttttatttca tcatttttaa 2756881 aagcgcttct ctgccgctca tgccgacttt gatgccaaga tcttccgcag cgtacgtgac 2756941 ggattctaaa ggtgcgtcta acagctggtc aatggtgcgg acaccaactg cgcgtcccgc 2757001 cacgatgccg cgctccttta atttttcatt cagcagcgcc acatcaagcg cgccgcacat 2757061 aatgtatccg tgatcattgg cgacggccat aaaattcgtt ttgggaagct ttactgtcac 2757121 agctgtaaaa ggctgtcctt ctatcatgat cggtgtcagg tttaccacgt caaccactcc 2757181 cttcattcat cactttatga tgaagggcac agcttgttgt gggctgactg ccttattgtg 2757241 caagcttcca agcaagcaga tcccgcaaaa attccggcat aaaatattct ttttctgcag 2757301 cgtcgcgaat caacggaaac agtttgccga gcgtaaacat atcaagcacc gcaacggagt 2757361 attgtttatg tttttcaata tcttccccgt tcagtgtgat ccgagtgacg tgggtgatcc 2757421 cgtcatcgag ccgtttcgtt tctacctcaa cgccggcata caccattttc cccatcactt 2757481 ctccgcggaa gccgagtcct ttgatccgga gctgctccat ttgttcggaa gcggcatgga 2757541 caatggtttc cttcagttct tctcccgtca ggcggacagc caccgggttg atcggatgcg 2757601 gacagatgcg gtgcagatcc agctttgtca caggacctgc ttttagcgga ccgagaatga 2757661 cacctgaatt gaccatactg atgtccgtct cgcaccattc ctttaaggcg tatgccaaaa 2757721 gcaaaggcag ctctgattct tcaaaccact tcacctcagc atcttgtgca agctctgcaa 2757781 cggcatcgga cagtttctcc tcggcttcac gttctttttc attgagaaac gctttagttt 2757841 ctgcggattc tcctgtccat tccgccatgt tctgcacaga agccgttttg ctgttgatgc 2757901 ttcgctgtac gctgtccacc gtgatttcta cacagccgac ataatgcccg tatttctcgg 2757961 cgctggccag cagtacccca ttaaccactt gtccatcttc gagcaaatga tgggtatgtg 2758021 attcgaggat tacatcaatc tcaggcaccg cttcagccac tgcttgatca tcaagaatgc 2758081 ctaaatgtga cagcagaacg ataatatcag cctgcccttt cacttccaga atggtttcct 2758141 ttatgctttc aagggcatcc gtaactgtcc atcccagctt gtcatataca ggataatacg 2758201 gcacagttac acctaagaaa gcaatggaca taccgttttt caatgatttg atatggtaag 2758261 gcaccgccca ggacggacgg tttccatttt tatcaaacag gttagagacg atgacaggaa 2758321 attcagcatg atcatataag gcagcaagct cttcatgcgg aagcgtaatc ccttcgttat 2758381 tgccgatcgc cgctccatca atgtgaaggc ggtttaagag atcgacattc gcttttccga 2758441 atgtcgcctc tgtcacgaat tgaaaacgat caagatgatc gccaatatca aaaacgagcg 2758501 tctcttcgcc gtctgactga tgctcttttc ttttctgctc gatataatct acaattttcg 2758561 gccagttttc aaaatggctg tgcaaatcat ttgtatgata taagcggagc ttctccttca 2758621 taatatctct ccctaatcgt tcagctgaaa atgccttcat aaatgagctg gcagccgatc 2758681 aaaatcaata cgatccgcat gatcataacg atcgttttcg tctgcatttt tctgttgatg 2758741 gcggcgccaa gctttccgcc gaaccaagcg ccgggcacaa gcgcgagggc gtacagccaa 2758801 ttgacgtgcc cggaaatcat atgtgaaaca gaccctgtca tagaagacag gaaaataata 2758861 aacatggacg ttgccaccgc aaccttcggc ggaaacagaa ataacagcat catcgccgga 2758921 accatcagtg atccgccgcc tataccgaaa agtccgccta aaaaaccgac aacaaaggca 2758981 atggcaatac cgacagaggc ctgatatgag tacgtataag gctcaccggc atcatcctga 2759041 aatgtccgga taattccttt gtgcgctttg ttgattggcc gggctttcgc tttcagcatt 2759101 aaggataatg aaatcagaat cataaaaatg ccaaaccaaa cggaaaacga gtttgaattg 2759161 aacagctttg acacgtaagc cccgatcatg ctgccgggac ccgaaccgat aaagaaaatg 2759221 agtccgctct tataatcaac tgttttatat ttaatataag ccaaagttga agaaaggccc 2759281 gtaaaaataa tgaccaaaag cgaagttcca atcgcaacct gcggcgtcac atcctgaaac 2759341 agctgcgtca ctgtgcttaa aaacatcaga gatggcacaa tgacaattcc gccgccaagc 2759401 ccgatcagac ttcctaccgt acctgcgatt aatcccagta cgaccaaaat cacaaacgac 2759461 atcaatcaaa acctcttttc taaaataaat cgagctgtct cggagcaagt ccgctgtact 2759521 cgatatcaag cagttcaagc atctgcttgc cattatccgc agcgtcaccg ccggaattgt 2759581 tgttgaacag gacaaaaaca tccttacatt gctgctgcaa ttcattcagg tgctttttcc 2759641 aatcctccag ctcctgttgg ttgtagcggt ataagtacct gacctcccgc cagtttttcc 2759701 cgccatcagg cttcatccag ccctgcttgt tgcgtccgtg aaacctgacg agcgttttgt 2759761 tttcatcggt cgcgcgcaac acggtcggaa cgctgccttc tccgatttgc ggttcatcac 2759821 agacactgtg aatccagcct tccgctttca taaatgaaag cgtctgctca taaaatggcg 2759881 gcgagaacca ggaacggttt ctgaattcaa gcgcgcaagg aatatctccc atttggtgct 2759941 tacaccatct caaataggcg acattctcct tcttgcagtc aaaccacggc ggaaattgaa 2760001 acagcaccat ggcgagctta ttgctatgta aatatggcgt taaagacacc ttaaacgcat 2760061 caaacatctc ctcttttgag tcaaagggaa tttcgccgcg ctgatgccct gtcatgccct 2760121 gatatgcttt cacgataaat tggaaggttt cgggcgtttc cttcacccac ttttcattat 2760181 tgcgcgccgg ctgaatcgcg taaaagctcg cgtctaattc cacgatcgga aaatgggagg 2760241 aataggcctg caattttttc tggctggccg ttttcggcgg atagatgctg tcatgatccc 2760301 cccatcccgt cagtccgata taaatcacac tcattcacct ctcttccagt ttatcacacg 2760361 tgttttcagg tttcctcgga aatgctgttc atatggcggg aaaatgcctc acgcaaatgc 2760421 tgatattgtt cctcattcgt atctaaaaac gcctcttctc ttgaggaagg aatgtgctga 2760481 tattcaatag gcgcctgaaa ctgctcactc gtaaaatcgt acaccacacc attgatgctg 2760541 ttataaaaat gccagctctc atcgactctt gttttgaaaa tcgtgccgcc gaaatggtct 2760601 tgaatcacca atgccgtcac gccgcattgg ccgcatgacg ggcattcttc cgtccattta 2760661 gagctcgaat ggcgcgacca ggattgctta agtatgtatt tgacatgctc cattgcctcc 2760721 gcctccttta aaaaaagata ccacgttgat gagattttaa aaactagaac ggaggaaatc 2760781 aaaaaacccg gcggtaaaat ccgccgggct tacgaaggaa cgaccagagc tccgtcaatt 2760841 tcagtgactt tttccccatc attgtacacg caccggcctt tgctgtaagt ggccgaaatg 2760901 ctgcagggaa atgtatgtcc ttcgtaaatg ctttttttat gctttgcaaa catcgattct 2760961 cttgtaacag tgtacggctc catgctgacg agcacgaaat ctgcatcaca ccccgcctca 2761021 agccgccctt ttttctgaag gccgaatcgt tttgcagggg ccgccgctgt ccattctgcg 2761081 atggtttcaa atggaatctg atgctcaagc gccagttcca gcattcctaa taaagtgaac 2761141 tgcccgccgc tgattccgcc ccatgataaa aacatgttat cctcccgctt caaggatgga 2761201 cggcaagggg aatggtctga ggaaaccatg tcaatgtccc cggcaatgag cgtctcgatc 2761261 agcgtctctt ttgattgccg tgaccggagc ggaggcgcgc attttgcgac agagcccctt 2761321 tgccgtaaat cgtcatggct gaacaagaca taatgcggac atgtttcaac cgaaacatca 2761381 agaccttcct gtttcgcctc tctgatcagc cggaccgctt tcgccgtgct gatatggaca 2761441 aaatgaaccg gacagcctgt caccttcgca tactgaatcg tgcgatacac cgcttcaact 2761501 tctgcttcct ccgggcggga ggcggcgtac gcatccgcat ccacctttcc tttattggcc 2761561 aaaaccatct gcaagtagct tgtgatcgcg tcgctttccg cgtggagagc gaggattttt 2761621 cctgcagccg cgatttctgc catgcctttg agcaatgtcc gttcatcaac agagcggaac 2761681 tcatcagtgc ctgactttga taaaaacgct ttaaacccga tcgctcccgc ttcagccatc 2761741 ggacggatgt cctcgatatg gcctggcaca aggccgcccc atagcgcaaa atccacggca 2761801 gatttttgcc tgcctagctc agcttttgcg agaagatgct ctgccgtcac ggttgatgga 2761861 atacagttga gcggcatatc aaaataggta gtgcaaccgc ctgcggccat catttgagaa 2761921 cctgtttcaa acccctccca atcctccctg cccggttcat taaaatgaac atggcaatct 2761981 atcacaccag gaaacacgta tttcccgtct gcctggatga tttccgtccc gcttgcttca 2762041 atgtcagaac ctatctcggc aatgacaccg ttttgaacta caatatcagc ttctataacg 2762101 ccatctggcg taactgcctt cgcacctttt atcaccatat cgtaagccat attgatcccc 2762161 ccatgtcagg atgacgattt tccatgtcag tttatgtaac acaaccagtt ctattttcaa 2762221 cagtttactg ctactatgat cgtattacat cagcaaaacc gctagaattc ctattgaaaa 2762281 ttattcacct taaccaatgt ttttatagaa aaggagaatg cgctatgaat attcttgatg 2762341 tgatgaaaat accggctttt gaaaacgcca atttaatcgc tggaaaagca ggaggggaaa 2762401 gagaggttca gcatgtcaat atgatggacg ctccggatat cgtagacttt ttgcataaga 2762461 atgaattgct cgtcaccacc gcctatcacc tgaaggatca cccgcatcaa ttatctgaac 2762521 tgattcggca aatggcaaaa cgcggctgcg cgggcctcgg cattaaaaca aagcgctatc 2762581 tggaagatat cccgaaggaa atcatcgaac tggccgattc atatgcgttt ccgatcattg 2762641 agcttccgga acacatccga ctcggcgata ttgtgaatgc cacactcagc catattctcg 2762701 atatgcgttc taacgagctg cagcaagcca tttacgcgca caaaaaattc acaaaccaca 2762761 ttatgagcgg caaggggctg caatccctcc tcaaaaaggt gtcagacatc cttcagcttc 2762821 ccgtgctgct gcttgaccag catgccaaaa tgctgtctgc gtctcatcag atttcagttg 2762881 agaccgaaaa gctgaaaggc accctgaata ccgtatccgg gccatttttc acttgtttct 2762941 ctacaatctc agatcagaaa acatattctg tcctgcctat ttataatcac gaaaaaaact 2763001 gcggctacct gctgataccc gacatggtgc aggcaggcga caaaggattg atcctcacga 2763061 ttgaacaagc ggccaacgtc atttcctttg aactgctgaa ggaaaatgcg ctgaagcagt 2763121 tcagccggcg ggcccgcaat gagtttttca acaattttat tgagcggacc ttttcttcag 2763181 atgacgaaat caaaaaccgg gcgaaagaat tcaagctgcg ctgggatcaa aaatacatgt 2763241 gcatcgccgg caaactcgat cgcaatgacg aatcaatcag ctttacagaa aatcagctcg 2763301 cttccgacag cgtattcgaa tttcttgaag gtgaattatc agccttcccg tttccacctc 2763361 acttctttat gaaaggaaat gtcggcatta ttctaatcga ggcgacagac agctggagtg 2763421 aaatgcacgc ctcggtgatc agctttttag aacagtttca aacacaggtc agcgctcaat 2763481 ttaaacgaac cgtgtccttt ggcatcagca atatctgcca aaagctcatt gatgttcccg 2763541 acgctttcac agaagcttct gatgctctgc aatcggggca tttgtcaaga agcaccgcat 2763601 ttatccaggt gtatcacgcc aaagatgtgc ctgagcttct gcgcttgctc ccagttgagg 2763661 atttgaagaa attttacaac tccacgcttc agagcctcgc tgaaaaacag caggaggatc 2763721 aaagcctgct tcatacgctt tccgtctatt tagagacaca ctgccaaatt tcagagacgg 2763781 caaagcgtct gtacgttcat cgcaatacgg tcatataccg ccttgaaaaa tgcgaagagc 2763841 ttctggggaa aagcttaaaa gatcctgaaa caacgatgcg tttgcggctt gcattacgta 2763901 tgcagcggct gatcagctaa agtttgttac attttcttac aaaacgaatc gtttttcgtc 2763961 actttcagca atcacacctg tctttttcag ctactgtatc caatgacacc cctcgaccgg 2764021 aacgatatta tgttactaaa gttcacatac agggagggac tatagtgaaa aaaagatcgt 2764081 ttaaggtgtt tacacttagc ctgcagcatg tgctcgccat gtatgcaggt gcgattttgg 2764141 tgcccctgct tgtcggcagg gcgctgaatg taacaactga acagctgtcc tacctattgg 2764201 cgattgacct gttaacatgc ggcgtcgcta cgcttttgca aaccttgcgc ggaacataca 2764261 tcggcatcgg gcttcccgtc atgcttggca gttcatttgt ggccgtcacc ccaatgattg 2764321 caatcggcag caattacggc attcacgcga tttatggttc catcattgcg gccggtgtgt 2764381 tcatcttttt gtttgcgcgt tttttcggca agctgactgt gttatttcct cctgtcgtaa 2764441 caggtaccgt tgtgaccttg atcggccttt cacttgttcc gacaggtgtg aaaaatatgg 2764501 ctggcggcga aaaaataaac ggcagcgcca accccgaata cggttcgctc gaaaaccttc 2764561 ttctctctgt cggtgtcctt gttctgatct tagtcctcaa ccgctttctc aaaggatttg 2764621 cccgaacact gtccgttctg atcggcatcg ccgccggaac agcggcagca gcgatcatgg 2764681 gcaaagtcag cttttcttct gttacagaag caccgttctt ccaaatcccg aagccttttt 2764741 acttcggagc ccctgcgttt gaaatcggtc cgatcttaac gatgctgatc gtcggaatcg 2764801 tcattattgt ggaatcaacc ggcgtttttt acgcaatcgg aaagatatgc ggcagacctt 2764861 taactgacaa agatctcgtc aaaggctatc gagcggaagg aatcgccatt ctcatcggcg 2764921 ggctgttcaa tgcctttcct tataatacct ttgcgcaaaa cgccggctta ttgcagctga 2764981 ccaaagtgaa aacaagaaac atcgtcgtta ccgcaggctg tatccttgtc tgtctcggac 2765041 tgattccgaa gattgccgcc cttgcatctg ccgttcctgc tgctgtactt ggcggcgcga 2765101 ccgtcgtcat gttcggcatg gtgattgcct ccggcgtcaa aatgctcagc acagcggatc 2765161 tcaaaaatca ataccacctc ctgaccatcg catgctcaat cgcactcggc atcggcgcca 2765221 gcacggcccc cgggattttt gctgaattcc ccgctccgat ccggattctg gtcagtgacg 2765281 gcaccatcac cggaagccta accgccatct ttttgaatct atttttcagc ttgcgcgaca 2765341 aaaaagaatt aacagcacag caaacagaac ttccggtatt agaacataca ctcgcattag 2765401 aaaaagaggt gtaaaaaaga tgaaggaaca gcacaatgcc ttacagctaa tgatgctggg 2765461 gcttcagcac atgcttgcca tgtatgcggg agccattctc gttccgttga tcgtcggagc 2765521 agcgatcggg ctgaatgcgg ggcagctgac gtatttaatc gcgattgatt tgtttatgtg 2765581 cggggcggca actcttttgc agctctggag aaaccgatat ttcggcatcg gccttcccgt 2765641 tgtgctcgga tgcacgttta ccgcagtcgg cccgatgatt tccatcggaa gcacttacgg 2765701 tgtcccagcg atatatggtg ccattatcgc cgcaggactg attgtcgtct tagccgcggg 2765761 cttcttcggg aagcttgtcc gtttttttcc gcctgtcgta accggatcag tcgtcatgat 2765821 catcggcatc agcctgattc caacggcaat gaataacctg gccggaggtg aaggaagcaa 2765881 agaattcggc tcactcgaca acgtgctcct cgggtttggc gtcacagctt ttatcttatt 2765941 gctgttttat ttctttaaag gctttatccg ctccatagcg attttactcg gtcttatcgc 2766001 aggaacagcg gctgcatatt tcatgggaaa ggtcgatttt tctgaggttt tggaggcgtc 2766061 ttggcttcat gttccgtctc tgttttattt cggaccgcca acctttgagc tgccggctgt 2766121 tgtcacgatg cttctcgttg caattgtcag cctcgttgaa tcgacaggcg tttattttgc 2766181 cctcgctgat atcacaaacc gcaggctgtc ggagaaggat ctggaaaaag gctaccgggc 2766241 agaaggcctt gcgattttgc tgggcggctt atttaacgcg tttccctata cagctttctc 2766301 gcagaatgtc ggcatcgttc agctctcaaa gatgaaaagt gtcaacgtca tcgccatcac 2766361 aggaatcata ctggtcgcga tcgggctggt tccaaaagca gcggccctga caacagtgat 2766421 ccccacccca gttctcggcg gcgcaatgat cgtcatgttc ggcatggtca tttcttacgg 2766481 gatcaaaatg ctatccagcg ttgaccttga ttcgcaaggc aacctgctga ttatcgcctc 2766541 ttccgtcagc ttggggcttg gcgctacaac agttcccgcg ttgttttcat ctctttcggg 2766601 cgcggcctct gtcttggcag gaagcggaat tgtgatcggc agtttgacgg ccattgcact 2766661 gcacgctttt tttcaaacca aacagccgaa tagcgcagac ataaaaacgt aaaggaagat 2766721 gccaatgttc acaatggatg acctgaacca aatggacaca caaacactga cagacacact 2766781 tggctctatt tttgaacact cttcatggat tgcggagaga tccgcagcac tacggccgtt 2766841 ttcgtccctt tctgatcttc accgcaaaat gactggcatt gtaaaagctg cggatcgcga 2766901 gacacagctt gatttaatca aaaagcatcc ccggctcgga acaaagaaaa caatgagcga 2766961 tgactcggta cgagagcagc agaacgcagg gctcggcaaa ttagaacagc aggaatacga 2767021 ggagtttctc atgctgaatg aacactatta tgatcgcttc ggctttcctt ttattttagc 2767081 ggtgaaggga aagacgaaac aggacattca ccaagccctg ctggcaaggc ttgagagcga 2767141 acgagaaacg gagttccagc aggcccttat agaaatttac cgaatcgccc gctttcgtct 2767201 ggctgacatc atcactgaaa aaggagagac gcaaatgaaa agaaccatgt cttatggcaa 2767261 aggaaatgta tttgcatacc gaacgtattt aaaaccgctc actggagtga agcaaatccc 2767321 ggaatcatct tttgccggaa gagataatac cgttgtcggc gttgatgtga catgcgaaat 2767381 tggcggagaa gccttcctgc catcatttac agacggagac aacactctcg tcgtggcaac 2767441 ggattcaatg aaaaacttta tccagcgcca tctcgcatcc tatgaaggaa cgacaaccga 2767501 ggggttccta cactatgtag ctcaccgatt tttagatacc tattctcata tggacacgat 2767561 cactctgact ggcgaagaca ttccgtttga agcaatgcct gcatacgagg agaaagagct 2767621 cagcacaagc cgcctcgtct tcagaagatc gcgtaatgaa cgaagccgct ctgtgctgaa 2767681 agcagaacga agcgggaata ccataacgat tacagagcaa tacagcgaaa tcatggatct 2767741 tcagctcgtc aaggtgagcg gcaactcctt cgtcggcttc atccgggacg aatatacgac 2767801 tctcccggaa gacggcaacc gcccgctgtt tgtctattta aacatcagct ggcaatatga 2767861 aaatacaaat gactcatacg cttctgatcc agcacgctac gttgcggctg aacaagtccg 2767921 cgacttagcg agcaccgttt ttcacgagct cgaaacccct tcaatccaaa acctaatcta 2767981 tcatatcggc tgcagaatat tagcgaggtt cccgcagctc actgatgtca gcttccaatc 2768041 tcaaaatcac acgtgggata cggttgtcga agaaatcccg ggctcaaaag gaaaagtcta 2768101 caccgaaccg cgcccgccat acggtttcca acattttacc gtgacaagag aagacgccga 2768161 gaaagaaaaa cagaaagccg ctgaaaaatg tcggagcctg aaagcctgat gggaaaactg 2768221 acaacccata ttttagattt aacctgcggc aaaccagcgg cgaacgtaaa aattggattg 2768281 aagcggctgg gcgaaagtat tatgaaagag gtatacacta acaatgacgg cagggtcgat 2768341 gtccctctgc tggctggtga agagctgatg tcaggagagt atgtgatgga atttcatgca 2768401 ggagactatt ttgcgagtaa aaacatgaac gcagccgatc agccgttttt aaccatcgtc 2768461 accgtccgtt ttcagctagc agatccagat gcacattatc atatcccgct cttgctgtcg 2768521 ccgtttggtt atcaggtgta tagggggagt taagaaggaa gcccgcctca ccggcgggct 2768581 tctttttgca cttcaattaa cttttgatcc taggacagta cttgaagtga tccccacact 2768641 tagtgaaaca acagctagaa taaacattca cctatatttt tcaggataat tgcctacgag 2768701 aaaaataccc tgtagtcctt tcatttataa atcgaggttt caaactaata agtcagctct 2768761 tagcagccga gctcccttct ccaatcctat aaacagaccg cgttttttct cgaaaaaata 2768821 ctctgaagac aattgctgcg tttttaatag ttttgataac gcgttctctc ttacaccttt 2768881 agacaaaata ttcatttttt cttttttaga cttaaatcta tgtcgaaaat aatcgttggc 2768941 atatcttatc ctatctccac taaaggaggt gacattatgg gattctacaa ttctggtgga 2769001 tacagtggaa actctggtta ctcaaacggt ttcgggagct ccttcgcttt gatcgtggtg 2769061 ctattcattt tgttgatcat tgttggagca gctatcttta attattaagt ttaactttcc 2769121 ttgcctccgc cgtatccaac acctccctgt ccgacagacg ccataagaag tttttatggc 2769181 gtctttgcta tgtgttcact aatctttttg taatccagaa gctgtcaagt tctacgagat 2769241 ttatcgtgtg ttttcccaca acgcttctgc gtcttgatcg cgctgtctga ctgaggctaa 2769301 aaaagtccgg cttttaaaag ccggactccc gtctaccccc gttcaactct cttctaatcc 2769361 tgcaagctga ccgcataatc ccgccatacc cggtacaccg gcacaaattc cccgccagcc 2769421 cttcttctat atctttgtca gaaggttgag gggtttcccg aaacaatgct ttaagcgcaa 2769481 tgatcattcc cggcgtacag tagccgcatt ggaagccgcc ttcttccagg aaagcggttt 2769541 gacacatatc cagctcttct ttttgaagcc cctcgatggt tgtgatggaa tggccgtctg 2769601 cttgataggc catcgtcatg cacgcattgg ccagttttcc gtcgattaaa atagagcagg 2769661 ctccgcagcg gccgattccg caggacacct ttgtcccggt cagctgaaat tcctttctaa 2769721 gcaggtcact cagatgtgtc gtaggaacgg cagcaacctc ccacgcctga ccattcacgg 2769781 tcatccggaa ctgttccttt tttacaggaa atggcccggc ctcttttatg tccattgctt 2769841 cagccccttt ctgtcgatcg cttcaagcaa ctcttctctt gaaattggca gcttgtttat 2769901 ccagcatccg accgcatcat gtactgcctt tacaatcgcc ggagtgatgg cgattgttcc 2769961 gatttcacca acaccgcgcg gtccatatac gtctcccttc attaagtctt ctattgcaat 2770021 cagcttcatg tcaggaacat ctttgattcc gggaatcaaa tagtgatcga gattttccgc 2770081 agcataacgg ccatccgtca ttttcgcttc ctccatcagt gtgtagccga gtgccatggc 2770141 agcgccgcct tcaatttgac ctcgatatcc ctgcggactg acaaccggac ctgccgcaat 2770201 agcgtgctca caatctatca atttgacatc gcctgttaac agatctacct ccacctcaac 2770261 ggcagccgct ccaaatgagt agaggaaatg gccgcccacc acaggatcag gcgttgttgg 2770321 aaagtcaaag gccgtttcct ctgccaaagg gcctttttca gccagctcct tatacgtcac 2770381 cacgagcgcc tttgtgtttt tgtcacgcaa gcctgcagcg ccgggaataa gattttccgc 2770441 tgaacagccg ctccattctg ccgcccgttt tttcaactga gctagaaacg gcttcttcaa 2770501 acgctggatc gcgtgccaca ccatgcttgt gccgcgggat gctgtggagg agcctgactt 2770561 cggcactttt gcggtatccc caataacaat ggaaatatcc tctgcggcac aacccagctc 2770621 ctccatgaca atctgttcaa tcgctgctag aatcccctgt ccgcattctt caaatccaaa 2770681 cgaagcagtg attttgcctt cactcgaaag agacaaacgg cctcctgccg catccattcg 2770741 gccaaacccc agcccgccgc cgtgcattgt aattgccgct cccgtgcctc tttgcagata 2770801 cccgcagttc cggcttgttt ttttaagaat gggagattta gatatggcat tcaacacctg 2770861 tgccgctccg tcagttggtg caattcgatg ctcaagcggc cccaagtcat gcggttttct 2770921 gatatttttt cttctcagct cgagcgggtc gatgccaagc atgccgctga gacgatcgag 2770981 atgggtttcg agtgcaaatg tgatttggtt gccgccaaag ccccgaaatt cccccgccac 2771041 cccgttgttc gtaaatactg atattccttc agtccggata ttcggaatac ggtacggccc 2771101 cgcggcatgc tcgacagaaa aatcaagaac agccggtccg agcgtagcgt aagcgcctgt 2771161 gtccgccaca attttcacgt cgtgcgccaa tagatttccc gaatgatctg cacccgtttt 2771221 tatcgtaatc ttcatcggat ggcgcttaat gccagaacgt acagattcct ttcgtgtctg 2771281 atgaattttg acagggcgtc cgcttttcag ggccaaaagc gcagcatacg gctgaatatt 2771341 cagctcatcc ttccctccga acgagccgcc catcggactt gacacaattc tgatcttctc 2771401 ttcaggaata tcaaaaatac gggcaagctg gaaacggtct ttatagccgt gctgggttcc 2771461 tgcatacatc gtaaaacccc cgtcgtcttc cggaacggct acacctccct ccgtttccat 2771521 atacgtatgc atctgccgcg gcagctcata ggtttcttca aagactgtgt cagatgcttg 2771581 aaacccttct tccacatcac cgtttgaaaa aaatgcgcgg tgcaggatat tcccgtcctc 2771641 atgcagtctt tgcgcattcg gccgaagcgc tttttctggt gaatccatga cttccagctc 2771701 tttatactca acttgaatca gctccagcgc cgcttccgcg atttcttccg tttccgcagc 2771761 aactgcggcg atcgcatccc cgacataccg caccctgtcc tcacataaaa ccggctgatc 2771821 agggatgaca atgccaaatc ggtttaagcc gggaacgtct ttatgtgtga cgacggcctg 2771881 cacgccttcc attttctcag cttttatggt gcaaaccgac acaatctctg catgaggata 2771941 agcacttctc agcaccttgc catacagcat tcctggaaag ctgagatcgg tcatatattt 2772001 caattcccct gtgaccttac cccttccatc cggcctgact cttgacggtt tgttgatgat 2772061 catttattcc cctccctcag ccatcagctc tgccatgatg acgttggcag cggctttttt 2772121 tctgtatgcc gctgacataa aaacatctga ggaaaacggc agctcatgga taagtgtttt 2772181 gtacagctca tgcgggtccc accctggtgc catccatttc gcttcgctgt ccaataatct 2772241 cctaggagtg atatcggcat ggccagcggc gaggcgaatg ctgccgtctt tcaaaaaacg 2772301 tccagctgca acagcagccg ctccggtaaa agcctggcgc cttccaagct tgtgataaaa 2772361 tacacgctct ccctccgccc gcgggatgat gacacgcgtg acgatagccg ttctaaagtc 2772421 ttcctcactg agccaagcgc caagcggcag cctgattagc tccttttgat atacgataag 2772481 ctcagcacca agcacaagca gaagcggaat gaaatcaccg attttactcg ctatgttgcc 2772541 gccaatcgtg gcacggctgc gaatccccgg tgcagcgaca gcggaagcag cgtcactgaa 2772601 acagctaagc gctctcttaa tcaaagggtt ctttctgcat tcattcagtg atgtgagccc 2772661 cccgatcgac acgtgggtgt cactggtgct gatccctcgc atttcgtcaa tcccttcaag 2772721 gctgacaagg tgctgtttcg gtagagttcc tttgtcccac tgaagctgaa ggagcgtgct 2772781 tcccgatgcg gcacacacat ccggagcaag cttctctaaa agcgaatagg cctcatcaag 2772841 cgctgccggt ctccataatt gaatattcat ccttgctttt gtcacttggc cgttcaagac 2772901 atcgccctcc ttaccatgtc atattcctcg ggtgtatcaa tatcgtccaa ctcaccgcta 2772961 tcctttgcct ccaaaaccgc tcctgctcca agctgtccgc ttttcaggag cctgcgagcc 2773021 ccttcatctc cctttaatcc ctttacataa ggaaaacatg tcgacgagaa gtagattggc 2773081 ggggtgaacg cccctaaaaa cgatgacacg gcaaatgact caggagccag agccacaagg 2773141 gcattgagat gatcgacgga aagctgaggc tggtcggcta acaaaatgac aatgccgtcc 2773201 gcccccatgc tttctgcttt tctcaccccg ctgctgactg aatgcccctg acccttttct 2773261 gcgtcttggc aaacgtgcag gctccagcgt ttttgaaaag gcggagcgtg atacggcgct 2773321 cctatccact caagggaggc atgttctgtc cgctcgacga ccagcacgtg atcaaggcgg 2773381 gacgacagag cagttttcaa ggaaagtgag cctatgtttt ctccttttag cggcaaagcc 2773441 agcttgtttt gtcccattct tctgcttttg ccggcagcga gaaacacgcc gatcagatag 2773501 gggcttctca tacaaccgcc acccgttttc ttgtttgaat gatttctgca actacactta 2773561 ccgcaatttc ctcgggacct tccgcaccga ttttcagccc gaccggactg taaaagtgag 2773621 acggaggatg ttttccgctc agcagccgtt tcgtgcggtt tgccgaaccc aacagtccaa 2773681 tataatggag gttttgagaa aataagaagt tgatgatcgt ttgatcgtgc tgataatgat 2773741 gggttgccac aacagctgca tcatgcggaa aaaattgaaa ttcgctaagc atttgttccg 2773801 gaaaagcggt gatcagctga tccgcttttg gaaaaagaga ggatgtacaa taagcgggcc 2773861 gccaatccgt cacgataaca gaaaaccctg tgtcagccgc caaattggcc agcggtacat 2773921 tatccggtcc cgccccaaac agaatgagac gcggcttcgg ttcaattcgc tgaataaaca 2773981 tgttagtggt ttgatcgaaa tgcggtaaat gaagcgttga aacagtacgt tgaatatctt 2774041 gcagaggcgc gtccggccag ttcccaaaat gtccgttctc cgtcagaaat aaataatggg 2774101 aggattcaat ctttataacg gaagtgacag ctttgcctga atgaaggcag tccctcactt 2774161 tctcatagtg ccgccttttt tcctgagtga ttcgctctgc atgaacatga ataatgccat 2774221 tgcacccggc tcccatgccc caagaaagat cgtcctccga ccgcatgtcg tagggaatca 2774281 gcgttgatgt gagctgatcg cccagcgcac tgattctttg gaatacatct tcttccacac 2774341 acccgccgct cagcaagcca atccgtctgc cttttttctt aaagagcata gaggcgcctg 2774401 cttttcgata cgcggagcct tcaacttgaa caattgtcgc cagtacagcc tcctcctggt 2774461 cttccaggag cgcatctaac atcgtgtgaa aattccccaa tgccgcatcc tcctctcgaa 2774521 aattgccgtg agaaacaact agttcagcgt gattttatag gtaacttgta taaagaatag 2774581 acgatggaag aaaaaatgac tcatgatttg tcagaaaatg aaacacatag aaagaggatt 2774641 tgtaaaaaga gtcaaacgaa gaaaatcaga ttggagaaaa cacgaaatca tatcgttaaa 2774701 aagcttgcgg agttccgcaa gcttttcttt acaccgctgc ctggcggcca gcgttttcat 2774761 acacatccag cgctgcttgg agcgcttttc ctgcttcgat tcctgcgtta tgtctgagaa 2774821 gcacagcctc taacccggca agcacgaata gcacgttttc ttttctgcag ctgtacccca 2774881 tcgtgccgat cctccagatc ttccctgcaa gcgggccgaa tgagctggcg atttcaatgc 2774941 cgaattgtgc cagcagcatg tcacggacag actcgccgtc aatgccgccg ggaatttcga 2775001 cacaggtgac aacaggcatt ttgcagctgt catctccaaa caatcttagc cccattgcct 2775061 ttatccctgc tgctaatgcg gcttcatggt gccgatgccg ctcgaaacgc gtctcaagac 2775121 cttcttcaag caccagtctg actccctcac gtaaggcgta cagcatcgtc gtcgcttctg 2775181 tatgatgatt gagccgtctt tcgctccaat aatcctcaag ctggctcaaa tcaaagtagt 2775241 tgcttgtaat tggccgattt cccgaaagtg ctgccctgtc agcttgtgtc gcaatcccgc 2775301 gttccacctt tttgcgagct gcaatcacgt ccgccacccg ctcattatat gtaatcggcg 2775361 ccattcctga aggcacagac aaacattttt gcgttccgcc gatggcagcg tcaatcttcc 2775421 attcatcgac tttaacctcg cagcccccaa tcgttgcgac tgcatcgacg ataaacaatg 2775481 catcctcggt gcggcaggct tcgccgatgg ctttcagcgg gtgaatccgt cctgtcgatg 2775541 tttctccatg caccatggcc acaattttcg gcttcacttt ttttatctcc cgtatgatgt 2775601 cctccgggtc aaaaaccgtt ccccattcgc actccagcat atgaacattt gccccatatc 2775661 gctcggcgat ttcagtcagc aaataaccga aacggccgta aatgggaatg agcacatcat 2775721 cttccggctc tatcacacta gccagcactg cttcaattcc cgcccgtgaa gtgccgtcaa 2775781 tcgggtatgc ccagcggttt tttgtttgga acagctcccg aagcatctcc atcgtttcat 2775841 tcataatacc tgtaaacgcc ggatcaaatt ggccgacaac cggggtgctc attactctta 2775901 atacacgcgg atcaacctca acaggccccg gtgtcataat cgttcttaac ggggtgcata 2775961 attctcttct gcctgacaca gccattcctc ctttatcagt aagccagttt gtataataaa 2776021 tcagtcagtg cgcggacgcc gatctcaagc tgtctggctg acgtatattc cttcggtgag 2776081 tggctgacgc cgcctcggct cggcacaaac agcatacaag caggatagcg ccttccgatc 2776141 atttgcgcgt catgccctgc tccgctcacc atttcctcac agctgaagcc gttttctaat 2776201 gctgtttcaa aagccgcagc cttcagcctt tcgtccatcg gcacaggctc tatccgcata 2776261 tattcatcaa tcacagcgcg aattcctttt tgtaggcaaa tgccgttgat caaagcaacc 2776321 atgtcttgat gaaactgttc cagcacatgc tgatgctgat ggcgaatatc gattgaaaac 2776381 tggacgcggc ccggtatgac attggctaca ttgggctctg ccgttatttt tccgcatgtc 2776441 agacggagct catccggcag ctcatccgac cgcagcagca gctcatgaat gatacggctg 2776501 ctggctgcga gcgggtcctt gcgccatttc atggaggtgg ttcctgcgtg attgcattct 2776561 ccttcgagcg tgacgagata tcgtctctgc cccgcaatac ttgtcacgat gccgagatcc 2776621 cggcctgaca tttccaacgt cttcccctgt tcaatatgca gctcaacaaa cgcgctgata 2776681 tctgtcctat atgctgactg aaacacacct ttgccaaaac cgctctcatg catcgctgtt 2776741 tggagggaga ctcccgactc gtctcttggc tcttttgcat cttgttctga aaaaacaccc 2776801 gtcatattcc ccgaccccca ataggtcatt ggaaaacggc tgccttcctc ctcacataag 2776861 gagaccgcct cgagcgtttt ttttggcgct ccgtatgttt ccttgagctg ctttaacgcg 2776921 agcattgccg ccagaacgcc ataggcgccg tcgtattttc ctccattgat gacagtatcg 2776981 atatgtgaac cggttacaat gacttcatcc ggagactggg tgcccgaaag ccttccaaac 2777041 acattgccga catcgtcgaa tcttgtttca agcccgaaag aagacatttc cgttttcaca 2777101 gcaagctgtg cgtccatcca ctcttttgtg tataaaagcc tcgttacgcc gccatccgca 2777161 gacgcaccgt attgggcgag ccattcaata taatctgtga tgctgttttt tactgaaagc 2777221 ttctgctttt ccatgtactc ccccctctgg ccgctatggt gacttcatta tagaaggagc 2777281 aacatgatag ttcattgaca gattaaccaa aaaaacgttt attttttagc cacagtatcc 2777341 atccagcaac cagatacacc ctacatgtca caactatttt gatgtaaagg tcaaaagaaa 2777401 acacggtaag gaagagagcc agcaagagcg aaagagaggg tcaaaatgcc tttcatatga 2777461 acaagctaag ctggagaggc gatgttcgcg gaacggatga aaacagaaat gccggcagcc 2777521 cgcaaaaaca ggacctaaag atatggaaac aggagatttc cgcctcctcc aaagggacta 2777581 atttacaatt ttaatgaaaa atatacaaaa tgacacttct atcctttatt tcaattttag 2777641 ataatagata tgatctgata aaaggagggc aagtgatgac aaaaaaagca tggtttctgc 2777701 cgctcgtctg tgtattactg atttccggat ggcttgcgcc agcagcttca gcaagcgcgc 2777761 aaaccacatt aagccttaat gaccgattgg cgtcttcccc ttcaggaacg ggaagccttc 2777821 tctcattagc cgcccccgct gcaccctatg ctgacacaga tacctattat gaaggggctg 2777881 aaggtaaaac aggagactcg ctaaaaagca ccctgcaccg tattatcagc ggacacacga 2777941 tgctgtccta cagcgaagtg tggaacgcgc tgaaagaaac ggatgaagac ccaagaaatc 2778001 cgaataacgt catcctgctc tatacgaatg aatcgcgttc caaaaacctg aacggcggca 2778061 atgtcggcga ttggaaccgc gagcatgtct gggcgaaatc ccatggcgat tttggtacga 2778121 gcaagggacc tggtactgat attcatcatt tgcgcccggc tgatgttcaa gttaacagcg 2778181 ccagaggaaa tatggatttt gacaatggcg gcactgaata tgcgaaggca cccggaaatt 2778241 attatgacgg cgattcatgg gagccccgcg atgatgtgaa aggcgatgtt gcccgcatgc 2778301 tgttttacat ggctgtccgt tacgagggtg atgacggcta tcctgatctt gagcttaatg 2778361 ataagacagg caacggctca gctccttatc atggcaaaca atctgtcctg ctcgaatgga 2778421 ataagcagga tccggttgac gaccgcgagc ggaaaagaaa tgaaatcatt tatgaaaaat 2778481 atcagcacaa ccgcaatcca tttatcgacc accctgaatg ggcggatgag atttggccgt 2778541 aagaaaaagg tgctcctttt gaggagcacc tttttctaat acacagcctc ttccgtttcc 2778601 gcatcgaaaa agacgacgtg gtccattttc actgagagct ggattgaatc gcctgcatcg 2778661 attcgcgtgt ttccgtccag gcggaccttg agccgctcgt ccccagccat gacatgcact 2778721 atgagctccg agcccagatt ttcattcact tccacgttcg cttgaaacac tgaatcaaac 2778781 aactggtcat ttcctgtcat ttgtgtgatg tgctccggcc gtacaccggc aatcatctgt 2778841 tctccggcat atcccttttc cttcagccgc tttgcttttt cttcaggaat atgaagccgg 2778901 atcgaagaat ttgtgaaaaa cagctcgcca tgctgctgtt ctatgatgcc tttcaaaaag 2778961 ttcattccgg gagagccaat gaagcctgcg acaaacaaat tggccgggta atgataaatg 2779021 tcatgaggtt tcgccacttg ctgaatttcc ccttcattca tgacgacaat ccgatctccc 2779081 attgtcattg cttcggtctg gtcatgcgtg acataaatga tcgttgcctc taatcgctgg 2779141 tgcagcttgc tgatttctgt ccgcatcgtc actcttagtt ttgcatccag attagaaagc 2779201 ggctcgtcca ttaaaaagac cttcggctcc ctcacaatcg acctgccaag cgccaccctt 2779261 tgccgctgcc cgccggagag cgccttcggt tttctcttca gcaaatgttc aatttctaaa 2779321 attctggctg ccgcatgaac ccgctcggca atttcctgtt tcgccatctt tctgagcttt 2779381 aatccaaacg ccatattatc aaaaaccgtc atatgcggat aaagcgcata gttctggaat 2779441 accatcgcaa tatcacgttc tttcggcgga agatcattga cccgctcccc atcaataaga 2779501 agatttcctt cagaaatgct ttctaatcca gccaccatcc gcagcgttgt tgattttccg 2779561 catcctgacg gccccaccag caccaaaagc tccttatcct ttacatctaa atcaaagtcc 2779621 ttcacggtta attgtgagtg atatgatttt ttgacgtgtt caaatgttaa tgaagccatc 2779681 agaaaagtcc ccctatcttt tgacccgtta tttcgtcact ggaaacaact tggtctttct 2779741 gttattttta gagtaatcga ttcccatttt tgctatattt ctaaaataaa aaatgtaaat 2779801 ttgtattata acgtcataat acattataat ataaataata ggttaaaagg aggctaccct 2779861 ttgttaaaca acggaagttc tacaccttta tacattcagc taaaacaaat catcactgat 2779921 gacatcaaaa agggcgtgta ttccccaacc gccaagctgc ctaccgaaaa cgagctttgc 2779981 accaagtata acgtcagccg catcaccgtc aggaaagcca ttctcgattt agtcgaagaa 2780041 ggctatctga tcaggcagca gggaaaggga acgttcgtta aaagccctaa attaaaacga 2780101 gagctgatcg ctgtaaacgg ctactcggaa tttatggaat caaccggcaa aaaaccgaag 2780161 catcatgtgc tgtcccatga catcattcca gcgtcaaaac ccatcgccga aaagcttcaa 2780221 atccaacccg agagccctgt ggttgaatta aaacggattt tatataatga tgatcagcct 2780281 ctcacctttg aagtgacgca ttatccgctt gatttgtttc ccggcattga tacctttatt 2780341 gctgacggcg tctccatgca tgatattttg aaacagcaat acaaagttgt acccacgcac 2780401 aatacgaagc tattaaacgt tgtatatgcc caacaggagg aaagcaaata cctggattgt 2780461 gatatcgggg atgcgctgtt tgaaattgat aaaacggctt ttacatcaaa cgaccagcca 2780521 atctattgct cattgttttt gatgcacaca aaccgtgtca cttttaccat caacagcccc 2780581 tacacataac aggcataaaa aacgagacac tgcttatagt attctcgttt tttcactgct 2780641 tcccccgtcc tccaagcgat aaggatagcc atagccgaaa gctccgtaca caccgcaagt 2780701 tttcgcagcc gtttcagcag cctggcgcaa agcatacgtt atatcctgct tcacgcaaaa 2780761 ggcagtcaaa aagcctgcta taaaagaatc tcccgctcca agtgtatcta ttatatcagc 2780821 ttccacaatc ggctgatgat agactcgatc acccgcagac aggattgctc cttggccccc 2780881 tcgggtcata caaaccattt tggctccgta cccatgagct gttttggcaa gctcaccgca 2780941 ttccgactca ctcaaatcgc ttcctgaaaa aaacgcatac gtcacataag gacagaccct 2781001 cctcaaataa tcatcctccc gattggttga aaaatcaaat gagaccggga ccagcccgca 2781061 cagctgcgga agatcgttct caagcctgct gtacacgctc gtatgcagca gatcatgccc 2781121 gctgataaaa gatacatctt tctcctgaaa cgcgaggcga agccgggact gaatgccgcc 2781181 tttatttgat ctgacaaaaa tgcggtcccc ctgttcatca agggtgacaa tcgccatccc 2781241 gttttctccg tgcgcctggc ggatataatc tgcattgacc tgctccagct tgagaacgtt 2781301 caacagatgc gccgcggctt cgtcattgcc gacgattccg atataggaag actcatgccc 2781361 gagccgcttg gcaagcacag caacgtttaa ggcatttcct cccgggtaaa atgtttcttg 2781421 atcctggtag taatctacaa cattatctcc aaccgcaatc aatttcatag cgcttcctcc 2781481 tttatccttt tacactgccg cttgcaatcc cgcggacaaa atatttctgc atcaataaaa 2781541 atagaataat aatcggcgcg gctgaaatcg ttaaccccgc cagcaggacg ccccagtctg 2781601 tctgcagcgc gtctctgaac tgcatcagcc cggctggaat ggtccgtaaa ttctcatcat 2781661 ctatgaaaat aatcgcaaac ataaactcat tccatgtatg gtaagccgtc aaaatgccgg 2781721 atgtcaccaa aatcggcacg ctcattggta agaaaattct gaaaaatact ccaaaacttg 2781781 tacacccatc caaataggcc gcctcctcca attcttttga aatagaaaga aaataagagc 2781841 ggatcaaaat gatggtgaat gggatccgat aagccgcata cggcaagatt aacgcccaat 2781901 acgtattgta caggcccagc gactgaataa tagaataaag cggcacaaga ctgacctgcg 2781961 gcgtcagcat caatccgcca agacatagca ccaaaaagaa tccttttcct ttaaactcaa 2782021 accgggaaag gccatacgct gcccatgcac tgataaagac agtgatcaca cacgtcagcg 2782081 ccgtaacgat gacactgttc ataaaataag aagaaatccc ctgattccag gcggaaacaa 2782141 aattttccgg atgccacgaa gacggcagcg accagctgtg ctcaaaaata tcgtcagagt 2782201 ttttaaaggc gctcatcacc atccagagaa gcggataggc aatcgcaatc agataaagaa 2782261 acagaaaaac ccacacagac gtttctccga tataccattt tcgtctaggc ttatctttca 2782321 cctcaatgtg ctggtcaggc accggctcca atctgaacga atctgtcttc ttctgaggca 2782381 gcatcagtta ctcctccttt ccggttttaa agaacttcat ttgcatgagc gataatgcaa 2782441 gcgtaatgat taacacgaca gtggcaatcg ctgaggcgta gcccatcata tcctttgtaa 2782501 aggcgctttt atataaaaac gtgctcaaga cttctgacgc ttttcccggc ccgccgcctg 2782561 tcaaaatgta cggctcatta aagaccgtaa aggctccggt cagcgtcatg accaccgcaa 2782621 caaaagacat ctctttcgtc tggggaacag taatatgaaa aaactgctga attttacccg 2782681 cgccgtcaag ccgggccgct tcatacagtt catccggtat tttttgaatc gacacgatgt 2782741 acagcatcgc aatataaccg acagattgcc actgggacac aaaaatgaca gaaagcatag 2782801 ctgtgctgtc atccccgagc caggccctcg tcagctgatc aagaccgatg gcctgaagca 2782861 gctgattcaa aagccctgtc tccggattgt aaataaaatc aaacaaaagc gcgatcaccg 2782921 tcattgagat gacaaccggc aaaaagaaaa cggtacgaaa aaacggcgac cattttctga 2782981 ccagcttatc ctcaagcacc gccgccaaaa tcaaaccgcc aaatacctgg catacaattg 2783041 agatcactgc ataaagcaca ttattggtaa gtgcctgata gaagacagga tcatgaaata 2783101 attcaacata gttttttaag ccgataaacg ttttttccgg agaaaatgag ctccactgaa 2783161 acaggctgag gaatacattc tcaaaaatcg ggatataaac gaaaagtaaa aaaacgagag 2783221 cgggcaccaa aaacaaatag gggattattt tattctgatt gaccaagggt atctcatctc 2783281 ctttataaaa agaaaaggtg cgaagcttca ccttttcttt gatttattca gctgacgccc 2783341 tcacctgctt tgctgccttt tgaacggctt tcatcacctg ctgcggtgtc atgtcgccgc 2783401 caagcatttg ctggacgccc gttaggtacg catctgcgac ttcaacatcg acatccatat 2783461 caaaccatgg aaccattgat ttggcatcaa caatatgctg aacggcttca cgctgaatgg 2783521 ctgttgcatt ttcttcagta gccgtacctt gcactgcact gtatttcccg acatctttca 2783581 cgagcttttc gcccattctt ttcgacgtca agaactgcaa aaattccatc gcttccttcg 2783641 gatgttttgt tcttgaggag atcatgaatc cttccggcgc tcccgttaac gcttctgaag 2783701 atcctttctg cccgctgatt tcaggaaatg ggaacatccc gagattaacc ggttcaacca 2783761 gcttgatttc cgctgtttcc gcatatatca tcgccgactt tccgctctta aattgctgtc 2783821 tcacatattc gtggtcgacg gagtttacat gtttattaaa gtaaggcatc agctcttgaa 2783881 gcttttcaag tgcttttacg tagccttcat cagtaaattc acccgttttg gcgttatagt 2783941 ccttttcccg tgttttttca tcgaccatcc gctgattaag cgtgccgata tagtgcgaga 2784001 ttgtccaagt cgcctttgtt ccaaagctga tcggtgtgta gccatgttct ttcagctttt 2784061 ttgacacatc gattaattca tcccacgtct tcgggggatc aagattcagc ttttggaaaa 2784121 tgtctttatt atagaagaat gatttagcgt ccatttgcca cggtacgcca tattgcttgt 2784181 tttcataagt aaatggtgta atttgcgatt gaacgagctg tgatgaccaa tcggtgtcat 2784241 ttttgtagta ggacgagaga tcaagtgctt tattgcctct gataaattta aaagcaaact 2784301 catcgctcca agagaagtaa atgtcaggag ggctggtggt tcccagcatg accttaattt 2784361 tatctttata ggagtcattt aaaacggctt caatttgaat gtcgatatct gggtgatctt 2784421 tttcaaattc cttaacaacc tcttcaaaat aacttttttc cggctccttt ggccatctgt 2784481 ggaaaaattt caatgtcacc tttccgtccg ctgaactgct ttggctcgaa cagcctgcga 2784541 tggtgagcat actgacagct gcaatgatca agaacaacaa cattttcttc aaagggttgg 2784601 cctcctctgg acattagact ataatgttat ataacattat agtctaatgc ataatggttc 2784661 ttcattttca gatcaatact caactttcca catgtatctt ctatgagata aaggatgatt 2784721 tctctcctct gccagctcgt ctgcatagct tctcagcaca cgattgagaa cgagcggagc 2784781 aagatagcct ttaactgaat cgtcaattgc agtgaagtcg taagatgcag catcaagcac 2784841 agtgagcttt ttgccatact ttttcgagaa ggtaagcgcc cgctcttcaa gaggtcttgt 2784901 ttcatctaaa ccgagcagga tgataaacgg cacggattca tcaataattt caaacggtcc 2784961 gtgaaaatat tctccggcat gaatggcgtg ggaatgaatc cattgcattt ccatgagaat 2785021 gcagatgctg taggagtaag cgacaccgta gtttgcaccg cttgccatgg tataaataat 2785081 gctttctttt tcatgggctt ttgcaaattg cttggcgttg tcagcttcct gcttaagggc 2785141 tttttcatat acagcctgca attgatctaa gccttcaatt gcttgctcaa atttcgtatt 2785201 gttttctaat acttgcaggg ttccaaaaac gatttgatac aaaacgccat agtttgtatt 2785261 gatcgcaagc gcctcatcac cccaatcgta ctgggcaaca tattgcgctt cctgcgctaa 2785321 aggagactcc ggtttaaacg tcatcgcaat cgtaagtgcg cccttgcccc ttgcaaacgc 2785381 agcagctttg actgtctccg gggtatttcc cgaatgcgag cacaaaataa caagagactt 2785441 ttcaccaagc tgaacagggt tgcgctgaat aaattcgttg gcgctgtaga gatcggagtt 2785501 tattgatttt gactctctgt caaacacata cttactcgga tacataatgg cagaagaccc 2785561 tccgcatgcg acaaagaata catgatcaat ggttttccct ttcaaatcct gcaagaaagc 2785621 ttgaacctca cgatttactt ttgctgtggc ctgactcaaa tccttcactc ctcgttttta 2785681 ttatataacg ttatataaca ttatatattg ttatattaaa gtccgcgggt aggattgtca 2785741 atattatttt ctgaaatttc tcaataattt attcggatga cagacaaagg gtctatatgc 2785801 gaaaaaatgc ccaaatcaaa agccagaact tgacttaagc tctggcttcg ctgttcaatc 2785861 cgcagactga cgtcttattt aaaaaatacc ttgtctatat tgtacttcga gtgctgtgta 2785921 ttgatgatat atgtttcgta aatctctctt tccattggat catcaactac acatacctca 2785981 attttataaa cttcatctct gtgatgtttg atcggtgaaa cagtgtcttc gaaatgcttc 2786041 ttaattctct gtcttaactt tctggcttta ccgacaaaca gcagctcgtc atgaatgttg 2786101 taaaacataa aaatgccgcc tttgtccctt gggatctggt gaaagtcgat gaatccgtga 2786161 atcggtttta tcttcggctc gttatcatta gctgactgct gtcgttcagt gatggtgaca 2786221 ttcggtgcgg gtatatcaat ttttatcaaa atcagttcac gtcctctttt tcattaaaga 2786281 taaatgctaa cacatacaga aaagaaaagc tagaacagct ttattatatt tgtttgtcat 2786341 gctcttactt attatgcaag tgctccggct ggatcataag gactaaggtc taattctgtc 2786401 tgctttccga gaactagctt tgcgagctct gcacccaaaa acggccccat cgtcagtcca 2786461 gaagcaccca aaccgtttgc agcgtacagg ccttgaacat tcggcacggc ccctacgacc 2786521 ggcagaaatc ccggtgtaaa cggcctgaag cccactcttg tttcaacagc agccgcatca 2786581 gcaagacccg gtgcaacggc taacgctttg ctcaatactt cgtgctggcc tccggctgtc 2786641 acacgaagat catcaagacc ggcatcgttt tcgtgtgtgg cgccggctac aattctgccg 2786701 ttatcaaacg acagaatgta ctgatcactc ggcggcatta caaccggcca cgatcctgta 2786761 tctgcatctg tcatttcaaa atgcataatc tgcgcttttt gaaatgacac ttgaaaatga 2786821 atgccaagag gcttcaatat ctcattggcc catgctcccg ccgtcacaat gaccgcgtca 2786881 gccgcaaact gctttgtatc tgtttgcacg ccggtgactg ttccgttttc aaaaagcaag 2786941 gacgcatttc ctttgatgac cgttgcgccg cgtttctctg cagcgcttaa aagcgaccgg 2787001 cacagcgctc ttccgttcac acgggcggca ccgctgatat gaaccgattc atagccgtca 2787061 gctaaaatcg gaaacagctt tttcgtttca cttgcagaca agcgggtaat gtcgccgatt 2787121 tccggcgcat cctcccgtct cttatacgcc ctttcctcca ttttatcgag tttagacgcg 2787181 tcagtatgaa tgctgatggc accgacacgt ttgtatcctg tatccgattc accgtctttt 2787241 tccaattgat ggattaaatc cttatagtac cgcgctcccc ccttagcaag ctggtaccaa 2787301 tcctgattac ggcgctgcga gagccaagga cagacgatcc ccgccgccgc atcagtcgct 2787361 tgtcccggct ctttccgatc aatgacagta acgcgagcgc ctgtttttgc gagatgataa 2787421 gccgtcgacg cgcccagaat ccctgcgccg acgatgatgt acgatttcat atgcaaacac 2787481 cttttctatt ataatgtcta ttcattttac caaatcaaat gctttccttc gaccttttgc 2787541 cctaatgtgg aaaaaccgcg aagttcgtcc aatctcttta ctctcctatc gaatatcctg 2787601 tcactatcaa tagagaaagg atgataccat gagcgaaaat cgtcatgaaa atgaagaaaa 2787661 cagacgcgat gcggcagtgg caaaagtcca aaacagcggt aatgcaaaag tcgtggtcag 2787721 cgtgaacaca gatcaggatc aggcacaggc gcagtcacaa gacggagaag actaatgaac 2787781 gaaaacatca ttcctcttaa cagacatact caagagatac ccactactga atctgttatc 2787841 aaaaacagcg gcaactcaga ggtccatatc gacattcaca ttgatacaat gccaattgct 2787901 tttgctatat tatgctctgc attagccgca aagcagatga caaaagagga attcgatatg 2787961 gcttatactc aattgcgaga gatgaacaga gaaaataaca gcagatcatc tgtaaagcaa 2788021 attatcaatc aagagacaga agaagagtaa aaaaccgcgg cccctcggcc agcggttttt 2788081 cttctgcata caaaaaggac gcgactgaat cggttacttc tgtacaattt gaataaggtt 2788141 accgcatgta tcgtcgaaga cagctattgt gacttcgccc atttttgtcg gttccgtcgt 2788201 aaacgtcacg cctttttcct ttaatcggtt gtactctttt tgaatatctg caacgccaaa 2788261 cattgtggcc gggaggcctt cggagaatat cttcttttga tactccttgg cggcaggatg 2788321 ttcattcggt tcgagtaaaa gctcggttcc gtcttgatca tctggagaaa caagcgttat 2788381 ccacctgaat ttccccatgg gaacgtcttc cttttttata aacccaagtt tttctgtata 2788441 aaactccagt gccatgtctt gatcttgtac aaatatactg gtaacaacga ttttcatact 2788501 gtttttccct ccttcgatat gaatgaagca tggtactatg ctaacaatct ggctacaagc 2788561 aaaacaaccc acacatttat cagaggccct gttctgattt tataaaatta ttctatccat 2788621 cctttcagca aatttttaag cggttcgttg ttgaatataa gtactcgata ttttcccttt 2788681 cgttttgatg ttacgagtcc tgcatcctcc agtacagaaa ggtgtttagc tatcgcctgt 2788741 cgcgtaatag aaaggtcgta ctttgtaata agacgtatcg taagttcata caacgtcagc 2788801 tcgttgcgtt cagataattc gtctaatata agccgccgag tcgaatcgcc gagtgctttg 2788861 aatatagcgt ctttgttccc attcatatat tgagtataag caacccatta gttgcatgtc 2788921 aagtataagc aactgtatgg ttgcgtgata tagaaactga acctatccgg cgcaggtctg 2788981 aaatattcta atcgataagg aattaaaacc attaaaataa cagtggatat gtctctgaaa 2789041 aataaaagaa gacgaacttc aaaagttcgt cttctacaat caaattcggc acgccggcca 2789101 ttttaaagtt gataactatc tctaaacccc ttgataaaca aaggagtttt catcattaac 2789161 cgatagaacc ttccatttcg aacttaatca aacggttcat ttcaactgcg tattccatcg 2789221 gaagctcttt tgtgaatggc tcgataaagc ccattacgat catttcagtt gcttcttctt 2789281 cagaaatacc gcggctcatc aagtagaaga gctgctcttc agatacttta gacactttcg 2789341 cttcgtgctc caatgaaatg ttatcattta agatttcatt gtaaggaatt gtgtcagaag 2789401 ttgatttgtt atccataatg agcgtatcac actcgatgtt agagcgggcg ccttccgctt 2789461 tgcgtccgaa gtggacgatt ccgcggtacg ttacttttcc gccctgtttt gaaatcgatt 2789521 ttgatacgat tgtagatgat gtgtttggtg caaggtgaat cattttcgca cctgcatcct 2789581 gatgctggcc tttacccgca agagcgatag aaagcgtcat accgcgcgcg ccttcgcctt 2789641 ttaggataca agccggatat ttcattgtca gcttagaacc gatgttgccg tcgatccatt 2789701 ccattgttgc gttttcttca cagactgtac gctttgttac aaggttgtaa acgttgttcg 2789761 cccagttttg gatcgttgta taacggcagt agccgccttt tttcacgatg atctcaacga 2789821 ccgcactgtg aagtgagttt gttgtgtaaa caggcgcagt acagccttca acataatgaa 2789881 cgcttgcttc ttcgtcaaca atgatcagtg tacgttcgaa ctgacccatg ttctcagagt 2789941 tgatacggaa gtaagcttgt agcggtgttt caaccttcac gcctttaggc acgtagatga 2790001 aagaaccgcc ggaccaaaca gctgagttaa gcgccgcaaa cttgttatca gtcggcggga 2790061 ttacttttgc ccagtgctca cggaaaatat cttcattctc tttcagcgcg ctgtcagtgt 2790121 ctttaaagac gatgccttgt gcttcaagat cttctttcat gttgtggtat acaacctcag 2790181 attcgtactg agcagaaaca cccgcaaggt atttttgttc agcttcagga ataccgagct 2790241 tgtcgaatgt ttgtttaatt tcttcaggaa cttcatccca agaacgctct gaacgctcag 2790301 acggttttac gtagtacgta atttcgtcaa agttcagtga gtttaaatct ccgccccatt 2790361 gaggcatcgg catattgtag aaatgctcaa gtgatttcaa gcggaagtca agcatccatt 2790421 gaggctcttc tttcatgcga gaaatttctt ctacgatttc ttttgtcaat ccgcgctctg 2790481 aacggaaaat ggaaacgtcc ttgtcgtgaa aaccatactt gtattcacca atatcaggca 2790541 tttttttagc catccatttt cactccaatc cttttaattg ccgccttctt ctttcgcgac 2790601 tcctttttca agtgctttcc atgacagggt tgcacatttg atacgggcag ggaattttga 2790661 aacgccttga agggcttcaa tatccccgag atctatagaa tcatcatact ctttcccttg 2790721 catcatatcc gagaaaatct tagacatgga aagggcagtt tcaatatctt tccctttaat 2790781 cgcctgagtc atcatcgaag cggatgccat tgaaatggaa cagccttccc cttcaaactt 2790841 cgcatcttcc acgatgtctc cgtcaagctt cattgtcagt ctgatgcggt cgccgcatgt 2790901 cggattgttc atatccacga caatgctgtc atttaaaacc cctttatttc gcgggttttt 2790961 gtaatgatcc ataatcacct gtctgtacaa tgtatctaag tttgcattaa aagacatttg 2791021 taaaatactc ctttgtcttt tgaagagctt ccacaagctt atcaatctct tcctctgtat 2791081 tatacagata aaagcttgct cttgcagtag cagttacatc cagccatttc atcagcggct 2791141 gcgcacaatg gtggccggct ctgactgcga ttccctccgc atcaagcaca gtcgccacat 2791201 cgtgcggatg aacatcatca aggttaaatg tgacaagccc ggcacgctct tccggcccgt 2791261 aaaccgttac gccgtcaagc tggcggaagc gttcaagcgc ataagctgca agcttgtgct 2791321 catggcggga aatctcatca agaccgattt cttcgagaaa atcaatggcg gcaccgaggc 2791381 cgattgctcc tgcaataatc ggcgtacccg cttcgaattt ccacggaagc tctttccaag 2791441 ttgattcata aagcccgaca aagtcgatca tttcaccgcc gaattcggca ggctccatgt 2791501 tttccagcag ggctttcttt ccgtacagca caccaacacc ggtaggtccg cacattttat 2791561 gggaagaaag cgcaaagaag tcgcaatcga gatcctgcac gtcaattttc atgtgaggcg 2791621 tgctttgtgc accgtccacc acaatgacag ccccattgtc atgagcgatt ttcgccattt 2791681 ctttaatcgg gttgaccgtg ccgagaacat tagatacatg agacaccgca acaatttttg 2791741 tgttgcttgt gaccgtttct ctgacgtctt ctaaagaaat cgttccgtct tcctgcaacg 2791801 gaatatattt taatgtggcg ccagttgctt ttacagcctg ctgccacgga atgatattcg 2791861 catgatgctc catgtaggtg atgaccactt catcaccagg tttcaggttg gcgcgcgcat 2791921 agcttaacgc caccatattc agtgatgtgg tcgtgccttt tgtgaaaata atctcagcca 2791981 ttgacttcgc gttaataaac ttgcggactt tttcacgcgc tccttcataa ccatctgtcg 2792041 ctctggttcc aagtgtatgg acgccccggt gaacattgga attgtattgg ttataatact 2792101 tatccagtgt ttcaatgaca gcacgcggct tctgggaagt cgccgcgctg tcgagataaa 2792161 cgagatcatg tccgttcact tgctgatgaa ggatcgggaa ctgttcacga atatctgtga 2792221 tattcattac ttcactttcc tttcgataac agaaactaat tgtttcttaa cgccttcaat 2792281 cggaagttca tttactaccg gtgcaaggaa tccgtaaatg actaagcgtt ctgcttcttc 2792341 tttcggaatt ccgcggctca tcaggtagta aagctgaata gggtccacac ggccgacaga 2792401 tgccgcatgt cctgcagtta catcgtcttc gtcaattaaa agaatagggt ttgcgtctcc 2792461 gcgtgctttt tcgctaagca tcagcacgcg tgattcttgc tccgcattcg ctttagaagc 2792521 gccatgttcg attttgccga ttccgttaaa gatagaagaa gcggaatcct tcatcacacc 2792581 gtgcttcaag atatagcctt cagaagcttt accgaaatgg atgatttgtg ttgtgaagtt 2792641 ttctgtttgc tctcctcttc cgacaacaac cgttttcgta tcgccgtatg tgccgtcacc 2792701 gtaaaggttt gttgtgtttt cggaaatcgt gtcgccatcg ttcatcaggc cgagagccca 2792761 ctcgattttg ctgtcgcgtc cgcgcgcagc accgcggcgg ttcacataag ttgtcacacc 2792821 gcttgacaga ttatccaccg caccgtatgt cacgctggca ttatcacctg tgatgacctc 2792881 actgataata ttgaagacag cgtctttcgg gtttacagtg ctgatgtagt tttctacata 2792941 tgttacagag ctgtggtctt cagccacaat cagcacgtgg ttgaatagag ctgtatcatt 2793001 gctttcgtgg acataaacag cctgaaccgg cgtctccacc tgaacatttt tcggaacata 2793061 aaggaatgct cctccgttaa caagagccgc gtgaagtgca gttaacttat gttcgtcaac 2793121 cttcacgccg tccttcataa agtatttctc caccaagtcg ctgtgctcgc gtgcagcagt 2793181 cagaatatca gtgaagatga cgcctttgtc tttcaattct tgagaaagag aaagatgtgc 2793241 cggcgtctgg tcacgctgta cgtataatgt tttatcttcg ttttcaatgt cgatcagcgc 2793301 ttttacttca tcagtcaaat cttctaatga agaaagcggt tcgttatcca ctgtatgctt 2793361 cgcgaaattc gtgaagttcc agtttgtgat ttttgttttg tcaggtttcg gcatcggcag 2793421 atcctcagct tgttcaagag cctgtaagcg caggttcttc agccaggcag gttcttggtg 2793481 cttttcggaa aagcttttga gatactcctg atctacggat agttttgtac ctagtgtcat 2793541 attaatcccc ctaacgctta cgcttcttgg ccaacagttt cgtcttcaat gccaagttct 2793601 tgtttgatcc agtcataacc ttctgcttca agacgctgtg caagctctgc accgccggat 2793661 tttacaacgc ggccttgcat cataacgtga acaacatccg gagtgatgta gtttaacagg 2793721 cgctgatagt gagtgatcat caggcagccg aagttttcgc tgcgcatttt gttgatccct 2793781 tttgatacaa ctttcaaagc gtcaatatca aggcctgagt caatttcatc aaggatggcg 2793841 attttcggtt caatcatcat taattgaagg atttcgttgc gttttttctc cccgcctgag 2793901 aagccttcgt taagatagcg ctgagccatt tcagggtcca tttcaaggaa ctccatgttt 2793961 tcgtccattt tgcggatgaa tttcatgaga gaaatttcat cgccttcttc tctgcgcgcg 2794021 ttgattgctg agcgaaggaa gtcggcattt gtcacaccgc tgatttcact tgggtactgc 2794081 attgcaagga ataagcctgc ctgcgcacgc tcgtccactt ccatctccag tacatctttg 2794141 ccgtcaagcg tgatgctgcc ttttgttact tcatatttag gatgccccat aatagcagct 2794201 gataaagtgg atttaccagt tccgttcggg cccattactg cgtggaattc tccacctttt 2794261 atttcaaggt ttacaccctt taagatctct ttcccttcga tttcaacgtg aagatctttg 2794321 atcgttaatg ttgaagcagc catatctata cctccaaaaa tatataatca ttattctcat 2794381 tttattctca ttctaatttt ataacaaatg aaaagtaaat acaacttttt atcgtgcctt 2794441 gcacattcct caagtttaac aaagatcagc actttattaa agcgattgaa aaagaaaaag 2794501 agtggattcc cacccttttt taaaagattg attttctcaa taagctcccg cagaaatccg 2794561 cttgcttttt tcataatcaa gctctctctg ccgctctact ttcattcttg tttccagccg 2794621 gcgtccatat tcctcgtatc caattccgtg tgacagctgc atcgcttttt ccatttctga 2794681 cgtataatcg aggttcagtc tgtcctggct gctgcaaata atgaatcaat cccttcatat 2794741 atttgctttt tattgtacca gtgctgcgtt ggatgccgca aaaacgattt ggcgtgaaat 2794801 agcggcagat gagacgaaag catcctttca gaacaaatga gaatggtttt tcggaatatt 2794861 ccttctctta atgcgtggtg tttccgaatt cctcaatgca ctgttgaacg actgtcacgc 2794921 cttggctgaa agctgcgccg cctccaaatg ccgctgccac actgacggct tcgagaatgt 2794981 tttcttctga cgctccctga tcaagacagc cttttgtatg atagatcatg caatattcgt 2795041 cctgagcatt gatggcaatt ccgagggcga tcagctgttt ttctctttca gtcagagaat 2795101 tcccggcaaa gcactgttca gtaaattcgt taaattttct tcccatcagc ggcatctttt 2795161 gttcaaatgt gcctaaacca tgtttatatt gttttaacgc gtcctgcatg cttcctctgt 2795221 cttgattcaa agaaaatccc tccatctgtt taacattcct ttttattatg aacagctttt 2795281 aggaaaatac gcgaaaaaaa ccccggaatt ctcatccggg gtttcagtct tattcagata 2795341 caggaagcac agctccgtcg tattttttct cgatgaagtc tttgatcttt ttagagtgaa 2795401 gaacttccat cagcgctttg atttttgcag aatcttcttc gccttttctt actgcgatga 2795461 tgttagcgta tgggttgttt ttcgttgatt ctacttcaat tgcgtctttt ttaggattta 2795521 atttattttg gatcgcatag tttacattga tgaagaccgc gtctccttct ttgttttcat 2795581 atgcttttgc cgttaattca ggcgctactt ttttgaattc aaggtttttc gggtttttct 2795641 taatgtcttt caatgttgcg tcaactgttt ccactttaga atcaagagtg attaatccag 2795701 cgttttcaag cattgcaagc atacggcctt gttcagcaac gttgtttgtc agaatgattg 2795761 tcgcaccgtc tggaaggtct ttcagtgatt tgtatgtttt agagtaaata ccgaatggct 2795821 ctaagtgaac agcgccggca ttcacaagtt tgtaatctgt gttttctttc atttcttgct 2795881 caaggtaagg aatgtgctgg aagtagttcg cgtccacttc tttatcagct aaagctttat 2795941 tgtacatttt gtaatcacta agcactttca ctttcagcgt atagcctttt tctttcagca 2796001 atggttcagc ttcttttaaa atttccgcat gcggtgtttt tgttgccgca acgacaattt 2796061 ctttcttgcc ggattcagcg ccgttattcg aaccgcaggc agccataact cctgcaaata 2796121 caagcagtaa tgcacccaaa aatagctttt tcaatgtaaa tcctccctta tcgtttgtct 2796181 ataatatttg ttattagatc accgatgatt tgaataataa acacgatgat taaaataaac 2796241 acagtagcaa cgaaggtaac atcagcgtta ttagactgat atccttctac gtacgcaagg 2796301 tttccaaggc ctcctgaacc aatggctccg gcaattgccg ttgaaccgat taaagcgatg 2796361 gctgtaaccg taatgccaga aataagagca ggcattgatt ccggaatcag cactttgaaa 2796421 ataatcgtag acgttttcgc gcccattgat ttagctgctt caatcacacc tttatccacc 2796481 tcacgcagcg cgatttcaac aaggcgcgcg taaaatggtg ccgagccgat taccagcgcc 2796541 ggcaatgcgg cgtttggccc taagatcgtg ccgactaaaa atttcgtaaa acctaatagt 2796601 aaaataatta aaataaggaa cggaatcgat ctgaatatgt taacaacggc tgcaatcact 2796661 gagttgaccg ctttattctg ccagaggctt cctttgctcg tcagaaagag cagcaagccg 2796721 aggatgaccc cgatgacaaa agcaaacagt aaagaaatca gcgtcatata aagtgtttca 2796781 tatgtcgcgt tccataattc agttaaatca acgttcggga agtatttttc aaacattcgt 2796841 gatcacctct gctttcacct gtttgtcatt aatgaatcgg atcacgtttt gcacttcttc 2796901 ctcgtccccg tcaatgtgga tgaacagtga accgtaagcc ccatccttcg tctgcgaaat 2796961 tttcccttgc agaatattga cgctgacatt gaagtttctg atcatctctg taatcagagg 2797021 ctgttcagct gactcaccga caaatgtgag ctgaaccatt tttcctgatg ctgtatcatc 2797081 aagaaggtgc tgaagcgtct ctttcgtttc ttccggctct gtcacctgtt gaacaaatcg 2797141 ttttgtcatt tgttcctttg gatttttgaa gacatcgaga acctcgcctt cttcgaccac 2797201 cttgccgttt tccatgacgg cgactctgtt gcagattttg cgtatgacat gcatttcgtg 2797261 cgtaatcagc acaatcgtca aaccgagtct ttcattaata tcggacaata gatccagaat 2797321 tgaatctgtc gtttgcggat ctaatgctga tgtcgcttcg tcacaaagaa gaaccttcgg 2797381 attgtttgca agcgctctgg caattccgac acgctgcttc tgaccgccgc tcagctggga 2797441 cggataagat ttttcttttc cttctaaacc taccagttta atcagttcat tggcgcgctt 2797501 gatccgctcg ctctttttca ccccggcaat ttctaaagga aacatgatat tatctctgac 2797561 agtccgcgac caaagcaaat tgaaatgctg gaaaatcata ctgatctcat ggcgtgcttt 2797621 tcttaaaccg cgtccattta cttcattaat cttggttccc gccacttcca cggttcctga 2797681 ggttggtttc tcaaggccgt tcagcagacg gattaaggaa ctcttaccag ctccgctata 2797741 tcctataatt ccaaaaatct cacctttttt aatggaaagc gagacgtttt ggacagcatt 2797801 gacatctcca tgtttcgact tgtaaacttt tgaaacatcc tgaagattga tcaaagcaat 2797861 cacctgcctt aacactattc taagaaatct tccggttttt tctgcaaaag aaaagccttt 2797921 ctgcacactt gagcagaaag gcttatataa aatgcctttc tctcatcttt caaagctgaa 2797981 cgcttcgtgt gaattggcac catttcaaca gtgttgatgg ttgccgggct tcatagggca 2798041 cttccctcca cctctcttga taagagaaat atatagtctt tttcgtccgg aaattcttaa 2798101 tgtagaatag cacggcgaat gattaaatgt caataaaata aatgatgtca acttttacta 2798161 ttataataat ttattatttt ttaatttttt aaaatcctct gaaaaaatcc atttgtcagc 2798221 cagagaatgg cttccagctt taacagggcc ctgaatgacc cctttacttt gaggcttccg 2798281 ctctgaataa ggtgctgaag ggaaatgtct ccgtgcaata aatcaataat ttccgtttgg 2798341 tttccgtaaa aggtcaggtt ggacgtttgg ggcggagaaa cttttttcat ttctccctgt 2798401 tcgtttattg agacggttaa ggcttctgct tctccttgga aggtaatgag caatgttgag 2798461 gcattcaaaa ggggttttaa aaacagatgc tgatactcat cttctaaaac ttccgctttc 2798521 tccatatgta caacctccta tttgttggtc atacatacac atttctctct ttgtcgcaag 2798581 aaccccttta taaaacgaac gacaatttca ttggatatgc tgagaaatat gtcataaatg 2798641 ggatgcggaa gatgattttt gtttgatcag ctcatataaa taagaaacgg aatgaaatgc 2798701 atatcctctt tcgaccatct ttccgccttt aaacagcaga aaacaaggga cgctttcaat 2798761 ttgatacgct tttgcgaatg tcggagagta attgacattg ttttgataga aggcgacatc 2798821 cggcagcatt tctttcacca ctgtcagcat tttgcttgca agctggcagg tgccgcaaaa 2798881 cggagtatat aaatatagaa ggtacacatc atcttcaatg tgatcaagtt cgtgttcttg 2798941 gagttctttc atgctataca cctcgggact ttctttcaag aaaaatagta tggacattca 2799001 gattcgcacg cagcaataca gaagcgatat ggtgcctggg cgcagccgct acttccttat 2799061 aggctctgtc gacatggaga tggcaggctt cattaaattc acgcttcagc tgttttctca 2799121 atttctcacc tgattcatca gcatcaacta atatatagac gtctttatca taaagctcgt 2799181 cagccaattc ctcgagcctc agctggctga ttgttccgtt tgtgcagata atgcgcatcg 2799241 gttcattcag gacgctttcg attttctctt tatctgattt cccctcgaca atcataacct 2799301 tttccagctc atccatcttc atcttgttca cctgccgcgt caaatttgaa atgttcagat 2799361 tgtaaaagaa ggcagtgaaa ttcaccgcca acattaacac cagccgtttt cgtagtcaca 2799421 atctacatat tttgcgtcgt ctccagagac cacatcggct gtcttataaa atttctcatt 2799481 ttcaaaggaa taaccggact taagctcata ttcattcatg cttgtcattt ggccgatcat 2799541 ctcattatca tgatataacg agagccggcc attttgaaag cggcctgtca cgtcattggt 2799601 gacatcgagc ttttgtttgt cgaaagccat attggacacc tcccataacg ttagcgtgtc 2799661 caattgcttt tacggctatc ctgttttagt cttcttgtgt catctcttcg tattgctctg 2799721 ctgtcatcag tttttcaatt tcagaagcgt cagatggctc aacgacgatc atccatgctt 2799781 tttcgtacgg agattcgttg acgaattccg gactgtcatc aagatcttcg tttacttcca 2799841 caaccgttcc gttaatcggt gcataaagct cagataccgt tttaacggat tcaacactgc 2799901 cgaatggctc gtccgctttg atttcagcgc ccacttcagg aagttcgaca aacacgatgt 2799961 cgcctagttc ggactgggca aaatgcgtaa ttccgattct ggctttttct ccttcaactt 2800021 ttacccactc gtgttctcct gagtaacgca aatcttttgg tatgctcaat tgaatccctc 2800081 cattttttac agcactacaa taagaagata ccacactttt caaaaaaaat ttacattaag 2800141 cccagttttc ttcaaattgg tcttctttaa atccgacagt cactttttcg ccgtctgttg 2800201 taagcgggcg tttaattagc ataccatctg aagccagcag ttcgagctgt tcgtcctctg 2800261 acatatgata cagcttttcc ttgagattga gctcgcggta tttcatgccg ctcgtgttga 2800321 aaaatttctt gagatccagc ccgctttttt cataaagcgc ttttaattct tctttgcttg 2800381 gcggctgctc agcaatatgt atttcgttta tttctttccc atgctcttca agccacttct 2800441 ttgctttgcg gcacgttccg catttagggt accagtaaaa agttaacgac atcttcttcc 2800501 ccctcaataa aataatcgag gttattttaa cacagtttgt tttaaaaacc taaaacagtg 2800561 cttcttaaaa aagagctccg cgcatgcgga gctcatggcc aatcagacag tatatttctc 2800621 agcctcaaaa atgcctgccg ccgcctcgcg ttttttctga atcacgtttt taggcgttac 2800681 gcgtgtcagc ttgcgcagag cggaaagcat catgcggagt gaatctcctt cttccattgc 2800741 gataagggat tcctttgcat gcgcttcgat ttcgttaaag gcctcttgaa cgaaaatttc 2800801 tgtgtacagc accttttgcg ctgctttttc agcgccttgt gcggcaatgg ccttttccgt 2800861 tctgagcacg gctgattcca ttgcgtatac attgctgacg atatccgcta cgttcacgag 2800921 aatttcttgc tcacgatcga tcgcttttcc gtatttttgc gcggctaggc cggcagcaaa 2800981 caacgcaatt tttttggctt gcttgacgat atatttctcc tgctctaaga cgccgcttcc 2801041 aggctcttca ggcataagca tcatgagttc ttcctgcagc gactgcgctt tttcgaataa 2801101 aggcagctcg cctttaagcg cttttttcag gaaggtgctt ggcacgatta accggttgat 2801161 ttcgtttgtg ccttcaaaaa tccgattgat ccttgaatcc ctataggccc tttctacttc 2801221 gtattcctgc ataaagccgt agcctccatg aatctgcacg ccttcatcaa cgatataatc 2801281 aagcgtttca gagccgaata ccttattcag agagcattcg atggcgtatt ccgcaatcga 2801341 tttggcgatt tgccggccgt ccttgagatc ttcggccgtg aactggctca tattgtcttc 2801401 aaacagcccg acggttctgt atacagagct ttccatcgca tacagccttg aggccattgt 2801461 cccgattttt tcctgtgtca atgaaaaacc agcaatcggc gttttaaatt ggcggcgctg 2801521 atttgcgtat gccgcagaca gctcgatgac gcgtttagat gcgccgattg tgccaaccgc 2801581 cagtttgtaa cggccgatgt ttaaaatatt aaaggcgatg acatgccctt tgccgatttc 2801641 tccgagcagg ttttcctttg gcacttcagc ttgatccaga atgagggttc ttgtcgatga 2801701 tcccttgatt cccattttct tttcttccgg tcccgtggag acacccggga actctttttc 2801761 tacaataaag gctgaaaact tgtcgccgtc taccttagcg taaactacaa atacatcggc 2801821 aaaagcagag ttggtaatcc actgtttttc ccctgttaat acataatggg ttcctgcttc 2801881 attcagcaca gctgttgttt ttgctccaag tgcatcagac ccagagccag gctcagtcag 2801941 agcataagcg gcgatctttt cgcctgaagc gagtccaggc aaatattttt tcttttgttc 2802001 ttctgacccg aaaaagacga tcggcaagga accgataccg acatgcgcgc cataagaaag 2802061 agaaaagctt cccgcacgcg aaaatttctc agtgatgagt gccgagctga ttttatcaag 2802121 gccgagcccg ccgtattctt ccggcacatc ggcgccaagc agccctagtt cgcccgcttt 2802181 cttcaacagt ctgacagaat gctcgaattg atggttttcg atatcatcta tatgagggag 2802241 aacatcttgc tcgatgtaat cctctgttgt tttcgcaatc attttatgct cgtcagtgaa 2802301 atcctccggt gtatacattt gatcgtatgt gacatcctcg attaaaaatc cgccgccttt 2802361 ttgtacgtca gccgcttttt ttgccatttg tttttccccc tttagcataa ttcaaataca 2802421 ccggccgctc ccattccgcc gccgatacac atggtcacga ctccaaattg ctcgtttctc 2802481 cgtttcattt catggatgag tgagagtgta agctttgtgc ccgtacagcc aagcgggtgt 2802541 ccaagcgcga ttgcgccccc gttgacattc actttttctt catcaattcc caattccctg 2802601 attacttgaa tggcctgtga ggcaaaagct tcattcagtt caaacaagcc gatgtcctgc 2802661 agctgaagtc cggcaagctt caaagcgcgc ggaatcgctt ccaccggtcc gattcccatc 2802721 acttccggcg gcacgccgcc taccgcaaag gagcggaatt tcacaagcgg cgccaggcca 2802781 agagcatcgg ctttttcccg gtccatcagc atgacagccg ccgctccgtc actcgtttgt 2802841 gaggaattgc ccgcagtcac cgtcccgtca acggaaaagg ccgggcgcaa tgtcgataag 2802901 atgtctgcag tcgtttgcgg gcgaacacct tcatcctgag aaaacacaaa ctgtttttcc 2802961 ataggcttat ggtcttctcc gatttctgtc accgtcactt cgacgggtac aatttcatct 2803021 ttaaattttc cttctgcaag ggctttagcg gcgttttgat ggctgcgaac ggcaaacgcg 2803081 tcttgatcct cacgggagac gccgtatttt ttcgcgactt gctcggctgt gtgccccatg 2803141 ctcatataat attccggtgc cttttctgcc aaagcaaggt tcggacgggt aacatgcccc 2803201 atcatcggaa cttgcgacat ggattctgct ccgccggcga tcgctgtatc gtaggcgccc 2803261 agcataattt tttctgctgc atacgcaata gactgaaggc ctgaagagca atagcggtta 2803321 actgtaatcg ccggaaccgt gtacggcagg cccgcgagcg caccgatatt tctcgccata 2803381 ttaagcccct gctccgcttc aggtgttgca cagccgataa tcaagtcatc aatattgcct 2803441 tcgtagccgc ctgcccgttt cagcgtttct tttacacaaa tcgctcccaa atcatccggg 2803501 cgaacggtgg ccaacgatcc tttttttgct tttccaaccg gtgttcttgc acctgacaca 2803561 atgactgcct ctttcataag ctccctccta attccgtaaa ggtttacctt tcacaagcat 2803621 atgctgcatt ctcgcttgag attttgcctc tcctgacaaa ctcaaaaacg cttctctttc 2803681 gatctccaat aaatactctt catcaacctc tgtaccaaac ggcacttttc cgcccgcaat 2803741 gacataagcg agttttttcg cgatcttaaa atcatgctca gatatatagc cggacagctt 2803801 catctgctca gcgccaagca agagtgccgc ataaccggtt tctcccggca ccttgacctt 2803861 ttcttttaca ggcggccgcc agccggtatc gtataaagat gcggccagct gcttcgcatc 2803921 gtataacagg tggtcttgat tcacgctgat ctgatccgtt tcttttaaga tgttcatctc 2803981 acgagcctct tgagcggaag cggacacttt cgccatcgcg attgtttcaa atgttttcat 2804041 tgccgcattc atcggatcat ggccgcggcg aagatggttg atgtacagct ctttgttacc 2804101 tcctccgcca gggatgaggc cgacaccgga ttccacaagt cccatatagg cttcgcttgc 2804161 cgcttgaatg cgcgccgccg gcaggcatgc ttccgttcct ccgccgagcg tcatgccaaa 2804221 tggcgcggcg acgaccggtt tcgcactgta tttgatcttc atcatcgtct cctgaaaacg 2804281 gcggatcaca aaatcaactt ccaaaaagtt gtcatcttgg acttccatta agatcatggc 2804341 gagattcgcg ccgacgcaga aatttttccc ttgattgccg atgacaagcc ccttgtaatt 2804401 ccgttctgtt tcctctaatc ctttgtggat catttgaatg atatcgaggc cgatcgcatt 2804461 gcttttcgaa tgaaattcaa gaagggccac atcatctcca aggtcaatta agcttgctcc 2804521 gctgtttttc gcaatcacgc cttttgtttc tttaagtgct tgtaaatgaa ttcgtttttt 2804581 gttttctttc acggctctgt attcgccgcg gtcataataa aataccgttc cgttctcttt 2804641 gatgtagaag gtttcatttc ctttgtccag catctctttt atccagccag gcatatctgc 2804701 tccaagctgc tcaagctttt ccgctgactg cttgaggccg atggcgtccc acatctcaaa 2804761 aggtcccagt tcccagccga atccccactt catggcttgg tcaatcgcat gaatatcatc 2804821 ggcaatctcg ccaagcagct cggctgagta aagcagggtt tgagaagtga tattccacag 2804881 caaacggccg gccctgtcat ccgaataaat aagcgctttc attttggctt ttgtcccttt 2804941 tgcctgtttt gccgcttcaa gtgccggtga tttcattttt gtccgctcgc cgtaagtaag 2805001 cgtcactggg tcaagctcat aaatcgtttt tccttctttt ttataaaagc cttggccggc 2805061 cttgcttccg atccaccctt tttccagcat atcgttcatg aagcttggaa tgcgaaacac 2805121 ttctttttca tcgccatcag ctttgtcata cacatttcgg gcaacgtggg cgaatgtatc 2805181 gaggccgacc acatcaagcg ttctaaaggt ggcgcttttc ggcctgccga tcagcggtcc 2805241 tgtgatcgaa tcaacctccc cgacctgata accgcctttc agcatttctt ggactgtcac 2805301 gagaagcccg taagtcccga tgcggtttgc gataaagttc ggtgtgtcct ttgctgtaac 2805361 aacgcctttc ccgaggacat tttctccgaa agctgtcata aactttaaaa tatcaggatc 2805421 cgtttcctta atcggaatga tctctagcag ctttaaatat cgtgcgggat taaaaaaatg 2805481 cgttccaaga aaatgggctt taaaatcatc cgaccggcct tcagccattt cctgcactga 2805541 tatgccggat gtgttgcttg agacgatgct tccagtcttt cgatgttcat ccacaagagc 2805601 gaaaattttc tttttgactt caaggttttc gacaacgacc tcaataatcc aatctgcttc 2805661 tttcagtttt tctgcatcat cctccagatt gccaggtgta atataggagg tatttttcgc 2805721 tgatgtgagg ggagcgggct tttgtttcag cagttttttc atcgcctgcc ggctcagcct 2805781 gctgcgcacc tccgaactgt ccttcgtcag cccctttttt tcctcttcct ttgtcaaatc 2805841 gttcggcaca atatctagca gcaggacagg aattccgatg ttagccaaat gcgccgctat 2805901 cccggaaccc attacccccg atcctaaaac ggctgccttc cgaatgtgtt tgtgcatgag 2805961 atatccccct tgaacattga atgaatagtc attcattttt tgactaaaaa aaatgaaacc 2806021 cgtttcttct ttcatcttaa aagatttccg gttcgacttc aatagctaat ttgttatttt 2806081 tttgtatgaa gcctataaaa gtcgggcaac ttaagcccgg aggtgaaggg aatggtacga 2806141 gagaaaaaaa atccgtcttc agcggcagtc agcgcggcga gcgtaaaggg agatgccggt 2806201 ccgactcagc attacggcgg cggaaaacgg acaagtcaaa atcagcagta taaaaaacat 2806261 aacatgggac aatcataatg cagctgcttc ccacggctgc tttcactttt tcaaaattcc 2806321 ttttaacaca aacgctgcat tggcaggccg ttcggcaatt cttctcataa agtagctgaa 2806381 ccagtccgtt ccatatggga catacacacg cattctgtag ccttccttgg cgagttcctt 2806441 ctgacgctcc ggcctgatgc cgtatagcat ttgaaactca aattgcgatg cggggatttg 2806501 atgttcggcg acgagctgtt tcgtaaatgc aatgatgtca tcgtcatgtg tggcgacagc 2806561 cgtgtagttc ccgcttaaca actgcagctt tattaagctc tgaaaatgaa ggtccgtgcc 2806621 tcttttgtcg ggaaacgcta cagccgcaga ttctttataa gcgcctttta caagtctgag 2806681 attcggcttt aagtcccgca tctttctgat atcttctgcc gcccggtaca aatacgcctg 2806741 aatgaccgtg ccgagcttct caaattcctg tttgcattgc ctgtaaatag aaagtgtctg 2806801 ttcataatga gaatagtctt ccatatcaat ggtcacagca acatcatatt gcttcgcaac 2806861 ggaaagaatg gcgcgcaaat gagtaagagc aagttcttct gaaagatcga gcccgattga 2806921 ggtcagctta agtgaaagct ctgaattcaa ttgatgttcg gcaatggctt gaatggcttt 2806981 cttgcattcc tctgcgactt ggtttgcttc tttttccgaa gctgcatact cgcctaaata 2807041 atcaattgtt gcacacaaac cggatctgtt tagccttttg acggtcttaa ccgccgattc 2807101 aatcgtatcc cctgcgacaa accttcgtgc tccaagccgc gttccgtatg cttttgcgaa 2807161 cttggtaagt gttttatttt gagataagaa taaaaacaca tgtctcaaca tccgactccc 2807221 tcccgccgtc atcttcaaaa cacctgtata taactcccag tctgaaggaa actataaaat 2807281 gaacagaaac caaaggagga tcacaatgga taatcagcag caatctcaaa tgccgccttc 2807341 cgttatttcg acaaaggatc atttgtatct caatgacatg ctgaactgga atttgctcgc 2807401 gatgaaaaaa gcgcatttca tggcgcagca gtgccaggat caaacgttaa agcaagaact 2807461 cgaccgcgtc ggacacatgc atcatgatca ctatcaaaga atattaaagc acctgcagcc 2807521 aggccagcag cagtccggct acatccaata aggaggcgcc agaatgaatc agcaaaatca 2807581 aaaaatcagc aacccgcaga cacctgtacc gacaacatcg gaaatgaatg acagagattt 2807641 cgtcaacgaa ttgctgacaa ccgaaaaata catgacaaca gcttattgca ctgccttgca 2807701 cgaattcagc cacgagtctc tttatcagga tattcaatcc atttttgatg agtcacaaaa 2807761 agcgcaaaga aaactatatg atctcatgtt ccaatatgga tggtattctg ttgaagcgga 2807821 ggattcacaa aagctgcagc agtcctatca aaaattccag cagaccattc agcagcagtc 2807881 tccttatcag caataacaac attagtaaaa aggatacgat gttctttcgg gcatctatcc 2807941 tttttttgtg taaaatcagt tgacttttca tttacgctta tttatattta ataagcatta 2808001 actattttgt cattaaaata tatatacagt gtatgtaaca gaggggaaat gaatatgaag 2808061 agtgcggatc agttaatgtc cgatattcaa ttatcgcttc aggcgctctt tcaaaagata 2808121 cagcctgaaa tgctggaaag catggagaaa caaggtgtca ccccagcgca gctgtttgtg 2808181 ctggccagcc taaagaaaca cggcagcctc aaagtttctg aaattgccga gcgtatggag 2808241 gtgaagccaa gcgcggtgac gctgatggca gatcgccttg aacaaaaaaa tcttatcgcc 2808301 agaacacaca acacaaaaga caggcgagtg attgatctca gtcttactga cgaaggagac 2808361 ataaagttcg aggaggtttt ggcgggcaga aaagccataa tggcgcgcta tctttccttt 2808421 ttgacggagg aggaaatgct gcaggcggcg catattacag caaaactcgc acaagcagca 2808481 gaaacggatg aaaagcaaaa catgaaaaga ggaaacggat gaaaatgagt aaagaaggca 2808541 aacaatcaaa acgaacgtta ttaataacag gcttaattat tgccatgttt ttttcagccc 2808601 ttgacggtac cattgtcgga acggccatgc cgaaaattgt cggtgatctg ggcggtttga 2808661 gcatgatgac ctggctgaca actgcatatt tgttaacatc aacaaccatt gttccaattg 2808721 ccggtaaact ggctgattta ttgggacgcc gcattgtcta tgtatcaggt ttgattattt 2808781 ttatggccgc ttctgctttg tgcggaatgg ccaacaacat gacggaattg attatcttcc 2808841 gtggactgca gggcatcggc ggaggcatca tgatgccgat ggcgatgatt gtcatcggtg 2808901 acttgttcac aggaaaacag cgtgctaaat tccaaggtgt ctttggcgca atttacgggc 2808961 tggcttcagt gattgggccg caaatcggcg gctggattgt agactcgtta aactggaaat 2809021 gggttttcta tattaacctg ccagtcggaa ttattgcggt tatttttatt gccaggggat 2809081 tacagggacg ccagcagact ggtccgatca acttcgatat cgctggtatt ttcacaatga 2809141 ttgtcggtgt ggtcagcctc ctgctcgcct taagctttgg cggaaaagat tatgcatggg 2809201 attcatggca gattcttggg ttgttcgctc tcgcactgat cggcattgtc agctttatca 2809261 tcgtagaatc aaaagcaaaa gagccaatcc tgccaatgta tttatttaaa aacagaacat 2809321 ttacatttct aaacttgatc ggcttcttta tgagtatcgg tatgtttggc gccattacgt 2809381 ttgttccttt ctttatgcag ggaattgtcg gtgtaagtgc gtctgaatcg ggtacaatta 2809441 tgacaccgat gatgatttct atgattatca caagtatcat cggcggacag cttgtttata 2809501 aaattgggat taaaccgcaa atcattacag gcatgctggt tatggccggc ggattcctgc 2809561 tgttaacgac attggatctc gacacgagca agcttgtcgc tacatctttt atggcgatta 2809621 ttggtctggg aatgggtctt gttatgccga ttctgacatt ggctttacag gaaagctttt 2809681 cgaaggagga gcttggagtt gtcacttcat ccagccaatt cttccgttct atcggcggaa 2809741 cattcggcat taccatgctg ggagccgtaa tgaatgcgag atcaggaaat ctattaacag 2809801 ataaattggt tccatattta gactctcttc cggcacaggc aagctcgttt gccgcccagc 2809861 taaagggtat gattgataca aatccgcaag ggctgctgca atcactgttc agtccggacg 2809921 cggtcaaaca aatccctgcg gctttctcat cccatattgt gccgatttta aaaacatcgt 2809981 tgatggattc gctccacagc gtgttttata cgggcctgat ctttatcgca gtcggagccg 2810041 tattcacctt gttcttaaaa cctatcaagc tatcaaataa gaaagcggaa gaccaacaag 2810101 aaaaagagaa ggcggcaaaa gccgttgaat caccttccca ttaatagagc accccgcggg 2810161 tatcaatccg cggggttttt tattcaatca tctgggctct tccatttccg aaagaccaat 2810221 cctcatcctg atttccggcc agcatgataa acacatcttc ttttcttaca ccaagctcgg 2810281 aatgaatccg gctcgcgatt gagcggtaaa gtgctttttt ctgttcagtt gttcttgact 2810341 gtttcagtgt aaaatgaatg tatatcagtt catcagtacg ctcgacttgg agataaaatg 2810401 gatcataaaa aaattcgctt ttttcatatt gtctgatgac ttggaaatag tcatcttccg 2810461 gcacattgat ttcttcaatc atcgattggt ggatagtcct gctcagtttt tgaagccaca 2810521 cttcgcttct tcccgaccgt aaatgaatct gtacaaatgg catctccccg catccctttc 2810581 tttacagcgt ctgtccgctg tcaattgtga taatttggcc tgtgagtgat tcctgttcaa 2810641 ttagtgaaca aatcaatttg gcaacatcat ctggttcagc aatacactgc agcagcaaag 2810701 agccgatcat gcttttcatt ttttcttccc gtccggccca ccatctcgtt gccacagctc 2810761 ctggtgctac accgctcact ctgatttcag gcgctaaggc gtgggccaat gatttcgtta 2810821 aaccgtgcac cgctgatttt gatactgcgt aaggcattga tgagccggca ccagttatcc 2810881 ctgcgatgct gccgacgttt acgatcgccc cgtccttgct tttcttcatg aacggaacca 2810941 ctgcccgcgc gcagaaaaac atccctttca cattgacggc atacagctca tcctagacgt 2811001 cttctgtcgc agcctcaaga tcatccattg gaatatgccg tgtaatgctg gcattgttga 2811061 ctaaaatatc aaccgtgccg tgtgtgttca cgattgcttg aatcatatcc tgcacgtcgc 2811121 tgtttttgga tacatctgct tggatggcga aggcttgccc gccagctttt tgaatcattt 2811181 ccactgtttc ctccgcttct gattgcgagc gtgaataatt caccgccaca atcgccccac 2811241 gctttgccaa ttccatactg gctgcttttc cgattcctgt gccgcccccc gttacgagag 2811301 ctattttgtt caagacattc attgccgcca ctccttgctg ttgactaaag tatatttctg 2811361 attccattgt aatccagctt tgatgttacg tataatgatt gttaaagata ctagatatca 2811421 ctcagattga tagtaaacga acggaggagt tcaaaatgga aagcggagat ttacgtgtgt 2811481 ttcaaatggt agctcgtgaa gggaccatta cgaaagcagc cctgcagctt ggctatgtac 2811541 aatcgaatgt cacggccaga attcaacaat tggaagctga gctgggtacc acactgtttt 2811601 tgcgccataa tcggggcatg acactttctg caagcggaaa attgctgctg gactacgcaa 2811661 ataaaattat aggccttctt gatgaagcgt ctaaagcgct ctcatcctcc gcagaaccaa 2811721 gcgggccgct tatgatcggc tgcactcaga caaccgccgc ggtaaggctt ccaaagcttc 2811781 tggcatctta ttatgaagaa catccaaacg tccagctgtc tttaacaaca ggacatacgc 2811841 aatttctcct tgataaagtt cttcgttatg aattggatgg cgcgtttatc ggatgcgaat 2811901 gccatcatcc tgagctcgaa tcctatcctg cgtttgagga agaaccagta gttgtttcgg 2811961 ctgcctccgt gcccgatgtt gaggaagcca tcacaaagcc gattctcgtt tacagcacag 2812021 gctgttcgta tcgagaaaca cttgaaaaat ggctgcgttc cgtcggtgtc acacagccgg 2812081 tcattatgga atttgggacg cttgaagcaa ttatcggcgg ggttacagca ggtcttggca 2812141 tctcgttgct gccaagaacg gttgtgcaga aacatgaagc agaaggatca attcgattgt 2812201 acccgctgcc tgaagctctc agccagatga aaacagagtt tattgttcga aaagattcgt 2812261 ttatcagcag cgcgctgaga acctttatgg attcctttac gccagttaaa acggctgaat 2812321 cacaaaaaag cagtctgcta taatgaacag actgcttttt ggctattgtt tgtttcgatg 2812381 cgcttcattt aattccttaa tatgctgaat gatctcttta atgccctgct tcgcgtcggg 2812441 gtatgtcgca ttccaatgct tagcgagcgg aggcatgctt ttggctatat gggtgtacaa 2812501 aatccattgc ttcacttctt cttttagctc atcgtttgtt tcaccaagca gaagctcagt 2812561 atacttctcc agcaatccat caagctgctc ctgaagtttt tgttccattt tccatcttcc 2812621 tttcgaaaaa acagcaagga gctttctcaa ttgaaagctc cttcgctgcg ttatttatcc 2812681 atgtgatgtg aaagccgctt cctggacaat gcatctgccc ctgccatgag gaatgcaaag 2812741 aggcgttccg aagagcgggt cctgtgtaac ctgacagttc atagaaaaca cattttgcac 2812801 aagatcacaa gtgatgacct cttccggacg gccttctgca taaatccgtt tatcttttat 2812861 ggccacaaga tgatgcgcat agcggcacgc caagtttaag tcatggagaa ccataacaat 2812921 cgtccggtct tccttttcat tcagctcaaa cagcaaatca agaatttcaa tttgatgcgt 2812981 catgtctaaa tacgtcgtcg gctcgtcaag aaggatgata tccgtttcct gggcaagcgt 2813041 catcgcgatc caagcccgct ggcgctgtcc gcctgacaaa gaatcaacgg cacggtcagc 2813101 catgtcctca agctttgttg ctttaagcgc tctttcaact gcttcctcat cctcttttga 2813161 ccactgcttc agccagtttt ggtaaggata tcttccttgc ttcaccagct gatgcaccgt 2813221 cagcccctct ggagccgaag gaccttgggg caggattgcg agctcttttg cgacttcctt 2813281 cgtcggaagc ttggcaatcg ctcttccttc cagcagcact gaaccgcctc tcggcttcat 2813341 caggcgcgct aatgaacgta aaagtgtcga ttttccgcag ccattgctgc caataaatac 2813401 ggtaatttca cctttgggaa ttgttaaatt caactcatca ataataacgg catccccgta 2813461 tcctaagctc agcgtttctg tagaaattgc actcataccc ataaccgctc ctttttgctg 2813521 gctttttagc agcactatgt attgcacgtt ttctatatac atgcttttaa gtcaattgtc 2813581 atcaatgcaa atgattccga tattcagcca tttgatatgg tcatatatcc ctcattgtag 2813641 cagaaaacac tgactttgaa aatcattttc aattagtttt atggacataa ttgacgttta 2813701 tgggtttttt atcacaagat tacttcttga tttctctgat ggagccgtcc ttcagcttca 2813761 attttaaatc gatatgatca taatgactgt ccagattaaa tgctgccagc acactgtgta 2813821 tcacttctgt ttcagccatt tggtctgtca cggaaagctc gctcaaaatc attttcatct 2813881 catctaacgc ttcttctcct tcctgattga caccggagag cttatcctgt atttccgctt 2813941 tttcctgagt cccgttcttt gtatagattc cttcataacg gttatgctca ccatccccgt 2814001 agctcacacg aagcgaaaaa ttactgtagg gaacggactt cagctgggtg acggctgtat 2814061 tttctccttc tgcctgatgc tggtcttcat tgaaacggca gcccgcaatc agaaccactg 2814121 cgagacatac agccccggct gctctgatca aatgcatatg tttcccccct gtaggattcc 2814181 atttatttta ggtatatcca gagaatgaaa tcctcattca gagaagaatt gaaaaagccg 2814241 gggcatttaa cgccacggct ttttctttaa gattcggtca tttgtaaaaa ggtttcggcg 2814301 tcacgcacag ccagcttgat ggcattctcc cagaaatcgc gctttgtgat gtcagcgccc 2814361 aaatgcttca tcgccaaatc ctccactgtc atagaagccg tatcgcgcaa tagcgccata 2814421 tacttctctt cgaatgtgtc tttttcttca agcgccaacg cgtaaatacc aagagaaaac 2814481 aggtagccga atgtataagg gaaattgtaa aacggcaccc tcgtgatgtg aaaatgaagc 2814541 tttgatgccc aaaaaagcgg atgatattct tctaacgcat tgcagtatgc ctctctttgc 2814601 gcctcttcca tcagctcatt caagcggctg gccggtacca ctccccgctt tcgttcctcg 2814661 tagaatctcg tttcaaatag aaatcttgcg tgaatgttca tgaagaacgc aacgcttctt 2814721 tgcactttat cctccagaag aacaagcttt tcttccctcg tctcggcctg ctggacagtc 2814781 gcgtccgcca ctatcatctc tgcaaacgtt gaagctgttt ctgcaacgtt catggcgtag 2814841 gaacggttta acggcctgac gttgagcatt gcttcctgat ggaacgcgtg cccgagttca 2814901 tgcgcaaggg tagagacatt tgaggcgctt cccgaaaatg tcatgaaaat ccgggattcc 2814961 ccgctgtccg gaaaactggt gcaaaagccg ccgactcttt ttccgctcct gtcttccgcc 2815021 tcaatccagc cgtcccgaaa cgctttttca gtgaatgagg acagcttttt gccaaacgtt 2815081 gaaaactggc tggtaatgat atttgcggct tcatcatacg aatagacctt tccgtcagaa 2815141 ccgatcggtg cctcgacatc gtaccagctg agtttttcaa ggccgagcat ggatgctttc 2815201 cggttcaaaa actgaacgaa cggcttcttg ttttcagtga tgacctgcca catcgtatca 2815261 agtgtttctt ttttcatcct gttaatttgc agcggttcct tcaggacatt ctcccagccg 2815321 cgcgctttat aggtttcaag ccggaatccc gccaaatgat tcagcgtgct gctgaaaata 2815381 tcttgcttgc tctcccaagc ttggcggaaa cgttcatata ctgtttttct gacagtacgg 2815441 tcttgatgat ccatcatatt ctccgcctga ccgacagaca attgcttgtt ttcaccgttt 2815501 tcctcatacg ggatcgtcat tttcccgaca accatattgt ataagtcact ccaagcgtga 2815561 tatccgtcca ccgcaaggtt tccgatcagt ttttccttac cggggctaag cttttcggca 2815621 accctctgtc ttctttcatt taatatgtaa gaaacatcgc gcaatcccgg ttttgttaac 2815681 aattcattcc acacgtcttg attaatgtcc acaagtttat gatctaatgt aacgagcgac 2815741 gattgaaaat ctgcggaaag ccgattcatg aggcctgatg ctctatagcc ttttgatcat 2815801 tgatattctg ggcctggagg caagcaacaa aagcgccggc ctgctgaagc ttgacggatg 2815861 tctgttcgaa taaatcaagc aacgcggtca gcccttcagc ctcttcaggc gattcaggca 2815921 cctgaaacgc atcagtcctg tcttgaaatg cacgcagact ttgtgacagc ttctcaatat 2815981 aacctttgaa ttcttccgat tggctcccgc ccttaaaaaa tgaatcaaga tcccatcttt 2816041 ggcctacccc ttgcagcgcc atatcacaaa acccctttcc ttctttcgtt ctattataga 2816101 acaattctga attattgtat aaaaatttct attacaggcg tcatttcgtg ttcaggatag 2816161 tacaatagct gtagcagttt aataggaggg ttaggatgaa taaaaaaata gccatcgtga 2816221 caggagcgtc cagcggcttc ggtctgctgg cagctgtaaa gcttgcccga tcatttttcg 2816281 tgatagccac atcaagacag cctgaaaaag cggaacagct tcgagaattg gctgcagcac 2816341 acaatgtgtc tgattctatt cacattacag ctctcgatgt caccgatgaa caatctatag 2816401 tctcattcgg aaaagctgtt agtgcttacg ccccgatcga tttactcgtt aacaacgccg 2816461 gaacggctta tggaggattt atcgaggatg tgccgatgga acatttcaga caacaatttg 2816521 aaacgaatgt cttcggtgtg atccatgtga caaaaaccgt gctgccttac ataagaaagc 2816581 atggcggcgc aaagattata aacgtgagca gcatcagcgg actgacagga ttcccagcgc 2816641 tgtcgccata tgtttcttcc aagcatgcat tggaaggttt ttctgaaagc ctgcgtatcg 2816701 agctgcttcc gttcggtatc gaaaccgctt tgatcgagcc gggctcatac aagacatcga 2816761 tctggtcaac gtcattatca aattttatgt cggtgcctgc tgacgattca gcctatcatc 2816821 aatactataa aaagatcctt tcctatgttc aaaaaaacgg agaagaaagc ggagatcccc 2816881 aagaggttgc cgacctcatt tatcaattgg caacaaaaca gcacataaag aatttgcgat 2816941 acccgatcgg aaagggcatc aagctcaccc tgctgttccg atcgcttttt ccttggtctg 2817001 cgtgggagtc tatcctgaag aaaaagctat tcagctgatc taaattataa ttattataat 2817061 ttagtattga tttttattta gtatatgata taattaagtc aacagatcac aaggaggacg 2817121 ttatcttatg aaaactgaaa acgcaaaaac aaatcaaaca ttagttgaga attcactgaa 2817181 cacacaatta tcaaactggt ttcttttata ctctaagctc caccgtttcc attggtatgt 2817241 gaaagggcct catttcttta cattgcacga gaaatttgaa gaactttatg accatgcggc 2817301 tgaaacagtg gataccatcg ctgagcgcct gctggcgatt ggcggacagc ctgttgccac 2817361 agtgaaagaa tacactgagc atgcatctat cacagacggc ggaaacgaaa catcagcatc 2817421 agaaatggta caagcattgg taaacgacta caaacaaatc agcagcgaat ctaaattcgt 2817481 gatcggcctg gctgaagaaa atcaagacaa tgcgacagcg gacttgtttg tcggattaat 2817541 tgaagaagtt gaaaaacaag tgtggatgct ttcctcttat ttagggtaac aaaaaagctg 2817601 aaccttaatc gggttcagct ttttgttttt tcttagcttg aactgctttc tgtctgcttg 2817661 gtcagtgttg cgttcaacgt tttcgttttt ccctttcgca gcacttggat tgttgtttta 2817721 tctccgactt ttaagtcttt gtaaaggatc tgacggatat ccgcactgct ttccacgtct 2817781 ttaccgttta gtttgacaat gacatcctca gatttaatac ctgctttttc tgccggcgaa 2817841 tttgcttgaa cttcttttac ataaacacct ttgcccaatt gatctccaaa caggccgagc 2817901 gtattttcct gataggtttc aggaacttgt gacatgtcaa tcatctgcac gcctaaaaac 2817961 ggacggtcca ccttcccgtt ttgcagcagc tggtcaacaa tcggctcgac atcattgctt 2818021 gggatcgcaa atccaagtga ttccacgccg ctttcgctca ccttcaagct gttgatgccg 2818081 atgacctggc cgcttgcatt gattaatggg cctccgctgt tccccggatt gatcgctgca 2818141 tcggtttgca gcacgttcat ttccaccgtc ccctgtgttg tatccacatc aattgtccgg 2818201 ttcagtccgc taatgatacc ttgtgtcact gtaccggaaa actgctgtcc gagcgggtta 2818261 ccgatagcga ttaccttttc gccagtgcgc agctgtgaag agtcaccaaa gctcgccact 2818321 ttttttacat tcttgccgct gatttccaaa actgccaaat cagtaatggt atcgctgccg 2818381 acaagcttgg cagtttccgt ttctccgttg tatagcgtaa cagtcagctt gttcgcgcct 2818441 tcaacgacat ggttgtttgt aatgatatac gctttatcgc tgtctttttt gaaaataaca 2818501 cctgacccgg ttccgctttc actttctgag ctggagcctc ctcccgtgcc gaatgtgtta 2818561 ttttgagagg tttggatatt tgagattccg acaatcgtag gctctaaatc ctctaccata 2818621 tcagcgatgt ttgatgcgtt cgttatcggc gccgttgtaa aattatcaga ctgcacctgt 2818681 ttatttgcgg aagcggtttc ggtcgcctga ttttggtctg acggcagata aggcgcgatg 2818741 ccaagcatga ggcccccgcc gataataccg cctaaaatcg ggctcagcca tgcggctctc 2818801 cgtttctttt cttttttcac agccgtttct tgcttttcca tttctaaagc agaagccgtt 2818861 tcctgccgtc ccgcttcata cgacacaggc gcgtcaagca attcttgttc agaatgtcca 2818921 atcagcttct ggttttctgt attctgctgt tctgtatgtg aaggttcagt ttgatgttga 2818981 tcgttttggc catcacgtcg ataatccatg ttcttacact cctttaacgg ttattcattt 2819041 atcgttacat attcatcgca tgtacaagtt caattgtccc aataatgagg agaaaagcaa 2819101 agcaccaaaa tagaatatgt ttgatcatcc tacatcttcc tcgctctttt tctcttcctt 2819161 tcttccctta accatatcat aaacaaacat tgtgggataa aaatgaaaag aatatgtgaa 2819221 attatgaaaa ttgcctgccg tatgttaaaa ctagtttata atgacgttga aaggatgtga 2819281 agagccttgt catacaccat ttatctagtt gaagatgagg ataacctgaa tgaactgctg 2819341 acgaagtatt tagagaatga gggctggaac attacatctt ttacgaaagg tgaagacgcc 2819401 agaaagaaaa tgacaccgtc tccccaccta tggattctcg atatcatgct gccggatacc 2819461 gacggctata cattaataaa agaaatcaag gcgaaagatc ctgacgtgcc ggtcattttt 2819521 atttccgccc gagatgcgga tattgacaga gtgcttggct tagagcttgg cagcaatgac 2819581 tacatttcaa agccgttttt gccgcgggag ctgattatcc gtgtgcaaaa gctgctgcag 2819641 ctcgtatata aggaagctcc tcctgtccaa aaaaatgaaa ttgccgtctc ctcgtatcgg 2819701 gtcgctgaag acgcccgcga ggtctatgac gaaaacggga atatcatcaa tttgacgtca 2819761 aaggaatttg atctgctgct attatttatc catcataaag ggcatccata ctctcgtgag 2819821 gatatcctcc taaaagtgtg gggacatgac tacttcggaa cagaccgggt cgttgatgat 2819881 ctcgtccgga gactgcgcag aaagatgcct gaattgaagg tggagacgat ttacggtttc 2819941 ggctacagga tgatgtcatc atgaaaaaca agccgctcgc gtttcagata tgggttgtca 2820001 tatccggcat cctgttagcg atatcgattt tactgcttgt gttattttca aacacgctgc 2820061 gagatttttt cactaatgaa acgtatacga cgattgaaaa tgagcagcat gttctgacag 2820121 agtaccgcct gccaggttcg attgaaaggc gctattacag cgaggaagcg acggcgccga 2820181 caactgtccg ctccgtacag cacgtgctcc ttcctgaaaa tgaagaggct tcttcagaca 2820241 aggatttaag cattctgtca tcttcattta tccacaaggt gtacaagctg gctgataagc 2820301 aggaagctaa aaagaaacgt tacagcgccg acgtcaatgg agagaaagtg ttttttgtca 2820361 ttaaaaaggg actttccgtc aatggacaat cagcgatgat gctctcttac gcgcttgatt 2820421 cttatcggga cgatttggcc tataccttgt tcaaacagct tctgtttatt atagctgtcg 2820481 tcattttatt aagctggatt ccggctattt ggcttgcaaa gtatttatca aggcctcttg 2820541 tatcatttga aaaacacgtc aaacggattt ctgaacagga ttgggatgac ccagtaaaag 2820601 tggaccggaa agatgaaatc ggcaaattgg gccataccat cgaagagatg cgccaaaagc 2820661 ttgtgcaaaa ggatgaaaca gaaagaactc tattgcaaaa tatctctcat gatttaaaaa 2820721 cgccggtcat ggtcatcaga ggctatacac aatcaattaa agacgggatt tttcctaaag 2820781 gagaccttga aaacactgta gatgttattg aatgcgaagc tcttaagctg gagaaaaaaa 2820841 taaaggattt attatattta acgaagctgg attatttagc gaagcaaaaa gtgcagcacg 2820901 acatgttcag tattgtggaa gtgacagaag aagtcatcga acgattgaag tgggcgcgga 2820961 aagaactatc gtgggaaatt gatgtagaag aggatatttt gatgccgggc gatccggagc 2821021 aatggaacaa actcctcgaa aacattttgg aaaatcaaat ccgctatgct gagacaaaaa 2821081 tagaaatcag catgaaacaa gatgatcgaa atatcgtgat caccattaaa aatgacggtc 2821141 cgcatattga agatgagatg ctctccagcc tctatgagcc ttttaataaa gggaagaaag 2821201 gcgaattcgg cattggtcta agcatcgtaa aacgaatttt aactcttcat aaggcatcta 2821261 tctcaattga aaatgacaaa acgggtgtaa cataccgcat agcagtgcca aaatagactg 2821321 tagatgtttt gcagtctatt tttttatgtg aaagaatagc cgttaaaatc tctgtaattt 2821381 gttttgagcg gctgtttgca ttgatgaacc cattttttct ctgacaaggt ctgcttcgga 2821441 tatttgactt tctccacttt gattcctctg tttcgcaagc ggctgatcat ttcgtccaat 2821501 tctctcattc tagattcacc ctttcgcttg agctttgacc attcggtcat ctcaatttat 2821561 aatataaata atacatgata aaaaaacaag ttacaataag gttaatttta taacagacgg 2821621 tgtgactata tggtcatatc ctagcaggcc tccgggctcc gaaagggtgg aaccattgaa 2821681 ggaaaaagaa aaactgatta ttgaaacagc cttaaaacta tttgcccaaa aaggatacaa 2821741 ctcaacatca gtccaggaaa tcgcaaaaga atgcaaaata tctaaaggcg ctttttatat 2821801 ttattttcct tcgaaagaag cgcttcttct ctctatgctg aactactatt atgataaaac 2821861 gtttacccga attttaaata ttaaaacgaa gggcgacagc cccagaacgg cttaccgtaa 2821921 acagctgacc gtcctctatg aaaacattct tgaacacaaa gattttatca gcatgcagtt 2821981 gaaggagggt tctctgcctt acacagaaga agtggagcaa tgcgcaaaaa aaatccgcca 2822041 gtcctcactt caatttcata tcgacagcct gctgaacatc tatggaaaaa aagcggaacc 2822101 gtacactgct gagctttgtt ttttaataga gggcatcagc cagatttacc tggaatgcat 2822161 gattttgctc gggtacactg tgaagccgtc tcaattagct gatatcatta tgaatcgaat 2822221 tgatgatatg gtaaaaggca tgtctgaacg aaacgataag cctttcatca cattggaaga 2822281 ggcgagctct ttattcggac ctcttacgca cggacggcct gacccgctga ctgaatcaat 2822341 tgtgaaaagc ctacgtgaca aaattaacag cttaaacaca aactcctctc ttgaattatc 2822401 ggagagcttg gacatacttg aagcagaaat gaagaaaaaa acaccgaagc tggcgatcat 2822461 aaaaggaatg attcataatc tgacggagtc tgaagctctc gccaaagatg cggaacagct 2822521 taaatattta ttaaaacagc aacatattta gaagaacggc tgcttaaaaa gcagccgttc 2822581 ttcctattac gcctttggtt ttaccatgtc ttccggctta accatttcgt taaattgctc 2822641 ctctgtcagc aattcaagct tcaaagctgc ttctttgagc gtcaatccct ctttatgggc 2822701 aagcttggcg attttcgccg cgttttcata accgatatgc gggttcagcg ccgtaacaag 2822761 cattaatgaa tttgacaggt tttcctgaat ggtttcttta ttaggctcaa taccgacagc 2822821 acatttatca tggaatgaat tcatgccgtc actgagcagc tgcacagatt gcaggaagtt 2822881 gtaaataata acaggcttaa acacgttcag ttcaaagttc ccctgactcg ccgcaaagcc 2822941 gattgtcgca tcgttcccca tgatttgcgc tgcgatcatt gttaacgctt cgctttgtgt 2823001 cggattgact ttaccaggca taatagagct tcccggctca ttttcaggaa tgacgatctc 2823061 cccgatgccg cagcggggtc cgcttgcgag ccatctgaca tcgttcgcga ttttcattaa 2823121 gtcagccgca agcgctttta atgcgccatg cgcataagtg atttcgtcat ggcttgtcag 2823181 cgcgtggaat ttattcggcg agctgctgaa cgtttggccg gtcagcttag tgatctcttc 2823241 tgagacaagc tctccaaact ctgggtgggc gttgataccc gttccgacag ccgttccacc 2823301 aattgcaagc gcacgcattt tatctgtcgc ttccaaaatc atttccttcg aacggtccag 2823361 catgtgaacc catccgctga tttcctgtcc gagggtcagt ggcgtagcat cctgaagatg 2823421 cgtgcgtccg attttgacaa tatcattgta tgcttttgct ttttcatcca gtgtattgcg 2823481 aagctgatca agcgccggca caagctgctc gtaaacagcc aaaacagcgg caacatgcat 2823541 cgcagtcggg aatgtgtcgt ttgagctttg gcttcggttc acgtcatcat ttggatgaat 2823601 cgtttgatca gagttcttct cttttaataa agcagtcgca cggttggcta ccacttcgtt 2823661 catgttcata ttgctttgtg tgccgcttcc ggtctgccat acgacaagcg ggaagttgtc 2823721 atcgtacttg cctttgagca catcatcaca aaccgctgca atcgcttctg ctttttcagc 2823781 gtccagattg ccgaggcgtt tattagctag agcagtgctt cgttttaaaa ttgcaaacgc 2823841 cttcacaaca cgcatcggca ttttttcaga accgatctta aagttctcct tgcttcgctg 2823901 tgtttgggcg ccccaaaatt tatcagcagg aacttttact tctcccatgg tgtctcgttc 2823961 aattctgtat tccatttatg tatccctcca taacggttgc ttcaatagat cataattcgc 2824021 caatgacaca aaaaatcctt tttatttttc gatcttggca gattttaatt ttaattcaag 2824081 atatacgcgg gaatcctttg aatatttgta ttttggattt gtcctgccgt actcctttga 2824141 tgtataagag acatcataat gctgttcaaa tgatctaatg agctgttcaa tttcttcttg 2824201 ttttccagct agccttacct gtgccacttc gtatcctccg ctttcataaa aaaacttact 2824261 ccatgaaata ctctaacaca gtatatcatt tttttaacag gaaaagataa cctctactaa 2824321 ggttttggat aagaggtgac ctcattggaa caaacagagt ttaaggaata tatacacgat 2824381 aatttagcat tggtgctgcc aaaattaaaa gaaaacgatg atctggtgaa aaacaaaaaa 2824441 atgcttgcga acggactggt tttttactat ctctatttca gtgaaatgac tgatgagaat 2824501 aaggtgtcag aagccattaa aactttgatt aaagatgagg agaccttaac gcttgaccag 2824561 gtcaaaaaac gccttgacca gcttgacgca agacctgttg aaactgcaaa aaaaacgatt 2824621 gaatcgattc tcaacggcaa ttgtgctgtg tttatcaacg gattggataa agcctatatt 2824681 ctgaccacag gaaagaaaaa aacaagaagc ctgacagagc cgacaactga aaaagtggtt 2824741 cgcggcccaa aagtagcgtt tgtagaggat attgatacaa atctcgctct gatcagacaa 2824801 agaacctctc atccgaaatt gatcaccaaa aaaatcatga tcggcgaaaa caagctgaag 2824861 cctgcagcca ttatgtacat tgaaggcaaa gcaaaaaagt ccgtcataaa agaagtgaag 2824921 gcgcggctta aaaatatcca gctggaagat atccaggaca gcggaacgct cgaggagctc 2824981 attgaagata ataaatattc accatttccg cagatacaaa atacggaaag acctgacaaa 2825041 gtatcttcag ccctgtttaa cggccgtgtg gcaattttgg tcgacagttc accatttgtg 2825101 ctgctggtgc cggtttctct cggcatcctg atgcaatccc cggatgacta ctatgaacgc 2825161 tggatttcag catctcttat ccggtcgctg cgctttgctt ctatctttat caccttgttt 2825221 ttgtcatcga tttatataac acttgtttcc ttccatcagg ggctgctgcc gaccgcactc 2825281 gccgtcacga tttcggcgaa cagggaaaac gtgccgttcc ctccgatatt tgaagccctg 2825341 ctgatggaag tcaccatcga gctgctaagg gaagccggac tgcgactccc caatccgctc 2825401 ggacagacga tcggcctcgt tgggggcgta gtcatcggac aggctgctgt agaagcgaat 2825461 ctcgtcagtt cgattttggt cattgtcgtc agtgtcattg ccctggcatc ctttaccgtt 2825521 cctcaatacg gaatgggtct gtctttccgg gtgctgcgtt ttatttcgat gttttccgcc 2825581 gctattttag ggctatacgg cattatttta tttatgcttg tcgtttatac gcacttaacg 2825641 agacaaacga gctttgggtc tccgtatttt tcgccaaacg gattctttag cctgaaaaat 2825701 acggatgact ccattatccg tctcccaatt aaaaacaaac caaaagaggt gaataatcca 2825761 aatgagccaa aaacagactc cactgaaact taataccttt caaggtattt ctattgttgc 2825821 aaatacaatg cttggggccg gacttttaac attgccgcga gcgctgacca ctaaggctaa 2825881 tacgcctgac ggctggatca cgctgatatt agaaggtttc atttttattt tcttcattta 2825941 tttaaacacg ctcattcaga aaaaacatca atacccttca ctctttgaat atttgaagga 2826001 agggcttggg aaatggatcg gcagcatcat cggccttttg atctgcggct atttcctcgg 2826061 cgtagccagc ttcgagacac gggcaatggc tgaaatggtg aagtttttcc tgctggagag 2826121 aaccccaatt caagtcatta ttttaacgtt tatttgctgc ggcatttatt taatggttgg 2826181 gggcttaagc gatgtgtcgc ggctgtttcc cttttattta acggtaacca ttattatttt 2826241 gctgattgtg ttcgggatca gttttaaaat ttttgatatc aataatttgc gtcctgtttt 2826301 aggcgaaggc cttggaccca ttgcaaactc ccttaccgtc gtttccatct cttttttagg 2826361 aatggaagtg atgctgtttc ttcctgaaca tatgaagaaa aagaaataca cgttcagata 2826421 tgcgtctcta ggatttctga ttccgattat cttatatatc cttacgtata ttatcgttgt 2826481 cggagctttg accgctcccg aggtgaaaac gctgatttgg ccgactattt ctctctttca 2826541 gtcctttgag cttaaaggca tatttattga acggtttgaa tcctttttac tggtggtctg 2826601 gattatccag tttttcacca catttgtcat ttacggatac tttgccgcta acgggctaaa 2826661 gaagacattt ggattatcga ctaaaacaag catggtgatt atcggcataa cggtctttta 2826721 tttttctctc tggccggatg acgccaatca agtcatgatg tatagcgatt atcttggcta 2826781 tatttttgtc tccctgtttc tgcttccgtt cattctcttt ttcattgtag ctctcaagag 2826841 gaggattaca acaaaatgaa aatccggatt ttatgtatgt ttatatgcac cctattgctg 2826901 tccggatgct gggacagtga gaatatcgag gaattaagct tagtgatcgg aatagggcta 2826961 gacaagcctg acgatgaaaa tttagagctg acacagcaaa ttctcgtgcc gaaaataatc 2827021 agcgccaagg agggctcttc atctgatccg acacagcttt ctatcacaaa gggtaaaact 2827081 gtccatcaaa tgatgagaac ctctgcatta aagcataagc ctacgttttc acagcatttg 2827141 cgtctcattc tgctttccaa aagcgtgatt gcggatcaaa ttggaatgga cgccattatt 2827201 aaccagtttg tcagagacaa cggaacaagg aggagttcct acgtctttat caccaacggc 2827261 cgaactaagg atatatttaa catgaatgat gaaggcgaac ccgcatccaa cgtgatatat 2827321 gatctgacag agaataataa ggtgacgatc agaacgatgg agccagttac attgggggag 2827381 atctcagaac acttaacctc tgacgattca ttcctcatcc ctcatgtcgg taaggaaaac 2827441 ggcaagctcg cgataaacgg agcctctatc ataaaaaata aattatggca ccgggacctc 2827501 accccgattg aggttcaaaa tatcagctta ttttcaggca ctgtcgaggg aggcgtcatt 2827561 gacttgaagc gcgatggcca tctcttttct tatgaagtat attcaagcaa tcggaagatc 2827621 aagacggcat acaaggacgg aaagttcaaa ttcaccgtta cccgcaatat tgaaggtcgt 2827681 ctatctgagg actggaatcc caatgaagac tcgtttaagg attcatatat taaaagtatt 2827741 gaaaagacag tcgaaaaacg agtacacgaa acagtaacgt catttattac agagaagctg 2827801 cagaaagaga tcaaagcgga cgtaaccggg ctgggaaacg aggtcagaat tcattatcct 2827861 caaaagtgga aaaagatttc aagaaaatgg gatgatgatt atttcagcaa tgcggaaata 2827921 gactaccggg tcaatgtgat tgtcagagac ttcggaacga aaggcgcaaa caaatagcag 2827981 ccgcctaatt cacgagatga tttcggtgtg cgtacaccgc cgcctgcgtc cggtcactga 2828041 catccagctt tgataaaata ttcgtaatat gtgttttgac tgttttaatc gtaataaaca 2828101 gttcctcgcc tatttctttg tttgtctttc cttctgcgat caggcagagt atttcgagct 2828161 cccgttttgt aagcgattca tgcgggagcg cgttttcacc tgagtggcgc agcctggata 2828221 atacttttcc cgccactttt gactccagct tcggctctcc cttgcttgcg gcgcggatgg 2828281 catcggcgat ttctgccgct tttgaggttt tcaacagata gctgagcgcg ccagcttcaa 2828341 taaccgggta cactttgtca tcatcaatga agctagtgag cacaataatt ttcgggtcgg 2828401 aaagctcccg gcaaatttgc tttgtagctt caatgccatc catgccctcc atgacaaggt 2828461 ccattaaaat gacatcaggc gacagttcca cagcaagccg aacaccttcg ctgccgtccg 2828521 atgcttcgcc gatgacttca atatcgggct gcgcctccaa aaaagccgcg agccccattc 2828581 tgaccatttc atgatcatca atcaataata ctcgaatcac gttcgttctc tcctttttct 2828641 tccggaaaaa tcgggacctt cacttcgatt tgagtgcctt ttccttctac tgaaatcact 2828701 tcggcgacac cgccgatttc acttgcacgt tctttcatag aattcaagcc gtatgaggag 2828761 gctttcacct ggtccatttt aaagcctttt ccattatcaa tcaccttcag acggagctgg 2828821 ctgttcttta tgcccagaat cacggttact tttgacgctt ttgaatgtct aaatacgttt 2828881 gaaagggcct cctgcacgat tctgaacaag tggtcttcaa cacccttgga tatcgctgtg 2828941 tcctgtatat cccactcaat atcaatcggc tgcttttttc ggaactcgtc caaaagctcc 2829001 gtaaggccct ccttcagccc ttttccttca agggtaacag gccgtaaatg gagcagcagc 2829061 gccctcatct cattttgggc ttcgcctgcc atatgctcga ccatcctgat ccgcttgact 2829121 gttttgtcat cagcatcctt gacatgttcc agcacggctg atgtcatcat cgatatggca 2829181 aagagctgct ggctgaccgc atcatgaaga tctctggcca atcgctggcg ttcttctgag 2829241 ataaccgact tcttcatttg agcctgccat tccgcacgtt cattggaaag tttctggagg 2829301 gatgcgactt gaagctccac gcgcttcgcc atttcgttca gctgatcagc agccaggccg 2829361 atttcatcat caccgagcgg cggtatccga taagcgaaat tgccgttttc aaaggttaaa 2829421 atggattcaa ttaatgtatc aatccttgtc ttcaaccggt tgccgtacat ataccctgag 2829481 gcgaaaccga cggtcacgct gatcagaagc aaaatcagga taaacggaat tccgaaccag 2829541 cttgatgaca gcaaaacaag cggatcgagc cgatagtaaa acatcataaa ggaaatcagg 2829601 caaacaaaaa ggagcaggct gattcccgtt gtcatgcgga tggcgcgcca ttggaggctg 2829661 gcaagcattt tttttctcat acgtacttca catccacatc accgataaat aaggaaacgg 2829721 acacttttac ccggcgcttt gactcgctaa aatcagttga cgcggcatat accttcgtgc 2829781 ttaatccgct tttcttcgag ccgatcagat taatgtctcc tataaaaaca gccgagctga 2829841 cagccacttc aaggtccgat ggtacataaa tatcaacgtt accaatgact ccgctaatga 2829901 cgattgtact ttctccctcg ggaatcatcg ctttagataa atcgattttg atatcaccga 2829961 taaaaccaga gacatttaaa tcgttcaggt caaacggctg cttcatcatt tgcagctcac 2830021 cgataaaaaa gctgcgcatg tcgggatgtt ttacatcttt tggcggctca tgatgttctt 2830081 ttttattgag attgacctgt ttctcattcg gttcaaatat cggcttccct ttgataagcc 2830141 tgtagccggc gtaaatcaga aatgcggcaa acgcatagcc gaataaatta aaggtgatgc 2830201 tgaagaggtt tttcaaaaat agaaacgcgg caaagatata catgacggag ccaagccaat 2830261 cacgggaata ttttttaagg aaatagccgg caatcagaaa aaagagcggc caaaacagca 2830321 gatcgcctat tccgataatt tgcaaaaaca tactgatgcc gaataaagca atgatcaatc 2830381 cgagaagctg tttttttgtc attcctggtg tccgcctcct ttcttctgcc tagtgctacc 2830441 gtatcgctag atccccgctg tccgttttga tgtcgattgg atgccggccg cttccttgcg 2830501 tgcctgtgat gtgatgctgt tctttatgtc ctttatcagc aaatgaatac ggcgaactga 2830561 cgtcaccgct tgctgataaa gcattgactg caaagctgcc attttgggga aggcttacat 2830621 tagcatcacc gcttgtcagc gtgacagata cgggaccggt tacctttttc aatacagcat 2830681 taaaatctcc tgaagtcatt ttcacatcaa gagagcctga tacatgaacc agatttgcgt 2830741 cccctgaagc taaatcaatg ccggctgttt tggagacggt atttgaaatg gaaacatccc 2830801 ccgatgatgc cttcactttc agatcttgaa tgcggacgtc cgtcacgctc gtatttccgc 2830861 tcgcagatac tgcgttcagc ccggaaagcg caagatggtc attcccggcc acagacacgt 2830921 caccgcttga ggttcgtact gccagatcac ctttataatc atacggaagc ctgacgataa 2830981 gagttgaacg gttaaatcca ttcaaaaatt gaaattcttt ttcctttacg gtcagctcca 2831041 gttttctttt gttttcagta acaaataact ttcctgagtc tcctgaaatg cctgccgata 2831101 tgtcacttcg ttcttccgct ataatccgga catccttgct atccgactca atgaccatgc 2831161 tgtcaatgtc ccgcggcgat gcgctggctg aatcagcttc tgtgccattt atgaaaccta 2831221 ggcctgcagc aaacacatct tttacgacga cggcgaaaaa aaccagaata ccggcagtga 2831281 tcaacagttt gccaagcatt tttttcattc ggtttcatcc ttctcattca ttctattata 2831341 aaggaaaagc ttgcgaattg atacgtgcgg aagggaagga cttgaccgca aatccttccc 2831401 cgttccgctt attcatttgc cgcttttgtc tggtctgatt tttgcagtga aagtgtccgc 2831461 attttttcaa tctccgcttc cacatcgtct gcgaattctt tacgtgtaag ttctgtgccg 2831521 gcttccgctg actttgaata attcgcgcgg atttccattt cttcaatacg attttcaata 2831581 cgtaaaaatt cacgatacgc gctttcactg tcaattttgt caaatgtcgt attcatatgc 2831641 tctttagctt tcgccgcatt tgcccgcgca atcagcgcct gttttttatc ctttacgtcc 2831701 tgaagctttg tttcaagtgc agccagctgc tctttcagat cagccagctg actgtttgcc 2831761 tgttcatagg aagctttatg ctcagccgcc ttcccttcta aatacttcat ttcagtcagc 2831821 gcctttttcg ccagttcttc ttcacctgcg tcaaatgcga gctgtgcctg atttttccgt 2831881 ttgccagcca cttcagcggc ttcttcatat tttttcttaa attgataggc aatcgtgtgc 2831941 tgtttcacaa ttgtttgctt tgcttttgcg atgtcgcttt ccatatcgcg tacatattga 2832001 ttcagcatca cctttggatt ctccatttta tcaagtcctt catgaactga cgcaacaaac 2832061 atgtctctga ttctttttaa taccatacct gattcctcct aatatattga tattattttt 2832121 tcttcaaaaa ttcttcccat tcgtcatcaa agtgagattg gtaggcagca gaagccggtt 2832181 caggatcaaa agatgataca ccgttatcag ctgatccgtt tttcatcagc ttccagccgt 2832241 aatacaccat agcggccgcc aatgcgattc cgacgacaaa cggaagtgag cagatgagca 2832301 taatggctcc gataccgccc acgatgattc ccgtgatggt ttttcccgcg gcaaaccttt 2832361 tgattcctgc gtatgtcatc aagctcccga tggcgagcgg gatgataaag ccgaagcttc 2832421 ctcctccaaa aaagacggag atcccaaata caattaataa gaatccgcct attgttttct 2832481 tgtttatttt catgcagatc ctcctttcgt tttccttgtc ttcatcttat acaagttgga 2832541 agatatgcaa aacgaatcag agattgattt ttatataaga ccggagtcgt atctcgcacc 2832601 ggacccattg gcacaaaaaa acgccatgca cgaggcatgg cgttttaaaa ccctttacag 2832661 atgaacactt gcttcccttt ctttaattag gtcggacctt tctgctttgg ccaattttgt 2832721 aaacagcaag attccgatac ccgcaataat ttcgacaatc ccaccgacag cgatcacttt 2832781 acctgagccg aaagcattag cggcataccc gcaaatgaca gctccggcag ggatcgaaat 2832841 atttgagatc atatgtataa cggcgtaaac ctgcggctga tcctcactat ccacagacgt 2832901 ctggataatc gtgtactcag gaacattaac agcactgact gcggcaccaa aggtaaaagc 2832961 agcgaaaaag acgagcggca aaaaggtatt catcccggta ataaagaaag caaatccttc 2833021 aataatgccg gcagtgacga ataacaagcc gtacctgttt accttgactt tcgccagcac 2833081 aaaccctaat aaaaacgcgc ccgcggcggt ggtggccttt aaaagcgagt atacgatcgg 2833141 ctggccgttt aaatcttccg caacgtatac ggcagagagc gcttcccatg gggcagccgc 2833201 gaaattcata aagatacagt aaatggcgag cggatataaa atctggtgtt ttctgacgag 2833261 cctaaagccg cgtttcagtc ttccgatata tgtgcctctc tgtgtaacaa ccgcagactc 2833321 tgattgagat tcaaccgcag tgtacttaat aaaaagaacg agaaaacctg acaccaaata 2833381 gagcacaagt gcgataagca tggtataaga aggactaata aatgtaagaa aagcgccgca 2833441 taatgtgaca gccccaagcc ggacaatttg agcggaggat tgcagcacag cgtttgcttt 2833501 ttgaatgccc tgttcattga cgatttgagg aatcaaagcg atagaggcgg gattgtaggc 2833561 agctccagta gctgaatgca caatcataag cgtcatgaca aaccacagcg gagagaagcc 2833621 cgcaaaatga catagaggga taatcaaaac aatcgccgcc cttgtcagat ctgaaaagta 2833681 catccaaaat ttcagcgtgg tctgtttcat aaaaggcccc gtcacaggcg ccagaacggc 2833741 ttccggcaaa aacgtgacag caatcaataa agcagtgccg atcgcacctt tgccgtcata 2833801 aattaaaaac cataatattg aattaaatgc gaacatatcg ccggatatct tgactattct 2833861 tgagaaaaac agataattga aatttctctt ccagatgcta tcactttcaa ttaaattcac 2833921 catccatcag agccccccgt tgcctatttt ttacatctat ttattacaat atctcatttt 2833981 tccatttttc agtcaataat tcataaggtt cattttttgt cgtaaaatgg gaaattgaca 2834041 gagtgaaaaa caaaaaaagc cggcatgtat ttgaacacgc cggctttcct tttcactttt 2834101 tatgattcgc tgctgtttcg gtcccgaaac acaatggcac ttctttcata ttctacatcg 2834161 ccaataccgc ttcttgcatt cacaacccgg gcggcggcaa agaaataatc ggacagacga 2834221 ttgagataac gcagcactgt ttcatgaatc tcctccgatt tcatcagcgc caccactctt 2834281 cgttctgccc gccttgtaat ggtgcgtgcg atatggagaa gcgaagcaca ctttgatccg 2834341 cctggaagaa taaatttctt cagttccggc gcttctgctg tataggcatc aatgcgcgtt 2834401 tctaaaaagg aaacagattc ttccgttagt ttatagtctt ttctttctgt gacgattgcc 2834461 agatcgcctc cgcagtcaaa cagctcatgc tggatggtca gcagctcggc tgtcagatct 2834521 tcaaagccgg gctgcccgga aagctctgcc aaagcaagcc cgataaagct gttaagctcg 2834581 tcaatcgtgc cgtagctttc gacgcgtagg ctgtccttgt ccgttctgcc cccgactaag 2834641 cccgtttgtc ccttatcgcc tgtttttgta tatagtttca taccctgaat ctcctttaca 2834701 gacttattca aacaactcag cagcctcttt tatacattca gctgtccctt tctttatcaa 2834761 ttggttcagc cgctgttcta tgttttctga ttgctgagtt tgagtcgcgg cgatgagaat 2834821 atcacctgtg cctcctccgt ctcccagcac tttcgtccgt tctgcttcgg cagccataag 2834881 agctttgatg aagaattgat ctgccgcata gccgttaatc aaaatccaaa tcgaaaagcc 2834941 ggtctgaacg catatgaaaa cggataactc tccgtcttca tatgttcgat acacgaaacg 2835001 gtcaagtctt tctgaagaag ccatcgcaca cgtctcctgc agttgaaaac cgctttctga 2835061 aagacaggcc gtaagtcctt ctatcggatc tggctgatct ggcagccgtt tatggatcag 2835121 cgtcctgctc cacgaaaacc ctgcaccgat aggcgtggag gacaatgttc gaagcgggat 2835181 ttccgtttgc agaagaatgt catcacgccc cgcttggagc aatgcttcaa atgggataga 2835241 ctgccgcttc acgctatctt tttcaggctg aatcacaatc atcggtttag gtgagctttg 2835301 atgaaccaag gcggtgacat ctgtatcgta caccgccttt atgctttgtt ctgtaacagc 2835361 atattccggt ttttgcttag gcccggcggt accgtttttc ataaacatga gcccatcaca 2835421 gtacaggctt gcggtgttca gatcatgaaa aacgctgaca gctgccaatc cgctttctct 2835481 cgtcaggcgt ttgatcagat caagcaggtc tttttgataa gccagatcga gaaaattagt 2835541 cggctcgtcc aaaaataaaa tacgcggctg ctgcgccaaa gcttgtgcca aatacacccg 2835601 ctgctgttcc cctccgctta gttcgcgaat cggcttttgc gcaaaatcgg ccactcctgt 2835661 ttgctccatt gcttcctgta caatggcttc acccttttca gtctgctgtc tgaacagccc 2835721 cgtttggaat ggatatctgc caaaggctac agtttcttcg acagtaaagg tgaaggcttg 2835781 atccattttt tgcggcagga cagccatgat ttgcgccagt tccttcggtt tatagtccgc 2835841 cagcagtttt ccggccagat aaaccctgcc tttcttggcc ggcagcgtac ctgtcagcaa 2835901 gtgcaaaagc gtggtttttc cgcttccatt agggccgaga attccaagaa attctccctt 2835961 ctccactgtt aagctgacat tgttgattag gcggctgtcg ccgtatcctc ccgacagccc 2836021 ttctgccttc atcataagct tctccccccg cgatgctgcc gaattaaaat aagagcgaac 2836081 acaggcgctc ccgccaagga cgtaatgatc ccgatcggca gttcaatcgg ctcaatgatg 2836141 gttctggaaa gcagatcggc taaaacaaga aaccctgccc caagcaaggc ggacaacggc 2836201 agtaaatgcc gatggtccgt tccccacaaa agccttgtga tatgcggaat cacaaggccg 2836261 acaaagccaa tcgtacccga tactgccaca gcgcttcccg tcaaaagaga tccggctatt 2836321 aaaatcatca tcttcctctg ctgaacgctg actccaagaa gctttgcttt atcttctcca 2836381 tatgtcatca cgttcagttc ccttccgttt ataatcaata aaatggttcc caaaagaaaa 2836441 aacgggagaa acaaaataac atagctccag cccctcattg agacgctgcc aagcagccaa 2836501 tgcacaatcg gaagcaggtt gtctcctgtc aaggcgatga taagagaaat aaatgcgcct 2836561 aaaaaagagt tggtgatgac accggtcaaa atgagggtgg aaacagacat cgaagcatga 2836621 acgaggcggc tgaagaaaag gaccgccgcc atcgtggcca gtgccgcggc tacactcaaa 2836681 accgggagtg taaaccctcc gatgacagga aggtgcaaac ctaagaacag agtcacaaca 2836741 gctccgactg aagcaccgga tgacacacct agcgtatagg gatcagcaag cggatttttc 2836801 aacaatcctt gaaaagcggc ccctgcaata gaaagagccg cccccacaag ggcggccagc 2836861 acaactctcg gcagtctgat attcatcata atattagtgt acatcggatc atcagaaccg 2836921 atagagccgc cgaaaccttg atgccaaaag acacgaaaaa cagcgggaat aggaatatgc 2836981 aggctgccgc aagaaattcc taagatgatg ctcacggcta aaaatgagaa accaatgata 2837041 tatgcggcat aacgattatt ccttaaacgt atccgggtaa atgctttccg caagttcttc 2837101 gaccccttcg atcagacggg gaccggaacg tgtcacaaga tcagggtcca catcatatac 2837161 acgatgatgt ttcacagcat tgatttcgct ccagccatcg cgtttttcca cagctttcgc 2837221 tttcacaccg tccgttgtaa caattgcatc aggattgagt tttacgatcg cctcgtctgt 2837281 catttgcacc catcctgtct gatccgcagc tgcgttttta gcatggatga catttagcat 2837341 ttcattcata aacgtatctt ttccggttgt ataaatgtca ggatcaggag aaacctcgat 2837401 aaatacgctt ttctcctcgt cttttgaaat ggttttcgct ttttcttgaa tatcctttag 2837461 atctgatttc atgcttttca cgagctgatc ggcttttttc tccgccccgc cagcttctcc 2837521 gatcatttcg attgatttgt acacctcgga gaatgattgt gcatcattga cagtcagcac 2837581 tgtaatgccc gcgtccttca gctgtttgat ggcatccgct gatgctgaca tggaagactc 2837641 atgggccaga acgagatctg gttttagaga aatgactttt tcaacgttta cattcatatc 2837701 tccgactttc tcaacctttt tgacttcctt tggataggta tcgtttgtgg tgacaccgac 2837761 cactttgtca ccaaggccga gtgcgtatgt aatttctgtg ttgctcggca ttaatgaaac 2837821 aatctttttt ggctcttttt tgatggttac atcttggttt gacgcatcat caatggtgac 2837881 agggaacact tctgtttttt gttttgcctt tgaatccttc tgatccgcag gattgccgca 2837941 gcctgccagc ataacagcag ccaacagaag cgcagcccat atcccggctc gttttttcat 2838001 aatcttttcc tcctaaacga actaaaaaag catctctacg acggtaaaga tgctgtaaac 2838061 aacacaaaaa agcctattgt ttacacatca tctgtcctcg cagaattcgt gctgatcaaa 2838121 caggcaggta tcctggctct tggcgcttgg ccaattacag tggcgggacc gcaccggctt 2838181 ttaccggttt cccttttaag ccggctgttg ttcacggacc ggcacctatt tgacattcgt 2838241 atccgttttt cggagtaatt atactatatg actgacaggc ttgtatatgt gtcctgaatg 2838301 acttttcccc atattgtgta tggaagcaaa atcctcgtaa acactaaatt tgatcttgta 2838361 tacttaatac catcatctat caaaaggaat gattcttatg gatttacagc taaaagaaaa 2838421 actcgtctta atcaccggct cgacgtccgg tatcgggaaa gccgccgcaa aaagctttct 2838481 gcaagagggt gcggcagtca ttgtcaacgg acgcaaacag gagactgtcg atcgcaccat 2838541 tgaagagctt tctggctatg gaacagtgca cggtgctgct gccgatttgt caaaaacaga 2838601 tgaagcagcg gcttttatcg aaaaagtaaa tgaaatcggt gatatcgata tccttgtcaa 2838661 caaccttggt ttcttcgagg taaaagactt cgccgatgtg acagatgaag agtggaatca 2838721 atatttcgaa gtgaacgtga tgagcgccgt tcggacaagc cgtcacttcc ttccaaaaat 2838781 gcttgccaaa aacagcggcc gcattttaaa tattgcaagt gaagcaggcg tcaaaccgct 2838841 gccaacgatg attccatact caatgacaaa aacggcactg atcagccttt caagaggaat 2838901 ggctgaaatg acaaaaggca caaatgtgac ggtcaactca gtgctcccgg gacctacttg 2838961 gacagagggc gtggcctcct atatggaagg cgccgcacaa gcagccggac aggatacaga 2839021 tacatttatc aaagactatt tcaaggtcaa tgagccaacc tcacttattc agcgatacgc 2839081 gacagcagaa gaagtcgcca acacaatcgt attcctcgcg tctgacgccg catccgccat 2839141 taacggcacg gcacagcgtg tggaaggcgg cattatccgt tctctgtagt ataaaaaaac 2839201 gcatccgtgt ttcggatgcg ttttttttat acgtctccag caaatggtac cggctgatat 2839261 ccgcctgttt ccagttgtgc tgaaaacaac cctccagcgt gaggctgctc gtatctctct 2839321 ttttctgtca tttgttctgt tgccgttgta atgtaaaggg tttttaagtc tctgccgccg 2839381 aacgcgcagc acgtgacata tttagccggc acgctgattg aattgatttc ttttttctga 2839441 aacgggtcaa tgtgaacaac gcggctgccg ccaaacagcg ccacccacag catgccattt 2839501 tggtcaattg tcatgccgtc cggcaatccg tctgactgat caaaacgata gacaggttct 2839561 ggattcgaaa catctccgct ttgaggatca tagctgtaac gtacaatctc ctgggtcggc 2839621 gtgtcgatgt aatacatcaa attccgctcg cggtcccaat ccaaaccgtt tgaggtggag 2839681 acttgatcct tgattttgac aagactgccg tctagattca aacggtacag cgacgcctgt 2839741 ttttgctcgc cttccatgct cgtcgtcccc gcccaaagcc ttccgtacgg gtcacattta 2839801 gcatcattaa atctcaggct ctcatgcatg tccttcggct gtttaatttt ttccaagctg 2839861 tcatcccgaa gatgatacag gtaaaacccg tccttcatcg tcataatcag ttcatccttt 2839921 gaatatttcg caagcgccgt cacaaaggat ttgaatttga ttgatcggtt gattttttct 2839981 tcagggtcaa agatgtggag ctcgctcccc aggatatcaa cccaatataa gcggccgttc 2840041 tcttcatccc ataacgggcc ttcaccaatc actgcccgag tgtctgcttc caatactgca 2840101 tccatgtgtt acacctcttt agcttcagtc tatatattgt tattcccggc aaagaggtgt 2840161 ccaaaccact tgatgtttat tgttttttaa aaaggatggt aatgaccgtt ccaatgttcg 2840221 ttctgctgtt cacatggatc gttccgttat gcagatggac aagctccttg gcaatcgcga 2840281 gcccgagacc cgttccggca gttgaatctt ttgtgttcgt ccctctgtag tagcggttaa 2840341 acaaatgggt gatcgtttct tcatccattc ctttcccatt gtccttcact tttaaagaaa 2840401 tatgattttt tgtttgctcc agaatgactt gaatctctgt tcctttgccg ttgtgcttca 2840461 cggcattccc aaggaggttt tctaatatgc gcctgaacca cgcttcatca agggcaaatt 2840521 caatatgctc ttctttggat acaaacgaga tatcatagcc ttcagaaaac ggatttttct 2840581 taaaatcctc aatgacattt ttaaaaaacg ggataaggct agtgagcttt ctctcaatag 2840641 gaagagcatc atttttcagg cgatacgtta aatttaagtc ttcaatcagc ttagacatgt 2840701 attcagattt ttctctgaca acctgcccca tttctttcac ttcttccggc gaccagtcat 2840761 actgcttcga ctcgagcatc atgctgtagc cgtaaatgct gctgagcggt gtttttaagt 2840821 catgtgacaa accggcaatc cattcttccc ttgtcgcctg gattttttct ctgtttcttt 2840881 tatcccttct cagcgtttca gtcagctgat ccattgattc aaatatctca ccgaagaagc 2840941 ggtacggctg tttgattttt ccctttttat ttttgctgac aggacggcct tcccggtttc 2841001 tgggctcctc aagcttccct tttgacagat tgaccagcca tctaatcgtg tgaaaaatcg 2841061 gcagcccgaa tcggaacata taccaaacgg tcatccaaat gatatacatg aacaaaacgg 2841121 ccatcacgag aaacatcgct tttaatacaa ccttcaggaa tgatttgtta aactcctgat 2841181 cggttacata gactgggttc ggcaccgtag cgaccatcca tctgtcttta ttgaggatct 2841241 taacggaaat ttcccgctta tagttccaag gcttagagct gtatttaagc agctccagct 2841301 ggttcatcgt ttttctctcg ctttttgtgc tgttgatgct gtcgagaatc tttccattgc 2841361 tgtctaacag gtaaatggcg ccttttttcc gtttaatata gtcgatggta ctagacttat 2841421 agtgcgctag tgagtctatc ttttgttcac gcttttcaac ggaagtcagg agctgttcac 2841481 tttttgattt ccagccggac aatagaagat acgacttatc ttcaatattg atggcccaat 2841541 aattcagttt atagttatga agctttttgg ttttataaat agacaaaagc tctttcttgg 2841601 tataggtgcc cggcacgtct tttggcacgc cgtaggaata atcagtgttt ccttccgaat 2841661 caatgatttg catccagccg tgctgtttat caacagattt cttcaggaaa ttatccactt 2841721 cccatgtccc gtcttcgttt acatcgagat atgcctcaag tgtgtcggtc gttgctttcg 2841781 tcagccctga attggattcc gcatcgctaa aacgggcgtc taaatagaaa aacgatgcaa 2841841 caagcataac cgtaagcagc aggatcacaa tcagcatctg gccgaaaaag tgaaacaaaa 2841901 acttccatct taacctcatg accgcttgcc ttcaggattt gggataaaac gatagccgag 2841961 acctcgaacg gttacaatat actccggatt gctcggatcg cgctcaatct tctccctaag 2842021 cttgcgaata tgaaccatga cggtgttgtt gtcaccgtag gaaggatagc cccatacttt 2842081 ttcatatatt tgatctttgg aaagcaccac gttagggtgt tcacaaaaat actgcaaaag 2842141 ctgcagaagc tgggctgaac aggcaacggc ttccccgcct acgatcaact cggcattttg 2842201 cggagaaaaa gtaaagtaat catatgtgta ggtttgattt gaactcgttt ctttcgattg 2842261 atatgtacgc ttgagatgcg ctctgatccg cgccgctaat tccagcggat taaatggttt 2842321 tgtgatatag tcatcagctc caaccgcaaa gcccgataat ttgtccgcgt cggatgatct 2842381 tgccgtcagg aaaaaaatcg gagcgtctga atactctctg atcaatgtgc aggcttcaaa 2842441 accggacatt ccgcccatca tgacatccag cacaatcaag tcaaccttat tggccttcac 2842501 aacgggaatc gcttcttctg cgcttgccgc atccagtata tttcgataac cttctttttc 2842561 gagaacgcgt ttgatcatgt ccacaatcgc tttctcatcg tctacgatta aaattgacgc 2842621 attttccact tttatgttcc tttctgtcac tgtttttttc atcttatcat tatatcgttt 2842681 atttatggta catttttgaa tacattggag ccttggcaaa tcaaaacagc aaaaaaggag 2842741 caaacaagcg ctcccttttg atgttttttc atatgaaaat attatgagtt ctcatctacc 2842801 atgtacaaaa taaactccca aaaccccggt acatcctgac ataaaagcat atcagccttt 2842861 tcaaacattt tgatcttcag ctcttgctct aaatcttctc tttcttgata ggacgtattg 2842921 ctgagttttt ttctgatcat cggtgaaaag catgcaatca ggtgctcaat gtcataagtc 2842981 tcgtcttttt gtttcttttt ttgttcaaac tggccgtcca cagcttactt ttcccccttt 2843041 ttttgcgccg ctaactgctt tctgatattc tccagcccct ttttatgaat gttggagatg 2843101 ttttgtcggg actcccctaa tgaatctgca atctcctgca tcgtggcacc gtgaagatag 2843161 actttcgtca gcacactttt ttgtttgtca gtcagcttct ggatcgcttg gtagagctgg 2843221 taatcctgta catgctggct caaatcatcc tgcctgtcta aaaattcttc aaatgcatcg 2843281 ctacctgttt cggaagaaag ccgatctccc gcctccggat gatcaaccgt cagtggatac 2843341 cgtttttggt ttttgcgaac ccgcttatca aaatcaatag aaaagatgcg aatcattgaa 2843401 ttcatatact tgacgatgcg gatttcttta taaaattgct taaatagctc gtccaatgat 2843461 cttgcatctt tttcgttagg gctttccatt acgtttttga acaaacggta atgctgagga 2843521 ttgctcaaaa aatgcttcac gatgggatgc ttcattatct ccttacattt tgaccgtaaa 2843581 agactttgat agtccatcaa accgcctccc tactaaatta aatgaaggaa agcaaaaaaa 2843641 agtaaactac tactttccgc ctagtgtctt ccaaaatact ttgcagcagt ttacgtttta 2843701 tcggttttcc tcacttacat acatgactgc agaaaaagaa gggaggtatt ttcctatgga 2843761 tcaggttttt atagaggaag tcgtaaaaca gatcggcaat ttggggtttc ccgcgctgat 2843821 tgcaatgtat ctgctgaccc gattcgaaaa gaagtttgat caactaatag aactaatgac 2843881 agaactgaaa gatcatgcaa aaaaataatt tttcaatcga agttgacttt tcactggttt 2843941 ttttcactta acaaaacaga agggaaaacg aaaggccttt caccttctct ttctgctatc 2844001 acatttaaat gtaaggagga aacatttcat gaaaaaacaa aatgacattc cgcagccaat 2844061 tagaggagac aaaggagcaa cggtaaaaat cccgcgcaat attgaaagag accggcaaaa 2844121 ccctgatatg ctcgttccgc ctgaaaccga tcatggcacc gtcagcaata tgaagttttc 2844181 attctctgat actcataacc gattagaaaa aggcggatat gcccgggaag tgacagtacg 2844241 tgaattgccg atttcagaaa accttgcatc cgtaaatatg cggctgaagc caggcgcgat 2844301 tcgcgagctt cactggcata aagaagctga atgggcttat atgatttacg gaagtgcaag 2844361 agtcacaatt gtagatgaaa aagggcgcag ctttattgac gatgtaggtg aaggagacct 2844421 ttggtacttc ccgtcaggcc tgccgcactc catccaagcg ctggaggagg gagctgagtt 2844481 cctgctcgtg tttgacgatg gatcattctc tgaaaacagc acgttccagc tgacagattg 2844541 gctggcccac actccaaaag aagtcattgc tgcgaacttc ggcgtgacaa aagaagagat 2844601 ttccaatttg cctggcaaag aaaaatatat atttgaaaac caacttcctg gcagtttaaa 2844661 agatgatatt gtggaagggc cgaatggcga agtgccttat ccatttactt accgccttct 2844721 tgaacaagag ccgatcgaat ctgagggagg aaaagtatac attgcagatt cgacaaactt 2844781 caaagtgtct aaaaccatcg catcagcgct cgtaacagta gaacccggcg ccatgagaga 2844841 actgcactgg cacccgaata cccacgaatg gcaatactac atctccggta aagctagaat 2844901 gaccgttttt gcatctgacg gccatgccag aacgtttaat taccaagccg gtgatgtcgg 2844961 atatgtacca tttgcaatgg gtcattacgt tgaaaacatc ggggatgaac cgcttgtctt 2845021 tttagaaatc ttcaaagacg accattatgc tgatgtatct ttaaaccaat ggcttgccat 2845081 gcttcctgaa acatttgttc aagcgcacct tgacttgggc aaagacttta ctgatgtgct 2845141 ttcaaaagaa aagcacccag tagtgaaaaa gaaatgcagt aaataaaaga cttgcggctt 2845201 gcagagagca ctcgttctct gcaagccttc ataaggagct gaaccagtga aacatcaaaa 2845261 cccttcaaaa cgcttattgc ggctctccat aaagtacttg ctggccgcag cagcagtggt 2845321 gttgacctat tttgctgtca tctatatatt gttttcttta gcgggaacga gctaccgctc 2845381 agcagctcat gtcctgcttt ttgccgtggt attccttgtt ctcggattat gctttgaacc 2845441 atttgaacgg ctgatgatac atagctttac atttttcaag acaggaaaac gtctattcat 2845501 tctccttgct ggcatcgtac agctgctgtt tttgtggatg actgctcata caacagacca 2845561 attgatcagc gacatctggc tgtccaccac agaagaaatg attgtcgcag ccgttttttt 2845621 gattttagac aaatgcaact cggctcttcc cagctaaaaa aagaacgcat tccaattgga 2845681 tgcgttcttt ttattcatag cgaagcgcgt ctacaggctg aagcttcgaa gccttgatag 2845741 acggaagcaa gccgaagata atgccgactg ccattgaaaa gatgagtgct ccgacaacag 2845801 ctggaatgga gacgataaaa ggcatcggaa aaatgaccgt cagcagcttg gcgatgccga 2845861 agcccgccag cacaccgagt attccgccaa tgcttgtcag cacgacagcc tcggttaaaa 2845921 attgaaataa aatcacacgc cgcttagcac cgagcgcttt cttaattccg atttccctcg 2845981 tgcgctccgt tacggaaacg agcataatgt tcatgacgcc gataccgccc accaaaagtg 2846041 aaatactggc gataccgcca agcagcaatg caaatgactg attaaaggac tccacttcct 2846101 gcgcgatctc ctgaagatcc attacactgt actctgcttt ttccagctca gcttctgaca 2846161 gtccctgatt taaaagatct gcagccatta cacccgcttc ttggatatgc tcagaagaat 2846221 cagcctgcac ggcaatctgc gttggcgcgt caaatccttc aataagcggc cacacttttt 2846281 tcggcacgta caaaaccggg ttcgcatagt cgccttcaaa catgctttcc tgttgatttt 2846341 tttctttaaa aacacccacg accttaaacg gcacaccatt catctcaatg cttttatgca 2846401 gagcttctcc gtctggaaac agttcatctc tgacagcttc attgatcatc actacttggt 2846461 gtgtgctgtt taaatcgttt tccgtcagct ttctcccttc ggttattcgg attggaaaca 2846521 tgtcgaagta atcatcgtcc actccataca cttggggata cgaaacgtta gttaaatgaa 2846581 aaacgctcgc gccttctgac aagtaatata aggataatcc tttgaccatc ggatctgatt 2846641 tgatcgcctt tactgtttct tccgctacag gcggcgcgga cgcatacgac acctgagggc 2846701 cgccgctctc ctcttctccg ccagacggct ggtagacaac attgatggcg ttgtttccca 2846761 tgccgatcat actttgcttt aactgctcac tttggccctt cagcattgaa acaatcgcga 2846821 tgattgccgc tatgccgata atgacgccaa gcattgtcag aatcgatctt aatttatgag 2846881 agaaaatgga ttgaaaggag attcgaatat gttcaagcat ggctgatatc ccctctctca 2846941 tctaatacca actctccgtc tctgataaaa acggttctgt cagctttttt ggcgacgtcc 2847001 gggtcgtggg ttatcataat aatggtcttg ccttcccgat gcagttcaga aaacagtgcc 2847061 aaaatttgtt cacttgattt ggtatcaagc gccccggtcg gttcatcagc taaaataaac 2847121 ctcggctgat tgacaagggc cctcgctatc gccacccgct gcttttggcc gccggacagc 2847181 ttaggcggtt tgtaggagac cctgtctttt aatccgactt tttccagcgc ttcatatgcc 2847241 cgttgccttc tctctttttt cttcacttta ttgtagatca tcggcagctc gacattttgc 2847301 agcgcggtga gacgcggcag caaatgaaaa gtttgaaaca caaacccgat tgattcattg 2847361 cgaatttcgg ctaaagcccc gtctttccct ttcaatatat cgatctggtc aagcgtatag 2847421 gttcctgagg ttggcctgtc caaacagccg ataatattca ttaacgttga ctttccagaa 2847481 ccggaaggcc ccataatagc taaaaactcc cccgcctgaa cggtcagatt gatatgtttc 2847541 aagattggaa cttcttcttt tcccagcttg tacgacttcg aaatattatt cagtgtcagc 2847601 attgactgta acctgctttc cttccttgac cgcgggatca ggatagatca cataatcttc 2847661 cggcgtcagg ccgctcttaa tttccaccat gtcattttca tcagtctctc cgatttcaac 2847721 aggctgctta accgctttgt gattctcatc agctttccat acgtacggtt cgccgtcatc 2847781 ctgaatgacc atgtcggacg gcagcttgat cgtgtccgca tcagcattat cactcatcac 2847841 ttcgatgttg acatgatagc cgacttcaag acctttatgg ctgtctaata aaatggtgaa 2847901 aggatagtta gaggactggg gattcatttc ttcatcagca aagctttctg attcttcacc 2847961 ctcgcctgct cccgctggaa gcttgccgat cgaggtgacc tttcctttcc actcgccctc 2848021 accgcctgtt ttcagcgtga ccctgacttt gctgcctttt ttgatcgtgt ccattaacag 2848081 ctcattgatt tggcttttga ccagatattt gcctgtcgaa acaatctgga tatacgggcc 2848141 tgctgcctgg tcgcctgttg caccgtcagc gatatcctga ttgacgcttt gaacgattcc 2848201 gtcatgcttg cttgtaatga cattggaacc tttgtttttc gtcaggccag ccagttcttt 2848261 ttgatgctgc ttcagttcaa gctggcttgt tttcaaatcg aaattggttt gatcaagttc 2848321 atcttgaagc tggtttttct cttcttttcc tgcaactttc agcttttttt ccgtttccgt 2848381 tattgatttt tgcaaacggt tgatttgcag atttgtcatt tcaatttgca aattggcttg 2848441 ctccacttca tcagaatgat cctcgccctc atactcaaaa agcttatcgc cctttttaac 2848501 ctgatcgcct tctttgacgt atgttttttt aatgctgcct ttttctgaat ctatgtatac 2848561 tttctgctgt ttctcaggtt caacctttcc agaaaacgtt tggcctgatt ctgaatctcc 2848621 tcccatgtat accgcgaccg attcagcata gggctccgat gatacggcaa cttggttcat 2848681 gtgagtaaaa aagtaaaaac cgccagcgcc gatcccagcc aatacaagca caccggcaca 2848741 tatcgcaccg ccaataagcc attttttctt cttggacaca acgatctcct ctttctgtaa 2848801 actatgtaat attttcgaaa cattctaacc aatattatct attaattcaa aaagacttgc 2848861 aatcctttta ttgaaatgac ggaatcaaat agaaaaattg tattttcaaa gccgaataaa 2848921 aaaaatcccg gcttcaaacc gggatttttt catacagtaa ctagctcttt ttcattttta 2848981 atcaagtcat atgtcaagca tacaggttta tttgtacggg gatcagtcac gatttcggca 2849041 tcaatctgaa atacctgctt caaaatgtct ggtgtcatga cctccagagc agttccttcc 2849101 ttgatgaccg tgcctttttt gagcgcgatc atataatgag aaaaacgagc tgcatggtta 2849161 agatcatgaa tgaccattaa aatcgtccgc ccttgctctt tgttgagtct gtcaagcagc 2849221 tgcagaattt caagctgatg tgcaagatca agatacgttg taggttcatc cagcagaagc 2849281 agttccgtcc cttgcgcaag cgccatggca atccacacac gttgacgctg tccgcctgac 2849341 aatgcctcaa tcggccgttc agcatattca gccatgcctg tttcttcaag cgcccatttg 2849401 ataatccggc ggtcttcgtc atttaatctg ccgaatcctg attgatgcgg aaacctgccg 2849461 tacgacacca attcgtgcac tgttaggccg ctcggcgctt caggtgtctg tggaagaatc 2849521 gccatatctt ttgcaatgtc ctttgtagac attttatgaa tcgctttgcc gtttaaatag 2849581 acggcacctg catgtgaacg cataattctg gacattgttt ttaaaatcgt tgatttcccg 2849641 cagccgttcg ggccaattaa ggtggtaatt ttccctttag gaatcgatat atttaaatcc 2849701 tctacaatca ccctgtcgcc ataaccgatt ccaagctgtt ccgttgataa tgaattcata 2849761 ttcggccccc tcctctaatt cgctttcatc aataaataaa taaagtaagg cgcacctagc 2849821 acggaaatga caagtccgac cggaatttct gatggtgcca atacatttct cgccagcgta 2849881 tcagcaagca aaaacaggaa tgagccgatg aaggcggaga ccggtatcag cgtctggtga 2849941 cgtggaccgg tcagccttct agccacatgc ggcgcgatca atccgagaaa cgcaatgccc 2850001 cccgcagctg ccacgcatga agcggcaaga gtgaccgctg ccagaagaag aatccgtctt 2850061 tccttttcaa cagcggtgcc cagcccggtc gccaattggt ctccgagctg cataatgttc 2850121 aaatagcgtg ccttatataa agtaaacaga agcaagatca caatccaagg gagaatcgcc 2850181 cagatcatat tccagttcgc cccccatatt gagccggata tccaaaccgc ggcttgcata 2850241 aaatcatgag ggtccatctt gagctgaaaa atcagcaaca gggcgttgaa tccggcattc 2850301 acccctatgc cgactaaaat cagccgaatc ggtgtcacgc cttttttcca tgccagaata 2850361 taaatgagaa acgcagcgag gattgctcct gccaaagcac tgaacggcag cataaatgtt 2850421 ccgaaaaagc taagatctga agctgaccct tgaaaaaagt atataaaaag cactacagca 2850481 agtgaaccgc cggcgttaat tccgagaata ccaggctcgg caagttcatt ttgagacacg 2850541 ctttgcaaaa tggctccagc tacggagatc cctgctccaa caagcaaaga aaggatgatc 2850601 cggggcagcc tgaactcaaa taagacaagt tcatcacgcg ccgttccttg gccgaaaaag 2850661 acctgaagcg ttttaagcgg tgcaattttg ataacgccca aattgagact gataaaaaag 2850721 accaccacga taagcaaaaa ggtcacagcc attacaatga gcggtttgtt tgtttttgtt 2850781 ttcattacag ccctctcctt tcacgacgtg ccaaataaaa gaaaaaggga acgccgataa 2850841 gagaagtcag cgcgccgaca ggcgtttcaa agggcgcatt tacgagtctg gccgctatgt 2850901 cagcaaaaac aagcaaaaca gcaccgagca ccgccgagca aggaatgatc caccgataat 2850961 ccacaccgac caaaaaacgg gtaatatgcg gaatgatcag cccgataaat gcaatggtgc 2851021 cggcaatgga aaccgcagct ccggtcagaa ttactacaat aagcatgcca accagtttca 2851081 ccgctgatgt atattgtcca agcccttttg ccagatcgtc accgagactt aacactgtaa 2851141 cagaccgggc gatgaaaaac gcgagcgtta aaccgacagc ccctgcaata agcaaaagct 2851201 ggacccccga ccatttcaca cccgctaccc cgcctgcgta ccaaaagctg atatcctgag 2851261 cgacatcaaa gcggattgca atggcagttg aaatgccggt aaagaaataa gtaactgccg 2851321 tacccgccag agcaagcttt acaggcgtaa gtccgcccct tgaaaacatg cctatgccca 2851381 ttaccgtcga tgcccccagc cccgctcccg caaaggacca tagcacaagc cccattgcag 2851441 aaagtccggg aaaaaaggca aacgcaatcg aaaccgcaaa cgcagagcct gatgtcacac 2851501 ccataatcga aggctctgcc aaagggtttc tcgtcatccc ctgcatgatt gctcccgaca 2851561 ctgccaacaa tgcgcctaca agcgcggcag ccgccgttct cggaagccga agatcatgta 2851621 taatttggtg agatgtcttt gtcggctgat aatgaaaaat ggcctcccat acagtgcgca 2851681 aatgaatatc cgctgcacct agggatatgg ataaaaatgc gccaaggcaa agcaggcata 2851741 gacctgcgat aaggacgatg accgcgccat atgtccttga cgtccattgg atttcttctg 2851801 atgcagtccg tatattttta tgttgactca actgccgtac ttcctttctg ttactgataa 2851861 tgattatcaa ttgctgtttc agtatatcac ttttttcagc tgatttaata gagtgttttg 2851921 aacaaaaatg aaaatgcatt tgcaaaaata tcgtgtcaac cggcacttgc agtggtataa 2851981 tcacagatga taatgattct ctttttcatc tatcttttag aaagaaggta tgagatatga 2852041 cccatatata caagaaactc ggagccgcgt tttttgccct gttattgatt gcagcgctgg 2852101 cagcctgcgg gaataactca gaaagcaaag gttctgcctc tgattcaaaa ggcgcagaaa 2852161 cctttacata caaggctgaa aacggaaatg taaaaatccc gaagcatcct aaacgggtgg 2852221 ttgtcatggc agacggctat tacggctact tcaaaacact cggcatcaac gttgtaggtg 2852281 cgcctgagaa tgtatttaaa aacccttact acaaaggaaa aaccaacggc gtcgaaaaca 2852341 tcggagacgg cacttcggtt gaaaaggtca ttgatttgaa ccctgacctg attatcgtct 2852401 ggacaacaca gggcgctgat attaaaaagc ttgaaaaaat tgcgccgact gtcgcagtaa 2852461 aatacgataa gctcgacaac atcgaacagc tgaaagaatt tgcaaaaatg acgggaactg 2852521 aagataaagc tgaaaaatgg ctggccaagt gggataaaaa agttgcggcc gctaaaacaa 2852581 aaatcaaaaa agcggtcggt gacaaaacca tttccattat gcaaacgaac ggaaaagaca 2852641 tttacgtatt tggtaaagac tttggaagag gcggaagcat catttacaaa gacctcggcc 2852701 tgcaggctac aaagctgaca aaagaaaaag ccattgacca ggggccaggt tatacaagta 2852761 tttcattaga gaagctccct gacttcgccg gagattacat tttcgcgggc ccatggcaat 2852821 caggcggtga tgatggcggc gtttttgaaa gctccatttg gaagaacctg aatgccgtta 2852881 aaaatggcca tgtatacaag atggatccga tcggattcta tttcacagac ccgatttcat 2852941 tagaaggaca actggagttt attacggaaa gcttgactaa ataaacaaaa gagccgcctg 2853001 cccgcggctc ttttgcttat ttataaggaa cggctcaatt tgaatcatat cggatatttt 2853061 ctttgagcca ttcatattaa gctgcatcct catcacgatc agttttttta tgctggagag 2853121 actgaaaaac gttttttgca tatttaacga acggattcct aacaggagaa attgtgattt 2853181 tataaaaaag acacctgagc aaatcaggtg tcttttcatt atgcttgttt ttctttctgg 2853241 aacttgttac tcacaaatgg ataaacgatt aagccgacaa agaataaacc gatgccgagt 2853301 ataaatgtcg ttaaatctgc tgtgcctgtt acgataacaa acacggagta tgcacacgcc 2853361 agtatcgcga tcaatccgtc tcttacacgg gagcctttca gctggtcata cgtttcacct 2853421 ttgatgacta ccttcaagct gtagattgca gataccagat acggaattaa atatgcgagt 2853481 gtagccgctg tcgttaaaaa tgtaaatgcg tcacttattg tccgggaaat aaccgagaaa 2853541 atgaagacct gtgacatgac gtttgtaata atgagtgcaa tgaccggact tcccttttta 2853601 ttcgtttttg caaaaaatgc cgggaaatct cctgctttag cggcttggta tggcacctca 2853661 gagccaagca aaatccagcc gagcatcgtt ccgaataaac aaaggatagc caaaagcgcc 2853721 ataatcacgc ttcccgcgtt tccaacaatc gcatagagta catcaacaaa tggtttttca 2853781 gagccgacaa gcttatcatg cggcagaaca cccatcgtaa ttaaagtcac aataatatat 2853841 atgctcaagg caatcagcaa gccggtaatt gtcgcacgtt tcacatcacg ctgagagcgc 2853901 gcacggccgg acaggatcac cgcggattca attccgacaa acgcccacag tgtagaaatc 2853961 gcagcgttat gaacctggcc accaattcca atgcttgtgc cgttttctcc ttgaaccggg 2854021 aaataaaaat gaccgaataa tgacgtttga aacacaaaca aaccggcaac gataaagaag 2854081 acaaaaccta atactttaga aagcgttgtg acaaagttta atttacttgc gccgttaatg 2854141 ctggcaacaa gaatcgcgtg cgttccccat aacaagatcg tacatacggc aaacgtcagt 2854201 aattggccga gtgtcacctc ttgcccgccg atcgaaaaca tctcacgttt atcaaccaag 2854261 atcgggaaga acgaagtcaa gtaaccggcg agacttgtga tgatcgccac gttactgatc 2854321 cagctcgcca cccagtagcc ccacaccatt gtgaaaccgg cagcgttgcc ttttttcggg 2854381 tcagaaaaca gcgctcttgc ataactttgc ggtcccgctg tcagttcagg cttgcgaatg 2854441 gacaagtgtc cgaacacaag tgcaatcatc agcacgccgg cacctgtcaa aagccaggcg 2854501 gacgtagctc caaacggact cgcaattgaa gcaagcgagc tcggcaagga gaaaattcct 2854561 gatccaacca tatttccaac gacaaacgcc gttaataacc aaaaacccca tttttttgtc 2854621 tgttccattc cagtacctcc atgattcttt gtacggacca gaccccgaga tcatataaac 2854681 gcaaaaaaag cctgaacaaa agtccatgct taaagaaaca cacacccttg atctccggat 2854741 agccctccgc gaaaaagcac gcggcagtcc tgcacttatt cagatacagt cccagcatag 2854801 agaaggatcg gctttctcca cacttcggcg ctgatgcctt ttacacatgt ttaacagccc 2854861 ctgtcagcct agcatgtgtg actcatcatc cgcgcaacct ctacctcact gagaaagagt 2854921 gaggatttaa ttattcagtt actcccagaa ggttatcaaa gaaaggatga tctgtcaaag 2854981 ggaacagatg gaaaatacgg atagagccaa gccctatccg catgtggtta tcgattattt 2855041 ttcttttttt gcacagcttc ttgaagcgga tcatctttta gagctgaacc agcatcttca 2855101 agagctcctt ggattacgtt tttttctttt tcggaacgtt ttcctttatc tttattaaag 2855161 aaacccattc gtatcacctc ttttaaaaaa taggtacatg tttaagatgc ctttttcctg 2855221 aaaaattatg cgggatattt tttatcgtcc aaagtcctgt tgatcaaaca tacattctct 2855281 tgatatattt gtaattcaga gattttttgc aaaagataaa aggagaagcg gcaaatgaca 2855341 ggaaaaacac acatcatggg aggcatcgct tcttgtacgg cagcggctta ttattatgga 2855401 tttgatccag tgcttatggc tgcgtcaggc gcggttggag cattaatacc cgatatctgc 2855461 cacacacaaa gcaaaatcgg gagaaaattt cctattttat cgaaagtggt cagctccgtt 2855521 tttggccatc gcacctttac acacagcctg ctgtttatgc tcatcatgtt ttttatcact 2855581 tctacataca ttccagataa aaacatatca gccggcctga tgatcggaat ggcgagccac 2855641 ttgattcttg acgcttggac ggtgaacgga atcaaattat tattcccttc cacgatccgc 2855701 gttcggcttc cattatatat gaagacaggc agtttttctg agcagctcgt gctagccggc 2855761 ctgacccttg cttcatgtta ctacttttat atgctgtttc atggccgcat gttttaaaca 2855821 tgagtgctga gacttgtctg aaccggctgt ttttagtagg ttttacttaa gaagcatttc 2855881 atgcagatga tcaagaaaac gtgaggagtc atattgatga aaggaacctt ttttcacaat 2855941 cagcggtttt tatgtttttc gatcttattt atgtggatca aaacgtatgt gatatataaa 2856001 ctcggctttg atttgcaaat cgatactctg ttggaggagc taatgctgct ggtcaacccg 2856061 ctcagcttta ttcttccttt attcgggatc ggcctgtttc taaaagaaaa caagcagcgg 2856121 gcctttttgc tgattgccaa tttggttctg actgttatct tgatctctaa tacgattttt 2856181 tacggctttt atatcgattt tattaccatc ccggttttat ttcaggccag caacatgagc 2856241 gatatgggca gcagtgtaaa agaactgttc catcctctgt ttatcgccct gtttgtggat 2856301 ttggtttttc tgctgttgtt cgccagaaaa accaaacacc cacagacaaa agccgctccc 2856361 cacacgatca aacggtacta tgcagcttcc tgcggaatgc ttttatgcac actggcactt 2856421 gcagaagtac agcagccgaa gcttttggca cattcttttg accgggaaat gctagtcaaa 2856481 agcatcggcc tgtttcagtt ccatatttac gatacaattt ctcagactgt taatatcagc 2856541 gcgaaagctt ttgccgatga agacagtata actgccatta aaaactacac agaggctgat 2856601 tacagcaagc ctgatcaaag caaattcggt cttgcaaagg ggcgcaatgt catctttgta 2856661 acacttgagt cgacccaaag ctttgttctg aatgaaaaag taaatggaaa agaaattacc 2856721 ccatttatga atgatctcat aaaaaaaagc tattcctttg atcatttcta tcagcaaaca 2856781 gaacaaggca aaacatcaga ttcagaattt atcgtcgcta actcactgta tccctccctt 2856841 agcggcgccg tctttttcac gaaaagcgac catcaatttc atacgatgta taaatcgctg 2856901 aagcagcacg attattattc agccgtcttt cacgctaacc ataaaacatt ttggaacaga 2856961 gatgtcatgt acgatacatt tggcattgac cgcttttttg atgttgatga ttttcatgtc 2857021 actcccggga catcgacaag ctggggctta aaagacaaag aatttttaga gcagtccgcc 2857081 aaaaagctga aaagcctacc gcagccgttc tacagcagtt ttatcacgtt aacgaatcat 2857141 tttccgtttg agattgatga aaaggatcag ctgatagatg aattcgattc aagcagtgat 2857201 ctgttaaacc gctatgtgac cacggttcgc tatgaggatg aagcattgaa gcattttatc 2857261 aaaaaactga aggacgaagg cttatacgaa aattcgatga tcgtatttat gggagatcat 2857321 tacggcattt ctgaagccca taacgaggca atggctgagt ttttagggaa agacgaaatc 2857381 acaccgtatg acaacgttca gctccagcgg gtgccgttta tcatacatat cccgggaatc 2857441 accgatcaac agccggaaac catccctgat gccgggggac aggtcgacgt caggccgacg 2857501 ctgatgcatt tgctcggcgt tgagacaaaa ggcgatatcc aattcggcaa tgatttgctg 2857561 tcgggcgacc gcaccccatt cgccgttctg cgaaacggca gctttattac gaacgattat 2857621 gtatacacaa agaacacgtg ctatagccaa aaaacaggtg aagtgctgga agatcaggat 2857681 gcgtgcctcc cttacaagga gaaagcaaac gaagaactgt ctctctctga taaaatttta 2857741 aatggtgacc tgctcaggtt ttccgaatga aaaaatccct ctatcaagag ggatttttta 2857801 cgtttccaat atcaccttgc cagtcagctt cgtttcatag ccgtttaaat gagacagatt 2857861 cgccttgtag tcctcagaat tcaaaatctc cttcacggct ttgagcaact gctcattttt 2857921 tttcaaaaca acgatatcat attgttcgtc gatgagcggg ataaaatcaa cactgcccat 2857981 atgtgccgcg tgctgtgccc cgattcccgc gtcagcctgt ccgcttgaaa cttgtgaagc 2858041 ggcagcgtaa tgatcagtca cgatatcgcc atatcccact acatcagccg gattcacacc 2858101 aagcaagcca agctgttcat caaggagcac ccttgcgcca gaaccctttt ccctgttgat 2858161 gatccggata tcggctcttt tcaagtcttt ccagccttga atgtttttcg gattcccttt 2858221 ttgcacatac agtcctgctt tgcggagaac gacattgatg agacaaaacg gttcacctgt 2858281 caaaatccgt tttacataag gcgcgttata ctggcccgtt tctgcatcgt acaaatggag 2858341 gctgacaatg tcacacttgc cttgatacat atcaatcagg ctgtttaagc ttcctttgta 2858401 tttacggagc ggcgtctcct gaatggcatt ctccaaatgc ttgctgagga tatccatcga 2858461 aatgtcctgt ccgctgatca tgacatttgg tctgccgtcc ggctcagcct cctgcacctg 2858521 tttcggcgct tcttttgcag cgatgggctg agacattctc atattcgttt tatattgctt 2858581 taaatcttct tcatccacac gcatctgcct tccgacacgg taagcaggca gcacgccttt 2858641 tttaatcaag tcataaacgg tcagctttga taccttcagc agacctgcaa cttcttctat 2858701 cgtataggaa gaggtttcat tcatcatcat cactctccta ttttattata ccttttcgcc 2858761 gaatgtaaaa aaacccacat aaaccaaaca taatcagtta taattagtta tatctaatga 2858821 taaggggtgc aatcatgttt aagaagtatt ctattttcat cgcagcctta actgcttttc 2858881 tgcttgtagc aggctgttct tcaaaccagt cttcaacgga cagcgagaaa aaagtaacgt 2858941 taaccatctc agctgccgcc agcgcgcagg atgcacttga ggaaatccaa aaaaattatg 2859001 aaaaagatca tcaacatata accatccaag ataactatgg ctcatccggc gccttgcaaa 2859061 aacagatttc tcaaggagca ggagcagatc tgttcttctc agctgctgag gataaattta 2859121 aaaagctggt ggatgatgga gatatcgcaa aaaaagacag cactgaatta gtcggtaatg 2859181 aaattgtgct ggtcgtaccg aaaaacggag attcacctgt gacaagcttc agcaatctgg 2859241 ctgaatcaga aaaaatcgct cttggcactc cggaatccgt accggcagga gcttatggga 2859301 aagaatcact gacaaagctg tctttatggg acaaagtgaa ggataaaatt gtgtatggaa 2859361 aagacgttcg ccaagttctt tcttatgttg aaaccggcaa tgtagacgca ggtgttgttt 2859421 ataaaacaga tgccctagtc tcgaaaaagg tcaacattgt tgacgaggca aaagcagata 2859481 cacacagccc aattgtctat ccgttaggaa tcgtaaaaga tacaaaacac cgtaaggaag 2859541 cgaaggaatt ttacgaatac ctgcaatctg atgaagcaat gaaagtattt gagaaatatg 2859601 gctttactgc cgagtagcat aagcgcttca gaatttttca cacccgttgt gctttccttt 2859661 caggtggcgg cagttgccgg aattgttgtc attattctcg gaacacttgc tggagcatgg 2859721 atgtcacggg catcattttt cggaaaaacg gcactcgaaa catgttttat gcttccgctc 2859781 gttcttccgc ctactgttgt cggttttatt ctgatcgtca ttttcggaaa gcacagcttc 2859841 atcggacaag ccatcgagtg gattttccag cagcctgtca ttttcacctg gtgggccgct 2859901 gtgatcgcct cggctgttgt agcctttccg cttatgtatc aatcagccaa aaccggattt 2859961 gctgacattg atcccgatat acaaggtgcg gcaatggtag acggcgctag cagatggaaa 2860021 gtgtttatcc atatctccgt cccgcttgcc tatccttcgt tactgaccgg aagcatcctt 2860081 agccttgcgc gggcgctcgg agaatttggc gcaacactca tgtttgcagg aaacatcccc 2860141 ggtgttacgc aaacactgcc gacggcgata tatgtcgcat tggattccgg caacaatacc 2860201 cttgcttggg cgtgggtcgt ctgtattgtt gtcatttcct ttttgatgct gtttttcatt 2860261 caacagaaaa aaacgcacta aaaaaactcc ccataacggg gagttttttg attaaaacag 2860321 aagctcatca ggatttggac cgacacgctc atctttattt aatgcgtcaa ttttgtccat 2860381 gtcttcttga gacaattcga aatcaaaaat atcagcgttt tcgatgatac ggtgttcttt 2860441 aatggatttt ggaatggtta caactccatg ctgcagatcc cagcgcaaaa tcacttgagc 2860501 cacagattta ttgtgttttt cagcaatctg tgtcagtact tcgttatcca aaagctgtcc 2860561 ctgcatgagc ggagaccacg cttccagctg aatgccttgc cctttgcagt aatctcttaa 2860621 ttctttttgc gtcaagcgag ggtgaaattc aacttggttc accatcggtt tgatttcagc 2860681 atctttcaac agctcttcta aatgatgaac ttggaaattg ctgacgccga tcgcgcgaat 2860741 tttgccgtct ttgtacagct tttcaagcgc gcgccatgta tctttatatt tatctttgcc 2860801 aggccaatgg atcaaatata aatctaagta atcaagctgc agtctttcta ggcttttttc 2860861 aaaggcagca agcgttgttt catagccttg atcttcattc cacacttttg atgtgatgaa 2860921 gagctcttct cttgccacac cggattcttt aatcccgatg ccaacgcctt cttcattttt 2860981 gtagatcgct gctgtatcaa tactgcgata gccattttta attgccgctt tcactgattc 2861041 agtcgcttca ttaccatttt ctactttaaa aacgcccaga ccgaaccaag gcatttcaac 2861101 tccgttatgt aactttacag tatcttttaa acttgttggc acttgaacct ccaccctttc 2861161 actgaaatgt aagcgtctat attatctcac attcctctca gccgatacca ataatacgct 2861221 taagaccctc tttttgcttc ttttttcaca gcacaggcaa atccaaacac tatttttttc 2861281 ctattttaac aatattgaga ttacaaatac attgagcagg gtatgcgtgt agtgtaacca 2861341 aatgaaaaca aaggaggaaa caacttgaaa cgtattcgta tcccaatgac acttgctctt 2861401 ggtgccgctt tgacaattgc ccctttgtcc tttgcttccg ctgaagaaaa tcctgctccg 2861461 aagatgtcgc agacaactac tgctggaaca actgccgctg atgtaggttt aaacgtcaac 2861521 ctggatgtac ttggaattgc caaccagatc gctgatgcca tcaaatccgc acagaatagg 2861581 gatggctttg tgaaaaacct catggagtct tccttctacg cgtccggcca aaaatataac 2861641 gtcatggtct ttaatttaag ccaggaatat gaagatcatt tgaacggtgt gcaattttac 2861701 ggctcagccg tttacgacgg cattacgtat ggcatttggg tatttgaaga tggaaccttt 2861761 acaaacaaag gcgatggcgg ctggatcaac tgggccttca gaggctggtt cgaccgggat 2861821 ggcagcactg tcgcatttca tcgcccttaa tataaaaaaa gctggcgctc taacgccagc 2861881 tttttttctg catttattcg ccgccttcaa gcatggcggc ttcgacatca ttaatgtatt 2861941 ggcgaagctc atgggagatg tcccgggaaa tttccctctc ttcgaagagc gtttgaattt 2862001 catttctgat cgcctgcaca gccttcagct tcacttccag cttctgattt tcaaaatggg 2862061 cacttgattt taactcatga tggctgtgct ccagcctgaa aattaactgc ttatagaatg 2862121 taatgacaga taaaaacact tctttatgct catccgtctt atgtttttcc agatattcta 2862181 tcgctgcttt tgccgttttc actcttgttg cccgtatcaa tcccgcttca tttaaaatcg 2862241 acatctccgg ctttttatgt tcaccgaaga aaatccaata catcagcctc ttgagccttg 2862301 tttttgataa cccgacttta aacgggttgg catacaaaat ttccaactcg ttaaatcgtt 2862361 cttgcagcac atttgctgtt tcttccggga tgtctccccg ctccagcatt ttcatcagcg 2862421 cctcttgctc agccttaacc ccctgcgcac ggacttttcg ctcgtgcttc ttaatgcgat 2862481 tagatgatgt atactgctga aaacgaagat ttttcatttt ctcattgtat tcagctatca 2862541 ccgcaagaga ggccgttttg tttgtctcat tcatgtcctc tttaatcgtt tgaagggctg 2862601 ttttgatcaa cttgcgtctc gccgtcagca gcttcttatt tcgttcctcg tcctcttctt 2862661 ctttttcagt cagaattggc agcacaacgg tggcaatgac aagcgtgcat aaaatgacgc 2862721 cggctgctaa aaagagaatc agatttcttt ccggaaacgg cgtaccgtcc tccaggaaat 2862781 acggaatgga aaaagaacct gcaagcgtta ctgctccacg cacaccggaa atcgaaatta 2862841 acagcgtcga acgaagaccc ggtttataga tgttctgatc tttattaaag aaccatttgc 2862901 cgttccagaa gaacagcacc cacaggaatc taaggagcat taatgtaaat gtgatgacta 2862961 ggatatagcc gatcaccttc atgttgctga tggcagtgtc gttaaagata acagaaataa 2863021 catcagggat ttgcgtgccg agaataacga agaccaggcc gttcaaaata aataaaataa 2863081 tgttccacgt acttgaggag acgatttgca gcttgatcat cgttgattcc agacgatcct 2863141 gttcaaccgc atgggtaata ccgccagcta caacagctaa aatgcccgaa acgccgattt 2863201 cttcagctgc caaataaatc acaaacggcg tcagaatttg aatcagcata tgcatcgtga 2863261 catcctgcat gccaaggcgg cgcagaaata ggcgaaaacg aataatcaaa aatgaaatga 2863321 caaccccgca cagcaagcct ccgagagaaa taaagacaaa gctgacagcc gcttgtgcta 2863381 atgaaaatgc accagtcact gccgctgcaa tcgcaaactt aaaggccacc agacctgatg 2863441 catcattcat cagcccctca ccttccagca ggcgaagaat cccttttggc attttcactc 2863501 ttcctgataa tgcgctgaca gcgacgacat cagtcggtga aagaatggcc gcaagtccaa 2863561 aggccgctgc cagcggaata gcaggaatca tccagtgaat cgtgtagccg cctacaatca 2863621 cagtcgcaaa tacaaggccg agtgcaagca ataaaatcgg agcccttaaa ttccaaagct 2863681 ctgcccgcgg tgtcctcttt ccatcattaa atagcagagg cgcgataaaa agaacaaaaa 2863741 acaattcggt gtttaattca aaatgaagtc cctgtggaaa tgaggcggca agaatcccaa 2863801 gagccacttg aatcagcggc accggaataa acggaataaa ccggttcacg atattagaaa 2863861 tcgcaataat cgttaataat acgagcacaa ctaaaaatat gtccaaatgc atgacctcct 2863921 tcgtctgttg tgtgtcggca tgatgagcca aaaaatctgt ttgtctaaaa gcccttgagc 2863981 tagggtggcc ttgcatccgc tatgtggttt cgcaggagtt ctctccacac ttgtcttctt 2864041 ttatagtacc ctttttaggg tattttttct catgatatgc tcacagtgaa cttttttgca 2864101 gaagagcaaa ttatagaaaa aagagacagg aagctactcc ctgtctctcg tctttctttc 2864161 tcaatcatga aaattcgtac cgtcagttgt tgctttaata atgcccgcgc gaatgacaaa 2864221 gtcaccgaaa tgctcgcctt cctcgcgttc tttcgcatag cgggaaagaa ggatgcgcag 2864281 ctcgcttaaa atgtctgctt caccgatgtt ttcacggtac attttgctta aacggcttcc 2864341 gtcaaacgca gcgccaagat acatattata tttgcccggc gcctttccga taaatccgat 2864401 ctcaccgagt gcatgacgtg cacagccgtt cgggcatcct gtcatgcgaa tggtgatttc 2864461 ctgatcacga aggccgtttt cgtcaataat ctcttcaatc ttatctaaca gggtcggcaa 2864521 ataacgttct gcttcagcca ttgccaatcc gcaggtcgga agagcgacgc acgccatcga 2864581 gctgcggcga agcgctgaat agtgcttgcc gtcagttagt ccgtactgtt caattaaagc 2864641 actgatttct tcttttttat cgcttgaaac gttcgcaatc attaagttct gattggctgt 2864701 cagccggaac tcacctgtat gaactttggc gatttcccgc aagccagtca tcagcttata 2864761 atcatcgtaa tccgttatac ggccgccttc gacaaacagc gtgaaatgcc atttatcctc 2864821 gatgccttcc acccagccat agcggtcgcc gttatgatcg aaatgatacg gcttcgcttc 2864881 ttccaggctc cagccgagac ggttttccaa ttcttctttt acgttttcta aaccgaggcg 2864941 gtcaactgtg tatttgaacc gcgcattttt acggacagaa cggttgccgt aatcacgctg 2865001 aatcgtaatc gttttttcag caacgtcata catttgctca ggccggcaga aaccgatcac 2865061 cttggctaat tgcggatatg tcgcagtatc gccatgcgtc attcccatac cgccgccgat 2865121 tgccacgtta aaaccgatca gcttgccatc ctcgacaatc gcaatgaatc cgagatcttg 2865181 tgaaaagacg tcaatatcat tagacggcgg aacggcaata ccgattttaa acttccgcgg 2865241 cagatagagc ggtccgtaca ttggctcgac ttcttcctcc ggcgtgccgg caactctttc 2865301 ctcatcaagc caaatttcat gatatgctct cgtccgcggc agcagatcat cacttaattt 2865361 tttagaccac tcgtatacct ctgagtggat ttcagattga taagggtttg atgcacacat 2865421 gacgttacgg tttacgtctc cgcaggctgc gatcgtatcc aaaagtgctg agtggatcgt 2865481 ctgaatggtt ttcttcatgt tccatttcag aattccgtgc atttggaatg tttcacgtgt 2865541 cgtcaatttt aatgtgccgt tcccgtattt ctgggacagg tcatccatga caagccattg 2865601 ttcaggcgtc gagacgcccc ctggcatacg cacgcgcagc atgaactgat atgcgggctc 2865661 aagcttctgc ttttggcgtt catttcggag gtcgcggtca tcctgcaaat aactgccgtg 2865721 gtgtttcatc aggcggttat catcatccgg aattcccgca ctgattcgat cgagcatcac 2865781 ttctttcagc gtgccgcgca aataatcact ttctttttta atgcgttcaa catcacttgg 2865841 agagccgtcc ggtgctttta gaattttggt caccatgttg aaaaactcct ttcaagtcaa 2865901 atcaatatac atcacgctga tagcgttttt gctgctgcat atcggcaaga taagcctccg 2865961 cctcttcgcg gctcatattg ccttcttttt cgataatttc aagcaatgtg ttatggacgt 2866021 catgcgccat gtgcttttca tctccgcaaa tgtaaacagc cgctccttct tgaagccatt 2866081 caaacaattc tgcgctatgt tcaagcatgc ggtgctgcac atatactttt tcttccgtat 2866141 cacgtgagaa cgccacatcc atttttgtca gcacaccgtc tttgagccaa ttctgccact 2866201 ctgtctggta aaggaaatcc gtgacaaagt gctgatcgcc aaagaacatc catgcctttc 2866261 cttccgctcc cgtctcctca cgctcctgca taaacgaacg gaaaggtgcg acgcctgtcc 2866321 cagggcccac catgataatc ggtgtttcag ggtctttcgg aagcttaaag ttttgattgt 2866381 gctgtacata aaccggcagt gtgtctcccg gctgcagtcg ttccgcgcac aaaatcgagc 2866441 agacgccttt tcgttcacgg ccgtgcgcat cgtagcggac tgcgccgatt gttaagtgca 2866501 cttcatccgg atttgcggat aaactgcttg caatcgaata aaggcgggca ggcatttttc 2866561 gcaaaatcga gacaaactcc tgcgcagata cactaaatgg gccatagtca cggacgagat 2866621 caagcaaatc gcgcccttca atataggctt ttacattctc ctcatttccc ggggctaaaa 2866681 gctctctaag ctcatcgttc cctgtcagct gggctgcctg ttcaagaagc ggttttgtga 2866741 gaacggtaat ctcatagtga gaaatcagcg cttctttcag cggtcggaca tcaccttgct 2866801 tattaagcgt cacaatttct tccgggtccc aattcatttc cttaaggagc agctcgacaa 2866861 gttccggatc gttttccgga tagacgccga ggctgtcacc aggctcgtaa gtcaggccag 2866921 atccttcaag agacagctcc acatggcgtg tttctttatt tgatcctctg ccgtttaaat 2866981 ttaaattttc taacacttca gcccgaaacg ggtttgttct ggaatacgaa gactcaccgg 2867041 tttgtgacgc agccgccggc gcaggcgcgg cgcttccgcc cccagcttca tttaatcctt 2867101 tcaatacacc ctcaagccat tcggctgccg gttcatcata gtcaagatcg caatcaacgc 2867161 gcggagaaat ccgttttccg ccgagttctt ctaagcgttg atcaaattct ttccctgtct 2867221 ggcagaaaaa ttcgtacgaa ctgtcaccaa gcgccaaaac ggaaaagcgc aggtcttcaa 2867281 gcttaggcgc ccgtcttccg tgcagaaatt catgaaacga cagcgcgtta tcaggcggct 2867341 cgccttctcc atgcgtactg acgacgatta aaagattggt taccttcttc agctgattcg 2867401 gcttaaaatc gctcatggat gagacggtca cttgaaaacc gctctgttca agctgcttgc 2867461 cggcattttc tgcaagcccc tgtgcgtttc ccgtctgtga accataaaga acggtcactt 2867521 cttttgaaac ggccggtgcc ggtgcttccg ctgacacagc tgccgccggc gtacccgcag 2867581 cttcttgggc ggaaacagat tgagcggata aatatccgct cagccagatt ttctgggatt 2867641 cggtcaaggt cggcagaagg cggttaagga gctctgcctg ctcctgatta aacggactgt 2867701 tcattacctg aagttgcaac gtatccacct cacaaagtta taaactgatc gaaaattgca 2867761 tctaattgaa ctttaccgga atactaggct taagtaaaat atatttacat gatgataact 2867821 attaagaatc ctaatgataa aacggctatg cttcatgtaa atagaaaaaa gagaaggact 2867881 cccttctctt cattcagcaa tctgatataa gtgaggcggc acagcggtta caaacggact 2867941 ggcttcacct gtataaaata ccgccagcat gtgcatcgca cgggtgcacg cagtatataa 2868001 aagcctgcgg tcgtgctctg tatgatagtg ttcttcagat gcatcataga caagcactgc 2868061 gtcaaattca attcccttcg ctaaatacac cggaatcacg caaacaccct tttgaaatgg 2868121 ttgattttct ttatgaatca ggcgaacatc tgtatattca ctcatgtggg cgtgcgcctg 2868181 tatgcattga tgcgcagtct tgcagatgac ggctattgtt tcgtgccctt ttttcttgag 2868241 ccggccaatt tcttgcgcga gcttttggca aaggctctca tgtccttcag ttttgacaac 2868301 gagcggcatt tccccgcttc tattaaacgg ctcaatatcc gctccatctt gaagcatcgc 2868361 tttggtaaac tcgacaatct gccttgttga tctgtatgtt ctctttaaac gaacatactc 2868421 agcaggctca tcctcaaagc acgcatccat acgctgatcc ccgtttatgg tatgcgcgta 2868481 gatggactga ttgatatcac cgagcactgt catgctggca gccggaaaaa tgcttctcat 2868541 gtaagccatc tgaaacggtg aatagtcctg ggcttcgtca ataaatagat gtttgatttt 2868601 cgtatttttc tttctgccct caatcagatc ctgcatataa agaaacggtg ccgcgtcctc 2868661 atagagcaat ttattatccg taaatgccga acgggtcagc tcacctatcg catccatctt 2868721 ctcatgttga aattttcctc cccagccaga aaacaattgc aaataaagtt gtgtaacatc 2868781 aagaaatgca aggagcctga ctgcctgttt gagcggtttg aaagcttttt tcacaatgat 2868841 ggcggcaagc agctgctgct ctctttgata atcgttaaac gtactctcgc tgaaccgttt 2868901 cctttcctgc agttttttgt acacgtccaa gtagtcctct ttgtcaagca gctcagcttc 2868961 atgaacaacc caatcctttc gccgttcctt tttctcaagc ttgttaagct cactcagcag 2869021 ccacttcgcg gtttgctcca tccgattcgg aatggagtga ttttgatcca atgagtaaaa 2869081 ataggattga atttgctcct ttgtgatcag cttttgtccg cggaatataa tatttttaaa 2869141 aatcatccct tcagaggaaa gccgtgtgac gtattcatta atgaattgct gaaaggataa 2869201 acccgccttc catgtgattc ctgcaagcct tgttggaaaa tcgcctccct ttgtttcggt 2869261 caggcaatat tcgagctgat caaaggggct ttcacatttg aacttgcggc caagacgatg 2869321 ctcgatatat tcctgaaacg tcgcctgctc catattctct tctcctaact ccggcaaaac 2869381 agaggagaca tagctgttaa ataagaagtt gggtgaaaac aaaacgattt gtccggcatc 2869441 aatgacaccg cggtgcctgt ataacaaata agcgacacgc tgaagcgcag ccgatgtttt 2869501 cccgctgcca gccgctccct gcacgatcag gatcttgctt ttttcattac ggataatctg 2869561 attttgttct ttctgaatcg tagacacgat gtttttcatt tgggtatcag agtgatggct 2869621 taatacctct tgcagcattt catcgccaat cgtcatatcg gtattaaaca tcgccttgag 2869681 agtgccgttt ttgatcataa actggcgttt cagcaccatt tccccttcta tcgtttcacc 2869741 gggcacctcg tactccgctt ttcctgggga ataattgtag tacaaacttg atatcggcgc 2869801 cctccagtca tagatcagaa agtgttcctc cttctcatcc aaacaggaag ctaaaccgat 2869861 ataaattcgc tctgcctgct cctcgccgtt ttcaataaaa tcaatccggc cgaaataagg 2869921 cgattttttc aattgatgaa ttcgtttgag ctgctgatcc atgcgccgat gattgtgttc 2869981 ccgatcagac agcagctctg cctgctgctt aatgctagcc atcgtttcaa tcgcttcatg 2870041 ggcatcatca aaattaacct taacatcctc ccaaaagctt tttcttaatc cgatgatatc 2870101 atgcttcaac ccgcccgcag acgtttccag aaaccgctct tttttttcga gctccttcag 2870161 cacctcatct attctcgact gctcttcctt ccattcctta tcctgctgat tcatgaacgg 2870221 cacctccaga aaatagttga caaacataga tgaaatactg taaaatataa ttggatacat 2870281 atattaaata tatgatgcaa actggcaaat acaatttata atagcacatt cacccaatac 2870341 caatcaaggt ttgggttatt tatattatgc agaaaaaaac cgatttcact tcgaaatcgg 2870401 tttttttgct attaattatc taagcgaaaa gaacggtttg gcagcttcca attaaacata 2870461 taggaacaaa cccggcaaac aacgagcacg aaaaacagaa cgtataagcc gaacgagttc 2870521 cccagccagc ccaagccgac gattaaaccg ccgagcgccg cccataccgc atagatttcc 2870581 gctttcagca caagcggttt gcgcccggca agaaggtcgc ggatgatccc gcccccgctt 2870641 cccgtcagca ccgcagccac gatcacggca ctaagcggat ggcccatttt gacggcatac 2870701 agtgcgcctt ggatagcaaa ggcagcgagg ccgatcgcat ctgataaatt gccccactta 2870761 ttccaatgct tcagcagcag cttcggaaac agaaacacaa ttgtaataga taaaagcgcg 2870821 atttgaaagt acgctccctg ctcccatagc gctgacaccg gaacaccgat cagcaaattg 2870881 cggatcgctc ctcctccaaa agctgtgaca atccctaata tataaactcc taaaatatca 2870941 tattcctctt ccatcgcaac aattgcgccg ctgactgcaa acgcaatgat gccaatcaca 2871001 ctaagcagct cccaagccat tctgatgact cccttttatg tttgttaaat tttctgacga 2871061 cctctagatt ttataatcgc tccagcgtaa aatcaataac attttcatga gaaaaaaaga 2871121 taaatttaga gggaatacgg ctattgctga tggacatgag tttgcgaaat taaaaaagcg 2871181 cccggcatac gcgggcgctt tttttgttat tcagattttt cgcctttcag caggcacata 2871241 aaaatgataa tcaggataaa agcaatcagg gccaggaatg gaatcgtaat aaaaccaaac 2871301 cagttaatat attggcccga gcacggcacg ccgctgacac atggcttaat gccgctaaag 2871361 ccgggcactt tttgctctaa gtaatgcatg atcgaaatga atgccccaat aatcgccatc 2871421 gggagcacat attttttcac tcgtgtgtcc ccttgaaagg tggcgatgcc taaaatcagg 2871481 acgagcggat acatgaggat acgctggtac cagcacagtt cacatggaat aaactttctg 2871541 atttcactga aatacaggct gcccagcata gcgataagag ccacaaccca ggaagcatat 2871601 aaaaatacga ttctattttt catattgtta cttccctttc agctcttttt ctattgtctc 2871661 tttgatttca tcataatccg caaaattttt gatcacttta tcattgacgt aaatcgtcgg 2871721 tgttgcctgt atgttcattt tttgattaag gtcagaatcc ttttccactt gagaagcgaa 2871781 tgtttcctta tcaagatttt ccttgagcgt ctcaggtttt atctttgtgg tgctttttgc 2871841 aagatcacca aggaggcctg gggttaccca ttcctgttcc gtatccggct gtttttcgaa 2871901 cagcttttca tggaaatccc agaaagagtc agggtcttcc ttccatactt cttcagatgc 2871961 aagagccgct aaccttgaac cttttccatg gaacatgacg ttcacgaaag aaaatttcac 2872021 atcgccctta tcaataaagt ctttttgtat ttttggaaag atgtcactgt taaacacctt 2872081 gcaagacgga catttgtaat ctccgaattc tactacagtt accggtgcat cgtccttgcc 2872141 aagcacaggc tgccctttga tagacggctg tccggacacc gcatcattgc cttgttccgt 2872201 tttgttatta atgatgacaa tggctgctag caatacaaca accacaaccg taaggatgac 2872261 cgcgaatttc gcagaagact gctgtttctt tttcactccg acacctcatc gttttaaaat 2872321 taaaaaagaa gcggatcgca attgacccac ttctttattt taacaagaca agcgctgata 2872381 agaaaacccc gaaaaaatga attctctccg acaatttatt tgtttttgag acgcatgacg 2872441 cgcatggcgt tcgccacagc aagcagtgta acgccgacat ctgagaaaac cgcttcccac 2872501 atggtcgcaa ttccaaatgc accaagaatg agaaagatcg ctttcacacc taaagcaaag 2872561 ccgatgtttt gccacacgat tcgccgtgtc cgtttcgcaa tccgaatcgc ttctgctatt 2872621 tttgacggct gatctgtcat cagcacgatg tctgcggctt ctaccgcggc gtctgagcca 2872681 aggcctccca tcgcaacccc tatatctgcg cgtgcaagca ccggcgtatc attgatgccg 2872741 tcaccgacaa aaatgagttt ttcactaggc aaaagcttag cttctaatgc ttcgacctgc 2872801 gcgactttat cttgcggcag cagctctgca tatacctcac caatcccaag ctgttttccg 2872861 acggcttctc ccgtttgttt cgaatcaccc gtcagcatag ctgtctgttt gatcccaagc 2872921 gacttcagat cagcaaccgc ctgtgctgcg tcttccttta tctcatccgc tatgatgatt 2872981 gctccggcat agcgttgatc tacagcaacg tgtacgattg ttccagcatt ttcatccggg 2873041 acatcctcaa tttgttctct ttccatgagc tttttattcc cagcaaggat ctcagttcca 2873101 tttacctttg caaaaatgcc gtgaccggag atttcttcgt atgactcaat ctcatcggag 2873161 gaaagcattt tcccgtaagc tttacgcaca gattcagcaa tcggatgctg tgaatgaagc 2873221 tcagcgtatg ccgccgcttc aagtaatcta tcctttgtaa aaccttccgc gggtttgatt 2873281 tctgtcactt caaagctgcc ttttgttagt gttcccgttt tatcaaacac cgcgtatttg 2873341 acttgattca aagcttctaa ataattgctt ccctttacaa gcactccggc ctttgaggcc 2873401 gctccgattc caccgaagaa accgagcgga atagagacaa caagcgcaca aggacaagaa 2873461 atcactaaaa agataagcgc gcggtacacc caatcggaaa gcgcggcgcc agaaagaaca 2873521 agcggcggaa caaaggccag caataccgca atgatcacca cagcaggtgt ataatacttg 2873581 gcaaacttcg tgataaagtt ttctgtccgg gctttacggc tgctcgcatt ctgaaccaag 2873641 tctaatattt ttgatactgc tgattcctga tagccctttg tgacttcaat atgcagaacg 2873701 ccgttttgat tgataaagcc tgacattaca tcttgtcctt ccgcagcttt tctcggaacg 2873761 gactcacctg ttaaagcaga tgtatcaacc atcgctgacc cttgcacgac cttaccgtcc 2873821 aggggtatgc tttctcccgg attaaccaca atgatgtctc ctgtctgaac gtcctccgac 2873881 gaaacctgtt cgatgccgtt ctttgttttg agattggcgt aatcaggccg tatgtccatt 2873941 aacgcactaa ttgattttct ggaacggctg accgcggctc cttgaaaaag ctcaccgatt 2874001 tgataaaaca gcataacggc gaccccctca gggtattgct gaatcagaaa agcgccgatt 2874061 gtggcaagag ccattaagaa atgctcatca aacacctgac cgcggatgat gtttttgact 2874121 gcgcggatta taatgtcacc gccgataatc aaataagcac cgaggaaaag gaaaaattca 2874181 atggttcccg actgaaccaa atatgccgct gcgccgagaa tgacagccgc cgccattctg 2874241 atcagcatat tgaccattcg attacgatag ccatcatcag ctgatttctt tatatgcttt 2874301 tggcgaaccg ttacatgcgg atcaattgat ttcacttttt tctctacttt attcgtgacc 2874361 cattgctctt ctttcccatc ggctgagaca gttaaggtgc ttgccgcaaa atttaccgcg 2874421 catccgttaa tgccttttat gcctttgact ccattttcga tttttcgggc acaattgctg 2874481 caatccaaac cgtccagaac atattcctgt ttcactagtc tcaccttacc ttccgattta 2874541 gggttccctc ttcaaagcgt atcaatgagt attgtattta ttttatatat atgagcatat 2874601 actcatatat aagttacacc tattatatgt tgttttccaa gaaagtgtca atgaaaaaca 2874661 aaaaccggca tatagccggt ttttcatttt actttttgca gacgaagagc attcagaaca 2874721 acggaaacgg agctgaatgc cattgctgct cctgctatcc acggtgctaa aaatccaagt 2874781 gctgcgattg ggatgccgag gctgttatag ccaagcgccc agaataagtt ttgtttaatg 2874841 tttttcattg tcaatctgct catgcggatt gcgtcggcaa tgctgttcag atcgccgcga 2874901 ataagtgtaa tgtctgctgt ttccatggca atgtccgtgc cagttccaat cgccatgccg 2874961 atgtcagctg tggcaagcgc cggcgcatcg ttaattccgt cgcctaccat tgctgtctgg 2875021 cggccttctt tttgcaagcg ggcgatttcc gccgcctttt gttcaggaag aacttccgca 2875081 atgatattcg caattcccgc ttccttcgcg atggcttctg cggttctgcg attgtctcct 2875141 gtcatcatga tgacatcaag acccaactct ttcagacggg caacagcctt ccgcgacgta 2875201 tccttaatcg tatctgcaac tgctactagc cccgctgctt ctccatcaat ggatacaagc 2875261 ataactgttt tcccttcggc ctctagctct tccatttggg cgagaagagc cccatgctca 2875321 acctgttcgc tctccattaa ttttcttgtg ccgacgagaa tgctttttcc tccggcttca 2875381 gccaaaatgc ctgcgccgac ttttgcttca aagcgggtaa gtttcggtat ctcaagccct 2875441 ttatctttca cgccagcaat aatcgcttcg ccaagcggat gctctgatcc cgtttccgct 2875501 gccgctgcaa attgaagcaa atctttttct tcaaaacggc cgaatggaat ggcatccgtc 2875561 agacgcggct tcccgtttgt cacggttccg gttttatcaa gaacaattgt atcgagacga 2875621 tgtgtttttt ctaaatgctc gccgccttta aataaaatcc cgaattcagc agcgcgtcca 2875681 gatccagcca ttatgctcgt cggagtggca agaccgaggg cgcaaggaca ggcaatgaca 2875741 agaaccgcaa tgaacttgct gatcgcttcg gcaaaatcgc caggagccgc ccaaagatac 2875801 caaatgagaa aagtgagaac cgcaatcccc aatacaatgg gtacaaaaat gcctgaaatc 2875861 tggtcagcga gacgctggat cggcgctttt gacccttgtg cttcctcaac aattttgatg 2875921 atatgagaaa gcgcagtatc ctttccgacg ttgacagctt taattttcag aaagccgttt 2875981 gcgttaacgg ttgaacctgt cacgctgtca ccaggatttt tgtcaacagg aagactttct 2876041 cctgtaatca tcgattcgtc aaccgctgaa cggccttcaa ccacttctcc gtcgacagga 2876101 attcgttcgc caggtttgac gtaaacaatg tcattaacaa gcacttcgtc gatcgggatg 2876161 atttgctcct gtccgtctct tacaacagta gctgttttcg cttgaagctt catcagcttt 2876221 ttaatcgcat ccgaggaacg gccttttgct tttgtttcaa acaacttgcc taataaaatc 2876281 agcgtcagca aaatcgcgct tgtttcataa taaaggccgt ctgtatgccc gtgagagcca 2876341 atgctttgaa aagttagata aagactataa gcgtaagcag ccgtcgtacc gagggcgacc 2876401 aatacatcca tattggcgct tttatttcta agcgccttat acgcacccac ataaaacggc 2876461 cagccgatca gaaactggac tggtgtcgcc agcgcaaact gcatccacgg attgagaaat 2876521 atatccggta cccaaatgaa tgatgtaaat gtaaaatggc tcaccatcgc ccaaagcaat 2876581 ggaaatgaca ggacagctga aaaaatcagt ctcgccgttt gcttccgttc ttctttcttt 2876641 ttagcagcag cctcactgtc ctgttcaccc ttcaacttta gcttatatcc aagcttatct 2876701 accgcttctt tcaaatcgct gacagacgct tcttttggat tgtattcgac cgtaactgtt 2876761 tctaaagcga agtttactgg tgcatttgcg acgccttcta ttttgttaag ccgtttttca 2876821 atccgattgg cgcaagccgc acaggtcatg ccctcaatat cgaattcagc tttttctgta 2876881 acgacgtgat agcccagctt ctctattttt tcctgaatcg ctgcagtccc tgtttcagca 2876941 ggatcgtaga ttacatttga tgtttccgtt gccagattaa catttgcatc cgtgacaccg 2877001 ggcatccgct tcaggccttt ttcaattctg gcagcacatg ccgcacaggt cataccagag 2877061 acctgcatcg cgatttcctt ttgttcactc aacatactca ctcctttata tacacctggg 2877121 gggtatataa aaatgaaaga aatatcgcgc ctccctaaag gcgcgatacc ttgaatcact 2877181 tggctacgtc atagccctga tcttctatcg catccgcaat atctttgact gatactttgt 2877241 cagcatcaaa cgaaacatcg actttacccg cttccagatt gacatgaacg gcactgacgc 2877301 cgtccagttc tcctacgctt gtttctactg ctttgacgca gtgctgacaa gacattcctt 2877361 caacttgcaa tgttttttgt tccatatcaa ttcctcctgt ttattctttc tattttcatc 2877421 ctaccatacc cccgtagggt attacaataa aaaacgcttt atgattttgt gaacttttta 2877481 aatacgtcca aaagctcaga aatggcctgt tccccgtctc cgcttttgat ggcatctgct 2877541 acacaatgat gggcatgatc ctcaagcaaa tgaagcgcca catttttcat tgccgcctga 2877601 acagctgaaa tttgcacaag aatatctaca caatatctgt cgttttccac catgttttga 2877661 atgcctctga cctggccctc aatccgctta agccggtttg taatctgatc cttttctttc 2877721 gagcttttat ggtttaatgt tttatgttcg ttatgctttt ccatgcgtac acctctgttt 2877781 aatgatatta attcccatta tactgattgt ccaaacggtt gtctaagcat gccgacgcaa 2877841 aaaatgaatc agttaggttt taccatttga tcaggagggt atatacttct gttgataacg 2877901 cttttaaagg ggagaagaaa agtggatacg atcaaggttg gaatattagg atacggattg 2877961 tccggttctg tttttcacgg gccgctgctg gatgttctgg atgaatatca aatcagcaaa 2878021 atcatgacat cacggacaga agaagtgaaa cgggattttc cagatgctga ggttgtacat 2878081 gagcttgaag aaatcacaaa tgaccctgcc attgagcttg tcattgtcac caccccgagc 2878141 ggccttcatt acgagcatac tatggcatgc atacaggccg gaaaacatgt tgtgatggaa 2878201 aaaccaatga cagcaacggc cgaagagggg gaaacattaa aaagggctgc cgatgaaaaa 2878261 ggcgtattat taagcgtata tcataaccga cgctgggata acgatttttt aacgattaaa 2878321 aagctgatct ctgagggatc ccttgaagat atcaatacat atcaagtttc ctataaccgc 2878381 tacagacctg aagttcaagc gcggtggcgg gaaaaagaag gcactgccac tggtacgctg 2878441 tatgatctcg gctcccacat catagaccaa accctgcatt tgtttgggat gcctaaagcc 2878501 gtgactgcaa acgtgatggc ccagcgggaa aatgccgaaa cggttgacta ttttcattta 2878561 accctggatt atggcaagct tcaagccatt ctatacggag gatcaatcgt tccggcaaac 2878621 ggacctcgtt atcaaatcca tggaaaagat tctagcttta tcaaatatgg aattgacgga 2878681 caggaagacg cactcagagc gggaagaaaa ccagaggatg acagctgggg tgcggatgtt 2878741 ccggagtttt acggaaagct tacaaccatt cgtggctccg acaaaaaaac agaaacgatt 2878801 ccatcagtaa atggctccta ccttacttat taccgtaaaa tagcggaaag catacgagaa 2878861 ggtgctgcgc tgccagtcac tgctgaggaa ggtattaatg tcatccgcat cattgaagcc 2878921 gcgatggaaa gcagtaaaga gaaacgaacc attatgctgg agcactaaaa caaaagcctc 2878981 cccaaataag gggaggcttt ttcattagaa tgtttttcct gcttctttcg cacgcgcaat 2879041 cgcgtcttct ttgatttgct gtgctttatc aggctccgca ttatgtccct ctacgaaaat 2879101 gccatcgaat gatggtacgc cgaagaagtt catcatgatg ccgatgtagc ggtgccccat 2879161 ttccatctca gccgcagggc cttctgaata gtagccgccg cgcgcttgga tatgaattgc 2879221 ttttttatca gttaacaagc cgacaggacc ttgttctgtg tatttgaatg attttcctgc 2879281 aacagcaaca gaatcgagat acgctttcat cactggcggg aatgagaagt tccataaagg 2879341 agtaacaaat acgtacttat cagctgatgc aaattgatcg ctaagctctc ccaaacggcc 2879401 tactttcgct ttttcgcttt cagaaagctc ttcaaagcct gtacctgact gaagctttcc 2879461 ccatccgcta aatacatctg cgtcaatgtg cggaatgttt tctttgtaca aatcgatatg 2879521 tacaacttca tcatttggat tcgcttcttt gtaagattcg ataaatgctt tacctgttgc 2879581 catactgtac gaagttgctt cgtcatgtgg atgagcagtg atatataata cttttgccat 2879641 ttttaccagc cctttcgttt ttaaaaatca cacatcaatt attatcatac agatgcataa 2879701 tgattattct gtctctctta gactttatta tagagacaaa gaaatttact ttcaagtaaa 2879761 acatctcgaa ttaaagatta tttaactttc ccaaacagct tacttttcaa aagctgttct 2879821 caagccggaa tacagcgcgg acaattcttt actgatccga ggataatgag ggacatgcgg 2879881 cacttgaata tccgcaggca tccttttcat gataaaggat tgctcagcct gttcaaaaaa 2879941 cgcccgcagc tggttgatct cttcatcaga aaacggagca gacggacggc ggtgagcttg 2880001 cgccgagagc aaatagtacc ctaagtgctg agcaccggaa atggcaggcc agagcgcatc 2880061 cgcattcgcg tgaggaaact cgccaagcgc cttgtcatac gcatcccgaa gcctgacaag 2880121 actcaccctt aacttgtgtt cgtcggcaat ttgcccggtt aacagtttct ccataaactg 2880181 cccttccagc cggatgacat tccgcacaag ttctggcagc cgcttggttg aaaaccgccg 2880241 ccacaaaagc attgttccca acagcccgat cacgctgccg acagctacat cagtcagcct 2880301 cgctatcata aaataaccgg cgcccgcccc gccatgcata ctttctgtga taacaagcgc 2880361 atttgcggtt aaaaagggaa cagccagcgc ataattgcgg acgatcagca tctcaagaag 2880421 acattgcagc gctgcaatac aaaacgcaat ataaacaccg cccggcttaa aaaacaggat 2880481 tgcgcctgcc agtataacac cgatcaccgt tccggccgaa cgctgaatag ccctgtgaag 2880541 cgtaaaaaca acagtagtgc caagcatgac cgctgctgcc gaaagcggaa tccaatagga 2880601 gcgtgcaaag ccgaatgcga gggcaaacat atcggcggca aacagaacaa ttccgtactt 2880661 taacgctcta atcaaaactg gagacttcca gtcaaaggca tttctcaaaa agtaaaaaga 2880721 ggatggcagg cggcttggtt ccccgtcaag ctgcttatca aaacgtcctg aagcgatata 2880781 caaaacctca ttgatttctt caaacagctt ccgcctaggc tcagattcat tttcattaat 2880841 ctgaaacgta ttgaaaaccc gtgcattcgc aagcatatct ccggtttggc gaagtgcctt 2880901 ttcaatctgc gcggtctctc tgtccggcgt ttcagctgaa aaatgaataa tggcaataaa 2880961 tatgtcgtca gctttctcaa ggaggcgaaa aaatcgttca tcatgccgcg attttttccg 2881021 tctgttccct ttcccaagaa ccgtttggcg ggctgttcta agcatgagca ccgtctgatg 2881081 ctgtgcgtta tgaaaacctg gcgttccgac ggctgaaaga catgcagcca gctgatgata 2881141 tgttttttgc agcaccgctc cctccggtcc atgtttgttc cataaccagc cgattaaagc 2881201 gatacccatg gcgaaaatgc cgccgagaaa cgtcagtccc gctctgaaca gcgcttgtga 2881261 aggatcggcc ggcagcccgg aactgactaa aaaggcaagg acaaaaaaca tcggcgcagg 2881321 gccttgaatg ccgagcgcgc taaaaataaa catcgccgct gcaccgatca gccccaaaac 2881381 agccgccatc atccaaagca tcccggacaa aagcgtccct aaaccaaatg agagggcgat 2881441 cccaatagaa accaagagca gcttcaaggc gcgctttttg tacgattcac cgcccgcata 2881501 taaataaaca aagcctccga tacttgcaat taatccgtaa tccgtgtgac ctgccaatgc 2881561 accgaccagc acaggaaacc ctgaagcgaa acctgatccg atagcctttt tccaaggaaa 2881621 tggatttgca tgaatgcgaa aggcatcctt cacgataggc atgattcttt gattgttcgc 2881681 agcagttttg ttcatttgac aaaatccttt tcaatgaatg tgtagaactt ttccagtttc 2881741 ttcgctttag tatgcccaaa aacgcggtta gcttctcaat tggtgcgcac gataaaaaaa 2881801 cagagactta taccgtctct gcttcattac atcagtttat tataaaagcg gcacctgtca 2881861 ggactgtttt gtccttctgc cttccttcaa gagcaggtga ataaaaaata aaggataaat 2881921 caatagatac ccattaaaca gccaccacac aagatcaaag tcactgctga atgtccagaa 2881981 tgatagcgcc tgcagacctg aacaacaggt cagcacaaga gaaatcagcg ccatcagctt 2882041 ccagtcagca cgattcaccc gctgtaggta caagctgtac aaccctgtga cagaaatcag 2882101 gatatccagc ggaaaaaaag accagttcca agcgatcata aacggatggt catgatgttt 2882161 aaaagcccag ctttccggta tgagcgaaaa tccggctgac agccagtaca agataaaacc 2882221 gatatcagtc acgagaaaaa acagcttcat atatctcatt tgtactgccc gcttttatgt 2882281 accggctcag acaccgcaac atgctcgatc aggtttaaag acacaacacc ggcaataatc 2882341 aatccaattg aaatgacttt catgacactc acatgttctt gaaaaaacaa aaaaccaacg 2882401 actgtaatca agacaattcc catccctgac catacagcat aagcaactga tacatcaatg 2882461 gatttaagcg taagcgtcag aaagaaaaga ctccctccat aaaagaaaat caacagcaaa 2882521 ctgggaataa gctttgtaaa accagacgat agcttcatgc tgacagttcc cgcaacctca 2882581 aacaaaatcg ccaagcatag aaacacccaa ttcatgtggc atcagcctcc tcatcagctg 2882641 ttataccgtt aaacaaaaca tctacaattg attcaagtac ctctcctgtc gtgaactgat 2882701 gtttcagcgg atattcaggg tcatacactt gattgatgct ccctatatac atgtgaacaa 2882761 acaggtccgg attgatgttt ctgattctct tttgctgttt gcactcattt aataatgcta 2882821 ggacaatcgc ccattcttcc ttaataaacg cgtctaatgt aagccacgca tcgtaatggt 2882881 atttctttag ttcatttaat aatcccatgt tcagcagttc catcccctgc ggaaggctga 2882941 tcagcatttg tttcaccttt tcgagcacat ttaaactttc attttcatag atgtctcttt 2883001 ctatttgctt catttcagct ataaattgtt cgacaaccgc ctcaacaagc tgatctttag 2883061 atgaataata tgcatagagc gtccgcttgc tcgttcccag cgctgccgcc aaatcattca 2883121 tcgtaaatga aaatcctttc tgcttgatca gccggaaggt ttccgccaga attcttttat 2883181 ccatattaat cccccgcttt cggtaccaag aaaactattt cggtaccaat attatacggc 2883241 agaaatttat ggaaatcaac aatatataaa aaaacctctc ctattgggag aggtttaaaa 2883301 gacactgcgg accaaaccgc cgtccgcccg aagtgccgcg ccattgatcg cagaggaaag 2883361 cggactgctt aaaaatgtaa cgaagtgggc gatttcttcc ggacggatca gtctttgaat 2883421 aatagatgtc ggccggtttt ctttcataaa acgtgcctca gcttcttgaa cagtcaggtt 2883481 ttcaccagga tacagcgagt tcagcatggt ttccacaccc tctgttaagg tagagcccgg 2883541 catgacggtg ttgactgtga cattcgtgcc ggttgccagc tccgccaaac tgcgggaaat 2883601 ggacagctgc atcgtttttg tcgcactgta atgggccatt tcctgtgacg gcataatcgc 2883661 cgcttcactg gcaatgaaaa tcacacgccc ttcttttttc tctatcatgt tatgcaaata 2883721 cctgcgtgtc agccttacac cgctcataat attcacttca aaaaaacgaa accattcatc 2883781 gtcgggaata tcaaagtact ccgccggttc aaaaatccct aaattgttga ccaaaatatc 2883841 aacctctgga tatgcctgaa acagctcatt gcagccttct tctgttccca aatcaaatgc 2883901 agccggataa agaaccgctt cagcatgttg tgttttcagt tcatctatcg tttgattcac 2883961 tttctcttcc cggcgtccgt taatgatcac tgccgcacct tcttcagcta acgaagaggc 2884021 aatagctttt ccgatccctg atgtcgaacc ggtcaccagt gcggtttttc cttgtaaatt 2884081 cagcttcatt attcatccct ccgtttttga ttcctcttat ttattgacag aaatctgatt 2884141 ggtgaaacat ctgctctgca atcagtatga aacagctggg attgaaatgg aagtacgcac 2884201 tttttggtgc ctgtggtttg gagaaaaaat aaagcagaac ctcttaagag gttctgcttt 2884261 attgtcagta tgtatggaga cggtgggagt cgaacccacg tccagaaaca tcgattactt 2884321 aagcgtctac gagcgtagcc tgcatattta tggtttcact catcttcttg cctgcgggcg 2884381 ggccttccga gagctagtct gttcatctct tcttacgttc tcagacggga acgcaagcgt 2884441 agcctacttg gatgtgctct tcacagacac ataggcaatg tcaggaagag ctcgctgcgc 2884501 ttattaggca gctaatgcta cgttttggtt aaaactgtta gttttgccag ttatatttaa 2884561 gtgcgtgttt acgagatcgc ctctcggctc gcagctcaag ctcgatccat ccctgtcgaa 2884621 tccgtaacgt ccccttggta taagggaaat acgggagaaa atatcaagct ctcactcaaa 2884681 ctggctatag tcttattata acatgatcac ggctcttttc aattgtcaaa tccttcaaat 2884741 gaatggcgtc gtgatctgat cgtgaacaca gtatagcaca ggcctgattt tcgaatcaag 2884801 cactatgcct ttagaagcct ttttgactgt ctctgaacgc tctttcgatt tcccgcttcg 2884861 cgtccttgcg cttcagatct tcccgtttgt catagttctt cttccctttt ccaaggccga 2884921 gaagcacttt ggcaaagccg ttttttaaat acagcttcag cggaacgaga gaatagcctt 2884981 tttcctttgt taacccgatc agcttattaa tctccttgcg gtgcattaac agctttcttg 2885041 tccggagcgg atcgtggtta tagcggtttc cctgctcata tgggctgacg tgcatattgt 2885101 ggagaaacac ttctccccgt tcgattttgg cgaaggaatc cttaaggttt acgcggccgg 2885161 cgcgaatcga tttgatttcg gttccttgca gaacgatgcc tgtttcatag gtttcttcta 2885221 taaaataatc gtggttggct ttcttatttt gagataatac ttttcctgac ccttttggca 2885281 tgccagaacc tcctctctct aaggaaaaac tgtccacctt ttgcgatacg ctctatttta 2885341 ccaaatgtca cgtaccgcta caatgaaaag ctgtttccga aagaaagcaa atagagcgct 2885401 gcggccctat ttgctggttg agctgctatt tcttcttttt ccgtttctgt ttcggagcat 2885461 tctggaagcc gcgttttttc tttttcttct tcggcttagt gaaccactcc cctttttcct 2885521 cagacggagc tggagaaaca ggtgtattgg tgctttgaac acgttttctg gcaggctttc 2885581 cgcgttttct gctccggctg ctgtccaatt ctctcggacg ccgcggagtg cctttcatgc 2885641 cgacaatttc aaagtcgata ttgcgctcat ctttattgac atcgacaacc ttgactgtga 2885701 tttcatcccc gatgcggaag acgttgcctg tccgctcgcc aatcattgcg aaatgctgtt 2885761 cgtcaaagcg gtagtagtca tctgtcataa agctgacatg gacgagtcct tcaattgtat 2885821 tcggcagctc gacgaacatt ccgaagtttg tcacagagct gatcatgccg tcaaactctt 2885881 caccgatttt atcaagcatg tattccgctt ttttcagatc atccgtctca cgctcggcgt 2885941 caactgcacg gcgctccata gatgatgtat gttcggcgat atccggcagg cgttcagccc 2886001 acttttcctg tgtcgcttca tcgaccttgc cgttgatcaa atacgttcgg atcagacggt 2886061 gaacgattaa gtccgggtaa cggcggatcg gtgatgtgaa atgcgtatag aattccgttg 2886121 acagaccgaa gtgccccaag ctttgcgggt cgtatttcgc ctgtttcatc gaacggagca 2886181 taacagtaga tataaccgtt tcctctggtc tgtcacgcac agcgtccaga atgctttgca 2886241 gcgcgcgcgg atgaatattc cccgccgttc ctttcaccac atagccaaat gtcgtcacaa 2886301 attctaaaaa cttttgcagc ttttcagcat tcggctcttc gtgaatccgg tatataaacg 2886361 ggacattcat ccaatggaaa tgctccgcaa ctgtttcgtt tgctacaagc ataaattctt 2886421 caatcagctt ctcggcgaca gagcgttctc tgatcacaac gtctttaacc gctccttcgt 2886481 catcaacaag cacctttgct tctttgaaat caaagtcaac ggcgccgcgg tccatccgct 2886541 tatcgcgcag aatttgagcc agacgctcca tgtctttgaa catcggaaca agaggctcgt 2886601 atttttgttt cagctcttca tcatcatcaa caagaatttt attcacatct gaatatgtca 2886661 ttctttccgt tgttttgatg acactttgga agatctcgtg ctctgtcacc tgtccctgac 2886721 tgttaattgt catttcacaa gaaagcgtca ggcggtcaac ctttggattt aaggagcaga 2886781 tgccgtttga caatctgtgc ggaatcatcg ggatgacacg gtcaaccaga tacacacttg 2886841 tccctctttc aagcgcttct ttgtcaatcg gcgagttttc ggttacgtaa tggctgacat 2886901 cagctatgtg aacgccaagc ttgtagcttc catcatcaag cttcgtcacg gtaactgcat 2886961 catccaaatc cttcgcatcc gcaccatcaa tggtgacaat cacctggtca cggagatcac 2887021 ggcggtcttt cagatctttt tcatcaatcg tgtcaggcgt acttgatgcc tgttccatcg 2887081 cgtcagctgg aaattctccc ggcaggccgt gcttatgaat gaccgataaa atatcaatgc 2887141 ccgggtcgtt tttgtggccg agaatggttt caacctcacc ctctgcgttc atgcggcctt 2887201 caggatagct cgtcagcttg acaacaacct tatgcccttc cgcagctcca tttttcccat 2887261 ttttcggaat gaagatgtca ctcgtgattt ttttgtcgtc cggaatgaca aagccgaagt 2887321 ttctcgtttc tgtatacgtg ccgacaaccc gctgaatcgc tctttctaaa atccgtatga 2887381 cggttccttc ctgcctggag ccgcttgatt gtgagttcag acgcaccatg acgatatcgc 2887441 cgttcattgc cgtatttagc tcattaggcg gaataaacac atcacttaac gacgtatcct 2887501 caggcagcaa aaaggcgaat cctttcgcat gggctgaaat ctttcctttt attaaattca 2887561 tcttctccgg aatgccgtag cggtcgcttc tcgtccgtac gataagccct ttttcttcca 2887621 aggcgactaa cgctttgacg agctctttaa actcctcggc ttccgtaata tttaacatct 2887681 cctcaagttc ctgaacggtc agaggtttgt acgcctcttc cttcataaac gagagaagct 2887741 tttccataaa tgcttctttt tccattatcc gacctcctgt tgattaccaa tcgagcttct 2887801 ctaaaaattc atacacatcc tgatggacga ggtcacgttc tttgtcgagt gtaatgacat 2887861 gccctgattc ctcgtaccat ttcagctgtt tatcatcagt ttccacttcg ttgtaaataa 2887921 tattggcgct ttcggtatta atcatgtggt catgacgggc ctgcaccaca aatgtcggtg 2887981 aataaatcat atcgacatta ttccgcacat cagcaattaa gtcttgcagc gccttgaggg 2888041 tattcatcgg cgttttttcg aattctttca tttcctcttc aatttgctcc gggcttttcc 2888101 cctcaaactt tttgtaattg cgagcgtatg aaagaacgcc ttgatacatg acctcttcac 2888161 tcttaatatg catcggtgcg cacattggga caattccctt tatgggtaca gtgtaaccca 2888221 atttcagcga aaaaaccccg ccaagcgaca gtccgcaggc agcaatgctc tcataacctt 2888281 cagattttaa atattcatag ccatccatta cgtttttcca ccagtcttcg ggccccgtat 2888341 gtacaagttc ttcaggcggg acgccatgtc cttcatattg aggcgcgtgg cacgtatagc 2888401 cgcgttcatt caaatatcgt cccagcatcc ttacatccgc tgtatttcct gtaaagccat 2888461 gcagcaaaag caccgctttg tctccgcctt taaatgtaaa tggttttggt gtcacaactt 2888521 tcatgctcat gtctcccttt ctatctgcac gatcatttta gttttccaca gtttaatcag 2888581 aaaaaaacgt tttgaatatc atccagaaac gtgaaaaagg cctgacttca catcagacct 2888641 tatacaaaca ttgccctata ggatataagc aagcgcaatc gttaacacga aaaacaagac 2888701 tgccagcact accgtaatgc ggtgcaaaat taaatcaaga cctcttgctt tttgtttccc 2888761 gaagagctgc tccgctccgc ctgaaatcgc accagataat ccggcacttt tactggattg 2888821 aagcaaaacg acaataataa gtgcaatgct gacgataacc aataaggtaa tcaaaactgc 2888881 gtgcatccca tacacctcca gactcactgg ctacattact tctattttac atgaaaaggg 2888941 ttggcatgtc acgctgtatc agacgccaaa aggccggata agacgtttta tcttggttac 2889001 cctattcata tgaaaaggtc aaaggagaaa agcgatgccg cttatcagca tagacagcag 2889061 gaaacatctt ttttatgaag aatatggaca gggaatccct atcattttta tccacccgcc 2889121 gggcatggga cgaaaggttt tttattatca gcgccttcta tccaagcatt tcagggtgat 2889181 ttttccggat ttaagtggcc acggtgatag tgatcacatc gatcagccag cgtctatttc 2889241 ctattacgca aacgagatcg cgcaattcat ggacgctttg cacattgata aagctgtgtt 2889301 attcgggtat tctgccggag gcttaatcgc gcagcatatc ggcttcaccc gcccggacaa 2889361 agtgtcacac cttattctgt ccggcgccta ccccgctgtt cataacgtaa tcggccagaa 2889421 gctgcacaaa ctgggaatgt atctgcttga aaaaaacccc ggtttgctca tgaaaatcct 2889481 cgctggcagc cacacaaaag acagacagct tcgcagcata ttaacagacc atatgaaaaa 2889541 agcagaccag gcccattggc atcagtatta tctggattcg cttggctaca actgcattga 2889601 acagctgccc cgcctagaaa tgccaatgct gtttatgtat ggcggcctgc gggactggac 2889661 ctttacaaac gcaggctatt accgaagatc gtgcagacat gccgaatttt tcagattgga 2889721 atatcaggga catcaattgc cgacaaaaca atggaaaacg tgcaatgagc tggtgacagg 2889781 gtttgtgctg acacatcatt cataggaata gaaaacgctt ggcttccttg cgttttttgt 2889841 tactttattg acttttgtca acgaaatcat agtaaaaaag atcctcaaat ttcaaattaa 2889901 aatagtgaag cattttacca atcacaagct gccccggcct tctttctcca ttcagcacgc 2889961 ggctcagtgt ggcgggtgag actccgattt ccagcgcaag ctgattaagg gaataatcgt 2890021 tattaaccat atactgcaag acataatcac gtctaatctg tatcttttct actggcactt 2890081 tcctcacctt ccattcctga aaaacttttt tctatacttt tacattacgg cttatgttaa 2890141 cttttgtcaa tacatttcca gtctacctat tccctttagt caataaacat actaaaatat 2890201 gagtaacagt gagggacggg gtgagatata tggaaagctt tggcgaacaa ttacgggcat 2890261 tgcgtgaaga gagaaagtta acagtcaacc agctggcgac ttattcaggc gtaagcgcgg 2890321 ccggcatctc cagaatcgaa aacggaaaac ggggcgttcc caaacctgcc accatcaaaa 2890381 aactggcaga ggccttaaaa attccttatg aggggcttat gtacaaggct ggttacatcg 2890441 aagaagtgca tgaagccagg gccccttatg aaacgaagtg caagctgctt gaaaaagcgg 2890501 aggcctatga cctgaaaaac cttgcgcttc ttgagaacga aaagtggcaa tatctcaata 2890561 aagaagattt gctcatgctg gatcattatt tttcgtttat ttcagatgaa gcgaaaaaac 2890621 ggtctgctga tgactgactc ttgatagaaa tgtgaggcga tagaccatgt caccgttcgg 2890681 acagcaatta cgggagctgc gccgcgcccg caaactgaca gtgaatcagc ttgcggtgta 2890741 ctcaggcatc agctcggcca ccatttcaaa aattgaaaac ggcaaacgcg ggacgccaaa 2890801 acccgccacg attaaaaaac tggcagccgt cctgaaagtg ccgtacgaaa acctaatggc 2890861 cgccgcaggc catattcagg cctttcctga agaaatccgc gaagcatctg aaggctatca 2890921 atccgtttat gaaatttacc agacggctgt cacacgcgga gcggagcacc tcccgatttt 2890981 caatagtcaa aaatgggaac atctctcaaa gcaggatatt gaaaatctca gcaaatactt 2891041 cgattttttg tcttcagaag caaaaaaacg cgcctcttcc tcataatccc ctgtttctct 2891101 ttctatattt tatcaatcac gcttgcatgc cctccctcgt tatttgcgtt ataatagtga 2891161 cagacgaggt gaaaagtatg aaccaatcag aaatgtgtcc tagatttgaa aaagcagtcg 2891221 acatcttaag taaacgctgg gtcgctttaa tcgtatttca gctcttgaac gggtcgcagc 2891281 gatttagcga aattgaagca gcacttccaa atctaagcgg cagagttctg tcagaacggc 2891341 tgaaagaact tgagcttgaa ggagtagtga agcgggatgt catccctgaa actccggttc 2891401 gcatcgaata ttcattgact gataaaggaa aggcactagc acccatatta ggtgagattt 2891461 ctaaatgggc gactgaatgg attgaccctt cctttcttga ctaattgcta aaatggttct 2891521 gatctcaaag acgagaaaag aaccgttttt tattttccag gtgaaaaaaa gatatctcag 2891581 ccgatatata gtacatccac acattacgtt tttaaaggag accactatat gcgactgacg 2891641 atttcccgca aattcagcct ggtatttttg acactgatcc tgatcaattt acttgtaggc 2891701 ggaataggcg ttcttaatat gcagcatatc attcaaaaaa cagatgaaat caacacaaaa 2891761 tggattgacg gcatcaaagg aatcacttca attaattatg taaccgagca cctgtcttct 2891821 aaagaaaagg actttctgat ttatacagac aaaagtaaaa tggatacact tgatcaagaa 2891881 atgaatcaaa tcatggaaga cattaaccaa aagctcgata actacgaaaa aacgatctcc 2891941 actgataaag agcagaaact gttcgagcag cttcaaacta aagtgaatac ctatatggat 2892001 attcatgcgc aaattatcga aagcggccgc acgaatgaca tggacaaagc aagaggttta 2892061 ttggttcaga ctgaggccag ctttgaggat atgaaaaaaa caatcactca gcttgttgac 2892121 ttaaatcaag aaggcagcaa cacagcggta aaagaaacga aggccgtcta tcataaaggg 2892181 ctcatttaca ctgctttgct tgtggcagca tcaatcctca tcagcatttt catctggctt 2892241 tatatcacgc gaaacattgt aaagcctatc attcgcatga aggaatctgc caatcatatt 2892301 gccgaaggcg atttgtcgaa cgatatggag gccctcaact caaaagacga gctgggtgat 2892361 ctgaatgaag cgctgcaaaa aatggtaggg aatctgagag atattgtcgg atattctaaa 2892421 gacatatcaa gccgggttct ttcttcttca caggtgcttg caaccgcaac gaatgaaaca 2892481 agatccggca gcaaacatat taccgagacg atgaacgaaa tggctgaggg ctctgaacag 2892541 caggcccaag acgcggtgac gattgccgaa tcgatgaatg agtttaccga aagcattgat 2892601 aaagcctata atcacggcat cacaatcagc gatacgtctc aaaacgttct cgaactcgcg 2892661 gtaagcggga acgaaaatat ggctacgtca ttacagcaaa tgaaaaccat ccatcatatt 2892721 gttgaagaag ccgtgcataa agtgagatca ctggaacagc attctcagga tattaacaag 2892781 ctcgttcagg tcatcaacgg gattgccgag cagacgaatt tgctgtccct taacgccgcg 2892841 attgaagctg cccgcgctgg agaaagcggc aaaggcttcg ccgttgtggc agaggaggtc 2892901 agaaagctgg ctgacggcgt ttctgattcc gtgcaggaca ttacccggat tgtaaacggg 2892961 acacagcagg agatccacac tgtcattacg tacttggaaa gcagctttac agaagtcgaa 2893021 aaaggaacgg aaaacctgac agacaccgga caggctatgc agcatatcaa acaatccgtc 2893081 acccatgttg cagacagcat taaggaagta acggatggct tgaagcagtt aacaaaccaa 2893141 tcgattacca tcaatcaatc gattgaaaat atcgcttctg tatccgaaga gtctgccgcc 2893201 ggcattgaag aaacattttc aattaccgag caatccgccc attcgatgga tcaagtgctt 2893261 ctaaatgctg aagagcttga gcagctggcc aatgagctta atgagaagat gggtcagttt 2893321 acgatttaaa gagaaaaaag aggctggact ccagcctctt tttctattct atgcagctga 2893381 ttgaacatgt ttcgccccgg ttcttttttt cttcaccgga cttaatgccc gctccagcca 2893441 agccatgagc aaatccgccc ctaccgccat caccgcagtt ggtatcgctc cggctagaat 2893501 aatcgcagtt ccgtttgttg cgtttgagcc gcgtacgatc atgtccccaa ggcctccggc 2893561 accgacaaat gtgccgatcg ctgtaattcc gatggcaatg acgagagccg tgcgaaggcc 2893621 cgccataatg acagaaagtg cgagcgggag ctcaaccatt ctgagcactt ggaatttcgt 2893681 catgcccatt gcttttccag attctaagta ggcatgttca atactgataa tgcctgtgta 2893741 cgtgtttcga ataatcggca gcagggaata cagaaataat gatagaatca cggtatttgc 2893801 gccgagcccc ataacaagca ttaagacggc cagcatagcg agcgccggga ttgtttgaat 2893861 aacgtttgtt acggcaaaca cccaggctga caaacggcga aaatgcgcga tgaggattcc 2893921 ggccggaacc ccgacgacag cggcaaataa aacgccgtaa gccgacatga gaaagtggcg 2893981 gccgaattca tccatgacgt aactgccatt ctgcgcgtaa tacgtcatta actgttcaag 2894041 cacgttcatt gacctcttcc ccctttcacg attcgaaata gcgatgtttt tctaaatatt 2894101 ccttggcaac gacagacggt tctttgagat tgccgtcgac ttcatagtta agctcctgca 2894161 tcgtggctgt gtcgattttt ccgagcattt tcttgatgat gccttcaagt tcaggatgtt 2894221 ctttgagcac cttttccgga acaaccggag agcagtcgta cggcgggaaa aattgtttat 2894281 catcctttag cattttgaga ccataggact tgattcttcc atcggttgaa tacgcaagca 2894341 caatgtccat ttttccgctt ttcaccgcgt cgtacacaag gccgatctgc atcggatacg 2894401 tgccgccgaa tgtcatgccg taggttttcg taaaatcctg atagccgttt cctttgagct 2894461 tcatccaata gttatcaacg cccagcttta attgcggcgc ccatttttta acgtctgata 2894521 cggtctctaa atggtattgg tcggccagct ccttgctgac tgtaaaggca tatgtattat 2894581 caaacccgta ggagtcatac cactttaaat catatctttt tttaaactcc cgctgagtaa 2894641 gcgccagcgc tttgtccgga tctttttcag gttccattct caacgtgcct gtcagcgcgt 2894701 ctcccgtata tcttgtggcc gcaatgtcga tttccccgtt cattaaagcc tgctgctgca 2894761 ccgcgttgga gccaagattt ttaatcgttg ttgttttgag atcagtatgg tgttcgatca 2894821 actggccaag catgctggcg atgatttctg attcgctcat gctttgcgcg ccgattttaa 2894881 tggtctggtc tgcagcagcg ctgagaccag gaagcgaaca gccgctcagc gtcagcgttg 2894941 ccgcaagtgc taaacctatc attaatttga gatattttct tttcatgagc cgcctcctta 2895001 tgacaattcc ttcaatctct gcatgccggc aggtgtcagt tttcgttcag caactgccag 2895061 cacataatca atcacaattg ccaatatcgt gacaggtacc gcgcccccga tgatatattc 2895121 cggctgatat aaattcagtc cgataaaaat gtaatcaccc aatccgccgc ctccgataaa 2895181 ggaagcaagc gtggcccagc cgattaagta aatcgtcgat gttctgattc ccgccatgat 2895241 cactggtgcg gcaagcggca gctccaccaa gcggacttgt tcagccggcg tcattcctat 2895301 tcctttacca gactcgagca gatttttgtt gacgccgcga atgccggtat acgtgttgcg 2895361 aagaatcggc aatacggaat agaaaaacaa agccacaatg gccggaacct tccctacacc 2895421 aaggagcggg ataaaaaaag cgaggatggc cagactcggc agcgtctgaa tgatattgac 2895481 aatgccgata atggtgccgg ctcctttttt cattctggta agcacaaccc cgagggggac 2895541 ggcaaccagc acacctaaga tcacagcaat gagcgatatc gtaatatgct cgtatgtttt 2895601 ataaagaagc tctcccccat tggtttgcaa aaattgaaca atatgatgca tgacttatcg 2895661 cccctcccta tgacaatgct gcgagctgct tttcttctcc ccagagggag tcatacacga 2895721 tgtcgaccag acttgccctc gtcacaattc cgatcaggcg tcggtcttca tccacaacgg 2895781 gaacatattt gacaccccgt tttaaaattt tgcggaccgt gtcgcgcagc agtgtgccgc 2895841 ccagtactgt gtatatatct tcatgtaaaa cttcactgac gagattggcc tttttccggc 2895901 attgatcaat gatttcaaca tcgacatagc cttgcagaac gcgctcgtca ttgacgacca 2895961 gcaatgaatc gacccgttcc tgcctcatca gctgaatggc ctcagaaagc gttttatccg 2896021 cggtgatcgt tacaggctgt gtgttcataa tctggtcaac ccgttcaaca tccgggctgg 2896081 atgactgaat cagccgctcc ttgccgataa attcctcaac aaattcgtct gccggatttc 2896141 ttaaaatgtc atcgggcgtt ccaacttgaa cgatttctcc cgcttttaaa atcacaatcc 2896201 ggtctgccag cttaatcgct tcatccatat cgtgggtaac aaatacgatg gttttatgta 2896261 aggttttttg cagtttttta aattcttcct ggagggaatc cctcgtaatc gggtcgagtg 2896321 ccccaaacgg ttcatccatt aagataagcg gcggctccgc ggcaagtgcc cgtaatacac 2896381 caattcgctg ctgctgcccc ccgcttaatt catgagggta acggtctaca tattctggcc 2896441 ccatatcgac caattttaaa agctcacgcg cccgctcttt ccgctgctgc tccggccatt 2896501 tcagcagttt tgggacgagt gagatattct gctgaatggt catatgggga aacaggccga 2896561 tctgctgaat cacatagcca attttgcgcc tgagctctac aggatcctgg tccatgatgt 2896621 tttcgccgtc aatgaaaatc ttcccggcgg aaggctcaat taatcggtta atcattttca 2896681 ttgttgtcgt ttttccgcag ccgctcggcc cgataaagca gataaattcg ccttttgcaa 2896741 tcttaagatt tacgttgttc acggcttttt tgccgccctt gtatgttttc gagacatttt 2896801 ctaatgtcag caaacatcgc acctccaaaa ttaagtttat tcaatttgtt cagtttaaat 2896861 ttaatttttc agacaattga atgcttccca ttatagaata aagtttataa aataaaaagt 2896921 ttacaatttg ttcatattat ttataaagta tgtgtaaacg ctgatttacc cgcattgacg 2896981 tgtgttgatc tccttattgc tccaatttcc tgccaaattc tcttttgaca gcattttcgc 2897041 cgtatcaaaa atgtggtata ttgacatcgg aattgttagc tgaaaggatg aaaccgttgg 2897101 agaaagatcc gttaacgatc attgaacaag ccgaggacca ttttatagaa agaatcgcgg 2897161 aaaacatgca tgcatttgga atgccctcta ccgtcggacg agtgctgggc attatttata 2897221 tgaatcgaaa accgatgacg cttacggaat tatctgaggc caccggcatg agtaaaacac 2897281 gtatgagcca ggtagtgcgg gaaatgcttg atgccaacat tgccgagaag gtattcgaaa 2897341 aaggcgtgcg aaaagattta tatgaggttg agcaggacta ctatcaaaca tttatcacgc 2897401 tgttttcagc cacctggagc aaagtcgtca gcaaaaacaa aatgatgcat aaaaaactca 2897461 atcgggagct gcttagcgtg ttggatgaag agcttactcc tgaagcggaa gaaaaagtga 2897521 atgagctgct gaaggaatta aaggaatggc tcgattatta taattggctc agccgtttga 2897581 ttgagttttt tgagagcgaa gacattttta aatatgtgcc gaagccgtaa aaagttccca 2897641 aattcaattc tgggaacttt tttaagtcca atccaaatgg ttgaatatca aacttcgagc 2897701 tcccaacgct ggaaaatatg tttaacagat actaacacat gttgtttatt taaaaaaacc 2897761 acctctgttg tatttaaata gaggtggttt ttctatcagc tataataaaa tttccttttt 2897821 tctttttaat cgggcttaat gctcgttcaa gccagcccat gaccaaatcg gcaatcaccg 2897881 ccatcagagc tgtggggatc gctcccgcta atataatcgc ggttccgttt gtggcgtttg 2897941 atcctctgac gatgatgtcc ccgagaccgc cagcaccgac aaatgtcccg atggccgtaa 2898001 tgccgatcgc aatgacaagc gcggtgcgca ggccggccat tatgacagaa agcgcaagcg 2898061 gaagctcgac catccgcagc acttgaaatt ttgtcatccc cattgctttt cccgattcaa 2898121 gataggcgtg ctcaatactg ataatccctg tatacgtatt tctgataatc ggcagaagag 2898181 aatacagaaa taatgacaat atcaccgtat tagcgcccag ccccatgaca agcatcagca 2898241 cggcgagcat ggcgagagcc gggatggtct gaatgacatt cgtgaccgca aaaacccatc 2898301 cgcttaatct tctgtatctg gctatcagga tgccgagcgg aattccaaca atggcggcaa 2898361 ataaaacgcc atacaccgac atcagaaaat ggcggtaaaa ttcctgcagc acgtaaccgc 2898421 cgttttgcga atagtatgtg ccaagctgct gtagtacttc catatgatcc acctcttttc 2898481 ttagtcaaaa taatgatgtt tctctaaaaa ttcctttgct acgacagacg gctccttcag 2898541 cttgccatcc acctcataat taagttcctg catcgtttcc gtgtcgattt gcccaatcag 2898601 cttattgatc acaccttcaa gttccggatg ctccttaagc accttttccg gaatcaccgg 2898661 tgaacagtca tacggcggaa agaaacgctt atcgtctttt aagattttca gatcatatgc 2898721 tttaatccgt ccatccgttg aataagccaa aaccgcatcc attttcccgt ttttgactgc 2898781 gtcatagact agcccgatct gcattggata agttgtgccg aactcaaagc catatgtgct 2898841 gacaaagcct ttatacccgt cgccttttcg tttcagccaa gcattgtcga cgcctaattt 2898901 atattgggaa gcatttttct tcaggtcaga cacggtgtta atatgctcct tttccgcaaa 2898961 cttttttgtt acggtgaagg catatgtgtt atcaaagccg taggaatcaa accatttata 2899021 agaaaagcgc ttttgaaact cgttctgcac aatgttcagc gcttttttcg gatctttctc 2899081 cgcttccttg ccgagggtgc ttgttaaatc tgttccggaa tagcgcgtgg ctgaaatatc 2899141 aatgtcaccg cccagcatcg cttggtgctg aacatagttt gagccgaggt ttttcactaa 2899201 agcagtattc aaatctgtat catgttcaat aagctgcgcg atcatattcg ctacaatttc 2899261 tgattctgtc atgctctgcg ccccgatttt gatcgtatcg tcagaagcgc cgcctagacc 2899321 cggcagagag cagccgccta gcagcatgac aaagacgaga gcaaacgcgc caagccattt 2899381 gatttttgtc attttcaaca gtgccaactc cttacgatac ttccttcatc ccttgcaagc 2899441 ctttcggcgt cacctttcgt tctgtcacag ccagaacata atcaataata attgccagaa 2899501 ttgtgacagg cacggcaccg ccaatgatat attcaggctg gtataggttc agtccgataa 2899561 aaatatagtc cccgaggccg cctcccccga taaacgacgc aagtgtcgcc cagccaatta 2899621 ggtagatcgt tgatgtgcgg atccccgcca tgatgatggg aatcgccagc gggatttcaa 2899681 cgagccgaat ctgctcccag ccggtcatgc caattccttt ccccgattcc aggaggtttt 2899741 tatttacacc tttaatgccg gtatacgtat tgcgcaggat cggcagtacc gaatagaaaa 2899801 ataaagcgac aatcgcaggc acttttccta cgccgagaag cggaataaaa aaggctaaaa 2899861 tcgccagact cggcagggtt tgcacaatgt ttacgaaacc gataaccgca cctgcgcctt 2899921 ttttcattct ggtaagagca acgccgagcg gcactgcaac gataatgccc aatacaacgg 2899981 ctatgagtga aatatataaa tgctctcctg ttttatacag cagctctccg ccgttcgttt 2900041 gcaaaaaagt catcatttga ttcatcttaa aagagctcct cccctggtca gatcgtcatg 2900101 agctggtttt cctcgtcgcc ccaaatggaa tcgtatacga tatcaacgag gctcgctctt 2900161 gtcacaatcc ctgctaaatg gttctgttca tcgaccaccg gaacatactt gatcccctgc 2900221 ttcaaaattt ttcggactgt atcgcgaaga agcgcccctt tttgaacggt atatatatct 2900281 gaacggtata catcgccaac gatgctcgct tttttgcggt tttgatcaat catttccaca 2900341 tcaacatagc ccttcagcac gttttgccgg tccacaacga gcagcgagtc aacacgtttt 2900401 tctctcatca gctgaatcgc ctgagaaagc gttttgtccg cagataccgt caccggcgtt 2900461 ctgttcatca tttgctctac ccgctcgata tccggtcttg actgaatcag gcgctctttc 2900521 ccgataaatt cttcaacaaa ctcatttgcc gggtttcgaa gaatctcatc aggtgtgccg 2900581 acttgaacga tttctcccgc ttttaatatc acaatcctgt cagcaagctt aatcgcttca 2900641 tccatatcgt gggttacaaa cacaatcgtt ttgtttaagg ttctctgcag ttttttgaat 2900701 tcttcctgaa gggaatcacg cgtaatcgga tcaagcgctc cgaacggttc atccattaaa 2900761 atgagagggg gttccgctgc cagggcgcgc agcacgccga ttctctgctg ctgtccgccg 2900821 ctgagctcat gcggataacg gtctaaatac tctgggccca tatccacaag ctttaacagc 2900881 tcgcgcgccc gttctttccg tttttcctca ggccatttca gcagctttgg tacgagtgag 2900941 atgttctgct ggatggtcat atgggggaac aaaccaatct gctgtatcac atagccgatt 2901001 tttctcctca gctcaaccgg gtcctgttcc ataatatttt ctccgtcgat aaagatcctt 2901061 ccagacgatg gttctatcag tctgttgatc atcttcatcg tcgtcgtttt tccgcagccg 2901121 ctcgggccga taaaacagat aaattcacct tttgcaatat ctaaatcaat gctgttcaca 2901181 gcttttttgc cgcctttata tacttttgac acttgttcca atttcagcaa tccgtgcacc 2901241 tccgcaggtt tcctttaaat tttctgaaaa gtataatcct tattatagtt tgaactttgt 2901301 aaaataaaaa gtttacaatg tgttgaaatt atatgttatt tatagattat ttattgttat 2901361 gaccgagacg gaaagggtgt tcttacaatt actccggata cctcccactt cctctgcatt 2901421 cagctatttt caacaccagg aagaaatatg atatattgac accatcaatt gccatttgaa 2901481 gggatgatca gctgtgaaaa aaaccgctct cgacatcatt gaacatgctg aagagcatct 2901541 cattgagaag attgccgaaa atatgcatac gtttggaatg ccttcaactg tcggacgtgt 2901601 gctcggaatt atttatatga atcgaaaacc aatgacctta agcgagctct ctgaggcaac 2901661 gggcatgagc aaaacacgga tgagccaggt tgtccgggaa atgatcgatg ccaatatcgc 2901721 cgaaaaggtg tttgaaaaag gcgtacgaaa agacctttat gacgtcgagc aggattatta 2901781 tcaaaccttc atttctttat ttgcggcgaa ttggacaaag gtcgtgagca aaaacaaagt 2901841 gctgtataaa aaattaaacc gggagctgag tgatctttta caaagggacg ggcttacccc 2901901 ggaagcggaa gagaaagtca atcagctgct gaatgaatta aaagaatggc ttcattacta 2901961 tgattggctg agcaggttga ttgaattttt tgagagtgag gaagtctttc ggtatgtgcc 2902021 gaaaacaaaa gaatgcagct ctctaaaata agagagctgc tttttgcatc atgaagttaa 2902081 gaccggaaac atgcctttca gcccggcacc aatcatcccg accgcaacca cggctaagat 2902141 taatcccatc agtctggtaa tcacattcat ctcggttttt ccgagtttgc tgctgataaa 2902201 agcagaatag tggaaaaaga gaaaggtcag ggcaataacg gcggctatgc cgatcatgac 2902261 agccgcataa tgaccaatgc cgctatgtcc ggcggaaagg ctcatcactg ttgcaatcgt 2902321 tccgggccca gcaatgatcg gaatggataa aggtgtgact gatatatccg ctttttcctt 2902381 gctttcctta tgttcatcat ggtgaagaga ttgcacgtgc gattctttcg cattcaatag 2902441 attataggca atgccgaaaa tgaatatgcc gcccgccact cggagcgcgt gaatgttgat 2902501 atcaaacagt ttaaagataa gatgaccgaa aaccaaaaaa gctgcgagaa taaaaaagga 2902561 taaaatagct gccttccggg caatcgcttt tctttccgct gcagtatagc cttctgtcag 2902621 cgtcagaaat atcggtacgt ttccgatcgg attcgatact gcgaataaag aaatgaagac 2902681 gtgaacgata aatgagaaca tcatatacct ccttgttgat agtctctgca caggaaatag 2902741 aatgattctc caccctttta cccggaggcg atttcccggt aaacctttat agcctgtcag 2902801 aaacgcgcca tgctacaatg aagtgacaaa ttgaatagga aggacgtata cagatgttca 2902861 aaaaaattgc ggcagatgcc ttgggcttat ctgatatcgg aaaaattatc gaacctcagg 2902921 actatgacaa aacagacgca gatgactatg tcatgcatga agataatgag aaaatttatt 2902981 tcttgattaa aacaaaagca gacgagtatt gctttacgaa cctggccctg atccatgtgg 2903041 acggcgaacg cgccacttcc tcaaaacgaa cgttgaaacg ctatccttat tcgcaatata 2903101 aaatctctga cgtttttctt gaaactgccg gaaaagtgga tttggatgtt gaaattaagt 2903161 tcaagctggg cggtgaacaa ttcgacattg atgtccacaa agaccagatt gaaaagttaa 2903221 aagaccttta taaagcactg cttcgcatcg ctgaaacaac ctatgaaaat gacattttaa 2903281 tcaatcaagc ggagcaaagc ttagataaag cagtgacgat tcttcaccat acccgccctg 2903341 agcacgtcaa tattgaaacg caatacaaag agctgaccga attcggattc acttggctga 2903401 catccgttcg ctcgcagtat catattaagg attttgggga tgtatttgag aaatatatta 2903461 ataactagat aaaaaaagac acagctgcta tcgtgctcgt gtcttttttt gtatgaatat 2903521 tgattacttt acaacttttt tcttttataa taaaactatt agtctatttt ccctatatta 2903581 cagataaagg agttatttta tgtattgtcc tcaatgcggc catcaaacag atggcggaaa 2903641 tttttgtgag aaatgcggat caccgctccc cggtcaatca ggccaccagc atgcagctca 2903701 aactggagcc gctgcaaagc aagcagcaaa acagttcggt tcatttgtct tatccgtcct 2903761 gaaacgccct tatcaggaat gtaaagcaac aggcggagaa cagctgatca gcgcaatcat 2903821 tacgatggtt cttttcagtt tgctgacccc tttgatgttt tatattcttt tttcagacgg 2903881 tcccggaagc gtaagcttta cagcaatctt cttagagcca accatttatt ttattttatt 2903941 tctatttggc ctgcatgcat gcatcttttt cgccctgaaa atcgcgggaa accaagtgtc 2904001 tttcaaggat tcattctcaa gattcggagc atttcttatt ccttttacgg ctattttgat 2904061 tcttgccctt ttcttctttt tattacatac agacatttgc tttaccatat tagccgttgg 2904121 tttaatcggt gcattcttcg ccattcctcc tgcgatgctg agcagttacc agcattcata 2904181 taaagggaag gttgatttca tttactcaac gattgtgatt tatctgatca tctgcgttac 2904241 atttcagctt attatcgaac actatgtcaa agaaattttc cgttatatgc tcttttaaaa 2904301 acaaccccat cacctgctgg tgatggggtt gttttattga atagacgtta agtaaattct 2904361 tccgttcttc actacgccgg tgtaggtcca gttatatgtt ctgagctttg gactgccgcc 2904421 tgattttgtg atatagaatt cttcatacgt cttaatcgtg atagccgacc cattttggct 2904481 ccagcttttc acttcatagt tattaaagtc ttctgttgtc ccctctttat ttaatttcga 2904541 cacgagatgc tgctggtcgg aataaaggga actgcctttt tcaaggctgt cttccatcag 2904601 tgagaaatta ttttgattca cggcatctgc ctgactttgc agataactgc ccataaataa 2904661 tgtcacttgt tcatctgtaa catcgccgct tgcagagctt tcactgcctt tgtttttcga 2904721 gccagcccag gcggaagtgt atgtctctgg tttatcattt ttgattttct ttatatttgt 2904781 gcctgcagat tcgaatgttg attctgcatc ttcgaaaatc cactttttct gttttttatc 2904841 atatgaaaga agatattcat aactcggact gtcgtcagtc atttcagact ttgtatagtc 2904901 gttatacgaa gaagactggt gaagttcttt tcctgttacc gatacctgcc acgttccgtc 2904961 gtttttctga gagagggcaa atgtgtccag gtcaaaatca gtttccaagt atctatcttt 2905021 taagtatgaa tccgcgcttt tcatagaatc gacggtgtcc ttcgtctccg ccttccaatt 2905081 ggcacttgcc tctgtcatct gggctgtatt cccatcagat agagctttgg agtattgttt 2905141 tgttgttttg acaattgtgt tcataatctg ttcctgtgta tcttgatcag gaattaacgt 2905201 taactccatt tctttatcat cgatcggaac gccggcagtt tttgtttttc cccacggaaa 2905261 ttctgcctcg actgaagctg tcattgatcc atctgtcagc agcggaccat atgttacgga 2905321 tttgaacgga tctttatgaa ttgatttacc gttaatcagc aaatctccct tcccgctctt 2905381 gatgtcattc gctaagctga atgtcacatc gtctgcttcc aatgagagat caacacgaaa 2905441 gctgctatcg ccaatcgcct gaatgtcttc ctttttcaca aggtcaacga catcgttttt 2905501 cagtttggct gagactgtat attcgccggg aatgtacgga ccaagggttt gtgcttgatc 2905561 tgctttcttt acagatccgg cttcctcttt attgacatat agatcggtat ttttataatt 2905621 gctgctcact tcaaaataaa caggtgctac ctttaagtca taatggtcaa ataccagcag 2905681 gcttttcccg tctttttccg catatacgat atccttctgg gctgtttcat cacgcagcga 2905741 tgcaaaaagt tcatcttttt tgtctggatg atccttcaaa tatgtaagaa acggttttac 2905801 attattttta gtgagtttaa gattgtcatt taccggtgta agcagagtcg cgatttggtc 2905861 ctgatcccca tcatttacgg cctgttcaaa cttgtctact aacctatcct ttgaagtaaa 2905921 atacgctccg gttttatatg cggcgaataa tataacgcac gccgcggcaa tgctgctcca 2905981 taaaatgatg gttttcttag ggatcggttt tcgcggagcc tgcctcgttt ctgcagtgct 2906041 agctgtttct tgatttgcct gtttgctgcc ccctccgatc ggggtgccgc attgtttaca 2906101 aaacttggct ccttcattat tctgggagcc gcaattctta caaaataaca tgactttcct 2906161 cctattctac taatttgata acatttactg cttttcatat tttataataa aacagaatga 2906221 aattgggaac gaatgaaaaa attaaatgtc tatcagacta aaaaggtgga atgaatatgc 2906281 aaaagctcag gattgaatta ggagaagaaa caaatgacga attatatgat ctattgctgc 2906341 tcgccgatcc atcgaaagac attgtagatg aatatcttga gaggggagaa tgttacacag 2906401 cttgggccgg tgatgagctt gcaggggttt atgtattgct aaaaacaagg ccgcaaacag 2906461 ttgaaattgt aaatattgcg gtaaaagaat ctcttcagaa gaaaggcttt ggcaaacagc 2906521 ttgtacttga cgccatcgaa aaagcgaaga agctgggggc ggacacgatt gaaatcggaa 2906581 cggggaattc gagcattcat cagctttccc tctatcaaaa atgcggattc cgcattcagg 2906641 cgatcgacca cgatttcttt ctcagacatt atgatgagga catttttgaa aacgggattc 2906701 aatgccgcga tatggtaagg ctttatttgg atctctgaaa gcataaaaaa gccgccgaga 2906761 gaaaatcccg gcggtctttt tattacttgt ttaagttgta gaaagagttg ataccgtggt 2906821 attgagcagt ttcagccaac tgatcttcga tgcgaagaag ctggttgtat ttcgcaacac 2906881 ggtccgtacg agacggagca cctgttttga tttgtcctgc gtttgttgcc acagcgatgt 2906941 cagcgattgt gctgtcttca gtttcaccag aacggtgaga gataacagct gtgtagcctg 2907001 cgcgtttcgc catttcgatc gcatcgaatg tttcagtcaa tgtaccgatt tggtttactt 2907061 tgatcaggat agagttgcct acgccgtttt taataccttc agaaagtttt ttcgtgtttg 2907121 taacgaagag gtcgtcacca acaagctgaa cttttttgcc aagacgctca gtaagaagct 2907181 tgtggccttc ccagtcgttt tcgtcaagtc cgtcttcgat cgagatgatt gggtatttag 2907241 aaacaagctc ttcataccag tcaaccattt cagcagatgt tttcacaacg ccttcgccag 2907301 acagatggta tttgccgtct tctttgttgt agaactcaga agatgcagca tccatagcaa 2907361 gtttaacttc ttcgccaggt ttgaagccgg ctttttcgat tgcttcaacg attgtttgaa 2907421 gcgcttcttc gttagaacca aggtttggag cgaatccgcc ttcgtcacct acagcagtgt 2907481 ttaagccttt tgcgcttaat actgatttca ggctgtggaa gatttgagcg cccatgcgaa 2907541 gtgcttcacg gaagttagga gcacctacag gcatgatcat gaattcttga atatccacgt 2907601 tgttatcagc atgctctccg ccgtttacga tgttcatcat cggtacagga agcgtttttg 2907661 agttgaatcc tccaaggtat tggtaaagag gaatctgtaa gaaatcagca gcagcacgcg 2907721 cacaagccat agatacgcca aggattgcgt tcgcaccaag tttgcctttg ttttcagtac 2907781 cgtcaagctc gattaaaagc tgatcgattg cgttttgttc agttacatca aagccaagaa 2907841 gctctggagc aatgatttcg tttacgttgt taacagctgt taacacgcct tttccaaggt 2907901 aacggtcttt gtcgccgtca cgaagctcaa ccgcttcgta ttcacctgta gaagctccgc 2907961 ttggcactaa tgcgcggccg aaagctcctg tttctgtata tacttcaact tcaactgttg 2908021 ggttgccgcg ggagtctaat acttcgcgtg cataaacatc aacaatgtat ggcatgagtt 2908081 ttgtctctcc ttttgatttt caaattattt ttgaattaaa gatgttcctg tcatttcttt 2908141 cggtttttca acaccaagaa ggtctaataa cgttggtgca aggtcgccta ggattccgcc 2908201 ttcacgcagc gtaatgcctt ctttcgttac aatcacaggg actgggtttg ttgtatgcgc 2908261 agtgtgcggt tcgcctgatt ctgtaatcag aatgtcagca ttaccgtgat cagcggtaat 2908321 gatagcgtgt ccgcctttag caaggatcgc gtcaacgact tcgcccaagc attcgtccac 2908381 tgcttcaatt gctttaattg ttggttcaac cattccggag tggccgacca tatcagggtt 2908441 tgcgaagtta agaatgatcg cgtcatgctt gtcagcttca atttctttga caagcgcgtc 2908501 tttcacttca tacgcactca tctcaggctt caagtcatac gttgcaactt taggcgagtt 2908561 gatgagaata cgctcttcac ccgggaattc agcttcacgg ccgccgctca taaagaacgt 2908621 gacgtgcgga tacttttcag tttctgcaat tcgaagctgt tttaacccgt gctgagataa 2908681 tacttctccg actgtgttat caagatttat cggtttaaac gctacatagc cgtcaactgt 2908741 ttcactgaag tgagtcaggc agacgaaata caggttcttt ggataattct cgccgcggtc 2908801 gaagtcacgg aagtctttgt ttgtgaacgt gttggaaatc tggatggcgc ggtccggtct 2908861 gaaattatag aaaatcacag aatcgccgtc ttggattttc gcaacaggct caccgttttc 2908921 ttttgtgatg acagatggaa tcacgaattc atcgtagata ccatttgcat atgaatcatc 2908981 aacaacatcc agggcgctgc ggtaagatgg gccttcgccg tacgccattg cgcggtacgc 2909041 tttttctaca cggtcccagc gtttgtcgcg gtccatagag tagtaacgtc cggaaatgct 2909101 ggcgatttca cctacaccga tttccttgat ttgatcgttc aactggttga tgtacgtttt 2909161 cgctgtctgc ggacctacat cacggccgtc aaggaagcca tggatataaa cctttgtcag 2909221 cccttctttt ttcgcaagct ttaacagtgc gaataaatga ttgatatggc tgtgcacgcc 2909281 tccgtcagat aaaagaccga acaggtgcaa ggctttgttg ttttctttcg cgttgctgat 2909341 cgcgtcaagg aatgtttgat tgcgttcgaa ctctccttca cgaatggcaa catttacgcg 2909401 tgttaagctt tggtacacaa tacgtcccgc accgatattt aagtgaccta cttcggagtt 2909461 ccccatttgc ccttcaggaa gacctacagc ctcgcctgaa gcagtcaaag tttgatgagg 2909521 atactggttc caatagcggt caaaattcgg ttttttcgct aaagcgactg cgttccctac 2909581 tgtttcgtta cgtaatccga acccatcaag aatgatgagt gcagctggtt ttttactcat 2909641 attgaccttc ctccaataat tgaacgaatg actgtggctc aaggctcgcg ccgccgacca 2909701 aagcaccgtc aatatcggac tctgccatat attctttaat gtttgcaggc tttacgcttc 2909761 cgccatattg gatgcgaagc ttgtctgcag cttcttggct gaagctttca gcgacggttt 2909821 tacggatatg cgcacacacg tcattcgcat ctttcgctgt agaagatttg cctgttccga 2909881 ttgcccagat tggctcatac gcaataacag aagcagcaac ttgttcttca gaaagaccag 2909941 caaggccttt tttcacttgg tcagcaacaa gatcatttgt tttgccggct tcacgctctt 2910001 caagcgtttc acctacacag atgatcggca caatgccgtg tttgaaagct gcgtgtgctt 2910061 ttttgttaac tgtttcatca gtttcagcga acatttcacg gcgctcagag tggccgatga 2910121 cgcagtagtc aacgccaagg tctttcagag caaccgggct gatttcgcct gtgaacgcgc 2910181 cgctttcttc gaagtgcatg ttttgagcgc cgacttttag gtcagtgcct ttcacagcag 2910241 aagcaagctt ttctaagaaa agcgctggcg cgcaaacaac agcttcagct ttgtctgctg 2910301 ctggaatgga agatttcact tcttcaacga agctgacagc ttcgccgagt gttttgttca 2910361 ttttccagtt accggcgata attggttttc tcatctgttc cacttcctta tagcagtttt 2910421 gagattattt atcgttcagt gcagctaccc ctggaagctc tttgccttcc ataaactcaa 2910481 gggatgcgcc gccgcctgtt gagatgtggc tcattttgtc agcaaggccg aatttttcaa 2910541 ccgctgccgc agagtctcct ccgccgatga cagagtatgt atctttcgcc tctgccaatg 2910601 cttccgcaac cgcttttgtt ccttgagcga acaagtcgat ttcgaatacg cccattggtc 2910661 cgttccacac gacaagtttg ctgtttttga tgacgtcagc atacgtttcg cgtgttttcg 2910721 taccaatgtc gattgcttct aaatcactag ggatttcaga gatcggcaca attttcacgt 2910781 ttgcatcgtt agagaaatca tctgcaacga gtacatcttc aggcatgtag aagttaacgc 2910841 ctttttcttt agcgcggtcc ataaatgatt tcgcaagctc gattttatcc tcttcaagaa 2910901 gagatttccc gacttcatag ccaagcgctt ttacgaaagt ataagcaaga cctccgccga 2910961 tgatcaggtt gtctacttta tcaagaagac tttcgattac accgattttg tcttttactt 2911021 tcgctccgcc gatgatcgct gtgaacgggc ggtcaggatt ggaaaccgct tttccaagta 2911081 catcaagctc tttttccatt aagaaacctg caactgctgg cagatgctcg gcaattccag 2911141 ctgtagatgc gtgagcacgg tgggcagcac cgaatgcgtc atttacatat acatctgcaa 2911201 gctcagcaaa tgcttttgca agctcaggat catttttctc ttcaccagga tagaaacgta 2911261 cgttttccaa tacaagaacg tctccgtcct tcatctcaga aatttgtgct tttacagcat 2911321 cgccgtatgc ttcatccgct tttttcactt ctttgccaag cagttcgccg agacgtgcag 2911381 cgacaggagt taaacgaagc tcctcaacca cttcgccttt cgggcggcct aagtggctcg 2911441 caagaaggac ttttgcgcct tggtctgcaa ggtgtttgat tgttggaagc gcagcacgga 2911501 tacgtgtatc gtctgttact tccccgtctt tcattggaac gttaaagtca acgcggcaga 2911561 atacaacttt gccttttacg tcgatgtctt tgagagtttt tttattcatg cctaggagat 2911621 cctccttcaa aatggtttgc atacagcacg aaaaacgtga aaccgtctgt tcaagcgata 2911681 actccgctag ggcagatcgc agtctttttc ggcacagggc agttcgtcta aaagccaggg 2911741 cagcggcctt aggcgaaagc gccggcaaag ctgcttaaaa cgcggtcgtt tctctatcac 2911801 agagcgtttt ctgaaagccg gtcttcatgg aaaaagggaa agggagtccg tccccttccc 2911861 ttgtccgctt tcattatagc gcttctattc gaaagaacca agtcaggtcc tttttcagct 2911921 ataaattaaa gacctttttt tgcgatgtaa gctgcaaggt caacaacgcg gttagagtag 2911981 ccgctttcgt tatcgtacca agagattact tttaccatgc tgccttccat aaccattgta 2912041 gaaagagcat cgattgtaga agagtttttg tttccgttgt agtcgccaga aactaatggc 2912101 tcttcgctgt agccaaggat tcctttaagg tcgccttcag ccgcttcttt aagagctgcg 2912161 tttacttctt cagctgttac ttcttggttc agttcagcaa ccaagtcaac tagagaaacg 2912221 tttggagttg gaacacgcat tgctccaccg ttcagtttgc cttttagttc aggaagaact 2912281 agagaaactg ctttagcagc accagttgat gttgggatga tgttttcagc tgctgcacgc 2912341 gcacgacggt agtctttgtg cggaagatca aggatttgct gatcgtttgt gtaagagtga 2912401 acagttgtca tcataccgcg tttgatgccg aatttatcgt taagtacttt tgcaaacggc 2912461 gcaaggcagt ttgttgtgca agatgcgtta gagataacat cgtggttagc cgcatcgtat 2912521 ttatcttcgt taacacccat aacgattgtg atatcttctt cgttagcagg agcagagatg 2912581 attacttttt tcgcgccagc ttctaagtgt ttcgcagcgt ctgcgcgttt tgtgaagaaa 2912641 ccagtagatt caactacgat ttcaacgcct tgtttgcccc agctaagttt agcaggatcg 2912701 cgttctgcag aaacttcaat tgttttgccg ttaacaacaa ggttgttacc gtcaactgaa 2912761 acttcagcgt ctaattttcc gtgtacagaa tcatattgta aaaggtgagc cagcatgtta 2912821 gcatctgtta aatcgttaac cgctactacc tcaacttcag gattgtttaa tgctgcgcgg 2912881 aatacgttac gtccaatacg accaaaaccg ttaataccga cttttactgc catgattgtt 2912941 tcctccttta aataagtgag agatatttat attgagggat tattcatccc ttaataactt 2913001 ctttgcggct ccttcgtctg tgacgagaac cgtgttgcgt ggctttttaa agtaagcctc 2913061 gatcgcttcg gcttttgatg atccgcccgc taccgcaata atatcgggga tggcgtctat 2913121 gtcatccagc tgcattccga cagaatgcac tttgtgaacc acttcgccgt ccgcgttaaa 2913181 atagtagccg aacgcttccg tcaccgcgtc gttatcatct attttcttta aatcttctaa 2913241 aggcgtgttt ctgcgctgag ccatagtttt agcttcgccg attccgtgaa ccagcatact 2913301 cgctgattta atggtgttca gcacctcttt gacagaaggc tcttcaataa tagatgaata 2913361 ggcgccttgt gacagctgtc ccggaacaaa caaaagccgg taagtgcctg aagccttctc 2913421 cgccatatgc gcgcatatgg tgttcgcctg gtttttcacg tcttcgccta aaccgcctct 2913481 tgcaggcaca aacaaaagct cgcggttttt agaatccggc gtcatcattt cggcgacagc 2913541 ttcaattgtc gtaccgccag ttacagcgac gatatttttg cctgaaaatc tttttttcat 2913601 acatgcgaca gccgctcttc ccatttcttt tttgacccat ggggattgat cgctgtctcc 2913661 ggatacgata atggcatcct ttagatttaa acgttctttt aatgtctttt ccaaaagagt 2913721 caaacctaaa acatctttca tcgtatcttc caaaacagaa agcagttcat agccctcttc 2913781 tgtcaatgtc atgccgtttg tcttaatatc gaccaggttc tgttccttta aaaactgaac 2913841 ctcgcccctc agcacacgct cgctgattcc gagactggca gacaggcttc ttcgcccgat 2913901 gggttctgtc agcctgatat actgcaagat ttcaaacctc ttttgcataa cgagcagaag 2913961 atcaggcaat aatttttttt gagcttgtat taactggttc atgactcaaa cgttccttcc 2914021 ttttttgctg gacattatat gtcccgctat gacaaaaaac gtcccgtcat agccaaaaaa 2914081 aatcatttct gctttcttta attattttaa cagggtggaa ttgtttattc aactgttaag 2914141 agccaattca tcgacaatat tcgcagagtt ttcatgccgc gtcgttttat ccagcaatat 2914201 tttatcctat atatctttat cttatacaga aagcgccaaa tggtgcatcc caatataaac 2914261 agcccttccc gtagaaaggg ctgtttcatt aaagcgtttt cattttatcc aaagcttttc 2914321 aatttcctcg agcgatttgt tcttcgtttc tggacagatc gtaacgacaa acaggaaaca 2914381 aaggatgtta atcaccgcaa agatccaaaa tgtataggcg agcccgaaag aatcgatcat 2914441 cattggcaca aactgtccga tcgcccagtt tgctccccat aaaaagatgg tcgcaatgcc 2914501 cgcggcccgc gcacgcagat ggttcgggaa gatttcagaa atcataatcc atgtgatcgg 2914561 tccgaccgag acacagaaag cagcgacaaa acctaatata aggacgatca tcatgatccc 2914621 gcttgttaac tcaaaataaa acgacgtccc gattaaaatc ataaaaatag ccataaaagc 2914681 agaaccgatg gacatcagtt tttttcgtcc gactttatca atcagcaaca ccgcaataac 2914741 ggtaaaaata acttctacaa ccccgacgat acaagtcgtc acaaatccgg cgttttgccc 2914801 gaatcccatc attttaaaga tttccggccc gtagtaagta atcgcgttca tgccgatgac 2914861 ttggttaaac agcgccagca ggattccaat gacaagcgcc tttctgagac ccggcttaaa 2914921 cagctgggag agcgacccca tttgttctat ttttaaagag ttctcaatgt tctttaattc 2914981 ttcttttgca acagtttctc cattaatacg tgtcaggatc tttaaagctt catttgtttt 2915041 gcccgctttc gccagccatc tcggactttc cgggacgacg agcaggacaa ggaaaaaaat 2915101 gacggatggc accattccat aagcaagcat ccatctccag ccggtgtgca cgccccattc 2915161 gtatgttccg gaccgctgca cagctagatt aataaagtat gttgcggaaa tacccagtat 2915221 cgtaaagagc tgatataacg aagataaact tccgcgtata gcgggcggtg ccgcttctgt 2915281 aatatacgta acagagagcg atgagcccat cccgattccc agccccccga taatccttgc 2915341 aatgattaag gtggacacgt cttgagaaag cgctgaaacg attgctgata tcgcaaataa 2915401 caaagcggct gtcattaaaa tttttctccg gccgaatctg tcacttaaaa atccggatat 2915461 cccgacgccc acaactcctc caatcataat gcttgaaatg acaagtccct ccataaacgg 2915521 actcaggctg tataaatctt tcagaaaacc gatggcgcca gaaatcactg ccgtgtcata 2915581 gccatacaat aagccgccaa gccccgccgc acatgagatc aaaatgacaa atcccattga 2915641 atggcttctt gttacaggaa catttggttc taattgagtt ggagtattct tcatttccct 2915701 gccctcccga atgttgagta aagcgttttc atttaaacct tcaattgtac gtacttatat 2915761 taaaatttaa cgaaaattac atttaattag tacgtacaaa tatagaataa tcttgtttgc 2915821 attttctgtc aatgttttct tacaaagaac gctgtgatat actgaaattt gtccgtatac 2915881 attttggagg aatggatatg ttaccaaaat acgcgcaagt aaaagaagaa atcagttctt 2915941 ggattaatca aggcaaaata ctgcccgatc aaaaaatccc taccgaaaac gaattaatgc 2916001 agcaattcgg cgtcagccgg cataccatcc gcaaagcgat cggagacctc gtatcacaag 2916061 gtctgctgta cagcgtgcaa ggcggaggca cctttgtcgc ttcacgctct gctaagtcag 2916121 cgctgcattc caataaaacg atcggtgttt tgacaactta catatcagac tatattttcc 2916181 cgagcatcat cagaggaatc gagtcctatt taagcgagca ggggtattct atgcttttga 2916241 caagcacaaa caacaacccg gacaatgaaa gaagaggctt agaaaacctg ctgtcccagc 2916301 atattgacgg actcatcgta gaaccgacaa aaagcgccct tcaaacccca aacatcggct 2916361 attatctgaa cttggagaaa aacggcattc cttttgcgat gattaacgcg tcatatgccg 2916421 agcttgccgc gccaagtttt accttggatg atgtgaaagg cgggatgatg gcggcggagc 2916481 atttgctttc tctcggccac acgcatatga tgggtatttt taaagctgat gacacacaag 2916541 gcgtgaaacg gatgaacgga tttatacagg cgcaccggga gcgtgagttg tttccttctc 2916601 cggatatgat cgtgacattt acaacggaag aaaaagaatc aaaacttctg gagaaagtaa 2916661 aagccacact ggagaaaaac agcaagcaca tgccgacagc cattctttgt tataacgatg 2916721 aaattgcgct gaaggtgatt gatatgctga gggagatgga tcttaaagtg ccggaggata 2916781 tgtctattgt cgggtacgat gattcacatt tcgcccaaat ctcagaagtg aaactaacct 2916841 ctgtcaaaca tccgaaatca gtgcttggaa aagcagccgc caaatatgtc attgactgct 2916901 tagagcataa aaagccgaag caagaggatg tcatatttga gcctgagttg atcattcgcc 2916961 agtccgcacg aaaactgaat gaataaaaaa agcaatgtat gggtctcccc gctacattgc 2917021 tttttttata gctgttatct gtttttccaa acgtcagcga tgatttcaaa cgaacgcatt 2917081 ctgtctgcgt gttcaaaggt ttctgagtta accataattt cgtcagcctg tgtcgttttg 2917141 acgaaatctt caagcttcgc cttcacttct tccggacctc cgacaatcgt ggagctcagc 2917201 tgctcattga ccatcgcttt ttcatacggg ctccagattt ggtccatatc ctcaacaggc 2917261 ggtttaagct ggttaggcgt accgcggaca agatcaagaa acctttgata atgggaagtc 2917321 gcaaggtgct gcgctttctc gtttgtatct gccgcgataa tggtgacacc gaccatcgca 2917381 tacggttcgt cgagcacgtc tgacggcgtg aaggaattgc ggtacagctc caaagcggga 2917441 accgtattcg ccggtgagaa atgggccgcg aacgcaaacg gaagaccaag ttcgccagcc 2917501 agacgggcgc tgaagccgct tgagcccagc agccaaatcg gcacatctat gccctctccg 2917561 ggaatggcgc gaacttgatt gcgcacattt cctgacggtt taaaataatt gcgcagttcc 2917621 tctaattgtt ctggaaaatc ctccccgctg ttgatgtttc tgcggagcgc tctggctgtc 2917681 aattggtctg ttcccggcgc acgtccaagc cccagatcaa tccgcccggg atacagtgtt 2917741 tccagtgtgc cgaattgttc agcaatgact aatgaagagt ggttggggag cataatgccg 2917801 ccggaaccga cgcggatttt cttcgtgcct ccggcaatat ggccaatcaa aactgcggtg 2917861 gcagagcttg caacaccttc tatattatga tgttcagcaa gccagtaacg gtgatagccc 2917921 cattcctctg cccggcgcgc caagtccatg ctgtttcgga atgattctgc aatcgttcct 2917981 ccctgaacaa ccggagataa attcaagaca gaaagcaagg tatctttgcg ttggttgtta 2918041 gacatattgt tctcctttgc aaatgtgtta tcagtaaaca gcccaaagct gtcaggtcat 2918101 gattgaaaga acttctatca caccataaca caactgcatt caggaataaa agaatttgat 2918161 tcgatgaaat tcgaacaata taaaacgaac ggtttggaac attattctgc tccaaacaac 2918221 tccttagcca tctcaataaa gagcttagcc gccagagaag cctcctttag cgacggaaca 2918281 gcaagctgca catcacggta tacctgcggg tccaattccc tggtcaccac atgctctggc 2918341 agcggcatcc ccgacatgga catttctgat aaaatggcca ggcccaggcc ttctctgatc 2918401 atactgatcg aggtgttgat gttatagacc gtgaaagctg ggtgcagcgt agcacccgcc 2918461 tgcctgaaca tatcgataaa tggtgattca tagccgccgt cacagacgat catcggttca 2918521 tggtcaagat ctttcagcgt aatggctgaa tgactggcaa gcgggtgatc gtccctgagc 2918581 acgacagcca ttttgtcttt tttcaaatga atgtactcca tctcctctgt tggatacaga 2918641 agaatcccaa catctatcat ccgcgtatga agccactcct tgacttcatt tacagttccc 2918701 tcgtgcagca cgagctcaag tttcggatat ttttgtttaa attcactgat cagcttcggc 2918761 ataaaataag ccgaggcagt tgagaatgtg ccgatatgga tcgttcccag ttcaagccct 2918821 ttttccgctg ctgctacctg ctcaactttt tcaatgcctt ttaagacttc tctgatgtgt 2918881 actaagatct gttttcccgt atccgtcagc atcaggccat tgcggcggtc acgaatgatc 2918941 agctttacat caagctcagc ttcgatcgca gaaatcgcat ggctgacagc cggctgtgtc 2919001 atgttcagcg cctgacccgc ttttgtaaag cttcccgttt cagctatttt cacaaaaacc 2919061 tttaattgag taatggtcat aacaatttac ttatgctcct tataaaaaag attcatttta 2919121 tttatcttat gttctaccgt atcatatgat ggaaaagttc tacaaggagt gaatgaacaa 2919181 tgaagcagct cccaaaaacg cggacagctc tcctgctcgc atttctcgtc atcatgtggg 2919241 gcgtcaattg gccgctgtcc aaagccgcgc tcgcctattc tccgccatta ttgttcgcgg 2919301 gcatccgaac gctgatcggc gggcttttat tagtcatagt cgcactgccg cgtattcata 2919361 aattacgctt aaaagaaacg tggccgattt atcttgtttc tgctctttta aatattacat 2919421 tattctacgg cctgcaaacg atcgggctga attatcttcc ggccggcctg ttttctgcaa 2919481 tcgtcttctt ccagcctgtt ctgatgggtg tattttcttg gctgtggctc ggcgaatcca 2919541 tgtttgtaat gaaagtgatt ggcctcatcc tcggttttgc gggagtagcc gtcattagtg 2919601 ctgcgggctt tggcgggcat atttctgtca ttggggttct gctggctctc ggctccgcag 2919661 tcagctgggc gctcgggaca gtatatatga aaaaaacagg cagccgcgtc gattccatct 2919721 ggatggtcgc tctgcagctg acgatcggaa gcgtgtttct gcttatctcc ggcttttgga 2919781 cagaaagctt ttcggcgatc caatggacag ctccgtttat tacgagcctg ctgttcatct 2919841 ccgtattcgt tatcgcactc ggctggcttg tcttttttac gcttgtcggt tcaggagaag 2919901 caagcaaggt cgcatcttat acttttttga ttccgctcat atcaatcgtg gccagctcca 2919961 ttttcctgca tgaaccgctc acccttagcc tcttggcagg gctgctgctg attgtcacga 2920021 gcatctgtct cgtgaataca aaatcaaaag cgcagaaagc tgcggcgatt ggtataaacg 2920081 agaaagctgc acaataataa aaaccctctt gccggatgcg gcaagagggt ttcttattta 2920141 ctgatgcttg cgtcctttga ccaaatatgc aactgtaatc aaaaggtaga tcgccgcagt 2920201 aatgccggta atgacaattg atgttgtcat gatgaccccg atcagaatgg cgagtaatgc 2920261 cacaatcgca aaccatgtcg tgtacgggaa ccattttaca taataggccg gtgtttccgt 2920321 ttgctgtttt ctcgatttta aatgagcgaa tccgatgatc agccaaatga ataaaacggt 2920381 atatcccaat gatcccatta aataattaaa tgtttggctt cctgcgaaca gagaaatcaa 2920441 tacgccaata tagagagaag aagtgcacat cagaatcgca aacatcggta cgtttttcga 2920501 tgaaagcttc gagaagacct ttggaagcct tccgtcactt gcctgtgtat acaaaatgcg 2920561 tgatgatccg tataaacctg aattcataga agaaatgatc gccagcagga tgactgcatt 2920621 catgatatga tccgcgcccg gaatgcctac cattttaaag accatcacga aaggactttc 2920681 cggaacggaa ttgacttggt tccatggaat caggctgacg atgatgaaaa acggcagcag 2920741 gtaaaacgcg acaatccgtg tcagtgtgct gcggacagct ttcgggacaa ccttttccgg 2920801 attttttgtc tctgcaagcg ttacaccgat aatttctgta ccgccgtaag agtagatgac 2920861 gacaagcatc gccgtgatca gccctgtgcc gccgtgcggg aaaaatccgc cgtggtctgt 2920921 caggttggaa aatccggatg ctgtatgatc accgaatgat acaaataaga gcagcaatcc 2920981 cagaataata aagataataa taacggtaat cttgatcatt gccagccaat attcagtttc 2921041 ggcgaagatt ttaacagaaa gcaagtttac aatcgtgacg ataagagaaa ttcctaatgc 2921101 caacacccag atcgggcagc ccggcagcca atattgaatg aaaatcgcag ctacaacagc 2921161 ttcagccgca atgttaagca cccacatttt ccagtagatc cagtccaaaa agtaagcagc 2921221 gtaatttccc aatacctgct ggacaagatc acggaaggtt ctggcgttac ggtttcgaac 2921281 agccatttcc gccagcccct gcataataaa cagcaaaata atcccgccga gcaggtatgc 2921341 gataatgaca gatggccctg ccacatcgat cgctgagctg ctccccttaa ataaacctgc 2921401 gccgattgct ccgcccagcg ccatcatcat aatatggcgg gacgtcatcg tgcgttttaa 2921461 cgtttgattg tcgtttttca tcctcttcta cctctccttc tcgttttcaa aaacaaaaaa 2921521 gcccgccgtc tcctacctaa tctaatagat aaagagacga cgagccttcg gctgaccgcg 2921581 gtaccactct tgttgattct tcatgaagaa tcctgctttt gacctgtaac gaaggttagc 2921641 cgttaaaaca tagggaatat tcaatctatt ccgttccgtc ttaccactcc cgggcgagtt 2921701 caaagaagaa tcaggctgcg tcgcaccacc ccgcagctct ctgttctgat cactttcttt 2921761 tactgctccc aatctatgtg ttttagtttt ctgaaaaact caaattttat gatctgaata 2921821 tattaacata atatacgtgc ttctctttta actgtcaata acttcagaga aaaaagaaac 2921881 tgttattttg tcccttttcg aatggctttc caaaaggatt ctgactcgtt tcctaatgcg 2921941 taaactgaaa cacctgctat tttatattgc tttgccagat ggcttttcgt ttgaacggtt 2922001 ttttcgtttt cataccacac gacatgttta tgcttctttt tgtcaacata agaaaacgtc 2922061 atcgagcctg attttttgtt gaatgccggc tttgcttttt gttttttgat gagggatttg 2922121 agctcattcc attcccttat tgtgctggta cttccgtctt ttacatccca gtcatagccg 2922181 tacgcaggga ttcccatgat gactttattg gctttgatct ttttgactga aaactgcaga 2922241 gagcttttga tccagtttgt gcttgccact gaccccggct caccccaaat gccgtgttca 2922301 tcgtaggtca tgacttgtac gaagtcggca tatttgccga ttttcgcata atcatacggc 2922361 cagctccagt catcattttt atcatcggcg cttttggccg gaacggatac cattgtttta 2922421 atatgtttct tattcaaagc ctgtgagaca tattgaatga agttcgagta tgcagcgcgg 2922481 tcttctggat ttactgcttc aaaatcgata ttgattccgt aatatgagtg ctttttggcc 2922541 agtgtaatta actgatctgt gaatcgtttt ttcgctgttt tattgctcat gacccgactc 2922601 gctaaatctc cgtcaaaatc ataaatggca tcattatagt ttgaaatgac agcccatgtc 2922661 ttgatttttt tctttttcgc atatgtcagc tgcttagttg gggcatcgcc aatgatttgt 2922721 ccgttttttt caaacgcaaa tgtatcggtt gcgatggcat tcatgtatgt atgatatttc 2922781 gtaagagaat tgtatgaagc cgtatcccca gtcgtgtagc ctactgtcat accggctgcc 2922841 ttcgcttctc cttttgtata cataaacaga acaatcgcaa tcgccagtga aaccgctatg 2922901 atcagccatt ttttcatcgc atttcctcct gtatcaagtc atactcttct catcggccaa 2922961 aaaattggaa gttgaagttt tttcaagcaa aaagcccggc atatgcctgc cgggcttcct 2923021 gagttcagcg gtcagagacg agaatatatg ctgcctttac tggtccatgc acccccacaa 2923081 ctaaatccat ttcaatgtcg gctgagttac tcggtccggt aatgtagttg atacatgaag 2923141 gaacagtgac accgttcgca atgttttggc ggatgatatc actggcttgt gtcattctcg 2923201 gtacaatgct tgatttcggc acgatcgcaa tataagtcgt tggcaaaagg ctgacagagc 2923261 ggccgatgtc ttttgaggag aagaggacaa ccgtccccga ctcagccaat gtaatttcgc 2923321 tgaatgtaat ccctacattg gcttgctccg cttttttaat attttcctcg cctttgtcag 2923381 catcccactc ccagaccggc gttccttcac tcggccagtc cttggtgagc aggcttttca 2923441 gtccgtattc ttcaaagcgg gggtccttcg gaatgatgac agggcctcca gaaaagcggc 2923501 tgacttgctc gcgcagggca tcgtaaaggc cggttgaatc cgtttcaatc agctctgtat 2923561 ggattttgac acaatggttt ttgagcactg tgactaagtc atccgctgaa taaccttcaa 2923621 gtgttttata ttgcggctga tgcgcccatt cagggactgc cacgcctcct gttcttcgtt 2923681 cacggcccag gctggatgcg attcggttta aaaagctctc ttgattctga atggttccct 2923741 tcgtcatcac tgctcctcct tcgtgcgttc acttgtttct ctgtccgcaa accagtctct 2923801 gaatctcgat ttatgcggtg ccgggaagtc gcgaatctgg gtccaatttt taagcgggcc 2923861 gggccctttc gaaatttttt cgtcctctgt aaaaggcgtc atggcggccg gcgcccattt 2923921 tgagcccatt ttgtaaagcg ataaggagga tgcgccaagt ccgaatgctt tcattgcaag 2923981 cttttcactg atcggcgccc tgccttcttt ttcgacgata ttctgacgat gcttgagtag 2924041 cagctcatga agcgggattt tgaccgggca ggcttctgaa caagcagcgc acagtgaaga 2924101 tgcgtacggc agctccttat aatcgtcata accgccgagc aacggtgata aaacagctcc 2924161 gatcggcccc gagtagattg agccgtatga atgtccgccg acatggcggt acacaggaca 2924221 gacattgata caggcggcac agcggataca ttgcagcaca gactggaatt ccgttccaag 2924281 gatattggat cgtccattat caacgatgac aagatggaat tcttccggac cgtccacttc 2924341 accttccagc ttcggacccg tcaaagctgt aatatagctt gtcagccgct gtccgacagc 2924401 acttctagtc agcatgctga ctagcacttc aaattcagaa aatgacggga caatccgctc 2924461 cattcccatg acggtaattt gtgttttcgg caaggtgctc acaagccgtc catttccttc 2924521 attggtcaca aggctgacgg aacccgtgtc agcgatggcg aagttacagc cggtaatgcc 2924581 gatatccgct tccagaaact ttttccggag aatggcgcgc gcatgcatca ccagctcttc 2924641 cggtttttct gtatgttgat agtccagtct ttctttaaac acatcgcgta tctgctcttt 2924701 atttttatga agagcgggcg ctacgatatg tgacggcgga tcgtgatcat caatctgcaa 2924761 aatatactcg ccgagatcgg tttctacgac ttcacagcct tccttctcca gcacctcatt 2924821 cagattgatt tcctctgtga ccattgattt agatttcaca attttcttcc cgttcttctt 2924881 ttgaatgaca tcccgaatat aggaagacgc ctcttccgct gttttcgcga aatagacatg 2924941 tccgcctctt ttcgccacat tttcggcaag ctgtccgaga tagaaatcaa ggttttcaag 2925001 gacatgctgc ctgatttcct ctgataatga gcgccactcc tcccagtttc ccagttcttc 2925061 tgctgcctct aggcgccgcg tccgcagacg ctcctgtgca cctgaaacag cgcctctcat 2925121 aaattcatta tcaatcccct gtgatacccg ctctttaaaa gcgtcagtac cgattttcat 2925181 cgccatgatc ctttccccct ctgaatccag ttttatctgc tgttgagcac ttcggcgatg 2925241 tgcatcactt tgacattctt atcttttcgg ccaagccgtc ccccgatatt catcaaacag 2925301 ccgcagtcag caccgatcag cacctctgct cccgtttcct ccacacattc gactttttca 2925361 tcgaccatct gctcagaaat ctgcgccatc ttgactgaga acgttcctcc gaatccgcag 2925421 cagttatgtt tgcccggaag ctctgtaaac tgcaggccct tcacatggct caacagcttc 2925481 atcggctcct tccgaacacc cagcagccta gtcatatggc acgacgtatg taaggtcgct 2925541 tttgtatgaa gggtcgcgcc gacatcctct accccaagga cgttcacaat aaaatctgtc 2925601 agttcatacg ttttatccgc cagctttttc gctttatcgg cccatttcgg atcatcctga 2925661 aacaggtgcg gatactcccg gaacatcgtt gtgcaggaac ccgaaggact gacaacatat 2925721 tcggaatcct gaaacgtttc gatcatccgt ttcattgctt ttttggcgtc atgtacatag 2925781 ccgctgttgt aagccggctg tccgcagcaa atctgccctt ctggaaaatc aacctcgcac 2925841 ccaagccgct ccagcagctc aaccgttgct tttccgacat ttgtttgaaa catatcaaca 2925901 agacaagtga caaaaagtga gactttcatg atgaacccct ctctcatccc caatatatga 2925961 tcaggtcatc tgatgacctg agttaaaata actatatgaa tatcgtacac tattctgaca 2926021 atggaaggaa agagttttct agggatattt tcatttgtgg catatcaaaa acactcccga 2926081 tctcccagga gtgcagtata tggttagatc cagccctttt cctcagcgat gctggcggct 2926141 tctgtccgat ttttcgcatt aagcttttgg atgatttctg agatatagtt tcgaactgtg 2926201 ccttgagata aatagagctc cagcgtaatg tcttttgttg tcttgcctaa agccgcaagc 2926261 ctcagaattt cttgctctct aacggttagc ggattttcgt ctcgcatcat attaaacgtc 2926321 agctcagggc tgaagacacg ttttcccttt acacattttc gaatggcatc ggccagatcg 2926381 tcaatttcac cgtctttcag cagatagcca tgtgcaccgg cctttacggc gcgttcaaaa 2926441 tatccggggc gggcaaaggt ggttaaaata atgaccttgc tgacgcagcc ttttttcatt 2926501 aattcctctg ccacattcag cccgcttcga accggcattt caatgtccat aatgcataca 2926561 tccggctcca gcttcaaaat agcatgtagc gcctcttccc cgtttaatgc ttgtccgatg 2926621 actgtcatat cctcttctaa atcaagcaaa gatcccaaag cgcctaaaag cattcgctgg 2926681 tcctcagcaa taaacagacg aatcattctt ttcgtcctcc aatcattctg cttttttaat 2926741 aagcggaatc gtcagtgcca caaccgttcc gttatggtct gaaaccgtta atcccccttc 2926801 aatgagcatg agccgttctt ccattcccca caggccattc ccaaacattt tctccttcgg 2926861 cgctcccttt ccgtcatccc gtattacgat cctcattttg tcagcaaatt gagaaatggt 2926921 gatggcacag tgggttgctt tgctgtgctt gataatgtta gtcacggctt cccgcataca 2926981 catactgata atattttgag tgacgggaga tatcactgaa aagtcgtcgg ctccttcgta 2927041 ttgaaaggta atgttccccg ctcttaatat gtgctgaatg tttacgagct cctctgttat 2927101 cgtgaccgtt ctcatatcag aaaccagctc tcgaacttgc ttgagtgcgg agcgtgaact 2927161 ggtttccatt tcttttgcct caagcttggt ccgttctgga tcagatgcag ccagccgctg 2927221 aatgagctgg ctttttaatg taagcagcga cagggtgtgg ccaagagtat cgtgaagatc 2927281 acgggcgatt cgaacacgtt cctccctttt agagagttct tttatctgtt cgttggcttg 2927341 tgcaagctta gcttcaagct caatcctccg aaacatagaa cgaattccga atggagaaat 2927401 gagcataatg acgagaaacg ggagaacaga aaaaagctcc cgaagcgaga ccgaattcgc 2927461 gataaattgg tataggcatg gaaaaagcag tataaagatt aaagcgcaga acgcacggtt 2927521 aaaattcgtt ttctctttgt aataaccaac aaagtttgcc ggaaaaaaac ctaagtatat 2927581 ataggtgata ttgtaaaaca cactatacat caaaataacc gccatttgca cgataagcca 2927641 atatgtaaac gaagctttgc ccacgctgca gaataactgg cgatatgccg ctacaaaaag 2927701 gagcagcata ccatatccga tcccctgttt gacccctgat tcttttaata aagagaggaa 2927761 cggcataatc gtatacacca gaaagatata agggaaaaac ccgaattcct tcgggaaaat 2927821 agatattgcc tttttcatgt attacaccgc ttcttgtttt cttcttatat atttagatag 2927881 tagcatgaag agcatcatat aagcgattaa tatcagaata tttttccaag tcggactccc 2927941 accccggaca agttcccacg ctccgctccc gaaatgataa gacggaagcc actggccaat 2928001 gctctgcatc atgtcaggca tgacctcaaa cggcatccac atccctccgc ctaaagccag 2928061 cagcatataa agcacattac tgattccggc cgctgtttct acttttctca tgaggccgat 2928121 tagtgtgcct aatgctaaaa aaggcaatgc gccaaacaaa atccacagtc cgctcatcat 2928181 ccattcaaac ggtgacaagg caatatcatt gatgattgcg ccgaacagaa atatgacggt 2928241 aattgataaa acgtgaatga cactttggcc gatcatctga gctgataaat agatatgatc 2928301 cggaagaggc gtaaggcgga taaaggcggc ccagccttgt gaccgttctt gtaccattcg 2928361 gatgccaagc gtcatgatag aggaacccat cacgctgaag actgtcatcg acatcaggta 2928421 atgggcttcc catgcacgtt gatcagggac gttggtattc actacatttg taaagaaata 2928481 ataaaaggca atcggcatga tcagagacca aagcacaaag tacttgttcc taagcaccct 2928541 tttcatttca gcgatgcttt gcttttgcag cacgttcact cacatcgcct ccctgttgcc 2928601 gtcagccagc tggcgaaatg cctcatcgag cgttgcttgc tcaattcgaa tatcccgtgc 2928661 atgtatgttt tcttgaaaga tcagcgccaa cactttgtct gtatttgatg tctggatgat 2928721 ggttctctca tgctcgtgga tcactctctc gacttccggg tgacaagaca gcctttccaa 2928781 tgattcactt gaatgaagcg taaaggaaac agactgtttt tgaattcttg agcggatttg 2928841 cattggtgag ccgtctgcaa caagctgtcc ttcagtaaaa aataggattc gctgtgcggc 2928901 atcatctgct tcctgtaaat aatgagttga aaaaataatc gtttttcctt ggtccgacag 2928961 tccgtgaatg gtctgccaga atcggtgtct tgatgaagtg tccatgccga ctgtcggttc 2929021 atcaagtata agcagctccg ggttcccggc aagagccaaa gcaaagctca aacggcgttt 2929081 ttgtccgccg gataattttt ctgctcttgt tttcaaatct tctttggtga gtgctgttaa 2929141 cgaaacgagt tctttcatgg acaatggatt cggataatag ctccggaaga gttcaaggat 2929201 ttcatccacc ttaaggcccg gcatgacact tacttcctga agcattacac ctattttttc 2929261 acgaacctgt tgatcatcgg gaacccggtt aaatagtttg atttctccct cactcggttt 2929321 cagcaatcct aatatcatcg agacgacggt cgtcttccct gccccatttg gcccgagaat 2929381 ggctgcaatt tctccttttt caatactgaa gctgatgttg tttacagcgg tttttcgctg 2929441 gaaatgtttt gtcacgttgc ttactgttac tgcttctttc atcacatgag cacctcctga 2929501 tcgtttacat tgattgtaaa atgacggaga agacgatgtt agtatggggt gtcatgatga 2929561 tggagtgaca aatgtcattt ttttctcacc ccggtgtcta ggcaatcctc ctcctgcatc 2929621 ttccaattca tccatctttt ctatctccca tgtcctcttt cttttaaact gctgtgacat 2929681 tcatagaaag atacactctt caaaccatcc gagtgttatg atagaaatat tgaactttat 2929741 attactttcc ggctgaaagg agccaatcat gaacgaagcg attttgtcta gaaatcatgt 2929801 gaaggtgaaa ggcagcggca aagcatctat catgttcgca cctggttttg gatgcgatca 2929861 aagcgtgtgg aatgccgtgg cacctgcctt tgaagaagat catcgggtga ttttatttga 2929921 ttacgtcggt tcgggacatt cagatttgcg cgcatatgac ctgaatcgtt accagacact 2929981 tgacggctat gcccaggatg ttcttgatgt ttgtgaagct ttagatctga aggaaaccgt 2930041 gtttgtgggt cactccgtcg gggccttgat tgggatgctt gcatccatcc gccgcccgga 2930101 gcttttttcc catctggtga tggtggggcc ttctccttgc tatttgaatg atccgcctga 2930161 gtattacgga ggatttgaag aggagcagct ccttggcttg ctggagatga tggagaaaaa 2930221 ttatatcggc tgggcgactg tatttgcggc aaccgttctg aatcagccag atcggcctga 2930281 aattaaggaa gagcttgaaa gccgtttttg ttctactgat cctgtcattg cccgccaatt 2930341 cgcgaaagcg gcgttttttt ctgatcaccg agaggatctt tcgaaggtaa cggttccctc 2930401 tcttattctc caatgtgcag atgatatcat cgcacctgca acagtaggta agtatatgca 2930461 tcagcatctg ccttatagca gtctgaaaca aatggaggct cgcggacatt gccctcatat 2930521 gagccatcca gatgagacga tacagctgat cggcgattat ttaaaagcac acgtgtgata 2930581 taggaacgaa agggatagag gtgaccctct tagatggaca aacaattgaa tgatgcacca 2930641 tgcggtttcc tcgctttgtc agaagagggg tcgatcatag ctgccaaccg cacccttatc 2930701 aagattctgg attatgaacc ggagcaggtt atcggccagc acatgaatat gatgttgacc 2930761 attcccgcgc agcttttctg ccagctttat ttttttccgc ttttgaaatt ggagcatcac 2930821 atcgaagaaa tatacatttc cctgaaagca agagatggag aagaaattcc cgtccttatc 2930881 aatgctattg cgagacacga tagcggggct tctgtctttg attgtgttct gattccaatg 2930941 cgaaagcgaa atgaatatga aaatgagctg ctgatagcca gaaatgaggc tcaggaagct 2931001 ttgcttgcca aacagaaagc caatgcggag ttagaaattg ccttggaaac gctgaaagca 2931061 aaacaagaag aacttcttga gatcaataaa caaaatcaac aatttaaatt aaacaccaaa 2931121 agagagcttg aactcgccag aaagatccag aaaaactcgt tgactgaacc gattgtaaac 2931181 gatcaggttc agattgactc ttattacaac gcatcgagtg aattgtcagg tgatctttac 2931241 ggatattatc aaatcgatga acaccgttac ggcattatta tccttgatgt gatggggcac 2931301 ggaatttcat ctgcattgat tacgatgtct cttcatcctt tgttccagcg ccagatcacg 2931361 caaggtctca gccccgttaa agttatgaag gaattggacc ggcaccttca cagcttgttt 2931421 caaaatgatg aggaagcaag acattattgc actgctattt atctcgagat tgatatagca 2931481 cggcaaagaa ttgattatgt caacgcaggg catccgccgg cactttggca ggacgatagc 2931541 ggaactcaac atctgcttca cgcgacctcg cctccgatcg ggatgtttga agacttagag 2931601 tttcagtcaa gcagcctttc atacacggag gacggaagat tgcttctgta tacggatggc 2931661 gtgatggatc ctacggcttc atgttattta tttgatttac taaaggatca tcctgattcg 2931721 ccaatcgctg acctgaagga gaaaatcctt acatcactgc agcatcaaaa ggaagctcat 2931781 cataagagtg atgacgaatg ttttatatta gttgatgtaa aataaaatga tccatgagac 2931841 ataacaatga tttgttacat ctcatggatt tttttgtttc agcgtttctt tggaatatgt 2931901 cctgactccg catattgaaa cacctgcaag gaaggcagcg ggtgtccatt aaaatcaaat 2931961 aaagcttgat tatctacagc acttccccca taccacttcc cggcgtcttc agggtcgtat 2932021 tcagcagcat agctggacgc ccaccctgac ccgtatgttt cccataacac tttgtttttc 2932081 tctatctgtg tcttcggccc gactggaatc cacgccggct cccagtagaa aacaccaagt 2932141 cctgctttgc ccgtattcgc cactgcctcc attacatctc ttactgcagt tgcctggcct 2932201 tgaacagaaa ttggatatgg caacgtctgc ccgctttttg gtgctgtatt tccatgccca 2932261 tcgccatcct cagcggtata ggtgtacgat gtctccgcca ccatgacttt tttgccgtac 2932321 gtattggcaa cagccttcag cacggaggtc aaattttgta atgtgccatg ccagaaagga 2932381 taataggagc tagcaaacac atcataatcc actttgtttt tgctgagtgt ttctgcaata 2932441 aatgaatacc ttccagccgt ttcaggattg gtaaaatgca gggcgaccaa aatatttgaa 2932501 tttgtctccc tgaccgctcg gcttccttca ttaaataatt ggcacatctt cgtccaatca 2932561 gtctcaccgg caaatcctcc tgttgtttca tttccgacct gaaccatgcc gatgtcaacg 2932621 ccttccttga tcatcttttg caggctttgt ttcgtatact catagagctt tgcttttttt 2932681 gcttcaaagc tgagattcgc ccaggctttg ggcacctttt gtttcgctgg atcggcccag 2932741 aaatcagagt agtgaaagtc ggccagcacc ttcattccgt tcgctgtcgc tctttttccg 2932801 atttcgatgg ctttttgaac atcattgttt cccccgccat acccgttgcc atttgaatca 2932861 tacgggtgat tccagatgcg gacgcgaaca tagttgaccc cagcctgttt taaagttgta 2932921 aagatatcct ggcgttttcc gtttgtattg taaaaggtga caccgctgtt ttccaaagca 2932981 ataacgctgg atacatctgc ccctttgata aaatccttgt tcatcccctc tactttttta 2933041 acaaaaagat cctctgcccg aagctctgac acgtgcttct ccttctcaat ggcagcggca 2933101 tatcctgttg aactacatgc actccacacg atggcagccg caaagaacat tttcactttg 2933161 cttttcatga tttcatcccc ccaagactta gcaagcgttt tcattctata gaaaaaagaa 2933221 tccgcccata tcgagcggag catcagccta atgtgtgttt acgacaattc tcacttcata 2933281 cttttccatc gtcaggtcgc ctgacaatat gtctcctgtc attatgtcct tcacactctg 2933341 atcaaacgtg accagctgtt tttcttccgt gaaattcatg acaaaaatat aatcattgtc 2933401 ctgatcctgc ctcgcttgta cggagacgcc ttttccgtgc cgaaccggaa aaactggaga 2933461 gagagacagg tctgtgatca gaccctcata gaaatcacgc tgaaattgat cctccaaacg 2933521 cgcgccgata aaatacgcct tgccctgctg atactcatgg cttgtgaccg ctggcgtgcg 2933581 cgcataaaaa tcttcttgat acaccgcttc cactgaagct gtctttacat caatcacggt 2933641 tgcataatcc ttcatttcat atatttggct gcggtagctg acagcgtttc gatccttcgg 2933701 atacagggtg tccgtttcaa gaggctcaac tccaaatata gcttgaagat ccggatgcca 2933761 tccgcctgtg tatgttaagt catgctcatt cacaaccccg ctgatatacg tcatgactaa 2933821 ggtgccgccg tcagccgtaa acgcttttaa acgggaaacg gtgtcctcgc tgattaaata 2933881 cagcatcggg acgatcagca gtttatatgg tgaaaagtct tgttctttcg tgatgacgtc 2933941 gacagggata tcgtgttccc agaatgtgcg gtaatgctgc tgaagcgttt gcggataacg 2934001 ttttgtcgcc ttcgcaaacc cctgagcatc ctcgagcgcc caatgatttt cccagtcata 2934061 taaaatcgcg gtttgagccg gcctcttcgt tccgacaact tcggacagcc gttccaatgt 2934121 ctcgcctacc ttggccactt cttgaaagac gcggttcttc gggctattgt catgatccac 2934181 aaccgctccg tgtaattttt ctgatgaccc ccgtgatttg cggtattgga aatagagaac 2934241 gctgtccgag ccgtgggcaa tcatttgcat ggatgacagc agattcatgc ccgggcgctt 2934301 tgccttgttg acgttatgcc aattgaccgc gcttggcgta cactccatta ataagaaggg 2934361 ctgctgcttc aagcttcggt acagatcatt gataaagccg accttcatcg ccaaatcagc 2934421 tgtgctttcc cagtcattgt gccagacagg ataagcgtcc cagctgatgg catcgacatg 2934481 ctttgcaaat ttgctgtagt cgaggccctg atacgggatc aaatccggtg tgtcagccat 2934541 aaaattcgtt gtgataggga tatcaggcgt caattctttc agcggaatga tttcattttc 2934601 ataaaacgaa atcgtttgat cggtgacgaa ccggcgccaa tctaaattca ggccatgcaa 2934661 gccattttca ccgatcggcg aagggctttc aatttgtgac cagtcattga acgtatggct 2934721 ccaaaaaggg gtccaccacg catggttcaa tgtcttgagg ctgttgtcat atttcgattt 2934781 cagccactcc cggaaagcat gctggcataa atcacagtgg caatctcccc cgtattcgtt 2934841 tgaaatgtgc cacattaaca gcgccgggtg atgtccgtat cgttctgcta ataagcggtt 2934901 gatgtgccgt gttttttctc ggtagacttt agatgtgagg cagtggttgt gccttccgcc 2934961 gtgcagctgt ttgacgcggg aggcattgac gcgcaaaact tccggatagg tttgcgacag 2935021 ccaggccgga cgggctccgc tcggcgttgc taatatgacc cggccgccta tactgtgaat 2935081 ccgctcaaaa atatcatcca gccattcaaa ttgatatacg ccctcctccg gctcaagtgc 2935141 gctccatgca aaaatgccga cagaaaacgt attcgtatga gaaagcttca tcagtttgat 2935201 atcgtcagct aaaatatcgg gccgatccag ccactgatcg gggttgtagt ctcccccatg 2935261 gagcataaat tttgcttttg ttacgtgcgt tttttcaagc tttgacatca cattctcctc 2935321 cttgttctct tagcccttcg ttccgcctgc ggttaatccg gacacaaaat tcttttgcag 2935381 cataataaag atgacggcaa ccggtatgct gataagcagg gctccggccg caaatgtcgt 2935441 atagctggcc cccatgacat cattcactaa attgaataga ccgacgggca atgtatatga 2935501 ttcaggcgtt ctcaatatgg ttgaggacag cacaaaatct ccgagcggac cggtaaagcc 2935561 gttcatggcc acgactgccg ccatcggttt tgataatggc agaatgatct ggaagaagat 2935621 tctggtgctg ctggctccgt caatcttggc gctttcgtct aaatccatcg gaatggaatc 2935681 catgtaccct ttcatcaaat acgtattcat cgggatcagg ccgccgatat aaagcaagat 2935741 tagcagccag tggctattga tcattcccaa gatttgcgcc agcacaaaca aggcaattaa 2935801 agctgaaaac tgaggaatca tctgcagcaa taaaaagagc gttaaagcgt atttcctccc 2935861 tttaaaccga aagcgcgaaa acgcataggc cgtaaacgtc acacagagca aagaccctgc 2935921 cattgtaaac aggctgatct tcatagagtt gacataccac tgcacatatt gaaggctttc 2935981 cttgcccgca aataattcct tgtaatgatc gaatgtcgga tgcttcggaa tgatggatgt 2936041 actgattaag ctgttgccgg gattaaagct tgcgcctgcc gtccaaagga gaggataaac 2936101 aatgatgacc gccataaagg ctagcaacaa gtaagagaaa aggagacgga tatatcttct 2936161 gactttcata tctgccagca taccttatgc ctcctcttta aaagactttg tctgtctgaa 2936221 ctgccacaat gcgatggaga taacaaatac agataataaa atggttaaag ccgcagcaag 2936281 tgaatattgg ctggactgca ttgtcaattt ataaatccat gaaacgagga tatctgtccc 2936341 gccggctgtt gatccggtta cagccggacc tccgccattg aatagataga taatattaaa 2936401 gttattaaag ttaaacgtaa actgagtaat gataatcgga gccattgcaa tgaacaccat 2936461 cggaagcgtg atgtatctca gctttgaaaa gacagaagcg ccatcaatcg tagctgcttc 2936521 atacagatcg tccgggatgg attgcaatac gcctgttgag acgagaaaga tgtacggaaa 2936581 tccgagccag ccctgcatga gaatcaatgc aagcctcgac caattggcat ctgtcatcca 2936641 cggaagcgga tctatcccga agaaagccaa gatgtcgtga ttcatcgcac cgaagctatc 2936701 attaaacagt cccgcaaaaa ttaaaatcgt cacaaaaccg ggaacggccc atggcaaaat 2936761 cagaatcgtc cgaaaaaaac gtttaaaccg aaggtctttc tggttaacaa tgatcgcgag 2936821 aaaaatcccc aaggtgactt gcagtgtgga tgcagcaagt gtccaaacca ccgtccaagc 2936881 cagtacatca aaaaaagtcg acctccaaat atcaactgtg aaaatatttg cgaacgtttg 2936941 aaaaccgacc caatcaatta attttgcagg aggagaatga tacaaatcat agtttgtaaa 2937001 cgctaatgca aagctgaata agataggaaa gatcacggcg aaaattaaaa taaacaaaga 2937061 tgggccgctg acgacataag gatagccctc agaaatgata tgctggtatt gttcctttaa 2937121 ggaacttaat ggcttatttt catcacgctg ttttccgctt tggaacgcat cgcgaagatt 2937181 tacataatac accgcaaggc caaagcaggt cacgatgaca gcaataatcc cttccgccag 2937241 cagaaaaacg gaattatccc gcggcacttc tgttcccagt gtaaagattc cccaaaaccc 2937301 catattgagc agatctccaa agaccgcaaa aaacgatgcg cctaagaaaa gaaagacaat 2937361 accttttatc cattgcttgt tataaaattg cccgagtccc ggaatgatag aaagcaacaa 2937421 agcgacttga cgatgctgca ccgttttcac ctctcttaca atacaaatct agctttctct 2937481 ttattttccg ctgtgctttg ccttaatttg tcctttggcc gtttcagctg cttgatccaa 2937541 tgcttgtttc ggatctgcct tccctgttgc aaccgtctgt aatgctgaat cagccggcgt 2937601 ccatatttca ttcatttccg gaatatttgg tgttggctct gagaaacggg attgttcagt 2937661 aacagcccgt gccgcctcgc ttttcataat agccgggtca ttggctaggg atttcacagc 2937721 aggaacttct ttcgtttctt catatcgtgt tttagaattt ttttcatttg ccaggaaaac 2937781 ggctaattct tgcgccagct cttcattctt tgaaaatgca ctgacgttgt agcttttgac 2937841 gccgataaag gagctcatgt ttttcccatt ttccagcttc ggcagtttcg taatgccata 2937901 attgattcct gcattcgaaa aggcttctac attccatgga ccagaaataa ttgcggcggc 2937961 ttttccttct gtgaacagcg attccaacac gttaatccct tgttctccaa taatgccagc 2938021 cgggaacagg ccatctttgt aaaacttctg aatcagcgcc gcacctttga cagctccttc 2938081 attattgatt ccaatgtctg acgggttata gctcccatct ttggcctttc caaaaatgta 2938141 tccgccatat ccgctcatca cactttctgc ataataaatt tgatcgaata gggctaaaaa 2938201 gccaaatttg ctgccgtcag cagtcttttt ggaatagtcg taccactctt ccagcgtttt 2938261 gggcaattcc ttttctgtga tgagatcttt gttgtaaaaa agcacagtcg tttcgaccgc 2938321 ttttggcagt ccataaagct tttgatctac catttgagac tgaatggaag cgtcagtata 2938381 aagtgattga acgtcttttt tgacatgtaa ttccttgagt aatccttccg tgacagcggt 2938441 tccgatttgg tcccctggca ttgttaacac gtcagggcct gtgccggccg gtccatccat 2938501 tcgcaaatct tcaatctgct tggcatacgg tttttcaacg actttgacct tcacatcatg 2938561 ctctttttca aatgcagcca cagcgtcttt aatgccgttg ctcttttctt tatcctccca 2938621 tacaacaagc tctgaccctt ttgaactcga tttggcgctg ctgctttcct ttgggccgca 2938681 agccgccaag gataaactga cagctgcgca gagcatgaat acggaacact tttttgccat 2938741 tttcattgat tgtcaccctt tcggtaggaa tgaaagcgct ttaaagataa tatagcatgc 2938801 ctgagaaaat gtgtaaacaa actatttact tcatagagta aattttttta cctaaataaa 2938861 aaatgactta gtgtcctaag tcatccttaa ttcatactct tcctgacgat taattctgcg 2938921 cccacatata atgtttttac cgttcttctc ttgtcctgca cttgttcaag cagtaattga 2938981 acagcgtttt tacataattc atgtatatca atatgaaacg tcgtcagagg aggcgagaca 2939041 tacttcgcga agctgatgtt gttgatactc acaatgctta ccctgtttgg tatggcaatt 2939101 cctttttcgt tcagggcttg cagacagccc actgcaatcg ggtccgctgc aatcataaaa 2939161 gcagtcggaa gctgatcgcc taatgtgtcg atcgctgctg acatcaggcg gtagccgttt 2939221 tctacagaga atccgcgatg acagaaaata tagcgctcgt ccagcatggc tttttccctc 2939281 atataggatc tgaaggtttg ttcacggatg tccatttcat cctgattggt attcggattt 2939341 ttgtatgtgc cgccgataaa accgatgctc ttatgcccct tctcagtcag gatgtttacc 2939401 gtcttccttg tcatttgtgc caaatcgggc cttaccgagt caaaatgatc gggatcagga 2939461 gttgaatcga tgaacacgcc gttttcagtg agatttctga ggaaagccag ctcttcatct 2939521 gaaaatgtgc cgacggcaat aaacccttcc gtatgttcag gaatgctctc gattccatcc 2939581 gctattttat aagtggtcat atcgacattg aatgctttcg ccagtttctc tacttctaat 2939641 ctcatcgttt taaaatagac atcttctaat tcttctttat ctgtcagcca atataaaaac 2939701 gcaatatgtt tcaccagcgg ccttactgtt tttttgcggt aattgagctt ttccgccgct 2939761 tcatagattt tctcccgtgt ctcatcagga acagaaaggc tttcatcgtt atttaaaacg 2939821 cgggaaacgg ttgagattga aaatcccgct tcctgcgcga tatctttaat tgtcgccatt 2939881 gtatctgcct ccattattca gctcgcattg ttttagtaaa atattttact ttctttttca 2939941 caaatgtcaa gtgcacaaag ccctctggct gccatgtaaa aagactgaac catttgcggc 2940001 tcagtctcag ttgttcgtat cattcggaac cggcggaatt gcccgggaaa tgagttggtt 2940061 attgcacatt ttcctcgaaa tatcccgaaa gcacatcttc cacattcgtc aaatgcgcca 2940121 gcatggcggc ttccgcctgt gcaccgttcc cggcagccac agcattgtaa atccgttcgt 2940181 gctcctcata cagccgctga acggaggtct tcttggaaaa cagccagatt ttcctcgttt 2940241 ccctcattgt ttccagcagc aatgatgaca cgtgattcat caagtgttta agaagttcat 2940301 tttgagaagc gtccgcaagc gcaagatgaa atgcaaagtc tgctttctct cccagctccc 2940361 cgtccgcttc aatgctgccc atttccttta gtgcatcctg aattctttcg agatctgctt 2940421 ctgtcctttt ttcagccgct agtgaagcca cgccgatttc aagcagtttt ctgacctcga 2940481 gcagctgctt gacgtcctct tttttcatca gaagggcggc tgagagcggc tgagaaattt 2940541 gattgagctc aaattccttc agatacgtgc cttctccctg tttcatttcg acaagcccca 2940601 tcgcttttag cgcagaaagt gcttcgcgaa ccgctgaacg gctgacttga aagctctcag 2940661 caagcgcctg aacagagtcc agtttatccc ccggcttcaa ttcgccattt ttgatcatat 2940721 ctaatagggc atccgctact tcttcatata tttttttgtt ttaatctgtt tatatttcaa 2940781 tgcaattcac cccgtaactt gtaggtctgg ctgtttacga tctattatac tctgttttgt 2940841 gggccgccaa aagattttga ctattttgtc aaaaagtctt gtactttgat ttttttcaaa 2940901 atataatgct aggtaactgg tcttattacc cagtcatcag atgatcatat catctataga 2940961 aaccgcttac atatggcgcc agtttatgtt tcaaggaggg gtttgggatg caatggacac 2941021 aggcatatac gcctataggg ggaaatttgc tattatcagc gcttgccgca cttgtaccga 2941081 ttattttctt tttttgggca ctcgcgatta aacggatgaa ggggtataca gcaggcttgg 2941141 ccacattggg gatcgccctt atcattgctg tattggttta tcgtatgccg gcggaaaaag 2941201 cgctgatgtc cgcgacacaa ggagccgtat acggattgtt gccgatcggc tggatcattg 2941261 tgacgtctgt ttttttgtat aaaatcactg tgaaaacggg acagtttgat atcattcgca 2941321 gctctgttct ctcgattact gatgaccgac ggcttcaagc tctcttgatc gctttttcat 2941381 tcggggcttt tttagaaggg gcagcaggct tcggagcgcc ggtcgccatt tctgccgcgc 2941441 tgctggtcgg tctcggcttt aatcctcttt atgctgcggg gatctgtttg atcgccaata 2941501 cggcgccggt tgcctttggg gcaattggga ttccaattac agccgtagaa gggccgacag 2941561 ggattccggc gatggagatt tcgcaaatgg ttgggcggca gctgccgttt ttatccgtat 2941621 ttattcctct ttatttaatc atcatcatga gcgggttcag gaaagccttg gagatctggc 2941681 cggcgattct cgtatccggt gtttcctttg ctgttgttca atatctcagt tccaattttt 2941741 tagggcctga gctgcccgat gttttgtcag ctcttgtttc aatggctgcg cttgctgtgt 2941801 ttttgaaatg gtggaagccg aaaacaacat tccggtttgc cggtgaacaa gagtcggccg 2941861 cctcaattga aacggcgcgc acaaatccgg cggcgcctgc atacagaggc ggacagattt 2941921 ttaaggcttg gtcgccattt ctgctgctga cggcgatgat ttccgtatgg ggcattccat 2941981 ctgtcaaatc cgcgctgacc gggcattatg aaggctctgc ggtgttcttg aagtggctga 2942041 atgctgttgg agaaaaactg actttttccc ccggtgtgcc ttttttgaac aatcagattg 2942101 tcaatgctga cggtacgccg attgaagcgg tttacaagtt ggaggtgctt ggttcggccg 2942161 gcaccgcgat attgattgcc gcagtgctgt caaaattcat cacggcgatt tcgtggaaag 2942221 actggggaac cgtttttaaa gaaacagtcc aggaattgaa gcttccgatt ttgaccattg 2942281 cttctgtcgt tggttttgcc tatgtcacca actcctcggg aatgagcacg acactcggga 2942341 tgacactcgc gctgacaggt tcgatgttta ccttcttttc gcccgttctc ggctggctcg 2942401 gcgtcttcat taccggctcg gatacttctg ccaacctgct gttcggcaac ctgcagaaag 2942461 tcaccgcatt atcagtcggc atggaccccg ttctgtctgt ggccgccaac tcttcaggcg 2942521 gtgtcacagg aaaaatgatt tcaccgcagt cgatagcggt ggcgtgcgcc gcggtaggac 2942581 tcgccggaaa ggagtcagat cttttccgct ttaccattaa acacagtctg tttttgctgc 2942641 tgctcgtctg tatcatcacc tttttgcagc atcacgtatt cagctggatg attccttaaa 2942701 aaaatcctcc cgtctaggga ggattttatt tatatcgctt tctcgctgcc gatgacggaa 2942761 tattcatttg atcgcgatat tttgccacgg tgcgtctcga gatttggatg ccgtgttgtt 2942821 catacagcaa atcgacaagc ttttggtctg aaagcggttt tgttttgtcc tcttgattga 2942881 tcaggttttc cagatgcgtt ttgactgcat aattcgacgc atctccatca cctgaagcct 2942941 cggcttttgc tgagaaaaag agtttcatct caaacagccc gtaaggcgtt tgtattgttt 2943001 tccctttaat ggcccggctc acagttgatt catgaaggct tagacagtct gccacctctc 2943061 tgagagtcag cggcttcatt gcgcttcgcc ctttcagaaa gaaatccttt tggcgtgtga 2943121 tcagttcatt gataattctc gtgattgtct gttttcgctg ccgcagcgcg cggctcagcc 2943181 agcgccactc ctgatatttc gcagataaat aggagacagt atcctgacag gagccggatg 2943241 ataaaagcgt tctgtactgc ggatgcagat cgatctcggg aaacgagcgg gtattcagtt 2943301 ccgctgcgat gtgcccattt tttacggtga taaaaatgtc aggctcaata tacacatctt 2943361 gctctggccg ggcaaacaga aggccaggtc taggatgaag agccgcgata tcatctgaga 2943421 tatcttgaat ggtatgaagc ggaattcccg tctctactga aagcgttttc catttttttt 2943481 gcgcaaaagc atcaaaatga gctgaaacca gcatttccgc ttgttcattt ctgttcggca 2943541 gccgctgtaa ttgaagaagg atgcattcct gcaaagatct cgcgccgatt ccagccggtt 2943601 ctaacgactg gagttttgcc aaaacagcct ccgcttcctt ggccgataca gataatcgcc 2943661 gtgctgcctc ctctatatct tcttccaagt acccgtttga atcaagcgaa tgaatcagat 2943721 aattaaaaat ctttttttca gtgtttgtca gattcatatc gagtgactgc tgttttaacg 2943781 catcctgcaa tgttttttgc ggattactta attgaaggcc cgcttcctgt gcattcatcc 2943841 tgtttttgtt tgttttatgg taagatagtg gcggtgtgtc tgtttccttt cgttcaataa 2943901 gagggttttc cagtgagagc tcatcaatgt actcggcgag ttctgccgaa tgatagccaa 2943961 gcagcgtgat ggcctgcctg agctcctgtg tcagttgagg ctttaatact tgtacttgct 2944021 gaagtttcat atccatcttg ctcactcccc tttcttcatt gtacatgatt gagatcacac 2944081 cgtatacatt tatgaaaaag gagctgccaa agaaatgtct gaactttttt ccgtccctta 2944141 ttttattgag aatttaaaac agcatattga aatgaatcag tctgaggata aaatccacgc 2944201 gatgaacagc tactaccgtt ccgtcgtctc aacactagtg caggaccagc tgacgaaaaa 2944261 cgcagttgtc ctgaaacgga ttcagcattt agatgaagca tacaacaaag tcaaacgtgg 2944321 agaatcaaaa taaaccttcc gaattcggga agatgatgat cggttaaagg gctaacgttc 2944381 gcatctatag gggaaatctg tttataatgg gggaaaaagg gagagaacac aatgactcat 2944441 caaatagtaa cgactcaata cggcaaagta aaaggcacaa cggaaaacgg cgtacataag 2944501 tggaaaggca tcccctatgc caagccgcct gtcggacaat ggcgttttaa agcacctgag 2944561 ccgcctgaag tgtgggaaga tgtgcttgat gccacagcgt acggctctat ttgcccgcag 2944621 ccgtctgatt tgctgtcact ttcgtatact gagctgcccc gccagtccga ggattgcttg 2944681 tatgtcaatg tatttgcgcc tgacacccca agtaaaaatc ttcctgtcat ggtgtggatt 2944741 cacggaggcg ctttttatct aggagcgggc agtgagccat tgtatgacgg atcaaaactt 2944801 gcggcacagg gagaagtcat tgtcgttaca ttgaactatc ggctggggcc gtttggcttt 2944861 ttgcacttgt cttcatttaa tgaggcgtat tctgataacc ttgggctttt agaccaagcc 2944921 gccgcgctga aatgggtgcg agagaatatt tcagcgtttg gcggtgatcc cgataacgta 2944981 acagtatttg gagaatccgc cggcgggatg agcattgccg cgctgcttgc tatgcctgcg 2945041 gcaaaaggcc tgttccagaa agcaatcatg gaaagcggcg cttctcgaac gatgacgaaa 2945101 gaacaagcgg cgagcacctc ggcagccttt ttacaggtcc ttgggattaa cgagggccaa 2945161 ctggataaat tgcatacggt ttctgcggaa gatttgctaa aagcggctga tcagcttcgg 2945221 attgcagaaa aagaaaatat ctttcagctg ttcttccagc ccgcccttga tccgaaaacg 2945281 ctgcctgaag aaccagaaaa agcgatcgca gaaggggctg cttccggtat tccgctatta 2945341 attggaacaa cccgtgatga aggatattta tttttcaccc cggattcaga cgttcattct 2945401 caggaaacgc ttgatgcagc gctcgagtat ttactaggga agccgctggc agagaaagtt 2945461 gccgatttgt atccgcgttc tctggaaagc caaattcata tgatgactga tttattattt 2945521 tggcgccctg ccgtcgccta tgcatccgca cagtctcatt acgcccctgt ctggatgtac 2945581 aggttcgatt ggcacccgaa gaagccgccg tacaataaag cgtttcacgc attagagctt 2945641 ccttttgtct ttggaaatct ggacggattg gaacgaatgg caaaagcgga gattacggat 2945701 gaggtgaaac agctttctca cacgatacaa tcagcgtgga tcacgttcgc caaaacagga 2945761 aacccaagca ccgaagctgt gaattggcct gcgtatcatg aagaaacgag agagacgctg 2945821 attttagact cagagattac gatcgaaaac gatcccgaat ctgaaaaaag gcagaagcta 2945881 ttcccttcaa aaggagaata aatatgggga aaacaggata cattggtgct gccattgttg 2945941 tggcagcttg tatcattatt ttgtcggccg tggtatgttt acgggacaca gtctattacc 2946001 agcctatgcg ctggactggc atcatactgt ttttcgcggg aattgtgatg gttcccgcat 2946061 actcagcaaa aagaaaaccc ggaaaagaga agtaattctc ttttccgggt ttttatgttt 2946121 attataatct tcccgcgcga atatcgtctg tcattccctc ataaggagcc ttcgaaatca 2946181 cttcttcgtt gtcgactcct tcatttttca gaaatgtaat ttccgcaaat tcaggtacaa 2946241 cgtattttgg atacgtttca tatttttcgc gggattcttt catcaaatca atgtggtcat 2946301 tttggtagca aaccgtaatt tcaggatgtt catgcaccca tttcgggaag aaaataatgc 2946361 catgcatgcg tttttcattt ggcataaagt ttaatgaaac atccgtgcca gtcggctctg 2946421 tccaagacac tttatatacg ccttctgtca gtttgacaat attcacttcc tgatctcgaa 2946481 cccagcgtcc ggcaaccatt ccgctatgaa ttctataatc aattgtatgg tcgtttttaa 2946541 tataaatctc gtattcccat ccgttttcat acgtataaat catgtggctt ccgataaagt 2946601 tttccatctt acacactctc cttagtcttt tactgtactt cataaatgtc tagtagaacg 2946661 taatcagggg ttctttctgc ggaaccgata aacaagcggt catggagcca ttgatagact 2946721 tcactgcctg tttcaaacgt cggtaccgta cgaaaataaa catgctccgg ttcaataatt 2946781 tccccggctg ccgcttgttt tcgaaacggc ttgctgactt gccgtattcc attgttttca 2946841 atgtaaatca gttcatgatc tgctgtttca atcacatacc tggcagataa atctgttctg 2946901 ccgttagcgc gaatcatttg tgaatcggca ccgcccggca aaatacgtcc ctttacttcc 2946961 ccggttattg ttcccgaacg aatcggaatg aatcatctca gtcccaggct tgtctcacca 2947021 atcgtgatag gcggatcaac cttgatttct aaagaggcga atggttttaa aaccggcttc 2947081 ttcacgagaa ccacctcacc ttcagaaaaa atcatgtaac tatttacatg ttcactttaa 2947141 caccattgca gttaactgtc aaacaatagg aacataaaaa aacaaggact gtttgaagac 2947201 agtccttgtc tgaagctagc tttgataagc aagatatgtg ctgacagtgc ttttggcaag 2947261 acaggcagag gaatctataa tcggaatctc actttgaata tgatctaaca ccgcatttaa 2947321 atccgtgcag gctgaaatga tgatgtctgc atgctgactg atttcttcat atagcgtctg 2947381 ccacaatgct tgtgtatgct gcatatgatt tggctgtttg attgcggcga taagctggtt 2947441 cacagcctgc tgccaatggt ccttgtgaat aacttcttgt ccatttccct tcagaacttt 2947501 ttggtagatg gcggattgga tggttggctc tgttcctaaa accaccgctt tttttgcggg 2947561 atgcggaatc tcttttatcg tttcctcaac aatatgcaac ataggaactg acaatgcctg 2947621 ctgaatctct tcatagtaga catgcgccgt attacaaggc agcgcaatga aatccacgcc 2947681 tgttttctcg agctttaccg ctccgtcgat aatcgctttt ttcatctcgt catggtcaat 2947741 tggacgatct gcatagaagg gcgtcgggca tgaatagatc atcatgtgcg gatagtcaat 2947801 atcgtttgaa gccccataca gcttctgaca gtaatcaatc accttatcaa taaacggcga 2947861 ggtcgatttc ggccccattc cggctaatat tccgatcatc aaattcattc ctttctactt 2947921 cgtacggacc gcttcttcct ctgagccatc ctcatagagg ataaagcttt tcgcagcatc 2947981 ctcacctaat gtaaactcga cttcaacaga caatgctcgc agaaagaaac gggtttccga 2948041 ggaaggaaat aactccagtc tcagctgtcc ggcgatctcc aaataaagcc gttcattctc 2948101 ggttgtcacc tgtgcagccg tcccatcctg caacaggtag ctgccaacat agcggctgta 2948161 tatcgccgta tcaattgctt ttttcttttt atcagcagga cgttccggga catcatatgg 2948221 ctggccaaat agaatatgtt ccgccgcctt cagaatcgct tgttcatatt cagtatcctc 2948281 ttccttatta ctcaaataga tcagcgtttt acgatgatcg atatatcgga tcatcatcgt 2948341 cgaatagccg ggccatcctc cgctgtggct gacaatccgc cctttttcag gactgttttg 2948401 cagcacccag ccaaagccat aatcaattgt ttctccattg ttgaggcgca ctggagaaaa 2948461 cgcagattcc ttagaagcct tgctgatgaa atcgtcctga tataaagcct gatcaaatcg 2948521 aaacaaatcg cttgtgacag agttaaccgt cccatctccc tgtatgccat cgagatacac 2948581 aacatagttc gtttcctcca gctcatcagg gaggacgtat gtttcggaat gtacatcata 2948641 cacatatcca tatgcataat gatcaattcg ctcaggcgaa agcctcctgt tatacactct 2948701 tgtttcattc atgcctgccg gtaaaaaaat acttgttttt ataaaatccg catagctcat 2948761 gccagatgct ttttcaatga taaccgccag cagcacatac cccgtattgc tgtacatcca 2948821 gccttcattc ggttcaaaat aaccagatag cccctcattc atcagcatat cgacaatatc 2948881 ctgattcacc gcaatcttgt gtgaatccca attggcaaaa aaccatccca tataatcagg 2948941 aagccctgac gtatggttca ataaatgccg aatcgttacg ccctgatacg gaaaaccggg 2949001 cagccagcga tccactttat cctcatagcc aagaatcccc ttctcctcca gcaagatgat 2949061 tcccaatgct gtaaaaggct ttgacaaaga cgctaactca aacaaagagt tggttttcaa 2949121 cgggcgtttt tccgtcattt ccgcatagcc aaaagagtgg tgatataaaa tatcgccacc 2949181 ctccgcagcc agaaccgtcc cgttaaactg atgtttttcg cctaatgtct caaataacgt 2949241 ctgaagatgc tttcttttat tctgcttcat tcctccacct cccatatctc tgtacgttac 2949301 taacctacta acgtttcaaa tattttgaaa aatccttcag ttagagatcc tttttaaccc 2949361 atcacatata cctgccgttc actattattt agtgaaatga gatattatga tattttctga 2949421 attgtgatta aaaaggcaac tttatgccca tgcaacagaa actataaaaa atacagagaa 2949481 tgaaaagaaa cagatagatt ttttagttct ttaggcccgt agtctgcaaa tccttttatg 2949541 attttctatc aaacaaaaga ggaaaataga ccagttgcaa tccaaacgag agtctaatag 2949601 aatgaggtcg aaaagtaaat cgcgcgggtt tgttactgat aaagcaggca agacctaaaa 2949661 tgtgtaaagg gcaaagtgta tactttggcg tcacccctta catattttag gtcttttttt 2949721 attgtgcgta actaacttgc catcttcaaa caggagggct ggaagaagca gaccgctaac 2949781 acagtacata aaaaaggaga catgaacgat gaacatcaaa aagtttgcaa aacaagcaac 2949841 agtattaacc tttactaccg cactgctggc aggaggcgca actcaagcgt ttgcgaaaga 2949901 aacgaaccaa aagccatata aggaaacata cggcatttcc catattacac gccatgatat 2949961 gctgcaaatc cctgaacagc aaaaaaatga aaaatatcaa gttcctgaat tcgattcgtc 2950021 cacaattaaa aatatctctt ctgcaaaagg cctggacgtt tgggacagct ggccattaca 2950081 aaacgctgac ggcactgtcg caaactatca cggctaccac atcgtctttg cattagccgg 2950141 agatcctaaa aatgcggatg acacatcgat ttacatgttc tatcaaaaag tcggcgaaac 2950201 ttctattgac agctggaaaa acgctggccg cgtctttaaa gacagcgaca aattcgatgc 2950261 aaatgattct atcctaaaag accaaacaca agaatggtca ggttcagcca catttacatc 2950321 tgacggaaaa atccgtttat tctacactga tttctccggt aaacattacg gcaaacaaac 2950381 actgacaact gcacaagtta acgtatcagc atcagacagc tctttgaaca tcaacggtgt 2950441 agaggattat aaatcaatct ttgacggtga cggaaaaacg tatcaaaatg tacagcagtt 2950501 catcgatgaa ggcaactaca gctcaggcga caaccatacg ctgagagatc ctcactacgt 2950561 agaagataaa ggccacaaat acttagtatt tgaagcaaac actggaactg aagatggcta 2950621 ccaaggcgaa gaatctttat ttaacaaagc atactatggc aaaagcacat cattcttccg 2950681 tcaagaaagt caaaaacttc tgcaaagcga taaaaaacgc acggctgagt tagcaaacgg 2950741 cgctctcggt atgattgagc taaacgatga ttacacactg aaaaaagtga tgaaaccgct 2950801 gattgcatct aacacagtaa cagatgaaat tgaacgcgcg aacgtcttta aaatgaacgg 2950861 caaatggtac ctgttcactg actcccgcgg atcaaaaatg acgattgacg gcattacgtc 2950921 taacgatatt tacatgcttg gttatgtttc taattcttta actggcccat acaagccgct 2950981 gaacaaaact ggccttgtgt taaaaatgga tcttgatcct aacgatgtaa cctttactta 2951041 ctcacacttc gctgtacctc aagcgaaagg aaacaatgtc gtgattacaa gctatatgac 2951101 aaacagagga ttctacgcag acaaacaatc aacgtttgcg ccaagcttcc tgctgaacat 2951161 caaaggcaag aaaacatctg ttgtcaaaga cagcatcctt gaacaaggac aattaacagt 2951221 taacaaataa aaacgcaaaa gaaaatgccg atatcctatt ggcattttct tttatttctt 2951281 atcaacataa aggtgaatcc catatgaact atataaaagc aggcaaatgg ctaaccgtat 2951341 tcctaacctt tttaggaata ttgctgttta tcgacttatt tccaaaagaa gaacatgacc 2951401 aaaaaacaaa atcaaaacag aagccggact accgggcggc atatcatttt acgacgccgg 2951461 ataaatggaa aaatgaccct caaaaaccga tctattttga tggcaagtat cattatttct 2951521 atctatataa ccgggattac ccaaaaggca acggcacaga atggcgccat gccgtctcag 2951581 aggatttggt gcactggacc gatgaaggcg tggcgattcc gaaatataca aacccggacg 2951641 gtgatatttg gaccggttcc gtcgtggtgg ataaagagaa cacagccggc ttcgggaaaa 2951701 atgcgcttgt cgcgattgtg acacagccct cagccaaaga caaaaaacag gaacaatatt 2951761 tgtggtacag cacagataag ggaaaatcat tcaaattcta cagtggcaac cccgttatgc 2951821 ctaatccggg cacagacgat ttcagagatc cgaaagtcat atgggatgac caagataaca 2951881 aatgggtcat ggtcatggct gaaggatcaa aaatcggctt ttatgaatcc gataatctta 2951941 aggactggca ttacacaagc ggattcttcc cagaacaggc gggaatggtg gaatgtcccg 2952001 acctctacat gatgcgggca agcgacggaa cgaataagtg ggttctcggt gccagcgcga 2952061 atggcaaacc gtggggcaaa ccaaatacgt acgcctactg gaccggaagc ttcgacggaa 2952121 aagaattcaa agcggatcag actgaagccc aatggcttga ctatggcttc gactggtatg 2952181 gcggtgtgac gttcgaagac agcaaaagca cagatccatt agaaaagcgg tatgcgcttg 2952241 cctggatgaa caattgggat tatgccaaca acaccccgac aatgaagaac ggctttaacg 2952301 gcacagattc tgtcatacgc gaactccggc tgaaggagca ggatggaaca tacagcctcg 2952361 tctcacagcc gattgaagct ttggagcagc tgactgtttc aactgacgaa atagaggatc 2952421 aggatgtgaa cggatcaaaa acattgtcga taacaggtga tacgtaccag cttgatacgg 2952481 atctttcttg gtcagagcta aagaatgcag gcgtcaggct cagagaatca gaagaccaaa 2952541 aacgccatat tgatgtcggc attttcgctg aaggcggcta tgcttatgtc aatagagcag 2952601 ccacaaatca gcctgacaaa agcaatacct atgtcgaaag caaagctcct tatgatgtaa 2952661 acaaacgtaa ggtgcatttg aaaatacttg tcgataaaac aacgatagaa gtatttgttg 2952721 gcgacgggaa aaccgttttt tcaaatgaag tcttcccaaa gcctgaagat aaaggaatta 2952781 ccctttattc tgacggcggc acagcctcct tcaaaaatat aacagtgaaa cactttgatt 2952841 cgattcatga ataaaaacag gggcggcgca ggctgcccct gtttttttat taggagcggt 2952901 attctctgtt acatattggg cattgtaagg aatataaggc tggtttcaaa ggaggaagcg 2952961 aatgtctaaa caaggaaatt ttcaaaaatc aatgtcgctg tttgatctga ttttgattgg 2953021 gatgggagcc atctttggat cagcgtggct gttcgctgtc agtaatgtcg cttcaaaagc 2953081 agggccctcc ggcgcttttt cctggatcct cggaggagcc attattttgt taatcgggct 2953141 tgtatatgcg gagctcggag ccgctctgcc ccgtaccgga ggcatcattc gataccccgt 2953201 ttattcacat ggccaccttg tcggctactt aatttcgttt gtcacgattg tcgcttatac 2953261 aagcttgatt tcaattgaag tgacagctgt gcgccagtat gtggcctatt ggtttcccgg 2953321 cctgaccatt aaagggtctg attcgcctac catttccggc tggatcttgc agtttgccct 2953381 attatgcttg tttttcctgc tgaattattg gagcgtcaaa accttcgcta aggcgaattt 2953441 catcatatcg atttttaaat atattgtgcc gattaccatc attattgtgc tgatctttca 2953501 ttttcagccg gagaatttat ccgttcaagg atttgcaccg tttggattta caggtattca 2953561 ggctgccatc tcgacaggcg gcgtcatgtt tgcgtatctc ggcctgcatc cgattgtatc 2953621 tgtagcaggt gaagtccaaa atccaaaacg caatatcccg atcgctttaa tcatttgcat 2953681 catcgtttca accatcattt atactgtttt gcaggtcacc tttattggtg caatcccgac 2953741 agaaacactg aaacatggct ggccggcaat tggccgggag ttctcattgc cgtttaagga 2953801 tattgcggtc atgctcgggt taggctggct tgcaacgctt gtcattttag acgccattct 2953861 gtctcccgga ggaaacggga atatctttat gaatacgaca tcccgccttg tttacgcctg 2953921 ggcgcgtaac ggcacattat ttggcatatt ctcaaaggtc aataaagata cggggacacc 2953981 ccgcgcttcg ctttggcttt cgtttgccct gtccattttc tggacacttc cctttccttc 2954041 gtggaacgcg ctcgtcaatg tctgttcagt cgcgctcatt ctttcatatg cgattgcacc 2954101 catttcttca gctgcgctga gggtcaacgc gaaggactta aacaggccgt tttatttaaa 2954161 gggaatgagc attatcgggc cgctttcctt tatatttaca gcgtttatcg tgtactggtc 2954221 aggatggaaa acagtctcct ggctgctcgg ttcacaactc gtgatgtttt tgatctatct 2954281 ctgtttcagc aaatatacgc ctaaagaaga tgtcagcctt gctcagcagc tgaaatcagc 2954341 ctggtggctt atcgggtttt atattatgat gctgatcttt tcctacatcg gttctttcgg 2954401 acatggttta gggattatca gcaatcccgt cgacctcatt ttagtcgcga tcggctcact 2954461 tgcgatttat tactgggcaa agtataccgg gctcccaaaa gccgccattg attatgataa 2954521 ataaagaagc aagaggtttt cttgcttctt tattctttac aaacaaacat acacgcgata 2954581 aaatgaatga gagtcagtca ttactggagg tgttcctcat gccaaaacaa acatcgggta 2954641 aatacgaaaa aatattgcag gcggccatag aagtcatttc tgaaaaaggc ctcgacaaag 2954701 cttctatttc tgatattgtc aaaaaggccg gcactgccca aggaacattc tatttgtatt 2954761 tttcatctaa aaatgccctc ataccggcca ttgcagaaaa tctcctcacc catacacttg 2954821 atcaaatcaa aggtaggctc catggggacg aggatttttg gaccgtttta gatatattaa 2954881 ttgatgagac atttctcatt acagaacgcc ataaggatat tattgtcctc tgttattccg 2954941 ggcttgcgat cgaccactcc atggaaaaat gggagacgat ctatcagcct tattattcct 2955001 ggcttgaaaa aatcatcaac aaggccattg caaaccatga ggtaacggaa ggaatcaatt 2955061 caaaatggac ggccagaacg attatcaact tggtcgagaa tactgcggaa cgattctata 2955121 tcggatttga acaagatgaa aatgttgaag tgtataaaaa ggaaattttc actttcttaa 2955181 aacggagctt aggtactgct taaaaaatga ctgggtaaca ccgctcattt tttaatgccc 2955241 taaaaatgac tgacgttcat tcataaaata gagaggtgtt tcatttgaat tgggttcttg 2955301 tttttattgc agggctttta gaggttgttt gggcctcttc cctcaaacat gccgattcgc 2955361 ttttggattg gatcatcatt tttatcttaa tcgcggtcag ctttatcctg ttgatccgct 2955421 cttatcaaaa aatcccgatg gccgcggcgt acactgtgtt tgtgggaatc ggaaccgtcg 2955481 gaacatatct gactggaatt gttctgggcg aatccttctc agcagcccaa atgttctttt 2955541 tagctttatt gctggctggc attttaggaa tgaaattatt tacgaaagaa agcaaatctc 2955601 agccgggagg tgaaaaataa tggcatggtt tttattagtg attgccggca tagaagaaat 2955661 tatagctgcc attgccatga aatatataga cggaacaaga aaaaaatggc cgatcattgt 2955721 gatgactgtt ggattcggct tatcctttta ctgcctgtcc caagcgatga tcgtcctgcc 2955781 tgccggagtc gcatatgccg tctggactgg cattggaagc attggtgttt cggcggtcgg 2955841 gctcatctgg tttaaggagc ggtttcagct ttcacaggtg atttcacttt gccttatcct 2955901 agccggcgtc atcggcctgc gtcttacgtc atcttcataa aatcaaggca tatacagctg 2955961 tatatgcctt tgccattaag cttcgtgatg tttttgaaga tgaagcggcg gcgggatgag 2956021 ccagcctttg ttttttagca gccttaagta ttttgcgccg gttgccgctt tcgacatatg 2956081 aaattgccca aacatcatgg caatatcctc acgaatcgat tgccccatca ttttgctgca 2956141 tgtcacaaga cctgcagcat tttctgctgc cgcggaagcc gccacatccg gatcgagaaa 2956201 ccgtgcacca ggcggaatat cgttaagatc tgctgtcggc ggttcaggag aagccggcgg 2956261 cagcgccacc ccgttttctt tcaggatcgt gctgacctgt ttgatttcat cttggcattt 2956321 ctcaatagac tcacgaagca gcttcttcag gtcgtcatca ccgacatgat tcaatagcat 2956381 ttggtaattg ccgaccattt tattgcccgc catcacataa ctccacaagc cgaatacctc 2956441 accgtaatgc atcggttcat cctgcggatt tccgcttaaa atacccatgc tcattctcct 2956501 cccatattca atattgcaca tttcataacg tgcccaagcg gaggaacatt tatgtttcag 2956561 cggaaaagat ttatgaaatg aaacaaaaca aaaaagacaa gagtggcaag ttgccaaacc 2956621 attgtctttc ctgttgtttg attggacgca ctgaagggat tcgcaccccg acagacaaga 2956681 taccggaaac cattcaagtg ctttttagta tgagtcattg attctgtctt taataaactt 2956741 taacgagatg gcgggatgct ttgcggaaaa cgaaatacat tttcggggtc atatttcgcc 2956801 tttatttctc gaagccgcgc aaagtttgcg ccataatatt cttttccgaa gttttcaatg 2956861 ttttgatctg gaacattaac atatgaacct gctacatatg gttgcatcag ctgacgcact 2956921 ctttcaactg atgcaagatt tgaatcttct tgtgatttat ttttccaact agccgtccat 2956981 tccgtataaa ataatggatg gcgccaaaaa aaggcagttt cgtctttagg gactctgctt 2957041 atagcaccac cccaattgat aaaaaagaaa ttggcttctg ttccagtagc atcttccaaa 2957101 aattttctca tgattgaaat gggttcgtca gaccaaaaat catgacccca tgccgaggag 2957161 aatttaacac tctgatcatt tctgccaggg atgggttcgt cagggtctaa gaaatctata 2957221 gcatctggat agtataatgt tttgatatct gcttctgttg gagttcccgc atgtaataaa 2957281 ggttttaata atcgaatcaa ttcagttttc gaaccgagga aaattccttc tgcatgacac 2957341 aaaccattta ttttgctgta aatttcaagg tagcatccta atcgttcatc tacaaacgga 2957401 gcccatttct gccaagcttt aaataccgtt tctaattgtt cccacggcca gataatattg 2957461 aagacggttg cagttttagg ggcacgatga actttgaatg tatattgggt attatatcca 2957521 aagttacctc ctcctccgcc tctagaagcc catagcaaat cctcattgtg agattgatct 2957581 gcgtgaataa tccttccttt tgcatctacc gttttcagcg cgagaaggtt atcacttata 2957641 aggccaatcg atcgtgagag tacaccaaat ccgccgccca tcgtaattcc cccgattcca 2957701 actgttgggc tatctccaaa cggagccata aaaccgtctc gagctaatcc ctttacaagc 2957761 gggccaacgg gaataccagt ttgaacggtt gcaatagcgt tttcttcatc taagaaaact 2957821 ttattcatgt cactcacatc aataacaatt cctccactta ctactgaaag gttcttatct 2957881 aaagcatggc gaccgcttct gacacgtaag ggcactttat tctcacgagc ccatttaatg 2957941 gcattactta catcgtatga attttgcgca aaaacaaaga caagaggata gacatccaca 2958001 taagggttcc aattcttaat agcctctgta tagccggggt ctcctttgaa gattacacgc 2958061 cctgtcaact gtgttgatcc catatattat ttcactccca aagaaattcg attcagatac 2958121 taaaatatgc aggagctgga taatcgcata gacaaatgat ctacgaacta taaatataat 2958181 acgctaaggc ctttttcgtc ggtgaggtct gctgagaaac atttttcaaa caattttgag 2958241 caaacttcct gtccaatcct ccaacaagcg ttttttctta tcgtttttag gagcagtgtc 2958301 cagttttttt cggagtgaat attcgtttag gccaaaagaa aagagagatg aagaagtgtt 2958361 tagtaccaga ggtatacatc catacaacag actctagatc atcatatact gaatgtatgt 2958421 agaaaggaga catcagcttt ggcaaaatat cggattatga cctttgacgg cggcggtacc 2958481 ttaggtgctt taagtttaca actattaaac agattggcta ggcaaaaccc gaagttaatt 2958541 agtcgaaccc atgtattttc gggaaattca atcggttcat ttactgccct tgcattagca 2958601 agcggaagat ctccgaggga aacacttcag tattttgagg atgaaatcct acccgcattc 2958661 agcatttccc ggccaggcgg acctgttttc aaccaacaat taccctattc cggttttatt 2958721 aaagcggtaa gaaatttttt cccagcagat cttcaactta tagatttaag aaaacgaatt 2958781 gttgtcccat cattcaaatt atactctcaa aaactggacc gttggactcc tgtcttattt 2958841 cacaattttc ccggctctcc ctatttaaat gaaaaagtga gtgatgtcat actgcggagc 2958901 agcggtgctc ccgcgacgca acgcgcctat caaaactatg tggacggata tgtagtagca 2958961 acgaatccca gtacagccag tatcgcgttt gcagttggta aagccaacgt gccattggat 2959021 caaattgcgg tattgtccat cggaacaggt gaagccccga ctcggttaag aagagatacg 2959081 aggggatggg gaatggtaag tgcagataac atacgtcccg aaaatctgaa gaaccttcct 2959141 ccaaattggg gagtcctttt ggacaggtcg cctaatgaac ctttactgcc atttcttcag 2959201 atgattgctg gcggtaatgg gtactatgaa tccatggtca gtgcgaatct tctgggagat 2959261 cgttttttcc ggttagatcc gcggattccg aacttctcca aaacggaccc tgccgtcgtt 2959321 cccgctgtca ttgaaattgc gaacaaaaca aacttacagc ctgcgaatca atttatagag 2959381 aagaactggg ggagcaaata attatttatt ttaaatcaat tctcgcttat acaattttgt 2959441 ccgagagaag attctcaaaa taaatacagg caatgggtag aaccggattt ttttaaaggt 2959501 ttgttaatca caagctaata agatgaatga aaaaatcaat tcatacttct tcttttgaaa 2959561 gtgagggttc aaactaaaga atgtaattga aatgttactc taaggtatgc aattcccttt 2959621 ttcacacaaa aaaagacaag agcggcaaat cgccaaaccc ttgtctttcc tgttgttcta 2959681 ttggacgcgc tcggagggat tcgaaccccc gacagacgtg gtaccggaaa ccaccgctct 2959741 atccaactga gctacgagcg catatagact gcgttatgag aacgtcagca caactaatta 2959801 tacgataatt cctttcaaat aacaaccctc tatttcgaga ggccgttttt taaatagaca 2959861 aagcatctta attggcaatc tgacatacga tggtttgaac ccctgtattt ttggggaaaa 2959921 tgggaaaaag agacgacttt gcatatcagg ccagcttttt gtttgacctt tattgaccaa 2959981 aaatgtatca tgtaactaca tacttaccta aaaggtgaag gaggagcatt atgaatttaa 2960041 tacctacagt cattgaacaa acgaaccgcg gggaaagagc gtatgacatt tattctcgtc 2960101 tattaaagga tcgtatcatc atgcttggat ctgcgattga tgacaacgtt gcgaactcca 2960161 tcgtgtcaca gcttttattc ttagcagcag aagaccctga aaaagaaatt tctctttaca 2960221 tcaacagccc gggcggctct attacagccg gtatggcgat ctatgatacc atgcagttta 2960281 ttaagccgaa ggtatctaca atttgtatcg gtatggctgc gtcaatgggc gcgttcctgc 2960341 ttgcagccgg cgaaaaaggc aaacgctatg cgcttccaaa cagtgaagtc atgattcacc 2960401 agcctcttgg cggtgcgcaa ggtcaagcga cagaaattga aattgctgcg aaacgcattc 2960461 tcttgcttcg cgacaaatta aacaaagtcc tagctgaacg tactggccag ccgcttgaag 2960521 tgatcgaacg cgacacagac cgtgataact tcaagtctgc tgaagaagcg cttgaatacg 2960581 gcctgattga caaaattttg actcacacag aagacaaaaa gtaataacac aacctgcaag 2960641 agctgcgtct cttgcaggtt tttttcattt caaggaattg actcccttat tctatactgc 2960701 tcccattcct catgtaacag ctcaagcgtc aaatcactcg tctgcctcac aaccagatca 2960761 gcaccaagca tcggctgtcc ttgaccgaca ccaaccgcaa acatccccgc agatttgatt 2960821 gcagaaatgc ctgcttctgc gtcttctatt gccgcgcaat cagcagggga aacatcgagc 2960881 atcgctgcag ctgttaaaaa gatgtcagga tcaggcttcc ccttcgcaag agtcgtcgga 2960941 tcaacaatgg catgaaaatc atcgataatt gccaagcgtc ttaaaatctt aggagcattg 2961001 cgacttgaag atgctaaccc gatttttata ttttcgtttt tcaattgaca tagaagcctg 2961061 ccaatccccg gtaaaagatc ttccggcgtc aatttgctga tcagcatttg ataatcgcga 2961121 tttttccgat gcataagctc ttgtttctcc gcatttgtat actttgtttc cgccccgcca 2961181 aagatcaata tgctttcaag tgactcttct ctgctgattc cttttagcct ttcattcatg 2961241 tctctgtcaa aagggatatc gatttgttct gcgatgtgct tccaagcgag aaaatgatat 2961301 tcagcagtat ctgttatcac tccgtctaaa tcaaaaatga ccgctttcat atactaatgc 2961361 ccatcacagc ttcataaggt ttgaggctaa tactctttaa gtcagcccgc tcctgcggat 2961421 agtttgaaat tagcactttc caacgctcat gaatcagttc tggaggcgct tcgaacagag 2961481 ccttttcttc cgataaattc acaacgacaa gaagcttttc ccctcgatat tctcgaaggt 2961541 aagaaaagac ctgcggatca ttctcctgca acagctgata atcgccatat atcataatct 2961601 tatattgctt tcgtaattga atgagcttct gatagtaaaa gaaaatcgaa tcttgatctt 2961661 ccaaagactc tttcacattg atatcttgat agcgggaatt taccggtatc cacgggtctc 2961721 cggctgtgaa tcccgcatgt tttccggcat cccactgcat cggtgttctc gcatgatccc 2961781 ttccttttat catcacggct ttgacaaact ctttttctga catcgttttg ttttcgacga 2961841 ctagttcacg atatgcattc tttatttcaa gatcatcata catctccagc ggcatatcgc 2961901 tgttgaccat gccgatttct tctccctggt aaataaacgg cgttcctttc atgccgtgca 2961961 gaaccgttgc aaatgccttc gcacattcct tacgcagttt cctgtcattg ccccagcggg 2962021 aaataaccct cggctggtca tggttctcaa aataaagggt attccagccg acattcatta 2962081 acccggtctg ccaccttgtc atcgtctttt ttaaagcaat caaatcaaac ggcttgatct 2962141 gccatttccc atttggcgag ttttgttctt tatcaatatc catatgttca aatgtaaaga 2962201 tcatattcag ctcttgcctg cttgcatctg tgtacttttt cgcctcttca atatcagagc 2962261 cgtttgcctc tccgactgtc atgcagtcgt aatgagaaag cacttccctg ttcatctctt 2962321 gaataaactc atgaagacgt gggccgttag agtgataacg gccgacaata tagctgcggc 2962381 tgtgatccgt ttcgtagtcc ggaaaatcgg tgtatttaga aatagagcca atcacatcca 2962441 tccgccagcc gtcaacgcct ctatccatcc agaatctcat tacatcataa acttcccggc 2962501 gaacggcttc gttttcccaa tttaaatcag gctgtttttt cgaaaagtag tgcaaataat 2962561 actgccctgt tccttcatcg tatgtccacg ctgagcctga aaagatcgat ccccaattat 2962621 tcggctctga gccgtccggt ttaggatctt tccaaagata ataatcccgg taaggattgt 2962681 ccttcgactt gcggctttca gcaaaccaag catgctcatc tgatgtgtgg ttcacgacca 2962741 aatccatgac gattttcatt ccgcgtttat ggacttcatc aatcagctga aacatatctt 2962801 catttgtccc aaacttttcg tacatgtttt tgtaatcgct gatatcatat ccgttgtcat 2962861 cctgcgggga atcaaatacc ggggagagcc agatgacatc cgccccgagg tttttgatgt 2962921 aatccagctt ttgaatcaca ccttgcaaat ctccgaatcc atctccattg gcatcataaa 2962981 aactgcgcgg gtaaatttga taaacgacag cttctttcca ccattcactc attaggcgtt 2963041 ctcctttcac atcgtccctg taggacaacc ggttcctcat aaacgttcat gtgcagcggc 2963101 tcgcctttta caagctcaaa aataacgcgc ttttcgtcaa ccgtcacatt gattaatcga 2963161 tttcgataat tgatgttgaa tgaatattcg tcccattctt tcggcaaaaa cggagcaaat 2963221 gacagcgtct cattcgcggt gcgcatgcct gcaaagccat gaacgattgc cagccagcta 2963281 cccgtcattg aagtaatatg caagccttct tccgtatcat gattgtaatt atcaagatca 2963341 agccttgctg tgcgcttata taattcgagc gctttctttt ccagcttgag ttcggctgcg 2963401 agaatcgcat ggacagaggg cgataggctt gattcatgaa cagtcatcgg ctcataaaat 2963461 tcaaaatttc gccgtttttc ttccattgta aaacggtcat taaaaagata aatgccttgg 2963521 agaacatctg cctgcttaat aaaattggag cggagaatct tgtcccatga ccaattctgg 2963581 taaagaggcc gttccgctgg atctaattcg tcaactgttt gcaggtcttt gtccaagaac 2963641 gtgtcatgct gaacgaaaat ttgcagttct tcactaaatg gatagtacat gtgctggatg 2963701 atttctctcc agacttccaa ttctacttcc tgcacatcca gatggcggcg tttctccgct 2963761 gagatacttt cgagactttg tagagtatac tccaacgtcc aagccgcaat gacattcgta 2963821 taccaattgt tgttaacgtt gttttcgtat tcattcggcc ctgtgacgcc atggatcata 2963881 tacttatttt ttcgtttcga gaagtgaaca cggtcggccc aaaatctgct gactgccaca 2963941 agtacgtcta tcccgtattc ttccatatag ttacggtcgc ctgtataatt gatataattg 2964001 tagatcgcat aacagatcgc gccattgcgg tgaatttctt caaaggtgat ttcccattcg 2964061 ttgtggcatt catcacctgt gaacgtcacc atcggataaa gtgccccctt catccccaat 2964121 tttgcagcgt ttcgtttggc agcctccaac tgatgatagc gatacaaaag caggtttttc 2964181 gtcacctccg gctcggctgt cgccaaatac atcggaacgg cgtacgcctc agtatcccaa 2964241 tatgcggcac ctccatattt ctcgccagta aatcctttcg gcccgatatt caaacgggca 2964301 tcgcccccgt aatatgtcga gaataactga aagatattgt agcggattcc ttgttgaagc 2964361 tcctcatctc ctttaatctc aatgtccgct tttgcccatc tttccttcca tcgatcagtg 2964421 tgcctccgtt ttgcatcttc atagccgttc tctaccacat ccgccaaaag ctccttggct 2964481 ttcgataaaa gctcttcctc ccgaaaatca cgggaagtcg tgacaatcac aaactttttc 2964541 aatgatgcct tcgtttgata actgtagcga ttctcgacat acatttcagt cgttttaaag 2964601 ctttcatgga caaaaccctc cgtctcgttt gccattgcgg ctaataccgt gaagcgcggt 2964661 gttccaaatg gattttcgat cgtttttgcc gctaaatggc cgctgtgaga atcagcacct 2964721 ttcgcttcct cctgccaaaa ctgttcttgg tagttagaat cttcatttgc cacatttcca 2964781 tccaggtaag gaacaagcgt aatgacagca tctcccgtca agcactccgc ttcataatga 2964841 atcgcacaga gttcttttac agcaaggcta agaaaccgct ctgacctgat tctgacggtt 2964901 ttatcttgaa tgcggacaac agcgcttcgc cgcagaatcc cctctttcat attgagttct 2964961 acctcaaata attcgattgg gttttgatgg agatcgattt tttcaccgtc aacatatagg 2965021 cctatgccca taaagttcat cgcattgatc acttttccga aatattctgg atacccgttt 2965081 ttccaccagc ctactcgcgt tttgtcgggg aaccacacgc ctgcaatata tgtgccttgg 2965141 tgactgtcgc ctgaatagcc ttcttcaaaa ttccctctga cccccatata gccattggca 2965201 agagacgtca ggctttccag cagccgtgta tgctccttat taaatgtatt tgttttgatt 2965261 ttccattcat caatctcaaa taaccgctga tttatcatca tttcctcccg aatgtaagtt 2965321 tccattatca cggcgggttt tggtcaaata tctaaatgca aaagagatca tcaaagtaac 2965381 gccacacgaa tggatcatca atacagtaat caaatcaaaa tgaaccatgc cgatagcagc 2965441 tgccgcaaat gccggcagtg ctgatgcgca aatcgctata gaggccgctt ccttgaatga 2965501 tgcaatagag accatgtttg atatttttgt gatccagagg ccacctgcaa gaacaaacgt 2965561 taacaaaagc tggatcatag aaaccaccgt atatgccagc atcatgatca tcggcttata 2965621 ctgtgccaac cacaatgtat cgatcaagac ctctacatca tggacgtttg gtttctcgag 2965681 cttaacgtcc attttcgcat agccaacaga aaaccccgtt tcgttttgat cggtgatcac 2965741 cagttgatca ggttgaaata tgatggcgtt ttcaaatcca gttactttca atcgcccatt 2965801 ttcaccgctt gtctcatatt catgcttcat atcgactgcc atcacattct gcccatcttc 2965861 aatcctctca gagctcttcc cgcctgttag ttttccgttc ctgatttgaa aaccctgcaa 2965921 ttgatcagca aattgatcat taactccttg aatcgctgac ggcatgaaag atgaaacgct 2965981 gaagcgatcc attttcacaa acgaaaccgc taacggcgcc attaagcagg ccgttaaaaa 2966041 cagaaagaga aaagagagct gcagccagct gaaggtattc ccatagcggc aaacacctga 2966101 tggggatgca gccgccttca ggcagcggat gataaagctt ttattctcca gattcttcat 2966161 tggcattacc cctttgttcc gccggctgtc aaaccggaca caaagttctt ttggagaaaa 2966221 aagaatagaa cgcatatcgg cagtgcggct agtatggcac cggctgcaaa tagagctact 2966281 ttttgctgct gcggattaga aataaaggat tgtaatccta cagcgatggt cagcctttcc 2966341 ggtgagcgaa gcagaaattt cgtcagcaaa tagtcgccaa acggtgccat aaacgcccaa 2966401 agcgcttgta ccgcgagcat tggcttaaca agcggtagaa caattgaagc gaaaatcctc 2966461 agatgtcccg ctccgtcaat tcgcgcggct tcatcaattt ctctcggcac agtatcaaaa 2966521 taacctttca tcagccacgt gttcatcgga attccgccgc cgatatagat cgctgttaaa 2966581 aaccagtatt gatcgagtgc gcctattagc atcgccaaga cataaaaagc agtcagcgcc 2966641 gccattgtcg gcaccatttg aatgattaaa aagaatatca ggctcttttt tctgcctgca 2966701 aaccgatagc ggctgtacga gtacccggca agtgtcacaa tcgtaacctg caaaaccatg 2966761 accgatagcg cgatgacaag tgtattgctg taccaattga gataaagcgt ttcgtcaaat 2966821 agccgcttaa aatgatccaa tgtccaagaa cccgaaaaat cgagctgaaa agccgccgaa 2966881 ttccccacac ggaaggctga tgatgccgta atcagcaacg gatatataat gacaatactt 2966941 aaaagcgtca aaaataaata cgtacagatt ttattaagca ttctggcagt gctcgcgttc 2967001 acctacataa cctcctcatt gccaaaagca ttcgattttt tgaaagcaat cagtgaaatt 2967061 ccaatgacaa tgaaagaaat taacagtgtc acagccgccg caacggaata ttggggtgat 2967121 gtgcctgttg tcagtttata aatccacgaa attaagatat cggtcgatcc ggccccggct 2967181 cccgcactgc ctggccctcc ctcattaaat aaatagatga tcgagaaatt attgaaatta 2967241 aacgtatact gagtaatcat cacgggtgct gtggcaaata aaatcatcgg gaatgtaata 2967301 tgccgaaaac gctgaataaa agtggccccg tcaatctttg ccgcttcata caattcacct 2967361 ggaatcgcct gaagcactcc cgttaccatg acatatatat atggaaagcc gagccacgtt 2967421 tgaatcataa tgagggctgt ctttgtccag aaaggatcgg tcttccacgc gatcgcaggc 2967481 agctcgacaa acggcaggtg attgaataat ggtatcacct gtgcattcac cgctcctatg 2967541 ctgtcgttaa acatgttgga aaaactcatg attgtaataa acgccggaac agcccatgga 2967601 aataagaaaa tcattcgaaa tatccgcttg ccttttataa aatcctgatt gacgaaaagt 2967661 gccgtcacaa tacctaaaat gatttgcagc gttgttgcac agattgtcca gataaccgtc 2967721 cagcccagta cattcacaaa tgtttcacga taggagccaa ggaaaaaaat atttaagaaa 2967781 tttttaaacc cgacccagtc aatcagacga ttaggcggaa tatgataaaa atcatagttt 2967841 gttaatgcaa caaacagagt caccaaaacc ggaaaaataa tcacaaacac catcatgata 2967901 tatgccggca gtgtaaatag atacggaaaa cctttatcgc ccgcatgaca gatcatatcc 2967961 ttggctgttg tattgacttc caaacccgcc gctttcatag cggcggtctt acgtgaatca 2968021 tgaatattaa agatatagaa catgaggaaa atcattgtca cgatcaattg cagcgtgcct 2968081 tcaatcagca taaacagcga gtgatcttca ccgggaacac ttcccaatgt catcaatccg 2968141 gttagcgcct gtataccgaa aacgcataat tcaaaagcaa acaagcctgt gatggcaaga 2968201 aataagagcc cctttgacaa ctgctgattc gcaatctgcc caagtcctgg aatgatcgat 2968261 aaaagccctg cctttcgttt ttgctttgta agtgtgtgat gtttattcat ttttccgccc 2968321 tctattcttc cggacgctat cccgccgttt tatttcacat acttttcttt aatattttcc 2968381 tttatgacgt ttacagcatc attcgctgat gtttgtgtcg atttttttcc tgaagctgca 2968441 tcaaaaatta aactttccgc tcctgtccat acttcagcca tttccggaat atttggagtc 2968501 ggcgttgctg tttcatattg tttaatcaca gctgacgtca gttcattctt ttgctcatcg 2968561 gctttcttcc ttgcagccgt gttggccgga acttcgtttg tatcctcata aaaagcgtaa 2968621 gcattggcat catttgcagc atactcaagc catttttcag ccagctcggg ctcttttgta 2968681 tatttcgagg caacccagcc cttcccgcca gcaaaagggg cgtattcttc tccatttggc 2968741 aatgtcggaa tgggagccgc tccgtagttc aatttagcct ctttatagtt ggcagctgac 2968801 caaggaccgc caatgatcgc agccgctttg ccttctaaaa acatctgctg aataaagtcg 2968861 tctgcgcttg aattgtcttg cattcctttc ggccaatatg tctcaaacca tttctccgca 2968921 tatttcaccg cttctacagc ccctttattg ttcaggccga tgtccccgga atctgtgccg 2968981 ttttttccaa acacatatcc gccgtatcca gccaataagc cgtacgacat ataaaagtca 2969041 gtccattttg ctaaaaatcc ggttgatttt cctttttccg aagcaaacgc gaatcgagga 2969101 tcttccgtta acttttcaag gtctttaaat gtttttggcg ctgtttttaa aagatctttg 2969161 ttgtaataca aaataagtgt ctcaatgact agcggcattc cgtacacttt gccgtcaact 2969221 gtcacctgct gcatttcttt atcaccaaag ctttttgtgt tagatggctt aatatcaagt 2969281 aaatgtcctt gttgtcccaa accgccgatc cggtcatatg cagcaagcat aacatcaggc 2969341 gcattacccg ccgggccatc aagaggaagc gcttctaact gttcgaacat ttgcttttca 2969401 acaattttta ctgtgacatc attttctttt tcgaactttg tttttatgct ttcaatgtat 2969461 tctttatacg tttcttcgac agacacagtc agcacctttt tgccatcaga gcttgctgga 2969521 ttttttgaac ttgagcaggc ggcaaggccg attgccagga atgatgccgc caatatggcg 2969581 aacccctttt ttaaaagaac catctctttt cctccttcta tttacgaaac tataacaatt 2969641 gtattgtcct atagaaagcg gttacaacaa ctttcgattt gttaccgata acagaatgtt 2969701 atacaggggc ggcagcactc aaaatcaaaa attctcccgg ctgaacggca atgacatcgt 2969761 gatgctgtag cggctgctct gtccatgcat cacagatttt cttattccta tcaatattca 2969821 actctcgtaa actgacgtgt tgaaccacat tcccttgatt aaagaaataa atcagtattt 2969881 tttcatcaag agtccgcgaa aagctaatga aatcattttt gtcgtccagc agattccact 2969941 caagatgtcc ttcagtcaat aaagtgtttt cctgcttgcg taaagcaatt aaccgtttca 2970001 taaattgcag catgtcttgg ttttgcttct ctttttccca aaccatacat ttccggcata 2970061 atggatcatt ttcgccgttc agcccgattt ccgttccgta ataaatgcat ggtgagcctg 2970121 tctgggcaaa cataaaggcc agcaacgcgc gtgctttctt ctcatcattg cggcatctgg 2970181 tcaaaaggcg ctttgtatca tggctatcca gtaaattaaa catcacctca ttggcctgct 2970241 tcattccatt catcaaatgt gcattgacac ggtgagccat acgtgaagct gagatcgtct 2970301 ggtcagcaaa gtattcaatc ataggctctg taaaagggta attcatcgcc gcatgaaatt 2970361 catcccctct aagccagggt tcggcagaat gccagatctc acctaaaata taaacatcag 2970421 gcttttcagt agatacagcc tgcctaaatg tcttccaaaa aacgtgatcc acttcatttg 2970481 cgacatccaa acgccagccg tcaatgtcaa attcgcgaat ccagtacaaa gcaatatcaa 2970541 gcaaatattt ctgcacctcg ggattagccg tgtttagctt cggcatatca gctgtaaaag 2970601 caaatctgtc ataattgtcg tctgtgacgg gaaaagagtg aatatggaac cagtccttat 2970661 agcgggattg atctccgttt ttgacgacat cctgccattg cggagacgcg cttcctatat 2970721 ggttaaaaac cgcatcaagc ataattctca tcccccgctg atgcagctgg ctgaccaatg 2970781 tacgaaaaag ctcaggatcc ccgaaatgcg gatcaataga aaagtaatcc agcgtgtcgt 2970841 atttatgatt agaaggcgcg gaaaagatcg gtgtcagata aatgccgttc acccctaaat 2970901 cctctaaata atcaagcttg tcaacaattc cttgtaaatc ccctccaaaa aaatcattga 2970961 cgtccgggtc cttgctcccc cacggcaatg cattcttcgg tgacaagtct tctcttccat 2971021 ttgcaaaacg ctccggaaaa atttgatacc aaaccgttga cttgacccat tcaggcgctt 2971081 gaaatgtatc agcctcgtga acaaacggaa atttaaagta ataatgaatc gtttccagtg 2971141 ttttttcgtt ataagggcat acacccgaac ttccgaaaaa gatgtcttca tgatcgtctg 2971201 ttacaacaaa cgcatattgt aaacgcctaa atggcggcac cacttcagca aaccaatagt 2971261 catgcatttc tgtagcagca attttcctca tcggctgctc gtttgccgac catttgccgt 2971321 cgttgtactc atagggatca ccccaaatga atcgaatgtg atctgcatca ccttttttcg 2971381 tccgaatctt gatatgcaca gtccgcccat cataagaata agcatctgtg ctgaatggct 2971441 ggtgatgaat cgctgcatat tccatcatgt ttcccccttt gatttccgtt ttattgaagc 2971501 cggctcatag tttgaaagta tcatgatgaa attgtgggaa caatcctttt caccctgtta 2971561 ccgataacag aataaggcgc ttacagcgtt gattctcgta caattaactc tggttcaaaa 2971621 aatagacttc cttgtgcagc gccgtcttca ttcatttttt tcagcaacat tttcgcacag 2971681 gcttccccca tttcaacaac aggctgtctg accgtagtca agcgcggcga ggagatgcga 2971741 tcaagaaaca caccgtcatt cccggtaacc gcaacgtctt ctggaattcg ctttccaagg 2971801 gattgcgccg cacgaatgac gccgagcgcg attcgatcag atgcgcagac aaatgcggcc 2971861 tgattgtcca tggatttcag cagttctctt gcaaggcatt cacttttctt agaactgttg 2971921 tcgatccgaa acatattcga ttttttaaag cttttattca tcgcccgtat atacccctgt 2971981 tctcttgcac gttcgaaagg ctcatctaaa tcaatgccaa aaaagacaac ttcccgctcc 2972041 cccagcccca taacatggcg ggttgccata aaagtgcctt tctcgttatt cacatcgata 2972101 aagtcatagc ccatttcatt ttgtccaaat acgacgagcg gcttctcaaa agcttttatt 2972161 acaccttcaa aatcgttctt tctcaagccg gtggcaataa tgccgtcaca ttggccaata 2972221 ttaagagaat ttcttgtcac aagctggaga gcatagtgat tgcgatccag ctccctgctg 2972281 attcctgtca gcaggttcat gtaatatggt tctgtcgtat ccatttcctc aagtatcaat 2972341 agtttcacaa cctgtgttct gttttgcacg agcgctctcg ccgcataatt agggatgtaa 2972401 ttcagctctt tcatcgcaga atgaacaagc tttttcaatt catccgtcac cgtctcaggg 2972461 tgattgatca ctcgtgatac cgtcattttc gaaacatttg cttttttcgc cacatctgac 2972521 aatgttgcca ttttcatccc ctccttatct gtgcttatta tccaaactag tgataaagtc 2972581 ctctattact gctaaatata cgatgcaggc caaagagaaa taaaaaagag atttccctta 2972641 aggaaacctc actttgttaa aaacactcga tttttcatgg attcatacgc taggtggcag 2972701 actcattctc tccacttcca tcagaaaatc tcttttttaa atttctgtcc actttttttc 2972761 taaaatcgga taagaataat tttgcatttg ctcaattaac tcatccggcc gtgacgagct 2972821 gtgaatcagt tttaggtgcg attcgttaga aaacccttct tgaatgctgt atttcaccat 2972881 tttcatcatt ggttcaaaat atccgtttac attgtacagt ccaattggct tttggtggat 2972941 gccgatctgt gcccagcaca gcacttcaaa taattcttca tatgtaccga agccgcccgg 2973001 catcgagata aagccgtccg ccagctcgct cattttagcc tttcgttcat gcatcccgtt 2973061 tacttcaatc agctcagtca gattctgatg gacaacctcc ccgctgaaca aaccgctcgg 2973121 catgaccccg attgcagttc cgccgttttc cataatcgcg tcagcaatcg tgcccatcaa 2973181 gcctacgcgg gagcccccat agacaaggcc gattccctgc tcagccatat acacgccaag 2973241 ctctgccgct tttcttttat acgcttcatt tcccccaggg tttgatcccg caaatacaca 2973301 aatggttttc atcttgtcat ctccgcatct atatatcgtg ttaaacattc aaaaacacac 2973361 tatatattgt cccatcttca tgtgataata tcaatatgaa atacataaag aatgcaggag 2973421 tgatgaggtt gcagctggct gatgcagaaa aatggatgaa agagttttac gaaaaaagag 2973481 gctggacaga atacggacct tttattcgcg tcggcttttt aatggaggaa gccggagaac 2973541 tggcccgggc tgtcagggcg tatgaaatcg gcagagaccg gccggatgag aaagaatcgt 2973601 cacgcgctga gcaaaaacaa gaattgattg aagaaatggg agatgtcatc ggaaatatcg 2973661 ccattcttgc tgatatgtat ggtgtctctt tagaagacgt catgaaggcc caccaagaaa 2973721 aactgacaaa acgatttgag catgcataaa aaagcggccg cgatggccgc tttttttaac 2973781 ctgtgatttc atcatggtga tcaaagaaat gctgctttcc tattttgtga aaaaggcctg 2973841 ttttatgcag tagctccttc ggctgcgatt gcaatcctac aatcatcagc tttccattgt 2973901 ggcgtttaat tcgattcata atgttcccaa gcaccgcttc agctgacgta tccatatagt 2973961 gcaccttatt catgagcaga ataagggttt tcggtttttt ctgtacatgc tccagcaatg 2974021 acgattcaag ggaatcaatt gatccgaaaa acagcggccc ttctatggca tacatgctga 2974081 cagatggatc ttctctcttc gccagaacag gatgcgtttc ctgattgtgg atgcgggtcg 2974141 cttcgctcat tcttctgata aagaacacga atgcaagcag caatccggtt gccacaccga 2974201 tgattaagtc aaacagaacc gtaagggcga aggtcgccgc caaaataaag gaatcagcat 2974261 ttttcagtct cagcatgttt gcgacttcct tgcgctcact catattccat gcgaccacca 2974321 tgagaatcgg tgccatactg gcgagcggca catgggacgc ataaggcgca aatacaagca 2974381 ggacaaggag aacgactacg ccgtgaacga cgccggaaac tggggaaacc gctccgtttt 2974441 ttatattggt cgccgttctc gcaatcgctc ctgtagccgg gattccgcca aacaggggcg 2974501 ctgccatatt cgcaatcccc tggccgacaa gctccttgtt gctgtcatgc tttgagccct 2974561 tcatgttatc agcgaccatt gcggacaaaa tcgactcaag tcctccaaga agcgcgatga 2974621 caagcgcagc cggaaacagc ataaccattt tatccaaagt aagctcagga aactgaaatt 2974681 ccggcaaatg gcgggggatt tctccataag ttgacccgat cgttgccatg cggtcaggga 2974741 aaaagacaac cgcgaccact gtggaaataa gaagcgccaa caaagcgccc ggcactttag 2974801 gcatcacctt ggcggataca agcaaaatga cgagcccgat cacagctgtc aaaatggcat 2974861 acacgttaaa ggtgccgagc tgctgcacaa tttcaaacat gttgtgatga aagttctcat 2974921 gtttttcaac atttctcaat ccgagaaaat tagcgatttg ttccgtaaag atcagcacgg 2974981 caattccggc tgtaaaaccg acgataacgg gtttgggcac gaatttcatt atttttccga 2975041 gcttaaacag cccaaacagt accagcatca ctcctgccat aaaccccgca atcagcagat 2975101 tttccaagcc gtactgcatg ataatgccga ataaaatcgg gacaaaggcg cccgtcggac 2975161 cgccaatctg atattttgat cctccaaaca aagaaataca aatccctgct ataacaacag 2975221 tgtatagccc atattcaggc tcgactcccg aggcaatggc aaacgccatt cctaaaggaa 2975281 ttgccacgac acctactacg atacctgcaa tcaagtcttt ctgaaatttc tgcaaattgt 2975341 atcccttgaa tctccctgag aatcgcatat tttgttataa cctcccttat gagtgattgt 2975401 ttataagctc agtttcataa ccgttaatga ccacatcaag ttttcctgtt tcagggtgaa 2975461 tgacaagccc gtgaaccggc acttttttcg gaagcagcgg atggttctta atcatgttca 2975521 cactgtggga aacgctttct tccacgctgt gaaaaccagt cagccacgtt ttcaaatcga 2975581 gtccggcact cgtcagcaaa ttcaggcagc tatcctccac cccgcgttcc tttgctttct 2975641 caagaatcga ggacgcattc agccctgaca ttccgcattc atgatggccg acaatgcata 2975701 cctcttcagc ctgcaattca taaatcgcga ccagtatgct tcgcatcacg cttccaaatg 2975761 ggtgagaaac gatggctccc gcgtttttta caattttagc atcaccgttt ttaagcccca 2975821 ttgcttgcgg aagaagttct gtaagccttg tatccataca ggtgacaatg acgagctttt 2975881 tcgaaggaaa ctttgtcgtt ttgtacggtt catacttctt ctcactgaca aaccgctgat 2975941 tgtgttccaa aattgatgtt aaagaaacca tttgattcat ctcccatcca tatgattttg 2976001 caagccttct tacccagctt acagtaagga attatagcat aggaataagc caagaaaagg 2976061 ttttcaaaaa aagacactat aattggactg tagaatcaaa acataaacat ttatatcttt 2976121 caaagataat aaaatttata tttaatgcat cctataatcc ggctgcagtt cgtatatcga 2976181 tgatttgtct gacaaaaaat atgggtgaat tctgataatt aaaaaacttt tttaagcaga 2976241 tttagctgtt cgatcttcat tttaagttca aaagaaccag aaattaaaaa aacgcagcta 2976301 tatttttaac atctatttat tttcgatata atgaattaga caacagccat aaagggggag 2976361 ccttgttgaa accatttgta tttatcacaa aaccgattcc tgaagagatt gaagcattca 2976421 tcggtgaaca ttgccgttat gaagtatggc aggaggatac gcttccgagt gacgtgctat 2976481 ttgaaaaatt aaaagaagcg gaggggcttt taacatcagg gacgtccgga ccgtcaatca 2976541 atcgtgagtt gctggaacac gcgcctaagc tcaaagtggt cagcaaccaa tcagtaggct 2976601 acgataactt cgatatagaa gcaatgaaag aaagaggagt cgtcgggact catacacctt 2976661 atacactgga tgacacagtt gcagatctgg ctttttcact gattctgtct tccgccagac 2976721 gtgttgccga actggaccgt tttgtcagag caggaaaatg gggaaccgtg gaagaggaag 2976781 cgcttttcgg aattgatgtt catcatcaaa cgttaggcat tatcggcatg ggcagaattg 2976841 gagaacaagc agcgagacgc gccaaatttg gttttgatat ggaagtgctt tatcataacc 2976901 gacatcgcaa acaagaaaca gaagacagca tcggcgttaa gtatgcagag cttgatacat 2976961 tgctggagca atctgatttt attcttctca ttacgccgct gactgatgaa acctatcaca 2977021 tgataggaga acgcgaattt aagttgatga agaattcagc aattttcgtc aatatttccc 2977081 ggggaaagac agttgatgaa aaagcactga ttcgcgctct tcaggaaggc tggatcaggg 2977141 gagccggctt agatgtatac gaaaaagagc ctgtcaccca agataatccg ctcctgcagc 2977201 tggataatgt cacgctgctt cctcatatcg gttcagcaac agctaaagtg cgcttcaaca 2977261 tgtgcaaaca ggccgccgaa aatatgctcg cagcgatcca agggcaaaca ccgaaaaatc 2977321 ttacaagaga atttcaataa atcaaaaatc cggtctgata acagaccgga tttcatatta 2977381 catacgctga agaacagcac gcttataaat atgacgggtg acgatataat aaagagcctg 2977441 gaatacaaaa taaatgaaga tgacaattac ggcctcaaga aataaattgg aattcagcat 2977501 attacttaac gctgcatacg caaagcccgc gtgaatcgta cctgcgataa atgggatgaa 2977561 gaataaaaat cctatttgct ttccaaggat cgagtgaatc tctttgtccg taacccctat 2977621 cctctttaac gctaacacct gcactcccgt atcttctatt tccgtaaaca tccgcaaata 2977681 cagcatgctt ccttgcacga taaaaaacag cacgctgaca aacagaccaa taaacagcat 2977741 taatgcaact ccctgcttca caatttgata actaggagca cgtgtttgaa aatcagatgt 2977801 atgttctttc ggcaccatgt tttcaagctt ttcagagaca tccaccgtct cctgccaatg 2977861 ctcaagctca taacctacca ttctcatctg ttccttcagc ggcacatcct gtgacagact 2977921 gtcaaagctc ttttcgctga caaccaataa acggctgact ccatcgacag acatcaatat 2977981 ccctttgttt tgctgctttt tcatgacata ggaaagggtt tttcctgact tcatatgaaa 2978041 tgctgctgtt tccccttctc caaatgtgtc tttcaccatc atttgaaaag aaacattaat 2978101 aaatgcttca ttttcttgta aatgaataac tgggaaccct ttttcctttg cgacttgatt 2978161 atagactttt tctgaaatca gcaaagcttc agcttccatc ttcttatttc catacggcaa 2978221 gtctgactga aaagtgacag gaatccctgt ggcatccacc ttatacgtga taacagcatg 2978281 agcttttttc aatgtattct cagccgtctc aggcttcatg acctgaaagc gggaagcatc 2978341 cttttccacc caggaaacag actgaggaat gctttgctcc tcctgccttt gtaaatcgga 2978401 ataaaacata tagatgacac ctgtagctgt tagtatgacc gctgtaatga cagaggttaa 2978461 aaacagcatg cgtgcatgat ccttcagcct gaatatcatg ttggaacgca caatgatatt 2978521 tgtgcctttg tagaagctgt gtttctttcg gtacagcatg cggaaaaatg ccacactgct 2978581 ttgggtaaaa aagaaatacg tgccaattaa cactaaaatc aaaattggaa aaacccgaaa 2978641 catcatgtca attgcattgg ctgttgcaga tagataataa ccgctgccaa gacatagcaa 2978701 agacaataca gtgagccatt tcgaataaac tggcaaactt ttcggctttt tggctgattt 2978761 aatcagttca atgatttcca gcttccgaat ccgtcccagt gataaaatga gcagcgtctg 2978821 aaacaggatg agaaagccgg caattgtcat cacaaacgct ttcggcacaa tggcaaacga 2978881 aatcggcacc ttcacgctga gcatccatgt catgatcata aaaaacagtt ttgaaaataa 2978941 caggcctgct ccaatgccgg ccgcaatcgc cgcaagagaa ataagtgact gctcataata 2979001 aatcatcttg cgaagctgct gctttgatgt gccaaacagt gtcagcagcc caaactcttt 2979061 ctttcttgcc tgcaaaaacg ctgaattgga atatgtgatg aaaaatatac aaaacacaat 2979121 gatgacgaca agagctgcgc tcaagcatgt tttgacaagg cttcctccat atatattgtc 2979181 ttcattgaca tcaggatgaa aaataaatga tgtgaagaca aaaaacaccg aaacggcaaa 2979241 cacacagctt aaaaagtagg ccacataccg ttgcagattc ccaagaatgt ttttacgggc 2979301 gatagttctc aaattcatga aaatcgcctc ccaacacact caaggtatcc aatatacttt 2979361 gataaaacac ctgcctgttt gttcctctgt gaatctctga aaagaaacgt ccgtctttaa 2979421 taaaaacaat ccgtttacag aaacttgctg ctgtggcatc atgcgtaacc aacaaaatcg 2979481 tcgcttcctt ttcctcattc agctgagcca gtgtgttcat cacttgcttt gccgattttg 2979541 agtcgaggtt tcctgtcggt tcatcggcaa gaatgagcgc cggattgtga ataatcgctc 2979601 tggcacaagc tgcccgctgc tgctgtccgc ccgacacctc atatgtgcgg tgatcgagaa 2979661 tatgctttat ttgcagcgta tccgccagtt catccaatcg agcttccatt tctctcagct 2979721 ttaccttatc caatgcgagc ggcaagagaa tattttcacg aatcgtcagc gtatcaagca 2979781 gattaaaatc ctgaaagacg aagccgagtt ctcttctgcg aaacaaagcc agctcttggt 2979841 cctttaacgt tttcggctga atgccgttga tcatcatctc gccctgggtc ggcttatcaa 2979901 tggtagccag caaattcaaa agcgtggttt ttccgcttcc cgacggcccc ataatcccga 2979961 caaattctcc ttttgacaca ctgagatcaa aggcgctgag cgcttggtat gatattgttc 2980021 ctttatttga atagtatgtt ttcgataggt tcgttgtttg caacacgttc atgttctgct 2980081 cctccttttt ctttattata aaaaggaagt cagcatcctc ccatcgaact ttcttgcaat 2980141 tccgctcccc aatcttacaa tgctgtcaca ttcacgaggg tgtcacttga aaacacgatg 2980201 gtcatcacag tgccagcccc ttcttttgat tccgcataca gcttatggcc gagacggctg 2980261 cacacctgtt ttgctaaata aaggcccatt ccagttgcct ctttcatggt tcgtccgttt 2980321 tctccggtaa aaaacgcgtc aaaaatccgc ggcagatcct gcggcggtat gccgattcct 2980381 tcgtcggcaa ccgacaagcg cgtctcatgt ccctgtgttt caatccggat tgtaataggg 2980441 tctcccacac cttgctttga atattttaag gcgttgaaaa ggatttgctc aacaacaaag 2980501 gaaagccact tttgatcact ggaaatctga acggcatttg gcggcacatg taatgttgga 2980561 aaaaggcgcc gcttgataaa ctgacgtttt tcctgattga tcagtgaacg aaccatttct 2980621 gccaaatcaa aggtttgcgg ctttacatca aatgcaaatt cctccagccg ggccgtttgc 2980681 agcatcatat caagaccgtg gcgaaatctc tcattctcat cctccagctc ctctaaaaac 2980741 gtcggaaaag aggatgaggt tccgtttttt ccttcctgaa tcattaagga tatgacagat 2980801 accggtgttt tcatatggtg gacccattgg ttggtgaagg tgtaatgctg tttttgctga 2980861 ttgatatatt gtgagagcct gctttcgtat tgctgcccga gtgcgttgat catcttcgtc 2980921 caaagcgctt gctctcctgt tcttggcttt ctggctttca aagactgtcc gatgtcattc 2980981 gaagaagagg cttgttctgc aagcttttta acatatgtga gaaaggaaaa ttgccgaaca 2981041 taatcagcag caaaacctgc ggctaaaaga gtaccgggca aaatccatat gtacatcata 2981101 ttttctttgg aaggttctgc gccgctctct acaatgctta aatacgcaat cagcatggcg 2981161 gaccctatcc ctaataatga aaatagaata atggctaagc ggtcgatgag ataagtcttt 2981221 aacattccgc ttcatccttc cgattgactt gaaattgata accttgtcct ctgattgtgg 2981281 aaatgcaatc tgtcagtcct gcattctcca gttttctccg cagccgattg acattgaccg 2981341 ttaacgtatt gtcatcgaca aaatcaacgt catcccataa cgcctccaat agttcatcac 2981401 gagagacaat ttttttatgc tccctcacaa aaatcgagag aagctggaat tctttttggg 2981461 aaaacaaaat ccggacgctg ttccattcgg cctcattctg atcaggataa atcgtcagcc 2981521 cgccaagctc cactattcta gattcctgcg gcaaagaggg cgaatattca ccatatgtgc 2981581 ggcgcaggac gcttttgatt ttggccatca ctacctctag atggaacggc tttgtgatat 2981641 aatcatcgcc gccattttca atcgccatta cctgattcag ctcatcggtc cgtgccgata 2981701 taaagataat cggcgcattg gaaatggtac ggatttgcct gcaccaataa aacccgtcaa 2981761 aaaaaggcag gttgatatca agcagcacaa gatcaggctt catttctgca aattccaatt 2981821 ttatatcatt cagctgttca gcaattttca cttcatatcc gtatttttga agatgaccgc 2981881 ccagcaaaga agcaatccgc tcatcatctt ccacaagcaa aatccgatac acgttgatcc 2981941 cccttatatg tacatcacga tgatttttct agaagattcc aaaattatta tagcatgtgc 2982001 ggaatagtaa atcggtcttt ttctttttgt tatgatagaa tgataaaggt aaaattttca 2982061 taataggcag gtgtcgtgat gaagaaaatc atgctgtttc tggcaatgac gtcaattctt 2982121 tcagcatgtc agcccaacta taccgggaaa tacatagaaa ttggggatac actaactgac 2982181 tataccaaag agtgctttaa agagaatgaa attccttata aatacgaaaa gggaaaactg 2982241 tatatcccag aagacgcatt tgatacagca atctacactt gttcataaga aaaagcttgc 2982301 agataacctg caagcttttc acgttacaaa aaatgagtat ttaatttctc ttcaaatcct 2982361 gaagggccga tgtcgctttt ttgaatgtta ccgccgtttt cataaatcgt aaaatggcgc 2982421 tctgacatga ccatccttcc gctcggcgtc agctttgagg caagcaggga tttgttaaaa 2982481 ggagattttt catgagagtg aatgatgtcc ttcatgttat ctaaatcacc gagatcactc 2982541 tcttcaaggg taaaggcgta cccaatttgc cagccttctc ctttgtccat cagcagaaca 2982601 tagctgccct tttctgtctc ttcctttttg attcggaatg acccgactgg tgactgtacc 2982661 gtttctccgg aaagcggtat cggctggagc gccaggttga tgccgaagcc gatatcaacg 2982721 aggtaatcgc cgttttccgc agacagccat acagcagcat gcgtcccttc tagtgcccat 2982781 ccctcttgat cgcctgcata aaccgttcct cgaatgagct tcacatgaaa cccggcctca 2982841 cgcaagacaa aataaaggaa accatttaga tcgtagcata ggccgccgtg ctgatctttg 2982901 agcagacgtc gccatagctc ttcttttgtg atcttataat tctcttttgc aagtacggca 2982961 cggttttcga atggaaaacg gtatgccatt gctttaagaa aaaggggaag atcgccgaag 2983021 ctgacatggt ctttctccca gccgattttc tgaaagcagt cttttagaaa gtcactcatt 2983081 tttatcacct aaacttcttc ttgaacgtaa gcagccagct tctccagcgc ctcttgttca 2983141 tcttctccct gggcaatcaa ggtaacctca gtgcctgtgc ttaccgcaag gctcatcagc 2983201 cccatgatgc ttttggcgtt tacttttttc ccatccttct caagaaacac atctgacgta 2983261 aaccggtttg cttcttgtac aaacaaagca gcaggacgtg cttgcagtcc tgtctttaat 2983321 cgaacttcca ctttctgttg aaccataaga tctccccttt tctttacggt tattttaaag 2983381 tgacggtttg ccctgtccgc agctgttctg cgatttcgtc aagttttctc agcctgtgat 2983441 tgatccctga tttgctgatt ttcccgcttg ctaccatttc ccctagctct ttcagcgtca 2983501 cttcctgata atcaatccgc agctgcgcaa tttcccgaag tttttcaggc agcgcctcca 2983561 ggccgattct ttcatcgatg tatttaatat tttccacctg tctcagcgat gcgccgatcg 2983621 ttttgtttaa gttggctgtt tcacaattga cgaggcggtt gaccgaattt ctcatgtccc 2983681 gaacgattct gacatcctca aatcgcagaa gcgaattgtg agcgccaatt acgttcagaa 2983741 actctgtaat cttttcagcc tcttttaaat aggtaatata gccttttttc cgttcaagcg 2983801 ttttgctgtt taactgaaac tcatttaaca ggtcacataa tgaatcgtta tgctccttat 2983861 aaagagagaa gatttctaaa tgatacgagg aggtttccgg gttattgacc gaacctcctg 2983921 ccaaaaatgc tcctctcata taagaacgct tgcagcatct ctttttgacc agctctttcg 2983981 aaatacttcg ttcaaacaca aaattctccc cgagtatttt taaatcctct aagatcgctt 2984041 ttgcattttc tgaaaaacgc acaatataga cgttattctt tttcagccgc attttctttc 2984101 tgaccagcag ctcgaccgac acatcatatt gttttttcag caatgtatag atgcggcggg 2984161 caatcgccgc gttttcggtt tgaacatcga gtacgagatg gcggtttgta aatgataaag 2984221 ctccattcat ccgaatgagt gcagacagct cggcattaat gcagcagtcc ttcacttcca 2984281 gattcgttaa ttcttttttt gtttctgatg caaatgacat atagccacct catttcaagg 2984341 cttcattctt tcagtaaatc aacaagaaga gaggccactt tatgtgtatc gtgacgtatt 2984401 acgtcatttt tatacgttac aatttgatct ctgatgactt caagccccat cgctttcagc 2984461 tcttcgatat caaaatcaac aggacgcgcc gattccattt cgtacttacg ttttatttcg 2984521 tcgggaatgt cttcactgtt cactaatatc gtatcaataa aaccacagcc catatgctga 2984581 ttgagcgctt tcacatgatc agcagcggtg taatggagcg tttcgccggg ctgagtcatc 2984641 acgttgcaaa tgtatacttt tttcgccggc gcctttatca cttcttcccc gatttttggg 2984701 acgagcaaat tgggaagaat gctggtatag aggcttcccg ggccgataat aatcaaatcc 2984761 gcttccctga ttacgtctat tgtttccggc agcggatcaa tctgttcagg cgtgagaaaa 2984821 acacgcttaa tgcgctgtcc gtattctggg atcgttgact cgcctgagac cacgcggcca 2984881 tcttccatct cagcatgcaa aacgacactg gcattggcag ccggcaaaac ctttcctctt 2984941 acattcagca ccttgctcat ttctgtgaca gcgtgaaaaa aatcaccggt tatatttgtc 2985001 atcgctgcca aaatcaaatt cccgagagaa tggcctgtta agtcattccc tttattgaag 2985061 cggtgctgaa aaagatcttc aacaagcggc tccacatcgg ataaagcggc aagcacattt 2985121 ctgatgtctc cgggaggcgg aattttcagt tcattccgca gacggccaga gctcccccca 2985181 tcatcggcaa ctgttacaat ggccgtgatg tcaacgggtt tatgctttag gccccgaagc 2985241 aatacagaaa gacctgtacc gccgccaaag attgcgattt tcggcttttg tcccatctta 2985301 tttccggctt ctcttttcaa tgtcccggtg agtaacatga gtatagtaat cctttttgaa 2985361 ataatcagct aaattctcgg ctaatgtcac agagcggtgc tggccccctg tgcagccgat 2985421 cgcaatgaca acctggcttt ttccttctct tttgtaagat ggaagcataa agctcagcag 2985481 atcaattaat ttctcattga acttttgcgt ttcattccac ttcatgacgt aagaggaaac 2985541 ctctttatcc ttgccagtca gcggccgcat gctttcgata tagtacggat tcggcaaaaa 2985601 tctgacatca aagacgagat ctgcatcaat tggaataccg tatttaaaac caaatgacat 2985661 cacatttacg gtaaatgtct ctccttggtt tgtcgcaaag tgcttcacga ttttttcacg 2985721 caaatcacgc ggcttcatgt cagacgtatc gtaaatgatt tgagagcggc cttttaattc 2985781 ctcaagcagc tctcgttcta gcgcgatgcc ttcaagcggc aggccagtcg ctgccagcgg 2985841 atgcgagcgt ctcgtttctt tatatcttgt gacgagaatg gaatccttcg cgtccaggaa 2985901 taaaattcgc ggtgtgatcc acggattttc ggccatttca tccagcgctt caatcagccg 2985961 gtcaaaaaat tcgcggccgc gcaaatccat cacgagcgca actttgctca ttttcgaatt 2986021 tgattccttc atcagctcta aaaacttcgg aagcaatgaa ggcggaagat tatcgacgca 2986081 gaaatagccg agatcttcaa agctttggat cgcgacagtt ttccccgctc ccgacattcc 2986141 agttataatg acaagctgaa tatcatgtga ttcactaaca ctcatctttc tcccccctga 2986201 cttgtctttc tatttgatgt gctgcgggtc taaacgataa ctgagcagct caaattccgg 2986261 tgtatacgta aatgtgccgt gcagcagccc ttgtcccttc atcataaaat caaggatatg 2986321 gccgtctcca ggggccatag gcaggttctg aatgtcattg acatcgtgcc actgcagttt 2986381 gccttcctct gattctgata cattttgtcc tgtatatgaa tcagcgacaa acgtaaacat 2986441 catccactcg gagacaatgt ggtcaccgtc tttaataata aaggtaaaaa cgccttttaa 2986501 ttgaggattt atgatataga taccagtctc ttctctgtac tctctgatga cggagtctct 2986561 gactgattct ccgctctcca tcttgcctcc cggcgcgacc caccatccgc gtctcggctt 2986621 ttgaagcaga agaactttgt catccgtctg aagcacacaa tttgtcactc tttgcaagta 2986681 cgtcacctaa ccttcgtcct gtcatcgtct ctttattata ccgcttcaag atgcctccca 2986741 caatgaagag acattgacaa tcttttcttc tattttacag catattcatt ccttaattca 2986801 gatgattttg ctgtaactgg aattctcttt tatttatgga caaaaaaagg acacggataa 2986861 ctggagaatc cgtgccaaaa aagtgtattc attataaaaa gggggtcaat tactttatta 2986921 atcataaccg aaaagcatta cacatgtgtt acagcggaat taaaacccag taacgtaatg 2986981 tgaaactcgt atgacagccc tttttatttt aaggttttca gcgtttcttg gagctcttcg 2987041 acataatgtt gtacgctttg tgccgcaatg cttccgtctc ctgtagccgt tacgatttgg 2987101 cgcagtgatt tttcgcggat gtctccggca gcgaaaatcc cttcaacctt agtttccatg 2987161 cggtcgtttg tttcgatata gccttcttca ttcgtaatgc ccaggttttc aaacggttta 2987221 gacagaggaa gcatgccgat gtaaatgaat acgccgtctg ttttgaattc actttcttca 2987281 ccggttaccg tatcgacaag cgttacgtta ccgactttgc cgttttcctc atgaatttcc 2987341 ttcacagttt tgttccatag gaagtcaact ttttcattat caaatgctct cgcttgaaga 2987401 atactttgag cacggagttt atcacgtctg tgaacaatcg ttacttttga agcgaaacga 2987461 gtcagatata cgccttcttc aaccgcggaa tctccgccgc caacaacgac aagttctttg 2987521 cctttaaaga aagcgccgtc acatactgca caataagata caccgcgtcc gcccaattct 2987581 ttttcgccag gcacgccgat ttttttatat tccgcacctg cagcaatgat gacagcacgg 2987641 gctttatatt cctttgaacc agctttgact actttgtact ctttgccgtc aatgacctct 2987701 ttaatatcgc cataagcgta ttcagcgccg aattttttcg cgtgttcaaa cattttgtta 2987761 gaaagctcag gcccaaggat actttcgaat ccaggatagt tttctacatc ttccgtattg 2987821 gccatttgtc cgccaggaat tcctctttca atcattaatg tcgataaatt cgctcttgat 2987881 gtgtatacag cggccgtcat cccagcaggg cccgcgccga ttataatcac gtcataaatt 2987941 ttttcttctg acacactatt cactccttaa accatctttt caagtttggg ctctttctta 2988001 taagataaga atccccatca aacgtattcc ttacccatat cctataaaat ctcatggtga 2988061 tacgctattt ttttgctcaa cacgattaaa tgtattcgaa aagggtatat gttaataaag 2988121 aaagagcctt ctgtttatag aaggcccttg tcatatttat tattgaacaa cacgtcttac 2988181 aacaccttta aatgctgctt tccagtaagg attgctcata gagtcaacag atacgccatg 2988241 agatgtattg tcgtttagga aagtaccgtt tcctaagtag attcctacgt gtccatttgt 2988301 tttgtaagtg tcaaagaaca caaggtctcc gcgtttcatt tcagacgcgc tgacagcttg 2988361 tcctctgcca actaacgtat cagttgttgt tccgcctaca ggtccaaggt taacacctgc 2988421 agaagcgtat gcccagcgta cgaatgatga gcagtcaaaa atacggttgt tgatatcaga 2988481 ctgagtgcgt ccgccgccaa acttgtacgg agattgtcct acaatgcttg aaccaacgct 2988541 gatcgcgcct tcaattccgc cagagttgct gataacagtg ccgcctgaat tgctgtttga 2988601 gccgctgctc ttcttagaag atgagccgtt tgacgaactg tttgatgaac cgttagaaga 2988661 attgtctgaa gaattgtctg aagaatcatc agatgagctt gcttttgatg attcagttgt 2988721 cgccgtttga ctgtcatctg tttgtgtttc atcagatgct ttttgtgctt cttcctgctt 2988781 tttgatcaaa gcagccgctg cttcttgttc ttttttgatg cgtgcttgtt cagcttcagt 2988841 atttgctttt tgatttgcaa gttcagacgc ctctgatttt aattcagaaa tcgctttagc 2988901 cgttttcttt tggcttgctt ttgcttcgtc gaaaagcttg tctttttcat taagctgttt 2988961 atcaaggtct ttttgcattg tttctaattt agccaaggca gcttgaactt ctttcagctt 2989021 gtcattcaaa tccgcttcag aatcttcgag cttcgcttta tcctgctctt gctgtttgat 2989081 taaatctttg tctgcgtcca caatagatga aaccgcagtc gcacgagaga taaagtcacc 2989141 aaagcttgtt gatcctaaaa gaacatctat gtatccttga gatccgccgc tttcctgtaa 2989201 agaacgaacg cgttttttca ggatttcatt gcgtttttcg atgcgtgctt cagtttcttt 2989261 aatctctttt ttcagttttt tgatttcttc ttttgtttta tcgttttctt cttttttatc 2989321 ttcaatcttg ttgcttgtat caagcgcctt atcgttaatg tctttcagtt ctttttcaat 2989381 ctttgattga ttttcctgaa gctcggttaa ttctttttcc ttcgcttcaa tgctggaagc 2989441 aacctcagat tgcttgcttt cgattttttg tttcttttca tctaatgttt ccgccgatgc 2989501 agttttactt gtaaatggga tcaaaaaact gcttgtcccg atgacggaag ccaaaccaag 2989561 tgtaattaaa ctctttctca ctttttatat cctccctttt actgtgaacc tgtcctcatt 2989621 tggaatcgta ttttgaacat caagtttcgt tcctcatact ctacgaggaa tgatggttgt 2989681 ttatggttaa ttattctgtg catctcttat tctggttgta tagcgtttat ttcacatcat 2989741 atgtaaaaaa cactaattcc ttatgtacga gaatcattat accatcaagt ttcgacaaat 2989801 tagcgataaa ttttattaca tttatgtttc aaacagatgt caagtcacac atcatttgtc 2989861 atttttctta agcgtgtaaa aaaactgtcg atattatttt cttaatataa tctatctaac 2989921 aaaaaaagag tcgattaaat aaatcaactc tttaaaattt actattctag aatatcatca 2989981 atatatttca tatatttcgt caaagttgcc ggagagatgc cgaatcgggc cgctgtgtct 2990041 tttttcgtgt cttgcttgcc atgggcttct ttccaaatat aacagatggc tgctgcccag 2990101 cctttctcat tcttcaacgg agcagctgca cgaatttgct ggatgacatg aaaaacccag 2990161 cagctcatga cttctgtttt catctcttct ttttcagctt gctctaatag tttgaccgtt 2990221 tgataagcga aaagtgcatc ctctgaaacg tcagcagccg cagaatctcc attcagaagc 2990281 agctttacaa aatgagtttc aaaaggagcg gtaattctct ttgagcgtat caccgcttca 2990341 agatgctctg tttctccctt tgtgctgctg atataatagg ctgcgagtcg ctgctccaca 2990401 gatgaaggaa gagcttccct ccgctcaatc caaggcgccg ggcggtcttc gccgggatat 2990461 tgcgactcga cttttctcca gatcgtctcg gcaaagtcgg tatgtcccgt aaaataagca 2990521 gagcaggaaa gccagtaaaa gaaggtgtcg tcaccctcaa agccggtttt atataatgat 2990581 ttgagccatt tatatccgat ctcgtagcgg ccgacaagcg ccaaagtagc acccaattta 2990641 taacgctgct ccaatagcat cggatagaca ttggagagct gatcactcaa ttccgccact 2990701 ttttcgtctt ctctttcata atagtagaaa acgagaagat tgcataaggc gtgaagattt 2990761 ccttcattat gagaaagcac ttcataagcg gtttgcttcg cttttacaac gtttcctgaa 2990821 tagaaatagg caagcgcgag attgttgtat gctgaccaaa gctccggata ttcagttgtg 2990881 atttcctcaa gcgccgcaac cgcttcagca agctggccgc tttccagcaa tgactttgcc 2990941 cgatcctgtt tcaccagcag ttcatcctga tcatacaacg aatcctcaat gccgtcgtct 2991001 cctaaatcga gcaaatcaag cagactatcg ttttcttcgg cgaattcacc atccgggtcc 2991061 gcatcagaat aagcggccgc ttctttataa gcttcctgga agagccccag atgggcaaag 2991121 ttattcgctt taaagtaatg gcactccggc atttcggcct ccagatttgc catgatatag 2991181 tcaagaagat cgttcgactc ttgatactgg cccatttccg aataaatgac cgcaagctgt 2991241 gaaagcatct ctgaatcctc cggctccaaa tgaaccgcgc gctgaatcag tttgcttgcc 2991301 cgttttagat tgcgctcttt atacgctttc aagcctttat gaaaaaaata ttgtccatct 2991361 tgaagcagct ggacaatttg tgcgtgattt ttatgttcag aagtgtgttt tcccacaact 2991421 accctccgtt ttatacaata ttaccgtcag tagtatacca taaatcgtaa gcccctcaat 2991481 agttcaaaag gaaggattgg gaaaatccct cctctttttt attggctgat tcgaccaaaa 2991541 tttacccggc tttgttttct aagtccgcat tcattttcag ctgctgttca gcaaaatccc 2991601 ggtaaaggcc atgggaagcc attaactcat ggtgtgttcc acgaccggta atttcccctt 2991661 tttcaacaaa caaaagctgg tccgcatcta caacggtaga taggcggtga gcgataacaa 2991721 tcgttgtgcg gccctccatc agcacctcca gcgcctgctg aactgatttt tcagattggc 2991781 tgtcgagact tgaggtagct tcatcgagca taagaatgct tgggttacgg agaagcgctc 2991841 tcgcaatcgc gattctttgc ctttgtccgc ctgacagcat aatgccgcgt tcgcccactt 2991901 ctgtatcaaa ctgattcggc agctccttta taaaattgag cgcatatgcc atctccgcgg 2991961 ctttttcgat ctcagcatcc gtcacatctc gttctaaccc gtagcaaata ttttctctga 2992021 ttgtcccgga cattaacggg ctttcctgtg atacataccc gatatgctcc ctccacgatt 2992081 caagcgagta agtatcgacc ggctcgtccc ccagccgaat ggtccctgca gtcggagaat 2992141 aaaagcgttc aagcagctta aacagcgtcg tttttccccc gccgctcgga ccgacgatcg 2992201 ctgtcacttt ccctgcttca atgacggcgc tgacctcttt taagatcagc tgatcaggct 2992261 tatatccaaa agacacgcga tcaagctgga taggcagatg tgcattttca atttgttttc 2992321 ctgtcactgt atcttcctct tcctctgcca aaatctcaat cattcgttct gttgcaccga 2992381 ttgatttttg cagctgtgtg aaaaacgttg taatctggcc catcggcata ataatttgaa 2992441 acaaatataa aataaaagcc acgagcgctc cggctgtgag ctcgcctgat gagacctgca 2992501 tgccgccata tccgatcact gcgacaagcg ctgccattaa cacgagtgaa ataagcgggc 2992561 cgacaagcga ttgaaccttg gcttcacgaa cgccaagctt aaataatgag gaaatcccca 2992621 tcttcccgcg cccatattcg acatcctccg catttgaagc cttaacaagt ctgatttccg 2992681 ggagaatttg attaagcagg cctgtaaaac gagccgtttc atcttgcgtt tcccgtgaaa 2992741 tggagaacat tttccgtcca atcggcacca aaataagagc ggccagcgga acgaccacta 2992801 acacaagcag tgtcagcttc cagttcataa taaacaagat tgtcaatgat ccaatgacag 2992861 aaatgatgcc tgtaataaat ccgctgatat gggttgtaat caattctttg accaccatcg 2992921 tatcgttcgt tacacggctg actgtttctc cggaagcatt tgtatcgaaa taagagacag 2992981 gcagcttaat taatttcttc cataataact cccgcagccc ggaaatgatt ttttgtccat 2993041 tatagttaag cgcataggtg gcataagcgc ttaaacccgc ctgaacgaaa aacaccagcg 2993101 cgatcaaacc gatttgcgtg cctgacagat ttgacataga aaaaccatcg acaagctgct 2993161 tcgttaataa tggaatgagc aggctgacca gcgtggttac tacactgagg gcaagcgcaa 2993221 aggcgagctt tccataagaa ggattggtcc gtcttactaa ggcaaaaaag ggtttcaatt 2993281 tacttttaga tttttgtttc ttggttggca tatattttcc tcctgtttca gcgttcagaa 2993341 aggtgaaaag tcatagcaaa aggatgattt ttactctttc tcaatcatat caatggagaa 2993401 agactttttc agtatatttt tgccgtgatc aaaataaaaa tctcccactc attgtttgaa 2993461 taggagattt ttgtgttaga catctttcac tggcttcttt tttctgtaag tcaatgttac 2993521 atcctgctgt cgcaggtctt ctattatcat tttgtaccga tcaacttttg cggtatgttc 2993581 ttcttttatc atctgaaggg cagcttttcg tttttcgcta ttagactcaa gctctttttt 2993641 tatttttttt acaatcaacc ctttttgccc tttgatttcc tcttttaatg aagactcaaa 2993701 tttctttgtc aggctgagaa agtcgttgat cggttgattg agggtgcccg ctttcccctt 2993761 catttcatct tgggtaagaa acatataggt cgttgataca atttctgttt cactttctga 2993821 aaataaggaa gtcactcttc atattcctcc taagactgaa aatcaaataa ctgagaaatc 2993881 atttcttctt tttcaaacag cttttcaata ctctcgcgga tatttttgat aaaatctctt 2993941 ttttctgttg tctgtttttt taattcagca acaattccat catttgcagg aagcgcacct 2994001 gtgtggaatg attcatgaac tgagattttc tccaatttat cgaatgtgtg gctgaaacca 2994061 gctgcaagcc ggaattgaag atcgaaggca taatgcgaag ggttttcttc catatgatga 2994121 atagccgtga tgatcgcctg ctttttgtct atgaagtctt catcgatttc ctgactgtaa 2994181 accttctggt acttagaaat cgcatcttcc atatcttcaa cgattttcat accgttttga 2994241 tagattctga cagcggatga gagattgact tgaatcgttt ctcccgagcc actcttccct 2994301 gtaaaataaa tatcggagcc tttatagctg aagccttttt cctttgacaa ggcgttgagc 2994361 atttgaacga tgctgtggcc gtcgacgata agttttagtg cgtcttttgt ttctgtgtcg 2994421 agtgttttca atgaggacag aattgatttt acatagtcca ctatttcacc aacgtctttt 2994481 aaagcttgca taaattggcc atgttttaga tggtctatga aatgttcgta ccgtgactct 2994541 atgcctcgca tactcgcatt aatattcgtt aattcttttt tgatgacttt cttttgcgtt 2994601 tcatcaatat aaccattttc agctaactga tctacgaccg gtccgctgtt tctcaacaag 2994661 gtatgaagaa aacctaaaaa cgacggcagt tcctctttta ttcggccata catttgctta 2994721 acatcatcaa aatgctcata taggacactt actttcttta aagcgccgtc tgtgtttttc 2994781 actttttcaa tcaggtctat gtctatcccg ctggctgcct ttataaaacc gttcaagccg 2994841 tctttttcat agtcatcctt atatttttga aggaattttt gaattgacct cacatcttcg 2994901 tcaggaaccc catccataat gtttcggatg ccttttacac ttgtatttgt atctgccatc 2994961 ttcacatcac cgaatgtaat aaaatcggcc ttgccgctga ctccatacag cgggtcatct 2995021 tttgagatgc gctgagtgat gtttgttgtt acgcctttgt cttcataata tttttggatt 2995081 tcttttttta acttttctgg cgggatggaa tctatatctt catatttata actaaatttc 2995141 ctaataacat atctatataa actttcatca gtttcaagta attgatcaat attgacttga 2995201 gctccattta ccccataaac ttcatcatat tctccatcaa tcaattgcac cataacttgg 2995261 ttattatttg caagtgaatg tcctaaggcg aatgttttta aatcctcaga gttacctgct 2995321 gctttctttg ctttgttagt aaactccttt gtagcctcat actgactatg atcaattcct 2995381 aaaaaaagac caaaaaagtt atatgaccaa tccttattat cggcactacc ttctgaaata 2995441 atctgaagct gatcaatatg ttttttctca tctattatat ggattgccgt tccatcgtaa 2995501 cctgattctc tggtcgaact ttgtatactt gtattctgat ttacaagttc attggaggtg 2995561 taaatttcaa ttttcatatt ctcaggaaga tcgtggtggg tttcctcttt ataaattctg 2995621 cgtatatctg cttcgaaatc cttcttagct ttcttaactt cactcgcaat agttgaggca 2995681 aacttttgtt tatagtcata ttctaaatca attaacctta actttacgtt ctcattctca 2995741 aatacatttt tatttcccat cttatttctc ctttttatct attaaaaagg tgatagaatt 2995801 aattaatttc tcaactttat ttttagcctt ttcttcatct aaggagcatg gttgattttc 2995861 atttttgcat ccaagggtaa aggcgtattc tactcctagg ttatcttcct ctgtagactt 2995921 aacatatcca aaataactgt atgaataatt atattttcta tcaatatcgt caaagatgtc 2995981 ttttttcttg gcagtgtaaa tatccgtttt ctttttgctg ctttttttgt attcgccttt 2996041 ataatcattt tttccactaa caatatctag cattgtctta ggttcattcg caaaactttc 2996101 ttctttgtaa tatgttacat ggccatcaaa cattacattg gtgtctttat cataactatt 2996161 aaatccaata ctttctttgt ttttcccggt taacgatgat cttcttgata gatactttcc 2996221 atcctccgga aacaacatcc taaacccttt cagcttagat tccagcaaat aatatcctgg 2996281 ttcctcttct tttgttgaca ccatgtactc tctcgttttc tcgtcctgaa acgcaggtac 2996341 ttgaggcaga tccttgggat ccatgtcttt tggttttacc gcttctgttt tattgtcatt 2996401 tgtgctgttt ttatcattgt cattcatact gcatcctcct gtcagggcaa gtaataagct 2996461 gaagcaaata aagatgatct ttttcattac gaacctccac gggttttgtg agaatagtat 2996521 tctattttta tatcaaaaat aattctattg acctggttaa gagatgatta tttcatcctt 2996581 tttcatgtta catcatggcg gaatttggat aaataggaaa tgagactcgg ttttgatctc 2996641 cttttattaa ctaatcatat ataacaccca atataaatct aaatacctat tacttttttc 2996701 acaaaacaaa aagagccgta tcatccggct ctttactctt caatctcaga atggcgtttt 2996761 ttcaatacgt caagcacatc atccagcggc agggattgtt ctctgagcag gacaagcagg 2996821 tgatacagca ggtctgccgc ttcccatttg agttcctcat gatcccggtt tttcgcggcg 2996881 atgatgactt cggatgcttc ttctccgact tttttcaaaa tcttatcgac gccttcacgg 2996941 aagaggtacg tggtgtaagc tccttcaggc atttccgctt ggcgttccgc gatcacccgc 2997001 tccagttcgt tcatgatgcc gaatcggtcc gcggcctgtt cttctgtttg ttcctttgta 2997061 aaacagctgt agctgccagt gtggcatgcc gggcctgacg gttctacgag tacgagcagc 2997121 gcgtcttgat cgcagtcata ccggatacct ttgacggctt gcgtgttccc tgaggtttct 2997181 cctttatgcc ataacgcttg gcgtgagcgg ctgtaaaacc atgtttcctt cgtttccagc 2997241 gttttttcgt acgattcctt gttcatatac gcaagtgtca gcacttcttt gcttgccgca 2997301 tcctgcacga tagcaggaat taatccgtcc tcgttaaaac gcagttcatc tgcctgtttc 2997361 atctcacatt caccccgtac tctttcaagt atgatttcac ttctttaatc gatgtttctt 2997421 tataatgaaa aattgaggcg gccagcgcgg cgtcggcttc tccttttgta aaagcctcaa 2997481 gcatatgctg tgcgtttccc gcgcctcccg aagcgataac agggacgggg acagcttcgg 2997541 aaacaagctt tgtcagcgtg tggtcgaaac cttttttctc accgtcggag tccatgcttg 2997601 tcagcaatat ttctcctgcc ccgcgtttga cgccttcttt tgcccacgcg gtgacctccc 2997661 aatctgtttt ctttctgccg ccgtgcgtgt agaccttata tgtgtcagat tctttgtcat 2997721 acttggcatc aatggcaagt acgatgcatt gagaaccgaa aaactcggct ccttctgtaa 2997781 tcagctcagg gcggagaaca gctgccgtgt tcaccgacac tttgtccgct ccggcacgca 2997841 gtatcgtttt catatcgctg agctgattga tgccgccgcc gactgtaaac ggaatggcaa 2997901 gcttcgcggc aacctgctcc acaacgtcaa ccatcgtctt tcgtccttcg tgcgaggcgg 2997961 agatatcaag aaaaacaagt tcatccgcac cttcccggtc gtacacttcg gcgagttcaa 2998021 ctgggtcacc ggcatccttc aattcgagaa attgaattcc tttgacaacg cgtccttctt 2998081 tgacatcaag gcatgggata atccgttttg tgatcatttg cgcttcaccc tttcaagcgc 2998141 ctcactcagc gtaaactgat tggtatacag cgcttttccg atgatcgctc cagagacgcc 2998201 gtccgcctca ttgcgggcga gagcttcgag atccgcgacg gagctgactc cgccggaagc 2998261 gatcaccgat ttccccgttt ccttagcaag ctcgaccgtg cttttaacat tggggcctga 2998321 cagcattcca tctgtcgcga tgtcagtaaa aataaagact tccgcacctt cattggctag 2998381 ctctttgccc agttcagttg ccttaagggt tgatgtttca agccatccct ctgttgaaac 2998441 aaaaccgttt ctcgcatcca gtccgattgc aattttctcg ccatattgtt tcagcatttt 2998501 tttgacaaac ggagggttag aaactgctga gcttcccagg atcacccgct cgactcctgc 2998561 tgataaatat tcatagacgt cattttcaga acggatccca ccgccgattt cgactttcag 2998621 gttcagcttt tgcgcaatct caatcacatg gcggtcattc actcttttcc cttctttggc 2998681 cccgtcgaga tcaacgagat ggatccattc ggcaccctct ttctcaaata actcagccat 2998741 gtcgtacggt gaatcgccat atatcgtttc cttattataa tccccttgaa caaggcgaac 2998801 acatttgccg tttctcatat caattgccgg atataatgta aaagcactca ttttttcacc 2998861 ttctgttctg ctgccatttt cgtaaattgg gttaaaatag acattccgac cgtgctgctt 2998921 ttttccggat gaaattgggc gccgaagacg tttctttttc cgactacagc aggcactcgt 2998981 acaccataat cggcgcttgc cagaagcgcg ttctcctcca tcccgtcaat gtaataggaa 2999041 tgaacgaagt aagcgtagcc ttgttctgtt ttagtcagca gcggagattc attatgaaaa 2999101 gaaagacgat tccagcccat atgcggaacc ttcagcttgt ttcctttttc atcttctgct 2999161 ttcagcctga ctgcttttcc ttttaacagc ccgagtcctg aagcggtgcc gttttcttcg 2999221 ctttcttcaa ataaaagctg catgccgagg cagatcccga gaagcagcct tccctctgag 2999281 accatatcgt gaatcaattg atcaagcttc gtgtagccca aattgtccat cgcgtctcca 2999341 aatgaaccga ctcccggcaa aatgaaagca tcagcttctt tcagctcctc cggcttttca 2999401 gaaacaaaat acggcacgcc gacacgttca agcgcctttg agacactgta taaattcccc 2999461 attccgtaat ctatcacgcc gatcatttac agcatccctt tcgttgacgg tattccttta 2999521 actcgcggat cgatcgttgt cgcttcatca agcgcacgtc ccagtgcttt aaaaacggct 2999581 tcaatcatgt ggtgggtatt tgttccataa tgaacgatga cgtgcaggtt cattcgagct 2999641 tcgagcgcca gcttccacaa aaattcatgt acaagctccg tatcgaaagt tccgacttta 2999701 gcagccggga aatcagcgcg catttctaag tgcggccggt tgcttaaatc aatcacaact 2999761 tgagcaagtg cctcatccat cggcacaaac gccgatccgt agcgtttgat tcctttttta 2999821 tcgcccaacg cttcgagcag cgcctgccct aagcagatgc cgatatcttc agtcgtgtgg 2999881 tgatcatcta tatcaacatc gccttttgcg ttaatggaaa gatcaaattg gccgtgtttc 2999941 gtgaataaat ccaacatatg tgtcataaac ggcacatctg ttttaatatc cgcttgtcct 3000001 ccgccgtcta ttgtaaatgc cagctcaata tctgtttcgt ttgttttcct gacgcgttcc 3000061 gcttttctca tttagaaatc ctccgttctc tcgcttcaat tgatctggca tgggcttcta 3000121 acccttccag tctggcaaaa gccgcgatgc tttcggcatg ttcttcaaag gctgattgac 3000181 tgtaagaaat aatgctcgat ttcttttgaa aatcagttac gtttaatgga cttgaaaatc 3000241 tggctgttcc gtttgtcgga agcacatggt tcggtccggc aaaataatca ccgacaggct 3000301 cagggctgta tctgcctaag aaaattgcac ccgcatgttt gatactgcca agcaaagctt 3000361 ccggagactg tgttatgatt tctaaatgct ctggcgcgag tgtattgaca gtctcaatcg 3000421 cttctaccat tgtttccgcc acatatatac aaccgtaatc tctcactgaa gcttccgcta 3000481 tttctcttcg cggcaaggtt tccagctgct tattcacctc ggctgaaacc gtctcggcca 3000541 gcgccatgga atctgtgaca aacacacatg agctaagctt atcgtgttcc gcctgtgaca 3000601 gcagatcggc tgcaatttcg ctcggaatcg ctgtttcatc agccagcacg acgatttcac 3000661 tcggtccggc aatcatatcg atatcgacat cgccgaacac ttctcgtttg gcaagcgcga 3000721 cataaatgtt gcccggaccc gtgattttat ccaccggctc aatggtttct gttccgtatg 3000781 ctaacgccgc aatcgcctga gcgccgccca ttttgtaaat gtcttttatg cccagctcgg 3000841 ctgcagcaac caaaactcca ggagacagca gaccgtcttt tcccggaggc gtgacgagaa 3000901 cgattctttc aacgcccgct acgagcgccg gaatcacatt catcaaaaca gatgaaggat 3000961 atgcggccgt tccccccggc acatatacac cggcggaatc cagcgccgtc actttctgcc 3001021 ccagcattgt gccgtccttt ctgtgataaa accaggagga ttgcagctgt ctttcgtgat 3001081 attccctaat attttcgatt gcctgcctaa tcacctgaag aagacgtgaa tccagtgagg 3001141 tgtatgcctc ctcaaattct tcttttgtga ccagcgggct gtctatttcg atgcagtcaa 3001201 atttcgccgt gtagctgcga accgcctgat caccgtttgc tttaacatct tcaataatgg 3001261 accggaccgt ctttctttgc tcttccgttc cggcatcgat ggaacgcttg agagaaagcc 3001321 gttccgctcc gctgatggtt ttgatcttca ttttgccgtc tctccttcca caacgagaga 3001381 taggcgggat gccatttcgt caatcacatc gtctttcatg cgatagctta ccgggttgac 3001441 aataaagcga gaggtaatgt cacaaatgtg ctccgtttca acaagcccat tttctttcag 3001501 cgtctgtcct gtggaaacaa tgtccactat ccgatctgca agcccaatga gcggagccag 3001561 ttcaattgaa ccgttgagct taataatctc gacttgttct ccctgctctc tgaaataact 3001621 ggaagccaca ttcggatact ttgtcgcgat tcttggcgct actccgctcc agtctgtatt 3001681 cggaagtccg gcgacagcta agtggcattt gctgatgttt aaatccagta cctcatacac 3001741 atcgcgttcc tcctccagca tgacatcctt gcccgcaatt ccgacgtctg ccacgccatg 3001801 ctccacatac gtggttacgt ccatcggctt cgctaatata aaccgaagat tttcctccgg 3001861 cacatcgatg atcagttttc tcgaatcttc aaactcctca gggagcctgt agcctgcctg 3001921 cctcagcagc cctgccgctt cttcaaatat ccggcccttt ggcatcgcca ttgtgagtaa 3001981 cttacccatt ttgctcttcc tttctggcac cgataaaata agtgacgttt gcaaaagatt 3002041 ttgtcatctg gtcgatattt tctattcccg ataaatcttg aagaaccact ttgttccctt 3002101 tcatgcgttc ttcattcgca taagcgatgg cttgcgcccg ctgctctttg ctgaaaataa 3002161 cagcgtctat ttcacaaggt tcgtccttca tatgaagggc ttcaatcagc cggtcgatcc 3002221 gaagcccgaa gcctgttgcc ggtgcaggtg aatcaaaatg gcccagcagc ttgttgtaac 3002281 ggccgccgct tccaatgaca aaaccgacat tctcggcgta cacttcaaat aaaatccctg 3002341 tgtaatagct catgtggctg accatattca gatccaggcg gacattttcc gtacatccgt 3002401 aatcctcaag aatgtcccac agcgccttca gctcatcaac cacgcttttt ccttgcgcag 3002461 aatcgacgat ttcctcggca cgtccgcata cttctatacc gccccgcagt tcaaggagct 3002521 caagcagcct gcttttatca atggaggaaa gcgggagaga cttgacatgc tctctgtagc 3002581 cgacgtagtt cttttcatat aagaacctcc gcagcacatc agctcgttca acgtttccga 3002641 gcacctcaac aaacaaagca tccgcaatgc cggcatggcc aattgcaatt ttaaaggatg 3002701 ccagcccagc gttttttaat gccccgacga ctaaagcaat gacctccgca tccgcgctcg 3002761 tcgtgccgtc accgattaac tccactccga cctgctcgaa ctcagccgga cgtccgcctt 3002821 cacgctcctg agccctgaat acatttgccg catagccgac tcttagcgga tgaccgtgtt 3002881 tcagaagctt cgatgccgcc acccttgcaa tcggccccgt catatccggg cgaagcacca 3002941 atgtcttgcc gtcctgatca agtagcttaa acagctgctg ctcttcaatt gctgactgga 3003001 cgccaacggt atcgtaaaac tccagtgtcg gcgtttccat aaattgatat ccccatttat 3003061 caatcaaatc ggttaacgat cgtctcacct tttttttcgt ttcgtataaa ccgggcagtg 3003121 tatctctcat gccgtgcggt ttttcaaaca taaacatcaa cccgagcacc tccgctgtta 3003181 tcttatgaag gaaaattccg aatcctttag ttcgctaata tgataatatg ttagcagatg 3003241 aaagaatgaa aatcaacgct taacttcagt aaggatattt ttagttcaaa tatccttctc 3003301 ctcattatga aaaaatcatg aataatgtat taaaggtacg taatatctca aattctttat 3003361 gtttggcatg ctataataca aatcaaatag agaacaagga gataaagatg aaaacactgc 3003421 gaactctatg tgtcctgatg attctttcag gcgttatttt tttcggactt aaaatagatg 3003481 caaaagatat agatattcct tttttgaaca gccttaaaaa agtggtttct gatagcgata 3003541 cagactcagc tgcgaatagc aaaaaggagc tgaagggaag cgcaaaaccg ctggatgtca 3003601 tcctttacaa tcaaatggac gcaccccggc tctataacgg ctgtgaagta acaagccttg 3003661 cgatggtgct gaattatgcg ggatacgacg tgacaaaaaa taccctggca aatcaggttg 3003721 ccacagtgcc tttgacatac agcagcggat taaagggtga tccgaatgac ggatttgtcg 3003781 gggatatggc gaatggccct ggtctcggtg tctaccatcg accgatctat cagctggcga 3003841 aaacctatgc gggagacaaa gtgtctgatc tgactggaaa aagtatttcc gctgtttatc 3003901 agcagcttga aaaaggcaat ccagtttggg ttattacgac agccaacttt acgccagttg 3003961 acaacatgca gacatggaaa acgccaaacg gaacgataga aattacgtac agcgaacaca 3004021 gcgtcgccgt tacgggatat gatgataaat atgtgtatct caatgatccg tatggctata 3004081 aaaacagaaa aaccgataga acaagctttg aaaaagcgtg gaaacaaatg ggcagccagg 3004141 ccgtggttat tcaaaagtaa acacctgaag cctcactatg ctctattctg agcaaatacg 3004201 acaatattca tgctttttgt atcaatcggt aagatcgatt cattttccat ttttcaccca 3004261 aaattgtctt tactttcagg ctgtctgttt ttatgattaa agcagattca gccttgcccc 3004321 gatctatgcg agagaagccg gtgcaagtcg ctgacgcttc tcttgcaaaa aatgaaagat 3004381 atccggggag gatttatcat tgaaaaaaat cgtgtctatc ctatttatgt tcggtttggt 3004441 tatgggtttc agccagtttc agccatcaac cgtttttgca gctgacaaag tggtgcacga 3004501 aacaattatc gtaccaaaaa atacaacata tgacgggaaa ggacagcggt ttgtggcagg 3004561 gaaagaatta ggtgacggaa gccagtcaga aaaccaagac cctgtttttc gtgtggagga 3004621 tggagcaacc ctgaaaaatg tggtgcttgg tgcacctgca gctgatggcg tgcacactta 3004681 tggaaacgtt aacattcaga atgtgaaatg ggaagatgtt ggtgaggatg cgttaacggt 3004741 gaagaaggaa ggaaaagtga cgatcgacgg cggttctgct caaaaagcgt cagataagat 3004801 attccaaatc aataaagcca gtaccttcac agtgaaaaat ttcacggcgg ataatggcgg 3004861 gaagttcatt agacagcttg gtggttcaac cttccacgtt gatgtgatca tcgacaagtg 3004921 caccatcaca aacatgaagg aagcgatatt ccggacggac agcaaaacaa gcacggtcag 3004981 aatgacaaat acacgctact ctaatgtcgg tcaaaaatgg attggtgttc agcatattta 3005041 cgaaaacaac aacactcaat tttaacaaaa aaagtccgct gatgttattc agcggacttt 3005101 ttcaatcttt cttgcatttc ttccttcgta tagatgatcc tcatcggatt tccgccgaca 3005161 aatgccccgt caggcacatc cttatggaca agcgttccgg cggacacaac tgcgccatct 3005221 cctattttca ccccgggcag aatggtcgtg ttggcaccaa tcatcacttc gtccccgatc 3005281 agaactttgc cgatccggta ttcgtgaatc aaatactcat gggccagaat ggtcgtattg 3005341 tacccgatga ttgtatttgt tccgactgag atcttttccg gaaacatgat atctggcatc 3005401 accatgaggg caaaggatgt ctgttttcca accttcatcc gcagaaatgt gcggtacagc 3005461 cagtttttca tccctataaa cggcgtatat ctcgcaattt gaatgacaat gaaatttttg 3005521 acgaccttta aaaaaggtac cgtttgatag acatgccaca gtgagttggc ccccgagacc 3005581 ggatgacgat ctgtttttct cacagattac ttcactccaa cgatttgtaa tagatcactc 3005641 attttctcaa gcataaaatc cggctcatgc ttcgccagca tttccggccc tttaatcgtc 3005701 catgcgactc ctgccgtttt tgtaccggcg tttttccctg ccagcacatc atggtaatta 3005761 tcaccgacca taatggcttc cgccggctcg cttcctagct gtttcagcgc taacagcaca 3005821 ggctcgggat caggctttgc attcgtcaca tcatcaaggg tgacaactgt ttcaaagaat 3005881 tcgccgattc ccgtgagctt gaggcccata ttgacagtat ctcttaattt tgttgtcaca 3005941 attcctaatg taaagccggc tttttttaat gcatccaggg tctcatatac cgtttcatat 3006001 tcagtgacga gtgaatcatg catgtcatga ttgtacgctc tgtacatagc gatcatatcc 3006061 tcgcatttat cagggtccat cgaagagaac gtatcaaaaa gagacggccc gataaatgca 3006121 aggacatctt ctcgtttata cttgctcgga taataatgct ccagtgtatg caaaaaggac 3006181 gcgataatta attcattcgt attaataagc gttccgtcta aatcaaacag aatcgtcgtt 3006241 acttgtttgt cactcatatt gcttcctttc caaccgctga gggtttccat tttttccacg 3006301 tgtgcgcaat agccattgtc agcagaactg ctgtggtgac acgaatcaaa agaagcggcc 3006361 agaccggtat gccaagcgga ataaagacaa gtgtatcttc cacgaccgcg tggcaggcaa 3006421 cgagaaatat aaatgccaat gtcatgtccc gcttgctcac gccgtcatcc tcgacagctt 3006481 tgatcatgac acccgctccg taggccagac caatcgtcag tcccgtcacc atcgtcatag 3006541 acgtattttt attcatgcca agcagctgcg taaacggcga cagccacctg gaaaaccgat 3006601 aaagccagcc taaatctctt aaaaactgga tgataatcat cagcgggatc actattgccg 3006661 ccagctgcaa aacaccaagt ccggctttcg ttaatgcttc tgccaacatt cctagccagc 3006721 tgtctggcgc cgcgctcttc gcagcgataa aaccgtactg cgccgtttcc tttccgccat 3006781 gccaaatgag gttgatgacg atggctgaca cagcggccaa accgatgcgc acggccaata 3006841 tgacgccaat tctgatacca acctttgcgg caactgtcga ttcgataatc aagttatgac 3006901 agaaagaaag cataacagct aaaataaaga cttctttcac agataaatcc aatgttaaaa 3006961 tcccggcaat tcccgcatac agattcagca tatttcccag tacaagcgga atggccgctt 3007021 caccagaaag cccgaagaga cccattaccg gtgtgatcag ccgtacaagc caatccatga 3007081 caggggtatg ctggagcaaa gtgaccaata gcgttaccgg gaaaatcact ttacccagcg 3007141 tccatgttgt ttgaaaacct gctgcaagac cggccagaaa gatcttcttc atccctcatc 3007201 cccctttgtt gacgtctact ccgcgtaccg ctccttcgag tatcccttga cgcgtctgaa 3007261 gatgatggct gccacagcca aaacaatcaa tacgattgaa atcacctgag cgatgcgaag 3007321 tgaatcagtc agcattaagc tgtcagtccg cattccttca ataaagtatc ttccgattga 3007381 ataccaaatg atatagatca agaacatctc gcctctacgc aaattcgctc tgcgcagcag 3007441 cagtaaaaca atgacgccga caaagctcca tagtgattca tataaaaaag taggatgata 3007501 atattgccca ttgatataca tttgattgat gataaattca ggcaggtgca ggttttctaa 3007561 aaaggctctg ctgacagcct cgccgtgcgc ttcctgattc atgaagttcc cccagcggcc 3007621 gatcgcctgg ccgagcaaaa tgctgggcgc ggcaatatcc gcaagcttcc agaacgaaag 3007681 gtttttcact ctcgaaaaca cataacccgt taaaatggcg ccgattaatc cgccatgaat 3007741 ggcaatgccg cccttccaaa tcttaatgat ttctcccgga tgtgccgcat aatagtccca 3007801 ttcaaaggca acataataaa ttcgtgcgca aataatcgca attggaatgg caaacaggac 3007861 aagatcaata aacgtatctt tctgcagccc ccgtttttca ctttccctca tcgctatcca 3007921 cagcccgagc aaagcgccga gaccgataat gattccgtac cagtggacgg ctaacggccc 3007981 cagctgaaat gctatcggat tgagtggttc tatcgcttca ttcatttaac gccaactcct 3008041 attcttcttg ttcaccgtct tcaatgacgt ccgccagctt gttggtaaat tgttcagcgg 3008101 cattcagccc catccgcttc aatctgaagt tcattgctgc cacttcgatg atgactgcaa 3008161 gatttcggcc tgggcggacg ggaatcgtca gttttgtaat ttctgtatca atgattttca 3008221 tggtctcttc ctcaagtccg agccggtcgt attgcttgcc ctgctcccag agttcaagat 3008281 tcatgacaat cgtgattcgt ttattgcttc tgaccgcgcc agcgccaaat agcgtcatca 3008341 cattgataat gccaaggccc ctgatctcaa gaaggtgctc aattaattcc ggagcgtttc 3008401 ccacaagagt atcctgatcc tcctgccgta tttcaacgca atcatcggca acaaggcgat 3008461 gccctctttt cacaagctct agcgctgttt cgctttttcc gacgccgctt tttcctgtga 3008521 tcagcacgcc gacaccatat atatcgacaa gaacgccatg aattgctgtg gtaggcgcca 3008581 gcctgctctc aaggaagttg gttaaacggc ttgacagtct tgtcgttttc agcggcgatc 3008641 tgaggacagg caccccattt ttctcggagg cgtcaatcag ctcctgcggg atgggcatat 3008701 ctctagaaag aataatagct ggtgttacat cagtgcacag agaatccatt cgctgctttt 3008761 tctcctcttc aggaagctgt tcaaagaaag aaagctctgt ttttccgaga agctgcacgc 3008821 gctccctcgg gtaatatgta aaatatccgg caatttcaat acctggtctt gataggtcac 3008881 tcattgtaat cgggcggtta attccttctt ctccgctgat taattccaaa ttgaactgtt 3008941 ccattacgtc ttttgtgcga acctttgcca cgatatgttc ctcctgttcc gggctgcccc 3009001 gagcttgctc acaatacttt cattttatca ctttcgggct tgaacctaaa acagatttta 3009061 taaaaggggg gaaaacacct cagctggtct agatcactag tctgaaaaag agtaaaataa 3009121 aggtattcaa attccagaaa ggcggatcat ctatggcaga gagtcttctt atcaaagaca 3009181 ttgcgatcgt gacagaaaat gaagtaatca aaaacggcta tgtcggaatc aatgacggaa 3009241 aaatcagcac agtttcaaca gaacggccca aggagccata ttcaaaagag attcaagcac 3009301 ctgcggattc cgttttgctt cccggcatga ttgacattca tatccacggc ggctatggcg 3009361 cagatacaat ggatgctagc ttttccacgc tcgacatcat gtcgtcaaga ctgcccgaag 3009421 aaggcacgac gagcttttta gccacaacga ttacccaaga gcatgggaac atttctcaag 3009481 ctttggtgaa cgcaagagag tggaaagcgg ctgaagagtc ctctttatta ggtgcagaac 3009541 tgctcggcat tcatttagag ggcccctttg tttcgcctaa aagagccgga gcgcagccaa 3009601 aggagtggat taggccttcg gatgttgagc ttttcaaaaa gtggcagcag gaggcgggcg 3009661 gactgatcaa aattgttaca cttgcgccgg aggaggatca gcattttgaa ctgatccgcc 3009721 atttgaaaga cgaatcgatt atcgcatcca tggggcacac ggatgccgat tccgcattgc 3009781 tgtcggatgc cgcaaaagca ggggcgagcc atatgactca tctgtacaac gcgatgagcc 3009841 cgtttcatca ccgagagccc ggagtgatcg gaacggcgct ggcccatgat gggtttgtga 3009901 cagagcttat cgccgatggc attcactccc atcctttagc tgcaaagctt gcttttttgg 3009961 cgaaaggcag cagcaagctc attttaatta ccgattccat gagggcaaaa ggactgaaag 3010021 acggcgtata tgagttcggc ggccaaagtg tgacggtaag aggacgaaca gcacttcttt 3010081 cagacggaac ccttgccggt tcgatcctca aaatgaacga aggcgcacgg catatgcgtg 3010141 agtttacaaa ttgctcttgg acggatatag ctaatataac ttctgaaaac gcggccaaac 3010201 agctgggcat ctttgaccga aaaggcagtg tgactgtggg aaaagatgca gatttggtga 3010261 ttgtcagcag tgattgcgag gtgattctca ccatttgccg cggaaacatt gcatttatat 3010321 ccaaggaggc tgaccagata tgaaagtaat ggaatgtcaa acgtatgaag agctaagcca 3010381 aatagcagcc agaataacgg cagatacaat caaagaaaaa cctgatgctg ttctcggttt 3010441 agcgacgggc ggcacaccgg aaggcacgta tcgccagctg atccgcctgc accaaactga 3010501 gaatctctca tttcaaaaca tcactacagt taatttggat gagtacgccg gactttcaag 3010561 cgatgacccg aacagctatc acttctatat gaacgaccgt ttttttcagc atatcgacag 3010621 caagcctagc cggcatttta ttccgaatgg aaatgcagac gatttggagg ccgaatgcag 3010681 acggtatgaa cagctagtcg attccctcgg cgacactgac attcagcttc tcggcatcgg 3010741 ccgaaacgga cacatcggct ttaacgaacc gggaacgtct ttcaagtcgc gaactcatgt 3010801 tgtgacatta aatgagcaaa cccgccaagc gaatgccaga tattttccct ccatagacag 3010861 cgtgccgaaa aaagcactga caatgggaat tcaaacgata ctctcaagca agcgcattct 3010921 gctgcttatt tctggaaaaa gcaaagcgga agctgttcgt aagctgttag aaggaaacat 3010981 aagcgaagat tttcccgcat ctgctttgca cctgcattcc gatgttacgg ttttgattga 3011041 tcgtgaagcc gcgtcattaa gaccttgaaa ggaacatgct gacttatgaa tatcaataaa 3011101 caatcgccta ttccgattta ctatcagatt atggagcaat taaaaaccca aattaagaac 3011161 ggagagctgc agccggatat gcctcttcct tctgagcgcg aatatgccga acaattcggg 3011221 atcagccgga tgacagttcg ccaggcgctt tctaatttag ttaatgaagg cttgctctat 3011281 cgcctgaaag ggcggggcac ctttgtcagc aagccaaaaa tggaacaagc acttcaaggg 3011341 ctgacaagct ttaccgagga tatgaaaagc cgcgggatga caccgggcag caggctcatt 3011401 gattatcagc ttattgattc aactgaggag ctcgcggcta tattaggctg cgggcacccc 3011461 tcctctatcc ataaaatcac tcgggtgcgg ctggcaaatg atattccgat ggcgattgag 3011521 tcctcacata ttccgtttga gcttgcgggt gaattgaacg aatcgcattt tcagtcgtcg 3011581 atctatgatc atattgaaag gtacaacagc ataccgattt cccgtgcaaa acaggagctt 3011641 gagccaagcg ctgccaccac ggaagaagcg aatattcttg gtattcaaaa gggagcgcct 3011701 gtcctattaa ttaaacgaac aacatatctg cagaacggaa ctgcttttga gcatgcaaaa 3011761 tccgtataca gaggcgaccg ttatacattt gtccactata tggatcgtct ttcataaaaa 3011821 aagcctccaa ccctttttaa ggattggaga catggcgaaa atcaaactgg tctggtgccg 3011881 gacgatatgt ttcttttttc gtcttgaact tccagatcgg tgatttcgtt ttgccgttaa 3011941 aactgtcttc cactataatg taccaataat aaacagactg cggttcaaga tgatcccagc 3012001 ggaattcagc tgtgtccccg ctcttcactt gctcccgttt tccgagctct tcattggtat 3012061 atacgttaca ttcaaaataa tcggtttcca cctttttgat tcttggcttc aaatcaagcg 3012121 aaagggaaaa ttcatccttg ttgccatagg tatccgtatc atagtagttc ttatccttta 3012181 catacggaga gtacgtcgat acgtgcacca tgtcattggc ttggtcaaat tgaagcaaac 3012241 gcaaataccc ttggccgcct tctggcccgc cctgataatc ggccagcatt tgatgcacaa 3012301 gacgatccgg tttcccatca ccatcatcat ccagctcatc tgtttttctc atcgcactat 3012361 gataatgccc gctcaacacc atcacgacat tcgggttcgg ctttacgatt tctttgaata 3012421 ttttctctcc gattgggctt ctgtttccgc tgaccagcaa atactcatga aaagctaaaa 3012481 tggccatccg gtcaggatgc ttcttcagca cctgattcat ccacgcgatg tcttcatccg 3012541 taatgcccca tcccatgtac agcatgatat aatcattgcc gttgctagaa atcaggtcat 3012601 aatgtccgcg gttattttta taggaaccgc cataatgaaa ttttttatca aaacgatcgc 3012661 tgccaaaata tttgccaaac gccctgtagg agccgtcctt atgtccgaca tcgtgattgc 3012721 cggccagcac gccgtaagga attccgctct tatccagaac ggacattgac cgatcagcgt 3012781 ttttccactg tctgatatcg gcggaatcat ctacaatatc acccgtgtgg aacacatatt 3012841 tgatattgag ctgcttttga ttatctttta tccattcggt ctgtttatca aaaatatgcg 3012901 gatagctttc ggcgtaatac tgtgtatcag acatccagac aaatgtgtac atatccttcg 3012961 caggaggaat ttcatcctgt acaatcacat tcattttcga ctcccgtaca aaatcggcgg 3013021 caatcacaga cgctttcagc gtaaacggtt tgtcatcctt cgcgacgaag ctgtcaacag 3013081 gctgccattc gtttgtccga taattccaag catacatcgt cacctttctc cccggcaaag 3013141 aactgccctt ccagactgat tctgccagat cattctcatc aattgatgga tcaaccgtca 3013201 cttcaaagcg atgataaggg aaaagctctt tgttttctgt cgatactgtt tttccatcag 3013261 cagctgatac ccgctccaat tctttattcg taaatggggt ctccctttcc ggcacaaagc 3013321 ttttcggcgg ttcagtcagt gacgcgtgct taaatatttt cacatgattg cgcgctgtat 3013381 attgaaatcc cctataaaaa ccaacatcca tggcatcatt cgtcggatct ttcacccgta 3013441 cagaaagctt ggccttatgc gtgtcggctt cgctgtctat aacctccggc tggtccggat 3013501 gctctcgttc ggttttaaat atcctctcaa tcactgtttt attgcccgcg agatccgttg 3013561 ctgtcacttt tagagaatgt tttcccggca aaaggtcaga agatgacgta tgatatggga 3013621 gtgtaatgct ttctccatct aacgacgcct ccgcttcctc aattctgctc catttatcat 3013681 acatatccgc ctgcaggata aggtttcctt tatacgtttg cccctcggtg atattcggct 3013741 caatgtgagg tcctgaatta tctacccgta caaccaggct gacattttcc ttcccgtcgc 3013801 ttgcttgaat atggtgagcg ccttcagaaa gctttgatgt atcccactcc agcagctgtg 3013861 atgtaaatag tccgtcaggc agattgaact gaaattgcca gcttttattc gagcgctgat 3013921 tatcgccaat aaagagttcc ttctcaggag acaccctctg atctctgatc accgttccat 3013981 ccgataacac caatcgggcg tttttgacta agaagtcatc acggttttca gccgtatcaa 3014041 acggagacac cttcgaacct gaacgtatcg taatacgctg cagctgcttc cctttccgaa 3014101 gcagtgtctc tggcaatgga acagaatagg tgcggtattt atttgttgta tcatcgaaca 3014161 ccttcagcac tttgccttcc atcgttaccg cgtttttaaa ataaaggttc gttttcctcg 3014221 tatcgaatgc aaaatatact tctttttcca tcgcgggctc tgtcacttgt tttttcccgt 3014281 caatccatag cttaatgctg tcagctcgcc cttctgtcgt ggctttgaga aattgagttc 3014341 ccgacagcgt gtctctgttt tcaatattca tccgcagacc gtgcgccttg cttgtttgtt 3014401 taatatcaat cattttgacc ggcgttctcg cttcattgat cccgtccccg gccgccacat 3014461 aatactctag ctgatccttc ccgatcaatt caggcgaata cacaatataa tggaagagat 3014521 tatcgttgcg gtctttttca gcaagaattc gcttaaacgg tttgttctca tccgtccggt 3014581 agtaaaaggc cactgttttc actaggcttc ggtcccgtat gtcagcccgc agctcaatgc 3014641 tttcagcagg gcggacaggc ttgcggtcag tcaaatcctc aatgaccggc ttttctttat 3014701 cgagcttgat tttccgtttc tggtcgggca cctgtgcctg taatacggtt ccgggagacg 3014761 gattcttttc cccgattgaa atgttcagaa gttctgctgt tccgttcagt ggatacttat 3014821 aaagcactga tgacagccgg cgcagcgcat gtttccgata atgcgcaacc gaaatgtcct 3014881 ttcctgtatt cgttgatatc acaacggccc gcggcctcgt attggccata ccctctgtct 3014941 cgtctatcac cgcaagattt tttccttctt ttagttgtgt ctgataataa cgattgaaat 3015001 ccgctgacgt caattctgga tgcccggcag gcttcagcca gacgacaaac gtttcgccgg 3015061 atggtatcaa gatcctttca tcaggtctcc aaatcagatc ggagtcaggc ccttcttttg 3015121 ggtagcggta acggatatgg tagtctttaa aatcaatcgt tctgtcagtc gtattaaaaa 3015181 tctcaataaa ttcataaccg tctgcgcgtc ctatattctt cgtatcaacc gccagctctg 3015241 tgatcagaag ctccggaata tgggcaaggt cagcctggta tccttcaagc ttcagtttct 3015301 tcgtctccga ctcaacccgc tgcttcccat tcgacatcac aatgtaatac tcaagctcgc 3015361 tgttccaaat caaacgtttc ggaatttgtg ccaaaaactt gcggaccgct ccgggggtcg 3015421 ggtccatcgg caccattttg tagcccagct cattactttg tttataaaaa agaaaggcgg 3015481 aaaatgcttg atacgaatta tcgcgaactt gagcctcaat cattagattg cttctcattt 3015541 cagctttcac atcaatttga ggaggatttt caagcaaggg tatgtaatga ggcgtttgaa 3015601 atagttcctg ctgtacaaca ggaaaagctt tcgattcatg atggccgcca gacaaaacgg 3015661 aaagaaaaga cagtaatata gaagcaataa ccgtgtattt cctcatcaaa gcacctccct 3015721 tttcatgtat tttgcgtctg aacagggaag cttatgagtt catttttgtg cataaagaac 3015781 aaaaaaacgt ctgtctcttg aaaattccac tattacccag taaactaagg atagttaacc 3015841 agttaacaat taaatcagag aggcaaattg atggacaaca gcattcatga tgaattattt 3015901 caagctatac aacaattcgc attaaaaagg gataaacgcg tctggcaaaa ggtgcagata 3015961 ccatccattg gcatatcctc acaacatcac gatcacctca aaaaagactg gactttgacc 3016021 cagcttcaca ttgtttcctg catacatacc agccaaaatg tgaacaacag cttcttagca 3016081 tcccgtttac acatctcaaa agccgctgtt tcaaaagcgg ttcatgcttt gttgaaacac 3016141 aatatcatta cagtgacaaa aaagcctggc aacaaaaaag aaatttttta tacgctaact 3016201 gatagcggca gaaaattggc ggcattacat gaacagcttc atgagaaagc aaaggagcaa 3016261 tataaacagc ttttcaatga attttcaatt gatgatttaa aaacagtgac tgcgtttttc 3016321 aacttgtgga tcaaatatat gtaaaaagag tctcacccgc atgggagaga cctttggaat 3016381 tctattatgc cccgtcaaac gcaacgagaa gtgaaacagg tccgcgtgta tacagaccgg 3016441 actcagcata acaaaaatct tcctctaatc tgatattccg catcttatcc agcacaatat 3016501 tagctacaat ttcgatttcg tttttggcaa aagctgctcc tacacagtta tgaatgccgg 3016561 atccgaaagc gagatgccgg gcggcgccgc taaaagcgct cttgatacca agatcttccc 3016621 gatgaatatt aaacacgtca ggctgttcaa atgcttcagg gtcccggtta gccgcaccga 3016681 tcatacaaaa aacaatcgta tcttttttga tttccatacc gccgaccact gtatcttggg 3016741 acagctgccg cggaatcagc tgaaccggcg gtttataacg caatgtctcc gcaatggctc 3016801 tcggaactaa cgaacggtca gccaaaacat cattcatctg ctcaggattg ttgagcaaat 3016861 ggtagatcat cagtgccagc gtcttatcag ccggttccgt tgcggctaac agcacattaa 3016921 gaatcagtgc gagtatatcc ttgtccgaca gcgccatgcc ttcatattca gaagtacata 3016981 ggatcgaaat taaatctgat cccggattga cgcgacgttc tttaatgacc ggcatcaagt 3017041 attgggaaag ctgttcgctg caccataacg aatgtgcccg cgcttcagga gattgagaga 3017101 tactcgtgat aaaatcggca actccgctgt gccactcaga gattttttca tggtctcttt 3017161 tatccagccc gagcatgtcc atcgtgacgc acaccgcaaa cgtctttcca aaatcattga 3017221 cgagatcact tttccctctt tcaagataag gcgctaacaa gttttctgca ttttgtttaa 3017281 tcaatggaga cagatgatcc agtgcgtcac cgataaagct tctcactaca attcttcttt 3017341 tggcagagtg ttcttttcca tgcatttggg ccagcacagg gcctcgcatg actggttcgg 3017401 cacgctcaac aagtgatttc gtcgtgaaga tatccggatg ctgaaggata tagcggacat 3017461 catgatagcg gctgataaaa taactgtcta tcgactcttc ataatgaacc ggatcttcct 3017521 cccgcagttg tgaaaaataa gcatatggat tgttttgaaa ttgatcagaa agcacactaa 3017581 acaatttaat cgattggctc atgttttact ccccctatca tccttcagat gtgatccgtt 3017641 tctcagaaag catctgcgcc atttcctgta caatgagata cccttgattc ggccgcatac 3017701 aaatagaaaa ttcatggtta ctgatcttct cacccagctt ccacggacga tgataagcaa 3017761 ggagtgtctc ttccacctct aaaatatccg gagctccgat aaaaaacggc agctcagcta 3017821 tgacatattc cacagccaaa ttcagcatat cctcactgac ttcttccatc atcaaactga 3017881 cgccccgcgc acgcccgatt atcgcttcac gagacatgtc caaacaagca tgtcgaaaat 3017941 gaggctgctc aaaaaatgca tgttcaactt cttgtctcaa cagctggtag gctttgttat 3018001 ctataaaatc agaaaatgta tgaatcgcct tcggatcccc gccatgagcc acaagggctc 3018061 tttctgcaaa tctcctgttt cgtgatacct ctttccttac ttttcgttca gcctttcctc 3018121 tcggagttcc aagcgcttct agaagattag ccgcctcatg ccctgcaagt aaaactgaaa 3018181 cgcttttaaa ttgagctttc gcccatccaa ttaatctgta aatataatcc tctgaaaacc 3018241 tgctgttaaa tgggctgatc cccaccaaaa catgcctgcg ccgttcaaat atttctctgc 3018301 agttttctgt taatgcctca gcaataaaat gcacagacct tctttccgtt accattccgg 3018361 tcatctcatt cacccctaaa acttatcccg ctttaagtca tcaccctcaa atacaagatg 3018421 gaatagctag aacaactgaa caagacgaat ggcaggcatc acttaaagtt tccaaatgtt 3018481 ttttaagatt ttaataatca ttttcaatac ccatatcatg ataaatgttt actagtaaac 3018541 attagtcatt ttatcccttt tccttccaaa cgtcaatatg atctgtgccc aaatatttga 3018601 aaataaatgt aaacatcaca ttttccacac actttttaca cgcatattca gcatgacata 3018661 tcaacaaata gtctaaacac caacaattga caacgaaaac aagaaaagat aaaataaaat 3018721 tgttcaccag taaacgattt gttttattgt ttcatcgtaa actattattc ctaagaaaga 3018781 aggtagccta tgtctgattt gacaaaacag atgatatacg acatatacgt gagactgctg 3018841 caccttaatg aacaaaaagc gaacacttca cttcagcaat tttttaagga ggccgcagaa 3018901 gaggatgtag ctgaaattcc caaaaatatg acaagcattc acgtcattga ctgcatcggc 3018961 cagcatgaac ccattaataa tgccggaatt gccagaaaaa tgaacttatc gaaagcgaat 3019021 gtaacgaaaa tcagcacaaa actgatcaag gaagaattca ttaacagcta tcagctgaca 3019081 gataacaaaa aagaagttta ttttaaatta acccgtaaag gcagacggat tttcgactta 3019141 catgagaaac tgcataaaaa aaaggagctg gctttttacc aattcctcga ttcattttca 3019201 caagaagaac aaaaggctgt attgaagttt ctagagcagt tgacgtcaac acttgaagca 3019261 gaacaaaccg atgggactcc agacaaacct gtaaagtaaa caaaaaggcg gtgtacactt 3019321 tggctcatac aaaatcaaag gcagtattga tcttatacac tgtttgcttc agtgcatttt 3019381 ttgcatcttt aagccagaac atttattcac ctattcttcc gatcattaaa gaatcattcc 3019441 atgtttccac agctatggtg aacctgtcag tctcagtttt tatgattgtg acagcaataa 3019501 tgcaaattat attaggagcg atcattgatt ttaaaggcgc tcggatcgtc ttgattaccg 3019561 gtattctggc aacggcagca gccagcatcg gctgtgcggt gactactgac tttaccttgt 3019621 ttctgatatt cagaatgata caggcagccg gttccgcagc actgcctctt attgctgcca 3019681 caacgatcgg acagctgttt acaggaaatg aacgcgggag tgcaatggga acgtatcaaa 3019741 tgctcctgtc tgtcgcaccg gctattgctc cagttctagg aggattcata ggcggagcag 3019801 ccggatacga agggattttt tggatacttg cggccatctc tatcgttttg ctggtgacaa 3019861 acagcatcac ctttcctaaa gattctccaa ctgaatctat gcagcaagcc aaaggcaatg 3019921 tgttcgctca ttataaatca atatttacaa atcgaacagg gaacgtcatt ttgactttaa 3019981 gttttgttct ctttttcatt tattttgcag taattgtcta cctcccaata ttgctgacag 3020041 agcattacca tatagatgtg ggtatagcag gactgttata tttgccgctg gcgctgagca 3020101 cgattgcagg tacgtttctg tttaaaagaa tacaggcaaa aatcgggctg cacaccttgt 3020161 ttatcggaag caatgtgatt gccgcctgca gcatcatttt atttgctgtt acacattccg 3020221 tttctctcgt tctcatggct ctgacgctgg cactgtttgg catctcgatg ggggttattc 3020281 ctcccttgta ctctacaatg attactaatg aatttgagca caacagaggg agtgcaatcg 3020341 gaatgtttaa ctttatccga tatacaggca tggcagcagg tccgatggta tctgcctact 3020401 tgctcacaat gatgccgtct gccatgtcct ttagcctcct aggccttgga tttgccgcat 3020461 tgagcttttg ccttcttccg ccaatgtttt cgccgcagaa gcgcacgaaa caaaaaaagc 3020521 accacatgta aaaaagctgc ctttgcgggc agcttttttt atttttttct aagcggctct 3020581 aaaatgcctt tttgaatcag caaatggaag accgacagga taacggatgc ccatatcgct 3020641 gtgccgaagc cgtcgatttg aaagctgtca cccataatgg acgcggtcat cataagcgtg 3020701 atggcgttaa tcacaaacaa gaagagtcca agcgtcacca tggtgaccgg cagtgtaaat 3020761 ataattaaaa gcggtttaat cagcacgttt aagatcgata aaatgaggct ggcgataatc 3020821 gctgccccaa tgctgctgat atggatggag tcaatatatc catcaatgac gattaataac 3020881 aatgcattga ctaaaatgct gactgcccat tttaccatgt catttcatat ccctttctga 3020941 cgggacgata aaaatccaaa tgatataaat gagcaaaacc ggcaagacac ttgtcataat 3021001 ggctaagatg acagttatga ctctgaggag tgatgcgtcc caattgaaat attccgcgag 3021061 acctccgata acaccggcga ttttcttatt tttttctgag cgataaagct tattcattcg 3021121 atcacctctg tgagtacttt agtttgatgg cgcctgttag tgattctgag aagacggtga 3021181 tgttttgatc atgtgcctga tttgaagtga acatcatttc tttttgaatc gtatcatttt 3021241 tttccttcag catctctaca tccattaatt catgggacag cgtaccaaga ttgcttttca 3021301 gctctgcctt cactgcgaga tcgtccggaa ttgcaagctc tacatttcca gtcgttgttt 3021361 ttgcataaat ggagcggcag tctgattctg ttacgttaat cgcaatattt ccgttaaagc 3021421 tttgaacgtc aatggattcg cttttccctc ggagatcgat caatccgtta atggtttccg 3021481 cttctatcgt accgcagctg tggcttgcga gcttaatttg cccgttggcc gtttcagcta 3021541 tggctttttc ggctgttaaa tacgagaacg acagcacgcc gtttgtcgtt ttcgctgaga 3021601 actcttttac atgtaaatgt tcccctctga ctggaccgtt aaacagcttc acccgaatct 3021661 tatcatactc cttctgagga atatacaaag tgacattcgt tttcatcgtc tttttctcag 3021721 tacggataaa aaacttatta cctttgattt cacattcaat atgctgaaga aatgcgtgtc 3021781 tcgccgcatc ctggctgtca gcgcgatata ccttcgcctg gcattccgct ctgatatcgt 3021841 catcttccca agggacgata tttacgctgc cattggcaat ttgcagctca acactggaaa 3021901 agtcagtatc tttaaattga aaaatgtgct gaacatcata cgcatggcca aagtttaaat 3021961 caaggtcaac ttccttgacc tttttcacag cagaatcaat ccagtcaaac agcttggctc 3022021 ctaaagacgg tttgccgctt tctttttttg ccgttgtaaa tggctcttcc tcgtcatgaa 3022081 cgtgaactga gagcgctgtg attttctctt ctttttcctt gtagtcgctg tcaagctttt 3022141 caatcagtgt caaagcttct tgtgctgtaa gctttccttc ctcaacaagc ttaaggattc 3022201 gttccttttc ttgcttcatt acgatctcct ccccattgtc tacttatgct gcacgcagga 3022261 ccttaatgcc ctgaatcaca ttccaaatga taatgccaat gacaactaag aaataaataa 3022321 ccgctccccc gatgattaca aatacaggaa gcaagctgtc tccatcaatc gcaacggctc 3022381 cgccaagtaa agcaataaaa aggaacagcc agccgacaaa cggaacaatg tgagaaataa 3022441 gagagcgtat cgcatggcgt tttgtttctt tctcatttac aacaaaatat gcgacaatcg 3022501 gcacaatgat tggcgcaatg aacacactga aataacaaag tgatgcaata atagcttgat 3022561 tacggttcaa ttcattccac actcctattg tgaattgtcc atgacaaaag atcagggacg 3022621 ttttacttat ttatacgttt aaaatctctt caggtttcaa attcattctt tagacatgct 3022681 ccgatttacg gaaattggat tttaaaaagt tttagaagta gaatcttccg gctataccga 3022741 ttacaatatg taaaaagctt acggcaacca aggaggctgg acaagcaatg gagaaagatc 3022801 ccagtgacta tacagtaaca caagaatcag tgttaaagct gattcaggaa caaaaaagaa 3022861 tgaatcgtga aatgatcacc gagcttgagc agattcacgg acccttcccg atctctcacg 3022921 atatccaata tataaaagtg ctgctcgaca gcagcaacac acatattgtt caagatttaa 3022981 tgagtgtaag taagcagctg tataagaaga ctttgtaatt gcggaaaaca tatcattcat 3023041 tataactgaa acaaagctaa aggttagatg acaatatctt gccttttttg ttttgaaaaa 3023101 acaagtgatt ccctggctgt cacaaaatga ttgtaacaaa aaaagcctgc cggcacatcc 3023161 agttaatgga ctctgtcggc aagctgtaac tatcagaaag agatagccgt tcaaaattaa 3023221 cgtaacaatt gaagcacgtt ttgcggctgt tggtttgctt gagcaagcat cgcttgagaa 3023281 gcttgagaag gaatgttgtt ctttgtgaac tcgctcattt ctttcgccat gtcaacgtca 3023341 cggatacggg actcagcagc tgtcaggttt tcagaagaag caccaaggtt gttgattgtg 3023401 tgctctagac ggttttgtac cgcaccaagt ttagcacgtt ggtttgagac attgttgatt 3023461 gcagtatcaa tactttcaag ttgtgtatca aaaggagtat tagcaaaatc tgttacatta 3023521 agtgcgttta ctcctaaagc agttgatgac atgctgtcaa tgttaactgt aagctgctgg 3023581 ccagcatttg ctccaatttg gaaagtgaaa ccatcagttt cagtaccatc taataacttt 3023641 ttgccgttga attcagtacg atttgaaatg ccatcaactt cctcaataag cgcatccatt 3023701 tcatctttaa ttgcaccaag atcttctgct tgttgtgtac ctgtgtttcc tgcttgaaca 3023761 gtaagttcac ttctaaacct attatgccgt aaagaaaaag cttgcctgct aagcccaagg 3023821 atggacttgc cgacaagctg tcccctctta acagagggtt ttaagatgta gctgtttctt 3023881 ttgctttcaa gagcgatttc atgcgtgttt tgtcacgttc gataacaggc tttaaataac 3023941 ggcctgtata cgattcttca acttcagtga tttcctcagg cgttccagac gcgacaatgg 3024001 ttccgcctcc ggctccgcct tccgggccca aatccacaat gtaatcggcc gtcttaatga 3024061 tatcaagatt gtgctcaata accagtacag tgtctccgtt gtctaccaac cgttgcagca 3024121 cgacaagaag cctggcgata tcgtcgacat gcaaacctgt cgtcggctca tctaaaatgt 3024181 agagcgtacg tccggttgag cgtttgtgca gctctgacgc gagcttcacg cgctgcgctt 3024241 ctccgcctga caaggtcgtc gccggctggc cgagcgtaat ataacctaaa ccaacatcat 3024301 aaagggtttg gagcttgcgt ttgattttcg ggatattttc aaagaaagaa agagcatctt 3024361 caaccgtcat atcaagcaca tcagagatgc tttttccttt gtacgtcact tcaagcgttt 3024421 cacggttata gcgtttgccg tgacacacct cgcatggaac gtatacgtca ggaaggaagt 3024481 gcatttcaat tttaataatc ccgtctccgc ggcaggcttc acatcgtccg cccttcacgt 3024541 tgaagctgaa acggcctttt ttatagccgc ggaccttcgc ttcatttgtc tgcgcgaata 3024601 catcacgaat gtcatcaaat acaccggtgt atgtcgcagg gttggatctc ggcgttcttc 3024661 cgattggcgc ctggtcaatg tcaatgactt tatctaaatg atccaaacct ttaatctctt 3024721 tatggctgcc gggcttcgct ttcgctttat gaagcttttg cgccagcgcc ttatgcaaaa 3024781 tttcattaac gagtgtactc tttcctgaac cggaaacacc tgtaactgct gtaaacgtcc 3024841 caagcgggaa cttggcattc acttttttca ggttgttttc tgatgcacct ttaatttcaa 3024901 tgtaacgtcc gtccggcttt cttctttcag gaggcaatgg gataaacttt ttccctgata 3024961 aatagctgcc cgttaatgaa tttggatctt ccatcacttc ttccggcgta cccgcagata 3025021 tcacctgtcc gccgtgaatg ccggctcccg gtccaatatc tattaaataa tctgctgcca 3025081 tcatcgtgtc ctcatcatgt tcgacaacaa tcagcgtgtt cccgaggtct ctcatatttt 3025141 tcagagcgct gatcaagcgg tcgttatcac gctgatgcag accgatagac ggctcatcta 3025201 aaatataaag cacaccggat aaacgcgagc caatttgagt cgccagcctg atgcgctgcg 3025261 cctctcctcc ggacaatgta cccgctgccc tgctcaatgt caggtaatcg aggccgactt 3025321 tgtccagaaa gcttaagcgc tccacaattt cgcgcaaaat caaattggcg atctgcatat 3025381 ccttctcaga aagggtaaga tctttaaaga aggcaagtgc gtcggcgaca gacagctcgg 3025441 taattttccc aatgtggcgg ccgtcaatca gtacggcaag cgcctctttc tttaaccgat 3025501 agcctttgca cgtcggacaa gacttctgag acatatactg ctccatttgc tcacgtatga 3025561 aatcggagcc tgtctcctta tagcgtcttt caatgttgcg caatacgcct tcaaattgaa 3025621 tttcaccttc gcggatttgt ccaaaatcat tttcatatcg gaaataaatc aggtcatccc 3025681 cgctgccgta cagcacttta tccagttgat gcttcggcaa atctttgacc ggcacatcca 3025741 tatcaatccc gtagtgggtg cagactgcct caagcagctg aggataatat tgtgagctga 3025801 tcggtgtcca aggggcgacc gcattctcct tcaatgacaa atcttgattg gggatgacaa 3025861 gatcggcatc cacttcaagc ttcattccga gaccgtcaca cgtcggacac gccccgaacg 3025921 gactgttaaa cgaaaacaga cgcggctcaa gctcaccaat tgaaaatccg cagtgcggac 3025981 aggcatgatg ctcgctgaac atcagctctt cctcaccgat gacatcgatc ataacccgtc 3026041 cttcacctaa acgaagcgcc gtttccaatg aatctgacag ccgggctgcc acgccttctt 3026101 tcacgacaat ccggtcaatg actacctcaa tggaatgctt cttgttcttt tctaattcga 3026161 tatcgtcgga aagctcagcc atctcgccgt caattctgac tctgacatag ccttgtttcc 3026221 taatctgttc aagcactttg acatgagcgc cttttcggcc cgagacaatc ggcgccagca 3026281 cctgaagctt cgtccgttcc gggtattcca gaattctgtc caccatttgc tcgatggtct 3026341 gggatgtaat ctcaattccg tgttccggac aatgaggctt ccctactctc gcatataaaa 3026401 gacgcagata atcataaatc tcagttaccg taccgacagt agacctcgga ttgcggctcg 3026461 ttgttttctg atcaatgctg atggcgggag agagcccctc aattgcatcc acatccggct 3026521 tatccatttg ccctaaaaac tggcgggcat aggcagacag cgactcgaca taccgtctct 3026581 gtccttcagc atatatcgtg tcaaaggcaa gggaggattt acctgatccg gacaaacccg 3026641 tgacaacgac aagctgatct ctcggaatcg ttacatctat atttttcagg ttatgcgccc 3026701 tggctccctt cacctctatc cgatccatag ccatttgttc atcatccttc cgcttttagc 3026761 tctaaaagta aatcgcgaag ctccgcggct ctctcaaagt caagcgcctt ggcggcttcc 3026821 ttcatttcat gctccatctg ttcaacgact ttctggcgtt ctttcttcgt cattttcgac 3026881 agcttcggcg cggcttttgt tttgtattcc gctttatcct cagctgctac tgtggcacga 3026941 atgacatcgc gaatttcttt atttatcgtt ttcggcgtaa tgccgtgctc ttcgttaaac 3027001 cgctcctgct gctcgcggcg gcgttttgtt tcattaatcg caatttccat agacttcgtt 3027061 attttatcgg cgtacataat gacgcggcct tccgcatttc tcgctgcccg tccgatggtc 3027121 tggatcagcg accgctccga acgaaggaaa ccttccttat ccgcatccaa aatcgcaaca 3027181 agggatactt cgggaatgtc caaaccttcc ctcagcaggt tgatgccgac aagcacatcg 3027241 tacttgccaa ggcgcaggtc gcggataatt tcaatccgtt caagcgtctt gatctcagaa 3027301 tgcagatagt ttactttaat gccgatttcc tttaaataat cggtcagatc ctctgacatc 3027361 ttcttcgtca aagttgtcac aagcacccgt tcattccgct cgattcttgc ttgaatttcg 3027421 ccgatcaagt cgtcaatctg accttcgatt ggacggacgt caataagcgg gtcaagaagc 3027481 cccgtcggac gaatgatctg ttcgaccatt tcatctgtat gttcaatctc gtacggccct 3027541 ggtgttgctg atacatacac gatattgtgc atatgctttt caaattcctc aaaacgaagc 3027601 ggacggttat caagcgctga tggaagccgg aagccgtgat ccacgagcac ctgtttccgc 3027661 gcctggtctc cgttaaacat gccgcgcacc tgaggaattg tcacatgcga ctcatccacc 3027721 acgatcataa aatcgtctgg gaaataatca agaagcgtat acggcgttga acctggaggc 3027781 cgcagagtca aatgtcttga atagttctcg atgccggagc agaaacccat ttcacgcatc 3027841 atttcaagat catatcttgt ccgctgctct aaacgctgcg cttcaaggag ctttccgttt 3027901 tcatgcatga ccttcagctg ctcctcaagc tccttctcga tattttgaat cgccttctcc 3027961 attttctcgg cccgcgttac gaagtgggat gccgggaaaa tcgcaacatg atctcggtcg 3028021 ccgagaattt ctcctgtcag cgcatctact tcccgaatcc gttcgatttc gtcaccgaaa 3028081 aattcaactc tgacacaatg ctcatcacgg gatgccggaa agatttccac tacatccccg 3028141 cgcacacgaa atgtaccgcg ctgaaagtcg atatcgttgc gggcatattg gatgtctaca 3028201 agttttctga gcagctcgtt gcgctcaatt tccatttcag tccgcagtga cacgaccatt 3028261 tcccggtatt cctcaggcga accgaggccg tatatacaag acacactcgc aataataatg 3028321 acatctctgc gctcaaacaa agctgatgtg gcggagtgtc tcagtttatc aatttcatca 3028381 ttaatactag cgtctttctc tataaatgta tccgtttgag gcacatacgc ctccggctga 3028441 taataatcat agtagctgac aaaatactcg acagcattgt tcggaaaaaa ttccttgaac 3028501 tcactgtaaa gctgtccagc aagggttttg ttatgggcaa tcacgagagt cggcttattg 3028561 acttctttaa tcaaattgga caccgtaaat gttttcccag ttcctgttgc acccagcaga 3028621 gtctgatgct tcttgccctc ctgaattcct ttcacaagct tttcaatggc tttcggctga 3028681 tctccctggg gctgatattt cgagactaac tcaaagcgat ctttcacaaa aataagcctc 3028741 cgtttcttta acgaaatctt cctatagata tagtaacaca atggaaagca aaatcactaa 3028801 aaatacgaac taaagttcgg tggtttttta tttccagctg tttttgtgta taaaaaacct 3028861 gcttttaaaa cgtaaaagca ggtattcagt ctttatattc attatgtccg atttattctt 3028921 cttttttctc tgcagctttt ttggccatat acagtccgcc agccacaaga gacacaacat 3028981 ccaatcctac aataaaatac gtttctgtat agccttttaa ataagaggca aacagcaatg 3029041 cagctgttaa agcgatcgcc acataatgat taaaggtgac tctagtaaat agaacaacaa 3029101 gcataaaagg gaaaaacaat gcaaaaacgg cttttgtaat caacaaaaac cctcctcagg 3029161 gattcttcat ctgatctgat tatagtaaaa aatgaagaat cggacaatcg tgcattcgct 3029221 ccctctactt acaccatacc ccttttcagc caaaatcaat caccatattt gcattttggt 3029281 gccggtcaaa acttattcca tggtgccgct gttctaatca gcggcacttt ttttattaca 3029341 tcatcaagtc cgccgccaga ttccgagaat aaaagaaaat aggcatacag taccagtacg 3029401 gccgcatttt tcaggataat ataaccaact taactattca ttttatttag gactttctgc 3029461 gtttgacagc attttcctga aaacctacaa ttaaatgata gtgtttacta tcatttttta 3029521 aacacaggct ccgcaataaa aagactagag agaaaaacaa aatgaatgaa gaaaagaggg 3029581 gtttcaaata tgtattctgt tttatttcgc caggcagaag agtccagcca gctggctgga 3029641 gcaaaaggaa tgaatttgat taaattgacc aaacacggtc ttcctgttcc ggacgggttt 3029701 attattcaaa cgaatgcgct cgcacgtttt atggaggaca accagcttca agagactagt 3029761 gaaaacgtcg aaggcgggat catttccgga acattttcgg atgagctgaa agatgagctg 3029821 actagttcct tttataagct tagagaatca tatcgatccg tagccgtgcg ttcttcgtct 3029881 gcttcggaag atttagaagg cgcctcattc gcgggtcaat atgaaaccta cttaaatatc 3029941 aaaacagagg aagagtttct ggctaaagtg aaagaatgct gggcctcatt tttttctggg 3030001 cgggtcagca gctataagaa aaaaatgaac aatcaaatcg cagagccgtt aatgggaata 3030061 gtcgttcagg ggctgatcga ttcagaaatg tcaggtgtta tcttcagccg caaccctgtt 3030121 acccatgatg atagagagct tttaatcagc gccagctacg ggttgggtga agctgttgtt 3030181 tcaggaaatg ttaccccaga cacgttcatt gttaataaat cttcgtttga gattcagaaa 3030241 gaaataggtg caaaggaaat ctacatggag tctgcggcag aaggaattgc tgaaaaagaa 3030301 acgagtgaag acatgcgcag ccgtttttgc cttacagatg aacaagtgat tgaattggct 3030361 gaaatcacaa aaaaaaccga agacctgtac ggatatcctg ttgatataga atttggaatt 3030421 gctgatcatc aaatatacct tctgcaagct cgcccgatta caaccattga tcaggacaaa 3030481 aaagcggcag aagaaaaacg cagcttcatg attaccgaca ctgatatgaa tgatttctgg 3030541 cttaacatgg agtctaatat tgaaggtccg gtgagtccgt tattttcatc cttcatcgtg 3030601 ccggcattgg aatatggctt gaagaagagc atgcaaaagt ttccgattgg tgtagttgtt 3030661 gatgaagtaa aactttatcg cggacatatt tattccaaaa accaaggcgg acagcagcct 3030721 ccttctgaag actgcggcaa agagcttttc ccgattttat cggagcatat gtatgacatc 3030781 atcaatcaca catacctccc tttttaccgg acactggacc agctcgcaca aactgagcat 3030841 accgcagaaa gcgcactgga agcttttcaa aaactaaagg ccttttatct cacggcttat 3030901 gaagagcact ttaatatcgt tttcccgcaa atccttttaa caaacaaact gcaagcgatg 3030961 tatcaggaca ttcaaggaga gtccgaaaac gctcattttt acgagatgct gacaggaaaa 3031021 atgaacaaat cactggaaac ggaccgttgc ttatggctat tttctgtgga agttcaggag 3031081 aacccgaacc ttctggccat ttttgaaaac aacaagcctg aacagctcca ggagaaattg 3031141 gaacaaacag atgagggaag acacttcctg aagaacgtcc atgaattctt gcaagaatac 3031201 ggatggagat ctgttaaaag tcatgatctg attgaacaaa tctgggtgga aaatccgtat 3031261 ttcgctctgg ccaatattca aaattatgtc cgtaatggct atcattttga caatgaattt 3031321 cagaaaacaa aagaaaaacg agagaaatta tacaatgaat tcttggaaag catagaagat 3031381 cccggtttac gcaccgaatt tgaccgctat tatcaatgga cactgaactc tgcaaatata 3031441 aaagatgatc accactttta tattgacgcc atgctggatg ccaaggcgag aatctttctg 3031501 ctgaagatag gtgaattgct ggcggaaaac ggtgtcattc aagatcggga ggacctttgg 3031561 ttcttatatg acgacgaagt ggaacaagcg cttcttcacc ctgtatccct gcaagaaaag 3031621 gctgaaaaac gcagacagat ttttcatgag tatgagctgg cccaagcccc ggcctacctc 3031681 ggcaccccga caaaagaaca gctcaaagca gctgaagaaa ttgtcggcgc tgtgatagag 3031741 gatgaaaaaa acacagagaa tcatattttt ggcattgcgg catcaagcgg cattgcgaca 3031801 ggtccggtga aaatcattcg ggacgccaat gaattttctc aattcgcgcc tggagacgta 3031861 ctcgtttgca agatgaccac accgctatgg accagcctgt ttcaagacgc caaagcgatt 3031921 attacagaca caggcggcat tttgtctcac gctgcgatta ttgcccgtga atacggcatt 3031981 ccagccgttc tcggcacacg cacggcaacc gaaagactgc gagacggtga catcatcact 3032041 gttgacggaa gcagcggcaa aatcacagtt gtcagccggt cctgatgcgt ccccctcttt 3032101 cttatacaag cggggcgggt gtatacttgt cctgccagta tattcgtgag gtgaaacgta 3032161 ttgagaccga caaacaagag aatccttgat gctgccatgc agctgctcgt caaaaaagga 3032221 tatcgcgcaa cgactacaaa agaaattgca gaaaaagcaa atgtaagtga agcgacgatt 3032281 ttcaggaact ttaaaaacaa acaaggacta gttgaggctt tgctttctca gcattcttca 3032341 aacagaggca gcattttgga acaaacagaa ggggatttgt acaaagacct gcttcatatc 3032401 ggaacctgtc tcttggagga gctcgaacat agaaaagata tcattaaaat cagctttcgt 3032461 gaaccggcca tgtttcagga tgtcattaac cacgtcactg aatatcccca atctatgaaa 3032521 cagctattgg ttgattatct caaaacgatg ggtgagaaag gggttattca gacaggaaat 3032581 gaagcggaac atgccgacgt gttcatgtcg attatcttcg gttatttcat tcaccgtctc 3032641 cacttaggag accgggtcat atcaatgccc caggaaaaaa tgctggagca tagcacagct 3032701 ctatttgtca aaggaatttc tgctgattaa ctccttggca taataaaaag gaggatccca 3032761 atgagctcaa gaaaagaatg ggcgctgatc gtctcgctat tattgggggc cattctggtt 3032821 cccattaact caacgatgat cgcggtcgcg ctctcatcta tttcccatac gtataacgag 3032881 tccatcgcaa gcatcacttg ggtggttacc gtttatttaa tcgtgatggc agtcacacag 3032941 ccgattgcag gaaagctcgg tgacatgtac ggcaataaaa caatgtactt atggggagtc 3033001 ggcctttttc taatcgcatc tctaggctgc gccctttcac cgagtctgct cctgttaatt 3033061 gtctttcggg cattgcaggc tgtcggcggg gcattgctta cgccaaacag cattgccatt 3033121 atccggcatg ttgtttctga aaaacgccta ccgaaagtgt ttggattttt cggactgggc 3033181 gcgggacttg gtgcagcact cgggcctttt atcggctcta tactgattga cagcttcagc 3033241 tggcattcga ttttttgggt caacatcccg ttcctcgcca ttgctttatt tacggcatta 3033301 acgatgtttc ctcaatataa agaaaataaa tctgacgcgc cgctggatat catcggctct 3033361 ctcttgcttg caggcagcat cgtttccatt atcctgctga cgaaaaatga ggctccatgg 3033421 ggatatactg tatacagtgt attgatactt ctttttgttc cgcttttttt cagaagagaa 3033481 aaacgtaccc agcaccccat cattgacttt gcactgttta aaagctcaac ctttacaaat 3033541 gcgaatctat cagtcttgtt aagcaatttg atgatgtatg ccgtcttatt gattatgccg 3033601 ttatttatga cgaaccaatt tgggcttaat acatctaaca gcgggatggc gctttctgta 3033661 ttttcgatct tcatgtcagc cagcaactgg gtgggcgcgc agctccatca caaatgggga 3033721 gccaaaaaaa tcatttttct ttcatttgcc atgatggctg gtgcgaatct attatttttg 3033781 ctgttaagca gctcgcattc tgtcttgttc ctcatgctct ctcttatcct tggcgggctc 3033841 gcttccggag tcggtctgac cagcatgcag gtttcatccc ttgccacagt agaccccggt 3033901 atgtcaggag tggcatctgg gattttctcg accttccgtt atttcggaag catcatttca 3033961 tcagccttaa ttggcctgat ttcgggatat cacaccctat ttatgattct ctttgctgta 3034021 tccatcatcg gcgtttttgt ttcattgggc atcaaatctg atgaaacggc acggatagaa 3034081 aaaaactcag cgtaacacaa aacagcccgg catcgcatca tcctgcggtg ccgggctgcc 3034141 ttttatgatc ccgaagcgac tgcttcgtct tcacggtcat cctttacgaa gaggatgccc 3034201 aattcatgat gttctccttc ataagaagct cgctggtcaa aacgaatttc tccattcaaa 3034261 ccgataattt caagctttac atatgcacgg ttatgctgaa gcgcttcata gaaatcagaa 3034321 acgttcttaa ccggtatgcc attgactttc gttatgattt ccccgatttt caattccaga 3034381 tcctcagccg gcgtattggg gataatccca agcaccatta agccctgatc ccttttcgag 3034441 aaataaaacg gagccgcgtt atcattcact ctttgcttta tggacagaaa aatacgccct 3034501 aacaaagcgg tacagaccgc tgcacccgca agcggcgtcc acagtaagct cgctgcaccg 3034561 agaactgcga cggcaagacc gagaatacaa acgcgtttcg ctgtgatcct tatactcgtt 3034621 tcaggcagcg atccctgtac cctttgtcca aatccgacaa agtaaggaat ccatagaaaa 3034681 tggaatgagc cgccgggaac cgtaaacacg ggccaccagc taaggtgcga ttctaaacca 3034741 ttaccgggca cgagaaggaa cagcggcaaa agccaaaccc ggtttgccag ctgctgtccg 3034801 atcggcaaac cgcggctgct tacgacaagt gccggtgatg ttctcacatg cgcagaacga 3034861 taagcaaccg ctccttcagt gataatcagc aaacctagaa acacagccac agccggccaa 3034921 acaactgcaa atccttgcgg aaatctctcc agaaagggct ccgcctgata tatttgcagt 3034981 ccaaaaccta tcagcatact cacactgacg atatatgcag cagacatcca gtttgcgcga 3035041 agagtgaacg ctgccgctgc agtgataacg gcaataatcg caagtaaacc gagaggaatc 3035101 gatattccga gtccacctaa aataactgac aaaagaagac ctggaatcag tccctttgta 3035161 tatgtaaatt tcagatcatc ataaatatct gctattcttg tatgaaaggt ttttcgttcc 3035221 cgtttgattc ttacatagcc gaaagccaag gttatgatga taaaaaacca gaaaagcggg 3035281 tgtaagaaga acaagcccgc gctttttaac agttcaattc cccattgaac agacactatc 3035341 tctcaccgcc tcaagccaaa catgttactc atattctatc aaatattaaa tggcttggat 3035401 atcctcagga gagtttatct ctcttgcgtc atccacagcg tgacattcga tagtgaaaaa 3035461 tcctttaaat agtggtttac atccacatcc aataacccgc tgattagatg catcgacctt 3035521 tttatatctg tcagattaat tcctaatcgc ttatggtttt tcattaagta gttaaaataa 3035581 tgtttggcgc attcctcatt aatgtcattt actgattcga cattggtgta attgaccaaa 3035641 tatctgctga acagcataag aagacttagt gcttttgtag ctgaaaatgt tacgtcttgt 3035701 gttctgtctt ttaattgttc cactaattca taatattttt ttttcacgca caatacttgc 3035761 cctcttcaat tgtgaacccc cattttcttt atacagataa gcacgggcca gtataagcag 3035821 cagtactgga gtgctaacaa gcattctcgc taacgttact ctttaaatac ctgtcgttca 3035881 gctgccatta acctgattac tgttcttttt agaaccttct tatattgtat gaagtaaaca 3035941 aagactaggc aacttgcaaa agtttcattt taaatgcata ttaactcgtt agaaagtctc 3036001 tctcatatat tgatatcggg taataacagt cctttataaa tgtttatttg tgaaaatttt 3036061 tttaatttct tgtcaaaaac tcatttttta tgtgacttat gatccataat ctctttaagc 3036121 acaaagaaac aggagatgaa ataccatctc ctttaattga caaataatga tttcaatgct 3036181 gtttgaagct gcaaatcatt tttttcatct gattttttct tttctatctg ctgatttaat 3036241 gtctctgcag tgcgagtgtc gatcacaccg gttttattca gcttgttttg atcctgaaaa 3036301 gccataaccg cttttttcat gtctttgctg aaatagccat cctcacgtcc cggatcaaag 3036361 ctgagacctt ttaacaatac ctgcgcatgc ttgacgtctt cattgttcat gtccacttta 3036421 agcggctctt tcagctgtaa gggcccggcg gaaaaataat cgggctgctt aatcgcaatg 3036481 gtcggttcaa ttcctttctt atgaatccag tttccatttg gcgtcagcca cttgtaaagc 3036541 gttaatttga tgttgctgcc gtcccccatt ggcacagcct gttgaaccgt tccctttcca 3036601 aaagacgtat cgcctacaac atcataatgg ccagcttcct ttaatgcgcc ggcaagaatt 3036661 tctgatgcag aggcacttcc tttatccgta atcacattga cagggtacgc ttttttatgg 3036721 gtcaatgttg aaaaataacg ttttttatct ccattgcgtt cagcaatctg aatatacggc 3036781 tgatcctttg taacgaaatg cttaagaatt tcttccacac tttgaagata tccacccggg 3036841 ttgccgcgta catcaatgac aagtccttct atttcttttt tctcaagctc cctcagcgct 3036901 tttgcaaaat cctctgcggt gtgctcagaa aaagtagaga tggcaatata tccgacagaa 3036961 tgcccctgta cttttttctc tgatgcaaaa accgtttcga gcggaatctc agctctcttg 3037021 atccggaatg acaactgctt cttcgttcca ggccgctgaa tcttcattga aacgctggac 3037081 cctttttttc ctcttatttt taacacagcg tggtttaaat ccttgccggc catcgattct 3037141 ccattgatgc tgataatttc atcattaggc ttcaacccgg ctttttccgc tggcgatttc 3037201 ttgaatggag aaacaataat aattttgccg tcttccattc caacctcagc cccgatgcct 3037261 tcaaatgagg aatcaagaga atcagaaaat tgcttagctg tctgcttgtc catgtaaaca 3037321 gaataaggat catttagcgt agacagcatt ccctggatgg ctccctcgag cagcttttct 3037381 ctatctactt tttctacgta ctcattcgaa attaactcat acgctttttc gattttgtcc 3037441 atagctttat cccgttcaga gtcagcttgt gccgtcgcgg gaactgctgc agtctggggc 3037501 ttatccatct caagcaggtt gattcccgca tatacaccgg cgcctccgaa cagcatgctc 3037561 cctgctgcta tcacagccat tattttttga ttcatccttt actcctcctg tatgccagac 3037621 tgtctttacc aaaacctaga gatagtatat gtaaaggatg gagatttcat gtaatcatag 3037681 aagaaaaaga aggcaaatga aaagccgtcc cgaaaacgga acggcttttt cactttatac 3037741 tcgcagaaac ttgcggatgg aagtcagact tccccatact ccaattactg cgccgattgc 3037801 aatcagcact agcgaaactt ggaatacaaa tggattataa ggaagaagag agacaaatga 3037861 tccttgaacc tttggaacga cccatccgat gacgtattgg taagtgctca gcaccagtgc 3037921 aatcggaatc acagaaccga atacgcctag cagcaatcct tcaaggaaaa acggccagcg 3037981 gataaaccag tttgtcgcgc cgacaagctt catgatttca atttcttttc ttcttgcgaa 3038041 aattgtaatt ttaatggtgt tggaaattaa gaacatcgcc gtaaatacca ggccgataat 3038101 taacgcgatt ccgatgttgc gggaaacgcc gaccacttta aacaaacggc tgacctcttc 3038161 ttttccataa gtgactttat aaacatgatc cattttttcg atctttttcg ccacgttcgg 3038221 cgtatcatgc ggatctgtcg ttttgacgac aaacgcatca ttaagcgggt tttcctgatc 3038281 cttcattgtc agggattttc cgctgtcacc aaaactgtca accagctggt caagctcttt 3038341 ttctttagat gaaaaagtga cactctgaat gcccttcagt tccttaatat cgttctgaag 3038401 cttgtcctgt gccttctgat ctgcagtcag atcaatcagc actttgattt cgacttgttt 3038461 ttctgcattc gtggccatgt tattcaaatt cagcataatc actaaaaaca cgccgactaa 3038521 aatcagcgta acggttacag cactaatgga tgcaaatgtc atccatgtgt ttctcccgag 3038581 agatttaaaa ctctcacgca agtggcgccc gagaatttta atcatatgaa ccatactccc 3038641 ctcttgactc atcacgcaca atgataccat cttcgattgc aatgacacgt ttcttcatgg 3038701 tgtttacgat ttctttatta tgtgtcgcca tcacgactgt tgtcccgcgg ttgttaattt 3038761 cctccagcgt cttcatgact tcccaggacg tatccggatc aaggtttcct gtcggttcat 3038821 cagcaatgac aacatcaggg ttgttcacaa ttgatctggc aatagataca cgctgctgct 3038881 ccccgcctga aagctggtca ggaaattgtc gcgctttatg cttcagctgc acgagatcaa 3038941 gcacttcaag cacccgtttc ttaatgacag acggctgttc tccaatcact tcaagggcaa 3039001 atgccacatt ttcaaaaaca gtaagtttcg gaagaagctt gaaatcctga aagacaacac 3039061 ctattttgcg gcgcacgaaa ggaatctctt tttctttaat tgtcgcgaga tctttatgat 3039121 tgattaaaat ttgtcctttt gtcggttttt cttctctgta aatcatttta ataaaagtag 3039181 atttacctgc tccgctcgga ccaacaacat acacaaactc gccgggatga atggtaacag 3039241 aaatcccatt gagtgctttt acgccgttcg gataggcttt atatacttcc ttcatctcta 3039301 tcatgaaatc acctaatctt ttatatcatt ttatctatca cacggtcata ctcttcgaat 3039361 gcattcgaca atttatgacc cattcatttg taaaaagatg aaaaatctga aagttccctt 3039421 tttcaataca cttcattata cgtcaaattt agacataata ctattacagt ttcttttcat 3039481 tcatattgtc aaggcataaa aacatccttg ccagcactcg gcaaggatgt ttttatctta 3039541 ctttttttct gacagccatt tggcaataac agcggcttcg ttatcatcta caagcccctt 3039601 tggcatattg ccgcggccgt ttttaataat gctttcaatt ttgtgttcat cgtatttgcc 3039661 tccgacctct tggagattag gccctgacac accttctaaa tccttgccgt ggcagcctac 3039721 gcagctttgc tgatataatt cttccccttc agatgcagtg gcttccgtct tgctgccagt 3039781 gtctgtcttc tcttcttttg catcgtttga tccgcaggca gccaacagaa cagaaagcgc 3039841 aaatccaatc attagtatcg ataactttga tttcatgttg agaagcacaa ctcctttacg 3039901 atctcttcca tattataacc tcgtttaagc gcgtttgaaa ccctcgccca gcacctcgct 3039961 cgcgtctgct acaattacaa aagctgactc atcaatctgt ttgacgattt gtttcaattt 3040021 ggtgaattca gtttgcccaa ccacgcacat taaaatcgga cggtcatcgt cagtatatcc 3040081 gccgactgca gaaatttttg tcacgcctct gtcaatcttc tgtaagacag cctccttgac 3040141 agcctgctcc tgctttgtaa tgatgagcgc catttttgaa cgattaaagc cgacttgcac 3040201 aacatcaatg gttttgctgg acacatagac gccaagcatg gcatataagc cttgctcaat 3040261 attaaataca atcatagccg taacaacgat cattccgtca atgatggcga gacacttccc 3040321 caatgacaga ccggagtact tatgaatgat ctgtgcagcc aaggctgtac ctcccgtcga 3040381 acctttccct aagtacacaa taccaattcc gatacctatc ccgacaccgc caaaaatcgc 3040441 cgccaggagt tcatgatgag tggcgggctg aatatccctt gtcagaaaca ctactagcgg 3040501 caaaaacaca gaacctgcaa gcgtctttag tccaaatttc ccgccgagca aaatgacgcc 3040561 agcaataaat aaagggatat taataatcca ctgtacatac gctgcttcaa aaccatatga 3040621 ttgtaaaatc gtactgatcc cgctgacccc gccggcggca atcttattcg gaagcaaaaa 3040681 tacattaaag gacacggccg taatcgctgc tcctatcaat atgtatacat aatcccgcaa 3040741 aatccacaat gttttattcc gtacgtccat catatatcct ccgtttcttc caatgctctc 3040801 cgatagcatt ttaatccttc cctgattaga tgtaaataac acccaaatac agtggtaata 3040861 tgctaaagca gcagtgaaat caaggatata agaaataaaa aaacacaccc gtatgcatca 3040921 ggtgtgtttt tcagcttatg aaagcttaga acgcaggtag gcatcaataa acgtatcaat 3040981 gtcaccatcc attacagctt gaacgttccc catttctgta ttggtccgat ggtcttttac 3041041 catggaatac ggatggaata cataagaacg gatttggctg ccccagccga tttctttttg 3041101 ttcaccgcga atttcatcca gctctgcctg ctgctcttca attctgcgct gatacagctt 3041161 ggccttcagc attttcatgg ctctttcacg gtttttaatt tgtgagcgct ccgtttggca 3041221 tgtcacaact acgttcgtcg gcaagtgagt aatccgaacg gctgaatccg tcgtattgac 3041281 gtgctgtccg cccgcgccgc ttgcacggta cgtgtcaact ttaatatcct ccgtacgaat 3041341 atcaatatca atttcatcgt taaattcagg catgacttca catgaaacga aagatgtgtg 3041401 gcggcggcct gatgaatcaa atggtgagat ccgcacaaga cgatgaacac ctttttctgc 3041461 tttgagatac ccgtaagcgt tgtgtccttt gatgagcaat gtcactgact tgattcccgc 3041521 ctcgtcacct ggaaggtaat cgagagtctc tactttaaag ccgcggcgct ctccccatct 3041581 tgtatacatt ctaagaagca tagagcccca gtcctgtgac tctgtaccgc cagcaccagg 3041641 gtgcagttct aaaatcgcgt tatttttatc atacggctcg ctgagaagaa gctgaagctc 3041701 aaactcattg aactcttttg ttaatgactt tagttctttt tcaagctcaa gctggagatc 3041761 agtgtccggc tcttctttca aaagatcatg agtcatttgt aattcttcgt gggattcatt 3041821 caatttttta tacgaattga cataatcctt taaaccgttt gcttcattta taaccgtttg 3041881 agctttttgc tgatcattcc agaattccgg atcagccatt tgttcatcta gctcagcaat 3041941 gcgggcctcc tttgattcga ggtcaaagag accccctaaa gtccgctaaa cgagaagcca 3042001 tattttcgag ctctgctcta atttctgata attccatttc attcacctca ttaaaagatc 3042061 cgcaggcgcc tgcaggcgcc gcggtcagta aacttgccgg ggcgaactat tcagtacggc 3042121 cgcagcaatt tttatatttt ttcccgcttc cgcagtggca tggggcattt cgtccgatat 3042181 caaccacttt gcgaaccggt gctttctttg cttttttgtt atcgtcgcct tcttgcggct 3042241 gatgagctgt tgtttgacct tgtacaacct cttcacgctc cagattgttt tcaatctcag 3042301 ctttcatcac aaattttgcg acttcgtcct caattgattc aatcatatgc tcaaacatcg 3042361 caaaaccttc catttgatac tcacgaagcg ggttcgtctg cgcgtaagca cgaaggtgaa 3042421 tcccttggcg gagctgatcc atcgcatcaa tatgatccat ccatttagaa tcaacggcac 3042481 gaagaacgat aactttttcg aattcgcgca tttgctcttt gccgaattgc tcttccttct 3042541 cattatattt tgtgatgatg cgatccataa tgagctcaag catttcatcc ggttctttgc 3042601 cgaagatatc gctcttctca agtgcacctt catcaagata agttgtgttg ataagatcaa 3042661 ctagaccgtc aagcttccac tcctcaggaa gctcttctct tggcgtatag gctgcaattg 3042721 cgcgttcgag agaagacttg atcatatttt caacgatttc acgcaggttt tcagagtcaa 3042781 tgacttcaaa gcgctgctta taaatgacct cacgctgctg gcggagaaca tcatcatatt 3042841 gcagaagctg tttacgcgaa tcgaagttat tgccttcgac gcgtttttga gacgattcaa 3042901 ccgcgcgaga taccattttg ctttggattg gagtagagtc gtccatgccg aagcggtcaa 3042961 gcatcgccat tgtccgctca gctccgaatc tgcgcatcaa ttcatcttcc atagaaagat 3043021 aaaattgagt aatccccggg tctccctgac gtccggaacg acctcgaagc tgattgtcaa 3043081 tccggcgtga ttcatgtcgt tctgttccga ctacagcgag cccgccaagc tcttttacac 3043141 cttcgccaag cttaatgtcc gttccgcgcc ccgccatgtt agtcgcaatc gtaactgcgc 3043201 ctttttggcc ggcctcttca atgatctgcg cttcacgttc atggtttttg gcatttaaca 3043261 cttgatgcgg aattcctttg tttttaagca gcttagaaat caattcagat gtttcaacgg 3043321 caaccgtacc gactagaaca ggctgtcccg tcatgtaacg ctgtgcgaca tcctccgcaa 3043381 ctgccttaaa ctttccttcc atcgtgcggt aaattaaatc cgggcggtca tcacggacaa 3043441 caggcctgtt ggtagggatc gtgacaacct gcatgttgta gatgttgcgg aattcttctt 3043501 cctctgtctt agctgtaccc gtcataccgg caagtttttc gtacattcgg aagtagtttt 3043561 ggaacgtaat cgtcgccaag gtcatgcttt cgttttgaat ctcaagccct tcctttgctt 3043621 caatcgcttg gtgaagcccc tcactgtagc ggcggccttt catcagacgt cccgtgaagg 3043681 aatcaacaat aacaacctgt ccgtcttcca ctacatagtc aacgtccttt tgcatcgcaa 3043741 cgtgagcttt taaggcctgg ttgatatggt ggttgagcgc gacatgcttc acatcaaaga 3043801 ggttatcgat gccgaatgct ttttccgcct tcgtcattcc ttcttcagta agctgtacag 3043861 cttttgtttt gatatcgtac gtgtaatcct tctccgcttt taacgtgcgg acaaaagcat 3043921 ttgcctgtac gtacagctta gtggattttg cagcttgtcc agaaatgata agcggtgttc 3043981 ttgcttcatc aattaaaata gagtcaactt catctattac cgcaaaatga agcgggcgct 3044041 gaaccatctg ctctttataa agaaccatat tgtcacgcaa atagtcgaag ccaagctcgt 3044101 tgtttgtgga gtaagtaata tcagcggcat aagcttcccg tttttcgtct tttgacattg 3044161 agtttaaatt caaaccgaca gtcaaaccga gaaactcgaa aattttcccc atttgctcag 3044221 cgtcacggct tgccaagtat tcgttgacag tcacgacgtg tacgccttta ccggttaacg 3044281 catttaaata aacaggcagg gtagacgtta atgttttccc ttcccctgtt ttcatttccg 3044341 ctatatttcc gtcatgaagc gccacgcccc ccatgagctg gactttaaac ggaaacatgc 3044401 ctgttacgcg gcgtgaagct tctcgaacaa cagcgaaagc ttcaacaaga agatcatccg 3044461 ttgtcgcccc tttttcaaga cgctctttaa attcaattgt tttatgtttc aatgcgtcgt 3044521 cagagagatt ttcatagtct ccgcgaatcg catcaatatc gttagcaatt ttttcgtatc 3044581 tattcagcgt acgttttgtt ggatcaaaca ttttatttaa aattccaagc atttataacg 3044641 ctcctctatc atcacacgcc tattttagag gcatgtataa ataatttact agtccatgta 3044701 tacctctcat tatcatatca taccttttgt tatttccaaa gaatttgcaa ataagaaaaa 3044761 caaaaacctt ccgcggacat cacggaaggc ttctcttcat tattcagtcg gttcaattaa 3044821 gccatatttc ccgtcatttc tgcggtacac gacatttgta aggtttgttt ccgcatttgt 3044881 gaaaacaaag aaattatggc cgagcatatt catttgcaag atcgcttctt cactatccat 3044941 cggctttaaa ttaaagcgtt tctgacggac gatgtccaag ctctcctcct cttctatgtc 3045001 atcctgaacc gcaatatctg tatcagagcc aagaccgttt gccaataaat attttggaga 3045061 gccctgctca cggaatttac ggtttacttt cgttttatgc ttacggattt gacgttccag 3045121 tttgtttgtt gcgagatcaa ttgcgttgta catatcctcg ttatgcacct cggaccgaag 3045181 cgccagatct gtcatcggaa tcgtaacctc aaccttagac tccttgtcat tgtaaaactt 3045241 caagttgacg ttcacatcag catccacgct atggtcaaaa tagcgctcca gcttgccgat 3045301 cttcctctcg acatgatcct ttaacgcggg tgtcacttca atattttctc ctctgatgtt 3045361 atagttcatc aaagaacgcc tcccttttat taaggatatg tatctatttc tcttttaccc 3045421 tttacaattc ctgctgaaac ataaatcttt tgtgaaaatt cagtgaactt tgtcgaattt 3045481 tgtttgtatt tgctctgtta ttggcggctg ctaagctttt gaatcaaaca gtttcatttt 3045541 gctacttttc ggcagctcag ctttaattga tttgctgtaa ttgaagttat tttccttagg 3045601 aaccagcata tcgtacgaaa tagagatgaa ttgcagcgcg tctcttgtca gctgcctatt 3045661 catctcattt acttttttca gacgtccgag aacttgagaa agagattcgt atagttgttc 3045721 cagctcttcc ttttcactgc ctgaggtttt ggcgatacat gcggaaatag tattattttc 3045781 gctatatccg agaaaggccg aagttgtttt gatccggtca tcttctgtct gcgtgattgc 3045841 ttgaatatat ttttgctctt ttgtcaaaat gttagaaagc tcttttgttt tgccggcttt 3045901 gagcgcttcc gtcttttctt cagacagcgt gagcaggtgc tcatgcagaa cgcaaagtcg 3045961 cttcaattgt tcaataattg ccttcgctga catgggcttt ctcctttttt attgcttttt 3046021 ataaaaatta atcatatttt tcgcaatatg atttgcgtct actttgtatg acccgttttc 3046081 aatttgcgct ttaagctgcg caattttttc ctgtcgtgaa ccagtgactg cgtcggatgc 3046141 atgttgcatt tctttagcct gtgatgaaat ttcaatttta tcttgaggtt gtgcaacagt 3046201 tttttgcacc gcttgcttat cataattttt ttgatatgga ttaacggatt gtgttccaaa 3046261 ttgattgatt ttcataggat tcctctcgct ttccgttgca gtctttaaac aatcttaacc 3046321 cttttatcga ctgcgttttc agttagttta gggaatcagc tgtttttggt attataggca 3046381 tagtatgtgt cttttttact attttctttc tcgattttca gagcatcctc gtggttcaaa 3046441 tgatccattt gatccttaat atcagactgg caagccttgc agaacttgcc ttctctaatc 3046501 gatgtcccgc acctttcaca agggtatgcc aaattaggaa gatgagtgat ctgaattcgc 3046561 ttctgcctga tgaatttcaa tatcagctct tcttccacac ctgtttcctc agttatccgg 3046621 ctcaaagttg attgccggtt ttcctgtttt cttaaaaatt tatagacagt ctcaaatgat 3046681 ttttcttctt ccttaataca cgcctgacat acggtttgca gctttgtttt taaaaataaa 3046741 gcattgcatt tcggacaatt agccagttct cccatctttt tttctcctta ttagataata 3046801 tgcctgtgtc aatttctagt gattatatcg gcataaaaac agaatcattt agcttctgat 3046861 caaggtaaaa gatgacactg aagcggcttt tcctttttct aataagcagc gggctgcgaa 3046921 gtgcaaggtg gcgcctgttg tataaagatc gtctattaaa atgatattca taccttctgc 3046981 tgaattattt tttgtatcaa aaatgcactc tgacagcagg cgttctgttt tctttttctt 3047041 tgactgtttc tcattattca ggcgaatgag gggatggtgg gaaggccggt ctaaacattc 3047101 tgccaagaga tgtgcctggt taaatccgcg ctcttcttcc cgttccttgc tcagcggaat 3047161 aggtacaaga acaaaatgct tatcggggta aaccttagaa aaggttgaag aaaaatcact 3047221 tttaaatgca tttatgattt ctgcatctcc tctaaattta aaacgggaga gcgtttcttt 3047281 catcatatca ttatatgtgt aaactgaacg gttttgacgc aatagcaaac tgtctctgat 3047341 ccttgttctc cacacctcgc aatccctgca tacggcatga acagattgag gtctgccgca 3047401 cagggggcag atatgtcctg tgattttctt taatttgctt ctgcaagaat aacaaacctt 3047461 ttcatcaggc tttagtaaaa aaagggctct ccatgtaaca tcttgagaaa attgcgaatc 3047521 acataataaa cagatcagtt tatgaatgcc tcctcctgct tcgtttgaca taaatcgctt 3047581 ggactctctg aaactactgc agcagattca gccaaaatga caagcattgc tgtgtttttt 3047641 tgtttatcta ccagctcagc tttcgtatat gcgatctttt taaaatcagt aacgtaggat 3047701 ggactcactt tgtttaaaga aagtgccaat acatcgtttt ggcatacttg gcaagtacag 3047761 gccatatgaa gctggtccat atatcggtcg agcagttctt tcattacgat ttcttttgaa 3047821 ttgacaagca tttttacagc tcctcatcat cggttatatg agtatactgt accacgtttt 3047881 caaataatgg ctagtctgta cattcaactt ttgctgccaa ttcattcatt tcttttatat 3047941 gctttcttgc atcgagcata ctctttgttt tgccgaagtg aaagtaaatg acatcgccgt 3048001 ccgcatattc tttatgccgg ccggttcttc ctgcaatttg aacaagtgcg ctttccgtaa 3048061 agatagacga ttccgctcct agtacacccg tttgcacctt ggggactgtg acgcctcttt 3048121 ccagtattgt tgttgtgatt aatagatcga gctgaccatc tctgaattgc tgcactttct 3048181 cctttctatg cttgtcttcc gcgtgcacag atgcggttcg gcaatgaaca cctttaaagc 3048241 acgcagcagc cttttccaga atagaaacgg aaggaacgaa taaaaaaaca ggcctccctt 3048301 cttttacatg aaactctatc catcttttca ccgctggcgg aattttattt cggtttaatt 3048361 tcttcttcca gtttccacac catacaaagc gcggttcggg taaaggtttc cggtggtgtc 3048421 ttgcggggat gcgaactgaa tgtaactgtc cgttcagtgc ttttcttttt aattctttag 3048481 gaggtgttgc acttaaataa acgagggtgc tgtttttctt tcttgctttt tgaacagcga 3048541 attgaagggt ttgatcagca gaatatggaa aagcgtcaac ttcatcaatg atcataacat 3048601 cgattgcatc tttatatcgc aaaagctgat gcgtagtgga aatcataagc ggagatagcc 3048661 gccctttgtc atcgcttcct ccgtaaagcg ctgaaatgtc agcaccctga aaggcagcct 3048721 tgagtcttgg agcaagctct aatacaacat cggtgcgagg tgttgcaata catacacgca 3048781 gtccttgatt taacgctgat tctataccag gaaacagcat ttctgttttg ccagcgccgc 3048841 aaaccgccca gatgaggagc tcttcttttt ttgatattgc ttcaattaaa acattggcgg 3048901 ctttttgctg tccgcttgaa agcttgccat cccatgtcag cttaatagac ttccagtttg 3048961 attcattttc ctctttccat gaatataaag gaacctcctc actcactctg cccatcatga 3049021 cacaggaacg gcaatacagc ttattctttc cagatgagtg ataaaaagaa aaataccgct 3049081 gatcagtttg tccgcaccta ttacatctat atctccgttt atttatggat atagaatttt 3049141 cagcagtgat atatccattc ttgatatgcc attcaatcat ctcatcggaa aatgagagct 3049201 cagtcctgag caaatgacgg cttcgaagcg tctgctgcaa ttcttttgaa aaggaactgt 3049261 ttttttcaac tggcacattc acatagcacg cctcctttcg aaacagtatg cctgaatgaa 3049321 tattttctgt ccaactatta aaataagaat ataaaaaaat ctccgctcta aaaacggaga 3049381 tttggcctta tttaaaacac cagcaaattc ctaacgcacc ttcacccaaa tgagtgccga 3049441 ttaccgcgcc aaaatagctg ttataaaatt caacatgagg atattttgca gaaagctctt 3049501 caatgatttt cgctgcttct tcctctcgat tagcgtggat aacagcagct cgcataggca 3049561 accctttact cgcatcttcg tctaaaagct cataaattcg cgaaattgct tttttacgtg 3049621 tgcgaatctt ctcaaaaggc acaattacct tattgtcaaa atgaaggata ggctttacct 3049681 ttagaagact accaatgaag gcttgggcgc tgcttaatcg cccgccgcgc tgaagatggg 3049741 ctaagtcatc taccataaaa taagctcgaa ctgttttttt catttcttcc agttctttta 3049801 taatatcttc cggcgatgat gctccgtttt tgattaattc agcagcttta agggcataaa 3049861 agccttgagc caagcagctg atctctgagt caaatggata cacatcaata ttgtcgacca 3049921 tcgaatcagc cgctgctgca ctgctgaatg ttccgctgat cccgctggaa agatggatac 3049981 tgataaccgc atcataagac ttgccaagct cttcatacaa cgcaaccagc tcgccgattg 3050041 gcggctgaga agtcgtcggg agctcattat gttttttcac ttcttcataa aagcttttcc 3050101 agtccaactc aatttcttca cggtaagtct cctccctaaa aacaacctgg agagggatca 3050161 tatgtatctg atgttgttca cgcatttctt tcggaatata tgccgtgctg tctgttacga 3050221 ctgcaatatt catagcttcg atacctgcct tattgcttta taactctatt gtaagggaaa 3050281 cggcagccta aaaaaagacc tgcctagtaa aaggcaagtc tcctattata ctatctcatt 3050341 tctacccagc catttttaat ggcgaccaca acggcttgcg tccggtcgtt tacattcatt 3050401 ttttgtaaaa tattgctgac atggttttta acggttttct cactgataaa caatgattca 3050461 ccaataccgc ggttgctttt tccgtctgca agcatctgca gcacttcaca ttcccgccta 3050521 gttaaaatat gtaatggtct gcggatttca gggtaaacct catgttgagg gtgtgcagaa 3050581 actccgcttg ttgcaaggcg gcggaattcg ttaacgaggt tgtgagtaac cttcggatgg 3050641 aggtaagatc cgccctcagc cactacttta accgcttcaa ttaatgtatc agcatccatc 3050701 tctttcagca gataacctct tgcacctgtt ttcagggcat gtgttacata attttcgtca 3050761 tcgtgaattg atagaataat tactttagat tcaggataca gctctacaag ctgttttgta 3050821 gcttccacac catttacgtt tggcatattg atatccatga tcacaacatc aggatgatag 3050881 tgctcaacaa tacgagccgc ttcgtccccg tcatcacctt cggctaccac ttcaaaggta 3050941 ggttcaaaat ccaatatccg tttaacacct tcacgaaata actgatggtc gtcgataata 3051001 acaatgttta ctttagtcac aagccacgcc tccttgtatt attgttctat atactctagc 3051061 attcggtcaa tatgcctttt ggctctattt tacaaatcat agtcaaagag ataacggaac 3051121 cttaatcata ataaatgtcc caagacctat tttcgaatct attgtcatcg ttccttccaa 3051181 taaatctact ctttctttca tgcccagcaa gccgaatgat ttgtttttct tctctttcgc 3051241 ttccttcagg tcgaaccctt taccgttatc ttttatcatt aaaatcacaa aatcctttgt 3051301 gatctcaact ttgactgtaa tttcttcaga ttcagaatgc tttagcgcat tagacacagc 3051361 ttcctgtgcg agcctgaaga gcgcaacctc aaactgaggc gctagcctct gatcctctgt 3051421 ttctccaatg cactgaaaat gtattttgac cttcccgtta tattcctcgg ttgtatatag 3051481 atattttctt aaagttggaa tcaggcctag gtcatcaagg gccatcggtc ttaaatcata 3051541 tataatcctt ctcacttcgt aaagggcatt ccgaacattt tggcggagat ttttaatttc 3051601 ttggaatccg tcctctgcgc cccggtcacg gaaaatccgc tcgattaatt ccgatctcat 3051661 cataacattc gccagcattt gagcgggtcc gtcatggatt tctcttgaga ctctttttcg 3051721 ctcttcttcc tgcgcctcaa taattcttaa gccgaaatcc tgttttgcct gagcatcagc 3051781 aagaagcagt ccaacttcgc gcaaatcctg attcaagtag ttgagcacaa ctgtaatttg 3051841 gcttactaat gattctgacc gctcaatgat ttcctgaagc cctagcaatc tgcgctccaa 3051901 atcgtcccgc cgttcgcgca attgcttctc acgctgctgg atcatcgtca attctacctg 3051961 cagcttatgg gctttttcat aagcattgcg gatttcctct tcactgaatc tatgaaaatt 3052021 acggctgacc tcggataaac ggtttctcgc atggcgagtt tgcacttcaa gtttatcgcc 3052081 aagctcaatc acttcataca cctgctgttt aatttgtttc agttcttcga ccagctgttc 3052141 atactgctgg cgtgactgct ccccgatttg aaaaacctcg tccttgctcc cgtcaacggt 3052201 tttcagcatc ttcatcaaaa tagaatccag cactttggaa tccatctttg ttttattcat 3052261 aatttccctc cgtcacggcg ttgtcatata tttttattat aaatgtaatt gatctgcaaa 3052321 ttatgtcgaa ttataatgaa agaatgcgta tattctagaa aaaaacattt ttatatacta 3052381 tctactcttt atgataccaa aatacgcaca aaaattctaa agactgtacg aatttgtata 3052441 ggcagtcttt tatgcttagc aggagggtca gctagcatgc tgcacagcta ttttactgtg 3052501 aaagaagcgg gagaacacga gattgttata gaaaaatcgc gttttatctg tcatttaagc 3052561 cgtgtttcta ccgaacaaga ggcacaggaa tttatacaga aaataaagaa acagcactgg 3052621 aatgcgactc ataattgctc ggcttatgtt attggcgaga atgatcatat ccaaaaagcc 3052681 aatgatgacg gggaaccaag cggtacagcg ggagtgccga tgctcgaggt tttaaaaaaa 3052741 cgcaggctga aggatacttg cgccgtcgtt acacgctact tcggaggcat taagcttggt 3052801 gctggcggat taattcgcgc ttatgggaaa tcagtgtctg aaggattaaa tcatataggt 3052861 gttgtagaac ggaagcttat gcgaatcatg catacttctg cagattacac atggcttggc 3052921 aagattgaaa atgaattaag ggagtcacaa tttctgttaa aggaaatcca ttattcagaa 3052981 aatgttgaat tcgaaacata cgtggaagaa aaagaaacca acgctttttc tgaatggatg 3053041 acagaactga caaatggaaa gagtgatatt aaagagggag agttgacgta tcttgaaaaa 3053101 gccgtcaatc acataaagga gactgaataa tggctgaacg cgttagagtg cgtgtgcgaa 3053161 aaaagaaaaa gagcaaacgt aggaaaattt taaaaagaat aatgttattg ttcgcccttg 3053221 cactattggt agttgtaggg cttggcgggt ataaacttta taaaaccatt aacgctgcgg 3053281 atgaatcgta cgatgcccta tcccgcggga ataaatcaaa tcttcgcaac gaagttgtag 3053341 acatgaagaa aaaaccattt tctattttat ttatgggaat agaggattac gcgactaaag 3053401 gacaaaaagg gagatcagac tctcttattg ttgttaccct ggatcccaaa aataaaacca 3053461 tgaaaatgct gagcattccg cgtgacacac gtgtgcaatt agctggtgac acaacgggaa 3053521 gcaagacgaa gatcaatgcc gcttacagca aaggcggtaa agatgaaaca gttgaaactg 3053581 ttgaaaactt cttgcaaatc ccgatcgata aatatgtcac agttgatttt gacggattta 3053641 aagatgtgat taatgaagtc ggcggtattg atgttgacgt gcctttcgat ttcgatgaaa 3053701 aaagtgatgt agacgaaagc aaacggattt acttcaaaaa aggcgagatg catttgaacg 3053761 gcgaagaagc cttagcatat gcccggatga gaaaacagga taaacgcgga gactttggcc 3053821 gtaatgacag acaaaaacaa atcttaaacg cgctgattga ccgcatgtca agtgcaagca 3053881 acattgctaa aattgataaa atcgcagaaa aagccagcga aaacgttgaa accaatattc 3053941 gcattactga aggtttagcg cttcagcaga tttacagcgg ctttaccagc aaaaaaatcg 3054001 acacattgag cattacaggt tctgatttgt atttagggcc taacaacaca tattactttg 3054061 aacctgatgc tacaaatctc gagaaagtca gaaaaacgct tcaagagcat ttagattata 3054121 ctcctgatac aagcactggc acttccggta ccgaagacgg gactgacagc tcaagcagtt 3054181 ctggcagcac tggcagcact ggcacaacaa ctgacgggac gacgaacgga agcagctatt 3054241 cgaatgacag cagcacaagc tcaaacaaca gtacaacgaa ttcaacaact gattcatcct 3054301 attaaaaaat gcccggtcct tttagaggat cgggcatttt tgcgcagaaa aaaactccgg 3054361 cacataagcc ggagttttta attccttttc accagccgtt tataaaactt tgtaaacggc 3054421 ttaaattttt cattcacgag tcctgtcact tctgctatga tttgcataaa aataatcaaa 3054481 atgaagataa taaacaaaga aagccaaatt gtggcacttt taagtacaat cgcactgata 3054541 ctgaaaataa atccaattaa ataaataact aagaccgaca tccgatgtga aaggccaaag 3054601 gccatcagtc tatggtgaat atgcgactta tcaggcgctg aaatcggctg tttgtttaat 3054661 attcttctga tgatagcaaa tgttgtatca aaaatcggta cgcctaatat aataatcggg 3054721 ataacgatac tgaacaatgt gacactttta tacaggccta ataatgaaag aatcgagata 3054781 ctatacccta aaaacagtga tcccgtatct cccataaaga tttttgccgg atggaagttg 3054841 taaaacaaaa accccagcgt gctggcaata acgactaatg agagtgacag aatgagcact 3054901 tttccgccgg atagcgccat gacagcaatc gttgacaggc cgataacaga aagaccggca 3054961 gcaaggccat ccaatccatc aatcaggtta attgcgttcg tgatgccgac aatccataat 3055021 accgtcagcg gataagccat ccatcctaac tcaaatcgtt ctgttaaaaa aggtactgag 3055081 aaaaagtcca tttttaagcc agtgcttaca atcataatgg ctacacctaa ttgaatcaaa 3055141 aacttaactt ttgcacttaa ttgatattta tcgtcaagaa tacctaacac aataatgatg 3055201 aatgctccga ctgtaattgc cgtcatcctt gtttctgtgt aaataccgga tgcaagcacg 3055261 cctgcaacca ccccgataaa tatggccagc ccgcccatgc ggggcatgat tttgtcatgt 3055321 acttttcgat tgctgggctg gtcaactgca cctattttaa tcgcaatcct ttttacgatt 3055381 ggggttatga ttaaaactgt cagcagcgag acaataaacg caacaacaat gcgaatcatg 3055441 cgttcgtcaa gcataaagaa gtctcctttg gaattaaatg aagtctttat ttatatagag 3055501 aaccgttcct tccattatac cttctcctta gttattataa caagcttcat caaaaagaaa 3055561 cacgtataat caaaaaacgc gcatcccaat ttataggact acgcatgttt ttgaatccct 3055621 gtatatttca taatttgtct aaataagcaa ttccaatctt gtgtccgggc gatgtttcgg 3055681 cgcatttctt tataggtctc gtctccgttt tgaccgagaa ctttttcaca agcggctata 3055741 aaatcaatcg gatgatcgcc ctctacatat tcgtatacat acggcttttg catttttgag 3055801 gttgacggaa gattagtgcc tacaacaggt tttcctgccg ctaaaaattc aaatagtttc 3055861 agcggaaaca cagcttgatt atacggtgat tgtttatatg gcataatgcc aatgtcgata 3055921 agctccatat aatgaggcac ttcttttgga tctgccggac cggtccatat gacattggga 3055981 agcctcagca gctcttgaaa cgaaacatca ccattggtgg catccgggcc aacccataaa 3056041 aatgtccaat caggcttttg cagtgccgct tctttaatca ttttaaaatc gagcttcggt 3056101 ttaatcccgc caataaaacc taacactatt ccttctctcc cctgcagtat actgcgatcg 3056161 ggagcttgtt tatttgcaga aaacagctca tactccacac cgttttccac agtatgaacc 3056221 ttttctcgtc ctgcagtcag ttttttgtct acttccttgt gaagataatc tgatgaacag 3056281 gttattgaat ctgctcgttg tataattctc agctctgccg atttaatgac ttttcgccgg 3056341 aattcagaca gcagatttga tcggccgctg atcggcgcag cccataggtc actgcagtca 3056401 taaatgacct gatcccaaga atacagcgaa gacagcagcg ggaatccggg aaacgtgtac 3056461 cataaacagc agcgttcacc gtttgcagaa gcaggtgtaa gctcatcgag taatggggag 3056521 agcttatgtc tgtaaaagac atctgtatat cgtccgaaac gaaacatttt tttctgcagc 3056581 aggtctttga cagcgaattg cctgatgcca gaatggactt cctgaaactc tttcccttgg 3056641 gcacgcggag ccggacatac ccaaataact tccttcgttt cctcctgagc agctaaaaat 3056701 tctgccagcc ggtgccttct gtatctcaat tggtcttttc cccattcagc agtggcaacg 3056761 atgacatgaa tgattgcttc ttttgtttcc accttcatca ccttttctct ctgtttgcag 3056821 ctataatctt tttttcaccg cgttttttgc atattgaaca aaacaccatg ttgctttcat 3056881 aaaatgaagc cgttcgatct ccctgtagac aaaccacgtt tttttcgcag ccttccattt 3056941 gttgctggaa attgaattat tgacaagccg atattcagcc aggcattcat tcattccata 3057001 ggcagtaaat ccttttttta aaagagacag ccatgtggct aagtcctgtc tcgttctgat 3057061 attcggcatt tggatctgtc ccgtttgctc cctgtcaatc atcaccgtca agcagccgat 3057121 aattgtattt ttcagggcgt catcgtacgt caggctttcc ggcgcatgaa taaatttatc 3057181 gagcggggtc ccgtcctgcg ccattaagct gtagcccgtg aaagagaacg cacaggagcg 3057241 ctccatcata aactcaagct gcttttccag tttgtctttt ttccatttgt catcactgtc 3057301 caaaaatgct acgtagcgcc cttgagcgcg ttccaacgct ttgttgcgag caaccgcagc 3057361 tccggagttc tcttccagat acaccacatg aattctttcg tctatttttt catactgctg 3057421 taaaatgtcg cgggtcccat ccgttgagca atcatccacg ataatcattt cccaatgagg 3057481 atggctctga tctaataccg aatgaaccgt gtcttcaata tagtcacgcg cattatagga 3057541 aggtgtaatg acagatacga gaggtttcca attggtcatg atcacatctc catcgtatga 3057601 ttttaaaagg attctctgaa aaattcagga atgacaacga acataaaggc aatcgtaagg 3057661 ccaatcataa cgccgagaac tgctttcttt ttcggagaca taccgccgcc tgctgtctca 3057721 cttacggttt cggaatcagt aacacttgcc gctttcaggt taagctgtgt gtttttgagt 3057781 tcatataaaa atctctcttt atccactttg gaatcctcgc tcaccgactc gccttcaagc 3057841 gcgtctatgc tgctgcggat gacggcttct ctttctgcat acagcttttg atcgtttttg 3057901 aggaaggtgg aggatatggc gtttaagaca gattccgttc tatccttatc ctcgtcacta 3057961 tagcttaaag tcagtaacga tttggattcc gtattgattg taagcttctc tttgatctct 3058021 gctacatctt catccttttc atcaggaagc gcctccttca aaaaggagtc gctctttaat 3058081 agaagcggaa tctcttctgt gctgttataa accggatgat catagctccc cacagccaaa 3058141 gtatcttcag ctgtatagct cttttgatca gcgatctgtg acggcaggat ataccccgcc 3058201 gcacctaata taattggcac cgctatgatc caaatgatat ttttttttat gcgacgggct 3058261 attcttatca atatatcgtt catataagtc tccctgcttt ttgtagtctg tttatctgta 3058321 catcggctca ggcatttgtc tggatcgcct taacacattc acggcggcga tgacgagcgc 3058381 cataaacacc caatggaaaa ataaatttga aacagagctt gggctgatac ttgataccag 3058441 gaaactgacc atagcggtaa taagtccttc tgtgatcagt tttgactgat tttctaattt 3058501 tctttcataa aacttgtaaa gcacccatat gaggtaggca taaacggaca aatatcccag 3058561 catgatgaac aaaccaaaat tagcaagaat ttcaacaagc cagttatgca cctctgccac 3058621 attgtcagta tcatatacag cataatgctc aagataatag gatacatttc ctgccccgac 3058681 tccgaatccg tatgaatcaa ggaaaaaatg ccaagcgttt ttcagcagat ttgcccgagc 3058741 cacatttgat ggaagcctgt catgaaatga atgcagcgtc tgcggggcca gaaacagctc 3058801 ccaaaacttt gaatagattt tgctggcgaa aagaactgcg aaaagagcaa ttcccgccgc 3058861 cgacagccat atagccattc tctttaaaac aggcggcaat acaatgaaga tgtagacagc 3058921 aatacctgca aaaatgccca gaaggctggc tcttgaacca gtggcaaaaa ttaaatacaa 3058981 cgcacagagc gagagcacaa ggccaattgc cttgatgtat ccattcttaa tgtttttcat 3059041 catcgtgatg taaaaaaaga agctgatgga taaaaaggtc gcaaagtcat tttgattaaa 3059101 aaagaccgat gtcggataat gctgcttgta ctccggtccg ctgtacaatg tggaactcgc 3059161 aagatgatgg tgggtgatat gattgtaaaa accaatgatc atcagaaata ccgtcatcac 3059221 cagccaaatg gcataaacaa tcatcagccg ctccattttt tgcacgtaca tgacaataag 3059281 ataaatgaag aagatcccca ttgccaataa ggctaaatac ttgaggccaa ctgttaccga 3059341 cttggcccac agcagagaaa caaggccata tataaaccaa aaggcgaaaa agagtaaaat 3059401 cccttttact tgcagcccat gccatctttc aatatgggtt cgattccgaa ccatgccgaa 3059461 aatatgaagg caacccgctg caatgagcag aagccggtaa aggaacaaac tgaaaaatcc 3059521 aagatgaatg gcaaaaaatg cattatttaa aaaagtgcag gcgatcaaaa tatagattac 3059581 agccataaag agccgttctt ttgttgtaaa tgcggttgca agcgtcagta aaaacaggcc 3059641 aattgccaac accgcaagca cagcagccat ctgcatgaaa cctatatctt tatggatggc 3059701 tcccagcaat aggacgactc caaatatagc agcggccagt aacgctagcg tatggaccgc 3059761 tgatcgtttg atactcacat gtttaacccc tttcctgatg tttcaggagc cggcggccga 3059821 gcctagcagc cggcagcttc aaccaagtaa cactttttct ttttataaat tgacgcttcc 3059881 caagtcttta gccaattctt caagcggcaa gcccggaaaa tacttgtcag agggttccgt 3059941 tccccgaaca gcgggacggc cgatagagtg ataaatgtat ccggctgcct gcatctcttc 3060001 aagtgaaaat aaatttctgc cgtcaatgat gactggctgt tttaagaggg ttttcacttt 3060061 tacaagctcc atttctttca cttccggcca atccgttaaa atcaggcatg catcagtgtc 3060121 ttccatcgca gcatacacat ctgtgtaata ctcgacctgt tcgccaagga tcgctgaagc 3060181 ttcaggaata gcaatcggat cgtatgcttt tacatgggcg cccagctgct gcagcattgg 3060241 gataatatca agcgctggag cggatctcac atcgttcgta ttcggtttga aggctaatcc 3060301 caggactgaa atggttctcc ctttgacgct tcccataaca gtcaaaagtt tatctacaat 3060361 atgaacacgc tgcttttcgt tcgtttcaat gacagcttcg atgagcttga atggatagcc 3060421 tgccgatttt gcgatttgaa gcagcgcggt tgtatccttt ggaaaacatg aaccgccgaa 3060481 tccaatacca gctttaagga actttctgcc gatacggctg tcaagaccaa caccatcagc 3060541 aacttttgaa acgtctgcgc cgactcgctc acaaatgttt gcgatatcgt tgataaagga 3060601 aatctttgtc gccagaaatg cattcgcggc gtatttaatc atttctgcac tttctaggtt 3060661 tgttttaatg acaggagcat ggaatggctg atgaagttcc tcaatgatgg cagcggcttt 3060721 atgacttgtt gaaccaatca cggcacgctc catattcatc gtgtcatgaa tcgctgaccc 3060781 ttcccgaagg aattcagggt tagatacaac atcaaatgag tatctcccct ttgaggcttt 3060841 ttgaacgata gattgcacca gtttccctgt tccaaccggg actgtgcttt tatttacgat 3060901 cactttgtag ccgttaagat gctcaccgat tgttttcgcc gccgctttga cgtacgttaa 3060961 atcagcttca cctgttttgg acataggcgt tccgactgca atataaataa tatctgaggc 3061021 ccgaatggca gacgggatat cgttcgtaaa ggtcaggcgc tgatccagca catttttttc 3061081 aactaagtct gcaagccctg gttcatagat tgggattacc ccatttttca ggcttctgat 3061141 ttttgattca tcgatatcac agcaaacaac tttattgccg atctccgcaa agcaagtgcc 3061201 tgatacgagt cctacataac ctgttccaat gacagctatt tttttcacag cgctcaaccc 3061261 tctcctgtaa aatgatcttc caatttataa tggtcgcagt gtcttacgat taaacggacg 3061321 ttttcgtgac cgtctgatac tgatgatgca aggccttggc gttttttcct gcgtcaaatt 3061381 gagcctgcac ggtttcatac aagtcatctg ctacttccgg cttccatatt tgctcatgtt 3061441 cgtaccgagt gatcgcttcc gccaaggctt gagcggattt cggtttaatc agcagatgtt 3061501 ggtgctttcc gaataaagac gacactccgc caacatccgt acaaataaca ggaaccctta 3061561 gcgccagcgc ctcaatcaca acagtcggca tcccctcact gtaagaagga agtacgaata 3061621 gatctgccgc aagtaaatag tctcttacct gatgattcgg gacttggcct gtgacgatat 3061681 gccccttctg cgtcagcgtc gattttgcgg gaccatcccc gacaaagact gccttaggag 3061741 agtcctgcag cgattcgatc gcttcagaca gttcaaaaat gcctttctct ctgaccagcc 3061801 ggccgacata gacagccaga cgctgatcga gcgggagtcc gagtcttttt ctgatttcct 3061861 ctttcgtctc ctcattcccc tgaaaacggc tgagctgtat gccgattggc aaaaccgagc 3061921 tgtcaaagcc cgaaagcttt ttggcttctt cctgaagctt gtggctgact gctaaaacaa 3061981 ctgacgcaga acctacggca cgcttgaagg ctttaaacgc acctttgctg taatgcggat 3062041 agacattcac atcactgcca tgcaaggtca ggacataagg aatttgcgct gactctgaca 3062101 cgactgccgc agccccgccc gatggcatgg caaaatgcgc atggatcaga tccggatata 3062161 ggtcgcgctg tttcattgtt tttaaaacgg ctgatgcgat tctccgatga ggctgcgccc 3062221 acttcagctg gccgggaact gcccgataga aaggccggta aaccggtatc ccctttctaa 3062281 tctcatactc cggtctgaca tccttttttc gatatgtctt tttcagcatg cggacaggtg 3062341 ctgaatgaaa aggccgtggg catatcacag tgatatcaag cccgagtttt tgcagctctt 3062401 gcacctgtgt ctcatgaaac acaccctctc cgggtttcat actgctcgga tatacgcttg 3062461 tgatccacaa aatcttcatg acaaacgtcc ttttcttagt agtttgcttt tcgtttgagg 3062521 gtacgctttt accaaaagaa agagatagca cagcgcccca gccgcaactg aaatggccag 3062581 ccgcatttct gcctgcatac tgaagtgttc ggtactgagg cttacaccaa acgcgatgat 3062641 gcccatcgcc gcagtaatca gaaatggctt cataatcgac tggaaataag ctgaaaggtt 3062701 aagcttgatg acatatgcca aaagccagcg cccaatcagg aaattaacaa cgctgataat 3062761 ggcatacacc catgcgactg tcagcaggct tcccgtctgt acagctgcaa acagtgataa 3062821 tccgtacagc agcagcacgc cggaatccca ataaaacgct aagtcagctc ttcctttagc 3062881 cagcaacaca gatccatttg gattcatgag cactcttagt attccgacaa tcgcaagaac 3062941 atttaggatc ggaacagcag caagccattt ttctccgaaa accgctgtga taaaggcgtc 3063001 tgacacagac acgagcccga ttaacagcgg aaacgaaaca agcgccagca tttttgtcat 3063061 attcagaaag ccttctctga tcacgctgtt ttcatatttg ttttttgcga aaatagggaa 3063121 tgccacccgt gtgacaatcg gattgatctt caaaaccgga atggtgacaa tctgataagc 3063181 gaggttataa atccccaatg cttcagcacc aataaaccgg ccgatcaaaa tcatgtcgat 3063241 atttgctccc agcctgttca caagacggga tgaaagctga aaggctccaa aagaaaagaa 3063301 atccttcatg cctctcaaat caaaaacaaa agcaggatgc cacttttttc ggtatacagc 3063361 ccaatataaa atccctttac tggactgcag caggacttga gaaatcacgt acgccaaaat 3063421 cgcatccatc ataaaaaccg ctatcgctaa atatccgaat gacaatacat ttgaaaaaat 3063481 ctctattttg cttaacgtat taaaatgcag ctgcttttgc agcatatact gatattgctg 3063541 tccaattggc gcgatcaaaa acataatcgc cagaatccga accagaaaca ccagctcttc 3063601 tctttgataa aatcccgcaa tgacaggact gctcacatat aaaagaacaa acagcaaaac 3063661 gcccgtcata atgttaagcc aatacaatgt tgacagctgg cgctccgtcg cgtcgtctct 3063721 ctgaattaat gctgcgccaa aacccatatc gagcacaatc tgggcgaaaa ctgtaaccgt 3063781 tgtgatcatg ccgacaagcc caaattctgt taaggtcatc atatttccaa gcagggcaaa 3063841 ctgaacaatt tgtatgattg taatacacat ggttgaaata cttgtccact ttgcaccgct 3063901 catgatttgt tttgtaatac ttggcatcat attccctact tctttttaag ctcagattga 3063961 tggtgaataa tggaatcccg ttttatcttg caccatcacc cgtccaaact actttacaag 3064021 tttttaacat aatttttaat tctaaagtga aagtcagatt gcgaatgtaa tataaatcaa 3064081 atatcagctt ttccttcggc gtcatatcgt aaccgccgtt cacctgagcc cagacgctgt 3064141 gtaaagcctg gaatctcatt ctggaatttt tccgtaaata cgggccgttc cggacgaggg 3064201 ccaatcatac tcatatcgcc tttcagcaca ttaaacagct gaggaagctc gtcaattctc 3064261 gttcttctga taaaagctcc gatccttgtc acccgcggat cttgcttctg tgcccaaacc 3064321 gccccagact tctcggcatc tattttcatg gaacgaagct tataaagctt aaatggcttc 3064381 ccgcctttcc ctacgcgttc ctgcgtataa atggcaggcc ccggcgtctc caaacaaatc 3064441 aaaattgaaa ataccgcaat cattggcagc gcaatcgcca atccaatgag cgcaaaccaa 3064501 atatccatta cgcgctttat tgccaaataa cgagccgtct tttcagataa tgtaaaagaa 3064561 tgtatttgtt gaactgagaa ttcacgactc acattcatgc ttttctctgc actcactgac 3064621 acacacctca cgatttgttt gggatgttat gatgacctat gccagtcagt ttagcagacg 3064681 gatgttaatt ggatgtaaat ggtatgttaa gaagtgtgaa ttacgtgttt tttctgataa 3064741 atgttgttaa tactctttta ctattttata tacaagtcct atttgtttta atcatttcat 3064801 ataaaaaaga gacaaatctg tgattagatt tgtctctttc gattatctgt aataagatac 3064861 tgtgccgtca tgaatagctt gtgcagcttt atctttataa accgcttgct tcaatttact 3064921 tgcatctgat gcattagtga taaaggcagt ttcaactaaa acactcggca ttttagaata 3064981 tttaataaca tagaaagcag ctgtttttac tccccggtct ctcgttccaa gattagccgc 3065041 taactttggt tgaatttgtt cagccagtct cttgctattt gcagcttgat atgttgtatc 3065101 gtagtacgtc tcacttccat ttggtgatga gctatcatta gcatttgcat gtatactgag 3065161 aaataaatct gcttgtgcag aagctgcttt atttactctc tcctgtaaag aataaaaagt 3065221 atcattagat cttgacagta ctggaagagc acctgaagca tttagctttg tattgactct 3065281 tttcgctata tcaaggttga cttctttctc aaggagtcca ttgccgattg ctcctgaatc 3065341 ttgatcaccg tgacccggat caataaagat tgtttcacct acaactggat tctttagctg 3065401 attagcaacc tttgtgctta cggcaggagt gtttccgata atcataaagt ttgacatgtt 3065461 tttacttcca ataattttac gggctcctgt agataaattt tcaccatttg taagaataag 3065521 agattgcttc ttcttagctg ccagtgtagc tcctgcaata gagtcagggt agctgaatcc 3065581 attgcttaca tatacggtgc ttgttgataa attaagtttt tgtacgatat ttgcagcaag 3065641 ctcatatctg tttgaaccgc taattcttgt aggagaaggt aacttgttgt ataccgtatt 3065701 gctgatactt ccagtgcctc ctacaacaac ggtactcgaa attcccttat cttttatcac 3065761 agacgtagtc gcactattta tagatgtttt atttgtaaaa agaattggat acccgttttt 3065821 cgctgcataa gggatgacgg ccggagcgtc tgcatataag aagccgttca aaataacagc 3065881 ttttgaagtc gcacccatcg cttttgccac ccgtgcagcc gtatcataac ggttgcttcc 3065941 tgcaattcgt ttaatactta tccccaagct tttaatctgg ttagcagtgt tagaagaaac 3066001 agcaggtgtt ccgcctacaa taattacatt tttagtctgc atctctttca atcttgtttt 3066061 cgtttcatat gaaagcttat cagaattagt gtaaagcaat ggcgcattct tctggtaagc 3066121 aagaggtgct gctgaaatag catctgcata ggaactccca ccaacaatta cagctgtact 3066181 tgctgttgaa tacatttgct ttgatatttg tacagcagtg ccgtatctat tgcttccccc 3066241 aactcttttc actgagttat cggccaaagc tgttggcaca aaaagtatga gccccagaaa 3066301 acacattgtt aggactttta tataagaacg caattgattt cctccttaaa tggcgttata 3066361 tcctaaaata atcaataact tgtcagagtt gtacctggat agtaaaattt caaaattgaa 3066421 ctatatgaat ctccagcttc tgctcttgct tttgctccat attgactcat tccgatcccg 3066481 tgaccatatc ctttaccgct gattgtgtac tttgaagtat ctttttttac agtcacataa 3066541 gtacttttaa atacagtcgc tccaatcatt gttcttaact cacttgttgg tacactaatg 3066601 gttgtaattt tgctcaagtt ataggagcca gtactgcttt taacaaaata cttcactttc 3066661 atcgatgctg tttttgcacg ctgcccttgt gtcgttccac taaagcttaa atcgtcaata 3066721 cttgcaattt tgacagaatc agcgcttgtt tctttatttt tcaagatcca gttcttaact 3066781 ccggaaagtc ttgcagaatc agtttcagtc gctgaagacc accaagaaga aggcttcgtt 3066841 aagtccaaag atttcgtatc tagctgttgt tttgacaaag taagcgtcca gcctatttga 3066901 ggatcctttg tatctttttt tgcaatcaag taaggtacac ttgacgacca cacttcatta 3066961 ctagcttctg tgtaaccacc attactggaa gaataagctg cagttataag agatccatta 3067021 tatttcagaa ctttcccctt cgtttgctct accgctttat tggtattcga attccaactg 3067081 tagccaccat aaacttgaaa agcggttgta tcaggtacag tagttcctgt ttttgttatt 3067141 gagtaggttc ttgcagcgac agtctgtgct ttaagagcct caagtgacca gctagcaggc 3067201 atttcattcg gaattactcc ttttaagtaa tcctcaaatg gaatattctc atttaccggt 3067261 cggatatatt tagtagactc aatagagaaa ttaaccgtgc caagatactg ctttccatca 3067321 agactaattc tgtttgaagt agaatagttt tctggtttaa ttcttaggga gtttccgtaa 3067381 gttttgatgt tttcaaggtt taattttccg ctgttgattt ttagattata ggtgccaccg 3067441 tcagctaaat aaaattcatc agcaagtgaa ttctcaactt cagcagaaat tgaactggta 3067501 cttccaataa agtcgtatgc atatgtggct ttatctttcg ttatactttt agccgcagcc 3067561 ggaacgctat cttgtttaac aaataaaatt tggctgtttt tcttcgaggc aagcgaagcg 3067621 cctatcaata cgtctgcata ttttgtcccg ttcgtcatta cgactttatc agccttcaac 3067681 tttagttgct taattatatt tgccgtaagt tcatatctgg ttgatccagg aatcctttgc 3067741 acagttgaag tttttttaat ttggttttct acactatcac tgacgctaaa tgaactgcct 3067801 ataatgatga cttgttttgg caaatcataa tccggaagct tgtctttctc tgtaagcaaa 3067861 atagggtatc cgtgtgctgc tgcatatgga gcaatggcta aagcgtcttg aaatactctt 3067921 ccggttacaa cgatcgcttt atcatagctg cccatttgct ttgcaatatt ttctgataag 3067981 acatatctat tttttccgct tatccttttc acagcgccat atgatttcag cttgttttct 3068041 acgtcttttg aaatgcttcg cgctccccca atgattaaaa tattatcagg gttaaactta 3068101 gcaatttgtc tttcagtagt ttttgttaac gtgtcaggct gagtaaataa aactggtgcg 3068161 ttcagttttt tcgccaatgg aataacaggc aatgcatcaa taaaaatatc tcggttcacc 3068221 aatatcactg tattaggatt tttccactgg ctgttggatg caagagtcgc agtttcgtat 3068281 cgtgaagcgc ctgcaaaacg atccgtaaca gcaacattat ctccagttac tttataaaat 3068341 cctgttggcg atagactgat gctagattta tttccaatat aatttaacaa tttaactgag 3068401 atgtttgagt ctgctgcaaa agaaactgat ggaatcaata ataagattgc agcaagtgaa 3068461 cacactatca attgtttgca agatttcaaa atttcaggtt cctccctata tcttagttgg 3068521 cacgttcaat atcttttaac agaagctgac cctcatcatt tttttcatat gtaatcgtga 3068581 ccttatctcc actgttaaac ttatcaagat cacttgtcga ttcttcagtg atatcaagac 3068641 taaccggctc attatctact gttacttcta ttgtatgagt atcagctaac cctacataag 3068701 taccttcttt tgtttcaatg ttactgtctg gcgatacatc ttcaccttga ctcttttgac 3068761 tattaacccc gcaacccgaa agaagcaata taaagaacag taaagcaata aattttttca 3068821 tttttttcac ctcattatat tttatcgtca acctatttta tattttaaag aaaaattaag 3068881 aaacaatgaa actttttttt ataaaaaacg actattttag gatttcattc ttgtattaaa 3068941 tagagttgta tttattggaa atttaactca taatgaaagt aatttaacag acgaggtgca 3069001 aaggatgaga aacgaacgca gaaaaaagaa aaaaacttta ttactgacaa ttttaacgat 3069061 aatcggactt cttgtactcg gaactggcgg ctatgcatac tacttatggc ataaagcagc 3069121 ttcaaccgtg gcaagtattc atgaaagcat tgataaatct aaaaagaggg ataaagaggt 3069181 cagtatcaat aaaaaagatc ctttttccgt cttaatcatg ggtgtggatg aacgcgacgg 3069241 cgataagggc cgtgccgata cgctcattta tatgaccgtt aacccaaaaa cgaatacaac 3069301 cgacatggtc agcattccgc gtgacacgta tacaaaaatt atcggaaaag gcacaatgga 3069361 taaaatcaac cattcatacg ctttcggcgg cacacagatg acggtagaca ctgttgagaa 3069421 cttcctcgat gttccggttg attattttgt gaaagtgaac atggaaagct ttagagacgt 3069481 tgttgataca cttggcggca ttacagttaa cagcacattc gcgttcagtt atgacggtta 3069541 ttcgttcggc aaaggagaaa tcacgctgaa cggaaaagaa gcgctcgctt atacccggat 3069601 gagaaaagaa gatccgagag gcgacttcgg acgccaggac cgccagcgcc aagtcatcca 3069661 aggtattatt aataaaggcg ctaatatttc ttccatcacg aaattcggag atatgtttaa 3069721 agttgttgaa aataatgtga aaacgaactt gaccttcgat aacatgtggg atatccagtc 3069781 cgattacaaa ggtgcgcgga aacatattaa acagcacgaa ctaaaaggta caggcacgaa 3069841 aatcaatgga atttactact accaagctga tgaaagcgcc ctttccgata ttacaaaaga 3069901 gctgaaggaa agcctcgaaa agtaaaacaa aaagaagctt cgcacaatgt gcaaagcttc 3069961 ttttttattt gcctgtaaat gaatccggtt gttcttttcg atacccgtaa tgaaacagca 3070021 attcttccac aatccggcgg gaagcctctc catctccata cggattagaa gcctgggaca 3070081 ttttcttgta ctcatcagga tcagttaaca gctgttttgc aagctgataa atgttttcct 3070141 catccgtacc tgcaagtttc agcgttcccg cttccactcc ttcaggccgt tccgtcgtat 3070201 cacgcagaac aagaaccggt ttcccgagag atggggcttc ctcctgcacg ccgcccgaat 3070261 cggtcaatat aaaatgcgat ttcgctgcaa agttatggaa atcgatcacc tctaaaggtt 3070321 caatcagatg cactctgtca gaatcaccaa aatgcttatg agccgcttcc cggacaacag 3070381 gattcaggtg cacagggtaa acgacttgta catcttcaaa ttcccctaca attctgcgga 3070441 tggccttaaa catgttttcc attggctcac ccaaattttc ccggcggtga gcggtcaaga 3070501 gaatcatttt atcctcaccc acctgatcga gaacaggatg tgagtaacca tccctaaccg 3070561 ttgtgttgag tgcgtcaatc gctgtattgc ccgttacaaa aatagagtcg gcctttttgt 3070621 tttcttttaa taaattgtct ttcgcctggc ctgtcggagc aaaatgcaaa tcagcaatcg 3070681 cccctgtcat ctgtcgattg agctcttccg gaaacgggga atacttattc cctgtacgga 3070741 gccccgcctc cacatgaccg acagcaattt gatggtaaaa agcggctagg cttccggcaa 3070801 acgtcgtcgt cgtatcacca tggacaagca caatatcggg tttgatatct ttaaacaact 3070861 catccaatct tacaagtgcg ttagacgtaa tctctgccag tgtctgccgc tccttcataa 3070921 tgttcaaatc gaagtcaggc ttgatgtgaa acgcatctaa cacctgatcg agcatctgtc 3070981 tgtgctgtgc agttaccgtt acataggaat ctatttcagg atattttttc aattcaagca 3071041 caagcggtgc catcttgatc gcttcaggcc tggtcccgaa aacggtcatc acttttagtt 3071101 ttttcatatt tgtcacctgg ttttctgcta tagtaaataa attcatacta catattctac 3071161 atgaaaatgc atcattttaa atcatttcat tcttgattca aataaaatga tataagtttt 3071221 aatattaagg ataaagcttg tttaaaaatg gtttatccga tatcataaaa atgtgtaaaa 3071281 acatattgaa aagggtaaat agagaatagt ttaaccataa attttttcga tcataaggaa 3071341 ggtgcctttt aaatgaaaaa agtacgtaaa gccataattc cagcagcagg cttaggaaca 3071401 cgttttcttc cggctacgaa agcaatgccg aaagaaatgc ttcctatcgt tgataaacct 3071461 accattcaat acataattga agaagctgtt gaagccggta ttgaagatat tattatcgta 3071521 acaggaaaaa gcaagcgtgc gattgaggat cattttgatt actctcctga gcttgaaaga 3071581 aacctagaag aaaaaggaaa aactgagctg cttgaaaaag tgaaaaaggc ttctaacctg 3071641 gctgacattc actatatccg ccaaaaagaa cctaaaggtc tcggacatgc tgtctggtgc 3071701 gcacgcaact ttatcggcga tgagccgttt gcggtactgc ttggtgacga tattgttcag 3071761 gctgaaactc cagggttgcg ccaattaatg gatgaatatg aaaaaacact ttcttctatt 3071821 atcggtgttc agcaggtgcc cgaagaagaa acacaccgct acggcattat tgacccgctg 3071881 acaagtgaag gccgccgtta tcaggtgaaa aacttcgttg aaaaaccgcc taaaggcaca 3071941 gcaccttcta atcttgccat cttaggccgt tacgtattca cgcctgagat cttcatgtat 3072001 ttagaagagc agcaggttgg cgccggcgga gaaattcagc tcacagacgc cattcaaaag 3072061 ctgaatgaaa ttcaaagagt gtttgcttac gattttgaag gcaagcgtta tgatgttggt 3072121 gaaaagctcg gctttatcac aacaactctt gaatttgcga tgcaggataa agagcttcgc 3072181 gatcagctcg ttccatttat ggaaggttta ctaaacaaag aagaaatcta aacaaaaagg 3072241 ctattggaca ttcatccaat agcctttttt tatttcaaca tcaaagtcaa tgtatgctct 3072301 tcattatcaa ctgcgaagac ctgatcaacg gcctgccgca aaaattaata atcccagaca 3072361 aacacactga ttgtagagtt aaacaaacta aatgaaaaca taaatacaaa catgcagatt 3072421 aaatagtaaa tatcttgtat tcaatgcaag ctaagtaaac accacttgct aaaagaacaa 3072481 tgactaaaca accagcatta caaaataatt aaataaattt gaagcaatta caacagaagg 3072541 cagtgaactg tcggaaagtt cattttggct accatattaa tccctttaac tacgctgttg 3072601 gatttatcaa gaattgtcgg gctaatagaa aaccacggaa tcaaaccagc cagcattcaa 3072661 acgataaaag gcacttctcc gatacctgtt atgaccagct tactgttgcg catcccaaat 3072721 acaaaccagt acgccatcat tagaataagg ggatttaaaa cctgccataa tacaccaaaa 3072781 taattgattt tttggatctt tcggttaaag aaatttaaaa gtaccagtga atattgtaac 3072841 aaatgttgag tttttttcac ttttaaaaag taaagagaag tctcgcagaa cttctcccaa 3072901 catttgaagt gtcaatataa aacaaaccaa cctcatttag caactttatt attatctaat 3072961 tccaaaatag cattataaat acgattccta ttatttttat cagtatatgc aaaaaagtta 3073021 tctactcttt ttctatactt atcttccata cgactattgt ttttcatata atagataact 3073081 ttatccacta agctattatg attttctaat acatcaccaa accccatttt tttataatca 3073141 taataatcaa gtttaaaatg gtatgacttt tcgtattgat aataaataac aggttttttc 3073201 tcatatgcaa aatcaaacgc aacagatgaa aaatcagtaa tcattatatt agaagaatta 3073261 aatagcattt gatagctgct gttatagtcg gcaaactcca cataatcatg cttttcaaag 3073321 tctacaatct gttgctgaat atctgggtga ggaaaaaaag ttattttata attatttttc 3073381 ttagcaaatt cgattagccg ttcatcatta atcaaagcat tatacctaga aaaatattca 3073441 ctatctttaa atttcgggtt gtacggtctt actccttttg cctgatcttt cggtaataca 3073501 atatcttttc tccaagtcgg cattattaga agttgctttt ctccctcact cttcttaaga 3073561 ttatcgtatc tcggaaatcc acccaacaaa atattctctt ttttatagtt gtaattccct 3073621 ttcacaatag accgatattc aggtttggca gaagtgacta ataatttgat attcttgttg 3073681 tatttgttta accattcaga atgatctgcc attgttattc cgtgctgtaa aaagataaac 3073741 tcaaagttaa ataaatctct aaaataaatc tccatattaa aaaatggatt tacaacccat 3073801 atatctgcat gtgtcgatat tactttggaa gaggataagg ttaaaatttt atgtctaaaa 3073861 gatctgtatg gtatgacctt tccatatttt ttgattctgt cgtaatcctt gctatctttt 3073921 tttattataa agtatttttt taccccatca ttcttgttga ttgcatattt aaagaggtgc 3073981 tcggcattat catcagcttt gtcttgtctg tctatgaata accatactgg ttttctatta 3074041 aaaatagtga aaacatggtg taccattctt gccatcagtg ccttcttaat cgctgatttt 3074101 cgtttttttg atttttcccc tgatttatgt agggatttta agaaacgaaa ctcttttata 3074161 aatctatttt taaaattgtt ttttttgaac attaattttt tataattata ataaaaaata 3074221 taatcttttt tagccacata agtattatat aaatcgtttg acaaacctga atacttgaaa 3074281 aaacgaagtt ttgtcaactt ccttttttta cccttagtta taaaaaactc aatatgatga 3074341 ttatctgcta gatgaccttt gggaatatct attgaaaaac cgggatattt ttttattact 3074401 tctcctaaac ttatataatc attatgctgt ctttttatat tctttgcttt tatttttgtt 3074461 tcgccaattt tagcataaaa cttaaaacct ttagaattaa acagcgagct ccaaaagcct 3074521 tctatgtgaa tggaatcctc attttcttct aaaatttcaa tagttaaagt ttgatccgat 3074581 aatttcgaaa caattttacc ttctctgtat aaataataat cctgttcagt ttctctttca 3074641 tatacatacc tactataatt ttcaccgtgc tttattttta aagcatgata taaatagaaa 3074701 tggctgacac tttttgtttc aatgatgaca tcgtcgtcaa tatacgacaa tacttctcga 3074761 atcaatgtta aaaattcact gtattcattt tcgtctaaag gtgtttcact gatatcctta 3074821 atcaataatt tccacttcaa atcatgcata accatatatt gaagaaataa aggtattttc 3074881 tgttcatgat tttttataat atcgattaaa ttctttgaga aagtgataag tgaatggtta 3074941 aaccaattct tatttgcttt agcagtctgc atggcagatg atccatcttc tctaactcta 3075001 taatggtatt ttgcctcttt aaccagacca tactttttct tttgcgatat gattaaatta 3075061 actagtttgg catcttcacc tattttacaa ttttcatcaa acctgatatt tttcaaggca 3075121 tcttttttta taaatgtaga acaacaatga gttaatatat gatgcggttc tttttctaca 3075181 tccaaaattc ttgtagaaga aaacttatta tttagattat gttctccagt tcttccttct 3075241 gcaaaaaaaa tagggattgc tacaatatca atttcattct tatgttcgtc aaagaagttt 3075301 aaaacatttt cgaatgttcc ttctgaaact aaatcatccg gatccaaaaa ttgaatatat 3075361 ctaccttcag catactttaa accataattt cgagcactgc tcactccgcc attctgtttc 3075421 tttgcataga caatgttatt gggatatttc tgagcatatt ctttacaaat gatttcactt 3075481 ttatcggggc tatcatcatt caccagtatt aactgaatat tctcaaaacc aatagtttgg 3075541 ttaatgatac tttctatagc ttcagtgaga tacaactcaa cattataaat cggcattata 3075601 acactgaaat catagttaaa acttttttcg ttcataaaag attactccta acataatgtt 3075661 tatatgaata agaattcggg taaataaaat taagaaacaa gagagtacta atttttgcaa 3075721 aacaatttta atttagtaaa atgtatgaaa agcattcctt accttttttt aaaaaccctt 3075781 gtaagcaaac ttttaaaaat gttcacatgg ttaagttcta aagaatcatt tggtgttttt 3075841 agtacaaagt caaatgcaaa ggcccaaatc ggtatttcga caacaaaacc agcatatcta 3075901 aaatctctta atttatatcc ccatacttca attgtttttt tcagttcttt tcgtttgcat 3075961 ttttttaatc ttttaaaata ttttatatat attctgtcat tttctttcat ctcataatac 3076021 tggttaataa agtgccctgt taattcaagt ctaagccctt ttatttttgc cgaagtaaca 3076081 gtacatgaac tatgcagtac tctttctttt tttatatttt caagagcttc tgtattttct 3076141 tttaataagt gaaacataaa ttctttatag tacatcggca tatcttgttc ttttataaat 3076201 tgcgggtcaa taaattttaa aactttaata aaatcatcaa caaaaactct ttgttcttgt 3076261 tgatctaaaa cagacttata aacatctcta tagttcggat ataaaaacag ttttatatga 3076321 tatacaatta aaaattgcaa ataaggcaaa actatatcat atttgttgaa tgaatccatc 3076381 aacaaagtca tgtaacattc attcaacaaa tatgtgtacc tttttttgtt aaaccatgaa 3076441 cgatcaacta aagaatcctg ttctttccgt tttctataaa aatactttcc ttctgcaact 3076501 gctccgtatc ttttttcttt cagtaataac tggttaaaaa agatagcgtc ttcccaaaac 3076561 tttatagatt catcaaaaag gacggtacta gttagtgtat gtcttctgta aaaagtgccg 3076621 ccaatataaa aatgaatagc tttataatcg ttgagaatat ttataactct tgttcctttt 3076681 tcaaatctat tatttaattt atgtccccct tctttttcac ctgtgtaata aacaggtaat 3076741 accgcaatat ttacatgttc ggaatcacaa aaaaaatcat aaacactttg cagcgcattt 3076801 tgagagaatg catcgtcaga atcaagaaaa ccaataaatt tagatctttc gcttacattt 3076861 gataatccac aatttcttgc agcagaaggt ccagagtttt caattttcat gattttaata 3076921 ttattaggat atagattttt aaaggattca caaatttgag gactgctgtc aacactacca 3076981 tcatctatta atatcagttc tatattttcc ttaaatccaa ttgactggtt aaggacactc 3077041 tctattgaat atcttaaata attttcagaa ttatatattg gtataattat agaaaacatg 3077101 tttgtacctc tttatttaga agttaaagga tcgtttcaat tactctttta gaagccttgc 3077161 ctcttctaaa ttacaaaatt tattataaaa atcctcatag ttatgatcta tataaggatt 3077221 atgtaacaac tcttttaccg tatctataag ttcttcactt gtttgaagca agtttcctgg 3077281 cgttttttgc tgaaaattaa agtaaaaacc tctgatacag tctctataag ccgggagatc 3077341 atacacaaaa aatacaaggt ttttttaaaa attcatatta tcaaaaaaga cagaagaata 3077401 atccataatc aataaatcac taattaaata taaatctcga atatctttat ttaaagaaac 3077461 atcgttcaca aaatatttat atttccctaa ttaaattgtt ctgaaactgg ataataccat 3077521 tcttacaaga ataaccatag agtctccaag gttccctctt catttcctct aatcaaatta 3077581 aagttaaatt tatactggcc agctttctta aaattcatta tcccgcaaag ttggtgcata 3077641 taaaattatt tttctttaat tccttatttg ataatgtaga attggtaggg gattgtagct 3077701 aaactgtttc cagaatagct ttcaaataaa attaatttat tgtttcttgg cagaaggaca 3077761 aaaattttaa acaaaactga ataaactcta actagtaaac ttctgcaatt ggttataata 3077821 aaaatttcat cagtgaactc cttaaagagt gaagattaat atttacgcaa acaagaaaaa 3077881 aagaagcaac tgaatttact tcaagcctct tttagttagt gcttctataa actagccata 3077941 tcttttctga tttgggtagt tgaaatgcct gctattcttg taaggtaaat ggcctcatag 3078001 tattcctttg tagacaatcg tacgattaag taatcccagg ttcttttgct ctttccagta 3078061 gcttcatatg tccatagtga aataaatcaa acattccgta cgtatcactt tcttcattag 3078121 ataacatcac cttccaacct tttccaactt agaaaaaaca aaaatcctta actgattgtt 3078181 tatcatttcg acatattttt tacgttccat taataataaa caataatagc atatgttcct 3078241 ataaaagtta aggctcttta aaaatgtaaa tcatcagcac tttttgacaa tatcgttgca 3078301 ttgatgtgta ttttttacag atctgatatc ttatctatac tcattacaac aagttttcta 3078361 ttccggaaga gtcaattctt tttgtcgcgt tttcaagtgt aatgattttc tttctgctgc 3078421 gtcatttatt ttgtacgccc tcctcatatt acttcatcgt caaaacgtga aggaattgta 3078481 atacgtagtt cctaaaaatt ttcgtggtaa aatttagtga agtctttatc aggctaaggg 3078541 actttatcta aactacgaat tacatatgga gatatataga tgaaaaggag ggttgatatg 3078601 atataaacga aaatcaatta gataaaggaa aaactgaaca cttctgaaaa aagtgataag 3078661 tttctttcac tatatcctcc aaaaagaacc taaaggtctt ggacatgctg tctggttcgc 3078721 gcctaacttt atcggcgatg agccgtttgc gtttctgctt ggagacgata ttgttcaggc 3078781 tgacacacca gggttgcgcc aattaacgga tgaatatgaa agaacacttt cttctattat 3078841 cggtgttcag caagtgcctg aagatgaaac acactgttat ggcatcatcg ccccgctgac 3078901 aagtgaaggc cgccgttatc aggtgaaaaa cttcattgaa aaaccgccta aagacacagc 3078961 accttctaat cttgccatct taggccgtta cgtattcacg cctgagattt tcatgtattt 3079021 agaggagcag caggttggcg ccggcggaga aattcagctt acagacgcca ttcaaaaact 3079081 gaatgaaatt caaagagtgt ttgcttacga ttttgaaggc aagcgttatg atgttggtga 3079141 aaagctcggc ttcatcacaa caactcttga atttgcgatg caggataaag agcttcgcga 3079201 tcagctcgtt ccatttatgg aaggtttact aaacaaagaa gaaatctaaa caaaaaggct 3079261 attggacatt catccaatag ccttttttta tttcaacatc aaagtcagtg tatgctcttc 3079321 attatcaact gcaaaaacct gatcatctgt attcacaaga aaacgcttct tgctgctgtc 3079381 atacaataca tcgctatcac ttaaggatag tgacgccggg ttgataggag aaatgttatg 3079441 aaaaataagc tctgttgctt tatcattctc cagtacataa ctgatttttt cataatcaaa 3079501 attcagcgtt tttctgccgt cagccttatt tccttcagta taaccattca atttcgattg 3079561 aatgctggtg ctgctgtctc ctaggaattt cagaaagtat tcataggaag atgctgcgtt 3079621 ttgcgagaca taagacgtaa atgcagtggc atgcaattca gcgtgtttca tgttagttgc 3079681 aacagcgctc tgtttcacat aataagagtg cccgtcaaac tttattttcg ctgcttgttt 3079741 gccttttgca gctaccgtta cttttgtacc gaatggcagt gtaacgtcag ccttctgttt 3079801 caaaccctga tccttataag cagccgcttt ttcatttgct ataaaccctt gcttattgat 3079861 tgcagttaag cgttcctctg acttgccctt tgcatcgcca tgatggttct tcacttcatt 3079921 ttgcggaata gcgccaaacg aagcaattgt acgaagcggg gcattaaaga acatcgttcc 3079981 cgccatgaag acagtcagaa tagacaaaat agcaatttga atggcattgg ccagtgattt 3080041 cggctttttc ttctttttgc ggaaacgggc aaacgcttca ggatcttctt tcttcctctc 3080101 ttctgtctgc tcttttttat atgtctcttt ttcttttttc gatagcttat taaaccagtc 3080161 aataaacgct ttgtactctt tcacaaccgt ttttgtttca tcaaacatac gaagctcgcc 3080221 atagtgcatc caagcaacac ggtcacacat cttttcaatc tgaccgattg agtggctgac 3080281 aaagaaaatc gtttttcctt gctttttaaa ctcatttatt ctgtctacac acttctgata 3080341 aaacgtttgg tcccccacag aaagagcttc gtcaataatt aaaatgtcag gatcaatatg 3080401 cacggagatc gcgaaaccga gacgcgactt catcccgctg gaatagtttt taaccggctg 3080461 attaataaaa tcgccaatct cggcaaattc aacgatgctg tcatacatat catcaatttc 3080521 tttattggtt aaccccatca tcaaacactt gagccggaca ttgtcccggc ccgttaattg 3080581 gttattcaaa ccggcagcaa tcgcaatcag cgacggctgg ccgttcattt caatttcacc 3080641 gctggtcggc ggaataattt tagccagcag gttagacatg gtcgattttc ctgacccgtt 3080701 tattcctaca aagccgattg tctccccttc atacacgtca aaggagacat tccgcacagc 3080761 aaaaaaacca ttatccttag ccggaaaaaa caatccttta atcttgtccg attgtttttt 3080821 atacaaatga tactgctttg aaacatttcg aaacgaaact tttagtttca tcgtaaaatc 3080881 tccttacgta ttaaagaaag tcaacaaact tgtctctgaa tttcatatgc aggatagaac 3080941 ctactaacaa taaaaggaat gtgaacaacc aaaagtacag cgtgtacttc atgtcatgga 3081001 aaaaccatgc tccatctaag aagctgttcc ggaatccttc aataatatag aatagtggat 3081061 tcaacttcag aacaggcact aattcggggt ggctttgacc gagtttcgca ttaacatccc 3081121 aaaaaattgg caacaagaaa aacaaaagtc ttgttacggc ctgcagcaaa aattgataat 3081181 ctctaatcag cacactgatc gttgagttaa acaaactaaa cgaaaacata aaagcaatca 3081241 tacagatgaa gtaataaata tattgtaacc aatgcacact cgggaacaca ccattaacta 3081301 ggagtacaat gatataaatc accatcatga tcatataact aaataagtta gatgcaattg 3081361 ccacggacgg tagagaacta atcgggaagt tcattttagc caccatatta atgcgcttaa 3081421 atacactatt tgatccatca agtatagttg gactgatgaa aaaccatggg attaatcctg 3081481 ccagcatcca aataataaaa ggcacttcgc ccgctccggt tgtcacagga ccgccctttc 3081541 taatccccat accaaatacg aaccagtagg ccagcatttg gataagcgga tttaagaact 3081601 gccataagac acctaaataa ttcatttgat atttagactt ggtttcataa gccgccaatc 3081661 ttaaaattaa aggaaatgac gttatttgct ctctgagtat acgcaacaaa tcattcattt 3081721 tttatcttcc ttagacttaa ttgtttttgg gaatctttct gtttaaaatt tgaaagcacc 3081781 gctgattatt gtaacagatc ctgcattttt tttcacttct caacaagtat ctaaaaagct 3081841 gccgaaaaat cgacagctat acattttata aaataaccta aattattcag ctttaaatac 3081901 agtattaaca accttttcag atgaacgtcc tgactctaaa tagcaaaact tatcatagaa 3081961 aggaccaaaa gaaaccggaa gcttataatc aggcgatgag atctgcttga tagcctcaat 3082021 cgtttcttca gtagttttta ccaaaggacc aggagcttct ttttcaaaat caaagtagaa 3082081 accacgcaac ttgtcccggt aggtttcgat gtcagggaca aagaatagca ttggccgttt 3082141 taaatttgca aaatcaaaga atactgaaga ataatcagta atcagcaaat cagaaaccat 3082201 atacaattct cgaatatcct cataagcaga aaaatcatat gcaaatcctt caaaaggacc 3082261 taaatcaaaa ttctcagcta ccagataatg cattcttaag attacaatat attcatttcc 3082321 aagttcttgt ctaagttgat gcaaatctaa atcgagatcg aacttataac gcccttttgc 3082381 atagaactga tcatctctcc atgtaggggc atataaaata acctttttat cacgaggaat 3082441 atttaaccta ctctttatca atgatattgt ttcctcatta ttatcattat gaagaaaatc 3082501 atttctagga tatccagatt caatcattgt cttgttaaac tgaaacgccc gtgtaaagat 3082561 ctcagttgaa taaccatttg gggaaatcaa gtaatcccaa ttagaagctt ccttgataaa 3082621 attcctttta tattttttgg tgtttgtacc aggcatatgg acttcttcca tatccattgc 3082681 aagtcttttt aaaggtgtgc catgccatgt ttgtaaatat gttgtatgac taggtttcgg 3082741 aatccataat ggaagccggc tgttaacaac ccaatactca gctcttgcca tagcgaagag 3082801 ccattttaat gagaggcgat taatgtaagg aattcccttt tcatcaaaag gcgctgaata 3082861 ttgtttattt acactccaat acattttata ctcagggtgg ttttcccgca tatattcgta 3082921 aatcgctctc ggattacaac tgtattgttt cccattaaaa ctttcaaaaa tgactgtttt 3082981 ccttttaact ggcattctgc tagccatcat gaatagagat ttgtatgttt tagtgattaa 3083041 cttgtttctc atttttgtga tcttttttat ttttgatact aatctcttct tctttccttt 3083101 aataaagtat ttcatccttg ttttcaggct atagtcgttt actctgatac ctagagtctg 3083161 ctttttcttt ttcttaaaga cttcataacg aactggtgcg ttgtttgttt taataatact 3083221 tactaatcct tttaatttgt tttttcgatc tcctaaaaca agagcagtgc tgttgaactg 3083281 aatatccgtt ccttcatcgt cattgcatat atactccata aaaagacgat aaacataacg 3083341 tttttcattt gagaaaggaa tttctttcaa aggcactttc acttcaaaat catacagttc 3083401 cggaacaaaa ccatctgctc tcatgttttc caggccatgt gtttttcttt ctagcttgat 3083461 tggaaatttt tcctcaatag gtgtttctcc accctttttt aaaataaggt tcaagttttt 3083521 tatccgatat tgattttcgg aactcaggta ccccgcataa cctgttatgc ttatttcttc 3083581 agagctaatc tcgatttgat caaatctgat gattttggcc tctcttttca ccttaataga 3083641 aaagttgcct ttatcagttg tataaggtaa aatcaaaagt tctgtggttt gatcgacatg 3083701 aaaggcgcgc tcaattgaat ttacttcagc agaaagacgc ttcaagagtg gttcctgctc 3083761 cgcatcttca tatttttttc gaaattcgac ataaaaatca tatgtttgtc ccatttcaac 3083821 aggcataggc aaaacatgag catttatctc agttttatac tctaatgagc cagtgttttg 3083881 aagcggaaat tcagattccg ttcctgaacg tctctctttc agctttaaaa ataactggta 3083941 atcctctaaa aattggtgtt ctgaatcaat tgagattaac aattcaagac ttcctaaatt 3084001 gtttttcaag cttttcaaaa tacatttaat cacagtgttt tcaatcatta cttttttctg 3084061 ctcctctgta taaaagctct ttcctttttg cttcctttta ttagtgtcaa ctactaagga 3084121 cattaactct cttttatttc cgtgaccctc caagagaaat tgcctttaac tgttgtatag 3084181 ggctctactc tatagccatt attagtatct atactgtttc ctgacaattt tgtttcttca 3084241 ctcgaaagtc ttcgcattgt tttaatatgg ccatttgcat tgaaaacaat ataaaaatca 3084301 ataacttggg ttttattagc agctatcttt tcaatattta catctttttc gagatcaatt 3084361 acaaacagtt gatcattttg taagtttgtt gaaataattt cagccttatt ctttctgtcc 3084421 aagcccacta aacgtatttt tttaatatca ttatgatcaa aattctcaat gtcaatttct 3084481 attttagttt tatcaaaatc ctcagtatag gaactaatag aaggatcttt ttttccaacc 3084541 tttttagaga acttctctct ttctattcgc acctcaatca tctgattaag agcaaaagcc 3084601 caattttcaa tatagttggg tcttgaatat ttttcagcca ttttaaaagc ttgttctgaa 3084661 aatttttgat gagtactttc atctttcatc aaagagataa tagcttgacc caatttctct 3084721 atattatact gttcaatgac atatccattt gctccgtcag taactaagct ccttgctccg 3084781 taatcataat cgtatgttac aactggacat ccattgctca gtgcctccat atttgataga 3084841 ccgaaccctt caaaatgaga ggttgaaatg gttagccaag ctttttgaaa ctctgagtca 3084901 gggttatccg tatagccttt caaaaagaca ttgttctgca gtttggtatc ttcaatttct 3084961 ttttttattt tttcgaaatc ttcacccgat ccgaatatat caagttttgc ttcaggaatt 3085021 tctttcacga ctaaactaaa tgcttttact gcatgtatca gatttttcat agatgcaagt 3085081 cttgaaataa tgacagcttt gtatttttca ctcggcacat tcaatacagc gggatcaaga 3085141 ggcttatcaa ttgtatgcgg agtaaagaaa aacgtctctt gttcccctga aatcaattta 3085201 aaatcttcta gctgctcctc agttataaaa aagacagcat ccaaattata catctgacta 3085261 aatacttctt tatagcgacc cttaatttga tatttattgc tgccgtaatg cttgttatga 3085321 ataattgctc cataatagga agaaggtgat tttttcactt taaagacatg tttgtcttgc 3085381 ggtctgctgt ccactaaaaa caacttaggt ttatcatttt gtttttgcag atattctatc 3085441 caatattgac gcagttccga ttcatctttt acttttatct caccctcaag ggagtaccaa 3085501 ataatatgag ataattgaac atctttttct tcattgttcc atacatagag tttgtctaaa 3085561 tatacttgat tttggtcatt aatatattcc tgcagataca tcttgtttag ctgcacatca 3085621 taatgagtaa cgagaactaa gtttccgttc ttcgtatatt cctctctctt tatgagctgg 3085681 tttttatcat tccaatagtc gacgtaccgg atagtttctc catctccgta gtaaactaca 3085741 gacatttcat tgttcttctt accaaacaat ctcaacagag tttttgcaaa tttccccatt 3085801 ccaacttgct tttttatctg gtcaaggcct atcctttctt cgtatgatct tttcccattt 3085861 gttctaacac ttaaaaaatc atcgaataga ttaataacac ttgtgaattt tttatcaatc 3085921 ttaccgttgc tgtacaattc atcaattttt gaagacaact ctaaatcaaa acgaaacgtt 3085981 aagaaaaagg tgttttggtt acactcttct ccaaataatt ttgaacgcaa taataatgat 3086041 ttcgtcagac cgccataatt acttggcagt ccaccagaga taaaataata atccatgtca 3086101 ggaatttgtt ttatattaga ttcactcacc gcatgtaaag acaatttttt actccctttc 3086161 ggcatctaga atatatgatc attgaaattt atatctaccc ggatacttta gtcacaaaaa 3086221 tcaatgtaag catcaaaaag tacttcttat ttcaataaga agtactttaa ttagatattg 3086281 aaccaatgat atcaggatcc taaattataa accagcaatt tcctctttga tctttgttgt 3086341 agagatgcct tctgttcttg ggaggtaaac aacctcacac tgatctttga gaaagtcaaa 3086401 tttaccttcc cagtcatccc ccataacaaa aacatcaata ttatgatcaa taatatcttg 3086461 ctttttttgc tcccaattct tttcaggaat tacttcgtcc acatatcgaa tggtttctaa 3086521 aattaattta cggtgctcat agctgtgata agcttttttt tgcttttgta aattgaattc 3086581 atccgttgaa atagcaacaa ctaaataatc accaagctgc tttgcacgct caagcaattt 3086641 aatgtgaccc caatgcagta aatcaaaagt tccatatgtg ataacttttt tcatttaaag 3086701 aaacgctcct tcctaatgtt aaacactatt aaaaacacta ctgacgttag cgattaaatt 3086761 ctaaaaacct gtttgtattc cttatatcga catatttctc gtatgtcttc actgatcatt 3086821 aattatagca taccgcctaa aaaaggttaa gtactcatga ggagaaaaac attccaaaat 3086881 atgtaattac actcagactc cattggcacc aaggtctgtt gttcattcgt tcattcaatt 3086941 gtaaaattgg aaacatattt aaatttaatg taaagataat gttaatcctt tgttgaagat 3087001 ttatgttaaa atataaggta gcttgatttt gcttttagaa actctcggtt tttaactata 3087061 taaatagaat cttaaaggaa ggaggagcca gacatgcaaa cagagactat tcacaatatt 3087121 ccttatgtta acagtaactt aacatcattt atcgattacc tagagaaaca ttatattgat 3087181 caaaagattg gtgctgtcat ttccacagtc aaccctgaaa ttgcatttgc agctattaaa 3087241 gatcgggact actttgatgt actatcttct tcaaacttca ttttgcctga tgggatcggt 3087301 gtagtcatga tgtcacgttt gactaacaac aggcttcagt cccgaatcgc aggttacgat 3087361 gtttttaaag aacttctggg cgttgctaac aaaaagaaaa aacgcatatt tctgtacggt 3087421 gcgaagaaag atgttataaa aggtgttgta tccaaaattt cttctgaata cccaaacatt 3087481 aaaatcgcag gttattcaga cggttatgtt caagatcgca ccctagtggc aaaacaaatt 3087541 gcaagagcaa atcctgacat ggtattcgta gctttagggt atcctcatca agagaaattc 3087601 attcataact acagacactt gttccctaaa gccgtatcta taggtctagg aggaagcttt 3087661 gatgtattta gcggtaatgt caaacgggcc ccttcctgga tgatacgttt aaatttagaa 3087721 tggttctacc ggttaatctt gaatccatgg cgatggaaaa gaatgcttag catcccaaaa 3087781 tatgctttaa cggttttaaa agaagaaaaa aacaaaaaaa ctttctatcc aaagcctgaa 3087841 aaagatcata caaaacagat ttaaaaacaa aactttcaaa taaatggatg ataaaaatga 3087901 aaataagatc actactggcg aattgctatt tgtatttttt atcagcaatc gccttttttc 3087961 tgcaatgggt gaaacctgaa agcaaagtga ccctcctgat ctcattcgaa gcaaacgcaa 3088021 aagcgattct tgaggaatat gaacaaggac aatactctta taaacttaac atcctgtata 3088081 cccagcaggc ctctgctatt gccgagagct tcccgaatgt agatgcatat ttattacaag 3088141 aaaaaaaccc tatccatctc attaaagctg tatacctaat gtttaacagt aaagtgatca 3088201 taacagataa ttactttcta ttaacaagtg tgttaaataa gcggaagcaa acgaaatgta 3088261 tccaagtatg gcacgcaaat ggctcactca aaaaatttgg tttggaagac attacaaaca 3088321 tgcaacggac gaaaactgat attaaaaggt tccaaaaagt atacagttcg tatgattatt 3088381 taactgttgg ctcagaagag atggcaaata tcttcaagaa atcatttgga ataaaggata 3088441 accaattatt aaaaataggt gtacctttaa cagaccctta ttaccgagaa aacaagaaaa 3088501 aaatttcaga tactctaaac atacaaagaa aaaaaataat cctctatgca ccgacgttta 3088561 gagattataa tatgcaatca attcaattgc cttttacaga agaacaatta attcatcagt 3088621 taaaagaaga atatgtttta tttgttaagc tgcatcccgc cattcagaac aatattgata 3088681 ttaaatattc cagtgattat attaaagatg tttctaacta tgccttgttt gatctactca 3088741 tggctgcaga catattaatc actgactatt cttctgttcc ctttgaattt tcgattttaa 3088801 ataaacccat tcttttttat acttacgatt taaaacttta tcaacagaag cggggattgg 3088861 ttgataatta tctttccata atacctggaa gagcctgcta tgacagtgaa tcattaataa 3088921 atgaaattca aaccccattt aattattcca aaataaaagt tttttccgat agatggaata 3088981 agtattctga tgggaattca agccaaaatt tattgaattt catcgaaaat ttaataagct 3089041 aaatgatgac acttgttcaa aacagaacaa gtgttctttt ttctattgaa taccgaacgt 3089101 atgtttgctt taatgtaatt agttgcttat ggcagcaaat aataatagag gtggtaaatt 3089161 tatgagaaaa aaagaactgt ttgatttcac caacatcacg ccaaaattat ttactgaact 3089221 acgtgtagca gacaaaaccg tacttcaatc attcaatttc gatgagaaaa accaccaaat 3089281 ttatacaacc caagtcgcaa gtggattagg aaaagacaac acccaaagct atcgcataac 3089341 tcgtctatct cttgaaggtt tacaattaga cagcatgctg ttgaaacatg gaggtcatgg 3089401 tacaaatatt ggaattgaaa accgtaatgg caccatttat atttggtctc tatacgataa 3089461 accaaacgaa acagataaaa gtgaattagt ttgtttccca tataaagcag gcgcgacttt 3089521 agatgaaaat tctaaagaac ttcagcgatt ctcgaatatg cctttcgatc atagggttac 3089581 acctgctctt gatatgaaga atagacagtt ggcaattaga caatacgata caaaaaataa 3089641 taataataaa cagtgggtga caatctttaa cctggacgat gcaatagcaa ataaaaacaa 3089701 tcctctttat actattaaca ttcctgacga acttcattat ttacaaggtt tctttttaga 3089761 tgacggttat ttatattggt atacaggaga tacaaacagc aaaagctatc cgaatctcat 3089821 aactgtattt gattccgata ataaaatagt gctgcaaaaa gaaattactg ttggcaaaga 3089881 cttgtccacc agatatgaga ataacttccg tgaaccggaa gggatctgta tgtacaccaa 3089941 tcctgaaact ggggcaaaat cattaatggt gggaattaca agtggaaaag aaggaaatcg 3090001 tataagcaga atttatgcat accattctta tgaaaacttc atgaatcatg tacctatgct 3090061 tcgatcccct ttattaaaaa ccgtggggca ccaagataca cctccagaaa gatttcaacc 3090121 atttattcaa accttcattt tagagtataa tgctcaaaac aaaaaatgga tggttccgac 3090181 ttcaggttat ttaccatctt acacatcaaa tttagtccga aatattacta tcaatgcaga 3090241 tggaaacttg caagtcacat taaatgaacg ctatattagt ttactgcatc aatcgataga 3090301 aggagatttc cgcttaaaac aaaaggatat ccgaatggga tcctggtatt ttgccggcgg 3090361 agaaaaatca aatgtgcttg aaataggttt tatgaaaggg agtacaaaaa tcagacccga 3090421 tgatgcagcc atctcaaatg cttcaagaat gagtattttt atgattgttg cggacaagat 3090481 tgaggtgtga taatcaaata ggctgtagct atttaatagc tacagcctat ttgcaacttt 3090541 ctaagttttt tatcgatatt ccggaacatc ggcctacttt atagaccagc ttctttcggg 3090601 gcaatatgca taaagaaaag actccagaga ttggagtctt tttcttttat tgcacccgta 3090661 tacttcctgc gtatttatcc ttccaatatg tgctcgtgtt catattggta atggtcacgc 3090721 cgtttgataa tgtgacatga acaacttgtc cgtttccgat atagatggag ggatttaagc 3090781 ttgttgattg aaagaacaca atgtctcccg gcttcaggtc cgccttctca atcttagttc 3090841 cggcattgta ctggcttgtt gcgtatcgag gcagggaaat accggctgct ttctggtata 3090901 catattggac aaatccagct gtatcaaatc ccgtctcagg tgttactccg ccctgtttgt 3090961 aaggcacttc tccgacataa agcgtcgctt cggaaacaat cggattttct ttcgggattg 3091021 tcaggttgtc aaatcggcga atacccgtca tcttcgattt ccagtaatcc tctgacaaat 3091081 aggaaatggt tactttttct gaccggcttg cctgaatgaa cctgcctgcg cccgcataaa 3091141 tgcctgcatg tgaaattccc gttttatacg tattgctgaa atagacgaca tcaccaggct 3091201 ttatgttctg aggggctacc ttctcgccca ctgcccactg ctgttcggct gatcgcggta 3091261 gataaatgcc gagtgcctgt tgaaacacat attgcacaag ccccgagcaa tcaaagccct 3091321 ctgacggcgt gcttccgcca aacacatatg ggacaccgat atatttttcg gcctcctgaa 3091381 cgacaggaac atcagccgtt gccggatcgg cagcgattcg tctcgccccg atataagttc 3091441 cgctccaata gctgcttttt ttgtaattgg tgatgataac cccttttgac tgtgtactgt 3091501 gaaccatttg gccgtctccg atataaaggg cgtcatgtgt cggaacagtg ccggtgcttc 3091561 cctctttctt gaaaaacaaa atatcacccg gcttcaggtt ttccggtttt acagctgttc 3091621 cgattttata ctggtcgttt acagatctcg gcagatgaat atcagcctta ctgaacacat 3091681 attgtatcaa tcctgatgga tcgaaaccct ctttcggcgt ttccccgcca tatttatact 3091741 gatatccaag caggtttttt gcttcgctga caatcaattc tgatgatgta tcagcttccg 3091801 caatctccgc ttttgtcata attggaacca aaaaacaaat gataaccgcc acaagcaaaa 3091861 acttcttcca gtttgccagt gtgttcactt ttattatctc ctcctctttt tgcagtttta 3091921 acatcggtat ttttttgaat atgttaagag actttttaat atttttacag aatgaatatg 3091981 ctgggcaaat aaaaagagag tgtctcatca gacactctct tttttgaatt atttattggc 3092041 gtttaccggt tcttcctgct gctggatttt attcatttcc atatcaatct tctgtttttc 3092101 ctgatctgtc agctgatcat tgaatttaaa agctgacata aacatgaaca cgatggctac 3092161 ggcaacaaac ggccagatgg ctttgacaaa tttcatcttt atcactccga ttatttagat 3092221 tttagtttgt cactatgatc aatatcaaac gtcagttttc cgtcttctac tttccaagcg 3092281 aaattagagt ctttcgtcag ttcgcgaata atggttttct gtttaaggct gtcttttttc 3092341 acaggcgcag gtgtcgcttc atggatatcg atcggtgtca cttcaaagcg tcctgttcca 3092401 tttttcttca ggtgatactg aaccagtgca ctgtctcttg ttctcgtcca gccttggtca 3092461 aagacaaagt tgccgaggct gtagaaaatg acggttccgt tatatacttc aatcggttct 3092521 aagacgtgcg ggtgatggcc gacgatgatg tcagctcccg catcagacat ggctcttgca 3092581 agctggcgct ggcggtcatt tggatcattg tcatactctt gtccccagtg tgactgcaca 3092641 acaacaatgt ccgcatgttt tttcgcttct gaaatcatag ggatgaagat ttcaggatct 3092701 gcgggcagca cgcccggcgt attcttttta gccgcgaaac ctttcccgga cacatcggta 3092761 aagccaagcg tcgcaatcgt taccccgttg actttctggt acgaaatttt ctttttcgca 3092821 tcacttaagc tgtatcccgc tccaacgata tcaagatttt gcttcgcaaa ttctccaagc 3092881 gtatctttca tgccctgaac gccgtaatcc attgcgtggt tgttggcgct gttgagaacc 3092941 gtgaaattca tatccttcaa gactttcact gattccttat tcgtctgcag atgaatctct 3093001 ttatctgctt gtttataatt cttttgatag gttaccgggt tttcaaagtt tcctgctaca 3093061 taatccgagg ctctaaagat cggttcaaca tattgaaaaa tactgtctgc ccctttttgc 3093121 tccgttactt tttcaacata gcgtcccatc ataatatcgc ctacaaatga ggctgagagt 3093181 acgtcgtcag aatacgtttt gaccttcggc gtttccgctt ttcccgccca catgaaagcg 3093241 aacataagga caaaaacgat cggaatggca ataaatacgt gcttattggt tttctttttt 3093301 tgctgttttg tcagctttag cagcttttca tgaaagctca gttctttttt catcgtttga 3093361 cacaccttac attaaattaa gtagtaaaca aacatgatag caaaggtcgc tccgctcaat 3093421 agcagcgtgc ttccgaacgt aatggttaaa ccttgtttct gaatggtatt ggcaattaaa 3093481 cctggcacga tgatgccgat tcctcgaaat tctgcgattt caaatggtac aatcgggtat 3093541 agaaaatcaa acgcgatttt taggacgatc cctgttatca gcatggcagc gaattttctg 3093601 cgtccgtaca aaatcataaa tttggataaa ccgtatttca caatgacata cgtgagcaag 3093661 ctcactagca aaacaagtaa aataaagacc ggctgattaa acacaagtcc taaatatccc 3093721 ggtacaacaa gtcctgccgg cacgatccct gttttttccg caaaaattaa actgagtagt 3093781 acacctaaaa ttagtgcgat gtataaatct gatccgaaca tgtctgcatt tccccctagc 3093841 ttacgagctg ctttaccttg tattcgtgga ttttttcaat taaaggctct gcggcaccat 3093901 gaatattgcc gacgccatat atgacacggt tgtgcattct tttctttaac aattccataa 3093961 tttcatctgt tgacttatac tctagatcat gcagtttgtc tgcaggaatt ttgccttctt 3094021 cgtaggcttt tacgatcggt tctgttgttt caccgattaa gatcagttca cttgcttcaa 3094081 tataaggcaa tacgtcattt gcgaattgct gtgtccgatc gacacggtct gcgcggcagt 3094141 tcatgatgat gatcggatca tcggtcgggt aaccgatttc ttttacacgt ttccatatat 3094201 tcaaagtaga agaagcgtcg tttgcggcaa acccattaac aaagtgccca ggctcgctcg 3094261 gactgatcag cggaagaatt ctcattgctc ccggatctgg cggcgcattc agcattccct 3094321 taaatgctgt ttcttcgtca atgccgagtg cttgagccac acccagcgcc agagaagcgt 3094381 tatcagggaa taccatgtat tcaaatttac gtaaatactc atctgtaatt tttgagttat 3094441 cagcaatgat gacttttgtg tttcgttctt ttgctttttg tttaaagaac tcggtatatt 3094501 cactatctgt aatgacaaga tggccattat aaggaattgt agcagtaaac gcttctgcaa 3094561 tttcatcaag cgtcggcccc atgacatcca tatggtcttc caaaacattc acaatgacgc 3094621 cgatattggc ctgcagaagt tcttcctgaa agatgatttg ataatctggg ttaacagcca 3094681 tgcattcact gacaatcgcg ttagcccctc tttctactgt ttctctcatg acttcttttt 3094741 gctctccgat attcggcccc tgaggtttcc gtttaatcgg cttttcctcc ggtgtgtccc 3094801 agtaaatcat tcttgcatct gttcctgttg tttttccaac agtcttgtaa ccggcttcta 3094861 ttaatattcc ggttgtcagc cttgtcacag tcgattttcc gcggatgccg ttaatattca 3094921 cccgaacagg gagggcatca atgtttttct gatgtcgtcg tttttctaat attccgatga 3094981 ccagtatgac agcacaggct ataatgagta accacattgc ttttcgacat ctccttctat 3095041 attgttgtaa attcattcat cagtatatag aatcactatg aattctcaat cggcattatg 3095101 taacataatc ttccctaatc gactaagcca aacttctctt ttgaaagaga ttttatacct 3095161 acaaactgtt ttctattttt ggaaaacagc aggacttata ccttatcact ttttaaaaaa 3095221 atcaaagaga atgcgctttc atttttctcc tgatatcctt ctggacgtat agtcacaccc 3095281 tgctgtttgt atttaatatg catttcaaat caatcttttt ttcagccttt gttatcaagc 3095341 atttcctgct atcatgcgtg tttccggttc ttatgaacac aaaataattt tatcctgttt 3095401 cttaaggaca aggtcataat gtcatccttt ctgcatggaa taagcaatat gaggcccatt 3095461 ccaaaatgac taaggaggtt cgagatgaaa acgctaaaca tacgagtccg aattctctaa 3095521 cataattaaa cattttctgg gatgatagtc ttttctgttt ctccccattt acaggtctaa 3095581 acgcatgact ttgaaacaat tttaataaaa cttaatattt gttcaagaaa tcttcatcca 3095641 tatttgtgaa gactttgtca aaaaaagagt gaaaacctta aatttttcaa ttatatatac 3095701 aatttacaat tagatttctt ttgatatttt tattgctaac ttcggattgt tcatgataat 3095761 ctatctatgt aaacggttac ataaacaagg aggagctgtt ttggctacaa ttaaagatgt 3095821 cgccggagcg gcgggcgttt cagttgcgac ggtttcccgc aacctgaatg ataacggcta 3095881 tgtacacgaa gaaacgcgaa cgcgtgtcat agcggcgatg gcgaagctga actattaccc 3095941 gaatgaagtc gccagatctc tatataaaag agaatcccga ctgatcggac ttttgctccc 3096001 ggatatcaca aaccctttct tcccccagct tgcccgcggt gcggaggatg aattgaaccg 3096061 ggaaggctat cgccttattt tcggcaacag tgacgaggaa ttgaaaaaag aacttgaata 3096121 ccttcaaacc tttaagcaaa atcatgtcgc aggcattatt gccgcaacga attacccgga 3096181 tctcgaggaa tacagcggca tgaattatcc agttgttttt ctggacagaa cgcttgaagg 3096241 ggctccttct gtgtccagtg acggctatac aggagtaaag ttagccgccc aggctatcat 3096301 tcacggaaaa agccagcgca ttacgctctt gagaggaccc gctcacctgc cgaccgctca 3096361 agaccgattt aacggcgctt tggaaatctt aaagcaggct gaagttgatt ttcaggtcat 3096421 tgagacagct tcattttcaa ttaaagatgc acaatcgatg gcgaaggagc tgtttgcctc 3096481 ttatccagcg acagatggtg tgatcgcgag taatgatatt caagccgctg ccgttttaca 3096541 tgaagcattg cggcgcggaa aaaacgtgcc ggaggacatt caaattatcg gctatgatga 3096601 cattccgcaa agcggacttc tgttcccgcc actttctaca attaaacagc ccgcatatga 3096661 tatggggaaa gaagctgcca aactgctttt gggtatcatt aaaaaacagc cgctggcaga 3096721 aacggcaatt caaatgcctg tcacctatat aggaagaaag acgacaagaa aggaagatta 3096781 agatgcgtaa tatttgtgtg attggtagct gttctatgga tttagtggtc acctcggaca 3096841 aacgcccaaa agccggtgaa acggttcttg gcacgtcatt tcagactgtg ccgggcggca 3096901 aaggagcaaa tcaggccgtt gccgcagcca gacttggggc gcaagtgttt atggtcggca 3096961 aagttggaga cgatcattat ggaacagcta ttttgaataa tctcaaagct aacggcgttc 3097021 gcactgatta tatggaaccg gttacacata cggaaagcgg aaccgctcat attgtgcttg 3097081 ctgaaggcga caacagcatt gtcgttgtca aaggcgcgaa cgatgacatc accccagcgt 3097141 atgcgttaaa cgcgctcgaa cagattgaaa aggtcgatat ggtgctgatt cagcaggaaa 3097201 tcccagaaga aacggttgat gaggtgtgca aatactgcca ttctcacgat atcccgatca 3097261 tactaaaccc agcaccggcc cgcccgctca agcaggaaac aattgatcac gctacctatc 3097321 tgacgccgaa tgaacacgag gcttcgattt tattccctga gcttaccatt tccgaagctc 3097381 tggcgcttta tccggcaaag ctctttatta cggaaggaaa acaaggcgtc cgctattcgg 3097441 ctggcagcaa agaggtgctc atcccgtcct tccctgtaga acccgttgat acaaccggag 3097501 ccggtgatac gtttaacgca gcatttgccg tggccctggc tgagggaaaa gacattgaag 3097561 ccgcattgcg gtttgccaat cgtgccgctt ccctttctgt ctgctccttc ggtgcccaag 3097621 gcggaatgcc gacaagaaat gaagtagagg agctgctgtc atgaaaaaac acggtatact 3097681 gaacagccat cttgccaaga ttttagccga ccttggccac actgataaaa ttgtcatcgc 3097741 ggatgccgga ctgccggttc ctgacggcgt tttgaaaatt gatctttcac tgaagccggg 3097801 ccttccggct ttccaagata cagcggcagt actggctgag gaaatggcgg tcgaaaaagt 3097861 cattgctgca gctgaaataa aagcatccaa tcaggagaat gcgaaatttc tagaaaatct 3097921 tttctctgaa caagagattg aatacctttc tcacgaggag tttaagctgc tgacaaaaga 3097981 tgcaaaggca gtcataagaa caggagaatt cacaccatat gccaactgca tcctgcaggc 3098041 aggtgtactt ttctagaaag gaagatgaaa catgcagatt gaaatgaaag acattcataa 3098101 aacattcgga aaaaatcagg tgctgtcagg cgtttccttt cagctcatgc ctggcgaggt 3098161 tcacgcatta atgggagaaa acggcgccgg caagtccacg cttatgaaca ttttgacagg 3098221 cctgcacaaa gcagataaag gtcaaatcag cataaacgga aacgaaacgt atttttccaa 3098281 tccgaaagaa gcggaacagc atggaatagc ctttatccat caggaattga atatctggcc 3098341 ggaaatgacc gttcttgaga atctatttat cggtaaagag atatcctcca agctgggcgt 3098401 tttacaaaca agaaaaatga aagcgctagc aaaagagcaa tttgacaaac tttccgtctc 3098461 tctttctctt gatcaagaag ccggcgaatg ttccgtcgga cagcagcaaa tgatcgaaat 3098521 tgcaaaagcg cttatgacaa atgccgaggt aatcattatg gatgaaccga ccgcagcgtt 3098581 gactgaacgt gaaatcagca agctctttga ggtcattaca gcgttaaaaa agaacggcgt 3098641 ctccattgtc tatatttcgc atcgcatgga agaaattttt gcgatttgcg acagaattac 3098701 catcatgcgt gacggaaaaa cggtagatac aacaaacatc tcagaaactg attttgatga 3098761 agtcgtcaaa aaaatggtcg gacgggagct gactgaacga tatccaaaac gcactccttc 3098821 tctcggtgac aaagtattcg aggtgaaaaa tgcttccgta aaagggagtt ttgaggacgt 3098881 cagcttttat gtgcgttccg gtgagatcgt cggtgtttca ggattaatgg gagccggccg 3098941 gacagaaatg atgagagcgc tgttcggcgt tgacaggctg gacacgggtg agatatggat 3099001 cgctgggaaa aaaacggcta ttaagaaccc gcaggaagcc gtgaaaaaag gtctcggctt 3099061 tattacagag aatcgcaagg atgaagggct cctgctcgac acctcgatcc gcgaaaatat 3099121 tgccctgccc aatctgtcca gcttctcacc aaagggtctc attgatcata agcgggaggc 3099181 tgaatttgtc gatctgttaa tcaagcgcct cactatcaaa acagcatcac cggaaacgca 3099241 cgcacgccat ttatcaggag gaaaccagca aaaagtggtg atagccaagt ggatcggcat 3099301 cggaccgaaa gtgcttatct tggatgagcc aaccagaggt gtggatgttg gcgccaaacg 3099361 agagatttat acgctgatga atgagctgac cgaacgcggt gtcgctatca tcatggtgtc 3099421 atcagagctt cctgaaattc tgggaatgag cgatcggatt atcgttgtcc atgaaggcag 3099481 aatcagcggc gaaatccatg cgcgagaagc aacacaagaa cgaattatga cacttgccac 3099541 gggagggcgg taatatgaaa acggaacaac tgcaaacaga acaaaaacgg attcacttcg 3099601 acggagtcat gcaaaaactc ggcccgtttc ttggtttatt tattctcgtt atcattgtat 3099661 ctattttaaa tcccagcttt cttgaaccgc tgaatatttt aaacctgctt cgccaggtcg 3099721 ccattaacgg attaatcgcg ttcgggatga cctttgttat tttgacaggc ggcattgatc 3099781 tttctgttgg cgctattctt gccctgtcca gtgctttagt tgcggggatg attgtgtccg 3099841 gtgtcgatcc ggttctcgcg atcatccttg gctgtatcat tggtgccgta ctaggcatga 3099901 tcaacggatt attgattact aaaggaaaaa tggcgccctt tatcgccacg cttgcgacca 3099961 tgactgtgtt tcgcggactg acgctagtgt atacagatgg aaatccgatt accggacttg 3100021 gcacaaacta cggttttcag atgttcggac gcggttactt tttaggcatt cctgtaccgg 3100081 caattacgat ggttcttgcc tttgtcatcc tttgggtgct tcttcataaa acaccattcg 3100141 gacgccgaac gtacgctatc ggcggcaacg aaaaagccgc gctcatttca ggcatcaaag 3100201 tgacgcgcgt gaaagtgatg atctattctt tagccgggct tttatccgct cttgcaggtg 3100261 ccatattgac ttcccgcctg cattcggccc agccgactgc gggagaatcg tacgaacttg 3100321 atgctatcgc ggcagtcgtc ttaggaggga caagtctttc cggcggccga ggacgcattg 3100381 tcggcacgtt aatcggggtg ctgatcatcg gcacacttaa taacggactt aatctgcttg 3100441 gcgtctcatc attttatcag ctggttgtca aagggattgt tatcttaatt gcggtattgt 3100501 tagaccgcaa gaagtcagct taggagggtt ttacatgaaa aaggctgtat ccgtcatttt 3100561 aacgttatca ttatttttgt taaccgcctg ttcgcttgag cctccccaat gggcaaagcc 3100621 atcaaactcg gggaacaaaa aggaattcac cattggcttg tccgtctcaa cgcttaataa 3100681 tccttttttt gtctcattaa aaaagggtat cgaaaaagaa gctaaaaaac ggggaatgaa 3100741 agtcatcatt gttgatgcac aaaatgattc atcgaaacag acgagtgacg tggaagattt 3100801 aattcagcaa ggtgttgatg cattattaat caacccgact gattcttcgg cgatctcaac 3100861 ggcagtagaa tctgcaaacg cagtcggtgt gcccgtcgta acaatcgatc gatctgcgga 3100921 acaaggaaaa gttgaaaccc tcgttgcttc cgataatgta aaaggcggtg aaatggccgc 3100981 ggcgtttatt gccgacaaac ttggaaaagg agcaaaggtg gcagagcttg aaggcgtccc 3101041 cggcgcatct gccacacggg aacgcggctc aggattccat aacatcgcag accaaaagct 3101101 ccaagttgtc acaaaacaat cagctgactt tgaccgcacg aaaggcctga ctgtcatgga 3101161 aaacctgctg cagggacatc ctgatatcca agctgttttt gctcacaacg atgaaatggc 3101221 gctcggtgct ctcgaggcaa ttaacagctc ggggaaagac atattggtga tcggttttga 3101281 cggcaataaa gatgcgctcg cttccattaa agacagaaag ctgtcagcca ccgtcgctca 3101341 gcagcctgaa ttaatcggta aattggctac agaagcagca gatgatattt tgcacgggaa 3101401 aaaagtgcaa aaaacaatat ccgcgcctct caaactagaa acacaaaaat aattgtctga 3101461 tgtttaggaa cctgcgataa cgtgaataga gatatagaat gaattatttc tcttacgtga 3101521 ggagaggaac ggcatgaaca aaccaacaaa actattttca acattagcac ttgcggctgg 3101581 aatgactgcg gcggctgctg gcggcgctgg cacgatccat gctcaacagc cagaaacaac 3101641 ggtaagcatt gatgatttat acagttatcc gattgattct tatttggtat cagcagaggc 3101701 tctaaatgtc agaacgaagc cttccgcatc aagccagaaa gccgatacgc tgcacttagg 3101761 agatagccta aagctgattt ccttctcaaa tgctgactgg gcaaaggtta agtataaaaa 3101821 tggaaaaaca ggatttgtat ccactcatta cattgttaaa gcagcgacaa cggtaaaaac 3101881 caaaacaaaa acaaaagtgt atacatccgc tgacggaaag agcattaaga ctcttccagc 3101941 agacacaagc gtttcttttt taggctggag taaaacgaat aaaggcggtt ttgattttga 3102001 ttgggtattc gttgattacg gcggtacgac aggttatatg aaaacaaagg atttacacat 3102061 gacaaaataa ctgagaggga ttccgcataa atgcggaatc ccttttatta tgaattgatt 3102121 tgtcacattc ccaagatatt tctcaggaaa tattgtcgta tgctgtgtcg aaaccttaca 3102181 tgatcatcga catttttgtt cacgctaaaa agcggaggtg taaatatgga tcaatttgaa 3102241 gcagcatatg aatcgtataa agcccggcaa acaactgccg atcaagaaaa tgttccatct 3102301 ggaaaagaag aaattattgc ggttagaaga aatgaggaag acaatattat cgcagtgaaa 3102361 accaatacag gaagagagct cgactaccct actgcgctgt cagaagcaaa atcaggaaaa 3102421 ctcgctcatg ttgatgtctt ccataaatac gggcgtgaca ttttgcgaag tgaaccggac 3102481 ggcatcaagg aaaataacct gtctgagctg ccggattttt aaacaaatac agccctgccg 3102541 tatgttggac agggctgtat tttaaacaaa aggctgctgg atgtattcgg ctaaccgttt 3102601 tgcactgtga gaaatatcct ctgcagctgc ataattcacg ccatagaaca catatggagg 3102661 cagatacttc atgccgatca gattactcgt ggcctgaaat ggtttcaata gctcactgat 3102721 cgagtaatga tttgctccgc ccgcttgata tttttccgct tcgctccctg ttgatacagc 3102781 cagcatcagc tccttgccat gcaaggcatt tccttctgaa ccaaaagccc agccataagt 3102841 cagcacaaga tcctgccatt ttttcaagag cggcggagag ctgtaccaat atagcgggaa 3102901 ttgaaagaca atccgatcgt attcctcgca cagctgctgt tccttcgcaa catctatcgc 3102961 ttcatccggg tattccttat aaagatcccg tactgtgata ttgtcatgtt tactcaattc 3103021 ctcagcccac gccttattaa caactgaggt ctccatatga ggatgcactg ccaaaaccaa 3103081 tattttcatc agaccacacc tttactgttt tgatgttatt ttatctaaaa tcaggaaaag 3103141 agccaaataa aaagaaagcc ctgctaaaag gggctttctt tttttctttt attcagggct 3103201 tccttcagtt gtttcgatat ctttcgcaaa atcagggtta tccagattcg cattaaagaa 3103261 atccgctgtg ttcggaagtc tgagattcat gttcattttt tgagaaatcg taaccgtgca 3103321 atcctcaagc acatagtcaa aaacgtgtcc gcctgaattg cgtccttcgt caatgaagtg 3103381 caggtgatag ccagaaacgg cgattccgtt tgcataagct ggtgtcaaga aacctacaat 3103441 cgttcctctc acgttgtcga agttgaaaat cggctgtgtt ttgaccgctt caaccattgg 3103501 cacgtaaggt ttttcttgaa gttctactgt tcttgtctgc acctttttaa acaatccgtc 3103561 aatgcgaatt gcataaaata agtttctgct tggcagcatg ctgttgatct ctttttcaaa 3103621 gtcttcgcgt gtcattttcg catcaatttt gtgcgtcatg tccggtgtaa agaacgtaaa 3103681 tgaacagaac ggtgaacggt ctccattttg gaccggtgtc gcggttccgt ctgagcgaag 3103741 acggtaaaat tcgccgtcaa acccaatcag ctctccgtca agcttgttaa aggttccgat 3103801 accgaagtct ccatatttcg gaatctctga cagttcaaaa tctccgtcat atactccgtc 3103861 taatagagaa gtcattgttg atacttgata aatctggctc acaggctgat ctttttgacc 3103921 acggctgagc acttgaatgt tgctttctcg tttcatattt cccttcactc cttttattta 3103981 gtgctgttca taaaacagtg tcgtgatgcg cagagtgcta gagagctttc gttttcatga 3104041 gttccccgaa ttctttcgga agcttgtcac ttgctaaatt aatgttatca ctgtagtcaa 3104101 ccgggacatc gatgatgaca ggaccttcag cgttcatgcc ttgacgcaga acatctgcca 3104161 gctggtctgg tgattctacg cgcaagccag ttgctccgaa gctttccgca tatttcacga 3104221 tatcgatatt tccgaaatcg accgcagatg tacggttata ttttttcaat tgctggaatg 3104281 caaccatgtc atatgtgctg tcgttccata caatgtgtac aattggtgct tttagtcgaa 3104341 ctgctgtctc taattccatt gctgagaata agaaaccgcc gtcaccagag acagaaacca 3104401 ctttttctcc cggtttcacc aatgaagcgc cgattgccca aggaagcgca acgccgagtg 3104461 tttgcatacc gttactgatc attaatgtta acggctcgta gctgcggaaa taacgtgaca 3104521 tccaaatggc gtgcgaaccg atatcgcaag ttactgtaac atgatcatcg actgcattac 3104581 gcaactcttt aacgatttca agagggtgcg ctctgtctga tttccaatct gcaggcacct 3104641 gctcaccttc atgcatatat tgttttaaat cagaaaggat tttctgctca cgctctgcaa 3104701 attccacttt cacagcatcg tgttcgatat gattgatcgt ggacggaatg tcaccgatca 3104761 attcaagatc aggctggtaa gcatgatcaa tgtcagcgat aatctcgtct aaatggataa 3104821 ttgtccggtc tccattgata ttccagaatt tcggatcata ttcaatcggg tcatagccga 3104881 tcgtcagaac aacatctgcc tgctctagca gtaaatcgcc aggctggttg cggaacaaac 3104941 cgatacggcc aaaatattga tcctctaaat ctctagaaag ggtaccggca gcttgatatg 3105001 tttcaacaaa tggaagctga acctttttca aaagcttgcg aaccgcttta attgcttccg 3105061 gtcttccgcc tttcatgccg accaaaacga caggaagttt tgctgtttgg atttttgcta 3105121 tggccgcact gattgcatca tctgctgcag gaccgagttt tggcgctgca acagcacgca 3105181 cgtttttcgt atttgtgact tcattcacaa catcttgcgg aaagctcaca aaagcggccc 3105241 cagcctgccc tgctgacgct atcctaaatg catttgtaac agcttccggt atatttttta 3105301 catcttgaac ttctacactg tattttgtaa tcggctggaa tagcgccgca ttatccaaag 3105361 attgatgtgt ccgttttaaa cgatctgcac ggatcacgtt tccagcaagc gcaacgacag 3105421 ggtctccttc agtgttcgct gtcagcaggc ctgttgccaa gttagaggca cccggtcctg 3105481 atgtgactaa cacgactccc ggttttccag ttaaacggcc gactgcttgg gccatgaatg 3105541 ctgcgttttg ttcgtgccgg gcaacgataa tttcaggtcc tttatcttgt aaagcgtcaa 3105601 ataccgcatc aatttttgca cctggaatgc caaatacatg tgtgacacct tgctccacta 3105661 agcaatcaac aacaagctcc gcccctctgt ttttcacaag ggatttttgt tcttttgttg 3105721 cttttgtcaa caccctcact ccttattatg cattttaaac gtaaaatttt aaatatcttg 3105781 tgataagttt cactatacac tctttggaaa ttgacctcca atatcgattc gccttatgat 3105841 taatatgtaa tacgaattat taacctatgg aaaggaatgc atattgaatg gagcttcgcc 3105901 atcttcaata ctttatcgca gtagccgaag agcttcattt cggaaaggct gcccggcggc 3105961 tgaacatgac gcagcctcct ctcagccagc agatcaaaca gctggaggaa gaagtcggag 3106021 ttacgcttct gaaaaggaca aaacgatttg tcgagcttac cgcagcagga gaaatctttt 3106081 taaatcattg ccgcatggca ttgatgcaaa tcggacaagg aattgaactg gcacagcgga 3106141 cggcccgcgg cgagcaaggc cttctcgtaa tcggttttgt cggatcagct acatatgaat 3106201 ttctgccgcc gattgtccgg gaatatcgta aaaaattccc atctgtgaaa atagaactgc 3106261 gtgaaatatc ctcgtctagg cagcaggagg agctactaaa gggcaacatt gatattggta 3106321 tacttcatcc tcccttacag catacagctt tacatatcga aaccgcccaa agcagccctt 3106381 gtgttttagc tttgcctaag caacacccat tgacttctaa ggaatcaatt acgattgagg 3106441 atttaagaga tgaaccaatt attactgttg ctaaagaagc atggcctact ctatacatgg 3106501 attttattca gttctgtgaa caagcgggct tcagacccaa cattgtccag gaagccacag 3106561 aatatcaaat ggtgattggt ttagtcagtg ccggaattgg tatgacattt gttccttcct 3106621 cggccaaaaa attatttaat ttggatgtta cttatcgaaa aatggaccaa atacagctta 3106681 atgcagaatg ggttatcgct taccgcaaag acaatcataa tccgcttata aagcatttta 3106741 ttcatatttc aaattgtcag cagacaagaa ctaaagagag tgatgcaggt acatgaacaa 3106801 tacttgcaat ctcttttttc ttttgggatt cttatggaat ttttattaat ttaatataat 3106861 cgcttagtac aactttatat cagtatacgt atacatacag tacaaatagt tggcaaggac 3106921 atcagtaagc gcaggacatt agtttgattt taaaaatgaa agatagagag gtgaagtaaa 3106981 ttattgagtt caccggcata ttcacattgc tcgctttttt cgtaacaatg atttttattt 3107041 tctggagacc aaaaggacta aatgaagcta tccccgccac atttggcgct ttaatggttt 3107101 tattgtgcgg aagtgtgtca ttggcagact taggggaaat cggaacaaaa gtcacgggtg 3107161 catcggttac aatccttgcc actatgatta tggccattgc actagaaagc tttggtttct 3107221 tttattgggt ggctgcaaaa ctgctccaac aatccaaggg ttcaggcatc aagctttttt 3107281 ggctaaccaa tttgctctgc tttctcatga ccattttcct taataatgat gggagcattt 3107341 tgatcacaac tccaatcctt ttgcttgtac taaaatattt aggtttaaaa aaacatcaaa 3107401 aagccccata tttattaagc ggtgttttaa tagccacagc ctctagcgca ccgattggcg 3107461 taagtaatat tgttaattta atttctctca aaatcattgg aatggatcta tatcttcaca 3107521 ccgccatgat gtttgtccct agtatgatgg gactcatttt tatgacttgt ctactgttta 3107581 tgttctttta taaacgtctt cccaaaagcc tgccagatat accgggccat tttcagtctc 3107641 tgcggcatag aaggtaccat cctcttcatt cgccatcagc tcctttacca gaacgaaatc 3107701 aaacaaaaat catgttgttt gtgcttgcat ttgtttttct cgtcagaatg agtctatttg 3107761 cagcatcata taccggtatt tctgttcctc tagtcgctgt catcggatct tttatcctgt 3107821 tgagctggag atggatttat ttcaaaacct ccccaagaga cttgttatat aaatcgcctt 3107881 ggcacatttt tatattcgct tttactatgt atgtcttaat ttatggtctg cataatattg 3107941 gattcacaga gttacttgtg agttattttg aacctgtggt ttctggaagc ctcgcccatg 3108001 caactttcgc atcaggtatc tctacttcag ttttttctaa tctctttaac aaccatccag 3108061 cgttaatgat cagtactttt accttaactg aaatgaccct gaatccttca acaacaaaaa 3108121 tcatctactt ggcaaatatt atcggcagtg atatcggttc attattatta cctatgggaa 3108181 ccttagcaac gcttatttgg atgcatatat taaaacagca tgatgaaagt atttcatggg 3108241 gcgaatatat aaaaacgacc attatcatca ttccgctgac tgttcttttt acgttaacat 3108301 gtttatattt ttggatcagt tggttatttc tttagcacag tatgaaacga aaaactgcct 3108361 tctgcttttc aagagggcag ttttgtatac actagggaag atgcattgtc tttagatgat 3108421 ttaacttcca aatgactggc tctccacttg cgttaataag ctcaatgata ttattagaga 3108481 caccctttaa tagtccgact ttttctggca cctctcccat atcaaatatg accaattcac 3108541 caatattttt tttgatctgc tcctcaaaat tacgcacaag aggaactttg gaaggcacga 3108601 ccggcaattg tgagttgtca agagtatacg gtgtttgttc agttgaataa ggggtaaacc 3108661 attttaaatg atgcatagat ataaaaagta ttttaaatac gggtgagaaa aatacaatat 3108721 aatcgtttaa aacatttgta acatatccat ggatcgatcg acccccagtt acataaactt 3108781 caataaactg gcctttgacc ttgtttaatg tatttctata tgaaaaagct tgagtttctg 3108841 cctctatcat tggatcttcc ggattgatca aaaatggctt ctcagtactg gtcactattt 3108901 tcgccttgtt tatttgatga agatgcaaca agggaatata aagataattg cagccatcaa 3108961 aaataacaaa aatatcctgt ccgatatcta tgagggtgcc gacaaacctt gtatctcctg 3109021 aaatgacaac ctcaacatct gtgttaagga attgattcaa acctttcacg attctcctcc 3109081 tttaactgaa aaagggcatc actttatctg atgctcctcc attatctatt aaaatttacg 3109141 tttccagtga tagtctatcg ttctgacaat cgtttcatag ctataatctt ccttttgttt 3109201 tcctgaactt tttattgaac ttgaatagcc tggtgatctt gatgattgat aatctgaaga 3109261 tcttggtgat cgtttagatg attttgatga ttgataatct gaagatttta atgatcgttt 3109321 agatgatttt gaagaacttt ttgaacgtga cgaacggcca gatttggatg attgataatc 3109381 cgaagatttt agtgatcgtt tagatgattt tgaagaactt tttgaacgtg acgaacgacc 3109441 agatttggat gattgatcat ctgaagattt tagtgatcgt ttagatgatt ttgatgagct 3109501 atatgatttt gaagaaatga acgaattgct gtccttatca ttattgtctt cctggttttg 3109561 ttcatttttt tgatcctctt ttttgtacga cccttttgga cctaagctga tgctttttat 3109621 gtgaaaagga tagatgcgaa gcacctcttg atttttcact atagtataat ggccgtcggc 3109681 attatctaca aggataccct caatggcttc cggacctcca cgattaattg aaacccattt 3109741 atgagtcaga ctcttaaaaa cctcgcttaa atcatcagct tccaaaactc caactggcgt 3109801 ctgctcttct attttcaaat caggctcgtg tttacttata cttttgatgt gatggatatt 3109861 aaaatacact accccatcct catttgtgtt taacgcagcg taatcatctc ccagccagac 3109921 caatcttcct tttttagatt ccggaccccc ttggttaaat tgaactgatt ggtttattaa 3109981 atgtccgatt aagctatgaa aatcatcagc atcgagcatt tcctcagtct caattgttgt 3110041 ggtgctatta ttggtatcct cagtaatact tttcacatgc tccaactgat aataaattat 3110101 ttttttttca gcttgtaaag ctatataatc tgattttaca gctgttaatt ttcctttttt 3110161 agattccgga cctccacgat atacagtaac aattttatct ttcattgagt gcaaaaagtt 3110221 ataatacgat atttcattat ttgaatgata tttcattctc ctcttgctca ttcaaattcc 3110281 tcctagtcac ttatacatag atgataaaca tactgcatat atacgtgtca catttatttg 3110341 ttgaactaat tcaatagcct aattgtcgct ttttccgcga atacccattt tcacgcattc 3110401 ataaaatact taaatgatct ttgaggtatt gtgaacggtt tttaatatac tcgcagatca 3110461 catccggctc acggtcaaaa cgctcaatat cattcttttt atacgggtcc atgaggacaa 3110521 acggcctaat ccgttcatac atcgccatga ttttcggttc catatattct attgtaaaaa 3110581 gagattggag cgttttttct aacaggcgct tgtaggactt gcgaaactcg gattcatcca 3110641 atatccgggc ggttagtgta ttaaatcctt gaattcttac ataatcggca gccatccgct 3110701 ctccatggat atccctgccc caagtcgcat cataatccca aggaatcacc tcaaataatc 3110761 cggtttcccc gcttctgtat aatgcgtagt tgtggacaaa cccgtcatag ttcgaggtga 3110821 atacaatacc agcaagccag cgcaaatact tatcgacatc cacgtgtttt gtcacttctg 3110881 acttaaactg agctttaggg accgtattaa ttttaaaaat catatcttgt aaataaaaat 3110941 catcttcctc agtccctgtt ttcttttcat atccaagctc cagcgatgtt ttcgtttccc 3111001 tttctaaatc gctcatcaga gaaaagttgg catcatcatc caccgcataa aaaatcgcgc 3111061 catcagccag cttccttttc gccaaataat attcatctac ggattcaagt tcaagataaa 3111121 ccccttcatt cttcccattc atctttacaa acgcaaactc tgcctttgga gacagtgtcc 3111181 ctagctccga gaaaaaatcc agagacaatt tgtttctcat caaggaaggg tctttatact 3111241 ccgcatttaa gtgaatctct cgcgcgccgc ggaatgtttt cggctgataa aaggaaatat 3111301 ggtatgactt ctttttgaag tctctgatat gtgatccccg ataagcgata tcaatatcca 3111361 gccttttttg atttaccttc atcacagctg gcaccggatc atcgtcccat atatcctttt 3111421 ttaattcacg caagtctttt ggatgaacaa acagctgata aagcggtaaa ttggattgat 3111481 tcttcatcca taatcctcct tacaaatttt aggcttttat ttttataaga tctcagcgga 3111541 acacttatac actttttaaa accgcgcgta ctatgagggt agtaaggatc ttcatcctta 3111601 acatattttt aaaaggagga tttcaaattg ggccactatt cccattctga catcgaagaa 3111661 gcggtgaaat ccgcaaaaaa agaaggttta aaggattatt tataccaaga gcctcatgga 3111721 aaaaaacgca gtcataaaaa gtcgcaccgc actcacaaaa aatctcgcag ccataaaaaa 3111781 tcatactgct ctcacaaaaa atctcgcagt cacaaaaaat cattctgttc tcacaaaaaa 3111841 tctcgcagcc acaaaaaatc atactgctct cacaagaaat ctcgcagcca caaaaaatcg 3111901 taccgttctc acaaaaaatc tcgcagctat aaaaaatctt accgttctta caaaaaatct 3111961 cgtagctata aaaaatcttg ccgttcttac aaaaaatctc gcagctacaa aaagtcttac 3112021 tgttctcaca agaaaaaatc tcgcagctat aagaagtcat gccgcacaca caaaaaatct 3112081 tatcgttccc ataagaaata ctacaaaaaa ccgcaccacc actgcgacga ctacaaaaga 3112141 cacgatgatt atgacagcaa aaaagaatac tggaaagacg gcaattgctg ggtagtcaaa 3112201 aagaaataca aataatctaa gttttcattg tttcaatagg ctgccggcgg aggtacggaa 3112261 gcctattttt ttatttgccc tgtattagat atatgtcatg acataacata tgcaacccgc 3112321 atcatttggt ttcctttaaa ccatttcgtt ataatcaagg tatcctaacg ataaaggcgg 3112381 ttgttgctat gtacatattt caagctgatc agcttagtgc caaagacaca tacaagctat 3112441 tgtcaggtac cgttattccc cgccccattg catttgtgac aacactttct tcaggaggag 3112501 cggtaaatgc cgcgcctttc agtttttata acgtcgtcag ctcagatcct ccgcttctca 3112561 gtatttctgt taacaggacg gaaggacgcc aaaaagatac agcacgaaac gcagtggaga 3112621 acggagaatt tgtcgttcat gtcagtgatg aagccatcat tgaagatatc aatgaaacag 3112681 ctgcaagctt aaggccggat gaaagcgagc ttacacgcac ctcgcttcat cctgttgaaa 3112741 gcaaagctgt ttcagttccc ggcattaagg aagcccgcgt tcgctttgag tgcaaattag 3112801 agcggcatat tacctttgac aatgatcaag gcatcactac agcagatctg ctcatcggaa 3112861 gagttgtctg cttccaccta gatgaaaagg tgtatgatgc agaaaaggga tatattttaa 3112921 cggatgaatt aaagcctgcc tcacgattgg cgggaaatca ctatgccaag ctgggggaag 3112981 aattcacact gattcgtccc agctgaagag aaggactatt taaatagaag aaactagtca 3113041 aaaagacctt atgattacaa aatatcgcct gtaaataact gaaaaaatat caaaaaaaag 3113101 aacacccaga gcaagctcgg ggtgttcttt tatgaaacgt ttttcctttt tcttcgtata 3113161 aaggtagatt aggaggaatt ggaatgacaa acttttggat tttaatgctg atcgctatta 3113221 ccatcagtct cgcctctcaa ttttttataa agaaaaaata cggtattgat aaatccggct 3113281 ggcgatataa gcatgtcagc aatacacaca aatggatcga aatcacttta cttattttgt 3113341 ttgtgttttc actctccttt tttccagttg aatatttgct tcttttattt tttattgtga 3113401 ttgactcaat acgtattttt atggagtggc attatagacc tgaagataaa cagtatatgt 3113461 accacattgt agaggtctcc cttatgttta tgcttttgat ttatgtttgt accctatagt 3113521 tatttaaatc cccacagccg ctccgtctcc ccgaggatcg gctccgcctt ggagaaagcc 3113581 ttcttcatca actttgattg cagccgcttg tcccatcagc ggatcatagt caccgacaac 3113641 ctccacgaga tgcccgctgt ctttcagttt ttggattgtt ttgtctgtga atctgccctc 3113701 gactctgaga ccttcgtatt cctctcccca cgttctgccc catacccagc gcggttcgct 3113761 gattgcctgc tgtggatgca ttccgtagtc cagcattcgg gtaatgatgg ccgtctgggt 3113821 ctgcggctgg ccttcgccgc cttgtgtgcc gtacagaatt tttggctttc cgcctttaca 3113881 gaccatagcc ggcatcaacg tatggaaggt gcgctttctc ggttcaagcg tgttgacatg 3113941 attttcatcc agtgagaaaa acgatccgcg gttttgcagt aatatgcctg tatcaccggc 3114001 agtgactgcc gagccaaatt caaagtacag gctttgaatg aatgacactg cgttgccatc 3114061 cgcatcgatt acggccgcat atgccgtatc acttcccacc ggcctgcttt ctgccggtat 3114121 tgcgagatag ccgatttctt ctgccaattg ttttgcataa cgtttgtcca aaagcctttc 3114181 aagcggaatg tctgcaaacg ccggatcagt caggacggca tcccgatcta gaaaactctt 3114241 tttcaatgcc tccacaagca cgtgataata ctcaaatgaa ccgtgttcga tttgggtgaa 3114301 atcatagttt tccaaaatgt tcagtgttaa taaaccggta aatccctgag aattcggcgg 3114361 cgcctgatac acactgtatc ctcgataatc acttgataca ggcgctgccc actcaccccg 3114421 atgcgcttta aaatcatcga ttgtcatgta actgccgtta ttctgtaaat gtgagacaat 3114481 ccgctgagcg agatctcctt cataaaatgc gcttcttcct ttttcagcaa tcaagttcag 3114541 actgtctgca agctcttttt gcacaaaccg ctctcccggg acaggtgctt tgccccttct 3114601 cgtgaagatg tcagccgtgt aaggcgtgga agccagcagt tcaatattct tttctgtgtg 3114661 acgacactga tcagctgata caggaaaccc attttgggca taatcgcgtg cgggctccaa 3114721 tacatctgca agagacagac gcccgtactc cttcaggacc gcatcccagc tatcaaccat 3114781 tcccggcacg gtaatagcac tgtcaattcc ccgcagcgga atcgcgcttt ttcccttata 3114841 tacatctctc gttacgtttt ttcctgaacg gccgctgcca ttgtagactt ttactgcctt 3114901 tgtttcctgg tgaaaggtca gccaaaagga atccccgcca agtccggtca tatgcgggta 3114961 cacaaccgca agacaagcac tcaccgcaac agcggcgtca aacgcgttgc ctcccttatc 3115021 cagtatgcgg tttccggctt gagaagcgag ataatgcgga ctgacgacca tttgctttgt 3115081 accgatgaca gatttgttca tcacaagtcc ccttttttaa gaaattttct tcagtatagg 3115141 gagcctgatt tttcacatct actgatccgg cagaaaaact gacgaacttt cttcttttcg 3115201 caaataataa gatattttcg cattcatttc gaaaacaaat gaaaaattat tatttctata 3115261 cgtaactttt atgataaaat gattgctaaa aggctacgaa agcaggtgga gcaattgagt 3115321 catgaatatc aaatccccaa ccttgtactt gatgagactg ataaacaaat tctcacgatt 3115381 ttgcatgaag aaggcagaat ttcttatacg gatcttggca aaagagtcga tttgtcacgg 3115441 gtcgccgttc aggcccgtat caaccaatta attgaagccg gtgttattga aaaattcacc 3115501 gctgtcatca atcccgctaa aatcggcatc catgtttccg tgtttttcaa tgtcgaggta 3115561 gaaccgcaat ttttagaaga ggtcgctctt aagcttgagg aagagcctgc ggtcaccagc 3115621 ctttatcaca tgacaggccc gagcaagctg catatgcatg ggatctttac caacgatcaa 3115681 gaaatggaag aattcttaac aaaacggctg tatccattgc gaggcgtcgt cagtgttgat 3115741 tgccagatgc tgatcaaacg atacaaaagc cgtatgggaa tgaagctgta aaggagagaa 3115801 acaaatgaaa aaccatcctt atcgggatat gacggccgca atggttcgca ccggcatatt 3115861 agggttcggc ggcggacctt ccgtgattcc gctgatccgc catgaagcgg tcaataaata 3115921 taaatggatt gacgatgatg aattcggaga aatattagca atcgctaatg cgcttcccgg 3115981 accgattgcc accaaaatgg ctgcttatct gggctttaag ctaaaaggca cattaggtgc 3116041 aattgtggcg atcctcgccc acattctgcc tacatgtctt gcgatggtgg gcttgtttgc 3116101 ggctgtaaat gtgttaagcc attcagcaat tgttgcaggt atgattggtg ccgtcacgcc 3116161 ggtaattgcg gtcatgctcg gaatcatggc gtacgagttt ggccaaaaag cgcttaaagg 3116221 tttcggctgg gttaccggca tcctgttttt tatcatcgct tttatcggcc tgcaaacttt 3116281 acagattaat cccggcctgg tcattatcat tttcttagct tacggggcgt ttcattttaa 3116341 actgaaagac aaaatcacaa ataaacattc aaaagataaa ggaatgtcag cctcatgata 3116401 tcgatctatt tatttatggc gttttttatc gcaaacctac tgggatatgg cggcggacct 3116461 gcgtctatcc cgctaatgtt tgaagaagtc gtaaacagat acagctggct ctcaaacgat 3116521 caattctcaa atatgctcgc acttgcgaac gcattgccgg gcccgatcgc cacgaaaatc 3116581 gctgcgtatg tcggctacag cgcaggcggg tggcccggct tcctaattgc cctgatcgca 3116641 accgtcgtac cgtcggcgct cgcattgatc gtcctgctgc gcatcatcca gcgcttccgc 3116701 caatcacctg tcatcaaagg catgacgctg tccgtccagc ctgtcatcgc ggtcatgatg 3116761 ctcattctta cctggcaaat cggcgcagac ggcatcaaag cgatcggctg ggtccaatcg 3116821 atcgtgatta cgggaatttc gctccttgcc atgacaaaat tcaaaatgca tccggcattt 3116881 ttgattattg cggcgttttt atatgggggc cttgtgatcc cttatttata gaaaaaagca 3116941 cctggacagg tgctttttta ttttagccca gaaatgccgt ttgatatgac agctgtttct 3117001 tctcctgcgt cactcttgat catgtgcttg acttgcagcg tggttcctgc cattctcaca 3117061 gattgcttca actgggacga attggtttca acttgtatcc aaacaggagg ctggaccttc 3117121 caaaataaat agagtgcaag aatcagcaag ccagcaatga ccgacagcaa aaacttcata 3117181 tcgcatcgct tcttttcagt aagcggctcg cagcggacag cgcctgatga tcacgaagaa 3117241 tatcgcctgg acgattgcct tctcccagca catagccttt aaaggacatt cccataaaat 3117301 gaaaaatatg ttcgaattgc tgaatcagcg gcagcccttt tatttttgga ttgtctccgc 3117361 ccactgctat tacatatgcc tgtttcactg acatttgctg tttaaaatca ggaaatctcg 3117421 gatctctcaa cgtctgtgac cagcgatcaa taaacagctt taatgtccct gacatgccaa 3117481 accaataaat tggggtggcg aatataagaa tatggcactg caatatccgt tcaatgatag 3117541 aatcgtagtc atcttgaaca ggacgaaagc cgccttgggc gtgacgcaga tcttcaattg 3117601 gttgaattgg atatttctgc aaataaatgt gctccgcatc gaatccttga acagccttct 3117661 ccgcaagaac atccgtattt ccgccagacc gagttccgcc gttaataacc gcaattttca 3117721 tgatgcatct gctcctttgt ttacgaatga ttttcttcat catataatgg attcatcaat 3117781 caatacagat gattatttcg attaatccaa tcgctaaaac cgatttagaa aggaagagaa 3117841 caagtggaat tgaagcagct gatcaccttt attacggcgg ctgaacatgt aaacttcacc 3117901 ctaaccgcca aaatgcttaa ttatgcacaa tcaagcgtta cctctcagat caaatcactt 3117961 gaagaagaaa tcggaacgcc tttatttgaa cggctcggca agcggcttat cttgacagaa 3118021 gcaggaaaaa cgttcaaatc ttatgcacag aagatcattg cgttaacaga agaagcgaaa 3118081 atggccacaa atcaagtaag agaaacaacc ggaaccttaa aaatcggggc gacggaaagc 3118141 cagtgcacat accgcctgcc ccctatcata aaagaattta aacaggcttt tccccaagta 3118201 aagctcatat tcaaaccata tatctccaat gaacaagcga aagaacagct cttacagggc 3118261 cagcttgata tcaccttcat cttggatgta aaccggatgg aagacgcact gcacgttgaa 3118321 tctttgattc aggatgagat caaaatggtg gctgctaatg accatccttt tcctgcggat 3118381 ttaccagtaa cattgaagga tcttcaaaac gaaactcttc tgctgacaga ggacggctgc 3118441 tcgtaccgca cgctctttga gaacaatttg catgactccg gtatctatcc taacaaattg 3118501 gaattcgtca gcatagaagc catcaaacaa tgcgtgatgg ccggacttgg gattggaatc 3118561 ttgcctgaaa tgacagtaaa agatgatatt gcagcaggcc ggatgaaaga actcaattgg 3118621 cagagcgatt gccccgtttt cactcaatta gcatggcata aggacaagtg gatgtctgcg 3118681 ccattaaagg cttttatcga tttgacacgg aaaacattca aataaaacct ctccacaagg 3118741 acgacaaggt ttttgagacc agggcacaca catacaaaaa aaacacttga tgacttagag 3118801 ccccaagtgt tacacgtgat ttttctgata aaacgttcgc aaaacatgcg tctcaaggtc 3118861 agccaggcgg acagggatcg gcagcctgct ttcttgattg atcaagctca tcgtgatctg 3118921 atagctgctg tctaaatcaa tataattacc gcaagacaag aaaataggct tcacgtcccg 3118981 ccgcgttcgc agcgcccgtc catatacctc gccgtcaatg ataatatcgg tgtatgcgcc 3119041 tacttcaatt tcaggcgtca cgaaatcgca gcctttgatt ttgagatagg ttttcgctat 3119101 cccaatcgtc ggcttgccca gaaaaaaagc cgcatgggtg gcaacgccca tatgattgta 3119161 atgcagatat ccgttgccat caaacaagaa gacatccggc tccgtctcca gctttttcgc 3119221 cgcctcgatg atcaagggca gctcgcgaaa cgcaagaaaa ccggaaacat acggcacgct 3119281 gattctcccc atgctgtgca ctttttcaat gacttctttt gtatcagcgt caattacgat 3119341 aatacagcac actccgtatg gttctccatc ctgctcccaa taggccaggt cgacgcctgc 3119401 gcaggtgttg atggagtctg gatggatcgt gggggatagg ttgatacgat ttttaaggtt 3119461 aaattgcact tgtaaaaagt cttgttcctt tttcatatca aatttatgca catcaaatac 3119521 cttcataacg attgctcact ctcgacctaa attaatgtga gtctctcttc tcgattctag 3119581 tatttcaaaa tgaggactat ctgtatctat ctcgtactta tttaatagat tgccttcttc 3119641 atcccaattc ttttcagaaa ttagtatgga atgctcatac tgttgctcac tttttttcct 3119701 gccattttca aaccaaatta tgcttatacc gtgcaattgc ccatatcggt attctttttc 3119761 acttttttta ttcccgtttt cataaaattc acatgttaaa ccatgggcca gaccattctt 3119821 atatttagta aaatagatga tttgaccatt tggatataat tcgtaagcca gccctgtaaa 3119881 cggctggcca ttttcgtctt caggattatc taaaatctca tcacttaccg aagagaacca 3119941 taaatcctca aagtccactc ccttttcttt tatactcttc atatcatatt cattttccat 3120001 actttaaagc ctccggtata taatttgtat tttgagttat atattcacaa tgtggacatc 3120061 taggcattgg gacaccttct ggcatctttt tatttatttt cctagcactt actacatata 3120121 ccattaaatc ttttaaatcc gcatcaggtc tttgaagtaa cgcttcattt agagcattaa 3120181 cttcggcatg agaacccgcc cctgacgtct ttatataacc ttctttaagt tctgtaggca 3120241 tatttacaat tctatcatga ataagtggat gtagtacctt aggtggcttc ccatctatat 3120301 tgtttattcc aaaataataa ttgcctgttt ttttgtccaa tacaccagct accgcagggc 3120361 ctctttgttt tttagttaga ccagaagatt taattctact aagttcgttt agtacttctg 3120421 cccttagatt tattcgatgg tgaagatctt ctttagacaa tacaccatgc ttatttctta 3120481 aatattgaag cctagtttgt ttttcttcag tagtcttagc aatattgcta ataaggcttt 3120541 cattactcac tttattgaca tatggagcat ttttttggta caaccgatca aagtagtgtg 3120601 ccaatcctgc tccaccaata atagtaatag cttccagcgc cccttgcttc cgcttctcct 3120661 cagacacttt gtttccgaac atatcccggc ctgtgacagc ttctgagaat ccgtttgacg 3120721 caacaaggcc gtatgcgccc atttctgtca ttttgagaat gtctaaggat ttgcctgttt 3120781 tgtaggcgtc taatgcgtgt tcagcagcga tagctgcttt tccggttttg tagatggctt 3120841 ttccgccttt gaaggcccgg cctgcccagc cgacgactgg tatgaatccg gcagcggcca 3120901 tagctcctgc tgtcacacgc tccgcggtgg agagtttttc tccggtaacc ggatcaacgc 3120961 cttcggttgc tcttttataa tcataatagc cagtgacttc tccagtaaag ttgcaaactc 3121021 catcccatgt tttttcgtac cacggtttgt ttgcttcttc ctcggctttt tcctggagcc 3121081 gtcttgcttc tgcttgctgg gtttttgcat cgatataggt tgttccttga ttttctactt 3121141 caatgacgct tttgtagact tcattgctgt ggaaggcttt tttgtcatag tacatagggg 3121201 atgcgctctt cccattgctg gtggcctgca tgagaacaga atatttggtg agcactgcgt 3121261 tgtccagaga ttctaaattt tgatattcag tggtcaggga ttcatcaagc ttatcgacag 3121321 ctgtgattgt atcacgtctg attttttggg catcgcccat cttatctgca tagtcgtcaa 3121381 gcgtgtacat gtcgagatca ataatatcgc tgatgcctga caaaatagaa tcgatttctt 3121441 ctttatgagc ggagacaatc tctgaggctt tcaggtctcc attgggcagc tcatgatcca 3121501 aaaaagaagt ttccacatat gaatcattca gttcttgatc tttaatatct cctgaaatgc 3121561 cgtttaaaaa cgcaatttga gcagagacaa gcgtcagcca gctgtctacg atttctgcct 3121621 gtccctgaaa aaaatcttta atattgtccg cgccatttcc tttaaaatta tcgcctaaat 3121681 cggcaactcc ctgaaacgct tttttcagcg tattcagctg ctcttcaagc gtctcatatt 3121741 gcttttttct gctcttcgct tcttcgatta aagattttga ttcaaatact ttactcatcg 3121801 cactgccctt tctgttctat tttaccgcta tcgcctcgtc ctgctctttg agtgaatcta 3121861 cgttatcctt tgtatcctcg atatttttct gtaccgcttt tttgtaatct ccgagcatgg 3121921 ttttgatgtt ctcctcacgc tcatggtatt ttttcgtata atcgaggctg ttttttccgt 3121981 tggatcctgc ggcgccgatt gatacgtcag caagcgcatc tttgacagaa tctaatgttt 3122041 tgatgactgt gtcgtacttc agcttaattt ctgacataaa aaaagatcac caccatttta 3122101 gtttactaat tgtatttccg acttcttccg cgaactcttc tcccttttta agaagatctg 3122161 ctgcaccatt tgctatgaac aattccgatg catatttagc tttatcccat tcaagatcaa 3122221 aaattttccc gttaatcgaa gccatatact cgttatattt atcattcaca atcttagatg 3122281 cttccgattt cgcctcttct cttcccttgt cgaaatcatc ggcttttgtt cccgtccaat 3122341 gcttgcccaa ttccggtttc acaatttctt tgatttcagt gattgcctct tcttgcagtg 3122401 tgtctatgtc cttttttgct tttttcagct tttcgatctt gtcttccacg tctgaaattt 3122461 ttccgttgag cgaacttttg atatccgcta gcatactttc ataacccatc tgaatcacct 3122521 cttaatactc aaaaagtcgt atggaggggc tgatgaagat agacttttcc atactttatt 3122581 tccatatatt atattttaaa atagccagaa ggcggcttaa atagggtaaa tggcttaatt 3122641 taggcatata acgctcttga aatgtaggta tttgatcttg tttttgttcg ttatacagct 3122701 aataaaagcg ttttataaaa tgaaatcacc taatgtcata gttataaagg cacttgaaag 3122761 aggcagatgt tgttgatctg cctctttcgg cgctgagctt attgttcatg tttatgttct 3122821 tcatctggtc ggccatgtct gattttgtca tttggcttct attattcccc ccttctgacc 3122881 ctttggatca aaagcttgta ttagctgcag tcccagttgt acagaacgtt tgaaaagtct 3122941 tttttcctta gatcttcagg tgtgatgaaa aaattggcga tgccgacgtc tccccacatt 3123001 gaatcgatat catcgtctga atcaatttgt aacagcatga tggtgtgttc tttatatgcg 3123061 tattcccggg gatcatgctg ggtaaaagaa gcgtatccgc caattttatg gccaaatccg 3123121 ttttcagcca gttcattata aatgtcttct tcatcctcgc cgaactgacc aaagaactcc 3123181 attgtttcca tgcccgtata ctgctcaaat tgaaaatctg taggcagcac ccattccgaa 3123241 gatttcacag gctcgactgc cgcttctgat aaaatcggaa aatcacattc gcctgtgcca 3123301 ataaatgaaa aatcagaaac aagctcgtca tcgttttcta cgatattttc aaaatagatc 3123361 actctgaaat tcttttgttc acatcgatcg tcaaaattca atccatagac gtcatcatga 3123421 acagaaatgt agaactgcag gatacctgaa gaagggtagc cgtcaagctg gggaatgtgc 3123481 gagaaattaa tctgcgccag aagtttcatc ggctgtccat tttcgtcagt cggatatgtt 3123541 tcatgcttgg ggaaataggg atcaccggca attttgctgt catatcgtcc tgttttcccc 3123601 tttctcacat tcagtttcac gtattctttc gctgatttct ccagcaagtc gcggtacggt 3123661 ctcatttttt cgggcagatg attcatcaga ttctctcctt ttccggcatc tccaaggttt 3123721 tattttctgg ttttcttcta atgtttttca aacgaatgtt taaagaagcc ctacttctgc 3123781 ataattttcc aaacaatagt taaatagtag caaatgtatt cagcaccccg caatagatga 3123841 aaaaaagact ggtgcgcaac cagcctttct ttttcatcta ttgaattgca cctgacggaa 3123901 caaccgcctt ccgtccgaca gaataatact ccactcctgc agccaaagcc tcatccaatg 3123961 tgtagcagtt tctgccgtca aatatgagcg gcgtttccat caaatcctga taagccgcta 3124021 acgggaattg tttaatgtca gcccagtcgg ttaaaatcat gacggcgtca gaccctttga 3124081 cagcttcctc gatcgtctct ttatattcaa cagcttgcgg gagaacatgc tttgcatggc 3124141 taactgcaat gggatcgtag gctctgatac gggcgtcgag cgcagcgaga cggtctgcaa 3124201 taacaattga cggcgcttct ctcatatcgt cggtattcgg tttaaatgac aggcctaaaa 3124261 gggcaatcgt ttttcccgtc accccaccga gcctgttcag cgctttatca accagcatcg 3124321 cctgctgatt gttgttgact ttgataacgg atttcagcag ttcaaaatca tgctcgacat 3124381 tgccggcaat ttgcacgagg gcgtttgtgt cctttggaaa acaagagccg ccgtagccta 3124441 tgcccgcttt taaaaactgg ctcccgatcc gcttatcctg tcccatcccg tatgcgactg 3124501 cttcaatatc ggcgccgacc ttttcacata tattcgaaat ttcgtttata aaactgatct 3124561 tagtggccag aaaagcattt gaggcatatt tgatcatctc ggcgcttctg atatccgttt 3124621 ggtaaatcgg gatttgaaac ggacggaaga gctcctccag cgtatttgct gttttctcat 3124681 cggccgtccc gatcacgatc ctgtcaccat gaaaggtatc atagatcgcc gacccctcac 3124741 gcaaaaattc cggattggat gcgaccgaaa tactgacagg ctccgctaga tgttcagtaa 3124801 tcagtccatt aatcaaatcg tttgtcccaa cgggcactgt gcttttcgtt accacgactg 3124861 tatctcgttt gacatgcttt gcgatgcgtt tggccgcatc tgtaatttgc tccagattgg 3124921 cgtgcccgtc gcttttctgc ggtgtgccga ccgctataaa aatgatgtct gcctgtgcca 3124981 agcctttctc atagctcgtt tcaaagttca gccgtccatc agctgtattt tttctcatca 3125041 gctcttcaag acctggttca aatatggggg aaatgccctt tctcatttca tcaatcttgt 3125101 gagcgtcaat atcaatgcag gttacatgat gtccaatctc agaaagagaa acacctgtca 3125161 caagaccgac atagcctgtt ccgatgactg ttatattcat tgtttccctc caacagttaa 3125221 attgctgctt tgcagcttcc gtaatatcgt atgagaacat cctatcatga atgcgaatga 3125281 tctcccgcat agcctgtcgg gtacagcctg tacagatttc tgaaatgtga ttcaaccata 3125341 caatacacta ttatatcgct ctcaaaaaga aagtggtgaa atgagaatcg gctgttaaaa 3125401 aaaaccaaac aattttcttc ttttgaccgg ctgcggaggc tgtctgaaga tggtctgatt 3125461 ccgcaggaga agctctgcat tttccgtcag catataagga agttccgagc cgaattcttt 3125521 ctctagaaca taaagagcct cttgagtgtg aaaatttctc gttttcacat tatgggcatc 3125581 tgaggctacg aaatggatca aattggcttc aaccagccgg agagaaaatg ctttcagctg 3125641 cttgccgaag atccccgcaa gacttcctga agtaatctga gatgctgctc ctttttccac 3125701 aagatgatac agcaaggacg ggttttcgcg aatttccctg ttgcgttcag gatgggcgat 3125761 aaccggaata tatcctttca gctgcaaatc ataaaaaagc tgctccgcat atcggggaac 3125821 gtgatcaaac ggaaactcaa tcaagatgta ttttgtatca ttcagcgaaa gcagctgacg 3125881 tttggcaagg tcttgttcca cctcgccgta gattctgatt tcctgtcccg gaagcacatg 3125941 taaaggaatg tcttctttga ttaaacgttt gtttaactga tctgctgctt ctctgactgc 3126001 ggctggctcg tttttataca caccgttgtt atgatgaggt gtcgcaatga tcgtccggat 3126061 tccctgacga acagctgctc ttgccatttc tatgctgtcg gccgaatcac ctgccccgtc 3126121 atccattgcg ggaagaatgt gacagtgaat atcgatcatg tcctagcccc cttttttcgc 3126181 aaaaataaat aacgggcacg atgcacgtta tttatttttg catgaaattg tccttggttc 3126241 cgtaatatcc gtattcagag tgcttcgaaa gctttttgcc gttcataatc gccccaagga 3126301 gcttgctttt gcacgttgca agcgcctctt tcgcttttgc ggcttgttct ttttctgttt 3126361 tcccgcttga aataaccaga acagaaccgt ctgccacgtt gcctaaaatc tgtgcatctg 3126421 ctacggcaag aataggcggc gtatcaaaaa tgaccatatc atatgccgca cacgcttcgt 3126481 atgcaagctc cttcatccac ttcgaggaga gaagctcggc cgggtttggc gggatcgggc 3126541 cgctcgtcag cacgtcaaga tgtttttcat tcgatgcttg tacagcctgc tccatagagc 3126601 ttttctttaa taaaacagat gttaagccaa ccgtattttc aagaaaaaaa gccgtatgta 3126661 ctgttggttt tcgcaaatca gcatcaatca ggagcacttt ttttccctgt tgggcgaata 3126721 cgacagccag gttggcggcc gttgttgatt ttccttcccc cggacaagcc gatgtaatca 3126781 tgactgattt catttgccgg tccactgaag caaattctat attcgtgcga atcgtccgat 3126841 attgttcaga gttcaaggat ttcggctctg tcattgcaat gacatttctc tgcatccgcg 3126901 agcctctgtt ttttctaagc gccaaaatgt ccactccccg ttttttcaga ttggaaaccc 3126961 tgtaaggtct ttgctgtttt ctgctcattc gcaatggtgg aaactgtccc taaaacaggt 3127021 atgtccagca aggattcgag ctgctcttcc gatttgatcg tattatccaa atgctcaagc 3127081 aggaaggcca gtccgatgct tcccgccaat ccggccgcaa acgcgatggc aatgtttagt 3127141 agcggctttg gcgatacagg ggacgggtgt tctgaaacct cggcttttga cagaatgctg 3127201 acattgtcaa cattcataat ggatgtgatt ttgtcttgaa aaacagatgc tatagtattg 3127261 gcaatatgag ccgctgtttc cgcgttttca tccctgactg atatgttgac cacttgggag 3127321 tcctgttcgc tggatacggt aattttgtca ttcagttctt gggatgtcat cgacaggccc 3127381 atttctttaa tgacttcatc taagatggca gggctcttaa tgatgacatt gtacgtattg 3127441 attaactgaa gattggtttg gacatcgtta aattggactt cttttcgttc atttttcgat 3127501 tggttgacca gaatctgagt tgaattttca tagatgggtg taagtgcgaa gaaactaatg 3127561 agtccgccgg cagcagtggc agccgcggtt acaatcataa tcaaaagtat gcgttttgtt 3127621 aacgttgata atatctcttt taagcttgta gattctccca tgatacctcc aaatctctta 3127681 taacatcctt ttccatctac gattatacaa cgttgaaacc gcatttctcc agcttttcac 3127741 gtgacataat tcgacatttt tttacaatgc gttatgttag tactttttat gtaagcgcta 3127801 tatttactgt gttgacagtg ctgtctcatt ttctcttatt cgggcagtca cgttctctcg 3127861 cataaaaaaa tcccgctaaa ggcgtgcggg atttttatgt tgcatatcca tttttaatat 3127921 gagaaatcaa attttcaagc atttccttcg tcgtcatctc agatgactgc tcaccaattt 3127981 catgtgcatg catcaaaatt ttcagaaatt cttcttgatt caatttcttt tcactcatct 3128041 tttttttcct ttcagcttcc attaagttga aaacacgatt attatatgat gctggttatc 3128101 aatttgcaat ctctaataca tcattcgaca catcctattt tttatgtcct tttttaggaa 3128161 aaacttttta aggccgatgt gttgcgatat aatagagaaa ttggatcttt ttattacgtg 3128221 actcggttag gagcgataat catgcttcag aatatgattt ccaaagacga tgtgctggca 3128281 tctgctgaac agttaaaaga acttcttcct tacaatgagg aaaatgttca gctgatcaaa 3128341 aaagccctta ttttatatcg gcaggattca gtctatcgtt tacaagcagt gagtccgacg 3128401 gaagttacgg cttacgtgca ggatgttgtg cctgtgcggg tcacattgaa cttgtttgtc 3128461 atagtcaaaa gcggctgttc atgtccgtcc ggaagaatct gccgccatat gctggctgtg 3128521 tttttatatg tatatgcaat gttcgagcga gtgggtactt ttacagagta ttggctggag 3128581 agggaaaagc ttgaggaaag caaagagctc gtccgccgcc agtttcagga aaaggtgctg 3128641 cctaatgaag aatcactttc aagctggctt gctttttttg attcagagtt ttctctctgg 3128701 caggcacgta cgccagaagg cagccaaaac atgcagggcc tctattacgg ctacctgtcc 3128761 gcattaaaaa aacatgcgcc gaacaagccg gagctgaaaa gcctgtatca gattcattcc 3128821 gcgattgcgg tttggcttcg catgttcaca ttgattgaag cgggcaagct aaaccccgaa 3128881 caagattttt attccctcaa tccgtacgtt gaacagctga tggatacaat ctacagctct 3128941 attgataaat taaaaacgta cgcgctgtct tttgcgcttg atccgttttt ggataaaaca 3129001 ccggatgtta tccggcattt gctgttgaaa gaagaaattt tccaatatga acgcatccgc 3129061 gtcttcggtg aaatttggag tgcgctgctg tcgcggccaa aatgggtggc acgcgaacag 3129121 gagatattga aaaaagaagc aggacggcgt ttttctcccg aattgcaatt cgggcgcctg 3129181 catttggaat tcctgcaaaa aaatgatgac gttatttttg aggaagcgga tcaattcccg 3129241 ccggaagcgc tcccttatac attccaatgg ctgagtgaaa tgactgccaa gaaggactgg 3129301 aaacggctta aaacatggta ccagcaaatt gaaccaattg cgatgggtta tacgaagctg 3129361 gataagccgt ttaaagagat tcgcgatgtg atcggcgagc tgttccttct gttgaatgcc 3129421 tatgtgcagc aaaccaatga tcaagcgctg tttgagcgct ttgccgcggg ctgtctgccg 3129481 tatacgttca cagaatacag ccatcattta tatgaaaaaa aacgctatgc cgagtggatt 3129541 gaaattcata gccttgtcgg cttttccatc aatgaaatgg ataaaatgat gctcaaggaa 3129601 attgcagcga gcgaccctga ggcgcttata ccggcttacc atagagaagt ggcttttttc 3129661 attgatcaga agaaccgtag ctcgtacaag gaagccgccc ggtatttgaa aaaattgcgc 3129721 accctgtaca aaaaagcgaa aaagcagaag gtgtgggagc ggtatattca gctgctgagc 3129781 tcgcattaca agcgcctgcg tgcgcttcaa gaagaactgc agaaaggaaa gttgattgat 3129841 ggcgagtctt aaagaaattc tcatccacgt cgaacaaatg gaagatgggt catttacgct 3129901 ctcagccttt gatgagaatg agcagcctct tccctacagc catatgaaaa agcatttgtt 3129961 ccaatggcat gaatcctcat tttacggaac ctttctagag gatgtcagct tcatcgggac 3130021 gactgctgtc cttctatctc catggatgac tgtagagctt ctcggcaaaa actcgttcaa 3130081 ctcattcagc tccgtgcagc ttacagaaga aacggagccg ctgatcgagg cggcatcgac 3130141 catctatgaa tttatcgcgg acggcgattt tatgcctgac tatgacgcat ggacaaacgg 3130201 tgtttttcgc tggaaggacc gcgataatat actggaaggc tttactgcgg aatggttttc 3130261 cgctgccgta caggattaca tccagtacga cgatgacctg cgggagaaat gggaacatat 3130321 caaggaaaaa tcgcctgcgg ttacgacatt ccgtggccat tttcttgatg aagaggattt 3130381 tctggaaggc attggctgga ttgacgatca atctccattt actgtcggct tgcgcttaaa 3130441 tgaaccggac tttgacggag acgaatggaa gatcgagatg tttttacgcg ataaaaagag 3130501 cggtgctgta gaattctttg acggactgaa gagcctcaaa aaatcgtggc aggcgtacag 3130561 cgataaaatc gcgcgtgagc aggaccgctt tcacagaacg gttccgtggc tgtcgtttga 3130621 ttccgggaca acgctgatct cggaggaaga agcctggatc ttcctgtcag aagcaagtga 3130681 gacgcttgtc gatatggggg tagaaatcct cctgccgtcc tggtggcaga ttgtcagaga 3130741 cagcaacatg atgctgaaag caaaggtgtc ttcctccccg cgcggcgagt catttgtcgg 3130801 catgaatgca ctgcttgatt tcaactggcg gtttgcgaca aatggaattg aactgactga 3130861 ggctgaattt aatgagcttg tcgccagcaa caggcgcctt gttaatatcc gcgggcaatg 3130921 ggttaaaatc gatccgcagt ttatcaaaca gatgaaacgc ctgatggaaa aagcagaatc 3130981 agagggactc cacatgtctg atattctggc gcgggagcta atggatcagc aggatggcgg 3131041 acttgaggat tcggacctga ttgatacatc tgcttttgcc ggcattcagt ttgatctgtc 3131101 taaacagctc aggtcactga ttcgaaagct cactgccgcg gaaaacctgc cggagcacaa 3131161 agtcagtcct tctttcaaag gaacgctccg cccttatcag aaatacggca tgaactggct 3131221 gctgtttctg cgggaaagcg gttttggcgc ctgtctggct gacgatatgg ggcttgggaa 3131281 aacgattcaa atgatcgcct atttccttca cgtgaaggaa agcggccgac aaaaaacgcc 3131341 tcatttgatt attgcgccga catccgtact tggcaactgg cagcgggagc ttcaaacctt 3131401 tgcccctgat ctgtctgtcg cgctccatta tgggccgcgc cggccaaagg gtgatgattt 3131461 cgccgcgcat tatgaaaacg cagacgtggt gctcacttca tacggtctgt cacatgccga 3131521 tactgaagag ctttcttctg tgacatggaa cacgatctgc cttgatgaag cgcaaaatat 3131581 taaaaacgcg catacgaagc aatcacgcgc aatcaggaag ctgaaggggc ttcaccatat 3131641 cgcgctgagc ggcacgccga tggaaaaccg actgactgag ctgtggtcta tttttgactt 3131701 catgaataaa ggctacctcg gcagtttgac cggcttccat aaacgctatg tgctgccgat 3131761 cgaaaaagac cgggacgaaa agagaatcgg acagcttcag caattaatcc ggccattcct 3131821 tctccgccgg acgaaacggg atgaagaggt cgcgcttaat cttcctgaga agctggaaga 3131881 aaaagaattt atccctctgt cagccgagca ggcatccctt tatgagcagc tcgtcaaaga 3131941 cacttttgac catatgacat ccctgaccgg catgcagcga aaagcgctga tcctcagcat 3132001 gcttggacgg ctcaagcaaa tatgcgatca tcccgcgctt tatttaaagg aagagcaaac 3132061 cgagctgctg gccggcagat cagtcaagct cgaaaaattg ctggaactga tgacagcgat 3132121 ccgcgcccaa aacgaaagct gcctgatttt cacgcaatac attcagatgg ggaacatgat 3132181 gaagcggctg cttgaaaaaa cgttcgggga acctgtgcaa tttttaaatg ggagtctctc 3132241 caagcaagag cgggatacac tcgttgagaa atttcaaagg aaagaatatc cgacactgat 3132301 tctttcactc aaagctggag gcaccggact taatttgacc gccgccaatc acgtcatcca 3132361 ttatgacaga tggtggaacc cggcggttga aaatcaagcg actgaccgtg cataccgcat 3132421 aggccaggag cgctttgtcc acgttcataa aatgattacg acaggaacaa tcgaagaaaa 3132481 aattgatgtc atgcttgaat ccaagcaaac cctgaacgat caaattatcc aaagtgaaaa 3132541 ctggattacc gagctttcca cacaggagct cgaagaattg tttacattaa gcgctacagc 3132601 gcaataatca tgactaaaaa agctggctct aaaagagcca gcttttttcc gttcatagcc 3132661 gtcacgccga atttccaaaa aatccgttac gccggttatc aacagggtgc gcttttgtgg 3132721 cagcacatat acttacaaca aatgtttcat catatgtgcg acaccgtgtt cgtcattggt 3132781 taaggtgaca gcatcggcta tcgatttgat gtcttcccgg gcattgccca tcgctacacc 3132841 ttttcccgca gcctccagca tcgatttgtc atttaaactg tcacctacag cagcagtttc 3132901 ctcgagcgga atattcagct gttttgcaag cctcttcagc gcctgcccct tggaagcttt 3132961 gcgggaagaa agctcaaagt tgtgctcagc cgaactgaca agcgtcaaat cttcggcatg 3133021 ctcatatctt ttccagcctg cctcaagctt ttctttgaag aaagaaaagc cgagaatatt 3133081 gtaaaaatcg attggctcat cggcttcaaa cagctcttga aaggagttaa tgtaagcaaa 3133141 gcccgattgg ctgtattgca cctcggccgc ctgcttaagg acagaaagat ccgcttccgg 3133201 atttgcgctt ctgaatctgt cgagctcaac atcaagaagt tctctgccgt tttgcggcgt 3133261 ataaatcgct gaacctgtga atacctcata ataatagttt tccgactcaa gccatgagag 3133321 aatgtcatac gcccgtttct tatcaatcgt ttcgtgatga taaagcctgc cctcgggatc 3133381 gtgaatgacg gcgccgtttg cactgatgac ccatgttttg atccccagcg gttcaaagat 3133441 tgacatgacg tcaaaatgag cgcgcccagt tgacaccacc acttcaatgc cgtcccgctg 3133501 cgcctgccgc agtgcgtttt cattttccaa gcttacctga tgcttgctgt tgagtaaggt 3133561 tccatctaag tcaatcgcaa ttaatttcac gtttgtcagt cctttccttc atcctgctct 3133621 gtcacgagaa gctcaacgcc gtttcggtca agcaagtcac aaaatgcctg attcggcagc 3133681 ctgtctgtaa tcaagaggtc gatttcattc agctccgcat actgataaaa actggtgctg 3133741 cccagcttag aatggtctgc aagcgcaatt acctgctttg cctgctgtat cattttccgc 3133801 ttcaccatgc catcctcttc atgcgcaatt gtaatgccat gttcggaaat gccgaccaca 3133861 ccaatcagcg ctttatcaac atggtagctt gagagctttt caatcacaga ggacccgtac 3133921 agaaagcggt gctccttttc cagcttgcct cccagcagat aaatttcaat tccctcttta 3133981 tcggacagca catccgcaag attaatcgaa ttggtgatta cggtacaatc aaccgcattc 3134041 aaatgctttg cacatgcctg aacagttgta gaggcgtcta aaatcacccg gtctccatca 3134101 tgaataagcg atgctgcaag cctgccgatc ttattttttt cctcagacac tgttttcagg 3134161 cggccggaat agctttgaat tttctgatgc acagtcggta aaatggcgcc gcctcttgtg 3134221 cggatgatgg cattctgttc ctcaagtttc acaagatctc gtcgcgctgt atcccttgac 3134281 acttgcagga gcgtacagat ctgctccgtt gtaattcggt tatgctgttt taaaaaatcc 3134341 aaaatcgcta ctaatctttc ttcttggtac acgccctcat tccttttctc agcaatcatt 3134401 tataagtaat tataagtttt tatttgattt tattcaacat taataagtga ttttaagtaa 3134461 aaatgcgtcg agagaaccaa tttttcctaa gtaggcaaaa agaaagaacc agtctggtcg 3134521 actggtcaat tttgagggga tgatgcgaag atccggataa tagtgaatgg atagataacg 3134581 ggaggagcag gggtgtcaat cagcagcttt ttcccggggt ttagggtcca taaaacgaac 3134641 agtgtcagcc aacacttctg ttacatacac gttaacgcct tcctcgtttt catagcttct 3134701 tgtctgaatc cgtccgctta cgccgacgag agaacctttt tggcaataca acgccgtgtt 3134761 ttcagctgtt tttctccaaa gtgtgcaatt gacgtaatca gcttcgattt cacctgaagc 3134821 attcttgaag ctgcggttca ccgcgagcgt aacatgtgca actgccgcac cggcggaagt 3134881 gtagcgaaga tcaggatctt ttgtaagacg tccgacaagc atgacctgat tgaacatgcg 3134941 attcctcctc tccttgcggt tgtatgtatt gtaaatgatg caacaagaaa agaaaaacgc 3135001 ttaaaaatgg ctttcagcct ctgtttttat ctttcgtttt catttttcct tcagctaaaa 3135061 acatcttttg cttttttcct ttgaagaaat atgtactttt taaaaaacgg aaaaagattt 3135121 gctttgtcag ccagttttgc gtattcatgc gcacatagga agagccatcc cacgcaaacc 3135181 actgaaagct caattttttt tccggcattg acagcttgat tttatactgc tccatgccat 3135241 cttgtgtttc gtataaaaaa cttattcttc cttttttgtt cagatgaacc tcaaacactt 3135301 ctttacggct taacatatat gttacttcct tttgaatcaa atgactttca gaaggaacgc 3135361 cgtcaatata aatttctttt aaacgaaatt gattcatacc acatctctcc gtaatccata 3135421 gtcagttaca gtataatgaa aaaatagaaa ttattaaatg tttcgctcat acaaaattct 3135481 ttagccccaa cattgcagga ttttttcctc gaaaacgttt atgttataat ggaaggcaag 3135541 aaaactttgg aagtaatcgg ggtgagaaga aatgaaaacc tttaaactgg ttgacctgaa 3135601 tgtggaacga gtggacaagg aagaacaatc aattgaacag tttcccctta ttgacggact 3135661 gattataaat aaagaagacg gtgaaaatca ctggctgatt gaggcgcttg tacagaaaga 3135721 acatctgtct ttttttgaac agcttcaaaa cagccaatct gaagccaaag tatttgtaac 3135781 gatcacgaaa aaaagcaatc gccccgccca gctgacagca gcagtgaaaa atatcgtcaa 3135841 gctggaagaa agcattcagg ttttactcta cggacaaatg gtcacaagaa aacagcaggg 3135901 cactgaaacc attctcgagt cccttgtaaa agagggctat acaggaacaa aactcattga 3135961 ggcatttaag caaaaattat aaatatgagg gggcatgttc cccaaaacag actcagaacc 3136021 gaagagcatc acaatagaca tttagaatag atatgttctg catgaaaaaa gctgccgttt 3136081 tgaacggcag cttttctctt cgtgctttca ctcttgcata tttaatttgt atggccaaaa 3136141 gaatcaacca attccccttt cacaacgagg cgcccttcgg ttttgaccgc cttgtcacat 3136201 gtgattaacg taatctcctt tttgtttgtc tcctcaacta catctgcatc catttccgat 3136261 atgatgtctt tcgatgttac agaatagata taatcctttt taaaatccgt gatgacaatt 3136321 tgggcacctg tttttatgtt ttccagaggt ccgaacagaa gattcttttg cttcaaatga 3136381 tggcccgcca acggataatt tccctcaccc attttttgat cccggcgcat tgttgccgcc 3136441 cctatcaaaa gattttcatt ggttgtgcct tttacgatcg gaagctccag atcgacactt 3136501 ttaattgtta tccgccgcct tgattgtgaa gtaaaaataa gtatatttca cgtgctttcg 3136561 acgttctcca cttgactgga atgctttaat ggcgatcccg gcatctgtag cttcaggctt 3136621 tccttcagag gaatcagaaa tctcaaactc tattttctca gtgttcagca cataaccggc 3136681 tggcgctttc gtttcaacaa aagcgtattg tcccggtgca aggcctgaag ctgtgacttg 3136741 atgatgccgg atatgactgg tttcgaagtc tgtatgaaaa ttcgcgaacg attcagcatg 3136801 gttgatcttc cggttctgat cattacagct gccattatcg gccatgacaa atacaaggct 3136861 tttcatgccg gagcgaatga cattttgcaa aaaccctatc attactctga atttatggcg 3136921 cgtattcaaa acctgataat gatgaaacat acagcaaatc aagccacaag aatggaaatg 3136981 gcgtttctcc agtcgcaaat caagcctcat tttctttata atgtattaaa cacgattatt 3137041 tctctcactc atttggatat tgaaaaggcc cgggaggtaa cagaggaatt taccaactat 3137101 ttaagaatga gttttgactt tcaaaataca tcagccatca gttccttcag acatgagctt 3137161 tcgattatca attcctatct ttctatagaa aagacgcgat tcagtaatcg gcttgaggtt 3137221 cttttcgata tagatgaaga cattgacttt atccttccgc ctttaatgat tcagcccttg 3137281 gtggaaaatg ccgttcttca cggtgtcagc aagaaaagag gcggaggatg gatcaaactg 3137341 acagctaaaa aacaaagcaa aaatgagtat cacatcaaag tagaggataa cggtcccggg 3137401 ataactccgg aaaaacaaat agatctctta tcaacggatt ttgatcgcag cgtcggattg 3137461 aaaaatatca atcagcggct gaaacatttt tgcggaagcg agttgatgat cagcagcact 3137521 ccggatgcag gcacctctgt ctcaatgctc attcatctcg ctgaaacaac aggaagccct 3137581 aaagaactga aggacacaga acgaacctaa acgaaaattg agataaaaaa agacgccgtt 3137641 tctaacggca tcttttttat tccggcgact ttgcttgctg cttcagcagg tctctgattt 3137701 ctttcagcag ctcctcctgc gcatccaccg cttcctccgc agcctcttct tctgcttctt 3137761 ttttgcgcct taacccattc aaagtccgaa tgacgataaa aatggagaac gatataatta 3137821 agaagttcac aatcgtctgt ataaagctgc catatttcac tacagcatcg ccaaacgtaa 3137881 acgacaggcc tgaaaagtca agccctccca gcagcaaacc gaccaaaggc ataatgatat 3137941 catttactag agatgtgacg atctttccga aagcgccgcc tatcacaaca ccaatcgcaa 3138001 ggtctacgat attcccccgc atggcaaagg ctttaaattc attccacata caatcacctg 3138061 cttttctata tttgtaaaga aaaaaagaca aatgtgccgc tggccatctg ccttttttca 3138121 attattctcc gagggcaaaa gtcagttcta cttcgcaaac gacttcgcca tcaactgtgg 3138181 caacgccttt tccgcgcccg attgtgccgc gggcacgaat gatttcaacc tcaaggtgaa 3138241 gctggtcacc aggcttgact tgttttttaa agcggcagtt atcaatgcct gcaaaaaaag 3138301 ccagtctgcc gcggttttct tctttaatca acatcgcaac agctccgact tgagcgagtg 3138361 cttctacgat taatacgccg ggcataaccg ggtactgagg aaaatgtccg ttaaagaact 3138421 cttcattagc ggttacattt ttatagcctt ttgcccgttt gccctcttca acttccgtaa 3138481 tccgatccac aagcaaaaac ggataacggt gaggaataat ttctttaatt tgctgagtat 3138541 caagcattgt cttgacatct ccttcatctg cattagtatg tatagcaatc atcaaagatc 3138601 caatctgtac atttgaaaag tatattatga attaatctct ttttcaaccg cgctaaaatg 3138661 taaccaactg tcaatgagag ccgtcaaaag ttatgatatg ataattatag attttaccaa 3138721 tagcaaagag gtaggaaaat gatttcgaag tttattgaaa aaagaatgct aaacatgtta 3138781 gacgagtggt attccgcaat gagcaaacgc aaaatgaatc acgtttgcac actgaaagag 3138841 aaaattgatc agcaccttcc aaagatcaaa aagaacacaa aactttggat gcgttatcaa 3138901 ttgtttcagg cccgccatca gctgcttttt gaaaaccaga acggactcga ttcattgttc 3138961 gatggcctat atggcctgga agacaaaatg gatgatgaat tgaaatatta tctgtatttt 3139021 ttctctgggt tatatgagat ggtaaaaaca gctccgaaac atgcagtaca tcattttaaa 3139081 aaagctgaac agtacctggc cgccattcac aatacgtttg aagccgctga tttatattat 3139141 caaaccgccg gcgcctatta cttgatgaaa tcaccgccgc tttccgtcca atacgtcaaa 3139201 aaagcattac acatctattt gcaccaattc ggctatatca aaaaggtaat cacctgtaaa 3139261 cttttgctcg ccgtgaatta tattgatcaa gaacgctatg aaaaagctga acagcttttc 3139321 aaagaaatca ttaagaaaac ccagcaacta catgacgaaa acctgctatg ccacgcttat 3139381 tataaccttg gctttttaaa agcgaccgag aaaaaagacc aggaagcgct tctttacttt 3139441 agaaaagtat taaagaatca agaatttgaa atgaattcac cagtctcata tcttcattgt 3139501 gtgtacgagt ctgtcagagc gctttttaaa acagggaaca tcacagaagc taaagccgtc 3139561 cttcaaaaag gaaaagaatt atctgaaaag gtagacattc aaaccattta tttaaaatta 3139621 aaaacgcttg aagccctcta cacatcagcc gaagaccctt atgagcagct gctcgaatat 3139681 gtgcttgaat tagaaaaaat cgaggcgtgg gtggatttag aagtgctgtt agaagatatt 3139741 acggaatact acaaaaaaaa ggacgatttc gaaaaagccg ctttttttat catgcgcggc 3139801 tgattgaaaa acgcccattt tcttattatc tgactgaatt gattaaaccg agcatttgat 3139861 ctcccattgt gatcgttctg ctgttcagct gatatgaacg ctgggacgtg atcaaatctg 3139921 tcatttgttc tgaaatatcg acattggaca tctcaagtga gccctgctgc atgccgatgt 3139981 tttgtctatt agcgccgttc agctcttcaa aagctgccgc attatcaata gagaaaaggt 3140041 tattcccttc ggatttcagc tcttgagggt tattcacttg gacaacgcca agattaaacc 3140101 gctgaaccgc gtttccgtca gatgcggtta aggtgccgtt cttattaatg gtgatattct 3140161 tcattgagct gtcgatgttc actgtattgc cgttctcatc aagtacggga tacccatttc 3140221 cagtgacgag ctgcagctgg ttggcattcg cagcggacgg cgttacatac agcgccccgt 3140281 ccctcgtata ctggcggttt ccatttacat ttacctgaag atactggtat ggagacgtaa 3140341 atgcgatatc cagatcgcga tcggtcttct gaatgcttcc ttgatcagag actaggcgtg 3140401 aactcatcat cgctccgacg ccaaggcgca agccgggcgg cgtttttcgg gcttttgcca 3140461 cttcctcgtt tttttcatca acctgatcga attgctgtct gacaagctca gaaaaattcg 3140521 tatcttttgc cttatagccg gttgtgttgc tgtttgaaag gttgctgctg attgtgtcaa 3140581 tctgctgctg cagctggttt aaggttgttg atgccgttag cattgacctg agcatagttg 3140641 atgtcccccg tttttttctt ccgttttctt aaatttttcc aatttcattt gctgctttat 3140701 ccatactttt atcgtaagcc tgaataacct tctgattcgc ctcaaacgat ctgtacgctt 3140761 cagtcatttc tgtataggcg cttgtcacat ccacgtttga aagctctgag acgccttgtt 3140821 ttaatgaata ggctacctga ttatttccgg ctgcgcttgg cagatcatta ccgtccgccg 3140881 tgctgtacaa atcatttccg tcccgtttga gattgcggac atcttccgcc attctgacat 3140941 caatctggcc ggctgtgcgt ccgttcgttg tcacagtacc gttttcagac acagtgaaat 3141001 tctcattatc aacagtgatt ggctggcgat ccgtcgataa aatagggcgt ccgttgatcg 3141061 tcagctgatt gttctcattt agtgaaaatg tgctgctttt tgaataacgg attccatccg 3141121 ctgtttgaac cggataaaaa agagcagctt tttcattggt ttccgcactc atcggaactt 3141181 gattttcgat caatgcaatg tctgtaggct ggtctgtgga cttcaggctt ccctgtgtaa 3141241 agagaggctt gagctcctgc atatatactc cggtattcac ggaaccgatt tccgtccttg 3141301 atgtcccggc cggagatttt gattctattc tgctgagcag catctcaggg aacgcgcgca 3141361 tagagccttg atcagcttta tatcctgatg tatttgcgtt agcaatatta tttgaaagca 3141421 tttccgttct tcgctgctgg gcaatcattg cggatgttgc tgtatataat ccttttaaca 3141481 aatttcccac ctctaaaaat ggcatttttt ccagttgtca tataggaacg ttcgttctat 3141541 aataaaaact cagtatttta tcctattatc gtcatttaac atcttttcgt gaaggctttt 3141601 tcataaaaaa acctcattct ttttcagaat gaggtttgtg aaatcagctt agtttgcgtt 3141661 taggaagctt gtccatatta tcaagcatga cacctgtgcc gatggctacg caatccatag 3141721 gattttcagc aacgaggacc ggtaccttca gctcttcagc aagcagctgg tcaaggccgt 3141781 ttaagagcgc gcctccgccg gtaataataa cgccgcggtc aataatatca gcagaaagtt 3141841 caggcggtgt tctttcgagc acttgttttg cagcctgaac aataacagcg acagattcac 3141901 gaagggcttc ttcaacttct ttactgttta ctgtaattgt tcttggaaga ccggaaacca 3141961 tgtcccgtcc gcgaatggaa atttcctcgt gacgtgcgtc tgggaaaaca gttgcgactt 3142021 taatcttaat atcctccgca gtacgttcgc cgatcagcag cttgtactcg cgtttgatat 3142081 aatttaagat ttccatgtca aacttgtccc cagccatttt aatagaagag gaggtgacaa 3142141 tatcgcccat tgaaataacc gcgatatccg tcgtcccgcc tccgatgtct acaaccatgt 3142201 taccgcttgg ctggaatatt tccatacccg cgccgatagc ggcaacttta ggttcttctt 3142261 caaggtacac atgtttcccg ccgctttttt ctgcagcttc tttaattgct ttttgctcaa 3142321 cggatgtaat attcgtcggg cagcaaatga gcatgcgcgg ctttgagaac aggcctttta 3142381 cattcagctt gttaataaaa tgtttcagca ttgcttctgt tacttcaaag tcagcaataa 3142441 ctccgtcttt cagcgggcga atcgcaacaa tattcccagg tgtacgtcca accattcgtc 3142501 ttgcctcttc gccaaccgcc agcactttgc cgctgttttt atcaagtgca acaacggaag 3142561 gttcattcag aacaattcct ttacctttaa catggatcag tacatttgca gtaccgaggt 3142621 caataccaat atcccttgca aacatctatt tatatcctcc ttgaaaatct gtttcacagt 3142681 aaatatccac attgtgccct aattatatat attatcataa aatatagaaa aaaagttgga 3142741 agcacaataa gttctttaca aatttttgcg gatgttttat gaacgatttc aagaaggcaa 3142801 tgccaggtga ttacgattgc tgaacaggct ctccttcgag aatttcatct tttttatatt 3142861 tgagctttgt cgcttctcct cctcttaaat gcctgatgga tttatgataa tcgagtattt 3142921 ctttcacttc gtttgccaag tcggggttaa tttcaggcag acgctctgtt aaatccttgt 3142981 gtactgtact tttggaaaca ccaaattcct tcgcaatgac acgaacggtt ttctttgtct 3143041 ccacgatgta cttccctatc ttgattgttc gctctttgat gtaatcgtgc acaccactcg 3143101 acctccctaa aatggatgtg agaagtgtga aatgagatcc gtattctgta aagagtcgtt 3143161 cattatgccg cttcttcgtt gtatggtttt aaaagtaagt ttgtgaaata tgcccacgat 3143221 ccctcacctc aaacactctc tttgttaggt ttgtaacagt gtattagcat tcttttggga 3143281 atatgctaaa aactcaataa ggacaagggg tgaaacgaac tttttcagat tcagcaaact 3143341 atttcgcgtc actaaatttt catctttaca actattgatc gctcctgtaa aatgaaataa 3143401 gcaattagtt acttaggtaa gttttttaga aggagaccga catgtcctac gtcaacagac 3143461 acctcattca tcaaatcaac caaagcgccc gcctgattgc caagaaagcc aatgaacagc 3143521 tagagccatt cggcctttat tcatctcaat ggtcagtttt atattgtttg cgtacgatcg 3143581 gaccaatgac tcaaaaagag atttggtcct atttaaatgt ggaagcgccg actgtgactc 3143641 ggacgatcaa acgcctggag gagaacggct gggttcagag acggcaaggt gaagacaaac 3143701 gggaaaaact tgttgtcctc acaaaagaag ccgagaaaaa atacgaagaa atcaatgtga 3143761 aaatgttgaa attcgaggaa gagctgcttg cagatttccg ggatgaagat aaagaagctt 3143821 tttctcattt attccgcatg tttttacaac aatgaaaata aggaagtgac atacatttga 3143881 aaaaagcgga tgcgatatgg accaaggatt ttattatggt cctgcttgtc aatttatttg 3143941 tgtttgtgtt cttttataca tttttaactg tattgccgat ctatacactg caagagcttg 3144001 gcggcacaga atcacaaggc gggcttttaa tcagcctgtt ccttctgtct gcgatcatta 3144061 cacggccttt ctccggagcc atcgttgagc gtttcgggaa gaaaagaatg gcgattgtat 3144121 caatggcgct cttcgcccta tcatcttttc tgtatatgcc gattcataac ttttccctgc 3144181 tgctcggatt gcggttcttc caagggattt ggttcagcat tttaacgact gttacaggtg 3144241 caattgccgc tgatattatt ccagccaaac ggcgcggtga agggcttgga tactttgcca 3144301 tgtctatgaa cctcgctatg gcgatcgggc ctttccttgg cctgaatttg atgagagtgg 3144361 taagctttcc tgtattcttt acagcctttg cgctgtttat ggttgcgggc ttacttgttt 3144421 cgttcttgat aaaagtgccg caaagtaagg acagcggcac gactgtattc cgttttgcgt 3144481 tctcggatat gtttgaaaag ggcgcactca aaattgcgac ggtcggtttg tttatttctt 3144541 tctgttattc aacagtcaca tcatatctgt ctgtattcgc caaatcagtt gacctttcgg 3144601 atatcagcgg atatttcttt gtttgttttg cggtgacaat gatgattgca cgcccgttca 3144661 cagggaaatt gttcgacaaa gtcggaccgg gcattgtcat ttatccatca atcctgattt 3144721 tctctgtcgg actctgcatg ctgtccttca cacatagcgg cttaatgctt ctgctttcag 3144781 gggcggttat cggtcttggc tacggatcaa tcgttccttg catgcaaaca ttggcgattc 3144841 agaaatctcc ggctcaccgc tccggttttg cgacggcaac gttctttacc ttctttgaca 3144901 gcggaattgc tgtaggatcg tatgtattcg gattgtttgt agcatctgcc ggcttctctg 3144961 ccatttattt aacagcgggg ctgttcgttt taattgctct gcttctctac acgtggagcc 3145021 agaaaaaacc tgcagaggct gaaggaaaag tgtctattgc agaataactt gtcagactgc 3145081 cgggaaatcc cggcagtctt ttttccatta aaacacggcg ccctctcggt tgaacgagag 3145141 aacgccgctt atagcaatta ttcaatgaca ggccgcgcag gtgaatcagg atctaacgaa 3145201 aaatcatagg acgcttcatc acgaaacatc ggatcggcat atatggattg ttgatcgttt 3145261 tttgttgctt ttcgatacga agaaaatgaa tcatattctt tctttttcca catccatatg 3145321 ccgtcttgat ccgcttcctt gtggtacacg ttatgattga ccgtattacc ttcgttttct 3145381 gtaaagtcgt ttccgataaa taatctggaa tcaccggccg tcaatatatt cttttcaatt 3145441 gtgttgtttt tcgtatcgta ctgcagcagc agctgtccgc cgtacagtcc ctttgtgtca 3145501 ttccggtaca taatattgcg ggcaatcaga gaattgctgg tgccgccccg ctttttgtca 3145561 tatcctccga ttgaaatacc ggtgtacgca ttgttgtaca ctttgttgtc tgtgatctga 3145621 atggcatttg catactttcc tttgtgttca gacgttgctt caatcccaat atcgttatcg 3145681 taaactgtgt tgttcttaat ttcgatatcg tgtcctccat cgacataaat cccgcccgct 3145741 gagtattcat ctccataagc aggattgccg taagtcgagt tttgataaac tgtattgttt 3145801 tctacgactc cgtttcgcac gtaatcgttt ttatccgcgg ttccctcata accaattaga 3145861 tcaatcccga tgttattatt gttgcggacc acattgcctg caactgtgaa gccgtcgata 3145921 ttaccgttca gcacaactgc ttcactcgct ccaagcgtca gtttctcaac tgtattgtcc 3145981 tcgattcgga tgtctttcat gctgccagtc ccataaactg cgattccgtg agcatttcct 3146041 tcatccgctg ttgtcttaat cccccggatg tgattatcct taatggcgat atgactgctg 3146101 gaccctgata cataaatccc tatagcagtt gcttcctcag atgaaacaga aagatcttga 3146161 attgttaaac cgctgatggc aatgtcatgt ttatcgtgaa tacgaataag cggtgtttca 3146221 tattcagcgt tcgcaacgga ttcaccgcta atcacgacgt tttcattttc atagtttcgg 3146281 aatgtgatag gctttccgtc cgtaccgctg tgctttacat caagggtctc atgatacgtg 3146341 ccctcccgaa tcatgacagt tgtgccggca gcagccttct cagatgcgtg tgccaatgta 3146401 cgaaacggct tttcttttgt tccttcattt tgatcactgc catttggcga aacatacaga 3146461 taatccccag atccttcctc attcgctttt gtcttatcat aaacgaaagc gaggatgaca 3146521 gacgttaaaa cacccgccaa aagaataaaa taccattttc tcattttcga ttcccatttc 3146581 gttttagaat agatttctaa aaccattata aatgttctat ttatggaaaa ccatttcaaa 3146641 aatatgaaaa tataccgtct aaatagatct tattcagcct ggcggacctg cgcatgttca 3146701 actgtttcaa ttgccaatga tgcaggcggg tgaacacgca tcagaacaat gtagaaaaga 3146761 aaggaaatca gcacacctac aaaccaagaa atatcgtata agctcttcaa tacaggaaca 3146821 tacatgccaa tcagcgaaat cagcgctcct aacattgtgg ctgcaaacgc acggtaattg 3146881 tagcccttcc aatacacata ccgtcctgtt tcggaataca ggtcatctac cgagagctca 3146941 cgtttgcgaa tgataaaata gtcggccatc atcacgcctg ccaccggtcc aagcatgccg 3147001 cctattaagc caagaaacgc atacacgctt gtcgcgctct ccatcagctt ccacggaacc 3147061 gtaaataaag cgagcaacgc tgtgataaag ctgccacgtt tgaaattgat atatttcggc 3147121 agggcattcg ctatatcata agcgggtgat acgatattcg ccgcgacatt tacagagatc 3147181 gtggcgatgc agagtgtgat cacggacaag acgatgacat aagggttatc aaaccgcgcc 3147241 aaaatatcga caacatccca aatcggctct ccgaacgcga cctgcgagcc ggaggtcacc 3147301 gtaatacttg cgaatgcgaa cagcgcaaac gttcccggca aaccgtaaaa ttgtcctttg 3147361 atttgctctt tttgtgtttc agcaaaccgt gtaaaatcag gtatatttaa gatcaatgtc 3147421 gcccagatgc cgatgatgcc agtaactccg gcagcaaacg gccagaatgt ttctgaaaac 3147481 gtatgaaact ttcctggttg agagtatatc gggcccaatc ctccagcaat atcaacggcc 3147541 caccatacca tgccgccaaa taccagatac actaaaggcc ctgcccacac ctcaaaacgt 3147601 ttaatcgact ccatgccgtg atgcaatacg agtaaatgaa tggcccaaaa gaatacaaag 3147661 gaaagcaaac cggacaagtg aatgccgaga atgttccact cgccgccaat ttctccccaa 3147721 cctggccaca tattcaaaag caaaatgttc agtgccgtgc tacccgcaaa ggtctggatg 3147781 ccaagccaca tgatagctgt aaacgccctt agaagcgcgg ggatattcgc gccgtatatc 3147841 ccgtaagaag cccgaatgat cactggaaac ggcagcccgt attttgtccc cgcatggccg 3147901 tttaaggcaa gagcgccaaa taggataagt gatgccgtaa taatgatcgc cagcacctgc 3147961 caaggcgaaa ggccgatcgc aattaatcct cccacggtcg cgtaggtcgg tatgttatgt 3148021 atacatccca tccaaatgga ggcaaagttc attgctttcc acgtccgttt ttcctgtccc 3148081 aaaggcacca gatcttcatt gctcagcctg ttggattgct gctgactctc ttttaatttc 3148141 atagccggct cccctttcca tattgtctat atgtcgtcac acgttatgtt ttttgacatt 3148201 agatgtcact taatataact gaagagtcag acaataacac tggctatgat atacaatttt 3148261 cccgtttgta tttgaacagc ttaaacaaga aaaagagaca gacctcagag cccgtctctt 3148321 tcttaagatg cagttttcat taatgcagca aatctcacag ccattaacag gcttgctccg 3148381 cccgctataa tcataatgat tcccatcata tcaaaatggg ctgccgtgat ttctttacca 3148441 aaaagaatgc caaggatcac cgaagacaaa atcgatccta ggtaacggca ggtttgaaac 3148501 aggcctgaag tcgttcctac catgttggaa ggactcgttt ccagcatcgc tgcctgaagc 3148561 gcgacattgc ccagtccgta gcctataccc aagagcgaca gaatgaggcc tttaccgatg 3148621 gtctggacat tgataaaaaa gatggttaag agcacggctc cagccgtcat caaaagcgct 3148681 cccgcaaaga tcggcttgac gacaccagat cggtcgatcc atttgccggt tagaggtgac 3148741 acaacgatgc tcattccaga cataaacagc ataaacaggc cgctcgtttg aacagaaaga 3148801 tgcatttcat cctgaaagta acttggcaaa ccaaaaaata aacaatagaa gaaaacattc 3148861 aataaaataa actgaacata cacggctgac aggtttcgct gtgttttaaa cagacggaca 3148921 tcaataaacg gcttatccgt tttcagctcg cgccagacaa acgcacagag cagaagcaag 3148981 ccaagcacac cttcaaccgc atgcggcgac gtgctgaacg acagcaaaaa ggatagaagg 3149041 aaaatgattc ccccggcaaa taaaacaatt ccaagaatat cgagctgccg aataatggtt 3149101 ttgattcctg cccctttttt ctgatctttc gggaacatat acaggcccaa taagaagctg 3149161 aggataataa acggcaaatt aacgataaag atcgccggcc agcctcccca tacaatcaaa 3149221 aacccgccgg ctgtcggccc cagcgccgtc atggcggacg caaaaataga gagtacagcc 3149281 aaggctgaag cttggcgctc atgaatatga ttccgaatca agccgacacc tgacggataa 3149341 atcgcactgc tccccaccga ttgaaacagc cgcatgacca ataatgtcat aaacgtcggc 3149401 gcaaacggcg ccccgatggc agaaaccgca acaagaataa gcccgaataa aaacaagcgt 3149461 ttccgcccaa tcaaatcacc gagctttccc gttacgggct gcgctacggc actcgccaag 3149521 taaaacgagg aaatcagcca ggaaaccgtt gtaaacgaga ggtgaaactc atgctggatg 3149581 ctatggagcg caagagagat catagacgag ttcagcggat tcagcattgt tcccgaagcc 3149641 acagctgtta aaaaaacagc tcggcttttt ttcgataaca tcatttcact tgttccagaa 3149701 actcttccgt tgtccgcgat ttaccgattc tcgggaaaat aaagcgcagt gtggcttcat 3149761 gctcttcatc gctaaatgtg gacatggcat ctgtaataaa aatctgctga tagccaagct 3149821 gaaatgcctc ccgtgctgtg ctttccaccc cgatattcgt tgcgatgccg cacaatacaa 3149881 tcgtatcaat gccgcgacgt ctcagctgca agtctaaatc tgtgccaaaa aaagcacccc 3149941 attgccgttt tgtcacagta taatcgccat cctgcacacc gatttccgga acaaattcgg 3150001 cccagtccgc cggcatttcc cctgaacctc cctgcgcagg ctcatccgtt tgcggcttca 3150061 gggcgtccgc tccatcatga aaggctacat ttacaaagct gatgaacccg ttatgtttcc 3150121 gaaattcatc tacgagcttt ttcgcgttcg ggacaacctg gccgctttga tcaatcggca 3150181 caattccctt ttgtaaatca atgataacca atgctgtttt ttgaaaatca atgttgagtg 3150241 tattcatcat acgtctcctc ctgatactgt tagtgtttct cacattgcat attttactct 3150301 tcacactgcc taagttcttt tatgatgctt gtgaaattct cagaaggagc gttttctcat 3150361 gatttttctt ttatgtagta gtaacaggtt gtgcatacga acaaaccggc aagcactgta 3150421 atcataaagg gcgtcatcgc ttcatcacct gcctgctgtc tatcggttcc tgcctgaaaa 3150481 tgcccatgaa tttgcggcgg tccatccaaa gcaggataag acacataacc attaatatcg 3150541 tgctaagatc ctgcacgcca atatcaaaac aatagttaat caagacgatg ttcacaataa 3150601 tgggcataaa aataaccgcc cctaatgcag ccgttcgcgg aatcagtaat aaaacagctg 3150661 ccaggatttc accaaaacct ataaacagtt catagacatg agaataaccg aaaaatgtcc 3150721 acgcgatcgt aaaccccttc ccggcagccg cctcgatttc aggcgtcacc tcgccaaact 3150781 ggccaattac cactttcgcc agaccgtaca cgaaaaaatt aaaggctaaa aacaatcgga 3150841 acgtcgcggg aatcgacttg cgtaccgctt tcctcagcct gccgccttta ttcatcatac 3150901 atccccctca gtgtattatt tgatgtagta cacttaatac agtatagagt attctaatta 3150961 atgtcaattc ccttttcagc tcatatgaat agtttctttt atagatacaa agtcttatat 3151021 cgcaaaaaat gccattctcc ttcctttcca tccctcgata acatttctca aaaaccatgt 3151081 caggaaatct tacatgaaaa tgttttatca ttcttttttc tctataatga agaaatataa 3151141 taattgcttt ttattctgaa agatacggag gaatgagaca tgcaaatggg cgatacagtt 3151201 tttatgttct tttgcgcttt actcgtgtgg ctgatgaccc cgggattagc gttattttat 3151261 ggaggaatgg taaagagcaa aaatgtgctg agcactgcca tgcacagttt ctcttccatt 3151321 gccatcgttt ccatcgtttg ggtgctgttc ggatatacac ttgccttcgc accaggcaat 3151381 tcaatcatcg gcgggctgga gtgggcaggc ctcaaagggg tcggatttga tccgggagat 3151441 tacagcgata ccatccccca ctcgttattt atgatgttcc aaatgacgtt cgccgttctg 3151501 actacagcga ttatttccgg ggctttcgca gagcggatgc gattcggcgc ttttctttta 3151561 ttctcggttt tatgggcctc tttggtttac acacccgtag cgcactgggt atggggcggc 3151621 ggctggatcg gccagcttgg agcgctcgat ttcgctggcg gcaatgttgt tcatatttcc 3151681 tccggggtgg caggacttgt tcttgccatt gtgctcggca aacggaaaga cggtacagcg 3151741 tcttctccgc ataacctcat ttacaccttc ttaggaggag ctttgatttg gttcggctgg 3151801 ttcggcttta acgtcggcag cgcattgacc ttagatggtg tggccatgta cgcgttcatc 3151861 aacacaaaca ccgcggctgc agccgggatc gccggctgga tcttagtaga atggatcatt 3151921 aacaaaaaac cgacaatgct cggagcggta tctggggcaa tcgccgggct tgtcgccatt 3151981 acgccggctg ccggatttgt cacaccgttc gcttccatta ttatcggcat catcggcgga 3152041 gctgtttgtt tctggggagt attctcgctt aaaaagaaat tcggatacga cgacgcgctt 3152101 gacgcctttg gcctgcacgg gatcggcggc acatggggcg gaatcgcaac aggattattc 3152161 gcaacaacct ctgttaactc agcgggcgca gatgggttat tttacggtga tgcaagctta 3152221 atctggaaac aaatcgtcgc catcgccgcc acttatgttt ttgtatttat tgtcactttc 3152281 gttattatta aaattgtaag cctcttcctt ccccttcgcg caactgaaga agaagagtca 3152341 cttgggcttg acttaacgat gcacggggaa aaagcatatc aagattctat gtgaggagtg 3152401 acgctatgag cggtcaaatg ttcaaggtag aaattgtaac gcgtccggca aattttgaaa 3152461 agctgaagca ggaactcgga aaaatcggag tgacctctct gactttctcc aatgtacacg 3152521 gctgcggcct tcaaaaagca catacggagc tctatcgagg ggtaaaaata gaaagcaatg 3152581 tatacgagcg tttaaaaata gaaattgtgg tcagcaaggt tcctgttgat caagtgacag 3152641 agaccgctaa aagggtgctg aaaacgggat caccaggtga cggtaaaata tttgtctatg 3152701 aaatcagcaa tacgatcaac atccgcacag gcgaagaagg acctgaagca ctttaatatc 3152761 ggtacgagat tcggacactc cggatctctt tttttgtgca cagaatcccc ccagaaaccg 3152821 cgattcctct tcgaattctc ttcaagcgcc gttatttcag acaatctcta tttttatttg 3152881 aaacttttca tgagtaagat tagtctacta aatataaaaa tgtaaaaggt gattatttga 3152941 actacgaaat ttttaaagca atccatggac tatctcatca caattcagtt ctcgattcca 3153001 ttatggtctt catcacggaa tatgccattg tcgcctatgc ccttatccta ttggcaatct 3153061 ggctgtttgg gaacacacaa agcagaaaac atgtgctata cgcaggcatc acaggaattg 3153121 caggccttgt gatcaactat ttgattacgc ttgtttattt cgaaccgcgc ccgttcgttg 3153181 cgcatacagt gcatacactg attccgcatg ctgcggatgc ttcatttcca agtgaccata 3153241 cgacaggtgc attagcgatt tctattgcga tgcttttcag aaaccgcaaa atcggctggc 3153301 cgcttgtcat ttttgggctt ttgacaggct tttcgagaat ttgggtggga catcactatc 3153361 cggtagatgt attgggcagc ctcgttgtcg ccatcattat cgggttcctt ttctttagat 3153421 tttcagatct gcttcgcccg ttcgtcgatt tggtcgtgag gatctacgaa gccattatca 3153481 ataaactgac gaaaaaacca accgatcaaa atttctaaga aagacaaaag ccggcgtctg 3153541 aaatcaagac agccggcttt aatatttctc atacatctct tgttttcttc gcttcgccaa 3153601 cacatataaa ccataaaaca acccaattcc aacagcatcg atgagcacat cccggataca 3153661 accattcctg ctgaagaaga gctgaagaac ttctgtgaaa aaagcaaacg caaatgagcc 3153721 ggctgcagct gatcttatgc tgccccgctg tttccacagc aaatatgtca gcacaaagaa 3153781 ggaaaacgcg tgtccgattt tttgaataaa cgcttcaggt acagtaagct cagtaaaatc 3153841 cataactaaa aattgagaca gatcagggtg cggctgaaaa tgaaaagcca ccgtttgcga 3153901 tacgaccatg ccgctgaagc tttccgtaca gacagaaagc aggataaaaa agatccagcc 3153961 tgcgagcaat aggcggttca tgacataacc tcctttataa cgtacgtgcc tacatgtaac 3154021 tacatagacg gtaaaacaaa gcaaaaagta acagaaaaaa acgcccatca caaggataga 3154081 cgttttcttc attaagactg ttcagtgtct tctgttgtgc tgctttcttt agaaccagat 3154141 ttgtcagttg aatcatcctt tttctcaccg gatttttctt ctgttccttt ttcagttgat 3154201 ccgtcctttt tctcggaaga ttgctgaatg gattcttctg tttcttgggt ggcagctttt 3154261 tcaatagaag aaactggttt gtccataaag tttaacggat tcattgcaac cccatcttta 3154321 cggatttcaa agtgcacgtg gtttccgctg tcttcactgt aaaggttctt gccagatttt 3154381 ccgatcactt gattttgttt tactttgtca ccttgctcta cgcttacttc ggaaagagat 3154441 tgatacacag tcgataaacc gtcggcatgt tctacttcca caacatatcc cagcactgga 3154501 tctttttcag ctttaacaac cgtaccgctc agagaagcag agacatcgaa atcttttccg 3154561 tctttctcag ctaagtcaat tcctttgctt aggctgtacg tgttattata ggtaacgagt 3154621 gctgcttctt tctcttcttt tgcggcatcg gtttcataga actttttcac aacagaaacg 3154681 ttttcagaat caacaaccgg cattgcgaca ttttccattg actttcctac ttcaactgca 3154741 tcgtcgttgt tgtcatatgc ggagtttccg ccgttatcag ccaactgatc ctttacctca 3154801 tcatttgata ctgattgata ccaaaggaca gctgttaaaa tgacggccgc actgactaag 3154861 taaattgcag ggaacaccca gcgtttacga aaaaactgct gaagtttttt gacttgagaa 3154921 gttttctttt cttcctctct cattgtttca tcacctcagc aacattctga acacttttct 3154981 gaaaatatat acaacctatc caaaaaaact tttttagatg tagtttgcac agactgaacg 3155041 aaaatatgta tttttttgag aggagtgcca aaaacgtatg aacatgacat tgcgtcttgc 3155101 tgaacataga gacttggagg ctgttgtggc gatttataat tcaacgattg cttctcgaat 3155161 ggtaacagcc gataccgaac cggtaactcc tgaagaccgg atggaatggt tttcgggaca 3155221 tacagagtca cgtccgctct atgtggccga ggatgaaaac ggaaacgtcg ctgcctggat 3155281 cagctttgaa acattttatg gaaggccagc ctataataaa acagcggaag tcagcatata 3155341 cattgacgaa gcatgccgcg gcaaaggtgt tggatcatat ttgcttcaag aagcgctccg 3155401 cattgccccg aatcttggca tccgctcact tatggccttc attttcgggc ataataaacc 3155461 aagcctgaag ctgtttgaaa agcacgggtt tgcagaatgg ggactattcc ccggcatcgc 3155521 cgaaatggac gggaaaagat acgatttaaa aattttaggg agagagcttt catgattagt 3155581 ctggataaag atgaaaacga aattgaacat cataatgaag aaaatagcct tgttgaacag 3155641 gagactgcac ctgttggaca ggagagccgc cagctgagcg cctccgctgt caagtcgcta 3155701 tccgacattg ccaagtgggg caaaatttct ggcatcttgt taatcattat gggatcgctt 3155761 gtcactctgt ctgttttgat gacagtgatt ggcgccatcc cgggcgtact gctcattatt 3155821 tcaggcgtat ttttgatgcg ctcagcaaaa gcagccgcgg aagccgaagg aaatctaacc 3155881 ggcagcgctg gcgaaagcat gcttgaaaat tacgggacat ttataaaaat gcagctgttt 3155941 tatgcagcat ccagtatcgt tactgtcctg atcgggatca ttgtagccat tttcgtgctg 3156001 gtggtaatcg gcattgctgc ttttgagaac acgccttcgt atgatgatcc ggattcttat 3156061 tattatgagg atgatccggt gtttgaataa tgatgagaca ggacagggca tgagttccat 3156121 ataaacggaa ccatgcctat tttatttgac tattcaaagc aggccggcgt aaacaccaaa 3156181 tcctgaagca agcatacaat agacatctct agtagaggaa atcaacaaag caacgctgtt 3156241 acccagaaat gaatatcaaa aaaacggatg aagtcggaat caatccgaaa ccgcactttt 3156301 tatttcgggt gtctgcatgc aaaaaaacac acccggatcg tctggaaaat ctcaacaatc 3156361 cgggtgcaga tcttctttaa tacatttttt tgcgtctgtc ttcctcagtc aaaaattcaa 3156421 caaaactccg catcgcaaaa ggctcttcct ttatttgtcg tgcgtaggag cttttccgct 3156481 cttctgaaag gatttcgctc tttttgatcc tgttcagcat atagatgtga accgtttttt 3156541 ggatttgttt atgctgatag cctgcctctt taaaaaatgc gagcccgagc gccgccaaaa 3156601 gggcgaatat gcctgcgctg atcagggact ccctgtcagc tgaagcatga aatagaaaag 3156661 cagctaaatt aaagagagag aatgcagcaa gcggaatagc aagaaaacgg taaatgacgg 3156721 tttttttcat gaaaggctgt acggcctttt gaattttttg catttctgtt ttgatgaacc 3156781 ccggcatttg ttcgactctg taaaagttca tataatcctc cccctttatt tgatgtttca 3156841 agcttcacga acgttatcat atgtgtttat tttaacgcag gtgcaagctg gttttaaaga 3156901 aatctgcccg tatttttcac gaagaatctg gatcgccgct ctttattctt ttaaaatgtg 3156961 agtgttataa tttgtaatgg gaatcagatc actgttattc atggaatact aatggcaatc 3157021 ttcttgataa atatgaatga gcggggttac aaagtgagta tttcttccat ccttttatca 3157081 ctttttttca ttttaaatat tcttttggcc atcattgtca tcttcaaaga acggcgcgat 3157141 gccagtgcat cttgggcgtg gctgcttgtt cttttcttta ttcccgtttt aggctttatt 3157201 ttatacttat tattcggcca taatctcaga cgcaagcatt tgtttcaatg ggaagaccgg 3157261 aaaaagattg gaattgaaag gctgctgaag catcagcttg aagatttaga aaccaagcaa 3157321 tttcagttta acaaccgggc aacctttgat aacaaagatt taatttatat gctgattatg 3157381 aataaccatg ctgtgtttac agaggataat tcagttgacg tcattacaga tggacgggat 3157441 aaatttcagc ggctgctgag tgacatttca aaggctaagg atcatatcca tttacagtat 3157501 tatatttata aaggcgatga attaggcaaa aaattgcggg acgctctcat ccaaaaggcg 3157561 aaagaaggtg ttcaggtcag agtgctttat gatgaactcg ggtccagaac gctgagaaaa 3157621 aagtttttta aagagcttcg cgaggctggc gggcatgtgg aggtcttttt cccgtcaaag 3157681 ctcaggccga ttaacctgcg gctgaattac cggaaccatc gaaagcttgt gatcatagac 3157741 ggtatgaccg gttatgtcgg aggctttaac gtcggagatg agtatctagg gcttaatccg 3157801 aaattcggtt attggcggga tacgcatatc cggctgcaag gaacggccgt gcacgccatc 3157861 caaacacgat tcatccttga ctggaaccaa gcttctcatc accatacgct gacatatatt 3157921 ccaaatcact ttcctgatta cggcccaaaa ggcaacgtcg ggatgcagat tgtcacaagc 3157981 ggccctgatt cggaatggga acaaattaaa aatggctaca tcaaaatgat ttcgaacgcc 3158041 aagcgttcca ttttgataca aacaccttat tttatcccag atgcaagcct gctggatgct 3158101 ttaaggatcg cttgcctttc gggcattgac gttaacatta tgattccgaa caagcccgat 3158161 cacgcctttg tatactgggc gacactttcg tatatcggcg atctgctgaa agccggagcc 3158221 actgtctata tttacgataa cggctttatt cacgcgaaaa ccatcgtggt ggatgacgaa 3158281 atcgcttcag tcggcacagc gaacattgat gtccgaagct tcaggctgaa ttttgaggtt 3158341 aatgcattta tttacgatat caccattgct aaaaaactgg tttcaacttt taaagaagat 3158401 ttgctagtat ccagaaaatt cacctatgag gagtatctgc agcgcccgtt gtggattcga 3158461 ataaaagaat ccgtctcgcg gctgttgtcg ccgatcttat aagatgcgta aacccccggc 3158521 ctttacggcc gggggttttc ctgatggtca cagtaaatga tgattgcctc ccgcaaaaaa 3158581 gcggcaagac cttctccata ttgattgatt gaatcggtaa atcgctcgtc agtgatatac 3158641 acttccccga gtcctctgaa aatgtcgagt gtgcaatcgt aatgatattg gcaaatatga 3158701 tcgcgaaatg cccccacagc ggcctgaatc tctgcatcat cgggcccatg cttcattcgc 3158761 gccgcaattc gtctgtaaat cgaatcaaat tcagccatga tcgtgcgcca atcatctgcc 3158821 gagtatgcag atgtcctttt ctctgtttct tctgcgattt cctttccata cagctttctg 3158881 acttcatcag cgtatgtctg ctggtgctct tcaatgtctt tcatgcttaa tccggcaaat 3158941 aaatccctct tattcatcgt ttcccctcca tcaacggaca aaagcgtcct gtcaattgtt 3159001 tgaatcatct catccattct ttgttttttc ttcatcaata tctccttttg cgactgaagt 3159061 gccgctttcc ggtcaaaatt cggatgatcc agcatctctt taatctcatc cagacgaaac 3159121 ccgatttcct tgaaaaataa aatctgttgc agtctttcca ggtctgcgtc actgtacaaa 3159181 cgatacccag catcagtaag cgctgaagga ttcagaagct caatattgtc atagtgatga 3159241 agcgtccgaa tgctaacgcc tgatatctcc gccacttgtt taacttgata tttcatacat 3159301 aacacctcct cttttttatc gtaaacaatc acgcaacgtt agggtcaatc cccaaaatgt 3159361 tattttctat atacaaaact tctcacaaat agtgtataaa agaaaagtga gtattttttt 3159421 gtaaagggga gccagtatac atgaatcctg aaacaatgaa caaaaccctc atcagcattt 3159481 cgaaatgggg aaaagctaca ggcattttat ttattattat gggcgcaatt accgcgcttt 3159541 caggcgcgtt cttttttcta atcggtgccg tgccaggcgt actgcaaatt atttccggta 3159601 tctttttgat gaggtcagct agggaagcag gccaaatggc tgaacacaat agcggacagt 3159661 ctgaagactt aatgctggag aattacgcga aattcgtaaa gatgcaaggg atttatttga 3159721 tcgtaagcat tgctgtatcc attcttgcga ttatcgcctt cttcatcttt ttaatgcttg 3159781 ggattgctga cggccttttc agcgatacgt acagcactta ttaatgagaa aaacccggag 3159841 ctggctccgg gttttttatt attccgcttc gcttaccact gtgaagcgtt catttttgtg 3159901 ttcgggatgt tcaagctcgt ccaacacggc aatggcataa tctgcatagc tgatatagct 3159961 gtctcctttt gcatttacga tgacattgtc ttttcctttt tggtaagagc cagtccgttt 3160021 tcctgctgga tcaaaaaatg ccgcaggact gaggaacgtc caggaaatgg agtctgtctg 3160081 ctgcaaatct ttcaggttct cgccttgatt tgatgcagtt ggcaaatatt ctttcggaaa 3160141 ttccggcgta tccattaaac gggttgtttt ggcttcatca acaaacaggc ttcccgctcc 3160201 gccaacaaca agcaatcttg tgtgcttcgc gtcctttaaa atgctgatga gtgctcttcc 3160261 tgcttcaaca tgaagatgtt cttggccggg tgctgctcca aaagcgttta cgaccgcgtc 3160321 gaaaggcttg atgtcttccg cagtcagttc aaacacatct ttttccaaaa tcgctacgtc 3160381 ttgctcctgc acttttgaag cgtttctgac gatggctgtc acttcatggc ctcttttttt 3160441 cgcttctttc aaaatctcgt ttcccgcttt cccgcttgcg cctataatac caattttcat 3160501 ttttcatttc ctccttattt gtaacaattt tagttacatg ttagcggtga gaagtcatcc 3160561 cttttgatta aaagagatga ttcataacat cttttaatga cttgcttgcc agttcatttt 3160621 ccatcgctct ttgcacactt tcaaacgttt catccagagc gttctgaatt tttttcccta 3160681 ccggacattt cggattcggg ttttcatgaa ccgcaaagag ttcttcttgc ttttggacag 3160741 cccggtacac ttctaaaaga gaaatatcag caggatcttt tttgaggctt gcacccggca 3160801 ccccggcgcg tgatgtgaga atatcagctt ttttcagcag gctgatcatt cttcgcacaa 3160861 ctaccggatt cgtgttgaca ctgtctgcaa tgatttctga agatgttttt tcatccatcg 3160921 agatgaggga taaaatatga atggcaacag caagacggct gttaatcatg ttttttcacc 3160981 accgttgtaa ctataatagt tacatttgat tcgtttgtca acatctaata tacactaaat 3161041 acatgggttt tgtgcaccgt ttttagtcaa tagaacggcc ggatgcactc cggccgcgtc 3161101 ttatcaaaat aagaaatatc tttgtccaag tgggacataa tcgacaggct ggcaagacaa 3161161 ttcctccccg tcagcaaaga cctgataggt ttttggatca atctcaatct tcggcaaagc 3161221 cgaattcagc ttcatatcca gcttgctcag ctttctgata tttttgactg gagaaatcct 3161281 tttttccagc cctaagcttt ccgccacacc acgctctatg cttgcctgag acataaatgt 3161341 aatcgaggtt gagcggttgg cttttccgta agacgcatac atttggcgca tgaaaaccgg 3161401 ttcaggagtc gggatggacg cgttcggatc tcccatttgc gcacgtgcaa tcatgccgcc 3161461 ctttaagacc agttccggtt tcacgccgaa aaataccggg tcccacagaa cgagatcagc 3161521 aagcttccct ttttccaccg agccgacctc atggctgagc ccgtgcgtaa ttgccggatt 3161581 aatcgtgtat ttggcaatgt accgttttgc gcgcacattg tcattcccgt tttcaccggc 3161641 aagagcgccg cgctgttttt tcattttatc ggctacctgc catgttcgga tgatcacttc 3161701 accgacccgc cccatcgctt gggaatccga tgatgtcatg ctgatcgcac ctatatcatg 3161761 gagaatatcc tccgcggcaa tcgtcgccgc cctgattctg gaatggctga atgccacatc 3161821 ttcaggcact ttcgcatcta aatggtggca gaccatcatc atgtcaagat gctcatccat 3161881 cgtattaacg gtataaggaa tggttggcgt tgtagatgac ggcagaatgt tcgcgtaaga 3161941 ggcgagcttc ataatatccg gagcgtgacc gccgcctgcc ccttcaatgt gataagtatg 3162001 aataacccgg tccccgatcg cgtcgagcgt gttttccaaa aagcccgctt cgttaatcgt 3162061 atcggtatgg atggcaactt gaatatcagc ctcgtccacg acttccatac acgttttaat 3162121 ggcgcttggc gtcgttcccc agtcttcatg gagcttaaga ccgatggcgc ctgcttccac 3162181 ctgctcgatc agcggcgctt tatcggatgc attccctttt cctaagaagc cgacattgat 3162241 cggaaactcc tcggccgctt ccagcatcct cgccatatac cacgccccgg acgtacatgt 3162301 tgtcgctttg cttcctgtag cgggtcctgt tccgcctccc aaaagggtcg tcacacctga 3162361 agaaagcgca acttccatct gctgaggaca aataaaatga atgtgcgtgt ccactccccc 3162421 ggctgttaaa attttgcctt caccggaaat cacctctgtc cccgctccga tgaccatgtg 3162481 cggatcgact ccatccatga tatcaggatt tccgcttttt ccgacaccga caatccggcc 3162541 gtctttcaca ccgacatccg ctttgacaat gcctgtgtaa tccaatagca cgacgttggt 3162601 gataaccaaa tccaaagcgc cgtccttccc tgtgattctg ccgttttggc ccatgccgtc 3162661 tcggatagtt tttccgccgc caaagatcat ttcttcaccg tatactgtga aatccttttc 3162721 gacttcgatc cataaatccg tgtcgcccaa tctgatttta tcgcccgttg tcgggccaaa 3162781 cagttccgca tattcctccc gtgacatttt catcggatta caccctccat ccagccggct 3162841 tgttttaagt tggccaacgt tttttctttg ccgcgttcat cgataaacgt gtcggccatt 3162901 ccgttcagcc ctctaattgt cttgcgtcct ctgatttcca ctagtgagac cgttttctgc 3162961 tctcccggct caaaacggac cgacgtgcct gatggaacat caagacgcat gccgatcgcc 3163021 agctcacggt caaataataa agccccgttg gcctccgcaa aatgaaaatg cgaaccgact 3163081 tgaatggagc gtgatccggt gttttttacc gttacctccc gtatctcacg gccttcatta 3163141 atcgtaatgg ttccctcagc aatttgaaat gctcccggct tcatgacttc acctccgcag 3163201 aaattggctg atgtaccgta acaagcttta caccatccgg aaatgtggcc tccacctgaa 3163261 tgctgtccag catctcaggc acaccctcca tcacatcttt ttccgttaat acatggcggc 3163321 cggcttccat cagctctgct actcccttcc catcacgtgc gccttccata ataaagcagg 3163381 tgatataagc agcagcctca ggatagttca gcagaacgcc ccgcgccttt cgctgtttgg 3163441 ctaattcccc cgctgcaaaa atgagcaatt tctcttgttc aactggtgtc agtttcatct 3163501 gtagtcctcc ttcttttgtc atataaagca gatgcggcta ctacgaattt gcggaacagt 3163561 caggcgggac atcacctccc tttcttcgag aatgggggtc atacggtaag atgcctttca 3163621 aagcggcatg ccgtttcttc atcagccttg ccatggtcaa caaccgttcc cctgtcgatc 3163681 acggaaagat cagattaacg cgttttccag actgcgctcg actaagataa caaatgtctt 3163741 tttttctgga aatttctata ataacttgtc tgactagttc gacaattaaa atctgaattc 3163801 cttccaattg tttattaagt aaaatatttt tcagatttac catcagcgct ctggtgattg 3163861 caagctgctg ctgttgaccg ccttttcgtt ttgaacaaac gtttgattaa aacaaatagc 3163921 cccctctgtt tagccggagt cggcctaata cagcgacaat ctgccccggg cgaagctaag 3163981 gctgtgcaaa accatcgatt gatcataacc agacgttaca ttcctgatgg cagcccgttg 3164041 ttttgctccg caaccggaag catggcatgg aggccagtct gaggcgccga cctccacgat 3164101 accgagaacc cgactattgc cattaactcc gcatcatgga cggtcacttc gctgatcgcc 3164161 accgttcctc ttaatgagtg aagaattccg gccttcactg aatccccgct tgtgtcgata 3164221 tcaactgttt tctcgcactc ccgtggcttc cgacactttc ttcggtgcag tacattccgt 3164281 catcaaaacc cctttgtttg atttcttcaa atgatgttat aaaagtttac aacttatgtc 3164341 atcattatat agaagaggcc tattaattca aagaatattt aaaaaattta gttaccttga 3164401 ccaaatcagc ttcttttttt gttatattta ttcacatcag aaaaagcgaa aaaaaaagac 3164461 aagaaacatt tcgtttcctg cctcttccgt acgattaatc tttatctgaa aatttatcct 3164521 tggctttccc gatatccttt tggatttcgc cttttgcctt atcttttttg ccttcagcct 3164581 gcatgtccgt tctgtcagcc atatctccga ctttatcctt cacttctcct ttggctttat 3164641 tgaagccgcc cttcattttg tcttttacac tatcgttacc catgttaatt ctcccctctc 3164701 aattatgtgt gtacttgtta acttcccgat ctgagaggca ataaacattc taatgttatt 3164761 tatcgatttc gtagcgctct ccgtaacgga gcaccttgta tatcgccagc ccgtctgatg 3164821 actttttctc cgaatatcgg accggcagca gggcaaaaaa cacataatac gtagaaaaat 3164881 agacaaactg atagaaaaac acattcggct ttaatacact gtgtataatc agcagattga 3164941 ttgcaaaaat cgtgatgagg ttaaacaagc agccccctgc atacacgagt gcatttgaga 3165001 atcgattgtc aattttcaac tccccgtacc ggcaaaaaga atcgataaaa taaatcgttc 3165061 tgaaccgtat gggtccaatt ttaagcagcg tttttcccat gcctatatcc aacgatccct 3165121 ttccgccaaa aataaaagcc ataaagctgt gccctgaaac atgtataatc tgtacaagcg 3165181 gcagaacaat gaggaaagac cacagaaact tcaccatatc attaaaacca aacattgaat 3165241 tccccctcac atgcatatct gcatcccaaa acggcttttg ttcaaaaaac agtgctgtag 3165301 cgatttttcc tgttctcccc ggaaataaac gttccgatgc tccccttttt ttgcataaaa 3165361 aaaaaccatc tgccagcaga tggttttgtc tcatacttca tataaacaat cgttcctttg 3165421 aatcatctct ctcatgctga ccgctttttc ataaaaatac accgcttctt tatattgttc 3165481 gcgatgactg aaataagagg cagcatctaa agcaaattct tcaatatata catacaggcc 3165541 cttttcttcc atataatcaa atacttcttg aatcatattc aaattgacag attccacata 3165601 taatgcctgc agaaatttat attttgccag actgaagaag tcgtttcgtt tttgggcaat 3165661 ggcaatccct ttttcatagt accgtatcgc ggcttcgcta tcttgttttt tgaaaagaac 3165721 gcgagtcagg ctgaagagcg cttttggaag ctgttccagc tgataatcct cgaagacagg 3165781 aagcgctttt tcaaagtatt cggcggcctg atccagctcc cccttgtcat catagcaatt 3165841 accaatatta taaagggctg atccgatcaa acggggctgt ccttccaata aagcaaggcg 3165901 atacgcgtca tctaaatgtt caagcgcttt ttcataattt ctgtagtcaa tgtagtttcc 3165961 tgatatgacg aaatggcatt gaattcttct gactctgtaa aaatcgtgag ccttatacgt 3166021 ctccagcgcc tgtacggcat ggttcatgga aaagtgcgtc tgcttcataa tataaaagac 3166081 ttccgccact ttaaaatgaa attccgctct ttcaatttca tcttctacaa acgcaagcat 3166141 cttctcagct ttccgataaa aggatatagc cgagatgtaa ttgttctgtt caaattcgta 3166201 cattcctcta aacaagtgaa aataatactc agataatccg gagatgctgt cctgattgct 3166261 ttccagcgtt ttgatcaatt cacgatattg aagctgagat tcctcgtgca ggtcaggctt 3166321 tacataatcc agcataattt ggtgccggta gctgatcagc tgataataca ggagaagcag 3166381 ctgatcctct tccatctgtt cgatatctag atcaatttct tctttcagtt ttacggcatc 3166441 agccacttga aatgctaaaa tgtgcttata ccacttattg attttcactc ctacttgaga 3166501 tgacgggatc tcgtacgcgg ccatgcccct ccaacccttt ctattttcta attggttata 3166561 ttttatcata atgtatggct ttggaattaa attttcttac aatgattcct tctttatgcc 3166621 tatccttata tatttcggtt tttctacgta ttttttgcac tcggattcta ataaaaaagc 3166681 ttaccggaca gtgccgataa gcttttgact tcaaattaac cgccaatata agacatttcc 3166741 actttctttt tgccagatgc ttttgatagc gtacgatcga ctgaatactg atcgatccga 3166801 tttttccata ctgtcccgat catttctgat agttcgtcat cacttaattc ctggcgaacc 3166861 ggagctctga ggtcaaatcc gcttgaagcg aataagcagg taaacagctc tcctctcgca 3166921 gaaagacggg ctctgttgca agatccgcag aatgcatcag atacagatga tatgacgcca 3166981 atttctccgg agccgtccaa gtagcggaat ctggaagcca cttcgcctat ataattaggc 3167041 gctatcggct caaccggcat gtgtttattg atcaaatcta tgatttccgc ctttgtcatg 3167101 acgtctttct tttcccattg gttggtgttg cctacgtcca taaattcaat gaatctcagg 3167161 atatgccctt tttctttaaa ataacgggcc ataggcagta tatctttttc attgacgccc 3167221 ttttgaacga ccatattgat tttaacaccg agccccgctt gcttcgccgc ttcaatgcct 3167281 tccagcacct tgctgacaga aacaccgcgc ccgtttatct tcttaaaacg ctcgtcttct 3167341 aaagaatcaa ggctgatcgt aacccttttc agcccagcct ccttgagcct cttagcataa 3167401 acaggcagca gtgatccgtt tgtcgtcatc gcgatgtcac gaatacccgg tatgcgggcc 3167461 agttttttga ttaattccgg catatccttt ctcatgaggg gctctccgcc ggtcaagcgg 3167521 attttttcaa cgccaaatct tgtgacaaac aatgtcgcaa gccgttccag ctcctcaaat 3167581 gaaagcagct cctctttctt taaaaaagga taatccgggc cgaataattc ggcgggcata 3167641 cagtacgtgc atcggaagtt gcagcggtct gtaacagaaa tgcgaaggtc tctcagcggt 3167701 ctgtttcttt tatccaacat ctgacgcgac tctgtaatca tagctacagc cccttcctac 3167761 tccctgattc tctcagggtg tgtatataca ttaaatgatc cgtttctgac aaatccaatc 3167821 gctgtgatat tcaattcttc agccatttga atcgcaagct ccgtcggggc cgatttggaa 3167881 atgacaatcg acacgccgat tttggccgct tttaacagga cctctgatga gattctgccg 3167941 ctgaacacaa tcagtttgtc gcgtacggac atcccgttta gaaggcagtg tccgtatagt 3168001 ttatcaagtg cgttgtgccg accgatatct gtgcgcatca acagaagctt ctctgtgtcg 3168061 caaagcgccg cattatggac gcctcccgta tcctgaaacg tcccgctccc ttgctgcatg 3168121 tctttcataa gcgccagaca tgcctcaggc gatatcttga tttggctgac agccgtcttg 3168181 gctgttttga catcctgctg aaaataaaaa tgacggccct ttccgcagca tgagccgatc 3168241 acccgtttcg tataatcctt ttgatccaat gtctcagggt gaacgaggtc gacatataca 3168301 aaaccgagac tttcatctat tgtaaacctt ttaatttctt tttgaaatcg tataacaccc 3168361 tctgatgcga gaaatccgat gacaagctct tcgatatgct caggcgtaca aacgagcgtc 3168421 acaaattcac tgccattcag tatcactgtc aaagggaatt ccgtcaccat ccggtcttct 3168481 actttgctta tttccccttg ttcatagcgc catacatccc tgaccgcagt tactttatcg 3168541 ttcaatgtct cttcccctcc gcaatgttcc tgcctttata ttttttcaca ctcctcggat 3168601 tttgtcgaat tctgagacac aaaaagagcc ctctatataa agggctttta caggatgtga 3168661 tgacggcggt gtttaggcag gacgcctaag catttagccg ccgttccttt tataacacgt 3168721 gagcaccaat gtgcattgac aacgaacgcg gggtttgtcg acacgctgag acacctctgt 3168781 ataaaggact ctatgtttga ttatgctgat tctttttcag aaccgtaaac agcacaatag 3168841 ctgcgatcaa ggtgagaatg ctgacaaaaa agaaggctgc cagttttaga agaacaccaa 3168901 gcaatataaa tgcaacggtg gctataagaa aaatcattcc gaataatttc atatgttcaa 3168961 ccccttttta gggtatcatt cccgcccaaa ctgtttttaa accaataaaa aaggcgcctg 3169021 ggggagcgcc tgatctttag gttccttact cagtaaattt ttgtgcttct ttttcccaag 3169081 cctgttcgaa ctcatccgca ctgttcgctg aaatatattc tccgccgcca gcgacagctg 3169141 cttgtttcat ctcttcatta cccttgacat caaagttgaa gccaatgatg tttacaatcg 3169201 tatccacatt tgatgcacgg agcttttcga tttccgccgc agggtctccg ccgcacgttt 3169261 cttcaccgtc agtgattaaa tacaccacgt ttttcccgtc tgcgtcaaat gcttcaaatt 3169321 cttttcttgt gtctgcaagt gctttggcaa tcggtgtcca tccagtcggc ttgagctcac 3169381 tcaatgaatt gtcaaacaga gacccttcat atggatgaag gccgtaaatg gtttccgtcg 3169441 tactgcacga aagggcttta ccggacagtt tattgttccc tgcatgcccg aaaacgcgaa 3169501 gcataagatt tgtatccttt ggaagaagtt cggcaaaaga ttttactgat tttttggcaa 3169561 tgtctatttt gcgctctcct cctgtttttt gaaccatgct tccgcttccg tcaaacaaaa 3169621 cagctacatt tgtatcagcc tgtttctcag cggcaaaaga cggggaggca atggaaacag 3169681 tcaacaatcc aatgataccg gcagccagca attttttcat atgattactt cctttctttt 3169741 tcatattttc caactatatg ttggattctt ctttatgcta gaatacgaaa atgcaaaaag 3169801 atataggaca tgctgccttt tgtgctgctt tcacgatctg tccaaaatcg cttgaaatgc 3169861 cgttcatttt tagccatttc cgcccagaaa gcataaacag cttgtgtgat cattcattct 3169921 tttttcgcct tgattatgac agaaaaacgg aaatctgcta ctatgctaca ggcagacagc 3169981 taattagttt tgaagttttt gttacataca aaaagaggct gaccatcacc agcctctttt 3170041 ttcttattta gataacatta gtgattgctg agtgaaaatt ttctcaacat ctttttgggt 3170101 ataagccggg aagtattcac cgccgcctac tttcgcaatt gcgttcagct ggcctttgta 3170161 tccctcttta taatcaaagc cgatcacatt aacagtgata ttgtcttttt gcagttcctt 3170221 tgctgtttta atcgggtttc ctccgcacgt ttcctcaccg tctgtcaaca gatacaccac 3170281 tttttcccct tttgcatcaa gctggtcaaa agaagatttc gcctcgttca gcgctttggc 3170341 aattggcgtc cagccagtcg gcccaattgt attgagagaa ttgaggaagc tttgctcgtt 3170401 aaagctttgg aagccgtata cgttgcgaat ggcttcacat gactgaactt ttccggaatt 3170461 tttattgttt ccttcagagc caaacacgct cattttcacc tgagttcctt ctggcaatga 3170521 gctcgcaaac tttgaaattt cttttttggc tgaattaaat ttagatacac catctattct 3170581 tttcgccata cttccgctgg catcaagcaa gaccgccacg ttcgccggcg ctttagcctc 3170641 cgtttctgtc ttttcagctg caaaagcagg tgaagttaat ccaaaaagca atcctgtcat 3170701 catgatcagt gaaaatcttt tcttcatgtt cgtacccctt taccaatttg tttctgcgtg 3170761 cagatgttca acgctgaaca taatctatcg taatcaacaa aaaccgagaa ataaataggg 3170821 cgggcttccc cattgctgtt gtttactttt gcatagaaac ctatgttttt attagtgatt 3170881 tccacctaac gcccctatga aaagagaaga ttgtccgcct ttcggctttc gttatatgag 3170941 tctgtcgaag tctgtcgaca aatgtggatg actttaccac aatctcaaag cctgaaatca 3171001 ggaaaaaagg actgatcctt aaagacggtc agaagctcct ctaaaccgtt tcagctactc 3171061 ttagataaaa gatattcagg aacagaaaaa gacgcccaat gagcgtcttt ttctactttt 3171121 tcgccatata tttattcaaa aacgcatctg cctcagaaat ttgtgtgcct tggtaatagt 3171181 actttacaat gtcatcaacc gttttgcctt ctttggccat aaaattcgct ccgtattggc 3171241 tcatccccac accgtggcca aatcctctcg tcgtgactgt aattgtgtct ccatttcgct 3171301 tccattcaaa atcggcggag ttgagaccca acttttcacg tatgtctctt cctttcagcg 3171361 tcttgccgtt aatgacggca gttgcgacct ggtggcccgg tgtctcgccg gtaatcttcc 3171421 ctactgcgct agatccatcc agcttgacgc caagcttttg ctgaaattct gccgctgtaa 3171481 aggttttcgt tgccttatat ttcggagact ttttatccca tgggcttttg acgcttttta 3171541 aatatgggat agcacttgtc caataagctt ctgcattctc tgtgtagccg ttgcttgtgg 3171601 agaaaaagga tgcttcaatc ggctggttgt tgtacgttaa gattttgcct tgcgtactgg 3171661 ctaccgcatc tgtgattttc ttcagttttg tctcatagct tgtgccccac tgttttttca 3171721 gctccgcttt gcttttatac acctggaaca tctgtgtatc atccaccagt gagcctttag 3171781 gagcttctac cgctgaattt gacaccatca gtctgacaat aaatgttctg gcggcaagcg 3171841 cctgggcttt cagcgcttca ggtttaaagg ttgccggcat ttcggaggcg acgactccaa 3171901 tcacatactc ttcaagcgga atgttttcta cggattgatt tgcggttcga tagacgggaa 3171961 tagaaacagg tgatgctttc aatgtttctg ctcctttcga tgctggtttc gtgctgactg 3172021 ctgtcttttc tgattctacg ctggcccccg cttccttatt atgctggaat ggtataacca 3172081 agagtgtggg aaccaagaga atcaatgcac atagtacgga tagtgtgatt gcgaattgtt 3172141 tcatattcag ctgcctcctg ctcgggattc gactctagtc tagtctatgg gcagggacaa 3172201 gctaatatga ctctcgtttt ggacagaaac tttatttgtc atttacgtat tcttttttgc 3172261 tattttgcgc ataatgatga taatacacaa aaaataaaaa accagtatgc cagagtgaca 3172321 tactgatttt caagtaagtt tatgcattta agtcagaaac gacttcttta ttctcttgct 3172381 cagaagcaga ctcatcattt acacgttcga tgtctgcgcc cagagcggca agcttctgat 3172441 ggaaatcaac gtaaccgcgg tctaagtgct tcaattcagt aacacgtgtg tgaccttcag 3172501 ccactaaccc cgcaagaatc agcgctgcac ctgcacgcaa atcagtcgct gcaacttcag 3172561 ctccctgaag ctgtacagga ccgttaatga tgacagaacg tccttcaatc ttgatatcac 3172621 cattcatacg gcggaattct tccgcatgca taaaacggtt ttcaaaaacg gtttctgtaa 3172681 tcatgcttgt gccgcttgca cgaagcagaa gcgccatcat ttgtgactgc atatcagtcg 3172741 ggaagcccgg gtgaggcatt gttttgatgt caatcggttt aagctctttc gggccgatga 3172801 cacgcagacc ttcaccttca tccttaattg ttacacccat ctcttccatt tttgcaatta 3172861 aagaggtgag gtgctcagga accgctcctt ttactaatac gtttccttca gtgattgcag 3172921 cagcaaccat aaatgtgccc gcttcaatac ggtcaggaat aatatggtgt tttacgccgt 3172981 gaagcttttc gactccttca attttgatgg tgccggtgcc agctccgcgg atttttccgc 3173041 ccatgccgtt gatatagttt gctaaatcaa cgatttcggg ttcttttgcc acgttttcca 3173101 gcgttgttgt tccttcagct agagcggctg ccataatcag gttctctgta gctcctacac 3173161 ttgggaagtc cagataaatt tttgcgcctt gcagtcggcc ttttacttca gcttcaatga 3173221 agccattacc gactttgatt tctgcgccca ttgcttcaaa accttttaaa tgctgatcaa 3173281 tcggtctgga accaattgcg catccgcccg gaagtgcaac tcttgcatga cctgtacgcg 3173341 caagaagcgg ccccatgaca agcacagacg cacgcatttt acgaacatat tcaaaaggtg 3173401 cttcagtttg caaagcgtat gaagcattta cagtcacttc attattttca aaatgcacat 3173461 ctgctcctaa atgacgcaac acttcgttaa ttgtatatac atcggagagc gtaggtacat 3173521 cacaaattac gcttttttct tcacttgcta ataaagatgc agcgataaca ggtaaaacgg 3173581 catttttagc gccttcaact ttgactgtgc cgtttaactt ctgaccgccg cggacgatga 3173641 ttttttccaa ggtattcccc tccgcgtccc taaattctct atattaatat tcagtcgtaa 3173701 cgattggtgt gccaaccgta acggtatgtt ttccgcccat tcctgcactt ctaagtgcaa 3173761 tttgcaaatt cattttatgt ttcgaggtca taatgtactc ttcccactca tctgtaaacg 3173821 cagaaataga aacgaaattt ggctcaacta catgttctac tgatcttgct tgaaattcat 3173881 ttaataactg atttgctttt ttttgcaaaa caatattcat attatcatct aagtgaccat 3173941 ttagacaagt aaaaataact actttttctt ggaatatccc aagtgtctcc cgttcaaact 3174001 gttcatatgt atcattccag ctatccggtg tctctagact catttgctca tataataaat 3174061 acgaagttgg attgtgtttt ttgagggttg tgacaagctg cagtctaaaa gaagtacgat 3174121 tttttttgtc agtatatgtg ccaattgcct ttatcatttt atcttcccgt gcaatcaccc 3174181 aatcatattg acgatactct tgttttaaac gttgcacttt ttgataaaat tctttttcgg 3174241 tcagtgacaa gttttgtttt gcatgcaatg tccacttatc tattgacaca tcttgacgtt 3174301 ccatcccctc tgccatctgt gctaacggcg ttaattcact cgcatgaatg gtatggaaaa 3174361 cagcaatgac gaagcttaac atgacggaaa tgataatagc gtggcttact tgttttttct 3174421 tcatgttcat ctctccccct tatccccagt tttaccggag gcaagaggcg ccatacgtaa 3174481 aaatcttcgt caaaactcga gctattcgct tcaacccgct tctcccaacc atttaataat 3174541 gttcaaaacc tattaaaata gatagggaag ctgctgtgaa taattgaggt aatctaaaaa 3174601 gaaattggca acggccgttc caatggcgat tgtcagcaaa atcatcagga gtcttgcctg 3174661 cacgactttg ccttttttga ttaacggatc tatattgacg gcttgcaacg cccaccaagt 3174721 cactgctata aaaatcaggt gaacgacaat gccgattgca gcctgctgtc ccaatacact 3174781 catctattac actcctttct ctgcgttcat accctttctt attatataag aagcacagat 3174841 aaagatgata cattttatac agaacggaat aatcagccaa atctagggct aatccccgct 3174901 taaagtgcga ttcttttaca tggtatactt tattggaaag gagctggcaa atgtgaatca 3174961 ttcttttttt cagcctgaaa agcaatatgg tgaggacctg ccaatttttg atcaggaatg 3175021 ggaagcaatt gcattctatt atgattatag acagtcacag attgaagaac tgaatgaatt 3175081 gtgtcagttt tttaacattt ctcttaccta tacgagagaa agccttgaag agcttgaaaa 3175141 cctctatttt caaagtatac aagaactttt gcttgctgat tggaatcttc ctattgaaga 3175201 attcgagaaa atgatcagtg tttatcttat agattgtgtg attgcccgcc atgaagatgc 3175261 tgaatgggtt gtaaaacctt atccctataa agacggcgct tatacacttg gctttagaag 3175321 acatcgcaaa tcgtggcata caatgaatgc ctgtgatggt ttatacctgc gtccaaaaga 3175381 ggatcgcccg ttgctgtcgc tgtttgattc tcttgtgcgt tcataaaaaa atccttctca 3175441 taaagagaag gattttttct tatttccctg ctacatccaa tctgttcaaa gcccgctgta 3175501 acgcaagctc agcccgacga atgtcagtat catctgattg agaattcaaa cgctcctgcg 3175561 cccgctggcg tgcagcttca gcgcgctctt tatcgatgcc ttccgctgtc tcggcagcct 3175621 gggcaaggat ggtgacatga tcaggacgga cttctacaaa accgccgctg acggcaacca 3175681 tttcagtctg cccgtctttt ttcagacgga cagcgccgat tttaagagga gccacggttg 3175741 gaatatggcc tggcaaaata ccgagatcgc cgctttcggc tctcacactc accatttcga 3175801 tatccgcatc gtatactggg ccgtcgggag taacgatatt gactttaacg gtcttcatgc 3175861 ttttaccctc ctaggaccag attaaacttc tacacccatt tcttttgctt tctcaacaac 3175921 ttcttcgata cggcctacaa gacggaatgc atcttctgga agatggtcat atttaccggc 3175981 taagatttct ttgaagcctt gtaccgtctc ttttacaggc acgtaagaac ctttttgtcc 3176041 agtgaactgt tcagccacgt ggaagttctg agaaaggaag aactggatac gacgtgcgcg 3176101 gtgaacgaca agtttgtctt cctcgcctaa ttcatccata ccgagaatcg caatgatatc 3176161 ctgaagctct ttgtaacgct gaagcgttga ctgtacttca cgcgcaaccg catagtgctc 3176221 ttctccaaca atttcaggag caagggcgcg tgatgtagat gccaacggat caaccgcagg 3176281 gtaaataccc atttcagtta atttacgctc aaggtttgtt gtcgcatcca agtgagcgaa 3176341 cgttgtcgcc ggcgccgggt cagtgtagtc atcggcaggc acgtagatcg cctggataga 3176401 tgtaactgat ccaacgttcg tagacgtgat acgctcttgg agctgaccca tctcagttgc 3176461 aagcgtcggc tgataaccaa ccgctgaagg catacggcca agaagggctg aaacctctga 3176521 acccgcttgt gtgaaacgga aaatgttatc gatgaagaac agtacgtcct gtccttgtac 3176581 atcacggaag tgctcagcca ttgtaaggcc tgtcaaagca acacgcatac gtgcgcccgg 3176641 cggctcgttc atttgtccga ataccatggc tgttttgttg attacgccag agtcactcat 3176701 ttcgtagaaa aggtcgttcc cttcacgagt acgctctcct acgccggcga atacagagat 3176761 accgccgtgc tcttgcgcga tgttgttgat taattcctgg attaatacgg ttttacctac 3176821 accggcacca ccgaacaatc cgattttacc gcccttaatg taaggagcaa gcaaatcaac 3176881 aactttaata cctgtttcaa gaatttcaac ttctgttgaa agctgatcga atgaaggcgc 3176941 ctgtctgtga atcggatcct ttttcgcatc cgcaggaacc ggctcattca aatcaatatt 3177001 ttctccgaga acgttaaata cacgtccaag tgttacatca ccaaccggta ctgagattgg 3177061 cgctcctgta tctacagctt ccataccgcg ctgaacacca tctgtagatg ccattgcgat 3177121 tgtacggact gtatcatcac ctaaatgaag agcgacctca agcgttaaat caatacctac 3177181 ttcgttttca cttgcagctg gctgtgaaat tttaatcgca ttataaattt caggcaagtg 3177241 accgtcttca aaacgcacgt cgacgaccgg tcctaatacc tggctaacgc gtcctttctt 3177301 catcgctatc cctcctgaca aaatctttct attctaaagc ggctgctccg ccgacaattt 3177361 ccgtaatttc ttgtgtgatg gctgcttggc gagcgcggtt gtaagaaagc gaaagtgaat 3177421 cgataagttc cttcgcgttg tctgtcgcgt ttttcatcgc cgtcattctt gcagcgtgct 3177481 cacttgcttt actgtcaaga agcgcaccga agattaagct ttctgcatat tgaggaagca 3177541 aaacctccag aacctcctct tcagatggtt caaattcata agacgccgtt ctttttccgc 3177601 cgccgctgcc caaatcagat aacggcagaa gttttttctc cgttacttct tgagtaatgg 3177661 cgctgacaaa atggttataa acaaggtgca attcatcaaa cgcaccgtct ataaacattt 3177721 gaatcgtttg acgggcaaga tctttaattt ctgtaaacgt tacttcatct ccaagtcctg 3177781 ttaactcgga aatgatcgga atctcccgtt tcttaaagaa atcacggccc actcttccga 3177841 tggcaatcac cgcatactca tccttagact gatgacgttc ttgcatggcc tgataagcac 3177901 tccgtaaaac cgaactgtta aaagcgccgg caagaccgcg gtcagacgta atgacaaggt 3177961 atgccgtttt tttcacttct ctgctgagaa gcatcgggtg cttcacgttg ccggaaactc 3178021 ttccgacgtt tgacacaacc tcttggattt tatccatata tggcacaaat gattttgcat 3178081 tgttttcagc acgattcagc ttagccgcag ataccatctg catggctttt gtaatctgac 3178141 ttgttttttt cgttgacgtg atccttgact taatatcgcg taatgaggcc aaagatttca 3178201 ccaccttttc tcttcatctg cgtaaaaaga gagaaaaaga gaaccttttt ctctcatcag 3178261 cattcgagtt agttgcttgg tgcaaatgtg cgtttgaagc cttcgattgc agctttgaag 3178321 tcttcatcag caggaaggtt tcctgttttc gcaattccgt caagcaggtc tttatggttt 3178381 tggtcaaggt acatgtagta ctcttcttca aaacgtctga tatccgccac aggaatatca 3178441 tcgagatatc cttttgtcag cgcataaaga atagctactt gcttttcaac cggaagcggc 3178501 ttgttcagat cctgcttcag cacttcaact gtacgcgcac cgcggttcag ttttgcctga 3178561 gtcgcttggt cgaggtcaga accgaattga gcgaatgctt ccagctcacg gtatgacgca 3178621 aggtcaagac gcaaagtacc tgatactttt ttcatcgctt tgatttgcgc tgagccgccg 3178681 acacgggata cagacaatcc ggcattgatc gctggacgta cgcctgagaa gaacaaatca 3178741 gattgcagga agatctgtcc gtcggtgatg gaaatgacgt tcgtcggaat ataagcagag 3178801 atatctccgg cttgtgtttc tacgaacggc agagctgtaa ttgatcctgc gcctttcgcg 3178861 tcgctaagct ttgctgcacg ctcaagcaga cgggaatgaa gatagaatac atccccaggg 3178921 aacgcttcac ggcctggcgg acggcgaaga agcaaggaca gctcacggta agcggccgct 3178981 tgtttagaaa gatcatcgta tacaacaaga acgtgcttgc cgttgtacat aaattcttct 3179041 gccattgtaa ccccagcata cggtgccagg tacagaagcg gtgccggctg tgacgcagac 3179101 gccgttacaa caattgtata atcaagcgcg ccgtgtttac gcaatgtttc tactacgccg 3179161 cggactgttg attctttttg gccgatcgca acatatacac agatcatgtc ttggtctttt 3179221 tggttcagga tcgcatcgat cgcaacagat gttttacctg tttgacggtc accgatgatc 3179281 agctcacgct ggccgcggcc gattggaatc agtgcatcga tcgctttgat accggtttga 3179341 agcggttcat gaacggattt acggtccata acgcctggtg cagggctttc gatcggacga 3179401 gttttgcttg tcagaatcgg gcctagtccg tcaaccggct ggcctagcgg gtttacaata 3179461 cggccgatta actcttcacc aacaggaacc tccatgatgc ggcctgttct ttttacttcg 3179521 tctccctcac ggatctcact gaaaggtcct aagatgacga tacctacgtt tgattcctca 3179581 aggttttgag ccatacccaa aacaccgttt gaaaattcga caagttcacc ggccatacag 3179641 ttgtcaaggc cgtgcacacg tgcaataccg tcaccgactt ggatgactgt acctacgtct 3179701 tgaacttcaa tatcagattg ataattttgt atttgctgtt ttatcagcgt gctaatctct 3179761 tcagctttga tgctcactta ggtttcaccc cttctatcga ttttccccgg ctaattgacg 3179821 ttcaatgcgc tgaagcttcc cgcttacgct gccgtcataa atccggtttc caatgcggac 3179881 tttaataccg cctattaaat ccgtctgcac ttcatttctg attctcagtg aagcgactcc 3179941 ggcttttttt gcaaacactt gtgataatgg taacatttct gcatccgtca gcggtttcac 3180001 tgaatatacg attgcgtctt ctgtttgacg ggccacattt gcgagtttga taaactcatc 3180061 tgtgagctca gggacaatcg cggcacgatg gcggtcaatc aaaagaaaaa tcgtattgag 3180121 tacggactgt gacaaagagc caaatgcatt ttgaatcagc tcttttttct tcgcagccgg 3180181 caccttcgga tggttcaaca catcattaag cgctttttca ttttgaaata cttgttttac 3180241 aacaattagc tcttcttcta cttgattcag ctgagcggac tcattggcta tatcaaaaag 3180301 agctgatgca tatcgtttag agacagctga tccactcatc ggctttctcc tacctcttta 3180361 agatagtcct ggatcaattt ctcttgcgct tgttcatcca gttctttttc gatcactttc 3180421 gacgcaatca tgacagaaag agacgctact tgctcacgga gagcagaaac cgcctgttcc 3180481 ttttccttca cgatttcagt tcttgctgct tctttcagac gttcagattc tgcacgtgca 3180541 gcctgaataa tctcttcttt ttgcttctct cccagtttct ttgcgttttc gataagagtt 3180601 tgggattcct gtcttgcttc ttttaaaaga acgcgctgct cttcaatcag ctgctgcgct 3180661 tctttatttt tttcttcagc agacgtaatt tctccagcga tgtggtcttc acgctgtttc 3180721 attatgttta atagcggccc taaagcgtat ttcttcagaa gcgctaataa gattaacata 3180781 gctaacagtt ggaacaggat atctccgccg ttaaacgaca atcctagttc aagtggtaat 3180841 tgagacatct actacggcaa ctcccttctg caggtttttc tttgctgatc cagcagccgc 3180901 acttgtctct tttcagccgg caaggcggga tgcttatcag acataaagca atggcgaagg 3180961 ttctcttgga atgatcttcg ccatttttag ttcatataag gcttttatgc ttagccaaag 3181021 aacgctaaga atgcgataac gacagcgata ataggaaggg cttcaactaa tgcgataccc 3181081 atgaacataa gagttctcag ttctttacct gcttccggct gacgggcaat cccctctacc 3181141 gtacgtgaaa caatcaaacc gttaccaata cctgcaccaa gtgcgcctaa accaattgca 3181201 atcgcagctg ctattaaatt catgaaaaag ttcctccttt aaaatgttat ccgtttggat 3181261 ataatgtttt aatgatcatg actgatttta tgagacatgt acaccatcgt cagcattgta 3181321 aagataaatg cctggatagc accaataaat aaactgaatg cttgccatgc cagcatcggc 3181381 agaatggcac cgattgtacc gacaagaccg agagccacgc tttgcgaata atggcttgtt 3181441 gctaatcccg caagcaggcc gagaagaatc tcaccggcga agatgttacc atacagccgc 3181501 aaacctagag tcagcgtatt cgcaaactct tcgatgattt tcatcgggag catgaatgga 3181561 acaggtctta aatagtcttt ggaatattcc ttgagccctt tcatcttcac accatagtag 3181621 tgggttaaag caacaaccat cacggctagc gttaatgtaa tggcaggatc ggctgtcgga 3181681 gacttccacc agagctcatg tccgattgta atagagaacg gcagccccag catattcgac 3181741 acaaatatgt acatcagcaa tgtgacacca agtgccaaga agttagcccc tgtttttaaa 3181801 tccattgtac tgccaataat attgcggacg aaatcaacaa tccattccat aaagttctgg 3181861 gcttttccgg gacggatcga aagcgttctt gtcgtcaata tagcaatcaa taaaacaatc 3181921 acactcgcca cagtaatcat cagaatgttt gtcagattaa aagtaagacc tagaaattct 3181981 atagttctgt aaccatgatt caaagggttt tcacctctct tccattgatg aacgtttaag 3182041 ctggataaag gaatctatca taatgacagg gtatattgtc attaatccaa taactgtact 3182101 tgccatatga aagtattcgg gatttttata ggcaacagcc acagcaagaa tcgcattgca 3182161 ccaccgcgct gcgctcccga gagatcgtat ggactttcct ttctctacag ctctgtcaaa 3182221 agcattcatt cttctgacga gcagtaaaaa attaaacaaa ctgaaaacag ttcccagaat 3182281 aaggcctaaa aaaacggttt tatacgctgt taaaccataa cccagtacat acactgccaa 3182341 aatgaacaat aaatatttgc gttgtctgct aaatgtaagc ttgggatcgt ccatcaatta 3182401 tctgtctcct gatgaaaaaa taatgtatag cttggatacg gcaaaaatca gcggttaacc 3182461 cttagtagaa gacctttttt gaccggcaaa acgggcctgt tcgaaaaaat cattcatccg 3182521 caagccttgc agggatgctg tttcattcgc ttaaataaat cctcataata cgggtttgct 3182581 gagaggattt acattgagga tgaggactat aatgaaagct atgaaaacct tctcataata 3182641 ccctcgttta gcatacaata gcccctaaca tgtgtcaatc tgtttaaagt taaaaaactt 3182701 tttatacttt acgtctccac agaatgttca cattttcacc tataattgta tacagattca 3182761 ccgaatagca aaaaactgga taaaaaaatg aaaccccctt ttggggattt cattttttat 3182821 tttgttccaa acatgcggtc acccgcatct ccgagacctg gaacaatata tcctttttca 3182881 tttaattttt catctagcgc cgcaatgtaa atatcaacgt ccgaatgatg cttctgcaat 3182941 tcttccacac cctccggcgc tgctacaaga cacatgaaac ggatattttt cgcaccgcgt 3183001 tttttaaggc tgtgaatggc ttcaactgcg gaaccgcctg tagcgagcat cgggtcaacc 3183061 acgatgaatt cacgctcttc cacatcagaa ggaagcttga catagtattc cacgggtttt 3183121 aaggtttctg gatcacggta aaggccgaca tgtcccactt ttgccgcagg aatcagcttt 3183181 aaaatgccgt caaccattcc caatcctgct ctgaggatag gaaccactcc gagttttttc 3183241 cctgagatga ctttcgattt cgcagcctga accggtgtat tgatatccac ttcttccaga 3183301 ggaagatcgc gggtaatttc aaatgccatg agtgtagcca cttcatctac taactctcta 3183361 aaatccttcg tacctgtatt ttcattccgt atatatgtca gcttgtgctg aattaaagga 3183421 tgatcaaata cataaacctt tcccatactg tgtttcagct ccttttttat tgtcccatca 3183481 acaattacac acttctattg attctacaaa aaaagacatt gagtttcaag aacatcgtca 3183541 aaaaacccgc cgggcataag cccaagcggg ttttaggatc ttaataatct aattctttat 3183601 ataaaggaaa tttatcagtc agagcagcta cacgctgtct tgcttcttca agttttcctt 3183661 catcttcgtg gtttttcaat gcaagcgcaa tgatagcacc gacttcttct aatgcgtctc 3183721 cgtcaaaacc gcggctggtt acagcagctg taccaagacg gatgccgctt gttacgaaag 3183781 gtttttcagg atcatatgga atcgcgtttt tgttagacgt aataccaatt tcatcaagta 3183841 catgctccgc aaccttacca gtcagtccga gcgaacgaag gtcaacaagg ataaggtggt 3183901 tgtctgttcc gcctgaaacg agctggatgc cctctttcgt taaggcttca gccagacgtt 3183961 tcgcgtttga aatgacgttt tgtgcatatg ttttgaaatc gtcctgcaat acttcaccga 3184021 atgaaacagc ttttgcggca ataacgtgca tcagagggcc gccttgaatt ccagggaaga 3184081 tcgatttatc aattttcttg ccaaactctt cacggcaaag gatcataccg ccgcgaggac 3184141 cgcgaagtgt tttatgtgtt gttgttgtaa cgaaatcagc gtaaggaacc gggtttggat 3184201 gaaggcctgc cgcaacaagt cctgcgatat gtgccatatc caccatgaag taagcgccga 3184261 cttcatcagc aatttcacgg aatttcttaa agtcgattgt acgaggatac gcacttgctc 3184321 ctgctacgat aagcttcggt ttatgagcga gggctttttc acgcacgtca tcgtaatcaa 3184381 tatattgagt ttctttatct acgccgtact caacaaagtt atattgaaca ccgctgaagt 3184441 tgactgggct tccgtgtgtt aaatggccgc cgtgggagag gttcatccca agtacagtat 3184501 cgccttgctc caaaatcgtg aagtacactg ccatgtttgc ttgtgcgcct gaatgaggct 3184561 gaacgtttac atgctccgct ccaaagattt ccttcgcgcg gtcacgggcg atatcttcaa 3184621 cgacatcgac gtgctcgcat ccgccgtagt agcgtttgcc cggatatcct tctgcgtact 3184681 tatttgtcaa aacagatcct tgtgcttcca taaccgcttc acttacaaag ttctcagaag 3184741 caatcaattc gatcttagtc tgttggcgtt cacgctcatt tttaatggcg ttaaacactt 3184801 gttcgtcttg cgcaggtaaa tgtttcatca gcgagatcct ctcctatccg tatcctgttc 3184861 tttgttttta ccatcactat tgtacatggt ttttaaggcc gatgtaaaag attattttta 3184921 aaaaatctaa atttttattg gtaaaaacga atattaataa cttaaattta atttaaagtt 3184981 cggaatttat ttcactatct taaaataaaa gaaaagactg gctatgcagt cctttcattc 3185041 gcactcataa accgcccgca ctccgccgat tagtttcggc cgtgtacgcg ccaatgtcac 3185101 atgagctgaa ccgaggctgt tttgagagac acgcacaggg acagccaccg gtttcagatg 3185161 catgccgata aacgtatcgc ctatatcaat tccggcgtca gcctgaatgg tttcaacaag 3185221 aacaggagac ttcatctgct taaacgcata agacgccatc gctccgcccg cttttggaac 3185281 gggcacggca gaaacggttg gaagcctgaa cagcttggct gtttctgctt cgacgacaag 3185341 cgctctgttt aaatgctcgc agcattgaaa cgccagatgg attcccgttt tttcccggag 3185401 ctcagcaagt ccgctgtaga tgctttcagc gatatctaca ctgcccgatg tgccgatccg 3185461 gctgccggcc acttcgctcg tgctgcatcc aaggacgaag agctgatctt gtttcaattc 3185521 cgcttggtcc tgaaactcag acagcatcgt cttccacgtt tgtttcaact cattcattaa 3185581 acagcacccc tacaggtttt tctcttcata atcggagatt tttccaatac gcgtttggtg 3185641 tcttcccccg gtaaactcag tagtcagcca gatttttgcg atttcccgag ccaaaccagg 3185701 tccgatcacc cgttcaccca tcgcaaggat gtttgtgtca ttatgctccc tcgtcgcctt 3185761 cgcgctgaag gtatcgtgcg ccagcgcgca gcgaatccct tttactttat tagcggaaat 3185821 gctcatgccg atgcctgtcc cgcaaattaa aatgcctctg tcaacttcgc cgctaaccac 3185881 tttttcggcc accggaaaag cataatccgg ataatcgaca gagccgctgc cgcagtcaca 3185941 gcccatatca atatattcaa tttgcaattc gtccattaac tctttgattt catttcgaat 3186001 gtgaacgccg ccatgatccg atgcaatggc tactttcatc tgcttttcct cccagcgtgt 3186061 gtgatgcggc ccgcccgctt tattgaccgc gcagcctgtc cgctctttga ttcacaccat 3186121 atgatgtgct tttcactata ttctactcct tcacgcagga tttgcaaatg acctgtttgc 3186181 agattttctg acaacttatc tacggtcttt tttcagctgt tttgccagct gccgaagaag 3186241 ctcttcaagc tcatctcgcg tttgtttata gatgtcaatt gagccgccga acggatcgag 3186301 gacatcacca tggctgcctg tgacatattc ttttaacgta aacactttat cacgataacg 3186361 tccaaattgg ctggcaatga tctgtttgtg ctgatgggtc atagccagaa ccaaatcagc 3186421 cgattccata agttcttcag ttaatggaga agacacatga ttaagggcaa tgtgtttttc 3186481 aaacagcgct tcgactgcat gaggcgtcgc tttcccatta ggtgaagcaa acacgcctgc 3186541 cgagcggaca ttgacattca gcccttccct ttctgcaatt gatttaaaaa gcgcctcagc 3186601 cattgggctg cggcacgtat ttccagtaca gacaaaaata atatccatgt cagtcacccc 3186661 ttatttttct ctattatata tgaagaaaaa agaaacggcg acttcgtttc ttttattggt 3186721 atattaaatt ggcaaaagca gctttaatcc aaacacgatt aatatgatgc ccccgagcgc 3186781 ttcgctgtat gtgccaagcc atgactgcac ttgttttccg accagcaggc ccagccatgt 3186841 caacatcatg ctgaacagcc cgaacagggt aattgtgagg agcggatgcg agccgtatat 3186901 ccccaagctc aagccgacgg aaaagctgtc aaggctgacg ccgatggcaa acagcaataa 3186961 gcccggccct gccggtgaca tgaatcgttc ttctgactgt ttaaaagagg ccataagcat 3187021 ttgaacccca agaacaaaaa gcagcgcccc accgatataa accgctaaca cgccgaggag 3187081 ccctgacagc atgttaccgg ccgccatccc tgcgagaggc atgatgacgt gaaagaggcc 3187141 gatgatgaaa ccaatataga atatctgctt ctttctaagt ttgaccatgc ccattccaag 3187201 gccgacagaa aaagcatcca tccctaaagc aaacgccatg atgcttaatg taatcagttc 3187261 gcctataaac aaatccgaca tacataaata acccccttgg acacgccccg cttttttagc 3187321 ctatgcgtgt ccaaaaaggg ttagaacatc tgactgcttt cagcgaatca ctcttcctcc 3187381 ggcggctttc atcagcctgt tcataatagc aagaccgaca cctgtatccg gaaaggattc 3187441 cgctataatg aaatccacct tattctcatc aaagctgcgc aaagcatcat acagccctgc 3187501 cgcaacagtc tcaagctgag cccgtcttcc gcagctcttc acataatcag cggaataaac 3187561 gcccgctttt tcttctgtcg tcaggacacc gacccgtctt ccaccctgtt gatattcttg 3187621 aatgaggtgc tgaatgcgct ctgggctgcc ttcgcaaatg gcaagaggcg ctgtcggcgc 3187681 ataatgtgta tatttcatcc ctggagaaat cggcttctcg ttttggtcgc tgagcccttt 3187741 atccacatgg atcggcccga tcaccgcttc aatttgttcc ttcgtaatgc cgccaggacg 3187801 caagagaaca gggatgtcgt ccgcacatga aagcacagtt gattcgaccc cgattccggt 3187861 agggcctcca tccacaatac cggctatgcg gccatccaag tcgtgagcca catgctccgc 3187921 ttttgtggga cttggcttgc ctgatagatt ggcgctcggt gctgcaatcg gcagtcccga 3187981 ttcgcgaatc aatgcaaggg caagcggatg atccggcatt ctaatggcaa ccgtttcaag 3188041 acctgccgtt acacgaggtg aaagcgcatc aggtttgcaa ggcagaatga gcgtaagtgc 3188101 tcccggccaa aaccgtttca tcaatgtttt cgccttttcc ggcgccgggc ccgttaaatc 3188161 ctcaagctgg ctgatatccg caatgtggac aatcagggga ttatcgctcg gccgcccttt 3188221 cgcctcatat atttttttga cggcatccgt attttttgcg tttgcgccta ggccatatac 3188281 tgtttctgtc ggaaaggcaa cgacctcatt ttctcggagc aaagcggctg cttgtgcaat 3188341 ttgtggatca tttgtggata actcgtcagt tacatccaca aaccatcttt tcgttttcat 3188401 ttctgaccaa actccttatt cacaacaata aaacgattgt tttacgcgtg taatcctttt 3188461 gaaagtataa aagatgtcct gtaataaaac aagcgttatc cacaaattgt ggacaacgct 3188521 aataaagaag tggataagta tgtgtataaa ctgcacttat ccagacgctt ttttcatcaa 3188581 aacggctcct tctgtttgcc gcgattcaca gaagtgatca gaagaaaaca gctcctccgg 3188641 tacactctca gctctttcaa aacccatggc cgtcagaaag tccgcagagg aatgctgatt 3188701 tgctactagg tacacggttt tgatctgatg cttttcgcac agcacctcca tgctttgaaa 3188761 aagcgtgacg atgtggcctt ggtgaagctt gtccgatatg acaagtgatc gcagcagccc 3188821 ctggtcacag cttatttttt caataccgag gcatccggca atgtttttct cactgtcctc 3188881 cagcataaga aattgagtga agccttcttt cacgccttca tagctggttt ttgcctgttt 3188941 taaaaatgcc tcgagcacat ctccgtcttt ttcccttgcc acccgcagtt gataaaacat 3189001 ccgttcaccc cgtttttgcg ttctttcttc caatctatga ggcaaatcta tttttagacc 3189061 agatgattag gaaaaaaggt cggaaatcca ttcgactaaa aagaatttca cttctgtgcc 3189121 gtcttctttt tcttcgttct cttctttttt ggctttttcc gctttagcgg ttacgtcctc 3189181 aagcactttt tcagtctgct tttttgaggc ttctttatct tcttgttctt tgacggcttc 3189241 cccgttagaa aaatcaagaa agcagagggg cgggaacagc acacaccacc agttggcgcc 3189301 gtctccgttt ccaagcgtaa tcaaaatcgc ttcatactca ccagcgggat ataccatgtt 3189361 gccgtaaagc tttgtcggaa acgagatttt gtcaaaatca acggatatcg actgattcgc 3189421 tccttctttc tccattgttt cctttgcaat tgctttgatt tcaggcagct ttgaacgaat 3189481 cacgcgacgc gcttcttcaa tagaagtaat atcctttacc caagttgtga tttctttatt 3189541 caccgcgtct cttatatgac gttttaattg ctggtcttga tcactatcgc tgtttgccag 3189601 tattctcaaa cgaatcgcct gatcaggtat gaccaccggc tgattttccg atttttgtgc 3189661 cgtctcttct tttgccagcc ctacgagcgc tccggataat aaaagaaaga tatatataca 3189721 aatgattact gtttttttca tcggtcccca ccgttcctct ccgtgctttg tttctagccc 3189781 tattatggac aaggagagcc tgggataaac gtgcagggtg aaaaaaatct agcaagctgt 3189841 taatcttatt tatggtacga tagtgtttta ggaggtttaa gatgaaatac aattatacag 3189901 tgctgttatc agcattcacg atgtccgttc tttattcagt aatttatatt cattcattta 3189961 tcattgccgc tctcatcaca atggcatttt attttctgtt tccttatttg atcttcgcac 3190021 tgccgcttca aatcatgatg aataaaaagc cgaaacgttt cagccctttg tatctgctgt 3190081 attaccttgc cgctgctttt attgccaacg cgatcatttt cggcatgctt cagccttcgg 3190141 gacaatctct gtttcaaaat acagcctttt atcttttcgc tgtattaaca gctcttatct 3190201 attggatatg ggattctgtt ttactgcaaa aaaaggaagc ctaagaggct tcctttttta 3190261 ttaaaacaaa atcgtcagta aataacatag aatggaaggt atcgccgcaa caaagaaagc 3190321 ggccgccatt ttcatgcgag atgtacggcc ttctttggtt tctgaatggt agtttgcccg 3190381 ctgatcgctt ccgcttacag ccaaacccga tgtaatgatc gcgagcccca ctaaaacgag 3190441 agacgcaacg ccaaaaatcg cttcatatga aagagcctgc ggaaaaatgg tgccaatcat 3190501 gctctcaatc gcaatgagca ggattcctgc tgtcagggcc tttttcatgt ttacatcccc 3190561 tttgctggtg ttaaacagct tgatccattc actcgccagc aagctgctta tttattttta 3190621 tgaatcagag cgcatatggt tctgtctttt ccattaatat ctttcagcac ttccacttcc 3190681 gcccccttaa acgccttgag gatcaggtct ttgaccgccg ctccctgttt ccagccgatt 3190741 tcaaaaacga caaatacttt atccttcata acaagcggaa tgtcttccat aaaccgctta 3190801 taaaatttca gcccgtctcc gccatcggtg agtgcgtgca gcggctcatg aaaacggaca 3190861 atttccgata aatcagccat ttcttcctct gaaatatatg gcgggtttga gacaatgata 3190921 tccgcttttt ttcccgcctt aataaaaggc tcaagcagat cgccctgata aaagcgcaca 3190981 ttcgctccga gtttttctgc attggcagag gcgacttgca gcgcctcttt cgaaatatcg 3191041 accgccgaca cagaaaagct ttggttttca agcgcaagcg tgacggctat tgcgccgctc 3191101 cctgtaccaa cgtcaacaac ttcgagcttg ccgtcttcag aaaaaacact ccgatatttt 3191161 tcaagcaaat gaaagacaac ttcttcagtt tccggccgcg ggatcagcac atcatcattc 3191221 accataaatt cccgtccata aaaaaactct tttcctataa tgtattgaac cggcacgccc 3191281 tctttatgca tctcaacgtg acgcttaaag cgatacagtt cgtcttcacc aatcggttcc 3191341 tgtaagcttg cgagcagctt gcttctctcc attccggtat cataaagcaa taggagctcg 3191401 gccgcatttt cttctcttcc cgcttcggtt aaataagaag aagcccattt cagggcttcg 3191461 aatatcgtct tcatcttaac cttccgactg ctgaagcttg cttgcctgat cttcaacaat 3191521 cagcgcttca accacttcgt caagttttcc ttcaagaatc tgatcaagct tttgaatcgt 3191581 caaaccgatt ctgtgatccg tcacacggtt ttgcgggaag ttgtatgtgc ggatacgttc 3191641 agagcggtca ccagatccga ctgctgattt ccgtgtttga tcatattcag cctgggcttc 3191701 ctgctgaaat ttatcataga ttctggcacg gagaaccttc attgcttttt ctttgttctt 3191761 aatttgagat ttttcatcct ggcatgatac aacaacacct gtcggcaagt gagtcagacg 3191821 aaccgcagac attgttgtgt taacgctttg tccgcccggt ccgcttgaag caaatgtatc 3191881 gacacggata tccttctcat ggatgtcgac ctctacctct tctgcctcag gaagacatgc 3191941 cactgttgca gtggatgtat ggatgcgtcc gcctgattct gtttccggaa cacgctgtac 3192001 gcggtgggcg ccgttttcat atttgagttt agaatacgcg ccgcttcctg taatcataaa 3192061 gatgatctct ttgtagccgc ccgttccggt tacattcgct tccatgacct ctgttttcca 3192121 gccctgaagc tcagcataac gggaatacat tctgtacaga ttgcccgcga ataaagcggc 3192181 ttcctcgcct cccgcagccc cgcggatctc catgataacg tttttgtcgt cattaggatc 3192241 tttcgggatc aggagcacct tcagccgttc tgacagtgtt tccgtttcct tctgaagttc 3192301 agaaatctct tccttcacca tgtcgcgcat ctcagcatcc agcttctctt caagcatcgc 3192361 ttttgcatca gccagctgtt ctgacgcatc tctgtattgt ctatatacgt caactgtttc 3192421 ttgtatatca gattgctctt ttgaatattc tcttagcttt ttcggatcgt tgactacttc 3192481 tggatcgctc aaaagctcat ttaatttctc gtatcgttct tcaattgatt ttaaacggtc 3192541 taacacggtc ttcacctctg ttttcctgtg cgtaacattc tcattatagt atagtgatta 3192601 accccagtca aaagcatttc aatcccagct ggaaaagctc cctctgctat actggaattc 3192661 gaggagggat gatgttgctg aaatccatac atcatattgc aatcatatgt tcagattacg 3192721 aaaagtcgaa agctttctac gtacataagc ttggttttca ggtgattcaa gaaacgtacc 3192781 gcgaagagcg cggctcctat aagcttgatt tgtcgcttaa cggctcgtat gtcattgagc 3192841 tgttctcgtt tcccgatccg cccgaacgac aaacccggcc tgaagccgca ggcctgcgcc 3192901 acctcgcctt tacagtcggc agcttggata aagctgttca agagcttcat gaaaaaggaa 3192961 tcgaaacaga gccaatcaga acagatccgc tgaccggcaa gcgtttcacc ttcttttttg 3193021 atcctgacca gcttccatta gaactgtatg aacaataaca gtttttgaag aaaaaaagga 3193081 gatacccact ttctttgccg aatcttttct tgttttgtct aacgggaagg gaaccgcatt 3193141 ctatggtcga atacctagct taaaaggagg tatgggatca tgaatacaaa tatggtagca 3193201 agtgaactcg gcgtctccgc aaagacggtg cagcggtggg tgaagcagct gaatcttccg 3193261 gccgaacgca atgagctcgg acactattcg ttcacggcag aagacgtgaa ggttctaaaa 3193321 tccgttcaaa aacaaatctc tgaaggcacg gcgattcagg atattcatct gccgaaaagc 3193381 gctaaaaagc gcacaggctt ccttgtccaa aaaacaagta gcgacacaga acgaagaatc 3193441 gagcagcttg aacaaaagct ggacaccctt ttacagcaaa ggcaggacga aagcgaattg 3193501 atggcaagga tgtcggaact ggaacgccag ctgaaacaaa aagccgatga aggtgtatct 3193561 taccagctgc ttcagcaccg cagagaaatc gatgatattc ttgcagatct gcaatcactg 3193621 acctcacaaa tgaaagaatt caccgctcat tcgatccccg agactgctgc tgcttctgaa 3193681 aaaaccaaaa caagaaaaaa accgctgctg tcactgttca aatttcaaac ctaaagcaaa 3193741 aagctccctt aaagggagct ttttttgtta cgcagtaagc gcgataatga ttggaagtga 3193801 aatcaatgac agaatcgcac tgaccacaaa cgcagttgca gtttcttctt cttgtttctc 3193861 gaaacgagtc gcaatcatgg ctgcaacggc agaaccaggg aatgcaacaa gaaggattgc 3193921 ttttgttgtt tggtcagctg gaagtccgat agcaagagca atcaggaaca ttaacgcagg 3193981 ctgaaccgca acttttagta acgcaatacc gatagccggc atactgagtt taattttacg 3194041 aataccaacg gtaacaccaa cagcgaagag agcaacacca gatgttgtgc ttccaagctg 3194101 atcaagcatt ttaacaccca gctcaggaag agtgaaattg aaaaccagca ccaagatcat 3194161 actgattaac ggagcagctg caagcggctc acaaagacca tgcaggattg attttcctgt 3194221 catcttccag aagctgtcgc cactctcttc gtttttctta gaagactcac caacagtagc 3194281 gataatgatc gcgagcggat caagaatcgc gttaaccacg atacctgtga ccgcgatcgg 3194341 aatcgcaact tcattcgctc cgaataagct tcccaatacc gggataccca taaatgcgaa 3194401 tgtcggctgt gcagagttca aagaaaatac agatgagttc gttaaatcat acttgaatat 3194461 aaatctgcaa accaaaagaa tgatgatata gaaaccaaca atcccaataa ttaaagaaat 3194521 cattaaaggt acttgtgata aaaattcact tctggaagtt gtcaaaatac cagcgataaa 3194581 gtgagctgga agtgcgtatt tcgttactaa cgtacttacc ccttttgccg acttggcatc 3194641 ataacttcca aaatgtcctg caaaccaacc cagcacgata acaaagaaga tcggcgccag 3194701 gaggattaag atatctaaga tgctcaaaat attctcctcc aaatcctatg tccgtatact 3194761 ttagctttac aaaaagcttt ccctcggaca gaaaaattta ctcgctaatt atttcgcgat 3194821 gacttttttg tattcaggtg tccacattgc atcaagtacc gcttgtttca catcttcagg 3194881 ctgacgattt gccacgccgt ctttaattgc tgcttcagca acggcaatcg caacttggat 3194941 agaaacctct tgaagcttat caatgcttgg aagcaatcct gctccaggtg tttcaagatc 3195001 aaccatttca gcaatcgcat cagcagttgc agcaaacata gcaggtgtaa tgatacgcgc 3195061 ttcagctaca attgaaccaa gtccaagacc agggaacgcg aatgcgttgt tagattgtcc 3195121 gatttcataa gaaacaccgt tgtattctac attgtcaaat gggcttcctg ttgcaataag 3195181 cacttttccg tcagtccatt tgaacagatc ttcaggaaca gcttcagcaa ggtgagtcgg 3195241 gttagacatc ggcatgataa ccggacggtc tacgtgagat gccatttctt ttacaatttc 3195301 ctctgtgaat gcacctgaaa cccctgaagt accaatcaag attgttggtt tcgcttgacg 3195361 aacaacttca tcgaatggaa tttgaccttt ttcatcgcgc ttccagtctt tcacttcatc 3195421 cgcattgcga aggtaaggtt tttggaaatc aaggatgcct tcgatgtctt cagtcagcaa 3195481 gcctctgtaa tcaagtgtgt agaaacgttt gttagcttct tcttcagata atccggctag 3195541 caccattgtg tcacggattt ggtcagcaat accgatacca gcagaaccag caccgaagat 3195601 aacaacacgc tgatctttaa tagaagcgcc ggttttcttc atagcggcaa gcacacctgc 3195661 aagtgtaatc gcgccagtac cttgaatatc atcattaaat gtcaggattt catgattgta 3195721 ttttttcatg atgttgcgtg catttttgtt gccaaggtct tcccagtgaa gaagcgcttt 3195781 agggaagaat ttcaatgcag cttttacata agcgtcaatg aaagcttcgt agcgttcacc 3195841 ttgaacacgt tcatgcttgt taccaatata taaaggatcg tttagaagtt tttcgttgtt 3195901 cgtaccgaca tcaagcacaa ccgggataac acggctaggg tcaataccag ctgcagcagt 3195961 gtagacagcc aatttaccga ttgcaatatt aataccgcct acaccccagt caccgatacc 3196021 gagaatgctt tcggagtcag tagcaacgat aagatcaata tcgcctgctg tcgcatgaag 3196081 gttttcaaac gctttttcaa taccgtcaat gttatcgatt gacaagtaga ttccttgagg 3196141 tcttctatat tcatggctgt attcctgaat cgcttcacca actgttggcg tgtacacaac 3196201 aggaagcatt tcgcgaagat ggtttttcag caatttatag aaaagaactt cgttacggtt 3196261 tgcaagatca cttaagtaaa cattttgacg aaggcggtca ggctgcgctt ggaattgctc 3196321 gtacgcgcgt tgtgcttgtt gatcaagaga aagtacagtt ggcggcagaa gcccttctaa 3196381 gccgagttct tgtctttctt ctagtgaaaa agcaacgcct ttatttaaag taggaataga 3196441 taaaacttct tttcctctaa gagttgtttc taagtggcct tctttcgttt tttttatgtt 3196501 attcaagcaa atctccttct ttcttgaaat agttaaccaa gttaagtaat aacccatcta 3196561 aaatatgacc gatcatgatc tttatgcgac tttgtgacaa ttattcgaac aatgtctcaa 3196621 aactatttac attacgtaag ctattgtatg cctgtcaaaa tcaaaattca agagaagaaa 3196681 attacttaat tttttaatat acttatttaa attttttaat tgaatattat cagaatataa 3196741 aaaaaacacc ggtgttttta gccggtgcat tctatcttta tacccatgtt ttggactatt 3196801 ttttagattt acctgggact tcgtgatgat gtctgcatct tgcttcatat gattcagctg 3196861 caccaaccaa aatgaccgga tcatcgtaag aagcaggttt gccgtcaatg aggcgctgtg 3196921 ttctgctcgc cggtgatccg caaacagaac agacggcttg cagctttgtc acactttccg 3196981 caatcgccat gatattcggg acgacaccga acggctctcc cctaaaatcc atatcaaggc 3197041 ctgctgctat cacacggtag cctttatcgg caagagatga taaaacctca acaatttcct 3197101 gatcaaaaaa ctgcacttca tcaaccgcaa ccacatctgt actttcactg atgtgatccc 3197161 aaatgtccgc agcagacgaa atggcatagc tcgtcatcga tgttccatta tgggagacaa 3197221 cagcagcttc gctgtatcgg ttatcaatta caggcttaaa taccctgact tcctgcttgg 3197281 cataagttgc tctcttcact cttctgatca gctcttcaga tttccccgag aacatgctgc 3197341 cgcaaatcag ctcaagccac ccgctttgtt tcattatgta cataggcttc gctcccctct 3197401 ctctgccagc tgtgttttag acaatataaa aaacaggcaa gactgctgct tgcctgttga 3197461 gaaatctatt attacttaag accgtatttt ttgttaaagc gatcaacacg accatcagca 3197521 gaagcgaatt tttgacggcc agtgtagaat gggtggcatt cagagcaaat ctcaacgcgt 3197581 acctcttctt ttactgagcc tgtttcaaat tcatttccgc aagcgcattt aactgttgct 3197641 tttttgaaat taggatgaat tcctgctttc attgtatcca tctccttccg ccctgaatcc 3197701 cgtgtggaaa cagagttatt atttcggagc attgtccgaa acgcatatga gaaaattata 3197761 tcagtgattt acttcttttg caaatacaat ttaccttctt gcagatgata gatttgcctg 3197821 tttccattct tgattgagaa tatcgaaaaa ttcctggttt gttttggttt ttttcatttt 3197881 tctcatgaac ttttctgcga aatcaggtga atcagacatc gttttgcgga tagaccataa 3197941 acgatcaaga tgctctttag gcacaagcag ctcttctttg cgcgttcctg aacggcggat 3198001 atcgatggca gggaagatgc ggcgctcggc aagagagcgg tcaagatgga gctccatgtt 3198061 gcctgttccc ttgaattctt cataaatgac atcatccata cgtgaacctg tatcgaccag 3198121 agccgtagca aggatggtta agctgccgcc ctcttcgata tttctcgcag ccccaaagaa 3198181 gcgtttcgga cggtggaacg ccgctgggtc aatccccccg gaaagcgttc ttccacttgg 3198241 cggaatcact aagttgtagg cgcgggcaag acgtgtgatg ctgtccatca ggataatgac 3198301 gtcttttttg tgttccacga gacgcatcgc acgttcaagc acaagctcgg ccactttgat 3198361 atggttttcc ggcacttcat caaacgttga gctgacgaca tccccagcta cagagcgctc 3198421 gatatcggtt acttcctcag gtctttcgtc aattaaaagc acgatcagct ctgcttcagg 3198481 ctggttcgct gtaatgctgt tggcaatttc cttcagcaac atcgtttttc cggctttcgg 3198541 cggcgcaaca atcaatccgc gctgcccaaa tccaaccggc gccatcatgt ccataattct 3198601 tgtagacaag aagttcggct ttgtttcaag caccatttga cgatccggat aaagtggcgt 3198661 aagagccggg aaatgcacac gctcttttgc agattcggga tcatccccat ttactgcttc 3198721 aacgtgcaaa agtccatagt aacgctcatt ttcttttggc gggcgaacct tgccagatac 3198781 tttgtctccg ttccgcaaat cgaaacggcg gatttgtgaa gctgagatgt aaatgtcttc 3198841 tgagcttgga gagtagttga tcggtctcag gaatccgaaa ccttcagact ggatgatctc 3198901 gagaacgcct tccataaaca gcagatcttc ctgttctgca ttcgctttca gaatggcgaa 3198961 aatgagttct ttttttgtca gtttgctgta ataggagatt ttataatgtc ttgcaagttc 3199021 ataaagctct ttcaatttca tattttccaa agaggaaata gatacgtctt tcataaaaac 3199081 accacgcttt tcatagtcaa tatcttactc tgaacatgtc atctgctgct tttgcacaac 3199141 atccgccaaa gcacattctt tttttaacat aaaggaactt ctatcggtaa cacttccacc 3199201 catgatcggc gcttttgtta aaaggattgt cttaatgagt tttgaaggaa gcgaggacaa 3199261 aaacatgaga agatcaatac ttatatcgtc tgtatgcggt agaaattgaa actttcctag 3199321 tgcttaaaag aaggtattac gcagtaaaat tcgcagcact ctttattttt accttatttc 3199381 aaaaaattat tcaactgaaa taaggttttg acacggaatt gatagagttg acgcttttct 3199441 gcaaaagtta aagcgggctc acacccgctt tttctgtttg ttatggacgg attacaagat 3199501 ttggtttctt tttcaagctg tgtctgccgt caacgaaacg aacagtgccc gattttgcac 3199561 ggataactaa gctttcagtt gtaccgacag agcctttgaa ttgaactcct tttaacagct 3199621 cgccgtcagt aacccctgta gctgcaaaaa tcgcgtcatc acccttcaca aggtcttcca 3199681 tgcgaagcac tttgcttaaa tcaaggccca ttttgtgaca gcgagtgatt tcttcttcgc 3199741 tttgcggaag aagtttacca atgatttctc cgccgagtgc ttttagcgca acagcggaaa 3199801 gcacaccctc aggagcgccg cctgatccga acaggatatc aacgcccgtg tggtcgaaag 3199861 ccgtgttgat ggcgcctgcg acatcgccgt cattgatcaa tttgattctg gcgccggcct 3199921 cacgaagctc ggaaatgatt tttgcgtgtc tttcacggtt taaaattgtg gcaacgacgt 3199981 cctcaacgtc cttgtttttc gcttttgcca ccgctttaag gttgtcaatg acaggtgctt 3200041 cgatgtcaat gcagcccacc gcttccggac cgactgcgat tttttgcata tacatgtcag 3200101 gagcattcag aagcgtgcca tggtctgcga ccgcgataac cgtcagcgcg ttccagccgc 3200161 cgcttgctaa gatgtttgtg ccttcaagag ggtcaactgc gacatcaacg cgagggccgt 3200221 acccgtttcc gagtttttcc ccgatataca gcattggcgc ttcgtccatt tccccttcac 3200281 cgattacaac ggtccctttc atcggcactg tatcaaaaac gtctctcatt gcacttgttg 3200341 ccgcttcatc agcctcatct ttttttcccc ggcccatcca tcttgctgat gccaatgccg 3200401 cagcttctgt cacacgtacc aattccattg ataaacttct ttccatttca acacgatctc 3200461 ctctcacaag aaaccattat gaattttgaa gctgttctat ttcttcgtca gtcattcttt 3200521 cacgccaaat tgtcgctcca agcccctcaa gcttcttctc aaggctgctg tatcctcggt 3200581 caatatgctc cagtcccgta atttccgtga cgccatcagc catcagtccg gctaccacca 3200641 agcaggctcc ggcacgcaga tcactcgcct tcacttttgc gccttgaagc tcgacaggac 3200701 ctgtgatgat ggcagatctg ccttctactt tcatattggc acccattcgt ctcagctcat 3200761 caatgtgctt gaatcttgcc gagtagatgg tgtctgtgac gacactcgtc cctttcgccc 3200821 ttgtcaggag cgccgtcatc ggctgctgta aatcagtcgg aaaccccggg tatacgaggg 3200881 ttttgacgtc aaccggcttt aagttcttct gcccgccgac aatgaggagc tggtcgtcgc 3200941 ttgtttcgat atgatagccc atttctctca gctttgccgt taacgactca agatgagtag 3201001 ggatgacgtt atcgataatg acttccttgc ccattgcagc ccctgcaatc ataaatgtcc 3201061 cggcttcaat tctgtccgga atgatcgtat gcttgcagcc gtgcagttcc ttcacgccgt 3201121 cgattcgaat cacattggtg cccgcacctt tgattttggc gcccatgctg gtaagcaatg 3201181 tcgcgacgtc aatgatctca ggctccttgg cagcgttttc gatgatcgtt ttcccttctg 3201241 ccaaaacagc ggcgagcata atgttaatcg ttgccccaac gcttacgaca tctaaataaa 3201301 tccgtgcgcc tctcagcctt tcagctcgca aataaatggc gccttgttca ttggttactt 3201361 cagctccgag tgcttcaaag cctttgatat gctgatcaat cggacggggc cctaagtgac 3201421 agccgccagg caatccaatg accgcctgct tgaagcggcc gagcatcgcc cccattaaat 3201481 aatatgacgc gcgaagcttt tttactttcc cgttaggaag cggcatgctg atcatcgacg 3201541 tagggtcaac aaccatttcc ccattctcaa aatgcacgtt gccgccgatt tcctttaaca 3201601 ggtcacgcag cgtttcaata tctgaaatct ctggaagccc ttcaattgtc acctcggaat 3201661 ttgccaaaat ggttgcaggt attaacgcaa cagcgctgtt tttagcgccg ctgatatgta 3201721 ctgtaccgtt taacgagtca ccgccggcaa tattcaactt ttccatgata gtctccttcc 3201781 ataagaagat agctgcggag ctaaataaaa tgtcatttta ttctgtctct gcaaataaag 3201841 ctcatgtcca aaatctagcc aattcgaaga gaaagaatac aacacattgt aaaatatcag 3201901 gaagaaaata gcgaagcttt ggggggtaca ggtttcaaaa gatgcacaga gacccgccgg 3201961 ctcgagagac atcgtcgtca tccggcaaaa gcagtacgca tacccttcat tccgatatca 3202021 gcttctgcag cccaatgatt ccttctctgt aaagcggcgt cagcatctga agatccgctg 3202081 tatcaggtcg gtgaaataca aaggccgcgg caaacaggca taaagctgtt tgccgcccct 3202141 ttcattattt gttccagtct gccaggaatt gttcgattcc tttgtctgtt aacgggtgtt 3202201 tagtgagcgc atgaatgact ttcagcggca ttgtgccgat atgagcccct ctaagagcag 3202261 cttctgtcac gtgctgcgga tggcggattg acgctgcaat gatttgcgtg tcaaggccgt 3202321 gaatgtcaaa aatctgttta acttctgaaa tcaggtcaag cccgttgtgg ccgatgtcat 3202381 ctaaacgtcc caggaatgga gatacatatg ttgcccccgc tctggcagca agaagcgcct 3202441 ggttggcatt gaagatcaat gtaacgtttg ttttgatgcc taagtcagta agtgctctta 3202501 ccgcttttaa accgtcagac gtcattggga ttttcaccgt aatgttcgga gcgatcttcg 3202561 ccagttcttt tccttcctcg atcatttcct cagctttcaa agaaataacc tctgcgctta 3202621 cagacccttt cacgacgtct gtgatctcgc gaagacggtc gtggaatgat acgttagctt 3202681 cctttgctac taaactagga ttcgtcgtta caccggcgag aattcctaat tcattcgctt 3202741 ctctaatttc atcgatattg gctgtatcaa caaagaataa cattttcaaa aagcctccct 3202801 gattaagaaa ttttctgaac tgcgaatatg attgcgcttt ctaaagatag acggaaaacc 3202861 gcctgtcaag ctgtcaggcg gctataaaaa gttccaattg aattaagctt ggtttgaaga 3202921 accaaattca cgcattttac cgataactgt ttctttgatc gcttcacgag ctggtccaag 3202981 gtatttacgt ggatcgtact cgtcaggctt agctgccaat gtttcgcgaa cagcttttgc 3203041 agaagaaatt tggttttcag tattcacgtt gattttagct gtaccaagtg aaattgattt 3203101 tttgatgtca gcagtcggaa ttccagtacc gccgtgaaga actagcggaa ggccagttga 3203161 ttttccgatc tcttccattt ctttgaagcc aaggtttggc tcacctttgt aagggccgtg 3203221 aacagaacct aatgcaggtg caaggcagtc gatgccagtg cgctcaacaa gctcttggca 3203281 ctctttagga tcagcgtaga ttacgccttc agcgataacg tcatcttctt gtccgcctac 3203341 tgttccaagc tcagcttcta cagatactcc gtggaaatga gcaagctcaa caactttagc 3203401 agttgttgct acgttttctt caaatggatg gtgagaagcg tcgatcatta cagatgtgaa 3203461 acctgcatga atcgctttcg cacaagattc aaagcttgaa ccgtggtcta agtgaatcgc 3203521 aacaggaact gtcactttgt actcttccat aagtgctttt accatagcaa cgactgtttt 3203581 gaagccgccc atgtagcgtc ccgcaccttc ggaaacacca aggatcactg gagatttttc 3203641 ttcttcagct gcttgtaaaa tcgcttgagt aaactcaagg ttgtttaagt taaattgtcc 3203701 tacagcgtac cctttttctt tagctgtatt caacatttcc gtcatagaaa ctaaaggcat 3203761 gtcgaatgtc ctccttatgt agcctgattg tcttctagcg aaaaaagctt tccaccctag 3203821 catgacccat atattgctgt catatgtaaa tactcagatc gctttttctc cataactagg 3203881 ataccaactt ttcgacaaat cggcaacata atgacatgat tcatttgttt cttctttttg 3203941 tcagttagac ttcaggggca gatatttttt gacggcgtct ctgatttcgt cgatgtcaaa 3204001 cggcttggca aagtgcgtca gagcgcccaa ttccttcgat tcctggatca tgtcgagctc 3204061 tccgtatgcc gtcatgataa tgacccggat gttttcgtca atgaccttca tccgttttaa 3204121 gatttcgatt ccgtccatgc cgggaatttt catgtccaac agcacaaggt cgggccgttc 3204181 ttttgtcaca atgtcaagcg cctgcaggcc gttcgcagcc tgaaacgtct ggtagccttc 3204241 tttattgaac acttcattta gcaaaatacg aatgccgtat tgatcatcaa cgattaaaat 3204301 tttttcattc atcattttac accccaatat tatgattttc gtcaaaagta agcagtattg 3204361 tatgtattct gtttgatttt cctatttcct ttaattataa tagtctactt tacgacattt 3204421 tctgagcatt ttctcttttg ttgtatactg atattgtacg ttataaagga ggattcactt 3204481 atgttgaaaa tattcacgac gcagttaaca ggtatttttt cccgcattca ggataaggaa 3204541 tctgacgcga ttgaagatgg ggcgcggctg cttgctcaag cggtgatcag cgggcattcc 3204601 atttatttat acggagcgaa tgagcttcag ggcgtctttt atgaggccac cgaaagcaaa 3204661 gaacccttcc catctgtcaa agcctttcca gaaaacgctg aggaagtgac agaaagcgac 3204721 agggtgctga tgttttgctc agggacgggc acagccgaag aacaggagct cgcaaaagag 3204781 ctttatgaaa aaggtgcggg agtcgtatgc gtatcgcccg cagccaaaga cagtgcggga 3204841 atagaacagt attgtgatgt gcatattgat tctaaattaa aaatgccgct tgttcccgat 3204901 gaagacggca cccgttacgg gtttccctct ttaatgacag cactgtatgt ctatcacgct 3204961 ttatcgttta cactaaaaga aattctgcaa gagtatgcat aatatcttat tgtacatgct 3205021 ggaacttgcc ggaaacaaat aaaaaagact tgcccgcttt tgacaaacgg caagtctttt 3205081 ttattacttc tgatttgcag cttcgacaga cgctccgata aagcctttga atagaggctg 3205141 aggtcttgtc ggtcttgact tgaactctgg gtggaactga gaagccacga accaagggtg 3205201 gtctttcagc tcgatgattt caacaaggcg tccatcaggg cttgtgcctg agaatacgaa 3205261 gccttgctct tccatttgct gtctgaattc attgttaaac tcatagcggt ggcggtggcg 3205321 ctcgtacacc acttcatcct gatacacttc aaaggctttc gtgccttctt caagcttaca 3205381 agggtaaagg ccgagacgaa gcgttccccc aagatcctca acatcctttt gttcaggaag 3205441 aagatcaatg atcgggtatt gagttgacgg atcaatttcc gctgagtgag cgccttttaa 3205501 gcccaatacg tttcgtgcgt attcaataga cgccacctgc atgcccaagc aaatgcccaa 3205561 gaacggaatg ttgttttcgc gcgcgtattt tgtcgcgacg attttccctt caacaccgcg 3205621 gtctccgaat ccgcccggca caatgatgcc gtctgttccg cttgtgagtt ctgcgatatt 3205681 gttttctgtc acttcttccg cgttgatcca cttcactttt acatctgtgt caaacgcata 3205741 gcccgcatgg cggagagact cgacaacaga aatgtatgcg tcaggaagct caacgtattt 3205801 gccgacaagg ccgattgtaa tcgtttgaga caggttgctg actttgttaa caagctcttt 3205861 ccactcggac atttccgctt ctttgcatgc caatttcatg tgctcgcaaa caagcttatc 3205921 aagcccttgt ttttgaagct ccagcggaat ggagtaaagg ttgtccgcat cttcacattc 3205981 aataaccgct tttgtatcga tgtcgcagaa aagcgcgatt ttatctttca tatcttgaga 3206041 aatcggcatt tctgtacgaa cgacgatgat gtttggctga atgcccaagc tgcgcaattc 3206101 ttttacgctg tgctgtgtcg gttttgtttt taattcgcca gcagctttaa tgtaaggcac 3206161 gagcgtacag tggatgtaca ttacgttttc acggccgatg tcgctcttca tttggcggat 3206221 cgcttcaagg aatggcagtg attcgatgtc tccgacagta ccgccgattt ctgtaatgac 3206281 aacatctgcg tttgtctctt tccctgcgcg gtaaacacgg tctttcaatt cgtttgtgat 3206341 gtgcggaatg acctgtacgg ttcctccaag gtaatctccg cggcgttctt ttttaagaac 3206401 tgttgaatag attttacctg ttgtcacgtt gctgaattta ttcaggttaa tgtcgataaa 3206461 acgctcatag tgaccaaggt ccaagtctgt ttcagcgccg tcatccgtta cgaatacttc 3206521 accgtgctgg tacgggctca ttgttcccgg gtcaacgttg atgtatggat cgaatttttg 3206581 aatcgtcacg ttcagtccgc ggtttttcag caaacgccct aatgaagctg ctacaatacc 3206641 ctttccaagt gaggatacaa ctcccccggt tacaaaaata tatttcgtca tttcgtttgc 3206701 tcctctcttc gctcttagct acatttttaa aatgtactat tttataaaaa atcatttagc 3206761 cttttaaatg atttataaga aaaatgaggg gtgaaaataa gaaagctccc tttcaatttc 3206821 ttgaaaggga gcataacgta ctatgttctc tcttcgtttt tgaagagccc aaaatacata 3206881 ctacatagtt cgactatgaa agtcaagatc gttttgaaga tgaaatctga tactatttaa 3206941 tttcctcttc ttcatcatca tagtcttcat catcttcatc aataatatct tcttcgatct 3207001 caagatcatc gtcgtcttca tcaagatctt cttcgtcaaa atcgtcggct tcaagatcga 3207061 gttcttcctc aacttcatcc aaatcaaggt cgtcttcgtc gatctcttca aactcgtcaa 3207121 gatcaagatc ttcttcgact gctttcttcg cttttttctt tttcgccttg actgtcggct 3207181 gagtttcttc atcaagctga tcataaggat accagctgcg aagcccccac gtctggtcag 3207241 aaagcgccag gaagcggccg tcaatgttta aatctgtata aaattgagca atgcggtctc 3207301 caagctcttc ttttttcacg ccgagcaaag atgcgatttc atttaaaagc tcctgaaaag 3207361 gaactggttt tttatgttct tcaaataatt cgtgagcgat ttcaactaaa gccatttcct 3207421 ttagctcttc ctgtgaatat tgtttgatac ccaaggtcgg acactccctt tctattactt 3207481 atatgtatct gttttatcaa taatgaaagc gattttgtat cgttcttata caaaccatac 3207541 ctctcattat aaacaaaata aaacagaata tgctaccctt aacagcgtta atttaaataa 3207601 ttttacaaga gtgatccgac tgagagatgt tttccgttaa tccgcgagca ttctggagat 3207661 gaccagtctt tgaatttctt gagtgccttc atagatttgc gtgatttttg catcacgcat 3207721 atagcgttct accggataat cttttgtata gccgtagccg ccgaaaatct gcacggcttc 3207781 ggtcgttacc ttcatcgccg tatccccagc catcagtttg gacatggcgg aagcttttcc 3207841 atatggaagg cccgatgatt ctaaccatgc agcctgatag gtcagtagcc ttgaagcttc 3207901 tatcattgtc gccatatccg cgagtttaaa agcgatgccc tgctgctcgg cgatcgattt 3207961 tccgaattgc tttcgctctt ttgcatattg aagcgccgca tcaagcgctc cttgggcgat 3208021 gcctacagct tgtgcagcta tgccgtttct gcctccgtca agcgtcttca tcgcgatttt 3208081 gaagccttct ccttcttctc cgagacgctt tgatgcgggc actacacaat cttcgaacat 3208141 gatttccgtt gtcggtgaag aacggatgcc cagcttcttt tctttcttgc ctgtaaaaaa 3208201 tccttcaaaa tccttttcta ctataaaagc ggtaacgcct tttttctttt tctcgggatc 3208261 ggtgacggca aaaacaatgt aaatatcagc aacgccgccg tttgtgataa acactttgga 3208321 accatttaac acatagtcat cgccgattcg ttcagcagtt gttttcatgc tgccggcgtc 3208381 agagccagac cctgcttcgg tcaaagcgaa tgcgccgatt ttctctccga gagccagctg 3208441 tgttaagtac tctgtcttct gttcctctgt cccaaaggca aacagcggcc agctgcaaag 3208501 agagatatgg gcggaaagcg tcacaccggt ggaggcgcac acttttgaca gctcttccac 3208561 cgcgatgacg taggctaaat agtcacttcc aattccgccg taatcttcag gccatggaat 3208621 tcccgtcagg cccagatttg ccatttcccg aaacagctcg cgatcgaagc gttcttgttc 3208681 gtcccgttca gccgctgtcg gggccacctc atgcttcgca aaatcgcgca ccaattttcg 3208741 tatcatctca tgttcttctg ataatgaaaa attcattgct tctcccccat tttcagatca 3208801 gcgcctaaaa cggattgagc cagaagctcg acgacgtcgt acgttttgac ttggtcttcg 3208861 gcttccttcg cctttgtgcc gtccccaagc atcgtgagac aatacggaca gccagaactg 3208921 atcaccgatg ggttgactgc gagcgcttgc tctgtcctgg cgacgttaat cctgttgcct 3208981 gtttcttcct ccatccacat taatcccccg ccggctccgc agcacatgcc ggtttcccgg 3209041 cttctctcca tttcaacaag ctgcacgccc ggaatggctt tcaaaatctc tctcggcgga 3209101 tcatagactt cattgtaccg gcccaaatag cacgaatcat ggaaggtaat cgtctcatga 3209161 agcgggtgct gcggtcttaa ttttccgttt ttcacaagct cggccagcac ttctgtatga 3209221 tgataaacct cgccttcaaa tccgaaatcc ggatattcgt ttttaaataa attgtatgca 3209281 tggggatcga tcgtaacgat ttttttgaca tcattttttt caaattcaga aatattcttc 3209341 tcagccagct cttggaacaa aaattcattt ccgaggcggc gcggcgtgtc tcctgaattt 3209401 ttttctttat tgccgagaat cgcgaaggac acgcccgcgt gattgagcag cttggcaaag 3209461 gaaattgcga ttttctggct tctgttgtcg taagacccca tggagcctac ccagaaaagg 3209521 tactcaaatt cttttccttc ttttttcatt tcttttacag tcggaatctc agcatccggc 3209581 gcctcgtcac gccaattttc acgttccttg cggttgagtc cccacggatt cccttgccgc 3209641 tcaatacttg tcattgcgcg ctgggcgtca ctgtccattt ttccttctgt cagtacgagg 3209701 tagcggcgga ggtcgatgat tttatccacg tgctcattca tgaccgggca ttgatcctca 3209761 cagttccggc aagtggtgca tgcccaaatt tcttcctctg tgatgacgtc gccgatcaag 3209821 cttggattgt aatcaagcgc cgctgcggct tcctgcgatc cgctgcccgc tgacgccgca 3209881 gccagctgat tgcctctcgt atgccgaaac gctgctgcgg gcacccatgg ggagcgcgag 3209941 gtgacggcag cgcctttttc cgtgagatgg tctctgagac gcaaaatcaa gtccatcgga 3210001 gaaagcattt ttccggtgcc tgttgcagga cacatattgg tacagcggcc gcactcgaca 3210061 cacgcgtata gatcaagcag ctgagactgt ctgaaatcct caatttttcc cgctccgtag 3210121 ctttctttcg tttcgtcggt aaaatcaatt ttttcaagtt ttccggcaga ttccattcga 3210181 ttgaaaaaga cgtttgccgg gccggcgatt aaatgggcat gctttgactg aggcacgtac 3210241 actaaaaagc taagcaagaa taggagatgg atccaccatg cgatatagaa aatcaccgcc 3210301 gcgcctgttt tcccgacacc gctaagcata aacgcaatac ctgaggcaat tggctcgctc 3210361 caagaaagcc catgctcatg ccaaatcaga ttcatcccgt tcccaagcag aacggtcagc 3210421 attaatcctc cgataaaaat gagaacgagt ccggctttga aaccgcgttt cagcctcacg 3210481 agcttttcga tataacgtct gtagaatgcc cacccaacag caattaaaat gagaaacgta 3210541 acaatttcct gaaaaaaggt gaaggcggga tagaccgggc caagcgacag attccggccg 3210601 ggagccagtc ctttgatgat aaagtcaatt gctccgaact gaaccaatat aaatccgtag 3210661 aaaaacatga cgtgaatgat tccgcttttc ttgtccttga gcagtttttt ctgtccgaat 3210721 acattcaccc atatggcgtg aagccgttcc ttgaaccgtt gatcaaattg ttctttctgg 3210781 ccgagcttga tgtaggccag tctcgttttg accaagtaaa caaacaaata gacagcgtaa 3210841 gcggttacaa tcagaaataa taatgcattt gcgatgagaa agccgctcat tccaattccc 3210901 cctttttact gataaagacc gcgatcccct acccccgaat ctgtataaga ttatctttat 3210961 gataaataat gaatgagtgt tcagtcaata attaaattcc tgctgttcgg gcacactacc 3211021 tttactacgg aaaggagtgc cggtatgaag gtatttatcg tgattatgat cattgtcgtt 3211081 attttctttg ccttgattct gcttgatatc ttcatgggcc gtgccggata cagaaaaaag 3211141 gcgtacgagc ctgttttttc aaaaaagaag agtgacatcg aattgatcca ctgcggcgct 3211201 gatctcgttg agcggatgat gaatgatatt cgccaggccg cctcttctgt tcacatgatg 3211261 ttttttatta tgaaaaatga tgaggtcagc cacaatatgt ataccttgct gaaaacaaaa 3211321 gcccaagctg gcgtatccgt ttatttgctt ctggattggg cgggctgccg ggcaattaaa 3211381 aaaacggcgc ttcagacgat gaaaaatgcc ggcgtccatg tccatgtgat gaatcgtccc 3211441 cgttttcctt ttttcttttt tcacatgcaa aaacggaatc accggaagat tacggtgata 3211501 gacggaaaaa tcggttatat cggcgggttt aatatcgccg aagaatatct tggaaagaag 3211561 gcgaagttcg gcaattggga ggattatcat ctgcgcatga tcggagaagg cgtacatgat 3211621 cttcaaacgc tttttgcttc tgatctaaaa cgaaataccg gaatcgaact gggttcggat 3211681 gtttggccaa agcttcagca agggactatt tctcacaaga tctatgcgac cgacggttat 3211741 tcccttgaaa acatatactt ggccaacatt gcccaagcga agaatcgcct tacggtttgc 3211801 acgccttatt acattccatc aaaaccgctt caagaggccc ttattaacgc aagaaaaaac 3211861 ggcgtatccg tgagaatcat tgtaccgatg aaatcagacc atccgctggt acgagaagcg 3211921 gcttttacgt attattcgga gctcttggat gccggctgtc ttatttatcg ttattatcaa 3211981 gggttttatc atgtaaaagc cctcatcata gacgaccatc tcagcattat cggaacagcc 3212041 aacttcgata aacggagcct gttcttaaat gaagaggtga atgttgaaat tgatgacgaa 3212101 gcgtttacaa gtgaagtcta tgccacaatt gaggaggata tgaaaaagtc ggagctgctg 3212161 acgatggagg atttcagcaa gcgcacattc aggcagcgcc cggcggaatg gctcggcagg 3212221 gcattatctt atttcttata aaggagagtt cctatgattt tcagattcgg gttcgtttca 3212281 aatgcgatga gcctttggga tgcgtctccc gctaaaacat tgacattcgc gcgttattca 3212341 aagctttcaa agactgaaag aaaagaagcg cttctgactg tgacaaaagc caatttgcgc 3212401 aatacgatga gaacccttca ctatatcatc ggccacggca ttcctttgta ccgtttttcc 3212461 agttcgattg tgccgctggc tacgcatccc gacgtgatgt gggattttgt aacaccgttt 3212521 caaaaagagt ttcgggagat tggagagctt gttaaaaccc atcaactgcg aacaagcttt 3212581 catccaaatc aattcactct gtttacgagc ccgaaggaat ccgtcacaaa aaatgcggta 3212641 acagatatgg cgtatcacta ccgcatgctt gaggccatgg gcattgctga tcgctccgtt 3212701 atcaacattc atattggcgg cgcttacgga aataaagaca ccgccactgc acaatttcat 3212761 caaaatataa aacagctgcc gcaggagatc aaagagcgga tgacacttga aaatgatgat 3212821 aaaacatata caacggaaga aacgcttcag gtctgtgagc aggaggatgt tccgtttgtc 3212881 tttgactttc atcattttta cgccaatcca gacgatcacg ccgacctgaa tgtagcactg 3212941 ccccgcatga tcaaaacgtg ggagcggatc ggccttcagc caaaggttca cttgtcttcc 3213001 ccaaaatcgg agcaagcgat acgcagccac gccgattatg ttgacgccaa ctttttgctg 3213061 ccactgttgg aacgctttag gcaatgggga actaatattg atttcatgat tgaagcaaag 3213121 cagaaagaca aggcgcttct ccgcttgatg gatgaattaa gctccatccg cggtgtcaaa 3213181 cgcatcgggg gcggtgcgct gcaatggaag tcataaatgt gcaaaaatag gtttacgact 3213241 tgtcagcttt gggaacttag gctatataag acaacaatcg atggaggaga aagatcatga 3213301 aaaatatcaa gtctctgaaa gtagccgcac aggcctttac tttaagaaat ttgattcatc 3213361 tttataaaat gtgccattcc ggaagccacg aggtttatat ttattcaaag aaaacgatgt 3213421 gcaaaatcaa aagcttaatt gagcttgaaa cgttccgcat ggctcataat gaaaaggaat 3213481 atctgatcgt agttgaagga acaaaagcat cacagctcat tgaaaaattc caaaatctca 3213541 tcgagcctgc tgagagagaa gcgctctaac ttacatacaa aaaaggatag acatctgtct 3213601 atcctttttc ttatgctctt acataatgga gctgaaccgc ttgtccaaat tgttttgtcc 3213661 cttttaaccg cagttttgtt tcatttgtta gttcgtgaaa cagcgggatg ccgcttccta 3213721 aaacgacggg aataacagtg atgatgaatt cgtcgatggc atcttctttc ataaagtcat 3213781 tcacaagctc tgccccgcca gctatccaga tgtttgagcc tttttcctgt ttcaaacggg 3213841 cagtgaaggc tctggctccc tcattgataa acgtcacatg ttcatcttga taactgtcgg 3213901 gcgatcctgt aaaaacatag caggttttat cctgatacgg gaaaaccggt gttagcactt 3213961 taacgtgctc atatgtgctc cgccctaaaa tgactgtatc aacagtctga taaaaatcac 3214021 tgtagccgtt gtcaccttca ccttcaaatt catccagcca atcgatgctt ccatcttctt 3214081 ttgcgatcat cccgtccaat gaaacagcaa tgtacagcac agtttttctt tccatgttct 3214141 cctcctatcg atgcaccatt tgcccgaatt gcgcttgatg cagcctgctg tataggcctc 3214201 cggcttcgat caggtcttga tgacggcctt gttcttcaat accgttgttt gtgacgacta 3214261 caattctgtc cgcgtctttg attgttgcca gcctgtgggc gatgacaagc gtcgtgcgcc 3214321 cctcagacaa ctcttgaagc gccttttgga tcgccgcttc cgtctctgta tcaagggctg 3214381 aggtggcttc gtcgagaatc aagatcgacg gatttttcaa gaacatcctt gcaattgaca 3214441 gacgctgttt ttgcccgccg gaaagcttca cgccgcgttc gccaatcata gtatccaacc 3214501 catcgggcat gttatggacg agctcttcca gatgcgcctg cttcacagct tgccaaatgt 3214561 cttcttctga tgcgcctagt cggccgtagg cgatattttc tctaagcgtg cccgagaata 3214621 agaaaacgtc ctgctgcacg acgccaatct gcccgcgcaa cgaagaaagc gtcatgtctt 3214681 ttatactgat gccgtcaatc gtaatgtcgc cctccgatgc ttcataaaaa cgcggaagca 3214741 gactgcaaag cgttgatttc ccagcacctg acggaccgac gaacgccacc gtttcccccg 3214801 cttgaatgga taggttgatg tcattgagga cattgtgatg gtcatcatag ccaaacgaaa 3214861 catgtttata gcggatattg cccttcaggc cggaaacatc tttcgaatca ggtgagtcct 3214921 gaatatccgg ctctgtctcc atgagctcca tatagctttt gaaacccgcg atccccctcg 3214981 gatacatttc gataatggca ttaattttgt caataggcct gaacagcaca ttcgtcaaga 3215041 gtacaaacgc cacaaattcc ccgtacgata aggagccgcg aatgacaaac cacgtcccgc 3215101 acaaaaggac aaacagcgtg acaaaccggg tcagcatata gctgattgaa ccgtttttcg 3215161 ccatgatttt gtaggaagaa agctttgtga cacgaaaacg ctggttgttg acggcgaagc 3215221 gttctttttc aaatgcttca tttccgaacg cctgcacaag ccggatgccg ccgatgttat 3215281 tttctacacg cgcgctgaag tctccgatat ccttgttcag cgtggtaaat gctttggtca 3215341 tttttttgtt gaaataaagc gctagccaaa tgacgatcgg cataatgata aacgttaata 3215401 aagcaagctg ccagttaata aacagcatca ctccgaacgc cccgagaatg gtcatgaccg 3215461 caatgaataa gtcttccggt ccgtgatggg cgacttcacc gatatacatt aaatcgttcg 3215521 tgagcttcga catcagcgtt cccgtcttgt tgttgtcgta aaatttgaac gagagctttt 3215581 gcaaatggtc aaaaagcgac tttctcatat cagtctcaat attgatacca agcatgtgtc 3215641 cccagtaggt cacgatatac tgaagagccg agctgagcgc gtacaccgca aataacccga 3215701 ttgaggtcgc gatgatcagt ccccagtccc tgcccggcag caaggtatca ataaaataat 3215761 tgacgatcaa aggaaaactc agctccatta aacctcccgc gatcgctgag aaaaagtcga 3215821 gaaagaacaa cgttttatat ggtttataat atgaaaaaaa ttgccgcagc accctatctt 3215881 cccccaatgt ataaataact gataatattt ctcaattata ctatacacgg gctgttttgt 3215941 aagatcagat ttcttttttc ttacagaaca cctgaaaaca ggcgggcaaa cgactctttt 3216001 gtccggtcag ccacacctct tttataaaag ccgacagggc tgagcttttc actttcctgc 3216061 atatcctctt caaaatgggc ctcaagggtt cggatcgctt cggcatccgt gaagaacaca 3216121 ttcacttcaa agttgagctg aaagctgcgc atgtccatat tcgcggtacc gacggaggcg 3216181 agatcgccat caatgatcat gactttttga tgcatgaagc ctttttggta ggagtacact 3216241 tcaatgccct caaggagcag ctccgggaaa taggacctcg acgcgtattg ggtcaaaaag 3216301 ctgtcgttct tctccggcac cataaccctt acctctaccc cctttgtcgc cgctgctttt 3216361 agcgccgtgc gaatggattc attggggaca aaatagggcg tggcgatcca tattgatttc 3216421 tgcgctgaag aaatcatttc ataataaagg tcgctcatgc tttccttcat gtcagggcct 3216481 gtcgcgacaa tttgataaat gcctcctcct tccacgggaa ccggggtatt gtactcctct 3216541 tgatcaatta gcacttcatt ggagacatat tcccaatcca gcataaagat agcgtggagc 3216601 gtttgcacaa tttccccctc aagccgcagg tgtgtatctc tccaaaatcc gatgtacgga 3216661 tctctgctga tatattcctt cccgacattt aatccaccca caaaaccggt tttcccatcg 3216721 atgatcacga ttttccggtg atttctgaaa ttcagcttct ggttgaaaaa cccgtatttc 3216781 agcggagaaa acgggacgat gtccaccccc gcttgtttca ttctcataat atctcttctt 3216841 gccagcttca tgcttcctgc cgcatcgtat aaaaacctca cctcgacacc ctggcgcgct 3216901 ttctccatca taatatccat catgccgcgt ccgagcatgt ctgatttaaa catgtagtat 3216961 tcaatatgta tgtaagattc cgcttttctc attgctttga aaatgtccgg gaaggtttct 3217021 tcgccgtttt tcagcacttt gatgttgctt ttcgtattga tattcatatg ggcagccctg 3217081 atggaatatg taaagaacct ctcttgattg tccttcagcc ctgtcacttc gggcgtttcc 3217141 tccttgtcaa acagcttcct gagcttttcc ctgttgtaca ttcgttttgt cttaaacagc 3217201 tttcccttta cataaagctg tcccgaaaac agataaaaca cgtagccgac gattggaaaa 3217261 aagacaagaa tatggatcca tagcagcgtg tgctgcgagg tgcggttttc aagaattaat 3217321 gaatagatgc tgaacaaaat aatgcttata tagcaaagca atcctccgta aaactcaagt 3217381 ctggaaaccg gaaaaaacca aatgacatat gccccgatga gcatcatata taaaaagaaa 3217441 aattccagtc tccttttcag catcctgatt ctctccaatc tgattcaatt acctctgtat 3217501 tacctctttt ttctaatcga taaaccttgt aagtaaaaaa cctctccgcc aaaggaggag 3217561 aggtttagag aaaactaact gtcacggaat tcatccgcat cgtttctgca gaaataaagc 3217621 aagactattg gcaacgccga gtgacaacat gagcggcaag ctgaacccgc tcagcactcc 3217681 ggcaagcgcc gaaaagaagg cggcgctgtg actgcaaata cggtggatag agtaaatttg 3217741 atacccattc tgatgagaga aaatatataa aacgggaaat tgatcagaaa gatataagga 3217801 gttagtcagg ctgaatcata atctggctgt tccgccggtt taaaatgagt aaaatccttg 3217861 atgttatttc catatacaaa cataacagga ttcccggcag cccagccatt accttggcag 3217921 aaaaaacccc ctcttgcaag ggggattttc acgagcgttt ccgatataca acgtagctgc 3217981 gggtcagata cttgagcggc agactgaaca catgaaccaa tctcgtaaac ggccacagga 3218041 taaaaacgac gtatcctatc acaatatgaa acttaaacca tagcgggaca ctctccatca 3218101 aagaggcgtc aggcctgaac aaaacgattt ccctgaacca gggcccgact gtggtccggt 3218161 aatcaaatcc tttcgaatca atgttgagaa acgtggccgc aacgcctgac agcatcatga 3218221 acagcagcag gaggagcgta aggatatcgg atggcgagct cgttttgcgg attcttttgt 3218281 caaacagcct tctgtacgtc aggatgacaa gtccggtaca tgccgcaatg cccgccggca 3218341 agccagcgcc aatcgccatt ttgtgataca tatgctctga aatgccaagg gaagcataca 3218401 cgccttctgg gatcagaatc cccatgacat gcccgccgac aacgcacagc agtccccagt 3218461 gaaaaagtgt gctgccagcc gcaagttttt tcttttctaa cagctcgctt gatttcgccg 3218521 tccagccaaa ttggtcatgc tgatagcggt aaatatggcc gccgataaag attgtcaata 3218581 caatgtatgg cataataccc cagaggatct gcccgctcat gcctgaacag ccccttcaac 3218641 gctttcacgt acgccaatgt tttcaagcgc ggccagcagc acgtgcagca gttcagcgta 3218701 tatactgtca tttttttcga gacgggatgc cagctccctc acattggaca gatatttctc 3218761 aaacacgctt ctcgctgctt caatttctgc agccgcagca aattccagca tcagcggcag 3218821 ataatcaggc agctctttct ctgtcggcag gaaaccggat tgctcgtatg tgttttttaa 3218881 atgcagcaat tcaatgccgc gttccctttg ctcgcctgag ttaaagtagg tgacatacat 3218941 atttgttttt ttcccgaagt cgaatgtata gacatagtgt tcaatcagcg cttccggaga 3219001 atagctggct gacgtctcga aaaagtgcag cagcttctcc cggatttgcc ggttgccgat 3219061 ttcttggata agagccttcc aatcgggaag ctcggctctc cactcttcat ccggataaga 3219121 gagaagacag gaaagagcag agaacgtgat ttgccggtct gtggtgttca tcttgttaca 3219181 cctcatttat caaaagttag aaacaggagc cggggccgcc tgaaaatgat aagccgcagc 3219241 ttccttgttc agcgtataaa tctgatactt cttctcgatg gctgctcgga atcacaaagc 3219301 ggtcatcata tttggcaatc gcaagcagcc gatacatatc ttcaatttgc tgttctgtta 3219361 agccgacact ggagatcagt tccggatcga ttgatttatt cgtctggacc gctctcatat 3219421 actggcgcat gacagacatt ttctttaatg ttgaccgaat atgatccgta tcaccggctg 3219481 ttaacagctg cgccaaataa tctatcggga ttctcatttg gtcgatagcc ggaaaaatat 3219541 cttccgccgt ttgccggctg ccttttcctt caaagagatt cataatcggg ctgagcggcg 3219601 gaatgtacca caccattggc agcgtgcggt actcaggatg aagcggcagc gcgatcttcc 3219661 agtcaatgat cattttatag atcggtgatt gctgcgcggc ctctatccat tcagccggaa 3219721 tgccttgttc ttttgccagt ttggcaacct caggatcatt cggatcaaga aaaacgtcca 3219781 attgggaatg gtagagatcc ttttcatttt caacagatgc cgcttcctcc actttgtccg 3219841 cgtcatatag catgacgccg aggtagcgga ttctgccaac acacgtctca gagcagatgg 3219901 ttggcagtcc cgcctccaaa cgcggaaagc agagtgtgca tttttccgct ttgttcgttt 3219961 gccagttaaa atagactttt ttataaggac aggatgagac gcaatatctc catgaacggc 3220021 atgcgttttg atccacaagc acaatgccgt cctcctcgcg tttgtacatg gcgccggatg 3220081 gacaggatga gacgcatgcc gggttgatgc agtgctcgca aatacggggc aaatacatca 3220141 taaagacgtc atcgaattct gttttgatcg attcctccat cttttgtacg ttgggatctt 3220201 caagtcccgt aatgtggccg cctgcgagat cgtcctccca gttcggtccc cattcgatat 3220261 tcatgaaatc ccccgtcaag gacgatttcg ggcgtgctac cggctggtgt tttttctgcg 3220321 ggctgttcgt taatgtttca taatcatagt tccaaggttc atagtaatca tcaattgacg 3220381 gctgattcgg attatagaaa aggcctgcaa gccgattggt tttcgagccc gatttcagct 3220441 cgagctttcc ttttttcaat gtccagccgc ctttatattt gtcctggtcc tcccattgct 3220501 tcgggtagcc gatgcccggc tttgtttcta cattattgaa gtacatatat tccgcaccgg 3220561 aacggtttgt ccacgtgttt ttgcaggtga cgctgcacgt gtggcagccg atgcatttat 3220621 ccaagttcat gaccataccg atttgcgctt taatcttcaa gccaatcgac ctccttcagc 3220681 ttgcggatga cgacgttcag gtcgcgctga ttccccgttg gaccgtaata attaaagccg 3220741 tagctgagct gggcgtagcc accgatcatc tgtgtcggct tgacgtgaat ccttgtcggg 3220801 ctgttatggg tgcctccgcg gttattcgtc agctttgtgc cgggcacgtt gatgtggcgg 3220861 tcctgggcat ggtgcataaa cgccattcct ttaggaatcc gatgagacaa aacggctctc 3220921 gcgacgacaa cgccgtttcg gttgaagcat tcaatccaat cgttgtcttt gatatccgtg 3220981 tcctctgcat catctttatt catccacacg gtcggcccgc cgcggaacag cgtcagcatc 3221041 ggcagagaat caaaatacat gctgtggaca gaccatttat tatgcggcgt caaataattg 3221101 aggacgattt cttttccctc ttgatcaggc cgtttgctca gaaacgggcg atgctggagg 3221161 atcggtttga atgtcgccat cgtttcaccg aattccatca tcagttcatg atcgacataa 3221221 taggattgtc tgcctgtcag cgtccgccac ggaattaatt tttcaacatt cgttgtaaac 3221281 ggcgaatacc tgcgccctcc tttttcagag ccggtaaacg ctggagacgt gatcaccgtt 3221341 ttcggctggg ctgtaatttg ttcgaacgta aagcattctt cctcgcgttc ttccgccagg 3221401 tctttcagct tcaggttcgt gatgttttca agtgattccc atgcttttac tgcgaccttt 3221461 ccattcgaag tggatgatag ggttaaaatc gcttctgcag cctgctttgc ttcacttata 3221521 tttggacatc cctttgccac gctgtccgag gtgatttctc ccagtctctg tttgagtgat 3221581 tcatattcat cggctattga ccagctcatc ccttttgttc cgctcggctt taaagcaacg 3221641 ttcggaccaa gtgcagtcat tttatgaaaa atgtgtttgt aatcccgttc aacgacttgg 3221701 atgttcggca tcgtttttcc cggaatggct tcacattcgc ctttgctcca gtcattgatt 3221761 ttgccgaatg gctgggccaa ttcctgcatg gtgtcgtgga gcagcggtgt cgcaaccact 3221821 tctttcaccg gctccatatc gacttcttct gccagatcgg aaacggcttt tgacagcgcc 3221881 ttgaaaatat cccagtctga cttcgattcc cacggagccg agatcgcagg agcaaatgga 3221941 tgaatgaacg gatgcatatc tgtgctgctg agatcgtgtt tttcatacca tgtcgccgcc 3222001 ggcagcacga tatcggaata cagcgccgta cccgccattc gaaaatcaag attgattaat 3222061 aagtcgagct ttccttccgg cgcctgctcc cgccatttga tttcttctgg gcggatgctg 3222121 tcgctgtcgt cattcattaa accgttcgtt gtccccagca aatgcttgag aaaatattca 3222181 tgcccttttc ctgagcttga gatcagattt gcccgccata caaagagatt ccttgggaaa 3222241 ttcacttcat tgtcaggatc ttcaatcgcg aatttcagtt ttttctcttg gagctgtgag 3222301 gccacgtacg cacctacgtc ttcaggtgtt gctgcccctg ctttttcagc ttctttatac 3222361 agatcgatgc cattttgatt gaaagtcggg taagacggaa gccaccctag ccgcgccgcc 3222421 agcacattgt aatcagcgtg gtgcttgtag cgggatgaag cagcaatcgg tgatgccaaa 3222481 tcactgatcg gctggtcctc ataacgccac tgatctgtcg caaagtagaa aaatgaggtg 3222541 ccattttgca gcttgggcac gccttcccag tcctttgcag ttgcaatcgt ctgccaccct 3222601 tcagcaggtc ggagcttttc ctgccccacg taatgggccc agcctccgcc gtttacgcct 3222661 tgggcgccta caagtaaaac aagatttaac actgctcggt agatcgtgtc ggagttgaac 3222721 cagtggttaa tgccggcccc tacgataatc atggaccggc cgtctgtatc gatcgcattt 3222781 tgggcaaact ctctggcaat cttaacgaca gcttcttttt tgattcctgt catttgttcc 3222841 tgccaggcag gcgtaaacgg ctcagggtca tcataggaga cagccgatcg ttcgccgatg 3222901 ccccggttca cgccgtagtt agccagtatc aagtcaaaca cggtcgtgat gtacgtttct 3222961 tcaccgttca ggttcatttt tttaatagga agatcccgct cgagcacttt gtttccgtca 3223021 tttgaaaaat acgggatgcg caccgtgccg atttcgtcct ctattcccag cacagagaga 3223081 cggggttcaa tcggttcccc ggtttcttca tcaatcatgt gcaggttcca tttctgctgc 3223141 ccgtcccagc gcgagcccat tgtcccttgg ggtatggcaa atgaacttgt ctgttcatcc 3223201 caaaccgcag gcttccactg atcatgcttt gtcttccgcc cgatgtcctt cgcatgcaga 3223261 aaccgtcccg ctgtgtatac gccattttct tttgacagag tgacgagaaa tggaaaatca 3223321 gtgtattgct tcgcgtactc aataaaacgt tcagtttctt ggttcacgta aaattcctgc 3223381 agaataacgt gacccatcgc catcgcaagc gccccgtcag tcccttggcg aatactcagc 3223441 cagtcatccg cgaactttga ggattccgca aaatctggac tgatcgaaat gaccttagcg 3223501 cctttatagc gggcctccgc caaaaaatgc gcgtcaggcg ttctcgttaa cggaacgttg 3223561 gagccccatg tgataatata gccggaattg taccaatcac tgctttccgg aacgtccgtc 3223621 tggtcacccc aaatttgcgg ggatgctgga ggaagatccg cataccagtc ataaaaactg 3223681 agcatagggc ctccgattaa cgacataaac cgggagcctg atgcgtggct gatcatggac 3223741 atggccggaa tcggagaaaa accgacgttt cggtcaggcc cgtatttcat cactgtatac 3223801 agcagagagg ctgaaatcag cttcagcacc tccggccatt cagcgcgcac aaaaccgcct 3223861 ttccctctcg cctgtttata ggacttcgct ttttcagggt tttcgacgat cgatttccag 3223921 gcttccaatg gattttgatg cgtctgcaat gcctcccgcc acaaattgat cagcacaccg 3223981 cgcacgtatg gatatttcac acggagcggg ctgtagatat accatgaaaa actggccccc 3224041 cgcgggcagc ctctcggttc aaaatcaggc atatccgggc ctgttgatgg ataattcaaa 3224101 ttttgccctt cccacgtgac tattccgttt ttcacataaa tattccagct gcaagaccct 3224161 gtacagttga cgccgtgggt ggagcgaacg actttgtcgt actgccatct gtttctgtat 3224221 acattctccc aatcgcgatc ctcgcgggta gtttggctat gtttatttga atggtgttcg 3224281 ataggagaga aataattcaa tctcctaaac aacggactcc ttttcttttt cttcatgaga 3224341 gttcactcct tccgagtcag gtgatgctaa gttcactata aacagagaca gcgtgtttcc 3224401 ttgtgaacta tgtcacacac tctgcttttt tcacaaaatg ttcacacaaa ggagaaggaa 3224461 ggctgcgttc aggcaggacg cttgggtcat tagctgcctt tcattcaaag atcaaaaaaa 3224521 accggctcta tttaagaacc gggctcagcg ttttcatcct gtgatgtatg cagataccgc 3224581 aaaaataatt gataggaaca aaaaacattt tgctgaagca tagccaaaaa gttcatttgc 3224641 agctgcggat gataagacat cattttctta aatatgtaat atgggatgtt gagaatcaga 3224701 atgtctgaag tggcattgac tgagataaag ggcgataaat aaagcccgcc tttttcatca 3224761 atcggaaaca catcgccttt ttcccacagc gcaacggttt tcgacccttc agggagcctt 3224821 gtgtccataa aacggacact gccttttaat acaatataaa cagattgaga atgaagaaaa 3224881 gatggagact gatcacatga accgcggata aacgtgccgt ttttcagcaa ggtttcgaca 3224941 atggatagag gcacttcatt aaacatagga agttgtttca gaaataataa atagtcacac 3225001 tgattcatag gaaaacctcc tgtgctaagg atagctttag tgtagctcga ctgagcctgt 3225061 acagcagtga tgtatttcac agcctgtatg atgaatgtca cttatcagga gggtgaatgc 3225121 atttataatg aaagaaaaaa ggaggatttc gatgaaggcg ctgattccga agcagcacgg 3225181 ggcgtgggcg atgctgctga tcccattttt actcggcatg gtcaagggag gccccgttat 3225241 ttggcatatt ccgctcttcc ttggttggct tttcctatac ttagcggttt atcccgttac 3225301 gcttgcctta aaaaagaaac aaagcaaacc atatcaaaag tggatgtgtt attacggttt 3225361 tcccacctgc tgctttttga tgatctcggt ctttcataag ccgcctctca tctgggtggg 3225421 cgtttcttta ctgccgctgt ttctcataca tatgtatttt gcccgcagaa aaaacgaacg 3225481 agccttattg aatgatgttg caggtgtctt gttcttttgt tcgggcgggt ttgcgagctg 3225541 ctggctgggg atgggaaccc ttgacggctg ggcttggttt attttcttgc agtctgcttt 3225601 attttttatc gggagttcct tttatgtgaa atcggtgatc cgcgagagaa aaaacagggc 3225661 atttgcatac tggtcatggg gatatcacct gctgctcccc tttttatccg ctcttttcgg 3225721 agcaggatgg gcgtttctcg cttttatccc gagcagcttg cgggcatggt tttttcatgg 3225781 aagggattgg cccgtaaaaa cgattggcat tctggaaatc gtgaatgcct gcttctttct 3225841 tgccgtcatg tgcctgttta tcacaaggta aaaaaacaag gacaccgctg tccttgtttt 3225901 tttcagtcaa tattgcaaat ctccagcggg caattttcac actcaatctc acatcgtaaa 3225961 tagtcccgct tgtgcaaaat aatttttccg gattcgtcta tcgaaataac cccttttttg 3226021 cggagatctc cgagcatacg attgacgctt tcccgtgcag ccgcgcaaaa ctttgccaaa 3226081 tcctgatttg tcaggacaat gttaatcaga atgccgtcgc ttcgctccac tccgtagctg 3226141 tttgataagc ggataagggt agaatagagc gccccctttt tgccatgaag aagcagatcc 3226201 ctgattttgg actgaatctt ccggaggtgc gtgctcatcc atttcatgaa ctcaaatgtc 3226261 aaagcgccgt tttggattaa ttctttttcc agcttatttt tattaatgac gagcacctcg 3226321 ccatcctcta gtacttttgc actgagcata taccttggtt cttcagtgaa aagtgttaat 3226381 tctccgacga tatcatgctt ttggcagatt ctaagcgtca ggtcttttcc gtcagatgtc 3226441 agcttgccga tttcaatgag tcctgattga atcagataaa gctcttctgc atccattcct 3226501 tcccgaaaca aatacgtgtg tttttccatt tttcttttcg tgctgatcga ttccagcaat 3226561 tcatacagat cgctggatat aagatcacta tcagatggtc gaacagagag aaaattcatg 3226621 agctcacctc gaagaaagtc acgttgtgtg tttattgtaa cgtgaattga tttgtaccca 3226681 tcgagaaaaa actaacaatc ttgtgaatgc cccagtgtta gttgatgctc tggctgtttc 3226741 tctccgtgtg tgttttcatt ctttcctgcc aatacatcca tatgacaagg acaaaactgg 3226801 ctaacgccac ctctgaaagc gccataaacc cgatcgcgta ctggcctgtt gcctgaaata 3226861 cactcgccaa tatgagcgga ggaaaaaagc cgcctaaacc gcccatggca gacacaatcc 3226921 cattggcaat ccccgcttgc ttcgaaaaat agaaaggcac cagtttaaaa acagttccgt 3226981 ttcctatgcc tgagcagacg gccacggtta atgatccaaa cgtataaagg ccgattgtcg 3227041 gcgagaacga taggataatg cctgataatg taagcccggc aaaaacaaac atcaagatgc 3227101 ggagcgggct cattttatca gccaggaatc cgcccgcagg cctgagcagc gtagaaaccg 3227161 caataaagcc agccgtccgc aagccggcat ctgcaggatt cagcccaaaa tgctccacca 3227221 gaaagttcgg cagatagata gtgaaggcga caaaggcacc gaacgtaata aaataaaaca 3227281 ggctcagaaa ccatagcaca tgatttcggt aaacagcttt gatttgagtc ttaacagaaa 3227341 ctttgacctt cttctcatgc ctgtcgccaa acaatacgtg cagtaaggca aagacagcca 3227401 gcaaaatcag atacatttgc acggttgatt tccacccgac ggcttgagcg ataaccggcg 3227461 ctgcaaatgt cgtaacggct gtcccgatat ttcctgcacc gtaaatccca ttgacgacac 3227521 cgtgcttttc tttcggataa tatttcggga gggaggtcac cccaatggaa aacaccgctc 3227581 ccccgatccc taagaaaaag ccgcctgcga ttaaatcaaa cagagaatcc gcgatactga 3227641 tccaaaatac aggaaataaa agcaggatga agctgaccat aaacatgagc cgcgcgccaa 3227701 acctgttcgt taaataccct aaaggaatgc ggagaagcga cccgaggatc acaggaatcg 3227761 cggtcactaa agaaatctca cccttgctta aatgaatatc taatgtgatt tgggaaatga 3227821 gtgatgaaat cagcacccaa accataaacc ctgccaccaa gcttaatgac tgtaacgata 3227881 attgaatgtg ttgacggttg atcatttggc ttgccccttt caatgattca ataatcagtc 3227941 ttatcataca aaaactagcc aaacaggatt gtgaattaca tcacacgttt ttctcataaa 3228001 aaaaggacaa agcccgaaga ctttgtcctt ttgatcgtga ttacattttt tccggagccg 3228061 atacgccgat cagctgaagc gcattgttca gcgtaatttg cgttgccttc attaaagcca 3228121 ggcgcgcgcg gcttttctct tcattttcag ggtcgatgac tttctctgcg ttgtagaagc 3228181 tgtgcagagc agaagccaga tcataaatat agttagtgac acggtgcgga attcgttttt 3228241 ccgctgcttc cgccactgcc tctgggaagc cgccgatcgt tttcagcaga tcgtattctt 3228301 tttctgattg aatatggctg aaatcaagat ctgccgccgg tttaagcccc tgctcttccc 3228361 cttggcgaag catgctgcaa atacgggcat gcgcgtattg tgcataatac acagggtttt 3228421 cgttagatgt tgatacagca agatctaagt caaaatccat atgggtgtct gcacttcgca 3228481 ttgcaaagaa gtaacgcacg gcatccaagc cgacttcttc aatcaggtca cgcatcgtta 3228541 cggctttacc ggtccgtttg ctcattttca ttttctcgcc gtttttgtaa aggtgaacga 3228601 gctgaatgat ttctacttca agcgttcctt tttcatagcc cagcgcttcg attgccgctt 3228661 tcatacgcgg gatgtagccg tggtgatcgg cgccccaaac gttgatcagc ttatcaaagc 3228721 cgcggtcaag cttgtcctta tgatacgcga tatcaggaag aaggtacgtg tacgtgccgt 3228781 ccttcttgat caatacgcgg tctttatcat cgccgaaagt cgtggaacgg aaccaagtcg 3228841 cgccgtcttc ttcatagacg tggccttttt cgcggagcgc ttcaagcgcc ttgtcgattt 3228901 ttccattttg gtacagtgaa gtttctgaat accacacatc aaacggcaca cggaagtttt 3228961 ccaagtcctt gcgaagcttt tccagctcgt atttcaggcc gtattcacgg aaaaacgcga 3229021 ggcgttcact ttcctcttcg ttaacgaaac gatcaccgta ttcctcagcg agacgctttc 3229081 cgatcgcaat gatatcctca ccgcggtagc catcctccgg catcggtttt tccaatccga 3229141 gtgcttcaaa gtaacggact tcaacagaaa gcgccagatt gttgatttgg tttcccgcat 3229201 cgttaatgta gtattcgcgg cttacatcgt aacccgcttt tgaaagcacg ttgcacaagg 3229261 aatcgccgac agccgccccg cgcgcatgcc cgaggtgaag gtctcccgtc ggattcgctg 3229321 atacgaattc tacctgaact cgttcaccgt ttccgatgtt cgtttccccg tatgcttccc 3229381 ctgcttccag tacagacgga atcagctttg ttaaatattg attgttcata tagaaattga 3229441 taaaacccgg gccggcgata tccagttttt caatcgaagc cttcccttta tcaaaatggg 3229501 cgacaatctc ttcagcgatt tgacgcggcg ctttttttgc cactcttgcc aactgcatcg 3229561 ccatattcgt tgagtagtcg ccgtgtgttt tatctttcgg tgtttctaaa acaacattgg 3229621 gaatctggct ttcttcagcc agtcccgctt tcagaacggc cgctttgatt tcttctttca 3229681 gcacgtcctt catttgttcc gcaatgttca tgcgtgagtt cctccctcat acgtgatcgt 3229741 catattatgt aaatgctcct gctcgtctcc gacatgcatg tcatatgcga tgctgatacg 3229801 gcctttttct tcatcgagat cagattgaat cgattttgtg cttgttttca gctcaagctc 3229861 accaaatgac attttatatt tagcaattgt ggaagctccc gttacgaaac gctgattcat 3229921 tttgacagcg cctgacctca tgaccaggac ttcgccttcg cttactttca caatcgtttt 3229981 gactttgcct aagtcgtgtt cttcataata agatagatac actttatttt gttttacata 3230041 gtaaaatccg gtggtgcgga attcgatgac ttcttggttt ccgtcatcct cgatcacaga 3230101 cttcacatgg agtgttatcg gtgtctcttg cttcattctg acacgtcctt ttcatcattc 3230161 cactttgact tgaatagtat aatcattcgg tttgtaaact tcaactgctt ctatcttacc 3230221 atcattgctc atcagatttg aagataaacc tcataaaaag catttcctta tatagaagag 3230281 aaaatcatat cactaattac ctttaggaaa tgttacgagc tcgctacatc gcaatcgcag 3230341 acggacccgc gccaaccgga atcaccgtca cggctgtata atcacttgtg cggtacacgg 3230401 tcacagcatt gtcgttgggc tgtgccgcat aaatatactg tttgtccggc gttacggcga 3230461 ggtcaaaggc gccggggaga gacacgtttg caatgatcct ctgtctggcc gtattaacta 3230521 cgtataagtt attaatgaga aacggttcac tatatggctc tagaaaataa gctctagtac 3230581 tatcgagaga aaatacaatc gtcctcagcg tttcaaataa acggctgaag tcccctcccc 3230641 tgcttaatgg tgacaaacta atctccgtta cacctttcgg ccacagctca ccattcaata 3230701 cgtacgcaaa atttccagcg taaggagttg taattaaact gggaaattca aatgtatcta 3230761 tgatactttc taccaactgc ccagtattta catcatattt atcaaccgac caactgcttc 3230821 cattagcggt atagacatac tgtccattcg gatcaagagc aaagtctaaa gcgccgggta 3230881 tcggaatgac atcaatgacc gattgagagg ccgtgttaat cacatatata gatccggcgg 3230941 ccatcacgta tgcgaactca tctgttggat caaattcgat ttttctcggc cctcctccaa 3231001 cagtaatggt atttatgatg gttaatgttt tattatcaat cactgagaca aggttggtat 3231061 ttccatggag gacatacgtg aatgctttat cgaaagtaac gcctagatta gttggcacgt 3231121 cagaaaaagg gattgttttt acaacagtgt ttaaatctgc atcaataacc gaaaccgtgc 3231181 tgtctccagt attggcagta aacacatacg attgagggtc tggtgatggc ggtaaaacaa 3231241 gtgtcccggc caccgtaagc ggactgccgt agaaaggcgg tacaatgagc agatcttcca 3231301 ctgttatttg actgaaatca ggacagcggc cagactgtgc tgcataataa acaacttgat 3231361 caatctcttc agtatgaatc acagaaacag ccccgtctcc ttgtccatat tgatttcgta 3231421 caggcgacac actgacaaga agcgtaatgg tcccttgtac tctcacagca tatcgaacac 3231481 cgatatcttc tggttccggc ccagtctgga ttaagcaagg ctcactgata caggacaaat 3231541 tgtctgtact ccatgtaaca gccgctgacg cttcggccgt atcaaccttg aagccctcag 3231601 ggaaatctat cggcacttga aacggcgctt cccggctaat ttcctcatca caaaaacaga 3231661 aacaattttc ctgtaaagca gaaagatcat tctttttcat gatttcacgt ccttttagaa 3231721 atgcacaaca tgcagcggtt aaatcgtaat ggcacccggt gaaaccccaa gagatatcac 3231781 agtttcctca gaataatcat ctgtgttgta aacaatgatg ctctgctcta taaaacgagt 3231841 tgcatacaga aaatcgccat tcggggtaaa cgcatagtct gttgctgatt gcggaacatt 3231901 tcctataacg cctgctccat ttggactgac agaatataaa ttgccagtga agccgtcata 3231961 taaatacacc tctgctccac tcgtaaacat tcgatattcc ccttcatact ccagctcttg 3232021 ggtgctgctg atggtaaacg tatttaaatc aataaccgtc aaataattaa aaaagaattc 3232081 ttgttctaat acataggcat accgctccgg ccaatttgtt tctatggttg atacgataag 3232141 ctctcgttca attgttcctg tgacttcacc ggtagttagg tccacttttt gcactattcc 3232201 aaaattcaga acataggcga ataacccatt gggatcgatt gcaacatcat atccttccac 3232261 aggaatcgac ctatccacag ttaacgtatc aattccaatc acataaaccg cagtaccggt 3232321 gaaaacataa gcaaactcat gattagggat aaatctaatc aatcgaggcg gctgatccag 3232381 caatatagtt gctgtcactg ttaatgtgtc ataatcgatg acagaaatca cattattgtt 3232441 gggatgtaag acaaacacag cgcttttatc tggcgtaatt tcaatacctg ccggattgta 3232501 cggaagagca atcgttgtca caacagtatc ggtgtttgta tcaatcacag aaactgattg 3232561 atcatttgga ttcgctgtaa acgcgtagac gggttccggc tccggtacaa gcacaattgt 3232621 ccccgtcacc gataaaggac tgccgtaaaa cggcggaaca acaacaaggt tctcaatcgt 3232681 gatgtcactg atatccgggc aatcatccga ttcatcggaa taatagacga cttgatcgat 3232741 ttctgcattg tgaatgacgg aaacagcccc gtccccttgt ccatattgat ttcggacagg 3232801 tgagacactg acgagtagcg taacggttcc ctgcaggcgc actgcaaatt gaacaccgac 3232861 ctcatcaggc tcaggccccg tttgaattaa gcaacggtca ctgacacaag aaaggctgtc 3232921 tgcattccac gtcacgtttg caacagcttc agccggatca acgacaaacc cttcaggtaa 3232981 ttcaatcggt gcttgaaaca tggcttctcg gcttgcttct ccctcacaaa aacataagca 3233041 ctcttcttgt tctgctcctg ctttttcttt aaaggaaagc ttgttttttc tcattccttc 3233101 acttcctttt cagacataca ctgctcacgc agatataaca gaatatggaa gggtaacgtg 3233161 tttgcttgta caaattgctg agggtaaacg cttctttttg aaaatatatc tccaaacatg 3233221 cggtgtaacg aaagaaaaaa ttgcggtttt tttgcgcttc tcacaagaat gttgatgata 3233281 aaatatgaca tatatagaat tatgaaggga gggatttgca aacgtgacag gtgtcatatc 3233341 ttcttcttcc atcggagaaa agattaacga atggtatatg tacatacgcc gattcagcat 3233401 acccgatgca gaatatttgc gacgagaaat caagcaagag ctggatcaaa tggaagaaga 3233461 tcaagacctt catttgtact attcactgat ggagtttcgg cacaacctaa tgcttgagta 3233521 ccttgaaccg ttagaaaaaa tgaggattga ggaacagccg agactgtctg atctgctgct 3233581 tgagattgat aaaaaacagg ctcgtttaac tggtctgctt gagtactatt ttaacttctt 3233641 cagaggcatg tacgagctgg accagcggga atatctgtcg gctattaaat ttttcaaaaa 3233701 ggccgaaagc aagctgatat tcgttaagga tcggatagag aaagctgagt ttttctttaa 3233761 gatgtctgaa tcttattact atatgaaaca aacgtatttt tcaatggact atgcacggca 3233821 agcatatgaa atatacaaag aacatgaagc ttataatata agattgctgc agtgtcattc 3233881 tttatttgcc accaattttt tagatttaaa acagtatgag gatgccatct cacattttca 3233941 aaaagcttat tctatggcag aagctgaaaa gcagccccaa ttaatgggga gaactttgta 3234001 caatatcggg ctttgtaaaa acagccaaag ccaatatgag gatgccatac cttatttcaa 3234061 aagagcaata gctgtttttg aagaatcaaa tattcttcct tccttacctc aagcgtattt 3234121 tttaattaca cagatccatt ataaattagg aaaaatagat aaagctcatg aatatcatag 3234181 taagggaatg gcttattcac aaaaggccgg agatgtaata tatttatcag agtttgaatt 3234241 tttgaaatct ttatacttat caggcccgga tgaagaagca attcaaggat tttttgattt 3234301 tctcgaaagt aaaatgttgt atgctgatct tgaagatttc gctattgatg tggcaaaata 3234361 ttatcatgaa cgtaaaaatt ttcaaaaagc ttctgcttat tttttgaagg tggaacaagt 3234421 aaggcaactt attcaaggag gagtgagttt gtatgaaatt gaagtctaaa ctattactct 3234481 cttgtctggc tctaagcact gtgttcgtgg caacaactat tgcaaatgca cctacacacc 3234541 aaattgaagt tgcacaacga ggaatgattt aaccgccgtc catcggcggt tttttcgtcc 3234601 cctctttacc aaagtctccc aatccatgct atgatctttt caataatctt gaagagagtg 3234661 gaaatgcagc atgtctctaa aaagtgtgag aacccacttt actcaatgga atcgagaaaa 3234721 tgatgtgacg gagttcgaaa cgtcgagtgc gacagttgaa caggcagctg agacaatcgg 3234781 cgtaagcctg tctagaatcg ccaagtccct gtccttcaga ggggaaggag atcaggtgat 3234841 tctgattgtg gcagccggcg atgccaagat cgacaacaaa aagtccaggc aaacatttgg 3234901 ctttaaagca agaatgctct ctcctaatga ggtgctggag cagacaggcc atgaaattgg 3234961 aggagtttgc ccatttggat tggctcatga tcctgaggtt tatcttgatg tatcgctgaa 3235021 acggtttcag actgttttcc ccgcatgcgg cagcagaaac tccgctattg aattaacacc 3235081 gaaagaatta tccgaatttt ctttctcaaa agtgtggatt gatgtttgta aagactggga 3235141 ataaaaaaac atccagacat cgtctggatg tttacttatt tcacaaaccc aagcagcatt 3235201 tcacggatga ttttgctggc tgtgtttgcc gtttgctctg agtggtcgta taccggcgcg 3235261 acttccacta aatcagcgcc ctttacgttt acctctgaac gcgcaatttc atggaccgat 3235321 gcaagcagtt ctttagacgt gatgccgccg gcgtcaaccg ttcctgtacc cggtgcgtgt 3235381 gcagggtcta atacgtcaat gtcaattgtg acataaaccg gacggcccgc cagcttcgga 3235441 agcacctctt tcagcggttc aagcacttca aattttgaga tgtgcatgcc gttttccttc 3235501 gcccattcaa actcttcttt catgccggaa cggattccga atgaatacac attgtgcggt 3235561 ccgatcaatt ctgccgcctt acggatcggc gtggagtgag aaagcggttc tccctcataa 3235621 tcaacacgaa gatctgtatg tgcgtcaaaa tggataatcg caaggtctgg gtatttcttg 3235681 tacatcgctt taatgacagg ccatgacacg aggtgctccc cgcccatacc cattgggaac 3235741 ttcccttttt ctaaaatgct gtccacgtac tcttcaatca tatccaggct tcgctgcgga 3235801 tttccgaacg gcagcggaat gtcgccagcg tcaaagaagt tcaagtcagc cagatcgcgg 3235861 tctaaatatg ggctgtattc ctcaaggccg attgacacct cacggattct gcttggacca 3235921 aagcgtgagc ccgggcgata gctgactgtc cagtccatcg gcatgccgta aagaatggcg 3235981 tccgcctctt cccactcggg acggctcgcg ataaatactt ttcctgaata agcttcatca 3236041 aatctcatct ataataccct cgctttcctg taaaaaagcg caagattcgc tcctgcgcca 3236101 taccttcatt atttaatcag gtcactcaca aatttcggca gaacaaacgc cgctttatga 3236161 atatcttttg tgtaatattt cgtctcaata tcgaagaaac ggctgtcttc cactgcaagc 3236221 ggatcatatt ttttcgagcc aattgtaaat gtccacaaac cgcttggata tgtcggaatg 3236281 ttcgccgtat acagcttcgt aatcgggaag atttccttca cgtcgcgctg tacatttgtg 3236341 attaattccg gtgtaaacca tgggttgtcc gtctgcgcaa cgaaaatacc gtcttctttc 3236401 agcgcttttg cgattcctgc gtagaatcct tttgtaaaca ggtttacagc cggtccgact 3236461 ggttcagtcg aatctaccat gatgacgtca tattgatttt cagattttgc aatgtgcata 3236521 aatccgtcat ctacctgcac gtcaacgcgc ggatcatcca gtttgcctgc gatagaagga 3236581 aggaactttt tagagtattc gataaccttg ccgtcaatat ctacaagtgt cgcttttttc 3236641 acgcttgggt gcttcaggat ttctctgata acgccgccgt caccgccgcc gactacgaga 3236701 acgtgctccg gatttgggtg cgtgaataat gggacatgcg ccaccatttc gtgataaacg 3236761 aattcgtctt tttcagatgt catcaccatg ccgtccaaaa aaagcatgtt gccgaactct 3236821 tctgtttcca ccatttctaa atgctgaaac tccgtttgtt ctgtatgtaa cgtcttgtta 3236881 accttcatcg taatgccaaa gtttttcgtc tgcttctctg tgtaccaaag ttcgctcaat 3236941 tgtcatctcc ctttcgaggc tgtattcatt tattgtaagc gtcttatcag cttttattct 3237001 cggttgaaat ctcattttca cctaaggaaa aagtatagag gatggcgggg aaaaagtaaa 3237061 gatgcgtcct gttctgcgat gtttaaaaac gatctttttt tctcataata gtagaaacat 3237121 aaaaaaaggg ggaacccgtt gtggatgcaa tgacaaataa acggctgaga ctgacgctga 3237181 aaaccgttcg cgcctttatc tttttagggg cttttgcggc cttggcggca gctgctgtgt 3237241 ttatgactgt cattttgata gccaaatacc agggcgctcc ctcggtgcaa gtgccgcaat 3237301 ccacgatttt gtacgcgagt gacggctcaa agctcgggga aacgaactac ggcgaaaagc 3237361 gctattgggt ccccttaaag gacatgaatc cgacgatcgt aaaagcgaca gtggcgattg 3237421 aagaccagaa tttctacgat catcacggct ttgattataa acgcatggcc ggcgcggcgc 3237481 ttgctgacct gaaagcattt gccaaggttc agggtgcaag caccatcacc cagcaatatg 3237541 cgagaaactt ataccttgaa cacgacaaaa cgtggaaacg gaaatggaat gaggcgttct 3237601 acacgatccg tctggaacaa aactattcta aggacgagat attagaaggc tatttaaata 3237661 cgatttacta cggccacggc gcctacggca ttgaagcagc ttcccgcctg tatttcggca 3237721 agcatgccaa aaacctgacg gatgcggagg cggcgctttt ggcaggaatc ccgaaaggcc 3237781 cttccggcta ttcaccgtat gtcaatgaga cgaaggccaa ggaacgccag aaaacgattg 3237841 tgcggatgat ggaaaagcag cagatgatca gccaaaagaa agcggatgaa ttgatcaagg 3237901 aacctctttc ctatcagcct ttgaataaac aagtttccaa gagaaaggct ccttatttct 3237961 acgacaatgc gatgagagag ctggaaaaaa agctcggcat gacacgggag caaattgaaa 3238021 cgagcgggtt aaacgtctat acaacggtag ataaacggat gcagcgcatc gccgaggaga 3238081 ccattaccga aacggttaac gcgggctctg acattcaagt cgggttttca gccattgatc 3238141 cccgcaccgg aaacgttctc gcccttgtcg gcggcaggga ttatcaaaaa agcccgtttg 3238201 accggacgac acaggcgaag cgccagcctg cttcgacgat caagccgttg ctgtactata 3238261 aagcgattca gagcggattt acgccagtca ctttgatgaa aagcgaagaa accgagtttc 3238321 aaattgatgc aaagggagaa acctattctc caagcaacta taacggatac tatgccaaca 3238381 agccgattac gcttctgcag gcgctggcgc tttccgacaa tatttacgct gtgaaaacgc 3238441 atctttttct cggcacgaac aaacttgtaa agacggcaaa ggaattcggc attaccgccc 3238501 atcttcaagc actgccgtcc ctggcactcg gcaccgaacc cgtacgtccg attgagatgg 3238561 tcaacgccta tgccatgctc gcaaatggcg gaaagaaaat cgaaccgact tttatttcaa 3238621 gagtaacgga cgcagccggc cacgtgctgt acgaaaaccc gaatcagcat aaacaggtgc 3238681 ttgatgaaaa agccgctttt gtcacagcga gtatgatgac aggcatgttt gatatcgatt 3238741 taaatggata tacgtcggtt acggggcgaa cgatagccaa ccgcctgaca agaacgtatg 3238801 ccggaaaatc aggaaccacc agcgcagaca gctggatgat cggcttcaat ccgaagctgg 3238861 ccgccggtgt ttggaccggc tatgacaaaa acagcaccat cgactcggtc gaagaaaaaa 3238921 gctatgctaa aaccatttgg gcggacttca tggaggacgc gctcaaaggc gaaccggaaa 3238981 ccgcgttcaa gccgccaaaa ggcgtaaccg gtgtgtacat tgatccggaa acaggctact 3239041 catcaggtcc cggctgcgcc gctaagcatt acacatattt tgtgaaaggg acagaacccg 3239101 caaacgtgtg ctacggggca gaacccgcaa aacaaacaaa agaccggctt ccatccaaag 3239161 aaaagcccgc ttccgagaaa aagtggtggg acaaatggct ggggcgacat cattgaaaat 3239221 aacccggctc ctcggaggcc gggttattcg tatggttcct tcataatcga tggaagaatg 3239281 ttagacaatc gagctgaaca atcagttttg ggataaagtg gtgaatttct catttcttcg 3239341 gcgctggctt tcatctccca gtcgccgact catatccccc taaaaatgaa aaaccccgag 3239401 tcttgtttcg gctcgggatt ttccatgtcc tatttctgta tcaccagttt actcaatgtt 3239461 tacgaaaaat atctcaaata ctttaaaagt tcacaaaaaa ttcataaatt aattgttttc 3239521 tggaagcagg ctcgttttta actcatctga ggaacggtcc cataggccct gatcatgctt 3239581 tttcagaaat tcgcctagta cacgcttcga gctgtcgtcc attttatcaa cgatgatttt 3239641 ccgtttcatg gatttatcca tcagattcac atgctcaggc agtgacttgt agcctcttct 3239701 gatgcttctg tcgaccgtca tttcacaggc tgtcacacca gcgtaataag gcccctcttc 3239761 ttttctgtca atcgttaccc acacaagcca gtatggtttt ccgttcggca cttcttcttt 3239821 attcgggaga aatttaattc ctttttcaac ggtgctgcgg gcatgcatag cgccgatgtc 3239881 tacgaacgct tctttttcct ctacatcaac gaatacggga gaaatgttat caaggctgag 3239941 tgcccctacg ccaaaaccgc cgtgtccgtc tgtcggatca cttttgataa tattaaaccc 3240001 gattgatttt ttcttttttt cttccatgaa gttctacctc ctacaaaagc ggttgaaata 3240061 tcgctgaaaa cagctttaaa atcgaatctc ttcctgcatt gagcatcggc cacagcacgt 3240121 aagatcctag cggtgtcaca aacagcacca aaaatacgat aaagccgtag ctctccgcct 3240181 gcgtcatttt ggcacgcacg cccggcggaa cgagatcttc tataattcga tagccatcga 3240241 gcggaggaag cggcagcaga ttaaataaaa acaagacaag attcagctgt atccaaatag 3240301 aaaaaaactg atccagcccc gtgctgaacg ccgcaagcat ttccattccg tacgcatgca 3240361 tcaacactaa caaaaagaaa ccaataaacg caagaatcag gttactgacg ggcccggcta 3240421 tagatacgag cacaccagca agccggggtt tcttaaagaa acggcgattc acgggaatgg 3240481 ggcgcgccca cccgaatccg gccaccagaa tcaaaatggt tccgaacgga tcaaggtgtt 3240541 taatgggatt cagcgtcagt cttccttgtt ttttcgccgt atcgtcaccg aatttgtatg 3240601 cgacataagc gtgggcaagc tcgtgcatcg taaacgacac aattagcgtg atgacgaggt 3240661 atggcattaa agataacgga taatataaaa aacggtccaa gtgagatatc cctctttctc 3240721 aaaatgcaag aatttacttt attcagtata ctataagaag cctctttttc taaagagagg 3240781 aaacgagata aaggaggatt cagcacccat gccatacgta actgtcaaaa tgctcgaagg 3240841 ccgtacagac gagcaaaaac gcaatcttgt cgagaaagta acagaagccg taaaggaaac 3240901 aaccggtgct tctgaagaaa aaattgttgt ctttatagaa gaaatgagaa aagaccatta 3240961 tgccgtcgca ggcaaacgcc tgagcgatat ggaataatct ctataaagcc ggcgcttcgc 3241021 gcaccggctt ttattatccc tattgagcca gcttcgcaat aatcgccaag aacgtctttt 3241081 tctcttcggc tgttaaacgt tcaaacatgc catcaatcag ctgctggcgg ttttcgatca 3241141 tttgttcagc cgctccccgg cccgattcag aaagagtaat ccatacagtg cggcggtcat 3241201 tgttatttct ggatctctca ataaaccctt cctgctctaa atgattcaga gctgtggtcg 3241261 tggcagaggg agacagtgtg acctccttca aaatatcctt tatggtgcag ctcccatgtc 3241321 tgtatatgat ccgcagaata aaccctctta cattattcac gtgtttcgga acggtggctt 3241381 catctaattg cttcgtgctt ttcaaatact ttgtaagtgc gtgatccagc aaatttgctt 3241441 ccagtttgtc atggtccatg tcaatttccc catttcgaga tgcattcata acatacgaac 3241501 gatatgattt acttattatt ttactgattc cgaataggga aagtcaaaaa agcaaaatgt 3241561 gaattcacag cttttatcct acatgcctcg attttccacc tgtttcacaa gtttatcttt 3241621 aaaagtttgg aaaggaacgt gttcattctg ctgatgtccg aatcggcgga cgtttaccgc 3241681 attctcctgc tcctcatgat ctccaagcac cagcacgtac ggaatttttt gcacctgcga 3241741 ttctctgatt ttatagccga gcttctcatt gcgctcatca atgccggctc ttatccccgc 3241801 ctgcttcagc tccgcctgca cttttctgca atagtctaag tgaacgtgcg aaaccggtat 3241861 gatttgaacc tggatcggtg cgagccagac tggaaaagcc ccaccgtaat gctcgatcaa 3241921 aatgccgaag aaacggtcga ttgagccgaa aaccgctctg tggatgacaa cgggacgaac 3241981 cttctcattg agttcgttga tatatgttaa atcaaatttt tccggcattt gaaaatcaag 3242041 ctgaattgtc gcgcattggt ggctccgttt cagggcatct tttatatgga aatcaatttt 3242101 cggcccgtaa aacgccccat cgccttcatt gatctcataa gagaggccaa gctcctcaag 3242161 gacgcgtgct aaggcacgtt ccgacgcttc ccaaaggctg tcatcgccta atgaatcctc 3242221 cgggcgagtc gaaagctcaa cagaatactc gaaaccaaat gtccgatata cctcatcaat 3242281 cagccgaatc gcttctttga tctcactctc aatctgatcc tcccgaacga aaatatgggc 3242341 gtcatcctga cagaacgtcc gaacgcgaag cattccgttt aaagcgccgc tgtattcatg 3242401 gcggtgcacc tgtccgaatt ccgccatgcg aatcggcaga tcccgataag aatacaggct 3242461 gtttttaaag atgagcatgt ggccggggca attcatcggc ttcattgcga atcttgtatc 3242521 atccacttct gaaaagtaca tattgtcgcg ataatggtcc caatggcctg actgctccca 3242581 taaccgctga ttcatcataa acggcgtacg cacctcatcg tagccggcat ttgtttgcag 3242641 ctcacgcgag aagcgctcca gctcattgcg gacaatctgc cctttcggca aataaaacgg 3242701 catccccggc gcttcttcag aaaacataaa cagccctaac tgtttgccga gcttgcgatg 3242761 gtctcgtttt gccgcttctt ctagcatatg caggtgcgca tccaaatctt ttttcttttg 3242821 aaacgcaacc ccgtacaccc gctgcaggac ttcatttttg ctgtctccgc gccaataagc 3242881 gcctgatact cttgtcagtt tgaacgcctt gatcatccct gtagaaggaa gatgcggccc 3242941 tcggcacagg tcaacgaatt ccccttgctg gtacagtgtg atatcctccc cgcgcggaat 3243001 atcctttaaa atctcaagct tgagccgctc gtctttttgt gcaaacagct cttcagcttc 3243061 ttcgtaagaa acctctatac gtttgatttc aaggttctca tttattatgt ttttcatttc 3243121 tttttcgatg gcctctaagt ctcctgatgc caagcttttc cccagcttca tgtcatagta 3243181 gaagccgtct aaaatcacag gccctacccc caatgacact tcgccgtaca gccgttttac 3243241 tgcttgggcc agcacgtgcg ctgttgtgtg gcgaagcacc tgcaagcctt cttgtgaatc 3243301 gagtgtgaca atcgaaagct cagcatcctc ctccagcttg aaactgagat caacaagctt 3243361 gccgttgacc tgacctgcgg ccgccttctt ttgcagactg gaactgatcg aaccagccgc 3243421 ttctttgatt gtgatgcctt tcggatattc ctggatctgt ccgtccggaa gctgaatgtg 3243481 tacatgtttg ctcattttag aacactcctt attcattgtt gtatataaaa aaacacaccc 3243541 gtcccgcaga tagggacgag tgtgtgatta acccgtggtt ccacccaagt tcccgacaaa 3243601 tactatgttg tcggctcggt gctgtaacgc agcatagacg gcattggtta cttcagttcc 3243661 ccaatgctgc tccaaggcgg taaatgatat tcctaagctg ggaagctctc acctttcctt 3243721 ccctctctga aaaccgtaac tatcattcat gtccttttca tcgcatgtat tcaattcata 3243781 aaaaaacaca cccgtcccac agatagggac gagtgtgtga ttaacccgtg gttccaccca 3243841 agttcccgac aaatactatg ttgtcggctc ggtgctgtaa cgcagcatag acggcattgg 3243901 ttacttcagt tccccaatgc tgctccaagg cggtaaatga tattcctaag ctgggaagct 3243961 ctcacctttc cttccctctc tgaaaaccgt aactatcatt catgtccttt tcttcgcatg 3244021 tattcaattc aaataaaaaa acacacccat ccctctaaaa gggacgaatg tgttgatcat 3244081 ccgtggttcc acccaaattc ccgatcaatt acacatgatg atcggcttaa agatgctgta 3244141 acgcagcatg acggtatcag atacttgttt tccctgatac ggctcaaagg cggtaagctg 3244201 ctttccctgc gttaggaaga tctcagctgt ccttccctct ctggaaaccg taaaaagcat 3244261 ctcgtgtcct tatcagtgcc tgttgtttca ataatttttt atatcttact atatattccc 3244321 acaaagcgca atcagtgatt tacatttttt ctgacgcggc agtcccgtta tgggcagcca 3244381 gaaacagcca tacaagcaat gcagcgaggc tgtatgccgc tcccatcatc aaaaacgcaa 3244441 acccggcacc agcataccaa gtggcggaca gatgaatgat caccccggtt atcgctacgc 3244501 cgaccaaggc tccgatttgc cggtttgcat ttaacgccgc accggcgata ttcgtatgtc 3244561 tttgcccggc agcctgcatg atcacagttg tcatggcagg aactgtaata ccggtacaga 3244621 ggttcataac agacatcaac accgccagct gccaataagg aaaatccgga gaaatcagca 3244681 caaacaacag caatgcaatg atacagctga ccgccattga tacaaacata agctgaccgg 3244741 cttcaaaccg attcgccaga cgggcaaaca gcagattgcc gatcacgaag accgccatca 3244801 tcggcagcag ctccactcca gccataaagg aacttgcccc tcctgcttcc tgcaaaaaaa 3244861 ggctgagcat aaacatgccg ccaaaaaggg cgaaattcag caaaaacccg ataaattggg 3244921 cagctgagaa gcggccgttt ttgtataagg acgccggcag gatgggtgtt tttgcagaaa 3244981 tttcccgcag caaaaacagc acaaatgcca aaaccgctgc agtaaatgct acaagaatca 3245041 ctggcgagcg ccagcccgct gaaggcccct gtatcaaagc ataggaaaga aacccgagag 3245101 ccatcatgcc aagcagatgc ccgatgatgt tcacgcggct gcttttccca ggaacgcggc 3245161 tgaggattcg gtaagctgaa atgagcgcag cagcccctat tggcacattg atcagaaaaa 3245221 tactctgcca gcccgccaac tgtaccagca cgcccccgat aaaaggccca agggctgaag 3245281 cggcggaaac aagcgcggcc cacagtccaa acattctcgc ccgcgcccgc tcatcaaggt 3245341 aagaggcagc caaaaggctg agtgagcttg gcataaacaa agctgcccca attccctgta 3245401 tgagacgtcc ggcaatcagc atctgcccat ttatagatgc agcgcataga caggaggcca 3245461 taacaaaaac ggctagaccc aagatataga tcgtcttcga gccgaaacgg tcagccaagg 3245521 ctccgcccgc cagcagaagc gacgcaaaag taagaatgta cccgtccaca acccacgtta 3245581 cacctgaaag tgacattgaa agagtgtttt tcatatcagc catcgccaca ttcacaacgg 3245641 tcacatcaag agttgccatg aggaaaccaa gtgcgagcac gatcagcacg gatatgcctg 3245701 ttgatgatgt tgattcttgt atagacccgc tatttttcat tacaattgcc ctttcacttg 3245761 cttgattacc caatcatcta ttttttcaag atcatacaat tccccgactc tgtccataac 3245821 atgctgcaag gattcttctc tcataagatt ggaccattta tcctcgattt ccgccatgac 3245881 tgtctccagc acacagtgac tttcaccctc aaatacagat tgcagcaagc ctttcccctg 3245941 atacatcgaa cctctgcctt cgaccgcttg ataaacatca taaagcgtaa tgtcagccaa 3246001 aggcttcgtc agggtaaaac cgcccttcgt ccctggtaag gattctgcca aaccggcttg 3246061 aaccaatgtt ctcatcagct tcttcaagta agacggagac acgcgcaatc gctggcttat 3246121 agcctctgac gtcaaagaag cctgtaccgg cagccgtgac agtaacagca gcacagaaac 3246181 cgcctgctcc attcctgatt tcattttcat cctattcact cctgattcat tatggataac 3246241 tattatccat aatgaatctc ttagcagctt ttgtcaataa aaaaagcaaa agaaacggat 3246301 catttctttt gcttggtatg gttaacaaat ctgcttcagt tcctctatgt attgaagcgc 3246361 ttcgtcatat tcttcatttg tatatttttg cttgcttttg atggtaaaga ctttttcttt 3246421 cttttcctca tcctcaagcc cgtcaaagta aaggatcgtg gaaaccagct ctaaaaaccg 3246481 tgatgaacgg ctgtttacac tgtcgatata gcctttcata tccggcatgt ccagatcagc 3246541 atggtctaaa aatgcggagc ctgtctcagt cagcgaatac cggtattgaa agtagccgcc 3246601 ctttttttcc ttcacctcat gcagaaatcc aaggttgcac agctcttcaa tctggagcgt 3246661 cagttcctct gaatatggtc cgtaaaagtg aaaatcatat ttctcataga aaggaaactg 3246721 cattttcttg gcgatataaa tcattttctg cagcttcttt cgcccgatga tttctccaga 3246781 atccgagaac accttcatca gttttgcatg ttctttcaac aaattcccga catctccttt 3246841 ttccttcttt ccaatttcta tgtcagtccc agcagctgcc ggattttcat tttcgcttcc 3246901 ggatgtttag tgccgtcaca aatcaagtcc tttggatagt acagcttgtg gtccgtccgc 3246961 cgtttacctg agatggattc cacaatagcc gactgtctgg acagctcttt aatttggccg 3247021 ttttgcgtca agagatggat cggcagacgc tcctcttcct ctcctggtcg gtaaaaatcg 3247081 tatggcagat ctgatgaaga atcaacgacc aaataatagc tcggatcgat ccccgcctct 3247141 ttgaacaatg aagtcagctc aaaataagcc gacatttctt cattcggatt gaattcaacg 3247201 tattggaaaa gctggcggtt aatgaatctg cggcacaagt cggataaaat cgcgtcttct 3247261 tcatcctccc aggcctggaa gtaatacaaa ataatagatt catccagctt tacataatcc 3247321 tccagtgtca attttccttc aaaaatagaa tagaaatgaa ccggagcgtg agtgaagaca 3247381 tagccttcat cgtgcagctg cttcgccctg tgaagaatct tcgttaaaat gacctctgca 3247441 cttctagtca caggatggaa gtagacctgc cagtacattt ggtaacggct catgatatag 3247501 tcttcgacag cgtgcattcc gctttcttta atgacgatct gatcctcgcg cggccgcatc 3247561 acccgaagaa tccgctccat atcaaaatgg ccgtagctga cgcccgtata atatgcgtcg 3247621 cgctggaggt aatccatgcg gtctgcgtca atctgactcg aaatcaggct gaccacttgc 3247681 ttgtttttat atgttttggc aatgacttca gcaacatcct gagggaaacc cgggctcacc 3247741 tttctgagca cctgattaac ctccgtgtct cccaaaatga tacctcttgt aaaatcctcg 3247801 tggtcaaggt gaaagacctt ttcaaatgaa tgcgagaacg gcccgtgccc gaggtcatga 3247861 agcagcgccg cggccaaaca gagttcgcgc tcactgtcat cccattcagg gcggccttta 3247921 aagacgtcat caaccattct tctgacaatt tcatagacac cgagagaatg gttgaaccgg 3247981 ctgtgctcag ccccatggaa cgtcaaatag gtcgttccga gctgcttaat tctgcggaga 3248041 cgctgaaatt cacgggttcc gatcaaatcc catatcagct tgtcccgaac atgaacatag 3248101 cggtgcaccg gatctttaaa cactttttct tctgataatt ttccatttgg atacgccatc 3248161 gtcattccct ctttttttta gccgtgtttc tattatatcg actctattct ttgaaaacat 3248221 ccttgaattt gcccggcgat ttgttccatc ttcatgaaaa acacatcttg tgaagcaaaa 3248281 aagcctgacc tgagggccga ggctaagaaa aaatatgttt ttactttttt attttctttt 3248341 ttactttgtc aatcagctca tcctctgtcg gagctgacag cgggcgattg ttcacaaaag 3248401 caaatgattt tttccgtccg ggcccgcaat aagattggca tcctacctca acctttgcgt 3248461 ccgggtccac ttctttcaaa cgcggcagca atgttttgat attagtggct tggcaatcat 3248521 cacacactcg aaattcatta gccatgacgt acgcttccct tcatttctat gttcatctat 3248581 gtgaataacc taaaatcacg tttcaaaaaa aatcacatca cacttcattt tacaaggatt 3248641 cgactgttcc tgcaagccgc tccatccttc gtatctccta ttctttcagc caatttgtat 3248701 aaatattttc caacctggac attctaatac catgaaaaga aaaatgggag ttgagataaa 3248761 tgacaaaaca gcgacaagac gcttggtcag aggaaaacga tctgctttta gccgaaacag 3248821 tgcttcggca tgtgagggag ggcagcactc agctgaacgc ctttgaagaa gtcggcgata 3248881 aattaaaccg gacatccgca gcctgcggat tcagatggaa cgcagtggtc cgccatcaat 3248941 atgaaaaagc gcttcagctt gcgaagaaac aacgaaaaca gcggatgaga gcgctcggaa 3249001 acgggcagcc cgcgaaaaaa agattattat atcagcctcc tgccgttgat cctgaaatca 3249061 ttcaagaaac cgctgcagaa gagccggtta aaacggaaac accatctgtc gaaaatgagc 3249121 aacctttaat gtctggcgaa cacatgcctt ttgttgatga aagctttaag gaagagttag 3249181 ctagtctatc acacttattg tctcctcaaa cgcctgcagc tgcgcctgag atgacgatga 3249241 atgatgtgat ccgcttcctg cagaattacg aaggcaatca cgagcaatca tcagcattaa 3249301 aaatggaaaa cgagcgttta aagaaagaaa atcaggaatt gcaaaacaaa acagagcagc 3249361 tagaggcaga agttcaaaag cttgaaaaag accaaaaaac gatccaagaa gattatgaaa 3249421 ccttggtgaa aattatgaac agagccagaa agctagtttt atttgaagaa gatgaacatg 3249481 cctctccgtc cttcaaaatg gaccggaacg gcaatttaga aaaattagcg gaatgacata 3249541 gaaaaatccc aaaacgggca gctgttttgg gattttcgcc atgtgcaaaa tccccttttc 3249601 tattgagaaa agagaatttc ctcattttgc agccggatca gctattcttg taaaatgagg 3249661 ccaagcttat gtgaatctat taagacatgt gagctgcctc ggccgttttt tgtttccgag 3249721 gcgcagcaga aatgaccaaa agccccagca tcataagcgc aatgcccagc cacgaggaag 3249781 gcgaaagcat ttcccctatg aaaaacacgc caagcaatga agccgtcagc ggttcagcta 3249841 aagacagcgt gaccgccgcc gaggccggaa ccccggtaag ccctttcgca aacaaaaagt 3249901 atgcggcaca tgttgcaatt aacccgatgt aaaggcttgt tcccagtcct ctaggggtca 3249961 atatccacga gatatctaac tgccataata gcggcgtcag caagatggcg ctgatcatga 3250021 atacaacggc ggaggtcgct cgcggaggct gggttttcat catcgcttta ctgatgagcg 3250081 tatagcctgc aaaagaagca cccgctccaa gcgccataag aacaccagcc acatcaatcc 3250141 gaacattgga actgtcggaa aacagaagcc agcaacccgc taaagccagc acagtcgcaa 3250201 tccaccagga gtttcgcggg cgtttcttca atacagccca ttcgagggtc ccggcaatga 3250261 taggcgcact gccgatggca atcacagttc ccactgcaat tcccgtttct ttaaccgctg 3250321 tgaaaaacag cggctggtaa cacgccatac aaacagcggc taaaaatacg agcggccatg 3250381 cccaattttt cacgtgaagc tcccggctga tccaaaccgc aagcagcatg gcgcttcctc 3250441 ctattaataa cctgaacgct ccaaatgcca gcggtgtggc gctttctgga gccaatgcct 3250501 gaacggttcc cgtggtcccc cagaaaaaag ccgcaatcaa tacaaaaagg ctgtaaatat 3250561 tccccttcat ctgcctctcc cctttaatat ggatgctgat gtcattttat cgtttttctt 3250621 tttgtcgtgg ttatctgtat gtaagaagga cttatctgaa aataagatta ttgaggtaaa 3250681 atgccgcttg agataaaaaa tgcatgccgg catatacagc cggcatgcga agaacgttca 3250741 cccaaatacc tttgcattcc gctcagccat ccggacgagg tttttctcaa attccatttc 3250801 ctcatcaatg gacagtccag ctgaataaag atgggtgctt aacgctttta attccgtcaa 3250861 taaagcgaac attaagtctt gtacggagat gtctttttga agaagctcac ttaaggacgc 3250921 catcgtttcc ggacgtattt ccggatagac gcctttttta tcgttttgtt tgtctttcag 3250981 cgccgcttga tagaatcgtc tgatcaagtc ggccctttca ctgccgcttt tatctgcaca 3251041 gagataaatt tgaacagcga ctccgccgcg aacgcgtctc tgagagatgc cggcgaactt 3251101 tttgccattt atactgaggt catagctgcc gggacaataa gacccttcaa tttcataggc 3251161 ttcgatcttt gcgttgtacg gtctcagcat tcgtctcatc agctcgacca tcgcttcata 3251221 tcctttgtct atatcgatgc ctttcttttc gtcctcgaat atgagagaga tatttaaaac 3251281 accgtcatcc aatacgacgg caagaccgcc ggaattgcgt acgatcacac ggtatccttc 3251341 gctctccagc aaggagatac catcctgcaa aaacgggagg cgtgtatcct gtattccaag 3251401 gacaattgta tcgtggtgca cccatgagcg cgctgtcgcc ggcgacacgc cttttccgac 3251461 ggacatgcat agcgtatcat ccattgcgaa ggattgcttc gcatcaaata aagggccgag 3251521 actggattgg tcaatgactc tccatttcgg ctgcatcagt aaatcaatcg gttggtttgc 3251581 catctatgta aaaccctttc atgttaggct tattgaacga aaactattat atcatttcag 3251641 cagctgtgat tgataattgc ttttcagcat cgtaataaaa atttctttat tttttgtatt 3251701 ctccatgaga ggagaatgaa tgtaagacag cttgcgcttt aacgagaaat tattaatatg 3251761 cagaattgaa atttcgcggt ggatcaaatc cttacgcagc acgcttctgg atagaaccga 3251821 aagtcccatg ccgttaatca ccgcttcctt tacaccttga ttgctgctga tggtaaacat 3251881 tgatttcggc cgaagtccat ttgaactgag tacatgatcg agatattctc tcgtcccgga 3251941 gcctttctct cttgtcaccc acgcttcgtt ctgcaaatcg ctgatcgaaa tctctttccg 3252001 cccggcgagc ggatgctgat ttggagcggc aatgcacatt tcatcctcca tgaacggttc 3252061 aatttccagc tcattctcgt ttgtatgtcc ttcaatcagc ccgatatcag cctgaagcat 3252121 ccgcacacgc tcgctgacct cctctgtatt gccaatcatg acatctagat tcagctctgg 3252181 atacagcttt tgcagctggg ccaatagcgg cggaagaata tactcaccga ttgtaaagct 3252241 tgcagctatt ttcaattcac ccttcacata gtgatgatgc gcatagattt cagccttggc 3252301 ttgttcgtag agaaacacca tttgctttgc tctttgatat aaaatgtctc ctgtcggcgt 3252361 tgtcgtaaag tgttttggcg acctgttcag aagagccgtt tgaaattctt tctcaagatt 3252421 tttgatatgc agactgacgc tgggctggga gatcatcagc ttttccgccg cttttgtgaa 3252481 gtttttttct tctaccaccg ctataaacgt tttcagcacg tcgtaataca aaaaccccac 3252541 ccctgtcatt aatgaaatat atggttatga ttagttttct ttattgtact catatcatcc 3252601 gtcttggtaa agaagggcta tacagaagcg caaaaaaggc agccctcggt cgagagctgc 3252661 cattgtcttc aattttatta cagtgcttgc gccgctgtaa ttaatgcgag attgtaaaca 3252721 tcttcagcgt tacatcctct tgaaaggtcg tttacaggca tatttaaacc ttgcaggatt 3252781 ggtcctaccg cttcaaagtt gcccaaacgc tgagcgattt tatagccgat gtttcctgct 3252841 tcaagacttg ggaatacgaa tacgttagcg tcccctttga tctcggaatc cggcgctttt 3252901 ttctcagcta cagatggaac aaatgcagca tcaaattgga attcgccgtc aagtgtcagt 3252961 tcaggcgctt tttctttcgc gattttcact gcatccgcta ctttttctgt ttcatcagat 3253021 tttgctgagc cttttgtaga gaagctgagc attgccacgc gaggctcaat gtcgaacatt 3253081 tttgccgtat tggcactttc gatcgcaatc tcggcaagat cttggctgtc aggtgcaatg 3253141 ttgatcgcgc aatctgcgaa tacgtattgc tcttctccgc gagccatgat gaacacgcct 3253201 gaagtctttt tcacgccttc ttttgttttg atgatttgaa gagccgggcg gacagtgtca 3253261 gcagttgagt gagcagctcc gcttacaagt ccgtctgcaa gtcctttata caccagcatt 3253321 gtaccgaagt agttctcgtc taataatgct ttacgagcct gttcttcagt cgctttgcct 3253381 ttgcggcgtt ctacgaatgc ttgtacaagg tcttccatgc cttcatatgt atgaggatca 3253441 taaatcttaa cgccgcccag cgtaaggttc aattcttttg cttttgcttg gatctcattt 3253501 tcattgccga tcacaatcgg attcagcact ttgtttcctg caagcttgct gaccgcttct 3253561 aaaatacgct cgtctaagcc ttcaggaaat acaattttaa cgtcttttcc agctactttt 3253621 tcttgcactg ttgaaaataa atctgccaca ataaaacctc ctcaaaaagt tacaaaaacg 3253681 ctttctttta ctagcatact cttcttccaa tcaaattcaa acagccaact ttcattatag 3253741 cgctttcata aaaaaatctt atttttctaa ctaatttaag tgactcaatc ttcccttata 3253801 ggttcttcta ttttgatgga gttatacgga agggatgttc aaggtttctc cacagtagaa 3253861 tcggataaac tatggtatag tgaaggcaat catgaaaaga taatgggagt gaagataaat 3253921 gagtgaacag caaatgacga atgaagcggc aaaaacgctt gacggctggt atgcgcttca 3253981 tgatttccgc acaatggatt gggcttcctg gaagcttctg tccagtgatg agcgccaatc 3254041 tatcatacat gaattcaccg ggttgcttga aaaatggggc gtagcccaaa aagaaggaaa 3254101 aggatcgcaa actctttaca gcatcgtcgg ccaaaaagct gattttatgc tgatgatcct 3254161 tcgtcctaca atggaagaat taaatcaaat tgagcttgaa ttcaacaaat caagacttgc 3254221 tgagttcacc attccggcat actcctacgt atcagtggta gagctgagca actacttggc 3254281 aagcggtgac ggcgatcctt atgaaaatcc gcatgtgcgc gctcgccttt accctgaact 3254341 gccggaatct aaatatgtat gcttctatcc aatggataaa agaagatctg gcaacgacaa 3254401 ctggtatatg ctttcaatgg aagaacgcag aaacttgatg agaagccacg gtttaatcgg 3254461 ccgcagctat gcgggcaaag tcaaacagat catcaccggc tctgtcggct ttgacgatta 3254521 cgagtggggc gttacattat ttagcgatga tgtccttcaa ttcaagaagc tagtgtacga 3254581 aatgcgtttt gacgaagtca gcgctcgcta tggcgaattt ggttcattct ttgtcggcaa 3254641 tcacctttcg cttgatacac ttcctcaatt cttatatgta taatatcccc gagctcgttt 3254701 attgagataa ggactgatcg gccttctgct caagtttgcc gtacttttta tatgcgaata 3254761 cactgagcac aaatccgagg actgtgatgg cggcgcaaat caatccgaca gctgcatagc 3254821 cgtatgccac atatacgggt cccattaaag cagaacctaa tgtcacggcc agattcgagg 3254881 cgagactgta aaacaccatg acttttcctc gatgacgctc tgagcagtca ctcaaaatgg 3254941 tgctgagcag cgtcaccgtc aaactttgca ttaatcccca aataaatagg ctggcgatta 3255001 acagaaacat agacgccggc gcatatggta aacacgccag cagaacgctg atgaccccca 3255061 gcgcaatcaa aagggagcgc atttttccga tgcggtcggc tatctttcct gtaatcacac 3255121 tcatggaaaa cccgattcca taaatcatga taaataagcc cgcagccgtg tttcctccgg 3255181 taaaaacgtc ctgaagatag gtgcctaaaa aggaatacat accgtaaaaa ccaatcatat 3255241 tacaaaaggt tattgtgata taaacaggta cacgagggac tttcagcgca tcccggaatg 3255301 ttcctgcggg ctcttctatt tcttccttgc cgctgttttt atgttgggca tggcggcgca 3255361 tttcaaggag aatcagcaga acaactaaaa cacccatcag ggcgaaaatc caaaacgtcc 3255421 atctccaatg caggacgccg ccgataaatg atccgagcgg cactccgaaa atcagcgcca 3255481 gcgaccagct tgaaacgatc agtcccatca ccttgccccg gtatgtataa ggaacacgat 3255541 caccgacaac tgcgtaagcg gtcggaacaa acgctcccgc agccaatccc gaaagcgccc 3255601 ggcctaaaaa gaagaaaaaa atattttgag ctaaagcgca tatcaccgtt cctatgataa 3255661 aaatcataag cccggccaat aagctcagtt ctctggagta tttatcgcct aatggaacca 3255721 aaagcggcgc accgataaaa atcataacgc cgtaaatact gatagataac gcaaggacgc 3255781 tgacatctga gctgaaggct tttgctaaat ccggcagcag cggtgagatc acaagctctt 3255841 cagatccggc tgcaaatacc cccatcgtta aagccagtgc caacaataac ggaaaatgat 3255901 gttttgtttt gatgtcattg ttttgattgc tgttcattct ttctcaaaca cctcttccat 3255961 aatcttctta tcataaagtt gtattatagt ttagcattgt tttttctcta tttacaattc 3256021 gaacgaaata tttataagtt ttattatttt catttaaatc ccattatata tttctatatt 3256081 tcattctaaa aatacatgag gatgtaacac gtaaaaaaag ctctccggcc tcccggagag 3256141 ctttttctat tgcgcctctg tctgcttttt ttcaatcgtt tcatgattta tacgcttttt 3256201 gatgcttaga tgatagtatg cataacagaa aataatgatc ggcacaccgc agtataagcc 3256261 aattctttga tccggaatga aaataaggct gatcaacacg cagccatata aacaaaatcc 3256321 gagaatcggg actagcggat aaagcggcgt tctgaactcc agatcattca catttccgcc 3256381 ttctgccagg aaacgcctgc gaaagaaaaa ttgcgacgca caaatggaca tccacgcgac 3256441 aactgtcacc atgcccgaga ttgagataca ccataaatac actgtttctg cagccatgac 3256501 acttgtcagc agcgaacagc ctgaaatgcc tagcgtaatc agcagggcat tcatcggcac 3256561 gccttttttt gtcagtctgg tgagaaagga gggacccatt tgatttgatg aaagtgacca 3256621 catcatacgc gacgccgcat acaatcccga attagcaaca gataaaatgg ccgttaagat 3256681 gacaaagttc atgatatctg ccgaaaatgg gatgccgatt tgatcgagta ctgctacaaa 3256741 cgggctttca atcacccccg ccgttttgta cggaaggatg gcaaccaaga cgaacatagc 3256801 gagcacaaag aaaaacagcg tgcgccaaat aacatttcga atggactttg gcagtgtttt 3256861 ttccgggctt tcactttccc ctgccgcaat gccgacaagc tccgttccct ggaacgagaa 3256921 gtttaccatg accagcgtaa acataacggc cagcacccca ttagggaaaa gccctctatc 3256981 agtcataaag ttagacaaaa agggtgtctc ctgtccgcct ttaaagtcaa tcaagccaaa 3257041 cacagcggct ccgccaatca caataaataa tatgatcgcc gccactttga tgcttgaaaa 3257101 ccaaaattcc atttccgcaa agcttctgac agagagcgca ttaatcaaaa agatgacgat 3257161 gccgaacacg aggcaccata tccagatcgg aacggagggc agccaccttt gcatcaaaat 3257221 gcctgctgac gtcagctcta accctactgt attggcccag ctgaaccaat acagccagcc 3257281 aatcataaag cctgtcgact gtcccagaaa tttagtggcg taggcctgaa acgatccggc 3257341 caccggcatg gcaacagcca attctcctaa acaaagcatg acgagataca ttaaaaatcc 3257401 gccgatgata tacgcggcaa tggcgccgag cggtcccgcc tggctaatgg taaagccaga 3257461 gcctagaaac agcccagtgc caatcacccc tcccaaagca atcataaaca aatgcctgct 3257521 tttcatgctg cgctgcaatt catttttatg attctgcatc atccttcccc ctttggttct 3257581 tttgccgtga tggtcatccg gtagctttgc aaaagatgaa cggtggtttg ctgtatgagg 3257641 agaggcaata catgaaatgt gtacggttta tagactcgtt ctgtccattt atggccgtct 3257701 tttccgtaca cgcccatatt aatggatgga atattcagct tgcgtatgtc tttgaacgga 3257761 atggtcccaa tcatattcca cccagggaag ttcctgataa aagaatcaat ttcgccatcg 3257821 gtttcgtgca gtgataaaaa actgccgtct gccaagtagg ggaaaaactt tttgaagaca 3257881 aatgtttcgc ctgtcgattc agcggttttg tcagccgctt ctttaatcac atgctgcaaa 3257941 agctgatctc ttgcgctatc ttctttcaaa tagttatgcg gcaggtaagg aggtgcgtaa 3258001 aatagaatga cttttgcgcc ttgatcgggg tcaagctttt gaagctcttc gattgcctga 3258061 aagcatctca tgcgaagttc aaggtgctcg ttggctttga atgtctgctc gatacactgc 3258121 tcgggatcta ttccccggtt tctcagcttt tctaagtatt gctccaggct atacacttga 3258181 atgccccatg ataaatgttt ctttggcagg ttggctcttt ttacatattc ttcgtaataa 3258241 tctgataatt tttgttctgt ctcccggcat gcttcctcag tgacttcaat aagcaaatcc 3258301 atcatttctt ttgctgttct ttcataaata aaacaattga aatacaagct ggtgctgaca 3258361 gccgtttgca cattatagga ttccttgtta tcacgctgat acaaacagga tgggggcaga 3258421 accaactccc cttcaacctt ttctgccaga tggatgttat tgtggagacg gcttgtgatt 3258481 tcagatgaaa tgaaatttgg gtcaatccct gccagtgtat cgccaacatg gacttcacgc 3258541 ccgtaaatgt aaaagcaagg caacagtttt cccgcggctc cggtatagat atatcttgtc 3258601 tgatcaccat cgtaaagcgg ggtaataaaa tccgtattaa tagcagccaa atagtgaagc 3258661 tgtttttctt tttttagccg gttcagctct gaaatgctgg cgagaatgcc cgaatgctgg 3258721 ctctcctcat cgggattggc cataaacaat acatttcccg gcaacgtctc aaggttctcc 3258781 gaaaaatgca ggagattggc taaatgcacg gcgatgccgc tttgcatatc gacagatcct 3258841 cttccgaaca tccactcgcc tgatttggca tcccgctgaa catcctgatc gaactcatag 3258901 cggctgaaat actcggccaa tttctcacaa tcaaaagcga tatcctttaa agggccgaaa 3258961 tcttcaattc caactgtatc cagatgggca tggtaaatga ctgtatttcg gctttctcca 3259021 tgtcctttaa taaacgcaaa aatatttttg cgtttgtatg ggtcattggg aatggcctgt 3259081 tcccacacat gactggggtt ttcctgaaaa taaggatagc tcgtgatcac ttctttgatg 3259141 aaatctgctt ttgtcccttc tccaacggtg ccgttcacgc tgctgaggct gaccagagat 3259201 gctgtcagcg cctccactct ttcagccgga ttcatgtgac tgatttttgt atactgcata 3259261 aattgtcctc ctgatcaaaa agttgaaatc gtgcgatccg ctaaagaatc gcacgatttt 3259321 atttctctca aatcaaaaag cttcggacgt tgttttggct tgcatatgaa gaattaagta 3259381 atcgggaccg cctgcttttg agtctgttcc tgacatatta aaaccgccga acggctgata 3259441 gccgacaatt gctccggtac atcctctgtt aaaatatagg tttccgacat ggaaatcctc 3259501 gcgcgcccgt tcaatgtgcg cacggttttt cgtcagaagc gcacctgtta atccgtattc 3259561 cgtgttattg gcaatctcca gcatatgatc gaaatcacgc gctttgcaaa tcgcaacaac 3259621 cgggccgaaa atttcttcct gcatcaagcg ggcgttttca tcaacatctg caaagatcgt 3259681 cggctgaata aagtagcctt ttgaatcatc gccttctccg ccggccaata gcttgccttc 3259741 agatttgccg atttcaatgt atttcatcac tttgttgtag gatgcttcat gaatcacggg 3259801 acccatatac gtatcaggat cttctggatt gccgacagtc agcgttttgg tcagcgccac 3259861 agctttttcc accacttcat catacacatc ctgatgaatg accgcgcggg agcccgcaga 3259921 acacttctgt cctgaatatc caaatgctga atacacgata gaggatgcag caaggtcaag 3259981 atcagcgtcc ttgtcgacaa gcactgtgtc ttttccgccc atttctgcaa ttacccgttt 3260041 gagccatttt tggcccggct gcactttggc agctcgctca taaatccggc agccgactgc 3260101 acgggaacct gtaaatgaga caaaccgtgt cttcggatgc tcaactaaga aatcaccgat 3260161 ctccgcacca tctcccggaa tgtaattcag aacgccgttt ggcagacccg cttcctccat 3260221 gacctcgaca aattttgctg ccactaccgg ggctgcgtca gccggtttta agagaatcgt 3260281 atttcctgtc acaatcgctg ccaccgctgt tcccgccata atcgcgagcg ggaagttaaa 3260341 tggagaaatg acgatgccga cgccaagcgc ttcgtaatga tattgattga cctcgccagc 3260401 acggctcttc accggagccc cttccttgag ctttaacatt tggcgcgcgt agaactctaa 3260461 aaagtctatc gcttcagccg tgtccgcatc tgcttccttc cacggttttc ctgcttcctt 3260521 cacaagatag cttgaaaatt catgctttct tctgcgcaaa atagccgctg ccttaaagag 3260581 aatatttgcg cggtgctccg gtctttgttt tttccaggaa tcaaatgcct gcaatgcggc 3260641 ttgcatcgct ttttcagcaa gctcttgatc cgctgtagac gcgtacccaa tgatctcttc 3260701 tttatttgcc gggttaatag aaatgatttt gcggtccgtt tcaatttttt ctccatttat 3260761 gacaagcgga taatgcttgc cgagctgagt gtttacaaag gccaatgact ccccaaatgc 3260821 agttttattc tttgcttccg taaaatcggt aaatggttcg tgcgcgtatg tgactgtcat 3260881 atgtagtccc cctcgtgtta tgaaatatat cttcgcatat gaataaaaat gcaagaatca 3260941 tgccattttc ttgtcttttg ctgaaaaaac ttgttgaatc gaacagaaat ttgtctaaca 3261001 ggtgatcacc tttctctttt tccgatcttg aacgcaaatt tattttgcgt tttttgctct 3261061 ttacgcaaaa aacaaatgca aaattatttt gcggaggctt ctcaaattag acccatccgc 3261121 ggaaacgcga tgcttctgcc gattttctga tgcccgtcat gtaagccgcc aaacgcatat 3261181 ccactttatg tgttgccgct gtttgataaa ttgtttcgaa cgagctgacc atgacgcttc 3261241 tcagtttttc tgcaacctct tcttccgacc aataatatcc ttggttgttt tgcacccatt 3261301 caaaataaga aaccgtgacg ccgccggcac tcgctaggat atccggcaca agcagcacgc 3261361 ctctttcatt caggatctta gtggcatcaa tggttgtcgg gccgttcgcc gcttcaacga 3261421 cgattgacgc ctgaatgtta tgtgcgtttt tggctgtgat ttgattggag atcgcggcag 3261481 gcactaaaat atcgcaatcc ttttcaagca gctcctcatt tgtgatgacg tcagtaaata 3261541 aattggtgac cataccaaag ctgtcccgtt tatcgagcaa ataagggata tcaaggccgt 3261601 ctgggttgta gagcccgcca ttggcatcag aaatcccgat caccttcgcg cccgcatcgt 3261661 gcatgaattt ggccaggaag ctacccgcgt ttccaaagcc ctgtatgatg atgcgcgcgt 3261721 tttgcagctt gatccctttt ttcttcaccg cctcttcaat acaaatcgtg acgccctgtg 3261781 ccgtcgctgt ttcccgtcct tgcgatcctc ccaaaacaag cggtttacct gtaataaagc 3261841 ccggagaatc gaattcccgc agccggctgt actcatccat catccacgcc ataatctgcg 3261901 aattggtgta cacatcggga gctggaatat cctttgtcgg accgacgatc tggctgatgg 3261961 cacggacata ccccctgctc agcctttcca gttctccaaa tgacattgtc cgcggatcac 3262021 aaataatacc gcccttcccg ccgccgtaag gaagattggc aatcccgcat ttgagcgtca 3262081 tccaaatgga taatgccttt acttcctctt cattaacttc tggatggaag cgaacgcccc 3262141 cctttgtcgg accgacagca tcattgtgct gtgaccggta gcctgtgaac actttgacgc 3262201 tcccattgtc cattttgacc ggaatgcgga cagtgagcat tctctgcggc tctttcatga 3262261 gttcatacat atctcccgga taacccagct tccgaagggc ttccttaatg attgtttggg 3262321 tagacagaaa taagttaaga gcttcttttt cttcatcttt cgagacttgc tttgctgaca 3262381 tctttttcac ctcattgttt ttttggccgg ctgtaatgta agcgctttaa aaaatcagcc 3262441 cgccaattcc tttcttcatt ggattcaccc ttatcatcat gcaagatccg taccagcttt 3262501 tgaatccaca aaaaaagaga ctgaaaacat ctcagtctct gactacaaat ctatcgatta 3262561 acggggatca atcaccagct gcgtttcagc ataaaaactg ccgattccca aaccgtttac 3262621 tacatcgcct ttaatcgtgt aagtgcctgc gcgaggaaga gttttacgca ccatgacaag 3262681 gtcaaattcg gatgcgccta acaaatcaag cgtaagcggg agtctgactg tttttccatc 3262741 gtttaaaatc tgtgtttctt tcagtgttct tccattcact gaatctcttg tcgtagcatg 3262801 aaacccgtca ggaaattgaa attctaccgc tccaagagaa agcaccgcat ttggtttata 3262861 tgtcacttca atatcagaaa tggtccactc tttcgtgctg ttaactgttt ttgcctcgat 3262921 tgatgcagac tgtgcatgag cttggcccga aggaagtaag attgatagta aaacagctga 3262981 actgatgaat aatgaagata cgaatgaagt tctttttagc atgacatttc cccctaattg 3263041 attgttgaaa tttggccaga gcgtcctctg cagaaaaagc gctttttcat aattcgcgaa 3263101 ttaccagttc tttttcttaa aaattaatct atcatcattt tccatggaag taaatgtttt 3263161 ttaaggaata ttaacacttg gaattcaatg agaattcctt cctgtttata caaggttcaa 3263221 atggacgatt tccctctctt tttctagtaa catctgcctg acattttata tcttttatcc 3263281 tattttaaaa aagggcaaaa aaagtcgaag atgcctctgc tcttcgattg atcacgttcc 3263341 tatttttatc tgaattcagt gttccagtta aaaccgatcg tctcatcatc ccacggaatt 3263401 cttttttcat caggctgatc cgggttatac gacatggtgg taaaatagat aattgtcagc 3263461 ggcgtctctc ccagcactct atatccgtga gccacccctt ttgggattaa taacagcatc 3263521 gggttgtctt cgcccatata atagacgtcc gtttctcctt ttgtctttga atcctctcga 3263581 agatcgtata ggacaacctg agcgtggccg gttgggaaga accagagatc atcctgcttc 3263641 tcatgataat gaaatgcctt aatcacaccc ggatagcttt tcgaccaaga ggcctgccca 3263701 aaatgctcaa ggagattctc atcgtcccgg accagctcag caaaaaagcc tctgtcatcg 3263761 ctatgcttca tcaatttttt caccttgact ccatcaatca cacgcactgc tcctttcctg 3263821 caaatactct cgtaacgctt cccgccagtg gcgggggcgg atgccggctt cttcaatagc 3263881 ccgatggctc agcacagagt atgccggacg gggcgttttg ttcccgtatt cctctgtcgt 3263941 tacagacaaa atggctgttt ccagcccgct ttcttccata attgccgtcg caaactcata 3264001 ccagctgcat atgcctgaat tgctgacatg atagatgccc ggcggatggc tgaacagctt 3264061 gatgaccgct tctgctaaat ccttcgtata agtcggcgaa ccaatttgat cgctgacaac 3264121 ccgaagctct tgtttcgttt cagcaagttt cagcatggtt tcaacgaaat tactgccgcc 3264181 atgtccgtac acccacgatg tcctgatgat cgtgctgtct tttgtcgtta atcgtatcag 3264241 ttcttctccg agccttttgc ttttgccata aatggttttc ggatcgaggg gatcgtcttc 3264301 cctatatggc tgggttcctt tcccattgaa tacatagtcc gtgctgatat gaacatattg 3264361 agctccgatg cgggttgact caagcgctgt ataataagcg ccgattccgt taatcaagta 3264421 cgctttatca agctctttct cgcattgatc aaccgacgta aacgcggcgc tattgaccac 3264481 gatatccggc tgataatggc caaacgaatg ccgtactgag cgctggtcag caatgttcat 3264541 catcttcttt gttaacgcaa tgacctcata tccggcttgc ttcagctggc ggcatagttc 3264601 caagccaagc tgtcctcccg ccccagtcac caataccttt gtcaatcaga tcaccttctc 3264661 atcggtcatt gtctgtatac cactgaatcg tacgcgcaat gccttcttca aacgtcactt 3264721 cctgccgcca gcccagttcg tttttcagct ttgatgcatt gatcgcatag cgccggtcat 3264781 gcccttttcg gtcttccacg tgggcgaaca attcctcaca gcccagatgc ttcaaaatga 3264841 cactcgccag ctctttattc gtgcgttcat ttccgccgcc gatgttatac acctcgccgt 3264901 cggtcccttt ttctaaaatc agcttgatcg cgcggcaatg atcctccgca aacagccagt 3264961 ctcggatctg gagtccatcg ccatacagcg gaacaggcag gccctgcttc gcatgacgga 3265021 taatcgtcgg aatcattttt tcgctgtgct gataaggtcc gtaattgttg ctgcatcgtg 3265081 taatgatggc cggaagcttg tgggttttca cataagacaa cacgagcaaa tcagagcttg 3265141 ctttgctggc tgagtatggg ttattaggag aaagcggcgt cgtttctgta aacgcgggat 3265201 catccgcttt taaatccccg tatacctcat ctgttgaaat atgaatcagc ttcttggctt 3265261 ttcctttcaa gaccgcttcc gccaatcggt atgtccccat gacatttgtg gtgataaacg 3265321 gctccgcttg ggaaatgctt ctgtccacat gcgattctgc tgcgaagtga atgacgccat 3265381 cgtaggtctc gtcaaaagcg cggtcgatat cctcctgaac gctgatgtcc ccttttacaa 3265441 agcgaaaacg gctgttttgc tttaattttt ccatttcctc cgggtggctg gcgtacgtca 3265501 gtttatctaa aacggtaatg cgcgcatccg tttccctcag catgagcttt gtaaacgtga 3265561 gcccgatgaa gccggccccg cctgtaatta aatatgattt tgccatcact tttcgtcctg 3265621 tcctttccgt aaagcctggt gtacaagctg ggaagcgaga taaagcgatt cgtgagttcc 3265681 ggcatctacc caccagcctg ataacacatc atacgtaagc tggctgtttt cgatgtatag 3265741 attattcaca tcggtgattt ccagctcgcc gcgctttgat ggtgatattt gttcaatata 3265801 tgaaaacacc tctgcatcat acatataaat gccggtaaca caaaggttgg tcggtggctg 3265861 ttcgggcttt tcgatgatgg aacgaatccg cttgtttttc tcatcaatct cagcaatccc 3265921 gaaacgttcc gggtcatcaa cttctttcag aagcactttt gctcctttcc cctgctgttc 3265981 aaagcgttct gtataaggct ttaatgaatc ttcaaatata ttatcaccta ataataaaat 3266041 gaaagactct tttttcgtaa agcgctttgc ataagacagc ccatccgaaa tgcccgatgc 3266101 tgccggctgt acttgataag tgatagtaac gccaagctct tccccgttcc caagcagttt 3266161 gtaaaattgc ggcatatgct ccttttggct gatgagtaaa atgtctttta ttccggcttc 3266221 ctgcagcttc ataatcgacc agtatatcat cggatacggg cctacaggaa gcaaatgctt 3266281 gttgacggct ttcgttaagg gcataaggcg tgagccgttt cctccggcta aaataacacc 3266341 tttcacatta acacttcctt acatgcattt ttatatctct tgttcatata aatcttgaag 3266401 aatagctgtt acccgtataa tgcctttgcc atccacgagc ggccttcctc ccttgtgcaa 3266461 agaaaggcga agaggatagc tgctcataat gcgtgacatc tgatagatga gtgtttcatc 3266521 cggtacaagc tcacccaatc caagatcaag agcggcgcct tggtcagcaa atgttttggc 3266581 tgtagccgtt tgatgctcaa cctgagaaag aacaaggcac ggcacgccga tgcaaatggc 3266641 ttcatataga gagatgccgc cagcgacaat ggctgcgtcc gcttgtttca tcaaacctgc 3266701 catatcattt gtctgttcga tcatcttgta ctgcggcttc ttttcgatcc gccttcggac 3266761 tgcctcttga tgcggtgaag cgctccccat cacaaacatc atgtttttgt cttttatgtc 3266821 ggggacttga tcagcggcag ccagcacttt aaaaataagc tgcttcggat cacttcctcc 3266881 taatgcaaca aggatattgc ggcagtcttt cttaagtgtg taatcctctc ttgcggcctg 3266941 aaaggcgggg tgaagaataa gatagtccgg accttcatag atgcgtgtgt ttccctgaac 3267001 gtacaccctg cttctgatgt caccgtaaat tccgttaatg actgcgtcac tatattgaat 3267061 cgatttaccg tttttctctt caaaaagaac aattttcgca tctgtctccg tctttatttt 3267121 ctttaacagc tctgcaggcg cgcctagaat atcaaacaaa agcaaatcaa gcttcttgct 3267181 ttttatttcc cggagaataa attcgtgctg ctgcagctcc ggctttacga tgacctgcca 3267241 atgctcttca tgaagaaacg cttcagaatc ctgattcgta taaaacgtaa tcaagcatcg 3267301 ctgtttgagc ccctccgcaa gcctcttcat ccggacaaca tggcccattc ccttttcata 3267361 gccgccgtct gcgaagatcc caacatgcat ggctagtcag cctctcgttc ggttgccgca 3267421 tcggggttcc ggttcagaag ggtgataagc tctgaggcgg atacatcggg gcgctcgcct 3267481 gctttttgat agagggcctt tatcgattca tagtcttcct ttgtatcaat ggtcagccga 3267541 tattgagggg cgcgaaatcg ttccggcgcc tctaaaaact gaacacgata aagagctgga 3267601 tgattcctta tatataacgt gacatgctcc tgatattgat cctccaaagc ctgaatacgg 3267661 ctgatgtcaa ttaacaggtt ggcgttgacc acttcgccgc aaatccctaa tggggcattc 3267721 aggatatacg tataatccga gccttgatca aaatgcgcct gaatcattac atcgagcagc 3267781 tcaggatcga caaacggatt atcacctgtt aaccggatga tgactgacgg tttaacagct 3267841 tctatgacct tcacaaacct atcgaggaca cgttcttcgc tcccgcggaa aacacgaaag 3267901 ccttgtttga tacagtgcgc ctctaatatg tcgtcagttt ctttgtcaga cgtggcgatg 3267961 acaagattat cccgatcctt ttggtaaaac gcgctttgcc ggacacggtg aacgagaata 3268021 tcaagtaaac gattcgatcc gagcggccga agcacttttc ccggaagcct tgttgaaccc 3268081 attcttgctt gaatgataaa gagaatatca ttcatgaaac gggctgtcct tcagtaaaat 3268141 gtcatcccag acaatgcctg tgtcggctgg aatgtctctt acagcccgaa caccgctggt 3268201 cagcagttca aaaaatctcg ggtgcagccc ctgcggcttt tgtccgggcc gaagcactgc 3268261 gatattgtct tcactaaagg cttcaccttt ttgaatcgga gctgttgtaa aaatgcctct 3268321 gtatgcaaag tttctgattt ctccttcgat ggcggtcgtt gttttgtatg aactgccaag 3268381 cagtttttca gagaccggct ttgtgatccc ctgtttcagc tcagcttccg ttttcctgat 3268441 gccatcgacc atttctttca attcatccgg atttaatgca aacgagtggt cagcacccgg 3268501 cagattttta tcgatcgtaa aatgcttttc tatcagtttt gctccgagcc gaaccgcggc 3268561 acacggcgct tctgtcggat gctcgctatg atcggagaag ccgattaccg cctcaggaaa 3268621 agcggcggca agcatcggaa tgacgctgag gttgctgtac tccggcggtg ctgggtattt 3268681 cgccacacaa tgcattatgg caatttgatt gtttccctct gccctgatgg tgcgccaagc 3268741 ttcgtgaaca tcagagattt cagctccggc tgtcgagaaa atcatcggcc tgttcagccg 3268801 ggcgacatat ttaagcagcg ggagatggtt aatttcatag gatgcgattt taaaagcgct 3268861 cggcgaggta gactgaagca gatcagctga cccctcgtca cataccgtac ttaaaaagat 3268921 cacctgcttt tcgcggcagt aatccaatag cggtaaaatc cactcagcag gcatttccat 3268981 agattgaacc aaagaaaaaa tagagacgtc cttgcccgct gccgtcttgt acaaaccagg 3269041 atctttctgg tacatcctat cagcttggaa catttgaaat ttcacggcat ccgctcccgc 3269101 ttccgccgcg gcgtctatca gcgcaaaagc ctgatcaagc ttcccgtcat gattaatccc 3269161 cgcctcagca ataataaaaa caggagcgtc tttgcctaca gttttattcg cgatctgaaa 3269221 cgctgccatt atttcgcctc cttgcccggc caaatatgat aatagtaata cgattgttca 3269281 gcggtgaagc ccattcgttc ataaaggcgg atcgccctta cattgtgaag ctgcgtcccc 3269341 gctgttaccg ttctatgctt ctgggtctcc ggttgttcta tgagattcgc caataaatga 3269401 aacgcaatac gtttcccttc aaatcccggc tttacagcca tcaaatcgag aatgcactca 3269461 tcatctcttg ataagccctg aagatagccg atgacctcgc cattgtgttt agcgacaata 3269521 ttgaccgccg cccttccatt cagattgttt cgtgtccact cctgaaatat ttcgtttgct 3269581 gcatcgcggc tgagatgagg atcctgaaaa tatctgcttt ttgtaaacga gtctcgggcc 3269641 agctcacata tcgcttctgt gtctccgggc tcaggcgggc ccagttcaaa aaatggcggt 3269701 gttttgtcat aaaaagacgg aggcatcgcc agcttcagca aactcccgac aaagtaagag 3269761 gatggctgct gttgtatcac atgcgcggct ccgatatctt cagccggaac acggacaaag 3269821 ataaaatccg tttcatccat ttggcgtaca gtataaaaag cttcaaacag cctctttagc 3269881 tgcccggtac tatttgccgc aagaagtttg acgttcatga ctttcttctg aagcaccttg 3269941 ctttcccaca aagaatcttc gtaaagcaat acgccttgga gcctgctgtt ttcaaaaagg 3270001 ccgagggaaa attgatacgg aacatccaat gtaagctttc tgctttggag aaattcctca 3270061 attgcctctt tggagacatt ttcttttacc gtatacactt aatcagcccc ttttacgata 3270121 tcccgcacag cttcaatgac atcatctaca tcatcgtcag acattgatgg atagagcggg 3270181 agagaaaggg ttcgtttata gtaattcatg gcattcggaa agtccgcttc cttatatcca 3270241 aattgctttt gataatacgg atgaatgtgt actggaataa aatgaacgct agtgccgata 3270301 ttgtattcat cctttaaagc cgtaatcatt tcgctgcgcg taaccccggc ctttttttca 3270361 tcaacttgca gaacatatag atgccaggcg tgcctgccgt catcatggac aaacggcgtg 3270421 atcagcccag gaatctgctg aaaagcggtt tgatagcggc cggcaatctc ttctctccgt 3270481 ttctgcatat catccagccg tttcagctga tgaagtccga gggccgcctg caaatcaaac 3270541 atattcatct tatagccggg cgattcgact tcatagtacc agctgccatt tgaagaataa 3270601 cggttccatg cggctttact catgccgtga aggcttagca cccgtatctt atcggcaagc 3270661 tcctcatcat cagtcgtcag catgccgcct tcccctgtcg cgaggttttt ggtggcgtaa 3270721 aagctgaatg ccgttgcatc cccgatagaa ccgatcattc tttgcttata agtcgtatat 3270781 accgcatgtg ccgcatcctc cagcacgaat aaaccatgat tttgggcaac agccaatatt 3270841 gcatccatat cgcaggactg cccgccaaag tggacgggca caactgcttt cgttcgcggt 3270901 gtgacggccg cctcaagctt taccgggtca atattgagcg tgttttcgtc aatatccgca 3270961 aacacaggcg tcgctcccgt atgaataatc gtattggcgg tcgagctgaa cgtaagcgga 3271021 gaggtaatga cctcgtcccc gggcccaatc ccttttgctt tcaaagccaa aaataaagct 3271081 gcggtacatg aattcaccgc cacggcgtgc ttcgccccga caaacgcggc aaactctttt 3271141 tcaaactgct gaaccttcgg gcctttagag agccatcccg attcaagcgt ttctgtaacc 3271201 tcctgaattt cttccttacc gattaacggc aatgagtaag ggagaaaatg atttctcttt 3271261 tgcaccattt ctttgcgctc ctatcatttt attcagtatc ttcccgcctg taatcaaccc 3271321 ctgttttggc tttcagttcc gcaaataaag catttgttga ttctgccacc ggataattag 3271381 ccgctatgaa tgccaggcgc gcctcttctg ctttttgatg cacgtcggga cttcgaagaa 3271441 cctcaaccaa ggtgtgcgcc agttcatccg gctggtcaaa cataaaatcg ccaagagact 3271501 cataatacgg atacgagcga tttccggacg attttcctat cagcacaggc ttttgaaaca 3271561 gcatggcttc aagaccgact gtcgaggttt gcgtcactgc ggcatcaaca tacggcagca 3271621 aatcataaag ctccagctcc tttttgatga ctctgcatgc ttgatgtttt ttcgccgcct 3271681 cgtgatacag atcaagcttg ttttttccga tttcccacgg gtggggtttg ataatgattt 3271741 gcagctgctt ctgatcagaa agcccctgca gcacaccgga ataaaagtct tctgaaaagg 3271801 gctgagtggc aatgagcaca atttttttag tcggctgaaa agcaagtttt cgatagaata 3271861 tggacatatc cataggcgtt ctgttaaaaa tctgatcgaa gcggggatgt cccgttacga 3271921 gaatctgctc gggtttacag ccttttcgta tgaaccactc tgcttcatac gcaccaaaaa 3271981 cagcttgata ggttgtaaaa acaggaatga aggcttcatc tcccatcaat gcgccatgct 3272041 gaagacaaat gctgacggcc ccttttcttt gacacatgag agcgagcacc ctgctgtaaa 3272101 tgtcttctgc cgttccgaca ataacagctg aaatcttttc ctgttcaaac agcgcatcaa 3272161 ctgtatcaat ggcctctata aataaaggaa tatctttgaa aagccggtcg cgaaacgctt 3272221 gatcaccaaa tgccgggtga tcatcataag gggcgagaag cgaacaggct gtttcgagat 3272281 actgcttcga atcgcctttt tggcatgaat ccgcaatctc ccgcttgcta attacaggca 3272341 gatcacaata atgcggcaaa ctccatctgg ccaaaacagc cgttttttca ggatcaaatt 3272401 gatagtaatt ttcgtttgaa aaacgcaggt aatcaaagtg caaaatgact ttccctttaa 3272461 caggttcgtc atttgtttta acgatgtttt ggattctttc ttcaaaaaac ggctgaatct 3272521 gtccctcatc gatatgctga tccaccgatc cgaataattc cggttcttct tccatcatca 3272581 ccctcagttc agggctgatg tattgataaa aattactgat aagcccaagc ggaatccctt 3272641 tgtagcgaag tttgtcaaaa agctccacgt acttccggta cagcacccaa taattgctta 3272701 aataggccga caagctctca ccccattcca agctttttta atgattcacg cagctctcgg 3272761 caatttcgct gcggaggaag gttcctgaca aattcatttt tttctaattc aaacagctga 3272821 aagtgaatcg attggtcggt aatataattc aggtccagct cctcatccag tgggtaaaac 3272881 ggataaaaat gattgactct ccaaaagaac cgggcatctc ctatacggta aaacgccggg 3272941 ctttcatccc aataggagcc aaacttctcc tttaccttct caagcaccga atacctgtgc 3273001 atcaccgagc aatgatcaat tgcgcacggc gcgttccatg tcacttgagc ggcaggcctg 3273061 acagtttctt ttacaatgtc acgattctcg tttaaatgat aggttttgga ggctgagtaa 3273121 atcacagcct tttcaggatg ggtatcgagc tcccgcacca ttttcaggag gcggtccggc 3273181 atatagatgt tgtcatccgt cgcataggtg atatattcac cctccgccat ctcaatcgcc 3273241 tgattgatca gtgccgcgta tctcgttttt tctgttcttt ccttcactcc agatatatcg 3273301 ctttgataaa aacgcactcg gttatcattc aaaaaaggac ggattacatt cagcgtctct 3273361 tcattggagt tgtcatccat aataaacaat tcaaaatctg aaaacgtttg tgagagtatg 3273421 ctagaaatgg actttgccac ataatcgctt ttgttatagc tcgtcataat gactgatact 3273481 ttaggcaaat cctacacctc cttcttggaa cttcacacct gaaactatcg ttatcttatg 3273541 ttgcttatgc tcaagttgcg ctagggatac aaaccaatat gcgaaaagtt tgtgtatgtt 3273601 tctgaaaaac agcggctgcc cagagcgaaa tctgatcggt ccgctgttct ttttcagcat 3273661 aatccaagca tcagcctcat aaggtgaaag agataaaaat cgcaccagcg actaagatcg 3273721 ttttccatcg gaggtgagtc atcgcggagc gttcacctat acatccagaa catgttttga 3273781 atggttttca taaaaaggag gaacgatatg aaaccgaaaa aaaatcaata tcagcaaatg 3273841 caggcatttg ataatatgca ggggtatcag cctcagtttg gcgccaaccc gtacccgcag 3273901 caaggccaag gctcacaaat gcagacaatg gggatgcagc caatgatgcc aatgcagcag 3273961 ggacagcaag gacaacaagg acagcaggga tttggattcc cgggccagca gcagggcggc 3274021 ggttttcaaa ttccatcggg gcctacaccg tcaggaccgg gccaaagcgt tcccggcatg 3274081 ctgcctgttg aggaatctta catcgagaat attttgcgcc tgaatcgggg aaaaacggcc 3274141 accatttata tgacatttga aaacagcaag gaatggggct cgaagatttt tcgcggcgtc 3274201 atcgaagctg cgggccggga tcacattatt atcagcgacc cgaaatcagg aacacgctac 3274261 ctgctcctga caatctacct cgattacatt acatttgatg aagaaattgc ttatacgtat 3274321 ccatattcca tggcgtccta ttcgccaaga taagaaaaaa gccaatcact catatgatga 3274381 ggattggctt ttttgtttat agatatttga cggctgcgac aacgatcata atccaagaaa 3274441 taataaacgc cacaccgccg agcggggtga tcgctccaag aatggagatt tgcgtcacac 3274501 ttagaatata taagcttccg gaaaacagca caattcccgc aaacatcagc cagccggctg 3274561 tcgtgacact gcctatgccg gataatttat cagccagaaa cgcgacaacg aataacccaa 3274621 gggcgtgata catatgatac tgcacgcctg tgtgccaaac ctgaagatac ttatcaggta 3274681 ttttcccttc taatccgtga gcgccgaatg ctccgagtcc cacggcaagc agggcgttaa 3274741 tggcccctaa tatgataaaa actttcatct atctctcccg ccttttcgtt aaactcatat 3274801 catttatctt atcgcacctg caccaaaatt caatgtttgt tctccgttga cacgagattg 3274861 tcggattttc tcctgcgcca aagctggaac tggtcagctg ctattgcagc aagcgtccct 3274921 aatacgagcc cgttgcttaa tagagaaata aataccggat gcaatccctt taacgcagtt 3274981 tcaggaacaa acatgatacc gacccctgtc agcagtgaga taccgatgat agacctcacc 3275041 ctttttgatt cttctttctc atatgaatca aattcggcaa aggccagacc gcccattgcg 3275101 gagaacacaa caaaattcac cgcaaatcca acgggtgacg gcaggctcgc aaacgtattc 3275161 ataaaaaacg ggatcacgct gatcacgata accagaatac tgccgagcat aaacggtttt 3275221 ttagaaggca tcttggtcgt ttcaataaaa cctgcggctc ccgaaatcgg aacaggcgca 3275281 atagctcccg tcaaaccgct aagcagatgg ctgaatgaag ctgcaaaacc ggcatggcgt 3275341 tcatgatgct ttccatcagg ctgtttgctg aattttttca tggcgatgtc cacgaccttc 3275401 atgctcgcca gcatattcac gatcagcaag atggtaataa aaatagaagt gatgatcagg 3275461 ccgctgttaa ataacggggt cccaaaagga aacagggaag gcagctgaaa cagccggtcc 3275521 ggcatttcaa tcggctttgc ggctccggca gccgcaaaca gcacccaccc gccgaacaag 3275581 gctaataaaa tagaatattg cttaaaaaac atgatgttcg aatttgtcat tataaaagcg 3275641 gcagcgatca caacaagcgc caggccaaat acaagaccgt ccaccccgtc ctgtcgataa 3275701 ccgattccga gaattccttt tataatgggc tgactcagct gcatgacaag aagcaataaa 3275761 tagacgcccg ttacaaccgg agtaaacaat tttgcaagtc tgtcaatgac cttgaaaaca 3275821 cttaacaaaa agaaacatac agcgcttaca agaagagctc cctgcaaacc ccgcagtgtg 3275881 tctccatatg tcgcaaacac agttcccgtc agccctgcgt aaatcgtata cactccccac 3275941 cacaagccgg ctgggctttc attgatcggc agtctgtggc ctttcaaaca ctgaatgacg 3276001 gcggcaattc ccagtacaaa aaaagtgctt tgaatcaatc ttgcagaatc tgagtgatcc 3276061 agatgaaacg actgggcaac cgccaccgga acaacaatcg ccgcagcaat aataaacgct 3276121 gtccattgca gcgcgccaag aaccaatttc acgtaagctc aacctctctc tttaaaaatc 3276181 aaataaagac tctccgtttc catcctcttc ctgcttctct ttttcttgct ttcgatattt 3276241 gtttaatccc gcgctcccca tcattttttc catcatcagc tggtctgtcg atggcggcgc 3276301 ggcgggactt ggcgtaacgc tcggctgtat gcggggcgcg ctcgcgttct ccggctgatc 3276361 aagcacgaca tcacacagag aacggacaac cgctacataa cgcttcagct cctcatcccg 3276421 ttcagccgtt tttgcttttt ttagctcttc ttccatcttt tgaatcaaag cagatatatg 3276481 aatgttcatg aagcaccctc caaaaaaata aatgttgtct tcctgcattt tatcaaattc 3276541 ctgctgaaaa cgcagatatg agtttgttat tttttctgac aaaccttgcg cgattgacaa 3276601 gcagaagaga tttttcacat aataaatcac cataccttac aaaaaggaga aacggaatga 3276661 acagcatccc ctctatcatc agcaagcata aagcctattt tgcggcggga catacgagac 3276721 cgcttgaatc gagactgaac attttgcgaa agctgaaaca agccgtcaga actcatgaag 3276781 ccgatctcat agccgctctc taccaggatc tccataaatc cgagcaagaa gcatactcaa 3276841 cagaaatcgg aatcgtcttg gaggaaatca gctttgtcat gaaacggctg agaaaatggt 3276901 ccaagccgaa acgagtcaaa acgccgttga ctcatctagg ctccaaaagc atcatcatcc 3276961 ctgagccgta tggaaccgtt ttggtgattg cgccttggaa ctatcccttg cagctggcgc 3277021 tttctccgtt gattggcgcc attgcggcgg ggaacacggt cgttctcaag ccatcagaat 3277081 atacgccggc tgtttctgct attctttcca aactcatcag cagcgttttt ccaactgatt 3277141 atgtcgctat ggcagaaggc gggcccgatg tcagcacagc attattacag cagccctttg 3277201 actacatttt ctttaccggc agtgtagctg taggaaaaat cgtcatggag gccgccgcca 3277261 aacaattaat tcccgtaacc ttggagctcg gcggcaaaag tccctgcatc gtccataaag 3277321 atgctgacat tcagcttgcc gccaaacgca tcgtcttcgg gaaatttaca aatgcgggac 3277381 aaacctgcat cgcaccggat tatttatttg tccacgagga catcaaaacg aagctcacag 3277441 aagaaatgaa gcgtgcgatc agagaatttt acggccctca gccggaacgg aatccacagt 3277501 acggcaaaat cgtcagtgag cgccactatc agcggctgct cagctttctg aatgatggca 3277561 tcccgctcac aggcggacaa tctgatccca atcatcacaa aattgcgccg accattctcg 3277621 aacaagtgag agatgactct ccagtgatgc aggaggagat tttcgggccg attcttccgc 3277681 tctttacata ccgcaatatc ggggaagtca ttgagaaagt ccaatcgcgc cctaagccgc 3277741 tcgccctgta tctcttcacc acaaacaaag aaattgagcg cgctgtttta ggaaatctgt 3277801 cgtttggcgg gggctgtgtc aatgatacgt taatgcatgt tgcgacgccg tatttgccat 3277861 tcggcggcgt cggggaaagc ggcatcggca gctatcacgg gtttgacagt tttaacacat 3277921 tcacgcacaa aaaaagcgtc gtcaaacaaa cgaaccgttt cgacttcgca tttcgttatc 3277981 cttcctccaa aaacgggctg cgaatgattc gaaaaatact caaataaaaa agcgcagatc 3278041 acctgcgctt tttacaaatc cttaatacac caatcaatcg gcgcctctcc cattttctcc 3278101 aaataggcat tcgcccggga aaacggtctg ctcccgaaaa atccgtttct cgcagaaaac 3278161 gggctgggat gcgtcgattc aatgataaaa tgcttggagg tgtcgatccg ttcttttttc 3278221 atttgagcat gccgtcccca caaaataaag ataaccggcc gctctctttc actcagcacg 3278281 tcaataattc ggtccgtcag tcgctcccag ccttttccct tatgggaatt cgcctgtccg 3278341 cgccttactg tcagcacagt attcagcaaa agaacgcctt gctttgccca gctcacaagc 3278401 gacccgtgat tcgggatgct gcacccgatg tcctgctgca gctcaagaaa gatatttttt 3278461 aacgaaggcg gctgctttac accgggcttg acagagaagc ttaaaccttg agcctgtccc 3278521 ggcccgtgat acggatcttg acccaaaatg acgaccttga catcatcata tgatgtataa 3278581 tgcagcgcgt tgaaaatatc ccggctgtcc ggataaatcg tttgctccgc gtattccctc 3278641 ttcagcatct ctctgagctc ttgataatac ggtttctcaa actcttcctt tagctgattc 3278701 caccagctgt cttgtaaaag ctgtttcaag attcaggcct ccttacgaac gatgaagtct 3278761 ggaatagaca ggctcgccat cccaaaccat ttcacttttt gcttcccgcc tcttcatctc 3278821 aggctcttca agcaggacgg caaagttttt cgtcggcagc tccccgagtc cgtgcttttc 3278881 acttaaacga tccaaatatt gcttccgctt ggcgccaagg tcagcagact gattgtctcc 3278941 cgcgtcactg aaggcataaa tcacgctggc gcaagggaca cgcttcaccc ggtaatcctt 3279001 ggccgcgcgc aaataaaaat cccagtccca gtaattgtgc acatcagcat cgaaataccc 3279061 gatttcatca tgcagaaaac gtctgtacat gctgcccgac ggcacgtatg tagaaaacac 3279121 tctcatatcc tcatagtcag cggtataagc aaacaatttc cgtgacactg gataccttgt 3279181 tccgtttttc tcttcaaacg aaactatttc cgcatcagaa tgaacgaagt ctgccgtttc 3279241 tatttccttt gccattttct cgatatgccc tggcgtaaag aaatcatcgt catcacacag 3279301 cataatgcaa tccccagacg cctcttttac accggcattt ctcgcagcca catgccccga 3279361 gttcttttct aaattgatga cagcaatcgg cagctccgga taaagtgctt tgaccggcac 3279421 gaccgattcc ccggcatcat tcacaataat aatttcatac ggcatcaagg tctggcggga 3279481 aatcgactcc aaaagctcac acaaagccgg aatccgatta taggtcacaa ttacgataga 3279541 aatcttcatg atgctctcct tctcattttc atagtcatgt actattaaaa catatattgg 3279601 acgggagatc agtgggaata tcctactgaa acggcatact acaatgatag aaacagcaaa 3279661 gtggctccga tcagaagcac catgatcagc atcagatctc caaagacatg aaagatatct 3279721 ttcatgcgga cgccattcgg aaggataaga cgccacagct tagattgata gaccggcagc 3279781 agcaccagtg cataagaaag acacaaaaat gtaaaagccg gcggcacaaa agcacagcct 3279841 gcatcgtccc aattcatcat gatgtctttc atactagatc catccaataa aaacaaagat 3279901 atcatgaggg ctagcaacac aaaggacccc aattgaacct caaacaggcg cattttctgg 3279961 ttatatgcaa atcggaccgc ccaaaaccag acataagcat atgaacatag cagcgtaaga 3280021 atggcacctg ctgtaaagac gacatcaggc agccgatcaa gcagaaaaac aaaaggcaag 3280081 ctggctgcca tagccaagag catgcagcca ccagtaaaca aaaatactgc cccatgagct 3280141 acaaaaccat ataaacaaga gctaatcctc acgacataca cctcctttac atagaaattc 3280201 tatgtatata cctaaaaaat cagacaagct gacgcctgcc aatataacag cccattcggc 3280261 caaataacgg aaataacagc gttgcaaaag cacaagttcc aacaaaccaa ggtgtcaaca 3280321 aggattgaaa cagcgcagca ggaattacat tgaatagaaa aacaagcata aaaatgacgt 3280381 ttggcaccat tgagatcaga atcgtatgta gaacaagctt ttctccgcgt tttccaaact 3280441 ccttcacgcc ttgataccca atcagcaccc agtagatcat atatgcagct aagatcagcc 3280501 aaacagaaac agaaatgcct ttccatactg cttgaacaaa cggtgattca agccatacat 3280561 gcattattgt aatcgcaatg ccgacagcga atagggcact gttacagaaa agatggaaca 3280621 tcaaaaacgc acgaaacgtt actggctgta ttttcttaaa cgaagaaaca atgtcagttg 3280681 gtgttccaaa cgcctgcaat aaagtctgca tagcttcctc ctcactcttt ccttcctgaa 3280741 aagagcgaaa cagatgatgt tcaatatggc tctcaatctc ttctatcatc gcctcaccct 3280801 caggaagccc tttaagcccg cttttgattt cggatacata tgtttcttta tccattttgt 3280861 ccgctccact tcagtattcg gtccatcatg gctgaaaata cgctccattc cttcgtgcgt 3280921 tccgccagca cttctttgcc ctcgtctgta atccggtaat atttgcggtc cggtcctttc 3280981 tcctgcttct cccagtagga agaaatatac ccttggcgtt caagcttgtg aagagaagga 3281041 tacaaggtcc cttctttcat ctgcagttca tttccgctgc ggcttcccat ttcttttaca 3281101 agctcatagc cgtacatcgg ccgctcgttc agaagcgtca ataccaatat aaccgtgctt 3281161 cccttaacca gctcacgatt taacatctca aaacccctac ctagttttct tatgtagcat 3281221 tttacgaaag cccgttgaga ttgtcaaatg attcctatag atcttctata ttgtgataca 3281281 gagaaaatct aactataatg aaagacaaaa catgatggag gttcaagaca tgtctatgca 3281341 taaagcactc accattgccg gctcagattc cagcggcggt gctgggattc aagctgattt 3281401 aaaaacattt caagaaaaaa acgtatacgg gatgaccgcc ttaacggtga tcgttgcgat 3281461 ggacccaaac aacagctgga accatcaggt attcccgatc gatactgata caatccgcgc 3281521 ccagcttgca acaattacgg acggcatcgg cgtggacgcc atgaaaacag gaatgctgcc 3281581 aaccgttgac attatcgagc ttgcggcaaa aacgatcaaa gaaaaacaat taaaaaatgt 3281641 ggtaattgac ccggttatgg tttgcaaagg tgctaatgaa gtcctttatc cggagcacgc 3281701 ccaagccctg cgtgagcaat tggctccgct agccactgtc attacgccaa acttgtttga 3281761 agccagccag ctcagcggca tggatgaact aaaaacagtt gacgatatga tcgaagccgc 3281821 gaaaaaaatt cacgcactcg gcgctcaata tgtcgtcatt acaggcggag gcaaactcaa 3281881 acacgagaaa gccgttgatg ttctctatga cggagaaaca gcggaagtcc ttgaaagcga 3281941 aatgatcgat acgccttata cacatggcgc aggctgtaca ttctcagcag ccgtgacagc 3282001 ggagcttgcc aaaggtgcgg aagtcaaaga agccatttac gcagcgaaag aattcatcac 3282061 agcggccatt aaagaatcct tcccgctaaa ccagtatgtt ggtcctacga agcattctgc 3282121 actgcgcctg aatcaacaat cataaaaaaa ggggctgcct tacagagagg cagccctttt 3282181 taaatcaccg aagacttttc acagaaaaaa ctgccgatcc catcggcagc ctgtttattt 3282241 gatttttaaa ttgtttgcag atttcctcaa aaatgtttct atcgactgaa caaaaagtgc 3282301 atattccttc atttgttcat atgcccgcgt gagaatttcc gccgtttcac tgtgcggcgt 3282361 tgttccgcca agcatttttt tcagctgaag cagcacatcc ttatattctt ctcgcttatc 3282421 ttcaacttgg ttagcagcct tttccaaaca ttccggtgtt atcttctgtt catgtatatt 3282481 caagaaaaca actcctttta cagaaaaaaa tagtaggtta tcgttgaaga atagcacaga 3282541 tggctcagat ttcacataag aaaatagaag gattttctac ataagtgtcc aaattccgac 3282601 attcatttca gatttcccgg tcgcactggc tgttacttca tgatttcccg ggaaaggaaa 3282661 atatcttgca ctcaagacct cttctccgtt attgataaag atttccacag atgacgcgtc 3282721 gagaaacatg tgtacggtat gcaaatcctt gatgcggcaa tgtctcgctt ctgttctttt 3282781 tccgtcaaag ctctttcgtt ccagcgtaac aatcccctcg tctttatgga aggaaaacgt 3282841 agccgttccg cggatactga ttgaaaagcc agactccgta tgaatgtctt ccagtagaat 3282901 ctcagttctt tcaggttttt ccactggaag cgcaccagat gatccatgca tgttgatgtg 3282961 tatttttttc tcatttctgc gcatggcttt tagctcaggc agcggctgct gaatcagctt 3283021 ctgtcctgaa agcgtcagct gtctcggcag cgtcatgcag tgaatccagt ggcagtcaat 3283081 ggtcggatgg gacccttcat cctgatcagg caccgccatc catgcaaata aaatccgcct 3283141 tccctgatcg tcttcaagtg tttgcggcgc gtaaaaatca aaaccttgat caagctccgt 3283201 aaattcacca tgcttcagtt caggcttgtt ataatcgagg cggccgacaa aataacctga 3283261 ttgatatacg ttctgataac ggaaaccgtc agcctcaagc ccttgaggcg aaacaatcag 3283321 cacatccgat ccttgaaggg aaaacaaatc agggcattcc cacatgtatc caaaatcgtc 3283381 cagcccgttg aagcccgcgc cggttatcgg gccaagaaat ctccactctg tcaggttatc 3283441 agaagcaaac aacacagcct gccctttcaa attctctgtt tgcgcaccaa tcaccatata 3283501 ccatgtgcct tcatgctccc ataccttcgg atcgcgaaaa tgcgccgtat atccttccgg 3283561 aaggcgggcg acgacaccct ttttctcaaa ggacagcccg tcgtcagaaa cagcaaggca 3283621 ttgatacgtt tcccgatttc catcctgatc cctgacattt cctgtgtaaa aaagatagag 3283681 ccgatcgtct ttcgtgacag cgctgcccga gtagcagccg tttttatcaa accaatcact 3283741 cggagccagc gcaatctctt cccgcttcca attcacaaca tcctgtgtcg tataatgccc 3283801 ccaaaatttt gcgccgtgcc ccgtctgaaa cggctgccac tgaaagaata catgatagct 3283861 gcccttccaa taaatcacgc cattcgggtc attcagcagc ccaaccggcg gcatgatatg 3283921 aaaatgctgg cggtgcggat cgctgttagc gatgggctct tttttctcca cttcttcata 3283981 agcccggcga cgaagctcct ggtcatgtgc tgtcattttt tcctctcctc atcctcatta 3284041 atcttcatga caaatgctgc aatgaacgct gacactgccg caatcgccat gccaatcaga 3284101 tagtgaatca agttgctgaa gccaaacgga gccgcaatgg cgatcatcgg aattcccgtt 3284161 aacccgtaag cgtttgcagc tacatgtgta aagacgacat atgccccacc caatgcgcct 3284221 ccgatcatcg cggcgataaa cggttttcgg tagcgcagat tgactccgaa tatgacgggc 3284281 tcagtaatgc cgagaaaagc ggaaaatgct gccggaagcg cgatttcttt tgtctttgcc 3284341 tttttcgcca taaagaagac ggcaagacct gccccgccct gtgcgacatt cgccattgac 3284401 cagatcggca gcaagtagtt tttgcctata tctgcaatta gccctgcctc aatcgcatgg 3284461 aagctgtgat gaacgcctgt cagcacgatg agtgaatacg tgcccccgaa aatcagacct 3284521 gcgacaaaac cggcatggtc atatacataa gttaaagcaa ccgtaatgcc ggagccaagc 3284581 gctctgccta gagggccaat cgcgataaaa gcaacaaacc cggtgacaat cacagtaaca 3284641 aatggtgtaa caagcaaatc caccgcatgt ggaaccactt ttctcgtcca tttctctacc 3284701 ttgctcatca catacaccgc aagcaggaca gggataacag ttccctggta gccgagaaga 3284761 gcgatatcaa atccgaaaag atgcatgtaa tcaggtgtcg cttccgccaa tccccatgga 3284821 tttaaaagat tcggatgaat catgattccc ccgatgaccg ctcccaagta tggattgctg 3284881 ccaaactctt ttgaagcgct gaccccgatt agaatcggca agaaaatgaa tgctgcactt 3284941 gaaaacatat caagcagctg caaaagcgca gaatccttgc tcatccaatg aaacgcattg 3285001 atcataccca gcaatcccat taataggccg ctggctacaa tagctgggat gattggaaca 3285061 aaaatattag aaagcgtttt cgcaaatctc gcagcgggat tcagcttttc ttttgccgca 3285121 tcctgatgat tgacgtgttc ttcacgctcg atatcagctt ctttagaaaa ggcatcgaat 3285181 actttattca caaggcctgt tccgaaaatg atctggtact ggccagagct gctgaaagcc 3285241 cctttaacgc catcaagctc ttctacttgt gcttgatcta tctttgattc atctttcatc 3285301 actaaacgca gtcttgttgc acaatgagcc gcgctgataa tattttcttt ccctccgaga 3285361 agctcaatga ggcgttttgc agtctctttg taatccatct atttctcccc cttttattta 3285421 aacaaaaaag acctaaaatt cgccaacgaa taaaggacac agcgatcctt tttcatttac 3285481 gcaaatttta ggtcttgcct gctttaccag tcacaatccc gcttattcag attaagaata 3285541 cgctttcatc ataaatcatg atagcgtttt cgtcaactat ttttttagtt aaatagtttg 3285601 atataacatg tagacaaaaa ttcgtaaaaa ttaattgtga aatacttcac aatatcgtgc 3285661 tatactatgc tcaatcatga aagaaagcag gaaaagacaa tggaaactca agcattacaa 3285721 aaggttgaac agtatgcttt gaaaaaacaa aacatattcg cttcaagcaa aatccgttat 3285781 gtgcttcggt ccattttggc cagtatattt attggttttg gcattacagc cgcaagcaaa 3285841 acaggcagct atttctttat ggctgattct ccgtttgcct ttccggcagc cgctgtcact 3285901 ttcggggccg ctattctgat gattgcttac ggaggcggag atttatttac cggcaacacc 3285961 ttttatttca cctataccgc gctccggaaa aaaatcagct ggcgcgacac cctatacttg 3286021 tggatgtcaa gctatgccgg caatttaatc ggcgccattc tgtttgccat cctgatcagc 3286081 gcgacgggac tttttgagga gccttctgtt cattcctttt tgattcattt ggcagagcac 3286141 aaaatggagc cgccggcttc cgaattgttt ttcagaggaa tgctgtgcaa ttggcttgtg 3286201 tgcctcgcct ttttcattcc aatgtctctc aaaggggaag gagcaaagct ttttaccatg 3286261 atgcttttcg ttttctgctt ctttatttcc ggctttgaac acagcattgc caatatgtgc 3286321 acattcgcca tctcgctttt gatcgagcac cctgatacag tgacactgat gggagcagtc 3286381 agaaacttaa tccccgttac gctcggcaat ctgaccgcgg gaatagttat gatgggctgg 3286441 atgtactaca cactgaatcc tgatcaataa aaaaacttcc agagatcact ccctgcaagt 3286501 caaagcggtt attccgagag atcttgaaga cgctggacat gcagcgtgat atagccggcc 3286561 tcggattccg gcaaatgtaa ttgatattca tttttcaaaa actccgccag ctccagcgca 3286621 cattgatagg cgaatgaata ctttttttgg atgaaataaa gcatctcctc gtccatacga 3286681 tggagcgctt catttgattc caaccggctg accgcgtatc gcaaatgcgt gacaaggcgt 3286741 tgataggaaa tgctgttttc atccaccttt cgattaaagt attgttttat tttctctatc 3286801 atttctttga tcatggtcgt atgcttcagc gctgaataca tgctctccgc atccatcttc 3286861 gccgtatgga tgtgaagggc aatataaccc gcttcatctt caggcagaga cacgcccaat 3286921 gtctctttta catgtccgat cgcccacagg ccgatctcat attctttttt atagagcgcc 3286981 tttatctcat gcagcaattt attctgcaca agcagcccat tttgaatcct ttcgatcgca 3287041 aaggacaaat ggtcggaaag cgcgatatga atgtgatcgc tcagcggcgc cgcgagctct 3287101 ccttccgcat agctgatgat atcctcagct atttctatat gctcctccgg cagtgtttgc 3287161 aggatttgtt tgaacttttc attctcgtcg cgcacgacaa agatcttttc cactttattc 3287221 atagggatga gatcattttt ctttttttga aaagcgattc ccggtcccat cacgattttt 3287281 tcctgatcat cctcttttat taaagccgca ttgttgttta atactttata gattttcaag 3287341 aggttatctc tcccgccaat ttgcttttga ctgggatttt acctcctttt gaccgccatg 3287401 taaagatgcg ggcccgctct ctcctgcttt ggcgattcct tgaaggcttg caaacatctt 3287461 cttttataaa gcgcggcggc tttcgctttc tgcttttctt cctcattcac agccatccgc 3287521 cattcataaa acgaaacgag tcctgcggcc tgcacagccg cctttctttg gtatgtacgc 3287581 tgagccgaat agaccgcggc agccgcagtt tttctgtccg gcgtcaccca gttcatcaaa 3287641 aagaccatcc acacccgtaa agatacaagc aaacgtttca tagaaaaaca tccctccgct 3287701 tctttttggc aggcagcctt tttagcagcc cgttttctca gccgcagccc gcaagaaaag 3287761 acggccgatt tcttttctcg caaactagcg gctctagcaa aactcatgac tctatgatag 3287821 accgtggaaa gagaattctt tgtcacaata tgagtgaaaa aaccaactag tttttagaag 3287881 ttttgttgaa agctgaaaga attgaaatga aaattggaga accgctttga aaactttata 3287941 cacaagttat cccaaagata agaacaactt aatcacaaga gatatccaca tgtccacaaa 3288001 ctctatctat attttgtata cgaacgtata ttcctaacta tatatataca caggtttatt 3288061 cacttataca cagggttctg tgtataactc cttcgttata cacaaacaaa atccaataaa 3288121 tggtccaaat gacacaagga tttttttgaa ttttcaagaa atatatacta gatctttcac 3288181 attttttcta aatacaaagg gggaaacaca ttgaaaaagg ggatcattcg ctttctgctt 3288241 gtaagtttcg tcttattttt tgcgttatcc acaggcatta cgggcgttca ggcagctccg 3288301 gcttcttcaa aaacgtcggc tgatctggaa aaagccgagg tattcggtga tatcgatatg 3288361 acgacaagca aaaaaacaac cgttatagtg gaattaaaag aaaaatcctt ggcagaagcg 3288421 aaggaagcgg gagaaagcca atcgaaaagc aagctgaaaa ccgctcgcac caaagcaaaa 3288481 aacaaagcaa tcaaagcagt gaaaaacgga aaagtaaacc gggaatatga gcaggtattc 3288541 tcaggcttct ctatgaagct tccagctaat gagattccaa aacttctagc ggtaaaagac 3288601 gttaaggcag tgtacccgaa cgtcacatat aaaacagaca atatgaagga taaagacgtc 3288661 acaatctccg aagacgccgt atctccgcaa atggatgaca gtgcgcctta tatcggagca 3288721 aacgatgcat gggatttagg ctacacagga aaaggcatca aggtggcgat tattgacact 3288781 ggggttgaat acaatcaccc agatctgaag aaaaactttg gacaatataa aggatacgat 3288841 tttgtggaca atgattacga tccaaaagaa acaccaaccg gcgatccgag gggcgaggca 3288901 actgaccatg gcacacacgt agccggaact gtggctgcaa acggaacgat taaaggcgta 3288961 gcgcctgatg ccacacttct tgcttatcgt gtgttagggc ctggcggaag cggcacaacg 3289021 gaaaacgtca tcgcgggcgt ggaacgtgca gtgcaggacg gggcagatgt gatgaacctg 3289081 tctctcggaa actctttaaa caacccggac tgggcgacaa gcacagcgct tgactgggcc 3289141 atgtcagaag gcgttgtcgc tgttacctca aacggcaaca gcggaccgaa cggctggaca 3289201 gtcggatcgc cgggcacatc aagagaagcg atttctgtcg gtgcgactca gctgccgctc 3289261 aatgaatacg ccgtcacttt cggctcctac tcttcagcaa aagtgatggg ctacaacaaa 3289321 gaggacgacg tcaaagcgct caataacaaa gaagttgagc ttgtcgaagc gggaatcggc 3289381 gaagcaaagg attttgaagg gaaagacctg acaggcaaag tcgccgttgt caaacgaggc 3289441 agcattgcat ttgtggataa agcggataac gctaaaaaag ccggtgcaat cggcatggtt 3289501 gtgtataaca acctctctgg agaaattgaa gccaatgtgc caggcatgtc tgtcccaacg 3289561 attaagcttt cattagaaga cggcgaaaaa ctcgtcagcg ccctgaaagc tggtgagaca 3289621 aaaacaacat tcaagttgac ggtctcaaaa gcgctcggtg aacaagtcgc tgatttctca 3289681 tcacgcggcc ctgttatgga tacgtggatg attaagcctg atatttccgc gccaggggtc 3289741 aatatcgtga gcacgatccc aacacacgat cctgaccatc catacggcta cggatcaaaa 3289801 caaggaacaa gcatggcatc gcctcatatt gccggagcgg ttgccgttat taaacaagcc 3289861 aaaccaaagt ggagcgttga acagattaaa gccgccatca tgaataccgc tgtcacttta 3289921 aaggatagcg atggggaagt atatccgcat aacgctcaag gcgcaggcag cgcaagaatt 3289981 atgaacgcaa tcaaagccga ttcgctcgtc tcacctggaa gctattcata cggcacgttc 3290041 ttgaaggaaa acggaaacga aacaaaaaat gaaacgttta cgattgaaaa tcaatcttcc 3290101 attagaaagt catacacact tgaatactca tttaatggca gcggcatttc cacatccggc 3290161 acaagccgtg ttgtgattcc ggcacatcaa accgggaaag ccactgcaaa agtaaaggtc 3290221 aatacgaaga aaacaaaagc tggcacctat gaaggaacgg ttatcgtcag agaaggcgga 3290281 aaaacggtcg ctaaggtacc tacattgctg attgtgaaag agcccgatta tccgagagtc 3290341 acatctgtct ctgtcagcga agggtctgta caaggtacct atcaaattga aacctacctt 3290401 cctgcgggag cggaagagct ggcgttcctc gtctatgaca gcaaccttga tttcgcaggc 3290461 caagccggca tttataaaaa ccaagataaa ggttaccagt actttgactg ggacggcacg 3290521 attaatggcg gaaccaaact tccggccgga gagtattact tgctcgcata tgccgcgaac 3290581 aaaggcaagt caagccaggt tttgaccgaa gaacctttca ctgttgaata agaaaaagcc 3290641 ctgccgattc ggcagggctt tttaaagatc agtcagcaaa cgcctcctgc aataagcgat 3290701 acgatcggag cttatcttca aaatgatgcg tgatggtcac caccatgatt tcctctgttt 3290761 catacgcgtt actcaaagct aacagccgct ccttaacctg ttctttcgta ccaacaatca 3290821 ttcgatttcg attatcagca attcgtctct gttcataagg agaatacgta tttttccgaa 3290881 cagcttcata cgaaggaact ccctctaaag gaataccctg ctctcccgcc aaaagtgtaa 3290941 aatcaagcac agccccaagc tcctctgcct tctcctccgt gtcagcacaa agaacaaaaa 3291001 cagcaactgc cgctcgaggc gtatctccta acacagacgg tttgaatcgc ctcttatact 3291061 gtctgacagt accctctccg ccctctccat tgataaaatg ggcaaacata tagccagcgc 3291121 cagattcagc tgcgagcagc gcgctttctc cagatgagcc gagcagccac acatccggag 3291181 ccgttgaaat atgcggcgca gcggtcagat tcggaaaacg gtgtttgtca tccgccaaat 3291241 catgcaaata catggtcagc tccttaattt gctgcggata ctgatcagca ttgcgcttac 3291301 caccgtcatt cagcgcccat gatgcaatcg gcattccccc cggtgctctg ccaagcccca 3291361 ggtcaattct tcctggtgtc agcccctcca gaacacgaaa gttttcagct actttataag 3291421 cactgtaatg cggcagcatg actcctcctg atccaacacg aattcgcttt gttttcgctg 3291481 ctatatgact gattagcacc tcaggactgg accctgccag ccgttttgaa aagtgatgct 3291541 cagaaaccca aaatctctta tatccaaggt cctcagcagc ttgggcaagc gcaacggttt 3291601 gctgtaaggc cgtttctgca ttgctgccct ctgatactgg agattgatct aatatactta 3291661 atgaaaccat ccctaccacc tcatcctcat cgtatcactg atcccctatt ttttctccaa 3291721 agccgctcac actgcttatc agtgtcccct atcattcgcc atttatttgt gaaagcatgt 3291781 ccctatttgt cggaatatgt tacacgtgaa acataaaaac ccctccagac ggagaggttt 3291841 gctttagttt ttattaaagc ccttttcttt cacgtagtca tttaaatacg tacgcggctt 3291901 ttgcttcata aagttcagta tttgatcgga ccacgtttct tcccgcttcc cgtttgttct 3291961 ttctctatag taatcagaaa tggttttgtc atacgtattc atagtatgac ggaaatcgtc 3292021 tgtgttcaca ttatacgtat tttcatgata aacggcctgc tttggcaatc tcggtttttt 3292081 gccggaaagg ttcgcaggat ggcctactgc cagtccgaaa agcgggagca catggtcagg 3292141 cgtttgcagc acctctgtca ccttgtccaa ttcattccga atgccgccga tatagcaaat 3292201 gccaagcccc atggattcag cggcaatgct catattttgc gctgccagcg ccgcatcaat 3292261 caagctaacc ataaacattt ctgtattctc gagcagctca gaaatatgtt cacctttttc 3292321 ctcagccagt tgttgatggc ggtacaaatc cgcacaaaat acaaaaaagt gtccgttctt 3292381 ctcaacgtaa ggctgattcc cagcaagcac ggacagctca cgttttttct caggatcaga 3292441 aaccccgata atcgaatatg cctgcacata gctggatgta gacgcagcct gcgcactttt 3292501 cactaatgta tcaatttctt cagctgtcaa aagctgatca gtaaaagacc ggattgaccg 3292561 atgattcaaa atggtttcga ttgtgttatt catcacaaaa acctccttat cactttttat 3292621 catatccgaa aaaaagtgat ctcaaaagtg aaatgctctg cacaaaaaaa gacagcctct 3292681 gtaaaggctg tctgcatatc aagaattaaa aagataactt ctgtatttcg tcagctgcac 3292741 acttgcatta tatacaatcc caaatccgat taacgtggaa agtgtcgagc ttcccccata 3292801 gctgacaaac agcagcggaa tcccggtaac aggcataatg ccaatgttca ttccgatatt 3292861 ctggaatgtg tggatcacaa ttaacgccgt atagccaacg caaaagaaag aagcgaaacg 3292921 gttaaacgga tgtattttgt ctatcagaac aacaagcctg tagattaaaa agaagaacat 3292981 gatgacaaca attgcacagc ctataaagcc aaatgactca cctattatag aaaagataaa 3293041 gtcagtcgta ctctctggaa cataaacctt caaattagaa ataccattac ctaaaatacc 3293101 accagatcct attgccatga tggcctggtc aacttgccag ctgtcatttg aatcttcctg 3293161 tgtctcattt gaagcagaca cccaagaagt gacccgctta atttgataat cctgtattcc 3293221 aactgattta gcaacgtcag gaaagtttat cattactaat aaaattaatg aaatgagtaa 3293281 gatacctgaa ccagctatga tcgcaatcaa tttccaattt atccctgaca taaaaaccat 3293341 tacaagaacg ataaacatac atattcccgc agtcccagca tcctgcatca ggataagacc 3293401 tacaggaata actgcgacac ccgcaatctt taataacaag tggatatcat ccctaagcgt 3293461 ccgaactcct ttaggatttg cttttccaat aactgaagca agcatcataa tcaaaccaac 3293521 cttcataaac tctgacggct gtattgttat tctaccgatc ctaaaccaac tttttgcccc 3293581 tttaataaca ggtgcaatag actcgggact gattttaaga ataatcaaag ataaaatacc 3293641 aatgataaaa atatataaac ttaacttttc aagctgttct aaatcaaagt acaaaagaac 3293701 tgtaatggct acagccccca aaagataaaa cacaatttgc tgaatccaat ccgtgttccc 3293761 atactgccca aactgaccgg cagcatatat tgatactacg cttataataa aaaacacacc 3293821 aaatataaaa atcaaatccc cctggtaaaa ggggctttgc tgtttcttat atcgactcat 3293881 tctatcccgc cttacatttt catcggaaaa tcactaatgt ttattataca tgaaccacgt 3293941 tcaagatgac acgtgaagct cgcttccttt tatgtttttt cagcatttgc ggcgcttttt 3294001 cagctacacg aaatatgacg tatcataaac cgaaatgttt cgattgacac aaaacttttc 3294061 aaatgaaaaa aacgccatac caatagaatt tgttaaaaaa cgaatgcgat aatgtgttat 3294121 gttcccaaat aatgtgatac ctcatataga aatagctaaa aattcagagc cccatgccca 3294181 tacattctcc tagcacatta aacgaaaaaa taagacgata gatccagtcc atttctgcaa 3294241 aaacacgtat caatttctgg aaaacatggt ataataattg taacagaatg ttcaaaaaac 3294301 aatcacaaaa cagacacaac tcagttcctc tatttcattt ttgtaaacgt tatcacaaaa 3294361 tgaaaggaga cgggtatgat ggacatgttt tttgcttact tattggttgc cagcgcaacg 3294421 cctctcttta tttggcttga taacaaaaaa gtcgcactct cagctattcc gccaatcatt 3294481 ttaatgtggg tattcttctt cttttacgca acagaaagcc tttctccact tggacacact 3294541 ctcatgatta tcttgtttgc cgttaacgtc attgtcgctc atatcgccgc atttatcatt 3294601 tacggccttc cgtatcttcg cagaaagcga agcagctgaa gacagcaaaa aaccctcttc 3294661 cactgaagag ggttttttgt attattcgtt atggcctgaa tgctctgagt gttcagcgcc 3294721 tccaggagga tttccgtcca tatggtcacc atggtgatag tgagccgcga aaatccagat 3294781 ggatccaagt acgataacga tcgcgccaaa gaatccgaac agcgtgtttc cgacttggat 3294841 cgtgccgttt tcgctctctg tcatatgcat gaacatgaga agctgcagcg ccgcctgaat 3294901 gaaggcgaag ccgaagataa tccaaagttt tgctgatgag ctcaggtcag tatacactgc 3294961 aacccataga gccagcaggg tcaaaacgat agacaggata aaacctacaa tgtgtttcca 3295021 tggaaagtga ctgtgttcag cagatttgtt tgccatttta cagacccccc aatcccatga 3295081 gatagacacc tgtaaagatg aaaatccata caacatctaa gaagtgccag tacaagcttg 3295141 agataaagat tttagatgaa gtttgcggag ttaagccgcg tttcttcaac tgaatcagaa 3295201 ttcctgtgat ccagaaaatc ccgattgtta cgtgagttcc gtgagttcca agtaaaacaa 3295261 agaatccaga ccagaacgca cttgtactga gagccgctcc ttcatgtaca tagtgaacaa 3295321 actcgttgat ctcgcatccg acgaagccgg caccgagaag aagagtgata attgtccaaa 3295381 tgactacgcc ttttaaactt ccgcggcgca tttcatgaac agcgatcccg caggtaaagc 3295441 tgctgatcag cagcaagaac gtcataatca ttaccagatt gacttcaaat agttcgtctg 3295501 gcaagacacc tccagctgtt ctgtttttaa gaacgaagaa ggttgcaaat agtgttgaga 3295561 acaacacaat ttctgcccct aaaaagatcc aaaacccgag aatattaagt ctgccggttt 3295621 cagattgata ttccataggc gcgttagaat tgccgtgttc tgcatgttcc ataactcacg 3295681 cctccttatt cggaaatctt tctttccgtc tcttttattt catcaacact aatgtagtag 3295741 ccgttgtcgt attcgaatga acgcagaacc atgcagagca ggactccgat caatccgact 3295801 acgcccatcc agtaccattc aaagacaagt ccaaagcctg cgagaccgaa ggcaacagac 3295861 ataaagaacg gtctgcctga gttgcttggc atatggattt tcttgaattt gctttcaggg 3295921 tataattcag ttttttcttc tttcatatgc aggaatgcat cttgagattt gacttcagga 3295981 agcaccgcaa agttgtaatg cggcggaatc gcagaagaag tcgcccaatc aagcgtacgt 3296041 cccacacccc atgaatctcc gctgatttca cgagtagagt aacggaagct gtagtagatg 3296101 ttatagcaaa ggattaagaa tcctacaccc atcatgaaag ctccgactgt tgagataaag 3296161 ttcaatgttg tccagccgtc attcggtccg tatgtgtaaa tacggcgcgg catgccttga 3296221 agccccaaga aatattgcgg gaagaaacaa atattgaacc cgatcataaa gatccagaag 3296281 aaccattttc cgattctttc gttcagcttg tggccgaaca tttttggata ccagaaaata 3296341 aatccggcga aacaagcaaa tacagtaccc gcaatcagca catagtggaa gtgagataca 3296401 aggaagtacg tattatggta ttgataatcc gctgctgcca tcgcaagcat aacccctgta 3296461 accccgccga taacgaagtt aggaatgaac gcaagcgccc acagcatagg tgttgtaaag 3296521 ctgattcggc ctttatacat tgtaaagagc cagttaaaga ttttaacccc ggttgggatt 3296581 gagattgcca ttgtcgtaat tgagaagaat gagttaacgg acgcactgtt ccccattgtg 3296641 aagaagtggt gagtccaaac taagaaactc aatacagaga tggcgataat agaaccaacc 3296701 atcgctttgt aaccaaacaa ttgttttctt gcaaagcttg agatgatttc tgagaaaata 3296761 ccaaacgccg gaagaataac gatatatact tcaggatgtc cccaaatcca gaacaagtta 3296821 gcccaaagca tcggcatacc gcctgcttcc aatgtgaaaa agtgagcgcc gaacaaacga 3296881 tcaaatgata aaagtgctaa tgctactgta agtacaggga acgcaaacac gataataacc 3296941 attgtgatca gtgttgtcca tgtgaacatc ggcatacgca ttaatgtcat gccttttgtt 3297001 ctcattttta agattgttac cataaagttg atccctgtca tcagggtacc gataccggca 3297061 atctgaagtc cgaggaggta gtagttctca cccggcccag ggctcatgtc gttacttgca 3297121 agcggcatat aactcgtcca gcctgcgttc ggagaacctc cgataacgaa agaaatattg 3297181 aaaagcatcg cccctacaaa gaacgtccag aagctcaggt tgttcaagta agggaacgca 3297241 acgtcgcggg caccgatttg aagaggcaca acaacgttga taagaccgat taagaacggc 3297301 atcgccatga agatgatcat gattgtaccg tgagttgtaa aaatttcatt atagtggttt 3297361 gagtctaaaa aactgttatt cggaagcgct agctgggcac gcatcatcag accgtcgaca 3297421 ccgccacgga ataacataat tacagcagat ataatataca tgattccgag ttttttatgg 3297481 tcaacagtag ttatccattc agaccacagc catttccact ttttgaagta agtcagaaca 3297541 aaaataatgg caatggttga aagcgcaatg gaaacttgtg cgcccagaat taatgggtca 3297601 ccagttacga aaaattcgtc ccatttgaat ttcatgcagg cttcctcctt tcctgatcaa 3297661 tatcattctt ctgtatcatc agacttctta aattcgtttt tctttacgtt ttcaaacgga 3297721 tctgttttag aatgcggtga aacggcttga tagccaaggc gtttgcgcgc ctccatcgcg 3297781 tactcagcgt cttgtccgtg atcaacgtat ttcaagtgag tagaagagaa cgttaattcg 3297841 tccacatttt caggaagcat caattcatca tacttctctt ttgtcagctt aggagcctcg 3297901 ttctgagtct ttttcaccca gctgttaaag tctttttctg tgactgcatt cacatcaaac 3297961 tcttggtctg caaaatgttc acctgtgaag ttcgcgttgc ggccttcgta agtacccact 3298021 ttgtcagcct gtaagtattg atccatcagc attcctgcca tcgcatattt ttgccctcca 3298081 agctgaggaa tccatagcga agccattgaa tctgcagatg agattttgaa caagatcggg 3298141 cggtcgacag gaatgtttaa gtagttgacc gtttcaatat cctgttcagg gtagctaaat 3298201 acccatttcc agtctaccga agtagcataa acaacaagag gctctttgtc ttttgttgct 3298261 tcaggagctt tttctaacga atatatcgtc tgtactgttg gcacagaaag tgcaatgacg 3298321 attaaaattg ggatcactgt ccagactact tctaaaaacg tgttaccgtg aatttctggg 3298381 ttataagatc cattatcttt gcctttacgg tcgcggtatt ttactaaaat aatggtaaat 3298441 agaacaaaga cgaccccgac gataaacagc ataaatccga tagataacag gattaaatca 3298501 ctttgctgtt cagctacagg tcctttcgga tctagtactg aagcattgct gcatccccca 3298561 aggacgaaaa ccacagttaa cagcgctaat acaagcaacg gttttaatgc tctgaacaag 3298621 aagatcacca tccttcctat tgatgtaata aatctgaagt gcatacttcc tcaaaatctt 3298681 ttctctactt tgttatgcta tcaaaaactt cacttattag ctttattttt ttataaactt 3298741 catcccattt tcgcttaaat gtcataaaat cgacaaaaat tgctccaact ttattcacat 3298801 ctatcgctta agatgaaaag tttctagtta tttccgcata taaagtaaag aaagatgatg 3298861 aagaactaat tctgacaaat taaggtttac cacaataaaa aacttaggtc aatcaaaaat 3298921 ttcattttgt taaactttct agataggaat tattttttcc tcgtctagca tcttttcaca 3298981 cggttaccat tttaacgcat caaatattga aagaaaaggc gcaatgaaga gccaatatgc 3299041 tctgaattgt ccgtattttt ttatgagagc atccagttgt ttatcttata caaaaaagag 3299101 gaatgatata agcaaataaa taaaaaatag gatgtgttgc atgatgagtt ttcttatttc 3299161 acttatcgtc gctattatta tcggatggct tggaagcctg tttgtaaaag gagatatgcc 3299221 cggaggaatt atcgggtcta tgatcgcagg tcttataggc gcctggatcg gacacgggct 3299281 gcttggaaca tgggggccgc acctagccgg atttgccatt attccagcgg taatcggcgc 3299341 agccattgtt gtctttctag taagcctgtt aaccagaaaa agaggataaa agcagcagca 3299401 cccgaagcgt cagcgctttg ggtgtttgtt ttgccataaa aatcgaaaaa gcctcaaccc 3299461 tagcggttga ggcttttgac tggtttggcg cccaactgat cgatgaacct tctgaaggcc 3299521 tgttttccct ctgctgtctg cttaaataca ccggcgtgtt caaggatgcg cgcgaataca 3299581 tgtcccagct cttcttttat gactagatct acgttctctt ttgttatggt tcttttttcc 3299641 atcgtccgaa gagcccactc actatgcttt gcagtgagcg gattttgttc taaggctgtt 3299701 ttcggatcag cagaacatag cgccgctgcc gtttctttca tttcctcctg taagcggcca 3299761 ggcaatatcg ccaatcccat gacctcaatc aggccgatat tttctttttt aatatggtgg 3299821 acttcttgat gaggatgaaa tattcctaat ggatgctcct catccgtccg gttgttcctc 3299881 agtacgatat cgagttcgta caagtctccc ctgcgccgcg caatcggtgt gaccgtatta 3299941 tggggcgtat cgcctgtata ggcggcaatg ccggcttttt catcggaata cgtctgccac 3300001 gtgcggaaga tatggtcagc agcttcggcg acatgacccg gttcgtctcc ttggagcctg 3300061 agcacagaca tcggccactt cactaagccc agcgacacgc cgggataatc atttaattca 3300121 taaacgtctt ccgcttctgc acgtgccatt ggaaaatcat gcgcgccgcc ttggaaatga 3300181 tcatggctta ggatgctgcc gccgacaatc ggcagatccg cgtttgaacc gataaaataa 3300241 tgcggatatt ggccaagaaa tgacagcagc ctttcaaatg tttttttgct gatctccatc 3300301 ggttcatgtt caccttttaa gacaatgcag tgctccggat aatagacata tggcgagaat 3300361 tgcaggaacc attgttcgtc ctcaaggatg accggaatga ttctgtgatt ttgccgggct 3300421 ggatgattca cgcttccctc gaagccgaca ttttctttac acagcaaaca catcggataa 3300481 tttgtctgtt cctgctcttt tgcagccgca atcgctttcg ggtccttttc aggctttgat 3300541 aggttaatgg tcatttccag ctcgccatat tcggtcggca ccgtccaatg aacatttttg 3300601 gcgattctgt cagtccgtat ataatagaca tcctctgaat attgatagaa ttcctttgtc 3300661 gcctgttttg ggccgtataa tgcttttgtc tcttcaaatt tgcgaatgac ctcggacggg 3300721 gcaggcacaa aacagcccat cagctttgcg ctgagcaggt cacggtacgt atctgtatcc 3300781 gcttccattc ggccggtttc ggcagcccat ttatagatgg gagctagcaa gtccggcagg 3300841 ctttgtgact gcttgatgct ggtgctggag ttcggctcgg gatgtgtgat gcccagcgct 3300901 tcataaagac ggtttctcgt atattcccga tcccagatcg aaatcaattt tcgttccagg 3300961 ccatactcaa gcagctgttc cagatgttca ataatactca tatgtcactc cccctttagt 3301021 tctctcgctc cctctccgat atccgcgaca taaaagtccg ctcggagccc tgttttttct 3301081 tgatatctgt ctccaacctt ctgaataaaa tcatcaacga actcatcttt tacaatgctg 3301141 atggtgcagc cgccaaagcc tgctcccgtc attcttgatc caattacacc ttcgtgatcc 3301201 catgccgcaa acacaagctc atcaagttca gggcatgtta cttcatagtc atccttcaat 3301261 gaaaggtggg attccttcat taactgcccg atttcatcta tattgttctc tttgaacata 3301321 tgggccgtct taatagcacg atgattttcg tatacagcgt gctttgcccg gcgtctgttc 3301381 gtttcatttt ggatcaggct ggaatgcgca tcgaaatcag aaggcttgat gtcgcccagt 3301441 gcggcaatat cgaggccttt tttcagatca agcaatgcat cattgcattc ttggcgtctc 3301501 gtattatagc tggagtcagc caatgtcctt tttttgttcg tgttcgcgat gaccagcgcg 3301561 aggcctgaga cattgagttt gctatattca tagtcaagcg tgtcacagtt cagcagcatc 3301621 gcatgatgtt ttttccccat tccaattgca aattggtcca taattccgca attgacgccg 3301681 ataaaatggt tttccgcatg ctgcgccatt ttcacaagct caagcgcatc tacttcagga 3301741 tgaaaataac tttggagcac gacccccatc agcagttcaa tagaagcgga agacgacagt 3301801 cccgccccgt ttggaatatt ccctgaaaat acaatgtcaa agccatgggg aactgcatat 3301861 cccctctgtt gaaattcata aatcacgcct tttgggtagt tcgcccagtc gtcttctttt 3301921 tgatagcgaa tgtcgtcaag gctgcattcc ttgatgcctg cgtttctaaa gttatctgaa 3301981 tacatccgga caagcccgtc gtttctttct gcaacagcag catatgtacc cattgtcagc 3302041 gcgcacggaa agacatgccc gccgttatag tctgtatgtt ctccaatcag attcactctt 3302101 ccaggtgcga aaaaaaaccg taacccctct ttttctccga atacacttgc aaatatcccc 3302161 tttagctctt cccgcatgtg caatcacctt tctggttttt attttttatt ccccttattt 3302221 cttcatagaa aacggcagat catatgctgc agtcctctca taccccttct tcttttgttt 3302281 ttttaaagac gagccatttg ctcgcaacat agttgacgac aacaatgacc gcgttgtcga 3302341 gtattttggc caaggtttca tttgtattga actggccgac aagaatgatc atcatgccta 3302401 aatctatgcc gagagacagg acccgaacgc tgaaaaaagc agtgagctct ttcagcaggc 3302461 tctgcagatc atgtgttttt tgctgaaaca catataattt atttgttatg taagcaaaca 3302521 gcacggacaa aatccaagcg gcaacagtgg cggctttgta atccacattc atgatctcta 3302581 ccaatatata aaagctggcg atattcacaa tggttgtgaa aacccccata atgatataca 3302641 taattatttc tctatacttc actgatgttc ctcgctttct gaaaaacttt tcaaaattct 3302701 tggcctctcg tgctctctgt ctaaagtaaa aaataccgag agtgcgtcta aaaagctgcg 3302761 gaaggtggct ggctggccca atacatatga ttgtttgatg attccgtcga ggactgcaca 3302821 tattatttta gccgtatatt caggatcaat acaggcgtca atcagctttc tctccttcag 3302881 ccacttaata tataacacat tttcttccac ccacaattcg tacagccgga cataggcctt 3302941 gcatttcttt aagactttat atgtcggcat gttcatggca aacgaggtga tgtcccacga 3303001 cggcttattt atgtaatagg aataaagcag ttctgcagcg tgttttgcag cctcgtccaa 3303061 tgtcagcgat ttcactgact cccgctccat ttgatcaaga taccctataa tgatcttttt 3303121 tttcatctga cgtttttcga gaaggtacag cagaaaatcg tccttgctga caaaatgaac 3303181 ataaaatgct cctttgctgt acccggcggc tctgctgata tcttctacag aaaccggatc 3303241 atacgctcgg tcaatcaaca aattcacgcc agcgtctata aaactttcaa atgttgcttc 3303301 tcttttaatt tgaaatttgt tttttttcat atttttctcc tggcggtaat gattaccctt 3303361 atcttacacc ggatcaatct ttagcggtat ttatttcttt aaacggttat gctattcggt 3303421 ttcccagggg tcatttttaa taggctaaat gatttatttt catttacata ctatccagtc 3303481 agtatttaat tgtttattat tataaataag gtccattggt tatattagtc atttttttag 3303541 ggaataggta ggtggttttt ccttcagttt gtgaacaccg agcaactatg tgtgaaattt 3303601 gttgtactcg cctccatcat cgcgctggct tgtcttttat tgcccgcatg ttgcaggaaa 3303661 acattttata caattggagg ttactatgaa aactcatgtt aaaaaagatt tggacaaagg 3303721 ttggcatatg ttaattcaag aagctagatc cattggatta ggcattcatg atgtgaggca 3303781 gtttttagaa tctgagacag catcaagaaa gaaaaaccac aaaaaaaccg tccggcaaga 3303841 ctagtccgaa caggcggatc tatttacctc tggcttttct atcacctgat ctgagttttc 3303901 accatatcct ctattcaaaa gcaaatcgct gcgctgagct tgaggacaaa cggtgtgtca 3303961 gctaactacg acagacagcc ggtgatgcga tcacctcttg gcacatgcat tgtcataaag 3304021 aggtgatgcg aacatgataa ccgtgctctg gtaaacagca gctttgctga gaacaagctg 3304081 cattcggtga ggttttgaaa gcaaactcgt ttatacacgg ccgagcttga aaaccttcgc 3304141 ctgtctttag accactgtgt tcacctcttc acgacttcct tcttttttca tcctccagct 3304201 attgtacaac gcataaatcg gactttcagt acatacctat tggtgtacct ttttgcttac 3304261 gtttagcgaa taaaaggagg aaagccatgt acaaagctga ttataaacag attgctgcaa 3304321 cgccgtcttt tcaagctttt ttaaagcaga aacgcgcttt tattgttcct tctgcgattt 3304381 tcttttttgt tttttatttt tcactccctg ttttgacatc ttatttcacc tttttgaatg 3304441 caccggccat tggagctgtt tcatgggctt ggctgttcgc catcgcccaa ttcgctatga 3304501 cctggatact gagtactgtg tattcccgga gagccgccca tttcgataag tatgtaagcg 3304561 ctttaaaaga ggatctgaag ggtgaacaga catgaatatg actgcttttt tattattttt 3304621 ggcgattgtt ggcctgacgc ttattatcac gtattttgcc gcgaagcgga cgaaaacgac 3304681 gagtgagttt tatacggcgg gcggcgggct caccggcgtt cagaatggac tggcaattgc 3304741 cggtgactac atgtctgccg cctcgtttct cgggattgcc ggaatgattg cgttatatgg 3304801 atttgatggc ttcttttaca gcatcggttt tctggtggct tatctcgttg tcttgtacat 3304861 cgtggcggag ccgcttcgga atcttggaaa gtacacgatg gcagacatga ttgccgctcg 3304921 ctttaaagaa aagaaaatcc gcggtgtcgc ggctctcaat accattgcca tctctacttt 3304981 ttatatgatc gcccagctcg tgggggcggg cgcgctgatc aaactgcttc tagggctgga 3305041 ttataccgcg gctgtcctca tcgtcggagt gctgatgacc atttatgtcg tgtttggcgg 3305101 catgatcgcg acaagctggg ttcaaattat taaagctgtt ttgctgatgg ccggcacact 3305161 cgtgatttcg attatcgtgt tttcgaaatt cggctttagc cttaatacca tgtttgaaca 3305221 gatgaaaacg gctactccgc ttggcgctga ttttttgaac cccggaaata aatacaaggt 3305281 gccgcttgag accttgtcgt taaacttggc actcgtgctg ggaaccgccg ggcttccgca 3305341 tatattgatc cggttttata ccgttaagga tgccaagacg gcccgtacat ccgttgtgtc 3305401 agcgacatgg attatcggtg tgttttacat tatgacggta tttctcggct ttggtgccgc 3305461 ggcatttgtc ggttttgacg cgattacggc ggctgatcaa gcgggaaata tggcggctcc 3305521 gcttttagca aaagcgctcg gaggagactt tctgttcgcg tttgtatcag ccatcgcctt 3305581 tgccaccatt ttggctgtcg tgacagggtt ggtgctgtct gccgcctcag catttgccca 3305641 tgatatttac agccagatca tcagaaaggg agaagcaact gaaaaagaac aaatgaaagc 3305701 ggccagatgg gcttctgtcg ccgtgtcagt gctctcgatt ctccttgcga tttttgcaca 3305761 atccttaaat gtggcgttcc ttgttgcact cgcgtttgcg gtagccgcca gcgcaaacct 3305821 tccgctgatt gtgtttacag tcttctggaa acgattcaat gcctcaggcg ctttatgggg 3305881 cagcctgaca ggcctgatca gcgcgcttgt gctggtatcg atgagcccta gtgtgtggga 3305941 cccggccgga ggtgctattt ttaccggtga tccgctcatt ccgctatcta atccaggaat 3306001 tatttccatc ccgctcggct ttctcggcgc gtggctcgga acggtgctgt cgtctgataa 3306061 aacaattgat gaagatacgt ttgcagaaat tcaggtgaag gcgcatactg gcgtccatat 3306121 ggaacaggaa taaaaaaagc tctctttatc gagagctttt tccttacttt ttcttctgct 3306181 cgtcagaaat cgctttttca aatacatcct tgccggcagc acccggaatt acagtgtcac 3306241 cgataataaa ggttggaacg gctgtgatgt cagcctcttc ataggcgtgc ttcaaggctt 3306301 ggcgctgcac gtcctgatat gttcttgttt ccagtgctga tttgaatgat gcaccgtcta 3306361 atcccacttc ctcggcgagc ttcgtcaaga tgtcaatatc gccgatattt tggtcctcct 3306421 ggaaaaatgc ctgaaagaca cgggtgttgt attcatgtcc tttattgtat tccttcgcaa 3306481 aatggaagcc ttcaaacgcg aggtctgtat acggatgggg cgagacgttt ggaaaattga 3306541 tctcgactcc taatttctcc gccattggct gaattgatgt ctgccacatg tactgtttag 3306601 aaggatcatt gaccggatca agctgaggag atgggcttgg gcgcagttca aacggcatcc 3306661 actcgacttc aacatccttt ccttttatcg cttcttcaaa agcggctttt ccaacaaaac 3306721 aaaatgggca gacgtaatct gaataaactt taatgtgtac tgtcatgata atctcctttc 3306781 atactaaatt gattttaaac tgtaacaatt aaagttacaa ctgtttttta ataaagaagc 3306841 cgatttaggc ttctttcaga ttgatgacaa aatcctaaaa agttttagga ttttgtcatc 3306901 ctttcagcgt gattgaaaac ccttgaagtc taggaaagcc gagcattgga gcggagcgaa 3306961 tgctctaatt cgtgagcacc aacgcacagg cttgacaacg aatgcgaggg tttgtcgaca 3307021 cgctgaaaga agcctgtaaa ggcttctttt atgattccag caaacgctgg gcaatatatt 3307081 ctcctttttt gcagccgcct gggcatgcgt ataaagcaga accgattgtt tgtgtatatt 3307141 cgtttaacgc atcctttgct gaaagagcct tcagcatcgg gataaactga ttgtcgggat 3307201 ttttttgaaa actgataaac aggagacctg catccatata gccggttttc ggatcaagtc 3307261 cttctgtgta agagaaagct cttcgcaaaa tttgtttccc agtagatttc gctagactga 3307321 cgtgtgaatt agacggaatt tgattcagct tcacgggatc tgtttccttt ttctgcccaa 3307381 aaggcgcccc cgagcttttt ctgcggccga aggtatcctc ttggtccttg agggaagagc 3307441 ggtcccatac ctcaaggaac attttgattt tccgaaaagc catataggtg ccgcccgtca 3307501 tccagtcagg ctcaccagac tgaatccaca cgatcgagtt catcaacgtg tcatccttcg 3307561 tgctctggtt gcctgttcca tctttaaacc cgaagaggtt gcgcggtgtt tcaccatttt 3307621 ttccaccgct taaaaagcct ttgttcacaa aacggacctc acaagtgccg accgcttgat 3307681 ttagcaggtt acgcagcgcg tgaaacgcca cttgctcgtc gtctgcacac acttgaatgc 3307741 agatgtcccc gcctccctgc ttttcatcca ggttgtcatt gggcatcgct ggaagagcgg 3307801 ctaggtgctt cggttttttg cttttcagtc cgaagcggtc ctttccgtct ttttcaaaaa 3307861 agccaggccc gaatccgaat gtgaccgtta agttggaagg ggataaatca gcagactcac 3307921 ctgtatcctg cggcggcaga tactgatttc tctgctccgc tgacattttc ttgccagacg 3307981 tcagcatctg tgtgagactt gtccagtttc taaataacgt aatgatgtcg cttttgtctt 3308041 ttgctgttac atccagtgca gcaaaataga catacgtctg atgggcagtt gtgattccgg 3308101 cctgatgctt tccgtaaaac ggaacaatct gctcctcctc tttttcatcc tttttcgatg 3308161 gcttagccgc agtctgaaca agcggagcga gaccgccgag accgctggca ccgatcgcaa 3308221 cggctgcccc cgccatcgct ccccatttta aaatgtcccg tctgtgaatt tgttctggct 3308281 ttttctgttc atcgctcatg atgttacaaa actcctttta tagcacattc gcaatcttcg 3308341 acatggtttc agaaagagtc gtcagcttag tgctcagctc tctgatttgc ttttcactta 3308401 atttatcata agacgtatag gactgatcat ttgttttgta ttttgccatt aaaacttcaa 3308461 attcgctgaa ctccgtatcc agtttttccg tcaagtcgga gtgatctttt acaagcgcgc 3308521 ttttcactgt ttgataaacg gcttcggagc cttccacatt tgccataagg tcaactaaat 3308581 caattcgtga gtagcgctct tcttctcccg tgattttcga aattccggct tcgttcagaa 3308641 gctccatcgc gcctgcaaca atttgttcag gtgttaattt cagtgattga attgaaccgt 3308701 caagctcttt tacatccttg agaagctggt cagctgttgc cttttccccg gaaatatctt 3308761 gatccttcca aatggccttc tcaagcttat ggaagcctgt ccatttgtct ccttcttcaa 3308821 catcgttttc tcgtgcgtca attttcggat caagatctcc gaggctttca gcgatcggtt 3308881 cgattcgctc gtaataaaca cgcgctttcg catataacgt tttggacttt tcgatatcgc 3308941 cggatttcac agcacccgta aatgcttcag tcgctttgac aagctggtca ctctgctctt 3309001 tgacatagcc tttatactca tccgctgctt ttgccagctg atcgctagcc tttttgccgc 3309061 tcttcttcgc ttctgtcagg tcttctaagg atgctttcaa tgactcggat tctgtcttga 3309121 tttttcctgc atccggtttg tctttttgcg cttctgtgta gattggctga agatgctttt 3309181 cgatttctgt atattcgaat ggatagtcgc tgcgaatatc gttttcaaag gaaagccagt 3309241 agctgtttaa ctctttcccc ttcttttcaa tctctttttg gtctcctttt tccactgagt 3309301 cattcagctt agaaatgatg gtttccattt tatttacgga tgcggtgatt tctttagtga 3309361 ccccgctttt ttcagatgaa gctttttctt tggttgaaga tgtgtcattg gctccgcagc 3309421 ctgcgcacag cgcaaggatg catccggctg atacagcgat ttttgtgaaa ttcattttgt 3309481 cagttccttt ccgtttgtaa aatgttttgc cgcttctgaa acaagcgcaa tcagtaaaaa 3309541 gagtaaaatc aacatttgcg gaatcgtgct gtacacagac ggataaattc ctagcaccga 3309601 tacagacggc agccagcttt ctgcatcaga cggaagaatg cccgccagtt gaaggctgtg 3309661 aacgccggtt ccgagaaatt tcacgcacat atacaggaca accgccattg atagaagaaa 3309721 aaacggcttc aatggaatgc gcattccgag cttgatcatc agaacaccga cgatgacgag 3309781 aacgataagc cctgcggcag ttccgccgat cagttcagtg agcgggagct tcccgacaag 3309841 cccgatgaaa aagatgaccg tttcgagacc ttctcttaca actgccagaa atgcaatgag 3309901 cgcaaaggaa agcaggcttc gtttttttag tgcctgtgac ttctggatat tgattttttc 3309961 tctccattta tccattgagg cgtttctgtg cagccacacc ccgacataca aaagcatgac 3310021 agcggacagt acgccggtaa cgccgccaag caagaaattg ttttctccga atacactgga 3310081 ggagaacaga accgtgacac cgatgccggc tgctaaggaa acagccatgc cggcggacgc 3310141 cccgccccag atccatgtcg aggaacgcgt aacccgcgct ttttttgtca tggttaatag 3310201 cgctccgatg acaaggaggg cctccattcc ttcacgaacc gggatcagcg ccgcatccca 3310261 ccagctgtag ctgcttgaag cgatcggctc gagcaattga atcatttcgt caatttgctt 3310321 tgataccttt tcaggatggc tgccgatctc cgccttcatc agcgccagat tttcctccga 3310381 tgtcgtatag gcttctttcg attgggacac gacatctccc tcaacagcga gccaggatgt 3310441 aactaaattg tcgattgcgg atgacgcttc atccaattgt tttttttcta tgaactgttt 3310501 tgtgtctttc aagctttgta tataggctgt taaggacgcc cttgattgac ctgaggatgt 3310561 ctttttcagc acgacagcct gctgataggt ttctaaatga gacgcaagct cttcaagctg 3310621 tgttttgagc ttacgtgcgt cttgattgat aaaagaaaga gaaatcatcg cgatattcgc 3310681 gtccatttca ctgtgagaag aaaggttttc tttcttaata gaaggttctt cttttttcca 3310741 cttcgccttg aaggtgtcaa acgtttgttg tgccgaatcc atatccccgt cttttacgga 3310801 tttgatcatt tgcttgttta attgaattaa tgcggcgatc ggatcatctt ccgcatgtgc 3310861 cgcagaaccg aaaaccatca acaagctgaa tagaataagt gccagccccc gagccatcat 3310921 gttcctccta taattgaaaa tgattatcat tgtataacat aatcatagcc agttcctgtc 3310981 ctttgtcaat taaaatttga aggtctgaaa accttgatgg acagcaaaaa agctgtcctt 3311041 ttacagaaca gccctttgaa ggaaaatgaa cgattatctt cctgttttat acgtttgaat 3311101 ttcctcacga aacttgcgtg cagcactctc aggatcctcc gcctgactga tggcgctgat 3311161 catactgacg ccatcggccc ccgcttggat aacaggtgcg gcattatcta ttgtgattcc 3311221 gccgatgccg acaattggaa tgctgatgcc ttggcggcgc actgcttcga taagagatac 3311281 accctgtacc gctctcgtat cttttttcgt ttcagtcgga tagatcggcc caagcccgac 3311341 ataatccgct ccgtcttctt cggcttgctt cacctcagac atcgtatggg cagaaacgcc 3311401 gagaatcata tcacctatgg cagctcttac ctctttcgca tttgcgtctt cctggccgat 3311461 gtggatacca tcagctttca gattcagagc caattccaca tcatcattga caatgaacgg 3311521 aacaccagct tcacggcaag ctgcctgcgc tttttcagca aatttaatcc gagcctctcc 3311581 tgtcagcgca tccccgcctt tttcacggaa ctggtacagg gtggcaccgc cttttaacgc 3311641 tttttgtaca actgtaacag gatcggcttt cgtattgttt gaccccataa tgaagtatac 3311701 agataataac tctttcatca tttcccgaga aatacgagtc atgagacagt caccctttct 3311761 atagtcgccc attcttggac gtcttgttca gtaacagttg aaagcttgtt cagcaattca 3311821 atctgaaagc ttccagggcc tttgtcagcc gtctgctgtg cggcaagctg agcggcgacc 3311881 ccatacgaag aaatggccgc aatagcagca aacaatggat tttcttccac agcgcaaaac 3311941 gcaccgacga cggaagtcag caggcaaccg gcgcctgtca cttttgtcag cagcttgtgg 3312001 ccgttatgaa gggtgtatac atgtgacgtg tcggctatga catcaacttc accagttatc 3312061 gcaatgaccg tgtttagctt ttgtgccgcc tgctgagcca gccggatgat gtcgcctcca 3312121 ccttcacccg catcaacacc tttgatcagc caatcggtca cgccgacggt atgggcaatt 3312181 tccgccgcat ttcctctgat tgcagcaagg cgcacctcac gaatgatgtc acgtgccgat 3312241 tcagtgcgga acggtgttgc tccggcaccg acaggatcaa gaatgacggg aacgccatgt 3312301 tcattagctg attttcccgc gatgatcatc gcttcgactg actccttgct cagtgttccg 3312361 atatttaaaa cgagtgcacc cgcaattttc gccatatcgg cgacctcttc ttttgcgtac 3312421 gccataacgg gcgatgcgcc gagcgcgagc aggccgtttg ctgtgaaatt cgttacgaca 3312481 ttgttggtta tgctatgcac cagtgggcta tgccggcgga cagccgtaag acattttgct 3312541 gctgattgtg catccatatt tgcatcatcc tttactatct tttttcgggt cccataaata 3312601 cgatttcgta tgttcgagcc aagctctggc ggcaaacgac aagtacctgt cctttctcca 3312661 aataatggcg aggtgccaag ggatgaccgg atcgacaagc ggaatgactt tcactttttc 3312721 cgggtcaagg ccgcggcaga tccgttccgg caaaagcccg atcccaaggt tggcggatac 3312781 catctcacta ataaaatccc attgtgatgt ttcataaatg atatggggcc ggaacccagc 3312841 cttgatacat tccgtcataa ttcggttgtg caggacaaaa tcctctctga agaaaataaa 3312901 aggctcgtcc ttcaactcac gcagctgaca ttctttctca tcagccagcc ggtgggaagg 3312961 gtgaacgaca agcattaagg tttcttttac gattgtaaac gaatgaaaga tatcttcgtt 3313021 tgcgggaagg accacaacgc cgatatcaag agagccgtcc ccgacacctt cttggacttt 3313081 tatagaaccg tcttcgacta gctgaaaggt gacattcgga tagttttcac ggaaatcgcc 3313141 gagcactctg gggaaaaacc ccgatccgat catcggcggc agtccaatcc gtacgtgccc 3313201 tttcttgact tccataatat catttaattc tgacgtcagg ttttgaaatg atttaatgat 3313261 ttcctgcgcc tgcacataca tgctatgacc ggcatcagtc agttccacct gcctgccgtt 3313321 tcggtaaaac agttcaattc cgagctcttc ttctaaattt ttgatcattt ttgatatcgt 3313381 cggctgagaa acataaaggg attgggaagc cttcgtaaaa ctttttaaac gggcgacttc 3313441 caagaaatat gttaaatggc ggatatccat gcgcttcacc ctttctatag acaaaaggaa 3313501 tacttcttat tcttaatata tattttacct atagagagac cttatgtaca ataagtatat 3313561 aagggaggca tcaatatgaa aaaactgttg ctaaccgtta ttcaaatcgc tctgttattt 3313621 atatttgctc ggctgattaa ttgggtgaca gcccttcttc atataaatat tcccggcagt 3313681 ataataggga ttgtgattct tttcacatta ttgcacttta acattatcaa gcttgaatgg 3313741 atcgagcttg gtgcagcgtg gcttctcggg gagctgcttt tattttttat cccgtctgcc 3313801 gtcggagtga ttgaatacgg agacattatg tcgaaatttg gtgtcagcat tctgcttgtt 3313861 gtcatcatca gcacgtttgt cgtgatggtg tctacaggaa cgcttacaca actcatcgca 3313921 aagagaaagg agaaaaagca tacgtgttca tcggaattgt aagtttgttt ttaacggttt 3313981 tggtgtattt aggagcaaaa aaggtatatc aacgctttcc gcgtgtttat acgtcgccgc 3314041 tattggtgac gcccgctgta ttagtcggtc tgctgctgct ggtgaatgtc ccgtacgagt 3314101 cctataatct cggcggcgga ttgctgaccg atatgctaca gccggccacc gtggcattcg 3314161 cgatcccgtt atataaatat ttccctgttt taaagaaata cgcagtggaa attattttga 3314221 atgtggccgt cggttcatgc atcgcgatta tttctaccgc tcttattgcg aaatggcttc 3314281 acctcggcac cggcttaatt gacagcctcg tcccaagatc agtgacaacg ccgatcgcga 3314341 tgaacgtatc tgaaatgatc ggcggtatgc ctgccgtcac agccgtgttt gtgattttaa 3314401 ccgctttgct cggcacagtg atcggcccga tggtcatccg ttatttccgc attgataacg 3314461 aaattgcgcg gggcgtgctg cttggcacaa gcgcgcacgg agcgggaacg tcaaaggcat 3314521 ttgagctcag ctctgtgtcc ggcacgattt ccagcgtgtc gatgatctta gctgcgatta 3314581 tgacgctttg cgcggcgccg tttttgcttt catttatgta aaaaactgtc ctctcgaggg 3314641 cagttttttt tatgtgcttc cccttattga aaagctggcg aattccaata taatgtattt 3314701 gtggatacca aaggaggcac cctgatgcac aacttgcagg tgaggcggca ttatgccgcg 3314761 ttaaaaggat tttatttgtt tgcttttctc ggtacgggca gcataattcc cttactcagt 3314821 atgtatttaa cgaaggaaca gcatttaagc ggatcacagg tcggcttgat catgtcactg 3314881 ggcccgattg tgatgatttt ctttcagccg ttttggggca tgctgagcga ctatacgcaa 3314941 aaaacgaaag gcctgctggc ggtttgcaca tcaatcacag gcatcattgg attagcctat 3315001 attgcatttg acagtttccc tctgtttatt ttgattgcgg cctgttttgc agcctttcaa 3315061 agcacgatta ttccactttc ggacagcatt tcactaaggt acacacaaga aacaaacggc 3315121 aactacggcg gaatccgcct gtttggttct ctcggcttcg gtgtcgcggt gtttgccatg 3315181 ggacaggtga cgaaccagct gtaccccatt cacgtgatct ttatctttgg ctgtgccttt 3315241 ctgtgcattg ctgccatatt ggcttcacaa gtgcccggcc agcagaaaac aacaaaggtc 3315301 aatatccgca aaggattccg ggagcttatc agcaacaaaa ctttcctcat ctttatgatc 3315361 atcaccttta cgacatttgc tccaaactta gcgaacaata cgtatttcag tctttttctg 3315421 gacaaaagcg gcgcgtcact ttccgctatc ggcattttat ttttcatcgg tgtcatttca 3315481 gaaattccat ttatgagatt cgcccaaaca tttatagata aaatggggct gctcaacgtc 3315541 attatgctgt caggcggagt ctcattattc aggtgggcgc tctatttcac ggcgccttca 3315601 ctatggatca tttatgcgac ggtctttctt cagggagtgg ccatcggttt atttatcccg 3315661 gcggcgcttc aatatgtgaa aaagattacc ccaagacacg ttgaagcgac ggcgctgacc 3315721 atgtacgccg ccattggcaa cgggttcggc aactggttct gcacatttgc aggcgggtac 3315781 atttttgact acgtgtcgat cttcgcagtc tacttgcttt ttggcattct gagcatagca 3315841 ggctttggcc tgacattata tttaatgaag gctgaaaaaa acaaacatac acttcatcag 3315901 ccggctgtta cttttaaacc ataatgacta taatgaacaa aagaaaggat gtgcgttatg 3315961 aacgggcaag agcgaaacag catttcgaaa gggttgcagg ttgatattgt attgaaagca 3316021 gatcaaaaaa caggaaaact gacgagaggg acagtgaagg atattttgac gaaatcaaac 3316081 tttcatccgc atggcattaa agtccgtctt gaagatggcc gcatcggccg cgaccagcag 3316141 atcgtttcta cataaaaaaa agctgcccct gaacagggca gctttttcat tattttttct 3316201 gcagaaggac cactttcagg tagttgcctt ccggaaatgc cgaaatcgtt ttgaaatcct 3316261 ccggcagcgt aaattcctca atgatcgtgt agcgttcatt tgtttcttta aaggcggcat 3316321 caataaagcc tttgaacttc ttcatgccaa aggcgctgct gtttgtagag gcaacaatga 3316381 cacccttgtc agcagtgatg gcgatcgttt ccttcagcag gtttttataa tccttggccg 3316441 cgctgaaggt gcgttttttt gtgcgcgcaa aggaaggcgg atctagaata atcagatcaa 3316501 agcgcaaatc cttttttgca gcatatgaaa aatagttaaa aacgtccatc actttaatgt 3316561 cgtgcgcttc gtaatccagc ttgttcacgc tgaattgctc gatcgttttg gcaagacttc 3316621 gatttgccac gtcgacgctt gttgttttct ccgctccgcc aagcgccgcc gccacggaga 3316681 atgcacccgt ataagaaaac gtatttaaaa cggttttccc ttttgcatag cggtctctga 3316741 tcgccttgcg cacatgtctc tgatccaaaa agatgcccgt catggcgcct tcattcagat 3316801 ccaccgcgta ttgaatgcca ttctcttgga tgatgatcgg gaactcgccc cttctccctt 3316861 tcacgaagtc atcatcttca acgtattgtc cagccgtgtc gaagcgtttc ttctcgtaaa 3316921 tcgctttata atcaagatcc atctcatcca atgcggaaat cagcatgtct ttaaaggtgt 3316981 aaattccctt gctgtaccat tgaatcagca ggtagccgtc ataatagtcg atggtgacgc 3317041 cgccgacacc gtcaccctca ccgttgaaca ggcggaaagc tgttgtatct tgagcctcaa 3317101 atagtttggc gcgcgcttgg gccgcttttg ttaatttgct gagaaaaaat gcttggtcaa 3317161 tctgttcatg tttattgcgg gtaagcgtcc agccaacccc tttgttttgc aggccgtaat 3317221 agccccgcgc gagaaactcg ccgccgctct cagacacgat atcaacgagg tctccttctt 3317281 tcatgtgccc cgcactccct gcgagagctt ctttttcaat aaggggatag ccttttttta 3317341 ttttggcagc gtgtgctttt tttagggtga gtagcttcat atatgtcgtc ctctttccgt 3317401 ttgctttctc ttatggtacc acaaaacgcc aagatgtctg cattgacaga aaggaaaggt 3317461 ttttctacga tagacaaaaa gagttacgag gaggagcagc atggcaaaac gaattgacca 3317521 tacaggcatc atggtaagag atattaacgc gtccatcaca ttttatgaag aggtactagg 3317581 catgaaattg aaggatcgca tcactcacac gaacggtgta atcgagcttg cttttcttgg 3317641 ctttgaagac ggcccggaaa cagaaattga actgattcaa ggctacagca gcgagcttcc 3317701 cgctgaagga aaagtgcacc acattgccct gctgacggat gacatcgcgg ctgaatatac 3317761 aaaagcggaa aaaatgaacg caaaatttat cgacgaggag atcacaacac ttccaaacgg 3317821 ataccgttat ttctatatcg aaggccctga cggtgagtgg attgagttct ttcagcggta 3317881 aaaataaaga acgtacattt tgtgatgtac gttctttttt atctatacca actgatatac 3317941 gttgactcat cgcaaatcat agcttcccag cccatacgct caaccaattc atggatgttt 3318001 ttatctttgg ctaaaaagac attaatgaat gagtcatata cactcataaa cacaaaatcc 3318061 attttctcat cagttaaaac gagctctgtt gcggcttcat caagaaccgt ccgcaagttg 3318121 gcttcagtta tgtccaaaac gccgcggttt tccacaatcg gttctgcgta ataaaaccga 3318181 ttggatccgt tcgcacctaa tacctttacc aaactcggaa tatgaaaatt tgaaatatga 3318241 tcctcactgg gataatagag gtctccattt atgttttcat gtaacacctc agccaaatcc 3318301 tctctcgcga actcgtccct taaagcgcct atcgacgtca ttaaagccag cgccagctca 3318361 gcatgtgttt gaaagccgca agaagacata accttcttcc aggaaacagc cttgcctatt 3318421 cctcttattt cattatcgtt tggataaata tgttcataat cattttttct ttttgcattc 3318481 tcccatcctt caggcatttg gataaaagga gaaaagataa gagcagcaga tgagtattca 3318541 actggtactt gttgtaagat tggtgattcg tcatctaacc atatataatc tagcatgcgc 3318601 acctccttta catattctaa cattcctttc gtttgaaaga gatgatcagc cctatgacag 3318661 gctgatcatc tatcacatca catttttatc cccagattca accgcactct cttcccgcca 3318721 tttttgatga tcccatattc tgaaaaacgg atagtagata gcacaggtga tcagcagatt 3318781 taccagctgc ataactgcgc ccgacacctt tccgcctgtc gccaggtaac ctgatatgag 3318841 cggcggcatc gtccatggca ccgcgattcc ggccggtctt gccaccagcc cggtgctcat 3318901 gccgatataa gtcgcggtaa tcgtgaggag cggtgcgatg ataaatggga caataaggag 3318961 gggattcatg acaatcggca tgccgaaaat gatcggctcg ttgatattaa atagcgcagg 3319021 gccgattcct aatcgtccaa gctgcttcat ttgtttgctg cgggagcgca caagcatcgt 3319081 caggacaagc gccagcgtcg ccccgcttcc gccgacattg atccaaattt gaaaaaactg 3319141 agtcgtaaaa atactcggca gcgcctcgcc tgcttggaag gcgagacggt tggcatccat 3319201 cgcgccgtac caaatcggcg ccatgattcc gccaatgatg gaagccccgt gaatcccgca 3319261 cgaccaaagc agcatctgca caaattcagc gatcaggctt ccgccgagac tgccgccaag 3319321 gatggaaagc ggtgtgccaa gcaggtctcc tacgacattg tgcagactct gaaaaggtgt 3319381 catttcaatc agaagacgcg ccagccatac gagaagcaca atgataaagc cgggaatcag 3319441 cgcgacaaat gatttgctta ccgcaggcgg cacaccgtct ggcattttga agacgatatt 3319501 tttttgaata atgtaccgat agatttcggt tgaaaacaag gcgatcagca tggcgacaaa 3319561 taagcccttg ctgccgagca gcgtgatcgg gattccgccc cctaccatga tggactccgt 3319621 tgagccatgc ggtgtaaacg gcacctcaaa cggtgttgcc agcagaaatg cggcaattga 3319681 aatcgctccg gcagaaaggg catcgacacc atagctttct gccagccgat aggcgatccc 3319741 aaaagcggca atcatcgcca taatatcaaa cgaagcgtta acaggatatc cgagcttatc 3319801 ggcccactcg ttcccaaaca cactcgccat gaaatcagca taccccggaa tcggcaagct 3319861 cgttaaaatc aagaagacag acccgataat aatcagcggc atggtcagga taattccgtc 3319921 acgcaaagcg ctgagatgcc gctgcccggc aattttcccg gcgacaggca ttattttttc 3319981 ctccatcacc cgagtgaatg tgctcatctt aaaaaccccc ttttctcatt gctttgtgaa 3320041 caacctccgc aatgttttct ttatcttatt ttgaaaacgc ttacaaattc atttggaaaa 3320101 tttcctcttc atgcggaaaa aatctgcatt ttgctaaaca accctgccca tgaaaaattt 3320161 tttccttctt actattaatc tctctttttt tctccgatat atatatcaaa catcatagaa 3320221 aaaggagatg aatcatgaaa aacatgtctt gcaaacttgt tgtatcagtc actctgtttt 3320281 tcagttttct caccataggc cctctcgctc atgcgcaaaa cagcagcgag aaagaggtta 3320341 ttgtggttta taaaaacaag gccggaaagg aaaccatcct ggacagtgat gctgatgttg 3320401 aacagcagta taagcatctt cccgcggtag cggtcacagc agaccaggag acagtaaaag 3320461 aattaaagca ggatcctgat attttgtatg tagaaaacaa cgtatcattt accgcagcag 3320521 acagcacgga tttcaaagtg ctgtcagacg gcactgacac ctctgacaac tttgagcaat 3320581 ggaaccttga gcccattcag gtgaaacagg cttggaaggc aggactgaca ggaaaaaata 3320641 tcaaaattgc cgtcattgac agcgggatct ccccccacga tgacctgtcg attgccggcg 3320701 ggtattcagc tgtcagttat acctcttctt acaaagatga taacggccac ggaacacatg 3320761 tcgcagggat tatcggagcc aagcataacg gctacggaat tgacggcatc gcaccggaag 3320821 cacaaatata cgcggttaaa gcgcttgatc agaacggctc gggggatctt caaagtcttc 3320881 tccaaggaat tgactggtcg atcgcaaaca ggatggacat cgtcaatatg agccttggca 3320941 cgacgtcaga cagcaaaatc cttcatgacg ccgtgaacaa agcatatgaa caaggtgttc 3321001 tgcttgttgc cgcaagcggt aacgacggaa acggcaagcc agtgaattat ccggcggcat 3321061 acagcagtgt cgttgcggtt tcagcaacaa acgaaaagaa tcagcttgcc tccttttcaa 3321121 caactggaga tgaagttgaa ttttcagcac cggggacaaa catcacaagc acttacttaa 3321181 accagtatta tgcaacggga agcggaacat cccaagcgac accgcacgcc gctgccatgt 3321241 ttgccttgtt aaaacagcgt gatcctgccg agacaaacgt ccagcttcgc gaggaaatgc 3321301 ggaaaaacat cgttgatctt ggtaccgcag gccgcgatca gcaatttggc tacggcttaa 3321361 tccagtataa agcacaggca acagattcag cgtacgcggc agcagagcaa gcggtgaaaa 3321421 aagcggaaca aacaaaagca caaatcgata tcaacaaagc gcgagaactc atcagccagc 3321481 tgccgaactc cgacgccaaa actgccctgc acaaaagact ggataaagta cagtcataca 3321541 gaaatgtaaa agatgcgaaa gacaaagtcg caaaggcaga aaaatataaa acacagcaaa 3321601 ccgttgacac agcacaaact gccatcaaca agctgccaaa cggaacagac aaaaagaacc 3321661 ttcaaaaacg cttagaccaa gtaaaacgat acatcgcgtc aaagcaagcg aaagacaaag 3321721 ttgcgaaagc ggaaaaaagc aaaaagaaaa cagatgtgga cagcgcacaa tcagcaattg 3321781 gcaagctgcc tgcaagttca gaaaaaacgt ccctgcagaa acgccttaac aaagtgaaga 3321841 gcaccaattt gaagacggca cagcaatccg tatctgcggc tgaaaagaaa tcaactgatg 3321901 caaatgcggc aaaagcacaa tcagccgtca atcagcttca agcaggcaag gacaaaacgg 3321961 cattgcaaaa acggttagac aaagtgaaga aaaaggtggc ggcggctgaa gcaaaaaaag 3322021 tggaaactgc aaaggcaaaa gtgaagaaag cggaaaaaga caaaacaaag aaatcaaaga 3322081 catccgctca gtctgcagtg aatcaattaa aagcatccaa tgaaaaaaca aagctgcaaa 3322141 aacggctgaa cgccgtcaaa ccgaaaaagt aaccaaaaac ctttaagatt tgcattccaa 3322201 gtcttaaagg tttttttcat tctaagaaca ccacacacaa cctttttccc atccattgta 3322261 caggcttttc atactattgc tatacagcca tgaacagcat aaaatgaacg ttattacagt 3322321 tatcaccaca tatggcggga ttgtgactgg gcaggcaggc aagacccaat gatgcaaagg 3322381 gagtattaat gcctaaaaaa cagggcattt taactcttct tttcgtgttg ggctcataac 3322441 ggcgccttgg acaaccccct attctcatgc tccgtcgtcg acgcgggcat ttttgtcatt 3322501 ttcagccggt atttctcact tttttcattt tgattgtcaa cttttcattt gatacgatga 3322561 acaagccgac ttttcttcag caaaggaggt tttaattgct tgcataaaga gattgcaaaa 3322621 gaattactgc tgctcgcagg aggaaaaaac aatattatca gcatcagcca ttgtacgacc 3322681 cgtcttcgtt ttgatgtaaa ggacgagacg aaaattgata tacatgccat tgagaacctg 3322741 caaggtgtgc agggcacctt tttccgctat gggcttttcc agattatctt cggagcaggc 3322801 gtcgtcaaca aaatatataa agaagtcgtt catgtatggg agaccgcgcc ttctgaagag 3322861 cctgtccacc agaaaaaagc cagccggaag ctgaaccctg ccgcagcttt tgcgaaaaca 3322921 ctgtccgata tttttgtgcc gattattccg gcaataacag caagcggcct gctcatgggg 3322981 ctgatcggca tgattaaggt gtttcattgg ttcgctgccg gcagcccatg gattaaaatg 3323041 ctcgacctcg tgtccagcac agcctttatt ttactgccga ttttagtcgg cttcagtgct 3323101 gcacggcaat ttggcagcaa cccataccta ggggcagtga ttgcagggct tttgacgcat 3323161 cctgatctgc tggacccgtc tatgctcggc agcaaaaccc cgtcttcttt agacatatgg 3323221 gggcttcata tcccaatgat gggctatcag ggttccatga taccgattct tctttccgtt 3323281 tttgtcatga gcaaaattga gaagctatta aaatcgattg tgccgaagtc gcttgatgtc 3323341 gtgatcattc cctttattac ggtcatggtg acagggtgcc tcgcgctgat tgtgatgaat 3323401 cccgccgcgt ccatcatcgg ccagatcatg acacaatcga tcgtctatat ttatgatcac 3323461 gccggcattg ctgccggagc tcttttcggc ggcatctact ccaccatcgt cctatctgga 3323521 ttgcatcata gcttttatgc aattgaggca acgctgcttg ctaatccgca tgtcggtgtc 3323581 aactttttag tgccgatatg gtcgatggcg aatgtggccc aaggcggagc ggggcttgcg 3323641 gtattcctca aaacgaaaca atcaagcctg aagaaaattg cgctccccgc ttctctgacc 3323701 gcgtttttag gcattgttga gccgattgta ttcggggtaa atctcaaatt gatccgtccc 3323761 tttatcggag cagccatcgg cggtgctatt ggcggagcat acgtggttgc ggtacaagtt 3323821 gtggcaaatt cctacggact gacaggcatt ccgatgattt caatcgtgct gccgtttggc 3323881 gccgctaatt ttgttcatta tatgatcggt ttcttgatcg cagccgtctc tgcttttata 3323941 gctacattgt ttctcgggtt taaagaagag acagaataac tggatttatt cgatttcatt 3324001 cataaaacgg gggatgaaag gacaaaaaag ctatgaaaat taaaagaatc ttaaatcata 3324061 atgctatcgt cgtaaaggat caaaatgaag agaagattct cttgggtgca ggaattgcgt 3324121 ttaacaaaaa gaagaatgat attgtcgatc cgtcaaaaat agaaaaaacc tttatcagaa 3324181 aagatacacc tgactataag cagttcgaag agattttaga aacattgcct gaagaccaca 3324241 ttcagatttc tgagcaaatt atctctcatg ccgaaaaaga gctgaacatc aaaatcaacg 3324301 agcgcattca tgtcgctttt tcagaccatc tttcttttgc aattgaacgc ctgagcaatg 3324361 ggatggttat caaaaatccg ctgctgaatg aaatcaaagt cctttatcca aaggagttcc 3324421 agatcggctt atgggccaga gcactgatta aagataaact ggggattcac attcctgatg 3324481 atgaaatcgg caatatcgcc atgcatatcc acacagcaag aaacaatgcc ggcgatatga 3324541 cacaaacgct tgatattaca acaatgatcc gtgatattat cgagattatc gaaattcaac 3324601 tgtctattaa tatcgttgaa gataccatct cttatgaaag gctcgtgacc catctccgct 3324661 ttgccattca gcatatcaaa gcaggcgaat ccatttacga gctggacgca gaaatgattg 3324721 acatcattaa agagaagttt aaggatgcct tcctgtgtgc cctaagcatc ggcacctttg 3324781 tgaagaagga atacggcttt gagtttcctg aaaaagaatt gtgctacatc gccatgcata 3324841 ttcagcggtt ctaccaacgg tcagtcgcac gctgagacaa acaaaaaacg cttttgatca 3324901 tctcaaaagc gtttttttat ctgatttatt ggttgatcgc cggattccca atcgtattcc 3324961 acttcgtata ggacatgtaa tggaaatact catcgcgata cggatgtttt gtattggagt 3325021 tccaaggctt ttctccgccg cagaagtgca cgattgccgg gttttctctt gtttcattat 3325081 attgcttccg ccctaacaga gtcgatgggg ttttcagctt taacatgata taggtttgag 3325141 cgttccagcg cggatgaagt tcataccact gatcatacaa gatcgcattc agtgcatctt 3325201 ggtcatgcag cacaagaaag tcttcgtctg ggtgttcatt gataaagttg atgacttttt 3325261 ctgtgatgtt ttgctttctc caagactcaa aatcaataat catgatacct gagttaaaat 3325321 acttccctgt atcagtgacg ttcatttctt tcaggcgttc atgctgcccc gcatcctcaa 3325381 cagcggctac ggtgtatggc gcaatgtcta agtcccatag cttagaaata tcctctagga 3325441 caagcgcatc acaatcgatg taaatcattc gtttgatgct ttcatcctta attaagtcgg 3325501 gaatcgaaat gcggtaatac gcggcttttg taatatggct gctctcaacc gcatgttcat 3325561 acatgttggt atccacttct aaaaactcaa tcggcactcc gaatttcaaa gtggtttctt 3325621 ccagtctttt tttgttatca ggcttaattc cgccatcaat gacgtataat tttacctctc 3325681 tctcctgatc catgttagtc aataaagaaa cgaacatccc acctaaatga cgagcataat 3325741 tatcatctgc gcatgatacg atatgcatga tttcatcttt cctcaatggt attcatctcc 3325801 ctttttgttg tacaagttac ataccctttt tcaaaaaaat aaacacgttc tccgacattt 3325861 ttttaaacag aatgtgtgat acaacaaaaa aggtgtcatt ttttgaagat gcgataaagc 3325921 caataaagaa tgaaaaagct tgcgattgtg atggcttcag ccgagacgat ataccacggc 3325981 catggcccga gaacatctaa gagagaggaa ccgcccggtt ttttcgtcaa atacatataa 3326041 ttcgcgccaa gccagcgatc aatcagaaaa atacagacgc cgtacacatt aacaagcagg 3326101 actgtcaccc ataacgagcg ctggcccatt ctgtaggtgc caatcacagc catcagcaga 3326161 caggataaaa acacagaccc gtgagaaata aaaaagagga tatatcggat atgcggaaat 3326221 gaaaacatac cgaggtcagg agtggcaaga gcctgaatcg aactgccgat gccgacaaaa 3326281 aacaaaaaca caaacagctt tctgcttttt gtcactaaca taatagctga caaatacacc 3326341 gacaggtcac taagctggag aggcaatgaa gtgcgcaccg accacctgtc cgtggcgacc 3326401 atccatattt gatagccgat ttgcgaacca agcaaaagaa acacaaacag agaacgcaaa 3326461 aaccggctgg ccctcggctg cttgacctca tcttggaaca aaaacaacag aatggccaaa 3326521 agggagataa tcgctaacgt cactacatgc tctgtcgaaa acagatgaaa cggatcatgc 3326581 ttatagtcgg attgaacata tttttgcaaa actgcacccc cgttttcggg tttttgttta 3326641 ttttggcgtt gtttgggctt tttttattca accgatatat gggcttgaag ttcacaccag 3326701 actctgttaa aattcgtttc atagctaatg attctgataa tttaaggcag gcctaaaaaa 3326761 tggaacgttc acatcaacat cagcagcttc ggaaggaaga acacgataca ctttctaagc 3326821 tcaaacaaat gcccgtcgag tcactcaacc tggaagccat ttcgatcgct acgaatctgt 3326881 atcggtctgc acaaaggctc cgtgtcaaaa tggagactga ggttctttct acctataacc 3326941 tttcttggac cgctttctcc attctttatg atctatgggt atggggagcg ctcgaaacga 3327001 gaaaaatcgc tgagctgtca gggatatcta cagctacagc aagcaacgtg atcaaaacgc 3327061 tcgaaaaaaa gagtttttgc cgtaaaagca tcgacacaag agatcggcga ctcgtgtttg 3327121 tctcaatcac cgattccggc aaacaagcga tcgaagaact ctacccggag tttcacaaag 3327181 gggaaacaga gctcattgcg ggaatgacga aggacgaaca gaaaatattg acagggctgc 3327241 ttagaaaggt agctgacaat cttcatacaa cataagcttt gacgggaatc cagtagcggt 3327301 ttgtctccct gtttcagaga gccggcggta ggtgcgagcc ggcgcacagg caaacgtgaa 3327361 ttacctcccc aagctttctt tgtgaacctt agtagcaaag aacgggaaac cgttattcga 3327421 atgagcggaa gacaatgtct tcaaccaggg tggtaccgcg tgcattgagc cacgtccctt 3327481 attgggatgg gctctttttt gtgtttgtaa aaaaggagga aaaatgatga gaacatttga 3327541 gcagctcaca gcgtcacaac aaaaagaggt agaaagacag cttcagctat acatgacagg 3327601 cgcccacgaa gtcataccgc cggaggaatt aaaggcaaag ctcgtgaaat caatttccac 3327661 gggcacgccg cttaaaatta agctcggatt agatccgtct gcaccggatg tacatttggg 3327721 ccatacggtt gtgttaaata agcttcgcca atttcaagaa aacggccaca ttgtccagct 3327781 gttaattggg gatttcacag gaaaaattgg tgatccgacc ggaaaatcgg cagccagaaa 3327841 gcaactgact gatgaagaag ttcagcacaa tgccaaaacc tactttgagc aattcggaaa 3327901 agtgcttgat ccagaaaaag tcgagcttca ctataactca aaatggctga aaacattgaa 3327961 tctagaagat gtcattgaat tagcagggaa aataacggta gcccgcctga tggagcgcga 3328021 cgactttgaa gaacgcatcg ccatgcaaaa accaatctca ctgcatgaat tcttttaccc 3328081 attgatgcag ggctatgatt ctgtcgttct cgaaagtgat attgaattag gcggaacgga 3328141 tcagcatttc aatgtcctca tgggacggca tttccaagaa cgatacaaca aagaaaaaca 3328201 agtcgtcatc cttatgccgc tcttggaagg cttggatggc gtcgagaaaa tgtcgaagtc 3328261 gaaacacaac tacattggca ttaacgaaca tccaaacgac atgtacggaa aaacgatgtc 3328321 actgcccgac agcctgatga aaaagtacat ccacttggcg acagacttag agcttgaaga 3328381 gaaaaaacag ctcgtaaaag acttagaaac cggcgccgtt catccgcgtg atgccaaaat 3328441 gcttttagcc agaacaatcg tccgaatgta tcacggagag aaagcagcag aagctgccga 3328501 acactcgttt aaaacagtct ttcaggaaaa cagcctgccg gaagatatac cggccgtaaa 3328561 ctggaaaggc gaaaaaacga tagcgatgat tgatctgctc gtcaagctaa agctcctctc 3328621 ttcgaagagc gaggcgcgcc gcatgattca aaacggaggt gtacgcatcg acggagagaa 3328681 agtaacagat gttcacgcca aagcagagat aagagagaat atgatcatcc aagtcggcaa 3328741 acgcaagttt ttaaagctcc aataatctga tattccgaaa cgcttatgac ccttcattca 3328801 taagcgtttt tttgcaggta taaagcactg tcttttcaaa aacgctctcc atcttgcagg 3328861 aaactccttt agcatcccga aatattcccc aaccatacat ttaggggagg tttatttttg 3328921 atgaaaaagc ttttgactgt catgacgatg gctgttttaa ctgccggcac actgctcttg 3328981 ccggcacaga gtgtcacccc tgccgcgcac gctgtacaaa tatcaaatag cgagcgcgag 3329041 cttccattca aagcaaaaca tgcgtactct accatttctc agctaagtga agcaatcggc 3329101 cccagaatag ccggaactgc agctgaaaaa aagagtgccc tattgatcgc ctcatcaatg 3329161 agaaaattaa agcttgatgt gaaggttcaa cgattcaaca ttcctgaccg gcttgagggt 3329221 acactgtctt cagcaggacg cgatattctt ctccaagcgg cgtcgggctc agctccgact 3329281 gaggaacaag ggctgacggc cccgctttac aatgcgggat tgggctatca aaaggacttt 3329341 accgctgacg ccaagggcaa aatcgccttg atttccagag gagacctgac ttattacgag 3329401 aaagccaaaa atgccgaagc cgccggagcg aaagctgtca tcatttataa caacaaagaa 3329461 agcctcgtgc ctatgacgcc aaacctgtcg ggaaataaag tcggcattcc ggtcgtcggc 3329521 attaagaaag aagacggcga agcacttacc cagcaaaaag aagccacctt aaaactaaaa 3329581 gcattcacaa accaaacctc ccagaatatc atcggaatca aaaaaccaaa gaacatcaaa 3329641 catccagaca ttgtgtacgt gaccgcccat tacgacagtg ttcctttttc gcccggagca 3329701 aatgacaacg gctcaggtac ctctgttatg ctggagatgg cgcgtgtctt aaaaagcgtt 3329761 ccatctgata aagaaatccg ctttatcgct ttcggcgccg aagagctcgg cctgctcggc 3329821 tcctctcact atgtagatca tctatcggaa aaagagctga aacgaagcga agtgaacttc 3329881 aacttagata tggtaggcac aagctgggaa aaagcgtctg agctgtatgt caacacattg 3329941 gatggccaat ctaactatgt ttgggaatcc agccgtacgg ctgctgaaaa aattgggttt 3330001 gacagcctgt ctctgacaca gggaggatca tctgatcatg tgccattcca cgaagccggc 3330061 attgattccg ctaactttat ttggggagac ccggaaacag aagaagttga gccgtggtat 3330121 catacccctg aagactcgat cgaacatatc agcaaagaac gcctccagca agcaggcgat 3330181 cttgtgacag ccgctgtcta tgaggctgtg aaaaaagaga agaaaccgaa aaccattaag 3330241 aaacaaatga aggcgaaagc atctgacatt tttgaagata tcaaataaaa aaagacggca 3330301 cttgggtgcc gtctttttta atccacttct ttcttaatcc ccagcatttt ctcatctagg 3330361 taatgggcaa tctccgcggc ttctttcagc tcatctgtta attgcttagg aacgtcattg 3330421 ttcaatttat aataaatttt atgttcaagg ctcgcccaga aatccatcgc gattgtccgg 3330481 atttgaattt ctgctttgac gtattccaca cggttcgtta aattcacagg catctcaatg 3330541 attaaatgca ggcttcgata gccattcggt ttgggtgtct ggatataatc ctttaccttt 3330601 acgattctca aatcttcatg ctgcttcaac acattcacga cattataaat gtcagaaata 3330661 aaggaacaga tgatgcgcac gccggcaatg tcgtgaatat gctccttcat ttccttcgtc 3330721 gtaatctcac agccctttct cattaactta ttcacgatgc tttcaaagct ttttacacgg 3330781 gattttgtat gttcaatcgg gttgtgtccg tgaatgaggt tatattcctg gctgataatt 3330841 gagaactttg tatcgagcgc atctagcgca aatttataaa ctaataactc atttttccaa 3330901 tcttccatta ctgtttttaa atcgtccata tgtgttacag ataaatccat gttcgtcatc 3330961 tcctttaacg gaactttatc cgctgtccat gtactagacg tccctgtctg ctgcaaggtt 3331021 ctatgaattt ttttacaaaa tgcggtcgat tgtaacaaaa aaagaccgca tgaaacgagc 3331081 ggtctttttt attatcggaa atagctgatc aataatccga tcgagagcag gaatccgaaa 3331141 aatgtatttg tttgggctgt tgatttcatt gcgacaatca tattcatcgg catttcgttc 3331201 tggacgaagc ccttcactgc ctgaaccggc ttaggcacgc tcaaaaagac gacaaacagc 3331261 catgggcttg cggcaccggt aataaccaag ccgacaaccc agatataagc gacggcaaac 3331321 gacgcagcta acagagtaac agctccctta tgccccatca aaatcgccaa tgttttgcgt 3331381 ccgccttttt tgtcctcttc aatatcacga atgttgttcg acaggttaat cgcgccgaca 3331441 agaatcgcaa tcgggatgga aatcaaaatg ctctgcatat tgatcttatc tgtctgaatg 3331501 aaaaacgaaa tcagcacaaa caccgaaccc atgcaaatgc ctgagaataa ttcaccgaac 3331561 ggcgtgtacg caatcggcag cggcccgcct gtatacaggt agccgatcgc catgccgaca 3331621 aggccgatca gcgcaagcca ccagctgctg ctggcacaaa tatagacacc gagcaaaatg 3331681 gcaatcccgt atgaggcaag agctaattgc aaaatcgttt taggcttcat tccgtggcgt 3331741 acaatggccc ctccgattcc gactgattct gctgtatcta atccgcgttt aaaatcatag 3331801 tattcattaa ataagttcgt cgcgatctgg atccataggc aagaaaacag catagccaaa 3331861 aacagcagca gatcaacctt cacataaaac atcgccaaaa cggttccgag cagcacaggc 3331921 acaaacgatg cggttaacgt atgaggacgg gttaactgcc aaaggatctg ccccatgctt 3331981 tctttttgcg gcgctgtctg accctcaccc ttatttgttt ggttcatctt cctcttcctt 3332041 tctattaaaa ggcttacttt ttttcagccg gcagcttaat aaaaaactcc ttttgcttcc 3332101 ttatctatca taatgacttc tcccttattt cacaagatac cgcaagaagg cgttttcttt 3332161 cttattatac gcttctcgcc ctgatttcat taggtttctg ctttcacttg aacgaacagg 3332221 tacagaaaaa tttttttaag tacattacac tttttaaaag ttaaaaagat cttttgactc 3332281 caggtatctt ttcctttatt atgaatcagc tcgaaacatt ccattcttgc ccttgcaggt 3332341 ataaagattc attttcaaaa acatacgccg atatattaat ttgagggaga ttagggaaaa 3332401 aatgaaactt tttgagcatc tgatcgtcaa ataatcatgt gattgtcgaa aaaacgggaa 3332461 gggaattttt gatatgctgc aattaatgaa acagctgtat gaaaaacccg ctgtcaagtg 3332521 gacatgtcat acaggctttt atttgatgat actgcttgtt ttgtttttta tgtatggttt 3332581 tcacaccgcg aataccggtt catatattta taacgatttc taattggaga gagaataact 3332641 atgaaacttt tacatgctat tcaaacacat gcggaaactt atccgcaaac cgatgccttc 3332701 cgctctcaag gccagtcgct cacgtatcag gaattatggg agcagtctga ccgcgcggct 3332761 gccgcgatcc aaaaacgcat ttctggggaa aagaaatctc ctatccttgt gtacggccac 3332821 atggagccgc acatgatcgt ttccttcttg ggaagtgtca aagcgggaca tccttatatt 3332881 ccggttgacc tgtctattcc gtccgaacgg attgcgaaaa ttatcgaaag ctctggagca 3332941 gaattgctga tccatgcagc aggactctca attgatgcag tcggccagca gattcagaca 3333001 gtttctgcgg aagaactgct ggaaaacgaa ggcggctctg tcagccaaga tcaatgggtc 3333061 aaagaacacg aaacgtttta tatcatttac acttccggga gcacaggaaa tccgaaaggc 3333121 gtgcagattt ccgctgcgaa ccttcaaagc ttcacagact ggatttgtgc agactttcca 3333181 gtcagcggag gaaaaatatt tttaaaccaa gcgccgttct catttgattt gtctgtcatg 3333241 gacctatatc cgtgccttca atcaggcggg actttacatt gcgtgacaaa ggatgctgtg 3333301 aataagccga aagtcttatt tgaagagctg aagaagtccg ggctgaatgt gtggacatca 3333361 acaccttcct ttgtgcaaat gtgcctgatg gatccgggtt tttcacagga tctgctgcct 3333421 catgcggaca catttatgtt ttgcggagag gttcttccgg tttctgtggc caaagcgctg 3333481 cttgagcgtt ttccgaaagc gaagattttt aatacgtacg gcccgactga agcgacagtg 3333541 gctgtcacat cggttgaaat tacgaatgac gtcatcagcc gcagcgaatc gcttccagtg 3333601 ggcttcgcca aaccagatat gaacattttc attatggatg aagagggaca gccgcttcct 3333661 gagggagaaa aaggagaaat cgtcattgca gggccgagtg taagccgagg ctaccttggt 3333721 gagccagagc tgacggaaaa agcgtttttc tctcatgaag gccagtgggc ataccgaact 3333781 ggcgatgccg gctttattca agacggtcag attttctgcc aaggacgttt ggattttcag 3333841 attaaacttc acggctatcg aatggagctg gaggaaatcg agttccatgt cagacagtca 3333901 cagtacgttc gttctgctgt cgtgattcct tatcagccaa acggaacagt tgagtatctg 3333961 atcgctgcta ttgtgcctga ggagcatgag ttcgagaagg aattccagct gacaagcgct 3334021 attaaaaaag agcttgccgc ttctcttccg gcatatatga tcccgagaaa atttatctat 3334081 caggatcaca ttcaaatgac ggctaacggc aaaattgacc gaaaacgcat tggcgaagag 3334141 gttcttgtat gacgccttac agctcgtttt tattctttat actgcttggc attcttcttc 3334201 tgccgacgat cattctcggc ttaaacggaa aaagatttca agcatacaac atgttcatat 3334261 ctatcattat attggcttta attttttcgc acgacttaca cggggtcatc gcgctgtgcc 3334321 tgtttacaat atggcaggtg ctcctgatca gcggctatct ggcataccgg cagaaagcga 3334381 acagcggctt tgtcttttgc ggagctgtta tcgcgtctat tctgccttta tttctgtcaa 3334441 aaatatggcc gtttctttca cacccgcagc cgcatcatcc gccgcataac ctgatcagct 3334501 ttttagggat ttcatattta acctttaaag gcgttcagct gattatggaa gcaagagacg 3334561 gactgctgaa agaacagctg ccattgcacc gtctgctgta tttcatcctg tttttcccga 3334621 cgatttcctc cggcccgatc gacagatacc gccggttcgt caaggatgaa cagaaggctt 3334681 ggacgaaaga agaatacgcc gacctgctgt atacgggaat ccataaaatc ttcatcggtt 3334741 tcctgtataa atttattatc ggctacgcga tcaatacgta cttcatcatg aatcttcccg 3334801 caatcacgca caataagatt cttgggaacc tgctgtacat gtacggctac agcatgtatt 3334861 tattctttga tttcgccggc tacacgatgt ttgccgtcgg ggtcagctac attatgggca 3334921 ttaaatcacc agaaaacttt aataaaccgt ttatcagtaa aaatattaaa gatttctgga 3334981 atcgctggca tatgtctctg tcattttggt tcagagatta tgtgtttatg agattcgtat 3335041 tttggatgac taagaaaaag tggatcaaaa accgtatggc cgtctcaaac atcgggtatt 3335101 tcctgctgtt tatgctgatg ggggtttggc acgggctcgc gccgcaatat atcatttacg 3335161 gcctctatca cgccgttctg atgacgtgtt acaacttttt cgagaagtgg aataagaaat 3335221 ataaatggct gccgtccaac cgctggacaa ccattctcgc tattgtgatc acattccatt 3335281 tcgtttgctt cgggttttat attttctcag gaaaaccatt tcatcaccac cattaaagga 3335341 gattagaaag ctatggattt taaacaagag gtattagacg ttttagcaga ggtttgccag 3335401 gatgacatcg taaaggaaaa tcctgatatt gaaatttttg aagaaggttt gcttgattct 3335461 tttggaacag tagaattgct gcttgcgatt gaaaaccgtt ttgatatttt agtgccgatc 3335521 actgaatttg accgggacgt ttggaataca cctaacaaca ttgtaaatca gctgtctgag 3335581 ttgaaataat gaaaaagcgt tttttcggtc caattatttt ggcgtttatt ctattcgcag 3335641 gcgccatcgc aattccatct tcatggctga caggcttcat caccgataag cgtgtgaaag 3335701 agtcagcaac agccttgaat ccgagtatgt ttcaagggct atatttacaa gatcagatgc 3335761 tcaaagatcc gacatatctt ccgatttacg ggtcttctga gctttctcgg ctggacgagt 3335821 tccacccatc taattatttt caggtaaaca atgagggatt cacgccatac cttgtcggca 3335881 aaggcggatc ccagtcattg attcattctt taaacttcgc tgcccacatg gatcagctga 3335941 agggcaaaaa aatcgtattc atcgtgtctc cgcaatggtt tattaagcgc gggtctgatg 3336001 aacagcattt cgcgccgaac tattctgcgc tgcaagggct tgatttggca tttaacgatc 3336061 agatcgatcc tgaaattaaa aagaaaatga tgaaacgcat gcttcgcttt aaggctgtgc 3336121 aaaacgatgc cattctttct gagctgtaca aagcaatggt aaacggtcag acgtggaaag 3336181 tgaacgcgct gaagccggcg gcgaaagtgt attacagcat gctggaaaag aaagatctgt 3336241 attattcaac gacagaatca tccgggccaa agcgctatat ctcgcagtca gtaaaggata 3336301 agtcatggtc tgaattgaat aaactagcgg atcaatcggg caaacgccac tccggttcta 3336361 acgattttca catcgacaac cctgtctata aaaagctgaa gccgaaagtg cctaagctga 3336421 aagggaaaaa caaaggaaga tcgtatgcgg tgtcaccgga atatggcgac tttgaaatga 3336481 tgctcgatat cctgaaggat gcgggcgcag agcctatgtt tgtcaccatt cctgttaacg 3336541 ggaaatggta cgattacacg ggcttcccga aaaaaggacg cactgactat tacaaaaagg 3336601 taaataaaca aatcagagcg aagggcttcc aggttgctga tttctcaggg catgaatatg 3336661 acccgtattt catgaaagac accattcaca tcggctggaa aggctgggtg tatgtcgata 3336721 aagcaattga cgaattttat aaaaccggaa aagtcacttc atcctgagca tctcatagga 3336781 cgcggctgca tatttcctgc taagatttgt aatagtaaag gaatcacagc caacttaatt 3336841 aagaggtgtt acatccaatg aagatgacaa ataatacggt tttaatcaca gggggttctg 3336901 ctggcatcgg gcttgaactg gccaagcgcc tgctggaact tggcaatgaa gttatcattt 3336961 gcggacgcag cgaagcacgt cttgcagaag cgaagcagca gctcccaaac atccatacaa 3337021 agcaatgtga tgttgcagac cgttcgcagc gggaagcatt gtatgaatgg gctttaaagg 3337081 aatatccgaa cttgaatgtt ctcgtcaaca acgccggcat tcaaaaggaa attgacttta 3337141 aaaaagggac agaggagctt tttgtggacg gtgatgaaat tgaacttaat ttccaagcgc 3337201 ctgtccattt atccgccctt ttcacacctc atttgatgaa gcagcccgag gcggcaatcg 3337261 ttcaggtcac atccgggctt gcgtttaacc cgttagctgt ttatccggtg tactgcgcaa 3337321 caaaagcggc acttcactcg ttctcgctta cgctcagaca ccagctccgc gacacgagcg 3337381 tggaagtgat tgaaatggca ccgcctatgg tggacacggg cttaaaccaa aaatcacgcg 3337441 ataaacaagg cctgacgtac cggggcattt catctgaaga atatgttcaa tatttcttgg 3337501 acggcttgaa ggaaggcaaa caggagatta caaatgaacg tgttgaaggt cttcgggatg 3337561 ccactcgcgc cgattatgac aggttattcg agcaaatgaa cacgcaggag aattaatttc 3337621 tcctgctttt ttcatatgaa tttcttacaa atttgagcaa acctattgcg attatttgtt 3337681 gaaggtatac aatagaatat aattattttc aaataagttt gataatataa acaatttaac 3337741 agcagggaga ttgaccatga ctaaacaaac aattcgcgtt gaattgacat caacaaaaaa 3337801 accgaaacca gacccaaatc agctttcgtt cggaagagtg tttacagacc acatgtttgt 3337861 aatggactat gccgcagata aaggttggta cgatccaaga atcattcctt atcaaccctt 3337921 atcaatggat ccggctgcaa tggtctatca ctacggccaa accgtgtttg aagggttaaa 3337981 ggcttacgtg tcagaggatg accatgttct gcttttcaga ccggaaaaaa atatggaacg 3338041 cctgaatcaa tcaaacgacc gcctctgcat cccgcaaatt gatgaagaac aggttcttga 3338101 aggcttaaag cagcttgtcg caattgataa agactggatt ccaaatgcgg agggcacgtc 3338161 cctttacatc cgtccgttca tcatcgcaac cgagcctttc cttggtgttg cggcatctca 3338221 tacgtataag ctcttgatca ttctttctcc ggtcggctct tattacaaag aaggcattaa 3338281 gccggtcaaa atcgctgttg aaagtgaatt tgtccgtgcg gtaaaaggcg gaacaggaaa 3338341 tgccaaaacc gcaggaaact atgcttcaag cttaaaagcg cagcaggtag ccgaagagaa 3338401 aggattttct caagtactct ggctggacgg cattgagaag aaatacatcg aagaagtcgg 3338461 aagcatgaac atcttcttca aaatcaacgg tgaaatcgta acaccgatgc tgaacgggag 3338521 catcctggaa ggcattacgc gcaattcagt catcgccttg cttaagcatt ggggccttca 3338581 agtttcagaa cgaaaaattg cgatcgatga ggtcatccaa gcccataaag acggcatcct 3338641 ggaagaagcc ttcggaacag gtacagcagc tgttatttcc ccagtcggcg agctgatctg 3338701 gcaggatgaa acactttcga tcaacaacgg tgaaacagga gaaatcgcaa aaaaactata 3338761 tgacacgatt acaggcattc aaaaaggcgc tgtcgcagac gaattcggat ggacgaccga 3338821 agtcgcagcg ctgactgaaa gcaagtaaga aaaaagccgg cccattacag gccggctttt 3338881 tttacgcttc aattttgttg aaaaactgcg gcagatacgc tttgtgcgcc tctagcattt 3338941 cgtctaaaat ctgtttggcc acagtatcgg acgggacaag cgggttaatc gtcatggcaa 3339001 ggagcgcagt ttgatagtca cctgtaactg ccgcttctgc cgcgacacgt tcaaaggatt 3339061 tgatttgctg gacaaggccg cggacagaca ccggcaagtc gccgacagca attggcttag 3339121 ggccggtttt cgtcatcaca cagttcactt caactgcgga atcgtctgga atactcgcta 3339181 ttgcaccatt attgatcgtg ttcaccggct gaatgtcatg tttatcatta taaatggagc 3339241 tgattaagtt acatgctgca tcactgtagt aagctccgcc ccgtttttcc agctgcggcg 3339301 gtttgatcgc aaggtttgga tctttataaa gctcgaacag ctctttttcg accttctgta 3339361 cgacttcagc gcgggtgccc tccgtttgtg atgcttccag ttcgtgctcc agcatctctt 3339421 ttgttttaaa atagtaacgg tgatagccgc aagggatgac attgagcgct tttaagaaat 3339481 ccggttccca ttcggcgcct gagatatttt tcatcgtcat cgcgtttttc gggtcgccca 3339541 tcgcctcgat gacttgctcc ttcacactta cgccgtccaa gaaaacatcc agcccgaata 3339601 ccatatggtt cagtccggca aattggactt ctacgcggtc cacatctaca tcaagcgctt 3339661 tggctacgcc cattttgatg ccgattggaa cattgcaaag accgacgact ttcttcaggt 3339721 tggagtagcg aagcaaggct tctgttacca tgccggcagg gtttgtgaag ttaacaagcc 3339781 aagcgttcgg gcaaagctct tctatgtcct ttgcgatctc aaggatgacc ggaattgtgc 3339841 gcaatccttt aaacagacct cccgggccgt ttgtttcctg gcctatcact ccgtatttta 3339901 gcggaatgcg ctcatccttt gctcttgcct gcaaaagtcc gacgcggaat tgggtcgtga 3339961 caaagtctgc gtctttcagc gcctttctcc ggtcgagcgt aagatgaatg tcaatcggga 3340021 cgccagcttt ttcaaccatc cgtttggcga gtgtgccgac aatattcagc ttttcttcgc 3340081 cctcggggat atcgacaagc cataattcac ggacaggcag ctcatcatac cgtttaatga 3340141 acccctccac tagctcgggc gtatagcttg aacctccgcc aatcgttaca atcttcaatc 3340201 cttttgtcat atgcttgctc ccctttgctc ggtgattttt tcatataact caatgatctc 3340261 tgcagccata tccttcactg tcattgcatt cattaaatga tcctgtgcat gaaccatcag 3340321 aagcgtcatt tccgtctttt ctccgcccgc ttcattttgg atcagctctg tctgataatg 3340381 atgggctttt gacaattctt cagcagcgtc ttgaagcttt ttccgcgctt cttctgcgtc 3340441 accgcttttc gcagcggcaa tggcctccat tgcggagctc ctaccgtttc ctccgtgaag 3340501 gatgatttga aaaatgattt gttccatttc ctcattcacg cgattcactt cctttctcta 3340561 cagagccgct tctttgtcat ctgttgctgc aggcgtttgg accagctcca gatcgttttc 3340621 ttctttcagc ttctgcttat cccacattct gaagaatgga tagtagacaa caaaggacac 3340681 ggcaatatta atggcttgca tgaccgcgcc tgagactttt cctcctgtcg ccaagtagcc 3340741 tgaaaagatc ggcggcatgg tccacggcac tgcgataccc gccggtttgg cgacaaggcc 3340801 ggtgctcatt ccgatgtacg tgagtgtcac tgtgacaagc ggcgtgatga taaacggaag 3340861 taagagcatt gggttcatga cgatcggcat tccgaatata atcggttcgt taatattgaa 3340921 gatggccggg ccgaccgcaa gcttcccgag ctgcttcatt tgtttgcttc gggcgcgcag 3340981 gaacatcgtg acaaccagtg ccaatgtggc gccgcttccg ccaatattga cccagatatc 3341041 gaaaaattgc tgggtgaaaa tcttaggaag ctcctcaccg gcttggaatg cgatccggtt 3341101 ggcatccatt gcgccgtacc aaatcggtgc catgacgccg ccaacaatgt ttgcaccgtg 3341161 aaggccgcag gcccataaaa gcattttgac ggcttcggcg acaaggcttc ctccaaggct 3341221 tcctcccaga atggaaagcg gagtccccaa taaaacgctt acaatattat gaaggctttc 3341281 aaacggtgtc gcttcaacaa tcagccgggc tgcccaaatt aggaagatga cggcaaagcc 3341341 ggggattaac gcgacaaatg acttgcttac cgccggcggg acaccgtccg gcattttgaa 3341401 gactaaattg cgctggataa taaggcggta aatctctgtg gacaccattg cgataatcat 3341461 ggcgacaaat aagcctttgc ttcccatgag cgaaagcgga atcccgccgc caaccatgat 3341521 ttctttcgtc gcgccatccg gcataaacgg cacttgataa ggtgttgcta ataaaaatgc 3341581 cgcaagggaa atggctccgg ccgacaaggc atcaacaccg tatttctcgg cgagccggta 3341641 ggcaatgccg aacgcggcga caagacccat aatttcaaag gtcgcgtcga ctgggtaggc 3341701 cagtttttca gaccaggagc tgccaaacgt ttttgccata aactcagcgt atcccgggat 3341761 cgggaggttg ccaatgatga ggaaaaagga accgatgata atcaggggca tcgtgaggat 3341821 gataccatca cgcagcgcct gcaaatgacg ctgtcccgca attcttcccg ctataggcat 3341881 gaccttttct tctaagatct gattgacttt attcacatag cccgcccctc tctatgacac 3341941 atgtccaagc tgttcagctg atttcagcac ttccgcccca ttgcacgttc cataatggac 3342001 ggtattaatg acgtctaccg gaaccccctt tgactctcct aattttttga gctgcggaag 3342061 catgtaacgg acttgcggac cgagaagcaa tacatccgct ttatcgatat gattttgtac 3342121 agaatcgcct gaaactgccc aaatggtata gtcttttccc tgttcctgcg cacttttttc 3342181 catcttgctc accagtaagc tagtagacat gcctgctgca caaacgagta atatattcat 3342241 gtaaaagacc ccctagagtt tgatcaattt tgtaatgtcc tgctgttgct atcatcatat 3342301 tatgaaatcg ctttcataaa cactcagggt ttttccgcag gcaacggaaa aaaggtatat 3342361 acaggctgtc agctcagcat tttttggtca aacacatccg aaagctcttg atatgaacgg 3342421 catttgatca gctggttcat cgccgccggg tcatccaaaa tgctgccaag cagtttatac 3342481 atgctttgta aatccgcttt gttctccttt tcgacacaaa gcagacagac aaattgaact 3342541 cgctgactct cccaatcgat cggttttttg agcgtacaaa cggcccaaaa cgttgttttc 3342601 gtctgcggaa caagcgggtg cgggatggca acaagattgc caaaacacgt tggcgacatg 3342661 tcttctcttt caaaaatgga atctatgatt tcttcatcgg caaagccgca ttcgaccact 3342721 ttctgcccta aaaattgaat cacttcttct tttgagcgca gatcctcctg aaaaaaaacg 3342781 agttcttttt ttaggtagcg attggctttt tccttttcat cactcagaat agattctatt 3342841 tttgtaaagt cagttccgcc taagatggtg ttaaccttca gtactggtac agggagctct 3342901 tttttaatcg gaatggtgct gatgacaaaa tcaattgatt cgtaggacat ttgatcaaga 3342961 ctataatact cagccgttcc aagaatatcg agccgcttgc cgaaatggga acgcagtttt 3343021 tcgcgcagaa gctgggcgct tccggctccc gatgcgcata caatgataca gcgtttcggc 3343081 gggctttctg ttttttttcg ttcaatcgcg gcgccaaagt ggagagccaa atatccaatt 3343141 tcgttttcat gaatctcaat acccgtttgt tcctttatca cgattccggc aatgatcccg 3343201 gcttcaaaag cgagtggata atgttccttg atcgctgcca gcatcggatt tcgaagattc 3343261 atgccgtatc ggttgcggct gatcgccggc ttcatatgca gtgccaagcc gattttcagc 3343321 tctttgtcat gcaggatgcc aagcttcagt tcacgatcaa cagctttgat catggcaagt 3343381 gtcagctgat cggtttcctc ttctattgaa aatgtgtcct ctccgcattg tgattgtgtc 3343441 attcgttttg tgccaaggag atgcatggtg atgtaggccg tctcgtcttt cggaaacgta 3343501 acggaaagct ttgattccag ctcttttacg atggcttctg cagcctggta ctccttttga 3343561 tgcaggatat gatccatatc tttcgggaaa agagaaacat agttttccgt tctgatccgt 3343621 ttacaggcga tagcgatatg gataatgagg ttattcagtc ccatgttgga cagagggatg 3343681 cggtcgtttt tcattttttt caagatggcg gaacggatga tctcaatttc ttcttttggc 3343741 aaaatatcag ccttttcatt taaaacatct atctccgttt ctctttcatc aacaatgtac 3343801 tccgccatgc agtacctcat ctgcacctcg tccccgcgca gcttgaagcc gtaattcgga 3343861 cgtgtttcca tgacgatgcg gtaaggcagc agacgtttct ttacttcctt taaatccgtt 3343921 tggagtgtag attttgagat aaatagttct tcagcaagtt catcgagctt gagataatgg 3343981 tccgccagca gcagacgttt cataagatag gccattctct cctccggcaa taccggcagg 3344041 cccttttttt gctgaaattc atcttgcagc agtgttctga atacttgctc gtcatcaatg 3344101 cggagcttgt agccggagcc tcttacagat tgtacaaagg caccgtggcc gcttagcaca 3344161 ccttgaagtt cctttatatc attgcggact gtccgcgtcg ttacgtttaa ttgcgcggca 3344221 aaaaacgaac ttgtcaccgg ggcttcagcc gccatcagca agcgcagaat atcacgtagt 3344281 cgcccatgaa gcatgagaaa aacctcctaa ctagtagatg cagggattca gtgaataggc 3344341 agaaaggatg atgaagggat gcgaaatgta tataaattct ataatggaga gaatggcaag 3344401 tcaatgaaca tccggaggac tagagggaaa actgacctat aaaaaaacag ccgggatcag 3344461 ccggctgttc tagatgcgga catattcttt tgtttagacg ccttgcggtc cttcatgatt 3344521 tttcgaacaa tcgggtaaat gaccggcgcc catttgataa cggttttgat catctttttc 3344581 aaagctccga ttctcccttc ttttttctca accattcccc tgattgcctc ttccttaaac 3344641 atgctaacgc gacacgtacc tgtttcccgt cacccagaaa cgccatggat aatcgcgtgc 3344701 ctccccgctg ttgtcaatgc cgatgcgcgg gccggttgaa attgcttccg gtgtgtaccc 3344761 gctttcgatg taaagcggct gttccgtgat ccagcgtccg tagtcattca tcgtgacgcc 3344821 aagcgctttc gtcagctttc ctggtccgtt tgtccattcc ctcggactcc tgcccggcct 3344881 tctctcctcc attaacagct ggccttcatg cggctcaatc gccctgatta atactgcttg 3344941 cgggacatcc tcttccgccg caacgacatt cagcaatgta tgggtgtgca tcacgtatgt 3345001 atatacccgc ccagcttctg caaacatgat ctcagtccgc ttcgtccggc ggttgttaaa 3345061 gctgtgggcc gctctgtctc cagcccccat ataggcctct gtttccacaa tatagcctga 3345121 cgctgtgcct tcgtctgttt cttttacaag aaggcagccc agaagcgatg gggcaagctc 3345181 aagagcggtt ttttgataaa acgtgatggg cagcggattt ttttctctcg tcacgaatcg 3345241 acctctcctt ttaccgattt ttgtacattg taccattccc gaagcagatc aaaaaaaacg 3345301 gctgttttaa aatctttcca ttcagggaat attgttaccg ttcaaaaaag gagggccaac 3345361 cattgaaaga tgatcatcaa aacaagcagc accaatcaaa tgcccaaggg agcgaggaag 3345421 cgttttctca taagacatcc gggaaaaacg agtcagagga taccttaacg aataggcagg 3345481 ggcatcctgt tactgacaac cagaatgtga gaaccgtcgg gaatagaggg cctacaacac 3345541 ttgagaacta tgattttctc gaaaagatca gccacttcga ccgggaacgc atcccagagc 3345601 gggttgttca tgccagggga gcaggtgcac atggatattt tgaagcgtac ggaagcttcg 3345661 gagacgaacc gatttcaaca tacacaaggg ccaagctctt tcaggaaaaa ggcaagaaaa 3345721 caccggcatt tgtccgtttt tcaactgtga atcatggaaa acactcgcct gaaacattga 3345781 gagacccgcg cggttttgct gtaaagctat atacagaaga cggaaactgg gatttggtcg 3345841 gaaacaacct gaaaatcttt tttatccgcg acccgctgaa atttccggat cttgtacacg 3345901 catttcagcc tgatccagtg acaaacatcc aggatggtga acgtatcttc gatttcattt 3345961 ctcaatctcc tgaagcgaca cacatgatca ccttcttgtt ttcgccttgg ggcattccgg 3346021 ccaactaccg gcaaatgcag ggttcaggcg tacatgccta taaatgggtg aatgaggagg 3346081 gcaaggccgt tctcgtgaaa taccattttg aaccgaagca gggcatccgc aacctgacac 3346141 agaaggaagc agaagagatt caagggaaaa actttaacca tgccacacag gatctatatg 3346201 acgcgattga aaatggcgat tatccagagt gggaagtata tgctcaaatc atgagcgatg 3346261 atgagcatcc tgaactggac tttgatcctc ttgatccaac aaaactgtgg tataaagacg 3346321 atttcccatg gaaaccgatc ggcaaattgg ttctgaacaa aaatccggaa aactaccatg 3346381 cggaagtgga gcaagcttca tttggaacgg gagtgcttgt cgacgggctt gatttttcag 3346441 acgacaaatt gctccagggg cgtacgtttg cctactctga tacgcagcgc taccgtgtag 3346501 gcgcaaatta cctgcagctt ccgatcaact cgccgaaaaa gcatgtcgcc accaaccagg 3346561 aaggcgggca aatgcaatat cgggtcgata gagcagaagg acaaaacccg cacgtcaact 3346621 acgagccatc cattatgggc gggctgaagg aagcgaagca agacggaaaa gaccatacgc 3346681 cgcatgtcga aggtgatgta aagcgtgaag cgattgacag aacaaacaac ttcggacagg 3346741 ctggagaaac gtaccggaga tttactgaat ttgagcggaa cgaattgatt acgaatttgg 3346801 tgaatacgct ttctacgtgc cgaaaagaaa ttcaggatca aatgattgag aatttcacaa 3346861 aagctgatcc tgactacgga aaacgcgtag cagaagggct aaaaaaggtc tccgaaaaca 3346921 acagcaacgg gccgatcggc acaactgaaa cggaacaggc tgcaaagcag gctgaacagg 3346981 agagtcatcc gtctgatccg tattaacaac agcgaacagg gcttttttag aagccctgtt 3347041 tttttatttt tctattgaaa cgctttcaat aattgtgttg tacttggaag gaaaggggtg 3347101 gagagatacg atggaattac agcaggactt gattcctcag aaaaaaacaa tcggcgcttt 3347161 agatcacgcc gtttttttat gcatggtatt ttgtttctgg ttttcaggct atatttacgt 3347221 tcctgtattc agtctgtatt tggaggatct gcacttttca tatggcgcaa tcggcatcat 3347281 tctcggcagc tacggggtca cgcaaatcct tctgcgattc ccgctcggcc ttttgtcaga 3347341 catcctgttt tccttgcgca agcaattgtt aattgccggg ttcggctttt ccgtcctcag 3347401 cagcctgctt tttctgatgt ttgattcttt cttcttcgtg ctggccgccc ggcttttcgc 3347461 gggaatcact gcttctacgt gggtgatggc gaccatttta tacgcacatt atttcaacaa 3347521 tggcaatgca tcaaaagcaa tgggcatcat gcagtttttt accgtcatgc ctcagtttgc 3347581 cagcattgtg ttctgcgggc tcgccgcagc ccatttaggg aggcaggttc ctttttggat 3347641 ggcgctggca gcttctgccg caggtctggt gatctgctgc tttattcagg atccgtctgc 3347701 tcctcccgca aaccgtggca ccattcgtgt caatcagtac atcaaagata cattgcggct 3347761 gccaaagctg aagcttttca ccatcctgtc tatgacggcc catgccgtat tatttatcac 3347821 agtgtttggt tttacgccgc tttacatgaa tcagctcgga atgggcgacg cggagctgct 3347881 ttgggtgatg agcgcctttt tcctcccaca cgcagccgcc acattaagct ttgtgtttct 3347941 gcgctttaca agccgtatcg cttactccgt gatgctcatt agtttcgctg tcaccggggt 3348001 ctgtttgcta tatgttcctt ttttagctgc attgttcacg gtttgcatca cacacgcctg 3348061 tattgggctg gcgctcggct tcgtttttcc tctgctgcta agccatgtcg tcgaaatcag 3348121 ttctgcccgt ttaaaaatgt cagtgatggg gttttaccaa tcattttatg cgctaggcat 3348181 cttcctcggg ccccttcttg ccggaaaaat cgcacagctt atcgggcttg cgggagtttt 3348241 ttatggagcc ggttctctgg catttgccgc cttttttgtg atgctcgcgc aaaaacgtaa 3348301 catgatcaat taatagcttt cataccgccg gaagcgccac acagaaaaca cggccagaag 3348361 catgatgcac agaatggaga aagtgagtga ccatccgaaa aaatctgccc gctctccatg 3348421 aagaaggata tgctccgcct gcttgcaaat ctcagccgga agccacttcg caccatctgg 3348481 aaatagtgaa acagcaaagg aaacggctgc tgtgagcccg atcccgcaag ccgcagctgc 3348541 tccgacagac cggaatatcg tacttccggc aaggccggcg gtcacaataa atatcaccca 3348601 aagagcgtaa aggccaaggc ttgcggcaaa gcggctgaat gatgcgtcct caaacagcag 3348661 ccggacgtaa tagtaagcaa gcccgtatcc agctgcaaac gacataatgc cgatcacgct 3348721 ttggatgagc catttactca cgatataatg ggctgccgtc acaggccgcg acataatcag 3348781 cgctgttacc ccttgatttc tttcattggc tacactgccc atcacgctaa agatgaccag 3348841 agccatgcca agcgtgttga attgagaaag cgtgctgacc atcacttcag acccggaggg 3348901 catcgtaaaa ctgattttca tgccgtcagg aaggttccct ccatgtgcga tgatttccgg 3348961 catataataa atggtcagcg gctgtgtcag cccgacgatc atcatcgcaa tcggcagcca 3349021 aatcagcttg ccgcttttcc atccttccag ccactccttc tgcaatagcg ccatcatcac 3349081 cttcatgcgt gcaccacctt tagatagacg tcttctagag actccgtttt ctgttcaaag 3349141 cgggtgacgg tcaatccctt tcggatacag tcacttaata atgaccggcc agcgtgtata 3349201 tcaggcagct cgaaaaccgc ttgggacgga ttcttataga caatagctga gacgtaaggc 3349261 ttctcttcaa gccaaccttc cagcttctct ttcactgaaa gggtaaaaac gttcgtttgc 3349321 tgctgttgtt tcagctcctg taactcgcct ttccatgaaa tctcaccgtt tttcataatc 3349381 accacttgat cacacacctg ttctgcatcg tgcaaaacat gtgtagaaaa cagaacggcc 3349441 atatgctttt tcagctcccg catcatgtcc agcacctcga accgtcctgt cggatcaagc 3349501 gcagacaccg gttcatccaa tatcaaaaac ttcggtttat ggagcagtgc ctgtgccaga 3349561 ccgagtcttt gtttcatgcc tcctgaatag cccccgatcc ttttgtgcgc cgcttcgtgc 3349621 aaaccgacaa attccagcat ctcgccgatt ttctcttggc attttctctt cgaaaggccg 3349681 gacagtctcc ccgcaaatgt caaaaattca tttgcggtca tccacgaata aaaagcagga 3349741 tactgcggga ggtacccaat caaacgccga tccagctttt tctctcctaa cagctttatg 3349801 gttccagagg ttggcgaaag cagtccggcc agcatttgca gagtcgtggt tttgccggct 3349861 ccattaggtc ctaatagtgc gacacactca ttttcattca cgtgaaaact gacattcttt 3349921 acagcttcat ggtgcctgta cgatttgcat aatgattcaa tagacagcat atcggcttac 3349981 ctttgctttc tgccgacggt gaaaaataaa atcggcccga taatattgat acatacgatg 3350041 attgcagccc acatccactt tggcccgttc gtccgctctt cttttataca gctgataagg 3350101 gcaaacaccg ccaaagccag ctgtaataca atcagcggca aaatcatttc ccaagaaata 3350161 ttcattgctt gatccccctt ttcttccgat ccggcctaat gacaaaaaag taataacaaa 3350221 tcagaggcat cggtgcttga atcaatccga caatccccca aacccatgcc atgtgattac 3350281 gttttttcgc atcaataaat aaaaagattc cctgcgccaa tacgatgaga caagccgcaa 3350341 ccgttatgat aatttctgtt tgtgtcatcc gcgtttcacc tcgcattcgc cgagatgcct 3350401 ttttttctca gccgcaatca aaatcggcag caccgcaagc acacaaacct gaagcacaat 3350461 aaacacagca ggagcttgag tgaaagctaa gattgcagca ctcacaacca tcagcgcgca 3350521 gaatacaaat aaaatgatct cttgaagaag tttttttctg tattcagctt tcatttgtga 3350581 cagctggtga agcagttctt tttgattcgg tatagaggga ttggctgttt gatcaatttt 3350641 tttccattct gactttaaat gatcagaaag cttttcttta ttcatcatcc cactcctttc 3350701 tgatttgctg gagcccttta tgaactctgg actttacagt gccttctttg atttgaagca 3350761 tcaccccgat ttcagcgtag gtatagccgt agtaatgcct taataaaacc ggtgtgcgca 3350821 gtttagggtc cagctttgaa aacagatcga gcgtttcgct ccactctgcc cctttcgccg 3350881 acacgtccca cttgatcttg cggattgttt cctccgtaac tgtctgattc cgtttccatt 3350941 ctctctttct ctttttctgg tgatcgagat agagccgcga tgcaatggag atcagccatg 3351001 tggagaattt tgaacggccc tgaaagcttc ttaaatggat gtaccctttc agaaaggttt 3351061 cctgaacaag ttcctcgctg agatcggggt gaagggaaag ctttaacaag tatttatata 3351121 agaaagaata gtgatagtgg aaaagggctg taaacgcctc gtcgtttccc tctttcgcct 3351181 gctggatcag ccgctgttct tcttgtgtat ccaatgaccg tgatcccccc ttttttgttt 3351241 ttctgcctta tgagacgaca ccggattcaa aagcgttcat cttttttaca attcttttca 3351301 gccattgaca gatcaggctt cccggccgtt tggctgcata tccttatttg taaaccccct 3351361 tatagtctgt taagctatga ctttatgtcg atttcaaaaa aacatccaat atggaggacg 3351421 atgcattgaa agtagaaagg cgaacgattg aatatattcc gaatgaagaa agacatggta 3351481 aagcgaaaga tttatttccc gtatggttcg gggctaatat gcatatcacc acgttagtga 3351541 ccggcacgat tcccgttgca atgggactta atctgttttg gagtgttgcc gctattattt 3351601 gcggaacctt aatcggtgcc atatttatgg cttctcattc cgcgcaaggc cctcagctag 3351661 gcatcccgca aatgattcaa agccgtgccc aattcggcgt aatcggagcg attcttcccc 3351721 tcttcttagt catgtttatc taccttggtt tcttcgcaag cagcacgatt ctggcggccg 3351781 gaaccttaag cagctttgtt cccatcccgg gatcatggag cattataggc ttaagtgccg 3351841 tatgtttttt actcaccatt ttcggccatg atttgattca caaaatgcaa aaaatccttt 3351901 cttggacctc ttttgctgta ttttttgctg caacgattct catttttcaa ttgccgattc 3351961 cggcaggcag ctggataccc ggagcgattg atctgccaat tttcctagtg gcagtcagcg 3352021 cagttgcgac gtggcagctt gcctacgcgc cgtatgttgc cgattattca agatatctgc 3352081 cagttaaaac accggcttca aaaacatttt ggtacagcta tgcaggtaca tctgtcagct 3352141 ccatctggat gatgctgctc ggcgcattgc tgacaacctc acttcctgac tttacggcaa 3352201 actcaggcag ccagattgtc caattgttcg gtcccttctc gtttattatg ctgatcattg 3352261 tgctatttgg gcaaatggca atcaatgttt ttaacctgta tggggctttc atgtccacga 3352321 caacaacgct ggagccgttt ctgaaattaa aagtcacgcc caaagtcaga atcatcatga 3352381 tcctgggtgt cacgcttgtc ggcacagtct taagcctact gggacagagc aattttatgg 3352441 aactgttttt gaattttatc tttttcatca gttatttctt aattccgtgg acggcaatca 3352501 atttagtcga ttactacttc gtccgccacg gaaagtatca agtcaaagcc atgttcgacg 3352561 taaacgggcc ttatggaaag gtcaattgga tcaccacaat tgcgttcgtt ctgtctatct 3352621 tgctggaaat tccgtttatc aacacaagct tttacatcgg accgcttgcc aaaatgtttg 3352681 gcggcggaga catcgcatgg attatcggct tggccgtgcc ttctgtgctt tactatgtat 3352741 taatgaaacc gcgtctgaaa aaacgggcgg ggtatcaaga aaagctgtct tctctctgaa 3352801 gacagctttt ttatcattca aatcgtttcc acacgcgggg caggatgtca gatagctcat 3352861 gagcgagcaa cgtatgagcg gagtgctcgt ccgtccagag ctcggcgcac gcaccatgca 3352921 aatagaccgc gtttaatacg gcgtgctttg gatcttcatg gcagcagagc atccccaata 3352981 tcatgcccgt cagcgtgtca ccggttccgc ccttggcgag cgccccgttt ccggttggat 3353041 tgagccagca gtctccatca ggaaacgcga tgacggtttg gtttcctttt aacacaatga 3353101 cagtctgcag ctgagccgcc cattcctttg catattccgc tctttttttc tgcaattcgt 3353161 tcacgggcac ccctgtcatt cggaaaaact cgcccgggtg cggcgtgagg atgacggggc 3353221 cctcccgttt cggatatgtg cgcttcgcca gcgctccggc atccaaaata acaggacaat 3353281 cagccgtaag cacatgatcg actgcctgct gtacgctttc cgtttgcgga aggcccggtc 3353341 cgatggcaat ggcccggtac gtctcttcaa gctgagcatc cgccgccttt ttccagccgt 3353401 cacgccaata ggtcgcctcg ggcaaaacag gaacaattag cgggattacg ttttctgatg 3353461 taccgatgac aagcttgccg agaccgctcc gcatggcccc aagccctgca agcagcgctg 3353521 ctcccggcat gtcgtcactt ccagccagca gcaaagccgt accgtacgtg cctttatggc 3353581 tctccgcatc tctttcagga agcgtggccc ttacatgctc ttccgtccaa aatggaacat 3353641 tcatctctat ccctcctctg ctttcttttc ctatttttcc tgtccctttt ctttttcaaa 3353701 caaaaaagac agccttttag ggctgtcttt tattttacag gaacatcaag gtgatacagg 3353761 cggcgatatc gttcgtttgc cgccagcagc tcctcatggg ttccttccat ttctgttttg 3353821 ccgttttcga gaaatacgat tttatcggct gcttccactc ccgcgagatg gtgtgtaatc 3353881 cataaaatcg tttttccttt cagcacctca aacaccgttt ccatcaattc acgttcggta 3353941 ataggatcga ggccgactgt tggctcatcg aggatgatga tcggtgtatc ctgcagcaaa 3354001 atcctcgcaa gtgcgatccg ctggcgctct ccaccggaaa aacggatgcc ggtttcttgt 3354061 acagaggtat gatatccgtc aggcaatgac tcaatgtagt catgcagctt gacctgcttt 3354121 gcggcgcggc gcacatcctc gtcgcttgct tctccgtttc cgagcctgat gttgttcaaa 3354181 atgcttgtat caaacaggtg cggtttttga tttaacacgg ccaccgcatc cgcaatctga 3354241 tcctttaaca gcgctgtctc cactccgttt aacgtcacag aaccggagtc cggtttcaag 3354301 gcgccttcga ttaatgcaag cgatgttgat ttcccagagc cgcttcggcc gagcagcgcc 3354361 attttttctc cttggcgcag cgtaaaggaa aagttgtgca gcacttggct gctgttgtca 3354421 taagaaaacg tcacatcacg aaaggccaag gtgacatctt gaagatcgag aatttgatcc 3354481 cctgattcag tttgtgacgc ctccggctga ggagccacat tgttcatgcg tctgatagaa 3354541 tcctgatagc ccggcacttc gcctaaggca tccgaaagcg gcaaaaaggc ttccgtcaac 3354601 ggaaacacca ctagcacaaa agcggcaatc atcgttttag cgagctcgcc gtccgcttgc 3354661 tgtcccgctg tccaaaacag catcagcaaa ataaggccag cgacaaggca ttgcgcagca 3354721 aagtcccgcc atcttgtaaa gcgttgtttt ttccgttcaa gctcaaacca atcacgttcc 3354781 tctttttcat aagcatcaat aaaagcatgc cggcgtccgc tgaacatcca gtcgctgaca 3354841 cccatcacag catctgtcag acggctgtac agcacattcc gtccgctttt cagcttcgca 3354901 ttcttcgctc tcgtcacgag caaagacaca accggaaaca atacaacaag aacaaacaaa 3354961 tacagcgcaa gcaatatggc aaacggccaa gagaagaagc cgagcgctat cactgacaca 3355021 gcatacagga gcaaggctga gatcgcagga aaaatcgttt ttaagaaagc atcctgcaaa 3355081 tgctcaatat cctcagacaa aatgccgagc atatcccccg tgcgaaaacg ggaacgcagc 3355141 atcaaagcac ccggctcaag catattgtaa aggcggacgc gcatgtcaga tacgattttc 3355201 aaaatgatgt gatggccgac gagccgttcc acatatcgcg acacagagcg cgcaatccca 3355261 aaggtgcgca cagcgacaat cggcacataa atgagcagaa tgttttccgg ccttgtcgcc 3355321 gctttagaaa tcaaaaaacc tgaggtgaac atgagaaaag cagcagaaaa aatcgtcacc 3355381 gcacccaaaa agataaccag aacgaacagg cgggcatttt gcttgatata cggcaaaatc 3355441 cattcttctt tcttcatgct ctttccccca gttgtgcctt cacgagtttg gtatacacac 3355501 cgtttttctc cagcagttca ttgtgagtcc caatttccgc aaccctgccc ccgtcaagca 3355561 cgataatttc gtccatatcg agcatccagt gaaggcggtg agtcgcgaga aagacgagct 3355621 tatcctcaaa taaatccagc atcgtttctt ttatttcata ttctgtttcg atatcaagat 3355681 gggcggtcgg ctcatccagc agcaggatcg gacggtttcc caaaaaggcg cgggccagcg 3355741 cgacacgctg tgcctggccg ccgctgagcg cccggccgcc ttccccgatc cgcccctcta 3355801 atccgtcagg aaggttgttc accagctccg tcagtcccgc tgaggcagca gcacgtgttg 3355861 tatcctctgc cgaagcgctt ggatggtaga agcgaatgtt gttgccaagc gtatcatcaa 3355921 aaatgtacgg atgctgggga atgtaaagaa ggttcttctg ccagctgccg tcctgcaaat 3355981 gggaccggct tgtaccatta acctcaatca tcccgccatc cggctctaaa aatccgccga 3356041 gaatatcaat taatgttgat tttccggcgc cgcttgcacc gataatgccg atttttttct 3356101 tgcctttgaa tgagagatga atatcagaca ccgaacggcc gactgacacg cctgacagct 3356161 tcagctcatc ctgatcggac caagcttcga gctgaagcgg cgtctcttct ttaaaaccag 3356221 gctgcgacaa aatctcttga atggtttttc ctgcttcctg gccgttcagc gttgcatgat 3356281 aatcattccc cacttcccgc accggcaaaa aatactcagg cgccagaata agcgccgtta 3356341 aagcagggcc aagcaaaata tcgccgtcaa tgaggcgcag gcccagaaat actgcgactg 3356401 tcgccaccga cagcatcgtg aaaaaatcga gggcgaatga tgacaaaaac gccacccgga 3356461 gtgtgctcat cgttgccttg cgataccgct cactcacata gaaaatattt ttgctgtgtg 3356521 acttgctcaa acctaggaaa cgcaatgtct ccagcccgcg aagagaatca acaaaatgat 3356581 tggaaagtct ctgataggat ttccactgac gatccgcttt tctctgcgcg acaaggccga 3356641 ggagaatcat aaagatgatc agaatcggca tagcagcgac taaaatgatg gctgatgtcc 3356701 gatcctgaaa aaacacataa atgacaactg ccgcaggcac aatcgccatg ctgaccattt 3356761 tcggcagaaa cagctccagg tagcggcgga actggctgat gccttccatc gccagcgtca 3356821 ccatttgccc cgtcccctct ttctttgcaa agcgggggcc taatcggaac agctgatcaa 3356881 gaaaactttt cctcaaatct gctcctgtcc gggcggcgta ttgatagacg attttctgtc 3356941 gcgccaccgt catcccgtgc cgggcgataa aagcgatgag gaaaaagccg atcaccggta 3357001 aaagggaggt aatgcccttc ccgttgaaca gtccggttac ggcctcactc agccactctg 3357061 cctgcataat aatggcggct gtctgaatca acgttaaaca agtaatcaag gtgagaatcc 3357121 gcttcattcc tttatatcga aacaggtctt ttcccattaa taagtcatag gctccttatg 3357181 gctgacgcgc ttccggaaga cataatagct ccagatctgg ctgccgatga cgaacggcaa 3357241 tagcgttaat gctgcaattg acatgacttt aagcgaataa tctccagaag aagcgttagc 3357301 tactgttaaa tcgtatgcgc tatgaagcga gctgaccatt acacgaggga atagggaaat 3357361 aaagatcatt cccacggtca gcgccagacc agcgcctgtc atcccaaatg tccagccgtc 3357421 ttttttctta cgaataaata cagccgcgag cataaagcag atgacaatca aaacagcgag 3357481 cggaatggta atctcgccgc ggcgtgtaaa catgtctgtc tgatacgcag aaagggccgc 3357541 gaaggcaaga accgctacaa aaacaacacc cattatcttt tgcgccattt tccgggcgcg 3357601 gttttgcaaa tcaccaatcg tacgcagcgt gataaacatt aatccatgct ggaagcaaag 3357661 aagcgttacc gtcacaccgc caagtataga atatacattg atataatcag atacatgtgc 3357721 gtgaatgttc atgtcggcat caatcggcat cccgcggaat aatgtcgtga acagcacacc 3357781 aagcacaaac ggaggaatta gactgccgaa aaaaacgacc cagtcccaaa cctttaccca 3357841 ttttaaatga tccaccttgc cgcggaactc aaacgcgacc ccgcggccca ttaacgcaag 3357901 cagcactatg acaaacggaa tgtaataacc gctcagcatc gttgcatacc agtttgggaa 3357961 tgccgcgaaa atggcgcctg cgccagtcaa aagccacact tcattcgcgt cccagaacgg 3358021 cccgatcgtg ttgatcagca ctctgcgttc taattcatta tggccaagaa aacgggtcgc 3358081 catgccgacc ccgaaatcaa agccttccaa aaagaagaat cctacaaaca atacagcaac 3358141 gagtataaac caaagatcat gaagagatgc catggtatac ctcctgacta aatggatctg 3358201 ttgatacagg cacatcatga tgattatcat gctccgcacc ttttttaatc tcacggataa 3358261 acaagaagac aagcagtgca ccaagaatca tgtacatcac accgaatgcg atgattgaga 3358321 ataacaagga acccgctgtt acgttaggcg acacagattg agcggttgtc attaacccca 3358381 taaccgtcca aggctgacgt ccgatttctg tcataatcca gcccgcggag tttgcaagaa 3358441 acgggaagga aatcaacgcg atcatgatgc gcaaatacca tttgctgttt tcaagctttt 3358501 tacggcggtt taaccaaagg ccgcctaacg cagcaagaat catgacaaca cctgctccta 3358561 ccatgatgcg gaagctccag aatgtcgttt tcactggcgg aatgtagtcg ccttttccgt 3358621 atattttttc gtactcagcc tgaagggttt tcatcccttt gacacttccg ctgaatttct 3358681 gataagccaa gtagctcaag gcataaggaa ctttgatttc atttgagctt ttttcatttt 3358741 ttgtatcgat cgtcgcaaaa gcggtccaag cagcagggtc accgctgtct tcccataggc 3358801 cttcactggc agccattttc atcggctgtg attccatcaa gtgctcagcc tgcatgtgtc 3358861 cgctaaggcc gacgccaaga ccggcacaaa gaccgacgat cattgcgagt ttaaaagatt 3358921 gcttaaagaa cggcacttct tttttcttca gcagtttaaa agcactcact ccggcaataa 3358981 agaaagctcc agtggcaagc gcaccgaaaa taacgtgcgg gaattcaacc caaagctgag 3359041 ggtttgtaat caacgcgcca aaatcattca tttccgcgcg gccgtttttg atcgtaaagc 3359101 cgaccggctc ctgcataaag gagtttgctg ttaaaatcca gaaagatgac atgatcgttc 3359161 cgaatgatac gagccatatg cagagcgcgt gaattttctt cggcaggcgg tcccagccaa 3359221 aaatccataa tccgataaaa atagattcca tgaaaaacgc caataatgct tcaatcgcaa 3359281 gcggagcgcc aaatacatct ccgacaaaac gggagtaatc tgaccagttc agtccaaact 3359341 ggaattcttg caaaatcccc gttacaacac cgactgcgaa atttattaag aataagtgtc 3359401 cccaaaactt tgccattttg agatacagct catttttctt tacaagataa agagtctcca 3359461 tcaacgcaac cataaacaca agcccgatag acatcggcac aaacaagaag tgaaacaacg 3359521 ttgttgatgc aaattgtatg cgggctaata ccaattcact catgctttct cctccatttc 3359581 cggttaaaac tgttaatttg ctcactactt cacaaataga accgagactt tgatcagtaa 3359641 ttcacaaaat agacgaaaaa aatattgctc aatatttcac aaatgtgtca aaaagtcatc 3359701 caatatgatg caagattgcc agactgacca aatgacacaa tctctgactg gttcatatta 3359761 agtactttac aacgattcat ttcaaaaata aagcctaaaa tacctaaaaa gtcccgcact 3359821 atgtgacgga tttttgtcta ttttgttgct tatttatgtc ggctgctagg ataaatgacc 3359881 ctttattatc gtacatcaac acatcgttcc ttgcgaacaa aatgcttgcc cccgccccag 3359941 cactcgagtc tcagcattcc gtcttaaacc gattttagtc agaatgcctc ttttcatttg 3360001 aaccggtaag aggagaaaag ttgaatagta aatttttaat atattaataa tttcaatttt 3360061 ttagtatact taacatagtg aacaatttca ctgcatcaag aataggggag gtttttcaat 3360121 gggagagctt caaacacaca tgcaattgca aacggataca attcacgaag gggttcgaaa 3360181 agagaattgg tttgcgaaag ccatgaatat aaaagtaggc atcataccgc ttcctgtgta 3360241 tgccttgctg tttatattaa tcactgtttt tgttatgcat cacgatgtaa aaagtgacat 3360301 tttgacatcc attgccgtca tggcgttttt cgggtttacc tttgcccaaa tcggcaaatc 3360361 gataccgatt gttcgttcta tcggcggccc ggccatccta gctactttta ttccgtccgc 3360421 tgtcgtgtac tatcacctgc tgcctaatga tatcgtcaaa tccaccacag aatttacaga 3360481 aaactcaaac tttctatatt tgtttatcgc cggtattgtc gtcggaagca ttctcggcat 3360541 gaaaagagaa acactcgtaa aagcattcat gaaaatcttt attccgctta ttgtcggttc 3360601 tgtcacagcc gctattgtcg gactggctgt cgggacattg ctcggactcg gatttcagca 3360661 taccctgctg tacattgtca ttccgatcat ggctggagga gtcggagaag gcgctatccc 3360721 gctgtccatc ggatattctg acatcatgcc catttctcaa ggggaagcgt ttgcacttgt 3360781 tctgccatcg attatgctgg gcagcttgtg cgcgattatt ctagcgggat tgctgaaccg 3360841 aatcggaaag aaaaaaccgg aatggacagg caacggcaaa gtggaccgct ccgaagaaga 3360901 gtcccctgcg ctggaggaat ctcaaagcgg acagcaaatg ttcaaccttt ctttatttgc 3360961 gtcaggcggt atccttgctg tttctttata cttagtcggc atgctcgctc acgatttttt 3361021 cggttttccg gcacccgttg ccatgctgtt actggctgtt ctaatcaagc tgttcagatt 3361081 ggtgcctgcc tcaattgaaa atggcgcgtt tggagtgtcc cgcttctttt caacagctgt 3361141 gacctacccg cttctctttg cgattggggt atccatgacg ccgtgggaca agcttgtcgc 3361201 cgcttttaac ctcagcaata ttatcacgat tctgtctgtc gttgtgacca tgatggccgt 3361261 tggcttcttc actggaaaat ggctgaacat gtatccgatt gaaaccgcca ttattaatgc 3361321 atgccattct gggcaaggcg gcacgggtga cgttgccatt ttaagcgccg ctgaaaggct 3361381 tgagctaatg cctttcgccc aggtgtctac ccgcatcggg ggcgcgatta cagtatcctt 3361441 aaccttattg ctgctgcacc agttttattg atccccgcaa gcaagttctt cgtcaaacga 3361501 aagagcttgc ttttttgcat gtccatgttt ttgcaagttc ccatcccatg ctatagtaat 3361561 agttggaaat actagataga aaggaatctg gcatgcctat gggaactcat ctatttctct 3361621 ttatgcttct cgggctggga ttttatttga tatcagccct agctgcaaaa ctcattccgg 3361681 ccatagactt ctggattgat attgttctat gggtcggcgc tgcggcttac atcttctctc 3361741 atctctcatt catggacggc attgtctcac tcgcgacaat gttctactgc tattggaccg 3361801 caatggatct cattgtttca gagcgtgtgg aaaaaccttc gggagactgg caggaaatcg 3361861 agcttgccaa aaacaaaaca cgcctcctgt cagacattac gctgaccgcc attgtgtttg 3361921 caggggctgt catttttttc atctatggac ctgacacaag ccctctcaaa tatgtgatcc 3361981 ttctcggaat gatctccggc ggaggggcac ttgtgaagcg aatactgaat gtttttagcg 3362041 taaaggtttt ttattcagca gccttagaaa aattgcatat cagctcacac tatgaaaccc 3362101 gtacataccc gctttccgat ttgaagaaca ttcagcttga atcaacagca gatctcttaa 3362161 agctccatcc gcttctgacg atgtattcat cccgtttaga tttgacaaca agctttcagc 3362221 aagtcattaa actgtctctt cccggcgaaa cactgtttct gacggtgaag gaaccgcaaa 3362281 aatggaaaac aattcttcag gaatacacag atgcagaaaa caatgtggac aatgtgattt 3362341 ctgttttgcc gttttatcat cgaaaaaatg tgaagcggct gctcggtaag ctttattttg 3362401 ccgccagcgt aaaaggggta tccgcttacg ccttattggt gctcgcgtta tacgcattac 3362461 acgcctctcc atgggtcatg gctgttgccg taatcctata ttgggtattc aacatgtata 3362521 tgtcagaccg tgtgttgcgg gcggcgatgg acgccaagtc ttgtcatcat ccgcatgtac 3362581 aggccgcggc cgataagatt ttcagatcgg ccggcatttc ccatgtccgc atatacgaaa 3362641 cggagagtga tgattacaac ggaatggcag taggcatgaa tgtcgggagg tcaatggtca 3362701 tcctgacaag cgccacacta acacttccac agcgtgtcat tgaaggcatt ctggcccatg 3362761 aggcgattca tatcaaaaaa cgtgacgttc tgtcatcaca gcttttgcgt tttctatatc 3362821 ttggagctgt cgtggggatt ttcctcttgt ttgagcagca tatcacccat cccgaggccc 3362881 acaaaattgc gctttgggct ttcattatgg caatcattat cctattccag ctctatcaat 3362941 ccttttgttc acaatggatg gaggtgcgtg ctgacaacct tggcgcatca ttgctggacg 3363001 gcggttacaa acaaatggct gaagccttga gaatcttggc ggttcggcaa gatgaggata 3363061 tacagaaaca aagtgcctat agctctgaag caggtgaaga cgagcttcaa attgattctc 3363121 tcacccgtga taaaagctgg tttttcagat tgattgattt tcagttcgct cctcatcctc 3363181 ctatgtattg gcgtgtcggc actttattgt caaacaaagg acatggggtg ctaaagcgct 3363241 ggctcagaga ccgactgaaa gaatcgatca ctttgaaatg aaaccggtca gcgtttcatc 3363301 cgtataacag atatggtgaa aaaagggagt gacgcgaagt gattgtgatc atcttattgt 3363361 ttatatctat tattgttttt ctttcagtca ttcagccgca gccctcgaaa aacaaaagcc 3363421 gccagcaggc ggacagcggg tatttcggtt attcagatca tagctcacac catgatggat 3363481 gcagcagtga cggaggtttc agcgattccg gctgtggcgg cggagggggc ggcgattaaa 3363541 cgccgccttt ttttatttca ttgattcgat gtacgcacca aaagccgagc ctgacatgcc 3363601 tggggacacg cgcacacgat ggagggcata cattccctgg tctctcgaag ccgcgcccgg 3363661 ttctgtcgtc acgcccattt gatagcctgt tttttcagcg gccttcagcg tctcctcatt 3363721 gtagcgccct accggatagc tgatgatggt ggtttgctga tgaaacatgt tgtcgaacag 3363781 ctttttcgaa tcagccatct cactttgctg ctgttgaggc gttaatccgt tcagctcaag 3363841 gtggtcaatc gtatggcttt caatcgatat gccgtgctgt gccatttcct tcatttgttc 3363901 ctctgtcaga tggtgcttat gtccgatcga tttgccgatc ataaaaatcg ttgccttcat 3363961 cccgtacttt ttcagcaccg gatacgcatc ttgataattg tcggtgtacc cgtcatcaaa 3364021 tgtgatcagc acgcacttct cactcggttt tttatcctgc gtcagcatga gagatgcctc 3364081 tttcggcgtt aatgtctgat agccgttatc atgaagccac ttcatatgcg cctcgaattc 3364141 tttctttggc acacggaggc tgtttcctga agaaatgctg tggtacatca aaatcggcag 3364201 ctttgccggt ttctctgttt tgatccatgc ggatgtatcg tcttcttttt tctgaacttg 3364261 tactgccttt ttttccggtt tcttttgttc cgcttttggc atcggctgct ctgcattcgc 3364321 ctcttgatca gcacaagccg caagagccaa acagctgccc aaaagaaaga tgcttaaaaa 3364381 caatcgtttc atcgttctcc tgctttctgt ctatttcttc ctcctttttc atcggtttga 3364441 ttctgagatt ttcaatagca aaaaaccgga catgtctcca tgtccggttt ttttgatctt 3364501 atcggattct cacttctgtc tcactgtcaa agaaatggcc tttattcata tcaaatgcaa 3364561 ccgtcagctc atcgcccgat tgaatatcga ggcgggcgtc gatccgcgca ataaagtctt 3364621 ggttgtctat ctgcgaataa atcataattt cagaaccgag cagctctgca acattaattt 3364681 tcgccttaat cgaagagttc ttatatgatt ccacgacaat caattcatca tgtatatcct 3364741 caggacggat gccgaagatg acctctttgc cgatgtagcc tttttcacgc agcactttca 3364801 tttttccttc cgggacggtt aatgccgcag aaccgatttt gattaagcca tccgtgagct 3364861 ttcctttgaa aaaattcatc gccggtgatc cgataaaccc gccgacaaag acgttttcag 3364921 ggaattcata tacatccttc ggcgtcccga tctgctgaat tttcccatct ttcatgacta 3364981 caatccgtgt cgccattgtc agcgcttctg tctggtcatg cgtcacataa atcgttgtag 3365041 tctgcaatct ctggtggagc ttaatgattt ccgcccgcat ttgcaccctc agcttcgcgt 3365101 ccaggtttga caaaggctca tccatcagga acacctttgc atcccgcacg attgcccggc 3365161 ccagcgcaac ccgctgtctc tgtccgcctg acagcgcttt cggtttacgg tgcaaatatt 3365221 cctcaagccc gagaatttta gcggcttctt cgactctttt tttgatttca ggcttcggca 3365281 ttttccgaag cttgagcccg aacgcgatat tatcgtagac cgtcatatgc ggataaagcg 3365341 cgtagttctg aaataccatc gcgatatccc tgtcctttgg cgctacatca ttgacccgtt 3365401 ttccttcaat ataaaaatca cctttcgaaa tttcttcaag tcctgcgacc attcgcagcg 3365461 tcgttgattt cccgcagccg gacgggccga cgaatacgat aaattcctta tcggcaatat 3365521 gaaggttaaa gtcatcaacc gccggttcct tctgatcata aaatttataa atgtgctcca 3365581 tccgcaattc agccatctaa catccccctt tgttattgta aacgctttct tatattgagt 3365641 gtaacagcaa ttccctctcg ctaaaatggg cagcgttcat aaaatcaccc agccattttt 3365701 cgtgcatatt tccaatttat tctgaacttt cattttgcag gcagataaaa taggcaagaa 3365761 gcgcgccttt gtacgatttg atatctatcc ctgaccgctc aataaattta tcaatccgat 3365821 attgcaggct gttgcgatgc agatgcagct ttttcgctgt taatgtgacg tttgagttgt 3365881 tttcaataaa cagcttaatg gtcttcctta gctcagattc acttccaaat aaaagctcag 3365941 cttcttcaga gagcagtgtt tccagttttt ctttttctgt ttctaataat agaaaaggaa 3366001 agatcatctc aaaggtcaca ctctgcacct gaggcagccg tttttcagca aacaggaaat 3366061 acgcctgttc acgagcgtaa tgttttcgca gacactcatc cggctcgtaa aatcttccgg 3366121 cgtaaaaacg gacactgaag tagaaatcac tttcaagaac cttagcgagc gattccagtt 3366181 cgtccttctc cgccgccgct tcactttcct gctcgacaat cacacctctg tcctcatgga 3366241 tccacacaat cacaaaagac accggccaaa aatggcgaac cgcttccgta aaggacgtcc 3366301 tttctatttt gccgaataaa tgaaagtgaa caaatctcgt ccgtttcttt atatacgccg 3366361 gcaattcccc tctggaaaaa aggaacgaaa accacttgtt ttcctcaggt gatttcatag 3366421 acagttgatt gccctcatcc gcaggcgtca aaaatgactg cagcaccaat acttcttttt 3366481 cactgatctc tgttttcgga atggagatat atctctgatt gctctcatca aaaaaacata 3366541 gacagccttc ccttatgcaa agctcctcag acacaatcga accgggataa atagccagca 3366601 gcgatttcat agagtctcct ctcttatgta aggatctgta tattcagtat aaggcgaaac 3366661 acacatgttc tccactaaaa aagagtatat ccggtataga tagacgagaa actgaaaggg 3366721 aaacctcatt cgtttacata ttggcttcag cggaaataga agaagacatg caggaccaaa 3366781 ggagggtcat cttatgagtt tcgaaacgtt aaacaaaagt tttatcaacg gaaaatggac 3366841 tgggggagaa agcggacgta cggaggacat tttgaatccg tatgaccagt ctgtgatcac 3366901 aacagcatct ttggcaacgg gcaaacagct tgaggatgcg tttgacattg cacagaaagc 3366961 ccaaaaagag tgggccaaga gcacgacgga agaccgaaaa gccgtgctgc aaaaagcgcg 3367021 cggctattta cacgaaaacc gtgatgacat cattatgatg atcgcccgcg aaactggcgg 3367081 aacgatcatt aaatcaacaa tcgagctgga acaaacgatt gcgattttag atgaagccat 3367141 gacgtatact ggtgaattag gcggcgtcaa agaggtgcca tccgacattg aagggaaaac 3367201 caataagatt taccgccttc cgctaggtgt catttcatcg atttctccat ttaatttccc 3367261 aatgaatcta tccatgagat ccattgcgcc cgcaattgcg ctgggtaaca gcgttgttca 3367321 caagcctgat atccaaactg ctatttccgg cgggaccatc attgcgaaag cgtttgaaca 3367381 cgccggtctt cctgccggtg tccttaacgt catgctgacg gatgtaaagg aaatcgggga 3367441 cggcatgctc accaatccaa tcccgagatt aatcagcttt acagggtcaa cagcagtcgg 3367501 gcgccacatc ggtgaaatcg ccggtcgcgc cttcaaacga atggcacttg agctcggcgg 3367561 caacaatcca tttgccgttc tttcagatgc ggatgtcgat cgtgctgtgg atgccgcgat 3367621 tttcggaaaa tttattcacc agggacaaat ctgtatgatt atcaacagga tcatcgttca 3367681 tcaagatgta tacgatgagt ttgtagaaaa attcaccgcc cgtgtcaaac agcttccgta 3367741 cggcgatcaa accgatccga aaaccgttgt cggcccgctg atcaacgagc gccaaatcga 3367801 gaaagcgctg gagatcattg agcaggcaaa gacagacggc attgagcttg cggttgaagg 3367861 aaaacgcgtc ggaaacgtgc tgacgccgta cgtctttgtc ggtgcggaca acaacagcaa 3367921 aattgcccaa acggagctgt ttgccccaat cgcaaccatt attaaagctg gcagcgacca 3367981 ggaagcgatt gacatggcaa atgatactga atacggcctc agctctgcgg ttttcacttc 3368041 tgatttagaa aaaggcgaaa agttcgccct gcaaattgac agcggcatga cccatgtcaa 3368101 cgaccagtcc gtcaatgatt cgccgaatat tgcctttggc ggaaacaaag caagcggtgt 3368161 cggccgtttc ggcaatccgt gggtcgtcga ggaatttacc gtgacgaaat ggatttcgat 3368221 acagaagcaa taccgcaaat atccgttcta aatgaaaaaa tccctctgtt tcaagtacag 3368281 agggattttt ctttatttag atatatccac aaacccttcg ccaaacacat cgcgtacgtc 3368341 atgtacgatc acaaacgctt ttttgtcgca gcttctaatg atttttttca gcatagacag 3368401 ctcctgtttg ttaatgacga tatacaaaat ctcttttgac tggcccgtat aatttccctt 3368461 ccctgataaa atcgtcacgc cccgatccat caaggtattt acctgctctg caatctcact 3368521 cttattttct gaaatgaccg taatggcttt tttcgtattc aaaccttcaa taatgaagtc 3368581 catcactttg gtaccgatat acagcatcac gatcgtaaac atcatttttt ctgcaccaat 3368641 aataaaataa gagctaaata ctacgattaa atcaaaaaac aagagtgcat agctgatatt 3368701 ccagtctaaa tatttattag caattctggc cagaatcgcg gaaccggccg tcgtcccgcc 3368761 gacccggata atcatgccga tcccgactcc ggcaaataca cctgcgaaaa tcgtattaat 3368821 gatcaattca tcagacggaa tgctccaccc atgtgtcaga tgaagaaaaa gcgaatttgc 3368881 cgcaaccgca atgatcgtat aaaccgttgt ttttccatca agaaacttgt agccgattaa 3368941 aagcaaaaac gcatttaaga taaagttcgt gacaccagga gaccattgaa acagataata 3369001 caaaatcagc gtaatcccag tgactccgcc ttccccaaga tcattgggaa tcgcaaataa 3369061 attaaccgca agcgcgaaga aaaaagcgcc aatcacaagc ataagtacat ccagcattct 3369121 ctttttcatc acgaaaacac tccttttcat tgttctgttc tagcaaataa aaaaacccag 3369181 gagaacgctc tcgaaaaaga gcagaaactc ctgggctttt atcccaccgt gtcataacag 3369241 ccaagctgct atgtgttttc tctcggtcac agtccaattt gcattgcgga accctagaaa 3369301 accactgttt ttatcatatc cttttcactt tccaatatta gcattataag ggacggttcg 3369361 aattggttca aggggtattt gcggagtttt catcagataa gctggaaaaa aatacgattt 3369421 atctattaaa aaagaacaga tataaccgat aagaaaaaaa gcatatattt tacaagcgaa 3369481 tgtaactata aatgataata attataagaa attcataatt ttatattgac taagagaaat 3369541 aatataggca ttatagtaca tatgtttcgt acattttatt acataggagg aaatataatg 3369601 gcaggaaaac tagtaccctg taaagcttgc ggtcaagaaa ttgcaaaggg tgtaaaaaaa 3369661 tgtcctaact gcggtaagga tcaacgtaac ttttttatgc gacataaaat cattacgttt 3369721 attctcgcag ttgttgtcat cattattatc ggtaatatga ttggcggcgg aggcggctca 3369781 gaagccactt ccaaaacatc aagcagcagc aaagcagaaa ctgaaaaaac atacaatatc 3369841 ggtgataccg taaaaactga aaaaactgaa gtgacggtta cgaaggtaga ggacagagat 3369901 actgtcggta ctcaatatgt tgaaaagaaa gcatctgagg gaggtacaat tgtagctgtt 3369961 caatatacaa ttaaaaacgt atctaaaaag ccgattagct ctttttcaat tccaactgtt 3370021 aaattagttg atgctgatgg tacttcttat gattctgata ttgatgcttc tgtaaactat 3370081 gcaactgaga caaaagttga taactctaaa attttgagtg atctaaatcc taatattaaa 3370141 gtaacaggtg taaaagcatt tgaagttgac aaggaagctt atgcaaaagg cacttggaaa 3370201 ctaaaattca gtaatgatgt tattgtgaaa atcaaataac agctaacaag ggtgcctgtt 3370261 taggcaccct tgttctttaa aaaaggcctt ctcaattgag aaggcctcca ttcttattcc 3370321 gcactcttat acccattcac attagaagac tgccatctcc aggaatcagc acacatttcc 3370381 tcaaggccgc gtttcgcttc ccagcctagt tctcgcttgg ctttcgcagg atctgcaaag 3370441 catgtggcga tgtctcccgg acggcggtcc gcaaaacggt atggaacctc tttccctgac 3370501 actttttcaa aggctttgac catttccagc acgctgtagc ctgtgcctgt tccaaggttg 3370561 tatgcatcgg ctcctgtaga gttcaatact ttttccagcg ccttgacgtg gccttctgcg 3370621 agatcaacga cgtgaatata atcgcgtacg cctgtcccgt cttttgtcgg atagtcattt 3370681 ccgaatacgc ttaattgctc gagcttcccg actgctacct gtgccacata cggcataagg 3370741 ttatttggga ttccgttcgg gtcttcaccg atccgtccgc ttggatgcgc gccgaacggg 3370801 ttaaagtaac gaagcagcgc aacgctccac tcattgtcgg ctgtatgcaa atcacgcaat 3370861 atttgttcaa gcatgagctt cgtctgccca taaggatttg tcgcgcctaa tggaaagtct 3370921 tccgtaatcg gcgatgtttc cggaacgccg tatactgtcg cagatgaact gaatacgatt 3370981 ttcttgacgc cgtatttctc catggcctcg cataaaataa acgttcctgt caaattgtta 3371041 tgataatatt tgaggggaat cgccacagat tcgccgactg cttttaaccc tgcaaaatga 3371101 atcacagctt cgatttcatt ttcagcaaaa acggaatcta ccgcttcccg gtccaataaa 3371161 tccgcttcgt agaacgttaa atcttttcct gtaatctcct tgacacggtt cagcgcttca 3371221 gctgaactgt tggacagatt atcaagaaca acaatctcgt agccgctgtt caatagttca 3371281 acacatgtgt ggctgccaat gtaaccggca ccgccagtaa caagtattgc catgatgtaa 3371341 accctcctaa aaaatgacct gttttcatta tatagtgttt agaaccggtc cacatccatt 3371401 tttaagaagt ttaatcgttt attaatagtt ttttcatatt ttttagctta aacccttgcc 3371461 agcaattcga tagaggtttc agcaagaatg tgctctttca tttcttgata gagctcattc 3371521 aagtaaaagc ccggctgaag attcagctca gcatctaaag catagaccgt caatgtatac 3371581 gcatgatcct tgtcaggcgg tgtcggcccg caatactggt gaatcacctt tggatcgttg 3371641 cttcccgcaa gcggtgaagc aaagctgttt tgcccttgta tcatcaagtc ctgtctttcc 3371701 tcactcgcat gttcaggaag ctctccgatg taagccggaa tattagccgc tgtccagtga 3371761 atccagctga atccgcatac gggaatggcg tcatgatcga tgaaagtaag tgcgagcgtc 3371821 tttgctccgg acgggatgtc atcaaaatga attggaaagg atacaaatgg gtttccttct 3371881 ctcttatatt tttcatccgc gtattttgaa tacttgtcat gtaaatatgg atttgcttct 3371941 acgtatatgt tcatatgaat ccctctctct attttctcgt tctataggta tactaaacga 3372001 atcgatgtat aatcagtgat aaacaaatac gcatgtaaac gtaacaattt gttatggata 3372061 acttgcagtg aaggagatat ttcatggatt taaaatggct gcaaaccttt attgccgcag 3372121 cggaatcaga gagcttcagg gaggcggctg agcatctgta tctcacacag cctgccgttt 3372181 ctcagcatat gaggaaattg gaagatgaac tggacatgag gttgtttttg catagcggaa 3372241 gacgagtcgt actgactgac gaaggcaggc tctttttgcc ttatgccaaa gaaatgatcc 3372301 atgtttacca agctggaaag cagaaagtca gtcaatggaa acaggggtac agccgatcac 3372361 tcacgctggc cgtacacccc tacattgcgt cctatatctt gcctcgcttt ctgccagcct 3372421 atatccaaaa acatccgcat gtcgagcttt caactcatgt ggctggatct gacgctatta 3372481 aacaagcggt ggaacacaat gaagctgata ttggtttgtc gcggaaagac ccgaacacca 3372541 acactcttta ttatcagcat atatgcgaag gtacgctttg tctggcggct cctttccaag 3372601 aaagcagacc ggatgctgca tccgtcttaa cccgctatcg gctgctaacg catgatcatc 3372661 cgtcatatgg ggatgccttt ttagataaca tccgatcaca ttacccgtat cttcaaatga 3372721 tggctgtcgg gcagacggat acggctgtcc acatgatgaa agcgggaatg ggggcatctt 3372781 tcctccctac ctacattatc aaacaggaag aagccgaaaa aaagctgatg gctgtcagca 3372841 cgcctgcaca tctagaattg cctgcgtccc aaacgtttat gatgtggaaa agaaacagcg 3372901 aagacattca gcattttcac gccatgttac atgactttat gcagcgcgaa caagtataga 3372961 gctgaaaaat caatctgccg gttgacgttt ttctttccta ttttcgctat gcttaatgca 3373021 gaaaggattt gatgacatgg cgatgagccc ttatattttt attgtattga ttcttattat 3373081 tttatcgatg tatcgagaaa gaacggtaaa gcccgggaag ttgctgatca ttccactgtt 3373141 gctcttatgg ggcgtatctg catcgtttca gccggcgtat tttcattccg tattacatgt 3373201 ggcgatcagc ggcattttat tactgatcgg gctggcctgc gggtttggca ttgggaagat 3373261 ggtaaatgta cggattcacc cggaaaccgg aaaggtcact tcacgcggct cacttgggag 3373321 tgttatcctc attctagtga tactttcttt gcgcatggcc gcgagaacat ggctgcctga 3373381 gagcaacgag atgtttattg ccattattca ttctatgttc ttcgttcccc tcggcaccat 3373441 cacagcccgc aacatcatgc tttacaaagc atacagacga ctgaccgctg gcaaagtatc 3373501 cattcaataa ccgaaagaag gaccagcatg aacggacaaa ctccggctcg gcactactac 3373561 aagaagcttg tgccgagcct tattctcatt ttgaattgca tacaattttt atctcatcca 3373621 actaaggctg atcccatttt gttagcattt gtatttgcgg tatacttagc attcatttgg 3373681 atcattccct atgtggcatc cactgctgtt agtttgagca tattcatcgg actctggctc 3373741 ctgaccgatt tcttttgggc tgtttccggc caagagcagg gtgccgccta ttttttgatt 3373801 gtatttttaa tgatatatgc cgcctttaga ctcccttcac ggctatcctt gatcttcaca 3373861 gcatgtttaa ttggaggcaa catattactc ctatcctcac aagggggaag cttgaatacc 3373921 atcatcagca acatctcgat catgctcggt ctgtacgtcc tcttctcctc catgcgtttc 3373981 agacgagaag cgagaaggga ggctgaacgg aatcatgctg aattggcaaa aatgcatgtg 3374041 cagctggagc atgctcataa agaactccag aaagcgcatg cagagctgca ggaggcttct 3374101 gttctttcat taaggtacgc ggtccttgag gaacgtacaa gaattgcccg cgacattcat 3374161 gacagcatcg gtcacgagct gacttctgtg attgttcagc ttcaatccct tccctatatc 3374221 cttaaaagca gcaaggagga ttcagaaaaa gtcattcaaa atgtactgag tgtcgccagg 3374281 gagtgtcttc aagaagtgcg gtctgttgtt caccaaatgg gccgtagtga atcgatggtg 3374341 gggcttaccg ctttgcgggg gctcattcat caagtggagg aacggagcgg cttgcacgtt 3374401 tctttagata ctgccggact gtcagaagag tcttggcctc caaacgtgag cgaaacgatc 3374461 taccgcatct tgcaggaagc gctgaccaat atcattcgtc acgctgacgc ttctcatgcg 3374521 gcggccgtca tttctaatga caagtcccat ctctatgtca caatcaccga cgacggacaa 3374581 ttcaccggca gccttactta tggatttggc ctgacaggaa tgaaagagcg cgcagaaaaa 3374641 gcaggcggtt cccttacttt cagtgccgta cagccgagcg gcctgaaaat tgagctgtca 3374701 ttgccgctca tgacaacgaa taaggagcaa aaagatgaac aaagataaaa tacgcgtagc 3374761 gcttgccgat gatcagccgc ttgtgcgtga aggcttccgc tacgtcatca acgcacagac 3374821 ggatatgacg gtttctggcg aggccggcga cggtcacgat attatagcac tcgcaaaaca 3374881 aacaaaaccc gatgtcatcc tcatggatgt ccagatgccg cgttgctcag gcatcgaagc 3374941 ggcgaaagac attatgtccg cacttccaaa tacaaagata gtcattttaa ccacctttga 3375001 cacggaagaa tacgtatttg aaggcatccg tgcgggcgca gtcggctatc tgctgaagga 3375061 tacacttcct gaggagttga tagatgcgat tcgcgctgcg gccagaggcg aggcgatttt 3375121 ccgtacagtc acagctgcta aaatcatcag tgagacattt cgggcgaaac agcaaactca 3375181 tgccgaagaa ctggcagagc cgttcaccaa aagagagctt gaggttcttc agcaaatggc 3375241 ctacggactg agaaatgagg atattgctga aaagcttttc gtcagtgaaa gcactgtgaa 3375301 aacccacgtg caccgcatcc tgcaaaaatg caatgcccaa gaccggacac aggcagtcgt 3375361 ttttgccatt cgaaacggta ttgtgcaata gaaatctctc atcccgccat gctaaaataa 3375421 gacaaaggag atgattggaa atgaaagaag aaatcattga acggtttact acatatgtaa 3375481 aagtcgatac acagtccgat gaatccgttg acacttgtcc ttccacaccc ggccaattga 3375541 cattaggaaa catgctagtt gatgaattga agtccatcgg catgcaggat gcagccattg 3375601 atgaaaacgg ctatgtcatg gcaactcttc cctccaatac tgaaaaagac gtgccgacaa 3375661 tcggctttct cgctcacgtc gacaccgcta cagactttac cggcaaaaat gtgaatccgc 3375721 aaatcatcga aagctatgat ggaaaagaca tcgttcttaa cgaacagctg caggtcaccc 3375781 tgtcacctga tcaattccct gagctgtccg gctataaggg ccatacactc atcaccacag 3375841 acggcaccac ccttctcggc gcagacaata aggccggtat cgctgaaatc atgacagcca 3375901 tggattacct catcaaacac cctgaaatca agcacggcac aatcagagtc gcctttacgc 3375961 ctgatgaaga aatcggaaga gggccgcaca aatttgatgt gaaacggttc aatgcatcct 3376021 ttgcctacac ggttgacggc gggccgctcg gcgagcttga atatgaaagc ttcaatgccg 3376081 ctgccgcaaa aattacgatt aaaggcaaca acgtacatcc cggaacagct aaaggaaaaa 3376141 tgatcaactc tgcgaaaatc gcgatgaagc tgaacagcct gctgccggca gacgaagcgc 3376201 ctgaatatac ggaaggttat gaaggcttct accacctgct gtcgattcaa ggagacgtag 3376261 aggaaacaaa gctccactac attatcagag actttgacaa agagaatttc caaaacagaa 3376321 aagaaacaat gaagcgtgcc gttgaagaac ttcaaaacga atacgggcaa gaccggattc 3376381 tgctggatat gaacgaccaa tactacaaca tgagagagaa aattgaacct gtcatcgaaa 3376441 tcgtcaacat tgccaagcaa gcgatggaaa acctcggcat cgaaccgaag atttccccca 3376501 tccgcggcgg aaccgacgga tcacagctgt cctacatggg gcttccgacg ccaaacatct 3376561 ttacaggcgg ggaaaacttc cacggcaaat ttgaatacat ctcagttgac aacatggtca 3376621 aagccgtaaa tgtcatcgtt gagattgcaa agcagtttga agcgcaagca taacgccaaa 3376681 agccagtcca aaaaaggact ggcttttttg tgtgaaaatg aaacatttta aacacgtcct 3376741 ccgtaaaaca agtatcaaca aatgaggagg aaaaacaatg acaaaacatg caatcgctgc 3376801 caagagtctc ttgaaaaaat ggatcatttc caggccgctt aacatgaaaa agaaatccag 3376861 cccatttcaa aaaatcagaa aaatgttcaa acgcttcttc aaataaaaca tcaaatcccc 3376921 taaatacaat ccgtattcac ccgtaccgcc caaatgctcc gtaatttggg ttttttgtgt 3376981 tcaattccgc aaaatagggt ataaaccaaa caagcaagaa aacagcaccc aaaaacaggt 3377041 aattcgaatt acgtaaactt aggttaaaag ttatataaag gaatttattt tatcgtcgat 3377101 agtaactata gaaccaatca tcaacaagag caaacagcgt aattcaagac tattttcagg 3377161 tcatcaggta atactgtttt agagggacag tttcttgtta tttattgatt tagaattttt 3377221 tgaatacttt ttggcatttt atccgtacaa tagagagtac caaaactttt tttgggaggt 3377281 atgtaatatg atcctattta ttatcatcgc attatgcggc tatcttcttt tttctttcag 3377341 caaggacaat cgccgcaaac cgcaaaagac aagccctctg ccagcagccg cacctcatca 3377401 caacaaccta atcgaccttg acgccatccg ccaaaaacgc cggatgcatc tttcctaatt 3377461 ctatatttca aacgaaaagg ctgctgaatc acgcagcctt ttaaaattgt tttgatttag 3377521 agcctgaaac cttttcgcca cctatccgta atttcataca aggcaaaccc aaaggagact 3377581 tcagcaatga tcgagttatt tatgaaacaa aaaatgttct catttaaaga tgcatttcac 3377641 atttatgacc gggatgaaca agaaacattc aaggtggagg ggcgtttttt ctcgttagga 3377701 gactcattac aaatgacaga ctcatctggg aaaacgctcg tttccataga acaaaaacta 3377761 atgtctttat tgccgcgcta tgagatttca attggcggga aaacagtttg tgaggtaacg 3377821 aagaaagtaa cgttttccaa accgaaattt gtgatttccg ggcttaactg ggaaatagat 3377881 ggtgatttat ggagggatga attccaactg acggacgggg aaaatgtccg gatgtcagtg 3377941 agcaaaaagt ggctcagttg gggtgattcc tatcacttgc agattgcata cgaggaagat 3378001 gttctgattt gcactgccat cgctatcgtg cttgatatgg ttttatataa cgatgaagat 3378061 gaaagtattt tctaaaaagc attgacaatt gatccaaaag taataatatt aagataattg 3378121 aaatctgaat atgaagttgt accttatcaa gagaggtgga gggactggcc ctatgatacc 3378181 cggcaaccgc tgtttcaaac agaatggtgc taaatcctta agaacattgc gttcttgcag 3378241 atgaggcgga gatttgatcg ttcaagctct tccttacaca aaggaagagc tttttacatg 3378301 cttaatattt cagaaaagag gcgaataaca tggctcaaca aacgaatgtt gcaggacaaa 3378361 aaacagaaaa acaacgcaaa gcacctttcc gcgccgatca tgtcggcagc ttgcttcgtt 3378421 ccgttccggt aaaggaagcc cggcaaaaaa aagcggctgg tgagatgaca gcggaacagc 3378481 ttcgtgatat cgaaaatcaa gagatcaccc gcatcgtgga aaaacaaaaa gaaatcggtc 3378541 tcgatgtggt aacagacggg gaattccggc gttcctggtg gcattatgac ttcctggaag 3378601 ggcttgacgg tgtggaaccg ttcatcccgg ctgaggggat tcagttccat aacacaaaaa 3378661 cgaaagcgcg cagcatcaaa gtgacgggaa aactcgattt tacgagccac ccagcgctcg 3378721 gtgattatca atttttacat gagattgccg gtaacgcgac gccaaaattg accattccca 3378781 gtccaaatat gctgtttttt ggcgaaaagg cggataaagg gatttatgac gatcaagagg 3378841 aatactttca tgatatggcc caagcgtaca aaaaagcaat caaagccttc tatgatgctg 3378901 gctgccgtta tctccagctt gatgatacgt catggtctct cttctttgag gacaaaggca 3378961 gagaggttgt ccgggcgctc ggcggtgatc cagaaacatt gccagccata tttgccaaaa 3379021 caattaacga tgccgtcgca gaccggcctg acgatttaac gatcacaatg cacatttgcc 3379081 gcggcaactt ccgctcaacc tgggcggcat caggagggta cgacgctgta gcggaaacga 3379141 ttttggacgg cttaaacctt gacggccttt tcttggaata cgatgatgac cgctccggaa 3379201 actttgatcc gctccgtttt gtgaagcgca aggatctgca aattgtgctc ggcttgatca 3379261 catcgaaata cggcgagctt gaaaatcctg aggatgtgaa acgccgtatc aatgaagccg 3379321 cgcgttttgt cagcttggac cagctatgcc tgagcccgca gtgcggtttc gcctctacag 3379381 aagaaggcaa ccttctgaca gaggagcagc aatgggcaaa gctgcgccat gtcatcgaca 3379441 ttgccaacga tgtgtggaga taatctatca ttgacagaaa tagaaaatgt gtgaataata 3379501 gatactatca gaaaatttaa taaaaaggtt ttccttatca agagaggtgg agggactggc 3379561 cctgcgatac ccggcaaccg ctgtttaaca gaatggtgct aaatccttta gagcaatgat 3379621 tgctcttgaa gataaggttg agattgtcac gcaagctctt ccttatccaa aggaagagct 3379681 tttttatatt tgaatggaaa gaaggaatgg acaacatgtc acaacaaaca acacccgcag 3379741 aacaaaaatc acttcaaaga aaaaaaccgc cgtttcgcgc ggatcaagtc ggaagcctgc 3379801 taagatctga gcccgtcaaa aaagcgcggc tgcaaaaagc ggccggcgaa atgaccgctg 3379861 agcagcttcg ccaaattgaa aacgacgaaa tcatccgcat tgtggaaaaa cagaaggaaa 3379921 ccggcctgaa cgtcgtgaca gacggtgaat tccgcagagc atggtggcac tttgatttcc 3379981 tggaaaactt agatggcgtt gagccgttta ctcctgagca aggcattcaa ttccataacg 3380041 tacagacaaa agcacgcggc attaaagtca caggcgatat cgacttttca actcacccaa 3380101 tgcttgaaga ttactcattt ctccatagca ttgccggtga cgcgacgcca aagatgacga 3380161 ttccaagtcc gaatatgctg tttttccgcg gaaaactgga aaaggatgaa tacaaaaacg 3380221 attatcaact tttccagcac gatgtatcca aagcatataa aaaagcgatt caagcgtttt 3380281 atgacagagg ctgccgctac ctccagcttg atgatacagc gtgggccgtt ttcttatcag 3380341 aaaaaggctt aaaacaaatc gaagcgttcg gaacaacgcc tgacgagctt cgccagctgt 3380401 ttgcgaaatc cattaacgac gcgattgcag accgcccgga tgacttgacg gtaaccatgc 3380461 atatttgccg cggcaacttc cagtccactt ggacagcgga aggcggctat gacgcagcag 3380521 ccgaaaccat ttttgacggc ttgaatcttg acggactttt cttagagtat gatgattcac 3380581 gctcaggcgg atttgagccg ctccgttacg taaaacggtc tgatcttcag cttgttcttg 3380641 gcttagtgac atctaaattc ggtgagcttg aaaatccgga tgacgtgaaa cgccgtatcg 3380701 aagaagcgtc ccgttatgta agcttagacc agctttgcct cagccctcaa tgcggattcg 3380761 cttcaactga ggaaggcaac aagctgactg aagaacagca atgggcgaag ctccgccatg 3380821 tggttgagat cgctaatgat gtttggaaat aagcaaagaa aaaaacacac ttgattccct 3380881 agcggagcaa gtgtgttttt tatgtcattg tgcggtgtag cccccatcaa ggacgacagc 3380941 ctgcccagtg acgcccttcg ccttctcgct tgccaaaaac acggcataat ccgcaatttc 3381001 cttgacggaa agcagtcgct tttgcggcac aagcggaaaa atgacttgtt caagtacaga 3381061 gtcgtaaggg acatttctag ttttcgatag atcgctaagc tgattgcgta caagctgggt 3381121 atcgacataa cccggacaga gcgcattgac tgttatgccg tggggcgcgc cttccagcgc 3381181 ccctactttt gtgagtccaa tgacgccgtg cttggcgcta ttataagcgg atttccctgc 3381241 aaagcccact aatccattaa cagacgcaat attaatgatt ctgccaaact gctgtttttt 3381301 catgatcgga aaaacatgct tcattgcaat aaagggagcc gtcagcatga ccttgatcag 3381361 ctgttcaaag gtgtctgtcg gaaactcttc aatcggagcg acgtgctgaa taccggcatt 3381421 gttcaccaga atatccaagc ggccgtattg tttttggatg acgttcaccg tatcagcaac 3381481 ttgcgcttcc tttgtcacat catacggaat ggccgccgcg tcaaagcctt cttctgcaag 3381541 cttggaggct gctttttcac atgcttccgg acggaggtct gaaacgatga cgctggcacc 3381601 ttcccgggcg aattctcttg cgatttcgaa tccgattccg ccggcagccc ctgtcaccaa 3381661 agcgacttgt tttctcatgt caaacacctt cccattaaga attgagtaca gactggctta 3381721 cagcgaaatc agcttctgtt ttttcataaa cctcttcaat tgtgacacca tcctgaagct 3381781 ccgtcagtgt catgcggccg ttcacaaaat caaatacagc caaatccgta atcagcctgt 3381841 gtacgacttt ctggcctgtc agcggaaggg agcatgtttt tttcaccttt gattcaccat 3381901 gcttattgac gtgctccatg atgacaacga ttcgtttcgc cccgttgacg agatccatgg 3381961 cgccgcccat cccttttacc attttgcccg ggatcatcca attggccaaa tccccctgct 3382021 ccgaaacctc cattccgccg agaatagcta aatcgatatg cccgcctctt atcatcgcga 3382081 atgactcagc gctgtcaaaa taagaggcgc ctgtcacttc agtgatcgtt tcctttcccg 3382141 cattgatcaa atccgcgtct tccgttcctt ccagaggata ggggccaatt ccgagcaagc 3382201 cgttttccga ctgaagcatg acgtgaacgc catcgggtat ctcatttgcg acaagcgtcg 3382261 gcattccaat cccgagattc acattcatgc cgtccttgat ttcttgtaca gcccgtttga 3382321 ccattcgttt tctcgcttcc ttcacttggc ctcacccttt cccgatgctt gctgaactgt 3382381 tcgtttttca atccgttttt cttggctcgc gccaagcacg acatgctgta cgtaaattcc 3382441 cggcgtatgg atgtgatctg gatcgagctc tcctgcttcc acgatttctt ccgcctcggc 3382501 aatcgtgatc ttgcctgcca tggcggcaat gggattgaaa tttctcgccg ttttcctaaa 3382561 aatcaaattg cccatggtgt ccgctttcca cgctttgacg atcgccacat cgccggtaat 3382621 gcctcgctcc agcacataag tccggccgcc gaatgtttta tgttcttttc cctcggctat 3382681 ggaggtgccg acgcctgtcg ccgtataaaa tcccggtatg cctgcaccgc ctgcacgaat 3382741 tctctcagcg agcgttcctt ggggaacaag ctctacctca agctctccgc ttaaaaactg 3382801 ccgctcaaaa attttatttt caccgacata ggaagcgatc attttcttga tttgcttgtt 3382861 agccagaagc aaaccaagcc cccagtcatc gactccgcag ttattgctga caacggttaa 3382921 atcctttact ccctgatctc ttatagacaa aatgagctgt tcagggatgc cgcacagccc 3382981 aaaccctccc gcgatcagcg tatccccatc atgaatcagt ttcgcagctt ccttgcttga 3383041 tgacagcact tttcccatat tgatgcccct ttcgttttct tctacactag accagtcagg 3383101 ctgtaaatcg cgatcacagc aaatacggca gccgttttaa tgagcgtgat cgcaaaaata 3383161 tcgcgatagg attgccggtg ggtcaaaccc gtcacggcca gaagcgtgat aacggcgcca 3383221 ttatgcggca gtgtatccat cccgcctgat gccattgaaa tgacccgatg catcacctct 3383281 ggcggaatat tgtaagcctg aatcgcctgt aagtattgtt ctgacatcgc gcttaacgca 3383341 atgcccattc ctcccgaagc cgagccggtg attcccgcca gcgcagttgt cgtaacggcg 3383401 ccatttacaa gcggatcggt aaaagtatgt gaaattccgc tgctcagctt atgaaacccc 3383461 ggcagcgcgg cgataatgcc gccgaacccg tactcagcac ccgtattcat agatgccagc 3383521 aaggcgccgc caattccttc attcagccct tccttcaatt gggcaaacac acttctccaa 3383581 tcaaataata tcgttgtgat gatgccaatc actaaagcaa tctccaccga ccaaatagca 3383641 gccgctgaag aaatatcaag cctgccgaac tcctttaatc ctatggaaga aaaatcaaat 3383701 ccattcggat accactttgg caggtaaatg gtgaaatatt tattcactgc accgacgaga 3383761 ataagcggga caaaggcaag cgcgtgccga atcgggcttt tgtccggttc agccgcggac 3383821 tcaatcgatt caggagcagg agcattctgc gaatcaaaac cgccatagcc ttcgccagat 3383881 gcctgcgctt tcttccgcct tgattccaaa tagagcatcc cagctgccag cacaatcact 3383941 gcgcccatca aacccagcca aggggcggca taaatgtctg ttttgaaaaa cgacgtcggg 3384001 atgacatttt ggatttgcgg cgttcccgga agtgcgtcca tcgtaaacgt aaaagctcct 3384061 aaagcaatcg tacccgggat gaggcgtttt ggtatgtttg cttcttggaa catgtttttc 3384121 gcaaaaggat atacagcaaa tacgacaaca aacaggctga caccgctgta cgtcaagaca 3384181 gcacccatca gcacaatggc aagtatcgct ctttttgccc cgacaagccg gacaattgtt 3384241 ttcgcgattg atgccgcaag cccggccatt tcaacgacct ttccaaaaat agcaccgagc 3384301 aaaaacactg ggaaatacag cttaataaaa cccgccatct tctccataaa aattgatgaa 3384361 aaaaaaggaa gcacatggct tggatctgtc agcagcaccg cgaataacgc gcaaatcggc 3384421 gcaaacaata tgacagaaaa tccccgatac gccgtaaaca tcagcaaacc taacgccaat 3384481 agaatgatga tcagttccac acacacatcc cccgtttccg cgaactagaa agcgtttaca 3384541 aaaacctgtc cgcatcggct gtttccgtcc cctttccata tgtacgagaa gcgtgggcca 3384601 actattccga ttaaaaaagg aaagctcctt ttttcggagc tttcctctac cattcatttc 3384661 attcctatta ggatatcaac atcaaccgta atatcggctg atttcatctc tttcagcagg 3384721 ctgactcgat ctttcggcgc cgaccaggca agcggcgtca tcttgagaag ccagtggatc 3384781 gcctgctggt caagcgtttt aacatagcgc agcctgacag gacggctgtg tgctgcattt 3384841 gctgtaaaac gctcaactgc tgccgtattg gaatacgtgc gccttggtga atcagtatat 3384901 aaaaattgcc ttaattctat taaatagtcg cttcgcggca ctacttttat gagcatgcca 3384961 tcattcttca gcagtctatg aaactctgca taattggacg gcgaaaaaat agacagaaca 3385021 acatcaaatt ggcgatcatg aaaaggagca cgcgccacat cggcaaccgc ccacatcaga 3385081 tctttgaatg ccttagaagc ttttaagatc ccgtccttcg aaagatctat gccggttcct 3385141 atcgctgctt tccctgcata atcaaacccg caaagcgcat tcaaatgaga accctcaccg 3385201 caaccgctgt ccaagatggt gaatgcctca tgaccagatt tgggatgact gatgagctct 3385261 gcaatcgcat catggagcgg gtcaaaaaaa ccacattctc caatcagcct gctcctcgct 3385321 tcaaaaagct cggcaccgta actggttttg accggcttcg tcagaaagtt cacgtagccg 3385381 tgccgagata gatcaaatgt atgtcctcgt tctgtacaaa tcaagctttt ccctgatgcc 3385441 gcatccatag aagaatcgca gagcgggcat cgaaacatgc tgaaatcaac tgttcgcttc 3385501 atgataaaaa acaccccatt cattcatttt tagataaatg aaaaaggcat agacaaataa 3385561 acctaggcct atctcaaaaa ttggccaggt ctggcagttt gtctacacct gtcattatct 3385621 ataacgaatg aattggataa tcatgaaaaa aactcccttt ctgctgtatg ggtttccccg 3385681 tttccatcat acaacaaata tccaggagct ggaaccttat agtgaagaaa aatcagtact 3385741 gacatgctgg tatcccgcca acatcatatc agcatagcaa tccagcatgt ttttccttta 3385801 ttttctcatt ttagaatata aattttatta ttgtgaaaat agttaaaaag gttgattttc 3385861 aaaaagtgaa aggataaaat actgctatca tcttagaaaa agacattctt gtatatgatc 3385921 agtaatatgg tctgattgtt tctacctagt aaccgtaaaa aactagacta caagaaagtt 3385981 tgaataaatt tgaacgagtt gaaaaggaca agttcttttc tgtttgctct tatttttcac 3386041 actttctgca cttccagaat ttgtgaagga taagagcttt ttttgtttcc ataataaccc 3386101 tcataggagt tgctatcatg tactttttac taaaccttgt cggtctcatt gtgattatgg 3386161 cagttgtatt cctatgttct ccgcagaaaa agaaaatcaa gtggcgcccg atcattacgt 3386221 taattgttct ggaattgctg attacttggt ttatgctggg aacaaaagtc ggaagctggg 3386281 ccatcggtaa aatcggtgat ttcttcactt ggctgattgc ttgcgccagt gacggtatcg 3386341 cgtttgcctt tccgtcagtg atggcgaatg aaacagtaga ctttttcttt agtgcgcttc 3386401 ttccaattat ctttatcgtc acattctttg atattttaac gtatttcggc attttgcctt 3386461 ggctgattga taaaatcgga tgggtgattt caaaggcttc ccgcttgccg aaattagaaa 3386521 gctttttctc tattcaaatg atgttccttg gaaataccga agcacttgcg gtcatccgcc 3386581 agcagcttac ggttttaagc aacaaccgcc tgctcacatt cggtttaatg agcatgagca 3386641 gcatcagcgg ctccattatc ggatcttatc tttcaatggt gcctgcgaca tacgtgttta 3386701 cagccattcc tttgaactgc ttaaacgcgc tgattatcgc aaacctgctg aatcctgttc 3386761 acgtgccgga ggatgaagat atcatctata caccgcctaa agaagagaag aaagactttt 3386821 tctctacgat ttctaacagt atgcttgtcg gcatgaacat ggttatcgtt attttggcaa 3386881 tggtgatcgg atatgtcgca ttaacgtcag cagttaatgg cattcttggc gttttcgtac 3386941 atggcctgac catccagaca atttttgctt atctgttcag tccgttcgca ttcctgcttg 3387001 gactgccagt gcacgatgcg atgtatgttg ctcagctgat gggcatgaaa ttagcaacga 3387061 acgagtttgt tgcgatgctt gacttgaaaa acaatctcaa atcccttccg cctcacaccg 3387121 ttgcggtggc gacgacattc ctgacgtcct ttgcaaactt cagtactgtc ggcatgattt 3387181 acggcacgta caattcgatc cttgacggag aaaagtcaac ggtcatcggg agaaacgtgt 3387241 ggaaactgct cgtcagcgga attgcggtat ctttattaag tgctgcgatt gtcggcctgt 3387301 ttgtgtggta gaaacattga gccatatccc ttttcggata tggctctttt cattattgat 3387361 aaatagaggc tggcacctgc acatcccgga ttcccgctgc ataaggcccc aagtcatact 3387421 ggccgaagac gatggcgatc ccgtttgccg taaagtaaaa cattgtgtct ctgtttaggg 3387481 ttatatcctc tttctttaca tcagagaaaa acagcacatc gtgttttttg atatagctat 3387541 ataggtaatc tctcgttttg ctgacttttg ttttggtgtt cagaatctga tccagcgtca 3387601 cccgcttttg tgctttcaag tcatagttga aggactggac agacgttaga ccgtgggcgc 3387661 cccctgaata gatataattg agtgtttgaa tgctgagctt gcctgccgca ttgtatttga 3387721 cgctgaagga tgtttgatat tcccgtttta aagccctgct gttcgcctgc ttttttgttt 3387781 ttcaggtatt cctgatacga ttgttcatgt aggctttcag ctcttgattg attttctttt 3387841 caaacgcggc attcccgacg tgatgcactt gtggatacgt taactccttg atctttttgt 3387901 acgtatgggt gctgacagtc ggtgttttcg cttgaactgc ttttaaagat ggggccgcat 3387961 atgcaaatac agaaaaaagc aagactgcaa tgcccgcggc tttcagcatg ttattccatt 3388021 tcatacaatc tactcctttg atgtcgttgt ttatcattcc cttatttaag caatacacac 3388081 ttttatagac tgattaaatc gaaagaagtt tctaggtcta acagcatgat ttttccaata 3388141 aaaaaagaga cacaggatgt ctcttttttt actgtttgcg cccagaaatc gcttcatgaa 3388201 gggcttgtgc caaatctgta tttccgaaca tctctaatac cgcaatgaca gtctggtccg 3388261 gaatgtgctc tgcttcgtgt tttggcacga ccagatcgtc catggttttt ttcaagcttt 3388321 cattcagctt ttgctgcgga tacgctttgg cgtacagctc catcggatca agatcatggt 3388381 tcacgcacca ctgggcaaac accaaaatca tcatattttc atcgcgttcg taagcttcag 3388441 tgagctgttt ttcgttcatt tgtcatgctc cttatgaaaa gtatcttcct taaagataca 3388501 ggagccgatc aaattcgtct atcccaatgg cgatgagcag caaccgcatc gataaatgcc 3388561 ttgctgaaag cggtgtagtc aggttcatct ttagccgtta cgatgcctag cccctctgtt 3388621 gtcccgacag aggattgaag aaggtcaatt ccttcatttg ccgcaccgat cgccttgtag 3388681 tgattgtaag cttctctgat aaacgccatc gcttgtttgt tgtcttttaa ctccagtcct 3388741 cctgcggcat agacggcatc atacagaaca gaatcaaccg tcaggaacgt gccgctggcc 3388801 tcaagctgct gtccgctgcc gcttgtcata taccccagat tttgactgat gatatccact 3388861 gtgattcctt cttgctttaa ggcttccagt actgtttgca gctctttttc atgaaatccg 3388921 tttccggcga gtacagcgac ttttcttgtt gacgcggttt tcactgtacg ggcttggctt 3388981 aacgcaggcg aagtaagaat ttctttagat gctttacgct tcgcgggcgc cgccacgcct 3389041 actcctttgg cgatttcttc tgctaaatct gcatcgacat tgctgaagac atcaacgacc 3389101 tgccgctgta cgtctttgct tttgaccttc ccgacctcga agcagaaagc agaaatgatg 3389161 tgctgtttct ccacaggaga catgctgttc cagaaaagct tcgcctgtga gtaataatcg 3389221 ttgaagctgt cgcttcgctg gcggattttt ttgccctcga ctttttcctg atagtggacg 3389281 tagccgcctt cttcagctgt cgcaggcgac ggatcattgt tttgcagtga gtttttatga 3389341 taagcgacag gtcccttatt gatcgtcatc cggtgatagc cgtcgtattg gttgttatgg 3389401 aatggacaga ccggccggtt aatcggaatc tcatggaagt tcgggccgcc aagacggatg 3389461 agctgtgtat ccgtataaga gaaaagccgc ccctgcaata gcgggtcatt ggtaaaatcg 3389521 atgcccggca cgacatttcc cgggtggaat gcgacttgtt ctgtttccgc aaacacatta 3389581 tcctgattgc ggttcagcgt catttttcca atgatcttca ccggcacaag ctcttccggc 3389641 cacagcttag ttgggtcaag aatatcaaaa tcaaacttga attcatcttc ctcatcaatc 3389701 atctgcacgc cgagctcgta ttcaaccttg ccgccgtttt caattgtttc ccacaggtca 3389761 cggcggtgga aatctggatc tttcccggca attttttgcg cttcatccca tacgagagaa 3389821 tgcacgccga gcaccggctt ccagtgaaat ttcacgaaac gtgcctttcc ttgttcattg 3389881 acaaaacgga acgtgtgaac gccgaagcct tccatcattc tgtagctgcg cgggatgcct 3389941 ctgtcagaca tcgtccacat caccatgtgg gcagactcag ggttattggc gacaaaatcc 3390001 caaaatgtat cgtgagcagt cgcagcctga ggcatttcat tgtgtggctc aggcttaaac 3390061 gcgtgaacca aatccggaaa tttgattgcg tcctgaatga aaaacaccgg aatgttattt 3390121 cccacaaggt catagtttcc ttcttcagta taaaattttg tcgcaaagcc tctggcatcc 3390181 cgcaccgtgt ctgcggagcc tttagaaccc gcaaccgtag aaaaacggac aaataccggt 3390241 gtcttcaccg aagggtcctg aagaaatttg gcccgtgtgt attccgtcat tggttcgtaa 3390301 acctgaaaaa agccatgcac gccaaatccg cgcgcatgca caacgcgctc cggaatcctc 3390361 tcatggtcaa agtgcgtcat tttctcccgg aaatgaaaat cctccatcag cgtcgggccg 3390421 cgaaccccgg cttttaacga gtgctcatcc tctgacactc gcaagccttg gtttgtcgtc 3390481 attttcttcc cgctgttatc ggtcctgtac tgctcaagct gctcgtcctt tgagtgttca 3390541 tttacacgtt tgttttggtc atcactcatg tctgctcccc ctttttaaaa cgaaacattc 3390601 tacagcacat ttacccgtgg cgttcttcat ataaactgct aatccgctca ttaggatttt 3390661 tggtctacat ataaatatgc ggtcatacac atttgaaata agccttcttc acagaaagaa 3390721 aggatggaag cgcttaccaa aaaagctgtt gaatagggga ggtcatatca tgcttgccat 3390781 actcggtttt gtgatgatga ttgtctttat gtaccttatt atgtctaacc ggctttccgc 3390841 tcttattgct ttgattgtcg ttcctattgt gtttgccctg atcagcggat ttggcaaaga 3390901 tctcggcgag atgatgattc agggcgttac agacctcgcc cctaccggta tcatgctgtt 3390961 attcgccatc ctgtatttcg gcattatgat tgactcaggc ctgtttgatc ctctcattgc 3391021 caaaatctta tcgtttgtca aaggagatcc gttaaaaatc gccgtaggca cagcggttct 3391081 gaccatgacc atttcgctgg acggagatgg gacaacaacc tatatgatta ccattgcagc 3391141 gatgctgcct ctctacaaac ggctcggcat gaaccgtttg gtgttagcgg gaatagcgat 3391201 gcttggttcg ggggttatga atattatccc gtggggcggg ccgactgcga gggttttggc 3391261 ttccttaaaa ttggacacgt cagaggtctt tacaccgctg attcccgcta tgatcgccgg 3391321 cattctctgg gtgatcgccg ttgcttatat cctcggaaag aaagagcgga agcggctcgg 3391381 cgtcatttcg attgatcacg caccgtcttc cgacccggag gccgcaccgc tcaagcgtcc 3391441 cgctcttcaa tggtttaacc tgctgctgac tgtcgctctg atggccgcac tgatcaccag 3391501 cctgctgccg ctccctgttc tttttatgac tgcgttcgcc gttgccttga tggttaacta 3391561 tccaaatgtc aaagagcagc agaaacgaat ctcggcgcat gcgggtaatg cgttaaacgt 3391621 tgtctcaatg gtgtttgctg cgggcatatt cacaggcatt ctctccggca caaaaatggt 3391681 ggatgccatg gcgcattctc tcgtttcact catccctgat gccatgggcc cgcacctgcc 3391741 gttgatcact gcgatcgtca gcatgccctt cacctttttc atgtcgaatg acgcctttta 3391801 cttcggtgtc cttcccatca tcgccgaagc cgcttccgct tacggaatag acgccgctga 3391861 aatcgggagg gcctccttgc tggggcagcc tgtgcatctg ctcagcccgc ttgtgccttc 3391921 cacctatcta ttggtaggaa tggcaggcgt cagctttggc gaccatcaaa aattcactat 3391981 taaatgggcc gtgggaacaa cgattgtgat gaccattgcg gcgcttttga ttgggattat 3392041 ttctttctaa atgtatgagc ttgatcgtag cattgagtga gtacgtgatt tacagagggg 3392101 agaagatcaa ataggatatt atgagtgaat agaagattca tgccaacaac ttctcattac 3392161 aatcataaga gcctgctata ttgcagcagg ctctttcaca tttggcatta tttttttgta 3392221 tagcgcaccc agtcataatg agcgtatagc ggatttacac cattgtagga gccaagccat 3392281 tcatcgacac ccgtgccatt ccacaagttc atcatgatct ttccaggtgt tgtcggaatt 3392341 tggtttgttg cagtatgttt taattgcccg tcgacatacc atttaataga gtttggctgc 3392401 caatcgaatg catacgtatg ataggcattg gctgcatcaa acccgagatc aacaatcttc 3392461 tcatggtttc ctgcaccatt tgtataatag ttaaattgaa ccttcgttgt gtcttttcct 3392521 aaaaattcga tatcaatctc atcccaagga gttccatctg ttggacctgt gtaagtgaag 3392581 aacgatgaaa cgatccctgt gtttttagct ggtttcattc tgacttcata aagtccatag 3392641 ccatatgttt gaacagaacg gttttccccg cagtcaaact tgttataagc tgggcttgtt 3392701 agcgctaaac gcatttcacc caatgacgtc attgatacgt tattagcccg ccacgtgcag 3392761 ttgaacatat ttccattcga ataaccatct gctttttgcc aaaaaccgga gttatagccg 3392821 ttaaaagggt caaaaaacga tccacctgtt tgagctgagg cagtagcagt gactgcaaac 3392881 aaactcataa acaatccagt gacaagaagc agcaacactc gtttcagata aggcatattg 3392941 gcattcccct ttcattgaaa gcgttttcta tgttgatctt acatgattct tttaaaaggg 3393001 aacatcggtc aaaataatga taatatcgaa tcttactaac ttgaatcctg taactatcat 3393061 catcttccct ctgaaaaaaa taaaaaccta aattaccatc agcacagaca gagatgatcc 3393121 gcactcattg caatttaggt tttgcctgct ttatcagtaa caatcctacc attttcatat 3393181 gtgaatgtaa gaaaaagtga acacaaggaa acacaaatgt cagcgctctc attatgcttg 3393241 tttaactacc ctttctatgt gaatggttaa atacagcagc tcgtcacttg tgagcttgtg 3393301 ctcatactcc cgctcaatgt aggtttggat tttcttcgtg cattcatacg cgcgatgata 3393361 cttttctttc actgtatcca gcaaaaaatc gtcctggctt tccatgtgag tgccgttaaa 3393421 tagacgctgc gcgaaaaact ttaagtgggt gacgaaccga taatagtgaa gcgattcttc 3393481 gttgaattca atcttaaaat ggtattttac aatactcaaa atctcttgca tgacttttgt 3393541 aatgttgata atattgggca tctcttcatt cagctcggca tttacaatat gcagagcaat 3393601 aaagcctgct tcatcctctg gcagagacac accagtcttg ttttttacca taaccaacgc 3393661 ttctttgccg atcgcaaatt cgtctttgta gagccgtttt gtttcccaca gcaaggcgtt 3393721 tttgatatca agccctttct ggttgcgctg gatggcaaag ttaatatggt cggtcagcga 3393781 cacatagatg ctgtcgttga gctttttgcc gagctgtaat tttgcgtagc tgataatctc 3393841 ttcggatact tccatacact cgatcggtat atcatacaaa agggttttga acttttctga 3393901 tacatccttg ttatcgagcg tgaacacttt ctcaatgcgg gcttcatcga catcatcgcc 3393961 ggactttttc tgaaacgcga gccccctgcc catgacgacc aattctttcc cctgttcatt 3394021 gaccacgctg atcacattat tgttgatcac cttcgcaatt ttcatggcat gtccctccaa 3394081 atctactaag aacagactat atcttgattg tacattcttt ttgtactagg tcaatatcat 3394141 cagggaaaga cggaagctgg tcagtacaat tcactccgta cctgctgccc gggctgtttt 3394201 tgaagcagcg cctccagatg gcgttcaaat gatgccttgt cagctttctg ctttttgaca 3394261 atgctgttca tgattttaat gctttcagca ctgtattgtg tatattgttt tttcagctga 3394321 tccagctgct gtcttgtctt cttcgcgttt ttcggtgtga cttggttgat gagtttgatc 3394381 atactgtctg cggtctcaaa aaaaccggct ctattttctg tcagctgctg aatttcgatg 3394441 cggctcatat cttgattacg cgttttttga agcaaggcaa ccgcctcgct gttttgtttt 3394501 ttgagcgatt tgttctcaag cttaatcgat tcgagattct ccttcgcaat gtctgcttct 3394561 tcttcagtca tgctgattcg cacgaagtat tctggattgc cgattccata atcaaatgct 3394621 tcgctcactt gtatcatgga actgaacaca atggccagct gcctgtcgct tgcgagggct 3394681 tggaaatcct gctttttctt actgctcatc ggtttggctg cggtttgttt tactgtcttt 3394741 tgatcacagt ctgcgaacat ctgagcctca ccttcacttt cgcatgcgct catcacaaga 3394801 actgtgacca gcaggcttat acacaagcct attcgcctca tgctctgtct cctctctgct 3394861 gaatcccttc tggaaaatac cataaaatat agttaaatgg taccagatgc acctaacccc 3394921 agcaataaat caaaagtatg atttgaagcg aaaaaacata aatattttgt aaaaattgac 3394981 gtgcattcca ttcttttcag gcccatttct cgtacaatag aagtatcgtt accggagagg 3395041 ggctctgatg atgaaacgtt ttacgaaaca agaaaacagc tgggtgttat atgactgggc 3395101 aaattcagct tactcaattg tcgtgaccac cgcggtattt ccgttatttt ataaatcagc 3395161 agctgcggaa agcggtgtca gcgccgctca atcgactgcc tatctgggct ataccattgc 3395221 gatttcaacg tttattcttg cgatgctcgg ccctatttta ggcacaatcg ccgactatga 3395281 agggtgcaag aaaaagttct tcggtttctt tgtgtcagcc ggtgtcgcca gcaccgcgat 3395341 gctcgccttt atccctagtg aacattggct gctattgttg ctgttttata cggtatcggc 3395401 tatcggtttt tccggcgcca atgtgtttta tgatgccttt ctcgtggacg tcacgcctga 3395461 gaagcggatg aatctcgtct cggcacgggg ttttggctta ggatacattg gaagcacgat 3395521 tccatttatc atcagtattg ctgtcatcct gctcgcacaa gcagagacta ttccagtgtc 3395581 tgtatcggcc gcaagccagc tgtccttctt cataacggct gcctggtggg ggctgttcac 3395641 catcccaatg attaaacatg tccatcaacg ctattacatc aaaaaagaac ctcatattgt 3395701 catcaacagc tttaagcggc tcggccaaac gatgaaacgg atcaggcaat accgggcact 3395761 tttcctcttc ttgctcgctt atttctttta tatcgacgga gtcggcacga ttattacgat 3395821 gtcgacatcc tatggatcag atttagggat cggctcctca agccttctga tcatcctatt 3395881 tgtcacccag gtagtcgccg cgccgttttc gattatatac ggaaaactgg cagaacgctt 3395941 cacggggaag accatgctgt acgtcgggat cgtcatttat atgatcgtct gcgtgtatgc 3396001 ctattttatg gagacaacgc ttgatttctg gatactggct atgcttgtcg ccacctcgca 3396061 aggcggtatt caagccctaa gccgttccta tttcgccaag cttgtgccaa agcgccacgc 3396121 caatgaattc tttggcttct acaacatttt tggaaaattc gcctcaatta tggggccgct 3396181 gctcattgcc gttaccgccc agctgaccgg taaatcctcg actgcggtgt tcagcctgat 3396241 cattttgttt gtgattggta ttgtgattct tgcctttgtt cccgaggaaa ccagcacaga 3396301 tgtcagccag cagcaaaatg acctgcccct ttaactggga gcaggtcatt catcatttat 3396361 tcgctttatt caccttcagc tgtttccctt tgacggttgt gttcttcatc actttgagaa 3396421 catgagggcc tttaccattt aaaatctcaa cgtatgaggc gttatccatg atcgtgatga 3396481 tgccgatgtc gtcagctgac acaccgtcaa ttttggcaat cgttcctaca aaatcaacgg 3396541 ctctgatttt ctttttcttt ccgccgttaa aatacagctt cataatgtct ttattcagct 3396601 cttcgctttt gtcctttttg ctttccggac ggtcattcag tttagctaga aattctggtt 3396661 tcttccttgc cacttcctct tgagaaggtg cttctatttt ttggatttca aatccgatat 3396721 attcttcaat gtcggctaaa aaccgttttt cgaaggccgt gacaaacgaa atggcctttc 3396781 ctttgttccc tgcgcgtccc gttcggcccg tgcggtggac atagctttct ttttcaagcg 3396841 gcagatcata gttgatgaca agggagatat tttcaatatc aatcccgcgc gcggcgacat 3396901 ccgtcgccac taagtaacgg tactcgccac gtttaaattc attcatgacg tcgaatcggt 3396961 cttcctgaat cattccgccg tgaattttat cgcatggata tcccaagtca tccaattcat 3397021 cggtcagctg attgacgtgc tccttcgttc ggcagaaaat gatgcagctg tcgggattct 3397081 ccgtcatcag cacatctttc agcaatgaaa acttattctc ttctcttact tgaatcaccg 3397141 catgttcaat atttcttgtg gttaggccgg ccgctttgac ctcgatatgc tcggggtttt 3397201 gcatatattg acggctcagc ttctcgatat cctgcggaag cgtcgctgaa aacagcatcg 3397261 tcgtacgctc agtcggcaga tgcttgataa tcgcctccac ctgctcaatg aagcccatat 3397321 tcagcatctc atccgcttca tcaatgacca aataagagag acgatccaac ggcagcgtgc 3397381 ctttttcgat atgatccaga acacgtcccg gcgtgccgac aacaatgtgg cttttttgct 3397441 taagctcagc tttttgttta tcaaaggagg attttccaaa tacggctgtc gctttgatcc 3397501 gtttaaatcg tccgatgttc gtgatatctt cctttacttg caccgcaagc tcacgggtcg 3397561 gtgttaaaat aagcgcctgc ggcttgtttt catcccaatt cgccagctca cagagaggaa 3397621 tcccgaacga agccgttttc ccgcttcctg tctgtgattt gacgacaaga tcctttcgtt 3397681 caagggcagc ggggatcaca ctctgctgca ccttggtcgg ttctgtatat cccagtcctt 3397741 ccaatgctcg taaaatgtca tgactgattt gatagttttt aaaatgactc atgtataaac 3397801 tcctgtctct tgcagatgtt ctcattatac tctaattgac caaggcatat gtgttttgtc 3397861 gaaaaatgat gtattaaaag ccagcgattc cctggcgttt tagctcctga acagccaatc 3397921 gcgccagtgc gtcggccccc gcgcgattcg ggtgcagcgt atctccatcc atataaagcc 3397981 cgagtgttct ttccggaccg atcgatgtaa agtatgccga gctgaggaca tttaagtcaa 3398041 tgagatatgt tttttcctct tcggccaaag ctaaaataga ggccctgtac catctgttta 3398101 cagacgaatg gatgccttca gaagtaaaat cggttgcccg gccctgaggc gttgatagga 3398161 tgacgtccgc tcctttcgct tttacctgac gaatcatatc acgcatcacc tctttaaact 3398221 ccgcttcaga ttctttatgc ttcggatttg tgtcattaat gccaagctgc aacataaaat 3398281 aatctccggg tttaatatac ttcagaatcg cctcaagctg tccatcattt ctgaaccctc 3398341 tcgcgatctg cccgccagac gccatgtttc tcacttgaaa ggtgtgttta tcgatatagt 3398401 gaggcagcat ctgcccccag cccgcctgct tgctgctgtt gagcggataa taattgcaca 3398461 ccgtcgagtc gccgccgaca taaatggttc gattcgttac cggctgatca gacaatttct 3398521 ttattttcaa ggcgctgagc gtaaaagcgg tgcctgcctt tccctctgtc accagcagat 3398581 tcagctgccc gtcggtgacg ggaatttgga acgtatcctc cgcgccatcc cctgtcatat 3398641 tgatgacctg aaacacgccc tccgctgcca cactggccct tgccgtattg ccaagcgtca 3398701 ccttcacctc ataaaggcca ttcgggagat caacattaaa cgtgttattg cttttcgtcc 3398761 catacgctaa aaactgaacc gcatcactct tcacaccagc cccggatgcc gccacatccc 3398821 tcatattctc cggtgtttga aaaccgtagc cctttgaccg gtcataccga tcagacgccc 3398881 tgacaccaat ataaccaggc tccatcgaac cgcttccaaa gtcaaactga tacaccttcg 3398941 gctccgccgc cttcacattc tcaatcccgc caaaacacag catcagcatc atcacaaaaa 3399001 ccgctgccat ccattttttc atcaagactc cccctctatg aaaacgaata cattaatgca 3399061 tactcggtga ttgtttcttt atgatgactg aattaagaaa aaaattgcgt tgaggaataa 3399121 aaatgagggg agagtctcaa gaaggggaaa atcagtgtga cttcttgtca cacttgatca 3399181 catcccaacc tccgcaatag aagcttattt ggttttcttc gtcatacaca taataacgga 3399241 gtctttccca ttgatcgtca gtcggtacaa tctccaatgc aaccgaatcg atggattcaa 3399301 ggtcatccag ctttgatgca ctaatgtttt caaaccgcaa ttgaatgtca caggtttgag 3399361 cagatcgttt tcattcaaac acaggaatat gaatataacg atcatcttct ttcatataga 3399421 aagaaaactc gtttaatgta aatggacctg tatcctcatc agaaagatgc tgtttcaatt 3399481 tctcgtattg tgtgatattc aaatgaattc cctctattta tatgattcac cgccaatcat 3399541 ataaatgtcc acagcatcgt attcaaacca tatgatccgt tcgcctgagt ccgttaggca 3399601 ttggagcttc ccttctgaaa aatagctttt atccggttga ggatcagtga tcagaaaaac 3399661 atcatcattg atggaagcta gcagaaagag aaaatctgca atatcccggt ctgcttcctg 3399721 taatatggat tggaaatgga attccctttt ggccagcttc gtcaccttgt aagcatgacc 3399781 ttcaaaatac tcggacaggt cttctataaa tgaaccagtc gttattacct gtatcatgat 3399841 tcgatcgtag gcaagccctg cccaaaaacg ataaaacgac tctgcatctt caagttcgca 3399901 tgccataacg gtttggtcag gcttaagctc gatcatgtcc aaattgccaa tactgcttat 3399961 agaggttatt tccataaaat cttcccctta tcagttggat agcgcaacgc aaatctcttg 3400021 tctgacttgt tcatacaaga gaatgtgatg atacagatcc ttatcgtttt tgatcatatc 3400081 cggaagtatg tcaggataca gctcaaaaaa gcttttctcc aacgaacgcc gctgatgccg 3400141 gggtatcctt ttattcgcca gcacataatc caaactgcca gcaacaagca taaaaaactc 3400201 atagatttcc gcttcaaagc cgtacaattc atcagggtac tgcttttctt caagctctcg 3400261 ctgtcttttt ctcagttttt gaagcacgtt gatcctctcc cttccgcaat aatctcattt 3400321 atttcgaaac agaataggcg gatcattatc tatcgcctcc aacagctctt caccaaacac 3400381 agtgattgca catttccacg ggtctcccaa aagtccccag gagaagtcct gatgaaaaaa 3400441 gaaataatag tctccatttg gaaatacggg aacaggccat tcgccaaatt catccttagg 3400501 cattgcctga tgaggactaa aggtatatcc gtcatgctgc caatctagtg cgtacattac 3400561 atcgttcttt ccagtaccta attgaaatgc ttttaaaata gaagtctcta aatcacttag 3400621 cactccgctc acatcattat gaccagcttt actgctcatc gcgcttgaga tatcaaacac 3400681 tcgatatgga tcaggcggga tgatgtgatg acatctgctt ccgggcttcc attttatgat 3400741 cttgttcact tctgaccaga tgcggtcttg ttttgtctga cttaaagcgc gccaattcat 3400801 cataatctca tccctacacc ttattggata tcctgcttat aaacaccaga agaggccact 3400861 gcgtaaacag cgtaacttgt cagtttcagc tgttgaacat ctaggccttc accgttcgaa 3400921 tcacagcatg ttatctcttc catctcttga ctcacatcgg cagaaatcaa ataaagagac 3400981 gacttaaggt ctgcactgta acaattgaac gtcccaacca aaaaaccttc ttcggatatc 3401041 gcgagctgat caaatgcttc tgagtccggc tctttatccg acagaatcca cacccgtctc 3401101 acgaccgttt catcaaatgc ggcaatgact gcatctccgt aatacagcat ataaatcaag 3401161 ccgttttttt ctgcaagtcc ataacaatca tctacagcag gcgcatccat ttcttcaagc 3401221 tttctatcaa tgtgtatttc cttctgctga ccatctaacg taaaacacca cacactatgg 3401281 ccgttgggat tctcatcatg ataaatccct tcatcacata aaccgaccca aagctgttgt 3401341 ttctaatcca aaagacagca ggaaacccct gaaggcaagt gaaaaacact tttcaccctt 3401401 ccctcttctg aaaaaacctt taccttcggc tcgtacgatt cgtaataaac gaagacatag 3401461 ccatctgcac attgttgaaa gagcagaata tcactgtatg aaatctgctc tttcactcta 3401521 aaatcccgaa catcaccgga aggatcatag attgtaatgg tgataccacc tttcaaccct 3401581 tttccaatgt agacacgccc ctgtggatca gcatggaaaa aacaatcttg ggtgttctcg 3401641 ttgatgattt tattcaattt taattttttc attggttatg ctcctaggtt cgaaatgaaa 3401701 tgataagaat aaaccattta ttagctatta gtaacggaca acctagtttc attaatcgtt 3401761 ttgggataaa tctactttcc aattcagcct taaatcattt agtgtttaat tggtatgcat 3401821 aaaacgattg atcatcaaag cgaactgttt cagcttctat agcaatcagc attctgttca 3401881 tgtcaataag aaagttagca tttgattgat actccggaat tatagaattt gatagattcc 3401941 cgattccttc tggatgataa ctcatctcaa atacttgcca attgtattct tccggatcta 3402001 ttttttccaa tctcatgtcg ccaacatctg cactataata agcggatgcc acattttgaa 3402061 atgaaatttt atgcgtatat tcaccttcat cttcaaaaac cttaatatca agtgagagtt 3402121 cttttttaaa cacattaaaa tctaaatgaa ggacactgca ccccttatct atataatcaa 3402181 cccattcatt aatcgtttga tacattgtca tcccctgcct ctttttaaac aataacgcct 3402241 tgccaccaag cagaaaacaa attactccgt atattgtttg atccaatcat ttaaatcatc 3402301 tgttgaatgc aaataagttt ctgatgaatc tttcaaatca atcccactta gaaggattaa 3402361 catatcccag actctatcgt cttctacttc ggggtcatcc gcataaacat aagttccagc 3402421 ccaatccgac acttcttctc ttgttgtttg tccatttaag acacttttga ttttatttat 3402481 gcattctatt agatttgtct cgctcaattt gatcaccacg tattcaagta ctaaatgatt 3402541 ttttattagt atgcaaagca ccgtactgat atttagatat tgaagctttt tccgtaaaag 3402601 atatgttcca aaaggtttcc aatctaccaa taaacaagct cacatccgta ttccgtgtgc 3402661 aatatacata aaccaaactg gcacttaggc tcaaccaaaa taaaactatg attgagaatc 3402721 ccttcatcga actcaataca ctccaataag cagtcaaggt gctcgagaca ttttccaaaa 3402781 gaacaaacta acgcaccaat ttcgctgctg tattgatgaa acagcagaac gtcccggtca 3402841 tcgtaagcaa catatgactg agatattttc cagatcagct gtttcgcttc cgttttttcg 3402901 agggcatcaa cctcacgggt gttggctggt attgaatttg ataaaaccag ctcaagcaat 3402961 tgcctgcttt gcgccagatc agcaaaacga taagtgaagc ctctttctgc acaagggact 3403021 agtttttctt tgatttcgct catcaataaa cgtcttttat tctcggcgag tttttcgatc 3403081 aatctttttt gcatgagccg cattccctcc gctgtcaatt tctcaacttc ttttaaattg 3403141 attcatcatt ctcttgtttt cgttgtcgtt catgtttaga tttgttctaa aaaagcttgt 3403201 atcgcttatc gatacaagct ttatcttcaa ctgcttaaaa ctcacccagt gggcttttca 3403261 caaaacgctg ggaacctttt tggcaaatcc tcttcatccc aatcaattct atatttttag 3403321 attcttttgt catacaaata agagaggatg gtaacatctc ttatttaatg ttccatcaat 3403381 aaatgcccca tttttatcca atgcagaaat tatttataat taaggaagtt tagaaggatt 3403441 ttttgtattt tcaagattta attttaaagc ggtcacaaaa gactctagct tttcttcatt 3403501 acaattaatt tcgaacaagt tggagttcga cttactttct ttataatcat caaatataat 3403561 tttaatctta attctgtaat ttccgttttc ttgatcaata ctaagaaata agaatggttc 3403621 aatagtctct aaactgatac tgtcttgatt tccttttatc atagtttcga tcccagatat 3403681 caacacctta tattcacttt ctaataaaac agcagaaaaa tcgcgaacga cggctttctt 3403741 attttccaac aattcaaata cagataaaat aaatggatca tcgtccaact cttgatacct 3403801 tctcggtgtt aattcaagtt ctatacaatc atcttttatt ttggccatat ttcctcctca 3403861 tttaaagttt aagtgagggt agttgtcatc cccccctcgc ttaaccttat taacgccttc 3403921 tcttagattt atttcctttt ccgtgtgtat ggaatacgtg tttagaaccc ttagctcttg 3403981 aacttccata agctgtgatt actttacccc ttttatttaa aacaactgta gctttttttc 3404041 caacatattt cgttgcccca ttaggttgtt ttattacttt tttagggctt cgcacagcat 3404101 tcagtttggc ccttaaattg actccacggc ctccatttct tcctatagat tgattaagtc 3404161 catgtcttgt atgacctgtg attttaactg ccttcttcgt aaacttatag gcgcgactag 3404221 cacccttaaa tatcttccca ggaccaaaat tagaagcagc tgcccaagca gcacctttcc 3404281 atcctttacc tgatttatat gccttatatc catcataggc tgcaaatccg gcatttacca 3404341 caagccatac ccaatgcccg tccggatcaa cattcatcac tgggttatta tttccataag 3404401 catacccatt ctgatccaat gaatctccgt cgctgcccgg gtctgggtcg agcgatagga 3404461 acacgccgtt tcttggctcg tagtagcggg ccatgagata gtacaggccg gtttcttcgt 3404521 cgtattggta gcctgcgtag cggtagcgat tgtcttttac ttcgtcgctt gcttcggttt 3404581 ttgttggatt tccccatgcg tcgtattgat acttggcaac ggtttttcca gtgctgtctg 3404641 agatcgcgat gatgtcgccg tgagcgttgt agtgatagaa atatttctta ccattttctg 3404701 tgtaggataa cagctggccg ctgtctccgt acgtgtatga ttttgtgacg ttgttgtccg 3404761 cgtctgtttc atacaagacg ttcaagctgt ctccgtcgta gaagtagttc gtgacttttc 3404821 cgttgacggt tttttggatt ctgtttcctt tttcgtcata cttatatgtt gcgaatggct 3404881 tgtcttcgcc ttttttggta acggcggtca ggttatcttc tgcatcccac gtatatgtga 3404941 atttgccgtc ggatgtgcgg ttgccgtttt tatcgtaaga gatgctttca tcattgactt 3405001 ttgtcagctg gttcatgatg ttgaaggaag cgttcaccgt tttgcttgag ccgtctttta 3405061 tagttgtaac ggttttccgg tttccgaatc catcatatgt gtattcaata acagtaccgt 3405121 cttcatgggt ttctttgaca agctgattca gcttcccata ctcatattgc accttgccgc 3405181 ttgctgagct gtttatcgtt gtgcggttgc cgttggcatc atattcatag ctttccgtca 3405241 gaatgtctcc gccgtttttg tcaccgatat gcagcgagct tacaaggttt ctttcgtcat 3405301 atgaaaaact tgttccgccg ccgttgcccg taataaaggt ttggacgttt ccattttcat 3405361 cataatcaaa tgaatatgag gatgtactgt ctttcatctc aatcatttga tccagcttgt 3405421 tatacgtaaa ttgattcgtt cctttttggt ccccatgaat ccacgagaag gttttcagct 3405481 tatcggagtc actaggatat gtccaagttt ggctgccgcc gcggtctgtc agttcggtta 3405541 aacggttttt gttgtcaaat gtccgtttct ttgtggtgtt ctgctcttta ttgacgaccg 3405601 acgtttcatt tccatttttg tcatacgtga aaatgtactt ttctgtaccg ttatacgact 3405661 ttgatttcac ccggtctgtt ccatcataag aaagagacac ttcgttgcca tttggtgaaa 3405721 tggttttggt caggttgctg ttggcatcat attcgcttgc taacacattg ccgagagggt 3405781 cagttgtttt gacaagcttg cccatgacat catattcgaa tttataggtt tgatctgctc 3405841 ctgcccggat ggttttgctt acctcattgc cttccttatc atagctgtga aggatagacg 3405901 tgccgttaga gagcgtcatg tttgtcaatt ggtctgcctg atcatacgta taggttgttt 3405961 tttcaccttt tgcatctgtt tcagacgttt tcttaccagt ttcatcgtaa tcagttgaag 3406021 tggcgtaacc tagttcgtcc tcttccttgg tcacatagtt gccattactg tcatacgtgc 3406081 ttttagtcag aaggcttcct tcaatcaaac ggatatcatc aaaccagact gtgcctgtcg 3406141 cactcttttg gaacagaata ctgatatcga ctttattgat cggctttgtt ttagggatga 3406201 cgacagctgc tcggttccat tcctgtgttc cagaagggaa tttcgcattg tagatgcctg 3406261 tgctgccgtc agcgtaagtg acattcgcct gcagagaata gtctttttca tctgtaaatt 3406321 tgacgctgct tgctttcgac attcctgtca gtgtgagata aaccggtttg tcatttgcgc 3406381 tttgccctaa gacaacggtt tgttttgtta ctgatccggc ttgggacgca ctggtccggg 3406441 cagcttttaa tgatacatca tcattaaagc cttcttcaga atcaacggat gctccgctta 3406501 cattccagtt ttccgttgct gatgtgaagc tgctgttttg aactgggtta tagcttgatg 3406561 atacttcgcc tttttccagc tggacttcat caaaccatgc ttttcctttg ccatctttat 3406621 ctttatgatc gacttccata tacacaacag ctttgcctgc attcgctgga gtcgtaaaag 3406681 tgatttgccg ttttgtccag tcattttttc cggctaatgc actgtattca ttgtgaatcc 3406741 attgaattcg tttttgatct ttgtctcgca aatcaatgtt aaaataggct cttgatttcg 3406801 caagatctgt tttgattttc ccgcttaatg tataggttgt attcggctcc agctcaactg 3406861 tttgtgttgc tgacgaatac ccatgatctg ttccggcaga cgttgattgg ctcaagacct 3406921 ccaatgcctt tgatccggaa agaactccgc ttttatcggc gatgactgaa attttgccgc 3406981 tgtctttaga ggcagtcaga ttccagccgg atttttgagc ttcaaagctt ccatctttca 3407041 aaatattagt tgaagctgat aaatctttgc tcgattgaat ctggtttcca tatttatcat 3407101 aaacagctgc tgacgatgat tttccgctct gatcggtttc ggatacagca tccagtccgt 3407161 cataagcaat atccgtgaca ttgccctcgg tatccttcat ctttgtgaca tcgttgtttt 3407221 tgttgtattc gtatgtctca gttccatatg catctttaac cgacgtaacg ttgccatctt 3407281 tgtcatattg atagctttcc gttgcttttc cggtgccgac gtcatttgga tctacatctt 3407341 ctacaacatt gttgccttca tactttgtat tcgttgtaat ttttaaccct tccgcatcat 3407401 caatgacctg aatcggattt cccgcttcat tatagccata ctgtactttc cggccatttg 3407461 gctgtgtcat gagaagcgtc tttttatcag catcatagct gtagacatat gtttcttttt 3407521 tagcgttgat cgctttttcg agacggtgac cgctatactg atattcggta aagacaggct 3407581 ttgcttcggt actgttagct gaatattgtt tgacaaggcg cccttcacta tcgtagtcat 3407641 agcttgtgac agtcccgtct gtatctgtaa ccttcttcag caaatcattc tcatatgagt 3407701 aggtgacttt cttattctta ggtcctgtga tggacgtcac atggccgttt tcatcatagg 3407761 taaatgtaag cttgcggcct gatgcatctg taatggcggt cagttgattt ttgtcattgt 3407821 aagtatagac agttgcattg ttatggccat ccactacctt ttggagtttg ccgccttttt 3407881 tattgaaata agcgttggtt tgatcctttg tttttaatat gaactgatca gctgtttctg 3407941 ttaattcaag atatacaccg gtcggcggct gatacgtgcc atcggctttt ttcgtgaatc 3408001 gatgtgtcgt agcgtcttca tcgatataca ttgccccgcc atccgttgag atgacagatg 3408061 tttctgcatc agcataccag ccttgtccaa ataagtgatc agagctgtca agactgttgt 3408121 aggttctcga taagccaagt cccggaccgc gtccatcaat tgacaaatct tcttcattca 3408181 caatgacatt gcctgtcgca ccatttaact ggccgcttgg gatatcaatg atagaccagt 3408241 actcttctgt acctaggaat tctgcgcctt catggaacgt tgggttaaag ggcgccgttg 3408301 gaatcgtttc accattcgca tcataggcga caagcgtgaa agaataattc ttcttccctt 3408361 tgtaattccc atttgcattg ttatagacag gtgatggatc gagggctaat tccccgcctt 3408421 ttccatctgt atgaagctta tagcttccgg ctttgatttc ctcagaagtc ggccagatgt 3408481 ttttattttg ggttgtccaa tgatcagcat caccaacatc aaaggactga tattctttac 3408541 cgttgtaaat gttaacttta tagcccttcg cattttgaac cttttcccat atcaaattca 3408601 cataacccgt ttgactcgat tttgtatttg tatacaaata gccagttaca ttctttggcc 3408661 tagcgatatc aggaagtgcc ggggtagcag ccggggatgc aatggcttcg ccgtctttgt 3408721 tgtatgcgat aattttaaac gagtaatttc ttttggctcc atctcccccg gcgtttttat 3408781 aggttggtcc gggattgatc ggcagctctg ctccgcttcc gtcctttagg tgaagagcat 3408841 attttcccgc cttgatttct gcacttgtcg gccagatctt tttccctttt gtggtccaag 3408901 acgtctgatt tccgagatca agtgtctcaa agcctttccc attgaacacc tgaaccttat 3408961 agccggttgc accggataca gctttccaag aaaggtcgaa gtatcctgtg gcattcccat 3409021 tattgtagcc ctttgctgac ggtgcttgtg cttttcctac attagggata acgggctttg 3409081 ccggtgcgga catcgctcct tcaccttggt caaatatcgc actgacgcca atccaatagt 3409141 ttttgcttgt agcatagctt ccgccggaat tcttatagac cggggatgga tctaatgcca 3409201 attcagctcc atccttgccg tccagatgca gtttatatct cttggaggca atttctgcgc 3409261 tcgtaggcca gattttttta ccttttgtgc tccacgacgt gacgttgcct gcagaaatcg 3409321 cttgatattc cttaccattg taaatccata ccttatatcc ttttgcgcct tcaacctttt 3409381 tccagctgat atcgaaataa ccagtggaat cgccgttgtg ataggctttg attgtaggtg 3409441 tgtttccctt tggaatggta tacgtcactt caatatatgg tttattggcg gagttcgctg 3409501 aagaaattag ttttttccaa tattccttgc cgtttccgtt tgtatgaagc ttaaatccat 3409561 agttggcccc gccggagttc catgacttta cagcagcggt cacatcataa ctcgcccact 3409621 gtcctttatg gacgtcggct tttccgatat ttttagatgc cggtttggtg ttccatgtca 3409681 cttttgcatt atcataattg ctgttgaccg tatccagcca aaggccggtt gcctttgttc 3409741 cataatagga atgggctacg tatgttttta atgtagcttt agtgacagtc atattttgaa 3409801 ttggctttag gttgttaaat ttcatgaacg catagtttgt gcctgttgtt ttgtcataat 3409861 agcccgtttt cagtacatag gcctttaaat tagcatccca tttttgtgag gaggccgaat 3409921 agttcgtcgt cgggtaggca ctcatgacaa acgtatccga tgaaacagat aaagaagttg 3409981 acgggtcgat agatactgga tatacgcgtt ctgggtcttt cagccagttc tcgtctgccg 3410041 taagatgaag caaataccct tcttcattct tttccagctt atagctgact ttgtctgacc 3410101 gttcaacctc gccggaaagc tcatctagtt ttgaatccgt cataaaaggc ttaggcacag 3410161 aaaaaacaac ttttcctttt tcatcagaaa aatcaatgga tccatcctct tgttctttag 3410221 cctgcaaatc ggtttttaac tgaaatgtaa atgtgttgta tccattatac tgatgaagga 3410281 ctaaatcttc ttttatgttt tcattgaatg tgaaagtctg aagatcaata ttcggaaaca 3410341 catccggata cacaatctca ttactgtcag tcttataatc tgctgaggta tctttcggag 3410401 taagtgaagt tttattcggg cctttcgctt ctgctagtga atatgtaacc ttatggtcat 3410461 tatgctcaaa agtcgcataa agcccgttct tcatttgctt ttgaaaatct gaattcaaaa 3410521 tagcgttctc tgtctcgact tgtttgcttg tcgactcttt taactcagga gaaatgtctt 3410581 cccagtcggc atccggtgtt tcctttgtat gaataggatc aaggtatact tcctgtttat 3410641 agacaccgtc accttcataa tagagttttg tattttctgt tctttcagag gtgatctcac 3410701 cctctttgtt tatatctttt ggatcaaaag gtacagcttc ctcagtttgt tctttctgaa 3410761 gagtttcttc tggatcatcg gcagcaatac ggtttccatt ctcttcttct gtagattttg 3410821 ctagtacatc ggctggcact aatgaaatca ttaaagccaa cactaaaaat gctgcaatga 3410881 accttttaaa gtttcgcctc tttctttttt tcatttcctc tctccttttg taataaaagt 3410941 aatatttact caataatctt aactagactg aaatatcatt acaatatttt tctagaaaat 3411001 ttatcttatt ttaaggatta gcgagagtca attgacctaa aacaaaaaaa ggccgcatag 3411061 gcctttttac attttttatt gtatttgttc aatatccgta ccctcagctg tcacattcgc 3411121 cttcccctgc ctcctgacaa gcgtcaaggc catgcccgca aagatcatta cgatgccaag 3411181 cgtttgatag aggtcagggc ggaagcctgt gaagacggta tcgagcacga tcgcgacagc 3411241 ggggtcgaga aatacaatga ttgaaataaa tttcgttgat aaaaatcgta aactgtcaaa 3411301 aaacagcaaa tatacaatac ccgtatggat gatgccggta gataccacca taatccagtt 3411361 tccctgagat aggtccgcaa aagcgccaaa gtgaataaac ggaatcagga tgataacccc 3411421 taaacctgtc tgcaagaagg tggtcgtgta aggactgaga ttgtgaatgc cttttcccaa 3411481 taaagtggtg aacgcataaa acagtgcggc gagaactgcc catatgatcc ctgatcccat 3411541 cagctgtgtc aatgatgtgc tgccgttaat cccggaaatc agcgcagtcc caagaaagca 3411601 gatgataatg gagctgacgg agatcacatt taatttctct ctgtagaaga agctccccag 3411661 aagaagaaca agcaccggcg ctagatgata aacagagatg gcaattgtaa cggacgtttc 3411721 ttcaaaagac ttaaataaga acacccagtt gaatacaaga aagaaaccgc acgccaatgt 3411781 ttgcagcacg tctctcttgc tccatttttc agttttatac tggccggacg ccagccagca 3411841 aaagcctaaa aacagcgtcg cgcaaaggca gcggacaaag accaattcaa atgacggcag 3411901 attggtatgc tctgagaaaa agccgatgga gccgaaaatc accatagaga tgaccatttt 3411961 gattacggct gttgattttt gttttgacga tatggaagga tcctgttgca tcaaacgtat 3412021 tctacctcca atactgcata gcataaactg ttttttgtga attcagaaat ctacacatag 3412081 aattcctctt ttttacatgt agatattata acacttctat tctaaataaa aaaaagcgcc 3412141 caagggcgct ttttttacaa atctatcgaa caatcaaaac cgggcatgtt gataattgag 3412201 acactttatg gctgacgctt ccaagcatca tttctttcag gccgctgatc ccccggctgc 3412261 caactacaat caggctgacg cctttctctt ttgcgtgatt tagtatctca tgcgccggct 3412321 cgccattcgc gtaaatggtt tcagcttgaa cgcctttttc ggctgctttt tcttttgcat 3412381 tctcaaggat tttcaggccc tcttttttaa cctcgttcct gatttcatca ataaagtgtt 3412441 caggcacata gacaattccc gtcagagaag aagtcgtgac gacggcttct ctccccacat 3412501 gaagaatgct tagttccgct tgttgctctt ttgccaaatg cactgcggca tcaagcgctt 3412561 ttgcactcat gtctgatccg tcaatcgcta ctaacatttt gttaaacatg ctcttcccgc 3412621 ctttcggact gtgggtggtt catctttctc ttttattgtc cgcctgcatt tcgttattgt 3412681 caattgaagc gcatgagttt tcaaaaaatt gtcagagact ctctccgttt gtggcgataa 3412741 cctgctgata ccagttgaag ctttttttct tgatgcggtt aaatgttcca tttccttcat 3412801 tgtcccggtc tacataaatg aagccgtagc gctttttcat ttccgcagta gatgcgctga 3412861 caaggtcaat tggcccccat gatgtgtatc cgattaattc aacgccgtcc gcaatggctt 3412921 cgcgcgcttc aattaaatga tcacgcagat agttgattct gtaatcgtcc tgaatcgtgc 3412981 cgtcctcttc aaccttgtct acagcgccaa ggccgttttc aacgatgaac agcggcttct 3413041 ggtaacggtc gtataaggtg ttgagcgtga tgcgcaagcc tttcggatca atctgccagc 3413101 cccattctga tgatttgagg taagggtttt tgactccgcc cagcaggttg ccccctgatt 3413161 ttgcaagctc ttccggatct gtgctcgccg ccatcgacat gtagtagcta aatccaatat 3413221 aatccaccgt atgttctttc aagagctctt catcgccttc agccatttca atttcaatat 3413281 tgttttctgc cagatagcgt ttcatatatc ccgggtatgc gcctcttgcc tgaacatctg 3413341 agaagaaaag tgttttgcgc tcattctcca ttgccgcgaa gacatcctcc ggcttagaag 3413401 tcatcggata ggttgtcgtt gccgctatca tacagccgat tttcgaatca ggaatgatgt 3413461 cgtgacccgc tttgacagca agagcactgg ccacaaattg gtggtgtgcc gcctggtaca 3413521 tcgcgtttaa tttgttttct ccttcttcaa aaacaagacc gcctccggta aatggcgcat 3413581 ggagcactac gttaatttca ttaaacgtca tccaatactt cactttgtgt tgatagcgtt 3413641 tgaaaaccgt tttggcatag cgttcataaa actctatgac tttgcgattc ttccagccgc 3413701 cataattttt cactaaaccg agcggcatct cataatgaga gatggttacg acaggctcaa 3413761 tatgatgctt taacagctca tcaaacagat catcataaaa tctgaggcct tcttcattgg 3413821 gctcctcttc atcgccattc ggaaaaattc tcgtccacgc aatcgatgtg cggaacgcct 3413881 taaatcccat ttctgcaaat aaggcgatat cctctttata acgatgataa aagtcaatcc 3413941 cgttgtgata cagattcaag gaagtcattg attcatcaaa tggagacatg atcccgttcg 3414001 gcgatacgtc agctgtcgaa agccccttac caccctcgtt ataagcaccc tccacttggt 3414061 tggcagcaac tgcgccgccc cataaaaatc cttctggaaa tcgtttttca tttgaactca 3414121 tattgatcac cccattagtt ttttcaagat aaagcaagca gcgcttcttt tggctgcact 3414181 ttaccgatct ctttcaccgg cgaaaacgaa tattggtctg tgttggtcac aatcaccggg 3414241 gtaatgacgt catatcccgc ggctttgatt tgctccagat caaaggacac gagcggatct 3414301 cccggtgcga ccttgtcgcc ttctttgatg tgagccgtga accattgtcc ctccagcttt 3414361 accgtgtcca atccaatgtg tatgagtatt tcagctccct gatcactcgt aatgccaatt 3414421 gcgtgttttg ttttaaaaat ggtggtaacg cttccacgaa caggcgaaac aacttctcct 3414481 tcttcaggct caatggcaaa tccttttccc atgaccccag cagaaaacac tccgtctttg 3414541 acttcactta aggctttcac ttctccctta atcgggctgt gaatgatctc tctgctgcct 3414601 tcatgcactg ccggctgctg gctgccgtca gaaggcacat cctcgaatcc aagcaaatac 3414661 gcagctgctg ttcccgccgc aaacgcaatc acaaggccga tcatcgcgta aataaacgtt 3414721 gggccgataa agacagggat gctcggcaga cctgcattcc ccccgacgat ataggaagca 3414781 acacccgtca tgccgtaaaa cgcgccaccg gctgcaccgc caatcaaagc ggccgcaaac 3414841 ggctttttca atcgcatatt cacgccgtac atcgcaggtt ctgtgatccc catcagcgcc 3414901 gtgatgcttg tggtaagcgc gagtgattta aattttttgt ttctagagcg aaggaagacg 3414961 gcaaatgatg ctcccgcctg ccccatattc gccaaaaaca tagccggcag taaataatcg 3415021 tggccgtttt gagcgatgtt gttgatcatg atcggcacaa aggcatagtg catgcccgtc 3415081 ataatgatta aagagaatgt acccgccagc aaaatcattg ccacaagccc tgcatgatca 3415141 aacaaataat tgaccccaga agacaagtat tctcctaaaa tagcgccaag cggaccgact 3415201 gtaatcaatg tcagcggcac gacaatcaat agcgtgaatg tcggaaccac aatcaatttg 3415261 agagatgcgt gtgtaaaacg gtcaatccat ttttccacgt atgaagcaat ccaaatcgac 3415321 agcaaaatcg ggatgaccgt tgacgaataa gtggcagcgg ttacaggaag cccgataaag 3415381 gaaatcggtt tccccgcacc gagcagggct gtcaaatccg gatgcaggat cgccgccgca 3415441 atggcagccg ctacgtacgg attgcttccg aattttctcg ccgcactcat cgctagcagg 3415501 agcggcagga agtagaacgc accgtcaccg acagccgtca aaatgacatg aacctggctc 3415561 ttctccgcca tccagccaaa cgtgactgcc agcgccacaa gtcctttgat catccccgct 3415621 cccgcaatcg caggcagaat aggggtaaac accccagaaa tcacatcaaa gaccgcactc 3415681 agcacattct ttttctgaga ggatgaacca gcgctctttt catcactgag attgctgtgc 3415741 cgcacaatcg cctgatacac cttcggcaca tcgtttccga taatgatttg aaactgctcg 3415801 ccgctgatat tggtgcccat cactccaggc agctgctcca gctgactgcg atccgccttc 3415861 gcgttgtcat gaagattaaa acgcagcctc gtcatgcagt ggatcacgcg ctgaacgttt 3415921 tcttcaccgc ctacgagttg taatatgtcc ttcgataatt tatcataatc catgtgtata 3415981 cctccttttt atggggggac tgctggatga aaggtggccg cctttcacca gctttttttg 3416041 tatcaaatgc tgcatcacct cctaaaagag aataaaaaaa cctaaatgac acagattgcg 3416101 agagtctcct cctgcacctg caccatttag gttttgcctg ctttcgcagt aacaatcctg 3416161 acgggtcgtt ttatttgttt gtaggtatac tttagcacta gattcgtgag atgtcaacgc 3416221 tttcattttt ggtgttgact atcgtttcta gaacaaaagt aatcataaag atttgaactt 3416281 agtattaact tcaataaaaa attattgtaa ttaaaaacct tgaaaggcat tttttccaat 3416341 caaggttatg aatcgttacc gtttaaattt ttttaaagac ttctttatct gtactattac 3416401 attctttagc caatctattg gttctaaatt aaacgcagga agatacacgc catctgcgca 3416461 agattgaatg taatcgtttt tcttattgtc tgaatgctca ctttcaataa aatccgttaa 3416521 aaagacaata gcatcctcca aatattcctt actttcctct attaataact cttgtatagc 3416581 gtcatcagga gtttcaatat cttgatggaa tgttccagct aaaaactgaa aaacagggtc 3416641 cttctgttta ttgatcaata acatgtcatc ttgctccttt aagggagagg taacgggata 3416701 atgttaaaat cattcatcat ctaataaatc aagataatac tgatcattct cttctatttt 3416761 tcttaagaac tcggtaagag aagttgcaat ttgaatatca taatagtaaa tcggattttt 3416821 attattatca tttaattcaa ttgacattaa tgccgattca ctaccttcaa aaaatattaa 3416881 tttatcattc tcaaactcat catatatttc tatgtcagga taaaattcaa agtcatttat 3416941 cctcaatcga aagtctctta cagaatatgg atccaaaatg cgattagtat taaactctga 3417001 tcctttaata aacccatagc caacttctaa ataaaaattc actaattcac taggtaattt 3417061 taagtttaaa tttttttcaa cctcttcaat ctcactttga ttcactggat aaaaatcatt 3417121 ttctttgttt gattttataa aattataact catttttttt tgcctccttt aaataattca 3417181 tttgctggtg agcctgtacc atgaatccca gcttgatgct cgttaggaaa ttttgctgga 3417241 tgcatattcc accattcatg ttctccgcca aaagtatttt caattatatg gtgagcatca 3417301 tacttatccc ctttttttct aataatttta cctgtttttt cagatacaac attttcctta 3417361 taaacaggcc atttttgtcc agtgttttct tcccattctt ttataacttt attttttact 3417421 ttatcaaatt tagtcctgtg ttttgcagtc tctattggtg acattttttt atattcttta 3417481 tttcttaatg cttcctttaa tttatctatt tgatttttag gtaattctct acctgtgcgt 3417541 tgttctatat ctctagcata cttttttatt aaatcagaat taattttatt agcagatcca 3417601 cttacatcat tcgcaatttt ccctttatcc ttagcaacgt ttttaacttc cgaagccttc 3417661 ttagcctttt tcccattatt aataagttta ttaatatcta ttaacttttc taacttagct 3417721 attttggcaa atggtactga gtttatggag gcaacaacac ggtctttccc tgtgactttt 3417781 tcgcctgata ccggatctct gcccgtggct gctttaaata gatcatacac gccggtaagt 3417841 tctacagccg tctctaaaat tttcacatat ccattctcat ccactttaat gtccgaaagc 3417901 gagacgacag gttcaagctt catgtcatta ccagatatgt atacattgta aagtgtatca 3417961 ttataaacga cttgcttaac ctctgcattt gagaaatcag tttttatatg ttctctatgt 3418021 tcactcgtat tatacacttt accattgata acgatgatat ttttacttac ctttttagaa 3418081 tcacccgttt tgacaactga atccacttta gacttttcat tctcggctaa tttcttcagc 3418141 atcatctcca tcggtgaatc atccgcctgc ttcatttgcg ggttaatcgc gccgaagatt 3418201 tggttgatgt tttcttcttc ctgtgatttc aggatggagc cgcttttgta gcctgtgatt 3418261 tcaattttcg ggccggtgta catggtttcg agctgatcaa tgtatttttt catcgtttga 3418321 aaatctgatt ttgcggcttc tagtgcttgg gtttgctggc cgtcaaattg aaagagctta 3418381 ttcagggtgt ctgaaatcag ccgctcagcc tgttctgttt ccatccgaaa aaaggaatca 3418441 ttgactgtcg gcaggctgac gatgtgatct atggctgatg tctggcgatt gactgcgtca 3418501 gtgagctgct ctgtcacttc tcgtgcatgc ttgaccccat gtctcgcatc gtgtgagaga 3418561 aaagcctctg cgatcatgcc gtgggagtta gattctacag aggaaatcgc atgctgtgtt 3418621 tgtttcagca cttttttgta ttcgtcgata aatatgccaa agaaaaggag aaaaggcttg 3418681 tggcactcct cgtaaaaggt ccggatggca tctccgcctt ttcctttcag cgcatccttc 3418741 atgcctgcca gatgctcaac gcttttttcc agcttctcca gctgttgttt ttgcttgtcc 3418801 agtttctcaa tcgtatgctg aatgccctcg tgaagagcgt ggacatctaa tgttttcaat 3418861 cccttgtcct cccgcgcttt atttcatgga agatgatatg ttttcgtccg tttccttcat 3418921 ggcgtttacc gcgctttccg tttgtgcgat atgcttggcc agaacagacg catatgcttc 3418981 agtgagctct ttgatgtcct tatttaattg ctcgatggac ttcacaacat tcaaatggtt 3419041 tctgcctgag agatgaccgg gcaatgagga cttgagttca gctgaattct tgagctgaga 3419101 aagcccttgc ttcactgtgt catacaccat tttaatttcc tgtgccattt gtgctcacct 3419161 cactttttat gtttttcctt ctctatttca tgctctatcc tcgtgatttg gcgtcttata 3419221 gaatacacat cgccctctaa tgagtggatt tttccttcta tgctttcgat gattccgctg 3419281 acttgatcgc ttttgatttg ctgatatgct ttgttcattc cttcacgaat atcttcaaac 3419341 cgctcagcat gtgttcctct ccatgcctcc cggttaagat gaggccggtg aatgagatgc 3419401 tgggcctcag agaaatcgtg tttgatttgc ctaatttcgt gcagcactcg ttttaattga 3419461 tggatctgtt cctgcttttc atgtaagtcg gcttttaccg aatgtaacaa catttcacta 3419521 tgcatgccgc aacacctcgt gtttctatca aactgtgtaa attctttaca atacagacta 3419581 ttttcatatt acatgatggg tcatattgga taaataggta aaaaggattg tcttgagagg 3419641 tatagaactg gttctaaatt gctaaaaata cgatctcatc accctatgaa aggagaaaac 3419701 aatcatagta gggacttttt atttaagcct ttaatctctc ctccagttct aatttttcct 3419761 cccacttaac tgtttcttat agtcaataaa gctcataaaa aaacaccttc cctcgaaggc 3419821 gcttctccat cttatttaga tccccataca gcctcaccgc tggtattcag cacactaaac 3419881 gtcatgacgt tcttctctct caccgaatcc cactggcgta aaaatacccc gttatacttc 3419941 ttgcctgcta acgtgatgtc ggcggtgttt tttccggttt tcctccatgt tccggtcatt 3420001 tccccggaaa tggtgtggtt tttgttgagc tggatgttga tggtttgttt gatgtcggct 3420061 gagatgtctt ttccgtgctg gataagtttg tatgttcctg tgatgtcttt ttgttttact 3420121 tctttcaatg tttcgcccgc ataacgatat ggtgctgcta ccggccagcc gtctttgttc 3420181 atgaacaatt ggtggactct gacttcgtgt tcttcacccc tgcccgggaa gcgggtgtgg 3420241 aagattaaat aggaacgccc ggttttttca tcatagtatg cggagttgtg gcctggtgag 3420301 acgtacccgg tgcctttttc attttctgtt tcaaaagtgt agctgcccat gagtttgacg 3420361 ccgtatggtt cgatggaacg gtcgtcgaag aatgtgcctc ccttgccgcg gacgtcgagc 3420421 attggattgc cttctgcatc atagtaaggg ccgtccggtt tcttggagcg ggccacacgg 3420481 atgttgtagc cgcctgttgc atcgagaccg ccatatgata ggtataagta gtagtattgg 3420541 gtgtctggat tgtagagaac atacgggcct tcgattctgc tgtggttgcc gccgagcagt 3420601 tttttcccat atccctgtcc aggaagcggg aagcccgttt tcggattcat ttcaagtatg 3420661 aaaatgccgc ctgagtatga tccgtacacc atccacagct tgccgtcttt atcaaagaag 3420721 gtatgcgggt cgacgacatt cggatgtttg gttgcatcat acggtgttcc atcgctgctt 3420781 gtgccttcca ttcctgattt caaaaagatg cctttgtttt tgtatgggcc ttcgatgttg 3420841 tcagcaacgg caacacccat ggcggatctt ggcgaatcgc cgcggcaggc gttgtagtac 3420901 atgtagtatt tgccgtccgc cagctgcgtg acgtcagccg cccaaagagt atcggattgc 3420961 gcccattcga aggtttcttt taattcttca tagacattcg ggataagtgg gttgtcattg 3421021 cttacgctgg tggtcagctg ctgccattgc atgaggtcat tcgatttagc tgaagcgaga 3421081 tgagatccaa aaacataaaa agtgccgttt gtttcaatga tggaagggtc atggacgctg 3421141 acttctttaa atataggttt ttgtgcatag acggagtttg ggagggtgaa ggccatgata 3421201 agagctgcaa gaaaacatac acggaacaat cggttgaaca tctaaacaat tcgcctctct 3421261 tttttattaa attttaaacg cttacatttc tctatgaaga taccccggcc tattaaaaca 3421321 gccgaatgtt ttcatattca tccagatagg tgatttctca cttcacttac atagtcagac 3421381 tgatgtctgt ctgttttgcg cagaacttgt tgcttgcata tcctctcctt catagttcaa 3421441 ctcttttgct gtttctcctt cttgcatcac gtctgttttt ctttcgcgta catgtaataa 3421501 ctgctttgtc aggttttgca tcaactgtga tacagccatt tcgttgtcgg cgttttttaa 3421561 gatgatgcct gattgcccgt caacaccaga gtcattcggc tggctcttta taaaacgcct 3421621 tgcgaaaaat acgacttagt aaacgcatat tgagagttag acagcggcgc ttgcctcctt 3421681 gtctggatat cgtgtgcaat cgctgaaaaa acctgttctg ctttctgcgt cacgctatta 3421741 caatagcaat ctaacttgtt aaagactata aaaaaacctt ttgacttctg ctgctgaacc 3421801 aattaatata atactcagtt aatagttatc agaattttta ggaattgagt gattcatatg 3421861 acactgcata aagagcgtcg gatcggccgg ctgtctgttc tcctgctgct gaatgaggcg 3421921 gaagaaagta cgcaggttga ggagctggag cgagacggat ggaaggtctg tcttggcaag 3421981 gtaggatcaa tggacgcaca taaagtagta gccgcaattg aaaccgcttc caaaaagagc 3422041 ggtgtcattc aatctgaggg ttatcgggag tcacatgcgc tttatcatgc gacgatggag 3422101 gctttgcatg gcgtgaccag aggtgaaatg ctgctgggat cgctgcttcg gacggtggga 3422161 ttgaggtttg ccgttttgag gggaaatcct tatgaaagtg aagcggaagg cgattggatc 3422221 gctgtctcgc tttacggaac aatcggggcg ccgattaaag gtcttgagca tgaaacattc 3422281 ggcgttggaa ttaatcacat atgaaacagc ccatagatct tagacgatag ggggctatgc 3422341 gtgaaaacag aagttcacag catagctcct ttttgtatgg gcgctttacc aaagtaaaga 3422401 aaaaggagtt gggcttatgg tgactttaga cggttcttca ttgacaacag ccgacgtcgc 3422461 tcgtgtgctg tttgattttg aggaggcagc ggcttctgag gaaagtatgg agcgcgtgaa 3422521 aaaaagcaga gcagcagtgg aacggattgt acgcgacgaa aagacaatct acggcatcaa 3422581 caccggattt ggcaaattca gcgatgtcct gattcagaaa gaagactcgg cggcgctgca 3422641 gctgaattta atcctttctc atgcctgcgg agtcggcgac ccttttcctg agtgtgtttc 3422701 cagggcaatg ctgcttttgc gcgccaatgc gctgttaaaa ggcttttccg gtgtacgcgc 3422761 tgagctgatc gagcagttgc ttgctttttt aaataaacgc gtccatcctg tcatccctca 3422821 gcaaggatca cttggcgcaa gcggagatct ggcgccgctt tcccacttgg cgcttgcgct 3422881 gatcggacaa ggagaagtct tttttgaggg ggaaagaatg ccggcaatga caggcttgaa 3422941 aaaagcaggt attcaaccgg taacgctgac atccaaggaa gggcttgcct tgattaacgg 3423001 gactcaggcc atgactgcaa tgggggtggt cgcctacatc gaagctgaga aactagccta 3423061 tcaaacagaa cgaattgcca gcttaacgat tgaggggttg cagggaatta tcgatgcatt 3423121 tgacgaggat attcacttag cccgcggcta tcaggagcag atcgatgtcg cagaacgaat 3423181 tcgcttttat ctatctgaca gcggcctgac aacctcccag ggagaactgc gggtacagga 3423241 tgcctattca ttgcgctgta ttccgcaagt acacggtgcg acttggcaga cactaggata 3423301 tgtcaaagaa aaattagaga ttgaaatgaa cgcagctaca gacaatccac tcattttcaa 3423361 tgacggtgac aaagtgattt ccggcggaaa ctttcacgga cagccaatcg cctttgccat 3423421 ggattttctg aaaatcgcaa tatcagagct tgcgaatatc gcagagcgta ggatcgaacg 3423481 acttgtgaat ccgcagctga atgacctgcc gccgttcctg agccctcatc ccggtctgca 3423541 atccggtgca atgatcatgc agtacgccgc ggcctcactc gtttctgaaa ataaaacact 3423601 ggcccatcct gcaagtgtgg attccattcc gtcatccgcc aaccaagagg accatgtcag 3423661 catgggaacc atcgccgctc ggcatgctta tcaggtgatc gcaaatacaa ggagagtcat 3423721 tgcgatcgaa gccatttgcg cattgcaggc tgttgaatac agaggcatag aacatgcagc 3423781 gtcctatacg aaacagcttt ttcaagaaat gagaaaagtc gtgccgtcca ttcagcagga 3423841 ccgtgttttt tcctatgaca ttgaacgctt gactgactgg ctgaagaaag aatctttaat 3423901 acctgatcat cagaataaag aactaagggg gatgaacata tgactgatgt aaaaaaatca 3423961 atccgtgcca acagaggaac agagcttgaa tgcttaggat gggagcaaga ggcagtgctt 3424021 cggatgcttc gaaacaacct tgatccagaa gtcgccgaga agccggagga cctcatcgta 3424081 tatggcggga ttggcaaagc cgcacgggat tgggacgctt ttcacgccat tgagcattcc 3424141 ttgaaaacat taaaaaatga tgaaacattg ctcgtgcaat ccggaaagcc cgttggcatg 3424201 ttccgtacac acccgcaggc ccctcgcgtg ctcctagcaa attctgttct tgttccgaag 3424261 tgggcagact gggagcattt ccacgaactt gagaaaaaag ggttaatgat gtacggacag 3424321 atgacggctg gcagctggat ttacattggc tcacaaggca tattgcaagg aacctatgaa 3424381 accttcgctg agctggcgcg acagcacttc gggggcagct taaaaggaac gttgacgctg 3424441 acagcgggtc tcggcggaat gggaggcgcc cagccgctgt cagtcacgat gaatgaaggc 3424501 gtcgtgattg ccgtcgaggt tgacgagaaa cgcatcgaca agcggatcga aacaaaatac 3424561 tgcgatcgaa aaacagcatc gattgaggaa gccttagctt gggctgaaga ggcaaagctg 3424621 gcaggaaaac ctttgtccat tgcacttctc ggaaacgcag ctgaggtgca tcacacactt 3424681 ttgaaccgag gcgtcaaaat tgatattgtg acagatcaga catctgccca tgacccttta 3424741 atcggttatg ttcccgaggg ctattccctt gatgaagctg accgtttgcg tcaagacact 3424801 ccagagcttt acgtgcgcct tgcgaagcaa agcatgaaaa aacatgtcga agccatgctg 3424861 gcctttcagc aaaagggctc tattgtattt gactacggca acaatatccg gcaagtcgca 3424921 aaggatgaag ggctggagaa tgccttcgat tttccggggt ttgtccctgc ctacatccgc 3424981 cccttattct gtgaaggaaa agggccgttc cgctgggcgg cgctttccgg agatccggca 3425041 gatatttacc gtacggatgc gttattaaaa gagctgttcc cgacaaataa agcccttcac 3425101 cgctggattg atatggcaca ggaaaaagtc accttccaag gcttgccgtc ccgtatctgc 3425161 tggcttggat atggagaacg aaaaaagatg ggcctcgcca ttaacgagct ggttagaacc 3425221 ggggagctaa aagcgcctgt cgttattggg agagatcatt tggactgcgg gtctgtcgcc 3425281 tctccaaacc gggaaacaga agcgatgaag gatggaagtg acgctgtcgg tgattgggct 3425341 gtgctaaatg cgcttgtcaa cacggcggcg ggtgcaagct gggtttcctt ccaccatggc 3425401 ggcggcgtcg gaatgggcta ttcccttcat gccggcatgg ttgcagtggc cgatggaagt 3425461 gagctggctg acgagcggct cgcgcgggtc ttaacgagcg acccaggaat gggcattatc 3425521 cgtcatgcgg atgcgggtta tgaacgtgcc gttgaagtag cgaaggaaca ggacattatc 3425581 gtgccgatgc aaaaataaag gagtgatgac atgccaaagc aaattgatac gattctcatc 3425641 aacatcggtc agcttttgac gatggaaagc agcggtccgc gggcaggcaa aagcatgcag 3425701 gatcttcatg tgatcgaaga cgctgttgtc ggcatccatg aacagaaaat tgtgttcgcc 3425761 ggacaaaaag gggctgaagc cggttacgag gcagacgaaa tcattgactg ttcgggacgc 3425821 cttgtaacgc ctggcctcgt tgatccgcac acccatcttg tatttggcgg atctcgtgaa 3425881 aaggagatga accttaagct tcagggcatt tcatatttgg atattctggc gcagggcggc 3425941 gggattctgt ctacagtcaa ggataccagg gcggcttcag aagaagagct gctgcaaaaa 3426001 gcccattttc atctgcaaag aatgctgtcc tacggcacaa ccacagcaga agtgaaaagc 3426061 ggctacggct tggaaaaaga gacagagctc aaacagttgc gtgtcgcaaa gaaactgcat 3426121 gaaagccagc ctgttgacct tgtttccaca tttatgggag cccatgcgat tcctcccgaa 3426181 tatcaaaacg atccagatga ttttctggat caaatgcttt cccttttgcc ggaaatcaaa 3426241 gagcaggagc tcgccagctt tgctgatatt tttacagaaa caggcgtttt tacagtcagc 3426301 caatcccgcc gttatttaca aaaagcagct gaggcaggct tcggattaaa aatacacgca 3426361 gatgaaatcg atccgcttgg aggtgctgaa ttagcaggta agctaaaggc cgtctcagcc 3426421 gaccatttgg taggtacatc ggacgaaggc ataaagaaat tggctgaggc aggaacgatc 3426481 gccgtcctct tgccgggcac gacattttat cttggcaaaa gcacatacgc cagggcaaga 3426541 gctatgattg atgaaggtgt atgtgtcagc ttggcaacgg attttaatcc tggcagctcg 3426601 ccgactgaaa atatccagct gattatgtcc attgccgcgc ttcatctgaa aatgactgca 3426661 gaagaaatat ggcacgcggt cacagtcaat gccgcatatg ccataggaaa aggagaagaa 3426721 gccggtcagc tcaaagctgg ccgctcagct gatcttgtca tttggcaagc cccgaactat 3426781 atgtatattc cgtatcacta cggggtcaat catgtacatc aagtcatgaa aaatggaaca 3426841 attgttgtca acagggaggg agccattctt ggataagtac ccttttctca gagaggccgg 3426901 atcttcgttt aaagaccggg atgtcacaaa aatgagcgac ctgatcgcaa catgggacgg 3426961 ccaggacatt aagggaccgg cgttgatagg tgtcccccta tcaaaatcct ccatcagtca 3427021 ttcaggcgct tcctttgcac ccggaacaat acgccaggct ctgaaacatt catcagccta 3427081 ttctgctgag cttggagagc acgtcgtatc agagcttcta tatgacctgg gggatatcga 3427141 tattcatgtc actgatatcg taaagtcaca tcatcacatt ttccaaacca tgcacgctct 3427201 gctttcggat catccggatt gggtgccgct catacttggg ggagataact ctatcagcta 3427261 ctccacaata aaagcgatag cacaaacaaa aggaacgaca gcggtgattc aatttgatgc 3427321 ccatcacgat gttcgcaata cggaggacgg ggggccgaca aacggcaccc ccttccgccg 3427381 ccttttggat gaagagatca ttgaaggtca acatttgatc cagctgggta tcagagaatt 3427441 cagcaacagc caggcctatg aagcatatgc aaaaaaacat aacgtgaaca ttcacacgat 3427501 ggacatgatc cgggaaaaag gactaatccc aacgataaaa gagattttgc ctgttgttca 3427561 agataaaaca gatttcattt ttatatctgt tgacatggat gtcttagacc agtcccatgc 3427621 acccggctgt ccagcgattg gcccgggcgg cctctataca gacgaattgc ttgaagcagt 3427681 caagtacatc gcacaacagc ccaatgttgc cgggattgaa attgttgaag tcgaccctac 3427741 cctcgatttt cgagatatga caagcagagc tgcagctcat gttctgttac acgcattaaa 3427801 aggaatgaaa ctctccccat tcaagtgatc ttctggcagg ttgtattttg ggtataagaa 3427861 actcatctgc ctaaggaatg gcagctaaaa ggagggcgag acagtgaatc ttcaggagaa 3427921 cagcagccaa cagctaaaac gcacaatgaa aagcaggcac ctatttatga tctcattggg 3427981 aggcgtcata ggcacaggac ttttcctcag tacgggctat acgctacatc aagccggacc 3428041 cggcggtacg atactcgctt atgtaatcgg cgggttgatg atgtacctcg tcatgcaatg 3428101 tctcggcgaa ttgtcggttg ccatgccggt gaccggctct tttcaaaaat atgctacaac 3428161 atttatcggt ccatctaccg gttttatggt cggcatcatg tactggatca attgggtggt 3428221 gacggtaggc tctgagttta ccgcatccgg tattctcatg cagcgctggt tccctgacag 3428281 cagtgtatgg atgtggagtg cgatttttgc agcccttctt tttatatgca acgcattttc 3428341 agttaagtta tttgcggaaa ctgaattttg gttttccagc gtaaagattg tcaccattat 3428401 tttatttatc attttaggag gagccgccat gtttggcctg atctctttaa acggaacggc 3428461 ggatgctcct atgttgtcaa acttcacaga tcatggcggg ttgtttccaa atggctttct 3428521 cgccgttttt atcgcgatga tatctgtgag cttcgccttt tccggtacag agttaatcgg 3428581 cgttacagca ggagaatcag caaatcctca aaaggatata ccgcgatcca tccgtaatgt 3428641 cgcatggaga accgtgattt ttttcattgg cgctgtcttc atattatccg ggttgatttc 3428701 atggaaggac gcaggcgtga ttgaaagccc gtttgtcgcc gtatttgcgg agatcggaat 3428761 tccttacgct gctgatatta tgaatttcgt aatattaaca gccttgctgt ctgtcgccaa 3428821 ctcaggctta tatgcttcga cccgtatgat gtggtcttta gcaaatgaaa acatgatcag 3428881 ctcccgtttt aagaaagtga catctaaagg cattccttta aatgccttaa tgatcagtat 3428941 ggctgtatct tgtttatctc tcgtttccag tatcgtggcc cctggaactg tctatgtggt 3429001 gatggtcgca attgctggat ttgcaggagt cgtggtctgg atgagcattg ccttgtccca 3429061 actcttgttt cgaaagagat ttttgaaaaa agggggggat gtaaaagatc tgacatttcg 3429121 cacgccgctt tatcctctta tgcctatagc cgctctctta ttatgttctg cttcttgtat 3429181 cggtcttgct tttgatccca atcaaagaat cgcacttttc tgcggagttc cttgtatcat 3429241 cctttgctat ctcatctacc atttcaaaag aaatgttaca aaagcgaaaa aaatcagcca 3429301 agaggaatat ccagccgatc acatcctata attaaaaaag cacaccccgc tcagcatggg 3429361 atgtgcttta ttttttattc tgtaattaac gtatgaatca gcttcggcgc cttcgcttcc 3429421 gcggcgatgc ggatgttgtc atagactttt gcgatgactt catcgacgtt ttctcggtta 3429481 gcgtaaagcg ttacgagcgg ttcccctttt tctactttgt cgccgacctt tttgcggagc 3429541 atgatgccga cggctaaatc gatttcgtct tcttttgtgg cgcggccggc acctaacagc 3429601 atcgccgcga cgccgatttc gtccgcgacg atttcagaga cgacacccgc ttctttggca 3429661 ggcacatcaa tttgatatgc ggcttgcgga agcttagacg gatcgtcaac aattgagctg 3429721 tcgccgcctt ggtttttcag gaaatccttg aatttctcaa gtgctttgcc gtttttcatg 3429781 acttcttcca gcttcgctct cgcttcgtcc aatgtatcgg cttttttcgc aagcacaacc 3429841 atctggctgc cgagcgttaa gacaagctca tgaagatcct caggcccctc gcctttgagc 3429901 gtgtcgatcg cttctttgac ttcaagcgca tttccgatcg caaagccgag tggctgggac 3429961 atgtctgaaa tgacagccat tgtttgacgg ccgacgttat ttccgatgcg taccatcgct 3430021 ttggcaagtt cagctgcgtc ttcttctgtt ttcatgaagg cgcccgctcc cgtttttacg 3430081 tcaagcacga tggcgtccgc cccggcagcg atttttttgc tcataatcga gcttgcaatg 3430141 agcggaatgg aattgaccgt tcccgttaca tcacgaagcg cgtacagttt tttatcagcc 3430201 ggcgttaaat tgccgctttg gccgatgacc gcaaccttgt cgcggttcac aagtttaata 3430261 aattcatcct tcgtcagttc cacgtggaag cccatgattg cctctaactt atcaatcgtg 3430321 ccgcccgtat ggccgaggcc gcggccggac atcttagcaa ccggcacatc aagagccgca 3430381 acaagcggag cgagaacgag cgttgtcgtg tcgccgacgc cgccggtaga gtgtttatcc 3430441 actttaattc cttcaatggc agaaagatca atcgtttcac cggagttcac catagccatc 3430501 gtcaagtccg cgcgttcacg gtcactcata tcctggaaga aaatcgccat agcaagcgcg 3430561 cttgcctgat aatcaggaat gcttccatct gtatagccgt tcacaaaaaa ttgaatttct 3430621 tcagtggtga gttcttttcc gttttgtttt ttgatgatga tatctaccat tctcatgttt 3430681 ggtcaccgat ccttttcgat taagttcagt aaatcaagcc cacaattgct gctgataaaa 3430741 agctgacaag cgtagcaccg tataataatt tcaagccgaa acgagcgacg acatttcctt 3430801 gcttttcatt cagtcctttt acggcaccgg caatgattcc gattgaggag aagttcgcaa 3430861 atgacacaag gaataccgat acgatcgctg ttgtacggcc gctgaaatgg aaaccgtttt 3430921 gcgtaagcga cgtcatggcg acaaattcat tcgataccat ttttgttgcc ataatgcttc 3430981 ccgcattaac agcttcattc catgggatac cgacaagaaa agcgaatgga gcaaacacat 3431041 atccaagaat gccttggaac gaaataccga atactgcatt aaaaatgcca ttgatcaatg 3431101 caataatcgc gacaaatcca atcagcatcg cagcgacgac aaccgctact ttgaaaccgt 3431161 caagaatgta ttctccgagc acttcgaaga aggattgttt ttcttcttcc tcaacacgaa 3431221 gcatatcctc ttcttttgca acctcgtacg gattgataat agaagcgata atgaaaccgc 3431281 caaataagtt caaaacaagc gctgttacaa catattccgg tttcagcatt gtcatatacg 3431341 caccgacaat cgacattgat acagttgaca tcgcagatgc gcaaagcgtg tacaagcgct 3431401 gctgatttaa aagaccgagt tctttcttca aggagataaa tacttctgac tgccctaaaa 3431461 tcgcagaagc cactgcgtta tacgattcca atcttcccat accgtttacc ttgctgaggg 3431521 caaggccgat atatctaatg ataaacggga ggactttcca cttttgcaga atcccgatca 3431581 gagcggaaat aaacacgatt ggcaagagaa cattcataaa gaatgtcgtt tggtccgcat 3431641 tcaccaagcc gccaaacaca aagttaattc cctctgccgc gtattcaagc aggtaaccga 3431701 atccttttgc aaatcctccc acgaggaaat tccctattcc ggtattgagg agaatgtagc 3431761 caagaataaa ttgcaaaatg agcataacaa caattgggcg gatcttaatt ctttttttgc 3431821 cgctgctcgc gatccacgcg aggcctaaaa acacgattaa accgataatc ccaatcaaat 3431881 acttcatatg tgtttctcct ttatttgtat tcgcttacaa ttactgtttc ctcagaaaac 3431941 ggaaagcagt ctgccttccg tcagctctta atagttgtct ccgcctgatg cattttctcc 3432001 ttttacgata gaaacgcctg cgctggcgcc aattcggctt gctccggcct ctaccattgt 3432061 gtctacatct tctttcgttc tgacgccgcc agatgctttc acgccgatat caggccctac 3432121 tgttttgcgc attaaggcga tatcttcctt cgttgcgccg cctgtagaaa agcctgttga 3432181 tgtttttacg aaatccgctc ccgcagacac cgctaaacgg catgcacgtt ctttttcttc 3432241 atcagtcaga aggcacgttt cgataatgac tttgacaagc gcttttccgg ctacagcttc 3432301 cactacaccg cggatatcag cttccaccac atcgtcttcc ttgtctttta aagcggcaat 3432361 attaatgacc atatccactt cagtggcgcc ttttgaaatg gcgtcttttg tttcgaacgc 3432421 ttttgtttca gttgtattgg caccgagcgg gaagccgatg accgtacaaa cgtcgactcc 3432481 agttccctta agctcttttg cagcaagctc cacccatgtc ggattgacac atactgaagc 3432541 aaatttgtat gttttcgctt cttcaattag ttttagaatg tccgcttttt gtgtatgcgg 3432601 tttcaaagct gtatgatcaa ttatgttggc taatgacatc cttcgcacac ttcctttttt 3432661 gttaagatat tttttagcat aaccgacttt tgaacatatg taaattggta attgaaattt 3432721 tgttcaatga aaggtttgaa cgtgtcacaa atcattaaca agcgccctcg cggtatgctg 3432781 gtcaatgatt aaaacgttgg catattttcc ggttaatgct ccgtgaatgg aagatacttt 3432841 tctgcttccg ccggcaacta aaatggagcg ttccttcagt ctaaggtctt gaagctcaac 3432901 accgatggtc cggtcattga tggcgctgct gcaaatattc cctttcgcat caaaaaagcg 3432961 tgaacaaata tccccgacgg cctgtttttt cagcagggct ttctcttctt cgttaaaata 3433021 tccgagccga aacaacagcg cttcatcacg gacagtcccg accgtaaaga gagcgatatt 3433081 cgcctgcttg cccatctcaa tgatccgttc aatatgacgg tctttctcca ccattcgctt 3433141 cacatccgca ttatcaaaca cgacgggaag cgggagatag cgcggcatcg tttgaaaagc 3433201 ctctgcaaac agctgaatcg tttcagccga atacgtgttt acccgggaat ggctgatgcc 3433261 gcctttcagc tggacgacct cgacgccttt tacctgcttc ggctgcatgt tttgcgcgat 3433321 ttgatacatg gtggttcccc agctgacgcc gacaatgtcg ccgtctttta ccgtttcatg 3433381 catatattct gcaccatagc ggcttaggtc atgtgtaatt cctgcataat cgggtgtcgg 3433441 ggaaaacaca acatgcgcct caaggagccc gtatttctct tcaagtatgg aaccgagcgc 3433501 atccaaatcc tcaaaagggt ccatgacgcg aatctggaca tacccttttt cctttgcata 3433561 ttgcagcagc cgggaaacgg ttggccttga aatgttgagc tgctcagcaa tttgctgctg 3433621 actgtagtca gactgatagt aaagccttgc cgcttctatg cttaattgct gtttttcccg 3433681 atccattctg cacctccctg tggatcagtc ctgataaaac tgcttttgat ttgcttttat 3433741 tatacaggct ggcgccggct ttcatccacc tgatttctaa gaaactgaaa aacgctctgg 3433801 gcgcggacct gcccagagct tacttctccc aagtcatatg ctgataaatg cctttcataa 3433861 tggcgtacat tccatatagg atcaggccta atgccaatat agacagaatc aatttgccat 3433921 gcggctgctg cgcgagttct gcgagcgcgc cgtcaaagcc tcttgtgtcg tcgggatcag 3433981 cggtcatggc tgtcttgatg agaaaatagc cgatagccga gaaaataatg gcccgggcga 3434041 tattgcctgc gcgtcctgtg tttttcgtga tgcatatcat ctgtttgttc atttttgatg 3434101 tatcgaattc tttcataaaa gcagcccgaa cgcctttcat aaattgaaca atcgcaaata 3434161 cgataaaacc cgcacccgta agccctgtga gccattggcc gaacggctgc gccaatacat 3434221 aagcggacca cgtctgttct gaagtgccgc cgtccccttg gccaaacaca aatcgcaagg 3434281 cattccaagc gatggatgtg taaacagcgg cactgaaaaa gtttcctatt ctccgcgaca 3434341 ggcctcgcct gctgtttccg tgcccctccg tgtccttgat cgcgcttaac accatccaga 3434401 tcacatagcc gataaggccg atgcctataa aaaaaagcaa tagtgaccca tacggcatgc 3434461 gtgatagcgt ttggagagct ccgctcgaat ctttggcgcg gcctgccccg gcagccgtca 3434521 taaaagccaa aaccccaagc agaataaaaa cgccgccgaa tgcaaaataa ccaagcctcc 3434581 cgaatcgttt gatccaaggc ttggtttcct gttttatttt tgacatgtac cggtctttca 3434641 ccgccatgtg tccaaccctc tttcacagaa atctttactg taacattccc gattgaacaa 3434701 agttgaaaca gctcctgcct cagctatggc tggctgagat acgtttttgc tgtttagctg 3434761 attgtgcagg tgtcatccaa gcagccgctg cggcagctgt gactccgcct gctaatttcc 3434821 caatgatcat ggccgccgcc atttcttttt tcattccagc tacaaaaccg agatggctgc 3434881 cgagtacaaa ggcgccgctg accgcaaacg cgacattgat gacctttcct ctcggcgtca 3434941 tatcctttaa tgaagccagc attgggatat gatgcgccaa agaggtcact aagcctgctg 3435001 ttgctgtctc atctaaatga aggcatttcc ccagagcctg aagcggtttt ttaaaggttt 3435061 ttgtaataaa tgccgtcatc gggaacgccc ctgccagagc aatggcgatg gtccctgtcg 3435121 tttgtatccc tgtctcgaca ttctccattc ccggaatcag cacaatgccg gtcatcgttt 3435181 caacagaaac agctgcaagc ccgataatcg caaccatact gaccgctttc ccgaagagat 3435241 gaaacaactg aatcattctg tcggtgtatc gccataaccc aaaagcgatg acagcagata 3435301 acagactcgg gatcagaaga tttttaccta tcatgccgat gtcaaagcct gcgcataatc 3435361 cgccgattaa gcaaccgatc ggcactgtgc acagcccgat taatatgcct ttcgcaaaat 3435421 acggatgatc ctctttttcg atgatgccaa gagcgacggg aatcgtgaag acgattgccg 3435481 gccccatcat tgttcctaaa aacacccatg aaaacagccc ggcctgcgga tctttcgcca 3435541 tttctccagc cagcgcatat cctcccatat caatcgccaa aatggtgttc gcaaaggaag 3435601 aaggatccgc gccaatcgct gtgtaaaacg gagcaacaat gggaatcaag attgctgcca 3435661 gcacgggcgc cagcgataca attccgatca tggacagcgc cagcggcccc atagccttaa 3435721 agccgtccgc aaaccgctcg cctagccccc atctgtttcc caaacaataa tccgctgctc 3435781 cccatagtaa aaaggcagcc aaaatgaata caaccgcgtc attcaccgtc atggttttct 3435841 cctttttcaa acgtatgatt ggttttatca tatcatctga aatcaccgaa tagagttgat 3435901 cttattcaat atgagctaaa aattctttta tatcggcttt ttcaacggct gttataatgc 3435961 gtcgcgcttt ttcttgcggg accgttaatg tcaatttttc tattatgtct tcttcagaca 3436021 gctcatttcc tggtgcccct tttgggcagt ccacacgcgc ttcgcaaatc cggccgtctg 3436081 ataaataggc ccggacaatc gtgaaacggc cttttggaac ggcatgagga gccggctgaa 3436141 tagcattgtc atatacgcgc tgaattcgcc ccattgtcgt ttgaaccccg tttgggatcg 3436201 gctggctgct gaaatgttca acggtcaggc cgtgtccatg caaagcaaga gcaatcacat 3436261 attcaacgct gaaacggcct tcctctccag cttttggaga tctttccgtc aatgcagcat 3436321 ctccgcctgg cggaaatatc acttcaatac gttcggtatt ggcagcagaa atggtttctt 3436381 cggagataag ctgtcgtacc gcatctgcag catggtgtgc cgcggaacaa aatggataga 3436441 ttttaaacca tagacccggc tgcacaattc tccacggtgc cccccaatcg tttagcaaag 3436501 tgtgttgtgc tttctcaacg tcaccgtaca gactgaagaa accagtttct ccatcaagtg 3436561 ccgtgcggga cccgccaaat tctgattggg ccagcttaac ggccagcaag ccagcctgag 3436621 ccgccaaacc ggcgtgcagc ggtttcattt ctgttccaaa ttgcaccctc atcccagcag 3436681 attgcgtagc cgcaaaacca attgcttttt ccaactcttc ctgagtcagc tcctcagcat 3436741 aacctacggc gcaggcagca gcgatggcac caagcgtacc tgtattatgc cagcccttct 3436801 catagtggcg gctgccaatt gattctccca gccgtgccat cacttcaaca ccaacaacat 3436861 aagcgccaag aagccgctcg tcatgtccgc gagcggcaga agcaataagg gccggtacga 3436921 tgactgcact ggggtgtcct cttacatcgg agtggacatc atcaaaatcc aatgcatggg 3436981 cgataaatcc attgagcatc gcggattgta atggcgcggc ctttttgccc tgtccgataa 3437041 caggaacaag gggccggcct ccttcatcct ctatcagacg gaggagcttt tgaattcctt 3437101 tatcttctct tcctgcgaat gaagcggcag taaaatcaag taatcccttt tttgcttcgt 3437161 gaatcgcgtc aactgaatgc tcaggttgtg acgttctcac agcctctgca agacctgctg 3437221 tcagcccttg tttgctcatt tgatggtctc caatacaata accgccagct ccgcaaagta 3437281 ttgagaggca accgtaaggg cttcttcatc cagtgtaaag gccggatgat gccactcctc 3437341 cgtcccgttc gttcccatcc agacaaaaaa tcccggaatc ttctcttgat acagagcgaa 3437401 gtcttctccg cccggagact gctcagcgtg aacggtttga tagccaagcc gtgccgcagc 3437461 ttcggatgcc gcattcaaaa atgtgccgtc attctgaacg gaaggcaaat aaggaaacca 3437521 cttgaattct gcttgtgccc catagcccgc tgcaattcct tcagccactc gtctcatatg 3437581 ctcgggaaca gcctgcctcg cttctttttg aaaggttcga accgtcccct ccatttcagc 3437641 ttggtctgga attacgttcc acgaggtgcc cgcctgtact cttgtgatac tgacgactgc 3437701 gttttgcagt gagctgatat tgcggctgac cacagattgc agcccgctga tgatttgtcc 3437761 ggctgcagcg attggatcaa tactgttatt tgggatgccg gcgtgcccgc ctttcccttt 3437821 gatgacgatc tcaaatcggt caacacttgc catgagcgga ccttccttta caccaatggt 3437881 cccgacaggc agatccggct tattgtgcat gccgaaaatc gcagaaacgc cattaagtac 3437941 gccagcttct agaacctttc ttgctcctgc ggcaatttct tcggccggct gaaagataaa 3438001 gcggactgta cctttcagct cggcccttct ttgattcagc aacatcgctg tgccaataat 3438061 agaagcagta tgaaaatcgt gtccgcacgc atgcattgtg ccatcaacct tagatgcaaa 3438121 tggaagattc gtctgttctt ggatcgggag cgcgtcaatg tccgctcgta ttgctatcac 3438181 ggggccgtct tcccgtcctt tgatttctgc aatcacacca gtcttcaatt gagggacatc 3438241 aagtatttcg atttgctcct cctcaagcca acggcggatt tttttcgtcg tttcaacctc 3438301 ttgaaatgac agttcaggat gttcatgaag atcacgccgc atattgatta aacgggtatg 3438361 aaacgctttg tcggccattg ttcttctccc cttcttatat aagctctgca ggctctccca 3438421 cctgcttgat aaatcgtttc gtccgttcgt ttttcggatg gtcaaacagt tcctctggcg 3438481 ttccctgctc gataatatgg ccgtctgcca taaaaatcac ttgatcagca acctcttttg 3438541 caaacgccat ttcgtgtgta acaatgatca tcgttgtttg tttttccgca atggacttga 3438601 tgacctgaag cacccctgtg acgagctcag ggtcaagcgc tgacgttggt tcatccagca 3438661 aaatcgcatg cggattgacc gcaagcgccc gcgcaatgcc gattcgctgc tgctggccgc 3438721 cggacattgt gattggatag ctgtcagcct tatgctccag accgacttgt ttcagaatct 3438781 ccattccaat acgtttcgct tcgtcgcgtg gtttatgttg agccacgatt aaagcttctg 3438841 taatgttttg cagagccgtt ttatttttaa acagattgta gttttgaaag accatggccg 3438901 tttgctggcg aagccgatgt gcttccttgc gtgtaaactt ttccgcattc agtttggctt 3438961 ctccgatttc aataaggcct tgatccggac gctctaatag atttaagcac cggagaagcg 3439021 ttgattttcc ggaaccggac ggaccgatga ttgccaccac ttctccgcgt ttcacttcta 3439081 gatcgattcc gtcgagcacg acgagatctt taaacgcttt gcgaatattt tttactgtta 3439141 tcaactgatt tcacctctaa gtccggtatg gcttgctcat ggcacgttca aacaagtcct 3439201 gcaaaatgct gtagataatg gtaagaaccc aatagacgat cgcaaccgcc aaatacgtct 3439261 caaaatattt gaggtttcct gaagcgtaca tcttcccttg ggcgaacatc tccatgaccc 3439321 ctaatgtaaa ggccagtgac gtttctttca ggagcccgat aaatgtattg cccgttgccg 3439381 gaatcgcatt tcggatcgct tgcggcaaaa taatccgtct gtatgcctga aattttgtca 3439441 taccgacaga caggcacgcc tccagctgcc cgtcatcaac agaattgagg gcggcccgga 3439501 agatttctgc caaataagct gcgtttttta agcttaaccc gatgatggca gctgtgagag 3439561 ctgtcatttt gctcatctct ggaaatagct gcggcagccc gtaatagatt aagaacagct 3439621 gtacaagtgt cggcacgcct cggaaaaagg atatatacag ctttgacagc tgatgaagca 3439681 ctggaatttt gttttttgta atgagtgcga gaataagtcc tccgataatg gcaaaaatca 3439741 tagctgctat tgccataaac aaggtgatcg gaagggcctg aattaaagtc gggaacgctg 3439801 atatcatgaa ttcccaatca atcgtgttca ttctggtgag tcaccgccgt ttcttaatgc 3439861 ttctgttcta ctgtgatatc ttcattaaag tatttttcag agagtttttt cagtgttccg 3439921 tctttacgca attcatctag ggccttattg acttttttgc ggagcttgtc gtgcgcatcg 3439981 tccttggcaa atgggaatgc aacctgttcg taaacaatcg gatctcctgc aagctttaat 3440041 ggcaaaccgg tcttcttgat ttgcgcgatc aatacagttc ggctgttgac ataagcgtct 3440101 acacggccgt acgcaacatc cttcagcgta ccctcttgtg tttcgtacgt tttgatattg 3440161 atttttttat caggatcttt gctttcaagg tttttcgcgt ggtttgaacc gagaacggct 3440221 gcgactgtct tgccttttaa atcgtctact gatttgatgt ctgtattgtc ttttttgacg 3440281 acaatctgtg ttcccgcata agcgtatggt ttcgtaaagt tatacgtttc cttacgttcg 3440341 tctgtcacag ctacctggtt ggaaatggtg tcaagcttgc ctgtttgaag ctctcccatc 3440401 agcccgctga attcaagcag cttccagtcc agtttcatgt caattttctt agcgactgct 3440461 tccatcactt ccacgtcaaa gcctgtcagc tttccgtttt ctttataagc aaatgggtaa 3440521 ctttgtcctg tcgcaccgac atgaagcaca ttgtcatcct ctttactgct gctgtttcca 3440581 ttgccgcaag ctgagagcac cgctaataat gcagcaacga ccagcactgt ccattttttc 3440641 atcttcattt gattttcccg ccttttctat ttttatagat catgtcgcaa ttgttttttc 3440701 atatagactg tgatatgccc ttttccaagg tcttgttcac ctgagcggac atatcctttt 3440761 cgttcgtaca tctcaatcag ccacggatgc ttatccgctg ttccgagtga gacaaacgga 3440821 acctttaacg tatcgcgaag gattgtttcc tccagccatt gaagcagctt tgttccgatt 3440881 ccttttttac cggtgtcggg gtccacagca aaccaccaga tatgcggaac gccatacggt 3440941 cccggctgtt ttccccaagg cattctcaag gtgatggtcg cgatgatccg cccgtcttct 3441001 tccatgacgt agcaagcatt ttcccgaata tttttcagca ccaaatccaa atccgcatga 3441061 gcagcagcaa aacgaatgcc gagctttcga atcggttcat aagcccgcaa tgtcagctcg 3441121 agaagctgtt cggcatcacg ttcaactgca aggcggtatc gtggcttcat ctagcgttcc 3441181 tccttacttt gcatagcggt ttaccggctt ttccaaaccg aagtgctctc gtaatgttgt 3441241 gccttcatat tcttttctga acacgccgcg ctcctgtaaa atcggaacca cttgatcaac 3441301 aaacacttca attccttctg gaagaagcgg aggcatgatg ttaaacccgt cacacgcttt 3441361 cgtatccacc cattcctgca tcttgtcggc gagctgctcc ggcgtgccga cgaagatatg 3441421 gtggcctctg gagcctgcaa cgtatttgta aagctctcgt atcgtcatat tgtcacgttc 3441481 agccatctcc tgaacaagct tgaagcggct cttcaccgca ttggaagctt cggcgtcaag 3441541 cttcggcagc ggcccatcaa gcggatatgc cgacaaatca attccgccta agtaattttg 3441601 gagaatttgc agaccgacag atgggataat cagatcttgg agctccttgt atttggcttg 3441661 cgctgcttct tctgtatcgg caatgattgg gaaaataccc ggcataatgg caattttttc 3441721 tggatcacgt ccgaattccg cagcctgttc tttaatggat tgataaaatt cttgagctga 3441781 ttccaggtgg ttttgtgctg tgaagatcac ttcggctgtt ttggcagcca gcgcttttcc 3441841 gtctcctgat gatcctgcct ggataatgac cggctggccc tgcggggttc ttgaaacgtt 3441901 tagaggtccg cgaaccgaga aatattctcc tttgtggttc agctcatgca ttttttcttt 3441961 gtcaaagaat tcacccgttt ctttattacg gataaaggcg tcctcttccc atgaatccca 3442021 aagccccttt acaatctcga caaattcctc tgcccgctga tagcgcaaat ggtgttcaag 3442081 gtgcttttca ccgctgaaat tcagcgctgt tgattcaata gatgaagtga cgacgttcca 3442141 tccggcacgg ccattggaca gatgatccaa tgacgcaaac tgtctggcaa tatggaatgg 3442201 ctcgctgtat gtagtggagg ctgttgctgt cagtccgatt tttgatgtga cctgcgccaa 3442261 agcagagagc agggtgaatg gctcaaacct tgttaataca tttggatgtg atttgctgtc 3442321 aattgaaagg ctgtccgcta aaaacagcat atccagcttg cctcgctccg ctgttttcgc 3442381 aagctcttta aaataatcca aattcatgct cgcatctgac ggcgcgtccg ggtgccgcca 3442441 agacgcaaca tgatggcctg tacctgctaa aaatacccct aatttgattt gtttcttttt 3442501 gcttgtcatg gcgatactcc ttttatcatg tttttaggct gaataatccg aaaaataaac 3442561 tcctatattc ctagtcgttt aatatgaata aatcaaaatg tacctttgtc ttggacgttt 3442621 gtcaatgagt taagattaat tttttctatt caagcgaaaa gacccttgcg tgaccatgag 3442681 ggaacggcat tgattcattc aactagtgca acctctatat cggcaagaaa actgagtcta 3442741 atgaagcaaa gactcagttt tcttccaata atttcatata agatttcgcc atttcctttg 3442801 ccttttcttc gcttttgcaa accgcctatc cattcagacg ccgtaacgat tgtataaaaa 3442861 aacagctgac tccagatatt caaaccggaa tcagctgatt gatgtgaatt aattaagctc 3442921 atgaatactc tcttctgctt tagcggaaaa cactttaggc tccaaacagt caaggtcttc 3442981 atgaaataaa tttacttttt ggatttgccg attgtcatag tggtggaaat agtagtttcc 3443041 agtttcgttg cacatcacgg aagtatattg cgtataatga atttcgtctt cttccgttat 3443101 cactgcgccc tttggtatcg tcatatttgc caaaatttga aaagcggctg ttacaccttt 3443161 cgtttcatcg gccgccggct ctagatgttc tttcaaataa acagctctga caaaccggga 3443221 aggcggtgta taatcccccg gcagaccaac agttcctaag ccttggccaa aagcagaaag 3443281 ggctaatccg cccatctctt tgctctctaa ttgcttcggt ctgattcctg tatattgctg 3443341 cagattggtt acatgccata taaagtcggg gctgttcgtc atgacaccag gttgattatc 3443401 atagactttg aggccgtctg ctcttggttc tatcgtcagg tttcggcccg tccggtctga 3443461 caatatccag tgaagcggta aaactgtatc caatagatct aattttttct ctacaatcgt 3443521 taaagatcga atcttttctt ttacgtcttc caaagactga cagactgaca gcacccatgt 3443581 cacaaactca tgcgggacaa tgtgaacggt atcttcccgt atcgtttttt cgtactccgc 3443641 atagcccgga aaataaagcg ccgcacaaga taaaccgctt tcattaatgc cgtcggcaaa 3443701 taatatattt ccaagttttc tccccatacc gataaacgcg tactgtgtct gatgggccct 3443761 tccgtcagct tcactgttcc agctgtaacg gcgcggatag agaatcacct ctgtccccag 3443821 ctgaaatgca aaatccattg ttcttgctaa tacatgttta cggtcagcag tttccaatgt 3443881 aagacttgtg cacatttgat cagtcccctt ttcaattcag attaatatca tacatattgt 3443941 gaacgaattg gttttatcag cataacgaaa gtcaaatcga ttcgtcaaag aattgacatt 3444001 acatcaaata aaacgaaaaa atccagcctt tagaaggctg gattttttat tatttagcca 3444061 aaacaagctc gtgaatcgca tgtgcaacgc catgttcatt attggagcgt gtttgaaagt 3444121 ttgctgcttc caatacttct gggatggcgt ttgccatggc aaccccgcag cccgcccatt 3444181 cgatcattgt caggtcgttc ccgttgtcgc ctatgcacat gacttccgcc tgttcaattc 3444241 caagcagctg agccagctgg cgtacagcat ttcctttgct ggcttccgag tgcagaattt 3444301 cataaaagaa aggcgcgctt ctgaccattg tatatttttc tctcacgtct tttggaatcg 3444361 atgtaatgac gcggcttaag ttctccggtt tatcaataaa catcactttc gggatgagga 3444421 tatcttttgg cacctcgtca atcttgcgga aatgaagcgg cacctgtgtc acataggatt 3444481 cgtatacggt aaattcgcta atatcccggt taggcgtata caaattagat gagtcaaaga 3444541 aatgcatcgg cgtcttcagc tctaagctca ggtcatataa tgaagtcaaa tcatcataac 3444601 cgagagacag ctctgagacc acttcatttg tatgcgtatt ttgaacaagt gctccattat 3444661 acgcaataac atagtcgcct tcttcaatta aattcagttc atctaaatat ctctgcacac 3444721 ccccgatagg ccggccggtg caaagcacaa ttttgacacc ttccgctttt gccgcgtgaa 3444781 gggcgtcgcg gacctcctct gttacttcat gatgatcatt taaaagtgtt ccatccatat 3444841 caattgcaat tagtttgtac atcctgcatc tccttcatgt cgttttcagg ctatagtccc 3444901 atcatatcgt tttttctttt tgatattcaa ccggaagaga tggttttctc cggattctgt 3444961 ttagacgccg cccttgtctt cggatacgca agcgcggttt ccgctttctt tctgccttga 3445021 cgccgttttc tgcttttttc tgtttcatca gcagaaagcc ggcagctaga aaaggaatgc 3445081 cggttatatt caagatggca agcttcacac ccgccgcgat gaaaaagaac ccccatgaag 3445141 atgatggatt ccgtctgatc atgacgtaag ccgccatttc cagaacgatc aggatggcat 3445201 gaagcactat gccataaatc agcaatacaa gggcaaaaaa caaaacataa ttcacgattg 3445261 cccctgagta catcatagcg cgcatcattt gtataaacga taaggactgc atggagccgc 3445321 tgatgacatt agggttatag atcgtatagt cactaaataa atgtttgact ttgagaaaag 3445381 cccataatat aaatatccat tgaatgatat gtaaaacaag ccccgctgcc accagtcttt 3445441 cagctttttg atttctcatc tttctcctcc ctgccggtct ttgattcgat tcttgtcatc 3445501 gtttttctct gtccattttg ctcccatatc aatgtcccgt tttctcctct tttcagcgtg 3445561 cttttgagcg gataataagg gccgaggtac tgaatctcga tagacccgtc agtgctttgg 3445621 gaaatcacct tgtatgccat aaaaggcagc tgtacctctc ctcttccttc catcacttcc 3445681 gtttccacaa cctcgtcttc ggtaaatgtg actgttgctg atttcacacc gtccgttggc 3445741 ccgggggcac gcccctcatc ccacgttccg taataaaacg gcgtctcttc tttttgctgc 3445801 tggcagcccg ataccatgat gcatacagca attaaaaaca aaatgccata tttgtttctc 3445861 aaggggatca ccattctttc ctcctttttt gggcgaatgc cgtgccactg tgccaatgac 3445921 tacataagtt ataaggaatt cacccacaag gagactgatc acatgaaccc ttatcaatat 3445981 tacagccctc agctgcctca gcaggaacct tactatagcc actatgagta caatccttat 3446041 ccgcagcagg atgtatacga tccataccaa atggacagac agccggcatt ggaaagaaga 3446101 atcgcagcac ttgaacggca aaatgaacag cagtcaagag aattaacccg tctgacaaac 3446161 gaagaccgcc gtcaaaatcg ggaaattgca cggattgccg aacaggtcaa tcagttaagc 3446221 caggctgttg aacgccatac acgccgccta aatcggctca atcagcgcct ccgtacagta 3446281 gaaaaccggc tgaatatccc atttactgca ggggaaggcg gtttctgagc gaaacaaaga 3446341 aaaaaagcgg aatacgattc tcccatctca gggtttcgtt ttccgcattt cttatatgtt 3446401 aaaacggaac atttacataa aaagggtttg tacccagtat acaatcttta ccgttttcat 3446461 tcaaagatag aggggctgag gaaaataatt gtagttcctc tttgacggaa tttcttttca 3446521 ttcaagttgc atgataatac cgactcacgt caatcgatac atggagggat cattcatgca 3446581 taatacacaa cacggcttgc agcagctgaa ccaatgccgc caaactgctc agcagctcat 3446641 tcagcaaaca cagcaaagca gccagcaata tcgccaaatg cttcatcagg aacagcaaaa 3446701 catccaaatg ctgcagcaga ttctaaacca cgaacaacaa gctgcacata ccattcagca 3446761 agcactgcac gggcatgaca tggcgattca aaagtgccag caggttgtca acatgtgcaa 3446821 ccaaatgcaa caggaactta ctggacaatc cagcgtcatg aatacgaatg tgtctacact 3446881 tccattcggc caaaacacga catttcagca gcaatcctac cagcagtaac atataaaaag 3446941 ctcaacacaa tgcgagtgtt gagctttttt tcttactgtt ctttgcgaat atgtatatcc 3447001 tgaatagact gtttcggtgc atgaaatctg ctctcggctt cacttcttgc ctcggcaaaa 3447061 gcccgcgcct ccacatgatc tttgtagaca tccagctgaa tcaaatacag cgggcgcact 3447121 ttaaatccat gaataatggt taccgcccat aacgggacca caataaaaac accgggcaga 3447181 tcgggcaaaa caaaaccaaa cgcaaaaatg aaaaaataaa tgatgccgta catgatccac 3447241 tttctatttc taaccttgat gccaataaat aaaaaggcaa aaaaactggt aatggcaaaa 3447301 ggcatgaaaa taaacagcat ccaccagcta tgcagccatt cccaagcggc acctcttttt 3447361 gtaattccca tatttttctc ctcctattta cctataataa tcgattaggc acaccgcgtc 3447421 acccataaac gggaaaaact ttctccctta aaaatagtga tagacggaga acaggtttct 3447481 tgctatatta ttaattgata atgataatca ttactaatct attgagatac atagtgggag 3447541 ggttcttgat gaaaaagaac atattgctcg tgggcatgct tgtgctgctt ctcatgtttg 3447601 tcagcgcttg cagcggcacg gcttctaaag ggagctcaag cgattctgct tccgaaaaaa 3447661 cagaaatgag aacatacaaa tcaccaaaag ggaacgtcaa cattcctgca catccgaaac 3447721 gcatcgtcac tgatttttat gccggtgaat tgctgtctgt cggggccaat gtggtcggct 3447781 caggctcatg gtcatttgat aatccgtttt taaaatcaaa gctgaaaaat gtgaaggatg 3447841 ttggtgatcc aataagcgtt gaaaaagtga tggagcttca gcctgactta attgttgtca 3447901 tgaatgaaga gaatgttgat aaattaaaga aaatcgctcc gactgttgtc ataccttata 3447961 acacagcgaa aaacgtagaa gacacagtca gcatgttcgg agatatcgcc ggagcgaaag 3448021 accaagcaaa atcctttatg gctgacttta acaaaaaagc ggaagcagct aagaagaaaa 3448081 ttgccggcgt catcgacaaa gatgcaacct tcggcattta tgaaaacaca gacaagggcg 3448141 aattctgggt gttcaatgac aatggcggac gcggcggcca agctgtatac aatgcacttg 3448201 ggttaaaagc gcctgaaaaa attgagcaag atgtcatcaa aaaaggagag atgaaacagc 3448261 tctctcaaga ggttattcct gagtatgccg cagattatat gttcattacg gattacaacc 3448321 cgaaaggcga aagcaaaaca ctcgacaagc tggagaattc ctccatttgg aaaaatcttg 3448381 acgctgttaa acataatcgc gtgtttatca atgactttga ctcgttctac ccgtacgacc 3448441 cgatttctgt cagcaaacag gtggatatca tcaccgacat gctgatcaaa cgggccgaag 3448501 aaaataaaaa ataaaaaaac ggcacagtca tgacgctgtg ccgtttttta tgattcactt 3448561 taattttgac tgtacggagt ccggcatatc ttcaaacttg acttcttccc aagtctcgac 3448621 atactttcct ttcgccttca ccttcaaata cgcgttcttc cgaagctctt tgccggcgaa 3448681 aaaggtcact tcttcttttt tcccggatgc attatatccg tctaatgtat attcagtacc 3448741 gcccggacta agatgtctgc catctcgatc aatctgaaca tagacatctt gctggtgaat 3448801 aaacggatta aatctgtctg taacatcgtt atgaaaaaag agaagcccgc atattacggc 3448861 agcagccgcc aagacggcca ggattgccat tgcttttttc atctttgcac tccccttact 3448921 tgttcatttt tttcaaatag cttgaccgca ccgcgaggaa gaatagaagc tgaaaaatga 3448981 aaaaccctcc gatggtgaga ctgagcggcc ccgctacatc ggaatatcct tccacagcca 3449041 atgttctcaa ggcaaacagt gtatgcatga cggcaatgac aaatggaaag aagaaaagaa 3449101 tcgccaattg tattgtcacg ctttgcgcca tttctcgctc actcaggccg attttggcca 3449161 gtgaacggta gcgctcccgg tcttcatcta aatcagtgaa cagcctgaaa tataagaaac 3449221 ttgctgccgc gacaaagaat acaattgcga taaacaggcc gataaataga ctcaggctcg 3449281 gcagctgcac cgtatcatag taagtccccg cttttgaagc aaaatcagaa tgcacgtcga 3449341 tataattgcc gtaaatctca ttttgcaagg attggctgat ctcaagactg tctttccaat 3449401 gatcatagct gtagccgtat aatgacgctt tatcaccgag tgatttcagc tgatcaaagg 3449461 tttgatcatt caccgcgatg atagcattca atgagatcag cggttttttg acttctttta 3449521 ccgacagttt ttgatcagac agctcccctt tttggttcag cagcttcagc tgatccggcg 3449581 cttcgttttt gaaattgcgg tcatacgttc ccgggaaata gacagcctcg tcttctttca 3449641 ggccgttcac tttgacatgg aagtattttg ccgcatccga ttcactgatc atgtaaacag 3449701 ggggaacagt ttctccttcc tgatagcgaa cataggaaac atctattttg tctttcgtat 3449761 acgtaaaacc gtgtgttttc agttcatggt caatatcttt caaatgagtc tgttcttttg 3449821 gattgttgct gtaagataaa tactccattt cataagcgga ctcttccgct ccgacggtcg 3449881 atttgtacat tgcgagcacg cctgtcgcag taaacgcaac cgcggaaata atgctgacaa 3449941 taaagaacag gcgggcgttg tcttttagac gatagacaag gtcagaaacc caaatgatgt 3450001 ttttcccgcg cagataaaag gttttccact tcttcagcgc gcgcagaatc catatgctgc 3450061 tttggctgaa aaagaaatat gttccgataa cggtgagcag taaaatgata aacggttcgg 3450121 ccccgtggac attgccttta agaaccatgc cgtacccgcc gcacagacag gcgatgccga 3450181 ataaggacag aagcacggac ggcttaggct ccggtttaac cttgccagtg ccctttatta 3450241 atttgataac cgtatttgat ctgacaaaaa ggatcgtaaa ctgcgataaa aagaaaaata 3450301 agagcagaaa tccgcaggcc gtaataccga gcgctttcca aggcatatac aaaggcagcg 3450361 cgtccatttc taaaatataa gcgccgaccg taaagaacgt ctttgaaaaa atgaatcctc 3450421 cgataatacc ggctgcaatt gacatgacgc cgatgatcat attttccgca gtaatgagct 3450481 ttctcagctg ccccggcgtg atgccctgca tgagcagaat gccgaattct ttatttctcg 3450541 atttcaaaaa tgcattaacc gaatacagaa caaataagaa agaaaaaaca aagatcatcc 3450601 attccgcggc ggttaagcct tttttggcga tgttattcag gtagccttcc tttaatgccg 3450661 gatgaaacag gaacatcgca aaggtaaaga aaatcaaaac ggaaaaggcg ctgcttaaaa 3450721 agaatgcaag ataggccctt ttgtttctcg tgacgttttt ataagcgaac tgaagaaagg 3450781 tcatttgcgt ttccccccag catagacagc acatcgagaa tttgttcata aaatacttgg 3450841 cggttttccc cgcggtaaat ctcattaaac agttcgccgt cttttataaa gatgacgcgg 3450901 cggcagtagc ttgccgaaac cggatcgtgg gtcaccatca aagccgtgac atgatcatcc 3450961 cgattcaggc tctgcaacgt ttccatgacg tcttttgtcg ctttggaatc aaggtttcca 3451021 gttggttcat cggccagaat gagtgacggc ttatgaatga ccgctcttgc gatggcggcc 3451081 cgctggcgct ggcctccgga tacttcaaac gtccgcttgt taagcaggtt ttcgataccg 3451141 agctttgccg cgatgccgtg cagtttttct tccattacag acggcgcttc tttttcaagc 3451201 gttaacggca gcatgatatt ttcaccgatc gtcagcgtat ccagaaggtt gaaatcctga 3451261 aacacaaatc cgagctgctt gcggcggaaa tgagcgagct ttgtccgctt caggcgatgc 3451321 gggttttctc cgttaatcag gatatcgcct gaatctggac ggtcaatcgt tgaaatgata 3451381 ttcaaaagcg ttgtttttcc ggacccggac ggccccatca ccgccgtgaa ctcgccttct 3451441 tctattgaaa atgaaatttg ctttaaggcc tgataggaca cttgtccttt ataggtttta 3451501 tttatatgtt tgacttcaag catattcgcc atgaaaatcc tccttatggt tttattcttg 3451561 ttgatctggg ctgctttcat gtagtgccgg gacgttcaac ataaaaatcc ccttgacata 3451621 aatccatgtt atcaagggga aacaaagcgg gctatgttgt tttcttaacg cagccttaca 3451681 tttttgtaag aaatgaaaat cgaactgatg tcccttcacc gggagacgag ctgatgtcca 3451741 ccgtatgatt gagcttatct gtaatttctt tgacgagatg gaggccgatt cccgtagatt 3451801 cttggaaacg ccgcccgttt tcacccgtgt aataagggtc aaacacccgc ttgatgtctt 3451861 gtgagggaat cccgacaccg taatctttga cttcaagcac cgtcctgtct tcatcgcaga 3451921 agacattcag ctcaagtctg tcactcttgc ccgctgaata cttgaccgca tttgtgacca 3451981 cttggccaat cgcaaatttg agccatttgg catcggtgta aatctgatga tcatcgcaaa 3452041 cgttcatttt cggataaacg cgatattgaa taaaaaatcg tttatagctt tgaataactg 3452101 attggagaag ctcggacagg gaaaccgctt cgattttaaa atcccgttca aacaggtcga 3452161 gccttgaaga ataaagaagc gtctccagcc cgaattcaat ctgccggact tcttttttga 3452221 tttgttcaaa aacgggctca tcctcttctt gaatgattaa attaatgacc gacagcggcg 3452281 tctttacttg gtgcacccat tgattcatat acgtcacccg cgcgtcaagc ttggcttcgg 3452341 tctcatggag cttctggtgc tgcagccgga tcagctccat ctgcttttca tacagctctg 3452401 aacagaacac tgaagaaccg agatacggga tatccgtccc ttcctgcccc gagctgagcc 3452461 aatgatacac gccgcggtct ttgtaccagc gataggcaag atagcccgcc aaaataagaa 3452521 gctgcacgcc caatatgtaa aacaagtgag aaaaagaatg aagacccgca aaccagtaat 3452581 aaaagaagac aaacagccct tgaaggagaa aaagcagaat cagcactgca tgagaccgga 3452641 gaaacagctt catgactgcg ccctcagctg gtagccttcg ccccgcaccg cttcaataga 3452701 aacaggcgca ttcagctccc gcagtttttt tctgagccgc gtgatataca cgttaagtgt 3452761 attatcatcg atgaatatgt cggtgtccca cgtcttttcc atgagacggt cccgactcgt 3452821 caccttttct ccccgctcaa gcagcacttc caaaagcttg ctttcttttt tagaaagctc 3452881 acttttttca tcctgaaaac gcagttcaaa ccgttccaca aagagctgaa cgccggcata 3452941 ttcaaccact ttctctccct gctttgcggc gtactccccg tacgccctcc ggatctggct 3453001 tttgattttc gcaagcacaa tatcataaga aaacggtttt tcgatataat cgtctccccc 3453061 attttcaatc gccatcacct gatccatttc cccgcttctg gcagaaataa agatgatcgg 3453121 gcttgtggag tgctggcgga tctgccggca ccaataatat ccgtcatatg ccggcaaatt 3453181 gatatcaagc agcaccacat cgggcttttc ccgcaaaaag acatcaagaa cagctgtaaa 3453241 atccgcggcg accactgttt gatatccgta tttttcaagg taattctgca atagtccgcg 3453301 aatgtcttca ctgtcttcca caatcatgat tttattcaaa ctgaaccact cccgtttctt 3453361 acactgctgc catcatcata atcgttttgg gcgtatggac gcaacaccgc acaaaaaaac 3453421 cgccatctcg gcggtttctg gtctctttag ccgacctgct gcttagctgc tttaccggct 3453481 gatccgaact ctctcatttt gcttcgcact gtctcttcca cggcttcaat gccgggtgtc 3453541 aaatagccgc gcggttcgta cagatcgctg ttttcctgaa acatgcggcg tgtttcgtct 3453601 gtccacgcta ccatacattc cgtattgata ttgatcttcg cgtggccgag cgtgatggct 3453661 tttttgatct gatcctgcgg aatcccggat gccccgtgaa gaacgagggg aatatcagtc 3453721 atgcgggaga tagcctccat ttccttaaat ccgagattcg gctcaccctg atatttgccg 3453781 tgtacagagc cgagggcggc ggccagcgcg tcgatattgg tttctttaac gatccgctca 3453841 cattccgtga tatccgcata gcggaccccg ccgaccagtc cgtcttccat tccgccgacc 3453901 gtgccgactt cggcttctac tgacacgccg tgttttgcgg cataatcggt gacttctttt 3453961 gtcatcgcga tattctcgtc aatcggctga tgggagccgt caatcatcac tgagctgaat 3454021 ccggcatcaa tggcctgtct gcagcgttcc gcactgctgc cgtgatcgag atgaagcacg 3454081 accggaacgg taatcgccat gtcctctatt aacgcgccga ccatggcggc aatcgtttta 3454141 aatccgccta aatagtcgac caggcgatcg gaagccgcgg cgatgaccgg tgattgctcc 3454201 ttttgcgccg cctgcaaaat cgccttcgtc cattgcaggc cgttgatatt aaactggcca 3454261 attgcatatt gctcccgctt tgcatcttca agaagctctt tcatcgatac aaaagccata 3454321 ttcacccctc ctttatccat tacatgctga agtattttga tacgacatcc actgttgttt 3454381 ttttcgctgt ttgaatggct tcctcagcag tcagcttata gtattcaggc cggaagagct 3454441 caaccgaaac aacatcagag aagccgattt ccttcagtgc tgataagtgg gcatctaagt 3454501 caattgcccc ttgtcccggc catacacgat cctcatctgt taaaaagccg attgggaaat 3454561 cttctgtatc atcaatatga tagatgaaga ttttctttcc gtccgcctgc tttaagctct 3454621 caatatttga acccattgca tggaagtgaa aactgtcaag gacaagcccg acattgtcac 3454681 ggttaactgt gtttacaatc tcatacgcct gttcaaacgt attgaccgta cattgcggat 3454741 ggccgacaaa ctcaagcgcg atttttacgc cgtacggctc cgcgatatct gacagctcag 3454801 tcagcacgtc tacactgctc tttttgatct cttcttttac aatcttctgc tctgtcacaa 3454861 gcggaacggc caccacatat ttcacaccga gggttttgca tgtttccatc atgcctttaa 3454921 attcagtgat gatctcgttg tgaccctttt catcacggtt gttgaagaaa acgagtgcgt 3454981 ttaaggcaag cggtttgatg tggtgggttt gaaaatattc cgcaaggtca tccaatgaat 3455041 gatcttttaa gtactccggc agcttatcca tagtacggat ttcaatataa tcatagccat 3455101 gcttttcgca tagttctaaa tccagtttaa ggtttgagtt ttccaatgtt gtcgcttcat 3455161 taaaacaaag tttcatgcca gactccccca tctgcgtttt agatatgaag ggagttcggc 3455221 aggaaggctg tcgccatatc ccgccgaact ccatgctcag cttatgccag acctaattct 3455281 tctttcattt tcttaagcat aaatcggctt gattcatccg ctctttcatc gacccaagca 3455341 aatacggcat tcgtcgcaat tccgtcgaac ttcatctctc tcagttttct gaaaatcgta 3455401 tcaaaatcaa cctcgccttg gccaatgtcc aaatgctggt gaaccgttac tttcgcgtca 3455461 ggcggattga cgatgtagcg aaggccatga gccgctttat gattataggt atctgcaaat 3455521 aaaacatgtg tgaggcggtc gccggcttcg tcaaacatgg tctcgatgtc gcctttgccg 3455581 tcatcataga agaacgtatg cgcagtcgag tagacaagat tgatccaatc cttgtcaagc 3455641 gcgcggatca tatccatcgc acctttgtgc gtttcgataa aatcatatgg atgggcttga 3455701 agattgagtt taatgccttc tttttcaaag actggcagaa gctcatccat ggatttgata 3455761 aatttttctt cacttgttaa aggatcatat tttgaaccgc tgaattcgct gttcatcaaa 3455821 tccacttcaa gttcaaccgc aatttcgatt gcccgtttcc agttgcgcac tgctgcctgg 3455881 cggcggtctt catcgggtcc cgcccagtgg taaagaggaa gaagcgatga aagcttaaca 3455941 cctgtatctc ttaaaaggcg ctttaattgt ttgatctttg ctgaatcgac tttcggatat 3456001 ttataaaacg ggcaaaaatc ctcgcgcggc gataattcga tatattcata gccgagctct 3456061 gccgttttat agaccatttc ctctaaagtt aaatcatcac gatacatgga tggatccaat 3456121 gctaacttca tattttcact cctctgtttt ttagttttga actgttgtaa aagattgata 3456181 gaattccggt ttttccttca attcaacctt ttctttttgt ccagattcct gggcttttac 3456241 acacgcgtca gtcgtgacag cagcaatata gccgtcccat gccgtcggtc cgctgacctc 3456301 gcctttcttt tgaatcgaat caataaagtc ttggatttcc acatcatacg cagcgacaaa 3456361 gcgtctctgc caatccatca aaatatcagt gctgaatctg ccttcttttc tcaagctgat 3456421 gcttgatggc tcgggaagct tgatgatgcc gtcttctccg acgatttcac attgaatgtc 3456481 atagccgtat ttacagttca catagatttc agcattgatg acgataccgc cttttgtttc 3456541 aatcacgacg atttgcggat cttttaaatg tggaagcgcg ttttttgatt ttttcggata 3456601 gatgacttga acggactcgt agtcatcatt gacgagccag tggagcacgt caatttcatg 3456661 aacaagcgtg tcgactacag ccatatccgt tgtatagtta tctcctacag tcgggttgcg 3456721 gtgcgcgcag tgaatcataa gaggctcgcc gatgacatga ttatcgagcg cttctttcag 3456781 ctgtacgtaa ccgctgtcat aacggcgcat gaagccgact tgaacaaggc gtttgcccac 3456841 tttgatttct tcttcgacaa tgcgcatgca tccttcagcc gttgtcgcga gcggtttttc 3456901 acagaacaca tatttctggg ctttaatcgc tttcagcacg cttgactcat gcgcaggccc 3456961 ccagcttgtc actaaaacag cgtctacatt ttcgtctgca agcaagctgt catcattcgg 3457021 ataaaccgtc gcgtttaatt ggtattgctc aacgaccttt tgtgcagctt cttgattaac 3457081 atccgttaca gctacaattt ccgcgcctga cagcttgttc gtgatacggt taatatgttc 3457141 ttttccgatt gctccagttc caattacgcc aatacgtaaa ctcattgaca gccactcctt 3457201 ctgttggtta catgattttg ctttctgttc ctttctttac ttggctctga ggagacccgt 3457261 agagttcctc ttgaatttgt tcaagcgact tgccagacgt attcggcgca aagagcagcc 3457321 cgatgatcat actggccgtc acacatccga gaagaattgc agccatcgtt ccaatgccga 3457381 aattggtgat aatcattggg acaaacagac tccaaatccc tattgaaata cggacaagga 3457441 aaaacatcag tccttgtgcg gaagcacgat attgcgtagg aaagatttcg ctggcccata 3457501 actgatagtt cgcttgctgc ccggctccgt tattgatgcc gatcacgaca ataaacagga 3457561 gcagaatcgg caggccttca actggcagca gaaacagtgt ccacccgatc accgccatga 3457621 aagcggcgat tccaaatacg gtttttctat atttgtcggc aaagggcatg aagatcaagg 3457681 cgacccccaa tcctgtgaag ataaacagcc ccatttgcaa aaggttggcc atgttggcag 3457741 atacaccgcc gacctgctga taaatgtatg gcataaagaa gcccatgacc ccggcggcta 3457801 ggttccaaac caagtacaca cccatcaaaa acaggatgct ttttagatac ataggcttga 3457861 gcaaatcaaa atacgatgtc ttattcaata cagccggctt ctctgcctga gcttcctccg 3457921 gctgattttt tgtctgccag gcgtctgatt ccggaagcct gattctcagg atgtacgtaa 3457981 tcagcgcaat cacaagcaga tgggcaaata cgattttatt ccccaagagt cccaagtcac 3458041 cggccagtac ggagaggagc agtacaacga cagcgcccgc ggcccaagcg acttgtgcta 3458101 cgccgcaatg cctggcccga ttcttctttg gcgcattttc cgcaataatg gtccatgacg 3458161 cggttatgtc agcccctact gataaaccga taatgatgta accgcttaac aacatgggga 3458221 aattaacccc gaacaaaacc aaacaaatcc ctagtgcata aaccagcata ctattggtat 3458281 aaacagcctt ccgtccgact ttatcagcca gaaacccgcc aagcagcgcg ccgacagcgg 3458341 cagaaatcgc atttgcgctc aacgcgccga gcagcccgat ttgcgtatcg gatagcttaa 3458401 ggtaactgac ccataatgat aaaccggcgg agcctgccac aattgaaccg gcatcaatat 3458461 agttggccaa tgctgccgcg attgtccgtt tattgaaggc tgaatctcca ttggtattgc 3458521 ccatatgttc attccccatt aagccagatc caacaactgc tgatcaatat agtttctcgc 3458581 aatcaatgca tactccagcg ggtttgcaac atcggggtct tgttcagctt caatgacaat 3458641 ccatccggaa taactgtgct tcaacagcag ctgatatact tctctaaagt caatgcagcc 3458701 gtcaccggga accgtaaaca tgccttttaa aaatgattgc cggaacgatt gtccttcgag 3458761 cctgcattgt tccatgacat tcaggcgggc atccttaaag tgcacatgct taatgcggcc 3458821 gatatgcttc tcaagcatcc ccatgtaatc gccgtcagaa atatacgcat ggcctgtatc 3458881 atagaggagg tgtacatgcg cagggtctgt tcctgccatc aggcggtcca cttcttccgc 3458941 tgtttggaca ccagtgccga gatgatgatg atagacaagc ttcaagccat gctgagcggc 3459001 aatttcgcca aggtgattca gcccttcgca aagccgctcc cattcatcat ccgtaaagtg 3459061 cggcttctct gtgaacacat ttttctccaa gctttgcacg ctgtacgttt gttcagagac 3459121 aactgcgaca tccgcgttta cttgctgcaa atactcacaa tgcagggtaa atgtctttgc 3459181 cgcttcacca agtccgtcac gcaaaataaa actgctgaac cattttcctg caatgcgtaa 3459241 gttccgaagc ttcagctctt tgttcaggat ggcaggttcg gggaaaaagc ccccgacctc 3459301 cgtgccttga aaacgtgcga caacgatatc acttaacaaa tgctgaagtg tatttcccgc 3459361 tccaatttca ggcatgtcat cattccgcca cccaatggga gcgattcccc acaggatttc 3459421 atttttgccc atctatggtg cctcccctct aatactgctt cgcagattcc agctttttct 3459481 cttttgcttc gtatgctttc tgaacgcttt cttgttcaga tacctctgcc accccgacat 3459541 gccaccagct gtcatagccg tccgtcattg ttttaggcag caccttcatt tcaattaatg 3459601 ttgatacatc ctgtttcttc gcatcctcta acgcagcttt taattcttct actgtgtttg 3459661 cacggtaggt tttcgcgccg tatccctcag cgactttcgc gtaatcgaca ttcaggattt 3459721 ggttgtcatc tgtgcggaac tcgcaatagt agctgccgct gccgtgatcc atttgcaggt 3459781 tgttgatgca tccgaatcct gagttgtcaa agagcagcac attgattttc ttgttgtact 3459841 gaatcgccgt gatcagttca gaatgaagca tcaggaagct gccgtctccg acgattgaat 3459901 acacttctct gtcagggtgg gccagtttaa gaccgagtgt cccggacact tcatagccca 3459961 tgcaagaata tccatactcc aggtgatacg tattcggaac attagaatgc cacagacgct 3460021 gcaaatctcc tgggagtgag cctgctgaac agatgatgac gctgtcttca ggaatcgtct 3460081 cgttgattgt cagcaatgcc gttgtttgcg gaagctccgt attcaacgcg tcagcatatt 3460141 cattcaggac ctcttgagaa aagtgatttt tgatttccgg atcaaatgct tcccgcttaa 3460201 acgtcacttt gctgagacgc tcgcgttcag ctagccattc gtccttcagc tcccggatcg 3460261 ttgtgccgaa ctcgctctca tagccttcaa gcaagccgtg cagtttgcca agcgtcactt 3460321 tcgcatccgc caccacttgg aatgcatcaa gtttatacgc ctgcattcgg ctgacgttaa 3460381 tgttcaaaaa cttcgcttta tcaaaatcaa aagcggtctt agaggatgtc gcaaaatctg 3460441 tataccttgt gccgatgccg ataatcaaat cagcttggcg ggccgctttg tttgccgcaa 3460501 gtgtacctgt gatgcccatt ccgccaaggt tgttcgcaaa atctgcctca acggtagact 3460561 ttcctgcctg cgtttcaact aacggaatgt tataggcttc agaaatggca accaattcat 3460621 cgcgcgcacc ggaatatttt gcgcctccgc cgacgagaat cacaggtttt ttgctggatt 3460681 taatcagctc cgccgcacct tgaagctcgc gctcgctcgg ctgcatgcga tcaatatagt 3460741 gaacccgttt gacgaagaaa ctttcatcaa aatcgtatgc ttccccttca acatcctgag 3460801 aaatacaaat cgttgccgga cctgcttttg ccggatcagt catgacttca aacgcgcgca 3460861 gcaaactgct catcagctgc tcagggcgcg taatgcggtc ccagtatctc gatacaggct 3460921 tcaatgcatc gtttgtcgta atcgccgcac tgtattcttg ctccatttgc tgcagtacag 3460981 ggtctggctg tcttgtcgca aatgtgtctg ccggaatcaa gagaactggg atattatttg 3461041 ccaatgcagt gccggctgcc gccaccaagt tagccgctcc aggtccgacg gatgtagaca 3461101 ccgcatatat ttttcttctc agcatttgct tgctgtacgc catggccgca tgcgccattc 3461161 cttgttcatt tttcccttga tagactttca aatggcctgc atcctgctca agcgcctgcc 3461221 cgatccctaa tacgtttcca tgaccgaaaa tcgtgaagat cccttcgaca aaaggctctt 3461281 cctttccatc tacatggatg tactgctggt ttaagaattt aatcagcgcc tgcgcagttg 3461341 ttaagcgaat tttcttaccc acaaacgatc ccacctttac tcgatctttt tcaattatga 3461401 ctgtgcttca ataagctgtt cgatttcttc cgcagtcggc atcgcttctg acgaactgtg 3461461 cttgctcacc acaatggagg ctgaagcact gccgtatttc aatgccgttt caatgtcttt 3461521 tccgctgaca aggccataga taaaggctga cgcataggag tcaccggccc caaaggtttt 3461581 cagcactttt gtcttgtacg cttgagcgcg gaatacctcg ccggatttgc tgtatgcgta 3461641 agagccttcg acgccgtgtt tgatgacaac gaggtcggct gaatggccaa ataaatgatt 3461701 gacggattct tcattgcttc cgcctgtgcg gttttccatc acatcaaatt catcgcgtgt 3461761 gccgatgacg atatcagact gctcggcaac caaagaataa taaacggctg tttcatctga 3461821 tgactgccac gtatatggcc ggtaatccag ttcgaatacc accttaacct gatgcttttt 3461881 cgcgtattga acagctttta acaccgcttc ccgtgacggg cttttggcga gcgctgtccc 3461941 ggagacaagc agcattttcg catttgcgat atagtcctca cttacctctg aaggctcaag 3462001 ataaagatcc gccacatcat cgcgatacat taagatgctg cattcttcag ggctgaggat 3462061 ttctgtaaat gcaaggcctg ctttgtgtcc atcttgatca acaatcatct gtgtagtatc 3462121 cacgccggtc tttctcatat aggactctat gaatcttcca tgctggtcat ccggaatttt 3462181 gccgatgaag cccgctttta agccaagctt cgcgctgccg atcgcgatat tcgcaggtga 3462241 accgccgaca tatttcgaaa atgtcatcgt ttcttccatt gggcggttgt attcgactgc 3462301 gttcagatca atacatgccc ggccgatggc aacaatatca aaagccttct cttcattgaa 3462361 tgtatacttc atcgtaaaca gccactcctc acttgttagc gttctaaaat ccattcatgc 3462421 gccgggtcgt tataaaactt ccattttcgc gtcggccctg ccatgacatt taaatagtag 3462481 gatgtgtatc cgtccggaac gcctaccggg tggtatcccg caggaacgat gacaacgttt 3462541 tcatttccca cagtcattgt ctcgtcaata gaacggtcat ctgtgtatac gcgctgaaac 3462601 acaaagccct gtcccgggtc taactcatgg tagtacgttt cttctaagaa agattcttcc 3462661 ggcaagttgt cttggtcatg tttgtgaggc gggtagctgg accagttgcc gctgtctgta 3462721 tagacttcaa ctactaatag actgttagct gaagggtctg aatccggaag aatgttatga 3462781 acagtacgtt tgtttgaaaa ttgcccgcga tgctcaattc cgttgtcttc cgctttgatc 3462841 agctttgtcg gaagctgctt ttccgatgga gaatagcaaa gcgccactct tgcgtcgctg 3462901 accgctgtga tctcaaatgc acggtcattt gaaatataga cgctgtctgt cggttttcgt 3462961 tcaaatacgc tttcgcgcgt gccgatattc tcaaaagtcg actcatgatc tgtcactgta 3463021 attttccccg ttaccgccac aatacagatt tcttgttttt tcaattcttc tgtatagctt 3463081 gaacctgatg caagatctaa cactttaaac tctacataag tgagatcaga gttggatgtc 3463141 gttacttcgt gcacgagttt gaccccatta gacacttcat gcgactgcgg cttacgcaac 3463201 aaataactca tagagaagcc ctcctctttc tattggcaga atgagtccga acagcgcaca 3463261 tggacgccgt tcggctgttc gtcgtttagt tgaaatcagg tgccggatat cttgccgtca 3463321 ccactttttt acgtgtatag aagtcgacgc tgtcttttcc gttcgcatgc agcgttccaa 3463381 agaatgaaga tttccagcct gagaatggga agaacgccat tggagccggc acaccaaggt 3463441 tgatgcctag cattcccgca tcaatgtttt cacggaagta gcggattgcg tttgagttgg 3463501 atgtgaacaa gcaggcgccg ttcgcaaact cagacttatt ggcgatttca atcgcttctt 3463561 tcaggttttt cacacggatg acagataaga ccggagcgaa aatttcatct ttccagatcg 3463621 tcatttctgt tgtgacattg tcaaagatcg tcgggccgac aaagtagccg tcgtcagaca 3463681 cattttcacg tccgtcacat acgagtctgg caccttcttc aagacctttt tcgatatagc 3463741 tgagcgtgcg cttcttgttg tcttcgcgaa tcaccggtcc taagaacacg ccgtcatcaa 3463801 ggccgttacc gattttaatg tccgccactt tttcctgcag cttcgccata aattcatcgg 3463861 cgattccttc ttcaactgtc acaaccgcac aagccatgca gcgttcaccg gcagaaccga 3463921 aggcagctcc aacgatgttt gtaaccgtgt cttcaagatt cgcatcgttc aagacaatcg 3463981 tatggttttt cgcgccagtc agagattgaa cgcgttttaa gttttcgctt ccttttttgt 3464041 agacgtattc gcctactggc ttggagccta caaatgaaat cgctttaatt tcgggatgct 3464101 cgaggatgcc gttcacaacg tcatgcgcac cgtatacgac gttgaacacc cctttcggaa 3464161 ggcccgcttt ttcaaaaagc tcaaccaatt tctctgttaa cagcggagtc cgctcagatg 3464221 gctttaaaat aaatgtgttg ccgagcgcga tcgccatcgg gaacatccag caaggaacca 3464281 tcatcgggaa gttgaatggc gcgattccgc cgacaactcc gattgggtaa cggtagttcg 3464341 ccgcttcaac gtccgttgcg atggaagcaa gtgagtcacc catcatcagg gaaggtgctc 3464401 cagcggcgaa ctctacgttt tcaatcccgc gtcccacttc acctaaagct tctttcgtgt 3464461 tttttccgtt ttcaatggta attagatgag caagttcttc tttatgctga gacagcagct 3464521 gctggaagtt aaatagaatt ctggcgcggc gaggaaccgc cacctttgac catgttttaa 3464581 atgcttcagc cgctgtttgc gctgcgtaat caatatcctc ttttgtagaa atcggcactt 3464641 ggcatagcac ttctttcgtc gccggattga cgacatcttc atattgatct gttttgcttt 3464701 caacccattc accgttgatg tagtttttta attttctgat ttctgccatt cttattgcct 3464761 ccttcattag taaacacata cacttgtatg gatggttccg gatagattca tatcaatatc 3464821 cacttttcag caagccaaga attaaacgct ttcaaaaaca ccaaaaaaat aaatggcgga 3464881 tgcatattta catacaagca accatttcat gcacaacagg ttactttttg gtcatttctt 3464941 ggttatattc taatcgcata atacccataa gtcaatcata aacactacat tttttcatta 3465001 tttttattat attaatcttt taatcaagta agagaagtaa gagaaggccg tccaatcttg 3465061 caaaagatat acaccgatgt tatcattttt aagcaactat tgattaactt ttggttttta 3465121 ttatatattt atgttacgta aagattcaag aaggagtttt ttatatgaaa ctgatgcgga 3465181 ttcaggaaat ggaggagtac attttatcgc atggcactgt ttccttagat gagctgtgcc 3465241 aggtgttcaa tgtctccaaa aacacagtca gacgtgatat caacaagcta acagaaaagg 3465301 gtgcgattga aaaagtatac ggcggcgtaa catctattga aaaaaccgca ttagttcctt 3465361 ttgaaaatcg caccattcag caccaggatg aaaaaacaaa aatcgcccat tatgcttccc 3465421 gatttattga agatcacgat ttggtcttca ttgattcagg aacgacgaca aagtctattc 3465481 ttgatacgct tgatccagcc aaaaatgtca ccatcttaac caacagttta gacattatca 3465541 atgcggcgtc agctttgaag aatatcaact taatcattat cggaaacaac tataagagaa 3465601 aaacccgctc ctttgtcggc atggacgacc cggctatgct tgataagtac aatatcaaca 3465661 aagcctttat gtccgctacc ggaacgacgc tgactcacgg attgaccaat tcggatctgc 3465721 tggagtatga aattaaaaag aggatttcag aaaaagcaaa agaagtgtat ctattggctg 3465781 accattctaa attcggaaaa tcaacgcttc tgacgtatgc accgtttgac aggctgcatt 3465841 gcattgtgac ctctcagcca ttagacgacg agtacacgca gtactgcaat gagcatcaaa 3465901 tcggcattca tctggcctaa cgtttacaat agtgttgaga gtctatcatc cattttattc 3465961 taggaggcag atcatgaaaa aagcgaagct cggaaaatca gacttgcagg tattccctat 3466021 cggattagga acaaatgctg tcggaggaca taacctctac ccgaacctaa atgaagaaac 3466081 cggaaaagaa ttggtgcgcg aggcgatccg taatggcgtg acaatgttag acaccgctta 3466141 catttacggg atcggccgtt ccgaagaatt aattggtgaa gtgctgcgtg aattcaaccg 3466201 tgaagatgtt gtcatcgcga caaaagccgc tcacagaaaa caaggcaatg actttgtctt 3466261 tgataattca ccagattttc ttaaaaaatc agttgatgaa agcctgaagc gcttgaatac 3466321 cgattatatt gatttgttct acattcactt ccctgacgaa catacgccta aggatgaagc 3466381 cgttaacgcg ctgaatgaga tgaagaaagc cggaaaaatc cgttccatcg gtgtatccaa 3466441 cttctcttta gagcaattga aagaagcaaa caaagacggt ttggtagatg tattgcaagg 3466501 cgaatacaac ctgttaaacc gtgaagcgga aaaaacattc ttcccgtata cgaaggagca 3466561 taatatttca tttatccctt acttccctct cgtatcaggt ttattggcag gaaagtatac 3466621 agaagataca acgttcccag aaggcgacct gcgaaacgaa caggaacact tcaagggtga 3466681 gcgtttcaaa gaaaatatca gaaaggtcaa caagcttgcg ccgattgccg aaaaacacaa 3466741 cgtggatatc cctcacatcg tattggcctg gtatttagca agaccggaaa ttgatatttt 3466801 aatcccagga gcaaaacgtg ccgatcagct gattgataac atcaaaacag ctgacgtgac 3466861 gctttctcaa gaggatattt catttattga taagctgttc gcataagaag aaaacagcct 3466921 tctccaatgg agaaggctgt ttttttgtgc gataaattcc taaataactg attttgaagc 3466981 aaaaccttac aaaatgagcc ataaatccga taaaataaag gtagtttatc tcagaaagaa 3467041 agtgattgag aaagcaaaag tatgaaacgt tcatatcatc tagctcatat gaaataaagc 3467101 tgacccagct tcttttattt gctggtcaga atagcggacc gtttcgatgg tctatggagg 3467161 aaacagaatg aaacttaaat atgtaaaagc cttagttgca gtaaccgttg ctttaggtgt 3467221 actgctgcca tcaacgattt ctcatgcaaa gagctttagc ggccgctcat catctagtta 3467281 cagcagccga agttcaagct catcatacag cggaagctat aaatcaagcc cgaaatcaag 3467341 ctacagctca ggatcaagct cttctagcaa aaaatccaag acgtctgacg attcatcatc 3467401 atcgatttcg cttaaaaaga agccttcgga aaaggcaagt tcatcaagct ctaaaaaatc 3467461 gtcaggcacc ttttccggcg ctacatcaaa agtaaccgga aagacataca gcggaaaaac 3467521 gtctaaagcc tatgttggcg gacgttatgt ttcagtcaat cattactatc acgcaggttt 3467581 cgcgccatca ggatggtttg gatattatag cggatttaca atgggtatgt tcatgatcag 3467641 catgatgcac ccatggggtt acacctatca tccagtcgga ggccccggtt atgtttctta 3467701 tggcgcttca cccattgcct ggatcgttga tatcatcgct ttgattatta ttttaatcat 3467761 tgtcatcgca ttgattcgcg catttaaagc accgaagacg tacagaagga gattttaggc 3467821 aatgagatta atattaaatg agcaagaaat tgtagacgga atttgcgtgt atatttccaa 3467881 tgaagaagat atctaccctg aagacgttga agtaaaagaa ctatcgtaca acaagcgtac 3467941 agggttcttc gctgaagcta catttggcct gcaccacaag cagcttatgt cagatgacat 3468001 ttcagaaggc attattcagt tcttagagga ataccacaac ttcaatccgg acgttaccgt 3468061 cgttgaattg caatttgata agaaaaaagg cttctccgcc ttggtttttg tcaacgaagc 3468121 agaagaataa aaatgtctta atcaaacctt actccgcgcg ggtaaggttt ttttaatggt 3468181 ttctctgagc ataaagttat ttcgtttttc ctaaactcag cggatctgtg atcatctctt 3468241 ttggctataa agtttccgtt ttttcaaaac aaatgtttca aatgagatag gaaatgggta 3468301 ctaatctatt aactttgtta catattttta gatactcatt ggctcaacaa ctgaggagga 3468361 gacatttgtg aagaaagaca caaggaaata tatgatctac tttttcggcg ctttaggggg 3468421 actgctatat ggttacgata caggtgttat ctccggagca ctcctgttta tcaataacga 3468481 tattccttta acgacattga cagaaggatt ggttgtcagc atgctgctcc ttggcgcgat 3468541 tttcggttct gccttgagcg gcacatgctc agaccgctgg ggcaggagaa aggttgtatt 3468601 tgtcctttcc atcattttta ttatcggtgc gctcgcttgc gcattttctc aaacaatcgg 3468661 catgctgatt gcatctaggg tgatactcgg gttggccgtc ggcggttcaa cggcacttgt 3468721 gcccgtgtat ctttccgaaa tggcaccgac gaaaattcgc gggacactcg gcacaatgaa 3468781 caacttaatg attgtcaccg ggattttgct cgcctatatc gttaactacc tgttcacacc 3468841 gtttgaagcg tggcgctgga tggtcggtct ggctgcagtg cctgccgtgc ttctattaat 3468901 cggcatcgcc ttcatgccgg aatcgccaag atggctcgtg aagcgcggca gcgaagaaga 3468961 agcgagacgc atcatgaaca tcactcatga ccccaaagac atcgaaatgg aattggcaga 3469021 gatgaagcaa ggggaagcgg agaaaaaaga aacgacactt ggcgtgctga aagccaagtg 3469081 gattcgccct atgcttctga ttggcgtcgg ccttgccatt ttccagcagg cagtcggcat 3469141 taacacggtc atctactacg cgccaaccat ttttacgaag gccggtcttg gcacatcagc 3469201 ttcggcgctc ggcacaatgg gaatcggcat cctcaacgtc atcatgtgta tcactgccat 3469261 gatcttaatt gaccgtgtcg gccgcaaaaa acttctgatc tggggaagtg tcggcatcac 3469321 actgagcctt gctgctttat caggcgtgct cctgacactg gggctttccg catcaacagc 3469381 gtggatgaca gtagtctttc tcggtgtcta tatcgtcttt taccaggcga catggggtcc 3469441 ggtagtgtgg gtgctcatgc ctgagctctt cccgtccaaa gcacgcggag ccgcgacagg 3469501 gttcacgact ttggtgttat cggcggctaa cctgatcgtg tcgcttgtct tcccgctgat 3469561 gctaagcgcg atgggcatcg catgggtctt tatggttttc tcagtcattt gtcttctctc 3469621 atttttcttc gcgttctaca tggtaccgga aaccaaaggg aaaagcttgg aggaaattga 3469681 agcaagcctg aaaaaacggt ttaaaaagaa gaaaagcacc caaaaccaag tgctgaatga 3469741 gcgtacatta taaaaaaagg aatcgtctcc ttatgagacg attccttttt ctgtttacac 3469801 catgaccttg caaatattgt tcgtaaattc cacagggtcc tgaatcggca ggccttcgat 3469861 gaggagcgcc tgattgtaca gaaggtttgt gtacaggctc agcttctctt tatcttgttc 3469921 aaacgcgtcc tgcagtgttt ggaatacctc gtgatttggg ttgatttcca gcactttttc 3469981 cgccttcaca ttttggctgt caggcatcgc atttaagatt ttttccatct caattgtcac 3470041 ttcgccgtca gcagcaaggc agactggatg tgatttaagc cgttttgaga ttctgacgtt 3470101 tttcactttg tctgacagaa tgtttttcat ttcctcaaac agatccttat acttgctttc 3470161 ctcttcctcg gactgctttt gatcctcatc cgtgtctatg ccaaggtctc cgcttgatac 3470221 ggacttgaat tctttttcct gataagaagc cagcatttta attgcaaact catcgatgtc 3470281 ctcagtaaag tagaggattt catagccttt gtccgccacc atttccgttt gcggcagttt 3470341 ctcaatgcgg tcgtaagaat caccggtcgc gtaataaatg aatttctgct cctctggcat 3470401 tctggaaaca tactcgtcta agctgaccag ttttttctct tttgaagagt agaataagag 3470461 gagatccttc aattgatcct tattcgcgcc aaaatcattg tacacgccga atttcagctg 3470521 tctgccgaac gacttgtaga acgtctcgta tttctcgcgg tcttttttca acaggctttg 3470581 cagctcgctt ttgattttct tgctgatgtt tttcgcgatc agcttcagct ggcggtcatg 3470641 ctgcagcatt tctctggaaa tattcagcga cagatcctca gaatcgacca tgcccttcac 3470701 aaagctgaag tggtccggta gcaggtctgc gcacttattc atgatcagca cgccattgga 3470761 atacagctcc aagcctttct catattcctt ggaatagtag tcaaacggca tgttttcagg 3470821 gacgaataga atcgcgttgt agcgaaccgc tccatccacg ctgatatgaa cgtgtgtcag 3470881 cggtttatca aacccgtaat gcttttcagc atagaatttt tcataatcct catctgtcag 3470941 ctcgcttttg ttttttctcc agatcggcac catgctgttg accgtctgct cttcctgcac 3471001 ctcttcaaat tcattttcgc tgccttcctt cggcttatta atggttgtat ccattttgat 3471061 cgggtagcga atgaagtcgg agtacttctt gatgatcgct tttaaacgat attcctctaa 3471121 aaactcgtca tagctgtcat cttctgtgtt ctctttgatt ttcaggataa tgtctgtacc 3471181 gacagaatcc ttttcacacg gctcaatcgt atagccgtct gcacccgcag actcccattt 3471241 ataagcctct tcgctgccaa gcgctttact gatgactgtc acgacatcgg caaccataaa 3471301 tgccgcgtaa aaaccgacac cgaactgccc gataatgtca tgtccgtctt tcagctcgtt 3471361 ttccttttta aacgcgaggg aaccgctttt tgcaattgtt ccaagatgct gttcaagctc 3471421 atcctttgtc attccgatcc ccgtatcaga gatggttaat gttctcgcat ctttgtcagc 3471481 tgcgaccttt atgtagtaac tgtctttatc aaacgtaagc gcatcgtccg taagcgcttt 3471541 gtaatagatt ttgtcaatcg catcactcga attggagatt aactcgcgca ggaaaatttc 3471601 tttttgggta taaatggagt taatcatcat atccagcaag cgtttagact ctgctttaaa 3471661 ctcttttttc gccactcttg atcgctcctt taccattatg taaacccttt tcagcatcta 3471721 tttatcacat aagatgacaa ttgtcaatta gattgataga tgcatatata tgtaaattta 3471781 acattagttg gatttgtttt cactcttttt ctcactcatt ctcataaaaa agagaggctt 3471841 catcatcctc tctttttttc tgtgtcattc caacggccaa actcccgctt catccatata 3471901 tgcaccgggt agaaaaacaa accgaacggt atcaaaaaca aaagattatg ccatgaagca 3471961 ttcagaaatg cgcttgcagt caccgggaac gtaatctctt gcaataaaaa agagatgaca 3472021 gtcagcacaa caaatgcaga tggaatggtc acgatgcaat aaaacttgag ctccttctta 3472081 tgctgtacct tcaaacatac aaacctccca acaatttcta attcatctta acatatgctg 3472141 gcctttcttt tctcgcatgt ttatcactgc acatagcggg aagacaaata gaaaaaggag 3472201 gtctcgtatc atgggaagac ttgaaaacaa aacagcagtt atcacaggcg ccgcgacagg 3472261 cattggtcaa gcgacggcgg aggtttttgc caatgaaggc gcgcgtgtga tcatcggaga 3472321 tatcaataaa gatcaaatgg aagaaacagt tgacgcaatc agaaaaaacg gaggacaggc 3472381 cgaatccttt cacctcgatg tgtcagatga aaacagtgtg aaagcatttg ctgatcaaat 3472441 caaggatgca tgcggaacga ttgatattct gtttaataat gccggcgttg atcaggaagg 3472501 cggaaaggtg cacgaatatc cggttgacct gtttgaccgc attatcgccg tcgacctgcg 3472561 cggcacattc ctttgcagca aatatttgat tccgctcatg ctcgaaaatg gaggctccat 3472621 catcaacacc tcctccatgt caggccgtgc cgcggacctt gaccgctccg gctacaacgc 3472681 cgcaaaaggc ggtatcacca acctgacaaa ggcaatggca atcgactacg cacgaaacgg 3472741 catccgcgtc aattccattt caccgggcac gatcgaaaca ccgctgattg acaaattagc 3472801 aggcacaaaa gaacaggaaa tgggcgaaca attccgcgaa gccaacaaat ggatcacgcc 3472861 gctcggacgt cttggccagc ccaaagaaat ggcaacagtg gcactgttcc tcgcatcaga 3472921 cgacagctca tacgtcacag gagaagacat caccgcagac ggcggcatca tggcgtacac 3472981 atggcctggg aagatgctga ttgaggagaa atggaaggaa gaaacgaaat aagagaggga 3473041 gccccctctc tttttgtctt ttaaagcaat acaaccttat atttcttcac atccaaaaac 3473101 tgcaaaaact ccctcgccag cacttcaggc ggatgcgcct ttccttcatc cagccgatac 3473161 aaaagcaacc cgataatcat tgcggataca taatgggcat aaagcttttt ctctgcgtga 3473221 atatcagttt gctgatgcag ataaaacgat tccagcgctt tgaacatatc aggtatcaca 3473281 tgaggaacac cccattcccg attgagaaaa tggacaatgg gcatgtttga caaagcagaa 3473341 agcagaatgg cgagcgcctt ctccgcttcc tttaaggaaa attcattcgg gctggaggca 3473401 atcgtcaggt gatcaatgat ctccgcacat gatcgctgta tcatggtttg gagcaattcc 3473461 tccttattgg catagtgatc ataaaaggtt gcacggcgga tattgctttt acgcgtaata 3473521 tctgaaatcg tgatgcccgc gtagtcttgt ttctccgcca atacatccag aaatgccttc 3473581 tgcagcgcct ctctcgttcg aaccacccgc ctgtcgattt gcttctcctt ctctcgctct 3473641 cctggcacag cttttccaaa cagccaataa aaccgctttt gagaaacaag ctcccatacc 3473701 ttctggctga tggcttcagg agacgcggcc gcatcctcat tcagccaata caggataatc 3473761 gcgtacgtgt acaaggcccg ataatgtcca taaatgtccc gttcaatcgg cgttaaattc 3473821 acatggatcg gagccagcag cacatcctgc tgaaacacat ccttaaaaaa acgatgaaaa 3473881 tgtcctctgt tcatcatcac agaaaaaaag gaacgatgct catgaacaaa ggacagcgtc 3473941 ggatgcaccg tttgccgttt tttgttcaaa tgaagggtat ccatatgact gaaggcgtca 3474001 aaaagcgctt tgcccagtcc ttccttcatg tcttcgatca catcctcaat gattgaaaac 3474061 ttatcctcat aataaaggta gagcgatccg cggctcactt tggccttctc agcgatttct 3474121 ttcattgtga tgtgttgaat atctctatct ttcaataaag ccagcagcgc ctctttcact 3474181 tgagcttcgg cagattccgg cacaaaagac acctccaatc attagacaga tcttagatat 3474241 atgtacggta acgtatagat ggttcaccgt tgtctttctt acagaaaagg taccacctta 3474301 taataggtcc gagaaaagaa gaaagcaaat gagggggatt ttacaatgga acagcaagta 3474361 aaggacgaca tccagcgtgt ctttcagctt cagaaaaaac agcaaaaagc cttgcgcgct 3474421 tcaacagcgg aacagcggag agaaaagctt caacgctttt tagattccgt catcgcccat 3474481 gaagaagaaa tcatcgaagc gatccgcaaa gacgtccgca aaccatatca cgaagtcaaa 3474541 aaagcggaaa tcgaaggaac aaaaaaagcg attagagata atatgaataa cctggaacaa 3474601 tggatggcgc ctaaagaagt cggttcatcg ttaagccctg acgcaaacgg aattcttatg 3474661 tacgagccta aaggcgtcac actcatcctc ggcccgtgga actatccgtt tatgctgacg 3474721 atggcgccgc ttgccgcttc tctcgcagcc ggaaacagcg cgattgtgaa gctgtccgat 3474781 ttcacgatga acacgagcaa cattgctgct aaagtaataa gagacgcttt tgatgaaaaa 3474841 gaagtcgcga tttttgaagg agaggttgag gtggcaaccg aactacttga tcagccgttc 3474901 gaccatattt tcttcactgg aagcacaaat gtcgggaaaa ttgtcatgac agcggctgcc 3474961 aaacacttgg catctgtcac acttgagctt ggcggcaaga gcccgacgat cattgacagt 3475021 gaatacgatc tgatggacgc agcgaaaaag atcgccgtcg ggaaattcgt aaacgccggc 3475081 caaacctgca tcgcacctga ttacctgttc attaaaaaag acgttcagga caggttcgcg 3475141 gggattttac aaacagtcgt caacgctgga tttatggagg atgatcatac cccagaccgc 3475201 agcaaattta cgcagatcgt caatgaccgc aacttcaacc gcgtcaaaga tctgttcgac 3475261 gatgccatcg aaagaggggc ggaagtggtg ttcggcggcg tattcgatgc cagcgaccgc 3475321 acgatctcgc caaccgtttt gaaaaacgtc acgcctgaca tgaaaatcat gcaggaggaa 3475381 atcttcgcat cgatcctgcc aatgatgaac tatgaagaca tcgacgaggt catcgattac 3475441 gtaaatgacc gcgataaacc gcttgcactt tatgtgttca gcaaaaacca agatctgatt 3475501 gacaacgtcc ttcagcacac gacatcagga aatgccgcca tcaatgatgt cgtcgtccat 3475561 ttcagtgacg tcaacctgcc attcggcggc gtcaacacaa gcggaatcgg ctcctatcat 3475621 ggggtatacg gattcaaaga gttttctcat gagaagggtg tatttattca ggccgctgaa 3475681 taatcgcatg atcaaaaggc gcttccttag aggagcgcct tttattgtaa ctccttgacc 3475741 aaaagcaatt catcacggat aggtatttta ttatctgcca gtaaaggaat ttcgggcttc 3475801 atctttctgg ccgtctcgac tgcattcaca aatagtcgat ccaaccggta ccctctcttc 3475861 tgataaaacg ctaatgcatg aatattatca ttggttgtga tcagttttat ttgtttgata 3475921 tttctctctc tgcatgcttc ctcggctttc tctagcagag ctgttccgat ccctttattc 3475981 tcaatgacac tatccagcga aatgatttca caggcatctt cttcaaatat gtatgtaata 3476041 aggccaacaa tctggttatc atcgttgagc attccataac catctaattc atcgcagtta 3476101 taaataccgc tagaaataac catttgcgga ctgccccagt gtttttgaaa aaacgcggaa 3476161 acaagatctt taggtacctg gcatgtcgga ataatattca tattttcctc cttttagctg 3476221 aacaaaaata agagaattaa caacctattt tatgtcatta atccccttat ctagtattta 3476281 ctagaactta taacttgtca aaagctgtct gaataccaat tgcgtggatt gataaggatc 3476341 aaaatctgaa tcctgagatt ggaagatttg ctctggggtc aatgtctctg cgttctctga 3476401 taacgtttga atcagacttt ccaaatatcc atttaactct gatttggacg attcatgtag 3476461 ggattgatga tttacagcga gttctctaaa tctgttatca ctgattaatt tttttcgaag 3476521 agctgctagc atcaagtcaa gccatgcagg ctggccaaat gtaatattta aagctaacgt 3476581 tgcttgatca gatttggtgg agtgccataa acctcttggc aaatacagca tggttcccgg 3476641 tgttaaatta acgatttctg catctggcag atcctctttt ggcggatctc ctttccaata 3476701 tgactgtaaa tcatcaggat agtaaggagc ctctgataaa tcatagtgct gcattggatt 3476761 gctcacattt tcattcttgg caagcttcca tgttttctca ccttgaattt gaaaaatcaa 3476821 gttggtgtag gcgtcaaaat gggctttgaa tcccccgcca tttttcgccg cgtaaacaat 3476881 ggctttggaa gaagtacccg caggcagtct taattccgct ttgagttttt ctatccacct 3476941 tctgacttgg ggaataaata ggtcggtgaa atcaaactct aatgcagccc ctttttcata 3477001 ccactctaaa gcctctgcag gtgacacaag aaatctgtct gtgatccctt cagattcttc 3477061 aatcacagca tcaccaacga ccatgactgg attattgtag atagccaata cgttttctag 3477121 cgttctaacc ttttcaaacc ccggtatgct tgtaaatctc tccacttctc ctctggctac 3477181 caaaggtttt acaggccaat attcttctaa aaactcactc atcgttacag gactgatgat 3477241 agactccaaa accgattcgg ttacagcact catattatcc ctcccaaaaa aagtaacttc 3477301 accacaaaga tataacattt ttttctaaaa gtaaatattg acagaattat cagaggatta 3477361 taatatttag ttgtgcgtga tagcctattt ttttacaagg aaggagggaa aaggatgaaa 3477421 aaggcttata agaaacctcg tctttttgaa ctgcgccgtg ctgtagcagc tggcggccat 3477481 taatctcata tagcatttga catctagtac tctattttag gagggatgct caatgaaaaa 3477541 agcttataag aaacctcgcc tttttgaact gcgccgtgct gtagcagctg gcggccatta 3477601 atctcatata gcatttgaca tctagtactc tattttagga gggatgctca atgaaaaaag 3477661 cttataagaa acctcgcctt tttgaattgc gccgcgctgt agcagctggc ggtcattaat 3477721 cttatccaaa acgattaacg tttgaggcta tcacgccaac ttgataagga ggatgctgaa 3477781 gatgattacg gctgaagaat gcagaacgta caaagaattt gttgatcttt accaatccta 3477841 tctttacccc ttgcttggcg ccagactgtc ccggatgtat tcccccaaaa acaaagtcat 3477901 tatcgatatg ggcacaggtc caggttattt aagcattcag ttggctaaaa gaacaaatgc 3477961 gcacgtgcat gctgtcgata ttaacccggc catgcatgaa atcgctcaag aagaagctaa 3478021 aaaaagcgga gtaagcagcc tgatttcatt tgatttggaa gatgtccacc atttatctta 3478081 cgctgaccaa tatgctgact tcatcgtctc ctactcttgc ctgcatcatt gggaagacgt 3478141 tgttaaagga cttaaagagt gctatagagt tctggctccg ggcggaaaaa ttgtcatttt 3478201 ggatacattt aatccccaag gaagccattt agagattatg cgaaaacaaa tcaaagaacc 3478261 ggaatacttc aggtttgtaa gagaggcatt tgaagaaagt tattcctttg aagacattca 3478321 ccagtttgtt caggatgccg gcattcccaa ttattcatta gaaacctttc actttttacc 3478381 ggaggatttt atagaaagct tagatgagct ggaggatgct cccctgtggg aacaaaatga 3478441 tcaaagtact gatcatgaaa ttgagtctgt cacatggatg ttaacgatag aaaaagaaaa 3478501 ggaaggtgca ttgtaatgat caatgaatca actgttttat ccaaaaatcc agaaatgcca 3478561 tcaagaaaat atttgaaaag cattattata gagccgggca tcactttaaa tgaaatggca 3478621 tcagatattt ataaccatat cgacggcaag gtcagcatac atgatatttg ctcaaaaatc 3478681 gtcaatgaat atgatgttga ttatcaaacc tgcttagaag attgtatgga gctgtttgag 3478741 ttgcttattg atcatgaagc aatcaaagtt aagcaggggg catgagaatt ggaaaaacaa 3478801 aaagtgcttg ctttaccaga cgatgtacat gagctgagta cacaccgttc taaatcaatc 3478861 gtaaattaca tcatcactct gcttgccttt gccaaaaaac aaggattgac tcatcaagat 3478921 attgtaagct ggattcacga gcaatatgag gaaagaggat attatgatga gtggagacac 3478981 attaacagcc aacaaccagt tggatcattt gtggaactct ttataaaagg aagacgttta 3479041 ctttatgaca aaattgaatt gtttgaaaca gaagataaat atgtcgtaaa tacccacact 3479101 tggtatgaaa aagaacctag tgaggccttt ttttattttg aaattgatcc cgaagaattt 3479161 tctgcgtacg cttccattct cgcaatcgaa aacgcaaaac gtctcggaat taaaatcgat 3479221 attgtaaaag aaacagatgt agagacagct tatatctata aacatcaata acgctattgg 3479281 gagggagaca tatgtgcggg ctcgcgggta ttataaatct ggctgctccc cgttctcagg 3479341 aatgtacctt tcatatattg aaaggcatgg cagatgccat cagctatagg ggaccggatg 3479401 atgaacaata tcatattgat tccaaagtcg gctttgcatt tcggcgattg tccattcttg 3479461 accttgtaaa tggacagcag ccctttttaa atgaggatgg atcaatcgtc gttatggtaa 3479521 atggagaaat ttataactat aaagaactga aggcttcttt acacaatcat atgtttaaaa 3479581 cgacatctga ttgtgaagta attgttcatt tatatgaaga aaaagggatt ggatttgtag 3479641 acgacatcat cggaatgttt tcaatagcca tttgggacaa aaataaaaac aaagtatttt 3479701 tagttcgtga ccgctttggg attaaaccgc ttttttacac agagctaaaa cacgagctta 3479761 tatttgcctc tgaaataaaa tccctatttt ctcatcctca ctgtccccgc caatttaatt 3479821 ggaaagaagc actctcagac atttggctaa gcggggaagc agccagtaat cataaagaaa 3479881 ccacttcctt ttttgtaaac atccaaaatc tcgatgctgg ccattatctc gaaattaatt 3479941 tgacaacaaa tgaacgaaaa acagcaagct attggtcttt acaggatatt ttgctcaggc 3480001 aaggctatcg tgagaatctc catcccgatg acctgattga aggatataga gaactgctgg 3480061 cagattcagt ccatagatgt ttacaaagcg acgttgaagt cgggttgttt cttagcggtg 3480121 gcattgattc agctgcagtc gcacattttg ctgcagaaaa acaggatctc catacgttta 3480181 cagtattaag ccaaagtaca tttacaaatg aagatgcaaa atatgcccat tggctggcta 3480241 aagatttaca ccttccaaat catcaggttc tctatcaatt agggaacgat gagttattac 3480301 aaccagagtc atataaacat ttgttatgga tctgtgaaac accgttttgc ggaccggaac 3480361 aattatataa gtttcattta cataagtatg ccaaagcgat aaggccaaac ctgaaagtca 3480421 tgctgaccgg ccagggcagc gacgaattta acggcggtta cagcacgaca ctttcaccag 3480481 ccgagaaccc aagttgggaa ggatttattg aatcggtcaa tacgatggag atgaaccggc 3480541 tgcatcggct gcagggaaat atctttagag tgtgggagga gcattttgga ctttctccta 3480601 taaacctttc ttatttaaag agcaatgatt ccagccaagc agatccttgg caatcgtatg 3480661 tcctgacaaa ataccgtgat ctgcaaatgt ataattgctg gcatgaagat cggatcgccg 3480721 cggctaatca tatcgaaaac cgtgtaccgt tcttggacca tcggcttgtt gaatgggttt 3480781 gcggaatacc tgatggactc cgtaaagact tgttatggga taagtcggta ttgcgaaaat 3480841 cattaacaaa tgagctgcat acaagctata cccaccggcc aaaggttcct tttttctatg 3480901 gtaaggacgt gagatataca cataaaatga tgtttcatct tctgaagaaa aacaattatc 3480961 agcttataga ggaggccttc tctcacagcg atgcctccag cataatacag gttgaacaca 3481021 ttcatgccat catgacatat ttggaggatg atcctgagtt tacaaatttt gaatttttat 3481081 taagactggt gaacatggga cttttatcaa aaatgactaa agaaacccct tctgttcaat 3481141 tagacataac cagccattta gaatcgataa caataaaaga ctggcactca caggaaggtg 3481201 atattgccag tcgtttaaat atctcagcca ataagtgtga aggacaagat attttggcgc 3481261 taaaccctgg cgtcactctg ttaaggccgg aaagcgatag tgagcattgc atctacattg 3481321 cggaagaagg atttattcag tttattgttt cggaggaaga cgtcggagct tggctgcata 3481381 ttctctgcga tattaatgga aaagacacac ttcatacgat tttagacaga catggtgtca 3481441 gccttgaaga agtggccaaa tatattcaag aagccatcga acacaatatc attttgatca 3481501 aacaaaaaaa tctgccagaa ggagcatata gatgagcatc ttttattcgt tttccgcact 3481561 taggggatta gcaatgggga ttttttcgcc tatttggatt ctttatctga tatctaaaga 3481621 ttatgatttc cttcagattg gattaatggg agcggtactt gaaattgcta agcttatatt 3481681 tgaagttcct tccggcgttt ttgctgatcg ttatggaatt aaaatttcaa ttgccagttc 3481741 attctttttc tccatcctta catgggcctt cttccctttt atcgattcag ctgctatttg 3481801 catactggct atgatcatat gggctttatc agattcctta atttccggtt cttttgaaac 3481861 ttggatgagc cgtgtcgcag gggaagatcg attcggcaaa gaaatgatga aaaacacaca 3481921 attgctaatc acttttttaa ttattggaag tattgccagc gggtatttgt attcattaaa 3481981 tatctatttt cctttcctgc tcgttatggt gatctactta ttactattta tttggatgtc 3482041 tgtatttatt aaagtccctt ctgtttccga aacaaatcat ggggatcaga accaacatga 3482101 ttcgataaag attatcaaag aaagtttaaa aattatcttt aacaaaaaaa gggttctttt 3482161 aatcgtcata gccggtttct ttacagccac agcctatgac acaatttccc gttactggca 3482221 gccttttttg agtgatttag gcttttcaga aaagtcactg ggatatattt ttgccctagg 3482281 agggtttacc gctctcgttc ttttgacatt aaccatcagg ttcgaaaaga agatcgaaaa 3482341 aaatccatat ctcgctttaa cctcattgga ttccatgggc atggtcatga cttttctatt 3482401 gtctagagca ttcaggccgc tgggcattcc atgtacagcg tttttgcttg caattgaaga 3482461 tattcatcat ccgatcgtaa caagttactt aaataagttt ttccccgatt catacaagaa 3482521 cacacttttc tcgttaaact caggggtagg agcaattgga gaaattcttt ccggtgtcat 3482581 tttcggcatc atttccgcag cctttgggct ctctgccatg tttgttgttg tagctgtatt 3482641 tctattaatc cctattatcc tttatacgat agtgcctaag attaaagaca atgatatgaa 3482701 agttcagatt gaaaaatccc agcaagtgta aatgttttgt atcacagtaa gaagaccttc 3482761 ttattaaaag aaggtcttct gctattctat tcagttattt cccaaaagcc atcagcttcg 3482821 tataacttcc aatataaagt gttccgtcct cagcgagctg aggagaagac acgacgttgc 3482881 tgtcggtttg atagctccat aattcattgc cgtttgcgtc tgccgcataa accttcatat 3482941 catctgaccc gaaataaacc gttcccttcg cgtcaatcag cggcgccgtt ctgacagggc 3483001 cgtctgtgta gaatgaccag ttcatatccc cgtttttgct gatggaaaac agctcgccgc 3483061 ttcctgagcc gatgtagata ttgccattat gatcaatcgc aggagatgag ctggagaacc 3483121 cgtttagcgg gaatgtccat ttcaaactgc ctgttgatgt ataagcatac agctgtccat 3483181 cttggttgcc ggcataaatg tttccgtcct tatcaatcac cggatatcct ttaaacgcat 3483241 ttgacgtcgt tctggaccat ttcacctgtc cggttccgga gttgatcgca taaaacacgt 3483301 aattatatgt gccgacatac acggtgccgt ttttggcaag caccggcaca gagctgacga 3483361 ccccatttgt tttcaacttc cagcgctctg tccaggttga ttttgacgtc ggtttgatcg 3483421 cgtgaacata attatcaagt gttgagaaat acaacgtccc gtctgaaccg atcaccgttt 3483481 cagagcttgg cccgccgctt aacggaaccg ttgttaaaat ttctcccgtt tctttgtcaa 3483541 taaaataaat ctttttgtca taggatgcca aatagataac gccgttggtc ccaagtacag 3483601 gagattgcgt atatgttttt ccaagattgc ccgtcaccca tttgactgag ccgtctggat 3483661 taaaggcttt catttccccg tctctggaat gaagatatac tgtgccgtct ccgtcaatca 3483721 cagcccccgc tccattttgc ggagtcgttc tgatgtcgtt ttgccatttc agcgtcccgt 3483781 ctgtatttcc ggcgaaccgg ctttcgcgtg accagttaaa catggcaggc gccatcgctt 3483841 gtacatcata tcttcctggc aaaaagccag atgctccatt attttgagaa aacaccgttt 3483901 ccgccgcata agcagctgtc ggctgaagca ctttggcagc gggcacatca gaaacagcgc 3483961 cggccgaaac agccgccgcc accgcagctc ccgcaatcaa agctttcata cgaaatgact 3484021 tgaccatcat tgagaccccc attatatgta acttctaatt tgtgaccatc ataacatatt 3484081 catccatttt ataaatctat ttcacaaaaa catcacaaac tagaaaacta tgtaagagta 3484141 ttcacggacg ttttttcagc acccgatcga aatgcagcca caaaccaaat gacgttgaca 3484201 gcagccgcag cgagactaac tcccaaaaca aagatcacct cagaaagcag atggtcacta 3484261 aagaaactaa acatcaagat aaaaccggcc gaagacaaat gaatcaaaag cccgaagccg 3484321 caaagcaccg ccatgacata cctcattgca tcgactccga gcatataaac gagaaatgga 3484381 atgaaataca agacaaggat cataccgaca gctgaccaca tgccagctga attaaactga 3484441 ttggccgccg ctcccgttcc ggccagcggc gaaagtgaag ccgccacaat cacggcgcaa 3484501 aaaagaaacg cagaaatggt tgtcatgatc gccacgctat ttttttttga catcaaactc 3484561 ctcctttaat agaaatatta acctttttta ttataagtaa gttgaatgtt atattcatta 3484621 tatttttaaa aaattccaga atacatacac aaatgctatg cttctttcta gtatatttat 3484681 atagtaaaaa acaaaggata aaagactcat ttttctgtaa tatcaggatt ttatcaccat 3484741 accatattgc atgtacatgt ttttcaaagt atactattcc agattaattc agaggagaga 3484801 gaaaaataca tggaaaaacc agcaggattt tggattcgtt ttttagctta ttttattgac 3484861 ggcattattg tatctgttcc tagttatatt attctattta ttatcaattc tgtgtttgta 3484921 gctggggctg tggcaacaaa cccttacatg acggaagaag agtatttagt gaaatacatg 3484981 acgcttgcat ttttgcctac tatgctgatc atgatcgtca tcagcgtgtt atattacggg 3485041 ctgctcacag cttctaaaat gcaaggcaca cttggcaaaa aaattcttgg cctgaaagtg 3485101 gtcaatgaac aaggtgaacg ggtttctgtc ggacagggaa ttggccgtta ctttgcctat 3485161 atcttatctg gaatcatctt ttatatcggg tttatcatga tcgcctttgg agagaaaaaa 3485221 ggcctgcatg acatcatttg caaaacacgt gtcgtgtata aataatagaa aaaagtctag 3485281 acgccaatag gcatctagac ttttgttttc tttgcaatag gctgccacga cagatacgta 3485341 gcgcttctcc acaaccactc aaacggcccc atccgaaaga cacgaagcca aaggtggctg 3485401 aagaccattt gaacggcaca aacagcaatt gtaatgagca caccggcagc agggtacact 3485461 tttccataca ggcccaagcc gtaatgataa aaaatccaag tacacacaat agactgcatc 3485521 aaataattgg taaatgccat cctcccaaca gcggagaatg attgcagcac tgttctcact 3485581 cttgttttat gataaagata gacaaccgtt gtaacataga aaaacatgag gaaaggcgcg 3485641 ccaatcagca aacatatttc tttatccgtt acactgtaca gcacctgggc gccgatgccg 3485701 atgacaagcc cagccatcca taatcgtttt aatcctttgc gatgcttttc cggttcatgc 3485761 aaataccgtg attttgctgc cgcagctccc agcaaaaaca tgctgaaata tggaatggat 3485821 gcaaagaagt agttgagcgg attatacgta agcatgccat tcgaagacat gtaaacaaga 3485881 cggtcgtgga tccgctgttc tgcaatatcc ttcaggctgc cgcttccata aacatgaatc 3485941 gcttgttttg cctgctgtgt taccgcttgt acccattcct gtccgtttga ttgatcaaaa 3486001 cttgtcaaca tgaacggaat ggaaaacaga agatacaaag agaccgccca tatcagcagt 3486061 gttttcggct ttgcttttcg aaacaagagc aggacaaatc cgagcagggc atattctgtt 3486121 aaaatatccc cgtcccatat caaaaaggca tgaatcgttc caaacaagag aagcgccatt 3486181 aaccttctca catataacgg aacaaaccgt ttccctttgt tttctgctct ctccatcatg 3486241 acaaccatgc caaatccaaa taaaaaggaa aacaataaaa tacattttgt ttgaatgaag 3486301 aatttcagta tgtctgcggc ggcaaaatca gcttcagacc acttatccat gaaaaaattc 3486361 tcttttccaa gcatagacaa atacatatcc ggataactga aatgtgccag attgacaaat 3486421 aagatgccga aaatcgccat tcctctcagc acatcaagca caccgatccg ctcatttgtt 3486481 aaagtcggct gtaatgaaga catagccatc acgctccttt tttctgtacc ttaagggtag 3486541 gaaaaaatga agcgcggtaa catcgattta ggtgtcaggc cggcatgaaa accttacaat 3486601 cttgtcatct ttatggtttc atcaccttta aatctaatgc ttcgatattc tgcaaaatgc 3486661 gatcaaagcg caaagcctga ggctcacatg ggaagatgtg gccttcatac gggtcgccta 3486721 acgtccggaa aaacggttca aataaaccag gaaccaatac gcccaccatc tttgtatagt 3486781 gagaatcaag gcgataggag tgaacggtat ttgcagggac atgcaggaaa tctcccggat 3486841 tcagctgaat ttcctggcca tctgtccaca tcgtcatctg gccttcaagg caataaaatg 3486901 tttctgtatg atattcatgg tagtgatcaa cgattcggtc acctttaggg ccttcagatg 3486961 atacgacgat aaactggcca tctgtatttt tttgtgcagc cacaatgcgg tgaagctgat 3487021 ctccagtcaa cagacgatct ccttctccag attcaagaac gtatggaacc gctccatctg 3487081 gcagctctgt aagttccgct aatttggccg aacatgcagg ctttgcttca tctagaaata 3487141 caatgtccgc tacagcggct gcttctgcaa atcgctcgtt tgagacttct tcgcttgcgt 3487201 acggcggatg ttcagcgtga tcatacggat tcccaataac ggaatacaag tgcgctacgt 3487261 ttcctttcat cgtgtaagac accagtcttg ttctgtggct ctgcatccgg tagctgtgcg 3487321 gtgttcccgc cggaatgttg gcataatcac ctgatattaa taaatagcgt tcaccatcaa 3487381 gtgtcagttc cagtttcccg tccaaaacga gaattccttc atgtgtgtcc ttgtggacgt 3487441 gaagcggaaa ggcatctcct tttcccccgg aaagaagcac gatctcaaac aaatcacctg 3487501 tgctcctccc attcgccatc accgtggcaa cctgtctgcc gaacagatag cgctcgcctt 3487561 ctccgctccg gagcaaataa ggcatttttt ctttaggcaa tgaatgtgta cataatgttt 3487621 tcatattatc gcttcctcca atttagacca gtctatatat tatcattcat ttgtctagac 3487681 cgttctatat aattgtagga gaaaggataa caaaatgcta cccttttttt ctcaccagca 3487741 ctggtatttg ttcggcaatg agaagaagag gcgttttgtc tttattcgtt aacgaaagca 3487801 tgatgccgcc ctcaatcatc gaattaatca gcgttccaag ctgatttgct tcttcttctg 3487861 caaatccgtt ttccattaat tttctggcaa aaaccgcttc ccagctttta aacaccttca 3487921 tgcaaaccgt ccgcagcggt tcactgatta acgctgtctc actcgccagc aaaccgactg 3487981 gaataccttt aatgctttct gtgttgtcaa attggctggc tgtttttttg ataaaaagct 3488041 gaatcgcttc aacaggatca gaggattcat ccatgctttg ctgtatcaga tgttcaacga 3488101 tcttacctgt atatgtaacc gcttcaattg ctagttcttc tttgccattc ggaaaaaagt 3488161 gataaagcga tccttttgga gcaccgcttt cttttacaat ctggttcaaa cctgtcgcgt 3488221 gatatccttg cagctggaac agacgtgacg ccgtgtgaag gattttttca cgtgaatctc 3488281 ctctgctagt cattaaaaca ttccctccta ggtatggtag agcgacttat ataatataaa 3488341 aaagaaccct gtgattgtca aaaggggtaa gacccttccg gatggggtaa tgtacaaaaa 3488401 cagcgtctag gagggatctc tcaatgacaa tcgatcattc agtcacaaat acagagcagc 3488461 ttgaacaaca gaaccccgcc ataaaaacaa agctcaaact gaaaaagctt aaggatcagg 3488521 tgatcgtcat taccggcgct tcaagcggta tcggacttgt cacggcgaga atggcagctg 3488581 aaaaaggcgc aaaggtcgtg gcagcagcgc gaaatgaaga ggcgctgaag gagctcactg 3488641 atgaacttaa ggaaaaaggg cacgacgcca tatgggtaaa ggcggatgtc ggaaaagaag 3488701 aggacgtcaa ccgcatcgca gaaaccgcga tcagcacatt cggccgcttt gatacatggg 3488761 tcaacaatgc ggccgtctcg actttcggac acgccatgga cgtcaccgtc gaagacatga 3488821 agcgcatgtt cgacacaaat ttctggggac ctgtttacgg aacaagagcg gctgtcaaac 3488881 actacaccgg cagaggtgtg ccgggcgcac tcattaatgt aggaagcctg ttcggagaca 3488941 ggggaacggt cattcaatcc acatatgcat ctgccaaatt tgcgcttcac ggctggacgg 3489001 aaagcatccg aatggagctt gaaaaggaac aggcgcccgt ctcggtaacg ctcatccacc 3489061 cgggcagaat tgacacacca tataacgagc atgcgcacag ctacctcgac aaacagccgg 3489121 ctcattaccg ctccatgatc tatccgccgg aagcggtcgc cgaagcgatc ctgtttgccg 3489181 ccgaacaccc taagcgcgac atgtacatcg gctcacaggc caaagccatc gccatgctgg 3489241 gcgcgctttt tcctcgtctg accgacagac tgatggaaaa aatcatgtat cacagccagc 3489301 atgccgaaag accgtccaat ccgagagaag aaagcgctct ttatgatgct ggctgcggta 3489361 tgcatgacag aggcacaaat aaaggatgga tgaggtcaag aagctactac acaaaagcga 3489421 cgaagcgccc aattgtatcg gcggctgttg ttgccggact agtggcttgg gctgccgcca 3489481 aacgatgcag ataatctctg accataagaa aaacccatgc tgttccagcg aaccatgggt 3489541 ttttcagctg ttaatcgata aaagccttgt tcatacgctg cagcagctcg ccgaacatct 3489601 ctttttcctg tgttgaccat tctttcagca tctgttcata acgttcaagg cgcttttgct 3489661 gatcggcttt taatagttgt ttgccgagtt ttgtaatggt aaacaggctg actctcccat 3489721 cagacgggtc tgagaaacga tagatgagct cctttgcctc taatgcagct gcttgtcttg 3489781 aaagagtaga aatatcaagc ttaaacgatt cagccaattc cttaacacga gcaggcccaa 3489841 actcatccaa ttgtctcagt aataagtacg aagatctctc caaattccct gttcttttct 3489901 ccgattgatc cagataaaca gctctcctga taaaagtcgt cagctcatat tcaattaatt 3489961 caactggatt ttgattttgc aatcgctctc gctccctatt ccaatctccg gcattgacaa 3490021 catcatatat acttgtataa tacaaatgta cattaactga ataaatacaa gtcgttatat 3490081 gactaaatca attattatac ttgtatagta caatcatata aaaagaaagt aaagcgattc 3490141 ctcagaacca tcctagaagc aagcaccaga aaggaggaag ctgttctgat tggagagcag 3490201 cacttgatgt gaaagtcata cgaattattt tgcaagtgtt gatattatat gtatttttta 3490261 tgatcgggga agccattcag catctgtttc atttacccgt gtcaggaagc atcgttggat 3490321 tggtattgct tctgatctgc ttgggcctcc gtattgttcc cgtctccatc attgaagacg 3490381 gagcagggtt tttattatcc ttccttccat tgttgttcat cccggcaatg acaggagtga 3490441 taaactatcc gtctctcatt tcattcaatg gcctgatgct gctgattaca gtcgttctca 3490501 gcaccatcgt cacgatcatt gcggctggat tcgccagcca gctattagag aaaaaagcaa 3490561 aaaaacggga ggagaaagag aaatgcagca agcatgtatc gcgatcatta taattctttt 3490621 aacagttgcc gcttatttag cgatggtcaa actctataag cgattcccgc ttccatttct 3490681 gatccctgtt ctgacaacga caattttgat tgtagcggct ttgatgatgt ttcatgtttc 3490741 ctatgaaggc tatatgatcg gggggaaatg gatcaattct ttgcttgggc cggctgttgt 3490801 ggcgctggcc tatccgcttt ataagcaatg gcatatcatt gtcaaacatt gtgttcccat 3490861 tttaggcggc gtcctggtcg gcttatgcat gggaatgatc agcgggctga tcttcgcaga 3490921 agcattcggg attgatcatg atctcttatt atccattctg ccaaaatcga tcacaacccc 3490981 tgtcgctatt cagatcgccg ccggtcttgg cggcgtccct tccatgacag tcgtatttgt 3491041 catgattgcg ggcttttcag gcgtcatcct cgggccgctt ttcctaaaat ggcttcgcat 3491101 acgcagctcc ctaggacaag gcattgcatt aggcagcgcc tcccatgcac tgggtacctc 3491161 caaagcgttg gaatatgggg aattggccgt atccatgagt tccgtctcca tgacgctttg 3491221 tgcggtgctc ggctcattct tcggcccgct cgtcgtctgg ctgtttcata tttaacaaag 3491281 aaagactgcc ccgggggagg gcagtctttt tcgtttaaga agcaaaaaaa tcaatcaacg 3491341 gctgaaagtc cttagataaa tcaacgtcat tcggttctgc ttgaagcagg cggtcaatca 3491401 tacgctccag ctcctcaaca tcattcttat ccgtatattc aatgaagttt aagctttcaa 3491461 gccaatcccg atatgaatgt ttggctttgc catagctgtt tccaaagaca aggcaaggtg 3491521 ttttggtgat aatcgagaaa atcatcgcgt gaaggcggtc ggtaatcacc aatttactgg 3491581 agccgatgcg gtccagcatc tccataaaat gcttttcacg atcagcgtaa tcgatggtgt 3491641 ctaccgtatc cagcaccgta tcggtacgct ctgtgtaagt tgttttttct gcccattgct 3491701 tcatctgtga aataaaatct tcgtcagtca ctttctcctt atccgctctt aaaataaaga 3491761 gaacgccgtc ccgctcgagc tctcgcggca caatatccaa ggaaagcacc atgtccggtg 3491821 taaagatcac attggagttg aaggtctctt tcacaacatc cagtgtttgc gtctcacgcg 3491881 cagcaatcgt taagtttgta ttttgatggt acgcatcctg tgtttttttc ttttccttct 3491941 gtccttcctc tgtatcctca aaataaacgg attgtggcag agaaattgat ttgtagtctt 3492001 taaacgccga aaagaccttt cttctgtctt cctcaatatc gagataaagg tttcctaaat 3492061 tccctccgcc tgtaaagcag acaatatcgt cttcacgaat gatctccttc accagttcaa 3492121 tgccctcatc cgtcgcataa tccataatct caatgtattc ataatacgga aaatgatttt 3492181 tgataaattt ctcttccgca tacgcaatcg cttggtcgcc aatgtttgtg tagctagggg 3492241 aaccaaacaa aaatactttt cgtttatcat ttaacagagc ttccggctcc acatttggcg 3492301 caatgccttt tactagtttt ttgcctttga tttcttgtac agtcatatct gcgtcctcct 3492361 tctgggatga attcctcatt gtgtgttaac tgtctctacc caaaaagaag gatggctatg 3492421 cattggcatg tgcatcggct atatcagaaa catcgttttc gccaatttga tagacgctgc 3492481 aatgtcccgc gccgttcttt ccatatattc cgcggcatgt tcaaacgcgt cttctagtgg 3492541 cacggctccg gggacgatgc tgaaaagcgc atcgattccg tgttgataga cggcattact 3492601 gtctcgggaa attgatcccg caatgccgat aacgggcaca tcgtatgatt tagcggcctt 3492661 ggccaccccg atcggtgttt ttccatgaac cgtttggctg tcgattcgtc cctcgccggt 3492721 aatcacaagg tctgcatcct gaacgatact ttcaaaatca accgcttcaa ggacaatatc 3492781 aatgcctctt ttcaggtcag cctgaagata agttagcagg ctccatccaa gaccgcccgc 3492841 tgcaccggcg ccctctgtat ctcggaaggt tgatccgagc gctttttctg ccatatcagc 3492901 gaaatggctt acgttctggt ctagtacatc caacatgtcg gccgtcgcgc ctttttgcgg 3492961 cccgaaaaca gccgtagcac cctttggtcc tgttaacgga ttgtccacgt cacaggcaac 3493021 ttccagtttg acattccgca atctggaatc aagcccgctc acatctattg atgcaagctg 3493081 agataacgcg ccgccccctg ggccaatctc gctgcctgag ttatcaagaa gccttccgcc 3493141 caatgcctga atcatcccgg ctcccccgtc gttcgtggcg cttccgccga ttccgatgat 3493201 caatcgctcc gctcccgcat caagagctgc tccgattaat tctcccgttc cccttgttgt 3493261 agtgatgagc ggatttcgct tatctacagg caccagatgc agccctgaag cagcagccat 3493321 ttcaatcaca gctgttctcc catctcccat catgccaaag aaagctctca ccggttcccc 3493381 cagcggccct gtgacaactt gctctatgat ccttccattg gtcgcatcga ccagagattg 3493441 aacggttccc tcgccgccat ccgccaccgg caattttctg taatcagcac ccggaaagac 3493501 cgatttgaaa cctctttcta tcgcttcggc tgcctccaga gctgataagc tttccttaaa 3493561 agaatcaggt gcaatgatga ttttcatcca aatcgcctct ttcaaaacat gattcactta 3493621 acctattgat ctccaatgta ccataattga tctggaaata cataccatgc aatatggtaa 3493681 aaatttaaat aaaaattaga aatgaaagtg tttgcataaa agaaatattc acgttatcat 3493741 acttgtatac aagtatactc cttgagtgag gaaggtgagt gtatgctaga ctccaaagac 3493801 ctgttgtatc ccgcaaaatg gctctcaaaa gcgtcaaccg gagttcgtgt cgcatacgag 3493861 ctgagaatgc ggatcgtttc aggtctgatt gaaagcggta ccattttatc agaaaataca 3493921 atcgccgccg agttttcagt aagccgttcg ccggttcgcg aagcgctaaa aatactcgca 3493981 tccgaaaaaa tcatccgctt agaacgaatg ggagcggtcg taattggttt aactgagaag 3494041 aaaatcgcgg aaatttatga tgtgcggtta ctattagaaa catttgtctt tgaacggctt 3494101 gtcaaaatag acattgagcc tttagttaag gatctcagca aaattcttga aatgatgaaa 3494161 gtctcaatca aatatgagga tgctgacgaa ttttcatttc aagatgtgct gttccatgaa 3494221 acgattatcc gagcgattga tcattcatac attcagatga tctggaacaa tctaaaaccc 3494281 gtcatggaaa gctttattct tttatcgatg cgggtacggt taaaggaaaa gtatgaagac 3494341 ttcacaagga ttttagataa ccacgagctt tatattcaag ccatcaaaac aaaggatagg 3494401 gcgctgatga ttcagtctct tcaccaaaac tttgatgatg tgcaggataa ggtagaagac 3494461 ctatggctct cacaacaaat gctggcaaaa ggagctgaat acaacaatga ctagttatat 3494521 gttaggaatc gatatcggca cgacaagcac aaaagctgtg ctgttcagtg aaaacggaga 3494581 tgtggtacag aaagaaagca tcggctaccc gctctataca ccggacatct caacagctga 3494641 acaaaatccg gaagagattt ttcaggcagt catccataca acagcgagaa ttacaaaaca 3494701 gcatcccgaa aaacggatct ctttcatttc gttcagcagc gccatgcaca gcgtcattgc 3494761 aatcgacgaa aatgacaagc cgctgacgcc atgcattaca tgggccgaca acagaagtga 3494821 aggctgggcg cataagatca aagaggaatt gaacggacat gaggtgtaca aacggacggg 3494881 aacaccgatt catccgatgg caccgttaag taaaattgcc tggatcacga atgaaagaaa 3494941 agaaatcgct tccaaggcaa aaaaatatat cggcatcaaa gaatacattt ttaaacagct 3495001 gttcaatgag tatgtcatcg attactcatt ggcatcagcg acaggcatga tgaacctgaa 3495061 gggcttggat tgggacgaag aggcactgcg catcgcaggc atcacgccgg atcacttatc 3495121 caaactcgtg ccgacaaccg agatctttca gcactgcagc ccggaaatag cgatccaaat 3495181 gggaatcgat ccggaaacgc cttttgtcat cggcgccagc gacggcgtgc tgtccaacct 3495241 cggcgtcaac gccattaaaa agggtgaaat cgccgtcacc atcggtacaa gcggtgccat 3495301 tcggacgatt attgacaagc cgcaaaccga tgaaaaaggg agaatttttt gctatgcctt 3495361 gacggacaag cattgggtta ttgggggacc tgtgaacaat gggggcatcg tccttcgctg 3495421 gatcagagac gagtttgcct cctccgaaat cgaaacagcg acacggctgg gcattgatcc 3495481 atatgacgtg ctgacgaaaa ttgcccaacg cgtcagaccc ggttctgacg gtctgctgtt 3495541 ccacccatat ctcgccggag aacgcgctcc gttgtggaat ccggatgtac gcggctcatt 3495601 tttcggcttg accatgtcgc ataagaaaga gcatatgata cgcgcggcat tggaaggcgt 3495661 catttacaac ctgtacacgg tgttcttggc gttaactgaa tgcatggatg gcccggtaac 3495721 ccgcatccaa gcgacagggg gttttgcaag gtcggaggtt tggcgccaaa tgatgtcgga 3495781 tatcttcgaa tcagaggttg tcgttccgga aagctacgaa agctcatgtc tcggcgcctg 3495841 cattttaggc ctgtatgcaa caggaaaaat cgattctttc gacgccgtgt ccgatatgat 3495901 cggcagcaca tacagacata cgccgatcga agactcagcc aaggaataca gaacattaat 3495961 gccgattttc atcaatctat caagattatt agaaaatcaa tatacacaaa ttgcagatta 3496021 tcagaggggc ttaatcacac acaaatagta catgacatga aggggagggc attaccatgc 3496081 cgttaatcat cgttgcactt gggatcttag cattactatt tctgattatg ggcttaaaat 3496141 taaacacatt tatttccctg ctggtcgtat cgttcggcgt ggcactggca ctcgggatgc 3496201 cgttcgataa agttgtcagc tccatcgaag caggaatagg ggggactctt ggccacatcg 3496261 cgctcatctt cggactcggt gcgatgctgg gcaaactgat cgcggattca ggaggcgcac 3496321 agcgcattgc gatgacgctc gtcaacaaat tcggtgagaa aaatattcaa tgggccgttg 3496381 tcattgcctc attcattatt gggattgcgt tattttttga agtaggactg gttctattaa 3496441 ttccgattgt ctttgcgatt tcaagagaat tgaagatttc tattttattt ctcggaatcc 3496501 cgatggtcgc ggcactatcc gtcacacacg gtttcctgcc gccgcacccg ggacctacgg 3496561 cgatcgccgg tgagtatggc gcaaacattg gagaagtgct gctgtacggc tttatcgttg 3496621 ctgttccgac agtgctcatt gcagggccgt tatttacaaa gttcgcgaaa aaaatcgttc 3496681 ctgcatcatt tgcgaaaaac ggcaatattg catcactcgg cacacaaaaa acatttaacc 3496741 ttgaagaaac acccggcttt ggaatcagtg tctttactgc aatgctcccg attatcatca 3496801 tgtcggtcgc gaccattatc gacctgcttc aagaaacaat cgggtttgca gataacggag 3496861 ttttagcttt tatcagattg attggaaacg catcgactgc tatgattatt tcgttattgg 3496921 tcgcagtcta tacaatgggc atcaagcgca acattccagt caaaaccgtg atggattctt 3496981 gttcaactgc catttcacaa atcggcatga tgcttttgat catcggagga ggcggcgcct 3497041 tcaaacaagt gctgatcaac ggcggtgtcg gcgattacgt agcagactta ttcaaaggaa 3497101 cggcattatc gccaatcatt ctggcatggc tcatcgcagc gatcctgcgc atttctctag 3497161 gatcggcgac tgttgccgca ctaagcacaa caggtctggt cattccgtta ttgggccatt 3497221 ctgatgttaa cctggcgtta gtcgtactcg caacaggagc cggaagtgtc atcgcttcac 3497281 acgtcaatga cgccggcttc tggatgttca aggaatactt cggattaagc atgaaagaaa 3497341 cattcgccac atggacattg ctggaaacca ttatttccgt tgctggactg ggattcattt 3497401 tattgttaag tttagttgta tgaaattaag aaggagctgt aacacatgtt caattcgatt 3497461 ggtgtcatag gcttaggcgt aatgggaagc aacatcgcct taaacatggc aaataaaggc 3497521 gaaaacgtcg ctgtctataa ttacaccaga gatttaacgg accagcttat ccaaaagctg 3497581 gatggacaat ctctcagccc gtattacgag cttgaggact ttgttcaatc gttagaaaaa 3497641 ccaagaaaaa tctttttgat ggtcacagcg ggaaaacccg tagattccgt catccaatca 3497701 ttaaagcctt tgcttgaaga aggcgacgtc atcatggacg gaggaaactc ccactatgaa 3497761 gacacagaaa gaagatatga cgagctgaag gaaaaaggga tcggctacct gggagtcggc 3497821 atttccggcg gtgaagtcgg tgcgttaaca gggccttcca tcatgccggg cggagatcgc 3497881 gacgtctatg agaaagccgc tcctatcctg acgaaaatcg cagcccaagt cggagatgac 3497941 ccttgctgtg tctatatcgg accaaaaggg gcagggcact ttacaaaaat ggtgcacaac 3498001 ggcattgaat atgccgacat gcagctgatt gcagaagctt atacgtttct aagagaaacg 3498061 cttcgtctgc cgctagatga aattgcatct atttttgaaa catggaatca aggtgagctg 3498121 aaaagctatt taatagagat tacagctgag attttacgca aaaaagacga aaaaacagga 3498181 cagcctctga tcgatgtcat ccttgataaa accggccaaa aaggcaccgg aaaatggacg 3498241 agcatgcagg cgattgataa cggcatcccg tccacgatca tcacagagtc cttgttcgcc 3498301 cgctacttgt catctttaaa agaagaacgg atggcagctc aagatgtatt agcaggcccg 3498361 gaagccgaag aaaaacactt ggataaagac acttggattg aatacgtcag acaggctctt 3498421 tacatgggga aagtatgcgc ctatgcacaa ggctttgccc aatataagat gtcatctgag 3498481 ctttacggct ggaatctgcc gctcaaagac atcgccttga ttttccgagg cggctgcatc 3498541 atccgcgctg atttcctaaa cgtgatcagc gaagcattca gtgagcagcc aaatctggct 3498601 aacctgctga tcgcgcctta tttcacagat aagctccatg cctatcaaac aggcctgcga 3498661 aaagtcgttt gcgagggtat cagcaccgga atctctttcc catgcttaac taccgcgctc 3498721 tcttattacg acggctaccg cacagggcgt tccaatgcga acctcttgca ggcacagcgc 3498781 gattactttg gcgctcacac gtacgaacgg actgatatgg acggcgtctt ccatacgaat 3498841 tggtctgaat aacctgtatt aaaaacacgg tcagtttcaa ctgaaccgtg tttttttctt 3498901 ctatcccaaa caacagaaga cataagttat gttttaaata tcataaacag tgatacaata 3498961 atagctagaa acaatcccca agatcatcat gtgacagcag attgctgttc cgttctattc 3499021 tgcttttggc cattgtcctt tgcccttgac catggtgtca taaaatgttc aaatgccaaa 3499081 acggcctggc attctgattt acaaaagtcc ctgaaaacct tatctaattg agaatcagcc 3499141 tctcatttat tataaaagaa atgcctaaat cctacctgtc acacctttat taagatgaaa 3499201 aaaagtaggt tatggcttga caaaaaatat atattaatta ataattcata tataattaga 3499261 attattattg aaagcgatta tgctttctaa tacattttta ggaggaatat acattatgtc 3499321 tttaatcggt aaagaagtac ttccattcga agcaaaagca ttcaaaaacg gtgaattcat 3499381 cgatgtaaca aacgaagatt tgaaaggcca atggagcgta ttctgcttct acccagcaga 3499441 tttctctttc gtatgcccaa ctgagcttga agatcttcaa gaacaatatg ctgcacttaa 3499501 agaattaggt gttgaagtat actctgtttc tacagatact cacttcgtac acaaaggctg 3499561 gcatgacagc tctgaaaaaa tcagcaaaat cacttacgca atgatcggtg acccatctca 3499621 aacgatctct cgcaacttcg atgttcttga cgaagaaact ggccttgctg accgcggaac 3499681 attcatcatc gatccagacg gcgttatcca aactgttgaa atcaatgcag gcggtatcgg 3499741 ccgtgacgca agcaaccttg taaacaaagt aaaagcagct caatacgttc gtcaaaaccc 3499801 aggtgaagtt tgcccggcta aatgggaaga aggcggcgaa actcttacac ctagccttga 3499861 tctagtaggt aaaatctaag gagtgcattc aattggtact tgatgcaaat atcaaagcac 3499921 aattaaatca atatatgcag ctaattgaga atgacattgt tctcaaagtt agcgcaggcg 3499981 aagatgacac ttctaaggac atgctggctc tcgttgatga gctggcttcc atgtcatcga 3500041 aaatttcagt tgaaaaagct gaattaaaca gaacgccgag cttcagtgtc aatcgtgtcg 3500101 gagaagacac tggcgtgact ttcgccggta tccctctggg ccacgaattc acatcattag 3500161 tgttggcgtt gctccaagtg agcggcagac cgcctaaggt agaccaaaaa gtcattgatc 3500221 aggtgaagaa gatcagtggt gaataccact tcgaatctta tatcagcctg acatgccaca 3500281 actgtcctga tgttgtacaa gctttaaaca tgatgagcgt gctgaacccg aacattacgc 3500341 acacgatgat tgacggtgca gcatacaaag cagaagttga aagcaaaaac atcatggcag 3500401 tgccgaccgt ttacctgaat ggcgaatcct tcggaagcgg ccgtatgacg cttgaagaaa 3500461 ttcttgcgaa aatgggcagc ggcacagatg catctgagtt tgctgacaaa gagccgtttg 3500521 acgttcttgt ggtcggaggc ggacctgctg gtgcaagtgc agcgatctac actgcacgta 3500581 aaggcatccg aactggtgtt gtcgctgagc gcttcggcgg acaggttctc gacaccatga 3500641 gcatcgaaaa cttcatcagc gtcaaagcga cggaaggacc gaagctagcg gcaagtcttg 3500701 aagagcatgt gaaggaatat gatattgatg tcatgaacct tcagcgtgcg aaacgccttg 3500761 agaagaaaga tctgttcgaa cttgaactcg aaaacggcgc tgtcctgaaa agtaaaacag 3500821 tgatcctttc aacaggtgca cgctggcgca atgtcaacgt ccccggtgaa caagagttca 3500881 aaaacaaagg tgtcgcatac tgcccgcact gtgatgggcc attgtttgaa ggcaaagacg 3500941 ttgcggtaat cggcggcgga aactctggta tcgaagcagc gattgatctt gcaggtattg 3501001 tcaatcacgt tactgtacta gaattcgcgc cggaactgaa agcagacgaa gtcctgcaaa 3501061 aacgtctcta cagcctgcct aacgttactg tcgtgaaaaa cgcacaaaca aaagaaatca 3501121 caggtgatca gagtgttaac ggcatcacat atgtagaccg cgaaacaggc gaagaaaaac 3501181 acgttgaact tcaaggtgta ttcgtccaaa tcggtctcgt gccaaacaca gaatggttag 3501241 aaggaacggt tgaacgcaac cgcatgggcg aaattattgt cgacaaacac ggcgcaacaa 3501301 gcgtaccagg cttatttgct gccggcgact gcacagacag tgcgtacaac caaattatta 3501361 tttctatggg atcaggtgca actgccgccc tcggcgcgtt tgattaccta atccgtaact 3501421 aatataagaa atccgctata ttgccagatt ggcaggatag cggatttttc tttttctaca 3501481 gaaaaaaacc gaaccaggca ctacggtaaa agtgctcgat tcgagcgctt cttatagttc 3501541 ctcaccattc gtttgaatga catttttata ccactcaaag gagtctttct tatatcgttt 3501601 catggatccg tttccttcat tgtcacgatc aacatagatc atgccgtagc gttttttcat 3501661 ttcgccagtt gtgaaggaga caatatcaat aatgccccac ggcgtgtagc caattaaatc 3501721 aacaccatcg tacgtgaccg cttttttcaa tgcttcaata tgcgatttta aatattgaat 3501781 gcgttccgga tcatgaacct tgccgtcctc ctccagcgta tccactgcgc caaagccatt 3501841 ttcaacgatg aataacggga tttggtatcg gtcataaaaa cgatttaacg tatatctcaa 3501901 cccggttgga tcaatcgccc atccccagtc actcgaagtg atgtacggat tttcgacacc 3501961 attcggcaag ccgccattta caatatcgcc agtgttatca tttttcacat cgcttttcac 3502021 agttgttgac atgtaatagc tgaagcctaa gtaatcgacg gttccgtttc ttaaaatctc 3502081 atcatcgccg tcttcgaatg tgatgttgta gccttcgcgt tcaaattcct tcaacgcgta 3502141 gcttggataa taaccgcgaa cctgcacatc agggaagaaa tagcgctgcc tcatttcttc 3502201 ttcagccagc atcacatctt caggattgga ggagaaagga taaatcggca cgtgtgatac 3502261 catggcccca atctggaact ctggattgat gtcttttcct tttgccactg ctaaggcgct 3502321 cgccactaat tcatggtgcg ccgtttgata catgacttcc ttggcgtttt cgttttcgcc 3502381 aaccacaaca cctgaattcg tccataggaa cagcggattg ttcacatcca tttggttgtt 3502441 aatctcgtta aatgtcatcc agtacttcac tttatctttg taacgggtaa agcaagcctc 3502501 tgcgaagttg acgaagaagt ccacgacttt ccggtttctg aagccgccat attctcttgc 3502561 caggtgcagc ggcatttcaa agtgagacag ggtaatgacc ggctcgatcc catgcttcag 3502621 caattcatca aacacatcat cataaaactg caaaccagct tcgttcggtt cagcctcatc 3502681 gcctttcgga aaaatccggc tccagccgat ggacgtccgc agacatttta atcccatttc 3502741 cgcaaacaaa gcgatatctt ccttgtatct gtgatagaaa tcaatggctt catggtttgg 3502801 ataaaattcg ttttcttcaa tcgtgtcagt gatttttctc ggcacgccgt gcgcacccgc 3502861 tgtcatcaca tcgacgacac tcggcccttt accgccttga ttccatccgc cttcaaattg 3502921 gtgggcagct aaagcaccgc cccataaaaa atcctttggc atgtttccca tgtttaattc 3502981 ctcctcagct tacgactgta aatatttttt gatgtaatgc actttcctca atgtcttcaa 3503041 tgaaagcttt atcaaactca acaagcactt cgcctttttt gacggtatcg ccttctttta 3503101 ccttcaagga aaaaggcgtg ccgtcaaatg tcaccgtatc cagcccgatg tgcgcaagca 3503161 attcgacgcc ggacgctgaa cgcaggccaa tcgcatgctt tgtaggcgta accatgacaa 3503221 ccgtaatgac gccgggatgg tagcatcgat ttcacgatat ccttcgcttt aggggtagac 3503281 cgcttcagca ccaatcgaag tctggtagcg cagcgagaag ccccaatcac attctcttcc 3503341 ccgcctacgg cctctaaaat gtcttttgct agtctcgtat aatctctcac tttccccgac 3503401 atttcaccca ccccttcgtt ttggttacgc tttcattata attgtaacgg tataatttat 3503461 caattccgaa acaaaatatt tacgcactaa ctatcattgt aagcggttta tgctataatt 3503521 ttgacaagtg aaactaaacg aataaatgag gaatgcgtat gttaaaatac cagcaaatcg 3503581 caacggaaat tgaaacatat atagaagaac accagcttca gcagggagac aaactgccag 3503641 tcctagaaac cctcatggcc cagtttgaag tcagcaaaag caccatcaca aagtccctcg 3503701 agctattaga gcaaaaaggc gcgatctttc aggtcagagg aagcggcatt ttcgtcagaa 3503761 aacataaacg aaaaggctat atcagccttc tgtcgaatca gggatttaaa aaagatctcg 3503821 aggatttcaa cgtcacctca aaagtcatcg aactggacgt gagaaagcca acaccggaag 3503881 cggcggaaaa cctgaacatc ggaatggacg aggacatcta ctatgtcaaa agggtccgct 3503941 acatcaacgg ccagaccctt tgctacgaag aatcctatta caccaaatcc atcgtgacgt 3504001 atttaaacaa cgaaatcgtc tcccactcca tcttccatta catccgggaa ggactggggt 3504061 tgaagattgg tttttctgat ttgtttctgc acgtgggcca gcttaatgag gaagaagcgg 3504121 aatatttggg attagaggct ggactgccga agctgtatat agaaagtatt tttcacctga 3504181 caaatgggca gccgtttgat tactcgaaga tttcgtataa ttatgagcag tcgcagtttg 3504241 tggtacaggc taatagtttt ttattatagg gctcttcact acggtaggtg gtcgacatgt 3504301 acaaaattat cattcctgcc atactagcca tctttgcgct ctggatactc ttacagattt 3504361 cactagagat gagcatcgtt aagaatccaa tgaactactt tatcgtattc attatctttt 3504421 tcctctttgt aaagatggtg aaagaaaaac aataatagtt tgggcgatgc aaacagaaaa 3504481 acatccttcc cttaacaaac tcagccagtc acatgcatta atcttgatgt taatgatata 3504541 taggtgcaca taaaaagcta cttcattgtg aagtagctcc ctttattaaa ggcccatttt 3504601 gatccatcta gttttagaaa agcgaaggac aatcgcattt atgataataa ttgaaactaa 3504661 atacaaaata ataaataaaa catcattact cccaagtgtc atgttatcag attgcagcac 3504721 tctttctatt cgggggtaca tagtgttacc tgcctcaaaa ggagcaatga aaccaaacgt 3504781 tttattgctt atagctacta agataacaga agtcatccaa taaacgatac tgacacctat 3504841 actaattaat atattaggac ataacacgct tatagttccg ataattagaa tatactgcag 3504901 tataactgca gaaaataaaa aaagtaataa tgcaaaatgc gaaaaatcat ggtacatcaa 3504961 cgatatgatt agcaggccta gcgttataaa tgcaaaacat tctaaaaata aaacagctat 3505021 ctttttataa aagaaagtat agatgttctc tccaattaac ttgtaaaaga gaatattttt 3505081 gtttgaatac tctctattaa taaagaaagc tataacaaat gaaaataaca tcaaaccaaa 3505141 ctgggtcgca acagtatagg agctaaagaa aaacatttca ggtgtaacat tactgacttt 3505201 atcgattcca acaagtaaaa aataacccag caaaaataaa aatacaaaca ttgctcctaa 3505261 aataatgata actttgttgc taatactctt tttaaactct aatttcatct caagccccca 3505321 ctgttttatt actcatttat atacacttca attaatttat ccactgaatg atattgttga 3505381 atttcttggt gattaaatat ataataatcc ccttctatcg cctttaaatc agacaaatca 3505441 tgtgtaatgt tgatgataat cttctcgggg ttctcctgaa tatacttgtt taagaagcca 3505501 tgaatctcta taaccgtttt tttgtctaat gaattcgtta tttcatctaa aacaataata 3505561 tttttatcct ctaataagaa actgagcaat tttaattttt gcttttgtcc atcactcaaa 3505621 tttttgatca gaacttttcc atcaatatta tccagattaa gtaaatatgc gattttatct 3505681 atcatttttg catcaaattt tttactcaaa aagtgtaata aaaagtcctt agaaacatca 3505741 ttaggtatat tcgacgagct ggatattaaa gaaacatttt gacgaatatc tctgccgatt 3505801 cttttgctat tattcaacaa aaagtcttta gcaagctgtg atttaccgac tccatttttt 3505861 ccgacaacgt gattaatttt cccgctcgaa aaatgcaagt cggtgtcctg aagtaacgtt 3505921 ttgcctttca cttttaaagt gtaattcgct atattcatat acatactcct aggaaatatt 3505981 tgcataataa taaaatgttc tgccttgtga tttgttacta atgtctaagc ttttgaggta 3506041 cctctttcgt ttccgatccg gaagcgaaag aaatgttttt agatggctaa tttggagatc 3506101 ttttactcta gtttacaata tataatatcc aatgtacaac tgaattcact gcaaggccaa 3506161 tccctataat ttgaatcgta agaactaacc aatgatttgt cttaaaacgg ctatattcat 3506221 ctaagctcag aaaagctaaa agaattttgt aaccatcaga attcaatatt gggattaagt 3506281 tccacaataa agtagacgag aaaagcataa atgccatagt taatgcttca ctggaaaatg 3506341 taaattgatt tattaattct aatgtattta ttaaaagata attgataaac aagccaaata 3506401 aatgaacgat tatcttttca tttcttgata gcatgtaggt ttcattcaat tggacataaa 3506461 aagcaggaaa tacataaaaa ttcagtttga atcccacttt atcaaagttt ttcccgaaaa 3506521 attttaagga ataaatatgt cccagttcat gaagcactat attcattata aaataaataa 3506581 ctataattat ccacattttc cagccgtaaa atactgagga caatccattt tgcaatttta 3506641 ttaaatgaat ataatttaat atgaacatga gagccgtaaa ggataagaac agataaaaaa 3506701 actttggtga tactttctct ttatacattt taaaacgtaa taattgttta tctgacagag 3506761 aatttaaact atttttatag tattctccgc tttttttgtc ttttataaat acgttgtttt 3506821 gcacaagcac ttcatatttt tcatcttcat actttaaaat tttcattata gtatttttcc 3506881 atataaggat agaagtagtt tattttttct gcagagttga ataaggaacc acaaactcca 3506941 caaatagagg aaaattcata aggaatgtca aattcctcta ttttgttatt ttcttttaaa 3507001 atattcaaaa accatttgaa tccttctttt ctaagaataa ataatagcaa attggaattt 3507061 aacttttcca cggttctttc gaaactttgg ttatattctt cccttagggt tattttcgtt 3507121 tcaaaaatag caggggaaca acatggataa atttctccat catgatgata tacaatgtca 3507181 tatccgggac aatgtaagga atcttcatct tcaagactgt aaaatttatg tatgttttct 3507241 tgcttaattc tagttttagc agcgccaact gatatcattg gaaattttgt tatctttaca 3507301 cctaagattg aatcccccaa ttcctctaaa atgtggttgg acattttgtc tttggtaact 3507361 gccatattaa gagaaatatc gatatcaggg tatttcctgc tatgttctaa tatgttttta 3507421 atactggaag acttgacaaa tggagcatgg tactcatcat aacttatagt cagtgctatc 3507481 acatttaaag aattcatatc atgaaagtac tcctggacct ttttcttgct caaaccccaa 3507541 aatccattag agatcaacgt tatttgtttt tcatatggtt taatgatttc cattagttct 3507601 tttaaaaatt tataatctaa aaaaacttcc ccacctgtaa aagaaatcac ttgaatggtt 3507661 ttgttttttg caaattcagt tactaactct cttatgtatt ctttttccat cctggttgtt 3507721 gaagttggtg aactagaaaa acaacaatgg tcacaggatg cattacacct tgaatctaaa 3507781 ttgattgata ctgttttatt atacatgaaa tatcccccaa caaatggtaa aggagagtta 3507841 gactctcctt tgtacccctc taattaatga ccacttccaa gaatccagcg attttctttt 3507901 gattttacaa aataccaaag atcattcact tttgctaact tttgtgattc atctaataga 3507961 cccttaaatt ctaagttttt cacagtctca ttgttagtga tttccttttt catattatcc 3508021 ctcctccttt tctaatataa accaattatt ctatatcatt caatacatgt caatatattg 3508081 tacctaaaaa atctgaaaaa tgtcactatt cttggtatat aaagcctata gtcctctagc 3508141 ccctctaagc tataccgaat gaaaggccat agtttgattt aaagcttcgt aatgaaaagt 3508201 aaaacatcaa tattgactac actagttaag ggatatacag attttaagtg gaagaaatga 3508261 ggcaaacaat cttaccctaa accaacctgt actgaaaagc tgttttaagc tcttgcttac 3508321 cccatttggc acctctttct ctcgttttaa ttgtctctaa aagcagttat gcggtactat 3508381 catataaagg tccaatgttt aaaaataatg tcatactttt aaattcacct tatcatgcac 3508441 atgctcataa agaggggttt attctaaaaa ggggatggac ggttttggaa agcaagtacc 3508501 tagatctact cgcacaaaaa tacgattgtg aagaaaaagt ggtaacagaa atcatcaatt 3508561 tgaaagcgat attgaacctg ccaaaaggca ccgagcattt tgtcagtgat ctgcacggag 3508621 agtatcaggc attccagcac gtgttgcgca atggttcagg acgagtcaaa gagaagatac 3508681 gcgacatctt cagcggtgtc atttacgata gagaaattga tgaattagca gcattggtct 3508741 attatccgga agacaaactg aaattaatca aacatgactt tgatgcgaaa gaagcgttaa 3508801 acgagtggta taaagaaacg attcatcgaa tgattaagct cgtttcatat tgctcctcta 3508861 agtatacccg ctccaaatta cgcaaagcac tgcctgccca atttgcttat attacggagg 3508921 agctgttata caaaacagaa caagctggca acaaggagca atattactcc gaaatcattg 3508981 atcagatcat tgaacttggc caagccgata agctgatcac cggccttgct tacagcgttc 3509041 agcgattggt ggtcgaccat ctgcatgtgg tcggcgatat ttatgaccgc ggcccgcagc 3509101 cggatagaat tatggaagaa ctgatcaact atcattctgt cgatattcag tggggaaatc 3509161 acgatgtcct ttggatcggc gcctattccg gttccaaagt gtgcctggcc aatattatcc 3509221 gcatctgtgc ccgctacgac aacctggata ttattgagga cgtgtacggc atcaacctga 3509281 gaccgctgct gaacctggcc gaaaaatatt atgatgataa tccagcgttc cgtccaaaag 3509341 cagacgaaaa caggccagag gatgagatta agcaaatcac aaaaatccat caagcgattg 3509401 ccatgatcca attcaagctt gagagcccga ttatcaagag acggccgaac tttaatatgg 3509461 aagagcggct gttattagag aaaatagact atgacaaaaa tgaaatcacg ctgaacggaa 3509521 aaacatatca actggaaaac acctgctttg cgacgattaa tccggagcag ccagatcagc 3509581 tattagaaga agaagcagaa gtcatagaca agctgctatt ctctgtccag cattccgaaa 3509641 agctgggccg ccatatgaat tttatgatga aaaaaggcag cctttattta aaatataacg 3509701 gcaacctgtt gattcacggc tgtattccag ttgatgaaaa cggcaatatg gaaacgatga 3509761 tgattgagga taaaccgtat gcgggccgtg agctgctcga tgtatttgaa cgattcttgc 3509821 gggaagcctt tgcccacccg gaagaaaccg atgacctggc gacagatatg gcttggtatt 3509881 tatggacagg cgaatactcc tccctcttcg gaaaacgcgc catgacgaca tttgagcgct 3509941 atttcatcaa agagaaggaa acgcataaag agaagaaaaa cccgtattat tatttacgag 3510001 aagacgaggc aacctgccga aacatcctgg cagaattcgg cctcaatcca gatcacggcc 3510061 atatcatcaa cggccataca cctgtaaaag aaatcgaagg agaagaccca atcaaagcaa 3510121 acggaaaaat gatcgtcatc gacggcggct tctccaaagc ctaccaatcc acaacaggca 3510181 tcgccggcta cacgctgcta tacaactcct acggcatgca gctcgtcgcc cataaacact 3510241 tcaattccaa ggcagaagtc ctaagcaccg gaaccgacgt cttaacggtc aaacgattag 3510301 tggacaaaga gcttgagcgg aagaaagtga aggaaacgaa tgtgggtgag gaattgttgc 3510361 aggaagttgc gattttagag agtttgcggg agtatcggta tatgaagtga ggggtgtggg 3510421 gttcagggat ggtgatatgc tgctccccta aaagtagata gatgaatttt agaaaatctg 3510481 tttgccttgg ggagtttttt catggctgga caattatact acaaggaaga aatactaata 3510541 cttatagaat gtaattgggt aatgattcgg agaaagaggt tgcgaaataa tatggtatta 3510601 cactgaaaca attatcaatg gagaacatgc acgatatagc cgttctatat tctccctcta 3510661 ttatggcact cattagtaga cataaccgta aaaaaatgca ctcaaaaaaa gtccattcta 3510721 tataactctc gctagggtgg acctttttca acattcaaag tactagattt tttctagtga 3510781 aagaataaga aaagacataa gttctatttt atcactctgt tataggttaa gttattacgg 3510841 tgtttcatta tatactgaat ttaaacaccc ttgacattat gggaattttt aaaacaggtt 3510901 aaaaggaagt tctataagaa ctccctagtt taatattatt tggtcaaaat ctaaaaccaa 3510961 aaaatctatt tttatcttca ttgtttctat ctaattttgc aacaatcata cctttcgact 3511021 ctaattcttg aaggtcatct aataataatt catttttatt tattgttaca aaatattgtc 3511081 cgatcctatt ctctaacaga cttgaattga tatgttttaa taatgtacct tttacatgag 3511141 gatcaggatt agaataagat ccgtcatgaa ttaaaatatt caaactacac ttatttatac 3511201 acctgtataa aaaccaagta agatcaaata tatttatctt catatggagt ctaccatgtg 3511261 aacgttcatc cggtatagaa caagaaattt tgatccttcc tgtagttgat tgttttgcgt 3511321 tacttattct attatcatat tcaaaatcta aaaatccatg ttggttgtat gtaacatcca 3511381 ttagattatt aaaaagcttc tttaactcac taactatagc gctataagat tgaaactcat 3511441 cataatacat tgaattaact cttaatattt catgttgaag ttcattaatc ttatcaaaaa 3511501 tatggttttt tttatcgtag tcactaattc tcaatcttac ttccgctaac tctatttctt 3511561 tccttctttg ttcttccatc acaatggaaa tatcctcaat gaaattgtta ctctttaaaa 3511621 ttctggcact tgattccagt tgttctgtta atccttgctt tttgatatta agttttttta 3511681 aatcggcttg tattttaaca attttatctt taaaataact ccctctactt tctaccatga 3511741 aattatagaa ctcttggact ttattataat tctgttttac ttcctctgga aaaaaaccta 3511801 caatatcttc atagaatttt tctatatttt ctaattcttt aatcttagtt acttttttat 3511861 ttaaatcatc tatatttctt tgatattgtt tacaaatatg ttcattttca aatatttcat 3511921 tttgtatttt attaagttca cttttaattt ctgagtacct atttgtatca ttattatatt 3511981 tattggcagt cttagtttga tagataactc tattgtaatc ctctatctca tttattaatt 3512041 catcttcctt aacttttaaa tcgccaatgt taatattcat tgattcaatc aattttattt 3512101 cactatttaa tttttcaatc ttatcccgaa aaacctttat gtttttttct gtatgagttg 3512161 gtaaagtaaa aagatagtta agtaatttat attgttttaa ccctccccta ttcggtaaaa 3512221 ctatatcatt aaaccctgtc ttttcgtctc ttataatata ctcccttaac gccgcaaaag 3512281 ttatatcctc tttctcaccc tttaaaattt ccttttcaat aaatttttta tatacactta 3512341 tactaacttt tttccattcc tccaaattaa aagttaaaga agtatcatgt aatgtataac 3512401 catgtttagg agaattaaaa gatctagcaa ggaatacttg atttccatca atttccacat 3512461 tcaaaacaat aaaaacgttt ttattgagaa gaatttcatt tgtcgtataa aaatttgata 3512521 tagtcttccc tagtaaaaag gagatgcatt caatcatcgt tgacttacct acaccattag 3512581 tctcttcatg atcttctctc ttttcaccaa gtattatatt tactcctaca gcattaaatt 3512641 tatactcttt caaaatttct tgggaattgc aaacaaaaag attttttata atcataacaa 3512701 tcactaactc tccgttctgc taatcatatt ttgattaaaa gaaactttac ctaatgaata 3512761 taaaaaagtt aacgataaat acagtatccg ttcaatattc aaatttatta taataccttg 3512821 actcttagca taatcaagaa aaagttgatc aatatgtttt tccttctcta acagttcata 3512881 aagtatcttt gatgagtata aaatattttc ttccacagca ttatatttag ttaataaaaa 3512941 atgattcatt tctggcctct ccgccttttc cttttttaaa ggagaattat tcactagagg 3513001 aataagatca tttccaattt gaatgttttt aaactcattt tctaataaaa cataagagta 3513061 tttgagaata ttttcagctg tttcaatttt aagatcaatc attcttaaca cttcttttgt 3513121 tatcattaaa aatctcacat tcataaatgc accaacatgt taaaatctta atgtattttt 3513181 tcgttaaagc ctttgaatat ggtaaaactg aatgacattc tagataaatc tcattaacaa 3513241 tttttacaaa tatctcatct ccattattat attgattatg aaactctaga tatttgtcta 3513301 ctatcgtctc agcaatcaat tcctttttat cagcacttac atacgaagtg gaatccatta 3513361 tatggtttat cacaccaaaa tactcagaat aactatcgaa tttccgttta aaagtttccc 3513421 cacttttcat atcataaaat tttttatcta aaccaatttg attatcaaaa ttactagtaa 3513481 atgttttata actttctcta tactcatgaa aatctataat aaagctctta aactcatctt 3513541 catcaatttt atcatcgtta tcttctattt ctttttcaat aaggctctct aatctattaa 3513601 tcttataatt taacttccct tcctgtagtc tccttcctcc ttggttgttt tttgaccagt 3513661 atttatattc ggtattccaa atgtagtatg ttacttctgt ctcgccatta tctaaattca 3513721 catccaccga aataaattct ggagtagcat actcatcctt tataatggct ccacttacta 3513781 attctaagaa tggattttca tttgtatttg cagtaatatt aaatgaagaa tcatgtacat 3513841 gtcctgccaa atatagatca ataaagtaat catcaaaatg tgcctttatt gattctcttt 3513901 cggaagattc aatacaacct aacgtatggt gcccaatagc tatatttaat accttgccct 3513961 tatttttctc tttgttcatc ttccttattg ctttatataa tttcatctgt gcagttaata 3514021 acgttccttc ttcacctttt ttatctgata acagacatgt atttattgat aaaacattat 3514081 acttctccga ttgatacaaa aaatgcaaat cttcttccgg atatttaaca cccataaaat 3514141 cttcataaaa atcgaaaaat ttcctttgac cttccactaa tatatttgta gctttttgat 3514201 ctagtttatc caacatttct gaggggttag gagatttcat aatactatca atcaaaagtg 3514261 tcctcgtcat gtctctagat atatcgtgat ttcctggcac taagtgtacg ttattcttac 3514321 ttaatcccat acttttaata attccattaa gatattcttt aacatcttcg ttatacacat 3514381 cacctttgtg tgctatatct ccagttaata ataaaaaatc aaaatctgac tctcttctta 3514441 aaacttctat aaaatctaat aatttatctc tcattacaat agtgtcataa ttttgaaact 3514501 gaaaatgcaa atcagaaatt tgtaaaaaac gtaccttcaa tacaaacatc ctctcataag 3514561 tatatttatc ccctatatat ttctagaaaa ctttttattc tatatcatct ttactcttta 3514621 atatattaag actctttcca caccatcaaa taaattataa cctaaacata actctttact 3514681 cattttagta ttgtatttaa gtcaaacatt gcattggttg ctgaaatatt atattcattg 3514741 aattattcca ttaaatagct tttagttgaa ctttagtctt tctgtaatgg tggagatgct 3514801 cttacttatg ataaggctcc ccacgattaa tccgaaaagc ccgataaatc tgctccacta 3514861 aaataagccg catcaactga tgaggaaatg tcatcttcga gaacgatagc ttctcgtccg 3514921 ctcgcttcat caccgtgtca ctcaatccga gtgatccgcc gatgacgaag gtgactttgc 3514981 tttttccata agtagccagc ttatctattg tatcggctag ttcttcggat gttttcattt 3515041 ttccttcgat ggcgagggcg atgacgtggg cgtcggggct gattttggat aggatgcggt 3515101 cgccttcttt gtcttttatg attttcatgt cctggtcgct taggttttcc ggcgcttttt 3515161 cgtccgggag ttcgatgatg tcgatttttg cgtaggccga aagtcgtttg gtgtattctt 3515221 caatgccttg cttgaggtat ttttctttta gttttccgat tgtcacaata ttgatattca 3515281 caggtcatcc ccactttaaa aacaagttat tcatatatgt tgtccacaat tgtggatatc 3515341 ttttctgtat tttgtgtaag atcattcgtt ccccactata tatactgcgg ggtctccaca 3515401 taattcacag gctgtggata aactgttagt atgttcgatt tttctgattt cgggcggcag 3515461 ctcgtggtcg tctatgtaca tatccagcac cgtttcgatg tgttcttcac aagaataata 3515521 cgcttgtttc atgttcaaat cctccgatgt tttcttccat ttttacaaat gttctcttct 3515581 caatataacc tatttattca catgttagta gtgcttcggg ctgagtttta tccacaattc 3515641 gacaaacaag ctgttgatga ctctatttcg ctcgtgtgtt agtttggatg taaccgatgt 3515701 gtggggaggt ctgcatttgc gctttagatg ggtttggctt tttgtgatta tgttgctgct 3515761 tgctgagtgt cagccatctt attgggtgtt ggagaaggat cgaatcggtg aaggcagtcc 3515821 agacttagaa atatacgcta attatctcca aatgcatgat gacgtgaaag gatatcaagt 3515881 cttcaccata tcagaaggca aaaaaatggt cgtcgtgtct ctcggaagca gcgagaaaga 3515941 taagaagctt gaagtgtcgg acgtcaaatt ctcatctaaa gaaacgattg taactgtgga 3516001 gcgaaaacct gctcctacgg caaatgagaa aaaccctttt attttgattg gactggacaa 3516061 aattgaaggg gatttaattg ttcaagacga aacaggagat cgctttgaag aaacggatta 3516121 ccagcaataa agccggcgtt ctgagaacgt ccggcttttt cttttacttc aatgtcccat 3516181 gcgggtcgat gacgaatttt ttggctgcgc ctttgtcgaa gtcgctgtag ccttttggcg 3516241 cgtcgtccag agaaataacg gtggcattga cggcttttgc gatctgcgct ctgccgctca 3516301 ggatcgcttt catcaaattg cggttgtatg tcatggcggg cgtttgtccg gtgacgaagg 3516361 tgtgggcttt ggcccagccg agtccgaagc ggatttttaa tgagcctgtt ttggcgtccg 3516421 catcctttgc accgggatct tcggtcacgt ataagcctgg aatgccaagg ctgcctccga 3516481 cctgggtgac gtccatgatt gagttcagca cggcggctgg cgcttctcct tgattgccgt 3516541 gcccagatgc ttcaaagccg acacagtcca ctgcagcatc aacggttggt tcacctagta 3516601 tttgttcaat ttgctcgccg aggcggtcgt gtttttgcac gttgaccgtt tcacagccga 3516661 agcttctggc ctgtgccagc ctgtcttcgt tcagatcgcc gacaatcacg gtagaggcgc 3516721 ctaggagctg agcggagtgt gcagctgcca agccgacagg acccgctcca gcgatataaa 3516781 cggttgaacc tgtttgcacg cccgctgtat aagctccatg gaagccggtc ggaaaaatgt 3516841 cggacagcat ggtcaaatcg agaatctttt ctagcgcctg ttctttatca gggaatacca 3516901 aaagctgaaa atcagcgtat ggcaccatga catattcaga ctggccgccg acccagccgc 3516961 ccatatcgac gtagccgtaa gccgatcccg gccggtccgg attgacattc aggcacacat 3517021 gcgttttctg cgttttgcac atcacacagc gtccgcaggc aatattgaaa ggaacggata 3517081 cgatatctcc ttttttgata aattcaacat cacgccccgt ttcaatgact tctcccgtaa 3517141 tttcatgccc gagcaccaag ccttctggcg ccgttgtgcg gcctctgacc atatgctggt 3517201 cgcttccgca aatgttggtt gtaatgactt tgagaataac cccatgctca cattttcgat 3517261 tcacattcgc cttcgggacg ccgggcccgt ccctcaagat taactccgga taaccgatat 3517321 cctccaccgc tacagtccct ttgcctttgt acacaaccgc tttgtttcct gtcaacgcca 3517381 ttcctcccat tcatgtgttt ggactctccg tccttgaaca tgacttcggt tcggcatgac 3517441 tctttccctt tttcacgact gttttttctg tattcttaca acaacaaata tgccaagaaa 3517501 gcatccaata atggttccgc cgatgtctaa gaagtcgact ttacatccat ttaacaagaa 3517561 cacagtaatg gccgaaacca ggcagatcat aactgccaga agaataaccc gatttgtctg 3517621 catgtaattc ctcctttgga ttcgtttcta aaccataccc aaaatcctct gcaaacttcg 3517681 gttcaacaaa aaaagagact tcacaccagt ctcttcataa acagagatca ctcaaaaaat 3517741 ttcctgagaa ataatgtggc aacactcgtt actaacgcaa ttgccgtata cataacaacc 3517801 caaaatatga atgagctatt ccccgaagct aacgtaacta acaatatcaa gctcgtgata 3517861 agaacgatga gcggtgccac ccaaaatctt ttaaataaaa aatgacccgc tataccaaat 3517921 acacctgcga cgatcggaaa accaaaaacg ataaataaaa cggcgatggc tcccatacta 3517981 ccctccttgc cttaaaacct cttcatcacc tcaacatcat acagcttcaa atgactcttc 3518041 ggcgtcacga catcctttac cttcccaatc tctttttctt tcattttctt tccggttttc 3518101 aggctgtact gttcaatgta ggcaggcttg tgatacgtgt atgtgaagaa atagaggctg 3518161 ctgccttttt gggtgatttc tttgaattcg gctttcattt tgtccgggga aagggtgaag 3518221 acgatgcttg tttttcctgt cttggcatcg attttgtgta cctttccgaa gccgtcaatg 3518281 aaatacaggt tcccgtcata agggaaaaag ctgtttttaa agctgaaggg catggagctg 3518341 tatatcgttt gttcgtcgtt tttgtattcg gcgatatcgt gcagctctac ttcgccgctt 3518401 tttttgttga tcttgaccat ttgatagaga tcgtgggctt tttggccgcg aaccataaca 3518461 tacacagctt ggtcgtccac ggcaagttgg gattcgactg aggctccttc ccggtactgc 3518521 cattccgtta tgctgagata ggtaagcttc ttctgatctg cttgaatctg aaggagctga 3518581 tagccttttc cgtcatctgt cgggacgagt gcgtaaatgg cgccatcatg gaaaccggag 3518641 gctcggatgt agtaggggat gacgtctttt ttccactctc cgtccatttg gcggtacagc 3518701 tctgagcggt atccgtctcc ctttttgtcg tagccggagt tgtataaggt gtaaaagccg 3518761 tccgtgtttt gcagaaagcc cgcgctgtcg cctgtgtgct gataggttct tttatgggag 3518821 cgcaggccgt ttttgatcgt ataaatcgtg tttttgtcct ccagcatcac gctgtcaccg 3518881 tgaacctttg ctgagcccag ctcaaggccc ttcatctgaa aggaagacag cgtcccgtca 3518941 tggctgataa acagggcgta gcttttcccg ccgccaaatg catcttgatc cgcagaggat 3519001 gagaaataca gcaggacttc tttgtcatcc aggaaatcgg gatttctgag atcctgctga 3519061 ctcacggttt tatggctttt gagaggagaa atgaagacaa atagtgcgat tcctgcgaga 3519121 atcagcatgg cgatggtaat catccacttt ttcatagcct tctccttagt aaatggtcat 3519181 aatggttgtc gtataagaag aactagtgat gtcgcgcgga tacacgccta agcctccgtt 3519241 gctgtctata tcaatccctg ctttcagcaa aaaggcagac cataggagct ttgaacagtt 3519301 tttggcgccg tcatggccgg tatttctgtt attgacgaag ttaaatgagt atgggtcgcc 3519361 gacttttgat accgcccagt cggcagcagc tgttttttga gatgaggata cgctgacggt 3519421 ttgcacaatg gagttgtctt ccacgtctct ggcattatac gcgatctgcc tgacgccgtc 3519481 gctcgggaca gattcaacaa ttttgtcagc ggcggagtac atgccgacat ggccgtgatt 3519541 gtagtaggct gtgtaggagt tcgtgtaata gatattgcct ttcgcgcttg tcgggagttt 3519601 tttcgtgccg gacgagccgc ccatgataga catgccgctt tccttggcga gccggtcccc 3519661 ctctgcttta tcagccgtga tctccttata gaactgtttt aggataacgt cctgctttac 3519721 gtgctgctgt ttggcaatct ggctggcaga tttcatgatt tcttccggtg tcgtgcctgg 3519781 ctgcagtgcg gcgatttctt cagcataatt tgtggtcttt acggctttgg cgggagtaac 3519841 aaacaggccg ccgcacattg tgagcgctac caaaaacatc gacactcgtt tcttcaactt 3519901 cattacatct cctcttttct tgtgagtgta ggaaaggtaa tttcctcacc cacattatat 3519961 taggaaaata aggaaagtaa ctaggttatt tacagaattt ttagaaatcg tttacagaaa 3520021 aaggccttta tcaggccctt ttcgttaaag cttcttgctc atcactacgt ctgtttcttg 3520081 aaatccggtt tgctcatata gctttcgagc cgtctgatta tgggcaaaga catgaaggga 3520141 cagcttgcgg attcccatac tgcgtgccgc ttgatctaat gccgccaatg cttgctttgc 3520201 gtagcccttt ccccgatacg gttcatataa cccgaaatca taaataaacg cttcctgctg 3520261 cggatgctcc ggttcagcat gtatccagag ccagccaacg atatcctttt cattcagctt 3520321 gaggctccac aaatggtgat ggggtgtttc gagccctctc ggaagcagat cagtaaacac 3520381 ctgcttagac aaaagctggg catcttcagg cagccatgtt cccgctttta ccttttcttc 3520441 cgcgtaatgc tttgttgtgt acgtgagata agaccgaaat tcttctgtct gcataggggt 3520501 tagcataatt gtcatatcat ctctccttca tatattgact agaggatttt acataaaata 3520561 gaaagaggtg ttactatcag aataagcaac tgagattgat aagtcactag agaaaggagt 3520621 ttcacatgaa taagatcgca cccgcagaaa tcgctagcat gctcaacgat tggtaccttg 3520681 ccatcaagaa acatgaagtt gaagaatcct cccgtttatt tgaagaagtg aagcctttat 3520741 tggatgacat ggaagaggat caggaggtgc ttgcctactt ctccttattg gaactgcgcc 3520801 acaaggtttt gcttcacgag gcgagaggac agggctttca gcatgaggag ccttctcata 3520861 tgaatgctac gtctgacatg ctgaaatatt acttttttct gtttgaaggc atgtatgagg 3520921 cctataaaaa taattatgac attgccattg ggctgtataa agatgcagag cagtatctcg 3520981 acaacattcc cgatccgatt gaaaaagccg aatttcacct gaaggtcggt aagctctatt 3521041 ataagctggg acaaaatatt gtgtccctca atcatacacg gcaagcagtc aaaacattca 3521101 gagaagagac agattataaa aagaagctgg cttcagccct gattaccatg tcaggcaatt 3521161 ttacagagat gagccagttt gaagaagctg aggcttattt ggacgaagca attcggatca 3521221 cgagtgaatt agaggatcat ttttttgaag cccagctttt gcataacttc ggccttctac 3521281 atgcgcaaag cggcaaatca gaagaagcgg tttcgaaatt agaggaggct ctacagaacg 3521341 atgagtatgc ccgctccgcc tattattatc attctgccta cttgctgata cgagagctgt 3521401 ttaagatcaa aaagaaagaa caggccttat cttattacca agacgtgaag gaaaaattga 3521461 ctgctgagcc gaatagaata tgtgaggcaa aaatagacat tttatatgcc atttatgcag 3521521 aagggggtca tgcggaaacg tttcacttat gcaaacaaca tatggatgac ttgttgtccg 3521581 agaaagagta tgacagtgta agagaacttt ccattttggc tggcgaacgg tatagggaac 3521641 ttgagcttta caaagaagct gcccactttt tttatgaagc attacagatt gaagaactga 3521701 ttaaacgaac ggaggttata taaatgaaaa gatttctgat tggcgcaggc gtcgcagcgg 3521761 tgattttatc aggttggttt attgcggacc atcaaaccca ctcacaggaa atgaaagtcg 3521821 ctgagaaaat gattggataa atgaaaaacc cccgcgggat gcgggggttc aatttaacga 3521881 aagaatccta aaacggtttg tagttttagg attctttcat cttttcagcg tgattgaaaa 3521941 cccttgaagt ctaggaagaa cgagcattgg agcgcagcga atgtttggaa ttcgtgagca 3522001 ccgaagcgca ggcctgacaa cgaatgcgag ggtttgtcga cacgctgaaa cccccgcggg 3522061 tgcgggggtt ttcttattac agcagcttct tccctaacag ggattctacg agctctactg 3522121 ctgttttgcc cgttttgttt ttgtgatcaa ggatcgggtt aacctcaacg aattcggctg 3522181 aggtaatgat gcctgcgtca tacagcattt ccatagccaa atggctctcc cggtagctga 3522241 tgccgccgac gacaggggtt ccgacacccg gtgcgtcgtt cggatcaagt ccgtccagat 3522301 caaggctcag atggacgcca tcacatgctg ataaataatc aagggtttct tcaatgacct 3522361 ttgtcatgcc aagacgatcg atttcgtgca ttgtgtacac cttcatgccg ctttccttaa 3522421 tgtacttgcg ctccccttca tcaagtgacc gggcgccaat gatgacgacg ttttccggtt 3522481 tgattttagg cgcgtagcct tcaaggttaa ccagtgactc gtggccaatg cctaggctga 3522541 ccgcgagcgg catgccgtga atattgcccg atggtgaagt ttcaagtgta ttcaaatcgc 3522601 cgtgcgcgtc ataccagatg acgccgagat tatcgtaatg cttcgctgtg cctgcaagcg 3522661 tgccgatcgc aatactgtgg tcaccgccca ggacaagcgg gaattttttc tcttcaatga 3522721 ctttgttgac cttttgcgcg agtttttcat ttcccgccaa aacggaattc aggtttttca 3522781 gttcctcgtc atttttgatt ttttcgcgat tgatcggaat gtcaccgaga tcttcaaccg 3522841 tataccccat gtctgacagc ctctcgatca gatgagcgta ccggatggca ctcgggccca 3522901 tatccactcc gcgtcgtgct tgtcctaaat ccattggcat tccaataacc gaaatcgttt 3522961 tatccatctg tgattccacc tcaacattta agataatgtc ctatgcgggt tataacaaag 3523021 atgacttgcg gacaacgttt ttaaagctct agctgacgat ttgcctgctg gcgtttttta 3523081 atgacgacat gataaatgat gtagcaaatg atcataaacg gtacgccgca atacagcgcg 3523141 atacgctgct ccggatcaaa tgcaagactg atgagcacga ccgtatttaa cgttaggccg 3523201 atcagcggaa gcaccgggta cagcggtgtt ttaaatttca aatcttctat cttcccgccc 3523261 tcacggatat atttgcgtct gaacatgatt tgggaaagcg agatcgtaat ccagccgacc 3523321 tgcgcgctca tgcccgccaa agataacagt accatatata cggtttcagc ctgcgcaaac 3523381 tttgtcagaa gtgataggca ggccacagcc atcgttacga ttaacgagta catcggtaca 3523441 ccgcgctgat ttgttttgcc aagcgctttg aaggcttgtc cttcattcgc catcgcgtac 3523501 agaatacgtg ttgatgcgta taaacctgag ttcgcaacag ataacagtgc gattaaaata 3523561 acaaagttca tgatatcagc tgcatatggg attccgattt gctcaaatac ggcaacaaat 3523621 ggactttcca cgacacccgc ctgtttccac ggaatcatgc cggcaatgac aatgattgaa 3523681 agcacaaaga acacaagcgt tctccatact gtctgtttga tggaccgcgg aatcgttttt 3523741 tcagggtctt cactttctcc ggctgcaacc ccgatcagct cagtcccctg aaacgcaaag 3523801 ttcacagtaa tcatcgtaat cagcattgcc tttatgccgt tcggaaataa cccgtcttca 3523861 taaaaatgtg tcaaaaacgg cgcctgctct ccgcccttca gatcaatcag gccaaacatg 3523921 gcagctccgc cgagaataat aaataaaagg ataatcaaaa ttttaatgcc tgagaaccag 3523981 aattcagatt ccgcaaaggc ttttgtggtg atcgcattta aaataaacat cagtgccgca 3524041 aagaccagac accagatcca cacgtctata tgcggaaacc agcgttgcat cagctgcccc 3524101 gctgataaaa attcaatggc gcatgtaacc gcccagccga gccagtacag ccagccgaac 3524161 gcaaacccga aggccgggct gataaatttc gtggcatagg tctggaagga ccccgacaca 3524221 ggaaaggcga ctgccagctc tcctaagcag agcatggtca aaaacatgat aaagccgccc 3524281 actaaatagg acagaaccgc gccgagcggt cccgcttggt taatggtaaa cccggttcca 3524341 aggaagaaac cggttccgat cactccgccc aatgaaatca tgaacaaatg gcgtgatttc 3524401 attgtccgct ggagctgatt tccgttatct tggtttgtat tcacattctg caccccttca 3524461 gcaacttgta ttggatctaa gctggaacat ctgcatggtg ctatcccagt ttgctgtcca 3524521 aagagtctct atctatttaa tataaaattc acttcttctc ataaagatac attatactaa 3524581 aatactgtag ctgagcaaat agggagtgct gatttttctg ttgtaaattt atacaaacga 3524641 agtgaatatc ccgccatggt gcggatttat gcgtttcgca gcacgtgctt aattttctct 3524701 atcgcccaat ccaagtcctc tttggaaatg attaatggcg gtgcaaaacg aatgactgta 3524761 tcatgcgttt ccttgcataa aagtccctct tccttcaaac gctcacaata cggacgtgcc 3524821 gcttcagtca attccacacc gataaacagc cctctgccgc ggacttcttt aatgacaggg 3524881 ctgtcaatac tctcaagctc gcttttaaag tattcaccaa gttcaagaga acgatccgcc 3524941 agcttttcat cctccagcac ttctaatgaa gcgatagaca ctgcacatgc aagcgggttt 3525001 ccaccaaatg ttgagccgtg tgagccaggg ttaaacacgc ctaggatctc gcggtccgcc 3525061 gcaatgcaag agatcgggaa cacaccgccg ccaagcgctt tgcccaagat atacatatcc 3525121 ggaacaatgc cgtcccagtc acaggcaaac gtcttgcctg tacgtccgag acccgtctga 3525181 atttcatccg caataaacaa gacattctct tccttacaaa tcgccgccgc ttcctgtaaa 3525241 aatccttcag gcggaatcac aatgcccgct tcgccttgaa tcggttcaaa caagaatgcc 3525301 gctgtattcg gcgtaatggc ctgtcgaagc gcttccacat cgccgtaagg aatgagtttg 3525361 attcctggaa gcatcgggcc gaatcctcgt ttatattcct cttcagaaga aagagatacc 3525421 gccagcatcg tgcggccgtg gaagttcccg acacatgcga taatttccgc ttgattgtca 3525481 gctacgccct tcacttcata cgcccagcgt ctcgccgctt tcaccgcgga ttcaaccgct 3525541 tcggctcctg tattcatcgg cagaatcatc tctttgcctg tcagtttagc tgttttttcg 3525601 taaaacggcc caagctgatc gttatgaaac gcgcgtgacg tgagggtgat tttatcagcc 3525661 tgatccttta atgcctgaat gattttcggg tgtctgtgcc cctggtttac cgcagagtaa 3525721 gcactcagca tatccatata ttcattgcct tccgggtcct ttacccaagc acccagcgct 3525781 tcagaaataa caatcgggag cgggtgataa ttgttggctc cgtaatgaga cgtctgatca 3525841 ataatttctt tggatttaga taaagctgtc atatttgaat tcccccttgt tttctgtttc 3525901 aacatgttat cctgctttcc ctttatataa atgcaagttc tgtgccaaat caagaattcg 3525961 tgtgttttct acaattttcg aggacaaggt gcaaaaacat tctgatattt cgagcgaaaa 3526021 tttcagcaag tgcaaaattc ttttgcatat cctctccgtt tttttataaa atagaagcaa 3526081 tattaagaaa ataattgagg gaggttcata cagtggtcaa agacagcgaa ttcctcacat 3526141 tggtttttca gagtatttta gatgaaatcg atgttggcct gcacgtggta gacgagcatg 3526201 gaaacacaat cgtttataac aataaaatga tgcagattga agatatggag aagcatgacg 3526261 tcttgaataa aaacctgatg gatgtgttta tgttttcaaa gcagcaggac agcacactgg 3526321 tacaggctct tcaggaaggc aagacgatta aaaacgtcaa acagagctat ttcaataata 3526381 aaggccagga aattacgacg atcaatcata catatcccat cgtccaagac ggcaaaatca 3526441 ggggcgccgt tgaaattgcc aaggatgtga caaagctgga acggctgatc agggagaata 3526501 tgaacaaaaa aggcagcaca acctatacgt ttgacagtat tctcggcacc agtccggcca 3526561 ttcaagacgt catcgaaaac gccaagcggg caacccgtac gtcatcatct gtccttctag 3526621 caggcgaaac cggcacggga aaagaactgt tcgcgcaaag tatccataat ggaagcgatc 3526681 gttctggcgg cccgtttatt tcgcaaaact gcgcggcact gccagacagc cttgtggaaa 3526741 gcattttgtt tgggacgaaa aaaggcgcgt ttaccggcgc tgtcgaccag cccggcctgt 3526801 ttgaacaagc ccacggcggc acactgctgt tagatgaaat caactcgctg aatctcagcc 3526861 ttcaggcgaa gctgctgcgc gcccttcaag aacggaaaat caggcgcatc ggttcaacaa 3526921 aggatacacc gattgacgta cgtattattg ccacgatgaa tgaagaccca attgatgcaa 3526981 ttgcaggcga acgaatgcgg aaggacttgt attacaggct gagtgtcgtc acactgatca 3527041 tcccgccgct tcgggaacga aaagaagaca ttttgcttct cgcgtcggag ttcatccaga 3527101 aaaacaacca tctgttccaa atgaatgttg aacacatcag cgatgacgtg aagcaatttt 3527161 tcctttctta tgactggccg ggaaatattc gcgagcttga gcatatgatc gaaggcgcaa 3527221 tgaatttcat gacggacgag caaacgatta cggcttccca tctgccctat caataccgca 3527281 tgaaaatcaa gccggctgac atcccagagc cggaaacacc aagacaccag ccagccgcgg 3527341 acttaaaaga aaaaatggaa agcttcgaaa aatatgtgat agagaacgtg ttaagaaaac 3527401 acggccataa catctcgaaa gctgctcagg agcttggcat cagcagacaa agcctccaat 3527461 atcggctgaa gaaattttct cactcgtcta acgaataatc cggagcagga agcctgatca 3527521 gaaaaacagt gcctctgccg atttcacttt tcacttcaat cgtcccattg tgattgtcga 3527581 taatcgattt cgttatggca aggcctaatc ccgaacctcc atatttccgg gagcgggatg 3527641 ggtctgcctt gtaaaaccgg tcaaacacta aaaaacgtca cttcttatgc attgaagaaa 3527701 gaaaatggca cctatgtgta tcacagccag caaccacacg gtacaaacca ttaaagtcca 3527761 tgcaaataac ggaagtattt gcagctaact gccatttgct gtttcacgtg taacatccat 3527821 cttgtatttt tcttcatatt cgatatatcc tttttcaact gaacgggcgt gacccctgtt 3527881 cagttttttt tgcatatcaa aacagcctgg caacgatgcc agactgcttt tattaactgc 3527941 ctaattggtc tgcggaggac agcttgatat caacagattt ttcttttccg ccgcgataaa 3528001 acttcacctt cacccggtca ccgacttttt tctgataaag ccgttttcgc aggtcaacaa 3528061 tatcatttac tttgtatccg tcaaattccg tgatgacatc cagttccttc agccccgctt 3528121 ttccggcagg tgaaaaggcg tctacaccca tcacaaccgc tccattggtg acgttcttag 3528181 gaagctttaa tgtttcatcc caatgatagc ttgcgatgtc acttagcgat ttcatctcaa 3528241 tgccaaggaa cgggcgtttg acctttccgt atctctctaa atcctctatc acagggatca 3528301 cgagcttaga cggaatggac aggccaatcc cttcaaccgc tgactcggca attttcattg 3528361 aattgatgcc aatgaccttc ccatccatat ttaacaaagc gccgccgctg ttcccagggt 3528421 taatggccgc atctgtttgc aggacttcag cgttccagtc aggctgtcca tcaccgtttg 3528481 aatctactgg gatcgccctc tccgtacccg agatgacgcc ttgtgtgaca gagcctgcaa 3528541 actcaaggcc taacgggttc ccgatcgcaa taaccggctc cccagacttc actttatctg 3528601 aatttccgaa atcagcgact gctttaatct tatcgctttt cacccgtaaa acggcaaggt 3528661 ccatcagctg gtcgctgccg acaagatcag ctgatacacg tgagccgtct ttcaagctga 3528721 tttcaatttg ggaagcgcct tcgatgacat gatggttggt cacgacataa gcggaatggt 3528781 catttttctt atagatgacg ccagagccgc tcccagcctc gccgctctct ccccaaatat 3528841 ctgatttttg gatgttcaca acaccgacaa cggcgggcga catattgctg acaatcttgg 3528901 tgacggcatt gttgacactg acattcaccg tcctgattga ttcccggcca ttgttgtttt 3528961 gctgctgatc taaggcgcct gtatccagcc cttcatttga aaggtacggc atgataaacg 3529021 ccattaatac ggcaccgaca atcacgccaa tcagactcga aagaaaatat ccttttttgc 3529081 ttctctttgg ctgttcagga gtagtatgtt cttcctcacg ttcgtaatcc accatattcc 3529141 atcctttcca agaacgttaa tatggttata ttgtgggtta gaaactccta gaatagtcat 3529201 gatttacata gaaaaattat acagcgcaaa gcggagtggc cttcttcgga tcggtgtcgt 3529261 ataagtcaaa tgtctcaccc gtcacaaatc ctttagaagc caatgtctgc tgcacagaca 3529321 ttcttgccag ctccttcatg ttgttgtcct ggctcaaatg cgccaggtaa atacgagacg 3529381 tctcatcgcc aatgacatcc gtcatcgcca aggcagcatc ttcatttgac acgtgcccga 3529441 cgtcacttaa aatccgccgc ttaatgctcc atgggtatct tcccatttgc agcataccga 3529501 catcgtgatt gctttcaaac acaaatacat tcgctgaacg gataatgcct ttcatccggt 3529561 cgctgacata tcccgtatct gtcattaacg cgagctttcg gccgctataa tggaatacat 3529621 aaaacatcgg ttccgccgca tcgtgggaaa cgccaaacga ttcaacatca agtccgccga 3529681 acgacttcac cgtctccatt ggaaatacaa acttttgatc ggtgtcaatt ttgccgattt 3529741 gattctccat cgctttccaa gtcttctcat tcgcatagat cggaagcttg tactttctgg 3529801 cgacgacacc aaggccctta atatggtcac tatgctcatg cgtcacaaaa atgccgtcta 3529861 catcatccag cttacgcccg atctgcgcca tcagcccatc catggctttt ccgctcaaac 3529921 cggcgtccac taaaaatgcg tgatcctctg tttcgaggta aaacgcattt cccgtactcc 3529981 cgctcgcaag tacgctaaat tgcaagctca tgtttgtctc actccattat tttcattgat 3530041 ctgtatctaa aatcgtactc tccaaagcat tcacagtaaa atactcttgt actgtctttt 3530101 tctcaccgtt cacttttttc tcgtactcga ccgtaattct ccataccggc gccagcacct 3530161 gcgtacttgt cagcggatat tgtgctacat agccgaattt acagctcttc acagtgctgt 3530221 attcttttaa ttgattttga tagtacaata gctcaaccgc atccatttca gtaattaagc 3530281 tttctttctg gatttgcttg aaggtctcaa gcgtagtctg gtcgtatgac acaacctcgt 3530341 ttttaccgtt taagtgcagc accacttgcc cgatcatatt agagggattg tcggtctttt 3530401 ggtaaatata atgaccttcg tacgtttgga agaaaataat ttctttcttc gatttatcaa 3530461 ccttccaaag cttatatttt tcgccatctt gaattttcga agaaacaagt gcctgagcat 3530521 cgtcctcgat atccttcttt gatagtgcga ttggatttgc aaacttcatt ttcaggctcg 3530581 ttactttatg atcatcacta ggcatgtcca tcaaaggctt ttgatccttc agcgcctcaa 3530641 tttcctcctt ggagaaagac ttttgatttg ccgtgatccg atagccttct gttgcttcct 3530701 tattcaagcc ttcatacgtg atatgatcgg ccttcatgtc atgctcgaca tcatttttaa 3530761 tgacttcata ttctttgccg gtagcctgcc atttttgaaa aaactgatag cctaagaaaa 3530821 tatctaaaat gaggaaggca acgatgaaga ttgattttgt cttattccac tccactgtta 3530881 gccccctcct tcctcaataa atcctttgta atcggcacaa tttttccatt tactttcatc 3530941 gcccaaaccg gttccagttc aacgagagga tcatcgttgg ttgatgttga taccaattga 3531001 taagcaagga agatctgatc aattttgtcc gtatcataag cggtttgttt cgaaagcagc 3531061 atcttcactt cgctgccgcc catgagctct gtttcacttg ttttaatcgg attcgttccg 3531121 agactgtaat tcggccgctt atagctgaga atatcatcat tcgcccattg caccgtaatc 3531181 gccgatgtcg ccccgaaagg tttggcggtg ctgttaatga ccgggatctg atccataaaa 3531241 atatagaagc tcaactgctg gctgtcattg atattgaaaa attgatagtg atccgtccag 3531301 cttccggtat cctcaaggta tttttggctc tttttgatta attcacctgt ttgataggat 3531361 gtgctctgca ccaaattgcg ctgctgaaat tgcacctgtc tctggcttag attcacatct 3531421 aaccggctga tcccatctgt cagcacattt ctgttggtgt aattcgaatc ttctcttaca 3531481 atgctcggat cactaaacaa agcctgctta aaggtatttg ttttaatcga ttctgtgaca 3531541 aattcttttt tgtccatcgt aagcggtttg ttcggcagca agaactcttt ctttgagcca 3531601 atggagaaca aactgaacgc cggcatattt gattgcctgt ttttcaagtc gttcataatg 3531661 ttccggtagt ttgctgattc aaccgtcact tcaagaatga gctgcttgct gtatgacacc 3531721 aaatagattt tcttgttcgc ttttgtttca ttgaacggga tcagaatatg gtcaaacgaa 3531781 ctgtattcaa acgactgatt agaccattta aacagcgttt ggaaaatatc aatcgggatc 3531841 gtatcgctga attgcaagtc aagcttggct tcagaaccgc ctattccata aaaccagctt 3531901 ttgaatccag ccttgtcata ctgatccgaa atatctttaa ttcctttcac atcccaatgc 3531961 ggcaagtcag accaaatttc ttcatagagg gcattgtcat ccactttgta atgagcgccg 3532021 tcatcatgga taaacatgtc ccttggcctt accgtttcag acagcttttg ggtggttttt 3532081 tcgattttat gtttcacacg aacagtagac tctgttgagg atgagccttc agaaaagttt 3532141 ggctggaacg tccatatccc ccatgtaaaa acaagactga tgacgacgag taccgtaagt 3532201 aatatcgttt ttatattttc acgcttcatc ccaatcatcc tcttgttcct ctttatatgg 3532261 aagagtaaat gtaatcgtcg tgccttttcc ttctatgctg tccgcccaaa tatctccacc 3532321 gtgcgcctgt accatttcct tggcaatcgc caatcccaga ccggtgccgc caagctttct 3532381 cgttctcgct ttatccaccc tgtagaagcg gtcaaagact ttttcgacat cttttttcgg 3532441 aatgccgatc ccttcatcct tcacgctgat atagagaagt tcttcctctt cattgacatc 3532501 aatcgagaac gtgacatgtc cgccttccgg tgaatatttt aaagcgttag aaataatatt 3532561 atcgagcacc tgcgttattt tatcctggtc aatctcgaca tacagatctc tgtccggcag 3532621 attgcggata aactccacat gctgctcttt tgtcatttca aaacggtcaa taataagtga 3532681 cataaaccgg acaatctgaa tccattcccg gttaaattga taatctttac tgtcaaattt 3532741 cgacagctga agcagatcat tgacaagccg gatcatacgc tctgtttcat tttgcgtcac 3532801 cattaagaag cgcggagcaa tgtctttatt ttcccacgcg ccttcagcta acgcttctaa 3532861 atagctgcgc attgtcgtaa gcggcgtccg cagctcatgt gatacattcg caacgaattc 3532921 tctgcgttcc tgatccattt tctcttgttc ggttacatcg taaatgacag cgattaaacc 3532981 atcaattttg ccgtgttccc tttgaatcac agagaaattc acgcgaagca ccgttaattc 3533041 atcatcgcgc tcaatttcaa gcagcataga atcctgctgt tccactaaat cttcaaaagt 3533101 ataattctct tgaagcccca gcaaactcgt aatcggcatt tctaaggctg tttcacgtga 3533161 aacgttcaac agttccagcg ccgggctgtt taagagaata atcgctccgt ttcggtttgt 3533221 ggcgataacg ccgtctgtca tataagcaat gacagaggct agctttctgc gttctccttc 3533281 agtcatcgcc tgggcatctt caagctctct cgttaagtgg ttaaacgttg tggccagctg 3533341 cccaatttca tcatgtccat actttttaac cttcctcgag aaattccctt tcgcaagctc 3533401 catcgcctgc tttcgcatat ctgaaagcgg gtgggtaatg gttcttgcca gaaaaatacc 3533461 gagaagagcc gtcaaaacaa gtgccaaacc tgtgccggac gccagtatcg tgttgatcgt 3533521 cttcatttga ttaaagacat cttccatact cgcgacaacg tagatcgcgc ccacaacctc 3533581 ttggttttca gtcatgacgg gcttcgcgga aataagaact ctgattttgc ttttcgggtc 3533641 ataatatttt cttaaatacg actgtttggt agaaaagatt cttttgaaaa tcagatcggt 3533701 cgtttgtttc ccagccactt cctcaccgta cggctttgaa gaaccgacca cttcatagct 3533761 tttatctaca aagctaattt cccgaacctc atcacttttc gtgaagtcat tcaaaatacg 3533821 gctgacgtca tcctttatga cggtactgtc gttatcgctc ttatattctt gttcgatata 3533881 ataagaaagg ttgtcgattc gctgattcag cgattgttca taagagctga tcagcgactt 3533941 ctctacctga ttgacaaaat acacaccaat gatttgcatg gcaatgataa tcaaaagcac 3534001 ataaatcaag gtaatcttaa attggatcga ccgaaaaaaa ccaaccttat tcatatgggc 3534061 attagtcctg ttctgggttt ctcaagtaat aacctacacc acggcgtgtg acgatccaat 3534121 ttggatggct cgggttgtcc tcgatttttt cacgaagccg gcggactgtt acgtcaaccg 3534181 ttctgacatc gccgaagtaa tcatagcccc aaacggtttg aagcaaatgt tcacgggtca 3534241 tcacttgtcc gatatgtttt gctaaataat gaagcaattc gaactcacga tgagtcaatt 3534301 cgattgtttc gtctcgtttt gatacaacgt acgcgtcagg gaagatgacg agagagccga 3534361 tatgaatctc gttagaggaa ggctcttcct ccgcaggcgc tgttgtcagc tggcggcgca 3534421 ggttcgcttt tacacgcgcc aagagctcgc gtgtgctgaa tggttttgtg acatagtcat 3534481 cagcaccgat ttcaagcccg ataaccttgt caatttctga atccttagcc gtcagcataa 3534541 tgattggcat atcgtatttc tttctgactt cgcggcatac ttcaacgccg tctttatttg 3534601 ggagcataat atctaaaaga attaaatcag gctgaagctc ttctaccatt tcaacggctt 3534661 cgtttccgtc gtgggcacag tgcacttcat agccttcttt tcttaagtta aattccaata 3534721 tatctgcaat cggtttttca tcatctacta caaggatctt tttatccatc attttgattt 3534781 tcctcctgcc gaatgacttc atttcatcta tataacattc gtttcatcac ttatggccca 3534841 tgtaaagaat gggtccttgt ctattataac ggtttaaggt caaaagataa aaaaaataaa 3534901 ggtttagaaa aaaaacacat gtttcacctt tatcgccagt tgtttatcta ttgtcatgct 3534961 ggtcaacttt ttttaaaaaa gataacttta ttgaaacctc ccctcaccgg agtgcgtctt 3535021 tatcaatgac gtcttcttct ttgaaccggc cgcagggccg gttctccctt tttcttctat 3535081 tataacactc ctcatgtttg cctttttcct aaaagaaaaa acgcacctac gattgcagat 3535141 gcgtttggta agtggctcgg gacggaatcg aaccgccgac acacggattt tcagtccgtt 3535201 gctctaccaa ctgagctacc gagccaaatg ttttattttt ctctactaag taaagtaaaa 3535261 tggcggtccg gacgggactc gaacccgcga cctcctgcgt gacaggcagg cattctaacc 3535321 aactgaacta ccggacctta cagtaattgc ccggagagct gtcgtgtcag ctctcacaga 3535381 caaataagga atttagcaat aacgctaaag taaatcaatg acccgtacgg gattcgaacc 3535441 cgtgttaccg ccgtgaaagg gcggtgtctt aaccgcttga ccaacgggcc ttcacgaaat 3535501 ggtgagccat gaaggactcg aaccttcgac cctctgatta aaagtcagat gctctaccaa 3535561 ctgagctaat ggctcttaaa gatgtcggaa tttctataga gcaaacgact taaatctagt 3535621 tctcatcttg tactctattg aagcagtttc cgtaacaacg agatttataa tatcacgaac 3535681 aaatagaagt ggcaataact tttttggttt tttttcatat ttttttctca gaccaactta 3535741 tatgcggctt tcaaacaaaa aacaagcccc ttaaataggg gcttgcagac atattctatt 3535801 tagttcgcac ggtacacact gcgaaggaca tttgtttgtg agcggtctgg accgacagag 3535861 aaaatagaaa gcggaatgcc tgtcagctga gacacacgct caagataatg gcgcgcattt 3535921 tccggaagct cgctcaagct cttcgcacct gtaatatcct cagtccagcc cggcatttct 3535981 tcatataccg gctcacattc agcaagtgcc ttaagacttg ctgggaattc ttcaatgatt 3536041 tcgcctttgt agcggtacgc cacacagatt ttcaacgttt caattcctgc taggacgtca 3536101 attgagttca gagaaagatc tgtaattccg ctcacacggc gggcgtggcg gacaacaacg 3536161 ctgtcaaacc agccgacacg gcgcgggcgg cctgttgttg ttccatattc gcgtccgact 3536221 tcacggattt gatcgccgat ttcatctttc agctcagtcg gaaaaggacc gtcgccgaca 3536281 cgagtcgtat atgcttttga tacaccgaca acgtgcttga ttttggtcgg gccgacacca 3536341 gaaccgatcg tgacaccgcc ggcaaccggg ttagatgacg taacaaacgg gtatgttcct 3536401 tggtcgatat cgagcataac cccttgtgcg ccttcaaata atacacggcg cccttcatca 3536461 agagcatcgt ttaagacaac agatgtatcg caaacatact ttttaatctg ctgtccgtac 3536521 tcataatatt cgtctaagat atcctcaagt ttaaaccctt ctgtctcgta cattttctcg 3536581 agaagacggt ttttttcttc aagattgcgc tcaagctttt ccgcaaacgc gtcacggtct 3536641 aacagatccg cgatgcgaat tccgatgcgg gctgctttat ccatgtaagc agggccgatt 3536701 ccttttttcg ttgtgccgat cttgttagcc cctttacgct cttcttccac ttcatccaat 3536761 ttcaaatgat acggcagaat gacgtgagct ctgttgctga ttctcaggtt atctgtactc 3536821 acgttgcgct catgaagata cgcaagctct gtgactaatg ctttcggatc tacaaccatt 3536881 ccgtttccga ttacacacgt tttatcctta tagaaaattc cagacgggat taagtgaagc 3536941 ttatatgtga ttccgtcaaa cttgattgta tgccctgcgt tatttccgcc ttgataacgg 3537001 gcgatcactt ctgcattttc tgataggaaa tctgtaattt taccttttcc ttcatcgccc 3537061 cattgcgtac ctactacaac tactgaagac atgtccgtgc acctccgtta acctttcaaa 3537121 acgattctat tcaaacaaat caagtttatc agtgaagaaa cagaaagtca attgtaaatc 3537181 cgaacattaa tttattgtaa atctatattc gttcgcttcc attcgtttta taagcgtttt 3537241 ctcactgctt tgtcataaaa agcttgcgaa actttcatcc tttagcataa gaaagaatca 3537301 cttgcctgat atcccttttg aattcataaa aacgatccgc cagccgtccg ggtcctctat 3537361 cgtcacgccc ccattgctcc agtacgggtt ctctgattcg acctcttgat agcccatgtg 3537421 ctttagcttt gaagtgatcg ctgccagttc aactgcattc ggcacataaa aaacaagaag 3537481 gctgtcggga tggggaacgg gggcagtgct tcccccttca tactgggtga attccaaatg 3537541 ataatcggca tgaggaaggc cgaacatgac accgtcatac ccgttatgct gtgaaaattc 3537601 tcctattcgt ttcaaacaca gtccctcttc gtaaaaacga ataatctcat caagctggcc 3537661 cgtaggacgc gcaattcgga tttgtgctgc ttgaaaagac gaaaaacgtt ttcccatatt 3537721 gttaccatct cctttttgca ccattttatt aaaacgcttt caatttttca tccgctgagc 3537781 gaacgtcatt tcttccatct ttcgaatgaa aaaaacccca agagcagctc ttggggctta 3537841 tgcgccgggc ggaacgcctg cgtcatcaaa acgccgttcc aggttgacga atttgttgta 3537901 ttcttttacg aacgcaagag acacggttcc taccgggccg ttacgctgtt tggcgataat 3537961 aatttcgata atatttttat tctcggtttc tttgtcatag tagtcatcac gataaaggaa 3538021 cgcgacaata tccgcgtcct gctcgatact tcctgattcc cggatatcag acatcatcgg 3538081 acgtttatcc tgacgctgct caacacccct ggaaagctga gaaagcgcga taacagggac 3538141 ttgcagctcc ctcgcaatcg acttcagttc acgggaaatt tcagatactt cctgctgacg 3538201 gttgtccttt gaacgaccgc ttccctgaat caattgcagg taatcgatca aaatcatgcc 3538261 cagcccgctt tcctgcttca agcggcggca cttggcacgg atttcactca ctcgaatacc 3538321 cggtgtatca tcgatgtaaa tcccgctgtt cgataggctt cccattgcca tcgtcagctt 3538381 gccccaatcc tcttcggtca ggttacctgt acggagattc tgggcattga tatttccctc 3538441 ggcacagagc atacgcataa cgagctgctc ggcacccatc tcaagactga aaatcgctac 3538501 gctctcatcg gtcttcgtcg ccacgttttg tgcgatgttc agggcaaagg ctgttttccc 3538561 tactgaagga cgggcagcca caatgatcaa gtcgttgcgc tggaaacccg cagtcatccg 3538621 gtcaagctcc gtaaaccctg ttggaattcc cgtgatatca ccttttcgat tgtgaagctg 3538681 ttcgatatta tcataggtct ggacaaggac gtccttaata ttttggaagg cactcgtgtt 3538741 tttgcgctgt gccacttcca taatcgtttt ttccgcttca ctgagtaaat cctcgacctc 3538801 atcctcacgg gtatacccgt cttgagcaat cgttgtcgca gttctgatta atcggcgaag 3538861 aatcgatttt tcctcaacga ttttcgcgta atattctatg ttagccgctg tcggcaccga 3538921 gtttgcgata tctgtcaaat atgaaatacc gcctacttct tccagcaggt ctgtgttcgc 3538981 aagctctgat gtaactgtca ccagatcaac cggttcacct cggtcaccga gcaccagcat 3539041 cgcattatag attttttggt gggacattct atagaaatca tctggaatca atacttctga 3539101 agccagtgtt aaagcagacg gctgtaaaaa aatagcgcct aacacggctt gttcggcttc 3539161 tatattttgc ggaggaagcc ggtcattcag aaggtctgtc atgctaagca ccgtcctctc 3539221 attaaaaaat ctccaacctc cattctacca tttctacaga aaaaaaatag aaaaattgtc 3539281 tgtttcctgt ttttttcagt tagcagattg gatcgtttcg gacagtaaca aggcgggaaa 3539341 aatgcaataa aacataaggg aggaatgaaa gatgataaag aaatatgcga ttacacctaa 3539401 tgttgatgcg gacggctggt ttattgaggt ggagaatgta gcgccgacag ctttgtatac 3539461 gtctaaagac gccgctattg aaaaggccaa acaggtggct aaggaaaaca gtccgtctaa 3539521 gcttgtaatt tatgaccagt ttaaaaatgt ggaagaagaa cactcatttt aatgaatgaa 3539581 agccttcgct gcagcgaggg ttttttagcg gttatcggtt tatttcatcc attggatgcc 3539641 tatgtgcatc atcaaatctg ccgctttttg atacagatcc cactccccga tcgaagcaaa 3539701 tttccccatc agctcctgaa gctttaacct cattgctata tattcttcga aagtgacagc 3539761 tttttcagtg tctatttggt gttccttcag catttgtttt aataaggata acggtgcgtg 3539821 cataagaacc ctccttacct cttttataac ggtcattttc cgattgctct attcctttgt 3539881 gacatcttct tacatttcac atctgattct tgtacaatgg acagaagaga ggagggatct 3539941 tttgtgagac ctttgcaaat ttctgccgaa actgcacaaa agcttgcaga gtccttgaat 3540001 ctgccgcttg aacagatcat gcatatgcct cagcatattc tgcttgccaa aatggctgaa 3540061 ctgcaaaaag aggacaaatc atagccttca ttcacatact tgcttacctg tttcgggata 3540121 atatcatgta tatgttagaa aagaggagta actgctttgc cacatccaca taataaaaaa 3540181 atccaatcat tttggctgat caccggcatt atctttatcg cctttaactt acggcccgcg 3540241 atcacttcag tcggtccggt catcagctct atccgggcag agctgcacat gtccaatggg 3540301 gcagccggtt ttttgaccgc actgccgctg ctttcgtttg cagttctttc tccgcttgca 3540361 cctaagcttg gacagcgcct cggtaatgag cgaactttat ggctaggtct cgtgatactg 3540421 ctgatcggtg ttctgactcg ttctaccggc tatactgccg ctttgttttt cggaacagca 3540481 cttatcggcg tcgggattgc gattggtaac gtacttttgc caagcttaat caaacataaa 3540541 taccctgaaa agccagggat catgatcagc ctgtatacga catcaatgaa tatattcgca 3540601 gctttagcat cgggtgtcag cgttccttta gcgacccaga tgaatggcgg atggaaacaa 3540661 gcctttctct tatggggcgg gctggcttta cttgcattgc taatctggat acctcagctg 3540721 cgccatcgag atacggcaaa ccagacaatg aagctgcaat ccagttccat ttgggcttcc 3540781 aaaatggcat ggtatgtcac catctttatg ggcctgcaat cgtttttatt ttacagcagc 3540841 atcgcttggt ttcctgaaat tctccgttca cacgggattg atacggcaac agccggatgg 3540901 atggtatcac tcatgcaatt tgcgagtctg ccttccactt ttctgacgcc agttttagct 3540961 gaccgtgtga aacagcagcg cggtatcgtt gcggcgctgg cctcagttta tctgatcggc 3541021 ctttgcggat tattagcggg cggaagccat acattgcttg ccatctggat gatcattatc 3541081 ggtatcggac aaggctccag cattagtctg gcccttactt tgattggtct ccgcagtgaa 3541141 aatgcccaac aggccgctgc gctgtcaggc atgtctcagt cattcggcta cctgctggca 3541201 gcagtcgggc caatctttgt cggctatctc tttgaccaga cgcattcttg gacgatgccg 3541261 attgtgcttc tcattgctgc cctgatcgta atgggagcag ccggacaggg agccggacga 3541321 gatcgataca ttttccagtc agaaaaacaa agaaattcag cataaagcgg ggaagatatc 3541381 tccgcttttt tctttgaata tttatggttt attcataagt ttttcatatt tgttttttac 3541441 aatgagacac cataaagagg tgaaaaacga tgaaaaccaa acgattcgac gcagccctta 3541501 ttcttatttt gctagcagca gcttttttga atacgtatca catttggcag gatgatacag 3541561 caaaccagta ctatttggcg gctgtaaaaa gcatgacgca aagcttccat aacttttttt 3541621 atgcgtcatt tgacccttct ggatttgtga cagtagataa gcctcctgtc gtgttatgga 3541681 ttcaaacgat tttcgcactg attttcggtg ttcacacgtg gagtgtcatc attccccagg 3541741 ctcttgccgg agttggatct gtcttccttc tctacagaat ggttaagccg acttttggag 3541801 ttggagcggc ccgcattgcc gcacttgtca tggcactgac ccctatcgca gtagctgtca 3541861 gccggacaaa caatatcgac agcatgcttg tttttacctt attgctcggt tcaacttgtc 3541921 tgcttagggc agtaaaacaa ggcaagctgg tttggctgct gacggcattt gccctgattg 3541981 ggctcgcctt taatatgaag atgatgcaag cgtttatggt attgcctgca tttgtgttat 3542041 tctacctgat tgcatctcgg gtttctctga agaaaaaaat cgggtccctg cttctgtctc 3542101 ttgtccttct gacaggcctt tcactctcat gggcgattgc agtggattca gcctcttcct 3542161 caagccggcc ttatgtagga agcagccaga ctaactcagt gctagaactg gcctttggct 3542221 acaacggcac agagcgtctg tttgggcaaa ctacgggcct tgcaaagggt gatatgaatg 3542281 ctgctggcgg agggaacatg cagaatcaag acaacatgca agcgccaaat ggcaacggtt 3542341 catctttttc tcagaacggt aatcaatcat tcggaaacca ttcacaggcg cctcagccgc 3542401 ctaacggaca aaccggcgct ctcaatggag gcggaggcac acctcccaca ggtggcaacg 3542461 gacctggaaa tggagggcct ggcggcggag gcggaaaaag cgtgaatatg ttcggcaccg 3542521 gtgatcctgg accgcttcgt ctcttccaat cagcactttc cggccaaatc agctggatgc 3542581 ttccattctc attgatcgga ttactgggcg caatcatcag ctggtaccgt gatcgccgcg 3542641 gacatgctgc taaaatgaaa gaaacgctat tctgggcggc ttggcttgtt cccgtggctg 3542701 gtttcttcag catcgcagga ttcttccacc agtattattt gattatgctg gcaccgccga 3542761 ttgccgccct ttctggtatc ggatggtata cgatgcaccg cttatacaaa aataataaag 3542821 actggtccag ctatcttctg ccggcagccg tcttgatcac agccgtgttt caggtgtata 3542881 ttctgagcgc ttatacaagc caaatcggca gtgtatggat gtatgtcctg gggctcttag 3542941 gactgggcat cacccttgca cttctgatgc ttaaacgcag ccatccgttc agtaagctgc 3543001 tgaccatcat cagcttgtgc gttctgcttc tcacaccagt ttactggtca gcaacgccgc 3543061 ttctatacgg tggcaacagc gtccttcctg aatccggccc gcagctcaaa ggctcagcaa 3543121 acggcgggaa catgttctct tcagaggtcg acagcgggct cctgtcctat ctgagaaaac 3543181 acaataccgg cgaagagtat ttatttgcta ctttgacaac cgtaacagct gcgccataca 3543241 tcatttacga aaatgaatct gttatggcaa tgggcgggtt taacggcacg gatcccattc 3543301 tgactgtgtc ggaactgaaa aaactgatca aagaaggcaa agtgaaatac ttccttctgt 3543361 cagaaaacaa ctcaggcaac agcgaacttg tttcctggat taagaaaaac ggaaaagaaa 3543421 taacatctga cgagtacagc ggttcctcca gcagcacaaa cagcgtgcag ggaatgcgaa 3543481 gaggacctgg cggagaaagc cagcaaactc tttatctcgt ggaataaaaa aagaggcttg 3543541 gatgaatcca agcctctttt ctattaagct tcttctttta catgtacctt taacacagcc 3543601 tgcacttcag gatgcagctt cacaggcacg tttgtatatc ctaatgcacg aatgccgtcc 3543661 ggcagttcaa gcttccgctt atctacttta atgttatggt ctttttggag ctgttcagtg 3543721 atttgcttgc ttgtcactga accaaataaa cggccgccct cacctgattt tgcgctaagc 3543781 tcaacagtca gtttttctaa tgtctctttc aagctcttag cctgctcaag ctcagcaatg 3543841 gcttcttttt tctctttctg cttttgtccg tttaacgcgc tgatgtttga cgcgttcgct 3543901 tcaaccgcga ggcctttttt aattagaaag ttatgcgcat aaccgtctgc tacgtttttg 3543961 acttcgcctt tttttccttt tccttttaca tcttgtaaga aaataacctt catctctgta 3544021 cgcctccctc aaaatactca tctatggcgt gcttcagccg ttccagcgct tcagaaactg 3544081 aaatgccgga caactgagtc gccgcatttg ttaaatgccc tccgccttcc agggcctcca 3544141 tgatgatctg aacatttacc tcgccaagcg accgagcact gatacaaacc gtttgttcat 3544201 cccgtctcgc caccgcaaat gaagcctcaa cctcactcat cgatagcagc gaatcggcag 3544261 cctgcgcaat cagcacttga tcgaagtatt cctcttcatt ttcaggaaga gaagcaatcg 3544321 caatgttatc tttatagagg accgtatgct ggatcagctt cgcccgttta atataggaat 3544381 caacggtttc tttcagaaac ttctgcacca gcaccgtgtc ggcgcctttt gcccttaaat 3544441 aagaagccgc atcgaaagtc cgcgagcccg tgcggagaga aaagctcttt gtatccacta 3544501 ttataccagc taatagggct gttgcttcaa tcatattgat ttttaagcgc ttcggctgat 3544561 attcaagcag ctctgtcacc aattccgctg tggaagaagc gtatggttcc atataaacga 3544621 gcagcggatc tctgataaac tcctcacctc ttcggtgatg gtcgatgacc acgatatgtt 3544681 caattttatt gaccagccgt tcctccatga cgagtgacgg cttatgtgta tcaacgatca 3544741 caagcagtgt gtcatcattg gaaatctcca ttgcttcttc aggcgtaata aatcttgacc 3544801 acagttcttc atattttttg atttccccaa tcaaacgctg cacacttgat ccgatttggt 3544861 ttgggtcaat cacgataaaa ccatctttgt tatttgcctg agccaccttt aaaatcccga 3544921 tcgctgcgcc gatagaatcc atgtcgggga atttatgccc catgataatc acattgctgc 3544981 tttcggtgac gatttccttt aaggcgtgag aaatcacgcg ggcccgcacc cttgttcgtt 3545041 tctccattgg gtttgtttta ccgccgtaaa acttcacctt gccgtttggc agcttaatgg 3545101 ctacctggtc tccgccgcgt cccagtgcta agtccaagct ggattgcgcc aaatcgccaa 3545161 gttctttcag ggaagagact gaagccccga caccgacgct taacgtcagc gctacaccgt 3545221 caaacgaggt tttttcccgc acttcatcaa gaatcgaaaa cttcgaattt tcgagttcag 3545281 ttaagatatg ttcattaagt acagcaataa agcgttctga agacgtcctt ttcaagaaga 3545341 tcccgtactc ctgcgcccaa gcgttcagca aagatgtcac ctggctgttc atcgtgcttc 3545401 tcgtctggtc atccaatcct tgtgtcacat catcatagtt atcaaggaaa atatatgcca 3545461 ggacggttct ttcgttttca tatagctttt caatctggat ttgttctgtt acatcaaaga 3545521 aatataagag acgctcatcc cgtttgatga caaccctaaa cttgcggtca ttcaatgtaa 3545581 ccgtttccga ttccacctct tgtttgataa gcggcactac cgattcacaa gtatcgtaaa 3545641 gtgatctccc cactaaagtg ctttcattaa aacaagagga aagaaacgga tttgcccatt 3545701 ctatataata ttggtcatta aaaagcatga ttccaatcgg catttccatc aatgcctctt 3545761 caccgacttt tttcaacctg taggacaacg tagaaatata agcatcaatc tcttgtcgaa 3545821 taagagaatc agcacgctta ataaaaaaca aaataactgc cagcagcagc acttcgacgg 3545881 ttcctaatat ccagttaaaa taaaagctga tgaggattgt aataattgac agagcaatca 3545941 atgcatagat gggataccga aacagcggtt tttcataaaa gcttggcatt tctatcactc 3546001 cccaccatgt gagtaaaact catgttcact tcaccttatt ccttatatga aagcccatat 3546061 ctaaaacgcc taaaatgcga atggccgcca tgaagaccgg atgcacaaac ccaagtatga 3546121 cagcaatcac agccgcagcc tttggatatt gtttcttatg gcaatagaaa aagataaatg 3546181 ataaaccttg gatgaaaatc agaaacccga gtataaactc cccatttaaa gcgatagagt 3546241 acagcatttg gcctttttct aaaggcaaaa atgaaagcat gacaataatc aaatacagta 3546301 ctacaacact ttgcggaaac ttcaactctc taaaaggctt tagattagga atatcggggg 3546361 agaatcgcct taagagcggc ttagcgataa ggtaactgag gaaagaaaaa ataactccta 3546421 ccatcacaat agctgttgga aaaagatatt gaacgatacc caattgttct tccatcagtt 3546481 ttaattgctt ctcaaactgc ccagcattgc ccgactgctt cgctacagtt tctacaatat 3546541 caagagattg ccggtattgt gtcattgcct catcaatgat attgataccc aaaaactgaa 3546601 tgcttatcac aaaatagaag acaatactaa gcatataaat aagagcgccc gaaataatgg 3546661 cgtgcccggg ctctttcctt ttgaaaaaat gtcccatggc aatgccggcg caagctgaca 3546721 taaaagctac aataagcccg ttaaaggacc cgacaataaa aacaaccgga agactgacag 3546781 cgcccatcca tatccctagc ttcaatccat gtctgatcgt atacaagatc attggcagcg 3546841 gcagtgcaaa taacagaatt gttccaatca caggaacata aacgaccaga agcgtaatga 3546901 tcgcaaacag actgattaaa atagcacctt ccattaaagc tctcgtttgt ttcacttagt 3546961 cacctcgtat catcctgaac atacgaatag aaaagagcag cataaacgac tgctcttttg 3547021 ttcatcgctg caacatgctt tgcaccgaat gtttttatat catctctaaa ttttactttt 3547081 atattttaac ataagtccaa atcgcaagta aaatgacgct aatgtttcat gtgaaacatg 3547141 aaaaaggaaa agacattctt tgaaaagaat gcccatcaca attaatgttt atcatccata 3547201 aagccagaag attccttgtt tttctttttc gtttttctga catacataaa aattaagatc 3547261 accagtaaaa gggttgttgc ttgcagaacg ccgctgctaa acaagaaaaa gttctttatc 3547321 atgtcccaca ttgtgtttca cctctttgtg catgttctca acccgtatcc tatataaggt 3547381 gaatttccct ttttaaaaac ttcaaaacat catgaacaac attgagcgtt gggcatatgc 3547441 tgatatggaa tctgatcgat aaaggagaat tttcacatgg atgaacgcag aacattggct 3547501 tggcatgaaa cattagaaat gcacgagctg gttgcttttc aatcaaacgg actcattaaa 3547561 ctgaagaaaa tgataagaga agtaaaagac cctcagctca gacagcttta taacgtgtct 3547621 attcagggtg ttgagcaaaa tttgagagag cttcttccgt tctttccaca ggctccgcac 3547681 agagaggatg aggaagaaga acgcgcagat aacccatttt acagcggtga cctgctcggt 3547741 tttgccaaaa catctgtccg cagctatgcc atcgcaatta cagaaacagc aacacctcaa 3547801 ttaagaaacg tactggtcaa acagctgaat gctgccatcc agctgcacgc ccaagtttat 3547861 cgatacatgt atcagcatgg atattatccg tcttacaacc tttctgaact gttgaaaaac 3547921 gatgtcagaa acgccaacag agccatttca atgaaataaa acaagcagca aaggagttcc 3547981 ctttgctgct atttctgctg atccttcact aagccgttcg aacgataaga ttccagcacg 3548041 tctctgttgg attctcccca ttctttcatt tgcaaaacaa tcggttcaag cgtgcgccca 3548101 aattccgtca gagagtactc taccttgggc ggcacctggt gataaacctc acggtgcacg 3548161 atgccgtccg cttccagctc cctcagctgg agagtaagca ttctttgagt aatactcggg 3548221 cagattcgcc gaaactcatt aaatcgtttc ttgccatcta tcatgtgata aaaaagaatt 3548281 cctttccact ttccgccaat gacatctaga gtgaattcaa ctggacagcc ttctttgttc 3548341 gggtatatat tctttttttc actcattctt gaccctccaa tagtaccttt tttgatacta 3548401 cattacattt tgcaactaat ctacccagta ttttacacac cttttctcct tagctcaaag 3548461 aaaatgcttc ttattcacat caatttttaa gggtttgcat gattacacct gcagcaagac 3548521 gtgttaaact atataaagat tacactactt aaaaaaggat aggagctatc atggaaaaga 3548581 tacttatttt cggacaccaa aacccagata cagatacgat ttgttctgcg attgcttatg 3548641 ctgatttgaa aaacaaactc ggcttcaatg ctgagcctgt ccgcctcgga caagtcaacg 3548701 gcgaaacaca atacgcgctt gactatttca aacaagaaag cccgcgtctt gttgaaacag 3548761 ctgcaaacga agtaaacggc gttatcctgg ttgaccataa cgaacgccag caaagcatca 3548821 aagacattga agaggttcag gttttagagg ttatcgacca tcaccgcatc gctaactttg 3548881 aaacagctga gccgctttac tatcgtgctg agcctgtagg ctgtacggct accatcttaa 3548941 acaaaatgta caaagagaat aacgtgaaaa tcgagaaaga aattgccggc cttatgctgt 3549001 ctgcgatcat ttctgattcc ctgttattta aatctccaac ttgcacggac caagacgtag 3549061 cagcagcaaa agagcttgcg gagatcgctg gagtagatgc tgaagaatac ggcttgaaca 3549121 tgttgaaagc aggcgctgat ctaagcaaaa aaacagtgga agagctcatt tctcttgatg 3549181 cgaaagaatt tacactcggc agcaagaaag tcgaaatcgc acaagtaaac acagtggaca 3549241 ttgaagatgt aaaaaaacgc caagctgaat tagaagctgt gatctcaaaa gttgtggctg 3549301 agaagaatct tgatctgttc cttctcgtta tcacagatat cttagaaaat gattcacttg 3549361 ctcttgcaat cggtaacgaa gcagcgaaag tggaaaaagc gttcaacgtt acattagaaa 3549421 acaacacagc cctcttaaaa ggcgttgttt cccgtaaaaa acaagtcgtt cctgtcttaa 3549481 cagacgcaat ggctgaataa gccattacaa ttgcttcaaa atccttgcgg ggtttccgcc 3549541 tacaacagta ttagcgggta catccttagt gacaacagat ccagaagcaa tcactgcgtt 3549601 atcaccgatt gtcactcccg ggttaatcac cgcccggcct ccaatccaaa cttgatctcc 3549661 aattgtcaca ggcttaccga actccttccc ggatttcctt tcgatcggat caagaggatg 3549721 accggccgtg tagatatgta cacctggcgc aatcaaacaa tgacagccga tacgcacctc 3549781 acacacatct aaaatgacac agtcaaaatt aacaaatgta tgatctccga tatgaatgtg 3549841 atagccataa tcacagcgga atgtcggcaa aatcgtgact tgatccccaa ccgaaccgag 3549901 cagctccttc aaaagcttcg tccgcactgc atcatcttcc ggtgtttcgt tgtattgtct 3549961 aatcagctgt ctcgcatgct tgcgttctag taatagttgt tgatcttccg aattgtataa 3550021 ttctccggct gccatttttt ctttttctgt cctcagcatt taagtcactc cagatgtcag 3550081 attgtaatct cgatcaaatt tccttcatca tcctcaatca cgctttcata gtagccgtct 3550141 cctgttgtcc tcgggccgtt tactactgcg aaaccatccg ccttcaatcg atcagtcagt 3550201 tcgtcaactt tctcccggct cccaacggaa aaggcaatat gtgcccagcc tgtcattgtt 3550261 tgtgagggcg gatcggtcac attccctttt ttcataattt ccagccttgc tccggaatca 3550321 aacgtaataa aataagactt aaaatctttt ttctcattat gatacaaatc attcgcttcg 3550381 ccattaaaat acgattcata aaaagacttc attcgctcta aatcattgac ccagaccgct 3550441 gtatgttcaa tctgcatttc ttcctcctcc ttcgccttca atgaagttat aaggtatgaa 3550501 atgcatttca gttcaagctt ttttcttaaa tttatgctga attttgatat cagcgggttc 3550561 atcctgcaaa aatagagaaa atgctgcgat gccgagctgc tcaagattca aatcaagcga 3550621 cggaaaacca agaacacggc tgatagaagt atttccctcg cctatgattt caacatccca 3550681 attattcttt ttggcaaata gatgaattcc agctgccact tcatcactat ttgcataaat 3550741 agcagtcgga acccgcccgc tcatataaaa atgttcagct gccagctcac catcattcat 3550801 atcgttgcat ccggacagca tatggcggtc ttccaacctt ccgcagacag ctttataggc 3550861 cgcagcttta tcagccgtgc tcgggctcct atcagcttct ctgacacacg taaaagcaat 3550921 attctcatgc ccgcggctct ttaaatagcg aaagctctct gcataagcag tttttctgtc 3550981 attaaaagca caagggacat caatgtctcc ggtatcctca caagcgatga ccggcccata 3551041 ttcctgataa gctaaaatgc tgtcccaatg attggcgcgg gaagtaatga tgagaccgtc 3551101 tattttcttc gttcttaaca gctctaaata tttgatttca atatcggggt tataattggt 3551161 ggggagaagg gtcgttgcat actcatgctg aaaagccgcc ttggtgattc cgttaacgat 3551221 tttatcaaag cagggatgat cgctataagg cagaatcaca ccgaccgtat gggttttccc 3551281 gcgaatgaga tcgattgcgg ttcgatttgg tgtataatcc aattccttca tgacttgatg 3551341 aacaagcttt ctcttttctt cagatacata cggatgatga ttcaatacac gcgagacagt 3551401 cgaaacagat acatttgcca gtcttgcgat ctcttttata tttgccatct ctttctcctt 3551461 ttcatataaa aaaagcagta agtgtaaaat ccttactgct atctcatcat atattgatga 3551521 taagttcaac aggacaatgg tcggaaccca tgacgtccgc tgatatgctg gcatcttcaa 3551581 tctgttcctt aaggctttca gaaacaacaa aataatcaat ccgccatcca atatttctgt 3551641 cccgggcgcc ggcacgatac gaccaccagg aataagcgcc ttcaagatca ggataaacat 3551701 gacgaaaaga atcaacaaag ccagcttcta agaaacgagt gaatgcctct ctttcttgat 3551761 ctgaaaatcc agcgttattc cggttcgcct ttggattttt caagtcaatc tcctgatggg 3551821 ctacattcaa atcaccgcat aaaatcactg gttttttctg atccaattca agaatataag 3551881 acagtaaagc ctcttcccat tgcatgcggt aatcaatccg ctctaatccc cttctggaat 3551941 tgggcgtgta aacagtcatc acaaacacgt tttcaaattc cagcgtaatc actctgcctt 3552001 cttggtcatg ctcttctact ccgataccgt agatgacctg cagcggttct tgcttagaaa 3552061 aaacagctgt gccggaatat ccttttttca ctgcataatt ccagtacaca tgatagtctt 3552121 caggctggag atcaacctgg ccgtcctgta tcttcgtttc ctgaagacat ataatatctg 3552181 catcctcttc tttcaaataa gagaggaaat ccatttttct catcacagcc cgcaggccgt 3552241 ttacattcca tgaaatcaac ttcatgtttc atcctccccc ctataaaaaa gagcaagaac 3552301 ccgaaggtcc ttgctcttta catatcagct tactcaccgc ttacgtatgg aagtaaagcc 3552361 atttgacgtg cgcgtttgat cgctgcagtc aatttacgtt ggtatttagc gtttgttcca 3552421 gttacacgac gtggtaaaat tttaccgcgc tcagaaacaa actttttaag aagatctaca 3552481 tctttgtagt cgatgtgcgt gataccgtta gaagtgaaat aacacacttt acggcgtttc 3552541 gcacgaccgc ctctgcgtcc tcctgccatt gtcatttccc tcctttcttt ttcattttag 3552601 gcgataatca cattagaatg gaagatcatc atccgagatg tcaatcggtt tgccgtcgtt 3552661 ggcaaatggg tcatcattaa agctgttccc ctgattgcgt ctctggttgt tttgatttcc 3552721 cccaaatgga ttatcatttt ggcctccgcc aaagtactgg cctccgccgc tgtttccttc 3552781 gttgtatcca cctgaaccag aaccgccgcc gtttttcggc tcaagaaatt gaacactttc 3552841 agcttggacc tctgtcacga agacacgctg tccttgctgg ttttcatagt ttcttgtttg 3552901 taaacggcca tctacgcctg caaggcttcc ttttttcaag aagtttgcaa cgttttcggc 3552961 ttgtcttctc caagtgacac aattaatgaa atcggcctca cgttctccgg actggttcgt 3553021 aaatgtacga ttcacagcaa gagtaaacgt agcaacagcc gcaccgtttg gcgtataacg 3553081 aagctctggg tcttttgtca gtcttccgac taatacaact cggttaagca taagaaagac 3553141 caccttttac cattatatat ttcaaaattg cttattcttc ttctttaaca acaatgtggc 3553201 gaatgatatc gtcactgatc ttagctagac ggtcaaattc ttgaactgcc gcagcgtcag 3553261 attgaacgtt tacgatttgg tagaaaccgt cgcggaaatc gttgatttcg taagcaagac 3553321 gacgtttacc ccaatccttt gttccagtga tctccgcacc gttagaagtc agaacgttgt 3553381 tgaaacgctc gataactgct tttttagact cttcgtcaat gtttgggcgg ataatgtaca 3553441 taacttcgta ctttctcatc tgtttgcacc tccttttgga ctaagcggcc cataatgggc 3553501 aaggagcaat aattctatta ctcacaattt tatattatac caaagctctt gtccctttac 3553561 aactgcatcc tatacattaa atcggaaatg aataacatct ccgtcttgga ccacatattc 3553621 tttcccttca aggcggactt ttcctgcctc tttagctcct gccataccgc cgcccgcaag 3553681 aagatcctca taagcaactg tctcagcacg aatgaagccc cgctcaaagt cactatgaat 3553741 aattcctgca cactcagggg ctttcatgcc ttttttgaat gtccaagctc tgacttcctg 3553801 ttctccggct gtgaaatatg ttgcgaggcc gagaagagag taagacgctt tgatcagctg 3553861 atcaagacct gattcttgaa tgcccagctc ttccaagaac atttgctttt cttcgccttc 3553921 aagctcagcg atttcagatt cgatttttgc acacacaacg ataacttctg cgttttcgcc 3553981 ggcagcgtac tcgcgaatct tcgctacatt ttcattgcca gatggatcag caacttcatc 3554041 ttcacttacg ttggccacgt acaaaatagg cttcgaagtc agtaaatgga gctgcttcac 3554101 aagcttttgc tgctcttcag tgaattctac agatcgagca ggcttttcac tctcaaacgc 3554161 ttctttcagt ttagataaaa tctcaaactc aaatacagcg tctttatctt tttgcttcgc 3554221 aagcttgctg acgcgtgtaa tccgcttttc aactgtttcc atatcagcga ggatcagctc 3554281 aaggttgatc gtttcaatgt catcaatcgg atcaaccttt ccggaaacgt gtgtaatgtt 3554341 gtcatcggaa aaagcacgga caacgtggca aatcgcgtca acttggcgaa tatgagatag 3554401 gaacttgttg ccgagtcctt ctcctttaga tgcgcccttt acaatccctg caatatcagt 3554461 gaattcaaaa gcagtcggca cagtcttctt cgggttgacc agctcagtca gcttttgcag 3554521 acgatcatcc ggcacctcta caattcccac gttcggatca attgtacaga acgggtagtt 3554581 ggctgattcg gcaccggcct gtgtaattgc gttaaatagt gttgattttc cgacgttcgg 3554641 caaaccaaca attccagctg ttaaagccat tctttcatct cctctatata aaaccgtcat 3554701 tgtatgaacg tattttgaac ctagagcaat tataaggagg ttcactggaa aagacaagct 3554761 gacaaaaaag cattttcagc ttgccaatcc ctttgattat gcttttttca agcctactaa 3554821 acagtcaaaa agcgtacttc ccattccatt atcagaattt gtatcatttg tcagtgcatt 3554881 gactgaccct ccaaaagccg cccacatgcc ttcatctata ttaatcgtct tcgcatgagc 3554941 ctgcttcatc actttcacct tgcccttcat gcttccgcgg tcattaaaga tgacaacttc 3555001 gtctccatcc tgaagatcct gcccagccgc tatatctgga gaaatatcga cctgaacgtg 3555061 ctgaagcttt tcaataaacg gcacatgctg tgaatgattg gaacgctgcg gatgaatgga 3555121 taagagcgta taagggtact ttccagctaa ctcctcatta tggaaaacag attcttcggg 3555181 cacatttaat tgaagcgagc cgctaaatcc tttttgctca gctagcgacg aagtaaattc 3555241 aaattttcca ctcggcgtca aaaactgata atcatcccac ggcacctgtt ttactggaag 3555301 agggaggtgg cctttttctt ttaaacgctc aagtgtcaca tcctctgctt ccaatgaaga 3555361 aagccccatc tctaaaaatt cttgagtgct gtattcaaac agctcgccaa acccaagacg 3555421 ttttgcaagc tctgaccaga tccagctgtc cgatttcgct tcaccctgcg gctccacaag 3555481 cttcttcccg tactgaacat aatgatgata catactggaa tagtagatat cttcttcttc 3555541 aaaaacagtg gcagtcggca aaacataatc acacagctct gcggtatccg tcataatgga 3555601 atcaatcgcg accgtcattg gaaccttttc aaatgcttgt ctcaccttat ttgtattcgg 3555661 cacctgagtc agcggatttc cgcacgtcac aataatcatc tcaatcgcag gatcagcagc 3555721 ggtcaacact tcttcagcct gtgtcatcat tgaaaaagaa cgggatgttg tttttaattc 3555781 cggcagcgtc agctttgttt ttgcaaagct ctcaccaatc tggacatttc cgaaattcgc 3555841 gccgccgccc ttaattccga catttccgct tgccgccaca agtgcatcaa tccaacgaat 3555901 cgttcccccg ccgtttttat atcgctgcat gccaagcccc ataaaagtag acaccggacc 3555961 atcagcatac aaacctgcca aatactccag ctcctccata gaagtttctg ttttcacaat 3556021 aaactcttcc agagaaacgg tcttcaaaag ctctttcaca tcatcaaaac cgacagaatg 3556081 ctcagaaata aacgtttcat ccgttcttcc catctcaatc agaaccttca aaacggctgc 3556141 cgcaagccag ccgtccattc caggctttac agagatatag cggtcggcaa gcttagcagt 3556201 cgggttgaag atcggatcaa tcaccgtaat cgtggcgccc ttctttttca cctgctgcaa 3556261 gtgatggtat aagtgcatat ttgttcttga tacatttctt ccccacacaa caacatgctt 3556321 gctgttgtaa atatcaagcg gtccgtgacc gtacgaacgg ccaaaatccc agctttgcgc 3556381 ctcgataccg gagccccagc atatgcttcc gacgatttcg gtcacgccgc catatccatt 3556441 aaaaaaacgc tgatcaagcg cttttaacag accgttattc gcataatcat ggctgtgcaa 3556501 aacagcagtc gtctccgacg tttccttgat ttcccgaagt ttatcggcaa tttcatcaag 3556561 tgcctgctcc caagaaatcc gcacaaactc gccattttgt tttttcattg gatagcgaag 3556621 ccgatcaggc gaatttgttt ttgtctcaag cattctgccg cggccgcaga ttttaccttc 3556681 cgtaatcgga tggtttggat ctccgtccac ttttgttacc tttccatcat caacagtcac 3556741 caaaaagccg cagctgtccc aacaattcag cggacatgcc gactgatgca ctttgctcat 3556801 cgccgtcttc tccttacctt ctatatgaaa aagcatgagt gtcggcctat ttatgaagta 3556861 ggctcctcat gcttgactag tacttttttt agttttcttt caaattctct tctcggaatc 3556921 ataacactgt gagagcatcc ctcacactta attcgaatat ccattcccat gcgtataatt 3556981 ttccagctgt tcgctccgca tggatgcggt tttttcattt ctacgatatc attcaggcca 3557041 aagtctttat ccgccaagac ccttcacctc ttttcctaaa ctgctgtatc tattgtacaa 3557101 aaaaactgat cataagagca atcaagatac ccgaaaagaa atacatcctc ttatttccat 3557161 ttactcaaaa taggatataa gagcagacaa actaacaaat acaaattgag catcccatat 3557221 atcggataca agaacgcgat caaatcagaa aatccgaaag aagtaaaagg taccattaac 3557281 actaacaaaa tcaacacaat catccatctc ggcatatgaa taaacgccat cagccggctg 3557341 gacaaaccca gcaaaccagc taccgtcgtc gtgtaaatcg ccaggcacag caccgccgtc 3557401 atacataaaa aaaggaaata aggcgcaccc tccagaacgg caaacagcgg tatttcaaac 3557461 tgagaaaggg agcccgccag ctccaccaac gtttcattat aaacaaatga gatcacgcca 3557521 aaaataagac cgcttgccac acttgcgatt tttgcttctc cgagcccttt catctctttc 3557581 ccaacagagg ataaaatcgc aacaactgaa aggatgttta aagaggtaaa cgtaatgctc 3557641 gcaggccagt tatactgctg ggacaaatca atcgtccacg tatggtgatg tgtgctctga 3557701 aaggagatca gcgcatataa aagccccgct actaacacag gaatcaaaat actatttata 3557761 gataatattc ctttcacatc ccacaaaaac aagcacactg tcacgatgca aatcagcgtg 3557821 attccccacc agaaaggaag cttgtacatt tgcagggtca caccgcctcc ggcaatcatc 3557881 accatagtcg tcgaaaacaa ataaaaaatg atgaggacat cataaatttt cgccagccat 3557941 ggccccatta aatgctccag aaccggcaga aaatgagtgg attgaacctt aaaactgatt 3558001 ttcatcacaa tataagacga gaaaatgaac ataattgtaa acagcacaat agcaagtccg 3558061 ctttccgccc caaaaaactg ccatatctcc tgaccgctcg catatccggc cccgatcagg 3558121 ctccctaata tgagcagcat ccacttcatt ccggctctcc acaacactat cacctcatag 3558181 acaaagttca gcttgttccc gttattgtta ctatataaat aaaggaaagc aaacatgcca 3558241 tattttcata gacatttgaa cacaagctga aattatcata cgaaatacac ataaaaaaga 3558301 ctgctaatac ggcagtctaa aaagagatat ttatttgttt gtccgcggaa tgaagaagtg 3558361 aacttcactc ttcacttttt tctaaccatt cctacctatt caagtgtttc ataagcagac 3558421 cattgcttga tcatgatcga ggcaatgggg gacaatactt gtaatcgccc actaaccatt 3558481 catatcatgc cctctacttt tttaaaatct ctggtgccat acacaaagca taaaaaatca 3558541 tactgctgga tatactgtaa acaaccttac ataactacac acaccatagc aattctgtta 3558601 cctactataa caaggaagtg aaacccatga atcgaaaagg cgggcttttt tcttctcagg 3558661 aacgagtaaa gcaatatgtt tcacatacag atgctgcagc ggcaaaacaa atccaaacca 3558721 tcctttcttc atccttacgt aaagctgctg gcaaaccaat tgtcgtggtt tgtatcggaa 3558781 cagaccgttc aaccggtgac tcattaggcc cgctcgtagg aatgaaactc aaacagatgc 3558841 agctcaccag attccatgtc tacggaacct tatctgaccc cgtccatgct gtgaacatga 3558901 aggataaaat caatgacatt cataaattac ataaaaaccc atttgttata gcagtcgatg 3558961 catgcttagg ccgcgttaag agtgtgggtt catttcaaat cggggacggg ccattaaagc 3559021 ccggagccgg tgtacaaaaa gaccttcctg aagtgggaga tcttcatatt aacggaatcg 3559081 tgaatgtgag cggttttatg gaatattttg tattgcaaaa tactagactc aacttggtca 3559141 tgaatatggc aaatgttcta gcggaaggtt tgagtttaac agatcggaca gagtggaggc 3559201 aagaacgcct taacccgttg caaaggctca ctgggcgcat ataaaataaa aaccatcttc 3559261 gtttgaaaga tggttttttc atttatgatt ctcgttcaga caaaagctct aaaatccggt 3559321 caaggtcttc attagagaaa aattcaattt cgattttgcc ttttttcttc tgtcttttaa 3559381 tattaactgt tgttccaaaa taattttgga gataggattc ccgttctttt agaaccgcat 3559441 ctttcacagg ttcttttttc tttgtttcac gtggaacatt ctgattcaac tgctgaatca 3559501 gctgctcaag ttggcgaaca ttgagctgct ccgcaatcac tttttgtacc agcggttcaa 3559561 gcttattttt gttttttaag ccaagaagcg tgcgtccatg tcccatagaa agcgtgcctt 3559621 cggcaataag ctgttgaata ttttctggca gtgtcagcag tcttaaatga ttcgcaatat 3559681 gcggtctgct tttcccaaga cgtttggcaa gctgctcttg tgtgagatct aagtgtttca 3559741 aaagggagtc atatgcctga gcctcttcaa gcggagataa atcttcacgc tgaaggtttt 3559801 ctaataaagc aatttccctc attaacgcct ctgataattc acggacaatg gccggaactg 3559861 tatctaaacc tgccagcttt gccgctcgaa aacgccgttc acccgcaaca atatcatagc 3559921 cttttaaaga ttttctgacg ataagcggct gaagaatgcc atgctgcagc acagattctt 3559981 ttagttcagc taatgcctcg tcatcaaagt gttttcttgg ctgataagga ttagggcgta 3560041 aatcggcaat tttaatttct tcaactgtct cttcagacaa atctacctga ttaaataacg 3560101 cattaatccc ttttccaagg cctttagcca ttcgcagcca cttcctttgc taaatctaaa 3560161 tatacttccg cacctcttga ccgcggatcg tataaaatga tgggttttcc gtgactcggt 3560221 gcctcactca gacggacatt acgcggaata actgtcttat atactttatc cctaaaatac 3560281 tttttaacct cttcaatcac ttgaatgcca aggtttgtcc gggcatcaag cattgtcagc 3560341 aatacacctt caatcattaa atcagtattc aaatgctttt gcacaagacg tactgtattt 3560401 aataactggc tgagaccctc caaggcataa tattcgcact gtacaggaat cacaacggaa 3560461 tccgaggcag taagggcatt aatcgtcagc aagcccaatg acggcggaca atcaatgata 3560521 atataatcat aattttgctt tactgcttca agcgctctct tcaatctcac ttctcttgat 3560581 attgtaggaa ccagctcgat ctcagcccct gcaagctgaa tcgtcgcagg aatcacatcc 3560641 aagttctcta ctgtcgttgc tttaataata tctattacat ctgcatcatc tactaaaata 3560701 tcgtacacac actgctctac atcggctttt tcaatcccta atccgcttgt cgcatttccc 3560761 tgcggatcaa tatctaccag cagaaccctt ttccctatgt aagccaaaca tgccccaagg 3560821 ttgacagacg tcgttgtttt gccgaccccg cctttttggt tcgtaattgc tatgattttt 3560881 cccacgatgt cacctacttt cacatgaaca tgtactatct tgcttctatt ctatcaaaaa 3560941 aagattaaag cgtttcattt ttttcatcat tttgttccga atcagaaggg aaataattga 3561001 aaattcaagc acgctttatg ctttctctta taaattctgc aatttctatg tttttttgac 3561061 ttaaaaaagg aatttcttaa agaaaaaaag aagaagtcac agtacagaac gtggaaacag 3561121 gatggtgaga aaatggttta tcaaacgaag agagatgtac ccgttacgct gatgattgtg 3561181 tttctcatat tactgataca agcagatgcc attgttcctt ttgtgctggg aaatatgaga 3561241 gtttccggct ggatcatttt tattctgctg actcttttaa atggactcat catttggagc 3561301 tttattgacc taaaatatgt attgaaggaa caccatctga tcattaaagc cggattgatc 3561361 aaacatcaaa ttccttatga aaacatcgat aaagtcgttc aaaaaaagaa actatggtcc 3561421 ggttttcgtc tgatcggctc tcgccatgcc atcacaatat attatcaggg gggatgggga 3561481 catgcagtaa tttcaccgca aaaatctgaa gaatttatcc acaagctcaa agaaaagaat 3561541 tctaatataa taatattcac taaaagtaag tgattacctt ttgttaaaaa tataaaaagc 3561601 tctcctgctt ttcaggagag cttctatttt ggtatgcgaa tcgttaattg aatatattct 3561661 tcaaattctt cttcttccgt attcaatttt acaccgctgt cttccaccat tgatagtgac 3561721 tggcgaatcg tgttcatcgc aattcttgta tctctgctga atgctttgcg tctcggcttt 3561781 ggctttctct ggccttgctc cagcattttc accacgcggt cttctgtctg ctttacattt 3561841 aaacttttct caataatctc tgtgagcagt gtgacttgga gctcaggctg tttcagcgga 3561901 atcagtgctc tggcatggcg ctcggtgatt ttcttctcca taatcgcctc ttggaccggc 3561961 tgaggcagct ttaataaccg aagcttattc gcgattgtag actgcccttt tcctaagcgc 3562021 tgtgcgagtg cctcctgtgt taaatcatgc agctcaagca gcctagcata agcatgcgct 3562081 tcctcaatag aagacagttc ttcccgctgc aagttttcga ttaacgccac agaagcggtt 3562141 tccgtgtcgg aaaaatcctt aataattgcc ggaatctttt cccactcaag cgattgcacc 3562201 gctctccagc gtctttcacc tgcaatgagt tcgtattggc cttcttcttc tgtatgccta 3562261 acaacaatcg gctgaataat gccgtgtgta tgaatggtca ttgctaactc tttgattttt 3562321 tcatctgaga aaatggtgcg tggctgaaaa cggttgggaa cgatagcatt taccggtatt 3562381 tccagaatct cttctttgtt tgtatcatgt tcagcaatct ccggctcctg ttccttctca 3562441 ccaagcccga agaaacgaga gaatgaatgc ttcatgtacc tacaccacct ttaaaaactg 3562501 ccatttttat aattctattt tctcatggtt tttcctgctg tacatccatc aattttgatg 3562561 aaaatatgat ggtattgtca tatcaggctg tctaaattac ccttcaattg gcgatttatt 3562621 aggagttccc ggttttcttg gatacttctt aggtgtattt tttattttgc gtatcaccat 3562681 aatattacga tcgctttctt caataggcag cttaaaagaa tggatattct caagttctcc 3562741 tccaagcgtc gtgattgctt ttttgcctgc attcagttct tcttcagctg atgcggcttt 3562801 taaagcaaca aataaaccgt ttttcttcac cagaggcaag caaagctcac tcaaaacaga 3562861 taatctcgca actgcgcgcg ccgtcacaat atcatagctt tcacgcacgt ctttccgttg 3562921 cccgaacgtt tcagctctgt catggcagaa tgttgtattc tccaattgca aagcttcaga 3562981 caacttttct aaaaacgtaa tccgtttgtt tagtgaatcc acgattgtga catggaggtg 3563041 cggaaagcat atttttatcg gcagacttgg aaaacccgct cccgctccaa catcacaaat 3563101 cgtgttcacc tgattgaagt cgacataaaa agcagctgta atggaatcat aaaaatgctt 3563161 taaatacact tcttttttct ctgttattga agtcagattg attttttcgt tccattcaac 3563221 cagcatgtcg taatacagct caaattgctc cagctgacgg ggagaaaggg agatcccttt 3563281 ttccgccaaa ccagaagtga attcttcaat attcatgccg tcatcctttc tactcggcta 3563341 tcttcgcaat gcgtccctgc tctaaataca ccaatagaat tgaaatgtcc gccgggttta 3563401 caccggaaat gcgggaagcc tgggcaacag acaaaggccg tacatttttc agtttttgac 3563461 gcgcctcggt cgcaatcccc ttaattgcgt cataatcaat tcggtctgga atttttttat 3563521 tttccatctt cttcagtttt tccacttgct gaagagattt ttcaatatat ccttcatatt 3563581 tcacttggat ttctacttgt tctgccacgt cttgaggaac cggcacttct ggcggcgcca 3563641 gttttgtgac tgtttcatag ttcatttcag gacgtttcat caagtctgtg ccgcgaactc 3563701 catctttcaa ttcgcttccg ccaagagaac ggatatattc ttgattttcc ggagacggct 3563761 tgataattac agaatgaaga cgttttttct ccgcctcgat cgccgctttt ttcttctcaa 3563821 aagccgcata gcgctcatca gaaatcaatc caatgcgatg tccgatttct gtcagacgca 3563881 aatcagcatt gtcatggcga agcagcaatc tgtattccgc acgtgatgtc aaaagacgat 3563941 atggctcatt ggtacctttt gtcacaaggt catcaatcag aacaccaata taggcgtcag 3564001 aacggcttag aattacttct tcttttccaa gcgcttttcg tcctgcattg attcccgcca 3564061 taatcccttg tcccgcagct tcttcataac cggatgttcc gttaatttgg cctgcagtat 3564121 aaaggtttgt gatttttttg gtttcaagtg tcggccatag ctgtgtcggt acgattgcat 3564181 catactcgat cgcatagccg gctctcatca tttgcacgtt ttcaagtcca ggaatcgttg 3564241 caagcattct ttgctgtacg tcttctggaa gacttgtaga taaaccttgg acatagactt 3564301 cctgtgtatt tctgccttcc ggctcaagga agatttggtg acgcggttta tcattaaaac 3564361 ggacaacttt gtcttcaatg gatgggcagt atcttgggcc cgtacctttg atcataccgg 3564421 aatacatcgg tgaacggtgc aggttgctgt caataatctc atgtgtctca gggcttgtat 3564481 atgtcagcca gcaagggagc tgatctgtga tatattccac tgtttcatat gagaaagcgc 3564541 gaggcacatc gtcaccaggc tgaatttccg ttttgctgta atcaatcgtg tcgcttttaa 3564601 cgcgaggcgg cgtacctgtt ttaaaacgaa caaggtcaaa accgagttcc tccaaatgct 3564661 cagaaagctt aatagaaggc tgctggttat tcgggccgct tgagtaagac agatcgccaa 3564721 gaatgatacg tcctcttaaa tatgtccctg tcgtcatgac aactgctttc gcacgataat 3564781 gtgcgcctgt ttgtgtaata acgcctcggc attcgccgtc ttcaacgatc agccgctcca 3564841 caattccttg cagcaatgtt aagtttggtt ctttttcaag cgtatttttc atttcgtgct 3564901 gatattggaa tttgtctgct tgcgcacgca atgcacgaac cgcaggacct tttcctgtat 3564961 tcagcattct catttgaata tgtgttttat cgatgtttct tcccatttct ccgccgagcg 3565021 cgtcaatttc gcggacgaca atcccttttg cggggccgcc gacagacgga ttacatggca 3565081 taaatgcaac catatctagg ttgatggtca agacaagcgt tttggcgcct tggcgtgcag 3565141 atgcgagggc agcctcaaca ccggcatgcc cggcgccaat cacaatcaca tcgtattggc 3565201 ctgcttcata ccccatgatt ctagttcctc ctttaattat tttcctaaac agaattgaga 3565261 aaagagctga tcaattaagc tttcgtggac agaatctcca atgatttccc ctaaaagctc 3565321 ccagcatctt gtaaggtcaa tttgcaccat gtcgatcggg acatcctgtt cgatgccgct 3565381 aagcgcatct tcaatggcgc gttttgcttg ctgtaaaata gtgatgtgac gtgtgttgct 3565441 gacataagtc agatcaccgc tttcaatggc acccgtgtag aacagtgatt gaatcgcttc 3565501 ttccagatca ttgatgcctt cctcttttaa aagagatgtc gtaacaactg gacgtccatt 3565561 ggcaagctca cggacacgtt cagtgtcaat cttcggctca aggtcagtct tattcaaaat 3565621 cacgataaca tccatgccct caacggcttc aaaaagcttc acgtcttctt cagaaagctc 3565681 ttcactataa ttaagcacaa gtaaaatcag gtccgcttcc tttaggacct ggcgagaacg 3565741 ttcaacaccg attcgctcaa caatatcctc tgtttcacga atacctgctg tatcaaccag 3565801 acgaagcgga acgcccctta cattcacgta ttcctcaatc acatcccgtg tcgttccggg 3565861 aatatcggtt acaatggctt ttgcctcatg aacgaggctg ttcagaagag atgattttcc 3565921 tacgtttggc cggccgataa tgacggtaga aagaccttca cgcaagattt ttccttgctc 3565981 agaagtcctc agcagcgtct caatttcctt tttcacggcg gttgcctttt cgactaaaat 3566041 ctgatgcgtc atttcctcta catcatcata ctccggataa tcaatattca cctcaacatg 3566101 ggccagtgtt tctaaaatct cactgcgcaa acggcgcacc aaagcagaaa gacgcccttc 3566161 catttgattc atagcaacgt tcattgcccg gtccgttttc gctctgatta agtccataac 3566221 cgcttccgcc tgtgaaagat cgattcggcc gtttaaaaac gcacgtttcg taaattcacc 3566281 aggctctgcc agtctcgctc cctctctcaa tgcaagctga agcacttggt tcacagtcac 3566341 aattcccccg tgacagttaa tctcgatgac atcttctcgt gtaaaagttc tcggcgcttt 3566401 taacactgat accattactt cctcaacgac acgatccgaa ggtctgtcta cgatatgacc 3566461 ataatgaatc gtatgtgatt cgaccgagct gagtgttttc cccttcggtc ccttataaat 3566521 tttatctgcg atttgaatgg cttctggtcc gctcaaccgt acaatcgcaa tcgcgccttc 3566581 tcccatcggt gtggaaattg ccgcaattgt atccatgttg ttcacctctc tttacttata 3566641 cttcatctat ataaaaaaat ttttattatg ccaaaactaa aagataacat agtttggttc 3566701 gaagtggaag atttgttatc cacagaaata gaaattcgtc ccttattact ttaacttatc 3566761 cacatgtgaa taacaattaa ttttatttcc tgaacttcct ttttatcaac aggatacacc 3566821 taaaaagaaa aaacttaaac ggcaaaacct tgatattact aggaaaagta gatttttcgg 3566881 atacaaaaaa accgaaatcc aatttttatc ggacttcggt tttatgctat cttttatggg 3566941 aaataacgag atgacgattt tcgccttcac ccattgaata tgttttgatc tggtggtttg 3567001 catatccaga aagagtatcg tgaataattt ttctttcgct ggacggcatg ggctcaagct 3567061 ggatggattt tttcgttttc aaaacctggt cagcaagctt gatggccagc tggctcagtg 3567121 tttcttttct tttcaaacga tagttttctg catccaccgt cacattttta tattggcctg 3567181 gataacggtt aagggcaagc tgtgtcaaag tttcaagggc gtttaaagtt tgtcctcttt 3567241 tcccaatcaa caatgctgcc ttttcacctg ttatatgata tctcactgtc tttttgcttt 3567301 cttgaacagt cacatcagac ttcccggcaa tggcttcggc aatcgtttga agatataact 3567361 tcgcttgctg aatcggatca atcttttcaa ccagctttac gatcgcaggc tttttaccga 3567421 aaataccgag aaaccctttg tttccctctt caataacagt aatttctacc ttatccttcg 3567481 ttaatcccaa ctcttgcaat ccggactgta ctgcttcatc gacatttcgc cctgcagcag 3567541 tcacattcct cactttttct ttcctccggc tttttgcggc tcaggatttt ttttaatatc 3567601 aggtccttta atgaggaaag tttgcgcaat cataaacaag ttaccaacta cccaataaag 3567661 agaaagagcc gccgggaagt tgatcgcaaa tacgataatc ataattggca taatccaaag 3567721 catcatcgcc atttgcggat tttgctgcgc attgccagcc atcatcagtt tttgctgaac 3567781 aaatgtagcg acaccggcaa cgataggaag aatatagtaa ggatcttttt ctcctaagtc 3567841 aaaccataag aagctatgct ctgaaatcgc ctgggttctc atgatcgcat gatagaatcc 3567901 aattaaaatc ggcatctgga tcaaaatcgg gaaacatccc gccaatggat tgacaccatg 3567961 cttttggaat aaagccattg tttcctgttg aagcttttgc tgcgtttttt gatcctttga 3568021 gctgtatttt tctttaagct tttgcatttc cggctgtaaa gcctgcatcg ctttcgaact 3568081 tctcagctgc ttaatcatca gcggtaaaat taataaacga attaaaatgg taactagaat 3568141 aattgaaagc ccgtagttat ctcccgtcaa tttcgctaca tacgtaatga gctcagacaa 3568201 tggatatact acgtacttgt cccagaaatg cggactatct gcagtgatcg gctctttcac 3568261 actcgagcat ccagccaaaa gcatgaatac gccaaccata cttaatagca accctattct 3568321 ccttttcaac aacatttcct cctataatta atctttacac tcttttattg caaagcatac 3568381 ttgtatgtat tttagcatct ttcagtttta aatggtgtct ttttctgatc aaccagaaag 3568441 gaagcgcttt taaaagttgt aagaaagcag tggtgatgcc tactttgacg aagatttctt 3568501 atataatgaa gactttctga atagatgctg cagacttttt ttcgtttcct catatgtcag 3568561 ctggctcgcc ggttttctgg caataatgat gtaatccttt tccttcagtc tctctttctc 3568621 ttcaagaaag gcctgccgaa tcaaacgttt gatccgattt cgcatcacag cattgccaat 3568681 ttttttgctg acggaaagcc cgacacgcag ttcatcattt tcaggctgat caagcgtata 3568741 taagacaaac tggcggtttg caactgatgt cccatgttta aacacttttt gaaaatcttc 3568801 atttttcttt aaacgatttc gcttcttcaa atgactcact ccgatactgg ctggcagaaa 3568861 cttttaaaat ttattatgaa catgagatgc atctgaacca ggaagcatgc cccggttcat 3568921 tacgcatcac atctatcttt tcccataacg tgaaaaaaga ccactgacat tattcagtgg 3568981 cctaagctga taatactttt ctgcctttgc ggcgacggcg tgctaaaact agacgaccgt 3569041 tttttgaact catacggctt ctgaagccat gaactttgct gcgtttacgg ttattcggtt 3569101 ggaatgttct tttcatttat gacacctccc tcgaggaata gctgttaaag acagtcttac 3569161 ttattatatt tgcgttacct attcattgtc aacttcacta gtgcttttat ttcttgcaac 3569221 cataatagga taccatacct tttcaacttt cgaaacctta ttttttagat tccttaattt 3569281 tacggaaaaa agacaaattc aaacaatttg cccctaaaat cacgcatgtg gatatctttt 3569341 tcggcttttt ttagtatcca cagaggttat cgacaacatt ttcacattac caacccctgt 3569401 ggacaaggtt ttttcaacag gttgtccgct ttgtggataa gattgtgaca accattgcaa 3569461 gctctcgttt attttggtat tatatttgtg ttttaactct tgattactaa tcctaccttt 3569521 cctctttatc cacaaagtgt ggataagttg tggattgatt tcacacagct tgtgtagaag 3569581 gttgtccaca agttgtgaaa tttgtcgaaa agctatttat ctactatatt atatgttttc 3569641 aacatttaat gtgtacgaat ggtaagcgcc atttgctctt tttttgtgtt ctataacaga 3569701 gaaagacgcc attttctaag aaaaggaggg acgtgccgga ag //